Patent Publication Number: US-2022218001-A1

Title: Redox enzymes in animal feed compositions

Description:
This application contains a Sequence Listing in computer readable form, which is incorporated herein by reference. 
     FIELD OF THE INVENTION 
     The present invention also relates to new polypeptides of fungal origin having superoxide dismutase activity and to animal feed additive or animal feed comprising superoxide dismutase of fungal origin. The present invention relates to the use of polypeptides of fungal origin having superoxide dismutase activity for
         improving one or more performance parameters, wherein the one or more performance parameters is selected from the group consisting of the European Production Efficiency Factor (EPEF), Feed Conversion Ratio (FCR), Growth Rate (GR), Body Weight Gain (WG), Mortality Rate (MR) and Flock Uniformity (FU),   improving or enhancing immune response and/or reducing inflammation and/or for the modulation of the gut flora in an animal, and   reducing or eliminating the use of antibiotics administered to animal feed.       

     BACKGROUND OF THE INVENTION 
     Superoxide dismutase (SOD, EC 1.15.1.1) is an enzyme that alternately catalyzes the dismutation (or partitioning) of the superoxide (O 2   − ) radical into either ordinary molecular oxygen (O 2 ) or hydrogen peroxide (H 2 O 2 ). Superoxide is produced as a by-product of oxygen metabolism and, if not regulated, causes many types of cell damage. Thus, SOD is an important antioxidant defense in nearly all living cells exposed to oxygen. SODs are used in the pharmaceutical, cosmetic, food, and environmental protection industries due to their excellent antioxidant properties. Historically, SODs were isolated from animal or plant sources, but the microbial sources organisms can be easily induced and cultivated on a large scale 
     SODs naturally occur in many organisms such as plants, insects, birds, reptiles and mammals. Four types of SODs have been reported according to their metal cofactors: manganese SOD (Mn-SOD), iron SOD (Fe-SOD), copper/zinc SOD (Cu/Zn-SOD), and nickel SOD (Ni-SOD) 2 . 
     Commercially available mammalian (bovine) SOD (Sigma), a Cu/Zn SOD, although having a high activity at neutral pH or at its optimal pH of 7.8, was found to lose 65% of its activity under gastric stability studies. According to its datasheet, its pH range is 7.6-10.5. Commerically available bacterial (from  E. coli ) Mn-SOD (S5639 from Sigma) was found to lose 57% of its activity under gastric stability studies. 
     Surprisingly, the inventors of the present invention found that fungal SODs are gastric stable and provide beneficial effects when used in an animal feed or animal feed additive, alone or in combination with a catalase, to improve one or more performance parameters, enhance immune response and reduce inflammation in an animal and thus lead to many advantages such as improving animal health and/or animal performance, and/or reducing feeding cost. 
     SUMMARY OF THE INVENTION 
     The invention is directed, at least in part, to novel polypeptides of fungal origin having superoxide dismutase activity and directed to an animal feed additive comprising a polypeptide of fungal origin having superoxide dismutase activity. A further aspect is directed to an animal feed additive comprising at least one and no more than two enzyme classes, wherein the at least one enzyme class is a superoxide dismutase of fungal origin and the optional second enzyme class is a catalase. 
     The novel polypeptides are isolated fungal polypeptides having superoxide dismutase activity are selected from the group consisting of:
         a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 1;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 2;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 3;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 4;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 9;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 10;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 11;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 12;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 13;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 14;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 15;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 16;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 17;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 19;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 20;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 21;   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 22;   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 23;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 24;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 25;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 26;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 27;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 28;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 29;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 30;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 31;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 32;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 33;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 34;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 36;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 38;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 39;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 42;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 43;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 44;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 45;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 46;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 47; and   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 48;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:199;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:200;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 201;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:202;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:203;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:204;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 205;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:206;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:207;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:208;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:209;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:232;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:233;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:234;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:235;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:236; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:237.       

     Alternatively defined, the novel polypeptides having superoxide dismutase activity are isolated fungal polypeptides selected from the group consisting of:
         a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 83;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 84;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 85;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 86;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 49;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 50;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 51;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 52;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 53;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 54;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 55;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 56;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 18;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 57;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 58;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 59,   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 60,   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 61;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 62;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 63;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 64;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 65;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 66;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 67;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 68;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 69;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 70;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 71;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 35;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 37;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 72;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 73;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 74;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 75;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 76;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 77;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 78;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 79;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 80;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 81;   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 82;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 210;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 211;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 212;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 213;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 214;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 215;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 216;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 217;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 218;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 219;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 220;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 238;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 239;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 240;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 241;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 242; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 243.       

     The animal feed additive comprising one or more polypeptides of fungal origin having superoxide dismutase (SOD) activity wherein the polypeptide having superoxide dismutase activity is selected from the group consisting of
         a. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 5;   b. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 87;   c. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 88;   d. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 89;   e. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 90;   f. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 91;   g. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 92;   h. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 93;   i. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 94;   j. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 95;   k. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 96;   l. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 97;   m. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 98;   n. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 99;   o. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 100;   p. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 101;   q. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 102;   r. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 127;   s. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 128;   t. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 129;   u. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 130;   v. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 131;   w. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 132;   x. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 133;   y. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 134;   z. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 135;   aa. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 136;   bb. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 137;   cc. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 138;   dd. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 139;   ee. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 140;   ff. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 141;   gg. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 142;   hh. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 143;   ii. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 144;   jj. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 145;   kk. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 146;   ll. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 147;   mm. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 148;   nn. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 149;   oo. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 150;   pp. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 221;   qq. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 222;   rr. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 223;   ss. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 224;   tt. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 225;   uu. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 226;   vv. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 227;   ww. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of 228;   xx. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 229;   yy. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 230;   zz. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 231;   aaa. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 244;   bbb. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO SEQ ID NO 245;   ccc. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 246;   ddd. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 247;   eee. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 248; and   fff. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 249.       

     The invention is furthermore directed to an animal feed or animal feed additive comprising polypeptides of fungal origin having superoxide dismutase activity. The present invention relates to the use of polypeptides of fungal orgin having superoxide dismutase activity for the maintenance of general health or intestinal health or the prophylactic or preventative treatment or early treatment of symptoms associated to direct and indirect environmental stresses. Direct stresses result from for example temperature, solar radiation, humidity, rainfall and wind velocity. Indirect stresses comprise those which affect the supply and availability of food (nutritional stress) and are determined by climatic and other factors which affect the growth of the plants that animals eat. 
     The present invention relates to an animal feed or animal feed additive comprising one or more polypeptides having SOD activity, typically to an animal feed additive comprising a superoxide dismutase of fungal origin and optionally of a catalase. 
     Alternatively defined, the present invention relates to an animal feed additive comprising at least one and no more than two enzyme classes, wherein the at least one enzyme class is a superoxide dismutase of fungal origin and the optional second enzyme class is a catalase. An aspect of the invention is directed to an animal feed additive comprising an enzyme component, wherein the enzyme component comprises all of the enzymes of the additive and consists of a superoxide dismutase of fungal origin and optionally of a catalase. The animal feed additive as defined above suitably may further comprise of one or more polypeptides having catalase activity and/or one or more vitamins. A further aspect of the invention is directed to the use of an animal feed additive as defined herein for replacing or partially replacing antibiotics in animal feed. 
     The invention also relates to a method of
         improving one or more performance parameters in an animal comprising administering to the animal an animal feed or animal feed additive comprising one or more polypeptides having superoxide dismutase activity, wherein the one or more performance parameters is selected from the group consisting of the European Production Efficiency Factor (EPEF), Feed Conversion Ratio (FCR), Growth Rate (GR), Body Weight Gain (WG), Mortality Rate (MR) and Flock Uniformity (FU).   improving or enhancing immune response and/or reducing inflammation and/or for the modulation of the gut flora in an animal comprising administering to the animal an animal feed or animal feed additive comprising one or more polypeptides having superoxide dismutase activity.   reducing or eliminating the use of antibiotics administered to animal feed, comprising administering to the animal an animal feed or animal feed additive comprising of one or more polypeptides having superoxide dismutase activity.       

     An aspect of the invention is directed to a method of improving or enhancing immune response and/or reducing inflammation and/or for the modulation of the gut flora in an animal comprising administering to the animal the animal feed additive as defined herein or an animal feed comprising the animal feed additive as defined herein. 
     An aspect of the invention is directed to a method of reducing or eliminating the use of antibiotics administered to an animal feed, comprising administering to the animal the animal feed additive as defined herein or an animal feed comprising the animal feed additive as defined herein. 
     A further aspect of the invention is directed to the prophylactic care or management, reduction or prevention of oxidative stress in a monogastric animal comprising administrating to said animal superoxide dismutase and optionally catalase. Oxidative stress is a disturbance between antioxidant/oxidant status in favor of excessive generation, or slower removal of free radicals, such as reactive oxygen species (ROS). Excessive ROS content leads to damage of proteins, lipids and nucleic acids, with consequent loss of their biological functions and subsequent tissue injury. Oxidative stress has been linked to initiation and progression of several infectious diseases. Accordingly, a further aspect of the invention is the prophylactic care or management of infectious diseases in monogastric animal comprising administrating to said animal superoxide dismutase and optionally catalase. A related aspect is directed to a use of an animal feed additive as defined herein as an antioxidant, preferably in animal feed and feed premixes. 
     The administration is suitably by means of feeding said animal a feed additive or feed comprising an enzyme component, wherein the enzyme component comprises all of the enzymes of the additive and consists of a superoxide dismutase and optionally of a catalase. 
     The invention is further directed to an animal feed comprising one or more protein sources and one or more energy sources characterised in that the animal feed further comprises one or more polypeptides having catalase activity and/or one or more polypeptides having superoxide dismutase (SOD) activity, wherein the animal feed
         a. reduces FCR by between 1 to 10%; or   b. increases average daily WG by between 1 to 10%; or   c. increases average daily feed intake by between 1 to 10%; or   d. any combinations of a.-c.;       

     when fed to the animal as compared to animals fed a feed composition without the polypeptides. 
     The invention is further directed to an animal feed comprising one or more protein sources and one or more energy sources characterised in that the animal feed further comprises one or more polypeptides having superoxide dismutase (SOD) activity, wherein the animal feed
         a. improves or enhances immune response; or   b. reduces inflammation;       

     when fed to the animal as compared to animals fed a feed composition without the polypeptides; and 
     said feed optionally further comprising one or more polypeptides having catalase activity. 
     Alternatively stated, the invention is, in a further aspect, directed to an animal feed comprising one or more protein sources and one or more energy sources characterised in that the animal feed further comprises one or more polypeptides having catalase activity and/or one or more polypeptides having superoxide dismutase (SOD) activity, wherein the animal feed
         a. improves or enhances immune response; or   b. reduces inflammation;       

     when fed to the animal as compared to animals fed a feed composition without the polypeptides. 
    
    
     
       BRIEF DESCRIPTION OF THE FIGURES 
         FIG. 1 : illustrates the body weight gain (BWG) in poultry from days 0-35. The graphs illustrate the negative impact of heat stress on BWG. In the non-heat stressed animals, the effect of the SOD/CAT combination outperformed or equaled the positive control (Vit E/Se). In heat stressed animals, both the Vit E/Se positive control and the SOD/CAT combination improved BWG. 
         FIG. 2 : illustrates the Conversion Ratio (FCR) in poultry from days 0-35. The graphs illustrate the negative impact (increase) of heat stress on Feed Conversion Ratio (FCR). In the non-heat stressed animals, the effect of the SOD/CAT combination equaled the positive control (Vit E/Se). 
         FIG. 3 : illustrates the Mortality in poultry from days 0-35. The graphs illustrate the negative impact (increase) of heat stress on Mortality. In heat stressed animals, both the Vit E/Se positive control and the SOD/CAT combination reduced Mortality. 
         FIG. 4 : illustrates the body weight gain (BWG) from days 27-35. The graphs illustrate the negative impact of heat stress on BWG. In the non-heat stressed animals, the effect of the SOD/CAT combination outperformed or equaled the positive control (Vit E/Se). 
         FIG. 5 : illustrates the Conversion Ratio (FCR) from days 27-35. The graphs illustrate the negative impact (increase) of heat stress on Feed Conversion Ratio (FCR). In the non-heat stressed animals, the effect of the SOD/CAT combination equaled the positive control (Vit E/Se). 
         FIG. 6 : illustrates the Mortality from days 27-35. The graphs illustrate the negative impact (increase) of heat stress on Mortality. In heat stressed animals, both the Vit E/Se positive control and the SOD/CAT combination reduced Mortality. 
         FIG. 7 : illustrates the body weight gain (BWG) from days 0-7. In heat stressed animals, both the Vit E/Se positive control and the SOD/CAT combination improved BWG. 
         FIG. 8 : illustrates the Conversion Ratio (FCR) from days 0-7. In heat-stressed animals, the effect of the SOD/CAT combination equaled the positive control (Vit E/Se). In heat stressed animals, both the Vit E/Se positive control and the SOD/CAT combination improved (reduced) FCR. 
         FIG. 9 : illustrates that SOD and CAT is associated with an increase in the expression of liver GPx (pre-heat stress) protein (d 27). 
         FIG. 10 : illustrates that SOD and CAT is associated with a reduction in the expression of Heat Shock Protein HSP70 in the jejunum (d28) The reduction in Heat Shock Protein is indicative od reduced inflammation. 
         FIG. 11 : illustrates that SOD and CAT is associated with a reduction in the expression of Heat Shock Protein HSP70 in the liver (d35). The reduction in Heat Shock Protein is indicative od reduced inflammation. 
         FIG. 12 : illustrates that SOD and CAT is associated with a reduction in the expression of liver iNOS prior to heat stress challenge (d27). Liver iNOS is a mediator of inflammation. 
         FIG. 13 : illustrates that SOD and CAT is associated with a reduction in the expression of liver IL-10 during heat stress (d 35), which qualifies as inflammatory marker. 
         FIG. 14 : illustrates that SOD and CAT is associated with a reduction in the expression of liver TNF alpha during heat stress (d 35), which qualifies as inflammatory marker. 
         FIG. 15 : illustrates that SOD and CAT is associated with a reduction in the expression of liver INF gamma during heat stress (d 35), which qualifies as inflammatory marker. 
         FIG. 16 : shows the basal diet for the piglets of the study 
         FIG. 17 : illustrates the Conversion Ratio (FCR) in piglets from days 0-42. There was significant difference observed in growth performance between positive and negative control. Catalase alone significantly improved the FCR. SOD alone significantly improved the FCR. The combination of the SOD and Catalase allowed for lower FCR or equally low FCR at lower doses. Combining SOD &amp; CAT or feeding CAT and SOD alone gave similar performance to the antibiotic treatment and significantly better than NC. 
         FIG. 18 : illustrates the body weight gain (BWG) in a second piglet trail from days 0-42. There was significant difference observed in growth performance between positive and negative control. 
         FIG. 19 : illustrates the Conversion Ratio (FCR) in the piglets of the second piglet trail from over the period of d0-d42. In particular, inclusion of SOD+CAT (independently of the candidate B or C) showed significant improvement on FCR performance. 
     
    
    
     OVERVIEW OF SEQUENCE LISTING 
     SEQ ID NO 1 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity from  Trichoderma reesei  comprising 287 amino acid residues. 
     SEQ ID NO 2 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity from  Aspergillus versicolor  comprising 186 amino acid residues 
     SEQ ID NO 3 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity from  Aspergillus deflectus  comprising 138 amino acid residues. 
     SEQ ID NO 4 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity from  Aspergillus egyptiacus  comprising 188 amino acid residues wherein residues 1 to 19 make up the signal peptide and residues 47 to 179 make up the SOD. 
     SEQ ID NO 5 is a polypeptide coding sequence of the polypeptide of SEQ ID NO: 1. 
     SEQ ID NO 6 is the amino acid sequence of a mature polypeptide having catalase activity from  Aspergillus niger  comprising 714 amino acid residues. 
     SEQ ID NO 7 is the amino acid sequence of a mature polypeptide having catalase activity from  Aspergillus niger  comprising 730 amino acid residues. SEQ ID NO 7 is sold under the tradename Catazyme™. 
     SEQ ID NO 8 is a polypeptide coding sequence from  Aspergillus niger  of the polypeptide of SEQ ID NO: 7. 
     SEQ ID NO 9 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Westerdykella  sp. AS85-2. 
     SEQ ID NO 10 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Aspergillus  sp. XZ2669. 
     SEQ ID NO 11 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity from  Preussia terricola.    
     SEQ ID NO 12 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Kionochaeta  sp. 
     SEQ ID NO 13 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Kionochaeta  sp. 
     SEQ ID NO 14 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Metapochonia bulbillosa.    
     SEQ ID NO 15 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Xylomelasma  sp. XZ0718. 
     SEQ ID NO 16 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Preussia flanaganii.    
     SEQ ID NO 17 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity) available from  Cladobotryum  sp. 
     SEQ ID NO 18 is a full-length amino acid sequence from the is the cDNA sequence of SEQ ID NO 98 from  Cladobotryum  sp. The signal start is amino acid residue 1 and the signal stop is amino acid residue 22. 
     SEQ ID NO 19 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Westerdykella  sp-46156. 
     SEQ ID NO 20 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Trichoderma  hamatum. 
     SEQ ID NO 21 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Mycothermus thermophilus.    
     SEQ ID NO 22 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Cephalotrichiella penicillate.    
     SEQ ID NO 23 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Chaetomium megalocarpum.    
     SEQ ID NO 24 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Chaetomium thermophilum  var.  thermophilum.    
     SEQ ID NO 25 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Humicola hyalothermophila.    
     SEQ ID NO 26 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Subramaniula anamorphosa.    
     SEQ ID NO 27 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Sphingobacterium  sp. T2. 
     SEQ ID NO 28 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Trichoderma  rossicum. 
     SEQ ID NO 29 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Trichoderma lixii.    
     SEQ ID NO 30 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Trichoderma  sp-54723. 
     SEQ ID NO 31 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Aspergillus niveus.    
     SEQ ID NO 32 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Aspergillus templicola.    
     SEQ ID NO 33 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Pochonia chlamydosporia  var.  spinulospora.    
     SEQ ID NO 34 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Trichoderma  sp-44174. 
     SEQ ID NO 35 is a full-length amino acid sequence from the is the cDNA sequence of SEQ ID NO 138 from  Trichoderma  sp-44174. The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. 
     SEQ ID NO 36 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Trichoderma  rossicum. 
     SEQ ID NO 37 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 139 from  Trichoderma rossicum . The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. 
     SEQ ID NO 38 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Trichoderma  sp-54723. 
     SEQ ID NO 39 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Trichoderma  sp-44174. 
     SEQ ID NO 40 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Metapochonia suchlasporia.    
     SEQ ID NO 41 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Metarhizium marquandii.    
     SEQ ID NO 42 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Diaporthe nobilis.    
     SEQ ID NO 43 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Tolypocladium  sp. XZ2627. 
     SEQ ID NO 44 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Aspergillus japonicus.    
     SEQ ID NO 45 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Metarhizium  sp. XZ2431. 
     SEQ ID NO 46 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Armillaria ostoyae.    
     SEQ ID NO 47 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Trichoderma  spirale. 
     SEQ ID NO 48 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Aspergillus elegans.    
     SEQ ID NO 49 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 90 from  Westerdykella  sp. AS85-2. The signal start is amino acid residue 1 and the signal stop is amino acid residue 18. 
     SEQ ID NO 50 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 91 from  Aspergillus  sp. XZ2669. The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. 
     SEQ ID NO 51 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 92 from  Preussia terricola . The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. 
     SEQ ID NO 52 is a full-length amino acid sequence from the is the cDNA sequence of SEQ ID NO 93 from  Kionochaeta  sp. The signal start is amino acid residue 1 and the signal stop is amino acid residue 18. 
     SEQ ID NO 53 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 94 from  Kionochaeta  sp. The signal start is amino acid residue 1 and the signal stop is amino acid residue 18. 
     SEQ ID NO 54 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 95 from  Metapochonia bulbillosa . The signal start is amino acid residue 1 and the signal stop is amino acid residue 17. 
     SEQ ID NO 55 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 96 from  Xylomelasma  sp. XZ0718. The signal start is amino acid residue 1 and the signal stop is amino acid residue 18. 
     SEQ ID NO 56 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 97 from  Preussia flanaganii . The signal start is amino acid residue 1 and the signal stop is amino acid residue 25. 
     SEQ ID NO 57 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 99 from  Westerdykella  sp-46156. The signal start is amino acid residue 1 and the signal stop is amino acid residue 18. 
     SEQ ID NO 58 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 100 from  Trichoderma hamatum . The signal start is amino acid residue 1 and the signal stop is amino acid residue 20. 
     SEQ ID NO 59 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 101 from  Mycothermus thermophilus.    
     SEQ ID NO 60 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 102 from  Cephalotrichiella penicillate . The signal start is amino acid residue 1 and the signal stop is amino acid residue 33. 
     SEQ ID NO 61 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 127 from  Chaetomium megalocarpum . The signal start is amino acid residue 1 and the signal stop is amino acid residue 37. 
     SEQ ID NO 62 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 128 from  Chaetomium thermophilum  var.  thermophilum . The signal start is amino acid residue 1 and the signal stop is amino acid residue 33. 
     SEQ ID NO 63 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 129 from  Humicola hyalothermophila . The signal start is amino acid residue 1 and the signal stop is amino acid residue 34. 
     SEQ ID NO 64 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 130 from  Subramaniula anamorphosa . The signal start is amino acid residue 1 and the signal stop is amino acid residue 36 (based signal alignment with other four Fe-SOD). 
     SEQ ID NO 65 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 131 from  Sphingobacterium  sp. T2. The signal start is residue 1 and the signal stop is residue 24. 
     SEQ ID NO 66 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 132 from  Trichoderma rossicum . The signal start is amino acid residue 1 and the signal stop is amino acid residue 24. 
     SEQ ID NO 67 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 133 from  Trichoderma lixii . The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. 
     SEQ ID NO 68 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 134 from  Trichoderma  sp-54723 The signal start is amino acid residue 1 and the signal stop is amino acid residue 20. 
     SEQ ID NO 69 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 135 from  Aspergillus niveus . The signal start is amino acid residue 1 and the signal stop is amino acid residue 16. 
     SEQ ID NO 70 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 136 from  Aspergillus templicola . The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. 
     SEQ ID NO 71 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 137 from  Pochonia chlamydosporia  var.  spinulospora . The signal start is amino acid residue 1 and the signal stop is amino acid residue 17. 
     SEQ ID NO 72 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 140 from  Trichoderma  sp-54723. The signal start is amino acid residue 1 and the signal stop is amino acid residue 20. 
     SEQ ID NO 73 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 141 from  Trichoderma  sp-44174 The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. 
     SEQ ID NO 74 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 142 from  Metapochonia suchlasporia . The signal start is amino acid residue 1 and the signal stop is amino acid residue 17. 
     SEQ ID NO 75 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 143 from  Metarhizium marquandii . The signal start is amino acid residue 1 and the signal stop is amino acid residue 17. 
     SEQ ID NO 76 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 144 from  Diaporthe nobilis . The signal start is amino acid residue 1 and the signal stop is amino acid residue 17. 
     SEQ ID NO 77 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 145 from  Tolypocladium  sp. XZ2627. The signal start is amino acid residue 1 and the signal stop is amino acid residue 20. 
     SEQ ID NO 78 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 146 from  Aspergillus japonicus  The signal start is amino acid residue 1 and the signal stop is amino acid residue 21. 
     SEQ ID NO 79 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 147 from  Metarhizium  sp. XZ2431. The signal start is amino acid residue 1 and the signal stop is amino acid residue 16. 
     SEQ ID NO 80 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 148 from  Armillaria ostoyae . The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. 
     SEQ ID NO 81 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 149 from  Trichoderma spirale . The signal start is amino acid residue 1 and the signal stop is amino acid residue 19 
     SEQ ID NO 82 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 150 from  Aspergillus elegans . The signal start is amino acid residue 1 and the signal stop is amino acid residue 22. 
     SEQ ID NO 83 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 5 from  Trichoderma reesei . The signal start is amino acid residue 1 and the signal stop is amino acid residue 20. 
     SEQ ID NO 84 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 87 from  Aspergillus versicolor . The signal start is amino acid residue 1 and the signal stop is amino acid residue 20. 
     SEQ ID NO 85 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 88 from  Aspergillus deflectus . The signal start is amino acid residue 1 and the signal stop is amino acid residue 16. 
     SEQ ID NO 86 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 89 from  Aspergillus egyptiacus . The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. 
     SEQ ID NO 87 is a polypeptide coding sequence from  Aspergillus versicolor  of the polypeptide of SEQ ID NO 84. 
     SEQ ID NO 88 is a polypeptide coding sequence from  Aspergillus deflectus  of the polypeptide of SEQ ID NO 85. 
     SEQ ID NO 89 is a polypeptide coding sequence from  Aspergillus egyptiacus  of the polypeptide of SEQ ID NO 86. 
     SEQ ID NO 90 is a polypeptide coding sequence from  Westerdykella  sp. AS85-2 of the polypeptide of SEQ ID NO: 49. 
     SEQ ID NO 91 is a polypeptide coding sequence from  Aspergillus  sp. XZ2669 of the polypeptide of SEQ ID NO: 50. 
     SEQ ID NO 92 is a polypeptide coding sequence from  Preussia terricola  of the polypeptide of 
     SEQ ID NO 51. 
     SEQ ID NO 93 is a polypeptide coding sequence from  Kionochaeta  sp. of the polypeptide of SEQ ID NO: 52. 
     SEQ ID NO 94 is a polypeptide coding sequence from  Kionochaeta  sp. of the polypeptide of SEQ ID NO 53. 
     SEQ ID NO 95 is a polypeptide coding sequence from  Metapochonia bulbillosa  of the polypeptide of SEQ ID NO 54. 
     SEQ ID NO 96 is a polypeptide coding sequence from  Xylomelasma  sp. XZ0718 of the polypeptide of SEQ ID NO: 55. 
     SEQ ID NO 97 is a polypeptide coding sequence from  Preussia flanaganii  of the polypeptide of 
     SEQ ID NO: 56. 
     SEQ ID NO 98 is a polypeptide coding sequence from  Cladobotryum  sp. of the polypeptide of SEQ ID NO: 18. 
     SEQ ID NO 99 is a polypeptide coding sequence from  Westerdykella  sp-46156 of the polypeptide of SEQ ID NO: 57. 
     SEQ ID NO 100 is a polypeptide coding sequence from  Trichoderma hamatum  of the polypeptide of SEQ ID NO: 58. 
     SEQ ID NO 101 is a polypeptide coding sequence from  Mycothermus thermophilus  of the SEQ ID NO 102 is a polypeptide coding sequence from  Cephalotrichiella penicillate  of the polypeptide of SEQ ID NO: 160. 
     SEQ ID NO 103 is the amino acid sequence of a mature polypeptide having catalase activity available from  Thermoascus aurantiacus.    
     SEQ ID NO 104 is the amino acid sequence of a mature polypeptide having catalase activity available from  Aspergillus lentulus.    
     SEQ ID NO 105 is the amino acid sequence of a mature polypeptide having catalase activity available from  Talaromyces stipitatus.    
     SEQ ID NO 106 is the amino acid sequence of a mature polypeptide having catalase activity available from  Malbranchea cinnamomea.    
     SEQ ID NO 107 is the amino acid sequence of a mature polypeptide having catalase activity available from  Crassicarpon thermophilum.    
     SEQ ID NO 108 is the amino acid sequence of a mature polypeptide having catalase activity available from  Penicillium emersonii.    
     SEQ ID NO 109 is the amino acid sequence of a mature polypeptide having catalase activity available from  Aspergillus versicolor.    
     SEQ ID NO 110 is the amino acid sequence of a mature polypeptide having catalase activity available from  Thermomucor indicae - seudaticae.    
     SEQ ID NO 111 is the amino acid sequence of a mature polypeptide having activity available from  Aspergillus fumigatus.    
     SEQ ID NO 112 is the amino acid sequence of a mature polypeptide having catalase activity available from  Thermothelomyces thermophilus.    
     SEQ ID NO 113 is the amino acid sequence of a mature polypeptide having catalase activity available from  Curvularia verruculosa.    
     SEQ ID NO 114 is the amino acid sequence of a mature polypeptide having catalase activity available from  Mycothermus thermophilus    
     SEQ ID NO 115 is the amino acid sequence of a mature polypeptide having catalase activity available from  Mycothermus thermophilus.    
     SEQ ID NO 116 is the amino acid sequence of a mature polypeptide having catalase activity available from  Penicillium oxalicum.    
     SEQ ID NO 117 is the amino acid sequence of a mature polypeptide having catalase activity available from  Humicola hyalothermophila.    
     SEQ ID NO 118 is the amino acid sequence of a mature polypeptide having catalase activity available from  Thermoascus crustaceus.    
     SEQ ID NO 119 is the amino acid sequence of a mature polypeptide having catalase activity available from  Thielavia australiensis.    
     SEQ ID NO 120 is the amino acid sequence of a mature polypeptide having catalase activity available from  Thielavia hyrcaniae.    
     SEQ ID NO 121 is the amino acid sequence of a mature polypeptide having catalase activity available from  Neurospora crassa.    
     SEQ ID NO 122 is the amino acid sequence of a mature polypeptide having catalase activity available from  Thermoascus aurantiacus.    
     SEQ ID NO 123 is the amino acid sequence of a mature polypeptide having catalase activity available from  Neurospora crassa.    
     SEQ ID NO 124 is the amino acid sequence of a mature polypeptide having catalase activity available from  Thermoascus aurantiacus.    
     SEQ ID NO 125 is the amino acid sequence of a mature polypeptide having catalase activity available from  Thermoascus aurantiacus.    
     SEQ ID NO 126 is the amino acid sequence of a mature polypeptide having catalase activity available from  Thermoascus aurantiacus.    
     SEQ ID NO 127 is a polypeptide coding sequence from  Chaetomium megalocarpum  of the polypeptide of SEQ ID NO 23. 
     SEQ ID NO 128 is a polypeptide coding sequence from  Chaetomium thermophilum  var.  thermophilum  of the polypeptide of SEQ ID NO: 24. 
     SEQ ID NO 129 is a polypeptide coding sequence from  Humicola hyalothermophila  of the polypeptide of SEQ ID NO: 25. 
     SEQ ID NO 130 is a polypeptide coding sequence from  Subramaniula anamorphosa  of the polypeptide of SEQ ID NO: 26. 
     SEQ ID NO 131 is a polypeptide coding sequence from  Sphingobacterium  sp. T2 of the polypeptide of SEQ ID NO 27. 
     SEQ ID NO 132 is a polypeptide coding sequence from  Trichoderma rossicum  of the polypeptide of SEQ ID NO 28. 
     SEQ ID NO 133 is a polypeptide coding sequence from  Trichoderma lixii  of the polypeptide of SEQ ID NO 29. 
     SEQ ID NO 134 is a polypeptide coding sequence from  Trichoderma  sp-54723 of the polypeptide of SEQ ID NO 30. 
     SEQ ID NO 135 is a polypeptide coding sequence from  Aspergillus niveus  of the polypeptide of 
     SEQ ID NO 31. 
     SEQ ID NO 136 is a polypeptide coding sequence from  Aspergillus templicola  of the polypeptide of SEQ ID NO 32. 
     SEQ ID NO 137 is a polypeptide coding sequence from  Pochonia chlamydosporia  var.  spinulospora  of the polypeptide of SEQ ID NO 33. 
     SEQ ID NO 138 is a polypeptide coding sequence from  Trichoderma  sp-44174 of the polypeptide of SEQ ID NO 34. 
     SEQ ID NO 139 is a polypeptide coding sequence from  Trichoderma rossicum  of the polypeptide of SEQ ID NO 36. 
     SEQ ID NO 140 is a polypeptide coding sequence from  Trichoderma  sp-54723 of the polypeptide of SEQ ID NO: 38. 
     SEQ ID NO 141 is a polypeptide coding sequence from  Trichoderma  sp-44174 of the polypeptide of SEQ ID NO: 39. 
     SEQ ID NO 142 is a polypeptide coding sequence from  Metapochonia suchlasporia  of the polypeptide of SEQ ID NO: 40. 
     SEQ ID NO 143 is a polypeptide coding sequence from  Metarhizium marquandii  of the polypeptide of SEQ ID NO 41. 
     SEQ ID NO 144 is a polypeptide coding sequence from  Diaporthe nobilis  of the polypeptide of 
     SEQ ID NO 42. 
     SEQ ID NO 145 is a polypeptide coding sequence from  Tolypocladium  sp. XZ2627 of the polypeptide of SEQ ID NO 43. 
     SEQ ID NO 146 is a polypeptide coding sequence from  Tolypocladium  sp. XZ2627 of the polypeptide of SEQ ID NO 44. 
     SEQ ID NO 147 is a polypeptide coding sequence from  Metarhizium  sp. XZ2431 of the polypeptide of SEQ ID NO 45. 
     SEQ ID NO 148 is a polypeptide coding sequence from  Armillaria ostoyae  of the polypeptide of SEQ ID NO 46. 
     SEQ ID NO 149 is a polypeptide coding sequence from  Trichoderma spirale  of the polypeptide of SEQ ID NO 47. 
     SEQ ID NO 150 is a polypeptide coding sequence from  Aspergillus elegans  of the polypeptide of SEQ ID NO 48. 
     SEQ ID NO 151 is a full-length amino acid sequence of a polypeptide with catalase activity from the cDNA sequence of SEQ ID NO 175 from  Thermoascus aurantiacus.    
     SEQ ID NO 152 is a full-length amino acid sequence of a polypeptide with catalase activity from the cDNA sequence of SEQ ID 176 from  Aspergillus lentulus.    
     SEQ ID NO 153 is a full-length amino acid sequence of a polypeptide with catalase activity from the cDNA sequence of SEQ ID 177 from  Talaromyces stipitatus    
     SEQ ID NO 154 is a full-length amino acid sequence of a polypeptide with catalase activity from the cDNA sequence of SEQ ID 178 from  Malbranchea cinnamomea.    
     SEQ ID NO 155 is a full-length amino acid sequence of a polypeptide with catalase activity from the cDNA sequence of SEQ ID 179  Crassicarpon thermophilum.    
     SEQ ID NO 156 is a full-length amino acid sequence of a polypeptide with catalase activity from the cDNA sequence of SEQ ID 180 from  Penicillium emersonii.    
     SEQ ID NO 157 is a full-length amino acid sequence of a polypeptide with catalase activity from the cDNA sequence of SEQ ID 181 from  Aspergillus versicolor.    
     SEQ ID NO 158 is a full-length amino acid sequence of a polypeptide with catalase activity from the cDNA sequence of SEQ ID 182 from  Thermomucor indicae - seudaticae    
     SEQ ID NO 159 is a full-length amino acid sequence of a polypeptide with catalase activity from the cDNA sequence of SEQ ID 183 from  Aspergillus fumigatus    
     SEQ ID NO 160 is a full-length amino acid sequence of a polypeptide with catalase activity from the cDNA sequence of SEQ ID 184 from  Thermothelomyces thermophilus.    
     SEQ ID NO 161 is a full-length amino acid sequence of a polypeptide with catalase activity from the cDNA sequence of SEQ ID 185 from  Curvularia verruculosa.    
     SEQ ID NO 162 is a full-length amino acid sequence of a polypeptide with catalase activity from the cDNA sequence of SEQ ID 186 from  Mycothermus thermophilus.    
     SEQ ID NO 163 is a full-length amino acid sequence with catalase activity from the cDNA sequence of SEQ ID 187 from  Mycothermus thermophilus.    
     SEQ ID NO 164 is a full-length amino acid sequence with catalase activity from the cDNA sequence of SEQ ID 188 from  Penicillium oxalicum    
     SEQ ID NO 165 is a full-length amino acid sequence with catalase activity from the cDNA sequence of SEQ ID 189 from  Humicola hyalothermophila.    
     SEQ ID NO 166 is a full-length amino acid sequence with catalase activity from the cDNA sequence of SEQ ID 190 from  Thermoascus crustaceus.    
     SEQ ID NO 167 is a full-length amino acid sequence with catalase activity from the cDNA sequence of SEQ ID 191 from  Thielavia australiensis.    
     SEQ ID NO 168 is a full-length amino acid sequence with catalase activity from the cDNA sequence of SEQ ID 192 from  Thielavia hyrcaniae.    
     SEQ ID NO 169 is a full-length amino acid sequence with catalase activity from the cDNA sequence of SEQ ID 193 from  Neurospora crassa.    
     SEQ ID NO 170 is a full-length amino acid sequence with catalase activity from the cDNA sequence of SEQ ID 194 from  Thermoascus aurantiacus.    
     SEQ ID NO 171 is a full-length amino acid sequence with catalase activity from the cDNA sequence of SEQ ID 195 from  Neurospora crassa.    
     SEQ ID NO 172 is a full-length amino acid sequence with catalase activity from the cDNA sequence of SEQ ID 196 from  Thermoascus aurantiacus.    
     SEQ ID NO 173 is a full-length amino acid sequence with catalase activity from the cDNA sequence of SEQ ID 197 from  Thermoascus aurantiacus.    
     SEQ ID NO 174 is a full-length amino acid sequence with catalase activity from the cDNA sequence of SEQ ID 198 from  Thermoascus aurantiacus.    
     SEQ ID NO 175 is a polypeptide coding sequence from  Thermoascus aurantiacus  coding for the polypeptide of SEQ ID NO 151. 
     SEQ ID NO 176 is a polypeptide coding sequence from  Aspergillus lentulus  coding for the polypeptide of SEQ ID NO 152. 
     SEQ ID NO 177 is a polypeptide coding sequence from  Talaromyces stipitatus  coding for the polypeptide of SEQ ID NO 153. 
     SEQ ID NO 178 is a polypeptide coding sequence from  Malbranchea cinnamomea  coding for the polypeptide of SEQ ID NO 154. 
     SEQ ID NO 179 is a polypeptide coding sequence from  Crassicarpon thermophilum  coding for the polypeptide of SEQ ID NO 155. 
     SEQ ID NO 180 is a polypeptide coding sequence from  Penicillium emersonii  coding for the polypeptide of SEQ ID NO 156. 
     SEQ ID NO 181 is a polypeptide coding sequence from  Aspergillus versicolor  coding for the polypeptide of SEQ ID NO 157. 
     SEQ ID NO 182 is a polypeptide coding sequence from  Thermomucor indicae - seudaticae  coding for the polypeptide of SEQ ID NO 158. 
     SEQ ID NO 183 is a polypeptide coding sequence from  Aspergillus fumigatus  coding for the polypeptide of SEQ ID NO 159. 
     SEQ ID NO 184 is a polypeptide coding sequence from  Thermothelomyces thermophilus  coding for the polypeptide of SEQ ID NO 160. 
     SEQ ID NO 185 is a polypeptide coding sequence from  Curvularia verruculosa  coding for the polypeptide of SEQ ID NO 161. 
     SEQ ID NO 186 is a polypeptide coding sequence from  Mycothermus thermophilus  coding for the polypeptide of SEQ ID NO 162. 
     SEQ ID NO 187 is a polypeptide coding sequence from  Mycothermus thermophilus  coding for the polypeptide of SEQ ID NO 163. 
     SEQ ID NO 188 is a polypeptide coding sequence from  Penicillium oxalicum  coding for the polypeptide of SEQ ID NO 164. 
     SEQ ID NO 189 is a polypeptide coding sequence from  Humicola hyalothermophila  coding for the polypeptide of SEQ ID NO 165. 
     SEQ ID NO 190 is a polypeptide coding sequence from  Thermoascus crustaceus  coding for the polypeptide of SEQ ID NO 160. 
     SEQ ID NO 191 is a polypeptide coding sequence from  Thielavia australiensis  coding for the polypeptide of SEQ ID NO 167. 
     SEQ ID NO 192 is a polypeptide coding sequence from  Thielavia hyrcaniae  coding for the polypeptide of SEQ ID NO 168. 
     SEQ ID NO 193 is a polypeptide coding sequence from  Neurospora crassa  coding for the polypeptide of SEQ ID NO 169. 
     SEQ ID NO 194 is a polypeptide coding sequence from  Thermoascus aurantiacus  coding for the polypeptide of SEQ ID NO 170. 
     SEQ ID NO 195 is a polypeptide coding sequence from  Neurospora crassa  coding for the polypeptide of SEQ ID NO 171. 
     SEQ ID NO 196 is a polypeptide coding sequence from  Thermoascus aurantiacus  coding for the polypeptide of SEQ ID NO 172. 
     SEQ ID NO 197 is a polypeptide coding sequence from  Thermoascus aurantiacus  coding for the polypeptide of SEQ ID NO 173. 
     SEQ ID NO 198 is a polypeptide coding sequence from  Thermoascus aurantiacus  coding for the polypeptide of SEQ ID NO 174. 
     SEQ ID NO 199 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Trichoderma sinuosum  (O434SD). 
     SEQ ID NO 200 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Trichoderma virens  (O32VB5). 
     SEQ ID NO 201 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Trichoderma harzianum  (O4). 
     SEQ ID NO 202 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Fusicolla acetilerea.    
     SEQ ID NO 203 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Plectosphaerella  sp. 1-29. 
     SEQ ID NO 204 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Mariannaea punicea.    
     SEQ ID NO 205 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Penicillium oxalicum.    
     SEQ ID NO 206 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Colletotrichum  sp-71086. 
     SEQ ID NO 207 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Aspergillus  sp.  nov . XZ3202. 
     SEQ ID NO 208 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Trichoderma parapiluliferum.    
     SEQ ID NO 209 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity available from  Aspergillus  sp.  nov . XZ3202. 
     SEQ ID NO 210 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 221 from  Trichoderma sinuosum . The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. 
     SEQ ID NO 211 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 222 from  Trichoderma virens . The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. 
     SEQ ID NO 212 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 223 from  Trichoderma harzianum . The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. 
     SEQ ID NO 213 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 224 from  Fusicolla acetilerea . The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. With no native signal, a signal and propeptide was added at its N-terminal, and MVK was removed from the N-terminal. 
     SEQ ID NO 214 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 225 from  Plectosphaerella  sp. 1-29. 
     SEQ ID NO 215 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 226 from  Mariannaea punicea.    
     SEQ ID NO 216 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 227 from  Penicillium oxalicum.    
     SEQ ID NO 217 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 228 from  Colletotrichum  sp-71086. The signal start is amino acid residue 1 and the signal stop is amino acid residue 20. 
     SEQ ID NO 218 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 229 from  Aspergillus  sp.  nov . XZ3202. The signal start is amino acid residue 1 and the signal stop is amino acid residue 16. 
     SEQ ID NO 219 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 230 from  Trichoderma parapiluliferum . The signal start is amino acid residue 1 and the signal stop is amino acid residue 18. 
     SEQ ID NO 220 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 231 from  Aspergillus  sp.  nov . XZ3202. The signal start is amino acid residue 1 and the signal stop is amino acid residue 19. 
     SEQ ID NO 221 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 210 from  Trichoderma sinuosum.    
     SEQ ID NO 222 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 211 from  Trichoderma virens.    
     SEQ ID NO 223 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 212 from  Trichoderma harzianum.    
     SEQ ID NO 224 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 213 from  Fusicolla acetilerea.    
     SEQ ID NO 225 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 214 from  Plectosphaerella  sp. 1-29. 
     SEQ ID NO 226 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 215 from  Mariannaea punicea.    
     SEQ ID NO 227 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 216 from  Penicillium oxalicum.    
     SEQ ID NO 228 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 217 from  Colletotrichum  sp-71086. 
     SEQ ID NO 229 is a polypeptide coding sequence of the polypeptide of SEQ ID NO: 218 from  Aspergillus  sp.  nov . XZ3202 (O14ETD). 
     SEQ ID NO 230 is a polypeptide coding sequence of the polypeptide of SEQ ID NO: 219 from  Trichoderma parapiluliferum  (O72ZVS). 
     SEQ ID NO 231 is a polypeptide coding sequence of the polypeptide of SEQ ID NO: 220 from  Aspergillus  sp.  nov . XZ3202. 
     SEQ ID NO 232 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity from  Mucor  sp. XZ2651. 
     SEQ ID NO 233 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity from  Rhizomucor miehei.    
     SEQ ID NO 234 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity from  Mucor  sp. XZ2651. 
     SEQ ID NO 235 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity from Amphisphaeriaceae sp-43674. 
     SEQ ID NO 236 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity from  Humicola fuscoatra.    
     SEQ ID NO 237 is the amino acid sequence of a mature polypeptide having superoxide dismutase (SOD) activity from  Valsaria rubricosa.    
     SEQ ID NO 238 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 244 DNA from  Mucor  sp. XZ2651. The signal start is amino acid residue 1 and the signal stop is amino acid residue 17. 
     SEQ ID NO 239 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 245 DNA from  Rhizomucor miehei . The signal start is amino acid residue 1 and the signal stop is amino acid residue 13. 
     SEQ ID NO 240 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 246 DNA from  Mucor  sp. XZ2651. The signal start is amino acid residue 1 and the signal stop is amino acid residue 17. 
     SEQ ID NO 241 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 247 DNA from Amphisphaeriaceae sp-43674. The signal start is amino acid residue 1 and the signal stop is amino acid residue 18. 
     SEQ ID NO 242 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 248 DNA from  Humicola fuscoatra . The signal start is amino acid residue 1 and the signal stop is amino acid residue 17. 
     SEQ ID NO 243 is a full-length amino acid sequence from the cDNA sequence of SEQ ID NO 249 DNA from  Valsaria rubricosa . The signal start is amino acid residue 1 and the signal stop is amino acid residue 18. 
     SEQ ID NO 244 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 238 from  Mucor  sp. XZ2651. 
     SEQ ID NO 245 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 239 from  Rhizomucor miehei    
     SEQ ID NO 246 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 240 from  Mucor  sp. XZ2651. 
     SEQ ID NO 247 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 241 from Amphisphaeriaceae sp-43674. 
     SEQ ID NO 248 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 242 from from  Humicola fuscoatra.    
     SEQ ID NO 249 is a polypeptide coding sequence of the polypeptide of SEQ ID NO 243 from  Valsaria rubricosa.    
     SEQ ID NO 250 is the amino acid sequence of a mature polypeptide having catalase activity from  Thermoascus aurantiacus  comprising 724 amino acid residues. SEQ ID NO 250 the mature polypeptide of the catalase sold under the tradename Terminox™. 
     SEQ ID NO 251 is a full-length amino acid sequence of a polypeptide from  Thermoascus aurantiacus  having catalase activity comprising 740 amino acid residues, sold under the tradename Terminox™. The signal start is amino acid residue 1 and the signal stop is amino acid residue 16. 
     
       
         
           
               
             
               
                 TABLE 1a 
               
             
            
               
                   
               
               
                 Super Oxide Dismutases and their polypeptide coding sequences 
               
            
           
           
               
               
               
               
            
               
                   
                 SEQ ID NO 
                 SEQ ID NO 
                 SEQ ID NO 
               
               
                 Source 
                 Mature peptide 
                 Full polypeptide 
                 DNA 
               
               
                   
               
               
                 
                   Trichoderma reesei 
                 
                 SED ID NO 1 
                 SEQ ID NO 83 
                 SEQ ID NO 5 
               
               
                 
                   Aspergillus versicolor 
                 
                 SED ID NO 2 
                 SEQ ID NO 84 
                 SEQ ID NO 87 
               
               
                 
                   Aspergillus deflectus 
                 
                 SEQ ID NO 3 
                 SEQ ID NO 85 
                 SEQ ID NO 88 
               
               
                 
                   Aspergillus egyptiacus 
                 
                 SEQ ID NO 4 
                 SEQ ID NO 86 
                 SEQ ID NO 89 
               
               
                   Westerdykella  sp. AS85-2 
                 SEQ ID NO 9 
                 SEQ ID NO 49 
                 SEQ ID NO 90 
               
               
                   Aspergillus  sp. XZ2669 
                 SEQ ID NO 10 
                 SEQ ID NO 50 
                 SEQ ID NO 91 
               
               
                 
                   Preussia terricola 
                 
                 SEQ ID NO 11 
                 SEQ ID NO 51 
                 SEQ ID NO 92 
               
               
                   Kionochaeta  sp. 
                 SEQ ID NO 12 
                 SEQ ID NO 52 
                 SEQ ID NO 93 
               
               
                   Kionochaeta  sp. 
                 SEQ ID NO 13 
                 SEQ ID NO 53 
                 SEQ ID NO 94 
               
               
                 Metapochonia bulbillosa 
                 SEQ ID NO 14 
                 SEQ ID NO 54 
                 SEQ ID NO 95 
               
               
                   Xylomelasma  sp. XZ0718 
                 SEQ ID NO 15 
                 SEQ ID NO 55 
                 SEQ ID NO 96 
               
               
                 
                   Preussia flanaganii 
                 
                 SEQ ID NO 16 
                 SEQ ID NO 56 
                 SEQ ID NO 97 
               
               
                   Cladobotryum  sp. 
                 SEQ ID NO 17 
                 SEQ ID NO 18 
                 SEQ ID NO 98 
               
               
                   Westerdykella  sp-46156 
                 SEQ ID NO 19 
                 SEQ ID NO 57 
                 SEQ ID NO 99 
               
               
                 
                   Trichoderma hamatum 
                 
                 SEQ ID NO 20 
                 SEQ ID NO 58 
                 SEQ ID NO 100 
               
               
                 Mycothermus thermophilus 
                 SEQ ID NO 21 
                 SEQ ID NO 59 
                 SEQ ID NO 101 
               
               
                 
                   Cephalotrichiella penicillata 
                 
                 SEQ ID NO 22 
                 SEQ ID NO 60 
                 SEQ ID NO 102 
               
               
                 
                   Chaetomium megalocarpum 
                 
                 SEQ ID NO 23 
                 SEQ ID NO 61 
                 SEQ ID NO 127 
               
               
                 
                   Chaetomium thermophilum 
                 
                 SEQ ID NO 24 
                 SEQ ID NO 62 
                 SEQ ID NO 128 
               
               
                 var.  thermophilum   
               
               
                 
                   Humicola hyalothermophila 
                 
                 SEQ ID NO 25 
                 SEQ ID NO 63 
                 SEQ ID NO 129 
               
               
                 
                   Subramaniula anamorphosa 
                 
                 SEQ ID NO 26 
                 SEQ ID NO 64 
                 SEQ ID NO 130 
               
               
                   Sphingobacterium  sp. T2 
                 SEQ ID NO 27 
                 SEQ ID NO 65 
                 SEQ ID NO 131 
               
               
                 
                   Trichoderma rossicum 
                 
                 SEQ ID NO 28 
                 SEQ ID NO 66 
                 SEQ ID NO 132 
               
               
                 
                   Trichoderma lixii 
                 
                 SEQ ID NO 29 
                 SEQ ID NO 67 
                 SEQ ID NO 133 
               
               
                   Trichoderma  sp-54723 
                 SEQ ID NO 30 
                 SEQ ID NO 68 
                 SEQ ID NO 134 
               
               
                 
                   Aspergillus niveus 
                 
                 SEQ ID NO 31 
                 SEQ ID NO 69 
                 SEQ ID NO 135 
               
               
                 
                   Aspergillus templicola 
                 
                 SEQ ID NO 32 
                 SEQ ID NO 70 
                 SEQ ID NO 136 
               
               
                 
                   Pochonia chlamydosporia 
                 
                 SEQ ID NO 33 
                 SEQ ID NO 71 
                 SEQ ID NO 137 
               
               
                 var.  spinulospora   
               
               
                   Trichoderma  sp-44174 
                 SEQ ID NO 34 
                 SEQ ID NO 35 
                 SEQ ID NO 138 
               
               
                 
                   Trichoderma rossicum 
                 
                 SEQ ID NO 36 
                 SEQ ID NO 37 
                 SEQ ID NO 139 
               
               
                   Trichoderma  sp-54723 
                 SEQ ID NO 38 
                 SEQ ID NO 72 
                 SEQ ID NO 140 
               
               
                   Trichoderma  sp-44174 
                 SEQ ID NO 39 
                 SEQ ID NO 73 
                 SEQ ID NO 141 
               
               
                 Metapochonia suchlasporia 
                 SEQ ID NO 40 
                 SEQ ID NO 74 
                 SEQ ID NO 142 
               
               
                 
                   Metarhizium marquandii 
                 
                 SEQ ID NO 41 
                 SEQ ID NO 75 
                 SEQ ID NO 143 
               
               
                 
                   Diaporthe nobilis 
                 
                 SEQ ID NO 42 
                 SEQ ID NO 76 
                 SEQ ID NO 144 
               
               
                   Tolypocladium  sp. XZ2627 
                 SEQ ID NO 43 
                 SEQ ID NO 77 
                 SEQ ID NO 145 
               
               
                 
                   Aspergillus japonicus 
                 
                 SEQ ID NO 44 
                 SEQ ID NO 78 
                 SEQ ID NO 146 
               
               
                   Metarhizium  sp. XZ2431 
                 SEQ ID NO 45 
                 SEQ ID NO 79 
                 SEQ ID NO 147 
               
               
                 Armillaria ostoyae 
                 SEQ ID NO 46 
                 SEQ ID NO 80 
                 SEQ ID NO 148 
               
               
                 
                   Trichoderma spirale 
                 
                 SEQ ID NO 47 
                 SEQ ID NO 81 
                 SEQ ID NO 149 
               
               
                 
                   Aspergillus elegans 
                 
                 SEQ ID NO 48 
                 SEQ ID NO 82 
                 SEQ ID NO 150 
               
               
                 
                   Trichoderma sinuosum 
                 
                 SEQ ID NO 199 
                 SEQ ID NO 210 
                 SEQ ID NO 221 
               
               
                 
                   Trichoderma virens 
                 
                 SEQ ID NO 200 
                 SEQ ID NO 211 
                 SEQ ID NO 222 
               
               
                 
                   Trichoderma harzianum 
                 
                 SEQ ID NO 201 
                 SEQ ID NO 212 
                 SEQ ID NO 223 
               
               
                 Fusicolla acetilerea 
                 SEQ ID NO 202 
                 SEQ ID NO 213 
                 SEQ ID NO 224 
               
               
                   Plectosphaerella  sp. 1-29 
                 SEQ ID NO 203 
                 SEQ ID NO 214 
                 SEQ ID NO 225 
               
               
                 Mariannaea punicea 
                 SEQ ID NO 204 
                 SEQ ID NO 215 
                 SEQ ID NO 226 
               
               
                 Penicillium oxalicum 
                 SEQ ID NO 205 
                 SEQ ID NO 216 
                 SEQ ID NO 227 
               
               
                   Colletotrichum  sp-71086 
                 SEQ ID NO 206 
                 SEQ ID NO 217 
                 SEQ ID NO 228 
               
               
                   Aspergillus  sp. nov. 
                 SEQ ID NO 207 
                 SEQ ID NO 218 
                 SEQ ID NO 229 
               
               
                 XZ3202 
               
               
                 
                   Trichoderma 
                 
                 SEQ ID NO 208 
                 SEQ ID NO 219 
                 SEQ ID NO 230 
               
               
                 
                   parapiluliferum 
                 
               
               
                   Aspergillus  sp. nov. 
                 SEQ ID NO 209 
                 SEQ ID NO 220 
                 SEQ ID NO 231 
               
               
                 XZ3202 
               
               
                   Mucor  sp. XZ2651 
                 SEQ ID NO 232 
                 SEQ ID NO 238 
                 SEQ ID NO 244 
               
               
                 Rhizomucor miehei 
                 SEQ ID NO 233 
                 SEQ ID NO 239 
                 SEQ ID NO 245 
               
               
                   Mucor  sp. XZ2651 
                 SEQ ID NO 234 
                 SEQ ID NO 240 
                 SEQ ID NO 246 
               
               
                 Amphisphaeriaceae -sp 
                 SEQ ID NO 235 
                 SEQ ID NO 241 
                 SEQ ID NO 247 
               
               
                 43674 
               
               
                 
                   Humicola fuscoatra 
                 
                 SEQ ID NO 236 
                 SEQ ID NO 242 
                 SEQ ID NO 248 
               
               
                 Valsaria rubricosa 
                 SEQ ID NO 237 
                 SEQ ID NO 243 
                 SEQ ID NO 249 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 1b 
               
             
            
               
                   
               
               
                 Catalases and their polypeptide coding sequences 
               
            
           
           
               
               
               
               
            
               
                   
                 SEQ ID NO 
                 SEQ ID NO 
                 SEQ ID NO 
               
               
                 Source 
                 Mature peptide 
                 Full polypeptide 
                 DNA 
               
               
                   
               
               
                 
                   Aspergillus niger 
                 
                 SEQ ID NO 6 
                 na 
                 na 
               
               
                 
                   Aspergillus niger 
                 
                 SEQ ID NO 7 
                 na 
                 SEQ ID NO 8 
               
               
                 Thermoascus aurantiacus 
                 SEQ ID NO 103 
                 SEQ ID NO 151 
                 SEQ ID NO 175 
               
               
                 
                   Aspergillus lentulus 
                 
                 SEQ ID NO 104 
                 SEQ ID NO 152 
                 SEQ ID NO 176 
               
               
                 Talaromyces stipitatus 
                 SEQ ID NO 105 
                 SEQ ID NO 153 
                 SEQ ID NO 177 
               
               
                 Malbranchea cinnamomea 
                 SEQ ID NO 106 
                 SEQ ID NO 154 
                 SEQ ID NO 178 
               
               
                 Crassicarpon thermophilum 
                 SEQ ID NO 107 
                 SEQ ID NO 155 
                 SEQ ID NO 179 
               
               
                 Penicillium emersonii 
                 SEQ ID NO 108 
                 SEQ ID NO 156 
                 SEQ ID NO 180 
               
               
                 
                   Aspergillus versicolor 
                 
                 SEQ ID NO 109 
                 SEQ ID NO 157 
                 SEQ ID NO 181 
               
               
                 Thermomucor indicae- 
                 SEQ ID NO 110 
                 SEQ ID NO 158 
                 SEQ ID NO 182 
               
               
                 seudaticae 
               
               
                 
                   Aspergillus fumigatus 
                 
                 SEQ ID NO 111 
                 SEQ ID NO 159 
                 SEQ ID NO 183 
               
               
                 Thermothelomyces 
                 SEQ ID NO 112 
                 SEQ ID NO 160 
                 SEQ ID NO 184 
               
               
                 thermophilus 
               
               
                 Curvularia verruculosa 
                 SEQ ID NO 113 
                 SEQ ID NO 161 
                 SEQ ID NO 185 
               
               
                 Mycothermus thermophilus 
                 SEQ ID NO 114 
                 SEQ ID NO 162 
                 SEQ ID NO 186 
               
               
                 Mycothermus thermophilus 
                 SEQ ID NO 115 
                 SEQ ID NO 163 
                 SEQ ID NO 187 
               
               
                 Penicillium oxalicum 
                 SEQ ID NO 116 
                 SEQ ID NO 164 
                 SEQ ID NO 188 
               
               
                 
                   Humicola hyalothermophila 
                 
                 SEQ ID NO 117 
                 SEQ ID NO 165 
                 SEQ ID NO 189 
               
               
                 Thermoascus crustaceus 
                 SEQ ID NO 118 
                 SEQ ID NO 166 
                 SEQ ID NO 190 
               
               
                 Thielavia australiensis 
                 SEQ ID NO 119 
                 SEQ ID NO 167 
                 SEQ ID NO 191 
               
               
                 Thielavia hyrcaniae 
                 SEQ ID NO 120 
                 SEQ ID NO 168 
                 SEQ ID NO 192 
               
               
                 Neurospora crassa 
                 SEQ ID NO 121 
                 SEQ ID NO 169 
                 SEQ ID NO 193 
               
               
                 Thermoascus aurantiacus 
                 SEQ ID NO 122 
                 SEQ ID NO 170 
                 SEQ ID NO 194 
               
               
                 Neurospora crassa 
                 SEQ ID NO 123 
                 SEQ ID NO 171 
                 SEQ ID NO 195 
               
               
                 Thermoascus aurantiacus 
                 SEQ ID NO 124 
                 SEQ ID NO 172 
                 SEQ ID NO 196 
               
               
                 Thermoascus aurantiacus 
                 SEQ ID NO 125 
                 SEQ ID NO 173 
                 SEQ ID NO 197 
               
               
                 Thermoascus aurantiacus 
                 SEQ ID NO 126 
                 SEQ ID NO 174 
                 SEQ ID NO 198 
               
               
                 Thermoascus aurantiacus 
                 SEQ ID NO 250 
                 SEQ ID NO 251 
               
               
                   
               
            
           
         
       
     
     DETAILED DESCRIPTION OF THE INVENTION 
     The invention is related one or more polypeptides having superoxide dismutase activity in animal feed wherein the superoxide dismutase is of fungal origin. 
     Definitions 
     Animal: The term “animal” refers to any animal except humans. Examples of animals are monogastric animals, including but not limited to pigs or swine (including, but not limited to, piglets, growing pigs, and sows); poultry such as turkeys, ducks, quail, guinea fowl, geese, pigeons (including squabs) and chicken (including but not limited to broiler chickens (referred to herein as broiles), chicks, layer hens (referred to herein as layers)); pets such as cats and dogs; horses (including but not limited to hotbloods, coldbloods and warm bloods) crustaceans (including but not limited to shrimps and prawns) and fish (including but not limited to amberjack, arapaima, barb, bass, bluefish, bocachico, bream, bullhead, cachama, carp, catfish, catla, chanos, char, cichlid, cobia, cod, crappie, dorada, drum, eel, goby, goldfish, gourami, grouper, guapote, halibut, java, labeo, lai, loach, mackerel, milkfish, mojarra, mudfish, mullet, paco, pearlspot, pejerrey, perch, pike, pompano, roach, salmon, sampa, sauger, sea bass, seabream, shiner, sleeper, snakehead, snapper, snook, sole, spinefoot, sturgeon, sunfish, sweetfish, tench, terror, tilapia, trout, tuna, turbot, vendace, walleye and whitefish). 
     Animal feed: The term “animal feed” refers to any compound, preparation, or mixture suitable for, or intended for intake by an animal. Animal feed for a monogastric animal typically comprises concentrates as well as vitamins, minerals, enzymes, direct fed microbial, amino acids and/or other feed ingredients (such as in a premix) whereas animal feed for ruminants generally comprises forage (including roughage and silage) and may further comprise concentrates as well as vitamins, minerals, enzymes direct fed microbial, amino acid and/or other feed ingredients (such as in a premix). 
     Concentrates: The term “concentrates” means feed with high protein and energy concentrations, such as fish meal, molasses, oligosaccharides, sorghum, seeds and grains (either whole or prepared by crushing, milling, etc. from e.g. corn, oats, rye, barley, wheat), oilseed press cake (e.g. from cottonseed, safflower, sunflower, soybean (such as soybean meal), rapeseed/canola, peanut or groundnut), palm kernel cake, yeast derived material and distillers grains (such as wet distillers grains (WDS) and dried distillers grains with solubles (DDGS)). 
     Feed efficiency: The term “feed efficiency” means the amount of weight gain per unit of feed when the animal is fed ad-libitum or a specified amount of food during a period of time. By “increased feed efficiency” it is meant that the use of a feed additive composition according the present invention in feed results in an increased weight gain per unit of feed intake compared with an animal fed without said feed additive composition being present. 
     Feed Conversion Ratio (FCR): FCR is a measure of an animal&#39;s efficiency in converting feed mass into increases of the desired output. Animals raised for meat such as swine, poultry and fish the output is the mass gained by the animal. Specifically, FCR is calculated as feed intake divided by weight gain, all over a specified period. Improvement in FCR means reduction of the FCR value. An FCR improvement of 2% means that the FCR was reduced by 2%. 
     Feed Premix: The incorporation of the composition of feed additives as exemplified herein above to animal feeds, for example poultry feeds, is in practice carried out using a concentrate or a premix. A premix designates a preferably uniform mixture of one or more microingredients with diluent and/or carrier. Premixes are used to facilitate uniform dispersion of micro-ingredients in a larger mix. A premix according to the invention can be added to feed ingredients or to the drinking water as solids (for example as water soluble powder) or liquids. 
     European Production Efficiency Factor (EPEF): The European Production Efficiency Factor is a way of comparing the performance of animals. This single-figure facilitates comparison of performance within and among farms and can be used to assess environmental, climatic and animal management variables. The EPEF is calculated as [(liveability (%)×Liveweight (kg))/(Age at depletion (days)×FCR)]×100, wherein livability is the percentage of animals alive at slaughter, Liveweight is the average weight of the animals at slaughter, age of depletion is the age of the animals at slaughter and FCR is the feed conversion ratio at slaughter. 
     Forage: The term “forage” as defined herein also includes roughage. Forage is fresh plant material such as hay and silage from forage plants, grass and other forage plants, seaweed, sprouted grains and legumes, or any combination thereof. Examples of forage plants are Alfalfa (lucerne), birdsfoot trefoil,  brassica  (e.g. kale, rapeseed (canola), rutabaga (swede), turnip), clover (e.g. alsike clover, red clover, subterranean clover, white clover), grass (e.g. 
     Bermuda grass, brome, false oat grass, fescue, heath grass, meadow grasses, orchard grass, ryegrass, Timothy-grass), corn (maize), millet, barley, oats, rye, sorghum, soybeans and wheat and vegetables such as beets. Forage further includes crop residues from grain production (such as corn stover; straw from wheat, barley, oat, rye and other grains); residues from vegetables like beet tops; residues from oilseed production like stems and leaves form soy beans, rapeseed and other legumes; and fractions from the refining of grains for animal or human consumption or from fuel production or other industries. 
     Fragment: The term “fragment” means a polypeptide or a catalytic domain having one or more (e.g., several) amino acids absent from the amino and/or carboxyl terminus of a mature polypeptide or domain; wherein the fragment has SOD activity.several) amino acids absent from the amino and/or carboxyl terminus of a mature polypeptide or domain; wherein the fragment has SOD activity. 
     In one aspect, a fragment of a GH24 SOD (such as one of SEQ ID NO: 63 to 71) comprises at least 230 amino acids, such as at least 235 amino acids, at least 240 amino acids, or at least 245 amino acids and has SOD activity. In another aspect, a fragment of a GH24 SOD (such as one of SEQ ID NO: 63 to 71) comprises at least 90% of the length of the mature polypeptide, such as at least 92%, at least 94%, at least 96%, at least 98% or at least 99% of the length of the mature polypeptide and has SOD activity. 
     In one aspect, a fragment of a GH25 SOD (such as one of SEQ ID NO: 1 to 72) comprises at least 180 amino acids, such as at least 185 amino acids, at least 190 amino acids, at least 195 amino acids, at least 200 amino acids, at least 205 amino acids or at least 210 amino acids and has SOD activity. In another aspect, a fragment of a GH25 SOD (such as one of SEQ ID NO: 1 to 72) comprises at least 90% of the length of the mature polypeptide, such as at least 92%, at least 94%, at least 96%, at least 98% or at least 99% of the length of the mature polypeptide and has SOD activity. 
     Fungal origin: The term “fungal origin is intended to mean, in reference to a superoxide dismutase, that the source of the enzyme in a fungus. A fungus is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as a kingdom, fungi. Currently, seven phyla are proposed: Microsporidia, Chytridiomycota, Blastocladiomycota, Neocallimastigomycota, Glomeromycota, Ascomycota, and Basidiomycota. Suitable examples include, without limitation,  Trichoderma reesei, Aspergillus versicolor, Aspergillus deflectus, Aspergillus egyptiacus, Westerdykella  sp. AS85-2,  Aspergillus  sp. XZ2669 , Preussia terricola, Kionochaeta  sp.,  Metapochonia bulbillosa, Xylomelasma  sp. XZ0718 , Preussia flanaganii, Cladobotryum  sp.,  Westerdykella  sp-46156,  Trichoderma hamatum, Mycothermus thermophilus, Cephalotrichiella penicillate, Chaetomium megalocarpum, Chaetomium thermophilum  var.  thermophilum, Humicola hyalothermophila, Subramaniula anamorphosa, Sphingobacterium  sp. T2,  Trichoderma rossicum, Trichoderma lixii, Trichoderma  sp-54723,  Aspergillus niveus, Aspergillus templicola, Pochonia chlamydosporia  var.  spinulospora, Trichoderma  sp-44174,  Trichoderma rossicum, Trichoderma  sp-54723,  Trichoderma  sp-44174 , Metapochonia suchlasporia, Metarhizium marquandii, Diaporthe nobilis, Tolypocladium  sp. XZ2627,  Aspergillus japonicus, Metarhizium  sp. XZ2431,  Armillaria ostoyae, Trichoderma spirale, Aspergillus elegans, Trichoderma sinuosum, Trichoderma virens, Trichoderma harzianum, Fusicolla acetilerea, Plectosphaerella  sp. 1-29 , Mariannaea punicea, Penicillium oxalicum, Colletotrichum  sp-71086,  Aspergillus  sp.  nov . XZ3202,  Trichoderma parapiluliferum, Aspergillus  sp.  nov . XZ3202,  Mucor  sp. XZ2651,  Rhizomucor miehei, Mucor  sp. XZ2651, Amphisphaeriaceae-sp 43674,  Humicola fuscoatra  and  Valsaria rubricosa.    
     Heat Stress: Heat stress occurs when an animal&#39;s heat load is greater than its capacity to lose heat. Pigs andother animals likely experience headaches, irritability and lethargy when they are too hot and have insufficient water. One or more of the following are typically observed with heat stress: increased breathing rate and sweating, increased water intake, decreased feed intake. 
     Isolated: The term “isolated” means a substance in a form or environment that does not occur in nature. Non-limiting examples of isolated substances include (1) any non-naturally occurring substance, (2) any substance including, but not limited to, any enzyme, variant, nucleic acid, protein, peptide or cofactor, that is at least partially removed from one or more or all of the naturally occurring constituents with which it is associated in nature; (3) any substance modified by the hand of man relative to that substance found in nature; or (4) any substance modified by increasing the amount of the substance relative to other components with which it is naturally associated (e.g., multiple copies of a gene encoding the substance; use of a stronger promoter than the promoter naturally associated with the gene encoding the substance). An isolated substance may be present in a fermentation broth sample. 
     Mature polypeptide: The term “mature polypeptide” means a polypeptide in its final form following translation and any post-translational modifications, such as N-terminal processing, C-terminal truncation, glycosylation, phosphorylation, etc. 
     Physical determination of the mature N terminus of SODs was done with Mass Spectrometry. Samples were diluted to 0.1 mg/ml in water. If they were to be deglycosylated before analysis, the samples were suspended in 50 mM Ammonium acetate buffer pH 5.5. The samples are then placed in an Ultimate 3000 UHPLC system (Thermo Scientific) at 8 degrees C. and run over an Advance Bio-RP desalting column (Agilent) The solvents used were A: LC/MS grade water with 0.1% formic acid, solvent: B 95% acetonitrile with 0.1% formic acid. The gradient was 5-80% B over 5 minutes. Post column the protein eluent was analyzed in a Bruker Maxis II mass spectrometer (Bremen Germany) and the resulting trace was analyzed by the supplied Bruker data analysis software. The deconvoluted spectrum was then compared to the calculated molecular weight with the expected N and C terminals using GPMAW (General Protein/Mass Analysis for Windows) software version 12.20. If the values match within 1 Dalton, a match was concluded. 
     Nutritional Stress: In pigs, poultry and other animals, symptoms of nutritional stress include impaired growth, immune suppression, reduced gut health, reduced gut integrity, shift in gut microflora and vomiting. In poultry, further symptoms include decreased egg production, decreased hatchability, gizzaed lesions, increased suspectibility to necrotic enteritis. 
     Obtained or obtainable from: The term “obtained or obtainable from” means that the polypeptide may be found in an organism from a specific taxonomic rank. In one embodiment, the polypeptide is obtained or obtainable from the kingdom Fungi, wherein the term kingdom is the taxonomic rank. In a preferred embodiment, the polypeptide is obtained or obtainable from the phylum Ascomycota, wherein the term phylum is the taxonomic rank. In another preferred embodiment, the polypeptide is obtained or obtainable from the subphylum Pezizomycotina, wherein the term subphylum is the taxonomic rank. In another preferred embodiment, the polypeptide is obtained or obtainable from the class Eurotiomycetes, wherein the term class is the taxonomic rank. 
     If the taxonomic rank of a polypeptide is not known, it can easily be determined by a person skilled in the art by performing a BLASTP search of the polypeptide (using e.g. the National Center for Biotechnology Information (NCIB) website http://www.ncbi.nlm.nih.gov/) and comparing it to the closest homologues. The skilled person can also compare the sequence to those of the application as filed. An unknown polypeptide which is a fragment of a known polypeptide is considered to be of the same taxonomic species. An unknown natural polypeptide or artificial variant which comprises a substitution, deletion and/or insertion in up to 10 positions is considered to be from the same taxonomic species as the known polypeptide. 
     Oxidative Stress: The term “oxidative stress” is intended to mean an imbalance between oxidants and reductants (antioxidants) at the cellular or individual level. Oxidative damage is one result of such an imbalance and includes oxidative modification of cellular macromolecules, cell death by apoptosis or necrosis, as well as structural tissue damage by means of reactive oxygen and nitrogen species (ROS, RNS). 
     Roughage: The term “roughage” means dry plant material with high levels of fiber, such as fiber, bran, husks from seeds and grains and crop residues (such as stover, copra, straw, chaff, sugar beet waste). 
     Secreted Enzyme: A secreted enzyme is an exoenzyme, or extracellular enzyme, in that is an enzyme that is secreted by a cell and functions outside that cell. 
     Sequence identity: The relatedness between two amino acid sequences or between two nucleotide sequences is described by the parameter “sequence identity”. 
     For purposes of the present invention, the sequence identity between two amino acid sequences is determined using the Needleman-Wunsch algorithm (Needleman and Wunsch, 1970, J. Mol. Biol. 48: 443-453) as implemented in the Needle program of the EMBOSS package (EMBOSS: The European Molecular Biology Open Software Suite, Rice et al., 2000, Trends Genet. 16: 276-277), preferably version 5.0.0 or later. The parameters used are gap open penalty of 10, gap extension penalty of 0.5, and the EBLOSUM62 (EMBOSS version of BLOSUM62) substitution matrix. The output of Needle labeled “longest identity” (obtained using the −nobrief option) is used as the percent identity and is calculated as follows: 
       (Identical Residues×100)/(Length of Alignment−Total Number of Gaps in Alignment)
 
     Substantially pure polypeptide: The term “substantially pure polypeptide” means a preparation that contains at most 10%, at most 8%, at most 6%, at most 5%, at most 4%, at most 3%, at most 2%, at most 1%, and at most 0.5% by weight of other polypeptide material with which it is natively or recombinantly associated. Preferably, the polypeptide is at least 92% pure, e.g., at least 94% pure, at least 95% pure, at least 96% pure, at least 97% pure, at least 98% pure, at least 99%, at least 99.5% pure, and 100% pure by weight of the total polypeptide material present in the preparation. The polypeptides of the present invention are preferably in a substantially pure form. This can be accomplished, for example, by preparing the polypeptide by well known recombinant methods or by classical purification methods. 
     Tm: The term Tm, as used in the Examples refers to the temperature at which 50% of the protein molecules are unfolded and 50% of the protein molecules are folded. 
     Variant: The term “variant” means a polypeptide having SOD activity comprising an alteration, i.e., a substitution, insertion, and/or deletion, of one or more (several) amino acid residues at one or more (e.g., several) positions. A substitution means replacement of the amino acid occupying a position with a different amino acid; a deletion means removal of the amino acid occupying a position; and an insertion means adding 1, 2, or 3 amino acids adjacent to and immediately following the amino acid occupying the position. 
     In one aspect, a SOD variant may comprise from 1 to 10 alterations, i.e. 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 alterations and have at least 20%, e.g., at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 95%, or at least 100% of the SOD activity of the parent SOD, such as SEQ ID NO: 1 to 5. 
     Nutrient: The term “nutrient” in the present invention means components or elements contained in dietary feed for an animal, including water-soluble ingredients, fat-soluble ingredients and others. The example of water-soluble ingredients includes but is not limited to carbohydrates such as saccharides including glucose, fructose, galactose and starch; minerals such as calcium, magnesium, zinc, phosphorus, potassium, sodium and sulfur; nitrogen source such as amino acids and proteins, vitamins such as vitamin B1, vitamin B2, vitamin B3, vitamin B6, folic acid, vitamin B12, biotin and phatothenic acid. The example of the fat-soluble ingredients includes but is not limited to fats such as fat acids including saturated fatty acids (SFA); mono-unsaturated fatty acids (MUFA) and poly-unsaturated fatty acids (PUFA), fibre, vitamins such as vitamin A, vitamin E and vitamin K. 
     Super Oxide Dismutases 
     The invention is directed at least in part to novel polypeptides having superoxide dismutase activity. 
     One aspect of the invention is directed to an isolated polypeptide having superoxide dismutase activity selected from the group consisting of:
         a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 1;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 2;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 3;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 4;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 9;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 10;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 11;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 12;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 13;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 14;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 15;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 16;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 17;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 19;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 20;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 21;   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 22;   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 23;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 24;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 25;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 26;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 27;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 28;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 29;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 30;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 31;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 32;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 33;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 34;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 36;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 38;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 39;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 42;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 43;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 44;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 45;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 46;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 47; and   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 48;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:199;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:200;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 201;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:202;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:203;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:204;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 205;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:206;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:207;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:208;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:209;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:232;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:233;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:234;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:235;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:236; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:237.       

     One aspect of the invention is directed to an isolated polypeptide having superoxide dismutase activity comprising an amino acid sequence selected from the group consisting of:
         a. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 1;   b. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 2;   c. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 3;   d. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 4;   e. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 9;   f. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 10;   g. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 11;   h. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 12;   i. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 13;   j. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 14;   k. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 15;   l. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 16;   m. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 17;   n. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 19;   o. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 20;   p. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 21;   q. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 22;   r. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 23;   s. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 24;   t. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100 sequence identity to the amino acid sequence of SEQ ID NO: 25;   u. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 26;   v. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 27;   w. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 28;   x. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 29;   y. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 30;   z. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 31;   aa. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 32;   bb. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 33;   cc. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 34;   dd. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 36;   ee. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 38;   ff. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 39;   gg. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;   hh. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;   ii. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 42;   jj. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 43;   kk. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 44;   ll. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 45;   mm. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 46;   nn. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 47; and   oo. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 48;   pp. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:199;   qq. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:200;   rr. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO 201;   ss. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:202;   tt. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:203;   uu. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:204;   vv. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 205;   ww. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:206;   xx. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:207;   yy. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:208;   zz. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:209;   aaa. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:232;   bbb. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:233;   ccc. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:234;   ddd. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:235;   eee. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:236; and   fff. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:237.       

     On aspect of the invention is directed to an isolated polypeptide having superoxide dismutase activity selected from the group consisting of
         a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 83;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 84;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 85;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 86;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 49;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 50;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 51;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 52;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 53;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 54;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 55;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 56;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 18;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 57;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 58;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 59,   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 60,   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 61;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 62;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 63;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 64;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 65;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 66;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 67;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 68;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 69;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 70;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 71;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 35;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 37;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 72;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 73;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 74;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 75;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 76;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 77;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 78;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 79;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 80;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 81;   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 82;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 210;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 211;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 212;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 213;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 214;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 215;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 216;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 217;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 218;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 219;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 220;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 238;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 239;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 240;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 241;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 242; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 243.       

     One aspect of the invention is directed to an isolated polypeptide of having superoxide dismutase activity selected from the group consisting of
         a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 307 of SEQ ID NO 83;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 206 of SEQ ID NO 84;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 17 to 154 of SEQ ID NO 85;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 188 of SEQ ID NO 86;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 247 of SEQ ID NO 49;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 184 of SEQ ID NO 50;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 249 of SEQ ID NO 51;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 178 of SEQ ID NO 52;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 248 of SEQ ID NO 53;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 186 of SEQ ID NO 54;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 274 of SEQ ID NO 55;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 26 to 257 of SEQ ID NO 56;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 23 to 261 of SEQ ID NO 18;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 247 of SEQ ID NO 57;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 269 of SEQ ID NO 58;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 151 of SEQ ID NO 59,   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 33 to 228 of SEQ ID NO 60,   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 37 to 233 of SEQ ID NO 61;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 33 to 227 of SEQ ID NO 62;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 34 to 230 of SEQ ID NO 63;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 37 to 233 of SEQ ID NO 64;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 25 to 227 of SEQ ID NO 65;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 211 of SEQ ID NO 66;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 218 of SEQ ID NO 67;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 218 of SEQ ID NO 68;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 17 to 182 of SEQ ID NO 69;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 185 of SEQ ID NO 70;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 185 of SEQ ID NO 71;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 280 of SEQ ID NO 35;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 304 of SEQ ID NO 37;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 310 of SEQ ID NO 72;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 303 of SEQ ID NO 73;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 186 of SEQ ID NO 74;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 186 of SEQ ID NO 75;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 209 of SEQ ID NO 76;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 209 of SEQ ID NO 77;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 22 to 183 of SEQ ID NO 78;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 193 of SEQ ID NO 79;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 177 of SEQ ID NO 80;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 280 of SEQ ID NO 81;   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 23 to 215 of SEQ ID NO 82;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 181 of SEQ ID NO 210;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 181 of SEQ ID NO 211;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 182 of SEQ ID NO 212;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 154 of SEQ ID NO 213;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 154 of SEQ ID NO 214;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 154 of SEQ ID NO 215;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 150 of SEQ ID NO 216;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 247 of SEQ ID NO 217;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 154 of SEQ ID NO 218;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 316 of SEQ ID NO 219;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 193 of SEQ ID NO 220;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 186 of SEQ ID NO 238;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 14 to 164 of SEQ ID NO 239;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 184 of SEQ ID NO 240;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 242 of SEQ ID NO 241;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 261 of SEQ ID NO 242; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 258 of SEQ ID NO 243.       

     One aspect of the invention is directed to an isolated polypeptide of having superoxide dismutase activity selected from the group consisting of
         a. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 5;   b. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 87;   c. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 88;   d. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 89;   e. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 90;   f. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 91;   g. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 92;   h. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 93;   i. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 94;   j. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 95;   k. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 96;   l. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 97;   m. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 98;   n. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 99;   o. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 100;   p. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 101;   q. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 102;   r. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 127;   s. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 128;   t. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 129;   u. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 130;   v. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 131;   w. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 132;   x. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 133;   y. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 134;   z. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 135;   aa. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 136;   bb. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 137;   cc. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 138;   dd. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 139;   ee. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 140;   ff. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 141;   gg. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 142;   hh. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 143;   ii. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 144;   jj. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 145;   kk. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 146;   ll. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 147;   mm. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 148;   nn. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 149;   oo. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 150;   pp. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 221;   qq. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 222;   rr. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 223;   ss. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 224;   tt. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 225;   uu. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 226;   vv. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 227;   ww. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of 228;   xx. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 229;   yy. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 230;   zz. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 231;   aaa. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 244;   bbb. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO SEQ ID NO 245;   ccc. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 246;   ddd. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 247;   eee. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 248; and   fff. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 249.       

     Sequences of Superoxide Dismutases of the Animal Feed 
     Superoxide dismutase (SOD, EC 1.15.1.1) is an enzyme that alternately catalyzes the dismutation (or partitioning) of the superoxide (O 2   − ) radical into either ordinary molecular oxygen (O 2 ) or hydrogen peroxide (H 2 O 2 ). 
     The invention is furthermore directed to an animal feed or animal feed additive comprising polypeptides of fungal origin having superoxide dismutase activity. 
     More particularly, according to the invention, the animal feed or animal feed additive comprising polypeptides of fungal origin having superoxide dismutase activity may comprise a polypeptide of fungal origin having superoxide dismutase activity selected from the group consisting of:
         a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 1;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 2;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 3;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 4;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 9;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 10;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 11;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 12;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 13;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 14;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 15;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 16;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 17;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 19;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 20;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 21;   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 22;   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 23;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 24;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 25;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 26;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 27;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 28;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 29;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 30;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 31;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 32;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 33;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 34;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 36;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 38;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 39;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 42;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 43;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 44;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 45;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 46;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 47; and   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 48;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:199;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:200;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 201;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:202;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:203;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:204;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 205;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:206;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:207;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:208;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:209;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:232;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:233;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:234;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:235;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:236; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:237.       

     Alternatively defined, the polypeptide having superoxide dismutase activity may comprise an amino acid sequence selected from the group consisting of:
         a. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 1;   b. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 2;   c. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 3;   d. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 4;   e. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 9;   f. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 10;   g. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 11;   h. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 12;   i. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 13;   j. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 14;   k. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 15;   l. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 16;   m. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 17;   n. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 19;   o. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 20;   p. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 21;   q. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 22;   r. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 23;   s. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 24;   t. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100 sequence identity to the amino acid sequence of SEQ ID NO: 25;   u. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 26;   v. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 27;   w. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 28;   x. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 29;   y. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 30;   z. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 31;   aa. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 32;   bb. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 33;   cc. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 34;   dd. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 36;   ee. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 38;   ff. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 39;   gg. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;   hh. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;   ii. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 42;   jj. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 43;   kk. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 44;   ll. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 45;   mm. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 46;   nn. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 47; and   oo. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 48;   pp. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:199;   qq. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:200;   rr. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO 201;   ss. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:202;   tt. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:203;   uu. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:204;   vv. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 205;   ww. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:206;   xx. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:207;   yy. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:208;   zz. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:209;   aaa. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:232;   bbb. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:233;   ccc. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:234;   ddd. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:235;   eee. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:236; and   fff. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:237.       

     The polypeptide of fungal origin having superoxide dismutase activity may be selected from the group consisting
         a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 83;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 84;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 85;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 86;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 49;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 50;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 51;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 52;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 53;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 54;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 55;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 56;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 18;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 57;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 58;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 59,   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 60,   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 61;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 62;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 63;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 64;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 65;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 66;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 67;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 68;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 69;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 70;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 71;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 35;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 37;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 72;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 73;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 74;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 75;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 76;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 77;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 78;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 79;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 80;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 81;   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 82;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 210;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 211;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 212;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 213;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 214;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 215;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 216;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 217;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 218;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 219;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 220;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 238;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 239;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 240;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 241;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 242; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 243.       

     The polypeptide of fungal origin having superoxide dismutase activity may be selected from the group consisting of
         a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 307 of SEQ ID NO 83;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 206 of SEQ ID NO 84;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 17 to 154 of SEQ ID NO 85;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 188 of SEQ ID NO 86;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 247 of SEQ ID NO 49;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 184 of SEQ ID NO 50;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 249 of SEQ ID NO 51;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 178 of SEQ ID NO 52;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 248 of SEQ ID NO 53;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 186 of SEQ ID NO 54;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 274 of SEQ ID NO 55;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 26 to 257 of SEQ ID NO 56;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 23 to 261 of SEQ ID NO 18;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 247 of SEQ ID NO 57;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 269 of SEQ ID NO 58;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 151 of SEQ ID NO 59,   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 33 to 228 of SEQ ID NO 60,   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 37 to 233 of SEQ ID NO 61;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 33 to 227 of SEQ ID NO 62;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 34 to 230 of SEQ ID NO 63;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 233 of SEQ ID NO 64;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 25 to 227 of SEQ ID NO 65;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 211 of SEQ ID NO 66;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 218 of SEQ ID NO 67;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 218 of SEQ ID NO 68;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 17 to 182 of SEQ ID NO 69;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 185 of SEQ ID NO 70;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 185 of SEQ ID NO 71;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 280 of SEQ ID NO 35;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 304 of SEQ ID NO 37;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 310 of SEQ ID NO 72;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 303 of SEQ ID NO 73;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 186 of SEQ ID NO 74;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 186 of SEQ ID NO 75;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 209 of SEQ ID NO 76;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 209 of SEQ ID NO 77;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 22 to 183 of SEQ ID NO 78;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 193 of SEQ ID NO 79;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 177 of SEQ ID NO 80;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 280 of SEQ ID NO 81;   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 23 to 215 of SEQ ID NO 82;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 181 of SEQ ID NO 210;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 181 of SEQ ID NO 211;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 182 of SEQ ID NO 212;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 154 of SEQ ID NO 213;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 154 of SEQ ID NO 214;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 154 of SEQ ID NO 215;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 150 of SEQ ID NO 216;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 247 of SEQ ID NO 217;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 154 of SEQ ID NO 218;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 316 of SEQ ID NO 219;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 193 of SEQ ID NO 220;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 186 of SEQ ID NO 238;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 14 to 164 of SEQ ID NO 239;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 184 of SEQ ID NO 240;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 242 of SEQ ID NO 241;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 261 of SEQ ID NO 242; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 258 of SEQ ID NO 243.       

     The polypeptide of fungal origin having superoxide dismutase activity may be selected from the group consisting
         a. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 5;   b. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 87;   c. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 88;   d. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 89;   e. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 90;   f. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 91;   g. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 92;   h. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 93;   i. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 94;   j. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 95;   k. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 96;   l. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 97;   m. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 98;   n. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 99;   o. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 100;   p. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 101;   q. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 102;   r. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 127;   s. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 128;   t. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 129;   u. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 130;   v. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 131;   w. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 132;   x. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 133;   y. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 134;   z. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 135;   aa. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 136;   bb. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 137;   cc. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 138;   dd. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 139;   ee. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 140;   ff. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 141;   gg. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 142;   hh. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 143;   ii. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 144;   jj. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 145;   kk. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 146;   ll. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 147;   mm. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 148;   nn. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 149;   oo. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 150;   pp. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 221;   qq. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 222;   rr. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 223;   ss. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 224;   tt. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 225;   uu. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 226;   vv. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 227;   ww. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of 228;   xx. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 229;   yy. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 230;   zz. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 231;   aaa. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 244;   bbb. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO SEQ ID NO 245;   ccc. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 246;   ddd. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 247;   eee. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 248; and   fff. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 249.       

     As the SODs defined above are novel enzymes, the invention further relates to an isolated polypeptide as defined herein having superoxide dismutase activity. 
     The amino acid changes in the sequences disclosed above may be of a minor nature, that is conservative amino acid substitutions or insertions that do not significantly affect the folding and/or activity of the protein; small deletions, typically of 1-30 amino acids; small amino- or carboxyl-terminal extensions, such as an amino-terminal methionine residue; a small linker peptide of up to 20-25 residues; or a small extension that facilitates purification by changing net charge or another function, such as a poly-histidine tract, an antigenic epitope or a binding domain. 
     Examples of conservative substitutions are within the groups of basic amino acids (arginine, lysine and histidine), acidic amino acids (glutamic acid and aspartic acid), polar amino acids (glutamine and asparagine), hydrophobic amino acids (leucine, isoleucine and valine), aromatic amino acids (phenylalanine, tryptophan and tyrosine), and small amino acids (glycine, alanine, serine, threonine and methionine). Amino acid substitutions that do not generally alter specific activity are known in the art and are described, for example, by H. Neurath and R. L. Hill, 1979 , In, The Proteins , Academic Press, New York. Common substitutions are Ala/Ser, Val/Ile, Asp/Glu, Thr/Ser, Ala/Gly, Ala/Thr, Ser/Asn, Ala/Val, Ser/Gly, Tyr/Phe, Ala/Pro, Lys/Arg, Asp/Asn, Leu/Ile, Leu/Val, Ala/Glu, and Asp/Gly. 
     Essential amino acids in the polypeptide can be identified according to procedures known in the art, such as site-directed mutagenesis or alanine-scanning mutagenesis (Cunningham and Wells, 1989 , Science  244: 1081-1085). In the latter technique, single alanine mutations are introduced at every residue in the molecule, and the resultant mutant molecules are tested for SOD activity to identify amino acid residues that are critical to the activity of the molecule. See also, Hilton et al., 1996 , J. Biol. Chem.  271: 4699-4708. The active site of the enzyme or other biological interaction can also be determined by physical analysis of structure, as determined by such techniques as nuclear magnetic resonance, crystallography, electron diffraction, or photoaffinity labelling, in conjunction with mutation of putative contact site amino acids. See, for example, de Vos et al., 1992 , Science  255: 306-312; Smith et al., 1992 , J. Mol. Biol.  224: 899-904; Wlodaver et al., 1992 , FEBS Lett.  309: 59-64. The identity of essential amino acids can also be inferred from an alignment with a related polypeptide. 
     Sources of Superoxide Dismutases 
     The polypeptide of the invention having superoxide dismutase activity is of fungal origin. 
     As shown from the Examples, the superoxide dismutase of the invention may be obtainable, may be obtained, may be derived from a superoxide dismutase obtainable from a fungus selected from the group consisting of  Trichoderma reesei, Aspergillus versicolor, Aspergillus deflectus, Aspergillus egyptiacus, Westerdykella  sp. AS85-2,  Aspergillus  sp. XZ2669 , Preussia terricola, Kionochaeta  sp.,  Metapochonia bulbillosa, Xylomelasma  sp. XZ0718 , Preussia flanaganii, Cladobotryum  sp.,  Westerdykella  sp-46156,  Trichoderma hamatum, Mycothermus thermophilus, Cephalotrichiella penicillate, Chaetomium megalocarpum, Chaetomium thermophilum  var.  thermophilum, Humicola hyalothermophila, Subramaniula anamorphosa, Sphingobacterium  sp. T2,  Trichoderma  rossicum,  Trichoderma lixii, Trichoderma  sp-54723,  Aspergillus niveus, Aspergillus templicola, Pochonia chlamydosporia  var.  spinulospora, Trichoderma  sp-44174,  Trichoderma  rossicum,  Trichoderma  sp-54723,  Trichoderma  sp-44174 , Metapochonia suchlasporia, Metarhizium marquandii, Diaporthe nobilis, Tolypocladium  sp. XZ2627,  Aspergillus japonicus, Metarhizium  sp. XZ2431,  Armillaria ostoyae, Trichoderma spirale, Aspergillus elegans, Trichoderma sinuosum, Trichoderma virens, Trichoderma harzianum, Fusicolla acetilerea, Plectosphaerella  sp. 1-29 , Mariannaea punicea, Penicillium oxalicum, Colletotrichum  sp-71086,  Aspergillus  sp.  nov . XZ3202,  Trichoderma parapiluliferum, Aspergillus  sp.  nov . XZ3202,  Mucor  sp. XZ2651,  Rhizomucor miehei, Mucor  sp. XZ2651, Amphisphaeriaceae-sp 43674,  Humicola fuscoatra  and  Valsaria rubricosa.    
     The polypeptide having superoxide dismutase activity may be selected from the group consisting of: 
     a. a polypeptide  Trichoderma reesei  from having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 1;
 
b. a polypeptide from  Aspergillus versicolor  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 2;
 
c. a polypeptide from  Aspergillus deflectus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 3;
 
d. a polypeptide from  Aspergillus egyptiacus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 4;
 
e. a polypeptide from  Westerdykella  sp. AS85-2 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 9;
 
f. a polypeptide from  Aspergillus  sp. XZ2669 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 10;
 
g. a polypeptide from  Preussia terricola  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 11;
 
h. a polypeptide from  Kionochaeta  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 12;
 
i. a polypeptide from  Kionochaeta  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 13;
 
j. a polypeptide from  Metapochonia bulbillosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 14;
 
k. a polypeptide from  Xylomelasma  sp. XZ0718 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 15;
 
l. a polypeptide from  Preussia flanaganii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 16;
 
m. a polypeptide from  Cladobotryum  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 17;
 
n. a polypeptide from  Westerdykella  sp-46156 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 19;
 
o. a polypeptide from  Trichoderma hamatum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 20;
 
p. a polypeptide from  Mycothermus thermophilus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 21;
 
q. a polypeptide from  Cephalotrichiella penicillata  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 22;
 
r. a polypeptide from  Chaetomium megalocarpum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 23;
 
s. a polypeptide from  Chaetomium thermophilum  var.  thermophilum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 24;
 
t. a polypeptide from  Humicola hyalothermophila  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 25;
 
u. a polypeptide from  Subramaniula anamorphosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 26;
 
v. a polypeptide from  Sphingobacterium  sp. T2 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 27;
 
w. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 28;
 
x. a polypeptide from  Trichoderma lixii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 29;
 
y. a polypeptide from  Trichoderma  sp-54723 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 30;
 
z. a polypeptide from  Aspergillus niveus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 31;
 
aa. a polypeptide from  Aspergillus templicola  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 32;
 
bb. a polypeptide from  Pochonia chlamydosporia  var.  spinulospora  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 33;
 
cc. a polypeptide from  Trichoderma  sp-44174 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 34;
 
dd. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 36;
 
ee. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 38;
 
ff. a polypeptide from  Trichoderma  sp-44174 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 39;
 
gg. a polypeptide from  Metapochonia suchlasporia  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;
 
hh. a polypeptide from  Metarhizium marquandii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;
 
ii. a polypeptide from  Diaporthe nobilis  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 42;
 
jj. a polypeptide from  Tolypocladium  sp. XZ2627 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 43;
 
kk. a polypeptide from  Aspergillus japonicus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 44;
 
ll. a polypeptide from  Metarhizium  sp. XZ2431 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 45;
 
mm. a polypeptide from  Armillaria ostoyae  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 46;
 
nn. a polypeptide from  Trichoderma spirale  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 47; and
 
oo. a polypeptide from  Aspergillus elegans  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 48;
 
pp. a polypeptide from  Trichoderma sinuosum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:199;
 
qq. a polypeptide from  Trichoderma virens  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:200;
 
rr. a polypeptide from  Trichoderma harzianum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 201;
 
ss. a polypeptide from  Fusicolla acetilerea  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:202;
 
tt. a polypeptide from  Plectosphaerella  sp. 1-29 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:203;
 
uu. a polypeptide  Mariannaea punicea  from having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:204;
 
vv. a polypeptide from  Penicillium oxalicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 205;
 
ww. a polypeptide from  Colletotrichum  sp-71086 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:206;
 
xx. a polypeptide from  Aspergillus  sp.  nov . XZ3202 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:207;
 
yy. a polypeptide from  Trichoderma parapiluliferum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:208;
 
zz. a polypeptide from  Aspergillus  sp.  nov . XZ3202 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:209;
 
aaa. a polypeptide from  Mucor  sp. XZ2651 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:232;
 
bbb. a polypeptide from  Rhizomucor miehei  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:233;
 
ccc. a polypeptide from  Mucor  sp. XZ2651 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:234;
 
ddd. a polypeptide from Amphisphaeriaceae -sp 43674 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:235;
 
eee. a polypeptide from  Humicola fuscoatra  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:236; and
 
fff. a polypeptide from  Valsaria rubricosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:237.
 
     The polypeptide having superoxide dismutase activity may be selected from the group consisting
         a. a polypeptide from  Trichoderma reesei  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 83;   b. a polypeptide from  Aspergillus versicolor  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 84;   c. a polypeptide from  Aspergillus deflectus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 85;   d. a polypeptide from  Aspergillus egyptiacus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 86;   e. a polypeptide from  Westerdykella  sp. AS85-2 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 49;   f. a polypeptide from  Aspergillus  sp. XZ2669 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 50;   g. a polypeptide from  Preussia terricola  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 51;   h. a polypeptide from  Kionochaeta  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 52;   i. a polypeptide from  Kionochaeta  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 53;   j. a polypeptide from  Metapochonia bulbillosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 54;   k. a polypeptide from  Xylomelasma  sp. XZ0718 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 55;   l. a polypeptide from  Preussia flanaganii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 56;   m. a polypeptide from  Cladobotryum  sp having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 18;   n. a polypeptide from  Westerdykella  sp-46156 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 57;   o. a polypeptide from  Trichoderma hamatum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 58;   p. a polypeptide from  Mycothermus thermophilus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 59,   q. a polypeptide from  Cephalotrichiella penicillata  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 60,   r. a polypeptide from  Chaetomium megalocarpum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 61;   s. a polypeptide from  Chaetomium thermophilum  var.  thermophilum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 62;   t. a polypeptide from  Humicola hyalothermophila  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 63;   u. a polypeptide from  Subramaniula anamorphosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 64;   v. a polypeptide from  Sphingobacterium  sp. T2 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 65;   w. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 66;   x. a polypeptide from  Trichoderma lixii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 67;   y. a polypeptide from  Trichoderma  sp-54723 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 68;   z. a polypeptide from  Aspergillus niveus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 69;   aa. a polypeptide from  Aspergillus templicola  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 70;   bb. a polypeptide from  Pochonia chlamydosporia  var.  spinulospora  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 71;   cc. a polypeptide from  Trichoderma  sp-44174 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 35;   dd. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 37;   ee. a polypeptide from  Trichoderma  sp-54723 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 72;   ff. a polypeptide from  Trichoderma  sp-44174 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 73;   gg. a polypeptide from  Metapochonia suchlasporia  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 74;   hh. a polypeptide from  Metarhizium marquandii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 75;   ii. a polypeptide from  Diaporthe nobilis  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 76;   jj. a polypeptide from  Tolypocladium  sp. XZ2627 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 77;   kk. a polypeptide from  Aspergillus japonicus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 78;   ll. a polypeptide from  Metarhizium  sp. XZ2431 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 79;   mm. a polypeptide from  Armillaria ostoyae  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 80;   nn. a polypeptide from  Trichoderma spirale  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 81;   oo. a polypeptide from  Aspergillus elegans  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 82;   pp. a polypeptide from  Trichoderma sinuosum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 210;   qq. a polypeptide from  Trichoderma virens  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 211;   rr. a polypeptide from  Trichoderma harzianum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 212;   ss. a polypeptide from  Fusicolla acetilerea  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 213;   tt. a polypeptide from  Plectosphaerella  sp. 1-29 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 214;   uu. a polypeptide from  Mariannaea punicea  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 215;   vv. a polypeptide from  Penicillium oxalicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 216;   ww. a polypeptide from  Colletotrichum  sp-71086 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 217;   xx. a polypeptide from  Aspergillus  sp.  nov . XZ3202 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 218;   yy. a polypeptide from  Trichoderma parapiluliferum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 219;   zz. a polypeptide from  Aspergillus  sp.  nov . XZ3202 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 220;   aaa. a polypeptide from  Mucor  sp. XZ2651 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 238;   bbb. a polypeptide from  Rhizomucor miehei  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 239;   ccc. a polypeptide from  Mucor  sp. XZ2651 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 240;   ddd. a polypeptide from Amphisphaeriaceae -sp 43674 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 241;   eee. a polypeptide from  Humicola fuscoatra  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 242; and   fff. a polypeptide from  Valsaria rubricosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 243.       

     Metals of Superoxide Dismutases 
     In an embodiment of the invention the polypeptide having superoxide dismutase activity is of fungal origin and is selected from the group consisting of a Cu-SOD, a Zn-SOD, a Cu/Zn-SOD, a Mn-SOD, and an Fe-SOD, more typically a Cu-SOD, a Zn-SOD, a Cu/Zn-SOD, a Mn-SOD, and an Fe-SOD, even more typically a Cu-SOD, a Zn-SOD, a Cu/Zn-SOD, or a Mn-SOD. 
     In a suitable embodiment of the invention the polypeptide having superoxide dismutase activity is of fungal origin and is selected from the group consisting of a Cu-SOD and a Cu/Zn-SOD. 
     The copper ion is involved in the catalysis of Cu-SODs whereas the zinc ion plays a structural role. The redox active copper catalyzes the disproportionation of superoxide anion to oxygen and hydrogen peroxide, whereas the zinc helps stabilize the protein and promotes pH independence of the reaction. 
     
       
         
           
               
            
               
                   
               
               
                 Table of Metals 
               
            
           
           
               
               
               
               
               
            
               
                   
                 SEQ ID NO 
                 SEQ ID NO 
                 SEQ ID NO 
                   
               
               
                 Source 
                 Mature peptide 
                 Full polypeptide 
                 DNA 
                 Metal 
               
               
                   
               
               
                 
                   Trichoderma reesei 
                 
                 SED ID NO 1 
                 SEQ ID NO 83 
                 SEQ ID NO 5 
                 Cu 
               
               
                 
                   Aspergillus versicolor 
                 
                 SED ID NO 2 
                 SEQ ID NO 84 
                 SEQ ID NO 87 
                 Cu 
               
               
                 
                   Aspergillus deflectus 
                 
                 SEQ ID NO 3 
                 SEQ ID NO 85 
                 SEQ ID NO 88 
                 Cu/Zn 
               
               
                 
                   Aspergillus egyptiacus 
                 
                 SEQ ID NO 4 
                 SEQ ID NO 86 
                 SEQ ID NO 89 
                 Cu 
               
               
                   Westerdykella  sp. 
                 SEQ ID NO 9 
                 SEQ ID NO 49 
                 SEQ ID NO 90 
                 Fe 
               
               
                 AS85-2 
               
               
                   Aspergillus  sp. XZ2669 
                 SEQ ID NO 10 
                 SEQ ID NO 50 
                 SEQ ID NO 91 
                 Cu 
               
               
                 
                   Preussia terricola 
                 
                 SEQ ID NO 11 
                 SEQ ID NO 51 
                 SEQ ID NO 92 
                 Fe 
               
               
                   Kionochaeta  sp. 
                 SEQ ID NO 12 
                 SEQ ID NO 52 
                 SEQ ID NO 93 
                 Cu/Zn 
               
               
                   Kionochaeta  sp. 
                 SEQ ID NO 13 
                 SEQ ID NO 53 
                 SEQ ID NO 94 
                 Cu/Zn 
               
               
                 M etapochonia bulbillosa   
                 SEQ ID NO 14 
                 SEQ ID NO 54 
                 SEQ ID NO 95 
                 Cu 
               
               
                   Xylomelasma  sp. 
                 SEQ ID NO 15 
                 SEQ ID NO 55 
                 SEQ ID NO 96 
                 Cu 
               
               
                 XZ0718 
               
               
                 
                   Preussia flanaganii 
                 
                 SEQ ID NO 16 
                 SEQ ID NO 56 
                 SEQ ID NO 97 
                 Fe 
               
               
                   Cladobotryum  sp. 
                 SEQ ID NO 17 
                 SEQ ID NO 18 
                 SEQ ID NO 98 
                 Fe 
               
               
                   Westerdykella  sp- 
                 SEQ ID NO 19 
                 SEQ ID NO 57 
                 SEQ ID NO 99 
                 Fe 
               
               
                 46156 
               
               
                 
                   Trichoderma hamatum 
                 
                 SEQ ID NO 20 
                 SEQ ID NO 58 
                 SEQ ID NO 100 
                 Fe 
               
               
                 Mycothermus thermophilus 
                 SEQ ID NO 21 
                 SEQ ID NO 59 
                 SEQ ID NO 101 
                 Cu/Zn 
               
               
                 
                   Cephalotrichiella penicillata 
                 
                 SEQ ID NO 22 
                 SEQ ID NO 60 
                 SEQ ID NO 102 
                 Fe 
               
               
                 Chaetomium 
                 SEQ ID NO 23 
                 SEQ ID NO 61 
                 SEQ ID NO 127 
                 Fe 
               
               
                 megalocarpum 
               
               
                 
                   Chaetomium thermophilum 
                 
                 SEQ ID NO 24 
                 SEQ ID NO 62 
                 SEQ ID NO 128 
                 Fe 
               
               
                 var.  thermophilum   
               
               
                 
                   Humicola hyalothermophila 
                 
                 SEQ ID NO 25 
                 SEQ ID NO 63 
                 SEQ ID NO 129 
                 Fe 
               
               
                 
                   Subramaniula anamorphosa 
                 
                 SEQ ID NO 26 
                 SEQ ID NO 64 
                 SEQ ID NO 130 
                 Fe 
               
               
                   Sphingobacterium  sp. 
                 SEQ ID NO 27 
                 SEQ ID NO 65 
                 SEQ ID NO 131 
                 Fe 
               
               
                 T2 
               
               
                 
                   Trichoderma rossicum 
                 
                 SEQ ID NO 28 
                 SEQ ID NO 66 
                 SEQ ID NO 132 
                 Cu 
               
               
                 
                   Trichoderma lixii 
                 
                 SEQ ID NO 29 
                 SEQ ID NO 67 
                 SEQ ID NO 133 
                 Cu 
               
               
                   Trichoderma  sp-54723 
                 SEQ ID NO 30 
                 SEQ ID NO 68 
                 SEQ ID NO 134 
                 Cu 
               
               
                 
                   Aspergillus niveus 
                 
                 SEQ ID NO 31 
                 SEQ ID NO 69 
                 SEQ ID NO 135 
                 Cu 
               
               
                 
                   Aspergillus templicola 
                 
                 SEQ ID NO 32 
                 SEQ ID NO 70 
                 SEQ ID NO 136 
                 Cu 
               
               
                 
                   Pochonia chlamydosporia 
                 
                 SEQ ID NO 33 
                 SEQ ID NO 71 
                 SEQ ID NO 137 
                 Cu 
               
               
                 var.  spinulospora   
               
               
                   Trichoderma  sp-44174 
                 SEQ ID NO 34 
                 SEQ ID NO 35 
                 SEQ ID NO 138 
                 Cu 
               
               
                 
                   Trichoderma rossicum 
                 
                 SEQ ID NO 36 
                 SEQ ID NO 37 
                 SEQ ID NO 139 
                 Cu 
               
               
                   Trichoderma  sp-54723 
                 SEQ ID NO 38 
                 SEQ ID NO 72 
                 SEQ ID NO 140 
                 Cu 
               
               
                   Trichoderma  sp-44174 
                 SEQ ID NO 39 
                 SEQ ID NO 73 
                 SEQ ID NO 141 
                 Cu 
               
               
                 
                   Metapochonia suchlasporia 
                 
                 SEQ ID NO 40 
                 SEQ ID NO 74 
                 SEQ ID NO 142 
                 Cu 
               
               
                 
                   Metarhizium marquandii 
                 
                 SEQ ID NO 41 
                 SEQ ID NO 75 
                 SEQ ID NO 143 
                 Cu 
               
               
                   Diaporthe nobili s 
                 SEQ ID NO 42 
                 SEQ ID NO 76 
                 SEQ ID NO 144 
                 Cu 
               
               
                   Tolypocladium  sp. 
                 SEQ ID NO 43 
                 SEQ ID NO 77 
                 SEQ ID NO 145 
                 Cu/Zn 
               
               
                 XZ2627 
               
               
                 
                   Aspergillus japonicus 
                 
                 SEQ ID NO 44 
                 SEQ ID NO 78 
                 SEQ ID NO 146 
                 Cu 
               
               
                   Metarhizium  sp. 
                 SEQ ID NO 45 
                 SEQ ID NO 79 
                 SEQ ID NO 147 
                 Cu 
               
               
                 XZ2431 
               
               
                 Armillaria ostoyae 
                 SEQ ID NO 46 
                 SEQ ID NO 80 
                 SEQ ID NO 148 
                 Cu/Zn 
               
               
                 
                   Trichoderma spirale 
                 
                 SEQ ID NO 47 
                 SEQ ID NO 81 
                 SEQ ID NO 149 
                 Cu 
               
               
                 
                   Aspergillus elegans 
                 
                 SEQ ID NO 48 
                 SEQ ID NO 82 
                 SEQ ID NO 150 
                 Cu/Zn 
               
               
                 
                   Trichoderma sinuosum 
                 
                 SEQ ID NO 199 
                 SEQ ID NO 210 
                 SEQ ID NO 221 
                 Cu 
               
               
                 
                   Trichoderma virens 
                 
                 SEQ ID NO 200 
                 SEQ ID NO 211 
                 SEQ ID NO 222 
                 Cu/Zn 
               
               
                 
                   Trichoderma 
                 
                 SEQ ID NO 201 
                 SEQ ID NO 212 
                 SEQ ID NO 223 
                 Cu 
               
               
                 
                   harzianum 
                 
               
               
                 Fusicolla acetilerea 
                 SEQ ID NO 202 
                 SEQ ID NO 213 
                 SEQ ID NO 224 
                 Cu/Zn 
               
               
                   Plectosphaerella  sp. 1- 
                 SEQ ID NO 203 
                 SEQ ID NO 214 
                 SEQ ID NO 225 
                 Cu/Zn 
               
               
                 29 
               
               
                 Mariannaea punicea 
                 SEQ ID NO 204 
                 SEQ ID NO 215 
                 SEQ ID NO 226 
                 Cu/Zn 
               
               
                 Penicillium oxalicum 
                 SEQ ID NO 205 
                 SEQ ID NO 216 
                 SEQ ID NO 227 
                 Cu/Zn 
               
               
                   Colletotrichum  sp- 
                 SEQ ID NO 206 
                 SEQ ID NO 217 
                 SEQ ID NO 228 
                 Cu 
               
               
                 71086 
               
               
                   Aspergillus  sp. nov. 
                 SEQ ID NO 207 
                 SEQ ID NO 218 
                 SEQ ID NO 229 
                 Cu/Zn 
               
               
                 XZ3202 
               
               
                 
                   Trichoderma 
                 
                 SEQ ID NO 208 
                 SEQ ID NO 219 
                 SEQ ID NO 230 
                 Cu 
               
               
                 
                   parapiluliferum 
                 
               
               
                   Aspergillus  sp. nov. 
                 SEQ ID NO 209 
                 SEQ ID NO 220 
                 SEQ ID NO 231 
                 Cu 
               
               
                 XZ3202 
               
               
                   Mucor  sp. XZ2651 
                 SEQ ID NO 232 
                 SEQ ID NO 238 
                 SEQ ID NO 244 
                 Cu 
               
               
                 Rhizomucor miehei 
                 SEQ ID NO 233 
                 SEQ ID NO 239 
                 SEQ ID NO 245 
                 Cu 
               
               
                   Mucor  sp. XZ2651 
                 SEQ ID NO 234 
                 SEQ ID NO 240 
                 SEQ ID NO 246 
                 Cu 
               
               
                 Amphisphaeriaceae 
                 SEQ ID NO 235 
                 SEQ ID NO 241 
                 SEQ ID NO 247 
                 Cu 
               
               
                 sp-43674 
               
               
                 
                   Humicola fuscoatra 
                 
                 SEQ ID NO 236 
                 SEQ ID NO 242 
                 SEQ ID NO 248 
                 Cu/Zn 
               
               
                 Valsaria rubricosa 
                 SEQ ID NO 237 
                 SEQ ID NO 243 
                 SEQ ID NO 249 
                 Cu 
               
               
                   
               
            
           
         
       
     
     Catalytic Site of Superoxide Dismutases 
     In an embodiment of the invention, the polypeptide having superoxide dismutase activity has a conserved catalytic site selected from the group consisting of H69, H71, H86, H150; H66, H68, H84, H148; H66, H68, H84, H148; H68, H70, H85, H149; H69, H71, H86, H150: H68, H70, H86, H150; H62, H64, H80, H144; H44, H46, H61, H118; H79, H81, H97, H161: H82, H84, H100, H164; H65, H67, H83, H150; H45, H47, H62, H119; H67, H69, H85, H149; H50, H52, H67, H126; H67, H69, H85, H149; H63, H65, H81, H148; H67, H69, H85, H149; H62, H64, H80, H147; H62, H64, H80, H147; H68, H70, H85, H149; H69, H71, H86, H150; H75, H77, H93, H156; H61, H63, H79, H146; H68, H70, H85, H149.
 
In a suitable embodiment, the SOD of the invention is a polypeptide having super oxide dismutase activity is selected from the group consisting of
         i. a polypeptide which has at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 34, comprises amino acid residues H69, H71, H86, H150 at its catalytic site and suitably obtainable from  Trichoderma  sp-44174;   ii. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 39, comprises amino acid residues H69, H71, H86, H150 at its catalytic site and suitably obtainable from  Trichoderma  sp-44174;   iii. a polypeptide which invention has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 33, comprises amino acid residues H66, H68, H84, H148 at its catalytic site and suitably obtainable from  Pochonia chlamydosporia  var.  spinulospora . iv. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 37, comprises amino acid residues H68, H70, H85, H149 at its catalytic site and suitably obtainable from  Trichoderma  sp-54723;   v. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 28, comprises amino acid residues H69, H71, H86, H150 at its catalytic site and suitably obtainable from  Trichoderma rossicum;      vi. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 45, comprises amino acid residues H68, H70, H86, H150 at its catalytic site and suitably obtainable from  Metarhizium  sp. XZ2431;   vii. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 29, comprises amino acid residues H69, H71, H86, H150 at its catalytic site and suitably obtainable from  Trichoderma lixii;      viii. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 12, comprises amino acid residues H69, H71, H86, H150 at its catalytic site and suitably obtainable from  Kionochaeta  sp;   ix. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 21, comprises amino acid residues H44, H46, H61, H118 at its catalytic site and suitably obtainable from  Mycothermus thermophilus;      x. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 30, comprises amino acid residues H68, H70, H85, H149 at its catalytic site and suitably obtainable from  Trichoderma  sp-54723;   xi. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 13, comprises amino acid residues H79, H81, H97, H161 at its catalytic site and suitably obtainable from  Kionochaeta  sp;   xii. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 15, comprises amino acid residues H82, H84, H100, H164 at its catalytic site and suitably obtainable from  Xylomelasma  sp. XZ0718;   xiii. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 48, comprises amino acid residues H65, H67, H83, H150 at its catalytic site and suitably obtainable from  Aspergillus elegans;      xiv. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 14, comprises amino acid residues H67, H69, H85, H149 at its catalytic site and suitably obtainable from  Metapochonia bulbillosa;      xv. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 46, comprises amino acid residues H50, H52, H67, H126 at its catalytic site and suitably obtainable from  Armillaria ostoyae;      xvi. a polypeptide which invention has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 40, comprises amino acid residues H67, H69, H85, H149 at its catalytic site and suitably obtainable from  Metapochonia suchlasporia;      xvii. a polypeptide which as a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 31, comprises amino acid residues H63, H65, H81, H148 at its catalytic site and suitably obtainable from  Aspergillus niveus;      xviii. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 41, comprises amino acid residues H67, H69, H85, H149 at its catalytic site and suitably obtainable from  Metarhizium marquandii;      xix. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 10, comprises amino acid residues H62, H64, H80, H147 at its catalytic site and suitably obtainable from  Aspergillus  sp. XZ2669;   xx. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 32, comprises amino acid residues H62, H64, H80, H147 at its catalytic site and suitably obtainable from  Aspergillus templicola;      xxi. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 35, comprises amino acid residues H69, H71, H86, H150 at its catalytic site and suitably obtainable from  Trichoderma  rossicum;   xxii. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 42, comprises amino acid residues H75, H77, H93, H156 at its catalytic site and suitably obtainable from  Diaporthe nobilis;      xxiii. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 44, comprises amino acid residues H61, H63, H79, H146 at its catalytic site and suitably obtainable from  Aspergillus japonicus;      xxiv. a polypeptide which has a at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 43, comprises amino acid residues H68, H70, H85, H149 at its catalytic site and suitably obtainable from  Tolypocladium  sp. XZ2627; and   xxv. a polypeptide which has at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with the Cu-SOD of SEQ ID NO: 47, comprises amino acid residues H69, H71, H86, H150 at its catalytic site and suitably obtainable from  Trichoderma spirale.          

     Activity of Superoxide Dismutases 
     In a preferred embodiment, the SOD of the invention has an activity level above 1000 U/mg EP when measured according to the method described in Example 9 at pH 7.8. Accordingly, in one embodiment of the invention the SOD is selected from a polypeptide which has at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with a mature polypeptide selected from the group consisting of SEQ ID NO 1, SEQ ID NO 15, SEQ ID NO 21, SEQ ID NO 24, SEQ ID NO 28, SEQ ID NO 29, SEQ ID NO 30, SEQ ID NO 31, SEQ ID NO 32, SEQ ID NO 33, SEQ ID NO 34, SEQ ID NO 35, SEQ ID NO 39, SEQ ID NO 41, SEQ ID NO 42, SEQ ID NO 44, SEQ ID NO 45, SEQ ID NO 48, SEQ ID NO 202, SEQ ID NO 203, SEQ ID NO 204, SEQ ID NO 205, SEQ ID NO 206, SEQ ID NO 207, SEQ ID NO 208, SEQ ID NO 209, SEQ ID NO 232, SEQ ID NO 233, SEQ ID NO 234, SEQ ID NO 235, SEQ ID NO 236, SEQ ID NO 237 or with a full length polypeptide selected from the group consisting of SEQ ID NO 83, SEQ ID NO 50, SEQ ID NO 51, SEQ ID NO 52, SEQ ID NO 53, SEQ ID NO 54, SEQ ID NO 55, SEQ ID NO 56, SEQ ID NO 18, SEQ ID NO 57, SEQ ID NO 59, SEQ ID NO 60, SEQ ID NO 61, SEQ ID NO 62, SEQ ID NO 63, SEQ ID NO 64, SEQ ID NO 65, SEQ ID NO 66, SEQ ID NO 67, SEQ ID NO 68, SEQ ID NO 69, SEQ ID NO 70, SEQ ID NO 71, SEQ ID NO 35, SEQ ID NO 37, SEQ ID NO 72, SEQ ID NO 73, SEQ ID NO 74, SEQ ID NO 75, SEQ ID NO 76, SEQ ID NO 77, SEQ ID NO 78, SEQ ID NO 79, SEQ ID NO 80, SEQ ID NO 81, SEQ ID NO 82, SEQ ID NO 210, SEQ ID NO 211, SEQ ID NO 212, SEQ ID NO 213, SEQ ID NO 214, SEQ ID NO 215, SEQ ID NO 216, SEQ ID NO 217, SEQ ID NO 218, SEQ ID NO 219, SEQ ID NO 220, SEQ ID NO 238, SEQ ID NO 239, SEQ ID NO 240, SEQ ID NO 241, SEQ ID NO 242 and SEQ ID NO 243. 
     
       
         
           
               
            
               
                   
               
               
                 Activity Table 
               
            
           
           
               
               
               
               
            
               
                   
                 Mature polypeptide 
                 Full polypeptide 
                 Relative Activity 
               
               
                 Source 
                 SEQ ID NO 
                 SEQ ID NO 
                 Unit (U/mg EP) 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 
                   Trichoderma reesei 
                 
                 SED ID NO 1 
                 SEQ ID NO 83 
                 6055 
               
               
                   Westerdykella  sp. AS85-2 
                 SEQ ID NO 9 
                 SEQ ID NO 49 
                 699 
               
               
                   Aspergillus  sp. XZ2669 
                 SEQ ID NO 10 
                 SEQ ID NO 50 
                 1000 
               
               
                 
                   Preussia terricola 
                 
                 SEQ ID NO 11 
                 SEQ ID NO 51 
                 634 
               
               
                   Kionochaeta  sp. 
                 SEQ ID NO 12 
                 SEQ ID NO 52 
                 1184 
               
               
                   Kionochaeta  sp. 
                 SEQ ID NO 13 
                 SEQ ID NO 53 
                 2108 
               
               
                 
                   Metapochonia bulbillosa 
                 
                 SEQ ID NO 14 
                 SEQ ID NO 54 
                 1494 
               
               
                   Xylomelasma  sp. XZ0718 
                 SEQ ID NO 15 
                 SEQ ID NO 55 
                 3900 
               
               
                 
                   Preussia flanaganii 
                 
                 SEQ ID NO 16 
                 SEQ ID NO 56 
                 1451 
               
               
                   Cladobotryum  sp. 
                 SEQ ID NO 17 
                 SEQ ID NO 18 
                 na 
               
               
                   Westerdykella  sp-46156 
                 SEQ ID NO 19 
                 SEQ ID NO 57 
                 1309 
               
               
                 
                   Trichoderma hamatum 
                 
                 SEQ ID NO 20 
                 SEQ ID NO 58 
                 388 
               
               
                 Mycothermus thermophilus 
                 SEQ ID NO 21 
                 SEQ ID NO 59 
                 2678 
               
               
                 
                   Cephalotrichiella penicillata 
                 
                 SEQ ID NO 22 
                 SEQ ID NO 60 
                 1034 
               
               
                 
                   Chaetomium megalocarpum 
                 
                 SEQ ID NO 23 
                 SEQ ID NO 61 
                 1641 
               
               
                 
                   Chaetomium thermophilum 
                 
                 SEQ ID NO 24 
                 SEQ ID NO 62 
                 2451 
               
               
                 var.  thermophilum   
               
               
                 
                   Humicola hyalothermophila 
                 
                 SEQ ID NO 25 
                 SEQ ID NO 63 
                 1293 
               
               
                 
                   Subramaniula anamorphosa 
                 
                 SEQ ID NO 26 
                 SEQ ID NO 64 
                 na 
               
               
                   Sphingobacterium  sp. T2 
                 SEQ ID NO 27 
                 SEQ ID NO 65 
                 279 
               
               
                 
                   Trichoderma rossicum 
                 
                 SEQ ID NO 28 
                 SEQ ID NO 66 
                 1889 
               
               
                 
                   Trichoderma lixii 
                 
                 SEQ ID NO 29 
                 SEQ ID NO 67 
                 2701 
               
               
                   Trichoderma  sp-54723 
                 SEQ ID NO 30 
                 SEQ ID NO 68 
                 2662 
               
               
                 
                   Aspergillus niveus 
                 
                 SEQ ID NO 31 
                 SEQ ID NO 69 
                 3646 
               
               
                 
                   Aspergillus templicola 
                 
                 SEQ ID NO 32 
                 SEQ ID NO 70 
                 5483 
               
               
                 
                   Pochonia chlamydosporia 
                 
                 SEQ ID NO 33 
                 SEQ ID NO 71 
                 2026 
               
               
                 var.  Spinulospora   
               
               
                   Trichoderma  sp-44174 
                 SEQ ID NO 34 
                 SEQ ID NO 35 
                 2937 
               
               
                 
                   Trichoderma rossicum 
                 
                 SEQ ID NO 36 
                 SEQ ID NO 37 
                 2615 
               
               
                   Trichoderma  sp-54723 
                 SEQ ID NO 38 
                 SEQ ID NO 72 
                 1298 
               
               
                   Trichoderma  sp-44174 
                 SEQ ID NO 39 
                 SEQ ID NO 73 
                 2314 
               
               
                 
                   Metapochonia suchlasporia 
                 
                 SEQ ID NO 40 
                 SEQ ID NO 74 
                 1938 
               
               
                 
                   Metarhizium marquandii 
                 
                 SEQ ID NO 41 
                 SEQ ID NO 75 
                 2808 
               
               
                 
                   Diaporthe nobilis 
                 
                 SEQ ID NO 42 
                 SEQ ID NO 76 
                 4348 
               
               
                   Tolypocladium  sp. 
                 SEQ ID NO 43 
                 SEQ ID NO 77 
                 2052 
               
               
                 XZ2627 
               
               
                 
                   Aspergillus japonicus 
                 
                 SEQ ID NO 44 
                 SEQ ID NO 78 
                 7754 
               
               
                   Metarhizium  sp. XZ2431 
                 SEQ ID NO 45 
                 SEQ ID NO 79 
                 6941 
               
               
                 Armillaria ostoyae 
                 SEQ ID NO 46 
                 SEQ ID NO 80 
                 1877 
               
               
                 
                   Trichoderma spirale 
                 
                 SEQ ID NO 47 
                 SEQ ID NO 81 
                 1290 
               
               
                 
                   Aspergillus elegans 
                 
                 SEQ ID NO 48 
                 SEQ ID NO 82 
                 2651 
               
               
                 
                   Trichoderma sinuosum 
                 
                 SEQ ID NO 199 
                 SEQ ID NO 210 
                 328 
               
               
                 
                   Trichoderma virens 
                 
                 SEQ ID NO 200 
                 SEQ ID NO 211 
                 684 
               
               
                 
                   Trichoderma harzianum 
                 
                 SEQ ID NO 201 
                 SEQ ID NO 212 
                 654 
               
               
                 Fusicolla acetilerea 
                 SEQ ID NO 202 
                 SEQ ID NO 213 
                 9527 
               
               
                   Plectosphaerella  sp. 1-29 
                 SEQ ID NO 203 
                 SEQ ID NO 214 
                 5952 
               
               
                 Mariannaea punicea 
                 SEQ ID NO 204 
                 SEQ ID NO 215 
                 4410 
               
               
                 Penicillium oxalicum 
                 SEQ ID NO 205 
                 SEQ ID NO 216 
                 16555 
               
               
                   Colletotrichum  sp-71086 
                 SEQ ID NO 206 
                 SEQ ID NO 217 
                 2483 
               
               
                   Aspergillus  sp. nov. 
                 SEQ ID NO 207 
                 SEQ ID NO 218 
                 4018 
               
               
                 XZ3202 
               
               
                 
                   Trichoderma 
                 
                 SEQ ID NO 208 
                 SEQ ID NO 219 
                 2525 
               
               
                 
                   parapiluliferum 
                 
               
               
                   Aspergillus  sp. nov. 
                 SEQ ID NO 209 
                 SEQ ID NO 220 
                 5287 
               
               
                 XZ3202 
               
               
                   Mucor  sp. XZ2651 
                 SEQ ID NO 232 
                 SEQ ID NO 238 
                 3,762 
               
               
                 Rhizomucor miehei 
                 SEQ ID NO 233 
                 SEQ ID NO 239 
                 4,406 
               
               
                   Mucor  sp. XZ2651 
                 SEQ ID NO 234 
                 SEQ ID NO 240 
                 8,182 
               
               
                 Amphisphaeriaceae sp- 
                 SEQ ID NO 235 
                 SEQ ID NO 241 
                 3,018 
               
               
                 43674 
               
               
                 
                   Humicola fuscoatra 
                 
                 SEQ ID NO 236 
                 SEQ ID NO 242 
                 5,744 
               
               
                 Valsaria rubricosa 
                 SEQ ID NO 237 
                 SEQ ID NO 243 
                 2,977 
               
               
                   
               
            
           
         
       
     
     In one embodiment of the invention, the superoxide dismutase of fungal origin has an activity of at least 1000 U/mg at pH 7.8, such as at least 1500 U/mg, or at least 2000 U/mg, or at least 3000 U/mg, or at least 4000 U/mg, or at least 5000 U/mg, suitably as measured by the method described in Example 9. 
     SEQ ID NO 1, SEQ ID NO 9, SEQ ID NO 15, SEQ ID NO 21, SEQ ID NO 24, SEQ ID NO 28, SEQ ID NO 29, SEQ ID NO 30, SEQ ID NO 31, SEQ ID NO 32, SEQ ID NO 33, SEQ ID NO 34, SEQ ID NO 35, SEQ ID NO 39, SEQ ID NO 41, SEQ ID NO 42, SEQ ID NO 44, SEQ ID NO 45, and SEQ ID NO 48 all have an activity near, at or over 3000 U/mg EP when measured according to the method described in Example 9 or at pH 7.8. 
     Gastric Stability of Superoxide Dismutases 
     In a preferred embodiment, the SOD, given it is intended for use as an animal feed additive, is gastric stable, when measured according to the method described in Example 10. As can be seen from the table in Example 10, the commercially available superoxide dismutase from bovine erythrocytes and expressed in  E. coli  of sequence A: 
                    MATKAVCVLKGDGPVQGTIHFEAKGDTVVVTGSITGLTEGDHGFHVHQFG               DNTQGCTSAGPHFNPLSKKHGGPKDEERHVGDLGNVTADKNGVAIVDIVD               PLISLSGEYSIIGRTMVVHEKPDDLGRGGNEESTKTGNAGSRLACGVIGI               AK            
retains only 26% of its activity upon gastric treatment in the presence of pepsin.
 
     Two commercial SODs were tested as references: SOD-Mn, from  E. coli  Sigma S5639 with a activity of 10240 U/mg EP and only 26% activity left after gastric press for 30 min; and SOD-Cu/Zn from Bovine expressed in  E. coli  Sigma S9697 with activity of 6108 U/mg EP and only 35% activity left after gastric press for 30 min. 
     The fungal SODs of the invention were overwhelmingly and surprisingly found to have a very high gastric stability (see Gastric Stability Table). Moreover, some SODs even have higher activity under gastric stability studies than at the reference pH, indicating that they are more active at low pH. This makes fungal SODs very well suited for use in vivo by means of administration through animal feed. 
     
       
         
           
               
            
               
                   
               
               
                 Gastric Stability Table 
               
            
           
           
               
               
               
               
            
               
                   
                   
                   
                 Gastric stability after 
               
               
                   
                 SEQ ID NO 
                 SEQ ID NO 
                 15 min (remaining 
               
               
                 Source 
                 Mature peptide 
                 Full polypeptide 
                 activity, approx, %) 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 
                   Trichoderma reesei 
                 
                 SED ID NO 1 
                 SEQ ID NO 83 
                 100 
               
               
                 
                   Preussia terricola 
                 
                 SEQ ID NO 11 
                 SEQ ID NO 51 
                 70 
               
               
                   Kionochaeta  sp. 
                 SEQ ID NO 12 
                 SEQ ID NO 52 
                 88 
               
               
                   Kionochaeta  sp. 
                 SEQ ID NO 13 
                 SEQ ID NO 53 
                 92 
               
               
                 
                   Metapochonia bulbillosa 
                 
                 SEQ ID NO 14 
                 SEQ ID NO 54 
                 100 
               
               
                   Xylomelasma  sp. XZ0718 
                 SEQ ID NO 15 
                 SEQ ID NO 55 
                 100 
               
               
                 
                   Preussia flanaganii 
                 
                 SEQ ID NO 16 
                 SEQ ID NO 56 
                 90 
               
               
                   Cladobotryum  sp. 
                 SEQ ID NO 17 
                 SEQ ID NO 18 
                 100 
               
               
                   Westerdykella  sp-46156 
                 SEQ ID NO 19 
                 SEQ ID NO 57 
                 52 
               
               
                 
                   Trichoderma hamatum 
                 
                 SEQ ID NO 20 
                 SEQ ID NO 58 
                 98 
               
               
                 Mycothermus thermophilus 
                 SEQ ID NO 21 
                 SEQ ID NO 59 
                 40 
               
               
                 
                   Cephalotrichiella penicillata 
                 
                 SEQ ID NO 22 
                 SEQ ID NO 60 
                 85 
               
               
                 
                   Chaetomium megalocarpum 
                 
                 SEQ ID NO 23 
                 SEQ ID NO 61 
                 45 
               
               
                 
                   Chaetomium thermophilum 
                 
                 SEQ ID NO 24 
                 SEQ ID NO 62 
                 57 
               
               
                 var.  Thermophilum   
               
               
                 
                   Humicola hyalothermophila 
                 
                 SEQ ID NO 25 
                 SEQ ID NO 63 
                 62 
               
               
                 
                   Subramaniula anamorphosa 
                 
                 SEQ ID NO 26 
                 SEQ ID NO 64 
                 97 
               
               
                   Sphingobacterium  sp. T2 
                 SEQ ID NO 27 
                 SEQ ID NO 65 
                 78 
               
               
                 
                   Trichoderma rossicum 
                 
                 SEQ ID NO 28 
                 SEQ ID NO 66 
                 128 
               
               
                 
                   Trichoderma lixii 
                 
                 SEQ ID NO 29 
                 SEQ ID NO 67 
                 144 
               
               
                   Trichoderma  sp-54723 
                 SEQ ID NO 30 
                 SEQ ID NO 68 
                 124 
               
               
                 
                   Aspergillus niveus 
                 
                 SEQ ID NO 31 
                 SEQ ID NO 69 
                 126 
               
               
                 
                   Aspergillus templicola 
                 
                 SEQ ID NO 32 
                 SEQ ID NO 70 
                 90 
               
               
                   Pochonia chlamydosporia  var. 
                 SEQ ID NO 33 
                 SEQ ID NO 71 
                 105 
               
               
                 
                   Spinulospora 
                 
               
               
                   Trichoderma  sp-44174 
                 SEQ ID NO 34 
                 SEQ ID NO 35 
                 120 
               
               
                 
                   Trichoderma rossicum 
                 
                 SEQ ID NO 36 
                 SEQ ID NO 37 
                 96 
               
               
                   Trichoderma  sp-54723 
                 SEQ ID NO 38 
                 SEQ ID NO 72 
                 100 
               
               
                   Trichoderma  sp-44174 
                 SEQ ID NO 39 
                 SEQ ID NO 73 
                 104 
               
               
                 
                   Metapochonia suchlasporia 
                 
                 SEQ ID NO 40 
                 SEQ ID NO 74 
                 83 
               
               
                 
                   Metarhizium marquandii 
                 
                 SEQ ID NO 41 
                 SEQ ID NO 75 
                 118 
               
               
                 
                   Diaporthe nobilis 
                 
                 SEQ ID NO 42 
                 SEQ ID NO 76 
                 98 
               
               
                   Tolypocladium  sp. XZ2627 
                 SEQ ID NO 43 
                 SEQ ID NO 77 
                 109 
               
               
                 
                   Aspergillus japonicus 
                 
                 SEQ ID NO 44 
                 SEQ ID NO 78 
                 104 
               
               
                   Metarhizium  sp. XZ2431 
                 SEQ ID NO 45 
                 SEQ ID NO 79 
                 104 
               
               
                 Armillaria ostoyae 
                 SEQ ID NO 46 
                 SEQ ID NO 80 
                 79 
               
               
                 
                   Trichoderma spirale 
                 
                 SEQ ID NO 47 
                 SEQ ID NO 81 
                 41 
               
               
                 
                   Aspergillus elegans 
                 
                 SEQ ID NO 48 
                 SEQ ID NO 82 
                 61 
               
               
                 
                   Trichoderma sinuosum 
                 
                 SEQ ID NO 199 
                 SEQ ID NO 210 
                 99 
               
               
                 
                   Trichoderma virens 
                 
                 SEQ ID NO 200 
                 SEQ ID NO 211 
                 73 
               
               
                 
                   Trichoderma harzianum 
                 
                 SEQ ID NO 201 
                 SEQ ID NO 212 
                 80 
               
               
                 Fusicolla acetilerea 
                 SEQ ID NO 202 
                 SEQ ID NO 213 
                 25 
               
               
                   Plectosphaerella  sp. 1-29 
                 SEQ ID NO 203 
                 SEQ ID NO 214 
                 23 
               
               
                 Mariannaea punicea 
                 SEQ ID NO 204 
                 SEQ ID NO 215 
                 23 
               
               
                 Penicillium oxalicum 
                 SEQ ID NO 205 
                 SEQ ID NO 216 
                 30 
               
               
                   Colletotrichum  sp-71086 
                 SEQ ID NO 206 
                 SEQ ID NO 217 
                 81 
               
               
                   Aspergillus  sp. nov. XZ3202 
                 SEQ ID NO 207 
                 SEQ ID NO 218 
                 72 
               
               
                 
                   Trichoderma parapiluliferum 
                 
                 SEQ ID NO 208 
                 SEQ ID NO 219 
                 97 
               
               
                   Aspergillus  sp. nov. XZ3202 
                 SEQ ID NO 209 
                 SEQ ID NO 220 
                 92 
               
               
                   Mucor  sp. XZ2651 
                 SEQ ID NO 232 
                 SEQ ID NO 238 
                 99 
               
               
                 Rhizomucor miehei 
                 SEQ ID NO 233 
                 SEQ ID NO 239 
                 90 
               
               
                   Mucor  sp. XZ2651 
                 SEQ ID NO 234 
                 SEQ ID NO 240 
                 113 
               
               
                 Amphisphaeriaceae sp- 
                 SEQ ID NO 235 
                 SEQ ID NO 241 
                 34 
               
               
                 43674 
               
               
                 
                   Humicola fuscoatra 
                 
                 SEQ ID NO 236 
                 SEQ ID NO 242 
                 57 
               
               
                 Valsaria rubricosa 
                 SEQ ID NO 237 
                 SEQ ID NO 243 
                 72 
               
               
                 S5639 from Sigma Mn-SOD 
                   
                   
                 26 
               
               
                 
                   Escherichia coli 
                 
               
               
                 S9697 Bovine Cu/Zn SOD 
                   
                   
                 35 
               
               
                 SIGMA 
               
               
                   
               
            
           
         
       
     
     One aspect of the invention is directed to an animal feed additive comprising a superoxide dismutase of fungal origin, wherein the superoxide dismutase retains 40% activity, at least 50% activity, such as retains at least 55% activity, such as retains at least 60% activity, such as retains at least 65% activity, such as retains at least 70% activity, such as retaining at least 75% activity, such as retains at least 80% activity, most preferably at least 85% activity, or 90%, or 95% activity under gastric stability studies as measure by the method of Example 10. 
     One aspect of the invention is directed to an animal feed additive comprising a fungal superoxide dismutase wherein the superoxide dismutase has improved gastric stability compared to sequence A, such that the superoxide dismutase is gastric stable such that it retains at least 40% of its activity when measured according to the test method described in Example 10, such as retaining at least 50% activity, such as retaining at least 55% activity, such as retaining at least 60% activity, such as retaining at least 65% activity, such as retaining at least 70% activity, such as retaining at least 75% activity, such as retaining at least 80% activity. 
     As can be seen from the Table in Example 10 and the Gastric Stability Table, each of SEQ ID NO 1, SEQ ID NO 83, SEQ ID NO 11, SEQ ID NO 51, SEQ ID NO 12, SEQ ID NO 52, SEQ ID NO 13, SEQ ID NO 53, SEQ ID NO 14, SEQ ID NO 54, SEQ ID NO 15, SEQ ID NO 55, SEQ ID NO 16, SEQ ID NO 56, SEQ ID NO 17, SEQ ID NO 18, SEQ ID NO 19, SEQ ID NO 57, SEQ ID NO 20, SEQ ID NO 58, SEQ ID NO 21, SEQ ID NO 59, SEQ ID NO 22, SEQ ID NO 60, SEQ ID NO 23, SEQ ID NO 61, SEQ ID NO 24, SEQ ID NO 62, SEQ ID NO 25, SEQ ID NO 63, SEQ ID NO 26, SEQ ID NO 64, SEQ ID NO 27, SEQ ID NO 65, SEQ ID NO 28, SEQ ID NO 66, SEQ ID NO 29, SEQ ID NO 67, SEQ ID NO 30, SEQ ID NO 68, SEQ ID NO 31, SEQ ID NO 69, SEQ ID NO 32, SEQ ID NO 70, SEQ ID NO 33, SEQ ID NO 71, SEQ ID NO 34, SEQ ID NO 35, SEQ ID NO 36, SEQ ID NO 37, SEQ ID NO 38, SEQ ID NO 72, SEQ ID NO 39, SEQ ID NO 73, SEQ ID NO 40, SEQ ID NO 74, SEQ ID NO 41, SEQ ID NO 75, SEQ ID NO 42, SEQ ID NO 76, SEQ ID NO 43, SEQ ID NO 77, SEQ ID NO 44, SEQ ID NO 78, SEQ ID NO 45, SEQ ID NO 79, SEQ ID NO 46, SEQ ID NO 80, SEQ ID NO 47, SEQ ID NO 81, SEQ ID NO 48, SEQ ID NO 82, SEQ ID NO 199, SEQ ID NO 210, SEQ ID NO 200, SEQ ID NO 211, SEQ ID NO 201, SEQ ID NO 212, SEQ ID NO 206, SEQ ID NO 217, SEQ ID NO 207, SEQ ID NO 218, SEQ ID NO 208, SEQ ID NO 219, SEQ ID NO 209, SEQ ID NO 220, SEQ ID NO 232, SEQ ID NO 238, SEQ ID NO 233, SEQ ID NO 239, SEQ ID NO 234, SEQ ID NO 240, SEQ ID NO 236, SEQ ID NO 242, SEQ ID NO 237 and SEQ ID NO 243 retain at least 40% of their activity under gastric stability studies, when measured according to the test method described in Example 10. 
     Accordingly, in one embodiment the polypeptide having superoxide dismutase activity may be selected a polypeptide having at least 80% sequence identity, such as at least 85% sequence identity, such as at least 90% sequence identity, such as at least 95% sequence identity, such as at least 98% sequence identity, such as at least 99% sequence identity of a polypeptide selected from the group consisting of SEQ ID NO 1, SEQ ID NO 83, SEQ ID NO 11, SEQ ID NO 51, SEQ ID NO 12, SEQ ID NO 52, SEQ ID NO 13, SEQ ID NO 53, SEQ ID NO 14, SEQ ID NO 54, SEQ ID NO 15, SEQ ID NO 55, SEQ ID NO 16, SEQ ID NO 56, SEQ ID NO 17, SEQ ID NO 18, SEQ ID NO 19, SEQ ID NO 57, SEQ ID NO 20, SEQ ID NO 58, SEQ ID NO 21, SEQ ID NO 59, SEQ ID NO 22, SEQ ID NO 60, SEQ ID NO 23, SEQ ID NO 61, SEQ ID NO 24, SEQ ID NO 62, SEQ ID NO 25, SEQ ID NO 63, SEQ ID NO 26, SEQ ID NO 64, SEQ ID NO 27, SEQ ID NO 65, SEQ ID NO 28, SEQ ID NO 66, SEQ ID NO 29, SEQ ID NO 67, SEQ ID NO 30, SEQ ID NO 68, SEQ ID NO 31, SEQ ID NO 69, SEQ ID NO 32, SEQ ID NO 70, SEQ ID NO 33, SEQ ID NO 71, SEQ ID NO 34, SEQ ID NO 35, SEQ ID NO 36, SEQ ID NO 37, SEQ ID NO 38, SEQ ID NO 72, SEQ ID NO 39, SEQ ID NO 73, SEQ ID NO 40, SEQ ID NO 74, SEQ ID NO 41, SEQ ID NO 75, SEQ ID NO 42, SEQ ID NO 76, SEQ ID NO 43, SEQ ID NO 77, SEQ ID NO 44, SEQ ID NO 78, SEQ ID NO 45, SEQ ID NO 79, SEQ ID NO 46, SEQ ID NO 80, SEQ ID NO 47, SEQ ID NO 81, SEQ ID NO 48, SEQ ID NO 82, SEQ ID NO 199, SEQ ID NO 210, SEQ ID NO 200, SEQ ID NO 211, SEQ ID NO 201, SEQ ID NO 212, SEQ ID NO 206, SEQ ID NO 217, SEQ ID NO 207, SEQ ID NO 218, SEQ ID NO 208, SEQ ID NO 219, SEQ ID NO 209, SEQ ID NO 220, SEQ ID NO 232, SEQ ID NO 238, SEQ ID NO 233, SEQ ID NO 239, SEQ ID NO 234, SEQ ID NO 240, SEQ ID NO 236, SEQ ID NO 242, SEQ ID NO 237 and SEQ ID NO 243. Typically, these SODs retain at least 40% of their activity under gastric stability studies, when measured according to the test method described in Example 10. 
     In a more preferred embodiment, the fungal SOD of the invention retains at least 50% of its activity under gastric stability studies. Accordingly, in more preferred embodiment, the polypeptide having superoxide dismutase activity may be selected a polypeptide having at least 80% sequence identity, such as at least 85% sequence identity, such as at least 90% sequence identity, such as at least 95% sequence identity, such as at least 98% sequence identity, such as at least 99% sequence identity of a polypeptide selected from the group consisting of SEQ ID NO 1, SEQ ID NO 83, SEQ ID NO 11, SEQ ID NO 51, SEQ ID NO 12, SEQ ID NO 52, SEQ ID NO 13, SEQ ID NO 53, SEQ ID NO 14, SEQ ID NO 54, SEQ ID NO 15, SEQ ID NO 55, SEQ ID NO 16, SEQ ID NO 56, SEQ ID NO 17, SEQ ID NO 18, SEQ ID NO 19, SEQ ID NO 57, SEQ ID NO 20, SEQ ID NO 58, SEQ ID NO 22, SEQ ID NO 60, SEQ ID NO 24, SEQ ID NO 62, SEQ ID NO 25, SEQ ID NO 63, SEQ ID NO 26, SEQ ID NO 64, SEQ ID NO 27, SEQ ID NO 65, SEQ ID NO 28, SEQ ID NO 66, SEQ ID NO 29, SEQ ID NO 67, SEQ ID NO 30, SEQ ID NO 68, SEQ ID NO 31, SEQ ID NO 69, SEQ ID NO 32, SEQ ID NO 70, SEQ ID NO 33, SEQ ID NO 71, SEQ ID NO 34, SEQ ID NO 35, SEQ ID NO 36, SEQ ID NO 37, SEQ ID NO 38, SEQ ID NO 72, SEQ ID NO 39, SEQ ID NO 73, SEQ ID NO 40, SEQ ID NO 74, SEQ ID NO 41, SEQ ID NO 75, SEQ ID NO 42, SEQ ID NO 76, SEQ ID NO 43, SEQ ID NO 77, SEQ ID NO 44, SEQ ID NO 78, SEQ ID NO 45, SEQ ID NO 79, SEQ ID NO 46, SEQ ID NO 80, SEQ ID NO 48, SEQ ID NO 82, SEQ ID NO 199, SEQ ID NO 210, SEQ ID NO 200, SEQ ID NO 211, SEQ ID NO 201, SEQ ID NO 212, SEQ ID NO 206, SEQ ID NO 217, SEQ ID NO 207, SEQ ID NO 218, SEQ ID NO 208, SEQ ID NO 219, SEQ ID NO 209, SEQ ID NO 220, SEQ ID NO 232, SEQ ID NO 238, SEQ ID NO 233, SEQ ID NO 239, SEQ ID NO 234, SEQ ID NO 240, SEQ ID NO 236, SEQ ID NO 242, SEQ ID NO 237 and SEQ ID NO 243. Typically, these SODs retain at least 50% of their activity under gastric stability studies, when measured according to the test method described in Example 10. 
     In a more preferred embodiment, the fungal SOD of the invention retains at least 60% of its activity under gastric stability studies. Accordingly, in more preferred embodiment, the polypeptide having superoxide dismutase activity may be selected a polypeptide having at least 80% sequence identity, such as at least 85% sequence identity, such as at least 90% sequence identity, such as at least 95% sequence identity, such as at least 98% sequence identity, such as at least 99% sequence identity of a polypeptide selected from the group consisting of SEQ ID NO 1, SEQ ID NO 83, SEQ ID NO 11, SEQ ID NO 51, SEQ ID NO 12, SEQ ID NO 52, SEQ ID NO 13, SEQ ID NO 53, SEQ ID NO 14, SEQ ID NO 54, SEQ ID NO 15, SEQ ID NO 55, SEQ ID NO 16, SEQ ID NO 56, SEQ ID NO 17, SEQ ID NO 18, SEQ ID NO 20, SEQ ID NO 58, SEQ ID NO 22, SEQ ID NO 60, SEQ ID NO 25, SEQ ID NO 63, SEQ ID NO 26, SEQ ID NO 64, SEQ ID NO 27, SEQ ID NO 65, SEQ ID NO 28, SEQ ID NO 66, SEQ ID NO 29, SEQ ID NO 67, SEQ ID NO 30, SEQ ID NO 68, SEQ ID NO 31, SEQ ID NO 69, SEQ ID NO 32, SEQ ID NO 70, SEQ ID NO 33, SEQ ID NO 71, SEQ ID NO 34, SEQ ID NO 35, SEQ ID NO 36, SEQ ID NO 37, SEQ ID NO 38, SEQ ID NO 72, SEQ ID NO 39, SEQ ID NO 73, SEQ ID NO 40, SEQ ID NO 74, SEQ ID NO 41, SEQ ID NO 75, SEQ ID NO 42, SEQ ID NO 76, SEQ ID NO 43, SEQ ID NO 77, SEQ ID NO 44, SEQ ID NO 78, SEQ ID NO 45, SEQ ID NO 79, SEQ ID NO 46, SEQ ID NO 80, SEQ ID NO 48, SEQ ID NO 82, SEQ ID NO 199, SEQ ID NO 210, SEQ ID NO 200, SEQ ID NO 211, SEQ ID NO 201, SEQ ID NO 212, SEQ ID NO 206, SEQ ID NO 217, SEQ ID NO 207, SEQ ID NO 218, SEQ ID NO 208, SEQ ID NO 219, SEQ ID NO 209, SEQ ID NO 220, SEQ ID NO 232, SEQ ID NO 238, SEQ ID NO 233, SEQ ID NO 239, SEQ ID NO 234, SEQ ID NO 240, SEQ ID NO 237 and SEQ ID NO 243. Typically, these SODs retain at least 60% of their activity under gastric stability studies, when measured according to the test method described in Example 10. 
     In a more preferred embodiment, the fungal SOD of the invention retains at least 70% of its activity under gastric stability studies. Accordingly, in more preferred embodiment, the polypeptide having superoxide dismutase activity may be selected a polypeptide having at least 80% sequence identity, such as at least 85% sequence identity, such as at least 90% sequence identity, such as at least 95% sequence identity, such as at least 98% sequence identity, such as at least 99% sequence identity of a polypeptide selected from the group consisting of SEQ ID NO 1, SEQ ID NO 83, SEQ ID NO 11, SEQ ID NO 51, SEQ ID NO 12, SEQ ID NO 52, SEQ ID NO 13, SEQ ID NO 53, SEQ ID NO 14, SEQ ID NO 54, SEQ ID NO 15, SEQ ID NO 55, SEQ ID NO 16, SEQ ID NO 56, SEQ ID NO 17, SEQ ID NO 18, SEQ ID NO 20, SEQ ID NO 58, SEQ ID NO 22, SEQ ID NO 60, SEQ ID NO 26, SEQ ID NO 64, SEQ ID NO 27, SEQ ID NO 65, SEQ ID NO 28, SEQ ID NO 66, SEQ ID NO 29, SEQ ID NO 67, SEQ ID NO 30, SEQ ID NO 68, SEQ ID NO 31, SEQ ID NO 69, SEQ ID NO 32, SEQ ID NO 70, SEQ ID NO 33, SEQ ID NO 71, SEQ ID NO 34, SEQ ID NO 35, SEQ ID NO 36, SEQ ID NO 37, SEQ ID NO 38, SEQ ID NO 72, SEQ ID NO 39, SEQ ID NO 73, SEQ ID NO 40, SEQ ID NO 74, SEQ ID NO 41, SEQ ID NO 75, SEQ ID NO 42, SEQ ID NO 76, SEQ ID NO 43, SEQ ID NO 77, SEQ ID NO 44, SEQ ID NO 78, SEQ ID NO 45, SEQ ID NO 79, SEQ ID NO 46, SEQ ID NO 80, SEQ ID NO 199, SEQ ID NO 210, SEQ ID NO 200, SEQ ID NO 211, SEQ ID NO 201, SEQ ID NO 212, SEQ ID NO 206, SEQ ID NO 217, SEQ ID NO 207, SEQ ID NO 218, SEQ ID NO 208, SEQ ID NO 219, SEQ ID NO 209, SEQ ID NO 220, SEQ ID NO 232, SEQ ID NO 238, SEQ ID NO 233, SEQ ID NO 239, SEQ ID NO 234, SEQ ID NO 240, SEQ ID NO 237 and SEQ ID NO 243. Typically, these SODs retain at least 70% of their activity under gastric stability studies, when measured according to the test method described in Example 10. 
     In a more preferred embodiment, the fungal SOD of the invention retains at least 80% of its activity under gastric stability studies. Accordingly, in more preferred embodiment, the polypeptide having superoxide dismutase activity may be selected a polypeptide having at least 80% sequence identity, such as at least 85% sequence identity, such as at least 90% sequence identity, such as at least 95% sequence identity, such as at least 98% sequence identity, such as at least 99% sequence identity of a polypeptide selected from the group consisting of SEQ ID NO 1, SEQ ID NO 83, SEQ ID NO 11, SEQ ID NO 12, SEQ ID NO 52, SEQ ID NO 13, SEQ ID NO 53, SEQ ID NO 14, SEQ ID NO 54, SEQ ID NO 15, SEQ ID NO 55, SEQ ID NO 16, SEQ ID NO 56, SEQ ID NO 17, SEQ ID NO 18, SEQ ID NO 20, SEQ ID NO 58, SEQ ID NO 22, SEQ ID NO 60, SEQ ID NO 26, SEQ ID NO 64, SEQ ID NO 28, SEQ ID NO 66, SEQ ID NO 29, SEQ ID NO 67, SEQ ID NO 30, SEQ ID NO 68, SEQ ID NO 31, SEQ ID NO 69, SEQ ID NO 32, SEQ ID NO 70, SEQ ID NO 33, SEQ ID NO 71, SEQ ID NO 34, SEQ ID NO 35, SEQ ID NO 36, SEQ ID NO 37, SEQ ID NO 38, SEQ ID NO 72, SEQ ID NO 39, SEQ ID NO 73, SEQ ID NO 40, SEQ ID NO 74, SEQ ID NO 41, SEQ ID NO 75, SEQ ID NO 42, SEQ ID NO 76, SEQ ID NO 43, SEQ ID NO 77, SEQ ID NO 44, SEQ ID NO 78, SEQ ID NO 45, SEQ ID NO 79, SEQ ID NO 46, SEQ ID NO 80, SEQ ID NO 199, SEQ ID NO 210, SEQ ID NO 206, SEQ ID NO 217, SEQ ID NO 208, SEQ ID NO 219, SEQ ID NO 209, SEQ ID NO 220, SEQ ID NO 232, SEQ ID NO 238, SEQ ID NO 233, SEQ ID NO 239, SEQ ID NO 234 and SEQ ID NO 240. Typically, these SODs retain at least 80% of their activity under gastric stability studies, when measured according to the test method described in Example 10. 
     In a combination of preferred embodiments, the superoxide dismutase is of fungal origin, and preferably has an activity of at least 1500 U/mg at pH 7.8 and is gastric stable such that it retains at least 70% of its activity under the gastric stability test. In an alternative combination of preferred embodiments, the superoxide dismutase is of fungal origin, and preferably has an activity of at least 5000 U/mg at pH 7.8 and is gastric stable such that it retains at least 20% of its activity under the gastric stability test. 
     Preferred polypeptide of fungal origin having superoxide dismutase activity have at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to polypeptides selected from the group consisting of SEQ ID NO 1, SEQ ID NO 83, SEQ ID NO 32, SEQ ID NO 70, SEQ ID NO 42, SEQ ID NO 76, SEQ ID NO 44, SEQ ID NO 78, SEQ ID NO 46, SEQ ID NO 80, SEQ ID NO 202 and SEQ ID NO 213. 
     Thermal Stability of Superoxide Dismutase 
     The commercially available  E. coli  and bovine SODs are tested at 25° C. and stored at −20° C. An animal feed additive for use in animal feed is prepared by a pelleting process, transported by land or sea, stored, and consumed by animals with body temperatures over 30° C. and at gastric pH conditions. Transport and pelleting may lead to temperatures reaching 45° C. Accordingly, thermal stability in each of these conditions is highly pertinent for use of a super oxide dismutase in an animal feed additive. 
     Test were performed on the super oxide dismutases of the invention to measure the temperature at different acidity/alkalinity to determine the temperature at which the polypeptide unfolds and denatures. As can be seen, from the “Thermal Stability Table with pH”, unfolding of the fungal superoxide dismutase takes place at over 45° C., as measured by the Tm, for all fungal superoxide dismutases at neutral pH (pH7). A further embodiment is directed to an animal feed additive comprising a fungal superoxide dismutase thermally stable at pH 7, when measured according to the method described in Example 11, such that protein unfolding (Tm) is 45° C. or more. 
     At gastric pH (pH 3), fungal superoxide dismutases have been found to be stable at normal body temperatures for farm animals. A further embodiment of the invention is directed to an animal feed additive comprising a fungal superoxide dismutase thermally stable at pH 3, when measured according to the method described in Example 11, such that protein unfolding (Tm) is 35° C. or more, such as 40° C. or more, such as 45° C. or more. 
     In a preferred embodiment, the animal feed additive of the invention is thermal stable, when measured according to the method described in Example 11. The commercially available superoxide dismutase from bovine erythrocytes and expressed in  E. coli  of sequence A: 
                    MATKAVCVLKGDGPVQGTIHFEAKGDTVVVTGSITGLTEGDHGFHVHQFG               DNTQGCTSAGPHFNPLSKKHGGPKDEERHVGDLGNVTADKNGVAIVDIVD               PLISLSGEYSIIGRTMVVHEKPDDLGRGGNEESTKTGNAGSRLACGVIGI               AK            
retains very little of its activity at 50° C.
 
     Accordingly, one aspect of the invention is directed to an animal feed additive comprising a fungal superoxide dismutase wherein the superoxide dismutase is thermal stable such that it retains at least 40% of its activity when measured at 50° C. according to the test method described in Example 11, such as retaining at least 50% activity, such as retaining at least 55% activity, such as retaining at least 60% activity, such as retaining at least 65% activity, such as retaining at least 70% activity, such as retaining at least 75% activity, such as retaining at least 80% activity. 
     
       
         
           
               
            
               
                   
               
               
                 Thermal Stability Table at different pH - Tm (unfolding temperature) 
               
            
           
           
               
               
               
            
               
                 SEQ ID 
                 SEQ ID 
                 T m /pH 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 NO 
                 NO 
                 3 
                 4 
                 5 
                 6 
                 7 
                 8 
                 9 
                 10 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 SED ID 
                 SEQ ID 
                 67.1 
                 75.0 
                 75.5 
                 75.4 
                 63.6 
                 63.0 
                 61.2 
                 59.4 
               
               
                 NO 1 
                 NO 83 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 na 
                 56.7 
                 63.4 
                 67.9 
                 66.6 
                 64.8 
                 69.2 
               
               
                 NO 9 
                 NO 49 
               
               
                 SEQ ID 
                 SEQ ID 
                 46.6 
                 54.3 
                 55.5 
                 56.9 
                 56.7 
                 53.4 
                 48.9 
                 44.1 
               
               
                 NO 10 
                 NO 50 
               
               
                 SEQ ID 
                 SEQ ID 
                 44.6 
                 56.7 
                 61.9 
                 61.2 
                 56.6 
                 54.0 
                 50.5 
                 45.8 
               
               
                 NO 11 
                 NO 51 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 43.0 
                 48.0 
                 48.8 
                 48.1 
                 47.0 
                 46.2 
                 45.3 
               
               
                 NO 12 
                 NO 52 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 45.2 
                 49.6 
                 50.1 
                 49.3 
                 48.4 
                 47.3 
                 na 
               
               
                 NO 13 
                 NO 53 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 na 
                 na 
                 na 
                 na 
                 55.5 
                 54.4 
                 53.2 
               
               
                 NO 14 
                 NO 54 
               
               
                 SEQ ID 
                 SEQ ID 
                 52.9 
                 63.0 
                 64.6 
                 59.1 
                 53.6 
                 51.7 
                 50.7 
                 49.7 
               
               
                 NO 15 
                 NO 55 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 37.6 
                 48.7 
                 54.3 
                 55.0 
                 55.6 
                 54.6 
                 53.7 
               
               
                 NO 16 
                 NO 56 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 37.9 
                 48.4 
                 53.6 
                 53.7 
                 54.3 
                 53.3 
                 53.0 
               
               
                 NO 17 
                 NO 18 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 na 
                 Na 
                 66.3 
                 70.7 
                 70.6 
                 71.1 
                 71.6 
               
               
                 NO 19 
                 NO 57 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 na 
                 50.9 
                 61.8 
                 63.5 
                 61.1 
                 59.8 
                 51.8 
               
               
                 NO 21 
                 NO 59 
               
               
                 SEQ ID 
                 SEQ ID 
                 43.7 
                 53.3 
                 59.3 
                 59.3 
                 58.1 
                 62.1 
                 57.7 
                 51.1 
               
               
                 NO 22 
                 NO 60 
               
               
                 SEQ ID 
                 SEQ ID 
                 43.3 
                 51.9 
                 58.8 
                 59.5 
                 57.6 
                 53.9 
                 52.8 
                 50.6 
               
               
                 NO 23 
                 NO 61 
               
               
                 SEQ ID 
                 SEQ ID 
                 43.9 
                 52.3 
                 59.2 
                 63.7 
                 62.3 
                 61.8 
                 59.9 
                 59.2 
               
               
                 NO 24 
                 NO 62 
               
               
                 SEQ ID 
                 SEQ ID 
                 40.6 
                 49.2 
                 58.1 
                 62.8 
                 62.1 
                 54.7 
                 54.2 
                 60.8 
               
               
                 NO 25 
                 NO 63 
               
               
                 SEQ ID 
                 SEQ ID 
                 50.9 
                 64.6 
                 68.4 
                 73.4 
                 74.9 
                 74.2 
                 73.9 
                 72.8 
               
               
                 NO 27 
                 NO 65 
               
               
                 SEQ ID 
                 SEQ ID 
                 62.0 
                 72.3 
                 74.6 
                 74.5 
                 71.9 
                 63.8 
                 58.3 
                 56.0 
               
               
                 NO 28 
                 NO 66 
               
               
                 SEQ ID 
                 SEQ ID 
                 63.7 
                 71.0 
                 73.0 
                 72.9 
                 70.6 
                 62.5 
                 57.2 
                 55.7 
               
               
                 NO 29 
                 NO 67 
               
               
                 SEQ ID 
                 SEQ ID 
                 62.8 
                 71.3 
                 73.2 
                 73.2 
                 71.3 
                 63.9 
                 57.4 
                 55.3 
               
               
                 NO 30 
                 NO 68 
               
               
                 SEQ ID 
                 SEQ ID 
                 74.5 
                 78.7 
                 78.5 
                 76.1 
                 70.4 
                 64.6 
                 58.6 
                 46.8 
               
               
                 NO 31 
                 NO 69 
               
               
                 SEQ ID 
                 SEQ ID 
                 54.3 
                 66.7 
                 65.2 
                 71.6 
                 72.5 
                 69.7 
                 62.2 
                 54.6 
               
               
                 NO 32 
                 NO 70 
               
               
                 SEQ ID 
                 SEQ ID 
                 54.9 
                 63.0 
                 68.2 
                 68.2 
                 66.7 
                 64.1 
                 62.8 
                 61.8 
               
               
                 NO 33 
                 NO 71 
               
               
                 SEQ ID 
                 SEQ ID 
                 67.1 
                 75.5 
                 77.0 
                 76.4 
                 73.6 
                 66.5 
                 60.7 
                 58.3 
               
               
                 NO 34 
                 NO 35 
               
               
                 SEQ ID 
                 SEQ ID 
                 58.8 
                 60.9 
                 59.9 
                 65.2 
                 66.5 
                 63.6 
                 56.3 
                 54.4 
               
               
                 NO 36 
                 NO 37 
               
               
                 SEQ ID 
                 SEQ ID 
                 60.5 
                 71.0 
                 72.8 
                 72.7 
                 71.3 
                 60.9 
                 57.6 
                 55.3 
               
               
                 NO 38 
                 NO 72 
               
               
                 SEQ ID 
                 SEQ ID 
                 68.0 
                 76.2 
                 76.9 
                 76.2 
                 73.7 
                 65.0 
                 60.6 
                 58.1 
               
               
                 NO 39 
                 NO 73 
               
               
                 SEQ ID 
                 SEQ ID 
                 52.8 
                 67.6 
                 74.7 
                 74.2 
                 69.2 
                 55.9 
                 54.1 
                 51.9 
               
               
                 NO 40 
                 NO 74 
               
               
                 SEQ ID 
                 SEQ ID 
                 53.3 
                 68.3 
                 75.1 
                 77.9 
                 75.3 
                 64.8 
                 59.7 
                 56.5 
               
               
                 NO 41 
                 NO 75 
               
               
                 SEQ ID 
                 SEQ ID 
                 47.8 
                 58.4 
                 62.8 
                 64.3 
                 64.0 
                 59.4 
                 54.7 
                 50.3 
               
               
                 NO 42 
                 NO 76 
               
               
                 SEQ ID 
                 SEQ ID 
                 49.5 
                 52.9 
                 58.5 
                 60.3 
                 59.0 
                 57.0 
                 52.8 
                 49.8 
               
               
                 NO 43 
                 NO 77 
               
               
                 SEQ ID 
                 SEQ ID 
                 51.8 
                 67.7 
                 74.2 
                 76.8 
                 77.2 
                 83.7 
                 77.6 
                 65.8 
               
               
                 NO 44 
                 NO 78 
               
               
                 SEQ ID 
                 SEQ ID 
                 52.5 
                 56.4 
                 63.3 
                 65.8 
                 58.9 
                 61.4 
                 53.5 
                 50.1 
               
               
                 NO 45 
                 NO 79 
               
               
                 SEQ ID 
                 SEQ ID 
                 75.3 
                 86.5 
                 &gt;95   
                 &gt;95   
                 &gt;95 
                 91.1 
                 88.9 
                 86.8 
               
               
                 NO 46 
                 NO 80 
               
               
                 SEQ ID 
                 SEQ ID 
                 46.5 
                 57.9 
                 62.0 
                 61.5 
                 57.8 
                 56.1 
                 52.1 
                 51.6 
               
               
                 NO 47 
                 NO 81 
               
               
                 SEQ ID 
                 SEQ ID 
                 53.5 
                 58.4 
                 64.3 
                 65.8 
                 63.3 
                 59.5 
                 49.4 
                 43.4 
               
               
                 NO 48 
                 NO 82 
               
               
                 SEQ ID 
                 SEQ ID 
                 48.9 
                 na 
                 na 
                 58.8 
                 58.4 
                 na 
                 53.5 
                 48 
               
               
                 NO 199 
                 NO 210 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 61.1 
                 na 
                 na 
                 57.1 
                 54.9 
                 na 
                 47.5 
               
               
                 NO 200 
                 NO 211 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 na 
                 na 
                 56.9 
                 55.5 
                 53.5 
                 51.9 
                 49.6 
               
               
                 NO 201 
                 NO 212 
               
               
                 SEQ ID 
                 SEQ ID 
                 56.7 
                 69.4 
                 59.9 
                 62   
                 64.8 
                 64.7 
                 63.4 
                 56.5 
               
               
                 NO 202 
                 NO 213 
               
               
                 SEQ ID 
                 SEQ ID 
                 55.3 
                 na 
                 63.9 
                 na 
                 58.2 
                 55.1 
                 52.6 
                 46 
               
               
                 NO 203 
                 NO 214 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 na 
                 59.4 
                 60   
                 na 
                 na 
                 na 
                 49.2 
               
               
                 NO 204 
                 NO 215 
               
               
                 SEQ ID 
                 SEQ ID 
                 57.3 
                 66.6 
                 68.8 
                 68.2 
                 64.3 
                 57   
                 54.1 
                 51.8 
               
               
                 NO 205 
                 NO 216 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 na 
                 na 
                 na 
                 65.7 
                 63.6 
                 51.2 
                 45.2 
               
               
                 NO 206 
                 NO 217 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 72.4 
                 81.2 
                 84.8 
                 86.1 
                 86.3 
                 86.1 
                 85.4 
               
               
                 NO 207 
                 NO 218 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 70.5 
                 80.1 
                 83.1 
                 85 
                 85.4 
                 85.5 
                 84.5 
               
               
                 NO 208 
                 NO 219 
               
               
                 SEQ ID 
                 SEQ ID 
                 na 
                 72.9 
                 81.7 
                 84.8 
                 86.1 
                 86.6 
                 86.3 
                 85.6 
               
               
                 NO 209 
                 NO 220 
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 Bovine SOD S9697 
                 50.8 
                 59.3 
                 63.9 
                 66.2 
                 65.2 
                 63.1 
                 61.0 
                 57.0 
               
               
                 SIGMA 
               
               
                   
               
            
           
         
       
     
     Catalases 
     In a preferred embodiment, the method of the invention, the animal feed additive of the invention and the animal feed of the invention further comprise a polypeptide having catalase activity. The catalase from Bovine Liver (Enzyme Commission (EC) Number: 1.11.1.6, CAS Number: 9001-05-2, Molecular weight: 250 kDa) has an activity of 3524 U/mg EP and a gastric stability wherein it retains only 40% of its activity under the gastric stability studies. 
     The catalase of the invention is of bacterial origin or of fungal origin, preferably of fungal origin. The catalases of the invention have shown to be either highly active, highly gastric stable or highly thermal stable, or combinations thereof. 
     Sequences of Catalases 
     In a preferred embodiment, the method of the invention, the animal feed additive of the invention and the animal feed of the invention further comprise a polypeptide having catalase activity. 
     Typically, the polypeptide having catalase activity is selected from the group consisting of:
         a. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 6; and   b. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 7   c. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 103   d. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 104;   e. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 105;   f. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 106;   g. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 107;   h. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 108;   i. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 109   j. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 110   k. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 111   l. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 112   m. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 113   n. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 114   o. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 115   p. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 116   q. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 117   r. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 118   s. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 119   t. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 120   u. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 121   v. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 122   w. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 123   x. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 124   y. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 125   z. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 126;   aa. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 250;   bb. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 151;   cc. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 152;   dd. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 153;   ee. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 154;   ff. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 155;   gg. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 156;   hh. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 157;   ii. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 158;   jj. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 159;   kk. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 160;   ll. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 161;   mm. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 162;   nn. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 163;   oo. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 164;   pp. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 165;   qq. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 166;   rr. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 167;   ss. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 168;   tt. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 169;   uu. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 170;   vv. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 171;   ww. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 172;   xx. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 173;   yy. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 174;   zz. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 250; and   aaa. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 251.       

     In a preferred embodiment, the polypeptide having catalase activity is selected from the group consisting of: 
     a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 6; 
     a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 7; 
     a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 250; and 
     a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 251. 
     Sources of Catalases 
     SEQ ID NO 6 and SEQ ID NO 7 are polypeptide having catalase activity available from  Aspergillus niger . SEQ ID NO 7 is sold under the tradename Catazyme™. SEQ ID NO: 103 is a polypeptide having catalase activity available from  Thermoascus aurantiacus . SEQ ID NO: 104 is a polypeptide having catalase activity available from  Aspergillus lentulus . SEQ ID NO: 105 is a polypeptide having catalase activity available from  Talaromyces stipitatus . SEQ ID NO: 106 is a polypeptide having catalase activity available from  Malbranchea cinnamomea . SEQ ID NO: 107 is a polypeptide having catalase activity available from  Crassicarpon thermophilum . SEQ ID NO: 108 is a polypeptide having catalase activity available from  Penicillium emersonii . SEQ ID NO: 109 is a polypeptide having catalase activity available from  Aspergillus versicolor . SEQ ID NO: 110 is a polypeptide having catalase activity available from  Thermomucor indicae - seudaticae . SEQ ID NO: 111 is a polypeptide having catalase activity available from  Aspergillus fumigatus . SEQ ID NO: 112 is a polypeptide having catalase activity available from  Thermothelomyces thermophilus . SEQ ID NO: 113 is a polypeptide having catalase activity available from  Curvularia verruculosa . SEQ ID NO: 114 is a polypeptide having catalase activity available from  Mycothermus thermophilus . SEQ ID NO: 115 is a polypeptide having catalase activity available from  Mycothermus thermophilus . SEQ ID NO: 116 is a polypeptide having catalase activity available from  Penicillium oxalicum . SEQ ID NO: 117 is a polypeptide having catalase activity available from  Humicola hyalothermophila . SEQ ID NO: 118 is a polypeptide having catalase activity available from  Thermoascus crustaceus . SEQ ID NO: 119 is a polypeptide having catalase activity available from  Thielavia australiensis . SEQ ID NO: 120 is a polypeptide having catalase activity available from  Thielavia hyrcaniae . SEQ ID NO: 121 is a polypeptide having catalase activity available from  Neurospora crassa . SEQ ID NO: 122 is a polypeptide having catalase activity available from  Thermoascus aurantiacus . SEQ ID NO: 123 is a polypeptide having catalase activity available from  Neurospora crassa . SEQ ID NO: 124 is a polypeptide having catalase activity available from  Thermoascus aurantiacus . SEQ ID NO: 125 is a polypeptide having catalase activity available from  Thermoascus aurantiacus . SEQ ID NO: 126 is a polypeptide having catalase activity available from  Thermoascus aurantiacus.    
     Accordingly, the catalase of the invention may be selected from a polypeptide having catalase activity and obtained from, obtainable from, or derivable from a source selected from the group consisting of  Aspergillus niger, Thermoascus aurantiacus, Aspergillus lentulus, Scytalidium thermophilum, Talaromyces stipitatus, Malbranchea cinnamomea, Crassicarpon thermophilum, Penicillium emersonii, Aspergillus versicolor, Thermomucor indicae - seudaticae, Aspergillus fumigatus, Thermothelomyces thermophilus, Curvularia verruculosa, Mycothermus thermophilus, Penicillium oxalicum, Humicola hyalothermophila, Thermoascus crustaceus, Thielavia australiensis, Thielavia hyrcaniae  and  Neurospora crassa.    
     In a preferred embodiment, the catalase is selected from the group consisting of a catalase obtained from, obtainable from, or derivable from a source selected from the group consisting of  Aspergillus niger, Scytalidium thermophilum  and  Thermoascus aurantiacus , more preferably from  Aspergillus niger  and  Thermoascus aurantiacus    
     Activity of Catalases 
     The catalase from Bovine Liver (Enzyme Commission (EC) Number: 1.11.1.6 CAS Number: 9001-05-2, Molecular weight: 250 kDa) has an activity of 3524 U/mg EP and a gastric stability wherein it retains only 40% of its activity under the gastric stability studies of Example 12. 
     In a preferred embodiment, the catalase of the invention has an activity level above 5000 U/mg EP when measured according to the method described in Example 11 and/or at pH 7.8. Accordingly, in one embodiment of the invention the catalase is selected from a polypeptide which has at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity with a mature polypeptide selected from the group consisting of SEQ ID NO 250, SEQ ID NO 7, SEQ ID NO 105, SEQ ID NO 108, SEQ ID NO 116, SEQ ID NO 118, SEQ ID NO 112, SEQ ID NO 113, SEQ ID NO 115, SEQ ID NO 104, SEQ ID NO 111, SEQ ID NO 123, SEQ ID NO 121, SEQ ID NO 106, SEQ ID NO 117, SEQ ID NO 119, SEQ ID NO 110, SEQ ID NO 107 or with a full length polypeptide selected from the group consisting of SEQ ID NO 251, SEQ ID NO 8, SEQ ID NO 153, SEQ ID NO 156, SEQ ID NO 164, SEQ ID NO 166, SEQ ID NO 160, SEQ ID NO 161, SEQ ID NO 163, SEQ ID NO 152, SEQ ID NO 159, SEQ ID NO 171, SEQ ID NO 169, SEQ ID NO 154, SEQ ID NO 165, SEQ ID NO 167, SEQ ID NO 158, and SEQ ID NO 155. 
     
       
         
           
               
               
               
               
             
               
                   
               
               
                   
                 Mature 
                 Full length 
                   
               
               
                 Source 
                 Polypeptide 
                 polypeptide 
                 Activity 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Talaromyces stipitatus 
                 SEQ ID NO 105 
                 SEQ ID NO 153 
                 1667 
               
               
                 Penicillium emersonii 
                 SEQ ID NO 108 
                 SEQ ID NO 156 
                 8265 
               
               
                 Penicillium oxalicum 
                 SEQ ID NO 116 
                 SEQ ID NO 164 
                 30953 
               
               
                 Thermoascus crustaceus 
                 SEQ ID NO 118 
                 SEQ ID NO 166 
                 10919 
               
               
                 Thermothelomyces thermophilus 
                 SEQ ID NO 112 
                 SEQ ID NO 160 
                 18314 
               
               
                 Curvularia verruculosa 
                 SEQ ID NO 113 
                 SEQ ID NO 161 
                 20836 
               
               
                   Aspergillus oryzae  (NN051131) 
                 SEQ ID NO 115 
                 SEQ ID NO 163 
                 43975 
               
               
                 
                   Aspergillus lentulus 
                 
                 SEQ ID NO 104 
                 SEQ ID NO 152 
                 52327 
               
               
                 
                   Aspergillus fumigatus 
                 
                 SEQ ID NO 111 
                 SEQ ID NO 159 
                 51648 
               
               
                 Neurospora crassa 
                 SEQ ID NO 123 
                 SEQ ID NO 171 
                 8651 
               
               
                 Neurospora crassa 
                 SEQ ID NO 121 
                 SEQ ID NO 169 
                 51184 
               
               
                 Malbranchea cinnamomea 
                 SEQ ID NO 106 
                 SEQ ID NO 154 
                 82637 
               
               
                 
                   Humicola hyalothermophila 
                 
                 SEQ ID NO 117 
                 SEQ ID NO 165 
                 56454 
               
               
                 Thielavia australiensis 
                 SEQ ID NO 119 
                 SEQ ID NO 167 
                 5273 
               
               
                 Thermomucor indicae-seudaticae 
                 SEQ ID NO 110 
                 SEQ ID NO 158 
                 7750 
               
               
                 Crassicarpon thermophilum 
                 SEQ ID NO 107 
                 SEQ ID NO 155 
                 39459 
               
               
                   
               
            
           
         
       
     
     Thermal Stability of Catalases 
     An aspect of the invention is directed to an animal feed additive comprising a catalase wherein the catalase is thermal stable such that it retains at least 40% of its activity when measured at 50° C. and pH 7 such as retaining at least 50% activity, such as retaining at least 55% activity, such as retaining at least 60% activity, such as retaining at least 65% activity, such as retaining at least 70% activity, such as retaining at least 75% activity, such as retaining at least 80% activity. 
     An aspect of the invention is directed to an animal feed additive comprising a catalase wherein the catalase is thermal stable such that it retains at least 50% of its activity when measured at 40° C. at pH 7 such as retaining at least 55% activity, such as retaining at least 60% activity, such as retaining at least 65% activity, such as retaining at least 70% activity, such as retaining at least 75% activity, such as retaining at least 80% activity. 
     
       
         
           
               
            
               
                   
               
               
                 Thermal Stability at different pHs 
               
            
           
           
               
               
               
               
            
               
                   
                 Mature 
                 T m   
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 Source 
                 SEQ ID NO 
                 3 
                 4 
                 5 
                 6 
                 7 
                 8 
                 9 
                 10 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 
                   Thermoascus 
                 
                 SEQ ID 
                 58.5 
                 70.2 
                 80.1 
                 82.1 
                 84.0 
                 83.8 
                 77.9 
                 79.9 
               
               
                 
                   aurantiacus 
                 
                 NO 250 
               
               
                 
                   Aspergillus 
                 
                 SEQ ID 
                 56.0 
                 68.2 
                 72.2 
                 72.3 
                 70.2 
                 67.0 
                 65.7 
                 66.1 
               
               
                 
                   niger 
                 
                 NO 7 
               
               
                 
                   Thermoascus 
                 
                 SEQ ID 
                 67.1 
                 75.7 
                 79.9 
                 80.7 
                 79.7 
                 79.9 
                 78.8 
                 71.0 
               
               
                 
                   aurantiacus 
                 
                 NO 251 
               
               
                 
                   Talaromyces 
                 
                 SEQ ID 
                 na 
                 na 
                 na 
                 na 
                 41.8 
                 41.9 
                 42.6 
                 42.6 
               
               
                 
                   stipitatus 
                 
                 NO 105 
               
               
                 
                   Penicillium 
                 
                 SEQ ID 
                 na 
                 na 
                 na 
                 45.3 
                 50.4 
                 50.4 
                 50.2 
                 50.0 
               
               
                 
                   emersonii 
                 
                 NO 108 
               
               
                 
                   Penicillium 
                 
                 SEQ ID 
                 na 
                 51.9 
                 59.6 
                 63.6 
                 73.8 
                 65.7 
                 63.1 
                 57.1 
               
               
                 
                   oxalicum 
                 
                 NO 116 
               
               
                 
                   Thermoascus 
                 
                 SEQ ID 
                 52.8 
                 57.7 
                 59.7 
                 59.2 
                 55.4 
                 53.7 
                 53.1 
                 52.3 
               
               
                 
                   crustaceus 
                 
                 NO 118 
               
               
                 
                   Thermothelomyces 
                 
                 SEQ ID 
                 na 
                 na 
                 na 
                 na 
                 na 
                 60.1 
                 60.6 
                 na 
               
               
                 
                   thermophilus 
                 
                 NO 112 
               
               
                 
                   Scytalidium 
                 
                 Note A 
                 78.3 
                 &gt;95   
                 &gt;95   
                 &gt;95   
                 &gt;95   
                 89.8 
                 86.0 
                 78.7 
               
               
                 
                   thermophilum 
                 
               
               
                 Curvularia 
                 SEQ ID 
                 44.8 
                 57.3 
                 60.4 
                 59.8 
                 57.8 
                 57 
                 54.2 
                 49.1 
               
               
                 verruculosa 
                 NO 113 
               
               
                 
                   Aspergillus 
                 
                 SEQ ID 
                 na 
                 na 
                 60.3 
                 61.7 
                 63   
                 na 
                 62.1 
                 55.3 
               
               
                 
                   oryzae 
                 
                 NO 115 
               
               
                 
                   Aspergillus 
                 
                 SEQ ID 
                 na 
                 66.5 
                 na 
                 na 
                 85.1 
                 na 
                 72.6 
                 73.4 
               
               
                 
                   lentulus 
                 
                 NO 104 
               
               
                 
                   Aspergillus 
                 
                 SEQ ID 
                 na 
                 na 
                 na 
                 na 
                 83.7 
                 82.1 
                 78.6 
                 73.1 
               
               
                 
                   fumigatus 
                 
                 NO 111 
               
               
                 
                   Neurospora 
                 
                 SEQ ID 
                 na 
                 na 
                 na 
                 na 
                 67.6 
                 61.5 
                 61.7 
                 na 
               
               
                 
                   crassa 
                 
                 NO 123 
               
               
                 
                   Neurospora 
                 
                 SEQ ID 
                 na 
                 na 
                 na 
                  9.5 
                 81.8 
                 81.2 
                 80.5 
                 na 
               
               
                 
                   crassa 
                 
                 NO 121 
               
               
                 Malbranchea 
                 SEQ ID 
                 na 
                 na 
                 69.7 
                 77.3 
                 84.2 
                 85 
                 85.2 
                 na 
               
               
                 cinnamomea 
                 NO 106 
               
               
                 
                   Humicola 
                 
                 SEQ ID 
                 na 
                 na 
                  6.8 
                 na 
                 na 
                 na 
                 89.2 
                 83.6 
               
               
                 
                   hyalothermophila 
                 
                 NO 117 
               
               
                 
                   Thielavia 
                 
                 SEQ ID 
                 na 
                 na 
                 na 
                 47.4 
                 64.3 
                 57 
                 52.1 
                 45.2 
               
               
                 
                   australiensis 
                 
                 NO 119 
               
               
                 
                   Crassicarpon 
                 
                 SEQ ID 
                 na 
                 na 
                 na 
                 na 
                 na 
                 85.3 
                 83.3 
                 73.4 
               
               
                 
                   thermophilum 
                 
                 NO 107 
               
               
                   
               
               
                 Note A: 
               
               
                 SEQ ID NO: 2 of U.S. Pat. No. 5,646,025 
               
            
           
         
       
     
     An aspect of the invention is directed to an animal feed additive comprising a catalase wherein the catalase is thermal stable such that it retains at least 50% of its activity when measured at 50° C. and pH 5 such as retaining at least 55% activity, such as retaining at least 60% activity, such as retaining least 65% activity, such as retaining at least 70% activity, such as retaining at least 75% activity, such as retaining at least 80% activity. An aspect of the invention is directed to an animal feed additive comprising a catalase wherein the catalase is thermal stable such that its Tm is at least 50° C. at pH 5. 
     An aspect of the invention is directed to an animal feed additive comprising a catalase wherein the catalase is thermal stable such that it retains at least 50% of its activity when measured at 50° C. and pH 4 such as retaining at least 55% activity, such as retaining at least 60% activity, such as retaining least 65% activity, such as retaining at least 70% activity, such as retaining at least 75% activity, such as retaining at least 80% activity. An aspect of the invention is directed to an animal feed additive comprising a catalase wherein the catalase is thermal stable such that its Tm is at least 50° C. at pH 4. 
     An aspect of the invention is directed to an animal feed additive comprising a catalase wherein the catalase is thermal stable such that it retains at least 50% of its activity when measured at 40° C. and pH 3 such as retaining at least 55% activity, such as retaining at least 60% activity, such as retaining least 65% activity, such as retaining at least 70% activity, such as retaining at least 75% activity, such as retaining at least 80% activity. An aspect of the invention is directed to an animal feed additive comprising a catalase wherein the catalase is thermal stable such that its Tm is at least 40° C. at pH 3. 
     Gastric Stability of Catalases 
     The catalase from Bovine Liver (Enzyme Commission (EC) Number: 1.11.1.6 CAS Number: 9001-05-2, Molecular weight: 250 kDa) has an activity of 3524 U/mg EP and a gastric stability wherein it retains only 40% of its activity under the gastric stability studies of Example 12. 
     One aspect of the invention is directed to an animal feed additive further comprising a catalase wherein the catalase is gastric stable such that it retains at least 40% of its activity when measured according to the test method described in Example 12, such as retaining at least 50% activity, such as retaining at least 55% activity, such as retaining at least 60% activity, such as retaining at least 65% activity, such as retaining at least 70% activity, such as retaining at least 75% activity, such as retaining at least 80% activity. As can be seen from the Table in Example 12, each of SEQ ID NO 109, SEQ ID NO 126, SEQ ID NO 7, (SEQ ID NO 250), SEQ ID NO 105, SEQ ID NO 108, SEQ ID NO 116, SEQ ID NO 105, SEQ ID NO 112, SEQ ID NO 115, SEQ ID NO 104, SEQ ID NO 117, SEQ ID NO 107, SEQ ID NO 110, SEQ ID NO 123 retain at least 50% of their activity at pH 3 and exposure to pepsin. 
     Animal Feed Additive and Animal Feed 
     The invention is directed to an animal feed additive and to an animal feed comprising the animal feed additive as defined herein. An aspect of the invention is directed to an animal feed additive comprising a polypeptide of fungal origin having superoxide dismutase activity. The animal feed additive may further comprising a catalase. The animal feed additive may alternatively be defined as comprising an enzyme component, wherein the enzyme component comprises all of the enzymes of the additive and the enzyme component consists of a superoxide dismutase of fungal origin and optionally of a catalase. In a further aspect, the invention is directed to an animal feed additive comprising at least one and no more than two enzyme classes, wherein the at least one enzyme class is a superoxide dismutase of fungal origin and the optional second enzyme class is a catalase. 
     In an embodiment, the animal feed additive is wherein the polypeptide having superoxide dismutase activity is selected from the group consisting of:
         a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 1;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 2;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 3;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 4;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 9;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 10;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 11;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 12;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 13;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 14;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 15;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 16;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 17;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 19;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 20;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 21;   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 22;   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 23;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 24;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 25;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 26;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 27;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 28;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 29;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 30;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 31;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 32;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 33;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 34;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 36;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 38;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 39;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 42;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 43;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 44;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 45;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 46;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 47; and   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 48;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:199;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:200;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 201;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:202;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:203;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:204;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 205;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:206;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:207;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:208;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:209;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:232;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:233;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:234;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:235;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:236; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:237.       

     In an embodiment, the animal feed additive is wherein the polypeptide having superoxide dismutase activity is selected from the group consisting of:
         a. a polypeptide  Trichoderma reesei  from having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 1;   b. a polypeptide from  Aspergillus versicolor  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 2;   c. a polypeptide from  Aspergillus deflectus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 3;   d. a polypeptide from  Aspergillus egyptiacus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 4;   e. a polypeptide from  Westerdykella  sp. AS85-2 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 9;   f. a polypeptide from  Aspergillus  sp. XZ2669 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 10;   g. a polypeptide from  Preussia terricola  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 11;   h. a polypeptide from  Kionochaeta  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 12;   i. a polypeptide from  Kionochaeta  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 13;   j. a polypeptide from  Metapochonia bulbillosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 14;   k. a polypeptide from  Xylomelasma  sp. XZ0718 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 15;   l. a polypeptide from  Preussia flanaganii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 16;   m. a polypeptide from  Cladobotryum  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 17;   n. a polypeptide from  Westerdykella  sp-46156 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 19;   o. a polypeptide from  Trichoderma hamatum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 20;   p. a polypeptide from  Mycothermus thermophilus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 21;   q. a polypeptide from  Cephalotrichiella penicillata  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 22;   r. a polypeptide from  Chaetomium megalocarpum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 23;   s. a polypeptide from  Chaetomium thermophilum  var.  thermophilum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 24;   t. a polypeptide from  Humicola hyalothermophila  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 25;   u. a polypeptide from  Subramaniula anamorphosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 26;   v. a polypeptide from  Sphingobacterium  sp. T2 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 27;   w. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 28;   x. a polypeptide from  Trichoderma lixii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 29;   y. a polypeptide from  Trichoderma  sp-54723 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 30;   z. a polypeptide from  Aspergillus niveus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 31;   aa. a polypeptide from  Aspergillus templicola  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 32;   bb. a polypeptide from  Pochonia chlamydosporia  var.  spinulospora  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 33;   cc. a polypeptide from  Trichoderma  sp-44174 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 34;   dd. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 36;   ee. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 38;   ff. a polypeptide from  Trichoderma  sp-44174 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 39;   gg. a polypeptide from  Metapochonia suchlasporia  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;   hh. a polypeptide from  Metarhizium marquandii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;   ii. a polypeptide from  Diaporthe nobilis  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 42;   jj. a polypeptide from  Tolypocladium  sp. XZ2627 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 43;   kk. a polypeptide from  Aspergillus japonicus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 44;   ll. a polypeptide from  Metarhizium  sp. XZ2431 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 45;   mm. a polypeptide from  Armillaria ostoyae  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 46;   nn. a polypeptide from  Trichoderma spirale  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 47; and   oo. a polypeptide from  Aspergillus elegans  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 48;   pp. a polypeptide from  Trichoderma sinuosum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:199;   qq. a polypeptide from  Trichoderma virens  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:200;   rr. a polypeptide from  Trichoderma harzianum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 201;   ss. a polypeptide from  Fusicolla acetilerea  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:202;   tt. a polypeptide from  Plectosphaerella  sp. 1-29 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:203;   uu. a polypeptide  Mariannaea punicea  from having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:204;   vv. a polypeptide from  Penicillium oxalicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 205;   ww. a polypeptide from  Colletotrichum  sp-71086 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:206;   xx. a polypeptide from  Aspergillus  sp.  nov . XZ3202 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:207;   yy. a polypeptide from  Trichoderma parapiluliferum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:208;   zz. a polypeptide from  Aspergillus  sp.  nov . XZ3202 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:209;   aaa. a polypeptide from  Mucor  sp. XZ2651 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:232;   bbb. a polypeptide from  Rhizomucor miehei  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:233;   ccc. a polypeptide from  Mucor  sp. XZ2651 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:234;   ddd. a polypeptide from Amphisphaeriaceae -sp 43674 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:235;   eee. a polypeptide from  Humicola fuscoatra  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:236; and   fff. a polypeptide from  Valsaria rubricosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:237.       

     In an embodiment, the animal feed additive is wherein the polypeptide having superoxide dismutase activity comprises an amino acid sequence selected from the group consisting of:
         a. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 1;   b. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 2;   c. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 3;   d. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 4;   e. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 9;   f. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 10;   g. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 11;   h. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 12;   i. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 13;   j. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 14;   k. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 15;   l. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 16;   m. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 17;   n. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 19;   o. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 20;   p. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 21;   q. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 22;   r. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 23;   s. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 24;   t. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100 sequence identity to the amino acid sequence of SEQ ID NO: 25;   u. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 26;   v. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 27;   w. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 28;   x. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 29;   y. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 30;   z. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 31;   aa. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 32;   bb. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 33;   cc. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 34;   dd. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 36;   ee. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 38;   ff. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 39;   gg. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;   hh. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;   ii. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 42;   jj. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 43;   kk. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 44;   ll. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 45;   mm. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 46;   nn. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 47; and   oo. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 48;   pp. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:199;   qq. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:200;   rr. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO 201;   ss. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:202;   tt. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:203;   uu. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:204;   vv. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 205;   ww. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:206;   xx. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:207;   yy. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:208;   zz. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:209;   aaa. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:232;   bbb. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:233;   ccc. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:234;   ddd. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:235;   eee. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:236; and   fff. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:237.       

     In an embodiment, the animal feed additive is wherein the polypeptide having superoxide dismutase activity is selected from the group consisting
         a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 83;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 84;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 85;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 86;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 49;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 50;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 51;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 52;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 53;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 54;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 55;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 56;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 18;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 57;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 58;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 59,   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 60,   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 61;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 62;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 63;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 64;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 65;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 66;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 67;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 68;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 69;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 70;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 71;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 35;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 37;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 72;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 73;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 74;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 75;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 76;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 77;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 78;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 79;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 80;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 81;   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 82;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 210;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 211;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 212;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 213;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 214;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 215;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 216;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 217;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 218;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 219;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 220;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 238;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 239;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 240;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 241;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 242; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 243.       

     In an embodiment, the animal feed additive is wherein the polypeptide having superoxide dismutase activity is selected from the group consisting of
         a. a polypeptide from  Trichoderma reesei  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 83;   b. a polypeptide from  Aspergillus versicolor  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 84;   c. a polypeptide from  Aspergillus deflectus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 85;   d. a polypeptide from  Aspergillus egyptiacus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 86;   e. a polypeptide from  Westerdykella  sp. AS85-2 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 49;   f. a polypeptide from  Aspergillus  sp. XZ2669 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 50;   g. a polypeptide from  Preussia terricola  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 51;   h. a polypeptide from  Kionochaeta  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 52;   i. a polypeptide from  Kionochaeta  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 53;   j. a polypeptide from  Metapochonia bulbillosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 54;   k. a polypeptide from  Xylomelasma  sp. XZ0718 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 55;   l. a polypeptide from  Preussia flanaganii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 56;   m. a polypeptide from  Cladobotryum  sp having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 18;   n. a polypeptide from  Westerdykella  sp-46156 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 57;   o. a polypeptide from  Trichoderma hamatum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 58;   p. a polypeptide from  Mycothermus thermophilus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 59,   q. a polypeptide from  Cephalotrichiella penicillata  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 60,   r. a polypeptide from  Chaetomium megalocarpum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 61;   s. a polypeptide from  Chaetomium thermophilum  var.  thermophilum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 62;   t. a polypeptide from  Humicola hyalothermophila  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 63;   u. a polypeptide from  Subramaniula anamorphosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 64;   v. a polypeptide from  Sphingobacterium  sp. T2 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 65;   w. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 66;   x. a polypeptide from  Trichoderma lixii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 67;   y. a polypeptide from  Trichoderma  sp-54723 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 68;   z. a polypeptide from  Aspergillus niveus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 69;   aa. a polypeptide from  Aspergillus templicola  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 70;   bb. a polypeptide from  Pochonia chlamydosporia  var.  spinulospora  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 71;   cc. a polypeptide from  Trichoderma  sp-44174 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 35;   dd. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 37;   ee. a polypeptide from  Trichoderma  sp-54723 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 72;   ff. a polypeptide from  Trichoderma  sp-44174 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 73;   gg. a polypeptide from  Metapochonia suchlasporia  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 74;   hh. a polypeptide from  Metarhizium marquandii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 75;   ii. a polypeptide from  Diaporthe nobilis  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 76;   jj. a polypeptide from  Tolypocladium  sp. XZ2627 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 77;   kk. a polypeptide from  Aspergillus japonicus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 78;   ll. a polypeptide from  Metarhizium  sp. XZ2431 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 79;   mm. a polypeptide from  Armillaria ostoyae  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 80;   nn. a polypeptide from  Trichoderma spirale  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 81;   oo. a polypeptide from  Aspergillus elegans  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 82;   pp. a polypeptide from  Trichoderma sinuosum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 210;   qq. a polypeptide from  Trichoderma virens  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 211;   rr. a polypeptide from  Trichoderma harzianum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 212;   ss. a polypeptide from  Fusicolla acetilerea  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 213;   tt. a polypeptide from  Plectosphaerella  sp. 1-29 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 214;   uu. a polypeptide from  Mariannaea punicea  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 215;   vv. a polypeptide from  Penicillium oxalicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 216;   ww. a polypeptide from  Colletotrichum  sp-71086 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 217;   xx. a polypeptide from  Aspergillus  sp.  nov . XZ3202 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 218;   yy. a polypeptide from  Trichoderma parapiluliferum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 219;   zz. a polypeptide from  Aspergillus  sp.  nov . XZ3202 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 220;   aaa. a polypeptide from  Mucor  sp. XZ2651 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 238;   bbb. a polypeptide from  Rhizomucor miehei  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 239;   ccc. a polypeptide from  Mucor  sp. XZ2651 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 240;   ddd. a polypeptide from Amphisphaeriaceae -sp 43674 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 241;   eee. a polypeptide from  Humicola fuscoatra  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 242; and   fff. a polypeptide from  Valsaria rubricosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 243.       

     The animal feed additive suitably comprises one or more polypeptides of fungal origin having superoxide dismutase (SOD) activity wherein the polypeptide having superoxide dismutase activity is selected from the group consisting of:
         a. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 5;   b. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 87;   c. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 88;   d. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 89;   e. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 90;   f. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 91;   g. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 92;   h. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 93;   i. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 94;   j. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 95;   k. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 96;   l. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 97;   m. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 98;   n. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 99;   o. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 100;   p. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 101;   q. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 102;   r. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 127;   s. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 128;   t. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 129;   u. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 130;   v. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 131;   w. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 132;   x. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 133;   y. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 134;   z. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 135;   aa. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 136;   bb. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 137;   cc. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 138;   dd. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 139;   ee. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 140;   ff. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 141;   gg. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 142;   hh. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 143;   ii. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 144;   jj. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 145;   kk. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 146;   ll. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 147;   mm. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 148;   nn. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 149;   oo. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 150;   pp. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 221;   qq. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 222;   rr. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 223;   ss. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 224;   tt. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 225;   uu. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 226;   vv. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 227;   ww. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of 228;   xx. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 229;   yy. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 230;   zz. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 231;   aaa. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 244;   bbb. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO SEQ ID NO 245;   ccc. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 246;   ddd. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 247;   eee. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 248; and   fff. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 249.       

     In a further embodiment, the invention relates to an animal feed additive or animal feed premix comprising one or more polypeptides having superoxide dismutase (SOD), wherein the feed additive or premix further comprises
         a. one or more polypeptides having catalase activity and/or   b. one or more vitamins, wherein the one or more vitamins is preferably a fat-soluble vitamin, for example vitamin E.       

     In a preferred embodiment, a catalase is further added to the animal feed additive or animal feed or animal feed premix comprising the fungal SOD. A catalase may be classified as an EC 1.11.1.6 catalase or as an EP 1.11.1.21 catalase peroxidase. A preferred example of the catalase according to the invention is a polypeptide having at least 80% sequence identity to SEQ ID NO:6 and SEQ ID NO:7. 
     A preferred animal feed premix, animal feed additive, or animal feed comprises one or more polypeptides having superoxide dismutase (SOD), vitamin E and optionally selenium and is used as antioxidant, preferably in feed and feed premixes or as a replacement or partial replacement of antibiotics in animal feed. 
     Examples of commercial vitamin E and selenium are Rovimix®E50 and SePlex (DSM Nutritional Products). 
     In a further embodiment, the animal feed or animal feed additive further comprises one or more components selected from the list consisting of:
         i. one or more carriers;   ii. one or more microbes;   iii. one or more vitamins;   iv. one or more minerals;   v. one or more amino acids;   vi. one of more organic acids;   vii. and one or more other feed ingredients.       

     The animal feed or animal feed additive may furthermore comprise additional enzymes but enzymes other than fungal superoxide dismutase and optionally a catalase, are not essential for the beneficial effects of the invention. The feed additive typically comprises one or more fungal superoxide dismutases, one or more polypeptides having catalase activity and/or further comprising one or more vitamins. 
     In one aspect, the invention relates to an animal feed comprising an animal feed additive, one or more protein sources and one or more energy sources characterised in the animal feed further comprises one or more polypeptides having SOD activity, wherein the animal feed
         a. reduces FCR by between 1 to 10%; or   b. increases average daily WG by between 1 to 10%; or   c. increases average daily feed intake by between 1 to 10%; or   d. any combinations of a.-c.;   when feed to the animal as compared to animals fed a feed composition without the polypeptides.       

     In a further aspect, the invention relates to an animal feed comprising an animal feed additive, one or more protein sources and one or more energy sources characterised in the animal feed further comprises one or more polypeptides having SOD activity, wherein the animal feed
         a. improves or enhances immune response; or   b. reduces inflammation;   when feed to the animal as compared to animals fed a feed composition without the polypeptides.       

     A further aspect of the invention is directed to the prophylactic care or management, reduction or prevention of oxidative stress in a monogastric animal comprising administrating to said animal superoxide dismutase and optionally catalase. Oxidative stress is a disturbance between antioxidant/oxidant status in favor of excessive generation, or slower removal of free radicals, such as reactive oxygen species (ROS). Excessive ROS content leads to damage of proteins, lipids and nucleic acids, with consequent loss of their biological functions and subsequent tissue injury. Oxidative stress has been linked to initiation and progression of several infectious diseases. Accordingly, a further aspect of the invention is the prophylactic care or management of infectious diseases in monogastric animal comprising administrating to said animal superoxide dismutase and optionally catalase. The administration is typically by means of feeding said animal a feed additive comprising an enzyme component, wherein the enzyme component comprises all of the enzymes of the additive and consists of a superoxide dismutase and optionally of a catalase. 
     In respect to the improvement of one or more performance parameters, the inventions is particularly characterized in that the EPEF and/or FCR and/or GR and/or WG is improved by at least 1% and that the MR is reduced by at least 1%. 
     The animal is a mono-gastric animal, e.g. pigs or swine (including, but not limited to, piglets, growing pigs, and sows); poultry (including but not limited to poultry, turkey, duck, quail, guinea fowl, goose, pigeon, squab, chicken, broiler, layer, pullet and chick); pets (including but not limited to cats and dogs); fish (including but not limited to amberjack, arapaima, barb, bass, bluefish, bocachico, bream, bullhead, cachama, carp, catfish, catla, chanos, char, cichlid, cobia, cod, crappie, dorada, drum, eel, goby, goldfish, gourami, grouper, guapote, halibut, java, labeo, lai, loach, mackerel, milkfish, mojarra, mudfish, mullet, paco, pearlspot, pejerrey, perch, pike, pompano, roach, salmon, sampa, sauger, sea bass, seabream, shiner, sleeper, snakehead, snapper, snook, sole, spinefoot, sturgeon, sunfish, sweetfish, tench, terror, tilapia, trout, tuna, turbot, vendace, walleye and whitefish); and crustaceans (including but not limited to shrimps and prawns). In a more preferred embodiment, the animal is selected from the group consisting of swine, poultry, crustaceans and fish. In an even more preferred embodiment, the animal is selected from the group consisting of swine, piglet, growing pig, sow, chicken, broiler, layer, pullet and chick, typically wherein the animal has experienced heat stress, cold stress, nutritional stress and/or oxidative stress. 
     The polypeptide having catalase activity is preferably dosed at a level of 100 to 1000 U enzyme protein per kg animal feed, such as 200 to 900 U, 300 to 800, 400 to 700, 500 to 600 enzyme protein per kg animal feed, or any combination of these intervals. 
     The polypeptide having superoxide dismutase activity is preferably dosed at a level of 100 to 5000 U enzyme protein per kg animal feed, such as 200 to 3000 U, 500 to 2500 U, 500 to 2000 U, 500 to 1500 U enzyme protein per kg animal feed, or any combination of these intervals. 
     Examples of dosing include SEQ ID No. 1 at 1250 or 2500 U/kg, SEQ ID NO 7 and SEQ ID NO 250 at 100 U/kg) and combinations (SEQ ID No. 1: 500 U/kg+SEQ ID NO 7: 100 U/kg; and SEQ ID No. 1: 500 U/kg+SEQ ID NO 250: 100 U/kg. 
     The protein source of the animal feed is selected from the group consisting of soybean, wild soybean, beans, lupin, tepary bean, scarlet runner bean, slimjim bean, lima bean, French bean, Broad bean (fava bean), chickpea, lentil, peanut, Spanish peanut, canola, sunflower seed, cotton seed, rapeseed (oilseed rape) or pea or in a processed form such as soybean meal, full fat soy bean meal, soy protein concentrate (SPC), fermented soybean meal (FSBM), sunflower meal, cotton seed meal, rapeseed meal, fish meal, bone meal, feather meal, whey or any combination thereof. 
     The energy source of the animal feed is selected from the group consisting of maize, corn, sorghum, barley, wheat, oats, rice, triticale, rye, beet, sugar beet, spinach, potato, cassava, quinoa, cabbage, switchgrass, millet, pearl millet, foxtail millet or in a processed form such as milled corn, milled maize, potato starch, cassava starch, milled sorghum, milled switchgrass, milled millet, milled foxtail millet, milled pearl millet, or any combination thereof. 
     In a preferred example, the animal feed further comprises one or more components selected from the list consisting of one or more additional enzymes; one or more microbes; one or more vitamins; one or more minerals; one or more amino acids; and one or more other feed ingredients, as described herein. 
     Methods of the Invention 
     In a further aspect, the invention relates to a method of improving one or more performance parameters in an animal comprising administering to the animal an animal feed or animal feed additive comprising one or more polypeptides having superoxide dismutase (SOD) activity of fungal origin, wherein the one or more performance parameters is selected from the group consisting of the European Production Efficiency Factor (EPEF), Feed Conversion Ratio (FCR), Growth Rate (GR), Body Weight Gain (WG), Mortality Rate (MR) and Flock Uniformity (FU). 
     In a further aspect, the invention relates to a method of improving or enhancing immune response and/or reducing inflammation and/or for the modulation of the gut flora in an animal comprising administering to the animal an animal feed or animal feed additive comprising one or more polypeptides having superoxide dismutase activity. A related aspect of the invention is directed to the prophylactic care or management, reduction or prevention of inflammation in the intestinal tract of a monogastric animal. 
     In a further aspect, the invention relates to a method of reducing or eliminating the use of antibiotics administered to animal feed, comprising administering to the animal an animal feed or animal feed additive comprising of one or more polypeptides having superoxide dismutase activity. 
     In a further aspect, the invention relates to a method of reducing cellular markers of reactive oxygen species or free radicals in animal body comprising administering to the animal an animal feed or animal feed additive comprising one or more polypeptides having superoxide dismutase (SOD) activity. 
     A further aspect of the invention is directed to the prophylactic care or management, reduction or prevention of oxidative stress in a monogastric animal comprising administrating to said animal superoxide dismutase and optionally catalase. Oxidative stress is a disturbance between antioxidant/oxidant status in favor of excessive generation, or slower removal of free radicals, such as reactive oxygen species (ROS). Excessive ROS content leads to damage of proteins, lipids and nucleic acids, with consequent loss of their biological functions and subsequent tissue injury. Oxidative stress has been linked to initiation and progression of several infectious diseases. Accordingly, a further aspect of the invention is the prophylactic care or management of infectious diseases in monogastric animal comprising administrating to said animal superoxide dismutase and optionally catalase. The administration is typically by means of feeding said animal a feed additive comprising an enzyme component, wherein the enzyme component comprises all of the enzymes of the additive and consists of a superoxide dismutase and optionally of a catalase. 
     In respect to the improvement of one or more performance parameters, the inventions is particularly characterized in that the EPEF and/or FCR and/or GR and/or WG is improved by at least 1% and that the MR is reduced by at least 1%. 
     The animal is a mono-gastric animal, e.g. pigs or swine (including, but not limited to, piglets, growing pigs, and sows); poultry (including but not limited to poultry, turkey, duck, quail, guinea fowl, goose, pigeon, squab, chicken, broiler, layer, pullet and chick); pets (including but not limited to cats and dogs); fish (including but not limited to amberjack, arapaima, barb, bass, bluefish, bocachico, bream, bullhead, cachama, carp, catfish, catla, chanos, char, cichlid, cobia, cod, crappie, dorada, drum, eel, goby, goldfish, gourami, grouper, guapote, halibut, java, labeo, lai, loach, mackerel, milkfish, mojarra, mudfish, mullet, paco, pearlspot, pejerrey, perch, pike, pompano, roach, salmon, sampa, sauger, sea bass, seabream, shiner, sleeper, snakehead, snapper, snook, sole, spinefoot, sturgeon, sunfish, sweetfish, tench, terror, tilapia, trout, tuna, turbot, vendace, walleye and whitefish); and crustaceans (including but not limited to shrimps and prawns). In a more preferred embodiment, the animal is selected from the group consisting of swine, poultry, crustaceans and fish. In an even more preferred embodiment, the animal is selected from the group consisting of swine, piglet, growing pig, sow, chicken, broiler, layer, pullet and chick, typically wherein the animal has experienced heat stress, cold stress, nutritional stress and/or oxidative stress. 
     A further aspect of the invention is directed to a method of feeding poultry or pigs comprising adding the animal feed additive of the invention to a raw feed material. 
     A further aspect of the invention is directed to a method of feeding an animal, wherein the animal feed or animal feed additive further comprises one or more components selected from the list consisting of: 
     viii. one or more carriers; 
     ix. one or more microbes; 
     x. one or more vitamins; 
     xi. one or more minerals; 
     xii. one or more amino acids; 
     xiii. one of more organic acids; 
     xiv. and one or more other feed ingredients. 
     One may furthermore administer additional enzymes but enzymes other than fungal superoxide dismutase and optionally a catalase, are not essential for the beneficial effects of the invention. 
     Enzyme Compositions and Formulations 
     The polypeptide having SOD activity of the invention may be formulated as a liquid or a solid. For a liquid formulation, the formulating agent may comprise a polyol (such as e.g. glycerol, ethylene glycol or propylene glycol), a salt (such as e.g. sodium chloride, sodium benzoate, potassium sorbate) or a sugar or sugar derivative (such as e.g. dextrin, glucose, sucrose, and sorbitol). Thus, in one embodiment, the composition is a liquid composition comprising the polypeptide of the invention and one or more formulating agents selected from the list consisting of glycerol, ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, sodium chloride, sodium benzoate, potassium sorbate, dextrin, glucose, sucrose, and sorbitol. The liquid formulation may be sprayed onto the feed after it has been pelleted or may be added to drinking water given to the animals. 
     In one embodiment, the liquid formulation further comprises 20%-80% polyol (i.e. total amount of polyol), preferably 25%-75% polyol, more preferably 30%-70% polyol, more preferably 35%-65% polyol or most preferably 40%-60% polyol. In one embodiment, the liquid formulation comprises 20%-80% polyol, preferably 25%-75% polyol, more preferably 30%-70% polyol, more preferably 35%-65% polyol or most preferably 40%-60% polyol wherein the polyol is selected from the group consisting of glycerol, sorbitol, propylene glycol (MPG), ethylene glycol, diethylene glycol, triethylene glycol, 1, 2-propylene glycol or 1, 3-propylene glycol, dipropylene glycol, polyethylene glycol (PEG) having an average molecular weight below about 600 and polypropylene glycol (PPG) having an average molecular weight below about 600. In one embodiment, the liquid formulation comprises 20%-80% polyol (i.e. total amount of polyol), preferably 25%-75% polyol, more preferably 30%-70% polyol, more preferably 35%-65% polyol or most preferably 40%-60% polyol wherein the polyol is selected from the group consisting of glycerol, sorbitol and propylene glycol (MPG). 
     In one embodiment, the liquid formulation further comprises preservative, preferably selected from the group consisting of sodium sorbate, potassium sorbate, sodium benzoate and potassium benzoate or any combination thereof. In one embodiment, the liquid formulation comprises 0.02% to 1.5% w/w preservative, more preferably 0.05% to 1.0% w/w preservative or most preferably 0.1% to 0.5% w/w preservative. In one embodiment, the liquid formulation comprises 0.001% to 2.0% w/w preservative (i.e. total amount of preservative), preferably 0.02% to 1.5% w/w preservative, more preferably 0.05% to 1.0% w/w preservative or most preferably 0.1% to 0.5% w/w preservative wherein the preservative is selected from the group consisting of sodium sorbate, potassium sorbate, sodium benzoate and potassium benzoate or any combination thereof. 
     For a solid formulation, the formulation may be for example as a granule, spray dried powder or agglomerate (e.g. as disclosed in WO2000/70034). The formulating agent may comprise a salt (organic or inorganic zinc, sodium, potassium or calcium salts such as e.g. such as calcium acetate, calcium benzoate, calcium carbonate, calcium chloride, calcium citrate, calcium sorbate, calcium sulfate, potassium acetate, potassium benzoate, potassium carbonate, potassium chloride, potassium citrate, potassium sorbate, potassium sulfate, sodium acetate, sodium benzoate, sodium carbonate, sodium chloride, sodium citrate, sodium sulfate, zinc acetate, zinc benzoate, zinc carbonate, zinc chloride, zinc citrate, zinc sorbate, zinc sulfate), starch or a sugar or sugar derivative (such as e.g. sucrose, dextrin, glucose, lactose, sorbitol). 
     In one embodiment, the composition is a solid composition, such as a spray dried composition, comprising the polypeptide having SOD activity of the invention and one or more formulating agents selected from the list consisting of sodium chloride, sodium benzoate, potassium sorbate, sodium sulfate, potassium sulfate, magnesium sulfate, sodium thiosulfate, calcium carbonate, sodium citrate, dextrin, glucose, sucrose, sorbitol, lactose, starch and cellulose. In a preferred embodiment, the formulating agent is selected from one or more of the following compounds: sodium sulfate, dextrin, cellulose, sodium thiosulfate, magnesium sulfate and calcium carbonate. 
     The present invention also relates to enzyme granules/particles comprising the polypeptide having SOD activity of the invention optionally combined with one or more additional enzymes. The granule is composed of a core, and optionally one or more coatings (outer layers) surrounding the core. 
     Typically, the granule/particle size, measured as equivalent spherical diameter (volume based average particle size), of the granule is 20-2000 μm, particularly 50-1500 μm, 100-1500 μm or 250-1200 μm. 
     The core can be prepared by granulating a blend of the ingredients, e.g., by a method comprising granulation techniques such as crystallization, precipitation, pan-coating, fluid bed coating, fluid bed agglomeration, rotary atomization, extrusion, prilling, spheronization, size reduction methods, drum granulation, and/or high shear granulation. 
     Methods for preparing the core can be found in Handbook of Powder Technology; Particle size enlargement by C. E. Capes; Volume 1; 1980; Elsevier. Preparation methods include known feed and granule formulation technologies, e.g.: 
     a) spray dried products, wherein a liquid enzyme-containing solution is atomized in a spray drying tower to form small droplets which during their way down the drying tower dry to form an enzyme-containing particulate material; 
     b) layered products, wherein the enzyme is coated as a layer around a pre-formed inert core particle, wherein an enzyme-containing solution is atomized, typically in a fluid bed apparatus wherein the pre-formed core particles are fluidized, and the enzyme-containing solution adheres to the core particles and dries up to leave a layer of dry enzyme on the surface of the core particle. Particles of a desired size can be obtained this way if a useful core particle of the desired size can be found. This type of product is described in, e.g., WO 97/23606; 
     c) absorbed core particles, wherein rather than coating the enzyme as a layer around the core, the enzyme is absorbed onto and/or into the surface of the core. Such a process is described in WO 97/39116. 
     d) extrusion or pelletized products, wherein an enzyme-containing paste is pressed to pellets or under pressure is extruded through a small opening and cut into particles which are subsequently dried. Such particles usually have a considerable size because of the material in which the extrusion opening is made (usually a plate with bore holes) sets a limit on the allowable pressure drop over the extrusion opening. Also, very high extrusion pressures when using a small opening increase heat generation in the enzyme paste, which is harmful to the enzyme; 
     e) prilled products, wherein an enzyme-containing powder is suspended in molten wax and the suspension is sprayed, e.g., through a rotating disk atomiser, into a cooling chamber where the droplets quickly solidify (Michael S. Showell (editor); Powdered detergents; Surfactant Science Series; 1998; vol. 71; page 140-142; Marcel Dekker). The product obtained is one wherein the enzyme is uniformly distributed throughout an inert material instead of being concentrated on its surface. Also U.S. Pat. Nos. 4,016,040 and 4,713,245 are documents relating to this technique; 
     f) mixer granulation products, wherein a liquid is added to a dry powder composition of, e.g., conventional granulating components, the enzyme being introduced either via the liquid or the powder or both. The liquid and the powder are mixed and as the moisture of the liquid is absorbed in the dry powder, the components of the dry powder will start to adhere and agglomerate and particles will build up, forming granulates comprising the enzyme. Such a process is described in U.S. Pat. No. 4,106,991 and related documents EP 170360, EP 304332, EP 304331, WO 90/09440 and WO 90/09428. In a particular product of this process wherein various high-shear mixers can be used as granulators, granulates consisting of enzyme as enzyme, fillers and binders etc. are mixed with cellulose fibres to reinforce the particles to give the so-called T-granulate. Reinforced particles, being more robust, release less enzymatic dust. 
     g) size reduction, wherein the cores are produced by milling or crushing of larger particles, pellets, tablets, briquettes etc. containing the enzyme. The wanted core particle fraction is obtained by sieving the milled or crushed product. Over and undersized particles can be recycled. Size reduction is described in (Martin Rhodes (editor); Principles of Powder Technology; 1990; Chapter 10; John Wiley &amp; Sons); 
     h) fluid bed granulation, which involves suspending particulates in an air stream and spraying a liquid onto the fluidized particles via nozzles. Particles hit by spray droplets get wetted and become tacky. The tacky particles collide with other particles and adhere to them and form a granule; 
     i) the cores may be subjected to drying, such as in a fluid bed drier. Other known methods for drying granules in the feed or detergent industry can be used by the skilled person. The drying preferably takes place at a product temperature of from 25 to 90° C. For some enzymes it is important the cores comprising the enzyme contain a low amount of water before coating. If water sensitive enzymes are coated before excessive water is removed, it will be trapped within the core and it may affect the activity of the enzyme negatively. After drying, the cores preferably contain 0.1-10% w/w water. 
     The core may include additional materials such as fillers, fibre materials (cellulose or synthetic fibres), stabilizing agents, solubilizing agents, suspension agents, viscosity regulating agents, light spheres, plasticizers, salts, lubricants and fragrances. 
     The core may include a binder, such as synthetic polymer, wax, fat, or carbohydrate. 
     The core may include a salt of a multivalent cation, a reducing agent, an antioxidant, a peroxide decomposing catalyst and/or an acidic buffer component, typically as a homogenous blend. 
     In one embodiment, the core comprises a material selected from the group consisting of salts (such as calcium acetate, calcium benzoate, calcium carbonate, calcium chloride, calcium citrate, calcium sorbate, calcium sulfate, potassium acetate, potassium benzoate, potassium carbonate, potassium chloride, potassium citrate, potassium sorbate, potassium sulfate, sodium acetate, sodium benzoate, sodium carbonate, sodium chloride, sodium citrate, sodium sulfate, zinc acetate, zinc benzoate, zinc carbonate, zinc chloride, zinc citrate, zinc sorbate, zinc sulfate), starch or a sugar or sugar derivative (such as e.g. sucrose, dextrin, glucose, lactose, sorbitol), sugar or sugar derivative (such as e.g. sucrose, dextrin, glucose, lactose, sorbitol), small organic molecules, starch, flour, cellulose and minerals and clay minerals (also known as hydrous aluminium phyllosilicates). In one embodiment, the core comprises a clay mineral such as kaolinite or kaolin. 
     The core may include an inert particle with the enzyme absorbed into it, or applied onto the surface, e.g., by fluid bed coating. 
     The core may have a diameter of 20-2000 μm, particularly 50-1500 μm, 100-1500 μm or 250-1200 μm. 
     The core may be surrounded by at least one coating, e.g., to improve the storage stability, to reduce dust formation during handling, or for coloring the granule. The optional coating(s) may include a salt and/or wax and/or flour coating, or other suitable coating materials. 
     The coating may be applied in an amount of at least 0.1% by weight of the core, e.g., at least 0.5%, 1% or 5%. The amount may be at most 100%, 70%, 50%, 40% or 30%. 
     The coating is preferably at least 0.1 μm thick, particularly at least 0.5 μm, at least 1 μm or at least 5 μm. In some embodiments the thickness of the coating is below 100 μm, such as below 60 μm, or below 40 μm. 
     The coating should encapsulate the core unit by forming a substantially continuous layer. A substantially continuous layer is to be understood as a coating having few or no holes, so that the core unit is encapsulated or enclosed with few or no uncoated areas. The layer or coating should in particular be homogeneous in thickness. 
     The coating can further contain other materials as known in the art, e.g., fillers, antisticking agents, pigments, dyes, plasticizers and/or binders, such as titanium dioxide, kaolin, calcium carbonate or talc. 
     The granule may comprise a core comprising the polypeptide having SOD activity of the invention, one or more salt coatings and one or more wax coatings. Examples of enzyme granules with multiple coatings are shown in WO1993/07263, WO1997/23606 and WO2016/149636. 
     A salt coating may comprise at least 60% by weight of a salt, e.g., at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95% or at least 99% by weight. 
     The salt may be added from a salt solution where the salt is completely dissolved or from a salt suspension wherein the fine particles are less than 50 μm, such as less than 10 μm or less than 5 μm. 
     The salt coating may comprise a single salt or a mixture of two or more salts. The salt may be water soluble, in particular having a solubility at least 0.1 g in 100 g of water at 20° C., preferably at least 0.5 g per 100 g water, e.g., at least 1 g per 100 g water, e.g., at least 5 g per 100 g water. 
     The salt may be an inorganic salt, e.g., salts of sulfate, sulfite, phosphate, phosphonate, nitrate, chloride or carbonate or salts of simple organic acids (less than 10 carbon atoms, e.g., 6 or less carbon atoms) such as citrate, malonate or acetate. Examples of cations in these salts are alkali or earth alkali metal ions, the ammonium ion or metal ions of the first transition series, such as sodium, potassium, magnesium, calcium, zinc or aluminium. Examples of anions include chloride, bromide, iodide, sulfate, sulfite, bisulfite, thiosulfate, phosphate, monobasic phosphate, dibasic phosphate, hypophosphite, dihydrogen pyrophosphate, tetraborate, borate, carbonate, bicarbonate, metasilicate, citrate, malate, maleate, malonate, succinate, sorbate, lactate, formate, acetate, butyrate, propionate, benzoate, tartrate, ascorbate or gluconate. In particular alkali- or earth alkali metal salts of sulfate, sulfite, phosphate, phosphonate, nitrate, chloride or carbonate or salts of simple organic acids such as citrate, malonate or acetate may be used. 
     The salt in the coating may have a constant humidity at 20° C. above 60%, particularly above 70%, above 80% or above 85%, or it may be another hydrate form of such a salt (e.g., anhydrate). The salt coating may be as described in WO1997/05245, WO1998/54980, WO1998/55599, WO2000/70034, WO2006/034710, WO2008/017661, WO2008/017659, WO2000/020569, WO2001/004279, WO1997/05245, WO2000/01793, WO2003/059086, WO2003/059087, WO2007/031483, WO2007/031485, WO2007/044968, WO2013/192043, WO2014/014647 and WO2015/197719 or polymer coating such as described in WO 2001/00042. 
     Specific examples of suitable salts are NaCl (CH20° C.=76%), Na2CO3 (CH20° C.=92%), NaNO3 (CH20° C.=73%), Na2HPO4 (CH20° C.=95%), Na3PO4 (CH25° C.=92%), NH4Cl (CH20° C.=79.5%), (NH4)2HPO4 (CH20° C.=93%), NH4H2PO4 (CH20° C.=93.1%), (NH4)2SO4 (CH20° C.=81.1%), KCl (CH20° C.=85%), K2HPO4 (CH20° C.=92%), KH2PO4 (CH20° C.=96.5%), KNO3 (CH20° C.=93.5%), Na2SO4 (CH20° C.=93%), K2SO4 (CH20° C.=98%), KHSO4 (CH20° C.=86%), MgSO4 (CH20° C.=90%), ZnSO4 (CH20° C.=90%) and sodium citrate (CH25° C.=86%). Other examples include NaH2PO4, (NH4)H2PO4, CuSO4, Mg(NO3)2, magnesium acetate, calcium acetate, calcium benzoate, calcium carbonate, calcium chloride, calcium citrate, calcium sorbate, calcium sulfate, potassium acetate, potassium benzoate, potassium carbonate, potassium chloride, potassium citrate, potassium sorbate, sodium acetate, sodium benzoate, sodium citrate, sodium sulfate, zinc acetate, zinc benzoate, zinc carbonate, zinc chloride, zinc citrate and zinc sorbate. 
     The salt may be in anhydrous form, or it may be a hydrated salt, i.e. a crystalline salt hydrate with bound water(s) of crystallization, such as described in WO 99/32595. Specific examples include anhydrous sodium sulfate (Na2SO4), anhydrous magnesium sulfate (MgSO4), magnesium sulfate heptahydrate (MgSO4.7H2O), zinc sulfate heptahydrate (ZnSO4.7H2O), sodium phosphate dibasic heptahydrate (Na2HPO4.7H2O), magnesium nitrate hexahydrate (Mg(NO3)2(6H2O)), sodium citrate dihydrate and magnesium acetate tetrahydrate. 
     Preferably the salt is applied as a solution of the salt, e.g., using a fluid bed. 
     A wax coating may comprise at least 60% by weight of a wax, e.g., at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95% or at least 99% by weight. 
     Specific examples of waxes are polyethylene glycols; polypropylenes; Carnauba wax; Candelilla wax; bees wax; hydrogenated plant oil or animal tallow such as polyethylene glycol (PEG), methyl hydroxy-propyl cellulose (MHPC), polyvinyl alcohol (PVA), hydrogenated ox tallow, hydrogenated palm oil, hydrogenated cotton seeds and/or hydrogenated soy bean oil; fatty acid alcohols; mono-glycerides and/or di-glycerides, such as glyceryl stearate, wherein stearate is a mixture of stearic and palmitic acid; micro-crystalline wax; paraffin&#39;s; and fatty acids, such as hydrogenated linear long chained fatty acids and derivatives thereof. A preferred wax is palm oil or hydrogenated palm oil. 
     Non-dusting granulates may be produced, e.g., as disclosed in U.S. Pat. Nos. 4,106,991 and 4,661,452 and may optionally be coated by methods known in the art. The coating materials can be waxy coating materials and film-forming coating materials. Examples of waxy coating materials are poly(ethylene oxide) products (polyethyleneglycol, PEG) with mean molar weights of 1000 to 20000; ethoxylated nonylphenols having from 16 to 50 ethylene oxide units; ethoxylated fatty alcohols in which the alcohol contains from 12 to 20 carbon atoms and in which there are 15 to 80 ethylene oxide units; fatty alcohols; fatty acids; and mono- and di- and triglycerides of fatty acids. Examples of film-forming coating materials suitable for application by fluid bed techniques are given in GB 1483591. 
     The granulate may further comprise one or more additional enzymes. Each enzyme will then be present in more granules securing a more uniform distribution of the enzymes, and also reduces the physical segregation of different enzymes due to different particle sizes. Methods for producing multi-enzyme co-granulates is disclosed in the ip.com disclosure IPCOM000200739D. 
     Animal Feed 
     Animal feed compositions or diets have a relatively high content of protein. Poultry and pig diets can be characterised as indicated in Table B of WO 01/58275, columns 2-3. Fish diets can be characterised as indicated in column 4 of this Table B. Furthermore, such fish diets usually have a crude fat content of 200-310 g/kg. 
     An animal feed composition according to the invention has a crude protein content of 50-800 g/kg, and furthermore comprises one or more polypeptides having SOD activity as described herein. 
     Furthermore, or in the alternative (to the crude protein content indicated above), the animal feed composition of the invention has a content of metabolisable energy of 10-30 MJ/kg; and/or a content of calcium of 0.1-200 g/kg; and/or a content of available phosphorus of 0.1-200 g/kg; and/or a content of methionine of 0.1-100 g/kg; and/or a content of methionine plus cysteine of 0.1-150 g/kg; and/or a content of lysine of 0.5-50 g/kg. 
     In particular embodiments, the content of metabolisable energy, crude protein, calcium, phosphorus, methionine, methionine plus cysteine, and/or lysine is within any one of ranges 2, 3, 4 or 5 in Table B of WO 01/58275 (R. 2-5). 
     Crude protein is calculated as nitrogen (N) multiplied by a factor 6.25, i.e. Crude protein (g/kg)=N (g/kg)×6.25. The nitrogen content is determined by the Kjeldahl method (A.O.A.C., 1984, Official Methods of Analysis 14th ed., Association of Official Analytical Chemists, Washington D.C.). 
     Metabolisable energy can be calculated on the basis of the NRC publication Nutrient requirements in swine, ninth revised edition 1988, subcommittee on swine nutrition, committee on animal nutrition, board of agriculture, national research council. National Academy Press, Washington, D.C., pp. 2-6, and the European Table of Energy Values for Poultry Feed-stuffs, Spelderholt centre for poultry research and extension, 7361 DA Beekbergen, The Netherlands. Grafisch bedrijf Ponsen &amp; looijen by, Wageningen. ISBN 90-71463-12-5. 
     The dietary content of calcium, available phosphorus and amino acids in complete animal diets is calculated on the basis of feed tables such as Veevoedertabel 1997, gegevens over chemische samenstelling, verteerbaarheid en voederwaarde van voedermiddelen, Central Veevoederbureau, Runderweg 6, 8219 pk Lelystad. ISBN 90-72839-13-7. 
     In a particular embodiment, the animal feed composition of the invention contains at least one vegetable protein as defined above. 
     The animal feed composition of the invention may also contain animal protein, such as Meat and Bone Meal, Feather meal, and/or Fish Meal, typically in an amount of 0-25%. The animal feed composition of the invention may also comprise Dried Distillers Grains with Solubles (DDGS), typically in amounts of 0-30%. 
     In still further particular embodiments, the animal feed composition of the invention contains 0-80% maize; and/or 0-80% sorghum; and/or 0-70% wheat; and/or 0-70% Barley; and/or 0-30% oats; and/or 0-40% soybean meal; and/or 0-25% fish meal; and/or 0-25% meat and bone meal; and/or 0-20% whey. 
     The animal feed may comprise vegetable proteins. In particular embodiments, the protein content of the vegetable proteins is at least 10, 20, 30, 40, 50, 60, 70, 80, or 90% (w/w). Vegetable proteins may be derived from vegetable protein sources, such as legumes and cereals, for example, materials from plants of the families Fabaceae (Leguminosae), Cruciferaceae, Chenopodiaceae, and Poaceae, such as soy bean meal, lupin meal, rapeseed meal, and combinations thereof. 
     In a particular embodiment, the vegetable protein source is material from one or more plants of the family Fabaceae, e.g., soybean, lupine, pea, or bean. In another particular embodiment, the vegetable protein source is material from one or more plants of the family Chenopodiaceae, e.g. beet, sugar beet, spinach or quinoa. Other examples of vegetable protein sources are rapeseed, and cabbage. In another particular embodiment, soybean is a preferred vegetable protein source. Other examples of vegetable protein sources are cereals such as barley, wheat, rye, oat, maize (corn), rice, and sorghum. 
     Animal diets can e.g. be manufactured as mash feed (non-pelleted) or pelleted feed. Typically, the milled feed-stuffs are mixed and sufficient amounts of essential vitamins and minerals are added according to the specifications for the species in question. Enzymes can be added as solid or liquid enzyme formulations. For example, for mash feed a solid or liquid enzyme formulation may be added before or during the ingredient mixing step. For pelleted feed the (liquid or solid) SOD/enzyme preparation may also be added before or during the feed ingredient step. Typically a liquid enzyme preparation comprises the SOD of the invention optionally with a polyol, such as glycerol, ethylene glycol or propylene glycol, and is added after the pelleting step, such as by spraying the liquid formulation onto the pellets. The SOD may also be incorporated in a feed additive or premix. 
     In an embodiment, the composition comprises one or more additional enzymes. In an embodiment, the composition comprises one or more microbes. In an embodiment, the composition comprises one or more vitamins. In an embodiment, the composition comprises one or more minerals. In an embodiment, the composition comprises one or more amino acids. In an embodiment, the composition comprises one or more other feed ingredients. 
     In another embodiment, the composition comprises one or more of the polypeptides of the invention, one or more formulating agents and one or more additional enzymes. In an embodiment, the composition comprises one or more of the polypeptides of the invention, one or more formulating agents and one or more microbes. In an embodiment, the composition comprises one or more of the polypeptides of the invention, one or more formulating agents and one or more vitamins. In an embodiment, the composition comprises one or more of the polypeptides of the invention and one or more minerals. In an embodiment, the composition comprises the polypeptide of the invention, one or more formulating agents and one or more amino acids. In an embodiment, the composition comprises one or more of the polypeptides of the invention, one or more formulating agents and one or more other feed ingredients. 
     In a further embodiment, the composition comprises one or more of the polypeptides of the invention, one or more formulating agents and one or more components selected from the list consisting of: one or more additional enzymes; one or more microbes; one or more vitamins; one or more minerals; one or more amino acids; and one or more other feed ingredients. 
     The final SOD concentration in the diet is within the range of 100 to 1000 mg enzyme protein per kg animal feed, such as 200 to 900 mg, 300 to 800 mg, 400 to 700 mg, 500 to 600 mg enzyme protein per kg animal feed, or any combination of these intervals. 
     The final SOD concentration in the diet can also be determined in Units/kg feed, which is within the range of 100 to 3000 Units per kg animal feed, such as 200 to 3000 U/kg, 300 to 2000 U/kg, 100 to 800 U/kg, 100 to 400 U/kg, or any combination of these intervals. 
     In another embodiment, the compositions described herein optionally include one or more enzymes for improving feed digestibility. Enzymes can be classified on the basis of the handbook Enzyme Nomenclature from NC-IUBMB, 1992), see also the ENZYME site at the internet: http://www.expasy.ch/enzyme/. ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUB-MB), Academic Press, Inc., 1992, and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided (Bairoch A. The ENZYME database, 2000, Nucleic Acids Res 28:304-305). This IUB-MB Enzyme nomenclature is based on their substrate specificity and occasionally on their molecular mechanism; such a classification does not reflect the structural features of these enzymes. 
     Thus the composition of the invention may also comprise at least one other enzyme selected from the group comprising of acetylxylan esterase (EC 3.1.1.23), acylglycerol lipase (EC 3.1.1.72), alpha-amylase (EC 3.2.1.1), beta-amylase (EC 3.2.1.2), arabinofuranosidase (EC 3.2.1.55), cellobiohydrolases (EC 3.2.1.91), cellulase (EC 3.2.1.4), feruloyl esterase (EC 3.1.1.73), galactanase (EC 3.2.1.89), alpha-galactosidase (EC 3.2.1.22), beta-galactosidase (EC 3.2.1.23), beta-glucanase (EC 3.2.1.6), beta-glucosidase (EC 3.2.1.21), triacylglycerol lipase (EC 3.1.1.3), lysophospholipase (EC 3.1.1.5), alpha-mannosidase (EC 3.2.1.24), beta-mannosidase (mannanase) (EC 3.2.1.25), phytase (EC 3.1.3.8, EC 3.1.3.26, EC 3.1.3.72), phospholipase A1 (EC 3.1.1.32), phospholipase A2 (EC 3.1.1.4), phospholipase D (EC 3.1.4.4), pullulanase (EC 3.2.1.41), pectinesterase (EC 3.1.1.11), beta-xylosidase (EC 3.2.1.37), or any combination thereof. 
     In another embodiment, the animal feed may include one or more vitamins, such as one or more fat-soluble vitamins and/or one or more water-soluble vitamins. In another embodiment, the animal feed may optionally include one or more minerals, such as one or more trace minerals and/or one or more macro minerals. 
     Usually fat- and water-soluble vitamins, as well as trace minerals form part of a so-called premix intended for addition to the feed, whereas macro minerals are usually separately added to the feed. 
     Non-limiting examples of fat-soluble vitamins include vitamin A, vitamin D3, vitamin E, and vitamin K, e.g., vitamin K3. 
     Non-limiting examples of water-soluble vitamins include vitamin C, vitamin B12, biotin and choline, vitamin B1, vitamin B2, vitamin B6, niacin, folic acid and panthothenate, e.g., Ca-D-panthothenate. 
     Non-limiting examples of trace minerals include boron, cobalt, chloride, chromium, copper, fluoride, iodine, iron, manganese, molybdenum, iodine, selenium and zinc. 
     Non-limiting examples of macro minerals include calcium, magnesium, phosphorus, potassium and sodium. 
     In one embodiment, the amount of vitamins is 0.001% to 10% by weight of the composition. In one embodiment, the amount of minerals is 0.001% to 10% by weight of the composition. 
     The nutritional requirements of these components (exemplified with poultry and piglets/pigs) are listed in Table A of WO 01/58275. Nutritional requirement means that these components should be provided in the diet in the concentrations indicated. 
     In the alternative, the animal feed additive of the invention comprises at least one of the individual components specified in Table A of WO 01/58275. At least one means either of, one or more of, one, or two, or three, or four and so forth up to all thirteen, or up to all fifteen individual components. More specifically, this at least one individual component is included in the additive of the invention in such an amount as to provide an in-feed-concentration within the range indicated in column four, or column five, or column six of Table A. 
     In a still further embodiment, the animal feed additive of the invention comprises at least one of the below vitamins, preferably to provide an in-feed-concentration within the ranges specified in the below Table 1 (for piglet diets, and broiler diets, respectively). 
     In the suitable embodiments, the invention relates to an animal feed and a method of improving one or more performance parameters in an animal comprising administering to the animal an animal feed or animal feed additive comprising one or more polypeptides having superoxide dismutase (SOD) activity, wherein the one or more performance parameters is selected from the group consisting of the European Production Efficiency Factor (EPEF), Feed Conversion Ratio (FCR), Growth Rate (GR), Body Weight Gain (WG), Mortility Rate (MR) and Flock Uniformity (FU). 
     These features are supported by examples 1 and 2. As it is generally known, an improved FCR is lower than the control FCR. In particular embodiments, the FCR is improved (i.e., reduced) as compared to the control by at least 1.0%, preferably at least 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, or at least 2.5%. 
     The term “mortality” as used herein refers to the ratio of life animals at the end of the growth phase versus the number of animals originally included into the pond. It may be determined on the basis of a fish challenge trial comprising two groups of fish challenged by a particular fish pathogen with the aim to provoke a mortality of 40 to 80% of the animals in the untreated group. However, in the challenge group fed with a suitable concentration per Kg of feed of a mixture of at least two compounds according to the invention, the mortality is reduced compared to the untreated group by at least 5%, preferably at least, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, or at least 50%. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Typical vitamin recommendations 
               
            
           
           
               
               
               
            
               
                 Vitamin 
                 Piglet diet 
                 Broiler diet 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Vitamin A 
                 10,000-15,000 
                 IU/kg feed 
                 8-12,500 
                 IU/kg feed 
               
               
                 Vitamin D3 
                 1800-2000 
                 IU/kg feed 
                 3000-5000 
                 IU/kg feed 
               
               
                 Vitamin E 
                 60-100 
                 mg/kg feed 
                 150-240 
                 mg/kg feed 
               
               
                 Vitamin K3 
                 2-4 
                 mg/kg feed 
                 2-4 
                 mg/kg feed 
               
               
                 Vitamin B1 
                 2-4 
                 mg/kg feed 
                 2-3 
                 mg/kg feed 
               
               
                 Vitamin B2 
                 6-10 
                 mg/kg feed 
                 7-9 
                 mg/kg feed 
               
               
                 Vitamin B6 
                 4-8 
                 mg/kg feed 
                 3-6 
                 mg/kg feed 
               
               
                 Vitamin B12 
                 0.03-0.05 
                 mg/kg feed 
                 0.015-0.04 
                 mg/kg feed 
               
               
                 Niacin 
                 30-50 
                 mg/kg feed 
                 50-80 
                 mg/kg feed 
               
               
                 (Vitamin B3) 
               
               
                 Pantothenic 
                 20-40 
                 mg/kg feed 
                 10-18 
                 mg/kg feed 
               
               
                 acid 
               
               
                 Folic acid 
                 1-2 
                 mg/kg feed 
                 1-2 
                 mg/kg feed 
               
               
                 Biotin 
                 0.15-0.4 
                 mg/kg feed 
                 0.15-0.3 
                 mg/kg feed 
               
               
                 Choline 
                 200-400 
                 mg/kg feed 
                 300-600 
                 mg/kg feed 
               
               
                 chloride 
               
               
                   
               
            
           
         
       
     
     In some embodiments the invention relates to an animal feed and a method of improving or enhancing immune response and/or reducing inflammation and/or for the modulation of the gut flora in an animal comprising administering to the animal an animal feed or animal feed additive comprising one or more polypeptides having superoxide dismutase activity. 
     These features are supported by example 1 as the first two features are very much linked to oxidative stress. Different in-vitro models tested by the applicant also show that SODs optionally in combinations with a catalase are very effective to decrease oxidative stress/burst. 
     Dysregulating effects of heat stress and oxidative stress also help in maintaining gut integrity and function. Therefore, the invention also supports a positive modulation of the gut flora, in particular of the microbial gut flora. 
     The term “gut” as used herein designates the gastrointestinal or digestive tract (also referred to as the alimentary canal) and it refers to the system of organs within multi-cellular animals which takes in food, digests it to extract energy and nutrients, and expels the remaining waste. 
     The term gut “microflora” as used herein refers to the natural microbial cultures residing in the gut and maintaining health by aiding in proper digestion. 
     The term “modulate” as used herein in connection with the gut microflora generally means to change, manipulate, alter, or adjust the function or status thereof in a healthy and normally functioning animal, i.e. a non-therapeutic use. 
     The term “supporting immune system function” as used herein refers to the immune stimulation effect obtained by the compounds according to the invention. 
     In the fifth and sixth embodiment, the invention relates to a method of reducing or eliminating the use of antibiotics administered to animal feed or to a method of reducing cellular markers of reactive oxygen species or free radicals in animal body comprising administering to the animal an animal feed or animal feed additive comprising one or more polypeptides having superoxide dismutase (SOD) activity. These embodiments are supported by example 1. 
     In the seventh embodiment, the invention relates to an animal feed additive or animal feed premix comprising one or more polypeptides having superoxide dismutase (SOD), wherein the feed additive or premix further comprises
         one or more polypeptides having catalase activity and/or   one or more vitamins, wherein the one or more vitamins is preferably a fat-soluble vitamin, for example vitamin E.       

     If a catalase (CAT) is added to the final feed, the final CAT concentration in the diet is within the range of 100 to 1000 mg enzyme protein per kg animal feed, such as 200 to 900 mg, 300 to 800 mg, 400 to 700 mg, 500 to 600 mg enzyme protein per kg animal feed, or any combination of these intervals. 
     The final CAT concentration in the diet can also be determined in Units/kg feed, which is within the range of 50 to 1000 Units per kg animal feed, such as 50 to 800 U/kg, 100 to 800 U/kg, 100 to 500 U/kg or any combination of these intervals. 
     As shown in example 1, such a premix has strong antioxidative properties and can be used, optionally in combination with selenium as an antioxidant in feed and feed premixes or as a replacement or partial replacement of antibiotics in animal feed. 
     The Invention Comprising the Following Aspects and Embodiments: 
     
         
         1. An isolated polypeptide having superoxide dismutase activity selected from the group consisting of:
       a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 1;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 2;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 3;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 4;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 9;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 10;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 11;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 12;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 13;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 14;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 15;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 16;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 17;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 19;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 20;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 21;   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 22;   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 23;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 24;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 25;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 26;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 27;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 28;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 29;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 30;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 31;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 32;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 33;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 34;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 36;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 38;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 39;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 42;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 43;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 44;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 45;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 46;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 47; and   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 48;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:199;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:200;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 201;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:202;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:203;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:204;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 205;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:206;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:207;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:208;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:209;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:232;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:233;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:234;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:235;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:236; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:237.   
     
         2. An isolated polypeptide having superoxide dismutase activity comprising an amino acid sequence selected from the group consisting of:
       a. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 1;   b. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 2;   c. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 3;   d. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 4;   e. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 9;   f. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 10;   g. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 11;   h. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 12;   i. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 13;   j. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 14;   k. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 15;   l. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 16;   m. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 17;   n. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 19;   o. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 20;   p. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 21;   q. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 22;   r. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 23;   s. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 24;   t. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100 sequence identity to the amino acid sequence of SEQ ID NO: 25;   u. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 26;   v. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 27;   w. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 28;   x. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 29;   y. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 30;   z. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 31;   aa. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 32;   bb. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 33;   cc. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 34;   dd. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 36;   ee. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 38;   ff. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 39;   gg. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;   hh. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;   ii. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 42;   jj. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 43;   kk. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 44;   ll. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 45;   mm. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 46;   nn. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 47; and   oo. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 48;   pp. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:199;   qq. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:200;   rr. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO 201;   ss. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:202;   tt. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:203;   uu. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:204;   vv. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 205;   ww. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:206;   xx. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:207;   yy. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:208;   zz. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:209;   aaa. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:232;   bbb. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:233;   ccc. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:234;   ddd. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:235;   eee. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:236; and   fff. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:237.   
     
         3. An isolated polypeptide having superoxide dismutase activity selected from the group consisting of
       a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 83;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 84;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 85;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 86;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 49;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 50;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 51;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 52;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 53;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 54;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 55;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 56;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 18;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 57;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 58;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 59,   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 60,   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 61;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 62;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 63;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 64;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 65;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 66;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 67;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 68;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 69;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 70;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 71;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 35;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 37;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 72;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 73;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 74;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 75;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 76;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 77;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 78;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 79;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 80;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 81;   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 82;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 210;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 211;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 212;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 213;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 214;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 215;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 216;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 217;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 218;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 219;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 220;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 238;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 239;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 240;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 241;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 242; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 243.   
     
         4. An isolated polypeptide of having superoxide dismutase activity selected from the group consisting of
       a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 307 of SEQ ID NO 83;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 206 of SEQ ID NO 84;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 17 to 154 of SEQ ID NO 85;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 188 of SEQ ID NO 86;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 247 of SEQ ID NO 49;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 184 of SEQ ID NO 50;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 249 of SEQ ID NO 51;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 178 of SEQ ID NO 52;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 248 of SEQ ID NO 53;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 186 of SEQ ID NO 54;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 274 of SEQ ID NO 55;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 26 to 257 of SEQ ID NO 56;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 23 to 261 of SEQ ID NO 18;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 247 of SEQ ID NO 57;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 269 of SEQ ID NO 58;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 151 of SEQ ID NO 59,   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 33 to 228 of SEQ ID NO 60,   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 37 to 233 of SEQ ID NO 61;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 33 to 227 of SEQ ID NO 62;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 34 to 230 of SEQ ID NO 63;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 233 of SEQ ID NO 64;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 25 to 227 of SEQ ID NO 65;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 211 of SEQ ID NO 66;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 218 of SEQ ID NO 67;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 218 of SEQ ID NO 68;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 17 to 182 of SEQ ID NO 69;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 185 of SEQ ID NO 70;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 185 of SEQ ID NO 71;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 280 of SEQ ID NO 35;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 30 μL of SEQ ID NO 37;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 310 of SEQ ID NO 72;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 303 of SEQ ID NO 73;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 186 of SEQ ID NO 74;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 186 of SEQ ID NO 75;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 209 of SEQ ID NO 76;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 209 of SEQ ID NO 77;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 22 to 183 of SEQ ID NO 78;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 193 of SEQ ID NO 79;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 177 of SEQ ID NO 80;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 280 of SEQ ID NO 81;   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 23 to 215 of SEQ ID NO 82;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 181 of SEQ ID NO 210;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 181 of SEQ ID NO 211;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 182 of SEQ ID NO 212;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 20 to 154 of SEQ ID NO 213;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 154 of SEQ ID NO 214;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 154 of SEQ ID NO 215;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 1 to 150 of SEQ ID NO 216;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 247 of SEQ ID NO 217;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 154 of SEQ ID NO 218;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 316 of SEQ ID NO 219;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 21 to 193 of SEQ ID NO 220;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 186 of SEQ ID NO 238;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 14 to 164 of SEQ ID NO 239;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 184 of SEQ ID NO 240;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 242 of SEQ ID NO 241;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 18 to 261 of SEQ ID NO 242; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to amino acid residues 19 to 258 of SEQ ID NO 243.   
     
         5. An isolated polypeptide of having superoxide dismutase activity selected from the group consisting of
       a. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 5;   b. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 87;   c. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 88;   d. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 89;   e. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 90;   f. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 91;   g. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 92;   h. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 93;   i. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 94;   j. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 95;   k. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 96;   l. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 97;   m. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 98;   n. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 99;   o. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 100;   p. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 101;   q. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 102;   r. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 127;   s. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 128;   t. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 129;   u. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 130;   v. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 131;   w. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 132;   x. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 133;   y. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 134;   z. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 135;   aa. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 136;   bb. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 137;   cc. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 138;   dd. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 139;   ee. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 140;   ff. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 141;   gg. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 142;   hh. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 143;   ii. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 144;   jj. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 145;   kk. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 146;   ll. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 147;   mm. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 148;   nn. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 149;   oo. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 150;   pp. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 221;   qq. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 222;   rr. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 223;   ss. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 224;   tt. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 225;   uu. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 226;   vv. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 227;   ww. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of 228;   xx. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 229;   yy. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 230;   zz. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 231;   aaa. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 244;   bbb. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO SEQ ID NO 245;   ccc. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 246;   ddd. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 247;   eee. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 248; and   fff. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 249.   
     
         6. The polypeptide as defined in any of embodiments 1 to 5 of fungal origin. 
         7. An animal feed additive comprising a polypeptide of fungal origin having superoxide dismutase activity. 
         8. The animal feed additive according to claim  1  further comprising a catalase. 
         9. The animal feed additive according to claim  1  comprising an enzyme component, wherein the enzyme component comprises all of the enzymes of the additive and the enzyme component consists of a superoxide dismutase of fungal origin and optionally of a catalase. 
         10. An animal feed additive comprising at least one and no more than two enzyme classes, wherein the at least one enzyme class is a superoxide dismutase of fungal origin and the optional second enzyme class is a catalase. 
         11. The animal feed additive according to any of embodiments 7 to 10 wherein the polypeptide having superoxide dismutase activity is as defined in any of embodiments 1 to 5. 
         12. The animal feed additive according to any of embodiments 7 to 10 wherein the polypeptide having superoxide dismutase activity is selected from the group consisting of
       a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 1;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 2;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 3;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 4;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 9;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 10;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 11;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 12;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 13;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 14;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 15;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 16;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 17;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 19;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 20;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 21;   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 22;   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 23;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 24;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 25;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 26;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 27;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 28;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 29;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 30;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 31;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 32;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 33;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 34;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 36;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 38;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 39;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 42;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 43;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 44;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 45;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 46;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 47; and   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 48;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:199;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:200;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 201;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:202;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:203;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:204;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 205;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:206;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:207;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:208;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:209;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:232;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:233;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:234;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:235;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:236; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:237.   
     
         13. The animal feed additive according to any of embodiments 7 to 10 wherein the polypeptide having superoxide dismutase activity is selected from the group consisting of:
       a. a polypeptide  Trichoderma reesei  from having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 1;   b. a polypeptide from  Aspergillus versicolor  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 2;   c. a polypeptide from  Aspergillus deflectus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 3;   d. a polypeptide from  Aspergillus egyptiacus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 4;   e. a polypeptide from  Westerdykella  sp. AS85-2 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 9;   f. a polypeptide from  Aspergillus  sp. XZ2669 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 10;   g. a polypeptide from  Preussia terricola  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 11;   h. a polypeptide from  Kionochaeta  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 12;   i. a polypeptide from  Kionochaeta  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 13;   j. a polypeptide from  Metapochonia bulbillosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 14;   k. a polypeptide from  Xylomelasma  sp. XZ0718 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 15;   l. a polypeptide from  Preussia flanaganii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 16;   m. a polypeptide from  Cladobotryum  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 17;   n. a polypeptide from  Westerdykella  sp-46156 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 19;   o. a polypeptide from  Trichoderma hamatum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 20;   p. a polypeptide from  Mycothermus thermophilus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 21;   q. a polypeptide from  Cephalotrichiella penicillata  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 22;   r. a polypeptide from  Chaetomium megalocarpum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 23;   s. a polypeptide from  Chaetomium thermophilum  var.  thermophilum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 24;   t. a polypeptide from  Humicola hyalothermophila  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 25;   u. a polypeptide from  Subramaniula anamorphosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 26;   v. a polypeptide from  Sphingobacterium  sp. T2 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 27;   w. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 28;   x. a polypeptide from  Trichoderma lixii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 29;   y. a polypeptide from  Trichoderma  sp-54723 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 30;   z. a polypeptide from  Aspergillus niveus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 31;   aa. a polypeptide from  Aspergillus templicola  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 32;   bb. a polypeptide from  Pochonia chlamydosporia  var.  spinulospora  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 33;   cc. a polypeptide from  Trichoderma  sp-44174 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 34;   dd. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 36;   ee. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 38;   ff. a polypeptide from  Trichoderma  sp-44174 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 39;   gg. a polypeptide from  Metapochonia suchlasporia  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;   hh. a polypeptide from  Metarhizium marquandii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;   ii. a polypeptide from  Diaporthe nobilis  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 42;   jj. a polypeptide from  Tolypocladium  sp. XZ2627 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 43;   kk. a polypeptide from  Aspergillus japonicus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 44;   ll. a polypeptide from  Metarhizium  sp. XZ2431 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 45;   mm. a polypeptide from  Armillaria ostoyae  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 46;   nn. a polypeptide from  Trichoderma spirale  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 47; and   oo. a polypeptide from  Aspergillus elegans  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 48;   pp. a polypeptide from  Trichoderma sinuosum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:199;   qq. a polypeptide from  Trichoderma virens  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:200;   rr. a polypeptide from  Trichoderma harzianum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 201;   ss. a polypeptide from  Fusicolla acetilerea  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:202;   tt. a polypeptide from  Plectosphaerella  sp. 1-29 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:203;   uu. a polypeptide  Mariannaea punicea  from having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:204;   vv. a polypeptide from  Penicillium oxalicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 205;   ww. a polypeptide from  Colletotrichum  sp-71086 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:206;   xx. a polypeptide from  Aspergillus  sp.  nov . XZ3202 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:207;   yy. a polypeptide from  Trichoderma parapiluliferum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:208;   zz. a polypeptide from  Aspergillus  sp.  nov . XZ3202 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:209;   aaa. a polypeptide from  Mucor  sp. XZ2651 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:232;   bbb. a polypeptide from  Rhizomucor miehei  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:233;   ccc. a polypeptide from  Mucor  sp. XZ2651 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:234;   ddd. a polypeptide from Amphisphaeriaceae -sp 43674 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:235;   eee. a polypeptide from  Humicola fuscoatra  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:236; and   fff. a polypeptide from  Valsaria rubricosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:237.   
     
         14. The animal feed additive according to any of embodiments 7 to 10 wherein the polypeptide having superoxide dismutase activity comprises an amino acid sequence selected from the group consisting of:
       a. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 1;   b. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 2;   c. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 3;   d. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 4;   e. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 9;   f. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 10;   g. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 11;   h. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 12;   i. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 13;   j. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 14;   k. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 15;   l. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 16;   m. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 17;   n. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 19;   o. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 20;   p. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 21;   q. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 22;   r. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 23;   s. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 24;   t. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100 sequence identity to the amino acid sequence of SEQ ID NO: 25;   u. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 26;   v. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 27;   w. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 28;   x. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 29;   y. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 30;   z. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 31;   aa. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 32;   bb. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 33;   cc. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 34;   dd. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 36;   ee. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 38;   ff. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 39;   gg. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 40;   hh. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 41;   ii. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 42;   jj. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 43;   kk. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 44;   ll. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 45;   mm. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 46;   nn. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 47; and   oo. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 48;   pp. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:199;   qq. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:200;   rr. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO 201;   ss. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:202;   tt. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:203;   uu. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:204;   vv. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO: 205;   ww. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:206;   xx. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:207;   yy. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:208;   zz. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:209;   aaa. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:232;   bbb. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:233;   ccc. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:234;   ddd. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:235;   eee. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:236; and   fff. an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to the amino acid sequence of SEQ ID NO:237.   
     
         15. The animal feed additive according to any of embodiments 7 to 10 wherein the polypeptide having superoxide dismutase activity is selected from the group consisting
       a. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 83;   b. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 84;   c. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 85;   d. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 86;   e. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 49;   f. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 50;   g. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 51;   h. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 52;   i. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 53;   j. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 54;   k. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 55;   l. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 56;   m. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 18;   n. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 57;   o. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 58;   p. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 59,   q. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 60,   r. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 61;   s. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 62;   t. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 63;   u. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 64;   v. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 65;   w. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 66;   x. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 67;   y. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 68;   z. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 69;   aa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 70;   bb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 71;   cc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 35;   dd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 37;   ee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 72;   ff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 73;   gg. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 74;   hh. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 75;   ii. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 76;   jj. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 77;   kk. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 78;   ll. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 79;   mm. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 80;   nn. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 81;   oo. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 82;   pp. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 210;   qq. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 211;   rr. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 212;   ss. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 213;   tt. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 214;   uu. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 215;   vv. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 216;   ww. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 217;   xx. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 218;   yy. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 219;   zz. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 220;   aaa. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 238;   bbb. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 239;   ccc. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 240;   ddd. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 241;   eee. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 242; and   fff. a polypeptide having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 243.   
     
         16. The animal feed additive according to any of embodiments 7 to 10 wherein the polypeptide having superoxide dismutase activity is selected from the group consisting of
       a. a polypeptide from  Trichoderma reesei  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 83;   b. a polypeptide from  Aspergillus versicolor  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 84;   c. a polypeptide from  Aspergillus deflectus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 85;   d. a polypeptide from  Aspergillus egyptiacus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 86;   e. a polypeptide from  Westerdykella  sp. AS85-2 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 49;   f. a polypeptide from  Aspergillus  sp. XZ2669 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 50;   g. a polypeptide from  Preussia terricola  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 51;   h. a polypeptide from  Kionochaeta  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 52;   i. a polypeptide from  Kionochaeta  sp. having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 53;   j. a polypeptide from  Metapochonia bulbillosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 54;   k. a polypeptide from  Xylomelasma  sp. XZ0718 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 55;   l. a polypeptide from  Preussia flanaganii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 56;   m. a polypeptide from  Cladobotryum  sp having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 18;   n. a polypeptide from  Westerdykella  sp-46156 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 57;   o. a polypeptide from  Trichoderma hamatum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 58;   p. a polypeptide from  Mycothermus thermophilus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 59,   q. a polypeptide from  Cephalotrichiella penicillata  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 60,   r. a polypeptide from  Chaetomium megalocarpum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 61;   s. a polypeptide from  Chaetomium thermophilum  var.  thermophilum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 62;   t. a polypeptide from  Humicola hyalothermophila  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 63;   u. a polypeptide from  Subramaniula anamorphosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 64;   v. a polypeptide from  Sphingobacterium  sp. T2 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 65;   w. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 66;   x. a polypeptide from  Trichoderma lixii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 67;   y. a polypeptide from  Trichoderma  sp-54723 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 68;   z. a polypeptide from  Aspergillus niveus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 69;   aa. a polypeptide from  Aspergillus templicola  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 70;   bb. a polypeptide from  Pochonia chlamydosporia  var.  spinulospora  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 71;   cc. a polypeptide from  Trichoderma  sp-44174 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 35;   dd. a polypeptide from  Trichoderma rossicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 37;   ee. a polypeptide from  Trichoderma  sp-54723 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 72;   ff. a polypeptide from  Trichoderma  sp-44174 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 73;   gg. a polypeptide from  Metapochonia suchlasporia  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 74;   hh. a polypeptide from  Metarhizium marquandii  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 75;   ii. a polypeptide from  Diaporthe nobilis  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 76;   jj. a polypeptide from  Tolypocladium  sp. XZ2627 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 77;   kk. a polypeptide from  Aspergillus japonicus  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 78;   ll. a polypeptide from  Metarhizium  sp. XZ2431 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 79;   mm. a polypeptide from  Armillaria ostoyae  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 80;   nn. a polypeptide from  Trichoderma spirale  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 81;   oo. a polypeptide from  Aspergillus elegans  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 82;   pp. a polypeptide from  Trichoderma sinuosum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 210;   qq. a polypeptide from  Trichoderma virens  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 211;   rr. a polypeptide from  Trichoderma harzianum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 212;   ss. a polypeptide from  Fusicolla acetilerea  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 213;   tt. a polypeptide from  Plectosphaerella  sp. 1-29 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 214;   uu. a polypeptide from  Mariannaea punicea  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 215;   vv. a polypeptide from  Penicillium oxalicum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 216;   ww. a polypeptide from  Colletotrichum  sp-71086 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 217;   xx. a polypeptide from  Aspergillus  sp.  nov . XZ3202 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 218;   yy. a polypeptide from  Trichoderma parapiluliferum  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 219;   zz. a polypeptide from  Aspergillus  sp.  nov . XZ3202 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 220;   aaa. a polypeptide from  Mucor  sp. XZ2651 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 238;   bbb. a polypeptide from  Rhizomucor miehei  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 239;   ccc. a polypeptide from  Mucor  sp. XZ2651 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 240;   ddd. a polypeptide from Amphisphaeriaceae -sp 43674 having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 241;   eee. a polypeptide from  Humicola fuscoatra  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 242; and   fff. a polypeptide from  Valsaria rubricosa  having at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 243.   
     
         17. The animal feed additive according to any of embodiments 7 to 10 comprising one or more polypeptides having superoxide dismutase (SOD) activity wherein the polypeptide having superoxide dismutase activity is selected from the group consisting of:
       a. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 5;   b. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 87;   c. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 88;   d. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 89;   e. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 90;   f. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 91;   g. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 92;   h. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 93;   i. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 94;   j. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 95;   k. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 96;   l. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 97;   m. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 98;   n. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 99;   o. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 100;   p. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 101;   q. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 102;   r. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 127;   s. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 128;   t. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 129;   u. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 130;   v. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 131;   w. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 132;   x. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 133;   y. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 134;   z. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 135;   aa. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 136;   bb. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 137;   cc. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 138;   dd. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 139;   ee. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 140;   ff. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 141;   gg. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 142;   hh. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 143;   ii. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 144;   jj. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 145;   kk. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 146;   ll. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 147;   mm. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 148;   nn. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 149;   oo. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 150;   pp. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 221;   qq. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 222;   rr. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 223;   ss. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 224;   tt. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 225;   uu. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 226;   vv. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 227;   ww. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of 228;   xx. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 229;   yy. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 230;   zz. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 231;   aaa. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 244;   bbb. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO SEQ ID NO 245;   ccc. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 246;   ddd. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 247;   eee. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 248; and   fff. a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity to the polypeptide coding sequence of SEQ ID NO 249.   
     
         18. The animal feed additive according to any of embodiments 7 to 17 wherein the feed additive comprises one or more polypeptides having catalase activity and/or further comprising one or more vitamins. 
         19. The animal feed additive of embodiment 18, wherein the one or more vitamins is a fat-soluble vitamin, preferably vitamin E. 
         20. The animal feed additive according to any of claims  7  to  19 , wherein the polypeptide having catalase activity is selected from the group consisting of:
       a. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 6; and   b. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 7;   c. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 103;   d. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 104;   e. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 105;   f. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 106;   g. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 107;   h. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 108;   i. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 109;   j. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 110;   k. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 111;   l. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 112;   m. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 113;   n. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 114;   o. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 115;   p. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 116;   q. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 117;   r. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 118;   s. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 119;   t. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 120;   u. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 121;   v. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 122;   w. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 123;   x. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 124;   y. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 125;   z. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 126; and   aa. a polypeptide having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 127.   
     
         21. A method of improving one or more performance parameters in an animal comprising administering to the animal an animal feed or animal feed additive comprising one or more polypeptides having superoxide dismutase (SOD) activity of fungal origin, wherein the one or more performance parameters is selected from the group consisting of the European Production Efficiency Factor (EPEF), Feed Conversion Ratio (FCR), Growth Rate (GR), Body Weight Gain (WG), Mortality Rate (MR) and Flock Uniformity (FU). 
         22. A method of improving or enhancing immune response and/or reducing inflammation and/or for the modulation of the gut flora in an animal comprising administering to the animal an animal feed or animal feed additive comprising one or more polypeptides having superoxide dismutase activity of fungal origin. 
         23. A method of reducing or eliminating the use of antibiotics administered to an animal feed, comprising administering to the animal an animal feed or animal feed additive comprising of one or more polypeptides having superoxide dismutase activity of fungal origin. 
         24. The method according to any of embodiments 21 to 23, wherein the animal has experienced heat stress, cold stress, nutritional stress and/or oxidative stress. 
         25. The method of embodiments 21 to 24 to reduce cellular markers of reactive oxygen species or free radicals. 
         26. The method of any of embodiments 21 to 25, wherein the polypeptide having superoxide dismutase activity is an EC 1.15.1.1 super oxide dismutase (SOD) of fungal origin. 
         27. The method of any of embodiments 21 to 26, wherein the polypeptide having superoxide dismutase activity is as defined in any of embodiments 1 to 6. 
         28. The method of any of embodiments 21 to 27, wherein the polypeptide having superoxide dismutase (SOD) activity is selected from the group consisting of a Cu-SOD, a Zn-SOD, a Mn-SOD, and an Fe-SOD. 
         29. The method according to any of embodiments 21 to 28, wherein the animal feed or animal feed additive further comprises one or more polypeptides having catalase activity. 
         30. The method according to any of embodiments 21 to 28, wherein the polypeptide having catalase activity is classified as an EC 1.11.1.6 catalase or as an EP 1.11.1.21 catalase peroxidase. 
         31. The method according to any of embodiments 21 to 30, wherein the polypeptide having catalase activity is selected from the group consisting of:
       a. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 6; and   b. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 7   c. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 103   d. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 104;   e. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 105;   f. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 106;   g. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 107;   h. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 108;   i. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 109   j. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 110   k. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 111   l. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 112   m. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 113   n. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 114   o. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 115   p. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 116   q. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 117   r. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 118   s. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 119   t. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 120   u. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 121   v. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 122   w. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 123   x. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 124   y. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 125   z. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 126;   aa. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 250;   bb. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 151;   cc. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 152;   dd. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 153;   ee. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 154;   ff. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 155;   gg. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 156;   hh. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 157;   ii. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 158;   jj. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 159;   kk. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 160;   ll. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 161;   mm. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 162;   nn. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 163;   oo. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 164;   pp. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 165;   qq. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 166;   rr. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 167;   ss. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 168;   tt. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 169;   uu. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 170;   vv. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 171;   ww. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 172;   xx. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 173;   yy. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 174; and   zz. a polypeptide with catalase activity having at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO 251.   
     
         32. Use of an animal feed additive as defined in any of embodiments 7 to 20 as an antioxidant, preferably in feed and feed premixes. 
         33. Use of an animal feed additive as defined in any of embodiments 7 to 20 for replacing or partially replacing antibiotics in animal feed. 
         34. An animal feed comprising one or more protein sources and one or more energy sources characterised in that the animal feed further comprises one or more polypeptides having superoxide dismutase (SOD) activity, wherein the animal feed
       a. improves or enhances immune response; or   b. reduces inflammation;   when fed to the animal as compared to animals fed a feed composition without the polypeptides; and
 
said feed optionally further comprising one or more polypeptides having catalase activity.
   
     
       
    
     EXAMPLES 
     Example 1: Heat Stress Model in Broilers: SOD and CAT Reduce Oxidative Stress Response 
     Background 
     Different stress factors inevitably influence the animal&#39;s physiology and performance with varying degrees during the production period. High ambient temperature is one of the most common stressor in modern poultry production resulting in reduced feed intake, body weight gain, and increased mortality. Because of their physiological state and greater metabolic activity, broilers are more susceptible to temperature associated environmental challenges. In addition to its effect on bird performance, the adverse effects of heat stress can range from minimal discomfort to multi-organ damage and failure, including alteration of gut permeability and function due to weakened tight junctions of the epithelial layer. Therefore, heat stress-induced disturbance of gut integrity may lead to leaky gut syndrome thus increasing the susceptibility of birds to enteric pathogens that may lead to systemic bacterial infections. Moreover, heat stress can cause oxidative damage by increasing the formation of reactive oxygen species. 
     Hypothesis and Objective 
     The central hypothesis is that the adverse effects of heat stress on performance and health of chickens can be mitigated by incorporating effective feed additives into poultry diets. Certain compounds that can alter the dysregulating effects of heat stress may help in maintaining gut integrity and function. Therefore, the main objective is to alleviate the impact of heat stress challenge on performance and overall health of broilers by timely supplementation of non-drug dietary additives. 
     Experimental Design 
     A 35-day trial with only male broiler chicks will be run in floor pens with eight replicate pens per treatment and 20 birds/pen. Birds are randomly assigned to treatment groups in a 2×4 factorial arrangement that includes heat stress (optimal or high heat) and dietary treatments (basal diet or feed additives) as per  FIG. 1 . A total of 4 animal rooms are used (2 controls and 2 heat stress) each housing half the replicate pens (n=4) per group. 
     Three birds per pen for each of the three sampling times (3×3=9) are randomly tagged at placement with necktags of different colour (or number) per sampling time to ensure random sampling. At sampling, the two of the three birds with the closest to average BW are selected for sampling and their BW is recorded. If less than two of those birds are available or healthy, other random birds can be selected in the pen to complete the two sampled birds. 
     Treatment groups including controls and challenge from d 28 to 35 (heat stress) are as follows: 
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Treatment groups 
               
            
           
           
               
               
               
            
               
                   
                   
                 Heat Stress 
               
               
                   
                   
                 Challenge 
               
               
                 Treatment 
                 Description 
                 d 28-35 
               
               
                   
               
               
                 1. NC 
                 Negative Control (NC) = basal 
                 −−− 
               
               
                   
                 diets (corn/soy) 
               
               
                 2. VitE + Se 
                 NC + Vit E + Se (d 0-35) 
                 −−− 
               
               
                 3. Mix Low 
                 NC + SOD SEQ: ID 1 500 U/kg + 
                 −−− 
               
               
                   
                 CAT SEQ ID: 7 .100 U/kg (d 0-35) 
               
               
                 4. Mix High 
                 NC + SOD SEQ: ID 1 500 U/kg + 
                 −−− 
               
               
                   
                 CAT SEQ ID: 7, 500 U/kg (d 0-35) 
               
               
                 5. PC 
                 Positive Control: NC + heat 
                 +++ 
               
               
                   
                 stress d 28-35 
               
               
                 6. VitE + Se 
                 PC + Vit E + Se (d 0-35) 
                 +++ 
               
               
                 7. Mix Low 
                 PC + SOD SEQ ID 1, 500 U/kg + 
                 +++ 
               
               
                   
                 CAT SEQ ID: 7, 100 U/kg (d 0-35) 
               
               
                 8. Mix High 
                 PC + SOD SEQ: ID 1, 500 U/kg + 
                 +++ 
               
               
                   
                 CAT SEQ ID: 7, 500 U/kg (d 0-35) 
               
               
                   
               
               
                 *PC: Vit E - 250 mg/kg; SePlex - 1 mg/kg 
               
               
                 **NC: Vit E - 10 mg/kg; SePlex - 0.14 mg/kg 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Treatment identification and doses 
               
            
           
           
               
               
            
               
                 Treatment 
                 Application 
               
               
                   
               
               
                 VitE + Se 
                 Dry, applied in mixer 
               
               
                   
                 Vitamin E: 250 mg/kg (ROVIMIX ® E50) 
               
               
                   
                 Selenium: 1 mg Se/kg (Sel-Plex ®) 
               
               
                 Mix Low 
                 Liquid, gently mix the products with distilled water to 
               
               
                   
                 complete a total of 1,000 ml/MT (100 ml/100 kg feed) 
               
               
                   
                 immediately before application, and spray uniformly into 
               
               
                   
                 the mixer, directly into the feed with a micro-fluid nozzle 
               
               
                   
                 applicator 
               
               
                   
                 SOD: 80 ml/MT (8 ml/100 kg) 
               
               
                   
                 CAT: 4 ml/MT (0.4 ml/100 kg) 
               
               
                 Mix High 
                 Liquid, gently mix the products with distilled water to 
               
               
                   
                 complete a total of 1,000 ml/MT (100 ml/100 kg feed) 
               
               
                   
                 immediately before application, and spray uniformly into 
               
               
                   
                 the mixer, directly into the feed with a micro-fluid nozzle 
               
               
                   
                 applicator 
               
               
                   
                 SOD: 80 ml/MT (8 ml/100 kg) 
               
               
                   
                 CAT: 20 ml/MT (2 ml/100 kg) 
               
               
                   
               
            
           
         
       
     
     Handling of Products 
     
         
         
           
             Store refrigerated at 4 C. 
             Gently mix before applying. 
             Use industrial protective equipment for handling: gloves, mask, googles, and coat. 
             Mix with distilled water at room temperature to complete 1,000 ml/MT immediately before application, and spray uniformly in the mixer, directly into the feed with a micro-fluid nozzle applicator. 
           
         
       
    
     Heat Stress Protocol 
     Heat stress protocol is performed as planned during the finisher feeding phase (d 28 to d 35). For the heat stress groups, temperature is maintained at 35±1° C. (10° C. above the recommended temp.) and applied once daily from 10 am to 2 μm, then reduced again to 25 C+/−1 for the remainder of the day. Relative humidity is monitored and maintained at RH&lt;50%. Birds in the separate ‘optimal heat’ group are kept under normal constant recommended temperatures (25° C.+/−1). The birds&#39; (2 birds/pen) rectal temperature was monitored daily with a rectal probe during the heat stress period (d 28-35). 
     Feed 
     The diets consist of corn/soybean in mash as Starter (d 1-21) and Grower (d 22-35) and will be formulated according to commercial specifications for the broilers used (Ross or Cobb) to meet or exceed NRC recommendations (Table 4). Test products are sprayed onto a small amount (20 kg) of the basal diet and mixed with the rest of the batch for each diet. 
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 Basal diet formulation for Starter and Grower phases. 
               
            
           
           
               
               
               
            
               
                   
                 Basal Diet 
                   
               
            
           
           
               
               
               
            
               
                   
                 0-21 d 
                 22-35 d 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Ingredient, g/kg 
                   
                   
               
               
                   
                 Corn 
                 558.80 
                 618.20 
               
               
                   
                 Soybean meal, CP 48% 
                 360.00 
                 297.00 
               
               
                   
                 Vegetable oil 
                 40.00 
                 52.00 
               
               
                   
                 Limestone 
                 5.00 
                 4.00 
               
               
                   
                 Dicalcium phosphate 
                 24.00 
                 19.00 
               
               
                   
                 DL-Methionine (98%) 
                 3.20 
                 2.00 
               
               
                   
                 L-Lysine HCl (78%) 
                 2.80 
                 2.00 
               
               
                   
                 L-Threonine 
                 1.30 
                 0.80 
               
               
                   
                 Salt 
                 2.50 
                 2.50 
               
               
                   
                 Vitamin premix 1   
                 1.00 
                 1.00 
               
               
                   
                 Mineral premix 2   
                 1.00 
                 1.00 
               
               
                   
                 Cholin chloride 
                 0.50 
                 0.50 
               
               
                   
                 Total 
                 1000 
                 1000 
               
               
                   
                 Chemical composition (Calculated) 
               
               
                   
                 Dry Matter, % 
                 87.95 
                 87.90 
               
               
                   
                 Crude Protein, % 
                 22.25 
                 19.50 
               
               
                   
                 AME n , kcal/kg 
                 3060 
                 3205 
               
               
                   
                 Lysine, % 
                 1.39 
                 1.15 
               
               
                   
                 Dig. Lysine, % 
                 1.23 
                 1.02 
               
               
                   
                 Methionine + cysteine, % 
                 1.00 
                 0.82 
               
               
                   
                 Dig. Methionine + cysteine, % 
                 0.90 
                 0.71 
               
               
                   
                 Threonine, % 
                 0.94 
                 0.80 
               
               
                   
                 Dig. Threonine, % 
                 0.81 
                 0.68 
               
               
                   
                 Calcium, % 
                 0.96 
                 0.78 
               
               
                   
                 Available phosphorus, % 
                 0.47 
                 0.39 
               
               
                   
                   
               
               
                   
                   1,2 Appended separately. Premix delivers 0.14 mg Se/kg, and 10 mg Vit E/kg 
               
            
           
         
       
     
     Parameters Evaluated 
     
         
         1. Performance: Standard performance parameters including body weight (BW), weight gains (BWG), feed intake (FI), and feed conversion ratios (FCR) are evaluated on days 10, 21, 27, and 35 on a per pen basis. Any mortality is recorded daily and feed consumption (+FCR) corrected for accordingly. Average bird performance is calculated based on the number of birds per each pen (i.e. replicate) after adjusting for any mortality. 
         2. Rectal temperature: The birds&#39; rectal temperature is monitored daily during the heat stress period (d 28-35). Two birds from each replicate pen are selected and tagged for body temperature measurement using a rectal probe daily at a pre-set time range (e.g. 1-2 μm). 
         3. Antioxidant parameters: Based on the stress challenge employed, blood serum and liver are sampled at 27, 28 and 35 d from two birds of average BW per pen to determine parameters related to oxidative stress:
       a. MDA, CAT, GSH-Px, and SOD: On d 27, two birds per replicate pen are tagged for blood sampling. Blood samples are taken by wing venipuncture on d 27, d 28, and d 35 (alternating sides), and collected into red-topped serum tubes. The tubes are transferred to the main lab and centrifuged at 2,000×g for 5 min to collect sera, which are stored at 20° C. until analysis. Antioxidant analyses in blood samples are carried out with commercial kits according to the manufacturer recommendations.   b. Optional analyses. Depending on the results of the other parameters, it might be decided to measure Vitamin E, vitamin A, cysteine, cystine, methionine, and glutamine in the liver, using standard HPLC protocols are used to measure vitamins A and E, as well as profile amino acids (separated on a single column). They are not included in the initial budget.   
     
         4. Liver bacterial load: At the end of the study (d 35), liver samples are collected from one bird per pen in sterile sampling bags to determine total bacterial load in liver. To establish standard curves for bacterial quantification, pure bacterial ( E. coli , and  Clostridium perfringens ) suspensions are individually cultured in corresponding selective media, the DNA extracted (commercial extraction kits), and its concentration determined (Nano-Drop). The DNA stocks are serially diluted (6 times) and real time quantitative PCR performed to determine the threshold cycle (Ct) value related to each pure sample. The standard curves are established with the DNA concentrations and corresponding relative Ct values. DNA from liver tissue samples are extracted via special kits. The abundance of DNA copies in DNA samples from liver tissue is determined by qPCR. For this purpose, specific primers for bacterial 16S rRNA gene are used, and the bacterial loads per gram tissue are calculated using the generated standard curves. 
         5. Carcass/body composition (no additional cost): Dual Energy X-Ray Absorptiometry (DXA) analysis is performed on 3 birds per pen on d 35 to assess the effects of products on various measurements of carcass/body composition. These include body fat percentage, fat tissue, lean tissue, and bone mineral density (BMD), in addition to bone mineral content (BMC) and carcass area, both used for calculation purposes. 
         6. Gene expression: Liver and intestinal (jejunum) tissue samples are taken (2/pen) on d 27, d 28 and d 35 from birds with average pen weight (sampled above for histology). Liver weight is measured and relative weight calculated per bird. Tissues are collected, minced, snap-frozen, and stored at 80° C. until qPCR analysis. Target genes to be measured include immunity-related to heat stress (oxidative stress, heat shock proteins, inflammatory markers), tight junction genes, host defense peptides, and nutrient transporters. The final list of targets is determined based on study outcome. Transcript analysis for a subset of targets is measured in each collected tissue. 
       
    
     Heat Stress Protocol 
     Heat stress protocol was performed as planned during the last week of the experiment (d 28 to d 35). For the heat stress groups, temperature was raised and maintained at 35±1° C. (10° C. above the recommended temp.) and applied once daily from 10 am to 2 pm, then reduced again to 25° C.+/−1 for the remainder of the day. Relative humidity was monitored and maintained at RH&lt;50%. Birds in the separate ‘optimal heat’ group were kept under normal constant recommended temperatures (25° C.+/−1). The birds&#39; (2 birds/pen) rectal temperature was monitored daily with a rectal probe during the heat stress period (d 28-35). 
     Sampling Procedures 
     Blood, liver and intestinal (jejunum) tissue samples were taken on d 27 (1/pen), d 28 (2/pen) and d 35 (2/pen) from birds with average pen weight for qPCR and antioxidant assay analyses. The livers were weighed and observed for any pathological findings. 
     DXA Analysis 
     Dual Energy X-Ray Absorptiometry (DXA) analysis was performed on 2 birds per pen on d 35 to assess various measurements of carcass/body composition. Birds were individually wing-banded, sacrificed by cervical dislocation and subsequently defeathered and carcasses stored at −20° C. until DXA analysis. Birds were thawed and 10 birds were scanned at a time using GE Healthcare Lunar Prodigy Advance, System ID PA+130,744 (GE, Madison, Wis.). 
     Total RNA Extraction and Reverse Transcription 
     Total RNA was extracted from individual liver and intestinal tissues using the Direct-zol RNA Kits (Zymo Research) according to the manufacturer&#39;s recommendations. Tissue samples were removed from −80° C. and placed on ice. A 20-30 mg aliquot of each sample was weighed, placed into a 2-mL microcentrifuge tube, and kept on ice until homogenization. Total RNA concentration was determined at optical density (OD) of 260 (NanoDrop-1000, Thermo Fisher Scientific, Waltham, Mass.), and RNA purity was verified by evaluating the 260/280 OD ratios. Total RNA was diluted to 0.2 μg/μL in nuclease-free water. Reverse transcription was accomplished using the high capacity cDNA Reverse Transcription kit (Applied Biosystems, Carlsbad, Calif.) following the manufacturer&#39;s protocol and the cDNA was stored at 20° C. 
     Quantitative Real-Time PCR 
     Quantitative real-time PCR (qRT-PCR) was performed using an ABI 7500 Fast Real-Time PCR System (Applied Biosystems). The cDNA was diluted 1:20 in nuclease-free water, and 1 μL of the diluted cDNA was added to each well of a 96-well plate. Next, 9 μL of RT-PCR master mix containing 5 μL of Fast SYBR Green Master Mix (Applied Biosystems), 0.5 μL each of 2 μM forward and reverse primers, and 3 μL of sterile nuclease-free water per reaction were added to each well for a final volume of 10 μL. During the PCR reaction, samples were subjected to an initial denaturation phase of 95° C. for 20 s followed by 40 cycles of denaturation at 95° C. for 3 s and annealing and extension at 60° C. for 30 s. Gene expression was analyzed using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as an endogenous control. Each reaction was run in duplicate. Results from qRT-PCR were analyzed using the 7500 Real-Time PCR software (Applied Biosystems). The primer pairs used are shown in Table 4. Average gene expression relative to the GAPDH endogenous control for each sample was calculated using the 2 −ΔΔct  method (Livak and Schmittgen, 2001). 
     Antioxidant Analysis 
     Based on the stress challenge employed, blood serum and liver samples were analyzed to determine thiobarbituric acid reactive substances (TBARS), catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities on d 27, d 28 and d 35. Antioxidant analyses were carried out with commercial assay kits (Cayman, Ann Arbor, Mich.). 
     Statistical Analysis 
     Data were subjected to a 2-way ANOVA using the GLM procedure of JMP (Pro13). The models included heat stress (optimal and high heat) and dietary treatments (basal diet or feed additives) as the main factors, and the 2-way interactions. Post hoc testing was only carried out for significant interactions and was performed using simple effect analysis. The probability P&lt;0.05 was considered significant unless otherwise noted. 
     
       
         
           
               
             
               
                 TABLE 5  
               
             
            
               
                   
               
               
                 Primer sequences for qPCR analysis. 
               
            
           
           
               
               
               
            
               
                 Target Gene 
                 Forward 
                 Reverse 
               
               
                   
               
               
                 Intestinal tissue: 
                   
                   
               
               
                 Occludin 
                 TCATCGCCTCCATCGTCTAC 
                 TCTTACTGCGCGTCTTCTGG 
               
               
                 ZO-1 
                 TGTAGCCACAGCAAGAGGTG 
                 CTGGAATGGCTCCTTGTGGT 
               
               
                 Muc-2 
                 CAGCACCAACTTCTCAGTTC 
                 TCTGCAGCCACACATTCTTT 
               
               
                 TFF-2 
                 TGGTCCCCCAGGAATCTCA 
                 CACCGACGCATTGAAGCA 
               
               
                 PepT1 
                 CCCCTGAGGAGGATCACTGTT 
                 CAAAAGAGCAGCAGCAACGA 
               
               
                 SI 
                 CGCAAAAGCACAGGGACAGT 
                 TCGATACGTGGTGTGCTCAGTT 
               
               
                 IAP 
                 GAGCCTACACCAGCATCCTC 
                 GCTGCCTGTAGTCCTTGTCC 
               
               
                 NaPi-Ilb 
                 GAAAGTGGTGAAGATGCC 
                 AAGTATGAGACCGATGGC 
               
               
                 SG LT-1 
                 GGGACAGTAGGTGGATTCTTT 
                 CACCAATCGGCCACCAA 
               
               
                   
                 CTG 
                   
               
               
                   
               
               
                 Liver: 
                   
                   
               
               
                 CAT 
                 TGAAGCGGTGGCAAAGC 
                 GCCAGCACCAGTGGTCAAG 
               
               
                 GSH-Px 
                 TTGTAAACATCAGGGGCAAA 
                 TGGGCCAAGATCTTTCTGTAA 
               
               
                 SOD 
                 AGGGGGTCATCCACTTCC 
                 CCCATTTGTGTTGTCTCCAA 
               
               
                 GST 
                 GCCTGACTTCAGTCCTTGGT 
                 CCACCGAATTGACTCCATCT 
               
               
                   
               
               
                 Intestine &amp; liver: 
                   
                   
               
               
                 IL-1β 
                 CACAGAGATGGCGTTCGTTC 
                 GCAGATTGTGAGCATTGGGC 
               
               
                 IL-4 
                 GCTCTCAGTGCCGCTGATG 
                 GAAACCTCTCCCTGGATGTCAT 
               
               
                 IL-6 
                 TTCGACGAGGCAAGGAACC 
                 AGGTCTGAAAGGCGAACAGG 
               
               
                 IL-10 
                 GCTCTCCTTCCACCGAAACC 
                 GGAGCAAAGCCATCAAGCAG 
               
               
                 TLR-2 
                 GCGAGCCCCCACGAA 
                 GGAGTCGTTCTCACTGTAGGAGACA 
               
               
                 TLR-4 
                 TCCGTGCCTGGAGGTAAGT 
                 TGCCTTGGTAACAGCCTTGA 
               
               
                 LITAF 
                 TGTTCTATGACCGCCCAGTTC 
                 AGACGTGTCACGATCATCTGGTTA 
               
               
                 iNOS 
                 CCTGTACTGAAGGTGGCTATT 
                 AGGCCTGTGAGAGTGTGCAA 
               
               
                   
                 GG 
                   
               
               
                 IFN-Y 
                 GCATCTCCTCTGAGACTGGC 
                 GCTCTCGGTGTGACCTTTGT 
               
               
                 HSP70 
                 CATCAAGCGTAACACCACCATT 
                 CCAGCAAGTTGTTGTCCTTTGTCATA 
               
               
                   
                 CC 
                   
               
               
                 HSP90AA1 
                 AGAAAAGGTTGTTGTGTCCAAT 
                 CAGCCTCTGCCTTCTGCCTCA 
               
               
                   
                 CGC 
                   
               
               
                 Lysozyme 
                 GAAGCGTCACGGACTTGATAA 
                 CCCATCGGTGTTACGGTTTG 
               
               
                   
                 CTA 
                   
               
               
                   
               
               
                 Housekeeping 
                 House Keeping genes 
                   
               
               
                 β-actin 
                 CAACACAGTGCTGTCTGGTGG 
                 ATCGTACTCCTGCTTGCTGATCC 
               
               
                   
                 TA 
                   
               
               
                 GAPDH 
                 CCTAGGATACACAGAGGACCA 
                 GGTGGAGGAATGGCTGTCA 
               
               
                   
                 GGTT 
               
               
                   
               
               
                 *Not including host defense peptides. 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 Sampling schedule 
               
            
           
           
               
               
               
               
            
               
                 Time point 
                 # of birds 
                 Samples 
                 Analyses 
               
               
                   
               
               
                 27 d, 28 d 
                 128/day 
                 Blood 
                 Antioxidant parameters 
               
               
                 and 35 d; 
                 (2 birds 
                 serum 
               
               
                 start at 2pm 
                 per pen) 
                 Liver 
                 Antioxidant parameters, gene 
               
               
                   
                   
                   
                 expression (oxidative, immune 
               
               
                   
                   
                   
                 genes); bacterial load at d 35 
               
               
                   
                   
                 Jejunal 
                 gene expression (oxidative, immune, 
               
               
                   
                   
                 mucosa 
                 nutritional, gut integrity genes) 
               
               
                   
               
            
           
         
       
     
     Results 
     Experimental results are shown in  FIGS. 1 to 15  and can be summarized as follows: 
     Performance Parameter: 
     Performance parameter are shown in 
     FIG.  1 : BWG, d 0-35 
     FIG.  2 : FCR, d 0-35 
     FIG.  3 : Mortality, d 0-35 
     FIG.  4 : BWG 27-35 d 
     FIG.  5 : FCR 27-35 d 
     FIG.  6 : Mortality 27-35 d 
     FIG.  7 : BWG 0-7 d 
     FIG.  8 : FCR 0-7 d 
     
         
         
           
             There was an effect of SOD 400+CAT 100 on BW gain and feed intake in the overall period. 
             A high performance effect of enzymes on BWG and FCR was present in the first week. As reported in  FIGS. 7 &amp; 8 , body weight gain (BWG) and feed conversion ratio (FCR) were improved in birds fed the diets containing either Pro. Low (T3&amp;T7) or Pro. High (T4&amp;T8) compared to birds fed the control diet. 
             Feed intake (FI) and mortality were not affected among the treatment groups during the first week (d 0-7). In particular, a numeric reductions in mortality during heat stress and over the entire trial could be observed. 
             Birds fed the diets containing Vit E+Se, Pro. Low, and Pro. High had higher Feed intake compared to the control group and also tended to have higher BWG between d 7-14. Similarly, BW and FI were higher in birds fed those diets containing Vit E+Se, Pro. Low, and Pro. High between d 0-14. 
             Birds fed antioxidant enzymes or Vit E &amp; Se did not perform better during heat stress. However, numerically there was less mortality in birds fed antioxidants (enzymes or Vit E&amp; Se) compared to the control during HS. 
           
         
       
    
     The data presented above show that an animal feed additive comprising at least one or more polypeptides according to the present invention improves one or more performance parameters selected from the group consisting of
         Feed Conversion Ratio (FCR),   Growth Rate (GR), Body Weight Gain (WG),   Mortality Rate (MR).       

     Other Parameters: 
     With respect to markers for oxidative and cellular stress and immune function a significant interaction was observed in the HSP90 gene expression between dietary and heat stress treatments. In particular, the heat challenge significantly upregulated the expression of GPx, SOD, HSP70, HSP90, and TLR4, and downregulated that of GST, IL-10, TNFα, and IFNγ in the liver on d 27/28. 
     A) Liver Gene Expression 
     The dietary treatments had significant increase in liver GPx (pre-heat stress) with the lowest doses of enzymes ( FIG. 9 —liver GPx, nmol/min/mL (measured day 27)) 
     B) Measurement of Heat Shock Proteins (HSP), which are Indicators of Cellular Stress. 
     With respect to HSP
         a significant reduction of jejunum gene expression of HSP70 ( FIG. 10 —(day 28)) and liver gene expression of HSP70 ( FIG. 11 —(day 35)) during heat stress at the lowest dose of enzymes and   a numeric reduction in liver gene expression of HSP90 during heat stress was observed.
 
C) Immune function.
       

     The enzyme according to the present invention also show a positive effect on immune function. The treatments show a significant reduction of liver iNOS prior to heat stress challenge ( FIG. 12 —liver iNOS (mediator of inflammation) pre-heat stress (d 27)) or TLR2, IL-1B, IL-10, TNFa, and INFy ( FIG. 13 —liver gene expression of IL-10 (anti-inflammatory) during heat stress (d 35);  FIG. 14 —liver gene expression of TNF alpha (pro-inflammatory) during heat stress (d 35);  FIG. 15  liver gene expression of INF gamma (pro-inflammatory) during heat stress (d 35)). 
     The results on all these other parameters clearly show that the enzymes according to the present invention help
         to reduce
           heat-, cold-, nutritional- and oxidative stress,   cellular markers of reactive oxygen species or free radicals,   inflammation and   
           to improve or enhance immune response in the animal.       

     Example 2: Nutritional Model in Piglets 
     Experimental Unit: Slatted Floor Pens, 4 piglets per pen (2 barrows &amp; 2 gilts per pen) 
     Feed Type: Starter (Day 0-21) and Grower (Day 21-42). MASH feed is employed, using a corn-soybean type commercial ration formulation with an increase of 5-6% crude protein compared to normal commercial rations. Test material is added to the feed beginning on Day 0 and continuing through Day 42. 
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 Treatments (Days 0-42) 
               
            
           
           
               
               
               
            
               
                   
                 SOD (U/kg) 
                 CAT (U/kg) 
               
               
                 Treatments 
                 SEQ ID NO: 1 
                 SEQ ID NO: 7 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Positive Control (PC)* 
                 0 
                 0 
               
               
                 Negative Control (NC, 22% CP) 
                 0 
                 0 
               
               
                 NC + Low SOD 
                 500 
                 0 
               
               
                 NC + High SOD 
                 2500 
                 0 
               
               
                 NC + Low CAT 
                 0 
                 100 
               
               
                 NC + High CAT 
                 0 
                 500 
               
               
                 NC + Low SOD + Low CAT 
                 500 
                 100 
               
               
                 NC + Low SOD + High CAT 
                 500 
                 500 
               
               
                   
               
               
                 *PC: Avilamycin at 90.7 g/lb 
               
               
                 12 replicates per treatment with 4 piglets (2 barrows + 2 gilts) per replicate 
               
               
                 Weaning age 21 d 
               
            
           
         
       
     
     Replication/piglets per treatment: Treatments 1-8 fed to 12 replicates each of 4 piglets (2 barrows+2 gilts) per replicate. 
     
       
         
           
               
             
               
                 TABLE 8 
               
             
            
               
                   
               
               
                 Test measurements 
               
            
           
           
               
               
               
               
            
               
                 Data/Sample 
                   
                   
                   
               
               
                 Collected 
                 When 
                 Description 
                 Measurements 
               
               
                   
               
               
                 Growth 
                 Day 0, 21, 
                 Individual body weights 
                 FI, BW, BWG 
               
               
                 performance 
                 and 42 
                 (0, 21, and 42 days) and 
                 to calculate 
               
               
                   
                   
                 Feed Intake (Days 0-21 
                 adjusted FCR 
               
               
                   
                   
                 and 21-42) 
               
               
                   
               
            
           
         
       
     
     Piglet Source: Piglets (post-weaned, at 21 days of age, called Day 0) are collected in early am (day of placement or Day 0), weighed (2 barrows &amp; 2 gilts per pen), and assigned to each experimental pen. Each piglet is weighed individually and assigned to a pen, with very high and very low body weights excluded from the study. After all piglets are assigned to a pen, the body weights are checked to ensure no treatment is more than 1 standard deviation from another treatment. 
     The basal diet is shown in  FIG. 16 . 
     Experimental results on FCR (d 0-42) are shown in  FIG. 17 :
         There was significant difference observed in growth performance between positive and negative control.   Combining SOD &amp; CAT or feeding CAT and SOD alone gave similar performance to the antibiotic treatment and significantly better than NC.       

     Example 3: Efficacy of Antioxidant Enzymes (SOD and CAT) Supplemented at Different Doses Alone or in Combination on the Growth Performance of Early Weaned Piglet 
     Summary 
     The effect of antioxidant enzymes (SOD and CAT) alone at different doses and in combination on the growth performance of early weaned piglets was evaluated in a trial run. A total of eight treatments were tested during the study: 6 test groups: SOD (Product A, SEQ ID No. 1 at 1250 and 2500 U/kg), CAT (Product B, SEQ ID NO 7 and Product C, SEQ ID NO 250 at 100 U/kg) and 2 combinations (A 500 U/kg+B 100 U/kg; and A 500 U/kg+B 100 U/kg); were compared against a Positive Control feed (fed with Avilamycin at 90.7 g/lb) and a Negative Control (standard ration). Each of treatments contained 12 replicates per treatment randomly assigned and containing 5 male piglets per replicate for a total number of 480 animals on study. Piglets were randomly assigned to treatments on Trial Day 0 (post-weaning at 21 days of age). At 42 days of age, live performance (growth weight gain and feed conversion) was determined. All rations were formulated with an increase of approximately 5-6% additional crude protein above normal commercial levels. Blood samples were collected at day 0, 14 and 42 to evaluate oxidative stress parameters at DSM. Gut tissue samples at the duodenum and ileum to evaluate gene expression linked to oxidative stress, and intestinal content (ileum and caecum), to study the microbiome population, were collected from 12 animals at the beginning of the trial (baseline) and one animal per pen (12 piglets×8 treatments) at day 14 and at day 42. For the entire grow-out period (Days 0-42), body weight gain showed significant improvement over the Negative Control group when piglets were fed diets containing 2000 U/kg of SOD (Product A), 100 U/kg of CAT B, and both combination of 400 U/kg of SOD (Product A) with 100 U/kg of both CAT products B &amp; C, with the greatest improvements coming with the combination of 400 U/kg of SOD with 100 U/kg of CAT B, which also performed statistically similar to the Positive Control ration that contained Avilamycin at 90.7 g/lb. Feed conversion improved significantly between Positive Control and Negative Control. 
     Test System 
     The commercial-simulated test model employed in this study used piglets reared under a normal swine industry Starter diet (Trial Day 0-21) and Grower diet (Trial Day 21-42), reared on slatted floors. Ration formulations were conducted via computer-generated linear regression program that simulates formulations conducted during practical swine production techniques. Treatments were tested in male piglets. Piglets were continuously fed their experimental diets from time of placement on Trial Day 0 to Trial Day 42. 
     
       
         
           
               
             
               
                 TABLE 9 
               
             
            
               
                   
               
               
                 Treatments 
               
            
           
           
               
               
               
            
               
                 Treatment 
                   
                   
               
               
                 Number (T) 
                 Treatment Description 
                 Dose inclusion 
               
               
                   
               
               
                 1 
                 Neg. control 
                 — 
               
               
                 2 
                 PC: Avylamycin 
                 90.7 g/lb 
               
               
                 3 
                 NC + Product A 
                 A = 1000 U/kg 
               
               
                 4 
                 NC + Product A 
                 A = 2000 U/kg 
               
               
                 5 
                 NC + Product B 
                 B = 100 U/kg 
               
               
                 6 
                 NC + Product C 
                 C = 100 U/kg 
               
               
                 7 
                 NC + Product 
                 A = 400 U/kg 
               
               
                   
                 A + Product B 
                 B = 100 U/kg 
               
               
                 8 
                 NC + Product 
                 A = 400 U/kg 
               
               
                   
                 A + Product C 
                 C = 100 U/kg 
               
               
                   
               
            
           
         
       
     
     Piglets were weighed and randomly placed into each pen on Trial Day 0 and fed their respective diets. Each pen had sufficient floor density, feeder and waterer space for each grow-out area for the piglets. Following 42 days of grow-out, piglets were weighed, feed consumption determined, and feed conversion (feed consumed/body weight) calculated. 
     Materials and Methods 
     Experimental Design 
     A total of 500 male piglets (a sufficient number to ensure availability of at least 480 healthy male piglets for the conduct of the study) were obtained from a swine breeder on Trial Day 0 (upon weaning, when the piglets were 21 days of age). Piglets were fed their respective treatment feed ad libitum from Trial Day 0 to Trial Day 42. 
     Housing and Daily Observations 
     Each experimental test unit of swine pens was housed in separated pens, located in a room containing forced air heaters with a cross-house ventilation system. Piglets were placed in a 6 ft×6 ft pen floor area with a minimum of 9.0 ft 2  per piglet (without feeder and waterer space) provided. At least two nipple drinkers per pen (via well water) provided water. Piglets were observed daily for overall health, behavior and/or evidence of toxicity, and environmental conditions. Temperature in the test facility was checked daily. Drinking water and feed were confirmed to be provided ad libitum. No type of medication (other than test material) was administered during the entire feeding period. 
     Data and Observations 
     Live performance body weights and feed intakes were collected on Days 0, 14, 21, and 42 during the growing period. Weight gain, feed intake, feed:gain ratio (feed efficiency) were calculated for 0-42 days of age between weaning and Trial Day 42. Differences between piglets fed control and test groups were statistically evaluated at P&lt;0.05 in a typical ANOVA analysis of variance test model, employing Treatment×Replicate RCB (Randomized Complete Block). Control group was considered to be the following: Treatment 2, containing Avilamycin at 90.7 g/lb. 
     At the end of the study, all piglets were humanely euthanized and were disposed of according to local regulations via on-farm composting techniques. 
     Diet and Water Administration 
     Diets were fed in two feed phases: Starter diet (0-21 days of age) and Grower diet (21-42 days of age). All diets were offered ad libitum, without restriction. Fresh well water (from the research facility deep well) was provided ad libitum. 
     
       
         
           
               
             
               
                 TABLE 10 
               
             
            
               
                   
               
               
                 Feed Formulation Parameters 
               
            
           
           
               
               
               
               
            
               
                   
                   
                 Starter (PC) 
                 Grower (PC) 
               
               
                   
                 Nutrient 
                 0-21 days 
                 21-42 days 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Metabolizable Energy (kcal/kg) 
                 3150 
                 3200 
               
               
                   
                 Metabolizable Energy (kcal/#) 
                 1425 
                 1450 
               
               
                   
                 Protein (%) 
                 22.000 
                 20.000 
               
               
                   
                 Lysine (%) 
                 1.200 
                 1.052 
               
               
                   
                 Methionine + Cystine (%) 
                 0.800 
                 0.700 
               
               
                   
                 Total Phosphorus (%) Min 
                 0.941 
                 0.819 
               
               
                   
                 Available Phosphorus (%) 
                 0.650 
                 0.550 
               
               
                   
                 Total Calcium (%) 
                 0.750 
                 0.650 
               
               
                   
                 Dietary Sodium (%) 
                 0.200 
                 0.180 
               
               
                   
                 Dietary Choline (g/kg) 
                 1.305 
                 1.211 
               
               
                   
                   
               
            
           
         
       
     
     Results 
     For the entire grow-out period (Days 0-42), body weight gain ( FIG. 18 ) showed significant improvement over the Negative Control group (no added test materials) when piglets were fed diets containing 2000 U/kg of Product A, 100 U/kg of Product B, and a combination of 400 U/kg of Product A with 100 U/kg of both Product B and Product C, with the greatest improvements coming with the combination of 400 U/kg of Product A with 100 U/kg of Product B, which also performed statistically similar to the Positive Control ration that contained Avilamycin at 90.7 g/lb. As shown in  FIG. 19 , feed conversion improved between Treatment 2 (Positive Control) and Treatment 1 (Negative Control) over the period of d0-d42. In particular, inclusion of SOD+CAT (independently of the candidate B or C) in the ratio 400:100 U/kg showed significant improvement on FCR performance. 
     In conclusion, the use of a combination of 80 ml/MT of Product A and either 4 ml/MT or 20 ml/MT of Product B appeared to significantly improve 0-42 days of age body weight gains and feed conversion as compared to a standard control ration. Therefore, when commercial piglets are grown on concrete slat floors, this combination appears to have the great potential to result in better live performance. 
     Analysis and calculation of body weight coefficient of variation at day 14 shows a significant effect of the treatment according to the invention on CV of BW. The data is shown in table 11. The results show that the enzymes according to the invention improve flock uniformity compared to the control T1. 
     
       
         
           
               
             
               
                 TABLE 11 
               
             
            
               
                   
               
               
                 Body weight coefficient of variation at day 14 
               
            
           
           
               
               
            
               
                   
                 Treatment 
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 Criterion 
                 T1 
                 T2 
                 T3 
                 T4 
                 T5 
                 T6 
                 T7 
                 T8 
               
               
                   
               
               
                 Average Body Wt. (kg) Day 14 
                 8.998 
                 9.215 
                 9.133 
                 9.149 
                 9.111 
                 9.105 
                 9.182 
                 9.173 
               
               
                 Stat  1   
                 b 
                 a 
                 ab 
                 ab 
                 ab 
                 ab 
                 a 
                 a 
               
               
                 Feed Conversion Corrected Day 0-14 
                 1.232 
                 1.215 
                 1.223 
                 1.220 
                 1.223 
                 1.224 
                 1.218 
                 1.217 
               
               
                 Stat  1   
                 a 
                 a 
                 a 
                 a 
                 a 
                 a 
                 a 
                 a 
               
               
                 Mortality % Day 0-14 
                 1.667 
                 0.000 
                 0.000 
                 0.000 
                 0.000 
                 0.000 
                 1.667 
                 0.000 
               
               
                 Stat  1   
                 a 
                 a 
                 a 
                 a 
                 a 
                 a 
                 a 
                 a 
               
               
                 Average Body Wt. Gain (kg) Day 0-14 
                 3.503 
                 3.720 
                 3.562 
                 3.574 
                 3.596 
                 3.578 
                 3.710 
                 3.607 
               
               
                 Stat  1   
                 b 
                 a 
                 ab 
                 ab 
                 ab 
                 ab 
                 a 
                 ab 
               
               
                 Body Weight Coefficient of Variation (Day 14) 
                 6.023 
                 4.700 
                 4.552 
                 5.060 
                 5.474 
                 4.952 
                 5.516 
                 5.791 
               
               
                 Stat  1   
                 c 
                 ab 
                 a 
                 abc 
                 abc 
                 abc 
                 abc 
                 bc 
               
               
                 Feed Intake (kg/pig) Day 0-14 
                 4.36  
                 4.52  
                 4.36  
                 4.36  
                 4.40  
                 4.38  
                 4.57  
                 4.39  
               
               
                 Stat  1   
                 a 
                 a 
                 a 
                 a 
                 a 
                 a 
                 a 
                 a 
               
               
                   
               
               
                   1  Means within a row without a common superscript are significantly different (P &lt; 0.05) as determined by Least Significant Difference. 
               
            
           
         
       
     
     Example 4: Effect of Antioxidant Enzymes (SOD and CAT) Alone or in Combination on Plasmatic Antioxidant Enzymes, Oxidative Stress Index and Intestinal Gene Expression Response of Weaned Piglets (Based on Animal Trial of Example 3) 
     Summary 
     The objective of this study was to evaluate anti-oxidant enzymes supplementation (SOD and CAT) alone and in combination in early weaned piglets, and if these enzymes can potentially alleviate the oxidative stress impact on weaned piglets and consequently improve the growth performance. In the in vivo trial (example 3), plasma samples were collected at day 0 (baseline, weaning moment), day 14 and day 42 of the study for additional analysis. 
     Piglets supplemented with CAT alone showed a significant increase in the plasmatic antioxidant activity (PAT). At day 42, also piglets supplemented with CAT showed a significant increase of GPx activity. Gene expression showed significant modulation at day 14. In duodenum at day 14, the supplementation of antioxidant enzymes (SOD+CAT) showed a downregulation of the genes that encode NQO1 (protecting the cells against Oxidative Stress OS) and the anti-oxidant enzyme GSTP1 (p=0.07 and p=0.005 respectively) suggesting that diet supplementation with a combination of SOD and CAT decreases stress protein expressions at the beginning of small intestine of weaned piglets. SCARA3 showed also a significant increase in the same group (p=0.003), avoiding accumulation of ROS. At the duodenum, the gene that encodes the antioxidant enzyme GPX1 showed a significant upregulation in piglets supplemented with CAT alone compared to control group and those results are in agreement with the GPx plasmatic activity found. And at the ileum level, supplementation of CAT and SOD alone showed a upregulation on the protecting protein NQO1 but a downregulation on HSP70, and piglets supplemented with SOD+CAT showed a downregulation on the genes NOX5, oxidative stress marker, and CAT, antioxidant enzyme. Those data provide evidence that diet supplementation with a SOD, CAT and the combination of both enzymes, potentially decrease oxidative stress status in weaned piglets. 
     
       
         
           
               
             
               
                 TABLE 12 
               
             
            
               
                   
               
               
                 Test System 
               
            
           
           
               
               
               
            
               
                 Treatment 
                   
                   
               
               
                 Number (T) 
                 Treatment Description 
                 Dose inclusion 
               
               
                   
               
               
                 1 
                 Neg. control 
                 — 
               
               
                 2 
                 PC: Avylamycin 
                 90.7 g/lb 
               
               
                 3 
                 NC + Product A 
                 A = 1000 U/kg 
               
               
                 4 
                 NC + Product A 
                 A = 2000 U/kg 
               
               
                 5 
                 NC + Product B 
                 B = 100 U/kg 
               
               
                 6 
                 NC + Product C 
                 C = 100 U/kg 
               
               
                 7 
                 NC + Product 
                 A = 400 U/kg 
               
               
                   
                 A + Product B 
                 B = 100 U/kg 
               
               
                 8 
                 NC + Product 
                 A = 400 U/kg 
               
               
                   
                 A + Product C 
                 C = 100 U/kg 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 13 
               
             
            
               
                   
               
               
                 Biological samples and analysis 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Enzymes 
                   
                   
               
               
                 Type of 
                   
                   
                 activity: SOD, 
                 Vitamins 
                 Gene 
               
               
                 sample* 
                 Treat. 
                 Nb sample/treat. 
                 CAT GPX, OSI 
                 A &amp; E 
                 expression 
               
               
                   
               
               
                 Plasma d 0 
                 0 
                 12 
                 X 
                   
                   
               
               
                   
                 0 
                 12 
                   
                 X 
               
               
                 Plasma d 14 
                 1, 4, 6, 8 
                 12 × 4 = 48 
                 X 
               
               
                   
                 1, 4, 6, 8 
                 12 × 4 = 48 
                   
                 X 
               
               
                 Plasma d 42 
                 1, 4, 6, 8 
                 12 × 4 = 48 
                 X 
               
               
                   
                 1, 4, 6, 8 
                 12 × 4 = 48 
                   
                 X 
               
               
                 Duodenum 
                 1, 4, 6, 8 
                 12 samples x4 
                   
                   
                 x 
               
               
                 and Ileumd 0 
                   
                 treatments x 2 
               
               
                   
                   
                 tissues = 96 
               
               
                 Duodenum 
                 1, 4, 6, 8 
                 12 samples x4 
                   
                   
                 x 
               
               
                 and Ileum 
                   
                 treatments x 2 
               
               
                 d 14 
                   
                 tissues = 96 
               
               
                 Duodenum 
                 1, 4, 6, 8 
                 12 samples x4 
                   
                   
                 x 
               
               
                 and Ileum 
                   
                 treatments x 2 
               
               
                 d 42 
                   
                 tissues = 96 
               
               
                   
               
            
           
         
       
     
     Methods 
     Oxidative Stress PCR Array 
     Duodenum and ileum were collected for gene expression measurement of genes related to oxidative stress, at day 0 and day 14. The list of the genes evaluated is presented in the table 14 below. 
     
       
         
           
               
             
               
                 TABLE 14 
               
             
            
               
                   
               
               
                 Genes related to OS 
               
            
           
           
               
               
               
            
               
                 Gene 
                   
                   
               
               
                 Symbol 
                 Official Full Name 
                 Function 
               
               
                   
               
               
                 NQO1 
                 NAD(P)H dehydrogenase, 
                 Protection against OS 
               
               
                   
                 quinone 1 
               
               
                 TXN 
                 Thioredoxin 
                 Anti-oxidant enzymes 
               
               
                 NOX5 
                 NADPH oxidase, EF-hand 
                 Oxidative stress marker 
               
               
                   
                 calcium binding domain 5 
               
               
                 HSP70 
                 Heat shock protein 70 
                 Protection against OS 
               
               
                 GPX1 
                 Glutathione peroxidase 1 
                 Anti-oxidant enzymes 
               
               
                 SCARA3 
                 Scavenger receptor class 
                 Protection against OS 
               
               
                   
                 A, member 3 
               
               
                 GPX3 
                 Glutathione peroxidase 3 
                 Anti-oxidant enzymes 
               
               
                 GSTP1 
                 Glutathione S-transferase P 
                 Anti-oxidant enzymes 
               
               
                 SOD3 
                 Superoxide dismutase 3, 
                 Anti-oxidant enzymes 
               
               
                   
                 extracellular 
               
               
                 CAT 
                 Catalase 
                 Anti-oxidant enzymes 
               
               
                 PRDX5 
                 Peroxiredoxin 5 
                 Anti-oxidant enzymes 
               
               
                   
               
            
           
         
       
     
     Total RNA was extracted from tissues (stored at −20° C. in RNA later) by lysing tissue with FastPrep® 24 (MP Biomedicals, Illkirch, France), using the phenol-chloroform method (TRIzol reagent; Invitrogen, Invitrogen, Cergy Pontoise, France) followed by purification using RNeasy columns by automated method with the Qiacube HT (Qiagen, Courtaboeuf, France). The concentration of RNA was measured by NanoDrop ND-1000 Spectrophotometer (Thermo Fisher Scientific, Illkirch, France) and the purity was estimated by A260/A280 ratio. RNA integrity was assessed by using the Agilent 2100 Bioanalyzer (Agilent Technologies, Basel, Switzerland). The threshold of the RNA Integrity Number (RIN) was set at 7.5 to validate sufficient quality of the RNAs. 
     The reverse transcription was performed using RT 2  First Strand Kit (Qiagen, Courtaboeuf, France) with 500 ng of total RNA. The reaction mix was incubated 5 minutes at 42° C. for genomic DNA elimination, followed by the reverse transcription 15 minutes at 42° C. The inactivation of the enzyme was performed by heating 5 minutes at 95° C. The resultant cDNAs were amplified with RT 2  SYBR Green Mastermixes (Qiagen, Courtaboeuf, France) for real-time PCR. The expression of target genes was normalized with housekeeping genes listed in the table below: 
     
       
         
           
               
               
               
             
               
                   
                   
               
               
                   
                 Gene Symbol 
                 Official Full Name 
               
               
                   
                   
               
             
            
               
                   
                 UBC 
                 ubiquitin C 
               
               
                   
                 GAPDH 
                 glyceraldehyde-3-phosphate dehydrogenase 
               
               
                   
                   
               
               
                   
                 The thermal cycling was run on Light Cycler 96 (Roche Diagnostics, Meylan, France) with the following program: 95° C. 10 min, followed by 40 cycles of denaturation at 95° C. 15 seconds and hybridization/elongation at 60° C. 1 min. The Delta Ct method was used to determine expression of target genes (Livak and Schmittgen, 2001) 
               
            
           
         
       
     
     Oxidative Stress Index: FRAS5 
     An oxidative stress index was calculated as the ratio of reactive oxygen metabolites (ROM) and Plasma antioxidant capability (PAT) determined in plasma and liver lysate samples. ROM and 
     PAT were analyzed using commercially methods (d-ROM fast test and PAT test) on FRAS5 instrument (Innovatics Laboratory, Philadelphia, USA). For d-ROM test, 10 μL of sample was mixed with an acidic buffer. Then, a chromogen was added, and measured photometrically at 505 nm. The results are expressed in UCarr (1 UCarr=0.08 mg of H2O2/dl). For PAT test, 10 μl of sample was added in a colored solution (mix of source ferric ions and chromogen). The intensity of chromatic change was measured at 505 nm. The results are expressed in UCor (1 UCor=1.4 μM of Vitamin C equivalent). The oxidative stress index was calculated as the ratio of d-ROMs test value to PAT test value. 
     Total Proteins Determination 
     The concentration of total proteins was determined in liver lysate and plasma, using the Pierce™ BCA Protein Assay Kit (Thermo Fisher Scientific, Illkirch-Graffenstaden, France). The samples were processed following the supplier&#39;s recommendations. Plasma samples were diluted 100 times. 25 μL of standards or samples were added to 200 μL of working reagent and incubated 30 minutes at 37° C. The colorimetric intensity was measured at 562 nm. Results are expressed in μg of total protein per mL of sample. 
     Plasma CAT Activity 
     The activity of the catalase was determined using the Amplex® Red Catalase Assay Kit (Molecular Probes A22180). Briefly 25 μL of standards, plasma (adjusted at 1 μg of protein/well) was mixed with 25 μL of 40 μM H 2 O 2  solution and incubated for 30 minutes at room temperature. 50 μL of the Amplex Red/HRP working solution was added to each microplate well containing the samples and standards and incubated 30 min at 37° C. protected from light. The absorbance was measured at 560 nm, and the concentration of CAT in the samples was calculated based on the standard curve. 
     Plasma SOD Activity 
     The activity of the superoxide dismutase was determined using the SOD determination KIT (Sigma 19160) and quantity if reagent in each well is described in table 15 below: 
     
       
         
           
               
               
               
               
               
               
             
               
                   
                 TABLE 15 
               
               
                   
                   
               
               
                   
                 SOD 
                   
                   
                   
                   
               
               
                   
                 standard 
                 Samples 
                 Blank1 
                 Blank2* 
                 Blank 3 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 SOD Standard 
                 20 μl 
                 — 
                 — 
                 — 
                 — 
               
               
                 Sample solution 
                 — 
                 20 μl 
                 — 
                 20 μl 
                 — 
               
               
                 ddH 2 O 
                   
                   
                 20 μl 
                   
                 20 μl 
               
               
                 WST working solution 
                 200 μl  
                 200 μl  
                 200 μl  
                 200 μl  
                 200 μl  
               
               
                 Enzyme working 
                 20 μl 
                 20 μl 
                 20 μl 
               
               
                 solution 
               
               
                 Dilution buffer 
                 — 
                 — 
                 — 
                 20 μl 
                 20 μl 
               
               
                   
               
            
           
         
       
     
     Plasma samples were adjusted to bring 60014 of total protein in the reaction. The plates were incubated for 20 min at 37° C., and the absorbance was read at 450 nm. The SOD activity (SODA) was measured as follow and calculated using the standard curve: 
       SODA={[(A blank 1−A blank 3)−(A sample−A blank 2)]/(A blank−1A blank 3)}*100
 
     Plasma GPx Activity 
     The activity of the Glutathione peroxidase was determined using the GPx determination KIT (abcamab102530). Briefly, 40 μL of the colorimetric reaction mix was added to 100 μL of standards and 10 μL of cumene hydroperoxide was added to the standards and to the 50 μL of samples (Plasma samples were adjusted to bring 600 μg of total protein in the reaction). The absorbance at 340 nm was measured (A1), and after 5 min at 25° C., a second measurement was done (A2). 
     The GPx activity was calculated as follow: 
     
       
         
           
             
               1 
               ⁢ 
               
                 ) 
               
               ⁢ 
               
                   
               
               ⁢ 
               
                 Δ 
                 ⁢ 
                 A 
                 ⁢ 
                 _ 
               
               ⁢ 
               340 
               ⁢ 
               
                   
               
               ⁢ 
               nm 
             
             = 
             
               ( 
               
                 
                   ( 
                   
                     
                       Sample 
                       ⁢ 
                       
                           
                       
                       ⁢ 
                       A 
                       ⁢ 
                       
                           
                       
                       ⁢ 
                       1 
                     
                     - 
                     
                       Sample 
                       ⁢ 
                       
                           
                       
                       ⁢ 
                       A 
                       ⁢ 
                       
                           
                       
                       ⁢ 
                       2 
                     
                   
                   ) 
                 
                 - 
                 
                   
 
                 
                 ⁢ 
                 
                     
                 
                 ⁢ 
                 
                   ( 
                   
                     
                       Reagent 
                       ⁢ 
                       
                           
                       
                       ⁢ 
                       control 
                       ⁢ 
                       
                           
                       
                       ⁢ 
                       A 
                       ⁢ 
                       
                           
                       
                       ⁢ 
                       1 
                     
                     - 
                     
                       Reagent 
                       ⁢ 
                       
                           
                       
                       ⁢ 
                       control 
                       ⁢ 
                       
                           
                       
                       ⁢ 
                       A 
                       ⁢ 
                       
                           
                       
                       ⁢ 
                       2 
                     
                   
                   ) 
                 
               
               ) 
             
           
         
       
       
         
           
             
               2 
               ⁢ 
               
                 ) 
               
               ⁢ 
               
                   
               
               ⁢ 
               B 
             
             = 
             
               
                 ( 
                 
                   
                     Δ 
                     ⁢ 
                     
                         
                     
                     ⁢ 
                     
                       A 
                       ⁢ 
                       _ 
                     
                     ⁢ 
                     340 
                     ⁢ 
                     
                         
                     
                     ⁢ 
                     nm 
                   
                   - 
                   intercept 
                 
               
               
                 Slope 
                 ) 
               
             
           
         
       
       
         
           
             
               
                 3 
                 ⁢ 
                 
                   ) 
                 
                 ⁢ 
                 
                     
                 
                 ⁢ 
                 GPx 
                 ⁢ 
                 
                     
                 
                 ⁢ 
                 Activity 
               
               = 
               
                 
                   
                     ( 
                     B 
                     ) 
                   
                   
                     
                       
                         ( 
                         
                           
                             T 
                             ⁢ 
                             
                                 
                             
                             ⁢ 
                             2 
                           
                           - 
                           
                             T 
                             ⁢ 
                             
                                 
                             
                             ⁢ 
                             1 
                           
                         
                         ) 
                       
                       * 
                       V 
                     
                     ) 
                   
                 
                 * 
                 D 
               
             
             ⁢ 
             
                 
             
           
         
       
     
     Where: 
     B=NADPH amount that was decreased between T1 and T2 (in nmol). 
     T1=Time of the first reading (A1) (minutes). 
     T2=Time of second reading (A2) (minutes). 
     V=Pretreated sample volume added into the reaction well (mL). 
     D=Sample dilution factor. 
     Statistical Analysis 
     ANOVA was performed for plasmatic parameters and student test was calculated to evaluate the significance of the differences observed in gene expression. 
     Results 
     Plasmatic Parameters 
     Results of the plasmatic parameters (SOD, CAT and GPx, OS) at day 0, 14 and 42 can be summarized as follows:
         At day 14, the plasmatic activity of the antioxidant enzymes SOD, CAT and GPx were higher than at day 0.   For the GPx activity, at day 42, the addition of the enzymes in the diet showed a significant increase in group receiving either the CAT alone or in combination with the SOD.   At day 0, the reactive oxygen metabolites (d-ROM) and the 051 were higher than at day 14 and 42, reflecting the level of response to the stress generated in the early weaning period of the animals, and indicating a higher sensitivity of this biomarker in acute stress compared to the activity of SOD and CAT.   Interestingly, the d-ROM showed an increase in animals supplemented with CAT or CAT+SOD in both time point.   At day 14, the plasmatic antioxidant capacity showed a significant difference between experimental groups (p&lt;0.0001) with an increase in group supplemented with CAT or SOD+CAT.       

     Gene Expression Targeting Oxidative Stress 
     Results of the gene expression analysis are shown in Table 16 (Gene expression fold change of oxidative stress related genes in duodenum at day 14), Table 17 (Gene expression fold change of oxidative stress related genes in ileum at day 42) and can be summarized as follows:
         In the group supplemented with both enzymes (SOD+CAT), a downregulation of the genes that encode NQO1 (protecting the cells against OS) and the anti-oxidant enzyme GSTP1 (p=0.07 and p=0.005 respectively) was observed suggesting that diet supplementation with a combination of SOD and CAT decreases stress protein expressions at the beginning of small intestine of weaned piglets.   SCARA3 showed also a significant increase in the same group (p=0.003), avoiding accumulation of ROS.   In duodenum at day 42, only the gene that encode the antioxidant enzyme GPX1 gene showed a significant upregulation (p=0.019) in piglets supplemented with CAT alone compared to control group with a fold change of 1.34. Those results are in line with the GPx plasmatic activity found in the piglets after 42 days of supplementation.   Piglets supplemented with SOD alone showed a upregulation on the protecting protein a NQO1   Similarly to SOD supplementation alone, piglets supplemented with CAT alone showed an upregulation of NQO1. Besides that, piglets showed a upregulation on antioxidant enzyme GSTP1 and a downregulation of a redox marker NOX5.   Finally, piglets supplemented with SOD+CAT showed a downregulation on the genes NOX5, oxidative stress marker, and CAT, antioxidant enzyme.       

     
       
         
           
               
             
               
                 TABLE 16 
               
             
            
               
                   
               
               
                 Gene expression fold change of oxidative 
               
               
                 stress related genes in duodenum 
               
            
           
           
               
               
            
               
                   
                 Treatments 
               
            
           
           
               
               
               
               
               
            
               
                   
                 NC 
                 NC + SOD 
                 NC + CAT 
                 NC + SOD + CAT 
               
               
                 Gene # 
                 A 
                 D 
                 F 
                 H 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Nqo1 
                 1 
                 −1.25  
                 — 
                 −1.55 
               
               
                 TXN 
                 1 
                 −1.27  
                 — 
                 −1.23 
               
               
                 NoX5 
                 1 
                 1.26 
                 — 
                  1.25 
               
               
                 HSP70 
                 1 
                 1.27 
                 — 
                 −1.33 
               
               
                 GPX1 
                 1 
                 −1.08  
                 — 
                 −1.11 
               
               
                 SCARA3 
                 1 
                 1.18 
                 — 
                     1.53 ** 
               
               
                 GPX3 
                 1 
                 1.12 
                 — 
                 −1.18 
               
               
                 GSTP1 
                 1 
                 −1.18  
                 — 
                   −1.60 ** 
               
               
                 SOD3 
                 1 
                 1.17 
                 — 
                      1.37 * 
               
               
                 CAT 
                 1 
                 −1.05  
                 — 
                     −1.45 * 
               
               
                 PRDX5 
                 1 
                  −1.22 * 
                 — 
                   −1.42 ** 
               
               
                   
               
               
                 * p &lt; 0.05; 
               
               
                 ** p &lt; 0.01 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 17 
               
             
            
               
                   
               
               
                 Gene expression fold change of oxidative 
               
               
                 stress related genes in ileum. 
               
            
           
           
               
               
               
               
               
            
               
                   
                 NC 
                 NC + SOD 
                 NC + CAT 
                 NC + SOD + CAT 
               
               
                 Gene # 
                 A 
                 D 
                 F 
                 H 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Nqo1 
                 1 
                 2.00 
                 1.68 
                 1.40 
               
               
                 TXN 
                 1 
                 1.23 
                 1.48 
                 −1.13 
               
               
                 NoX5 
                 1 
                 −1.05 
                 −1.65 
                 −1.64 
               
               
                 HSP70 
                 1 
                 −1.57 
                 −1.74 
                 −1.33 
               
               
                 GPX1 
                 1 
                 −1.40 
                 1.31 
                 −1.24 
               
               
                 SCARA3 
                 1 
                 1.40 
                 −1.26 
                 −1.16 
               
               
                 GPX3 
                 1 
                 1.20 
                 1.29 
                 −1.24 
               
               
                 GSTP1 
                 1 
                 −1.02 
                 1.56 
                 1.11 
               
               
                 SOD3 
                 1 
                 1.25 
                 1.11 
                 1.05 
               
               
                 CAT 
                 1 
                 −1.01 
                 −1.20 
                 −1.64 
               
               
                 PRDX5 
                 1 
                 1.05 
                 1.40 
                 −1.10 
               
               
                   
               
            
           
         
       
     
     CONCLUSION 
     Plasmatic antioxidant enzymes, specially SOD and CAT, showed a clear increase at day 14, independently of the treatment, indicating that the oxidative stress situation induced by piglet weaning is progressively corrected during the postweaning period. A significant increase in the plasmatic antioxidant activity in piglets supplements with CAT alone could be observed. At day 42, piglets supplemented with CAT showed a significant increase of GPx activity. 
     Gene expression showed significant modulation at day 14 and not at day 42. In duodenum at day 14, the supplementation of antioxidant enzymes (SOD+CAT) showed a downregulation of the genes that encode NQO1 (protecting the cells against OS) and the anti-oxidant enzyme GSTP1 (p=0.07 and p=0.005 respectively) suggesting that diet supplementation with a combination of SOD and CAT decreases stress protein expressions at the beginning of small intestine of weaned piglets. SCARA3 showed also a significant increase in the same group (p=0.003), avoiding accumulation of ROS. 
     At the duodenum, only the gene that encode the antioxidant enzyme GPX1 showed a significant upregulation in piglets supplemented with CAT alone compared to control group and those results are in agreement with the GPx plasmatic activity found at 42 days. And at the ileum level, supplementation of CAT and SOD alone showed a upregulation on the protecting protein NQO1 and piglets supplemented with SOD+CAT showed a downregulation on the genes NOX5, oxidative stress marker, and CAT, antioxidant enzyme. Those data provide evidence that diet supplementation with a SOD, CAT and the combination of both enzymes, potentially decrease oxidative stress status in weaned piglets. 
     Example 5 Cloning and Expression of Superoxide Dismutase from  Trichoderma reesei    
     Strains 
       Escherichia coli  Top-10 strain purchased from Invitrogen (Life Technologies, Carlsbad, Calif., USA) was used to propagate our expression vectors encoding for lysozyme polypeptides.  Aspergillus oryzae  strain MT3568 was used for heterologous expression of the lysozyme polypeptide encoding sequences.  A. oryzae  MT3568 is an amdS (acetamidase) disrupted gene derivative of  Aspergillus oryzae  JaL355 (WO 2002/40694) in which pyrG auxotrophy was restored by disrupting the  A. oryzae  acetamidase (amdS) gene with the pyrG gene. 
     Media 
     DAP2C-1 medium was composed of 0.5 g yeast extract, 30 g Maltodextrin, 11 g magnesium sulphate heptahydrate, 1 g dipotassium phosphate, 2 g citric acid monohydrate, 5.2 g potassium phosphate tribasic monohydrate, 1 mL Dowfax 63N10 (antifoaming agent), 2.5 g calcium carbonate, supplemented with 1 mL KU6 metal solution, and deionised water to 1000 mL. 
     KU6 metal solution was composed of 6.8 g ZnCl 2 , 2.5 g CuSO 4 .5H 2 O, 0.13 g NiCl 2 , 13.9 g FeSO 4 .7H 2 O, 8.45 g MnSO 4 .H 2 O, 3 g C 6 H 8 O 7 .H 2 O, and deionised water to 1000 mL. YP 2% glucose medium was composed of 10 g yeast extract, 20 g Bacto-peptone, 20 g glucose, and deionised water to 1000 mL. 
     LB plates were composed of 10 g of Bacto-tryptone, 5 g of yeast extract, 10 g of sodium chloride, 15 g of Bacto-agar, and deionised water to 1000 mL. 
     LB medium was composed of 10 g of Bacto-tryptone, 5 g of yeast extract, and 10 g of sodium chloride, and deionised water to 1000 mL. 
     COVE-Sucrose-T plates were composed of 342 g of sucrose, 20 g of agar powder, 20 mL of COVE salt solution, and deionised water to 1000 mL. The medium was sterilized by autoclaving at 15 psi for 15 minutes (Bacteriological Analytical Manual, 8th Edition, Revision A, 1998). The medium was cooled to 60° C. and 10 mM acetamide, Triton X-100 (50 μL/500 mL) were added. COVE-N-Agar tubes were composed of 218 g Sorbitol, 10 g Dextrose, 2.02 g KNO 3 , 25 g agar, 50 mL Cove salt solution, and deionised water up to 1000 mL. 
     COVE salt solution was composed of 2 6 g of MgSO 4 .7H 2 O, 26 g of KCl, 26 g of KH 2 PO 4 , 50 mL of COVE trace metal solution, and deionised water to 1000 mL. 
     COVE trace metal solution was composed of 0.04 g of Na 2 B 4 O 7 .10H 2 O, 0.4 g of CuSO 4 .5H 2 O, 1.2 g of FeSO 4 .7H 2 O, 0.7 g of MnSO 4 .H 2 O, 0.8 g of Na 2 MoO 4 .2H 2 O, 10 g of ZnSO 4 .7H 2 O, and deionised water to 1000 mL. 
     Cloning 
       Aspergillus niger  MBin118 is disclosed in WO 2004/090155. 
     The SEQ ID NO 1 polypeptide coding sequence was cloned from  Trichoderma reesei  QM6a DNA by PCR. 
       Trichoderma reesei  QM6a was cultivated in 100 ml of YP+2% glucose medium in 1000 ml Erlenmeyer shake flasks for 5 days at 20° C. Mycelia were harvested from the flasks by filtration of the medium through a Buchner vacuum funnel lined with MIRACLOTH® (EMD Millipore, Billerica, Mass., USA). Mycelia were frozen in liquid nitrogen and stored at −80C until further use. Genomic DNA was isolated using a DNEASY® Plant Maxi Kit (QIAGEN GMBH, Hilden Germany) according to the manufacturer&#39;s instructions. 
     Genomic sequence information was generated by Illumina MySeq (Illumina Inc., San Diego, Calif.). 5 rigs of the isolated  Trichoderma reesei  QM6a genomic DNA was used for library preparation and analysis according to the manufacturer&#39;s instructions. A 300 bp, paired end strategy was employed with a library insert size of 200-500 bp. The reads were subsequently fractionated to 25% followed by trimming (extracting longest sub-sequences having Phred-scores of 10 or more). These reads were assembled using ldba version 0.18. Contigs shorter than 200 bp were discarded. Genes were called using GeneMark.hmm ES version 2.3c and identification of the catalytic domain was made using “SOD_Cu” Hidden Markov Model provided by Pfam. A Swissprot entry of the identical sequence is also available: GORPL7 HYPJQ. The polypeptide coding sequence for the entire coding region was cloned from  Trichoderma reesei  QM6a genomic DNA by PCR using the primers (SEQ ID NO: A and SEQ ID NO: B) described below. 
     
       
         
           
               
            
               
                 (SEQ ID NO: A) 
               
               
                 5′-ACACAACTGGGGATCCACCATGCGGCCGTCTGGGTTCCT-3′ 
               
               
                   
               
               
                 (SEQ ID NO: B) 
               
               
                 5′-CTAGATCTCGAGAAGCTTTCACAGGGAGAAGAAGATGGC-3′ 
               
            
           
         
       
     
     Bold letters represent  Trichoderma harzianum  enzyme coding sequence. Restriction sites are underlined. The sequence to the left of the restriction sites is homologous to the insertion sites of pDau109 (WO 2005/042735). 
     In-Fusion™ Advantage PCR Cloning Kit Cat. nr 639620 
     The amplification reaction (50 μl) was performed according to the manufacturer&#39;s instructions (Thermo Scientific) with the following final concentrations: 
     1× Phusion HC buffer
 
200 uM dNTP
 
     2.0 mM MgCl 2    
     0.5 uM of each primer of SEQ ID NO: A+B
 
10 ng of  Trichoderma harzianum O 4 genomic DNA.
 
     The PCR reaction was incubated in a DYAD® Dual-Block Thermal Cycler (BioRad, USA) programmed for 1 cycle at 98° C. for 2 minutes; 30 cycles each at 98° C. for 10 seconds and 72° C. for two minutes followed by 1 cycle at 72° C. for 6 minutes. Samples were cooled to 10° C. before removal and further processing. 
     Five μl of the PCR reaction were analyzed by 1% agarose gel electrophoresis using 40 mM Tris base, 20 mM sodium acetate, 1 mM disodium EDTA (TAE) buffer. A major band of about 1 kb was observed. The remaining PCR reaction was purified directly with an ILLUSTRA™ GFX™ PCR DNA and Gel Band Purification Kit (GE Healthcare, Piscataway, N.J., USA) according to the manufacturer&#39;s instructions. 
     Two μg of plasmid pDau109 was digested with Bam HI and Hind III and the digested plasmid was run on a 1% agarose gel using 50 mM Tris base-50 mM boric acid-1 mM disodium EDTA (TBE) buffer in order to remove the stuffer fragment from the restricted plasmid. The bands were visualized by the addition of SYBR® Safe DNA gel stain (Life Technologies Corporation, Grand Island, N.Y., USA) and use of a 470 nm wavelength transilluminator. The band corresponding to the restricted plasmid was excised and purified using an ILLUSTRA™ GFX™ PCR DNA and Gel Band Purification Kit. The plasmid was eluted into 10 mM Tris pH 8.0 and its concentration adjusted to 20 ng per μl. An IN-FUSION® PCR Cloning Kit (Clontech Laboratories, Inc., Mountain View, Calif., USA) was used to clone the 1450 bp PCR fragment into pDau109 digested with Bam HI and Hind III (20 ng). The IN-FUSION® total reaction volume was 10 μl. The IN-FUSION® total reaction volume was 10 μl. The IN-FUSION® reaction was transformed into FUSION-BLUE™  E. coli  cells (Clontech Laboratories, Inc., Mountain View, Calif., USA) according to the manufacturer&#39;s protocol and plated onto LB agar plates supplemented with 50 μg of ampicillin per ml. After incubation overnight at 37° C., transformant colonies were observed growing under selection on the LB plates supplemented with 50 μg of ampicillin per mL. 
     Several colonies were selected for analysis by colony PCR using the pDau222 pDau109 vector primers described below. Four colonies were transferred from the LB plates supplemented with 50 μg of ampicillin per ml with a yellow inoculation pin (Nunc A/S, Denmark) to new LB plates supplemented with 50 μg of ampicillin per ml and incubated overnight at 37° C. 
     
       
         
           
               
               
            
               
                   
                 (SEQ ID NO: C) 
               
               
                   
                 Primer 8653: 5′-GCAAGGGATGCCATGCTTGG-3′ 
               
               
                   
                   
               
               
                   
                 (SEQ ID NO: D) 
               
               
                   
                 Primer 8654: 5′-CATATAACCAATTGCCCTC-3′ 
               
            
           
         
       
     
     Each of the three colonies were transferred directly into 200 μl PCR tubes composed of 5 μl of 2× Thermo Scientific Dream Tag™ PCR Master Mix (Thermo Fisher Scientific, Rockford, Ill., USA), 0.5 μl of primer 8653 (10 pm/μl), 0.5 μl of primer 8654 (10 pm/μl), and 4 μl of deionized water. Each colony PCR was incubated in a DYAD® Dual-Block Thermal Cycler programmed for 1 cycle at 94° C. for 60 seconds; 30 cycles each at 95° C. for 30 seconds, 60° C. for 45 seconds, 72° C. for 60 seconds, 68° C. for 10 minutes, and 10° C. for 10 minutes. 
     Four μl of each completed PCR reaction were submitted to 1% agarose gel electrophoresis using TAE buffer. All four  E. coli  transformants showed a PCR band of about 1 kb. Plasmid DNA was isolated from each of the four colonies using a QIAprep Spin Miniprep Kit (QIAGEN GMBH, Hilden Germany). The resulting plasmid DNA was sequenced with primers 8653 and 8654 using an Applied Biosystems Model 3730 Automated DNA Sequencer using version 3.1 BIG-DYE™ terminator chemistry (Applied Biosystems, Inc., Foster City, Calif., USA). 
     One plasmid was chosen for transforming  Aspergillus oryzae  MT3568.  A. oryzae  MT3568 is an amdS (acetamidase) disrupted gene derivative of  Aspergillus oryzae  JaL355 (WO 2002/40694) in which pyrG auxotrophy was restored by inactivating the  A. oryzae  amdS gene. Protoplasts of  A. oryzae  MT3568 were prepared according to the method described in European Patent, EP0238023, pages 14-15. 
       E. coli  190 containing the selected plasmid was grown overnight according to the manufacturer&#39;s instructions (Genomed) and the plasmid DNA was isolated using a Plasmid Midi Kit (Genomed JETquick kit, cat.nr. 400250, GENOMED GmbH, Germany) according to the manufacturer&#39;s instructions. The purified plasmid DNA was transformed into  Aspergillus oryzae  MT3568.  A. oryzae  MT3568 protoplasts were prepared according to the method of Christensen et al., 1988, Bio/Technology 6: 1419-1422. The selection plates consisted of COVE sucrose with +10 mM acetamide+15 mM CsCl+TRITON® X-100 (50 μl/500 ml). The plates were incubated at 37° C. Briefly, 8 uls of plasmid DNA representing 3 ugs of DNA was added to 100 uls MT3568 protoplasts. 250 ul of 60% PEG solution was added and the tubes were gently mixed and incubate at 37° for 30 minutes. The mix was added to 10 ml of pre-melted Cove top agarose (The top agarose melted and then the temperature equilibrated to 40 C in a warm water bath before being added to the protoplast mixture). The combined mixture was then plated on two Cove-sucrose selection petri plates with 10 mM acetamide. The plates are incubated at 37° C. for 4 days. Single  Aspergillus  transformed colonies were identified by growth on the selection Acetimide as a carbon source. Each of the four  A. oryzae  transformants were inoculated into 750 μl of YP medium supplemented with 2% glucose and also 750 μl of 2% maltodextrin and also DAP4C in 96 well deep plates and incubated at 37° C. stationary for 4 days. At same time the four transformants were restreaked on COVE-2 sucrose agar medium. 
     Culture broth from the  Aspergillus oryzae  transformants were then analyzed for production of the SEQ ID NO 1 polypeptide by SDS-PAGE using NUPAGE® 10% Bis-Tris SDS gels (Invitrogen, Carlsbad, Calif., USA) according to the manufacturer. Two bands at approximately 97 kDa and 45 kDa were observed for each of the  Aspergillus oryzae  transformants. One  A. oryzae  transformant producing the SEQ ID NO 1 polypeptide was selected and was cultivated in 1000 ml Erlenmeyer shake flasks containing 100 ml of DAP2C medium at 30° C. for 3 days with agitation at 150 rpm. 
     Using  Aspergillus versicolor, Aspergillus deflectus , or  Aspergillus egyptiacus , SEQ ID NO 2, 3, and 4 were similarly cloned and expressed. 
     Example 6 Cloning and Expression of Fungal Superoxide Dismutase 
     Strains 
       Escherichia coli  Top-10 strain purchased from TIANGEN (TIANGEN Biotech Co. Ltd., Beijing, China) was used to propagate our expression vector. 
       Aspergillus oryzae  strain MT3568 (described in WO2015040159) was used for heterologous expression of the genes described in Table 1. 
       Aspergillus oryzae  strain DAU785 (described in WO2018/113745) was used for heterologous expression of the genes described in the Table 2. 
     Media Dap4C medium was composed of 11 g MgSO 4 .7H 2 O, 1 g KH 2 PO 4 , 2.2 g Citric acid.H 2 O, 20 g glucose, 10 g maltose, 5.2 g K 3 PO 4 H 2 O, 0.5 g yeast extract, 1.25 g CaCO 3 , 0.5 ml AMG Trace element solution and deionized water to 1 liter. After autoclave, 3.3 ml of 20% Lactic Acid (autoclaved) and 9.3 ml of 50% (NH 4 ) 2 HPO 4  (sterile filtered) were added to every 400 ml above medium. 
     AMG Trace element solution was composed of 6.8 g ZnCl 2 , 2.5 g CuSO 4 .5H 2 O, 0.24 g NiCl 2 .5H 2 O, 13.9 g FeSO 4 .7H 2 O, 13.6 g MnSO 4 .5H 2 O, 3 g Citric acid.H 2 O, and deionised water to 1000 ml. 
     LB plates were composed of 10 g of Bacto-tryptone, 5 g of yeast extract, 10 g of sodium chloride, 15 g of Bacto-agar, and deionised water to 1000 ml. 
     LB medium was composed of 1 g of Bacto-tryptone, 5 g of yeast extract, and 10 g of sodium chloride, and deionised water to 1000 ml. 
     COVE sucrose plates were composed of 342 g of sucrose, 20 g of agar powder, 20 ml of COVE salt solution, and deionized water to 1 liter. The medium was sterilized by autoclaving at 15 psi for 15 minutes. For the transformation of MT3568, 10 mM acetamide was added, when the medium was cooled to 60° C. 
     COVE-2 plate/tube for isolation: 30 g/L sucrose, 20 ml/L COVE salt solution, 10 mM acetamide (only for the transformants of MT3568), 30 g/L noble agar (Difco, Cat #214220). 
     COVE salt solution was composed of 26 g of MgSO 4 .7H 2 O, 26 g of KCL, 26 g of KH 2 PO 4 , 50 ml of COVE trace metal solution, and deionised water to 1000 ml. 
     COVE trace metal solution was composed of 0.04 g of Na 2 B 4 O 7 .10H 2 O, 0.4 g of CuSO 4 .5H 2 O, 1.2 g of FeSO 4 .7H 2 O, 0.7 g of MnSO 4 H 2 O, 0.8 g of Na 2 MoO 4 .2H 2 O, 10 g of ZnSO 4 .7H 2 O, and deionised water to 1000 ml. 
     The SOD genes derived from fungal strains isolated from environmental samples by standard microbiological isolation techniques. Strains were identified, and taxonomy was assigned based on DNA sequencing of the ITS 
     
       
         
           
               
               
               
             
               
                   
                   
               
               
                   
                 SEQ ID 
                 Donor scientific name 
               
               
                   
                   
               
             
            
               
                   
                 SEQ ID NO 9 
                   Westerdykella  sp. AS85-2 
               
               
                   
                 SEQ ID NO 10 
                   Aspergillus  sp. XZ2669 
               
               
                   
                 SEQ ID NO 11 
                 
                   Preussia terricola 
                 
               
               
                   
                 SEQ ID NO 12 
                   Kionochaeta  sp. 
               
               
                   
                 SEQ ID NO 13 
                   Kionochaeta  sp. 
               
               
                   
                 SEQ ID NO 16 
                 
                   Preussia flanaganii 
                 
               
               
                   
                 SEQ ID NO 17 
                   Cladobotryum  sp. 
               
               
                   
                 SEQ ID NO 18 
                   Cladobotryum  sp. 
               
               
                   
                 SEQ ID NO 19 
                   Westerdykella  sp-46156 
               
               
                   
                 SEQ ID NO 20 
                 
                   Trichoderma hamatum 
                 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                   
               
               
                   
                 SEQ ID 
                 Donor scientific name 
               
               
                   
                   
               
             
            
               
                   
                 SEQ ID NO 14 
                 
                   Metapochonia bulbillosa 
                 
               
               
                   
                 SEQ ID NO 15 
                   Xylomelasma  sp. XZ0718 
               
               
                   
                 SEQ ID NO 22 
                 
                   Cephalotrichiella penicillata 
                 
               
               
                   
                 SEQ ID NO 23 
                 
                   Chaetomium megalocarpum 
                 
               
               
                   
                 SEQ ID NO 24 
                   Chaetomium thermophilum  var.  thermophilum   
               
               
                   
                 SEQ ID NO 25 
                 
                   Humicola hyalothermophila 
                 
               
               
                   
                 SEQ ID NO 26 
                 
                   Subramaniula anamorphosa 
                 
               
               
                   
                 SEQ ID NO 28 
                 
                   Trichoderma rossicum 
                 
               
               
                   
                 SEQ ID NO 29 
                 
                   Trichoderma lixii 
                 
               
               
                   
                 SEQ ID NO 30 
                   Trichoderma  sp-54723 
               
               
                   
                 SEQ ID NO 31 
                 
                   Aspergillus niveus 
                 
               
               
                   
                 SEQ ID NO 32 
                 
                   Aspergillus templicola 
                 
               
               
                   
                 SEQ ID NO 33 
                   Pochonia chlamydosporia  var.  spinulospora   
               
               
                   
                 SEQ ID NO 34 
                   Trichoderma  sp-44174 
               
               
                   
                 SEQ ID NO 35 
                 
                   Trichoderma rossicum 
                 
               
               
                   
                 SEQ ID NO 36 
                 
                   Trichoderma rossicum 
                 
               
               
                   
                 SEQ ID NO 37 
                   Trichoderma  sp-54723 
               
               
                   
                 SEQ ID NO 39 
                   Trichoderma  sp-44174 
               
               
                   
                 SEQ ID NO 40 
                 
                   Metapochonia suchlasporia 
                 
               
               
                   
                 SEQ ID NO 41 
                 
                   Metarhizium marquandii 
                 
               
               
                   
                 SEQ ID NO 42 
                 
                   Diaporthe nobilis 
                 
               
               
                   
                 SEQ ID NO 43 
                   Tolypocladium  sp. XZ2627 
               
               
                   
                 SEQ ID NO 44 
                 
                   Aspergillus japonicus 
                 
               
               
                   
                 SEQ ID NO 45 
                   Metarhizium  sp. XZ2431 
               
               
                   
                   
               
            
           
         
       
     
     Chromosomal DNA from individual strains was isolated by QIAamp Dneasy Kit (Qiagen, Hilden, Germany). 5 μg of chromosomal DNA were sent for full genome sequencing using Illumina technology. Genome sequencing, the subsequent assembly of reads and the gene discovery (i.e. annotation of gene functions) is known to the person skilled in the art and the service can be purchased commercially. 
     The genome sequences were analyzed for putative SOD from the PFAM database families PF00880, PF00881 and PF02777. This analysis identified genes encoding putative SOD, which were subsequently cloned and recombinantly expressed in  Aspergillus oryzae.    
     The SOD genes were amplified by PCR respectively from above isolated genomic DNA. The purified PCR product was cloned into the previously digested pCaHj505 (for the genes listed in Table 1) or pDAU724 (for the genes listed in Table 2) by ligation with an IN-FUSION™ CF Dry-down Cloning Kit (Clontech Laboratories, Inc., Mountain View, Calif., USA) according to the manufacturer&#39;s instructions. The ligation mixture was used to transform  E. coli  TOP10 chemically competent cells (described in Strains). Correct colonies containing the corresponding SOD gene was selected and verified by DNA sequencing (by SinoGenoMax Company Limited, Beijing, China). The correct SOD containing colony was cultivated overnight in 3 ml of LB medium supplemented with 100 μg of ampicillin per ml. Plasmid DNA was purified using a Qiagen Spin Miniprep kit (Cat. 27106) (QIAGEN GmbH, Hilden, Germany) according to the manufacturer&#39;s instructions. 
     Protoplasts of  Aspergillus oryzae  MT3568 were prepared according to WO95/002043. Protoplasts of  Aspergillus oryzae  DAU785 were prepared according to WO2018/113745. 100 μl of protoplasts were mixed with 2.5-10 μg of the  Aspergillus  expression vector (above extracted plasmid) comprising the SOD gene and 250 μl of 60% PEG 4000, 10 mM CaCl 2 , and 10 mM Tris-HCl pH7.5 and gently mixed. The mixture was incubated at 37° C. for 30 minutes and the protoplasts were spread onto COVE sucrose plates for selection. After incubation for 4-7 days at 37° C. spores of 4 transformants were inoculated into 3 ml of Dap4C medium. 
     After 3 days cultivation at 30° C., the culture broths were analyzed by SDS-PAGE using Novex® 4-20% Tris-Glycine Gel (Invitrogen Corporation, Carlsbad, Calif., USA) to identify the transformants producing the largest amount of recombinant SOD with respective estimated mature peptide size. 
     Spores of the best expressed transformant were spread on COVE-2 plates for re-isolation in order to isolate single colonies. Then a single colony was spread on a COVE-2 tube until sporulation. 
     Spores from the best expressed transformant were cultivated in 2400 ml of Dap4C medium in shake flasks during 3 days at a temperature of 30° C. under 80 rpm agitation. Culture broth was harvested by filtration using a 0.22 μm filter device. The filtered fermentation broth was used for enzyme characterization. 
     Example 7 Cloning and Expression of Fungal Superoxide Dismutase 
     Strains 
       Escherichia coli  Top-10 strain purchased from Invitrogen (Thermofisher Inc.) was used to propagate our expression vector. 
       Aspergillus oryzae  strain MT3568 (described in WO2015040159) was used for heterologous expression of the genes described in Table 1. 
     Media 
     DAP4C medium is composed of 11 g MgSO 4 .7H 2 O, 1 g KH 2 PO 4 , 2.2 g Citric acid.H 2 O, 20 g glucose, 10 g maltose, 5.2 g K 3 PO 4 .H 2 O, 0.5 g yeast extract, 1.25 g CaCO 3 , 0.5 ml AMG Trace element solution and deionized water to 1 liter. After autoclaving, 3.3 ml of 20% Lactic Acid (autoclaved) and 9.3 ml of 50% (NH 4 ) 2 HPO 4  (sterile filtered) are added to every 400 ml of the above medium. 
     AMG Trace element solution is composed of 6.8 g ZnCl 2 , 2.5 g CuSO 4 .5H 2 O, 0.24 g NiCl 2 .5H 2 O, 13.9 g FeSO 4 .7H 2 O, 13.6 g MnSO 4 .5H 2 O, 3 g Citric acid.H 2 O, and deionised water to 1000 ml. 
     LB plates are composed of 10 g of Bacto-tryptone, 5 g of yeast extract, 10 g of sodium chloride, 15 g of Bacto-agar, and deionised water to 1000 ml. 
     LB medium is composed of 1 g of Bacto-tryptone, 5 g of yeast extract, and 10 g of sodium chloride, and deionised water to 1000 ml. 
     COVE sucrose plates are composed of 342 g of sucrose, 20 g of agar powder, 20 ml of COVE salt solution, and deionized water to 1 liter. The medium was sterilized by autoclaving. For the transformation of MT3568, 10 mM acetamide was added, when the medium was cooled to 60° C. 
     COVE-2 plate/tube for isolation if single transformants: 30 g/L sucrose, 20 ml/L COVE salt solution, 10 mM acetamide, 30 g/L noble agar (Difco, Cat #214220). 
     COVE salt solution is composed of 26 g of MgSO 4 .7H 2 O, 26 g of KCL, 26 g of KH 2 PO 4 , 50 ml of COVE trace metal solution, and deionised water to 1000 ml. 
     COVE trace metal solution is composed of 0.04 g of Na 2 B 4 O 7 .10H 2 O, 0.4 g of CuSO 4 .5H 2 O, 1.2 g of FeSO 4 .7H 2 O, 0.7 g of MnSO 4 H 2 O, 0.8 g of Na 2 MoO 4 .2H 2 O, 10 g of ZnSO 4 .7H 2 O, and deionised water to 1000 ml. 
     Cloning, Expression and Fermentation of Fungal SOD Enzymes 
     The SOD genes were derived from fungal strains isolated from environmental samples using standard microbiological isolation techniques. The donor strains HEAL7057, HEAL7058 and HEAL7059 were identified, and taxonomy assigned based on the DNA sequencing of the ITS (Table 1). The donor fungal organism for HEAL7007 was  Trichoderma reesei  QM6a, a publicly available strain originally isolated from the Solomon Islands and is available in collections such as ATCC (ATCC 13631). 
     Chromosomal DNA from individual strains was isolated by QIAamp Dneasy Kit (Qiagen, Hilden, Germany). 5 μg of each genomic DNA sample were sent for full genome sequencing using Illumina technology. Genome sequencing, the subsequent assembly of reads and the gene discovery (i.e. annotation of gene functions) is known to persons skilled in the art and the service can also be purchased commercially. 
     The genome sequences were BLAST analyzed for putative SOD from the PFAM database families PF00080. This analysis identified genes encoding putative SOD, which were subsequently cloned and recombinantly expressed in  Aspergillus oryzae.    
     The SOD genes were amplified by PCR respectively from above isolated genomic DNA. The purified PCR products were cloned into the previously digested pDau109 by ligation with an IN-FUSION™ CF Dry-down Cloning Kit (Clontech Laboratories, Inc., Mountain View, Calif., USA) according to the manufacturer&#39;s instructions. The plasmid pDAu109 and its use are described in (WO 2005/042735). The ligation mixture was used to transform  E. coli  TOP10 chemically competent cells (described in Strains). The cloned genes were sequenced and confirmed to be identical to the corresponding genes found in the genome sequences and transformed into the  Aspergillus oryzae  strain MT3568 (WO 11/057140) by the methods described in Christensen et al., 1988, Biotechnology 6, 1419-1422 and WO 04/032648. Transformants were selected during regeneration from protoplasts based on the ability, conferred by a selectable marker in the expression vector, to utilize acetamide as a nitrogen source, and were subsequently re-isolated under selection. 
     Production of the recombinant SOD peptides was evaluated by culturing the transformants in 96-well deep-well microtiter plates for 4 days at 30° C. in either a 0.25 ml or 0.75 ml volume of either or both YPG medium (WO 05/066338) or DAP-4C-1 medium (WO 12/103350) and monitoring peptide expression by SDS-PAGE. A single  Aspergillus  transformant was selected for each gene based on expression yields as evaluated in microtiter plate fermentation. 
     Spores of the best expressed transformant were spread on COVE-2 plates for re-isolation in order to isolate single colonies. Then a single colony was spread on a COVE-2 tube until sporulation. 
     For larger-scale production of the recombinant enzymes, and the  Aspergillus  transformants were cultured in 500 ml baffled flasks containing 150 ml of fermentation medium. Transformants expressing the SOD peptides were fermented in DAP-4C-1 medium (WO 12/103350). The cultures were shaken on a rotary table at 150 RPM at for 4 days, and the broth was subsequently separated from cellular material by passage through a 0.22 um filtration unit. 
     Example 8 SOD Purification 
     The purification process for SOD was firstly applied with hydrophobic interaction chromatography, then if needed, ion exchange chromatography was applied. The difference for all the molecules was buffer type, pH, and salt concentration. 
     The culture supernatant of recombinant SOD was firstly added by ammonium sulfate with a final concentration of 2.2M and loaded into Phenyl Sepharose High Performance (GE Healthcare) equilibrated with 20 mM Tris-HCl at pH7.0 with 2.2M ammonium sulfate added. A gradient decrease of ammonium sulfate concentration from 2.2M to 0 was set up as elution condition. The elution fractions and flow-through faction were assayed by SDS-PAGE. The SOD activity was determined by the relative activity method of the SOD activity assay kit from Sigma (Cat No. 19160) described as below. 
     If the purity of enzyme purified by first step was not good and contains several bands, ion exchange chromatography will be applied for further purification. The fractions with SOD activity were pooled together and dialyzed with 20 mM Tris-HCl at pH7.0, then loaded into a Mono Q or Capto Q column (GE Healthcare) equilibrated with 20 mM Tris-HCl pH7.0. A gradient increase of NaCl concentration from 0 to 1M with 20 mM Tris-HCl at pH7.0 was set up as elution buffer. The elution fractions and flow-through fraction were assayed for SDS-PAGE and SOD activity. 
     The fractions with enzyme activity were pooled together and then diafiltrated with 20 mM Tris-HCl at pH7.0. The protein concentration was determined by Qubit® Protein Assay Kit (Invitrogen, cat Q33212). 
     Example 9 SOD Activity Assay 
     SOD activity was determined using the relative active method of the SOD activity assay kit from Sigma (Cat No. 19160). 20 μl SOD with different dilution times by MQ water and 0.01% Triton X-100 was added into 200 μl WST solution (prepared as described for SOD activity assay kit), then 20 μl coupled enzyme solution from kit was added. The mixture was measured at 450 nm for 20 minutes at 37° C. (interval 40 sec, shake before first read). One slope could be created with mOD/min vs enzyme dosage, which could be set as standard curve for each SOD. Two commercial SODs from Sigma®, recombinant SOD bovine expressed in  Escherichia coli  (S9697) with 6108 U/mg EP and SOD from  E. coli  (S5639) with 10240 U/mg EP were set as specific activity reference. 
     Since the pH of WST working solution was about 10, the SOD activity at alkaline condition might be very low. The SOD activity assay was later adjusted by at pH7.8, which WST solution was replaced by Cytochrome C solution at pH7.8 (Cytochrome C, Sigma-Aldrich C7752). The Cytochrome C working solution contains 50 mM PBS at pH7.8, 0.1 mM EDTA, 0.01 mM CytoC, and 0.05 mM Xanthine (Sigma-Aldrich X0626). The absorbance of mixture was measured at 550 nm. 
     Example 10 Gastric Stability Assay of SODs 
     Gastric stability was assayed with artificial gastric juice as stress condition. 20 μl SOD with appropriate dilution was added into 180 μl stress buffer (100 mM NaCl, 0.0013M HCl at pH3.0). The stress buffer with pepsin was prepared by adding 1.11 mg/ml pepsin (from porcine gastric mucosa, P7000, Sigma, 474 U/mg). The mixture was incubated at 37° C. in thermomixer for 0, 15, 30, 45, 60, 90, and 120 minutes separately. 10 μl sample extracted from the mixture was added into 90 μl activity buffer (K 2 HPO 4 /KH2PO4 mixed with final concentration of 100 mM PBS at pH7.0) as stop mixture. Then 20 μl stop mixture was added into 200 μl WST solution (or CytoC solution at pH7.8), and finally 20 μl coupled enzyme solution from kit was added to measure absorbance. The absorbance was measured at 450 nm for Sigma SOD kit (or 550 nm at pH 7.8) for 20 minutes at 37° C. (interval 40 sec, shake before first read). The activity at pH7.0 without stress condition was set as reference, and the residual activity at stress condition (pH3.0, pH3.0+pepsin) compared with reference was calculated as relative stability. 
     
       
         
           
               
               
               
             
               
                   
               
               
                   
                 Gastric stability: 
                 Gastric stability: 
               
               
                   
                 pH 3, +pepsin 15 min - 
                 pH 3, +pepsin 30 min - 
               
               
                 ID 
                 residual activity value % 
                 residual activity value % 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 SOD, sigma 
                 35 
                 26 
               
               
                 r  E. coli   
                 43 
                 43 
               
               
                 SEQ ID NO 1 
                 98 
                 99 
               
               
                 SEQ ID NO 10 
                 81 
                 83 
               
               
                 SEQ ID NO 11 
                 70 
                 75 
               
               
                 SEQ ID NO 12 
                 88 
                 88 
               
               
                 SEQ ID NO 13 
                 92 
                 89 
               
               
                 SEQ ID NO 14 
                 100 
                 100 
               
               
                 SEQ ID NO 15 
                 100 
                 100 
               
               
                 SEQ ID NO 16 
                 90 
                 92 
               
               
                 SEQ ID NO 17 
                 100 
                 100 
               
               
                 SEQ ID NO 18 
                 100 
                 100 
               
               
                 SEQ ID NO 19 
                 52 
                 53 
               
               
                 SEQ ID NO 20 
                 98 
                 97 
               
               
                 SEQ ID NO 22 
                 84 
                 85 
               
               
                 SEQ ID NO 23 
                 45 
                 45 
               
               
                 SEQ ID NO 24 
                 57 
                 58 
               
               
                 SEQ ID NO 25 
                 62 
                 62 
               
               
                 SEQ ID NO 26 
                 97 
                 97 
               
               
                 SEQ ID NO 27 
                 78 
                 81 
               
               
                 SEQ ID NO 28 
                 128 
                 122 
               
               
                 SEQ ID NO 29 
                 144 
                 126 
               
               
                 SEQ ID NO 30 
                 124 
                 125 
               
               
                 SEQ ID NO 31 
                 126 
                 140 
               
               
                 SEQ ID NO 32 
                 90 
                 90 
               
               
                 SEQ ID NO 33 
                 105 
                 90 
               
               
                 SEQ ID NO 34 
                 120 
                 127 
               
               
                 SEQ ID NO 35 
                 101 
                 113 
               
               
                 SEQ ID NO 36 
                 96 
                 96 
               
               
                 SEQ ID NO 37 
                 100 
                 105 
               
               
                 SEQ ID NO 38 
                 98 
                 92 
               
               
                 SEQ ID NO 39 
                 104 
                 116 
               
               
                 SEQ ID NO 40 
                 83 
                 88 
               
               
                 SEQ ID NO 41 
                 118 
                 116 
               
               
                 SEQ ID NO 42 
                 98 
                 99 
               
               
                 SEQ ID NO 43 
                 109 
                 107 
               
               
                 SEQ ID NO 44 
                 104 
                 116 
               
               
                 SEQ ID NO 45 
                 104 
                 111 
               
               
                 SEQ ID NO 46 
                 79 
                 77 
               
               
                 SEQ ID NO 47 
                 41 
                 42 
               
               
                 SEQ ID NO 48 
                 61 
                 60 
               
               
                   
               
            
           
         
       
     
     As can be seen from the Table, the SODs of the invention are surprisingly gastric stable compared to conventional and commercial SODs. 
     Example 11 Thermal Stability Assay of SODs 
     Thermal stability was quantified utilizing nano differential scanning fluorimetry (nDSF). To adjust pH, the samples were diluted 10-fold in a buffer cocktail containing 50 mM 2-(N-Morpholin)ethansulfonsyre (MES), 50 mM glycine, 50 mM acetic acid, pH 3-11. Sample dilutions were conducted using a Hamilton Microlab STAR Liquid Handling System in 96-well microtiter plates and transferred to 384-well microplates. The nDSF experiments were conducted utilizing either a Prometheus NT.48 or Prometheus NT.Plex with autosampler from Nanotemper. With the Prometheus NT.48, the samples were loaded manually using single capillaries (PR-0002), while samples were loaded in the Prometheus NT.Plex using capillary chips (PR-A0002). The experiments were conducted from 20 to 95° C. with a temperature gradient of 3.3° C./min. The transition temperatures (T m -values) were obtained from peak values derived from the first-derivative of the signal trace (350/330 nm fluorescence ratio or 330 nm fluorescence) using PR. ThermControl software. 
     Example 12 Catalase Cloning and Expression 
     Strains 
       Escherichia coli  Top-10 strain purchased from Invitrogen (Thermofisher Inc.) was used to propagate our expression vector. 
       Aspergillus oryzae  strain MT3568 (described in WO2015040159) was used for heterologous expression of the genes described in Table 1. 
     Media 
     DAP4C medium is composed of 11 g MgSO 4 .7H 2 O, 1 g KH 2 PO 4 , 2.2 g Citric acid.H 2 O, 20 g glucose, 10 g maltose, 5.2 g K 3 PO 4 H 2 O, 0.5 g yeast extract, 1.25 g CaCO 3 , 0.5 ml AMG Trace element solution and deionized water to 1 liter. After autoclaving, 3.3 ml of 20% Lactic Acid (autoclaved) and 9.3 ml of 50% (NH 4 ) 2 HPO 4  (sterile filtered) are added to every 400 ml of the above medium. 
     AMG Trace element solution is composed of 6.8 g ZnCl 2 , 2.5 g CuSO 4 .5H 2 O, 0.24 g NiCl 2 .5H 2 O, 13.9 g FeSO 4 .7H2O, 13.6 g MnSO 4 .5H 2 O, 3 g Citric acid.H 2 O, and deionised water to 1000 ml. 
     LB plates are composed of 10 g of Bacto-tryptone, 5 g of yeast extract, 10 g of sodium chloride, 15 g of Bacto-agar, and deionised water to 1000 ml. 
     LB medium is composed of 1 g of Bacto-tryptone, 5 g of yeast extract, and 10 g of sodium chloride, and deionised water to 1000 ml. 
     COVE sucrose plates are composed of 342 g of sucrose, 20 g of agar powder, 20 ml of COVE salt solution, and deionized water to 1 liter. The medium was sterilized by autoclaving. For the transformation of MT3568, 10 mM acetamide was added, when the medium was cooled to 60° C. 
     COVE-2 plate/tube for isolation if single transformants: 30 g/L sucrose, 20 ml/L COVE salt solution, 10 mM acetamide, 30 g/L noble agar (Difco, Cat #214220). 
     COVE salt solution is composed of 26 g of MgSO 4 .7H 2 O, 26 g of KCL, 26 g of KH 2 PO 4 , 50 ml of COVE trace metal solution, and deionised water to 1000 ml. 
     COVE trace metal solution is composed of 0.04 g of Na 2 B 4 O 7 .10H 2 O, 0.4 g of CuSO 4 .5H 2 O, 1.2 g of FeSO 4 .7H 2 O, 0.7 g of MnSO 4 H 2 O, 0.8 g of Na 2 MoO 4 .2H 2 O, 10 g of ZnSO 4 .7H 2 O, and deionised water to 1000 ml. 
     Example 12: Cloning, Expression and Fermentation of Fungal Catalase Enzymes 
     The catalase genes were derived from fungal strains isolated from environmental samples using standard microbiological isolation techniques. The donor strains HEAL7001, was identified, and taxonomy assigned based on the DNA sequencing of the ITS (Table 1). The donor fungal organism for HEAL7060 was  Curvularia verruculosa , a publicly available strain originally isolated from a grass inflorescence in The Gambian Republic, Africa. The strain was originally collected in 1966 : Curvularia verruculosa  Tandon &amp; Bilgrami ex M. B. Ellis, Mycological Papers 106: 20 (1966). 
     Chromosomal DNA from individual strains was isolated by QIAamp Dneasy Kit (Qiagen, Hilden, Germany). 5 μg of each genomic DNA sample were sent for full genome sequencing using Illumina technology. Genome sequencing, the subsequent assembly of reads and the gene discovery (i.e. annotation of gene functions) is known to persons skilled in the art and the service can also be purchased commercially. 
     The genome sequences were BLAST analyzed for putative catalase from the PFAM database families PF00199 and PF18011. This analysis identified genes encoding putative catalases, which were subsequently cloned and recombinantly expressed in  Aspergillus oryzae.    
     The catalase genes were amplified by PCR respectively from above isolated genomic DNA. The purified PCR products were cloned into the previously digested pDau109 by ligation with an IN-FUSION™ CF Dry-down Cloning Kit (Clontech Laboratories, Inc., Mountain View, Calif., USA) according to the manufacturer&#39;s instructions. The plasmid pDAu109 and its use are described in (WO 2005/042735). The ligation mixture was used to transform  E. coli  TOP10 chemically competent cells (described in Strains). The cloned genes were sequenced and confirmed to be identical to the corresponding genes found in the genome sequences and transformed into the  Aspergillus oryzae  strain MT3568 (WO 11/057140) by the methods described in Christensen et al., 1988, Biotechnology 6, 1419-1422 and WO 04/032648. Transformants were selected during regeneration from protoplasts based on the ability, conferred by a selectable marker in the expression vector, to utilize acetamide as a nitrogen source, and were subsequently re-isolated under selection. 
     Production of the recombinant catalase peptides was evaluated by culturing the transformants in 96-well deep-well microtiter plates for 4 days at 30° C. in either a 0.25 ml or 0.75 ml volume of either or both YPG medium (WO 05/066338) or DAP-4C-1 medium (WO 12/103350) and monitoring peptide expression by SDS-PAGE. A single  Aspergillus  transformant was selected for each gene based on expression yields as evaluated in microtiter plate fermentation. 
     Spores of the best expressed transformant were spread on COVE-2 plates for re-isolation in order to isolate single colonies. Then a single colony was spread on a COVE-2 tube until sporulation. 
     For larger-scale production of the recombinant enzymes, and the  Aspergillus  transformants were cultured in 500 ml baffled flasks containing 150 ml of fermentation medium. Transformants expressing the catalase peptides were fermented in DAP-4C-1 medium (WO 12/103350). The cultures were shaken on a rotary table at 150 RPM at for 4 days, and the broth was subsequently separated from cellular material by passage through a 0.22 um filtration unit. 
     Example 13: Catalase Activity Assay 
     The catalase from Bovine Liver (Sigma®, Enzyme Commission (EC) Number: 1.11.1.6, CAS Number: 9001-05-2, Molecular weight: 250 kDa) has an activity of 3524 U/mg EP. Catalase activity was determined by H 2 O 2  reduction detected at 240 nm. Firstly, catalase was diluted with different dilution times by MQ water and 0.01% Triton X-100. 10 μl enzyme sample, 90 μl activity buffer (K 2 HPO 4 /KH 2 PO 4  mixed with final concentration of 100 mM PBS at pH7.0) were added into 50 μl 0.2% H 2 O 2  solution (30% H 2 O 2  was diluted to 0.2% in activity buffer). The mixture was measured at 240 nm for 10 minutes at room temperature (interval 34 sec, shake before first read). The commercial catalase from Sigma®, catalase from bovine liver (C1345), was set as reference. This allows for the selection of the suitable enzyme dosage. 
     
       
         
           
               
               
               
               
             
               
                   
               
               
                   
                 Mature 
                 Full length 
                 Relative 
               
               
                   
                 polypeptide 
                 polypeptide 
                 Activity 
               
               
                 Source 
                 SEQ ID NO 
                 SEQ ID NO 
                 U/mg EP 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Talaromyces 
                 SEQ ID NO 
                 SEQ ID NO 
                 1667 
               
               
                 stipitatus 
                 105 
                 153 
               
               
                 Penicillium 
                 SEQ ID NO 
                 SEQ ID NO 
                 8265 
               
               
                 emersonii 
                 108 
                 156 
               
               
                 Penicillium 
                 SEQ ID NO 
                 SEQ ID NO 
                 30953 
               
               
                 oxalicum 
                 116 
                 164 
               
               
                 Thermoascus 
                 SEQ ID NO 
                 SEQ ID NO 
                 10919 
               
               
                 crustaceus 
                 118 
                 166 
               
               
                 Thermothelomyces 
                 SEQ ID NO 
                 SEQ ID NO 
                 18314 
               
               
                 thermophilus 
                 112 
                 160 
               
               
                 Curvularia 
                 SEQ ID NO 
                 SEQ ID NO 
                 20836 
               
               
                 verruculosa 
                 113 
                 161 
               
               
                 
                   Aspergillus oryzae 
                 
                 SEQ ID NO 
                 SEQ ID NO 
                 43975 
               
               
                 (NN051131) 
                 115 
                 163 
               
               
                 
                   Aspergillus 
                 
                 SEQ ID NO 
                 SEQ ID NO 
                 52327 
               
               
                 
                   lentulus 
                 
                 104 
                 152 
               
               
                 
                   Aspergillus 
                 
                 SEQ ID NO 
                 SEQ ID NO 
                 51648 
               
               
                 
                   fumigatus 
                 
                 111 
                 159 
               
               
                 Neurospora crassa 
                 SEQ ID NO 
                 SEQ ID NO 
                 8651 
               
               
                   
                 123 
                 171 
               
               
                 Neurospora crassa 
                 SEQ ID NO 
                 SEQ ID NO 
                 51184 
               
               
                   
                 121 
                 169 
               
               
                 Malbranchea 
                 SEQ ID NO 
                 SEQ ID NO 
                 82637 
               
               
                 cinnamomea 
                 106 
                 154 
               
               
                 
                   Humicola 
                 
                 SEQ ID NO 
                 SEQ ID NO 
                 56454 
               
               
                 
                   hyalothermophila 
                 
                 117 
                 165 
               
               
                 Thielavia 
                 SEQ ID NO 
                 SEQ ID NO 
                 5273 
               
               
                 australiensis 
                 119 
                 167 
               
               
                 Thermomucor 
                 SEQ ID NO 
                 SEQ ID NO 
                 7750 
               
               
                 indicae-seudaticae 
                 110 
                 158 
               
               
                 Crassicarpon 
                 SEQ ID NO 
                 SEQ ID NO 
                 39459 
               
               
                 thermophilum 
                 107 
                 155 
               
               
                   
               
            
           
         
       
     
     Example 14: Gastric Stability Assay for Catalase 
     Gastric stability was assayed with artificial gastric juice as stress condition. 100 catalase with appropriate dilution was added into 900 stress buffer (100 mM NaCl, 0.0013M HCl at pH3.0). The stress buffer with pepsin was prepared by adding 1.11 mg/ml pepsin (from porcine gastric mucosa, P7000, Sigma, 474 U/mg) as pH3+pepsin buffer, and also was incubated with 10 ul catalase. The mixture was incubated at 37° C. in thermomixer for 0, 30, 60 and 90 minutes separately. 10 μl sample extracted from the mixture was added into 90 μl activity buffer as stop mixture. Then 100 μl stop mixture was added with 50 μl 0.2% H 2 O 2  solution to measure absorbance. The absorbance was measured at 240 nm for 10 minutes at room temperature (interval 34 sec, shake before first read). One slop could be calculated by OD vs min, which presents the activity. The activity at pH7.0 without stress condition was set as reference, and the residual activity at stress condition (pH3.0 or pH3.0+pepsin) compared with reference was calculated as relative stability. 
     
       
         
           
               
               
             
               
                   
               
               
                   
                 Gastric stability: pH 3, +pepsin 
               
               
                 Catalase SEQ ID NO 
                 30 min - residual value % 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 SEQ ID NO 109 
                 55 
               
               
                 SEQ ID NO 126 
                 65 
               
               
                 SEQ ID NO 7 
                 85 
               
               
                 Terminox Ultra ™ (SEQ ID NO 250) 
                 95 
               
               
                 SEQ ID NO 105 
                 97 
               
               
                 SEQ ID NO 108 
                 85 
               
               
                 SEQ ID NO 116 
                 98 
               
               
                 SEQ ID NO 105 
                 81 
               
               
                 SEQ ID NO 112 
                 97 
               
               
                 SEQ ID NO 115 
                 77 
               
               
                 SEQ ID NO 104 
                 82 
               
               
                 SEQ ID NO 111 
                 46 
               
               
                 SEQ ID NO 117 
                 97 
               
               
                 SEQ ID NO 107 
                 100 
               
               
                 SEQ ID NO 110 
                 100 
               
               
                 SEQ ID NO 123 
                 100 
               
               
                 Catalase ™ (SEQ ID NO 7) 
                 39