Patent Publication Number: US-2021162188-A1

Title: Intra-cavity circulation heat perfusion apparatus

Description:
TECHNICAL FIELD 
     The present disclosure relates to the technical field of medical instruments, and more particularly, to a device of intracavitary circulatory hyperthermic perfusion. 
     BACKGROUND 
     Bladder cancer is the most common tumor of the urinary system. In China, the new patient with bladder cancer is about  6  ten thousand per year, ranking seventh among male malignancies. The bladder cancer is classified into: a non-muscle invasive bladder cancer and a muscle invasive bladder cancer, and the non-muscle invasive bladder cancer is characterized by high recurrence and low progression. The treatment of the non-muscle invasive bladder cancer is usually a surgical treatment, and a transurethral resection of bladder tumor (TURBT) is mainly used. The non-muscle invasive bladder cancer has a high postoperative recurrence rate, and 20% to 70% of patients relapse within one year after TURBT. A perfusion treatment after TURBT is a very important means for preventing recurrence. 
     The perfusion treatment device can be applied to the bladder for treatment, and can also be applied to the chest cavity, the abdominal cavity, the pelvis cavity, the rectum and the like for treatment. When a conventional perfusion treatment device is used for treating the bladder, a perfusion treatment device is used for a normal temperature perfusion after a resection operation of the bladder tumor. 50 mg of pirarubicin is dissolved in 50 ml of normal saline to prepare a medicinal solution, and then the medicinal solution is extracted with a syringe and is injected into the bladder of a patient through a urinary catheter. The medicinal solution is discharged after staying in the bladder of the patient for 45 min to 60 min. However, the conventional perfusion treatment device has a poor treatment effect. 
     SUMMARY 
     Based on this, in view of the aforementioned technical problems, it is necessary to provide a device of intracavitary circulatory hyperthermic perfusion that can effectively improve the treatment effect. 
     A device of intracavitary circulatory hyperthermic perfusion includes: 
     a housing; 
     an electromagnetic induction heating device disposed on the housing, the electromagnetic induction heating device including a tray and an electromagnetic induction coil, the electromagnetic induction coil being disposed on one side of the tray and configured to heat a heating tank capable of being carried on the tray; 
     a controller including a main control unit, a data acquisition unit, and a power control unit, wherein the data acquisition unit and the power control unit are electrically coupled to the main control unit, the data unit is configured to acquire temperature values of a medicinal solution in the heating tank, a liquid outlet pipeline, and a liquid return pipeline and to transmit the temperature values to the main control unit, and the main control unit controls the power control unit according to the temperature values of the medicinal solution to control a heating power of the electromagnetic induction coil. 
     The aforementioned device of intracavitary circulatory hyperthermic perfusion has at least the following advantages. 
     The tray is configured to carry the heating tank. During operation, the main control unit of the controller controls the electromagnetic induction coil to be energized to heat the heating tank, thereby indirectly heating the medicinal solution in the liquid storage cavity to raise the temperature of the medicinal solution. The data acquisition unit is configured to acquire the temperature values of the medicinal solution in the heating tank, the liquid outlet pipeline, and the liquid return pipeline and to transmit the temperature values to the main control unit, and the main control unit controls the power control unit according to the temperature values of the medicinal solution to control the heating power of the electromagnetic induction coil. When the temperature of the medicinal solution reaches a predetermined temperature, the temperature is kept constant. The medicinal solution is heated to the predetermined temperature before being introduced into the bladder for treatment, thus, after the liquid medicine is introduced into the bladder, a thermal killing mechanism can be fully exerted, metastatic cancer cells that are widely planted on serosa are killed, the lesions that cause the malignant effusion can be eliminated, so that the purpose of effectively treating the cancerous effusion is achieved, and the treatment effect is effectively improved. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is a schematic view of a device of intracavitary circulatory hyperthermic perfusion in accordance with an embodiment; 
         FIG. 2  is a partial schematic view of  FIG. 1 ; 
         FIG. 3  is a partial schematic view of  FIG. 2 ; 
         FIG. 4  is a partially enlarged view of an A-portion shown in  FIG. 2 ; 
         FIG. 5  is a partial schematic view of  FIG. 3 ; 
         FIG. 6  is a schematic view of a circulation pipeline for hyperthermic perfusion of  FIG. 1 ; 
         FIG. 7  is a partial schematic view of  FIG. 6 ; 
         FIG. 8  is another partial schematic view of  FIG. 6 ; 
         FIG. 9  is a schematic view of a heating tank in accordance with an embodiment; 
         FIG. 10  is a partial sectional view of the heating tank of  FIG. 9 ; 
         FIG. 11  is an exploded view of the heating tank of  FIG. 9 ; 
         FIG. 12  is a schematic view of a two-way valve in accordance with an embodiment; 
         FIG. 13  is a sectional view of the two-way valve of  FIG. 12 ; 
         FIG. 14  is a schematic exploded view of the two-way valve of  FIG. 12 ; 
         FIG. 15  is a schematic view of a valve main body of  FIG. 12 ; 
         FIG. 16  is a schematic exploded view of the valve main body of  FIG. 15 ; 
         FIG. 17  is a schematic view of the valve main body of  FIG. 15  with another perspective; 
         FIG. 18  is a sectional view taken along a line B-B in  FIG. 15 ; 
         FIG. 19  is a top view of a mounting base of  FIG. 14 ; 
         FIG. 20  is a sectional view taken along a line C-C in  FIG. 19 ; 
         FIG. 21  is a schematic view illustrating a second mounting plate, an indexing positioner, and a photoelectric switch in accordance with an embodiment where the two-way valve is in an initial state; 
         FIG. 22  is a schematic view illustrating the second mounting plate, the indexing positioner, and the photoelectric switch of FIG. 10  where the two-way valve is in a non-communication state; 
         FIG. 23  is a schematic view illustrating the second mounting plate, the indexing positioner, and the photoelectric switch of FIG. 10  where the two-way valve is in a communication state; 
         FIG. 24  is a schematic exploded view of a dosing joint in accordance with an embodiment; 
         FIG. 25  is a sectional view of the dosing joint of  FIG. 24  after assembly; 
         FIG. 26  is a schematic exploded view of a cavity inlet flow indicator in accordance with an embodiment; 
         FIG. 27  is a sectional view of the cavity inlet flow indicator of  FIG. 26  after assembly; 
         FIG. 28  is a schematic exploded view of a cavity inlet thermometer in accordance with an embodiment; 
         FIG. 29  is a sectional view of the cavity inlet thermometer of  FIG. 28  after assembly; 
         FIG. 30  is a schematic exploded view of a filter in accordance with an embodiment; 
         FIG. 31  is a sectional view of the filter of  FIG. 30  after assembly. 
     
    
    
     DETAILED DESCRIPTION OF EMBODIMENTS 
     In order to make the foregoing objects, features, and advantages of the present disclosure more apparent and intelligible, specific embodiments of the present disclosure are described in detail below with reference to the accompanying drawings. Numerous specific details are set forth in the following description in order to fully understand the present disclosure. However, the present disclosure can be implemented in many other ways than those described herein, and those skilled in the art can make similar improvements without departing from the content of the present disclosure, so the present disclosure is not limited by the specific implementations disclosed below. 
     It should be noted that when an element is referred to as being “fixed to” another element, it may be directly on the other element or there may be an intermediate element. When an element is considered to be “connected” to another element, it can be directly connected to another element or connected to another element with an intermediate element. The terms “vertical”, “horizontal”, “left”, “right” and similar expressions used herein are for illustrative purposes only and are not meant to be the only implementations. 
     Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which the present disclosure belongs. The terms used in the description of the present disclosure are only for the purpose of describing specific embodiments, and are not intended to limit the present disclosure. The technical features of the embodiments described above can be arbitrarily combined. In order to simplify the description, all possible combinations of the technical features in the above embodiments have not been described. However, as long as there is no contradiction in the combinations of these technical features, all combinations should be considered within the scope of the present description. 
     Referring to  FIG. 1 , a device of intracavitary circulatory hyperthermic perfusion  10  in accordance with an embodiment is mainly used to perfuse chemotherapeutic drugs heated to a certain temperature into a body cavity, which can fully exert a thermal killing mechanism to kill metastatic cancer cells that are widely planted on serosa and to eliminate the lesions causing the malignant effusion, so that the purpose of effectively treating cancerous effusion is achieved, and the treatment effect is effectively improved. The device of intracavitary circulatory hyperthermic perfusion  10  can be applied to various body cavities such as the bladder, the chest cavity, the abdominal cavity, the pelvic cavity, or the rectum and the like, thereby achieving the purpose of improving the treatment effect. The present embodiment is mainly described in detail by taking the example of the application to the bladder  10 ′, but this does not limit the scope of the application of the device of intracavitary circulatory hyperthermic perfusion  10 . 
     Referring to  FIG. 2  and  FIG. 4  together, specifically, the device of intracavitary circulatory hyperthermic perfusion  10  includes a housing  100 , a lifting mechanism  200 , a dustproof assembly  220 , an electromagnetic induction heating device (not shown), a circulation pipeline for hyperthermic perfusion  400 , a controller (not shown), a touch display  500 , and an infusion rod  600 . The housing  100  is mainly used to carry and support. 
     An accommodating cavity  100   a  is formed in the middle of the housing  100  and penetrates through two opposite sides of the housing  100 , so that a user can directly observe components and parts in the accommodating cavity  100   a  and can directly manipulate the components and parts located in the accommodating cavity  100   a  by hand. An interior of the housing  100  is hollow. Therefore, a storage cavity  100   b  is formed in the interior of the housing  100 . A sliding groove  110  is formed on a side wall of the housing  100  and is in communication with the accommodating cavity  100   a.    
     The touch display  500  is disposed on the housing  100  and is electrically coupled to the controller. Specifically, the touch display  500  is disposed on a top of the housing  100 , a human-computer interactive operation of the device of intracavitary circulatory hyperthermic perfusion  10  can be achieved by touching the touch display  500 , thereby improving convenience. The bottom of the housing  100  is further provided with a rotating wheel  130  to improve convenience of transportation and save time and labor. The housing  100  is further provided with an infusion rod  600 , which is used for hanging a medicine solution bag  600 ′ or a medicine solution bottle. 
     Referring to  FIG. 3  and  FIG. 5  together, the lifting mechanism  200  includes a lifting assembly  210  and a lifting platform  230 . The lifting assembly  210  is disposed inside the housing  100 . The lifting assembly  210  includes a first driving source  211 , a driving shaft  212 , and a lifting block  213 . The first driving source  211  is capable of driving the lifting block  213  to move reciprocally along a lifting direction through the driving shaft  212 . 
     Specifically, in the present embodiment, the first driving source  211  is a motor, and the motor may be a stepping motor. The driving shaft  212  is a lead screw, and the lifting block  213  is rotatably disposed on the lead screw. The motor can drive the lead screw to rotate, and the lifting block  213  can rotate relative to the lead screw to realize the reciprocating movement along the lifting direction. 
     The lifting assembly  210  further includes a motor fixing base  214 , which is fixed inside the housing  100 , and the motor is mounted on the motor fixing base  214 . Since the driving shaft  212  is the lead screw, the lifting assembly  210  further includes a lead screw base  215  that is fixed inside the housing  100 . One end of the lead screw is connected to the motor through a coupler, and the other end of the lead screw is disposed on the lead screw base  215 . 
     Specifically, in the present embodiment, since the lead screw cannot be directly stressed, the lifting assembly  210  further includes a support frame  216  and a sliding rail  217 . The support frame  216  is fixed inside the housing  100 , and the support frame  216  and the sliding rail  217  are fixed on the support frame  216 . The lifting block  213  is slidably disposed on the sliding rail  217 . For example, both ends of the support frame  216  are respectively fixed on the motor fixing base  214  and the lead screw base  215 , and the support frame  216  is fixed on the housing  100  through the motor fixing base  214  and the lead screw base  215 . Therefore, the support frame  216  can be used to support the lead screw, thereby preventing the lead screw from being directly stressed. 
     Certainly, in other embodiments, the first driving source  211  may also be a cylinder. Correspondingly, the driving shaft  212  is a piston rod, and the lifting block  213  is fixed on the piston rod. The cylinder can drive the piston rod to move reciprocally along the lifting direction, so as to drive the lifting block  213  to move reciprocally along the lifting direction. Certainly, in another embodiment, the first driving source  211  may also be a motor, and the driving shaft  212  is a linear guide rail. The motor can drive the lifting block  213  to move up and down along the linear guide rail. The dustproof assembly  220  includes a lifting seat  221 , a dustproof belt  222 , an upper rolling shaft  223 , and a lower rolling shaft  224 . The lifting seat  221  is fixed on the lifting block  213  and moves along with the movement of the lifting block  213 . Both the upper rolling shaft  223  and the lower rolling shaft  224  are rotatably disposed inside the housing  100 . For example, the upper rolling shaft  223  and the lower rolling shaft  224  may be rotatably mounted inside the housing  100  by a fastener. One end of the dustproof belt  222  is fixed on the lifting seat  221 , and the other end of the dustproof belt  222  is fixed on the lifting seat  221  after passing around the upper rolling shaft  223 , passing through the lifting seat  221 , and passing around the lower rolling shaft  224 . 
     The dustproof belt  222  can be made of cloth material or made of a leather belt material. Therefore, compared with the conventional foldable dustproof structure, the dustproof belt  222  adopted in the present embodiment does not shrink, and therefore, the dustproof belt  222  does not cause the phenomenon that the dustproof structure breaks up or cannot closely adhere to the sliding groove  110  or hinders the movement of the lifting block  213  during a shrinking process. In addition, compared with the foldable organ-type enclosure cloth, the dustproof assembly  220  in the present embodiment has a smaller volume, and meets the requirements for miniaturization. The lifting seat  221  has a mounting portion exposed to the casing  100  through the sliding slot  110  of the casing  100 , and the dust-proof belt  222  is attached to the inner side wall of the casing  100  to shield the sliding slot  110 . The lifting seat  221  is provided with a mounting portion exposed to the housing  100  through the sliding groove  110  on the housing  100 , and the dustproof belt  222  abuts against an inner side wall of the housing  100  to shield the sliding groove  110 . 
     The lifting seat  221  includes a top plate  2211 , a bottom plate  2212 , a first side plate  2213  and a second side plate  2214  which are oppositely disposed. The first side plate  2213  and the second side plate  2214  are located between the top plate  2211  and the bottom plate  2212 . The top plate  2211  is provided with a first through hole  2215 , and the bottom plate  2212  is provided with a second through hole  2215 . After passing around the upper rolling shaft  223 , the dustproof belt  222  sequentially passes through the first through hole  2215  and the second through hole  2216 , and then passes around the lower rolling shaft  224 . The first side plate  2213  is fixed on the lifting block  213 , the second side plate  2214  faces the sliding groove  110 , and the mounting portion is located on the second side plate  2214 . Therefore, one side of the dustproof belt  222  is fixed on the lifting seat  221 , and the other side of the dustproof belt  222  passes through the lifting seat  221 , that is, the dustproof belt  222  is limited by the lifting seat  221  to prevent from being recessed under a slight external force. For example, the dustproof belt  222  may be fixed on the lifting seat  221  by a fastener. 
     Certainly, in other embodiments, the lifting seat  221  may also be a square hollow structure. The lifting seat  221  is provided with the first through hole  2215  at a top thereof and the second through hole  2216  at a bottom thereof. After passing around the upper rolling shaft  223 , the dustproof belt  222  sequentially passes through the first through hole  2215  and the second through hole  2216 , and then passes around the lower rolling shaft  224 . One side of the lifting seat  221  is fixed on the lifting block  213 , and the opposite side of the lifting seat  221  faces the sliding groove  110 . The mounting portion is located on the opposite side. 
     The lifting platform  230  is fixed on the mounting portion and is located outside the housing  100 . The lifting platform  230  moves along with the movement of the lifting seat  221 . A guide rail can also be formed on the other side wall of the housing  100  opposite to the sliding groove  110 , and the other side of the lifting platform  230  matches with the guide rail. The guide rail has a certain guiding effect on the lifting platform  230  to prevent the lifting platform  230  from shaking during the lifting process. 
     The lifting mechanism  200  further includes a mounting block  240 , which is disposed on the lifting seat  221 . The second side plate  2214  is provided with a via hole  2217 . A tank chain  250  is mounted on the mounting block  240 . One end of the tank chain  250  is fixed on the housing  100  and the other end of the tank chain  250  is fixed on the mounting block  240 . Moreover, the structure of the lifting seat  221  and the mounting block  240  is utilized, so that the wire passing requirement of the cable is met, and the influence on the movement of parts is avoided. Therefore, one end of the tank chain  250  is lifted along with the lifting of the lifting block  213 . A circuit board of the lifting platform  230  is led out by a cable, and one end of the cable passes through the via hole  2217  and turns into the tank chain  250 . The addition of the tank chain  250  can ensure that the bending radius of the cable is not too small, which reduces the fatigue strength and prolongs the service life. In addition, the structure of the lifting seat  221  and the mounting block  240  is utilized, so that the wire passing requirement of the cable is realized without affecting the movement of components. 
     The dustproof assembly also includes a travel switch trigger piece, an upper photoelectric switch  262 , and a lower photoelectric switch  263 . The travel switch trigger piece is disposed on the lifting block  213 , the upper photoelectric switch  262  is disposed on the support frame  216 , and the lower photoelectric switch  263  is disposed on the support frame  216  and is located below the upper photoelectric switch  262 . The upper photoelectric switch  262  is used for the upper positioning, and the lower photoelectric switch  263  is used for the lower positioning. 
     When the lifting block  213  performs the lifting movement, the travel switch trigger piece may shield the upper photoelectric switch  262  or the lower photoelectric switch  263 . At this time, a position feedback signal will be generated, so that the controller can send a command of stopping or reversing to the motor. 
     The dustproof assembly  220  further includes a tightness-adjusting member  225 , which is configured to adjust the tightness of the dustproof belt  222 . The tightness of the dustproof belt  222  can be adjusted by the tightness-adjusting member  225 , so that the dustproof belt  222  can be tightened or loosened. Therefore, it is achieved that in the lifting process of the lifting platform  230 , the sliding groove  110  is in a state of being completely shielded by the dustproof belt  222 . Specifically, the tightness-adjusting member  225  may be a tightness-adjusting nut, and the tightness of the dustproof belt  222  can be adjusted by screwing the tightness-adjusting nut. 
     Before starting treatment, an operator is generally in a standing state, and the heating tank is expected to be higher at this moment to prevent the operator from bending or squatting; during treatment, a patient is generally lying down, at this time, the height of the heating tank is expected to be less than the height of a sickbed, so that the treatment liquid in the bladder can be guided through the connecting pipeline to flow back into the heating tank more smoothly under the action of gravity and siphon. Therefore, the driving shaft  212  can be driven by the first driving source  211  to operate, thereby allowing the lifting block  213  to move up or down along the lifting direction, which drives the lifting platform  230  to move up or down, so that the heating tank carried on the lifting platform  230  can perform the lifting movement. Since the lifting platform  230  is fixed on the mounting portion of the mounting base  240 , the mounting portion is exposed to the housing  100  through the sliding groove  110  on the housing  100 , and since the other end of the dustproof belt  222  is fixed on the lifting seat  221  after passing around the upper rolling shaft  223 , passing through the lifting seat  221 , and passing around the lower rolling shaft  224 , the dustproof belt  222  can always abut against the inner side wall of the housing  100 . Therefore, the dustproof belt  222  can always cover the sliding groove  110  in the lifting process, which effectively prevents sundries or dust from entering the interior of the housing  100 . Certainly, in other embodiments, the lifting mechanism and the dustproof assembly can be omitted, and the heating tank can be directly fixed on the housing. 
     Referring to  FIG. 1  and  FIG. 2  again, the electromagnetic induction heating device is disposed on the housing  100 . Specifically, the electromagnetic induction heating device is indirectly disposed on the housing  100  through the lifting platform  230 . For example, the lifting platform  230  is hollow and is provided with a positioning hole  231 . The electromagnetic induction heating device is located in the lifting platform  230 . Certainly, in other embodiments, when the lifting mechanism and the dustproof assembly are omitted, the electromagnetic induction heating device may also be directly disposed on the housing  100 . 
     The electromagnetic induction heating device includes a tray and an electromagnetic induction coil, which is disposed on one side of the tray and is used to heat the heating tank capable of being carried on the tray. Specifically, the tray has a bearing surface and a back surface provided to face away from the bearing surface. The bearing surface of the tray faces the positioning hole to be exposed to the lifting platform  230 . The electromagnetic induction coil is disposed on one side of the back surface of the tray, and is located in the hollow lifting platform  230 , and is led out of the lifting platform  230  by a cable. Specifically, the tray may be made of an insulating and heat-resistant material. For example, the tray can be made of a non-metallic material, such as nylon. 
     The electromagnetic induction heating device also includes a weighing sensor, the weighing sensor is disposed below the tray and is configured to measure a weight of the medicinal solution in the heating tank carried on the tray. Both the weighing sensor and the electromagnetic induction coil are electrically coupled to the controller, and the weighing sensor controls the electromagnetic induction coil to be powered on or off through the controller. Certainly, in other embodiments, the weighing sensor may also be omitted, and the electromagnetic induction coil may be controlled to be powered on or off by the touch display. For example, the touch display is provided with physical or virtual switch buttons. When the total amount of medicinal solution in the heating tank meets the requirements, the electromagnetic induction coil can be controlled to be powered on or off by the switch buttons. 
     Referring to  FIG. 6  to  FIG. 8 , the circulation pipeline for hyperthermic perfusion  400  includes a heating tank  410 , a liquid inlet pipeline  101 , a liquid outlet pipeline  102 , a circulation pump  420 , a cavity inlet pipeline  105 , and a cavity outlet pipeline  106  to form a circulation pipeline system, which is connected to a urinary catheter  11 ′ placed in the bladder  10 ′. Specifically, in the present embodiment, the circulation pipeline for hyperthermic perfusion  400  may further include a pre-filling pipeline  103  to realize that the air in the pipeline system can be exhausted before treatment to avoid causing inflammation. Certainly, in other embodiments, the pre-filling pipeline  103  may be omitted. 
     Referring to  FIG. 9  to  FIG. 11  together, the heating tank  410  is hollow to form a liquid storage cavity  410   a , which is configured to store the medicinal solution. The heating tank  410  is carried on the tray, and the electromagnetic induction coil is used to heat the heating tank  410  to indirectly heat the medicinal solution stored in the liquid storage cavity  410 a. One end of the liquid inlet pipeline  101  is in communication with the liquid storage cavity  410   a , and the other end of the liquid inlet pipeline  101  is configured to be in communication with a medicinal solution bag  600 ′ (or a medicinal solution bottle, a medicinal solution tank, etc.). One end of the liquid outlet pipeline  102  is in communication with the liquid storage cavity  410   a , and the other end of the liquid outlet pipeline  102  is in communication with one end of the pre-filling pipeline  103  and one end of the cavity inlet pipeline  105 . The pre-filling pipeline  103  and the cavity inlet pipeline  105  are arranged in parallel. For example, a pipette  107  may be connected in series to one end of the liquid outlet pipeline  102 , the pipette  107  extends into the liquid storage cavity  410   a , and one end of the pipette  107  is proximate to a bottom of the heating tank  410  to ensure that the medicinal solution in the heating tank  410  can be smoothly extracted into the liquid outlet pipeline  102 . 
     The circulation pump  420  is connected in series to the liquid outlet pipeline  102 , and is configured to extract the medicinal solution in the liquid storage cavity  410 a. Specifically, the circulation pump  420  includes a roller pump  421  and two pump pipe joints  422 . The two pump pipe joints  422  are respectively connected to two opposite ends of the roller pump  421 , and are configured to connect the roller pump  421  in series to the liquid outlet pipeline  102 . The roller pump  421  is configured to adjust a speed of extracting liquid from the heating tank  410 . 
     One end of the pre-filling pipeline  103  is in communication with the other end of the liquid outlet pipeline  102 , and the other end of the pre-filling pipeline  103  is in communication with one end of the liquid return pipeline  104 . The pre-filling pipeline  103  is connected in parallel with both the cavity inlet pipeline  105  and the cavity outlet pipeline  106 . A pre-filling valve  1031  is also connected in series to the pre-filling pipeline  103  and is configured to control opening and closing of the pre-filling pipeline  103 . One end of the liquid return pipeline  104  is in communication with the other end of the pre-filling pipeline  103  and the other end of the cavity outlet pipeline  106 , and the other end of the liquid return pipeline  104  is in communication with the liquid storage cavity  410   a.  The liquid return pipeline  104  is capable of allowing the medicinal solution in the bladder  10 ′ discharged through the cavity outlet pipeline  106  to flow back to the heating tank  410 . For example, the liquid return pipeline  104 , the pre-filling pipeline  103 , and the cavity outlet pipeline  106  may be connected together through a T-pipe. 
     One end of the cavity inlet pipeline  105  is in communication with the other end of the liquid outlet pipeline  102 , and the other end of the cavity inlet pipeline  105  is configured to be in communication with the body cavity (the bladder  10 ′ in the present embodiment). The cavity inlet pipeline  105  is capable of introducing the medicinal solution into the bladder  10 ′. Specifically, a cavity inlet valve  1051  may be connected in series to the cavity inlet pipeline  105  to control the opening and closing of the cavity inlet pipeline  105 . A cavity inlet conical head  1052  can also be provided on the other end of the cavity inlet pipeline  105  to facilitate cooperation with the urinary catheter  11 ′. Optionally, a protection cap  1053  can also be sleeved on the cavity inlet conical head  1052 , and is configured to protect the cavity inlet conical head  1052  when not in use, thereby preventing foreign dust or debris from entering the cavity inlet pipeline  105 . 
     One end of the cavity outlet pipeline  106  is configured to be in communication with the body cavity (the bladder  10 ′ in the present embodiment), and the other end of the cavity outlet pipeline  106  is in communication with the liquid return pipeline  104 . The pre-filling pipeline  103  is connected in parallel with the cavity inlet pipeline  105  and the cavity outlet pipeline  106 . The medicinal solution in the bladder  10 ′ can be discharged by the cavity outlet pipeline  106 , and flowed back to the heating tank  410  through the liquid return pipeline  104 . Specifically, a cavity outlet valve  1061  may be connected in series to the cavity outlet pipeline  106 , and is configured to control opening and closing of the cavity outlet pipeline  106 . A cavity outlet conical head  1062  can also be provided on one end of the cavity outlet pipeline  106  to facilitate cooperation with the urinary catheter  11 ′. Optionally, a protection cap  1063  can also be sleeved on the cavity outlet conical head  1062 , and is configured to protect the cavity outlet conical head  1062  when not in use, thereby preventing foreign dust or debris from entering the cavity outlet pipeline  106 . 
     The heating tank  410  is a non-deformable tank. The heating tank  410  includes a tank body  411  and a cover body  412 . The tank body  411  is hollow, and one end of the tank body  411  is opened to form an open end. The cover body  412  is disposed on the open end of the tank body  411 . The cover body  412  and the tank body  411  together form the liquid storage cavity  410   a  that is configured to store liquid. During use, the tank body  411  is configured to be placed on the electromagnetic induction heating device, and the electromagnetic induction heating device is configured to heat the tank body  410  to indirectly heat the liquid in the liquid storage cavity  410   a , so that a non-direct contact heating method is achieved, the medicinal solution can be prevented from being polluted, thereby meeting the aseptic requirements. 
     Specifically, in the present embodiment, the tank body  411  includes a tank shell  4111  and a base  4112 . The base  4112  is disposed on the bottom of the tank body  411 . The tank shell  4111  is made of plastic materials, and the base  4112  is made of metal materials. The base  4112  and the tank shell  4111  are integrally formed by an injection molding. Therefore, the entire heating tank  410  has a low manufacturing cost and a simple manufacturing process, and is convenient to use as a disposable product. When an electromagnetic induction coil is energized, only the bottom of the heating tank  410  is heated, and the liquid in the heating tank  410  is uniformly heated by utilizing the natural convection action of the liquid in the heating tank  410 . For example, the base  4112  may be made of medical grade  304  stainless steel. 
     Certainly, in other embodiments, the tank body  411  has the bottom, which is away from the open end. Only the bottom of the tank body  411  is made of metal materials, and the rest of the tank body  411  is made of plastic materials. Alternatively, the tank body  411  may be integrally made of metal materials. Therefore, when the electromagnetic induction coil is energized to heat the heating tank  410 , the liquid in the heating tank  410  is heated indirectly. 
     Specifically, in the present embodiment, the heating tank  410  further includes an air filter  413  and a sealing cap  414 . A matching joint  415  is formed on the cover body  412 , and the air filter  413  is in communication with the liquid storage cavity  410   a  through the matching joint  415 . The sealing cap  414  is capable of sealing the air filter  413 . The air filter  413  is mainly used to prevent bacteria or particles in the air from directly entering the liquid storage cavity  410   a  to cause the contamination of the medical solution when the air pressure in the tank body  411  is in communication with the atmospheric pressure. Specifically, the air filter  413  includes a multilayer air filter element for filtering external air to prevent the bacteria carried in the air from entering the liquid storage cavity  410 a. For example, the air filter  413  includes a casing made of ABS and AS materials, and a filter membrane made of PP and PTFE materials. A filtration rate of  0 . 5  micron particles in the air with the air filter  413  is greater than 90%. 
     Specifically, the air filter  413  is connected to the matching joint  415  by a threaded engagement. The air filter  413  is provided with a through-hole. The air filter element is located in the through-hole. The sealing cap  414  is rotatably disposed on the air filter  413  and can seal the through-hole. The sealing cap  414  is mainly used to adjust the pressure in the liquid storage cavity  410 a. Since the tank body  411  is made of a non-deformable material, when the volume of the medicinal solution in the tank body  411  is changed, the pressure in the tank body  411  is changed. For example, when the medicinal solution is injected into the heating tank  410 , the pressure in the tank body  411  increases with the increase of the medicinal solution, which may eventually cause the pressure in the tank body  411  to be equal to the pressure for injecting the medicinal solution, so that no more medicinal solution can be injected. Alternatively, when the tank body  411  is fully loaded, a negative pressure may be generated in the liquid storage cavity  410   a  after the medicinal solution in the liquid storage cavity  410   a  is extracted. At this time, the medicinal solution in the bladder  10 ′ can be sucked out by adjusting the negative pressure. 
     Specifically, in the present embodiment, the heating tank  410  further includes a first temperature measuring assembly  416 , which is used to accurately measure the temperature of the liquid in the liquid storage cavity  410   a  to monitor the temperature of the liquid in real time. The first temperature measuring assembly  416  includes a first temperature sensor and a first hollow pipe. The first temperature sensor has a first probe end extending into the first hollow pipe and located on an end of the first hollow pipe. One end of the first hollow pipe extends into the liquid storage cavity  410   a  and is disposed proximate to the bottom of the tank body  411 . Therefore, the first temperature measuring assembly  416  can always be in contact with the liquid to ensure that the actual temperature of the liquid is measured, rather than the temperature of the air leaving the liquid level. However, there is a certain distance between the end of the first temperature measuring assembly  416  and the bottom, so that the phenomenon that the first temperature measuring assembly  416  generates heat or is interfered by the electromagnetic induction heating device to cause inaccurate measurement is avoided. 
     The heating tank  410  further includes a stirring impeller  417 , which is located in the liquid storage cavity  410   a  and below the liquid return pipeline  104 , and is capable of rotating under the action of the liquid flowing back to the liquid storage cavity  410   a  through the liquid return pipeline  104 . Specifically, the stirring impeller  417  is disposed on a side of the cover body  412  facing the tank body  411  by a support frame  418 . The stirring impeller  417  includes a stirring blade  4171  and a rotating shaft  4172 . Both ends of the rotating shaft  4172  are rotatably disposed on the support frame  418 , and the stirring blade  4171  is fixed on the rotating shaft  4172 . Certainly, in other embodiments, the rotating shaft  4172  may also be fixed on the support frame  418 , and the stirring blade  4171  may rotate relative to the rotating shaft  4172 . 
     When the liquid storage cavity  410   a  is filled with liquid, the electromagnetic induction heating device indirectly heats the liquid through the tank body of the heating tank  410 . Because the base  4112  of the tank body  411  or the bottom of the tank body  411  is made of stainless steel, the heat is transferred to the liquid from the bottom of the tank body  411 . The density of the liquid decreases after the liquid is heated, the liquid will naturally float upwards, while the liquid with a low temperature above will sink, thereby resulting in a natural convection process. In this process, the stirring impeller  417  is also rotated, thereby playing a role of stirring. 
     Referring to  FIG. 1 ,  FIG. 6 , and  FIG. 7  again, the circulation pipeline for hyperthermic perfusion  400  further includes a pressure measuring assembly  430 , which is connected in series to the liquid outlet pipeline  102  and is located behind a station of the circulation pump  420 . The pressure measuring assembly  430  is configured to measure a pressure in the liquid outlet pipeline  102  behind the station of the circulation pump  420 , so that the pressure in the liquid outlet pipeline  102  can be monitored, which may avoid the damage to the bladder  10 ′ caused by the excessive pressure, or avoid that the medicinal solution cannot enter the bladder  10 ′ due to the too little pressure. 
     Specifically, the pressure measuring assembly  430  includes a pressure measuring extension pipe  431 , a pressure measuring valve  432 , and a pressure measuring protection cap  433 . The pressure measuring extension pipe  431  is connected in series to the liquid outlet pipeline  102  and is located behind the station of the circulation pump  420 . The pressure measuring valve  432  is configured to control opening and closing of the pressure measuring extension pipe  431 , and the pressure measuring protection cap  433  is sleeved on one end of the pressure measuring extension pipe  431 . The pressure of the medicinal solution flowing out of the circulation pump  420  in the liquid outlet pipeline  102  can be monitored in real time by externally connecting the pressure measuring extension pipe  431  to the pressure measuring sensor. 
     One end of the liquid inlet pipeline  101 , which is configured to be in communication with the medicinal solution bag, is provided with a contact pin  108 . The contact pin  108  is used to be inserted into the medicinal solution bag to smoothly introduce the medicinal solution in the medicinal solution bag into the liquid inlet pipeline  101 . Optionally, a protection cover  109  can also be sleeved on the contact pin  108  to cover the contact pin  180 , which not only prevents the contact pin  108  from accidentally damaging the operator, but also prevents external debris and dust from entering the liquid inlet pipeline  101  through the contact pin. 
     Referring to  FIG. 12  to  FIG. 14 , the circulation pipeline for hyperthermic perfusion  400  further includes a two-way valve  440 . The two-way valve  440  is connected in series to the liquid inlet pipeline  101  and is configured to control opening and closing of the liquid inlet pipeline  101 . Specifically, the two-way valve  440  can realize the opening and closing of the liquid inlet pipeline  101  by an automatic control manner. Referring to  FIG. 15  to  FIG. 18 , the two-way valve  440  includes a valve main body  441  including a valve core  4411  and a valve body  4412 . The valve core  4411  is provided with a liquid through hole  111 . At least one end of the valve body  4412  is opened and an interior of the valve body  4412  is hollow to form a receiving cavity. A first liquid inlet channel  4413  and a first liquid outlet channel  4414  which are in communication with the receiving cavity are formed on a side wall of the valve body  4412 . One end of the valve core  4411  extends into the receiving cavity, and is rotatable relative to the valve body  4412 , so that the liquid through hole  111  can be or cannot be in communication with the first liquid inlet channel  4413  and the first liquid outlet channel  4414 . 
     The valve core  4411  is also provided with a blind hole  112 , and the liquid through hole  111  and the blind hole  112  are not in communication with each other. For example, the liquid through hole  111  extends in a radial direction of the valve core  4411 , and the blind hole  112  extends in an axial direction of the valve core  4411 . A barrier wall is provided between the liquid through hole  111  and the blind hole  112  to prevent the liquid through hole  111  from being in communication with the blind hole  112 , so that liquid leakage is avoided. The valve core  4411  has a substantially cylindrical shape, and the receiving cavity is substantially a circular hole, which may facilitate the rotation of the valve core  4411  in the receiving cavity. Certainly, in other embodiments, the liquid through hole  111  may not only be limited to extend in the radial direction, but may also be a curved through hole or the like, for example, as long as the liquid through hole  111  can allow the liquid to circulate and is not in communication with the blind hole  112 . 
     When the liquid through hole  111  is opposite to the first liquid inlet channel  4413  and the first liquid outlet channel  4414 , the two-way valve  440  is in a communication state. When the liquid through hole  111  is staggered from the first liquid inlet channel  4413  and the first liquid outlet channel  4414 , the two-way valve  440  is in a non-communication (i.e. disconnected) state. The valve core  4411  and the valve body  4412  are in an interference fit to prevent leakage. 
     Specifically, in the present embodiment, an outer side wall of the end of the valve core  4411  extending into the receiving cavity wall is recessed to form a positioning groove, and an inner side wall of the receiving cavity protrudes to form a positioning convex ring matched with the positioning groove. Therefore, the positions of the valve core  4411  and the valve body  4412  can be positioned by the matching of the positioning groove with the positioning convex ring, which may prevent the valve core  4411  from excessively extending into the valve body  4412 . 
     Specifically, in the present embodiment, the other end of the valve core  4411  extends out of the receiving cavity, and the other end of the valve core  4411  protrudes to form an operation handle  4415 . The operation handle  4415  can be operated manually to rotate the valve core  4411  relative to the valve body  4412 , which prevents a situation where the valve core  4411  cannot be rotated due to the failure of the automatic control method. 
     Referring to  FIGS. 12 to 14  again, the two-way valve  440  further includes a driving mechanism  442  and a mounting mechanism  443 . The mounting mechanism  443  is used to mount the valve body  441 . The driving mechanism  442  can automatically drive the valve core  4411  to rotate relative to the valve body  4412 , thereby realizing the opening and closing of the liquid inlet pipeline  101 . The driving mechanism  442  includes a second driving source  4421  and a driving shaft  4422 . The second driving source  4421  is used to drive the driving shaft  4422  to rotate. One end of the driving shaft  4422  extends into the blind hole  112 , and the driving shaft  4422  can drive the valve core  4411  to rotate relative to the valve body  4412 . Specifically, the second driving source  4421  may be a motor. The driving shaft  4422  can be an in-line shaft, and the blind hole  112  can be an in-line hole, so that it can be ensured that the rotation of the driving shaft  4422  can drive the valve core  4411  to rotate without relative sliding. Certainly, in other embodiments, the driving shaft  4422  and the blind hole  112  may also be other shapes, as long as the purpose that the rotation of the valve shaft  4422  can drive the valve core  4411  to rotate without relative sliding can be achieved. The second driving source  4421  is electrically coupled to the controller. The controller controls the second driving source  4421  to drive the driving shaft  4422  to rotate for driving the valve core  4411  to rotate relative to the valve body  4412 . 
     The mounting mechanism  443  includes a mounting base  310 , a supporting plate  320 , a spring  330 , a first mounting plate  340 , a guide post  350 , and a second mounting plate  370 . Referring to FIG. 
       19  and  FIG. 20 , the mounting base  310  is provided with a through hole  311  that penetrates two opposite ends of the mounting base  310 . The through hole  311  is provided with a guide groove  312 , a communicating groove  313 , and a limiting groove  314  at an inner wall thereof. The guide groove  312  extends along an axial direction of the mounting base  310  and penetrates at least one end surface of the mounting base  310 . The communicating groove  313  is in communication with the guide groove  312  and the limiting groove  314 . 
     For example, in the present embodiment, the guide groove  312  penetrates the opposite end surfaces of the mounting base  310 , so that the guide groove  312  is a through groove, and one end of the valve body  4412  can penetrate the mounting base  310  through the guide groove  312 . The communicating groove  313  penetrates one of the end surfaces of the mounting base  310 , and the one of the end surfaces is the end surface of the mounting base  310  facing the supporting plate  320 . The limiting groove  314  also penetrates one of the end surfaces of the mounting base  310 , and the one of the end surfaces is the end surface of the mounting base  310  facing the supporting plate  320 . The limiting groove  314  does not penetrate the end surface of the mounting base  310  facing the valve core  4411  to play a role of limiting. 
     Certainly, in other embodiments, the guide groove  312  may penetrate only one of the end surfaces of the mounting base  310 , and the one of the end surfaces is the end surface facing the valve core  4411 . At this time, neither the communicating groove  313  nor the limiting groove  314  penetrates the end surface of the mounting base  310 . 
     An outer side wall of one end of the valve body  4412  protrudes to form a positioning block  121  extending along an axial direction of the valve body  4412 . The positioning block  121  can extend from the guide groove  312  into the mounting base  310  and move into the limiting groove  314  through the communicating groove  313 . Specifically, in the present embodiment, the number of the positioning blocks  121  is two, and the two positioning blocks  121  are oppositely disposed on the outer side wall of the valve body  4412  at intervals. Correspondingly, the number of the guide grooves  312 , the communicating grooves  313 , and the limiting grooves  314  is also two, and one positioning block  121  corresponds to one guide groove  312 , one communicating groove  313 , and one limiting groove  314 . For example, the two positioning blocks  121  are separated by 180 degrees. Similarly, the two guide grooves  312  are also separated by 180 degrees, the two communicating grooves  313  are also separated by  180  degrees, the two limiting grooves  314  are also separated by  180  degrees. The guide groove  312  and the limiting groove  314  are separated by 45 degrees. Therefore, during assembling, the valve body  4412  is inserted into the guide groove  312  of the mounting base  310  through the positioning block  121 , and the positioning block  121  matches with the guide groove  312  to play a role of guiding. 
     The two positioning blocks  121  are different in size, so that it can effectively play a fool-proof role and avoid errors during assembly. An outer side wall of the positioning block  121  facing away from the valve body  4412  is a tapered surface, so that it can better match with the guide groove  312  to better play a role of guiding. During assembly, the positioning block  121  is inserted into the mounting base  310  through the guide groove  312 , and then moves along the communicating groove  313  into the limiting groove  314 , and is restricted in the limiting groove  314 . The positioning block  121  plays a role of a snap-action. 
     Specifically, in the present embodiment, the valve body  4412  is formed with an antiskid texture  122  on the outer side wall thereof, so that a friction between the hand and the valve body  4412  can be increased during assembly. The outer side wall of the valve body  4412  protrudes to form a positioning baffle  123 . Therefore, during assembly, the positioning baffle  123  is mainly used to position the hand. In addition, the valve body  4412  needs to be pressed downwards during assembly, so that the positioning baffle  123  can provide a pressing stress surface, and the assembly is convenient. 
     The supporting plate  320  is located between the mounting base  310  and the spring  330 . One end of the driving shaft  4422  passes through the supporting plate  320  and the through hole  311  of the mounting base  310 , and extends into the blind hole  112 . The spring  330  is sleeved on the driving shaft  4422 , and one end of the spring  330  abuts against the supporting plate  320 , and the other end of the spring  330  abuts against the second driving source  4421 . 
     The first mounting plate  340  is provided with a first through hole that penetrates two opposite sides of the first mounting plate  340 , and one end of the driving shaft  4422  and one end of the spring  330  pass through the first through hole. The second driving source  4421  is mounted on the first mounting plate  340 , and the supporting plate  320  is located between the first mounting plate  340  and the mounting base  310 . The first through hole may be a stepped hole, and the supporting plate  320  can move reciprocally in the stepped hole under the action of an elastic force of the spring  330 . 
     The supporting plate  320  is provided with at least two first guide holes. A second guide hole is formed on one side of the first mounting plate  340  facing the supporting plate  320 . The guide post  350  is provided in and sequentially passes through the first guide holes and the second guide hole. 
     The guide post  350  is provided to ensure that the supporting plate  320  moves reciprocally along the axial direction to prevent the supporting plate  320 , the mounting base  310 , the valve body  4412 , and the valve core  4411  from shaking. For example, the number of the first guide holes may be four, and the first guide holes are respectively distributed at four corners of the supporting plate  320 . Correspondingly, the number of the guide posts  350  and the second guide holes are four. The guide posts  350  and the second guide holes are matched with the first guide holes. 
     The housing  100  is provided with a second through hole that penetrates two opposite sides of the housing  100 . The housing  100  is located between the mounting base  310  and the first mounting plate  340 , and the first mounting plate  340  is fixed on the housing  100 . Therefore, the whole management system can have a fixed point during use to prevent the pipeline system from shaking. The second through hole may be a stepped hole. Correspondingly, the mounting base  310  may be a circular boss structure matched with the stepped hole. 
     The second mounting plate  370  and the first mounting plate  340  are respectively located at two opposite ends of the second driving source  4421 , and the two-way valve  440  further includes an indexing positioner  444  and two photoelectric switches  445  disposed at intervals. The two photoelectric switches  445  are mounted on the second mounting plate  370 . The indexing positioner  444  is provided with three positioning holes and is disposed at the other end of the driving shaft  4422 . The indexing positioner  444  rotates relative to the photoelectric switch along with the rotation of the driving shaft  4422 . The photoelectric switch  445  is electrically coupled to the controller, so that the actual position of the two-way valve  440  can be determined by the two photoelectric switches  445  and can be fed back to the controller in real time. 
     Referring to  FIG. 21  to  FIG. 23 , specifically, in the present embodiment, the three positioning holes are a first positioning hole  446 , a second positioning hole  447 , and a third positioning hole  448 , respectively. The first positioning hole  446  is separated from the third positioning hole  448  by 180 degrees, the first positioning hole  446  is separated from the second positioning hole  447  by 45 degrees, and the second positioning hole  447  is separated from the third positioning hole  448  by 135 degrees. The two photoelectric switches  445  are separated by 135 degrees. When any positioning hole is located directly below the photoelectric switch  445 , the photoelectric switch  445  outputs  1 ; otherwise, the photoelectric switch  445  outputs  0 . 
     One end of the valve core  4411  extends into the receiving cavity of the valve body  4412  until the positioning groove matches with the positioning convex ring. At this time, the liquid through hole  111  is not in communication with the first liquid inlet channel  4413  and the first liquid outlet channel  4415 . Then, the valve body  4412  is pressed, the valve body  4412  presses the supporting plate  320 , the supporting plate  320  presses the spring  330  to compress the spring  330 . One end of the valve body  4412  extends into the through hole  311 , and the positioning block  121  moves in the guide groove  312 . At this time, the two-way valve  440  is in the initial position, which corresponds to the state shown in  FIG. 10 , where the second positioning hole  447  and the third positioning hole  448  are located directly below the photoelectric switches  445 . The states output by the two photoelectric switches  445  are “11”. 
     When the communicating groove  313  is reached, the valve body  4412  is rotated clockwise by  45  degrees. At this time, the positioning block  121  moves from the guide groove  312  into the limiting groove  314  through the communicating groove  313 , and then the valve body  4412  is released, the valve body  4412  and the supporting plate  320  are limited in the limiting groove  314  by a restoring force of the spring  330 . At this time, only the first positioning hole  446  is located directly below the photoelectric switch  445 , and the states output by the two photoelectric switches  445  are “10”. 
     When the second drive source  4421  drives the valve core  4411  to continue to rotate clockwise by 90 degrees, the second positioning hole  447  is located directly below the photoelectric switch  445 , and the states output by the two photoelectric switches  445  are “01”. Therefore, the actual position of the two-way valve  440  can be determined by the two photoelectric switches  445  and can be fed back to the controller in real time. 
     Referring to  FIG. 7 ,  FIG. 24 , and  FIG. 25 , the circulation pipeline for hyperthermic perfusion  400  further includes a dosing joint  450 , which is connected in series to the liquid inlet pipeline  101 . Chemotherapy drugs and the like can be injected into the liquid inlet pipeline  101  through the dosing joint  450 . The dosing joint  450  includes a dosing pipe body  510 , a handle  520 , and a protection flap  530 . An infusion channel  510   a  in communication with the liquid inlet pipeline  101  is formed inside the dosing pipe body  510 . A dosing hole  511  in communication with the infusion channel  510   a  is formed on a side wall of the dosing pipe body  510 . The dosing pipe body  510  is provided with a dosing soft plug  540  for sealing the dosing hole  511  to prevent air or other dust from entering the pipeline system. Specifically, the dosing soft plug  540  may be a silicone plug. Certainly, in other embodiments, the dosing soft plug  540  may also be made of other soft materials, as long as the dosing soft plug  540  is capable of sealing the dosing hole  511  and being inserted by a needle tip of a syringe. 
     The handle  520  is disposed on an outer side wall of the dosing pipe body  510  and is spaced apart from the dosing hole  511 . The protection flap  530  is disposed on the outer side wall of the dosing pipe body  510  and is located between the dosing hole  511  and the handle  520  to form a protection wall. Therefore, when one hand holds the handle  520  and the other hand holds the syringe and the needle tip of the syringe is inserted into the dosing soft plug  540 , the protection flap  530  forms a protection wall between the hand and the needle tip, which may effectively prevent the needle tip from hurting the hands due to careless operation. 
     Referring to  FIG. 7 ,  FIG. 26 , and  FIG. 27 , the circulation pipeline for hyperthermic perfusion  400  further includes a cavity inlet flow indicator  460 , which is connected in series to the liquid outlet pipeline  102 . For example, in the present embodiment, the cavity inlet flow indicator  460  is located behind the station of the pressure measuring assembly  430 . The cavity inlet flow indicator  460  may be more beneficial for observing a flow status of the liquid in the pipeline system. 
     Specifically, the cavity inlet flow indicator  460  includes a seating  610 , an impeller  620 , a transparent cover body  630 , and a light-shielding upper cover  640 . The seating  610  is formed with an impeller cavity  610   a  that is in communication with the liquid outlet pipeline  102 . The impeller  620  is rotatably disposed on the seating  610  through a rotating shaft  650  and is located in the impeller cavity  610   a.  The transparent cover body  630  is disposed on the seating  610  to seal the impeller cavity  610   a . The light-shielding upper cover  640  is coverably disposed on the seating  610 , and is capable of covering the transparent cover body  630 . 
     The seating  610  is made of a light-shielding material, and the transparent cover body  630  may be made of a transparent material, such as transparent plastic or transparent glass. When the liquid enters the impeller cavity  610   a , the impeller  620  is washed due to the continuity of the liquid. The impeller  620  may rotate under the action of the flowing liquid, and whether the liquid is in a flowing state can be known by observing whether the impeller  620  rotates through the transparent cover  630 . 
     The impeller  620  is eccentrically disposed with respect to the impeller cavity  610   a  to accommodate a lower flow velocity. For example, in the case of that a flow indicator is applied to a bladder  10 ′ circulation hyperthermic perfusion device, during the treatment, the flow velocity in the pipeline system is generally between 50 ml/min and 200 ml/min, in most cases, the flow velocity is lower than 150 ml/min. Such flow velocity is relatively low, thereby requiring increased sensitivity to rotation of the impeller  620 . 
     Referring to  FIG. 8  and  FIG. 28  to  FIG. 29 , the circulation pipeline for hyperthermic perfusion  400  further includes a cavity inlet thermometer  470 . The cavity inlet thermometer  470  is connected in series to the liquid outlet pipeline  102  and is configured to measure the temperature of the liquid flowing in the liquid outlet pipeline  102  in real time and truthfully, so as to monitor the true temperature of the liquid entering the bladder  10 ′. For example, in the present embodiment, the cavity inlet thermometer  470  is located behind the station of the cavity inlet flow indicator  460 . 
     The cavity inlet thermometer  470  includes a first liquid storage housing  710 , a second temperature measuring assembly  720 , a first cavity inlet end cover  730 , and a second cavity inlet end cover  740 . An interior of the first liquid storage housing  710  is hollow to form a first liquid storage cavity  710   a  in communication with the liquid outlet pipeline  102 . The first liquid storage housing  710  includes a first small-diameter end  711  and a first large-diameter end which are oppositely disposed. An inner diameter of the first small-diameter end  711  is less than an inner diameter of the first large-diameter end  712 . 
     The second temperature measuring assembly  720  includes a second hollow pipe  721  and a second temperature sensor. The second temperature sensor has a second probe end  722  extending into the second hollow pipe  721  and located on an end of the second hollow pipe  721 . The first cavity inlet end cover  730  covers the first large-diameter end  712  of the first liquid storage housing  710 , and the second cavity inlet end cover  740  is disposed on the first small-diameter end  711  of the first liquid storage housing  710 . The second hollow pipe  721  extends into the first liquid storage cavity  710   a  from the first cavity inlet end cover  730  and is adjacent to the first liquid inlet through hole  741  on the second cavity inlet end cover  740 . 
     If the second probe end  722  of the second temperature sensor is too close to a side wall of the first liquid storage housing  710  or directly adheres to the side wall of the first liquid storage housing  710 , the measured temperature will be 1° C. to 2° C. lower than the actual temperature of the liquid because of the inevitable heat dissipation of the first liquid storage housing  710 . If the second probe end  722  of the second temperature sensor is located in the middle of the first liquid storage cavity  710   a,  since there is a dead water zone or the flow velocity less than the actual flow velocity of the liquid in the pipeline, the measured temperature will also be 1° C. lower than the actual temperature of the liquid. Therefore, in the present embodiment, the second probe end  722  is disposed adjacent to the first liquid inlet through hole, but is not in direct contact with the first liquid storage housing  710 . 
     Referring to  FIG. 8 , the circulation pipeline for hyperthermic perfusion  400  further includes a cavity outlet thermometer  470 ′, which is connected in series to the liquid return pipeline  104  and is configured to measure the temperature of the liquid flowing from the bladder  10 ′ through the cavity outlet pipeline  106  in real time and truthfully. Specifically, the structure of the cavity outlet thermometer  470 ′ is substantially the same as the structure of the cavity inlet thermometer  470 . 
     The cavity outlet thermometer  470 ′ includes a second liquid storage housing, a third temperature measuring assembly, a first cavity outlet end cover, and a second cavity outlet end cover. An interior of the second liquid storage housing is hollow to form a second liquid storage cavity in communication with the liquid return pipeline. The second liquid storage housing includes a second small-diameter end and a second large-diameter end which are oppositely disposed. An inner diameter of the second small-diameter end is less than an inner diameter of the second large-diameter end. 
     The third temperature measuring assembly includes a third hollow pipe and a third temperature sensor. The third temperature sensor has a third probe end extending into the third hollow pipe and located at an end of the third hollow pipe. The first cavity outlet end cover covers the second large-diameter end of the second liquid storage housing, and the second cavity outlet end cover is disposed on the second small-diameter end of the second liquid storage housing. The third hollow pipe extends into the second liquid storage cavity from the first cavity outlet end cover and is adjacent to the second liquid inlet through hole on the second cavity outlet end cover. 
     If the third probe end of the third temperature sensor is too close to the side wall of the second liquid storage housing or directly adheres to the side wall of the second liquid storage housing, the measured temperature will be 1° C. to 2° C. lower than the actual temperature of the liquid because of the inevitable heat dissipation of the second liquid storage housing. If the third probe end of the third temperature sensor is located in the middle of the second liquid storage cavity, since there is a dead water zone or the flow velocity less than the actual flow velocity of the liquid in the pipeline, the measured temperature will also be 1° C. lower than the actual temperature of the liquid. Therefore, in the present embodiment, the third probe end is disposed adjacent to the second liquid inlet through hole, but is not in direct contact with the second liquid storage housing. 
     Referring to  FIG. 7 ,  FIG. 30 , and  FIG. 31 , the circulation pipeline for hyperthermic perfusion  400  further includes a filter  480  connected in series to the liquid return pipeline  104 . For example, the filter  480  is located behind the station of the cavity outlet thermometer  470 ′. The filter  480  can filter the medicinal solution flowing out of the bladder  10 ′ to prevent dropped tissues from damaging other components and parts. 
     Specifically, the filter  480  includes a housing  810 , a filter element  820 , an upper cover  830 , and a lower cover  840 . The housing  810  is formed with a filter element cavity  810   a  that is in communication with the liquid return pipeline  104 . The filter element  820  is received in the filter element cavity  810   a  and is configured to filter the medicinal solution. Specifically, the housing  810  may be hollow cylindrical. The filter element  820  includes a holder  821  and a filter screen  822 , and the filter screen  822  is disposed on the holder  821 . The upper cover  830  is disposed on one end of the housing  810 , and the lower cover  840  is disposed on the other end of the housing  810 . 
     A side wall of one end of the housing  810  protrudes outward to form a positioning step  811 . The holder  821  includes a positioning cylinder  8211  and at least two reinforcing ribs  8212 . The positioning cylinder  8211  abuts against the positioning step  811 . One end of each reinforcing rib  8212  is disposed on the positioning cylinder  8211 . The reinforcing ribs  8212  are distributed at intervals in the radial direction. When the filter element  820  is assembled into the housing  810 , one end of the filter element  820  extends into the filter element cavity  810   a  until the positioning cylinder  8211  abuts against the positioning step  811  to complete the assembly, so that the assembly and disassembly are facilitated. 
     Referring to  FIG. 7 , the circulation pipeline for hyperthermic perfusion  400  further includes a cavity outlet flow indicator  460 ′ that is connected in series to the liquid return pipeline  104 . For example, in the present embodiment, the cavity outlet flow indicator  460 ′ is connected in series behind the station of the filter  480 . The structure of the cavity outlet flow indicator  460 ′ is substantially the same as the structure of the cavity inlet flow indicator  460 . 
     Specifically, the cavity outlet flow indicator  460 ′ includes a seating  610 , an impeller  620 , a transparent cover body  630 , and a light-shielding upper cover  640 . The seating  610  is formed with an impeller cavity  610   a  in communication with the liquid outlet pipeline  104 . The impeller  620  is rotatably disposed on the seating  610  through a rotating shaft and is located within the impeller cavity  610   a.  The transparent cover body  630  is disposed on the seating  610  to seal the impeller cavity  610   a . The light-shielding upper cover 830640 is coverably disposed on the seating  610  and is capable of covering the transparent cover body  630 . 
     The seating  610  is made of a light-shielding material, and the transparent cover body  630  may be made of a transparent material, such as transparent plastic or transparent glass. When the liquid enters the impeller cavity  610   a , the impeller  620  is washed due to the continuity of the liquid. The impeller  620  may rotate under the action of the flowing liquid, and whether the liquid is in a flowing state can be known by observing whether the impeller  620  rotates through the transparent cover  630 . 
     The impeller  620  is eccentrically disposed with respect to the impeller cavity  610   a  to accommodate a lower flow velocity. For example, in the case of that a flow indicator is applied to a bladder  10 ′ circulation hyperthermic perfusion device, during the treatment, the flow velocity in the pipeline system is generally between 50 ml/min and 200 ml/min, in most cases, the flow velocity is lower than 150 ml/min. Such flow velocity is relatively low, thereby requiring increased sensitivity to rotation of the impeller  620 . 
     Referring to  FIG. 7 , the circulation pipeline for hyperthermic perfusion  400  further includes a flow regulating valve  490 , which is connected in series to the liquid return pipeline  104 . For example, in the present embodiment, the flow regulating valve  490  is located behind the station of the cavity outlet flow indicator, and is configured to regulate a flow velocity of the medicinal solution in the liquid return pipeline  104 . 
     Specifically, the liquid inlet pipeline  101 , the liquid outlet pipeline  102 , the pre-filling pipeline  103 , the cavity inlet pipeline  105 , the cavity outlet pipeline  106 , and the liquid return pipeline  104  can all be flexible pipes made of soft materials. The flexible pipe may also have light-shielding properties to meet the requirements of that certain drugs for bladder  10 ′ chemotherapy need to be shielded from light. 
     The two-way valve  440 , the dosing joint  450 , the pressure measuring assembly  430 , the cavity inlet flow indicator  460 , the cavity inlet thermometer  470 , the cavity outlet thermometer  470 ′, the filter  480 , the cavity outlet flow indicator  460 ′ and the flow regulating valve  490  can be connected in series to the pipeline system through a pure physical connection method in which the joint  20  and a locking sleeve  30  are matched, which may prevent the residue of an adhesive. 
     Specifically, a channel  20   a  is formed on the joint  20 , and the liquid is in communication with the pipeline system through the channel  20 a. The joint  20  includes a matching section  21  and a connecting section  22 . A first protrusion  23  is formed on an outer side wall of the matching section  21 . An outer side wall of the connecting section  22  is a conical surface. The locking sleeve  30  includes a first locking section  31  and a second locking section  32 . A second protrusion  33  matched with the first protrusion  23  is formed on an inner side wall of the first locking section  31 . An inner side wall of the second locking section  32  protrudes to form a pressing portion. The flexible pipe is compressed between the pressing portion and the connecting section  22 . 
     When the locking sleeve  30  is matched with the joint, the locking sleeve  30  is sleeved into the flexible pipes in advance, and then one end of the flexible pipe is sleeved on the connecting section  22  of the joint. The flexible pipe is stretched by the connecting section  22  when being sleeved on the connecting section  22 . The locking sleeve  30  is moved until the second protrusion  33  on the inner side wall of the first locking sleeve  30  passes through the first protrusion  23  on the outer side wall of the matching section  21 , and the pressing portion of the inner side wall of the second locking section  32  has a certain pressing effect on the flexible pipe, so that the flexible pipe can be compressed between the connecting section  22  and the second locking section  32 , which may prevent the flexible pipe from detaching from the joint. 
     Specifically, in the present embodiment, the device of intracavitary circulatory hyperthermic perfusion  10  further includes an intracavitary pressure measuring sensor  700 , which is used to measure a pressure value in the bladder  10 ′. 
     Specifically, in the present embodiment, the controller includes a main control unit, a data acquisition unit, a power control unit, and a driving control unit. The data acquisition unit, the power control unit, and the driving control unit are electrically coupled to the main control unit. The touch display  500  is also electrically coupled to the main control unit. The weight data measured by the weighing sensor are transmitted to the data acquisition unit, and the data acquisition unit transmits weight data signals to the main control unit, which controls the electromagnetic induction coil to be powered on or powered off. The heating power of the electromagnetic induction coil is controlled by the power control unit to ensure that the treatment temperature is maintained at about 45° C. for a long time. The driving control unit is configured to control the first driving source and the second driving source. The first driving source drives the lifting platform to perform the lifting movement, and the second driving source drives the valve core to rotate relative to the valve body to achieve the purpose of opening and closing of the two-way valve. 
     The main control unit also obtains the temperature values of the medicinal solution measured by the first temperature sensor, the second temperature sensor, and the third temperature sensor in real time through the data acquisition unit, thereby obtaining the temperature values of the medicinal solution in the heating tank, the liquid outlet pipeline, and the liquid return pipeline. The touch display  500  can display the temperature values of the medicinal solution in the heating tank, the liquid outlet pipeline, and the liquid return pipeline. The main control unit also obtains the pressure value in the bladder  10 ′ measured by the intracavitary pressure measuring sensor  700  through the data acquisition unit. The touch display  500  can display the pressure value, so that the pressure value in the heating tank can be adjusted by adjusting the sealing cap on the heating tank, which ensures that the temperature and the pressure in the bladder  10 ′ are in a completely effective state. Thus, the effective killing effect of thermotherapy and chemotherapy on superficial bladder  10 ′ cancer can be better exerted. 
     Meanwhile, the total amount of the medicinal solution entering the bladder  10 ′ calculated by the weighing sensor in real time is acquired by the data acquisition unit, and the pressure value in the bladder  10 ′ monitored by the intracavitary pressure measuring sensor is acquired by the data acquisition unit. Based on this, the rotate speed of the roller pump is adjusted automatically, thereby adjusting the speed and the total amount of the medicinal solution entering the bladder  10 ′, and ensuring that the pressure in the bladder  10 ′ is within a safety threshold. When the relevant parameters such as the treatment temperature, the pressure and the like exceed the threshold value, automatic alarm protection is carried out. 
     The above-mentioned device of intracavitary circulatory hyperthermic perfusion  10  has at least the following advantages. 
     In use, the contact pin  108  is inserted into the medicinal solution bag, and the controller controls the driving mechanism  442  to drive the valve core  4411  of the two-way valve  440  to rotate relative to the valve body  4412 , so that the two-way valve  440  is in an open state. The medicinal solution in the medicinal solution bag enters the liquid storage cavity  410   a  of the heating tank  410  through the liquid inlet pipeline  101 , and the chemotherapeutic drug and the like can be injected into the liquid inlet pipeline  101  through the dosing joint  450 . Since the heating tank  410  is the non-deformable tank structure, the sealing cap needs to be opened at this time, otherwise, the medicinal solution cannot be injected into the heating tank  410  due to an airtightness of the pipeline. The heating tank  410  is carried on a tray. When the weighing sensor detects that the amount of the medicinal solution in the heating tank  410  reaches a set value, the controller controls the driving mechanism  442  again to drive the valve core  4411  to rotate relative to the valve body  4412 , so that the two-way valve  440  is closed, and the liquid inlet pipeline  101  is in a closed state. The medicinal solution in the heating tank  410  is preheated by the electromagnetic induction heating device until a preheating temperature is reached. 
     When the pipeline system needs to be pre-filled, the driving control unit drives the circulation pump  420  to drive the medicinal solution to flow. At this time, the pre-filling valve  1031  is opened, and the cavity inlet valve  1051  and the cavity outlet valve  1061  are closed. The medicinal solution is extracted out of the liquid storage cavity  410   a  under the action of the circulation pump  420 . The pressure measuring assembly  430  is externally connected to the pressure measuring sensor and measures the pressure of the liquid in the liquid outlet pipeline  102 . The medicinal solution passes through the cavity inlet flow indicator  460  and cavity inlet thermometer  470  in the liquid outlet pipeline  102 , then is introduced into the pre-filling pipeline  103 , and then flows back to the heating tank  410  through the cavity outlet thermometer  470 ′, the filter  480 , the cavity outlet flow indicator  460 ′, and the flow regulating valve  490  in the liquid return pipeline  104 . The medicinal solution flows back to the heating tank  410  through the liquid outlet pipeline  102 , the pre-filling pipeline  103 , and the liquid return pipeline  104 , so that the air in the pipeline system can be exhausted in advance to avoid causing inflammation. 
     Then, the pre-filling valve  1031  is closed, the cavity inlet valve  1051  and the cavity outlet valve  1061  are opened. The medicinal solution is extracted out of the liquid storage cavity  410   a  again under the action of the circulation pump  420 , and then enters the bladder  10 ′ through the liquid outlet pipeline  102  and the cavity inlet pipeline  105 . The pressure in the bladder  10 ′ increases along with the increase of the medicinal solution in the bladder  10 ′. At this time, the medicinal solution flows back to the heating tank  410  through the cavity outlet pipeline  106  and the liquid return pipeline  104  under the action of the pressure difference and gravity of the bladder  10 ′ itself, thereby forming a continuous circulation of the medicinal solution. 
     During the circulation process of the medicinal solution, the heating tank  410  can continuously heat the medicinal solution until the set temperature is reached, which achieves the purpose of simultaneous circulating and heating, thereby preventing the temperature of the medicinal solution from being rapidly heated at the beginning and avoiding the contraction or spasm of the bladder  10 ′. Since the medicinal solution is heated to the predetermined temperature before being introduced into the bladder  10 ′ for treatment, after the medicinal solution is introduced into the bladder  10 ′, a thermal killing mechanism can be fully exerted, metastatic cancer cells that are widely planted on serosa are killed, and the lesions that cause the malignant effusion can be eliminated, so that the purpose of effectively treating the cancerous effusion is achieved, and the treatment effect is effectively improved. 
     The above-mentioned embodiments only express several implementation manners of the present disclosure, and their descriptions are more specific and detailed, but they cannot be understood as limiting the scope of the invention disclosure. It should be noted that, for those of ordinary skill in the art, without departing from the concept of the present disclosure, several modifications and improvements can be made, which all belong to the protection scope of the present disclosure. Therefore, the protection scope of the invention disclosure shall be subject to the appended claims.