Patent Publication Number: US-8993565-B2

Title: (6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors

Description:
This application is a divisional of U.S. patent application Ser. No. 13/338,011, filed Dec. 27, 2011, which is a Continuation of International Application No. PCT/FR2010/051375, filed Jul. 1, 2010, which claims the benefit of U.S. Provisional Application No. 61/241,100 filed on Sep. 1, 2009. 
    
    
     The present invention relates to novel chemical compounds (6-oxo-1,6-dihydropyrimidin-2-yl)amide), derived from pyrimidinones, to the process for the preparation thereof, to the novel intermediates obtained, to the use thereof as medicaments, to the pharmaceutical compositions containing them and to the novel use of such derivatives. 
     The present invention thus also relates to the use of said derivatives for the preparation of a medicament for use in the treatment of humans. 
     More particularly, the invention relates to novel pyrimidinone derivatives and to the pharmaceutical use thereof for the prevention and treatment of conditions capable of being modulated by inhibition of the PI3K/AKTmTOR pathway. AKT is a key participant in the signalling pathway. A high level of AKT phosphorylation is the mark of the activation of the pathway, which is found in many human cancers. 
     The products of the present invention may thus in particular be used for the prevention or treatment of conditions capable of being modulated by inhibition of AKT phosphorylation (P-AKT). The inhibition of P-AKT may especially be obtained by inhibition of the PI3K/AKTmTOR pathway, and in particular by inhibition of kinases belonging to this pathway, for instance receptor tyrosine kinases such as EGFR, IGFR, ErbB2, 3′-phosphoinositide-dependent protein kinase-1 (PDK1), the PI3K phosphoinositide kinase, the AKT serine-threonine kinase, or the mTOR kinase. 
     The inhibition and regulation of the PI3K/AKTmTOR pathway constitutes in particular a new and powerful mechanism of action for the treatment of a large number of cancer diseases including solid and liquid tumours. 
     Such conditions that can be treated by the products of the present application are solid or liquid human tumours. 
     Role of the PI3K/AKT/mTOR pathway 
     The PI3K/AKTmTOR signalling pathway is a complex network which regulates multiple cell functions, such as growth, survival, proliferation and cell growth, which are key processes in tumour regenesis. 
     This signalling pathway is an important target in the treatment of cancer since most of its effectors are altered in human tumours. The principal effectors contribute to the activation of the pathway are i) oncogenes, such as ErbB1 (EGFR), ErbB2 (HER2), PIK3CA and AKT, activated by mutation, amplification or overexpression; ii) a deficiency in tumour suppressor genes such as PTEN, TSC1/2, LKB and PML, which are inactivated following mutations or deletions (Jiang L-Z &amp; Liu L-Z, Biochim Biophys Acta, 2008, 1784:150; Vivanco I &amp; Sawyers C L, 2002, Nat Rev Cancer, 2:489; Cully M et al., Nature Rev. Cancer, 2006, 6:184). 
     The activation of the oncogenes of this signalling pathway is found in many human cancer diseases:
         PIK3CA activating mutations are present in 15-30% of colon, breast, endometrial, liver, ovarian and prostate cancers (TL Yuan and LC Cantley, Oncogene, 2008, 27:5497; Y. Samuels et al. Science, 2004, 304:554; KE. Bachman et al. Cancer Biol Ther, 2004, 3:772; DA Levine et al. Clin Canc Res. 2005, 11:2875; C. Hartmann et al. Acta Neuropathol. 2005, 109:639);   amplifications, activating mutations and overexpressions of RTKs such as EGFR and HER2 in brain, breast and lung (NSCLC) cancers;   amplification and activating overexpression of AKT in brain, lung (NSCLC), breast, kidney, ovarian and pancreatic cancers (Testa J R. and Bellacosa A., Proct. Natl. Acad. Sci. USA 2001, 98:10983; Cheng et al., Proct. Natl. Acad. Sci. USA 1992, 89: 9267; Bellacosa et al., Int. J. Cancer, 1995, 64:280; Cheng et al., Proct. Natl. Acad. Sci. USA 1996, 93:3636; Yuan et al., Oncogene, 2000, 19:2324).       

     Deficiency in the tumour suppressor genes of this signalling pathway is also found in many human cancer diseases:
         deletion of PTEN in 50% of lung (NSCLC), liver, kidney, prostate, breast, brain, pancreatic, endometrial and colon cancers (Maxwell G L et al. Canc. Res. 1998, 58:2500; Zhou X-P et al. Amer. J. Pathol., 2002, 161:439; Endersby R &amp; Baker S J, Oncogene, 2008, 27:5416; Li et al. Science, 1997, 275:1943; Steack P A et al., Nat. Genet., 1997, 15:356);   mutations in TSC12 in more than 50% of tuberous scleroses;   mutations or deletions in LKB1 (or STK11) which predispose to gastrointestinal tract cancers and to pancreatic cancer and which are found in particular in 10-38% of lung adenocarcinomas (Shah U. et al. Cancer Res. 2008, 68:3562);   modifications of PML in particular by translocation in human tumours (Gurrieri C and al, J. NAtl Cancer Inst. 2004, 96:269).       

     In addition, this signalling pathway is a major factor for resistance to chemotherapy, to radiotherapy and to targeted therapies such as EGFR and HER2 inhibitors, for example (C. Sawyers et al. Nat Rev 2002). 
     Role of AKT 
     AKT (proteine kinase B; PKB) is a serine-threonine kinase which occupies a central place in one of the major cell signalling pathways, the PI3K/AKT pathway. AKT is in particular involved in the growth, proliferation, and survival of tumour cells. AKT activation occurs in two steps, (i) by phosphorylation of threonine 308 (P-T308) by PDK1 and (2) by phosphorylation of serine 473-(P-S473) by mTORC2 (or mTOR-Rictor complex), resulting in complete activation. AKT in turn regulates a large number of proteins, including mTOR (mammalian target of Rapamycin), BAD, GSK3, p21, p27, FOXO or FKHRLI (Manning B D &amp; Cantley L C, Cell, 2007 129:1261). The activation of AKT promotes the internalisation of nutrients, thereby triggering a process of anabolising metabolisation supporting cell growth and proliferation. In particular, AKT controls the initiation of protein synthesis through a cascade of interactions that occurs by means of TSC12 (tuberous scleroses complex), Rheb and TOR, so as to result in two essential targets of the signalling pathway, p70S6K and 4EBP. AKT also induces inhibiting phosphorylation of the Forkhead transcription factor and inactivation of GSK33, which result in the inhibition of apoptosis and in progression of the cell cycle (Franke T F, Oncogene, 2008, 27:6473). AKT is therefore a target for anticancer therapy and the inhibition of AKT activation by inhibition of the phosphorylation thereof may induce apoptosis of malignant cells and, by the same token, provide a treatment for cancer. 
     Receptor Tyrosine Kinases Such as IGF1R 
     Abnormally high levels of protein kinase activity have been implicated in many diseases resulting from abnormal cell functions. This may originate either directly or indirectly from a dysfunction in the mechanisms for controlling the kinase activity, related to for example an inappropriate mutation, overexpression or activation of the enzyme, or owing to an overproduction or underproduction of cytokines or of growth factors, also involved in the transduction of upstream or downstream signals of kinases. In all these cases, a selective inhibition of the action of kinases leads to the hope of a beneficial effect. 
     The insulin-like growth factor type 1 receptor (IGF-I-R) is a transmembrane receptor tyrosine kinase which binds firstly to IGFI, but also to IGFII and to insulin with a weak affinity. The binding of IGF1 to its receptor leads to oligomerisation of the receptor, activation of the tyrosine kinase, intermolecular autophosphorylation and phosphorylation of cell substrates (principal substrates: IRS1 and Shc). The receptor activated by its ligand induces a mitogenic activity in normal cells. However, IGF-I-R plays an important role in “abnormal” growth. 
     Several clinical reports underline the important role of the IGF-I pathway in the development of human cancers: 
     IGF-I-R is often found overexpressed in many tumour types (breast, colon, lung, sarcoma, prostate, multiple myeloma) and its presence is often associated with a more aggressive phenotype. 
     High concentrations of circulating IGF1 are strongly correlated with a risk of prostate, lung and breast cancer. 
     Furthermore, it has been widely documented that IGF-I-R is necessary for the establishment and maintenance of the transformed phenotype in vitro just as in vivo [Baserga R, Exp. Cell. Res., 1999, 253, pages 1-6]. The kinase activity of IGF-I-R is essential for the transforming activity of several oncogenes: EGFR, PDGFR, SV40 virus broad T antigen, activated Ras, Raf, and v-Src. The expression of IGF-I-R in normal fibroblasts induces a neoplastic phenotype, which can subsequently lead to tumour formation in vivo. IGF-I-R expression plays an important role in substrate-independent growth. IGF-I-R has also been shown to be a protector in chemotherapy- and radiation-induced apoptosis and cytokine-induced apoptosis. Furthermore, the inhibition of endogenous IGF-I-R by a dominant negative, the formation of a triple helix or the expression of an antisense causes a suppression of the transforming activity in vitro and a decrease in tumour growth in animal models. 
     PDK1 
     3′-Phosphoinositide-dependent protein kinase-1 (PDK1) is one of the essential components of the PI3K-AKT signalling pathway. It is a serine-threonine (SerThr) kinase, the role of which is to phosphorylate and activate other SerThr kinases of the AGC family that are involved in the control of cell growth, proliferation and survival and in the regulation of the metabolism. These kinases include protein kinase B (PKB or AKT), SGK (or serum and glucocorticoid regulated kinase), RSK (or p90 ribosomal S6 kinase), p70S6K (or p70 ribosomal S6 kinase) and also various isoforms of protein kinase C (PKC) (Vanhaesebroeck B. &amp; Alessi D R., Biochem J, 2000, 346:561). One of the key roles of PDK1 is therefore the activation of AKT: in the presence of PIP3, which is the second messenger generated by PI3K, PDK-1 is recruited to the plasma membrane via its PH (pleckstrin homology) domain and phosphorylates AKT on threonine 308 located in the activation loop, which is an essential modification for AKT activation. PDK1 is expressed ubiquitously and is a constitutively activate kinase. PDK1 is a key element in the PI3K/AKT signalling pathway for regulating key processes in tumour genesis, such as cell proliferation and survival. Since this pathway is activated in more than 50% of human cancers, PDK1 represents a target for anticancer therapy. The inhibition of PDK1 should result in an effective inhibition of the proliferation and survival of cancer cells and therefore provide a therapeutic benefit for human cancers (Bayascas J R, Cell cycle, 2008, 7:2978; Peifer C. &amp; Alessi D R, ChemMedChem, 2008, 3:1810). 
     Phosphoinositide 3-kinases (PI3Ks) 
     The PI3K lipid kinase is an important target in this signalling pathway for oncology. The class I PI3Ks are divided up into class Ia (PI3Kα,β,δ) activated by receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs), GTPases of the family Rho and p21-Ras, and class Ib (PI3Kγ) activated by GPCRs and p21-Ras. The class Ia PI3Ks are heterodimers which consist of a catalytic subunit p110a, 6 or 6 and a regulatory subunit p85 or p55. The class Ib (p110γ) is monomeric. The class I PI3Ks are lipidprotein kinases which are activated by RTKs, GPCRs or Ras after recruitment to the membrane. These class I PI3Ks phosphorylate phosphatidylinositol 4,5-diphosphate (PIP2) on position 3 of the inositol so as to give phosphatidylinositol 3,4,5-triphosphate (PIP3), a key secondary messenger in this signalling pathway. In turn, PIP3 recruits AKT and PDK1 to the membrane, where they bind via their pleckstrin homology domain (PH domain), resulting in activation of AKT by PDK1 phosphorylation on threonine 308. AKT phosphorylates many substrates, thus playing a key role in many processes resulting in cell transformation, such as cell proliferation, growth and survival, and also angiogenesis. 
     The class I PI3Ks are implicated in human cancers: somatic mutations of the PIK3CA gene, which encodes PI3Kα, are found in 15-35% of human tumours, with in particular two principal oncogenic mutations, H1047R (in the kinase domain), and E545K/E542K (in the helical domain), (Y. Samuels et al. Science, 2004, 304:554; TL Yuan and LC Cantley, Oncogene, 2008, 27:5497). PI3K inhibitors are expected to be effective in the treatment of many human cancers exhibiting genetic alterations resulting in the activation of the PI3K/AKT/mTOR pathway (Vogt P. et al., Virology, 2006, 344:131; Zhao L &amp; Vogt P K, Oncogene, 2008, 27:5486). 
     Kinase-inhibiting morpholino-pyrimidinone derivatives are known to those skilled in the art. 
     Application WO 2008148074 describes products which have an mTOR-inhibiting activity. These products are pyrido[1,2-a]pyrimidin-4-ones which differ from the products of the present invention owing to their entirely aromatic nature and their substitutions. 
     Application WO 2008064244 describes the application of the PI3Kβ-inhibiting products TGX-221 and TGX-155 that are of use in the treatment of cancer, and in particular of breast cancer. These products are pyrido[1,2-a]pyrimidin-4-ones previously described in applications WO 2004016607 and WO 2001053266, which differ from the products of the present invention owing to their entirely aromatic nature and their substitutions. 
     Applications WO 2006109081, WO 2006109084 and WO 2006126010 describe DNA-PK-inhibiting products that are of use in the treatment of ATM-deficient cancers. These products are pyrido[1,2-a]pyrimidin-4-ones which differ from the products of the present invention owing to their entirely aromatic nature and their substitutions. 
     Application WO 2003024949 describes DNA-PK-inhibiting products that are of use in the treatment of ATM-deficient cancers. These products are pyrido[1,2-a]pyrimidin-4-ones which differ from the products of the present invention owing to their entirely aromatic nature and their substitutions. 
     Kinase-inhibiting morpholinopyrimidine derivatives are also known to those skilled in the art. 
     Applications WO 2009007748, WO 2009007749, WO 2009007750 and WO 2009007751 describe products which have mTOR-inhibiting and/or PI3K-inhibiting activity, for the treatment of cancers. These products are pyrimidines substituted in the 2, 4 and 6 positions and the products of the present invention differ therefrom owing to the presence of the carbonyl group on the pyrimidinone and also by virtue of the various substituents. 
     The subject of the present invention is the products of formula (I): 
                         
in which:
     R1 represents an aryl or heteroaryl radical optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and hydroxyl, CN, nitro, —COOH, —COOalk, —NRxRy, —CONRxRy, —NRxCORy, —CORy, —NRxCO 2 Rz, alkoxy, phenoxy, alkylthio, alkyl, alkenyl, alkynyl, cycloalkyl, O-cycloalkyl, heterocycloalkyl, aryl and heteroaryl radicals;   the latter alkoxy, phenoxy, alkylthio, alkyl, alkenyl, alkynyl, heterocycloalkyl, aryl and heteroaryl radicals being themselves optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and hydroxyl, alkoxy, NRvRw, heterocycloalkyl or heteroaryl radicals;   the aryl and heteroaryl radicals being, in addition, optionally substituted with one or more alkyl and alkoxy radicals, themselves optionally substituted with one or more halogen atoms;   it being possible for the heterocycloalkyl and heteroaryl radicals to additionally contain an oxo radical;   R represents a hydrogen atom or else forms, with R1, a saturated or partially or totally unsaturated 5- or 6-membered ring fused to an aryl or heteroaryl residue and optionally containing one or more other heteroatoms chosen from O, S, N, NH and Nalk, this bicyclic radical being optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and CO—NH 2 , hydroxyl, alkyl and alkoxy radicals; the latter alkyl radical being itself optionally substituted with a hydroxyl, alkoxy, NH 2 , NHalk or N(alk) 2  radical;   R2 and R3, which may be identical or different, independently represent a hydrogen atom, a halogen atom or an alkyl radical optionally substituted with one or more halogen atoms;   R4 represents a hydrogen atom;   R5 represents a hydrogen atom or an alkyl radical optionally substituted with one or more halogen atoms;   NRvRw being such that Rv represents a hydrogen atom or an alkyl radical and Rw represents a hydrogen atom or a cycloalkyl radical, CO 2 alk, or an alkyl radical optionally substituted with one or more radicals, which may be identical or different, chosen from hydroxyl, alkoxy, NRvRw and heterocycloalkyl radicals; or Rx and Ry form, with the nitrogen atom to which they are attached, a cyclic radical containing from 3 to 10 ring members and optionally one or more other heteroatoms chosen from O, S, NH and N-alkyl, this cyclic radical being optionally substituted;   NRvRw being such that Rv represents a hydrogen atom or an alkyl radical and Rw represents a hydrogen atom or a cycloalkyl radical or an alkyl radical optionally substituted with one or more radicals, which may be identical or different, chosen from hydroxyl, alkoxy and heterocycloalkyl radicals; or Rv and Rw form, with the nitrogen atom to which they are attached, a cyclic radical containing from 3 to 10 ring members and optionally one or more other heteroatoms chosen from O, S, NH and N-alkyl, this cyclic radical being optionally substituted;   the cyclic radicals that Rx and Ry or Rv and Rw, respectively, can form, with the nitrogen atom to which they are attached, being optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and alkyl, hydroxyl, oxo, alkoxy, NH 2 ; NHalk and N(alk) 2  radicals;   Rz represents the values of Ry except for hydrogen;   Rx, Ry and Rz in the —NRxCORy, —CORy and NRxCO 2 Rz radicals being chosen from the meanings indicated above for Rx, Ry and Rz;   all the above alkyl (alk), alkoxy and alkylthio radicals being linear or branched and containing from 1 to 6 carbon atoms,   said products of formula (I) being in all the possible racemic, enantiomeric and diastereoisomeric isomer forms, and also the addition salts with inorganic and organic acids or with inorganic and organic bases, of said products of formula (I).   

     The products of formula (I) according to the invention are therefore such that:
         either R represents H and R1 represents an aryl or heteroaryl radical optionally substituted as defined above or hereinafter,   or R forms, with R1, a saturated or partially or totally unsaturated 5- or 6-membered ring fused to an aryl or heteroaryl residue and optionally containing one or more other heteroatoms chosen from O, S, N, NH and Nalk, this bicyclic radical being optionally substituted as defined above or hereinafter,       the substituents R2, R3, R4 and R5 of said products of formula (I) having the definitions indicated above,   said products of formula (I) being in all the possible racemic, enantiomeric and diastereoisomeric isomer forms, and also the addition salts with inorganic and organic acids or with inorganic and organic bases, of said products of formula (I).   

     The subject of the present invention is thus the products of formula (I) as defined above, in which:
     R1 represents a phenyl, pyridine, thienyl, benzoxazolyl, benzofuryl, indazolyl, indolyl, benzothienyl, benzimidazolyl, benzoxazinyl or tetrahydroquinolyl radical optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and CN, nitro, —COOH, —COOalk, —NRxRy, alkoxy, alkyl, alkynyl and cycloalkyl radicals;   the latter alkoxy, alkyl and alkynyl radicals being themselves optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and hydroxyl, alkoxy, NRvRw, piperidyl, pyrrolidinyl or heteroaryl radicals;   the phenyl and heteroaryl radicals being, in addition, optionally substituted with one or more alkyl and alkoxy radicals;   R represents a hydrogen atom or else forms, with R1, a benzoxazinyl, dihydroindolyl, tetrahydroisoquinolyl, tetrahydroquinolyl or dihydropyrrolopyridyl ring, these rings being optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and CO—NH 2 , hydroxyl, alkyl and alkoxy radicals;   the latter alkyl radical being itself optionally substituted with a hydroxyl, alkoxy, NH 2 , NHalk or N(alk) 2  radical;   R2 and R3, which may be identical or different, independently represent a hydrogen atom, a fluorine atom or an alkyl radical;   R4 represents a hydrogen atom;   R5 represents a hydrogen atom or an alkyl radical;   NRxRy being such that Rx represents a hydrogen atom or an alkyl radical and Ry represents a hydrogen atom or an alkyl radical; or Rx and Ry form, with the nitrogen atom to which they are attached, a cyclic radical containing from 3 to 10 ring members and optionally one or more other heteroatoms chosen from O, S, NH and N-alkyl, this cyclic radical being optionally substituted;   NRvRw being such that Rv represents a hydrogen atom or an alkyl radical and Rw represents a hydrogen atom or an alkyl radical;   all the above alkyl (alk) and alkoxy radicals being linear or branched and containing from 1 to 6 carbon atoms,   said products of formula (I) being in all the possible racemic, enantiomeric and diastereoisomeric isomer forms, and also the addition salts with inorganic and organic acids or with inorganic and organic bases, of said products of formula (I).   

     The subject of the present invention is the products of formula (I): 
                         
in which:
     R1 represents an aryl or heteroaryl radical optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and hydroxyl, CN, nitro, —COOH, —COOalk, —NRxRy, —CONRxRy, —NRxCORy, —CORy, —NRxCO 2 Rz, alkoxy, phenoxy, alkylthio, alkyl, alkenyl, alkynyl, cycloalkyl, O-cycloalkyl, heterocycloalkyl, aryl and heteroaryl radicals;   the latter alkoxy, phenoxy, alkylthio, alkyl, alkenyl, alkynyl, heterocycloalkyl, aryl and heteroaryl radicals being themselves optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and hydroxyl, alkoxy and NRvRw radicals;   the aryl and heteroaryl radicals being, in addition, optionally substituted with one or more alkyl and alkoxy radicals, themselves optionally substituted with one or more halogen atoms;   it being possible for the heterocycloalkyl and heteroaryl radicals to additionally contain an oxo radical;   R represents a hydrogen atom or else forms, with R1, a saturated or partially or totally unsaturated 5- or 6-membered ring fused to an aryl or heteroaryl residue and optionally containing one or more other heteroatoms chosen from O, S, N, NH and Nalk, this bicyclic radical being optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and hydroxyl, alkyl and alkoxy radicals;   R2 and R3, which may be identical or different, independently represent a hydrogen atom, a halogen atom or an alkyl radical optionally substituted with one or more halogen atoms;   R4 represents a hydrogen atom;   R5 represents a hydrogen atom or an alkyl radical optionally substituted with one or more halogen atoms;   NRxRy being such that Rx represents a hydrogen atom or an alkyl radical and Ry represents a hydrogen atom or a cycloalkyl radical or an alkyl radical optionally substituted with one or more radicals, which may be identical or different, chosen from hydroxyl, alkoxy, NRvRw and heterocycloalkyl radicals; or Rx and Ry form, with the nitrogen atom to which they are attached, a cyclic radical containing from 3 to 10 ring members and optionally one or more other heteroatoms chosen from O, S, NH and N-alkyl, this cyclic radical being optionally substituted;   NRvRw being such that Rv represents a hydrogen atom or an alkyl radical and Rw represents a hydrogen atom or a cycloalkyl radical or an alkyl radical optionally substituted with one or more radicals, which may be identical or different, chosen from hydroxyl, alkoxy and heterocycloalkyl radicals; or Rv and Rw form, with the nitrogen atom to which they are attached, a cyclic radical containing from 3 to 10 ring members and optionally one or more other heteroatoms chosen from O, S, NH and N-alkyl, this cyclic radical being optionally substituted;   the cyclic radicals that Rx and Ry or Rv and Rw, respectively, can form, with the nitrogen atom to which they are attached, being optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and alkyl, hydroxyl, oxo, alkoxy, NH 2 ; NHalk and N(alk) 2  radicals;   Rz represents the values of Ry except for hydrogen;   Rx, Ry and Rz in the —NRxCORy, —CORy and NRxCO 2 Rz radicals being chosen from the meanings indicated above for Rx, Ry and Rz;   said products of formula (I) being in all the possible racemic, enantiomeric and diastereoisomeric isomer forms, and also the addition salts with inorganic and organic acids or with inorganic and organic bases, of said products of formula (I).   

     In the products of formula (I):
         the term “alkyl (or alk) radical” denotes the linear, and where appropriate branched, radicals methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, hexyl, isohexyl and also heptyl, octyl, nonyl and decyl, and also the linear or branched positional isomers thereof: the alkyl radicals containing from 1 to 6 carbon atoms and more particularly the alkyl radicals containing from 1 to 4 carbon atoms of the above list are preferred;   the term “alkoxy radical” denotes the linear, and where appropriate branched, radicals methoxy, ethoxy, propoxy, isopropoxy, linear, secondary or tertiary butoxy, pentoxy or hexoxy, and also the linear or branched positional isomers thereof: the alkoxy radicals containing from 1 to 4 carbon atoms of the above list are preferred;   the term “alkylthio radical” denotes the linear, and where appropriate branched, radicals methylthio, ethylthio, propylthio, isopropylthio, linear, secondary or tertiary butylthio, pentylthio or hexylthio, and also the linear or branched positional isomers thereof: the alkylthio radicals containing from 1 to 4 carbon atoms of the above list are preferred;   the term “halogen atom” denotes chlorine, bromine, iodine or fluorine atoms, and preferably the chlorine, bromine or fluorine atom;   the term “cycloalkyl radical” denotes a saturated carbocyclic radical containing 3 to 10 carbon atoms and thus denotes in particular cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl radicals, and most particularly cyclopropyl, cyclopentyl and cyclohexyl radicals;   in the —O-cycloalkyl radical, cycloalkyl is as defined above;   the term “heterocycloalkyl radical” thus denotes a monocyclic or bicyclic carbocyclic radical containing from 3 to 10 ring members, interrupted with one or more heteroatoms, which may be identical or different, chosen from oxygen, nitrogen or sulphur atoms: mention may, for example, be made of morpholinyl, thiomorpholinyl, homomorpholinyl, aziridyl, azetidyl, piperazinyl, piperidyl, homopiperazinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, tetrahydrofuryl, tetrahydrothienyl, tetrahydropyran, oxodihydropyridazinyl or else oxetanyl radicals, all these radicals being optionally substituted; mention may in particular be made of morpholinyl, thiomorpholinyl, homomorpholinyl, piperazinyl, piperidyl, homopiperazinyl or else pyrrolidinyl radicals;   the terms “aryl” and “heteroaryl” denote monocyclic or bicyclic, respectively carbocyclic and heterocyclic, unsaturated or partially unsaturated radicals containing at most 12 ring members, that may optionally contain a —C(O) ring member, the heterocyclic radicals containing one or more heteroatoms, which may be identical or different, chosen from O, N, or S, with N, where appropriate, being optionally substituted;   the term “aryl radical” thus denotes monocyclic or bicyclic radicals containing 6 to 12 ring members, such as, for example, phenyl, naphthyl, biphenyl, indenyl, fluorenyl and anthracenyl radicals, more particularly phenyl and naphthyl radicals, and even more particularly the phenyl radical. It may be noted that a carbocyclic radical containing a —C(O) ring member is, for example, the tetralone radical;   the term “heteroaryl radical” thus denotes monocyclic or bicyclic radicals containing 5 to 12 ring members: monocyclic heteroaryl radicals such as, for example, the radicals: thienyl, such as 2-thienyl and 3-thienyl, furyl, such as 2-furyl or 3-furyl, pyranyl, pyrrolyl, pyrrolinyl, pyrazolinyl, imidazolyl, pyrazolyl, pyridyl, such as 2-pyridyl, 3-pyridyl and 4-pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, oxazolyl, thiazolyl, isothiazolyl, diazolyl, thiadiazolyl, thiatriazolyl, oxadiazolyl, isoxazolyl, such as 3- or 4-isoxazolyl, furazanyl, free or salified tetrazolyl, all these radicals being optionally substituted, among which are more particularly the radicals: thienyl, such as 2-thienyl and 3-thienyl, thiazolyl, furyl, such as 2-furyl, pyrrolyl, pyrrolinyl, pyrazolinyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, pyridyl and pyridazinyl, these radicals being optionally substituted; bicyclic heteroaryl radicals such as, for example, the radicals: benzothienyl (benzothiophene), such as 3-benzothienyl, benzothiazolyl, quinolyl, isoquinolyl, dihydroquinolyl, quinolone, tetralone, adamentyl, benzofuryl, isobenzofuryl, dihydrobenzofuran, ethylenedioxyphenyl, thianthrenyl, benzopyrrolyl, benzimidazolyl, benzoxazinyl, benzoxazolyl, thionaphthyl, indolyl, dihydroindolyl, azaindolyl, indazolyl, purinyl, thienopyrazolyl, tetrahydroindazolyl, tetrahydroquinolyl, tetrahydroisoquinolyl, tetrahydrocyclopentapyrazolyl, dihydrofuropyrazolyl, dihydropyrrolopyridyl, tetrahydropyrrolopyrazolyl, oxotetrahydropyrrolo-pyrazolyl, tetrahydropyranopyrazolyl, tetrahydropyridinopyrazolyl or oxodihydropyridinopyrazolyl, all these radicals being optionally substituted.       

     As examples of heteroaryl or bicyclic radicals, mention may more particularly be made of pyrimidinyl, pyridyl, pyrrolyl, azaindolyl, indazolyl or pyrazolyl, benzothiazolyl or benzimidazolyl radicals optionally substituted with one or more substituents, which may be identical or different, as indicated above. 
     The carboxyl radical(s) of the products of formula (I) may be salified or esterified with the various groups known to those skilled in the art, among which mention may be made, for example of:
         among the salification compounds, inorganic bases such as, for example, an equivalent of sodium, of potassium, of lithium, of calcium, of magnesium or of ammonium, or organic bases such as, for example, methylamine, propylamine, trimethylamine, diethylamine, triethylamine, N, N-dimethylethanolamine, tris(hydroxymethyl)aminomethane, ethanolamine, pyridine, picoline, dicyclohexylamine, morpholine, benzylamine, procaine, lysine, arginine, histidine and N-methylglucamine;   among the esterification compounds, the alkyl radicals for forming alkoxycarbonyl groups, such as, for example, methoxycarbonyl, ethoxycarbonyl, tert-butoxycarbonyl or benzyloxycarbonyl, it being possible for these alkyl radicals to be substituted with radicals chosen, for example, from halogen atoms and hydroxyl, alkoxy, acyl, acyloxy, alkylthio, amino or aryl radicals, as, for example, in chloromethyl, hydroxypropyl, methoxymethyl, propionyloxymethyl, methylthiomethyl, dimethylaminoethyl, benzyl or phenethyl groups.       

     The addition salts with inorganic or organic acids of the products of formula (I) may, for example, be the salts formed with hydrochloric acid, hydrobromic acid, hydroiodic acid, nitric acid, sulphuric acid, phosphoric acid, propionic acid, acetic acid, trifluoroaectic acid, formic acid, benzoic acid, maleic acid, fumaric acid, succinic acid, tartaric acid, citric acid, oxalic acid, glyoxylic acid, aspartic acid, ascorbic acid, alkoylmonosulphonic acids such as, for example, methanesulphonic acid, ethanesulphonic acid or propanesulphonic acid, alkoyldisulphonic acids such as, for example, methanedisulphonic acid or alpha, beta-ethanedisulphonic acid, arylmonosulphonic acids such as benzenesulphonic acid, and aryldisulphonic acids. 
     It may be recalled that stereoisomerism can be defined in its broad sense as the isomerism of compounds having the same structural formulae, but the various groups of which are arranged differently in space, such as in particular in monosubstituted cyclohexanes in which the substituent may be in the axial or equatorial position, and the various possible rotational conformations of ethane derivatives. However, another type of stereoisomerism exists, due to the different spatial arrangements of fixed substituents, on double bonds or on rings, which is often referred to as geometrical isomerism or cis-transisomerism. The term “stereoisomerism” is used in the present application in its broadest sense and therefore relates to all the compounds indicated above. 
     The subject of the present invention is the products of formula (I) as defined above, in which:
     R 1  represents a phenyl, pyridine, thienyl, benzoxazole-4-yl or indazol-6-yl radical, optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and CN, nitro, —COOH, —COOalk, —NRxRy, alkoxy, alkyl, alkynyl and cycloalkyl radicals;   the latter alkoxy, alkyl and alkynyl radicals being themselves optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and hydroxyl, alkoxy and NRvRw radicals;   the phenyl and heteroaryl radicals being, in addition, optionally substituted with one or more alkyl and alkoxy radicals;   R represents a hydrogen atom or else forms, with R1, a 1,4-benzoxazin-4-yl or 2,3-dihydroindol-1-yl ring, these rings being optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and hydroxyl, alkyl and alkoxy radicals;   R2 and R3, which may be identical or different, independently represent a hydrogen atom, a fluorine atom or an alkyl radical;   R4 represents a hydrogen atom;   R5 represents a hydrogen atom or an alkyl radical;   NRxRy being such that Rx represents a hydrogen atom or an alkyl radical and Ry represents a hydrogen atom or an alkyl radical; or Rx and Ry form, with the nitrogen atom to which they are attached, a cyclic radical containing from 3 to 10 ring members and optionally one or more other heteroatoms chosen from O, S, NH and N-alkyl, this cyclic radical being optionally substituted;   NRvRw being such that Rv represents a hydrogen atom or an alkyl radical and Rw represents a hydrogen atom or an alkyl radical;   all the above alkyl (alk) and alkoxy radicals being linear or branched and containing from 1 to 6 carbon atoms,   said products of formula (I) being in all the possible racemic, enantiomeric and diastereoisomeric isomer forms, and also the addition salts with inorganic and organic acids or with inorganic and organic bases, of said products of formula (I).   

     In particular, when NRxRy or NRvRw forms a ring as defined above, such an amine ring may be chosen in particular from pyrrolidinyl, pyrazolidinyl, pyrazolinyl, piperidyl, azepinyl, morpholinyl, homomorpholinyl, piperazinyl or homopiperazinyl radicals, these radicals being themselves optionally substituted as indicated above or hereinafter. 
     The NRxRy or NRvRw ring may more particularly be chosen from the radicals: pyrrolidinyl or morpholinyl optionally substituted with one or two alkyl radicals or piperazinyl radicals optionally substituted on the second nitrogen atom with an alkyl, phenyl, or and CH 2 -phenyl radical, themselves optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and alkyl, hydroxyl and alkoxy radicals. 
     The subject of the present invention is most particularly the products of formula (I) as defined above, corresponding to the following formulae:
     2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-phenylacetamide   N-(4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-chlorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(dimethylamino)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2,4-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3,4-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(thiophen-3-yl)acetamide   N-(4-fluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2,3-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3,5-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-chlorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(trifluoromethyl)phenyl]acetamide   N-(3-bromophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(2-methylpropan-2-yl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   methyl 3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate   3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoic acid   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(propan-2-yl)phenyl]acetamide   N-(3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyano-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(1H-indazol-6-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyanophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(5-fluoropyridin-2-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-chloro-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(pyridin-3-yl)acetamide   N-(4-fluoro-2-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-bromo-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(3,4,5-trifluorophenyl)acetamide   N-[4-fluoro-3-(hydroxymethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyclopropylephenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(difluoromethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]propanamide   N-(2,3-dimethylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-fluoro-3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(1,3-benzoxazol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(trifluoromethoxy)phenyl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(propan-2-yloxy)phenyl]acetamide   N-(4-fluoro-2-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-methylpropan-2-yl {2-[3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)phenyl]ethyl}carbamate   N-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-ethynylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(cyclopentyloxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(3-cyclopropyl-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-di hydropyrimidin-2-yl]-N-(2,3,4-trifluorophenyl)acetamide   N-[4-fluoro-3-(trifluoromethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(2-hydroxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-iodophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   methyl 2-fluoro-5-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate   N-(3-ethoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-di hydropyrimidin-2-yl]acetamide   N-(2,4-difluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(2,4,5-trifluorophenyl)acetamide   N-(3,5-dichloro-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(4-fluoro-3-nitrophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-fluoro-5-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoic acid   N-(5-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-bromo-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-chloro-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-bromophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[1-ethyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(4-fluorophenyl)acetamide   N-(1H-indol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluorophenyl)-3-methyl-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]butanamide   N-[4-fluoro-3-(methoxymethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-3-iodophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]acetamide   N-[3-(difluoromethyl)-4-fluorophenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2,2-difluoro-N-(4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3,4-difluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(3-bromo-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[4-fluoro-3-(hydroxymethyl)phenyl]-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyclopropylphenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-3-methoxyphenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(1-benzofur-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-phenylacetamide   N-(3-cyclopropyl-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4-chloro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(3-ethynyl-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(4-hydroxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4,6-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(4-fluoro-3-iodophenyl)-2-(1-methyl-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetamide   2-[2-(4,5-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(2-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-[3-(difluoromethyl)-4-fluorophenyl]-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(3,4,5-trifluorophenyl)acetamide   N-(1-methyl-1H-indol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(4-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(3-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(5-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one   2-[2-(4-chloro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(1-benzothiophen-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-{2-[2-(hydroxymethyl)-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-{2-[2-(piperidin-1-yl)ethoxy]phenyl}acetamide   N-[2-(2-methoxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(4-hydroxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4-methoxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[2-(pyridin-3-ylmethoxy)phenyl]acetamide   3-methyl-2-[2-(4-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-(2-{3-[(dimethylamino)methyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4-bromo-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-{2-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-{2-[(2R)-2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   3-methyl-2-[2-(3-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-{2-[2-(methoxymethyl)-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4-ethoxy-2,3-di hydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   1-{[4-(morpholin-4-yl)-6-oxo-1,6-d hydropyrimidin-2-yl]acetyl}-2,3-dihydro-1H-indole-2-carboxamide   3-methyl-2-[2-(2-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-{2-[(3S)-3-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-{2-[(3R)-3-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(5,6-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4,5-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(1,3-dihydro-2H-isoindol-2-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(1-benzothiophen-4-yl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(5-chloro-3,4-dihydroquinolin-1 (2H)-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-{2-[4-(hydroxymethyl)-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-[4-fluoro-2-(piperidin-4-ylmethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(5-chloro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one   2-[2-(4-bromo-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one   2-(2-{(3S)-3-[(dimethylamino)methyl]-2,3-di hydro-1H-indol-1-yl}-2-oxoethyl)-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-(2-{(3R)-3-[(dimethylamino)methyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-[4-fluoro-2-(2-methoxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(1H-benzimidazol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   methyl 2-hydroxy-3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate   2-[2-(4-methoxy-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one   N-(3-bromo-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3,4-dihydro-2H-1,4-benzoxazin-8-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   methyl 5-fluoro-2-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate   2-(2-{3-[(diethylamino)methyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(5,6-difluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(1,2,3,4-tetrahydroquinolin-8-yl)acetamide   2-[2-(8-chloro-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(2-hydroxy-3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-hydroxy-3-nitrophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyano-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[2-hydroxy-3-(trifluoromethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one
 
and also the addition salts with inorganic and organic acids or with inorganic and organic bases, of said products of formula (I).
   

     The subject of the present invention is most particularly the products of formula (I) as defined above, corresponding to the following formulae:
     2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-phenylacetamide   N-(4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-chlorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(dimethylamino)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2,4-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3,4-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(thiophen-3-yl)acetamide   N-(4-fluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2,3-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3,5-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-chlorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(trifluoromethyl)phenyl]acetamide   N-(3-bromophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(2-methylpropan-2-yl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   methyl 3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate   3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoic acid   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(propan-2-yl)phenyl]acetamide   N-(3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyano-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(1H-indazol-6-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyanophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(5-fluoropyridin-2-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-chloro-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(pyridin-3-yl)acetamide   N-(4-fluoro-2-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-bromo-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(3,4,5-trifluorophenyl)acetamide   N-[4-fluoro-3-(hydroxymethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyclopropylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(difluoromethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]propanamide   N-(2,3-dimethylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-fluoro-3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(1,3-benzoxazol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(trifluoromethoxy)phenyl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(propan-2-yloxy)phenyl]acetamide   N-(4-fluoro-2-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-methylpropan-2-yl {2-[3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)phenyl]ethyl}carbamate   N-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-ethynylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(cyclopentyloxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(3-cyclopropyl-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(2,3,4-trifluorophenyl)acetamide   N-[4-fluoro-3-(trifluoromethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(2-hydroxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-iodophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   methyl 2-fluoro-5-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate   N-(3-ethoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2,4-difluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(2,4,5-trifluorophenyl)acetamide   N-(3,5-dichloro-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(4-fluoro-3-nitrophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-fluoro-5-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoic acid   N-(5-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-bromo-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-chloro-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-bromophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[1-ethyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(4-fluorophenyl)acetamide   N-(1H-indol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluorophenyl)-3-methyl-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]butanamide   N-[4-fluoro-3-(methoxymethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-3-iodophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]acetamide   N-[3-(difluoromethyl)-4-fluorophenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2,2-difluoro-N-(4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3,4-difluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(2,3-di hydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(3-bromo-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[4-fluoro-3-(hydroxymethyl)phenyl]-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyclopropylphenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-3-methoxyphenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(1-benzofur-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-phenylacetamide   N-(3-cyclopropyl-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4-chloro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(3-ethynyl-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(4-hydroxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4,6-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one
 
and also the addition salts with inorganic and organic acids or with inorganic and organic bases, also products of formula (I).
   

     A subject of the present invention is also any process for preparing the products of formula (I) as defined above. 
     The products according to the invention may be prepared using conventional organic chemistry methods. 
     Preparation of Compounds of Formula (I) 
     The products of general formula (I) according to the present invention may in particular be prepared as indicated in general schemes 1A-1C below. In this respect, the methods described cannot constitute a limitation of the scope of the invention, as regards the methods for preparing the claimed compounds. 
     The preparations of the examples of the present invention give illustrations of the schemes below. 
     Such synthesis schemes are part of the present invention: a subject of the present invention is thus also the processes for preparing the products of formula C to (I)-d as defined in general schemes 1A-1C below. 
     
       
         
         
             
             
         
       
     
     In general scheme 1A: 
     The aminal ketene B can be obtained from the iminoether A or from the commercially available aminoacrylate tautomer thereof, by reaction with morpholine in a solvent such as ethanol, at a temperature of between 0° C. and the boiling point of the solvent, according to the process described by Landwehr J. et al. in J. Med. Chem. 2006, 49, 4327-4332. 
     The ester C can be obtained by reaction of the aminal ketene B with the iminoether A, or the aminoacrylate tautomer thereof, in a solvent such as ethanol, at a temperature of between 20° C. and the boiling point of the solvent. 
     Alternatively, the ester C can be obtained by “one-pot” reaction between morpholine and an excess (for example 3 equivalents) of iminoether A (or of the aminoacrylate tautomer thereof), in a solvent such as ethanol, at a temperature of between 20° C. and the boiling point of the solvent. 
     The carboxylate D can be obtained by hydrolysis of the ester C in the presence of a base such as sodium hydroxide or lithium hydroxide, in a solvent such as tetrahydrofuran or methanol, at a temperature of between 0° C. and 30° C. 
     The amides (I)-a can be obtained from the carboxylate D by condensation of an amine R1-NH 2  in the presence of a peptide coupling agent such as, for example, EDCl (ethyl dimethylaminopropyl carbodiimide), DMT-MM [4-(4,6-dimethoxy-1,2,3-triazin-2-yl)-4-methylmorpholinium chloride], BOP [benzotriazol-1-yloxytrisdimethylaminophosphonium hexafluorophosphate], PyBOP [benzotriazol-1-yloxytrispyrrolidinophosphonium hexafluorophosphate], PyBROP [bromotrispyrrol idinophosphonium hexafluorophosphate], HATU [O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyl-uronium) hexafluorophosphate] or an HOBT/EDCl [hydroxybenzotriazole-ethyl dimethylaminopropyl carbodiimide mixture], in a solvent such as N,N-dimethylformamide, pyridine, ethanol, water or methanol, at a temperature of between 20° C. and 50° C., for instance under the conditions described by Kunishima M. et al. in Tetrahedron 2001, 57, 1551-1558. 
     The amides (I)-a can also be obtained from the ester C by reaction of an amine R1-NH 2  in the presence of an agent such as trimethylaluminium or potassium tert-butoxide, in a solvent such as toluene, tetrahydrofuran or N,N-dimethylformamide, at a temperature of between 20° C. and 150° C., for instance under the conditions described by Perreux L. et al. in Tetrahedron 2003 (59) 2185-2189 and by Auzeloux, P et al. in J. Med. Chem. 2000, 43 (2), 190-197. 
                         
In general scheme 1B:
 
     The esters E can be obtained from the ester C by reaction with a compound R5-X (X=Cl, Br, I or triflate), in the presence of a base such as sodium hydroxide, potassium tertbutylate or caesium carbonate, in a solvent such as methanol, ethanol or dioxane, at a temperature of between 0° C. and 50° C., according to, for example, the process described by Noel D. D&#39;Angelo et al. in J. Med. Chem. 2008, 51, 5766-5779. 
     The carboxylates F can be obtained by hydrolysis of the esters E, in the presence of a base such as sodium hydroxide or lithium hydroxide, in a solvent such as tetrahydrofuran or methanol, at a temperature of between 0° C. and 30° C. 
     The amides (I)-b can be obtained from the carboxylates F by condensation of an amine R1-NH 2  in the presence of a peptide coupling agent such as, for example, EDCl (ethyl dimethylaminopropyl carbodiimide), DMT-MM [4-(4,6-dimethoxy-1,2,3-triazin-2-yl)-4-methylmorpholinium chloride], BOP [benzotriazol-1-yloxytrisdimethylaminophosphonium hexafluorophosphate], PyBOP [benzotriazol-1-yloxytrispyrrolidinophosphonium hexafluorophosphate], PyBROP [bromotrispyrrolidinophosphonium hexafluorophosphate], HATU [O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyl-uronium) hexafluorophosphate] or an HOBT/EDCl [hydroxybenzotriazole-ethyl dimethylaminopropyl carbodiimide mixture], in a solvent such as N,N-dimethylformamide, pyridine, ethanol, water or methanol, at a temperature of between 20° C. and 50° C., for instance under the conditions described by Kunishima M. et al. in Tetrahedron 2001, 57, 1551-1558. 
     The amides (I)-b can also be obtained from the esters E by reaction of an amine R1-NH 2 , in the presence of an agent such as trimethyl aluminium, in a solvent such as toluene, at a temperature of between 20° C. and the boiling point of the solvent, for instance under the conditions described by Auzeloux, P et al. in J. Med. Chem. 2000, 43 (2), 190-197. 
                         
In general scheme 1C:
 
     the ester G can be obtained from the ester C by reaction with (Boc) 2 O (tert-butyl dicarbonate), in a solvent such as N,N-dimethylformamide, dioxane, acetonitrile or dichloromethane, in the presence of a base such as, for example, sodium hydride, triethylamine, N,N-diisopropylethylamine or pyridine, at a temperature of between 0° C. and 60° C., according to, for example, the process described by Hioki K. et al. Synthesis 2006, 12, 1931-1933 
     The products H can be obtained from the ester G by reaction with R2-X and then, optionally, with R3-X (X=Cl, Br, I or OTf, and R2 and R3 are alkyl groups), in the presence of a base such as sodium hydroxide, potassium tert-butoxide or caesium carbonate, in a solvent such as methanol, ethanol or dioxane, at a temperature of between 0° C. and 100° C., according to, for example, the process described by Noel D. D&#39;Angelo et al. in J. Med. Chem. 2008, 51, 5766-5779. 
     The product H where R2=R3=F can be obtained by reaction of the product G with N-fluorobenzenesulphonimide, in the presence of a base such as the potassium salt of hexamethyldisilylazane, in a solvent such as tetrahydrofuran, at a temperature of between −78° C. and 20° C., according to, for example, the process described by Christopher S. Burgey et al. in J. Med. Chem. 2003, 46, 461-473. 
     The esters J where the R2 and R3 groups are alkyl radicals can be obtained from the ester C in the same way as the products H, in the presence of a base such as butyllithium, sodium hydride, potassium tert-butoxide or caesium carbonate, in a solvent such as methanol, ethanol, tetrahydrofuran, N,N-dimethylformamide or dioxane, at a temperature of between 0° C. and 50° C. 
     The amides (I)-c can be obtained from the esters H or J by reaction of an amine R1-NH 2 , in the presence of an agent such as trimethyl aluminium, in a solvent such as toluene, at a temperature of between 20° C. and the boiling point of the solvent, for instance under the conditions described by Auzeloux, P et al. in J. Med. Chem. 2000, 43 (2), 190-197. 
     The amides (I)-d can be obtained from the amides (I)-c by reaction with a compound R5-X (X=Cl, Br, I or triflate), in the presence of a base such as sodium hydroxide, potassium tert-butoxide or caesium carbonate, in a solvent such as methanol, ethanol or dioxane, at a temperature of between 0° C. and 50° C., according to, for example, the process described by Noel D. D&#39;Angelo et al., in J. Med. Chem. 2008, 51, 5766-5779. 
     Alternatively, the amides (I)-d can be obtained from the esters K by reaction of an amine R1-NH 2 , in the presence of an agent such as trimethylaluminium, in a solvent such as toluene, at a temperature of between ° C. and the boiling point of the solvent, for instance under the conditions described by Auzeloux, P et al. in J. Med. Chem. 2000, 43 (2), 190-197. 
     The esters K can be obtained from the esters J by reaction with a compound R5-X (X=Cl, Br, I or triflate), in the presence of a base such as sodium hydroxide, potassium tert-butoxide or caesium carbonate, in a solvent such as methanol, ethanol or dioxane, at a temperature of between 0° C. and 50° C., according to, for example, the process described by Noel D. D&#39;Angelo et al. in J. Med. Chem. 2008, 51, 5766-5779. 
     Among the starting products of formula A or B, some are known and can be obtained either commercially, or according to the usual methods known to those skilled in the art, for example from commercially available products. 
     It is understood, for those skilled in the art, that, in order to implement the processes according to the invention, described above, it may be necessary to introduce protective groups for amino, carboxyl and alcohol functions in order to prevent side reactions. 
     The following nonexhaustive list of examples of protection of reactive functions may be mentioned:
         hydroxyl groups can be protected, for example, with alkyl radicals such as tert-butyl, trimethylsilyl, tert-butyldimethylsilyl, methoxymethyl, tetrahydropyranyl, benzyl or acetyl,   amino groups can be protected, for example, with acetyl, trityl, benzyl, tert-butoxycarbonyl, BOC, benzyloxycarbonyl or phthalimido radicals or other radicals known in peptide chemistry.       

     Acid functions can be protected, for example, in the form of esters formed with readily cleavable esters such as benzyl or tert-butyl esters, or esters known in peptide chemistry. 
     A list of various protective groups that can be used will be found in the manuals known to those skilled in the art, and for example in patent BF 2 499 995. 
     It may be noted that it is possible, if desired and if necessary, to subject intermediate products or products of formula (I) thus obtained by means of the processes indicated above, in order to obtain other intermediates or other products of formula (I), to one or more conversion reactions known to those skilled in the art, such as, for example: 
     a) a reaction for esterification of an acid function, 
     b) a reaction for saponification of an ester function to give an acid function, 
     c) a reaction for reduction of the free or esterified carboxyl function to give an alcohol function, 
     d) a reaction for conversion of an alkoxy function to give a hydroxyl function, or else of a hydroxyl function to give an alkoxy function, 
     e) a reaction for removal of the protective groups that the protected reactive functions may be carrying, 
     f) a reaction for salification with an inorganic or organic acid or with a base so as to obtain the corresponding salt, 
     g) a reaction for resolving the racemic forms to give resolved products, said products of formula (I) thus obtained being in all the possible racemic, enantiomeric and diastereoisomeric isomer forms. 
     The reactions a) to g) can be carried out under the usual conditions known to those skilled in the art, such as, for example, those indicated hereinafter.
     a) The products described above may, if desired, be the subject, on the possible carboxyl functions, of esterification reactions which can be carried out according to the usual methods known to those skilled in the art.   b) The possible conversions of ester functions to give acid functions of the products described above may, if desired, be carried out under the usual conditions known to those skilled in the art, in particular by acid or alkaline hydrolysis, for example with sodium hydroxide or potassium hydroxide in an alcohol medium such as, for example, in methanol, or else with hydrochloric acid or sulphuric acid.   

     The saponification reaction can be carried out according to the usual methods known to those skilled in the art, such as, for example, in a solvent such as methanol or ethanol, dioxane or dimethoxyethane, in the presence of sodium hydroxide or of potassium hydroxide.
     c) The possible free or esterified carboxyl functions of the products described above may, if desired, be reduced to give alcohol functions by means of the methods known to those skilled in the art: the possible esterified carboxyl functions may, if desired, be reduced to give alcohol functions by means of the methods known to those skilled in the art, and in particular with lithium aluminium hydride in a solvent such as, for example, tetrahydrofuran, or else dioxane or ethyl ether.   

     The possible free carboxyl functions of the products described above may, if desired, be reduced to give alcohol functions in particular with boron hydride.
     d) The possible alkoxy functions, such as in particular methoxy functions, of the products described above may, if necessary, be converted to hydroxyl functions under the usual conditions known to those skilled in the art, for example with boron tribromide in a solvent such as, for example, methylene chloride, with pyridine hydrobromide or hydrochloride or else with hydrobromic acid or hydrochloric acid in water or trifluoroacetic acid at reflux.   e) The removal of protective groups such as, for example, those indicated above can be carried out under the usual conditions known to those skilled in the art, in particular by acid hydrolysis carried out with an acid such as hydrochloric acid, benzenesulphonic acid, para-toluenesulphonic acid, formic acid or trifluoroacetic acid, or else by catalytic hydrogenation.   The phthalimido group may be removed with hydrazine.   f) The products described above may, if desired, be the subject of salification reactions, for example with an inorganic or organic acid or with an inorganic or organic base, according to the usual methods known to those skilled in the art: such a salification reaction can be carried out, for example, in the presence of hydrochloric acid, or else of tartaric acid, citric acid or methanesulphonic acid, in an alcohol such as, for example, ethanol or methanol.   g) The possible optically active forms of the products described above can be prepared by resolving the racemic mixtures according to the usual methods known to those skilled in the art.   

     The products of formula (I) as defined above, and also the addition salts thereof with acids, have advantageous pharmacological properties, in particular due to their kinase-inhibiting properties, as is indicated above. 
     The products of the present invention are in particular of use in tumour therapy. 
     The products of the invention may also thus increase the therapeutic effects of commonly used antitumour agents. 
     These properties justify the use thereof in therapy, and a subject of the invention is in particular, as medicaments, the products of formula (I) as defined above, said products of formula (I) being in all the possible racemic, enantiomeric and diastereoisomeric isomer forms, and also the pharmaceutically acceptable addition salts with inorganic and organic acids or with inorganic and organic bases, of said products of formula (I). 
     The subject of the invention is most particularly, as medicaments, the products corresponding to the following formulae:
     2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-phenylacetamide   N-(4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-chlorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(dimethylamino)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2,4-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3,4-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(thiophen-3-yl)acetamide   N-(4-fluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2,3-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3,5-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-chlorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(trifluoromethyl)phenyl]acetamide   N-(3-bromophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(2-methylpropan-2-yl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   methyl 3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate   3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoic acid   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(propan-2-yl)phenyl]acetamide   N-(3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyano-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(1H-indazol-6-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyanophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(5-fluoropyridin-2-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-chloro-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(pyridin-3-yl)acetamide   N-(4-fluoro-2-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-bromo-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(3,4,5-trifluorophenyl)acetamide   N-[4-fluoro-3-(hydroxymethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyclopropylephenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(difluoromethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]propanamide   N-(2,3-dimethylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-fluoro-3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(1,3-benzoxazol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(trifluoromethoxy)phenyl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(propan-2-yloxy)phenyl]acetamide   N-(4-fluoro-2-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-methylpropan-2-yl {2-[3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)phenyl]ethyl}carbamate   N-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-ethynylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(cyclopentyloxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(3-cyclopropyl-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(2,3,4-trifluorophenyl)acetamide   N-[4-fluoro-3-(trifluoromethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[3-(2-hydroxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-iodophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   methyl 2-fluoro-5-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate   N-(3-ethoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2,4-difluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(2,4,5-trifluorophenyl)acetamide   N-(3,5-dichloro-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(4-fluoro-3-nitrophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-fluoro-5-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoic acid   N-(5-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-bromo-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-chloro-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-bromophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[1-ethyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(4-fluorophenyl)acetamide   N-(1H-indol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluorophenyl)-3-methyl-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]butanamide   N-[4-fluoro-3-(methoxymethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-3-iodophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]acetamide   N-[3-(difluoromethyl)-4-fluorophenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2,2-difluoro-N-(4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3,4-difluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(3-bromo-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[4-fluoro-3-(hydroxymethyl)phenyl]-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyclopropylphenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(4-fluoro-3-methoxyphenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(1-benzofur-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-phenylacetamide   N-(3-cyclopropyl-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4-chloro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(3-ethynyl-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(4-hydroxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4,6-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(4-fluoro-3-iodophenyl)-2-(1-methyl-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetamide   2-[2-(4,5-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(2-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-[3-(difluoromethyl)-4-fluorophenyl]-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(3,4,5-trifluorophenyl)acetamide   N-(1-methyl-1H-indol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(4-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(3-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(5-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one   2-[2-(4-chloro-2,3-di hydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(1-benzothiophen-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-{2-[2-(hydroxymethyl)-2,3-di hydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-{2-[2-(piperidin-1-yl)ethoxy]phenyl}acetamide   N-[2-(2-methoxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(4-hydroxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4-methoxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}acetamide   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[2-(pyridin-3-ylmethoxy)phenyl]acetamide   3-methyl-2-[2-(4-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-(2-{3-[(dimethylamino)methyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4-bromo-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-{2-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-{2-[(2R)-2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   3-methyl-2-[2-(3-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-{2-[2-(methoxymethyl)-2,3-di hydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4-ethoxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   1-{[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}-2,3-dihydro-1H-indole-2-carboxamide   3-methyl-2-[2-(2-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-{2-[(3S)-3-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-{2-[(3R)-3-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(5,6-difluoro-2,3-di hydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(4,5-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(1,3-dihydro-2H-isoindol-2-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(1-benzothiophen-4-yl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(5-chloro-3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-{2-[4-(hydroxymethyl)-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-[4-fluoro-2-(piperidin-4-ylmethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(5-chloro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one   2-[2-(4-bromo-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one   2-(2-{(3S)-3-[(dimethylamino)methyl]-2,3-di hydro-1H-indol-1-yl}-2-oxoethyl)-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-(2-{(3R)-3-[(dimethylamino)methyl]-2,3-di hydro-1H-indol-1-yl}-2-oxoethyl)-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-[4-fluoro-2-(2-methoxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(1H-benzimidazol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   methyl 2-hydroxy-3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate   2-[2-(4-methoxy-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one   N-(3-bromo-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3,4-dihydro-2H-1,4-benzoxazin-8-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   methyl 5-fluoro-2-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate   2-(2-{3-[(diethylamino)methyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   2-[2-(5,6-difluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one   2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(1,2,3,4-tetrahydroquinolin-8-yl)acetamide   2-[2-(8-chloro-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one   N-(2-hydroxy-3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(2-hydroxy-3-nitrophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-(3-cyano-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   N-[2-hydroxy-3-(trifluoromethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide   2-[2-(3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one
 
and also the pharmaceutically acceptable addition salts with inorganic and organic acids or with inorganic and organic bases of said products of formula (I).
   

     The invention also relates to pharmaceutical compositions containing, as active ingredient, at least one of the products of formula (I) as defined above or a pharmaceutically acceptable salt of this product or a prodrug of this product, and, where appropriate, a pharmaceutically acceptable carrier. 
     The invention also extends to the pharmaceutical compositions containing, as active ingredient, at least one of the medicaments as defined above. 
     Such pharmaceutical compositions of the present invention may also, where appropriate, contain active ingredients of other antimitotic medicaments, such as, in particular, those based on taxol, cis-platin, DNA-intercalating agents, and the like. 
     These pharmaceutical compositions may be administered orally, parenterally or locally by topical application to the skin and the mucous membranes, or by intravenous or intramuscular injection. 
     These compositions may be solid or liquid and may be in all the pharmaceutical forms commonly used in human medicine, such as, for example, simple or sugar-coated tablets, pills, lozenges, gel capsules, drops, granules, injectable preparations, ointments, creams or gels; they are prepared according to the usual methods. The active ingredient may be incorporated therein in excipients customarily used in pharmaceutical compositions, such as talc, gum arabic, lactose, starch, magnesium stearate, cocoa butter, aqueous or nonaqueous carriers, fatty substances of animal or plant origin, paraffin derivatives, glycols, various wetting agents, dispersants or emulsifiers, and preservatives. 
     The usual dosage, which is variable according to the product used, the individual treated and the condition in question, may, for example, be from 0.05 to 5 g per day in adults, or preferably from 0.1 to 2 g per day. 
     Such a medicament may in particular be for use in the treatment or prevention of a disease in a mammal. 
     The subject of the present invention is in particular the use of a product of formula (I) as defined above, for the preparation of a medicament for use in the prevention or treatment of diseases associated with an uncontrolled proliferation. 
     The subject of the present invention is thus most particularly the use of a product of formula (I) as defined above, for the preparation of a medicament for use in the treatment or prevention of diseases in oncology, and in particular for use in the treatment of cancers. 
     Among these cancers, the focus is on the treatment of solid or liquid tumours, and on the treatment of cancers resistant to cytotoxic agents. 
     The cited products of the present invention may especially be used in the treatment of primary tumours and/or of metastases, in particular in gastric, hepatic, renal, ovarian, colon, prostate, endometrial and lung (NSCLC and SCLC) cancers, glioblastomas, thyroid, bladder and breast cancers, in melanoma, in lymphoid or myeloid hematopoietic tumours, in sarcomas, in brain, larynx and lymphatic system cancers, bone and pancreatic cancers, and in hamartomas. 
     The subject of the present invention is also the use of the products of formula (I) as defined above, for the preparation of medicaments for use in cancer chemotherapy. 
     The subject of the present invention is thus the products of formula (I) as defined above, for their use in the treatment of cancers. 
     The subject of the present invention is the products of formula (I) as defined above, for their use in the treatment of solid or liquid tumours. 
     The subject of the present invention is therefore the products of formula (I) as defined above, for their use in the treatment of cancers resistant to cytotoxic agents. 
     The subject of the present invention is therefore the products of formula (I) as defined above, for their use in the treatment of primary tumours and/or of metastases, in particular in gastric, hepatic, renal, ovarian, colon, prostate, endometrial and lung (NSCLC and SCLC) cancers, glioblastomas, thyroid, bladder and breast cancers, in melanoma, in lymphoid or myeloid hematopoietic tumours, in sarcomas, in brain, larynx and lymphatic system cancers, bone and pancreatic cancers, and in hamartomas. 
     The subject of the present invention is therefore the products of formula (I) as defined above, for their use in cancer chemotherapy. 
     Such medicaments for use in cancer chemotherapy may be used alone or in combination. 
     The subject of the present invention is therefore the products of formula (1) as defined above, for their use in cancer chemotherapy, alone or in combination. 
     The products of the present application can in particular be administered alone or in combination with chemotherapy or radiotherapy, or else in combination, for example, with other therapeutic agents. 
     Such therapeutic agents may be commonly used antitumour agents. 
     A subject of the present invention is also, as novel industrial products, the synthesis intermediates of formulae C, D, E and F as defined and recalled below: 
                         
in which R5 has the definition indicated in either one of claims  1  and  2 .
 
     The following examples, which are products of formula (I), illustrate the invention without, however, limiting it. 
     Experimental Section 
     The nomenclature of the compounds of this present invention was carried out with the ACDLABS software, version 10.0. 
     The microwave oven used is a Biotage, Initiator™ 2.0, 400 W max, 2450 MHz instrument. 
     The  1 H NMR spectra at 400 MHz and the  1 H NMR spectra at 500 MHz were performed on a Bruker Avance DRX-400 or Bruker Avance DPX-500 spectrometer with the chemical shifts (6 in ppm) in the solvent dimethyl sulphoxide-d 6  (DMSO-d 6 ) referenced at 2.5 ppm at a temperature of 303 K. 
     The mass spectra (MS) were obtained either by method A or by method B: 
     Method A: 
     Waters UPLC-SQD instrument; ionization: positive and/or negative mode electrospray (ES+/−); chromatographic conditions: column: Acquity BEH C18 1.7 μm-2.1×50 mm; solvents: A: H 2 O (0.1% formic acid) B: CH 3 CN (0.1% formic acid); column temperature: 50° C.; flow rate: 1 ml/min; gradient (2 min): from 5% to 50% of B in 0.8 min; 1.2 min: 100% of B; 1.85 min: 100% of B; 1.95: 5% of B; retention time=Tr (min). 
     Method B: 
     Waters ZQ instrument; ionization: positive and/or negative mode electrospray (ES+/−); chromatographic conditions: column: XBridge C 18 2.5 μm-3×50 mm; solvents: A: H 2 O (0.1% formic acid) B: CH 3 CN (0.1% formic acid); column temperature: 70° C.; flow rate: 0.9 ml/min; gradient (7 min): from 5% to 100% of B in 5.3 min; 5.5 min: 100% of B; 6.3 min: 5% of B; retention time=Tr (min). 
    
    
     EXAMPLE 1 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-phenylacetamide 
     Stage 1 
     
       
         
         
             
             
         
       
     
     168.5 ml of ethyl 3-ethoxy-3-iminopropanoate hydrochloride, and then 155 ml of N,N-diisopropylethylamine in 200 ml of ethanol are added to a solution of 25 g of morpholine in 400 ml of ethanol heated to 95° C. The reaction mixture is heated at 95° C. for 30 hours and then allowed to return to ambient temperature. The precipitate formed is filtered off through sintered glass and then washed with 100 ml of ethanol, twice 500 ml of water and, finally, 500 ml of ethyl ether. The solid is dried under vacuum so as to give 35 g of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.19 (t, J=7.1 Hz, 3 H); 3.38 to 3.44 (m, 4 H); 3.56 (s, 2 H); 3.61 (dd, J=4.0 and 5.7 Hz, 4 H); 4.12 (q, J=7.1 Hz, 2 H); 5.20 (s, 1 H); 11.69 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.48; 
     [M+H] + : mz 268; [M−H] − : mz 266. 
     Stage 2 
     
       
         
         
             
             
         
       
     
     18.7 ml of 2M sodium hydroxide are added to a solution of 10 g of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 in 300 ml of tetrahydrofuran. The reaction mixture is stirred for 48 hours at ambient temperature. The precipitate formed is filtered off through sintered glass, washed with ethyl acetate and rinsed several times with ethyl ether. The solid obtained is then dried in a rotary evaporator so as to give 8.7 g of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.08 (s, 2 H); 3.38 (t, J=4.6 Hz, 4 H); 3.61 (t, J=4.6 Hz, 4 H); 5.08 (s, 1 H); 13.16 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.29; 
     [M+H] + : mz 240; [M−H] − : mz 238. 
     Stage 2′ 
     
       
         
         
             
             
         
       
     
     7.5 ml of water and 197 mg of lithium hydroxide are added to a solution of 2 g of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 in 75 ml of methanol. After stirring for 48 hours at ambient temperature, the reaction mixture is concentrated under reduced pressure. 50 ml of water are added. The aqueous phase is then washed with ethyl acetate and then lyophilized. 1.73 g of lithium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate are obtained in the form of a white solid, the characteristics of which are similar to the product of stage 2. 
     Stage 3 
     
       
         
         
             
             
         
       
     
     370 mg of benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 113 mg of 1-hydroxybenzotriazole and 0.140 ml of aniline are added to a solution of 200 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 in 3 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 3 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off and dried in a rotary evaporator. After purification by silica column chromatography, eluent: dichloromethanemethanol 90/10, 161 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-phenylacetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.38 to 3.44 (m, 4H); 3.56 to 3.63 (m, 6 H); 5.20 (s, 1 H); 7.06 (t, J=7.8 Hz, 1 H); 7.31 (t, J=8.6 Hz, 2 H); 7.56 (d, J=8.6 Hz, 2 H); 10.14 (s, 1 H); 11.64 (broad s, 1H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.55; 
     [M+H] + : mz 315; [M−H] − : mz 313. 
     EXAMPLE 2 
     Synthesis of N-(4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in stage 3 of Example 1, using 300 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1, 595 mg of benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 182 mg of 1-hydroxybenzotriazole and 0.235 ml of 4-fluoroaniline in place of aniline. 110 mg of N-(4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of an off-white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.41 (t, J=4.9 Hz, 4 H); 3.55 to 3.64 (m, 6 H); 5.20 (s, 1H); 7.15 (t, J=8.9 Hz, 2 H); 7.58 (dd, J=5.6 and 9.0 Hz, 2 H); 10.20 (s, 1 H); 11.65 (broad s, 1H). 
     Mass spectrometry: method B 
     Retention time Tr (min)=2.86; 
     [M+H] + : mz 333; [M−H] − : mz 331. 
     EXAMPLE 3 
     Synthesis of N-(3-chlorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in stage 3 of Example 1, using 300 mg of lithium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate obtained in stage 2′ of Example 1 and 0.235 ml of 3-chlororoaniline in place of aniline. After purification by silica column chromatography, eluent: dichloromethanemethanolacetonitrile 9055, 71 mg of N-(3-chlorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained, the characteristics of which are the following: 
       1 H NMR spectrum: 3.42 (d, J=5.1 Hz, 4 H); 3.53 to 3.69 (m, 6 H); 5.20 (s, 1 H); 7.12 (d, J=9.0 Hz, 1 H); 7.34 (t, J=8.1 Hz, 1H); 7.42 (dt, J=1.3 and 7.8 Hz, 1 H); 7.77 (t, J=2.1 Hz, 1H); 10.34 (broad s, 1 H); 11.66 (broad s, 1 H). 
     Mass spectrometry: method B 
     Retention time Tr (min)=0.68; 
     [M+H] + : mz 349; [M−H] − : mz 347. 
     EXAMPLE 4 
     Synthesis of N-[3-(dimethylamino)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     0.160 ml of pyridine, 240 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 400 mg of N, N-dimethyl-m-phenylenediamine are added to a solution of 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 in 4 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature overnight and is then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, rinsed with ethyl ether and dried in a rotary evaporator. After purification by silica column chromatography as a solid deposit, eluent: dichloromethanemethanol 95/05, a solid is obtained which is taken up in a mixture of dichloromethane, methanol and ethyl ether. The solid is filtered off and dried. 30 mg of N-[3-(dimethylamino)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a yellow solid, the characteristics of which are the following: 
       1 H NMR spectrum: 2.86 (s, 6 H); 3.41 (t, J=5.0 Hz, 4 H); 3.57 (s, 2 H); 3.60 (t, J=4.9 Hz, 4 H); 5.19 (s, 1 H); 6.44 (d, J=9.3 Hz, 1 H); 6.86 (d, J=7.8 Hz, 1 H); 7.01 (s, 1 H); 7.09 (t, J=8.3 Hz, 1 H); 9.98 (broad s, 1 H); 11.61 (broad s, 1 H). 
     Mass spectrometry: method B 
     Retention time Tr (min)=0.40; 
     [M+H] + : mz 358; [M−H] − : mz 356. 
     EXAMPLE 5 
     Synthesis of N-(2,4-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     2.5 ml of pyridine, 233 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 400 mg of 2,4-difluoroaniline are added to a solution of 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 in 2 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 16 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 205 mg of N-(2,4-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a pinkish solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.43 (t, J=5.0 Hz, 4 H); 3.61 (t, J=5.0 Hz, 4 H); 3.66 (s, 2 H); 5.20 (s, 1 H); 7.01 to 7.13 (m, 1 H); 7.25 to 7.40 (m, 1 H); 7.83 (q, J=7.1 Hz, 1H); 9.97 (broad s, 1H); 11.67 (broad s, 1 H). 
     Mass spectrometry: method B 
     Retention time Tr (min)=0.59; 
     [M+H] + : mz 351; [M−H] − : mz 349. 
     EXAMPLE 6 
     Synthesis of N-(3,4-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 400 mg of 3,4-difluoroaniline in place of the 2,4-difluoroaniline. 210 mg of N-(3,4-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.41 (t, J=4.9 Hz, 4 H); 3.54 to 3.64 (m, 6 H); 5.20 (s, 1H); 7.27 (d, J=8.8 Hz, 1H); 7.39 (dt, J=9.0 and 10.6 Hz, 1 H); 7.64 to 7.79 (m, 1 H); 10.38 (s, 1 H); 11.66 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.64; 
     [M+H] + : mz 351; [M−H] − : mz 349. 
     EXAMPLE 7 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(thiophen-3-yl)acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 400 mg of 3-aminothiophene hydrochloride in place of the 2,4-difluoroaniline. 252 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(thiophen-3-yl)acetamide are obtained in the form of a beige solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.41 (t, J=5.0 Hz, 4 H); 3.51 to 3.64 (m, 6 H); 5.20 (s, 1H); 7.08 (d, J=5.6 Hz, 1 H); 7.35 to 7.56 (m, 2 H); 10.55 (broad s, 1 H); 11.64 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.52; 
     [M+H] + : mz 321; [M−H] − : mz 319. 
     EXAMPLE 8 
     Synthesis of N-(4-fluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 520 mg of 4-fluoro-3-methoxyaniline in place of the 2,4-difluoroaniline. 262 mg of N-(4-fluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.41 (t, J=4.9 Hz, 4 H); 3.56 to 3.62 (m, 6 H); 3.79 (s, 3H); 5.20 (s, 1 H); 7.02 to 7.09 (m, 1 H); 7.10 to 7.17 (m, 1 H); 7.47 (dd, J=2.4 and 8.1 Hz, 1 H); 10.20 (s, 1 H); 11.64 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.60; 
     [M+H] + : mz 363; [M−H] − : mz 361. 
     EXAMPLE 9 
     Synthesis of N-(2-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     In a microwave tube, 300 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 are introduced into 1 ml of N,N-dimethylformamide, 623 mg of 2-fluoroaniline and 378 mg of potassium tert-butoxide. 2 ml of N,N-dimethylformamide are then added. The tube is then microwave-heated at 150° C. for 20 minutes. The reaction mixture is concentrated under reduced pressure. 30 ml of water and 10 ml of ethyl acetate are added and the resulting mixture is thus stirred for 1 h 30. The precipitate formed is filtered off and rinsed with ethyl acetate, ethyl ether and then petroleum ether. The solid obtained is dried in a rotary evaporator and 93 mg of N-(2-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are thus obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.42 (t, J=4.9 Hz, 4 H); 3.61 (t, J=4.6 Hz, 4 H); 3.67 (s, 2 H); 5.19 (s, 1 H); 7.12 to 7.20 (m, 2 H); 7.21 to 7.32 (m, 1 H); 7.81 to 7.98 (m, J=8.3 and 8.3 Hz, 1 H); 10.00 (broad s, 1 H); 11.66 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.56; 
     [M+H] + : mz 333; [M−H] − : mz 331 
     Purity: 94% 
     Melting point (Kofler bench): 279° C. 
     EXAMPLE 10 
     Synthesis of N-(2-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 9, using 300 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 and 582 mg of 2-methylaniline in place of the 2-fluoroaniline. 76 mg of N-(2-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 2.21 (s, 3 H); 3.43 (t, J=5.0 Hz, 4 H); 3.55 to 3.67 (m, 6 H); 5.18 (s, 1 H); 7.08 (t, J=7.8 Hz, 1 H); 7.16 (t, J=7.8 Hz, 1 H); 7.21 (d, J=7.8 Hz, 1H); 7.42 (d, J=7.8 Hz, 1 H); 9.65 (broad s, 1 H); 11.70 (s, 1 H). 
     Mass spectrometry: method B 
     Retention time Tr (min)=2.81; 
     [M+H] + : mz 329; [M−H] − : mz 327 
     Melting point (Kofler bench): 194° C. 
     EXAMPLE 11 
     Synthesis of N-(2-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 9, using 300 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 in 2 ml of N,N-dimethylformamide, 637 mg of 2-methoxyaniline in place of the 2-fluoroaniline, and 300 mg of potassium tert-butoxide. 3 ml of N,N-dimethylformamide are added and the tube is microwave-heated at 150° C. for 20 minutes. The reaction mixture is concentrated under reduced pressure. 15 ml of water and 5 ml of ethyl acetate are added and the resulting mixture is thus stirred for 2 hours. The aqueous phase is extracted with 5 ml of ethyl acetate. The combined organic phases are dried over magnesium sulphate. filtered, and concentrated under reduced pressure. After purification of the solid obtained, on a preparative plate (thickness: 2 mm), elution being carried out with a mixture of dichloromethane and methanol (90/10 by volume), 7 mg of N-(2-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are thus obtained in the form of a pinkish solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.43 (t, J=4.9 Hz, 4 H); 3.59 to 3.65 (m, 4 H); 3.69 (s, 2H); 3.83 (s, 3 H); 5.20 (s, 1 H); 6.90 (ddd, J=2.2 and 6.5 and 8.2 Hz, 1 H); 6.99 to 7.13 (m, 2 H); 7.97 (d, J=8.6 Hz, 1 H); 9.44 (broad s, 1 H); 11.66 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.59; 
     [M+H] + : mz 345; [M−H] − : mz 343. 
     EXAMPLE 12 
     Synthesis of N-(2,3-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 9, using 300 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 and 840 mg of 2,3-difluoroaniline in place of the 2-fluoroaniline. 83 mg of N-(2,3-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.42 (t, J=5.1 Hz, 4H); 3.61 (t, J=5.1 Hz, 4 H); 3.69 (s, 2 H); 5.20 (s, 1 H); 7.18 (t, J=7.0 Hz, 2 H); 7.69 (broad s, 1 H); 10.24 (broad s, 1 H); 11.63 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.61; 
     [M+H] + : mz 351; [M−H] − : m/z 349 
     Melting point (Kofler bench): 248° C. 
     EXAMPLE 13 
     Synthesis of N-(3,5-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 9, using 300 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 and 780 mg of 3,5-difluoroaniline in place of the 2-fluoroaniline. 133 mg of N-(3,5-difluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.41 (t, J=4.9 Hz, 4 H); 3.56 to 3.65 (m, 6 H); 5.20 (s, 1H); 6.92 (t, J=9.3 Hz, 1 H); 7.28 (dd, J=2.2 and 9.5 Hz, 2 H); 10.55 (broad s, 1 H); 11.66 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.66; 
     [M+H] + : mz 351; [M−H] − : mz 349 
     Melting point (Kofler bench)&gt;260° C. 
     EXAMPLE 14 
     Synthesis of N-(3-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 9, using 250 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 and 0.90 ml of 3-fluoroaniline in place of the 2-fluoroaniline. 160 mg of N-(3-fluorophenyl)-2-20 [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.42 (d, J=5.0 Hz, 4 H); 3.57 to 3.62 (m, 6 H); 5.20 (s, 1 H); 6.89 (t, J=9.0 Hz, 1 H); 7.27 (d, J=7.5 Hz, 1 H); 7.31 to 7.40 (m, 1 H); 7.55 (d, J=12.1 Hz, 1 H); 10.38 (broad s, 1 H); 11.66 (broad s, 1H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=2.93; 
     [M+H] + : mz 333; [M−H] − : mz 331. 
     EXAMPLE 15 
     Synthesis of N-(4-chlorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 9, using 250 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 and 1.193 g of 4-chloroaniline in place of the 2-fluoroaniline. 140 mg of N-(4-chlorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.37 to 3.46 (m, J=4.9 Hz, 4 H); 3.51 to 3.66 (m, 6 H); 5.21 (s, 1 H); 7.38 (d, J=8.8 Hz, 2 H); 7.60 (d, J=8.8 Hz, 2 H); 10.34 (broad s, 1 H); 11.71 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.68; 
     [M+H] + : mz 349; [M−H] − : mz 347. 
     EXAMPLE 16 
     Synthesis of N-(3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 9, using 300 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 and 1.254 ml of 3-methoxyaniline in place of the 2-fluoroaniline. 56 mg of N-(3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-di hydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.41 (t, J=5.0 Hz, 4 H); 3.55 to 3.63 (m, 6 H); 3.72 (s, 3H); 5.20 (s, 1 H); 6.64 (dd, J=2.4 and 8.1 Hz, 1 H); 7.08 (ddd, J=0.9 and 1.0 and 8.1 Hz, 1 H); 7.21 (t, J=8.3 Hz, 1 H); 7.27 (s, 1 H); 10.14 (broad s, 1 H); 11.63 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.58; 
     [M+H] + : mz 345; [M−H] − : mz 343. 
     EXAMPLE 17 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-y]-N-[3-(trifluoromethyl)phenyl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 9, using 300 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 and 0.705 ml of 3-(trifluoromethyl)aniline in place of the 2-fluoroaniline. 228 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(trifluoromethyl)phenyl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.37 to 3.46 (m, 4 H); 3.54 to 3.66 (m, 6 H); 5.21 (broad s, 1 H); 7.42 (d, J=8.1 Hz, 1 H); 7.57 (t, J=8.1 Hz, 1 H); 7.75 (d, J=8.3 Hz, 1 H); 8.05 (broad s, 1 H); 10.50 (broad s, 1 H); 11.67 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=3.39; 
     [M+H] + : mz 383; [M−H] − : mz 381. 
     EXAMPLE 18 
     Synthesis of N-(3-bromophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 9, using 300 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 and 0.61 ml of 3-bromoaniline in place of the 2-fluoroaniline. 105 mg of N-(3-bromophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.37 to 3.46 (m, 4 H); 3.54 to 3.66 (m, 6 H); 5.20 (broad s, 1 H); 7.15 to 7.34 (m, 2 H); 7.47 (d, J=8.1 Hz, 1 H); 7.91 (broad s, 1 H); 10.33 (broad s, 1 H); 11.66 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.70; 
     [M+H] + : mz 395; [M−H] − : mz 393. 
     EXAMPLE 19 
     Synthesis of N-[3-(2-methylpropan-2-yl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     224 mg of 3-(tert-butyl)aniline are added to a solution of 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 in 10 ml of methanol. The reaction mixture is stirred at ambient temperature for 5 minutes and then 442 mg of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride hydrate are added. The resulting mixture is thus stirred for 30 minutes at ambient temperature. The reaction mixture is concentrated under reduced pressure. The evaporation residue is taken up with 10 ml of water and 10 ml of ethyl acetate. The resulting product is then stirred for 30 minutes. The precipitate formed is filtered off. 235 mg of N-[3-(2-methylpropan-2-yl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are thus obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 1.26 (s, 9 H); 3.42 (t, J=4.8 Hz, 4 H); 3.53 to 3.64 (m, 6 H); 5.20 (s, 1 H); 7.10 (d, J=8.1 Hz, 1 H); 7.23 (t, J=8.1 Hz, 1 H); 7.41 (d, J=8.1 Hz, 1H); 7.58 (broad s, 1H); 10.09 (broad s, 1 H); 11.65 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.83; 
     [M+H] + : mz 371; [M−H] − : mz 369. 
     EXAMPLE 20 
     Synthesis of methyl 3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 19, using 653 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 and 567 mg of methyl 3-aminobenzoate in place of the 3-(tert-butyl)aniline. 400 mg of methyl 3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.41 (dd, J=4.8 and 5.3 Hz, 4 H); 3.53 to 3.68 (m, 6 H); 3.85 (broad s, 3 H); 5.21 (broad s, 1 H); 7.47 (t, J=8.1 Hz, 1 H); 7.66 (d, J=8.1 Hz, 1 H); 7.80 (d, J=8.3 Hz, 1 H); 8.24 (s, 1 H); 10.00 to 10.64 (m, 1 H); 11.67 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.59; 
     [M+H] + : mz 373; [M−H] − : mz 371 
     Purity: 95%. 
     EXAMPLE 21 
     Synthesis of 3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoic acid 
     
       
         
         
             
             
         
       
     
     1.8 ml of 2 M sodium hydroxide are added to a solution of 335 mg of methyl 3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)-benzoate in 25 ml of methanol. The reaction mixture is heated at 60° C. for 2 h 30, and it is then concentrated under reduced pressure. The evaporation residue is taken up in 50 ml of water. The aqueous phase is extracted with ethyl acetate and then acidified (pH=6) by adding a 1N solution of hydrochloric acid. The precipitate formed is filtered off and then washed with ml of water, 5 ml of ethyl acetate and, finally, 20 ml of ethyl ether. The solid is dried under vacuum and 175 mg of 3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoic acid are thus obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.42 (t, J=4.9 Hz, 4 H); 3.52 to 3.72 (m, 6 H); 5.21 (s, 1 H); 7.43 (t, J=7.9 Hz, 1 H); 7.64 (d, J=7.8 Hz, 1 H); 7.79 (ddd, J=1.5 and 1.6 and 8.2 Hz, 1 H); 8.19 (s, 1 H); 10.36 (s, 1 H); 11.77 (broad s, 1 H); 12.94 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.46; 
     [M+H] + : mz 359; [M−H] − : mz 357. 
     EXAMPLE 22 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(propan-2-yl)phenyl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 19, using 653 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 and using a mixture of 10 ml of water and 2 ml of tetrahydrofuran in place of the methanol and 270 mg of isopropylaniline in place of the 3-(tert-butyl)aniline. 235 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(propan-2-yl)phenyl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 1.18 (d, J=6.8 Hz, 6H); 2.84 (quin, J=6.9 Hz, 1H); 3.42 (t, J=4.9 Hz, 4H); 3.54 to 3.65 (m, 6H); 5.20 (s, 1H); 6.94 (d, J=7.6 Hz, 1H); 7.22 (t, J=7.8 Hz, 1H); 7.38 (d, J=8.8 Hz, 1H); 7.45 (s, 1H); 10.09 (s, 1 H); 11.64 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.78; 
     [M+H] + : mz 357; [M−H] − : mz 355. 
     EXAMPLE 23 
     Synthesis of N-(3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 19, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 and using a mixture of 1 ml of water and 9 ml of ethanol in place of the methanol and 214 mg of 3-methylaniline in place of the 3-(tert-butyl)aniline. 196 mg of N-(3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 2.27 (s, 3 H); 3.38 to 3.45 (m, 4 H); 3.54 to 3.64 (m, 6H); 5.20 (s, 1 H); 6.88 (d, J=7.8 Hz, 1 H); 7.19 (t, J=7.8 Hz, 1 H); 7.35 (d, J=8.8 Hz, 1 H); 7.39 (s, 1 H); 10.07 (s, 1 H); 11.65 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.63; 
     [M+H] + : mz 329; [M−H] − : mz 327. 
     EXAMPLE 24 
     Synthesis of N-(3-cyano-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 19, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 and 163 mg of 5-amino-2-fluorobenzonitrile in place of the 3-(tert-butyl)aniline. The reaction mixture is concentrated to dryness under reduced pressure and the residue is then purified by silica column chromatography, elution being carried out with a gradient of the eluent CH 2 Cl 2 /MeOH: 90/10 in dichloromethane of 0% to 100%. 81 mg of N-(3-cyano-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of an amber solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.34 to 3.47 (m, 4 H); 3.53 to 3.67 (m, 6 H); 5.21 (s, 1H); 7.51 (t, J=9.2 Hz, 1 H); 7.73 to 7.89 (m, 1 H); 8.07 (dd, J=2.8 and 5.7 Hz, 1 H); 10.53 (s, 1 H); 11.68 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.60; 
     [M+H] + : mz 358; [M−H] − : mz 356 
     Purity: 95%. 
     EXAMPLE 25 
     Synthesis of N-(1H-indazol-6-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 19, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 and 280 mg of 1-Boc-6-aminoindazole in place of the 3-(tert-butyl)aniline. The reaction mixture is concentrated under reduced pressure and taken up in 13 ml of 1,4-dioxane and 3 ml of 1N hydrochloric acid, and is then microwave-heated for 10 minutes at 100° C. After cooling to ambient temperature, the reaction mixture is concentrated under reduced pressure and taken up in 30 ml of water, and then a saturated aqueous solution of sodium bicarbonate is added so as to obtain a pH in the region of 8. The precipitate formed is filtered off and washed with water, ethyl acetate and ethyl ether. After purification by silica column chromatography, elution being carried out with a gradient of the eluent CH 2 Cl 2 /MeOH: 7030 in dichloromethane of 0% to 100%, 20 mg of N-(1H-indazol-6-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.42 (t, J=4.9 Hz, 4 H); 3.60 (dd, J=4.0 and 5.7 Hz, 4 H); 3.64 (s, 2 H); 5.20 (s, 1 H); 7.08 (dd, J=1.8 and 8.6 Hz, 1 H); 7.67 (d, J=8.6 Hz, 1 H); 7.96 (s, 1 H); 8.09 (s, 1 H); 10.32 (broad s, 1 H); 11.67 (broad s, 1 H); 12.88 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.45; 
     [M+H] + : mz 355; [M−H] − : mz 353 
     EXAMPLE 26 
     Synthesis of N-(3-cyanophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 19, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 and using a mixture of 6 ml of water and 1 ml of ethyl acetate in place of the methanol, and 118 mg of 3-aminobenzonitrile in place of the 3-(tert-butyl)aniline. 120 mg of N-(3-cyanophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of an off-white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.41 (t, J=4.8 Hz, 4 H); 3.60 (dd, J=4.8 and 5.3 Hz, 4H); 3.63 (s, 2 H); 5.21 (s, 1 H); 7.49 to 7.59 (m, 2 H); 7.78 (dt, J=2.3 and 6.8 Hz, 1 H); 8.04 (s, 1 H); 10.51 (broad s, 1 H); 11.69 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.55; 
     [M+H] + : mz 340; [M−H] − : mz 338. 
     EXAMPLE 27 
     Synthesis of N-(5-fluoropyridin-2-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 19, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 and using a mixture of 7 ml of water and 1.5 ml of tetrahydrofuran in place of the methanol, and 134 mg of 2-amino-5-fluoropyridine in place of the 3-(tert-butyl)aniline. After stirring for 1 h 30 at ambient temperature, a precipitate forms. The reaction mixture is filtered through sintered glass. The solid obtained is washed with water, ethyl acetate and ethyl ether. 130 mg of N-(5-fluoropyridin-2-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of an off-white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.36 to 3.46 (m, 4 H); 3.60 (t, J=5.0 Hz, 4 H); 3.67 (s, 2H); 5.20 (s, 1 H); 7.75 (td, J=2.7 and 6.1 Hz, 1 H); 8.07 (dd, J=9.4 and 4 Hz, 1 H); 8.33 (d, J=2.7 Hz, 1 H); 10.80 (s, 1 H); 11.66 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=2.67; 
     [M+H] + : mz 334; [M−H] − : mz 332. 
     EXAMPLE 28 
     Synthesis of N-(4-fluoro-3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 240 mg of 4-fluoro-3-methylaniline in place of the 2,4-difluoroaniline. 204 mg of N-(4-fluoro-3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 2.20 (d, J=1.2 Hz, 3 H); 3.41 (t, J=4.9 Hz, 4 H); 3.55 to 3.63 (m, 6 H); 5.20 (s, 1 H); 7.07 (t, J=9.2 Hz, 1 H); 7.33 to 7.41 (m, 1 H); 7.46 (dd, J=2.7 and 6.8 Hz, 1 H); 10.13 (s, 1 H); 11.63 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.66; 
     [M+H] + : mz 347; [M−H] − : mz 345. 
     EXAMPLE 29 
     Synthesis of N-(3-chloro-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 278 mg of 3-chloro-4-fluoroaniline in place of the 2,4-difluoroaniline. 218 mg of N-(3-chloro-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.41 (t, J=5.0 Hz, 4 H); 3.56 to 3.63 (m, 6 H); 5.20 (s, 1H); 7.38 (t, J=8.8 Hz, 1 H); 7.41 to 7.50 (m, 1 H); 7.88 (dd, J=2.7 and 6.8 Hz, 1 H); 10.38 (s, 1 H); 11.66 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.70; 
     [M+H] + : mz 367; [M−H] − : mz 365. 
     EXAMPLE 30 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(pyridin-3-yl)acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 427 mg of 3-aminopyridine in place of the 2,4-difluoroaniline. 168 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(pyridin-3-yl)acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.39 to 3.46 (m, 4 H); 3.56 to 3.66 (m, 6 H); 5.20 (broad s, 1 H); 7.35 (broad s, 1 H); 8.00 (d, J=8.6 Hz, 1 H); 8.28 (broad s, 1 H); 8.71 (broad s, 1 H); 10.37 (broad s, 1 H); 11.67 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.25; 
     [M+H] + : mz 316; [M−H] − : mz 314. 
     EXAMPLE 31 
     Synthesis of N-(4-fluoro-2-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 200 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 and 278 mg of 4-fluoro-2-methylaniline in place of the 2,4-difluoroaniline. 92 mg of N-(4-fluoro-2-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a pinkish solid, the characteristics of which are the following: 
       1 H NMR spectrum: 2.21 (s, 3 H); 3.44 (t, J=4.9 Hz, 4 H); 3.57 to 3.66 (m, 6H); 5.19 (s, 1 H); 6.99 (td, J=3.2 and 8.6 Hz, 1 H); 7.08 (dd, J=3.1 and 9.7 Hz, 1 H); 7.36 (dd, J=5.6 and 8.6 Hz, 1 H); 9.56 (broad s, 1 H); 11.67 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.59; 
     [M+H] + : mz 347; [M−H] − : mz 345. 
     EXAMPLE 32 
     Synthesis of N-(3-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 418 mg of 3-aminophenol in place of the 2,4-difluoroaniline. 210 mg of N-(3-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a pinkish solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.37 to 3.47 (m, 4 H); 3.51 to 3.63 (m, 6 H); 5.20 (s, 1H); 6.45 (d, J=8.6 Hz, 1 H); 6.93 (d, J=8.6 Hz, 1 H); 7.07 (t, J=8.6 Hz, 1 H); 7.12 (broad s, 1 H); 9.36 (broad s, 1 H); 10.00 (broad s, 1 H); 11.63 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.43; 
     [M+H] + : mz 331; [M−H] − : mz 329. 
     EXAMPLE 33 
     Synthesis of N-(3-bromo-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 19, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 and using a mixture of 7 ml of water and 1.5 ml of tetrahydrofuran in place of the methanol, and 190 mg of 3-bromo-4-fluoroaniline in place of the 3-(tert-butyl)aniline. 266 mg of N-(3-bromo-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.41 (t, J=4.9 Hz, 4 H); 3.55 to 3.65 (m, 6 H); 5.20 (s, 1H); 7.34 (t, J=8.8 Hz, 1 H); 7.44 to 7.53 (m, 1 H); 8.00 (dd, J=2.2 and 6.1 Hz, 1 H); 10.35 (broad s, 1 H); 11.67 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=3.30; 
     [M+H] + : mz 411; [M−H] − : mz 409 
     EXAMPLE 34 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(3,4,5-trifluorophenyl)acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 200 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 and 113 mg of 3,4,5-trifluoroaniline in place of the 2,4-difluoroaniline. 33 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(3,4,5-trifluorophenyl)acetamide are obtained, the characteristics of which are the following: 
       1 H NMR spectrum: 3.41 (dd, J=4.8 and 5.3 Hz, 4 H); 3.54 to 3.66 (m, 6 H); 5.20 (s, 1 H); 7.46 (dd, J=6.5 and 10.1 Hz, 2 H); 10.55 (s, 1 H); 11.64 (s, 1 H). 
     EXAMPLE 35 
     Synthesis of N-[4-fluoro-3-(hydroxymethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 525 mg of (5-amino-2-fluorophenyl)-methanol in place of the 2,4-difluoroaniline. 218 mg of N-[4-fluoro-3-(hydroxymethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a beige solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.42 (d, J=4.9 Hz, 4 H); 3.55 to 3.64 (m, 6 H); 4.51 (d, J=6.1 Hz, 2 H); 5.20 (broad s, 1 H); 5.27 (t, J=6.0 Hz, 1H); 7.08 (t, J=9.4 Hz, 1 H); 7.46 to 7.54 (m, 1 H); 7.63 (d, J=7.3 Hz, 1 H); 10.18 (broad s, 1 H); 11.64 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.46 
     [M+H] + : mz 363; [M−H] − : mz 361 
     Melting point (Kofler bench)&gt;260° C. 
     EXAMPLE 36 
     Synthesis of N-(3-cyclopropylephenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the following procedure, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 395 mg of 3-cyclopropylaniline (prepared according to Wallace et al., in Tetrahedron Lett. 2002, 43, 6987) in place of the 2,4-difluoroaniline. 225 mg of N-(3-cyclopropylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 0.50 to 0.68 (m, J=2.0 and 4.9 Hz, 2 H); 0.88 to 1.02 (m, 2H); 1.79 to 1.94 (m, J=4.4 and 4.4 Hz, 1 H); 3.42 (t, J=5.1 Hz, 4 H); 3.51 to 3.68 (m, 6 H); 5.20 (s, 1 H); 6.80 (d, J=8.3 Hz, 1 H); 7.17 (t, J=7.8 Hz, 1 H); 7.26 to 7.36 (m, 2 H); 10.06 (broad s, 1 H); 11.63 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.72 
     [M+H] + : mz 353; [M−H] − : mz 355 
     Melting point (Kofler bench)=246° C. 
     EXAMPLE 37 
     Synthesis of N-(2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 500 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 278 mg of 2-aminophenol in place of the 2,4-difluoroaniline. 370 mg of N-(2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.45 (t, J=5.0 Hz, 4 H); 3.59 to 3.65 (m, 4 H); 3.69 (s, 2H); 5.21 (s, 1 H); 6.76 (t, J=7.8 Hz, 1 H); 6.87 (d, J=7.8 Hz, 1 H); 6.92 (t, J=8.5 Hz, 1 H); 7.86 (d, J=7.3 Hz, 1 H); 9.46 (broad s, 1 H); 9.82 (broad s, 1 H); 11.63 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=2.58; 
     [M+H] + : mz 331; [M−H] − : mz 329 
     Melting point (Kofler bench)&gt;260° C. 
     EXAMPLE 38 
     Synthesis of N-[3-(difluoromethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 200 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 520 mg of 3-(difluoromethoxy)aniline in place of the 2,4-difluoroaniline. 135 mg of N-[3-(difluoromethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.36 to 3.48 (m, 4 H); 3.54 to 3.65 (m, 6 H); 5.20 (broad s, 1 H); 6.88 (broad s, 2 H); 7.17 (t, J=69.0 Hz, 1 H); 7.36 (s, 1 H); 7.48 to 7.57 (m, 1 H); 10.34 (broad s, 1 H); 11.66 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.67; 
     [M+H] + : mz 381; [M−H] − : mz 379. 
     EXAMPLE 39 
     Synthesis of N-(4-fluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]propanamide 
                         
Stage 1
 
     
       
         
         
             
             
         
       
     
     88 mg of sodium hydride are added to a solution of 535 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 in 9 ml of N,N-dimethylformamide under argon. The reaction mixture is then stirred for 5 minutes at ambient temperature, and then a solution of 655 mg of di-tert-butyl dicarbonate in 2 ml of N,N-dimethylformamide is added. After stirring overnight at ambient temperature, the reaction mixture is concentrated under reduced pressure. 10 ml of water are added, followed by 1N solution of hydrochloric acid until a pH close to 6 is obtained. The resulting mixture is extracted with ethyl acetate, and the organic phase is dried over magnesium sulphate and then concentrated to dryness under reduced pressure. 735 mg of ethyl [4-({[(2-methylpropan-2-yl)oxy]carbonyl}oxy)-6-(morpholin-4-yl)pyrimidin-2-yl]acetate are obtained in the form of a yellow oil. 
     Stage 2 
     
       
         
         
             
             
         
       
     
     84 mg of sodium hydride are added to a solution of 700 mg of ethyl [4-({[(2-methylpropan-2-yl)oxy]carbonyl}oxy)-6-(morpholin-4-yl)pyrimidin-2-yl]acetate in 8 ml of N,N-dimethylformamide under argon. The reaction mixture is then stirred for 15 minutes at 0° C. 0.130 ml of methane iodide is then added and the resulting mixture is stirred at ambient temperature overnight. 0.5 ml of water is added and the reaction mixture is concentrated to dryness under reduced pressure. After purification by silica column chromatography, elution being carried out with a gradient of heptane/ethyl acetate eluent of 0% to 50% and then with ethyl acetate at 100%. 150 mg of ethyl 2-[4-({[(2-methylpropan-2-yl)oxy]carbonyl}oxy)-6-(morpholin-4-yl)pyrimidin-2-yl]propanoate are obtained in the form of a colourless oil. 
     Stage 3 
     
       
         
         
             
             
         
       
     
     0.190 ml of 1M sodium hydroxide is added to a solution of 145 mg of ethyl 2-[4-({[(2-methylpropan-2-yl)oxy]carbonyl}oxy)-6-(morpholin-4-yl)pyrimidin-2-yl]propanoate in 5 ml of tetrahydrofuran. After stirring overnight at ambient temperature, the reaction mixture is concentrated to dryness under reduced pressure. 100 mg of sodium 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]propanoate are obtained in the form of a solid which is used as it is in the subsequent stage. 
     Stage 4 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 100 mg of sodium 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]propanoate and 195 mg of 4-fluoro-3-methoxyaniline in place of the 2,4-difluoroaniline. 30 mg of N-(4-fluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]propanamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.44 (d, J=7.1 Hz, 3 H); 3.36 to 3.47 (m, 4 H); 3.50 to 3.65 (m, 4 H); 3.71 (q, J=6.8 Hz, 1 H); 3.79 (s, 3 H); 5.19 (broad s, 1 H); 7.01 to 7.18 (m, 2 H); 7.47 (dd, J=2.0 and 7.8 Hz, 1 H); 10.00 (s, 1 H); 11.55 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.65 
     [M+H] + : mz 377; [M−H] − : mz 375. 
     EXAMPLE 40 
     Synthesis of N-(2,3-dimethylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 242 mg of 2,3-dimethylaniline in place of the 2,4-difluoroaniline. 190 mg of N-(2,3-dimethylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 2.08 (s, 3 H); 2.24 (s, 3 H); 3.41 to 3.47 (m, 4 H); 3.58 to 3.65 (m, 6 H); 5.20 (s, 1 H); 6.99 to 7.08 (m, 2 H); 7.13 (d, J=7.6 Hz, 1 H); 9.57 (s, 1 H); 11.67 (broad s, 1H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.62 
     [M+H] + : mz 343; [M−H] − : mz 341. 
     EXAMPLE 41 
     Synthesis of N-(2-fluoro-3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 250 mg of 2-fluoro-3-methylaniline in place of the 2,4-difluoroaniline. 208 mg of N-(2-fluoro-3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 2.24 (broad s, 3 H); 3.37 to 3.48 (m, 4 H); 3.56 to 3.72 (m, 6 H); 5.20 (broad s, 1 H); 6.97 to 7.08 (m, 2 H); 7.71 (broad s, 1 H); 9.89 (broad s, 1 H); 11.66 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.65 
     [M+H] + : mz 347; [M−H] − : mz 345. 
     EXAMPLE 42 
     Synthesis of N-(1,3-benzoxazol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 268 mg of 1,3-benzoxazol-4-amine in place of the 2,4-difluoroaniline. 193 mg of N-(1,3-benzoxazol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of an ecru solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.43 to 3.48 (m, 4 H); 3.62 (t, J=4.9 Hz, 4 H); 3.80 (s, 2H); 5.21 (s, 1 H); 7.36 to 7.42 (m, 1 H); 7.49 (d, J=8.3 Hz, 1 H); 8.08 (d, J=7.8 Hz, 1 H); 8.78 (s, 1 H); 10.44 (broad s, 1 H); 11.73 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.55 
     [M+H] + : mz 356; [M−H] − : mz 354. 
     EXAMPLE 43 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(trifluoromethoxy)phenyl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 270 mg of 3-(trifluoromethoxy)aniline in place of the 2,4-difluoroaniline. 230 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(trifluoromethoxy)phenyl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.37 to 3.44 (m, 4 H); 3.54 to 3.64 (m, 6 H); 5.20 (s, 1H); 7.05 (d, J=6.6 Hz, 1 H); 7.41 to 7.48 (m, 2 H); 7.74 (s, 1 H); 10.45 (broad s, 1 H); 11.66 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.78; 
     [M+H] + : mz 399; [M−H] − : mz 397. 
     EXAMPLE 44 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(propan-2-yloxy)phenyl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 572 mg of 3-isopropoxyaniline in place of the 2,4-difluoroaniline. 228 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(propan-2-yloxy)phenyl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.35 (t, J=5.0 Hz, 4 H); 3.56 (t, J=4.9 Hz, 4 H); 4.25 (s, 2 H); 5.25 (broad s, 1 H); 7.31 to 7.40 (m, 2 H); 7.62 to 7.74 (m, 2 H); 11.92 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.60; 
     [M+H] + : mz 313; [M−H] − : mz 311. 
     EXAMPLE 45 
     Synthesis of N-(4-fluoro-2-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 460 mg of 4-fluoro-2-methoxyaniline in place of the 2,4-difluoroaniline. 245 mg of N-(4-fluoro-2-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a pinkish solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.43 (m, 4 H); 3.62 (m, 4 H); 3.67 (s, 2 H); 3.85 (s, 3 H); 5.20 (s, 1 H); 6.74 (dt, J=2.8 and 8.6 Hz, 1 H); 6.98 (dd, J=2.8 and 10.9 Hz, 1 H); 7.88 (dd, J=6.7 and 8.6 Hz, 1 H); 9.44 (s, 1 H); 11.67 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0,62; 
     [M+H] + : mz 363; [M−H] − : mz 361. 
     EXAMPLE 46 
     Synthesis of 2-methylpropan-2-yl {2-[3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)phenyl]ethyl}-carbamate 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 930 mg of 2-methylpropan-2-yl [2-(3-aminophenyl)ethyl]carbamate in place of the 2,4-difluoroaniline. 285 mg of 2-methylpropan-2-yl {2-[3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)phenyl]ethyl}carbamate are obtained in the form of a pinkish solid, the characteristics of which are the following: 
       1 H NMR spectrum: 1.36 (s, 9 H); 2.61 to 2.68 (m, 2 H); 3.04 to 3.14 (m, 2 H); 3.41 m, 4 H); 3.56 to 3.63 (m, 6 H); 5.20 (s, 1 H); 6.84 (broad t, J=6.7 Hz, 1H); 6.89 (d, J=8.1 Hz, 1 H); 7.22 (t, J=8.1 Hz, 1 H); 7.36 to 7.44 (m, 2 H); 10.09 (broad s, 1 H); 11.63 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.75; 
     [M+H] + : mz 458; [M−H] − : mz 456 
     Melting point=194° C. 
     EXAMPLE 47 
     Synthesis of N-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 358 mg of 4-fluoro-3-(trifluoromethyl)aniline in place of the 2,4-difluoroaniline. 222 mg of N-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.39 to 3.42 (m, 4 H); 3.57 to 3.61 (m, 4 H); 3.62 (s, 2 H); 5.21 (s, 1 H); 7.49 (t, J=9.8 Hz, 1 H); 7.75 to 7.83 (m, 1 H); 8.06 (dd, J=2.4 and 6.4 Hz, 1 H); 10.53 (broad s, 1 H); 11.68 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.77; 
     [M+H] + : mz 401; [M−H] − : mz 399. 
     EXAMPLE 48 
     Synthesis of N-(3-ethynylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 201 mg of 3-aminophenylacetylene in place of the 2,4-difluoroaniline. 190 mg of N-(3-ethynylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.39 to 3.44 (m, 4 H); 3.58 to 3.64 (m, 6 H); 4.16 (s, 1 H); 5.20 (s, 1 H); 7.17 (d, J=7.8 Hz, 1 H); 7.33 (t, J=7.8 Hz, 1 H); 7.54 (d, J=7.8Hz, 1 H); 7.75 (s, 1 H); 10.27 (s, 1 H); 11.66 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.64; 
     [M+H] + : mz 339; [M−H] − : mz 337. 
     EXAMPLE 49 
     Synthesis of N-[3-(cyclopentyloxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 354 mg of 3-(cyclopentyloxy)aniline in place of the 2,4-difluoroaniline. 269 mg of N-[3-(cyclopentyloxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 1.50 to 1.75 (m, 6 H); 1.83 to 1.96 (m, 2 H); 3.39 to 3.44 (m, 4 H); 3.54 to 3.63 (m, 6 H); 4.73 (m, 1 H); 5.20 (s, 1 H); 6.60 (dd, J=2.0 and 8.3 Hz, 1 H); 7.03 (broad d, J=8.3 Hz, 1 H); 7.18 (t, J=8.3 Hz, 1 H); 7.26 (t, J=2.2 Hz, 1 H); 10.10 (s, 1H); 11.64 (broad s, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.84; 
     [M+H] + : mz 399; [M−H] − : mz 397. 
     EXAMPLE 50 
     Synthesis of N-(4-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide (VAC.SON4.056.1) 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 500 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 815 mg of 2-amino-5-fluorophenol in place of the 2,4-difluoroaniline. After purification by silica column chromatography, eluent: CH 2 Cl 2 /MeOH 955, 149 mg of N-(4-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a grey solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.41 to 3.47 (m, 4 H); 3.59 to 3.64 (m, 4 H); 3.67 (s, 2 H); 5.20 (s, 1 H); 6.58 (dt, J=2.8 and 8.8 Hz, 1 H); 6.66 (dd, J=2.8 and 10.4 Hz, 1 H); 7.80 (dd, J=6.4 and 8.8 Hz, 1 H); 8.66 to 12.13 (broad m, 3 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=2.74 
     [M+H] + : mz 349; [M−H] − : mz 347. 
     EXAMPLE 51 
     Synthesis of 2-[2-(2,3-dihydro-1 H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one (VAC. PSB2.078.6) 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 238 mg of indoline in place of the 2,4-difluoroaniline. 230 mg of 2-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a pale pink solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.17 (t, J=8.3 Hz, 2 H); 3.41 (m, 4 H); 3.60 (m, 4 H); 3.75 (s, 2 H); 4.14 (t, J=8.3 Hz, 2 H); 5.21 (s, 1 H); 7.01 (t, J=7.6 Hz, 1 H); 7.16 (t, J=7.6 Hz, 1 H); 7.25 (d, J=7.6 Hz, 1 H); 8.02 (d, J=7.6 Hz, 1 H); 11.61 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.64 
     [M+H] + : mz 341; [M−H] − : mz 339. 
     EXAMPLE 52 
     Synthesis of N-(3-cyclopropyle-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide (VAC.PSB2.078.11) 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 302 mg of 3-cyclopropyle-4-fluoroaniline (prepared according to patent application US 20070185058) in place of the 2,4-difluoroaniline. 225 mg of N-(3-cyclopropyle-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a pale yellow solid, the characteristics of which are the following: 
       1 H NMR spectrum: 0.62 (m, 2 H); 0.99 (m, 2 H); 1.97 to 2.09 (m, 1 H); 3.41 (m, 4 H); 3.56 (s, 2 H); 3.58 to 3.63 (m, 4 H); 5.20 (s, 1 H); 7.07 (t, J=9.5 Hz, 1 H); 7.18 (dd, J=2.3 and 7.0 Hz, 1 H); 7.30 to 7.37 (m, 1 H); 10.11 (s, 1 H); 11.63 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.75 
     [M+H] + : mz 373; [M−H] − : mz 371. 
     EXAMPLE 53 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(2,3,4-trifluorophenyl)acetamide (VAC.PSB2.078.12) 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 294 mg of 2,3,4-trifluoroaniline in place of the 2,4-difluoroaniline. 195 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(2,3,4-trifluorophenyl)acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum: 3.43 (m, 4 H); 3.61 (m, 4 H); 3.67 (s, 2 H); 5.20 (s, 1 H); 7.24 to 7.35 (m, 1 H); 7.56 to 7.67 (m, 1 H); 10.18 (broad s, 1 H); 11.67 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.65 
     [M+H] + : mz 369; [M−H] − : mz 367. 
     EXAMPLE 54 
     Synthesis of N-[4-fluoro-3-(trifluoromethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 270 mg of 4-fluoro-3-(trifluoromethoxy)-aniline in place of the 2,4-difluoroaniline. 270 mg of N-[4-fluoro-3-(trifluoromethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.37 to 3.44 (m, 4 H); 3.55 to 3.65 (m, 6 H); 5.20 (s, 1 H); 7.40 to 7.59 (m, 2 H); 7.90 (broad d, J=6.8 Hz, 1 H); 10.48 (broad s, 1 H); 11.66 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.80 
     [M+H] + : mz 417; [M−H] − : mz 415. 
     EXAMPLE 55 
     Synthesis of N-[3-(2-hydroxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 294 mg of 2-(3-aminophenoxy)ethanol in 20 place of the 2,4-difluoroaniline. 180 mg of N-[3-(2-hydroxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a pinkish solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): For this batch, broad signals are observed, with: 3.42 (m, 4 H); 3.59 (m, 6 H); 3.70 (m, 2 H); 3.93 (m, 2 H); 4.82 (m, 1 H); 5.20 (s, 1 H); 6.64 (d, J=8.1 Hz, 1 H); 7.07 (d, J=8.1 Hz, 1 H); 7.15 to 7.23 (t, J=8.1 Hz, 1 H); 7.28 (s, 1 H); 10.12 (s, 1 H); 11.65 (s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.46 
     [M+H] + : mz 375; [M−H] − : mz 373. 
     EXAMPLE 56 
     Synthesis of N-(3-iodophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 268 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 324 mg of 3-iodoaniline in place of the 2,4-difluoroaniline. 345 mg of N-(3-iodophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.41 (m, 4 H); 3.58 to 3.64 (m, 6 H); 5.20 (s, 1 H); 7.12 (t, J=8.1 Hz, 1 H); 7.42 (d, J=8.1 Hz, 1 H); 7.50 (d, J=8.1 Hz, 1 H); 8.06 (s, 1 H); 10.26 (broad s, 1 H); 11.66 (broad s, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.41 
     [M+H] + : mz 441; [M−H] − : mz 439. 
     EXAMPLE 57 
     Synthesis of methyl 2-fluoro-5-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 500 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 466 mg of methyl 5-amino-2-fluorobenzoate in place of the 2,4-difluoroaniline. 625 mg of methyl 2-fluoro-5-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate are obtained in the form of a pinkish solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.41 (m, 4 H); 3.57 to 3.62 (m, 6 H); 3.85 (s, 3 H); 5.20 (s, 1 H); 7.32 (dd, J=9.0 and 10.6 Hz, 1 H); 7.79 (ddd, J=2.9 and 4.1 and 9.0 Hz, 1 H); 8.15 (dd, J=2.9 and 6.4 Hz, 1 H); 10.40 (s, 1 H); 11.67 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.59 
     [M+H] + : mz 391; [M−H] − : mz 389. 
     EXAMPLE 58 
     Synthesis of N-(3-ethoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 540 mg of 3-ethoxyaniline in place of the 2,4-difluoroaniline. 235 mg of N-(3-ethoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     1.31 (t, J=7.0 Hz, 3 H); 3.41 (m, 4 H); 3.55 to 3.64 (m, 6 H); 3.98 (q, J=7.0 Hz, 2 H); 5.20 (s, 1 H); 6.62 (d, J=8.0 Hz, 1 H); 7.06 (d, J=8, 0 Hz, 1 H); 7.19 (t, J=8.0 Hz, 1 H); 7.26 (broad s, 1 H); 10.12 (broad s, 1 H); 11.64 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.66 
     [M+H] + : mz 359; [M−H] − : mz 357. 
     EXAMPLE 59 
     Synthesis of N-(2,4-difluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 318 mg of 2,4-difluoro-3-methoxyaniline in place of the 2,4-difluoroaniline. 255 mg of N-(2,4-difluoro-3-methoxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.43 (m, 4 H); 3.61 (m, 4 H); 3.66 (s, 2 H); 3.93 (s, 3 H); 5.20 (s, 1 H); 7.11 (ddd, J=2.1 and 9.0 and 10.9 Hz, 1 H); 7.50 (dt, J=5.5 and 9.0 Hz, 1 H); 10.00 (s, 1 H); 11.65 (broad s, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.01 
     [M+H] + : mz 381; [M−H] − : mz 379. 
     EXAMPLE 60 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(2,4,5-trifluorophenyl)acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 294 mg of 2,4,5-trifluoroaniline in place of the 2,4-difluoroaniline. 230 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(2,4,5-trifluorophenyl)acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.42 (m, 4 H); 3.61 (m, 4 H); 3.69 (s, 2 H); 5.20 (s, 1 H); 7.65 (dt, J=7.6 and 10.8 Hz, 1 H); 8.01 (td, J=8.0 and 12.3 Hz, 1 H); 10.18 (broad s, 1 H); 11.67 (broad s, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.10 
     [M+H] + : mz 369; [M−H] − : mz 367. 
     EXAMPLE 61 
     Synthesis of N-(3,5-dichloro-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 360 mg of 3,5-dichloro-4-fluoroaniline in place of the 2,4-difluoroaniline. 259 mg of N-(3,5-dichloro-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.41 (m, 4 H); 3.56 to 3.64 (m, 6 H); 5.21 (s, 1 H); 7.74 (d, J=6.1 Hz, 2H); 10.50 (broad s, 1 H); 11.66 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.82 
     [M+H] + : mz 401; [M−H] − : mz 399. 
     EXAMPLE 62 
     Synthesis of 2-[2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 270 mg of 3,4-dihydro-2H-1,4-benzoxazine in place of the 2,4-difluoroaniline. After purification by silica column chromatography, elution being carried out with CH 2 Cl 2 /MeOH 95/05, 150 mg of 2-[2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.36 to 3.45 (m, 4 H); 3.52 to 3.70 (m, 4 H); 3.81 to 3.95 (m, 4 H); 4.30 (m, 2 H); 5.18 (s, 1 H); 6.81 to 6.95 (m, 2 H); 6.99 to 7.16 (m, 1 H); 7.22 to 8.18 (m, 1 H); 11.59 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.62 
     [M+H] + : mz 357; [M−H] − : mz 355. 
     EXAMPLE 63 
     Synthesis of N-(4-fluoro-3-nitrophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 500 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 510 mg of 4-fluoro-3-nitroaniline in place of the 2,4-difluoroaniline. 339 mg of N-(4-fluoro-3-nitrophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.41 (m, 4 H); 3.58 to 3.62 (m, 4 H); 3.64 (s, 2 H); 5.21 (s, 1 H); 7.56 (dd, J=9.0 and 11.2 Hz, 1 H); 7.83 to 7.88 (ddd, J=2.9 and 4.0 and 9.0 Hz, 1 H); 8.47 (dd, J=2.9 and 6.8 Hz, 1 H); 10.63 (broad s, 1 H); 11.69 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.63 
     [M+H] + : mz 378; [M−H] − : mz 376. 
     EXAMPLE 64 
     Synthesis of 2-fluoro-5-(([4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl)amino)benzoic acid 
     
       
         
         
             
             
         
       
     
     0.4 ml of 2M sodium hydroxide is added to a solution of 310 mg of methyl 2-fluoro-5-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}-amino)benzoate prepared in Example 57, in 7 ml of methanol. After stirring overnight at ambient temperature, a further 0.4 ml of 2M sodium hydroxide is added and the resulting mixture is brought to reflux for 3 hours. After cooling, the reaction mixture is concentrated under reduced pressure. The evaporation residue is taken up with water. The aqueous phase is extracted with ethyl acetate and then acidified with a 1N aqueous solution of hydrochloric acid (pH=5). The insoluble material is filtered off. The filtrate is concentrated under reduced pressure and then taken up with water and a few drops of a 1N aqueous solution of hydrochloric acid. The precipitate formed is filtered off, rinsed with petroleum ether and concentrated to dryness under reduced pressure. 52 mg of 2-fluoro-5-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoic acid are obtained in the form of a pale pink solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.41 (m, 4 H); 3.60 (t, J=4.9 Hz, 6 H); 5.20 (s, 1 H); 7.24 (t, J=9.8 Hz, 1 H); 7.75 (m, 1 H); 8.06 (m, 1 H); 10.34 (broad s, 1 H); 11.67 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.46 
     [M+H] + : mz 377; [M−H] − : mz 375. 
     EXAMPLE 65 
     Synthesis of N-(5-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 1 g of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 466 mg of 2-amino-4-fluorophenol in place of the 2,4-difluoroaniline. 795 mg of 2-N-(5-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a brown solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.44 (m, 4 H); 3.59 to 3.65 (m, 4 H); 3.72 (s, 2 H); 5.21 (s, 1 H); 6.70 to 6.78 (m, 1 H); 6.81 to 6.87 (m, 1 H); 7.85 (dd, J=3.0 and 10.8 Hz, 1 H); 9.10 to 10.09 (broad m, 1 H); 10.64 to 11.96 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.55 
     [M+H] + : mz 349; [M−H] − : mz 347. 
     EXAMPLE 66 
     Synthesis of N-(2-bromo-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 260 mg of 2-bromo-4-fluoroaniline in place of the 2,4-difluoroaniline. 310 mg of N-(2-bromo-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a brown solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     For this batch, all the signals are broad, with: 3.44 (m, 4 H); 3.62 (m, 4H); 3.65 (s, 2 H); 5.20 (s, 1 H); 7.22 to 7.32 (m, 1 H); 7.58 to 7.67 (m, 2 H); 9.73 (s, 1 H); 11.68 (s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.65 
     [M+H] + : mz 411; [M−H] − : mz 409. 
     EXAMPLE 67 
     Synthesis of N-(4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     Stage 1 
     
       
         
         
             
             
         
       
     
     Added to a solution of 500 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 1 in 1.5 ml of dioxane, are 330 mg of potassium carbonate and 150 ml of methyl iodide. The reaction mixture is heated at 40° C. for 16 minutes, and then cooled to ambient temperature. The suspension is filtered through sintered glass and then rinsed with dioxane and the filtrate is concentrated under reduced pressure. The residue is purified by silica column chromatography, elution being carried out with a mixture of dichloromethane, acetonitrile and methanol (980101, 960202, then 900505 VNN). 200 mg of ethyl [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate are obtained in the form of a white solid, the characteristics of which are the following: 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.53 
     [M+H] + : mz 282; [M−H] − : mz 280. 
     Stage 2 
     
       
         
         
             
             
         
       
     
     0.135 ml of 4-fluoroaniline and 0.670 ml of a 2M solution of trimethylaluminium are added, dropwise, to a solution of 190 mg of ethyl [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate in 10 ml of toluene. After stirring for 30 minutes at ambient temperature, 10 ml of toluene are added. After stirring for 4 hours at ambient temperature, the reaction mixture is poured into water and a 1M solution of potassium phosphate is added. The precipitate is filtered through sintered glass and then rinsed with ethyl acetate. The filtrate is then washed with water and then with a saturated aqueous solution of sodium chloride. The organic phase is extracted and then dried over magnesium sulphate, filtered through sintered glass, and concentrated under reduced pressure. After purification of the residue by silica column chromatography, elution being carried out with a mixture of dichloromethane and methanol (95/05, V/V), 20 mg of N-(4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.34 (s, 3 H); 3.40 (m, 4 H); 3.58 (m, 4 H); 3.90 (s, 2 H); 5.35 (s, 1 H); 7.15 (t, J=9.0 Hz, 2 H); 7.57 (dd, J=5.1 and 9.0 Hz, 2 H); 10.25 (s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.62 
     [M+H] + : mz 347; [M−H] − : mz 345. 
     EXAMPLE 68 
     Synthesis of N-(3-chloro-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     Stage 1 
     
       
         
         
             
             
         
       
     
     2.88 ml of 2M sodium hydroxide are added to a solution of 1.62 g of ethyl [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of Example 67, in 20 ml of tetrahydrofuran. The reaction mixture is stirred for 48 hours at ambient temperature. The precipitate formed is filtered through sintered glass, washed with ethyl acetate and rinsed several times with ethyl ether. The solid obtained is then dried in a rotary evaporator. 730 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate are obtained in the form of a white solid, the characteristics of which are the following: 
     Mass spectrometry: method B 
     Retention time Tr (min)=1.67 
     [M+H] + : mz 254; [M−H] − : mz 252. 
     Stage 2 
     
       
         
         
             
             
         
       
     
     120 ml of pyridine, 182 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 210 mg of 3-chloro-4-fluoroaniline are added to a solution of 200 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate in 2.5 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature overnight and is then concentrated under reduced pressure. Water is added, followed by extraction with ethyl acetate, further washing with water, and concentration under reduced pressure. The residue obtained is washed with ethyl acetate and then rinsed with ethyl ether. 76 mg of N-(3-chloro-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a violet solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.34 (s, 3 H); 3.37 to 3.42 (m, 4 H); 3.55 to 3.60 (m, 4 H); 3.91 (s, 2 H); 5.36 (s, 1 H); 7.38 (t, J=9.0 Hz, 1 H); 7.41 to 7.47 (m, 1 H); 7.87 (dd, J=2.4 and 6.8 Hz, 1 H); 10.42 (s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.75 
     [M+H] + : mz 381; [M−H] − : mz 379 
     Melting point (Kofler bench): 248° C. 
     EXAMPLE 69 
     Synthesis of N-(3-bromophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in Example 68, using 200 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 257 mg of 3-bromoaniline. 51 mg of N-(3-bromophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.34 (s, 3 H); 3.37 to 3.42 (m, 4 H); 3.58 (m, 4 H); 3.92 (s, 2 H); 5.36 (s, 1 H); 7.19 to 7.33 (m, 2 H); 7.45 (m, 1 H); 7.91 (broad s, 1 H); 10.37 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.75 
     [M+H] + : mz 407; [M−H] − : mz 405 
     Melting point (Kofler bench): 266° C. 
     EXAMPLE 70 
     Synthesis of 2-[1-ethyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(4-fluorophenyl)acetamide 
     Stage 1 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 67, using 600 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of example 1 and 0.23 ml of ethyl iodide in place of the methyl iodide, and replacing the potassium carbonate with cesium carbonate. After purification by silica column chromatography, eluent: 960202 CH 2 Cl 2 /CH 3 CN/MeOH, 190 mg of ethyl [1-ethyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate are obtained in the form of a white solid the characteristics of which are the following: 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.59; 
     [M+H] + : mz 296; [M−H] − : mz 294 
     Purity: 86%. 
     Stage 2 
     
       
         
         
             
             
         
       
     
     0.640 ml of a 2M solution of trimethylaluminium in toluene, and then, after stirring for 40 minutes at ambient temperature, a solution of 190 mg of ethyl [1-ethyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate in 6 ml of toluene are successively added, dropwise, to a solution of 0.13 ml of 4-fluoroaniline in 4 ml of toluene. The reaction mixture is heated at 80° C. for 4 hours, cooled using an ice bath and run into water. A 1M solution of potassium sulphate and ethyl acetate are then added, and the organic phase is extracted, washed again with a 1M solution of potassium phosphate and then dried over magnesium phosphate, filtered and, finally, concentrated under reduced pressure. After purification by silica column chromatography, eluent: 980101 then 960202 CH 2 Cl 2 /CH 3 CN/MeOH, 60 mg of 2-[1-ethyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(4-fluorophenyl)acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     1.16 (t, J=7.1 Hz, 3 H); 3.39 (m, 4 H); 3.57 (m, 4 H); 3.88 (s, 2 H); 3.91 (q, J=7.1 Hz, 2 H); 5.33 (s, 1 H); 7.15 (t, J=8.9 Hz, 2 H); 7.57 (dd, J=5.0 and 8.9 Hz, 2 H); 10.26 (s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.66 
     [M+H] + : mz 361; [M−H] − : mz 359 Melting point (Kofler bench): 238° C. 
     EXAMPLE 71 
     Synthesis of N-(1 H-indol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
                         
Stage 1
 
     The product is prepared according to the procedure described in example 5, using 500 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 445 mg of 2-methylpropan-2-yl 4-amino-1 H-indole-1-carboxylate in place of the 2,4-difluoroaniline. 500 mg of 2-methylpropan-2-yl 4-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)-1H-indole-1-carboxylate are obtained in the form of a brown solid, the characteristics of which are the following: 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.88 
     [M+H] + : mz 454; [M−H] − : mz 452. 
     Step 2 
     
       
         
         
             
             
         
       
     
     0.940 ml of trifluoroacetic acid is added dropwise to a solution of 200 mg of 2-methylpropan-2-yl 4-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)-1H-indole-1-carboxylate in 8 ml of dichloromethane. After stirring at ambient temperature for 3 hours, the reaction medium is concentrated under reduced pressure, taken up with toluene and concentrated under reduced pressure. After purification by silica column chromatography, eluent: 90/10 CH 2 Cl 2 /MeOH, 48 mg of N-(1H-indol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.43 (m, 4 H); 3.60 (m, 4 H); 3.73 (s, 2 H); 5.21 (s, 1 H); 6.68 (broad s, 1 H); 7.01 (t, J=7.9 Hz, 1 H); 7.16 (d, J=7.9 Hz, 1 H); 7.30 (t, J=2.4 Hz, 1 H); 7.55 (d, J=7.9 Hz, 1 H); 9.80 (broad s, 1 H); 11.11 (broad s, 1 H); 11.67 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.48 
     [M+H] + : mz 354; [M−H] − : mz 352. 
     EXAMPLE 72 
     Synthesis of N-(4-fluorophenyl)-3-methyl-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]butanamide 
     Stage 1 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 67, using 600 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of example 1 and 0.29 ml of 2-iodopropane in place of the methyl iodide, and replacing the potassium carbonate with cesium carbonate. After purification by silica column chromatography, eluent: 900505 CH 2 Cl 2 /CH 3 CN/MeOH, 20 mg of ethyl 3-methyl-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]butanoate are obtained in the form of a white solid, the characteristics of which are the following: 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.70 
     [M+H] + : mz 310; [M−H] − : mz 308. 
     Stage 2 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 70, using 0.023 ml of 4-fluoroaniline and 36 mg of ethyl 3-methyl-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]butanoate in place of the ethyl [1-ethyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate. After purification by silica column chromatography, eluent: 940303 CH 2 Cl 2 /CH 3 CN/MeOH, 15 mg of N-(4-fluorophenyl)-3-methyl-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]butanamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     0.87 (d, J=6.6 Hz, 3 H); 0.97 (d, J=6.6 Hz, 3 H); 2.53 to 2.57 (m, 1 H); 3.24 (d, J=10.3 Hz, 1 H); 3.42 to 3.47 (m, 4 H); 3.59 to 3.65 (m, 4 H); 5.21 (s, 1 H); 7.15 (t, J=8.8 Hz, 2 H); 7.59 (dd, J=5.1 and 8.8 Hz, 2 H); 10.09 (broad s, 1 H); 11.30 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.76 
     [M+H] + : mz 375; [M−H] − : mz 373 
     Melting point (Kofler bench): 266° C. 
     EXAMPLE 73 
     Synthesis of N-[4-fluoro-3-(methoxymethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     Stage 1 
     In a round-bottomed flask, 374 mg of sodium hydride at 60% are introduced into 10 ml of tetrahydrofuran, 1g of (5-amino-2-fluorophenyl)methanol and 0.441 ml of methyl iodide. After stirring at ambient temperature for one hour, a solution of sodium chloride and diethyl ether are added. The organic phase is extracted and then washed with water until pH=7. It is then dried over magnesium sulphate, filtered, and concentrated under reduced pressure. 900 mg of 4-fluoro-3-(methoxymethyl)aniline are obtained in the form of a black oil, which is used as it is in the next stage. 
     Stage 2 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 900 mg of 4-fluoro-3-(methoxymethyl)aniline prepared previously, in place of the 2,4-difluoroaniline. 168 mg of N-[4-fluoro-3-(methoxymethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.31 (s partially masked, 3 H); 3.41 (m, 4 H); 3.59 (m, 6 H); 4.43 (s, 2H); 5.20 (s, 1 H); 7.14 (t, J=9.3 Hz, 1 H); 7.51 (m, 1 H); 7.63 (m, 1 H); 10.21 (broad s, 1 H); 11.63 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.60 
     [M+H] + : mz 377; [M−H] − : mz 375 
     Melting point (Kofler bench): 220° C. 
     EXAMPLE 74 
     Synthesis of N-(4-fluoro-3-iodophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
                         
Stage 1
 
     1 g of 4-fluoro-3-nitrobenzene solubilized in 5 ml of ethanol is added to a suspension of 1 g of iron filings in 10 ml of ethanol, 5 ml of water and 250.4 mg of ammonium chloride, brought to reflux. After refluxing for 1 hour, the reaction mixture is filtered and the organic extracts are evaporated off. The evaporation residue is taken up in a mixture of water and dichloromethane. The aqueous phase is extracted with 3 times dichloromethane. The organic extracts are combined, dried over magnesium sulphate and concentrated under reduced pressure. 840 mg of 4-fluoro-3-iodoaniline are obtained, the characteristics of which are the following: 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.60 
     [M+H] + : mz 238. 
     Stage 2 
     The product is prepared according to the procedure described in example 5, using 300 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 272 mg of 4-fluoro-3-iodoaniline. 309 mg of N-(4-fluoro-3-iodophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.42 (m, 4 H); 3.57 to 3.63 (m, 6 H); 5.21 (s, 1 H); 7.23 (t, J=8.6 Hz, 1 H); 7.52 (ddd, J=2.5 and 4.4 and 8.6 Hz, 1 H); 8.12 (dd, J=2.5 and 5.4 Hz, 1 H); 10.29 (broad s, 1 H); 11.65 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.74 
     [M+H] + : mz 459; [M−H] − : mz 457. 
     EXAMPLE 75 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 300 mg of 3-(1,1,2,2-tetrafluoroethoxy)aniline, and 300 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 2 ml of pyridine and 2 ml of N,N-dimethylformamide. 300 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydro pyrimidin-2-yl]-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     all the signals are broad, with: 3.41 (m, 4 H); 3.60 (m, 6 H); 5.20 (s, 1 H); 6.79 (t, J=52.5 Hz, 1 H); 6.94 to 7.01 (m, 1 H); 7.35 to 7.50 (m, 2 H); 7.69 (s, 1 H); 10.40 (s, 1 H); 11.66 (s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.77 
     [M+H] + : mz 431; [M−H] − : mz 429 
     Melting point (Kofler bench): 229° C. 
     EXAMPLE 76 
     Synthesis of N-[(3-(difluoromethyl)-4-fluorophenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
                         
Stage 1
 
     
       
         
         
             
             
         
       
     
     4.48 g (3.5 ml) of N-ethyl-N-(trifluoro-λ 4 -sulphanyl)ethanamine are added, at a temperature in the region of 20° C. and under argon, to a solution of 3.36 g of 2-fluoro-5-nitrobenzaldehyde in 100 ml of dichloromethane. After stirring for 3h30 at a temperature in the region of 20° C., 300 ml of a saturated aqueous solution of sodium hydrogen carbonate are slowly added. After stirring for one hour, the organic phase is washed with 40 ml of water, and then dried over anhydrous magnesium sulphate, filtered and concentrated to dryness under reduced pressure. 3.6 g of 2-(difluoromethyl)-1-fluoro-4-nitrobenzene are obtained in the form of a yellow liquid, the characteristics of which are the following: 
     Mass spectrometry: The spectra are performed by direct introduction on a Waters GCTOF apparatus (direct introduction without LC): El: [M] + . mz=191. 
     Stage 2 
     
       
         
         
             
             
         
       
     
     A solution of 2 g of 2-(difluoromethyl)-1-fluoro-4-nitrobenzene in 10 ml of acetic acid is added slowly to a suspension of 7 g of iron, in 30 ml of acetic acid at reflux, under argon. The reaction mixture is stirred for 1 hour at reflux, and then cooled to ambient temperature. 20 ml of ethyl acetate are then added and the reaction medium is filtered through Clarcel, rinsed with ethyl acetate and then concentrated to dryness under reduced pressure. The residue is taken up with 100 ml of ethyl acetate and again filtered through Clarcel and concentrated to dryness under reduced pressure. After silica column purification of the oily residue, eluent: 95/05 CH 2 Cl 2 /MeOH, 1.1 g of a mixture containing 3-(difluoromethyl)-4-fluoroaniline are obtained in the form of a brown liquid, which is used as it is in the next stage. 
     Stage 3 
     The product is prepared according to the procedure described in example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 1.1 g of 3-(difluoromethyl)-4-fluoroaniline (stage 2) and 300 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 2 ml of pyridine and 2 ml of N,N-dimethylformamide. 260 mg of N-[3-(difluoromethyl)-4-fluorophenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.41 (m, 4 H); 3.52 to 3.67 (m, 6 H); 5.21 (s, 1 H); 7.20 (t, J=54.3 Hz, 1 H); 7.34 (t, J=8.9 Hz, 1 H); 7.68 (m, 1 H); 7.90 (m, 1 H); 10.41 (s, 1 H); 11.67 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.67 
     [M+H] + : mz 383; [M−H] − : mz 381 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 77 
     Synthesis of 2,2-difluoro-N-(4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
                         
Stage 1
 
     
       
         
         
             
             
         
       
     
     350 mg of ethyl [4-({[(2-methylpropan-2-yl)oxy]carbonyl}oxy)-6-(morpholin-4-yl)pyrimidin-2-yl]acetate dissolved beforehand in 6 ml of tetrahydrofuran are added to a solution of 570 mg of potassium 1,1,1,3,3,3-hexamethyldisilazan-2-ide in 9 ml of tetrahydrofuran, placed at a temperature of 78° C. and under argon. After stirring at this temperature for 45 min, 409 mg of manganese (2+) dibromide are added. After the suspension obtained has been stirred for thirty minutes, still at a temperature of 78° C., 847 mg of N-fluoro-N-(phenylsulphonyl)benzenesulphonamide are added. After a return to a temperature in the region of 20° C., the suspension is stirred overnight. The medium is run into a saturated aqueous solution of sodium bicarbonate, and extracted with ethyl acetate, and the organic phase is washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulphate, filtered and concentrated to dryness under reduced pressure. The residue is taken up with 10 ml of methylene chloride and then the insoluble material is filtered off and washed with three times 5 ml of methylene chloride. The filtrate is concentrated to dryness under reduced pressure and, after silica column purification of the oily residue, eluent: 95/05 CH 2 Cl 2 /EtOAc, 278 mg of ethyl difluoro[4-({[(2-methylpropan-2-yl)oxy]carbonyl}oxy)-6-(morpholin-4-yl)pyrimidin-2-yl]acetate are obtained in the form of a colourless oil, the characteristics of which are the following: 
     Mass spectrometry: method A 
     Retention time Tr (min)=1.06 
     [M+Na] + : mz 426; base peak: mz 304. 
     Stage 2 
     0.756 ml of a solution of aluminium trichloride (2N) in toluene are added slowly to a solution of 0.136 ml of 4-fluoroaniline in 5 ml of toluene at a temperature of between 0° C. and 10° C. After stirring for 40 min at a temperature in the region of 20° C., 271 mg of ethyl difluoro[4-({[(2-methylpropan-2-yl)oxy]carbonyl}oxy)-6-(morpholin-4-yl)pyrimidin-2-yl]acetate solubilized in 6 ml of toluene, are slowly added. After refluxing for 2h30, the temperature returns to a temperature in the region of 20° C. and then, at 0° C., 26 ml of water and 26 ml of a molar solution of potassium dihydrogen phosphate are added and the resulting mixture is extracted with ethyl acetate. The organic phase is washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulphate, filtered and concentrated to dryness under reduced pressure. After silica column purification of the residue, eluent: 95/05 CH 2 Cl 2 /MeOH, the solid is taken up with 5 ml of dichloromethane, the mixture is heated at 40° C. for 5 min, and then the temperature is returned to a temperature in the region of 20° C. The insoluble material is spin-filter-dried, and washed by triturating, from 1 ml of dichloromethane, three times, and then dried in a vacuum bell jar. 28 mg of 2,2-difluoro-N-(4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.51 (m, 4 H); 3.58 to 3.64 (m, 4 H); 5.92 (broad s, 1 H); 7.20 (t, J=9.0 Hz, 2 H); 7.70 (dd, J=5.2 and 9.0 Hz, 2 H); 10.70 (broad s, 1 H); 11.82 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.69 
     [M+H] + : mz 369; [M−H] − : mz 367. 
     EXAMPLE 78 
     Synthesis of N-(3,4-difluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 250 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of example 68, 169 mg of 3,4-difluoroaniline, and 285 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 2 ml of pyridine and 2 ml of N,N-dimethylformamide. 180 mg of N-(3,4-difluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.33 (s, 3 H); 3.39 (m, 4 H); 3.58 (m, 4 H); 3.91 (s, 2 H); 5.36 (s, 1 H); 7.26 (m, 1 H); 7.39 (q, J=9.5 Hz, 1 H); 7.73 (ddd, J=2.2 and 7.5 and 13.0 Hz, 1 H); 10.43 (s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.69 
     [M+H] + : mz 365; [M−H] − : mz 363 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 79 
     Synthesis of 2-[2-(2,3-dihydro-1 H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3 H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 200 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of example 68, 174 mg of 2,3-dihydro-1 H-indole, and 185 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.12 ml of pyridine and 3 ml of N,N-dimethylformamide. After silica column purification, eluent: 93/07 CH 2 Cl 2 /MeOH, the solid is taken up with 4 ml of methanol and a few drops of acetone. The suspension is heated at a temperature of 80° C., filtered while hot, and then recrystallized at a temperature of 20° C. and then of 0° C. The solid is filtered off, rinsed with diethyl ether, and then dried under a vacuum bell jar. 52 mg of 2-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of white crystals, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.17 (t, J=8.4 Hz, 2 H); 3.32 (s, 3 H); 3.39 (m, 4 H); 3.58 (m, 4 H); 4.11 (s, 2 H); 4.17 (t, J=8.4 Hz, 2 H); 5.36 (s, 1 H); 7.02 (t, J=7.5 Hz, 1 H); 7.16 (t, J=7.5 Hz, 1 H); 7.26 (d, J=7.5 Hz, 1 H); 8.01 (d, J=7.5 Hz, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.68 
     [M+H] + : mz 355; [M−H] − : mz 353 
     Melting point (Kofler bench): above 250° C. 
     EXAMPLE 80 
     Synthesis of N-(3-bromo-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 200 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of example 68, 199 mg of 3-bromo-4-fluoroaniline, and 228 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 1.5 ml of pyridine and 1.5 ml of N,N-dimethylformamide. 185 mg of N-(3-bromo-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.34 (s, 3 H); 3.39 (m, 4 H); 3.58 (m, 4 H); 3.91 (s, 2 H); 5.36 (s, 1 H); 7.30 to 7.38 (t, J=8.9 Hz, 1 H); 7.48 (ddd, J=2.7 and 4.4 and 8.9 Hz, 1 H); 7.99 (dd, J=2.7 and 6.4 Hz, 1 H); 10.40 (s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.76 
     [M+H]+: mz 425; [M−H] − : mz 423 
     Melting point (Kofler bench): above 262° C. 
     EXAMPLE 81 
     Synthesis of N-[4-fluoro-3-(hydroxymethyl)phenyl]-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 250 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of example 68, 184 mg of (5-amino-2-fluorophenyl)methanol, and 285 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 2 ml of pyridine and 2 ml of N,N-dimethylformamide. 157 mg of N-[4-fluoro-3-(hydroxymethyl)phenyl]-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a grey solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.34 (s, 3 H); 3.40 (m, 4 H); 3.59 (m, 4 H); 3.90 (s, 2 H); 4.52 (d, J=5.6 Hz, 2 H); 5.27 (t, J=5.6 Hz, 1 H); 5.35 (s, 1 H); 7.08 (t, J=9.3 Hz, 1 H); 7.43 to 7.53 (m, 1 H); 7.64 (dd, J=2.7 and 6.6 Hz, 1 H); 10.23 (s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.49 
     [M+H] + : mz 377; [M−H] − : mz 375 
     Melting point (Kofler bench): above 224° C. 
     EXAMPLE 82 
     Synthesis of N-(3-cyclopropylphenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 200 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of example 68, 194 mg of 3-cyclopropylaniline (prepared according to Wallace et al. in Tetrahedron Lett. 2002, 43, 6987), and 185 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.12 ml of pyridine and 4 ml of N,N-dimethylformamide. After extractions with ethyl acetate and silica column purification of the residue obtained, eluent: 95/05 CH 2 Cl 2 /MeOH, 129 mg of N-(3-cyclopropylphenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     0.57 to 0.64 (m, 2 H); 0.90 to 0.98 (m, 2 H); 1.82 to 1.91 (m, 1 H); 3.33 (s, 3 H); 3.38 to 3.43 (m, 4 H); 3.57 to 3.62 (m, 4 H); 3.89 (s, 2 H); 5.35 (s, 1 H); 6.79 (broad d, J=7.8 Hz, 1 H); 7.17 (t, J=7.8 Hz, 1 H); 7.28 (t, J=1.5 Hz, 1 H); 7.31 (broad d, J=7.8 Hz, 1 H); 10.11 (s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.76 
     [M+H] + : mz 369; [M−H] − : mz 367 
     Melting point (Kofler bench): 216° C. 
     EXAMPLE 83 
     Synthesis of N-(4-fluoro-3-methoxyphenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 200 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of example 68, 205 mg of 4-fluoro-3-methoxyaniline, and 185 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.12 ml of pyridine and 3 ml of N,N-dimethylformamide. After extractions with ethyl acetate and silica column purification of the residue obtained, eluent: 95/05 then 90/10 CH 2 Cl 2 /MeOH, 42 mg of N-(4-fluoro-3-methoxyphenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.34 (s, 3 H); 3.38 to 3.42 (m, 4 H); 3.55 to 3.62 (m, 4 H); 3.79 (s, 3 H); 3.90 (s, 2 H); 5.35 (s, 1 H); 7.05 (ddd, J=2.4 and 4.0 and 8.8 Hz, 1 H); 7.14 (dd, J=8.8 and 11.2 Hz, 1 H); 7.47 (dd, J=2.4 and 8.1 Hz, 1 H); 10.26 (s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.64 
     [M+H] + : mz 377; [M−H] − : mz 375 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 84 
     Synthesis of N-(1-benzofur-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 178 mg of 1-benzofuran-4-amine, and 300 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 2 ml of pyridine and 3 ml of N,N-dimethylformamide. 275 mg of 2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-phenylacetamide are obtained in the form of an off-white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.43 (m, 4 H); 3.60 (m, 4 H); 3.73 (s, 2 H); 5.21 (s, 1 H); 7.12 (broad d, J=2.2 Hz, 1 H); 7.25 (t, J=8.1 Hz, 1 H); 7.35 (broad d, J=8.1 Hz, 1 H); 7.71 (d, J=8.1 Hz, 1 H); 7.94 (d, J=2.2 Hz, 1 H); 10.12 (s, 1 H); 11.70 (broad m, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=2.96 
     [M+H] + : mz 355; [M−H] − : mz 353 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 85 
     Synthesis of 2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-phenylacetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 200 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of example 68, 134 mg of aniline, and 180 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.12 ml of pyridine and 2.5 ml of N,N-dimethylformamide. 95 mg of 2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-phenylacetamide are obtained in the form of a purple solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.35 (s, 3 H); 3.41 (m, 4 H); 3.58 (m, 4 H); 3.91 (s, 2 H); 5.35 (s, 1 H); 7.06 (t, J=7.8 Hz, 1 H); 7.31 (t, J=7.8 Hz, 2 H); 7.55 (d, J=7.8 Hz, 2 H); 10.19 (s, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=2.87 
     [M+H] + : mz 329; [M−H] − : mz 327 
     Melting point (Kofler bench): 212° C. 
     EXAMPLE 86 
     Synthesis of N-(3-cyclopropyl-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
                         
Stage 1
 
     
       
         
         
             
             
         
       
     
     558 mg of cyclopropylboronic acid, 3.7 g of tribasic potassium phosphonate, 70 mg of tricyclohexylphosphane and 56 mg of palladium(2+) diacetate in 1.5 ml of water are added to a solution of 950 mg of 3-bromo-4-fluoroaniline in 20 ml of toluene, with stirring and under argon. The mixture is degassed and then heated to a temperature of 100° C. After 15 hours, the reaction medium is cooled to a temperature in the region of 20° C., run into 100 ml of water, and then extracted with four times 60 ml of diethyl ether. The combined organic phases are dried over anhydrous magnesium sulphate, filtered and concentrated under reduced pressure. The residue is purified on a silica column, eluent: 7030 cyclohexaneethyl acetate. 494 mg of 3-cyclopropyl-4-fluoroaniline are obtained in the form of a brown oil, the characteristics of which are the following: 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.40 
     [M+H] + : mz 152; 
                         
Stage 2
 
     The product is prepared according to the procedure described in example 5, using 200 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of example 68, 220 mg of 3-cyclopropyl-4-fluoroaniline, and 180 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.12 ml of pyridine and 2.5 ml of N,N-dimethylformamide. After extractions with ethyl acetate and silica column purification, eluent 90/10 CH 2 Cl 2 /MeOH, the residue is taken up with ml of diisopropyl ether, and the precipitate is spin-filter-dried and dried under vacuum, so as to obtain 69 mg of N-(3-cyclopropyl-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide in the form of a yellow solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     0.57 to 0.66 (m, 2 H); 0.94 to 1.03 (m, 2 H); 1.93 to 2.08 (m, 1 H); 3.33 (s, 3 H); 3.37 to 3.42 (m, 4 H); 3.55 to 3.62 (m, 4 H); 3.87 (s, 2 H); 5.35 (s, 1 H); 7.07 (dd, J=8.8 and 10.3 Hz, 1 H); 7.16 (dd, J=2.6 and 7.0 Hz, 1 H); 7.29 to 7.38 (m, 1 H); 10.16 (s, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.53 
     [M+H] + : mz 387; [M−H] − : mz 385 
     Melting point (Kofler bench): 245° C. 
     EXAMPLE 87 
     Synthesis of N-(3-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 500 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 357 mg of 2-amino-6-fluorophenol, and 600 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 4 ml of pyridine and 4 ml of N,N-dimethylformamide. 335 mg of N-(3-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a beige solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.44 (m, 4 H); 3.62 (m, 4 H); 3.71 (s, 2 H); 5.21 (s, 1 H); 6.78 (dt, J=6.0 and 8.1 Hz, 1 H); 6.94 (broad t, J=8.1 Hz, 1 H); 7.64 (broad d, J=8.1 Hz, 1 H); 9.55 to 10.10 (broad m, 2 H); 11.69 (broad m, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=2.66 
     [M+H] + : mz 349; [M−H] − : mz 347 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 88 
     Synthesis of 2-[2-(4-fluoro-2,3-dihydro-1 H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3 H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 274 mg of 4-fluoro-2,3-dihydro-1 H-indole, and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.16 ml of pyridine and 4 ml of N,N-dimethylformamide. 249 mg of 2-[2-(4-fluoro-2,3-dihydro-1 H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3 H)-one are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.20 (t, J=8.4 Hz, 2 H); 3.41 (m, 4 H); 3.61 (m, 4 H); 3.76 (s, 2 H); 4.21 (t, J=8.4 Hz, 2 H); 5.21 (s, 1 H); 6.86 (t, J=8.6 Hz, 1 H); 7.12 to 7.31 (m, 1 H); 7.84 (d, J=8.1 Hz, 1 H); 11.61 (broad s, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.20 
     [M+H] + : mz 359; [M−H] − : mz 357 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 89 
     Synthesis of 2-[2-(4-chloro-2,3-dihydro-1 H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3 H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 307 mg of 4-chloro-2,3-dihydro-1H-indole, and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.16 ml of pyridine and 4 ml of N,N-dimethylformamide. 247 mg of 2-[2-(4-chloro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.18 (t, J=8.4 Hz, 2 H); 3.41 (m, 4 H); 3.60 (m, 4 H); 3.76 (s, 2 H); 4.20 (t, J=8.4 Hz, 2 H); 5.21 (s, 1 H); 7.09 (d, J=8.1 Hz, 1 H); 7.22 (t, J=8.1 Hz, 1 H); 7.97 (d, J=8.1 Hz, 1 H); 11.62 (broad s, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.46; 
     [M+H] + : mz 375; [M−H] − : mz 373 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 90 
     Synthesis of N-(3-ethynyl-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
                         
Stage 1
 
     
       
         
         
             
             
         
       
     
     1.126 ml of ethynyl(trimethyl)silane, 55 mg of triphenylphosphine and 24 mg of palladium (2+) acetate are added to a solution of 1.169 g of 2-bromo-1-fluoro-4-nitrobenzene in 13 ml of triethylamine with stirring and under argon. After four and a half hours at a temperature of 100° C., the reaction medium is cooled and the insoluble material is filtered off through sintered glass. The filtrate is concentrated to dryness under reduced pressure. After two silica column purifications, eluent: 90/10 heptane/EtOAc then 955 heptane/EtOAc, 460 mg of [(2-fluoro-5-nitrophenyl)ethynyl](trimethyl)silane are obtained in the form of a yellow solid, the characteristics of which are the following: 
     Mass spectrometry: The spectra were performed by direct introduction on a Waters GCTOF apparatus (direct introduction without LC): 
     El: [M] + . mz 237; base peak: mz 222. 
     Stage 2 
     
       
         
         
             
             
         
       
     
     460 mg of iron are added to a solution of 460 mg of [(2-fluoro-5-nitrophenyl)ethynyl](trimethyl)silane in 10 ml of methanol, and the medium is adjusted to pH 4-5 with concentrated hydrochloric acid. After refluxing for three and a half hours, the medium is cooled and then filtered through silica, and concentrated to dryness under reduced pressure. The residue is taken up with diethyl ether, the insoluble material is filtered off, and then the filtrate is concentrated to dryness under reduced pressure. 370 mg of 4-fluoro-3-[(trimethylsilyl)ethynyl]aniline are obtained in the form of an orangey oil, the characteristics of which are the following: 
     Mass spectrometry: method A 
     Retention time Tr (min)=1.11 
     [M+H] + : mz 208; base peak: mz 249. 
     Stage 3 
     
       
         
         
             
             
         
       
     
     16 mg of potassium carbonate are added to a solution of 360 mg of 4-fluoro-3-[(trimethylsilyl)ethynyl]aniline in 5 ml of methanol. After stirring over night under argon and at a temperature in the region of 20° C., the medium is concentrated to dryness under reduced pressure, then taken up in 8 ml of water and neutralized with a few drops of hydrochloric acid (1 N), and then extracted three times with diethyl ether. The combined organic phases are dried over anhydrous magnesium sulphate, filtered and concentrated to dryness under reduced pressure. 225 mg of 3-ethynyl-4-fluoroaniline are obtained in the form of a brown oil, the characteristics of which are the following: 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.49 
     [M+H] + : mz 136; 
     Stage 4 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 204 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 211 mg of 3-ethynyl-4-fluoroaniline, and 195 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.126 ml of pyridine and 3 ml of N,N-dimethylformamide. 200 mg of N-(3-ethynyl-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.41 (m, 4 H); 3.60 (m, 6 H); 4.48 (s, 1 H); 5.20 (s, 1 H); 7.27 (t, J=9.0 Hz, 1 H); 7.56 (m, 1 H); 7.78 (dd, J=1.5 and 5.9 Hz, 1 H); 10.31 (broad m, 1 H); 11.66 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.75 
     [M+H] + : mz 357; [M−H] − : mz 355 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 91 
     Synthesis of 2-[2-(4-hydroxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 270 mg of 2,3-dihydro-1H-indol-4-ol, and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.16 ml of pyridine and 4 ml of N,N-dimethylformamide. 205 mg of 2-[2-(4-hydroxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a pink solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.01 (t, J=8.1 Hz, 2 H); 3.41 (m, 4 H); 3.61 (m, 4 H); 3.71 (s, 2 H); 4.12 (t, J=8.1 Hz, 2 H); 5.20 (s, 1 H); 6.49 (d, J=8.1 Hz, 1 H); 6.97 (t, J=8.1 Hz, 1 H); 7.50 (d, J=8.1 Hz, 1 H); 9.44 (broad s, 1 H); 11.60 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.57 
     [M+H] + : mz 357; [M−H] − : mz 355 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 92 
     Synthesis of 2-[2-(4,6-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 310 mg of 4,6-difluoro-2,3-dihydro-1H-indole, and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.16 ml of pyridine and 4 ml of N,N-dimethylformamide. 225 mg of 2-[2-(4,6-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.17 (t, J=8.4 Hz, 2 H); 3.41 (m, 4 H); 3.61 (m, 4 H); 3.78 (s, 2 H); 4.24 (t, J=8.4 Hz, 2 H); 5.21 (s, 1 H); 6.89 (broad t, J=8.9 Hz, 1 H); 7.64 (broad d, J=8.9 Hz, 1 H); 11.62 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.73 
     [M+H] + : mz 377; [M−H] − : mz 375 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 93 
     Synthesis of N-(3-iodo-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 68, using 200 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 210 mg of 3-iodo-4-fluoroaniline. 186 mg of N-(3-iodo-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.33 (s, 3 H); 3.40 (m, 4 H); 3.58 (m, 4H); 3.90 (s, 2 H); 5.36 (s, 1 H); 7.22 (t, J=8.4 Hz, 1 H); 7.49 (m, 1 H); 8.11 (dd, J=2.4 and 5.6 Hz, 1 H); 10.33 (broad m, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.50; 
     [M+H] + : mz 473; [M−H] − : mz 471. 
     EXAMPLE 94 
     Synthesis of 2-[2-(4,5-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, but using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, 383 mg of 4,5-difluoro-2,3-dihydro-1H-indole hydrochloride, and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.32 ml of pyridine and 4 ml of N,N-dimethylformamide. 210 mg of 2-[2-(4,5-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a pale pink, powdery solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.25 (t, J=8.3 Hz, 2 H); 3.41 (m, 4 H); 3.61 (m, 4 H); 3.76 (s, 2 H); 4.23 (t, J=8.3 Hz, 2 H); 5.21 (s, 1 H); 7.05 to 7.34 (m, 1 H); 7.79 (dd, J=3.4 and 8.8 Hz, 1 H); 11.60 (broad m, 1 H) Mass spectrometry: method B 
     Retention time Tr (min)=3.30; 
     [M+H] + : mz 377; [M−H] − : mz 375 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 95 
     Synthesis of 2-[2-(6-fluoro-2,3-dihydro-′1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, but using 200 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, 210 mg of 6-fluoro-2,3-dihydro-1H-indole, and 194 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.12 ml of pyridine and 3 ml of N, N-dimethylformamide. 184 mg of 2-[2-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.14 (t, J=8.3 Hz, 2 H); 3.37 to 3.45 (m, 4 H); 3.54 to 3.64 (m, 4 H); 3.76 (s, 2 H); 4.19 (t, J=8.3 Hz, 2 H); 5.21 (s, 1 H); 6.83 (dt, J=2.0 and 8.6 Hz, 1 H); 7.19 to 7.31 (m, 1 H); 7.77 (dd, J=2.6 and 10.8 Hz, 1 H); 11.61 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.67; 
     [M+H] + : mz 359; [M−H] − : mz 357 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 96 
     Synthesis of 2-[2-(2-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 500 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 510 mg of 2-methyl-2,3-dihydro-1H-indole, and 487 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.308 ml of pyridine and 8 ml of N,N-dimethylformamide. 400 mg of 2-[2-(2-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     1.26 (d, J=6.1 Hz, 3 H); 2.65 to 2.72 (m, 1 H); 3.18 to 3.44 (m partially masked, 5H); 3.54 to 3.63 (m, 4 H); 3.72 (d, J=15.7 Hz, 1 H); 3.92 (d, J=15.7 Hz, 1 H); 4.71 (m, 1 H); 5.20 (s, 1 H); 7.04 (t, J=7.8 Hz, 1 H); 7.18 (t, J=7.8 Hz, 1 H); 7.29 (d, J=7.8 Hz, 1 H); 7.96 (d, J=7.8 Hz, 1 H); 11.69 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.70; 
     [M+H] + : mz 355; [M−H] − : mz 353 
     Melting point (Kofler bench): 172° C. 
     EXAMPLE 97 
     Synthesis of N-[3-(difluoromethyl)-4-fluorophenyl]-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, but using 275 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of example 68, 322 mg of 3-(difluoromethyl)-4-fluoroaniline (example 76, stage 2), and 250 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.16 ml of pyridine and 4 ml of N,N-dimethylformamide. 98 mg of N-[3-(difluoromethyl)-4-fluorophenyl]-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 
     3.34 (s, 3 H); 3.39 (m, 4 H); 3.58 (m, 4 H); 3.92 (s, 2 H); 5.36 (s, 1 H); 7.20 (t, J=54.3 Hz, 1 H); 7.34 (t, J=9.5 Hz, 1 H); 7.68 (m, 1 H); 7.89 (m, 1 H); 10.45 (s, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.29; 
     [M+H] + : mz 397; [M−H] − : mz 395. 
     EXAMPLE 98 
     Synthesis of 2-(1-methyl-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(3,4,5-trifluorophenyl)acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 68, using 200 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 214 mg of 3,4,5-trifluoroaniline, and 180 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.12 ml of pyridine and 2.5 ml of N,N-dimethylformamide. 72 mg of 2-(1-methyl-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(3,4,5-trifluorophenyl)acetamide are obtained in the form of a cream solid, the characteristics of which are the following: 
       1  H NMR spectrum (400 MHz): 3.33 (s, 3 H); 3.39 (m, 4 H); 3.58 (m, 4H); 3.93 (s, 2 H); 5.36 (s, 1 H); 7.46 (dd, J=6.4 and 10.3 Hz, 2 H); 10.58 (broad s, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.47; 
     [M+H] + : mz 383; [M−H] − : mz 381 
     Melting point (Kofler bench): above 266° C. 
     EXAMPLE 99 
     Synthesis of N-(1-methyl-1H-indol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     2 ml of pyridine, 300 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 272 mg of 1-methyl-1H-indol-4-ylamine are added to a solution of 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, in 2 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 15 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 280 mg of N-(1-methyl-1H-indol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a pinkish solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.42 (m, 4 H); 3.60 (m, 4 H); 3.73 (s, 2H); 3.78 (s, 3 H); 5.21 (s, 1 H); 6.67 (d, J=2.9 Hz, 1 H); 7.08 (t, J=8.1 Hz, 1 H); 7.19 (d, J=8.1 Hz, 1 H); 7.29 (d, J=2.9 Hz, 1 H); 7.60 (d, J=8.1 Hz, 1 H); 9.85 (broad s, 1 H); 11.68 (broad m, 1 H) 
     Mass spectrometry: method 
     [M+H] + : mz 366; [M−H] − : mz 368. 
     EXAMPLE 100 
     Synthesis of 2-[2-(4-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 339 mg of 4-methylindoline hydrochloride, and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 241 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 22 mg of 2-[2-(4-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a fuchsia crystalline powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 2.21 (s, 3 H); 3.08 (t, J=8.3 Hz, 2 H); 3.42 (m, 4 H); 3.61 (m, 4 H); 3.75 (s, 2 H); 4.15 (t, J=8.3 Hz, 2 H); 5.20 (s, 1 H); 6.85 (d, J=8.0 Hz, 1 H); 7.07 (t, J=8.0 Hz, 1 H); 7.85 (d, J=8.0 Hz, 1 H); 11.62 (broad m, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.31; 
     [M+H] + : mz 355; [M−H] − : mz 353 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 101 
     Synthesis of 2-[2-(3-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 500 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 170 mg of 3-methylindoline and 487 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 310 μl of pyridine and 6.0 ml of N,N-dimethylformamide. 367 mg of 2-[2-(3-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a white crystalline powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.29 (d, J=6.8 Hz, 3 H); 3.42 (m, 4 H); 3.49 (m, 1 H); 3.60 (m, 4 H); 3.68 (dd, J=6.8 and 9.8 Hz, 1 H); 3.75 (s, 2 H); 4.33 (t, J=9.8 Hz, 1 H); 5.21 (s, 1 H); 7.04 (t, J=7.8 Hz, 1 H); 7.18 (t, J=7.8 Hz, 1 H); 7.27 (d, J=7.8 Hz, 1 H); 8.01 (d, J=7.8 Hz, 1 H); 11.62 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.73; 
     [M+H] + : mz 355; [M−H] − : mz 353 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 102 
     Synthesis of 2-[2-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 68, using 275 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 274 mg of 4-fluoroindoline and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 161 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 102 mg of 2-[2-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a pale pink powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.19 (t, J=8.4 Hz, 2 H); 3.31 (s, 3 H); 3.39 (m, 4 H); 3.57 (m, 4 H); 4.12 (s, 2 H); 4.25 (t, J=8.4 Hz, 2 H); 5.36 (s, 1 H); 6.87 (t, J=8.7 Hz, 1 H); 7.22 (m, 1 H); 7.84 (d, J=8.1 Hz, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.73; 
     [M+H] + : mz 373; [M−H] − : mz 371 
     Melting point (Kofler bench): 244° C. 
     EXAMPLE 103 
     2-[2-(5-Fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 274 mg of 5-fluoroindoline and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.16 ml of pyridine and 4 ml of dimethylformamide. 197 mg of 2-[2-(5-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one are obtained in the form of a very pale pink powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz, δ in ppm, DMSO-d 6 ): 3.18 (t, J=8.2 Hz, 2H); 3.42 (m, 4 H); 3.60 (m, 4 H); 3.74 (s, 2 H); 4.16 (t, J=8.2 Hz, 2 H); 5.20 (s, 1 H); 6.98 (broad t, J=8.9 Hz, 1 H); 7.12 (broad d, J=8.9 Hz, 1 H); 8.00 (dd, J=5.3 and 8.9 Hz, 1 H); 11.61 (broad m, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.70; 
     [M+H] + : mz 359; [M−H] − : mz 357 
     Melting point (Kofler bench): 264° C. 
     EXAMPLE 104 
     Synthesis of 2-[2-(4-chloro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 68, using 275 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 307 mg of 4-chloroindoline and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 161 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 84 mg of 2-[2-(4-chloro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a slightly pinkish powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.18 (t, J=8.4 Hz, 2 H); 3.31 (broad s, 3H); 3.39 (m, 4 H); 3.58 (m, 4 H); 4.11 (s, 2 H); 4.23 (t, J=8.4 Hz, 2 H); 5.36 (s, 1 H); 7.09 (d, J=8.1 Hz, 1 H); 7.22 (t, J=8.1 Hz, 1 H); 7.96 (d, J=8, 1 Hz, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.81; 
     [M+H] + : mz 389; [M−H] − : mz 387 
     Melting point (Kofler bench): 235° C. 
     EXAMPLE 105 
     Synthesis of N-(1-benzothiophen-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     2 ml of pyridine, 257 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 223 mg of benzo[B]thiophen-4-ylamine are added to a solution of 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, in 2 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 15 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 262 mg of N-(1-benzothiophen-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the formed of an off-white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.43 (m, 4 H); 3.60 (m, 4 H); 3.74 (s, 2H); 5.21 (s, 1 H); 7.34 (t, J=7.9 Hz, 1 H); 7.65 (d, J=5.6 Hz, 1 H); 7.71 to 7.82 (m, 3 H); 10.17 (broad m, 1 H); 11.70 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.66; 
     [M+H] + : mz 369; [M−H] − : mz 371. 
     EXAMPLE 106 
     Synthesis of 2-{2-[2-(hydroxymethyl)-2,3-dihydro-1 H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 298 mg of 2,3-dihydro-1H-indol-2-ylmethanol and 249 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 322 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 212 mg of 2-{2-[2-(hydroxymethyl)-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a pale pink crystalline powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 2.86 (d, J=16.1 Hz, 1 H); 3.25 (dd, J=8.6 and 16.1 Hz, 1 H); 3.34 to 3.43 (m, 5H); 3.51 (m, 1 H); 3.60 (m, 4 H); 3.81 (d, J=15.9 Hz, 1 H); 4.01 (d, J=15.9 Hz, 1 H); 4.64 (m, 1 H); 5.13 (broad m, 1 H); 5.20 (s, 1 H); 7.03 (t, J=7.8 Hz, 1 H); 7.16 (t, J=7.8 Hz, 1 H); 7.26 (d, J=7.8 Hz, 1 H); 7.94 (d, J=7.8 Hz, 1 H); 11.63 (broad m, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=2.80; 
     [M+H] + : mz 371; [M−H] − : mz 369 
     Melting point (Kofler bench): 200° C. 
     EXAMPLE 107 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-{2-[2-(piperidin-1-yl)ethoxy]phenyl}acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 303 mg of 2-(2-piperidin-1-ylethoxy)phenylamine and 300 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 2 ml of pyridine and 2 ml of dimethylformamide. 255 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-{2-[2-(piperidin-1-yl)ethoxy]phenyl}acetamide are obtained in the form of a beige solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.37 (m, 2 H); 1.43 to 1.53 (m, 4 H); 2.40 (m, 4 H); 2.65 (t, J=6.0 Hz, 2 H); 3.43 (m, 4 H); 3.60 (m, 4 H); 3.68 (s, 2H); 4.13 (t, J=6.0 Hz, 2 H); 5.22 (s, 1 H); 6.89 (m, 1 H); 7.00 to 7.13 (m, 2 H); 7.93 (d, J=8.3 Hz, 1 H); 9.30 (broad m, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=2.20; 
     [M+H] + : mz 442; [M−H] − : mz 440. 
     EXAMPLE 108 
     Synthesis of N-[2-(2-methoxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     2 ml of pyridine, 300 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 303 mg of 2-(2-methoxyethoxy)phenylamine are added to a solution of 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, in 2 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 15 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 223 mg of N-[2-(2-methoxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a pinkish solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.19 to 3.33 (s partially masked, 3 H); 3.43 (m, 4H); 3.61 (m, 4 H); 3.67 to 3.72 (m, 4 H); 4.16 (t, J=4.5 Hz, 2 H); 5.21 (s, 1 H); 6.94 (m, 1 H); 7.02 to 7.13 (m, 2 H); 7.95 (d, J=8.1 Hz, 1 H); 9.25 (broad s, 1 H); 11.67 (broad m, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.00; 
     [M+H] + : mz 387; [M−H] − : mz 389. 
     EXAMPLE 109 
     Synthesis of 2-[2-(4-hydroxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 68, using 275 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 270 mg of indolin-4-ol and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 161 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 85 mg of 2-[2-(4-hydroxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a pink powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.01 (t, J=8.6 Hz, 2 H); 3.31 (s masked, 3 H); 3.40 (m, 4 H); 3.58 (m, 4 H); 4.07 (s, 2 H); 4.16 (t, J=8.6 Hz, 2 H); 5.36 (s, 1 H); 6.50 (d, J=8.2 Hz, 1 H); 6.97 (t, J=8.2 Hz, 1 H); 7.49 (d, J=8.2 Hz, 1 H); 9.47 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.49; 
     [M+H] + : mz 371; [M−H] − : mz 369 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 110 
     Synthesis of 2-[2-(4-methoxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 68, using 275 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 298 mg of 4-methoxyindoline and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 161 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 107 mg of 2-[2-(4-methoxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a salmon pink powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.04 (t, J=8.5 Hz, 2 H); 3.31 (s masked, 3 H); 3.40 (m, 4 H); 3.59 (m, 4 H); 3.80 (s, 3 H); 4.09 (s, 2 H); 4.18 (t, J=8.5 Hz, 2 H); 5.36 (s, 1 H); 6.71 (d, J=8.2 Hz, 1 H); 7.15 (t, J=8.2 Hz, 1 H); 7.64 (d, J=8.2 Hz, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.69; 
     [M+H] + : mz 385 
     Melting point (Kofler bench): 229° C. 
     EXAMPLE 111 
     Synthesis of 2-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 70, using 304 μl of 1,2,3,4-tetrahydroisoquinoline, 300 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of example 1 and 1.3 ml of a 2M solution of trimethylaluminium, in a mixture of 21 ml of touene and 10 ml of tetrahydrofuran. 130 mg of 2-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are thus obtained in the form of a whitish foam, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): for this batch, all the signals are broad, with: 2.86 (m, 2 H); 3.33 (m, 4 H); 3.56 (m, 4 H); 3.72 (m, 4 H); 4.67 (s, 2 H); 5.13 (s, 1 H); 7.18 (s, 4 H); 11.23 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.62; 
     [M+H] + : mz 355; [M−H] − : mz 353 
     Melting point (Kofler bench): 107.5° C. 
     EXAMPLE 112 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]l-N-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}acetamide 
     
       
         
         
             
             
         
       
     
     2 ml of pyridine, 300 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 273 mg of 2-(2-pyrrolidin-1-yl-ethoxy)phenylamine are added to a solution of 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, in 2 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 2 hours, and then concentrated under reduced pressure. 
     After silica column purification, elution being carried out with a mixture of dichloromethane and methanol (95/05 by volume), 45 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.71 (m, 4 H); 2.60 (broad m, 4 H); 2.84 (broad m, 2H); 3.43 (m, 4 H); 3.61 (m, 4 H); 3.67 (s, 2 H); 4.16 (t, J=5.9 Hz, 2H); 5.22 (s, 1 H); 6.93 (m, 1 H); 7.03 to 7.13 (m, 2 H); 7.94 (d, J=8.1 Hz, 1 H); 9.46 (broad s, 1 H); 13.33 (very broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.39; 
     [M+H] + : mz 426; [M−H] − : mz 428. 
     EXAMPLE 113 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[2-(pyridin-3-ylmethoxy)phenyl]acetamide 
     
       
         
         
             
             
         
       
     
     2 ml of pyridine, 300 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 366 mg of 2-(pyridin-3-ylmethoxy)phenylamine are added to a solution of 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, in 2 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 20 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 150 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[2-(pyridin-3-ylmethoxy)phenyl]acetamide are obtained in the form of a brown solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): all the signals are broad, with: 3.37 (m, 4 H); 3.55 (m, 4 H); 3.70 (s, 2 H); 5.19 (s, 1 H); 5.26 (s, 2 H); 6.93 (t, J=7.6 Hz, 1 H); 7.07 (t, J=7.6 Hz, 1 H); 7.14 (d, J=7.6 Hz, 1 H); 7.40 (m, 1 H); 7.88 (m, 2 H); 8.53 (d, J=5.2 Hz, 1 H); 8.70 (s, 1 H); 9.47 (s, 1 H); 11.66 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.44; 
     [M+H]+: mz 420; [M−H] − : mz 422. 
     EXAMPLE 114 
     Synthesis of 3-methyl-2-[2-(4-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 68, using 275 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 339 mg of 4-methylindoline hydrochloride and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 240 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 93 mg of 3-methyl-2-[2-(4-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a pink powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 2.21 (s, 3 H); 3.08 (t, J=8.3 Hz, 2 H); 3.29 (s, 3 H); 3.41 (m, 4 H); 3.58 (m, 4 H); 4.10 (s, 2 H); 4.19 (t, J=8.3 Hz, 2H); 5.36 (s, 1 H); 6.86 (d, J=8.1 Hz, 1 H) 7.07 (t, J=8.1 Hz, 1 H); 7.84 (d, J=8.1 Hz, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.75; 
     [M+H] + : mz 369; [M−H] − : mz 367 
     Melting point (Kofler bench): 239° C. 
     EXAMPLE 115 
     Synthesis of 2-[2-(3-dimethylaminomethyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one 
                         
Stage 1
 
     
       
         
         
             
             
         
       
     
     1.1 g of sodium cyanoborohydride is gradually added to a solution of 1 g of gramine in 20 ml of trifluoroacetic acid, under argon, cooled in an ice bath, and stirred for half an hour at 0° C. and then for 2 h at ambient temperature. The reaction medium is plunged into 50 g of ice and alkalinized using 30% sodium hydroxide, and is then extracted with four times 30 ml of ethyl acetate. The organic phase is washed with 20 ml of water, dried over anhydrous magnesium sulphate, filtered, and then concentrated to dryness under reduced pressure. After a silica column purification, eluent: 85/15 v/v CH 2 Cl 2 /MeOH, 660 mg of (2,3-dihydro-1H-indol-3-ylmethyl)dimethylamine are obtained in the form of a yellow solid, the characteristics of which are the following: 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.16; mixture with that expected 
     [M+H] + : mz 177. 
     Stage 2 
     The product is prepared according to the procedure described in example 5, using 220 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 300 mg of (2,3-dihydro-1H-indol-3-ylmethyl)dimethylamine and 210 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.14 ml of pyridine and 2.5 ml of N,N-dimethylformamide. 206 mg of 2-[2-(3-dimethylaminomethyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one are obtained in the form of a pink solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 2.22 (s, 6 H); 2.35 (m, 1 H); 2.45 (m, 1 H); 3.28 (m masked, 1 H); 3.41 (m, 4 H); 3.60 (m, 4 H); 3.76 (m, 2 H); 3.91 (dd, J=5.7 and 9.9 Hz, 1 H); 4.23 (t, J=9.9 Hz, 1 H); 5.21 (s, 1 H); 7.02 (t, J=8.1 Hz, 1 H); 7.19 (t, J=8.1 Hz, 1 H); 7.29 (d, J=8.1 Hz, 1 H); 8.02 (d, J=8.1 Hz, 1 H); 11.61 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.37; 
     [M+H] + : mz 398; [M+2 H] 2+ : mz 199.5 (base peak) 
     [M−H] − : m/z 396; 
     Melting point (Kofler bench): 243° C. 
     EXAMPLE 116 
     Synthesis of 2-[2-(4-bromo-2,3-dihydro-1 H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 68, using 275 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 352 mg of 4-bromoindoline hydrochloride and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 201 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 161 mg of 2-[2-(4-bromo-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3 H)-one are obtained in the form of a pink powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.14 (t, J=8.3 Hz, 2 H); 3.30 (s masked, 3 H); 3.39 (m, 4 H); 3.58 (m, 4 H); 4.11 (s, 2 H); 4.22 (t, J=8.3 Hz, 2 H); 5.36 (s, 1 H); 7.14 (t, J=7.8 Hz, 1 H); 7.24 (d, J=7.8 Hz, 1 H); 8.01 (d, J=7.8 Hz, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.83; 
     [M+H] + : mz 431; [M−H] − : mz 433 
     Melting point (Kofler bench): 226° C. 
     EXAMPLE 117 AND EXAMPLE 118 
     Separation of 2-{2-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3 H)-one and 2-{2-[(2R)-2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The products were obtained by chiral chromatographic separation of 311 mg of 2-{2-[(2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one (example 96) on a Chiralpak T304 20 μm chiral column (1080 g, 20 μm, 835 cm), eluent: acetonitrile/isopropanol: 90/10; flow rate: 185 ml/min. After purification, 160 mg of (+)-2-{2-[(2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3 H)-one are obtained, as first enantiomer, in the form of a pink amorphous solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): for this batch, the signals are broad, with: 1.26 (d, J=6.8 Hz, 3 H); 2.44 (m partially masked, 1 H); 2.69 (d, J=15.2 Hz, 1 H); 3.42 (m, 4 H); 3.60 (m, 4 H); 3.72 (d, J=15.7 Hz, 1 H); 3.92 (d, J=15.7 Hz, 1 H); 4.72 (m, 1 H); 5.20 (s, 1 H); 7.04 (t, J=7.8 Hz, 1H); 7.18 (t, J=7.8 Hz, 1 H); 7.28 (d, J=7.8 Hz, 1 H); 7.96 (d, J=7.8 Hz, 1 H); 11.67 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.70; 
     [M+H] + : mz 355; [M−H] − : mz 353; 
     Optical rotation: α D =+65.0°+/−1.3 (c=1.736 mg in 0.5 mL of methanol); 
     Then the second enantiomer, i.e.: 143 mg of (−)-2-{2-[(2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one, is obtained in the form of a white amorphous solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): for this batch, the signals are broad, with: 1.26 (d, J=6.8 Hz, 3 H); 2.45 (m partially masked, 1 H); 2.69 (m, 1 H); 3.41 (m, 4 H); 3.61 (m, 4 H); 3.72 (d, J=15.7 Hz, 1 H); 3.92 (d, J=15.7 Hz, 1 H); 4.70 (m, 1 H); 5.20 (s, 1 H); 7.04 (t, J=7.8 Hz, 1 H); 7.18 (t, J=7.8 Hz, 1 H); 7.28 (d, J=7.8 Hz, 1 H); 7.96 (d, J=7.8 Hz, 1 H); 11.64 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.70; 
     [M+H] + : mz 355; [M−H] − : mz 353; 
     Optical rotation: α D =−72.8°+/−1.2 (c=2.338 mg in 0.5 ml of methanol). 
     EXAMPLE 119 
     Synthesis of 3-methyl-2-[2-(3-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 68, using 275 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 254 mg of 3-methylindoline hydrochloride and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 161 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 96 mg of 3-methyl-2-[2-(3-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a pink powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.30 (d, J=6.8 Hz, 3 H); 3.32 (s, 3 H); 3.39 (m, 4 H); 3.49 (m, 1 H); 3.57 (m, 4 H); 3.71 (dd, J=6.8 and 10.1 Hz, 1 H); 4.10 (s, 2 H); 4.36 (t, J=10.1 Hz, 1 H); 5.36 (s, 1 H); 7.05 (t, J=8.0 Hz, 1 H); 7.17 (t, J=8.0 Hz, 1 H); 7.28 (d, J=8.0 Hz, 1 H); 8.01 (d, J=8.0 Hz, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.77; 
     [M+H] + : mz 369; [M−H] − : mz 367 
     Melting point (Kofler bench): 225° C. 
     EXAMPLE 120 
     Synthesis of 2-{2-[2-(methoxymethyl)-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 326 mg of 2-(methoxymethyl)indoline and 249 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 162 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 143 mg of 2-{2-[2-(methoxymethyl)-2,3-dihydro-1 H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a beige powder, the characteristics of which are the following: 
       1  H NMR spectrum (400 MHz): 2.84 (d, J=16.4 Hz, 1 H); 3.26 (s, 3 H); 3.34 to 3.46 (m, 7H); 3.60 (m, 4 H); 3.79 (d, J=15.6 Hz, 1 H); 4.00 (d, J=15.6 Hz, 1 H); 4.80 (m, 1 H); 5.20 (s, 1 H); 7.03 (t, J=7.8 Hz, 1 H); 7.17 (t, J=7.8 Hz, 1 H); 7.27 (d, J=7.8 Hz, 1 H); 7.93 (d, J=7.8 Hz, 1 H); 11.66 (broad s, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.26; 
     [M+H] + : mz 385; [M−H] − : mz 383 
     Melting point (Kofler bench): 112-115° C. 
     EXAMPLE 121 
     Synthesis of 2-[2-(4-ethoxy-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 163 mg of 4-(ethoxy)indoline and 249 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 162 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 260 mg of 2-[2-(4-ethoxy-2,3-dihydro-1 H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.33 (t, J=6.8 Hz, 3 H); 3.03 (t, J=8.6 Hz, 2 H); 3.42 (m, 4 H); 3.61 (m, 4 H); 3.73 (s, 2 H); 4.06 (q, J=6.8 Hz, 2 H); 4.14 (t, J=8.6 Hz, 2 H); 5.20 (s, 1 H); 6.68 (d, J=8.1 Hz, 1 H); 7.12 (t, J=8.1 Hz, 1 H); 7.63 (d, J=8.1 Hz, 1 H); 11.61 (broad s, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.48; 
     [M+H] + : mz 385; [M−H] − : mz 383 
     Melting point (Kofler bench): 257° C. 
     EXAMPLE 122 
     Synthesis of 1-{[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}-2,3-dihydro-1H-indole-2-carboxamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 324 mg of 2-carboxamidoindoline and 249 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 162 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 93 mg of 1-{[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}-2,3-dihydro-1 H-indole-2-carboxamide are obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.11 (d, J=16.9 Hz, 1 H); 3.36 to 3.47 (m, 5H); 3.54 to 3.63 (m, 5H); 3.77 (d, J=15.7 Hz, 1 H); 5.07 (dd, J=3.8 and 9.1 Hz, 1 H); 5.20 (s, 1 H); 7.02 (t, J=7.8 Hz, 1 H); 7.18 (t, J=7.8 Hz, 1 H); 7.23 (d, J=7.8 Hz, 1 H); 7.36 (broad s, 1 H); 7.76 (broad s, 1 H); 8.01 (d, J=7.8 Hz, 1 H); 11.59 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.50; 
     [M+H] + : mz 384; [M−H] − : mz 382 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 123 
     Synthesis of 3-methyl-2-[2-(2-methyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 68, using 550 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 400 mg of 2-methylindoline and 500 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 320 μl of pyridine and 8.0 ml of N,N-dimethylformamide. 37 mg of 3-methyl-2-[2-(2-methyl-2,3-di hydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a pink powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.28 (d, J=6.8 Hz, 3 H); 2.70 (d, J=15.9 Hz, 1 H); 3.23 to 3.30 (s masked, 3 H); 3.40 (m, 5H); 3.60 (m, 4 H); 4.02 (d, J=16.9 Hz, 1 H); 4.29 (d, J=16.9 Hz, 1 H); 4.70 (m, 1 H); 5.36 (s, 1 H); 7.05 (t, J=7.8 Hz, 1 H); 7.18 (t, J=7.8 Hz, 1 H); 7.29 (d, J=7.8 Hz, 1 H); 7.95 (d, J=7.8 Hz, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.75; 
     [M+H] + : mz 369; [M−H] − : mz 367 
     Melting point (Kofler bench): 148° C. 
     EXAMPLE 124 
     Synthesis of 2-[2-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 68, using 275 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 205 mg of 6-fluoroindoline and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 161 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 140 mg of 2-[2-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a very pale pink powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.14 (t, J=8.2 Hz, 2 H); 3.25 to 3.45 (m partially masked, 7H); 3.58 (m, 4 H); 4.11 (s, 2 H); 4.22 (t, J=8.2 Hz, 2 H); 5.36 (s, 1 H); 6.84 (t, J=8.7 Hz, 1 H); 7.26 (m, 1 H); 7.77 (broad d, J=10.3 Hz, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.73; 
     [M+H] + : mz 373; mz 371 
     Melting point (Kofler bench): 223° C. 
     EXAMPLE 125 AND EXAMPLE 126 
     Separation of 2-{2-[(3S)-3-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3 H)-one and 2-{2-[(3R)-3-methyl-2,3-di hydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The products were obtained by chiral chromatographic separation of 369 mg of 2-{2-[3-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one (example 101) on a Chiralpak T304 20 μm chiral column (1100 g, 20 μm, 835 cm), eluent: heptane/ethanol/methanol: 254035; flow rate: 200 ml/min. After purification, 168 mg of (+)-2-{2-[3-methyl-2,3-di hydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3 H)-one are obtained, as first enantiomer, in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.29 (d, J=6.8 Hz, 3 H); 3.42 (m, 4 H); 3.49 (m, 1H); 3.60 (m, 4 H); 3.68 (dd, J=6.6 and 10.1 Hz, 1 H); 3.75 (s, 2 H); 4.33 (t, J=10.1 Hz, 1 H); 5.21 (s, 1 H); 7.04 (t, J=8.0 Hz, 1 H); 7.18 (t, J=8.0 Hz, 1 H); 7.27 (d, J=8.0 Hz, 1 H); 8.01 (d, J=8.0 Hz, 1 H); 11.61 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.72; 
     [M+H] + : mz 355; [M−H] − : mz 353; 
     Optical rotation: α D =+17.1°+/−0.8 (c=1.656 mg in 0.5 ml of DMSO); 
     Then the second enantiomer, i.e.: 164 mg of (−)-2-{2-[3-methyl-2,3-dihydro-1 H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one, is obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.29 (d, J=6.8 Hz, 3 H); 3.41 (m, 4 H); 3.49 (m, 1 H); 3.60 (m, 4 H); 3.68 (dd, J=6.6 and 10.3 Hz, 1 H); 3.75 (s, 2 H); 4.33 (t, J=10.3 Hz, 1 H); 5.21 (s, 1 H); 7.05 (t, J=8.0 Hz, 1 H); 7.18 (t, J=8.0 Hz, 1 H); 7.27 (d, J=8.0 Hz, 1 H); 8.01 (d, J=8.0 Hz, 1 H); 11.60 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.72; 
     [M+H] + : mz 355; [M−H] − : mz 353; 
     Optical rotation: α D =−13.0° (c=1.386 mg in 0.5 ml of DMSO). 
     EXAMPLE 127 
     Synthesis of 2-[2-(5,6-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 68, using 275 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 232 mg of 5,6-difluoroindoline and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 161 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 167 mg of 2-[2-(5,6-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of an off-white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.16 (t, J=8.6 Hz, 2 H); 3.31 (s, 3 H); 3.39 (m, 4 H); 3.58 (m, 4 H); 4.11 (s, 2 H); 4.22 (t, J=8.6 Hz, 2 H); 5.36 (s, 1 H); 7.37 (dd, J=8.9 and 10.3 Hz, 1 H); 7.95 (dd, J=7.5 and 12.1 Hz, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.76; 
     [M+H] + : mz 391; [M−H] − : mz 389 
     Melting point (Kofler bench): 250° C. 
     EXAMPLE 128 
     Synthesis of 2-[2-(4,5-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 68, using 275 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 287 mg of 4,5-difluoroindoline hydrochloride and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 241 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 155 mg of 2-[2-(4,5-difluoro-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-3-methyl-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a brick-red coloured powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.25 (t, J=8.4 Hz, 2 H); 3.31 (s, 3 H); 3.39 (m, 4 H); 3.58 (m, 4 H); 4.11 (s, 2 H); 4.27 (t, J=8.4 Hz, 2 H); 5.36 (s, 1 H); 7.23 (m, 1 H); 7.79 (dd, J=4.3 and 8.9 Hz, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.77; 
     [M+H] + : mz 391; [M−H] − : mz 389 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 129 
     Synthesis of 2-[2-(1,3-dihydro-2H-isoindol-2-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 70, using 250 mg of isoindoline, 267 mg of ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 1 of example 1 and 1.15 ml of a 2M solution of trimethylaluminium, in a mixture of 20 ml of toluene and 10 ml of tetrahydrofuran. 80 mg of 2-[2-(1,3-dihydro-2H-isoindol-2-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are thus obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.39 (m, 4 H); 3.59 (m, 4 H); 3.67 (s, 2H); 4.67 (s, 2 H); 4.90 (s, 2 H); 5.19 (s, 1 H); 7.26 to 7.42 (m, 4 H); 11.60 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.60; 
     [M+H] + : m/z 341; [M−H] − : mz 339 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 130 
     Synthesis of N-(1-benzothiophen-4-yl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 86, using 551 mg of sodium [1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 328 mg of benzo[b]thiophen-4-ylamine and 498 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 324 μl of pyridine and 8.0 ml of N,N-dimethylformamide. 110 mg of N-(1-benzothiophen-4-yl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.38 (s, 3 H); 3.41 (m, 4 H); 3.57 (m, 4H); 4.05 (s, 2 H); 5.36 (s, 1 H); 7.34 (t, J=7.9 Hz, 1 H); 7.63 (d, J=5.6 Hz, 1 H); 7.72 to 7.81 (m, 3 H); 10.14 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.71; 
     [M+H] + : mz 385; [M−H] − : mz 383 
     Melting point (Kofler bench): 254° C. 
     EXAMPLE 131 
     Synthesis of 2-[2-(5-chloro-3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 184 mg of 5-chloro-1,2,3,4-tetrahydroquinoline (can be prepared according to WO 20040116388), and 249 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 162 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 141 mg of 2-[2-(5-chloro-3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.96 (m, 2 H); 2.77 (t, J=6.8 Hz, 2 H); 3.41 (m, 4H); 3.61 (m, 4 H); 3.70 (t, J=6.8 Hz, 2 H); 3.79 (s, 2 H); 5.16 (s, 1 H); 7.21 (t, J=8.0 Hz, 1 H); 7.27 (d, J=8.0 Hz, 1 H); 7.55 (broad d, J=8.0 Hz, 1 H); 11.57 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.78; 
     [M+H] + : mz 389; [M−H] − : mz 387 
     Melting point (Kofler bench): 238° C. 
     EXAMPLE 132 
     Synthesis of 2-{2-[4-(hydroxymethyl)-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 173 mg of 4-(hydroxymethyl)indoline and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 161 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 288 mg of 2-{2-[4-(hydroxymethyl)-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a pink powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.12 (t, J=8.3 Hz, 2 H); 3.42 (m, 4 H); 3.59 (m, 4 H); 3.75 (s, 2 H); 4.15 (t, J=8.3 Hz, 2 H); 4.46 (d, J=5.4 Hz, 2 H); 5.10 (t, J=5.4 Hz, 1 H); 5.21 (s, 1 H); 7.04 (d, J=7.8 Hz, 1 H); 7.15 (t, J=7.8 Hz, 1 H); 7.92 (d, J=7.8 Hz, 1 H); 11.62 (broad s, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=2.48; 
     [M+H] + : mz 371; [M−H] − : mz 369 
     Melting point (Kofler bench): 234° C. 
     EXAMPLE 133 
     Synthesis of N-[4-fluoro-2-(piperidin-4-ylmethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
                         
Stage 1
 
     
       
         
         
             
             
         
       
     
     3 ml of pyridine, 500 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 930 mg of 4-(2-amino-5-fluorophenoxymethyl)piperidine-1-carboxylic acid tert-butyl ester are added to a solution of 500 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, in 3 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 2 days, and then concentrated under reduced pressure. After silica column purification, elution being carried out with a mixture of dichloromethane and methanol (95/05 by volume), 225 mg of 4-{5-fluoro-2-[2-(4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetylamino]phenoxymethyl}piperidine-1-carboxylic acid tert-butyl ester are obtained in the form of a purplish solid, the characteristics of which are the following: 
     Mass spectrometry: method B 
     Retention time Tr (min)=4.02; 
     [M+H] + : mz 544; [M−H] − : mz 546. 
     Stage 2 
     1.5 ml of 4M hydrochloric acid in dioxane are added to a solution of 223 mg of 4-{5-fluoro-2-[2-(4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetylamino]phenoxymethyl}piperidine-1-carboxylic acid tert-butyl ester in 6 ml of ethanol. After stirring at ambient temperature for 20 h, the reaction medium is concentrated under reduced pressure, taken up with a solution of aqueous ammonia in methanol, and then again concentrated to dryness. After purification by silica column chromatography, eluent: 90/10 CH 2 Cl 2 /MeOH, 65 mg of N-[4-fluoro-2-(piperidin-4-ylmethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.52 (m, 2 H); 1.89 (m, 2 H); 2.06 (m, 1 H); 2.86 (m, 2 H); 3.25 (m partially masked, 2 H); 3.43 (m, 4 H); 3.62 (m, 4 H); 3.71 (s, 2 H); 3.92 (d, J=6.4 Hz, 2 H); 5.22 (s, 1 H); 6.74 (dt, J=2.7 and 8.8 Hz, 1 H); 7.00 (dd, J=2.7 and 11.0 Hz, 1 H); 7.75 (dd, J=6.6 and 8.8 Hz, 1 H); 7.87 (very broad m, 2 H); 9.22 (broad s, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.48; 
     [M+H] + : mz 444; [M−H] − : mz 446. 
     EXAMPLE 134 
     2-[2-(5-Chloro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 307 mg of 5-chloroindoline and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.16 ml of pyridine and 4 ml of dimethylformamide. 255 mg of 2-[2-(5-chloro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one are obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz, δ in ppm, DMSO-d 6 ): 3.18 (t, J=8.3 Hz, 2H); 3.41 (m, 4 H); 3.60 (m, 4 H); 3.75 (s, 2 H); 4.16 (t, J=8.3 Hz, 2 H); 5.20 (s, 1 H); 7.21 (broad d, J=8.6 Hz, 1 H); 7.32 (broad s, 1 H); 7.99 (d, J=8.6 Hz, 1 H); 11.61 (broad m, 1 H). 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.42; 
     [M−H] − : mz 373 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 135 
     2-[2-(4-Bromo-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 402 mg of 4-bromoindoline and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.16 ml of pyridine and 4 ml of dimethylformamide. 303 mg of 2-[2-(4-bromo-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one are obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz, δ in ppm, DMSO-d 6 ): 3.14 (t, J=8.4 Hz, 2H); 3.41 (m, 4 H); 3.61 (m, 4 H); 3.76 (s, 2 H); 4.19 (t, J=8.4 Hz, 2 H); 5.21 (s, 1 H); 7.14 (t, J=8.1 Hz, 1 H); 7.23 (broad d, J=8.1 Hz, 1 H); 8.01 (broad d, J=8.1 Hz, 1 H); 11.62 (broad m, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.88; 
     [M+H] + : mz 419; [M−H] − : m/z 417 
     Melting point (Kofler bench): 219° C. 
     EXAMPLE 136 AND EXAMPLE 137 
     Separation of 2-(2-{(3S)-3-[(dimethylamino)methyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-6-(morpholin-4-yl)pyrimidin-4(3H)-one and 2-(2-{(3R)-3-[(dimethylamino)methyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The products were obtained by chiral chromatographic separation of 500 mg of 2-[2-(3-dimethylaminomethyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one (example 115) on a Chiralpak AD 20 μm chiral column (batch CFB003) (1200 g, 20 μm, 8035 mm), eluent: heptane/methanol/ethanol: 502030; flow rate: 160 ml/min. After purification, 226 mg of (+)-2-[2-(3-dimethylaminomethyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one are obtained, as first enantiomer, in the form of a yellow solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 2.22 (s, 6 H); 2.36 (dd, J=10.0 and 11.7 Hz, 1 H); 2.46 (dd, J=5.4 and 11.7 Hz, 1 H); 3.41 (m, 4 H); 3.60 (m, 5H); 3.76 (m, 2 H); 3.91 (dd, J=5.7 and 10.0 Hz, 1 H); 4.23 (t, J=10.0 Hz, 1 H); 5.21 (s, 1 H); 7.02 (t, J=7.8 Hz, 1 H); 7.19 (t, J=7.8 Hz, 1 H); 7.29 (d, J=7.8 Hz, 1 H); 8.03 (d, J=7.8 Hz, 1 H); 11.61 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.40; 
     [M+H] + : mz 398; [M−H] − : mz 396 
     Melting point (Kofler bench): 246° C. 
     Optical rotation: 1.830 mg in 1 ml of DMSO positive sign. 
     Then the second enantiomer, i.e.: 239 mg of (−)-2-[2-(3-dimethylaminomethyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one, is obtained in the form of a yellow solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 2.22 (s, 6 H); 2.36 (dd, J=10.0 and 11.7 Hz, 1 H); 2.46 (dd, J=5.4 and 11.7 Hz, 1 H); 3.41 (m, 4 H); 3.60 (m, 5H); 3.76 (m, 2 H); 3.91 (dd, J=5.7 and 10.0 Hz, 1 H); 4.23 (t, J=10.0 Hz, 1 H); 5.21 (s, 1 H); 7.02 (t, J=7.8 Hz, 1 H); 7.19 (t, J=7.8 Hz, 1 H); 7.29 (d, J=7.8 Hz, 1 H); 8.03 (d, J=7.8 Hz, 1 H); 11.62 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.40; 
     [M+H] + : mz 398; [M−H] − : mz 396 
     Melting point (Kofler bench): 256° C. 
     Optical rotation: 1.721 mg in 1 ml of DMSO negative sign. 
     EXAMPLE 138 
     Synthesis of N-[4-fluoro-2-(2-methoxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     3 ml of pyridine, 500 mg of N-[3-(dimethylamino)propyl]-N-ethylcarbodiimide hydrochloride and 590 mg of 4-fluoro-2-(2-methoxyethoxy)phenylamine are added to a solution of 500 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, in 3 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 15 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 155 mg of N-[4-fluoro-2-(2-methoxyethoxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a pinkish solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.17 to 3.33 (m partially masked, 3 H); 3.43 (m, 4 H); 3.62 (m, 4 H); 3.68 (m, 4 H); 4.21 (m, 2 H); 5.21 (s, 1 H); 6.75 (dt, J=2.7 and 8.8 Hz, 1 H); 7.02 (dd, J=2.7 and 10.8 Hz, 1 H); 7.85 (dd, J=6.8 and 8.8 Hz, 1 H); 9.28 (broad s, 1 H); 11.65 (broad m, 1 H) 
     Mass spectrometry: method B 
     Retention time Tr (min)=3.60; 
     [M+H] + : mz 405; [M−H] − : mz 407. 
     EXAMPLE 139 
     Synthesis of N-(1H-benzimidazol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 130 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 113 mg of 4-aminobenzimidazole hydrochloride and 127 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 80 μl of pyridine and 2.0 ml of N,N-dimethylformamide. 112 mg of N-(1H-benzimidazol-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of an off-white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.48 (m, 4 H); 3.60 (m, 4 H); 3.79 (broad s, 2 H); 5.21 (s, 1 H); 7.14 (t, J=8.1 Hz, 1 H); 7.26 (broad s, 1 H); 7.94 (broad s, 1 H); 8.21 (s, 1 H); 10.20 (broad s, 1 H); 11.70 (broad m, 1 H); 12.54 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.32; 
     [M+H] + : mz 355; [M−H] − : mz 353 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 140 
     Synthesis of methyl 2-hydroxy-3-(([4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl)amino)benzoate 
     
       
         
         
             
             
         
       
     
     6 ml of pyridine, 1g of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 1 g of methyl 3-amino-2-hydroxybenzoate are added to a solution of 1 g of [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, in 6 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 15 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 1.27 g of methyl 2-hydroxy-3-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate are obtained in the form of a grey solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.45 (m, 4 H); 3.58 (m, 4 H); 3.73 (s, 2H); 3.94 (s, 3 H); 5.21 (s, 1 H); 6.95 (t, J=7.9 Hz, 1 H); 7.56 (dd, J=1.3 and 7.9 Hz, 1 H); 8.21 (broad d, J=7.9 Hz, 1 H); 9.71 (broad s, 1 H); 11.03 (broad s, 1H); 11.70 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.66; 
     [M+H] + : mz 387; [M−H] − : mz 389. 
     EXAMPLE 141 
     2-[2-(4-Methoxy-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 308 mg of 4-methoxyindoline and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.16 ml of pyridine and 4 ml of dimethylformamide. 269 mg of 2-[2-(4-methoxy-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one are obtained in the form of a pinkish powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz, δ in ppm, DMSO-d 6 ): 3.04 (t, J=8.2 Hz, 2H); 3.41 (m, 4 H); 3.61 (m, 4 H); 3.74 (s, 2 H); 3.79 (s, 3 H); 4.14 (t, J=8.2 Hz, 2 H); 5.20 (s, 1 H); 6.70 (broad d, J=7.9 Hz, 1 H); 7.15 (t, J=7.9 Hz, 1 H); 7.64 (broad d, J=7.9 Hz, 1 H); 11.61 (broad m, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.75; 
     [M+H] + : mz 371; [M−H] − : mz 369 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 142 
     N-(3-bromo-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     600 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 550 mg of 2-amino-6-bromophenol are added to a solution of 500 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, in 4 ml of pyridine. The reaction mixture is stirred at ambient temperature for 20 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 543 mg of N-(3-bromo-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a beige solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.44 (m, 4 H); 3.62 (m, 4 H); 3.70 (s, 2H); 5.21 (s, 1 H); 6.78 (t, J=8.1 Hz, 1 H); 7.32 (d, J=8.1 Hz, 1 H); 7.56 (d, J=8.1 Hz, 1 H); 9.82 (broad m, 2 H); 11.62 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.64; 
     [M+H] + : mz 408; [M−H] − : mz 410. 
     EXAMPLE 143 
     Synthesis of N-(3,4-dihydro-2H-1,4-benzoxazin-8-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 166 mg of 3,4-dihydro-2H-1,4-benzoxazin-8-ylamine and 249 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 162 μl of pyridine and 4.0 ml of N,N-dimethylformamide. 100 mg of N-(3,4-dihydro-2H-1,4-benzoxazin-8-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.32 (m partially masked, 2 H); 3.44 (m, 4 H); 3.62 (m, 6 H); 4.08 (m, 2 H); 5.08 (m, 1 H); 5.19 (s, 1 H); 6.49 (t, J=7.8 Hz, 1 H); 6.56 (dd, J=1.5 and 7.8 Hz, 1 H); 6.80 (dd, J=1.5 and 7.8 Hz, 1 H); 9.43 (broad m, 1 H); 11.63 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=2.64; 
     [M+H] + : mz 372; [M−H] − : mz 370 
     Melting point (Kofler bench): 243° C. 
     EXAMPLE 144 
     Methyl 5-fluoro-2-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 300 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 303 mg of methyl 2-amino-5-fluorobenzoate and 308 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 2 ml of pyridine and 2 ml of dimethylformamide. 310 mg of methyl 5-fluoro-2-({[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetyl}amino)benzoate are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.44 (m, 4 H); 3.61 (m, 4 H); 3.67 (s, 2H); 3.84 (s, 3 H); 5.21 (s, 1 H); 7.50 (m, 1 H); 7.64 (dd, J=3.0 and 9.2 Hz, 1 H); 8.13 (dd, J=5.3 and 8.9 Hz, 1 H); 10.57 (broad s, 1 H); 11.70 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.71; 
     [M+H] + : mz 391; [M−H] − : mz 389. 
     EXAMPLE 145 
     Synthesis of 2-(2-{3-[(diethylamino)methyl]-2,3-dihydro-1 H-indol-1-yl}-2-oxoethyl)-6-(morpholin-4-yl)pyrimidin-4(3 H)-one 
                         
Stage 1
 
     
       
         
         
             
             
         
       
     
     0.48 g of sodium cyanoborohydride is gradually added to a solution of 0.5 g of diethyl(1H-indol-3-ylmethyl)amine (prepared according to Synth. Commun. 2006, 1829) in 10 ml of trifluoroacetic acid, under argon, cooled in an ice bath, and then the resulting mixture is stirred for half an hour at 0° C. and 3 h at ambient temperature. The reaction medium is then plunged into 100 ml of water and alkalinized using 30% sodium hydroxide. After the addition of 100 ml of ethyl acetate, the resulting mixture is stirred for 10 min at ambient temperature and then the mixture is separated by settling out and the aqueous phase is extracted with three times 50 ml of ethyl acetate. The organic phases are combined, and then washed with 40 ml of water. The organic phase is dried over anhydrous magnesium sulphate, filtered and concentrated to dryness under reduced pressure. The residue is taken up with 20 ml of 2N sodium hydroxide plus 40 ml of water and 60 ml of ethyl acetate, stirred for 5 min, and then separated by settling out. The aqueous phase is extracted with twice 40 ml of ethyl acetate and the organic phases are combined, dried over anhydrous magnesium sulphate, filtered and concentrated to dryness under reduced pressure. After a silica column purification, eluent: 89101 CH 2 Cl 2 /MeOH/NH 4 OH, 246 mg of (2,3-dihydro-1H-indol-3-ylmethyl)diethylamine are obtained in the form of a yellow oil, the characteristics of which are the following: 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.20; 
     [M+H] + : mz 205; 
     Stage 2 
     The product is prepared according to the procedure described in example 5, using 150 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 238 mg of (2,3-dihydro-1H-indol-3-ylmethyl)diethylamine and 140 mg of N-[3-(dimethylamino)propyl]-N-ethylcarbodiimide hydrochloride in a mixture of 0.1 ml of pyridine and 3 ml of N,N-dimethylformamide. 108 mg of 2-(2-{3-[(diethylamino)methyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a cream solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 0.96 (t, J=7.0 Hz, 6 H); 2.36 to 2.71 (m partially masked, 6 H); 3.41 (m, 4 H); 3.56 (m, 1 H); 3.61 (m, 4 H); 3.75 (s, 2H); 3.88 (dd, J=5.4 and 10.8 Hz, 1 H); 4.21 (t, J=10.8 Hz, 1 H); 5.21 (s, 1 H); 7.02 (t, J=7.7 Hz, 1 H); 7.18 (t, J=7.7 Hz, 1 H); 7.32 (d, J=7.7 Hz, 1 H); 8.03 (d, J=7.7 Hz, 1 H); 11.62 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.43; 
     [M+H] + : mz 426; [M−H] − : mz 424 
     Melting point (Kofler bench): 202° C. 
     EXAMPLE 146 
     Synthesis of 2-[2-(2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
                         
Stage 1
 
     
       
         
         
             
             
         
       
     
     1.49 g of Raney nickel at 50% in water are added to a solution of 1.5 g of 4-azaindole in 45 ml of absolute ethanol, in an autoclave under argon. The mixture is hydrogenated under 100 bar of hydrogen at a temperature of 95° C. for 41 h. After a return to ambient temperature, the catalyst is filtered off through Clarcel and the filtrate is concentrated to dryness under reduced pressure. The residue is purified by chromatography on a 70 g 15-40 μm silica cartridge, elution being carried out with pure dichloromethane and then with a 99/1 v/v mixture of dichloromethanemethanol with a flow rate of 80 ml/min, and then on a 30 g 15-40 μm silica cartridge, elution being carried out with pure dichloromethane with a flow rate of 30 ml/min. 0.18 g of 4-azaindoline is thus obtained in the form of a pale yellow solid which melts at 63° C. (Kofler bench). 
     Stage 2 
     The product is prepared according to the procedure described in example 5, using 350 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 177 mg of 4-azaindoline and 340 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 216 μl of pyridine and 6.5 ml of N,N-dimethylformamide. 252 mg of 2-[2-(2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.24 to 3.37 (m partially masked, 2H); 3.41 (m, 4 H); 3.60 (m, 4 H); 3.79 (s, 2 H); 4.19 (t, J=8.3 Hz, 2 H); 5.21 (s, 1 H); 7.17 (dd, J=4.4 and 8.3 Hz, 1 H); 8.13 (d, J=4.4 Hz, 1 H); 8.19 (d, J=8.3 Hz, 1 H); 11.63 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.37; 
     [M+H] + : mz 342; [M−H] − : mz 340 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 147 
     2-[2-(5,6-Difluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 310 mg of 4-methoxyindoline and 254 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.16 ml of pyridine and 4 ml of dimethylformamide. 245 mg of 2-[2-(5,6-difluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one are obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz, 6 in ppm, DMSO-d 6 ): 3.16 (t, J=8.4 Hz, 2H); 3.41 (m, 4 H); 3.60 (m, 4 H); 3.76 (s, 2 H); 4.19 (t, J=8.4 Hz, 2 H); 5.21 (s, 1 H); 7.37 (t, J=9.2 Hz, 1 H); 7.95 (dd, J=7.6 and 12.0 Hz, 1 H); 11.61 (broad m, 1 H). 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.70; 
     [M+H] + : mz 377; [M−H] − : mz 375 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 148 
     Synthesis of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(1,2,3,4-tetrahydroquinolin-8-yl)acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 340 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 212 mg of 8-amino-1,2,3,4-tetrahydroquinoline and 330 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 210 μl of pyridine and 5.0 ml of N,N-dimethylformamide. 243 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(1,2,3,4-tetrahydroquinolin-8-yl)acetamide are obtained in the form of a beige powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.79 (m, 2 H); 2.70 (t, J=6.5 Hz, 2 H); 3.23 (broad t, J=6.5 Hz, 2 H); 3.44 (m, 4 H); 3.59 (s, 2 H); 3.63 (m, 4 H); 5.03 (broad s, 1 H); 5.20 (s, 1 H); 6.43 (t, J=7.7 Hz, 1 H); 6.75 (d, J=7.7 Hz, 1 H); 6.93 (d, J=7.7 Hz, 1 H); 9.22 (broad s, 1 H); 11.62 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.57; 
     [M+H] + : mz 370; [M−H] − : mz 368 
     Melting point (Kofler bench): 232° C. 
     EXAMPLE 149 
     Synthesis of 2-[2-(8-chloro-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 220 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 157 mg of 8-chloro-2H-benzo[b][1,4]oxazine (which can be prepared according to WO 2008100463) and 214 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 135 μl of pyridine and 3.5 ml of N,N-dimethylformamide. 140 mg of 2-[2-(8-chloro-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a white powder, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): for this batch, all the signals are broad, with: 3.41 (m, 4 H); 3.57 (m, 4H); 3.88 (m, 4 H); 4.42 (m, 2 H); 5.17 (s, 1 H); 6.88 (m, 1 H); 7.24 (m, 1 H); 7.71 (very broad m, 1 H); 11.57 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.71; 
     [M+H] + : mz 391; [M−H] − : mz 389 
     Melting point (Kofler bench): above 260° C. 
     EXAMPLE 150 
     Synthesis of N-(2-hydroxy-3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 1 g of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 680 mg of 6-amino-2-methylphenol and 1.2 g of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 6 ml of pyridine and 8 ml of N,N-dimethylformamide. 1.1 g of N-(2-hydroxy-3-methyl phenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a beige solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 2.18 (s, 3 H); 3.45 (m, 4 H); 3.62 (m, 4 H); 3.70 (s, 2 H); 5.21 (s, 1 H); 6.73 (t, J=7.8 Hz, 1 H); 6.91 (d, J=7.8 Hz, 1 H); 7.37 (d, J=7.8 Hz, 1 H); 8.80 (broad s, 1 H); 9.77 (s, 1 H); 11.68 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.61; 
     [M+H] + : mz 345; [M−H] − : mz 343. 
     EXAMPLE 151 
     N-(2-hydroxy-3-nitrophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 1 g of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 590 mg of 2-amino-6-nitrophenol, and 734 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 5 ml of pyridine and 6 ml of N,N-dimethylformamide. 976 mg of N-(2-hydroxy-3-nitrophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a yellow solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.48 (m, 4 H); 3.63 (m, 4 H); 3.65 (s, 2 H); 5.19 (s, 1 H); 5.85 (dd, J=7.2 and 8.7 Hz, 1 H); 7.37 (dd, J=1.7 and 8.7 Hz, 1 H); 7.91 (dd, J=1.7 and 7.2 Hz, 1 H); 9.74 (broad m, 1 H); 11.75 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.61; 
     [M+H] + : mz 376; [M−H] − : mz 374. 
     EXAMPLE 152 
     N-(3-cyano-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 1 g of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 513 mg of 3-amino-2-hydroxybenzonitrile and 734 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 5 ml of pyridine and 5 ml of N,N-dimethylformamide. 257 mg of N-(3-cyano-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.44 (m, 4 H); 3.62 (m, 4 H); 3.70 (s, 2 H); 5.21 (s, 1 H); 6.91 (t, J=7.8 Hz, 1 H); 7.40 (d, J=7.8 Hz, 1 H); 7.78 (d, J=7.8 Hz, 1 H); 9.95 (broad m, 1 H); 10.71 (very broad m, 1 H); 11.64 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.57; 
     [M+H] + : mz 356; [2M+H] + : mz 711 (base peak) 
     [M−H] − : mz 354 (base peak); [2M−H]: mz 709. 
     EXAMPLE 153 
     N-[2-hydroxy-3-(trifluoromethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 1 g of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 978 mg of 2-hydroxy-3-(trifluoromethyl)aniline and 1.2 g of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 6 ml of pyridine and 8 ml of N,N-dimethylformamide. 600 mg of N-[2-hydroxy-3-(trifluoromethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a beige solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 3.44 (m, 4 H); 3.61 (m, 4 H); 3.69 (s, 2 H); 5.21 (s, 1 H); 6.95 (t, J=7.8 Hz, 1 H); 7.38 (d, J=7.8 Hz, 1 H); 7.57 (d, J=7.8 Hz, 1 H); 10.44 (very broad m, 3 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.71; 
     [M+H] + : mz 399; [M−H]: mz 397. 
     EXAMPLE 154 
     Synthesis of 2-[2-(3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
     
       
         
         
             
             
         
       
     
     The product is prepared according to the procedure described in example 5, using 177 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 236 mg of 3,3-dimethylindoline (which can be prepared according to T. W. Ramsay et al., Synth. Commun. 1995, 25, 4029) and 169 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.11 ml of pyridine and 5 ml of N,N-dimethylformamide. The reaction mixture is stirred for 15 h at ambient temperature and then concentrated to dryness under reduced pressure. 40 ml of water are added to the residue and triturated with a spatula at ambient temperature. The precipitate formed is filtered off, and then solubilized with a dichloromethanemethanol mixture and dried. After concentration to dryness under reduced pressure, the crude product is purified by chromatography on a 30 g silica (0.02-0.045 mm) column, eluent: 90/10 v/v dichloromethanemethanol. After the various fractions have been evaporated, the pink solid residue is triturated from 10 ml of diisopropyl ether, filtered off, and then dried under a bell jar (1h40° C./20 mbar). 134 mg of 2-[2-(3,3-dimethyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one are thus obtained in the form of a pink solid, the characteristics of which are the following: 
       1 H NMR spectrum (400 MHz): 1.31 (s, 6H); 3.42 (m, 4 H); 3.59 (m, 4H); 3.75 (s, 2 H); 3.91 (s, 2 H); 5.20 (s, 1 H); 7.05 (t, J=7.6 Hz, 1 H); 7.18 (t, J=7.6 Hz, 1 H); 7.27 (d, J=7.6 Hz, 1 H); 8.00 (d, J=7.6 Hz, 1 H); 11.61 (broad m, 1 H) 
     Mass spectrometry: method A 
     Retention time Tr (min)=0.77; 
     [M+H] + : mz 369; [M−H] − : mz 367 
     Melting point (Kofler bench): 248° C. 
     EXAMPLE 155 
     Pharmaceutical Composition 
     Tablets corresponding to the following formulation were prepared: 
     
       
         
           
               
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Product of Example 1 
                 0.2  
                 g 
               
               
                   
                 Excipient for a tablet with a  
                 1  
                 g 
               
            
           
           
               
               
               
            
               
                   
                 final weight of 
                   
               
            
           
           
               
               
            
               
                   
                 (details of the excipient: lactose, talc, starch,  
               
               
                   
                 magnesium stearate). 
               
               
                   
                   
               
            
           
         
       
     
     Example 1 is taken by way of example of a pharmaceutical preparation, it being possible for this preparation to be carried out, if desired, with other products as examples in the present application. 
     Pharmacological Section: 
     Experimental Protocols 
     In Vitro Experimental Procedures 
     The inhibitory activity of the molecules on AKT phosphorylation is measured either by western blotting using the technique described below, or by the MSD Multi-spot Biomarker detection technique from Meso Scale Discovery also described below. It was demonstrated, on one set of molecules, that both techniques give compatible results. 
     Study of pAKT Expression in PC3 Human Prostate Carcinoma Cells Measured by Western Blotting (Test A): 
     This test is based on measuring the expression of the AKT protein phosphorylated on serine 473. The phosphorylation of AKT (pAKT) is measured by western blotting in the PC3 human prostate carcinoma line (ATCC CRL-1435), using an antibody that specifically recognises pAKT-S473. 
     On day 1, the PC3 cells are seeded into 6-well plates (TPP, #92006) at the concentration of 0.8×10 6  cells/well in 1800 μl of DMEM medium (DMEM Gibco #11960-044) containing 10% of foetal calf serum (SVF Gibco, #10500-056) and 1% glutamine (L-Glu Gibco #25030-024), and incubated at 37° C., 5% CO 2 , overnight. 
     On day 2, the cells are incubated in the presence or absence of the test products for 1 to 2 hours at 37° C. in the presence of 5% CO 2 . The molecules, diluted in dimethyl sulphoxide (DMSO Sigma #D2650), are added from a 10-times concentrated stock solution, the final percentage of DMSO being 0.1%. The molecules are tested either at a single concentration of less than or equal to 10 μM, or at increasing concentrations in a range that can extend from less than 1 nM to 10 μM. 
     After this incubation, the cells are lysed for the preparation of the proteins. After the culture medium has been drawn off, the cells are rinsed with 1 ml of PBS (DPBS Gibco, #14190-094), recovered by scraping in 200 μl of complete HNTG buffer and transferred into a 96-well plate (Greiner #651201), and lysed for 1 h on ice. The HNTG buffer is composed of the following mixture: 50 mM hepes, 150 mM Nacl, 1% triton, 10% glycerol, with extemporaneous addition of one Mini Protease Inhibitor Cocktail tablet (Roche 1836153) and of one Phosphatase Inhibitor Cocktail tablet (Roche104906837001) per 10 ml of buffer. 
     The lysate is centrifuged for 10 min at 6000 rpm. 155 μl of supernatant are recovered. 150 μl are incubated for denaturation for 5 min at 95° C. in the presence of 4× NuPAGE LDS Sample Buffer diluted 4-fold (InVitrogen ref NP0007) and of 10× NuPAGE Sample Reducing Agent diluted 10-fold (InVitrogen ref NP0009). These samples are then frozen at −20° C. 5 μl are assayed by the microBCA technique according to the technical bulletin of the MicroBCA Protein Assay Kit (Pierce #23235). 
     For protein separation, 20 μg of proteins are loaded on to a NU-PAGE 4-12% Bis Tris Gel 12 well (InVitrogen ref NP0322BOX) and the migration is carried out for 1 h 30 in 20× NU-PAGE MOPS SDS Running Buffer diluted 20-fold (InVitrogen ref NP0001), at 150 volts. 
     The gel is then transferred on to an Invitrolon PVDF membrane (Invitrogen #LC2007) permeabilised beforehand and for a few seconds in ethanol (Ethanol Fischer Scientific #E/0600DF/15). 
     The transfer is carried out in a Biorad tank at 30 volts overnight or at 60 volts for 3 hours, in the presence of 20× NUPAGE Transfer Buffer diluted 20-fold (InVitrogen ref NP0006). 
     The membrane is then saturated in saturating solution composed of TBS (10× Tris Buffered Saline, Sigma #T5912, diluted 10-fold), 0.1% Tween (Sigma #P5927) and 3% BSA (Bovine Albumin Serum Fraction V, Sigma #A4503) for 6 h after overnight transfer or else for 1 h after transfer for a period of 3 h. 
     The primary antibodies are diluted to 1000th for the anti-phospho AKT-Ser473 antibody (193H2, rabbit monoclonal, cat#4058 from Cell Signaling Technology Abcam), in saturating solution composed of PBS, 0.1% Tween 20 and 3% BSA, and then shaken overnight at 4° C. Two rinses for min in washing solution composed of TBS and 0.1% Tween 20 are carried out before hybridisation of the secondary antibodies. 
     The secondary antibodies are diluted 110000th for the rabbit anti-Mouse IgG HRP antibody (W402 Promega) and to 110000th for the goat anti-Rabbit IgG HRP antibody (W401 Promega) in saturating solution, and then shaken for 1 h at ambient temperature. 
     Two rinses for 30 min in washing solution are carried out and then a rinse for 5 min in H 2 O is carried out in order to eliminate the remaining Tween 20. 
     The revealing solution is prepared volume-for-volume according to the technical bulletin of the Western Lightning Chemiluminescence Reagent Plus (Western Lightning Chemiluminescence Reagent Plus Perkin Elmer #NEL104). 
     The membrane is placed in the revealing solution for 1 min, drained, inserted between two transparent plates and then placed in the measuring device for reading the luminescence and the quantification of the signal. The luminescence is read with the FujiFilm device (Ray Test). 
     The FUJI device measures the total luminescence signal obtained (AU) for each band selected. It then subtracts the background noise (BG) proportional to the size of the band selected (Area), said background noise being calculated from a specific background noise band, with a view to obtaining the specific signal (AU-BG) for each band. The band obtained in the absence of product and in the presence of 0.1% DMSO is considered to be the 100% signal. The software calculates the % specific activity (Ratio) obtained for each band selected as a function of this 100% signal. The percentage inhibition is calculated for each concentration according to the formula (100%−Ratio). 
     Two independent experiments make it possible to calculate the mean of the percentages of inhibition obtained at a given concentration for the products tested only at one concentration. 
     Where appropriate, the activity of the products is translated into approximately IC50, obtained from a dose-response curve of various concentrations tested and representing the dose giving 50% of specific inhibition (absolute IC50). Two independent experiments make it possible to calculate the mean of the IC50s. 
     Study of pAKT Expression in PC3 Human Prostate Carcinoma Cells Measured by the MSD Multi-Spot Biomarker Detection Technique from Meso Scale Discovery (Test B): 
     This test is based on measuring the expression of the AKT protein phosphorylated on serine 473 (P-AKT-S473), in the PC3 human prostate carcinoma line, by means of the technique based on a sandwich immunoassay using the MSD Multi-spot Biomarker Detection kit from Meso Scale Discovery: phospho-Akt (Ser473) whole cell lysate kit (#K151CAD) or phospho-Akt (Ser473)/Total Akt whole cell lysate kit (#K15100D). The primary antibody specific for P-AKT-S473 (Kit #K151CAD) is coated on to an electrode in each well of the 96-well plates of the MSD, kit: after the addition of a protein lysate to each well, the signal is visualised by adding a secondary detection antibody labelled with an electrochemoluminescent compound. The procedure followed is that described in the kit. 
     On day 1, the PC3 cells are seeded into 96-well plates (TPP, #92096) at the concentration of 35 000 cells/well in 200 μl of DMEM medium (DMEM Gibco #11960-044) containing 10% of foetal calf serum (FCS Gibco, #10500-056) and 1% glutamine (L-Glu Gibco #25030-024), and incubated at 37° C., 5% CO 2 , overnight. 
     On day 2, the cells are incubated in the presence or absence of the test products for 1 to 2 h at 37° C. in the presence of 5% of CO 2 . The molecules, diluted in dimethyl sulphoxide (DMSO Sigma #D2650), are added from a 20-times concentrated stock solution, the final percentage of DMSO being 0.1%. The molecules are tested either at a single concentration of less than or equal to 10 μM, or at increasing concentrations in a range that can extend from less than 1 nM to 10 μM. 
     After this incubation, the cells are lysed for the preparation of the proteins. For this, after the culture medium has been drawn off, 50 μl of complete Tris Lysis Buffer of the MSD kit containing the protease and phosphatase inhibitor solutions are added to the wells and the cells are lysed for 1 h at 4° C. with shaking. At this stage, the plates containing the lysates can be stored at −20° C. or at −80° C. 
     The wells of the 96-well plates of the MSD kit are saturated for 1 h at ambient temperature with the blocking solution of the MSD kit. Four washes are carried out with 150 μl of Tris Wash Buffer of the MSD kit. The lysates previously prepared are transferred into the 96-well multi-spot plates of the MSD kit and incubated for 1 h at ambient temperature, with shaking. Four washes are carried out with 150 μl of Tris Wash Buffer of the MSD kit. 25 μl of the MSD sulfo-tag detection antibody solution are added to the wells and incubated for 1 h at ambient temperature, with shaking. Four washes are carried out with 150 μl of Tris Wash Buffer of the MSD kit. 150 μl of Read Buffer of the MSD kit are added to the wells and the plates are read immediately on the S12400 instrument from Meso Scale Discovery. 
     The instrument measures a signal for each well. Wells without cells and containing the lysis buffer serve to determine the background noise that will be subtracted from all the measurements (min). The wells containing cells in the absence of product and in the presence of 0.1% DMSO are considered to be the 100% signal (max). The percentage inhibition is calculated for each concentration of test product according to the following formula: (1-((test-min)(max-min)))×100. 
     The activity of the product is translated to IC 50 , obtained from a dose-response curve of various concentrations tested and representing the dose giving 50% specific inhibition (absolute IC 50 ). 2 independent experiments make it possible to calculate the mean of the IC 50  values. 
     The results obtained for the products as examples in the experimental section are given in the pharmacological results table below: 
     Pharmacological Results Table: 
     
       
         
           
               
               
               
               
             
               
                   
                   
               
               
                   
                 example 
                 Test A 
                 Test B 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Example 1 
                 102 
                   
               
               
                   
                 Example 2 
                 321 
                   
               
               
                   
                 Example 3 
                 100 
                   
               
               
                   
                 Example 4 
                   
                 145 
               
               
                   
                 Example 5 
                   
                 51 
               
               
                   
                 Example 6 
                 23 
                   
               
               
                   
                 Example 7 
                   
                 23 
               
               
                   
                 Example 8  
                 318 
                   
               
               
                   
                 Example 9  
                 727 
                   
               
               
                   
                 Example 10 
                 3498 
                   
               
               
                   
                 Example 11 
                 632 
                   
               
               
                   
                 Example 12 
                 737 
                   
               
               
                   
                 Example 13 
                   
                 71 
               
               
                   
                 Example 14 
                 570 
                 74 
               
               
                   
                 Example 15 
                 1420 
                   
               
               
                   
                 Example 16 
                 850 
                   
               
               
                   
                 Example 17 
                 1481 
                   
               
               
                   
                 Example 18  
                 23 
                   
               
               
                   
                 Example 19 
                   
                 42 
               
               
                   
                 Example 20 
                 1314 
                   
               
               
                   
                 Example 21 
                 10 000 
                   
               
               
                   
                 Example 22 
                 350 
                   
               
               
                   
                 Example 23  
                 39 
                   
               
               
                   
                 Example 24 
                   
                 247 
               
               
                   
                 Example 25 
                   
                   
               
               
                   
                 Example 26 
                 2287 
                   
               
               
                   
                 Example 27 
                   
                 71 
               
               
                   
                 Example 28  
                 171 
                   
               
               
                   
                 Example 29  
                 116 
                   
               
               
                   
                 Example 30 
                   
                 1030 
               
               
                   
                 Example 31 
                   
                 58 
               
               
                   
                 Example 32 
                 3635 
                   
               
               
                   
                 Example 33  
                 93 
                   
               
               
                   
                 Example 34  
                 609 
                   
               
               
                   
                 Example 35 
                 10 000 
                   
               
               
                   
                 Example 36  
                 200 
                   
               
               
                   
                 Example 37 
                 10 000 
                   
               
               
                   
                 Example 38  
                 480 
                   
               
               
                   
                 Example 39  
                 1763 
                   
               
               
                   
                 Example 40  
                 1494 
                   
               
               
                   
                 Example 41  
                 290 
                 60 
               
               
                   
                 Example 42  
                 400 
                 148 
               
               
                   
                 Example 43  
                 549 
                   
               
               
                   
                 Example 44  
                 308 
                   
               
               
                   
                 Example 45  
                 261 
                   
               
               
                   
                 Example 46 
                 2498 
                   
               
               
                   
                 Example 47  
                 346 
                   
               
               
                   
                 Example 48  
                 184 
                   
               
               
                   
                 Example 49 
                   
                 146 
               
               
                   
                 Example 50  
                 6721 
                   
               
               
                   
                 Example 51  
                 133 
                   
               
               
                   
                 Example 52  
                 227 
                   
               
               
                   
                 Example 53 
                   
                 66 
               
               
                   
                 Example 54  
                 807 
                 67 
               
               
                   
                 Example 55 
                 10 000 
                   
               
               
                   
                 Example 56 
                 137 
                   
               
               
                   
                 Example 57  
                 5865 
                   
               
               
                   
                 Example 58  
                 760 
                 71 
               
               
                   
                 Example 59  
                 417 
                 50 
               
               
                   
                 Example 60 
                   
                 290 
               
               
                   
                 Example 61 
                   
                 77 
               
               
                   
                 Example 62  
                 530 
                   
               
               
                   
                 Example 63  
                 6155 
                   
               
               
                   
                 Example 64 
                   
                 10 000 
               
               
                   
                 Example 65  
                 6460 
                   
               
               
                   
                 Example 66 
                   
                 131 
               
               
                   
                 Example 67 
                 2207 
                   
               
               
                   
                 Example 68 
                 202 
                 79 
               
               
                   
                 Example 69 
                 250 
                   
               
               
                   
                 Example 70 
                   
                 195 
               
               
                   
                 Example 71 
                 5375 
                 120 
               
               
                   
                 Example 72 
                   
                 89 
               
               
                   
                 Example 73 
                 650 
                   
               
               
                   
                 Example 74 
                   
                 10 
               
               
                   
                 Example 75 
                   
                 69 
               
               
                   
                 Example 76 
                   
                 77 
               
               
                   
                 Example 77 
                   
                 698 
               
               
                   
                 Example 78 
                   
                 129 
               
               
                   
                 Example 79 
                   
                 20 
               
               
                   
                 Example 80 
                   
                 94 
               
               
                   
                 Example 81 
                   
                 1940 
               
               
                   
                 Example 82 
                   
                 133 
               
               
                   
                 Example 83 
                   
                 115 
               
               
                   
                 Example 84 
                   
                 17 
               
               
                   
                 Example 85 
                   
                 340 
               
               
                   
                 Example 86 
                   
                 26 
               
               
                   
                 Example 87 
                   
                 75 
               
               
                   
                 Example 88 
                   
                 5 
               
               
                   
                 Example 89 
                   
                 3 
               
               
                   
                 Example 90 
                   
                 14 
               
               
                   
                 Example 91 
                   
                 71 
               
               
                   
                 Example 92 
                   
                 57 
               
               
                   
                 Example 93 
                   
                 63 
               
               
                   
                 Example 94 
                   
                 11 
               
               
                   
                 Example 95 
                   
                 35 
               
               
                   
                 Example 96 
                   
                 6 
               
               
                   
                 Example 97 
                   
                 260 
               
               
                   
                 Example 98 
                   
                 219 
               
               
                   
                 Example 99  
                   
                 666 
               
               
                   
                 Example 100 
                   
                 3 
               
               
                   
                 Example 101 
                   
                 13 
               
               
                   
                 Example 102 
                   
                 43 
               
               
                   
                 Example 103 
                   
                 7 
               
               
                   
                 Example 104 
                   
                 42 
               
               
                   
                 Example 105 
                   
                 15 
               
               
                   
                 Example 106 
                   
                 27 
               
               
                   
                 Example 107 
                   
                 24 
               
               
                   
                 Example 108 
                   
                 56 
               
               
                   
                 Example 109 
                   
                 43 
               
               
                   
                 Example 110 
                   
                 278 
               
               
                   
                 Example 111 
                   
                 301 
               
               
                   
                 Example 112 
                   
                 23 
               
               
                   
                 Example 113 
                   
                 664 
               
               
                   
                 Example 114 
                   
                 26 
               
               
                   
                 Example 115 
                   
                 10 
               
               
                   
                 Example 116 
                   
                 51 
               
               
                   
                 Example 117 
                   
                 19 
               
               
                   
                 Example 118 
                   
                 12 
               
               
                   
                 Example 119 
                   
                 194 
               
               
                   
                 Example 120 
                   
                 11 
               
               
                   
                 Example 121 
                   
                 44 
               
               
                   
                 Example 122 
                   
                 503 
               
               
                   
                 Example 123 
                   
                 77 
               
               
                   
                 Example 124 
                   
                 124 
               
               
                   
                 Example 125 
                   
                 16 
               
               
                   
                 Example 126 
                   
                 57 
               
               
                   
                 Example 127 
                   
                 61 
               
               
                   
                 Example 128 
                   
                 69 
               
               
                   
                 Example 129 
                   
                 1000 
               
               
                   
                 Example 130 
                   
                 70 
               
               
                   
                 Example 131 
                   
                 41 
               
               
                   
                 Example 132 
                   
                 533 
               
               
                   
                 Example 133 
                   
                 174 
               
               
                   
                 Example 134 
                   
                 124 
               
               
                   
                 Example 135 
                   
                 1 
               
               
                   
                 Example 136 
                   
                 26 
               
               
                   
                 Example 137 
                   
                 68 
               
               
                   
                 Example 138 
                   
                 35 
               
               
                   
                 Example 139 
                   
                 3000 
               
               
                   
                 Example 140 
                   
                 302 
               
               
                   
                 Example 141 
                   
                 60 
               
               
                   
                 Example 142 
                   
                 22 
               
               
                   
                 Example 143 
                   
                 473 
               
               
                   
                 Example 144 
                   
                 432 
               
               
                   
                 Example 145 
                   
                 38 
               
               
                   
                 Example 146 
                   
                 180 
               
               
                   
                 Example 147 
                   
                 4 
               
               
                   
                 Example 148 
                   
                 234 
               
               
                   
                 Example 149 
                   
                 43 
               
               
                   
                 Example 150 
                   
                 189 
               
               
                   
                 Example 151 
                   
                 29 
               
               
                   
                 Example 152 
                   
                 938 
               
               
                   
                 Example 153 
                   
                 49 
               
               
                   
                 Example 154 
                   
                 28 
               
               
                   
                   
               
               
                   
                 Tests A and B: IC 50  (nM)