Patent Publication Number: US-2010122382-A1

Title: Cell Cycle Genes and Related Methods

Description:
CROSS REFERENCE TO RELATED APPLICATION 
     This application claims priority to U.S. provisional application Ser. No. 60/533,036, filed on Dec. 30, 2003, which is specifically incorporated in its entirety herein by reference. 
    
    
     FIELD OF THE INVENTION 
     The present invention relates generally to the field of plant cell cycle genes and polypeptides encoded by such genes, and the use of such polynucleotide and polypeptide sequences for regulating a plant cell cycle. The invention specifically provides cell cycle polynucleotide and polypeptide sequences isolated from  Eucalyptus  and  Pinus  and sequences related thereto. 
     BACKGROUND OF THE INVENTION 
     Cell growth and division are controlled by the temporal expression of different sets of genes, allowing the dividing cell to progress through the different phases of the cell cycle. Continued growth and organogesis in plants requires precise function of the cell cycle machinery. Plant development, which is directly affected by cell division rates and patterns, also is influenced by environmental factors, such as temperature, nutrient availability, light, etc. See Gastal and Nelon,  Plant Physiol.  105:191-7 (1994), Ben-Haj-Sahal and Tardieu,  Plant Physiol.  109:861-7 (1995), and Sacks et al.,  Plant Physiol.  114:519-27 (1997). Plant development and phenotype are connected with the cell cycle, and altering expression of the genes involved in the cell cycle can be a useful method of modifying plant development and altering plant phenotype. 
     The ability to alter expression of cell cycle genes is extremely powerful because the cell cycle drives plant development, including growth rates, responses to environmental cues, and resulting plant phenotype. Control of the plant cell cycle and phenotypes associated with alteration of cell cycle gene expression, in the vascular cambium, in particular, has applications for, inter alia, alteration of wood properties and, in particular, lumber and wood pulp properties. For example, improvements to wood pulp that can be effected by altering cell cycle gene expression include increased or decreased lignin and cellulose content, and altered length, diameter, and lumen diameter of cells. Manipulating the plant cell cycle, and in particular the cambium cell cycle (i.e. the rate and angle of cell division), can also engineer better lumber having increased dimensional stability, increased tensile strength, increased shear strength, increased compression strength, increased shock resistance, increased stiffness, increased or decreased hardness, decreased spirality, decreased shrinkage, and desirable characteristics with respect to weight, density, and specific gravity. 
     A. Cell Cycle Genes and Proteins 
     1. Cyclin Dependent Protein Kinase 
     Progression through the cell cycle is regulated primarily by cyclin-dependent kinases (CDKs). CDKs are a conserved family of eukaryotic serine/threonine protein kinases, which require heterodimer formation with a cyclin subunit for activity. For review see, e.g. Joubes et al.,  Plant Mol. Biol.  43: 607-20 (2000), Stals and Inze, Trends Plant Sci. 6:359-64 (2001), and John et al.,  Protoplasma  216: 119-42 (2001). 
     The are five subclasses of CDK&#39;s, each having a different cyclin binding consensus sequence. In CDK type A the cyclin binding consensus sequence is PSTAIRE. Id. The cyclin binding consensus sequence in CDK types B-1, B-2, and C are PPTTLRE, PPTALRE, and PITAIRE, respectively. Joubes et al,  Plant Physiol,  126: 1403-15 (2001). 
     Cell cycle progression is directed, in part, by changes in CDK activity. CDK activity is modulated by a number of different cell cycle protein components, such as changes in the abundance of individual cyclins due to changing rates of biosynthesis and proteolysis. Fluctuations in cyclin concentrations result in commensurate fluctuations in CDK activity. Cyclin accumulation is especially important in terminating the G1 phase of the cell cycle because DNA replication is initiated by an increase in CDK activity. 
     Activation of CDK also requires phosphorylation of a threonine residue within the T-loop of CDK by a CDK-activating kinase (CAK). Umeda et al.,  Proc. Nat&#39;l Acad. Sci. U.S.A.  97: 13396-400 (2000). It was suggested by Yamaguchi et al.,  Plant J.  24: 11-20 (2000), that cyclin H is a regulatory subunit of CAK. CDK activity is further regulated by interaction with a CDK regulatory subunit, a small (70-100 AA) protein involved in cell cycle regulation. 
     A cell must exit the cell cycle in order to commit to differentiation, senescence or apoptosis. This process involves the down-regulation of CDK activities. CDK inhibitors (CKI) are low molecular weight proteins, which are important for cell cycle regulation and development. CKIs bind stoichiometrically to CDK and down-regulate the activity of CDKs. 
     Many biochemical properties of ICK1, the first plant CKI to be identified from  Arabidopsis thaliana,  are known. Wang et al.,  Nature  386:451-2 (1997) Wang et al.,  Plant J.  24: 613-23 (2000). ICK1 is expressed at low levels in many tissue types, and there can be a threshold level of ICK1 that must be overcome before a cell can enter the cell cycle. Wang et al.,  Plant J.  24: 613-23 (2000). ICK1 is induced by the plant growth regulator abscisic acid (ABA), which inhibits cell division by blocking DNA replication. When the expression of ICK1 increases, there is a corresponding decrease in Cdc2-like H1 histone activity. ICK1 has been shown to bind in vitro with the cyclins C2c2a and CycD3, and deletion experiments have identified different domain regions for these two interactions. 
     Altering the expression of CDK regulatory protein or a subunit thereof is known to cause changes in plant phenotype. Overexpression of the  Arabidopsis  CDK regulatory subunit, CKS1At, resulted in a reduction of leaf size, root growth rates and meristem size. Additionally, overexpression of CKS1At resulted in inhibition of cell-cycle progression, with an extension in the duration of the G1 and G2 phases of the cell cycle. 
     2. Cyclins 
     Cyclins are positive regulatory subunits of cyclin-dependent kinase (CDK) enzymes and are required for CDK activity. Fowler et al.,  Mol. Biotech.  10, 123, 126. Cyclins and CDK complexes provide temporal regulation of transition through the cell cycle. Evidence also suggests that cyclins provide spatial regulation of specific CDK activity, differentially targeting the cytoskeleton, spindle, phragmoplast, nuclear envelope, and chromosomes. 
     Plant cyclins are classified into five major groups: A, B, C, D, and H. Renaudin et al.,  Plant Mol. Biol.  32: 1003-18 (1996) and Yamaguchi et al., (supra 2000). Cyclins can be divided into mitotic cyclins (A and B) and G 1  cyclins. 
     The mitotic cyclins possess a consensus sequence (R-x-x-L-x-x-I-x-N) located at the N-terminal region, termed a destruction box, adjacent to a lysine-rich region. The destruction box and lysine-rich region target the mitotic cyclins for ubiquitin-dependent proteolysis during mitosis. Stals, supra at 361, and Fowler, supra at 126. The destruction box in A versus B cyclins differs slightly and this difference is thought to result in slightly different timing of degradation of A versus B cyclins. Fowler, supra at 126. A-type cyclins accumulate during the S, G2, and early M phase of the cell cycle, whereas B-type cyclins accumulate during the late G2 and early M phase. Mironov et al.,  Plant Cell  11: 509-22 (1999). Three subgroups of A-type cyclins are known in plants, but only one is known in animals. Cyclin A1 (cycA1;zm;1 from  Zea cans ) is most concentrated during cytokinesis at the microtubule-containing phragmoplast. Expression of cyclin A2 is upregulated by auxins in roots, and by cytokinins in the shoot apex. Abrahams et al.,  Biochim. Biophys. Acta  28: 1-2 (2001). 
     D-type cyclins, of which five subgroups are known, are thought to control the progression through the G1 phase in response to growth factors and nutrients. Riou-Khamlichi et al.,  Mol. Cell Biol.  20: 4513-21 (2000). For example, the expression of D-type cyclins is upregulated by sucrose as shown by an increase in cycD2 mRNA 30 minutes after sucrose exposure, and an increase in cycD3 four hours after sucrose exposure. This timing corresponds to early G1-phase and late G1-phase, respectively. Cockcroft et al.,  Nature  405: 575-9 (2000). Furthermore, in  Arabidopsis,  a D3 cyclin was shown to be upregulated by the brassinosteroid, epi-brassinolide. 
     Cyclin D2 proteins bind with CDKA to produce an active complex, which binds to and phosphorylates retinoblastoma-related protein (Rb). This process is found in actively proliferating tissue, suggesting it plays an important function during late G1- and early S-phase. Three different D3-type cyclins are active during tomato fruit development. These proteins all contain a retinoblastoma binding motif and a PEST-destruction motif. There are differences in the spatial and temporal expression of these D3 cyclins, inferring different roles during fruit development. 
     Overexpression of cyclin D was shown to increase overall growth rate. Over-expression of cyclin D2 in tobacco increases causes shortening the G1-phase which producing a faster rate of cell cycling. 
     C- and H-type cyclins were characterized in poplar ( Populus tremula×tremuloides ) and rice ( Oryza sativa ) but their exact function is still unclear. Putative cyclins with a lesser degree of peptide sequence conservation have also been identified. For example,  Arabidopsis  CycJ18 has only 20% identity with homologues over the cyclin box domain. CycJ18 is expressed predominantly in young seedlings.  Arabidopsis  F3O9.13 protein also has similarity to the cyclin family. 
     3. Histone Acetyltransferase/Deacetyltransferase 
     Histone acetyltransferase (HA) and histone deacetyltransferase (HAD) control the net level of acetylation of histones. Histone acetylation and deacetylation are thought to exert their regulatory effects on gene expression by altering the accessibility of nucleosomal DNA to DNA-binding transcriptional activators, other chromatin-modifying enzymes or multi-subunit chromatin remodeling complexes capable of displacing nucleosomes. Lusser et al.,  Nucleic Acids Res.  27: 4427-35 (1999). Therefore, in general, the HDAs are involved in the repression of gene expression, while HAs are correlated with gene activation. 
     HA effects acetylation at the ε-amino group of conserved lysine residues clustered near the amino terminus of core histones which up-regulates gene expression. 
     HDAs remove acetyl groups from the core histones of the nucleosome. There are numerous family members in the HDA group, many of which are conserved throughout evolution. Lechner et al.,  Biochim Biophys Acta  5:181-8 (1996). HDAs function as part of multi-protein complexes facilitating chromatin condensation. 
     HDAs and HAs recognize highly distinct acetylation patterns on the nucleosome. It is thought that different types of HDAs interact with specific regions of the genome, to influence gene silencing. 
     Schultz et al.,  Genes Dev.  15: 428-43 (2001), demonstrated that the superfamily of Kruppel-associated-box zinc finger proteins (KRAB-ZFPs) are linked to the nucleosome remodeling and histone deacetylation complex via the PHD (plant homeodomain) and bromodomains of co-repressor KAP-1, to form a cooperative unit that is required for transcriptional repression. A maize HDAC (HD2) has been identified that has no sequence homology to other eukaryotic HDACs, but instead contains sequence similarity to peptidyl-prolyl cis-trans isomerases (PPIases). 
     The effects of interfering with histone deacetylation are discussed in e.g. Tian and Chen,  Proc. Nat&#39;l Acad. Sci. USA  98: 200-5 (2001). 
     4. Peptidyl Prolyl Cis-Trans Isomerase 
     Peptidylprolyl isomerases (e.g., peptidylprolyl cis-trans isomerase, peptidyl-prolyl cis-trans isomerase, PPIase, rotamase, cyclophilin) catalyze the interconversion of peptide bonds between the cis and trans conformations at proline residues. Sheldon and Venis,  Biochem J.  315: 965-70 (1996). This interconversion is thought to be the rate limiting step of protein folding. PPIases belong to a conserved family of proteins that are present in animals, fungi, bacteria and plants. PPIases are implicated in a number of responses including the response to environmental stress, calcium signals, transcriptional repression, cell cycle control, etc. Viaud, et al.,  Plant Cell  14: 917-30 (2002). 
     5. Retinoblastoma-Related Protein 
     Retinoblastoma (Rb)-related protein putatively regulates progression of the cell cycle through the G1 phase and into S phase. Xie et al.,  EMBO J.  15: 4900-8 (1996) and Ach et al.,  Mol. Cell Biol.  17: 5077-86 (1997). 
     Although Rb is well-characterized in mammalian systems, the role of Rb-related proteins in regulation of G1 phase progression and S phase entry is not well characterized in plants. It is known, however, that RB-related protein functions through its association with various other cellular proteins involved in cell cycle regulation, such as the cyclins, WD40 proteins, Soni et al.,  Plant. Cell.  7:85-103 (1995); Grafi et al.,  Proc. Natl. Acad. Sci. U.S.A.  93:8962 (1996); Ach et al.,  Plant Cell  9:1595-606 (1997); Umen and Goodenough,  Genes Dev.  15:1652-61 (2001); Mariconti et al.,  J. Biol. Chem.  277:9911-9 (2002). 
     6. WD40 Repeat Protein 
     WD40 is a common repeating motif involved in many different protein-protein interactions. The WD40 domain is found in proteins having a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. Goh et al.,  Eur. J. Biochem.  267: 434-49 (2000). 
     The WD40 domain, which is 40 residues long, typically contains a GH dipeptide 11-24 residues from the N-terminus and the WD dipeptide at the C-terminus. Id. Between the GH dipeptide and the WD dipeptide lies a conserved core which serves as a stable platform where proteins can bind either stably or reversibly. The core forms a propeller-like structure with several blades. Each blade is composed of a four-stranded anti-parallel β-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands. 
     Studies in yeast demonstrated that Cdc20, which contains the WD40 motif, is required for the proteolysis of mitotic cyclins. This process is mediated by an ubiquitin-protein ligase called anaphase-promoting complex (APC) or cyclosome. Following ubiquitination and proteolysis by the 26S proteasome, the cell can segregate chromosomes, and exit from mitosis. Cdc20 also contains a destruction-box domain. 
     7. WEE1-Like Protein 
     WEE1 controls the activity of cyclin-dependent kinases. WEE1 itself is a serine/threonine kinase. Sorrell et al.,  Planta  215: 518-22 (2002). The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation segment of the catalytic domain, sometimes combined with reversible conformational changes in the C-terminal autoregulatory tail. This process is conserved among eukaryotes, from fungi to animals and plants. Similarly, there is a high degree of homology between WEE1 proteins from various organisms. For example, there is 50% identity between the protein kinase domains of the human and maize WEE1 proteins. 
     Expression of WEE1 is shown to occur only in actively dividing tissues and is believed to inhibit cell division by acting as a negative regulator of mitosis. WEE1 is believed to prevent entry from G2 to M by protecting the nucleus from cytoplasmically-activated cyclin B1-complexed CDC2 before the onset of mitosis. For example, over-expression of AtWEE1 (from  Arabidopsis ) and ZmWEE1 (from  Zea cans ) in fission yeast inhibits cell division which results in elongated cells. Sun et al.,  Proc. Nat&#39;l Acad. Sci. USA  96: 4180-5 (1999). 
     B. Expression Profiling and Microarray Analysis in Plant Development 
     The multigenic control of plant phenotype presents difficulties in determining the genes responsible for phenotypic determination. One major obstacle to identifying genes and gene expression differences that contribute to phenotype in plants is the difficulty with which the expression of more than a handful of genes can be studied concurrently. Another difficulty in identifying and understanding gene expression and the interrelationship of the genes that contribute to plant phenotype is the high degree of sensitivity to environmental factors that plants demonstrate. 
     There have been recent advances using genome-wide expression profiling. In particular, the use of DNA microarrays has been useful to examine the expression of a large number of genes in a single experiment. Several studies of plant gene responses to developmental and environmental stimuli have been conducted using expression profiling. For example, microarray analysis was employed to study gene expression during fruit ripening in strawberry, Aharoni et al.,  Plant Physiol.  129:1019-1031 (2002), wound response in  Arabodopsis,  Cheong et al.,  Plant Physiol.  129:661-7 (2002), pathogen response in  Arabodopsis,  Schenk et al.,  Proc. Nat&#39;l Acad. Sci.  97:11655-60 (2000), and auxin response in soybean, Thibaud-Nissen et al.,  Plant Physiol.  132:118. Whetten et al.,  Plant Mol. Biol.  47:275-91 (2001) discloses expression profiling of cell wall biosynthetic genes in  Pinus taeda  L. using cDNA probes. Whetten et al. examined genes which were differentially expressed between differentiating juvenile and mature secondary xylem. Additionally, to determine the effect of certain environmental stimuli on gene expression, gene expression in compression wood was compared to normal wood. 156 of the 2300 elements examined showed differential expression. Whetten, supra at 285. Comparison of juvenile wood to mature wood showed 188 elements as differentially expressed. Id. at 286. 
     Although expression profiling and, in particular, DNA microarrays provide a convenient tool for genome-wide expression analysis, their use has been limited to organisms for which the complete genome sequence or a large cDNA collection is available. See Hertzberg et al.,  Proc. Nat&#39;l Acad. Sci.  98:14732-7 (2001a), Hertzberg et al.,  Plant J.,  25:585 (2001b). For example, Whetten, supra, states, “A more complete analysis of this interesting question awaits the completion of a larger set of both pine and poplar ESTs.” Whetten et al. at 286. Furthermore, microarrays comprising cDNA or EST probes may not be able to distinguish genes of the same family because of sequence similarities among the genes. That is, cDNAs or ESTs, when used as microarray probes, may bind to more than one gene of the same family. 
     Methods of manipulating gene expression to yield a plant with a more desirable phenotype would be facilitated by a better understanding of cell cycle gene expression in various types of plant tissue, at different stages of plant development, and upon stimulation by different environmental cues. The ability to control plant architecture and agronomically important traits would be improved by a better understanding of how cell cycle gene expression effects formation of plant tissues, how cell cycle gene expression causes plant cells to enter or exit cell division, and how plant growth and the cell cycle are connected. Among the large number of genes, the expression of which can change during development of a plant, only a fraction are likely to effect phenotypic changes during any given stage of the plant development. 
     SUMMARY 
     Accordingly, there is a need for tools and methods useful in determining the changes in the expression of cell cycle genes that occur during the plant cell cycle. There is also a need for polynucleotides useful in such methods. There is a further need for methods which can correlate changes in cell cycle gene expression to phenotype or stage of plant development. There is a further need for methods of identifying cell cycle genes and gene products that impact plant phenotype, and that can be manipulated to obtain a desired phenotype. 
     In one aspect, the present invention provides an isolated polynucleotide comprising a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237 and conservative variants thereof. 
     In another aspect, the present invention provides a DNA construct comprising at least one polynucleotide having the sequence of any one of SEQ ID NOs: 1-237 and conservative variants thereof. 
     Another aspect of the invention is a plant cell transformed with a DNA construct of comprising a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237 and conservative variants thereof. 
     A further aspect of the invention is a transgenic plant comprising a plant cell transformed with a DNA construct comprising a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237 and conservative variants thereof. 
     Another aspect of the invention is an isolated polynucleotide comprising a sequence encoding the catalytic or substrate-binding domain of a polypeptide selected from of any one of SEQ ID NOs: 261-497, wherein the polynucleotide encodes a polypeptide having the activity of said polypeptide selected from any one of SEQ ID NOs: 261-497. 
     A further aspect of the invention is a method of making a transformed plant comprising transforming a plant cell with a DNA construct comprising at least one polynucleotide having the sequence of any of SEQ ID NOs: 1-237; and culturing the transformed plant cell under conditions that promote growth of a plant. 
     In another aspect, the invention provides a wood obtained from a transgenic tree. 
     In a further aspect, the invention provides a wood pulp obtained from a transgenic tree which has been transformed with the DNA construct of the invention. 
     Another aspect of the invention is a method of making wood, comprising transforming a plant with a DNA construct comprising a polynucleotide having a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237 and conservative variants thereof; culturing the transformed plant under conditions that promote growth of a plant; and obtaining wood from the plant. 
     The invention further provides a method of making wood pulp, comprising transforming a plant with a DNA construct comprising a polynucleotide having a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237 and conservative variants thereof; culturing the transformed plant under conditions that promote growth of a plant; and obtaining wood pulp from the plant. 
     In another aspect, the invention provides an isolated polypeptide comprising an amino acid sequence encoded by the isolated polynucleotide comprising a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237 and conservative variants thereof. 
     The invention also provides, an isolated polypeptide comprising an amino acid sequence selected from the group consisting of 261-497. 
     The invention further provides a method of altering a plant phenotype of a plant, comprising altering expression in the plant of a polypeptide encoded by any one of SEQ ID NOs: 1-237. 
     In another aspect, the invention provides a polynucleotide comprising a nucleic acid selected from the group comprising of SEQ ID NOs: 471-697. 
     An aspect of the invention is a method of correlating gene expression in two different samples, comprising detecting a level of expression of one or more genes encoding a product encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237 and conservative variants thereof in a first sample; detecting a level of expression of the one or more genes in a second sample; comparing the level of expression of the one or more genes in the first sample to the level of expression of the one or more genes in the second sample; and correlating a difference in expression level of the one or more genes between the first and second samples. 
     A further aspect of the invention is a method of correlating the possession of a plant phenotype to the level of gene expression in the plant of one or more genes comprising detecting a level of expression of one or more genes encoding a product encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237 and conservative variants thereof in a first plant possessing a phenotype; detecting a level of expression of the one or more genes in a second plant lacking the phenotype; comparing the level of expression of the one or more genes in the first plant to the level of expression of the one or more genes in the second plant; and correlating a difference in expression level of the one or more genes between the first and second plants to possession of the phenotype. 
     In a further aspect, the invention provides a method of correlating gene expression to a stage of the cell cycle, comprising detecting a level of expression of one or more genes encoding a product encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237 and conservative variants thereof in a first plant cell in a first stage of the cell cycle; detecting a level of expression of the one or more genes in a second plant cell in a second, different stage of the cell cycle; comparing the level of the expression of the one or more genes in the first plant cells to the level of expression of the one or more genes in the second plants cells; and correlating a difference in expression level of the one or more genes between the first and second samples to the first or second stage of the cell cycle. 
     An aspect of the invention is a combination for detecting expression of one or more genes, comprising two or more oligonucleotides, wherein each oligonucleotide is capable of hybridizing to a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237. 
     Another aspect of the invention is a combination for detecting expression of one or more genes, comprising two or more oligonucleotides, wherein each oligonucleotide is capable of hybridizing to a nucleic acid sequence encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237. 
     The invention further provides a microarray comprising a combination for detecting expression of one or more genes, comprising two or more oligonucleotides, wherein each oligonucleotide is capable of hybridizing to a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237 or wherein each oligonucleotide is capable of hybridizing to a nucleic acid sequence encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237, wherein each of said two or more oligonucleotides occupies a unique location on said solid support. 
     In another aspect, the invention provides a method for detecting one or more genes in a sample, comprising contacting the sample with two or more oligonucleotides, wherein each oligonucleotide is capable of hybridizing to a gene comprising a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237 under standard hybridization conditions; and detecting the one or more genes of interest which are hybridized to the one or more oligonucleotides. 
     The invention also provides a method for detecting one or more nucleic acid sequences encoded by one or more genes in a sample, comprising contacting the sample with two or more oligonucleotides, wherein each oligonucleotide is capable of hybridizing to a nucleic acid sequence encoded by a gene comprising a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-237 under standard hybridization conditions; and detecting the one or more nucleic acid sequences which are hybridized to the one or more oligonucleotides. 
     The invention further provides a kit for detecting gene expression comprising the microarray of the invention together with one or more buffers or reagents for a nucleotide hybridization reaction. 
     Other features, objects, and advantages of the present invention are apparent from the detailed description that follows. It should be understood, however, that the detailed description, while indicating preferred embodiments of the invention, are given by way of illustration only, not limitation. Various changes and modifications within the spirit and scope of the invention will be apparent to those skilled in the art from the detailed description. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1 : Exemplary microarray sampling parameters. 
         FIG. 2 : Plasmid map for pWVK202. 
         FIG. 3 : Plasmid map for pGrowth14. 
         FIG. 4 : Plasmid map for pGrowth15. 
         FIG. 5 : Plasmid map for pGrowth16. 
         FIG. 6 : Plasmid map for pGrowth18. 
         FIG. 7 : Plasmid map for pGrowth19. 
         FIG. 8 : Plasmid map for pGrowth20. 
     
    
    
     LIST OF TABLES 
     Table 1: shows genes having greater than doubled signal with any one sample as compared to the mean signal of the other three samples. 
     Table 2: identifies plasmid(s), genes, and Genesis ID numbers for constructs described in Example 17. 
     Table 3: Rooting medium for  Populus deltoids.    
     Table 4: pGrowth information. 
     Table 5: shows genes having greater than doubled signal with any one sample as compared to the mean signal of the other three samples. 
     Table 6: Differentially expressed cDNAs. 
     Table 7: Consensus ID information. 
     Table 8: pGrowth information. 
     Table 9:  Eucalyptus grandis  cell cycle genes and proteins. 
     Table 10:  Pinus radiata  cell cycle genes and proteins. 
     Table 11: Annotated peptide sequences of the present invention. 
     Table 12:  Eucalyptus  in silico data. 
     Table 13: Pine in silico data. 
     Table 14: Oligo table. 
     Table 15: Peptide table. 
     Table 16: BLAST sequence alignment table. 
     DETAILED DESCRIPTION 
     The inventors have discovered novel isolated cell cycle genes and polynucleotides useful for identifying the multigenic factors that contribute to a phenotype and for manipulating gene expression to affect a plant phenotype. These genes, which are derived from plants of commercially important forestry genera, pine and eucalyptus, are involved in the plant cell cycle and are, at least in part, responsible for expression of phenotypic characteristics important in commercial wood, such as stiffness, strength, density, fiber dimensions, coarseness, cellulose and lignin content, and extractives content. Generally speaking, the genes and polynucleotides encode a protein which can be a cyclin, cyclin dependent kinase, cyclin dependent kinase inhibitor, histone acetyltransferase, histone deacetylase, peptidyl-prolyl cis-trans isomerase, retinoblastoma-related protein, WEE1-like protein, or WD40 repeat protein, or a catalytic domain thereof, or a polypeptide having the same function, and the invention further includes such proteins and polypeptides. 
     The methods of the present invention for selecting cell cycle gene sequences to target for manipulation will permit better design and control of transgenic plants with more highly engineered phenotypes. The ability to control plant architecture and agronomically important traits in commercially important forestry species will be improved by the information obtained from the methods, such as which genes affect which phenotypes, which genes affect entry into which stage of the cell cycle, which genes are active in which stage of plant development, and which genes are expressed in which tissue at a given point in the cell cycle or plant development. 
     Unless indicated otherwise, all technical and scientific terms are used herein in a manner that conforms to common technical usage. Generally, the nomenclature of this description and the described laboratory procedures, including cell culture, molecular genetics, and nucleic acid chemistry and hybridization, respectively, are well known and commonly employed in the art. Standard techniques are used for recombinant nucleic acid methods, oligonucleotide synthesis, cell culture, tissue culture, transformation, transfection, transduction, analytical chemistry, organic synthetic chemistry, chemical syntheses, chemical analysis, and pharmaceutical formulation and delivery. Generally, enzymatic reactions and purification and/or isolation steps are performed according to the manufacturers&#39; specifications. Absent an indication to the contrary, the techniques and procedures in question are performed according to conventional methodology disclosed, for example, in Sambrook et al., M OLECULAR  C LONING  A L ABORATORY  M ANUAL,  2d ed. (Cold Spring Harbor Laboratory Press, 1989), and C URRENT  P ROTOCOLS IN  M OLECULAR  B IOLOGY,  John Wiley &amp; Sons, 1989). Specific scientific methods relevant to the present invention are discussed in more detail below. However, this discussion is provided as an example only, and does not limit the manner in which the methods of the invention can be carried out. 
     A. Plant Cell Cycle Genes and Proteins 
     1. Cell Cycle Genes, Polynucleotide and Polypeptide Sequences 
     One aspect of the present invention relates to novel plant cell cycle genes and polypeptides encoded by such genes. As used herein, the term “plant cell cycle genes” refers to genes encoding proteins that function during the plant cell cycle, and the term “plant cell cycle proteins” refers to proteins that function during the plant cell cycle. There are several known families of plant cell cycle proteins, including cyclin, cyclin dependent kinase, cyclin dependent kinase inhibitor, histone acetyltransferase, histone deacetylase, peptidyl-prolyl cis-trans isomerase, retinoblastoma-related protein, WEE1-like protein, and WD40 repeat protein. Although there is significant sequence homology within each gene and protein family, each member of each family can display different biochemical properties and altering the expression of at least one of these genes can result in a different plant phenotype. 
     The present invention provides novel plant cell cycle genes and polynucleotides and novel cell cycle proteins and polypeptides. In accordance with one embodiment of the invention, the novel plant cell cycle genes are the same as those expressed in a wild-type plant of a species of  Pinus  or  Eucalyptus.  Exemplary novel plant cell cycle gene sequences of the invention are set forth in Tables 9 and 10, which depict  Eucalyptus grandis  sequences and  Pinus radiata  sequences, respectively. Corresponding gene products, i.e., oligonucleotides and polypeptides, are also listed in Tables 14, 15, and 16. The Sequence Listing in APPENDIX 1 provides the sequences of these aspects of the invention. 
     The sequences of the invention have cell cycle activity and encode proteins that are active in the cell cycle, such as proteins of the cell cycle families discussed above. As discussed in more detail below, manipulation of the expression of the cell cycle genes and polynucleotides, or manipulation of the activity of the encoded proteins and polypeptides, can result in a transgenic plant with a desired phenotype that differs from the phenotype of a wild-type plant of the same species. 
     Throughout this description, reference is made to cell cycle gene products. As used herein, a “cell cycle gene product” is a product encoded by a cell cycle gene, and includes both nucleotide products, such as RNA, and amino acid products, such as proteins and polypeptides. Examples of specific cell cycle genes of the invention include SEQ ID NOs: 1-237. Examples of specific cell cycle gene products of the invention include products encoded by any one of SEQ ID NOs: 1-237. Reference also is made herein to cell cycle proteins and cell cycle polypeptides. Examples of specific cell cycle proteins and polypeptides of the invention include polypeptides encoded by any of SEQ ID NOs: 1-237 or polypeptides comprising the amino acid sequence of any of SEQ ID NOs: 261-497. One aspect of the invention is directed to a subset of these cell cycle genes and cell cycle gene products, namely SEQ ID NOs: 1-12, 14-58, 60-62, 64-70, 72-75, 77-83, 85-86, 88-91, 93-119, 121-130, 132-148, 150-156, 158-191, 193-207, 209-218, 220-221, 223-231, 233-237, their respective conservative variants (as that term is defined below), and the nucleotide and amino acid products encoded thereby. Another aspect of the invention is directed to a subset of the cell cycle genes and cell cycle gene products, namely SEQ ID NOs: 1-12, 14, 16-26, 30-37, 40-41, 43-76, 78-103, 106, 108-113, 116-121, 124-125, 128-147, 150-152, 154-155, 161-162, 164-172, 174, 177-183, 185-191, 193-197, 200-204, 208-213, and 215-234 their respective conservative variants, and the nucleotide and amino acid products encoded thereby. A further aspect of the invention is directed to a subset of the cell cycle genes and cell cycle gene products, namely SEQ ID NOs: 1-12, 14, 16-26, 30-37, 40-41, 43-58, 60-62, 64-70, 72-75, 78-83, 85-86, 88-91, 93-103, 106, 108-113, 116-119, 121, 124-125, 128-130, 132-147, 150-152, 154-155, 161-162, 164-172, 174, 177-183, 185-191, 193-197, 200-204, 209-213, 215-218, 220-221, 223-231, and 233-234 their respective conservative variants, and the nucleotide and amino acid products encoded thereby. 
     The present invention also includes sequences that are complements, reverse sequences, or reverse complements to the nucleotide sequences disclosed herein. 
     The present invention also includes conservative variants of the sequences disclosed herein. The term “variant,” as used herein, refers to a nucleotide or amino acid sequence that differs in one or more nucleotide bases or amino acid residues from the reference sequence of which it is a variant. 
     Thus, in one aspect, the invention includes conservative variant polynucleotides. As used herein, the term “conservative variant polynucleotide” refers to a polynucleotide that hybridizes under stringent conditions to an oligonucleotide probe that, under comparable conditions, binds to the reference gene the conservative variant is a variant of. Thus, for example, a conservative variant of SEQ ID NO: 1 hybridizes under stringent conditions to an oligonucleotide probe that, under comparable conditions, binds to SEQ ID NO: 1. One aspect of the invention provides conservative variant polynucleotides that exhibit at least about 75% sequence identity to their respective reference sequences. 
     “Sequence identity” has an art-recognized meaning and can be calculated using published techniques. See C OMPUTATIONAL  M OLECULAR  B IOLOGY,  Lesk, ed. (Oxford University Press, 1988), B IOCOMPUTING:  I NFORMATICS  A ND  G ENOME  P ROJECTS,  Smith, ed. (Academic Press, 1993), C OMPUTER  A NALYSIS  O F  S EQUENCE  D ATA,  P ART  I, Griffin &amp; Griffin, eds., (Humana Press, 1994), S EQUENCE  A NALYSIS  I N  M OLECULAR  B IOLOGY,  Von Heinje ed., Academic Press (1987), S EQUENCE  A NALYSIS  P RIMER,  Gribskov &amp; Devereux, eds. (Macmillan Stockton Press, 1991), and Carillo &amp; Lipton,  SIAM J. Applied Math.  48: 1073 (1988). Methods commonly employed to determine identity or similarity between two sequences include but are not limited to those disclosed in G UIDE  T O  H UGE  C OMPUTERS,  Bishop, ed., (Academic Press, 1994) and Carillo &amp; Lipton, supra. Methods to determine identity and similarity are codified in computer programs. Preferred computer program methods to determine identity and similarity between two sequences include but are not limited to the GCG program package (Devereux et al.,  Nucleic Acids Research  12: 387 (1984)), BLASTP, BLASTN, FASTA (Atschul et al.,  J. Mol. Biol.  215: 403 (1990)), and FASTDB (Brutlag et al.,  Comp. App. Biosci.  6: 237 (1990)). 
     The invention includes conservative variant polynucleotides having a sequence identity that is greater than or equal to 99%, 98%, 97%, 96%, 95%, 94%, 93%, 92%, 91%, 90%, 89%, 88%, 87%, 86%, 85%, 84%, 83%, 82%, 81%, 80%, 79%, 78%, 77%, 76%, 75%, 74%, 73%, 72%, 71%, 70%, 69%, 68%, 67%, 66%, 65%, 64%, 63%, 62%, 61%, or 60% to any one of SEQ ID NOs: 1 to 237. In such variants, differences between the variant and the reference sequence can occur at the 5′ or 3′ terminal positions of the reference nucleotide sequence or anywhere between those terminal positions, interspersed either individually among nucleotides in the reference sequence or in one or more contiguous groups within the reference sequence. 
     Additional conservative variant polynucleotides contemplated by and encompassed within the present invention include polynucleotides comprising sequences that differ from the polynucleotide sequences of SEQ ID NO: 1-237, or complements, reverse complements or reverse sequences thereof, as a result of deletions and/or insertions totaling less than 10% of the total sequence length. 
     The invention also includes conservative variant polynucleotides that, in addition to sharing a high degree of similarity in their primary structure (sequence) to SEQ ID NOs: 1 to 237, have at least one of the following features: (i) they contain an open reading frame or partial open reading frame encoding a polypeptide having substantially the same functional properties in the cell cycle as the polypeptide encoded by the reference polynucleotide, or (ii) they have nucleotide domains or encoded protein domains in common. The invention includes conservative variants of SEQ ID NOs: 1-237 that encode proteins having the enzyme or biological activity or binding properties of the protein encoded by the reference polynucleotide. Such conservative variants are functional variants, in that they have the enzymatic or binding activity of the protein encoded by the reference polynucleotide. 
     In accordance with the invention, polynucleotide variants can include a “shuffled gene” such as those described in e.g. U.S. Pat. Nos. 6,500,639, 6,500,617 6,436,675, 6,379,964, 6,352,859 6,335,198 6,326,204, and 6,287,862. A variant of a nucleotide sequence of the present invention also can be a polynucleotide modified as disclosed in U.S. Pat. No. 6,132,970, which is incorporated herein by reference. 
     In accordance with one embodiment, the invention provides a polynucleotide that encodes a cell cycle protein from one of the following families: cyclin, cyclin dependent kinase, cyclin dependent kinase inhibitor, histone acetyltransferase, histone deacetylase, peptidyl-prolyl cis-trans isomerase, retinoblastoma-related protein, WEE1-like protein, or WD40 repeat protein. SEQ ID NOs: 1-237 provide examples of such polynucleotides. 
     In accordance with another embodiment, a polynucelotide of the invention encodes the catalytic or protein binding domain of a polypeptide encoded by any of SEQ ID NOs: 1-237 or of a polypeptide comprising any of SEQ ID NOs: 261-497. The catalytic and protein binding domains of the cell cycle proteins of the invention are known in the art. The conserved sequences of these proteins are shown in Entries 1-195 as underlined, bold, and/or italicized text. 
     The invention also encompasses as conservative variants polynucleotides that differ from the sequences discussed above but that, as a consequence of the degeneracy of the genetic code, encode a polypeptide which is the same as that encoded by a polynucleotide of the present invention. The invention also includes as conservative variants polynucleotides comprising sequences that differ from the polynucleotide sequences discussed above as a result of substitutions that do not affect the amino acid sequence of the encoded polypeptide sequence, or that result in conservative substitutions in the encoded polypeptide sequence. 
     The present invention also includes an isolated polypeptide encoded by a polynucleotide comprising any of SEQ ID NOs: 1-237 or any of the conservative variants thereof discussed above. The invention also includes polypeptides comprising SEQ ID NOs: 261-497 and 495-497 and conservative variants of these polypeptides. Another aspect of the invention include polypeptides comprising SEQ ID NOs: 261-272, 274-318, 320-322, 324-330, 332-335, 337-343, 345-346, 348-351, 353-379, 381-390, 392-408, 410-416, 418-451, 453-467, 469-478, 480-481, 483-491, and 493-494 and conservative variants thereof. A further aspect of the invention includes polypeptides comprising SEQ ID NOs: 261-272, 274, 276-286, 289, 290-297, 300-301, 303-345, 347-363, 366, 368-373, 376-381, 384-385, 388-407, 410-412, 414-415, 420-422, 424-432, 434, 437-443, 445-451, 453-457, 460-464, 468-473, and 475-494 and conservative variants thereof. Another aspect of the invention includes polypeptides comprising SEQ ID NOs: 261-272, 274, 276-286, 290-297, 300-301, 303-318, 320-322, 324-330, 332-335, 337-343, 345, 348-351, 353-363, 366, 368-373, 376-381, 384-385, 388-390, 392-407, 410-412, 414-415, 421-422, 424-432, 434, 437-443, 445-451, 453-457, 460-464, 469-473, 475-478, 480-481, 483-491, and 493-494 and conservative variants thereof. 
     In accordance with the invention, a variant polypeptide or protein refers to an amino acid sequence that is altered by the addition, deletion or substitution of one or more amino acids. 
     The invention includes conservative variant polypeptides. As used herein, the term “conservative variant polypeptide” refers to a polypeptide that has similar structural, chemical or biological properties to the protein it is a conservative variant of. Guidance in determining which amino acid residues can be substituted, inserted, or deleted can be found using computer programs well known in the art such as Vector NTI Suite (InforMax, MD) software. In one embodiment of the invention, conservative variant polypeptides that exhibit at least about 75% sequence identity to their respective reference sequences. 
     Conservative variant protein includes an “isoform” or “analog” of the polypeptide. Polypeptide isoforms and analogs refers to proteins having the same physical and physiological properties and the same biological function, but whose amino acid sequences differs by one or more amino acids or whose sequence includes a non-natural amino acid. 
     Polypeptides comprising sequences that differ from the polypeptide sequences of SEQ ID NO: 261-497 as a result of amino acid substitutions, insertions, and/or deletions totaling less than 10% of the total sequence length are contemplated by and encompassed within the present invention. 
     One aspect of the invention provides conservative variant polypeptides that have the same function in the cell cycle as the proteins of which they are variants, as determined by one or more appropriate assays, such as those described below. The invention includes variant polypeptides that function as cell cycle proteins, such as those having the biological activity of cyclin, cyclin dependent kinase, cyclin dependent kinase inhibitor, histone acetyltransferase, histone deacetylase, peptidyl-prolyl cis-trans isomerase, retinoblastoma-related protein, WEE1-like protein, and WD40 repeat protein, and are thus capable of modulating the cell cycle in a plant. As discussed above, the invention includes variant polynucleotides that encode polypeptides that function as cell cycle proteins. 
     The activities and physical properties of cell cycle proteins can be examined using any method known in the art. The following examples of assay methods are not exhaustive and are included to provide some guidance in examining the activity and distinguishing protein characteristics of cell cycle protein variants. 
     CDK activity can be assessed using roscovitine as described in Yamaguchi et al.,  Proc. Natl. Acad. Sci. U.S.A.  100:8019 (2003). CDK histone kinase activity can be assayed using autoradiography to detect histone H1 phosphorylation by CDK as described in Joubés et al.,  Plant Physiol.  121:857 (1999). 
     CKI activity can be assayed using a variation of the method described in Zhou et al.,  Planta.  6:604 (2003). The modified method can employ co-transformation or subsequent transformations to identify the interaction of CKI and cyclins in vivo. For example, in the first transformation pine tissue can be transformed using the method described in U.S. Patent Application Publication No. 2002/0100083 using geneticin selection to obtain transgenic plants possessing cycD3 and cdc2a homologs. The second transformation can be performed using alpha-methyltryptophan as a selectable marker to obtain transformants having an ICK1 homologue as described in U.S. Provisional Application No. 60/476,189. Tissue capable of growing on both on geneticin and on alpha-methyltryptophan contains the ICK1 homologue and the cycD3 and cdc2a homologues. The CKI activity is determined by comparison of the phenotype of transformants having the cycD3 and cdc2a homologues to the transformants having ICK1 homologue and the cycD3 and cdc2a homologs. 
     Histone deacetylase activity can be assessed by complementation of the  Arabidopsis  mutants described in Tian et al.,  Genetics  165:399 (2003). Histone acetyltransferase activity can be assayed using anacardic acid as described in Balasubramanyam et al.,  J. Biol. Chem.  278:19134 (2003). Histone acetyltransferase also can be assayed using trichostatin A-treated plant lines as is described in Bhat et al.,  Plant J.  33:455 (2003). The plant lines described in Bhat et al., supra, also can be used to assay retinoblastoma-related proteins using the co-precipitation method described in Rossi et al.,  Plant Mol. Biol.  51:401 (2003). 
     Peptidyl-prolyl isomerase can be assayed as described in Edvardsson et al.,  FEBS Lett.  542:137 (2003). WD40 proteins can be evaluated based on the possession of the WD40 motif as well as their ability to interact with cdc2. WEE-1 can be assayed using any kinase activity assay known in the art. 
     2. Methods of Using Cell Cycle Genes, Polynucleotide and Polypeptide Sequences 
     The present invention provides methods of using plant cell cycle genes and conservative variants thereof. The invention includes methods and constructs for altering expression of plant cell cycle genes and/or gene products for purposes including, but not limited to (i) investigating function during the cell cycle and ultimate effect on plant phenotype and (ii) to effect a change in plant phenotype. For example, the invention includes methods and tools for modifying wood quality, fiber development, cell wall polysaccharide content, fruit ripening, and plant growth and yield by altering expression of one or more plant cell cycle genes. 
     The invention comprises methods of altering the expression of any of the cell cycle genes and variants discussed above. Thus, for example, the invention comprises altering expression of a cell cycle gene present in the genome of a wild-type plant of a species of  Eucalyptus  or  Pinus.  In one embodiment, the cell cycle gene comprises a nucleotide sequence selected from SEQ ID NOs: 1-237, from the subset thereof comprising SEQ ID NOs: SEQ ID NOs: 1-12, 14-58, 60-62, 64-70, 72-75, 77-83, 85-86, 88-91, 93-119, 121-130, 132-148, 150-156, 158-191, 193-207, 209-218, 220-221, 223-231, and 233-237, from the subset thereof comprising SEQ ID NOs: 1-12, 14, 16-26, 30-37, 40-41, 43-76, 78-103, 106, 108-113, 116-121, 124-125, 128-147, 150-152, 154-155, 161-162, 164-172, 174, 177-183, 185-191, 193-197, 200-204, 208-213, and 215-234, from the subset thereof comprising SEQ ID NOs: 1-12, 14, 16-26, 30-37, 40-41, 43-58, 60-62, 64-70, 72-75, 78-83, 85-86, 88-91, 93-103, 106, 108-113, 116-119, 121, 124-125, 128-130, 132-147, 150-152, 154-155, 161-162, 164-172, 174, 177-183, 185-191, 193-197, 200-204, 209-213, 215-218, 220-221, 223-231, and 233-234, or the conservative variants thereof, as discussed above. 
     Techniques which can be employed in accordance with the present invention to alter gene expression, include, but are not limited to: (i) over-expressing a gene product, (ii) disrupting a gene&#39;s transcript, such as disrupting a gene&#39;s mRNA transcript; (iii) disrupting the function of a polypeptide encoded by a gene, or (iv) disrupting the gene itself Over-expression of a gene product, the use of antisense RNAs, ribozymes, and the use of double-stranded RNA interference (dsRNAi) are valuable techniques for discovering the functional effects of a gene and for generating plants with a phenotype that is different from a wild-type plant of the same species. 
     Over-expression of a target gene often is accomplished by cloning the gene or cDNA into an expression vector and introducing the vector into recipient cells. Alternatively, over-expression can be accomplished by introducing exogenous promoters into cells to drive expression of genes residing in the genome. The effect of over-expression of a given gene on cell function, biochemical and/or physiological properties can then be evaluated by comparing plants transformed to over-express the gene to plants that have not been transformed to over-express the gene. 
     Antisense RNA, ribozyme, and dsRNAi technologies typically target RNA transcripts of genes, usually mRNA. Antisense RNA technology involves expressing in, or introducing into, a cell an RNA molecule (or RNA derivative) that is complementary to, or antisense to, sequences found in a particular mRNA in a cell. By associating with the mRNA, the antisense RNA can inhibit translation of the encoded gene product. The use of antisense technology to reduce or inhibit the expression of specific plant genes has been described, for example in European Patent Publication No. 271988, Smith et al.,  Nature,  334:724-726 (1988); Smith et. al.,  Plant Mol. Biol.,  14:369-379 (1990)). 
     A ribozyme is an RNA that has both a catalytic domain and a sequence that is complementary to a particular mRNA. The ribozyme functions by associating with the mRNA (through the complementary domain of the ribozyme) and then cleaving (degrading) the message using the catalytic domain. 
     RNA interference (RNAi) involves a post-transcriptional gene silencing (PTGS) regulatory process, in which the steady-state level of a specific mRNA is reduced by sequence-specific degradation of the transcribed, usually fully processed mRNA without an alteration in the rate of de novo transcription of the target gene itself. The RNAi technique is discussed, for example, in Elibashir, et al.,  Methods Enzymol.  26: 199 (2002); McManus &amp; Sharp,  Nature Rev. Genetics  3: 737 (2002); PCT application WO 01/75164; Martinez et al.,  Cell  110: 563 (2002); Elbashir et al., supra; Lagos-Quintana et al.,  Curr. Biol.  12: 735 (2002); Tuschl et al.,  Nat. Biotechnol.  20:446 (2002); Tuschl,  Chembiochem.  2: 239 (2001); Harborth et al.,  J. Cell Sci.  114: 4557 (2001); et al.,  EMBO J.  20:6877 (2001); Lagos-Quintana et al.,  Science.  294: 8538 (2001); Hutvagner et al.,  loc cit,  834; Elbashir et al.,  Nature.  411: 494 (2001). 
     The present invention provides a DNA construct comprising at least one polynucleotide of SEQ ID NOs: 1-235 or conservative variants thereof, such as the conservative variants discussed above. Any method known in the art can be used to generate the DNA constructs of the present invention. See, e.g. Sambrook et al., supra. 
     The invention includes DNA constructs that optionally comprise a promoter. Any suitable promoter known in the art can be used. A promoter is a nucleic acid, preferably DNA, that binds RNA polymerase and/or other transcription regulatory elements. As with any promoter, the promoters of the invention facilitate or control the transcription of DNA or RNA to generate an mRNA molecule from a nucleic acid molecule that is operably linked to the promoter. The RNA can encode a protein or polypeptide or can encode an antisense RNA molecule or a molecule useful in RNAi. Promoters useful in the invention include constitutive promoters, inducible promoters, temporally regulated promoters and tissue-preferred promoters. 
     Examples of useful constitutive plant promoters include: the cauliflower mosaic virus (CaMV) 35S promoter, which confers constitutive, high-level expression in most plant tissues (Odel et al.  Nature  313:810(1985)); the nopaline synthase promoter (An et al.  Plant Physiol.  88:547 (1988)); and the octopine synthase promoter (Fromm et al.,  Plant Cell  1: 977 (1989)). It should be noted that, although the CaMV 35S promoter is commonly referred to as a constitutive promoter, some tissue preference can be seen. The use of CaMV 35S is envisioned by the present invention, regardless of any tissue preference which may be exhibited during use in the present invention. 
     Inducible promoters regulate gene expression in response to environmental, hormonal, or chemical signals. Examples of hormone inducible promoters include auxin-inducible promoters (Baumann et al.  Plant Cell  11:323-334(1999)), cytokinin-inducible promoters (Guevara-Garcia,  Plant Mol. Biol.  38:743-753(1998)), and gibberellin-responsive promoters (Shi et al.  Plant Mol. Biol.  38:1053-1060(1998)). Additionally, promoters responsive to heat, light, wounding, pathogen resistance, and chemicals such as methyl jasmonate or salicylic acid, can be used in the DNA constructs and methods of the present invention. 
     Tissue-preferred promoters allow for preferred expression of polynucleotides of the invention in certain plant tissue. Tissue-preferred promoters are also useful for directing the expression of antisense RNA or siRNA in certain plant tissues, which can be useful for inhibiting or completely blocking the expression of targeted genes as discussed above. As used herein, vascular plant tissue refers to xylem, phloem or vascular cambium tissue. Other preferred tissue includes apical meristem, root, seed, and flower. In one aspect, the tissue-preferred promoters of the invention are either “xylem-preferred,” “cambium-preferred” or “phloem-preferred,” and preferentially direct expression of an operably linked nucleic acid sequence in the xylem, cambium or phloem, respectively. In another aspect, the DNA constructs of the invention comprise promoters that are tissue-specific for xylem, cambium or phloem, wherein the promoters are only active in the xylem, cambium or phloem. 
     A vascular-preferred promoter is preferentially active in any of the xylem, phloem or cambium tissues, or in at least two of the three tissue types. A vascular-specific promoter is specifically active in any of the xylem, phloem or cambium, or in at least two of the three. In other words, the promoters are only active in the xylem, cambium or phloem tissue of plants. Note, however, that because of solute transport in plants, a product that is specifically or preferentially expressed in a tissue may be found elsewhere in the plant after expression has occurred. 
     In another embodiment, the promoter is under temporal regulation, wherein the ability of the promoter to initiate expression is linked to factors such as the stage of the cell cycle or the stage of plant development. For example, the promoter of a cyclin D2 gene may be expressed only during the G1 and early S-phase, and the promoters of particular cyclin genes may be expressed only within the primary vascular poles of the developing seedling. 
     Additionally, the promoters of particular cell cycle genes may be expressed only within the cambium in developing secondary vasculature. Within the cambium, particular cell cycle gene promoters may be expressed exclusively in the stem or in the root. Moreover, the cell cycle promoters may be expressed only in the spring (for early wood formation) or only in the summer. 
     A promoter may be operably linked to the polynucleotide. As used in this context, operably linked refers to linking a polynucleotide encoding a structural gene to a promoter such that the promoter controls transcription of the structural gene. If the desired polynucleotide comprises a sequence encoding a protein product, the coding region can be operably linked to regulatory elements, such as to a promoter and a terminator, that bring about expression of an associated messenger RNA transcript and/or a protein product encoded by the desired polynucleotide. In this instance, the polynucleotide is operably linked in the 5′- to 3′-orientation to a promoter and, optionally, a terminator sequence. 
     Alternatively, the invention provides DNA constructs comprising a polynucleotide in an “antisense” orientation, the transcription of which produces nucleic acids that can form secondary structures that affect expression of an endogenous cell cycle gene in the plant cell. In another variation, the DNA construct may comprise a polynucleotide that yields a double-stranded RNA product upon transcription that initiates RNA interference of a cell cycle gene with which the polynucleotide is associated. A polynucleotide of the present invention can be positioned within a t-DNA, such that the left and right t-DNA border sequences flank or are on either side of the polynucleotide. 
     It should be understood that the invention includes DNA constructs comprising one or more of any of the polynucleotides discussed above. Thus, for example, a construct may comprise a t-DNA comprising one, two, three, four, five, six, seven, eight, nine, ten, or more polynucleotides. 
     The invention also includes DNA constructs comprising a promoter that includes one or more regulatory elements. Alternatively, the invention includes DNA constructs comprising a regulatory element that is separate from a promoter. Regulatory elements confer a number of important characteristics upon a promoter region. Some elements bind transcription factors that enhance the rate of transcription of the operably linked nucleic acid. Other elements bind repressors that inhibit transcription activity. The effect of transcription factors on promoter activity can determine whether the promoter activity is high or low, i.e. whether the promoter is “strong” or “weak.” 
     A DNA construct of the invention can include a nucleotide sequence that serves as a selectable marker useful in identifying and selecting transformed plant cells or plants. Examples of such markers include, but are not limited to, a neomycin phosphotransferase (nptII) gene (Potrykus et al.,  Mol. Gen. Genet.  199:183-188 (1985)), which confers kanamycin resistance. Cells expressing the nptII gene can be selected using an appropriate antibiotic such as kanamycin or G418. Other commonly used selectable markers include a mutant EPSP synthase gene (Hinchee et al.,  Bio/Technology  6:915-922 (1988)), which confers glyphosate resistance; and a mutant acetolactate synthase gene (ALS), which confers imidazolinone or sulphonylurea resistance (European Patent Application 154,204, 1985). 
     The present invention also includes vectors comprising the DNA constructs discussed above. The vectors can include an origin of replication (replicons) for a particular host cell. Various prokaryotic replicons are known to those skilled in the art, and function to direct autonomous replication and maintenance of a recombinant molecule in a prokaryotic host cell. 
     In one embodiment, the present invention utilizes a pWVR8 vector as described in U.S. Application No. 60/476,222, filed Jun. 6, 2003, or pART27 as described in Gleave,  Plant Mol. Biol,  20:1203-27 (1992). 
     The invention also provides host cells which are transformed with the DNA constructs of the invention. As used herein, a host cell refers to the cell in which a polynucleotide of the invention is expressed. Accordingly, a host cell can be an individual cell, a cell culture or cells that are part of an organism. The host cell can also be a portion of an embryo, endosperm, sperm or egg cell, or a fertilized egg. In one embodiment, the host cell is a plant cell. 
     The present invention further provides transgenic plants comprising the DNA constructs of the invention. The invention includes transgenic plants that are angiosperms or gymnosperms. The DNA constructs of the present invention can be used to transform a variety of plants, both monocotyledonous (e.g. grasses, corn, grains, oat, wheat and barley), dicotyledonous (e.g.,  Arabidopsis,  tobacco, legumes, alfalfa, oaks, eucalyptus, maple), and Gymnosperms (e.g., Scots pine; see Aronen,  Finnish Forest Res. Papers,  Vol. 595, 1996), white spruce (Ellis et al.,  Biotechnology  11:84-89, 1993), and larch (Huang et al.,  In Vitro Cell  27:201-207, 1991). 
     The plants also include turfgrass, wheat, maize, rice, sugar beet, potato, tomato, lettuce, carrot, strawberry, cassava, sweet potato, geranium, soybean, and various types of woody plants. Woody plants include trees such as palm oak, pine, maple, fir, apple, fig, plum and acacia. Woody plants also include rose and grape vines. 
     In one embodiment, the DNA constructs of the invention are used to transform woody plants, i.e., trees or shrubs whose stems live for a number of years and increase in diameter each year by the addition of woody tissue. The invention includes methods of transforming plants including eucalyptus and pine species of significance in the commercial forestry industry such as plants selected from the group consisting of  Eucalyptus grandis  and its hybrids, and  Pinus taeda,  as well as the transformed plants and wood and wood pulp derived therefrom. Other examples of suitable plants include those selected from the group consisting of  Pinus banksiana, Pinus brutia, Pinus caribaea, Pinus clausa, Pinus contorta, Pinus coulteri, Pinus echinata, Pinus eldarica, Pinus ellioti, Pinus jeffreyi, Pinus lambertiana, Pinus massoniana, Pinus monticola, Pinus nigra, Pinus palustris, Pinus pinaster, Pinus ponderosa, Pinus radiata, Pinus resinosa, Pinus rigida, Pinus serotina, Pinus strobus, Pinus sylvestris, Pinus taeda, Pinus virginiana, Abies amabilis, Abies balsamea, Abies concolor, Abies grandis, Abies lasiocarpa, Abies magnifica, Abies procera, Chamaecyparis lawsoniona, Chamaecyparis nootkatensis, Chamaecyparis thyoides, Juniperus virginiana, Larix decidua, Larix laricina, Larix leptolepis, Larix occidentalis, Larix siberica, Libocedrus decurrens, Picea abies, Picea engelmanni, Picea glauca, Picea mariana, Picea pungens, Picea rubens, Picea sitchensis, Pseudotsuga menziesii, Sequoia gigantea, Sequoia sempervirens, Taxodium distichum, Tsuga canadensis, Tsuga heterophylla, Tsuga mertensiana, Thuja occidentalis, Thuja plicata, Eucalyptus alba, Eucalyptus bancroftii, Eucalyptus botryoides, Eucalyptus bridgesiana, Eucalyptus calophylla, Eucalyptus camaldulensis, Eucalyptus citriodora, Eucalyptus cladocalyx, Eucalyptus coccifera, Eucalyptus curtisii, Eucalyptus dalrympleana, Eucalyptus deglupta, Eucalyptus delagatensis, Eucalyptus diversicolor, Eucalyptus dunnii, Eucalyptus ficifolia, Eucalyptus globulus, Eucalyptus gomphocephala, Eucalyptus gunnii, Eucalyptus henryi, Eucalyptus laevopinea, Eucalyptus macarthurii, Eucalyptus macrorhyncha, Eucalyptus maculata, Eucalyptus marginata, Eucalyptus megacarpa, Eucalyptus melliodora, Eucalyptus nicholii, Eucalyptus nitens, Eucalyptus nova - angelica, Eucalyptus obliqua, Eucalyptus occidentalis, Eucalyptus obtusiflora, Eucalyptus oreades, Eucalyptus pauciflora, Eucalyptus polybractea, Eucalyptus regnans, Eucalyptus resinifera, Eucalyptus robusta, Eucalyptus rudis, Eucalyptus saligna, Eucalyptus sideroxylon, Eucalyptus stuartiana, Eucalyptus tereticornis, Eucalyptus torelliana, Eucalyptus urnigera, Eucalyptus urophylla, Eucalyptus viminalis, Eucalyptus viridis, Eucalyptus wandoo,  and  Eucalyptus youmanni.    
     As used herein, the term “plant” also is intended to include the fruit, seeds, flower, strobilus, etc. of the plant. A transformed plant of the current invention can be a direct transfectant, meaning that the DNA construct was introduced directly into the plant, such as through  Agrobacterium,  or the plant can be the progeny of a transfected plant. The second or subsequent generation plant can be produced by sexual reproduction, i.e., fertilization. Furthermore, the plant can be a gametophyte (haploid stage) or a sporophyte (diploid stage). 
     As used herein, the term “plant tissue” encompasses any portion of a plant, including plant cells. Plant cells include suspension cultures, callus, embryos, meristematic regions, callus tissue, leaves, roots, shoots, gametophytes, sporophytes, pollen, seeds and microspores. Plant tissues can be grown in liquid or solid culture, or in soil or suitable media in pots, greenhouses or fields. As used herein, “plant tissue” also refers to a clone of a plant, seed, progeny, or propagule, whether generated sexually or asexually, and descendents of any of these, such as cuttings or seeds. 
     In accordance with one aspect of the invention, a transgenic plant that has been transformed with a DNA construct of the invention has a phenotype that is different from a plant that has not been transformed with the DNA construct. 
     As used herein, “phenotype” refers to a distinguishing feature or characteristic of a plant which can be altered according to the present invention by integrating one or more DNA constructs of the invention into the genome of at least one plant cell of a plant. The DNA construct can confer a change in the phenotype of a transformed plant by modifying any one or more of a number of genetic, molecular, biochemical, physiological, morphological, or agronomic characteristics or properties of the transformed plant cell or plant as a whole. 
     In one embodiment, transformation of a plant with a DNA construct of the present invention can yield a phenotype including, but not limited to any one or more of increased drought tolerance, herbicide resistance, reduced or increased height, reduced or increased branching, enhanced cold and frost tolerance, improved vigor, enhanced color, enhanced health and nutritional characteristics, improved storage, enhanced yield, enhanced salt tolerance, enhanced resistance of the wood to decay, enhanced resistance to fungal diseases, altered attractiveness to insect pests, enhanced heavy metal tolerance, increased disease tolerance, increased insect tolerance, increased water-stress tolerance, enhanced sweetness, improved texture, decreased phosphate content, increased germination, increased micronutrient uptake, improved starch composition, improved flower longevity, production of novel resins, and production of novel proteins or peptides. 
     In another embodiment, the affected phenotype includes one or more of the following traits: propensity to form reaction wood, a reduced period of juvenility, an increased period of juvenility, self-abscising branches, accelerated reproductive development or delayed reproductive development, as compared to a plant of the same species that has not been transformed with the DNA construct. 
     In a further embodiment, the phenotype that is different in the transgenic plant includes one or more of the following: lignin quality, lignin structure, wood composition, wood appearance, wood density, wood strength, wood stiffness, cellulose polymerization, fiber dimensions, lumen size, other plant components, plant cell division, plant cell development, number of cells per unit area, cell size, cell shape, cell wall composition, rate of wood formation, aesthetic appearance of wood, formation of stem defects, average microfibril angle, width of the S2 cell wall layer, rate of growth, rate of root formation ratio of root to branch vegetative development, leaf area index, and leaf shape. 
     Phenotype can be assessed by any suitable means. The plants can be evaluated based on their general morphology. Transgenic plants can be observed with the naked eye, can be weighed and their height measured. The plant can be examined by isolating individual layers of plant tissue, namely phloem and cambium, which is further sectioned into meristematic cells, early expansion, late expansion, secondary wall formation, and late cell maturation. See, e.g., Hertzberg, supra. The plants also can be assessed using microscopic analysis or chemical analysis. 
     Microscopic analysis includes examining cell types, stage of development, and stain uptake by tissues and cells. Fiber morphology, such as fiber wall thickness and microfibril angle of wood pulp fibers can be observed using, for example, microscopic transmission ellipsometry. See Ye and Sundström,  Tappi J.,  80:181 (1997). Wood strength, density, and grain slope in wet wood and standing trees can be determined by measuring the visible and near infrared spectral data in conjunction with multivariate analysis. See, U.S. Patent Application Publication Nos. 2002/0107644 and 2002/0113212. Lumen size can be measured using scanning electron microscopy. Lignin structure and chemical properties can be observed using nuclear magnetic resonance spectroscopy as described in Marita et al.,  J. Chem. Soc., Perkin Trans. I  2939 (2001). 
     The biochemical characteristic of lignin, cellulose, carbohydrates and other plant extracts can be evaluated by any standard analytical method known including spectrophotometry, fluorescence spectroscopy, HPLC, mass spectroscopy, and tissue staining methods. 
     As used herein, “transformation” refers to a process by which a nucleic acid is inserted into the genome of a plant cell. Such insertion encompasses stable introduction into the plant cell and transmission to progeny. Transformation also refers to transient insertion of a nucleic acid, wherein the resulting transformant transiently expresses the nucleic acid. Transformation can occur under natural or artificial conditions using various methods well known in the art. Transformation can be achieved by any known method for the insertion of nucleic acid sequences into a prokaryotic or eukaryotic host cell, including  Agrobacterium -mediated transformation protocols, viral infection, whiskers, electroporation, microinjection, polyethylene glycol-treatment, heat shock, lipofection, and particle bombardment. Transformation can also be accomplished using chloroplast transformation as described in e.g. Svab et al.,  Proc. Natl Acad. Sci.  87:8526-30 (1990). 
     In accordance with one embodiment of the invention, transformation in  Eucalyptus  is performed as described in U.S. Patent Application No. 60/476,222 (supra) which is incorporated herein by reference in its entirety. In accordance with another embodiment, transformation of  Pinus  is accomplished using the methods described in U.S. Patent Application Publication No. 2002/0100083. 
     Another aspect of the invention provides methods of obtaining wood and/or making wood pulp from a plant transformed with a DNA construct of the invention. Methods of producing a transgenic plant are provided above and are known in the art. A transformed plant can be cultured or grown under any suitable conditions. For example, pine can be cultured and grown as described in U.S. Patent Application Publication No. 2002/0100083.  Eucalyptus  can be cultured and grown as in, for example, Rydelius, et al., G ROWING  E UCALYPTUS FOR  P ULP AND  E NERGY,  presented at the Mechanization in Short Rotation, Intensive Culture Forestry Conference, Mobile, Ala., 1994. Wood and wood pulp can be obtained from the plant by any means known in the art. 
     As noted above, the wood or wood pulp obtained in accordance with this invention may demonstrate improved characteristics including, but not limited to any one or more of lignin composition, lignin structure, wood composition, cellulose polymerization, fiber dimensions, ratio of fibers to other plant components, plant cell division, plant cell development, number of cells per unit area, cell size, cell shape, cell wall composition, rate of wood formation, aesthetic appearance of wood, formation of stem defects, rate of growth, rate of root formation ratio of root to branch vegetative development, leaf area index, and leaf shape include increased or decreased lignin content, increased accessibility of lignin to chemical treatments, improved reactivity of lignin, increased or decreased cellulose content increased dimensional stability, increased tensile strength, increased shear strength, increased compression strength, increased shock resistance, increased stiffness, increased or decreased hardness, decreased spirality, decreased shrinkage, and differences in weight, density, and specific gravity. 
     B. Expression Profiling of Cell Cycle Genes 
     The present invention also provides methods and tools for performing expression profiling of cell cycle genes. Expression profiling is useful in determining whether genes are transcribed or translated, comparing transcript levels for particular genes in different tissues, genotyping, estimating DNA copy number, determining identity of descent, measuring mRNA decay rates, identifying protein binding sites, determining subcellular localization of gene products, correlating gene expression to a phenotype or other phenomenon, and determining the effect on other genes of the manipulation of a particular gene. Expression profiling is particularly useful for identifying gene expression in complex, multigenic events. For this reason, expression profiling is useful in correlating gene expression to plant phenotype and formation of plant tissues and the interconnection thereof to the cell cycle. 
     Only a small fraction of the genes of a plant&#39;s genome are expressed at a given time in a given tissue sample, and all of the expressed genes may not affect the plant phenotype. To identify genes capable of affecting a phenotype of interest, the present invention provides methods and tools for determining, for example, a gene expression profile at a given point in the cell cycle, a gene expression profile at a given point in plant development, and a gene expression profile a given tissue sample. The invention also provides methods and tools for identifying cell cycle genes whose expression can be manipulated to alter plant phenotype or to alter the biological activity of cell cycle gene products. In support of these methods, the invention also provides methods and tools that distinguish expression of different genes of the same family. 
     As used herein, “gene expression” refers to the process of transcription of a DNA sequence into an RNA sequence, followed by translation of the RNA into a protein, which may or may not undergo post-translational processing. Thus, the relationship between cell cycle stage and/or developmental stage and gene expression can be observed by detecting, quantitatively or qualitatively, changes in the level of an RNA or a protein. As used herein, the term “biological activity” includes, but is not limited to, the activity of a protein gene product, including enzyme activity. 
     The present invention provides oligonucleotides that are useful in these expression profiling methods. Each oligonucleotide is capable of hybridizing under a given set of conditions to a cell cycle gene or gene product. In one aspect of the invention, a plurality of oligonucleotides is provided, wherein each oligonucleotide hybridizes under a given set of conditions to a different cell cycle gene product. Examples of oligonucleotides of the present invention include SEQ ID NOs: 471-697. Each of the oligos of SEQ ID NOs 471-697 hybridizes under standard conditions to a different gene product of one of SEQ ID NOs: 1-237. The oligonucleotides of the invention are useful in determining the expression of one or more cell cycle genes in any of the above-described methods. 
     1. Cell, Tissue, Nucleic Acid, and Protein Samples 
     Samples for use in methods of the present invention may be derived from plant tissue. Suitable plant tissues include, but are not limited to, somatic embryos, pollen, leaves, stems, calli, stolons, microtubers, shoots, xylem, male strolbili, pollen cones, vascular tissue, apical meristem, vascular cambium, xylem, root, flower, and seed. 
     According to the present invention “plant tissue” is used as described previously herein. Plant tissue can be obtained from any of the plants types or species described supra. 
     In accordance with one aspect of the invention, samples are obtained from plant tissue at different stages of the cell cycle, from plant tissue at different developmental stages, from plant tissue at various times of the year (e.g. spring versus summer), from plant tissues subject to different environmental conditions (e.g. variations in light and temperature) and/or from different types of plant tissue and cells. In accordance with one embodiment, plant tissue is obtained during various stages of maturity and during different seasons of the year. For example, plant tissue can be collected from stem dividing cells, differentiating xylem, early developing wood cells, differentiated spring wood cells, and differentiated summer wood cells. As another example, gene expression in a sample obtained from a plant with developing wood can be compared to gene expression in a sample obtained from a plant which does not have developing wood. 
     Differentiating xylem includes samples obtained from compression wood, side-wood, and normal vertical xylem. Methods of obtaining samples for expression profiling from pine and eucalyptus are known. See, e.g., Allona et al.,  Proc. Nat&#39;l Acad. Sci.  95:9693-8 (1998) and Whetton et al.,  Plant Mol. Biol.  47:275-91, and Kirst et al., I NT&#39;L  U NION OF  F ORESTRY  R ESEARCH  O RGANIZATIONS  B IENNIAL  C ONFERENCE,  S6.8 (June 2003, Umea, Sweden). 
     In one embodiment of the invention, gene expression in one type of tissue is compared to gene expression in a different type of tissue or to gene expression in the same type of tissue in a difference stage of development. Gene expression can also be compared in one type of tissue which is sampled at various times during the year (different seasons). For example, gene expression in juvenile secondary xylem can be compared to gene expression in mature secondary xylem. Similarly, gene expression in cambium can be compared to gene expression in xylem. Furthermore, gene expression in apical meristems can be compared to gene expression in cambium. 
     In an alternative embodiment, differences in gene expression are determined as cells from different tissues advance during the cell cycle. In this method, the cells from the different tissues are synchronized and their gene expression is profiled. Methods of synchronizing the stage of cell cycle in a sample are known. These methods include, e.g., cold acclimation, photoperiod, and aphidicoline. See, e.g., Nagata et al.,  Int. Rev. Cytol.  132:1-30 (1992), Breyne and Zabeau,  Curr. Opin. Plant Biol.  4:136-42, 140 (2001). A sample is obtained during a specific stage of the cell cycle and gene expression in that sample is compared to a sample obtained during a different stage of the cell cycle. For example, tissue can be examined in any of the phases of the cell cycle, such as mitosis, G1, G0, S, and G2. In particular, one can examine the changes in gene expression at the G1, G2, and metaphase checkpoints. 
     In another embodiment of the invention, a sample is obtained from a plant having a specific phenotype and gene expression in that sample is compared to a sample obtained from a plant of the same species that does not have that phenotype. For example, a sample can be obtained from a plant exhibiting a fast rate of growth and gene expression can be compared with that of a sample obtained from a plant exhibiting a normal or slow rate of growth. Differentially expressed genes identified from such a comparison can be correlated with growth rate and, therefore, useful for manipulating growth rate. 
     In a further embodiment, a sample is obtained from clonally propagated plants. In one embodiment the clonally propagated plants are of the species  Pinus  or  Eucalyptus.  Individual ramets from the same genotype can be sacrificed at different times of year. Thus, for any genotype there can be at least two genetically identical trees sacrificed, early in the season and late in the season. Each of these trees can be divided into juvenile (top) to mature (bottom) samples. Further, tissue samples can be divided into, for example, phloem to xylem, in at least 5 layers of peeling. Each of these samples can be evaluated for phenotype and gene expression. See Entry 196. 
     Where cellular components may interfere with an analytical technique, such as a hybridization assay, enzyme assay, a ligand binding assay, or a biological activity assay, it may be desirable to isolate the gene products from such cellular components. Gene products, including nucleic acid and amino acid gene products, can be isolated from cell fragments or lysates by any method known in the art. 
     Nucleic acids used in accordance with the invention can be prepared by any available method or process, or by other processes as they become known in the art. Conventional techniques for isolating nucleic acids are detailed, for example, in Tijssen, L ABORATORY  T ECHNIQUES IN  B IOCHEMISTRY AND  M OLECULAR  B IOLOGY:  H YBRIDIZATION  W ITH  N UCLEIC  A CID  P ROBES,  chapter 3 (Elsevier Press, 1993), Berger and Kimmel,  Methods Enzymol.  152:1 (1987), and G IBCO  BRL &amp; L IFE  T ECHNOLOGIES  T RIZOL  RNA I SOLATION  P ROTOCOL,  Form No. 3786 (2000). Techniques for preparing nucleic acid samples, and sequencing polynucleotides from pine and eucalyptus are known. See, e.g., Allona et al., supra and Whetton et al., supra, and U.S. Application No. 60/476,222. 
     A suitable nucleic acid sample can contain any type of nucleic acid derived from the transcript of a cell cycle gene, i.e., RNA or a subsequence thereof or a nucleic acid for which an mRNA transcribed from a cell cycle gene served as a template. Suitable nucleic acids include cDNA reverse-transcribed from a transcript, RNA transcribed from that cDNA, DNA amplified from the cDNA, and RNA transcribed from the amplified DNA. Detection of such products or derived products is indicative of the presence and/or abundance of the transcript in the sample. Thus, suitable samples include, but are not limited to, transcripts of the gene or genes, cDNA reverse-transcribed from the transcript, cRNA transcribed from the cDNA, DNA amplified from the genes, and RNA transcribed from amplified DNA. As used herein, the category of “transcripts” includes but is not limited to pre-mRNA nascent transcripts, transcript processing intermediates, and mature mRNAs and degradation products thereof. 
     It is not necessary to monitor all types of transcripts to practice the invention. For example, the expression profiling methods of the invention can be conducted by detecting only one type of transcript, such as mature mRNA levels only. 
     In one aspect of the invention, a chromosomal DNA or cDNA library (comprising, for example, fluorescently labeled cDNA synthesized from total cell mRNA) is prepared for use in hybridization methods according to recognized methods in the art. See Sambrook et al., supra. 
     In another aspect of the invention, mRNA is amplified using, e.g., the MessageAmp kit (Ambion). In a further aspect, the mRNA is labeled with a detectable label. For example, mRNA can be labeled with a fluorescent chromophore, such as CyDye (Amersham Biosciences). 
     In some applications, it may be desirable to inhibit or destroy RNase that often is present in homogenates or lysates, before use in hybridization techniques. Methods of inhibiting or destroying nucleases are well known. In one embodiment of the invention, cells or tissues are homogenized in the presence of chaotropic agents to inhibit nuclease. In another embodiment, RNase is inhibited or destroyed by heat treatment, followed by proteinase treatment. 
     Protein samples can be obtained by any means known in the art. Protein samples useful in the methods of the invention include crude cell lysates and crude tissue homogenates. Alternatively, protein samples can be purified. Various methods of protein purification well known in the art can be found in Marshak et al., S TRATEGIES FOR  P ROTEIN  P URIFICATION AND  C HARACTERIZATION:  A L ABORATORY  C OURSE  M ANUAL  (Cold Spring Harbor Laboratory Press 1996). 
     2. Detecting Level of Gene Expression 
     For methods of the invention that comprise detecting a level of gene expression, any method for observing gene expression can be used, without limitation. Such methods include traditional nucleic acid hybridization techniques, polymerase chain reaction (PCR) based methods, and protein determination. The invention includes detection methods that use solid support-based assay formats as well as those that use solution-based assay formats. 
     Absolute measurements of the expression levels need not be made, although they can be made. The invention includes methods comprising comparisons of differences in expression levels between samples. Comparison of expression levels can be done visually or manually, or can be automated and done by a machine, using for example optical detection means. Subrahmanyam et al.,  Blood.  97: 2457 (2001); Prashar et al.,  Methods Enzymol.  303: 258 (1999). Hardware and software for analyzing differential expression of genes are available, and can be used in practicing the present invention. See, e.g., GenStat Software and GeneExpress® GX Explorer™ Training Manual, supra; Baxevanis &amp; Francis-Ouellette, supra. 
     In accordance with one embodiment of the invention, nucleic acid hybridization techniques are used to observe gene expression. Exemplary hybridization techniques include Northern blotting, Southern blotting, solution hybridization, and S1 nuclease protection assays. 
     Nucleic acid hybridization typically involves contacting an oligonucleotide probe and a sample comprising nucleic acids under conditions where the probe can form stable hybrid duplexes with its complementary nucleic acid through complementary base pairing. For example, see PCT application WO 99/32660; Berger &amp; Kimmel,  Methods Enzymol.  152: 1 (1987). The nucleic acids that do not form hybrid duplexes are then washed away leaving the hybridized nucleic acids to be detected, typically through detection of an attached detectable label. The detectable label can be present on the probe, or on the nucleic acid sample. In one embodiment, the nucleic acids of the sample are detectably labeled polynucleotides representing the mRNA transcripts present in a plant tissue (e.g., a cDNA library). Detectable labels are commonly radioactive or fluorescent labels, but any label capable of detection can be used. Labels can be incorporated by several approached described, for instance, in WO 99/32660, supra. In one aspect RNA can be amplified using the MessageAmp kit (Ambion) with the addition of aminoallyl-UTP as well as free UTP. The aminoallyl groups incorporated into the amplified RNA can be reacted with a fluorescent chromophore, such as CyDye (Amersham Biosciences) 
     Duplexes of nucleic acids are destabilized by increasing the temperature or decreasing the salt concentration of the buffer containing the nucleic acids. Under low stringency conditions (e.g., low temperature and/or high salt) hybrid duplexes (e.g., DNA:DNA, RNA:RNA or RNA:DNA) will form even where the annealed sequences are not perfectly complementary. Thus, specificity of hybridization is reduced at lower stringency. Conversely, at higher stringency (e.g., higher temperature and/or lower salt and/or in the presence of destabilizing reagents) hybridization tolerates fewer mismatches. 
     Typically, stringent conditions for short probes (e.g., 10 to 50 nucleotide bases) will be those in which the salt concentration is at least about 0.01 to 1.0 M at pH 7.0 to 8.3 and the temperature is at least about 30° C. Stringent conditions can also be achieved with the addition of destabilizing agents such as formamide. 
     Under some circumstances, it can be desirable to perform hybridization at conditions of low stringency, e.g., 6×SSPE-T (0.9 M NaCl, 60 mM NaH 2 PO 4 , pH 7.6, 6 mM EDTA, 0.005% Triton) at 37° C., to ensure hybridization. Subsequent washes can then be performed at higher stringency (e.g., 1×SSPE-T at 37° C.) to eliminate mismatched hybrid duplexes. Successive washes can be performed at increasingly higher stringency (e.g., down to as low as 0.25×SSPE-T at 37° C. to 50° C.) until a desired level of hybridization specificity is obtained. 
     In general, standard conditions for hybridization is a compromise between stringency (hybridization specificity) and signal intensity. Thus, in one embodiment of the invention, the hybridized nucleic acids are washed at successively higher stringency conditions and read between each wash. Analysis of the data sets produced in this manner will reveal a wash stringency above which the hybridization pattern is not appreciably altered and which provides adequate signal for the particular oligonucleotide probes of interest. For example, the final wash may be selected as that of the highest stringency that produces consistent results and that provides a signal intensity greater than approximately 10% of the background intensity. 
     a. Oligonucleotide Probes 
     Oligonucleotide probes useful in nucleic acid hybridization techniques employed in the present invention are capable of binding to a nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing via hydrogen bond formation. A probe can include natural bases (i.e., A, G, U, C or T) or modified bases (7-deazaguanosine, inosine, etc.). In addition, the nucleotide bases in the probes can be joined by a linkage other than a phosphodiester bond, so long as it does not interfere with hybridization. Thus, probes can be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages. 
     Oligonucleotide probes can be prepared by any means known in the art. Probes useful in the present invention are capable of hybridizing to a nucleotide product of cell cycle genes, such as one of SEQ ID NOs: 1-237. Probes useful in the invention can be generated using the nucleotide sequences disclosed in SEQ ID NOs: 1-237. The invention includes oligonucleotide probes having at least a 2, 10,15, 20, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, or 100 nucleotide fragment of a corresponding contiguous sequence of any one of SEQ ID NOs: 1-237. The invention includes oligonucleotides of less than 2, 1, 0.5, 0.1, or 0.05 kb in length. In one embodiment, the oligonucleotide is 60 nucleotides in length. 
     Oligonucleotide probes can be designed by any means known in the art. See, e.g., Li and Stormo, Bioinformatics 17: 1067-76 (2001). Oligonucleotide probe design can be effected using software. Exemplary software includes ArrayDesigner, GeneScan, and ProbeSelect. Probes complementary to a defined nucleic acid sequence can be synthesized chemically, generated from longer nucleotides using restriction enzymes, or can be obtained using techniques such as polymerase chain reaction (PCR). PCR methods are well known and are described, for example, in Innis et al. eds., PCR P ROTOCOLS:  A G UIDE TO  M ETHODS AND  A PPLICATIONS,  Academic Press Inc. San Diego, Calif. (1990). The probes can be labeled, for example, with a radioactive, biotinylated, or fluorescent tag. Optimally, the nucleic acids in the sample are labeled and the probes are not labeled. Oligonucleotide probes generated by the above methods can be used in solution or solid support-based methods. 
     The invention includes oligonucleotide probes that hybridize to a product of the coding region or a 3′ untranslated region (3′ UTR) of a cell cycle gene. In one embodiment, the oligonucleotide probe hybridizes to the 3′UTR of any one of SEQ ID NOs: 1-237. The 3′ UTR is generally a unique region of the gene, even among members of the same family. Therefore, the probes capable of hybridizing to a product of the 3′ UTR can be useful for differentiating the expression of individual genes within a family where the coding region of the genes likely are highly homologous. This allows for the design of oligonucleotide probes to be used as members of a plurality of oligonucleotides, each capable of uniquely binding to a single gene. In another embodiment, the oligonucleotide probe comprises any one of SEQ ID NOs: 471-697. In another embodiment, the oligonucleotide probe consists of any one of SEQ ID NOs:471-697. 
     b. Oligonucleotide Array Methods 
     One embodiment of the invention employs two or more oligonucleotide probes in combination to detect a level of expression of one or more cell cycle genes, such as the genes of SEQ ID NOs: 1-237. In one aspect of this embodiment, the level of expression of two or more different genes is detected. The two or more genes may be from the same or different cell cycle gene families discussed above. Each of the two or more oligonucleotides may hybridize to a different one of the genes. 
     One embodiment of the invention employs two or more oligonucleotide probes, each of which specifically hybridize to a polynucleotide derived from the transcript of a gene provided by SEQ ID NOs: 1-237. Another embodiment employs two or more oligonucleotide probes, at least one of which comprises a nucleic acid sequence of SEQ ID NOs: 471-697. Another embodiment employs two or more oligonucleotide probes, at least one of which consists of SEQ ID NOs: 471-697. 
     The oligonucleotide probes may comprise from about 5 to about 60, or from about 5 to about 500, nucleotide bases, such as from about 60 to about 100 nucleotide bases, including from about 15 to about 60 nucleotide bases. 
     One embodiment of the invention uses solid support-based oligonucleotide hybridization methods to detect gene expression. Solid support-based methods suitable for practicing the present invention are widely known and are described, for example, in PCT application WO 95/11755; Huber et al.,  Anal. Biochem.  299: 24 (2001); Meiyanto et al.,  Biotechniques.  31: 406 (2001); Relogio et al.,  Nucleic Acids Res.  30:e51 (2002). Any solid surface to which oligonucleotides can be bound, covalently or non-covalently, can be used. Such solid supports include filters, polyvinyl chloride dishes, silicon or glass based chips, etc. 
     One embodiment uses oligonucleotide arrays, i.e. microarrays, which can be used to simultaneously observe the expression of a number of genes or gene products. Oligonucleotide arrays comprise two or more oligonucleotide probes provided on a solid support, wherein each probe occupies a unique location on the support. The location of each probe may be predetermined, such that detection of a detectable signal at a given location is indicative of hybridization to an oligonucleotide probe of a known identity. Each predetermined location can contain more than one molecule of a probe, but each molecule within the predetermined location has an identical sequence. Such predetermined locations are termed features. There can be, for example, from 2, 10, 100, 1,000, 2,000 or 5,000 or more of such features on a single solid support. In one embodiment, each oligonucleotide is located at a unique position on an array at least 2, at least 3, at least 4, at least 5, at least 6, or at least 10 times. 
     Oligonucleotide probe arrays for detecting gene expression can be made and used according to conventional techniques described, for example, in Lockhart et al.,  Nat&#39;l Biotech.  14: 1675 (1996), McGall et al.,  Proc. Nat&#39;l Acad. Sci. USA  93: 13555 (1996), and Hughes et al.,  Nature Biotechnol.  19:342 (2001). A variety of oligonucleotide array designs is suitable for the practice of this invention. 
     In one embodiment the one or more oligonucleotides include a plurality of oligonucleotides that each hybridize to a different gene expressed in a particular tissue type. For example, the tissue can be developing wood. 
     In one embodiment, a nucleic acid sample obtained from a plant can be amplified and, optionally labeled with a detectable label. Any method of nucleic acid amplification and any detectable label suitable for such purpose can be used. For example, amplification reactions can be performed using, e.g. Ambion&#39;s MessageAmp, which creates “antisense” RNA or “aRNA” (complementary in nucleic acid sequence to the RNA extracted from the sample tissue). The RNA can optionally be labeled using CyDye fluorescent labels. During the amplification step, aaUTP is incorporated into the resulting aRNA. The CyDye fluorescent labels are coupled to the aaUTPs in a non-enzymatic reaction. Subsequent to the amplification and labeling steps, labeled amplified antisense RNAs are precipitated and washed with appropriate buffer, and then assayed for purity. For example, purity can be assay using a NanoDrop spectrophotometer. The nucleic acid sample is then contacted with an oligonucleotide array having, attached to a solid substrate (a “microarray slide”), oligonucleotide sample probes capable of hybridizing to nucleic acids of interest which may be present in the sample. The step of contacting is performed under conditions where hybridization can occur between the nucleic acids of interest and the oligonucleotide probes present on the array. The array is then washed to remove non-specifically bound nucleic acids and the signals from the labeled molecules that remain hybridized to oligonucleotide probes on the solid substrate are detected. The step of detection can be accomplished using any method appropriate to the type of label used. For example, the step of detecting can accomplished using a laser scanner and detector. For example, on can use and Axon scanner which optionally uses GenePix Pro software to analyze the position of the signal on the microarray slide. 
     Data from one or more microarray slides can analyzed by any appropriate method known in the art. 
     Oligonucleotide probes used in the methods of the present invention, including microarray techniques, can be generated using PCR. PCR primers used in generating the probes are chosen, for example, based on the sequences of SEQ ID NOs:1-237, to result in amplification of unique fragments of the cell cycle genes (i.e., fragments that hybridize to only one polynucleotide of any one of SEQ ID NOs: 1-237 under standard hybridization conditions). Computer programs are useful in the design of primers with the required specificity and optimal hybridization properties. For example, Li and Stormo, supra at 1075, discuss a method of probe selection using ProbeSelect which selects an optimum oligonucleotide probe based on the entire gene sequence as well as other gene sequences to be probed at the same time. 
     In one embodiment, oligonucleotide control probes also are used. Exemplary control probes can fall into at least one of three categories referred to herein as (1) normalization controls, (2) expression level controls and (3) negative controls. In microarray methods, one or more of these control probes may be provided on the array with the inventive cell cycle gene-related oligonucleotides. 
     Normalization controls correct for dye biases, tissue biases, dust, slide irregularities, malformed slide spots, etc. Normalization controls are oligonucleotide or other nucleic acid probes that are complementary to labeled reference oligonucleotides or other nucleic acid sequences that are added to the nucleic acid sample to be screened. The signals obtained from the normalization controls, after hybridization, provide a control for variations in hybridization conditions, label intensity, reading efficiency and other factors that can cause the signal of a perfect hybridization to vary between arrays. In one embodiment, signals (e.g., fluorescence intensity or radioactivity) read from all other probes used in the method are divided by the signal from the control probes, thereby normalizing the measurements. 
     Virtually any probe can serve as a normalization control. Hybridization efficiency varies, however, with base composition and probe length. Preferred normalization probes are selected to reflect the average length of the other probes being used, but they also can be selected to cover a range of lengths. Further, the normalization control(s) can be selected to reflect the average base composition of the other probes being used. In one embodiment, only one or a few normalization probes are used, and they are selected such that they hybridize well (i.e., without forming secondary structures) and do not match any test probes. In one embodiment, the normalization controls are mammalian genes. 
     Expression level controls probes hybridize specifically with constitutively expressed genes present in the biological sample. Virtually any constitutively expressed gene provides a suitable target for expression level control probes. Typically, expression level control probes have sequences complementary to subsequences of constitutively expressed “housekeeping genes” including, but not limited to certain photosynthesis genes. 
     “Negative control” probes are not complementary to any of the test oligonucleotides (i.e., the inventive cell cycle gene-related oligonucleotides), normalization controls, or expression controls. In one embodiment, the negative control is a mammalian gene which is not complementary to any other sequence in the sample. 
     The terms “background” and “background signal intensity” refer to hybridization signals resulting from non-specific binding or other interactions between the labeled target nucleic acids (i.e., mRNA present in the biological sample) and components of the oligonucleotide array. Background signals also can be produced by intrinsic fluorescence of the array components themselves. 
     A single background signal can be calculated for the entire array, or a different background signal can be calculated for each target nucleic acid. In a one embodiment, background is calculated as the average hybridization signal intensity for the lowest 5 to 10 percent of the oligonucleotide probes being used, or, where a different background signal is calculated for each target gene, for the lowest 5 to 10 percent of the probes for each gene. Where the oligonucleotide probes corresponding to a particular cell cycle gene hybridize well and, hence, appear to bind specifically to a target sequence, they should not be used in a background signal calculation. Alternatively, background can be calculated as the average hybridization signal intensity produced by hybridization to probes that are not complementary to any sequence found in the sample (e.g., probes directed to nucleic acids of the opposite sense or to genes not found in the sample). In microarray methods, background can be calculated as the average signal intensity produced by regions of the array that lack any oligonucleotides probes at all. 
     c. PCR-Based Methods 
     In another embodiment, PCR-based methods are used to detect gene expression. These methods include reverse-transcriptase-mediated polymerase chain reaction (RT-PCR) including real-time and endpoint quantitative reverse-transcriptase-mediated polymerase chain reaction (Q-RTPCR). These methods are well known in the art. For example, methods of quantitative PCR can be carried out using kits and methods that are commercially available from, for example, Applied BioSystems and Stratagene®. See also Kochanowski, Q UANTITATIVE  PCR P ROTOCOLS  (Humana Press, 1999); Innis et al., supra.; Vandesompele et al.,  Genome Biol.  3: RESEARCH0034 (2002); Stein,  Cell Mol. Life Sci.  59: 1235 (2002). 
     Gene expression can also be observed in solution using Q-RTPCR. Q-RTPCR relies on detection of a fluorescent signal produced proportionally during amplification of a PCR product. See Innis et al., supra. Like the traditional PCR method, this technique employs PCR oligonucleotide primers, typically 15-30 bases long, that hybridize to opposite strands and regions flanking the DNA region of interest. Additionally, a probe (e.g., TaqMan®, Applied Biosystems) is designed to hybridize to the target sequence between the forward and reverse primers traditionally used in the PCR technique. The probe is labeled at the 5′ end with a reporter fluorophore, such as 6-carboxyfluorescein (6-FAM) and a quencher fluorophore like 6-carboxy-tetramethyl-rhodamine (TAMRA). As long as the probe is intact, fluorescent energy transfer occurs which results in the absorbance of the fluorescence emission of the reporter fluorophore by the quenching fluorophore. As Taq polymerase extends the primer, however, the intrinsic 5′ to 3′ nuclease activity of Taq degrades the probe, releasing the reporter fluorophore. The increase in the fluorescence signal detected during the amplification cycle is proportional to the amount of product generated in each cycle. 
     The forward and reverse amplification primers and internal hybridization probe is designed to hybridize specifically and uniquely with one nucleotide derived from the transcript of a target gene. In one embodiment, the selection criteria for primer and probe sequences incorporates constraints regarding nucleotide content and size to accommodate TaqMan® requirements. 
     SYBR Green® can be used as a probe-less Q-RTPCR alternative to the Taqman®-type assay, discussed above. ABI P RISM®  7900 S EQUENCE  D ETECTION  S YSTEM  U SER  G UIDE  A PPLIED  B IOSYSTEMS,  chap. 1-8, App. A-F. (2002). 
     A device measures changes in fluorescence emission intensity during PCR amplification. The measurement is done in “real time,” that is, as the amplification product accumulates in the reaction. Other methods can be used to measure changes in fluorescence resulting from probe digestion. For example, fluorescence polarization can distinguish between large and small molecules based on molecular tumbling (see U.S. Pat. No. 5,593,867). 
     d. Protein Detection Methods 
     Proteins can be observed by any means known in the art, including immunological methods, enzyme assays and protein array/proteomics techniques. 
     Measurement of the translational state can be performed according to several protein methods. For example, whole genome monitoring of protein—the “proteome”—can be carried out by constructing a microarray in which binding sites comprise immobilized, preferably monoclonal, antibodies specific to a plurality of proteins having an amino acid sequence of any of SEQ ID NOs: 261-497 or proteins encoded by the genes of SEQ ID NOs:1-237 or conservative variants thereof. See Wildt et al.,  Nature Biotechnol.  18: 989 (2000). Methods for making polyclonal and monoclonal antibodies are well known, as described, for instance, in Harlow &amp; Lane, A NTIBODIES:  A L ABORATORY  M ANUAL  (Cold Spring Harbor Laboratory Press, 1988). 
     Alternatively, proteins can be separated by two-dimensional gel electrophoresis systems. Two-dimensional gel electrophoresis is well-known in the art and typically involves isoelectric focusing along a first dimension followed by SDS-PAGE electrophoresis along a second dimension. See, e.g., Hames et al, G EL  E LECTROPHORESIS OF  P ROTEINS:  A P RACTICAL  A PPROACH  (IRL Press, 1990). The resulting electropherograms can be analyzed by numerous techniques, including mass spectrometric techniques, western blotting and immunoblot analysis using polyclonal and monoclonal antibodies, and internal and N-terminal micro-sequencing. 
     3. Correlating Gene Expression to Phenotype and Tissue Development 
     As discussed above, the invention provides methods and tools to correlate gene expression to plant phenotype. Gene expression may be examined in a plant having a phenotype of interest and compared to a plant that does not have the phenotype or has a different phenotype. Such a phenotype includes, but is not limited to, increased drought tolerance, herbicide resistance, reduced or increased height, reduced or increased branching, enhanced cold and frost tolerance, improved vigor, enhanced color, enhanced health and nutritional characteristics, improved storage, enhanced yield, enhanced salt tolerance, enhanced resistance of the wood to decay, enhanced resistance to fungal diseases, altered attractiveness to insect pests, enhanced heavy metal tolerance, increased disease tolerance, increased insect tolerance, increased water-stress tolerance, enhanced sweetness, improved texture, decreased phosphate content, increased germination, increased micronutrient uptake, improved starch composition, improved flower longevity, production of novel resins, and production of novel proteins or peptides. 
     In another embodiment, the phenotype includes one or more of the following traits: propensity to form reaction wood, a reduced period of juvenility, an increased period of juvenility, self-abscising branches, accelerated reproductive development or delayed reproductive development. 
     In a further embodiment, the phenotype that is differs in the plants compares includes one or more of the following: lignin quality, lignin structure, wood composition, wood appearance, wood density, wood strength, wood stiffness, cellulose polymerization, fiber dimensions, lumen size, other plant components, plant cell division, plant cell development, number of cells per unit area, cell size, cell shape, cell wall composition, rate of wood formation, aesthetic appearance of wood, formation of stem defects, average microfibril angle, width of the S2 cell wall layer, rate of growth, rate of root formation ratio of root to branch vegetative development, leaf area index, and leaf shape. 
     Phenotype can be assessed by any suitable means as discussed above. 
     In a further embodiment, gene expression can be correlated to a given point in the cell cycle, a given point in plant development, and in a given tissue sample. Plant tissue can be examined at different stages of the cell cycle, from plant tissue at different developmental stages, from plant tissue at various times of the year (e.g. spring versus summer), from plant tissues subject to different environmental conditions (e.g. variations in light and temperature) and/or from different types of plant tissue and cells. In accordance with one embodiment, plant tissue is obtained during various stages of maturity and during different seasons of the year. For example, plant tissue can be collected from stem dividing cells, differentiating xylem, early developing wood cells, differentiated spring wood cells, differentiated summer wood cells. 
     It will be apparent to those skilled in the art that various modifications and variations can be made in the methods and compositions of the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention cover the modifications and variations of this invention provided they come within the scope of the appended claims and their equivalents. 
     The following examples are given to illustrate the present invention. It should be understood, however, that the invention is not to be limited to the specific conditions or details described in these examples. Throughout the specification, any and all references to a publicly available document, including a U.S. patent, are specifically incorporated by reference. 
     Examples 
     Example 1 
     Example 1 illustrates a procedure for RNA extraction and purification, which is particularly useful for RNA obtained from conifer needle, xylem, cambium, and phloem. 
     Tissue is obtained from conifer needle, xylem, cambium or phloem. The tissue is frozen in liquid nitrogen and ground. The total RNA is extracted using Concert Plant RNA reagent (Invitrogen). The resulting RNA sample is extracted into phenol:chloroform and treated with DNase. The RNA is then incubated at 65° C. for 2 minutes followed by centrifugation at 4° C. for 30 minutes. Following centrifugation, the RNA is extracted into phenol at least 10 times to remove contaminants. 
     The RNA is further cleaned using RNeasy columns (Qiagen). The purified RNA is quantified using RiboGreen reagent (Molecular Probes) and purity assessed by gel electrophoresis. 
     RNA is then amplified using MessageAmp (Ambion). Aminoallyl-UTP and free UTP are added to the in vitro transcription of the purified RNA at a ratio of 4:1 aminoallyl-UTP-to-UTP. The aminoallyl-UTP is incorporated into the new RNA strand as it is transcribed. The amino-allyl group is then reacted with Cy dyes to attach the colorimetric label to the resulting amplified RNA using the Amersham procedure modified for use with RNA. Unincorporated dye is removed by ethanol precipitation. The labeled RNA is quantified spectrophotometrically (NanoDrop). The labeled RNA is fragmented by heating to 95° C. as described in Hughes et al.,  Nature Biotechnol.  19:342 (2001). 
     Example 2 
     Example 2 illustrates how cell cycle genes important for wood development in  Pinus radiata  can be determined and how oligonucleotides which uniquely bind to those genes can be designed and synthesized for use on a microarray. 
     Pine trees of the species  Pinus radiata  are grown under natural light conditions. Tissue samples are prepared as described in, e.g., Sterky et al.,  Proc. Nat&#39;l Acad. Sci.  95:13330 (1998). Specifically, tissue samples are collected from woody trees having a height of 5 meters. Tissue samples of the woody trees are prepared by taking tangential sections through the cambial region of the stem. The stems are sectioned horizontally into sections ranging from juvenile (top) to mature (bottom). The stem sections separated by stage of development are further separated into 5 layers by peeling into sections of phloem, differentiating phloem, cambium, differentiating xylem, developing xylem, and mature xylem. Tissue samples, including leaves, buds, shoots, and roots are also prepared from seedlings of the species  Pinus radiata.    
     RNA is isolated and ESTs generated as described in Example 1 or Sterky et al., supra. The nucleic acid sequences of ESTs derived from samples containing developing wood are compared with nucleic acid sequences of genes known to be involved in the plant cell cycle. ESTs from samples that do not contain developing wood are also compared with sequences of genes known to be involved in the plant cell cycle. An in silico hybridization analysis is performed using BLAST (NCBI). Sequences from among the known cell cycle genes that show hybridization in silico to ESTs made from samples containing developing wood, but that do not hybridize to ESTs from samples not containing developing wood are selected for further examination. 
     cDNA clones containing sequences that hybridize to the genes showing wood-preferred expression are selected from cDNA libraries using techniques well known in the art of molecular biology. Using the sequence information, oligonucleotides are designed such that each oligonucleotide is specific for only one cDNA sequence in the library. The oligonucleotide sequences are provided in Table 14. 60-mer oligonucleotide probes are designed using the method of Li and Stormo, supra or using software such as ArrayDesigner, GeneScan, and ProbeSelect. 
     The oligonucleotides are then synthesized in situ described in Hughes et al.,  Nature Biotechnol.  19:324 (2002) or as described in Kane et al.,  Nucleic Acids Res.  28:4552 (2000) and affixed to an activated glass slide (Sigma-Genosis, The Woodlands, Tex.) using a 5′ amino linker. The position of each oligonucleotide on the slide is known. 
     Example 3 
     Example 3 illustrates how cell cycle genes important for wood development in  Eucalyptus grandis  can be determined and how oligonucleotides which uniquely bind to those genes can be designed and synthesized for use on a microarray. 
     Eucalyptus trees of the species  Eucalyptus grandis  are grown under natural light conditions. Tissue samples are prepared as described in, e.g., Sterky et al.,  Proc. Nat&#39;l Acad. Sci.  95:13330 (1998). Specifically, tissue samples are collected from woody trees having a height of 5 meters. Tissue samples of the woody trees are prepared by taking tangential sections through the cambial region of the stem. The stems are sectioned horizontally into sections ranging from juvenile (top) to mature (bottom). The stem sections separated by stage of development are further separated into 5 layers by peeling into sections of phloem, differentiating phloem, cambium, differentiating xylem, developing xylem, and mature xylem. Tissue samples, including leaves, buds, shoots, and roots are also prepared from seedlings of the species  Pinus radiata.    
     RNA is isolated and ESTs generated as described in Example 1 or Sterky et al., supra. The nucleic acid sequences of ESTs derived from samples containing developing wood are compared with nucleic acid sequences of genes known to be involved in the plant cell cycle. ESTs from samples that do not contain developing wood are also compared with sequences of genes known to be involved in the plant cell cycle. An in silico hybridization analysis is performed as described in, for example, Audic and Claverie,  Genome Res.  7:986 (1997). Sequences from among the known cell cycle genes that show hybridization in silico to ESTs made from samples containing developing wood, but do not hybridize to ESTs from samples not containing developing wood are selected for further examination. 
     cDNA clones containing sequences that hybridize to the genes showing wood-preferred expression are selected from cDNA libraries using techniques well known in the art of molecular biology. Using the sequence information, oligonucleotides are designed such that each oligonucleotide is specific for only one cDNA sequence in the library. The oligonucleotide sequences are provided in Table 14. 60-mer oligonucleotide probes are designed using the method of Li and Stormo, supra or using software such as ArrayDesigner, GeneScan, and ProbeSelect. 
     The oligonucleotides are then synthesized in situ described in Hughes et al.,  Nature Biotechnol.  19:324 (2002) or as described in Kane et al.,  Nucleic Acids Res.  28:4552 (2000) and affixed to an activated glass slide (Sigma-Genosus, The Woodlands, Tex.) using a 5′ amino linker. The position of each oligonucleotide on the slide is known. 
     Example 4 
     Example 4 illustrates how to detect expression of  Pinus radiata  cell cycle genes which are important in wood formation using an oligonucleotide microarray prepared as in Example 2. This is an example of a balanced incomplete block designed experiment carried out using aRNA samples prepared from mature-phase phloem (P), cambium (C), expanding xylem found in a layer below the cambium (X1) and differentiating, lignifying xylem cells found deeper in the same growth ring (X2). In this example, cell cycle gene expression is compared among the four samples, namely P, C, X1, and X2. 
     In the summer, plants of the species  Pinus radiata  are felled and the bark of the main stem is immediately pulled gently away to reveal the phloem and xylem. The phloem and xylem are then peeled with a scalpel into separate containers of liquid nitrogen. Needles (leaves) and buds from the trees are also harvested with a scalpel into separate containers of liquid nitrogen. RNA is subsequently isolated from the frozen tissue samples as described in Example 1. Equal microgram quantities of total RNA are purified from each sample using RNeasy Mini columns (Qiagen, Valencia, Calif.) according to the manufacturers instructions. 
     Amplification reactions are carried out for each of the P, C, X1, and X2 tissue samples. Amplification reactions are performed using Ambion&#39;s MessageAmp kit, a T7-based amplification procedure, following the manufacturer&#39;s instructions, except that labeled aaUTP is added to the reagent mix during in the amplification step. aaUTP is incorporated into the resulting antisense RNA formed during this step. CyDye fluorescent labels are coupled to the aaUTPs in a non-enzymatic reaction as described in Example 1. Labeled amplified antisense RNAs are precipitated and washed, and then assayed for purity using a NanoDrop spectrophotometer. These labeled antisense RNAs, corresponding to the RNA isolated from the P, C, X1, and X2 tissue samples, constitute the sample nucleic acids, which are referred to as the P, C, X1, and X2 samples. 
     Normalization control samples of known nucleic acids are added to each sample in a dilution series of 500, 200, 100, 50, 25 and 10 pg/μl for quantitation of the signals. Positive controls corresponding to specific genes showing expression in all tissues of pine, such as housekeeping genes, are also added to the plant sample. 
     Each of four microarray slides is incubated with 125 μL of a P, C, X1 or X2 sample under a coverslip at 42° C. for 16-18 hours. The arrays are washed in 1×SSC, 0.1% SDS for 10 minutes and then in 0.1×SSC, 0.1% SDS for 10 minutes and the allowed to dry. 
     The array slides are scanned using an Axon laser scanner and analyzed using GenePix Pro software. Data from the microarray slides are subjected to microarray data analysis using GenStat SAS or Spotfire software. Outliers are removed and ratiometric data for each of the datasets are normalized using a global normalization which employs a cubic spline fit applied to correct for differential dye bias and spatial effects. A second transformation is performed to fit control signal ratios to a mean log 2 =0 (i.e. 1:1 ratio). Normalized data are then subjected to a variance analysis. 
     Mean signal intensity for each signal at any given position on the microarray slide is determined for each of three of P, C, X1, and X2 sample microarray slides. This mean signal/probe position is compared to the signal at the same position on sample slide which was not used for calculating the mean. For example, a mean signal at a given position is determined for P, C, and X1 and the signal at that position in the X2 microarray slide is compared to the P, C, and X1 mean signal value. 
     Table 1 shows genes having greater than doubled signal with any one sample as compared to the mean signal of the other three samples. 
     
       
         
           
               
               
               
               
               
             
               
                   
                 TABLE 1 
               
               
                   
                   
               
               
                   
                 Gene 
                 PvCX12 
                 PvX12 
                 CvX12 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 WD40 repeat protein A 
                 −1.24 
                 −0.88 
                 −1.07 
               
               
                   
                 CDC2 
                 −1.09 
                 −0.78 
                 −0.92 
               
               
                   
                 CYCLIN 
                 −1.08 
                 −1 
                 −0.26 
               
               
                   
                 WD-40 repeat protein B 
                 −1.01 
                 −0.87 
                 −0.42 
               
               
                   
                 CDC2 
                 −0.83 
                 −0.49 
                 −1.01 
               
               
                   
                   
               
               
                   
                 P = Phloem 
               
               
                   
                 C = Cambium 
               
               
                   
                 X1 = xylem layer-1 
               
               
                   
                 X2 = xylem layer-2 
               
               
                   
                 PvCX12 = Ratio of the signal for Phloem target versus mean signal for Cambium, Xylem1, and Xylem2 targets 
               
            
           
         
       
     
     The data shows that WD40 repeat protein A encodes a WD40 repeat protein is less highly expressed in cambium than in developing xylem, while WD40 repeat protein B encodes a WD40 repeat protein that is more highly expressed in phloem than in the other tissues. 
     Signal data are then verified with RT-PCR to confirm gene expression in the target tissue of the genes corresponding to the unique oligonucleotides in the probe. 
     Example 5 
     Example 5 demonstrates how one can correlate cell cycle gene expression with agronomically important wood phenotypes such as density, stiffness, strength, distance between branches, and spiral grain. 
     Mature clonally propagated pine trees are selected from among the progeny of known parent trees for superior growth characteristics and resistance to important fungal diseases. The bark is removed from a tangential section and the trees are examined for average wood density in the fifth annual ring at breast height, stiffness and strength of the wood, and spiral grain. The trees are also characterized by their height, mean distance between major branches, crown size, and forking. 
     To obtain seedling families that are segregating for major genes that affect density, stiffness, strength, distance between branches, spiral grain and other characteristics that may be linked to any of the genes affecting these characteristics, trees lacking common parents are chosen for specific crosses on the criterion that they exhibit the widest variation from each other with respect to the density, stiffness, strength, distance between branches, and spiral grain criteria. Thus, pollen from a plus tree exhibiting high density, low mean distance between major branches, and high spiral grain is used to pollinate cones from the unrelated plus tree among the selections exhibiting the lowest density, highest mean distance between major branches, and lowest spiral grain. It is useful to note that “plus trees” are crossed such that pollen from a plus tree exhibiting high density are used to pollinate developing cones from another plus tree exhibiting high density, for example, and pollen from a tree exhibiting low mean distance between major branches would be used to pollinate developing cones from another plus tree exhibiting low mean distance between major branches. 
     Seeds are collected from these controlled pollinations and grown such that the parental identity is maintained for each seed and used for vegetative propagation such that each genotype is represented by multiple ramets. Vegetative propagation is accomplished using micropropagation, hedging, or fascicle cuttings. Some ramets of each genotype are stored while vegetative propagules of each genotype are grown to sufficient size for establishment of a field planting. The genotypes are arrayed in a replicated design and grown under field conditions where the daily temperature and rainfall are measured and recorded. 
     The trees are measured at various ages to determine the expression and segregation of density, stiffness, strength, distance between branches, spiral grain, and any other observable characteristics that may be linked to any of the genes affecting these characteristics. Samples are harvested for characterization of cellulose content, lignin content, cellulose microfibril angle, density, strength, stiffness, tracheid morphology, ring width, and the like. Samples are also examined for gene expression as described in Example 4. Ramets of each genotype are compared to ramets of the same genotype at different ages to establish age:age correlations for these characteristics. 
     Example 6 
     Example 6 demonstrates how the stage of plant development and responses to environmental conditions such as light and season can be correlated to cell cycle gene expression using microarrays prepared as in Example 4. In particular, the changes in gene expression associated with wood density are examined. 
     Trees of three different clonally propagated  Eucalyptus grandis  hybrid genotypes are grown on a site with a weather station that measures daily temperatures and rainfall. During the spring and subsequent summer, genetically identical ramets of the three different genotypes are first photographed with north-south orientation marks, using photography at sufficient resolution to show bark characteristics of juvenile and mature portions of the plant, and then felled as in Example 4. The age of the trees is determined by planting records and confirmed by a count of the annual rings. In each of these trees, mature wood is defined as the outermost rings of the tree below breast height, and juvenile wood as the innermost rings of the tree above breast height. Each tree is accordingly sectored as follows: 
     NM—NORTHSIDE MATURE 
     SM—SOUTHSIDE MATURE 
     NT—NORTHSIDE TRANSITION 
     ST—SOUTHSIDE TRANSITION 
     NJ—NORTHSIDE JUVENILE 
     SJ—SOUTHSIDE JUVENILE 
     Tissue is harvested from the plant trunk as well as from juvenile and mature form leaves. Samples are prepared simultaneously for phenotype analysis, including plant morphology and biochemical characteristics, and gene expression analysis. The height and diameter of the tree at the point from which each sector was taken is recorded, and a soil sample from the base of the tree is taken for chemical assay. Samples prepared for gene expression analysis are weighed and placed into liquid nitrogen for subsequent preparation of RNA samples for use in the microarray experiment. The tissues are denoted as follows: 
     P—phloem 
     C—cambium 
     X1—expanding xylem 
     X2—differentiating and lignifying xylem 
     Thin slices in tangential and radial sections from each of the sectors of the trunk are fixed as described in Ruzin, Plant Microtechnique and Microscopy, Oxford University Press, Inc., New York, N.Y. (1999) for anatomical examination and confirmation of wood developmental stage. Microfibril angle is examined at the different developmental stages of the wood, for example juvenile, transition and mature phases of  Eucalyptus grandis  wood. Other characteristics examined are the ratio of fibers to vessel elements and ray tissue in each sector. Additionally, the samples are examined for characteristics that change between juvenile and mature wood and between spring wood and summer wood, such as fiber morphology, lumen size, and width of the S2 (thickest) cell wall layer. Samples are further examined for measurements of density in the fifth ring and determination of modulus of elasticity using techniques well known to those skilled in the art of wood assays. See, e.g., Wang, et al.,  Non - destructive Evaluations of Trees,  E XPERIMENTAL  T ECHNIQUES,  pp. 28-30 (2000). 
     For biochemical analysis, 50 grams from each of the harvest samples are freeze-dried and analyzed, using biochemical assays well known to those skilled in the art of plant biochemistry for quantities of simple sugars, amino acids, lipids, other extractives, lignin, and cellulose. See, e.g., Pettersen &amp; Schwandt,  J. Wood Chem.  &amp;  Technol.  11:495 (1991). 
     In the present example, the phenotypes chosen for comparison are high density wood, average density wood, and low density wood. Nucleic acid samples are prepared as described in Example 3, from trees harvested in the spring and summer. Gene expression profiling by hybridization and data analysis is performed as described in Examples 3 and 4. 
     Using similar techniques and clonally propagated individuals one can examine cell cycle gene expression as it is related to other complex wood characteristics such as strength, stiffness and spirality. 
     Example 7 
     Example 7 demonstrates the ability of the oligonucleotide probes of the invention to distinguish between highly homologous members of a family of cell cycle genes. Hybridization to a particular oligonucleotide on the array identifies a unique WD40 gene that is expressed more strongly in a genotype having a higher density wood than in observed in other genotypes examined. The WD40 gene is also expressed more strongly in mature wood than in juvenile wood and more strongly in summer wood than in spring wood. This gene is not found to be expressed at high levels either in leaves or buds. 
     The gene expression pattern is confirmed by RT-PCR. This gene, the putative “density-related” gene, is used for in situ hybridization of fixed radial sections. The density-related WD40 gene hybridizes most strongly to the vascular cambium in regions of the stem where the xylem is comprised primarily of fibers with few vessel elements and few xylem ray cells. 
     These results suggest that the WD40 gene product functions in radial cell division, which occurs in the cambium and results in diameter growth, rather than in axial cell division such as may be important in the apex or leaves. Such a gene would be difficult to identify by cDNA microarrays or other traditional hybridization means because the highly conserved regions present in the gene would result in confusing it with genes encoding enzymes having similar catalytic functions, but acting in axial or radial divisions. Furthermore, from the sequence similarity-based annotation suggesting a function of this gene product in cell division and the observation of this microarray hybridization pattern, confirmed by RT-PCR and in silico hybridization, this gene product functions specifically in developing secondary xylem to guide the cell division patterns of fibers, such that higher expression of this gene results in greater fiber production relative to vessel element or ray production. The fiber content is correlated with a principal components analysis (PCA) variable that accounts for at least 10% of the variation in basic density. 
     Example 8 
     Example 8 demonstrates how the use of oligonucleotide probes of the invention can be used to identify one wood “density related” WD40 repeat protein gene and its promoter from among the family of homologous genes. Further, this example demonstrates how a promoter sequence identified using this method is used to transform other hardwood species to result in increased diameter growth rates as compared to wild-type plants of the same species. 
     The sequence of the WD40 gene is used to probe a Genome Walker library in order to isolate 5′ flanking sequences comprising a promoter region. The promoter region is then operably linked to a beta-glucuronidase reporter gene and cloned into a binary vector for transformation into  Eucalyptus  using the method described in U.S. Application Ser. No. 60/476,222. Regenerated transgenic tobacco and  Eucalyptus  plants are then sectioned and stained using X-gluc, demonstrating that the microarray data results in isolation of a promoter capable of highly cambial-specific expression solely in those portions of the stem that develop more fibers than vessel elements or xylem rays. 
     Using techniques well known to those skilled in the art of molecular biology, the promoter is then operably linked to a cell division promoting gene and this construct placed in a binary vector for transformation into hardwood plants such as Sweetgum and Populus, such that the cell division promoting gene is expressed more strongly than normally in the vascular cambium. This results in increased diameter growth rate in the transgenic hardwood plants relative to control hardwood plants. 
     Example 9 
     Example 9 demonstrates how a density related polypeptide can be linked to a tissue-preferred promoter and expressed in pine resulting in a plant with increased wood density. 
     A density-related polypeptide, which is more highly expressed during the early spring, is identified by the method described in Example 7. A DNA construct having the density-related polypeptide operably linked to a promoter is placed into an appropriate binary vector and transformed into pine using the method of Connett et al. (U.S. patent application Ser. Nos. 09/973,088 and 09/973,089). Pine plants are transformed as described in Connett et al., supra, and the transgenic pine plants are used to establish a forest planting. Increased density even in the spring wood (early wood) is observed in the transgenic pine plants relative to control pine plants which are not transformed with the density related DNA construct. 
     Example 10 
     Using techniques well known to those skilled in the art of molecular biology, the sequence of the putative density-related gene isolated in Example 7 is analyzed in genomic DNA isolated from alfalfa. This enables the identification of an orthologue in alfalfa whose sequence is then used to create an RNAi knockout construct. This construct is then transformed into alfalfa. See, e.g., Austin et al.,  Euphytica  85, 381 1995. The regenerated transgenic plants show lower fiber content and increased ray cells content in the xylem. Such properties improved digestability which results in higher growth rates in cattle fed on this alfalfa as compared to wild-type alfalfa of the same species. 
     Example 11 
     Example 11 demonstrates how gene expression analysis can be used to find gene variants which are present in mature plants having a desirable phenotype. The presence or absence of such a variant can be used to predict the phenotype of a mature plant, allowing screening of the plants at the seedling stage. Although this example employs eucalyptus, the method used herein is also useful in breeding programs for pine and other tree species. 
     The sequence of a putative density-related gene is used to probe genomic DNA isolated from  Eucalyptus  that vary in density as described in previous examples. Non-transgenically produced  Eucalyptus  hybrids of different wood phenotypes are examined. One hybrid exhibits high wood density and another hybrid exhibits lower wood density. A molecular marker in the 3′ portion of the coding region is found which distinguishes a high-density gene variant from a lower density gene variant. 
     This molecular marker enables tree breeders to assay non-transgenic  Eucalyptus  hybrids for likely density profiles while the trees are still at seedling stage, whereas in the absence of the marker, tree breeders must wait until the trees have grown for multiple years before density at harvest age can be reliably predicted. This enables selective outplanting of the best trees at seedling stage rather than an expensive culling operation and resultant erosion at thinning age. This molecular marker is further useful in the breeding program to determine which parents will give rise to high density outcross progeny. 
     Molecular markers found in the 3′ portion of the coding region of the gene that do not correspond to variants seen more frequently in higher or lower wood density non-transgenic  Eucalyptus  hybrid trees are also useful. These markers are found to be useful for fingerprinting different genotypes of  Eucalyptus,  for use in identity-tracking in the breeding program and in plantations. 
     Example 12 
     This Example describes microarrays for identifying gene expression differences that contribute to the phenotypic characteristics that are important in commercial wood, namely wood appearance, stiffness, strength, density, fiber dimensions, coarseness, cellulose and lignin content, extractives content and the like. 
     As in Examples 2-4, woody trees of genera that produce commercially important wood products, in this case  Pinus  and  Eucalyptus,  are felled from various sites and at various times of year for the collection and isolation of RNA from developing xylem, cambium, phloem, leaves, buds, roots, and other tissues. RNA is also isolated from seedlings of the same genera. 
     All contigs are compared to both the ESTs made from RNA isolated from samples containing developing wood and the sequences of the ESTs made from RNA of various tissues that do not contain developing wood. Contigs containing primarily ESTs that show more hybridization in silico to ESTs made from RNA isolated from samples containing developing wood than to ESTs made from RNA isolated from samples not containing developing wood are determined to correspond to possible novel genes particularly expressed in developing wood. These contigs are then used for BLAST searches against public domain sequences. Those contigs that hybridize with high stringency to no known genes or genes annotated as having only a “hypothetical protein” are selected for the next step. These contigs are considered putative novel genes showing wood-preferred expression. 
     The longest cDNA clones containing sequences hybridizing to the putative novel genes showing wood-preferred expression are selected from cDNA libraries using techniques well known to those skilled in the art of molecular biology. The cDNAs are sequenced and full-length gene-coding sequences together with untranslated flanking sequences are obtained where possible. Stretches of 45-80 nucleotides (or oligonucleotides) are selected from each of the sequences of putative novel genes showing wood-preferred expression such that each oligonucleotide probe hybridizes at high stringency to only one sequence represented in the ESTs made from RNA isolated from trees or seedlings of the same genus. 
     Oligomers are then chemically synthesized and placed onto a microarray slide as described in Example 3. Each oligomer corresponds to a particular sequence of a putative novel gene showing wood-preferred expression and to no other gene whose sequence is represented among the ESTs made from RNA isolated from trees or seedlings of the same genus. 
     Sample preparation and hybridization are carried out as in Example 4. The technique used in this example is more effective than use of a microarray using cDNA probes because the presence of a signal represents significant evidence of the expression of a particular gene, rather than of any of a number of genes that may contain similarities to the cDNA due to conserved functional domains or common evolutionary history. Thus, it is possible to differentiate homologous genes, such as those in the same family, but which may have different functions in phenotype determination. 
     Thus hybridization data, gained using the method of Example 4, enable the user to identify which of the putative novel genes actually has a pattern of coordinate expression with known genes, a pattern of expression consistent with a particular developmental role, and/or a pattern of expression that suggests that the gene has a promoter that drives expression in a valuable way. 
     The hybridization data thus using this method can be used, for example, to identify a putative novel gene that shows an expression pattern particular to the tracheids with the lowest cellulose microfibril angle in developing spring wood (early wood). The promoter of this gene can also be isolated as in Example 8, and operably linked to a gene that has been shown as in Example 9 to be associated with late wood (summer wood). Transgenic pine plants containing this construct are generated using the methods of Example 9, and the early wood of these plants is then shown to display several characteristics of late wood, such as higher microfibril angle, higher density, smaller average lumen size, etc. 
     Example 13 
     Example 13 demonstrates the use of a cambium-specific promoter functionally linked to a cell cycle gene for increased plant biomass. 
     Cambium-specific cell cycle transcripts are identified via array analyses of different secondary vasculature layers as described in Example 4. Candidate promoters linked to the genes corresponding to these transcripts are cloned from pine genomic DNA using, e.g., the BD Clontech GenomeWalker kit and tested in transgenic tobacco via a reporter assay(s) for cambium specificity/preference. The cambium-specific promoter overexpressing a cell cycle gene involved in secondary xylem cell division is used to increased wood biomass. A tandem cambium-specific promoter is constructed driving the cell cycle ORF. Boosted transcript levels of the candidate cell cycle gene result in an increased xylem biomass phenotype. 
     Example 14 
     Isolation and Characterization of cDNA Clones from  Eucalyptus Grandis    
       Eucalyptus grandis  cDNA expression libraries were prepared from mature shoot buds, early wood phloem, floral tissue, leaf tissue (two independent libraries), feeder roots, structural roots, xylem or early wood xylem and were constructed and screened as follows. 
     Total RNA was extracted from the plant tissue using the protocol of Chang et al. ( Plant Molecular Biology Reporter  11:113-116 (1993). mRNA was isolated from the total RNA preparation using either a Poly(A) Quik mRNA Isolation Kit (Stratagene, La Jolla, Calif.) or Dynal Beads Oligo (dT) 25  (Dynal, Skogen, Norway). A cDNA expression library was constructed from the purified mRNA by reverse transcriptase synthesis followed by insertion of the resulting cDNA clones in Lambda ZAP using a ZAP Express cDNA Synthesis Kit (Stratagene), according to the manufacturer&#39;s protocol. The resulting cDNAs were packaged using a Gigapack II Packaging Extract (Stratagene) using an aliquot (1-5 αl) from the 5 μl ligation reaction dependent upon the library. Mass excision of the library was done using XL1-Blue MRF′ cells and XLOLR cells (Stratagene) with ExAssist helper phage (Stratagene). The excised phagemids were diluted with NZY broth (Gibco BRL, Gaithersburg, Md.) and plated out onto LB-kanamycin agar plates containing X-gal and isopropylthio-beta-galactoside (IPTG). 
     Of the colonies plated and selected for DNA miniprep, 99% contained an insert suitable for sequencing. Positive colonies were cultured in NZY broth with kanamycin and cDNA was purified by means of alkaline lysis and polyethylene glycol (PEG) precipitation. Agarose gel at 1% was used to screen sequencing templates for chromosomal contamination. Dye primer sequences were prepared using a Turbo Catalyst 800 machine (Perkin Elmer/Applied Biosystems Division, Foster City, Calif.) according to the manufacturer&#39;s protocol. 
     DNA sequence for positive clones was obtained using a Perkin Elmer/Applied Biosystems Division Prism 377 sequencer. cDNA clones were sequenced first from the 5′ end and, in some cases, also from the 3′ end. For some clones, internal sequence was obtained using either Exonuclease III deletion analysis, yielding a library of differentially sized subclones in pBK-CMV, or by direct sequencing using gene-specific primers designed to identified regions of the gene of interest. 
     The determined cDNA sequences were compared with known sequences in the EMBL database using the computer algorithms FASTA and/or BLASTN. Multiple alignments of redundant sequences were used to build reliable consensus sequences. Based on similarity to known sequences from other plant species, the isolated polynucleotide sequences were identified as encoding transcription factors, as detailed herein. The predicted polypeptide sequences corresponding to the polynucleotide sequences are also depicted therein. 
     Example 15 
     Isolation and Characterization of cDNA Clones from  Pinus Radiata    
       Pinus radiata  cDNA expression libraries (prepared from either shoot bud tissue, suspension cultured cells, early wood phloem (two independent libraries), fascicle meristem tissue, male strobilus, root (unknown lineage), feeder roots, structural roots, female strobilus, cone primordia, female receptive cones and xylem (two independent libraries) were constructed and screened as described above in Example 14. 
     DNA sequence for positive clones was obtained using forward and reverse primers on a Perkin Elmer/Applied Biosystems Division Prism 377 sequencer and the determined sequences were compared to known sequences in the database as described above. 
     Based on similarity to known sequences from other plant species, the isolated polynucleotide sequences were identified as encoding transcription factors, as detailed herein. The predicted polypeptide sequences corresponding to the polynucleotide sequences are also depicted therein. 
     Example 16 
     5′ RACE Isolation 
     To identify additional sequence 5′ or 3′ of a partial cDNA sequence in a cDNA library, 5′ and 3′ rapid amplification of cDNA ends (RACE) was performed using the SMART RACE cDNA amplification kit (Clontech Laboratories, Palo Alto, Calif.). Generally, the method entailed first isolating poly(A) mRNA, performing first and second strand cDNA synthesis to generate double stranded cDNA, blunting cDNA ends, and then ligating of the SMART RACE. Adaptor to the cDNA to form a library of adaptor-ligated ds cDNA. Gene-specific primers were designed to be used along with adaptor specific primers for both 5′ and 3′ RACE reactions. Using 5′ and 3′ RACE reactions, 5′ and 3′ RACE fragments were obtained, sequenced, and cloned. The process may be repeated until 5′ and 3′ ends of the full-length gene were identified. A full-length cDNA may generated by PCR using primers specific to 5′ and 3′ ends of the gene by end-to-end PCR. 
     For example, to amplify the missing 5′ region of a gene from first-strand cDNA, a primer was designed 5′→3′ from the opposite strand of the template sequence, and from the region between ˜100-200 bp of the template sequence. A successful amplification should give an overlap of ˜100 bp of DNA sequence between the 5′ end of the template and PCR product. 
     RNA was extracted from four pine tissues, namely seedling, xylem, phloem and structural root using the Concert Reagent Protocol (Invitrogen, Carlsbad, Calif.) and standard isolation and extraction procedures. The resulting RNA was then treated with DNase, using 10 U/ul DNase I (Roche Diagnostics, Basel, Switzerland). For 100 μg of RNA, 9 μl 10× DNase buffer (Invitrogen, Carlsbad, Calif.), 10 μl of Roche DNase I and 90 μl of Rnase-free water was used. The RNA was then incubated at room temperature for 15 minutes and 1/10 volume 25 mM EDTA is added. A RNeasy mini kit (Qiagen, Venlo, The Netherlands) was used for RNA clean up according to manufacturer&#39;s protocol. 
     To synthesize cDNA, the extracted RNA from xylem, phloem, seedling and root was used and the SMART RACE cDNA amplification kit (Clontech Laboratories Inc, Palo Alto, Calif.) was followed according to manufacturer&#39;s protocol. For the RACE PCR, the cDNA from the four tissue types was combined. The master mix for PCR was created by combining equal volumes of cDNA from xylem, phloem, root and seedling tissues. PCR reactions were performed in 96 well PCR plates, with 1 μl of primer from primer dilution plate (10 mM) to corresponding well positions. 49 μl of master mix is aliquoted into the PCR plate with primers. Thermal cycling commenced on a GeneAmp 9700 (Applied Biosystems, Foster City, Calif.) at the following parameters: 
     94° C. (5 sec), 
     72° C. (3 min), 5 cycles; 
     94° C. (5 sec), 
     70° C. (10 sec), 
     72° C. (3 min), 5 cycles; 
     94° C. (5 sec), 
     68° C. (10 sec), 
     72° C. (3 min), 25 cycles. 
     cDNA was separated on an agarose gel following standard procedures. Gel fragments were excised and eluted from the gel by using the Qiagen 96-well Gel Elution kit, following the manufacturer&#39;s instructions. 
     PCR products were ligated into pGEMTeasy (Promega, Madison, Wis.) in a 96 well plate overnight according to the following specifications: 60-80 ng of DNA, 5 μl 2× rapid ligation buffer, 0.5 μl pGEMT easy vector, 0.1 μl DNA ligase, filled to 10 μl with water, and incubated overnight. 
     Each clone was transformed into  E. coli  following standard procedures and DNA was extracted from 12 clones picked by following standard protocols. DNA extraction and the DNA quality was verified on an 1% agarose gel. The presence of the correct size insert in each of the clones was determined by restriction digests, using the restriction endonuclease EcoRI, and gel electrophoresis, following standard laboratory procedures. 
     Example 17 
     Curation of an EST Sequence. 
     During the production of cDNA libraries, the original transcripts or their DNA counterparts may have features that prevent them from coding for functional proteins. There may be insertions, deletions, base substitutions, or unspliced or improperly spliced introns. If such features exist, it is often possible to identify them so that they can be changed. Similar curation can be performed on any other sequences that have homology to sequences in the public databases. 
     After determination of the DNA sequence, BLAST analysis shows that it is related to an  Arabidopsis  gene on the publicly available  Arabidopsis  genome sequence). However, instead of coding for an approximately 240 amino acid polypeptide, the consensus being curated is predicted to code for a product of only 157 amino acid residues, suggesting an error in the DNA sequence. To identify where the genuine coding region might be, the DNA sequence to the end of each EST is translated in each of the three reading frames and the predicted sequences are aligned with the  Arabidopsis  gene&#39;s amino acid sequence. It is found that the DNA segment in one portion of the EST codes for a sequence with similarity to the carboxyl terminus of the  Arabidopsis  gene. Therefore, it appears that an unspliced intron is present in the EST. 
     Unspliced introns are a relatively minor issue with regard to use of a cloned sequence for overexpression of the gene of interest. The RNA resulting from transcription of the cDNA can be expected to undergo normal processing to remove the intron. Antisense and RNAi constructs are also expected to function to suppress the gene of interest. On other occasions, it may be desirable to identify the precise limits of the intron so that it can be removed. When the sequence in question has a published sequence that is highly similar, it may be possible to find the intron by aligning the two sequences and identifying the locations where the sequence identity falls off, aided by the knowledge that introns start with the sequence GT and end with the sequence AG. 
     When there is some doubt about the site of the intron because highly similar sequences are not available, the intron location can be verified experimentally. For example, DNA oligomers can be synthesized flanking the region where the suspected intron is located. RNA from the source species, either  Pinus  or  Eucalyptus,  is isolated and used as a template to make cDNA using reverse transcriptase. The selected primers are then used in a PCR reaction to amplify the correctly spliced DNA segment (predicted size of approximately 350 by smaller than the corresponding segment of the original consensus) from the population of cDNAs. The amplified segment is then subjected to sequence analysis and compared to the consensus sequence to identify the differences. 
     The same procedure can be used when an alternate splicing event (partial intron remaining, or partial loss of an exon) is suspected. When an EST has a small change, such as insertion or deletion of a small number of bases, computer analysis of the EST sequence can still indicate its location when a translation product of the wrong size is predicted or if there is an obvious frameshift. Verification of the true sequence is done by synthesis of primers, production of new cDNA, and PCR amplification as described above. 
     Example 18 
     Transformation of  Populus deltoides  with constructs containing cell cycle genes. 
     Constructs made as described in the preceding example and shown in Table 2 below were each inoculated into  Agrobacterium  cultures by standard techniques. 
     Table 2 identifies plasmid(s), genes, and Genesis ID numbers for constructions described in Example 17. 
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 2 
               
               
                   
                   
               
               
                   
                 Plasmid(s) 
                 Gene 
                 Genesis ID 
               
               
                   
                   
               
             
            
               
                   
                 pGrw14 
                 Cyclin A 
                 prga001823 
               
               
                   
                 pGrw15 
                 Cyclin A 
                 prpe001264 
               
               
                   
                 pGrw16 
                 Cyclin D 
                 prxa004540 
               
               
                   
                 pGrw18 
                 Cyclin D 
                 prxl006271 
               
               
                   
                 PGrw19 
                 Cyclin D 
                 prpb019661 
               
               
                   
                 PGrw20 
                 WEE1-like protein 
                 prrd041233 
               
               
                   
                   
               
            
           
         
       
     
       Populus deltoides  stock plant cultures were maintained on DKW medium (Driver and Kuniyuki, 1984, McGranahan et al. 1987, available commercially from Sigma/Aldrich) with 2.5 uM zeatin in a growth room with a 16 h photoperiod. For transformation, petioles were excised aseptically using a sharp scalpel blade from the stock plants, cut into 4-6 mm lengths, placed on DKW medium with 1 ug/ml BAP and 1 ug/ml NAA immediately after harvest, and incubated in a dark growth chamber (28 degrees) for 24 hours. 
       Agrobacterium  cultures containing the desired constructs were grown to log phase, indicated by an OD600 between 0.8-1.0 A, then pelleted and resuspended in an equal volume of  Agrobacterium  Induction Medium (AIM), which contains Woody Plant Medium salts (Lloyd, G., and McCown, B., 1981. Woody plant medium. Proc. Intern. Plant Prop. Soc. 30:421, available commercially from Sigma/Aldrich), 5 g/L glucose and 0.6 g/L MES at pH 5.8, with the addition of 1 ul of a 100 mM stock solution of acetosyringone per ml of AIM. The pellet was resuspended by vortexing. The bacterial cells were incubated for an hour in this medium at 28 degrees C. in an environmental chamber, shaking at 100 rpm. 
     After the induction period,  Populus deltoides  explants were exposed to the  Agrobacterium  mixture for 15 minutes. The explants were then lightly blotted on sterile paper towels, replaced onto the same plant medium and cultured in the dark at 18-20 degrees C. After a three-day co-cultivation period, the explants were transferred to DKW medium in which the NAA concentration was reduced to 0.1 ug/ml and to which was added 400 mg/L timentin to eradicate the  Agrobacterium.    
     After 4 days on eradication medium, explants were transferred to small magenta boxes containing the same medium supplemented with timentin (400 mg/L) as well as the selection agent geneticin (50 mg/L). Explants were transferred every two weeks to fresh selection medium. Calli that grow in the presence of selection were isolated and sub-cultured to fresh selection medium every three weeks. Calli were observed for the production of adventitious shoots. 
     Adventitious shoots were normally observed within two months from the initiation of transformation. These shoot clusters were transferred to DKW medium to which no NAA was added, and in which the BAP concentration was reduced to 0.5 ug.ml, for shoot elongation, typically for about 14 weeks. Elongated shoots were excised and transferred to BTM medium (Chalupa, Communicationes Instituti Forestalis Checosloveniae 13:7-39, 1983, available commercially from Sigma/Aldrich) at pH5.8, containing 20 g/l sucrose and 5 g/l activated charcoal. See Table 3 below. 
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Rooting medium for  Populus deltoids . 
               
            
           
           
               
               
               
            
               
                   
                 BTM-1 Media Components 
                 mg/L 
               
               
                   
                   
               
               
                   
                 NH 4 NO 3   
                 412 
               
               
                   
                 KNO 3   
                 475 
               
               
                   
                 Ca(NO 3 ) 2 •4H 2 O 
                 640 
               
               
                   
                 CaCl 2 •2H 2 O 
                  440* 
               
               
                   
                 MgSO 4 •7H 2 O 
                 370 
               
               
                   
                 KH 2 PO 4   
                 170 
               
               
                   
                 MnSO 4 •H 2 O 
                    2.3 
               
               
                   
                 ZnSO 4 •7H 2 O 
                    8.6 
               
               
                   
                 CuSO 4 •5H 2 O 
                    0.25 
               
               
                   
                 CoCl 2 •6H 2 O 
                    0.02 
               
               
                   
                 KI 
                    0.15 
               
               
                   
                 H 3 BO 3   
                    6.2 
               
               
                   
                 Na 2 MoO 4 •2H 2 O 
                    0.25 
               
               
                   
                 FeSO 4 •7H 2 O 
                   27.8 
               
               
                   
                 Na 2 EDTA•2H 2 O 
                   37.3 
               
               
                   
                 Myo-inositol 
                 100 
               
               
                   
                 Nicotinic acid 
                    0.5 
               
               
                   
                 Pyridoxine HCl 
                    0.5 
               
               
                   
                 Thiamine HCl 
                  1 
               
               
                   
                 Glycine 
                  2 
               
               
                   
                 Sucrose 
                 20000  
               
               
                   
                 Activated Carbon 
                 5000  
               
               
                   
                   
               
            
           
         
       
     
     After development of roots, typically four weeks, transgenic plants were propagated in the greenhouse by rooted cutting methods, or in vitro through axillary shoot induction for four weeks on DKW medium containing 11.4 uM zeatin, after which the multiplied shoots were separated and transferred to root induction medium. Rooted plants were transferred to soil for evaluation of growth in glasshouse and field conditions. 
     Example 19 
     Production of disproportionately large leaves mediated by ectopic expression of certain cyclin D genes 
     Approximately 100 explants of  Populus deltoides  per construct were transformed with pGRW16 and pGRW19, which contain genes that are normally show preferred expression in the vasculature, driven by a constitutive promoter (the  Pinus radiata  superubiquitin promoter). Upon regeneration, many of the ramets of many of the translines were observed to have disproportionately large leaves relative to control plants. The leaves were both longer and broader than those of control plants. 
     Disproportionately large leaves could be a very useful early indicator of growth potential large leaf size and thus high growth potential. Lage leaf size can be a function of either increased numbers of leaf cells or increased leaf cell size or both. 
     Example 20 
     Production of unusual vascular development mediated by ectopic expression of a cyclin D gene. 
     Approximately 100 explants of  Populus deltoides  per construct were transformed with pGRW18. Multiple transgenic lines regenerated from this experiment showed a very unique pleiotropic phenotype. Leaves of these transgenic lines symmetrically folded on both sides of the midrib down the entire length of the leaf. Many petioles of these lines spiraled, and in many cases turned 360 degrees, in a right-handed fashion towards the leaf. The stem showed some thickening and slight bending near the middle. 
     One ramet of the transgenic line TDL002534 showing these phenotypes was sacrificed to investigate these aberrancies at the tissue level. Transverse sections of a curling petiole stained with toluidine blue revealed retardation of vascular development, but the presence of additional vascular cylinders developing as indicated by the black arrows. The xylem and phloem within the vascular cylinders of the curling petiole appeared to be developmentally similar and spatially oriented correctly. Longitudinal sections of straight and curled petioles may offer an explanation for the spiraling phenomenon. Curled petioles showed more elongated cells on the outside turn of the curl and more compressed cells on the opposite side of the petiole. 
     Perhaps the most striking phenotype was identified in the leaves. As with the petioles, aberrant vascular development was noted, comprising additional forming vascular cylinders lateral to the larger midrib. In some sections almost fully-formed veins could be seen immediately adjacent to the midrib. In all instances where the folding phenotype was noted, this type of leaf configuration was associated with the phenotype. 
     The development of additional vascular cylinders in the space where normally a small number of vascular bundles or a single midrib are seen is indicative of unusual cell division activity at the level of early vascular development. Thus, this gene expressed under the control of a vascular-preferred promoter rather than a constitutive promoter could have utility in increasing cell division in later vascular development, creating additional wood. 
     Example 21 
     This example illustrates how polynucleotides important for wood development in  P. radiata  can be determined and how oligonucleotides which uniquely bind to those genes can be designed and synthesized for use on a microarray. 
     Open pollinated trees of approximately 16 years of age are selected from plantation-grown sites, in the United States for loblolly pine, and in New Zealand for radiata pine. Trees are felled during the spring and summer seasons to compare the expression of genes associated with these different developmental stages of wood formation. Trees are felled individually and trunk sections are removed from the bottom area approximately one to two meters from the base and within one to two meters below the live crown. The section removed from the basal end of the trunk contains mature wood. The section removed from below the live crown contains juvenile wood. Samples collected during the spring season are termed earlywood or springwood, while samples collected during the summer season are considered latewood or summerwood (Larson et al., Gen. Tech. Rep. FPL-GTR-129. Madison, Wis.: U.S. Department of Agriculture, Forest Service, Forest Products Laboratory. p. 42). 
     Tissues are isolated from the trunk sections such that phloem, cambium, developing xylem, and maturing xylem are removed. These tissues are collected only from the current year&#39;s growth ring. Upon tissue removal in each case, the material is immediately plunged into liquid nitrogen to preserve the nucleic acids and other components. The bark is peeled from the section and phloem tissue removed from the inner face of the bark by scraping with a razor blade. Cambium tissue is isolated from the outer face of the peeled section by gentle scraping of the surface. Developing xylem and lignifying xylem are isolated by sequentially performing more vigorous scraping of the remaining tissue. Tissues are transferred from liquid nitrogen into containers for long term storage at −70 until RNA extraction and subsequent analysis is performed. 
     Example 22 
     This example illustrates a procedure for RNA extraction and purification, which is particularly useful for RNA obtained from conifer needle, xylem, cambium, and phloem. 
     Tissue is obtained from conifer needle, xylem, cambium or phloem. The tissue is frozen in liquid nitrogen and ground. The total RNA is extracted using Concert Plant RNA reagent (Invitrogen). The resulting RNA sample is extracted into phenol:chloroform and treated with DNase. The RNA is then incubated at 65° C. for 2 minutes followed by centrifugation at 4° C. for 30 minutes. Following centrifugation, the RNA is extracted into phenol at least 10 times to remove contaminants. 
     The RNA is further cleaned using RNeasy columns (Qiagen). The purified RNA is quantified using RiboGreen reagent (Molecular Probes) and purity assessed by gel electrophoresis. 
     RNA is then amplified using MessageAmp (Ambion). Aminoallyl-UTP and free UTP are added to the in vitro transcription of the purified RNA at a ratio of 4:1 aminoallyl-UTP-to-UTP. The aminoallyl-UTP is incorporated into the new RNA strand as it is transcribed. The amino-allyl group is then reacted with Cy dyes to attach the colorimetric label to the resulting amplified RNA using the Amersham procedure modified for use with RNA. Unincorporated dye is removed by ethanol precipitation. The labeled RNA is quantified spectrophotometrically (NanoDrop). The labeled RNA is fragmented by heating to 95° C. as described in Hughes et al.,  Nature Biotechnol.  19:342 (2001). 
     Example 23 
     This Example illustrates how genes important for wood development in  P. radiata  can be determined and how oligonucleotides which uniquely bind to those genes can be designed and synthesized for use on a microarray. 
     Pine trees of the species  P. radiata  are grown under natural light conditions. Tissue samples are prepared as described in, e.g., Sterky et al.,  Proc. Nat&#39;l Acad. Sci.  95:13330 (1998). Specifically, tissue samples are collected from woody trees having a height of 5 meters. Tissue samples of the woody trees are prepared by taking tangential sections through the cambial region of the stem. The stems are sectioned horizontally into sections ranging from juvenile (top) to mature (bottom). The stem sections separated by stage of development are further separated into 5 layers by peeling into sections of phloem, differentiating phloem, cambium, differentiating xylem, developing xylem, and mature xylem. Tissue samples, including leaves, buds, shoots, and roots are also prepared from seedlings of the species  P. radiata.    
     RNA is isolated and ESTs generated as described in the Example above or Sterky et al., supra. The nucleic acid sequences of ESTs derived from samples containing developing wood are compared with nucleic acid sequences of genes known to be involved in polysaccharide synthesis. ESTs from samples that do not contain developing wood are also compared with sequences of genes known to be involved in the plant cell cycle. An in silico hybridization analysis is performed using BLAST (NCBI) as follows. 
     Example 24 
       Eucalyptus  in Silico Data 
     In silico gene expression can be used to determine the membership of the consensi EST libraries. For each library, a consensus is determined from the number of ESTs in any tissue class divided by the total number of ESTs in a class multiplied by 1000. These values provide a normalized value that is not biased by the extent of sequencing from a library. Several libraries were sampled for a consensus value, including reproductive, bud reproductive, bud vegetative, fruit, leaf, phloem, cambium, xylem, root, stem, sap vegetative, whole plant libraries. 
     As shown below, a number of the inventive sequences exhibit vascular-preferred expression (more than 50% of the hits by these sequences if the databases were searched at random would be in libraries made from developing vascular tissue) and thus are likely to be involved in wood-related developmental processes. The data are shown in Table 12. 
     Example 25 
       Pinus  in Silico Data 
     In silico gene expression can be used to determine the membership of the consensi EST libraries. For each library, a consensus is determined from the number of ESTs in any tissue class divided by the total number of ESTs in a class multiplied by 1000. These values provide a normalized value that is not biased by the extent of sequencing from a library. Several libraries were sampled for a consensus value, including needles, phloem, cambium, xylem, root, stem and, whole plant libraries. 
     As shown below, a number of the inventive sequences exhibit vascular-preferred expression (more than 50% of the hits by these sequences if the databases were searched at random would be in libraries made from developing vascular tissue) and thus are likely to be involved in wood-related developmental processes. The data are shown in Table 13. 
     Example 26 
     Sequences that show hybridization in silico to ESTs made from samples containing developing wood, but that do not hybridize to ESTs from samples not containing developing wood are selected for further examination. 
     cDNA clones containing sequences that hybridize to the genes showing wood-preferred expression are selected from cDNA libraries using techniques well known in the art of molecular biology. Using the sequence information, oligonucleotides are designed such that each oligonucleotide is specific for only one cDNA sequence in the library. The oligonucleotide sequences are provided in Table 14. 60-mer oligonucleotide probes are designed using the method of Li and Stormo, supra or using software such as ArrayDesigner, GeneScan, and ProbeSelect. 
     The oligonucleotides are then synthesized in situ described in Hughes et al.,  Nature Biotechnol.  19:324 (2002) or as described in Kane et al.,  Nucleic Acids Res.  28:4552 (2000) and affixed to an activated glass slide (Sigma-Genosis, The Woodlands, Tex.) using a 5′ amino linker. The position of each oligonucleotide on the slide is known. 
     Example 27 
     This example illustrates how to detect expression of  Pinus radiata  genes of the instant application which are important in wood formation using an oligonucleotide microarray prepared as described above. This is an example of a balanced incomplete block designed experiment carried out using aRNA samples prepared from mature-phase phloem (P), cambium (C), expanding xylem found in a layer below the cambium (X1) and differentiating, lignifying xylem cells found deeper in the same growth ring (X2). In this example, cell cycle gene expression is compared among the four samples, namely P, C, X1, and X2. 
     In the summer, plants of the species  Pinus radiata  are felled and the bark of the main stem is immediately pulled gently away to reveal the phloem and xylem. The phloem and xylem are then peeled with a scalpel into separate containers of liquid nitrogen. Needles (leaves) and buds from the trees are also harvested with a scalpel into separate containers of liquid nitrogen. RNA is subsequently isolated from the frozen tissue samples as described in Example 1. Equal microgram quantities of total RNA are purified from each sample using RNeasy Mini columns (Qiagen, Valencia, Calif.) according to the manufacturers instructions. 
     Amplification reactions are carried out for each of the P, C, X1, and X2 tissue samples. Amplification reactions are performed using Ambion&#39;s MessageAmp kit, a T7-based amplification procedure, following the manufacturer&#39;s instructions, except that labeled aaUTP is added to the reagent mix during in the amplification step. aaUTP is incorporated into the resulting antisense RNA formed during this step. CyDye fluorescent labels are coupled to the aaUTPs in a non-enzymatic reaction as described in Example 1. Labeled amplified antisense RNAs are precipitated and washed, and then assayed for purity using a NanoDrop spectrophotometer. These labeled antisense RNAs, corresponding to the RNA isolated from the P, C, X1, and X2 tissue samples, constitute the sample nucleic acids, which are referred to as the P, C, X1, and X2 samples. 
     Normalization control samples of known nucleic acids are added to each sample in a dilution series of 500, 200, 100, 50, 25 and 10 pg/μl for quantitation of the signals. Positive controls corresponding to specific genes showing expression in all tissues of pine, such as housekeeping genes, are also added to the plant sample. 
     Each of four microarray slides is incubated with 125 μL of a P, C, X1 or X2 sample under a coverslip at 42° C. for 16-18 hours. The arrays are washed in 1×SSC, 0.1% SDS for 10 minutes and then in 0.1×SSC, 0.1% SDS for 10 minutes and the allowed to dry. 
     The array slides are scanned using an Axon laser scanner and analyzed using GenePix Pro software. Data from the microarray slides are subjected to microarray data analysis using GenStat SAS or Spotfire software. Outliers are removed and ratiometric data for each of the datasets are normalized using a global normalization which employs a cubic spline fit applied to correct for differential dye bias and spatial effects. A second transformation is performed to fit control signal ratios to a mean log 2 =0 (i.e. 1:1 ratio). Normalized data are then subjected to a variance analysis. 
     Mean signal intensity for each signal at any given position on the microarray slide is determined for each of three of P, C, X1, and X2 sample microarray slides. This mean signal/probe position is compared to the signal at the same position on sample slide which was not used for calculating the mean. For example, a mean signal at a given position is determined for P, C, and X1 and the signal at that position in the X2 microarray slide is compared to the P, C, and X1 mean signal value. 
     Table 5 shows genes having greater than doubled signal with any one sample as compared to the mean signal of the other three samples. 
     
       
         
           
               
               
               
               
               
             
               
                   
                 TABLE 5 
               
               
                   
                   
               
               
                   
                 Gene 
                 PvCX12 
                 PvX12 
                 CvX12 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 WD40 repeat protein A 
                 −1.24 
                 −0.88 
                 −1.07 
               
               
                   
                 CDC2 
                 −1.09 
                 −0.78 
                 −0.92 
               
               
                   
                 CYCLIN 
                 −1.08 
                 −1 
                 −0.26 
               
               
                   
                 WD-40 repeat protein B 
                 −1.01 
                 −0.87 
                 −0.42 
               
               
                   
                 CDC2 
                 −0.83 
                 −0.49 
                 −1.01 
               
               
                   
                   
               
               
                   
                 P = Phloem 
               
               
                   
                 C = Cambium 
               
               
                   
                 X1 = xylem layer-1 
               
               
                   
                 X2 = xylem layer-2 
               
               
                   
                 PvCX12 = Ratio of the signal for Phloem target versus mean signal for Cambium, Xylem1, and Xylem2 targets 
               
            
           
         
       
     
     The data shows that WD40 repeat protein A encodes a WD40 repeat protein is less highly expressed in cambium than in developing xylem, while WD40 repeat protein B encodes a WD40 repeat protein that is more highly expressed in phloem than in the other tissues. 
     Signal data are then verified with RT-PCR to confirm gene expression in the target tissue of the genes corresponding to the unique oligonucleotides in the probe. 
     Example 28 
     This example illustrates how RNAs of tissues from multiple pine species, in this case both  P. radiata  and loblolly pine  P. taeda  trees, are selected for analysis of the pattern of gene expression associated with wood development in the juvenile wood and mature wood forming sections of the trees using the microarrays derived from  P. radiata  cDNA sequences described in Example 4. 
     Open pollinated trees of approximately 16 years of age are selected from plantation-grown sites, in the United States for loblolly pine, and in New Zealand for radiata pine. Trees are felled during the spring and summer seasons to compare the expression of genes associated with these different developmental stages of wood formation. Trees are felled individually and trunk sections are removed from the bottom area approximately one to two meters from the base and within one to two meters below the live crown. The section removed from the basal end of the trunk contains mature wood. The section removed from below the live crown contains juvenile wood. Samples collected during the spring season are termed earlywood or springwood, while samples collected during the summer season are considered latewood or summerwood. Larson et al.,  Gen. Tech. Rep.  FPL-GTR-129. Madison, Wis.: U.S. Department of Agriculture, Forest Service, Forest Products Laboratory. p. 42. 
     Tissues are isolated from the trunk sections such that phloem, cambium, developing xylem, and maturing xylem are removed. These tissues are collected only from the current year&#39;s growth ring. Upon tissue removal in each case, the material is immediately plunged into liquid nitrogen to preserve the nucleic acids and other components. The bark is peeled from the section and phloem tissue removed from the inner face of the bark by scraping with a razor blade. Cambium tissue is isolated from the outer face of the peeled section by gentle scraping of the surface. Developing xylem and lignifying xylem are isolated by sequentially performing more vigorous scraping of the remaining tissue. Tissues are transferred from liquid nitrogen into containers for long term storage at −70° C. until RNA extraction and subsequent analysis is performed. 
     Example 29 
     This example illustrates procedures alternative to those used in the example above for RNA extraction and purification, particularly useful for RNA obtained from a variety of tissues of woody plants, and a procedure for hybridization and data analysis using the arrays described in Example 4. 
     RNA is isolated according to the protocol of Chang et al., Plant Mol. Biol. Rep. 11:113. DNA is removed using DNase I (Invitrogen, Carlsbad, Calif.) according to the manufacturer&#39;s recommendations. The integrity of the RNA samples is determined using the Agilent 2100 Bioanalyzer (Agilent Technologies, USA). 
     10 μg of total RNA from each tissue is reverse transcribed into cDNA using known methods. 
     In the case of  Pinus radiata  phloem tissue, it can be difficult to extract sufficient amounts of total RNA for normal labelling procedures. Total RNA is extracted and treated as previously described and 100 ng of total RNA is amplified using the Ovation™ Nanosample RNA Amplification system from NuGEN™ (NuGEN, CA, USA). Similar amplification kits such as those manufactured by Ambion may alternatively be used. The amplified RNA is reverse transcribed into cDNA and labelled as described above. 
     Hybridization and stringency washes are performed using the protocol as described in the US Patent Application for “Methods and Kits for Labeling and Hybridizing cDNA for Microarray Analysis” (supra) at 42 C. The arrays (slides) are scanned using a ScanArray 4000 Microarray Analysis System (GSI Lumonics, Ottawa, ON, Canada). Raw, non-normalized intensity values are generated using QUANTARRAY software (GSI Lumonics, Ottawa, ON, Canada). 
     A fully balanced, incomplete block experimental design (Kerr and Churchill,  Gen. Res.  123:123, 2001) is used in order to design an array experiment that would allow maximum statistical inferences from analyzed data. 
     Gene expression data is analyzed using the SAS® Microarray Solution software package (The SAS Institute, Cary, N.C., USA). Resulting data was then visualized using JMP® (The SAS Institute, Cary, N.C., USA). 
     Analysis done for this experiment is an ANOVA approach with mixed model specification (Wolfinger et al.,  J. Comp. Biol.  8:625-637). Two steps of linear mixed models are applied. The first one, normalization model, is applied for global normalization at slide-level. The second one, gene model, is applied for doing rigorous statistical inference on each gene. Both models are stated in Models (1) and (2). 
       log 2 ( Y   ijkls )=θ ij   +D   k   +S   l   +DS   kl +ω ijkls    (1) 
         R   ijkls   (g) =μ ij   (g)   +D   k   (g)   +S   l   (g)   +DS   kl   (g)   +SS   ls   (g) +ε ijkls   (g)    (2) 
     Y ijkls  represents the intensity of the s th  spot in the 1 th  slide with the k th  dye applying the j th  treatment for the i th  cell line. θ ij , D k , S l , and D Skl  represent the mean effect of the jth treatment in the ith cell line, the kth dye effect, the l th  slide random effect, and the random interaction effect of the k th  dye in the l th  slide. ω ijkls  is the stochastic error term. represent the similar roles as θ ij , D k , S l , and D Skl  except they are specific for the g th  gene. R ijkls   (g)  represents the residual of the g th  gene from model (1). μ ij   (g) , D k   (g) , S l   (g) , and DS kl   (g)  represent the similar roles as θ ij , D k , S l , and DS kl  except they are specific for the g th  gene. SS ls   (g)  represent the spot by slide random effect for the g th  gene. ε ijkls   (g)  represent the stochastic error term. All random terms are assumed to be normal distributed and mutually independent within each model. 
     According to the analysis described above, certain cDNAs, some of which are shown in Table 6 below, are found to be differentially expressed. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 6 
               
               
                   
               
               
                 Gene corresponding 
                   
                   
                   
               
               
                 to SEQ ID 
                 Oligo ID 
                 Gene_Family 
                 Expression 
               
               
                   
               
             
            
               
                 162 
                 Pra_000171_O_4 
                 Peptidylprolyl isomerase 
                 steady state RNA higher 
               
               
                   
                   
                   
                 in xylem than cambium 
               
               
                 164 
                 Pra_001480_O_3 
                 Peptidylprolyl isomerase 
                 steady state RNA lower 
               
               
                   
                   
                   
                 in xylem than cambium 
               
               
                 control 
                 Pra_000218_O_2 
                 RIBONUCLEOSIDE-DIPHOSPHATE 
                 steady state RNA lower 
               
               
                   
                   
                 REDUCTASE LARGE CHAIN (EC1.17.4.1). 
                 in xylem than cambium 
               
               
                 control 
                 Pra_000193_O_2 
                 PUTATIVE SURFACE PROTEIN. 
                 steady state RNA lower 
               
               
                   
                   
                   
                 in xylem than cambium 
               
               
                   
               
            
           
         
       
     
     The involvement of these specific genes in wood development is inferred through the association of the up-regulation or down-regulation of genes to the particular stages of wood development. Both the spatial continuum of wood development across a section (phloem, cambium, developing xylem, maturing xylem) at a particular season and tree trunk position and the relationships of season and tree trunk position are considered when making associations of gene expression to the relevance in wood development. 
     Example 30 
     This example demonstrates how one can correlate polysaccharide gene expression with agronomically important wood phenotypes such as density, stiffness, strength, distance between branches, and spiral grain. 
     Mature clonally propagated pine trees are selected from among the progeny of known parent trees for superior growth characteristics and resistance to important fungal diseases. The bark is removed from a tangential section and the trees are examined for average wood density in the fifth annual ring at breast height, stiffness and strength of the wood, and spiral grain. The trees are also characterized by their height, mean distance between major branches, crown size, and forking. 
     To obtain seedling families that are segregating for major genes that affect density, stiffness, strength, distance between branches, spiral grain and other characteristics that may be linked to any of the genes affecting these characteristics, trees lacking common parents are chosen for specific crosses on the criterion that they exhibit the widest variation from each other with respect to the density, stiffness, strength, distance between branches, and spiral grain criteria. Thus, pollen from a tree exhibiting high density, low mean distance between major branches, and high spiral grain is used to pollinate cones from the unrelated plus tree among the selections exhibiting the lowest density, highest mean distance between major branches, and lowest spiral grain. It is useful to note that “plus trees” are crossed such that pollen from a plus tree exhibiting high density are used to pollinate developing cones from another plus tree exhibiting high density, for example, and pollen from a tree exhibiting low mean distance between major branches would be used to pollinate developing cones from another plus tree exhibiting low mean distance between major branches. 
     Seeds are collected from these controlled pollinations and grown such that the parental identity is maintained for each seed and used for vegetative propagation such that each genotype is represented by multiple ramets. Vegetative propagation is accomplished using micropropagation, hedging, or fascicle cuttings. Some ramets of each genotype are stored while vegetative propagules of each genotype are grown to sufficient size for establishment of a field planting. The genotypes are arrayed in a replicated design and grown under field conditions where the daily temperature and rainfall are measured and recorded. 
     The trees are measured at various ages to determine the expression and segregation of density, stiffness, strength, distance between branches, spiral grain, and any other observable characteristics that may be linked to any of the genes affecting these characteristics. Samples are harvested for characterization of cellulose content, lignin content, cellulose microfibril angle, density, strength, stiffness, tracheid morphology, ring width, and the like. RNA is then collected from replicated samples of trees showing divergent stiffness and density, or other characteristics, from genotypes that are otherwise as similar as possible in growth habit, in spring and fall so that early and late wood development is assayed. These samples are examined for gene expression similarly as described in above examples. 
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 Concensus ID Information. 
               
            
           
           
               
               
               
               
               
            
               
                 Patent app 
                 SEQ ID 
                 Gene Family 
                 Consensus_ID 
                 Expression 
               
               
                   
               
               
                 — 
                 control 
                 Ribonucleoside- 
                 pinusRadiata_000218 
                 up in early spring xylem 
               
               
                   
                   
                 diphosphate reductase 
                   
                 vs late summer xylem 
               
               
                 Cell Cycle 
                 168 
                 Peptidylprolyl 
                 pinusRadiata_001692 
                 up in juvenile 
               
               
                   
                   
                 isomerase 
                   
                 developing wood vs 
               
               
                   
                   
                   
                   
                 mature developing xylem 
               
               
                 — 
                 control 
                 Nitrite transporter 
                 pinusRadiata_016801 
                 up mature developing xylem 
               
               
                   
                   
                   
                   
                 vs juvenile cambium 
               
               
                   
               
            
           
         
       
     
     Ramets of each genotype are compared to ramets of the same genotype at different ages to establish age:age correlations for these characteristics. 
     Example 31 
     Example 8 demonstrates how responses to environmental conditions such as light and season alter plant phenotype and can be correlated to polysaccharide synthesis gene expression using microarrays. In particular, the changes in gene expression associated with wood density are examined. 
     Trees of three different clonally propagated  E. grandis  hybrid genotypes are grown on a site with a weather station that measures daily temperatures and rainfall. During the spring and subsequent summer, genetically identical ramets of the three different genotypes are first photographed with north-south orientation marks, using photography at sufficient resolution to show bark characteristics of juvenile and mature portions of the plant, and then felled. The age of the trees is determined by planting records and confirmed by a count of the annual rings. In each of these trees, mature wood is defined as the outermost rings of the tree below breast height, and juvenile wood as the innermost rings of the tree above breast height. Each tree is accordingly sectored as follows: 
     NM—NORTHSIDE MATURE 
     SM—SOUTHSIDE MATURE 
     NT—NORTHSIDE TRANSITION 
     ST—SOUTHSIDE TRANSITION 
     NJ—NORTHSIDE JUVENILE 
     SJ—SOUTHSIDE JUVENILE 
     Tissue is harvested from the plant trunk as well as from juvenile and mature form leaves. Samples are prepared simultaneously for phenotype analysis, including plant morphology and biochemical characteristics, and gene expression analysis. The height and diameter of the tree at the point from which each sector was taken is recorded, and a soil sample from the base of the tree is taken for chemical assay. Samples prepared for gene expression analysis are weighed and placed into liquid nitrogen for subsequent preparation of RNA samples for use in the microarray experiment. The tissues are denoted as follows: 
     P—phloem 
     C—cambium 
     X1—expanding xylem 
     X2—differentiating and lignifying xylem 
     Thin slices in tangential and radial sections from each of the sectors of the trunk are fixed as described in Ruzin, P LANT  M ICROTECHNIQUE AND  M ICROSCOPY,  Oxford University Press, Inc., New York, N.Y. (1999) for anatomical examination and confirmation of wood developmental stage. Microfibril angle is examined at the different developmental stages of the wood, for example juvenile, transition and mature phases of  Eucalyptus grandis  wood. Other characteristics examined are the ratio of fibers to vessel elements and ray tissue in each sector. Additionally, the samples are examined for characteristics that change between juvenile and mature wood and between spring wood and summer wood, such as fiber morphology, lumen size, and width of the S2 (thickest) cell wall layer. Samples are further examined for measurements of density in the fifth ring and determination of modulus of elasticity using techniques well known to those skilled in the art of wood assays. See, e.g., Wang, et al.,  Non - destructive Evaluations of Trees,  E XPERIMENTAL  T ECHNIQUES,  pp. 28-30 (2000). 
     For biochemical analysis, 50 grams from each of the harvest samples are freeze-dried and analyzed, using biochemical assays well known to those skilled in the art of plant biochemistry for quantities of simple sugars, amino acids, lipids, other extractives, lignin, and cellulose. See, e.g., Pettersen &amp; Schwandt,  J. Wood Chem.  &amp;  Technol.  11:495 (1991). 
     In the present example, the phenotypes chosen for comparison are high density wood, average density wood, and low density wood. Nucleic acid samples are prepared as described in Example 3, from trees harvested in the spring and summer. Gene expression profiling by hybridization and data analysis is performed as described above. 
     Using similar techniques and clonally propagated individuals one can examine polysaccharide gene expression as it is related to other complex wood characteristics such as strength, stiffness and spirality. 
     Example 32 
     Example 32 demonstrates the use of a vascular-preferred promoter functionally linked to one of the genes of the instant application. 
     A vascular-preferred promoter is then linked to one of the genes in the instant application and used to transform tree species. Boosted transcript levels of the candidate gene in the xylem of the transformants results in an increased xylem biomass phenotype. 
     In another example, a vascular-preferred promoter such as any of those in ArborGen&#39;s November 2003 patent applications is then linked to an RNAi construct containing sequences from one of the genes in the instant application and used to transform a tree of the genus from which the gene was isolated. Reduced transcript levels of the candidate gene in the xylem of the transformants results in an increased xylem biomass phenotype. 
     Example 33 
     The vector pARB476 was developed using the following steps. The Bluescript vector (Stratagene, La Jolla, Calif.) was modified by adding the Superubiquitin 3′UTR and nos 3′terminator sequence at the KpnI and ClaI sites to produce the vector pARB005 (SEQ ID NO. 773). To this vector the  P. radiata  superubiquitin promoter with intron was added. The promoter/intron sequence was first amplified from the  P. radiata  superubiquitin sequence identified in U.S. Pat. No. 6,380,459 using standard PCR techniques and the primers of SEQ ID NOS 774 and 775. The amplified fragment was then ligated into pARB005 using XbaI and PstI restriction digestion to produce the vector pARB119 (SEQ ID NO. 776). 
     The  poplus tremuloises  UDB Glucose binding domain gene (patent WO 0071670, ptCelA Genbank number AF072131) was amplified using standard PCR techniques and primers including and ATG and a ClaI site as part of the 5′ primer and a TGA and a ClaI site as part of the 3′ primer. The amplified fragment was then cloned into the ClaI site of pARB119 to produce the vector pARB476 (SEQ ID NO. 777). 
     The NotI cassette containing the  P. radiata  superubiquitin promoter with intron::UDP Glucose Binding domain::3′UTR: nos terminator from pARB476 was removed and cloned into the NotI site of pART29 to produce the vector pARB483. The binary vector pART29 is a modified pART27 vector (Gleave,  Plant Mol. Biol.  20:1203-1207, 1992) that contains the  Arabidopsis thaliana  ubiquitin 3 (UBQ3) promoter instead of the nos5′ promoter and no lacZ sequences. 
     
       
         
           
               
               
            
               
                 SEQ ID 773 
                   
               
            
           
           
               
               
            
               
                 CGATGGGTGTTATTTGTGGATAATAAATTCGGGTGATGTTCAGTGTTTGTCGTATTTCTCACGAATAAA 
                   
               
               
                   
               
               
                 TTGTGTTTATGTATGTGTTAGTGTTGTTTGTCTGTTTCAGACCCTCTTATGTTATATTTTTCTTTTCGT 
               
               
                   
               
               
                 CGGTCAGTTGAAGCCAATACTGGTGTCCTGGCCGGCACTGCAATACCATTTCGTTTAATATAAAGACTC 
               
               
                   
               
               
                 TGTTATCCGTGAGCTCGAATTTCCCCGATCGTTCAAACATTTGGCAATAAAGTTTCTTAAGATTGAATC 
               
               
                   
               
               
                 CTGTTGCCGGTCTTGCGATGATTATCATATAATTTCTGTTGAATTACGTTAAGCATGTAATAATTAACA 
               
               
                   
               
               
                 TGTAATGCATGACGTTATTTATGAGATGGGTTTTTATGATTAGAGTCCCGCAATTATACATTTAATACG 
               
               
                   
               
               
                 CGATAGAAAACAAAATATAGCGCGCAAACTAGGATAAATTATCGCGCGCGGTGTCATCTATGTTACTAG 
               
               
                   
               
               
                 ATCGCGGCCGCATTTAAATGGTACCCAATTCGCCCTATAGTGAGTCGTATTACGCGCGCTCACTGGCCG 
               
               
                   
               
               
                 TCGTTTTACAACGTCGTGACTGGGAAAACCCTGGCGTTACCCAACTTAATCGCCTTGCAGCACATCCCC 
               
               
                   
               
               
                 CTTTCGCCAGCTGGCGTAATAGCGAAGAGGCCCGCACCGATCGCCCTTCCCAACAGTTGCGCAGCCTGA 
               
               
                   
               
               
                 ATGGCGAATGGGACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGA 
               
               
                   
               
               
                 CCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCG 
               
               
                   
               
               
                 CCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACC 
               
               
                   
               
               
                 TCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTC 
               
               
                   
               
               
                 GCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACC 
               
               
                   
               
               
                 CTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGC 
               
               
                   
               
               
                 TGATTTAACAAAAATTTAACGCGAATTTTAACAAAATATTAACGCTTACAATTTAGGTGGCACTTTTCG 
               
               
                   
               
               
                 GGGAAATGTGCGCGGAACCCCTATTTGTTTATTTTTCTAAATACATTCAAATATGTATCCGCTCATGAG 
               
               
                   
               
               
                 ACAATAACCCTGATAAATGCTTCAATAATATTGAAAAAGGAAGAGTATGAGTATTCAACATTTCCGTGT 
               
               
                   
               
               
                 CGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGT 
               
               
                   
               
               
                 AAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGAT 
               
               
                   
               
               
                 CCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGCGC 
               
               
                   
               
               
                 GGTATTATCCCGTATTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTT 
               
               
                   
               
               
                 GGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGC 
               
               
                   
               
               
                 TGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCT 
               
               
                   
               
               
                 AACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGA 
               
               
                   
               
               
                 AGCCATACCAAACGACGAGCGTGACACCACGATGCCTGTAGCAATGGCAACAACGTTGCGCAAACTATT 
               
               
                   
               
               
                 AACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGC 
               
               
                   
               
               
                 AGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCG 
               
               
                   
               
               
                 TGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACAC 
               
               
                   
               
               
                 GACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAA 
               
               
                   
               
               
                 GCATTGGTAACTGTCAGACCAAGTTTACTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATT 
               
               
                   
               
               
                 TAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTT 
               
               
                   
               
               
                 CCACTGAGCGTCAGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAAT 
               
               
                   
               
               
                 CTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAAC 
               
               
                   
               
               
                 TCTTTTTCCGAAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTCCTTCTAGTGTAGCCGTA 
               
               
                   
               
               
                 GTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTGCTAATCCTGTTACCAGT 
               
               
                   
               
               
                 GGCTGCTGCCAGTGGCGATAAGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGC 
               
               
                   
               
               
                 GCAGCGGTCGGGCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACT 
               
               
                   
               
               
                 GAGATACCTACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGAAGGGAGAAAGGCGGACAGGTATCC 
               
               
                   
               
               
                 GGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGAAACGCCTGGTATCTTTA 
               
               
                   
               
               
                 TAGTCCTGTCGGGTTTCGCCACCTCTGACTTGAGCGTCGATTTTTGTGATGCTCGTCAGGGGGGCGGAG 
               
               
                   
               
               
                 CCTATGGAAAAACGCCAGCAACGCGGCCTTTTTACGGTTCCTGGCCTTTTGCTGGCCTTTTGCTCACAT 
               
               
                   
               
               
                 GTTCTTTCCTGCGTTATCCCCTGATTCTGTGGATAACCGTATTACCGCCTTTGAGTGAGCTGATACCGC 
               
               
                   
               
               
                 TCGCCGCAGCCGAACGACCGAGCGCAGCGAGTCAGTGAGCGAGGAAGCGGAAGAGCGCCCAATACGCAA 
               
               
                   
               
               
                 ACCGCCTCTCCCCGCGCGTTGGCCGATTCATTAATGCAGCTGGCACGACAGGTTTCCCGACTGGAAAGC 
               
               
                   
               
               
                 GGGCAGTGAGCGCAACGCAATTAATGTGAGTTAGCTCACTCATTAGGCACCCCAGGCTTTACACTTTAT 
               
               
                   
               
               
                 GCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCA 
               
               
                   
               
               
                 TGATTACGCCAAGCGCGCAATTAACCCTCACTAAAGGGAACAAAAGCTGGGGCCGCTCTAGAACTAGTG 
               
               
                   
               
               
                 GATCCCCCGGGCTGCAGGAATTCGTCCAGCAGTTGTCTGGAGCTCCACCAGAAATCTGGAAGCTTAT 
               
               
                   
               
            
           
           
               
               
            
               
                 SEQ ID 774 
                   
               
            
           
           
               
               
            
               
                 AAATCTAGAGGTACCATTTAAATGCGGCCGCAAAACCCCTCACAAATACATAA 
                   
               
               
                   
               
            
           
           
               
               
            
               
                 SEQ ID 775 
                   
               
            
           
           
               
               
            
               
                 TTTCTGCAGCTTGAAATTGAAATATGACTAACGAAT 
                   
               
               
                   
               
            
           
           
               
               
            
               
                 SEQ ID 776 
                   
               
            
           
           
               
               
            
               
                 tctagaggtaccatttaaatgcggccgcaaaacccctcacaaatacataaaaaaaattctttatttaat 
                   
               
               
                   
               
               
                 tatcaaactctccactacctttcccaccaaccgttacaatcctgaatgttggaaaaaactaactacatt 
               
               
                   
               
               
                 gatataaaaaaactacattacttcctaaatcatatcaaaattgtataaatatatccactcaaaggagtc 
               
               
                   
               
               
                 tagaagatccacttggacaaattgcccatagttggaaagatgttcaccaagtcaacaagatttatcaat 
               
               
                   
               
               
                 ggaaaaatccatctaccaaacttactttcaagaaaatccaaggattatagagtaaaaaatctatgtatt 
               
               
                   
               
               
                 attaagtcaaaaagaaaaccaaagtgaacaaatattgatgtacaagtttgagaggataagacattggaa 
               
               
                   
               
               
                 tcgtctaaccaggaggcggaggaattccctagacagttaaaagtggccggaatcccggtaaaaaagatt 
               
               
                   
               
               
                 aaaatttttttgtagagggagtgcttgaatcatgttttttatgatggaaatagattcagcaccatcaaa 
               
               
                   
               
               
                 aacattcaggacacctaaaattttgaagtttaacaaaaataacttggatctacaaaaatccgtatcgga 
               
               
                   
               
               
                 ttttctctaaatataactagaattttcataactttcaaagcaactcctcccctaaccgtaaaacttttc 
               
               
                   
               
               
                 ctacttcaccgttaattacattccttaagagtagataaagaaataaagtaaataaaagtattcacaaac 
               
               
                   
               
               
                 caacaatttatttcttttatttacttaaaaaaacaaaaagtttatttattttacttaaatggcataatg 
               
               
                   
               
               
                 acatatcggagatccctcgaacgagaatcttttatctccctggttttgtattaaaaagtaatttattgt 
               
               
                   
               
               
                 ggggtccacgcggagttggaatcctacagacgcgctttacatacgtctcgagaagcgtgacggatgtgc 
               
               
                   
               
               
                 gaccggatgaccctgtataacccaccgacacagccagcgcacagtatacacgtgtcatttctctattgg 
               
               
                   
               
               
                 aaaatgtcgttgttatccccgctggtacgcaaccaccgatggtgacaggtcgtctgttgtcgtgtcgcg 
               
               
                   
               
               
                 tagcgggagaagggtctcatccaacgctattaaatactcgccttcaccgcgttacttctcatcttttct 
               
               
                   
               
               
                 cttgcgttgtataatcagtgcgatattctcagagagcttttcattcaaaggtatggagttttgaagggc 
               
               
                   
               
               
                 tttactcttaacatttgtttttctttgtaaattgttaatggtggtttctgtgggggaagaatcttttgc 
               
               
                   
               
               
                 caggtccttttgggtttcgcatgtttatttgggttatttttctcgactatggctgacattactagggct 
               
               
                   
               
               
                 ttcgtgctttcatctgtgttttcttcccttaataggtctgtctctctggaatatttaattttcgtatgt 
               
               
                   
               
               
                 aagttatgagtagtcgctgtttgtaataggctcttgtctgtaaaggtttcagcaggtgtttgcgtttta 
               
               
                   
               
               
                 ttgcgtcatgtgtttcagaaggcctttgcagattattgcgttgtactttaatattttgtctccaacctt 
               
               
                   
               
               
                 gttatagtttccctcctttgatctcacaggaaccctttcttctttgagcattttcttgtggcgttctgt 
               
               
                   
               
               
                 agtaatattttaattttgggcccgggttctgagggtaggtgattattcacagtgatgtgctttccctat 
               
               
                   
               
               
                 aaggtcctctatgtgtaagctgttagggtttgtgcgttactattgacatgtcacatgtcacatattttc 
               
               
                   
               
               
                 ttcctcttatccttcgaactgatggttctttttctaattcgtggattgctggtgccatattttatttct 
               
               
                   
               
               
                 attgcaactgtattttagggtgtctctttctttttgatttcttgttaatatttgtgttcaggttgtaac 
               
               
                   
               
               
                 tatgggttgctagggtgtctgccctcttcttttgtgcttctttcgcagaatctgtccgttggtctgtat 
               
               
                   
               
               
                 ttgggtgatgaattatttattccttgaagtatctgtctaattagcttgtgatgatgtgcaggtatattc 
               
               
                   
               
               
                 gttagtcatatttcaatttcaagcgatcccccgggctgcaggaattcgtccagcagttgtctggagctc 
               
               
                   
               
               
                 caccagaaatctggaagcttatcgatgggtgttatttgtggataataaattcgggtgatgttcagtgtt 
               
               
                   
               
               
                 tgtcgtatttctcacgaataaattgtgtttatgtatgtgttagtgttgtttgtctgtttcagaccctct 
               
               
                   
               
               
                 tatgttatatttttcttttcgtcggtcagttgaagccaatactggtgtcctggccggcactgcaatacc 
               
               
                   
               
               
                 atttcgtttaatataaagactctgttatccgtgagctcgaatttccccgatcgttcaaacatttggcaa 
               
               
                   
               
               
                 taaagtttcttaagattgaatcctgttgccggtcttgcgatgattatcatataatttctgttgaattac 
               
               
                   
               
               
                 gttaagcatgtaataattaacatgtaatgcatgacgttatttatgagatgggtttttatgattagagtc 
               
               
                   
               
               
                 ccgcaattatacatttaatacgcgatagaaaacaaaatatagcgcgcaaactaggataaattatcgcgc 
               
               
                   
               
               
                 gcggtgtcatctatgttactagatcgcggccgcatttaaatggtacccaattcgccctatagtgagtcg 
               
               
                   
               
               
                 tattacgcgcgctcactggccgtcgttttacaacgtcgtgactgggaaaaccctggcgttacccaactt 
               
               
                   
               
               
                 aatcgccttgcagcacatccccctttcgccagctggcgtaatagcgaagaggcccgcaccgatcgccct 
               
               
                   
               
               
                 tcccaacagttgcgcagcctgaatggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggt 
               
               
                   
               
               
                 gtggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcccgctcctttcgctttcttc 
               
               
                   
               
               
                 ccttcctttctcgccacgttcgccggctttccccgtcaagctctaaatcgggggctccctttagggttc 
               
               
                   
               
               
                 cgatttagtgctttacggcacctcgaccccaaaaaacttgattagggtgatggttcacgtagtgggcca 
               
               
                   
               
               
                 tcgccctgatagacggtttttcgccctttgacgttggagtccacgttctttaatagtggactcttgttc 
               
               
                   
               
               
                 caaactggaacaacactcaaccctatctcggtctattcttttgatttataagggattttgccgatttcg 
               
               
                   
               
               
                 gcctattggttaaaaaatgagctgatttaacaaaaatttaacgcgaattttaacaaaatattaacgctt 
               
               
                   
               
               
                 acaatttaggtggcacttttcggggaaatgtgcgcggaacccctatttgtttatttttctaaatacatt 
               
               
                   
               
               
                 caaatatgtatccgctcatgagacaataaccctgataaatgcttcaataatattgaaaaaggaagagta 
               
               
                   
               
               
                 tgagtattcaacatttccgtgtcgcccttattcccttttttgcggcattttgccttcctgtttttgctc 
               
               
                   
               
               
                 acccagaaacgctggtgaaagtaaaagatgctgaagatcagttgggtgcacgagtgggttacatcgaac 
               
               
                   
               
               
                 tggatctcaacagcggtaagatccttgagagttttcgccccgaagaacgttttccaatgatgagcactt 
               
               
                   
               
               
                 ttaaagttctgctatgtggcgcggtattatcccgtattgacgccgggcaagagcaactcggtcgccgca 
               
               
                   
               
               
                 tacactattctcagaatgacttggttgagtactcaccagtcacagaaaagcatcttacggatggcatga 
               
               
                   
               
               
                 cagtaagagaattatgcagtgctgccataaccatgagtgataacactgcggccaacttacttctgacaa 
               
               
                   
               
               
                 cgatcggaggaccgaaggagctaaccgcttttttgcacaacatgggggatcatgtaactcgccttgatc 
               
               
                   
               
               
                 gttgggaaccggagctgaatgaagccataccaaacgacgagcgtgacaccacgatgcctgtagcaatgg 
               
               
                   
               
               
                 caacaacgttgcgcaaactattaactggcgaactacttactctagcttcccggcaacaattaatagact 
               
               
                   
               
               
                 ggatggaggcggataaagttgcaggaccacttctgcgctcggcccttccggctggctggtttattgctg 
               
               
                   
               
               
                 ataaatctggagccggtgagcgtgggtctcgcggtatcattgcagcactggggccagatggtaagccct 
               
               
                   
               
               
                 cccgtatcgtagttatctacacgacggggagtcaggcaactatggatgaacgaaatagacagatcgctg 
               
               
                   
               
               
                 agataggtgcctcactgattaagcattggtaactgtcagaccaagtttactcatatatactttagattg 
               
               
                   
               
               
                 atttaaaacttcatttttaatttaaaaggatctaggtgaagatcctttttgataatctcatgaccaaaa 
               
               
                   
               
               
                 tcccttaacgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaaggatcttcttgag 
               
               
                   
               
               
                 atcctttttttctgcgcgtaatctgctgcttgcaaacaaaaaaaccaccgctaccagcggtggtttgtt 
               
               
                   
               
               
                 tgccggatcaagagctaccaactctttttccgaaggtaactggcttcagcagagcgcagataccaaata 
               
               
                   
               
               
                 ctgtccttctagtgtagccgtagttaggccaccacttcaagaactctgtagcaccgcctacatacctcg 
               
               
                   
               
               
                 ctctgctaatcctgttaccagtggctgctgccagtggcgataagtcgtgtcttaccgggttggactcaa 
               
               
                   
               
               
                 gacgatagttaccggataaggcgcagcggtcgggctgaacggggggttcgtgcacacagcccagcttgg 
               
               
                   
               
               
                 agcgaacgacctacaccgaactgagatacctacagcgtgagctatgagaaagcgccacgcttcccgaag 
               
               
                   
               
               
                 ggagaaaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgcacgagggagcttccag 
               
               
                   
               
               
                 ggggaaacgcctggtatctttatagtcctgtcgggtttcgccacctctgacttgagcgtcgatttttgt 
               
               
                   
               
               
                 gatgctcgtcaggggggcggagcctatggaaaaacgccagcaacgcggcctttttacggttcctggcct 
               
               
                   
               
               
                 tttgctggccttttgctcacatgttctttcctgcgttatcccctgattctgtggataaccgtattaccg 
               
               
                   
               
               
                 cctttgagtgagctgataccgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgaggaag 
               
               
                   
               
               
                 cggaagagcgcccaatacgcaaaccgcctctccccgcgcgttggccgattcattaatgcagctggcacg 
               
               
                   
               
               
                 acaggtttcccgactggaaagcgggcagtgagcgcaacgcaattaatgtgagttagctcactcattagg 
               
               
                   
               
               
                 caccccaggctttacactttatgcttccggctcgtatgttgtgtggaattgtgagcggataacaatttc 
               
               
                   
               
               
                 acacaggaaacagctatgaccatgattacgccaagcgcgcaattaaccctcactaaagggaacaaaagc 
               
               
                   
               
               
                 tggggccgctctag 
               
               
                   
               
            
           
           
               
               
            
               
                 SEQ ID 777 
                   
               
            
           
           
               
               
            
               
                 TCTAGAGGTACCATTTAAATGCGGCCGCAAAACCCCTCACAAATACATAAAAAAAATTCTTTATTTAAT 
                   
               
               
                   
               
               
                 TATCAAACTCTCCACTACCTTTCCCACCAACCGTTACAATCCTGAATGTTGGAAAAAACTAACTACATT 
               
               
                   
               
               
                 GATATAAAAAAACTACATTACTTCCTAAATCATATCAAAATTGTATAAATATATCCACTCAAAGGAGTC 
               
               
                   
               
               
                 TAGAAGATCCACTTGGACAAATTGCCCATAGTTGGAAAGATGTTCACCAAGTCAACAAGATTTATCAAT 
               
               
                   
               
               
                 GGAAAAATCCATCTACCAAACTTACTTTCAAGAAAATCCAAGGATTATAGAGTAAAAAATCTATGTATT 
               
               
                   
               
               
                 ATTAAGTCAAAAAGAAAACCAAAGTGAACAAATATTGATGTACAAGTTTGAGAGGATAAGACATTGGAA 
               
               
                   
               
               
                 TCGTCTAACCAGGAGGCGGAGGAATTCCCTAGACAGTTAAAAGTGGCCGGAATCCCGGTAAAAAAGATT 
               
               
                   
               
               
                 AAAATTTTTTTGTAGAGGGAGTGCTTGAATCATGTTTTTTATGATGGAAATAGATTCAGCACCATCAAA 
               
               
                   
               
               
                 AACATTCAGGACACCTAAAATTTTGAAGTTTAACAAAAATAACTTGGATCTACAAAAATCCGTATCGGA 
               
               
                   
               
               
                 TTTTCTCTAAATATAACTAGAATTTTCATAACTTTCAAAGCAACTCCTCCCCTAACCGTAAAACTTTTC 
               
               
                   
               
               
                 CTACTTCACCGTTAATTACATTCCTTAAGAGTAGATAAAGAAATAAAGTAAATAAAAGTATTCACAAAC 
               
               
                   
               
               
                 CAACAATTTATTTCTTTTATTTACTTAAAAAAACAAAAAGTTTATTTATTTTACTTAAATGGCATAATG 
               
               
                   
               
               
                 ACATATCGGAGATCCCTCGAACGAGAATCTTTTATCTCCCTGGTTTTGTATTAAAAAGTAATTTATTGT 
               
               
                   
               
               
                 GGGGTCCACGCGGAGTTGGAATCCTACAGACGCGCTTTACATACGTCTCGAGAAGCGTGACGGATGTGC 
               
               
                   
               
               
                 GACCGGATGACCCTGTATAACCCACCGACACAGCCAGCGCACAGTATACACGTGTCATTTCTCTATTGG 
               
               
                   
               
               
                 AAAATGTCGTTGTTATCCCCGCTGGTACGCAACCACCGATGGTGACAGGTCGTCTGTTGTCGTGTCGCG 
               
               
                   
               
               
                 TAGCGGGAGAAGGGTCTCATCCAACGCTATTAAATACTCGCCTTCACCGCGTTACTTCTCATCTTTTCT 
               
               
                   
               
               
                 CTTGCGTTGTATAATCAGTGCGATATTCTCAGAGAGCTTTTCATTCAAAGGTATGGAGTTTTGAAGGGC 
               
               
                   
               
               
                 TTTACTCTTAACATTTGTTTTTCTTTGTAAATTGTTAATGGTGGTTTCTGTGGGGGAAGAATCTTTTGC 
               
               
                   
               
               
                 CAGGTCCTTTTGGGTTTCGCATGTTTATTTGGGTTATTTTTCTCGACTATGGCTGACATTACTAGGGCT 
               
               
                   
               
               
                 TTCGTGCTTTCATCTGTGTTTTCTTCCCTTAATAGGTCTGTCTCTCTGGAATATTTAATTTTCGTATGT 
               
               
                   
               
               
                 AAGTTATGAGTAGTCGCTGTTTGTAATAGGCTCTTGTCTGTAAAGGTTTCAGCAGGTGTTTGCGTTTTA 
               
               
                   
               
               
                 TTGCGTCATGTGTTTCAGAAGGCCTTTGCAGATTATTGCGTTGTACTTTAATATTTTGTCTCCAACCTT 
               
               
                   
               
               
                 GTTATAGTTTCCCTCCTTTGATCTCACAGGAACCCTTTCTTCTTTGAGCATTTTCTTGTGGCGTTCTGT 
               
               
                   
               
               
                 AGTAATATTTTAATTTTGGGCCCGGGTTCTGAGGGTAGGTGATTATTCACAGTGATGTGCTTTCCCTAT 
               
               
                   
               
               
                 AAGGTCCTCTATGTGTAAGCTGTTAGGGTTTGTGCGTTACTATTGACATGTCACATGTCACATATTTTC 
               
               
                   
               
               
                 TTCCTCTTATCCTTCGAACTGATGGTTCTTTTTCTAATTCGTGGATTGCTGGTGCCATATTTTATTTCT 
               
               
                   
               
               
                 ATTGCAACTGTATTTTAGGGTGTCTCTTTCTTTTTGATTTCTTGTTAATATTTGTGTTCAGGTTGTAAC 
               
               
                   
               
               
                 TATGGGTTGCTAGGGTGTCTGCCCTCTTCTTTTGTGCTTCTTTCGCAGAATCTGTCCGTTGGTCTGTAT 
               
               
                   
               
               
                 TTGGGTGATGAATTATTTATTCCTTGAAGTATCTGTCTAATTAGCTTGTGATGATGTGCAGGTATATTC 
               
               
                   
               
               
                 GTTAGTCATATTTCAATTTCAAGCGATCCCCCGGGCTGCAGGAATTCGTCCAGCAGTTGTCTGGAGCTC 
               
               
                   
               
               
                 CACCAGAAATCTGGAAGCTTATCGATATGGATCAGTTCCCCAAGTGGAATCCTGTCAATAGAGAAACGT 
               
               
                   
               
               
                 ATATCGAAAGGCTGTCGGCAAGGTATGAAAGAGAGGGTGAGCCTTCTCAGCTTGCTGGTGTGGATTTTT 
               
               
                   
               
               
                 TCGTGAGTACTGTTGATCCGCTGAAGGAACCGCCATTGATCACTGCCAATACAGTCCTTTCCATCCTTG 
               
               
                   
               
               
                 CTGTGGACTATCCCGTCGATAAAGTCTCCTGCTACGTGTCTGATGATGGTGCAGCTATGCTTTCATTTG 
               
               
                   
               
               
                 AATCTCTTGTAGAAACAGCTGAGTTTGCAAGGAAGTGGGTTCCGTTCTGCAAAAAATTCTCAATTGAAC 
               
               
                   
               
               
                 CAAGAGCACCGGAGTTTTACTTCTCACAGAAAATTGATTACTTGAAAGACAAGGTTCAACCTTCTTTCG 
               
               
                   
               
               
                 TGAAAGAACGTAGAGCAATGAAAAGGGATTATGAAGAGTACAAAGTCCGAGTTAATGCCCTGGTAGCAA 
               
               
                   
               
               
                 AGGCTCAGAAAACACCTGAAGAAGGATGGACTATGCAAGATGGAACACCTTGGCCTGGGAATAACACAC 
               
               
                   
               
               
                 GTGATCACCCTGGCATGATTCAGGTCTTCCTTGGAAATACTGGAGCTCGTGACATTGAAGGAAATGAAC 
               
               
                   
               
               
                 TACCTCGTCTAGTATATGTCTCCAGGGAGAAGAGACCTGGCTACCAGCACCACAAAAAGGCTGGTGCAG 
               
               
                   
               
               
                 AAAATGCTCTGGTGAGAGTGTCTGCAGTACTCACAAATGCTCCCTACATCCTCAATGTTGATTGTGATC 
               
               
                   
               
               
                 ACTATGTAAACAATAGCAAGGCTGTTCGAGAGGCAATGTGCATCCTGATGGACCCACAAGTAGGTCGAG 
               
               
                   
               
               
                 ATGTATGCTATGTGCAGTTCCCTCAGAGGTTTGATGGCATAGATAAGAGTGATCGCTACGCCAATCGTA 
               
               
                   
               
               
                 ACGTAGTTTTCTTTGATGTTAACATGAAAGGGTTGGATGGCATTCAAGGACCAGTATACGTAGGAACTG 
               
               
                   
               
               
                 GTTGTGTTTTCAACAGGCAAGCACTTTACGGCTACGGGCCTCCTTCTATGCCCAGCTTACGCAAGAGAA 
               
               
                   
               
               
                 AGGATTCTTCATCCTGCTTCTCATGTTGCTGCCCCTCAAAGAAGAAGCCTGCTCAAGATCCAGCTGAGG 
               
               
                   
               
               
                 TATACAGAGATGCAAAAAGAGAGGATCTCAATGCTGCCATATTTAATCTTACAGAGATTGATAATTATG 
               
               
                   
               
               
                 ACGAGCATGAAAGGTCAATGCTGATCTCCCAGTTGAGCTTTGAGAAAACTTTTGGCTTATCTTCTGTCT 
               
               
                   
               
               
                 TCATTGAGTCTACACTAATGGAGAATGGAGGAGTACCCGAGTCTGCCAACTCACCAACACTCATCAAGG 
               
               
                   
               
               
                 AAGCAATTCATGTCATCGGCTGTGGCTATGAAGAGAAGACTGAATGGGGAAAAGAGATTGGTTGGATAT 
               
               
                   
               
               
                 ATGGGTCAGTCACTGAGGATATCTTAAGTGGCTTCAAGATGCACTGCCGAGGATGGAGATCAATTTACT 
               
               
                   
               
               
                 GCATGCCCGTAAGGCCTGCATTCAAAGGATCTGCACCCATCAACCTGTCTGATAGATTGCACCAGGTCC 
               
               
                   
               
               
                 TCCGATGGGCTCTTGGTTCTGTGGAAATTTTCTTTAGCAGACACTGTCCCCTCTGGTACGGGTTTGGAG 
               
               
                   
               
               
                 GAGGCCGTCTTAAATGGCTCCAAAGGCTTGCGTATATAAACACCATTGTGTACCCATGAATCGATGGGT 
               
               
                   
               
               
                 GTTATTTGTGGATAATAAATTCGGGTGATGTTCAGTGTTTGTCGTATTTCTCACGAATAAATTGTGTTT 
               
               
                   
               
               
                 ATGTATGTGTTAGTGTTGTTTGTCTGTTTCAGACCCTCTTATGTTATATTTTTCTTTTCGTCGGTCAGT 
               
               
                   
               
               
                 TGAAGCCAATACTGGTGTCCTGGCCGGCACTGCAATACCATTTCGTTTAATATAAAGACTCTGTTATCC 
               
               
                   
               
               
                 GTGAGCTCGAATTTCCCCGATCGTTCAAACATTTGGCAATAAAGTTTCTTAAGATTGAATCCTGTTGCC 
               
               
                   
               
               
                 GGTCTTGCGATGATTATCATATAATTTCTGTTGAATTACGTTAAGCATGTAATAATTAACATGTAATGC 
               
               
                   
               
               
                 ATGACGTTATTTATGAGATGGGTTTTTATGATTAGAGTCCCGCAATTATACATTTAATACGCGATAGAA 
               
               
                   
               
               
                 AACAAAATATAGCGCGCAAACTAGGATAAATTATCGCGCGCGGTGTCATCTATGTTACTAGATCGCGGC 
               
               
                   
               
               
                 CGCATTTAAATGGTACCCAATTCGCCCTATAGTGAGTCGTATTACGCGCGCTCACTGGCCGTCGTTTTA 
               
               
                   
               
               
                 CAACGTCGTGACTGGGAAAACCCTGGCGTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTTTCGCC 
               
               
                   
               
               
                 AGCTGGCGTAATAGCGAAGAGGCCCGCACCGATCGCCCTTCCCAACAGTTGCGCAGCCTGAATGGCGAA 
               
               
                   
               
               
                 TGGGACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACA 
               
               
                   
               
               
                 CTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTT 
               
               
                   
               
               
                 CCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCC 
               
               
                   
               
               
                 AAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTG 
               
               
                   
               
               
                 ACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCG 
               
               
                   
               
               
                 GTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAA 
               
               
                   
               
               
                 CAAAAATTTAACGCGAATTTTAACAAAATATTAACGCTTACAATTTAGGTGGCACTTTTCGGGGAAATG 
               
               
                   
               
               
                 TGCGCGGAACCCCTATTTGTTTATTTTTCTAAATACATTCAAATATGTATCCGCTCATGAGACAATAAC 
               
               
                   
               
               
                 CCTGATAAATGCTTCAATAATATTGAAAAAGGAAGAGTATGAGTATTCAACATTTCCGTGTCGCCCTTA 
               
               
                   
               
               
                 TTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATG 
               
               
                   
               
               
                 CTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGA 
               
               
                   
               
               
                 GTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGCGCGGTATTAT 
               
               
                   
               
               
                 CCCGTATTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGT 
               
               
                   
               
               
                 ACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAA 
               
               
                   
               
               
                 CCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTT 
               
               
                   
               
               
                 TTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATAC 
               
               
                   
               
               
                 CAAACGACGAGCGTGACACCACGATGCCTGTAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCG 
               
               
                   
               
               
                 AACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCAC 
               
               
                   
               
               
                 TTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTC 
               
               
                   
               
               
                 GCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGA 
               
               
                   
               
               
                 GTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGT 
               
               
                   
               
               
                 AACTGTCAGACCAAGTTTACTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGA 
               
               
                   
               
               
                 TCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAG 
               
               
                   
               
               
                 CGTCAGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCT 
               
               
                   
               
               
                 TGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTTTTC 
               
               
                   
               
               
                 CGAAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTCCTTCTAGTGTAGCCGTAGTTAGGCC 
               
               
                   
               
               
                 ACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTGCTAATCCTGTTACCAGTGGCTGCTG 
               
               
                   
               
               
                 CCAGTGGCGATAAGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGT 
               
               
                   
               
               
                 CGGGCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACTGAGATACC 
               
               
                   
               
               
                 TACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGAAGGGAGAAAGGCGGACAGGTATCCGGTAAGCG 
               
               
                   
               
               
                 GCAGGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGAAACGCCTGGTATCTTTATAGTCCTG 
               
               
                   
               
               
                 TCGGGTTTCGCCACCTCTGACTTGAGCGTCGATTTTTGTGATGCTCGTCAGGGGGGCGGAGCCTATGGA 
               
               
                   
               
               
                 AAAACGCCAGCAACGCGGCCTTTTTACGGTTCCTGGCCTTTTGCTGGCCTTTTGCTCACATGTTCTTTC 
               
               
                   
               
               
                 CTGCGTTATCCCCTGATTCTGTGGATAACCGTATTACCGCCTTTGAGTGAGCTGATACCGCTCGCCGCA 
               
               
                   
               
               
                 GCCGAACGACCGAGCGCAGCGAGTCAGTGAGCGAGGAAGCGGAAGAGCGCCCAATACGCAAACCGCCTC 
               
               
                   
               
               
                 TCCCCGCGCGTTGGCCGATTCATTAATGCAGCTGGCACGACAGGTTTCCCGACTGGAAAGCGGGCAGTG 
               
               
                   
               
               
                 AGCGCAACGCAATTAATGTGAGTTAGCTCACTCATTAGGCACCCCAGGCTTTACACTTTATGCTTCCGG 
               
               
                   
               
               
                 CTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACG 
               
               
                   
               
               
                 CCAAGCGCGCAATTAACCCTCACTAAAGGGAACAAAAGCTGGGGCCGCTCTAG 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 8 
               
             
            
               
                   
               
               
                 pGrowth Information. 
               
            
           
           
               
               
               
               
               
            
               
                 CW AR 
                 Plasmid(s) 
                 Promoter 
                 Gene 
                 Genesis ID 
               
               
                   
               
               
                 88 
                 pGrowth14 
                 SUBIN 
                 Cyclin A 
                 prga001823 
               
               
                 88 
                 pGrowth15 
                 SUBIN 
                 Cyclin A 
                 prpe001264 
               
               
                 88 
                 pGrowth16 
                 SUBIN 
                 Cyclin D 
                 prxa004540 
               
               
                 88 
                 pGrowth18 
                 SUBIN 
                 Cyclin D 
                 prxl006271 
               
               
                 88 
                 pGrowth19 
                 SUBIN 
                 Cyclin D 
                 prpb019661 
               
               
                 88 
                 pGrowth20 
                 SUBIN 
                 WEE1-like protein 
                 prrd041233 
               
               
                   
               
            
           
         
       
     
     To make the growth100 plasmids, an acceptor vector (pWVK202) was built by first inserting the NotI-SUBIN::UDPGBD::nos term-NotI cassette from pARB483a into plasmid pWVK147 at NotI. Next, the UDPGBD gene was removed using restriction sites PstI and ClaI. A polylinker containing the restriction sites PstI, NheI, AvrII, ScaI, and ClaI was inserted in place of the UDPGBD gene. Sites AvrII and NheI are both compatible with SpeI, a site found often in the plasmids provided by Genesis. ScaI is blunt, so any fragment can be blunted and then inserted at that position into the acceptor vector. Plasmids were received from Genesis and analyzed to determine which restriction sites would be most suitable for subcloning into the acceptor vector pWVK202. After the ligations were performed, the resulting products were checked by extensive restriction digest analysis to make sure that the desired plasmid had been created. 
     
       
         
           
               
             
               
                 TABLE 9 
               
             
            
               
                   
               
               
                   Eucalyptus grandis  Cell Cycle Genes and Proteins. 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                   
                 Patent 
                 Patent 
               
               
                 DNA SEQ 
                 Protein SEQ 
                   
                 ORF 
                 ORF 
               
               
                 ID NO 
                 ID NO 
                 Sequence Identifier 
                 start 
                 stop 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 1 
                 236 
                 eucalyptusSpp_003910 
                 387 
                 1820 
               
               
                 2 
                 237 
                 eucalyptusSpp_019213 
                 99 
                 1007 
               
               
                 3 
                 238 
                 eucalyptusSpp_036800 
                 120 
                 1004 
               
               
                 4 
                 239 
                 eucalyptusSpp_040260 
                 23 
                 937 
               
               
                 5 
                 240 
                 eucalyptusSpp_041965 
                 149 
                 1033 
               
               
                 6 
                 241 
                 eucalyptusSpp_002906 
                 199 
                 1116 
               
               
                 7 
                 242 
                 eucalyptusSpp_001518 
                 41 
                 982 
               
               
                 8 
                 243 
                 eucalyptusSpp_008078 
                 291 
                 2042 
               
               
                 9 
                 244 
                 eucalyptusSpp_009826 
                 107 
                 2236 
               
               
                 10 
                 245 
                 eucalyptusSpp_010364 
                 82 
                 1749 
               
               
                 11 
                 246 
                 eucalyptusSpp_011523 
                 151 
                 1560 
               
               
                 12 
                 247 
                 eucalyptusSpp_024358 
                 82 
                 1644 
               
               
                 13 
                 248 
                 eucalyptusSpp_039125 
                 626 
                 2782 
               
               
                 14 
                 249 
                 eucalyptusSpp_005362 
                 13 
                 1467 
               
               
                 15 
                 250 
                 eucalyptusSpp_044857 
                 113 
                 1558 
               
               
                 16 
                 251 
                 eucalyptusSpp_001743 
                 187 
                 1686 
               
               
                 17 
                 252 
                 eucalyptusSpp_012405 
                 238 
                 1653 
               
               
                 18 
                 253 
                 eucalyptusSpp_003739 
                 235 
                 1539 
               
               
                 19 
                 254 
                 eucalyptusSpp_022338 
                 158 
                 1618 
               
               
                 20 
                 255 
                 eucalyptusSpp_028605 
                 205 
                 1530 
               
               
                 21 
                 256 
                 eucalyptusSpp_041006 
                 174 
                 1499 
               
               
                 22 
                 257 
                 eucalyptusSpp_006643 
                 94 
                 1332 
               
               
                 23 
                 258 
                 eucalyptusSpp_045338 
                 176 
                 1342 
               
               
                 24 
                 259 
                 eucalyptusSpp_046486 
                 150 
                 1283 
               
               
                 25 
                 260 
                 eucalyptusSpp_012070 
                 101 
                 367 
               
               
                 26 
                 261 
                 eucalyptusSpp_006617 
                 9 
                 1352 
               
               
                 27 
                 262 
                 eucalyptusSpp_007827 
                 89 
                 1486 
               
               
                 28 
                 263 
                 eucalyptusSpp_008036 
                 80 
                 1477 
               
               
                 29 
                 264 
                 010212EGLA007017HT 
                 160 
                 1062 
               
               
                 30 
                 265 
                 eucalyptusSpp_001596 
                 172 
                 1077 
               
               
                 31 
                 266 
                 eucalyptusSpp_005870 
                 66 
                 989 
               
               
                 32 
                 267 
                 eucalyptusSpp_006901 
                 111 
                 1541 
               
               
                 33 
                 268 
                 eucalyptusSpp_006902 
                 116 
                 1615 
               
               
                 34 
                 269 
                 eucalyptusSpp_007440 
                 155 
                 1453 
               
               
                 35 
                 270 
                 eucalyptusSpp_008994 
                 228 
                 2033 
               
               
                 36 
                 271 
                 eucalyptusSpp_024580 
                 110 
                 1258 
               
               
                 37 
                 272 
                 eucalyptusSpp_037831 
                 50 
                 1462 
               
               
                 38 
                 273 
                 eucalyptusSpp_034958 
                 176 
                 739 
               
               
                 39 
                 274 
                 001209EGXC004488HT 
                 150 
                 1529 
               
               
                 40 
                 275 
                 010310EGXD012820HT 
                 247 
                 1971 
               
               
                 41 
                 276 
                 010310EGXD013036HT 
                 136 
                 1644 
               
               
                 42 
                 277 
                 010316EGXF999037HT 
                 48 
                 836 
               
               
                 43 
                 278 
                 010324EGXF002118HT 
                 49 
                 822 
               
               
                 44 
                 279 
                 011019EGKA001923HT 
                 185 
                 751 
               
               
                 45 
                 280 
                 eucalyptusSpp_000966 
                 103 
                 621 
               
               
                 46 
                 281 
                 eucalyptusSpp_001037 
                 41 
                 559 
               
               
                 47 
                 282 
                 eucalyptusSpp_004603 
                 127 
                 693 
               
               
                 48 
                 283 
                 eucalyptusSpp_005465 
                 28 
                 639 
               
               
                 49 
                 284 
                 eucalyptusSpp_006571 
                 135 
                 812 
               
               
                 50 
                 285 
                 eucalyptusSpp_006786 
                 119 
                 613 
               
               
                 51 
                 286 
                 eucalyptusSpp_007057 
                 38 
                 562 
               
               
                 52 
                 287 
                 eucalyptusSpp_008670 
                 109 
                 1872 
               
               
                 53 
                 288 
                 eucalyptusSpp_009137 
                 74 
                 1159 
               
               
                 54 
                 289 
                 eucalyptusSpp_010285 
                 54 
                 2045 
               
               
                 55 
                 290 
                 eucalyptusSpp_010600 
                 53 
                 1879 
               
               
                 56 
                 291 
                 eucalyptusSpp_011551 
                 7 
                 690 
               
               
                 57 
                 292 
                 eucalyptusSpp_020743 
                 83 
                 601 
               
               
                 58 
                 293 
                 eucalyptusSpp_023739 
                 125 
                 535 
               
               
                 59 
                 294 
                 eucalyptusSpp_024103 
                 55 
                 573 
               
               
                 60 
                 295 
                 eucalyptusSpp_031985 
                 147 
                 842 
               
               
                 61 
                 296 
                 eucalyptusSpp_032025 
                 167 
                 487 
               
               
                 62 
                 297 
                 eucalyptusSpp_032173 
                 195 
                 890 
               
               
                 63 
                 298 
                 eucalyptusSpp_033340 
                 68 
                 586 
               
               
                 64 
                 299 
                 eucalyptusSpp_009143 
                 182 
                 3265 
               
               
                 65 
                 300 
                 eucalyptusSpp_000349 
                 165 
                 1145 
               
               
                 66 
                 301 
                 eucalyptusSpp_000575 
                 529 
                 1569 
               
               
                 67 
                 302 
                 eucalyptusSpp_000804 
                 156 
                 1136 
               
               
                 68 
                 303 
                 eucalyptusSpp_000805 
                 90 
                 1073 
               
               
                 69 
                 304 
                 eucalyptusSpp_000806 
                 66 
                 1049 
               
               
                 70 
                 305 
                 eucalyptusSpp_002248 
                 277 
                 1512 
               
               
                 71 
                 306 
                 eucalyptusSpp_003203 
                 33 
                 1076 
               
               
                 72 
                 307 
                 eucalyptusSpp_003209 
                 65 
                 973 
               
               
                 73 
                 308 
                 eucalyptusSpp_004429 
                 82 
                 1047 
               
               
                 74 
                 309 
                 eucalyptusSpp_004607 
                 43 
                 1101 
               
               
                 75 
                 310 
                 eucalyptusSpp_004682 
                 142 
                 1095 
               
               
                 76 
                 311 
                 eucalyptusSpp_005786 
                 61 
                 1257 
               
               
                 77 
                 312 
                 eucalyptusSpp_005887 
                 193 
                 1527 
               
               
                 78 
                 313 
                 eucalyptusSpp_005981 
                 109 
                 1155 
               
               
                 79 
                 314 
                 eucalyptusSpp_006766 
                 71 
                 1213 
               
               
                 80 
                 315 
                 eucalyptusSpp_006769 
                 109 
                 1785 
               
               
                 81 
                 316 
                 eucalyptusSpp_006907 
                 364 
                 2685 
               
               
                 82 
                 317 
                 eucalyptusSpp_007518 
                 96 
                 1412 
               
               
                 83 
                 318 
                 eucalyptusSpp_007717 
                 116 
                 1702 
               
               
                 84 
                 319 
                 eucalyptusSpp_007718 
                 46 
                 1101 
               
               
                 85 
                 320 
                 eucalyptusSpp_007741 
                 23 
                 1258 
               
               
                 86 
                 321 
                 eucalyptusSpp_007884 
                 404 
                 2644 
               
               
                 87 
                 322 
                 eucalyptusSpp_008258 
                 107 
                 2383 
               
               
                 88 
                 323 
                 eucalyptusSpp_008465 
                 243 
                 1625 
               
               
                 89 
                 324 
                 eucalyptusSpp_008616 
                 126 
                 1127 
               
               
                 90 
                 325 
                 eucalyptusSpp_008690 
                 257 
                 1390 
               
               
                 91 
                 326 
                 eucalyptusSpp_008708 
                 178 
                 1632 
               
               
                 92 
                 327 
                 eucalyptusSpp_008850 
                 290 
                 2917 
               
               
                 93 
                 328 
                 eucalyptusSpp_009072 
                 148 
                 1197 
               
               
                 94 
                 329 
                 eucalyptusSpp_009465 
                 140 
                 1567 
               
               
                 95 
                 330 
                 eucalyptusSpp_009472 
                 376 
                 1737 
               
               
                 96 
                 331 
                 eucalyptusSpp_009550 
                 69 
                 1010 
               
               
                 97 
                 332 
                 eucalyptusSpp_010284 
                 149 
                 1423 
               
               
                 98 
                 333 
                 eucalyptusSpp_010595 
                 365 
                 2677 
               
               
                 99 
                 334 
                 eucalyptusSpp_010657 
                 24 
                 923 
               
               
                 100 
                 335 
                 eucalyptusSpp_012636 
                 221 
                 3598 
               
               
                 101 
                 336 
                 eucalyptusSpp_012748 
                 44 
                 1447 
               
               
                 102 
                 337 
                 eucalyptusSpp_012879 
                 196 
                 1314 
               
               
                 103 
                 338 
                 eucalyptusSpp_015515 
                 193 
                 1668 
               
               
                 104 
                 339 
                 eucalyptusSpp_015724 
                 78 
                 1634 
               
               
                 105 
                 340 
                 eucalyptusSpp_016167 
                 85 
                 2826 
               
               
                 106 
                 341 
                 eucalyptusSpp_016633 
                 74 
                 1246 
               
               
                 107 
                 342 
                 eucalyptusSpp_017485 
                 100 
                 4377 
               
               
                 108 
                 343 
                 eucalyptusSpp_018007 
                 58 
                 2439 
               
               
                 109 
                 344 
                 eucalyptusSpp_020775 
                 159 
                 1064 
               
               
                 110 
                 345 
                 eucalyptusSpp_023132 
                 118 
                 1665 
               
               
                 111 
                 346 
                 eucalyptusSpp_023569 
                 57 
                 1628 
               
               
                 112 
                 347 
                 eucalyptusSpp_023611 
                 250 
                 1566 
               
               
                 113 
                 348 
                 eucalyptusSpp_024934 
                 106 
                 1434 
               
               
                 114 
                 349 
                 eucalyptusSpp_025546 
                 190 
                 1917 
               
               
                 115 
                 350 
                 eucalyptusSpp_030134 
                 102 
                 2942 
               
               
                 116 
                 351 
                 eucalyptusSpp_031787 
                 75 
                 1079 
               
               
                 117 
                 352 
                 eucalyptusSpp_034435 
                 99 
                 1148 
               
               
                 118 
                 353 
                 eucalyptusSpp_034452 
                 232 
                 1806 
               
               
                 119 
                 354 
                 eucalyptusSpp_035789 
                 72 
                 1124 
               
               
                 120 
                 355 
                 eucalyptusSpp_035804 
                 315 
                 2069 
               
               
                 121 
                 356 
                 eucalyptusSpp_043057 
                 145 
                 1968 
               
               
                 122 
                 357 
                 eucalyptusSpp_046741 
                 130 
                 1488 
               
               
                 123 
                 358 
                 eucalyptusSpp_047161 
                 269 
                 1693 
               
               
                 698 
                 718 
                 eucalyptusSpp_008994 
               
               
                 699 
                 719 
                 eucalyptusSpp_009143 
               
               
                 700 
                 720 
                 eucalyptusSpp_006366 
               
               
                 701 
                 721 
                 eucalyptusSpp_006907 
               
               
                 702 
                 722 
                 eucalyptusSpp_012636 
               
               
                 703 
                 723 
                 eucalyptusSpp_015724 
               
               
                 704 
                 724 
                 eucalyptusSpp_016167 
               
               
                 705 
                 725 
                 eucalyptusSpp_017485 
               
               
                 706 
                 726 
                 eucalyptusSpp_030134 
               
               
                 707 
                 727 
                 eucalyptusSpp_046741 
               
               
                 708 
                 728 
                 eucalyptusSpp_047161 
               
               
                 709 
                 729 
                 eucalyptusSpp_017378 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 10 
               
             
            
               
                   
               
               
                   Pinus radiata  cell cycle genes and proteins. 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                   
                 Patent 
                 Patent 
               
               
                 DNA SEQ 
                 Protein SEQ 
                   
                 ORF 
                 ORF 
               
               
                 ID NO 
                 ID NO 
                 Sequence Identifier 
                 start 
                 stop 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 124 
                 359 
                 pinusRadiata_001766 
                 1163 
                 2545 
               
               
                 125 
                 360 
                 pinusRadiata_002927 
                 152 
                 1582 
               
               
                 126 
                 361 
                 990309PRCA009171HT 
                 389 
                 1297 
               
               
                 127 
                 362 
                 pinusRadiata_013714 
                 38 
                 946 
               
               
                 128 
                 363 
                 pinusRadiata_016332 
                 180 
                 1088 
               
               
                 129 
                 364 
                 pinusRadiata_021677 
                 40 
                 948 
               
               
                 130 
                 365 
                 pinusRadiata_027562 
                 229 
                 1134 
               
               
                 131 
                 366 
                 pinusRadiata_001504 
                 105 
                 2642 
               
               
                 132 
                 367 
                 pinusRadiata_015211 
                 187 
                 2580 
               
               
                 133 
                 368 
                 pinusRadiata_020421 
                 220 
                 1749 
               
               
                 134 
                 369 
                 pinusRadiata_003187 
                 438 
                 1748 
               
               
                 135 
                 370 
                 pinusRadiata_015661 
                 240 
                 1631 
               
               
                 136 
                 371 
                 pinusRadiata_013874 
                 252 
                 1604 
               
               
                 137 
                 372 
                 pinusRadiata_014615 
                 261 
                 1817 
               
               
                 138 
                 373 
                 pinusRadiata_004578 
                 167 
                 1576 
               
               
                 139 
                 374 
                 pinusRadiata_023387 
                 183 
                 1598 
               
               
                 140 
                 375 
                 pinusRadiata_006970 
                 98 
                 1126 
               
               
                 141 
                 376 
                 pinusRadiata_010322 
                 148 
                 894 
               
               
                 142 
                 377 
                 pinusRadiata_022721 
                 287 
                 1363 
               
               
                 143 
                 378 
                 pinusRadiata_023407 
                 251 
                 1348 
               
               
                 144 
                 379 
                 pinusRadiata_001945 
                 229 
                 510 
               
               
                 145 
                 380 
                 pinusRadiata_008233 
                 92 
                 409 
               
               
                 146 
                 381 
                 pinusRadiata_008234 
                 64 
                 381 
               
               
                 147 
                 382 
                 pinusRadiata_022054 
                 68 
                 349 
               
               
                 148 
                 383 
                 pinusRadiata_012137 
                 125 
                 1849 
               
               
                 149 
                 384 
                 pinusRadiata_012582 
                 70 
                 1602 
               
               
                 150 
                 385 
                 pinusRadiata_015285 
                 140 
                 1465 
               
               
                 151 
                 386 
                 pinusRadiata_017229 
                 628 
                 2565 
               
               
                 152 
                 387 
                 pinusRadiata_020724 
                 55 
                 1818 
               
               
                 153 
                 388 
                 pinusRadiata_004555 
                 259 
                 1710 
               
               
                 154 
                 389 
                 pinusRadiata_004556 
                 356 
                 1807 
               
               
                 155 
                 390 
                 pinusRadiata_005729 
                 261 
                 1298 
               
               
                 156 
                 391 
                 pinusRadiata_007395 
                 365 
                 2251 
               
               
                 157 
                 392 
                 pinusRadiata_009503 
                 156 
                 1454 
               
               
                 158 
                 393 
                 pinusRadiata_011283 
                 203 
                 1348 
               
               
                 159 
                 394 
                 pinusRadiata_012322 
                 229 
                 1644 
               
               
                 160 
                 395 
                 pinusRadiata_018671 
                 156 
                 1454 
               
               
                 161 
                 396 
                 pinusRadiata_023236 
                 27 
                 2222 
               
               
                 162 
                 397 
                 pinusRadiata_000171 
                 71 
                 1759 
               
               
                 163 
                 398 
                 pinusRadiata_000172 
                 358 
                 2040 
               
               
                 164 
                 399 
                 pinusRadiata_001480 
                 238 
                 756 
               
               
                 165 
                 400 
                 pinusRadiata_001481 
                 285 
                 803 
               
               
                 166 
                 401 
                 pinusRadiata_001483 
                 190 
                 708 
               
               
                 167 
                 402 
                 pinusRadiata_001484 
                 156 
                 674 
               
               
                 168 
                 403 
                 pinusRadiata_001692 
                 176 
                 1912 
               
               
                 169 
                 404 
                 pinusRadiata_005313 
                 64 
                 765 
               
               
                 170 
                 405 
                 pinusRadiata_006362 
                 93 
                 881 
               
               
                 171 
                 406 
                 pinusRadiata_006493 
                 372 
                 1070 
               
               
                 172 
                 407 
                 pinusRadiata_006983 
                 28 
                 594 
               
               
                 173 
                 408 
                 pinusRadiata_006984 
                 34 
                 648 
               
               
                 174 
                 409 
                 pinusRadiata_007665 
                 481 
                 1611 
               
               
                 175 
                 410 
                 pinusRadiata_012196 
                 93 
                 584 
               
               
                 176 
                 411 
                 pinusRadiata_013382 
                 250 
                 1869 
               
               
                 177 
                 412 
                 pinusRadiata_016461 
                 84 
                 422 
               
               
                 178 
                 413 
                 pinusRadiata_017611 
                 128 
                 1213 
               
               
                 179 
                 414 
                 pinusRadiata_019776 
                 265 
                 837 
               
               
                 180 
                 415 
                 pinusRadiata_020659 
                 38 
                 781 
               
               
                 181 
                 416 
                 pinusRadiata_022559 
                 38 
                 526 
               
               
                 182 
                 417 
                 pinusRadiata_024188 
                 37 
                 1158 
               
               
                 183 
                 418 
                 pinusRadiata_027973 
                 61 
                 768 
               
               
                 184 
                 419 
                 pinusRadiata_001353 
                 421 
                 2172 
               
               
                 185 
                 420 
                 pinusRadiata_001978 
                 163 
                 1647 
               
               
                 186 
                 421 
                 pinusRadiata_002810 
                 192 
                 1172 
               
               
                 187 
                 422 
                 pinusRadiata_002811 
                 131 
                 1111 
               
               
                 188 
                 423 
                 pinusRadiata_002812 
                 149 
                 1726 
               
               
                 189 
                 424 
                 pinusRadiata_003514 
                 948 
                 2228 
               
               
                 190 
                 425 
                 pinusRadiata_004104 
                 332 
                 1465 
               
               
                 191 
                 426 
                 pinusRadiata_005595 
                 232 
                 1590 
               
               
                 192 
                 427 
                 pinusRadiata_005754 
                 207 
                 1550 
               
               
                 193 
                 428 
                 pinusRadiata_006463 
                 221 
                 1171 
               
               
                 194 
                 429 
                 pinusRadiata_006665 
                 221 
                 3679 
               
               
                 195 
                 430 
                 pinusRadiata_006750 
                 269 
                 1252 
               
               
                 196 
                 431 
                 pinusRadiata_007030 
                 214 
                 1242 
               
               
                 197 
                 432 
                 pinusRadiata_007854 
                 119 
                 2065 
               
               
                 198 
                 433 
                 pinusRadiata_007917 
                 186 
                 1550 
               
               
                 199 
                 434 
                 pinusRadiata_007989 
                 244 
                 3671 
               
               
                 200 
                 435 
                 pinusRadiata_008506 
                 163 
                 1431 
               
               
                 201 
                 436 
                 pinusRadiata_008692 
                 155 
                 1081 
               
               
                 202 
                 437 
                 pinusRadiata_008693 
                 537 
                 1463 
               
               
                 203 
                 438 
                 pinusRadiata_009170 
                 284 
                 1909 
               
               
                 204 
                 439 
                 pinusRadiata_009408 
                 610 
                 1659 
               
               
                 205 
                 440 
                 pinusRadiata_009522 
                 241 
                 1452 
               
               
                 206 
                 441 
                 pinusRadiata_009734 
                 223 
                 1173 
               
               
                 207 
                 442 
                 pinusRadiata_009815 
                 251 
                 1777 
               
               
                 208 
                 443 
                 pinusRadiata_010670 
                 367 
                 1419 
               
               
                 209 
                 444 
                 pinusRadiata_011297 
                 284 
                 1303 
               
               
                 210 
                 445 
                 pinusRadiata_013098 
                 684 
                 1784 
               
               
                 211 
                 446 
                 pinusRadiata_013172 
                 336 
                 2738 
               
               
                 212 
                 447 
                 pinusRadiata_013589 
                 81 
                 1622 
               
               
                 213 
                 448 
                 pinusRadiata_013608 
                 399 
                 1460 
               
               
                 214 
                 449 
                 pinusRadiata_014299 
                 207 
                 1673 
               
               
                 215 
                 450 
                 pinusRadiata_014498 
                 263 
                 1309 
               
               
                 216 
                 451 
                 pinusRadiata_014548 
                 232 
                 2529 
               
               
                 217 
                 452 
                 pinusRadiata_014610 
                 56 
                 2950 
               
               
                 218 
                 453 
                 pinusRadiata_015460 
                 56 
                 1234 
               
               
                 219 
                 454 
                 pinusRadiata_016090 
                 193 
                 2577 
               
               
                 220 
                 455 
                 pinusRadiata_016722 
                 187 
                 1233 
               
               
                 221 
                 456 
                 pinusRadiata_016785 
                 51 
                 1436 
               
               
                 222 
                 457 
                 pinusRadiata_017094 
                 525 
                 2351 
               
               
                 223 
                 458 
                 pinusRadiata_017527 
                 152 
                 1099 
               
               
                 224 
                 459 
                 pinusRadiata_017591 
                 470 
                 4114 
               
               
                 225 
                 460 
                 pinusRadiata_017769 
                 196 
                 2007 
               
               
                 226 
                 461 
                 pinusRadiata_018047 
                 214 
                 1323 
               
               
                 227 
                 462 
                 pinusRadiata_018414 
                 68 
                 2146 
               
               
                 228 
                 463 
                 pinusRadiata_018986 
                 874 
                 3705 
               
               
                 229 
                 464 
                 pinusRadiata_019479 
                 360 
                 1754 
               
               
                 230 
                 465 
                 pinusRadiata_020144 
                 185 
                 1384 
               
               
                 231 
                 466 
                 pinusRadiata_022480 
                 241 
                 1533 
               
               
                 232 
                 467 
                 pinusRadiata_023079 
                 230 
                 1435 
               
               
                 233 
                 468 
                 pinusRadiata_026739 
                 101 
                 2857 
               
               
                 234 
                 469 
                 pinusRadiata_026951 
                 43 
                 1548 
               
               
                 235 
                 470 
                 pinusRadiata_026529 
                 206 
                 1657 
               
               
                 710 
                 730 
                 pinusRadiata_000888 
               
               
                 711 
                 731 
                 pinusRadiata_004578 
               
               
                 712 
                 732 
                 pinusRadiata_007989 
               
               
                 713 
                 733 
                 pinusRadiata_009522 
               
               
                 714 
                 734 
                 pinusRadiata_014610 
               
               
                 715 
                 735 
                 pinusRadiata_017591 
               
               
                 716 
                 736 
                 pinusRadiata_017769 
               
               
                 717 
                 737 
                 pinusRadiata_026951 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 11 
               
             
            
               
                   
               
               
                 Annotated Peptide Sequences of the Present Invention. 
               
            
           
           
               
               
               
            
               
                 Entry 
                 Sequence Description 
                 Annotated Peptide Sequence 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 1 
                 The amino acid sequence of SEQ ID 
                 MGDGSLGSGGRGNSGGGGGGGSRPEWLQQ YDLIGKIGEG   
                   
               
               
                   
                 261. The conserved eukaryotic 
                 
                   TYGLVFLARIKHPSTNRGKYIAIKKFKQSKDGDGVSPTA 
                 
               
               
                   
                 protein kinase domain is 
                 
                   IREIMLLREISHENVVKLVNVHINPVDMSLYLAFDYADH 
                 
               
               
                   
                 underlined and the 
                 
                   DLYEIIRHHRDKVNQAINPYTVKSLLWQLLNGLNYLHSN 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   W IIHRDLKPSNILV MGEGEEQGVVKIADFGLARVYQAPL 
                 
               
               
                   
                 active-site signature is in bold. 
                 
                   KPLSDNGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIF 
                 
               
               
                   
                   
                 
                   AELLTLKPLFQGQEVKANPNPFQLDQLDKIFKVLGHPTQ 
                 
               
               
                   
                   
                 
                   EKWPMLVNLPHWQSDVQHIQRHKYDDNALGNVVRLSSKN 
                 
               
               
                   
                   
                   ATFDLLSKMLEYDPQKRITAAQALEHEYF RMEPLPGRNA 
               
               
                   
                   
                 LVPSSPGDKVNYPTRPVDTTTDIEGTTSLQPSQSASSGN 
               
               
                   
                   
                 AVPGNMPGPHVVTNRPMPRPMHMVGMQRVPASGMAGYNL 
               
               
                   
                   
                 NPSGMGGGMNPSGIPMQRGVANQAQQSRRKDPGMGMGGY 
               
               
                   
                   
                 PPQQKQRRF 
               
               
                   
               
               
                 2 
                 The amino acid sequence of SEQ ID 
                 MEK YQQLAK IGEGTYGIVYKAKDKKSGELLALKK IRLEA   
               
               
                   
                 262. The conserved eukaryotic 
                 
                   EDEGIPSTAIREISLLKQLQHPNIVRLYDVVHTEKKLTL 
                 
               
               
                   
                 protein kinase domain is 
                 
                   VFEFLDQDLKKYLDACGDNGLEPYTVKSFLYQLLQGIAF 
                 
               
               
                   
                 underlined and the protein kinases 
                 
                   CHEHR VLHRDLKPQNLLI NMEGELKLADFGLARAFGIPV 
                 
               
               
                   
                 ATP-binding region and 
                 
                   RNYTHEVVTLWYRAPDVLMGSRKYSTQVDIWSVGCIFAE 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   MVNGRPLFPGSSEQDQLLRIFKTLGTPSLKTWPGMAELP 
                 
               
               
                   
                 active-site signatures are in 
                 
                   DFKDNFPKYVVQSFKKICPKKLDKTGLDLLSRMLQYDPA 
                 
               
               
                   
                 bold. 
                   KRISAEQAMGHPYF KDLKLRKPKAAGPGP 
               
               
                   
               
               
                 3 
                 The amino acid sequence of SEQ ID 
                 MDQ YEKIEK IGEGTYGVVYKAIDRSTNKTIALKK IRLEQ   
               
               
                   
                 263. The conserved eukaryotic 
                 
                   EDEGVPSTAIREISLLKEMQHGNIVKLQDVVHSERRLYL 
                 
               
               
                   
                 protein kinase domain is 
                 
                   VFEYLDLDLKKHMDSCPEFSKDTHTIKMFLYQILRGISY 
                 
               
               
                   
                 underlined and the protein kinases 
                 
                   CHSHRV LHRDLKPQNLLL DRRTNSLKLADFGLARAFGIP 
                 
               
               
                   
                 ATP-binding region and 
                 
                   VRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFA 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   EMVNRRPLFPGDSEIDELFKIFRIMGTPNEDSWPGVTSL 
                 
               
               
                   
                 active-site signatures are in 
                 
                   PDFKSTFPKWASQDLKTVTPTVDPAGIDLLSKMLCMDPR 
                 
               
               
                   
                 bold. 
                   RRITAKVALEHEYF KDVGVIP 
               
               
                   
               
               
                 4 
                 The amino acid sequence of SEQ ID 
                 MVMKSKLDK YEKLEK LGEGTYGVVYKAQDKTTKEIYALK     
               
               
                   
                 264. The conserved eukaryotic 
                 
                     K IRLESEDEGIPSTAIREIALLKELQHPNVVRIHDVIHT 
                 
               
               
                   
                 protein kinase domain is 
                 
                   NKKLILVFEFVDYDLKKFLHNFDKGIDPKIVKSLLYQLV 
                 
               
               
                   
                 underlined and the protein kinases 
                 
                   RGVAHCHQQKV LHRDLKPQNLLV SQEGILKLGDFGLARA 
                 
               
               
                   
                 ATP-binding region and 
                 
                   FGIPVKNYTNEVVTLWYRAPDILLGSKNYSTSVDIWSIG 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   CIFVEMLNQKPLFPGSSEQDQLKKIFKIMGTPDATKWPG 
                 
               
               
                   
                 active-site signatures are in 
                 
                   IAELPDWKPENFEKYPGEPLNKVCPKMDPDGLDLLDKML 
                 
               
               
                   
                 bold. 
                   KCNPSERIAAKNAMSHPYF KDIPDNLKKLYN 
               
               
                   
               
               
                 5 
                 The amino acid sequence of SEQ ID 
                 MDQ YEKVEK IGEGTYGVVYKAIDRLTNETIALK KIRLEQ   
               
               
                   
                 265. The conserved eukaryotic 
                 
                   EDEGVPSTAIREISLLKEMQHGNIVRLQDVVHSENRLYL 
                 
               
               
                   
                 protein kinase domain is 
                 
                   VFEYLDLDLKKHMDSSPDFAKDPRLVKIFLYQILRGIAY 
                 
               
               
                   
                 underlined and the protein kinases 
                 
                   CHSHR VLHRDLKPQNLLI DRRTNALKLADFGLARAFGIP 
                 
               
               
                   
                 ATP-binding region and 
                 
                   VRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFA 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   EMVNQRPLFPGDSEIDELFKIFRILGTPNEDTWPGVTAL 
                 
               
               
                   
                 active-site signatures are in 
                 
                   PDFKSAFPKWPAKNLQDMVPGLNSAGIDLLSKMLCLDPS 
                 
               
               
                   
                 bold. 
                   KRITARSALEHEYF KDIGFVP 
               
               
                   
               
               
                 6 
                 The amino acid sequence of SEQ ID 
                 MEK YEKLEK VGEGTYGKVYKAKDKATGQLVALKK TRLEM   
               
               
                   
                 266. The conserved eukaryotic 
                 
                   DEEGVPPTALREVSLLQLLSQSLYVVRLLSVEHVDGGSK 
                 
               
               
                   
                 protein kinase domain is 
                 
                   RKAAAAAAAEGGGGEAHGGGAVGGGKPMLYLVFEYLDTD 
                 
               
               
                   
                 underlined and the protein kinases 
                 
                   LKKFIDSHRKGPNPRPVPAATVQNFLYQLLKGVAHCHSH 
                 
               
               
                   
                 ATP-binding region and 
                 
                   G VLHRDLKPQNLLV DKEKGILKIADLGLGRAFTVPLKSY 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   THEVFAFLAILLWRSEGESAADFDSXFRVSPVQVVTLWY 
                 
               
               
                   
                 active-site signatures are in 
                 
                   RAPEVLLGSAHYSIGVDMWSVGCIFAEMVRRQALFPGDS 
                 
               
               
                   
                 bold. 
                 
                   EFQQLLHIFRLLGTPTEKQWPGVTTLRDWHVYPQWEPQN 
                 
               
               
                   
                   
                 
                   LARAVPSLGPDGVDLLSKMLKYDPAERISAKAALDHPFF 
                 
               
               
                   
                   
                 DSLDKSQF 
               
               
                   
               
               
                 7 
                 The amino acid sequence of SEQ ID 
                 MERPATAAVSAMEA FEKLEK VGEGTYGKVYRAREKATGK     
               
               
                   
                 267. The conserved eukaryotic 
                 
                     IVALK KTRLHEDEEGVPPTTLREISILRMLSRDPHIVRL 
                 
               
               
                   
                 protein kinase domain is 
                 
                   MDVKQGQNKEGKTVLYLVFEYMETDLKKYIRGFRSSGES 
                 
               
               
                   
                 underlined and the protein kinases 
                 
                   IPVNIVKSLMYQLCKGVAFCHGHGV LHRDLKPHNLLM DK 
                 
               
               
                   
                 ATP-binding region and 
                 
                   KTLTLKIADLGLARAFTVPIKKYTHEILTLWYRAPEVLL 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   GATHYSTAVDMWSVGCIFAELVTKQALFPGDSELQQLLH 
                 
               
               
                   
                 active-site signatures are in 
                 
                   IFRLLGTPNEKMWPGVSSLMNWHEYPQWKPQSLSTAVPN 
                 
               
               
                   
                 bold. 
                   LDKDGLDLLSQMLHYEPSRRISAKAAMEHPYF DDVNKTCL 
               
               
                   
               
               
                 8 
                 The amino acid sequence of SEQ ID 
                 MGCVLGREVSSGIVTESKGRDSSEVETSKRDDSVAAKVE 
               
               
                   
                 268. The conserved eukaryotic 
                 GEGKAEEVRTEETQKKEKVEDDQQSREQRRRSKPSTKLG 
               
               
                   
                 protein kinase domain is 
                 NLPKHIRGEQVAAGWPSWLSDICGEALNGWIPRRANT FE   
               
               
                   
                 underlined and the 
                 
                   KIDKIGQGTYSNVYKAKDLLTGKIVALKKVRFDNLEPES 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   VRFMAREILILRHLDHPNVVKLEGLVTSRMSCSLYLVFE 
                 
               
               
                   
                 active-site signature is in bold. 
                 
                   YMEHDLAGLAASPAIKFTEPQVKCYMHQLLSGLEHCHNR 
                 
               
               
                   
                   
                 
                   R VLHRDIKGSNLLI DNGGVLKIGDFGLASFYDPDHKHRM 
                 
               
               
                   
                   
                 
                   TSRVVTLWYRPPELLLGANDYGVGIDLWSAGCILAELLA 
                 
               
               
                   
                   
                 
                   GKPIMPGRTEVEQLHKIYKLCGSPSEEYWKKYKLPNATL 
                 
               
               
                   
                   
                 
                   FKPREPYRRCIRETFKDFPPSSLPLIETLLAIDPAERGT 
                 
               
               
                   
                   
                   ATDALQSEFF RTEPYACEPSSLPQYPPSKEMDAKKRDDE 
               
               
                   
                   
                 ARRLRAASKGQADGSKKERTRDRRVRAVPAPEANAELQH 
               
               
                   
                   
                 NIDRRRLISHANAKSKSEKFPPPHQDGALGFPLGASHRF 
               
               
                   
                   
                 DPAVVPPDVPFTSTSFTSSKEHDQTWSGPLVDPPGAPRR 
               
               
                   
                   
                 KKHSAGGQRESSKLSMGTNKGRRADSHLKAYESKSIA 
               
               
                   
               
               
                 9 
                 The amino acid sequence of SEQ ID 
                 MYSKSSAVDDSRESPKDRVSSSRRLSEVKTSRLDSSRRE 
               
               
                   
                 269. The conserved eukaryotic 
                 NGFRARDKVGDVSVMLIDKKVNGSARFCDDQIEKKSDRL 
               
               
                   
                 protein kinase domain is 
                 QKQRRERAEAAAAADHPGAGRVPKAVEGEQVAAGWPVWL 
               
               
                   
                 underlined and the 
                 SAVAGEAIKGWLPRRADT FEKLDKIGQGTYSSVYKARDV   
               
               
                   
                 serine/threonine protein kinase 
                 
                   TNNKIVALKRVRFDNLDTESVKFMAREIHILRMLDHPNV 
                 
               
               
                   
                 active-site signature is in bold. 
                 
                   IKLEGLITSRMSCSLYLVFEYMEHDLTGLASRPDVKFSE 
                 
               
               
                   
                   
                 
                   PQIKCYMKQLLSGLDHCHKHG VLHRDIKGSNLLI DNNGI 
                 
               
               
                   
                   
                 
                   LKIADFGLASVFDPHQTAPLTSRVVTLWYRPPELLLGAS 
                 
               
               
                   
                   
                 
                   RYGVEVDLWSTGCILGELYTGKPILPGKTEVEQLHKIFK 
                 
               
               
                   
                   
                 
                   LCGSPSDDYWRRLHLPHAAVFKPPQPYRRCVAEIFKELP 
                 
               
               
                   
                   
                   PVALGLLETLISVDPSQRGTAAFALRSEFF TASPLPCDP 
               
               
                   
                   
                 SSLPKYPPSKEIDMKLREEEARRRGAAGGKNELEKRGTK 
               
               
                   
                   
                 DSRTNSAYYPNAGQLQVKQCHSNANGRSEIFGPYQEKTV 
               
               
                   
                   
                 SGFLVAPPKQARVSKETRKDYAEQPDRASFSGPLVPGPG 
               
               
                   
                   
                 FSKAGKELGHSITVSRNTNLSTLSSLVTSRTGDNKQKSG 
               
               
                   
                   
                 PLVSESANQASRYSGPIREMEPARKQDRRSHVRTNIDYR 
               
               
                   
                   
                 SREDGNSSTKEPALYGRGSAGNKIYVSGPLLVSSNNVDQ 
               
               
                   
                   
                 MLKEHDRRIQEHARRARFDKARVGNNHPQAAVDSKLVSV 
               
               
                   
                   
                 HDAG 
               
               
                   
               
               
                 10 
                 The amino acid sequence of SEQ ID 
                 MGCIPTIISDGRRRSAAPDKRRPRPRRSSSEGEAPPHAT 
               
               
                   
                 270. The conserved eukaryotic 
                 AAGSEGGESARGAPGKERPEPAPRFVVRSPQGWPPWLVA 
               
               
                   
                 protein kinase domain is 
                 AVGHAIGEFVPRCADS FRKLAKIGEGTYSNVYKARDLVT   
               
               
                   
                 underlined and the 
                 
                   GKTVALKKVRFDNLEAESIKFMAREILVLTRLNHPNVIK 
                 
               
               
                   
                 serine/threonine protein kinase 
                 
                   LEGPVTSRMSSGLYLAFEYMEHDLSGIAARQNGKFTEPQ 
                 
               
               
                   
                 active-site is in bold 
                 
                   VKCFMRQLLSGLEHCHNHD VLHRDIKCSNLLI DNEGNLK 
                 
               
               
                   
                   
                 
                   IADFGLATFYDPERKQVMTNRVVTLWYRAPELLLGATSY 
                 
               
               
                   
                   
                 
                   GIGIDLWSAGCILAELLYGKPIMPGRTEVEQLHKIFKLC 
                 
               
               
                   
                   
                 
                   GSPSEAYWNKFKLPNANIFKPPQPYARCIAETFKDFPPS 
                 
               
               
                   
                   
                   ALPLLETLLSIDPDERGTATTALNSEFF AAEPHACEPSS 
               
               
                   
                   
                 LPKYPPSKEMDLKLIKEKTRRDSSKRPSAIHGSRRDGIH 
               
               
                   
                   
                 DRAGRVIPAPEATAENQATLHRPRAMKKANPMSRSEKFP 
               
               
                   
                   
                 PAHMDGVVGSSANAWLSGPASNAAPDSRRHRSLNQNPSS 
               
               
                   
                   
                 SVGKASTGSSTTQETLKVAPELLQVGSSSLHPCHRMLVY 
               
               
                   
                   
                 GSNLTIRSK 
               
               
                   
               
               
                 11 
                 The amino acid sequence of SEQ ID 
                 MGCICAKQADRGPASPGSGILTGAGTGTGTRSSKIPSGL 
               
               
                   
                 271. The conserved protein kinase 
                 FEFEKSGVKEHGGRSGELRKLEEKGSLSKRLRLELGFSH 
               
               
                   
                 family domain is underlined, and 
                 RYVEAEQAAAGWPSWLTAVAGDAIQGLVPLKADS FEKLE   
               
               
                   
                 the serine/threonine protein 
                 
                   KIGQGTYSSVFRARELANGRMVALKKVRFDNFQPESIQF 
                 
               
               
                   
                 kinases active-site signature is 
                 
                   MAREISILRRLDHPNIMKLEGIITSRMSNSIYLVFEYME 
                 
               
               
                   
                 in bold 
                 
                   HDLYGLISSPQVKFSDAQVKCYMKQLLSGIEHCHQHGVI 
                 
               
               
                   
                   
                 
                     HRDVKSSNILV NNEGILRIGDFGLANILNPKDRQQLTSH 
                 
               
               
                   
                   
                 
                   VVTLWYRPPELLMGSTSYGVTVDLWSVGCVFAELMFRKP 
                 
               
               
                   
                   
                 
                   ILRGRTEVEQLHKIFKLCGSPPDGYWKMCKVPQATMFRP 
                 
               
               
                   
                   
                 
                   RHAYECTLRERCKGIATSAMKLMETFLSIEPHKRGTASS 
                 
               
               
                   
                   
                   ALISEYF RTVPYACDPSSLPKYPPNKEIDAKHREEARRK 
               
               
                   
                   
                 KARSRVREAEVGKRPTRIHRASQEQGFSSNIAPKEKRSYA 
               
               
                   
               
               
                 12 
                 The amino acid sequence of SEQ ID 
                 MAVAAPGHLNVNESPSWGSRSVDC FEKLEQ IGEGTYGQV     
               
               
                   
                 272. The conserved eukaryotic 
                 
                     YMAKEKKTGEIVALKK IRMDNEREGFPITAIREIKILKK 
                 
               
               
                   
                 protein kinase domain is 
                 
                   LHHENVIKLKEIVTSPGPEKDEQGRPEGNKYKGGIYMVF 
                 
               
               
                   
                 underlined and the protein kinases 
                 
                   EYMDHDLTGLADRPGMRFSVPQIKCYMRQLLTGLHYCHI 
                 
               
               
                   
                 ATP-binding region and 
                 
                   NQV LHRDIKGSNL LIDNEGNLKLADFGLARSFSNDHNAN 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   LTNRVITLWYRPPELLLGATKYGPAVDMWSVGCIFAELL 
                 
               
               
                   
                 active-site signatures are in 
                 
                   HGKPIFPGKDEPEQLNKIFELCGAPDEINWPGVSKIPWY 
                 
               
               
                   
                 bold. 
                 
                   NNFKPTRPMKRRLREVFRHFDRHALELLERMLTLDPSQR 
                 
               
               
                   
                   
                   ISAKDALDAEYF WADPLPCDPKSLPKYESSHEFQTKKKR 
               
               
                   
                   
                 QQQRQHEETAKRQKLQHPPQHPRLPPVQQSGQAHAQMRP 
               
               
                   
                   
                 GPNQLMHGSQPPVATGPPGHHYGKPRGPSGGAGRYPSSG 
               
               
                   
                   
                 NPGGGYNHPSRGGQGGSGGYNSGPYPPQGRAPPYGSSGM 
               
               
                   
                   
                 PGAGPRGGGGNNYGVGPSNYPQGGGGPYGGSGAGRGSNM 
               
               
                   
                   
                 MGGNRNQQYGWQQ 
               
               
                   
               
               
                 13 
                 The amino acid sequence of SEQ ID 
                 MGCICTKGILPAHYRIKDGGLKLSKSSKRSVGSLRRDEL 
               
               
                   
                 273. The conserved 
                 AVSANGGGNDAADRLISSPHEVENEVEDRKNVDFNEKLS 
               
               
                   
                 serine/threonine protein kinase 
                 KSLQRRATMDVASGGHTQAQLKVGKVGGFPLGERGAQVV 
               
               
                   
                 domain is underlined, and the 
                 AGWPSWLTAVAGEAINGWVPRRADS FEKLEKIGQGTYSS   
               
               
                   
                 serine/threonine protein kinase 
                 
                   VYRARDLETNTIVALKKVRFANMDPESVRFMAREIIIMR 
                 
               
               
                   
                 active-site signature is in bold. 
                 
                   KLDHPNVMKLEGLITSRVSGSLYLVFEYMDHDLAGLAAT 
                 
               
               
                   
                   
                 
                   PSIKLTESQIKCYMQQLLRGLEYCHSHG VLHRDIKGSNL   
                 
               
               
                   
                   
                 
                     LV DNNGNLKIGDFGLATFFRTNQKQPLTSRVVTLWYRPP 
                 
               
               
                   
                   
                 
                   ELLLGSSDYGASVDLWSSGCILAELFAGKPIMPGRTEVE 
                 
               
               
                   
                   
                 
                   QLHKIFKLCGSPSEEYWKKSKLPHATIFKPQQPYKRCLL 
                 
               
               
                   
                   
                   ETFKDFPSSALGLLDVLLAVEPECRGTASSALQNEFF TS 
               
               
                   
                   
                 NPLPSDPSSLPKYPSSKEFDARLRDEEARKHKATAGKAR 
               
               
                   
                   
                 GLESIRKGSKESKVVPTSNANADLKASIQKRQEQSNPRS 
               
               
                   
                   
                 TGEKPGGTTQNNFILSGQSAKPSLNGSTQIGNANEVEAL 
               
               
                   
                   
                 IVPDRELDSPRGGAELRRQRSFMQRRASQLSRFSNSVAV 
               
               
                   
                   
                 GGDSHLDCSREKGANTQWRDEGFVARCSHPDGGELAGKH 
               
               
                   
                   
                 DWSHHLLHRPISLFKKGGEHSRRDSIASYSPKKGRIHYS 
               
               
                   
                   
                 GPLLPSGDNLDEMLKEHERQIQNAVRKARLDKVKTKREY 
               
               
                   
                   
                 ADHGQTESLLCWANGR 
               
               
                   
               
               
                 14 
                 The amino acid sequence of SEQ ID 
                 MDPDPSPDPDPPKSWSIHTRREIIAR YEILERVGSGAYS   
               
               
                   
                 274. The conserved protein kinase 
                 
                   DVYRGRRLSDGLAVALKEVHDYQSAFREIEALQILRGSP 
                 
               
               
                   
                 family domain is underlined and 
                 
                   HVVLLHEYFWREDEDAVLVLEFLRSDLAAVIADASRRPR 
                 
               
               
                   
                 the serine/threonine protein 
                 
                   DGGGGGAAALRAGEVKRWMLQVLEGVDACHRNS IVHRDL   
                 
               
               
                   
                 kinases active-site signature is 
                 
                     KPGNLLI SEEGVLKIADFGQARILLDDGNVAPDYEPESF 
                 
               
               
                   
                 in bold. 
                 
                   EERSSEQADILQQPETMEADTTCPEGQEQGAITREAYLR 
                 
               
               
                   
                   
                 
                   EVDEFKAKNPRHEIDKETSIFDGDTSCLATCTTSDIGED 
                 
               
               
                   
                   
                 
                   PFKGSYVYGAEEAGEDAQGCLTSCVGTRWFRAPELLYGS 
                 
               
               
                   
                   
                 
                   TDYGLEVDLWSLGCIFAELLTLEPLFPGISDIDQLSRIF 
                 
               
               
                   
                   
                 
                   NVLGNLSEEVWPGCTKLPDYRTISFCKIENPIGLESCLP 
                 
               
               
                   
                   
                   NCSSDEVSLVRRLLCYDPAARATPMELLQDKYF TEEPLP 
               
               
                   
                   
                 VPISALQVPQSKNSHDEDSAGGWYDYNDMDSDSDFEDFG 
               
               
                   
                   
                 PLKFTPTSTGFSIQFP 
               
               
                   
               
               
                 15 
                 The amino acid sequence of SEQ ID 
                 MDPDPSPSPDPPKSWSIHTRREIIAR YEILERVGSGAYS   
               
               
                   
                 275. The conserved 
                 
                   DVYRGRRLSDGLAVALKEVHDYQSAFREIEALQILRGSP 
                 
               
               
                   
                 serine/threonine protein kinase 
                 
                   HVVLLHEYFWREDEDAVLVLEFLRSDLAAVIADASRRPR 
                 
               
               
                   
                 domain is underlined, and the 
                 
                   GGGVAPLRAGEGKRWMLQVLEGVDACHRNS IVHRDLKPG   
                 
               
               
                   
                 serine/threonine protein kinase 
                 
                     NLLI SEEGVLKIADFGQARILLDDGNVAPDYEPESFEER 
                 
               
               
                   
                 active-site signature is in bold. 
                 
                   SSEQADILQQPETMEADTTCPEGQEQGAITREAYLREVD 
                 
               
               
                   
                   
                 
                   EFKAKNPRHEIDKETSIYDGDTSCLATCTTSDIGEDPFK 
                 
               
               
                   
                   
                 
                   GSYVYGAEEAGEDAQGSLTSCVGTRWFRAPELLYGSTDY 
                 
               
               
                   
                   
                 
                   GLEVDLWSLGCIFAELLTLEPLFPGISDIDQLSRIFNVL 
                 
               
               
                   
                   
                 
                   GNLSEEVWPGCTKLPDYRTISFCKIENPIGLESCLPNCS 
                 
               
               
                   
                   
                   SDEVSLVRRLLCYDPAARATPMELLQDKYF TEEPLPVPI 
               
               
                   
                   
                 SALQVPQSKNSHDEDSAGGWYDYNDMDSDSDFEDFGPLK 
               
               
                   
                   
                 FTPTSTGFSIQFP 
               
               
                   
               
               
                 16 
                 The amino acid sequence of SEQ ID 
                 MSNQHRRSSFSSSTTSSLAKRHASSSSSSLENAGKAFAA 
               
               
                   
                 276. The conserved cyclin and 
                 AAVPSHLAKKRAPLGNLTNLKAGDGNSRSSSAPSTLVAN 
               
               
                   
                 cyclin C-terminal domains are 
                 ATKLAKTRKGSSTSSSIMGLSGSALPRYASTKPSGVLPS 
               
               
                   
                 underlined and the cyclins 
                 VNPSIPRIEIAVDPMSCSMVVSPSRSDMQSVSLDESMST 
               
               
                   
                 signature is in bold. 
                 CESFKSPDVEYIDNEDVSAVDSIDRKTFSNLYISDAAAK 
               
               
                   
                   
                 TAVNICERDVLMEMETDEKIVNVDDNYSDPQLCATIAC D   
               
               
                   
                   
                 
                   IYQHLRASEAKKRPSTDFMDRVQKDITASM RAILIDWLV   
                 
               
               
                   
                   
                 
                     EVAEEYRLVPDTLYLTVNYIDRY LSGNVMNRQRLQLLGV 
                 
               
               
                   
                   
                 
                   ACMMIAAKYEEICAPQVEEFCYITDNTYFKEEVLQMESS 
                 
               
               
                   
                   
                 
                   VLNYLKFEMTAPTVKCFLRRFVRAAQGVNEVPSLQLECM 
                 
               
               
                   
                   
                 
                   ANYIAELSLLEYDMLCYAPSLVAASAIFLAKFVITPSKR 
                 
               
               
                   
                   
                 
                   PWDPTLQHYTLYQPSDLGNCVKDLHRLCFNNHGSTLPAI 
                 
               
               
                   
                   
                   REKYSQHKYKYVAKKYCPPSIP PEFFHNLVY 
               
               
                   
               
               
                 17 
                 The amino acid sequence of SEQ ID 
                 MNKENAVGTKSEAPTIRITRSRSKALGTSTGMLPSSRPS 
               
               
                   
                 277. The conserved cyclin and 
                 FKQEQKRTVRANAKRSASDENKGTMVGNASKQHKKRTVL 
               
               
                   
                 cyclin C-terminal domains are 
                 NDVTNIFCENSYSNCLNAAKAQTSRQGRKWSMKKDRDVH 
               
               
                   
                 underlined. 
                 QSGAVQIMQEDVQAQFVEESSKIKVAESMEITIPDKWAK 
               
               
                   
                   
                 RENSEHSISMKDTVAESSRKPQEFICGEKSAALVQPSIV 
               
               
                   
                   
                 DIDSKLEDPQACTPYAL DIYNYKRSTELERRPSTIYMET   
               
               
                   
                   
                 
                   LQKDVTPNMRGILVDWLVEVSEEYKLVPDTLYLTVNLID 
                 
               
               
                   
                   
                 
                   RSLSQKFIEKQRLQLLGVTCMLIASKYEEICPPRVEEFC 
                 
               
               
                   
                   
                 
                   FITDNTYTSLEVLKMESRVLNLLHFQLSVPTVKTFLRRF 
                 
               
               
                   
                   
                 
                   VQAAQVSSEVPSVELEYLANYLAELTLVEYSFLKFLPSL 
                 
               
               
                   
                   
                 
                   MAASAVLLARWTLNQSDNPWNLTLEHYTKYKASELKAAV 
                 
               
               
                   
                   
                 
                   LALEDLQLNTSGSTLNAIREKYRQQKVNYSLLIHSKANH 
                 
               
               
                   
                   
                 EIL 
               
               
                   
               
               
                 18 
                 The amino acid sequence of SEQ ID 
                 MAGSDENNPGVVGGAHVQEGLRVGAGKMGAGNVQQRRAL 
               
               
                   
                 278. The conserved cyclin N- and 
                 SNINSNIIGAPPYPCAVNKRVLSEKNVNSENDLLNAAHR 
               
               
                   
                 C-terminal family domains are 
                 PITRQFAAQMAYKQQLRPEENKRTTQSVSNPSKSEDCAI 
               
               
                   
                 underlined and the cyclins 
                 LDVDDDKMADDFPVPMFVQHTEAMLEEIDRMEEVEMEDV 
               
               
                   
                 signature is in bold. 
                 AEEPVTDIDSGDKENQLAVVEYID DLYMFYQKAEASSCV   
               
               
                   
                   
                 
                   PPNYMDRQQDINERM RGILIDWLIEVHYKFELMDETLYL   
                 
               
               
                   
                   
                 
                     TVNLIDRF LAVQPVVKKKLQLVGVTAMLLACKYEEVSVP 
                 
               
               
                   
                   
                 
                   VVEDLILISDRAYSRKEVLEMERLMVNTLHFNMSVPTPY 
                 
               
               
                   
                   
                 
                   VFMRRFLKAAQSDKKLELLSFFIIELSLVEYDMLKFPPS 
                 
               
               
                   
                   
                 
                   LLAASAIYTALSTITRTKQWSTTCEWHTSYSEEQLLECA 
                 
               
               
                   
                   
                 
                   RLMVTFHQRAGSGKLTGVHRKYSTSKFGHAARTEPANFL 
                 
               
               
                   
                   
                 LDFRL 
               
               
                   
               
               
                 19 
                 The amino acid sequence of SEQ ID 
                 MASRPIVPVQARGEAAIGGGAGKAAIGGGAGKQQKKNGA 
               
               
                   
                 279. The conserved cyclin and 
                 AEGRNRKALGDIGNLVTVRGIEGKVQPHRPITRSFCAQL 
               
               
                   
                 cyclin C-terminal domains are 
                 LANAQAAAAAENNKKQAVVNVNGAPSILDVPGAGKRAEP 
               
               
                   
                 underlined. 
                 AAAAAAAVAKAAQKKVVKPKQKAEVIDLTSDSEERSRPR 
               
               
                   
                   
                 RSN NIMSLRRRKERNHREGICPLSLRSSLLEARLVDWLI   
               
               
                   
                   
                 
                   EIHNKFDLMPETLYLTINIIDRFLSVKAVPRRELQLLGM 
                 
               
               
                   
                   
                 
                   GALFTASKYEEIWAPEVNDLVCIADRAYSHEQVLAMEKT 
                 
               
               
                   
                   
                 
                   ILGKLEWTLTVPTHYVFLVRFIKASLGDRKLENMVYFLA 
                 
               
               
                   
                   
                 
                   ELGVMNYATLTYCPSMVAASAVYAARCTLGLTPLWNDTL 
                 
               
               
                   
                   
                 
                   KLHTGFSESQLMDCARLLVGYHAKAKENKLQVVYKKYSS 
                 
               
               
                   
                   
                   SQREGVALIPPAKALL CEGGGLSSSSSLASSS 
               
               
                   
               
               
                 20 
                 The amino acid sequence of SEQ ID 
                 MGLPDENNAALSKPTNLQVGGLEIGGRKFGQEIRQTRRA 
               
               
                   
                 280. The conserved cyclin and 
                 LSVINQNLVGDRAYPCHVVNKRGHSKRDAVCGKDQVDPV 
               
               
                   
                 cyclin C-terminal domains are 
                 HRPLTRKFAAQTASTQQHCIEEAKKPRTAVQERNEFGDC 
               
               
                   
                 underlined and the cyclins 
                 IFVDVEDCQPSSENQPVPMFLEIPESRLDDDMEEVEMED 
               
               
                   
                 signature is in bold. 
                 IVEEEEEEPIMDIDGRDKKNPLAVVDYIE DIYANYRRTE   
               
               
                   
                   
                 
                   NCSCVSANYMAQQADINEKM RSILIDWLIEVHDKFDLMH   
                 
               
               
                   
                   
                 
                     ETLFLTVNLIDRF LARQSVVRKKLQLVGLVAMLLACKYE 
                 
               
               
                   
                   
                 
                   EVSVPVVGDLILISDKAYTRKEVLEMESLMLNSLQFNMS 
                 
               
               
                   
                   
                 
                   VPTPYVFMRRFLKAAESDKKLEVLSFFLIELSLVEYEMV 
                 
               
               
                   
                   
                 
                   KFPPSLLAAAAIFTAQCTLYGFKQWTKTCEWHSNYTEDQ 
                 
               
               
                   
                   
                 
                   LLECARMMVGFHQKAATGKLTGVHRKYGTSKFGYTSKCE 
                 
               
               
                   
                   
                   PANFL LGEMKNP 
               
               
                   
               
               
                 21 
                 The amino acid sequence of SEQ ID 
                 MGLPDENNAALSKPTNLQVGGLEIGGRKFGQEIRQTRRA 
               
               
                   
                 281. The conserved cyclin and 
                 LSVINQNLVGDRAYPCHVVNKRGHSKRDAVCGKDQVDPV 
               
               
                   
                 cyclin C-terminal domains are 
                 HRPLTRKFAAQTASTQQHCIEEAKKPRTAVQERNEFGDC 
               
               
                   
                 underlined and the cyclins 
                 IFVDVEDCQPSSENQPVPMFLEIPESRLDDDMEEVEMED 
               
               
                   
                 signature is in bold. 
                 IVEEEEEEPIMDIDGRDKKNPLAVVDYIE DIYANYRRTE   
               
               
                   
                   
                 
                   NCSCVSANYMAQQADINEKM RSILIDWLIEVHDKFDLMH   
                 
               
               
                   
                   
                 
                     ETLFLTVNLIDRF LARQSVVRKKLQLVGLVAMLLACKYE 
                 
               
               
                   
                   
                 
                   EVSVPVVGDLILISDKAYTRKEVLEMEKLMLNSLQFNMS 
                 
               
               
                   
                   
                 
                   VPTPYVFMRRFLKAAESDKKLEVLSFFLIELSLVEYEMV 
                 
               
               
                   
                   
                 
                   KFPPSLLAAAAIFTAQCTLYGFKQWTKTCEWHSNYTEDQ 
                 
               
               
                   
                   
                 
                   LLECARMMVGFHQKAATGKLTGVHRKYGTSKFGYTSKCE 
                 
               
               
                   
                   
                   AANFLL GEMKNP 
               
               
                   
               
               
                 22 
                 The amino acid sequence of SEQ ID 
                 MAMVQRQGHDPSSPQEQEDGPSSFLSDDALYCEEGRFEE 
               
               
                   
                 282. The conserved cyclin N- and 
                 DDGGGGGQVDGIPLFPSQPADRQQDSPWADEDGEEKEEE 
               
               
                   
                 C-terminal family domains are 
                 EAELQSLFSKERGARPELAKDDGGAVAARREAV EWMLMV   
               
               
                   
                 underlined. 
                 
                   RGVYGFSALTAVLAVDYLDRFLAGFRLQRDNRPWMTQLV 
                 
               
               
                   
                   
                 
                   AVACLALAAKVEETDVPLLVELQEVGDARYVFEAKTVQR 
                 
               
               
                   
                   
                   MELLVLS TLGWEMHP VTPLSFVHHVARRLGASPHHGEFT   
               
               
                   
                   
                 
                   HWAFLRRCERLLVAAVSDARSLKHLPSVLAAAAMLRVIE 
                 
               
               
                   
                   
                 
                   EVEPFRSSEYKAQLLSALHMSQEMVEDCCRFILGIAETA 
                 
               
               
                   
                   
                 
                   GDAVTSSLDSFLKRKRRCGHLSPRSPSGVIDASFSCDDE 
                 
               
               
                   
                   
                   SNDSW ATDPPSDPDDNDDLNPLPKKSRSSSPSSSPSSVP 
               
               
                   
                   
                 DKVLDLPFMNRIFEGIVNGSPI 
               
               
                   
               
               
                 23 
                 The amino acid sequence of SEQ ID 
                 MEASYQPHHHGHLRQHDPSSSQQEEQVPFDALYCSEEHW 
               
               
                   
                 283. The conserved cyclin and 
                 GEEDEEEGLASDGLLSEERDHRLLSPRALLDQDLLWED E   
               
               
                   
                 cyclin C-terminal domains are 
                 
                   ELASLFSKEEPGGMRLNLENDPSLADARREAVEWIMRVH 
                 
               
               
                   
                 underlined. 
                 
                   AHYAFSALTALLAVNYWDRFTCSFALQEDKPWMTQLSAV 
                 
               
               
                   
                   
                 
                   ACLSLAAKVEETQVPLLIDFQVEDSSPVFEAKNIQRMEL 
                 
               
               
                   
                   
                   LVLSSLEWKMN P VTPLSFLDYMTRRLGLTGHLCWEFLRR   
               
               
                   
                   
                 
                   CENVLLSVISDCRFTCYLPSVIAASTMLHVINGLKPRLD 
                 
               
               
                   
                   
                 
                   VEDQTQLLGILAMGMDKIDACYKLIDDDHALRSQRYSHN 
                 
               
               
                   
                   
                   KRKFGSVPGSPRGVMELCFSSDGSNDSW SVAASVSSSPE 
               
               
                   
                   
                 PHSKKSRAGEEAEDRLLRGLEGEEDDPASADIFSFPH 
               
               
                   
               
               
                 24 
                 The amino acid sequence of SEQ ID 
                 MALQEEDTRRHYPTAPPFSPDGLYCEDETFGEDLADNAC 
               
               
                   
                 284. The conserved cyclin and 
                 EYAGGGARDGLCEIKDPTLPPSLLGQDLFWED GELASLV   
               
               
                   
                 cyclin C-terminal domains are 
                 
                   SRETGTHPCWDELISDGSVALARKDAVGWILRVHGHYGF 
                 
               
               
                   
                 underlined. 
                 
                   RPLTAMLAVNYLDRFFLSRSYQRDRPWISQLVAVACLSV 
                 
               
               
                   
                   
                 
                   AAKVEETQVPILLDLQVANAKFVFESRTIQRMELLLMST 
                 
               
               
                   
                   
                   LDWRMN S VTPISFFDHILRRFGLTTNLHRQFFWMCERLL   
               
               
                   
                   
                 
                   LSVVADVRLASFLPSVVATAAMLYVNKEIEPCICSEFLD 
                 
               
               
                   
                   
                 
                   QLLSLLKINEDRVNECYELILELSIDHPEILNYKHKRKR 
                 
               
               
                   
                   
                   GSVPSSPSGVIDTSFSCDSSNDSW GVASSVSSSLEPRFK 
               
               
                   
                   
                 RSRFQDQQMGLPSVNVSSMGVLNSSY 
               
               
                   
               
               
                 25 
                 The amino acid sequence of SEQ ID 
                 
                   MGQIQ YSEKYFDDTYEYRHVVLPP DVAKLLPKNRLLSEN 
                 
               
               
                   
                 285. The conserved cyclin- 
                   EWRAIGVQQSRGWVHYAIHRPEPHIMLFRRPLN YQQQQE 
               
               
                   
                 dependent kinases regulatory 
                 NQAQQNMLAK 
               
               
                   
                 subunit domain is underlined and 
               
               
                   
                 the cyclin-dependent kinases 
               
               
                   
                 regulatory subunits signature 1 is 
               
               
                   
                 in bold. 
               
               
                   
               
               
                 26 
                 The amino acid sequence of SEQ ID 
                 MGSIDPPKAEQNGTAAAAVADPGQKPGAGDAMPPPPPVK 
               
               
                   
                 286. The conserved chromo domain 
                 HSNGTAAEPDVATKRRRMSVLPLEVGTRVMCRWRDG KYH   
               
               
                   
                 is underlined and the MOZ/SAS-like 
                 
                   PVKVIERRKLNPGDPNDYEYYVHYTEFNRRLDEWVKLEQ 
                 
               
               
                   
                 protein domain is in bold/italics. 
                   LDLNSVETVVDEKVEDKV TGLKMTRHQKRKIDETHVEGH 
               
               
                   
                   
                 EELDAASLREHEEFTKVKNIATIELGRYEIETWYFSPFP 
               
               
                   
                   
                 PEYNDCSKLYFCEFCLNFMKRKEQLQRHMKKCD   
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                      PKVLDRHLKAAGRG 
               
               
                   
                   
                 GLEVDVSKLIWTPYREQG 
               
               
                   
               
               
                 27 
                 The amino acid sequence of SEQ ID 
                 MDTGGNSLPSGPDGVK RKVCYFYDPEVGNYYLLQHMQVL   
               
               
                   
                 292. The conserved histone 
                 
                   KPVPARDRDLCRFHADDYVAFLRSITPETQQDQLRQLKR 
                 
               
               
                   
                 deacetylase family domain is 
                 
                   FNVGEDCPVFDGLHSFCQTYAGGSVGGAVKLNHGLCDIA 
                 
               
               
                   
                 underlined. 
                 
                   INWAGGLHHAKKCEASGFCYVNDIVLGILELLKQHERVL 
                 
               
               
                   
                   
                 
                   YVDIDIHHGDGVEEAFYTTDRVMTVSFHKFGDYFPGTGD 
                 
               
               
                   
                   
                 
                   IRDIGYGKGKYYSLNVPLDDGIDDESYHSLFKPIIGKVM 
                 
               
               
                   
                   
                 
                   EVFKPGAVVLQCGADSLSGDRLGCFNLSIKGHAECVRYM 
                 
               
               
                   
                   
                   RSFNVPVLLLGGGGYTIRNVARCWCYETGVALG LEVDDK 
               
               
                   
                   
                 MPQHEYYEYFGPDYTLHVAPSNMENKNSRQLLEEIRSKL 
               
               
                   
                   
                 LENLSKLQHAPSVPFQERPPDTELPEADEDQEDPDERWD 
               
               
                   
                   
                 PDSDMDVDEDRKPLPSRVKRELIVEPEVKDQDSQKASID 
               
               
                   
                   
                 HGRGLDTTQEDNASIKVSDMNSMITDEQSVKMEQDNVNK 
               
               
                   
                   
                 PSEQIFPK 
               
               
                   
               
               
                 28 
                 The amino acid sequence of SEQ ID 
                 MDTGGNSLPSGPDGVK RKVCYFYDPEVGNYYYGQGHPMK   
               
               
                   
                 293. The conserved histone 
                 
                   PHRIRMTHALLAHYGLLQHMQVLKPVPARDRDLCRFHAD 
                 
               
               
                   
                 deacetylase family domain is 
                 
                   DYVAFLRSITPETQQDQLRQLKRFNVGEDCPVFDGLHSF 
                 
               
               
                   
                 underlined. 
                 
                   CQTYAGGSVGGAVKLNHGLCDIAINWAGGLHHAKKCEAS 
                 
               
               
                   
                   
                 
                   GFCYVNDIVLGILELLKQHERVLYVDIDIHHGDGVEEAF 
                 
               
               
                   
                   
                 
                   YTTDRVMTVSFHKFGDYFPGTGDIRDIGYGKGKYYSLNV 
                 
               
               
                   
                   
                 
                   PLDDGIDDESYHSLFKPIIGKVMEVFKPGAVVLQCGADS 
                 
               
               
                   
                   
                 
                   LSGDRLGCFNLSIKGHAECVRYMRSFNVPVLLLGGGGYT 
                 
               
               
                   
                   
                   IRNVARCWCYETGVALG LEVDDKMPQHEYYEYFGPDYTL 
               
               
                   
                   
                 HVAPSNMENKNSRQLLEDIRSKLLENLSKLQHAPSVPFQ 
               
               
                   
                   
                 ERPPDTELPEADEDQEDPDERWDPDSDMDVDEDRKPLPS 
               
               
                   
                   
                 RVKRELIVEPEVKDQDSQKASIDHGRGLDTTQEDNASIK 
               
               
                   
                   
                 VSDMNSMITDEQSVKMEQDNVNKPSEQIFPK 
               
               
                   
               
               
                 29 
                 The amino acid sequence of SEQ ID 
                 MRPK DRISYFYDGDVGSVYFGPNHPMKPHRLCMTHHLVL   
               
               
                   
                 294. The conserved histone 
                 
                   SYELHTKMEIYRPHKAYPAELAQFHSPDYVEFLHRITPD 
                 
               
               
                   
                 deacetylase domain is underlined. 
                 
                   TQHLFPNDLAKYNLGEDCPVFENLFEFCQIYAGGTIDAA 
                 
               
               
                   
                   
                 
                   RRLNNQLCDIAINWAGGLHHAKKCEASGFCYINDLVLGI 
                 
               
               
                   
                   
                 
                   LELLKYHARVLYIDIDVHHGDGVEEAFYFTDRVMTVSFH 
                 
               
               
                   
                   
                 
                   KFGDMFFPGTGDVKEIGGKEGKFYAINVPLKDGIDDTSF 
                 
               
               
                   
                   
                 
                   TRLFKAIISKVVETYQPGAIVLQCGADSLAGDRLGCFNL 
                 
               
               
                   
                   
                 
                   SIDGHSECVRFVKKFNLPLLVTGGGGYTKENVARCWVVE 
                 
               
               
                   
                   
                   TGVLLD TELPNEIPENEYFKYFAPDYSLKIPRGNIVLEN 
               
               
                   
                   
                 LNSKSYLSAIKVQVLENLRNIQHAPSVQMQEVPPDFYIP 
               
               
                   
                   
                 DFDEDEQNPDERMDQHTQDKQIQRDDEYYDGDNDNDHNM 
               
               
                   
                   
                 DD 
               
               
                   
               
               
                 30 
                 The amino acid sequence of SEQ ID 
                 MTVAEDFHVNNRSKMVSQATPESRLTGGEDDNSLHNQVD 
               
               
                   
                 295. The conserved histone 
                 ELLCQELPERQVILEFEGTRPKPYFSDHNGGENSALGVR 
               
               
                   
                 deacetylase family domain is 
                 ATEDDLNSDVEAEEKQKEMTLEDMYKNDGTLYDDDEDDS 
               
               
                   
                 underlined and the Zinc finger 
                 DWEPVKRQVELMR WFCTNCTMVNVEDVFLCDIC GEHRDS 
               
               
                   
                 RanBP2-type profile is in bold. 
                 GILRHGFYASPFMQDVGAPSVEAEVQESREDHARSSPPS 
               
               
                   
                   
                 
                   SSTVVGFDEKMLLHSEVEMKSHPHPERADRLQAIAASLA 
                 
               
               
                   
                   
                 
                   TAGIFPGRCRSLPVREITKEELQMVHSSEHVDAVEMTSH 
                 
               
               
                   
                   
                 
                   MFSSYFTPDTYANEHSARAARIAAGLCADLASTIISGRS 
                 
               
               
                   
                   
                 
                   KNGFALVRPPGHHAGIKHAMGFCLHNNAAVAALAAQGAG 
                 
               
               
                   
                   
                 
                   AKKVLIVDWDVHHGNGTQEIFDGNKSVLYISLHRHEGGN 
                 
               
               
                   
                   
                 
                   FYPGTGAAHEVGTMGAEGYCVNIPWSRRGVGDNDYVFAF 
                 
               
               
                   
                   
                 
                   HHIVLPIASAFAPDFTIISAGFDAARGDPLGCCDVTPAG 
                 
               
               
                   
                   
                 
                   YAQMTHMLSALSGGKLLVILEGGYNLRSISSSAVAVIKV 
                 
               
               
                   
                   
                   LLG DSPISEIADAVPSKAGLRTVLEVLKIQRSYWPSLES 
               
               
                   
                   
                 IFWELQSQWGMFLVDNRRKQIRKRRRVLVPIWWKWGRKS 
               
               
                   
                   
                 VLYHLLNGHLHVKTKR 
               
               
                   
               
               
                 31 
                 The amino acid sequence of SEQ ID 
                 
                   MAAAPSSPPTNRVDVFWHDGMLSHDTGRGVFDTGSDPGF 
                 
               
               
                   
                 296. The conserved histone 
                 
                   LDVLEKHPENPDRVRNMVSILKRGPISPFISWHTATPAL 
                 
               
               
                   
                 deacetylase family domain is 
                 
                   ISQLLSFHSPEYINELVEADKNGGKVLCAGTFLNPGSWD 
                 
               
               
                   
                 underlined. 
                 
                   AALLAAGNTLSAMKYVLDGKGKIAYALVRPPGHHAQPSQ 
                 
               
               
                   
                   
                 
                   ADGYCFLNNAGLAVRLALDSGCKRVVVVDIDVHYGNGTA 
                 
               
               
                   
                   
                 
                   EGFYQSSDVLTISLHMNHGSWGPSHPQSGSVDELGEDEG 
                 
               
               
                   
                   
                   YGYNMNIPLPNGTGDRGYEYAVTELVVPAVESFKPEMV V 
               
               
                   
                   
                 LVVGQDSSAFDPNGRQCLTMDGYRAIGRTIRGLADRHSG 
               
               
                   
                   
                 GRILIVQEGGYHVTYSAYCLHATVEGILDLPDPLLADPI 
               
               
                   
                   
                 AYYPEDEAFPVKVVDSIKRYLVDKVPFLKEH 
               
               
                   
               
               
                 32 
                 The amino acid sequence of SEQ ID 
                 MVESSGGASLPSVGQDARK RRVSYFYEPTIGDYYYGQGH   
               
               
                   
                 297. The conserved histone 
                 
                   PMKPHRIRMAHNLIVHYYLHRRMEISRPFPAATTDIRRF 
                 
               
               
                   
                 deacetylase family domain is 
                 
                   HSEDYVTFISSVTPETVSDPAFSRQLKRFNVGEDCPVFD 
                 
               
               
                   
                 underlined. 
                 
                   GIFGFCQASAGGSMGAAVKLNRGDSDIALNWAGGLHHAK 
                 
               
               
                   
                   
                 
                   KSEASGFCYVNDIVLGILELLKVHKRVLYVDIDVHHGDG 
                 
               
               
                   
                   
                 
                   VEEAFYTTDRVMTVSFHKFGDFFPGSGHIKDTGAGPGKN 
                 
               
               
                   
                   
                 
                   YALNVPLNDGIDDESFRGMFRPIIQKVMEVYQPDAVVLQ 
                 
               
               
                   
                   
                 
                   CGADSLSGDRLGCFNLSVKGHADCLRFLRSFNVPLMVLG 
                 
               
               
                   
                   
                   GGGYTMRNVARCWCYETAVAVG VEPENDLPYNEYYEYFG 
               
               
                   
                   
                 PDYTLHVEPCSMENLNAPKDLERIRNMLLEQLSRIPHAP 
               
               
                   
                   
                 SVPFQMTPPITQEPEEAEEDMDERPKPRIWNGEDYESDA 
               
               
                   
                   
                 EEDKSQHRSSNADALHDENVEMRDSVGENSGDKTREDRS 
               
               
                   
                   
                 PS 
               
               
                   
               
               
                 33 
                 The amino acid sequence of SEQ ID 
                 MAAIISCHHYHSCCSSLIASKWVGARIPTSCFGRSSTQS 
               
               
                   
                 299. The conserved cyclophilin- 
                 NNAASVRQFVTRCSSSPSSRGQWQPHQNGEKGRSFSLRE 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 CAISIALAVGLVTGVPSLDMSTGNAYAASPALPDLSVLI 
               
               
                   
                 isomerase family domain is 
                 SGPPIKDPEALLRYALPINNKAIREVQKPLEDITDSLKV 
               
               
                   
                 underlined. 
                 AGLRALDSVERNVRQASRVLKQGKNLIVSGLAESKKDHG 
               
               
                   
                   
                 VELLDKLEAGMDELQQIVEDGNRDAVAGKQRELLNYVGG 
               
               
                   
                   
                 VEEDMVDGFPYEVPEEYKNMPLLKG RAAVDMKVKVKDNP   
               
               
                   
                   
                 
                   NLEECVFRIVLDGYNAPVTAGNFVDLVERHFYDGMEIQR 
                 
               
               
                   
                   
                 
                   ADGFVVQTGDPEGPAESFIDPSTEKPRTIPLEIMVDGEK 
                 
               
               
                   
                   
                 
                   APVYGATLEELGLYKAQTKLPFNAFGTMAMARDEFEDNS 
                 
               
               
                   
                   
                 
                   ASSQIFWLLKESELTPSNANILDGRYAVFGYVTENQDFL 
                 
               
               
                   
                   
                   ADLKVGDVIESVQVVS GLDNLANPSYKIAG 
               
               
                   
               
               
                 34 
                 The amino acid sequence of SEQ ID 
                 MAGEDFDIPPADEMNEDFDLPDDDDDAPVMKAGDEKEIG 
               
               
                   
                 300. The conserved FKBP-type 
                 KQGLKKKLVKE GDAWETPDNGDEVE VHYTGTLLDGTQFD     
               
               
                   
                 peptidylprolyl isomerase domains 
                 
                     SS RDRGTPFKFTLGQGQ 
                   
                 
               
               
                   
                 are underlined. The FKBP-type 
                     EAGSPPTIPPNATLQFDVELL SWTSVKDICKD 
               
               
                   
                 peptidyl-prolyl cis-trans 
                 GGIFKKILVE GEKWENPKDLDEVLVKYEFQLEDGTTIAR   
               
               
                   
                 isomerase signature 1 is in bold 
                 
                   SDGVEFTVKEGHFCPAVAKAVKTMKKGEKVLLTVKPQYG 
                 
               
               
                   
                 and the FKBP-type peptidyl-prolyl 
                   FGEKGKPASGDEGAVPPNATLQITLELV SWKTVSEVTDD 
               
               
                   
                 cis-trans isomerase signature 2 is 
                 KKVIKKILKE GEGYERPNEGAVVEVKLIGKLQDGTVFVK   
               
               
                   
                 in bold/italics. 
                 
                   KGHDDCEELFKFKIDEEQ 
                   
                 
               
               
                   
                   
                     SSESKQDLAVVPPSSTVYYEVELV SFVKDKE 
               
               
                   
                   
                 SWDMNTEEKIEAAGKKKEEGNVIFKAGKYAKASKRYEKA 
               
               
                   
                   
                 VKYIEYDTSFSEDEKKQAKALKVACNLNDAACKLKLKDY 
               
               
                   
                   
                 NQAEKLCTKVLELDSRNVKALYRRAQAYIELSDLDLAEF 
               
               
                   
                   
                 DIKKALEIDPHNRDVKLEYKVLKEKVKEFNKKDAKFYGN 
               
               
                   
                   
                 MFAKMSKLEPVEKTAAKEPEPMSIDSKA 
               
               
                   
               
               
                 35 
                 The amino acid sequence of SEQ ID 
                 MSTVYVLEPPTKG KVVLNTTHGPLDVELWPKEAPKAVRN   
               
               
                   
                 301. The conserved cyclophilin- 
                 
                   FVQLCLEGY YDNTIFHRIIKDFLVQGGD PTGSGTGGESI 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   YGDAFSDEFHSRLRFKHRGLVACANAGSPHSNGSQFFIT 
                 
               
               
                   
                 isomerase family domain is 
                 
                   LDRCDWLDRKNTIFGKITGDSIYNLSGLAEVETDKSDRP 
                 
               
               
                   
                 underlined and the cyclophilin- 
                   LDPPPKIISVEVLW NPFEDIVPRAPVRSLVPTVPDVQNK 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 EPKKKAVKKLNLLSFGEEAEEEEKALVVVKQKIKSSHDV 
               
               
                   
                 isomerase signature is in bold. 
                 LDDPRLLKEHIPSKQVDSYDSKTARDVQSVREALSSKKQ 
               
               
                   
                   
                 ELQKESGAEFSNSFREIADDEDDDDDDASFDARMRRQIL 
               
               
                   
                   
                 QKRKELGDLPPKPKPKSRDGISARKERETSISRDKDDDD 
               
               
                   
                   
                 DDDQPRVEKLSLKKKGIGSEARGERMANADADLQLLNDA 
               
               
                   
                   
                 ERGRQLQKQKKHRLRGREDEVLTKLETFKASVFGKPLAS 
               
               
                   
                   
                 SAKVGDGDGDLSDWRSVKLKFAPEPGKDRMTRNEDPNDY 
               
               
                   
                   
                 VVVDPLLEKGKEKFNRMQAKEKRRGREWAGKSLT 
               
               
                   
               
               
                 36 
                 The amino acid sequence of SEQ ID 
                 MASAISMHSSGLLLLQGTNGKDVTEMGKAPASSRVANMQ 
               
               
                   
                 302. The conserved cyclophilin- 
                 QRKYGATCCVARGLTSRSHYASSLAFKQFSKTPSIKYDR 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 MVEIKAMATDLGLQAKVTN KCFFDVEIGGEPAGRIVIGL   
               
               
                   
                 isomerase family domain is 
                 
                   FGDDVPKTVENFRALCTGEKGFG YKGCSFHRIIKDFMIQ   
                 
               
               
                   
                 underlined and the cyclophilin- 
                 
                     GG DFTRGNGTGGKSIYGSTFEDENFALKHVGPGVLSMAN 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   AGPSTNGSQFFICTVKTPWLDNRHVVFGQVVDGMDVVQK 
                 
               
               
                   
                 isomerase signature is in bold. 
                   LESQETSRSDVPRQPCRIVNCGELP LDG 
               
               
                   
               
               
                 37 
                 The amino acid sequence of SEQ ID 
                 MAASFTALSNVGSLSSPRNGSEIRRFRPSCNVAASVRPP 
               
               
                   
                 303. The conserved cyclophilin- 
                 PLKAGLSASSSSSFSGSLRLIPLSSSPQRKSRPCSVRAS 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 AEAAAAQSKVTN KVYLDISIGNPVGKLVGRIVIGLYGDD   
               
               
                   
                 isomerase signature is underlined. 
                 
                   VPQTAENFRALCTGEKGFGYKGSTVHRVIKDFMIQGGDF 
                 
               
               
                   
                   
                 
                   DKGNGTGGKSIYGRTFKDENFKLSHVGPGVVSMANAGPN 
                 
               
               
                   
                   
                 
                   TNGSQFFICTVKTPWLDQRHVVFGQVLEGMDIVRLIESQ 
                 
               
               
                   
                   
                   ETDRGDRPRKRVVVSDCGELP VV 
               
               
                   
               
               
                 38 
                 The amino acid sequence of SEQ ID 
                 MAEAIDLTGDGGVMKTIVRRAK PDAVSPSETLPLVDVRY   
               
               
                   
                 304. The conserved FKBP-type 
                 
                   EGVLAETGEVFDSTHEDNTLFSFEIGKGS VISAWDTALR   
                 
               
               
                   
                 peptidyl-prolyl cis-trans 
                 
                     TMKVGEVAKITCKPEYAYG STGSPPDIPPDATLIFEVEL 
                 
               
               
                   
                 isomerase signature is underlined 
                   V ACKPCKGFSVTSVTEDKARLEELKKQREIAAATKEEEK 
               
               
                   
                 and the FKBP-type peptidyl-prolyl 
                 KRREEAKAAAAARVQAKLDAKKGHGKGKGKAK 
               
               
                   
                 cis-trans isomerase signature 2 is 
               
               
                   
                 in bold. 
               
               
                   
               
               
                 39 
                 The amino acid sequence of SEQ ID 
                 MGNP KVFFDMSIGGQPAGRIVMELYADVVPRTAENFRAL   
               
               
                   
                 305. The conserved cyclophilin- 
                 
                   CTGEKGAGRSGKPLH YKGSSFHRVIPGFMCQGG DFTAGN 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   GTGGESIYGSKFADENFVKKHTGPGVLSMANAGPGTNGS 
                 
               
               
                   
                 isomerase family domain is 
                 1 QFFVCTAKTEWLDGKHVVFGQIVDGMDVVKAIEKVGSSS   
               
               
                   
                 underlined and the cyclophilin- 
                 
                   GRTSKPVVVADCGQLS 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
               
               
                   
                 isomerase signature is in bold. 
               
               
                   
               
               
                 40 
                 The amino acid sequence of SEQ ID 
                 MPNP KVFFDMTIGGAAAGRVVMELYADTTPRTAENFRAL   
               
               
                   
                 306. The conserved cyclophilin- 
                 
                   CTGEKGVGRSKKPLH YKGSKFHRVIPSFMCQGG DFTAGN 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   GTGGESIYGVKFADENFIKKHTGPGILSMANAGPGTNGS 
                 
               
               
                   
                 isomerase signature is underlined 
                 
                   QFFICTTKTEWLDGKHVVFGKVVEGMEVVKAIEKVGSSS 
                 
               
               
                   
                 and the cyclophilin-type peptidyl- 
                 
                   GRTSKPVVVADCGQLP 
                 
               
               
                   
                 prolyl cis-trans isomerase 
               
               
                   
                 signature is in bold. 
               
               
                   
               
               
                 41 
                 The amino acid sequence of SEQ ID 
                 MAEAIDLTGDGGVMKTIVRRAKPDAVS PSETLPLVDVRY   
               
               
                   
                 307. The conserved FKBP-type 
                 
                   EGVLAETGEVFDSTHEDNTLFSFEIGKGSV ISAWDTALR   
                 
               
               
                   
                 peptidyl-prolyl cis-trans 
                 
                     TMKVGEVAKITCKPEYAYG STGSPPDIPPDATLIFEVEL 
                 
               
               
                   
                 isomerase signature is underlined 
                   V ACKPCKGFSVTSVTEDKARLEELKKQREIAAATKEEEK 
               
               
                   
                 and the FKBP-type peptidyl-prolyl 
                 KRREEAKAAAAARVQAKLDAKKGHGKGKGKAK 
               
               
                   
                 cis-trans isomerase signature 2 is 
               
               
                   
                 in bold. 
               
               
                   
               
               
                 42 
                 The amino acid sequence of SEQ ID 
                 MATARSFFLCALLLLATLYLAQAKKSEDLKEVTH KVYFD   
               
               
                   
                 308. The conserved cyclophilin- 
                 
                   VEIAGKPAGRIVMGLYGKAVPKTAENFRALCTGEKGTGK 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   SGKPLH YKGSSFHRIIPSFMLQGG DFTLGDGRGGESIYG 
                 
               
               
                   
                 isomerase signature is underlined 
                 
                   EKFADENFKLKHTGPGLLSMANAGPDTNGSQFFITTVTT 
                 
               
               
                   
                 and the cyclophilin-type peptidyl- 
                 
                   SWLDGRHVVFGKVLSGMDVVYKVEAEGRQSGTPKSKVVI 
                 
               
               
                   
                 prolyl cis-trans isomerase 
                   ADSGELP L 
               
               
                   
                 signature is in bold. 
               
               
                   
               
               
                 43 
                 The amino acid sequence of SEQ ID 
                 MMRREISVLLQPRFVLAFLALAVLLLVFAFPFSRQRGDQ 
               
               
                   
                 309. The conserved cyclophilin- 
                 VEEEPEITH RVYLDVDIDGQHLGRIVIGLYGEVVPRTVE   
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   NFRALCTGEKGKSANGKKLH YKGTPFHRIISGFMIQGG D 
                 
               
               
                   
                 isomerase family domain is 
                 
                   VIYGDGKGYESIYGGTFADENFRIKHSHAGIISMVNSGP 
                 
               
               
                   
                 underlined and the cyclophilin- 
                 
                   DSNGSQFFITTVKASWLDGEHVVFGRVIQGMDTVYAIEG 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                   GAGTYNGKPRKKVIIADSGEIP KSKWDEER 
               
               
                   
                 isomerase signature is in bold. 
               
               
                   
               
               
                 44 
                 The amino acid sequence of SEQ ID 
                 MWATAEGGPPE VTLETSMGSFTVELYFKHAPRTSRNFIE   
               
               
                   
                 310. The conserved cyclophilin- 
                 
                   LSRRGY YDNVKFHRIIKDFIVQGG DPTGTGRGGESIYGK 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   KFEDEIKPELKHTGAGILSMANAGPNTNGSQFFITLAPC 
                 
               
               
                   
                 isomerase family domain is 
                 
                   PSLDGKHTIFGRVCRGMEIIKRLGSVQTDNNDRPIHDVK 
                 
               
               
                   
                 underlined and the cyclophilin- 
                 
                   ILRTSVKD 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
               
               
                   
                 isomerase signature is in bold. 
               
               
                   
               
               
                 45 
                 The amino acid sequence of SEQ ID 
                 MSNP KVFFDILIGKMKAGRVVMELFADVTPKTAENFRAL   
               
               
                   
                 311. The conserved cyclophilin- 
                 
                   CTGEKGIGRSGKPLH YKGSTFHRIIPNFMCQGG DFTRGN 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   GTGGESIYGMKFADENFKIKHTGLGVLSMANAGPDTNGS 
                 
               
               
                   
                 isomerase family domain is 
                 
                   QFFICTEKTPWLDGKHVVFGKVIDGYNVVKEMESVGSDS 
                 
               
               
                   
                 underlined and the cyclophilin- 
                   GSTRETVAIEDCGQLS EN 
               
               
                   
                 type peptidyl-prolyl cis-trans 
               
               
                   
                 isomerase signature is in bold. 
               
               
                   
               
               
                 46 
                 The amino acid sequence of SEQ ID 
                 MDDDFEFPASSNVENDDDDGMDMDDMGGDVPEEEDPVAS 
               
               
                   
                 312. The conserved FKBP-type 
                 PAVLKVGEEREIGKAGFKKKLVKE GEGWETPSSGDEVE V     
               
               
                   
                 peptidylprolyl isomerase domains 
                 
                     HYTGTLLDGTKFDSS RDRGTPFKFKLGRGQ 
                   
                 
               
               
                   
                 are underlined. The FKBP-type 
                 
                   
                   ESGSPPTIPPNATLQFDVE 
                 
               
               
                   
                 peptidyl-prolyl cis-trans 
                   LL SWSSVKDICKDGGILKKVLVE GEKWDNPKDLDEVFVK   
               
               
                   
                 isomerase signature 1 is in bold 
                 
                   YEASLEDGTLISKSDGVEFTVGDGYFCAALAKAVKTMKK 
                 
               
               
                   
                 and the FKBP-type peptidyl-prolyl 
                 
                   GEKVLLTVMPQYAFGETGRPASGDEAAVPPDASLQIMLE 
                 
               
               
                   
                 cis-trans isomerase signature 2 is 
                   LV SWKTVSDVTKDKKVLKKTLKE GEGYERPNDGAAVQVR   
               
               
                   
                 in bold/italics. The TPR repeat 
                 
                   LCGKLQDGTVFVKKDDEEPFEFKIDEEQ 
                   
                 
               
               
                   
                 is in italics. 
                 
                   
                   PTESQQDLAVVPANSTVYYEV 
                 
               
               
                   
                   
                   ELL SFVKEKESWEMNNQEKIEAAARKKEEGNAAFKAGKY 
               
               
                   
                   
                 VRASKRYEKAVRFIEYDSSFSDEEKQQAKTLKNTCNLND 
               
               
                   
                   
                 AACKLKLKDFKEAEKLCTKVLEGDGKNVKALYRRAQAYI 
               
               
                   
                   
                 QLVDLDLAEQDIKKALEIDPNNRDVKLEYKILKEKVREY 
               
               
                   
                   
                 NKRDAQFYGNMFAKMNKLEHSRTAGMGAKHEAAPMTIDS 
               
               
                   
                   
                 KA 
               
               
                   
               
               
                 47 
                 The amino acid sequence of SEQ ID 
                 MAKP RCFMDISIGGELEGRIVGELYTDVAPKTAENFRAL   
               
               
                   
                 313. The conserved cyclophilin- 
                 
                   CTGEKGIGPHTGAPLH YKGVRFHRVIKGFMVQGG DISAG 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   DGTGGESIYGLKFEDENFDLKHERKGMLSMANSGPNTNG 
                 
               
               
                   
                 isomerase family domain is 
                 
                   SQFFITTTRTSHLDGKHVVFGRVVKGMGVVRSVEHVTTA 
                 
               
               
                   
                 underlined and the cyclophilin- 
                   AGDCPTVDVVIADCGEIP AGADDGIRNFFKDGDTYPDWP 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 ADLDESPAELSWWMDAVDSIKAFGNGSYKKQDYKMALRK 
               
               
                   
                 isomerase signature is in bold. 
                 YRKALRYLDICWEKEGIDEVESSSLRKTKSQIFTNSSAC 
               
               
                   
                 The TPR repeat is in bold/italics. 
                 KLKLCDLKGALLDAEFAVRDGENN   
               
               
                   
                   
                    GIKKELNAAKKKIFERREQ 
               
               
                   
                   
                 EKRAYRKMFL 
               
               
                   
               
               
                 48 
                 The amino acid sequence of SEQ ID 
                 MTKRKNP LVFLDVSIDGDPVERIVIELFADTVPRTAENF   
               
               
                   
                 314. The conserved cyclophilin- 
                 
                   RSLCTGEKGVGKTTGKPLHYKGSYFHRIIK GFMAQGG DF 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   SNGNGTGGESIYGGKFADENFKLAHDGPGLLSMANGGPN 
                 
               
               
                   
                 isomerase signature is underlined 
                 
                   TNGSQFFIIFKRQPHLDGKHVVFGKVMRGMEVVKKIEQV 
                 
               
               
                   
                 and the cyclophilin-type peptidyl- 
                   GSANGKPLQPVKIVDCGETS ETGTQDAVVEEKSKSATLK 
               
               
                   
                 prolyl cis-trans isomerase 
                 AKKKRSARDSSSESRGKRRQRKSRKERTRKRRRYSSSDS 
               
               
                   
                 signature is in bold. 
                 YSSESSDSDSESYSSDTESESKSHSESSVSDSSSSDGRR 
               
               
                   
                   
                 RKRKSTKREKLRRQRGKDSRGEQKSARYDKKSRHKSADS 
               
               
                   
                   
                 SSDSESESSSRSRSRDDKKKSSRRESARSVSKLKDAEAN 
               
               
                   
                   
                 SPENLESPRDREIKKVEDNSSHEEGEFSPKNDVQHNGHG 
               
               
                   
                   
                 TDAKFGKYDDQRPRSDGSKKSSGSMRDSPKRLANSVPQG 
               
               
                   
                   
                 SPSSSPAHKASEPSSSIRARNPSRSPAPDGNSKRIRKGR 
               
               
                   
                   
                 GFTERFSYARRYRTPSPEDVTYRPYHYGRRNFHDRRNDR 
               
               
                   
                   
                 YSNYRSYSERSPHRRYRSPPRGRSPPRYQRRRSRSRSVS 
               
               
                   
                   
                 RSPGGNKGRYRGRDQSRSRSRSRSRSPRRGSSPANKQLP 
               
               
                   
                   
                 LSERLKSRLGTRVDEHSPRRRRSSSRSHDSSRSRSPDEV 
               
               
                   
                   
                 PDKHEGKAAPVSPARSRSSSPSGRGLVSYGDASPDSGIN 
               
               
                   
               
               
                 49 
                 The amino acid sequence of SEQ ID 
                 MS VLLVTSLGDIVVDLHADRCPLTCKNFLKLCRIKYYNG   
               
               
                   
                 315. The conserved cyclophilin- 
                 
                   CVFHTVQKDFTAQTGDPTGTGTGGDSVYKFLYGDQARFF 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   MDEIHLDLKHSKTGTVAMASGGENLNASQFYFTLRDDLD 
                 
               
               
                   
                 isomerase signature is underlined. 
                 
                   YLDGKHTVFGEVAEGLETLTRINEAYVDEKGRPYKNIRI 
                 
               
               
                   
                 The CCHC type zinc finger is in 
                   RHTYILD DPFDDPPQLAELIPDASPEGKPKDEVVDDVRL 
               
               
                   
                 bold and the RNA-binding region 
                 EDDWVPLDEQLGPAQLEEAIRAKEAHSRAVVLESIGDIP 
               
               
                   
                 RNP-1 (RNA recognition motif) is 
                 DAEIKPPDNV     
               
               
                   
                 in bold/italics. 
                 
                   
                   
                 
               
               
                   
                   
                    DFSQSVAKLWSQFKRKDSQAAKG KGCFKCGAPDHM   
               
               
                   
                   
                   ARECPG SSTRQPLSKYILKEDNAQRGGDDSRYEMVFDED 
               
               
                   
                   
                 APESPSHGKKRRGRDDRDDRHKMSRQSVEETKFNDREGG 
               
               
                   
                   
                 HSVDKHRQSERSKHREDEMSRDSKASEAGRRRIDRDFPE 
               
               
                   
                   
                 EERDGEKYTESHRDRDGKRGDYRDYRKGRADVQTHGDRR 
               
               
                   
                   
                 GDENYRRKSAAYDDGHEGAGAARRKDSNDDHHAYRRGYG 
               
               
                   
                   
                 DSRKGTRDEDDDGRGRRDDPSYRRSSGHKDSSNGGREEQ 
               
               
                   
                   
                 KYRSGETDGKSHPERSHRGDRRR 
               
               
                   
               
               
                 50 
                 The amino acid sequence of SEQ ID 
                 MRPFNGGSSIACLVLVIAAGALAESQGPHLGSA RVVFQT   
               
               
                   
                 316. The conserved cyclophilin- 
                 
                   NYGDIEFGFFPGVAPRTVDHIFKLVRLGCYNTNHFFRVD 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   KGFVAQVADVANGRTAPMNDEQRTEAEKTIVGEFSNVKH 
                 
               
               
                   
                 isomerase signature is underlined. 
                 
                   VRGILSMGRYDDPDSAQSSFSILLGDAPHLDGKYAIFGR 
                 
               
               
                   
                   
                   VTKGDETLKKLEQLPTRREGMFVMPTERITILSSYYYD T 
               
               
                   
                   
                 GAESCEEENSTLRRRLAASAVEVERQRMKCFP 
               
               
                   
               
               
                 51 
                 The amino acid sequence of SEQ ID 
                 MPNP KVFFDMQVGGAPAGRIVMELYADVVPKTAENFRAL   
               
               
                   
                 317. The conserved cyclophilin- 
                 
                   CTGEKGTGRSGKPLH FKGSSFHRVIPGFMCQGG DFTRGN 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   GTGGESIYGEKFADENFVKKHTGPGILSMANAGPNTNGS 
                 
               
               
                   
                 isomerase signature is underlined 
                 
                   QFFICTAQTSWLDGKHVVFGQVVEGLEVVRDIEKVGSGS 
                 
               
               
                   
                 and the cyclophilin-type peptidyl- 
                 
                   GRTSKPVVIADSGQLA 
                 
               
               
                   
                 prolyl cis-trans isomerase 
               
               
                   
                 signature is in bold. 
               
               
                   
               
               
                 52 
                 The amino acid sequence of SEQ ID 
                 MRFTSITSAIALFAAAASALDKPLDIKVDKAV ECSRKTK   
               
               
                   
                 318. The conserved FKBP-type 
                 
                   AGDKIQVHYRGTLEADGSEFDASYKRGQPLSFHVGKGQ V   
                 
               
               
                   
                 peptidyl-prolyl cis-trans 
                 
                     IKGWDQGLLDMCPGEKRTLTIQPDWGYG SRGMGPIPANS 
                 
               
               
                   
                 isomerase signature is underlined 
                   VLIFETELV EIAGVAREEL 
               
               
                   
                 and the FKBP-type peptidyl-prolyl 
               
               
                   
                 cis-trans isomerase signature 2 is 
               
               
                   
                 in bold. 
               
               
                   
               
               
                 53 
                 The amino acid sequence of SEQ ID 
                 MGNP KVFFDMSIGGQPAGRIVMELYADVVPRTAENFRAL   
               
               
                   
                 319. The conserved cyclophilin- 
                 
                   CTGEKGAGRSGKPLH YKGSSFHRVIPGFMCQGG DFTAGN 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   GTGGESIYGSKFADENFVKKHTGPGVLSMANAGPGTNGS 
                 
               
               
                   
                 isomerase signature is underlined 
                 
                   QFFVCTAKTEWLDGKHVVFGQIVDGMDVVKAIEKVGSSS 
                 
               
               
                   
                 andThe cyclophilin-type peptidyl- 
                 
                   GRTSKPVVVADCGQLS 
                 
               
               
                   
                 prolyl cis-trans isomerase 
               
               
                   
                 signature 2 is in bold. 
               
               
                   
               
               
                 54 
                 The amino acid sequence of SEQ ID 
                 MAVATRSRWVAMSVAWILVLFGTLALIQNRLSDTGASSD 
               
               
                   
                 320. The conserved FKBP-type 
                 PKLVHRKVGEEKKKPDDLEEVTH KVFFDVEIGGKPAGRI   
               
               
                   
                 peptidyl-prolyl cis-trans 
                 
                   VMGLFGKTVPKTVENFRALCTGEKGIGKSGKPLN YKGSQ   
                 
               
               
                   
                 isomerase signature is underlined 
                 
                     FHRIIPKFMIQGG DFTLGDGRGGESIYGNKFSDENFKLK 
                 
               
               
                   
                 and the Cyclophilin-type peptidyl- 
                 
                   HTDAGRLSMTNAGPDTNGSQFFITTVTTSWLDGRHVVFG 
                 
               
               
                   
                 prolyl cis-trans isomerase 
                   KVLSGMDVVHKIEAEGGQSGQPKSIVVISDSGELD L 
               
               
                   
                 signature is in bold. 
               
               
                   
               
               
                 55 
                 The amino acid sequence of SEQ ID 
                 
                   MAVTLHTNLGDIKCEIFCDEVPKAAEHNARGILSMANSG 
                 
               
               
                   
                 321. The conserved cyclophilin- 
                 
                   PNTNGSQFFIAYAKQPHLNGLYTIFGRVIHGFEVLDIME 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                   KTQTGPGDRPLAEIRLNRVTIHA NPLAG 
               
               
                   
                 isomerase signature is underlined 
               
               
                   
               
               
                 56 
                 The amino acid sequence of SEQ ID 
                 MAVATRSRWVAMSVAWILVLFGTLALIQNRLSDTGASSD 
               
               
                   
                 322. The conserved FKBP-type 
                 PKLVHRKVGEEKKKPDDLEEVTH KVFFDVEIGGKPAGRI   
               
               
                   
                 peptidyl-prolyl cis-trans 
                 
                   VMGLFGKTVPKTVENFRALCTGEKGIGKSGKPLN YKGSQ   
                 
               
               
                   
                 isomerase signature is underlined 
                 
                     FHRIIPKFMIQGG DFTLGDGRGGESIYGNKFSDENFKLK 
                 
               
               
                   
                 and the Cyclophilin-type peptidyl- 
                 
                   HTDAGRLSMANAGPDTNGSQFFITTVTTSWLDGRHVVFG 
                 
               
               
                   
                 prolyl cis-trans isomerase 
                   KVLSGMDVVHKIEAEGGQSGQPKSIVVISDSGELD L 
               
               
                   
                 signature is in bold. 
               
               
                   
               
               
                 57 
                 The amino acid sequence of SEQ ID 
                 MGNP KVFFDMSIGGQPAGRIVMELYADVVPRTAENFRAL   
               
               
                   
                 323. The conserved cyclophilin- 
                 
                   CTGEKGAGRSGKPLH YKGSSFHRVIPGFMCQGG DFTAGN 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   GTGGESIYGSKFADENFVKKHTGPGVLSMANAGPGTNGS 
                 
               
               
                   
                 isomerase signature is underlined 
                 
                   QFFVCTAKTEWLDGKHVVFGQIVDGMDVVKAIEKVGSSS 
                 
               
               
                   
                 andThe cyclophilin-type peptidyl- 
                 
                   GRTSKPVVVADCGQLS 
                 
               
               
                   
                 prolyl cis-trans isomerase 
               
               
                   
                 signature 2 is in bold. 
               
               
                   
               
               
                 58 
                 The amino acid sequence of SEQ ID 
                 MSPVAANAMEEA AEPEVPAPVTPSKDDADTDAAVSRFLG   
               
               
                   
                 324. The conserved A-box of the 
                 
                   FCKSKLGLAEGNCVQSSTLLRKTAHVLRSSGTVIGTGTA 
                 
               
               
                   
                 Retinoblastoma-associated protein 
                 
                   EEAERYWFAFVLYTVRRVGERKAEDEQNGSDETEVPLSR 
                 
               
               
                   
                 is underlined and the B-box of the 
                 
                   ILKASVLNLIDFFKEIPQFVIKAGAIVSGIYGANWDSRL 
                 
               
               
                   
                 Retinoblastoma-associated protein 
                 
                   EAREMQTNYVHLCILCKFYKRICGEFFILNDAKDDMKSA 
                 
               
               
                   
                 is in bold. 
                   DSSTSDPVIMYQPFGWLLF LALRIHALSRFKDLVSSTNA 
               
               
                   
                   
                 LVSVLAILIIHLPTRFRKFSISDSSQLVKRSEKGVDLVG 
               
               
                   
                   
                 SLAYRYDTSEDEIKRTLEKANNVIAEILGITPPPASECK 
               
               
                   
                   
                 AENLENVDTDGLIYFGNLMEETSLSSILSTLEKIYEDAT 
               
               
                   
                   
                 RNDSEFDERVFINDDDSLLVSGSLSGAAINLTGAKRKYD 
               
               
                   
                   
                 SFASPAKTITRPLSPSRSPASHINGIIGGTNLRITATPV 
               
               
                   
                   
                 ATAMTTAKWLRTFVSPLPSKPSTDLQGFLASCDRDVTSD 
               
               
                   
                   
                 VIRRANIILEAIFPNSPIGERTVTGGLQNANLMDNMWAE 
               
               
                   
                   
                 QRRLEALKLYYRVLEAMCRAEAQILHSNNLTSLLTNERF 
               
               
                   
                   
                 HRCMLACSAELVLATHKTVTMLFPAVLERTGITAFDLSK 
               
               
                   
                   
                 VIESFVRHEETLPRELRRHLNTLEERLLENMVWERGSSM 
               
               
                   
                   
                 YNSLVVARPALAPEINRLGLLPEPMPSLDAIALLINFSS 
               
               
                   
                   
                 SGLPQSPVQKHEASPGQNGDIRSPKRISTEYRSVLVERN 
               
               
                   
                   
                 FTSPVKDRLLALSNIKSKLPPPPLQSAFASPTRPHPGGG 
               
               
                   
                   
                 GETCAE TAIHIFFSKITKLAAVRINAMLERLQLSQQIKE   
               
               
                   
                   
                 
                   GVYCLFQQILSQRTNLFFNRHIDQVILCCFYGVAKINQI 
                 
               
               
                   
                   
                 
                   NLTFREIIYNYRKQPQCKPQVFRNVFVDWSTRRNGKAGN 
                 
               
               
                   
                   
                   EHVDIISFYNEIFIPSVKPLLVELGP TGATTRTNRTSEV 
               
               
                   
                   
                 GNKNDAQCPGSPKISSFPTLPDMSPKKVSASHNVYVSPL 
               
               
                   
                   
                 RSSKMDASISHSSKSYYACVGESTHAYQSPSKDLVAINS 
               
               
                   
                   
                 RLNGNRKVRGTLNFDDVDAGLVSDSMVANSLYLQNGSSM 
               
               
                   
                   
                 SSSTAKSSEK 
               
               
                   
               
               
                 59 
                 The amino acid sequence of SEQ ID 
                 MRPILMKGHERPLTFLKYNREGDLLFSCAKDHTPTVWFA 
               
               
                   
                 325. The conserved G-protein beta 
                 DNGE RLGTYRGHNGAVWCCDVSRDSMRLITGSADTTAKL   
               
               
                   
                 WD-40 repeat domains are 
                   WS VQNGTQLFTFNFDSPARSVDFSIGDKLAVITTDPFME 
               
               
                   
                 underlined. 
                 LPSAIHVKRIARDPADQASESVLVLRGHQGRIARAVWGP 
               
               
                   
                   
                 LNKTIISAGEDAVIRIWDSETGKLLR ESDKETGHKKAVT   
               
               
                   
                   
                   SLMKSVDGSHFVTGSQDKSAKLWD IRTLTLIKTYVTERP 
               
               
                   
                   
                 VNAVTMSPLLDHVVLGGGQDASAVTMTDHRAGKFEAKFF 
               
               
                   
                   
                 DKILQE EIGGVKGHFGPINALAFNPDGKSFSSGGEDGYV   
               
               
                   
                   
                   RLHH FDPDYFNIKI 
               
               
                   
               
               
                 60 
                 The amino acid sequence of SEQ ID 
                 MDKKR   TVVPLVCHGHSRPVVDLFYSPITPDGFFLISASK     
               
               
                   
                 326. The conserved G-protein beta 
                 
                     DSSPMLRN GET GDWIGTFEGHKGAVWSCCLDTNALRAAS   
                 
               
               
                   
                 domain is underlined and the WD-40 
                 
                     GSADFSAKLWD ALS GDELHSFEHKHIVRSCAFSEDTHLL   
                 
               
               
                   
                 repeat domains are in bold 
                 
                     LTGGVEKILRIFD LNRP DAPPREVDNSPGSIRTVAWLHS   
                 
               
               
                   
                   
                 
                     DQTILSSCTDIGGVRLWD VRS GKIVQTLETKSPVTSSEV   
                 
               
               
                   
                   
                 
                     SQDGRYITTADGSTVKFWD ANHFGLVKSYNMPCNIESAS 
                 
               
               
                   
                   
                 
                   LEPKLGNKFIAGGEDMWVHIFDFHT GEEIGCNKGHHGPV   
                 
               
               
                   
                   
                     HCVRFSPGGESYASGSEDGTIRIWQ   TGPANNVEGDANPS 
               
               
                   
                   
                 NGPVTGKAKVGADEVTRKVEDLQIGKEGKDWREG 
               
               
                   
               
               
                 61 
                 The amino acid sequence of SEQ ID 
                 MAEGLI LKGTMRAHTDMVTAIAIPIDNSDMVVTSSRDKS   
               
               
                   
                 327. The conserved G-protein beta 
                   IILWH LTKEEKVYGV PRRRLTGHSHFVQDVVLSSDGQFA1   
               
               
                   
                 WD-40 repeat domains are 
                   LSGSWDGELRLWD LATGV SARRFVGHTKDVLSVAFSIDN   
               
               
                   
                 underlined. 
                   RQIVSASRDRTIKLWN TLGECKY TIQEGEAHTDWVSCVR   
               
               
                   
                   
                   FSPNTLQPTIVSASWDRTIKVWN LTNCK RNTLAGHNGY   
               
               
                   
                   
                   VNTVAVSPDGSLCASGGKDGVILLWD LAEGKRLYNLEAG 
               
               
                   
                   
                 AIIHSLCFSPNRYWLCAATENSIKIWDLESKSIVEDLRV 
               
               
                   
                   
                 DLKNEADKTDGTTTAASNKKVIYCTSLNWSADGSTLFSG 
               
               
                   
                   
                 YNDGVIRVWGTGRY 
               
               
                   
               
               
                 62 
                 The amino acid sequence of SEQ ID 
                 MAEGLHLKGTMKAHTDMVTAIAVPIDNADMIVTSSRDKS 
               
               
                   
                 328. The conserved G-protein beta 
                 IILWHLTKEDKV YGVPRRRLTGHSHFVQDVVLSSDGQFA   
               
               
                   
                 WD-40 repeat domains are 
                   LSGSWDGELRLWD LA TGVSARRFVGHTKDVLSVAFSIDN   
               
               
                   
                 underlined. 
                   RQIVSASRDRTIKLWN T LGECKYTIQEGEAHNDWVSCVR   
               
               
                   
                   
                   FSPNTLQPTIVSASWDRTVKVWN LT NCKLRNTLQGHSGY   
               
               
                   
                   
                   VNTVAVSPDGSLCASGGKDGVILLWD LAEGKKLYSLEAG 
               
               
                   
                   
                 AIIHSLCFSPNRYWLCAATENSIKIWDLESKSIVEDLRV 
               
               
                   
                   
                 DLKNEADMSDGTTGAMSSNKKVIYCTSLNWSADGSTLFS 
               
               
                   
                   
                 GYNDGVIRVWGIGRY 
               
               
                   
               
               
                 63 
                 The amino acid sequence of SEQ ID 
                 MAEG LHLKGTMKAHTDMVTAIAVPIDNADMIVTSSRDKS   
               
               
                   
                 329. The conserved G-protein beta 
                   IILWH LTKEDKVY GVPRRRLTGHSHFVQDVVLSSDGQFA   
               
               
                   
                 WD-40 repeat domains are 
                   LSGSWDGELRLWD LAT GVSARRFVGHTKDVLSVAFSIDN   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                   RQ IVSASRDRTIKLWN     T LGEC KYTIQEGEAHNDWVSCVR   
               
               
                   
                 repeats signature is in bold. 
                   FSPNTLQPT IVSASWDRTVKVWN     L TN CKLRNTLQGHSGY   
               
               
                   
                   
                   VNTVAVSPDGSLCASGGKDGVILLWD LAE GKKLYSLEAG   
               
               
                   
                   
                   AIIHSLCFSPNRYWLCAATENSIKIWD LESKSIVEDLRV 
               
               
                   
                   
                 DLKNEADMSDG TTGAMSSNKKVIYCTSLNWSADGSTLFS   
               
               
                   
                   
                   GYNDGVIRVWG IGRY 
               
               
                   
               
               
                 64 
                 The amino acid sequence of SEQ ID 
                 MSGVPAPPFATTTPENGTMSSNSPAFHRDSDDDDDQGEV 
               
               
                   
                 330. The conserved G-protein beta 
                 FLDDSDIIHEVAVDDEDLPDADDEADEAEEADDS LHIFT   
               
               
                   
                 WD-40 repeat domains are 
                   GHNGEVYSLACSPTDATLVATGAGDDKGFLWR IGHGD WA   
               
               
                   
                 underlined. 
                   VELQGHKDSISSLAFSLDGQLLASGSLDGVIQIWD VPSG 
               
               
                   
                   
                 N LKGTLDGPGGGIEWIRWHPKGHIILAGSEDSTVWMWN A 
               
               
                   
                   
                 DKMA YLNMFSGHGNSVTCGDFTPDGKTICTGSDDATLRI   
               
               
                   
                   
                   WN PKSGENIH VVKGHPYHAEGLTSMAISSDSGLAITGAK   
               
               
                   
                   
                   DGSVRIVN ISSGR VVSSLDAHADSVEFVGLALSSPWAAT   
               
               
                   
                   
                   GSLDQKLIIWD LQHS SPRATCDHEDGVTCLSWVGASRFL   
               
               
                   
                   
                   ASGCVDGKVRVWD SLSGD CVRTFHGHSDAIQSLSVSANE   
               
               
                   
                   
                 EFLVSVSIDGTARVFEIAEFH 
               
               
                   
               
               
                 65 
                 The amino acid sequence of SEQ ID 
                 MGTSQHQLSSCLQLLPRRRGNKNLIFRRTMASGGAAAVA 
               
               
                   
                 331. The conserved G-protein beta 
                 PPPGYKPYR HLKTLTGHVAAVSCVKFSNDGTLLASASLD   
               
               
                   
                 WD-40 repeat domains are 
                   KTLIIWS SAALS LLHRLVGHSEGVSDLAWSSDSHYICSA   
               
               
                   
                 underlined. 
                   SDDRTLRIWS SRSPFD CLKTLRGHTDFVFCVNFNPQSSL   
               
               
                   
                   
                   IVSGSFDETIRIWE VKTGR CLNVIRAHSMPVTSVHFNRD   
               
               
                   
                   
                   GSLIVSGSHDGSCKIWD TKNGAC LKTLIDDTVPAVSFAK   
               
               
                   
                   
                   FSPNGKFILVATLNDTLKLWN YATGK FLKIYTGHKNSVY   
               
               
                   
                   
                   CLTSTFSVTNGKYIVSGSEDRCICIWD LQGKN LIQKLEG   
               
               
                   
                   
                   HSDTVISVTCHPSENKIASAGLDSDRTVRIWL QDA 
               
               
                   
               
               
                 66 
                 The amino acid sequence of SEQ ID 
                 MP SQKIETGHQDIVHDVAMDYYGKRVATASSDTTIKIIG   
               
               
                   
                 332. The conserved G-protein beta 
                 VSNSSGSQ HLASLSGHKGPVWQVAWAHPKFGSILASCSY   
               
               
                   
                 WD-40 repeat domains are 
                   DGQVILWK EGNQNDWA QAHVFNDHKSSVNSIAWAPHELG   
               
               
                   
                 underlined. 
                   LCLACGSSDGNISVFT ARPDGGWD TTRIEQAHPVGVTSV   
               
               
                   
                   
                   SWAPSMAPGALVGSGLLDPVQKLASGGCDNTVKVWK LYN 
               
               
                   
                   
                 GTWKMD CFPALQMHSDWVRDVAWAPNLGLPKSTIASASQ   
               
               
                   
                   
                   DGTVVIWT VAKEGEQW QGKVLKDFKTPVWRVSWSLTGNL   
               
               
                   
                   
                   LAVADGNNNVTLWN EAVDGEWQQVTTVEP 
               
               
                   
               
               
                 67 
                 The amino acid sequence of SEQ ID 
                 MKIAG LKSVENAHDESVWAAAWVPATESRPALLLTGSLD   
               
               
                   
                 333. The conserved G-protein beta 
                   ETVKLWR PDELA LERTNAGHFLGVVSVAAHPSGVIAASA   
               
               
                   
                 WD-40 repeat domains are 
                   SIDSFVRVFD VDTNA TIATLEAPPSEVWQMQFDPKGTTL   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                   AVAGGGSASIKLWD TATWELNATLSIPRPEQPKPSEKGN 
               
               
                   
                 repeats signature is in bold. 
                 KKFVLSVAWSPDGRRLACGSMDGTISIFDVARAK FLHHL   
               
               
                   
                   
                   EGHFMPVRSLVFSPVEPRLLFSASDDAHVHMYD SEGKS L   
               
               
                   
                   
                   VGSMSGHASWVLSVDVSPDGAA LATGSSDRTVRLWD     L SM 
               
               
                   
                   
                 RA AVQTMSNHSDQVWGVAFRPMAGAGVRAGGRLASVSDD   
               
               
                   
                   
                   KSISLYD YS 
               
               
                   
               
               
                 68 
                 The amino acid sequence of SEQ ID 
                 MEIDLGNLAFDVDFHPSEQLVASGLITGDLLLYRYGDGS 
               
               
                   
                 334. The conserved G-protein beta 
                 
                   SPEKLLEVRAHGESCRAVRFINDGKAILTGSPDCSILAT 
                 
               
               
                   
                 WD-40 repeat domains are 
                   D VET GSVVARVENAHEAAVNRLVNLTESTIATGDDNGCI   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                   KVWD TRQ RSCCNTFSAHEDFISDMTFASDSMKLVVTSGD   
               
               
                   
                 repeats signature is in bold. 
                   GTLSVCN LR SNKVQTRSEFSEDELLSVVIMKNGRKVVCG   
               
               
                   
                   
                   TQSGTLLLYS WGFFKDCSDRFVDLSPSSVDALLKLDEDR 
               
               
                   
                   
                 IIAGTENGLISLIGILP NRIIQPIAEHSDHPIERLAFSH   
               
               
                   
                   
                   DKKF LGSISHDQTLKLWD     L NDILGSEDSPSSQAAIDDSD 
               
               
                   
                   
                 SDEMDVDANPPDSSKGNKKKHSGKGNDVGNANNFFADLGD 
               
               
                   
               
               
                 69 
                 The amino acid sequence of SEQ ID 
                 MSQQPSVILATASYDHTIRFWEAKSGR CYRTIQYPDSQV   
               
               
                   
                 335. The conserved G-protein beta 
                   NRLEITPHKRYLAVAGNPSIRLFD VNSNTPQ PVMSFDSH   
               
               
                   
                 WD-40 repeat domains are 
                   TNNVMAVGFQYDGNWMYSGSEDGTVRIWD LRARG CQREY   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                   ESRGAVNTVVLHPNQTELISGDQNGNIRVWD LTANSCS C   
               
               
                   
                 repeats signature is in bold. 
                   ELVPEVDTAVRSLTVMWDGSLVVAANNNGTCYVWR LLRG 
               
               
                   
                   
                 SQTMTNFE PLHKLQAHNGYILKCLLSPEFCEPHRY LATA     
               
               
                   
                   
                     SSDHTVKIWN     V EGFT LEKTLIGHQRWVWDCVFSVDGAYL   
               
               
                   
                   
                   ITASSDTTARLWS MSTSQDIRVYQGHHKATTCCALHDGA 
               
               
                   
                   
                 EGSPG 
               
               
                   
               
               
                 70 
                 The amino acid sequence of SEQ ID 
                 MEDAMDMEVEVEVEAEEHSPSSSNPSGSSFRRFGLKNSI 
               
               
                   
                 336. The conserved G-protein beta 
                 QTNFGSDYVFEITPKFDWSLMGVSLSSNAVKLYSPTT GQ   
               
               
                   
                 WD-40 repeat domains are 
                 
                   YCGECRGHSDTVNGISFSGPSSPHVLHSCSSDGTIRAWD 
                 
               
               
                   
                 underlined. 
                 TRSF KEVSCISAGPSQEIFSFSFGGSSDSLLSAGCKSQI   
               
               
                   
                   
                   LFWDWRN KKQVACLEDSHVDDVTQVCFVPHHQNKLISAS 
               
               
                   
                   
                 VDGLICIFDTAGDINDDEHMESVINVGTSIGKVGIFGQT 
               
               
                   
                   
                 FEKLWCLTHIETLSVWDWKEGTNEANFEDARKLASDSWS 
               
               
                   
                   
                 LDHIDYFVDCHSAEEGEGLWVIGGTNAGTLGYFPVKYKG 
               
               
                   
                   
                 GAAI GSPEAVLGGGHSDVVRSVLPMSGMAGTTSKTRGIF   
               
               
                   
                   
                   GWTGGEDGRLCCWL SDDSSATSRSWMSSNLVLKSSRSHH 
               
               
                   
                   
                 KKNRHQPY 
               
               
                   
               
               
                 71 
                 The amino acid sequence of SEQ ID 
                 MSQHQEYPMEYAADDYDVGEVEDDMYFHERVMGDSDTDE 
               
               
                   
                 337. The conserved G-protein beta 
                 DEEYDHLDNKITDTSAADARRGKDIQGIPWERLSVTREK 
               
               
                   
                 domain is underlined and the WD-40 
                 YRRTRIEQYKNYENVPQSGESSEKDCKPTRKGGNYYEFW 
               
               
                   
                 repeat domains are in bold 
                 RNTRSVKSTILHFQLRNLVWSTTKHDVYLMSHFSIIHWS 
               
               
                   
                   
                 SLTCKKTEVLDVYGHVAPREKHPGSLLEGFTQTQVSTLA 
               
               
                   
                   
                 VRDKLLIAGGFQGELICKNLDRPGVSYCCRTTYDDNAIT 
               
               
                   
                   
                 NAVEIYDYPSGAVHFMASNNDCGVRDFDMEKFELSRHFT 
               
               
                   
                   
                 FPWPVNHTSLSPDGKLLVIVGDNPEGIVVDSQR   GKTIRP     
               
               
                   
                   
                 
                     LQGHLDFSFASAWHPDGHIFATGNQDKTCRIWD IRNL SK   
                 
               
               
                   
                   
                     SVAVLKGNLGAIRSIRFTSDGRFMAMAEPADFVHVYD   VK 
               
               
                   
                   
                 SGYEKEQEIDFFGEISGVSFSPDTESLFVGVWDRTYGSL 
               
               
                   
                   
                 LQYNRCRNYSYLDSM 
               
               
                   
               
               
                 72 
                 The amino acid sequence of SEQ ID 
                 MGASSDPNPDVSDEHQKRSEIYTYEAPWHIYAMNWSVRR 
               
               
                   
                 338. The conserved G-protein beta 
                 DKKYRLAIASLLDHPAAAAAVPNRVEIVQLDDSTGEIRA 
               
               
                   
                 WD-40 repeat domains are 
                 DPNLSFDHPYPATKAAFVPDKDCQRADLLATSSDFLRIW 
               
               
                   
                 underlined. 
                 RIADDSSRVDLRSFL NGNKNSEFCRPLTSFDWNEAEPKR   
               
               
                   
                   
                   IGTSSIDTTCTIWD IERET VDTQLIAHDKEVYDIAWGGV   
               
               
                   
                   
                   SVFASVSADGSVRVFD LRDKEHSTIIYESSEPDTPLVRL 
               
               
                   
                   
                 GWNKQDPRYMATIIMDSAKVVVLDIRYPTMP VVELQRHQ   
               
               
                   
                   
                   ASVNAIAWAPHSSCHICTAGDDSQALIWD LSSMAQPVEG 
               
               
                   
                   
                 GLDPILAYTAGAEIEQLQWSSSQPDWVAIAFSLKLQ 
               
               
                   
               
               
                 73 
                 The amino acid sequence of SEQ ID 
                 MRGGGGGGDATGWDEDAYRES VLKEREVQTRTVFRAAFA   
               
               
                   
                 339. The conserved G-protein beta 
                   PSPSPSPSPDAVVVASSDGSVASYS ISACLSDHRLQSLR 
               
               
                   
                 WD-40 repeat domains are 
                 FADAKSQNVLEAE PACFLQGHDGPAYDVKFYGEGEDSLL   
               
               
                   
                 underlined. 
                   LSCGDDGRIRGWM WRDITSSEAHDHSQGNSAKPVLDLVN 
               
               
                   
                   
                 PQSRGPWGALSPIPENNALAVDVKRGSIYAAAGDSCAYC 
               
               
                   
                   
                 WDVECGK IKTVFKGHSDYLHCIAARNSSSQIITGSEDGT   
               
               
                   
                   
                   ARIWD CRSGKCVQVIDP DKDHKKGFFASVSCLALDASES   
               
               
                   
                   
                   WLVCGRGRDLSVWS ISASDCIAKISTNAPAQDVLFDDNQ 
               
               
                   
                   
                 ILLVGAEPLISRLDMNGAVLSQIHCAPQSVFSVSLHQSG 
               
               
                   
                   
                 VTAVGGYGGLVDVISQFGSHLCTFRCKCI 
               
               
                   
               
               
                 74 
                 The amino acid sequence of SEQ ID 
                 MEAPIIDPLQGDFPE VIEEYLEHGIMKCIAFNRRGTLLA   
               
               
                   
                 340. The conserved G-protein beta 
                   AGCTDGSCIIWD FETRGVA KELRDKECTAAITSVCWSKY   
               
               
                   
                 WD-40 repeat domains are 
                   GHRILVSASDKSLILWD VLSGEKIAHTTLQHTVLQACLH 
               
               
                   
                 underlined. 
                 PGSSTPSICLACPFSSAPMIVDLNTGSTTALPVLTADVS 
               
               
                   
                   
                 NGATPLSRNKTSDTSVTYSPCNACFNKHGDLVYAGTSKG 
               
               
                   
                   
                 EILIIDHKNVRV CAIVLVSGGAVIKNVVFSRNGQYMLTN   
               
               
                   
                   
                   SNDRLIRIYK NLLPPKDGLKMLDELNESFNESDDVEKLK 
               
               
                   
                   
                 AIGSKCLELLHEFQDSITRVQWKAPCFSGDGEWVIGGAA 
               
               
                   
                   
                 SRGEHKIYIWDRAGH LVKILEGPKEALMDLAWHPVHPII   
               
               
                   
                   
                   ISVSLTGLVYIWA KDYTENWSAFAPDFKELEENEEYVER 
               
               
                   
                   
                 EDEFDLVPETEKVKGLDVHEDDEVDVLTVERDSVFSDSD 
               
               
                   
                   
                 MSQEELCFLPAVPCLDIPEQQDKCVGSCSKLPDGNHSGS 
               
               
                   
                   
                 PLSVEAGQNGNASNHNSSPLEPMENSTADDTDGVRLKRK 
               
               
                   
                   
                 RKPSEKGLELQAEKVKKPVKPLKSSGRLSKTNKPVIDPD 
               
               
                   
                   
                 SSNGVYGDDGSD 
               
               
                   
               
               
                 75 
                 The amino acid sequence of SEQ ID 
                 MRGVSWPEDGNNPSTSSSSQRNQQQAHAPRAVSGHAASH 
               
               
                   
                 341. The conserved G-protein beta 
                 PSASNIFKLLVQREVSPRSKHSSKKLWREASKCQPYPFQ 
               
               
                   
                 WD-40 repeat domains are 
                 QSCEAVRDVRQGLISWVESASLRHL SAKYCPLVPPPRST   
               
               
                   
                 underlined. 
                   IAAAFSPDGKILASTHGDHTVKLID SQT GSCLKVLRGHR   
               
               
                   
                   
                   RTPWVVRFHPLYPEILASGSLDHEVRLWD ANT AECIGSR   
               
               
                   
                   
                   NFYRPIASIAFHARGELLAVASGHKLYIWH YNRRGETSS 
               
               
                   
                   
                 PTIVLRTQRSLRAVHFHPHAAPFLLTAEVNDLDSADSAM 
               
               
                   
                   
                 TLATSPGYLHYPPPTVYFADAHSHERSRLADELPLMPLP 
               
               
                   
                   
                 LLMWPSFTRDDGRVPLQRIDGDVGLNGQQRVDSSSSVRL 
               
               
                   
                   
                 WTYSTPSGQYELLLSPVESGNSPSMPEETGNNAFSSAVE 
               
               
                   
                   
                 AEVSQSAMDTVEDMEVQPEERNTQFFSFSDPRFWELPLL 
               
               
                   
                   
                 HGWLVGQTQAGPRSVRQSSPGDIETQSAFGEVASVSPIT 
               
               
                   
                   
                 SGVMPVSMDPSRFGGRSGSRYRSPGSRGVHVTGPNNDGP 
               
               
                   
                   
                 RDENDPQSVVSKLRSELAASLAAAASTELPCTVKLRIWP 
               
               
                   
                   
                 HDVKDPCAQLDLESCRLTIPHAVLCSEMGAHFSPCGRFL 
               
               
                   
                   
                 AACVACVLPHLESDPGLHGQVNQDVTGVATSPTRHPISA 
               
               
                   
                   
                 HQIMYELRIYSLEEATFGIVLASRPVRAAHCLTSIQFSP 
               
               
                   
                   
                 TSEHLLLAYGRRHSSLLKSIVIDGENTVPIYTILEVYRV 
               
               
                   
                   
                 SD MELVRVLPSAEDEVNVACFHPSVGGGLIYGTKEGKLR   
               
               
                   
                   
                   ILH YDSSHGLNLKSSGFLDENVPEVQTYALEC 
               
               
                   
               
               
                 76 
                 The amino acid sequence of SEQ ID 
                 MDSAVAIAALSLVVGAAIALLFFGNYFRKRRSEVVAMAE 
               
               
                   
                 342. The conserved G-protein beta 
                 ADLQPHPKNPSRPPPQPAAKKVHAKSHAHGADKDKNKRH 
               
               
                   
                 WD-40 repeat domains are 
                 HPL DLNTLKGHGDSVTGLCFASDGRSLATACADGVVRVF   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                   K LDDASNKSFKFLRINLPAGGHPTAVAFGDGVSSVIVAS 
               
               
                   
                 repeats signature is in bold. 
                 QHLSGCSLYMYGEEKPTNLDSNKQQTKLPMPEIKWEHH K   
               
               
                   
                   
                 
                   VHEQKAILTLSGAAANYDSGDGSTIIASCSEGTDIIIWH 
                 
               
               
                   
                   
                 AKTGK ILGNVDTNQLKNTMSAISPNGRFIAAAAFTADVK   
               
               
                   
                   
                   VWE IVYSKDGSVKGVT KVMQLKGHKSAVTWLCFTPNSEQ   
               
               
                   
                   
                     IVTASKDGSIRIWN     I NVRYHLDEDTKTLKVFPIPLQDSS 
               
               
                   
                   
                 GTTLHYERLSLSPDGKILAATHGSMLQWLCIETGKV LDT   
               
               
                   
                   
                 
                   AEKAHDGDITCMSWAPQSIPTGDKKVNVLATASGDKKVK 
                 
               
               
                   
                   
                   LWA APPLPS 
               
               
                   
               
               
                 77 
                 The amino acid sequence of SEQ ID 
                 MEVEPKKASKTFPVKPKLKPKPRTPSGKTPESKYWSS FK   
               
               
                   
                 343. The conserved G-protein beta 
                 
                   TTHPLDNLSFSVPSLAFSPSPPHLLAAAHSATVSLFSPH 
                 
               
               
                   
                 WD-40 repeat domains are 
                   RTTISSFSDVVSSLSFRSDGQLLAASDLSGLIQVFD VRS 
               
               
                   
                 underlined. 
                 
                   RTPLRRLRSHARPVRFVRYPVLDKLHLVSGGDDALVKYW 
                 
               
               
                   
                   
                   D VAG ESVVSELRGHKDYVRCGDCSPADANCFVTGSYDHV   
               
               
                   
                   
                   VKLWD VRVRD GNRAATEVNHGSPVQDVIFLPSGSLVATA   
               
               
                   
                   
                   GGNSVKIWD LIGG GRMVYSMESHNKTVTSICVGTMGAQQ   
               
               
                   
                   
                   SGEEGVQLRILSVGLDGYMKVFD YSRMKVTHSMRFPAPL 
               
               
                   
                   
                 LSIGFSPDSNVRAIGTSNGILYVGKRKAKENAEGGANGI 
               
               
                   
                   
                 LGLGSVEEPRRRVLKPSFYRYFHRGQSEKPSEGDYLVMR 
               
               
                   
                   
                 PKKVKLAEHDKLLKKFQHKNALISVLGGNDPEKVVAVME 
               
               
                   
                   
                 ELVARRALLKCVLNLDADELGLILTFLHKNSTVPRYSSL 
               
               
                   
                   
                 LLGLAKKVIDLRLEDIRASDALKGHIRNLKRSVDEEIRI 
               
               
                   
                   
                 QEGLQEIQGMVSPLLRIAGRR 
               
               
                   
               
               
                 78 
                 The amino acid sequence of SEQ ID 
                 MQGGSSGVGYGLKYQARCISDVKADTDHTSFLTGTLSLK 
               
               
                   
                 344. The conserved G-protein beta 
                 EENEVHLLRLSSGGTELICEGLFSHPSEIWDLSSCPFDQ 
               
               
                   
                 WD-40 repeat domains are 
                 RIFSTVFSTGESYGAAVWQIPELYGQLNSPQ LEKIASLD   
               
               
                   
                 underlined. 
                 
                   AHSRKISCVLWWPSGRHDKLVSIDEENIFLWGLDCSKKS 
                 
               
               
                   
                   
                 
                   AQVQSQESAGMLHNLSGGAWDPHDVNTVAATCESSIQFW 
                 
               
               
                   
                   
                   D LRTMKKANSLESVHARDLDYDMRKKHLLVTSEDESGVR 
               
               
                   
                   
                 VWDLRMP KAPIQEFPGHTHWTWAVRCNPDYEGLILSAGT   
               
               
                   
                   
                   DSAVNLWW SSTASSDELISERLIDSPTRKL DPLLHSYND   
               
               
                   
                   
                   YEDSVYGLAWSSREPWIFASLSYDGRVVVES VKPFLSRK 
               
               
                   
               
               
                 79 
                 The amino acid sequence of SEQ ID 
                 MAEEEGSAELEQQLEEEFAVWKKNTPILYDLLISHALEW 
               
               
                   
                 345. The conserved G-protein beta 
                 PSLTVHWAPLLPQPSSSAAAAAGDPSLAAHRLVLGTHTS 
               
               
                   
                 WD-40 repeat domains are 
                 DGAPNFLILADALLPSSESDHCGDDAVLPKVEISQKIRV 
               
               
                   
                 underlined. 
                 DGEVNRARFMPQNHNIVGAKTNGCEVYVFDCSKQAAKQH 
               
               
                   
                   
                 DGGFDPDLRLTGHDGEGYGLSWSPLKENYLLSASHDKKI 
               
               
                   
                   
                 CLWDISAAAQDKV LGAMHVFEAHEGAVGDASWHSKNDNL   
               
               
                   
                   
                   FGSAGDDCQLMIWD LRT NKAQQCVKAHEKEVNSVSFNSY   
               
               
                   
                   
                   NDWILATASSDTTVGLFD MRKL TTPLHVFSSHEGEVLQV   
               
               
                   
                   
                   EWDPNHEAVLASSSEDRRVMVWD LNRIGDEQQEGDASDG 
               
               
                   
                   
                 P AELLFSHGGHKAKISDFSWNKNEPWVISSVAEDNSVQV   
               
               
                   
                   
                   WQ MAESICGDDDDMQAMEGYI 
               
               
                   
               
               
                 80 
                 The amino acid sequence of SEQ ID 
                 MGNYGEEDEDQYFDALEETASVSDRGSNSSDCCSSGSGL 
               
               
                   
                 346. The conserved G-protein beta 
                 DENVLDSLGFEFWTKFPESVRARRNRFLMLTGLGIEANS 
               
               
                   
                 WD-40 repeat domains are 
                 VDKEDAFPPSCNEIEVYTCKVTRDDGAVQRSLDSYNCIS 
               
               
                   
                 underlined. 
                 LLQSSTSIRSNQEVESLRGDSLLSSFRGRSKESDDLTEL 
               
               
                   
                   
                 CGMGCPESKRNAVSEFGSVSQGSIEELRRIVASSPLVHP 
               
               
                   
                   
                 LLHRKLEYERELIETKQKMGAGWLRKFGSATCISGRQGD 
               
               
                   
                   
                 TWSDPDDLEITAGMKMRRVRAHSSKKKYKELSSLYAAQE 
               
               
                   
                   
                 FLAHEGSISTMKFSMDGQY LASAGEDTVVRVWKV TEEDR 
               
               
                   
                   
                 SERVNVTVDPSCLYFALNESTQLASLNTNKEHIGKAKTF 
               
               
                   
                   
                 QRSSDSSCVILPLKVFQITEKPWHEFKGHNGEVLDLSWS 
               
               
                   
                   
                 SKGY LLSSSTDKTVRLWRV GCDRCQRVYSHNDYVTCISF 
               
               
                   
                   
                 NPVNENF FISGSIDGKVRIWNV FGGQVVAYIDCREIVSA 
               
               
                   
                   
                 VCYRSDGKGAIVGTMTGNCLFYSIKDNHLQMDAQVYLHG 
               
               
                   
                   
                 KKKSPGKRITGFQFPPNDPGKLMITSADSVIRVLSGLDV 
               
               
                   
                   
                 VCKLKGPRNSGGPMIATFTSDGKHVISASEDSNVYIWNY 
               
               
                   
                   
                 AGQDKTSSRVKKIWSCESFWSSNASVALPWCGIRTVPEA 
               
               
                   
                   
                 LAPPSRSEERRASCAENGENHHMLEEYFQKMPPYSPDCF 
               
               
                   
                   
                 SLSRGFFLELLPKGSATWPEEKLSDTSPPTVSSQAISKL 
               
               
                   
                   
                 EYKFLKSACHSVLSSAHMWGLVIVTAGWDGRIRTYHNYG 
               
               
                   
                   
                 LPVRS 
               
               
                   
               
               
                 81 
                 The amino acid sequence of SEQ ID 
                 MDIDFKEYR LRCELRGHEDDVRGVCVCGDGSIGTSSRDR   
               
               
                   
                 347. The conserved G-protein beta 
                   TVRLWA PSAGERRKYE VARVLLGHKSFVGPLAWVPPSEE   
               
               
                   
                 WD-40 repeat domains are 
                   LPEGGIVSGGMDTLVMAWD LRNG EAQTLKGHQLQVTGIV   
               
               
                   
                 underlined. 
                   LDGGDIVSASVDCTLIRWK NGQ LTEHWEAHKAPIQAVIR   
               
               
                   
                   
                   LPSGELVTGSSDTTLKLWR GKT CTQTFVGHTDTVRGLAV   
               
               
                   
                   
                   MPDLGILSASHDGSIRLWA VSGE CLMEMVDHTSIVYSVD   
               
               
                   
                   
                   SHASGLIVSGSEDRFAKIWK DGV CFQSIEHPGCVWDVKF   
               
               
                   
                   
                   LEDGDIVTACSDGTIRIWT NQEDRMANSTELELFDLELS 
               
               
                   
                   
                 SYKRSRKRVGGLKLEELPGLEALQVPGTSDGQTKVIREG 
               
               
                   
                   
                 DNGVAYAWNSTELKWDKIGEVVDGPEDSMNRPALDGVQY 
               
               
                   
                   
                 DYVFDVDIGDGEPTRKLPYNRSDNPYDTADKWLLKENLP 
               
               
                   
                   
                 LSYRQQIVEFILANSGQRDFNLDPSFRDPYTGSSAYVPG 
               
               
                   
                   
                 APSQLAAKQARPTFKHIPKKGMLVFDAAQFDGILKKINE 
               
               
                   
                   
                 FNNTLLSNQEKKNLSLTDIEISRLGAVVKILKDTSHYHS 
               
               
                   
                   
                 SKFADADFDLMLKLLESWPYEMMFPVIDIFRMVILHPDG 
               
               
                   
                   
                 ADGLLRHQEDKKDVLMESIKRATGNPSVPANFLTSIRAV 
               
               
                   
                   
                 TNLFKNSAYYSWLQKHRSEMLDAFSSCSSSSNKNLQLSY 
               
               
                   
                   
                 ATLLLNYAVLLIEKKDEEGQSQVLSAALELAENESLEVD 
               
               
                   
                   
                 ARYRALVAIGSLMLDGLVKRIALDFDVEHIAKAARTSKE 
               
               
                   
                   
                 AKIAEVGADIELLIKQS 
               
               
                   
               
               
                 82 
                 The amino acid sequence of SEQ ID 
                 MEFTEAYKQSGPCCFSPNARFIAVAVDYRLVIRDTLSLK 
               
               
                   
                 348. The conserved G-protein beta 
                 VVQLFSCLDKISYIEWALDSEYILCGLYKRPMIQAWSLI 
               
               
                   
                 domain is underlined and the WD-40 
                 QPEWTCKIDEGPAGIAYARWSPDSRHILTTSDFQLRLTV 
               
               
                   
                 repeat domains are in bold 
                 WSLVNTACVHVQWPKHASKGVSFTRDGKFAAICTRHDCK 
               
               
                   
                   
                 DYINLLSCHNWEIMGVFAVDTLDLADIQWSPDDSAIVIW 
               
               
                   
                   
                 DSPLEYKVLVYSPDGR   CLFKYQAYESGLGVKSVSWSPCG     
               
               
                   
                   
                 
                     QFLAVGSYDQMLRVLS HLTWKTFAEFTHLSNVRAPCCAA 
                 
               
               
                   
                   
                 
                   IFKEVDEPLQIDMSELSLSDDYMQGNSGDAPEGHYRVRY 
                 
               
               
                   
                   
                 
                   DVTEVPITLPCQKPPADRPNPKQGIGLMSWSNDSQYICT 
                 
               
               
                   
                   
                 
                   RNDSMPTILWIWDMRH LELAAILVQKDPIRAAVWDPTGT   
                 
               
               
                   
                   
                     RLVLCTGSSHLYMWT   PSGAYCVSVPLSQFNITDLKWNSD 
               
               
                   
                   
                 GSCLLLKDKESFCCAAAPLPPDESSDYSSDD 
               
               
                   
               
               
                 83 
                 The amino acid sequence of SEQ ID 
                 MATIAALDDDMVRSMS IGAVFSDFVGKLNSLDFHRKDDI   
               
               
                   
                 349. The conserved G-protein beta 
                   LVTAGEDDSVRLYD IANARLLKTTFHKKHGTDRVCFTHH 
               
               
                   
                 WD-40 repeat domains are 
                 PNSLICSSTKNLDTGESLRYISMYDNR SLRYFKGHKQRV   
               
               
                   
                 underlined. 
                   VSLCMSPINDSFMSGSLDHSVRMWD LRVNACQGILRLRG 
               
               
                   
                   
                 RPTVAYDQQGLVFAVAMEGGAIKLFDSRSYDKGPF DAFL   
               
               
                   
                   
                   VGGDTSEVCDIKFSNDGKSVLLSTTNNNIYVLD AYAGDK 
               
               
                   
                   
                 QC GFNLEPSPSTPIEASFSPDGQYVVSGSGDGTLHAWN I 
               
               
                   
                   
                 SRRNEVACWNSHIGVASCLKWAPRRAMFVAASTVLTFWI 
               
               
                   
                   
                 PNSEPELASAKGEAGVPPEQV 
               
               
                   
               
               
                 84 
                 The amino acid sequence of SEQ ID 
                 MSVAELKERHRAATETVNSLRERLKQKRVQLLDTDVAGY 
               
               
                   
                 350. The conserved G-protein beta 
                 ARTQGKTPVTFGATDLV CCRTLQGHTGKVYSLDWTPERN   
               
               
                   
                 WD-40 repeat domains are 
                   RIVSVSQDGRFIVWN ALTSQ KTHAIRLPCAWVMTCAFA P     
               
               
                   
                 underlined and the beta G-protein 
                     NGQSVACGGLDSVCSIF N LNSPVDRDGNLP VSRMLSGHK   
               
               
                   
                 (transducin) is in bold. 
                   GYVSSCQYVPDGDAHLITGSGDQTCVLWD ITTGLRTSVF 
               
               
                   
                   
                   GGEFQSGHTADVLSVSINGSSPRIFVSGSCDSTARMWD T 
               
               
                   
                   
                 RVASR AVHTYHGHEGDVNAVKFFPDGNRFGTGSDDGTCR   
               
               
                   
                   
                   LFD IRTGHELQVY YQQRGIDEIPHVTSIAFSISGRLLIA   
               
               
                   
                   
                   GYSNGDCFVWD TLLAQVVLN LGSLQNSHEGRISCLGVSA   
               
               
                   
                   
                   DGSALCTGSWDTNLKIWA FGGIRRVT 
               
               
                   
               
               
                 85 
                 The amino acid sequence of SEQ ID 
                 MKKRPRGASLDQAVVDIRRREVGGLSGLSFARRLAASEG 
               
               
                   
                 351. The conserved G-protein beta 
                 LVLR   LDIYNKLKGHRGCVNTVGFNLDGDIVISGSDDRHV     
               
               
                   
                 domain is underlined and the WD-40 
                 
                     KLWD WQ TGKVKLSFDSGHLSNVFQAKIMPYTDDRSIVTC   
                 
               
               
                   
                 repeat domains are in bold 
                 
                     AADGQARHAQ ILEGG QVQTMLLAKHRGRAHKLAIDPGSP   
                 
               
               
                   
                   
                 
                     HIVYTCGEDGLVQRLD LRSNTAREL FTCREVYGTHVEVV   
                 
               
               
                   
                   
                 
                     HLNAIAIDPRNPNLFVIGGSDEYARVYD IRNYKWNGSHN 
                 
               
               
                   
                   
                 
                   FGRSANYF CPSHLIGEAHVGITGLAFSGQSELLVSYNDE   
                 
               
               
                   
                   
                 
                     SIYLFT QEMGLGPDPLSASTKSVDSNSSEVTSPTAVNVD 
                 
               
               
                   
                   
                 
                   D NVTPQVYKGHRNCETVKGVGFFGPKCEYVVSGSDCGRI   
                 
               
               
                   
                   
                 
                     FIWK KKG GQLIRVMAADKHVVNCIEPHPHIPALASSGIE   
                 
               
               
                   
                   
                     NDIKIWT   PKAIERATLPMNVEQLKPKARGWMNRISSPRQ 
               
               
                   
                   
                 LLLQLYSLERWPEHGGETSSGLAASQEELTELFFALSAN 
               
               
                   
                   
                 GNGSPDGGGDPSGPLL 
               
               
                   
               
               
                 86 
                 The amino acid sequence of SEQ ID 
                 MSKR GYKLQEFVAHSSNVNCLSIGKKACRLFLTGGDDCK   
               
               
                   
                 352. The conserved G-protein beta 
                   VNLWA IGK PNSLMSLCGHTNAVESVAFDSAEVLVLAGAS   
               
               
                   
                 WD-40 repeat domains are 
                   SGVIKLWD VEE AKLVRGLTGHRSNCTAMEFHPFGEFFAS   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                   GSTDTNLKIWD IRK KGCIHTYKGHTRGISTIRFSPDGRW   
               
               
                   
                 repeats signature is in bold. 
                   VVSGGNDNVVKVWD LTA GKLLHDFKFHENHIRSIDFHPL   
               
               
                   
                   
                   EFL LATGSADRTVKFWD     L ET FELIGSSRPEAAGVRAIAF   
               
               
                   
                   
                   HPDGRTLFCGLEDSLKVYS WEPVICHDGVDMGWSTLADL 
               
               
                   
                   
                 CIHDGKLLGCSYYQSSVGVWVADASLIEPYGTNVKPQQK 
               
               
                   
                   
                 DSGDDEIEHQESRPSAKVGTTIRSTSIMRCASPDYETKD 
               
               
                   
                   
                 IKNIYVDTASGNPVSSQRVGTTNFAKVTQPLDFNDTPNL 
               
               
                   
                   
                 TLRRQGLVTETPDGLSGHVPSKSITQPKVVSRDSPDGKD 
               
               
                   
                   
                 SSRRESITFSRTKPGMLLRPAHSRRPSSTKYDVDRLSAC 
               
               
                   
                   
                 AEIGVLSSAKSGSESLVDSFLNIKVAPEDGARNGCEDNH 
               
               
                   
                   
                 SSVKNVSVESEKVLPLQTPKTEKCDQTVGFKEEINSVKF 
               
               
                   
                   
                 VNGVAVVPGRTRTLVEKFEKREKLNSTEDQTINTPENPT 
               
               
                   
                   
                 LDKTPPPSLAENEEKSDRLNIVERKATRMSSHMVTAEDR 
               
               
                   
                   
                 TPVTLVGSPEDQSTVMAPQRELPADESSKTPPLPVEDLE 
               
               
                   
                   
                 IHHGSNVSEDKATILSSQTVSEEDSKRSTLIRNFRRRDR 
               
               
                   
                   
                 FKSTEGRSPVMATQRKLPTDESGKTSSLPMEDLEIKGGL 
               
               
                   
                   
                 NVSEDKATSFSSRAPPREDRAHSALVRNVRKRDKFKSTN 
               
               
                   
                   
                 DTITVMVHQRGLSTDEASTVSVERVERRQLSNNVENPLN 
               
               
                   
                   
                 NLPPHSVPPTTTRGEPQYVGSESDSVNHEDVTELLLGNH 
               
               
                   
                   
                 EVFLSTLRSRLTKLQVV 
               
               
                   
               
               
                 87 
                 The amino acid sequence of SEQ ID 
                 MSTFLTGTALSNPNPNK SYEVVQPPNDSVSSLSFNPKAN   
               
               
                   
                 353. The conserved G-protein beta 
                   FLVATSWDNQVRCWE IVRSGTSLGT TPKASISHDQPVLC   
               
               
                   
                 WD-40 repeat domains are 
                   STWKDDGTTVFSGGCDKQVKMWP LSGG QPMTVAMHDAPI   
               
               
                   
                 underlined. 
                   KEISWIPEMNLLVTGSWDKTLRYWD TRQAN PVHIQQLPE   
               
               
                   
                   
                   RCYALTVRHPLMVVGTADRNLIIYN LQSPQTEFKRISSP 
               
               
                   
                   
                 LKYQTRCLAAFPDQQGFLVGSIEGRVGVHHLDDSQQSKN 
               
               
                   
                   
                 FTFK CHREGSEIYSVNSLNFHPVHHTFATAGSDGAFNFW   
               
               
                   
                   
                   D KDSKQRLKAMSRCSQPIPCSTFNNDGSIFAYSACYDWS 
               
               
                   
                   
                 KGAENHNPATAKTYIFLHLPQESEVKGKPRLGTTGRK 
               
               
                   
               
               
                 88 
                 The amino acid sequence of SEQ ID 
                 MEVEAQQRDVNNVMCQLVDPEGTTLGPPMYLPQDVGPQQ 
               
               
                   
                 354. The conserved G-protein beta 
                 LQQMVNKLLSNEDKLPYTFYISDQELVVPLESYLQKNKV 
               
               
                   
                 WD-40 repeat domains are 
                 SVEKVLSIVYQPQAIFRIRPVNR CSATIAGHSEAVLSVA   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                   FSPDGKQ LASGSGDTTVRLWD     L STQTP MFTCKGHKNWVL   
               
               
                   
                 repeats signatures are in bold. 
                   SIAWSPDGKHLVSGSKAGEIQCWD PLTGQP SGNPLVGHK   
               
               
                   
                   
                   KWITGISWEPVHLSSPCRRFVSSSKDGDARIWD VTLRR C   
               
               
                   
                   
                   VICLSGHTLAVTCVKWGGDGVIYTGSQDCTIKVWE TSQG 
               
               
                   
                   
                 K LIRELKGHGHWVNSLALSTEYVLRTGAFDHTGKQYS SA 
               
               
                   
                   
                 EEMKQVALERYKKMKGNAPERLVSGSDDFTMFLWEPSVS 
               
               
                   
                   
                 KH PKTRMTGHQQLVNHVYFSPDGQW VASASFDKSVKLWN     
               
               
                   
                   
                   G ITGK FVAAFRGHVGPVYQISWSADSR LLLSGSKDSTLK     
               
               
                   
                   
                     IWD   IRTKK LKRDLPGHADEVFAVDWSPDGEKVVSGGKDK   
               
               
                   
                   
                 VLKLWMG 
               
               
                   
               
               
                 89 
                 The amino acid sequence of SEQ ID 
                 MDAGSAHSSSNMKTQSRSPLQEQFLQRRNSRENLDRFIP 
               
               
                   
                 355. The conserved G-protein beta 
                 NRSAMDFDYAHYMLTEGRKGKENPAVSSPSREAYRKQLA 
               
               
                   
                 WD-40 repeat domains are 
                 ETLNMNRTRILAFKNKPPTPVELIPHELTSAQPAKPTKT 
               
               
                   
                 underlined. 
                 RRYIPQTSERTLDAPDLLDDYYLNLLDWGSSNVLSIALG 
               
               
                   
                   
                 NTVYLWNASDGSTS ELVTIDDETGPVTSVSWAPDGRHIA   
               
               
                   
                   
                   VGLNNSDVQLWD SADNRL LRTLRGGHRSRVGSLAWNNHI   
               
               
                   
                   
                   LTTGGMDGLIVNND VRVRSH IVDTYRGHTQEVCGLKWSA   
               
               
                   
                   
                   SGQQLASGGNDNILHIWD RSTASSNSPTQ WLHRLEEHTA   
               
               
                   
                   
                   AVKALAWCPFQGNLLASGGGGGDRTIKFWN THTGACLNS 
               
               
                   
                   
                 VDTGSQVCALLWNKNERELLSSHGFTQNQLTLWKYPSMV 
               
               
                   
                   
                   KIAELTGHTSRVLFMAQSPDGCTVASAAGDETLRFWN VF 
               
               
                   
                   
                 GVPEVAKPAPKANPEPFAHLNRIR 
               
               
                   
               
               
                 90 
                 The amino acid sequence of SEQ ID 
                 MEEAIPFK NLPSREYQGHKKKVHSVAWNCTGTKLASGSV   
               
               
                   
                 356. The conserved G-protein beta 
                   DQTARVWH IEPHGHG KVKDIELKGHTDSVDQLCWDPKHA   
               
               
                   
                 WD-40 repeat domains are 
                   DL IATASGDKTVRLWD     A RSGKCSQQAELSGENINITYKP 
               
               
                   
                 underlined and the Trp-Asp (WD) 
                 DGTHVAVGNRDDELTILDVRKFKPIHKRKFNYEVNEIAW 
               
               
                   
                 repeats signature is in bold. 
                 NMSGEMFFLTTGNGTVEVLAYPS LRPVDTLMAHTAGCYC   
               
               
                   
                   
                   IAIDPVGRYFAVGSADSLVSLWD ISE MLCVRTFTKLEWP   
               
               
                   
                   
                   VRTISFNHTGDYVASASEDLFIDISN VQTGRTVHQIPCR 
               
               
                   
                   
                 AAMNSVEWNPKYNLLAYAGDDKNKYQADEGVFRIFGFESA 
               
               
                   
               
               
                 91 
                 The amino acid sequence of SEQ ID 
                 MGKDEEEMRGEIEERLINEEYKVWKKNTPFLYDLVITHA 
               
               
                   
                 357. The conserved G-protein beta 
                 LEWPSLTVEWLPDREEPPGKDYSVQKLVLGTHTSENEPN 
               
               
                   
                 WD-40 repeat domains are 
                 YLMLAQVQLPLEDAENDARHYDDDRADVGGFGCANGKVQ 
               
               
                   
                 underlined. 
                 IIQQINHDGEVNRARYMPQNSFIIATKTVSAEVYVFDYS 
               
               
                   
                   
                 KHPSKPPLDGA CSPDLRLRGHSTEGYGLSWSKFKQGHLL   
               
               
                   
                   
                   SGSDDAQICLWD INATPKNKS LDAMQIFKVHEGVVEDVA   
               
               
                   
                   
                   WHLRHEYLFGSVGDDQYLLIWD LRTPSV TKPVQSVVAHQ   
               
               
                   
                   
                   SEVNCLAFNPFNEWVVATGSTDKTVKLFD LRKI STALHT   
               
               
                   
                   
                   FDAHKEEVFQVGWNPKNETILASCCLGRRLMVWD LSRID 
               
               
                   
                   
                 EEQTPEDAEDGP PELLFIHGGHTSKISDFSWNTCEDWVV   
               
               
                   
                   
                   ASVAEDNILQIWQ MAENIYHDEDDVPGEESNKGS 
               
               
                   
               
               
                 92 
                 The amino acid sequence of SEQ ID 
                 MMRGFSCTEDGDAPSTSSTSPPPPPPPPHRQQMQAPRAS 
               
               
                   
                 358. The conserved G-protein beta 
                 SSSSGQPTSRRSTGNVFKLLARREVSPRSKHSLKKFWGE 
               
               
                   
                 WD-40 repeat domains are 
                 ASECQLCPFQQSYEAVRDVRRSLISWVEAFSLQHLS AKY   
               
               
                   
                 underlined. 
                   CPLMPPPRSTIAAAFSPDGKILASTHGDHTVKLID SQT G   
               
               
                   
                   
                 
                   SCLKVLRGHRRTPWVVRFHPLYPEILASGSLDHEVHLWD 
                 
               
               
                   
                   
                 ANT AECIGSRNFYRPIASIAFHAQGDLLAVASGHKLYIW   
               
               
                   
                   
                   H YNRSGETSSPTIVLRTPRSLRAVHFHPHAAPFLLTAEV 
               
               
                   
                   
                 NDLDLTDSAMTLATSPGYLHYPPPTIYLADAHSNERSRL 
               
               
                   
                   
                 EDELPLMPSPLLMWPSFTRDDGRATLPHIGGDVGLSGQQ 
               
               
                   
                   
                 RVDSLSSGQYEFHPSPIEPSSSTSMHEEMGTDPFSSVRE 
               
               
                   
                   
                 SEVTQSAMNIVDNTEVQPEERSTYSFSFSDPRFWELPSV 
               
               
                   
                   
                 YGWLVGQTQAAPRTAPSPGALETASALGEVASVSPVRSE 
               
               
                   
                   
                 FMPGGMDQPRLGGRSGSGCRSSGSRMMRTAGLNDHPHDE 
               
               
                   
                   
                 NYPQSVVSKLRSELEASLAAAASTELPCTVKLRVWPYDM 
               
               
                   
                   
                 KDPCALFRSESCRLTIPHAVLCSEMGAHFSPCGRFFAAC 
               
               
                   
                   
                 VACVLPQLEADPVLHGQVDPDVTGVATSPTRHPVSAYQI 
               
               
                   
                   
                 MYELRIYSLEEATFGMVLASRSIRAAHCLTSIQFSPTSE 
               
               
                   
                   
                 HLLLAYGRRHNSLLKSIVIDGENTVPIYSILEVYRVSD M   
               
               
                   
                   
                 
                   ELVRVLPSAEDEVNVACFHPSVGGGLVYGTKEGKLRILQ 
                 
               
               
                   
                   
                 IDSSGGLNPKSTGFLDENMAEVPTYALEC 
               
               
                   
               
               
                 93 
                 The amino acid sequence of SEQ ID 
                 MGEGDLPRT EAGVLRGHEGAVLAARFNGDGNYCLSCGKD   
               
               
                   
                 359. The conserved G-protein beta 
                   RTIRLWN PHRGI HIKTYKSHGREVRDVHCTSDNSKLISC   
               
               
                   
                 WD-40 repeat domains are 
                   GGDRQIFYWD VSTGR VIRRFRGHDSEVNAVKFNDYASVV   
               
               
                   
                 underlined. 
                   VSAGYDRSVRAWD CRSHSTE PIQIINTFQDSVMSVCLTK   
               
               
                   
                   
                   TEIIGGSVDGTVRTFD IRIGR EISDDLGQPVNCISMSND   
               
               
                   
                   
                   GNCILASCLDSTLRLVD RSAGE LLQEYKGHTCKSYKLDC   
               
               
                   
                   
                   CLTNTDAHVAGGSEDGYVFFWD LVDAS VISKFRAHSSVV   
               
               
                   
                   
                   TSVSYHPKEDCMITASVDGTIKVWK T 
               
               
                   
               
               
                 94 
                 The amino acid sequence of SEQ ID 
                 MACIKGVGRSASVAMAPDGGYLATGTMAGTVDLSFSSSA 
               
               
                   
                 360. The conserved G-protein beta 
                 SLEIFGLDFQSDDRDLPLIAESPSSERFNRLSWGKNGSG 
               
               
                   
                 WD-40 repeat domains are 
                 SDEFSLGLIAGGLVDGTIGLWNPLSLIRSEAGD KAIVGH   
               
               
                   
                 underlined 
                   LSRHKGPVRGLEFNVIAPNLLASGADDGEICIWD LAAPR 
               
               
                   
                   
                 EPSHF PPLRGSGSAAQGEISFLSWNSKVQHILASTSYNG   
               
               
                   
                   
                   TTVVWD LKKQKPVISFSDSVRRRCSVLQWNPDLATQLVV 
               
               
                   
                   
                 ASDEDSSPTLRLWDMRNI MSPVKEFAGHTRGVIAMSWCP   
               
               
                   
                   
                   NDSSYLVTCAKDNRTICWD TVT GEIVCELPAGSNWNFDV   
               
               
                   
                   
                   HWYPKIPGVISASSFDGKIGIYN VEGCSRYGVRENEFGA 
               
               
                   
                   
                 ATLRAPKWFKRPVGASFGFGGKVVSFHTRSTGGPSVNSS 
               
               
                   
                   
                 EVFVHDIITEQTLVSRSSEFEAAIQSGDRPSLRALCEKK 
               
               
                   
                   
                 SQHCESTDDQETWGFLKVLLEDDGTARSKLLAHLGFDIP 
               
               
                   
                   
                 TETNDGSQEDLSQQVNALGLEDVTADKVVQEDNNESMVF 
               
               
                   
                   
                 PTDNGEDFFNNLPSPRADTPVSTSADGFPTVNAAVEPSQ 
               
               
                   
                   
                 DEVDGLEESSDPSFDDSVQRALVVGDYKAAVALCMSANK 
               
               
                   
                   
                 LADALVIAHVGGASLWESTRDKYLKMSRLPYLKVVFAMV 
               
               
                   
                   
                 NNDLQSLVDTRPLKFWKETLAILCSFAQGEEWAMLCNSL 
               
               
                   
                   
                 ASKLMAAGNMLAATLCFICAGNIDKTVEIWSRSLATEHD 
               
               
                   
                   
                 GMSYMDLLQDLMEKTIVLALASGQKQFSASVCKLVEKYA 
               
               
                   
                   
                 EILASQGLLTTAMDYLKLLGTDDLSPELAVLRDRIAFSV 
               
               
                   
                   
                 EAEKGANISAFNGSQDPRGAVYGVDQSNYGMVDTSQHYY 
               
               
                   
                   
                 PEAAQPQVPHTVPGSPYGENYQQPFGSSFGKGYNTPMQY 
               
               
                   
                   
                 QAPSQASMFVPSEPPQNAQPSFVPTPVTSQPTTRSQFIP 
               
               
                   
                   
                 APPLALRNPEQYQQPTLGSHLYPGSVNPTFQPLPHAPGP 
               
               
                   
                   
                 VAPVPPQVSSVPGQNMPQAVAPTQMRGFMPVTNPGVVQN 
               
               
                   
                   
                 PGPISMQPATPIESAAAQPVVSPAAPPPTVQTADTSNVP 
               
               
                   
                   
                 APQKPVIATL 
               
               
                   
               
               
                 95 
                 The amino acid sequence of SEQ ID 
                 MKERGKGAGRSVDERYTQWKSLVPVLYDWLANHNLVWPS 
               
               
                   
                 361. The conserved G-protein beta 
                 LSCRWGPQLEQATYKNRQRLYLSEQTDGSVPNTLVIANV 
               
               
                   
                 WD-40 repeat domains are 
                 EVVKPRVAAAEHISQFNEEARSPFVKKFKTIIHPGEVNR 
               
               
                   
                 underlined. 
                 IRELPQNSKIVATHTDSPDVLIWDVETQPNRHAVLGAST 
               
               
                   
                   
                 SRP DLILTGHKDNAEFALAMSPTEPFVLSGGKDRYVVLW   
               
               
                   
                   
                   S IQDHISTLAADPGSAKSPGSAGTNNKQSSKAAGGNDKT 
               
               
                   
                   
                 GDSPSIE PRGVYLGHGDTVEDVTFCPSSAQEFCSVGDDS   
               
               
                   
                   
                   CLILWD ARTGSSP AIKVEKAHHADLHCVDWNPHDVNLIL   
               
               
                   
                   
                   TGSADNTVRMFD RRNLTSGGVGS PVHTFEGHNAAVLCVQ   
               
               
                   
                   
                   WSPDKSSVFGSSAEDGILNIWD HEKIGRKIETVGSKVPN 
               
               
                   
                   
                 SPPG LFFRHAGHRDKVVDFHWNSSDPWTIVSVSDDGEST   
               
               
                   
                   
                   GGGGTLQIWR MIDLIYRPEEEVLAELDKFKSHILSCTS 
               
               
                   
               
               
                 96 
                 The amino acid sequence of SEQ ID 
                 MAKIAPGCEPVAGTLTPSKKREYRVTNRLQEGKRPLYAV 
               
               
                   
                 362. The conserved G-protein beta 
                 VFNFIDSRYFNVFATVGGNRVTVYQCLEGGVIAVL QSYI   
               
               
                   
                 WD-40 repeat domains are 
                   DEDKDESFYTVSWACNIDRTPFVVAGGINGIIRVID AGN 
               
               
                   
                 underlined and the Trp-Asp (WD) 
                 EK IHRSFVGHGDSINEIRTQPLNPSL IVSASKDESVRLW     
               
               
                   
                 repeats signature is in bold. 
                     N     V HTGICIL IFAGAGGHRNEVLSVDFHPSDKYRIASCGM   
               
               
                   
                   
                   DNTVKIWS MKEFWTYVEKSFTWTDLPSKFPTKYVQF PVF   
               
               
                   
                   
                   IAPVHSNYVDCNRWLGDFVLSKSVDNEIVLWE PKMKEQS 
               
               
                   
                   
                 PGEGSVD ILQKYPVPECDIWFIKFSCDFHYHSIAIGNRE   
               
               
                   
                   
                   GKIYVWE LQSS PPVLIAKLSHPQSKSPIRQTAMSFDGST   
               
               
                   
                   
                   ILSCCEDGTIWRWD AITASTS 
               
               
                   
               
               
                 97 
                 The amino acid sequence of SEQ ID 
                 MNTAMHFGAGWRSIAEMGYTMSRLEIEPESCEDEKSLDG 
               
               
                   
                 363. The conserved G-protein beta 
                 VGNSQGPNELPRCLDHELAHLTNLKSRPHEHLIRDFPGR 
               
               
                   
                 WD-40 repeat domains are 
                 RALPVSTVKMLAGRECNYSRRGRFSSADCCHMLSRYVPV 
               
               
                   
                 underlined. 
                 NGPSPLDQMNSRAYVSQFSADGSLFVAGFQGSHIRIYNV 
               
               
                   
                   
                 DKGWKCQKNILTKSLRWTITDTSLSPDQRYLVYASMSPI 
               
               
                   
                   
                 VHIVDIGSAAMDSLANITEIHEGLD FSADSGPYSFGIFS   
               
               
                   
                   
                   VKFSTDGREVVAGSSDDSIYVYD LVANK LSLRIPAHESD   
               
               
                   
                   
                   VNTVCFADESGHIIYSGSDDTYCKVWD RRCLSARNK PAG   
               
               
                   
                   
                   VLMGHLEGITFIDSRGDGRYFISNGKDQTIKLWD IRKMG 
               
               
                   
                   
                 SDICRRGFRNFEWDYRWMDYPPRARDSKHPFDL SVATYK   
               
               
                   
                   
                   GHSVLRTLIRCYFSPVHSTGQKYIYTGSHDSCVYIYD VV 
               
               
                   
                   
                 TGA QVAALKHHKSPVRDCSWHPEYPMIVSSSWDGDIVKW   
               
               
                   
                   
                   E FFGNGETEIPAMKKRIRRRHLY 
               
               
                   
               
               
                 98 
                 The amino acid sequence of SEQ ID 
                 MEPQPQAPKKRGRKPKPKEDKKEEQLHQPPPPPPPQQQA 
               
               
                   
                 364. The conserved G-protein beta 
                 APAPAPAATRSSTSGSAGGRDRRPQQQHAVDEKYARWKS 
               
               
                   
                 WD-40 repeat domains are 
                 LVPVLYDWLANHNLLWPSLSCRWGPQLEQATYKNRQRLY 
               
               
                   
                 underlined. 
                 ISEQTDGSVPNTLVIANCEVVKPRVAAAEHVSQFNEEAR 
               
               
                   
                   
                 SPFIRKYKTIIHPGEVNRVRELPQNPNIVATHTDSPDVL 
               
               
                   
                   
                 IWDVESQPNRHAVYGATASRPNLILTGHQENAEFALAMC 
               
               
                   
                   
                 PAEPFVLSGGKDKTVVLWSIQDHITASATDQTTNKSPGS 
               
               
                   
                   
                 GGSIIKKTGEGNEETGNGPS VGPRGIYCGHEDTVEDVAF   
               
               
                   
                   
                   CPSTAQEFCSVGDDSCLILWD ARVGT NPVAKVEKAHNGD   
               
               
                   
                   
                   LHCVDWNPHDNNLILTGSADNSVNMFD RRNLTSNGV GSP   
               
               
                   
                   
                   VYKFEGHKAAVLCVQWSPDKPSVFGSSAEDGLLNIWD YE 
               
               
                   
                   
                 RVDKKVDRAPNAPAGLFFQHAGHRDKIVDFHWNAADPWT 
               
               
                   
                   
                 MVSVSDDCDTAGGGGTLQIWRMSDLIYRPEEEVLAELEN 
               
               
                   
                   
                 FKAHVLECSKA 
               
               
                   
               
               
                 99 
                 The amino acid sequence of SEQ ID 
                 MGIFEPYRAVGYITTGVPFSVQRLGTETFVTVSVGKAFQ 
               
               
                   
                 365. The conserved G-protein beta 
                 VYNCAKLSLVLVGPQLPKKIRALASYREYTFAAYGSDIG 
               
               
                   
                 WD-40 repeat domains are 
                 IFKRAHQLATWSGHTAKVCLLLLFGEHILSVDVDGNAYI 
               
               
                   
                 underlined and the Trp-Asp (WD) 
                 WAFKGMNYNLSPVGHILLDSNFTPSCIMHPDTYLNKVIL 
               
               
                   
                 repeats signature is in bold. The 
                 GSQEGPLQLWNISTKTKLYEFKGWNSSVSSCVSSPALDV 
               
               
                   
                 Utp21 specific WD40 associated 
                 VAVGCADGKIHVHNIRYD EELVTFSHSMRGSVTALSFST   
               
               
                   
                 putative domain is in italics. 
                   DGQPLLASGSSSGVVSIWN LDKRRLQSVIRDAHDGSIIS 
               
               
                   
                   
                 LHFFANEPVLMSSSADNSIKMWIFDTSDGDPRLLRFRSG 
               
               
                   
                   
                 HSAPPLCIRFYANGRHILSAGQDRAFRLFSVVQDQQSRE 
               
               
                   
                   
                 LSQRHVSKRAKKLKLKEEEIKLKPVIAFDVAEIRERDWC 
               
               
                   
                   
                 NVVTSHMDTPQAYVWRLQNFVIGEHILRPCPNKPTPVKA 
               
               
                   
                   
                 CMISACGNFAILGTAGGWIERFNLQSGISRGSYIDQLEG 
               
               
                   
                   
                 TNSAHDGEVVGVACDATNTLMISAGYAGDIKVWDFKGRE 
               
               
                   
                   
                 LKSRWEIGSSLVKISYHRLNGLLATVADDFIIRLFDAVA 
               
               
                   
                   
                 
                   LRMVRKFEGHTDRITDLCFSEDGKW LLSSSMDGSLRIWD   
                 
               
               
                   
                   
                   I ILARQVDAVFVDVSITALSLSPNMDILATTHVDQNGVF 
               
               
                   
                   
                 LWVNQSMFSGDSDINLYASGKEVVTVKLPSVSSVEGS QV   
               
               
                   
                   
                 
                   EESNEPTIRHSESKDVPSFRPSLEQIPDLVTLSLLPKSQ 
                 
               
               
                   
                   
                 
                   WQSLINLDIIKVRNKPVEPPKKPEKAPFFLPSIPSLSGE 
                 
               
               
                   
                   
                 
                   ILFKPSEMSDKGDMKADEDKSKITPEVPSSRFLQLLHSC 
                 
               
               
                   
                   
                 
                   SEAKNFSPFTTYIKGLSPSTLDLELRMLQIIDDDAVDAD 
                 
               
               
                   
                   
                 
                   ADDPQDVDKRQELLSIELLMDYFIHEISCRSNFEFVQAL 
                 
               
               
                   
                   
                 
                   VRLFLKIHGETIRRQSVLQNKAKVLLETQCSVWQRVDKL 
                 
               
               
                   
                   
                   FQGARCMVAFLSNS QF 
               
               
                   
               
               
                 100 
                 The amino acid sequence of SEQ ID 
                 MEETKVTCGSWIRRPENVNLAVLGRSPRRRGSAALEIFA 
               
               
                   
                 366. The conserved G-protein beta 
                 FDPKSTSLSSSPLVAHVIEEIEGDPLAIAVHPNGEDIVC 
               
               
                   
                 WD-40 repeat domains are 
                 FASSGSCLSFELSGQESNLKLLTK ELPPLRGIGPQKCMA   
               
               
                   
                 underlined. 
                   FSVDGSRFATGGVDGRLRILE WPSLRI ILDEPKAHKSIR   
               
               
                   
                   
                   DLDFSLDSEFLATTSTDGSARIWK AEDGLPCTTLTRRSD 
               
               
                   
                   
                 EKIELCRFSKDGTKPFLFCTVQRGDKAVTGVWDISTWNK 
               
               
                   
                   
                 IG HKRLLRKPAVVMSISLDGKYLAQGSKDGDMCVVE VKK 
               
               
                   
                   
                 MEVSHWSKRLHLGTSLTSLEFCPIERVVITTSDEWGVLV 
               
               
                   
                   
                 TKLNVPADWKAWQVYLLLLGLFLASLVAFYIFYENSDSF 
               
               
                   
                   
                 WGFPLGKDQPARPKIGSVLGDPKSADDQNMWGEFGPLDM 
               
               
                   
               
               
                 101 
                 The amino acid sequence of SEQ ID 
                 MADPVEHQHQQHQQHQLQQQRRRGWRIQGGQYLGEISAL 
               
               
                   
                 367. The conserved G-protein beta 
                 CFLHLPPPPLSLSSSPVLSLSSGLDSESRDRPACSFRFP 
               
               
                   
                 WD-40 repeat domains are 
                 SAGSGSQVSLFDLASGAMVRTFYVFRGIRVHGIVLGCAD 
               
               
                   
                 underlined. 
                 FPGGSSSSSSTLDYVIAVYGERRVKLFRLSVRLGRGAGE 
               
               
                   
                   
                 GSGTVLSADLELVSAAPRLSHWVMDVRFLKENGTSEDEL 
               
               
                   
                   
                 QRCLTVAIGCSDNSIRLWDVDKCSFVLAVSSPERCLLYS 
               
               
                   
                   
                 MRLWGDNLEDLQVASGTIYNEILIWKVVPNHDAPSSNEL 
               
               
                   
                   
                 TEEGLTNSCAGNSVHECLRYE AYHICRLVGHEGSIFRIA   
               
               
                   
                   
                   WSSDGSKLVSVSDDRSARIWE VHCKVQYSEDA GEVGLLF   
               
               
                   
                   
                   GHSARVWDCYISDNLIVTAGEDCSCRVWG LDGQQHDVIK 
               
               
                   
                   
                 EHIGRGIWRCLYDPWSSLLVTGGFDSAIKVHKLDASLAE 
               
               
                   
                   
                 ASAKQSNIKDLSDGTELFTTHLPNSSGHSGHMDSKSEYV 
               
               
                   
                   
                 RCLSFSCEDVMYIATNHGYLYHAKLCNDGDLRWTELAQV 
               
               
                   
                   
                 SNEVQIICMELLPSNPYDPRIDADDWVAVGDGKGWTTVV 
               
               
                   
                   
                 RVVKNSDSPKVSTSFSWAAEMDRQLLGIHWCKSLGHRFI 
               
               
                   
                   
                 FTADPRGALKLWRFFEVSQSSSLYPENSPRISLIAEFKS 
               
               
                   
                   
                 DLGARIMCLDVAFESELLICGDLRGNLVLFPLLKDLLLD 
               
               
                   
                   
                 TFVVSAAKISPVNHFKGAHGISAVSSISVAHMSFNHIEL 
               
               
                   
                   
                 RSTGADGCICYMEYDKGLQSLNFVGMKQVKELSMIESVS 
               
               
                   
                   
                 TENESTGYRTSGSYASGFASTDFIIWNLVTEAKVLQVSC 
               
               
                   
                   
                 GGWRRPHSYYLGDVPEMKNCFAYVKDDIIYIRRHWIKDS 
               
               
                   
                   
                 KDKILPQNLRLQFHGREVHSLCFVTGDFQLRKNKQSSWI 
               
               
                   
                   
                 VTGCEDGTVRLTRYTQCTDNWSSSKLLGEHVGGSAVRSI 
               
               
                   
                   
                 CCVSNIHTTSSGTSVSDVKGIENLPKDIKGTLMEDECNP 
               
               
                   
                   
                 SLLISVGAKRVLTSWLLRRRKQDGKEDDVTDLQEAENSS 
               
               
                   
                   
                 LPSSAGSSTFSFQWLSTDMPVKYSVPSKKSGSIKKLIGV 
               
               
                   
                   
                 SDTNVRCKSL 
               
               
                   
               
               
                 102 
                 The amino acid sequence of SEQ ID 
                 MPYK LSATLSNHSSDVRAVASPSDDLILSASRDSTAISW   
               
               
                   
                 368. The conserved G-protein beta 
                   F RQSPSSFT PASVIRAGSRFVNAIAYLPPTPRAPQGYAV   
               
               
                   
                 WD-40 repeat domains are 
                   VGGQDTVVNVFA LGPGDKEE PEYTLVGHTDNVCALSVNS   
               
               
                   
                 underlined. 
                   DDTIISGSWDKTAKVWK DFA LVYDLKGHQQSVWAVLAMN   
               
               
                   
                   
                   EKEFLTASADRTIKYWV QHK TMQTYEGHRDAVRGLALIP   
               
               
                   
                   
                   DIGFASCSNDSEIRVWT MGGD VVYTLSGHTSFVYSLSVL   
               
               
                   
                   
                   PNGDLVSAGEDRSVRVWR DGE CSQVIVHPAISVWAVSTM   
               
               
                   
                   
                   PNGDIISGSSDGVVRVFS ESEKRWATASELKALEDQIAS 
               
               
                   
                   
                 QSLPSQQVGDVKKTDLPGPEALSVPGKKAGEVKMIRSGD 
               
               
                   
                   
                 VVEAHQWDSLASSWQKIGEVVDAIGSGRKQLHDGKEYDY 
               
               
                   
                   
                 VFDVDIQEGAPPLKLPYNVSENPYTAAQRFLEQNDLPTG 
               
               
                   
                   
                 YLDQVVKFIEQNTAGVKLGNDGYVDPFTGASRYQPATQS 
               
               
                   
                   
                 TSNTASSSYMDPFTGGSRHIAESAPSNVPQGSHATGIIP 
               
               
                   
                   
                 FSKPIFFKLANVSAMQAKMFQFDEVLRNEISTATLAMRP 
               
               
                   
                   
                 DEVIMVNETFTYLSKVVTSTSSARTSLGWIHIETIMQIL 
               
               
                   
                   
                 DRWPVPQRFPVIDLGRLVTAYCMNAFSGPGDLEKFFSCL 
               
               
                   
                   
                 FRTSEWTSITSGSKALTKAQETNVLLLFRTIANSLDGAP 
               
               
                   
                   
                 LNDMEWIKQIFRELAQTPQLVLNKSHRLALASVLFNFSC 
               
               
                   
                   
                 IGLKGPVPADVRTLHLTIILQVLRSPNDDPEVAYRTCVA 
               
               
                   
                   
                 LGNMLYSDKTRGTPRDAQSPSPTELKSAVAAIKGGFSDP 
               
               
                   
                   
                 RINDVHREIMSLI 
               
               
                   
               
               
                 103 
                 The amino acid sequence of SEQ ID 
                 
                   
                     MPPQKIESGHKDTVHDLAMDYYGKRLATASSDHTINVVG 
                   
                 
               
               
                   
                 369. The conserved G-protein beta 
                 
                   VSSSG SQHLATLIGHQGPVWQISWAHPKFGSLLASCSYD   
                 
               
               
                   
                 domain is underlined and the WD-40 
                 
                     GRVIIWR EGNPNE WTQAQVFEEHKSSVNSVAWAPHELGL   
                 
               
               
                   
                 repeat domains are in bold 
                 
                     CLACGSSDGNISVFT ARQDGG WDTSRIDQAHPVGVTSVS   
                 
               
               
                   
                   
                 
                     WAPSTAPGALVGSGMMEPVQKLCSGGCDNTVKVWK LYNR 
                 
               
               
                   
                   
                 
                   VWK LDCFPVLQMHTDWVRDVAWAPNLGLPKSTIASASQD   
                 
               
               
                   
                   
                 
                     GRVIIWT LAKEGD QWQGKVLYDFRTPVWRVSWSLTGNIL   
                 
               
               
                   
                   
                     AVADGNNNVSLWN   EAVDGEWIQVSTVEP 
               
               
                   
               
               
                 104 
                 The amino acid sequence of SEQ ID 
                 MSAPMLEIEARDVVKIVLQFCKENSLHQTFQTLQSECQV 
               
               
                   
                 370. The conserved G-protein beta 
                 SLNTVDSIETFVADINSGRWDAILPQVAQLKLPRNTLED 
               
               
                   
                 WD-40 repeat domains are 
                 LYEQIVLEMIELRELDTARAILRQTQAMGVMKQEQPERY 
               
               
                   
                 underlined and the Trp-Asp (WD) 
                 LRLEHLLVRTYFDPNEAYQDSTKEKRRAQIAQALAAEVT 
               
               
                   
                 repeats signature is in bold. 
                 VVPPSRLMALVGQALKWQQHQGLLPPGTQFDLFRGTAAM 
               
               
                   
                   
                 KQDVDDMY PTTLSHTIKFGTKSHAECARFSPDGQFLVSC   
               
               
                   
                   
                   SVDGFIEVWD YMSGKLKKDLQ YQADETFMMHDDPVLCVD   
               
               
                   
                   
                   FSRDSEMLASGSQDGKIKVWR IR TGQCLRRLERAHSQGV   
               
               
                   
                   
                   TSVLFSRDGSQLLSTSFDGSARIHG LK SGKQLKEFRGHS   
               
               
                   
                   
                   SYVNDAIFSNDGSR VITASSDCTVKVWD     V K TSDCLQTFK   
               
               
                   
                   
                   PPPPLRGGDASVNSVHLFPKNADHIVVCNKTSSIYIMT L 
               
               
                   
                   
                 
                   QGQVVKSLSSGKREGGDFVAACVSPKGEWIYCVGEDRNL 
                 
               
               
                   
                   
                   YCFS CQ SGKLEHLMKVHEKDVIGVTHHPHRNLVATYSED   
               
               
                   
                   
                   STMKLWK P 
               
               
                   
               
               
                 105 
                 The amino acid sequence of SEQ ID 
                 MDLLQSYAEDNDGDLGRHSSPEPSPPRLLPSKSAAPKVD 
               
               
                   
                 371. The conserved G-protein beta 
                 DTTLALTVAQTNQTLARPIDPSQHAVAFNPTYDQLWAPI 
               
               
                   
                 WD-40 repeat domains are 
                 CGPAHPYAKDGIAQGMRNHKLGFVEDAAIGSFLFDEQYN 
               
               
                   
                 underlined. 
                 TFQRYGYAADPCASTGNEYVGDLDALKQNDGISVYNIRQ 
               
               
                   
                   
                 QEQKKYAEEYAKKKGEERGEGGREKAEVVSDKSTFHGKE 
               
               
                   
                   
                 ERDYQGRSWIAPPKDAKATNDHCYIPKR LVHTWSGHTKG   
               
               
                   
                   
                   VSAIRFFPKHGHLILSAGMDTKVKIWD VFNSGK CMRTYM   
               
               
                   
                   
                   GHSKAVRDISFCNDGTKFLTAGYDKNIKYWD TETGK VIS   
               
               
                   
                   
                   TFSTGKIPYVVKLHPDDEKQNILLAGMSDKKIVQWD MNT 
               
               
                   
                   
                 GQ ITQEYDQHLGAVNTITFVDDNRRFVTSSDDKSLRVWE   
               
               
                   
                   
                 FGIPVV IKYISEPHMHSMPSISLHPNTNWLAAQSLDNQI   
               
               
                   
                   
                   LIYS TRERFQLN KKKRFAGHIVAGYACQVNFSPDGRFVM   
               
               
                   
                   
                   SGDGEGRCWFWD WKSCK VFRTLKCHEGVCIGCEWHPLEQ   
               
               
                   
                   
                 
                   SKVATCGWDGLIKYWD 
                 
               
               
                   
               
               
                 106 
                 The amino acid sequence of SEQ ID 
                 MESNGNLEQTLQDGRIYRQLNSLIVAHLRDHNFPQAASA 
               
               
                   
                 372. The conserved G-protein beta 
                 VALATMTPLNVEAPRNRLLELVAKGLAVEKGELLRGVSH 
               
               
                   
                 WD-40 repeat domains are 
                 AGTNDLGGSIPASYGLVPAPWTAIDFSSLRDTKGMSKSF 
               
               
                   
                 underlined. 
                 
                   TKHETRHLSDHKNVARCARFSTDGRFFATGSADTSIKLF 
                 
               
               
                   
                   
                   E VSKIKQMMLPDSTDGA IRAVIRTFYDHTHPVNDLDFHP   
               
               
                   
                   
                   QNTVLISAAKDHTVKFFD YSKAT AKRAFRVIQDTHNVRS   
               
               
                   
                   
                   VAFHPSGDFLLAGTDHPIPHLYD VN TFQCYLSANVPEFA   
               
               
                   
                   
                   VNAAINQVRYSSSGGMYVTASKDGTIRFWD GA SANCVRS   
               
               
                   
                   
                   IAGAHGAAEVTSANFTKDQRYVLSCGKDSTVKLWE VGTG 
               
               
                   
                   
                 RLVKQYLGATHMQLRCQAVFNNTEEFVLSIDEPSNEIVV 
               
               
                   
                   
                 WDAM TAEKVARWPSNHNGPPRWIEHSPTEAAFVSCSTDR   
               
               
                   
                   
                   SIRFWK ETH 
               
               
                   
               
               
                 107 
                 The amino acid sequence of SEQ ID 
                 MSNFQGEDGEYVADDFEAEDGDEELHGRESADPESDVDE 
               
               
                   
                 373. The conserved G-protein beta 
                 IDTPSNRFTDTTADQARRGRDIQGIPWERLSITREKYRR 
               
               
                   
                 WD-40 repeat domains are 
                 TRLEQYKNYENVPQSGEKSGKDCTVTEKGNSFYEFRRNS 
               
               
                   
                 underlined. 
                 RSVKSTILHFQLRNLVWATSKHDVYLMSNYSVVHWSSLT 
               
               
                   
                   
                 GKKSEVLNLAGHVAPNEKHPGSLLEGFTQTQVSTLAVKD 
               
               
                   
                   
                 RFLVAGGFQGELICKFLDRPGISFCSRTTYDDNAITNAV 
               
               
                   
                   
                 EIYVSPSGGIHFIASNNDCGVRDFDME NFELSKHFRFPW   
               
               
                   
                   
                   PVNHTSLSPDGKLLVIVGDDPEGILVD AK TGKTIMPLRG   
               
               
                   
                   
                   HLDFSFASEWHPDGVTFATGNQDKTCRIWD IRN LSKSIA   
               
               
                   
                   
                   VLKGNLGAIRSIRYTSDGRYMAIAEPADFVHVYD TKTGY 
               
               
                   
                   
                 KKEQEIDFFGEISGMSFSPDTESLFIGVWDRTYGSLLEY 
               
               
                   
                   
                 GRRRNFSYLDCLV 
               
               
                   
               
               
                 108 
                 The amino acid sequence of SEQ ID 
                 MGVEEDLEDLNALAESTDAAVDGQAALASAVDSVTLQPA 
               
               
                   
                 374. The conserved G-protein beta 
                 PPILPPVIPPPAVPVVAPVPTIPPVLRPLAPLPIRPPVL 
               
               
                   
                 WD-40 repeat domains are 
                 RPPAPKRDEAGSSDSDSDHDGTAAGSTAEYEITEESRLV 
               
               
                   
                 underlined and the splicing factor 
                 RERHEKAMQDLMMKRRGAALAVP TNDKAVRARLRRLGEP   
               
               
                   
                 motif is in bold. 
                   MTLFGEREMERRDRLRMLMAKLDAEGQLEKLMKAHEDE E 
               
               
                   
                   
                 AAASAAPEDVEEEMLQYPFYTEGSKALFNARIDIAKFSI 
               
               
                   
                   
                 TRAALRLERARRRRDDPDEDVDAEIDWALKKAESLSLHC 
               
               
                   
                   
                 SEIGDDRPLSGCSFSHDGKLLATCSMSGVAKLWDTCRMP 
               
               
                   
                   
                 QVNRVLTLKGHTERATDVAFSPVQNH IATASADRTAKLW   
               
               
                   
                   
                   NT EGTILKTFEGHLDRLGRIAFHPSGKY LGTTSFDKTWR   
               
               
                   
                   
                   LWDI ESGEELLLQEGHSRSIYGIDFHRDGSLVASCGLDA 
               
               
                   
                   
                 LARVWDLRTGRSILALEGHVKPVLGVSFSPNGYH LATGG   
               
               
                   
                   
                   EDNTCRIWDL RKKKSLYTIPAHANLISEVKFEPQEGYFL 
               
               
                   
                   
                 VTASYDTTAKVWSARDFKPVKTLSVHEAKITSVDITADA 
               
               
                   
                   
                 SHIVTVSHDRTIKLWTSNDDVKEQAMDVD 
               
               
                   
               
               
                 109 
                 The amino acid sequence of SEQ ID 
                 MVKAYLRYEPAAAFGVIASVESNIAYDASGKHLLAPALE 
               
               
                   
                 375. The conserved G-protein beta 
                 KVGVWHVRQGVCTKALAPSASSAAGPSLAVTAIASSPSS 
               
               
                   
                 WD-40 repeat domains are 
                 L IASGYADGSIRIWDF EKGSCETTLNGHKGAVSVLRYGK 
               
               
                   
                 underlined, and the conserved 
                 LGSL LASGSKDNDIILWDV VGETGLYRLRGHRDQVTDLV 
               
               
                   
                 Dip2/Utp12 domain is in bold. 
                 FLDSDKK LVSSSKDKYLRVWDL ETQHCMQIVGGHHSEIW 
               
               
                   
                   
                 SLDTDPEERYLVTGSADPELRFYTVKNDSSDERSEADAS 
               
               
                   
                   
                 GGVGNGDLASHNKWDVLKQFGEIQRQSKDRVATVRFNKN 
               
               
                   
                   
                 GNLLACQAAGKLVEVFRVLDEAEAKRKAKRRLHRKREKK 
               
               
                   
                   
                 GADVNENSDSSRGIGEGHDTMVTVADVFKLLQTIRASKK 
               
               
                   
                   
                 ICSISFCPVAPKSSLATLALSLNNNLLEFHSIEADKTSK 
               
               
                   
                   
                 MLTIELQGHRSDVRSVTLSSDNTLLMSTSHNSVKIWNPS 
               
               
                   
                   
                 TGSCLRTIDSGYGLCGLIVPQNKHALIGTKDGAIEIFDV 
               
               
                   
                   
                 GSGTCIEVVEAHGGSIRSIVAIPNQNGFVTGSADHDIKF 
               
               
                   
                   
                 WEYGMKQKPGDNSKHLTVSNVRTLKMNDDVLVVAVSPDA 
               
               
                   
                   
                 QKIAVALLDCTVKVFFMDSLKLMHSLYGHRLPVLCLDIS 
               
               
                   
                   
                 SDGDLIVTGSADKNLMIWGLDFGDRHKSIFAHGDSIMAV 
               
               
                   
                   
                 QFVGNTHYMFSVGKDRLVKYWDADKFELLLTLEGHHADI 
               
               
                   
                   
                 WCLAISNRGDFLVTGSHDRSIRRWDRTEEPFFIEEEKEK 
               
               
                   
                   
                 RLE EMFESDLDNAFGNKYVPKEEIPEEGAVALAGKKTQE   
               
               
                   
                   
                 
                   TLSATDSIIEALDIAEVELKRIAEHEEEKNNGKTAEFHP 
                 
               
               
                   
                   
                 
                   NYVMLGLSPSDFILRALSNVQTNDLEQTLLALPFSDALK 
                 
               
               
                   
                   
                 
                   LLSYLKDWTTYPDKVELVSRIATVLLQTHYNQLVSTPAA 
                 
               
               
                   
                   
                 
                   RPLLTTLKDILHKKVKECKDTIGFNLAAMDHLKQLMALR 
                 
               
               
                   
                   
                 
                   SDALFQDAKVKLLEIRSQLSKRLEERTDPREAKRRKKKQ 
                 
               
               
                   
                   
                   KKS TNMHAWP 
               
               
                   
               
               
                 110 
                 The amino acid sequence of SEQ ID 
                 MGGVQAEREDKDKVSLELTEEILQ SMEVGMTFRDYSGRI   
               
               
                   
                 376. The conserved G-protein beta 
                   SSMDFHRASSYLVTASDDESIRLYD VASATCLKTINSKK 
               
               
                   
                 WD-40 repeat domains are 
                 YSVDLVSFTSHPMTVIYSSKNGWDESLRLLSLH DNKYLR   
               
               
                   
                 underlined. 
                   YFKGHHDRVVSLSLCPRNECFISGSLDRTVLLWD QRAEK 
               
               
                   
                   
                 CQGLLRVQGRPATAYDDPGLVFAIAFGGCVRMFDARKYE 
               
               
                   
                   
                 K GPFEIFSVGGDVSDANVVKFSNDGRLMLLTTTDGHIHV   
               
               
                   
                   
                   LD SF RGTLLYTFNVKPTSSKSTLEASFSPEGMFVISGSG   
               
               
                   
                   
                   DGSVYAWS VRGGKEVASWLSTDTEPPVIKWAPGNLMFAT 
               
               
                   
                   
                 GSSELSFWIPDLSKLGAYVGRK 
               
               
                   
               
               
                 111 
                 The amino acid sequence of SEQ ID 
                 MAAFGAAPAGNHN PNKSSEVIQPPSDSVSSLCFSPRANH   
               
               
                   
                 377. The conserved G-protein beta 
                   LVATSWDNQVRCWE LTKNGASV TSVPKASMSHDQPVLCS   
               
               
                   
                 WD-40 repeat domains are 
                   AWKDDGTTVFSGGCDKQAKMWS LMS GGQPVTVAMHDAPI   
               
               
                   
                 underlined. 
                   KEIAWIPEMNVLVTGSWDKTLKYWD TRQSNPVHTQQLPE 
               
               
                   
                   
                 RCYAMTVRYPLMVVGTADRNLIVFN LQNPQAEFKRFSSP   
               
               
                   
                   
                   LKYQTRCVAAFPDQQGFLVGSIEGRVGVHH LDDS QISKN   
               
               
                   
                   
                 
                   FTFKCHRDNNDIYSVNSLNFHPVHHTFATAGSDGTFNFW 
                 
               
               
                   
                   
                   D KDSKQRLKAMSRCSQPIPCSTFNNDGTIYAYSVCYDWS 
               
               
                   
                   
                 KGAENHNPATAKTYIFLHLPQESEVKAKPRVGTTNRK 
               
               
                   
               
               
                 112 
                 The amino acid sequence of SEQ ID 
                 MNCSISGEVPEEPVVSTKSGHVFERRLIERYVSDYGKCP 
               
               
                   
                 378. The conserved G-protein beta 
                 VSGEPLTMDDVLPVKMGKIVKPRPLQAASIPGLLSIFQN 
               
               
                   
                 WD-40 repeat domains are 
                 EWDSLMLSNFALEQQLHTARQELSHALYQHDAACRVIAR 
               
               
                   
                 underlined. 
                 LKKERDEARSLLALAERQIPMTASSDIAVNAPAMSNGRK 
               
               
                   
                   
                 ASLDEEPGYAGKKMRPGISASIIAEITDCNLALSQQRKK 
               
               
                   
                   
                 RQIPSTLAPVEDLE RYTQLSSYPLHKTGKPGITSLDICH   
               
               
                   
                   
                   SKDIIATGGIDTSAVLFD RS SGQIMSTLSGHSKKVTSVN   
               
               
                   
                   
                   FDAQGDMVLTGSADKTVRIWQ GSEDG SYNCRHILKDHTA   
               
               
                   
                   
                   EVQAITVHATNNYFATASLDNTWCFYE FS TGLCLTQVEG   
               
               
                   
                   
                   ASGSEGYTSAAFHPDGLILGTGTSNADVKIWD VK TQANV   
               
               
                   
                   
                   TTFSGHTGAITAISFSENGYFLATAAQDGVKLWD LR KLK   
               
               
                   
                   
                   NFRTFSAYDKDTGTNSVEFDHSGCYLGLAGSDIRVYQ VA 
               
               
                   
                   
                 SVKS EWNCVKTFPDLSGTGKVTCVKFGPDSKYIAVGSMD   
               
               
                   
                   
                   HNLRIFG LPSEDGAMES 
               
               
                   
               
               
                 113 
                 The amino acid sequence of SEQ ID 
                 MAAPGVETLKKEIKELKEKIAQHRLDTDGEQPLPAAAKS 
               
               
                   
                 379. The conserved G-protein beta 
                 KSVPEVSAALKQRRI   LKGHFGKIYALHWSADSRHLVSAS     
               
               
                   
                 domain is underlined and the WD-40 
                 
                     QDGKLIIWN GFT TNKVHAIPLRSSWVMTCAYSPSGNLVA   
                 
               
               
                   
                 repeat domains are in bold 
                 
                     CGGLDNLCSVYK VPHGGNKESSSA QKTYGELAQHEGYLS   
                 
               
               
                   
                   
                 
                     CCRFIKDNEIVTSSGDSTCILWD VET KTPKAIFNDHTGD   
                 
               
               
                   
                   
                 
                     VMSLAVFDDKGVFVSGSCDATAKLWD HRVH KQCVMTFQG   
                 
               
               
                   
                   
                 
                     HESDINSVQFFPDGDAFGTGSDDSSCRLFD IRAYQ QINK   
                 
               
               
                   
                   
                 
                     YSSDKILCGITSVAFSKTGKSLFAGYDDYNTYVWD TLS G   
                 
               
               
                   
                   
                 
                   
                     NQVEVLTGHENRVSCLGVSEDGKALATGSWDTLLKIWA 
                   
                 
               
               
                   
               
               
                 114 
                 The amino acid sequence of SEQ ID 
                 MGGVEDESEPASKRMKLSSRVLRGLANGSSRTEPAAGSS 
               
               
                   
                 380. The conserved G-protein beta 
                 LDLMARPLPIEGDEEVIGSKGVIKRVEFVRLIAKALYSL 
               
               
                   
                 WD-40 repeat domains are 
                 GYEKSGARLEEESGIPLQSSVVNLFMQQISDGLWDESVV 
               
               
                   
                 underlined. 
                 TLHKIGLSDENLVKSASFLILEQKFLELLDQEKAMDALK 
               
               
                   
                   
                 TLRTEITPLCIKNSRVRELSSCIISPSSCGLLNQNKRNS 
               
               
                   
                   
                 TRARSRSELLEELQKLLPPAVIIPERRLEHLVEQALVLQ 
               
               
                   
                   
                 TDACMLHNSIDMEMSLYTDHQCGKEHI PCRTLQILQSHN   
               
               
                   
                   
                   DEVWLVQFSHNGKYLASASNDRSAIIWE VDENG SVSLKH   
               
               
                   
                   
                   KLTGHQKPISSVCWSPDDRQLLTCGVGETVRRWD VS SGE   
               
               
                   
                   
                   CLRVYEKAGHGLISCAWFPDGKWICYGVSDRSICMCD L E   
               
               
                   
                   
                 
                   GKEIECWKGQRTLSISDLEITSDGKQIISICRETAILLL 
                 
               
               
                   
                   
                   D R EAKYERMIEENQTITSFSLSKDNRYLLVNLLNQEIHL   
               
               
                   
                   
                   WD IKG DFRLVAKYKGLKRSRFVIRSCFGGLKQAFVASGS   
               
               
                   
                   
                   EDSQVYIWH KG SGELIEPLPGHSGAVNCVSWNPANHHML   
               
               
                   
                   
                   ASASDDRTIRIWG LNELNTRHKGARPNGVHYCNGNGTS 
               
               
                   
               
               
                 115 
                 The amino acid sequence of SEQ ID 
                 MTQLAETYACMPSTERGRGILIAGNPKPGSNSVLYTNGR 
               
               
                   
                 381. The conserved G-protein beta 
                 SVVILNLD NPLDISVYAEHAYPATVARFSPNGEWVASAD   
               
               
                   
                 WD-40 repeat domains are 
                   SSGAVRIWG AYNDHVLKKEFKVLSGRIDDLQWSPDGLRI 
               
               
                   
                 underlined. 
                 VASGDGKGKSLVRAFMWD SGTNVGEFDGHSRRVLSCAFK   
               
               
                   
                   
                   PTRPFRIVTCGEDFLVNFYE GP PFKFKLSRRDHSNFVNC   
               
               
                   
                   
                   LRFSPDGNRFISVSSDKKGIIYD GK TGEKIGELSSDGGH   
               
               
                   
                   
                   TGSIYAVSWSPDSKQVITVSADKSAKIWD ISEDGSGNLR 
               
               
                   
                   
                 KTLTSSGSGGVDDMLVGCLWQNNHLVTVSLGGTISIYTA 
               
               
                   
                   
                 GD LDKAPVSFSGHMKNVSSLSVLKGDPKVILSSSYDGLI   
               
               
                   
                   
                   IKWI QGIGFSGRVQRKESTQIKCLAAVDEEIVTSGYDNK 
               
               
                   
                   
                 VCRVSGSGDAEFIDIGCQPKDLSLALQCPEFALVSTDTG 
               
               
                   
                   
                 VVLLR GAKIVSTINLGFAVTASTVAPDGTEAIIGAQDGK   
               
               
                   
                   
                   LRIYS ISGD TLTEEAVLEKHRGAISVIHYSPDLSMFASG   
               
               
                   
                   
                   DLNREAVVWD RASR EVRLKNILYHTARINCLAWSPDSST   
               
               
                   
                   
                   VATGSLDTCVIIYE VDK PASNRLTIKGAHLGGVYGLAFT   
               
               
                   
                   
                   DDFSVVSSGEDACIRVWK INRQ 
               
               
                   
               
               
                 116 
                 The amino acid sequence of SEQ ID 
                 MKVKVISRSTDEFTRERSQDLQRVFRNFDPNLRTQEKAV 
               
               
                   
                 382. The conserved G-protein beta 
                 EYVRALNAAKLDKVFA RPFVGAMDGHVDSVSCMAKNPNY   
               
               
                   
                 WD-40 repeat domains are 
                   LKGIFSGSMDGDIRLWD IAS RRTVCQFPGHQGPVRGLAA   
               
               
                   
                 underlined and the SOF1 protein 
                   STDGQILVSCGIDSTVRLWN VPVATLGESDGTHENLAKP 
               
               
                   
                 domain is in bold. 
                 LAVYVWKNAFWAVDHQWDGELFATAGAQVDIWNQNR SQP   
               
               
                   
                   
                   ISSFEWGTDTVISVRFNPGEPNVLATSGSDRSITLYD LR 
               
               
                   
                   
                 MSSPTRKVIMRTKTNAISWNPMEPMNFTAANEDCNCYSY 
               
               
                   
                   
                 DARKL EEAKCVHKDHVSAVMDIDYSPTGREFVTGSYDRT   
               
               
                   
                   
                   VRIFQ YNGGH SREVYHTKRMQRVFCVKFSCDASYVISGS   
               
               
                   
                   
                 
                   DDTNLRLWK 
                   AKASEQLGVVLPRERRKHEYHEAVKSRYKH 
                 
               
               
                   
                   
                 
                   LPEVKRIVRHRHLPKPIYKAGILRRTVNEADRRKEERRK 
                 
               
               
                   
                   
                   AHSAPGSSSAEPLRKRRIIKEI E 
               
               
                   
               
               
                 117 
                 The amino acid sequence of SEQ ID 
                 MVRSIKNPKKAKRKNKGSKNGDGSSSSSSIPSMPTKVWQ 
               
               
                   
                 383. The conserved G-protein beta 
                 PGVDKLEEGEELQCDPSAYNSLHAFHIGWPCLSFDIVRD 
               
               
                   
                 WD-40 repeat domains are 
                 TLGLVRTEFPHQVYFVAGTQAEKPTWNSIGIFKVSNITG 
               
               
                   
                 underlined. 
                 KRRELVPSKPTDDADEESDSSDSDEDSDDEVGGSGTPIL 
               
               
                   
                   
                 QLRKVGHEGCVNRIRAMNQNPHICASWGDSGHVQIWDFS 
               
               
                   
                   
                 SHLNALAESEADVSQGASSVFNQAPLVKFGGHKDEGYAL 
               
               
                   
                   
                 DWSPLVPGRLVSGDCKNSIHLWEPTSGSTW NVDSTPFIG   
               
               
                   
                   
                   HAASVEDLQWSPTEENVFASCSVDGTIAIWD TRLG KTPA   
               
               
                   
                   
                   ASFKAHDADVNVISWNRLATCMLASGCDDGTFSIHD LRL 
               
               
                   
                   
                 LKEG DSVVAHFEYHKHPVTSIEWSPHEASTLAVSSADCQ   
               
               
                   
                   
                   LTIWD LSLEKDEEEEAEFKAKTKEQVNAPEDLPPQLLFV 
               
               
                   
                   
                 HQGQKDLKELHWHAQIPGMIVSTAADGFNILMPSNIQST 
               
               
                   
                   
                 LPSDGA 
               
               
                   
               
               
                 118 
                 The amino acid sequence of SEQ ID 
                 MER YKVIKE LGDGTYGSVWKALNQQTHEIVAIKK MKRKY   
               
               
                   
                 384. The conserved eukaryotic 
                 
                   YIWEECINLREVKSLRKLNHPNIIKLKEVIRENNELFFI 
                 
               
               
                   
                 protein kinase domain is 
                 
                   FEYMECNLYQIMKERSTPFSETAIIKFCYQILQGLSYMH 
                 
               
               
                   
                 underlined and the protein kinases 
                 
                   RNGY FHRDLKPENLLV TSDLIKIADFGLAREVLTSPPYT 
                 
               
               
                   
                 ATP-binding region and 
                 
                   DYVSTRWYRAPEVLLQSPTYTTAIDMWAVGAILAELFTL 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   HPLFPGESELDEIYKICGVLGTPDYETWPDGMQLAAFRN 
                 
               
               
                   
                 active-site signatures are in 
                 
                   FIFPQFLPVNLSVLIPHASPEAIDLITRLCSWDPQKRPT 
                 
               
               
                   
                 bold. 
                   AEQALHHPFF RIGMSIPLSLGGHFQDNTCAAEVDTKFHS 
               
               
                   
                   
                 KKACKAWNGEKESSLECFLGLSLGLKPSLGHLGAMGSQG 
               
               
                   
                   
                 VGAVKQEVGSSPGCQSNPKQSLFQVLNSRAILPLFSSSP 
               
               
                   
                   
                 NLNVVPVKSSLPSAYTVNSQVMWPTIAGPPAAAVTVSTL 
               
               
                   
                   
                 QPSILGDFKIFGKSMGLASQYAGKEASPFS 
               
               
                   
               
               
                 119 
                 The amino acid sequence of SEQ ID 
                 MGEMGRGINNSSNNNNSNRPAWLQH YDLVGK IGEGTYGL     
               
               
                   
                 385. The conserved eukaryotic 
                 
                     VFLARSKLPNNRGLRIAIKK FKQSKDGDGVSPTAIREIM 
                 
               
               
                   
                 protein kinase domain is 
                 
                   LLREFSHENVVKLVNVHINHVDMSLYLAFDYAEHDLYEI 
                 
               
               
                   
                 underlined and the protein kinases 
                 
                   IRHHREKLNHHNINQYTVKSLLWQLLNGLNYLHSNW IVH   
                 
               
               
                   
                 ATP-binding region and 
                 
                     RDLKPSNI LVMGEGEEHGVVKIADFGLARIYQAPLKPLS 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   DNGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELI 
                 
               
               
                   
                 active-site signatures are boxed 
                 
                   TLKPLFQGVEVKASPNPFQLDQLDKIFKVLGHPTIEKWP 
                 
               
               
                   
                 in bold. 
                 
                   TLMNLPHWSKNLQQIQQHKYDNAGLHIGPIPAKSPAYDL 
                 
               
               
                   
                   
                   LSKMLEYDPRKRITAAQALEHEYF RIDPQPGRNALVPSQ 
               
               
                   
                   
                 PGEKAINYPPRLVDANTDFDGTIAPQPSQVSSGNAPSGS 
               
               
                   
                   
                 IASAAVPAVRPLPQQMQLMGMQRMQNPGMAAFNLGAQAS 
               
               
                   
                   
                 MSGLNHNNIALQRGSSQQQAHQQVRRKEPNSGFPNTGYP 
               
               
                   
                   
                 PPPKSRRL 
               
               
                   
               
               
                 120 
                 The amino acid sequence of SEQ ID 
                 MDK YEKLEK VGEGTYGKVYKARDKMTGQLVALK KTRLEM   
               
               
                   
                 386. The conserved protein kinase 
                 
                   DEEGVPPSSLREISLLQMLSQSIYVVRLLCVEHVTKKGK 
                 
               
               
                   
                 family domain is underlined. The 
                 
                   PLLYLVFEYLDTDLKKFIDYRRSVNAGPLPQNVIQSFMY 
                 
               
               
                   
                 protein kinases ATP-binding region 
                 
                   QLLKGVAHCHSHG VLHRDLKPQNLLV DKSKGLLKVGDLG 
                 
               
               
                   
                 is in bold and the 
                 
                   LGRAFTVPLKCYTHEVVTLWYRAPEVLLGSTHYSTPVDI 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   WSVGCIFAEMVRRQPLFPGDCEIQQLLHIFTLLGTPTEE 
                 
               
               
                   
                 active-site signature is in 
                 
                   MWPGVKRLRDWHEYPQWKPENLARAVPNLSPTGLDLISK 
                 
               
               
                   
                 bold/italics. 
                   MLQCDPAKRISAKAAMNHPYF DDLDKSQF 
               
               
                   
               
               
                 121 
                 The amino acid sequence of SEQ ID 
                 MDG YEKMDK VGEGTYGKVYMARDKKTGQLVALK KTRLEN   
               
               
                   
                 387. The conserved protein kinase 
                 
                   DGEGIPPTALREISLLQMLSQDIYIVRLLDVKHTENKLG 
                 
               
               
                   
                 family domain is underlined. The 
                 
                   KPLLYLVFEYMESDLKKYIDSYRRSHTKMPPSMIKSFMY 
                 
               
               
                   
                 protein kinases ATP-binding region 
                 
                   QLCRGVAYCHSRG DKEKGVLKIADLG 
                 
               
               
                   
                 is in bold and the 
                 
                   LSRAFTVPVKKYTHEIVTLWYRAPEVLLGATHYSLPVDI 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   WSVGCIFAEMSRMQALFTGDSEVQQLMNIFRFLGTPNEE 
                 
               
               
                   
                 active-site signature is in 
                 
                   VWPGVTKLKDWHIYPEWKPQDISHAVPDLEPSGLDLLSQ 
                 
               
               
                   
                 bold/italics. 
                   MLVYEPSKRISAKKALEHPYF DDLDKSQF 
               
               
                   
               
               
                 122 
                 The amino acid sequence of SEQ ID 
                 MDAYEK LEK VGEGTYGKVYKAKDKNTGQLVALK KTRLES   
               
               
                   
                 388. The conserved eukaryotic 
                 
                   DDEGIPPTALREISLLQMLSQDIHIVRLLDVEHTENKNG 
                 
               
               
                   
                 protein kinase domain is 
                 
                   KPLLYLVFEYMDSDLKKYIDGYRRSHTKVPPNIIKSFMY 
                 
               
               
                   
                 underlined and the protein kinases 
                 
                   QLCQGVAYCHSRG VMHRDLKPHNLLV DKQRGVVKIADLG 
                 
               
               
                   
                 ATP-binding region and 
                 
                   LGRAFTIPIKKYTHEIVTLWYRAPEVLLGATHYSTPVDI 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   WSVGCIFAEMVRLQALFIGDSEVQQLFKIFSFLGTPNEE 
                 
               
               
                   
                 active-site signatures are in 
                 
                   IWPGVTKFRDWHIYPQWKPQDISSAVPDLEPSGVDLLSK 
                 
               
               
                   
                 bold. 
                   MLVYEPSKRISAKKALEHPYF DDLDKSQF 
               
               
                   
               
               
                 123 
                 The amino acid sequence of SEQ ID 
                 MDS YEKLEK VGEGTYGKVYKAKDKKTGKLVALK KTRLEN   
               
               
                   
                 389. The conserved protein kinase 
                 
                   DGEGIPPTALREISLLQMLSQDMNIVRLLDVEHTENKNG 
                 
               
               
                   
                 family domain is underlined. The 
                 
                   KPLLYLVFEYMDSDLKKYVDGYRRSHTKMPPKIIKSFMY 
                 
               
               
                   
                 protein kinases ATP-binding region 
                 
                   QLCQGVAYCHSRG DKQRGVLKIADLG 
                 
               
               
                   
                 is in bold and the 
                 
                   LGRAFTVPIKKYTHEIVTLWYRAPEVLLGATHYSTPVDI 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   WSVGCIFAEMSRMHALFCGDSEVQQLMSIFKFLGTPNEG 
                 
               
               
                   
                 active-site signature is in 
                 
                   VWPGVTKLKDWHIYPEWRPQDLSRAVPDLEPSGVDLLTK 
                 
               
               
                   
                 bold/italics. 
                   MLVYEPSKRISAKKALQHPYF DDLDKSQF 
               
               
                   
               
               
                 124 
                 The amino acid sequence of SEQ ID 
                 MEK YEKLEK VGEGTYGKVYKGRDKRTGRLVALK KTPFHQ   
               
               
                   
                 390. The conserved eukaryotic 
                 
                   EEGIPPTAIREISLLKSLSQCIYIVKLLDVKASFNGKGK 
                 
               
               
                   
                 protein kinase domain is 
                 
                   HVLFMVFEYADSDLKKHIDAHRQCNTKLSPRSIQSYMFQ 
                 
               
               
                   
                 underlined and the protein kinases 
                 
                   LCKGIAYCHSHG VLHRDLKPQNILV DQKIGLLKIADLGL 
                 
               
               
                   
                 ATP-binding region and 
                 
                   GRACTVPIKSYTFEVVTLWYRAPEVLLGAKRYSMALDIW 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   SLGCIFAELCNLQALFAGDSQIQQLINIFRLLGTPNEQL 
                 
               
               
                   
                 active-site signatures are in 
                 
                   WPGVTQLSDWHEFPQWRPQDLSKVVFNLDPNGVDLLSKM 
                 
               
               
                   
                 bold. 
                   LQYDPAKRISAKEALDHPYF DSLDKSQF 
               
               
                   
               
               
                 125 
                 The amino acid sequence of SEQ ID 
                 MGCVCGKPSARAADYVESPAEKGASSNSRSSSMASRRLV 
               
               
                   
                 391. The conserved eukaryotic 
                 APAVMDQGIDAENGHEGDYRTKLRGKQSNGADPVSLLSD 
               
               
                   
                 protein kinase domain is 
                 DAEKQRHSRHHQHQQHHPIRPHHLRPQGEFVPNANSNPR 
               
               
                   
                 underlined and the 
                 FGNPPRHIEGEQVAAGWPAWLTAVAGEAIKGWIPRRADS 
               
               
                   
                 serine/threonine protein kinases 
                 
                   FEKLDKIGQGTYSNVYKARDLDTGKIVALKKVRFDNLEP 
                 
               
               
                   
                 active-site signatures are in 
                 
                   ESVRFMAREIQVLRRLDHPNVVKLEGLVTSRMSCSLYLV 
                 
               
               
                   
                 bold. 
                 
                   FEYMDHDLAGLAACPGIKFTEPQVKCYMQQLLRGLDHCH 
                 
               
               
                   
                   
                 
                   SRGV LHRDIKGSNLLI DNGGILKIADFGLATFFHPDQRQ 
                 
               
               
                   
                   
                 
                   PLTSRVVTLWYRPPELLLGATEYGVAVDLWSTGCILAEL 
                 
               
               
                   
                   
                 
                   LAGKPIMPGRTEVEQLHKIFKLCGSPSEDYWKKSKLPHA 
                 
               
               
                   
                   
                 
                   TIFKPQQPYKRCVAETFKDFPPSALALMEVLLAIEPADR 
                 
               
               
                   
                   
                   GTATSALKSDFF TTKPLACDPSSLPKYPPSKEFDAKIRD 
               
               
                   
                   
                 EEARRQRAAGGRGRDAARRPSRESRAIPAPEANAELAIS 
               
               
                   
                   
                 IQKRRLSSQGPSKSKSEKFNPQQEDGAVGFPIEPPRPMH 
               
               
                   
                   
                 IGIDAGATSRMYSQQFGPSHSGPLSNQISSSIWGKNQKE 
               
               
                   
                   
                 DEIQMAPGRPSRSSKATISDFRKPGACAPQPGADLSHLS 
               
               
                   
                   
                 SLVATARSNAGIDTHKDRSGMWQHNRIDAIDGVHNNGKH 
               
               
                   
                   
                 EFLEVPEHPNRQDWTRFQQPESFKGLDNYHLQDLPATHH 
               
               
                   
                   
                 RKDERVASKEATMNWQGYGGQGGDKIHYSGPLLPPSGNI 
               
               
                   
                   
                 DEILKEHERHIQHAVRRARQDKGRPQRSNLSQNERKAFE 
               
               
                   
                   
                 HRSFVSGVNGNAGYSDLVNELPISVGSNRLKVSKTRGTE 
               
               
                   
                   
                 EIVELRELEREPLSSVMEKYEREHEM 
               
               
                   
               
               
                 126 
                 The amino acid sequence of SEQ ID 
                 MGCVCAKQSDILGEPESPKVKGSNLASSRWSVSSETKQL 
               
               
                   
                 392. The conserved eukaryotic 
                 PQHSDSGILHHQHYYHPRDESDEAKLKESNYGGSKRRTR 
               
               
                   
                 protein kinase domain is 
                 QGRDPADLDMGIFVRTPSSQSEAELVAAGWPAWMAAFAG 
               
               
                   
                 underlined and serine/threonine 
                 EAIHGWIPRRAES FEKLYKIGQGTYSNVYKARDLDNGKI   
               
               
                   
                 protein kinases active-site 
                 
                   VALKKVRFDSLDAESVRFMAREILVLRKLDHPNIVKLEG 
                 
               
               
                   
                 signatures is in bold. 
                 
                   LVTSEVSSSLYLVFEYMEHDLAGLAACPGIKFTEPQVKC 
                 
               
               
                   
                   
                 
                   YMQQLLQGLDHCHRHG VLHRDIKGSNLLI DNGGILKIAD 
                 
               
               
                   
                   
                 
                   FGLATFFYPDQKQLLTSRVVTLWYRPPELLLGATDYGVA 
                 
               
               
                   
                   
                 
                   VDIWSAGCILAELLAGKPILPGRTEVEQLHKIFKLCGSP 
                 
               
               
                   
                   
                 
                   SEDYWKESKLPHATIFKPQHPYKSCIAEAFKDFSPSALA 
                 
               
               
                   
                   
                   LLETLLAIEPGHRGEASGALKSEFF TTEPLSCDPSSLPK 
               
               
                   
                   
                 YPPSKEFDAKLRAQETRRQRDVGVRGHGSEAARRTSRLS 
               
               
                   
                   
                 RAGPTPNEGAELTALTQKQHSTSHATSNIGSEKPSTKKE 
               
               
                   
                   
                 DYTAGLHIDPPRPVNHSYETTGVSRAYDAIRGVAYSGPL 
               
               
                   
                   
                 SQTHVSGSTSGKKPKRDHVKGLSGQSSLQPSKPFIVSDS 
               
               
                   
                   
                 RSERIYEKSHVTDLSNHSRLAVGRNRDTTDPHKSLSTLM 
               
               
                   
                   
                 QQIQDGTLDGIDIGTHEYARAPVSSTKQKSAQLQRPSAL 
               
               
                   
                   
                 KYVDNVQLQNTRVGSRQSDERPANKESDMVSHRQGQRIH 
               
               
                   
                   
                 CSGPLLHPSANIEDLLQKHEQQIQQAVRRAHHGKREALS 
               
               
                   
                   
                 NKSSLPGKKPVDHRAWVSSGKGNKESPYFKGKGNKELSD 
               
               
                   
                   
                 LKGGPTAKVTNFRQKVM 
               
               
                   
               
               
                 127 
                 The amino acid sequence of SEQ ID 
                 MAVANPGQLNLQEAPSWGSRSVNC FEKLEQ IGEGTYGQV     
               
               
                   
                 393. The conserved protein kinase 
                 
                     YMAKEIETGEIVALK KIRMDNEREGFPITAIREIKLLKK 
                 
               
               
                   
                 family domain is underlined. The 
                 
                   LQHENVIKLKEIVTSPGPEKDEQGKSDGNKYNGSIYMVF 
                 
               
               
                   
                 protein kinases ATP-binding region 
                 
                   EYMDHDLTGLAERPGMRFSVPQIKCYMKQLLIGLHYCHI 
                 
               
               
                   
                 is in bold and the 
                 
                   NQ 
                   
                   DNNGILKLADFGLARSFCSDQNGN 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   LTNRVITLWYRPPELLLGSTKYGPAVDMWSVGCIFAELL 
                 
               
               
                   
                 active-site signature is in 
                 
                   YGKPILPGKNEPEQLTKIFELCGSPDESNWPGVSKLPWY 
                 
               
               
                   
                 bold/italics. 
                 
                   SNFKPQRQMKRRVRESFKNFDRHALDLVEKMLTLDPSQR 
                 
               
               
                   
                   
                   ISAKDALDAEYF WTDPVPCAPSSLPRYEPSHDFQTKRKR 
               
               
                   
                   
                 QQQRQHDEMTKRQKISQHPPQQHVRLPPIQNAGQGHLPL 
               
               
                   
                   
                 RPGPNPTMHNPPPQFPVGPSHYTGGPRGAGGQNRHPQNI 
               
               
                   
                   
                 RPLHAAQGGGYNANRGYGGPPQQQGGGYPPHGMGNQGPR 
               
               
                   
                   
                 GGQFGGRGAGYSQGGPYGGPVGGRGPNVGGGNRGPQFWS 
               
               
                   
                   
                 EQ 
               
               
                   
               
               
                 128 
                 The amino acid sequence of SEQ ID 
                 MQNMEDNVQSSWSLHGNKEICAR YEILERVGSGTYSDVY   
               
               
                   
                 394. The conserved eukaryotic 
                 
                   RGRRKADGLIVALKEVHDYQSSWREIEALQRLCGCPNVV 
                 
               
               
                   
                 protein kinase domain is 
                 
                   RLYEWFWRENEDAVLVLEFLPSDLYSVIKSGKNKGENGI 
                 
               
               
                   
                 underlined and the 
                 
                   PEAEVKAWMIQILQGLADCHANW VIHRDLKPSNLLI SAD 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   GILKLADFGQARILEEPEAIYEVEYELPQEDIVADAPGE 
                 
               
               
                   
                 active-site signature is in bold. 
                 
                   RLMEEDDSVKGVRNEGEEDSSTAVETNFGDMAETANLDL 
                 
               
               
                   
                   
                 
                   SWKNEGDMVMQGFTSGVGTRWYRAPELLYGATIYGKEID 
                 
               
               
                   
                   
                 
                   LWSLGCILGELLILEPLFSGTSDIDQLSRLVKVLGTPTE 
                 
               
               
                   
                   
                 
                   ENWPGCSNLPDYRKLCFPGDGSPVGLKNHVPSCSDSVFS 
                 
               
               
                   
                   
                   ILERLVCYDPAARLNAKEVLENKYF VEDPYPVLTHELRV 
               
               
                   
                   
                 PSPLREENNFSEDWAKWKDMEADSDLENIDEFNVVHSSD 
               
               
                   
                   
                 GFCIKFS 
               
               
                   
               
               
                 129 
                 The amino acid sequence of SEQ ID 
                 MDLNQYPEDLNPELPEGTDNVDNPDNNKGSPVPSPHPPL 
               
               
                   
                 395. The conserved eukaryotic 
                 KPLDPSER YRKGIT LGQGTYGIVYKAFDTVTNKTVAVKK     
               
               
                   
                 protein kinase domain is 
                 
                   IHLGKAKEGVNVTALREIKLLKELSHPNIIQLIDAYPHK 
                 
               
               
                   
                 underlined and the protein kinases 
                 
                   QNLHIVFEFMETDLEAVIKDRNLVFSPADIKSYLQMTLK 
                 
               
               
                   
                 ATP-binding region and 
                 
                   GLAVCHKKW VLHRDMKPNNLLI AADGQLKLGDFGLARLF 
                 
               
               
                   
                 serine/threonine protein kinases 
                 
                   GSPDRKFTHQVFAVWYRAPELLFGAKQYGPAVDIWATGC 
                 
               
               
                   
                 active-site signatures are in 
                 
                   IFAELLLRKPFLQGVSDLDQIGKIFAAFGTPRQSQWPDV 
                 
               
               
                   
                 bold. 
                 
                   ASLPDFVEFQFVPAPSLRSLFPMASEDALDLLSKMFTLD 
                 
               
               
                   
                   
                   PKNRITAQQALEHRYF SSVPAPTRPDLLPKPSKVDSSRP 
               
               
                   
                   
                 PKHASPDGPVVLSPSKARRVMLFPNNLAGILPKQVSQST 
               
               
                   
                   
                 TGGTPIEFDMPTQKLREVCPRSRITESGKKHLKRKTMDM 
               
               
                   
                   
                 SAALDECAREQEGQEGKTILDPDHQRSAKKEKHM 
               
               
                   
               
               
                 130 
                 The amino acid sequence of SEQ ID 
                 MAGGQENCVRITRARAACVSKASAPVIQSQVDEKKSRKR 
               
               
                   
                 396. The conserved cyclin N- and 
                 APKRAAVDDLAANASGSQPKRRAVLGDVTNLHAAATDCL 
               
               
                   
                 C-terminal family domains are 
                 STAEDQVDAPNPSIKGRARNKKKEARTSTKVVKDEIHPE 
               
               
                   
                 underlined. 
                 SNPLADHSSNLSECQKPPAAKLAEQRSLRGVPSKAKQGG 
               
               
                   
                   
                 SSNSQSCSKHTDIDKDHTDPQMCTTYVE DIYEYLRNAEL   
               
               
                   
                   
                 
                   KNRPSANFMETAQNDITPNMRAILVDWLVEVSEEYKLVP 
                 
               
               
                   
                   
                 
                   DTLYLTVSYIDRYLSANPTSRHKLQLLGVSCMLIASKYE 
                 
               
               
                   
                   
                 
                   EVCPPHVEEFCYITDNTYTRDEMLSMERKILIFLNFEMT 
                 
               
               
                   
                   
                 K PTTKSFLRRFVRASQAGNKAPSLHMEFLANYLAELTLM   
               
               
                   
                   
                 
                   ECSFLQYLPSLIAASTVFLSRLTLDFLTNPWNPTLAHYT 
                 
               
               
                   
                   
                 
                   GYKASQLKDCVMAIYNVQMNRKGSTLVAIREKYQQHKFK 
                 
               
               
                   
                   
                   CVASLPPPPFIA ERFFDTPN 
               
               
                   
               
               
                 131 
                 The amino acid sequence of SEQ ID 
                 MTGTQASNVRITRARAAKSTLNNALPPLPPAQGKPRGKR 
               
               
                   
                 397. The conserved cyclin and 
                 AATESNISGFSVAAEPLKRRAVLSDVSNICKEAAAVDCL 
               
               
                   
                 cyclin C-terminal domains are 
                 KKPKAVKVVSQNANAKGRGRGIPRNNKKITQEAEIKKET 
               
               
                   
                 underlined and the cyclins 
                 SPAICNVDDASAGNAIGDDKQNNNVNPLKEVQDNPKELN 
               
               
                   
                 signature is in bold. 
                 PIAEQISVHPHCKQSVEKPNEKEIVVSDNKAAIASLKQQ 
               
               
                   
                   
                 STLQSLRIPKQPKYSLKQGNPVPLANLHEDVGRSSCSDF 
               
               
                   
                   
                 IDIDSEYKDPQMCTAYVT DIYANMRVVELKRRPLPNFME   
               
               
                   
                   
                 
                   TTQRDINANM RSVLIDWLVEVSEEYKLVPDTLYLTVSYI   
                 
               
               
                   
                   
                 
                     DRF LSANVVNRQRLQLLGVSCMLVASKYEEICAPPVEEF 
                 
               
               
                   
                   
                 
                   CYITDNTYKKEEVLEMEISVLNRLQYDLTTPTTKTFLRR 
                 
               
               
                   
                   
                 
                   FIRAAQASCKVSSLHLEFMGNYLAELTLVEYDFLKYLPS 
                 
               
               
                   
                   
                 
                   LIAAAAVFVARMTLDPMVHPWNSTLQHYTGYKVSDMRDC 
                 
               
               
                   
                   
                 
                   ICAIHDLQLNRKGCTLAAIREKYNQPKFKCVANLFPPPI 
                 
               
               
                   
                   
                   IS PQFLIDNEV 
               
               
                   
               
               
                 132 
                 The amino acid sequence of SEQ ID 
                 MAAPNQNALLINNNNRRPLVDIGNLVGALNAQCNISKNG 
               
               
                   
                 398. The conserved cyclin and 
                 ARKRAFGDIGNLVEDLDAKCTISKYWVRKRPRTNFGVNA 
               
               
                   
                 cyclin C-terminal domains are 
                 NKGASSSTQGQGIVVRGEQKAWDRIVWGNKQSCAIKMNA 
               
               
                   
                 underlined and the cyclins 
                 QHVTATQRGTAISISDIIDSSVQDGGIKAPSQLKARKQT 
               
               
                   
                 signature is in bold. 
                 VRTVTATLTARSEDSLRDVLEVPPGIDDGDRDNPLAVVE 
               
               
                   
                   
                 YVE DIYHFYRKIEVRSCVPPDYMTRQLEIKDSM RGVIID     
               
               
                   
                   
                 
                     WLIEVHRTFLLMPETLYLTVNIIDRY LSIQSVTRNELQL 
                 
               
               
                   
                   
                 
                   MGITAMFIASKYEEISPPKINDLVYITKDAYTSKQIVNM 
                 
               
               
                   
                   
                   EHTILNRLKFKLT V PTPYVFLVRFLKAAGPDKVMKNLAF   
               
               
                   
                   
                 
                   FLVDLCLLHYKMIKYSPSMLAAAAVYTAQCTLKKHPYWN 
                 
               
               
                   
                   
                 
                   KTLILHIGYSEAHLRECAHLMADLHLKAEGSNLKSVYKK 
                 
               
               
                   
                   
                   YSYPIFGSVAFLSPAKIPA GTVAAPAIDKCAHQIYLRNLR 
               
               
                   
               
               
                 133 
                 The amino acid sequence of SEQ ID 
                 MFPNKQTQGLVQNKKMASKAAQPKAMVPPQRVPPAANNR 
               
               
                   
                 399. The conserved cyclin N- and 
                 RALGDIGNIVADVGGKCNVTKDGVNGKPLAQVSRPITRS 
               
               
                   
                 C-terminal family domains are 
                 FGAQLLAQAAANKGISAANNQTQVPVVIPKADVRGNKQR 
               
               
                   
                 underlined. 
                 RTSKSKDIPPTTVVTNESDDCVIIEQAQRIKPTCNHNVG 
               
               
                   
                   
                 AVGNKEKPQLLTAKPKSLTASLTSRSAVALRGFRFDDEM 
               
               
                   
                   
                 TEAEEDPLPNIDVGDRDNQLAVVEYVE DIYKFYRRTEQM   
               
               
                   
                   
                 
                   SCVPDYMPRQQEINPKMRAVLINWLIEVHYRFGLMPETL 
                 
               
               
                   
                   
                 
                   YLTTNLIDRYLATQLVSRSNYQLVGATAMLLASKYEEIW 
                 
               
               
                   
                   
                   APEMNDFLDILENKFERKHVLVMEKAMLNKLKFHLT V PT   
               
               
                   
                   
                 
                   PYVFLVRFLKAAASDEEMENLVFFLMELSLMQYVMIKFP 
                 
               
               
                   
                   
                 
                   PSMLAAAAVYTAQITLKKTTVWNDVLKRHTGYSEIDLKE 
                 
               
               
                   
                   
                 
                   CTRLMVAFHQSSEESKLNVVFKKYSMPEYDSVALIKPAK 
                 
               
               
                   
                   
                   LP A 
               
               
                   
               
               
                 134 
                 The amino acid sequence of SEQ ID 
                 MAPSFDCVANAYIESCEDQEKLRQNAQILAQSGENDVD E   
               
               
                   
                 400. The conserved cyclin and 
                 
                   PVSMLVQRETHYMLPEDYLQRLRNRTLDVNVRREAVGWI 
                 
               
               
                   
                 cyclin C-terminal domains are 
                 
                   LKVHSFYNFSAPTAYLAVNYLDRFLSRHRMPQGVKAWMI 
                 
               
               
                   
                 underlined 
                 
                   QLMAVACLSLAAKMEETQVPLPSDLQREDARFIFDARTI 
                 
               
               
                   
                   
                   QRMELLILSTLQWGMR S ITPFSFIDYFAYRAVQGHGHGH   
               
               
                   
                   
                 
                   DATPKAVMSRAIELILSTTEEIDFMEYRPSAIAAAALLC 
                 
               
               
                   
                   
                 
                   AAEEVVPLQAVHYKRALSSSITDVDKDKMFGCYNLIQET 
                 
               
               
                   
                   
                   IIEGGCYWTPMSLQSTEKTPVGVLDAAACLSNTPTSS YS 
               
               
                   
                   
                 VKPYASVTAAKRRKLNEICSALLVSQAHPC 
               
               
                   
               
               
                 135 
                 The amino acid sequence of SEQ ID 
                 MAANFWTSSHCKELLDAEKVGIVHPLDKDQGLTQEDVKI 
               
               
                   
                 401. The conserved cyclin and 
                 IKINMS NCIRTLAQYVKLRQRVVATAITYCRRVYTRKSF   
               
               
                   
                 cyclin C-terminal domains are 
                 
                   TEYDPQLVAPTCLYLASKAEESTVQAKLVIFYMKKYSKH 
                 
               
               
                   
                 underlined. 
                   RYEIKDMLEMEMKLLE ALDYYLVIYHPY RPLIQFLQDAG   
               
               
                   
                   
                 
                   LNDLKVTAWALVNDTYRTDLILTYPPYMIALACIYFACI 
                 
               
               
                   
                   
                   MEEKDAQAWFEELRVDMNEIKNISMEIVD YYDNYRVIPD 
               
               
                   
                   
                 EKMNSALNKLPHRF 
               
               
                   
               
               
                 136 
                 The amino acid sequence of SEQ ID 
                 MAPALSSSYECLSHLLCAEDASNVVGCWDEDESKIFCEE 
               
               
                   
                 402. The conserved cyclin domain 
                 EEGFGIQHFPDFPVPDD DEIRVLVRKESQYMPGKSYVQS   
               
               
                   
                 is underlined. 
                 
                   YQNLGLDFTARQNAIGWILKVHGSYNFGPLTAYLSINYL 
                 
               
               
                   
                   
                 
                   DRFLSRNPLPKAKVWMLQLLSVACLSLAAKMEETQVPLL 
                 
               
               
                   
                   
                   LDLQAEEPDFLFEPRTIQRMELLVLSTLEWRML SVTPFS 
               
               
                   
                   
                 FVDYFLQGGGGRKPPPRAMVARANELIFNTHTVLDFLEH 
               
               
                   
                   
                 RPSAIAAAAVICAAEEVLPLEAAQYKETILSCSLVDKEW 
               
               
                   
                   
                 VFGSYNLIQEVLIEKFSTPKKAKSASSSIPQSPVGVLDA 
               
               
                   
                   
                 FCLSNNSNNTSLEASLSVNLYASVAAKRRKLNDYCNTWR 
               
               
                   
                   
                 MFQHSTC 
               
               
                   
               
               
                 137 
                 The amino acid sequence of SEQ ID 
                 MAPNCIDCAPSDLFCAEDAFGVVEWGDAETGSLYGDEDQ 
               
               
                   
                 403. The conserved cyclin domain 
                 LHYNLDICDQHDEHLWDDG ELVAFAEKETLYVPNPVEKN   
               
               
                   
                 is underlined. 
                 
                   SAEAKARQDAVDWILKVHAHYGFGPVTAVLSINYLDRFL 
                 
               
               
                   
                   
                 
                   SANQLQQDKPWMTQLAAVACLSLAAKMDETEVPLLLDFQ 
                 
               
               
                   
                   
                   VEEAKYIFESRTIQRMELLVLSTLEWRMS PVTPLSYIDH 
               
               
                   
                   
                 ASRMIGLENHHCWIFTMRCKEILLNTLRDAKFLGLLPSV 
               
               
                   
                   
                 VAAAIMLHVIKETELVNPCEYENRLLSAMKVNKDMCERC 
               
               
                   
                   
                 IGLLIAPESSSLGSFSLGLKRKSSTINIPVPGSPDGVLD 
               
               
                   
                   
                 ATFSCSSSSCGSGQSTPGSYDSNNSSILCISPAVIKKRK 
               
               
                   
                   
                 LNYEFCSDLHCLED 
               
               
                   
               
               
                 138 
                 The amino acid sequence of SEQ ID 
                 
                   MPQIQ YSEKYTDDTYEYRHVVLPP ETAKLLPKNRLLNEN 
                 
               
               
                   
                 404. The conserved cyclin- 
                   EWRAIGVQQSRGWVHYAIHRPEPHIMLFRRPLN YQQNQQ 
               
               
                   
                 dependent kinases regulatory 
                 QQAGAQSQPMGLKAQ 
               
               
                   
                 subunit domain is underlined and 
               
               
                   
                 the cyclin-dependent kinases 
               
               
                   
                 regulatory subunits signature 1 is 
               
               
                   
                 in bold. 
               
               
                   
               
               
                 139 
                 The amino acid sequence of SEQ ID 
                 
                   MDQIE YSEKYYDDTYEYRHVELPP DVARLLPKNRLLTEN 
                 
               
               
                   
                 405. The conserved cyclin- 
                   EWRGIGVQQSRGWVHYAIHCSEPHIMLFRRPLN YEQNHQ 
               
               
                   
                 dependent kinases regulatory 
                 HPEPHIMLFRRPLNCQPNHQPQAHHPT 
               
               
                   
                 subunit domain is underlined and 
               
               
                   
                 the cyclin-dependent kinases 
               
               
                   
                 regulatory subunits signature 1 is 
               
               
                   
                 in bold. 
               
               
                   
               
               
                 140 
                 The amino acid sequence of SEQ ID 
                 
                   MDQIE YSEKYYDDTYEYRHVELPP DVARLLPKNRLLTEN 
                 
               
               
                   
                 406. The conserved cyclin- 
                   EWRGIGVQQSRGWVHYAIHCSEPHIMLFRRPLN YEQNHQ 
               
               
                   
                 dependent kinases regulatory 
                 HPEPHIMLFRRPLNCQPNHQPQAHHPT 
               
               
                   
                 subunit domain is underlined and 
               
               
                   
                 the cyclin-dependent kinases 
               
               
                   
                 regulatory subunits signature 1 is 
               
               
                   
                 in bold. 
               
               
                   
               
               
                 141 
                 The amino acid sequence of SEQ ID 
                 
                   MPQIQ YSEKYYDDTYEYRHVVLPP DVARLLPKNRLLNEN 
                 
               
               
                   
                 407. The conserved cyclin- 
                   EWRGIGVQQSRGWVHYAIHRPEPHIMLFRRHLN YQQNQQ 
               
               
                   
                 dependent kinases regulatory 
                 QQAQQQPAQAMGLQA 
               
               
                   
                 subunit domain is underlined and 
               
               
                   
                 the cyclin-dependent kinases 
               
               
                   
                 regulatory subunits signature 1 is 
               
               
                   
                 in bold. 
               
               
                   
               
               
                 142 
                 The amino acid sequence of SEQ ID 
                 MALVETEPVTLIHPEEPKKFKKKPTPGRGGVISHGLTEE 
               
               
                   
                 408. The conserved GCN5-related N- 
                 EARVKAIAEIVGAMVEGCRKGEDVDLNALKAAACRRYGL 
               
               
                   
                 acetyltransferase family domain is 
                 SRAPKLVEMIAALPDGERAAVLPKLKAKPVRTASGIAVV 
               
               
                   
                 underlined and the radical SAM 
                 AV MSKPHRCPHIATTGNICVYCPGGPDSDFEYSTQSYTG   
               
               
                   
                 family domain is in bold. 
                 
                   YEPTSMRAIRARYNPYVQTRSRIDQLKRLGHTVDKVEFI 
                 
               
               
                   
                   
                 
                   LMGGTFMSLPADYRDYFIRNLHDALSGHTSSNVEEAVCY 
                 
               
               
                   
                   
                 
                   SEHSATKCIGLTIETRPDYCLGPHLRQMLSYGCTRLEIG 
                 
               
               
                   
                   
                 
                   VQSTYEDVARDTNRGHTVAAVADCFCLAKDAGFKVVAHM 
                 
               
               
                   
                   
                   MPDLPNVGVERDMESFREFF ENPAFRADGLKIYPTLVIR 
               
               
                   
                   
                 GTGLYELWKTGRYRNYPPEQLVDIIARVLALVPPWTRVY 
               
               
                   
                   
                 RVQRDIPMPLVTSGVEKGNLRELALARMDDLGLKCRDVR 
               
               
                   
                   
                 TREAGIQDIHHKIRPEVVELVRRDYCANEGWETFLS YED   
               
               
                   
                   
                 
                   TRQDILVGLLRLRKCGHNTTCPELKGRCSIVRELHVYGT 
                 
               
               
                   
                   
                 
                   AVPVHGRDADKLQHQGYGTLLMEQAERIAWKEHRSIKIA 
                 
               
               
                   
                   
                   VISGVGTRHYYRKLGYE LEGPYMMKYLN 
               
               
                   
               
               
                 143 
                 The amino acid sequence of SEQ ID 
                 MLGFRDLYTSICEHLQRASGRLPIIAAATSLISTPEIAA 
               
               
                   
                 409. The conserved chromo domain 
                 VEKENKAPNSVDKMGMGSADESGRFSTSNGQFMNMNNGV 
               
               
                   
                 is underlined and the MOZ/SAS-like 
                 VKEEWKGGVPVVPSAPTTVPVITNVKLETPSSPDHDMAR 
               
               
                   
                 protein domain is in bold. 
                 KRKLGFLPLEVGTRVLCKWRDG KFHPVKIIERRKLPNGA   
               
               
                   
                   
                 
                   TNDYEYYVHYTEFNRRLDEWVKLEQLELDSVETDADEKV 
                 
               
               
                   
                   
                   DDKA GSLKMTRHQKRKIDETHVEGNEELDAASLREHEEF 
               
               
                   
                   
                 TKVKNITKIELGRYEIETWYFSPFPSEYNNCEKLYFCEF 
               
               
                   
                   
                 CLNFMKRKEQLQRHMRKCD LKHPPGDEIYRSGTLSMFEV   
               
               
                   
                   
                 
                   DGKKNKVYAQNLCYLAKLFLDHKTLYYDVDLFLFYILCE 
                 
               
               
                   
                   
                 
                   CDERGCHMVGYFSKEKHSEESYNLACILTLPPYQRKGYG 
                 
               
               
                   
                   
                 
                   KFLISFSYELSKKEGKVGTPERPLSDLGLLSYRGYWTRV 
                 
               
               
                   
                   
                 
                   LLDILKKHKSNISIKELSDMTAIKADDVLSTLQGLDLIQ 
                 
               
               
                   
                   
                   YRKGQHAICAD PKVLDRHLKAVGRGGLEVDVCKLIWTPY 
               
               
                   
                   
                 KEQ 
               
               
                   
               
               
                 144 
                 The amino acid sequence of SEQ ID 
                 MGSLDESTCSEEIRDEGKDSIRTKFKVESTVNNAQNGGN 
               
               
                   
                 410. The conserved MOZ/SAS-like 
                 DNSKKKRAAGLPLEVGIRLLCKWRDSKLHPVKIIERRKL 
               
               
                   
                 protein domain is underlined. 
                 PNGFPQDYEYYVHYTEFNRRLDEWVKLEQFELDSVETDA 
               
               
                   
                   
                 DEKIEDKGGSLKMTRHQKRKIDEIHVEEGQGHEDFDPAS 
               
               
                   
                   
                 LREHEEFTKVKNIAKVELGRYEIETWYFSPFPPEYSHCE 
               
               
                   
                   
                 KLFFCEFCLNFMKRKEQLQRHMRKCD LKHPPGDEIYRNG   
               
               
                   
                   
                 
                   TLSMFEVDGKKNKIYGQNLCYLAKLFLDHKTLYYDVDLF 
                 
               
               
                   
                   
                 
                   LFYVLCECDDRGCHVVGYFSKEKHSDEAYNLACILTLPP 
                 
               
               
                   
                   
                 
                   YQRKGYGKFLIAFSYELSKKEGKVGTPERPLSDLGLLSY 
                 
               
               
                   
                   
                 
                   RGYWTRILLDILKKQRGNISIKELSDMTAIKVEDVISTL 
                 
               
               
                   
                   
                   QVLDLIQYRKGQHVICAD PKVLDRHLKAAGIAGLEVDVS 
               
               
                   
                   
                 KLIWTPYKEQCG 
               
               
                   
               
               
                 145 
                 The amino acid sequence of SEQ ID 
                 MASAPMVGCDDSRDKHRWVESKVYMRKGHGKGSKGNAGF 
               
               
                   
                 411. The conserved bromo family 
                 NAQNSTAQVRRENDNMGNSIADNGKSEAASEGLSSLSRK 
               
               
                   
                 domain is underlined. 
                 QITVNQDHPPNETSSMPAVGGLQNIDTHVTFKLEGCSKQ 
               
               
                   
                   
                 EIWELRKKLTNELEQVRGTFKKLEARELQLRGYSVSAGV 
               
               
                   
                   
                 NTSYSASQFSGNDMRNNGGKEVTSEVASGGAITPKQAQR 
               
               
                   
                   
                 ESNPPRQLSISLMENNQAASDMGEKGKRTPKANQYYRNS 
               
               
                   
                   
                 EFVLGKDKFPPAESKKSKSTGNKKISQSKVFSKETMQVG 
               
               
                   
                   
                 KEFMPQKSVN EVFKQCSLLLTKLMKHKYGWVFNLPVDAQ   
               
               
                   
                   
                 
                   ALGLHDYHTIIKRPMDLGTVKSKLEKNLYNSPASFAEDV 
                 
               
               
                   
                   
                   KLTFSNAMTYNPKGHEVHTMAEQ LLQLFEERWKTIYEEH 
               
               
                   
                   
                 LDGKMRFGSGQGLGASSSTKKLPFQDSKKNIKKSEPAGG 
               
               
                   
                   
                 PSPPKPKSTNHHASRTPSAKKPKAKDPHKRDMTYEEKQK 
               
               
                   
                   
                 LSTNLQNLPQERLELIVQIIKKRNPSLCQHDEEIEVDID 
               
               
                   
                   
                 SFDTETLWELDRFVTNYKKSLSKNKKKALLADQAKRASE 
               
               
                   
                   
                 HGSARNKHPMIGRELPMNNKKGEQGEKVVEIDHMPPVNP 
               
               
                   
                   
                 PVVEVEKDGVYAKRSSSSSSSSSDSGSSSSDSDSGSSSG 
               
               
                   
                   
                 SESDAYAATSPPAGSNTSARG 
               
               
                   
               
               
                 146 
                 The amino acid sequence of SEQ ID 
                 MEGHSGALGFGQGFSRSSQSPNLSPSPSHSASASVTSSG 
               
               
                   
                 412. The conserved GCN5-related N- 
                 QKRKRNEVEHAGVASNSTGMFAVPPSHIYSHLHPMSMSM 
               
               
                   
                 acetyltransferase family domain is 
                 PMPMHNSHPSSLSESRDGALTSNDDDDNLTGGNQSQLDS 
               
               
                   
                 underlined and the bromodomain is 
                 MSAGNTDGREDFDDEDDDDDDEEDDDEVEGDEEDQDHDP 
               
               
                   
                 in bold. 
                 DADDDSDDGHDSMRTFTAARLDNGAPNSRNLKPKADAAG 
               
               
                   
                   
                 VAIAPTVKTEPILDTVKEEKVSGNNNNNSVSANNAQVAP 
               
               
                   
                   
                 SGSAVLLSAVKEEANKPTSTDHIQTSGAYCAREESLKRE 
               
               
                   
                   
                 EDADRLKFVCFGNDGIDQHMIWLIGLKNIFARQLPNMPK 
               
               
                   
                   
                 EYIVRLVMDRSHKS VMIIKQNQVVGGITYRPYLSQKFGE   
               
               
                   
                   
                 
                   IAFCAITADEQVKGYGTRLMNHLKQHARDVDGLTHFLTY 
                 
               
               
                   
                   
                   ADNNAVGYFIKQDFT KEIKLEKERWHGYIKDYDGGILME 
               
               
                   
                   
                 CKIDPKLPYTDLPAMIRWQRQTIDEKIRELSNCHIVYSG 
               
               
                   
                   
                 IDIQKKEAGIPRKPIKVEDIPGLKEAGWTTDQWGHSRFR 
               
               
                   
                   
                 LLNSPSEGLPNRQV LHAFMRSLHKAMVEHADAWPFKEPV   
               
               
                   
                   
                 
                   DPRDVPDYYDIIKDPMDVKRMFTNARTYNTHETIYYKCA 
                 
               
               
                   
                   
                 
                   NR 
                 
               
               
                   
               
               
                 147 
                 The amino acid sequence of SEQ ID 
                 MEESGNSLTSGPDGSK RRVSYFYDSDIGNYYYSQGHPMK   
               
               
                   
                 413. The conserved histone 
                 
                   PHRIRMAHSLIVHYALDEKMEVCRPNLLQSRELRVFHAD 
                 
               
               
                   
                 deacetylase family domain is 
                 
                   DYISFLQSVTPETQHEQLRQLKRFNVGEDCPVFDGLYNF 
                 
               
               
                   
                 underlined. 
                 
                   CQTYAGGSVGAAIKLNNKEADIAINWSGGLHHAKKCEAS 
                 
               
               
                   
                   
                 
                   GFCYVNDIVLAILELLKVHQRVLYIDIDIHHGDGVEEAF 
                 
               
               
                   
                   
                 
                   YSTDRVMSVSFHKFGDYFPGTGHLKDVGYGKGKYYSLNV 
                 
               
               
                   
                   
                 
                   PLNDGIDDESYKNLFRPIIQKVMEIYQPEAVVLQCGADS 
                 
               
               
                   
                   
                 
                   LSGDRLGCFNLSVKGHADCVRFLRSFNVPLVLVGGGGYT 
                 
               
               
                   
                   
                   IRNVARCWCYETAVAVG VEPQDKLPYNEYYEYFGPDYTL 
               
               
                   
                   
                 HVAPSNMENQNSAKELAKIRNTLLEQLKRIQHVPSVPFQ 
               
               
                   
                   
                 ERPPDTKFPEEDEEDYEKRPKGHKWGGEYFGSESDEEQK 
               
               
                   
                   
                 PQNRDIDISDKPGIRRQSPPNVEAAKKIKVEEEDGDIGI 
               
               
                   
                   
                 VNENDGAKWPLGEAG 
               
               
                   
               
               
                 148 
                 The amino acid sequence of SEQ ID 
                 MEESGNSLTSGPDGSK RRVSYFYDSDIGNYYYSQGHPMK   
               
               
                   
                 414. The conserve histone 
                 
                   PHRIRMAHSLIVHYALDEKMEVCRPNLLQSRELRVFHAD 
                 
               
               
                   
                 deacetylase domain is underlined. 
                 
                   DYISFLQSVTPETQHEQLRQLKRFNVGEDCPVFDGLYNF 
                 
               
               
                   
                   
                 
                   CQTYAGGSVGAAIKLNNKEADIAINWSGGLHHAKKCEAS 
                 
               
               
                   
                   
                 
                   GFCYVNDIVLAILELLKVHQRVYIDIDIHHGDGVEEAF 
                 
               
               
                   
                   
                 
                   YSTDRVMSVSFHKFGDYFPGTGHLKDVGYGKGKYYSLNV 
                 
               
               
                   
                   
                 
                   PLNDGIDDESYKNLFRPIIQKVMEIYQPEAVVLQCGADS 
                 
               
               
                   
                   
                 
                   LSGDRLGCFNLSVKGHADCVRFLRSFNVPLVLVGGGGYT 
                 
               
               
                   
                   
                   IRNVARCWCYETAVG VEVEPQDKLPYNEYYEYFGPDYTL 
               
               
                   
                   
                 HVAPSNMENQNSAKELAKIRNTLLEQLKRIQHVPSVPFQ 
               
               
                   
                   
                 ERPPDTKFPEEDEEDYEKRPKGHKWGGEYFGSESDEEQK 
               
               
                   
                   
                 PQNRDIDISDKPGIRRQSPPNVEAAKKIKVEEEDGDIGI 
               
               
                   
                   
                 VNENDGAKWPLGEAG 
               
               
                   
               
               
                 149 
                 The amino acid sequence of SEQ ID 
                 MMETGGNSLPSGPDGVK RKVAYFYDPEVGNYYYGQGHPM   
               
               
                   
                 416. The conserved histone 
                 
                   KPHRIRMTHALLVQYGLHKEMQILKPYPARDRDLCRFHA 
                 
               
               
                   
                 deacetylase family domain is 
                 
                   DDYVAFLRGITPETIQDQVKALKRFNVGDDCPVFDGLYQ 
                 
               
               
                   
                 underlined. 
                 
                   YCQTYAGGSVGGAVKLNHKLCDIAINWAGGLHHAKKCEA 
                 
               
               
                   
                   
                 
                   SGFCYVNDIVLAILELLKYHKRVLYVDIDIHHGDGVEEA 
                 
               
               
                   
                   
                 
                   FYTTDRVMTVSFHKFGDYFPGTGDIRDIGCGKGKYYAVN 
                 
               
               
                   
                   
                 
                   VPLDDGIDDESFQSLFKPIIQQVMLVYNPEAIVLQCGAD 
                 
               
               
                   
                   
                 
                   SLSGDRLGCFNLSVKGHAECVRYMRSFNVPLLMVGGGGY 
                 
               
               
                   
                   
                   TVRNVARCWCYETGVAVG VEIDDKMPQHEYYEYFGPDYT 
               
               
                   
                   
                 VHVAPSNMENKNTKQYLDKIRSKILENINSLPCAPSAQF 
               
               
                   
                   
                 QVQPPDTDFPELEEEDYDERTRSHKWDGASCDSDSENGD 
               
               
                   
                   
                 LKHRNHDVEESAFPRHNLANISYNTKIKLEGVGTGGLDM 
               
               
                   
                   
                 AAGTDTKKNDESFEAMDYESGEELRQDHFASTINASQPC 
               
               
                   
                   
                 DPALLTGVQNQLQSTDTVKPIEQSGNAPGIPPPSVATVS 
               
               
                   
                   
                 TGTRPSSISRTSSLNSMSSVKQGSILGPNPPQGLNASGL 
               
               
                   
                   
                 QFPVPTSNSPIRQGGSYSITVQAPDKQGLQNHMKGPQNM 
               
               
                   
                   
                 PGNS 
               
               
                   
               
               
                 150 
                 The amino acid sequence of SEQ ID 
                 MPPK DRVAYFYDGDVGSVYFGPNHPMKPHRLCMTHHLVL   
               
               
                   
                 417. The conserved histone 
                 
                   SYELHKKMEIYRPHKAYPVELAQFHSADYVEFLHRITPD 
                 
               
               
                   
                 deacetylase family domain is 
                 
                   TQHLFTKELVKYNMGEDCPVFENLFEFCQIYAGGTIDAA 
                 
               
               
                   
                 underlined. 
                 
                   HRLNNQICDIAINWSGGLHHAKKCEASGFCYINDLVLGI 
                 
               
               
                   
                   
                 
                   LELLKHHARVLYVDIDVHHGDGVEEAFYFTDRVMTVSFH 
                 
               
               
                   
                   
                 
                   KYGDMFFPGTGDVKEVGEREGKYYAINVPLKDGIDDASF 
                 
               
               
                   
                   
                 
                   TRLFKTIITKVVDIYQPGAIVLQCGADSLAGDRLGCFNL 
                 
               
               
                   
                   
                 
                   SIDGHAQCVRIVKKFNLPLLVTGGGGYTKENVARCWSVE 
                 
               
               
                   
                   
                   TGVLLD TELPNEIPDNDYIKYFAPDYSLKINTAGNMENL 
               
               
                   
                   
                 NSKTYLSAIKVQVMENLRAIQHAPSVQMHEVPPDFYIPD 
               
               
                   
                   
                 IDEDELNPDERMDQHTQDRQIQRDDEYYDGDNDIDHDME 
               
               
                   
                   
                 EAS 
               
               
                   
               
               
                 151 
                 The amino acid sequence of SEQ ID 
                 MDSSKSEEANILHVFWHEGMLNHD LGTGVFDTLEDPGFL   
               
               
                   
                 418. The conserved histone 
                 
                   EVLEKHPENADRVRNMLSILRKGPIAPYTEWHTGRAAYL 
                 
               
               
                   
                 deacetylase family domain is 
                 
                   SELYSFHRPDYVDMLAKTSTAGGKTLCHGTRLNPGSWEA 
                 
               
               
                   
                 underlined. 
                 
                   ALLAAGTTLEAMRYILDGHGKLSYALVRPPGHHAQPTQA 
                 
               
               
                   
                   
                 
                   DGYCFLNNAGLAVELAVASGCKRVAVVDIDVHYGNGTAE 
                 
               
               
                   
                   
                 
                   GFYERDDVLTISLHMNHGSWGPSHPQTGFHDEVGRGKGL 
                 
               
               
                   
                   
                 
                   GFNLNVPLPNGTGDKGYEHAMHELVVPAISKFMPEMIVL 
                 
               
               
                   
                   
                 
                   VIGQDSSAFDPNGRECLTMEGYRKIGQIMRQQADQFSGG 
                 
               
               
                   
                   
                   RLVVVQEGGYHITYAAYCLHATLEGVLC LPHPLLSDPIA 
               
               
                   
                   
                 YYPEHDIYSERVTFIKNYWQGGIISTTDKRN 
               
               
                   
               
               
                 152 
                 The amino acid sequence of SEQ ID 
                 MEESGNALVSGPDGSK RRVTYFYDADIGNYYYGQGHPMK   
               
               
                   
                 419. The conserved histone 
                 
                   PHRMRMAHNLIVHYGLHQRMEVCRPHLAQSKDIRAFHTD 
                 
               
               
                   
                 deacetylase family domain is 
                 
                   DYIHFLSSVAPDTQQEQLRQLKRFNVGEDCPVFDGLFNF 
                 
               
               
                   
                 underlined. 
                 
                   CQSSAGGSIGAALKLNRKDADIAINWAGGLHHAKKCEAS 
                 
               
               
                   
                   
                 
                   GFCYVNDIVLGILELLKVHQRVLYIDIDIHHGDGVEEAF 
                 
               
               
                   
                   
                 
                   YTTDRVMTVSFHKFGDYFPGTGHIKDVGYGKGKYYALNV 
                 
               
               
                   
                   
                 
                   PLNDGIDDESYKHLFRPIIQKVMEVYQPEAVVLQCGADS 
                 
               
               
                   
                   
                 
                   LSGDRLGCFNLSVKGHADCVRFVRSFNIPLMLVGGGGYT 
                 
               
               
                   
                   
                   IRNVARCWCYETAVAVG VEPQDKLPYNEYYEYFGPDYTL 
               
               
                   
                   
                 YVAPSNMENLNTEKDLEKMRNVLLEQLSKIQHTPSVPFQ 
               
               
                   
                   
                 ERPPDTEFNDEEEEDMEKRSKCRIWDGEYVGSEPEEDGK 
               
               
                   
                   
                 LPRFDADTYERSVLKHENKRLVPVSNVEPLKRIKQEEDG 
               
               
                   
                   
                 AAV 
               
               
                   
               
               
                 153 
                 The amino acid sequence of SEQ ID 
                 MDLNLVSHGEEEEGVRR RKVGIVYDERMCKHATPEDQPH   
               
               
                   
                 421. The conserved histone 
                 
                   PEQPDRIRVIWDKLNSAGVLHKCVMVEAKEASEEQLAGV 
                 
               
               
                   
                 deacetylase family domain is 
                 
                   HSRKHIEVMKSIGTARYNKKKRDKLAASYSSIYFSQGSS 
                 
               
               
                   
                 underlined. 
                 
                   EAALLAAGSVVEISEKVASGELDAGVAIVRPPGHHAEAD 
                 
               
               
                   
                   
                 
                   KAMGFCLFNNIAIAAKHLVHERPELGVQKVLIVDWDVHH 
                 
               
               
                   
                   
                 
                   GNGTQHMFWTDPHVLYFSVHRFDAGTFYPGGDDGFYDKI 
                 
               
               
                   
                   
                 
                   GEGKGAGYNINVPWEQGKCGDADYLAVWDHVLVPVAKSY 
                 
               
               
                   
                   
                 
                   DPDMVLISGGFDAALGDPLGGCRLTPYGYSLMTKKLMEF 
                 
               
               
                   
                   
                   AGGKIVLALEGGYNLKSLADSFLACVEALLK DGPGRSSV 
               
               
                   
                   
                 LTHPFGSTWRVIQAVRKELSSFWPALNEELQLPRLLKDA 
               
               
                   
                   
                 SESFDKLSSSSSDESSASEDEKKFAEVTSIMEVSPDPSS 
               
               
                   
                   
                 ILALTAEDIAQPLAGLKIEEAGTDSQRSSDHTLLDLTND 
               
               
                   
                   
                 DTQKLKQFEGEIFVMIGDEESVPSASSSKDQNESTVVLS 
               
               
                   
                   
                 KSNIKAHSWRLTFSSIYVWYASYGSNMWNPRFLCYIEGG 
               
               
                   
                   
                 QVEGMAKRCCGSEDKLLLKGYSGKLFLIECFLGDHTQIH 
               
               
                   
                   
                 GVQEECPFLIQIVVIRVKRMSACIK 
               
               
                   
               
               
                 154 
                 The amino acid sequence of SEQ ID 
                 MADEDLDLSDVGEVEDEPGEEIESTPPLAVGQEKEINSL 
               
               
                   
                 422. The conserved FKBP-type 
                 ALKKKLLKV GTRWETPENGDE VTVHYTGTLPDGTKFDSS     
               
               
                   
                 peptidyl-prolyl cis-trans 
                 
                   RDRGEPFTFKLGQGQ VIKGWDQGIVTMKKGERALFTIPP   
                 
               
               
                   
                 isomerase signature is underlined 
                     ELAYG SSGVRPTIPPNATLQFDVELL SWTNIVDVCNDGG 
               
               
                   
                 and the FKBP-type peptidyl-prolyl 
                 ILKRIISE GEKYERPKDPDEVTVKYEAKLEDGTLVAKSP   
               
               
                   
                 cis-trans isomerase signatures 1 
                 
                   EEGVEFYVNDGHFCPAIAKAVKTMKRGESVILTIKPTYA 
                 
               
               
                   
                 and 2 are in bold. 
                   FGERGKDAEEGFAAIPPNATLTTSLELV SFKAVIAVTED 
               
               
                   
                   
                 KKVIKKILKE ADGYDKPSDGTVVQIRYTAKLQDGTIFEK   
               
               
                   
                   
                 
                   KGYEGEEPFQFVVDEEQVIAGLDKAVETMKTGEIALITI 
                 
               
               
                   
                   
                   GAEYGFGNFETQRDLAVIPPNSTLIYEVEMI SFTKEKES 
               
               
                   
                   
                 WDMDTTEKIEASKQKKEQGNSLFKVGKYQRAAKKYEKAA 
               
               
                   
                   
                 KYIEHDSSFSAEEKKQSKVLKVSCNLNHAACRLKLKDFK 
               
               
                   
                   
                 EAVKLCSKVLELESQNVKALYRRAQAYIETADLDLAEFD 
               
               
                   
                   
                 IKKALEIEPQNREVQLEYKILKQKQIEYNKKDAKLYGNM 
               
               
                   
                   
                 FAKLNKLEAFEGKVLS 
               
               
                   
               
               
                 155 
                 The amino acid sequence of SEQ ID 
                 MADEGLELSDVAEVEDEPGEEFESAPPLVVGQEKELNSS 
               
               
                   
                 423. The conserved FKBP-type 
                 GLKKKLLKAG TRCETPENGDEVT VHYTGTLLDGTKF DSS   
               
               
                   
                 peptidyl-prolyl cis-trans 
                 
                   RDRGEPFTFNIGQGQVIKGWDQGIVTMKKREHALFTIPP 
                 
               
               
                   
                 isomerase family domains are 
                   ELAYGASGMPPTIPPNATLQFDVELL SWTNIVDVCKDGG 
               
               
                   
                 underlined. The FKBP-type 
                 ILKRIISD GEKYERPKDPDEVTVKYEAKLEDGMLVAKSP   
               
               
                   
                 peptidyl-prolyl cis-trans 
                 
                   EEGVEFYVNDGNFCPAIVKAVKTMKKGENVTLTIKPAYA 
                 
               
               
                   
                 isomerase signatures 1 and 2 are 
                   FGEQGKDAEEGFAAIPPNATITINLQLV SFKAVKEVTED 
               
               
                   
                 in bold. The TPR repeat is in 
                 KKVIKKILKE ADGYDKPSDGTVVQIRYTAKLQDGTIFEK   
               
               
                   
                 bold/italics. 
                 
                   KGYAGEEPFQFVVDEEQ VIAGLDKAVETMKTGEVALITI   
                 
               
               
                   
                   
                     GPEYGFG NIETQRDLAVIPPYSTLIYEVEMV SFTKEKES 
               
               
                   
                   
                 WDMNTTENIEASKQKKEQGNSLFKVGKYLRAAKKYDKAA 
               
               
                   
                   
                 KYIEHDNSFSAEEKKQSKVLKVSCNLNHAACCLKLKDFK 
               
               
                   
                   
                 KAVKLCSKVLELESQN   
               
               
                   
                   
                    REVRLEYLILKQKQIEYNKKDAKLYGNM 
               
               
                   
                   
                 FARQNKLEAIEGKD 
               
               
                   
               
               
                 156 
                 The amino acid sequence of SEQ ID 
                 MPNP KVFFDMQVGGAPAGRIVMELYADVVPKTAENFRAL   
               
               
                   
                 424. The conserved cyclophilin- 
                 
                   CTGEKGTGRSGKPLH FKGSSFHRVIPGFMCQGG DFTRGN 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   GTGGESIYGEKFADENFVKKHTGPGILSMANAGPNTNGS 
                 
               
               
                   
                 isomerase signature is underlined 
                 
                   QFFICTAQTSWLDGKHVVFGQVVEGLEVVRDIEKVGSGS 
                 
               
               
                   
                 and the cyclophilin-type peptidyl- 
                 
                   GRTSKPVVIADSGQLA 
                 
               
               
                   
                 prolyl cis-trans isomerase 
               
               
                   
                 signature 2 is in bold. 
               
               
                   
               
               
                 157 
                 The amino acid sequence of SEQ ID 
                 MPNP KVFFDMQVGGAPAGRIVMELYADVVPKTAENFRAL   
               
               
                   
                 425. The conserved cyclophilin- 
                 
                   CTGEKGNGRSGKPLH FKGSSFHRVIPGFMCQGG DFTRGN 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   GTGGESIYGEKFADENFVKKHTGPGILSMANAGPNTNGS 
                 
               
               
                   
                 isomerase signature is underlined 
                 
                   QFFICTAQTSWLDGKHVVFGQVVEGLEVVRDIEKVGSGS 
                 
               
               
                   
                 and The cyclophilin-type peptidyl- 
                 
                   GRTSKPVVIADSGQLA 
                 
               
               
                   
                 prolyl cis-trans isomerase 
               
               
                   
                 signature 2 is in bold. 
               
               
                   
               
               
                 158 
                 The amino acid sequence of SEQ ID 
                 MPNP KVFFDMQVGGAPAGRIVMELYADVVPKTAENFRAL   
               
               
                   
                 426. The conserved cyclophilin- 
                 
                   CTGEKGTGRSGKPLH FKGSSFHRVIPGFMCQGG DFTRGN 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   GTGGESIYGEKFADENFVKKHTGPGILSMANAGPNTNGS 
                 
               
               
                   
                 isomerase signature is underlined 
                 
                   QFFICTAQTSWLDGKHVVFGQVVEGLEVVRDIEKVGSGS 
                 
               
               
                   
                 and The cyclophilin-type peptidyl- 
                 
                   GRTSKPVVIADSGQLA 
                 
               
               
                   
                 prolyl cis-trans isomerase 
               
               
                   
                 signature 2 is in bold. 
               
               
                   
               
               
                 159 
                 The amino acid sequence of SEQ ID 
                 MPNP KVFFDMQVGGAPAGRIVMELYADVVPKTAENFRAL   
               
               
                   
                 427. The conserved cyclophilin- 
                 
                   CTGEKGTGRSGKPLH FKGSSFHRVIPGFMCQGG DFTRGN 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   GTGGESIYGEKFADENFVKKHTGPGILSMANAGPNTNGS 
                 
               
               
                   
                 isomerase signature is underlined 
                 
                   QFFICTAQTSWLDGKHVVFGQVVEGLEVVRDIEKVGSGS 
                 
               
               
                   
                 and The cyclophilin-type peptidyl- 
                 
                   GRTSKPVVIADSGQLA 
                 
               
               
                   
                 prolyl cis-trans isomerase 
               
               
                   
                 signature 2 is in bold. 
               
               
                   
               
               
                 160 
                 The amino acid sequence of SEQ ID 
                 MADDFELPESAGMMENEDFGDTVFKVGEEKEIGKQGLKK 
               
               
                   
                 428. The conserved FKBP-type 
                 LLVKE GGSWETPETGDEVE VHYTGTLLDGTKFDS SRDRG   
               
               
                   
                 peptidyl-prolyl cis-trans 
                 
                   TPFKFKLGQGQVIKGWDQGIATMKKGENAVFTIPPDLAY 
                 
               
               
                   
                 isomerase signature is underlined 
                   GESGSQPTIPPNATLKFDVELL SWASVKDICKDGGIFKK 
               
               
                   
                 and the FKBP-type peptidyl-prolyl 
                 IIKE GEKWEHPKEADEVLVKYEARLEDGTVVSKSEEGVE   
               
               
                   
                 cis-trans isomerase signature 1 is 
                 
                   FYVKDGYFCPAFAIAVKTMKKGEKVLLTVKPQYGFGHQG 
                 
               
               
                   
                 in bold and underlined. The TPR 
                   REAIGNDVARSTNATLLVDLELV SWKVVDEVTDDKKVLK 
               
               
                   
                 repeat is in bold/italics. 
                 KILKQ GEGYERPNDGAVVKVKYTGKLEDGTIFEEKGSDE   
               
               
                   
                   
                 
                   EPFEFMAGEEQVVDGLDRAVMTMKKGEVALVSVAAEYGY 
                 
               
               
                   
                   
                   QTEIKTDLAVVPPKSTLIYEVELV SFVKEKESWDMNTAE 
               
               
                   
                   
                 KIEAAGKKKEEGNALFKVGKYFRASKKYEKATKYIEYDT 
               
               
                   
                   
                 SFSEEEKKQSKPLK   
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                    RDVKLEYRALKEKQKEYNKKEAKFYGNMFARMSKL 
               
               
                   
                   
                 EELESRKSGSQKVETANKEEGSDAMAVDGESA 
               
               
                   
               
               
                 161 
                 The amino acid sequence of SEQ ID 
                 MAASLTPLGAGLAYATIYDQAKVRKLEPTKRSLIALCQH 
               
               
                   
                 429. The conserved FKBP-type 
                 SDSQHRRFITRKYHVNVQILNRRDAIRLIGLAAGLCIDL 
               
               
                   
                 peptidylprolyl isomerase domain is 
                 SLMYDARGAGLPPQENAKLCDTTCEKELENAPMITTESG 
               
               
                   
                 underlined. 
                 LQYKDIKI GNGPSPPIGFQVAANYVAMVPSGQVFDSSLD   
               
               
                   
                   
                 
                   KGQPYIFRVGSGQVIKGLDEGLLSMKVGGKRRLYIPGPL 
                 
               
               
                   
                   
                   AFPKGLNSAPGRPRVAPSSPVIFDVSLE FIPGLESEEE 
               
               
                   
               
               
                 162 
                 The amino acid sequence of SEQ ID 
                 MSAASLSADMAIRGTILGKTALHVLGPQVVSQCRQPVMF 
               
               
                   
                 430. The conserved FKBP-type 
                 KCPPHTLRKMRFSAQDLQSKNFYSGFTPFKSVFISTSKR 
               
               
                   
                 peptidylprolyl isomerase domain is 
                 SWQAGSARAMSQDAAFQSKVTT KCFLDIEIGGDPAGRIV   
               
               
                   
                 underlined and the Cyclophilin- 
                 
                   LGLFGEDVPKTAENFRALCTGEKGFG YKGSSFHRIIKDF   
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                     MLQGG DFDRGDGTGGKSIYGRTFEDENFKLAHVGPGVLS 
                 
               
               
                   
                 isomerase signature is in bold. 
                 
                   MANAGPNTNGSQFFICTVKTPWLDKRHVVFGQVIEGMEI 
                 
               
               
                   
                   
                 
                   VKKLESEETNRTDRPKRPCRIVDCGELP 
                 
               
               
                   
               
               
                 163 
                 The amino acid sequence of SEQ ID 
                 MGRIKPQTLLQQSKKKKVPGRISVSTIIVCNLIIIFLMF 
               
               
                   
                 431. The conserved FKBP-type 
                 SLVGIYRQRAKRNRATSRSDGDEEMENFGRSKINSVP HQ   
               
               
                   
                 peptidylprolyl isomerase domain is 
                 
                   AIVNTTKGLITLELFGKSSAHTVEKFVEWSERGYFNGLP 
                 
               
               
                   
                 underlined. 
                 
                   FYRVIKHFVIQVGDPKFAGNREDWTVGGQLNVQLEFSPK 
                 
               
               
                   
                   
                 
                   HEAFMLGTSKLEDQGDGFELFITTAPIPDLNDKLNVFGR 
                 
               
               
                   
                   
                   VIKGQDVVQEIEEVDTDEHFQPKSPIIINDVRLKD EL 
               
               
                   
               
               
                 164 
                 The amino acid sequence of SEQ ID 
                 MARQSTLLLFWSLVFLGAIVFTQAKHEELEEVTH KVYFD   
               
               
                   
                 432. The conserved cyclophilin- 
                 
                   VDIAGKPAGRVVIGLFGKAVPKTVENFRALCTGEKGVGK 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   SGKPLH YKGSFFHRIIPSFMIQGG DFTLGDGRGGESIYG 
                 
               
               
                   
                 isomerase signature is underlined 
                 
                   TKFADENFKLKHTGPVFITTVTTDWLDGRHVVFGKIISG 
                 
               
               
                   
                 and the cyclophilin-type peptidyl- 
                   MDVVYKVEAEGRQSGQPKRKVKIADSGELS MD 
               
               
                   
                 prolyl cis-trans isomerase 
               
               
                   
                 signature is in bold. 
               
               
                   
               
               
                 165 
                 The amino acid sequence of SEQ ID 
                 MEMDEIQEQSQPQSSEKQDISQESDTGNDKTINAEKITS 
               
               
                   
                 434. The conserved FKBP-type 
                 ENAEVEEDDMLPPKVNTEVEVLHDKVTKQIIKE GSGNKP   
               
               
                   
                 peptidyl-prolyl cis-trans 
                 
                   SRNSTCFLHYRAWAESTMHKFQDTWQEQQPLELVLGREK 
                 
               
               
                   
                 isomerase signature is underlined 
                 
                   KELSGFAIGVAGMKAGERALLHVDWQLGYGEEGNFSFPN 
                 
               
               
                   
                 and the TPR repeat is in bold. 
                   VPPRANLIYEAELI GFEEAKEGKARSDMTVEERIEAADR 
               
               
                   
                   
                 RRQQGNELFKEDKLAEAMQQYEMALAYMGDDFMFQLFGK 
               
               
                   
                   
                 YKDMANAVKNPCHLNMAQCLLKLNRYEEAIGQCNMVLAE 
               
               
                   
                   
                 DEKN IKALFRRGKARATLGQTDDAREDFQKVRKFSPED K 
               
               
                   
                   
                 AVIRELRLLAEHDKQVYQKQKEMFKGLFGQKPEQKPKKL 
               
               
                   
                   
                 HWFVVFWQWLLSMIRTIFRMRSKTD 
               
               
                   
               
               
                 166 
                 The amino acid sequence of SEQ ID 
                 MAGAGEG TPEVTLETSMGPITVELYHKHAPKTCRNFLEL   
               
               
                   
                 435. The conserved cyclophilin- 
                 
                   SRRGY YNNVKFHRVIKDFMVQGG DPTGTGRGGESIYGPR 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   FEDEITRDLKHTGAGILSMANAGPNTNGSQFFISLAPTP 
                 
               
               
                   
                 isomerase signature is underlined 
                 
                   WLDEKHTIFGRVCKGMDVVKRLGNVQTDKNDRPIHDVKI 
                 
               
               
                   
                 and the cyclophilin-type peptidyl- 
                 
                   LRTTVKD 
                 
               
               
                   
                 prolyl cis-trans isomerase 
               
               
                   
                 signature is in bold. 
               
               
                   
               
               
                 167 
                 The amino acid sequence of SEQ ID 
                 MMDPELMRLAQEQMSKISPDELMKMQRQIMANPDLMRMA 
               
               
                   
                 436. The conserved TPR repeat 
                 SENMKNLKPEDIRFAAEQMKNVRKEEMAEISERISRASP 
               
               
                   
                 domain is underlined. 
                 EEIEAMKARANLQSAYQLQVAQNLKDQGNQLHARMKYSE 
               
               
                   
                   
                 AAEKYLQARNNLTGIPFSEAKSLLLASSSNLMSCYLKTG 
               
               
                   
                   
                 QYEECVQTGSEVLAYDAMN VKALYRRGQAYKQIGKLELA   
               
               
                   
                   
                   VADLRKAVEVSPED ETIAQALREASTELMEKGGTQDQNG 
               
               
                   
                   
                 PRIEEIIEEEAVQPTAEKYPQSAPMVTSVTEDVSDDEQG 
               
               
                   
                   
                 SEDQNGFSRDSFQATNAPDGQMYAESLRNLTENPDMLRT 
               
               
                   
                   
                 MQSLMKNVDPDSLVALSGGKLSPDMVKTVSGMFGRMSPE 
               
               
                   
                   
                 EIQNMMKMSSTLSRQNPSTSSRFDDITRGHSNMDSSPQS 
               
               
                   
                   
                 VSVDNDLFEENQNRVGESSTNLSSSAAFSGMPNFSAEMQ 
               
               
                   
                   
                 EQVRNQMNDPATRQMFTSMIQNMSPEMMASMSEQFGVKL 
               
               
                   
                   
                 SPEDAVKAQNAMASLSPNDLDRLMNWATRLQTAIDYARK 
               
               
                   
                   
                 IKNWILGRPGLIFAISMLLLAIILHRFGYIGD 
               
               
                   
               
               
                 168 
                 The amino acid sequence of SEQ ID 
                 MGVEKEILRP GNGPKPRPGQSVTVHCTGYGKNEDLSQKF   
               
               
                   
                 437. The conserved FKBP-type 
                 
                   WSTKDPGQKPFTFTIGQGR VIKGWDEGVLDMQLGEIFKL   
                 
               
               
                   
                 peptidylprolyl isomerase domain is 
                     RCSPDYGYG SNGFPAWGIRPNSVLVFEIEVL SVN 
               
               
                   
                 underlined and the Cyclophilin- 
               
               
                   
                 type peptidyl-prolyl cis-trans 
               
               
                   
                 isomerase signature is in bold. 
               
               
                   
               
               
                 169 
                 The amino acid sequence of SEQ ID 
                 MPNP RCYLDITIGEELEGRILVELYSDVVPKTAENFRAL   
               
               
                   
                 438. The conserved cyclophilin- 
                 
                   CTGEKGIGPHTGVPLH YKGLPFHRVIKGFMIQGG DISAQ 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   NGTGGESIYGLKFDDENFQLKHERRGMLSMANSGPNTNG 
                 
               
               
                   
                 isomerase family domain is 
                 
                   SQFFITTTRTSHLDGKHVVFGKVIKGMGVVRGIEHTPTE 
                 
               
               
                   
                 underlined and the cyclophilin- 
                   SNDRPSLDVVISDCGEIP EGSDDGIANFFKDGDLYPDWP 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 ADLDEKSAEISWWMNAVDSAKCFGNENYKKGDYKMALRK 
               
               
                   
                 isomerase signature is in bold. 
                 YRKALRYLDICWEKEEIDEEKSNHLRKTKSQIFTNSSAC 
               
               
                   
                   
                 KLKLGDLKGALLDTEFAMRDGEDNVKALFRQGQAYMALK 
               
               
                   
                   
                 DVDSAVASFKKALQLEPNDAGIRKELAVATKMINDRRDQ 
               
               
                   
                   
                 ERRAYARMFQ 
               
               
                   
               
               
                 170 
                 The amino acid sequence of SEQ ID 
                 MGDVIDLNGDGGVLKTIIRSAKP GAMQPTEDLPNVDVHY   
               
               
                   
                 439. The conserved FKBP-type 
                 
                   EGTLADTGEVFDTTREDNTLFSFELGKGT VIKAWDIAVK   
                 
               
               
                   
                 peptidylprolyl isomerase domain is 
                 
                     TMKVGEVARITCKPEYAYG SAGSPPDIPENATLIFEVEL 
                 
               
               
                   
                 underlined and the Cyclophilin- 
                   V ACKPRKGSTFGSVSDEKARLEELKKQREIAAASKEEEK 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 KRREEAKATAAARVQAKLEAKKGQGRGKGKSKGK 
               
               
                   
                 isomerase signature is in bold. 
               
               
                   
               
               
                 171 
                 The amino acid sequence of SEQ ID 
                 MGLGLKIASASFLPIFNIMATRSLCILLVCFIPVLAHVL 
               
               
                   
                 440. The conserved cyclophilin- 
                 SLQDPELGTV RVYFQTTYGDIEFGFFPHVAPKTVEHIYK   
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                   LVRLGCYNSNHFFRVDKGFVAQVADVVGGREVPLNSEQR 
                 
               
               
                   
                 isomerase signature is underlined. 
                 
                   KEGEKTIVGEFSEVKHVRGILSMGRYSDPDSASSSFSIL 
                 
               
               
                   
                   
                 
                   LGNAPHLDGQYAVFGKVTKGDDTLKRLEEVPTRQEGIFV 
                 
               
               
                   
                   
                   MPLERIRILSTYYYD TNERESNLTCDHEVSILKRRLVES 
               
               
                   
                   
                 AYEIEYQRRKCLP 
               
               
                   
               
               
                 172 
                 The amino acid sequence of SEQ ID 
                 MASKRSLRTMNVWPTLPPLVLLLLLCFSSMSSSVVAKKS 
               
               
                   
                 441. The conserved FKBP-type 
                 DVSELQIGVKHKP KSCDIQAHKGDRIK VHYRGSLTDGTV     
               
               
                   
                 peptidylprolyl isomerase domain is 
                 
                     FDSS FERGDPIEFELGSGQ VIKGWDQGLLGMCVGEKRKL   
                 
               
               
                   
                 underlined and the Cyclophilin- 
                     RIPSKLGYG AQGSPPKIPGGATLIFDTELV AVNGKGISN 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 DGDSDL 
               
               
                   
                 isomerase signatures are in bold. 
               
               
                   
               
               
                 173 
                 The amino acid sequence of SEQ ID 
                 MSGAPAERP ISYFDITIGGKPIGRIVFSLYADLVPKTAE   
               
               
                   
                 442. The conserved FKBP-type 
                 
                   NFRALCTGEKGIGKSGKPLC YAGSGFHRVIKGFMCQGG D 
                 
               
               
                   
                 peptidylprolyl isomerase domain is 
                 
                   FTAGNGTGGESIYGEKFEDEAFPVKHTKPFLLSMANAGK 
                 
               
               
                   
                 underlined and the Cyclophilin- 
                 
                   DTNGSQFFITVSQTPHLDDKHVVFGEVIKGKSIVRAIEN 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                   YPTASGDVPTSPIIISACGVLS PDDPSLAASEETIGDSY 
               
               
                   
                 isomerase signatures are in bold. 
                 EDYPEDDDSDVQNPEVALDIARKIRELGNKLFKEGQIEL 
               
               
                   
                   
                 ALKKYLKSIRYLDVHPVLPDDSPPELKDSYDALLAPLLL 
               
               
                   
                   
                 NSALAALRTQPADAQTAVKNATRALERLELSDADKAKAL 
               
               
                   
                   
                 YRRASAHVILKQEDEAEEDLVAASQLSPEDMAISSKLKE 
               
               
                   
                   
                 VKDEKKKKREKEKKAFKKMFSS 
               
               
                   
               
               
                 174 
                 The amino acid sequence of SEQ ID 
                 MASSLRSSLFSSWALDSKSVCSLFNLNPGKMGLPSISTP 
               
               
                   
                 443. The conserved FKBP-type 
                 LNWRTCCCSHSSELLELNEGLQSSRRKTVMGLSTVIALS 
               
               
                   
                 peptidylprolyl isomerase domain is 
                 LVYCDEVGAVSTSKRALRSQKVPEDEYTTLPNGLKYYDL 
               
               
                   
                 underlined. 
                 KV GSGTEAVKGSRVAVHYVAKWKGITFMTSRQGMGITGG   
               
               
                   
                   
                 
                   TPYGFDVGASERGAVLKGLDLGVQGMRVGGQRILIVPPE 
                 
               
               
                   
                   
                   LAYGNTGIQEIPPNATLEFDVELI SIKQSPFGSSVKIVEG 
               
               
                   
               
               
                 175 
                 The amino acid sequence of SEQ ID 
                 MGAIEDEEPPLKRLKVSSPGLRRGLEEEAPSLSVGSVSI 
               
               
                   
                 444. The conserved G-protein beta 
                 LMAKSLSLEEGETVGSKGLIRRVEFVRIITQALYSLGYQ 
               
               
                   
                 WD-40 repeat domains are 
                 KAGALLEEESGILLQSSNVALFRKQILDGKWDESVVTLR 
               
               
                   
                 underlined. 
                 GIDQVEVEGNTLKAASFLILQQKFFELLDKGNIPEAMKT 
               
               
                   
                   
                 LRLEISPMQLNTKRVHELASCIVFPSRCEELGYSKQGNP 
               
               
                   
                   
                 KSSQRMKVLQEIQQLLPPSIMIPEKRLERLVEQALNVQR 
               
               
                   
                   
                 EACIFHNSLDPALSLYTDHQCGRDQIP TTTLQVLESHKN   
               
               
                   
                   
                   EVWFLQFSNNGKYLASASKDCSAIIWE ITEGDS FSMKHR   
               
               
                   
                   
                   LSAHQKPVSFVAWSPDDKLLLTCGIEEVVKLWN VET GEC   
               
               
                   
                   
                   KLTYDKANSGFTSCGWFPDGERFISGGVDKCIYIWD LEG 
               
               
                   
                   
                 KELDSWKGQGMPKISDLAVTSDGKEIISICGDNAIVMYN 
               
               
                   
                   
                 LDTKTERLIEEESGITSLCVSKDSRFLLLNLANQEIHLW 
               
               
                   
                   
                 DIGARSKLLLKYKSHRQSRYVIRSCFSSSDLAFVVSGSE 
               
               
                   
                   
                 DSQVYIWHRGN GELLAVLPGHSGTVNCVSWNPVNPHVFA   
               
               
                   
                   
                   SASDDYTIRIWG VNRNTFRSKNASSSNGVVHLANGGP 
               
               
                   
               
               
                 176 
                 The amino acid sequence of SEQ ID 
                 MPGTTAGAGIEPTEPQSLKKLSLKSLKRSFDLFASLHGE 
               
               
                   
                 445. The conserved G-protein beta 
                 PQPPDQRSQRIRIACKVRAEYEVVKNLPTLPQREVGSSV 
               
               
                   
                 WD-40 repeat domains are 
                 SNSNVGETHSSLTTNQAQGFPTDTSGDLSKDEGKEITSI 
               
               
                   
                 underlined and the Trp-Asp (WD) 
                 AVHLQPQTGLIDGKAGAIAGTSTAISSVGSSDRYQPSAA 
               
               
                   
                 repeats signature is in bold. 
                 IMKRLPSKWPRPIWHPPWK NYRVISGHLGWVRSVAFDPG   
               
               
                   
                   
                   NEWFCTGSADRTIKIWE VATGK LKLTLTGHIEQIRGLAV   
               
               
                   
                   
                   SSRHPYLFSAGDDKQVKCWD LEYNK AIRSYHGHLSGVYC   
               
               
                   
                   
                   LALHPTLDILCTGGRDSVCRVWD IRTKA QIFALSGHENT   
               
               
                   
                   
                   VCSVFTQAIDPQ VVTGSHDTTIKLWD     L AAGK TMSTLTYH   
               
               
                   
                   
                   KKSVRAIAKHPFEHTFASASADNIKKFK LPKGEF LHNML   
               
               
                   
                   
                   SQQKTIVNAMAINEDNVLVSAGDNGSLWFWD WKSGHNFQ 
               
               
                   
                   
                 QAQTIV QPGSLDSEAGIYALQYDITGSRLVSCEADKTIK   
               
               
                   
                   
                   MWK EDETATPESHPINFKAPKDIRRF 
               
               
                   
               
               
                 177 
                 The amino acid sequence of SEQ ID 
                 M RPILMKGHERPLTFLKYNRDGDLLFSCAKDHTPTVWY G 
               
               
                   
                 446. The conserved G-protein beta 
                 HNGE RLGTYRGHNGAVWCCDVSRDSTRLITSSADQTAKL   
               
               
                   
                 WD-40 repeat domains are 
                   WN VETGAQLFSFNFESPARAVDLAIGDKLVVITTDPFME 
               
               
                   
                 underlined. 
                 LPSAIHIKRIEKDLSKQTAD SVLTITGIKGRINRAVWGP   
               
               
                   
                   
                   LNSTIISGGEDSVVRIWD SETGKLLR ESDKETGHQKPIT   
               
               
                   
                   
                   SLCKSADGSHFLTGSLDKSARLWD IRTLTLIKTYVTERP 
               
               
                   
                   
                 VNAVAISPLLDHVVIGGGQEASHVTTTDREAGKFEAKFF 
               
               
                   
                   
                 HKILEE EIGGVKGHFGPINSLAFNPDGRSFASGGEDGYV   
               
               
                   
                   
                   RLHH FDPDYFHIKM 
               
               
                   
               
               
                 178 
                 The amino acid sequence of SEQ ID 
                 M RPILMKGHERPLTFLKYNRDGDLLFSCAKDHTPTVWY G 
               
               
                   
                 447. The conserved G-protein beta 
                 HNGE RLGTYRGHNGAVWCCDVSRDSTRLITSSADQTAKL   
               
               
                   
                 WD-40 repeat domains are 
                   WN VETGNQLFSFNFESPARAVDLAIGDKLVVITTDPFME 
               
               
                   
                 underlined. 
                 LPSAIHIKRIEKDLSKQTAD SVLTITGIKGRINRAVWGP   
               
               
                   
                   
                   LNSTIISGGEDSVVRIWD SETGKLLR ESDKETGHQKAIT   
               
               
                   
                   
                   SLCKSADGSHFLTGSLDKSARLWD IRTLTLIKTYVTERP 
               
               
                   
                   
                 VNAVAISPLLDHVVIGGGQEASHVTTTDRRAGKFEAKFF 
               
               
                   
                   
                 HKILEE EIGGVKGHFGPINSLAFNPDGRSFASGGEDGYV   
               
               
                   
                   
                   RLHH FDPDYFHIKM 
               
               
                   
               
               
                 179 
                 The amino acid sequence of SEQ ID 
                 MAENNVGDFIPLDRQEYPSKPAPGAVDSSFWKSF KKKEV   
               
               
                   
                 448. The conserved G-protein beta 
                   SRQIAGVTCINFCPEPPHDFAVTSSTRVHIYD GKSCE LK   
               
               
                   
                 WD-40 repeat domains are 
                   KTITKFKDVAYSGVFRSDGQIIAAGGETGVIQVFN AKSQ 
               
               
                   
                 underlined. 
                 M VLRQLKGHGRPVRVVRYSPQDKLHLLSGGDDSMVKWWD   
               
               
                   
                   
                 ITTQE ELLNLEGHKDYVRCGAASPSSVNLWATGSYDHTV   
               
               
                   
                   
                   RLWD LRNS KTVLQLKHGKPLEDVLFFPSGGLLATAGGNV   
               
               
                   
                   
                   VKVWD ILGGGR PIHTMETHQKTVMAMCISKVPRSGQALG   
               
               
                   
                   
                   DAPSRLVTASLDGYMKVFD LDHFKVTHSARYPAPILSMG 
               
               
                   
                   
                 ISSLCRTMAVGTSSGLLFIRQRKGQIEDKIHSDSSGLQV 
               
               
                   
                   
                 NPVNDEKDSAVLKPNQYRYYLRGRSEKPSEGDYVVKRMA 
               
               
                   
                   
                 KVYFQEYDKDLRHFNHSKALVSALKAADSKGTVAVIEEL 
               
               
                   
                   
                 VARKRLIQTLSILNLDELELLINFLSRFILVPKYSRFLI 
               
               
                   
                   
                 SLTDRVLDARAVDLGKSENLKKQIADLKGIVVQELRVQQ 
               
               
                   
                   
                 SMQELQGIIEPLIRASAR 
               
               
                   
               
               
                 180 
                 The amino acid sequence of SEQ ID 
                 MDVETSSKPTGNKRTYTRLPRQVCVFWQEGRCTRESCNF 
               
               
                   
                 449. The conserved C-x8-C-x5-C-x3- 
                 LHVDEPGSVKRGGATNGFAPKRSYNGSDERDTLAAGPPG 
               
               
                   
                 H type zinc finger is underlined 
                 GSRRNISARWGRGRGGIFISDERQKI   RNKV         NYWLAGN       
               
               
                   
                 and in italics and the conserved 
                     QRGEE         KYL         SF   VMGS DVKFLTQLSGHVKAIRGIAFPSD   
               
               
                   
                 Cys and His residues in bold, The 
                   SGKLYSGGQDKKVIVWD CQTGQGTDIPLNDEVGCLMSEG 
               
               
                   
                 conserved G-protein beta WD-40 
                 PWIFVGLPNAVKAWN ILTSTELSLVGPRGQVHALAVGNG   
               
               
                   
                 repeat domains are underlined and 
                   MLFAGTHDGSILAW KFSPAS NTFEPAASLVGHTQAVVSL   
               
               
                   
                 the Trp-Asp (WD) repeats signature 
                 
                   VSGADRLY SGSMDKTIRVW   
                   DL 
                   GTFQCLQTLRDHTSVVMS 
                 
               
               
                   
                 is in bold (non-italics). 
                   LLCWDQFLLSCSLDNTVKVW VAT SSGALEVTYTHNEEHG   
               
               
                   
                   
                   VLALCGMNDEQAKPVLLCSCNDNTVRLY DL PSFSERGRI   
               
               
                   
                   
                   FSRNEVRTFQIAPGGLFFTGDATGELKVW NWATQKS 
               
               
                   
               
               
                 181 
                 The amino acid sequence of SEQ ID 
                 MSVQELRERHAAATAKVNALRERIKAKRLQLLDTDVATY 
               
               
                   
                 450. The conserved G-protein beta 
                 ASSNGRTPISFSFTDLV CCRTLQGHTGKVYSLDWTSEKN   
               
               
                   
                 WD-40 repeat domains are 
                   RIVSASQDGRLIVWN ALTSQ KTHAIKLPCAWVMTCAFSP   
               
               
                   
                 underlined. 
                   SGQAVACGGLDSVCSIFQ LNNQLDRDGHLP VSRILSGHR   
               
               
                   
                   
                   SYVSSCQYVPDGDTHVITGSGDRTCIQWD VTTGQRIAIF 
               
               
                   
                   
                   GGEFPLGHTADVMSVSISAANPKEFVSGSCDTTTRLWD T 
               
               
                   
                   
                 RIASR AIRTFHGHEADVNTVKFFPDGLRFGSGSDDGTCR   
               
               
                   
                   
                   LFD IRTGHQLQVY RQPPRENQSPTVTAIAFSFSGRLLFA   
               
               
                   
                   
                   GYSNGDCFVWD TILEKVVLN LGELQNTHNGRISCLGLSA   
               
               
                   
                   
                   DGSALCTGSWDKNLKIWA FGGHRKIV 
               
               
                   
               
               
                 182 
                 The amino acid sequence of SEQ ID 
                 MKVKIISRSTDEFTRERSNDLQRVFRNFDPNLHTQARAQ 
               
               
                   
                 451. The conserved G-protein beta 
                 EYVRALNAAKLDKIF AKPFLAAMSGHIDGISAMAKSPRH   
               
               
                   
                 WD-40 repeat domains are 
                   LKSIFSGSVDGDIRLWD IA ARRTVQQFPGHRGAVRGLTV   
               
               
                   
                 underlined. 
                   STEGGRLISCGDDCTVRLWD IPVAGIGESSYGSEN VQKP   
               
               
                   
                   
                   LATYVGKNSFRAVDYQWDSNVFATGGAQVDIWD HD RSEP   
               
               
                   
                   
                 
                   TNSFAWGSDTVISVRFNPAEKDIFATTASDRSIVLYDLR 
                 
               
               
                   
                   
                   MAS PLNKLIMQTRNNAIAWNPREPMNFTAANEDCNCYSY 
               
               
                   
                   
                 DMRR MNISTCVHQDHVSAVMDIDYSPSGREFVTGSYDRT   
               
               
                   
                   
                   VRIFP Y NAGHSREIYHTKRMQRVFCVKFSGDATYVVSGS   
               
               
                   
                   
                   DDANIRLWK AKASEQLGVLLPRERKRHEYLDAVKERFKH 
               
               
                   
                   
                 LPEIKRIERHRHLPKPIYKAALLRHTVNAAAKRKEERKR 
               
               
                   
                   
                 AHSAPGSVVTNPLRKKRIVAQLE 
               
               
                   
               
               
                 183 
                 The amino acid sequence of SEQ ID 
                 MDHYYQDDFDYLVDDEMVDFADDVEDDVRTRRRSDIDSD 
               
               
                   
                 452. The conserved G-protein beta 
                 SENDFDLNNKSPDTTALQAKRGKDIQGIPWNRLNFTREK 
               
               
                   
                 WD-40 repeat domains are 
                 YRETRLQQYKNYENLPRPRRSRNLDKECTNFERGSSFYD 
               
               
                   
                 underlined. 
                 FRHNTRSVKATIVHFQLRNLVWATSKHNVYLMQNYSIMH 
               
               
                   
                   
                 WSSLKQKGEEVLNVAGPIVPSVKHPGSSPQGLTRVQVSA 
               
               
                   
                   
                 MSVKDNLVVAGGFQGELICKYLDKPGVSFCTKISHDENG 
               
               
                   
                   
                 ITNAVEIYNDASGATRLMTANNDLAVRVFDTEKFTVLER 
               
               
                   
                   
                 FSFPWSVNHTSVSPDGKLVAVLGDNADCLLADCKT GKTV   
               
               
                   
                   
                   GTLRGHLDYSFAAAWHPDGYILATGNQDTTCRLWD VRKL 
               
               
                   
                   
                 
                   SSSLAVLKGRMGAIRSIRFSSDGRFMAMAEPADFVHLYD 
                 
               
               
                   
                   
                 TRQNYTKSQEIDLFGEIAGISFSPDTEAFFVGVADRTYG 
               
               
                   
                   
                 SLLEFNRRRMNYYLDSIL 
               
               
                   
               
               
                 184 
                 The amino acid sequence of SEQ ID 
                 MAE ALVLRGTMEGHTDAVTAIATPIDNSDM IVSSSRDKS     
               
               
                   
                 453. The conserved G-protein beta 
                     ILLWN     L TKEPEK YGVPRRRLTGHSHFVQDVVISSDGQFA   
               
               
                   
                 WD-40 repeat domains are 
                   LSGSWDSELRLWD LN TGLTTRRFVGHTKDVLSVAFSIDN   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                 
                   RQ IVSASRDRTIKLWN   
                   T 
                   LGECKYTIQPDAEGHSNWISCV 
                 
               
               
                   
                 repeats signatures are in bold. 
                   RFSPSATNPT IVSCSWDRTVKVWN     L T NCKLRNTLVGHGG   
               
               
                   
                   
                   YVNTAAVSPDGSLCASGGKDGVTMLWD LA EGKRLYSLDA   
               
               
                   
                   
                   GDIIYALCFSPNRYWLCAATQQCVKIWD LESKSIVADLR 
               
               
                   
                   
                 PDF IPNKKAQIPYCTSLSWSADGSTLFSGYTDGKIRVWG   
               
               
                   
                   
                 IGHV 
               
               
                   
               
               
                 185 
                 The amino acid sequence of SEQ ID 
                 MAAIKSTSRSASVAFAPDAPLLAAGTMAGAIDLSFSSLA 
               
               
                   
                 454. The conserved G-protein beta 
                 NLEIFKLDFQSDDP ELPVVGECPSNERLNRLSWGSAGGS   
               
               
                   
                 WD-40 repeat domains are 
                   FGIIAGGLVDGTINIWN PATLINSEDN GDALIARLEQHT   
               
               
                   
                 underlined. 
                   GPVRGLEFNTISTNLLASGAEDGELCIWD LANPTAPTH F   
               
               
                   
                   
                 
                   PPLKGVGSGAQGEISFLAWNRKVQHILASTSYSGTTVVW 
                 
               
               
                   
                   
                   D LR RQKPIISFPDATRRRCSVLQWNPDASTQLIVASDDD   
               
               
                   
                   
                   NSPTLEAWD LRN TISPYKEFVGHSRGVIAMSWCPSDSLF   
               
               
                   
                   
                   LLTCAKDNRTLCWD TG SGEIVCELPAGANWNFDVQWSPK   
               
               
                   
                   
                   IPGILSTSSFDGKIGIHN IEACSRNVSGEVEFGGAIVRG 
               
               
                   
                   
                 GPSALLKAPKWLERPAGVSFGFGGKLASFRPSTVAQAAD 
               
               
                   
                   
                 HRHSEVFIHNLVTEDNLVIRSTEFEAAIADGEKVSLRAL 
               
               
                   
                   
                 CDRKAEESQSDEEKETWNFLRVMFEDEGTARTKLLEHLG 
               
               
                   
                   
                 FKVQSEENGDLQETHSSKIDDIGSEIGKTLTLDDKTEED 
               
               
                   
                   
                 VLPQLKGGQDAAIPQDNGEDFFDNLHSPKEEVSLSHVGN 
               
               
                   
                   
                 DFVGEKDKDMVVNGAEIEHETEDLTEYSDWNEAIQHSLV 
               
               
                   
                   
                 VGDYKGAVLQCLSANRMADALIIAHLGGNSLWEKTRDEY 
               
               
                   
                   
                 LKKAKSSYLKVVSAMVNNDLTGLVNSRPLKSWKETLAML 
               
               
                   
                   
                 CTYSQREEWTVLCDMLASRLIAAGNVMAATLCYICAGNI 
               
               
                   
                   
                 EKTVEIWSRSLKYDYDGRSFVDHLQDVMEKTVVLALATG 
               
               
                   
                   
                 QKRVSPSLSKLVENYAELLASQGLLTTAMEYLKLLGTEE 
               
               
                   
                   
                 SSHELSILRDRLYLSGTDNKVEASSFPFETRQDLTESQY 
               
               
                   
                   
                 NMHQTGFGAPETQKNYQENVHQVLPSGSYTDNYQPTANT 
               
               
                   
                   
                 HYIAGYQPAPQQQPSFQNYFTPASYQPAPSPNVFYPSQV 
               
               
                   
                   
                 SQAEQSNFAPPVNQPPMKTFVPSTPPILRNVDQYQTPSL 
               
               
                   
                   
                 NPQLYQGVSSATVETHPYQTGAPASVSVGTTPGQPSVVP 
               
               
                   
                   
                 NFMVPGPVTAPTVTPRGFMPVTTPTQHPLGSANPPVQPQ 
               
               
                   
                   
                 SPQSSQVQSV 
               
               
                   
               
               
                 186 
                 The amino acid sequence of SEQ ID 
                 MAGAADSQLQTLSERDSTPNF KNLHTREYAAHKKKVHSV   
               
               
                   
                 455. The conserved G-protein beta 
                   AWNCTGTKLASGSVDQTARVWN IEPHGH SKTKDLELKGH   
               
               
                   
                 WD-40 repeat domains are 
                   ADSVDQLCWDPKHSEL LATASGDRTVRLWD     A R SGKCSQQ   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                   VELSGENINITFKPDGTHIAVGNRDDELTIID VR KFKPL   
               
               
                   
                 repeats signature is in bold. 
                   HKRKFSYEVNEIAWNTTGELFFLTTGNGTVEVLS YP SLQ   
               
               
                   
                   
                   VLHTLVAHTAGCYCIAIDPIGRYFAVGSADALVSLWD LS 
               
               
                   
                   
                 
                   EMLCVRTFTKLEWPVRTISFNHDGQYIASASEDLFIDIA 
                 
               
               
                   
                   
                   D VQ TGRTVHQISCRAAMNSVEWNPKYNLLAFAGDDKNKY   
               
               
                   
                   
                   MQD EGVFRVFGFETP 
               
               
                   
               
               
                 187 
                 The amino acid sequence of SEQ ID 
                 MAATSPVGAG SGRELANPPTDGISNLRFSNHSDHLLVSS   
               
               
                   
                 456. The conserved G-protein beta 
                   WDRKVRLYD AS ANSLKGQFVHGGPVLDCCFHDDASGFSG   
               
               
                   
                 WD-40 repeat domains are 
                   SADNTVRRYD F STRKEDILGRHEAPVRCVEYSYAAGQVI   
               
               
                   
                 underlined. 
                   TGSWDKTLKCWD PRGASGQ EKTLVGTYSQLERVYSMSLV   
               
               
                   
                   
                   GHRLVVATAGRHINVYD LRNMSQPEQRRESSLKYQTRCV 
               
               
                   
                   
                 RCYPNGTGFALSSVEGRVAMEFFDLSEAGQAKKY AFKCH   
               
               
                   
                   
                   RKSEAGRDTVYPVNAIAFHPIYGTFATGGCDGYVNVWD G 
               
               
                   
                   
                 NNKKRLYQYSKYPTSIAALSFSRDGRLLAVASSYTFEEG 
               
               
                   
                   
                 EKPHEPDAVFVRSVNEAEVKPKPKVYAAPP 
               
               
                   
               
               
                 188 
                 The amino acid sequence of SEQ ID 
                 MASDDEEGFKNEEAPGVVDEAEVQEGLRACFPLSFGKQE 
               
               
                   
                 457. The conserved G-protein beta 
                 KKQAPLESIHSATKRPEDPRPRRQLGPPRPPPSILAEQE 
               
               
                   
                 WD-40 repeat domains are 
                 DSDRFVGPPRPPQFVRDDNDDGEAEIMIGPPRPPAQYSD 
               
               
                   
                 underlined and the Trp-Asp (WD) 
                 DHDNEETIGPPKPSYLEKGEETDQMVGPSKRGSDDETSG 
               
               
                   
                 repeats signature is in bold. 
                 DSDDGDDAVDFRV PLSNEIVLRGHTKVVSALAIDQTGSR   
               
               
                   
                   
                   VLTGSYDYSVRMYD FQGMTS QLKSFRQLEPAEGHQVRSL   
               
               
                   
                   
                   SWSPTSDRFLCVTGSAQAKIFD RDGLTLGEFVK GDMYLR   
               
               
                   
                   
                 
                   DLKNTKGHISGLTCGEWHPKEKQT ILTCSEDGSLRIWD   
                   V 
                 
               
               
                   
                   
                 ND FNTQKQVIKPKLAKPGRVPVTACAWGRDGKCIAGGVG   
               
               
                   
                   
                   DGSIQVWN LKPGWG SRPDLYVAKGHDDDITGLQFSADGN   
               
               
                   
                   
                   ILLTRSTDETLKVWD LRKAITPLQVFRDLPNNYAQTNVA 
               
               
                   
                   
                 FSPDERLIFTGTSVERDGNSGGLLCFYDRQTLELVLRIG 
               
               
                   
                   
                 VSPVHSVVRCTWHPRHNQVFATVGDKKEGGAHILYDPAL 
               
               
                   
                   
                 SERGALVCVARAPRKKSLDDFEAKPVIHNPHALPLFRDE 
               
               
                   
                   
                 PSRKRQREKARMDPMKSQRPDLPVTGPGFGGRVGSTKGS 
               
               
                   
                   
                 LLTQYLLKEGGLIKETWMEEDPREAILKYADVAAKDPKF 
               
               
                   
                   
                 IAPAYAQTQPETVFAETDSEEEQK 
               
               
                   
               
               
                 189 
                 The amino acid sequence of SEQ ID 
                 MKERGQSHAGQPSVDERYTQWKSLVPVLYDWLANHNLVW 
               
               
                   
                 458. The conserved G-protein beta 
                 PSLSCRWGPQMHQATYKNSQRLYLSEQTDGTVPNTLVIA 
               
               
                   
                 WD-40 repeat domains are 
                 TCEVVKPRVAAAEHISQFNEEARSPFVKKFKTIIHPGEV 
               
               
                   
                 underlined. 
                 NRIRELPQNSKIVATHTDGPDVLIWDVDTQPNRQATLGA 
               
               
                   
                   
                 ADSRPDLVLTGHKDNAEFALAMSPSAPFVLSGGKDKCVL 
               
               
                   
                   
                 LWSIQDHISAATEPSSAKASKTPSSAHGEKVPKIPS IGP   
               
               
                   
                   
                   RGVYKGHKDTVEDVQFCPSNAQEFCSVGDDSALILWD AR 
               
               
                   
                   
                 NGN EPVIKVEKAHNADLHCVDWNPHDENLILTGSADNSV   
               
               
                   
                   
                   RMFD RRNLTSSGV GSPVHKFEGHSAPVLCVQWCPDKASV   
               
               
                   
                   
                   FGSAAEDSYLNVWD YEKVGKNVGKKTPPGLFFQHAGHRD 
               
               
                   
                   
                 KVVDFHWNSFDPWTIVSVSDDGESTGGGGTLQIWRMSDL 
               
               
                   
                   
                 IYRPEDEVLAELERFEAHILSCQNK 
               
               
                   
               
               
                 190 
                 The amino acid sequence of SEQ ID 
                 MSS LSRELVFLILQFLDEEKFKESVHKLEQESG     NMK   
               
               
                   
                 459. The conserved G-protein beta 
                 
                   YFDEKAQAGEWDEVERYLSGFTKVDDNRYSMKIFFEIRK 
                 
               
               
                   
                 WD-40 repeat domains are 
                   QKYLEALDRQDRAK AVDILVKDLKVFSTFNEELYKEITQ 
               
               
                   
                 underlined. The Lissencephaly 
                 LLTLDNFRENEQLSKYGDTKSARTIMMSELKKLIEANPL 
               
               
                   
                 type-1-like homology motif is in 
                 FREKLIYPNLKASRLRTLINQSLNWQHQLCKNPRPNPDI 
               
               
                   
                 bold and the CTLH, C-terminal to 
                 KTLFTDHACGPPNGARTPTQPTASLGVLPKATTFTPIGP 
               
               
                   
                 LisH motif is in italics. 
                 HGPFPSSSTATSGLASWMSNPNMVTSPQAPVAVGPSVPV 
               
               
                   
                   
                 PPNQATLLKRPRTPPGSSSVVDYQTADSEQLIKRLRPVS 
               
               
                   
                   
                 QSIDEATYPGPTLRVPWSTDDLP KTLARALNEPYPVTSI   
               
               
                   
                   
                   DFHPSQQTFLLVGTKNGEITLWE VGSREKLATRSFKIWD 
               
               
                   
                   
                 NANCSNHLEAAFVKDSSVSINRVLWSPDGTLIGIAFTKH 
               
               
                   
                   
                 LVHTYTFQGLD LRQHLEIDAHVGGVNDLAFSHPNKQLCV   
               
               
                   
                   
                   VTCGDDKMIKVWD AVT GRKLYNFEGHDAPVYSVCPHHKE   
               
               
                   
                   
                   NIQFIFSTAVDGKIKAWL YDHLGSRVDYDAPGHSCTTMM 
               
               
                   
                   
                 YSADGTRLFSCGTSKEGESFLVEWNESEGAIKRTYSGLR 
               
               
                   
                   
                 KKGSGVVQFDTTQNHFLAVGDEHLIKFWDMDSTNMLTSC 
               
               
                   
                   
                 DAEGGLLNLPRLRFNKEGSLLAVTTVNGIKILANADGQK 
               
               
                   
                   
                 LLKTMENRTFDLPSRAHIDAASATSSPATGRMERIERTS 
               
               
                   
                   
                 SANTVSGINGVDPAQSSEKLRLSDDLSEKTKIWKLTEIT 
               
               
                   
                   
                 DSIQCRCITLPENAAEPASKVSRLLYTNSGVGLLALGSN 
               
               
                   
                   
                 AVHKLWKWNRSEQNPSGKATASVHPQRWQPTSGLL MTND   
               
               
                   
                   
                   ITDINPEEAVPCIALSKNDSYVMSASGGKVSLFN MMT FK   
               
               
                   
                   
                   VMTTFMPPPPASTFLAFHPQDNNIIAIGMEDSTIHIYN V 
               
               
                   
                   
                 RV DEVKTKLKGHQKRITGLAFSSTQNILVSSGADAQLCV   
               
               
                   
                   
                   WN TETWEKRKSKTIQMPVGKTVSGDTRVQFHSDQLHILV 
               
               
                   
                   
                 VHETQLAIYDAYKLERQYQWVPQDALSAPILYATYSCNR 
               
               
                   
                   
                 QLIYATFSDG 
               
               
                   
               
               
                 191 
                 The amino acid sequence of SEQ ID 
                 MAKDEEEFRGEMEERLVNEEYKIWKKNTPFLYDLVITHA 
               
               
                   
                 460. The conserved G-protein beta 
                 LEWPSLTVQWLPDREEPPGKDYSVQKMILGTHTSDNEPN 
               
               
                   
                 WD-40 repeat domains are 
                 YLMLAQVQLPLEDAENDARQYDDERGEIGGFGCANGKVQ 
               
               
                   
                 underlined. 
                 VIQQINHDGEVNRARYMPQNPFIIATKTVSAEVYVFDYS 
               
               
                   
                   
                 KHPSKPPQDGGCH PDLRLRGHNTEGYGLSWSPFKHGHLL   
               
               
                   
                   
                   SGSDDAQICLWD INVPAKNKVLE AQQIFKVHEGVVEDVA   
               
               
                   
                   
                   WHLRHEYLFGSVGDDRHLLIWD LRTSATNK PLHSVVAHQ   
               
               
                   
                   
                   GEVNCLAFNPFNEWVLATGSADRTVKLFD LRKISS ALHT   
               
               
                   
                   
                   FSCHKEEVFQIGWSPKNETILASCSADRRLMVWD LSRID 
               
               
                   
                   
                 EFQTPEDALDGPPE LLFIHGGHTSKISDFSWNPCEDWVI   
               
               
                   
                   
                 ASVAEDNILQIWQMAENIYHDEEDDMPPEEVV 
               
               
                   
               
               
                 192 
                 The amino acid sequence of SEQ ID 
                 MSPGV KQTGSQKFESGHQDVVHDVTMDYYGKRIATCSAD   
               
               
                   
                 461. The conserved G-protein beta 
                   RTIKLFG LNASD TPSLLASLTGHEGPVWQVAWAHPKFGS   
               
               
                   
                 WD-40 repeat domains are 
                   MLASCSYDGRVIIWR EGQQEN EWSQVQVFKEHEASVNSI   
               
               
                   
                 underlined. 
                   SWAPHELGLCLACGSSDGSITVFT CREDG SWDKTKIDQA   
               
               
                   
                   
                 
                   HQVGVTAVSWAPASAPGSLVGQPSDPIQKLVSGGCDNTA 
                 
               
               
                   
                   
                   KVWK FYNGSW KLDCFPPLQMHTDWVRDVAWAPNLGLPKS   
               
               
                   
                   
                   TIASCSQDGKVVIWT QGKEG DKWEGRILNDFKIPVWRVN   
               
               
                   
                   
                   WSLTGNILAVADGNNSVTLWK EAVDGDWNQVTTVQ 
               
               
                   
               
               
                 193 
                 The amino acid sequence of SEQ ID 
                 MSSGVK QTGSQKFESGHQDVVHDVTMDYYGKRIATCSAD   
               
               
                   
                 462. The conserved G-protein beta 
                   RTIKLFG MNTSDT PTLLASLTGHEGPVWQVAWAHPKFGS   
               
               
                   
                 WD-40 repeat domains are 
                   MLASCSYDRRVIIWR EGQQENE WSQVQVFKEHEASVNSI   
               
               
                   
                 underlined. 
                   SWAPHELGLCLACGSSDGSITVFT GREDGS WDKTKIDQA   
               
               
                   
                   
                 
                   HQVGVTAVSWAPASAPGSLVGQPSDPVQKLVSGGCDNTA 
                 
               
               
                   
                   
                   KVWK FYNGSWK LDCFPPLQMHTDWVRDVAWAPNLGLPKS   
               
               
                   
                   
                   TIASCSQDGRVVIWT QGKEGD KWEGKILNDFKTPVWRIS   
               
               
                   
                   
                   WSLTGNILAVADGNNNVTLWK EAVDGEWNQVTTVQ 
               
               
                   
               
               
                 194 
                 The amino acid sequence of SEQ ID 
                 MKKRSRPSNGHLSTAAKNKSRKTAPITKDPFFDSAHNRN 
               
               
                   
                 463. The conserved G-protein beta 
                 KSKGKGKSRGKGEEIFSSDEDDDAIGRDAPAEEEEEIAE 
               
               
                   
                 WD-40 repeat domains are 
                 EERETADEKRLRVAKAYLDKIRAITKANEEDNEEEAGED 
               
               
                   
                 underlined. 
                 EETEAERRGKRDSLVAEILQQEQLEESGRVQRQLASRVV 
               
               
                   
                   
                 TPSKLVECRVVKRHKQSVTAVALTEDDLRGFSASKDGTI 
               
               
                   
                   
                 IHWDVETGASEKYEWPSQAVSVSSSNEVSKT QKSKGSKK   
               
               
                   
                   
                   QGSKHVLSMAVSSDGRYLATGGLDRYIHLWD TRT QKHIQ   
               
               
                   
                   
                   AFRGHRGAVSCLAFRQGTQQLISGSFDRTIKLWS AEDRA 
               
               
                   
                   
                 YMDTLYGHQSEILAVDCLRKERVLSVGRDHTLRLWKVP E   
               
               
                   
                   
                   ETQLVFRGHAASLECCCFINNEDFLSGSDDGSIELWS ML 
               
               
                   
                   
                 RKKPVFMAKNAHGHAIVENLSEDTSTREEPDEEVTTRQL 
               
               
                   
                   
                 PNGNSIGNGMTNQMGITPSVESWVGAVTVCRGTDLAASG 
               
               
                   
                   
                 AGNGVVRLWAIENSSKSLRALHDIPLTGFVNSLTFARSG 
               
               
                   
                   
                 RFLIAGVGQEPRLGRWGRIQAARNGVTLCPIELS 
               
               
                   
               
               
                 195 
                 The amino acid sequence of SEQ ID 
                 MAATFGTINTATSPHN PNKSFEIVQPPNDSISSLSFSPK   
               
               
                   
                 464. The conserved G-protein beta 
                   ANYLVATSWDNQVRCWE VLQTG ASMPKAAMSHDQPVLCS   
               
               
                   
                 WD-40 repeat domains are 
                   TWKDDGTAVFSAGCDKQAKMWP LLT GGQPVTVAMHDAPI   
               
               
                   
                 underlined. 
                   KDIAWIPEMNLLATGSWDKTLKYWD TR QSNPVHTQQLPE   
               
               
                   
                   
                   RCFALSVRHPLMVVGTADRNLIIFN LQN PQTEFKRISSP   
               
               
                   
                   
                   LKYQTRCVAAFPDKQGFLVGSIEGRVGVHH VEEA QQSKN   
               
               
                   
                   
                 
                   FTFKCHRDSNDIYAVNSLNFHPVHQTFATAGSDGAFNFW 
                 
               
               
                   
                   
                   D KDSKQRLKAMARSNQPIPCSTFNSDGSLYAYAVSYDWS 
               
               
                   
                   
                 KGAENHNPATAKHHILLHVPQESEIKGKPRVTTSGRK 
               
               
                   
               
               
                 196 
                 The amino acid sequence of SEQ ID 
                 MVVMDKGTHQTNEDESESEFIDEDDVIDEISIDEEDLPD 
               
               
                   
                 465. The conserved G-protein beta 
                 ADVEGEDVQEDNKRSEPDENSSSLDDAIHTFEGHEDTLF 
               
               
                   
                 WD-40 repeat domains are 
                 AVACSPVDATWVASGGGDDKAFMWRIGH ATPFFELKGHT   
               
               
                   
                 underlined. 
                   DSVVALSFSNDGLLLASGGLDGVVRIWD AST GNLIHVLD   
               
               
                   
                   
                   GPGGGIEWVRWHPKGHLVLAGSEDYSTWMWN ADL GKCLS   
               
               
                   
                   
                   VYTGHCESVTCGDFTPDGKAICTGSADGSLRVWN PQTQE 
               
               
                   
                   
                 S KLTVKGYPYHTEGLTCLSISSDSTLVVSGSTDGSVHVV   
               
               
                   
                   
                   N IKN GKVVASLVGHSGSIECVRFSPSLTWVATGGMDKKL   
               
               
                   
                   
                   MIWE LQ SSSLRCTCQHEEGVMRLSWSLSSQHIITSSLDG   
               
               
                   
                   
                   IVRLWD SRS GVCERVFEGHNDSIQDMVVTVDQRFILTGS   
               
               
                   
                   
                   DDTTAKVFE IGAF 
               
               
                   
               
               
                 197 
                 The amino acid sequence of SEQ ID 
                 MPVFRTAFNGYAVKFSPFVETRLAVATAQNFGIIGNG RQ   
               
               
                   
                 466. The conserved G-protein beta 
                 
                   HVLELTPNGIVEVCAFDSSDGLYDCTWSEANENL VVSAS   
                 
               
               
                   
                 WD-40 repeat domains are 
                     GDGSVKIWD     I ALPPV ANPIRSLEEHAREVYSVDWNLVRK   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                   DCFLSASWDDTIRLWT IDR PQSMRLFKEHTYCIYAAVWN   
               
               
                   
                 repeats signature is in bold. 
                   PRHADVFASASGDCTVRIWD VRE PNATIIIPAHEHEILS   
               
               
                   
                   
                   CDWNKYNDCMLVTGSVDKLIKVWD IRTY RTPMTVLEGHT   
               
               
                   
                   
                   YAIRRVKFSPHQESLIASCSYDMTTCMWD YRAPE DALLA   
               
               
                   
                   
                   RYDHHTEFAVGIDISVLVEGLLASTGWDETVYVWQ HGMD 
               
               
                   
                   
                 PRAC 
               
               
                   
               
               
                 198 
                 The amino acid sequence of SEQ ID 
                 MDSRNRRSRLNLPPGMSPSSLHLETTAGSPGLSRVNSSP 
               
               
                   
                 467. The conserved G-protein beta 
                 STPSPSRTTTYSDRFIPSRTGSRLNGFALIDKQPQPLPS 
               
               
                   
                 WD-40 repeat domains are 
                 PTRSAAEGRDDASSSSASAYSTLLRNELFGEDVVGPATP 
               
               
                   
                 underlined. 
                 ATPEKSTGLYGGSRDSIKSPMSPSRNLFRFKNDHGGNSP 
               
               
                   
                   
                 GSPYSASTVGSEGLFSSNVGTPPKPARKITRSPYKVLDA 
               
               
                   
                   
                 PALQDDFYLNLVDWSSNNVLAVGLGTCVYLWSACTSKVT 
               
               
                   
                   
                 KLCDLGVNDSVCSVGWTPQGTHLAVGTNIGEVQIWDTSR 
               
               
                   
                   
                 CKKVRTMGGHCTRAGALAWSSYILSSGSRDRNILHRDIR 
               
               
                   
                   
                 VQ DDFIRKLVGHKSEVCGLKWSYDDRELASGGNDNQLLV   
               
               
                   
                   
                   WN QQSAQPLLRFNEHTAAVKAIAWSPHQHGILASGGGTA 
               
               
                   
                   
                 DRCLRFWNTATDTRLNCVDTGSQVCNLVWCKNVNELVST 
               
               
                   
                   
                 HGYSQNQIMVWRYPS MSKLATLTGHTLRVLYLAISPDGQ   
               
               
                   
                   
                   TIVTGAGDETLRFWS IFPSPKSQSAVHDSGLWSLGRTHIR 
               
               
                   
               
               
                 199 
                 The amino acid Sequence of SEQ ID 
                 MEKK KVVVPIVCHGHSRPIVDLFYSPVTPDGLFLISASK   
               
               
                   
                 468. The Conserved G-protein beta 
                   DSSTMLRN GE TGDWIGTFEGHKGAVWSCCLDNRALRAAS   
               
               
                   
                 WD-40 repeat domains are 
                   GSADFSAKIWD AL TGDELHCFVHKHIVRACAFSESTSLL   
               
               
                   
                 underlined. 
                   LTGGHEKILRIFD LNR PDAPPKEVDNSPGSIRTVAWLHS   
               
               
                   
                   
                   DQTILSSNSDAGGVRLWD LR TEKIVRVLETKSPVTSAEV   
               
               
                   
                   
                   SQDGRYITTADGNSVKFWD AN HFGMVKSYTMPCMVESAS   
               
               
                   
                   
                   LEPTMGNMFVAGGEDMWVRLFD FH TGEEIACNKGHHGPV   
               
               
                   
                   
                   HCVRFAPGGESYSSGSEDGTIRIWQ TLNMNSEENESYGV 
               
               
                   
                   
                 NGLSGKVRVGVDDVVQKVEGFQITADGHLNDKPEKPNP 
               
               
                   
               
               
                 200 
                 The amino acid Sequence of SEQ ID 
                 MERYSQGTQKKSEIYTYEAPWQIYGMNWSVRKDKKFRLG 
               
               
                   
                 469. The Conserved G-protein beta 
                 IGSFLEEYNNRVEIIELDEESGEFKSDPRLAFDHPYPTT 
               
               
                   
                 WD-40 repeat domains are 
                 KIMFVPDKECQRPDLLATTGDYLRIWQVCEDRVE PKSLL   
               
               
                   
                 underlined. 
                   NNNKNSEFCAPLTSFDWNDADPKRIGTSSIDTTCTIWD I 
               
               
                   
                   
                 E KEVVDTQLIAHDKEVYDIAWGEVGVFASVSADGSVRVF   
               
               
                   
                   
                   D LRDKEHSTIIYESSQPETPLLRLGWNKQDPRFIATILM 
               
               
                   
                   
                 DSCKVVILDIRF PTLPVAELQRHQASVNTIAWAPHSPCH   
               
               
                   
                   
                   ICTAGDDSQALIWE LSSVSQPLVEGGGLDPILAYTAAAE 
               
               
                   
                   
                 INQLQWSSMQPDWVAIAFSNEVQILRV 
               
               
                   
               
               
                 201 
                 The amino acid sequence of SEQ ID 
                 MQSENNLDESL HLREVQELQGHTDTVWAVAWNPVTGIDG   
               
               
                   
                 470. The conserved G-protein beta 
                   APSMLASCSGDKTVRIWE NTHTLNSTSP SWACKAVLEET   
               
               
                   
                 WD-40 repeat domains are 
                   HTRTVRSCAWSPNGKLLATASFDATTAIWE NVGG EFECI   
               
               
                   
                 underlined. 
                   ASLEGHENEVKSVSWSASGMLLATCGRDKSVWIWD VQPG 
               
               
                   
                   
                 NE FECVSVLQGHTQDVKMVQWHPNRDILVSASYDNSIKV   
               
               
                   
                   
                   WA EDGDGD DWACMQTLGNSVSGHTSTVWAVSFNSSGDRM   
               
               
                   
                   
                   VSCSDDLTLMVWD TSINPAERSGNAG PWKHLCTISGYHD   
               
               
                   
                   
                 
                   RTIFSVHWSRSGLIASGASDDCIRLFS 
                 
               
               
                   
               
               
                 202 
                 The amino acid sequence of SEQ ID 
                 MK RAYKLQEFVAHASNVNCLKIGKKSSRVLVTGGEDHKV   
               
               
                   
                 471. The conserved G-protein beta 
                   NMWA IGK PNAILSLSGHSSAVESVTFDSAEALVVAGAAS   
               
               
                   
                 WD-40 repeat domains are 
                   GTIKLWD LE EAKIVRTLTGHRSNCISVDFHPFGEFFASG   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                   SLDTNLKIWD IR RKGCIHTYKGHTRGVNSIRFSPDGRWV   
               
               
                   
                 repeats signature is in bold. 
                   VSGGEDNIVKLWD LT AGKLMHDFKCHEGQIQCMDFHPQE   
               
               
                   
                   
                   FL LATGSADRTVKFWD     L E TFELIGSAGPETTGVRAMIFN   
               
               
                   
                   
                   PDGRTLLTGLHESLKVFS WEPLRCYDAVDVGWSKLADLN 
               
               
                   
                   
                 IHEGKLLGCSYNQSCVGVWVVDISRVGPYAAGNVSRTNG 
               
               
                   
                   
                 HNEAKLASSGHPSVQQLDNNLKTNMARLSLSHSTESGIK 
               
               
                   
                   
                 EPKTTTSLTTTEGLSSTPQRAGIAFSSKNLPASSGPPSY 
               
               
                   
                   
                 VSTPKKNSTSRVQPTTNFQTLSRPDIVPVIVPRSNSLRP 
               
               
                   
                   
                 ETTSDVKKEMNNFGRVVPSTVSTKSTDVIKSGSNRDESD 
               
               
                   
                   
                 KIDSINQKRMTGNDKTDLNIARAEQHVSSRLDNTNTSSV 
               
               
                   
                   
                 VCDGNQPAARWIGAAKFRRNSPVDPVVSPHDRSPTFPWS 
               
               
                   
                   
                 ATDDGVTCQPDRQVTAPELSKRVVEPGRARALVASWETR 
               
               
                   
                   
                 EKALTADTPVLVSGRPPTSPGVDMNSFIPRGSHGTSESD 
               
               
                   
                   
                 LTVSDDNSAIEELMQQHNAFTSILQARLTKLQVIRRFWQ 
               
               
                   
                   
                 RNDLKGAIDATGKMGDHSVSADVISVLIERSEIFTLDIC 
               
               
                   
                   
                 TVILPLLTRLLQSETDRHLTVAMETLLVLVKTFGDVIRA 
               
               
                   
                   
                 TISATPTIGVDLQAEQRLERCNLCYVELENIKQILVPLI 
               
               
                   
                   
                 RRGGAVAKSAQELSLALQEV 
               
               
                   
               
               
                 203 
                 The amino acid sequence of SEQ ID 
                 MSTLEIEARDVIKIVLQFCKENSLHQTFQTLQNECQVSL 
               
               
                   
                 472. The conserved G-protein beta 
                 NTVDSLETFVADINSGRWDVILPQVAQLKLPRKKLEDLY 
               
               
                   
                 WD-40 repeat domains are 
                 EQIVLEMIELRELDTARAILRQTQAMGFMKQEQPERYLR 
               
               
                   
                 underlined and the Trp-Asp (WD) 
                 LEHLLVRTYFDPREAYHESSKEKRRSQIAQALASEVTVV 
               
               
                   
                 repeats signature is in bold. 
                 PPSRLMALIGQSLKWQQHQGLLPPGTQFDLFRGTAAVKA 
               
               
                   
                   
                 DEEEMY PTTLAHTIKFGKQSHPECARFSPDGQYLVSCSV   
               
               
                   
                   
                   DGFIEVWD YISGKLKKDL QYQADDSFMMHDDAVLCVDFS   
               
               
                   
                   
                   RDSEMLASGSQDGKIKVWR IR TGQCLRRLERAHSQGVTS   
               
               
                   
                   
                   LSFSRDGSQLLSTSFDSTARIHG LK SGKALKEFRGHTSY   
               
               
                   
                   
                   VNDAIFTSDGGR VITASSDCTVKVWD     V K TTDCIQTFKPP   
               
               
                   
                   
                   PPLKGGDVSVNSVHLFPKNSEHIVVCNKASSIYIMT L QG   
               
               
                   
                   
                 
                   QVVKSFSSGKREGGDFVAACISPKGEWIYCVGEDRNIYC 
                 
               
               
                   
                   
                   FS QQ SGKLEHLMKAHDKDIIGVTPHPHRNLLVTYSEDST   
               
               
                   
                   
                   MKIWK P 
               
               
                   
               
               
                 204 
                 The amino acid sequence of SEQ ID 
                 MDIELEDQPFDLDFHPSAPIVAVALITGRLQLFRYVDIS 
               
               
                   
                 473. The conserved G-protein beta 
                 S EPERLWTVTAHTESCRAARFINAGSSVLTASPDCSILA   
               
               
                   
                 WD-40 repeat domains are 
                   TN VE TGQPVARLDNAHGAAINCLTNLTESTIASGDENGI   
               
               
                   
                 underlined. 
                   IKVWD TR QNSCCNKFKAHEDYISDMEFVPDTMQLLGTSG   
               
               
                   
                   
                   DGTLSVCN LR KNKVHARSEFSEDELLSVALMKNGKKVVC   
               
               
                   
                   
                   GSQEGVLLLYS WGY FKDCSDRFVGHPHSVDALLKLDEDT   
               
               
                   
                   
                   VLTGSSDGIIRVVS IL PNKMIGVIGEHSSYPIERLAFSH   
               
               
                   
                   
                   DRNVLGSASHDQILKLWD IHYLHEDDEPETNKQEAVNDE 
               
               
                   
                   
                 NVDMDLDVDTEKRPRGSKRKKRAEKGQTSSQKQSSDFFA 
               
               
                   
                   
                 DI 
               
               
                   
               
               
                 205 
                 The amino acid sequence of SEQ ID 
                 MDRIQQIPHTCVARKINLPLGMSKESLALNLPANLAPTM 
               
               
                   
                 474. The conserved G-protein beta 
                 SPPSITYSDRFIPSRKASNFEEFALPDKTSPSPNSAGGQ 
               
               
                   
                 WD-40 repeat domains are 
                 SSSTNGEGRDDACAAYSALLRTELFPATPDKTEGCRRPV 
               
               
                   
                 underlined. 
                 IGSPSGNVFRFKSQQCKSQSPFSLCPVGEDGDLSETGAV 
               
               
                   
                   
                 ARKTTRKIPRSPFKVLDAPALQDDFYLNLVDWSSHNILA 
               
               
                   
                   
                 VGLSACVYLWSASSSKVTKLCDLGLDDNVCSVAWTQRGT 
               
               
                   
                   
                 YLAVGTNNGGVQIWDAAHCKQVRTMEGHCTRVGTLAWNS 
               
               
                   
                   
                 HILSSGGRDRNILQRDIRAQ DDFVSKFSGHKSEVCGLKW   
               
               
                   
                   
                   SYDNRELASGGNDNQLFVWN QQSQQPVLKYNEHTAAVKA 
               
               
                   
                   
                 IAWSPHQHGLLASGGGTADRCIRFWNTATNTSLNCVDTG 
               
               
                   
                   
                 SQVCNLVWSKNVNELVSTHGYSQNQIIVWRYPT MSKLAT   
               
               
                   
                   
                   LTGHTLRVLYLAISPDGQTIVTGAGDETLRFWN VFPSSK 
               
               
                   
                   
                 TQQNTIRDMGVWSSGRTHIR 
               
               
                   
               
               
                 206 
                 The amino acid sequence of SEQ ID 
                 MAGGQGEGEEKVDKLSMELTEDVMK SMEIGAVFKDYNGK   
               
               
                   
                 475. The conserved G-protein beta 
                   INSLDFHRTNNYLVTASDDEAIRLFD TASATWQKTSYSK 
               
               
                   
                 WD-40 repeat domains are 
                 KYGVDLICFTNHQTSVLYSSKNGWDESLRHLSLM DNKYL   
               
               
                   
                 underlined. 
                   RYFKGHHDRVVSLCMSPKGECFMSGSLDRTVLLWD LRID 
               
               
                   
                   
                 KCQGLIRVRGRPAVAYDEQGLVFAISNEGGLIKMFDARL 
               
               
                   
                   
                 YDK GPFDTFVVEGDKSEASGIKFSNDGKLILLSTMDSNI   
               
               
                   
                   
                   HVLD AY QGTTVHSFSVEAVPNGGEAVPNGGTLEASFSPD   
               
               
                   
                   
                   GKFVISGSGNGNIHAWS VNSGKEVACWTTEGVIPAVVKW 
               
               
                   
                   
                 APRRLMFASGSSVLSLWVPDLSKLASLTGSNSNSAY 
               
               
                   
               
               
                 207 
                 The amino acid sequence of SEQ ID 
                 MHRVGSTGNTSNSSRPRR EKRLTYVLNDANDSRHCSGIN   
               
               
                   
                 476. The conserved G-protein beta 
                   CLVISKLSLLGGNDYLFSGSRDGTLKRWE LADD SAVCSA   
               
               
                   
                 WD-40 repeat domains are 
                   TFESHVDWVNDAVLTGETLVSCSSDTTLKTWR PFS DGVC   
               
               
                   
                 underlined. 
                   TRTLRQHSDYVTCLAAASKNSNIVASGGLGREVFIWD IE 
               
               
                   
                   
                 AAMAPVSRTSEAMDDDTSNGVLSSGNSVLSTTVRSTNAT 
               
               
                   
                   
                 NSASLHTSQL QGYTPIAAKGHKESVYALAMNDVGTLLVS   
               
               
                   
                   
                   GGTEKVVRVWD PR SGAKQMKLRGHTDNVRALILDSTGRF   
               
               
                   
                   
                   CLSGSSDSIIRLWD LG QQRCVHSYAVHTDSVWALASTPN   
               
               
                   
                   
                   FSHVYSGGRDLSLYLTD LTTRESLLLCMEKHPLLRLTLQ 
               
               
                   
                   
                 DDSIWVATTDSSLHRWPAEGQNPPKMFQRGGSFLAGNLS 
               
               
                   
                   
                 FTRARACLEGSAPVPVNTQPSFVIPGSPGIVQHEILNNR 
               
               
                   
                   
                 RHVLTKDAEGTVKLWEITRGAVLDDYGKVSFEEKKEELF 
               
               
                   
                   
                 EMVSIPAWFTMDTRLGSMSVHLDTPQCFTAEMYAVDLNV 
               
               
                   
                   
                 PDAPEEQKINLAQETLRGLLAHWLSRRRQRLATQASANG 
               
               
                   
                   
                 DFPAGQENALRNHISSRIDVHDDAETHIAGILPAFDFST 
               
               
                   
                   
                 TSPPSIITEGSQGGPWRKKITDLDGTEDEKDFPWWCLEC 
               
               
                   
                   
                 VLHGRLSPRESLKCSFYLHPYEGTTVQVLTQGKLSAPRI 
               
               
                   
                   
                 LRIQKVINYVLEKMVLDRPLDSSNSETTFTPGLSGNQSH 
               
               
                   
                   
                 AAVVGDGSLRSGARVWQQKAKPLVEILCNNQVLSPDMSL 
               
               
                   
                   
                 ATVRTYIWKKPDDLYLYYRLVQNR 
               
               
                   
               
               
                 208 
                 The amino acid sequence of SEQ ID 
                 MM KGKTIQMQAAHQNHDGETSVACVLWDWHAKHLITAGA   
               
               
                   
                 477. The conserved G-protein beta 
                   DNTILIHS YPSSS SSKPITLRHHKNAVTALAINSNVRSL   
               
               
                   
                 WD-40 repeat domains are 
                   ASGSVDHSVKLYS YP GGEFQSNVTRFTLPIRSLAFNKSG   
               
               
                   
                 underlined. 
                   ELLAAAGDDEGIKLIS TI DNSIARVLKGHNGPVTSISFD   
               
               
                   
                   
                   PKNEFLASSDSDGTVIYWE LS TGKPVHTLKKIAPNTTSN   
               
               
                   
                   
                   PTSLNQISWRPDGEMLAVPGRKSEVSMYD RDTAEKLFSL 
               
               
                   
                   
                 KGGHSDTICSLAWSPNGKYIATAGTDRQVMVWDADRRQD 
               
               
                   
                   
                 IDKQRFDNPICSVAWKPSDNALAVIDVLGRFGVWESPIA 
               
               
                   
                   
                 SHMKSPADGAERYDNMEDEEPLMARYEEELEDSVSGSLN 
               
               
                   
                   
                 EIINDDDDDDEMGKIPRKILQKKPSVKVEKGKEESNAKA 
               
               
                   
                   
                 FKSGQDSFKLKSAMQEAFQPGATQRQSGKRNFLAYNMLG 
               
               
                   
                   
                 SVITFDNDGFSHIEVDFHDIGKGCRVPSMTDYFGFTMAS 
               
               
                   
                   
                 LSESGSVFGSPQKGEKNPSTLMYRPFSSWANNSEWSMRF 
               
               
                   
                   
                 PMGEEVKAVALGSGWVAAVTSLNFLRVFSEGGLQKFVLS 
               
               
                   
                   
                 MDGPVVTAAGYENLLVVVSHASNPLLSGDQVLSFTVYDI 
               
               
                   
                   
                 SQKTCPLSGRLPLSPGSHLTWLGFSEEGLLSSYDSEGNL 
               
               
                   
                   
                 RVFTNDYNGCWVPIFSAARERKSETESIWMVGLNSTQVF 
               
               
                   
                   
                 CVVCKLPDTYPQVAPKPVLSVLNLSLPLACSDLGADDLE 
               
               
                   
                   
                 NEYLRGSLLLSQMQKKAEDAVACGRESNMEEDSIFKMEA 
               
               
                   
                   
                 ALDRCLLRLIANCCKGDKLVRATELARLLSLEKSLQGAI 
               
               
                   
                   
                 KLVSAMKLPMLAERFNTILEEKILQENMETISCRRLTSE 
               
               
                   
                   
                 AQDMDTPISISVKQVSYGANLGDSPFLPNRQVEPKHSTP 
               
               
                   
                   
                 VFSKPDTKIEVDTSEAIAKGCDAQNGNIKSGDAEVQPAS 
               
               
                   
                   
                 HNDSIQKPSNPFAKASNTSANQAVQRNASLLSSIKQMKT 
               
               
                   
                   
                 ATENEGKRKERARSGSLPQKPAKQSKIS 
               
               
                   
               
               
                 209 
                 The amino acid Sequence of SEQ ID 
                 MKQKRKGHQVDDPKYSVQTPQEDDTPNESGPASEEVESS 
               
               
                   
                 478. The conserved G-protein beta 
                 DEEGGNSSNIEDDIIYSSSEEDPVVSSDYEEDEDAESDA 
               
               
                   
                 WD-40 repeat domains are 
                 EGVTAEQELEGDIDNALQNYMGTLTVLSNFHGENLKNAE 
               
               
                   
                 underlined. 
                 GEDTSGDDDDEEEMPKRAEESDSPEDENDERPKRAEESD 
               
               
                   
                   
                 FSEDEDEERPKRAEESDSSEDEVPSRNTVGDVPLRWYKD 
               
               
                   
                   
                 EQHIGYDIKGKKIKKQPKKDQLDSFLASTDDSSDWRKVY 
               
               
                   
                   
                 DEYNDEEVELTKDEIKFISRLRKGTIPHADVNPYEPYVD 
               
               
                   
                   
                 WFDWKDKGHPLSNAPEPKRRFIPSKWEAKKVVKLVRAIR 
               
               
                   
                   
                 KGWITFQKAEEKPRFYLMWGDDLKPSEKMANGLSYIPAP 
               
               
                   
                   
                 KPKLPGHEESYNPPPEYIPTQEEINSYQLMYEEDRPKFI 
               
               
                   
                   
                 PKRFDSLRNVPAYDRFLSEIFERCLDLYLCPRTRKKRIN 
               
               
                   
                   
                 IDPESLIPKLPKPKDLQPF PSICFLEYKGHTGAVSCISP   
               
               
                   
                   
                   ESSGQWLASGSKDGTVRIWE VETARCLKVWDIGRPIQHI 
               
               
                   
                   
                 AWNPVSQLSILAVAVDEEVLVLNTGLGSEDSQEKVAELL 
               
               
                   
                   
                 HVKSKPVSADDLGDNTSLTKWIKHEKFDGIKLTHLKPVH 
               
               
                   
                   
                 LISWHHKGDYFATVAPDGNTRAVLVHQLSKQQTQNPFKK 
               
               
                   
                   
                 MQGRVVHVLFHPSRAIFFVATKTHVRVYDLVKQQLVKRL 
               
               
                   
                   
                 VTGLHEVSSMAVHHKGDNLLVGSKEGKVCWFDMDL STQP   
               
               
                   
                   
                   YKTLKNHSKDIHSVAFHDSYPLFASCSDDCKAYVFY GLV 
               
               
                   
                   
                 YSDLLQNPLIVPLKVLQGHQSVNGMGVLDCQFHPKQPWL 
               
               
                   
                   
                 FTAGADSVVKLYCN 
               
               
                   
               
               
                 210 
                 The amino acid sequence of SEQ ID 
                 MMSLKRGFEESLVPAKRQKTELSTVTYGDGPRRTSSL ES   
               
               
                   
                 479. The conserved G-protein beta 
                   PIMLLTGHHAAIYTMKFNPTGTVIASGSHEREIFLWN VH 
               
               
                   
                 WD-40 repeat domains are 
                 GD CKNFMVLKGHKNAVLDLHWTTDGCQIISASPDKTLRA   
               
               
                   
                 underlined. 
                   WD VET GKQIKKMAEHSSFVNSCCPSRRGPPLVVSGSDDG   
               
               
                   
                   
                   TAKLWD LRH RGAIQTFPDKYQITAVGFSDAADKIYSGGI   
               
               
                   
                   
                   DNEIKVWD LRR GEVTMRLQGHTDTITGMQLSSDGSYLLT   
               
               
                   
                   
                   NSMDCSLRIWD MRPYAPQNRCV KILTGHQHNFEKNLLKC   
               
               
                   
                   
                   SWSSDGSKVTAGSADRMVYIWD TTTRRILYKLPGHTGSV 
               
               
                   
                   
                 NETGFHPTQPIIGSCSSDKQIYLGEIEPNVGYQAVI 
               
               
                   
               
               
                 211 
                 The amino acid sequence of SEQ ID 
                 MEFSDTYKHTGPCCFSPDARYLAIAVDYRLVIRDVVTLK 
               
               
                   
                 480. The conserved G-protein beta 
                 VVQLYSCMDKISNIEWALDSEYILCGLYKRAMVQAWS LS   
               
               
                   
                 WD-40 repeat domains are 
                 
                   QPEWTCKIDEGPAGIAHARWSPDSRHIITTSDFQLRLTV 
                 
               
               
                   
                 underlined. 
                   WS LVNTACIHIQWPKHASKGVSETQDSKfAAIATRRDCK 
               
               
                   
                   
                 DYVNLLSCHTWEVMGTFTVDTIDLADLEWSPNDSAIVVW 
               
               
                   
                   
                 DSPLEYKVLIYSP DGRCLFKYQAYDSWLGVKTVAWSPCS   
               
               
                   
                   
                   QFLAVGSYDQTLRTLN HLTWKPFAEFVHVSTVRGPASAV 
               
               
                   
                   
                 VFKEVEEPWNLDVSGLHLNDDNAHDIQDGKPAEGHSRVR 
               
               
                   
                   
                 YKVVEFPVNVSSQKHPVDKPNPKQGIGLLAWSRDSQYLF 
               
               
                   
                   
                 TRNDNMPTALWIWDIC RLELAALLIQKEPIRAAAWDPVY   
               
               
                   
                   
                   PRVALCTGSSHLYMWT PSGACCVNIPLPQFVVSDLKWNP 
               
               
                   
                   
                 DGTSMLLKDRESFCCTFVPMLPEFNDDETNEE 
               
               
                   
               
               
                 212 
                 The amino acid sequence of SEQ ID 
                 MAKLIETHSCVPSTERGRGILIAGDAKTNSIIYCNGRSV 
               
               
                   
                 481. The conserved G-protein beta 
                 IMRNLD NPLEASVYGEHSYPATVARFSPNGEWVASGDTS   
               
               
                   
                 WD-40 repeat domains are 
                   GTVRIWG RGS DHTLKYEYKALAGRIDDLEWSADGQRIVV   
               
               
                   
                 underlined. 
                 
                   CGDSKGKSMVRAFMWDSGTNVGEFDGHSRRVLSCSFKPT 
                 
               
               
                   
                   
                   RPFRVATCGEDFLVNFYE GP PFRFKTSHRDHSNYVNCVR   
               
               
                   
                   
                   FAPDGSKFITVGSDRKGVIFD GK MGEKIGELSKEGGHTG   
               
               
                   
                   
                   SIYAASWSPDSKQVLTVSADKSAKIWE ISETGNGTVKKT 
               
               
                   
                   
                 LTFGSQGGADDMLVGCLWLNDYLITVSLGGIVSLLSAVD 
               
               
                   
                   
                 
                   PDKPPKTISGHMKSINAIALSLQSGQSEVCSSSYDGVIV 
                 
               
               
                   
                   
                   RWI LGVGYAGRVERKDSTQIKCLATIEGELVTCGFDNKV 
               
               
                   
                   
                 RRVPLLSEQHKESEPIDIGAQPKDLDVAVGCPELTFVST 
               
               
                   
                   
                 DAGIIIIR ASKIVSTTNVGYAVTAAAISPDGTEAVVGGQ   
               
               
                   
                   
                   DGKLRVYS IKGD TLLEESVLERHRGPINAIRFSPDGSMF   
               
               
                   
                   
                   ASGDLNREAVVWD RITR EVKLKNMVYHTARINCIAWSPD   
               
               
                   
                   
                   SSKVATGSLDTCILIYE VGK PASSRITIKGAHLGGVYGL   
               
               
                   
                   
                   AFSDQSTVISAGEDACVRVWS LP 
               
               
                   
               
               
                 213 
                 The amino acid sequence of SEQ ID 
                 MPQPSVILATAGYDHTVRFWEAT SGRCYRTLQYPDSQVN   
               
               
                   
                 482. The conserved G-protein beta 
                   HLEITPDKQYLAAAGNPHIRLFE VNSN NPQPVISYDSHT   
               
               
                   
                 WD-40 repeat domains are 
                   NNVTAVGFQCDGKWMYSGSEDGTVKIWD LR APGFQREYE   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                   SRAAVNTVVLHPNQTELISGDQNGNIRVWD LN ANSCSCE   
               
               
                   
                 repeats signature is in bold. 
                   LVPEDTAVRSLTVMWDGSLVVAANNHGTCYVWR LMRGTQ 
               
               
                   
                   
                 TMT NFEPLHKLQAHNSYILKCLLSPEFCEHHRY LATTSS     
               
               
                   
                   
                     DQTVKIWN     V D GFTLERTLTGHQRWVWDCVFSVDGAFLVT   
               
               
                   
                   
                   ASSDSTARLWD LSTGEAIRTYQGHHKATVCCALHDGTDG 
               
               
                   
                   
                 ASC 
               
               
                   
               
               
                 214 
                 The amino acid sequence of SEQ ID 
                 MLTKFETKSNRVKGLSFHPKRPWILASLHSGVIQLWDYR 
               
               
                   
                 483. The conserved G-protein beta 
                 M GTLIDKFDEHDGPVRGVHFHKTQPLFVSGGDDYKIKVW   
               
               
                   
                 WD-40 repeat domains are 
                   N YKM RQCLFTFVGHLDYIRTVHFHNEYPWIVSASDDQTI   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                   RLWN WQS RVCISVLTGHNHYVMSASFHPKEDL VVSASLD     
               
               
                   
                 repeats signature is in bold. The 
                     QTVRVWD     I SGLRKKTVSPADDLSRLAQMNTDLFGGGD VV   
               
               
                   
                 coatomer WD associated region is 
                   VKYVLEGHDRGVNWAAFHTSLPLIVSGADDRQVKLWR MN 
               
               
                   
                 in bold/italics. 
                 DTK AWEVDTLRGHTNNVSCVIFHARQDIIVSNSEDKSIR   
               
               
                   
                   
                   VWD MSKRTSVQTFRREHDRFWILAAHPEMNLLAAGHDSG 
               
               
                   
                   
                 MIVFKLERERPAYVVYGGSLLYVK   
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                 
                   
                   
                 
               
               
                   
                   
                    IPVLPPGKKSSLLMPPAPILHGGDWPLLRVTKGIFE 
               
               
                   
                   
                 GGLENSTSAAYEEEDEEAAADWGEDIDIENIEGENGEAT 
               
               
                   
                   
                 VLDDQEVKGGEDDEGGWDMEDLELPPDVAAANVGTNQKT 
               
               
                   
                   
                 LFVAPTLGMPVSQIWMQKSSLAGEHAAAGNFETALRLLT 
               
               
                   
                   
                 RQLGIKNFSPLKPLFLELYMGSHTFLPSFASVPAFSLAL 
               
               
                   
                   
                 QRGWSESASPNIRGPPALVYRLSVLEEKLTVAYRATTEG 
               
               
                   
                   
                 RFSEALRLFL 
               
               
                   
               
               
                 215 
                 The amino acid sequence of SEQ ID 
                 MDLLQNYQDDSEDSNPELRNHPPLEDATATSAPAGVENE 
               
               
                   
                 484. The conserved G-protein beta 
                 TSSSPDSSPLRLALPAKSCAPDVDETLMALGVPGSEKKN 
               
               
                   
                 WD-40 repeat domains are 
                 NHNKPIDPTQHSVTFNPSYDQLWAPLYGPAHPYAKDGIA 
               
               
                   
                 underlined. 
                 QGMRNHKLGFVEDSAIEPFMFDEQYNTFHRYGYAADPSA 
               
               
                   
                   
                 SLGSHIVGDLESLKKNDGASVYNLPKREHKRQKLEKKMI 
               
               
                   
                   
                 QKDENEEEEKEVGEEVDNPSTEEWLKKNRKSPWAGKKEG 
               
               
                   
                   
                 LQTELTEEQKKYAQEHAEKKGDREKGEKVEIVDKTTFHG 
               
               
                   
                   
                 KEERDYQGRSWIDPPKDAKATNDHCYIP KRWVHTWSGHT   
               
               
                   
                   
                   KGVSAIRFFPKYGHLLLSAGMDTKVKIWD VFNS GKCMRT   
               
               
                   
                   
                   YMGHSKAVRDISFSNDGSRFLSAGYDRNIKLWD TET GKV   
               
               
                   
                   
                   ISTFSTGKIPYVVKLHPDEDKQNVLLAGMSDKKIVQWD M 
               
               
                   
                   
                 NS GEITQEYDQHLGAVNTITFVDNNRRFVTSSDDKSLRV   
               
               
                   
                   
                   WE FGIP VVIKYISEPHMHSMPSISLHPNTNWLAAQSLDN   
               
               
                   
                   
                   QILIYS TRERFQ LNKKKRFAGHIAAGYACQVNFSPDGRF   
               
               
                   
                   
                   VMSGDGEGRCWFWD WKT CKVFRTLKCHDNVCIGCEWHPL   
               
               
                   
                   
                 
                   EQSKVATCGWDGMIKYWD 
                 
               
               
                   
               
               
                 216 
                 The amino acid sequence of SEQ ID 
                 MARKGLGTDPAIGSLMSSKKRKEYKVTNRFQEGKRPLYA 
               
               
                   
                 485. The conserved G-protein beta 
                 IAFNFIDARYHNIFATAGGTRVTIYQCLEGGAISVLQAY 
               
               
                   
                 WD-40 repeat domains are 
                 VDDD KDESFYTLSWACDVNGSPLLVAGGHNGIIRVLD VA 
               
               
                   
                 underlined and the Trp-Asp (WD) 
                 
                   NEKVHKSFVGHGDSVNEIRTQALKPSL ILSASKDESVRL   
                 
               
               
                   
                 repeats signature is in bold. 
                     WN     V Q TGICILIFAGAGGHRNEVLSVDFHPSDVYRIASCG   
               
               
                   
                   
                   MDNTVKIWS MKEFWTYVEKSFTWTDLPSKFPTKY VQFPV   
               
               
                   
                   
                   FIAAVHSNYVDCTRWLGNFILSKSVDNEVVLWE PYSKEQ 
               
               
                   
                   
                 STSDG VVDILQKYPVPECDIWFIKFSCDFHYNSMAVGNR   
               
               
                   
                   
                   EGKVYVWE LQSS PPNLIARLSHAHCKNPIRQTAISHDGS   
               
               
                   
                   
                   TILCCCDDGSMWRWD VVQ 
               
               
                   
               
               
                 217 
                 The amino acid sequence of SEQ ID 
                 MESGAGGSVGARVPSAKPEMLQQPPYSNGDDDNDMERGT 
               
               
                   
                 486. The conserved G-protein beta 
                 APVPSSNPNTVSKWELDKDFLCPICMQTMKDAFLTACGH 
               
               
                   
                 WD-40 repeat domains are 
                 SFCYMCIMTHLNNKSNCPCCSLYLTNNQLFPNFLLNKLL 
               
               
                   
                 underlined and the Trp-Asp (WD) 
                 KKTSACQMASTASPVENLCLSLQQGAEVSVKELDFLLTL 
               
               
                   
                 repeats signature is in bold. 
                 LAEKKRKMEQEEAETNMEILLDFLQRLRQQKQAELNEVQ 
               
               
                   
                   
                 ADLHYIKDDILALEKRRLELSRARERYSRKLHMLLDDPM 
               
               
                   
                   
                 DTTLGHAAIDDGNNVRTAFVRGGQGDAISGKFQQKKAEI 
               
               
                   
                   
                 KAQASSQGMQKRANFCHSDSQVLPTLSGLTIARKRRVLA 
               
               
                   
                   
                 QFDDLQECYLQKRRRWATQLRKQCDGGLRKERDGNSISR 
               
               
                   
                   
                 EGYHAGLEEFQSILTTFTRYS RLRVISELRHGDLFHSAN   
               
               
                   
                   
                   IVSSIEFDRDDELFATAGVSRRIKVFD FATVVNEPAD VH   
               
               
                   
                   
                   CPVVEMSTRSKLSCLSWNKCIKSQIASSDYEGIVTVWD V 
               
               
                   
                   
                 N TRQSVMMYEEHEKRAWSVDFSRTEPTRLISGSDDGKVK   
               
               
                   
                   
                 
                   VWCTRQETSVLNIDMKANICCVKYNPGSSYYVAVGSADH 
                 
               
               
                   
                   
                   HIHYYD LRN PSVPLYEFNGHRKTVSYVKFISTNE LASAS     
               
               
                   
                   
                     TDSTLRLWD     V R DNCLVRTFKGHTNEKNFVGLTVNSEYIA   
               
               
                   
                   
                   CGSETNGVFVYH KAISKPAAWHQFGSPDLDDSDDDTSHF 
               
               
                   
                   
                 ISAVCWKSESPTMLAANSQGTIKVLVLAP 
               
               
                   
               
               
                 218 
                 The amino acid sequence of SEQ ID 
                 MANYVDSKKNFKCVPALQQFYTGGPFRLSSDGSFLVCAC 
               
               
                   
                 487. The conserved G-protein beta 
                 NDEVKVVDLAT GSVKNTLEGDSELIVALALTPDNKYLFS   
               
               
                   
                 WD-40 repeat domains are 
                   ASRSTQIKFWD LSS ATCKRTWKAHNGPVADMACDASGGL   
               
               
                   
                 underlined. 
                   LATAGADRSILVWD VDG GYCTHSFRGHQGVVTTVIFHPD   
               
               
                   
                   
                   PHCLLLFSGSDDATVRIWD LVA KKCISVLEKHFSTVTSL   
               
               
                   
                   
                   AISENGWNLLSAGRDKVVNIWD LRDYHCRATIPTYEPLE 
               
               
                   
                   
                 AVCVLPTGSRLVSVMNQSRALPENRKKSGAAPVYFLTVG 
               
               
                   
                   
                 ERGIVRIWYSEGALCLYEQKSSDAIISSDKDELKGGFVS 
               
               
                   
                   
                 AVLLPLTQGVMCVTADQRFLFYNLDESDEGKCDLKVSKR 
               
               
                   
                   
                 LIGYNEEIVDLKFLGDEEKFLAVATNLEQVRMYDLSS MT   
               
               
                   
                   
                 
                   CVYELSGHTDIVLCLDTVVFSGHSLLASGSKDHTVRIWD 
                 
               
               
                   
                   
                 TES KSCICVAAGHMGAVGAVAFSKKAKNFFVSGSSDRTI   
               
               
                   
                   
                   KVWS FASVLDFGGISKSIK LSSQAAVAAHDKDINSVAVA   
               
               
                   
                   
                   PNDSLICTGSQDRTARIWR LPD LVPVLVLRGHKRGVWCV   
               
               
                   
                   
                   EFSPVDQCVMTASGDKTIKIWA LSD GSCLKTFEGHTASV   
               
               
                   
                   
                   LRASFLTRGTQFVSSGADGLLKLWT IKS NECIATFDQHE   
               
               
                   
                   
                   DKIWAMAVGKKTEMLATGGSDSLVNLWH DCTTTDEEEAL 
               
               
                   
                   
                 LKEEEAALKDQELLNALADTDYVKAIQLAFELRRPYKLL 
               
               
                   
                   
                 NVFTELYSKGHAQDQIQKVIRELGNEELRLLLEYVREWN 
               
               
                   
                   
                 TKPKFAHVAQFVLFQLFNVLPPKEIIEVQGISELLEGLI 
               
               
                   
                   
                 PYAQRHYSRIDRLMRSTFLLDYTLSSMSVLSPTETDLSS 
               
               
                   
                   
                 SNLLARTADPLHAQIDQFHPTHFPEPNLTPIQSLLDSGN 
               
               
                   
                   
                 TDSVEVTARRAKKKRVSGNDSEKTTVAEVKIGDMENAFD 
               
               
                   
                   
                 EPDVADQGSSRKHKPASSKKRKSIAVGNASIKRIASGNA 
               
               
                   
                   
                 VTIALQV 
               
               
                   
               
               
                 219 
                 The amino acid sequence of SEQ ID 
                 MESSCSSMNSNRHSTEKRCLRPLQKQGASMNKHSSDRFI 
               
               
                   
                 488. The conserved G-protein beta 
                 PARGSIDLDVARFMVTQKQKDNNDIHALSPSPSPSKKAY 
               
               
                   
                 WD-40 repeat domains are 
                 QKEMADTLLKNAGAADNNCRILSFNGKSSTVSQGSQENV 
               
               
                   
                 underlined. 
                 LANLSISRRARRYI PQSADRTLDAPDLLDDYYLNLLDWS   
               
               
                   
                   
                   STNVLSTALGNTVYLWD ASNS SISELLIADEEEGPVTSV   
               
               
                   
                   
                   SWAPDGSQIAVGLNNSVVQLWD SQ SNKKLRALKGHHDRV   
               
               
                   
                   
                   GALSWNGPILTTGGLDGIIINHD VRT RDHIVQTYKGHTQ   
               
               
                   
                   
                   EVCGLKWSPSGQQLASGGNDNLLYIWD KSMASHNP SSQY   
               
               
                   
                   
                 
                   FHQLDEHCAAVKALAWCPFQTNLLASGGGTSDGSIKFWN 
                 
               
               
                   
                   
                 TQ TGACLNTVDTHSQVCSLLWNRHERELLSSHGLNQNQL   
               
               
                   
                   
                   TLWK YP SMVKITELTGHTARVLHMAQSPDGYTVASAAAD   
               
               
                   
                   
                   ETLKFWQ VFGAPDASKKTKDTKGAFNMFHMHIR 
               
               
                   
               
               
                 220 
                 The amino acid sequence of SEQ ID 
                 MLDEIVADEEEEFNIWKKNTPLLYDVVITHALEWPSLTV 
               
               
                   
                 489. The conserved G-protein beta 
                 QWLPDRHQSPTKDYSLQKMIVGTHTSGDEPNYLMIAEVQ 
               
               
                   
                 WD-40 repeat domains are 
                 MPLQYSEDGNVGGFESTEAKVHIIQQINHEGEVNRAQYM 
               
               
                   
                 underlined. 
                 PQNSFIIATKTVSSDVYVFDYTKHSSNAPQERVCN PELI   
               
               
                   
                   
                   LKGHTNEGYSLSWSPLKEGQLLSGSNDAQICFWD INAAS 
               
               
                   
                   
                 GRKVVE AKQIFKVHEGAVEDVSWHLKHEYLFGSVGDDCH   
               
               
                   
                   
                   LLIWD TRTAAPNK PQHSVVAHESEVNSLAFNPFNEWLLA   
               
               
                   
                   
                   TGSADKTVKLFD LRKLSC SLHTFSNHTEEVFQIEWSPMN   
               
               
                   
                   
                   ETILASSGGDRRLMVWD LRRIGDEQTSEDAEDGPPR LIF   
               
               
                   
                   
                   IHGGHTSKISDFSWNLHDDWLIASVAEDNILQIWQ MAEN 
               
               
                   
                   
                 IYHDDADIL 
               
               
                   
               
               
                 221 
                 The amino acid sequence of SEQ ID 
                 MTKEDHGESRDEMGERMVNEEYKLWKKNTPFLYDLVITH 
               
               
                   
                 490. The conserved G-protein beta 
                 ALEWPSLTVQWLPPSCKQQQDIIKDDDIDHPNTQMVILG 
               
               
                   
                 WD-40 repeat domains are 
                 THTSDNEPNYLILAEVQLHDGTEDEDGDGDVKRPQDKMK 
               
               
                   
                 underlined. 
                 PGTSGGAMGKVRILQQINHQKEVNRARYMPQKPTIIATK 
               
               
                   
                   
                 TVNADVYVFDYSKHPSKPPQEGR CNPELRLQGHESEGYG   
               
               
                   
                   
                   LSWSPLKEGHLLSASDDAQICLWD ITAATKAPKV VEANQ   
               
               
                   
                   
                   IFRYHDGPVEDVAWHAIHDHLFGSVGDDHHLLLWD IRND 
               
               
                   
                   
                 S EKPLHIVEAHQAEVNCLAFNPFNEWIVATGSADRTVAL   
               
               
                   
                   
                   HD IRK LDKVLHTCAHHMEEVFQIGWSPQNGAILASCGSD   
               
               
                   
                   
                   RRLMVWD LSRIGDEQNPEDAEEAP PELLFIHGGHTSKIS   
               
               
                   
                   
                   DFSWNPAEEWVIASVAEDNILQVWQ MSEHIYNDDNDSPTA 
               
               
                   
               
               
                 222 
                 The amino acid sequence of SEQ ID 
                 MAMAMGDENAADPVEEFNIWKKNTPFLYDLVITHALEWP 
               
               
                   
                 491. The conserved G-protein beta 
                 SLTVQWLPDRHQSSTADYSLQKMIVGTHTSEDEPNYLMI 
               
               
                   
                 WD-40 repeat domains are 
                 AEVQIPLQNSEDNIIGGFESTEA KVQIIQKINHEGEVNK   
               
               
                   
                 underlined. 
                   ARYMPQNSFVIATKTVSSDVYVFD YSKHPSKAPQER VCN   
               
               
                   
                   
                   PELILKGHSNEGYGLSWSPLKEGYLLSGSNDAQICLWD I 
               
               
                   
                   
                 NAAFGKK VLEANQIFKVHEGAVGDVSWHLKHEYLFGSVG   
               
               
                   
                   
                   DDCHLLIWD MRTAA PNKPQQSVIAHQSEVNSLAFNPFNE   
               
               
                   
                   
                   WLLATGSMDKTVKLFD LRK LSCSLHTFSNHTDQVFQIEW   
               
               
                   
                   
                   SPMNETILASSGADRRLMVWD LARIGETPEDEEDG PPEL   
               
               
                   
                   
                   LFVHGGHTSKISDFSWNLNDDRVIASVAEDNILQIWQ MA 
               
               
                   
                   
                 ENIYHDDEDML 
               
               
                   
               
               
                 223 
                 The amino acid sequence of SEQ ID 
                 MGLFEPFRALGYITDGVPFAVQRRGIETFVTLSVGKAWQ 
               
               
                   
                 492. The conserved G-protein beta 
                 IYNCAKLIPVLVGPQMDKKIRALACWRDFTFAATGHDIA 
               
               
                   
                 WD-40 repeat domains are 
                 VFRRAHQVATWSGHKAKVTLLLSFGQHVLSVDLEGCLFI 
               
               
                   
                 underlined and the Trp-Asp (WD) 
                 WAVAEVNQN KPPIGQIQLGEKFSPSCIMHPDTYLNKVLI   
               
               
                   
                 repeats signature is in bold. 
                   GSEEGTLQLWN VNT RKKLYEFKGWGSSIRCCVSSPALDV   
               
               
                   
                   
                   VGIGCSDGKIHVHN LRYD EEIVTFMHSTRGAVTALSFRT   
               
               
                   
                   
                   DGQPLLAAGGSSGVISIWN LEKK KLQSVIKDAHDSSVCS   
               
               
                   
                   
                   LHFFANEPVLMSSATDNSIKMWI FDTTDGE ARLLKYRSG   
               
               
                   
                   
                   HSAPPMCIRYYGKGRHILSAGQDRAFRIFS VIQDQQSRE 
               
               
                   
                   
                 LSQGHVGKRAKKLKVKDEEIKLPPVIAFDAAEIRERDWC 
               
               
                   
                   
                 NVVTCHLDDPCAYTWRLQNFVIGEHILKPCLEDPTPVKS 
               
               
                   
                   
                 CSISACGNFAVLGTEGGWLERFNLQSGISRGTYI DIGEK   
               
               
                   
                   
                   RQCAHNGAVVGLACDATNTLLISGGYNGDIKVWD FK GRE   
               
               
                   
                   
                   LKFRWEIEVPLIKIVYHPGNGILATAADDMILRLFD VTA 
               
               
                   
                   
                 
                   MRLVRIFVGHMDRVTDLCFSGDGKW LLSSSMDGTIRVWD   
                 
               
               
                   
                   
                   I ISSRQLNAMHMDSAVTALSLSPGMDMLATTHVGHNGIY 
               
               
                   
                   
                 LWANRMIYSKATDIEPFISGKQVVKVSMPTVSSKRESEE 
               
               
                   
                   
                 GDEKRTIVAESNVNKSDVSGSLIGDSYSAQLTPELVTLA 
               
               
                   
                   
                 LLPKAQWQSLVNLDIIKMRNKPIEPPKKPEKAPFFLPSL 
               
               
                   
                   
                 PTLSGERIFIPSSMNGDGDQDETRNDKTVFEARGKKLGG 
               
               
                   
                   
                 ESLSFMQLLQSCAKIKDFTTFTNYLKGLSPSAVDMELRL 
               
               
                   
                   
                 LQIVDNENISETEHSVELQGIGMLLDYFVNEVSCNNNFE 
               
               
                   
                   
                 FVQALIRLFLKIHGETIRCQVSLQEKARKLLEIQSSTWE 
               
               
                   
                   
                 RLDTSFQNARCMITFLSSSQF 
               
               
                   
               
               
                 224 
                 The amino acid sequence of SEQ ID 
                 MIAAVCWVPKGVAKVLPDSAEPPTQEEIQELLKCNVVAE 
               
               
                   
                 493. The conserved G-protein beta 
                 SDDNEDSDEESEEMDTETDKNTDAVAKALAAANALGSQS 
               
               
                   
                 WD-40 repeat domains are 
                 SDFQRQHKVDDIANGLKELDMDHYDDEDEGIDIFGSGSL 
               
               
                   
                 underlined and the Trp-Asp (WD) 
                 GNCYYPANDMDPYLVEQDDDDEDEIEDMTIKPSDLIILS 
               
               
                   
                 repeats signature is in bold. 
                 ARNEDDVSHLEVWIYEEETEEGGSNMYVHHDIILPAFPL 
               
               
                   
                   
                 SLAWLDCNLKGGEKGNFVAVGTMQPEIELWDLDVLDEVE 
               
               
                   
                   
                 PAVVLGGAVKDEASGKTTKLKKKKKNK QAVNFKEGSHTD   
               
               
                   
                   
                   AVLGLAWNMEYRNV LASASADKSVKIWD     I VA EKCEHTMQ   
               
               
                   
                   
                   PHTDKVQAVAWNPNQATVLLSGSFDRSVIMMD MRA PTHS   
               
               
                   
                   
                   GIRWPVPADVESLAWDPHTDHSFMVSAEDGTVRGFD IRA 
               
               
                   
                   
                 AASTADFD GKPMFILHAHDKAVCAISYNPAAPSLLTTGS   
               
               
                   
                   
                   TDKMVKLWD ITNNQ PSCIASTNPNVGAVFSAAFSKNSPF   
               
               
                   
                   
                   LLATGGSKGILHVWD TLDNSEVARRFGKFRPQN 
               
               
                   
               
               
                 225 
                 The amino acid sequence of SEQ ID 
                 MIMDENEFCDIFSLRKRLCLLSSQEGEEEEELEAMSQLD 
               
               
                   
                 494. The conserved eukaryotic 
                 AGEFTVTGNEEVVAIAEDDVNTGILSQDLFSSQDYCTPS 
               
               
                   
                 protein kinase domain is 
                 QPQDSTDLDSKDKAPCPLSPVKSTIQRKRCRPELLSNPP 
               
               
                   
                 underlined. 
                 DSIQFSFQRLERVRSEESIQSSSQQLARVRSEVSSSDDF 
               
               
                   
                   
                 KTPKITASGQKNYVSQSALALRARVMSPPCIKNPYLDEN 
               
               
                   
                   
                 EELNEKIQRSTRRSPACVTPIQSGACLSRYRAD FHELEE   
               
               
                   
                   
                 
                   IGRGNFSRVYKALNRLDGCCYAVKCSQSELRLDTERKVA 
                 
               
               
                   
                   
                 
                   LMEVQSLAALGPHKNIVGYHTAWFENDHLYIQMELCDHN 
                 
               
               
                   
                   
                 
                   LTTANDRGILRTDTDFLEAVYQIAQALEFIHGRGVAHLD 
                 
               
               
                   
                   
                 
                   VKPENIYVRDGTYKLGDFGRATLINGTLHVEEGDARYMS 
                 
               
               
                   
                   
                 
                   REILNDNYEHLDKVDMFSLGATFFELLMRKQYPGSGKRI 
                 
               
               
                   
                   
                 
                   DRDTEIKIPILPGFSIYFQKLLQDLVSNDPGKRPSAKDV 
                 
               
               
                   
                   
                   LKNPIF NKVRGAKEV 
               
               
                   
               
               
                 226 
                 The amino acid sequence of SEQ ID 
                 MLAPALEMEPVEPQSLKKLSFKSLKRALDLFSPVHGQIA 
               
               
                   
                 495. The conserved G-protein beta 
                 PPDPESKKMRISYKLNFEYGGGSGSEDQVPKRKESGAAQ 
               
               
                   
                 WD-40 repeat domains are 
                 NQGQQAAGASNALALPGPEGSKIPPMEKSQNALTVGPSL 
               
               
                   
                 underlined and the Trp-Asp (WD) 
                 RPQGLNDVGLHGKGTAIISASGSSDRNLSTSAIMERLPS 
               
               
                   
                 repeats signature is in bold. 
                 RWPRPVWHPP WKNYRVISGHLGWVRSIAFDPSNQWFCTG   
               
               
                   
                   
                   SADRTIKIWD LAS GRLKLTLTGHIEQIRGLAVSSKHTYM   
               
               
                   
                   
                   FSAGDDKQVKCWD LEQ NKVIRSYHGHLSGVYCLALHPTI   
               
               
                   
                   
                   DILLTGGRDSVCRVWD IRS KMQIFALSGHDNTVCSVFAR   
               
               
                   
                   
                   PTDPQ VVTGSHDTTIKFWD     L RH GKTMTTLTNHKKSVRAM   
               
               
                   
                   
                   AQHPKENCFASASADNIKKFQ LPR GEFLHNMLSQQKTII   
               
               
                   
                   
                   NTMAVNEEGVMATGGDNGSLWFWD WKSGHNFQQAHT IVQ   
               
               
                   
                   
                   PGSLESEAGIYALSYDLTGSRLVSCEADKTIKMWK EDEL 
               
               
                   
                   
                 ATPETHPLNFKPPKDIRRF 
               
               
                   
               
               
                 227 
                 The amino acid sequence of SEQ ID 
                 MEEAAKEQSAGSGKPKLLRYGLRSAAKPKEDKKEEQLHQ 
               
               
                   
                 496. The conserved G-protein beta 
                 PPPPPPPQQQAAPAPAPAATRSSTSGSAGGRDRRPQQQH 
               
               
                   
                 WD-40 repeat domains are 
                 AVDEKYARWKSLVPVLYDWLANHNLLWPSLSCRWGPQLE 
               
               
                   
                 underlined. 
                 QATYKNRQRLYISEQTDGSVPNTLVIANCEVVKPRVAAA 
               
               
                   
                   
                 EHVSQFNEEARSPFIRKYKTIIHPGEVNRIRELPQNPNI 
               
               
                   
                   
                 VATHTDSPDVLIWDVESQPNRHAVYGATASRPNLILTGH 
               
               
                   
                   
                 QENAEFALAMCPAEPFVLSGGKDKTVVLWSIQDHITASA 
               
               
                   
                   
                 TDQTTNKSPGSGGSIIKKTGEGNEETGNGPS VGPRGIYC   
               
               
                   
                   
                   GHEDTVEDVAFCPSTAQEFCSVGDDSCLILWD ARIGT NP   
               
               
                   
                   
                   VAKVEKAHNGDLHCVDWNPHDNNLILTGSADNSVNMFD R 
               
               
                   
                   
                 RNLTSNGV GSPVYKFEGHKAAVLCVQWSPDKPSVFGSSA   
               
               
                   
                   
                   EDGLLNIWD YERVDKKVDRAPNAPAGLFFQHAGHRDKIV 
               
               
                   
                   
                 DFHWNTADPWTMVSVSDDCDTAGGGGTLQIWRMSDLIYR 
               
               
                   
                   
                 PEEEVLAELENFKAHVLECSKA 
               
               
                   
               
               
                 228 
                 The amino acid sequence of SEQ ID 
                 MAKDEEEFRGEMEERLVNEEYKIWKKNTPFLYDLVITHA 
               
               
                   
                 497. The conserved G-protein beta 
                 LEWPSLTVQWLPDREEPPGKDYSVQKMILGTHTSDNEPN 
               
               
                   
                 WD-40 repeat domains are 
                 YLMLAQVQLPLEDAENDARQYDDERGEIGGFGCANGKVQ 
               
               
                   
                 underlined. 
                 VIQQINHDGEVNRARYMPQNPFIIATKTVSAEVYVFDYS 
               
               
                   
                   
                 KHPSKPPQDGGCHPDLRLRGHNTEGYGLSWSPFKHGH LL   
               
               
                   
                   
                   SGSDDAQICLWDI NVPAKNKVLEAQQIFKVHEGVVEDVA 
               
               
                   
                   
                 WHLRHEYLFGSVGDDRHLLIWDLRTSATNKPLHSVVAHQ 
               
               
                   
                   
                 GEVNCLAFNPFNEWV LATGSADRTVKLFDL RKISSALHT 
               
               
                   
                   
                 FSCHKEEVFQIGWSPKNETI LASCSADRRLMVWDL SRID 
               
               
                   
                   
                 EFQTPEDALDGPPELLFIHGGHTSKISDFSWNPCEDWVI 
               
               
                   
                   
                 ASVAEDNILQIWQMAENIYHDEEDDMPPEEVV 
               
               
                   
               
               
                 229 
                 The amino acid sequence of SEQ ID 
                 MGKYMRKGKGVGEVAVMEVSQGSLGVRTRARTLAAASSQ 
               
               
                   
                 498. The conserved cyclin- 
                 KDHRRLGASKSVTTKHQSSAPPASPCVESSMHTCYLELR 
               
               
                   
                 dependent kinase inhibitor domain 
                 SRKLEKFSRCYHSAHGATSHGESKRSLSLSEPSRLAVSE 
               
               
                   
                 is underined. 
                 EARVASDKSSHRVLQQQSSVAHSRNNSATFSHNAKPAKA 
               
               
                   
                   
                 AQRKERRDDDHTSARPSEAPHEDEDGMEVEASFGENVMD 
               
               
                   
                   
                 LDSRERRTRETTPSSYTRDVETMETPGSTTRPPSNAGRR 
               
               
                   
                   
                 RFQTEGGHGTR NQFHVPTTNEIEEFFAGAEQQEQRRFTD   
               
               
                   
                   
                   RYNYDPVSDSPLPGRFEWVRLR P 
               
               
                   
               
               
                 230 
                 The amino acid sequence of SEQ ID 
                 MQNMEENVQSSWSLHGNKEICAR YEILKRVSSGTYLDVY   
               
               
                   
                 499. The conserved 
                 
                   RGRRKEDGLIVALKEVHDYQSSWREIEALQRLCGCPNVV 
                 
               
               
                   
                 serine/threonine protein kinase 
                 
                   RLYEVILEFLTSDLYSVIKSAKNKGENGIPEAEVKAWMI 
                 
               
               
                   
                 domain is underlined, and the 
                 
                   QILQGLANCHANW VIHRDLKPSNMLI SAYGILKLADFGS 
                 
               
               
                   
                 serine/threonine protein kinase 
                 
                   MSFLKRAIYEVEYELPQEDILADAPGERLMDEDDSVKGV 
                 
               
               
                   
                 active-site signature is in bold. 
                 
                   WNEGEEDSSTAVETNFDDMAETANLDLSWKNEGDMVMQG 
                 
               
               
                   
                   
                 
                   FTSGVGTRWYRAPDFLYGATIYGKEIDLWSLGCILGELL 
                 
               
               
                   
                   
                 
                   ILEPLFSGTSNIDQLSRLVKVLGLQQKKNWPGCSNLPDY 
                 
               
               
                   
                   
                 
                   RKLCFPGDGSPVGLKNHVPNCSDNMFSILERLVCYDPAA 
                 
               
               
                   
                   
                   RLNAKEIVENKYF VEDPYPVLTHELRVPSPLREENNFSE 
               
               
                   
                   
                 DWAKWKDMEVDSDLENIDEFNVVHSSDGFCIKFS 
               
               
                   
               
               
                 231 
                 The amino acid sequence of SEQ ID 
                 MADVPESLQQEKDEQGTDKNCCDGKFQKEIDIDDMEEEY 
               
               
                   
                 502. The conserved histone 
                 NESSIDDEEENLSDNVATNNMGTTPQGQACMAVTVEGIE 
               
               
                   
                 deacetylase family domain is 
                 HANSVGCGRNGREGSEEVTAAEDMGHVSIENIREQGRNR 
               
               
                   
                 underlined 
                 KSSEQLLALYEQEGLLEDDEDDDDVDWEPFEGVTVQMKW 
               
               
                   
                   
                 YCTNCTMANSDDSVHCDSCGEHRNSDILRQGFLASPYLP 
               
               
                   
                   
                 AESPSSSDVPDERLEESKCVMTTLTPSISPMIGVCCSSL 
               
               
                   
                   
                 QSE RRTVVGFDERMLLHSEIQMETYPHPERPDRLRAIAA   
               
               
                   
                   
                 
                   SLRAAGLFPGKCFSIPAREATCEELQTIHSLEHVNAVES 
                 
               
               
                   
                   
                 
                   TSCGMLSHLSPDTYANEHSSLAARLAAGLCADLAKAIMT 
                 
               
               
                   
                   
                 
                   GQAQNGFALVRPPGHHAGVKDSMGFCLHNNAAIAVSASR 
                 
               
               
                   
                   
                 
                   VVGAKKVLIVDWDVHHGNGTQEIFEADQSVLYISLHRHG 
                 
               
               
                   
                   
                 
                   EGFYPGSGAVTEVGSSKGEGYSVNIPWKCGGVGDNDYIF 
                 
               
               
                   
                   
                 
                   AFQHAVLPIAEQFEPDLTIISAGFDAAKGDPLGRCEVTP 
                 
               
               
                   
                   
                 
                   DGFAHMAQMLSCLSKGKMLVILEGGYNLRSISASATAVI 
                 
               
               
                   
                   
                   KVLLG DNPKALPIDIQPSKGGLQTLLEVFEIQSKYWSSL 
               
               
                   
                   
                 KGHDQKLRSQWEAQYGSKKRKVIRKRHMHIVGGPVWWKW 
               
               
                   
                   
                 GRKRVVYYHWFARVSSRKHL 
               
               
                   
               
               
                 232 
                 The amino acid sequence of SEQ ID 
                 MASGAGAAGVVEWHQKPPNPKNP VVFFDVTIGTIPAGRI   
               
               
                   
                 503. The conserved cyclophilin- 
                 
                   KMELFADIVPRTAENFRQFCTGEYRKAGIPIG YKGCHFH   
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
                 
                     RVIKDFMIQAG DFVKGDGSGCISIYGSKFEDENFIAKHT 
                 
               
               
                   
                 isomerase family domain is 
                 
                   GPGLLSMANSGPNTNGCQFFLTCAKCDWLDNKHVVFGRV 
                 
               
               
                   
                 underlined and the cyclophilin- 
                 
                   LGEGLLVLRKIENVQTGQHNRPKLPCVIAECGEM 
                 
               
               
                   
                 type peptidyl-prolyl cis-trans 
               
               
                   
                 isomerase signature is in bold. 
               
               
                   
               
               
                 233 
                 The amino acid sequence of SEQ ID 
                 MDHYYQDDFDYLVDDEMVDFADDVEDDVRTRRRSDIDSD 
               
               
                   
                 505. The conserved G-protein beta 
                 SENDFDSNNKSPDTTALQAKRGKDIQGIPWNRLNFTREK 
               
               
                   
                 WD-40 repeat domain is underlined. 
                 YRETRLQQYKNYENLPRPRRSRNLDKECTNFERGSSFYD 
               
               
                   
                   
                 FRHNTRSVKATIVHFQLRNLVWATSKHNVYLMQNYSIMH 
               
               
                   
                   
                 WSSLKQKGEEVLNVAGPIIPSVKHPGSSPQGLTRVQVSA 
               
               
                   
                   
                 MSVKDNLVVAGGFQGELICKYLDKPGVSFCTKISHDENG 
               
               
                   
                   
                 ITNAVEIYNDASGATRLMTANNDLAVRVFDTEKFTVLER 
               
               
                   
                   
                 FSFPWSVNHTSVSPDGKLVAVLGDNADCLLADCKT GKTV   
               
               
                   
                   
                   GTLRGHLDYSFAAAWHPDGYILATGNQDTTCRLWD VRKL 
               
               
                   
                   
                 SSSLAVLKGRMGAIRSIRFSSDGRFMAMAEPADFVHLYD 
               
               
                   
                   
                 TRQNYTKSQEIDLFGEIAGISFSPDTEAFFVGVADRTYG 
               
               
                   
                   
                 SLLEFNRRRMNYYLDSIL 
               
               
                   
               
               
                 234 
                 The amino acid sequence of SEQ ID 
                 MDCSGDEEEEQFFESLEEMLSPSDSGSEAADNETGCRNA 
               
               
                   
                 506. The conserved G-protein beta 
                 DARSKYEIWKRAPSSIQERRQRFLVRMGLANPSELGNQV 
               
               
                   
                 WD-40 repeat domains are 
                 NSTSAESTCSTETANIPNGIERLRENSGAVLRTAGSSGR 
               
               
                   
                 underlined. 
                 KTHCKNVINIGLREGSVRSSSSSNGTPDVGEDNGEFGGT 
               
               
                   
                   
                 IFSRSGGTWECMCKIKNLDSGKEFVVDELGQDGLWNKLR 
               
               
                   
                   
                 EVGTDRQLTMDEFERSLGLSPLVQELMRRESGVAQADCN 
               
               
                   
                   
                 GVHHHDAEISSSKRRSWLKALKSAAYSMRRPKEDQSNYD 
               
               
                   
                   
                 SERSGRRSGSFDVPWGKPQWTKVRHYRKRYKEFTALYMG 
               
               
                   
                   
                 QEIEAHEGSIWTMKFSLDGRYLASAGQDCVIHVREVIES 
               
               
                   
                   
                 MRTFGADTPDLYASSAYFSMNGLQELVPLSIEDHANKMK 
               
               
                   
                   
                 RGKIIGSKKSSNSDCIVLPNKVFQLS EEPVCSFHGHLLD   
               
               
                   
                   
                   VFDLSWSPSQYLLSSSMDKTVRLWK LGH ESCLKVFSHND   
               
               
                   
                   
                   IVTCIQFNPVDERYFISGSLDGKARIWS IPDRQVVDWSD 
               
               
                   
                   
                 LREMVTAVCYTPDGQGGLVGSIKGSCRFYNTSGNKLQLE 
               
               
                   
                   
                 NQLNVRSKKKKSSGKKITGFQFAPGGDSQKVLITSADSR 
               
               
                   
                   
                 VRVYNGSELVCKYKGFRNTCSQISASFAPNGQHFVCASE 
               
               
                   
                   
                 DSRVYIWNHESPRGSGARHEKSSWSHEHFLSQGVSVAIP 
               
               
                   
                   
                 WSGMKLQPPVWNSPEFMLGQRHNLLSLQGGKDVGCQNGL 
               
               
                   
                   
                 LSREAGEGQESETPLHYISQVSHSCGSQNMVDRDGQDDL 
               
               
                   
                   
                 SRYSACISDSRLSSFMAFPESPGNPDDLNSKVFFSDSSS 
               
               
                   
                   
                 KGSATWPEEKLPPTRKQSRSNSTSSHYDTLKTHLGNTIQ 
               
               
                   
                   
                 GQSGASAAVAWGLVIVTAGHGGEIRSFQNYGLPVRL 
               
               
                   
               
               
                 235 
                 The amino acid sequence of SEQ ID 
                 MPSIPAIGEFTVCEINRELLTTKDESDTQAKDAYAKILG 
               
               
                   
                 507. The conserved G-protein beta 
                 LVFPPISFQIEEGFGSASRQQFDQDLDREDTIVTPSTSE 
               
               
                   
                 WD-40 repeat domain is underlined. 
                 GTNALQEGGLLLKGVSVLKNILASSFGPIFSPNDTKVLK 
               
               
                   
                   
                 KVELLQGISWHRHKHILAFISGSNQVTVHDFQDPEWR ES   
               
               
                   
                   
                   SLLVSESQRGIEALEWRPNGGTTLSVACRGGICIWS ASY 
               
               
                   
                   
                 PGSVAPVRSGVASFLGTSTRGSSVRWTLVDFLQIPGGKA 
               
               
                   
                   
                 VTALSWSPTGRLLASASREDSSFTIWDVAQGVGTPLRRG 
               
               
                   
                   
                 LGGISLLKWSPTGDYLFSAKPNGTFYLWETNTWTLEQWS 
               
               
                   
                   
                 SSGGCVISATWGPDGRMLFMAFSESTTLGSLHFAGRPPS 
               
               
                   
                   
                 LDAHLLPMELPEIGSITGGFGNIEKMAWDGCGERLAVSY 
               
               
                   
                   
                 TGGDLMYVGLIAIYDTRRTPFISASLVGFIRGPGEQVKP 
               
               
                   
                   
                 LAFAFHDKFKQGPLLSVCWSSGLCCTYPLIFRAH 
               
               
                   
               
               
                 236 
                 The amino acid sequence of SEQ ID 
                 MEEENAKHTEETRQVQVRFTTKLQPALRVPTTSIAIPAH 
               
               
                   
                 508. The conserved G-protein beta 
                 LTRYGLSDIVNTLLGNDKPQPFDFLVESELVRTSLEKLL 
               
               
                   
                 WD-40 repeat domains are 
                 LIKGISAEKILNIEYILAVVPPKQEEPSLHDDWVSVVDG 
               
               
                   
                 underlined. 
                 SYPNFIFSGSFDSIGRIWKGEGLCTHVLEGHRDAITSAA 
               
               
                   
                   
                 FIMPSDSSDSFIN LATASKDRTLRLWQF KPNEHMTNGKM 
               
               
                   
                   
                 VRPYKLLKGHTSSVQTVSACPRRNLICSGSWDCSIKIWQ 
               
               
                   
                   
                 TAGEMDIESNAGSVKKRKLEDSTEQIISQIEASRTLEGH 
               
               
                   
                   
                 SQCVSSVVWLEKDT IYSASWDHSVRSWDV ETGVNSLTVG 
               
               
                   
                   
                 CRKALHCLSIGGEGSALIAAGGADSVLRIWDPRMPGTFT 
               
               
                   
                   
                 PILQLSSHKSWITACKWHPKSRHH LISASHDGTLKLWDV   
               
               
                   
                   
                 RSKVPLTTLEAHKDKVLCADWWKEDCVISGGADSTLQIF 
               
               
                   
                   
                 SNLNLT 
               
               
                   
               
               
                 237 
                 The amino acid sequence of SEQ ID 
                 MNRLRSKRNHILELRLGQSEPEKEATLASNRSRGTNAPI 
               
               
                   
                 509. The conserved RING-type zinc 
                 VVEDDDDVVVSSPRSFALARSSVSQRSSRIPIVNEEDLE 
               
               
                   
                 finger is underlined. 
                 LRLGLAVTGRTSAEHNPRRRHGRVPPNKPIVLCDDAGEA 
               
               
                   
                   
                 DQSSSKKRRTGQQLSSDVQSDESKEVKLTCAICISTMEE 
               
               
                   
                   
                 ETSTI CGHIFCKKCI TNAIHRWKRCPTCRKKLAINNIIHR 
               
               
                   
                   
                 IYISSSTG 
               
               
                   
               
               
                 238 
                 The amino acid sequence of SEQ TD 
                 MEEPPPPAVLPSSEDTSIVSSHSFVNAPPTVPVGLDASI 
               
               
                   
                 510. The conserved G-protein beta 
                 PQISTPGINQPGLTIPVPPEAAPLTASLVAASAGMPPAV 
               
               
                   
                 WD-40 repeat domains are 
                 VPSFVRPAIVAHPSVMPPPSMPLAALPMPVASAVPVAAP 
               
               
                   
                 underlined and the splicing factor 
                 HFPPSTPNDNSITPSMPVPTPIVASSSVPPSVTIPGIAP 
               
               
                   
                 motif is in bold. 
                 LPFIAPIPVPSSRPVAPSPFMPPARPLGASVSVAMDVDN 
               
               
                   
                   
                 TDEQDQDADNKGESPSSSPDHPEDPSAAEYEITEESRKV 
               
               
                   
                   
                 RERQEQAIQELLLRRRAYALAVP TNDSSVRARLRRLNEP   
               
               
                   
                   
                   ITLFGEREMERRDRLRALMAKLDAEGQLEKLMKVQEEE E 
               
               
                   
                   
                 AAANVDAEEVQEMEGPQVYPFYTEGSQELLKARTEITKF 
               
               
                   
                   
                 SLPRAVSRLQRARRKREDPDEDEDEELKCVLQQSAQINM 
               
               
                   
                   
                 DCSEIGDDRPLSGCAFSSDGTLLATSAWSGVTKLWSVPN 
               
               
                   
                   
                 
                   INKVATLKGHTERVTDVAFSPTNCHLATACADRTAMLWN 
                 
               
               
                   
                   
                 SE GVLMKTYEGHLDRLARLAFHPSGLYLGTASFDKTWRL   
               
               
                   
                   
                   WD VNT GIELLLQEGHSRSVYGIAFQCDGSLAATCGLDGL   
               
               
                   
                   
                   ARIWD LRT GRSILALEGHVKPVLGIDFSPNGYHLATGSE   
               
               
                   
                   
                   DHTCRIWD LRK RQSVYIIPAHSHLVSQVKFEPQEGYFLV   
               
               
                   
                   
                   TASYDSTAKVWS ARD FKSIKVLAGHEAKVTSVDITADGQ   
               
               
                   
                   
                   YIATVSHDRTIKLWS SKNSTNDMNIG 
               
               
                   
               
               
                 239 
                 The amino acid sequence of SEQ ID 
                 MKR AYKLQEFVAHASNVNCLKIGKKSSRVLVTGGEDHKV   
               
               
                   
                 511. The conserved G-protein beta 
                   NMWA IGK PNAILSLSGHSSAVESVTFDSAEALVVAGAAS   
               
               
                   
                 WD-40 repeat domains are 
                   GTIKLWD LEE AKIVRTLTGHRSNCISVDFHPFGEFFASG   
               
               
                   
                 underlined and the Trp-Asp (WD) 
                   SLDTNLKIWD IRR KGCIHTYKGHTRGVNSIRFSPDGRWV   
               
               
                   
                 repeats signature is in bold. 
                   VSGGEDNIVKLWD LTA GKLMHDFKCHEGQIQCMDFHPQE   
               
               
                   
                   
                   FL LATGSADRTVKFWD     L ET FELIGSAGPETTGVRAMIFN   
               
               
                   
                   
                   PDGRTLLTGLHESLKVFS WEPLRCYDAVDVGWSKLADLN 
               
               
                   
                   
                 IHEGKLLGCSYNQSCVGVWVVDISRVGPYAAGNVSRTNG 
               
               
                   
                   
                 HNEAKLASSGHPSVQQLDNNLKTNMARLSLSHSTESGIK 
               
               
                   
                   
                 EPKTTTSLTTTEGLSSTPQRAGIAFSSKNLPASSGPPSY 
               
               
                   
                   
                 VSTPKKNSTSRVQPTTNFQTLSRPDIVPVIVPRSNSLRP 
               
               
                   
                   
                 ETTSDAKKEMNNFGRVVPSTVSTKSTDVIKSGSNRDESD 
               
               
                   
                   
                 KIDSINQKRMTGNDKTDLNIARAEQHVSSRLDNTNTSSV 
               
               
                   
                   
                 VCDGNQPAARWIGAAKFRRNSPVDPVVSPHDRSPTFPWS 
               
               
                   
                   
                 ATDDGVTCQPDRQVTAPELSKRVVEPGRARALVASWETR 
               
               
                   
                   
                 EKALTADTPVLVSGRPPTSPGVDMNSFIPRGSHGTSESD 
               
               
                   
                   
                 LTVSDDNSAIEELMQQHNAFTSILQARLTKLQVIRRFWQ 
               
               
                   
                   
                 RNDLKGAIDATGKMGDHSVSADVISVLIERSEIFTLDIC 
               
               
                   
                   
                 TVILPLLTRLLQSETDRHLTVAMETLLVLVKTFGDVIRA 
               
               
                   
                   
                 TISATPTIGVDLQAEQRLERCNLCYVELENIKQILVPLI 
               
               
                   
                   
                 RRGGAVAKSAQELSLALQEV 
               
               
                   
               
               
                 240 
                 The amino acid sequence of SEQ ID 
                 MAGSDENNPGVVGGAHVQEGLRVGAGKMGAGNVQQRRAL 
               
               
                   
                 512. The conserved cyclin N- and 
                 SNINSNIIGAPPYPCAVNKRVLSEKNVNSENDLLNAAHR 
               
               
                   
                 C-terminal family domains are 
                 PITRQFAAQMAYKQQLRPEENKRTTQSVSNPSKSEDCAI 
               
               
                   
                 underlined. 
                 LDVDDDKMADDFPVPMFVQHTEAMLEEIDRMEEVEMEDV 
               
               
                   
                   
                 AEEPVTDIDSGDKENQLAVVEYID DLYMFYQKAEASSCV   
               
               
                   
                   
                 
                   PPNYMDRQQDINERMRGILIDWLIEVHYKFELMDETLYL 
                 
               
               
                   
                   
                 
                   TVNLIDRFLAVQPVVKKKLQLVGVTAMLLACKYEEVSVP 
                 
               
               
                   
                   
                   VVEDLILISDRAYSRKEVLEMERLMVNTLHFNMS V PTPY   
               
               
                   
                   
                 
                   VFMRRFLKAAQSDKKLELLSFFIIELSLVEYDMLKFPPS 
                 
               
               
                   
                   
                 
                   LLAASAIYTALSTITRTKQWSTTCEWHTSYSEEQLLECA 
                 
               
               
                   
                   
                 
                   RLMVTFHQRAGSGKLTGVHRKYSTSKFGHAARTEPANFL 
                 
               
               
                   
                   
                 LDFRL 
               
               
                   
               
               
                 241 
                 The amino acid sequence of SEQ ID 
                 MQAPREGKSAAAIVGMGKYMKKSKAIPRDVSLLEASPRS 
               
               
                   
                 513. The conserved cyclin- 
                 PSATGVRTRAKTLASRRLRRASQRRPPPPAAAAAAAAPS 
               
               
                   
                 dependent kinase inhibitor domain 
                 LDASPCPFSYLQLRSRRLRRPRLAPSPEARIDEGPAGSG 
               
               
                   
                 is underlined. 
                 SRGSRDASCSARTASSSGGVEGEGACVGRGDRGNGGECV 
               
               
                   
                   
                 RDAAVDASYGENDLEIEDRDRSTRESTPCSLIRDSNANT 
               
               
                   
                   
                 PPGSTTRQQSSCTAHRTQMS ILRSIPTSDEMEEFFAYAE   
               
               
                   
                   
                   QRQQRSFIEKYNFDIVKDRPLPGRFEWVQVI P 
               
               
                   
               
               
                 242 
                 The amino acid sequence of SEQ ID 
                 MDGHSSHLAAQNRSRGSQTPSPSHSAASASATSSIHLKR 
               
               
                   
                 514. The conserved GCN5-related N- 
                 KLSAANASAASAAAAAAAAAAAADDHAPPFPPSSISADT 
               
               
                   
                 acetyltransferase family domain is 
                 RDGALTSNDDLESISARGGGAGDDSDDDSDDEEEDDGDN 
               
               
                   
                 underlined and the bromodomain is 
                 DGGSSLRTFTAARLENVGPAAARNRKIKAESNATVKVEK 
               
               
                   
                 in bold. 
                 EDSAKDGGNGAGVGALGPAATSGAGSGSGTVPKEDAVKI 
               
               
                   
                   
                 FTENLQASGAYSAREENLKREEEAGRLKFECLSNDGVDD 
               
               
                   
                   
                 HMVWLIGLKNIFARQLPNMPKEYIVRLVMDRNHKS VMVI   
               
               
                   
                   
                 
                   RRNLVVGGITYRPYASQKFGEIAFCAIKADEQVKGYGTR 
                 
               
               
                   
                   
                   LMNHLKQHARDVDGLTHFLTYADNNAVGYFIKQGFT KEI 
               
               
                   
                   
                 YLDKDRWHGYIKDYDGGILMECKIDPKLPYTDLSTMVRR 
               
               
                   
                   
                 QRQAIDEKIRELSNCHIVYQGIDFQKRDAGVPQNTIKME 
               
               
                   
                   
                 DIPGLREAGWTPDQWGYSRFRGLSDQKR LTFFIRQLLKV   
               
               
                   
                   
                 
                   LNDHSDAWPFKEPVDAREVPDYYDIIKDPMDLKTMTKRV 
                 
               
               
                   
                   
                 
                   ESEQYYVTLEMFIADVKRMFANARTYNSPDTIYFKIATR 
                 
               
               
                   
                   
                 LEAHFQSKVQSNLQSGAGKIQQ 
               
               
                   
               
               
                 243 
                 The amino acid sequence of SEQ ID 
                 MFNGMMDPELFKLAQEQMNRMSPAELAKIQQQMMSNPEL 
               
               
                   
                 515. The conserved TPR repeat 
                 MRMASESMKNMRPEDLRQAAEQLKHVRPEEMAEIGEKMA 
               
               
                   
                 domain is underlined 
                 NASPEEIAAVRARADAQMTYEINAAKILKKEGNELHSQG 
               
               
                   
                   
                 RFKDASQKYLRAKNNLKGIPSSEGKNLLLACSLNLMSCY 
               
               
                   
                   
                 LKTRQYEECIKEGSEALACEEKN LKAFYRRGQAYRELGQ   
               
               
                   
                   
                   LKDAVSDLRKAHEISPDD ETIAQVLRDTEESLTKEGGSA 
               
               
                   
                   
                 PRGVVIEEITEEDETLASVNHESPSEYSEKRHQESEDAH 
               
               
                   
                   
                 KGPINGDIMGQMTNSESLKALKGDPDAIRSFQNFISNAD 
               
               
                   
                   
                 PTTLAAMGAGNAGEVSPDLIKTASSMIGKMSAEELQKMI 
               
               
                   
                   
                 QLASSFPGENPYVTRNSDSNSNSFGNGSIPNVSPDMLKT 
               
               
                   
                   
                 ASDMMSKMSPDDLQRMFEMASSSRGKDPSLDANHASSSS 
               
               
                   
                   
                 GANLAANLNHILGESEPSSSYHIPSSSRNISSSPLSNFP 
               
               
                   
                   
                 SSPGDMQEQIRNQMKDPAMRQMFTSMMKNMSPEMMANMG 
               
               
                   
                   
                 KQFGLELSPEDAAKAQEAMSSLSPEMLDKMMRWADRAQR 
               
               
                   
                   
                 GVETAKKTKNWLLGRPGMILAICMLLLAVILHRLGFIGS 
               
               
                   
               
               
                 244 
                 The amino acid sequence of SEQ ID 
                 MIAAISWVPRGASKAVPEVAEPPSKEEIEEILKSGVVER 
               
               
                   
                 516. The conserved G-protein beta 
                 SGDSDGEEDDENMDAVASEKADEVSTALSAADALGRISK 
               
               
                   
                 WD-40 repeat domains are 
                 VTKAGSGFEDIADGLRELDMDNYDEEDEDVKLFSTGLGD 
               
               
                   
                 underlined. 
                 LYYPSNDMDPYLKDKDDDDDTEEIEDLSIKPMDSLIVCA 
               
               
                   
                   
                 RTDDEVNLLEVYLLEPSLSDESNMYVHHEVVISEFPLCT 
               
               
                   
                   
                 AWLDCPIKGGDKGNF IAVGSMEPAIEIWDL DIIDAVEPC 
               
               
                   
                   
                 LVLGGQEELKKKKKKGKKASIKYKEGSHTDSVLGLAWNK 
               
               
                   
                   
                 EFRNI LASASADRQVKIWDV AAGKCNITMEHHTDKVQAV 
               
               
                   
                   
                 AWNHHAPQVLLSGSFDHSVVMKDGRIPSHSGYRWSVTAD 
               
               
                   
                   
                 VESLAWDPHSEHFFVVSLEDGTVRGFDVRAAISNSASQS 
               
               
                   
                   
                 LPSFTLHAHEKAVSTISYNPAAPNL LATGSTDKMVKLWD   
               
               
                   
                   
                   L SNNQPSCIASRNPKAGAVFSVSFSEDSPLLLAIGGSKG 
               
               
                   
                   
                 RLEVWDTSSDAAVSRRFGKHGKPKTAEPGS 
               
               
                   
               
               
                 245 
                 The amino acid sequence of SEQ ID 
                 
                   MKFCKKYQEYMQGQEGKKLPGLGFKKLKKILKRCRRRDS 
                 
               
               
                   
                 517. The conserved Zn-finger, RING 
                 
                   LHSQKALQAVQNPRTCPAHCSVCDGSFFPSLLEEMSAVL 
                 
               
               
                   
                 domain is underlined, and the SPX, 
                 
                   GCFNKQAQKLLELHLASGFQKYLMWFKGKLRGNHVALIQ 
                 
               
               
                   
                 N-terminal is in bold 
                 
                   EGKDLVTYALINAIAIRKILKKYDKIHLSTQGQAFKSQV 
                 
               
               
                   
                   
                   Q RMHMEILQSPWLCELIAFHINVRETKANSGKGHALFEG 
               
               
                   
                   
                 CSLVVDDGKPSLSCELFDSIKLDIDLT CSICLDTVFDSV   
               
               
                   
                   
                   SLTCGHIYCYMCACSAASVTIVDGLKAAEPKEKCPLC RE 
               
               
                   
                   
                 ARVFEGAVHLDELNILLSRSCPEYWAERLQTERVERVRQ 
               
               
                   
                   
                 AKEHWESQCRAFMGVE 
               
               
                   
               
               
                 246 
                 The amino acid sequence of SEQ ID 
                 MVSTQSTRENPSIFFPPPLKPWLLPVVLSLSLSRQLGMA 
               
               
                   
                 518. The conserved G-protein beta 
                 AAAAASLPFKKNYRSSQALQQFYAGGPFAVSSDGSFIAC 
               
               
                   
                 WD-40 repeat domains are 
                 NCGDSIKIVDSSNASLRPSIDCGSDTITALSLSPDGKLL 
               
               
                   
                 underlined. 
                 FSAGHSRQIRVWDLSTSTCLRSWKGHDGPVMSMACPVSG 
               
               
                   
                   
                 GLLATGGADRKVMVWDVDGGFCTHFFKGHDGVVSTVLFH 
               
               
                   
                   
                 PDSNRSL LFSGSDDGTIRVWDL LAKKCASTLRGHDSTVT 
               
               
                   
                   
                 SLAFSEDGLTLLAAGRDKVVSLWDLHNYACKKTIPMYEV 
               
               
                   
                   
                 LESVCVIHSGTVLASQLGLDDQLKVTKESAQNIHFITVG 
               
               
                   
                   
                 ERGILRIWKSEGSVCLFKQEHSDVTVISDEDDSRSGFTA 
               
               
                   
                   
                 AVMLPLDQGLLCVTADQQFLFYYPEKHPEGIFSLTLCRR 
               
               
                   
                   
                 LVGYNEEIVDMKFLGEEENFLAVATNLEQVRVYELASMS 
               
               
                   
                   
                 CSYVLAGHTETVLCLDTCISSSGRTL IVTGSKDNSVRLW   
               
               
                   
                   
                   DS ESRHCIGVGVGHMGAVGAVAFSRKRQDF FVSGSSDRT   
               
               
                   
                   
                   LKVWSL DGISEDGVDSTNLKAKAVVAAHDKDINSVAVAP 
               
               
                   
                   
                 NDSLVCSGSQDRTACVWRLPDLVSVVVLKGHKRGIWSVE 
               
               
                   
                   
                 FSPVDQCVLTASGDKTVKIWAISDGSCLKTFEGHVSSVL 
               
               
                   
                   
                 RASFLTRGTQFVSCGADGLVKLWTVRTNECIATYDQHSD 
               
               
                   
                   
                 KVWALAVGKKTEMLATGGSDAVVNLWYDSTASDKEDAFR 
               
               
                   
                   
                 KEEEGVLKGQELENAVSDADYTKAIELALELRRPHKLFE 
               
               
                   
                   
                 LFSELCRTREVGDRVERILSALSGEEVCLLLEYIREWNA 
               
               
                   
                   
                 KPKLCHVAQSVLSQVFRILSPTEIVEIKGIGELLEGLIP 
               
               
                   
                   
                 YSQRHFSRIDRLVRSTYLLDYTLTGMSVIEPEADRSAVN 
               
               
                   
                   
                 DGSPDKSGLEKLEDGLLGENVGEEKIQNKEELESSAYKK 
               
               
                   
                   
                 RKLPRSKDRSKKKSKNVVYADAAAISFRA 
               
               
                   
               
               
                 247 
                 The amino acid sequence of SEQ ID 
                 MDSAPRRKSGGINLPSGMSETSLRLDGFSGSSSSFRAIS 
               
               
                   
                 519. The conserved G-protein beta 
                 NLTSPSKSSSISDRFIPCRSSSRLHTFGLVERGSPVKEG 
               
               
                   
                 WD-40 repeat domains are 
                 GNEAYSRLLKAELFGSDFGSLSPAGQGSPMSPSKNMLRF 
               
               
                   
                 underlined. 
                 KTESSGPNSPFSPSILRQDSGFSSEASTPPKPPRKVPKT 
               
               
                   
                   
                 PHKVLDAPSLQDDFYLNLVDWSSQNTLAVGLGTCVYLWS 
               
               
                   
                   
                 ASNSKVTKLCDLGPNDGVCAVQWTREGSYISIGTSLGQV 
               
               
                   
                   
                 QIWDGTQCKRVRTMGGHQTRTGVLAWNSRILASGSRDRV 
               
               
                   
                   
                 ILQHDLRV PNEFIGKLVGHKSEVCGLKWSHDDRELASGG   
               
               
                   
                   
                   NDNQLLVWN QH SQQPVLKLTEHTAAVKAIAWSPHQNGLL   
               
               
                   
                   
                   ASGGGTADRCIRFWN TTNGHQTSSVDTGSQVCNLAWSKN 
               
               
                   
                   
                 VNELVSTHGYSQNQIMVWKYP SMAKVATLTGHSLRVLYL   
               
               
                   
                   
                   AMSPDGQTIVTGAGDETLRFWN VFPSAKAPAPVKDTGLW 
               
               
                   
                   
                 SLGRTHIR 
               
               
                   
               
               
                 248 
                 The amino acid sequence of SEQ ID 
                 MEDEAEIYDGVRAQFPLTFGKQSKPQTSLESVHSATRRG 
               
               
                   
                 520. The conserved G-protein beta 
                 GPAPAPAPASSSSLPSTTSPSAAGGAGKSSGLPSLSSSS 
               
               
                   
                 WD-40 repeat domains are 
                 TAWLEGLRAGNPRAGREAGIGSRGGDGEDGGRAMIGPPR 
               
               
                   
                 underlined. 
                 PPPGFSANDDGGGEDDDDDGDGVMVGPPPPPPGNLGDGD 
               
               
                   
                   
                 DDEEEEEAMIGPPRPPVVDSDEEEEEEEEENRYRLPLSN 
               
               
                   
                   
                 EIVLKGHNKIVSALAVDPTGSRVLSGSYDYTVRMFDFQG 
               
               
                   
                   
                 MNSRLSSFRDFEPVEGHQVRNLSWSPTADRFLCVTGSAQ 
               
               
                   
                   
                 AKIYDRDGLTLGEFVKGDMYIRDLKNTKGHITGLTWGEW 
               
               
                   
                   
                 HPKTKET ILTSSEDGSLRIWDV NDFKSQKQVIKPKLARP 
               
               
                   
                   
                 GRVPVTTCTWDREGKC IAGGIGDGSIQIWNL KPGWGSRP 
               
               
                   
                   
                 DIHVEQAHADDITGLKFSSDGKI LLTRSFDDSLKVWDL R 
               
               
                   
                   
                 LMKNPLKVFEDLPNHYAQTNIACSPDEQLFLTGTSVERE 
               
               
                   
                   
                 STIGGLLCFFDRSKLELVSRIGISPTCSVVQCAWHPRLN 
               
               
                   
                   
                 QIFATSGDKSQGGTHVLYDPTLSERGALVCVARAPRKKS 
               
               
                   
                   
                 VDDFELKPVIHNPHALPLFRDQPSRKRQREKILKDPLKS 
               
               
                   
                   
                 HKPELPMNGPGHGGRVGASKGSLLTQYLLKQGGMIKETW 
               
               
                   
                   
                 MDEDPREAILKHADAAEKNPKFTRAYAETQPDPVFAKSD 
               
               
                   
                   
                 SEDEDK 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 12 
               
             
            
               
                   
               
               
                   Eucalyptus  in silico Data. 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 SEQ 
                 ConsID 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 ID 
                 eucSpp 
                 Family 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 8 
                 9 
                 10 
                 11 
                 12 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1 
                 3910 
                 Cyclin- 
                   
                 0.25 
                   
                   
                   
                 0.11 
                   
                 0.20 
                   
                   
                   
                 0.73 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 2 
                 19213 
                 Cyclin- 
                   
                   
                   
                   
                   
                   
                   
                 0.59 
                   
                   
                   
                 0.64 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 3 
                 36800 
                 Cyclin- 
                   
                   
                   
                   
                   
                   
                 0.11 
                 0.36 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 4 
                 40260 
                 Cyclin- 
                   
                   
                   
                 0.85 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 5 
                 41965 
                 Cyclin- 
                   
                   
                   
                   
                 0.35 
                   
                   
                   
                   
                   
                   
                 0.86 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 6 
                 2906 
                 Cyclin- 
                   
                 0.93 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 0.81 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 7 
                 1518 
                 Cyclin- 
                   
                 0.08 
                 0.28 
                 0.08 
                   
                 0.06 
                 0.11 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 8 
                 8078 
                 Cyclin- 
                   
                   
                   
                   
                 0.17 
                   
                   
                   
                   
                   
                   
                 3.20 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 9 
                 9826 
                 Cyclin- 
                   
                   
                 0.36 
                 0.23 
                   
                   
                 0.15 
                 0.04 
                   
                 0.24 
                   
                 0.43 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 10 
                 10364 
                 Cyclin- 
                   
                   
                   
                   
                   
                 0.11 
                 1.52 
                   
                   
                   
                   
                 0.13 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 11 
                 11523 
                 Cyclin- 
                   
                   
                   
                 0.15 
                   
                 0.06 
                 0.15 
                   
                   
                   
                   
                 2.40 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 12 
                 24358 
                 Cyclin- 
                   
                 0.76 
                   
                   
                   
                   
                 0.07 
                 0.04 
                   
                 0.24 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 13 
                 39125 
                 Cyclin- 
                   
                   
                   
                 0.23 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 14 
                 5362 
                 Cyclin- 
                   
                 0.68 
                   
                   
                   
                 0.06 
                   
                 0.08 
                   
                   
                   
                 1.17 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 15 
                 44857 
                 Cyclin- 
                   
                 0.68 
                   
                   
                   
                 0.06 
                   
                 0.08 
                   
                   
                   
                 1.17 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 16 
                 1743 
                 Cyclin A 
                   
                   
                 0.19 
                   
                 2.10 
                 0.06 
                 0.15 
               
               
                 17 
                 12405 
                 Cyclin A 
                   
                   
                   
                   
                   
                 0.06 
                 0.59 
                   
                   
                 2.84 
               
               
                 18 
                 3739 
                 Cyclin B 
                   
                 0.42 
                 1.99 
                 0.08 
                   
                   
                   
                   
                   
                   
                   
                 2.33 
               
               
                 19 
                 22338 
                 Cyclin B 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 0.86 
               
               
                 20 
                 28605 
                 Cyclin B 
                   
                   
                   
                   
                   
                 0.39 
                   
                 0.04 
                   
                 0.47 
               
               
                 21 
                 41006 
                 Cyclin B 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 0.71 
               
               
                 22 
                 6643 
                 Cyclin D 
                   
                 0.85 
                   
                   
                 0.83 
                 0.06 
                 1.06 
                 0.08 
                   
                   
                   
                 0.26 
               
               
                 23 
                 45338 
                 Cyclin D 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 2.03 
               
               
                 24 
                 46486 
                 Cyclin D 
                   
                   
                   
                   
                   
                   
                 0.30 
               
               
                 25 
                 12070 
                 Cyclin- 
                 0.24 
                   
                 0.82 
                   
                   
                 0.06 
                 0.26 
                   
                   
                   
                   
                 0.92 
               
               
                   
                   
                 dependent 
               
               
                   
                   
                 kinase 
               
               
                   
                   
                 regulatory 
               
               
                   
                   
                 subunit 
               
               
                 26 
                 6617 
                 Histone 
                   
                 0.08 
                   
                   
                   
                 0.06 
                 0.04 
                 0.55 
                   
                   
                 0.51 
                 0.26 
               
               
                   
                   
                 acetyltransferase 
               
               
                 27 
                 7827 
                 Histone 
                   
                   
                 2.27 
                   
                   
                 0.11 
                   
                 0.04 
               
               
                   
                   
                 acetyltransferase 
               
               
                 28 
                 8036 
                 Histone 
                   
                   
                   
                   
                 1.16 
               
               
                   
                   
                 acetyltransferase 
               
               
                 30 
                 1596 
                 Histone 
                   
                 0.17 
                 0.16 
                 0.08 
                 2.98 
                 0.88 
                 0.26 
                 0.98 
                   
                   
                   
                 0.71 
               
               
                   
                   
                 deacetylase 
               
               
                 31 
                 5870 
                 Histone 
                   
                   
                 0.19 
                   
                 0.17 
                   
                   
                 0.12 
                   
                   
                   
                 5.43 
               
               
                   
                   
                 deacetylase 
               
               
                 32 
                 6901 
                 Histone 
                 1.21 
                 0.08 
                   
                   
                   
                 2.01 
                 1.16 
                 0.08 
               
               
                   
                   
                 deacetylase 
               
               
                 33 
                 6902 
                 Histone 
                   
                 0.08 
                   
                   
                   
                 0.11 
                 1.21 
                   
                   
                   
                   
                 0.47 
               
               
                   
                   
                 deacetylase 
               
               
                 34 
                 7440 
                 Histone 
                 0.48 
                   
                 1.23 
                 0.15 
                   
                 0.22 
                 0.48 
                 0.20 
                   
                   
                   
                 2.02 
               
               
                   
                   
                 deacetylase 
               
               
                 35 
                 8994 
                 Histone 
                   
                   
                 0.09 
                   
                   
                   
                 0.15 
               
               
                   
                   
                 deacetylase 
               
               
                 36 
                 24580 
                 Histone 
                   
                 0.42 
                   
                   
                   
                   
                 1.22 
               
               
                   
                   
                 deacetylase 
               
               
                 37 
                 37831 
                 Histone 
                   
                 0.08 
                   
                   
                   
                 0.22 
                   
                 0.40 
                   
                 1.19 
                   
                 0.12 
               
               
                   
                   
                 deacetylase 
               
               
                 38 
                 34958 
                 MAT1 CDK- 
                   
                   
                   
                   
                   
                   
                 0.15 
                 0.23 
               
               
                   
                   
                 activating 
               
               
                   
                   
                 kinase 
               
               
                   
                   
                 assembly 
               
               
                   
                   
                 factor 
               
               
                 39 
                 22967 
                 Peptidyl- 
                   
                   
                 0.72 
                   
                   
                   
                   
                   
                   
                   
                   
                 0.69 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 40 
                 8599 
                 Peptidyl- 
                   
                   
                 0.46 
                 0.08 
                 0.50 
                 0.17 
                 0.51 
                 0.28 
                   
                   
                   
                 3.01 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 41 
                 9919 
                 Peptidyl- 
                   
                   
                 0.51 
                   
                 0.35 
                 0.06 
                 0.15 
                 0.43 
                   
                   
                   
                 4.24 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 42 
                 15820 
                 Peptidyl- 
                   
                   
                   
                   
                   
                   
                 0.04 
                   
                   
                   
                   
                 6.78 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 43 
                 8327 
                 Peptidyl- 
                   
                   
                   
                   
                   
                 0.06 
                   
                 0.04 
                   
                   
                   
                 6.86 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 44 
                 4604 
                 Peptidyl- 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 0.68 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 45 
                 966 
                 Peptidyl- 
                   
                 0.59 
                 1.02 
                 0.54 
                 0.69 
                 0.50 
                 0.93 
                 0.59 
                   
                 0.95 
                   
                 18.65 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 46 
                 1037 
                 Peptidyl- 
                   
                 0.59 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 47 
                 4603 
                 Peptidyl- 
                   
                 0.17 
                   
                   
                   
                 0.17 
                 1.24 
                 0.04 
                   
                   
                   
                 0.34 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 48 
                 5465 
                 Peptidyl- 
                   
                   
                 1.21 
                 0.08 
                 0.66 
                 0.11 
                 0.29 
                 0.16 
                   
                   
                   
                 6.99 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 49 
                 6571 
                 Peptidyl- 
                   
                 0.51 
                   
                 0.08 
                   
                   
                 0.41 
                 0.08 
                   
                   
                   
                 1.14 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 50 
                 6786 
                 Peptidyl- 
                   
                 0.42 
                   
                   
                   
                 0.33 
                 0.06 
                 0.41 
                 0.04 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 51 
                 7057 
                 Peptidyl- 
                   
                 0.42 
                   
                   
                   
                 0.11 
                 0.04 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 52 
                 8670 
                 Peptidyl- 
                   
                   
                 1.56 
                   
                   
                 0.39 
                   
                 0.20 
                   
                   
                   
                 0.12 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 53 
                 9137 
                 Peptidyl- 
                   
                   
                   
                   
                   
                   
                 0.04 
                 0.59 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 54 
                 10285 
                 Peptidyl- 
                   
                   
                   
                   
                 0.60 
                 1.16 
                 0.04 
                 0.04 
                   
                   
                   
                 0.45 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 55 
                 10600 
                 Peptidyl- 
                   
                   
                 0.16 
                   
                 0.17 
                 0.06 
                   
                   
                   
                   
                   
                 0.46 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 56 
                 11551 
                 Peptidyl- 
                   
                   
                   
                 0.08 
                   
                 0.06 
                 0.04 
                 0.08 
                   
                   
                   
                 1.89 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 57 
                 20743 
                 Peptidyl- 
                   
                   
                   
                   
                   
                   
                   
                 0.76 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 58 
                 23739 
                 Peptidyl- 
                   
                 0.59 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 60 
                 31985 
                 Peptidyl- 
                   
                   
                   
                   
                 1.99 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 61 
                 32025 
                 Peptidyl- 
                   
                   
                   
                   
                 0.99 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 62 
                 32173 
                 Peptidyl- 
                   
                   
                   
                   
                 1.99 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 64 
                 9143 
                 Retinoblastoma 
                   
                   
                 0.90 
                   
                   
                   
                 0.15 
               
               
                   
                   
                 related 
               
               
                   
                   
                 protein 
               
               
                 65 
                 349 
                 WD40 repeat 
                 0.24 
                   
                 0.34 
                 0.08 
                 0.17 
                 0.22 
                 0.33 
                 0.08 
                   
                   
                 0.25 
                 2.24 
               
               
                   
                   
                 protein 
               
               
                 66 
                 575 
                 WD40 repeat 
                   
                 0.25 
                 0.94 
                 0.31 
                 0.34 
                 0.11 
                   
                 0.16 
                   
                 0.47 
                   
                 1.87 
               
               
                   
                   
                 protein 
               
               
                 67 
                 804 
                 WD40 repeat 
                   
                   
                   
                 0.15 
                 0.34 
                 0.39 
                 0.33 
                 0.39 
                   
                   
                   
                 1.82 
               
               
                   
                   
                 protein 
               
               
                 68 
                 805 
                 WD40 repeat 
                 0.97 
                 0.51 
                 4.66 
                 0.23 
                 0.17 
                 0.77 
                 0.33 
                 1.07 
                   
                 0.24 
                   
                 4.43 
               
               
                   
                   
                 protein 
               
               
                 69 
                 806 
                 WD40 repeat 
                   
                   
                   
                   
                 0.83 
                   
                   
                 0.04 
               
               
                   
                   
                 protein 
               
               
                 70 
                 2248 
                 WD40 repeat 
                   
                 0.08 
                   
                 0.08 
                 1.92 
                 0.06 
                   
                 0.08 
                   
                   
                   
                 0.91 
               
               
                   
                   
                 protein 
               
               
                 71 
                 3203 
                 WD40 repeat 
                   
                 0.34 
                 0.18 
                 0.15 
                 0.17 
                 0.11 
                 0.30 
                 0.04 
                   
                   
                   
                 0.72 
               
               
                   
                   
                 protein 
               
               
                 72 
                 3209 
                 WD40 repeat 
                   
                 0.08 
                   
                 0.15 
                 0.17 
                   
                   
                 0.12 
                   
                   
                   
                 0.61 
               
               
                   
                   
                 protein 
               
               
                 73 
                 4429 
                 WD40 repeat 
                   
                 0.08 
                 1.16 
                 0.08 
                   
                   
                   
                   
                   
                   
                   
                 0.13 
               
               
                   
                   
                 protein 
               
               
                 74 
                 4607 
                 WD40 repeat 
                   
                 0.76 
                   
                 0.54 
                   
                 0.06 
                 0.07 
               
               
                   
                   
                 protein 
               
               
                 75 
                 4682 
                 WD40 repeat 
                   
                 0.08 
                 0.28 
                 0.23 
                   
                   
                 1.13 
                 0.08 
                   
                   
                   
                 0.12 
               
               
                   
                   
                 protein 
               
               
                 76 
                 5786 
                 WD40 repeat 
                   
                 0.08 
                   
                   
                   
                 0.06 
                 0.46 
                 0.08 
                   
                   
                   
                 0.13 
               
               
                   
                   
                 protein 
               
               
                 77 
                 5887 
                 WD40 repeat 
                   
                 1.61 
                 1.23 
                 0.08 
                   
                 0.06 
                 0.15 
                 0.28 
                   
                   
                   
                 1.41 
               
               
                   
                   
                 protein 
               
               
                 78 
                 5981 
                 WD40 repeat 
                   
                 0.08 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 0.37 
               
               
                   
                   
                 protein 
               
               
                 79 
                 6766 
                 WD40 repeat 
                 0.24 
                 0.08 
                 1.31 
                   
                 0.51 
                 0.06 
                 0.74 
                 0.51 
                   
                   
                   
                 0.28 
               
               
                   
                   
                 protein 
               
               
                 80 
                 6769 
                 WD40 repeat 
                   
                 0.93 
                   
                   
                 0.17 
                   
                   
                 0.12 
                   
                   
                   
                 2.28 
               
               
                   
                   
                 protein 
               
               
                 81 
                 6907 
                 WD40 repeat 
                   
                 0.25 
                   
                   
                 0.17 
                 0.06 
                 0.45 
                 0.32 
                   
                 0.47 
                   
                 1.67 
               
               
                   
                   
                 protein 
               
               
                 82 
                 7518 
                 WD40 repeat 
                   
                   
                 0.91 
                   
                   
                 0.28 
                 0.15 
                 0.55 
                   
                   
                   
                 0.59 
               
               
                   
                   
                 protein 
               
               
                 83 
                 7717 
                 WD40 repeat 
                   
                   
                 0.47 
                   
                   
                   
                   
                   
                   
                   
                   
                 0.38 
               
               
                   
                   
                 protein 
               
               
                 84 
                 7718 
                 WD40 repeat 
                 0.24 
                   
                 1.88 
                 0.08 
                   
                 0.22 
                   
                 0.04 
                   
                   
                   
                 0.92 
               
               
                   
                   
                 protein 
               
               
                 85 
                 7741 
                 WD40 repeat 
                   
                   
                 1.42 
                   
                   
                 0.11 
                   
                   
                   
                 0.47 
               
               
                   
                   
                 protein 
               
               
                 86 
                 7884 
                 WD40 repeat 
                   
                   
                 1.33 
                 0.15 
                   
                   
                   
                   
                   
                 0.24 
               
               
                   
                   
                 protein 
               
               
                 87 
                 8258 
                 WD40 repeat 
                 0.72 
                   
                 0.19 
                 0.23 
                 0.87 
                   
                 0.15 
                 0.08 
                   
                   
                   
                 0.08 
               
               
                   
                   
                 protein 
               
               
                 88 
                 8465 
                 WD40 repeat 
                   
                   
                 0.47 
                 0.08 
                 1.75 
               
               
                   
                   
                 protein 
               
               
                 89 
                 8616 
                 WD40 repeat 
                   
                   
                 0.57 
                 0.08 
                 0.69 
                   
                   
                 0.16 
                   
                   
                   
                 0.13 
               
               
                   
                   
                 protein 
               
               
                 90 
                 8690 
                 WD40 repeat 
                   
                   
                 0.26 
                 0.08 
                 0.35 
                 1.39 
                 0.34 
                 0.32 
                   
                 2.13 
                   
                 0.80 
               
               
                   
                   
                 protein 
               
               
                 91 
                 8708 
                 WD40 repeat 
                   
                   
                 0.57 
                   
                   
                   
                   
                 0.04 
               
               
                   
                   
                 protein 
               
               
                 92 
                 8850 
                 WD40 repeat 
                   
                   
                 0.09 
                   
                   
                 0.06 
                   
                 0.27 
                   
                   
                   
                 2.03 
               
               
                   
                   
                 protein 
               
               
                 93 
                 9072 
                 WD40 repeat 
                   
                   
                 1.21 
                   
                 0.17 
                   
                   
                   
                   
                   
                   
                 0.48 
               
               
                   
                   
                 protein 
               
               
                 94 
                 9465 
                 WD40 repeat 
                 0.24 
                   
                 0.72 
                   
                 0.33 
                   
                 0.15 
               
               
                   
                   
                 protein 
               
               
                 95 
                 9472 
                 WD40 repeat 
                   
                   
                 0.36 
                   
                 1.99 
                 0.11 
                 0.61 
                   
                   
                   
                   
                 6.90 
               
               
                   
                   
                 protein 
               
               
                 96 
                 9550 
                 WD40 repeat 
                   
                   
                 0.90 
                   
                   
                 0.11 
                 1.78 
               
               
                   
                   
                 protein 
               
               
                 97 
                 10284 
                 WD40 repeat 
                 0.24 
                 0.08 
                   
                   
                 1.82 
                   
                 1.22 
                 0.16 
                   
                 0.47 
                   
                 0.28 
               
               
                   
                   
                 protein 
               
               
                 98 
                 10595 
                 WD40 repeat 
                   
                   
                 0.16 
                   
                 0.17 
                 0.11 
                 6.52 
                   
                   
                   
                   
                 0.85 
               
               
                   
                   
                 protein 
               
               
                 99 
                 10657 
                 WD40 repeat 
                   
                   
                   
                   
                   
                 0.06 
                   
                 0.12 
               
               
                   
                   
                 protein 
               
               
                 100 
                 12636 
                 WD40 repeat 
                   
                   
                   
                   
                   
                 0.06 
                   
                   
                   
                   
                   
                 0.65 
               
               
                   
                   
                 protein 
               
               
                 101 
                 12748 
                 WD40 repeat 
                   
                   
                 1.50 
                 0.08 
                   
                 0.06 
                 1.67 
                 0.04 
                   
                   
                   
                 0.38 
               
               
                   
                   
                 protein 
               
               
                 102 
                 12879 
                 WD40 repeat 
                   
                   
                   
                 0.08 
                 0.33 
                 0.06 
                 0.04 
                 0.08 
                   
                   
                   
                 2.00 
               
               
                   
                   
                 protein 
               
               
                 103 
                 15515 
                 WD40 repeat 
                   
                   
                   
                   
                 0.35 
                   
                 0.30 
               
               
                   
                   
                 protein 
               
               
                 104 
                 15724 
                 WD40 repeat 
                   
                 0.25 
                 0.33 
                 0.15 
                   
                   
                 0.47 
                 0.04 
                   
                   
                   
                 0.39 
               
               
                   
                   
                 protein 
               
               
                 105 
                 16167 
                 WD40 repeat 
                 0.24 
                   
                   
                   
                 0.52 
               
               
                   
                   
                 protein 
               
               
                 106 
                 16633 
                 WD40 repeat 
                   
                   
                 1.96 
                   
                   
                   
                   
                 0.12 
                   
                   
                   
                 0.42 
               
               
                   
                   
                 protein 
               
               
                 107 
                 17485 
                 WD40 repeat 
                   
                   
                 0.65 
               
               
                   
                   
                 protein 
               
               
                 108 
                 18007 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                   
                 0.12 
               
               
                   
                   
                 protein 
               
               
                 109 
                 20775 
                 WD40 repeat 
                   
                   
                   
                   
                 0.17 
                   
                   
                 0.08 
               
               
                   
                   
                 protein 
               
               
                 110 
                 23132 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 2.42 
               
               
                   
                   
                 protein 
               
               
                 111 
                 23569 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                 0.91 
                   
                   
                   
                   
                 0.91 
               
               
                   
                   
                 protein 
               
               
                 112 
                 23611 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                 4.15 
               
               
                   
                   
                 protein 
               
               
                 113 
                 24934 
                 WD40 repeat 
                   
                 0.34 
                   
                   
                   
                   
                   
                 0.04 
               
               
                   
                   
                 protein 
               
               
                 114 
                 25546 
                 WD40 repeat 
                   
                   
                 0.09 
               
               
                   
                   
                 protein 
               
               
                 115 
                 30134 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                 0.07 
               
               
                   
                   
                 protein 
               
               
                 116 
                 31787 
                 WD40 repeat 
                   
                   
                 0.19 
                   
                   
                   
                   
                   
                   
                   
                   
                 1.19 
               
               
                   
                   
                 protein 
               
               
                 117 
                 34435 
                 WD40 repeat 
                   
                   
                   
                   
                 0.35 
                   
                   
                 0.08 
               
               
                   
                   
                 protein 
               
               
                 118 
                 34452 
                 WD40 repeat 
                   
                   
                 1.44 
                   
                   
                   
                   
                 0.20 
                   
                   
                   
                 0.25 
               
               
                   
                   
                 protein 
               
               
                 119 
                 35789 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                   
                 0.20 
               
               
                   
                   
                 protein 
               
               
                 120 
                 35804 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                 0.19 
                 0.27 
                   
                   
                   
                 0.08 
               
               
                   
                   
                 protein 
               
               
                 121 
                 43057 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                 0.30 
                   
                   
                   
                   
                 0.57 
               
               
                   
                   
                 protein 
               
               
                 122 
                 46741 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                 0.46 
               
               
                   
                   
                 protein 
               
               
                 123 
                 47161 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                 1.78 
               
               
                   
                   
                 protein 
               
               
                 235 
                 6366 
                 WD40 repeat 
                   
                 0.08 
                 0.68 
                 0.23 
                 0.93 
                 0.11 
                 0.36 
                 0.83 
                   
                 0.24 
                   
                 0.94 
               
               
                   
                   
                 protein 
               
               
                 236 
                 17378 
                 WD40 repeat 
                   
                   
                 0.65 
                   
                   
                   
                   
                 0.12 
                   
                   
                   
                 0.08 
               
               
                   
                   
                 protein 
               
               
                 252 
                 45414 
                 Cyclin B 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 3.13 
               
               
                 253 
                 44328 
                 Cyclin- 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 0.38 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 kinase 
               
               
                   
                   
                 inhibitor 
               
               
                 254 
                 15615 
                 Histone 
                   
                   
                   
                   
                   
                   
                 0.22 
                 0.04 
               
               
                   
                   
                 acetyltransferase 
               
               
                 255 
                 17239 
                 Peptidyl- 
                   
                   
                   
                 0.08 
                 0.50 
                   
                   
                 0.08 
               
               
                   
                   
                 prolyl cis- 
               
               
                   
                   
                 trans 
               
               
                   
                   
                 isomerase 
               
               
                 256 
                 18643 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                   
                 0.04 
                   
                   
                   
                 0.90 
               
               
                   
                   
                 protein 
               
               
                 257 
                 19127 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                   
                 0.04 
                   
                   
                   
                 0.89 
               
               
                   
                   
                 protein 
               
               
                 258 
                 22624 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 1.16 
               
               
                   
                   
                 protein 
               
               
                 259 
                 32424 
                 WD40 repeat 
                   
                   
                   
                   
                 0.50 
               
               
                   
                   
                 protein 
               
               
                 260 
                 37472 
                 WD40 repeat 
                   
                   
                   
                   
                   
                   
                   
                 0.08 
                   
                   
                   
                 0.17 
               
               
                   
                   
                 protein 
               
               
                   
               
               
                 In Table 12, the following numbers 1-12 represent the following tissues: 
               
               
                 1 is bud reproductive; 
               
               
                 2 is bud vegetative; 
               
               
                 3 is cambium; 
               
               
                 4 is fruit; 
               
               
                 5 is leaf 6 is phloem; 
               
               
                 7 is reproductive; 
               
               
                 8 is root; 
               
               
                 9 is sap vegetative; 
               
               
                 10 is stem; 
               
               
                 11 is whole; and 
               
               
                 12 is xylem. 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 13 
               
             
            
               
                   
               
               
                 Pine in silico data. 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 ConsID 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 SEQ 
                 
                   pinus 
                 
               
               
                 ID 
                 
                   Radiata 
                 
                 Family 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 8 
                 9 
                 10 
                 11 
                 12 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 124 
                 1766 
                 Cyclin- 
                   
                   
                   
                 1.02 
                 0.05 
                 1.58 
                 0.15 
                 0.22 
                 0.22 
                 0.18 
                 2.16 
                 4.91 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 125 
                 2927 
                 Cyclin- 
                 0.16 
                   
                   
                   
                   
                 0.19 
                 0.11 
                 0.14 
                 0.04 
                 0.36 
                 0.38 
                 0.17 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 126 
                 7642 
                 Cyclin- 
                   
                   
                 0.22 
                 0.21 
                 0.05 
                   
                   
                   
                 0.07 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 127 
                 13714 
                 Cyclin- 
                   
                   
                   
                   
                   
                 0.11 
                 0.11 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 128 
                 16332 
                 Cyclin- 
                   
                   
                   
                   
                   
                 0.54 
                 0.26 
                   
                 0.14 
                   
                 0.04 
                 0.91 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 129 
                 21677 
                 Cyclin- 
                   
                   
                   
                   
                 0.05 
                 0.14 
                   
                   
                   
                   
                   
                 0.17 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 130 
                 27562 
                 Cyclin- 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 0.41 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 131 
                 1504 
                 Cyclin- 
                 0.16 
                   
                   
                   
                   
                 0.36 
                   
                 0.35 
                 0.21 
                 0.54 
                 0.09 
                 0.65 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 132 
                 15211 
                 Cyclin- 
                   
                   
                   
                   
                   
                 0.13 
                 0.15 
                   
                   
                   
                 0.19 
                 0.19 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 133 
                 20421 
                 Cyclin- 
                   
                   
                   
                   
                   
                   
                   
                   
                 0.04 
                   
                 0.05 
                 0.95 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 134 
                 3187 
                 Cyclin- 
                   
                   
                   
                   
                   
                 0.34 
                 0.15 
                   
                 0.04 
                 0.18 
                 0.38 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 135 
                 15661 
                 Cyclin- 
                   
                   
                   
                   
                   
                   
                   
                   
                 0.04 
                   
                 0.13 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 136 
                 13874 
                 Cyclin A 
                 0.31 
                   
                   
                   
                   
                 0.27 
                 0.15 
                   
                   
                   
                 0.05 
               
               
                 137 
                 14615 
                 Cyclin A 
                 0.16 
                   
                   
                   
                   
                 0.15 
               
               
                 138 
                 4578 
                 Cyclin B 
                 0.47 
                 0.14 
                   
                   
                   
                 0.13 
                 0.22 
                   
                   
                   
                 0.74 
                 0.38 
               
               
                 139 
                 23387 
                 Cyclin B 
                   
                   
                   
                   
                   
                 0.29 
                 0.26 
                   
                   
                   
                   
                 0.17 
               
               
                 140 
                 6970 
                 Cyclin D 
                   
                 0.14 
                   
                   
                   
                   
                   
                 0.27 
                 0.04 
               
               
                 141 
                 10322 
                 Cyclin D 
                 0.16 
                   
                   
                 0.19 
                   
                 0.06 
                   
                   
                 0.14 
                   
                 1.12 
                 1.36 
               
               
                 142 
                 22721 
                 Cyclin D 
                   
                   
                   
                   
                   
                 0.27 
                   
                 0.36 
               
               
                 143 
                 23407 
                 Cyclin D 
                   
                   
                   
                   
                   
                 0.15 
                 0.26 
                   
                   
                   
                   
                 0.31 
               
               
                 144 
                 1945 
                 Cyclin- 
                   
                 0.28 
                 0.55 
                 0.41 
                 0.16 
                 1.62 
                 5.02 
                 0.22 
                 0.72 
                   
                 0.39 
                 3.06 
               
               
                   
                   
                 dependent 
               
               
                   
                   
                 kinase 
               
               
                   
                   
                 regulatory 
               
               
                   
                   
                 subunit 
               
               
                 145 
                 8233 
                 Cyclin- 
                   
                   
                   
                 0.21 
               
               
                   
                   
                 dependent 
               
               
                   
                   
                 kinase 
               
               
                   
                   
                 regulatory 
               
               
                   
                   
                 subunit 
               
               
                 146 
                 8234 
                 Cyclin- 
                 0.16 
                   
                 0.11 
               
               
                   
                   
                 dependent 
               
               
                   
                   
                 kinase 
               
               
                   
                   
                 regulatory 
               
               
                   
                   
                 subunit 
               
               
                 147 
                 22054 
                 Cyclin- 
                   
                   
                   
                   
                 0.05 
                   
                 0.22 
                   
                   
                   
                 0.18 
               
               
                   
                   
                 dependent 
               
               
                   
                   
                 kinase 
               
               
                   
                   
                 regulatory 
               
               
                   
                   
                 subunit 
               
               
                 148 
                 12137 
                 Histone 
                   
                   
                   
                   
                   
                 0.06 
                   
                   
                   
                   
                 1.51 
                 0.19 
               
               
                   
                   
                 acetyltransferase 
               
               
                 149 
                 12582 
                 Histone 
                   
                   
                   
                   
                   
                 0.64 
                 0.15 
                 1.09 
                   
                   
                 0.33 
                 0.63 
               
               
                   
                   
                 acetyltransferase 
               
               
                 150 
                 15285 
                 Histone 
                   
                   
                   
                 0.21 
                   
                   
                   
                   
                 0.12 
                   
                 0.70 
                 0.14 
               
               
                   
                   
                 acetyltransferase 
               
               
                 151 
                 17229 
                 Histone 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 0.94 
                 0.16 
               
               
                   
                   
                 acetyltransferase 
               
               
                 152 
                 20724 
                 Histone 
                   
                   
                   
                   
                   
                   
                   
                   
                 0.04 
                   
                 0.19 
                 0.19 
               
               
                   
                   
                 acetyltransferase 
               
               
                 153 
                 4555 
                 Histone 
                 0.16 
                 0.14 
                   
                   
                   
                 0.97 
                   
                 0.14 
                   
                   
                 0.89 
                 0.89 
               
               
                   
                   
                 deacetylase 
               
               
                 154 
                 4556 
                 Histone 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 0.14 
               
               
                   
                   
                 deacetylase 
               
               
                 155 
                 5729 
                 Histone 
                 0.31 
                 0.28 
                 0.22 
                 0.58 
                 0.22 
                 2.00 
                 0.48 
                 0.07 
                 0.04 
                   
                 2.73 
                 1.46 
               
               
                   
                   
                 deacetylase 
               
               
                 156 
                 7395 
                 Histone 
                   
                 0.14 
                   
                 0.14 
                   
                   
                 0.19 
                 0.93 
                 0.04 
                   
                 0.14 
                 1.33 
               
               
                   
                   
                 deacetylase 
               
               
                 157 
                 9503 
                 Histone 
                   
                   
                 0.11 
                   
                   
                   
                   
                 0.14 
               
               
                   
                   
                 deacetylase 
               
               
                 158 
                 11283 
                 Histone 
                   
                   
                   
                 0.19 
                   
                   
                 0.15 
                   
                   
                   
                 0.96 
                 1.35 
               
               
                   
                   
                 deacetylase 
               
               
                 159 
                 12322 
                 Histone 
                 0.16 
                   
                   
                   
                   
                 0.06 
                 0.11 
                   
                 0.04 
                   
                 0.05 
                 0.29 
               
               
                   
                   
                 deacetylase 
               
               
                 161 
                 23236 
                 Histone 
                   
                   
                   
                   
                   
                 0.13 
                   
                   
                 0.11 
               
               
                   
                   
                 deacetylase 
               
               
                 162 
                 171 
                 Peptidyl- 
                   
                   
                   
                   
                   
                   
                   
                   
                 0.07 
                   
                   
                 0.46 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 163 
                 172 
                 Peptidyl- 
                   
                   
                   
                   
                   
                 0.19 
                   
                   
                 0.11 
                 0.18 
                 0.11 
                 0.46 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 164 
                 1480 
                 Peptidyl- 
                 2.51 
                 4.20 
                 0.88 
                 2.97 
                 1.58 
                 3.53 
                 7.36 
                 1.33 
                 2.74 
                 0.72 
                 6.62 
                 10.14 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 168 
                 1692 
                 Peptidyl- 
                 0.16 
                   
                 0.22 
                   
                 0.65 
                 0.61 
                 0.26 
                   
                 0.29 
                 0.18 
                 1.28 
                 0.34 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 169 
                 5313 
                 Peptidyl- 
                   
                 0.14 
                   
                   
                   
                   
                   
                 0.07 
                   
                   
                 0.37 
                 0.17 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 170 
                 6362 
                 Peptidyl- 
                   
                 0.14 
                 0.33 
                 0.05 
                   
                 0.06 
                 0.60 
                   
                 0.04 
                   
                 2.92 
                 0.68 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 171 
                 6493 
                 Peptidyl- 
                   
                 0.42 
                 0.11 
                 0.21 
                   
                   
                 0.11 
                   
                 0.04 
                   
                 0.25 
                 0.32 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 172 
                 6983 
                 Peptidyl- 
                   
                   
                   
                 0.61 
                   
                 0.13 
                   
                   
                   
                   
                 0.04 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 174 
                 7665 
                 Peptidyl- 
                   
                   
                 0.11 
                 0.39 
                 0.05 
                 0.62 
                   
                   
                   
                   
                 0.25 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 175 
                 12196 
                 Peptidyl- 
                   
                   
                   
                   
                   
                 0.19 
                 0.15 
                 0.14 
                 0.16 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 176 
                 13382 
                 Peptidyl- 
                   
                   
                   
                 0.25 
                   
                 0.06 
                   
                 0.07 
                 0.04 
                   
                 0.87 
                 0.15 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 177 
                 16461 
                 Peptidyl- 
                   
                   
                   
                 0.19 
                   
                 0.15 
                 0.15 
                   
                 0.04 
                   
                 0.04 
                 0.74 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 178 
                 17611 
                 Peptidyl- 
                   
                   
                   
                 0.24 
                 0.11 
                 0.27 
                 0.41 
                   
                   
                   
                 0.99 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 179 
                 19776 
                 Peptidyl- 
                   
                   
                   
                   
                   
                 0.13 
                   
                 0.07 
                 0.16 
                   
                 0.05 
                 0.61 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 180 
                 20659 
                 Peptidyl- 
                   
                   
                   
                   
                   
                   
                   
                 0.15 
                   
                   
                 0.19 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 181 
                 22559 
                 Peptidyl- 
                   
                   
                   
                   
                   
                   
                 0.11 
                 0.14 
                   
                   
                   
                 0.20 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 182 
                 24188 
                 Peptidyl- 
                   
                   
                   
                   
                   
                   
                   
                   
                 0.23 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 183 
                 27973 
                 Peptidyl- 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 1.01 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 184 
                 1353 
                 WD40 
                   
                   
                 0.44 
                   
                 0.05 
                 0.73 
                   
                   
                 0.11 
                 1.07 
                 0.70 
                 1.32 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 185 
                 1978 
                 WD40 
                   
                 0.14 
                   
                 0.05 
                   
                 0.44 
                 0.11 
                 0.21 
                 0.27 
                 0.36 
                 1.46 
                 0.82 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 186 
                 2810 
                 WD40 
                   
                 0.42 
                   
                 0.79 
                 0.11 
                 0.39 
                   
                 0.27 
                   
                 0.36 
                 1.69 
                 1.03 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 187 
                 2811 
                 WD40 
                   
                   
                   
                   
                   
                   
                   
                   
                 0.14 
                   
                 0.09 
                 0.14 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 188 
                 2812 
                 WD40 
                   
                   
                   
                   
                   
                   
                 0.15 
                   
                   
                 0.18 
                 0.04 
                 0.16 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 189 
                 3514 
                 WD40 
                   
                   
                   
                 0.63 
                   
                 0.06 
                   
                 0.14 
                   
                 0.18 
                 0.48 
                 0.56 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 190 
                 4104 
                 WD40 
                   
                 0.14 
                   
                 0.25 
                   
                 0.27 
                 0.37 
                 0.36 
                 0.19 
                 0.18 
                 0.39 
                 0.53 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 191 
                 5595 
                 WD40 
                   
                 0.14 
                   
                 0.25 
                   
                   
                 0.15 
                 0.14 
                 0.07 
                   
                 0.23 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 192 
                 5754 
                 WD40 
                 0.31 
                 0.14 
                   
                   
                   
                 0.06 
                   
                 0.07 
                 0.16 
                   
                 0.10 
                 0.16 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 193 
                 6463 
                 WD40 
                 0.16 
                 0.56 
                 0.22 
                 0.43 
                   
                 0.81 
                 0.53 
                 0.21 
                 0.08 
                   
                 1.00 
                 0.70 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 194 
                 6665 
                 WD40 
                 0.31 
                 0.28 
                   
                 0.45 
                 0.44 
                 0.96 
                   
                   
                 0.07 
                   
                 3.37 
                 2.68 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 195 
                 6750 
                 WD40 
                   
                 0.14 
                   
                 0.59 
                 0.05 
                   
                 0.37 
                 0.42 
                 0.04 
                   
                 0.18 
                 0.52 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 196 
                 7030 
                 WD40 
                 0.31 
                   
                   
                 0.40 
                 0.54 
                 0.45 
                 0.37 
                   
                 0.07 
                   
                 1.58 
                 3.41 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 197 
                 7854 
                 WD40 
                   
                   
                 0.11 
                   
                   
                   
                   
                 0.14 
                   
                   
                 0.05 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 198 
                 7917 
                 WD40 
                   
                   
                 0.22 
                 0.39 
                   
                 0.13 
                 0.15 
                   
                   
                   
                 0.18 
                 0.56 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 199 
                 7989 
                 WD40 
                   
                   
                 0.11 
                   
                   
                   
                   
                   
                 0.04 
                   
                 0.11 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 200 
                 8506 
                 WD40 
                 0.47 
                   
                 0.33 
                   
                 0.11 
                 0.86 
                 0.19 
                 1.28 
                 0.04 
                   
                 1.23 
                 3.12 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 201 
                 8692 
                 WD40 
                   
                   
                   
                 0.21 
                   
                 0.06 
                 0.11 
                   
                 0.15 
                   
                 0.10 
                 0.87 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 202 
                 8693 
                 WD40 
                   
                   
                 0.11 
                 0.80 
                   
                 0.25 
                   
                 0.14 
                 0.18 
                   
                 0.53 
                 0.31 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 203 
                 9170 
                 WD40 
                 0.16 
                   
                 0.11 
                 0.05 
                   
                   
                   
                   
                   
                   
                 0.05 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 204 
                 9408 
                 WD40 
                   
                   
                 0.33 
                   
                 0.05 
                 0.41 
                 0.15 
                 0.14 
                   
                   
                 0.41 
                 0.33 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 205 
                 9522 
                 WD40 
                   
                   
                 0.11 
                   
                   
                   
                   
                   
                   
                   
                 0.18 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 206 
                 9734 
                 WD40 
                   
                   
                 0.11 
                 0.05 
                 0.11 
                 0.15 
                   
                 0.07 
                 0.25 
                   
                 0.11 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 207 
                 9815 
                 WD40 
                   
                   
                 0.11 
                   
                   
                   
                   
                   
                   
                   
                 0.18 
                 0.14 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 208 
                 10670 
                 WD40 
                   
                   
                   
                 0.40 
                 0.16 
                 0.11 
                   
                   
                 0.16 
                   
                 0.34 
                 0.31 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 209 
                 11297 
                 WD40 
                   
                   
                   
                 0.53 
                   
                   
                 0.15 
                   
                 0.16 
                   
                 0.05 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 210 
                 13098 
                 WD40 
                   
                   
                   
                 0.19 
                 0.11 
                 0.54 
                 0.31 
                 0.14 
                 0.26 
                   
                 1.85 
                 0.14 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 211 
                 13172 
                 WD40 
                   
                   
                   
                   
                   
                   
                   
                   
                 0.04 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 212 
                 13589 
                 WD40 
                   
                   
                   
                   
                 0.11 
                 0.06 
                   
                 0.21 
                   
                   
                 0.05 
                 0.37 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 213 
                 13608 
                 WD40 
                   
                   
                   
                   
                   
                 0.11 
                   
                   
                 0.04 
                   
                 0.59 
                 0.33 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 214 
                 14299 
                 WD40 
                 0.16 
                   
                   
                 0.05 
                   
                   
                   
                 1.09 
                   
                   
                 0.38 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 215 
                 14498 
                 WD40 
                   
                   
                   
                 0.21 
                   
                   
                   
                   
                   
                   
                 0.44 
                 0.30 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 216 
                 14548 
                 WD40 
                 0.16 
                   
                   
                   
                   
                   
                   
                   
                 0.11 
                   
                 0.11 
                 0.82 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 217 
                 14610 
                 WD40 
                 0.16 
                   
                   
                   
                   
                 0.27 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 218 
                 16090 
                 WD40 
                   
                   
                   
                   
                   
                 0.43 
                   
                   
                 0.04 
                   
                 0.37 
                 0.85 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 219 
                 16722 
                 WD40 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 0.10 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 220 
                 16785 
                 WD40 
                   
                   
                   
                 0.05 
                   
                 0.13 
                   
                   
                   
                   
                 0.38 
                 0.50 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 221 
                 17094 
                 WD40 
                   
                   
                   
                   
                   
                 0.29 
                 0.15 
                   
                   
                   
                 0.24 
                 0.81 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 222 
                 17527 
                 WD40 
                   
                   
                   
                   
                   
                   
                   
                   
                 0.04 
                   
                 0.10 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 223 
                 17591 
                 WD40 
                   
                   
                   
                   
                   
                 0.14 
                   
                   
                   
                   
                 0.10 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 224 
                 17769 
                 WD40 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 0.39 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 225 
                 18047 
                 WD40 
                   
                   
                   
                 0.05 
                 0.22 
                 0.98 
                 0.15 
                 2.68 
                 0.07 
                   
                 0.19 
                 0.80 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 226 
                 18414 
                 WD40 
                   
                   
                   
                   
                 0.16 
                 0.15 
                   
                   
                 0.34 
                   
                 0.23 
                 0.19 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 227 
                 18986 
                 WD40 
                   
                   
                   
                   
                   
                 0.41 
                   
                   
                   
                   
                 0.15 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 228 
                 19479 
                 WD40 
                   
                   
                   
                   
                 0.05 
                   
                   
                   
                   
                   
                 0.28 
                 0.32 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 229 
                 20144 
                 WD40 
                   
                   
                   
                 0.43 
                   
                   
                 0.29 
                   
                   
                   
                 0.05 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 230 
                 22480 
                 WD40 
                   
                   
                   
                   
                   
                   
                 0.15 
                 0.27 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 231 
                 23079 
                 WD40 
                   
                   
                   
                   
                   
                 0.13 
                   
                   
                 0.04 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 232 
                 26739 
                 WD40 
                   
                   
                   
                   
                   
                   
                 0.15 
                   
                   
                   
                 0.18 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 233 
                 26951 
                 WD40 
                   
                   
                   
                 0.21 
                   
                   
                   
                   
                   
                   
                   
                 0.20 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 234 
                 26529 
                 WEE1-like 
                   
                   
                   
                   
                   
                   
                   
                   
                 0.04 
                   
                 0.18 
               
               
                   
                   
                 protein 
               
               
                 237 
                 888 
                 WD40 
                   
                   
                   
                   
                   
                   
                 0.11 
                   
                   
                   
                 0.18 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 238 
                 14166 
                 Cyclin- 
                 0.16 
                   
                   
                 0.05 
                   
                   
                   
                   
                   
                   
                 0.05 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 kinase 
               
               
                   
                   
                 inhibitor 
               
               
                 239 
                 3189 
                 Cyclin- 
                   
                   
                   
                   
                   
                 0.06 
               
               
                   
                   
                 dependant 
               
               
                   
                   
                 protein 
               
               
                   
                   
                 kinase 
               
               
                 240 
                 9356 
                 Histone 
                   
                   
                 0.11 
                   
                   
                   
                 0.22 
                   
                   
                   
                   
                 0.46 
               
               
                   
                   
                 acetyltransferase 
               
               
                 241 
                 65 
                 Histone 
                 0.16 
                   
                   
                   
                 0.22 
                 0.27 
                 0.22 
                   
                   
                   
                 0.24 
                 0.34 
               
               
                   
                   
                 deacetylase 
               
               
                 242 
                 14197 
                 Histone 
                 0.16 
                   
                   
                   
                 0.33 
                   
                   
                   
                   
                   
                 0.05 
               
               
                   
                   
                 deacetylase 
               
               
                 243 
                 9081 
                 Peptidyl- 
                   
                   
                 0.11 
                   
                 0.05 
                   
                 0.29 
                   
                 0.26 
                   
                 0.69 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 244 
                 13417 
                 Peptidyl- 
                   
                   
                   
                   
                   
                 0.06 
                   
                   
                   
                   
                 0.59 
               
               
                   
                   
                 prolyl 
               
               
                   
                   
                 cis-trans 
               
               
                   
                   
                 isomerase 
               
               
                 245 
                 5755 
                 WD40 
                 0.16 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 246 
                 6670 
                 WD40 
                   
                 0.14 
                   
                 0.05 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 247 
                 7027 
                 WD40 
                   
                 0.14 
                   
                   
                   
                 0.15 
                   
                   
                   
                   
                 1.30 
                 0.15 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 248 
                 7276 
                 WD40 
                   
                 0.14 
                   
                   
                   
                   
                 0.11 
                   
                   
                   
                 0.05 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 249 
                 7390 
                 WD40 
                 0.31 
                 0.14 
                   
                   
                 0.11 
                   
                 0.44 
                   
                   
                   
                 1.29 
                 0.38 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 250 
                 12648 
                 WD40 
                   
                   
                   
                 0.05 
                   
                 0.06 
                   
                   
                   
                   
                 0.05 
                 0.94 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                 251 
                 13171 
                 WD40 
                   
                   
                   
                 0.19 
                   
                 0.63 
                   
                   
                   
                   
                 0.19 
                 0.34 
               
               
                   
                   
                 repeat 
               
               
                   
                   
                 protein 
               
               
                   
               
               
                 Table 13, the following numbers 1-12 represent the following tissues: 
               
               
                 1 is bud reproductive; 
               
               
                 2 is bud vegetative; 
               
               
                 3 is callus; 
               
               
                 4 is cambium; 
               
               
                 5 is meristem vegetative; 
               
               
                 6 is phloem; 
               
               
                 7 is reproductive female; 
               
               
                 8 is reproductive male; 
               
               
                 9 is root; 
               
               
                 10 is vascular; 
               
               
                 11 is whole; and 
               
               
                 12 is xylem. 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 14 
               
             
            
               
                   
               
               
                 Oligo Table. 
               
            
           
           
               
               
               
               
            
               
                 Oligo 
                   
                   
                   
               
               
                 SEQ 
               
               
                 ID 
                 Oligo ID 
                 Microarray Oligo Seq 
               
               
                   
               
               
                 521 
                 Euc_003910_O_4 
                 GATTTTAAGTAACTCAATTAGCAGTTCCAACATTAAACCATTATTATTACCCCTTTTATC 
                   
               
               
                   
               
               
                 522 
                 Euc_019213_O_1 
                 CTCAAAAAGTACTTGGATGCGTGCGGTGACAACGGACTCGAACCGTACACTGTCAAATCT 
               
               
                   
               
               
                 523 
                 Euc_036800_O_4 
                 TTGTCAAGTTGCAGGACGTAGTGCACAGTGAGAGGCGTCTATATCTAGTTTTTGAGTACT 
               
               
                   
               
               
                 524 
                 Euc_040260_O_1 
                 GAAGAAATTATATAACTAGATACAAGGTTAGCTAGGTATATAATAGCGGTACAAGTCTTT 
               
               
                   
               
               
                 525 
                 Euc_041965_O_1 
                 GGACAAATCAAGTAGAACTTCTCTCGGCAGCATCAGTTTTTCTAATCCATGCCTTGTTGC 
               
               
                   
               
               
                 526 
                 Euc_002906_O_1 
                 CTCAGTTCTGATAATGCCTCGGATATATGGCCGAGTGTTCGCTGGACGGCCTCTTATGTT 
               
               
                   
               
               
                 527 
                 Euc_001518_O_3 
                 GGAGATTCTGAACTGCAACAGCTCCTACACATTTTCAGACTGTTGGGTACTCCAAATGAA 
               
               
                   
               
               
                 528 
                 Euc_008078_O_2 
                 GACTGGTAAAATCGTTGCACTAAAAAAGGTCCGGTTTGACAACTTGGAACCTGAAAGCGT 
               
               
                   
               
               
                 529 
                 Euc_009826_O_4 
                 AAACACCAATCTATCAACACTGTCGAGTTTAGTCACTAGTAGAACCGGAGATAACAAACA 
               
               
                   
               
               
                 530 
                 Euc_010364_O_1 
                 CTATGATCCTGAGCGCAAGCAAGTTATGACCAATAGAGTCGTTACACTATGGTACCGAGC 
               
               
                   
               
               
                 531 
                 Euc_011523_O_1 
                 TGTTGTGAAGGTAGTTATAGCCATCGATTAGACAGTGATTAAAGTAGTACCCGTGCCAAT 
               
               
                   
               
               
                 532 
                 Euc_024358_O_2 
                 CCACATACAAGAGTTGTTACGCTACACATCCTATACCATCAAAGGAACGTTGGAATGCCA 
               
               
                   
               
               
                 533 
                 Euc_039125_O_3 
                 TATGATCGACACAAGCATTTTGTGTTGGAGCCTCAGCTAATTGTATGTCATCGAGTACTT 
               
               
                   
               
               
                 534 
                 Euc_005362_O_3 
                 AAAATTTTTGCTACGGATAATGTTGTGAGGCGAGGCAGTCGAAATTACGGAGGTTGACTT 
               
               
                   
               
               
                 535 
                 Euc_044857_O_1 
                 ATGCAGGGATCAAATTTGTGAGTACTACGTAAAATTTTGCTACGGAGGCGAGGCAGTCGA 
               
               
                   
               
               
                 536 
                 Euc_001743_O_1 
                 GAAGAATACAGGCTCGTACCTGATACACTGTACCTGACTGTTAACTACATAGATCGGTAT 
               
               
                   
               
               
                 537 
                 Euc_012405_O_1 
                 TCCACCCTAAATGCGATACGTGAAAAGTATAGACAACAGAAGGTAAACTATTCATTACTG 
               
               
                   
               
               
                 538 
                 Euc_003739_O_2 
                 AGGCTTCTAGTTGCGTTCCCCCAAACTACATGGATCGGCAGCAGGATATTAATGAGCGGA 
               
               
                   
               
               
                 539 
                 Euc_022338_O_2 
                 GAGAAAAATGACAGATTGATATCGATGATGATGACTGTCGTGTCATCAGTAGTGTGCTTT 
               
               
                   
               
               
                 540 
                 Euc_028605_O_5 
                 TTTCCAATTGTAGTTCGTCTTTTATTGTAACAATAAATTGATAGATACTGATTCGAAATA 
               
               
                   
               
               
                 541 
                 Euc_041006_O_1 
                 ACATTTATGCTAACTATAGGAGAACGGAGAATTGTAGCTGCGTCTCTGCTAACTACATGG 
               
               
                   
               
               
                 542 
                 Euc_006643_O_1 
                 TTCTGGCTTAAAGGCTATTCTTTGTGCACAATGACCTGAGGGAGGTCTCGACAGACCACT 
               
               
                   
               
               
                 543 
                 Euc_045338_O_1 
                 TTCATCCGGGTCCTGGTTATCATACTCTTATATATGTTGGGGAATAACGGTTCATATGTT 
               
               
                   
               
               
                 544 
                 Euc_046486_O_3 
                 GGGTGTGCTTAATAGTTCTTATTAGTCTTAGCTTATTATCTTTGATTGGACATGCTATAA 
               
               
                   
               
               
                 545 
                 Euc_012070_O_2 
                 CTTGCTAAGTAGACATGTTATATTTCTAATGCTTTGAGAACAATATTACAGTATAATTAG 
               
               
                   
               
               
                 546 
                 Euc_006617_O_2 
                 AATCATCGACTAGACCGATGGTCAAAGTGGTAATCATGTAATTAAACGCGTTTGTCATTG 
               
               
                   
               
               
                 547 
                 Euc_007827_O_2 
                 ATGGAAAAATCTATGGATATGAAGGATTGAAGATATCCGTCTGGGTAAGCTGTGTATCAT 
               
               
                   
               
               
                 548 
                 Euc_008036_O_3 
                 TTATGATTTGAGAAAACCCTTGCAGGCTGCGATTTGCGGATCATGACAGCATAGTTTTGC 
               
               
                   
               
               
                 549 
                 Euc_001596_O_2 
                 GTTTTGTTGTGAGGGCTTGGTAGGTTTTCATTATATTGTAATGTCGACGACAGAGATTTT 
               
               
                   
               
               
                 550 
                 Euc_005870_O_3 
                 CCAATTAATGTTACTGCTCAAGCTGACGTACCTGCGAAAAAAGCACCAGTGACTGCTAAT 
               
               
                   
               
               
                 551 
                 Euc_006901_O_3 
                 TGATGTCAAAACGTAGCTCTTTTTTGTGTGAGCTATCCTGCTAAATTAAACCTCAGCAAA 
               
               
                   
               
               
                 552 
                 Euc_006902_O_1 
                 ACATGAGTATTATGAATACTTCGGTCCTGACTATACACTTCATGTTGCTCCGAGTAACAT 
               
               
                   
               
               
                 553 
                 Euc_007440_O_2 
                 GAATTGGCGATCACAATCTACTGTAGTCAATACTCAAGTGGGAGGTGTAAATAGATTCCA 
               
               
                   
               
               
                 554 
                 Euc_008994_O_1 
                 GATCATGTGTAATCAGTATATCAGGTTAGAAACAGTACTCTTGAGCTTAGCGGGCACTGT 
               
               
                   
               
               
                 555 
                 Euc_024580_O_2 
                 TCCTGTGAAGGTGGTCGACTCAATCAAAAGGTACCTTGTAGATAAGGTACCTTTTCTCAA 
               
               
                   
               
               
                 556 
                 Euc_037831_O_5 
                 GCATTTTATACGACGGATAGAGTCATGACCGTATCTTTCCATAAGTTTGGGGACTTCTTC 
               
               
                   
               
               
                 557 
                 Euc_034958_O_3 
                 CCTCGTTTCTTTGCGGTTCGGACGCATCATGGATGTATCTCCAAAGAGTAATCTGTCGAT 
               
               
                   
               
               
                 558 
                 Euc_022967_O_2 
                 AATTCAGATCTATTAGTGAAAGTTGGCATGAGTCTCAATCTTAGGGGAATACAGTACGGA 
               
               
                   
               
               
                 559 
                 Euc_008599_O_3 
                 TGATATGAGTATCATAACTCGGATGGTGACAACTTTGTACTACGGTCGGCACCGGTAGAT 
               
               
                   
               
               
                 560 
                 Euc_009919_O_1 
                 CATATACAATCTTAGTGGATTAGCTGAGGTCGAAACTGACAAGAGTGATCGCCCGTTGGA 
               
               
                   
               
               
                 561 
                 Euc_015820_O_2 
                 CATGGCTAACGCTGGCCCTAGCACTAATGGGAGCCAATTTTTCATATGCACTGTAAAGAC 
               
               
                   
               
               
                 562 
                 Euc_008327_O_2 
                 AACAAAGTCTACCTTGACATTAGCATCGGTAACCCTGTCGGGAAACTAGTCGGAAGAATT 
               
               
                   
               
               
                 563 
                 Euc_004604_O_2 
                 TGTGCTTGGATATACTGTATAAGCATTCTATATTATGCTTGTTGGCTTCGTTTTGAGGGA 
               
               
                   
               
               
                 564 
                 Euc_000966_O_1 
                 TTAACGTCGACCGCTTCTCTGCCCCTTGAATTTTCCCGAGAAAACCAGGAACCTGCCAAA 
               
               
                   
               
               
                 565 
                 Euc_001037_O_1 
                 TGTTGAATACGATGTATTATAATGTTGGTGTCTTGGTGAAATACAGAATTATGCTTGCGT 
               
               
                   
               
               
                 566 
                 Euc_004603_O_2 
                 ATCGCTGTGGCTGATCTCGTCGCTCCGGCTTTTCATAAAAATCATGGCTGAGGCAATCGA 
               
               
                   
               
               
                 567 
                 Euc_005465_O_2 
                 CTCGCAACCCTATATCTCGCTCAGGCGAAGAAGTCTGAGGATTTGAAAGAGGTGACTCAC 
               
               
                   
               
               
                 568 
                 Euc_006571_O_1 
                 TGTTTTTGGGTACACGCAGTTAGGATAACTAGCATGAAAGCCCGATCCCGCATATACAGG 
               
               
                   
               
               
                 569 
                 Euc_006786_O_2 
                 GAGGACTAGCCGGAACTTCATCGAACTCTCTCGGAGGGGTTACTACGATAACGTCAAGTT 
               
               
                   
               
               
                 570 
                 Euc_007057_O_1 
                 GATGGCTAGCACTGTGTAGAAAGGTGAATTTAAAGTACTTGTCTACACTGCTTATTAAAT 
               
               
                   
               
               
                 571 
                 Euc_008670_O_2 
                 TGAGACTGTCTTGGCGTGTATTTTGGAATAAACTATTATCACGTTTTGTTAAATATAATA 
               
               
                   
               
               
                 572 
                 Euc_009137_O_3 
                 TTACAAAATGGCTCTCAGAAAGTATCGAAAGGCCCTGCGCTATCTGGATATCTGCTGGGA 
               
               
                   
               
               
                 573 
                 Euc_010285_O_2 
                 AATTTTATGTTTGCTACTGCTTAGTGCTTAATGGACTTGCGTAGGTATTCAAATTACAGA 
               
               
                   
               
               
                 574 
                 Euc_010600_O_1 
                 TGGAACCGTGGTATCGGCTGACGTTATCCGTGATTTTAAGACTGGAGATAGTTTATGCTA 
               
               
                   
               
               
                 575 
                 Euc_011551_O_2 
                 CTTTGATGTATCCTCAGTGTACTGCTTTTAGCTATGTATAGATCGAGTCAACTCATTGAA 
               
               
                   
               
               
                 576 
                 Euc_020743_O_3 
                 TTTTTATTATTTACCTTCGCCTTTACGCTGCATACGTTAATAGGTTATTATTTCCTTCAA 
               
               
                   
               
               
                 577 
                 Euc_023739_O_1 
                 ATTTGTCCATGACAATCGTAGTCGAAGACACGATACGCTCTTAGATGGTACGGAAATCTG 
               
               
                   
               
               
                 578 
                 Euc_031985_O_2 
                 TGAATAGAGATAACTTTTCTGAGTGTGAATTGGATATTACGTTGCAAATAGCCGAATGAA 
               
               
                   
               
               
                 579 
                 Euc_032025_O_2 
                 GCTTTAGGTTAGGGATCCCTGTAAGCTGATGATAGATATTGGAGATGGTACTTGTAAGAT 
               
               
                   
               
               
                 580 
                 Euc_032173_O_1 
                 TGTTGTGTTTGGAAAGGTGCTGTCTGGGATGGATGTTGTCCACAAGATTGAGGCTGAAGG 
               
               
                   
               
               
                 581 
                 Euc_009143_O_1 
                 GGAAAGCGGGGAATGAGCATGTGGATATTATCTCTTTCTACAATGAAATATTCATTCCTT 
               
               
                   
               
               
                 582 
                 Euc_000349_O_1 
                 CATCAGGACGTTGACTCTAATTAAGACATATGTGACAGAGCGCCCTGTTAATGCGGTTAC 
               
               
                   
               
               
                 583 
                 Euc_000575_O_2 
                 CTTTAGGTTTGATCTGTCTGTTTTGTCTATCCTGCGAGTTTCGAGCATGTGCGTGTGTGA 
               
               
                   
               
               
                 584 
                 Euc_000804_O_1 
                 CAGCCCCAATAGATACTGGCTCTGTGCCGCTACTGAGAACAGTATTAAAATCTGGGACCT 
               
               
                   
               
               
                 585 
                 Euc_000805_O_2 
                 AAGAATGAAGCTGATATGAGTGATGGAACTACGGGGGCCATGAGCTCAAATAAGAAGGTC 
               
               
                   
               
               
                 586 
                 Euc_000806_O_1 
                 TGACTACAATTAGCACCTCACCATTATCGAACTGTATAATTGTGCTTGCCTGCTATTATT 
               
               
                   
               
               
                 587 
                 Euc_002248_O_4 
                 TTGAAGCGGAAATATATATTTATGCTACTACATAAGTAATGTACTACTTGACAAGATGAG 
               
               
                   
               
               
                 588 
                 Euc_003203_O_1 
                 TACTCGATGTGGTATAGAATTTATCCAATGTACTCCTAAATGTAGATACATCGTGTATTG 
               
               
                   
               
               
                 589 
                 Euc_003209_O_2 
                 GCTTCGTCTGATACCACTATCAAGATAATAGGCGTGAGCAATAGCTCTGGATCACAGCAC 
               
               
                   
               
               
                 590 
                 Euc_004429_O_4 
                 GGTCGGCTTGCTAGTGTATCTGATGACAAGAGCATATCACTCTATGATTACTCATGAAGG 
               
               
                   
               
               
                 591 
                 Euc_004607_O_3 
                 GAAAGGAGAAAAGCATGGAGATCGATCTCGGAAACCTCGCATTCGACGTCGATTTTCATC 
               
               
                   
               
               
                 592 
                 Euc_004682_O_1 
                 GATTCAGTACCCGGATTCGCAAGTCAACCGGTTGGAGATAACTCCACATAAGCGGTACCT 
               
               
                   
               
               
                 593 
                 Euc_005786_O_1 
                 TTCCATGTATCAAGCCGCATCAATGTTTGTCGCTGCAATTAACATGTGTGCAGTCGATCC 
               
               
                   
               
               
                 594 
                 Euc_005887_O_2 
                 TTCAGCGCATTGTGTAAATGTAGATAGGTGATATATTTCTCGTTGCAATGTAGGGTAAGA 
               
               
                   
               
               
                 595 
                 Euc_005981_O_2 
                 TCCAATAATCACATTTACCATCAACAGGCATCAGCAACATACTGTTGTAGTGTAATTAAT 
               
               
                   
               
               
                 596 
                 Euc_006766_O_1 
                 GGGCATTCTGACTACCTGCACTGTATAGCTGCACGGAACTCTTCTAGTCAGATTATAACA 
               
               
                   
               
               
                 597 
                 Euc_006769_O_1 
                 AATCGTCTGGTAGATTGTCAAAAACTAATAAACCTGTGATTGATCCGGATTCTAGTAATG 
               
               
                   
               
               
                 598 
                 Euc_006907_O_2 
                 AGTTGAGGATTCTCCACTATGACAGCTCTCATGGCTTGAATCTAAAGTCATCTGGTTTTC 
               
               
                   
               
               
                 599 
                 Euc_007518_O_1 
                 GAACAATCATTCTGTAGAACACTAGAGTCTATATGCTTGACTGTATCGGTTAATTAATTC 
               
               
                   
               
               
                 600 
                 Euc_007717_O_1 
                 AGATAGCGATAGAGTTATACTGCATGTACTGAGGTAAATGTTTTGATTACTCCACCCAAT 
               
               
                   
               
               
                 601 
                 Euc_007718_O_1 
                 AAGAATTGTTAGGAGGTGTATACTTTCTGTAACTGTATTCAATGAGCATACACCTGACGG 
               
               
                   
               
               
                 602 
                 Euc_007741_O_2 
                 CAACTCATATAATGACTGGATTCTGGCAACCGCGTCTTCAGACACAACAGTTGGACTATT 
               
               
                   
               
               
                 603 
                 Euc_007884_O_1 
                 AGTGTAAAAGGATGCCCCTAATAGATTATATGCCAAGTGTAGTATATATAATAGTGCTTT 
               
               
                   
               
               
                 604 
                 Euc_008258_O_2 
                 AAGAATCTACAGTTGTCTTATGCTACTCTATTACTCAATTATGCTGTGCTATTGATTGAG 
               
               
                   
               
               
                 605 
                 Euc_008465_O_4 
                 TCTGAATACATACTTTGTGGTCTCTATAAAAGACCAATGATACAGGCATGGTCATTAATT 
               
               
                   
               
               
                 606 
                 Euc_008616_O_5 
                 TAAATCTTCTCATGTGCCTGGCGTAAATTTTGCAGTTATTACTAGACCAAGATAGTTTCA 
               
               
                   
               
               
                 607 
                 Euc_008690_O_4 
                 ACATGGATTCGATCAATCGCCACATGACAACTAAAACAAGCGGTTCACGTGATTGTAATT 
               
               
                   
               
               
                 608 
                 Euc_008708_O_4 
                 AGATGAGTATGCTCGGGTGTATGATATTCGCAATTACAAGTGGAATGGATCGCATAATTT 
               
               
                   
               
               
                 609 
                 Euc_008850_O_5 
                 TCTTTGATTCTGTTGTATGGTGTATCTTATTGTATCTTCTATCTGCCCCCCATGTAATTC 
               
               
                   
               
               
                 610 
                 Euc_009072_O_1 
                 TTCGTTGTGTAGTACTGGGAGTTACTACTTGTATGTATGTAAATCATGTGGCGTCTGTCC 
               
               
                   
               
               
                 611 
                 Euc_009465_O_1 
                 GGAGATGTGTAATATGTCTGAGCGGTCACACTCTAGCTGTTACATGCGTAAAGTGGGGAG 
               
               
                   
               
               
                 612 
                 Euc_009472_O_3 
                 CCACCGTTGCGTAACTCGAATAGCCGGATTTTCGTTTTCGTTTTTATTTCCCCGTTAATT 
               
               
                   
               
               
                 613 
                 Euc_009550_O_1 
                 TGAGATGCTCTGTGTGAGGACTTTTACGAAACTTGAATGGCCCGTAAGGACAATAAGCTT 
               
               
                   
               
               
                 614 
                 Euc_010284_O_3 
                 TGGGTTGTTGCGACGGGTTCTACAGATAAGACTGTTAAGTTATTTGATCTACGCAAGATC 
               
               
                   
               
               
                 615 
                 Euc_010595_O_1 
                 GCAGAGGTGCCTACATATGCTTTAGAATGCTAGTAGCTTGGAAGTGCAACACGCTCGTGA 
               
               
                   
               
               
                 616 
                 Euc_010657_O_1 
                 AGTAAAGTTTAACGACTATGCATCTGTCGTAGTATCAGCCGGCTATGATCGTTCAGTGCG 
               
               
                   
               
               
                 617 
                 Euc_012636_O_2 
                 CGTTAGGATAGTCTTTAAAGGAGTTGGTGATTATTGATTTCCACCCAATATATGTAGCGT 
               
               
                   
               
               
                 618 
                 Euc_012748_O_2 
                 GAGCAAGCTACTTACAAAAATCGACAGCGTCTTTACCTATCTGAACAGACAGATGGCAGT 
               
               
                   
               
               
                 619 
                 Euc_012879_O_2 
                 TCCTTCCGACAAGTACCGTATTGCAAGTTGTGGTATGGACAATACGGTTAAAATCTGGTC 
               
               
                   
               
               
                 620 
                 Euc_015515_O_1 
                 TTTCACTCGATGACGGTTGGCCGGATAAATAATCGCTTATATAGTCCTAATAAGTTCCAT 
               
               
                   
               
               
                 621 
                 Euc_015724_O_3 
                 ATATGTAGGTGGTAGAGGTGTGGATATTGCATAGACCGAACCTCCGCAGGTCCGCATTCT 
               
               
                   
               
               
                 622 
                 Euc_016167_O_1 
                 CCATTGAACTACTTATGGATTACTTTATACATGAAATATCATGCCGGAGTAATTTTGAGT 
               
               
                   
               
               
                 623 
                 Euc_016633_O_3 
                 AGCATTAGAGACCTGGATTTTAGTCTAGATTCAGAGTTTTTGGCTACGACATCTACTGAT 
               
               
                   
               
               
                 624 
                 Euc_017485_O_3 
                 AAAGGTTTATCCCTCATTGGATTTGATATATAAACTGAGAGTGTTTTGCCCCCCATTAAA 
               
               
                   
               
               
                 625 
                 Euc_018007_O_1 
                 GTACAGCGTGTATTTCTTGTTACGATACTTGAGGGGTTAGAGGCACCTACGAATTAGGAA 
               
               
                   
               
               
                 626 
                 Euc_020775_O_3 
                 ATATCCTTATGAATGAAGTTTGGATGATAAGTGGCGCCAGACTTTCTACTCACCCTTTTT 
               
               
                   
               
               
                 627 
                 Euc_023132_O_3 
                 TGATCACATCGTTGTTTGCAATAAGACGTCATCAATTTATATCATGACTCTACAGGGACA 
               
               
                   
               
               
                 628 
                 Euc_023569_O_2 
                 TTTTCCCAGTGTACTGCGAGAGTGATGCTACATAAGTTTACTCTTGTGTCTAACTTTTCC 
               
               
                   
               
               
                 629 
                 Euc_023611_O_1 
                 AGATTCTACAGATGGCGCTATACGAGCTGTTATACGGACATTTTATGACCATACACATCC 
               
               
                   
               
               
                 630 
                 Euc_024934_O_3 
                 TGCTACGGGAAACCAGGACAAAACTTGTAGGATTTGGGACATACGAAACTTATCTAAGTC 
               
               
                   
               
               
                 631 
                 Euc_025546_O_1 
                 CAAGTCATATAGTTACAGTGTCGCATGACAGAACAATTAAGCTCTGGACTAGTAACGACG 
               
               
                   
               
               
                 632 
                 Euc_030134_O_2 
                 TGCCACATCGTAACCATCATAGCACTTATCATCTAATTATGGTGAAAGGGAGTTATATAT 
               
               
                   
               
               
                 633 
                 Euc_031787_O_5 
                 GTTTATACTTATAAACAACAGAGAGACAACTGTACAGGTGTTGTAAACACTCCCAGTGTG 
               
               
                   
               
               
                 634 
                 Euc_034435_O_1 
                 CTGTGTTTTAGCCCGAGGGCCAATCACTTAGTTGCTACTTCGTGGGATAATCAGGTACGG 
               
               
                   
               
               
                 635 
                 Euc_034452_O_3 
                 GCAAAGTAGAGTTTAAGTTTCGTTGTGCTTGGACCGGAAAACTCACATGCTTAGAGTTTA 
               
               
                   
               
               
                 636 
                 Euc_035789_O_5 
                 AAGATTTGGGCATAACTTGTATGAACTTTTTCTGTTGTCGACACTGTAATTACACGAGCT 
               
               
                   
               
               
                 637 
                 Euc_035804_O_4 
                 AAACAGATGCATGTATGCTTCATAACTCTATAGATATGGAAATGTCACTGTACACTGATC 
               
               
                   
               
               
                 638 
                 Euc_043057_O_2 
                 TTATTGGTGCACAGGACGGAAAATTGCGCATATATTCTATTTCAGGTGATACATTAACAG 
               
               
                   
               
               
                 639 
                 Euc_046741_O_1 
                 AGGCACAGACACTTGCCTAAACCAATATACAAGGCAGGTATTCTAAGGCGCACCGTGAAT 
               
               
                   
               
               
                 640 
                 Euc_047161_O_4 
                 CATGCGAAGGTTTCTGGGAATTTTCAGTAGAAAATTCGGTCGTGGCGGCCATCCTCGATA 
               
               
                   
               
               
                 641 
                 Pra_001766_O_1 
                 TTAAGCTGATAGCTTTAGTTCCTACGTGGAATGTATAAATGCACCATTGTCCATAAGGCA 
               
               
                   
               
               
                 642 
                 Pra_002927_O_2 
                 GGATGCTCTGGTTACATGACTACTCCTTAGGGAATCAGTCAGACATTTTAAATAACTTCC 
               
               
                   
               
               
                 643 
                 Pra_007642_O_2 
                 TCATTAAGCGGTACTGGCAGAGGACATGTCTATTTATACAAGCAAATGGTCCTATTGGCT 
               
               
                   
               
               
                 644 
                 Pra_013714_O_1 
                 ATGTTGGTCAGACCTCAAATATTGTACTCCCCACACTAGGGAGCATTTACGGTGAATATA 
               
               
                   
               
               
                 645 
                 Pra_016332_O_1 
                 TCCTCTCGACCCTTAGAGTCCTCTGCGAATCTTGTTGTTAGTTACTGTGTACGCTGTAAC 
               
               
                   
               
               
                 646 
                 Pra_021677_O_3 
                 AAGCATGTTTTGAATTTATGGTGGTGGCATGTGGATATTTGAACTTGGTTGAGAAAAATT 
               
               
                   
               
               
                 647 
                 Pra_027562_O_2 
                 CATTCCTATTGAAGGGTCAACCTTTAATTTTGGCTAGCAGGACTGTATAGGATTATATGC 
               
               
                   
               
               
                 648 
                 Pra_001504_O_2 
                 TTATTGTATTTTAGATTCTTGATGGCCATCTAAACTTCTGGCTGCTTGGTGCAACATTGA 
               
               
                   
               
               
                 649 
                 Pra_015211_O_2 
                 ATAGCTAATGATTCCATGCTATCCATGGTATCTACTTCACGATAATAAAGGTCTTAGTCC 
               
               
                   
               
               
                 650 
                 Pra_020421_O_2 
                 CACCTAATAGGCCTGAGTATTGCTCACCACTATGCTGATATGGGGAGCAATAACGTTAGT 
               
               
                   
               
               
                 651 
                 Pra_003187_O_2 
                 TTTCTTTTCACTTTGTACTAATGATCATTGTGACCACAAAATCTTTATACACAATACAGA 
               
               
                   
               
               
                 652 
                 Pra_015661_O_1 
                 CTTGTCACTATCCTCATATTGATATCACCTCGTGTATGTTGTGGGGTGGCAAAATTACTT 
               
               
                   
               
               
                 653 
                 Pra_013874_O_1 
                 TATTTTAACTCAGCGACTTACCAGCCTAGTAAGCAATGGGGAGCTTGCATGTATTAGTTT 
               
               
                   
               
               
                 654 
                 Pra_014615_O_1 
                 ATTCGTCCTGGTCCTTTAGGACATGTACTTATGTCCATGCAAGTGCTTCTTGCCTAAGCT 
               
               
                   
               
               
                 655 
                 Pra_004578_O_2 
                 TTCTAGGCGATATATATCGCCGTAACTTTGGATGTGTTAAGAATATAGGGGATCATTAGC 
               
               
                   
               
               
                 656 
                 Pra_023387_O_3 
                 AGTTGCAGAGTGTGTAGCAACTGATGAGCATAGTTGTTATGTTTCTCAACTCAGTTGCAC 
               
               
                   
               
               
                 657 
                 Pra_006970_O_1 
                 AAGAAACTCATACACTGGACAGGCCAACCTTCCAAATATGTGTTTAGAAAACCTTTGTCT 
               
               
                   
               
               
                 658 
                 Pra_010322_O_1 
                 AAGGGGTGCTATCCATATCTAGAATCTACCATGCTCAATGAGGTATCTTCATTAGTATAC 
               
               
                   
               
               
                 659 
                 Pra_022721_O_1 
                 ATCTAATGCTAGTTTATTGATTTCTATGATCCAAGACCTCGTCATAGATCAAGTGCCTAG 
               
               
                   
               
               
                 660 
                 Pra_023407_O_1 
                 TTGTTATTAAATACCATTCAATATGCTTATGATTCATGAATGCTTAAGAGATTCTGCTGC 
               
               
                   
               
               
                 661 
                 Pra_001945_O_2 
                 GCTTCTAAACTGTAGAAGCCTGTTATCTTTAGACTCGTGGTTATGTGAACTACTTTTACA 
               
               
                   
               
               
                 662 
                 Pra_008233_O_1 
                 GGCTGTGGGGATTCGAGCCTGATGGTTATGCACTGTGGCCAGCAAGATGTTGAAGTTTTA 
               
               
                   
               
               
                 663 
                 Pra_008234_O_4 
                 GCCTGATGGTTATGCACTGTAAGTGATCTGATTTGATTAACTATTTTATCAATTAATTTT 
               
               
                   
               
               
                 664 
                 Pra_022054_O_2 
                 ATGGTCATTATCCGAGATAGTGCGCTTTGTCATGGGAAAATGACTATTGAATGTGAGTTT 
               
               
                   
               
               
                 665 
                 Pra_012137_O_2 
                 TTTTCTGGTGCATCCTTAACACAGCTTGGTTACATGGTGAATTACAGTATTTGAAGGAGT 
               
               
                   
               
               
                 666 
                 Pra_012582_O_2 
                 AGATTTAATGCCACTTAGGTGATCGGTGACCCACTTGTACATATAGATGTTGGCGATGTT 
               
               
                   
               
               
                 667 
                 Pra_015285_O_2 
                 AAGAAATTCATCAATTCTTTGAAATTATTGTTCCCTTTTGATGCGGCCCCTTTCTGGAGG 
               
               
                   
               
               
                 668 
                 Pra_017229_O_1 
                 TAAAGTATATTTTAGCCGCTGTTGTTGTAAATTTATGTTTTTCATTGCTATCAACATTTA 
               
               
                   
               
               
                 669 
                 Pra_020724_O_2 
                 GGTTTTCCTATAAGATGTATGAATTCGCACTGTGGTGCAATTTTATGAATTAAACTCAAA 
               
               
                   
               
               
                 670 
                 Pra_004555_O_1 
                 TTTACTATTCCGTCTGGGCTTAGAGATGTACGTTAATTGGTCATTTAAGACGACTCAGTT 
               
               
                   
               
               
                 671 
                 Pra_004556_O_5 
                 TCAAATCTAGTCAATATCCGTGTTGAGCTAAACAAGCGCTGAAAGTTTGCTCGAATCAGC 
               
               
                   
               
               
                 672 
                 Pra_005729_O_2 
                 AGAAAGTTGTGTACTAATTTGTATTGTAACGTCCATTTATCCAACGAGTCCTCCATTCAT 
               
               
                   
               
               
                 673 
                 Pra_007395_O_3 
                 CAGTACTGTATTCGAAGATCCTGAAAATTTACTAAAACAAATGGAATATCAACAACCTAG 
               
               
                   
               
               
                 674 
                 Pra_009503_O_1 
                 TTGCTCTATATAATTTGTGCTCGTGTGTGTACTTGAAGATCCATCCTCACATAGTCCAAT 
               
               
                   
               
               
                 675 
                 Pra_011283_O_1 
                 GTGTGTATAGTTTTATAACACTCTATGGTATCACTACCACTATGGGCCTGTTTAGTCCAA 
               
               
                   
               
               
                 676 
                 Pra_012322_O_3 
                 GAAGCAGAATCAGCTTTGACCAGTATTTAGTGTCTTGTATACAATTCTTGTTTCAGTGAA 
               
               
                   
               
               
                 677 
                 Pra_023236_O_3 
                 AAATCAAGATTAAAATCCGAAACCAAGGCTAACCAGCAAACTGTGAGGTGTACATTGTTG 
               
               
                   
               
               
                 678 
                 Pra_000171_O_2 
                 TTCCAAGCAGAAGGGCACATGTTGTGACATCAAGTAGTAGATTGTTCTGCAGATTCTGGT 
               
               
                   
               
               
                 679 
                 Pra_000172_O_1 
                 GTTAATGTAATACATTTAGTTTTTAGATAACTGTTAATGTGTAGTAAAGCACTAGGAAGA 
               
               
                   
               
               
                 680 
                 Pra_001480_O_3 
                 GAGGCTTCAAAGGTTTTTGTGTCTTTTCTAGTTATTATAAACGCTTCATAGGTTCCTAGG 
               
               
                   
               
               
                 681 
                 Pra_001692_O_2 
                 GAAGATTGTAAGTTGGGTGAACTTTTTTACCACGCTAGGTTGATCTATTTTAAGACTCTT 
               
               
                   
               
               
                 682 
                 Pra_005313_ORF_O1 
                 AAAATAGCTGCGCGTACCACAAAGGTGACAAACGCCGGATTTCTCTTATCAGACTTGTCA 
               
               
                   
               
               
                 683 
                 Pra_006362_O_1 
                 TTTAATTATCATAGTTTTATTCCGGCTATCTTGATCATTCACGGAAGTCCCGAGAGTCAA 
               
               
                   
               
               
                 684 
                 Pra_006493_O_3 
                 GTGGAGTGAACGTGGTTACTTCAATGGATTACCCTTCTATCGTGTCATTAAACACTTTGT 
               
               
                   
               
               
                 685 
                 Pra_006983_O_1 
                 GCTAACTCTTCTAGTTGAGATCTCCATCAATTAATGGATACAAACATTGAGTTTCACTTT 
               
               
                   
               
               
                 686 
                 Pra_007665_O_1 
                 GGATCACTACTGGATTCCGTTACATTAGTTATTGCAAGTTGGTTATTATGTACGTTTATA 
               
               
                   
               
               
                 687 
                 Pra_012196_O_1 
                 ATGAACAAATGCAATTACCCTGTTTTATTCTATCCCGCTTTAATTAATATTGGTCATGTT 
               
               
                   
               
               
                 688 
                 Pra_013382_O_1 
                 TTTGCTTGTGGATTGTACTGTGGTACATGGTATAAATCTATAGGCTATGTCGATTATTTT 
               
               
                   
               
               
                 689 
                 Pra_016461_O_1 
                 ATATAAGATATAAGATATTGCCAGCAAACTATTTGACAGGTTATTTAATAAAGTGTGCTA 
               
               
                   
               
               
                 690 
                 Pra_017611_O_1 
                 TTTTAAATGTGGACAGAGGCACTATAAGAATGCGAAATATCGTCGGAGCACGACTAATTG 
               
               
                   
               
               
                 691 
                 Pra_019776_O_1 
                 ATAGACTAGTTCTACAAAGCCCTAGGATGATGGACTTCATTTCTTTTGCATTAAGATGAA 
               
               
                   
               
               
                 692 
                 Pra_020659_O_1 
                 GATTTCTTATGGGGTTGGAACATTCCTCGCTGCCTTCTGGTAATATTAGGTTATGCGTTT 
               
               
                   
               
               
                 693 
                 Pra_022559_O_3 
                 AATTGAGGTTGACTGTGTACTTCTCCAGTGGACAGGAGAAAGCGATAAAATTCAAACGTT 
               
               
                   
               
               
                 694 
                 Pra_024188_O_5 
                 AAGGAAGGGCAAATAGAGCTCGCGCTCAAGAAATACCTTAAATCGATACGGTATTTGGAT 
               
               
                   
               
               
                 695 
                 Pra_027973_O_2 
                 TAATTTAAGAGCTATGAAACAACTACCTTTTGGAATGGTTTTGTTTTTAGCATCCCAATT 
               
               
                   
               
               
                 696 
                 Pra_001353_O_1 
                 TTGTAAATTATGCTGGTTCCATATGGGGGTTAATCAGTATCCTGGTTATTTGTGACACCA 
               
               
                   
               
               
                 697 
                 Pra_001978_O_3 
                 GTTGTGAACTATCAATAGACGGGGATGGTCCTTTTTAGCTGCTCCTTAAGCAGCTCAAAT 
               
               
                   
               
               
                 698 
                 Pra_002810_O_2 
                 TCAATTCCGGTCATATGTAGACGACTATAATGTTGTTTGTGTCCTATAACTATAGTGTTG 
               
               
                   
               
               
                 699 
                 Pra_002811_O_1 
                 CATTTTACACCCTATAACAAAATATAGTGTCATAAGTTTACACCAGGTAACAACTCTATA 
               
               
                   
               
               
                 700 
                 Pra_002812_O_3 
                 ATGGAGAGTTTTATTCATTACATGAAAGAGTATGTCACCTTTCGTGCTCCATCTATTGAT 
               
               
                   
               
               
                 701 
                 Pra_003514_O_1 
                 TTTCACGTCCTGTATACTCACTCAAGCAACTTTAGGATGAAGAGCTAAAGTATATCAAAG 
               
               
                   
               
               
                 702 
                 Pra_004104_O_2 
                 AATGCACTCTTTATAAAGTGGGATGAGGTATGTGTTTCCTTCCTATTGGCTAACCTGAAT 
               
               
                   
               
               
                 703 
                 Pra_005595_O_1 
                 ATTGGGCAATCGTTATTGATTTTACCTATCGCTATCTCACTGTCCGCCAATTTAGTGTAA 
               
               
                   
               
               
                 704 
                 Pra_005754_O_1 
                 TTTCAGCGGATATAAAGTCTTCCAACTTGTAAACCGGTGCTGTGAAGATTAAAAGTCCTT 
               
               
                   
               
               
                 705 
                 Pra_006463_O_1 
                 GCTTTAGAGGCAATGGTAGATTATGAAGTCAACACCAGGGAGTTTGACCGTTTGGGACAT 
               
               
                   
               
               
                 706 
                 Pra_006665_O_1 
                 CATTCAATTTGACATTGGAGTTTCAAGGCATTCCAAGGATAGCATGTACACAAGTTGAAT 
               
               
                   
               
               
                 707 
                 Pra_006750_O_1 
                 CATAAAATTACTATGGAAGTTGGATCATTATCTATGCCATAGTGGAGTAGAACTAGATTT 
               
               
                   
               
               
                 708 
                 Pra_007030_O_1 
                 CTCTTGATTCTAGAATCTAAACTACTACCTTGCGGACATGACTGAGCATCTCTCTAACAG 
               
               
                   
               
               
                 709 
                 Pra_007854_O_1 
                 CAGGGTTGTGCTAGTTTAACATTTTAACTTAATGTAATCATGTAAGCTTTAGAGAGGTGG 
               
               
                   
               
               
                 710 
                 Pra_007917_O_1 
                 GTAAATGTTTACATTGAGGTCATGCATGAGTGTTAATTACGCTTTCACTACTGTTCACTT 
               
               
                   
               
               
                 711 
                 Pra_007989_ORF_O2 
                 AATTAAAGCTTGGTTGTATGATCATTTGGGATCGAGAGTAGATTATGATGCTCCTGGGCA 
               
               
                   
               
               
                 712 
                 Pra_008506_O_1 
                 TTATCTAGCTAGAAGTTGTGAAATTAAGAGGGATGTGAGGATTGGGTTATAACTAGTGTA 
               
               
                   
               
               
                 713 
                 Pra_008692_ORF_O2 
                 AATGAATCAGGCATTAAAGCGGGAATCATTTATGACTTGGCAACCTGAAAATTCTATTAA 
               
               
                   
               
               
                 714 
                 Pra_008693_O_2 
                 TTCTTGACGTTTTAATATGGTATGGTATTAAATTTGGAAGGCCTATTCGATTGTTTGCAA 
               
               
                   
               
               
                 715 
                 Pra_009170_O_1 
                 TTCTTATAACCTGTACGATTGCCGATATATCACCAATTTTGCTGATTTTAATCTGAGTTT 
               
               
                   
               
               
                 716 
                 Pra_009408_O_1 
                 CAATTTCATATTCGGGTTCAATGTAGTGCCTCTCATTTTAGGGTGATAGCATGAGTTTTT 
               
               
                   
               
               
                 717 
                 Pra_009522_O_1 
                 TCCACAAGTTAACATAGGTAACTATCGACTGAAGTGAACTGGGGGGCAGAAGCTAACTAT 
               
               
                   
               
               
                 718 
                 Pra_009734_O_2 
                 TTTAGATAGCCATTTACATTTTACTTATTATTGGACTTGTAAAGATTTTTGTACCCTTGT 
               
               
                   
               
               
                 719 
                 Pra_009815_O_4 
                 TTGCTGAAATATTTCAAGCTGAAAGTTATGATTCTGGCCAAGAAGTCTACTGAAAATTTG 
               
               
                   
               
               
                 720 
                 Pra_010670_O_2 
                 AAACATAAGTTTGGCCCAGATTCGGTTTATCATAAAATCTGGCTGCATATAAGGTGTCAG 
               
               
                   
               
               
                 721 
                 Pra_011297_O_1 
                 ATGTTCTAGAATTTGTCTAAGCTAGCTACTGGTGTTTAACTGATATGGAAAACTTTTGCC 
               
               
                   
               
               
                 722 
                 Pra_013098_O_2 
                 TTTGGGGAGTACTTTAGTCAATAAAAGTGAAGTGAATCATGATATAAAGGGTTTAAGTAA 
               
               
                   
               
               
                 723 
                 Pra_013172_O_2 
                 AGAAGTTACTAATTTGTAGATAAATTCTAACGAAGGTGATGATAGCATACACGTAATGAA 
               
               
                   
               
               
                 724 
                 Pra_013589_O_2 
                 GAATTTTGATGGTAGCGTATGGTTGAAGGAAAACTTGGATATATCATGTAAACATTTTTC 
               
               
                   
               
               
                 725 
                 Pra_013608_O_1 
                 TTAATGAACCGCTTTTTCCTTGAGAGGCTATGAATGCCTGTAGAACTAATCCTTTAAGTA 
               
               
                   
               
               
                 726 
                 Pra_014299_O_2 
                 TTTCTCTAACACTATATTTTCTGGTATGACCGCTCTACATTGTATATTAACCCTTGCAAA 
               
               
                   
               
               
                 727 
                 Pra_014498_O_1 
                 TATATTCACTGTGCTGGGATTATCCTCTCCCCTTTTTGACCCACTGTTGTGTGTATTTGA 
               
               
                   
               
               
                 728 
                 Pra_014548_O_1 
                 GAGCATACAGCGTTATCTTTGAGACGAGTCATCAATGATAATATCCTCGTAAAAGGTTAC 
               
               
                   
               
               
                 729 
                 Pra_014610_O_2 
                 TTTATTCAATTACGACGGATTCAGTTGGCCTTTTGTAACATTCAAGTATCCATCTATCAC 
               
               
                   
               
               
                 730 
                 Pra_016090_O_2 
                 ATGTTCAGGGGTATTAAAAATTCAGAGGATAAATTTCCTCACTCTCAAGTGTTAGATGGT 
               
               
                   
               
               
                 731 
                 Pra_016722_O_2 
                 CAAAGTCTAGACGTTAATGTTTTGGAACTCTTTTTTCGAATTTGTGCCTATTGAATCACT 
               
               
                   
               
               
                 732 
                 Pra_016785_O_3 
                 TATAAATATATTGTACTGGGGATCCAAGACATGGCAATATATGTCGAGATTTTCATTTTC 
               
               
                   
               
               
                 733 
                 Pra_017094_O_3 
                 CTTTTGCATGAGTTCAAATGTCTTTGTGACATATTGTCTTGAACCACCGAGGATATATCA 
               
               
                   
               
               
                 734 
                 Pra_017527_O_2 
                 GTTTGTATGTCCAATAGATTATAACCTATTTACTGTGACACTATTCTTCACACCCATGTC 
               
               
                   
               
               
                 735 
                 Pra_017591_ORF_O2 
                 AGATCTAGTTGTTTCAGCATCGTTGGACCAAACTGTTCGTGTATGGGATATAAGTGGCCT 
               
               
                   
               
               
                 736 
                 Pra_017769_O_2 
                 TGCCGTATCAAAAGATTGGTACTTCCTTATGGACACACAAGATCGTAAGCATGGCTGAAT 
               
               
                   
               
               
                 737 
                 Pra_018047_O_2 
                 TTGATGGCCACATGAGTTGTTTATACAAGTCGTTGTTTTATGAGAGAACCTTCTTCAGAT 
               
               
                   
               
               
                 738 
                 Pra_018414_O_1 
                 ATTTCTATAGTGCCATATGCTTGTCGGTTGTCATTGACCTCTAATAGAATAGCCAGAGTA 
               
               
                   
               
               
                 739 
                 Pra_018986_O_1 
                 TTCACGGCAGTTGAACTAGTCATAGTGGAATATTATTTAAATGGTGTATTCTAGTCACAT 
               
               
                   
               
               
                 740 
                 Pra_019479_ORF_O1 
                 TGCAGGCGCTCTATAGTTCTGTTCTCTAGCATGAAGTGTGTATTTTATCTATTGTGGACC 
               
               
                   
               
               
                 741 
                 Pra_020144_O_1 
                 TGTCTTTAATCTTCAGGGTTCGTTACTAACAATTGAGCTCAAATCTCTATTCTGACCAGC 
               
               
                   
               
               
                 742 
                 Pra_022480_O_1 
                 CATTTATAGAGTTGTGCAAAATCACCCATAATGCTATGAATTGACAGGTGACTGTAATCT 
               
               
                   
               
               
                 743 
                 Pra_023079_O_2 
                 GGAGAAAATTTCCTATCCCTTTGTGGGTGTGTGAAAAACGAAATATAGAGGAACAATGTG 
               
               
                   
               
               
                 744 
                 Pra_026739_O_2 
                 ACCAATCATTTATTTGCAGTGTAGTTGATATGAAGGGAGAAATATGACAGTTGGTTTCAA 
               
               
                   
               
               
                 745 
                 Pra_026951_O_2 
                 AAGTTAATGTTCTCATAGGTTATTCATTGGAGTTGTCTCGTATGTACGCTGTGCCGTAGT 
               
               
                   
               
               
                 746 
                 Pra_026529_O_2 
                 CTCATAAATTGAGGCTTGCCTACGTTAATTGTTATATATGGAGAGCCATGCTAATTGTTA 
               
               
                   
               
               
                 747 
                 Euc_006366_O_2 
                 GCAGATCATGTAATTGTATCTCAAATTATAGTATCCGTATTCTGTACAAATGCTCCGGAA 
               
               
                   
               
               
                 748 
                 Euc_017378_O_1 
                 TCTTTACGCAGATGGTGACTGAAGCTGGTTCCGAGATCGGCATATGTAGCTGGTAGAGGT 
               
               
                   
               
               
                 749 
                 Pra_000888_O_1 
                 TTCACATTGAGGGTTGCCGTCGGTATTCGCCGATGATATCCTGTTTTACGCGCAACAGTT 
               
               
                   
               
               
                 750 
                 Pra_014166_O_1 
                 TCATTATTTAGGGTGCAGGCTGTATAAAATGTTGTAAATTGTAGTATCAATGTGTACAAT 
               
               
                   
               
               
                 751 
                 Pra_003189_O_1 
                 GCATTCACCACGACAGTAAAGTAATCATTATGATTACTAATGTATTGCTTTCATGGGGTG 
               
               
                   
               
               
                 752 
                 Pra_009356_O_4 
                 AAAGGGTATATTTTGTCTCATGTTGGGGTGATAATTCTCCCTGAAAGTCTCCAAAATATA 
               
               
                   
               
               
                 753 
                 Pra_000065_ORF_O_2 
                 AAATTTCCGGTTGCCATAGTCTAGTGGGGTGAGGGTTCATTCTAGGGGATTTATTGTGTT 
               
               
                   
               
               
                 754 
                 Pra_014197_ORF_O1 
                 GCAGTGATAAAGGTACTTCTTGGTGATAATCCTAAAGCCTTACCCATGGATATCCAGCCT 
               
               
                   
               
               
                 755 
                 Pra_009081_O_2 
                 TTCTTTAACAAGGTAAAAATCCCCCCCTTGGCATGTAGCTCAATTAGTTGTAATGGAACT 
               
               
                   
               
               
                 756 
                 Pra_013417_O_1 
                 AGTTGTAAACAGTGTAATAAGGAGCAGAAGTTGTGATAGCTTTTAGGAACGATAGACTTT 
               
               
                   
               
               
                 757 
                 Pra_005755_O_1 
                 TGAACCAATTCTTGTATATTAGATATGTAACATGTATGAATGTCCATAGAGCAGAGCTTT 
               
               
                   
               
               
                 758 
                 Pra_006670_O_2 
                 AGCCAGGCACGCTTAACTAAATTTCGTTTAGTTCACCATGACTATTCGTTGAACTTAATG 
               
               
                   
               
               
                 759 
                 Pra_007027_O_1 
                 CAAAACCCCTTGTAGGGTGGACTTCTGTTGTATCCAATTTTTATGGCATAATTAGCTAGT 
               
               
                   
               
               
                 760 
                 Pra_007276_O_1 
                 AATTTGGTGATTATTCCTTACCATATCGTACTGTACAGATACGGTAAGGTCGAAATATAT 
               
               
                   
               
               
                 761 
                 Pra_007390_ORF_O1 
                 CATGCCGTGATCGGTCGATTGCATTAAGTGCTGCAAGGATCAAATAGTGGCACTGTCATG 
               
               
                   
               
               
                 762 
                 Pra_012648_ORF_O1 
                 CAAACATAAATAAGGTTGCTACTTTAAAGGGACATACGGAACGAGTTACTGATGTGGCAT 
               
               
                   
               
               
                 763 
                 Pra_013171_O_2 
                 ATTTATGGATGAGGTACTCCTTATGAATATCTTCAAACTAAGAAATAACTATATATGCAA 
               
               
                   
               
               
                 764 
                 Euc_045414_O_2 
                 CTTGGTTTTTGTTGAGCTTTCTATTTCAAGCAATTTGTGATTGGGGGGTTCTGCATTCTT 
               
               
                   
               
               
                 765 
                 Euc_044328_O_2 
                 ATGTCTAAAGAGCCGTGATCTATGAGTAGATTAGAAACCGCCTTTTTAGTTGCAAACGCC 
               
               
                   
               
               
                 766 
                 Euc_015615_O_2 
                 TTGCAACAAGGTATACTTAGTCAGTCCTTGTTATGTATGTCTTTTGTCAACCCTTCAGGG 
               
               
                   
               
               
                 767 
                 Euc_017239_O_3 
                 GGCGGAATCCCTTTGTTCTTTCGAGCTTTACGTGACAAGTCGGCCAGAAAGCAGTAGCAT 
               
               
                   
               
               
                 768 
                 Euc_018643_O_3 
                 TTGATGTACGAGCCGCTATATCTAATTCTGCCTCCCAGTCACTGCCAAGTTTTACTCTTC 
               
               
                   
               
               
                 769 
                 Euc_019127_O_5 
                 GTCTTGCATGTCAGCTATTATACAGTCCTGTTTATAGTCCTGTGATGTAATAAAAAGCTG 
               
               
                   
               
               
                 770 
                 Euc_022624_O_3 
                 AAGTAGGAGATCGTGTAGAGAGAATACTTTCTGCTCTCAGCGGCGAAGAGGTTTGTCTGC 
               
               
                   
               
               
                 771 
                 Euc_032424_O_1 
                 AATTGTGAGTAGAATAGGAGAAACTTTTGTACAAGATTAATACGTGTGGCATAATAAGAT 
               
               
                   
               
               
                 772 
                 Euc_037472_O_1 
                 TGATGTGCAGTTTACATTATTATGGTTCGAGTATTATTTAGCTGCCCTATCTTAAGTCAT 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 15 
               
             
            
               
                   
               
               
                 Peptide Table. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Patent 
                 Patent 
                   
               
               
                 Protein 
                   
                   
                 ORF 
                 ORF 
               
               
                 SEQ ID 
                 Target 
                 Patent PEPTIDE Sequence 
                 start 
                 stop 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 261 
                 CDK type A 
                 MGDGSLGSGGRGNSGGGGGGGSRPEWLQQYDLIGKIGEGTYGLVFLARIKHPST 
                 387 
                 1820 
                   
               
               
                   
                   
                 NRGKYIAIKKFKQSKDGDGVSPTAIREIMLLREISHENVVKLVNVHINPVDMSL 
               
               
                   
                   
                 YLAFDYADHDLYEIIRHHRDKVNQAINPYTVKSLLWQLLNGLNYLHSNWIIHRD 
               
               
                   
                   
                 LKPSNILVMGEGEEQGVVKIADFGLARVYQAPLKPLSDNGVVVTIWYRAPELLL 
               
               
                   
                   
                 GAKHYTSAVDMWAVGCIFAELLTLKPLFQGQEVKANPNPFQLDQLDKIFKVLGH 
               
               
                   
                   
                 PTQEKWPMLVNLPHWQSDVQHIQRHKYDDNALGNVVRLSSKNATFDLLSKMLEY 
               
               
                   
                   
                 DPQKRITAAQALEHEYFRMEPLPGRNALVPSSPGDKVNYPTRPVDTTTDIEGTT 
               
               
                   
                   
                 SLQPSQSASSGNAVPGNMPGPHVVTNRPMPRPMHMVGMQRVPASGMAGYNLNPS 
               
               
                   
                   
                 GMGGGMNPSGIPMQRGVANQAQQSRRKDPGMGMGGYPPQQKQRRF 
               
               
                   
               
               
                 262 
                 CDK type A 
                 MEKYQQLAKIGEGTYGIVYKAKDKKSGELLALKKIRLEAEDEGIPSTAIREISL 
                 99 
                 1007 
               
               
                   
                   
                 LKQLQHPNIVRLYDVVHTEKKLTLVFEFLDQDLKKYLDACGDNGLEPYTVKSFL 
               
               
                   
                   
                 YQLLQGIAFCHEHRVLHRDLKPQNLLINMEGELKLADFGLARAFGIPVRNYTHE 
               
               
                   
                   
                 VVTLWYRAPDVLMGSRKYSTQVDIWSVGCIFAEMVNGRPLFPGSSEQDQLLRIF 
               
               
                   
                   
                 KTLGTPSLKTWPGMAELPDFKDNFPKYVVQSFKKICPKKLDKTGLDLLSRMLQY 
               
               
                   
                   
                 DPAKRISAEQAMGHPYFKDLKLRKPKAAGPGP 
               
               
                   
               
               
                 263 
                 CDK type A 
                 MDQYEKIEKIGEGTYGVVYKAIDRSTNKTIALKKIRLEQEDEGVPSTAIREISL 
                 120 
                 1004 
               
               
                   
                   
                 LKEMQHGNIVKLQDVVHSERRLYLVFEYLDLDLKKHMDSCPEFSKDTHTIKMFL 
               
               
                   
                   
                 YQILRGISYCHSHRVLHRDLKPQNLLLDRRTNSLKLADFGLARAFGIPVRTFTH 
               
               
                   
                   
                 EVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMVNRRPLFPGDSEIDELFKI 
               
               
                   
                   
                 FRIMGTPNEDSWPGVTSLPDFKSTFPKWASQDLKTVTPTVDPAGIDLLSKMLCM 
               
               
                   
                   
                 DPRRRITAKVALEHEYFKDVGVIP 
               
               
                   
               
               
                 264 
                 CDK type A 
                 MVMKSKLDKYEKLEKLGEGTYGVVYKAQDKTTKEIYALKKIRLESEDEGIPSTA 
                 23 
                 937 
               
               
                   
                   
                 IREIALLKELQHPNVVRIHDVIHTNKKLILVFEFVDYDLKKFLHNFDKGIDPKI 
               
               
                   
                   
                 VKSLLYQLVRGVAHCHQQKVLHRDLKPQNLLVSQEGILKLGDFGLARAFGIPVK 
               
               
                   
                   
                 NYTNEVVTLWYRAPDILLGSKNYSTSVDIWSIGCIFVEMLNQKPLFPGSSEQDQ 
               
               
                   
                   
                 LKKIFKIMGTPDATKWPGIAELPDWKPENFEKYPGEPLNKVCPKMDPDGLDLLD 
               
               
                   
                   
                 KMLKCNPSERIAAKNAMSHPYFKDIPDNLKKLYN 
               
               
                   
               
               
                 265 
                 CDK type A 
                 MDQYEKVEKIGEGTYGVVYKAIDRLTNETIALKKIRLEQEDEGVPSTAIREISL 
                 149 
                 1033 
               
               
                   
                   
                 LKEMQHGNIVRLQDVVHSENRLYLVFEYLDLDLKKHMDSSPDFAKDPRLVKIFL 
               
               
                   
                   
                 YQILRGIAYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPVRTFTH 
               
               
                   
                   
                 EVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMVNQRPLFPGDSEIDELFKI 
               
               
                   
                   
                 FRILGTPNEDTWPGVTALPDFKSAFPKWPAKNLQDMVPGLNSAGIDLLSKMLCL 
               
               
                   
                   
                 DPSKRITARSALEHEYFKDIGFVP 
               
               
                   
               
               
                 266 
                 CDK type B-1 
                 MEKYEKLEKVGEGTYGKVYKAKDKATGQLVALKKTRLEMDEEGVPPTALREVSL 
                 199 
                 1116 
               
               
                   
                   
                 LQLLSQSLYVVRLLSVEHVDGGSKRKPMLYLVFEYLDTDLKKFIDSHRKGPNPR 
               
               
                   
                   
                 PVPAATVQNFLYQLLKGVAHCHSHGVLHRDLKPQNLLVDKEKGILKIADLGLGR 
               
               
                   
                   
                 AFTVPLKSYTHEVVTLWYRAPEVLLGSAHYSIGVDMWSVGCIFAEMVRRQALFP 
               
               
                   
                   
                 GDSEFQQLLHIFRLLGTPTEKQWPGVTTLRDWHVYPQWEPQNLARAVPSLGPDG 
               
               
                   
                   
                 VDLLSKMLKYDPAERISAKAALDHPFFDSLDKSQF 
               
               
                   
               
               
                 267 
                 CDK type B-2 
                 MERPATAAVSAMEAFEKLEKVGEGTYGKVYRAREKATGKIVALKKTRLHEDEEG 
                 41 
                 982 
               
               
                   
                   
                 VPPTTLREISILRMLSRDPHIVRLMDVKQGQNKEGKTVLYLVFEYMETDLKKYI 
               
               
                   
                   
                 RGFRSSGESIPVNIVKSLMYQLCKGVAFCHGHGVLHRDLKPHNLLMDKKTLTLK 
               
               
                   
                   
                 IADLGLARAFTVPIKKYTHEILTLWYRAPEVLLGATHYSTAVDMWSVGCIFAEL 
               
               
                   
                   
                 VTKQALFPGDSELQQLLHIFRLLGTPNEKMWPGVSSLMNWHEYPQWKPQSLSTA 
               
               
                   
                   
                 VPNLDKDGLDLLSQMLHYEPSRRISAKAAMEHPYFDDVNKTCL 
               
               
                   
               
               
                 268 
                 CDK type C 
                 MGCVLGREVSSGIVTESKGRDSSEVETSKRDDSVAAKVEGEGKAEEVRTEETQK 
                 291 
                 2042 
               
               
                   
                   
                 KEKVEDDQQSREQRRRSKPSTKLGNLPKHIRGEQVAAGWPSWLSDICGEALNGW 
               
               
                   
                   
                 IPRRANTFEKIDKIGQGTYSNVYKAKDLLTGKIVALKKVRFDNLEPESVRFMAR 
               
               
                   
                   
                 EILILRHLDHPNVVKLEGLVTSRMSCSLYLVFEYMEHDLAGLAASPAIKFTEPQ 
               
               
                   
                   
                 VKCYMHQLLSGLEHCHNRRVLHRDIKGSNLLIDNGGVLKIGDFGLASFYDPDHK 
               
               
                   
                   
                 HRMTSRVVTLWYRPPELLLGANDYGVGIDLWSAGCILAELLAGKPIMPGRTEVE 
               
               
                   
                   
                 QLHKIYKLCGSPSEEYWKKYKLPNATLFKPREPYRRCIRETFKDFPPSSLPLIE 
               
               
                   
                   
                 TLLAIDPAERGTATDALQSEFFRTEPYACEPSSLPQYPPSKEMDAKKRDDEARR 
               
               
                   
                   
                 LRAASKGQADGSKKERTRDRRVRAVPAPEANAELQHNIDRRRLISHANAKSKSE 
               
               
                   
                   
                 KFPPPHQDGALGFPLGASHRFDPAVVPPDVPFTSTSFTSSKEHDQTWSGPLVDP 
               
               
                   
                   
                 PGAPRRKKHSAGGQRESSKLSMGTNKGRRADSHLKAYESKSIA 
               
               
                   
               
               
                 269 
                 CDK type C 
                 MYSKSSAVDDSRESPKDRVSSSRRLSEVKTSRLDSSRRENGFRARDKVGDVSVM 
                 107 
                 2236 
               
               
                   
                   
                 LIDKKVNGSARFCDDQIEKKSDRLQKQRRERAEAAAAADHPGAGRVPKAVEGEQ 
               
               
                   
                   
                 VAAGWPVWLSAVAGEAIKGWLPRRADTFEKLDKIGQGTYSSVYKARDVTNNKIV 
               
               
                   
                   
                 ALKRVRFDNLDTESVKFMAREIHILRMLDHPNVIKLEGLITSRMSCSLYLVFEY 
               
               
                   
                   
                 MEHDLTGLASRPDVKFSEPQIKCYMKQLLSGLDHCHKHGVLHRDIKGSNLLIDN 
               
               
                   
                   
                 NGILKIADFGLASVFDPHQTAPLTSRVVTLWYRPPELLLGASRYGVEVDLWSTG 
               
               
                   
                   
                 CILGELYTGKPILPGKTEVEQLHKIFKLCGSPSDDYWRRLHLPHAAVFKPPQPY 
               
               
                   
                   
                 RRCVAEIFKELPPVALGLLETLISVDPSQRGTAAFALRSEFFTASPLPCDPSSL 
               
               
                   
                   
                 PKYPPSKEIDMKLREEEARRRGAAGGKNELEKRGTKDSRTNSAYYPNAGQLQVK 
               
               
                   
                   
                 QCHSNANGRSEIFGPYQEKTVSGFLVAPPKQARVSKETRKDYAEQPDRASFSGP 
               
               
                   
                   
                 LVPGPGFSKAGKELGHSITVSRNTNLSTLSSLVTSRTGDNKQKSGPLVSESANQ 
               
               
                   
                   
                 ASRYSGPIREMEPARKQDRRSHVRTNIDYRSREDGNSSTKEPALYGRGSAGNKI 
               
               
                   
                   
                 YVSGPLLVSSNNVDQMLKEHDRRIQEHARRARFDKARVGNNHPQAAVDSKLVSV 
               
               
                   
                   
                 HDAG 
               
               
                   
               
               
                 270 
                 CDK type C 
                 MGCIPTIISDGRRRSAAPDKRRPRPRRSSSEGEAPPHATAAGSEGGESARGAPG 
                 82 
                 1749 
               
               
                   
                   
                 KERPEPAPRFVVRSPQGWPPWLVAAVGHAIGEFVPRCADSFRKLAKIGEGTYSN 
               
               
                   
                   
                 VYKARDLVTGKTVALKKVRFDNLEAESIKFMAREILVLTRLNHPNVIKLEGPVT 
               
               
                   
                   
                 SRMSSGLYLAFEYMEHDLSGIAARQNGKFTEPQVKCFMRQLLSGLEHCHNHDVL 
               
               
                   
                   
                 HRDIKCSNLLIDNEGNLKIADFGLATFYDPERKQVMTNRVVTLWYRAPELLLGA 
               
               
                   
                   
                 TSYGIGIDLWSAGCILAELLYGKPIMPGRTEVEQLHKIFKLCGSPSEAYWNKFK 
               
               
                   
                   
                 LPNANIFKPPQPYARCIAETFKDFPPSALPLLETLLSIDPDERGTATTALNSEF 
               
               
                   
                   
                 FAAEPHACEPSSLPKYPPSKEMDLKLIKEKTRRDSSKRPSAIHGSRRDGIHDRA 
               
               
                   
                   
                 GRVIPAPEATAENQATLHRPRAMKKANPMSRSEKFPPAHMDGVVGSSANAWLSG 
               
               
                   
                   
                 PASNAAPDSRRHRSLNQNPSSSVGKASTGSSTTQETLKVAPELLQVGSSSLHPC 
               
               
                   
                   
                 HRMLVYGSNLTIRSK 
               
               
                   
               
               
                 271 
                 CDK type C 
                 MGCICAKQADRGPASPGSGILTGAGTGTGTRSSKIPSGLFEFEKSGVKEHGGRS 
                 151 
                 1560 
               
               
                   
                   
                 GELRKLEEKGSLSKRLRLELGFSHRYVEAEQAAAGWPSWLTAVAGDAIQGLVPL 
               
               
                   
                   
                 KADSFEKLEKIGQGTYSSVFRARELANGRMVALKKVRFDNFQPESIQFMAREIS 
               
               
                   
                   
                 ILRRLDHPNIMKLEGIITSRMSNSIYLVFEYMEHDLYGLISSPQVKFSDAQVKC 
               
               
                   
                   
                 YMKQLLSGIEHCHQHGVIHRDVKSSNILVNNEGILRIGDFGLANILNPKDRQQL 
               
               
                   
                   
                 TSHVVTLWYRPPELLMGSTSYGVTVDLWSVGCVFAELMFRKPILRGRTEVEQLH 
               
               
                   
                   
                 KIFKLCGSPPDGYWKMCKVPQATMFRPRHAYECTLRERCKGIATSAMKLMETFL 
               
               
                   
                   
                 SIEPHKRGTASSALISEYFRTVPYACDPSSLPKYPPNKEIDAKHREEARRKKAR 
               
               
                   
                   
                 SRVREAEVGKRPTRIHRASQEQGFSSNIAPKEKRSYA 
               
               
                   
               
               
                 272 
                 CDK type C 
                 MAVAAPGHLNVNESPSWGSRSVDCFEKLEQIGEGTYGQVYMAKEKKTGEIVALK 
                 82 
                 1644 
               
               
                   
                   
                 KIRMDNEREGFPITAIREIKILKKLHHENVIKLKEIVTSPGPEKDEQGRPEGNK 
               
               
                   
                   
                 YKGGIYMVFEYMDHDLTGLADRPGMRFSVPQIKCYMRQLLTGLHYCHINQVLHR 
               
               
                   
                   
                 DIKGSNLLIDNEGNLKLADFGLARSFSNDHNANLTNRVITLWYRPPELLLGATK 
               
               
                   
                   
                 YGPAVDMWSVGCIFAELLHGKPIFPGKDEPEQLNKIFELCGAPDEINWPGVSKI 
               
               
                   
                   
                 PWYNNFKPTRPMKRRLREVFRHFDRHALELLERMLTLDPSQRISAKDALDAEYF 
               
               
                   
                   
                 WADPLPCDPKSLPKYESSHEFQTKKKRQQQRQHEETAKRQKLQHPPQHPRLPPV 
               
               
                   
                   
                 QQSGQAHAQMRPGPNQLMHGSQPPVATGPPGHHYGKPRGPSGGAGRYPSSGNPG 
               
               
                   
                   
                 GGYNHPSRGGQGGSGGYNSGPYPPQGRAPPYGSSGMPGAGPRGGGGNNYGVGPS 
               
               
                   
                   
                 NYPQGGGGPYGGSGAGRGSNMMGGNRNQQYGWQQ 
               
               
                   
               
               
                 273 
                 CDK type C 
                 MGCICTKGILPAHYRIKDGGLKLSKSSKRSVGSLRRDELAVSANGGGNDAADRL 
                 626 
                 2782 
               
               
                   
                   
                 ISSPHEVENEVEDRKNVDFNEKLSKSLQRRATMDVASGGHTQAQLKVGKVGGFP 
               
               
                   
                   
                 LGERGAQVVAGWPSWLTAVAGEAINGWVPRRADSFEKLEKIGQGTYSSVYRARD 
               
               
                   
                   
                 LETNTIVALKKVRFANMDPESVRFMAREIIIMRKLDHPNVMKLEGLITSRVSGS 
               
               
                   
                   
                 LYLVFEYMDHDLAGLAATPSIKLTESQIKCYMQQLLRGLEYCHSHGVLHRDIKG 
               
               
                   
                   
                 SNLLVDNNGNLKIGDFGLATFFRTNQKQPLTSRVVTLWYRPPELLLGSSDYGAS 
               
               
                   
                   
                 VDLWSSGCILAELFAGKPIMPGRTEVEQLHKIFKLCGSPSEEYWKKSKLPHATI 
               
               
                   
                   
                 FKPQQPYKRCLLETFKDFPSSALGLLDVLLAVEPECRGTASSALQNEFFTSNPL 
               
               
                   
                   
                 PSDPSSLPKYPSSKEFDARLRDEEARKHKATAGKARGLESIRKGSKESKVVPTS 
               
               
                   
                   
                 NANADLKASIQKRQEQSNPRSTGEKPGGTTQNNFILSGQSAKPSLNGSTQIGNA 
               
               
                   
                   
                 NEVEALIVPDRELDSPRGGAELRRQRSFMQRRASQLSRFSNSVAVGGDSHLDCS 
               
               
                   
                   
                 REKGANTQWRDEGFVARCSHPDGGELAGKHDWSHHLLHRPISLFKKGGEHSRRD 
               
               
                   
                   
                 SIASYSPKKGRIHYSGPLLPSGDNLDEMLKEHERQIQNAVRKARLDKVKTKREY 
               
               
                   
                   
                 ADHGQTESLLCWANGR 
               
               
                   
               
               
                 274 
                 CDK type D 
                 MDPDPSPDPDPPKSWSIHTRREIIARYEILERVGSGAYSDVYRGRRLSDGLAVA 
                 13 
                 1467 
               
               
                   
                   
                 LKEVHDYQSAFREIEALQILRGSPHVVLLHEYFWREDEDAVLVLEFLRSDLAAV 
               
               
                   
                   
                 IADASRRPRDGGGGGAAALRAGEVKRWMLQVLEGVDACHRNSIVHRDLKPGNLL 
               
               
                   
                   
                 ISEEGVLKIADFGQARILLDDGNVAPDYEPESFEERSSEQADILQQPETMEADT 
               
               
                   
                   
                 TCPEGQEQGAITREAYLREVDEFKAKNPRHEIDKETSIFDGDTSCLATCTTSDI 
               
               
                   
                   
                 GEDPFKGSYVYGAEEAGEDAQGCLTSCVGTRWFRAPELLYGSTDYGLEVDLWSL 
               
               
                   
                   
                 GCIFAELLTLEPLFPGISDIDQLSRIFNVLGNLSEEVWPGCTKLPDYRTISFCK 
               
               
                   
                   
                 IENPIGLESCLPNCSSDEVSLVRRLLCYDPAARATPMELLQDKYFTEEPLPVPI 
               
               
                   
                   
                 SALQVPQSKNSHDEDSAGGWYDYNDMDSDSDFEDFGPLKFTPTSTGFSIQFP 
               
               
                   
               
               
                 275 
                 CDK type D 
                 MDPDPSPSPDPPKSWSIHTRREIIARYEILERVGSGAYSDVYRGRRLSDGLAVA 
                 113 
                 1558 
               
               
                   
                   
                 LKEVHDYQSAFREIEALQILRGSPHVVLLHEYFWREDEDAVLVLEFLRSDLAAV 
               
               
                   
                   
                 IADASRRPRGGGVAPLRAGEGKRWMLQVLEGVDACHRNSIVHRDLKPGNLLISE 
               
               
                   
                   
                 EGVLKIADFGQARILLDDGNVAPDYEPESFEERSSEQADILQQPETMEADTTCP 
               
               
                   
                   
                 EGQEQGAITREAYLREVDEFKAKNPRHEIDKETSIYDGDTSCLATCTTSDIGED 
               
               
                   
                   
                 PFKGSYVYGAEEAGEDAQGSLTSCVGTRWFRAPELLYGSTDYGLEVDLWSLGCI 
               
               
                   
                   
                 FAELLTLEPLFPGISDIDQLSRIFNVLGNLSEEVWPGCTKLPDYRTISFCKIEN 
               
               
                   
                   
                 PIGLESCLPNCSSDEVSLVRRLLCYDPAARATPMELLQDKYFTEEPLPVPISAL 
               
               
                   
                   
                 QVPQSKNSHDEDSAGGWYDYNDMDSDSDFEDFGPLKFTPTSTGFSIQFP 
               
               
                   
               
               
                 276 
                 Cyclin A 
                 MSNQHRRSSFSSSTTSSLAKRHASSSSSSLENAGKAFAAAAVPSHLAKKRAPLG 
                 187 
                 1686 
               
               
                   
                   
                 NLTNLKAGDGNSRSSSAPSTLVANATKLAKTRKGSSTSSSIMGLSGSALPRYAS 
               
               
                   
                   
                 TKPSGVLPSVNPSIPRIEIAVDPMSCSMVVSPSRSDMQSVSLDESMSTCESFKS 
               
               
                   
                   
                 PDVEYIDNEDVSAVDSIDRKTFSNLYISDAAAKTAVNICERDVLMEMETDEKIV 
               
               
                   
                   
                 NVDDNYSDPQLCATIACDIYQHLRASEAKKRPSTDFMDRVQKDITASMRAILID 
               
               
                   
                   
                 WLVEVAEEYRLVPDTLYLTVNYIDRYLSGNVMNRQRLQLLGVACMMIAAKYEEI 
               
               
                   
                   
                 CAPQVEEFCYITDNTYFKEEVLQMESSVLNYLKFEMTAPTVKCFLRRFVRAAQG 
               
               
                   
                   
                 VNEVPSLQLECMANYIAELSLLEYDMLCYAPSLVAASAIFLAKFVITPSKRPWD 
               
               
                   
                   
                 PTLQHYTLYQPSDLGNCVKDLHRLCFNNHGSTLPAIREKYSQHKYKYVAKKYCP 
               
               
                   
                   
                 PSIPPEFFHNLVY 
               
               
                   
               
               
                 277 
                 Cyclin A 
                 MNKENAVGTKSEAPTIRITRSRSKALGTSTGMLPSSRPSFKQEQKRTVRANAKR 
                 238 
                 1653 
               
               
                   
                   
                 SASDENKGTMVGNASKQHKKRTVLNDVTNIFCENSYSNCLNAAKAQTSRQGRKW 
               
               
                   
                   
                 SMKKDRDVHQSGAVQIMQEDVQAQFVEESSKIKVAESMEITIPDKWAKRENSEH 
               
               
                   
                   
                 SISMKDTVAESSRKPQEFICGEKSAALVQPSIVDIDSKLEDPQACTPYALDIYN 
               
               
                   
                   
                 YKRSTELERRPSTIYMETLQKDVTPNMRGILVDWLVEVSEEYKLVPDTLYLTVN 
               
               
                   
                   
                 LIDRSLSQKFIEKQRLQLLGVTCMLIASKYEEICPPRVEEFCFITDNTYTSLEV 
               
               
                   
                   
                 LKMESRVLNLLHFQLSVPTVKTFLRRFVQAAQVSSEVPSVELEYLANYLAELTL 
               
               
                   
                   
                 VEYSFLKELPSLMAASAVLLARWTLNQSDNPWNLTLEHYTKYKASELKAAVLAL 
               
               
                   
                   
                 EDLQLNTSGSTLNAIREKYRQQKVNYSLLIHSKANHEIL 
               
               
                   
               
               
                 278 
                 Cyclin B 
                 MAGSDENNPGVVGGAHVQEGLRVGAGKMGAGNVQQRRALSNINSNIIGAPPYPC 
                 235 
                 1539 
               
               
                   
                   
                 AVNKRVLSEKNVNSENDLLNAAHRPITRQFAAQMAYKQQLRPEENKRTTQSVSN 
               
               
                   
                   
                 PSKSEDCAILDVDDDKMADDFPVPMFVQHTEAMLEEIDRMEEVEMEDVAEEPVT 
               
               
                   
                   
                 DIDSGDKENQLAVVEYIDDLYMFYQKAEASSCVPPNYMDRQQDINERMRGILID 
               
               
                   
                   
                 WLIEVHYKFELMDETLYLTVNLIDRFLAVQPVVKKKLQLVGVTAMLLACKYEEV 
               
               
                   
                   
                 SVPVVEDLILISDRAYSRKEVLEMERLMVNTLHFNMSVPTPYVFMRRFLKAAQS 
               
               
                   
                   
                 DKKLELLSFFIIELSLVEYDMLKFPPSLLAASAIYTALSTITRTKQWSTTCEWH 
               
               
                   
                   
                 TSYSEEQLLECARLMVTFHQRAGSGKLTGVHRKYSTSKFGHAARTEPANFLLDF 
               
               
                   
                   
                 RL 
               
               
                   
               
               
                 279 
                 Cyclin B 
                 MASRPIVPVQARGEAAIGGGAGKAAIGGGAGKQQKKNGAAEGRNRKALGDIGNL 
                 158 
                 1618 
               
               
                   
                   
                 VTVRGIEGKVQPHRPITRSFCAQLLANAQAAAAAENNKKQAVVNVNGAPSILDV 
               
               
                   
                   
                 PGAGKRAEPAAAAAAAVAKAAQKKVVKPKQKAEVIDLTSDSERAIEAKKKQQHH 
               
               
                   
                   
                 EPTKKEGEKSSRRNMPTLTSVLTARSKAACGMTKKPKEKVVDIDAGDAHNELAA 
               
               
                   
                   
                 FEYIEDIYTYYKEAENESLPRNYMSSQPEINEKMRAILVDWLIEIHNKFDLMPE 
               
               
                   
                   
                 TLYLTINIIDRFLSVKAVPRRELQLLGMGALFTASKYEEIWAPEVNDLVCIADR 
               
               
                   
                   
                 AYSHEQVLAMEKTILGKLEWTLTVPTHYVFLVRFIKASLGDRKLENMVYFLAEL 
               
               
                   
                   
                 GVMNYATLTYCPSMVAASAVYAARCTLGLTPLWNDTLKLHTGFSESQLMDCARL 
               
               
                   
                   
                 LVGYHAKAKENKLQVVYKKYSSSQREGVALIPPAKALLCEGGGLSSSSSLASSS 
               
               
                   
               
               
                 280 
                 Cyclin B 
                 MGLPDENNAALSKPTNLQVGGLEIGGRKFGQEIRQTRRALSVINQNLVGDRAYP 
                 205 
                 1530 
               
               
                   
                   
                 CHVVNKRGHSKRDAVCGKDQVDPVHRPLTRKFAAQTASTQQHCIEEAKKPRTAV 
               
               
                   
                   
                 QERNEFGDCIFVDVEDCQPSSENQPVPMFLEIPESRLDDDMEEVEMEDIVEEEE 
               
               
                   
                   
                 EEPIMDIDGRDKKNPLAVVDYIEDIYANYRRTENCSCVSANYMAQQADINEKMR 
               
               
                   
                   
                 SILIDWLIEVHDKFDLMHETLFLTVNLIDRFLARQSVVRKKLQLVGLVAMLLAC 
               
               
                   
                   
                 KYEEVSVPVVGDLILISDKAYTRKEVLEMESLMLNSLQFNMSVPTPYVFMRRFL 
               
               
                   
                   
                 KAAESDKKLEVLSFFLIELSLVEYEMVKFPPSLLAAAAIFTAQCTLYGFKQWTK 
               
               
                   
                   
                 TCEWHSNYTEDQLLECARMMVGFHQKAATGKLTGVHRKYGTSKFGYTSKCEPAN 
               
               
                   
                   
                 FLLGEMKNP 
               
               
                   
               
               
                 281 
                 Cyclin B 
                 MGLPDENNAALSKPTNLQVGGLEIGGRKFGQEIRQTRRALSVINQNLVGDRAYP 
                 174 
                 1499 
               
               
                   
                   
                 CHVVNKRGHSKRDAVCGKDQVDPVHRPLTRKFAAQTASTQQHCIEEAKKPRTAV 
               
               
                   
                   
                 QERNEFGDCIFVDVEDCQPSSENQPVPMFLEIPESRLDDDMEEVEMEDIVEEEE 
               
               
                   
                   
                 EEPIMDIDGRDKKNPLAVVDYIEDIYANYRRTENCSCVSANYMAQQADINEKMR 
               
               
                   
                   
                 SILIDWLIEVHDKFDLMHETLFLTVNLIDRFLARQSVVRKKLQLVGLVAMLLAC 
               
               
                   
                   
                 KYEEVSVPVVGDLILISDKAYTRKEVLEMEKLMLNSLQFNMSVPTPYVFMRRFL 
               
               
                   
                   
                 KAAESDKKLEVLSFFLIELSLVEYEMVKFPPSLLAAAAIFTAQCTLYGFKQWTK 
               
               
                   
                   
                 TCEWHSNYTEDQLLECARMMVGFHQKAATGKLTGVHRKYGTSKFGYTSKCEAAN 
               
               
                   
                   
                 FLLGEMKNP 
               
               
                   
               
               
                 282 
                 Cyclin D 
                 MAMVQRQGHDPSSPQEQEDGPSSFLSDDALYCEEGRFEEDDGGGGGQVDGIPLF 
                 94 
                 1332 
               
               
                   
                   
                 PSQPADRQQDSPWADEDGEEKEEEEAELQSLFSKERGARPELAKDDGGAVAARR 
               
               
                   
                   
                 EAVEWMLMVRGVYGFSALTAVLAVDYLDRFLAGFRLQRDNRPWMTQLVAVACLA 
               
               
                   
                   
                 LAAKVEETDVPLLVELQEVGDARYVFEAKTVQRMELLVLSTLGWEMHPVTPLSF 
               
               
                   
                   
                 VHHVARRLGASPHHGEFTHWAFLRRCERLLVAAVSDARSLKHLPSVLAAAAMLR 
               
               
                   
                   
                 VIEEVEPFRSSEYKAQLLSALHMSQEMVEDCCRFILGIAETAGDAVTSSLDSFL 
               
               
                   
                   
                 KRKRRCGHLSPRSPSGVIDASFSCDDESNDSWATDPPSDPDDNDDLNPLPKKSR 
               
               
                   
                   
                 SSSPSSSPSSVPDKVLDLPFMNRIFEGIVNGSPI 
               
               
                   
               
               
                 283 
                 Cyclin D 
                 MEASYQPHHHGHLRQHDPSSSQQEEQVPFDALYCSEEHWGEEDEEEGLASDGLL 
                 176 
                 1342 
               
               
                   
                   
                 SEERDHRLLSPRALLDQDLLWEDEELASLFSKEEPGGMRLNLENDPSLADARRE 
               
               
                   
                   
                 AVEWIMRVHAHYAFSALTALLAVNYWDRFTCSFALQEDKPWMTQLSAVACLSLA 
               
               
                   
                   
                 AKVEETQVPLLIDFQVEDSSPVFEAKNIQRMELLVLSSLEWKMNPVTPLSFLDY 
               
               
                   
                   
                 MTRRLGLTGHLCWEFLRRCENVLLSVISDCRFTCYLPSVIAASTMLHVINGLKP 
               
               
                   
                   
                 RLDVEDQTQLLGILAMGMDKIDACYKLIDDDHALRSQRYSHNKRKFGSVPGSPR 
               
               
                   
                   
                 GVMELCFSSDGSNDSWSVAASVSSSPEPHSKKSRAGEEAEDRLLRGLEGEEDDP 
               
               
                   
                   
                 ASADIFSFPH 
               
               
                   
               
               
                 284 
                 Cyclin D 
                 MALQEEDTRRHYPTAPPFSPDGLYCEDETFGEDLADNACEYAGGGARDGLCEIK 
                 150 
                 1283 
               
               
                   
                   
                 DPTLPPSLLGQDLFWEDGELASLVSRETGTHPCWDELISDGSVALARKDAVGWI 
               
               
                   
                   
                 LRVHGHYGFRPLTAMLAVNYLDRFFLSRSYQRDRPWISQLVAVACLSVAAKVEE 
               
               
                   
                   
                 TQVPILLDLQVANAKFVFESRTIQRMELLLMSTLDWRMNSVTPISFFDHILRRF 
               
               
                   
                   
                 GLTTNLHRQFFWMCERLLLSVVADVRLASFLPSVVATAAMLYVNKEIEPCICSE 
               
               
                   
                   
                 FLDQLLSLLKINEDRVNECYELILELSIDHPEILNYKHKRKRGSVPSSPSGVID 
               
               
                   
                   
                 TSFSCDSSNDSWGVASSVSSSLEPRFKRSRFQDQQMGLPSVNVSSMGVLNSSY 
               
               
                   
               
               
                 285 
                 Cyclin- 
                 MGQIQYSEKYFDDTYEYRHVVLPPDVAKLLPKNRLLSENEWRAIGVQQSRGWVH 
                 101 
                 367 
               
               
                   
                 dependent 
                 YAIHRPEPHIMLFRRPLNYQQQQENQAQQNMLAK 
               
               
                   
                 kinase 
               
               
                   
                 regulatory 
               
               
                   
                 subunit 
               
               
                   
               
               
                 286 
                 Histone 
                 MGSIDPPKAEQNGTAAAAVADPGQKPGAGDAMPPPPPVKHSNGTAAEPDVATKR 
                 9 
                 1352 
               
               
                   
                 acetyltransferase 
                 RRMSVLPLEVGTRVMCRWRDGKYHPVKVIERRKLNPGDPNDYEYYVHYTEFNRR 
               
               
                   
                   
                 LDEWVKLEQLDLNSVETVVDEKVEDKVTGLKMTRHQKRKIDETHVEGHEELDAA 
               
               
                   
                   
                 SLREHEEFTKVKNIATIELGRYEIETWYFSPFPPEYNDCSKLYFCEFCLNFMKR 
               
               
                   
                   
                 KEQLQRHMKKCDLKHPPGDEIYRSGTLSMFEVDGKKNKVYGQNLCYLAKLFLDH 
               
               
                   
                   
                 KTLYYDVDLFLFYVLCECDDRGCHMVGYFSKEKHSEESYNLACILTLPPYQRKG 
               
               
                   
                   
                 YGKFLIAFSYELSKKEGKVGTPERPLSDLGLLSYKGYWTRVLLDILKKHKANIS 
               
               
                   
                   
                 IKELSDMTAIKADDILNTLQSLDLIQYRKGQHVICADPKVLDRHLKAAGRGGLE 
               
               
                   
                   
                 VDVSKLIWTPYREQG 
               
               
                   
               
               
                 287 
                 Histone 
                 MAQKHSTAPDPAAEPKKRRRVGFSGIDAGVDPNGCFKVYLVSREEEVGAPDSFC 
                 89 
                 1486 
               
               
                   
                 acetyltransferase 
                 LDPVDLSHFFEEEDGKIYGYEGLKISVWVSCVSFHSYAEIAFESKSDGGKGITD 
               
               
                   
                   
                 LNTALKNMFGETLVDNKDDFLQTFSKETQFIRSTVSAGEILKHKHSDDHVNDSV 
               
               
                   
                   
                 SNLKVGSDVEAVRMLMGDMTAGHLYSRLVPLVLLLVDGSSPIDVTDSSWELYLL 
               
               
                   
                   
                 IQKTSDQQGNFHDRLLGFAAVYRFYHYPDSSRLRLGQILVLPLYQRKGYGRYLL 
               
               
                   
                   
                 EVLNNVAIADDVYDFTIEEPVDNLQHLRTCIDVQRLLSFDKVQQAVNSTVSQLK 
               
               
                   
                   
                 QGKLSKKTYIPRLLPPPSVVEDARKRFKINKKQFLQCWEILVYLGLDPADKSIQ 
               
               
                   
                   
                 DYFSVISNRVRADILGKDSETAGKKVIEVPSDFDPEMSFVMHRAKAGGEANGIQ 
               
               
                   
                   
                 VEDNQNKQEEQLQQLIDERLKDIKLIAEKVTQK 
               
               
                   
               
               
                 288 
                 Histone 
                 MAQKHSTAPDPAAEPKKRRRVGFSGIDAGVDPNGCFKVYLVSREEEVGAPDSFC 
                 89 
                 1477 
               
               
                   
                 acetyltransferase 
                 LDPVDLSHFFEEEDGKIYGYEGLKISVWVSCVSFHSYAEIAFESKSDGGKGITD 
               
               
                   
                   
                 LNTALKNMFGETLVDNKDDFLQTFSKETQFIRSTVSAGEILKHKHSDGHVNDSV 
               
               
                   
                   
                 SNLKVGSDVEAVRMLMGDMTAGHLYSRLVPLVLLLVDGSNPIDVTDSSWELYLL 
               
               
                   
                   
                 IQKTSDQQGNFHDRLLGFAAVYRFYHYPDSLRLRLGQILVLPLYQRKGYGHYLL 
               
               
                   
                   
                 EVLNNVAIADDVYDFTIEEPVDNLQHLRTCIDVQRLLSFDKVQQAVNSTVSQLK 
               
               
                   
                   
                 QGKLSKKTYIPRLLPPPSVVEDARKRFKINKKQFLQCWEILVYLGLDPADKSIQ 
               
               
                   
                   
                 DYFSVISNRVRADILGKDSETAGKKVIEVPSDFDPEMSFVLHRAKAGGETNGIQ 
               
               
                   
                   
                 VEDNQNKQEEQLQQLIDERLKDIKLIAQKVSRK 
               
               
                   
               
               
                 289 
                 Histone 
                 MALPMEFWGVEVKAGQPLKVNPGNAKILHLSQASLGECKSSKGNESVPLHVKFG 
                 160 
                 1062 
               
               
                   
                 deacetylase 
                 DQKLVLGTLSTENFPQLAFDLVFEKEFELSHNWKSGSVYFCGYKSVVHDDDDEF 
               
               
                   
                   
                 SDLESDSEEEDLPMIGVENGKVAAQASAKTATASANASKVESSGKQKARIPQPM 
               
               
                   
                   
                 KVDEDDSDEDDDDEDEDESDEEGVDGEADSDEEEDESDEEETPKKAEIGKKRAA 
               
               
                   
                   
                 DSATKTPVPAKKSKLPTPQKTDGKKGGHTATPHPAKQAGKNPANSANKSQSPKS 
               
               
                   
                   
                 AGQVSCKSCSKTFNSDGALQSHSKAKHGGK; 
               
               
                   
               
               
                 290 
                 Histone 
                 MEFWGVEVKAGQPLKVNPGNAKILHLSQASLGECKSSKGNESVPLHVKFGDQKL 
                 172 
                 1077 
               
               
                   
                 deacetylase 
                 VLGTLSTENFPQLAFDLVFEKEFELSHNWKSGSVYFCGYKSVVHDDDDEFSDLE 
               
               
                   
                   
                 SDSEEEDLPMIGVENGKVAAQASAKTATASANASKVESSGKQKASIPQPMKVDE 
               
               
                   
                   
                 DDSDEDDDEDDDDEDESDEGVDGEADSDEEEDESDEEETPKKAEIGKKRAADSA 
               
               
                   
                   
                 TKTPVPAKKSKLPTPQKTDGKKGGHTATPHPAKQAGKNPANSANKSQSPKSAGQ 
               
               
                   
                   
                 VSCKSCSKTFNSDGALQSHSKAKHGGK 
               
               
                   
               
               
                 291 
                 Histone 
                 MEFWGVEVKSGEPLNVEPGAETVVHLSQACLGETKEKTKESVLLYVHIGVQKLV 
                 66 
                 989 
               
               
                   
                 deacetylase 
                 LGTLSADKFPQIPFDLVFEKSFKLSHNWKNGSVFFSGYKTLLPCGSDADSPYSD 
               
               
                   
                   
                 SDTDEGLPINVTAQADVPAKKAPVTANANAAKPNLASAKQKVKIVESNEDGKNE 
               
               
                   
                   
                 GDDDEDADVSSDDDAEDDSGDEDMVDGGDESSDEDDDDSEEGESSEEEEPKAQP 
               
               
                   
                   
                 SKKRPADSVLKTPASDKKSKLETPQKTDGKKASEHVATPYPSKQAGKAIASKGQ 
               
               
                   
                   
                 AKQQTPNSNEFSCKPCNRSFKSDQALQSHNKAKHGGS 
               
               
                   
               
               
                 292 
                 Histone 
                 MDTGGNSLPSGPDGVKRKVCYFYDPEVGNYYLLQHMQVLKPVPARDRDLCRFHA 
                 111 
                 1541 
               
               
                   
                 deacetylase 
                 DDYVAFLRSITPETQQDQLRQLKRFNVGEDCPVFDGLHSFCQTYAGGSVGGAVK 
               
               
                   
                   
                 LNHGLCDIAINWAGGLHHAKKCEASGFCYVNDIVLGILELLKQHERVLYVDIDI 
               
               
                   
                   
                 HHGDGVEEAFYTTDRVMTVSFHKFGDYFPGTGDIRDIGYGKGKYYSLNVPLDDG 
               
               
                   
                   
                 IDDESYHSLFKPIIGKVMEVFKPGAVVLQCGADSLSGDRLGCFNLSIKGHAECV 
               
               
                   
                   
                 RYMRSFNVPVLLLGGGGYTIRNVARCWCYETGVALGLEVDDKMPQHEYYEYFGP 
               
               
                   
                   
                 DYTLHVAPSNMENKNSRQLLEEIRSKLLENLSKLQHAPSVPFQERPPDTELPEA 
               
               
                   
                   
                 DEDQEDPDERWDPDSDMDVDEDRKPLPSRVKRELIVEPEVKDQDSQKASIDHGR 
               
               
                   
                   
                 GLDTTQEDNASIKVSDMNSMITDEQSVKMEQDNVNKPSEQIFPK 
               
               
                   
               
               
                 293 
                 Histone 
                 MDTGGNSLPSGPDGVKRKVCYFYDPEVGNYYYGQGHPMKPHRIRMTHALLAHYG 
                 116 
                 1615 
               
               
                   
                 deacetylase 
                 LLQHMQVLKPVPARDRDLCRFHADDYVAFLRSITPETQQDQLRQLKRFNVGEDC 
               
               
                   
                   
                 PVFDGLHSFCQTYAGGSVGGAVKLNHGLCDIAINWAGGLHHAKKCEASGFCYVN 
               
               
                   
                   
                 DIVLGILELLKQHERVLYVDIDIHHGDGVEEAFYTTDRVMTVSFHKFGDYFPGT 
               
               
                   
                   
                 GDIRDIGYGKGKYYSLNVPLDDGIDDESYHSLFKPIIGKVMEVFKPGAVVLQCG 
               
               
                   
                   
                 ADSLSGDRLGCFNLSIKGHAECVRYMRSFNVPVLLLGGGGYTIRNVARCWCYET 
               
               
                   
                   
                 GVALGLEVDDKMPQHEYYEYFGPDYTLHVAPSNMENKNSRQLLEDIRSKLLENL 
               
               
                   
                   
                 SKLQHAPSVPFQERPPDTELPEADEDQEDPDERWDPDSDMDVDEDRKPLPSRVK 
               
               
                   
                   
                 RELIVEPEVKDQDSQKASIDHGRGLDTTQEDNASIKVSDMNSMITDEQSVKMEQ 
               
               
                   
                   
                 DNVNKPSEQIFPK 
               
               
                   
               
               
                 294 
                 Histone 
                 MRPKDRISYFYDGDVGSVYFGPNHPMKPHRLCMTHHLVLSYELHTKMEIYRPHK 
                 155 
                 1453 
               
               
                   
                 deacetylase 
                 AYPAELAQFHSPDYVEFLHRITPDTQHLFPNDLAKYNLGEDCPVFENLFEFCQI 
               
               
                   
                   
                 YAGGTIDAARRLNNQLCDIAINWAGGLHHAKKCEASGFCYINDLVLGILELLKY 
               
               
                   
                   
                 HARVLYIDIDVHHGDGVEEAFYFTDRVMTVSFHKFGDMFFPGTGDVKEIGGKEG 
               
               
                   
                   
                 KFYAINVPLKDGIDDTSFTRLFKAIISKVVETYQPGAIVLQCGADSLAGDRLGC 
               
               
                   
                   
                 FNLSIDGHSECVRFVKKFNLPLLVTGGGGYTKENVARCWVVETGVLLDTELPNE 
               
               
                   
                   
                 IPENEYFKYFAPDYSLKIPRGNIVLENLNSKSYLSAIKVQVLENLENIQHAPSV 
               
               
                   
                   
                 QMQEVPPDFYIPDFDEDEQNPDERMDQHTQDKQIQRDDEYYDGDNDNDHNMDDS 
               
               
                   
               
               
                 295 
                 Histone 
                 MTVAEDFHVNNRSKMVSQATPESRLTGGEDDNSLHNQVDELLCQELPERQVILE 
                 228 
                 2033 
               
               
                   
                 deacetylase 
                 FEGTRPKPYFSDHNGGENSALGVRATEDDLNSDVEAEEKQKEMITLEDMYKNDGT 
               
               
                   
                   
                 LYDDDEDDSDWEPVKRQVELMRWFCTNCTMVNVEDVFLCDICGEHRDSGILRHG 
               
               
                   
                   
                 FYASPFMQDVGAPSVEAEVQESREDHARSSPPSSSTVVGFDEKMLLHSEVEMKS 
               
               
                   
                   
                 HPHPERADRLQAIAASLATAGIFPGRCRSLPVREITKEELQMVHSSEHVDAVEM 
               
               
                   
                   
                 TSHMFSSYFTPDTYANEHSARAARIAAGLCADLASTIISGRSKNGFALVRPPGH 
               
               
                   
                   
                 HAGIKHAMGFCLHNNAAVAALAAQGAGAKKVLIVDWDVHHGNGTQEIFDGNKSV 
               
               
                   
                   
                 LYISLHRHEGGNFYPGTGAAHEVGTMGAEGYCVNIPWSRRGVGDNDYVFAFHHI 
               
               
                   
                   
                 VLPIASAFAPDFTIISAGFDAARGDPLGCCDVTPAGYAQMTHMLSALSGGKLLV 
               
               
                   
                   
                 ILEGGYNLRSISSSAVAVIKVLLGDSPISEIADAVPSKAGLRTVLEVLKIQRSY 
               
               
                   
                   
                 WPSLESIFWELQSQWGIFLVDNRRKQIRKRRRVLVPIWWKWGRKSVLYHLLNGH 
               
               
                   
                   
                 LHVKTKR 
               
               
                   
               
               
                 296 
                 Histone 
                 MAAAPSSPPTNRVDVFWHDGMLSHDTGRGVFDTGSDPGFLDVLEKHPENPDRVR 
                 110 
                 1258 
               
               
                   
                 deacetylase 
                 NMVSILKRGPISPFISWHTATPALISQLLSFHSPEYINELVEADKNGGKVLCAG 
               
               
                   
                   
                 TFLNPGSWDAALLAAGNTLSAMKYVLDGKGKIAYALVRPPGHHAQPSQADGYCF 
               
               
                   
                   
                 LNNAGLAVRLALDSGCKRVVVVDIDVHYGNGTAEGFYQSSDVLTISLHMNHGSW 
               
               
                   
                   
                 GPSHPQSGSVDELGEDEGYGYNMNIPLPNGTGDRGYEYAVTELVVPAVESFKPE 
               
               
                   
                   
                 MVVLVVGQDSSAFDPNGRQCLTMDGYRAIGRTIRGLADRHSGGRILIVQEGGYH 
               
               
                   
                   
                 VTYSAYCLHATVEGILDLPDPLLADPIAYYPEDEAFPVKVVDSIKRYLVDKVPF 
               
               
                   
                   
                 LKEH 
               
               
                   
               
               
                 297 
                 Histone 
                 MVESSGGASLPSVGQDARKRRVSYFYEPTIGDYYYGQGHPMKPHRIRMAHNLIV 
                 50 
                 1462 
               
               
                   
                 deacetylase 
                 HYYLHRRMEISRPFPAATTDIRRFHSEDYVTFISSVTPETVSDPAFSRQLKRFN 
               
               
                   
                   
                 VGEDCPVFDGIFGFCQASAGGSMGAAVKLNRGDSDIALNWAGGLHHAKKSEASG 
               
               
                   
                   
                 FCYVNDIVLGILELLKVHKRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKFGD 
               
               
                   
                   
                 FFPGSGHIKDTGAGPGKNYALNVPLNDGIDDESFRGMFRPIIQKVMEVYQPDAV 
               
               
                   
                   
                 VLQCGADSLSGDRLGCFNLSVKGHADCLRFLRSFNVPLMVLGGGGYTMRNVARC 
               
               
                   
                   
                 WCYETAVAVGVEPENDLPYNEYYEYFGPDYTLHVEPCSMENLNAPKDLERIRNM 
               
               
                   
                   
                 LLEQLSRIPHAPSVPFQMTPPITQEPEEAEEDMDERPKPRIWNGEDYESDAEED 
               
               
                   
                   
                 KSQHRSSNADALHDENVEMRDSVGENSGDKTREDRSPS 
               
               
                   
               
               
                 298 
                 MAT1 CDK- 
                 MVVPSSNPHNREMAIRRRMASTFNKREDDFPSLREYNDYLEEVEEMTFNLIEGV 
                 176 
                 739 
               
               
                   
                 activating 
                 DVPTIEAKIAKYQEENAEQIMINRAKKAEEFAAALAASKGLPPQTDPDGALNSQ 
               
               
                   
                 kinase assembly 
                 AGLSVGTQGQYAPAIAGGQPRPTGMAPQPVPLGTGLDTHGYDDEEMIKLRAERG 
               
               
                   
                 factor 
                 GRAGGWSIELSKKRALEEAFGSLWL 
               
               
                   
               
               
                 299 
                 Peptidylprolyl 
                 MAAIISCHHYHSCCSSLIASKWVGARIPTSCFGRSSTQSNNAASVRQFVTRCSS 
                 150 
                 1529 
               
               
                   
                 isomerase 
                 SPSSRGQWQPHQNGEKGRSFSLRECAISIALAVGLVTGVPSLDMSTGNAYAASP 
               
               
                   
                   
                 ALPDLSVLISGPPIKDPEALLRYALPINNKAIREVQKPLEDITDSLKVAGLRAL 
               
               
                   
                   
                 DSVERNVRQASRVLKQGKNLIVSGLAESKKDHGVELLDKLEAGMDELQQIVEDG 
               
               
                   
                   
                 NRDAVAGKQRELLNYVGGVEEDMVDGFPYEVPEEYKNMPLLKGRAAVDMKVKVK 
               
               
                   
                   
                 DNPNLEECVFRIVLDGYNAPVTAGNFVDLVERHFYDGMEIQRADGFVVQTGDPE 
               
               
                   
                   
                 GPAESFIDPSTEKPRTIPLEIMVDGEKAPVYGATLEELGLYKAQTKLPFNAFGT 
               
               
                   
                   
                 MAMARDEFEDNSASSQIFWLLKESELTPSNANILDGRYAVFGYVTENQDFLADL 
               
               
                   
                   
                 KVGDVIESVQVVSGLDNLANPSYKIAG; 
               
               
                   
               
               
                 300 
                 Peptidylprolyl 
                 MAGEDFDIPPADEMNEDFDLPDDDDDAPVMKAGDEKEIGKQGLKKKLVKEGDAW 
                 247 
                 1971 
               
               
                   
                 isomerase 
                 ETPDNGDEVEVHYTGTLLDGTQFDSSRDRGTPFKFTLGQGQVIKGWDQGIKTMK 
               
               
                   
                   
                 KGENAIFTIPPELAYGEAGSPPTIPPNATLQFDVELLSWTSVKDICKDGGIFKK 
               
               
                   
                   
                 ILVEGEKWENPKDLDEVLVKYEFQLEDGTTIARSDGVEFTVKEGHFCPAVAKAV 
               
               
                   
                   
                 KTMKKGEKVLLTVKPQYGFGEKGKPASGDEGAVPPNATLQITLELVSWKTVSEV 
               
               
                   
                   
                 TDDKKVIKKILKEGEGYERPNEGAVVEVKLIGKLQDGTVFVKKGHDDCEELFKF 
               
               
                   
                   
                 KIDEEQVVDGLDKAVMNMKKGEVALLTVAPEYAFGSSESKQDLAVVPPSSTVYY 
               
               
                   
                   
                 EVELVSFVKDKESWDMNTEEKIEAAGKKKEEGNVIFKAGKYAKASKRYEKAVKY 
               
               
                   
                   
                 IEYDTSFSEDEKKQAKALKVACNLNDAACKLKLKDYNQAEKLCTKVLELDSRNV 
               
               
                   
                   
                 KALYRRAQAYIELSDLDLAEFDIKKALEIDPHNRDVKLEYKVLKEKVKEFNKKD 
               
               
                   
                   
                 AKFYGNMFAKMSKLEPVEKTAAKEPEPMSIDSKA; 
               
               
                   
               
               
                 301 
                 Peptidylprolyl 
                 MSTVYVLEPPTKGKVVLNTTHGPLDVELWPKEAPKAVRNFVQLCLEGYYDNTIF 
                 136 
                 1644 
               
               
                   
                 isomerase 
                 HRIIKDFLVQGGDPTGSGTGGESIYGDAFSDEFHSRLRFKHRGLVACANAGSPH 
               
               
                   
                   
                 SNGSQFFITLDRCDWLDRKNTIFGKITGDSIYNLSGLAEVETDKSDRPLDPPPK 
               
               
                   
                   
                 IISVEVLWNPFEDIVPRAPVRSLVPTVPDVQNKEPKKKAVKKLNLLSFGEEAEE 
               
               
                   
                   
                 EEKALVVVKQKIKSSHDVLDDPRLLKEHIPSKQVDSYDSKTARDVQSVREALSS 
               
               
                   
                   
                 KKQELQKESGAEFSNSFREIADDEDDDDDDASFDARMRRQILQKRKELGDLPPK 
               
               
                   
                   
                 PKPKSRDGISARKERETSISRDKDDDDDDDQPRVEKLSLKKKGIGSEARGERMA 
               
               
                   
                   
                 NADADLQLLNDAERGRQLQKQKKHRLRGREDEVLTKLETFKASVFGKPLASSAK 
               
               
                   
                   
                 VGDGDGDLSDWRSVKLKFAPEPGKDRMTRNEDPNDYVVVDPLLEKGKEKFNRMQ 
               
               
                   
                   
                 AKEKRRGREWAGKSLT; 
               
               
                   
               
               
                 302 
                 Peptidylprolyl 
                 MASAISMHSSGLLLLQGTNGKDVTEMGKAPASSRVANMQQRKYGATCCVARGLT 
                 48 
                 836 
               
               
                   
                 isomerase 
                 SRSHYASSLAFKQFSKTPSIKYDRMVEIKAMATDLGLQAKVTNKCFFDVEIGGE 
               
               
                   
                   
                 PAGRIVIGLFGDDVPKTVENFRALCTGEKGFGYKGCSFHRIIKDFMIQGGDFTR 
               
               
                   
                   
                 GNGTGGKSIYGSTFEDENFALKHVGPGVLSMANAGPSTNGSQFFICTVKTPWLD 
               
               
                   
                   
                 NRHVVFGQVVDGMDVVQKLESQETSRSDVPRQPCRIVNCGELPLDG; 
               
               
                   
               
               
                 303 
                 Peptidylprolyl 
                 MAASFTALSNVGSLSSPRNGSEIRRFRPSCNVAASVRPPPLKAGLSASSSSSFS 
                 49 
                 822 
               
               
                   
                 isomerase 
                 GSLRLIPLSSSPQRKSRPCSVRASAEAAAAQSKVTNKVYLDISIGNPVGKLVGR 
               
               
                   
                   
                 IVIGLYGDDVPQTAENFRALCTGEKGFGYKGSTVHRVIKDFMIQGGDFDKGNGT 
               
               
                   
                   
                 GGKSIYGRTFKDENFKLSHVGPGVVSMANAGPNTNGSQFFICTVKTPWLDQRHV 
               
               
                   
                   
                 VFGQVLEGMDIVRLIESQETDRGDRPRKRVVVSDCGELPVV; 
               
               
                   
               
               
                 304 
                 Peptidylprolyl 
                 MAEAIDLTGDGGVMKTIVRRAKPDAVSPSETLPLVDVRYEGVLAETGEVFDSTH 
                 185 
                 751 
               
               
                   
                 isomerase 
                 EDNTLFSFEIGKGSVISAWDTALRTMKVGEVAKITCKPEYAYGSTGSPPDIPPD 
               
               
                   
                   
                 ATLIFEVELVACKPCKGFSVTSVTEDKARLEELKKQREIAAATKEEEKKRREEA 
               
               
                   
                   
                 KAAAAARVQAKLDAKKGHGKGKGKAK; 
               
               
                   
               
               
                 305 
                 Peptidylprolyl 
                 MGNPKVFFDMSIGGQPAGRIVMELYADVVPRTAENFRALCTGEKGAGRSGKPLH 
                 103 
                 621 
               
               
                   
                 isomerase 
                 YKGSSFHRVIPGFMCQGGDFTAGNGTGGESIYGSKFADENFVKKHTGPGVLSMA 
               
               
                   
                   
                 NAGPGTNGSQFFVCTAKTEWLDGKHVVFGQIVDGMDVVKAIEKVGSSSGRTSKP 
               
               
                   
                   
                 VVVADCGQLS 
               
               
                   
               
               
                 306 
                 Peptidylprolyl 
                 MPNPKVFFDMTIGGAAAGRVVMELYADTTPRTAENFRALCTGEKGVGRSKKPLH 
                 41 
                 559 
               
               
                   
                 isomerase 
                 YKGSKFHRVIPSFMCQGGDFTAGNGTGGESIYGVKFADENFIKKHTGPGILSMA 
               
               
                   
                   
                 NAGPGTNGSQFFICTTKTEWLDGKHVVFGKVVEGMEVVKAIEKVGSSSGRTSKP 
               
               
                   
                   
                 VVVADCGQLP 
               
               
                   
               
               
                 307 
                 Peptidylprolyl 
                 MAEAIDLTGDGGVMKTIVRRAKPDAVSPSETLPLVDVRYEGVLAETGEVFDSTH 
                 127 
                 693 
               
               
                   
                 isomerase 
                 EDNTLFSFEIGKGSVISAWDTALRTMKVGEVAKITCKPEYAYGSTGSPPDIPPD 
               
               
                   
                   
                 ATLIFEVELVACKPCKGFSVTSVTEDKARLEELKKQREIAAATKEEEKKRREEA 
               
               
                   
                   
                 KAAAAARVQAKLDAKKGHGKGKGKAK 
               
               
                   
               
               
                 308 
                 Peptidylprolyl 
                 MATARSFFLCALLLLATLYLAQAKKSEDLKEVTHKVYFDVEIAGKPAGRIVMGL 
                 28 
                 639 
               
               
                   
                 isomerase 
                 YGKAVPKTAENFRALCTGEKGTGKSGKPLHYKGSSFHRIIPSFMLQGGDFTLGD 
               
               
                   
                   
                 GRGGESIYGEKFADENFKLKHTGPGLLSMANAGPDTNGSQFFITTVTTSWLDGR 
               
               
                   
                   
                 HVVFGKVLSGMDVVYKVEAEGRQSGTPKSKVVIADSGELPL 
               
               
                   
               
               
                 309 
                 Peptidylprolyl 
                 MMRREISVLLQPRFVLAFLALAVLLLVFAFPFSRQRGDQVEEEPEITHRVYLDV 
                 135 
                 812 
               
               
                   
                 isomerase 
                 DIDGQHLGRIVIGLYGEVVPRTVENFRALCTGEKGKSANGKKLHYKGTPFHRII 
               
               
                   
                   
                 SGFMIQGGDVIYGDGKGYESIYGGTFADENFRIKHSHAGIISMVNSGPDSNGSQ 
               
               
                   
                   
                 FFITTVKASWLDGEHVVFGRVIQGMDTVYAIEGGAGTYNGKPRKKVIIADSGEI 
               
               
                   
                   
                 PKSKWDEER 
               
               
                   
               
               
                 310 
                 Peptidylprolyl 
                 MWATAEGGPPEVTLETSMGSFTVELYFKHAPRTSRNFIELSRRGYYDNVKFHRI 
                 119 
                 613 
               
               
                   
                 isomerase 
                 IKDFIVQGGDPTGTGRGGESIYGKKFEDEIKPELKHTGAGILSMANAGPNTNGS 
               
               
                   
                   
                 QFFITLAPCPSLDGKHTIFGRVCRGMEIIKRLGSVQTDNNDRPIHDVKILRTSV 
               
               
                   
                   
                 KD 
               
               
                   
               
               
                 311 
                 Peptidylprolyl 
                 MSNPKVFFDILIGKMKAGRVVMELFADVTPKTAENFRALCTGEKGIGRSGKPLH 
                 38 
                 562 
               
               
                   
                 isomerase 
                 YKGSTFHRIIPNFMCQGGDFTRGNGTGGESIYGMKFADENFKIKHTGLGVLSMA 
               
               
                   
                   
                 NAGPDTNGSQFFICTEKTPWLDGKHVVFGKVIDGYNVVKEMESVGSDSGSTRET 
               
               
                   
                   
                 VAIEDCGQLSEN 
               
               
                   
               
               
                 312 
                 Peptidylprolyl 
                 MDDDFEFPASSNVENDDDDGMDMDDMGGDVPEEEDPVASPAVLKVGEEREIGKA 
                 109 
                 1872 
               
               
                   
                 isomerase 
                 GFKKKLVKEGEGWETPSSGDEVEVHYTGTLLDGTKFDSSRDRGTPFKFKLGRGQ 
               
               
                   
                   
                 VIKGWDEGIKTMKKGENAIFTIPPELAYGESGSPPTIPPNATLQFDVELLSWSS 
               
               
                   
                   
                 VKDICKDGGILKKVLVEGEKWDNPKDLDEVFVKYEASLEDGTLISKSDGVEFTV 
               
               
                   
                   
                 GDGYFCAALAKAVKTMKKGEKVLLTVMPQYAFGETGRPASGDEAAVPPDASLQI 
               
               
                   
                   
                 MLELVSWKTVSDVTKDKKVLKKTLKEGEGYERPNDGAAVQVRLCGKLQDGTVFV 
               
               
                   
                   
                 KKDDEEPFEFKIDEEQVIDGLDRAVKNMKKGEVALVTIQPEYAFGPTESQQDLA 
               
               
                   
                   
                 VVPANSTVYYEVELLSFVKEKESWEMNNQEKIEAAARKKEEGNAAFKAGKYVRA 
               
               
                   
                   
                 SKRYEKAVRFIEYDSSFSDEEKQQAKTLKNTCNLNDAACKLKLKDFKEAEKLCT 
               
               
                   
                   
                 KVLEGDGKNVKALYRRAQAYIQLVDLDLAEQDIKKALEIDPNNRDVKLEYKILK 
               
               
                   
                   
                 EKVREYNKRDAQFYGNMFAKMNKLEHSRTAGMGAKHEAAPMTIDSKA 
               
               
                   
               
               
                 313 
                 Peptidylprolyl 
                 MAKPRCFMDISIGGELEGRIVGELYTDVAPKTAENFRALCTGEKGIGPHTGAPL 
                 74 
                 1159 
               
               
                   
                 isomerase 
                 HYKGVRFHRVIKGFMVQGGDISAGDGTGGESIYGLKFEDENFDLKHERKGMLSM 
               
               
                   
                   
                 ANSGPNTNGSQFFITTTRTSHLDGKHVVFGRVVKGMGVVRSVEHVTTAAGDCPT 
               
               
                   
                   
                 VDVVIADCGEIPAGADDGIRNFFKDGDTYPDWPADLDESPAELSWWMDAVDSIK 
               
               
                   
                   
                 AFGNGSYKKQDYKMALRKYRKALRYLDICWEKEGIDEVESSSLRKTKSQIFTNS 
               
               
                   
                   
                 SACKLKLCDLKGALLDAEFAVRDGENNAKAYFRQGQAHMELNDIDAAAESFSKA 
               
               
                   
                   
                 LELEPNDVGIKKELNAAKKKIFERREQEKRAYRKMFL 
               
               
                   
               
               
                 314 
                 Peptidylprolyl 
                 MTKRKNPLVFLDVSIDGDPVERIVIELFADTVPRTAENFRSLCTGEKGVGKTTG 
                 54 
                 2045 
               
               
                   
                 isomerase 
                 KPLHYKGSYFHRIIKGFMAQGGDFSNGNGTGGESIYGGKFADENFKLAHDGPGL 
               
               
                   
                   
                 LSMANGGPNTNGSQFFIIFKRQPHLDGKHVVFGKVMRGMEVVKKIEQVGSANGK 
               
               
                   
                   
                 PLQPVKIVDCGETSETGTQDAVVEEKSKSATLKAKKKRSARDSSSESRGKRRQR 
               
               
                   
                   
                 KSRKERTRKRRRYSSSDSYSSESSDSDSESYSSDTESESKSHSESSVSDSSSSD 
               
               
                   
                   
                 GRRRKRKSTKREKLRRQRGKDSRGEQKSARYDKKSRHKSADSSSDSESESSSRS 
               
               
                   
                   
                 RSRDDKKKSSRRESARSVSKLKDAEANSPENLESPRDREIKKVEDNSSHEEGEF 
               
               
                   
                   
                 SPKNDVQHNGHGTDAKFGKYDDQRPRSDGSKKSSGSMRDSPKRLANSVPQGSPS 
               
               
                   
                   
                 SSPAHKASEPSSSIRARNPSRSPAPDGNSKRIRKGRGFTERFSYARRYRTPSPE 
               
               
                   
                   
                 DVTYRPYHYGRRNFHDRRNDRYSNYRSYSERSPHRRYRSPPRGRSPPRYQRRRS 
               
               
                   
                   
                 RSRSVSRSPGGNKGRYRGRDQSRSRSRSRSRSPRRGSSPANKQLPLSERLKSRL 
               
               
                   
                   
                 GTRVDEHSPRRRRSSSRSHDSSRSRSPDEVPDKHEGKAAPVSPARSRSSSPSGR 
               
               
                   
                   
                 GLVSYGDASPDSGIN 
               
               
                   
               
               
                 315 
                 Peptidylprolyl 
                 MSVLLVTSLGDIVVDLHADRCPLTCKNFLKLCRIKYYNGCVFHTVQKDFTAQTG 
                 53 
                 1879 
               
               
                   
                 isomerase 
                 DPTGTGTGGDSVYKFLYGDQARFFMDEIHLDLKHSKTGTVAMASGGENLNASQF 
               
               
                   
                   
                 YFTLRDDLDYLDGKHTVFGEVAEGLETLTRINEAYVDEKGRPYKNIRIRHTYIL 
               
               
                   
                   
                 DDPFDDPPQLAELIPDASPEGKPKDEVVDDVRLEDDWVPLDEQLGPAQLEEAIR 
               
               
                   
                   
                 AKEAHSRAVVLESIGDIPDAEIKPPDNVLFVCKLNPVTEDEDLHTIFSRFGTVV 
               
               
                   
                   
                 SADVIRDFKTGDSLCYAFIEFENKDSCEQAYFKMDNALIDDRRIKVDFSQSVAK 
               
               
                   
                   
                 LWSQFKRKDSQAAKGKGCFKCGAPDHMARECPGSSTRQPLSKYILKEDNAQRGG 
               
               
                   
                   
                 DDSRYEMVFDEDAPESPSHGKKRRGRDDRDDRHKMSRQSVEETKFNDREGGHSV 
               
               
                   
                   
                 DKHRQSERSKHREDEMSRDSKASEAGRRRIDRDFPEEERDGEKYTESHRDRDGK 
               
               
                   
                   
                 RGDYRDYRKGEADVQTHGDRRGDENYRRKSAAYDDGHEGAGAARRKDSNDDHHA 
               
               
                   
                   
                 YRRGYGDSRKGTRDEDDDGRGRRDDPSYRRSSGHKDSSNGGREEQKYRSGETDG 
               
               
                   
                   
                 KSHPERSHRGDRRR 
               
               
                   
               
               
                 316 
                 Peptidylprolyl 
                 MRPFNGGSSIACLVLVIAAGALAESQGPHLGSARVVFQTNYGDIEFGFFPGVAP 
                 7 
                 690 
               
               
                   
                 isomerase 
                 RTVDHIFKLVRLGCYNTNHFFRVDKGFVAQVADVANGRTAPMNDEQRTEAEKTI 
               
               
                   
                   
                 VGEFSNVKHVRGILSMGRYDDPDSAQSSFSILLGDAPHLDGKYAIFGRVTKGDE 
               
               
                   
                   
                 TLKKLEQLPTRREGMFVMPTERITILSSYYYDTGAESCEEENSTLRRRLAASAV 
               
               
                   
                   
                 EVERQRMKCFP 
               
               
                   
               
               
                 317 
                 Peptidylprolyl 
                 MPNPKVFFDMQVGGAPAGRIVMELYADVVPKTAENFRALCTGEKGTGRSGKPLH 
                 83 
                 601 
               
               
                   
                 isomerase 
                 FKGSSFHRVIPGFMCQGGDFTRGNGTGGESIYGEKFADENFVKKHTGPGILSMA 
               
               
                   
                   
                 NAGPNTNGSQFFICTAQTSWLDGKHVVFGQVVEGLEVVRDIEKVGSGSGRTSKP 
               
               
                   
                   
                 VVIADSGQLA 
               
               
                   
               
               
                 318 
                 Peptidylprolyl 
                 MRFTSITSAIALFAAAASALDKPLDIKVDKAVECSRKTKAGDKIQVHYRGTLEA 
                 125 
                 535 
               
               
                   
                 isomerase 
                 DGSEFDASYKRGQPLSFHVGKGQVIKGWDQGLLDMCPGEKRTLTIQPDWGYGSR 
               
               
                   
                   
                 GMGPIPANSVLIFETELVEIAGVAREEL 
               
               
                   
               
               
                 319 
                 Peptidylprolyl 
                 MGNPKVFFDMSIGGQPAGRIVMELYADVVPRTAENFRALCTGEKGAGRSGKPLH 
                 55 
                 573 
               
               
                   
                 isomerase 
                 YKGSSFHRVIPGFMCQGGDFTAGNGTGGESIYGSKFADENFVKKHTGPGVLSMA 
               
               
                   
                   
                 NAGPGTNGSQFFVCTAKTEWLDGKHVVFGQIVDGMDVVKAIEKVGSSSGRTSKP 
               
               
                   
                   
                 VVVADCGQLS 
               
               
                   
               
               
                 320 
                 Peptidylprolyl 
                 MAVATRSRWVAMSVAWILVLFGTLALIQNRLSDTGASSDPKLVHRKVGEEKKKP 
                 147 
                 842 
               
               
                   
                 isomerase 
                 DDLEEVTHKVFFDVEIGGKPAGRIVMGLFGKTVPKTVENFRALCTGEKGIGKSG 
               
               
                   
                   
                 KPLNYKGSQFHRIIPKFMIQGGDFTLGDGRGGESIYGNKFSDENFKLKHTDAGR 
               
               
                   
                   
                 LSMTNAGPDTNGSQFFITTVTTSWLDGRHVVFGKVLSGMDVVHKIEAEGGQSGQ 
               
               
                   
                   
                 PKSIVVISDSGELDL 
               
               
                   
               
               
                 321 
                 Peptidylprolyl 
                 MAVTLHTNLGDIKCEIFCDEVPKAAEHNARGILSMANSGPNTNGSQFFIAYAKQ 
                 167 
                 487 
               
               
                   
                 isomerase 
                 PHLNGLYTIFGRVIHGFEVLDIMEKTQTGPGDRPLAEIRLNRVTIHANPLAG 
               
               
                   
               
               
                 322 
                 Peptidylprolyl 
                 MAVATRSRWVAMSVAWILVLFGTLALIQNRLSDTGASSDPKLVHRKVGEEKKKP 
                 195 
                 890 
               
               
                   
                 isomerase 
                 DDLEEVTHKVFFDVEIGGKPAGRIVMGLFGKTVPKTVENFRALCTGEKGIGKSG 
               
               
                   
                   
                 KPLNYKGSQFHRIIPKFMIQGGDFTLGDGRGGESIYGNKFSDENFKLKHTDAGR 
               
               
                   
                   
                 LSMANAGPDTNGSQFFITTVTTSWLDGRHVVFGKVLSGMDVVHKIEAEGGQSGQ 
               
               
                   
                   
                 PKSIVVISDSGELDL 
               
               
                   
               
               
                 323 
                 Peptidylprolyl 
                 MGNPKVFFDMSIGGQPAGRIVMELYADVVPRTAENFRALCTGEKGAGRSGKPLH 
                 68 
                 586 
               
               
                   
                 isomerase 
                 YKGSSFHRVIPGFMCQGGDFTAGNGTGGESIYGSKFADENFVKKHTGPGVLSMA 
               
               
                   
                   
                 NAGPGTNGSQFFVCTAKTEWLDGKHVVFGQIVDGMDVVKAIEKVGSSSGRTSKP 
               
               
                   
                   
                 VVVADCGQLS 
               
               
                   
               
               
                 324 
                 Retinoblastoma 
                 MSPVAANAMEEAAEPEVPAPVTPSKDDADTDAAVSRFLGFCKSKLGLAEGNCVQ 
                 182 
                 3265 
               
               
                   
                 related protein 
                 SSTLLRKTAHVLRSSGTVIGTGTAEEAERYWFAFVLYTVRRVGERKAEDEQNGS 
               
               
                   
                   
                 DETEVPLSRILKASVLNLIDFFKEIPQFVIKAGAIVSGIYGANWDSRLEAREMQ 
               
               
                   
                   
                 TNYVHLCILCKFYKRICGEFFILNDAKDDMKSADSSTSDPVIMYQPFGWLLFLA 
               
               
                   
                   
                 LRIHALSRFKDLVSSTNALVSVLAILIIHLPTRFRKFSISDSSQLVKRSEKGVD 
               
               
                   
                   
                 LVGSLAYRYDTSEDEIKRTLEKANNVIAEILGITPPPASECKAENLENVDTDGL 
               
               
                   
                   
                 IYFGNLMEETSLSSILSTLEKIYEDATRNDSEFDERVFINDDDSLLVSGSLSGA 
               
               
                   
                   
                 AINLTGAKRKYDSFASPAKTITRPLSPSRSPASHINGIIGGTNLRITATPVATA 
               
               
                   
                   
                 MTTAKWLRTFVSPLPSKPSTDLQGFLASCDRDVTSDVIRRANIILEAIFPNSPI 
               
               
                   
                   
                 GERTVTGGLQNANLMDNMWAEQRRLEALKLYYRVLEAMCRAEAQILHSNNLTSL 
               
               
                   
                   
                 LTNERFHRCMLACSAELVLATHKTVTMLFPAVLERTGITAFDLSKVIESFVRHE 
               
               
                   
                   
                 ETLPRELRRHLNTLEERLLENMVWERGSSMYNSLVVARPALAPEINRLGLLPEP 
               
               
                   
                   
                 MPSLDAIALLINFSSSGLPQSPVQKHEASPGQNGDIRSPKRISTEYRSVLVERN 
               
               
                   
                   
                 FTSPVKDRLLALSNIKSKLPPPPLQSAFASPTRPHPGGGGETCAETAIHIFFSK 
               
               
                   
                   
                 ITKLAAVRINAMLERLQLSQQIKEGVYCLFQQILSQRTNLFFNRHIDQVILCCF 
               
               
                   
                   
                 YGVAKINQINLTFREIIYNYRKQPQCKPQVFRNVFVDWSTRRNGKAGNEHVDII 
               
               
                   
                   
                 SFYNEIFIPSVKPLLVELGPTGATTRTNRTSEVGNKNDAQCPGSPKISSFPTLP 
               
               
                   
                   
                 DMSPKKVSASHNVYVSPLRSSKMDASISHSSKSYYACVGESTHAYQSPSKDLVA 
               
               
                   
                   
                 INSRLNGNRKVRGTLNFDDVDAGLVSDSMVANSLYLQNGSSMSSSTAKSSEKPES 
               
               
                   
               
               
                 325 
                 WD40 repeat 
                 MRPILMKGHERPLTFLKYNREGDLLFSCAKDHTPTVWFADNGERLGTYRGHNGA 
                 165 
                 1145 
               
               
                   
                 protein 
                 VWCCDVSRDSMRLITGSADTTAKLWSVQNGTQLFTFNFDSPARSVDFSIGDKLA 
               
               
                   
                   
                 VITTDPFMELPSAIHVKRIARDPADQASESVLVLRGHQGRIARAVWGPLNKTII 
               
               
                   
                   
                 SAGEDAVIRIWDSETGKLLRESDKETGHKKAVTSLMKSVDGSHFVTGSQDKSAK 
               
               
                   
                   
                 LWDIRTLTLIKTYVTERPVNAVTMSPLLDHVVLGGGQDASAVTMTDHRAGKFEA 
               
               
                   
                   
                 KFFDKILQEEIGGVKGHFGPINALAFNPDGKSFSSGGEDGYVRLHHFDPDYFNI 
               
               
                   
                   
                 KI 
               
               
                   
               
               
                 326 
                 WD40 repeat 
                 MDKKRTVVPLVCHGHSRPVVDLFYSPITPDGFFLISASKDSSPMLRNGETGDWI 
                 529 
                 1569 
               
               
                   
                 protein 
                 GTFEGHKGAVWSCCLDTNALRAASGSADFSAKLWDALSGDELHSFEHKHIVRSC 
               
               
                   
                   
                 AFSEDTHLLLTGGVEKILRIFDLNRPDAPPREVDNSPGSIRTVAWLHSDQTILS 
               
               
                   
                   
                 SCTDIGGVRLWDVRSGKIVQTLETKSPVTSSEVSQDGRYITTADGSTVKFWDAN 
               
               
                   
                   
                 HFGLVKSYNMPCNIESASLEPKLGNKFIAGGEDMWVHIFDFHTGEEIGCNKGHH 
               
               
                   
                   
                 GPVHCVRFSPGGESYASGSEDGTIRIWQTGPANNVEGDANPSNGPVTGKAKVGA 
               
               
                   
                   
                 DEVTRKVEDLQIGKEGKDWREG 
               
               
                   
               
               
                 327 
                 WD40 repeat 
                 MAEGLILKGTMRAHTDMVTAIAIPIDNSDMVVTSSRDKSIILWHLTKEEKVYGV 
                 156 
                 1136 
               
               
                   
                 protein 
                 PRRRLTGHSHFVQDVVLSSDGQFALSGSWDGELRLWDLATGVSARRFVGHTKDV 
               
               
                   
                   
                 LSVAFSIDNRQIVSASRDRTIKLWNTLGECKYTIQEGEAHTDWVSCVRFSPNTL 
               
               
                   
                   
                 QPTIVSASWDRTIKVWNLTNCKLRNTLAGHNGYVNTVAVSPDGSLCASGGKDGV 
               
               
                   
                   
                 ILLWDLAEGKRLYNLEAGAIIHSLCFSPNRYWLCAATENSIKIWDLESKSIVED 
               
               
                   
                   
                 LRVDLKNEADKTDGTTTAASNKKVIYCTSLNWSADGSTLFSGYNDGVIRVWGTG 
               
               
                   
                   
                 RY 
               
               
                   
               
               
                 328 
                 WD40 repeat 
                 MAEGLHLKGTMKAHTDMVTAIAVPIDNADMIVTSSRDKSIILWHLTKEDKVYGV 
                 90 
                 1073 
               
               
                   
                 protein 
                 PRRRLTGHSHFVQDVVLSSDGQFALSGSWDGELRLWDLATGVSARRFVGHTKDV 
               
               
                   
                   
                 LSVAFSIDNRQIVSASRDRTIKLWNTLGECKYTIQEGEAHNDWVSCVRFSPNTL 
               
               
                   
                   
                 QPTIVSASWDRTVKVWNLTNCKLRNTLQGHSGYVNTVAVSPDGSLCASGGKDGV 
               
               
                   
                   
                 ILLWDLAEGKKLYSLEAGAIIHSLCFSPNRYWLCAATENSIKIWDLESKSIVED 
               
               
                   
                   
                 LRVDLKNEADMSDGTTGAMSSNKKVIYCTSLNWSADGSTLFSGYNDGVIRVWGI 
               
               
                   
                   
                 GRY 
               
               
                   
               
               
                 329 
                 WD40 repeat 
                 MAEGLHLKGTMKAHTDMVTAIAVPIDNADMIVTSSRDKSIILWHLTKEDKVYGV 
                 66 
                 1049 
               
               
                   
                 protein 
                 PRRRLTGHSHFVQDVVLSSDGQFALSGSWDGELRLWDLATGVSARRFVGHTKDV 
               
               
                   
                   
                 LSVAFSIDNRQIVSASRDRTIKLWNTLGECKYTIQEGEAHNDWVSCVRFSPNTL 
               
               
                   
                   
                 QPTIVSASWDRTVKVWNLTNCKLRNTLQGHSGYVNTVAVSPDGSLCASGGKDGV 
               
               
                   
                   
                 ILLWDLAEGKKLYSLEAGAIIHSLCFSPNRYWLCAATENSIKIWDLESKSIVED 
               
               
                   
                   
                 LRVDLKNEADMSDGTTGAMSSNKKVIYCTSLNWSADGSTLFSGYNDGVIRVWGI 
               
               
                   
                   
                 GRY 
               
               
                   
               
               
                 330 
                 WD40 repeat 
                 MSGVPAPPFATTTPENGTMSSNSPAFHRDSDDDDDQGEVFLDDSDIIHEVAVDD 
                 227 
                 1512 
               
               
                   
                 protein 
                 EDLPDADDEADEAEEADDSLHIFTGHNGEVYSLACSPTDATLVATGAGDDKGFL 
               
               
                   
                   
                 WRIGHGDWAVELQGHKDSISSLAFSLDGQLLASGSLDGVIQIWDVPSGNLKGTL 
               
               
                   
                   
                 DGPGGGIEWIRWHPKGHIILAGSEDSTVWMWNADKMAYLNMFSGHGNSVTCGDF 
               
               
                   
                   
                 TPDGKTICTGSDDATLRIWNPKSGENIHVVKGHPYHAEGLTSMAISSDSGLAIT 
               
               
                   
                   
                 GAKDGSVRIVNISSGRVVSSLDAHADSVEFVGLALSSPWAATGSLDQKLIIWDL 
               
               
                   
                   
                 QHSSPRATCDHEDGVTCLSWVGASRFLASGCVDGKVRVWDSLSGDCVRTFHGHS 
               
               
                   
                   
                 DAIQSLSVSANEEFLVSVSIDGTARVFEIAEFH 
               
               
                   
               
               
                 331 
                 WD40 repeat 
                 MGTSQHQLSSCLQLLPRRRGNKNLIFRRTMASGGAAAVAPPPGYKPYRHLKTLT 
                 33 
                 1076 
               
               
                   
                 protein 
                 GHVAAVSCVKFSNDGTLLASASLDKTLIIWSSAALSLLHRLVGHSEGVSDLAWS 
               
               
                   
                   
                 SDSHYICSASDDRTLRIWSSRSPFDCLKTLRGHTDFVFCVNFNPQSSLIVSGSF 
               
               
                   
                   
                 DETIRIWEVKTGRCLNVIRAHSMPVTSVHFNRDGSLIVSGSHDGSCKIWDTKNG 
               
               
                   
                   
                 ACLKTLIDDTVPAVSFAKFSPNGKFILVATLNDTLKLWNYATGKFLKIYTGHKN 
               
               
                   
                   
                 SVYCLTSTFSVTNGKYIVSGSEDRCICIWDLQGKNLIQKLEGHSDTVISVTCHP 
               
               
                   
                   
                 SENKIASAGLDSDRTVRIWLQDA 
               
               
                   
               
               
                 332 
                 WD40 repeat 
                 MPSQKIETGHQDIVHDVAMDYYGKRVATASSDTTIKIIGVSNSSGSQHLASLSG 
                 65 
                 973 
               
               
                   
                 protein 
                 HKGPVWQVAWAHPKFGSILASCSYDGQVILWKEGNQNDWAQAHVFNDHKSSVNS 
               
               
                   
                   
                 IAWAPHELGLCLACGSSDGNISVFTARPDGGWDTTRIEQAHPVGVTSVSWAPSM 
               
               
                   
                   
                 APGALVGSGLLDPVQKLASGGCDNTVKVWKLYNGTWKMDCFPALQMHSDWVRDV 
               
               
                   
                   
                 AWAPNLGLPKSTIASASQDGTVVIWTVAKEGEQWQGKVLKDFKTPVWRVSWSLT 
               
               
                   
                   
                 GNLLAVADGNNNVTLWNEAVDGEWQQVTTVEP 
               
               
                   
               
               
                 333 
                 WD40 repeat 
                 MKIAGLKSVENAHDESVWAAAWVPATESRPALLLTGSLDETVKLWRPDELALER 
                 82 
                 1047 
               
               
                   
                 protein 
                 TNAGHFLGVVSVAAHPSGVIAASASIDSFVRVFDVDTNATIATLEAPPSEVWQM 
               
               
                   
                   
                 QFDPKGTTLAVAGGGSASIKLWDTATWELNATLSIPRPEQPKPSEKGNKKFVLS 
               
               
                   
                   
                 VAWSPDGRRLACGSMDGTISIFDVARAKFLHHLEGHFMPVRSLVFSPVEPRLLF 
               
               
                   
                   
                 SASDDAHVHMYDSEGKSLVGSMSGHASWVLSVDVSPDGAALATGSSDRTVRLWD 
               
               
                   
                   
                 LSMRAAVQTMSNHSDQVWGVAFRPMAGAGVRAGGRLASVSDDKSISLYDYS 
               
               
                   
               
               
                 334 
                 WD40 repeat 
                 MEIDLGNLAFDVDFHPSEQLVASGLITGDLLLYRYGDGSSPEKLLEVRAHGESC 
                 43 
                 1101 
               
               
                   
                 protein 
                 RAVRFINDGKAILTGSPDCSILATDVETGSVVARVENAHEAAVNRLVNLTESTI 
               
               
                   
                   
                 ATGDDNGCIKVWDTRQRSCCNTFSAHEDFISDMTFASDSMKLVVTSGDGTLSVC 
               
               
                   
                   
                 NLRSNKVQTRSEFSEDELLSVVIMKNGRKVVCGTQSGTLLLYSWGFFKDCSDRF 
               
               
                   
                   
                 VDLSPSSVDALLKLDEDRIIAGTENGLISLIGILPNRIIQPIAEHSDHPIERLA 
               
               
                   
                   
                 FSHDKKFLGSISHDQTLKLWDLNDILGSEDSPSSQAAIDDSDSDEMDVDANPPD 
               
               
                   
                   
                 SSKGNKKKHSGKGNDVGNANNFFADLGD 
               
               
                   
               
               
                 335 
                 WD40 repeat 
                 MSQQPSVILATASYDHTIRFWEAKSGRCYRTIQYPDSQVNRLEITPHKRYLAVA 
                 142 
                 1095 
               
               
                   
                 protein 
                 GNPSIRLFDVNSNTPQPVMSFDSHTNNVMAVGFQYDGNWMYSGSEDGTVRTWDL 
               
               
                   
                   
                 RARGCQREYESRGAVNTVVLHPNQTELISGDQNGNIRVWDLTANSCSCELVPEV 
               
               
                   
                   
                 DTAVRSLTVMWDGSLVVAANNNGTCYVWRLLRGSQTMTNFEPLHKLQAHNGYIL 
               
               
                   
                   
                 KCLLSPEFCEPHRYLATASSDHTVKIWNVEGFTLEKTLIGHQRWVWDCVFSVDG 
               
               
                   
                   
                 AYLITASSDTTARLWSMSTGQDIRVYQGHHKATTCCALHDGAEGSPG 
               
               
                   
               
               
                 336 
                 WD40 repeat 
                 MEDAMDMEVEVEVEAEEHSPSSSNPSGSSFRRFGLKNSIQTNFGSDYVFEITPK 
                 61 
                 1257 
               
               
                   
                 protein 
                 FDWSLMGVSLSSNAVKLYSPTTGQYCGECRGHSDTVNGISFSGPSSPHVLHSCS 
               
               
                   
                   
                 SDGTIRAWDTRSFKEVSCISAGPSQEIFSFSFGGSSDSLLSAGCKSQILFWDWR 
               
               
                   
                   
                 NKKQVACLEDSHVDDVTQVCFVPHHQNKLISASVDGLICIFDTAGDINDDEHME 
               
               
                   
                   
                 SVINVGTSIGKVGIFGQTFEKLWCLTHIETLSVWDWKEGTNEANFEDARKLASD 
               
               
                   
                   
                 SWSLDHIDYFVDCHSAEEGEGLWVIGGTNAGTLGYFPVKYKGGAAIGSPEAVLG 
               
               
                   
                   
                 GGHSDVVRSVLPMSGMAGTTSKTRGIFGWTGGEDGRLCCWLSDDSSATSRSWMS 
               
               
                   
                   
                 SNLVLKSSRSHHKKNRHQPY 
               
               
                   
               
               
                 337 
                 WD40 repeat 
                 MSQHQEYPMEYAADDYDVGEVEDDMYFHERVMGDSDTDEDEEYDHLDNKITDTS 
                 193 
                 1527 
               
               
                   
                 protein 
                 AADARRGKDIQGIPWERLSVTREKYRRTRIEQYKNYENVPQSGESSEKDCKPTR 
               
               
                   
                   
                 KGGNYYEFWRNTRSVKSTILHFQLRNLVWSTTKHDVYLMSHFSIIHWSSLTCKK 
               
               
                   
                   
                 TEVLDVYGHVAPREKHPGSLLEGFTQTQVSTLAVRDKLLIAGGFQGELICKNLD 
               
               
                   
                   
                 RPGVSYCCRTTYDDNAITNAVEIYDYPSGAVHFMASNNDCGVRDFDMEKFELSR 
               
               
                   
                   
                 HFTFPWPVNHTSLSPDGKLLVIVGDNPEGIVVDSQRGKTIRPLQGHLDFSFASA 
               
               
                   
                   
                 WHPDGHIFATGNQDKTCRIWDIRNLSKSVAVLKGNLGAIRSIRFTSDGRFMAMA 
               
               
                   
                   
                 EPADFVHVYDVKSGYEKEQEIDFFGEISGVSFSPDTESLFVGVWDRTYGSLLQY 
               
               
                   
                   
                 NRCRNYSYLDSM 
               
               
                   
               
               
                 338 
                 WD40 repeat 
                 MGASSDPNPDVSDEHQKRSEIYTYEAPWHIYAMNWSVRRDKKYRLAIASLLDHP 
                 109 
                 1155 
               
               
                   
                 protein 
                 AAAAAVPNRVEIVQLDDSTGEIRADPNLSFDHPYPATKAAFVPDKDCQRADLLA 
               
               
                   
                   
                 TSSDFLRIWRIADDSSRVDLRSFLNGNKNSEFCRPLTSFDWNEAEPKRIGTSSI 
               
               
                   
                   
                 DTTCTIWDIERETVDTQLIAHDKEVYDIAWGGVSVFASVSADGSVRVFDLRDKE 
               
               
                   
                   
                 HSTIIYESSEPDTPLVRLGWNKQDPRYMATIIMDSAKVVVLDIRYPTMPVVELQ 
               
               
                   
                   
                 RHQASVNAIAWAPHSSCHICTAGDDSQALIWDLSSMAQPVEGGLDPILAYTAGA 
               
               
                   
                   
                 EIEQLQWSSSQPDWVAIAFSLKLQ 
               
               
                   
               
               
                 339 
                 WD40 repeat 
                 MRGGGGGGDATGWDEDAYRESVLKEREVQTRTVFRAAFAPSPSPSPSPDAVVVA 
                 71 
                 1213 
               
               
                   
                 protein 
                 SSDGSVASYSISACLSDHRLQSLRFADAKSQNVLEAEPACFLQGHDGPAYDVKF 
               
               
                   
                   
                 YGEGEDSLLLSCGDDGRIRGWMWRDITSSEAHDHSQGNSAKPVLDLVNPQSRGP 
               
               
                   
                   
                 WGALSPIPENNALAVDVKRGSIYAAAGDSCAYCWDVECGKIKTVFKGHSDYLHC 
               
               
                   
                   
                 IAARNSSSQIITGSEDGTARIWDCRSGKCVQVIDPDKDHKKGFFASVSCLALDA 
               
               
                   
                   
                 SESWLVCGRGRDLSVWSISASDCIAKISTNAPAQDVLFDDNQILLVGAEPLISR 
               
               
                   
                   
                 LDMNGAVLSQIHCAPQSVFSVSLHQSGVTAVGGYGGLVDVISQFGSHLCTFRCK 
               
               
                   
                   
                 CI 
               
               
                   
               
               
                 340 
                 WD40 repeat 
                 MEAPIIDPLQGDFPEVIEEYLEHGIMKCIAFNRRGTLLAAGCTDGSCIIWDFET 
                 109 
                 1785 
               
               
                   
                 protein 
                 RGVAKELRDKECTAAITSVCWSKYGHRILVSASDKSLILWDVLSGEKIAHTTLQ 
               
               
                   
                   
                 HTVLQACLHPGSSTPSICLACPFSSAPMIVDLNTGSTTALPVLTADVSNGATPL 
               
               
                   
                   
                 SRNKTSDTSVTYSPCNACFNKHGDLVYAGTSKGEILIIDHKNVRVCAIVLVSGG 
               
               
                   
                   
                 AVIKNVVFSRNGQYMLTNSNDRLIRIYKNLLPPKDGLKMLDELNESFNESDDVE 
               
               
                   
                   
                 KLKAIGSKCLELLHEFQDSITRVQWKAPCFSGDGEWVIGGAASRGEHKIYIWDR 
               
               
                   
                   
                 AGHLVKILEGPKEALMDLAWHPVHPIIISVSLTGLVYIWAKDYTENWSAFAPDF 
               
               
                   
                   
                 KELEENEEYVEREDEFDLVPETEKVKGLDVHEDDEVDVLTVERDSVFSDSDMSQ 
               
               
                   
                   
                 EELCFLPAVPCLDIPEQQDKCVGSCSKLPDGNHSGSPLSVEAGQNGNASNHNSS 
               
               
                   
                   
                 PLEPMENSTADDTDGVRLKRKRKPSEKGLELQAEKVKKPVKPLKSSGRLSKTNK 
               
               
                   
                   
                 PVIDPDSSNGVYGDDGSD 
               
               
                   
               
               
                 341 
                 WD40 repeat 
                 MRGVSWPEDGNNPSTSSSSQRNQQQAHAPRAVSGHAASHPSASNIFKLLVQREV 
                 364 
                 2685 
               
               
                   
                 protein 
                 SPRSKHSSKKLWREASKCQPYPFQQSCEAVRDVRQGLISWVESASLRHLSAKYC 
               
               
                   
                   
                 PLVPPPRSTIAAAFSPDGKILASTHGDHTVKLIDSQTGSCLKVLRGHRRTPWVV 
               
               
                   
                   
                 RFHPLYPEILASGSLDHEVRLWDANTAECIGSRNFYRPIASIAFHARGELLAVA 
               
               
                   
                   
                 SGHKLYIWHYNRRGETSSPTIVLRTQRSLRAVHFHPHAAPFLLTAEVNDLDSAD 
               
               
                   
                   
                 SAMTLATSPGYLHYPPPTVYFADAHSHERSRLADELPLMPLPLLMWPSFTRDDG 
               
               
                   
                   
                 RVPLQRIDGDVGLNGQQRVDSSSSVRLWTYSTPSGQYELLLSPVESGNSPSMPE 
               
               
                   
                   
                 ETGNNAFSSAVEAEVSQSAMDTVEDMEVQPEERNTQFFSFSDPRFWELPLLHGW 
               
               
                   
                   
                 LVGQTQAGPRSVRQSSPGDIETQSAFGEVASVSPITSGVMPVSMDPSRFGGRSG 
               
               
                   
                   
                 SRYRSPGSRGVHVTGPNNDGPRDENDPQSVVSKLRSELAASLAAAASTELPCTV 
               
               
                   
                   
                 KLRIWPHDVKDPCAQLDLESCRLTIPHAVLCSEMGAHFSPCGRFLAACVACVLP 
               
               
                   
                   
                 HLESDPGLHGQVNQDVTGVATSPTRHPISAHQIMYELRIYSLEEATFGIVLASR 
               
               
                   
                   
                 PVRAAHCLTSIQFSPTSEHLLLAYGRRHSSLLKSIVIDGENTVPIYTILEVYRV 
               
               
                   
                   
                 SDMELVRVLPSAEDEVNVACFHPSVGGGLIYGTKEGKLRILHYDSSHGLNLKSS 
               
               
                   
                   
                 GFLDENVPEVQTYALEC 
               
               
                   
               
               
                 342 
                 WD40 repeat 
                 MDSAVAIAALSLVVGAAIALLFFGNYFRKRRSEVVAMAEADLQPHPKNPSRPPP 
                 96 
                 1412 
               
               
                   
                 protein 
                 QPAAKKVHAKSHAHGADKDKNKRHHPLDLNTLKGHGDSVTGLCFASDGRSLATA 
               
               
                   
                   
                 CADGVVRVFKLDDASNKSFKFLRINLPAGGHPTAVAFGDGVSSVIVASQHLSGC 
               
               
                   
                   
                 SLYMYGEEKPTNLDSNKQQTKLPMPEIKWEHHKVHEQKAILTLSGAAANYDSGD 
               
               
                   
                   
                 GSTIIASCSEGTDIIIWHAKTGKILGNVDTNQLKNTMSAISPNGRFIAAAAFTA 
               
               
                   
                   
                 DVKVWEIVYSKDGSVKGVTKVMQLKGHKSAVTWLCFTPNSEQIVTASKDGSIRI 
               
               
                   
                   
                 WNINVRYHLDEDTKTLKVFPIPLQDSSGTTLHYERLSLSPDGKILAATHGSMLQ 
               
               
                   
                   
                 WLCIETGKVLDTAEKAHDGDITCMSWAPQSIPTGDKKVNVLATASGDKKVKLWA 
               
               
                   
                   
                 APPLPS 
               
               
                   
               
               
                 343 
                 WD40 repeat 
                 MEVEPKKASKTFPVKPKLKPKPRTPSGKTPESKYWSSFKTTHPLDNLSFSVPSL 
                 116 
                 1702 
               
               
                   
                 protein 
                 AFSPSPPHLLAAAHSATVSLFSPHRTTISSFSDVVSSLSFRSDGQLLAASDLSG 
               
               
                   
                   
                 LIQVFDVRSRTPLRRLRSHARPVRFVRYPVLDKLHLVSGGDDALVKYWDVAGES 
               
               
                   
                   
                 VVSELRGHKDYVRCGDCSPADANCFVTGSYDHVVKLWDVRVRDGNRAATEVNHG 
               
               
                   
                   
                 SPVQDVIFLPSGSLVATAGGNSVKIWDLIGGGRMVYSMESHNKTVTSICVGTMG 
               
               
                   
                   
                 AQQSGEEGVQLRILSVGLDGYMKVFDYSRMKVTHSMRFPAPLLSIGFSPDSNVR 
               
               
                   
                   
                 AIGTSNGILYVGKRKAKENAEGGANGILGLGSVEEPRRRVLKPSFYRYFHRGQS 
               
               
                   
                   
                 EKPSEGDYLVMRPKKVKLAEHDKLLKKFQHKNALISVLGGNDPEKVVAVMEELV 
               
               
                   
                   
                 ARRALLKCVLNLDADELGLILTFLHKNSTVPRYSSLLLGLAKKVIDLRLEDIRA 
               
               
                   
                   
                 SDALKGHIRNLKRSVDEEIRIQEGLQEIQGMVSPLLRIAGRR 
               
               
                   
               
               
                 344 
                 WD40 repeat 
                 MQGGSSGVGYGLKYQARCISDVKADTDHTSFLTGTLSLKEENEVHLLRLSSGGT 
                 46 
                 1101 
               
               
                   
                 protein 
                 ELICEGLFSHPSEIWDLSSCPFDQRIFSTVFSTGESYGAAVWQIPELYGQLNSP 
               
               
                   
                   
                 QLEKIASLDAHSRKISCVLWWPSGRHDKLVSIDEENIFLWGLDCSKKSAQVQSQ 
               
               
                   
                   
                 ESAGMLHNLSGGAWDPHDVNTVAATCESSIQFWDLRTMKKANSLESVHARDLDY 
               
               
                   
                   
                 DMRKKHLLVTSEDESGVRVWDLRMPKAPIQEFPGHTHWTWAVRCNPDYEGLILS 
               
               
                   
                   
                 AGTDSAVNLWWSSTASSDELISERLIDSPTRKLDPLLHSYNDYEDSVYGLAWSS 
               
               
                   
                   
                 REPWIFASLSYDGRVVVESVKPFLSRK 
               
               
                   
               
               
                 345 
                 WD40 repeat 
                 MAEEEGSAELEQQLEEEFAVWKKNTPILYDLLISHALEWPSLTVHWAPLLPQPS 
                 23 
                 1258 
               
               
                   
                 protein 
                 SSAAAAAGDPSLAAHRLVLGTHTSDGAPNFLILADALLPSSESDHCGDDAVLPK 
               
               
                   
                   
                 VEISQKIRVDGEVNRARFMPQNHNIVGAKTNGCEVYVFDCSKQAAKQHDGGFDP 
               
               
                   
                   
                 DLRLTGHDGEGYGLSWSPLKENYLLSASHDKKICLWDISAAAQDKVLGAMHVFE 
               
               
                   
                   
                 AHEGAVGDASWHSKNDNLFGSAGDDCQLMIWDLRTNKAQQCVKAHEKEVNSVSF 
               
               
                   
                   
                 NSYNDWILATASSDTTVGLFDMRKLTTPLHVFSSHEGEVLQVEWDPNHEAVLAS 
               
               
                   
                   
                 SSEDRRVMVWDLNRIGDEQQEGDASDGPAELLFSHGGHKAKISDFSWNKNEPWV 
               
               
                   
                   
                 ISSVAEDNSVQVWQMAESICGDDDDMQAMEGYI 
               
               
                   
               
               
                 346 
                 WD40 repeat 
                 MGNYGEEDEDQYFDALEETASVSDRGSNSSDCCSSGSGLDENVLDSLGFEFWTK 
                 404 
                 2644 
               
               
                   
                 protein 
                 FPESVRARRNRFLMLTGLGIEANSVDKEDAFPPSCNEIEVYTCKVTRDDGAVQR 
               
               
                   
                   
                 SLDSYNCISLLQSSTSIRSNQEVESLRGDSLLSSFRGRSKESDDLTELCGMGCP 
               
               
                   
                   
                 ESKRNAVSEFGSVSQGSIEELRRIVASSPLVHPLLHRKLEYERELIETKQKMGA 
               
               
                   
                   
                 GWLRKFGSATCISGRQGDTWSDPDDLEITAGMKMRRVRAHSSKKKYKELSSLYA 
               
               
                   
                   
                 AQEFLAHEGSISTMKFSMDGQYLASAGEDTVVRVWKVTEEDRSERVNVTVDPSC 
               
               
                   
                   
                 LYFALNESTQLASLNTNKEHIGKAKTFQRSSDSSCVILPLKVFQITEKPWHEFK 
               
               
                   
                   
                 GHNGEVLDLSWSSKGYLLSSSTDKTVRLWRVGCDRCQRVYSHNDYVTCISFNPV 
               
               
                   
                   
                 NENFFISGSIDGKVRIWNVFGGQVVAYIDCREIVSAVCYRSDGKGAIVGTMTGN 
               
               
                   
                   
                 CLFYSIKDNHLQMDAQVYLHGKKKSPGKRITGFQFPPNDPGKLMITSADSVIRV 
               
               
                   
                   
                 LSGLDVVCKLKGPRNSGGPMIATFTSDGKHVISASEDSNVYIWNYAGQDKTSSR 
               
               
                   
                   
                 VKKIWSCESFWSSNASVALPWCGIRTVPEALAPPSRSEERRASCAENGENHHML 
               
               
                   
                   
                 EEYFQKMPPYSPDCFSLSRGFFLELLPKGSATWPEEKLSDTSPPTVSSQAISKL 
               
               
                   
                   
                 EYKFLKSACHSVLSSAHMWGLVIVTAGWDGRIRTYHNYGLPVRS 
               
               
                   
               
               
                 347 
                 WD40 repeat 
                 MDIDFKEYRLRCELRGHEDDVRGVCVCGDGSIGTSSRDRTVRLWAPSAGERRKY 
                 107 
                 2383 
               
               
                   
                 protein 
                 EVARVLLGHKSFVGPLAWVPPSEELPEGGIVSGGMDTLVMAWDLRNGEAQTLKG 
               
               
                   
                   
                 HQLQVTGIVLDGGDIVSASVDCTLIRWKNGQLTEHWEAHKAPIQAVIRLPSGEL 
               
               
                   
                   
                 VTGSSDTTLKLWRGKTCTQTFVGHTDTVRGLAVMPDLGILSASHDGSIRLWAVS 
               
               
                   
                   
                 GECLMEMVDHTSIVYSVDSHASGLIVSGSEDRFAKIWKDGVCFQSIEHPGCVWD 
               
               
                   
                   
                 VKFLEDGDIVTACSDGTIRIWTNQEDRMANSTELELFDLELSSYKRSRKRVGGL 
               
               
                   
                   
                 KLEELPGLEALQVPGTSDGQTKVIREGDNGVAYAWNSTELKWDKIGEVVDGPED 
               
               
                   
                   
                 SMNRPALDGVQYDYVFDVDIGDGEPTRKLPYNRSDNPYDTADKWLLKENLPLSY 
               
               
                   
                   
                 RQQIVEFILANSGQRDFNLDPSFRDPYTGSSAYVPGAPSQLAAKQARPTFKHIP 
               
               
                   
                   
                 KKGMLVFDAAQFDGILKKINEFNNTLLSNQEKKNLSLTDIEISRLGAVVKILKD 
               
               
                   
                   
                 TSHYHSSKFADADFDLMLKLLESWPYEMMFPVIDIFRMVILHPDGADGLLRHQE 
               
               
                   
                   
                 DKKDVLMESIKRATGNPSVPANFLTSIRAVTNLFKNSAYYSWLQKHRSEMLDAF 
               
               
                   
                   
                 SSCSSSSNKNLQLSYATLLLNYAVLLIEKKDEEGQSQVLSAALELAENESLEVD 
               
               
                   
                   
                 ARYRALVAIGSLMLDGLVKRIALDFDVEHIAKAARTSKEAKIAEVGADIELLIK 
               
               
                   
                   
                 QS 
               
               
                   
               
               
                 348 
                 WD40 repeat 
                 MEFTEAYKQSGPCCFSPNARFIAVAVDYRLVIRDTLSLKVVQLFSCLDKISYIE 
                 243 
                 1625 
               
               
                   
                 protein 
                 WALDSEYILCGLYKRPMIQAWSLIQPEWTCKIDEGPAGIAYARWSPDSRHILTT 
               
               
                   
                   
                 SDFQLRLTVWSLVNTACVHVQWPKHASKGVSFTRDGKFAAICTRHDCKDYINLL 
               
               
                   
                   
                 SCHNWEIMGVFAVDTLDLADIQWSPDDSAIVIWDSPLEYKVLVYSPDGRCLFKY 
               
               
                   
                   
                 QAYESGLGVKSVSWSPCGQFLAVGSYDQMLRVLSHLTWKTFAEFTHLSNVRAPC 
               
               
                   
                   
                 CAAIFKEVDEPLQIDMSELSLSDDYMQGNSGDAPEGHYRVRYDVTEVPITLPCQ 
               
               
                   
                   
                 KPPADRPNPKQGIGLMSWSNDSQYICTRNDSMPTILWIWDMRHLELAAILVQKD 
               
               
                   
                   
                 PIRAAVWDPTGTRLVLCTGSSHLYMWTPSGAYCVSVPLSQFNITDLKWNSDGSC 
               
               
                   
                   
                 LLLKDKESFCCAAAPLPPDESSDYSSDD 
               
               
                   
               
               
                 349 
                 WD40 repeat 
                 MATIAALDDDMVRSMSIGAVFSDFVGKLNSLDFHRKDDILVTAGEDDSVRLYDI 
                 126 
                 1127 
               
               
                   
                 protein 
                 ANARLLKTTFHKKHGTDRVCFTHHPNSLICSSTKNLDTGESLRYISMYDNRSLR 
               
               
                   
                   
                 YFKGHKQRVVSLCMSPINDSFMSGSLDHSVRMWDLRVNACQGILRLRGRPTVAY 
               
               
                   
                   
                 DQQGLVFAVAMEGGAIKLFDSRSYDKGPFDAFLVGGDTSEVCDIKFSNDGKSVL 
               
               
                   
                   
                 LSTTNNNIYVLDAYAGDKQCGFNLEPSPSTPIEASFSPDGQYVVSGSGDGTLHA 
               
               
                   
                   
                 WNISRRNEVACWNSHIGVASCLKWAPRRAMFVAASTVLTFWIPNSEPELASAKG 
               
               
                   
                   
                 EAGVPPEQV 
               
               
                   
               
               
                 350 
                 WD40 repeat 
                 MSVAELKERHRAATETVNSLRERLKQKRVQLLDTDVAGYARTQGKTPVTFGATD 
                 257 
                 1390 
               
               
                   
                 protein 
                 LVCCRTLQGHTGKVYSLDWTPERNRIVSVSQDGRFIVWNALTSQKTHAIRLPCA 
               
               
                   
                   
                 WVMTCAFAPNGQSVACGGLDSVCSIFNLNSPVDRDSNLPVSRMLSGHKGYVSSC 
               
               
                   
                   
                 QYVPDGDAHLITGSGDQTCVLWDITTGLRTSVFGGEFQSGHTADVLSVSTNGSS 
               
               
                   
                   
                 PRIFVSGSCDSTARMWDTRVASRAVHTYHGHESGVNAVKFFPDGNRFGTGSDDG 
               
               
                   
                   
                 TCRLFDIRTGHELQVYYQQRGIDEIPHVTSIAFSISGRLLIAGYSNGDCFVWDT 
               
               
                   
                   
                 LLAQVVLNLGSLQNSHEGRISCLGVSADGSALCTGSWDTNLKIWAFGGIRRVT 
               
               
                   
               
               
                 351 
                 WD40 repeat 
                 MKKRPRGASLDQAVVDIRRREVGGLSGLSFARRLAASEGLVLRLDIYNKLKGHR 
                 178 
                 1632 
               
               
                   
                 protein 
                 GCVNTVGFNLDGDIVISGSDDRHVKLWDWQTGKVKLSFDSGHLSNVFQAKIMPY 
               
               
                   
                   
                 TDDRSIVTCAADGQARHAQILEGGQVQTMLLAKHRGRAHKLAIDPGSPHIVYTC 
               
               
                   
                   
                 GEDGLVQRLDLRSNTARELFTCREVYGTHVEVVHLNAIAIDPRNPNLFVIGGSD 
               
               
                   
                   
                 EYARVYDIRNYKWNGSHNFGRSANYFCPSHLIGEAHVGITGLAFSGQSELLVSY 
               
               
                   
                   
                 NDESIYLFTQEMGLGPDPLSASTKSVDSNSSEVTSPTAVNVDDNVTPQVYKGHR 
               
               
                   
                   
                 NCETVKGVGFFGPKCEYVVSGSDCGRIFIWKKKGGQLIRVMAADKHVVNCIEPH 
               
               
                   
                   
                 PHIPALASSGIENDIKIWTPKAIERATLPMNVEQLKPKARGWMNRISSPRQLLL 
               
               
                   
                   
                 QLYSLERWPEHGGETSSGLAAGQEELTELFFALSANGNGSPDGGGDPSGPLL 
               
               
                   
               
               
                 352 
                 WD40 repeat 
                 MSKRGYKLQEFVAHSSNVNCLSIGKKACRLFLTGGDDCKVNLWAIGKPNSLMSL 
                 290 
                 2917 
               
               
                   
                 protein 
                 CGHTNAVESVAFDSAEVLVLAGASSGVIKLWDVEEAKMVRGLTGHRSNCTAMEF 
               
               
                   
                   
                 HPFGEFFASGSTDTNLKIWDIRKKGCIHTYKGHTRGISTIRFSPDGRWVVSGGN 
               
               
                   
                   
                 DNVVKVWDLTAGKLLHDFKFHENHIRSIDFHPLEFLLATGSADRTVKFWDLETF 
               
               
                   
                   
                 ELIGSSRPEAAGVRAIAFHPDGRTLFCGLEDSLKVYSWEPVICHDGVDMGWSTL 
               
               
                   
                   
                 ADLCIHDGKLLGCSYYQSSVGVWVADASLIEPYGTNVKPQQKDSGDDEIEHQES 
               
               
                   
                   
                 RPSAKVGTTIRSTSIMRCASPDYETKDIKNIYVDTASGNPVSSQRVGTTNFAKV 
               
               
                   
                   
                 TQPLDFNDTPNLTLRRQGLVTETPDGLSGHVPSKSITQPKVVSRDSPDGKDSSR 
               
               
                   
                   
                 RESITFSRTKPGMLLRPAHSRRPSSTKYDVDRLSACAEIGVLSSAKSGSESLVD 
               
               
                   
                   
                 SFLNIKVAPEDGARNGCEDNHSSVKNVSVESEKVLPLQTPKTEKCDQTVGFKEE 
               
               
                   
                   
                 INSVKFVNGVAVVPGRTRTLVEKFEKREKLNSTEDQTINTPENPTLDKTPPPSL 
               
               
                   
                   
                 AENEEKSDRLNIVERKATRMSSHMVTAEDRTPVTLVGSPEDQSTVMAPQRELPA 
               
               
                   
                   
                 DESSKTPPLPVEDLEIHHGSNVSEDKATILSSQTVSEEDSKRSTLIRNFRRRDR 
               
               
                   
                   
                 FKSTEGRSPVMATQRKLPTDESGKTSSLPMEDLEIKGGLNVSEDKATSFSSRAP 
               
               
                   
                   
                 PREDRAHSALVRNVRKRDKFKSTNDTITVMVHQRGLSTDEASTVSVERVERRQL 
               
               
                   
                   
                 SNNVENPLNNLPPHSVPPTTTRGEPQYVGSESDSVNHEDVTELLLGNHEVFLST 
               
               
                   
                   
                 LRSRLTKLQVV 
               
               
                   
               
               
                 353 
                 WD40 repeat 
                 MSTFLTGTALSNPNPNKSYEVVQPPNDSVSSLSFNPKANFLVATSWDNQVRCWE 
                 148 
                 1197 
               
               
                   
                 protein 
                 IVRSGTSLGTTPKASISHDQPVLCSTWKDDGTTVFSGGCDKQVKMWPLSGGQPM 
               
               
                   
                   
                 TVAMHDAPIKEISWIPEMNLLVTGSWDKTLRYWDTRQANPVHIQQLPERCYALT 
               
               
                   
                   
                 VRHPLMVVGTADRNLIIYNLQSPQTEFKRISSPLKYQTRCLAAFPDQQGFLVGS 
               
               
                   
                   
                 IEGRVGVHHLDDSQQSKNFTFKCHREGSEIYSVNSLNFHPVHHTFATAGSDGAF 
               
               
                   
                   
                 NFWDKDSKQRLKAMSRCSQPIPCSTFNNDGSIFAYSACYDWSKGAENHNPATAK 
               
               
                   
                   
                 TYIFLHLPQESEVKGKPRLGTTGRK 
               
               
                   
               
               
                 354 
                 WD40 repeat 
                 MEVEAQQRDVNNVMCQLVDPEGTTLGPPMYLPQDVGPQQLQQMVNKLLSNEDKL 
                 140 
                 1567 
               
               
                   
                 protein 
                 PYTFYISDQELVVPLESYLQKNKVSVEKVLSIVYQPQAIFRIRPVNRCSATIAG 
               
               
                   
                   
                 HSEAVLSVAFSPDGKQLASGSGDTTVRLWDLSTQTPMFTCKGHKNWVLSIAWSP 
               
               
                   
                   
                 DGKHLVSGSKAGEIQCWDPLTGQPSGNPLVGHKKWITGISWEPVHLSSPCRRFV 
               
               
                   
                   
                 SSSKDGDARIWDVTLRRCVICLSGHTLAVTCVKWGGDGVIYTGSQDCTIKVWET 
               
               
                   
                   
                 SQGKLIRELKGHGHWVNSLALSTEYVLRTGAFDHTGKQYSSAEEMKQVALERYK 
               
               
                   
                   
                 KMKGNAPERLVSGSDDFTMFLWEPSVSKHPKTRMTGHQQLVNHVYFSPDGQWVA 
               
               
                   
                   
                 SASFDKSVKLWNGITGKFVAAFRGHVGPVYQISWSADSRLLLSGSKDSTLKIWD 
               
               
                   
                   
                 IRTKKLKRDLPGHADEVFAVDWSPDGEKVVSGGKDKVLKLWMG 
               
               
                   
               
               
                 355 
                 WD40 repeat 
                 MDAGSAHSSSNMKTQSRSPLQEQFLQRRNSRENLDRFIPNRSAMDFDYAHYMLT 
                 376 
                 1737 
               
               
                   
                 protein 
                 EGRKGKENPAVSSPSREAYRKQLAETLNMNRTRILAFKNKPPTPVELIPHELTS 
               
               
                   
                   
                 AQPAKPTKTRRYIPQTSERTLDAPDLLDDYYLNLLDWGSSNVLSIALGNTVYLW 
               
               
                   
                   
                 NASDGSTSELVTIDDETGPVTSVSWAPDGRHIAVGLNNSDVQLWDSADNRLLRT 
               
               
                   
                   
                 LRGGHRSRVGSLAWNNHILTTGGMDGLIVNNDVRVRSHIVDTYRGHTQEVCGLK 
               
               
                   
                   
                 WSASGQQLASGGNDNILHIWDRSTASSNSPTQWLHRLEEHTAAVKALAWCPFQG 
               
               
                   
                   
                 NLLASGGGGGDRTIKFWNTHTGACLNSVDTGSQVCALLWNKNERELLSSHGFTQ 
               
               
                   
                   
                 NQLTLWKYPSMVKIAELTGHTSRVLFMAQSPDGCTVASAAGDETLRFWNVFGVP 
               
               
                   
                   
                 EVAKPAPKANPEPFAHLNRIR 
               
               
                   
               
               
                 356 
                 WD40 repeat 
                 MEEAIPFKNLPSREYQGHKKKVHSVAWNCTGTKLASGSVDQTARVWHIEPHGHG 
                 69 
                 1010 
               
               
                   
                 protein 
                 KVKDIELKGHTDSVDQLCWDPKHADLIATASGDKTVRLWDARSGKCSQQAELSG 
               
               
                   
                   
                 ENINITYKPDGTHVAVGNRDDELTILDVRKFKPIHKRKFNYEVNEIAWNMSGEM 
               
               
                   
                   
                 FFLTTGNGTVEVLAYPSLRPVDTLMAHTAGCYCIAIDPVGRYFAVGSADSLVSL 
               
               
                   
                   
                 WDISEMLCVRTFTKLEWPVRTISFNHTGDYVASASEDLFIDISNVQTGRTVHQI 
               
               
                   
                   
                 PCRAAMNSVEWNPKYNLLAYAGDDKNKYQADEGVFRIFGFESA 
               
               
                   
               
               
                 357 
                 WD40 repeat 
                 MGKDEEEMRGEIEERLINEEYKVWKKNTPFLYDLVITHALEWPSLTVEWLPDRE 
                 149 
                 1423 
               
               
                   
                 protein 
                 EPPGKDYSVQKLVLGTHTSENEPNYLMLAQVQLPLEDAENDARHYDDDRADVGG 
               
               
                   
                   
                 FGCANGKVQIIQQINHDGEVNRARYMPQNSFIIATKTVSAEVYVFDYSKHPSKP 
               
               
                   
                   
                 PLDGACSPDLRLRGHSTEGYGLSWSKFKQGHLLSGSDDAQICLWDINATPKNKS 
               
               
                   
                   
                 LDAMQIFKVHEGVVEDVAWHLRHEYLFGSVGDDQYLLIWDLRTPSVTKPVQSVV 
               
               
                   
                   
                 AHQSEVNCLAFNPFNEWVVATGSTDKTVKLFDLRKISTALHTFDAHKEEVFQVG 
               
               
                   
                   
                 WNPKNETILASCCLGRRLMVWDLSRIDEEQTPEDAEDGPPELLFIHGGHTSKIS 
               
               
                   
                   
                 DFSWNTCEDWVVASVAEDNILQIWQMAENIYHDEDDVPGEESNKGS 
               
               
                   
               
               
                 358 
                 WD40 repeat 
                 MMRGFSCTEDGDAPSTSSTSPPPPPPPPHRQQMQAPRASSSSSGQPTSRRSTGN 
                 365 
                 2677 
               
               
                   
                 protein 
                 VFKLLARREVSPRSKHSLKKFWGEASECQLCPFQQSYEAVRDVRRSLISWVEAF 
               
               
                   
                   
                 SLQHLSAKYCPLMPPPRSTIAAAFSPDGKILASTHGDHTVKLIDSQTGSCLKVL 
               
               
                   
                   
                 RGHRRTPWVVRFHPLYPEILASGSLDHEVHLWDANTAECIGSRNFYRPIASIAF 
               
               
                   
                   
                 HAQGDLLAVASGHKLYIWHYNRSGETSSPTIVLRTPRSLRAVHFHPHAAPFLLT 
               
               
                   
                   
                 AEVNDLDLTDSAMTLATSPGYLHYPPPTIYLADAHSNERSRLEDELPLMPSPLL 
               
               
                   
                   
                 MWPSFTRDDGRATLPHIGGDVGLSGQQRVDSLSSSQYEFHPSPIEPSSSTSMHE 
               
               
                   
                   
                 EMGTDPFSSVRESEVTQSAMNIVDNTEVQPEERSTYSFSFSDPRFWELPSVYGW 
               
               
                   
                   
                 LVGQTQAAPRTAPSPGALETASALGEVASVSPVRSEFMPGGMDQPRLGGRSGSG 
               
               
                   
                   
                 CRSSGSRMMRTAGLNDHPHDENYPQSVVSKLRSELEASLAAAASTELPCTVKLR 
               
               
                   
                   
                 VWPYDMKDPCALFRSESCRLTIPHAVLCSEMGAHFSPCGRFFAACVACVLPQLE 
               
               
                   
                   
                 ADPVLHGQVDPDVTGVATSPTRHPVSAYQIMYELRIYSLEEATFGMVLASRSIR 
               
               
                   
                   
                 AAHCLTSIQFSPTSEHLLLAYGRRHNSLLKSIVIDGENTVPIYSILEVYRVSDM 
               
               
                   
                   
                 ELVRVLPSAEDEVNVACFHPSVGGGLVYGTKEGKLRILQIDSSGGLNPKSTGFL 
               
               
                   
                   
                 DENMAEVPTYALEC 
               
               
                   
               
               
                 359 
                 WD40 repeat 
                 MGEGDLPRTEAGVLRGHEGAVLAARFNGDGNYCLSCGKDRTIRLWNPHRGIHIK 
                 24 
                 923 
               
               
                   
                 protein 
                 TYKSHGREVRDVHCTSDNSKLISCGGDRQIFYWDVSTGRVIRRFRGHDSEVNAV 
               
               
                   
                   
                 KFNDYASVVVSAGYDRSVRAWDCRSHSTEPIQIINTFQDSVMSVCLTKTEIIGG 
               
               
                   
                   
                 SVDGTVRTFDIRIGREISDDLGQPVNCISMSNDGNCILASCLDSTLRLVDRSAG 
               
               
                   
                   
                 ELLQEYKGHTCKSYKLDCCLTNTDAHVAGGSEDGYVFFWDLVDASVISKFRAHS 
               
               
                   
                   
                 SVVTSVSYHPKEDCMITASVDGTIKVWKT 
               
               
                   
               
               
                 360 
                 WD40 repeat 
                 MACIKGVGRSASVAMAPDGGYLATGTMAGTVDLSFSSSASLEIFGLDFQSDDRD 
                 221 
                 3598 
               
               
                   
                 protein 
                 LPLIAESPSSERFNRLSWGKNGSGSDEFSLGLIAGGLVDGTIGLWNPLSLIRSE 
               
               
                   
                   
                 AGDKAIVGHLSRHKGPVRGLEFNVIAPNLLASGADDGEICIWDLAAPREPSHFP 
               
               
                   
                   
                 PLRGSGSAAQGEISFLSWNSKVQHILASTSYNGTTVVWDLKKQKPVISFSDSVR 
               
               
                   
                   
                 RRCSVLQWNPDLATQLVVASDEDSSPTLRLWDMRNIMSPVKEFAGHTRGVIAMS 
               
               
                   
                   
                 WCPNDSSYLVTCAKDNRTICWDTVTGEIVCELPAGSNWNFDVHWYPKIPGVISA 
               
               
                   
                   
                 SSFDGKIGIYNVEGCSRYGVRENEFGAATLRAPKWFKRPVGASFGFGGKVVSFH 
               
               
                   
                   
                 TRSTGGPSVNSSEVFVHDIITEQTLVSRSSEFEAAIQSGDRPSLRALCEKKSQH 
               
               
                   
                   
                 CESTDDQETWGFLKVLLEDDGTARSKLLAHLGFDIPTETNDGSQEDLSQQVNAL 
               
               
                   
                   
                 GLEDVTADKVVQEDNNESMVFPTDNGEDFFNNLPSPRADTPVSTSADGFPTVNA 
               
               
                   
                   
                 AVEPSQDEVDGLEESSDPSFDDSVQRALVVGDYKAAVALCMSANKLADALVIAH 
               
               
                   
                   
                 VGGASLWESTRDKYLKMSRLPYLKVVFAMVNNDLQSLVDTRPLKFWKETLAILC 
               
               
                   
                   
                 SFAQGEEWAMLCNSLASKLMAAGNMLAATLCFICAGNIDKTVEIWSRSLATEHD 
               
               
                   
                   
                 GMSYMDLLQDLMEKTIVLALASGQKQFSASVCKLVEKYAEILASQGLLTTAMDY 
               
               
                   
                   
                 LKLLGTDDLSPELAVLRDRIAFSVEAEKGANISAFNGSQDPRGAVYGVDQSNYG 
               
               
                   
                   
                 MVDTSQHYYPEAAQPQVPHTVPGSPYGENYQQPFGSSFGKGYNTPMQYQAPSQA 
               
               
                   
                   
                 SMFVPSEPPQNAQPSFVPTPVTSQPTTRSQFIPAPPLALRNPEQYQQPTLGSHL 
               
               
                   
                   
                 YPGSVNPTFQPLPHAPGPVAPVPPQVSSVPGQNMPQAVAPTQMRGFMPVTNPGV 
               
               
                   
                   
                 VQNPGPISMQPATPIESAAAQPVVSPAAPPPTVQTADTSNVPAPQKPVIATLTR 
               
               
                   
                   
                 LYNETSEALGGSRANPAKKREIEDNSRKIGALFAKLNSGDISKNAADKLVQLCQ 
               
               
                   
                   
                 ALDNGDYSTALQIQVLLTTSEWDECNFWLATLKRMIKTRQNVRLS 
               
               
                   
               
               
                 361 
                 WD40 repeat 
                 MKERGKGAGRSVDERYTQWKSLVPVLYDWLANHNLVWPSLSCRWGPQLEQATYK 
                 44 
                 1447 
               
               
                   
                 protein 
                 NRQRLYLSEQTDGSVPNTLVIANVEVVKPRVAAAEHISQFNEEARSPFVKKFKT 
               
               
                   
                   
                 IIHPGEVNRIRELPQNSKIVATHTDSPDVLIWDVETQPNRHAVLGASTSRPDLI 
               
               
                   
                   
                 LTGHKDNAEFALAMSPTEPFVLSGGKDRYVVLWSIQDHISTLAADPGSAKSPGS 
               
               
                   
                   
                 AGTNNKQSSKAAGGNDKTGDSPSIEPRGVYLGHGDTVEDVTFCPSSAQEFCSVG 
               
               
                   
                   
                 DDSCLILWDARTGSSPAIKVEKAHHADLHCVDWNPHDVNLILTGSADNTVRMFD 
               
               
                   
                   
                 RRNLTSGGVGSPVHTFEGHNAAVLCVQWSPDKSSVFGSSAEDGILNIWDHEKIG 
               
               
                   
                   
                 RKIETVGSKVPNSPPGLFFRHAGHRDKVVDFHWNSSDPWTIVSVSDDGESTGGG 
               
               
                   
                   
                 GTLQIWRMIDLIYRPEEEVLAELDKFKSHILSCTS 
               
               
                   
               
               
                 362 
                 WD40 repeat 
                 MAKIAPGCEPVAGTLTPSKKREYRVTNRLQEGKRPLYAVVFNFIDSRYFNVFAT 
                 196 
                 1314 
               
               
                   
                 protein 
                 VGGNRVTVYQCLEGGVIAVLQSYIDEDKDESFYTVSWACNIDRTPFVVAGGING 
               
               
                   
                   
                 IIRVIDAGNEKIHRSFVGHGDSINEIRTQPLNPSLIVSASKDESVRLWNVHTGI 
               
               
                   
                   
                 CILIFAGAGGHRNEVLSVDFHPSDKYRIASCGMDNTVKIWSMKEFWTYVEKSFT 
               
               
                   
                   
                 WTDLPSKFPTKYVQFPVFIAPVHSNYVDCNRWLGDFVLSKSVDNEIVLWEPKMK 
               
               
                   
                   
                 EQSPGEGSVDILQKYPVPECDIWFIKFSCDFHYHSIAIGNREGKIYVWELQSSP 
               
               
                   
                   
                 PVLIAKLSHPQSKSPIRQTAMSFDGSTILSCCEDGTIWRWDAITASTS 
               
               
                   
               
               
                 363 
                 WD40 repeat 
                 MNTAMHFGAGWRSIAEMGYTMSRLEIEPESCEDEKSLDGVGNSQGPNELPRCLD 
                 193 
                 1668 
               
               
                   
                 protein 
                 HELAHLTNLKSRPHEHLIRDFPGRRALPVSTVKMLAGRECNYSRRGRFSSADCC 
               
               
                   
                   
                 HMLSRYVPVNGPSPLDQMNSRAYVSQFSADGSLFVAGFQGSHIRIYNVDKGWKC 
               
               
                   
                   
                 QKNILTKSLRWTITDTSLSPDQRYLVYASMSPIVHIVDIGSAAMDSLANITEIH 
               
               
                   
                   
                 EGLDFSADSGPYSFGIFSVKFSTDGREVVAGSSDDSIYVYDLVANKLSLRIPAH 
               
               
                   
                   
                 ESDVNTVCFADESGHIIYSGSDDTYCKVWDRRCLSARNKPAGVLMGHLEGITFI 
               
               
                   
                   
                 DSRGDGRYFISNGKDQTIKLWDIRKMGSDICRRGFRNFEWDYRWMDYPPRARDS 
               
               
                   
                   
                 KHPFDLSVATYKGHSVLRTLIRCYFSPVHSTGQKYIYTGSHDSCVYIYDVVTGA 
               
               
                   
                   
                 QVAALKHHKSPVRDCSWHPEYPMIVSSSWDGDIVKWEFFGNGETEIPAMIKKRIR 
               
               
                   
                   
                 RRHLY 
               
               
                   
               
               
                 364 
                 WD40 repeat 
                 MEPQPQAPKKRGRKPKPKEDKKEEQLHQPPPPPPPQQQAAPAPAPAATRSSTSG 
                 78 
                 1634 
               
               
                   
                 protein 
                 SAGGRDRRPQQQHAVDEKYARWKSLVPVLYDWLANHNLLWPSLSCRWGPQLEQA 
               
               
                   
                   
                 TYKNRQRLYISEQTDGSVPNTLVIANCEVVKPRVAAAEHVSQFNEEARSPFIRK 
               
               
                   
                   
                 YKTIIHPGEVNRVRELPQNPNIVATHTDSPDVLIWDVESQPNRHAVYGATASRP 
               
               
                   
                   
                 NLILTGHQENAEFALAMCPAEPFVLSGGKDKTVVLWSIQDHITASATDQTTNKS 
               
               
                   
                   
                 PGSGGSIIKKTGEGNEETGNGPSVGPRGIYCGHEDTVEDVAFCPSTAQEFCSVG 
               
               
                   
                   
                 DDSCLILWDARVGTNPVAKVEKAHNGDLHCVDWNPHDNNLILTGSADNSVNMFD 
               
               
                   
                   
                 RRNLTSNGVGSPVYKFEGHKAAVLCVQWSPDKPSVFGSSAEDGLLNIWDYERVD 
               
               
                   
                   
                 KKVDRAPNAPAGLFFQHAGHRDKIVDFHWNAADPWTMVSVSDDCDTAGGGGTLQ 
               
               
                   
                   
                 IWRMSDLIYRPEEEVLAELENFKAHVLECSKA 
               
               
                   
               
               
                 365 
                 WD40 repeat 
                 MGIFEPYRAVGYITTGVPFSVQRLGTETFVTVSVGKAFQVYNCAKLSLVLVGPQ 
                 85 
                 2826 
               
               
                   
                 protein 
                 LPKKIRALASYREYTFAAYGSDIGIFKRAHQLATWSGHTAKVCLLLLFGEHILS 
               
               
                   
                   
                 VDVDGNAYIWAFKGMNYNLSPVGHILLDSNFTPSCIMHPDTYLNKVILGSQEGP 
               
               
                   
                   
                 LQLWNISTKTKLYEFKGWNSSVSSCVSSPALDVVAVGCADGKIHVHNIRYDEEL 
               
               
                   
                   
                 VTFSHSMRGSVTALSFSTDGQPLLASGSSSGVVSIWNLDKRRLQSVIRDAHDGS 
               
               
                   
                   
                 IISLHFFANEPVLMSSSADNSIKMWIFDTSDGDPRLLRFRSGHSAPPLCIRFYA 
               
               
                   
                   
                 NGRHILSAGQDRAFRLFSVVQDQQSRELSQRHVSKRAKKLKLKEEEIKLKPVIA 
               
               
                   
                   
                 FDVAEIRERDWCNVVTSHMDTPQAYVWRLQNFVIGEHILRPCPNKPTPVKACMI 
               
               
                   
                   
                 SACGNFAILGTAGGWIERFNLQSGISRGSYIDQLEGTNSAHDGEVVGVACDATN 
               
               
                   
                   
                 TLMISAGYAGDIKVWDFKGRELKSRWEIGSSLVKISYHRLNGLLATVADDFIIR 
               
               
                   
                   
                 LFDAVALRMVRKFEGHTDRITDLCFSEDGKWLLSSSMDGSLRIWDIILARQVDA 
               
               
                   
                   
                 VFVDVSITALSLSPNMDILATTHVDQNGVFLWVNQSMFSGDSDINLYASGKEVV 
               
               
                   
                   
                 TVKLPSVSSVEGSQVEESNEPTIRHSESKDVPSFRPSLEQIPDLVTLSLLPKSQ 
               
               
                   
                   
                 WQSLINLDIIKVRNKPVEPPKKPEKAPFFLPSIPSLSGEILFKPSEMSDKGDMK 
               
               
                   
                   
                 ADEDKSKITPEVPSSRFLQLLHSCSEAKNFSPFTTYIKGLSPSTLDLELRMLQI 
               
               
                   
                   
                 IDDDAVDADADDPQDVDKRQELLSIELLMDYFIHEISCRSNFEFVQALVRLFLK 
               
               
                   
                   
                 IHGETIRRQSVLQNKAKVLLETQCSVWQRVDKLFQGARCMVAFLSNSQF 
               
               
                   
               
               
                 366 
                 WD40 repeat 
                 MEETKVTCGSWIRRPENVNLAVLGRSPRRRGSAALEIFAFDPKSTSLSSSPLVA 
                 74 
                 1246 
               
               
                   
                 protein 
                 HVIEEIEGDPLAIAVHPNGEDIVCFASSGSCLSFELSGQESNLKLLTKELPPLR 
               
               
                   
                   
                 GIGPQKCMAFSVDGSRFATGGVDGRLRILEWPSLRIILDEPKAHKSIRDLDFSL 
               
               
                   
                   
                 DSEFLATTSTDGSARIWKAEDGLPCTTLTRRSDEKIELCRFSKDGTKPFLFCTV 
               
               
                   
                   
                 QRGDKAVTGVWDISTWNKIGHKRLLRKPAVVMSISLDGKYLAQGSKDGDMCVVE 
               
               
                   
                   
                 VKKMEVSHWSKRLHLGTSLTSLEFCPIERVVITTSDEWGVLVTKLNVPADWKAW 
               
               
                   
                   
                 QVYLLLLGLFLASLVAFYIFYENSDSFWGFPLGKDQPARPKIGSVLGDPKSADD 
               
               
                   
                   
                 QNMWGEFGPLDM 
               
               
                   
               
               
                 367 
                 WD40 repeat 
                 MADPVEHQHQQHQQHQLQQQRRRGWRIQGGQYLGEISALCFLHLPPPPLSLSSS 
                 100 
                 4377 
               
               
                   
                 protein 
                 PVLSLSSGLDSESRDRPACSFRFPSAGSGSQVSLFDLASGAMVRTFYVFRGIRV 
               
               
                   
                   
                 HGIVLGCADFPGGSSSSSSTLDYVIAVYGERRVKLFRLSVRLGRGAGEGSGTVL 
               
               
                   
                   
                 SADLELVSAAPRLSHWVMDVRFLKENGTSEDELQRCLTVAIGCSDNSIRLWDVD 
               
               
                   
                   
                 KCSFVLAVSSPERCLLYSMRLWGDNLEDLQVASGTIYNEILIWKVVPNHDAPSS 
               
               
                   
                   
                 NELTEEGLTNSCAGNSVHECLRYEAYHICRLVGHEGSIFRIAWSSDGSKLVSVS 
               
               
                   
                   
                 DDRSARIWEVHCKVQYSEDAGEVGLLFGHSARVWDCYISDNLIVTAGEDCSCRV 
               
               
                   
                   
                 WGLDGQQHDVIKEHIGRGIWRCLYDPWSSLLVTGGFDSAIKVHKLDASLAEASA 
               
               
                   
                   
                 KQSNIKDLSDGTELFTTHLPNSSGHSGHMDSKSEYVRCLSFSCEDVMYIATNHG 
               
               
                   
                   
                 YLYHAKLCNDGDLRWTELAQVSNEVQIICMELLPSNPYDPRIDADDWVAVGDGK 
               
               
                   
                   
                 GWTTVVRVVKNSDSPKVSTSFSWAAEMDRQLLGIHWCKSLGHRFIFTADPRGAL 
               
               
                   
                   
                 KLWRFFEVSQSSSLYPENSPRISLIAEFKSDLGARIMCLDVAFESELLICGDLR 
               
               
                   
                   
                 GNLVLFPLLKDLLLDTFVVSAAKISPVNHFKGAHGISAVSSISVAHMSFNHIEL 
               
               
                   
                   
                 RSTGADGCICYMEYDKGLQSLNFVGMKQVKELSMIESVSTENESTGYRTSGSYA 
               
               
                   
                   
                 SGFASTDFIIWNLVTEAKVLQVSCGGWRRPHSYYLGDVPEMKNCFAYVKDDIIY 
               
               
                   
                   
                 IRRHWIKDSKDKILPQNLRLQFHGREVHSLCFVTGDFQLRKNKQSSWIVTGCED 
               
               
                   
                   
                 GTVRLTRYTQCTDNWSSSKLLGEHVGGSAVRSICCVSNIHTTSSGTSVSDVKGI 
               
               
                   
                   
                 ENLPKDIKGTLMEDECNPSLLISVGAKRVLTSWLLRRRKQDGKEDDVTDLQEAE 
               
               
                   
                   
                 NSSLPSSAGSSTFSFQWLSTDMPVKYSVPSKKSGSIKKLIGVSDTNVRCKSLLP 
               
               
                   
                   
                 DSEALQSKVSAVDKNEDDWRYLAVTAFLVRHSGSRLIVCFIIVACSDATLAIRA 
               
               
                   
                   
                 LVLPYRLWFDVALMVPLSSPVLSLQHVIIGRCQLPDENVQIGNVYVVISGATDG 
               
               
                   
                   
                 SIAFWDLTESVEAFMRRLSNIHLEKFMDCQKRPRTGRGSQGGRWWRSLSKIACK 
               
               
                   
                   
                 EQPINDPVTAKAIKELNRKLTGGVACGSSSSMLDASPELDSNAANSSFEIIEVN 
               
               
                   
                   
                 PFHVLNGVHQSGVNCLHVCETKHGQSSDGRFLYQLVSGGDDQALHLLKFEVLVQ 
               
               
                   
                   
                 PPVQVPDVPNSDIRNSILVEEFLLDEQNQKTKCTIEFISQEKIASAHNSAVKGV 
               
               
                   
                   
                 WTDGTWVFSTGLDQRVRCWISKDRGTPTELAHFIISVPEPEALDARSICWDQYQ 
               
               
                   
                   
                 IAVAGRGMQMIEFHVPSSEIR 
               
               
                   
               
               
                 368 
                 WD40 repeat 
                 MPYKLSATLSNHSSDVRAVASPSDDLILSASRDSTAISWFRQSPSSFTPASVIR 
                 58 
                 2439 
               
               
                   
                 protein 
                 AGSRFVNAIAYLPPTPRAPQGYAVVGGQDTVVNVFALGPGDKEEPEYTLVGHTD 
               
               
                   
                   
                 NVCALSVNSDDTIISGSWDKTAKVWKDFALVYDLKGHQQSVWAVLAMNEKEFLT 
               
               
                   
                   
                 ASADRTIKYWVQHKTMQTYEGHRDAVRGLALIPDIGFASCSNDSEIRVWTMGGD 
               
               
                   
                   
                 VVYTLSGHTSFVYSLSVLPNGDLVSAGEDRSVRVWRDGECSQVIVHPAISVWAV 
               
               
                   
                   
                 STMPNGDIISGSSDGVVRVFSESEKRWATASELKALEDQIASQSLPSQQVGDVK 
               
               
                   
                   
                 KTDLPGPEALSVPGKKAGEVKMIRSGDVVEAHQWDSLASSWQKIGEVVDAIGSG 
               
               
                   
                   
                 RKQLHDGKEYDYVFDVDIQEGAPPLKLPYNVSENPYTAAQRFLEQNDLPTGYLD 
               
               
                   
                   
                 QVVKFIEQNTAGVKLGNDGYVDPFTGASRYQPATQSTSNTASSSYMDPFTGGSR 
               
               
                   
                   
                 HIAESAPSNVPQGSHATGIIPFSKPIFFKLANVSAMQAKMFQFDEVLRNEISTA 
               
               
                   
                   
                 TLAMRPDEVIMVNETFTYLSKVVTSTSSARTSLGWIHIETIMQILDRWPVPQRF 
               
               
                   
                   
                 PVIDLGRLVTAYCMNAFSGPGDLEKFFSCLFRTSEWTSITSGSKALTKAQETNV 
               
               
                   
                   
                 LLLFRTIANSLDGAPLNDMEWIKQIFRELAQTPQLVLNKSHRLALASVLFNFSC 
               
               
                   
                   
                 IGLKGPVPADVRTLHLTIILQVLRSPNDDPEVAYRTCVALGNMLYSDKTRGTPR 
               
               
                   
                   
                 DAQSPSPTELKSAVAAIKGGFSDPRINDVHREIMSLI 
               
               
                   
               
               
                 369 
                 WD40 repeat 
                 MPPQKIESGHKDTVHDLAMDYYGKRLATASSDHTINVVGVSSSGSQHLATLIGH 
                 159 
                 1064 
               
               
                   
                 protein 
                 QGPVWQISWAHPKFGSLLASCSYDGRVIIWREGNPNEWTQAQVFEEHKSSVNSV 
               
               
                   
                   
                 AWAPHELGLCLACGSSDGNISVFTARQDGGWDTSRIDQAHPVGVTSVSWAPSTA 
               
               
                   
                   
                 PGALVGSGMMEPVQKLCSGGCDNTVKVWKLYNRVWKLDCFPVLQMHTDWVRDVA 
               
               
                   
                   
                 WAPNLGLPKSTIASASQDGRVIIWTLAKEGDQWQGKVLYDFRTPVWRVSWSLTG 
               
               
                   
                   
                 NILAVADGNNNVSLWNEAVDGEWIQVSTVEP 
               
               
                   
               
               
                 370 
                 WD40 repeat 
                 MSAPMLEIEARDVVKIVLQFCKENSLHQTFQTLQSECQVSLNTVDSIETFVADI 
                 118 
                 1665 
               
               
                   
                 protein 
                 NSGRWDAILPQVAQLKLPRNTLEDLYEQIVLEMIELRELDTARAILRQTQAMGV 
               
               
                   
                   
                 MKQEQPERYLRLEHLLVRTYFDPNEAYQDSTKEKRRAQIAQALAAEVTVVPPSR 
               
               
                   
                   
                 LMALVGQALKWQQHQGLLPPGTQFDLFRGTAAMKQDVDDMYPTTLSHTIKFGTK 
               
               
                   
                   
                 SHAECARFSPDGQFLVSCSVDGFIEVWDYMSGKLKKDLQYQADETFMMHDDPVL 
               
               
                   
                   
                 CVDFSRDSEMLASGSQDGKIKVWRIRTGQCLRRLERAHSQGVTSVLFSRDGSQL 
               
               
                   
                   
                 LSTSFDGSARIHGLKSGKQLKEFRGHSSYVNDAIFSNDGSRVITASSDCTVKVW 
               
               
                   
                   
                 DVKTSDCLQTFKPPPPLRGGDASVNSVHLFPKNADHIVVCNKTSSIYIMTLQGQ 
               
               
                   
                   
                 VVKSLSSGKREGGDFVAACVSPKGEWIYCVGEDRNLYCFSCQSGKLEHLMKVHE 
               
               
                   
                   
                 KDVIGVTHHPHRNLVATYSEDSTMKLWKP 
               
               
                   
               
               
                 371 
                 WD40 repeat 
                 MDLLQSYAEDNDGDLGRHSSPEPSPPRLLPSKSAAPKVDDTTLALTVAQTNQTL 
                 57 
                 16828 
               
               
                   
                 protein 
                 ARPIDPSQHAVAFNPTYDQLWAPICGPAHPYAKDGIAQGMRNHKLGFVEDAAIG 
               
               
                   
                   
                 SFLFDEQYNTFQRYGYAADPCASTGNEYVGDLDALKQNDGISVYNIRQQEQKKY 
               
               
                   
                   
                 AEEYAKKKGEERGEGGREKAEVVSDKSTFHGKEERDYQGRSWIAPPKDAKATND 
               
               
                   
                   
                 HCYIPKRLVHTWSGHTKGVSAIRFFPKHGHLILSAGMDTKVKIWDVFNSGKCMR 
               
               
                   
                   
                 TYMGHSKAVRDISFCNDGTKFLTAGYDKNIKYWDTETGKVISTFSTGKIPYVVK 
               
               
                   
                   
                 LHPDDEKQNILLAGMSDKKIVQWDMNTGQITQEYDQHLGAVNTITFVDDNRRFV 
               
               
                   
                   
                 TSSDDKSLRVWEFGIPVVIKYISEPHMHSMPSISLHPNTNWLAAQSLDNQILIY 
               
               
                   
                   
                 STRERFQLNKKKRFAGHIVAGYACQVNFSPDGRFVMSGDGEGRCWFWDWKSCKV 
               
               
                   
                   
                 FRTLKCHEGVCIGCEWHPLEQSKVATCGWDGLIKYWD 
               
               
                   
               
               
                 372 
                 WD40 repeat 
                 MESNGNLEQTLQDGRIYRQLNSLIVAHLRDHNFPQAASAVALATMTPLNVEAPR 
                 250 
                 1566 
               
               
                   
                 protein 
                 NRLLELVAKGLAVEKGELLRGVSHAGTNDLGGSIPASYGLVPAPWTAIDFSSLR 
               
               
                   
                   
                 DTKGMSKSFTKHETRHLSDHKNVARCARFSTDGRFFATGSADTSIKLFEVSKIK 
               
               
                   
                   
                 QMMLPDSTDGAIRAVIRTFYDHTHPVNDLDFHPQNTVLISAAKDHTVKFFDYSK 
               
               
                   
                   
                 ATAKRAFRVIQDTHNVRSVAFHPSGDFLLAGTDHPIPHLYDVNTFQCYLSANVP 
               
               
                   
                   
                 EFAVNAAINQVRYSSSGGMYVTASKDGTIRFWDGASANCVRSIAGAHGAAEVTS 
               
               
                   
                   
                 ANFTKDQRYVLSCGKDSTVKLWEVGTGRLVKQYLGATHMQLRCQAVFNNTEEFV 
               
               
                   
                   
                 LSIDEPSNEIVVWDAMTAEKVARWPSNHNGPPRWIEHSPTEAAFVSCGTDRSIR 
               
               
                   
                   
                 FWKETH 
               
               
                   
               
               
                 373 
                 WD40 repeat 
                 MSNFQGEDGEYVADDFEAEDGDEELHGRESADPESDVDEIDTPSNRFTDTTADQ 
                 106 
                 1434 
               
               
                   
                 protein 
                 ARRGRDIQGIPWERLSITREKYRRTRLEQYKNYENVPQSGEKSGKDCTVTEKGN 
               
               
                   
                   
                 SFYEFRRNSRSVKSTILHFQLRNLVWATSKHDVYLMSNYSVVHWSSLTGKKSEV 
               
               
                   
                   
                 LNLAGHVAPNEKHPGSLLEGFTQTQVSTLAVKDRFLVAGGFQGELICKFLDRPG 
               
               
                   
                   
                 ISFCSRTTYDDNAITNAVEIYVSPSGGIHFIASNNDCGVRDFDMENFELSKHFR 
               
               
                   
                   
                 FPWPVNHTSLSPDGKLLVIVGDDPEGILVDAKTGKTIMPLRGHLDFSFASEWHP 
               
               
                   
                   
                 DGVTFATGNQDKTCRIWDIRNLSKSIAVLKGNLGAIRSIRYTSDGRYMAIAEPA 
               
               
                   
                   
                 DFVHVYDTKTGYKKEQEIDFFGEISGMSFSPDTESLFIGVWDRTYGSLLEYGRR 
               
               
                   
                   
                 RNFSYLDCLV 
               
               
                   
               
               
                 374 
                 WD40 repeat 
                 MGVEEDLEDLNALAESTDAAVDGQAALASAVDSVTLQPAPPILPPVIPPPAVPV 
                 190 
                 1917 
               
               
                   
                 protein 
                 VAPVPTIPPVLRPLAPLPIRPPVLRPPAPKRDEAGSSDSDSDHDGTAAGSTAEY 
               
               
                   
                   
                 EITEESRLVRERHEKAMQDLMMKRRGAALAVPTNDKAVRARLRRLGEPMTLFGE 
               
               
                   
                   
                 REMERRDRLRMLMAKLDAEGQLEKLMKAHEDEEAAASAAPEDVEEEMLQYPFYT 
               
               
                   
                   
                 EGSKALFNARIDIAKFSITRAALRLERARRRRDDPDEDVDAEIDWALKKAESLS 
               
               
                   
                   
                 LHCSEIGDDRPLSGCSFSHDGKLLATCSMSGVAKLWDTCRMPQVNRVLTLKGHT 
               
               
                   
                   
                 ERATDVAFSPVQNHIATASADRTAKLWNTEGTILKTFEGHLDRLGRIAFHPSGK 
               
               
                   
                   
                 YLGTTSFDKTWRLWDIESGEELLLQEGHSRSIYGIDFHRDGSLVASCGLDALAR 
               
               
                   
                   
                 VWDLRTGRSILALEGHVKPVLGVSFSPNGYHLATGGEDNTCRIWDLRKKKSLYT 
               
               
                   
                   
                 IPAHANLISEVKFEPQEGYFLVTASYDTTAKVWSARDFKPVKTLSVHEAKITSV 
               
               
                   
                   
                 DITADASHIVTVSHDRTIKLWTSNDDVKEQAMDVD 
               
               
                   
               
               
                 375 
                 WD40 repeat 
                 MVKAYLRYEPAAAFGVIASVESNIAYDASGKHLLAPALEKVGVWHVRQGVCTKA 
                 102 
                 2942 
               
               
                   
                 protein 
                 LAPSASSAAGPSLAVTAIASSPSSLIASGYADGSIRIWDFEKGSCETTLNGHKG 
               
               
                   
                   
                 AVSVLRYGKLGSLLASGSKDNDIILWDVVGETGLYRLRGHRDQVTDLVFLDSDK 
               
               
                   
                   
                 KLVSSSKDKYLRVWDLETQHCMQIVGGHHSEIWSLDTDPEERYLVTGSADPELR 
               
               
                   
                   
                 FYTVKNDSSDERSEADASGGVGNGDLASHNKWDVLKQFGEIQRQSKDRVATVRF 
               
               
                   
                   
                 NKNGNLLACQAAGKLVEVFRVLDEAEAKRKAKRRLHRKREKKGADVNENGDSSR 
               
               
                   
                   
                 GIGEGHDTMVTVADVFKLLQTIRASKKICSISFCPVAPKSSLATLALSLNNNLL 
               
               
                   
                   
                 EFHSIEADKTSKMLTIELQGHRSDVRSVTLSSDNTLLMSTSHNSVKIWNPSTGS 
               
               
                   
                   
                 CLRTIDSGYGLCGLIVPQNKHALIGTKDGAIEIFDVGSGTCIEVVEAHGGSIRS 
               
               
                   
                   
                 IVAIPNQNGFVTGSADHDIKFWEYGMKQKPGDNSKHLTVSNVRTLKMNDDVLVV 
               
               
                   
                   
                 AVSPDAQKIAVALLDCTVKVFFMDSLKLMHSLYGHRLPVLCLDISSDGDLIVTG 
               
               
                   
                   
                 SADKNLMIWGLDFGDRHKSIFAHGDSIMAVQFVGNTHYMFSVGKDRLVKYWDAD 
               
               
                   
                   
                 KFELLLTLEGHHADIWCLAISNRGDFLVTGSHDRSIRRWDRTEEPFFIEEEKEK 
               
               
                   
                   
                 RLEEMFESDLDNAFGNKYVPKEEIPEEGAVALAGKKTQETLSATDSIIEALDIA 
               
               
                   
                   
                 EVELKRIAEHEEEKNNGKTAEFHPNYVMLGLSPSDFILRALSNVQTNDLEQTLL 
               
               
                   
                   
                 ALPFSDALKLLSYLKDWTTYPDKVELVSRIATVLLQTHYNQLVSTPAARPLLTT 
               
               
                   
                   
                 LKDILHKKVKECKDTIGFNLAAMDHLKQLMALRSDALFQDAKVKLLEIRSQLSK 
               
               
                   
                   
                 RLEERTDPREAKRRKKKQKKSTNMHAWP 
               
               
                   
               
               
                 376 
                 WD40 repeat 
                 MGGVQAEREDKDKVSLELTEEILQSMEVGMTFRDYSGRISSMDFHRASSYLVTA 
                 75 
                 1079 
               
               
                   
                 protein 
                 SDDESIRLYDVASATCLKTINSKKYGVDLVSFTSHPMTVIYSSKNGWDESLRLL 
               
               
                   
                   
                 SLHDNKYLRYFKGHHDRVVSLSLCPRNECFISGSLDRTVLLWDQRAEKCQGLLR 
               
               
                   
                   
                 VQGRPATAYDDPGLVFAIAFGGCVRMFDARKYEKGPFEIFSVGGDVSDANVVKF 
               
               
                   
                   
                 SNDGRLMLLTTTDGHIHVLDSFRGTLLYTFNVKPTSSKSTLEASFSPEGMFVIS 
               
               
                   
                   
                 GSGDGSVYAWSVRGGKEVASWLSTDTEPPVIKWAPGNLMFATGSSELSFWIPDL 
               
               
                   
                   
                 SKLGAYVGRK 
               
               
                   
               
               
                 377 
                 WD40 repeat 
                 MAAFGAAPAGNHNPNKSSEVIQPPSDSVSSLCFSPRANHLVATSWDNQVRCWEL 
                 99 
                 1148 
               
               
                   
                 protein 
                 TKNGASVTSVPKASMSHDQPVLCSAWKDDGTTVFSGGCDKQAKMWSLMSGGQPV 
               
               
                   
                   
                 TVAMHDAPIKEIAWIPEMNVLVTGSWDKTLKYWDTRQSNPVHTQQLPERCYAMT 
               
               
                   
                   
                 VRYPLMVVGTADRNLIVFNLQNPQAEFKRFSSPLKYQTRCVAAFPDQQGFLVGS 
               
               
                   
                   
                 IEGRVGVHHLDDSQISKNFTFKCHRDNNDIYSVNSLNFHPVHHTFATAGSDGTF 
               
               
                   
                   
                 NFWDKDSKQRLKAMSRCSQPIPCSTFNNDGTIYAYSVCYDWSKGAENHNPATAK 
               
               
                   
                   
                 TYIFLHLPQESEVKAKPRVGTTNRK 
               
               
                   
               
               
                 378 
                 WD40 repeat 
                 MNCSISGEVPEEPVVSTKSGHVFERRLIERYVSDYGKCPVSGEPLTMDDVLPVK 
                 232 
                 1806 
               
               
                   
                 protein 
                 MGKIVKPRPLQAASIPGLLSIFQNEWDSLMLSNFALEQQLHTARQELSHALYQH 
               
               
                   
                   
                 DAACRVIARLKKERDEARSLLALAERQIPMTASSDIAVNAPAMSNGRKASLDEE 
               
               
                   
                   
                 PGYAGKKMRPGISASIIAEITDCNLALSQQRKKRQIPSTLAPVEDLERYTQLSS 
               
               
                   
                   
                 YPLHKTGKPGITSLDICHSKDIIATGGIDTSAVLFDRSSGQIMSTLSGHSKKVT 
               
               
                   
                   
                 SVNFDAQGDMVLTGSADKTVRIWQGSEDGSYNCRHILKDHTAEVQAITVHATNN 
               
               
                   
                   
                 YFATASLDNTWCFYEFSTGLCLTQVEGASGSEGYTSAAFHPDGLILGTGTSNAD 
               
               
                   
                   
                 VKIWDVKTQANVTTFSGHTGAITAISFSENGYFLATAAQDGVKLWDLRKLKNFR 
               
               
                   
                   
                 TFSAYDKDTGTNSVEFDHSGCYLGLAGSDIRVYQVASVKSEWNCVKTFPDLSGT 
               
               
                   
                   
                 GKVTCVKFGPDSKYIAVGSMDHNLRIFGLPSEDGAMES 
               
               
                   
               
               
                 379 
                 WD40 repeat 
                 MAAPGVETLKKEIKELKEKIAQHRLDTDGEQPLPAAAKSKSVPEVSAALKQRRI 
                 72 
                 1124 
               
               
                   
                 protein 
                 LKGHFGKIYALHWSADSRHLVSASQDGKLIIWNGFTTNKVHAIPLRSSWVMTCA 
               
               
                   
                   
                 YSPSGNLVACGGLDNLCSVYKVPHGGNKESSSAQKTYGELAQHEGYLSCCRFIK 
               
               
                   
                   
                 DNEIVTSSGDSTCILWDVETKTPKAIFNDHTGDVMSLAVFDDKGVFVSGSCDAT 
               
               
                   
                   
                 AKLWDHRVHKQCVMTFQGHESDINSVQFFPDGDAFGTGSDDSSCRLFDIRAYQQ 
               
               
                   
                   
                 INKYSSDKILCGITSVAFSKTGKSLFAGYDDYNTYVWDTLSGNQVEVLTGHENR 
               
               
                   
                   
                 VSCLGVSEDGKALATGSWDTLLKIWA 
               
               
                   
               
               
                 380 
                 WD40 repeat 
                 MGGVEDESEPASKRMKLSSRVLRGLANGSSRTEPAAGSSLDLMARPLPIEGDEE 
                 315 
                 2069 
               
               
                   
                 protein 
                 VIGSKGVIKRVEFVRLIAKALYSLGYEKSGARLEEESGIPLQSSVVNLFMQQIS 
               
               
                   
                   
                 DGLWDESVVTLHKIGLSDENLVKSASFLILEQKFLELLDQEKAMDALKTLRTEI 
               
               
                   
                   
                 TPLCIKNSRVRELSSCIISPSSCGLLNQNKRNSTRARSRSELLEELQKLLPPAV 
               
               
                   
                   
                 IIPERRLEHLVEQALVLQTDACMLHNSIDMEMSLYTDHQCGKEHIPCRTLQILQ 
               
               
                   
                   
                 SHNDEVWLVQFSHNGKYLASASNDRSAIIWEVDENGSVSLKHKLTGHQKPISSV 
               
               
                   
                   
                 CWSPDDRQLLTCGVGETVRRWDVSSGECLRVYEKAGHGLISCAWFPDGKWICYG 
               
               
                   
                   
                 VSDRSICMCDLEGKEIECWKGQRTLSISDLEITSDGKQIISICRETAILLLDRE 
               
               
                   
                   
                 AKYERMIEENQTITSFSLSKDNRYLLVNLLNQEIHLWDIKGDFRLVAKYKGLKR 
               
               
                   
                   
                 SRFVIRSCFGGLKQAFVASGSEDSQVYIWHKGSGELIEPLPGHSGAVNCVSWNP 
               
               
                   
                   
                 ANHHMLASASDDRTIRIWGLNELNTRHKGARPNGVHYCNGNGTS 
               
               
                   
               
               
                 381 
                 WD40 repeat 
                 MTQLAETYACMPSTERGRGILIAGNPKPGSNSVLYTNGRSVVILNLDNPLDISV 
                 145 
                 1968 
               
               
                   
                 protein 
                 YAEHAYPATVARFSPNGEWVASADSSGAVRIWGAYNDHVLKKEFKVLSGRIDDL 
               
               
                   
                   
                 QWSPDGLRIVASGDGKGKSLVRAFMWDSGTNVGEFDGHSRRVLSCAFKPTRPFR 
               
               
                   
                   
                 IVTCGEDFLVNFYEGPPFKFKLSRRDHSNFVNCLRFSPDGNRFISVSSDKKGII 
               
               
                   
                   
                 YDGKTGEKIGELSSDGGHTGSIYAVSWSPDSKQVITVSADKSAKIWDISEDGSG 
               
               
                   
                   
                 NLRKTLTSSGSGGVDDMLVGCLWQNNHLVTVSLGGTISIYTAGDLDKAPVSFSG 
               
               
                   
                   
                 HMKNVSSLSVLKGDPKVILSSSYDGLIIKWIQGIGFSGRVQRKESTQIKCLAAV 
               
               
                   
                   
                 DEEIVTSGYDNKVCRVSGSGDAEFIDIGCQPKDLSLALQCPEFALVSTDTGVVL 
               
               
                   
                   
                 LRGAKIVSTINLGFAVTASTVAPDGTEAIIGAQDGKLRIYSISGDTLTEEAVLE 
               
               
                   
                   
                 KHRGAISVIHYSPDLSMFASGDLNREAVVWDRASREVRLKNILYHTARINCLAW 
               
               
                   
                   
                 SPDSSTVATGSLDTCVIIYEVDKPASNRLTIKGAHLGGVYGLAFTDDFSVVSSG 
               
               
                   
                   
                 EDACIRVWKINRQ 
               
               
                   
               
               
                 382 
                 WD40 repeat 
                 MKVKVISRSTDEFTRERSQDLQRVFRNFDPNLRTQEKAVEYVRALNAAKLDKVF 
                 130 
                 1488 
               
               
                   
                 protein 
                 ARPFVGAMDGHVDSVSCMAKNPNYLKGIFSGSMDGDIRLWDIASRRTVCQFPGH 
               
               
                   
                   
                 QGPVRGLAASTDGQILVSCGIDSTVRLWNVPVATLGESDGTHENLAKPLAVYVW 
               
               
                   
                   
                 KNAFWAVDHQWDGELFATAGAQVDIWNQNRSQPISSFEWGTDTVISVRFNPGEP 
               
               
                   
                   
                 NVLATSGSDRSITLYDLRMSSPTRKVIMRTKTNAISWNPMEPMNFTAANEDCNC 
               
               
                   
                   
                 YSYDARKLEEAKCVHKDHVSAVMDIDYSPTGREFVTGSYDRTVRIFQYNGGHSR 
               
               
                   
                   
                 EVYHTKRMQRVFCVKFSCDASYVISGSDDTNLRLWKAKASEQLGVVLPRERRKH 
               
               
                   
                   
                 EYHEAVKSRYKHLPEVKRIVRHRHLPKPIYKAGILRRTVNEADRRKEERRKAHS 
               
               
                   
                   
                 APGSSSAEPLRKRRIIKEIE 
               
               
                   
               
               
                 383 
                 WD40 repeat 
                 MVRSIKNPKKAKRKNKGSKNGDGSSSSSSIPSMPTKVWQPGVDKLEEGEELQCD 
                 269 
                 1693 
               
               
                   
                 protein 
                 PSAYNSLHAFHIGWPCLSFDIVRDTLGLVRTEFPHQVYFVAGTQAEKPTWNSIG 
               
               
                   
                   
                 IFKVSNITGKRRELVPSKPTDDADEESDSSDSDEDSDDEVGGSGTPILQLRKVG 
               
               
                   
                   
                 HEGCVNRIRAMNQNPHICASWGDSGHVQIWDFSSHLNALAESEADVSQGASSVF 
               
               
                   
                   
                 NQAPLVKFGGHKDEGYALDWSPLVPGRLVSGDCKNSIHLWEPTSGSTWNVDSTP 
               
               
                   
                   
                 FIGHAASVEDLQWSPTEENVFASCSVDGTIAIWDTRLGKTPAASFKAHDADVNV 
               
               
                   
                   
                 ISWNRLATCMLASGCDDGTFSIHDLRLLKEGDSVVAHFEYHKHPVTSIEWSPHE 
               
               
                   
                   
                 ASTLAVSSADCQLTIWDLSLEKDEEEEAEFKAKTKEQVNAPEDLPPQLLFVHQG 
               
               
                   
                   
                 QKDLKELHWHAQIPGMIVSTAADGFNILMPSNIQSTLPSDGA 
               
               
                   
               
               
                 384 
                 CDK type A 
                 MERYKVIKELGDGTYGSVWKALNQQTHEIVAIKKMKRKYYIWEECINLREVKSL 
                 1163 
                 2545 
               
               
                   
                   
                 RKLNHPNIIKLKEVIRENNELFFIFEYMECNLYQIMKERSTPFSETAIIKFCYQ 
               
               
                   
                   
                 ILQGLSYMHRNGYFHRDLKPENLLVTSDLIKIADFGLAREVLTSPPYTDYVSTR 
               
               
                   
                   
                 WYRAPEVLLQSPTYTTAIDMWAVGAILAELFTLHPLFPGESELDEIYKICGVLG 
               
               
                   
                   
                 TPDYETWPDGMQLAAFRNFIFPQFLPVNLSVLIPHASPEAIDLITRLCSWDPQK 
               
               
                   
                   
                 RPTAEQALHHPFFRIGMSIPLSLGGHFQDNTCAAEVDTNFHSKKACKGRGMGEK 
               
               
                   
                   
                 ESSLECFLGLSLGLKPSLGHLGAMGSQGVGAVKQEVGSSPGCQSNPKQSLFQVL 
               
               
                   
                   
                 NSRAILPLFSSSPNLNVVPVKSSLPSAYTVNSQVMWPTIAGPPAAAVTVSTLQP 
               
               
                   
                   
                 SILGDFKIFGKSMGLASQYAGKEASPFS 
               
               
                   
               
               
                 385 
                 CDK type A 
                 MGEMGRGINNSSNNNNSNRPAWLQHYDLVGKIGEGTYGLVFLARSKLPNNRGLR 
                 152 
                 1582 
               
               
                   
                   
                 IAIKKFKQSKDGDGVSPTAIREIMLLREFSHENVVKLVNVHINHVDMSLYLAFD 
               
               
                   
                   
                 YAEHDLYEIIRHHREKLNHHNINQYTVKSLLWQLLNGLNYLHSNWIVHRDLKPS 
               
               
                   
                   
                 NILVMGEGEEHGVVKIADFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKH 
               
               
                   
                   
                 YTSAVDMWAVGCIFAELITLKPLFQGVEVKASPNPFQLDQLDKIFKVLGHPTIE 
               
               
                   
                   
                 KWPTLMNLPHWSKNLQQIQQHKYDNAGLHIGPIPAKSPAYDLLSKMLEYDPRKR 
               
               
                   
                   
                 ITAAQALEHEYFRIDPQPGRNALVPSQPGEKAINYPPRLVDANTDFDGTIAPQP 
               
               
                   
                   
                 SQVSSGNAPSGSIASAAVPAVRPLPQQMQLMGMQRMQNPGMAAFNLGAQASMSG 
               
               
                   
                   
                 LNHNNIALQRGSSQQQAHQQVRRKEPNSGFPNTGYPPPPKSRRL 
               
               
                   
               
               
                 386 
                 CDK type B-1 
                 MDKYEKLEKVGEGTYGKVYKARDKMTGQLVALKKTRLEMDEEGVPPSSLREISL 
                 389 
                 1297 
               
               
                   
                   
                 LQMLSQSIYVVRLLCVEHVTKKGKPLLYLVFEYLDTDLKKFIDYRRSVNAGPLP 
               
               
                   
                   
                 QNVIQSFMYQLLKGVAHCHSHGVLHRDLKPQNLLVDKSKGLLKVGDLGLGRAFT 
               
               
                   
                   
                 VPLKCYTHEVVTLWYRAPEVLLGSTHYSTPVDIWSVGCIFAEMVRRQPLFPGDC 
               
               
                   
                   
                 EIQQLLHIFTLLGTPTEEMWPGVKRLRDWHEYPQWKPENLARAVPNLSPTGLDL 
               
               
                   
                   
                 ISKMLQCDPAKRISAKAAMNHPYFDDLDKSQF; 
               
               
                   
               
               
                 387 
                 CDK type B-1 
                 MDGYEKMDKVGEGTYGKVYMARDKKTGQLVALKKTRLENDGEGIPPTALREISL 
                 38 
                 946 
               
               
                   
                   
                 LQMLSQDIYIVRLLDVKHTENKLGKPLLYLVFEYMESDLKKYIDSYRRSHTKMP 
               
               
                   
                   
                 PSMIKSFMYQLCRGVAYCHSRGVMHRDLKPHNLLVDKEKGVLKIADLGLSRAFT 
               
               
                   
                   
                 VPVKKYTHEIVTLWYRAPEVLLGATHYSLPVDIWSVGCIFAEMSRMQALFTGDS 
               
               
                   
                   
                 EVQQLMNIFRFLGTPNEEVWPGVTKLKDWHIYPEWKPQDISHAVPDLEPSGLDL 
               
               
                   
                   
                 LSQMLVYEPSKRISAKKALEHPYFDDLDKSQF 
               
               
                   
               
               
                 388 
                 CDK type B-1 
                 MDAYEKLEKVGEGTYGKVYKAKDKNTGQLVALKKTRLESDDEGIPPTALREISL 
                 180 
                 1088 
               
               
                   
                   
                 LQMLSQDIHIVRLLDVEHTENKNGKPLLYLVFEYMDSDLKKYIDGYRRSHTKVP 
               
               
                   
                   
                 PNIIKSFMYQLCQGVAYCHSRGVMHRDLKPHNLLVDKQRGVVKIADLGLGRAFT 
               
               
                   
                   
                 IPIKKYTHEIVTLWYRAPEVLLGATHYSTPVDIWSVGCIFAEMVRLQALFIGDS 
               
               
                   
                   
                 EVQQLFKIFSFLGTPNEEIWPGVTKFRDWHIYPQWKPQDISSAVPDLEPSGVDL 
               
               
                   
                   
                 LSKMLVYEPSKRISAKKALEHPYFDDLDKSQF 
               
               
                   
               
               
                 389 
                 CDK type B-1 
                 MDSYEKLEKVGEGTYGKVYKAKDKKTGKLVALKKTRLENDGEGIPPTALREISL 
                 40 
                 948 
               
               
                   
                   
                 LQMLSQDMNIVRLLDVEHTENKNGKPLLYLVFEYMDSDLKKYVDGYRRSHTKMP 
               
               
                   
                   
                 PKIIKSFMYQLCQGVAYCHSRGVMHRDLKPHNLLVDKQRGVLKIADLGLGRAFT 
               
               
                   
                   
                 VPIKKYTHEIVTLWYRAPEVLLGATHYSTPVDIWSVGCIFAEMSRMHALFCGDS 
               
               
                   
                   
                 EVQQLMSIFKFLGTPNEGVWPGVTKLKDWHIYPEWRPQDLSRAVPDLEPSGVDL 
               
               
                   
                   
                 LTKMLVYEPSKRISAKKALQHPYFDDLDKSQF 
               
               
                   
               
               
                 390 
                 CDK type B-1 
                 MEKYEKLEKVGEGTYGKVYKGRDKRTGRLVALKKTPFHQEEGIPPTAIREISLL 
                 299 
                 1134 
               
               
                   
                   
                 KSLSQCIYIVKLLDVKASFNGKGKHVLFMVFEYADSDLKKHIDAHRQCNTKLSP 
               
               
                   
                   
                 RSIQSYMFQLCKGIAYCHSHGVLHRDLKPQNILVDQKIGLLKIADLGLGRACTV 
               
               
                   
                   
                 PIKSYTFEVVTLWYRAPEVLLGAKRYSMALDIWSLGCIFAELCNLQALFAGDSQ 
               
               
                   
                   
                 IQQLINIFRLLGTPNEQLWPGVTQLSDWHEFPQWRPQDLSKVVFNLDPNGVDLL 
               
               
                   
                   
                 SKMLQYDPAKRISAKEALDHPYFDSLDKSQF 
               
               
                   
               
               
                 391 
                 CDK type C 
                 MGCVCGKPSARAADYVESPAEKGASSNSRSSSMASRRLVAPAVMDQGIDAENGH 
                 105 
                 2642 
               
               
                   
                   
                 EGDYRTKLRGKQSNGADPVSLLSDDAEKQRHSRHHQHQQHHPIRPHHLRPQGEF 
               
               
                   
                   
                 VPNANSNPRFGNPPRHIEGEQVAAGWPAWLTAVAGEAIKGWIPRRADSFEKLDK 
               
               
                   
                   
                 IGQGTYSNVYKARDLDTGKIVALKKVRFDNLEPESVRFMAREIQVLRRLDHPNV 
               
               
                   
                   
                 VKLEGLVTSRMSCSLYLVFEYMDHDLAGLAACPGIKFTEPQVKCYMQQLLRGLD 
               
               
                   
                   
                 HCHSRGVLHRDIKGSNLLIDNGGILKIADFGLATFFHPDQRQPLTSRVVTLWYR 
               
               
                   
                   
                 PPELLLGATEYGVAVDLWSTGCILAELLAGKPIMPGRTEVEQLHKIFKLCGSPS 
               
               
                   
                   
                 EDYWKKSKLPHATIFKPQQPYKRCVAETFKDFPPSALALMEVLLAIEPADRGTA 
               
               
                   
                   
                 TSALKSDFFTTKPLACDPSSLPKYPPSKEFDAKIRDEEARRQRAAGGRGRDAAR 
               
               
                   
                   
                 RPSRESRAIPAPEANAELAISIQKRRLSSQGPSKSKSEKFNPQQEDGAVGFPIE 
               
               
                   
                   
                 PPRPMHIGIDAGATSRMYSQQFGPSHSGPLSNQISSSIWGKNQKEDEIQMAPGR 
               
               
                   
                   
                 PSRSSKATISDFRKPGACAPQPGADLSHLSSLVATARSNAGIDTHKDRSGMWQH 
               
               
                   
                   
                 NRIDAIDGVHNNGKHEFLEVPEHPNRQDWTRFQQPESFKGLDNYHLQDLPATHH 
               
               
                   
                   
                 RKDERVASKEATMNWQGYGGQGGDKIHYSGPLLPPSGNIDEILKEHERHIQHAV 
               
               
                   
                   
                 RRARQDKGRPQRSNLSQNERKAFEHRSFVSGVNGNAGYSDLVNELPISVGSNRL 
               
               
                   
                   
                 KVSKTRGTEEIVELRELEREPLSSVMEKYEREHEM 
               
               
                   
               
               
                 392 
                 CDK type C 
                 MGCVCAKQSDILGEPESPKVKGSNLASSRWSVSSETKQLPQHSDSGILHHQHYY 
                 187 
                 2580 
               
               
                   
                   
                 HPRDESDEAKLKESNYGGSKRRTRQGRDPADLDMGIFVRTPSSQSEAELVAAGW 
               
               
                   
                   
                 PAWMAAFAGEAIHGWIPRRAESFEKLYKIGQGTYSNVYKARDLDNGKIVALKKV 
               
               
                   
                   
                 RFDSLDAESVRFMAREILVLRKLDHPNIVKLEGLVTSEVSSSLYLVFEYMEHDL 
               
               
                   
                   
                 AGLAACPGIKFTEPQVKCYMQQLLQGLDHCHRHGVLHRDIKGSNLLIDNGGILK 
               
               
                   
                   
                 IADFGLATFFYPDQKQLLTSRVVTLWYRPPELLLGATDYGVAVDIWSAGCILAE 
               
               
                   
                   
                 LLAGKPILPGRTEVEQLHKTFKLCGSPSEDYWKESKLPHATIFKPQHPYKSCIA 
               
               
                   
                   
                 EAFKDFSPSALALLETLLAIEPGHRGEASGALKSEFFTTEPLSCDPSSLPKYPP 
               
               
                   
                   
                 SKEFDAKLRAQETRRQRDVGVRGHGSEAARRTSRLSRAGPTPNEGAELTALTQK 
               
               
                   
                   
                 QHSTSHATSNIGSEKPSTKKEDYTAGLHIDPPRPVNHSYETTGVSRAYDAIRGV 
               
               
                   
                   
                 AYSGPLSQTHVSGSTSGKKPKRDHVKGLSGQSSLQPSKPFIVSDSRSERIYEKS 
               
               
                   
                   
                 HVTDLSNHSRLAVGRNRDTTDPHKSLSTLMQQIQDGTLDGIDIGTHEYARAPVS 
               
               
                   
                   
                 STKQKSAQLQRPSALKYVDNVQLQNTRVGSRQSDERPANKESDMVSHRQGQRIH 
               
               
                   
                   
                 CSGPLLHPSANIEDLLQKHEQQIQQAVRRAHHGKREALSNKSSLPGKKPVDHRA 
               
               
                   
                   
                 WVSSGKGNKESPYFKGKGNKELSDLKGGPTAKVTNFRQKVM 
               
               
                   
               
               
                 393 
                 CDK type C 
                 MAVANPGQLNLQEAPSWGSRSVNCFEKLEQIGEGTYGQVYMAKEIETGEIVALK 
                 220 
                 1749 
               
               
                   
                   
                 KIRMDNEREGFPITAIREIKLLKKLQHENVIKLKEIVTSPGPEKDEQGKSDGNK 
               
               
                   
                   
                 YNGSIYMVFEYMDHDLTGLAERPGMRFSVPQIKCYMKQLLIGLHYCHINQVLHR 
               
               
                   
                   
                 DIKGSNLLIDNNGILKLADFGLARSFCSDQNGNLTNRVITLWYRPPELLLGSTK 
               
               
                   
                   
                 YGPAVDMWSVGCIFAELLYGKPILPGKNEPEQLTKIFELCGSPDESNWPGVSKL 
               
               
                   
                   
                 PWYSNFKPQRQMKRRVRESFKNFDRHALDLVEKMLTLDPSQRISAKDALDAEYF 
               
               
                   
                   
                 WTDPVPCAPSSLPRYEPSHDFQTKRKRQQQRQHDEMTKRQKISQHPPQQHVRLP 
               
               
                   
                   
                 PIQNAGQGHLPLRPGPNPTMHNPPPQFPVGPSHYTGGPRGAGGQNRHPQNIRPL 
               
               
                   
                   
                 HAAQGGGYNANRGYGGPPQQQGGGYPPHGMGNQGPRGGQFGGRGAGYSQGGPYG 
               
               
                   
                   
                 GPVGGRGPNVGGGNRGPQFWSEQ 
               
               
                   
               
               
                 394 
                 CDK type D 
                 MQNMEDNVQSSWSLHGNKEICARYEILERVGSGTYSDVYRGRRKADGLIVALKE 
                 438 
                 1748 
               
               
                   
                   
                 VHDYQSSWREIEALQRLCGCPNVVRLYEWFWRENEDAVLVLEFLPSDLYSVIKS 
               
               
                   
                   
                 GKNKGENGIPEAEVKAWMIQILQGLADCHANWVIHRDLKPSNLLISADGILKLA 
               
               
                   
                   
                 DFGQARILEEPEAIYEVEYELPQEDIVADAPGERLMEEDDSVKGVRNEGEEDSS 
               
               
                   
                   
                 TAVETNFGDMAETANLDLSWKNEGDMVMQGFTSGVGTRWYRAPELLYGATIYGK 
               
               
                   
                   
                 EIDLWSLGCILGELLILEPLFSGTSDIDQLSRLVKVLGTPTEENWPGCSNLPDY 
               
               
                   
                   
                 RKLCFPGDGSPVGLKNHVPSCSDSVFSILERLVCYDPAARLNAKEVLENKYFVE 
               
               
                   
                   
                 DPYPVLTHELRVPSPLREENNFSEDWAKWKDMEADSDLENIDEFNVVHSSDGFC 
               
               
                   
                   
                 IKFS 
               
               
                   
               
               
                 395 
                 CDK type D 
                 MDLNQYPEDLNPELPEGTDNVDNPDNNKGSPVPSPHPPLKPLDPSERYRKGITL 
                 240 
                 1631 
               
               
                   
                   
                 GQGTYGIVYKAFDTVTNKTVAVKKIHLGKAKEGVNVTALREIKLLKELSHPNII 
               
               
                   
                   
                 QLIDAYPHKQNLHIVFEFMETDLEAVIKDRNLVFSPADIKSYLQMTLKGLAVCH 
               
               
                   
                   
                 KKWVLHRDMKPNNLLIAADGQLKLGDFGLARLFGSPDRKFTHQVFAVWYRAPEL 
               
               
                   
                   
                 LFGAKQYGPAVDIWATGCIFAELLLRKPFLQGVSDLDQIGKIFAAFGTPRQSQW 
               
               
                   
                   
                 PDVASLPDFVEFQFVPAPSLRSLFPMASEDALDLLSKMFTLDPKNRITAQQALE 
               
               
                   
                   
                 HRYFSSVPAPTRPDLLPKPSKVDSSRPPKHASPDGPVVLSPSKARRVMLFPNNL 
               
               
                   
                   
                 AGILPKQVSQSTTGGTPIEFDMPTQKLREVCPRSRITESGKKHLKRKTMDMSAA 
               
               
                   
                   
                 LDECAREQEGQEGKTILDPDHQRSAKKEKHM 
               
               
                   
               
               
                 396 
                 Cyclin A 
                 MAGGQENCVRITRARAACVSKASAPVIQSQVDEKKSRKRAPKRAAVDDLAANAS 
                 252 
                 1604 
               
               
                   
                   
                 GSQPKRRAVLGDVTNLHAAATDCLSTAEDQVDAPNPSIKGRARNKKKEARTSTK 
               
               
                   
                   
                 VVKDEIHPESNPLADHSSNLSECQKPPAAKLAEQRSLRGVPSKAKQGGSSNSQS 
               
               
                   
                   
                 CSKHTDIDKDHTDPQMCTTYVEDIYEYLRNAELKNRPSANFMETAQNDITPNMR 
               
               
                   
                   
                 AILVDWLVEVSEEYKLVPDTLYLTVSYIDRYLSANPTSRHKLQLLGVSCMLIAS 
               
               
                   
                   
                 KYEEVCPPHVEEFCYITDNTYTRDEMLSMERKILIFLNFEMTKPTTKSFLRRFV 
               
               
                   
                   
                 RASQAGNKAPSLHMEFLANYLAELTLMECSFLQYLPSLIAASTVFLSRLTLDFL 
               
               
                   
                   
                 TNPWNPTLAHYTGYKASQLKDCVMAIYNVQMNRKGSTLVAIREKYQQHKFKCVA 
               
               
                   
                   
                 SLPPPPFIAERFFEDTPN 
               
               
                   
               
               
                 397 
                 Cyclin A 
                 MTGTQASNVRITRARAAKSTLNNALPPLPPAQGKPRGKRAATESNISGFSVAAE 
                 261 
                 1817 
               
               
                   
                   
                 PLKRRAVLSDVSNICKEAAAVDCLKKPKAVKVVSQNANAKGRGRGIPRNNKKIT 
               
               
                   
                   
                 QEAEIKKETSPAICNVDDASAGNAIGDDKQNNNVNPLKEVQDNPKELNPIAEQI 
               
               
                   
                   
                 SVHPHCKQSVEKPNEKEIVVSDNKAAIASLKQQSTLQSLRIPKQPKYSLKQGNP 
               
               
                   
                   
                 VPLANLHEDVGRSSCSDFIDIDSEYKDPQMCTAYVTDIYANMRVVELKRRPLPN 
               
               
                   
                   
                 FMETTQRDINANMRSVLIDWLVEVSEEYKLVPDTLYLTVSYIDRFLSANVVNRQ 
               
               
                   
                   
                 RLQLLGVSCMLVASKYEEICAPPVEEFCYITDNTYKKEEVLEMEISVLNRLQYD 
               
               
                   
                   
                 LTTPTTKTFLRRFIRAAQASCKVSSLHLEFMGNYLAELTLVEYDFLKYLPSLIA 
               
               
                   
                   
                 AAAVFVARMTLDPMVHPWNSTLQHYTGYKVSDMRDCICAIHDLQLNRKGCTLAA 
               
               
                   
                   
                 IREKYNQPKFKCVANLFPPPIISPQFLIDNEV 
               
               
                   
               
               
                 398 
                 Cyclin B 
                 MAAPNQNALLINNNNRRPLVDIGNLVGALNAQCNISKNGARKRAFGDIGNLVED 
                 167 
                 1576 
               
               
                   
                   
                 LDAKCTISKYWVRKRPRTNFGVNANKGASSSTQGQGIVVRGEQKAWDRIVWGNK 
               
               
                   
                   
                 QSCAIKMNAQHVTATQRGTAISISDIIDSSVQDGGIKAPSQLKARKQTVRTVTA 
               
               
                   
                   
                 TLTARSEDSLRDVLEVPPGIDDGDRDNPLAVVEYVEDIYHFYRKIEVRSCVPPD 
               
               
                   
                   
                 YMTRQLEIKDSMRGVIIDWLIEVHRTFLLMPETLYLTVNIIDRYLSIQSVTRNE 
               
               
                   
                   
                 LQLMGITAMFIASKYEEISPPKINDLVYITKDAYTSKQIVNMEHTILNRLKFKL 
               
               
                   
                   
                 TVPTPYVFLVRFLKAAGPDKVMKNLAFFLVDLCLLHYKMIKYSPSMLAAAAVYT 
               
               
                   
                   
                 AQCTLKKHPYWNKTLILHIGYSEAHLRECAHLMADLHLKAEGSNLKSVYKKYSY 
               
               
                   
                   
                 PIFGSVAFLSPAKIPAGTVAAPAIDKCAHQIYLRNLR 
               
               
                   
               
               
                 399 
                 Cyclin B 
                 MFPNKQTQGLVQNKKMASKAAQPKAMVPPQRVPPAANNRRALGDIGNIVADVGG 
                 183 
                 1598 
               
               
                   
                   
                 KCNVTKDGVNGKPLAQVSRPITRSFGAQLLAQAAANKGISAANNQTQVPVVIPK 
               
               
                   
                   
                 ADVRGNKQRRTSKSKDIPPTTVVTNESDDCVIIEQAQRIKPTCNHNVGAVGNKE 
               
               
                   
                   
                 KPQLLTAKPKSLTASLTSRSAVALRGFRFDDEMTEAEEDPLPNIDVGDRDNQLA 
               
               
                   
                   
                 VVEYVEDIYKFYRRTEQMSCVPDYMPRQQEINPKMRAVLINWLIEVHYRFGLMP 
               
               
                   
                   
                 ETLYLTTNLIDRYLATQLVSRSNYQLVGATAMLLASKYEEIWAPEMNDFLDILE 
               
               
                   
                   
                 NKFERKHVLVMEKAMLNKLKFHLTVPTPYVFLVRFLKAAASDEEMENLVFFLME 
               
               
                   
                   
                 LSLMQYVMIKFPPSMLAAAAVYTAQITLKKTTVWNDVLKRHTGYSEIDLKECTR 
               
               
                   
                   
                 LMVAFHQSSEESKLNVVFKKYSMPEYDSVALIKPAKLPA 
               
               
                   
               
               
                 400 
                 Cyclin D 
                 MAPSFDCVANAYIESCEDQEKLRQNAQILAQSGENDVDEPVSMLVQRETHYMLP 
                 98 
                 1126 
               
               
                   
                   
                 EDYLQRLRNRTLDVNVRREAVGWILKVHSFYNFGAPTAYLAVNYLDRFLSRHRM 
               
               
                   
                   
                 PQGVKAWMIQLMAVACLSLAAKMEETQVPLPSDLQREDARFIFDARTIQRMELL 
               
               
                   
                   
                 ILSTLQWGMRSITPFSFIDYFAYRAVQGHGHGHDATPKAVMSRAIELILSTTEE 
               
               
                   
                   
                 IDFMEYRPSAIAAAALLCAAEEVVPLQAVHYKRALSSSITDVDKDKMFGCYNLI 
               
               
                   
                   
                 QETIIEGGCYWTPMSLQSTEKTPVGVLDAAACLSNTPTSSYSVKPYASVTAAKR 
               
               
                   
                   
                 RKLNEICSALLVSQAHPC 
               
               
                   
               
               
                 401 
                 Cyclin D 
                 MAANFWTSSHCKELLDAEKVGIVHPLDKDQGLTQEDVKIIKINMSNCIRTLAQY 
                 148 
                 894 
               
               
                   
                   
                 VKLRQRVVATAITYCRRVYTRKSFTEYDPQLVAPTCLYLASKAEESTVQAKLVI 
               
               
                   
                   
                 FYMKKYSKHRYEIKDMLEMEMKLLEALDYYLVIYHPYRPLIQFLQDAGLNDLKV 
               
               
                   
                   
                 TAWALVNDTYRTDLILTYPPYMIALACIYFACIMEEKDAQAWFEELRVDMNEIK 
               
               
                   
                   
                 NISMEIVDYYDNYRVIPDEKMNSALNKLPHRF 
               
               
                   
               
               
                 402 
                 Cyclin D 
                 MAPALSSSYECLSHLLCAEDASNVVGCWDEDESKIFCEEEEGFGIQHFPDFPVP 
                 287 
                 1363 
               
               
                   
                   
                 DDDEIRVLVRKESQYMPGKSYVQSYQNLGLDFTARQNAIGWILKVHGSYNFGPL 
               
               
                   
                   
                 TAYLSINYLDRFLSRNPLPKAKVWMLQLLSVACLSLAAKMEETQVPLLLDLQAE 
               
               
                   
                   
                 EPDFLFEPRTIQRMELLVLSTLEWRMLSVTPFSFVDYFLQGGGGRKPPPRAMVA 
               
               
                   
                   
                 RANELIFNTHTVLDFLEHRPSAIAAAAVICAAEEVLPLEAAQYKETILSCSLVD 
               
               
                   
                   
                 KEWVFGSYNLIQEVLIEKFSTPKKAKSASSSIPQSPVGVLDAFCLSNNSNNTSL 
               
               
                   
                   
                 EASLSVNLYASVAAKRRKLNDYCNTWRMFQHSTC 
               
               
                   
               
               
                 403 
                 Cyclin D 
                 MAPNCIDCAPSDLFCAEDAFGVVEWGDAETGSLYGDEDQLHYNLDICDQHDEHL 
                 251 
                 1348 
               
               
                   
                   
                 WDDGELVAFAEKETLYVPNPVEKNSAEAKARQDAVDWILKVHAHYGFGPVTAVL 
               
               
                   
                   
                 SINYLDRFLSANQLQQDKPWMTQLAAVACLSLAAKMDETEVPLLLDFQVEEAKY 
               
               
                   
                   
                 IFESRTIQRMELLVLSTLEWRMSPVTPLSYIDHASRMIGLENHHCWIFTMRCKE 
               
               
                   
                   
                 ILLNTLRDAKFLGLLPSVVAAAIMLHVIKETELVNPCEYENRLLSAMKVNKDMC 
               
               
                   
                   
                 ERCIGLLIAPESSSLGSFSLGLKRKSSTINIPVPGSPDGVLDATFSCSSSSCGS 
               
               
                   
                   
                 GQSTPGSYDSNNSSILCISPAVIKKRKLNYEFCSDLHCLED 
               
               
                   
               
               
                 404 
                 Cyclin- 
                 MPQIQYSEKYTDDTYEYRHVVLPPETAKLLPKNRLLNENEWRAIGVQQSRGWVH 
                 229 
                 510 
               
               
                   
                 dependent 
                 YAIHRPEPHIMLFRRPLNYQQNQQQQAGAQSQPMGLKAQ 
               
               
                   
                 kinase 
               
               
                   
                 regulatory 
               
               
                   
                 subunit 
               
               
                   
               
               
                 405 
                 Cyclin- 
                 MDQIEYSEKYYDDTYEYRHVELPPDVARLLPKNRLLTENEWRGIGVQQSRGWVH 
                 92 
                 409 
               
               
                   
                 dependent 
                 YAIHCSEPHIMLFRRPLNYEQNHQHPEPHIMLFRRPLNCQPNHQPQAHHPT 
               
               
                   
                 kinase 
               
               
                   
                 regulatory 
               
               
                   
                 subunit 
               
               
                   
               
               
                 406 
                 Cyclin- 
                 MDQIEYSEKYYDDTYEYRHVELPPDVARLLPKNRLLTENEWRGIGVQQSRGWVH 
                 64 
                 381 
               
               
                   
                 dependent 
                 YAIHCSEPHIMLFRRPLNYEQNHQHPEPHIMLFRRPLNCQPNHQPQAHHPT 
               
               
                   
                 kinase 
               
               
                   
                 regulatory 
               
               
                   
                 subunit 
               
               
                   
               
               
                 407 
                 Cyclin- 
                 MPQIQYSEKYYDDTYEYRHVVLPPDVARLLPKNRLLNENEWRGIGVQQSRGWVH 
                 68 
                 349 
               
               
                   
                 dependent 
                 YAIHRPEPHIMLFRRHLNYQQNQQQQAQQQPAQAMGLQA 
               
               
                   
                 kinase 
               
               
                   
                 regulatory 
               
               
                   
                 subunit 
               
               
                   
               
               
                 408 
                 Histone 
                 MALVETEPVTLIHPEEPKKFKKKPTPGRGGVISHGLTEEEARVKAIAEIVGAMV 
                 125 
                 1849 
               
               
                   
                 acetyltransferase 
                 EGCRKGEDVDLNALKAAACRRYGLSRAPKLVEMIAALPDGERAAVLPKLKAKPV 
               
               
                   
                   
                 RTASGIAVVAVMSKPHRCPHIATTGNICVYCPGGPDSDFEYSTQSYTGYEPTSM 
               
               
                   
                   
                 RAIRARYNPYVQTRSRIDQLKRLGHTVDKVEFILMGGTFMSLPADYRDYFIRNL 
               
               
                   
                   
                 HDALSGHTSSNVEEAVCYSEHSATKCTGLTIETRPDYCLGPHLRQMLSYGCTRL 
               
               
                   
                   
                 EIGVQSTYEDVARDTNRGHTVAAVADCFCLAKDAGFKVVAHMMPDLPNVGVERD 
               
               
                   
                   
                 MESFREFFENPAFRADGLKIYPTLVIRGTGLYELWKTGRYRNYPPEQLVDIIAR 
               
               
                   
                   
                 VLALVPPWTRVYRVQRDIPMPLVTSGVEKGNLRELALARMDDLGLKCRDVRTRE 
               
               
                   
                   
                 AGIQDIHHKIRPEVVELVRRDYCANEGWETFLSYEDTRQDILVGLLRLRKCGHN 
               
               
                   
                   
                 TTCPELKGRCSIVRELHVYGTAVPVHGRDADKLQHQGYGTLLMEQAERIAWKEH 
               
               
                   
                   
                 RSIKIAVISGVGTRHYYRKLGYELEGPYMMKYLN 
               
               
                   
               
               
                 409 
                 Histone 
                 MLGFRDLYTSICEHLQRASGRLPIIAAATSLISTPEIAAVEKENKAPNSVDKMG 
                 70 
                 1602 
               
               
                   
                 acetyltransferase 
                 MGSADESGRFSTSNGQFMNMNNGVVKEEWKGGVPVVPSAPTTVPVITNVKLETP 
               
               
                   
                   
                 SSPDHDMARKRKLGFLPLEVGTRVLCKWRDGKFHPVKIIERRKLPNGATNDYEY 
               
               
                   
                   
                 YVHYTEFNRRLDEWVKLEQLELDSVETDADEKVDDKAGSLKMTRHQKRKIDETH 
               
               
                   
                   
                 VEGNEELDAASLREHEEFTKVKNITKIELGRYEIETWYFSPFPSEYNNCEKLYF 
               
               
                   
                   
                 CEFCLNFMKRKEQLQRHMRKCDLKHPPGDEIYRSGTLSMFEVDGKKNKVYAQNL 
               
               
                   
                   
                 CYLAKLFLDHKTLYYDVDLFLFYILCECDERGCHMVGYFSKEKHSEESYNLACI 
               
               
                   
                   
                 LTLPPYQRKGYGKFLISFSYELSKKEGKVGTPERPLSDLGLLSYRGYWTRVLLD 
               
               
                   
                   
                 ILKKHKSNISIKELSDMTAIKADDVLSTLQGLDLIQYRKGQHAICADPKVLDRH 
               
               
                   
                   
                 LKAVGRGGLEVDVCKLIWTPYKEQ 
               
               
                   
               
               
                 410 
                 Histone 
                 MGSLDESTCSEEIRDEGKDSIRTKFKVESTVNNAQNGGNDNSKKKRAAGLPLEV 
                 140 
                 1465 
               
               
                   
                 acetyltransferase 
                 GIRLLCKWRDSKLHPVKIIERRKLPNGFPQDYEYYVHYTEFNRRLDEWVKLEQF 
               
               
                   
                   
                 ELDSVETDADEKIEDKGGSLKMTRHQKRKIDEIHVEEGQGHEDFDPASLREHEE 
               
               
                   
                   
                 FTKVKNIAKVELGRYEIETWYFSPFPPEYSHCEKLFFCEFCLNFMKRKEQLQRH 
               
               
                   
                   
                 MRKCDLKHPPGDEIYRNGTLSMFEVDGKKNKIYGQNLCYLAKLFLDHKTLYYDV 
               
               
                   
                   
                 DLFLFYVLCECDDRGCHVVGYFSKEKHSDEAYNLACILTLPPYQRKGYGKFLIA 
               
               
                   
                   
                 FSYELSKKEGKVGTPERPLSDLGLLSYRGYWTRILLDILKKQRGNISIKELSDM 
               
               
                   
                   
                 TAIKVEDVISTLQVLDLIQYRKGQHVICADPKVLDRHLKAAGIAGLEVDVSKLI 
               
               
                   
                   
                 WTPYKEQCG 
               
               
                   
               
               
                 411 
                 Histone 
                 MASAPMVGCDDSRDKHRWVESKVYMRKGHGKGSKGNAGFNAQNSTAQVRRENDN 
                 628 
                 2565 
               
               
                   
                 acetyltransferase 
                 MGNSIADNGKSEAASEGLSSLSRKQITVNQDHPPNETSSMPAVGGLQNIDTHVT 
               
               
                   
                   
                 FKLEGCSKQEIWELRKKLTNELEQVRGTFKKLEARELQLRGYSVSAGVNTSYSA 
               
               
                   
                   
                 SQFSGNDMRNNGGKEVTSEVASGGAITPKQAQRESNPPRQLSISLMENNQAASD 
               
               
                   
                   
                 MGEKGKRTPKANQYYRNSEFVLGKDKFPPAESKKSKSTGNKKISQSKVFSKETM 
               
               
                   
                   
                 QVGKEFMPQKSVNEVFKQCSLLLTKLMKHKYGWVFNLPVDAQALGLHDYHTIIK 
               
               
                   
                   
                 RPMDLGTVKSKLEKNLYNSPASFAEDVKLTFSNAMTYNPKGHEVHTMAEQLLQL 
               
               
                   
                   
                 FEERWKTIYEEHLDGKMRFGSGQGLGASSSTKKLPFQDSKKNIKKSEPAGGPSP 
               
               
                   
                   
                 PKPKSTNHHASRTPSAKKPKAKDPHKRDMTYEEKQKLSTNLQNLPQERLELIVQ 
               
               
                   
                   
                 IIKKRNPSLCQHDEEIEVDIDSFDTETLWELDRFVTNYKKSLSKNKKKALLADQ 
               
               
                   
                   
                 AKRASEHGSARNKHPMIGRELPMNNKKGEQGEKVVEIDHMPPVNPPVVEVEKDG 
               
               
                   
                   
                 VYAKRSSSSSSSSSDSGSSSSDSDSGSSSGSESDAYAATSPPAGSNTSARG 
               
               
                   
               
               
                 412 
                 Histone 
                 MEGHSGALGFGQGFSRSSQSPNLSPSPSHSASASVTSSGQKRKRNEVEHAGVAS 
                 55 
                 1818 
               
               
                   
                 acetyltransferase 
                 NSTGMFAVPPSHIYSHLHPMSMSMPMPMHNSHPSSLSESRDGALTSNDDDDNLT 
               
               
                   
                   
                 GGNQSQLDSMSAGNTDGREDFDDEDDDDDDEEDDDEVEGDEEDQDHDPDADDDS 
               
               
                   
                   
                 DDGHDSMRTFTAARLDNGAPNSRNLKPKADAAGVAIAPTVKTEPILDTVKEEKV 
               
               
                   
                   
                 SGNNNNNSVSANNAQVAPSGSAVLLSAVKEEANKPTSTDHIQTSGAYCAREESL 
               
               
                   
                   
                 KREEDADRLKFVCFGNDGIDQHMIWLIGLKNIFARQLPNMPKEYIVRLVMDRSH 
               
               
                   
                   
                 KSVMIIKQNQVVGGITYRPYLSQKFGEIAFCAITADEQVKGYGTRLMNHLKQHA 
               
               
                   
                   
                 RDVDGLTHFLTYADNNAVGYFIKQDFTKEIKLEKERWHGYIKDYDGGILMECKI 
               
               
                   
                   
                 DPKLPYTDLPAMIRWQRQTIDEKIRELSNCHIVYSGIDIQKKEAGIPRKPIKVE 
               
               
                   
                   
                 DIPGLKEAGWTTDQWGHSRFRLLNSPSEGLPNRQVLHAFMRSLHKAMVEHADAW 
               
               
                   
                   
                 PFKEPVDPRDVPDYYDIIKDPMDVKRMFTNARTYNTHETIYYKCANR 
               
               
                   
               
               
                 413 
                 Histone 
                 MEESGNSLTSGPDGSKRRVSYFYDSDIGNYYYSQGHPMKPHRIRMAHSLIVHYA 
                 259 
                 1710 
               
               
                   
                 deacetylase 
                 LDEKMEVCRPNLLQSRELRVFHADDYISFLQSVTPETQHEQLRQLKRFNVGEDC 
               
               
                   
                   
                 PVFDGLYNFCQTYAGGSVGAAIKLNNKEADIAINWSGGLHHAKKCEASGFCYVN 
               
               
                   
                   
                 DIVLAILELLKVHQRVLYIDIDIHHGDGVEEAFYSTDRVMSVSFHKFGDYFPGT 
               
               
                   
                   
                 GHLKDVGYGKGKYYSLNVPLNDGIDDESYKNLFRPIIQKVMEIYQPEAVVLQCG 
               
               
                   
                   
                 ADSLSGDRLGCFNLSVKGHADCVRFLRSFNVPLVLVGGGGYTIRNVARCWCYET 
               
               
                   
                   
                 AVAVGVEPQDKLPYNEYYEYFGPDYTLHVAPSNMENQNSAKELAKIRNTLLEQL 
               
               
                   
                   
                 KRIQHVPSVPFQERPPDTKFPEEDEEDYEKRPKGHKWGGEYFGSESDEEQKPQN 
               
               
                   
                   
                 RDIDISDKPGIRRQSPPNVEAAKKIKVEEEDGDIGIVNENDGAKWPLGEAG 
               
               
                   
               
               
                 414 
                 Histone 
                 MEESGNSLTSGPDGSKRRVSYFYDSDIGNYYYSQGHPMKPHRIRMAHSLIVHYA 
                 356 
                 1807 
               
               
                   
                 deacetylase 
                 LDEKMEVCRPNLLQSRELRVFHADDYISFLQSVTPETQHEQLRQLKRFNVGEDC 
               
               
                   
                   
                 PVFDGLYNFCQTYAGGSVGAAIKLNNKEADIAINWSGGLHHAKKCEASGFCYVN 
               
               
                   
                   
                 DIVLAILELLKVHQRVLYIDIDIHHGDGVEEAFYSTDRVMSVSFHKFGDYFPGT 
               
               
                   
                   
                 GHLKDVGYGKGKYYSLNVPLNDGIDDESYKNLFRPIIQKVMEIYQPEAVVLQCG 
               
               
                   
                   
                 ADSLSGDRLGCFNLSVKGHADCVRFLRSFNVPLVLVGGGGYTIRNVARCWCYET 
               
               
                   
                   
                 AVAVGVEPQDKLPYNEYYEYFGPDYTLHVAPSNMENQNSAKELAKIRNTLLEQL 
               
               
                   
                   
                 KRIQHVPSVPFQERPPDTKFPEEDEEDYEKRPKGHKWGGEYFGSESDEEQKPQN 
               
               
                   
                   
                 RDIDISDKPGIRRQSPPNVEAAKKIKVEEEDGDIGIVNENDGAKWPLGEAG 
               
               
                   
               
               
                 415 
                 Histone 
                 MEFWGVEVKPGEALTCDPGDERYLHMSQAAIGDKEGAKENERVSLYVHVDGKKF 
                 261 
                 1298 
               
               
                   
                 deacetylase 
                 VLGTLSRGKCDQIGLDLVFEKEFKLSHTSQTGSVFVSGYTTVDHEALDGFPDDE 
               
               
                   
                   
                 DLESSEDEEEELAQITTLTAKENGGKTGAKPVKPESKSSVTDKAAAKGKPEVKP 
               
               
                   
                   
                 PVKKQEDDSDSDEDEDEDEDEDEDDDDEDDEDMKDASASDDGDEEDDSDEESDD 
               
               
                   
                   
                 DEEEDEETPKPAAGKKRPMPASDNKSPATDKKAKITTPAGGQKPGADKGKKTEH 
               
               
                   
                   
                 IATPYPKHGAKGPASGVKGKETPLGSKQTPGSKVKNSSTPESGKKSGQFKCQSC 
               
               
                   
                   
                 SRDFATEGALSSHNAAKHGGK 
               
               
                   
               
               
                 416 
                 Histone 
                 MMETGGNSLPSGPDGVKRKVAYFYDPEVGNYYYGQGHPMKPHRIRMTHALLVQY 
                 365 
                 2251 
               
               
                   
                 deacetylase 
                 GLHKEMQILKPYPARDRDLCRFHADDYVAFLRGITPETIQDQVKALKRFNVGDD 
               
               
                   
                   
                 CPVFDGLYQYCQTYAGGSVGGAVKLNHKLCDIAINWAGGLHHAKKCEASGFCYV 
               
               
                   
                   
                 NDIVLAILELLKYHKRVLYVDIDIHHGDGVEEAFYTTDRVMTVSFHKFGDYFPG 
               
               
                   
                   
                 TGDIRDIGCGKGKYYAVNVPLDDGIDDESFQSLFKPIIQQVMLVYNPEAIVLQC 
               
               
                   
                   
                 GADSLSGDRLGCFNLSVKGHAECVRYMRSFNVPLLMVGGGGYTVRNVARCWCYE 
               
               
                   
                   
                 TGVAVGVEIDDKMPQHEYYEYFGPDYTVHVAPSNMENKNTKQYLDKIRSKILEN 
               
               
                   
                   
                 INSLPCAPSAQFQVQPPDTDFPELEEEDYDERTRSHKWDGASCDSDSENGDLKH 
               
               
                   
                   
                 RNHDVEESAFPRHNLANISYNTKIKLEGVGTGGLDMAAGTDTKKNDESFEAMDY 
               
               
                   
                   
                 ESGEELRQDHFASTINASQPCDPALLTGVQNQLQSTDTVKPIEQSGNAPGIPPP 
               
               
                   
                   
                 SVATVSTGTRPSSISRTSSLNSMSSVKQGSILGPNPPQGLNASGLQFPVPTSNS 
               
               
                   
                   
                 PIRQGGSYSITVQAPDKQGLQNHMKGPQNMPGNS 
               
               
                   
               
               
                 417 
                 Histone 
                 MPPKDRVAYFYDGDVGSVYFGPNHPMKPHRLCMTHHLVLSYELHKKMEIYRPHK 
                 156 
                 1454 
               
               
                   
                 deacetylase 
                 AYPVELAQFHSADYVEFLHRITPDTQHLFTKELVKYNMGEDCPVFENLFEFCQI 
               
               
                   
                   
                 YAGGTIDAAHRLNNQICDIAINWSGGLHHAKKCEASGFCYINDLVLGILELLKH 
               
               
                   
                   
                 HARVLYVDIDVHHGDGVEEAFYFTDRVMTVSFHKYGDMFFPGTGDVKEVGEREG 
               
               
                   
                   
                 KYYAINVPLKDGIDDASFTRLFKTIITKVVDIYQPGAIVLQCGADSLAGDRLGC 
               
               
                   
                   
                 FNLSIDGHAQCVRIVKKFNLPLLVTGGGGYTKENVARCWSVETGVLLDTELPNE 
               
               
                   
                   
                 IPDNDYIKYFAPDYSLKINTAGNMENLNSKTYLSAIKVQVMENLRAIQHAPSVQ 
               
               
                   
                   
                 MHEVPPDFYIPDIDEDELNPDERMDQHTQDRQIQRDDEYYDGDNDIDHDMEEAS 
               
               
                   
               
               
                 418 
                 Histone 
                 MDSSKSEEANILHVFWHEGMLNHDLGTGVFDTLEDPGFLEVLEKHPENADRVRN 
                 203 
                 1348 
               
               
                   
                 deacetylase 
                 MLSILRKGPIAPYTEWHTGRAAYLSELYSFHRPDYVDMLAKTSTAGGKTLCHGT 
               
               
                   
                   
                 RLNPGSWEAALLAAGTTLEAMRYILDGHGKLSYALVRPPGHHAQPTQADGYCFL 
               
               
                   
                   
                 NNAGLAVELAVASGCKRVAVVDIDVHYGNGTAEGFYERDDVLTISLHMNHGSWG 
               
               
                   
                   
                 PSHPQTGFHDEVGRGKGLGFNLNVPLPNGTGDKGYEHAMHELVVPAISKFMPEM 
               
               
                   
                   
                 IVLVIGQDSSAFDPNGRECLTMEGYRKIGQIMRQQADQFSGGRLVVVQEGGYHI 
               
               
                   
                   
                 TYAAYCLHATLEGVLCLPHPLLSDPIAYYPEHDIYSERVTFIKNYWQGIISTTD 
               
               
                   
                   
                 KRN 
               
               
                   
               
               
                 419 
                 Histone 
                 MEESGNALVSGPDGSKRRVTYFYDADIGNYYYGQGHPMKPHRMRMAHNLIVHYG 
                 229 
                 1644 
               
               
                   
                 deacetylase 
                 LHQRMEVCRPHLAQSKDIRAFHTDDYIHFLSSVAPDTQQEQLRQLKRFNVGEDC 
               
               
                   
                   
                 PVFDGLFNFCQSSAGGSIGAALKLNRKDADIAINWAGGLHHAKKCEASGFCYVN 
               
               
                   
                   
                 DIVLGILELLKVHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKFGDYFPGT 
               
               
                   
                   
                 GHIKDVGYGKGKYYALNVPLNDGIDDESYKHLFRPIIQKVMEVYQPEAVVLQCG 
               
               
                   
                   
                 ADSLSGDRLGCFNLSVKGHADCVRFVRSFNIPLMLVGGGGYTIRNVARCWCYET 
               
               
                   
                   
                 AVAVGVEPQDKLPYNEYYEYFGPDYTLYVAPSNMENLNTEKDLEKMRNVLLEQL 
               
               
                   
                   
                 SKIQHTPSVPFQERPPDTEFNDEEEEDMEKRSKCRIWDGEYVGSEPEEDGKLPR 
               
               
                   
                   
                 FDADTYERSVLKHENKRLVPVSNVEPLKRIKQEEDGAAV 
               
               
                   
               
               
                 420 
                 Histone 
                 MPPKDRVAYFYDGDVGSVYFGPNHPMKPHRLCMTHHLVLSYELHKKMEIYRPHK 
                 156 
                 1454 
               
               
                   
                 deacetylase 
                 AYPVELAQFHSADYVEFLHRITPDTQHLFTKELVKYNMGEDCPVFENLFEFCQI 
               
               
                   
                   
                 YAGGTIDAAHRLNNQICDIAINWSGGLHHAKKCEASGFCYINDLVLGILELLKH 
               
               
                   
                   
                 HARVLYVDIDVHHGDGVEEAFYFTDRVMTVSFHKYGDMFFPGTGDVKEVGEREG 
               
               
                   
                   
                 KYYAINVPLKDGIDDASFTRLFKTIITKVVDIYQPGAIVLQCGADSLAGDRLGC 
               
               
                   
                   
                 FNLSIDGHAQCVRIVKKFNLPLLVTGGGGYTKENVARCWSVETGVLLDTELPNE 
               
               
                   
                   
                 IPDNDYIKYFAPDYSLKINTAGNMENLNSKTYLSAIKVQVMENLRAIQHAPSVQ 
               
               
                   
                   
                 MHEVPPDFYIPDIDEDELNPDERMDQHTQDRQIQRDDEYYDGDNDIDHDMEEAS 
               
               
                   
               
               
                 421 
                 Histone 
                 MDLNLVSHGEEEEGVRRRKVGIVYDERMCKHATPEDQPHPEQPDRIRVIWDKLN 
                 27 
                 2222 
               
               
                   
                 deacetylase 
                 SAGVLHKCVMVEAKEASEEQLAGVHSRKHIEVMKSIGTARYNKKKRDKLAASYS 
               
               
                   
                   
                 SIYFSQGSSEAALLAAGSVVEISEKVASGELDAGVAIVRPPGHHAEADKAMGFC 
               
               
                   
                   
                 LFNNIAIAAKHLVHERPELGVQEVLIVDWDVHHGNGTQHMFWTDPHVLYFSVHR 
               
               
                   
                   
                 FDAGTFYPGGDDGFYDKIGEGKGAGYNINVPWEQGKCGDADYLAVWDHVLVPVA 
               
               
                   
                   
                 KSYDPDMVLISGGFDAALGDPLGGCRLTPYGYSLMTKKLMEFAGGKIVLALEGG 
               
               
                   
                   
                 YNLKSLADSFLACVEALLKDGPSRSSVLTHPFGSTWRVIQAVRKELSSFWPALN 
               
               
                   
                   
                 EELQLPRLLKDASESFDKLSSSSSDESSASEDEKKIAEVTSIMEVSPDPSSILA 
               
               
                   
                   
                 LTAEDIAQPLAGLKIEEAGTDSQRSSDHTLLDLTNDDTQKLKQFEGEIFVMIGD 
               
               
                   
                   
                 EESVPSASSSKDQNESTVVLSKSNIKAHSWRLTFSSIYVWYASYGSNMWNPRFL 
               
               
                   
                   
                 CYIEGGQVEGMAKRCCGSEDKTPPQRIQWKVVPHRMFFGRSYTNTWGSGGVSFL 
               
               
                   
                   
                 DPNCSDTSEAHVCLYKITLAQFNDLLLQENNLNCGTEHPLVDLSSIDAIRNGNS 
               
               
                   
                   
                 ILELIKDSWYGTLIYLGMEGGLPIVTFTCSVCDVEKFKHGQLPLCPPSSRYENI 
               
               
                   
                   
                 LIRGLVQGKKLSEDDATAYIRAASTSPLL 
               
               
                   
               
               
                 422 
                 Peptidylprolyl 
                 MADEDLDLSDVGEVEDEPGEEIESTPPLAVGQEKEINSLALKKKLLKVGTRWET 
                 71 
                 1759 
               
               
                   
                 isomerase 
                 PENGDEVTVHYTGTLPDGTKFDSSRDRGEPFTFKLGQGQVIKGWDQGIVTMKKG 
               
               
                   
                   
                 ERALFTIPPELAYGSSGVRPTIPPNATLQFDVELLSWTNIVDVCNDGGILKRII 
               
               
                   
                   
                 SEGEKYERPKDPDEVTVKYEAKLEDGTLVAKSPEEGVEFYVNDGHFCPAIAKAV 
               
               
                   
                   
                 KTMKRGESVILTIKPTYAFGERGKDAEEGFAAIPPNATLTTSLELVSFKAVIAV 
               
               
                   
                   
                 TEDKKVIKKILKEADGYDKPSDGTVVQIRYTAKLQDGTIFEKKGYEGEEPFQFV 
               
               
                   
                   
                 VDEEQVIAGLDKAVETMKTGEIALITIGAEYGFGNFETQRDLAVIPPNSTLIYE 
               
               
                   
                   
                 VEMISFTKEKESWDMDTTEKIEASKQKKEQGNSLFKVGKYQRAAKKYEKAAKYI 
               
               
                   
                   
                 EHDSSFSAEEKKQSKVLKVSCNLNHAACRLKLKDFKEAVKLCSKVLELESQNVK 
               
               
                   
                   
                 ALYRRAQAYIETADLDLAEFDIKKALEIEPQNREVQLEYKILKQKQIEYNKKDA 
               
               
                   
                   
                 KLYGNMFAKLNKLEAFEGKVLS 
               
               
                   
               
               
                 423 
                 Peptidylprolyl 
                 MADEGLELSDVAEVEDEPGEEFESAPPLVVGQEKELNSSGLKKKLLKAGTRCET 
                 358 
                 2040 
               
               
                   
                 isomerase 
                 PENGDEVTVHYTGTLLDGTKFDSSRDRGEPFTFNIGQGQVIKGWDQGIVTMKKR 
               
               
                   
                   
                 EHALFTIPPELAYGASGMPPTIPPNATLQFDVELLSWTNIVDVCKDGGILKRII 
               
               
                   
                   
                 SDGEKYERPKDPDEVTVKYEAKLEDGMLVAKSPEEGVEFYVNDGNFCPAIVKAV 
               
               
                   
                   
                 KTMKKGENVTLTIKPAYAFGEQGKDAEEGFAAIPPNATITINLQLVSFKAVKEV 
               
               
                   
                   
                 TEDKKVIKKILKEADGYDKPSDGTVVQIRYTAKLQDGTIFEKKGYAGEEPFQFV 
               
               
                   
                   
                 VDEEQVIAGLDKAVETMKTGEVALITIGPEYGFGNIETQRDLAVIPPYSTLIYE 
               
               
                   
                   
                 VEMVSFTKEKESWDMNTTENIEASKQKKEQGNSLFKVGKYLRAAKKYDKAAKYI 
               
               
                   
                   
                 EHDNSFSAEEKKQSKVLKVSCNLNHAACCLKLKDFKKAVKLCSKVLELESQNVK 
               
               
                   
                   
                 ALYRRAQAYIETADLDLAEFDIKKALEIEPQNREVRLEYLILKQKQIEYNKKDA 
               
               
                   
                   
                 KLYGNMFARQNKLEAIEGKD 
               
               
                   
               
               
                 424 
                 Peptidylprolyl 
                 MPNPKVFFDMQVGGAPAGRIVMELYADVVPKTAENFRALCTGEKGTGRSGKPLH 
                 238 
                 756 
               
               
                   
                 isomerase 
                 FKGSSFHRVIPGFMCQGGDFTRGNGTGGESIYGEKFADENFVKKHTGPGILSMA 
               
               
                   
                   
                 NAGPNTNGSQFFICTAQTSWLDGKHVVFGQVVEGLEVVRDIEKVGSGSGRTSKP 
               
               
                   
                   
                 VVIADSGQLA 
               
               
                   
               
               
                 425 
                 Peptidylprolyl 
                 MPNPKVFFDMQVGGAPAGRIVMELYADVVPKTAENFRALCTGEKGNGRSGKPLH 
                 238 
                 756 
               
               
                   
                 isomerase 
                 FKGSSFHRVIPGFMCQGGDFTRGNGTGGESIYGEKFADENFVKKHTGPGILSMA 
               
               
                   
                   
                 NAGPNTNGSQFFICTAQTSWLDGKHVVFGQVVEGLEVVRDIEKVGSGSGRTSKP 
               
               
                   
                   
                 VVIADSGQLA 
               
               
                   
               
               
                 426 
                 Peptidylprolyl 
                 MPNPKVFFDMQVGGAPAGRIVMELYADVVPKTAENFRALCTGEKGTGRSGKPLH 
                 238 
                 756 
               
               
                   
                 isomerase 
                 FKGSSFHRVIPGFMCQGGDFTRGNGTGGESIYGEKFADENFVKKHTGPGILSMA 
               
               
                   
                   
                 NAGPNTNGSQFFICTAQTSWLDGKHVVFGQVVEGLEVVRDIEKVGSGSGRTSKP 
               
               
                   
                   
                 VVIADSGQLA 
               
               
                   
               
               
                 427 
                 Peptidylprolyl 
                 MPNPKVFFDMQVGGAPAGRIVMELYADVVPKTAENFRALCTGEKGTGRSGKPLH 
                 238 
                 756 
               
               
                   
                 isomerase 
                 FKGSSFHRVIPGFMCQGGDFTRGNGTGGESIYGEKFADENFVKKHTGPGILSMA 
               
               
                   
                   
                 NAGPNTNGSQFFICTAQTSWLDGKHVVFGQVVEGLEVVRDIEKVGSGSGRTSKP 
               
               
                   
                   
                 VVIADSGQLA 
               
               
                   
               
               
                 428 
                 Peptidylprolyl 
                 MADDFELPESAGMMENEDFGDTVFKVGEEKEIGKQGLKKLLVKEGGSWETPETG 
                 176 
                 1912 
               
               
                   
                 isomerase 
                 DEVEVHYTGTLLDGTKFDSSRDRGTPFKFKLGQGQVIKGWDQGIATMKKGENAV 
               
               
                   
                   
                 FTIPPDLAYGESGSQPTIPPNATLKFDVELLSWASVKDICKDGGIFKKIIKEGE 
               
               
                   
                   
                 KWEHPKEADEVLVKYEARLEDGTVVSKSEEGVEFYVKDGYFCPAFAIAVKTMKK 
               
               
                   
                   
                 GEKVLLTVKPQYGFGHQGREAIGNDVARSTNATLLVDLELVSWKVVDEVTDDKK 
               
               
                   
                   
                 VLKKILKQGEGYERPNDGAVVKVKYTGKLEDGTIFEEKGSDEEPFEFMAGEEQV 
               
               
                   
                   
                 VDGLDRAVMTMKKGEVALVSVAAEYGYQTEIKTDLAVVPPKSTLIYEVELVSFV 
               
               
                   
                   
                 KEKESWDMNTAEKIEAAGKKKEEGNALFKVGKYFRASKKYEKATKYIEYDTSFS 
               
               
                   
                   
                 EEEKKQSKPLKVTCNLNNAACKLKLKDYTQAEKLCTKVLEVESQNVKALYRRAQ 
               
               
                   
                   
                 AYIQTADLELAELDIKKALEIDPNNRDVKLEYRALKEKQKEYNKKEAKFYGNMF 
               
               
                   
                   
                 ARMSKLEELESRKSGSQKVETANKEEGSDAMAVDGESA 
               
               
                   
               
               
                 429 
                 Peptidylprolyl 
                 MAASLTPLGAGLAYATIYDQAKVRKLEPTKRSLIALCQHSDSQHRRFITRKYHV 
                 64 
                 765 
               
               
                   
                 isomerase 
                 NVQILNRRDAIRLIGLAAGLCIDLSLMYDARGAGLPPQENAKLCDTTCEKELEN 
               
               
                   
                   
                 APMITTESGLQYKDIKIGNGPSPPIGFQVAANYVAMVPSGQVFDSSLDKGQPYI 
               
               
                   
                   
                 FRVGSGQVIKGLDEGLLSMKVGGKRRLYIPGPLAFPKGLNSAPGRPRVAPSSPV 
               
               
                   
                   
                 IFDVSLEFIPGLESEEE 
               
               
                   
               
               
                 430 
                 Peptidylprolyl 
                 MSAASLSADMAIRGTILGKTALHVLGPQVVSQCRQPVMFKCPPHTLRKMRFSAQ 
                 93 
                 881 
               
               
                   
                 isomerase 
                 DLQSKNFYSGFTPFKSVFISTSKRSWQAGSARAMSQDAAFQSKVTTKCFLDIEI 
               
               
                   
                   
                 GGDPAGRIVLGLFGEDVPKTAENFRALCTGEKGFGYKGSSFHRIIKDFMLQGGD 
               
               
                   
                   
                 FDRGDGTGGKSIYGRTFEDENFKLAHVGPGVLSMANAGPNTNGSQFFICTVKTP 
               
               
                   
                   
                 WLDKRHVVFGQVIEGMEIVKKLESEETNRTDRPKRPCRIVDCGELP 
               
               
                   
               
               
                 431 
                 Peptidylprolyl 
                 MGRIKPQTLLQQSKKKKVPGRISVSTIIVCNLIIIFLMFSLVGIYRQRAKRNRA 
                 372 
                 1070 
               
               
                   
                 isomerase 
                 TSRSDGDEEMENFGRSKINSVPHQAIVNTTKGLITLELFGKSSAHTVEKFVEWS 
               
               
                   
                   
                 ERGYFNGLPFYRVIKHFVIQVGDPKFAGNREDWTVGGQLNVQLEFSPKHEAFML 
               
               
                   
                   
                 GTSKLEDQGDGFELFITTAPIPDLNDKLNVFGRVIKGQDVVQEIEEVDTDEHFQ 
               
               
                   
                   
                 PKSPIIINDVRLKDEL 
               
               
                   
               
               
                 432 
                 Peptidylprolyl 
                 MARQSTLLLFWSLVFLGAIVFTQAKHEELEEVTHKVYFDVDIAGKPAGRVVIGL 
                 28 
                 594 
               
               
                   
                 isomerase 
                 FGKAVPKTVENFRALCTGEKGVGKSGKPLHYKGSFFHRIIPSFMIQGGDFTLGD 
               
               
                   
                   
                 GRGGESIYGTKFADENFKLKHTGPVFITTVTTDWLDGRHVVFGKIISGMDVVYK 
               
               
                   
                   
                 VEAEGRQSGQPKRKVKIADSGELSMD 
               
               
                   
               
               
                 433 
                 Peptidylprolyl 
                 MARQSTLLLFWSLVFLGAIVFTQAKHEELEEVTHKVYFDVDIAGKPAGRVVIGL 
                 34 
                 648 
               
               
                   
                 isomerase 
                 FGKAVPKTVENFRALCTGEKGVGKSGKPLHYKGSFFHRIIPSFMIQGGDFTLGD 
               
               
                   
                   
                 GRGGESIYGTKFADENFKLKHTGPGFLSMANAGPDTNGSQFFITTVTTDWLDGR 
               
               
                   
                   
                 HVVFGKIISGMDVVYKVEAEGRQSGQPKRKVKIADSGELSMD 
               
               
                   
               
               
                 434 
                 Peptidylprolyl 
                 MEMDEIQEQSQPQSSEKQDISQESDTGNDKTINAEKITSENAEVEEDDMLPPKV 
                 481 
                 1611 
               
               
                   
                 isomerase 
                 NTEVEVLHDKVTKQIIKEGSGNKPSRNSTCFLHYRAWAESTMHKFQDTWQEQQP 
               
               
                   
                   
                 LELVLGREKKELSGFAIGVAGMKAGERALLHVDWQLGYGEEGNFSFPNVPPRAN 
               
               
                   
                   
                 LIYEAELIGFEEAKEGKARSDMTVEERIEAADRRRQQGNELFKEDKLAEAMQQY 
               
               
                   
                   
                 EMALAYMGDDFMFQLFGKYKDMANAVKNPCHLNMAQCLLKLNRYEEAIGQCNMV 
               
               
                   
                   
                 LAEDEKNIKALFRRGKARATLGQTDDAREDFQKVRKFSPEDKAVIRELRLLAEH 
               
               
                   
                   
                 DKQVYQKQKEMFKGLFGQKPEQKPKKLHWFVVFWQWLLSMIRTIFRMRSKTD 
               
               
                   
               
               
                 435 
                 Peptidylprolyl 
                 MAGAGEGTPEVTLETSMGPITVELYHKHAPKTCRNFLELSRRGYYNNVKFHRVI 
                 93 
                 584 
               
               
                   
                 isomerase 
                 KDFMVQGGDPTGTGRGGESIYGPRFEDEITRDLKHTGAGILSMANAGPNTNGSQ 
               
               
                   
                   
                 FFISLAPTPWLDEKHTIFGRVCKGMDVVKRLGNVQTDKNDRPIHDVKILRTTVKD 
               
               
                   
               
               
                 436 
                 Peptidylprolyl 
                 MMDPELMRLAQEQMSKISPDELMKMQRQIMANPDLMRMASENMKNLKPEDIRFA 
                 250 
                 1869 
               
               
                   
                 isomerase 
                 AEQMKNVRKEEMAEISERISRASPEEIEAMKARANLQSAYQLQVAQNLKDQGNQ 
               
               
                   
                   
                 LHARMKYSEAAEKYLQARNNLTGIPFSEAKSLLLASSSNLMSCYLKTGQYEECV 
               
               
                   
                   
                 QTGSEVLAYDAMNVKALYRRGQAYKQIGKLELAVADLRKAVEVSPEDETIAQAL 
               
               
                   
                   
                 REASTELMEKGGTQDQNGPRIEEIIEEEAVQPTAEKYPQSAPMVTSVTEDVSDD 
               
               
                   
                   
                 EQGSEDQNGFSRDSFQATNAPDGQMYAESLRNLTENPDMLRTMQSLMKNVDPDS 
               
               
                   
                   
                 LVALSGGKLSPDMVKTVSGMFGRMSPEEIQNMMKMSSTLSRQNPSTSSRFDDIT 
               
               
                   
                   
                 RGHSNMDSSPQSVSVDNDLFEENQNRVGESSTNLSSSAAFSGMPNFSAEMQEQV 
               
               
                   
                   
                 RNQMNDPATRQMFTSMIQNMSPEMMASMSEQFGVKLSPEDAVKAQNAMASLSPN 
               
               
                   
                   
                 DLDRLMNWATRLQTAIDYARKIKNWILGRPGLIFAISMLLLAIILHRFGYIGD 
               
               
                   
               
               
                 437 
                 Peptidylprolyl 
                 MGVEKEILRPGNGPKPRPGQSVTVHCTGYGKNEDLSQKFWSTKDPGQKPFTFTI 
                 84 
                 422 
               
               
                   
                 isomerase 
                 GQGRVIKGWDEGVLDMQLGEIFKLRCSPDYGYGSNGFPAWGIRPNSVLVFEIEV 
               
               
                   
                   
                 LSVN 
               
               
                   
               
               
                 438 
                 Peptidylprolyl 
                 MPNPRCYLDITIGEELEGRILVELYSDVVPKTAENFRALCTGEKGIGPHTGVPL 
                 128 
                 1213 
               
               
                   
                 isomerase 
                 HYKGLPFHRVIKGFMIQGGDISAQNGTGGESIYGLKFDDENFQLKHERRGMLSM 
               
               
                   
                   
                 ANSGPNTNGSQFFITTTRTSHLDGKHVVFGKVIKGMGVVRGIEHTPTESNDRPS 
               
               
                   
                   
                 LDVVISDCGEIPEGSDDGIANFFKDGDLYPDWPADLDEKSAEISWWMNAVDSAK 
               
               
                   
                   
                 CFGNENYKKGDYKMALRKYRKALRYLDICWEKEEIDEEKSNHLRKTKSQIFTNS 
               
               
                   
                   
                 SACKLKLGDLKGALLDTEFAMRDGEDNVKALFRQGQAYMALKDVDSAVASFKKA 
               
               
                   
                   
                 LQLEPNDAGIRKELAVATKMINDRRDQERRAYARMFQ 
               
               
                   
               
               
                 439 
                 Peptidylprolyl 
                 MGDVIDLNGDGGVLKTIIRSAKPGAMQPTEDLPNVDVHYEGTLADTGEVFDTTR 
                 265 
                 837 
               
               
                   
                 isomerase 
                 EDNTLFSFELGKGTVIKAWDIAVKTMKVGEVARITCKPEYAYGSAGSPPDIPEN 
               
               
                   
                   
                 ATLIFEVELVACKPRKGSTFGSVSDEKARLEELKKQREIAAASKEEEKKRREEA 
               
               
                   
                   
                 KATAAARVQAKLEAKKGQGRGKGKSKGK 
               
               
                   
               
               
                 440 
                 Peptidylprolyl 
                 MGLGLKIASASFLPIFNIMATRSLCILLVCFIPVLAHVLSLQDPELGTVRVYFQ 
                 38 
                 781 
               
               
                   
                 isomerase 
                 TTYGDIEFGFFPHVAPKTVEHIYKLVRLGCYNSNHFFRVDKGFVAQVADVVGGR 
               
               
                   
                   
                 EVPLNSEQRKEGEKTIVGEFSEVKHVRGILSMGRYSDPDSASSSFSILLGNAPH 
               
               
                   
                   
                 LDGQYAVFGKVTKGDDTLKRLEEVPTRQEGIFVMPLERIRILSTYYYDTNERES 
               
               
                   
                   
                 NLTCDHEVSILKRRLVESAYEIEYQRRKCLP 
               
               
                   
               
               
                 441 
                 Peptidylprolyl 
                 MASKRSLRTMNVWPTLPPLVLLLLLCFSSMSSSVVAKKSDVSELQIGVKHKPKS 
                 38 
                 526 
               
               
                   
                 isomerase 
                 CDIQAHKGDRIKVHYRGSLTDGTVFDSSFERGDPIEFELGSGQVIKGWDQGLLG 
               
               
                   
                   
                 MCVGEKRKLRIPSKLGYGAQGSPPKIPGGATLIFDTELVAVNGKGISNDGDSDL 
               
               
                   
               
               
                 442 
                 Peptidylprolyl 
                 MSGAPAERPISYFDITIGGKPIGRIVFSLYADLVPKTAENFRALCTGEKGIGKS 
                 37 
                 1158 
               
               
                   
                 isomerase 
                 GKPLCYAGSGFHRVIKGFMCQGGDFTAGNGTGGESIYGEKFEDEAFPVKHTKPF 
               
               
                   
                   
                 LLSMANAGKDTNGSQFFITVSQTPHLDDKHVVFGEVIKGKSIVRAIENYPTASG 
               
               
                   
                   
                 DVPTSPIIISACGVLSPDDPSLAASEETIGDSYEDYPEDDDSDVQNPEVALDIA 
               
               
                   
                   
                 RKIRELGNKLFKEGQIELALKKYLKSIRYLDVHPVLPDDSPPELKDSYDALLAP 
               
               
                   
                   
                 LLLNSALAALRTQPADAQTAVKNATRALERLELSDADKAKALYREASAHVILKQ 
               
               
                   
                   
                 EDEAEEDLVAASQLSPEDMAISSKLKEVKDEKKKKREKEKKAFKKMFSS 
               
               
                   
               
               
                 443 
                 Peptidylprolyl 
                 MASSLRSSLFSSWALDSKSVCSLFNLNPGKMGLPSISTPLNWRTCCCSHSSELL 
                 61 
                 768 
               
               
                   
                 isomerase 
                 ELNEGLQSSRRKTVMGLSTVIALSLVYCDEVGAVSTSKRALRSQKVPEDEYTTL 
               
               
                   
                   
                 PNGLKYYDLKVGSGTEAVKGSRVAVHYVAKWKGITFMTSRQGMGITGGTPYGFD 
               
               
                   
                   
                 VGASERGAVLKGLDLGVQGMRVGGQRILIVPPELAYGNTGIQEIPPNATLEFDV 
               
               
                   
                   
                 ELISIKQSPEGSSVKIVEG 
               
               
                   
               
               
                 444 
                 WD40 repeat 
                 MGAIEDEEPPLKRLKVSSPGLRRGLEEEAPSLSVGSVSILMAKSLSLEEGETVG 
                 421 
                 2172 
               
               
                   
                 protein 
                 SKGLIRRVEFVRIITQALYSLGYQKAGALLEEESGILLQSSNVALFRKQILDGK 
               
               
                   
                   
                 WDESVVTLRGIDQVEVEGNTLKAASFLILQQKFFELLDKGNIPEAMKTLRLEIS 
               
               
                   
                   
                 PMQLNTKRVHELASCIVFPSRCEELGYSKQGNPKSSQRMKVLQEIQQLLPPSIM 
               
               
                   
                   
                 IPEKRLERLVEQALNVQREACIFHNSLDPALSLYTDHQCGRDQIPTTTLQVLES 
               
               
                   
                   
                 HKNEVWFLQFSNNGKYLASASKDCSAIIWEITEGDSFSMKHRLSAHQKPVSFVA 
               
               
                   
                   
                 WSPDDKLLLTCGIEEVVKLWNVETGECKLTYDKANSGFTSCGWFPDGERFISGG 
               
               
                   
                   
                 VDKCIYIWDLEGKELDSWKGQGMPKISDLAVTSDGKEIISICGDNAIVMYNLDT 
               
               
                   
                   
                 KTERLIEEESGITSLCVSKDSRFLLLNLANQEIHLWDIGARSKLLLKYKGHRQG 
               
               
                   
                   
                 RYVIRSCFGGSDLAFVVSGSEDSQVYIWHRGNGELLAVLPGHSGTVNCVSWNPV 
               
               
                   
                   
                 NPHVFASASDDYTIRIWGVNRNTFRSKNASSSNGVVHLANGGP 
               
               
                   
               
               
                 445 
                 WD40 repeat 
                 MPGTTAGAGIEPIEPQSLKKLSLKSLKRSFDLFASLHGEPQPPDQRSQRIRIAC 
                 163 
                 1647 
               
               
                   
                 protein 
                 KVRAEYEVVKNLPTLPQREVGSSVSNSNVGETHSSLTTNQAQGFPTDTSGDLSK 
               
               
                   
                   
                 DEGKEITSIAVHLQPQTGLIDGKAGAIAGTSTAISSVGSSDRYQPSAAIMKRLP 
               
               
                   
                   
                 SKWPRPIWHPPWKNYRVISGHLGWVRSVAFDPGNEWFCTGSADRTIKIWEVATG 
               
               
                   
                   
                 KLKLTLTGHIEQIRGLAVSSRHPYLFSAGDDKQVKCWDLEYNKAIRSYHGHLSG 
               
               
                   
                   
                 VYCLALHPTLDILCTGGRDSVCRVWDIRTKAQIFALSGHENTVCSVFTQAIDPQ 
               
               
                   
                   
                 VVTGSHDTTIKLWDLAAGKTMSTLTYHKKSVRAIAKHPFEHTFASASADNIKKF 
               
               
                   
                   
                 KLPKGEFLHNMLSQQKTIVNAMAINEDNVLVSAGDNGSLWFWDWKSGHNFQQAQ 
               
               
                   
                   
                 TIVQPGSLDSEAGIYALQYDITGSRLVSCEADKTIKMWKEDETATPESHPINFK 
               
               
                   
                   
                 APKDIRRF 
               
               
                   
               
               
                 446 
                 WD40 repeat 
                 MRPILMKGHERPLTFLKYNRDGDLLFSCAKDHTPTVWYGHNGERLGTYRGHNGA 
                 192 
                 1172 
               
               
                   
                 protein 
                 VWCCDVSRDSTRLITSSADQTAKLWNVETGAQLFSFNFESPARAVDLAIGDKLV 
               
               
                   
                   
                 VITTDPFMELPSAIHIKRIEKDLSKQTADSVLTITGIKGRINRAVWGPLNSTII 
               
               
                   
                   
                 SGGEDSVVRIWDSETGKLLRESDKETGHQKPITSLCKSADGSHFLTGSLDKSAR 
               
               
                   
                   
                 LWDIRTLTLIKTYVTERPVNAVAISPLLDHVVIGGGQEASHVTTTDRRAGKFEA 
               
               
                   
                   
                 KFFHKILEEEIGGVKGHFGPINSLAFNPDGRSFASGGEDGYVRLHHFDPDYFHI 
               
               
                   
                   
                 KM 
               
               
                   
               
               
                 447 
                 WD40 repeat 
                 MRPILMKGHERPLTFLKYNRDGDLLFSCAKDHTPTVWYGHNGERLGTYRGHNGA 
                 131 
                 1111 
               
               
                   
                 protein 
                 VWCCDVSRDSTRLITSSADQTAKLWNVETGNQLFSFNFESPARAVDLAIGDKLV 
               
               
                   
                   
                 VITTDPFMELPSAIHIKRIEKDLSKQTADSVLTITGIKGRINRAVWGPLNSTII 
               
               
                   
                   
                 SGGEDSVVRIWDSETGKLLRESDKETGHQKAITSLCKSADGSHFLTGSLDKSAR 
               
               
                   
                   
                 LWDIRTLTLIKTYVTERPVNAVAISPLLDHVVIGGGQEASHVTTTDRRAGKFEA 
               
               
                   
                   
                 KFFHKILEEEIGGVKGHFGPINSLAFNPDGRSFASGGEDGYVRLHHFDPDYFHI 
               
               
                   
                   
                 KM 
               
               
                   
               
               
                 448 
                 WD40 repeat 
                 MAENNVGDFIPLDRQEYPSKPAPGAVDSSFWKSFKKKEVSRQIAGVTCINFCPE 
                 149 
                 1726 
               
               
                   
                 protein 
                 PPHDFAVTSSTRVHIYDGKSCELKKTITKFKDVAYSGVFRSDSQIIAAGGETGV 
               
               
                   
                   
                 IQVFNAKSQMVLRQLKGHGRPVRVVRYSPQDKLHLLSGGDDSMVKWWDITTQEE 
               
               
                   
                   
                 LLNLEGHKDYVRCGAASPSSVNLWATGSYDHTVRLWDLRNSKTVLQLKHGKPLE 
               
               
                   
                   
                 DVLFFPSGGLLATAGGNVVKVWDILGGGRPIHTMETHQKTVMAMCISKVPRSGQ 
               
               
                   
                   
                 ALGDAPSRLVTASLDGYMKVFDLDHFKVTHSARYPAPILSMGISSLCRTMAVGT 
               
               
                   
                   
                 SSGLLFIRQRKGQIEDKIHSDSSGLQVNPVNDEKDSAVLKPNQYRYYLRGRSEK 
               
               
                   
                   
                 PSEGDYVVKRMAKVYFQEYDKDLRHFNHSKALVSALKAADSKGTVAVIEELVAR 
               
               
                   
                   
                 KRLIQTLSILNLDELELLINFLSRFILVPKYSRFLISLTDRVLDARAVDLGKSE 
               
               
                   
                   
                 NLKKQIADLKGIVVQELRVQQSMQELQGIIEPLIRASAR 
               
               
                   
               
               
                 449 
                 WD40 repeat 
                 MDVETSGKPTGNKRTYTRLPRQVCVFWQEGRCTRESCNFLHVDEPGSVKRGGAT 
                 948 
                 2228 
               
               
                   
                 protein 
                 NGFAPKRSYNGSDERDTLAAGPPGGSRRNISARWGRGRGGIFISDERQKIRNKV 
               
               
                   
                   
                 CNYWLAGNCQRGEECKYLHSFVMGSDVKFLTQLSGHVKAIRGIAFPSDSGKLYS 
               
               
                   
                   
                 GGQDKKVIVWDCQTGQGTDIPLNDEVGCLMSEGPWIFVGLPNAVKAWNILTSTE 
               
               
                   
                   
                 LSLVGPRGQVHALAVGNGMLFAGTHDGSILAWKFSPASNTFEPAASLVGHTQAV 
               
               
                   
                   
                 VSLVSGADRLYSGSMDKTIRVWDLGTFQCLQTLRDHTSVVMSLLCWDQFLLSCS 
               
               
                   
                   
                 LDNTVKVWVATSSGALEVTYTHNEEHGVLALCGMNDEQAKPVLLCSCNDNTVRL 
               
               
                   
                   
                 YDLPSFSERGRIFSRNEVRTFQIAPGGLFFTGDATGELKVWNWATQKS 
               
               
                   
               
               
                 450 
                 WD40 repeat 
                 MSVQELRERHAAATAKVNALRERIKAKRLQLLDTDVATYASSNGRTPISFSFTD 
                 332 
                 1465 
               
               
                   
                 protein 
                 LVCCRTLQGHTGKVYSLDWTSEKNRIVSASQDGRLIVWNALTSQKTHAIKLPCA 
               
               
                   
                   
                 WVMTCAFSPSGQAVACGGLDSVCSIFQLNNQLDRDGHLPVSRILSGHRSYVSSC 
               
               
                   
                   
                 QYVPDGDTHVITGSGDRTCIQWDVTTGQRIAIFGGEFPLGHTADVMSVSISAAN 
               
               
                   
                   
                 PKEFVSGSCDTTTRLWDTRIASRAIRTFHGHEADVNTVKFFPDGLRFGSGSDDG 
               
               
                   
                   
                 TCRLFDIRTGHQLQVYRQPPRENQSPTVTAIAFSFSGRLLFAGYSNGDCFVWDT 
               
               
                   
                   
                 ILEKVVLNLGELQNTHNGRISCLGLSADGSALCTGSWDKNLKIWAFGGHRKIV 
               
               
                   
               
               
                 451 
                 WD40 repeat 
                 MKVKIISRSTDEFTRERSNDLQRVFRNFDPNLHTQARAQEYVRALNAAKLDKIF 
                 232 
                 1590 
               
               
                   
                 protein 
                 AKPFLAAMSGHIDGISAMAKSPRHLKSIFSGSVDGDIRLWDIAARRTVQQFPGH 
               
               
                   
                   
                 RGAVRGLTVSTEGGRLISCGDDCTVRLWDIPVAGIGESSYGSENVQKPLATYVG 
               
               
                   
                   
                 KNSFRAVDYQWDSNVFATGGAQVDIWDHDRSEPTNSFAWGSDTVISVRFNPAEK 
               
               
                   
                   
                 DIFATTASDRSIVLYDLRMASPLNKLIMQTRNNAIAWNPREPMNFTAANEDCNC 
               
               
                   
                   
                 YSYDMRRMNISTCVHQDHVSAVMDIDYSPSGREFVTGSYDRTVRIFPYNAGHSR 
               
               
                   
                   
                 EIYHTKRMQRVFCVKFSGDATYVVSGSDDANIRLWKAKASEQLGVLLPRERKRH 
               
               
                   
                   
                 EYLDAVKERFKHLPEIKRIERHRHLPKPIYKAALLRHTVNAAAKRKEERKRAHS 
               
               
                   
                   
                 APGSVVTNPLRKKRIVAQLE 
               
               
                   
               
               
                 452 
                 WD40 repeat 
                 MDHYYQDDFDYLVDDEMVDFADDVEDDVRTRRRSDIDSDSENDFDLNNKSPDTT 
                 207 
                 1550 
               
               
                   
                 protein 
                 ALQAKRGKDIQGIPWNRLNFTREKYRETRLQQYKNYENLPRPRRSRNLDKECTN 
               
               
                   
                   
                 FERGSSFYDFRHNTRSVKATIVHFQLRNLVWATSKHNVYLMQNYSIMHWSSLKQ 
               
               
                   
                   
                 KGEEVLNVAGPIVPSVKHPGSSPQGLTRVQVSAMSVKDNLVVAGGFQGELICKY 
               
               
                   
                   
                 LDKPGVSFCTKISHDENGITNAVEIYNDASGATRLMTANNDLAVRVFDTEKFTV 
               
               
                   
                   
                 LERFSFPWSVNHTSVSPDGKLVAVLGDNADCLLADCKTGKTVGTLRGHLDYSFA 
               
               
                   
                   
                 AAWHPDGYILATGNQDTTCRLWDVRKLSSSLAVLKGRMGAIRSIRFSSDGRFMA 
               
               
                   
                   
                 MAEPADFVHLYDTRQNYTKSQEIDLFGEIAGISFSPDTEAFFVGVADRTYGSLL 
               
               
                   
                   
                 EFNRRRMNYYLDSIL 
               
               
                   
               
               
                 453 
                 WD40 repeat 
                 MAEALVLRGTMEGHTDAVTAIATPIDNSDMIVSSSRDKSILLWNLTKEPEKYGV 
                 221 
                 1171 
               
               
                   
                 protein 
                 PRRRLTGHSHFVQDVVISSDGQFALSGSWDSELRLWDLNTGLTTRRFVGHTKDV 
               
               
                   
                   
                 LSVAFSIDNRQIVSASRDRTIKLWNTLGECKYTIQPDAEGHSNWISCVRFSPSA 
               
               
                   
                   
                 TNPTIVSCSWDRTVKVWNLTNCKLRNTLVGHGGYVNTAAVSPDGSLCASGGKDG 
               
               
                   
                   
                 VTMLWDLAEGKRLYSLDAGDIIYALCFSPNRYWLCAATQQCVKIWDLESKSIVA 
               
               
                   
                   
                 DLRPDFIPNKKAQIPYCTSLSWSADGSTLFSGYTDGKIRVWGIGHV 
               
               
                   
               
               
                 454 
                 WD40 repeat 
                 MAAIKSTSRSASVAFAPDAPLLAAGTMAGAIDLSFSSLANLEIFKLDFQSDDPE 
                 221 
                 3679 
               
               
                   
                 protein 
                 LPVVGECPSNERLNRLSWGSAGGSFGIIAGGLVDGTINIWNPATLINSEDNGDA 
               
               
                   
                   
                 LIARLEQHTGPVRGLEFNTISTNLLASGAEDGELCIWDLANPTAPTHFPPLKGV 
               
               
                   
                   
                 GSGAQGEISFLAWNRKVQHILASTSYSGTTVVWDLRRQKPIISFPDATRRRCSV 
               
               
                   
                   
                 LQWNPDASTQLIVASDDDNSPTLRAWDLRNTISPYKEFVGHSRGVIAMSWCPSD 
               
               
                   
                   
                 SLFLLTCAKDNRTLCWDTGSGEIVCELPAGANWNFDVQWSPKIPGILSTSSFDG 
               
               
                   
                   
                 KIGIHNIEACSRNVSGEVEFGGAIVRGGPSALLKAPKWLERPAGVSFGFGGKLA 
               
               
                   
                   
                 SFRPSTVAQAADHRHSEVFIHNLVTEDNLVIRSTEFEAAIADGEKVSLRALCDR 
               
               
                   
                   
                 KAEESQSDEEKETWNFLRVMFEDEGTARTKLLEHLGFKVQSEENGDLQETHSSK 
               
               
                   
                   
                 IDDIGSEIGKTLTLDDKTEEDVLPQLKGGQDAAIPQDNGEDFFDNLHSPKEEVS 
               
               
                   
                   
                 LSHVGNDFVGEKDKDMVVNGAEIEHETEDLTEYSDWNEAIQHSLVVGDYKGAVL 
               
               
                   
                   
                 QCLSANRMADALIIAHLGGNSLWEKTRDEYLKKAKSSYLKVVSAMVNNDLTGLV 
               
               
                   
                   
                 NSRPLKSWKETLAMLCTYSQREEWTVLCDMLASRLIAAGNVMAATLCYICAGNI 
               
               
                   
                   
                 EKTVEIWSRSLKYDYDGRSFVDHLQDVMEKTVVLALATGQKRVSPSLSKLVENY 
               
               
                   
                   
                 AELLASQGLLTTAMEYLKLLGTEESSHELSILRDRLYLSGTDNKVEASSFPFET 
               
               
                   
                   
                 RQDLTESQYNMHQTGFGAPETQKNYQENVHQVLPSGSYTDNYQPTANTHYIAGY 
               
               
                   
                   
                 QPAPQQQPSFQNYFTPASYQPAPSPNVFYPSQVSQAEQSNFAPPVNQPPMKTFV 
               
               
                   
                   
                 PSTPPILRNVDQYQTPSLNPQLYQGVSSATVETHPYQTGAPASVSVGTTPGQPS 
               
               
                   
                   
                 VVPNFMVPGPVTAPTVTPRGFMPVTTPTQHPLGSANPPVQPQSPQSSQVQSVTA 
               
               
                   
                   
                 ATTPPPTIQNVDTSNVAAEIRPVIGTLRRLYDETSEALGGARANPAKRREIEDN 
               
               
                   
                   
                 SRKIGSLFAKLNSGDISSNAASKLVHLCQALESRDYATAFQIQVGLTTSDWDEC 
               
               
                   
                   
                 SFWLAALKRMIKVKQNMR 
               
               
                   
               
               
                 455 
                 WD40 repeat 
                 MAGAADSQLQTLSERDSTPNFKNLHTREYAAHKKKVHSVAWNCTGTKLASGSVD 
                 269 
                 1252 
               
               
                   
                 protein 
                 QTARVWNIEPHGHSKTKDLELKGHADSVDQLCWDPKHSELLATASGDRTVRLWD 
               
               
                   
                   
                 ARSGKCSQQVELSGENINITFKPDGTHIAVGNRDDELTIIDVRKFKPLHKRKFS 
               
               
                   
                   
                 YEVNEIAWNTTGELFFLTTGNGTVEVLSYPSLQVLHTLVAHTAGCYCIAIDPIG 
               
               
                   
                   
                 RYFAVGSADALVSLWDLSEMLCVRTFTKLEWPVRTISFNHDGQYIASASEDLFI 
               
               
                   
                   
                 DIADVQTGRTVHQISCRAAMNSVEWNPKYNLLAFAGDDKNKYMQDEGVFRVFGF 
               
               
                   
                   
                 ETP 
               
               
                   
               
               
                 456 
                 WD40 repeat 
                 MAATSPVGAGSGRELANPPTDGISNLRFSNHSDHLLVSSWDRKVRLYDASANSL 
                 214 
                 1242 
               
               
                   
                 protein 
                 KGQFVHGGPVLDCCFHDDASGFSGSADNTVRRYDFSTRKEDILGRHEAPVRCVE 
               
               
                   
                   
                 YSYAAGQVITGSWDKTLKCWDPRGASGQEKTLVGTYSQLERVYSMSLVGHRLVV 
               
               
                   
                   
                 ATAGRHINVYDLRNMSQPEQRRESSLKYQTRCVRCYPNGTGFALSSVEGRVAME 
               
               
                   
                   
                 FFDLSEAGQAKKYAFKCHRKSEAGRDTVYPVNAIAFHPIYGTFATGGCDGYVNV 
               
               
                   
                   
                 WDGNNKKRLYQYSKYPTSIAALSFSRDGRLLAVASSYTFEEGEKPHEPDAVFVR 
               
               
                   
                   
                 SVNEAEVKPKPKVYAAPP 
               
               
                   
               
               
                 457 
                 WD40 repeat 
                 MASDDEEGFKNEEAPGVVDEAEVQEGLRACFPLSFGKQEKKQAPLESIHSATKR 
                 119 
                 2065 
               
               
                   
                 protein 
                 PEDPRPRRQLGPPRPPPSILAEQEDSDRFVGPPRPPQFVRDDNDDGEAEIMIGP 
               
               
                   
                   
                 PRPPAQYSDDHDNEETIGPPKPSYLEKGEETDQMVGPSKRGSDDETSGDSDDGD 
               
               
                   
                   
                 DAVDFRVPLSNEIVLRGHTKVVSALAIDQTGSRVLTGSYDYSVRMYDFQGMTSQ 
               
               
                   
                   
                 LKSFRQLEPAEGHQVRSLSWSPTSDRFLCVTGSAQAKIFDRDGLTLGEFVKGDM 
               
               
                   
                   
                 YLRDLKNTKGHISGLTCGEWHPKEKQTILTCSEDGSLRIWDVNDFNTQKQVIKP 
               
               
                   
                   
                 KLAKPGRVPVTACAWGRDGKCIAGGVGDGSIQVWNLKPGWGSRPDLYVAKGHDD 
               
               
                   
                   
                 DITGLQFSADGNILLTRSTDETLKVWDLRKAITPLQVFRDLPNNYAQTNVAFSP 
               
               
                   
                   
                 DERLIFTGTSVERDGNSGGLLCFYDRQTLELVLRIGVSPVHSVVRCTWHPRHNQ 
               
               
                   
                   
                 VFATVGDKKEGGAHILYDPALSERGALVCVARAPRKKSLDDFEAKPVIHNPHAL 
               
               
                   
                   
                 PLFRDEPSRKRQREKARMDPMKSQRPDLPVTGPGFGGRVGSTKGSLLTQYLLKE 
               
               
                   
                   
                 GGLIKETWMEEDPREAILKYADVAAKDPKFIAPAYAQTQPETVFAETDSEEEQK 
               
               
                   
               
               
                 458 
                 WD40 repeat 
                 MKERGQSHAGQPSVDERYTQWKSLVPVLYDWLANHNLVWPSLSCRWGPQMHQAT 
                 186 
                 1550 
               
               
                   
                 protein 
                 YKNSQRLYLSEQTDGTVPNTLVIATCEVVKPRVAAAEHISQFNEEARSPFVKKF 
               
               
                   
                   
                 KTIIHPGEVNRIRELPQNSKIVATHTDGPDVLIWDVDTQPNRQATLGAADSRPD 
               
               
                   
                   
                 LVLTGHKDNAEFALAMSPSAPFVLSGGKDKCVLLWSIQDHISAATEPSSAKASK 
               
               
                   
                   
                 TPSSAHGEKVPKIPSIGPRGVYKGHKDTVEDVQFCPSNAQEFCSVGDDSALILW 
               
               
                   
                   
                 DARNGNEPVIKVEKAHNADLHCVDWNPHDENLILTGSADNSVRMFDRRNLTSSG 
               
               
                   
                   
                 VGSPVHKFEGHSAPVLCVQWCPDKASVFGSAAEDSYLNVWDYEKVGKNVGKKTP 
               
               
                   
                   
                 PGLFFQHAGHRDKVVDFHWNSFDPWTIVSVSDDGESTGGGGTLQIWRMSDLIYR 
               
               
                   
                   
                 PEDEVLAELERFRAHILSCQNK 
               
               
                   
               
               
                 459 
                 WD40 repeat 
                 MSSLSRELVFLILQFLDEEKFKESVHKLEQESGFFFNMKYFDEKAQAGEWDEVE 
                 244 
                 3671 
               
               
                   
                 protein 
                 RYLSGFTKVDDNRYSMKIFFEIRKQKYLEALDRQDRAKAVDILVKDLKVFSTFN 
               
               
                   
                   
                 EELYKEITQLLTLDNFRENEQLSKYGDTKSARTIMMSELKKLIEANPLFREKLI 
               
               
                   
                   
                 YPNLKASRLRTLINQSLNWQHQLCKNPRPNPDIKTLFTDHACGPPNGARTPTQP 
               
               
                   
                   
                 TASLGVLPKATTFTPIGPHGPFPSSSTATSGLASWMSNPNMVTSPQAPVAVGPS 
               
               
                   
                   
                 VPVPPNQATLLKRPRTPPGSSSVVDYQTADSEQLIKRLRPVSQSIDEATYPGPT 
               
               
                   
                   
                 LRVPWSTDDLPKTLARALNEPYPVTSIDFHPSQQTFLLVGTKNGEITLWEVGSR 
               
               
                   
                   
                 EKLATRSFKIWDNANCSNHLEAAFVKDSSVSINRVLWSPDGTLIGIAFTKHLVH 
               
               
                   
                   
                 TYTFQGLDLRQHLEIDAHVGGVNDLAFSHPNKQLCVVTCGDDKMIKVWDAVTGR 
               
               
                   
                   
                 KLYNFEGHDAPVYSVCPHHKENIQFIFSTAVDGKIKAWLYDHLGSRVDYDAPGH 
               
               
                   
                   
                 SCTTMMYSADGTRLFSCGTSKEGESFLVEWNESEGAIKRTYSGLRKKGSGVVQF 
               
               
                   
                   
                 DTTQNHFLAVGDEHLIKFWDMDSTNMLTSCDAEGGLLNLPRLRFNKEGSLLAVT 
               
               
                   
                   
                 TVNGIKILANADGQKLLKTMENRTFDLPSRAHIDAASATSSPATGRMERIERTS 
               
               
                   
                   
                 SANTVSGINGVDPAQSSEKLRLSDDLSEKTKIWKLTEITDSIQCRCITLPENAA 
               
               
                   
                   
                 EPASKVSRLLYTNSGVGLLALGSNAVHKLWKWNRSEQNPSGKATASVHPQRWQP 
               
               
                   
                   
                 TSGLLMTNDITDINPEEAVPCIALSKNDSYVMSASGGKVSLFNMMTFKVMTTFM 
               
               
                   
                   
                 PPPPASTFLAFHPQDNNIIAIGMEDSTIHIYNVRVDEVKTKLKGHQKRITGLAF 
               
               
                   
                   
                 SSTQNILVSSGADAQLCVWNTETWEKRKSKTIQMPVGKTVSGDTRVQFHSDQLH 
               
               
                   
                   
                 ILVVHETQLAIYDAYKLERQYQWVPQDALSAPILYATYSCNRQLIYATFSDGNI 
               
               
                   
                   
                 GVYDAEILRPRCRIAPTTYLSSGTSSSTSLPLVVAAHPHEPNQFAIGLSDGAVQ 
               
               
                   
                   
                 VLEPSESEGKWGVSPPPENGVVPAVVAGPSTSNQGSEQAPR 
               
               
                   
               
               
                 460 
                 WD40 repeat 
                 MAKDEEEFRGEMEERLVNEEYKIWKKNTPFLYDLVITHALEWPSLTVQWLPDRE 
                 163 
                 1431 
               
               
                   
                 protein 
                 EPPGKDYSVQKMILGTHTSDNEPNYLMLAQVQLPLEDAENDARQYDDERGEIGG 
               
               
                   
                   
                 FGCANGKVQVIQQINHDGEVNRARYMPQNPFIIATKTVSAEVYVFDYSKHPSKP 
               
               
                   
                   
                 PQDGGCHPDLRLRGHNTEGYGLSWSPFKHGHLLSGSDDAQICLWDINVPAKNKV 
               
               
                   
                   
                 LEAQQIFKVHEGVVEDVAWHLRHEYLFGSVGDDRHLLIWDLRTSATNKPLHSVV 
               
               
                   
                   
                 AHQGEVNCLAFNPFNEWVLATGSADRTVKLFDLRKISSALHTFSCHKEEVFQIG 
               
               
                   
                   
                 WSPKNETILASCSADRRLMVWDLSRIDEFQTPEDALDGPPELLFIHGGHTSKIS 
               
               
                   
                   
                 DFSWNPCEDWVIASVAEDNILQIWQMAENIYHDEEDDMPPEEVV 
               
               
                   
               
               
                 461 
                 WD40 repeat 
                 MSPGVKQTGSQKFESGHQDVVHDVTMDYYGKRIATCSADRTIKLFGLNASDTPS 
                 155 
                 1081 
               
               
                   
                 protein 
                 LLASLTGHEGPVWQVAWAHPKFGSMLASCSYDGRVIIWREGQQENEWSQVQVFK 
               
               
                   
                   
                 EHEASVNSISWAPNELGLCLACGSSDGSITVFTCREDGSWDKTKIDQAHQVGVT 
               
               
                   
                   
                 AVSWAPASAPGSLVGQPSDPIQKLVSGGCDNTAKVWKFYNGSWKLDCFPPLQMH 
               
               
                   
                   
                 TDWVRDVAWAPNLGLPKSTIASCSQDGKVVIWTQGKEGDKWEGRILNDFKIPVW 
               
               
                   
                   
                 RVNWSLTGNILAVADGNNSVTLWKEAVDGDWNQVTTVQ 
               
               
                   
               
               
                 462 
                 WD40 repeat 
                 MSSGVKQTGSQKFESGHQDVVHDVTMDYYGKRIATCSADRTIKLFGMNTSDTPT 
                 537 
                 1463 
               
               
                   
                 protein 
                 LLASLTGHEGPVWQVAWAHPKFGSMLASCSYDRRVIIWREGQQENEWSQVQVFK 
               
               
                   
                   
                 EHEASVNSISWAPHELGLCLACGSSDGSITVFTGREDGSWDKTKIDQAHQVGVT 
               
               
                   
                   
                 AVSWAPASAPGSLVGQPSDPVQKLVSGGCDNTAKVWKFYNGSWKLDCFPPLQMH 
               
               
                   
                   
                 TDWVRDVAWAPNLGLPKSTIASCSQDGRVVIWTQGKEGDKWEGKILNDFKTPVW 
               
               
                   
                   
                 RISWSLTGNILAVADGNNNVTLWKEAVDGEWNQVTTVQ 
               
               
                   
               
               
                 463 
                 WD40 repeat 
                 MKKRSRPSNGHLSTAAKNKSRKTAPITKDPFFDSAHNRNKSKGKGKSRGKGEEI 
                 284 
                 1909 
               
               
                   
                 protein 
                 FSSDEDDDAIGRDAPAEEEEEIAEEERETADEKRLRVAKAYLDKIRAITKANEE 
               
               
                   
                   
                 DNEEEAGEDEETEAERRGKRDSLVAEILQQEQLEESGRVQRQLASRVVTPSKLV 
               
               
                   
                   
                 ECRVVKRHKQSVTAVALTEDDLRGFSASKDGTIIHWDVETGASEKYEWPSQAVS 
               
               
                   
                   
                 VSSSNEVSKTQKGKGSKKQGSKHVLSMAVSSDGRYLATGGLDRYIHLWDTRTQK 
               
               
                   
                   
                 HIQAFRGHRGAVSCLAFRQGTQQLISGSFDRTIKLWSAEDRAYMDTLYGHQSEI 
               
               
                   
                   
                 LAVDCLRKERVLSVGRDHTLRLWKVPEETQLVFRGHAASLECCCFINNEDFLSG 
               
               
                   
                   
                 SDDGSIELWSMLRKKPVFMAKNAHGHAIVENLSEDTSTREEPDEEVTTRQLPNG 
               
               
                   
                   
                 NSIGNGMTNQMGITPSVESWVGAVTVCRGTDLAASGAGNGVVRLWAIENSSKSL 
               
               
                   
                   
                 RALHDIPLTGFVNSLTFARSGRFLIAGVGQEPRLGRWGRIQAARNGVTLCPIELS 
               
               
                   
               
               
                 464 
                 WD40 repeat 
                 MAATFGTINTATSPHNPNKSFEIVQPPNDSISSLSFSPKANYLVATSWDNQVRC 
                 610 
                 1659 
               
               
                   
                 protein 
                 WEVLQTGASMPKAAMSHDQPVLCSTWKDDGTAVFSAGCDKQAKMWPLLTGGQPV 
               
               
                   
                   
                 TVAMHDAPIKDIAWIPEMNLLATGSWDKTLKYWDTRQSNPVHTQQLPERCFALS 
               
               
                   
                   
                 VRHPLMVVGTADRNLIIFNLQNPQTEFKRISSPLKYQTRCVAAFPDKQGFLVGS 
               
               
                   
                   
                 IEGRVGVHHVEEAQQSKNFTFKCHRDSNDIYAVNSLNFHPVHQTFATAGSDGAF 
               
               
                   
                   
                 NFWDKDSKQRLKAMARSNQPTPCSTFNSDGSLYAYAVSYDWSKGAENHNPATAK 
               
               
                   
                   
                 HHILLHVPQESEIKGKPRVTTSGRK 
               
               
                   
               
               
                 465 
                 WD40 repeat 
                 MVVMDKGTHQTNEDESESEFIDEDDVIDEISIDEEDLPDADVEGEDVQEDNKRS 
                 241 
                 1452 
               
               
                   
                 protein 
                 EPDENSSSLDDAIHTFEGHEDTLFAVACSPVDATWVASGGGDDKAFMWRIGHAT 
               
               
                   
                   
                 PFFELKGHTDSVVALSFSNDGLLLASGGLDGVVRIWDASTGNLIHVLDGPGGGI 
               
               
                   
                   
                 EWVRWHPKGHLVLAGSEDYSTWMWNADLGKCLSVYTGHCESVTCGDFTPDGKAI 
               
               
                   
                   
                 CTGSADGSLRVWNPQTQESKLTVKGYPYHTEGLTCLSISSDSTLVVSGSTDGSV 
               
               
                   
                   
                 HVVNIKNGKVVASLVGHSGSIECVRFSPSLTWVATGGMDKKLMIWELQSSSLRC 
               
               
                   
                   
                 TCQHEEGVMRLSWSLSSQHIITSSLDGIVRLWDSRSGVCERVFEGHNDSIQDMV 
               
               
                   
                   
                 VTVDQRFILTGSDDTTAKVFEIGAF 
               
               
                   
               
               
                 466 
                 WD40 repeat 
                 MPVFRTAFNGYAVKFSPFVETRLAVATAQNFGIIGNGRQHVLELTPNGIVEVCA 
                 223 
                 1173 
               
               
                   
                 protein 
                 FDSSDGLYDCTWSEANENLVVSASGDGSVKIWDIALPPVANPIRSLEEHAREVY 
               
               
                   
                   
                 SVDWNLVRKDCFLSASWDDTIRLWTIDRPQSMRLFKEHTYCIYAAVWNPRHADV 
               
               
                   
                   
                 FASASGDCTVRIWDVREPNATIIIPAHEHEILSCDWNKYNDCMLVTGSVDKLIK 
               
               
                   
                   
                 VWDIRTYRTPMTVLEGHTYAIRRVKFSPHQESLIASCSYDMTTCMWDYRAPEDA 
               
               
                   
                   
                 LLARYDHHTEFAVGIDISVLVEGLLASTGWDETVYVWQHGMDPRAC 
               
               
                   
               
               
                 467 
                 WD40 repeat 
                 MDSRNRRSRLNLPPGMSPSSLHLETTAGSPGLSRVNSSPSTPSPSRTTTYSDRF 
                 251 
                 1777 
               
               
                   
                 protein 
                 IPSRTGSRLNGFALIDKQPQPLPSPTRSAAEGRDDASSSSASAYSTLLRNELFG 
               
               
                   
                   
                 EDVVGPATPATPEKSTGLYGGSRDSIKSPMSPSRNLFRFKNDHGGNSPGSPYSA 
               
               
                   
                   
                 STVGSEGLFSSNVGTPPKPARKITRSPYKVLDAPALQDDFYLNLVDWSSNNVLA 
               
               
                   
                   
                 VGLGTCVYLWSACTSKVTKLCDLGVNDSVCSVGWTPQGTHLAVGTNIGEVQIWD 
               
               
                   
                   
                 TSRCKKVRTMGGHCTRAGALAWSSYILSSGSRDRNILHRDIRVQDDFIRKLVGH 
               
               
                   
                   
                 KSEVCGLKWSYDDRELASGGNDNQLLVWNQQSAQPLLRFNEHTAAVKAIAWSPH 
               
               
                   
                   
                 QHGILASGGGTADRCLRFWNTATDTRLNCVDTGSQVCNLVWCKNVNELVSTHGY 
               
               
                   
                   
                 SQNQIMVWRYPSMSKLATLTGHTLRVLYLAISPDGQTIVTGAGDETLRFWSIFP 
               
               
                   
                   
                 SPKSQSAVHDSGLWSLGRTHIR 
               
               
                   
               
               
                 468 
                 WD40 repeat 
                 MEKKKVVVPIVCHGHSRPIVDLFYSPVTPDGLFLISASKDSSTMLRNGETGDWI 
                 367 
                 1419 
               
               
                   
                 protein 
                 GTFEGHKGAVWSCCLDNRALRAASGSADFSAKIWDALTGDELHCFVHKHIVRAC 
               
               
                   
                   
                 AFSESTSLLLTGGHEKILRIFDLNRPDAPPKEVDNSPGSIRTVAWLHSDQTILS 
               
               
                   
                   
                 SNSDAGGVRLWDLRTEKIVRVLETKSPVTSAEVSQDGRYITTADGNSVKFWDAN 
               
               
                   
                   
                 HFGMVKSYTMPCMVESASLEPTMGNMFVAGGEDMWVRLFDFHTGEEIACNKGHH 
               
               
                   
                   
                 GPVHCVRFAPGGESYSSGSEDGTIRIWQTLNMNSEENESYGVNGLSGKVRVGVD 
               
               
                   
                   
                 DVVQKVEGFQITADGHLNDKPEKPNP 
               
               
                   
               
               
                 469 
                 WD40 repeat 
                 MERYSQGTQKKSEIYTYEAPWQIYGMNWSVRKDKKFRLGIGSFLEEYNNRVEII 
                 284 
                 1303 
               
               
                   
                 protein 
                 ELDEESGEFKSDPRLAFDHPYPTTKIMFVPDKECQRPDLLATTGDYLRIWQVCE 
               
               
                   
                   
                 DRVEPKSLLNNNKNSEFCAPLTSFDWNDADPKRIGTSSIDTTCTIWDIEKEVVD 
               
               
                   
                   
                 TQLIAHDKEVYDIAWGEVGVFASVSADGSVRVFDLRDKEHSTIIYESSQPETPL 
               
               
                   
                   
                 LRLGWNKQDPRFIATILMDSCKVVILDIRFPTLPVAELQRHQASVNTIAWAPHS 
               
               
                   
                   
                 PCHICTAGDDSQALIWELSSVSQPLVEGGGLDPILAYTAAAEINQLQWSSMQPD 
               
               
                   
                   
                 WVAIAFSNEVQILRV 
               
               
                   
               
               
                 470 
                 WD40 repeat 
                 MQSENNLDESLHLREVQELQGHTDTVWAVAWNPVTGIDGAPSMLASCSGDKTVR 
                 684 
                 1784 
               
               
                   
                 protein 
                 IWENTHTLNSTSPSWACKAVLEETHTRTVRSCAWSPNGKLLATASFDATTAIWE 
               
               
                   
                   
                 NVGGEFECIASLEGHENEVKSVSWSASGMLLATCGRDKSVWIWDVQPGNEFECV 
               
               
                   
                   
                 SVLQGHTQDVKMVQWHPNRDILVSASYDNSIKVWAEDGDGDDWACMQTLGNSVS 
               
               
                   
                   
                 GHTSTVWAVSFNSSGDRMVSCSDDLTLMVWDTSINPAERSGNAGPWKHLCTISG 
               
               
                   
                   
                 YHDRTIFSVHWSRSGLIASGASDDCIRLFSESTDDSVTPVDGTSYKLILKKEKA 
               
               
                   
                   
                 HSMDVNSVQWHPSEPQLLASASDDGRIKIWEVTRINGLANSH 
               
               
                   
               
               
                 471 
                 WD40 repeat 
                 MKRAYKLQEFVAHASNVNCLKIGKKSSRVLVTGGEDHKVNMWAIGKPNAILSLS 
                 336 
                 2738 
               
               
                   
                 protein 
                 GHSSAVESVTFDSAEALVVAGAASGTIKLWDLEEAKIVRTLTGHRSNCISVDFH 
               
               
                   
                   
                 PFGEFFASGSLDTNLKIWDIRRKGCIHTYKGHTRGVNSIRFSPDGRWVVSGGED 
               
               
                   
                   
                 NIVKLWDLTAGKLMHDFKCHEGQIQCMDFHPQEFLLATGSADRTVKFWDLETFE 
               
               
                   
                   
                 LIGSAGPETTGVRAMIFNPDGRTLLTGLHESLKVFSWEPLRCYDAVDVGWSKLA 
               
               
                   
                   
                 DLNIHEGKLLGCSYNQSCVGVWVVDISRVGPYAAGNVSRTNGHNEAKLASSGHP 
               
               
                   
                   
                 SVQQLDNNLKTNMARLSLSHSTESGIKEPKTTTSLTTTEGLSSTPQRAGIAFSS 
               
               
                   
                   
                 KNLPASSGPPSYVSTPKKNSTSRVQPTTNFQTLSRPDIVPVIVPRSNSLRPETT 
               
               
                   
                   
                 SDVKKEMNNFGRVVPSTVSTKSTDVIKSGSNRDESDKIDSINQKRMTGNDKTDL 
               
               
                   
                   
                 NIARAEQHVSSRLDNTNTSSVVCDGNQPAARWIGAAKFRRNSPVDPVVSPHDRS 
               
               
                   
                   
                 PTFPWSATDDGVTCQPDRQVTAPELSKRVVEPGRARALVASWETREKALTADTP 
               
               
                   
                   
                 VLVSGRPPTSPGVDMNSFIPRGSHGTSESDLTVSDDNSAIEELMQQHNAFTSIL 
               
               
                   
                   
                 QARLTKLQVIRRFWQRNDLKGAIDATGKMGDHSVSADVISVLIERSEIFTLDIC 
               
               
                   
                   
                 TVILPLLTRLLQSETDRHLTVAMETLLVLVKTFGDVIRATISATPTIGVDLQAE 
               
               
                   
                   
                 QRLERCNLCYVELENIKQILVPLIRRGGAVAKSAQELSLALQEV 
               
               
                   
               
               
                 472 
                 WD40 repeat 
                 MSTLEIEARDVIKIVLQFCKENSLHQTFQTLQNECQVSLNTVDSLETFVADINS 
                 81 
                 1622 
               
               
                   
                 protein 
                 GRWDVILPQVAQLKLPRKKLEDLYEQIVLEMIELRELDTARAILRQTQAMGFMK 
               
               
                   
                   
                 QEQPERYLRLEHLLVRTYFDPREAYHESSKEKRRSQIAQALASEVTVVPPSRLM 
               
               
                   
                   
                 ALIGQSLKWQQHQGLLPPGTQFDLFRGTAAVKADEEEMYPTTLAHTIKFGKQSH 
               
               
                   
                   
                 PECARFSPDGQYLVSCSVDGFIEVWDYISGKLKKDLQYQADDSFMMHDDAVLCV 
               
               
                   
                   
                 DFSRDSEMLASGSQDGKIKVWRIRTGQCLRRLERAHSQGVTSLSFSRDGSQLLS 
               
               
                   
                   
                 TSFDSTARIHGLKSGKALKEFRGHTSYVNDAIFTSDGGRVITASSDCTVKVWDV 
               
               
                   
                   
                 KTTDCIQTFKPPPPLKGGDVSVNSVHLFPKNSEHIVVCNKASSIYIMTLQGQVV 
               
               
                   
                   
                 KSFSSGKREGGDFVAACISPKGEWIYCVGEDRNIYCFSQQSGKLEHLMKAHDKD 
               
               
                   
                   
                 IIGVTPHPHRNLLVTYSEDSTMKIWKP 
               
               
                   
               
               
                 473 
                 WD40 repeat 
                 MDIELEDQPFDLDFHPSAPIVAVALITGRLQLFRYVDISSEPERLWTVTAHTES 
                 399 
                 1460 
               
               
                   
                 protein 
                 CRAARFINAGSSVLTASPDCSILATNVETGQPVARLDNAHGAAINCLTNLTEST 
               
               
                   
                   
                 IASGDENGIIKVWDTRQNSCCNKFKAHEDYISDMEFVPDTMQLLGTSGDGTLSV 
               
               
                   
                   
                 CNLRKNKVHARSEFSEDELLSVALMKNGKKVVCGSQEGVLLLYSWGYFKDCSDR 
               
               
                   
                   
                 FVGHPHSVDALLKLDEDTVLTGSSDGIIRVVSILPNKMIGVIGEHSSYPIERLA 
               
               
                   
                   
                 FSHDRNVLGSASHDQILKLWDIHYLHEDDEPETNKQEAVNDENVDMDLDVDTEK 
               
               
                   
                   
                 RPRGSKRKKRAEKGQTSSQKQSSDFFADI 
               
               
                   
               
               
                 474 
                 WD40 repeat 
                 MDRIQQIPHTCVARKINLPLGMSKESLALNLPANLAPTMSPPSITYSDRFIPSR 
                 207 
                 1673 
               
               
                   
                 protein 
                 KASNFEEFALPDKTSPSPNSAGGQSSSTNGEGRDDACAAYSALLRTELFPATPD 
               
               
                   
                   
                 KTEGCRRPVIGSPSGNVFRFKSQQCKSQSPFSLCPVGEDGDLSETGAVARKTTR 
               
               
                   
                   
                 KIPRSPFKVLDAPALQDDFYLNLVDWSSHNILAVGLSACVYLWSASSSKVTKLC 
               
               
                   
                   
                 DLGLDDNVCSVAWTQRGTYLAVGTNNGGVQIWDAAHCKQVRTMEGHCTRVGTLA 
               
               
                   
                   
                 WNSHILSSGGRDRNILQRDIRAQDDFVSKFSGHKSEVCGLKWSYDNRELASGGN 
               
               
                   
                   
                 DNQLFVWNQQSQQPVLKYNEHTAAVKAIAWSPHQHGLLASGGGTADRCIRFWNT 
               
               
                   
                   
                 ATNTSLNCVDTGSQVCNLVWSKNVNELVSTHGYSQNQIIVWRYPTMSKLATLTG 
               
               
                   
                   
                 HTLRVLYLAISPDGQTIVTGAGDETLRFWNVFPSSKTQQNTIRDMGVWSSGRTH 
               
               
                   
                   
                 IR 
               
               
                   
               
               
                 475 
                 WD40 repeat 
                 MAGGQGEGEEKVDKLSMELTEDVMKSMEIGAVFKDYNGKINSLDFHRTNNYLVT 
                 263 
                 1309 
               
               
                   
                 protein 
                 ASDDEAIRLFDTASATWQKTSYSKKYGVDLICFTNHQTSVLYSSKNGWDESLRH 
               
               
                   
                   
                 LSLMDNKYLRYFKGHHDRVVSLCMSPKGECFMSGSLDRTVLLWDLRIDKCQGLI 
               
               
                   
                   
                 RVRGRPAVAYDEQGLVFAISNEGGLIKMFDARLYDKGPFDTFVVEGDKSEASGI 
               
               
                   
                   
                 KFSNDGKLILLSTMDSNIHVLDAYQGTTVHSFSVEAVPNGGEAVPNGGTLEASF 
               
               
                   
                   
                 SPDGKFVISGSGNGNIHAWSVNSGKEVACWTTEGVIPAVVKWAPRRLMFASGSS 
               
               
                   
                   
                 VLSLWVPDLSKLASLTGSNSNSAY 
               
               
                   
               
               
                 476 
                 WD40 repeat 
                 MHRVGSTGNTSNSSRPRREKRLTYVLNDANDSRHCSGINCLVISKLSLLGGNDY 
                 232 
                 2529 
               
               
                   
                 protein 
                 LFSGSRDGTLKRWELADDSAVCSATFESHVDWVNDAVLTGETLVSCSSDTTLKT 
               
               
                   
                   
                 WRPFSDGVCTRTLRQHSDYVTCLAAASKNSNIVASGGLGREVFIWDIEAAMAPV 
               
               
                   
                   
                 SRTSEAMDDDTSNGVLSSGNSVLSTTVRSTNATNSASLHTSQLQGYTPIAAKGH 
               
               
                   
                   
                 KESVYALAMNDVGTLLVSGGTEKVVRVWDPRSGAKQMKLRGHTDNVRALILDST 
               
               
                   
                   
                 GRFCLSGSSDSIIRLWDLGQQRCVHSYAVHTDSVWALASTPNFSHVYSGGRDLS 
               
               
                   
                   
                 LYLTDLTTRESLLLCMEKHPLLRLTLQDDSIWVATTDSSLHRWPAEGQNPPKMF 
               
               
                   
                   
                 QRGGSFLAGNLSFTRARACLEGSAPVPVNTQPSFVIPGSPGIVQHEILNNRRHV 
               
               
                   
                   
                 LTKDAEGTVKLWEITRGAVLDDYGKVSFEEKKEELFEMVSIPAWFTMDTRLGSM 
               
               
                   
                   
                 SVHLDTPQCFTAEMYAVDLNVPDAPEEQKINLAQETLRGLLAHWLSRRRQRLAT 
               
               
                   
                   
                 QASANGDFPAGQENALRNHISSRIDVHDDAETHIAGILPAFDFSTTSPPSIITE 
               
               
                   
                   
                 GSQGGPWRKKITDLDGTEDEKDFPWWCLECVLHGRLSPRESLKCSFYLHPYEGT 
               
               
                   
                   
                 TVQVLTQGKLSAPRILRIQKVINYVLEKMVLDRPLDSSNSETTFTPGLSGNQSH 
               
               
                   
                   
                 AAVVGDGSLRSGARVWQQKAKPLVEILCNNQVLSPDMSLATVRTYIWKKPDDLY 
               
               
                   
                   
                 LYYRLVQNR 
               
               
                   
               
               
                 477 
                 WD40 repeat 
                 MMKGKTIQMQAAHQNHDGETSVACVLWDWHAKHLITAGADNTILIHSYPSSSSS 
                 56 
                 2950 
               
               
                   
                 protein 
                 KPITLRHHKNAVTALAINSNVRSLASGSVDHSVKLYSYPGGEFQSNVTRFTLPI 
               
               
                   
                   
                 RSLAFNKSGELLAAAGDDEGIKLISTIDNSIARVLKGHNGPVTSISFDPKNEFL 
               
               
                   
                   
                 ASSDSDGTVIYWELSTGKPVHTLKKIAPNTTSNPTSLNQISWRPDGEMLAVPGR 
               
               
                   
                   
                 KSEVSMYDRDTAEKLFSLKGGHSDTICSLAWSPNGKYIATAGTDRQVMVWDADR 
               
               
                   
                   
                 RQDIDKQRFDNPICSVAWKPSDNALAVIDVLGRFGVWESPIASHMKSPADGAER 
               
               
                   
                   
                 YDNMEDEEPLMARYEEELEDSVSGSLNEIINDDDDDDEMGKIPRKILQKKPSVK 
               
               
                   
                   
                 VEKGKEESNAKAFKSGQDSFKLKSAMQEAFQPGATQRQSGKRNFLAYNMLGSVI 
               
               
                   
                   
                 TFDNDGFSHIEVDFHDIGKGCRVPSMTDYFGFTMASLSESGSVFGSPQKGEKNP 
               
               
                   
                   
                 STLMYRPFSSWANNSEWSMRFPMGEEVKAVALGSGWVAAVTSLNFLRVFSEGGL 
               
               
                   
                   
                 QKFVLSMDGPVVTAAGYENLLVVVSHASNPLLSGDQVLSFTVYDISQKTCPLSG 
               
               
                   
                   
                 RLPLSPGSHLTWLGFSEEGLLSSYDSEGNLRVFTNDYNGCWVPIFSAARERKSE 
               
               
                   
                   
                 TESIWMVGLNSTQVFCVVCKLPDTYPQVAPKPVLSVLNLSLPLACSDLGADDLE 
               
               
                   
                   
                 NEYLRGSLLLSQMQKKAEDAVACGRESNMEEDSIFKMEAALDRCLLRLIANCCK 
               
               
                   
                   
                 GDKLVRATELARLLSLEKSLQGAIKLVSAMKLPMLAERFNTILEEKILQENMET 
               
               
                   
                   
                 ISCRRLTSEAQDMDTPISISVKQVSYGANLGDSPFLPNRQVEPKHSTPVFSKPD 
               
               
                   
                   
                 TKIEVDTSEAIAKGCDAQNGNIKSGDAEVQPASHNDSIQKPSNPFAKASNTSAN 
               
               
                   
                   
                 QAVQRNASLLSSIKQMKTATENEGKRKERARSGSLPQKPAKQSKIS 
               
               
                   
               
               
                 478 
                 WD40 repeat 
                 MKQKRKGHQVDDPKYSVQTPQEDDTPNESGPASEEVESSDEEGGNSSNIEDDII 
                 193 
                 2577 
               
               
                   
                 protein 
                 YSSSEEDPVVSSDYEEDEDAESDAEGVTAEQELEGDIDNALQNYMGTLTVLSNF 
               
               
                   
                   
                 HGENLKNAEGEDTSGDDDDEEEMPKRAEESDSPEDENDERPKRAEESDFSEDED 
               
               
                   
                   
                 EERPKRAEESDSSEDEVPSRNTVGDVPLRWYKDEQHIGYDIKGKKIKKQPKKDQ 
               
               
                   
                   
                 LDSFLASTDDSSDWRKVYDEYNDEEVELTKDEIKFISRLRKGTIPHADVNPYEP 
               
               
                   
                   
                 YVDWFDWKDKGHPLSNAPEPKRRFIPSKWEAKKVVKLVRAIRKGWITFQKAEEK 
               
               
                   
                   
                 PRFYLMWGDDLKPSEKMANGLSYIPAPKPKLPGHEESYNPPPEYIPTQEEINSY 
               
               
                   
                   
                 QLMYEEDRPKFIPKRFDSLRNVPAYDRFLSEIFERCLDLYLCPRTRKKRINIDP 
               
               
                   
                   
                 ESLIPKLPKPKDLQPFPSICFLEYKGHTGAVSCISPESSGQWLASGSKDGTVRI 
               
               
                   
                   
                 WEVETARCLKVWDIGRPIQHIAWNPVSQLSILAVAVDEEVLVLNTGLGSEDSQE 
               
               
                   
                   
                 KVAELLHVKSKPVSADDLGDNTSLTKWIKHEKFDGIKLTHLKPVHLISWHHKGD 
               
               
                   
                   
                 YFATVAPDGNTRAVLVHQLSKQQTQNPFKKMQGRVVHVLFHPSRAIFFVATKTH 
               
               
                   
                   
                 VRVYDLVKQQLVKRLVTGLHEVSSMAVHHKGDNLLVGSKEGKVCWFDMDLSTQP 
               
               
                   
                   
                 YKTLKNHSKDIHSVAFHDSYPLFASCSDDCKAYVFYGLVYSDLLQNPLIVPLKV 
               
               
                   
                   
                 LQGHQSVNGMGVLDCQFHPKQPWLFTAGADSVVKLYCN 
               
               
                   
               
               
                 479 
                 WD40 repeat 
                 MMSLKRGFEESLVPAKRQKTELSTVTYGDGPRRTSSLESPIMLLTGHHAAIYTM 
                 187 
                 1233 
               
               
                   
                 protein 
                 KFNPTGTVIASGSHEREIFLWNVHGDCKNFMVLKGHKNAVLDLHWTTDGCQIIS 
               
               
                   
                   
                 ASPDKTLRAWDVETGKQIKKMAEHSSFVNSCCPSRRGPPLVVSGSDDGTAKLWD 
               
               
                   
                   
                 LRHRGAIQTFPDKYQITAVGFSDAADKIYSGGIDNEIKVWDLRRGEVTMRLQGH 
               
               
                   
                   
                 TDTITGMQLSSDGSYLLTNSMDCSLRIWDMRPYAPQNRCVKILTGHQHNFEKNL 
               
               
                   
                   
                 LKCSWSSDGSKVTAGSADRMVYIWDTTTRRILYKLPGHTGSVNETGFHPTQPII 
               
               
                   
                   
                 GSCSSDKQIYLGEIEPNVGYQAVI 
               
               
                   
               
               
                 480 
                 WD40 repeat 
                 MEFSDTYKHTGPCCFSPDARYLAIAVDYRLVIRDVVTLKVVQLYSCMDKISNIE 
                 51 
                 1436 
               
               
                   
                 protein 
                 WALDSEYILCGLYKRAMVQAWSLSQPEWTCKIDEGPAGIAHARWSPDSRHIITT 
               
               
                   
                   
                 SDFQLRLTVWSLVNTACIHIQWPKHASKGVSFTQDGKFAAIATRRDCKDYVNLL 
               
               
                   
                   
                 SCHTWEVMGTFTVDTIDLADLEWSPNDSAIVVWDSPLEYKVLIYSPDGRCLFKY 
               
               
                   
                   
                 QAYDSWLGVKTVAWSPCSQFLAVGSYDQTLRTLNHLTWKPFAEFVHVSTVRGPA 
               
               
                   
                   
                 SAVVFKEVEEPWNLDVSGLHLNDDNAHDIQDGKPAEGHSRVRYKVVEFPVNVSS 
               
               
                   
                   
                 QKHPVDKPNPKQGIGLLAWSRDSQYLFTRNDNMPTALWIWDICRLELAALLIQK 
               
               
                   
                   
                 EPIRAAAWDPVYPRVALCTGSSHLYMWTPSGACCVNIPLPQFVVSDLKWNPDGT 
               
               
                   
                   
                 SMLLKDRESFCCTFVPMLPEFNDDETNEE 
               
               
                   
               
               
                 481 
                 WD40 repeat 
                 MAKLIETHSCVPSTERGRGILIAGDAKTNSIIYCNGRSVIMRNLDNPLEASVYG 
                 525 
                 2351 
               
               
                   
                 protein 
                 EHSYPATVARFSPNGEWVASGDTSGTVRIWGRGSDHTLKYEYKALAGRIDDLEW 
               
               
                   
                   
                 SADGQRIVVCGDSKGKSMVRAFMWDSGTNVGEFDGHSRRVLSCSFKPTRPFRVA 
               
               
                   
                   
                 TCGEDFLVNFYEGPPFRFKTSHRDHSNYVNCVRFAPDGSKFITVGSDRKGVIFD 
               
               
                   
                   
                 GKMGEKIGELSKEGGHTGSIYAASWSPDSKQVLTVSADKSAKIWEISETGNGTV 
               
               
                   
                   
                 KKTLTFGSQGGADDMLVGCLWLNDYLITVSLGGIVSLLSAVDPDKPPKTISGHM 
               
               
                   
                   
                 KSINAIALSLQSGQSEVCSSSYDGVIVRWILGVGYAGRVERKDSTQIKCLATIE 
               
               
                   
                   
                 GELVTCGFDNKVRRVPLLSEQHKESEPIDIGAQPKDLDVAVGCPELTFVSTDAG 
               
               
                   
                   
                 IIIIRASKIVSTTNVGYAVTAAAISPDGTEAVVGGQDGKLRVYSIKGDTLLEES 
               
               
                   
                   
                 VLERHRGPINAIRFSPDGSMFASGDLNREAVVWDRITREVKLKNMVYHTARINC 
               
               
                   
                   
                 IAWSPDSSKVATGSLDTCILIYEVGKPASSRITIKGAHLGGVYGLAFSDQSTVI 
               
               
                   
                   
                 SAGEDACVRVWSLP 
               
               
                   
               
               
                 482 
                 WD40 repeat 
                 MPQPSVILATAGYDHTVRFWEATSGRCYRTLQYPDSQVNHLEITPDKQYLAAAG 
                 152 
                 1099 
               
               
                   
                 protein 
                 NPHIRLFEVNSNNPQPVISYDSHTNNVTAVGFQCDGKWMYSGSEDGTVKIWDLR 
               
               
                   
                   
                 APGFQREYESRAAVNTVVLHPNQTELISGDQNGNIRVWDLNANSCSCELVPEDT 
               
               
                   
                   
                 AVRSLTVMWDGSLVVAANNHGTCYVWRLMRGTQTMTNFEPLHKLQAHNSYILKC 
               
               
                   
                   
                 LLSPEFCEHHRYLATTSSDQTVKIWNVDGFTLERTLTGHQRWVWDCVFSVDGAF 
               
               
                   
                   
                 LVTASSDSTARLWDLSTGEAIRTYQGHHKATVCCALHDGTDGASC 
               
               
                   
               
               
                 483 
                 WD40 repeat 
                 MLTKFETKSNRVKGLSFHPKRPWILASLHSGVIQLWDYRMGTLIDKFDEHDGPV 
                 470 
                 4114 
               
               
                   
                 protein 
                 RGVHFHKTQPLFVSGGDDYKIKVWNYKMRQCLFTFVGHLDYIRTVHFHNEYPWI 
               
               
                   
                   
                 VSASDDQTIRLWNWQSRVCISVLTGHNHYVMSASFHPKEDLVVSASLDQTVRVW 
               
               
                   
                   
                 DISGLRKKTVSPADDLSRLAQMNTDLFGGGDVVVKYVLEGHDRGVNWAAFGTSL 
               
               
                   
                   
                 PLIVSGADRQVGKLWRMNDTKAWEVDTLRGHTNNVSCVIFHARQDIIVSNSEDK 
               
               
                   
                   
                 SIRVWDMSKRTSVQTFRREHDRFWILAAHPEMNLLAAGHDSGMIVFKLERERPA 
               
               
                   
                   
                 YVVYGGSLLYVKDRYLRTYEFATQKDNPLIPIRKPGSIGPNQGPRSLSYSPTEN 
               
               
                   
                   
                 AILICSDADGGAYELYAVPKDSHGRSDTVQEAKKGLGGSAVGVARNRFAVLDKN 
               
               
                   
                   
                 HNQVTIKNLKNEVTKKFDLPVTADALFYAGTGNLLCRSEDSVFLFDMQQRTVLG 
               
               
                   
                   
                 EIQTPNVRYVVWSNDMENVALLSKHTIIIASKKLSSTCSLHETIRVKSGAWDDN 
               
               
                   
                   
                 GIFMYSTLNHIKYCLPNGDSGIIKTLDVPVYITKVSGKSLYCLDRDGKNRVIQI 
               
               
                   
                   
                 DITECLFKLALSKKKYDYVINMIRNSQLCGQAIIAYLQQKGFPEVALHFVRDER 
               
               
                   
                   
                 TRFNLAVESGNIEIAVASAKEIDEKDHWYRLGVEALRQGNAGIVEYAYQRTKNF 
               
               
                   
                   
                 ERLSFLYLITGNLDKLSKMLRIAEMKNDVMGQFHNALYLGDIQERIKILEESGH 
               
               
                   
                   
                 LHLAYATASLHGLADIADRLAADLGGNIPVLPPGKKSSLLMPPAPILHGGDWPL 
               
               
                   
                   
                 LRVTKGIFEGGLENSTSAAYEEEDEEAAADWGEDIDIENIEGENGEATVLDDQE 
               
               
                   
                   
                 VKGGEDDEGGWDMEDLELPPDVAAANVGTNQKTLFVAPTLGMPVSQIWMQKSSL 
               
               
                   
                   
                 AGEHAAAGNFETALRLLTRQLGIKNFSPLKPLFLELYMGSHTFLPSFASVPAFS 
               
               
                   
                   
                 LALQRGWSESASPNIRGPPALVYRLSVLEEKLTVAYRATTEGRFSEALRLFLNI 
               
               
                   
                   
                 LHTIPVIVVDSRKEIDEVKELIGIAKEYVLGLRMEVKRKEIRDDAVRQQELAAY 
               
               
                   
                   
                 FTHCNLQKAHLKLALLNAMGISYRCKNYNTAANFARRLLETDPSSNHATKARQV 
               
               
                   
                   
                 LQVCERNLQDATQLNYDFRNPFVVCGATFTPIYRGQKEVSCPYCMARFVPDIAG 
               
               
                   
                   
                 KLCSICDLAIVGSDASGLFCFATQTR 
               
               
                   
               
               
                 484 
                 WD40 repeat 
                 MDLLQNYQDDSEDSNPELRNHPPLEDATATSAPAGVENETSSSPDSSPLRLALP 
                 196 
                 2007 
               
               
                   
                 protein 
                 AKSCAPDVDETLMALGVPGSEKKNNHNKPIDPTQHSVTFNPSYDQLWAPLYGPA 
               
               
                   
                   
                 HPYAKDGIAQGMRNHKLGFVEDSAIEPFMFDEQYNTFHRYGYAADPSASLGSHI 
               
               
                   
                   
                 VGDLESLKKNDGASVYNLPKREHKRQKLEKKMIQKDENEEEEKEVGEEVDNPST 
               
               
                   
                   
                 EEWLKKNRKSPWAGKKEGLQTELTEEQKKYAQEHAEKKGDREKGEKVEIVDKTT 
               
               
                   
                   
                 FHGKEERDYQGRSWIDPPKDAKATNDHCYIPKRWVHTWSGHTKGVSAIRFFPKY 
               
               
                   
                   
                 GHLLLSAGMDTKVKIWDVFNSGKCMRTYMGHSKAVRDISFSNDGSRFLSAGYDR 
               
               
                   
                   
                 NIKLWDTETGKVISTFSTGKIPYVVKLHPDEDKQNVLLAGMSDKKIVQWDMNSG 
               
               
                   
                   
                 EITQEYDQHLGAVNTITFVDNNRRFVTSSDDKSLRVWEFGIPVVIKYISEPHMH 
               
               
                   
                   
                 SMPSISLHPNTNWLAAQSLDNQILIYSTRERFQLNKKKRFAGHIAAGYACQVNF 
               
               
                   
                   
                 SPDGRFVMSGDGEGRCWFWDWKTCKVFRTLKCHDNVCIGCEWHPLEQSKVATCG 
               
               
                   
                   
                 WDGMIKYWD 
               
               
                   
               
               
                 485 
                 WD40 repeat 
                 MARKGLGTDPAIGSLMSSKKRKEYKVTNRFQEGKRPLYAIAFNFIDARYHNIFA 
                 214 
                 1323 
               
               
                   
                 protein 
                 TAGGTRVTIYQCLEGGAISVLQAYVDDDKDESFYTLSWACDVNGSPLLVAGGHN 
               
               
                   
                   
                 GIIRVLDVANEKVHKSFVGHGDSVNEIRTQALKPSLILSASKDESVRLWNVQTG 
               
               
                   
                   
                 ICILIFAGAGGHRNEVLSVDFHPSDVYRIASCGMDNTVKIWSMKEFWTYVEKSF 
               
               
                   
                   
                 TWTDLPSKFPTKYVQFPVFIAAVHSNYVDCTRWLGNFILSKSVDNEVVLWEPYS 
               
               
                   
                   
                 KEQSTSDGVVDILQKYPVPECDIWFIKFSCDFHYNSMAVGNREGKVYVWELQSS 
               
               
                   
                   
                 PPNLIARLSHAHCKNPIRQTAISHDGSTILCCCDDGSMWRWDVVQ 
               
               
                   
               
               
                 486 
                 WD40 repeat 
                 MESGAGGSVGARVPSAKPEMLQQPPYSNGDDDNDMERGTAPVPSSNPNTVSKWE 
                 68 
                 2146 
               
               
                   
                 protein 
                 LDKDFLCPICMQTMKDAFLTACGHSFCYMCIMTHLNNKSNCPCCSLYLTNNQLF 
               
               
                   
                   
                 PNFLLNKLLKKTSACQMASTASPVENLCLSLQQGAEVSVKELDFLLTLLAEKKR 
               
               
                   
                   
                 KMEQEEAETNMEILLDFLQRLRQQKQAELNEVQADLHYIKDDILALEKRRLELS 
               
               
                   
                   
                 RARERYSRKLHMLLDDPMDTTLGHAAIDDGNNVRTAFVRGGQGDAISGKFQQKK 
               
               
                   
                   
                 AEIKAQASSQGMQKRANFCHSDSQVLPTLSGLTIARKRRVLAQFDDLQECYLQK 
               
               
                   
                   
                 RRRWATQLRKQCDGGLRKERDGNSISREGYHAGLEEFQSILTTFTRYSRLRVIS 
               
               
                   
                   
                 ELRHGDLFHSANIVSSIEFDRDDELFATAGVSRRIKVFDFATVVNEPADVHCPV 
               
               
                   
                   
                 VEMSTRSKLSCLSWNKCIKSQIASSDYEGIVTVWDVNTRQSVMMYEEHEKRAWS 
               
               
                   
                   
                 VDFSRTEPTRLISGSDDGKVKVWCTRQETSVLNIDMKANICCVKYNPGSSYYVA 
               
               
                   
                   
                 VGSADHHIHYYDLRNPSVPLYEFNGHRKTVSYVKFISTNELASASTDSTLRLWD 
               
               
                   
                   
                 VRDNCLVRTFKGHTNEKNFVGLTVNSEYIACGSETNGVFVYHKAISKPAAWHQF 
               
               
                   
                   
                 GSPDLDDSDDDTSHFISAVCWKSESPTMLAANSQGTIKVLVLAP 
               
               
                   
               
               
                 487 
                 WD40 repeat 
                 MANYVDSKKNFKCVPALQQFYTGGPFRLSSDGSFLVCACNDEVKVVDLATGSVK 
                 874 
                 3705 
               
               
                   
                 protein 
                 NTLEGDSELIVALALTPDNKYLFSASRSTQIKRWDLSSATCKRTWKAHNGPVAD 
               
               
                   
                   
                 MACDASGGLLATAGADRSILVWDVDGGYCTHSFRGHQGVVTTVIFHPDPHCLLL 
               
               
                   
                   
                 FSGSDDATVRIWDLVAKKCISVLEKHFSTVTSLAISENGWNLLSAGRDKVVNIW 
               
               
                   
                   
                 DLRDYHCRATIPTYEPLEAVCVLPTGSRLVSVMNQSRALPENRKKSGAAPVYFL 
               
               
                   
                   
                 TVGERGIVRIWYSEGALCLYEQKSSDAIISSDKDELKGGFVSAVLLPLTQGVMC 
               
               
                   
                   
                 VTADQRFLFYNLDESDEGKCDLKVSKRLIGYNEEIVDLKFLGDEEKFLAVATNL 
               
               
                   
                   
                 EQVRMYDLSSMTCVYELSGHTDIVLCLDTVVFSGHSLLASGSKDHTVRIWDTES 
               
               
                   
                   
                 KSCICVAAGHMGAVGAVAFSKKAKNFFVSGSSDRTIKVWSFASVLDFGGISKSI 
               
               
                   
                   
                 KLSSQAAVAAHDKDINSVAVAPNDSLICTGSQDRTARIWRLPDLVPVLVLRGHK 
               
               
                   
                   
                 RGVWCVEFSPVDQCVMTASGDKTIKIWALSDGSCLKTFEGHTASVLRASFLTRG 
               
               
                   
                   
                 TQFVSSGADGLLKLWTIKSNECIATFDQHEDKIWAMAVGKKTEMLATGGSDSLV 
               
               
                   
                   
                 NLWHDCTTTDEEEALLKEEEAALKDQELLNALADTDYVKAIQLAFELRRPYKLL 
               
               
                   
                   
                 NVFTELYSKGHAQDQIQKVIRELGNEELRLLLEYVREWNTKPKFAHVAQFVLFQ 
               
               
                   
                   
                 LFNVLPPKEIIEVQGISELLEGLIPYAQRHYSRIDRLMRSTFLLDYTLSSMSVL 
               
               
                   
                   
                 SPTETDLSSSNLLARTADPLHAQIDQFHPTHFPEPNLTPIQSLLDSGNTDSVEV 
               
               
                   
                   
                 TARRAKKKRVSGNDSEKTTVAEVKIGDMENAFDEPDVADQGSSRKHKPASSKKR 
               
               
                   
                   
                 KSIAVGNASIKRIASGNAVTIALQV 
               
               
                   
               
               
                 488 
                 WD40 repeat 
                 MESSCSSMNSNRHSTEKRCLRPLQKQGASMNKHSSDRFIPARGSIDLDVARFMV 
                 360 
                 1754 
               
               
                   
                 protein 
                 TQKQKDNNDIHALSPSPSPSKKAYQKEMADTLLKNAGAADNNCRILSFNGKSST 
               
               
                   
                   
                 VSQGSQENVLANLSISRRARRYIPQSADRTLDAPDLLDDYYLNLLDWSSTNVLS 
               
               
                   
                   
                 TALGNTVYLWDASNSSISELLIADEEEGPVTSVSWAPDGSQIAVGLNNSVVQLW 
               
               
                   
                   
                 DSQSNKKLRALKGHHDRVGALSWNGPILTTGGLDGIIINHDVRTRDHIVQTYKG 
               
               
                   
                   
                 HTQEVCGLKWSPSGQQLASGGNDNLLYIWDKSMASHNPSSQYFHQLDEHCAAVK 
               
               
                   
                   
                 ALAWCPFQTNLLASGGGTSDGSIKFWNTQTGACLNTVDTHSQVCSLLWNRHERE 
               
               
                   
                   
                 LLSSHGLNQNQLTLWKYPSMVKITELTGHTARVLHMAQSPDGYTVASAAADETL 
               
               
                   
                   
                 KFWQVFGAPDASKKTKTKDTKGAFNMFHMHIR 
               
               
                   
               
               
                 489 
                 WD40 repeat 
                 MLDEIVADEEEEFNIWKKNTPLLYDVVITHALEWPSLTVQWLPDRHQSPTKDYS 
                 185 
                 1384 
               
               
                   
                 protein 
                 LQKMIVGTHTSGDEPNYLMIAEVQMPLQYSEDGNVGGFESTEAKVHIIQQINHE 
               
               
                   
                   
                 GEVNRAQYMPQNSFIIATKTVSSDVYVFDYTKHSSNAPQERVCNPELILKGHTN 
               
               
                   
                   
                 EGYSLSWSPLKEGQLLSGSNDAQICFWDINAASGRKVVEAKQIFKVHEGAVEDV 
               
               
                   
                   
                 SWHLKHEYLFGSVGDDCHLLIWDTRTAAPNKPQHSVVAHESEVNSLAFNPFNEW 
               
               
                   
                   
                 LLATGSADKTVKLFKLRKLSCSLFTFSNHTEEVFQIEWSPMNETILASSGGDRR 
               
               
                   
                   
                 LMVWDLRRIGDEQTSEDAEDGPPELIFIHGGHTSKISDFSWNLHDDWLIASSAE 
               
               
                   
                   
                 DNILQIWQMAENIYHDDADIL 
               
               
                   
               
               
                 490 
                 WD40 repeat 
                 MTKEDHGESRDEMGERMVNEEYKLWKKNTPFLYDLVITHALEWPSLTVQWLPPS 
                 241 
                 1533 
               
               
                   
                 protein 
                 CKQQQDIIKDDDIDHPNTQMVILGTHTSDNEPNYLILAEVQLHDGTEDEDGDGD 
               
               
                   
                   
                 VKRPQDKMKPGTSGGAMGKVRILQQINHQKEVNRARYMPQKPTIIATKTVNADV 
               
               
                   
                   
                 YVFDYSKHPSKPPQEGRCNPELRLQGHESEGYGLSWSPLKEGHLLSASDDAQIC 
               
               
                   
                   
                 LWDITAATKAPKVVEANQIFRYHDGPVEDVAWHAIHDHLFGSVGDDHHLLLWDI 
               
               
                   
                   
                 RNDSEKPLHIVEAHQAEVNCLAFNPFNEWIVATGSADRTVALHDIRKLDKVLHT 
               
               
                   
                   
                 CAHHMEEVFQIGWSPQNGAILASCGSDRRLMVWDLSRIGDEQNPEDAEEAPPEL 
               
               
                   
                   
                 LFIHGGHTSKISDFSWNPAEEWVIASVAEDNILQVWQMSEHIYNDDNDSPTA 
               
               
                   
               
               
                 491 
                 WD40 repeat 
                 MAMAMGDENAADPVEEFNIWKKNTPFLYDLVITHALEWPSLTVQWLPDRHQSST 
                 230 
                 1435 
               
               
                   
                 protein 
                 ADYSLQKMIVGTHTSEDEPNYLMIAEVQIPLQNSSEDNIIGGFESTEAKVQIIQK 
               
               
                   
                   
                 INHEGEVNKARYMPQNSFVIATKTVSSDVYVFDYSKHPSKAPQERVCNPELILK 
               
               
                   
                   
                 GHSNEGYGLSWSPLKEGYLLSGSNDAQICLWDINAAFGKKVLEANQIFKVHEGA 
               
               
                   
                   
                 VGDVSWHLKHEYLFGSVGDDCHLLIWDMRTAAPNKPQQSVIAHQSEVNSLAFNP 
               
               
                   
                   
                 FNEWLLATGSMDKTVKLFDLRKLSCSLHTFSNHSTDQVFQIEWSPMNETILASSG 
               
               
                   
                   
                 ADRRLMVWDLARIGETPEDEEDGPPELLFVHGGHTSKISDFSWNLNDDRVIASV 
               
               
                   
                   
                 AEDNILQIWQMAENIYHDDEDML 
               
               
                   
               
               
                 492 
                 WD40 repeat 
                 MGLFEPFRALGYITDGVPFAVQRRGIETFVTLSVGKAWQIYNCAKLIPVLVGPQ 
                 101 
                 2857 
               
               
                   
                 protein 
                 MDKKIRALACWRDFTFAATGHDIAVFRRAHQVATWSGHKAKVTLLLSFGQHVLS 
               
               
                   
                   
                 VDLEGCLFIWAVAEVNQNKPPIGQIQLGEKFSPSCIMHPDTYLNKVLIGSEEGT 
               
               
                   
                   
                 LQLWNVNTRKKLYEFKGWGSSIRCCVSSPALDVVGIGCSDGKIHVHNLRYDEEI 
               
               
                   
                   
                 VTFMHSTRGAVTALSFRTDGQPLLAAGGSSGVISIWNLEKKKLQSVIKDAHDSS 
               
               
                   
                   
                 VCSLHFFANEPVLMSSATDNSIKMWIFDTTDGEARLLKYRSGHSAPPMCIRYYG 
               
               
                   
                   
                 KGRHILSAGQDRAFRIFSVIQDQQSRELSQGHVGKRAKKLKVKDEEIKLPPVIA 
               
               
                   
                   
                 FDAAEIRERDWCNVVTCHLDDPCAYTWRLQNFVIGEHILKPCLEDPTPVKSCSI 
               
               
                   
                   
                 SACGNFAVLGTEGGWLERFNLQSGISRGTYIDIGEKRQCAHNGAVVGLACDATN 
               
               
                   
                   
                 TLLISGGYNGDIKVWDFKGRELKFRWEIEVPLIKIVYHPGNGILATAADDMILR 
               
               
                   
                   
                 LFDVTAMRLVRIFVGHMDRVTDLCFSGDGKWLLSSSMDGTIRVWDIISSRQLNA 
               
               
                   
                   
                 MHMDSAVTALSLSPGMDMLATTHVGHNGIYLWANRMIYSKATDIEPFISGKQVV 
               
               
                   
                   
                 KVSMPTVSSKRESEEGDEKRTIVAESNVNKSDVSGSLIGDSYSAQLTPELVTLA 
               
               
                   
                   
                 LLPKAQWQSLVNLDIIKMRNKPIEPPKKPEKAPFFLPSLPTLSGERIFIPSSMN 
               
               
                   
                   
                 GDGDQDETRNDKTVFEARGKKLGGESLSFMQLLQSCAKIKDFTTFTNYLKGLSP 
               
               
                   
                   
                 SAVDMELRLLQIVDNENISETEHSVELQGIGMLLDYFVNEVSCNNNFEFVQALI 
               
               
                   
                   
                 RLFLKIHGETIRCQVSLQEKARKLLEIQSSTWERLDTSFQNARCMITFLSSSQF 
               
               
                   
               
               
                 493 
                 WD40 repeat 
                 MIAAVCWVPKGVAKVLPDSAEPPTQEEIQELLKCNVVAESDDNEDSDEESEEMD 
                 43 
                 1548 
               
               
                   
                 protein 
                 TETDKNTDAVAKALAAANALGSQSSDFQRQHKVDDIANGLKELDMDHYDDEDEG 
               
               
                   
                   
                 IDIFGSGSLGNCYYPANDMDPYLVEQDDDDEDEIEDMTIKPSDLIILSARNEDD 
               
               
                   
                   
                 VSHLEVWIYEEETEEGGSNMYVHHDIILPAFPLSLAWLDCNLKGGEKGNFVAVG 
               
               
                   
                   
                 TMQPEIELWDLDVLDEVEPAVVLGGAVKDEASGKTTKLKKKKKNKQAVNFKEGS 
               
               
                   
                   
                 HTDAVLGLAWNMEYRNVLASASADKSVKIWDIVAEKCEHTMQPHTDKVQAVAWN 
               
               
                   
                   
                 PNQATVLLSGSFDRSVIMMDMRAPTHSGIRWPVPADVESLAWDPHTDHSFMVSA 
               
               
                   
                   
                 EDGTVRGFDIRAAASTADFDGKPMFILHAHDKAVCAISYNPAAPSLLTTGSTDK 
               
               
                   
                   
                 MVKLWDITNNQPSCIASTNPNVGAVFSAAFSKNSPFLLATGGSKGILHVWDTLD 
               
               
                   
                   
                 NSEVARRFGKFRPQN 
               
               
                   
               
               
                 494 
                 WEE1-like 
                 MIMDENEFCDIFSLRKRLCLLSSQEGEEEEELEAMSQLDAGEFTVTGNEEVVAI 
                 206 
                 1657 
               
               
                   
                 protein 
                 AEDDVNTGILSQDLFSSQDYCTPSQPQDSTDLDSKDKAPCPLSPVKSTIQRKRC 
               
               
                   
                   
                 RPELLSNPPDSIQFSFQRLERVRSEESIQSSSQQLARVRSEVSSSDDFKTPKIT 
               
               
                   
                   
                 ASGQKNYVSQSALALRARVMSPPCIKNPYLDENEELNEKIQRSTRRSPACVTPI 
               
               
                   
                   
                 QSGACLSRYRADFHELEEIGRGNFSRVYKALNRLDGCCYAVKCSQSELRLDTER 
               
               
                   
                   
                 KVALMEVQSLAALGPHKNIVGYHTAWFENDHLYIQMELCDHNLTTANDRGILRT 
               
               
                   
                   
                 DTDFLEAVYQIAQALEFIHGRGVAHLDVKPENIYVRDGTYKLGDFGRATLINGT 
               
               
                   
                   
                 LHVEEGDARYMSREILNDNYEHLDKVDMFSLGATFFELLMRKQYPGSGKRIDRD 
               
               
                   
                   
                 TEIKIPILPGFSIYFQKLLQDLVSNDPGKRPSAKDVLKNPIFNKVRGAKEV 
               
               
                   
               
               
                 495 
                 WD40 repeat 
                 MLAPALEMEPVEPQSLKKLSFKSLKRALDLFSPVHGQIAPPDPESKKMRISYSL 
                 117 
                 1580 
               
               
                   
                 protein 
                 NFEYGGGSGSEDQVPKRKESGAAQNQGQQAAGASNALALPGPEGSKIPPMEKSQ 
               
               
                   
                   
                 NALTVGPSLRPQGLNDVGLHGKGTAIISASGSSDRNLSTASAIMERLPSRWPRPV 
               
               
                   
                   
                 WHPPWKNYRVISGHLGWVRSIAFDPSNQWFCTGSADRTIKIWDLASGRLKLTLT 
               
               
                   
                   
                 GHIEQIRGLAVSSKHTYMFSAGDDKQVKCWDLEQNKVIRSYHGHLSGRLKLTLT 
               
               
                   
                   
                 PTIDILLTGGRDSVCRVWDIRSKMQIFALSGHDNTVCSVFARPTDPQVVTGSHD 
               
               
                   
                   
                 TTIKFWDLRHGKTMTTLTNHKKSVRAMAQHPKENCFASASADNIKKFQLPRGEF 
               
               
                   
                   
                 LHNMLSQQKTIINTMAVNEEGVMATGGDNGSLWFWDWKSGHNGQQAHTIVQPGS 
               
               
                   
                   
                 LESEAGIYALSYDLTGSRLVSCEADKTIKMWKEDELATPETHPLNFKPPKDIRRF 
               
               
                   
               
               
                 496 
                 WD40 repeat 
                 MEEAAKEQSAGSGKPKLLRYGLRSAAKPKEDKKEEQLHQPPPPPPPQQQAAPAP 
                 111 
                 1700 
               
               
                   
                 protein 
                 APAATRSSTSGSAGGRDRRPQQQHAVDEKYARWKSLVPVLYDWLANHNLLWPSL 
               
               
                   
                   
                 SCRWGPQLEQATYKNRQRLYISEQTDGSVPNTLVIANCEVVKPRVAAAEHVSQF 
               
               
                   
                   
                 NEEARSPFIRKYKTIIHPGEVNRIRELPQNPNIVATHTDSPDVLIWDVESQPNR 
               
               
                   
                   
                 HAVYGATASRPNLILTGHQENAEFALAMCPAEPFVLSGGKDKTVVLWSIQDHIT 
               
               
                   
                   
                 ASATDQTTNKSPGSGGSIIKKTGEGNEETGNGPSVGPRGIYCGHEDTVEDVAFC 
               
               
                   
                   
                 PSTAQEFCSVGDDSCLILWDARIGTNPVAKVEKAHNGDLHCVDWNPHDNNLILT 
               
               
                   
                   
                 GSADNSVNMFDRRNLTSNGVGSPVYKFEGHKAAVLCVQWSPDKPSVFGSSAEDG 
               
               
                   
                   
                 LLNIWDYERVDKKVDRAPNAPAGLFFQHAGHRDKIVDFHWNTADPWTMVSVSDD 
               
               
                   
                   
                 CDTAGGGGTLQIWRMSDLIYRPEEEVLAELENGKAHVLECSKA 
               
               
                   
               
               
                 497 
                 WD40 repeat 
                 MAKDEEEFRGEMEERLVNEEYKIWKKNTPFLYDLVITHALEWPSLTVQWLPDRE 
                 144 
                 1412 
               
               
                   
                 protein 
                 EPPGKDYSVQKMILGTHTSDNEPNYLMLAQVQKOKEDAENDARQYDDERGEIGG 
               
               
                   
                   
                 EGCANGKVQVTQQTNHDGEVNEARYYIPQNPETTATKTVSAEVYVEDYSKHPSKP 
               
               
                   
                   
                 PQDGGCHPDLRLRGHNTEGYGLSWSPFKHGHLLSGSDDAQICLWDINVPAKNKV 
               
               
                   
                   
                 LEAQQIFKVHEGVVEDVAWHLRHEYLFGSVGDDRHLLIWDLRTSATNKPLHSVV 
               
               
                   
                   
                 AHQGEVNCLAFNPFNEWVLATGSADRTVKLFDLRKISSALHTFSCHKEEVFQIG 
               
               
                   
                   
                 WSPKNETILASCSADRRLMVWDLSRIDEFQTPEDALDGPPELLFIHGGHTSKIS 
               
               
                   
                   
                 DFSWNPCEDWVIASVAEDNILQIWQMAENIYHDEEDDMPPEEVV 
               
               
                   
               
               
                 498 
                 Cyclin- 
                 MGKYMRKGKGVGEVAVMEVSQGSLGVRTRARTLAAASSQKDHRRLGASKSVTTK 
                 793 
                 1683 
               
               
                   
                 dependant 
                 HQSSAPPASPCVESSMHTCYLELRSRKLEKFSRCYHSAHGATSHGESKRSLSLS 
               
               
                   
                 kinase 
                 EPSRLAVSEEARVASDKSSHRVLQQQSSVAHSRNNASATFSHNAKPAKAAQRKER 
               
               
                   
                 inhibitor 
                 RDDDHTSARPSEAPHEDEDGMEVEASFGENVMDLDSRERRTRETTPSSYTRDVE 
               
               
                   
                   
                 TMETPGSTTRPPSNAGRRRFQTEGGHGTRNQFHVPTTNEIEEFFAGAEQQEQRR 
               
               
                   
                   
                 FTDRYNYDPVSDSPLPGRFEWVRLRP 
               
               
                   
               
               
                 499 
                 CDK type D 
                 MQNMEENVQSSWSLHGNKEICARYEILKRVSSGTYLDVYRGRRKEDGLIVALKE 
                 415 
                 2196 
               
               
                   
                   
                 VHDYQSSWREIEALQRLCGCPNVVRLYEVILEFLTSDLYSVIKSAKKNKGENGIP 
               
               
                   
                   
                 EAEVKAWMIQILQGLANCHANWVIHRDLKPSNMLISAYGILKLADFGSMSFLKR 
               
               
                   
                   
                 AIYEVEYELPQEDILADAPGERLMDEDDSVKGVWNEGEEDSSTAVETNFDDMAE 
               
               
                   
                   
                 TANLDLSWKNEGDMVMQGFTSGVGTRWYRAPDFLYGATIYGKEIDLWSLGCILG 
               
               
                   
                   
                 ELLILEPLFSGTSNIDOLSRLVKVLGLQQKKNWPGCSNLPDYRKLCFPGDGSPV 
               
               
                   
                   
                 GLKNHVPNCSDNMFSILERLVCYDPAARLNAKEIVENKYFVEDPYPVLTHELRV 
               
               
                   
                   
                 PSPLREENNFSEDWAKWKDMEVDSDLENIDEFNVVHSSDGFCIKFS 
               
               
                   
               
               
                 500 
                 Histone 
                 MAPVKRIEPEKTKANEGKPKRRKVAFAIDTGIEANDCISLHLVSTPEEMRDAEG 
                 109 
                 1653 
               
               
                   
                 acetyltransferase 
                 VEDQSLSFNPEYMQHFVGEHGKIYGYKGLKIDVWLNALSFHAYVDIQYESKVEE 
               
               
                   
                   
                 GKSEKEATDLTDIMKRIFGRGLVEDRNAFIQSFSSNSQSIESMIHNEGERIATR 
               
               
                   
                   
                 EILTDKGLSAQGDSERLGVSNEIFRLELSDPQIREWHARLEPLVLLFVEGSQPI 
               
               
                   
                   
                 EQDDPKWEMYIRVQRESLSGGSAVCRLLGFCTVYRFYHYPDTTRLRISQILVFP 
               
               
                   
                   
                 PYQGKGHGLLLLEAVNKTAVSRDSYDVTVEEPSESLQELRDCMDTIRISQILVFP 
               
               
                   
                   
                 MPAVKSAVQKLKEANPSDKGAADHCLEGNVNNETVTTSSTKPKNKSGWFPPPGL 
               
               
                   
                   
                 VEEVRKHLKISKKQFKRCWEILLYLNLDRSDSQCEDKYHISLMEQIMSELFDKS 
               
               
                   
                   
                 SEKSAKGKRVIDIDNEYDNSKTFIMVRTRNPGNGEGFLPEALEGGMEVSQEDQL 
               
               
                   
                   
                 KSLFEERLEEIAQIAEKVPSLCKALQMP 
               
               
                   
               
               
                 501 
                 Histone 
                 MPEDRKKILEALAAKRKAEAESGEKKPRQKSSLNPAKPVSKPVSKPVGGIGSKG 
                 343 
                 1023 
               
               
                   
                 deacetylase 
                 KSTSAPISSTKAKSKHKEEVKAKRVTKMDRYETDEDDESEEEEDLDSESDDDEL 
               
               
                   
                   
                 SDEDSEDDIKSKSVKKLPPQSKGKAPVKGISSSNGKGRDEKGKGIMKDKGKAKA 
               
               
                   
                   
                 KVEESSSDAEGDSDDDGGDLSDDPLQEVDPSNILPSKTRREASQPTNYQFANMS 
               
               
                   
                   
                 GDDDDDDDSD 
               
               
                   
               
               
                 502 
                 Histone 
                 MADVPESLQQEKDEQGTDKNCCDGKFQKEIDIDDMEEEYNESSIDDEEENLSDN 
                 417 
                 2351 
               
               
                   
                 deacetylase 
                 VATNNMGTIPQGQACMAVTVEGIEHANSVGCGRNGREGSEEVTAAEDMGHVSIE 
               
               
                   
                   
                 NIREQGRNRKSSEQLLALYEQEGLLEDDEDDDDVDWEPFEGVTVQMKWYCTNCT 
               
               
                   
                   
                 MANSDDSVHCDSCGEHRNSDILRQGFLASPYLPAESPSSSDVPDERLEESKCVM 
               
               
                   
                   
                 TTLTPSISPMIGVCCSSLQSERRTVVGFDERMLLHSEIQMETYPHPERPDRLRA 
               
               
                   
                   
                 IAASLRAAGLFPGKCFSIPAREATCEELQTIHSLEHVNAVESTSCGMLSHLSPD 
               
               
                   
                   
                 TYANEHSSLAARLAAGLCADLAKAIMTGQAQNGFALVRPPGHHAGVKDSMGFCL 
               
               
                   
                   
                 HNNAAIAVSASRVVGAKKVLIVDWDVHHGNGTQEIFEADQSVLYISLHRHGEGF 
               
               
                   
                   
                 YPGSGAVTEVGSSKGEGYSVNIPWKCGGVGDNDYIFAFQHAVLPIAEQFEPDLT 
               
               
                   
                   
                 IISAGFDAAKGDPLGRCEVTPDGFAHMAQMLSCLSKGKMLVILEGGYNLRSISA 
               
               
                   
                   
                 SATAVIKVLLGDNPKALPIDIQPSKGGLQTLLEVFEIQSKYWSSLKGHDQKLRS 
               
               
                   
                   
                 QWEAQYGSKKRKVIRKRHMHIVGGPVWWKWGRKRVVYYHWFARVSSRKHL 
               
               
                   
               
               
                 503 
                 Peptidylprolyl 
                 MASGAGAAGVVEWHQKPPNPKNPVVFFDVTIGTIPAGRIKMELFADIVPRTAEN 
                 69 
                 641 
               
               
                   
                 isomerase 
                 FRQFCTGEYRKAGIPIGYKGCHFHRVIKDFMIQAGDFVKGDGSGCISIYGSKFE 
               
               
                   
                   
                 DENFIAKHTGPGLLSMANSGPNTNGCQFFLTCAKCDWLDNKHVVFGRVLGEGLL 
               
               
                   
                   
                 VLRKIENVQTGQHNRPKLPCVIAECGEM 
               
               
                   
               
               
                 504 
                 Peptidylprolyl 
                 MAKLVSSVCAFSCQQRHPHSRPRFLSNRDHYNHYHNHSHYHNVCYFPPMMMMQQ 
                 172 
                 1623 
               
               
                   
                 isomerase 
                 QLQKQKRMTTKTITSLFKCNSSNHTLLKGLKEFMGFKFRLQAAMLSCEMSILGR 
               
               
                   
                   
                 VFAIFFIVHQAAAPFPFNHFDNWLVPPASAVLYSPNTKVPRTGEVALRKSIPAN 
               
               
                   
                   
                 PAMKSIQDFLEDIYYLLRFPQRKPYGTMEGDVKSALQIAINEKDSILGSVPLDM 
               
               
                   
                   
                 KERGLQLYNFLIDGQGGLQVLIEYIKEKDPDKVSVNLSSSLDTIAQLELLQAPG 
               
               
                   
                   
                 LPYLLPEEYQQYPRLNGRATIEFTMEKGDNSMFSVSSGGGLQKTATIQVVLDGY 
               
               
                   
                   
                 SAPLTAGNFTKLVIDGAYNGLKLKTTEQAVISDNERAEAGFNLPIEILPAGGFE 
               
               
                   
                   
                 PLYRTTLSVQDGELPVLPLSVYGAIAMAHNTISEDYSSPSQFFFYLYDKRNAGL 
               
               
                   
                   
                 GGLSFDEGQFSVFGYTTVGKEILPQLKTGDIIKSAKLVDGFDHLVLPSSST 
               
               
                   
               
               
                 505 
                 WD40 repeat 
                 MDHYYQDDFDYLVDDEMVDFADDVEDDVRTRRRSDIDSDSENDFDSNNKSPDTT 
                 231 
                 1768 
               
               
                   
                 protein 
                 ALQAKRGKDIQGIPWNRLNFTREKYRETRLQQYKNYENLPRPRRSRNLDKECTN 
               
               
                   
                   
                 FERGSSFYDFRHNTRSVKATIVHFQLRNLVWATSKHNVYLMQNYSIMHWSSLKQ 
               
               
                   
                   
                 KGEEVLNVAGPIIPSVKHPGSSPQGLTRVQVSAMSVKDNLVVAGGFQGELICKY 
               
               
                   
                   
                 LDKPGVSFCTKISHDENGITNAVEIYNDASGATRLMTANNDLAVRVFDTEKFTV 
               
               
                   
                   
                 LERFSFPWSVNHTSVSPDGKLVAVLGDNADCLLADCKTGKTVGTLRGHLDYSFA 
               
               
                   
                   
                 AAWHPDGYILATGNQDTTCRLWDVRKLSSSLAVLKGRMGAIRSIRFSSDGRFMA 
               
               
                   
                   
                 MAEPADFVHLYDTRQNYTKSQEIDLFGEIAGISFSPDTEAFFVGVADRTYGSLL 
               
               
                   
                   
                 EFNRRRMNYYLDSIL 
               
               
                   
               
               
                 506 
                 WD40 repeat 
                 MDCSGDEEEEQFFESLEEMLSPSDSGSEAADNETGCRNADARSKYEIWKRAPSS 
                 376 
                 2943 
               
               
                   
                 protein 
                 IQERRQRFLVRMGLANPSELGNQVNSTSAESTCSTETANIPNGIERLRENSGAV 
               
               
                   
                   
                 LRTAGSSGRKTHCKNVINIGLREGSVRSSSSSNGTPDVGEDNGEFGGTIFSRSG 
               
               
                   
                   
                 GTWECMCKIKNLDSGKEFVVDELGQDGLWNKLREVGTDRQLTMDEFERSLGLSP 
               
               
                   
                   
                 LVQELMRRESGVAQADCNGVHHHDAEISSSKRRSWLKALKSAAYSMRRPKEDQS 
               
               
                   
                   
                 NYDSERSGRRSGSFDVPWGKPQWTKVRHYRKRYKEFTALYMGQEIEAHEGSIWT 
               
               
                   
                   
                 MKFSLDGRYLASAGQDCVIHVREVIESMRTFGADTPDLYASSAYFSMNGLQELV 
               
               
                   
                   
                 PLSIEDHANKMKRGKIIGSKKSSNSDCIVLPNKVFQLSEEPVCSFHGHLLDVFD 
               
               
                   
                   
                 LSWSPSQYLLSSSMDKTVRLWKLGHESCLKVFSHNDIVTCIQFNPVDERYFISG 
               
               
                   
                   
                 SLDGKARIWSIPDRQVVDWSDLREMVTAVCYTPDGQGGLVGSIKGSCRFYNTSG 
               
               
                   
                   
                 NKLQLENQLNVRSKKKKSSGKKITGFQFAPGGDSQKVLITSADSRVRVYNGSEL 
               
               
                   
                   
                 VCKYKGFRNTCSQISASFAPNGQHFVCASEDSRVYIWNHESPRGSGARHEKSSW 
               
               
                   
                   
                 SHEHFLSQGVSVAIPWSGMKLQPPVWNSPEFMLGQRHNLLSLQGGKDVGCQNGL 
               
               
                   
                   
                 LSREAGEGQESETPLHYISQVSHSCGSQNMVDRDGQDDLSRYSACISDSRLSSF 
               
               
                   
                   
                 MAFPESPGNPDDLNSKVFFSDSSSKGSATWPEEKLPPTRKQSRSNSTSSHYDTL 
               
               
                   
                   
                 KTHLGNTIQGQSGASAAVAWGLVIVTAGHGGEIRSFQNYGLPVRL 
               
               
                   
               
               
                 507 
                 WD40 repeat 
                 MPSIPAIGEFTVCEINRELLTTKDESDTQAKDAYAKILGLVFPPISFQIEEGFG 
                 107 
                 1498 
               
               
                   
                 protein 
                 SASRQQFDQDLDREDTIVTPSTSEGTNALQEGGLLLKGVSVLKNILASSFGPIF 
               
               
                   
                   
                 SPNDTKVLKKVELLQGISWHRHKHILAFISGSNQVTVHDFQDPEWRESSLLVSE 
               
               
                   
                   
                 SQRGIEALEWRPNGGTTLSVACRGGICIWSASYPGSVAPVRSGVASFLGTSTRG 
               
               
                   
                   
                 SSVRWTLVDFLQIPGGKAVTALSWSPTGRLLASASREDSSFTIWDVAQGVGTPL 
               
               
                   
                   
                 RRGLGGISLLKWSPTGDYLFSAKPNGTFYLWETNTWTLEQWSSSGGCVISATWG 
               
               
                   
                   
                 PDGRMLFMAFSESTTLGSLHFAGRPPSLDAHLLPMELPEIGSITGGFGNIEKMA 
               
               
                   
                   
                 WDGCGERLAVSYTGGDLMYVGLIAIYDTRRTPFISASLVGFIRGPGEQVKPLAF 
               
               
                   
                   
                 AFHDKFKQGPLLSVCWSSGLCCTYPLIFRAH 
               
               
                   
               
               
                 508 
                 WD40 repeat 
                 MEEENAKHTEETRQVQVRFTTKLQPALRVPTTSIAIPAHLTRYGLSDIVNTLLG 
                 118 
                 1425 
               
               
                   
                 protein 
                 NDKPQPFDFLVESELVRTSLEKLLLIKGISAEKILNIEYILAVVPPKQEEPSLH 
               
               
                   
                   
                 DDWVSVVDGSYPNFIFSGSFDSIGRIWKGEGLCTHVLEGHRDAITSAAFIMPSD 
               
               
                   
                   
                 SSDSFINLATASKDRTLRLWQFKPNEHMTNGKMVRPYKLLKGHTSSVQTVSACP 
               
               
                   
                   
                 RRNLICSGSWDCSIKIWQTAGEMDIESNAGSVKKRKLEDSTEQIISQIEASRTL 
               
               
                   
                   
                 EGHSQCVSSVVWLEKDTIYSASWDHSVRSWDVETGVNSLTVGCRKALHCLSIGG 
               
               
                   
                   
                 EGSALIAAGGADSVLRIWDPRMPGTFTPILQLSSHKSWITACKWHPKSRHHLIS 
               
               
                   
                   
                 ASHDGTLKLWDVRSKVPLTTLEAHKDKVLCADWWKEDCVISGGADSTLQIFSNL 
               
               
                   
                   
                 NLT 
               
               
                   
               
               
                 509 
                 WD40 repeat 
                 MNRLRSKRNHILELRLGQSEPEKEATLASNRSRGTNAPIVVEDDDDVVVSSPRS 
                 186 
                 797 
               
               
                   
                 protein 
                 FALARSSVSQRSSRIPIVNEEDLELRLGLAVTGRTSAEHNPRRRHGRVPPNKPI 
               
               
                   
                   
                 VLCDDAGEADQSSSKKRRTGQQLSSDVQSDESKEVKLTCAICISTMEEETSTIC 
               
               
                   
                   
                 GHIFCKKCITNAIHRWKRCPTCRKKLAINNIHRIYISSSTG 
               
               
                   
               
               
                 510 
                 WD40 repeat 
                 MEEPPPPAVLPSSEDTSIVSSHSFVNAPPTVPVGLDASIPQISTPGINQPGLTI 
                 387 
                 2456 
               
               
                   
                 protein 
                 PVPPEAAPLTASLVAASAGMPPAVVPSFVRPAIVAHPSVMPPPSMPLAALPMPV 
               
               
                   
                   
                 ASAVPVAAPHFPPSTPNDNSITPSMPVPTPIVASSSVPPSVTIPGIAPLPFIAP 
               
               
                   
                   
                 IPVPSSRPVAPSPFMPPARPLGASVSVAMDVDNTDEQDQDADNKGESPSSSPDH 
               
               
                   
                   
                 PEDPSAAEYEITEESRKVRERQEQAIQELLLRRRAYALAVPTNDSSVRARLRRL 
               
               
                   
                   
                 NEPITLFGEREMERRDRLRALMAKLDAEGQLEKLMKVQEEEEAAANVDAEEVQE 
               
               
                   
                   
                 MEGPQVYPFYTEGSQELLKARTEITKFSLPRAVSRLQRARRKREDPDEDEDEEL 
               
               
                   
                   
                 KCVLQQSAQINMDCSEIGDDRPLSGCAFSSDGTLLATSAWSGVTKLWSVPNINK 
               
               
                   
                   
                 VATLKGHTERVTDVAFSPTNCHLATACADRTAMLWNSEGVLMKTYEGHLDRLAR 
               
               
                   
                   
                 LAFHPSGLYLGTASFDKTWRLWDVNTGIELLLQEGHSRSVYGIAFQCDGSLAAT 
               
               
                   
                   
                 CGLDGLARIWDLRTGRSILALEGHVKPVLGIDFSPNGYHLATGSEDHTCRIWDL 
               
               
                   
                   
                 RKRQSVYIIPAHSHLVSQVKFEPQEGYFLVTASYDSTAKVWSARDFKSIKVLAG 
               
               
                   
                   
                 HEAKVTSVDITADGQYIATVSHDRTIKLWSSKNSTNDMNIG 
               
               
                   
               
               
                 511 
                 WD40 repeat 
                 MKRAYKLQEFVAHASNVNCLKIGKKSSRVLVTGGEDHKVNMWAIGKPNAILSLS 
                 359 
                 2761 
               
               
                   
                 protein 
                 GHSSAVESVTFDSAEALVVAGAASGTIKLWDLEEAKIVRTLTGHRSNCISVDFH 
               
               
                   
                   
                 PFGEFFASGSLDTNLKIWDIRRKGCIHTYKGHTRGVNSIRFSPDGRWVVSGGED 
               
               
                   
                   
                 NIVKLWDLTAGKLMHDFKCHEGQIQCMDFHPQEFLLATGSADRTVKFWDLETFE 
               
               
                   
                   
                 LIGSAGPETTGVRAMIFNPDGRTLLTGLHESLKVFSWEPLRCYDAVDVGWSKLA 
               
               
                   
                   
                 DLNIHEGKLLGCSYNQSCVGVWVVDISRVGPYAAGNVSRTNGHNEAKLASSGHP 
               
               
                   
                   
                 SVQQLDNNLKTNMARLSLSHSTESGIKEPKTTTSLTTTEGLSSTPQRAGIAFSS 
               
               
                   
                   
                 KNLPASSGPPSYVSTPKKNSTSRVQPTTNFQTLSRPDIVPVIVPRSNSLRPETT 
               
               
                   
                   
                 SDAKKEMNNFGRVVPSTVSTKSTDVIKSGSNRDESDKIDSINQKRMTGNDKTDL 
               
               
                   
                   
                 NIARAEQHVSSRLDNTNTSSVVCDGNQPAARWIGAAKFRRNSPVDPVVSPHDRS 
               
               
                   
                   
                 PTFPWSATDDGVTCQPDRQVTAPELSKRVVEPGRARALVASWETREKALTADTP 
               
               
                   
                   
                 VLVSGRPPTSPGVDMNSFIPRGSHGTSESDLTVSDDNSAIEELMQQHNAFTSIL 
               
               
                   
                   
                 QARLTKLQVIRRFWQRNDLKGAIDATGKMGDHSVSADVISVLIERSEIFTLDIC 
               
               
                   
                   
                 TVILPLLTRLLQSETDRHLTVAMETLLVLVKTFGDVIRATISATPTIGVDLQAE 
               
               
                   
                   
                 QRLERCNLCYVELENIKQILVPLIRRGGAVAKSAQELSLALQEV 
               
               
                   
               
               
                 512 
                 Cyclin B 
                 MAGSDENNPGVVGGAHVQEGLRVGAGKMGAGNVQQRRALSNINSNIIGAPPYPC 
                 238 
                 1648 
               
               
                   
                   
                 AVNKRVLSEKNVNSENDLLNAAHRPITRQFAAQMAYKQQLRPEENKRTTQSVSN 
               
               
                   
                   
                 PSKSEDCAILDVDDDKMADDFPVPMFVQHTEAMLEEIDRMEEVEMEDVAEEPVT 
               
               
                   
                   
                 DIDSGDKENQLAVVEYIDDLYMFYQKAEASSCVPPNYMDRQQDINERMRGILID 
               
               
                   
                   
                 WLIEVHYKFELMDETLYLTVNLIDRFLAVQPVVKKKLQLVGVTAMLLACKYEEV 
               
               
                   
                   
                 SVPVVEDLILISDRAYSRKEVLEMERLMVNTLHFNMSVPTPYVFMRRFLKAAQS 
               
               
                   
                   
                 DKKLELLSFFIIELSLVEYDMLKFPPSLLAASAIYTALSTITRTKQWSTTCEWH 
               
               
                   
                   
                 TSYSEEQLLECARLMVTFHQRAGSGKLTGVHRKYSTSKFGHAARTEPANFLLDF 
               
               
                   
                   
                 RL 
               
               
                   
               
               
                 513 
                 Cyclin- 
                 MQAPREGKSAAAIVGMGKYMKKSKAIPRDVSLLEASPRSPSATGVRTRAKTLAS 
                 59 
                 859 
               
               
                   
                 dependant 
                 RRLRRASQRRPPPPAAAAAAAAPSLDASPCPFSYLQLRSRRLRRPRLAPSPEAR 
               
               
                   
                 kinase 
                 IDEGPAGSGSRGSRDASCSARTASSSGGVEGEGACVGRGDRGNGGECVRDAAVD 
               
               
                   
                 inhibitor 
                 ASYGENDLEIEDRDRSTRESTPCSLIRDSNANTPPGSTTRQQSSCTAHRTQMSI 
               
               
                   
                   
                 LRSIPTSDEMEEFFAYAEQRQQRSFIEKYNFDIVKDRPLPGRFEWVQVIP 
               
               
                   
               
               
                 514 
                 Histone 
                 MDGHSSHLAAQNRSRGSQTPSPSHSAASASATSSIHLKRKLSAANASAASAAAA 
                 44 
                 1829 
               
               
                   
                 acetyltransferase 
                 AAAAAAAADDHAPPFPPSSISADTRDGALTSNDDLESISARGGGAGDDSDDDSD 
               
               
                   
                   
                 DEEEDDGDNDGGSSLRTFTAARLENVGPAAARNRKIKAESNATVKVEKEDSAKD 
               
               
                   
                   
                 GGNGAGVGALGPAATSGAGSGSGTVPKEDAVKIFTENLQASGAYSAREENLKRE 
               
               
                   
                   
                 EEAGRLKFECLSNDGVDDHMVWLIGLKNIFARQLPNMPKEYIVRLVMDRNHKSV 
               
               
                   
                   
                 MVIRRNLVVGGITYRPYASQKFGEIAFCAIKADEQVKGYGTRLMNHLKQHARDV 
               
               
                   
                   
                 DGLTHFLTYADNNAVGYFIKQGFTKEIYLDKDRWHGYIKDYDGGILMECKIDPK 
               
               
                   
                   
                 LPYTDLSTMVRRQRQAIDEKIRELSNCHIVYQGIDFQKRDAGVPQNTIKMEDIP 
               
               
                   
                   
                 GLREAGWTPDQWGYSRFRGLSDQKRLTFFIRQLLKVLNDHSDAWPFKEPVDARE 
               
               
                   
                   
                 VPDYYDIIKDPMDLKTMTKRVESEQYYVTLEMFIADVKRMFANARTYNSPDTIY 
               
               
                   
                   
                 FKIATRLEAHFQSKVQSNLQSGAGKIQQ 
               
               
                   
               
               
                 515 
                 Peptidylprolyl 
                 MFNGMMDPELFKLAQEQMNRMSPAELAKIQQQMMSNPELMRMASESMKNMRPED 
                 109 
                 1866 
               
               
                   
                 isomerase 
                 LRQAAEQLKHVRPEEMAEIGEKMANASPEEIAAVRARADAQMTYEINAAKILKK 
               
               
                   
                   
                 EGNELHSQGRFKDASQKYLRAKNNLKGIPSSEGKNLLLACSLNLMSCYLKTRQY 
               
               
                   
                   
                 EECIKEGSEALACEEKNLKAFYRRGQAYRELGQLKDAVSDLRKAHEISPDDETI 
               
               
                   
                   
                 AQVLRDTEESLTKEGGSAPRGVVIEEITEEDETLASVNHESPSEYSEKRHQESE 
               
               
                   
                   
                 DAHKGPINGDIMGQMTNSESLKALKGDPDAIRSFQNFISNADPTTLAAMGAGNA 
               
               
                   
                   
                 GEVSPDLIKTASSMIGKMSAEELQKMIQLASSFPGENPYVTRNSDSNSNSFGNG 
               
               
                   
                   
                 SIPNVSPDMLKTASDMMSKMSPDDLQRMFEMASSSRGKDPSLDANHASSSSGAN 
               
               
                   
                   
                 LAANLNHILGESEPSSSYHIPSSSRNISSSPLSNFPSSPGDMQEQIRNQMKDPA 
               
               
                   
                   
                 MRQMFTSMMKNMSPEMMANMGKQFGLELSPEDAAKAQEAMSSLSPEMLDKMMRW 
               
               
                   
                   
                 ADRAQRGVETAKKTKNWLLGRPGMILAICMLLLAVILHRLGFIGS 
               
               
                   
               
               
                 516 
                 WD40 repeat 
                 MIAAISWVPRGASKAVPEVAEPPSKEEIEEILKSGVVERSGDSDGEEDDENMDA 
                 212 
                 1815 
               
               
                   
                 protein 
                 VASEKADEVSTALSAADALGRISKVTKAGSGFEDIADGLRELDMDNYDEEDEDV 
               
               
                   
                   
                 KLFSTGLGDLYYPSNDMDPYLKDKDDDDDTEEIEDLSIKPMDSLIVCARTDDEV 
               
               
                   
                   
                 NLLEVYLLEPSLSDESNMYVHHEVVISEFPLCTAWLDCPIKGGDKGNFIAVGSM 
               
               
                   
                   
                 EPAIEIWDLDIIDAVEPCLVLGGQEELKKKKKKGKKASIKYKEGSHTDSVLGLA 
               
               
                   
                   
                 WNKEFRNILASASADRQVKIWDVAAGKCNITMEHHTDKVQAVAWNHHAPQVLLS 
               
               
                   
                   
                 GSFDHSVVMKDGRIPSHSGYRWSVTADVESLAWDPHSEHFFVVSLEDGTVRGFD 
               
               
                   
                   
                 VRAAISNSASQSLPSFTLHAHEKAVSTISYNPAAPNLLATGSTDKMVKLWDLSN 
               
               
                   
                   
                 NQPSCIASRNPKAGAVFSVSFSEDSPLLLAIGGSKGRLEVWDTSSDAAVSRRFG 
               
               
                   
                   
                 KHGKPKTAEPGS 
               
               
                   
               
               
                 517 
                 WD40 repeat 
                 MKFCKKYQEYMQGQEGKKLPGLGFKKLKKILKRCRRRDSLHSQKALQAVQNPRT 
                 207 
                 1193 
               
               
                   
                 protein 
                 CPAHCSVCDGSFFPSLLEEMSAVLGCFNKQAQKLLELHLASGFQKYLMWFKGKL 
               
               
                   
                   
                 RGNHVALIQEGKDLVTYALINAIAIRKILKKYDKIHLSTQGQAFKSQVQRMHME 
               
               
                   
                   
                 ILQSPWLCELIAFHINVRETKANSGKGHALFEGCSLVVDDGKPSLSCELFDSIK 
               
               
                   
                   
                 LDIDLTCSICLDTVFDSVSLTCGHIYCYMCACSAASVTIVDGLKAAEPKEKCPL 
               
               
                   
                   
                 CREARVFEGAVHLDELNILLSRSCPEYWAERLQTERVERVRQAKEHWESQCRAF 
               
               
                   
                   
                 MGVE 
               
               
                   
               
               
                 518 
                 WD40 repeat 
                 MVSTQSTRENPSIFFPPPLKPWLLPVVLSLSLSRQLGMAAAAAASLPFKKNYRS 
                 6 
                 2786 
               
               
                   
                 protein 
                 SQALQQFYAGGPFAVSSDGSFIACNCGDSIKIVDSSNASLRPSIDCGSDTITAL 
               
               
                   
                   
                 SLSPDGKLLFSAGHSRQIRVWDLSTSTCLRSWKGHDGPVMSMACPVSGGLLATG 
               
               
                   
                   
                 GADRKVMVWDVDGGFCTHFFKGHDGVVSTVLFHPDSNRSLLFSGSDDGTIRVWD 
               
               
                   
                   
                 LLAKKCASTLRGHDSTVTSLAFSEDGLTLLAAGRDKVVSLWDLHNYACKKTIPM 
               
               
                   
                   
                 YEVLESVCVIHSGTVLASQLGLDDQLKVTKESAQNIHFITVGERGILRIWKSEG 
               
               
                   
                   
                 SVCLFKQEHSDVTVISDEDDSRSGFTAAVMLPLDQGLLCVTADQQFLFYYPEKH 
               
               
                   
                   
                 PEGIFSLTLCRRLVGYNEEIVDMKFLGEEENFLAVATNLEQVRVYELASMSCSY 
               
               
                   
                   
                 VLAGHTETVLCLDTCISSSGRTLIVTGSKDNSVRLWDSESRHCIGVGVGHMGAV 
               
               
                   
                   
                 GAVAFSRKRQDFFVSGSSDRTLKVWSLDGISEDGVDSTNLKAKAVVAAHDKDIN 
               
               
                   
                   
                 SVAVAPNDSLVCSGSQDRTACVWRLPDLVSVVVLKGHKRGIWSVEFSPVDQCVL 
               
               
                   
                   
                 TASGDKTVKIWAISDGSCLKTFEGHVSSVLRASFLTRGTQFVSCGADGLVKLWT 
               
               
                   
                   
                 VRTNECIATYDQHSDKVWALAVGKKTEMLATGGSDAVVNLWYDSTASDKEDAFR 
               
               
                   
                   
                 KEEEGVLKGQELENAVSDADYTKAIELALELRRPHKLFELFSELCRTREVGDRV 
               
               
                   
                   
                 ERILSALSGEEVCLLLEYIREWNAKPKLCHVAQSVLSQVFRILSPTEIVEIKGI 
               
               
                   
                   
                 GELLEGLIPYSQRHFSRIDRLVRSTYLLDYTLTGMSVIEPEADRSAVNDGSPDK 
               
               
                   
                   
                 SGLEKLEDGLLGENVGEEKIQNKEELESSAYKKRKLPRSKDRSKKKSKNVVYAD 
               
               
                   
                   
                 AAAISFRA 
               
               
                   
               
               
                 519 
                 WD40 repeat 
                 MDSAPRRKSGGINLPSGMSETSLRLDGFSGSSSSFRAISNLTSPSKSSSISDRF 
                 213 
                 1726 
               
               
                   
                 protein 
                 IPCRSSSRLHTFGLVERGSPVKEGGNEAYSRLLKAELFGSDFGSLSPAGQGSPM 
               
               
                   
                   
                 SPSKNMLRFKTESSGPNSPFSPSILRQDSGFSSEASTPPKPPRKVPKTPHKVLD 
               
               
                   
                   
                 APSLQDDFYLNLVDWSSQNTLAVGLGTCVYLWSASNSKVTKLCDLGPNDGVCAV 
               
               
                   
                   
                 QWTREGSYISIGTSLGQVQIWDGTQCKRVRTMGGHQTRTGVLAWNSRILASGSR 
               
               
                   
                   
                 DRVILQHDLRVPNEFIGKLVGHKSEVCGLKWSHDDRELASGGNDNQLLVWNQHS 
               
               
                   
                   
                 QQPVLKLTEHTAAVKAIAWSPHQNGLLASGGGTADRCIRFWNTTNGHQTSSVDT 
               
               
                   
                   
                 GSQVCNLAWSKNVNELVSTHGYSQNQIMVWKYPSMAKVATLTGHSLRVLYLAMS 
               
               
                   
                   
                 PDGQTIVTGAGDETLRFWNVFPSAKAPAPVKDTGLWSLGRTHIR 
               
               
                   
               
               
                 520 
                 WD40 repeat 
                 MEDEAEIYDGVRAQFPLTFGKQSKPQTSLESVHSATRRGGPAPAPAPASSSSLP 
                 101 
                 2110 
               
               
                   
                 protein 
                 STTSPSAAGGAGKSSGLPSLSSSSTAWLEGLRAGNPRAGREAGIGSRGGDGEDG 
               
               
                   
                   
                 GRAMIGPPRPPPGFSANDDGGGEDDDDDGDGVMVGPPPPPPGNLGDGDDDEEEE 
               
               
                   
                   
                 EAMIGPPRPPVVDSDEEEEEEEEENRYRLPLSNEIVLKGHNKIVSALAVDPTGS 
               
               
                   
                   
                 RVLSGSYDYTVRMFDFQSMNSRLSSFRDFEPVEGHQVRNLSWSPTADRFLCVTG 
               
               
                   
                   
                 SAQAKIYDRDGLTLGEFVKGDMYIRDLKNTKGHITGLTWGEWHPKTKETILTSS 
               
               
                   
                   
                 EDGSLRIWDVNDFKSQKQVIKPKLARPGRVPVTTCTWDREGKCIAGGIGDGSIQ 
               
               
                   
                   
                 IWNLKPGWGSRPDIHVEQAHADDITGLKFSSDGKILLTRSFDDSLKVWDLRLMK 
               
               
                   
                   
                 NPLKVFEDLPNHYAQTNIACSPDEQLFLTGTSVERESTIGGLLCFFDRSKLELV 
               
               
                   
                   
                 SRIGISPTCSVVQCAWHPRLNQIFATSGDKSQGGTHVLYDPTLSERGALVCVAR 
               
               
                   
                   
                 APRKKSVDDFELKPVIHNPHALPLFRDQPSRKRQREKILKDPLKSHKPELPMNG 
               
               
                   
                   
                 PGHGGRVGASKGSLLTQYLLKQGGMIKETWMDEDPREAILKHADAAEKNPKFTR 
               
               
                   
                   
                 AYAETQPDPVFAKSDSEDEDK 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 16 
               
             
            
               
                   
               
               
                 BLAST Sequence Alignment Table. 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                 BlastX top 
                   
                 BlastX e 
                 BlastX 
                 BlastX 
               
               
                 SEQ ID 
                 Target 
                 Patent Identifier 
                 hit 
                 Gene name 
                 value 
                 identities 
                 overlap 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 1 
                 CDK type A 
                 eucalyptusSpp_003910 
                 Q9FRN5 
                 PUTATIVE 
                 0 
                 367 
                 492 
               
               
                   
                   
                   
                   
                 SERINE/THREONINE 
               
               
                   
                   
                   
                   
                 KINASE 
               
               
                 2 
                 CDK type A 
                 eucalyptusSpp_019213 
                 O44000 
                 CDC2-LIKE 
                 e−160 
                 217 
                 290 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                   
                   
                   
                   
                 KINASE TPK2 
               
               
                 3 
                 CDK type A 
                 eucalyptusSpp_036800 
                 Q40789 
                 PROTEIN 
                 0 
                 259 
                 294 
               
               
                   
                   
                   
                   
                 KINASE 
               
               
                   
                   
                   
                   
                 P34CDC2 
               
               
                 4 
                 CDK type A 
                 eucalyptusSpp_040260 
                 Q27168 
                 CDC2 
                 e−156 
                 208 
                 304 
               
               
                 5 
                 CDK type A 
                 eucalyptusSpp_041965 
                 Q43361 
                 CDC2PA mRNA. 
                 e−159 
                 274 
                 294 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 6 
                 CDK type B-1 
                 eucalyptusSpp_002906 
                 Q9FYT9 
                 Cyclin- 
                 e−159 
                 269 
                 305 
               
               
                   
                   
                   
                   
                 dependent 
               
               
                   
                   
                   
                   
                 kinase B1-1 
               
               
                 7 
                 CDK type B-2 
                 eucalyptusSpp_001518 
                 Q9FSH4 
                 B2-TYPE 
                 0 
                 270 
                 315 
               
               
                   
                   
                   
                   
                 CYCLIN 
               
               
                   
                   
                   
                   
                 DEPENDENT 
               
               
                   
                   
                   
                   
                 KINASE 
               
               
                 8 
                 CDK type C 
                 eucalyptusSpp_008078 
                 Q9LDC1 
                 CRK1 protein 
                 0 
                 415 
                 558 
               
               
                 9 
                 CDK type C 
                 eucalyptusSpp_009826 
                 Q9LNN0 
                 F8L10.9 
                 0 
                 392 
                 716 
               
               
                   
                   
                   
                   
                 protein. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 10 
                 CDK type C 
                 eucalyptusSpp_010364 
                 Q8GZA7 
                 Putative 
                 e−172 
                 309 
                 499 
               
               
                   
                   
                   
                   
                 cyclin- 
               
               
                   
                   
                   
                   
                 dependent 
               
               
                   
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                   
                 kinase. 
               
               
                 11 
                 CDK type C 
                 eucalyptusSpp_011523 
                 Q8W2N0 
                 Cyclin- 
                 e−165 
                 273 
                 405 
               
               
                   
                   
                   
                   
                 dependent 
               
               
                   
                   
                   
                   
                 kinase CDC2C 
               
               
                 12 
                 CDK type C 
                 eucalyptusSpp_024358 
                 P93320 
                 CDC2MSC 
                 0 
                 448 
                 523 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 13 
                 CDK type C 
                 eucalyptusSpp_039125 
                 O80540 
                 F14J9.26 
                 0 
                 418 
                 743 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 14 
                 CDK type D 
                 eucalyptusSpp_005362 
                 O80345 
                 CDK- 
                 e−180 
                 305 
                 483 
               
               
                   
                   
                   
                   
                 activating 
               
               
                   
                   
                   
                   
                 kinase 1AT 
               
               
                   
                   
                   
                   
                 (Cdk- 
               
               
                   
                   
                   
                   
                 activating 
               
               
                   
                   
                   
                   
                 kinase 
               
               
                   
                   
                   
                   
                 CAK1At) 
               
               
                 15 
                 CDK type D 
                 eucalyptusSpp_044857 
                 O80345 
                 CDK- 
                 e−177 
                 302 
                 477 
               
               
                   
                   
                   
                   
                 activating 
               
               
                   
                   
                   
                   
                 kinase 1AT 
               
               
                   
                   
                   
                   
                 (Cdk- 
               
               
                   
                   
                   
                   
                 activating 
               
               
                   
                   
                   
                   
                 kinase 
               
               
                   
                   
                   
                   
                 CAK1At) 
               
               
                 16 
                 Cyclin A 
                 eucalyptusSpp_001743 
                 Q39879 
                 MITOTIC 
                 0 
                 360 
                 508 
               
               
                   
                   
                   
                   
                 CYCLIN A2- 
               
               
                   
                   
                   
                   
                 TYPE 
               
               
                 17 
                 Cyclin A 
                 eucalyptusSpp_012405 
                 Q39878 
                 MITOTIC 
                 e−179 
                 278 
                 470 
               
               
                   
                   
                   
                   
                 CYCLIN A2- 
               
               
                   
                   
                   
                   
                 TYPE 
               
               
                 18 
                 Cyclin B 
                 eucalyptusSpp_003739 
                 Q9LDM4 
                 F2D10.10 
                 e−148 
                 288 
                 466 
               
               
                   
                   
                   
                   
                 (F5M15.6) 
               
               
                 19 
                 Cyclin B 
                 eucalyptusSpp_022338 
                 P93557 
                 Mitotic 
                 e−168 
                 310 
                 476 
               
               
                   
                   
                   
                   
                 cyclin 
               
               
                 20 
                 Cyclin B 
                 eucalyptusSpp_028605 
                 Q40337 
                 B-like 
                 e−158 
                 300 
                 439 
               
               
                   
                   
                   
                   
                 cyclin. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 21 
                 Cyclin B 
                 eucalyptusSpp_041006 
                 Q40337 
                 B-like 
                 e−158 
                 300 
                 439 
               
               
                   
                   
                   
                   
                 cyclin 
               
               
                 22 
                 Cyclin D 
                 eucalyptusSpp_006643 
                 Q9SXN7 
                 NtcycD3-1 
                 1E−73 
                 177 
                 404 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 23 
                 Cyclin D 
                 eucalyptusSpp_045338 
                 Q8LK74 
                 Cyclin D3.1 
                 e−101 
                 190 
                 332 
               
               
                   
                   
                   
                   
                 protein. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 24 
                 Cyclin D 
                 eucalyptusSpp_046486 
                 Q9ZRX7 
                 CYCLIN D3.2 
                 e−126 
                 196 
                 373 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 25 
                 Cyclin- 
                 eucalyptusSpp_012070 
                 CAB69358 
                 SEQUENCE 1 
                 8E−64 
                 83 
                 88 
               
               
                   
                 dependent 
                   
                   
                 FROM PATENT 
               
               
                   
                 kinase 
                   
                   
                 WO9841642 
               
               
                   
                 regulatory 
               
               
                   
                 subunit 
               
               
                 26 
                 Histone 
                 eucalyptusSpp_006617 
                 O80378 
                 181 
                 0 
                 371 
                 395 
               
               
                   
                 acetyltransferase 
                   
                   
                 (Fragment) 
               
               
                 27 
                 Histone 
                 eucalyptusSpp_007827 
                 Q9FJT8 
                 Histone 
                 e−148 
                 260 
                 465 
               
               
                   
                 acetyltransferase 
                   
                   
                 acetyltransferase 
               
               
                   
                   
                   
                   
                 HAT B 
               
               
                 28 
                 Histone 
                 eucalyptusSpp_008036 
                 Q9FJT8 
                 Histone 
                 e−149 
                 262 
                 465 
               
               
                   
                 acetyltransferase 
                   
                   
                 acetyltransferase 
               
               
                   
                   
                   
                   
                 HAT B. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 30 
                 Histone 
                 eucalyptusSpp_001596 
                 Q9M4T5 
                 Putative 
                 7E−76 
                 156 
                 305 
               
               
                   
                 deacetylase 
                   
                   
                 histone 
               
               
                   
                   
                   
                   
                 deacetylase 
               
               
                   
                   
                   
                   
                 HD2 
               
               
                 31 
                 Histone 
                 eucalyptusSpp_005870 
                 Q9M4T4 
                 Putative 
                 7E−66 
                 144 
                 318 
               
               
                   
                 deacetylase 
                   
                   
                 histone 
               
               
                   
                   
                   
                   
                 deacetylase 
               
               
                   
                   
                   
                   
                 HD2c 
               
               
                   
                   
                   
                   
                 (AT5g03740/F17C15_160) 
               
               
                 32 
                 Histone 
                 eucalyptusSpp_006901 
                 HDAC_ARATH 
                 Histone 
                 0 
                 405 
                 499 
               
               
                   
                 deacetylase 
                   
                   
                 deacetylase 
               
               
                   
                   
                   
                   
                 (HD) 
               
               
                 33 
                 Histone 
                 eucalyptusSpp_006902 
                 AAM13152 
                 HISTONE 
                 0 
                 427 
                 499 
               
               
                   
                 deacetylase 
                   
                   
                 DEACETYLASE 
               
               
                 34 
                 Histone 
                 eucalyptusSpp_007440 
                 Q8W508 
                 HISTONE 
                 0 
                 369 
                 428 
               
               
                   
                 deacetylase 
                   
                   
                 DEACETYLASE 
               
               
                 35 
                 Histone 
                 eucalyptusSpp_008994 
                 Q8LD93 
                 Histone 
                 0 
                 354 
                 536 
               
               
                   
                 deacetylase 
                   
                   
                 deacetylase, 
               
               
                   
                   
                   
                   
                 putative 
               
               
                 36 
                 Histone 
                 eucalyptusSpp_024580 
                 Q94EJ2 
                 At1g08460/T27G7_7 
                 e−165 
                 274 
                 373 
               
               
                   
                 deacetylase 
                   
                   
                 (HDA8). 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 37 
                 Histone 
                 eucalyptusSpp_037831 
                 Q9FML2 
                 Histone 
                 0 
                 356 
                 464 
               
               
                   
                 deacetylase 
                   
                   
                 deacetylase. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 38 
                 MAT1 CDK- 
                 eucalyptusSpp_034958 
                 Q8LES8 
                 Hypothetical 
                 4E−47 
                 101 
                 190 
               
               
                   
                 activating 
                   
                   
                 protein 
               
               
                   
                 kinase 
               
               
                   
                 assembly 
               
               
                   
                 factor 
               
               
                 39 
                 Peptidylprolyl 
                 001209EGXC004488HT 
                 TL40_SPIOL 
                 Peptidylprolyl 
                 0 
                 329 
                 392 
               
               
                   
                 isomerase 
                   
                   
                 cis- 
               
               
                   
                   
                   
                   
                 trans 
               
               
                   
                   
                   
                   
                 isomerase, 
               
               
                   
                   
                   
                   
                 chloroplast 
               
               
                   
                   
                   
                   
                 precursor 
               
               
                 40 
                 Peptidylprolyl 
                 010310EGXD012820HT 
                 Q9FJL3 
                 PEPTIDYLPROLYL 
                 0 
                 453 
                 579 
               
               
                   
                 isomerase 
                   
                   
                 ISOMERASE 
               
               
                 41 
                 Peptidylprolyl 
                 010310EGXD013036HT 
                 O82646 
                 HYPOTHETICAL 
                 0 
                 302 
                 521 
               
               
                   
                 isomerase 
                   
                   
                 57.1 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN (EC 
               
               
                   
                   
                   
                   
                 5.2.1.8) 
               
               
                 42 
                 Peptidylprolyl 
                 010316EGXF999037HT 
                 BAB39983 
                 PUTATIVE 
                 e−115 
                 146 
                 172 
               
               
                   
                 isomerase 
                   
                   
                 PEPTIDYLPROLYL 
               
               
                   
                   
                   
                   
                 CIS- 
               
               
                   
                   
                   
                   
                 TRANS 
               
               
                   
                   
                   
                   
                 ISOMERASE, 
               
               
                   
                   
                   
                   
                 CHLOROPLAST 
               
               
                 43 
                 Peptidylprolyl 
                 010324EGXF002118HT 
                 AAK32894 
                 AT5G13120/T19L5_80 
                 e−122 
                 179 
                 264 
               
               
                   
                 isomerase 
               
               
                 44 
                 Peptidylprolyl 
                 011019EGKA001923HT 
                 AAM14253 
                 HYPOTHETICAL 
                 e−108 
                 146 
                 188 
               
               
                   
                 isomerase 
                   
                   
                 20.3 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 45 
                 Peptidylprolyl 
                 eucalyptusSpp_000966 
                 Q8L5T1 
                 Peptidylprolyl 
                 1E−91 
                 155 
                 170 
               
               
                   
                 isomerase 
                   
                   
                 isomerase 
               
               
                   
                   
                   
                   
                 (Cyclophilin) 
               
               
                   
                   
                   
                   
                 (EC 
               
               
                   
                   
                   
                   
                 5.2.1.8) 
               
               
                 46 
                 Peptidylprolyl 
                 eucalyptusSpp_001037 
                 Q8VX73 
                 CYCLOPHILIN 
                 e−120 
                 155 
                 169 
               
               
                   
                 isomerase 
                   
                   
                 (EC 5.2.1.8) 
               
               
                 47 
                 Peptidylprolyl 
                 eucalyptusSpp_004603 
                 AAM14253 
                 HYPOTHETICAL 
                 e−108 
                 146 
                 188 
               
               
                   
                 isomerase 
                   
                   
                 20.3 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN. 
               
               
                 48 
                 Peptidylprolyl 
                 eucalyptusSpp_005465 
                 Q9SP02 
                 Cyclophilin 
                 2E−93 
                 172 
                 204 
               
               
                   
                 isomerase 
                   
                   
                 ROC7 (EC 
               
               
                   
                   
                   
                   
                 5.2.1.8) 
               
               
                   
                   
                   
                   
                 (AT5g58710/mzn1_160) 
               
               
                   
                   
                   
                   
                 (Pepti . . . 
               
               
                 49 
                 Peptidylprolyl 
                 eucalyptusSpp_006571 
                 O49605 
                 EC 5.2.1.8 
                 9E−98 
                 169 
                 224 
               
               
                   
                 isomerase 
                   
                   
                 (Cyclophilin- 
               
               
                   
                   
                   
                   
                 like 
               
               
                   
                   
                   
                   
                 protein) 
               
               
                   
                   
                   
                   
                 (Peptidyl- 
               
               
                   
                   
                   
                   
                 prolyl 
               
               
                 50 
                 Peptidylprolyl 
                 eucalyptusSpp_006786 
                 Q93VG0 
                 Cyclophilin 
                 5E−82 
                 142 
                 164 
               
               
                   
                 isomerase 
                   
                   
                 (EC 5.2.1.8) 
               
               
                   
                   
                   
                   
                 (Peptidyl- 
               
               
                   
                   
                   
                   
                 prolyl cis- 
               
               
                   
                   
                   
                   
                 trans 
               
               
                 51 
                 Peptidylprolyl 
                 eucalyptusSpp_007057 
                 Q38901 
                 Cytosolic 
                 3E−84 
                 144 
                 172 
               
               
                   
                 isomerase 
                   
                   
                 cyclophilin 
               
               
                   
                   
                   
                   
                 (EC 5.2.1.8) 
               
               
                   
                   
                   
                   
                 (Peptidyl- 
               
               
                   
                   
                   
                   
                 prolyl 
               
               
                 52 
                 Peptidylprolyl 
                 eucalyptusSpp_008670 
                 Q9FJL3 
                 PEPTIDYLPROLYL 
                 0 
                 423 
                 596 
               
               
                   
                 isomerase 
                   
                   
                 ISOMERASE 
               
               
                 53 
                 Peptidylprolyl 
                 eucalyptusSpp_009137 
                 Q9C566 
                 Cyclophilin- 
                 e−168 
                 285 
                 361 
               
               
                   
                 isomerase 
                   
                   
                 40 (EC 
               
               
                   
                   
                   
                   
                 5.2.1.8) 
               
               
                   
                   
                   
                   
                 (Expressed 
               
               
                   
                   
                   
                   
                 protein) 
               
               
                 54 
                 Peptidylprolyl 
                 eucalyptusSpp_010285 
                 Q9LY75 
                 Cyclophylin- 
                 e−160 
                 345 
                 658 
               
               
                   
                 isomerase 
                   
                   
                 like protein 
               
               
                   
                   
                   
                   
                 (EC 5.2.1.8) 
               
               
                   
                   
                   
                   
                 (Peptidyl- 
               
               
                   
                   
                   
                   
                 prolyl 
               
               
                 55 
                 Peptidylprolyl 
                 eucalyptusSpp_010600 
                 Q93YQ8 
                 HYPOTHETICAL 
                 0 
                 346 
                 475 
               
               
                   
                 isomerase 
                   
                   
                 50.1 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                   
                   
                   
                   
                 (FRAGMENT) 
               
               
                 56 
                 Peptidylprolyl 
                 eucalyptusSpp_011551 
                 Q9ZVG4 
                 T2P11.13 
                 e−115 
                 154 
                 192 
               
               
                   
                 isomerase 
                   
                   
                 PROTEIN 
               
               
                 57 
                 Peptidylprolyl 
                 eucalyptusSpp_020743 
                 Q8VXA5 
                 PUTATIVE 
                 e−125 
                 161 
                 172 
               
               
                   
                 isomerase 
                   
                   
                 CYCLOSPORIN 
               
               
                   
                   
                   
                   
                 A-BINDING 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 58 
                 Peptidylprolyl 
                 eucalyptusSpp_023739 
                 FK21_NEUCR 
                 FK506- 
                 3E−49 
                 74 
                 112 
               
               
                   
                 isomerase 
                   
                   
                 binding 
               
               
                   
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                   
                 precursor 
               
               
                   
                   
                   
                   
                 (FKBP-21) 
               
               
                 60 
                 Peptidylprolyl 
                 eucalyptusSpp_031985 
                 Q8L8W5 
                 Cyclophilin- 
                 1E−82 
                 155 
                 229 
               
               
                   
                 isomerase 
                   
                   
                 like protein 
               
               
                   
                   
                   
                   
                 (EC 5.2.1.8) 
               
               
                   
                   
                   
                   
                 (Peptidyl- 
               
               
                   
                   
                   
                   
                 prolyl 
               
               
                 61 
                 Peptidylprolyl 
                 eucalyptusSpp_032025 
                 Q9LPC7 
                 F22M8.7 
                 1E−45 
                 99 
                 160 
               
               
                   
                 isomerase 
                   
                   
                 protein (EC 
               
               
                   
                   
                   
                   
                 5.2.1.8) 
               
               
                   
                   
                   
                   
                 (Peptidyl- 
               
               
                   
                   
                   
                   
                 prolyl cis- 
               
               
                   
                   
                   
                   
                 trans 
               
               
                 62 
                 Peptidylprolyl 
                 eucalyptusSpp_032173 
                 Q8L8W5 
                 Cyclophilin- 
                 4E−83 
                 156 
                 229 
               
               
                   
                 isomerase 
                   
                   
                 like protein 
               
               
                   
                   
                   
                   
                 (EC 5.2.1.8) 
               
               
                   
                   
                   
                   
                 (Peptidyl- 
               
               
                   
                   
                   
                   
                 prolyl 
               
               
                 64 
                 Retinoblastoma 
                 eucalyptusSpp_009143 
                 Q9SLZ4 
                 Retinoblastoma- 
                 0 
                 704 
                 1008 
               
               
                   
                 related 
                   
                   
                 related 
               
               
                   
                 protein 
                   
                   
                 protein 
               
               
                 65 
                 WD40 repeat 
                 eucalyptusSpp_000349 
                 AAK49947 
                 TGF-BETA 
                 0 
                 291 
                 326 
               
               
                   
                 protein 
                   
                   
                 RECEPTOR- 
               
               
                   
                   
                   
                   
                 INTERACTING 
               
               
                   
                   
                   
                   
                 PROTEIN 1 
               
               
                 66 
                 WD40 repeat 
                 eucalyptusSpp_000575 
                 Q9LW17 
                 WD-40 repeat 
                 e−168 
                 282 
                 341 
               
               
                   
                 protein 
                   
                   
                 protein-like 
               
               
                   
                   
                   
                   
                 (Expressed 
               
               
                   
                   
                   
                   
                 protein) 
               
               
                 67 
                 WD40 repeat 
                 eucalyptusSpp_000804 
                 GBLP_SOYBN 
                 Guanine 
                 0 
                 291 
                 326 
               
               
                   
                 protein 
                   
                   
                 nucleotide- 
               
               
                   
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                   
                 protein beta 
               
               
                   
                   
                   
                   
                 subunit-like 
               
               
                 68 
                 WD40 repeat 
                 eucalyptusSpp_000805 
                 GBLP_MEDSA 
                 Guanine 
                 e−171 
                 291 
                 327 
               
               
                   
                 protein 
                   
                   
                 nucleotide- 
               
               
                   
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                   
                 protein beta 
               
               
                 69 
                 WD40 repeat 
                 eucalyptusSpp_000806 
                 GBLP_MEDSA 
                 Guanine 
                 e−171 
                 291 
                 327 
               
               
                   
                 protein 
                   
                   
                 nucleotide- 
               
               
                   
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                   
                 protein beta 
               
               
                   
                   
                   
                   
                 subunit-like 
               
               
                 70 
                 WD40 repeat 
                 eucalyptusSpp_002248 
                 AAL86002 
                 HYPOTHETICAL 
                 0 
                 261 
                 388 
               
               
                   
                 protein 
                   
                   
                 43.8 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 71 
                 WD40 repeat 
                 eucalyptusSpp_003203 
                 Q9SY00 
                 Putative WD- 
                 e−144 
                 236 
                 317 
               
               
                   
                 protein 
                   
                   
                 repeat 
               
               
                   
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                   
                 (AT4G02730/T5J8_2) 
               
               
                 72 
                 WD40 repeat 
                 eucalyptusSpp_003209 
                 AAM14986 
                 HYPOTHETICAL 
                 e−160 
                 259 
                 302 
               
               
                   
                 protein 
                   
                   
                 32.6 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 73 
                 WD40 repeat 
                 eucalyptusSpp_004429 
                 Q9SZQ5 
                 HYPOTHETICAL 
                 0 
                 260 
                 322 
               
               
                   
                 protein 
                   
                   
                 34.3 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 74 
                 WD40 repeat 
                 eucalyptusSpp_004607 
                 AAC27402 
                 EXPRESSED 
                 0 
                 253 
                 356 
               
               
                   
                 protein 
                   
                   
                 PROTEIN 
               
               
                 75 
                 WD40 repeat 
                 eucalyptusSpp_004682 
                 AAK00964 
                 HYPOTHETICAL 
                 0 
                 264 
                 313 
               
               
                   
                 protein 
                   
                   
                 35.3 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 76 
                 WD40 repeat 
                 eucalyptusSpp_005786 
                 Q944S2 
                 At2g47790/F17A22.18 
                 e−155 
                 264 
                 396 
               
               
                   
                 protein 
                   
                   
                 (Expressed 
               
               
                   
                   
                   
                   
                 protein). 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 77 
                 WD40 repeat 
                 eucalyptusSpp_005887 
                 Q94AB4 
                 AT3g13340/MDC11_13 
                 0 
                 332 
                 446 
               
               
                   
                 protein 
               
               
                 78 
                 WD40 repeat 
                 eucalyptusSpp_005981 
                 Q8L4X6 
                 WD-repeat 
                 0 
                 315 
                 348 
               
               
                   
                 protein 
                   
                   
                 protein 
               
               
                   
                   
                   
                   
                 GhTTG2. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 79 
                 WD40 repeat 
                 eucalyptusSpp_006766 
                 Q8L4M1 
                 Putative WD- 
                 e−137 
                 234 
                 369 
               
               
                   
                 protein 
                   
                   
                 40 repeat 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 80 
                 WD40 repeat 
                 eucalyptusSpp_006769 
                 Q9LJC6 
                 RETINOBLASTOMA- 
                 0 
                 372 
                 566 
               
               
                   
                 protein 
                   
                   
                 BINDING 
               
               
                   
                   
                   
                   
                 PROTEIN-LIKE 
               
               
                 81 
                 WD40 repeat 
                 eucalyptusSpp_006907 
                 Q94C94 
                 Hypothetical 
                 0 
                 446 
                 812 
               
               
                   
                 protein 
                   
                   
                 protein. 
               
               
                 82 
                 WD40 repeat 
                 eucalyptusSpp_007518 
                 Q93ZN5 
                 AT4G00090/F6N15_8 
                 0 
                 311 
                 436 
               
               
                   
                 protein 
               
               
                 83 
                 WD40 repeat 
                 eucalyptusSpp_007717 
                 O82266 
                 At2g47990 
                 e−180 
                 327 
                 528 
               
               
                   
                 protein 
                   
                   
                 protein 
               
               
                   
                   
                   
                   
                 (Hypothetical 
               
               
                   
                   
                   
                   
                 58.9 kDa 
               
               
                   
                   
                   
                   
                 protein) 
               
               
                 84 
                 WD40 repeat 
                 eucalyptusSpp_007718 
                 Q8RWD8 
                 Hypothetical 
                 e−173 
                 278 
                 350 
               
               
                   
                 protein 
                   
                   
                 protein. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 85 
                 WD40 repeat 
                 eucalyptusSpp_007741 
                 Q8LA40 
                 Putative WD- 
                 e−158 
                 269 
                 409 
               
               
                   
                 protein 
                   
                   
                 40 repeat 
               
               
                   
                   
                   
                   
                 protein, 
               
               
                   
                   
                   
                   
                 MSI2 
               
               
                 86 
                 WD40 repeat 
                 eucalyptusSpp_007884 
                 Q9FHY2 
                 Similarity 
                 e−149 
                 316 
                 765 
               
               
                   
                 protein 
                   
                   
                 to unknown 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 87 
                 WD40 repeat 
                 eucalyptusSpp_008258 
                 Q9LHN3 
                 EMB|CAB63739.1 
                 0 
                 524 
                 758 
               
               
                   
                 protein 
                   
                   
                 (AT3G18860/MCB22_3) 
               
               
                 88 
                 WD40 repeat 
                 eucalyptusSpp_008465 
                 Q9FLS2 
                 WD-repeat 
                 0 
                 366 
                 460 
               
               
                   
                 protein 
                   
                   
                 protein-like 
               
               
                 89 
                 WD40 repeat 
                 eucalyptusSpp_008616 
                 Q9LYK6 
                 Hypothetical 
                 e−148 
                 252 
                 321 
               
               
                   
                 protein 
                   
                   
                 protein 
               
               
                 90 
                 WD40 repeat 
                 eucalyptusSpp_008690 
                 Q9SW94 
                 G PROTEIN 
                 0 
                 326 
                 376 
               
               
                   
                 protein 
                   
                   
                 BETA SUBUNIT 
               
               
                 91 
                 WD40 repeat 
                 eucalyptusSpp_008708 
                 Q8L862 
                 Hypothetical 
                 e−167 
                 297 
                 487 
               
               
                   
                 protein 
                   
                   
                 protein 
               
               
                 92 
                 WD40 repeat 
                 eucalyptusSpp_008850 
                 O22725 
                 F11P17.7 
                 0 
                 402 
                 853 
               
               
                   
                 protein 
                   
                   
                 protein. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 93 
                 WD40 repeat 
                 eucalyptusSpp_009072 
                 Q9SAJ0 
                 F23A5.2 (form 
                 e−176 
                 288 
                 350 
               
               
                   
                 protein 
                   
                   
                 2) (mRNA 
               
               
                   
                   
                   
                   
                 export 
               
               
                   
                   
                   
                   
                 protein, 
               
               
                   
                   
                   
                   
                 putative) 
               
               
                 94 
                 WD40 repeat 
                 eucalyptusSpp_009465 
                 Q9FLX9 
                 NOTCHLESS 
                 0 
                 384 
                 475 
               
               
                   
                 protein 
                   
                   
                 PROTEIN 
               
               
                   
                   
                   
                   
                 HOMOLOG 
               
               
                 95 
                 WD40 repeat 
                 eucalyptusSpp_009472 
                 Q9SZA4 
                 WD-REPEAT 
                 0 
                 374 
                 457 
               
               
                   
                 protein 
                   
                   
                 PROTEIN-LIKE 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 96 
                 WD40 repeat 
                 eucalyptusSpp_009550 
                 Q9FKT5 
                 Gb|AAF54217.1 
                 e−167 
                 275 
                 313 
               
               
                   
                 protein 
                   
                   
                 (Hypothetical 
               
               
                   
                   
                   
                   
                 protein) 
               
               
                 97 
                 WD40 repeat 
                 eucalyptusSpp_010284 
                 O22466 
                 WD-40 repeat 
                 0 
                 397 
                 423 
               
               
                   
                 protein 
                   
                   
                 protein MSI1 
               
               
                 98 
                 WD40 repeat 
                 eucalyptusSpp_010595 
                 Q94C94 
                 Hypothetical 
                 0 
                 419 
                 789 
               
               
                   
                 protein 
                   
                   
                 protein 
               
               
                 99 
                 WD40 repeat 
                 eucalyptusSpp_010657 
                 Q94AH2 
                 HYPOTHETICAL 
                 0 
                 243 
                 298 
               
               
                   
                 protein 
                   
                   
                 33.1 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 100 
                 WD40 repeat 
                 eucalyptusSpp_012636 
                 Q8L611 
                 Hypothetical 
                 0 
                 756 
                 1133 
               
               
                   
                 protein 
                   
                   
                 protein 
               
               
                 101 
                 WD40 repeat 
                 eucalyptusSpp_012748 
                 AAD10151 
                 PUTATIVE WD- 
                 0 
                 375 
                 469 
               
               
                   
                 protein 
                   
                   
                 40 REPEAT 
               
               
                   
                   
                   
                   
                 PROTEIN, 
               
               
                   
                   
                   
                   
                 MSI4 
               
               
                 102 
                 WD40 repeat 
                 eucalyptusSpp_012879 
                 Q8VZY6 
                 FERTILIZATION- 
                 0 
                 291 
                 377 
               
               
                   
                 protein 
                   
                   
                 INDEPENDENT 
               
               
                   
                   
                   
                   
                 ENDOSPERM 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 103 
                 WD40 repeat 
                 eucalyptusSpp_015515 
                 Q8LPI5 
                 Putative WD- 
                 0 
                 360 
                 493 
               
               
                   
                 protein 
                   
                   
                 repeat 
               
               
                   
                   
                   
                   
                 protein. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 104 
                 WD40 repeat 
                 eucalyptusSpp_015724 
                 O22607 
                 WD-40 repeat 
                 0 
                 395 
                 522 
               
               
                   
                 protein 
                   
                   
                 protein MSI4 
               
               
                 105 
                 WD40 repeat 
                 eucalyptusSpp_016167 
                 Q93YS7 
                 Putative WD- 
                 0 
                 663 
                 917 
               
               
                   
                 protein 
                   
                   
                 repeat 
               
               
                   
                   
                   
                   
                 membrane 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 106 
                 WD40 repeat 
                 eucalyptusSpp_016633 
                 Q9SUY6 
                 HYPOTHETICAL 
                 e−174 
                 240 
                 384 
               
               
                   
                 protein 
                   
                   
                 43.8 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 107 
                 WD40 repeat 
                 eucalyptusSpp_017485 
                 Q8RXC4 
                 Hypothetical 
                 0 
                 650 
                 1348 
               
               
                   
                 protein 
                   
                   
                 144.7 kDa 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 108 
                 WD40 repeat 
                 eucalyptusSpp_018007 
                 O94289 
                 WD repeat- 
                 e−129 
                 302 
                 794 
               
               
                   
                 protein 
                   
                   
                 containing 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 109 
                 WD40 repeat 
                 eucalyptusSpp_020775 
                 Q8W403 
                 Sec13p 
                 e−150 
                 242 
                 304 
               
               
                   
                 protein 
               
               
                 110 
                 WD40 repeat 
                 eucalyptusSpp_023132 
                 AAK52092 
                 WD-40 REPEAT 
                 0 
                 458 
                 515 
               
               
                   
                 protein 
                   
                   
                 PROTEIN 
               
               
                 111 
                 WD40 repeat 
                 eucalyptusSpp_023569 
                 Q9XIJ3 
                 T10O24.21. 
                 0 
                 404 
                 576 
               
               
                   
                 protein 
                   
                   
                 SPTREMBL 
               
               
                 112 
                 WD40 repeat 
                 eucalyptusSpp_023611 
                 Q8L4J2 
                 Cleavage 
                 e−174 
                 301 
                 438 
               
               
                   
                 protein 
                   
                   
                 stimulation 
               
               
                   
                   
                   
                   
                 factor 50K 
               
               
                   
                   
                   
                   
                 chain 
               
               
                   
                   
                   
                   
                 (Cleavage 
               
               
                   
                   
                   
                   
                 stimulation 
               
               
                 113 
                 WD40 repeat 
                 eucalyptusSpp_024934 
                 Q94AB4 
                 AT3g13340/MDC11_13. 
                 0 
                 343 
                 444 
               
               
                   
                 protein 
                   
                   
                 WD- 
               
               
                   
                   
                   
                   
                 repeat 
               
               
                   
                   
                   
                   
                 protein-like 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 114 
                 WD40 repeat 
                 eucalyptusSpp_025546 
                 O22212 
                 Hypothetical 
                 0 
                 352 
                 566 
               
               
                   
                 protein 
                   
                   
                 61.8 kDa 
               
               
                   
                   
                   
                   
                 Trp-Asp 
               
               
                   
                   
                   
                   
                 repeats 
               
               
                   
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 115 
                 WD40 repeat 
                 eucalyptusSpp_030134 
                 Q9LVF2 
                 Genomic DNA, 
                 0 
                 677 
                 946 
               
               
                   
                 protein 
                   
                   
                 chromosome 
               
               
                   
                   
                   
                   
                 3, P1 clone: 
               
               
                   
                   
                   
                   
                 MIL23 
               
               
                 116 
                 WD40 repeat 
                 eucalyptusSpp_031787 
                 AAL91206 
                 WD REPEAT 
                 0 
                 264 
                 329 
               
               
                   
                 protein 
                   
                   
                 PROTEIN-LIKE 
               
               
                 117 
                 WD40 repeat 
                 eucalyptusSpp_034435 
                 Q9SAJ0 
                 F23A5.2(form 
                 e−178 
                 290 
                 349 
               
               
                   
                 protein 
                   
                   
                 2) (mRNA 
               
               
                   
                   
                   
                   
                 export 
               
               
                   
                   
                   
                   
                 protein, 
               
               
                   
                   
                   
                   
                 putative). 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 118 
                 WD40 repeat 
                 eucalyptusSpp_034452 
                 Q94BR4 
                 Hypothetical 
                 0 
                 381 
                 525 
               
               
                   
                 protein 
                   
                   
                 protein 
               
               
                   
                   
                   
                   
                 (Putative 
               
               
                   
                   
                   
                   
                 pre-mRNA 
               
               
                   
                   
                   
                   
                 splicing 
               
               
                   
                   
                   
                   
                 factor 
               
               
                 119 
                 WD40 repeat 
                 eucalyptusSpp_035789 
                 P93563 
                 Guanine 
                 3E−88 
                 171 
                 356 
               
               
                   
                 protein 
                   
                   
                 nucleotide- 
               
               
                   
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                   
                 protein beta 
               
               
                   
                   
                   
                   
                 subunit 
               
               
                 120 
                 WD40 repeat 
                 eucalyptusSpp_035804 
                 Q9FNN2 
                 WD-repeat 
                 0 
                 356 
                 589 
               
               
                   
                 protein 
                   
                   
                 protein- 
               
               
                   
                   
                   
                   
                 like. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 121 
                 WD40 repeat 
                 eucalyptusSpp_043057 
                 Q9LV35 
                 WD40-repeat 
                 0 
                 472 
                 610 
               
               
                   
                 protein 
                   
                   
                 protein. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 122 
                 WD40 repeat 
                 eucalyptusSpp_046741 
                 Q93VK1 
                 AT4g28450/F20O9_130 
                 0 
                 363 
                 452 
               
               
                   
                 protein 
               
               
                 123 
                 WD40 repeat 
                 eucalyptusSpp_047161 
                 Q9ZUN8 
                 Putative WD- 
                 0 
                 350 
                 473 
               
               
                   
                 protein 
                   
                   
                 40 repeat 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 124 
                 CDK type A 
                 pinusRadiata_001766 
                 Q9M3W7 
                 PUTATIVE 
                 e−128 
                 237 
                 436 
               
               
                   
                   
                   
                   
                 CDC2-RELATED 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                   
                   
                   
                   
                 KINASE CRK2.459 
               
               
                   
                   
                   
                   
                 e−128 
               
               
                 125 
                 CDK type A 
                 pinusRadiata_002927 
                 Q9FRN5 
                 PUTATIVE 
                 0 
                 349 
                 470 
               
               
                   
                   
                   
                   
                 SERINE/THREONINE 
               
               
                   
                   
                   
                   
                 KINASE 
               
               
                 126 
                 CDK type B-1 
                 990309PRCA009171HT 
                 Q9FYT8 
                 Cyclin- 
                 e−145 
                 244 
                 303 
               
               
                   
                   
                   
                   
                 dependent 
               
               
                   
                   
                   
                   
                 kinase B1-2 
               
               
                 127 
                 CDK type B-1 
                 pinusRadiata_013714 
                 Q9FYT8 
                 CYCLIN- 
                 e−174 
                 222 
                 304 
               
               
                   
                   
                   
                   
                 DEPENDENT 
               
               
                   
                   
                   
                   
                 KINASE B1-2 
               
               
                 128 
                 CDK type B-1 
                 pinusRadiata_016332 
                 Q9FYT8 
                 CYCLIN- 
                 e−178 
                 228 
                 304 
               
               
                   
                   
                   
                   
                 DEPENDENT 
               
               
                   
                   
                   
                   
                 KINASE B1-2 
               
               
                 129 
                 CDK type B-1 
                 pinusRadiata_021677 
                 Q9FYT8 
                 CYCLIN- 
                 e−176 
                 229 
                 304 
               
               
                   
                   
                   
                   
                 DEPENDENT 
               
               
                   
                   
                   
                   
                 KINASE B1-2 
               
               
                 130 
                 CDK type B-1 
                 pinusRadiata_027562 
                 Q9FYT8 
                 Cyclin- 
                 e−118 
                 211 
                 304 
               
               
                   
                   
                   
                   
                 dependent 
               
               
                   
                   
                   
                   
                 kinase B1-2 
               
               
                 131 
                 CDK type C 
                 pinusRadiata_001504 
                 Q9LNN0 
                 F8L10.9 
                 0 
                 434 
                 790 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 132 
                 CDK type C 
                 pinusRadiata_015211 
                 Q9LNN0 
                 F8L10.9 
                 0 
                 371 
                 746 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 133 
                 CDK type C 
                 pinusRadiata_020421 
                 P93320 
                 Cdc2MsC 
                 0 
                 318 
                 432 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 134 
                 CDK type D 
                 pinusRadiata_003187 
                 O80345 
                 CDK- 
                 e−137 
                 226 
                 485 
               
               
                   
                   
                   
                   
                 ACTIVATING 
               
               
                   
                   
                   
                   
                 KINASE 1AT 
               
               
                   
                   
                   
                   
                 (CDK- 
               
               
                   
                   
                   
                   
                 ACTIVATING 
               
               
                   
                   
                   
                   
                 KINASE 
               
               
                   
                   
                   
                   
                 CAK1AT) 
               
               
                 135 
                 CDK type D 
                 pinusRadiata_015661 
                 Q947K6 
                 CDK- 
                 0 
                 266 
                 407 
               
               
                   
                   
                   
                   
                 ACTIVATING 
               
               
                   
                   
                   
                   
                 KINASE. 
               
               
                 136 
                 Cyclin A 
                 pinusRadiata_013874 
                 Q96226 
                 Cyclin 
                 e−108 
                 223 
                 474 
               
               
                 137 
                 Cyclin A 
                 pinusRadiata_014615 
                 CAC27333 
                 PUTATIVE A- 
                 0 
                 332 
                 390 
               
               
                   
                   
                   
                   
                 LIKE CYCLIN 
               
               
                   
                   
                   
                   
                 (FRAGMENT) 
               
               
                 138 
                 Cyclin B 
                 pinusRadiata_004578 
                 O65064 
                 Probable 
                 9E−87 
                 162 
                 217 
               
               
                   
                   
                   
                   
                 G2/mitotic- 
               
               
                   
                   
                   
                   
                 specific 
               
               
                   
                   
                   
                   
                 cyclin 
               
               
                   
                   
                   
                   
                 (Fragment) 
               
               
                 139 
                 Cyclin B 
                 pinusRadiata_023387 
                 O04389 
                 B-like 
                 2E−98 
                 220 
                 466 
               
               
                   
                   
                   
                   
                 cyclin 
               
               
                 140 
                 Cyclin D 
                 pinusRadiata_006970 
                 P93103 
                 CYCLIN-D 
                 1E−75 
                 135 
                 293 
               
               
                   
                   
                   
                   
                 LIKE PROTEIN 
               
               
                 141 
                 Cyclin D 
                 pinusRadiata_010322 
                 CAC17049 
                 SEQUENCE 33 
                 e−131 
                 171 
                 254 
               
               
                   
                   
                   
                   
                 FROM PATENT 
               
               
                   
                   
                   
                   
                 WO0065040 
               
               
                 142 
                 Cyclin D 
                 pinusRadiata_022721 
                 P93103 
                 CYCLIN-D 
                 1E−76 
                 137 
                 289 
               
               
                   
                   
                   
                   
                 LIKE PROTEIN 
               
               
                 143 
                 Cyclin D 
                 pinusRadiata_023407 
                 Q9SMD5 
                 CYCD3,2 
                 8E−90 
                 139 
                 278 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 144 
                 Cyclin- 
                 pinusRadiata_001945 
                 Q947Y1 
                 PUTATIVE 
                 5E−55 
                 74 
                 86 
               
               
                   
                 dependent 
                   
                   
                 CYCLIN- 
               
               
                   
                 kinase 
                   
                   
                 DEPENDENT 
               
               
                   
                 regulatory 
                   
                   
                 KINASE 
               
               
                   
                 subunit 
                   
                   
                 REGULATORY 
               
               
                   
                   
                   
                   
                 SUBUNIT 
               
               
                 145 
                 Cyclin- 
                 pinusRadiata_008233 
                 CAB69358 
                 SEQUENCE 1 
                 4E−49 
                 65 
                 86 
               
               
                   
                 dependent 
                   
                   
                 FROM PATENT 
               
               
                   
                 kinase 
                   
                   
                 WO9841642 
               
               
                   
                 regulatory 
               
               
                   
                 subunit 
               
               
                 146 
                 Cyclin- 
                 pinusRadiata_008234 
                 CAB69358 
                 SEQUENCE 1 
                 4E−49 
                 65 
                 86 
               
               
                   
                 dependent 
                   
                   
                 FROM PATENT 
               
               
                   
                 kinase 
                   
                   
                 WO9841642 
               
               
                   
                 regulatory 
               
               
                   
                 subunit 
               
               
                 147 
                 Cyclin- 
                 pinusRadiata_022054 
                 CAB69358 
                 SEQUENCE 1 
                 8E−55 
                 70 
                 82 
               
               
                   
                 dependent 
                   
                   
                 FROM PATENT 
               
               
                   
                 kinase 
                   
                   
                 WO9841642 
               
               
                   
                 regulatory 
               
               
                   
                 subunit 
               
               
                 148 
                 Histone 
                 pinusRadiata_012137 
                 Q9FK40 
                 Histone 
                 0 
                 496 
                 555 
               
               
                   
                 acetyltransferase 
                   
                   
                 acetyltransferase 
               
               
                   
                   
                   
                   
                 (AT5g50320/MXI22_3) 
               
               
                 149 
                 Histone 
                 pinusRadiata_012582 
                 O80378 
                 181 
                 0 
                 354 
                 402 
               
               
                   
                 acetyltransferase 
                   
                   
                 (Fragment) 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 150 
                 Histone 
                 pinusRadiata_015285 
                 O80378 
                 181 
                 0 
                 342 
                 401 
               
               
                   
                 acetyltransferase 
                   
                   
                 (Fragment) 
               
               
                 151 
                 Histone 
                 pinusRadiata_017229 
                 Q9LNC4 
                 F9P14.9 
                 e−118 
                 268 
                 585 
               
               
                   
                 acetyltransferase 
                   
                   
                 protein 
               
               
                 152 
                 Histone 
                 pinusRadiata_020724 
                 Q9AR19 
                 Histone 
                 e−177 
                 355 
                 639 
               
               
                   
                 acetyltransferase 
                   
                   
                 acetyltransferase 
               
               
                   
                   
                   
                   
                 GCN5 
               
               
                   
                   
                   
                   
                 (Expressed 
               
               
                   
                   
                   
                   
                 protein) 
               
               
                 153 
                 Histone 
                 pinusRadiata_004555 
                 AAM13152 
                 HISTONE 
                 0 
                 331 
                 488 
               
               
                   
                 deacetylase 
                   
                   
                 DEACETYLASE 
               
               
                 154 
                 Histone 
                 pinusRadiata_004556 
                 AAM13152 
                 HISTONE 
                 0 
                 331 
                 488 
               
               
                   
                 deacetylase 
                   
                   
                 DEACETYLASE 
               
               
                 155 
                 Histone 
                 pinusRadiata_005729 
                 Q9M4U5 
                 Histone 
                 9E−62 
                 154 
                 348 
               
               
                   
                 deacetylase 
                   
                   
                 deacetylase 
               
               
                   
                   
                   
                   
                 2 isoform b 
               
               
                 156 
                 Histone 
                 pinusRadiata_007395 
                 AAM13152 
                 HISTONE 
                 0 
                 335 
                 426 
               
               
                   
                 deacetylase 
                   
                   
                 DEACETYLASE 
               
               
                 157 
                 Histone 
                 pinusRadiata_009503 
                 Q8W508 
                 Histone 
                 0 
                 365 
                 427 
               
               
                   
                 deacetylase 
                   
                   
                 deacetylase 
               
               
                 158 
                 Histone 
                 pinusRadiata_011283 
                 AAM19887 
                 AT1G08460/T27G7_7 
                 0 
                 255 
                 366 
               
               
                   
                 deacetylase 
               
               
                 159 
                 Histone 
                 pinusRadiata_012322 
                 Q9FML2 
                 HISTONE 
                 0 
                 327 
                 435 
               
               
                   
                 deacetylase 
                   
                   
                 DEACETYLASE 
               
               
                   
                   
                   
                   
                 (PUTATIVE 
               
               
                   
                   
                   
                   
                 HISTONE 
               
               
                   
                   
                   
                   
                 DEACETYLASE) 
               
               
                 161 
                 Histone 
                 pinusRadiata_023236 
                 Q8RX28 
                 Putative 
                 e−144 
                 238 
                 390 
               
               
                   
                 deacetylase 
                   
                   
                 histone 
               
               
                   
                   
                   
                   
                 deacetylase 
               
               
                 162 
                 Peptidylprolyl 
                 pinusRadiata_000171 
                 Q9FJL3 
                 PEPTIDYLPROLYL 
                 0 
                 364 
                 549 
               
               
                   
                 isomerase 
                   
                   
                 ISOMERASE 
               
               
                 163 
                 Peptidylprolyl 
                 pinusRadiata_000172 
                 Q38949 
                 FK506 
                 0 
                 365 
                 552 
               
               
                   
                 isomerase 
                   
                   
                 BINDING 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                   
                   
                   
                   
                 FKBP62 
               
               
                   
                   
                   
                   
                 (ROF1) 
               
               
                 164 
                 Peptidylprolyl 
                 pinusRadiata_001480 
                 Q8VXA5 
                 PUTATIVE 
                 e−125 
                 161 
                 172 
               
               
                   
                 isomerase 
                   
                   
                 CYCLOSPORIN 
               
               
                   
                   
                   
                   
                 A-BINDING 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 168 
                 Peptidylprolyl 
                 pinusRadiata_001692 
                 FKB7_WHEAT 
                 70 kDa 
                 0 
                 418 
                 553 
               
               
                   
                 isomerase 
                   
                   
                 peptidylprolyl 
               
               
                   
                   
                   
                   
                 isomerase 
               
               
                   
                   
                   
                   
                 (EC 5.2.1.8) 
               
               
                 169 
                 Peptidylprolyl 
                 pinusRadiata_005313 
                 AAB64339 
                 FKBP-TYPE 
                 1E−97 
                 135 
                 175 
               
               
                   
                 isomerase 
                   
                   
                 PEPTIDYL- 
               
               
                   
                   
                   
                   
                 PROLYL CIS- 
               
               
                   
                   
                   
                   
                 TRANS 
               
               
                   
                   
                   
                   
                 ISOMERASE 
               
               
                 170 
                 Peptidylprolyl 
                 pinusRadiata_006362 
                 BAB39983 
                 PUTATIVE 
                 3E−77 
                 129 
                 168 
               
               
                   
                 isomerase 
                   
                   
                 PEPTIDYL- 
               
               
                   
                   
                   
                   
                 PROLYL CIS- 
               
               
                   
                   
                   
                   
                 TRANS 
               
               
                   
                   
                   
                   
                 ISOMERASE, 
               
               
                   
                   
                   
                   
                 CHLOROPLA . . . 
               
               
                   
                   
                   
                   
                 290 3e−77 
               
               
                 171 
                 Peptidylprolyl 
                 pinusRadiata_006493 
                 Q9C835 
                 Hypothetical 
                 2E−62 
                 128 
                 235 
               
               
                   
                 isomerase 
                   
                   
                 26.4 kDa 
               
               
                   
                   
                   
                   
                 protein (EC 
               
               
                   
                   
                   
                   
                 5.2.1.8) 
               
               
                   
                   
                   
                   
                 (Peptidyl- 
               
               
                   
                   
                   
                   
                 prol . . . 
               
               
                 172 
                 Peptidylprolyl 
                 pinusRadiata_006983 
                 AAK96784 
                 CYCLOPHILIN 
                 e−103 
                 151 
                 204 
               
               
                   
                 isomerase 
               
               
                 174 
                 Peptidylprolyl 
                 pinusRadiata_007665 
                 Q9LDC0 
                 FKBP-like 
                 e−138 
                 239 
                 378 
               
               
                   
                 isomerase 
                   
                   
                 protein 
               
               
                   
                   
                   
                   
                 (Genomic 
               
               
                   
                   
                   
                   
                 DNA, 
               
               
                   
                   
                   
                   
                 chromosome 
               
               
                   
                   
                   
                   
                 3, P1 clone: 
               
               
                 175 
                 Peptidylprolyl 
                 pinusRadiata_012196 
                 Q93VG0 
                 Cyclophilin 
                 4E−74 
                 132 
                 160 
               
               
                   
                 isomerase 
                   
                   
                 (EC 5.2.1.8) 
               
               
                   
                   
                   
                   
                 (Peptidyl- 
               
               
                   
                   
                   
                   
                 prolyl cis- 
               
               
                   
                   
                   
                   
                 trans 
               
               
                 176 
                 Peptidylprolyl 
                 pinusRadiata_013382 
                 Q9C588 
                 HYPOTHETICAL 
                 0 
                 288 
                 581 
               
               
                   
                 isomerase 
                   
                   
                 60.2 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 177 
                 Peptidylprolyl 
                 pinusRadiata_016461 
                 O04287 
                 IMMUNOPHILIN 
                 9E−66 
                 88 
                 109 
               
               
                   
                 isomerase 
               
               
                 178 
                 Peptidylprolyl 
                 pinusRadiata_017611 
                 Q9C566 
                 Cyclophilin- 
                 e−163 
                 276 
                 360 
               
               
                   
                 isomerase 
                   
                   
                 40 (EC 
               
               
                   
                   
                   
                   
                 5.2.1.8) 
               
               
                   
                   
                   
                   
                 (Expressed 
               
               
                   
                   
                   
                   
                 protein) 
               
               
                 179 
                 Peptidylprolyl 
                 pinusRadiata_019776 
                 AAM14253 
                 HYPOTHETICAL 
                 e−110 
                 146 
                 190 
               
               
                   
                 isomerase 
                   
                   
                 20.3 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 180 
                 Peptidylprolyl 
                 pinusRadiata_020659 
                 AAO63961 
                 Hypothetical 
                 7E−85 
                 159 
                 227 
               
               
                   
                 isomerase 
                   
                   
                 protein 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 181 
                 Peptidylprolyl 
                 pinusRadiata_022559 
                 AAK43974 
                 PUTATIVE 
                 2E−73 
                 113 
                 153 
               
               
                   
                 isomerase 
                   
                   
                 PEPTIDYL- 
               
               
                   
                   
                   
                   
                 PROLYL CIS- 
               
               
                   
                   
                   
                   
                 TRANS 
               
               
                   
                   
                   
                   
                 ISOMERASE 
               
               
                 182 
                 Peptidylprolyl 
                 pinusRadiata_024188 
                 Q9P3X9 
                 PEPTIDYL- 
                 e−122 
                 210 
                 379 
               
               
                   
                 isomerase 
                   
                   
                 PROLYL CIS- 
               
               
                   
                   
                   
                   
                 TRANS 
               
               
                   
                   
                   
                   
                 ISOMERASE 
               
               
                   
                   
                   
                   
                 (EC 5.2.1.8) 
               
               
                 183 
                 Peptidylprolyl 
                 pinusRadiata_027973 
                 Q9SR70 
                 T22K18.11 
                 3E−69 
                 125 
                 171 
               
               
                   
                 isomerase 
                   
                   
                 protein 
               
               
                   
                   
                   
                   
                 (AT3g10060/T22K18_11) 
               
               
                 184 
                 WD40 repeat 
                 pinusRadiata_001353 
                 Q9FNN2 
                 WD-repeat 
                 0 
                 317 
                 590 
               
               
                   
                 protein 
                   
                   
                 protein- 
               
               
                   
                   
                   
                   
                 likeSPTREMBL 
               
               
                 185 
                 WD40 repeat 
                 pinusRadiata_001978 
                 PRL1_ARATH 
                 PP1/PP2A 
                 0 
                 341 
                 502 
               
               
                   
                 protein 
                   
                   
                 phosphatases 
               
               
                   
                   
                   
                   
                 pleiotropic 
               
               
                   
                   
                   
                   
                 regulator 
               
               
                   
                   
                   
                   
                 PRL1 
               
               
                 186 
                 WD40 repeat 
                 pinusRadiata_002810 
                 AAK49947 
                 TGF-BETA 
                 0 
                 273 
                 326 
               
               
                   
                 protein 
                   
                   
                 RECEPTOR- 
               
               
                   
                   
                   
                   
                 INTERACTING 
               
               
                   
                   
                   
                   
                 PROTEIN 1 
               
               
                 187 
                 WD40 repeat 
                 pinusRadiata_002811 
                 AAK49947 
                 TGF-BETA 
                 0 
                 273 
                 326 
               
               
                   
                 protein 
                   
                   
                 RECEPTOR- 
               
               
                   
                   
                   
                   
                 INTERACTING 
               
               
                   
                   
                   
                   
                 PROTEIN 1 
               
               
                 188 
                 WD40 repeat 
                 pinusRadiata_002812 
                 AAM15129 
                 HYPOTHETICAL 
                 e−127 
                 225 
                 521 
               
               
                   
                 protein 
                   
                   
                 58.9 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 189 
                 WD40 repeat 
                 pinusRadiata_003514 
                 Q9FJ94 
                 Similarity 
                 e−137 
                 242 
                 445 
               
               
                   
                 protein 
                   
                   
                 to myosin 
               
               
                   
                   
                   
                   
                 heavy chain 
               
               
                   
                   
                   
                   
                 kinaseSPTREMBL 
               
               
                 190 
                 WD40 repeat 
                 pinusRadiata_004104 
                 GBB_ORYSA 
                 Guanine 
                 0 
                 294 
                 378 
               
               
                   
                 protein 
                   
                   
                 nucleotide- 
               
               
                   
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                   
                 protein beta 
               
               
                   
                   
                   
                   
                 subunit 
               
               
                 191 
                 WD40 repeat 
                 pinusRadiata_005595 
                 Q9FTT9 
                 PUTATIVE 
                 0 
                 320 
                 459 
               
               
                   
                 protein 
                   
                   
                 DKFZP564O0463 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 192 
                 WD40 repeat 
                 pinusRadiata_005754 
                 Q94JT6 
                 At1g78070/F28K19_28SPTREMBL 
                 e−168 
                 294 
                 451 
               
               
                   
                 protein 
               
               
                 193 
                 WD40 repeat 
                 pinusRadiata_006463 
                 GBLP_MEDSA 
                 Guanine 
                 e−152 
                 261 
                 324 
               
               
                   
                 protein 
                   
                   
                 nucleotide- 
               
               
                   
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                   
                 protein beta 
               
               
                   
                   
                   
                   
                 subunit-like . . . 
               
               
                   
                   
                   
                   
                 538 e−152 
               
               
                 194 
                 WD40 repeat 
                 pinusRadiata_006665 
                 AAM20553 
                 HYPOTHETICAL 
                 0 
                 655 
                 1169 
               
               
                   
                 protein 
                   
                   
                 119.9 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN. 
               
               
                   
                   
                   
                   
                 1229 0.0 
               
               
                 195 
                 WD40 repeat 
                 pinusRadiata_006750 
                 AAM13119 
                 HYPOTHETICAL 
                 e−158 
                 264 
                 312 
               
               
                   
                 protein 
                   
                   
                 35.4 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN. 560 
               
               
                   
                   
                   
                   
                 e−158 
               
               
                 196 
                 WD40 repeat 
                 pinusRadiata_007030 
                 Q9LJN8 
                 MITOTIC 
                 e−169 
                 284 
                 335 
               
               
                   
                 protein 
                   
                   
                 CHECKPOINT 
               
               
                   
                   
                   
                   
                 PROTEIN. 595 
               
               
                   
                   
                   
                   
                 e−169 
               
               
                 197 
                 WD40 repeat 
                 pinusRadiata_007854 
                 Q8H919 
                 Putative WD 
                 0 
                 429 
                 644 
               
               
                   
                 protein 
                   
                   
                 domain 
               
               
                   
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 198 
                 WD40 repeat 
                 pinusRadiata_007917 
                 AAD10151 
                 PUTATIVE WD- 
                 0 
                 353 
                 462 
               
               
                   
                 protein 
                   
                   
                 40 REPEAT 
               
               
                   
                   
                   
                   
                 PROTEIN, 
               
               
                   
                   
                   
                   
                 MSI4 
               
               
                 199 
                 WD40 repeat 
                 pinusRadiata_007989 
                 Q9LRZ0 
                 Genomic DNA, 
                 0 
                 480 
                 687 
               
               
                   
                 protein 
                   
                   
                 chromosome 
               
               
                   
                   
                   
                   
                 3, TAC 
               
               
                   
                   
                   
                   
                 clone: K20I9 
               
               
                 200 
                 WD40 repeat 
                 pinusRadiata_008506 
                 MSI1_LYCES 
                 WD-40 repeat 
                 0 
                 364 
                 420 
               
               
                   
                 protein 
                   
                   
                 protein MSI1 
               
               
                 201 
                 WD40 repeat 
                 pinusRadiata_008692 
                 Q8W403 
                 Sec13p 
                 e−134 
                 218 
                 301 
               
               
                   
                 protein 
               
               
                 202 
                 WD40 repeat 
                 pinusRadiata_008693 
                 Q8W403 
                 Sec13p 
                 e−137 
                 222 
                 301 
               
               
                   
                 protein 
               
               
                 203 
                 WD40 repeat 
                 pinusRadiata_009170 
                 Q9M0V4 
                 U3 snoRNP- 
                 e−127 
                 244 
                 524 
               
               
                   
                 protein 
                   
                   
                 associated- 
               
               
                   
                   
                   
                   
                 like 
               
               
                   
                   
                   
                   
                 protein. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 204 
                 WD40 repeat 
                 pinusRadiata_009408 
                 Q9SAJ0 
                 F23A5.2(FORM 
                 e−171 
                 282 
                 350 
               
               
                   
                 protein 
                   
                   
                 2). 602 e−171 
               
               
                 205 
                 WD40 repeat 
                 pinusRadiata_009522 
                 Q8RXQ4 
                 Hypothetical 
                 e−129 
                 231 
                 395 
               
               
                   
                 protein 
                   
                   
                 43.8 kDa 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 206 
                 WD40 repeat 
                 pinusRadiata_009734 
                 AAO27452 
                 Peroxisomal 
                 e−142 
                 227 
                 317 
               
               
                   
                 protein 
                   
                   
                 targeting 
               
               
                   
                   
                   
                   
                 signal type 
               
               
                   
                   
                   
                   
                 2 receptor. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 207 
                 WD40 repeat 
                 pinusRadiata_009815 
                 AAM20433 
                 CELL CYCLE 
                 0 
                 326 
                 500 
               
               
                   
                 protein 
                   
                   
                 SWITCH 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 208 
                 WD40 repeat 
                 pinusRadiata_010670 
                 AAN72058 
                 Expressed 
                 e−157 
                 264 
                 345 
               
               
                   
                 protein 
                   
                   
                 protein 
               
               
                 209 
                 WD40 repeat 
                 pinusRadiata_011297 
                 AAM13100 
                 WD REPEAT 
                 e−157 
                 262 
                 337 
               
               
                   
                 protein 
                   
                   
                 PROTEIN 
               
               
                   
                   
                   
                   
                 ATAN11 
               
               
                 210 
                 WD40 repeat 
                 pinusRadiata_013098 
                 AAM13153 
                 HYPOTHETICAL 
                 e−136 
                 229 
                 352 
               
               
                   
                 protein 
                   
                   
                 39.1 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN. 487 
               
               
                   
                   
                   
                   
                 e−136 
               
               
                 211 
                 WD40 repeat 
                 pinusRadiata_013172 
                 Q8H0T9 
                 Hypothetical 
                 0 
                 437 
                 860 
               
               
                   
                 protein 
                   
                   
                 protein 
               
               
                 212 
                 WD40 repeat 
                 pinusRadiata_013589 
                 AAK52092 
                 WD-40 REPEAT 
                 0 
                 448 
                 512 
               
               
                   
                 protein 
                   
                   
                 PROTEIN 
               
               
                 213 
                 WD40 repeat 
                 pinusRadiata_013608 
                 AAC27402 
                 EXPRESSED 
                 e−141 
                 202 
                 358 
               
               
                   
                 protein 
                   
                   
                 PROTEIN 
               
               
                 214 
                 WD40 repeat 
                 pinusRadiata_014299 
                 Q9XED5 
                 Cell cycle 
                 0 
                 335 
                 488 
               
               
                   
                 protein 
                   
                   
                 switch 
               
               
                   
                   
                   
                   
                 proteinSPTREMBL 
               
               
                 215 
                 WD40 repeat 
                 pinusRadiata_014498 
                 Q9FH64 
                 WD REPEAT 
                 e−152 
                 206 
                 329 
               
               
                   
                 protein 
                   
                   
                 PROTEIN-LIKE 
               
               
                 216 
                 WD40 repeat 
                 pinusRadiata_014548 
                 Q93ZS6 
                 HYPOTHETICAL 
                 0 
                 505 
                 763 
               
               
                   
                 protein 
                   
                   
                 82.2 KDA 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 217 
                 WD40 repeat 
                 pinusRadiata_014610 
                 Q9M298 
                 Hypothetical 
                 0 
                 450 
                 922 
               
               
                   
                 protein 
                   
                   
                 104.7 kDa 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 218 
                 WD40 repeat 
                 pinusRadiata_016090 
                 Q9SIY9 
                 Putative WD- 
                 0 
                 442 
                 802 
               
               
                   
                 protein 
                   
                   
                 40 repeat 
               
               
                   
                   
                   
                   
                 proteinSPTREMBL 
               
               
                 219 
                 WD40 repeat 
                 pinusRadiata_016722 
                 O22826 
                 Putative 
                 e−159 
                 257 
                 310 
               
               
                   
                 protein 
                   
                   
                 splicing 
               
               
                   
                   
                   
                   
                 factorSPTREMBL 
               
               
                 220 
                 WD40 repeat 
                 pinusRadiata_016785 
                 AAG60193 
                 PUTATIVE 
                 0 
                 344 
                 464 
               
               
                   
                 protein 
                   
                   
                 WD40 PROTEIN 
               
               
                 221 
                 WD40 repeat 
                 pinusRadiata_017094 
                 Q9LV35 
                 WD40-REPEAT 
                 0 
                 406 
                 604 
               
               
                   
                 protein 
                   
                   
                 PROTEIN 
               
               
                 222 
                 WD40 repeat 
                 pinusRadiata_017527 
                 Q9AYE4 
                 Hypothetical 
                 e−154 
                 254 
                 314 
               
               
                   
                 protein 
                   
                   
                 35.3 kDa 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 223 
                 WD40 repeat 
                 pinusRadiata_017591 
                 O80706 
                 F8K4.21 
                 0 
                 905 
                 1218 
               
               
                   
                 protein 
                   
                   
                 protein 
               
               
                 224 
                 WD40 repeat 
                 pinusRadiata_017769 
                 Q9XIJ3 
                 T10O24.21 
                 0 
                 446 
                 607 
               
               
                   
                 protein 
               
               
                 225 
                 WD40 repeat 
                 pinusRadiata_018047 
                 Q8VZY6 
                 FERTILIZATION- 
                 0 
                 285 
                 373 
               
               
                   
                 protein 
                   
                   
                 INDEPENDENT 
               
               
                   
                   
                   
                   
                 ENDOSPERM 
               
               
                   
                   
                   
                   
                 PROTEIN 
               
               
                 226 
                 WD40 repeat 
                 pinusRadiata_018414 
                 Q947M8 
                 COPI 
                 0 
                 455 
                 638 
               
               
                   
                 protein 
               
               
                 227 
                 WD40 repeat 
                 pinusRadiata_018986 
                 Q9LFE2 
                 WD40-repeat 
                 0 
                 518 
                 886 
               
               
                   
                 protein 
                   
                   
                 protein 
               
               
                 228 
                 WD40 repeat 
                 pinusRadiata_019479 
                 Q9SZA4 
                 WD-repeat 
                 e−156 
                 276 
                 454 
               
               
                   
                 protein 
                   
                   
                 protein-like 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 229 
                 WD40 repeat 
                 pinusRadiata_020144 
                 Q8W514 
                 MSI TYPE 
                 0 
                 288 
                 413 
               
               
                   
                 protein 
                   
                   
                 NUCLEOSOME/CHROMATIN 
               
               
                   
                   
                   
                   
                 ASSEMBLY 
               
               
                   
                   
                   
                   
                 FACTOR C 
               
               
                 230 
                 WD40 repeat 
                 pinusRadiata_022480 
                 Q8W514 
                 MSI type 
                 e−167 
                 287 
                 426 
               
               
                   
                 protein 
                   
                   
                 nucleosome/chromatin 
               
               
                   
                   
                   
                   
                 assembly 
               
               
                   
                   
                   
                   
                 factor C 
               
               
                 231 
                 WD40 repeat 
                 pinusRadiata_023079 
                 Q8W514 
                 MSI type 
                 e−169 
                 283 
                 397 
               
               
                   
                 protein 
                   
                   
                 nucleosome/chromatin 
               
               
                   
                   
                   
                   
                 assembly 
               
               
                   
                   
                   
                   
                 factor C. SPTREMBL 
               
               
                 232 
                 WD40 repeat 
                 pinusRadiata_026739 
                 Q93YS7 
                 Putative WD- 
                 0 
                 591 
                 918 
               
               
                   
                 protein 
                   
                   
                 repeat 
               
               
                   
                   
                   
                   
                 membrane 
               
               
                   
                   
                   
                   
                 protein. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 233 
                 WD40 repeat 
                 pinusRadiata_026951 
                 Q93VS5 
                 AT4g18900/F13C5_70 
                 e−163 
                 290 
                 503 
               
               
                   
                 protein 
                   
                   
                 (Hypothetical 
               
               
                   
                   
                   
                   
                 protein) 
               
               
                 234 
                 WEE1-like 
                 pinusRadiata_026529 
                 Q9SRY9 
                 F22D16.3 
                 e−122 
                 209 
                 451 
               
               
                   
                 protein 
                   
                   
                 PROTEIN 
               
               
                 235 
                 WD40 repeat 
                 eucalyptusSpp_006366 
                 Q8LF96 
                 PRL1 protein 
                 0 
                 374 
                 492 
               
               
                   
                 protein 
               
               
                 236 
                 WD40 repeat 
                 eucalyptusSpp_017378 
                 O22607 
                 WD-40 repeat 
                 0 
                 371 
                 453 
               
               
                   
                 protein 
                   
                   
                 protein MSI4 
               
               
                 237 
                 WD40 repeat 
                 pinusRadiata_000888 
                 O22466 
                 WD-40 repeat 
                 0 
                 364 
                 420 
               
               
                   
                 protein 
                   
                   
                 protein MSI1 
               
               
                 238 
                 Cyclin- 
                 pinusRadiata_014166 
                 Q9FKB5 
                 GENOMIC DNA, 
                 5E−42 
                 114 
                 304 
               
               
                   
                 dependant 
                   
                   
                 CHROMOSOME 
               
               
                   
                 kinase 
                   
                   
                 5, TAC 
               
               
                   
                 inhibitor 
                   
                   
                 CLONE: K24G6 
               
               
                   
                   
                   
                   
                 (CYCLIN- 
               
               
                   
                   
                   
                   
                 DEPENDENT 
               
               
                 239 
                 CDK type D 
                 pinusRadiata_003189 
                 Q9M5G4 
                 CDK- 
                 8E−21 
                 56 
                 100 
               
               
                   
                   
                   
                   
                 activating 
               
               
                   
                   
                   
                   
                 kinase 
               
               
                 240 
                 Histone 
                 pinusRadiata_009356 
                 Q9FJT8 
                 Histone 
                 7E−85 
                 187 
                 510 
               
               
                   
                 acetyltransferase 
                   
                   
                 acetyltransferase 
               
               
                   
                   
                   
                   
                 HAT B 
               
               
                 241 
                 Histone 
                 pinusRadiata_000065 
                 Q9LPW6 
                 F13K23.8 
                 5E−18 
                 71 
                 209 
               
               
                   
                 deacetylase 
                   
                   
                 protein. 
               
               
                 242 
                 Histone 
                 pinusRadiata_014197 
                 Q8GXJ1 
                 Putative 
                 e−170 
                 308 
                 519 
               
               
                   
                 deacetylase 
                   
                   
                 histone 
               
               
                   
                   
                   
                   
                 deacetylase 
               
               
                 243 
                 Peptidylprolyl 
                 pinusRadiata_009081 
                 Q9ZRQ9 
                 Cyclophilin 
                 e−106 
                 185 
                 190 
               
               
                   
                 isomerase 
                   
                   
                 (EC 5.2.1.8) 
               
               
                   
                   
                   
                   
                 (Peptidyl- 
               
               
                   
                   
                   
                   
                 prolyl cis- 
               
               
                   
                   
                   
                   
                 trans 
               
               
                 244 
                 Peptidyprolyl 
                 pinusRadiata_013417 
                 Q8H4T0 
                 Putative 
                 e−140 
                 235 
                 345 
               
               
                   
                 isomerase 
                   
                   
                 peptidyl- 
               
               
                   
                   
                   
                   
                 prolycis- 
               
               
                   
                   
                   
                   
                 trans 
               
               
                   
                   
                   
                   
                 isomerase 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 245 
                 WD40 repeat 
                 pinusRadiata_005755 
                 Q9SKW4 
                 F5J5.6. 
                 e−143 
                 144 
                 319 
               
               
                   
                 protein 
               
               
                 246 
                 WD40 repeat 
                 pinusRadiata_006670 
                 Q9LDG7 
                 WD-40 repeat 
                 e−163 
                 393 
                 960 
               
               
                   
                 protein 
                   
                   
                 protein-like 
               
               
                   
                   
                   
                   
                 (MJK13.13 
               
               
                   
                   
                   
                   
                 protein) 
               
               
                 247 
                 WD40 repeat 
                 pinusRadiata_007027 
                 Q8GWR1 
                 Hypothetical 
                 e−157 
                 276 
                 470 
               
               
                   
                 protein 
                   
                   
                 protein. 
               
               
                 248 
                 WD40 repeat 
                 pinusRadiata_007276 
                 Q9LF27 
                 Hypothetical 
                 e−138 
                 235 
                 428 
               
               
                   
                 protein 
                   
                   
                 47.3 kDa 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 249 
                 WD40 repeat 
                 pinusRadiata_007390 
                 Q94AH4 
                 PUTATIVE 
                 3E−17 
                 53 
                 158 
               
               
                   
                 protein 
                   
                   
                 RING ZINC 
               
               
                   
                   
                   
                   
                 FINGER 
               
               
                   
                   
                   
                   
                 PROTEIN. 91 
               
               
                   
                   
                   
                   
                 3e−17 
               
               
                 250 
                 WD40 repeat 
                 pinusRadiata_012648 
                 O22212 
                 Hypothetical 
                 0 
                 324 
                 561 
               
               
                   
                 protein 
                   
                   
                 61.8 kDa 
               
               
                   
                   
                   
                   
                 Trp-Asp 
               
               
                   
                   
                   
                   
                 repeats 
               
               
                   
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 251 
                 WD40 repeat 
                 pinusRadiata_013171 
                 Q8H0T9 
                 Hypothetical 
                 0 
                 437 
                 860 
               
               
                   
                 protein 
                   
                   
                 protein. 
               
               
                 252 
                 Cyclin B 
                 eucalyptusSpp_045414 
                 Q9LDM4 
                 F2D10.10 
                 e−142 
                 255 
                 423 
               
               
                   
                   
                   
                   
                 (F5M15.6) 
               
               
                 253 
                 Cyclin- 
                 eucalyptusSpp_044328 
                 Q9FKB5 
                 GENOMIC DNA, 
                 1E−54 
                 121 
                 260 
               
               
                   
                 dependant 
                   
                   
                 CHROMOSOME 
               
               
                   
                 kinase 
                   
                   
                 5, TAC 
               
               
                   
                 inhibitor 
                   
                   
                 CLONE: K24G6 
               
               
                   
                   
                   
                   
                 (CYCLIN- 
               
               
                   
                   
                   
                   
                 DEPENDENT 
               
               
                 254 
                 Histone 
                 eucalyptusSpp_015615 
                 Q9AR19 
                 Histone 
                 0 
                 390 
                 563 
               
               
                   
                 acetyltransferase 
                   
                   
                 acetyltransferase 
               
               
                   
                   
                   
                   
                 GCN5 
               
               
                   
                   
                   
                   
                 (Expressed 
               
               
                   
                   
                   
                   
                 protein) 
               
               
                 255 
                 Peptidylprolyl 
                 eucalyptusSpp_017239 
                 Q8GWM6 
                 Hypothetical 
                 0 
                 364 
                 591 
               
               
                   
                 isomerase 
                   
                   
                 protein 
               
               
                 256 
                 WD40 repeat 
                 eucalyptusSpp_018643 
                 Q93VS5 
                 AT4g18900/F13C5_70 
                 0 
                 229 
                 327 
               
               
                   
                 protein 
                   
                   
                 (Hypothetical 
               
               
                   
                   
                   
                   
                 protein) 
               
               
                 257 
                 WD40 repeat 
                 eucalyptusSpp_019127 
                 Q9SRX9 
                 F22D16.14 
                 e−131 
                 232 
                 337 
               
               
                   
                 protein 
                   
                   
                 protein. 
               
               
                   
                   
                   
                   
                 SPTREMBL 
               
               
                 258 
                 WD40 repeat 
                 eucalyptusSpp_022624 
                 Q9LFE2 
                 WD40-repeat 
                 0 
                 594 
                 868 
               
               
                   
                 protein 
                   
                   
                 protein 
               
               
                 259 
                 WD40 repeat 
                 eucalyptusSpp_032424 
                 Q8LPL5 
                 Cell cycle 
                 0 
                 255 
                 327 
               
               
                   
                 protein 
                   
                   
                 switch 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 260 
                 WD40 repeat 
                 eucalyptusSpp_037472 
                 Q9SK69 
                 Putative WD- 
                 0 
                 461 
                 677 
               
               
                   
                 protein 
                   
                   
                 40 repeat 
               
               
                   
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                   
                 (AT2G20330/F11A3.12)