Patent Publication Number: US-6908942-B2

Title: 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives and their construction by parallel synthesis on solid-phase

Description:
BACKGROUND OF THE INVENTION 
     1. Field of the Invention 
     The present invention relates to (i) 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives; (ii) a process for synthesizing the novel benzopyran derivatives with high efficiency by parallel synthesis on solid-phase as one of combinatorial chemical synthesis technologies; and (iii) a use of the novel benzopyran derivatives for preventing and treating diseases or disorders induced by promotion of lipid peroxidation or accumulation of oxidized products. 
     2. Description of the Related Art 
     It has been suggested that the injury or death (e.g., apoptosis) of nerve cells is mainly responsible for several neurologic diseases or disorders such as apoplexy, brain trauma, Alzheimer&#39;s disease and Parkinson&#39;s disease (G. J. Zoppo et al.,  Drugs  54, 9 (1997); and I. Sziraki et al.,  Neurosci.  85, 1101 (1998)). The factors involved in the injury of nerve cells have been known, which include the elevation of the levels of iron, activated oxygen species and oxidized molecules in nerve cells (M. P. Mattson et al.,  Methods Cell Biol.  46, 187 (1995); and Y. Goodman et al.,  Brain Res.  706, 328 (1996)). 
     The elevated level of iron in nerve cells leads to the formation of oxygen free radicals such as NO and then promotion of lipid peroxidation, which results in the accumulation of oxidized molecules in cells. The oxidized molecules accumulated in cells give rise to inflammatory diseases, cardiac infarction and dementia as well as neurologic diseases described above. In addition, the oxidized molecules have been reported to lead to acute or chronic tissue or organ injury. Such injuries include organ injury by endotoxins from bacteria infection or tissue injury occurring when the reperfusion in ischemic disease is performed. 
     Therefore, in order to prevent and treat several diseases due to the injury or death of nerve cells, many researchers have made extensive study to develop novel substances capable of preventing injury of nerve cells due to elevated irons in nerve cells, lipid peroxidation and generation of NO due to endotoxins. The antioxidants have been reported to alleviate injury and death of nerve cells due to irons, and the endeavor to develop novel drugs for preventing injury of nerve cells due to oxidative stress is under way (Y. Zhang et al.,  J. Cereb. Blood Flow Metab.  13, 378 (1993)). 
     Natural and synthetic products having benzopyran skeleton have been widely known and used as a basic skeletal structure for developing compounds exhibiting therapeutical efficacy in several diseases such as nerve-related diseases, hypertension and diabetes owing to their antioxidation activity. 
     Construction of benzopyran library having a wide variety of derivatives by means of the technology of combinatorial chemical synthesis is very useful in exploiting hit or lead compounds at the initial stage for developing new drugs. 
     In particular, it is very important that the library of small organic molecular compounds, wherein various substituents can be introduced and Lipinsky&#39;s Rule of 5 can be largely applied, is constructed in a massive and effective manner, in view of the strategy for obtaining molecular diversity useful in screening lead compounds. 
     The combinatorial chemical synthesis has been focused as a new technology for developing novel substances. Compared to conventional methods where a single compound is synthesized by a single reaction, the technology of combinatorial chemical synthesis allows to synthesize more diverse and abundant compounds simultaneously and to automate a multi-step synthesis, so that it is considered as a highly effective process of synthesizing compounds. The introduction of combinatorial chemical synthesis makes it easier to screen and optimize biological hit and lead compounds having novel structures. 
     Since the technology of combinatorial chemical synthesis is generally carried out on a solid support, a continuous multi-step process can be automated. In addition, because the isolation and purification of products in this technology is very simple, the high throughput screening for pharmacological efficacy is also made possible. 
     Although the approach of the combinatorial chemical synthesis appears to overcome the shortcomings of conventional synthesis methods as being uneconomical and ineffective, several bottlenecks still prevents it from being applied to the field of organic synthesis. One such reason is that undesired side reactions occur because most of chemical reactions on a solid support employ excess reagents. Another reason is that the selection of reaction conditions is very restricted because solvents that can be used depend on physical properties of a solid support. In the art of combinatorial chemical synthesis on a solid support, Merrifield resin and Wang resin have been often used as a solid support. However, these supports show negligible swelling effect in a high polar solvent such as alcohol and water, thereby restricting the selection of a solvent for a reaction. Therefore, in order to synthesize diverse derivatives by use of chemical reactions on a solid support, the selection of a solid support and a reaction reagent as well as the screening of reaction conditions become essential. 
     SUMMARY OF THE INVENTION 
     The present inventors have carried out intensive researches to develop a novel process for effectively constructing benzopyran library by use of combinatorial chemical synthesis technology on a solid-phase in consideration of the usefulness of benzopyran derivative in synthesis of pharmacologically effective compounds such as an antioxidant and drugs for treating neurologic diseases, hypertension and diabetes, etc. As a result, the present inventors have succeeded in developing a novel parallel synthetic process on a solid-phase by using a combinatorial chemical synthetic method in which 4 steps are performed in a successive manner to effectively produce 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran library with higher yield in a short period of time, whereas the conventional processes performing multi-step reactions in a solution synthesize compounds of interest through steps of a reaction; treatment and purification after the reaction; and an analysis of structure of the synthesized compound per each step. 
     Accordingly, it is an object of this invention to provide novel 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives useful in synthesizing drugs. 
     Another object of this invention to provide a process for preparing 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative by use of parallel synthesis on a solid-phase exhibiting advantages such as high yield and feasibility of automation of multi-step reaction and analysis of chemical structure. 
     It is still another object of this invention to provide a use of 6-amino-2,2-diethyl-3,4,6-trisubstituted benzopyran derivatives for preventing and eating diseases or disorders induced by promotion of lipid peroxidation and accumulation of oxidized molecules. 
     DETAILED DESCRIPTION OF THE INVENTION 
     In one aspect of this invention, there is provided a 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative represented by the following formula (5): 
                 
 
wherein R 1  represents a C 1 -C 10  alkyl, aryl, benzyl or substituted benzyl, or phenethyl group; R 2  represents a C 1 -C 10  alkyl, benzyl or substituted benzyl, or phenethyl group; R 3  represents a hydrogen atom, a C 1 -C 10  alkyl group, a C 2 -C 10  alkenyl group, a C 2 -C 10  alkynyl, benzyl or substituted benzyl, naphthylmethyl group, or —C(O)R 4 ; R 4  represents a C 1 -C 10  alkyl, phenyl or substituted phenyl groups or five-or seven-membered heterocyclic ring containing a heteroatom selected from the group consisting of oxygen and sulfur, and the substituted phenyl or benzyl group may be substituted with 1-4 substituents selected from the group consisting of a halogen atom, a nitro group, a C 1 -C 10  alkoxy group and a C 1 -C 10  haloalkyl group; and R 1  is not a C 1 -C 10  alkyl group with the proviso that R 3  is a hydrogen atom.
 
     In addition, the 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative represented by the formula (5) has several chiral centers, and therefore, its optical isomers in synthesizing process can be obtained and included within the scope of the present compounds. 
     The present invention will be described in more detail hereunder. 
     The present invention provides (i) a 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative represented by the formula (5); (ii) a process according to parallel synthesis on solid-phase as one of combinatorial chemical synthesis technologies for permitting to effectively synthesize the novel benzopyran derivatives described above by use of parallel synthesis on solid-phase instead of chemical reaction in liquid-phase; and (iii) use of the novel benzopyran derivatives described above for preventing and treating diseases or disorders induced by lipid peroxidation promotion or accumulation of oxidized products. 
     The process for preparing a 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative represented by the formula (5) according to the technology of combinatorial chemical synthesis is illustrated in Scheme 1.
 
Scheme 1
                 
 
wherein R 1 , R 2  and R 3  are the same as above; and {circumflex over (p)} is a polymeric solid support selected from the group consisting of polystyrene-divinylbenzene, methacrylic acid-dimethylacrylamide and hydroxyl methacrylic acid.
 
     In the process according to the present invention, the intermediates including 2,2-dimethyl-3-hydroxy-6-alkyl amino benzopyran resin of the formula (3) and 2,2-dimethyl-3-substituted-4-alkoxy-6-alkyl amino benzopyran resin of the formula (4) also have several chiral centers, and if necessary, each optical isomer can be isolated. 
     The present process represented by the Scheme 1 comprises the following steps:
         (a) synthesizing a N-alkyl substituted carbamate resin of the formula (2) by introducing an alkyl substituent selectively to a nitrogen atom of benzopyran linked to a carbamate linker represented by the formula (1);   (b) synthesizing a 2,2-dimethyl-3-hydroxy-6-alkyl amino benzopyran resin of the formula (3) by performing epoxidation and alkoxy addition simultaneously by adding metachloroperbenzoic acid (m-CPBA) and alcohol to the compound of the formula (2); (c) synthesizing a 2,2-dimethyl-3-substituted-4-alkoxy-6-alkyl amino benzopyran derivative of the formula (4) by introducing a substituent R 3  to 3-hydroxyl group of the compound of the formula (3); and (d) synthesizing said 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative of the formula (5) by departing the compound of the formula (4) with a dichloromethane solution containing trifluoroacetic acid (TFA) or an organic solvent containing organic acid.       

     According to the findings of the present inventors, when N-alkylation and hydroxy alkoxylation are successively carried out by use of benzopyran resin having a carbamate linker on a solid support of the formula (1), the number of times for purification can be reduced to one from four in conventional reaction in a solution. Such advantage allows to synthesize a wide variety of 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives in a short period of time. 
     In the present process, the necessary steps, compositions of solvent systems and reaction conditions will be described in more detail hereunder: 
     The organic solvent showing excellent swelling effect on Wang resin or Merrifield resin is useful as solvent for the present process. 
     In step (a), dimethylsulfoxide (DMSO) or tetrahydrofuran (THF) may be used. Preferably, each of base and R 1  substituent is used in the amount of 3 equivalents, and more preferably, about 2 equivalents. As a base, lithium t-butoxide (LiOtBu) is preferred and as R 1  substituent, the halides such as alkyl halide or benzyl halide is preferred. 
     In step (b), to inhibit the occurrence of 3-chlorobenzoic acid as a by-product in oxidation, metachloroperbenzoic acid (m-CPBA) is introduced in the amount of less than 3 equivalents. In particular, it is preferred that prior to addition of m-CPBA, alcohols as alkoxy precursor is excessively added and mixed by agitating for above 15 min followed by addition of an oxidant. The reason is that an alkoxy group predominant over 3-chlorobenzoic acid makes it possible to inhibit the production of a by-product. The alcohols as alkoxy precursor refers to aliphatic alcohols, for example, includes methanol, ethanol, iso-propyl alcohol, benzyl alcohol, and amino acids having aliphatic alcohol at its side chain and protection group at its amine and carboxyl groups. 
     In step (c), the 3-hydroxy group generated is reacted with halogenated alkyls or carbonyl derivatives as electrophile to introduce R 3  group, thereby converting to 2,2-dimethyl-3-substituted form. For example, for converting to 3-alkylether form, halogenated alkyl may be used as electophile and the reaction is performed in the presence of lithium t-butoxide and a solvent of dimethylformamide (DMF). The halogenated alkyls include, but not limited to, halogenated methane, ethane, propane, iso-propane and butane, benzyl halide and substituted benzyl halide. For example, for converting to 3-ester form, carbonyl halide compound containing R 4  group may be used as electophile and the reaction is performed in the presence of base and a solvent of dichloromethane. The carbonyl derivative used includes, but not limited to, acetyl halide, t-butylacetyl halide, cyclohexanecarbonyl halide, 3,3 dimethylacryloyl halide, benzoyl halide, p-toluyl halide, 4-anisoyl chloride, 4-halobenzoyl halide, 2-thiopencarbonyl halide and 2-furoyl halide. 
     In step (d), the departure reaction is carried out using dichloromethane solution containing trifluoroacetic acid (TFA) or an organic solvent containing organic acid in order to produce 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran library of interest represented by the formula (5). 
     For elucidating the production of 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran library of the formula (5), the compound of interest departed from 2,2-dimethyl-3-substituted-4-alkoxy-6-alkyl amino benzopyran resin of the formula (4) may be purified and isolated in the final step by use of flash column chromatography having multiple columns and its structure is analyzed with NMR and/or Mass spectroscopy. The progress of reaction may be monitored with ATR-FFIR for detecting the intermediates, the resins of the formulae (1), (2), (3) and (4). 
     Furthermore, the compound of this invention can be used as an inhibitor against lipid peroxidation owing to its inhibitory potency to lipid peroxidation induced iron. Therefore, the present compound is very useful as a drug for preventing and treating several diseases or disorders elicited by promotion of lipid peroxidation and accumulation of oxidized molecules. That is, the present compound can be used as a drug for preventing and treating diseases or disorders such as cancer, arteriosclerosis, diabetes, apoplexy, dementia, Parkinson&#39;s disease and senescence that is induced by production of peroxidized lipid with cytotoxicity or destruction of cell membrane due to attack to lipid in cell membrane. 
     Therefore, in another aspect of this invention, there is provided a pharmaceutical composition for inhibiting lipid peroxidation, i.e., treating or preventing diseases induced by promotion of lipid peroxidation and accumulation of oxidized molecules, which comprises 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative or its pharmaceutically acceptable salt as an active ingredient. 
     The pharmaceutically acceptable salts of this invention may be prepared according to the conventional process known in the art, for example, by use of an inorganic acid such as hydrochloric acid, hydrogen bromide, sulfuric acid, sodium bisulfate, phosphoric acid and carbonic acid or an organic acid such as formic acid, acetic acid, oxalic acid, benzoic acid, citric acid, tartaric acid, gluconic acid, fumaric acid, lactobionic acid, salicylic acid and acetylsalicylic acid. In addition to this, pharmaceutically acceptable salts may be prepared in a form of metal salt with alkali metal ion such as sodium and potassium and other forms with ammonium ion. 
     Furthermore, the pharmaceutical composition of this invention may be formulated by using 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative or its pharmaceutically acceptable salt together with a pharmaceutically acceptable carrier, additive, vehicle, diluent and so on. Non-limiting examples of the formulations include, but not limited to, a solution, a suspension or an emulsion, a tablet, a capsule and troches. The pharmaceutical compositions of this invention may be administered orally or parenterally, and the parenteral administration comprises intravenous injection, subcutaneous injection and intramuscular injection. The dosage of pharmaceutical compositions of the present invention to be administered to humans can vary according to various factors such as the type of formulation, the mode of administration, age, body weight, sex, diet, sensitivities to drugs, severity of a disease and physical condition of a patient as well as the type of administration, etc. It is understood that the ordinary skilled physician will readily be able to determine and prescribe a correct dosage of the pharmaceutical compositions. In an embodiment of the present invention, a preferred dosage of the present composition is 0.01-1000 mg/day with reference to the application to an adult patient with a body weight of 70 kg. The present pharmaceutical composition may be administered at regular time intervals according to the instruction of a physician ranging from one to several times per day. 
     The following specific examples are intended to be illustrative of the invention and should not be construed as limiting the scope of the invention. 
     EXAMPLE I 
     Synthesis of 2,2-dimethyl-3-(4-fluorobenzyl)ether-4-methoxy-6-(4-methoxybenzyl)amino Benzopyran 
     (I-1) N-4-methoxybenzylation of Olefin Resin 1
                 
 
     Carbamate resin having a benzopyran structure of the formula (1) (200.00 mg, 0.11 mmol) was added to dimethylsulfoxide (DMSO; 3 ml) and agitated for 10 min at room temperature, followed by adding lithium t-butoxide (LiOtBu)(0.33 ml, 0.33 μmmol) in 1 M of tetrahydrofuran (THF) and agitating for 20 min at the same temperature. To the mixture, 4-methoxybenzylchloride (4-MeOBnCl; 0.045 ml, 0.33 mmol) was added and agitated to proceed with a reaction for 15 hr at 35 C. Upon completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding N4-methoxybenzyl-substituted carbamate resin of the formula (2a) as a light brown solid (ATR-FTIR analysis result: N-4-methoxy benzylation carbamate, 1700 cm −1 ).
 
(I-2) Addition of Hydroxy Methoxy to N-methoxybenzyl-substituted Olefin Resin (2a) 
                 
 
     N-4-methoxybenzyl-substituted carbamate resin (200 mg, 0.11 mmol) of the formula (2a) was added to the mixed solution of dichloromethane (3 ml) and methanol (3 ml) and agitated for 30 min, after which metachloroperbenzoic acid (m-CPBA, 81 mg, 0.55 mmol) was added at room temperature and agitated to proceed with a reaction for 12 hr at room temperature. After the completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MEOH, thereby yielding the resin of the formula (3a-1) as a light yellow solid.
 
(I-3) Etherification of N-4-methoxybenzyl-substituted Hydroxy Methoxy Resin (3a-1) 
                 
 
     2,2-dimethyl-3-hydroxy-6-(4-methoxybenzyl)-ammo benzopyran resin (200.0 mg, 0.11 mmol) linked to a carbamate linker represented by the formula (3a-1) was added to a solution of dimethylformamide (3 ml) and agitated for 30 min at room temperature, followed by addition of lithium t-butoxide (LiOtBu)(1.1 ml, 1.1 mmol) in 1 M of tetrahydrofuran (THF) and agitation for 30 min at room temperature. To the mixture, 4-fluorobenzylbromide (0.274 ml, 0.22 mmol) was added and agitated to proceed with a reaction for 6 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (4a-1) as a light brown solid.
 
(I-4) Departure Reaction of 2,2-dimethyl-3(4-fluorobenzyl)ether-4-methoxy-6-(4-methoxybenzyl)amino Benzopyran 
                 
 
     The resin (200 mg) of the formula (4a-1) was added to a solution of dichloromethane (5 ml) and agitated, followed by addition of trifluoroacetic acid (TFA, 1 ml) and agitation for 3 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and the filtrate was washed repeatedly with dichloromethane and methyl alcohol. The filtrates were combined and concentrated. To the concentrates, ethylacetate (3 ml) was added, filtered thorough strong anion exchange resin (SAX) and washed repeatedly with ethylacetate to remove residual TFA. Following concentration of the filtrate under reduced pressure, the concentrate was purified with silica gel column chromatography in the presence of hexane/ethylacetate (4/1, v/v), thereby yielding the compound of the formula (5-338) as a light-yellow oil (22.75 mg, yield=45.8%; 4 step overall yield from resin 1; loading capacity of resin 1=0.55 mmol/g):  1 H NMR(200 MHz, CDCl 3 ) δ(PPM) 6.95-7.40 (m, 8H), 6.75 (m, 3H), 4.83(d, 1H, J=11.4 Hz), 4.65 (d, 1H, J=11.4 Hz), 4.15 (s, 2H), 4.28 (d, J=7.3 Hz), 3.67 (s, 3H), 3.53 (d, 1H, J=7.3 Hz), 3.50 (s, 3H), 1.40 (s, 3H), 1.23 (s, 3H); Mass, m/z: 451.54. 
     The 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives synthesized according to the method of parallel synthesis on the solid-phase as Example I are summarized in Table 1. 
     In construction of the library in Table I, the following precursors were employed to prepare combinations of each substituent: for example, R 1  precursor includes CH 3 I, C 2 H 5 I, tBuI, 4-BuI, 4-F—C 4 H 9 I, 4-Me-C 4 H 9 I, 2-CH 3 -C 4 H 9 I, 3-Cl—C 4 H 9 I, 4-tBu-C 4 H 9 I and 3-F—C 4 H 9 I; R 2  precursor includes CH 3 OH, C 2 H 5 OH, iPrOH, tBuOH, C 4 H 9 OH, 2-Ph-EtOH and 2-cyclohexyl-EtOH; R 3  precursor includes C 4 H 9 Br, 4-F—C 4 H 9 Br, 4-tBu-C 4 H 9 Br, 3-F—C 4 H 9 Br, 2-CH 3 -C 4 H 9 Br, 2-Cl—C 4 H 9 Br, 3-Cl—C 4 H 9 Br, 4-CH 3 -C 4 H 9 Br, 4-Br-2-F—C 4 H 9 Br, β-CH 3 Br—NaOH, 3,5-CF 3 -C 4 H 9 Br, CH 3 OH, C 5 H 11 I, 1-bromo-2-butene, 3-bromopropene and 3-bromoprophine (Propargyl Br). 
     
       
         
           
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                   
                 Compound No. 
                 NMR/MS Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.42˜7.29(m, 5H), 6.70˜6.50(m, 3H), 4.93(d, 1H, J=11.6 Hz), 4.73(1H, d, J=11.6 Hz), 4.45(d, 1H, J=7.3 Hz), 3.63(d, 1H, J=7.3 Hz), 3.51(s, 3H), 3.63(s, 3H), 1.42(s, 3H), 1.24(s, 3H); MS, m/z: 327.43 
               
               
                 5-1 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.39˜7.32(m, 2H), 7.08˜6.99(m, 2H), 6.69˜6.52(m, 3H), 4.87(d, 1H, J=11.5 Hz), 4.68(d, 1H, J=11.3 Hz), 4.43(d, 1H, J=7.2 Hz), 4.60(s, 1H, J=7.2 Hz), 3.49(s, 3H), 2.81 (s, 3H), 1.40(s, 3H), 1.25(s, 3H); MS, m/z: 345.42 
               
               
                 5-2 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.16(m, 4H), 6.74˜6.52(m, 3H), 4.88(d, 1H, J=11.4 Hz), 4.70(d, 1H, J=11.4 Hz), 4.42(d, 1H, J=7.4 Hz), 3.61(d, 1H, J=7.3 Hz), 3.51(s, 3H), 2.82(s, 3H), 1.42(s, 3H), 1.32(m, 9H), 1.24(s, 3H); MS, m/z: 383.54 
               
               
                 5-3 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ .31(m, 1H), 7.16˜7.0(m, 2H), 6.99(m, 1H), 6.70˜6.50(m, 3H), 4.93(d, 1H, J=11.9 Hz), 4.72(d, 1H, J=11.8 Hz), 4.46(d, 1H, J=7.4 Hz), 3.62(d, 1H, J=7.5 Hz), 3.50(s, 3H), 2.81 (s, 3H), 1.43(s, 3H), 1.24(s, 3H); MS, m/z: 345.42 
               
               
                 5-4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ .31(m, 1H), 7.16˜7.0(m, 2H), 6.99(m, 1H), 6.70˜6.50(m, 3H), 4.93(d, 1H, J=11.9 Hz), 4.72(d, 1H, J=11.8 Hz), 4.46(d, 1H, J=7.4 Hz), 3.62(d, 1H, J=7.5 Hz), 3.50(s, 3H), 2.81 (s, 3H), 1.43(s, 3H), 1.24(s, 3H); MS, m/z: 345.42 
               
               
                 5-5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.55(m, 1H), 7.39˜7.22(m, 3H), 6.71˜6.50(m, 3H), 5.03(d, 1H, J=12.8 Hz), 4.82(d, 1H, J=12.8 Hz), 4.47(d, 1H, J=7.3 Hz), 3.68(d, 1H, J=7.3 Hz), 3.52(s, 3H), 2.81 (s, 3H), 1.43(s, 3H), 1.27(s, 3H); MS, m/z: 361.87 
               
               
                 5-6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41(m, 1H), 7.28(m, 3H), 6.70˜6.50(m, 3H), 4.90(d, 1H, J=12.0 Hz), 4.70(d, 1H, J=12.0 Hz), 4.46(d, 1H, J=7.5 Hz), 3.61(d, 1H, J=7.5 Hz), 3.50(s, 3H), 2.81 (s, 3H), 1.43(s, 3H), 1.24(s, 3H); MS, m/z: 361.87 
               
               
                 5-7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.28(d, 2H, J=7.9 Hz), 7.16(d, 2H, J=7.9 Hz), 6.74˜6.49(m, 3H), 4.87(d, 1H, J=11.2 Hz), 4.68(d, 1h, J=11.2 Hz), 4.42(d, 1H, J=7.4 Hz), 4.34(d, 1H, J=7.5 Hz), 3.51(s, 3H), 2.81(s, 3H), 2.81(s, 3H), 1.40(s, 3H), 1.23(s, 3H); MS, m/z: 341.45 
               
               
                 5-8 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.40˜7.22(m, 3H), 6.69˜6.50(m, 3H), 4.90(d, 1H, J=11.8 Hz), 4.73(d, 1H, 1=11.8 Hz), 4.42(d, 1H, J=7.5 Hz), 3.61(d, 1H, J=7.5 Hz), 3.51(s, 3H), 2.81(s, 3H), 1.40(s, 3H), 1.21 (s, 3H); MS, m/z: 424.31 
               
               
                 5-9 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.85(m, 4H), 7.50(m, 3H), 6.71˜6.51 (m, 3H), 5.08(d, 1H, J=11.6 Hz), 4.89(d, 1H, J=11.6 Hz), 4.49(d, 1H, J=7.2 Hz), 3.69(d, 1H, J=7.2 Hz), 3.51(s, 3H), 2.82(s, 3H), 1.43(s. 3H), 1.27(s, 3H) ; MS, m/z: 377.49 
               
               
                 5-10 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 355.48 
               
               
                 5-11 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 251.33 
               
               
                 5-12 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 307.44 
               
               
                 5-13 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 291.39 
               
               
                 5-14 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 277.37 
               
               
                 5-15 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 275.35 
               
               
                 5-16 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.27(m, 5H), 6.69˜6.52(m, 3H), 4.92(d, 1H, J=11.4H), 4.72(d, 1H, J=11.4 Hz), 4.47(d, 1H, J=7.6 Hz), 3.76(q, 2H, J=6.9 Hz), 3.61(d, 1H, J=7.6 Hz), 2.81(s, 3H), 1.41(s, 3H), 1.29(m, 3H), 1.24(s, 3H); MS, m/z: 341.45 
               
               
                 5-17 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.40˜7.31(m, 2H), 7.10˜6.69(m, 2H), 6.67˜6.53(m, 3H), 4.87(d, 1H, J=11.5 Hz), 4.68(d, 1H, J=11.5 Hz), 4.46(d, 1H, J=7.4 Hz), 3.75(q, 2H, J=7.0 Hz), 3.59(d, 1H, J=5.4 Hz), 2.82(s, 3H), 1.40(s, 3H), 1.28(t, 3H, J=J=7.0 Hz), 1.22(s, 3H); MS, m/z: 359.44 
               
               
                 5-18 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.29(m, 4H), 6.69˜6.56(m, 3H), 4.87(d, 1H, J=11.1 Hz), 4.69(s, 1H, J=11.1 Hz), 4.45(d, 1H, J=7.3 Hz), 3.75(m, 2H), 3.60(d, 1H, J=7.5 Hz), 1.41(s, 3H), 1.32(s, 9H), 1.32(m, 3H), 1.24(s, 3H); MS, m/z: 397.56 
               
               
                 5-19 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.37˜7.26(m, 1H), 7.15˜6.99(m, 3H), 6.70˜6.62(m, 3H), 4.91(d, 1H, J=11.8 Hz), 4.71(d, 1H, J=11.8 Hz), 4.48(d, 1H, J=7.5 Hz), 3.76(q, 2H, J=6.9 Hz), 3.60(d, 1H, J=7.5 Hz), 2.82(s, 3H), 1.42(s, 3H), 1.28(m, 3H), 1.25(s, 3H); MS, m/z: 359.44 
               
               
                 5-20 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.39(m, 1H), 7.26˜7.19(m, 3H), 6.69˜6.58(m, 3H), 4.94(d, 1H, J=11.7 Hz), 4.70(d, 1H, J=11.7 Hz), 4.48(d, 1H, J=7.7 Hz), 3.74(q, 2H, J=7.1 Hz), 3.63(d, 1H, J=7.7 Hz), 2.82(s, 3H), 2.36(s, 3H), 1.39(s, 3H), 1.27(m, 3H), 1.23(s, 3H); MS, m/z: 355.48 
               
               
                 5-21 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.55(m, 1H), 7.39˜7.18(m, 3H), 6.70˜6.52(m, 3H), 5.04(d, 1H, J12.7 Hz), 4.81(d, 1H, J=12.7 Hz), 4.50(d, 1H, J=7.5 Hz), 3.77(q, 2H, J=7.0 Hz), 3.67(d, 1H, J=7.6 Hz), 2.81 (s, 3H), 1.42(s, 3H), 1.27(m, 3H), 1.26(s, 3H) MS, m/z: 375.90 
               
               
                 5-22 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.38˜7.17(m, 4H), 6.72˜6.50(m, 3H), 4.90(d, 1H, J=12.1 Hz), 4.69(d, 1H, J=12.1 Hz), 4.48(d, 1H, J=7.6 Hz), 3.75(q, 2H, J=7.0 Hz), 3.60(d, 1H, J=7.6 Hz), 1.42(s, 3H), 1.28(s, 3H), 1.28(t, 3H, J=7.0 Hz), 1.24(s, 3H); MS, m/z: 375.90 
               
               
                 5-23 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.36˜7.06(m, 4H), 6.68˜6.49(mm, 3H), 4.8(d, 1H, J=11.4 Hz), 4.67(d, 1H, J=11.4 Hz), 4.45(d, 1H, J=7.4 Hz), 3.78(m, 2H), 3.59(d, 1H, J=7.4 Hz), 2.81(s, 1H), 2.35(s, 3H), 1.40(s, 3H), 1.28(m, 3H), 1.22(s, 3H); MS, m/z: 355.48 
               
               
                 5-24 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.39˜7.23(m, 3H), 6.75˜6.49(m, 3H), 4.91 (d, 1H, J=12.5 Hz), 4.72(d, 1H, J=12.5 Hz), 4.46(d, 1H, J=7.4 Hz), 3.7(q, 2H, J=7.0 Hz), 3.60(d, 1H, J=7.4 Hz), 2.80(s, 3H), 1.40(s, 3H), 1.28(t, 3H, J=7.0 Hz), 1.21 (s, 3H); MS, m/z: 438.34 
               
               
                 5-25 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.86˜7.82(m, 4H), 7.54˜7.46(m, 3H), 6.69˜6.50(m, 3H), 5.07(d, 1H, J=12.0 Hz), 4.8(d, 1H, J=12.0 Hz), 4.51(d, 1H, J=7.5 Hz), 3.76(q, 2H, J=6.9 Hz), 3.67(d, 1H, J=7.5 Hz), 2.81(s, 3H), 1.429(s, 3H), 1.28(m, 3H), 1.27(s, 3H); MS, m/z: 391.51 
               
               
                 5-26 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.83(m, 3H), 6.72˜6.50(m, 3H), 5.06(d, 1H, J=12.4 Hz), 4.85(d, 1H, J=12.4 Hz), 4.54(d, 1H, J=7.9 Hz), 3.79˜3.65(m, 2H), 3.65(d, 1H, J=7.9 Hz), 2.81(s, 3H), 1.44(s, 3H), 1.26(m, 3H), 1.26(s, 3H); MS, m/z: 477.45 
               
               
                 5-27 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 6.67˜6.48(m, 3H), 4.36(d, 1H, J=7.4 Hz), 3.80(q, 2H, J=6.9 Hz), 3.32(d, 1H, J=7.4 Hz), 2.80(s, 3H), 1.42(s, 3H), 1.31 (t, 3H, J=6.9 Hz), 1.20(s, 3H); MS, m/z: 265.36 
               
               
                 5-28 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 6.67˜6.50(m, 3H), 4.36(d, 1H, J=7.6 Hz), 3.85˜3.75(m, 3H), 3.62˜3.58(m, 1H), 3.39(d, 1H, J=7.6 Hz), 2.80(s, 3H), 1.72˜1.51(m, 2H), 1.41(s, 3H), 1.33(m, 2H), 1.29(m, 3H), 1.20(s, 3H), 0.91 (m, 3H); MS, m/z: 321.46 
               
               
                 5-29 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 6.67˜6.48(m, 3H), 5.80˜5.58(m, 2H), 4.44˜4.08(m, 3H), 3.87˜3.74(m, 2H), 3.48(d, 1H, J=7.5 Hz), 2.80(s, 3H), 1.72(d, 3H, J=4.9 Hz), 1.41(s, 3H), 1.30(m, 3H), 1.21(s, 3H); MS, m/z: 305.42 
               
               
                 5-30 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 6.75˜6.49(m, 3H), 6.04˜5.87(m, 1H), 5.29(dd, 1H, 1=17.1 Hz, J=1.6 Hz), 5.18(dd, 1H, J=10.2 Hz, J=1.6 Hz), 4.40(d, 1H, J=7.7 Hz), 4.35˜4.14(m, 2H), 3.80(q, 2H, J=7.1 Hz), 3.49(d, 1H, 1=7.7 Hz), 2.81(s, 3H), 1.41(s, 3H), 1.30(t, 3H, J=7.1˜Hz), 1.22(s, 3H); MS, m/z: 291.39 
               
               
                 5-31 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 6.87˜6.49(m, 3H), 4.61˜4.35(m, 3H), 3.83˜3.30(m, 3H), 2.80(s, 3H), 2.46(m, 1H), 1.44(s, 3H), 1.29(m, 3H), 1.22(s, 3H); MS, m/z: 289.38 
               
               
                 5-32 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 355.48 
               
               
                 5-33 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 373.47 
               
               
                 5-34 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 411.59 
               
               
                 5-35 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 373.47 
               
               
                 5-36 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 369.51 
               
               
                 5-37 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 389.93 
               
               
                 5-38 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 389.93 
               
               
                 5-39 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 369.51 
               
               
                 5-40 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.37 
               
               
                 5-41 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 405.54 
               
               
                 5-42 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 491.48 
               
               
                 5-43 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 279.38 
               
               
                 5-44 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 335.49 
               
               
                 5-45 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 319.45 
               
               
                 5-46 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 305.42 
               
               
                 5-47 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 303.40 
               
               
                 5-48 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.26(m, 5H), 6.68˜6.49(m, 3H), 4.91(d, 1H, J=11.6 Hz), 4.71(d, 1H, J=11.6 Hz), 4.45(d, 1H, J=7.3 Hz), 3.71(m, 2H), 3.61(d, 1H, J=7.3 Hz), 2.81(s, 3H), 1.60(m, 2H), 1.45(m, 2H), 1.40(s, 3H), 1.24(s, 3H), 0.93(t, 3H, J=7.2 Hz); MS, m/z: 369.51 
               
               
                 5-49 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.38˜7.26(m, 2H), 7.08˜6.99(m, 2H), 6.68˜6.50(m, 3H), 4.86(d, 1H, J=11.6 Hz), 4.67(d, 1H, r=1.6 Hz), 4.45(d, 1H, J=7.3 Hz), 3.67(m, 2H), 3.59(d, 1H, J=7.3 Hz), 2.81(s, 3H), 1.62(m, 2H), 1.41(m, 2H), 1.39(s, 3H), 1.23(s, 3H), 0.93(t, 3H, J=7.2 Hz); MS, m/z: 387.50 
               
               
                 5-50 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.26(m, 4H), 6.76˜6.48(m, 3H), 4.86(d, 1H, J=11.0 Hz), 4.68(d, 1H, J=11.0 Hz), 4.44(d, 1H, J=7.4 Hz), 3.70(m, 2H), 3.60(d, 1H, J=7.4 Hz), 2.81(s, 3H), 1.61(m, 2H), 1.43(m, 2H), 1.41(s, 3H), 1.32(m, 9H), 1.24(s, 3H), 0.94(m, 3H); MS, m/z: 425.62 
               
               
                 5-51 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.37˜7.29(m, 1H), 7.15˜6.99(m, 3H), 6.69˜6.49(m, 3H), 4.91(d, 1H, J=11.9 Hz), 4.71(d, 1H, J=12.0 Hz), 4.48(d, 1H, J=7.4 Hz), 3.69(t, 2H, J=6.5 Hz), 3.60(d, 1H, J=7.4 Hz), 2.81(s, 3H), 1.61((m, 2H), 1.45(m, 2H), 1.41(s, 3H), 1.24(s, 3H), 0.93(t, 3H, J=7.2 Hz); MS, m/z: 387.50 
               
               
                 5-52 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.38(m, 1H), 7.23˜7.19(m, 3H), 6.68˜6.49(m, 3H), 4.93(d, 1H, J=11.7 Hz), 4.69(d, 1H, J=11.7 Hz), 4.47(d, 1H, J=7.3 Hz), 3.71˜3.61 (m, 3H), 2.81(s, 3H), 2.36(s, 3H), 1.62(m, 2H), 1.42m, 2H), 1.38(s, 3H), 1.24(s, 3H), 0.92(t, 3H, J=7.2 Hz); MS, m/z: 383.54 
               
               
                 5-53 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 403.95 
               
               
                 5-54 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.38˜7.24(m, 4H), 6.69˜6.49(m, 3H), 4.89(d, 1H, J=11.7 Hz), 4.69(d, 1H, J=11.7 Hz), 4.47(d, 1H, J=7.4 Hz), 3.68(t, 2H, J=6.4 Hz), 3.59(d, 1H, J=7.4 Hz), 2.81(s, 3H), 1.63(m, 2H), 1.45(m, 2H), 1.41(s, 3H), 1.25(s, 3H), 0.93(t, 3H, J=7.2 Hz); MS, m/z: 403.95 
               
               
                 5-55 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z 383.54 
               
               
                 5-56 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.34˜7.21(m, 3H), 6.69˜6.50(m, 3H), 4.90(d, 1H, J=11.8 Hz), 4.71 (d, 1H, J=11.8 Hz), 4.44(d, 1H, J=7.2 Hz), 3.73˜3.67(m, 2H), 3.60(d, 1H, J=7.2 Hz), 2.81(s, 3H), 1.60(m, 2H), 1.43(m, 2H), 1.39(m, 3H), 1.22(m, 3H), 0.93(t, 3H, J=7.2 Hz); MS, m/z: 466.39 
               
               
                 5-57 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 419.57 
               
               
                 5-58 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 505.51 
               
               
                 5-59 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 293.41 
               
               
                 5-60 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 349.52 
               
               
                 5-61 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 333.47 
               
               
                 5-62 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 6.67˜6.48(m, 3H), 6.07˜5.87(m, 1H), 5.30(dd, 1H, J=17.1 Hz, J=1.6 Hz), 5.18(dd, 1H, J=10.1 Hz, J=1.6 Hz), 4.39(d, 1H, J=7.5 Hz), 4.35(m, 1H), 4.23(m, 1H), 3.75(m, 2H), 3.59(d, 1H, J=7.5 Hz), 2.80(s, 3H), 1.62(m, 2H), 1.43(m, 2H), 1.41(s, 3H), 1.23(s, 3H), 0.95(t, 3H, J= 7.2 Hz); MS, m/z 319.45 
               
               
                 5-63 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 6.84(m, 3H), 4.45(d, 2H, J=2.5 Hz), 4.45(m, 1H), 3.72(m, 3H), 2.80(s, 3H), 2.45(t, 1H, J=2.5 Hz), 1.62(m, 2H), 1.47(m, 2H), 1.44(s, 3H), 1.23(s, 3H), 0.95(t, 3H, J=7.2 Hz); MS, m/z: 317.43 
               
               
                 5-64 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.42˜7.29(m, 5H), 6.70˜6.49(m, 3H), 4.91 (d, 1H, J=11.4 Hz), 4.83˜4.68(m, 3H), 3.71(d, 1H J=7.1 Hz), 2.74(s, 3H), 1.44(s, 3H), 1.27(s, 3H); MS, m/z: 403.53 
               
               
                 5-65 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 421.52 
               
               
                 5-66 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.42˜7.14(m, 9H), 6.72˜6.51(m, 3H), 4.87(d, 1H, J=11.2 Hz), 4.83˜4.67(m, 3H), 4.63(d, 1H, J=7.0 Hz), 3.70(d, 1H, J=7.0 Hz), 2.74(s, 3H), 1.45(s, 3H), 1.33˜1.29(m, 9H), 1.27(s, 3H); MS, m/z: 459.63 
               
               
                 5-67 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.25(m, 5H), 7.12˜6.71(m, 4H), 6.68(d, 1H, J=8.1 Hz), 6.55˜6.49(m, 2H), 4.90(d, 1H, J=12.0 Hz), 4.85˜4.64(m, 4H), 3.70(d, 1H, J=7.3 Hz), 2.75(s, 3H), 1.45(s, 3H), 1.28(s, 3H); MS, m/z: 359.44 
               
               
                 5-68 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.40˜7.28(m, 5H), 7.24˜7.17(m, 4H), 6.68(d, 1H, J=8.2 Hz), 6.55˜6.49(m, 2H), 4.93(d, 1H, J=11.6 Hz), 4.88˜4.63(m, 4H), 3.74(d, 1H, J=7.1 Hz), 2.75(s, 3H), 2.32(s, 3H), 1.42(s, 3H), 1.27(s, 3H) MS, m/z: 417.55 
               
               
                 5-69 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.56˜7.20(m, 9H), 6.71˜6.49(m, 3H), 5.04(d, 1H, J=12.6 Hz), 4.98˜4.669m, 4H), 3.78(d, 1H, J=7.1 Hz), 2.75(s, 3H), 1.45(s, 3H), 1.30(s, 3H); MS, m/z: 437.97 
               
               
                 5-70 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.39˜7.21(m, 9H), 6.71˜6.49(m, 3H), 4.88(d, 1H, J=12.0 Hz), 4.81˜4.64(m, 4H), 3.70(d, 1H, J=7.4 Hz), 2.75(s, 3H), 1.45(s, 3H), 1.28(s, 3H); MS, m/z: 437.97 
               
               
                 5-71 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.39˜7.06(m, 9H), 6.85˜6.51(m, 3H), 4.86(d, 1H, J=11.8 Hz), 4.77˜4.34(m, 4H), 3.69(d, 1H, J=7.1 Hz), 2.74(s, 3H), 2.35(s, 3H), 1.43(s, 3H), 1.26(s, 3H); MS, m/z: 417.55 
               
               
                 5-72 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.40˜7.15(m, 8H), 6.75˜6.48(m, 3H), 4.88(d, 1H, J=12.0 Hz), 4.83˜4.61(m, 4H), 3.70(d, 1H, J=7.3 Hz), 2.74(s, 3H), 1.43(s, 3H), 1.24(s, 3H); MS, m/z: 500.41 
               
               
                 5-73 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.85˜7.81(m, 4H), 7.79˜7.40(m, 3H), 7.40˜7.219m, 5H), 6.71˜6.50(m, 3H), 5.05(d, 1H, J=11.7 Hz), 4.89(d, 1H, J=11.7 Hz), 4.84˜4.68(m, 2H), 4.68(d, 1H, J=7.2 Hz), 3.77(d, 1H, J=7.2 Hz), 2.75s, 3H), 1.50(s, 3H), 1.30(s, 3H); MS, m/z: 453.59 
               
               
                 5-74 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-75 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 327.43 
               
               
                 5-76 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.54 
               
               
                 5-77 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.46˜7.29(m, 5H), 6.68˜6.46(m, 3H), 5.78˜5.63(m, 2H), 4.89˜4.72(m, 2H), 4.56(d, 1H, J=7.1 Hz), 4.45˜4.10(m, 2H), 3.59(d, 1H, J=7.1 Hz), 2.73(s, 3H), 1.72(m, 3H), 1.44(s, 3H), 1.25(s, 3H); MS, m/z: 357.49 
               
               
                 5-78 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.47˜7.26(m, 5H), 7.18˜6.72(m, 3H), 6.05˜5.86(m, 1H), 5.29(dd, 1H, J=17.1 Hz, J=1.4 Hz), 5.19(dd, 1H, J=10.4 Hz, J=1.4 Hz), 4.82(m, 2H), 4.55˜4.12(m, 3H), 3.56(d, 1H, J=7.1 Hz), 2.81(s, 3H), 1.44(s, 3H), 1.28(s, 3H); MS, m/z: 353.47 
               
               
                 5-79 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.46˜7.30(m, 5H), 6.70˜6.48(m, 3H), 4.78(s, 2H), 4.62(d, 1H, J=7.1 Hz), 4.45(d, 1H, J=2.5 Hz), 4.83(d, 1H, J=6.9 Hz), 2.73(s, 3H), 2.47(t, 1H, J=2.4 Hz), 1.47(s, 3H), 1.26(s, 3H); MS, m/z: 351.45 
               
               
                 5-80 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 417.55 
               
               
                 5-81 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.54 
               
               
                 5-82 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-83 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.54 
               
               
                 5-84 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-85 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.00 
               
               
                 5-86 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.00 
               
               
                 5-87 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-88 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 514.44 
               
               
                 5-89 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 467.61 
               
               
                 5-90 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 553.55 
               
               
                 5-91 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 341.45 
               
               
                 5-92 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 397.56 
               
               
                 5-93 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 381.52 
               
               
                 5-94 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 367.49 
               
               
                 5-95 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 365.48 
               
               
                 5-96 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 423.60 
               
               
                 5-97 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 441 59 
               
               
                 5-98 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 479.71 
               
               
                 5-99 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 441.59 
               
               
                 5-100 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 437.63 
               
               
                 5-101 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 458.05 
               
               
                 5-102 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 458.05 
               
               
                 5-103 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 437.63 
               
               
                 5-104 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 506.46 
               
               
                 5-105 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-106 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 559.60 
               
               
                 5-107 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 347.50 
               
               
                 5-108 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 403.61 
               
               
                 5-109 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 387.57 
               
               
                 5-110 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 373.54 
               
               
                 5-111 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 371.52 
               
               
                 5-112 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.26(m, 5H), 6.73˜6.59(m, 3H), 4.92(d, 1H, J=11.5 Hz), 4.72(d, 1H, J=11.5 Hz), 4.42(d, 1H, J=7.3 Hz), 3.50(s, 3H), 3.14(q, 2H, J=7.1Hz), 1.41(s, 3H), 1.30˜1.20(m, 6H); MS, m/z: 341.45 
               
               
                 5-113 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.39˜7.32(m, 2H), 7.26˜6.99(m, 2H), 6.85(s, 1H), 6.71 (m, 2H), 4.86(d, 1H, J=11.3 Hz), 4.87(d, 1H, J=11.3 Hz), 4.40(d, 1H, J=7.3 Hz), 3.58(d, 1H, J=7.3 Hz), 3.51(s, 3H), 3.15(q, 2H, J=7.1 Hz), 1.40(s, 3H), 1.29˜1.20(m, 6H); MS, m/z 359.44 
               
               
                 5-114 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.15(m, 4H), 6.99˜6.68(m, 3H), 4.86(d, 1H, J=11.2 Hz), 4.68(d, 1H, J=11.2 Hz), 3.58(d, 1H, J=7.2 Hz), 3.53(s, 3H). 3.18(q, 2H, J=7.1 Hz), 1.41(s, 3H), 1.32˜1.13(m, 15H); MS, m/z: 397.56 
               
               
                 5-115 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.37˜6.99(m, 6H), 6.74(d, 1H, J=8.7 Hz), 4.90(d, 1H, J=12.0 Hz), 4.69(d, 1H, J=12.0 Hz), 4.37(d, 1H, J=.7 Hz), 3.57(m, 1H), 3.56(s, 3H), 3.22(q, 2H, J=7.1 Hz), 1.42(s, 3H), 1.38˜1.21(m, 6H); MS, m/z: 359.44 
               
               
                 5-116 
               
               
                                   
 5-117 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.40˜7.14(m, h), 6.78˜6.67(m, 3H), 4.92(d, 1H, J=11.7 Hz), 4.70(d, 1H, J=11.7 Hz), 4.41(d, 1H, J=7.4 Hz), 3.63(d, 1H, J=7.3 Hz), 3.50(s, 3H), 3,14(q, 2H, J=7.2 Hz), 2.37(s, 3H), 1.39(s, 3H), 1.28˜1.17(m, 6H), 7.55˜7.23(m, 4H), 7.06(s, 1H), 6.94˜6.88(m, 1H), 6.73(d, 1H, J=8.7 Hz), 5.00(d, 1H, J=12.5 Hz), 4.80(d, 1H, J=12.5 Hz),  
               
               
                 #4.40(d, 1H,, J=7.3 Hz), 3.64(d, 1H, J=7.3 Hz), 3.56(s, 3H), 3.20(q, 2H, J=7.1 Hz), 1.42(s, 3H), 1.32˜1.17(m, 6H); MS, m/z: 355.48 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 375.90 
               
               
                 5-118 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.38˜7.25(m, 4H), 6.73˜6.59(m, 3H), 4.90(d, 1H, J=11.9 Hz), 4.69(d, 1H, J=11.9 Hz), 4.44(d, 1H, J=7.4 Hz), 3.60(d, 1H, J=7.4 Hz), 3.50(s, 3H), 3.14(q, 2H, J=7.1 Hz), 1.42(s, 3H), 1.28˜1.21(m, 6H); MS, m/z: 375.90 
               
               
                 5-119 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.36˜7.02(m, 5H), 6.94˜6.88(m, 2H), 6.72(d, 1H, J=8.9 Hz), 4.84(d, 1H, J=11.9 Hz), 4.65(d, 1H, J=11.9 Hz), 4.35(d, 1H, J=7.3 Hz), 3.57(d, 1H, J=7.3 Hz), 3.55(s, 3H), 3.29(q, 2H, J=7.1 Hz), 2.35(s, 3H), 1.39(s, 3H), 1.30˜1.15(m, 6H); MS, m/z: 355.48 
               
               
                 5-120 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.39˜7.23(m, 3H), 6.73˜6.58(m, 3H), 4.89(d, 1H, J=11.8 Hz), 4.72(d, 1H, J=11.8 Hz), 4.41(d, 1H, J=7.3 Hz), 4.15(d, 1H, J=7.3 Hz), 3.51(s, 3H), 3.13(q, 2H, J=7.1 Hz), 1.40(s, 3H), 1.29˜1.20(m, 6H); MS,  m/z: 438.34 
               
               
                 5-121 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.86˜7.81(m, 4H), 7.53˜7.46(m, 3H), 7.01(d, 1H, J=3.2 Hz), 6.84(m, 1H), 6.72(d, 1H, J=8.7 Hz), 5.05(d, 1H, J=11.6 Hz), 4.87(d, 1H, J=11.6 Hz), 4.43(d, 1H, J=7.2 Hz), 3.65(d, 1H, J=7.2 Hz), 3.55(s, 3H), 4.19(q, 2H, J=7.2 Hz), 2.04(s, 3H), 1.41(s, 3H), 1.29˜1.22(m, 6H); MS, m/z: 391.51 
               
               
                 5-122 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.62(d, 2H, J=8.1 Hz), 7.50(d, 2H, J=8.1 Hz), 6.70˜6.54(m, 3H), 5.00(d, 1H, J=12.1 Hz), 5.78(d, 1H, J=12.1 Hz), 4.47(d, 1H, J=7.6 Hz), 3.63(d, 1H, =7.6 Hz), 3.48(s, 3H), 3.13(q, 2H, J=7.1 Hz), 1.43(s, 3H), 1.28˜1.21(m, 6H); MS, m/z: 409.45 
               
               
                 5-123 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 6.68˜6.53(m, 3H), 4.32(d, 1H, J=7.3 Hz), 3.61(s, 3H), 3.55(s, 3H), 3.34(d, 1H, J=7.3 Hz), 3.12(q, 2H, J=7.1 Hz), 1.41(s, 3H), 1.27˜1.20(m, 6H); MS, m/z: 265.36 
               
               
                 5-124 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 6.92˜6.66(m, 3H), 4.28(d, 1H, J=7.3 Hz), 3.88˜3.74(m, 2H), 3.70˜3.53(m, 2H), 3.61 (s, 3H), 3.39(d, 1H, J=7.3 Hz), 3.16(q, 2H, J=7.2 Hz), 1.80˜1.10(m, 13H), 0.91(m, 3H); MS, m/z: 321.46 
               
               
                 5-125 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 6.91˜6.74(m, 2H), 6.68(d, 1H, J=8.4 Hz), 5.73˜5.63(m, 2H), 4.33˜4.23(m, 2H), 4.16˜4.05(m, 1H), 3.56(s, 3H), 3.48(d, 1H, J=7.1 Hz), 3.16(q, 2H, J=7.1 Hz), 1.72(d, 3H, J=6.9 Hz), 1.40(s, 3H), 1.32˜1.23(m, 6H); MS, m/z: 35.42 
               
               
                 5-126 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 6.67˜6.04(m, 3H), 5.99˜5.90(m, 1H), 5.30(dd, 1H, J=17.3 Hz, J=1.5 Hz), 5.18(dd, 1H, J=10.4 Hz, J=1.5 Hz), 4.42˜4.33(m, 2H), 4.23˜4.14(m, 1H), 3.53(s, 3H), 3.52(m, 1H), 3.12(q, 2H, J=7.1 Hz), 1.41(s, 3H), 1.30˜1.20(m, 6H); MS, m/z: 291.39 
               
               
                 5-127 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 6.71˜6.58(m, 3H), 4.46(d, 2H, J=2.4 Hz), 4.41(d, 1H, J=7.1 Hz), 3.74(d, 1H, J=7.1 Hz), 3.52(s, 3H), 3.13(q, 2H, J=7.2 Hz), 2.46(t, 1H, J=2.4 Hz), 1.44(s, 3H), 1.28˜1.20(m, 6h); MS, m/z: 289.38 
               
               
                 5-128 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 355.48 
               
               
                 5-129 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 373.47 
               
               
                 5-130 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 411.59 
               
               
                 5-131 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 373.47 
               
               
                 5-132 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 369.51 
               
               
                 5-133 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 389.93 
               
               
                 5-134 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 389.93 
               
               
                 5-135 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 369.51 
               
               
                 5-136 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.37 
               
               
                 5-137 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 405.54 
               
               
                 5-138 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 423.48 
               
               
                 5-139 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 279.38 
               
               
                 5-140 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 335.49 
               
               
                 5-141 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 319.45 
               
               
                 5-142 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 305.42 
               
               
                 5-143 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 303.40 
               
               
                 5-144 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 369.51 
               
               
                 5-145 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 387.50 
               
               
                 5-146 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 425.62 
               
               
                 5-147 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 387.50 
               
               
                 5-148 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.54 
               
               
                 5-149 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 403.95 
               
               
                 5-150 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 403.95 
               
               
                 5-151 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.54 
               
               
                 5-152 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 466.39 
               
               
                 5-153 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 419.54 
               
               
                 5-154 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 505.51 
               
               
                 5-155 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 293.41 
               
               
                 5-156 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 349.52 
               
               
                 5-157 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 333.47 
               
               
                 5-158 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 319.45 
               
               
                 5-159 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 317.43 
               
               
                 5-160 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.54 
               
               
                 5-161 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 401.53 
               
               
                 5-162 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 439.64 
               
               
                 5-163 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 401.53 
               
               
                 5-164 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 397.56 
               
               
                 5-165 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 417.98 
               
               
                 5-166 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 417.98 
               
               
                 5-167 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 397.56 
               
               
                 5-168 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 480.42 
               
               
                 5-169 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 433.60 
               
               
                 5-170 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.53 
               
               
                 5-171 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 307.44 
               
               
                 5-172 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 363.55 
               
               
                 5-173 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 347.50 
               
               
                 5-174 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 333.47 
               
               
                 5-175 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 331.46 
               
               
                 5-176 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 417.55 
               
               
                 5-177 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.54 
               
               
                 5-178 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-179 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.54 
               
               
                 5-180 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-181 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.00 
               
               
                 5-182 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.00 
               
               
                 5-183 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-184 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 514.44 
               
               
                 5-185 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 467.61 
               
               
                 5-186 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 485.55 
               
               
                 5-187 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 341.45 
               
               
                 5-188 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 397.56 
               
               
                 5-189 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 381.52 
               
               
                 5-190 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 367.47 
               
               
                 5-191 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 365.48 
               
               
                 5-192 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-193 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.57 
               
               
                 5-194 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 487.693 
               
               
                 5-195 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.57 
               
               
                 5-196 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.61 
               
               
                 5-197 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 466.03 
               
               
                 5-198 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 466.03 
               
               
                 5-199 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.61 
               
               
                 5-200 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 528.47 
               
               
                 5-201 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 481.64 
               
               
                 5-202 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 567.58 
               
               
                 5-203 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 355.48 
               
               
                 5-204 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 411.59 
               
               
                 5-205 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 395.55 
               
               
                 5-206 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 381.52 
               
               
                 5-207 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 379.50 
               
               
                 5-208 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 437.633 
               
               
                 5-209 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 455.62 
               
               
                 5-210 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 493.47 
               
               
                 5-211 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 455.62 
               
               
                 5-212 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.66 
               
               
                 5-213 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 472.07 
               
               
                 5-214 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 472.07 
               
               
                 5-215 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.66 
               
               
                 5-216 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 534.51 
               
               
                 5-217 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 487.69 
               
               
                 5-218 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 873.62 
               
               
                 5-219 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 361.53 
               
               
                 5-220 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 417.64 
               
               
                 5-221 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 401.59 
               
               
                 5-222 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 387.57 
               
               
                 5-223 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 385.55 
               
               
                 5-224 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 403.53 
               
               
                 5-225 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.34˜7.10(m, 9H), 7.06˜7.03(m, 2H), 6.73(d, 1H, J=8.8 Hz), 4.82(d, 1H, J=11.4 Hz), 4.63(d, 1H, J=11.4 Hz), 4.25(d, 1H, J=6.9 Hz), 4.21(s, 3H), 3.51(d, 1H, J=6.9 Hz), 3.49(s, 3H), 1.40(s, 3H), 1.26(s, 3H); MS, m/z: 421.52˜ 
               
               
                 5-226 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.39˜7.26(m, 9H), 6.69˜6.56(m, 3H), 4.87(d, 1H, J=11.2 Hz), 4.53(d, 1H J=11.2 Hz), 4.40(d, 1H, J=7.3 Hz), 4.28(s, 2H), 3.60(d, 1H, J=7.3 Hz), 3.45(s, 3H), 1.41(s, 3H), 1.32(s, 9H), 1.23(s, 3H); MS, m/z: 459.63 
               
               
                 5-227 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.38˜7.26(m, 6H), 7.14˜7.10(m, 2H), 7.00(m, 1H), 6.72˜6.60(m, 3H), 4.91(d, 1H, J=11.9 Hz), 4.71(d, 1H, J=11.7 Hz), 4.42(d, H, J=7.4 Hz), 4.27(s, 2H), 3.55(d, 1H, J=7.45 Hz), 3.44(s, 3H), 1.42(s, 3H), 1.24(s, 3H); MS, m/z: 421.52 
               
               
                 5-228 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.37˜7.18(m, 9H), 6.68˜6.51(m, 3H), 4.92(d, 1H, J=11.8 Hz), 4.69(d, 1H, J=11.8 Hz), 4.41(d, 1H, J=7.2 Hz), 4.27(s, 2H), 3.62(d, 1H, J=7.2 Hz), 3.42(s, 3H), 2.37(s, 3H), 1.39(s, 3H), 1.22(s, 3H); MS, m/z: 417.55 
               
               
                 5-229 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 437.97 
               
               
                 5-230 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.38˜7.23 (m, 9H), 6.98˜6.51(m, 3H), 4.92(d, 1H, J=11.3 Hz), 4.73 (d, 1H, J=11.3 Hz), 4.36(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.58(d, 1H, J=7.3 Hz), 3.42(m, 3H), 1.57˜1.23 (m, 9H); MS, m/z: 437.97 
               
               
                 5-231 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.34˜7.26(7H), 7.16(d, 2H, J=7.8 Hz), 6.94(s, 1H), 6.78(m, 1H), 6.67(d, 1H, J=8.7 Hz), 4.84(d, 1H, J=11.3 Hz), 4.65(d, 1H, J=11.3 Hz), 4.33(d, 1H, J=7.1 Hz), 4.25(s, 2H), 3.56(d, 1H, J=7.1 Hz), 3.47(s, 3H), 2.35(s, 3H), 1.38(s, 3H), 1.22(s, 3H); MS, m/z: 417.55 
               
               
                 5-232 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.38˜7.23(m, 8H), 6.66˜6.57(m, 3H), 4.89(d, 1H, J=11.9 Hz), 4.72(d, 1H, J=11.9 Hz), 4.40(d, 1H, J=7.4 Hz), 4.27(s, 2H), 3.59(d, 1H, J=7.4 Hz), 3.45(s, 3H), 1.39(s, 3H), 1.20(s, 3H); MS, m/z: 500.41 
               
               
                 5-233 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 453.59 
               
               
                 5-234 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-235 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 327.43 
               
               
                 5-236 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.54 
               
               
                 5-237 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 367.49 
               
               
                 5-238 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 353.47 
               
               
                 5-239 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 351.45 
               
               
                 5-240 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 417.55 
               
               
                 5-241 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.54 
               
               
                 5-242 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 
               
               
                 5-243 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-244 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.54 
               
               
                 5-245 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-246 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.00 
               
               
                 5-247 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.00 
               
               
                 5-248 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-249 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 514.44 
               
               
                 5-250 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 467.61 
               
               
                 5-251 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 553.55 
               
               
                 5-252 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 341.45 
               
               
                 5-253 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 397.56 
               
               
                 5-254 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 381.52 
               
               
                 5-255 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 367.49 
               
               
                 5-256 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 365.48 
               
               
                 5-257 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-258 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.57 
               
               
                 5-259 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 487.69 
               
               
                 5-260 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.57 
               
               
                 5-261 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.61 
               
               
                 5-262 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 466.03 
               
               
                 5-263 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 466.03 
               
               
                 5-264 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.61 
               
               
                 5-265 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 528.47 
               
               
                 5-266 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 481.64 
               
               
                 5-267 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 567.59 
               
               
                 5-268 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 355.48 
               
               
                 5-269 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 411.59 
               
               
                 5-270 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 395.55 
               
               
                 5-271 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 381.52 
               
               
                 5-272 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.61 
               
               
                 5-273 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.60 
               
               
                 5-274 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 501.72 
               
               
                 5-275 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.60 
               
               
                 5-276 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.63 
               
               
                 5-277 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 480.05 
               
               
                 5-278 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 480.05 
               
               
                 5-279 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.63 
               
               
                 5-280 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 542.49 
               
               
                 5-281 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 495.67 
               
               
                 5-282 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 581.60 
               
               
                 5-283 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 369.51 
               
               
                 5-284 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 425.62 
               
               
                 5-285 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 409.57 
               
               
                 5-286 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 395.55 
               
               
                 5-287 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 393.53 
               
               
                 5-288 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.34˜7.25 (m, 15H), 6.68˜6.52 (m, 3H), 4.89 (d, 1H, J=11.4 Hz), 4.78˜4.60 (m, 3H), 4.20 (s, 2H), 3.69 (d, 1H, J=7.2 Hz), 1.43 (s, 3H), 1.27 (s, 3H); MS, m/z: 479.62 
               
               
                 5-289 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.35˜7.24 (m, 10H), 7.06˜6.97 (m, 4H), 6.98˜6.57 (m, 3H), 4.85 (d, 1H, J=11.5 Hz), 4.70 (m, 4H), 4.21 (s, 2H), 3.68 (d, 1H, J=7.0 Hz), 1.43 (s, 3H), 1.26 (s, 3H); MS, m/z: 497.62 
               
               
                 5-290 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.42˜7.25 (m, 14H), 6.68˜6.55 (m, 3H), 4.85 (d, 1H, J=11.2 Hz), 4.73˜4.58 (m, 4H), 4.12 (s, 2H), 3.69 (d, 1H, J=7.2 Hz), 1.33 (s, 3H), 1.32 (s, 9H), 1.26 (s, 3H); MS, m/z: 535.73 
               
               
                 5-291 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.35˜7.25 (m, 10H), 7.11˜6.94 (m, 4H), 6.65˜6.52 (m, 3H), 4.87 (d, 1H, J=12.2 Hz), 4.70 (m, 2H), 4.21 (s, 2H), 3.69 (d, 1H, J=7.2 Hz), 1.45 (s, 3H), 1.28 (s, 3H); MS, m/z: 497.62 
               
               
                 5-292 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.40˜7.18 (m, 13H), 6.65˜6.56 (m, 3H), 4.92 (d, 1H, J=11.6 Hz), 4.73˜4.61 (m, 2H), 4.21 (s, 2H), 3.73 (d, 1H, J=7.2 Hz), 2.31 (s, 3H), 1.42 (s, 9H), 1.28 (s, 3H); MS, m/z: 493.65 
               
               
                 5-293 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 393.65 
               
               
                 5-294 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.35˜7.19 (m, 14H), 6.68˜6.55 (m, 3H), 4.80 (d, 1H, J=11.2 Hz), 4.69˜4.61 (m, 3H), 4.20 (s, 2H), 3.67 (d, 1H, J=7.2 Hz), 1.44 (s, 3H), 1.27 (s, 3H); MS, m/z: 514.07 
               
               
                 5-295 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.34˜7.12 (m, 13H), 6.63˜6.58 (m, 3H), 4.90 (d, 1H, J=11.6 Hz), 4.73˜4.61 (m, 2H), 4.19 (s, 2H), 3.67 (d, 1H, J=7.0 Hz), 2.34 (s, 3H), 1.42 (s, 9H), 1.25 (s, 3H); MS, m/z: 493.65 
               
               
                 5-296 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.35˜7.20 (m, 13H), 6.63˜6.56 (m, 3H), 4.78 (d, 1H, J=11.4 Hz), 4.72˜4.69 (m, 3H), 4.59 (d, 1H, J=7.2 Hz), 4.20 (s, 2H), 3.68 (d, 1H, J=7.2 Hz), 1.42 (s, 3H), 1.24 (s, 3H); MS, m/z: 576.51 
               
               
                 5-297 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.84˜7.76 (m, 14H), 7.50˜7.45 (m, 3H), 7.32˜7.25 (m, 10H), 6.70˜6.55 (m, 3H), 5.03 (d, 1H, J=11.6 Hz), 4.86 (d, 1H, J=11.6 Hz), 4.70 (m, 2H), 4.20 (s, 2H), 3.74 (d, 1H, J=7.0 Hz), 1.44 (s, 3H), 1.29 (s, 3H); MS, m/z: 529.69 
               
               
                 5-298 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.79˜7.74 (m, 3H), 7.37˜7.22 (m, 10H), 6.70˜6.55 (m, 3H), 4.96 (d, 1H, J=12.6 Hz), 4.77 (d, 1H, J=12.6 Hz), 4.70 (m, 4H), 4.22 (s, 2H), 3.71 (d, 1H, J=7.6 Hz), 1.46 (s, 3H), 1.28 (s, 3H); MS, m/z: 507.68 
               
               
                 5-299 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.39˜7.26 (m, 10H), 6.67˜6.50 (m, 3H), 4.81 (d, 1H, J=11.4 Hz), 4.72 (d, 1H, J=11.4 Hz), 4.50 (d, 1H, J=7.0 Hz), 4.20 (s, 2H), 3.60 (s, 2H), 3.41 (d, 1H, J=7.0 Hz), 1.44 (s, 3H), 1.23˜(s, 3H); MS, m/z: 403.53 
               
               
                 5-300 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.63 
               
               
                 5-301 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 443.59 
               
               
                 5-302 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 429.56 
               
               
                 5-303 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 427.55 
               
               
                 5-304 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 493.65 
               
               
                 5-305 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.30˜6.91 (m, 14H), 6.57˜6.30 (m, 3H), 4.62 (d, 1H, J=11.2 Hz), 4.48 (d, 1H, J=11.2 Hz), 4.35 (d, 1H, J=8.0 Hz), 4.12 (s, 2H), 3.80˜3.74 (m, 2H), 3.46 (d, (d, 1H, J=8.0 Hz), 2.79 (t, 2H, J=6.2 Hz), 1.28 (s, 3H), 1.12 (s, 3H); MS, m/z: 511.64 
               
               
                 5-306 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.32˜7.27 (m, 14H), 6.57˜6.30 (m, 3H), 4.64 (d, 1H, J=11.2 Hz), 4.50 (d, 1H, J=11.2 Hz), 4.36 (d, 1H, J=8.0 Hz), 4.11 (s, 2H), 3.80˜3.74 (m, 2H), 4.46 (d, 1H, J=8.0 Hz), 2.80 (t, 2H, J=6.2 Hz), 1.34 (s, 3H), 1.25 (s, 3H); MS, m/z: 549.76 
               
               
                 5-307 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300 MHz, CDCl 3 ) δ 7.30˜7.19 (m, 11H), 7.13(m, 1H), 7.04(m, 2H), 6.98(m, 1H), 6.62 (d, 1H, J=5.2 Hz), 6.52 (dd, 1H, J=5.2 Hz, J=1.5 Hz), 6.36 (d, 1H, J=1.5 Hz), 4.72 (d, 1H, J=7.1 Hz), 4.58 (d, 1H, J=7.1 Hz), 4.44 (d, 1H, J=4.6 Hz), 4.19 (s, 2H), 3.55 (m, 2H), 3.85 (d, 1H, J=4.6 Hz), 2.86 (t, 2H, J= 4.0 Hz), 1.38 (s, 3H), 1.21 (s, 3H); MS, m/z: 511.64 
               
               
                 5-308 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.30˜7.04 (m, 14H), 6.55(d, 1H, J=8.6 Hz), 6.45 (dd, 1H, J=8.6 Hz, J=2.4 Hz), 6.29 (d, 1H, J=2.4 Hz), 4.75 (d, H, J=11.8 Hz), 4.56 (d, 1H, J=11.8 Hz), 4.36 (d, 1H, J=7.8 Hz), 4.11 (s, 2H), 3.78 (m, 2H), 3.52 (d, 1H, J=7.8 Hz), 2.79 (t, 2H, J=6.6 Hz), 2.25 (s, 3H), 1.28 (s, 3H), 1.13 (s, 3H); MS, m/z: 507.68 
               
               
                 5-309 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.42˜7.03 (m, 14H), 6.60˜6.29 (m, 3H), 4.85 (d, 1H, J=12.8 Hz), 4.72 (d, 1H, J=12.8 Hz), 4.38 (d, 1H, J=7.6 Hz), 4.12 (s, 2H), 3.82˜3.76 (m, 2H), 3.55 (d, 1H, J=7.6 Hz), 2.79 (t, 2H, J=6.2 Hz), 1.28 (s, 3H), 1.12 (s, 3H); MS, m/z: 528.10 
               
               
                 5-310 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.30˜7.05 (m, 14H), 6.57˜6.28 (m, 3H), 4.63 (d, 1H, J=12.0 Hz), 4.47 (d, 1H, J=12.0 Hz), 4.36 (d, 1H, J=7.8 Hz), 4.12 (s, 2H), 3.80˜3.73 (m, 2H), 3.46 (d, 1H, J=7.8 Hz), 2.78 (t, 2H, J=6.4 Hz), 1.30 (s, 3H), 1.13 (s, 3H); MS, m/z: 528.10 
               
               
                 5-311 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.28˜7.04 (m, 14H), 6.60˜6.27 (m, 3H), 4.63 (d, 1H, J=11.2 Hz), 4.39 (d, 1H, J=11.2 Hz), 4.42 (d, 1H, J=7.6 Hz), 4.12 (s, 2H), 3.80˜3.75 (m, 2H), 3.46 (d, 1H, J=7.6 Hz), 2.78 (t, 2H, J=6.4 Hz), 2.27 (s, 3H), 1.28 (s, 3H), 1.15 (s, 3H); MS, m/z: 507.68 
               
               
                 5-312 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300 MHz, CDCl 3 ) δ 7.38˜7.19 (m, 12H), 6.98˜6.62 (m, 3H), 4.47 (d, 1H, J=5.5 Hz), 4.60 (d, 1H, J=5.5 Hz), 4.40 (d, 1H, J=4.6 Hz), 4.18 (s, 2H), 3.90˜3.84 (m, 2H), 3.54 (d, 1H, J=4.6 Hz), 2.87 (t, 2H, J=4.0 Hz), 1.33 (s, 3H), 1.18 (s, 3H); MS, m/z: 590.54 
               
               
                 5-313 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 543.71 
               
               
                 5-314 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 629.65 
               
               
                 5-315 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300 MHz, CDCl 3 ) δ 7.37˜7.13 (m, 10H), 6.98˜6.62 (m, 3H), 4.31 (d, 1H, J=4.6 Hz), 4.17 (s, 2H), 3.98˜3.88 (m, 2H), 3.51 (s, 3H), 3.27 (d, 1H, J=4.6 Hz), 2.87 (t, 2H, J=4.1 Hz), 1.38 (s, 3H), 1.18 (s, 3H); MS, m/z: 417.55 
               
               
                 5-316 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-317 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 457.62 
               
               
                 5-318 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 443.59 
               
               
                 5-319 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 441.58 
               
               
                 5-320 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 499.70 
               
               
                 5-321 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300 MHz, CDCl 3 ) δ 7.35˜7.23 (m, 9H), 7.07˜6.67 (m, 3H), 4.82 (d, 1H, J=11.4 Hz), 4.64 (d, 1H, J=11.4 Hz), 4.34 (d, 1H, J=7.0 Hz), 3.70˜3.64 (m, 2H), 3.53 (d, 1H, J=7.0 Hz), 1.70˜1.15 (m, 19H); MS, m/z: 517.69 
               
               
                 5-322 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300 MHz, CDCl 3 ) δ 7.40˜7.15 (m, 9H), 6.73˜6.68 (m, 3H), 4.81 (d, 1H, J=11.3 Hz), 4.64 (d, 1H, J=11.3 Hz), 4.30 (d, 1H, J=6.7 Hz), 4.22 (s, 2H), 3.72˜3.68 (m, 2H), 3.52 (d, 1H, J=76.7 Hz), 1.71˜0.92 (m, 33H); MS, m/z: 555.81 
               
               
                 5-323 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300 MHz, CDCl 3 ) δ 7.32˜7.25 (m, 6H), 7.12˜6.67 (m, 6H), 4.87 (d, 1H, J=11.9 Hz), 4.68 (d, 1H, J=11.9 Hz), 4.36 (d, 1H, J=7.1 Hz), 4.23 (s, 2H), 3.68 (t, 2H, J=6.9 Hz), 3.54 (d, 1H, J=7.1 Hz), 1.68˜0.87 (m, 19H); MS, m/z: 517.69 
               
               
                 5-324 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300 MHz, CDCl 3 ) δ 7.35˜7.10 (m, 9H), 6.93˜6.68 (m, 3H), 4.86 (d, H, J=11.7 Hz), 4.67 (d, 1H, J=11.7 Hz), 4.33 (d, 1H, J=6.8 Hz), 4.23 (s, 2H), 3.69˜3.63 (m, 2H), 3.56 (d, 1H, J=6.8 Hz), 1.53˜0.90 (m, 19H): MS, m/z: 513.73 
               
               
                 5-325 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300 MHz, CDCl 3 ) δ 7.39˜7.25 (m, 9H), 6.70˜6.64 (m, 3H), 5.00 (d, 1H, J=12.8 Hz), 4.79 (d, 1H, J=12.8 Hz), 4.35 (d, 1H, J=7.4 Hz), 4.27 (s, 2H), 3.70˜3.64 (m, 2H), 1.66˜0.84 (m, 19H); MS, m/z: 534.14 
               
               
                 5-326 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.36˜7.26 (m, 9H), 6.68˜6.54 (m, 3H), 4.87 (d, 1H, J=12.0 Hz), 4.68 (d, 1H, J=12.0 Hz), 4.40 (d, 1H, J=6.7 Hz), 4.28 (s, 2H), 3.70˜3.56 (m, 3H), 1.65˜1.24 (m, 19H); MS, m/z: 596.59 
               
               
                 5-327 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 513.73 
               
               
                 5-328 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 596.59 
               
               
                 5-329 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 549.76 
               
               
                 5-330 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 635.70 
               
               
                 5-331 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.36˜6.97 (m, 7H), 6.75˜6.67 (m, 1H), 4.25 (d, 1H, J=6.4 Hz), 4.21 (m, 2H), 3.83˜3.62 (m, 4H), 3.32 (d, 1H, J=6.4 Hz), 1.70˜0.95 (m, 28H); MS, m/z: 479.71 
               
               
                 5-332 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 479.71 
               
               
                 5-333 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.67 
               
               
                 5-334 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.64 
               
               
                 5-335 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 447.62 
               
               
                 5-336 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.30(m 4.90(d, 1H, J=11.1Hz), 4.72(d, 1H, J=11.1 Hz), 4.40(d, J=7.3 Hz), 4.20(s, 2H), 3.79(s, 3H) 3.60(d, 1H, J=7.3 Hz), 3.45(s, 3H), 1.40(s, 3H), 1.23(s, 3H); MS, m/z: 433.55 5-337 
               
               
                 5-337 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 6.95˜7.40(m, 8H), 6.75(m, 3H), 4.83(d, 1H, J=11.4 Hz), 4.65(d, 1H, J=11.4 Hz), 4.15(s, 2H), 4.2 3.50(s, 3H), 1.40(s, 3H), 1.23(s, 3H); MS, m/z: 451.54 
               
               
                 5-338 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.10˜7.40(m, 7H), 6.90(d, 1H, J=8.6 Hz), 6.75(m, 3H), 4.83(d, 1H, J=11.3 Hz), 4.65(d, 1H, J=11 3.53(d, 1H, J=6.9 Hz), 3.50(s, 3H), 1.32(m, 15H) MS, m/z: 489.66 
               
               
                 5-339 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.30(m 6.75(m, 3H), 4.90(d, 1H, J=11.3 Hz), 4.70(d, 1H, J=11.3 Hz), 4.40(d, J=6.9 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.61(d, 1H, J=6.9 Hz), 3.45(s, 3H), 1.41(s, 3H), 1.23(s, 3H); MS, m/z: 451.54 
               
               
                 5-340 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.18˜7.42(m, 6H)6.87(d, 2H, J=8.5 Hz), 6.65(m, 2H), 6.56(dd, 1H, J=9.0 Hz, J=2.6 Hz), 4.90(d, 1H, J=11.6 Hz), 4.70(d, 1H, J=11.6 Hz), 4.41 (d, J= 7.5 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.63(d, 1H, J=7.5 Hz), 3.45(s, 3H), 2.38(s, 3H), 1.40(s, 3H), 1.23(s, 3H); MS, m/z: 447.58 
               
               
                 5-341 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.84(m, 2H), 7.26(m, 2H), 6.88(d, 2H, J=8.5 Hz), 6.70˜6.59(m, 3H), 5.06(d, 1H, J=12.5 Hz), 4.84(d, 1H, J=12.5 Hz), 4.50(d, 1H, J=7.7 Hz), 4.22(s, 2H), 3.81(s, 3H), 3.65(d, 1H, J=7.7 Hz), 3.43(s, 3H), 1.46(s, 3H), 1.26(s, 3H); MS, m/z: 468.00 
               
               
                 5-342 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.20˜7.42(m, 6H), 6.87(d, 2H, J=8.5 Hz), 6.65(m, 2H), 6.56(dd, 1H, J=9.1 Hz, J=2.2 Hz), 4.88(d, 1H, J=12.5 Hz), 4.69(d, 1H, J=12.5 Hz), 4.20(s, 2H), 4.40(d, J=7.7 Hz), 3.60(d, 1H, J=7.7 Hz), 3.80(s, 3H), 3.46(s, 3H), 1.30(m, 6H); MS, m/z: 468.00 
               
               
                 5-343 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.10˜7.42(m, 6H)677(d, 2H, J=8.5 Hz), 6.56˜6.70(m, 3H), 4.86(d, 1H, J=11.4 Hz), 4.66(d, 1H, J=11.4 Hz), 4.39(d, J=7.3 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.58(d, 1H, J=7.3 Hz), 3.47(s, 3H), 2.35(s, 3H), 1.30(m, 6H); MS, m/z: 447.58 
               
               
                 5-344 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) d 7.34˜7.22(m, 5H), 6.86(d, 2H), 6.71˜6.60(m, 3H), 4.90(d, 1H, J=11.9 Hz), 4.72(d, 1H, J= 11.9 Hz), 4.39(d, 1H, J=7.2 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.59(d, 1H, J=7.2 Hz), 3.47(s, 3H), 1.40(s, 3H), 1.21 (s, 3H); MS, m/z: 530.44 
               
               
                 5-345 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.57(m, 1H), 7.39˜7.19(m, 8H), 6.86(d, 2H, J=10.2 Hz), 6.73˜6.56(m, 3H), 5.02(d, 1H, J= 12.5 Hz), 4.71(d, 1H, J=12.5 Hz), 4.44(d, 1H, J=7.2 Hz), 3.80(s, 3H), 3.66(d, 1H. J=7.3 Hz0, 3.48(s, 3H), 1.42(s, 3H), 1.26(s, 3H); MS, m/z: 483.61 
               
               
                 5-346 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.82(m, 3H), 7.21(m, 2H), 6.87(d, 2H, J=9.5 Hz), 6.50˜6.70(m, 3H), 5.06(d, 1H,. J=12.4 Hz), 4.84(d, 1H, J=12.4 Hz), 4.49(d, J=7.7 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.64(d, 1H, J=7.7 Hz), 3.42(s, 3H), 1.45(s, 3H), 1.25(s, 3H); MS, m/z: 461.61 
               
               
                 5-347 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.28(m, 2H), 6.87(d, 2H, J=9.0 Hz), 6.65(d, 1H, J=2.5 Hz), 6.62(s, 1H), 6.54(dd, 1H, J=9.0 Hz, J=2.5 Hz), 4.31(d, 1H, J=7.3 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.61(s, 3H), 3.52(s, 3H), 3.34(d, 1H, J=7.3 Hz), 1.41(s, 3H), 1.20(s, 3H); MS, m/z: 357.45 
               
               
                 5-348 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.28(d, 2H, J=8.4 Hz), 6.87(d, 2H, J=8.4 Hz), 6.65(d, 1H, J=2.8 Hz), 6.61(s, 1H), 6.52(dd, 1H, J=8.6 Hz, J=2.8 Hz), 4.30(d, J=7.3 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.50(s, 3H), 3.40(d, 1H, J=7.3 Hz), 1.60(br, 2H), 1.40(s, 3H), 1.21˜1.45(m, 4H), 1.20(s, 3H), 0.91 (br, 3H); MS, m/z: 413.61 
               
               
                 5-349 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.28(d, 2H, J=9.5 Hz), 6.87(d, 2H, J=9.5 Hz), 6.65(m, 2H), 6.52(dd, 1H, J=8.6 Hz, J=2.7 Hz), 5.70(m, 2H), 4.00˜4.40(m, 2H), 4.19(s, 2H), 3.80(s, 3H), 3.50(s, 3H), 1.71 (d, 3H, J=6 Hz), 1.40(s, 3H), 1.21 (s, 3H); MS, m/z: 357.45 
               
               
                 5-350 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.34(d, 1H, J=2.6 Hz), 7.16˜7.16(m, 3H), 6.70(m, 3H), 5.92(m, 1H), 5.34˜5.17(m, 2H), 5.30(dd, 1H, J=17.3 Hz, J=1.6 Hz), 5.19(dd, 1H, J= 10.3 Hz, J=1.6 Hz), 4.20(s, 2H), 3.68(s, 3H), 3.54(s, 3H), 4.43(d, 1H, J=7.1 Hz), 1.40(s, 3H), 1.24(s, 3H); MS, m/z: 383.49 
               
               
                 5-351 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26(d, 2H, J=8.6 Hz), 6.86(d, 2H, J=8.6 Hz), 6.67˜6.55(m, 3H), 4.46˜4.38(m, 3H), 4.19(s, 2H), 3.79(s, 3H), 3.73(d, 1H, J=7.3 Hz), 3.47(s, 3H), 2.54(t, 1H, J=2.4 Hz), 1.43(s, 3H), 1.21 (s, 3H); MS, m/z: 381.48 
               
               
                 5-352 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.25(m, 7H), 6.88(d, 2H, J=8.7 Hz), 6.69˜6.51(m, 3H), 4.91(d, 1H, J=11.4 Hz), 4.71(d, 1H, J=11.4 Hz), 4.45(d, 1H, J=7.5 Hz), 4.21(s, 2H), 3.81(s, 3H), 3.74(m, 2H), 3.61(d, 1H, J=7.5 Hz), 1.41(s, 3H), 1.26(s, 3H), 1.26(t, 3H, J=7.0 Hz); MS, m/z: 447.58 
               
               
                 5-353 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.36˜7.25(m, 4H), 7.06(d, 2H, J=8.6 Hz), 6.87(d, 2H, J=8.6 Hz), 4.86(d, 1H, J=11.5 Hz), 4.67(d, 1H, J=11.5 Hz), 4.43(d, 1H, J=7.6 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.70(q, 2H, J=7.1), 3.58(d, 1H, J=7.6 Hz), 1.39(s, 3H), 1.25(s, 3H), 1.21(m, 3H); MS, m/z: 465.57 
               
               
                 5-354 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.40˜7.28(m, 6H), 6.87(d, 2H, J=8.6 Hz), 6.68˜6.57(m, 3H), 4.86(d, 1H, J=11.2 Hz), 4.68(d, 1H, J=11.2 Hz), 4.429d, 1H, J=7.5 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.71(q, 1H, J=7.1 Hz), 3.59(d, 1H, J=7.5 Hz), 1.41(s, 3H), 1.32(m, 9H), 1.26(s, 3H), 1.27(m, 3H); MS, m/z: 503.69 
               
               
                 5-355 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.37˜7.24(m, 4H), 7.08˜6.91(m, 4H), 6.88(d, 2H, J=8.7 Hz), 6.68˜6.51(m, 3H), 4.92(d, 1H, J=11.7 Hz), 4.71 (d, 1H, J=11.7 Hz), 4.46(d, 1H, J=7.5 Hz), 4.219(s, 2H), 3.81(s, 3H), 3.69(q, 2H, J=7.0 Hz), 3.59(d, 1H, J=7.5 Hz), 1.42(s, 3H), 1.24(s, 3H), 1.23(m, 3H); MS, m/z: 465.57 
               
               
                 5-356 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.14(m, 6H), 6.87(d, 2H, J=8.8 Hz), 6.69˜6.54(m, 3H), 4.93(d, 1H, J=11.7 Hz), 4.70(d, 1H, J=11.7 Hz), 4.459(d, 1H, J=7.7 Hz), 3.80(s, 3H), 3.70(q, 2H, J=7.0 Hz), 3.62(d, 1H, J=7.7 Hz), 1.39(s, 3H), 1.23(s, 3H), 1.23(t, 3H, J=7.7 Hz); MS, m/z: 461.61 
               
               
                 5-357 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.56˜7.52(m, 1H), 7.39˜7.9(m, 5H), 6.87(d, 2H, J=8.7 Hz), 6.70˜6.54(m, 3H), 5.04(d, 1H, J=12.9 Hz), 4.80(d, 1H, J=12.9 Hz), 4.47(d, 1H, J=7.3 Hz), 4.21(s, 2H), 3.80(s, 3H), 3.70(m, 3H), 1.42(s, 3H), 1.26˜1.17(m, 6H); MS, m/z: 482.02 
               
               
                 5-358 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1 1 H NMR(200 MHz, CDCl 3 ) δ 7.38˜7.17(m, 6H), 6.88(d, 2H, J=8.7 Hz), 6.68˜6.51(m, 3H), 4.89(d, 1H, J=11.9 Hz), 4.69(d, 1H, J=11.9 Hz), 4.46(d, H, J=7.6 Hz), 4.21(s, 2H), 3.81(s, 3H), 3.78(m, 2H), 3.59(d, 1H, J=7.6 Hz), 1.42(s, 3H), 1.24(s, 3H), 1.23(m, 3H); MS, m/z: 482.02 
               
               
                 5-359 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.37˜7.08(m, 6H), 6.87(d, 2H, J=8.6 Hz), 6.676.51(m, 3H), 4.86(d, 1H, J=11.2 Hz), 4.65(d, 1H, J=11.2 Hz), 4.42(d, 1H, J=7.5 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.71 (m, 2H), 3.58(d, 1H, J=7.5 Hz), 2.35(s, 3H), 1.40(s, 3H), 1.23(s, 3H), 1.22(m, 3H); MS, m/z: 461.61 
               
               
                 5-360 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.38˜7.22(m, 5H), 6.87(d, 2H, J=8.4 Hz), 6.67˜6.51(m, 3H), 4.90(d, 1H, J=12.1 Hz), 4.71(d, 1H, J=12.1 Hz), 4.43(d, 1H, J=7.5 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.70(m, 2H), 3.59(d, 1H, J=7.5 Hz), 1.40(s, 3H), 1.23(m, 3H), 1.21 (s, 3H); MS, m/z: 544.47 
               
               
                 5-361 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.82(m, 4H), 7.53˜7.46(m, 3H), 7.30(d, 2H, J=8.7Hz), 6.88(d, 2H, J=8.7 Hz), 6.68˜6.52(m,  3H), 5.07(d, 1H, J=11.4 Hz)m, 4.88(d, 1H, J=11.4 Hz), 4.48(d, 1H, J=7.4 Hz), 4.21(s, 2H), 3.80(s, 3H), 3.74(m, 2H), 3.66(d, 1H, J=7.4 Hz), 1.42(s, 3H), 1.26(m, 3H), 1.23(s, 3H); MS, m/z: 497.64 
               
               
                 5-362 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.82(m, 3H), 7.30(d, 2H, J=8.4 Hz), 6.88(d, 2H, J=8.4 Hz), 6.68˜6.52(m, 3H), 5.05(d, 1H, J=12.4 Hz), 4.84(d, 1H, J=12.4 Hz), 4.52(d, 1H, J=7.7 Hz), 4.21(s, 2H), 3.80(s, 3H), 3.74(m, 3H), 1.44(s, 3H), 1.26(m, 3H), 1.20(s, 3H); MS, m/z: 583.58 
               
               
                 5-363 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.29(d, 2H, J=8.4 Hz), 6.87(d, 2H, J=8.4 Hz), 6.66˜6.49(m, 3H), 4.33(d, 1H), 4.20(s, 2H), 3.80(s, 3H), 3.76(m, 2H), 3.60(s, 3H), 3.31(d, 1H, J=7.3 Hz), 1.41(s, 3H), 1.25(t, 3H, J=70 Hz), 1.20(s, 3H); MS, m/z: 371.48 
               
               
                 5-364 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.29(d, 2H, J=8.5 Hz), 6.87(d, 2H, J=8.5 Hz), 6.65˜6.49(m, 3H), 4.33(d, 1H, J=7.8 Hz, 3.80(s, 3H), 3.81(m, 2H), 3.61(m, 2H), 3.38(d, 1H, J=7.8 Hz), 1.61(m, 2H), 1.40(s, 3H), 1.20(s, 3H), 1.50˜1.16(m, 9H), 0.91(m, 3H); MS, m/z: 427.59 
               
               
                 5-365 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.29(d, 2H, J=8.7 Hz), 6.87(d, 2H, J=8.7 Hz), 6.65˜6.49(m ,3H), 5.68(m, 2H), 4.40˜4.10(m, 2H), 4.19(s, 2H), 3.80(s, 3H), 3.76(m, 2H), 3.47(d, 1H, J=7.7 Hz), 1.72(d, 3H, J=5.1 Hz), 1.40(s, 3H), 1.29(m, 3H), 1.20(s, 3H); MS, m/z: 411.55 
               
               
                 5-366 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.29(d, 2H, J=8.7 Hz), 6.87(d, 2H, J=8.7 Hz), 6.60˜6.50(m, 3H), 6.94(m, 2H), 5.29(dd, 1H, J=17.1 Hz, J=1.6 Hz), 5.18(dd, 1H, J=10.3 Hz, J=1.8 Hz), 4.38(m, 2H), 4.19(s, 2H), 4.18(m, 1H), 3.80(s, 3H), 3.76(m, 2H), 3.48(d, 1H, J=7.7 Hz); MS, m/z: 397.52 
               
               
                 5-367 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.28(d, 2H, J=8.7 Hz), 6.86(d, 2H, J=8.7 Hz), 6.67˜6.57(m, 3H), 4.45(d, 2H, J=2.2 Hz), 4.19(s, 2H), 3.80(s, 3H), 3.70(m, 2H), 2.45(t, 1H, J=2.3 Hz), 1.44s, 3H), 1.24(m, 3H), 1.22(s, 3H); MS, m/z: 395.50 
               
               
                 5-368 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 461.61 
               
               
                 5-369 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 479.60 
               
               
                 5-370 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 517.71 
               
               
                 5-371 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z 479.60 
               
               
                 5-372 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 475.63 
               
               
                 5-373 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 496.05 
               
               
                 5-374 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 496.05 
               
               
                 5-375 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 475.63 
               
               
                 5-376 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 558.49 
               
               
                 5-377 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.67 
               
               
                 5-378 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 597.60 
               
               
                 5-379 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 385.51 
               
               
                 5-380 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 441.62 
               
               
                 5-381 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 425.57 
               
               
                 5-382 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 597.60 
               
               
                 5-383 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 409.53 
               
               
                 5-384 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.36˜7.25(m, 7H), 6.86(d, 2H, J=8.5 Hz), 6.69˜6.58(m, 3H), 4.89(d, 1H, J=11.4 Hz), 4.69(d, 1H, J=11.4 Hz), 4.42(d, 1H, J=7.1 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.70(m, 2H), 3.58(d, 1H, J=7.1 Hz), 1.60(m, 2H), 1.50(m, 2H), 1.40(s, 3H), 1.23(s, 3H), 0.91(t, 3H, J=7.3 Hz); MS, m/z: 475.63 
               
               
                 5-385 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.37˜7.23(m, 4H), 7.09˜6.99(m, 2H), 6.86(d, 2H, J=8.6 Hz), 6.70˜6.57(m, 3H), 4.85(d, 1H, J=11.4 Hz), 4.66(d, 1H, J=11.4 Hz), 4.40(d, 1H, J=7.3 Hz), 4.19(s, 2H), 3.79(s, 3H), 3.68˜3.60(m, 2H), 3.57(d, 1H, J= 7.3 Hz), 1.58(m, 2H), 1.38(s, 3H), 1.42˜1.25(m, 2H), 1.22(s, 3H), 0.92(t, 3H, J=7.2 Hz); MS, m/z: 493.62 
               
               
                 5-386 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.32˜7.22(m, 3H), 7.18˜6.99(m, 3H), 6.87(d, 2H, J=8.5 Hz), 6.67˜6.56(m, 3H), 4.90(d, 1H, J=12.0 Hz), 4.69(d, 1H, J=12.0 Hz), 4.43(d, 1H, J=7.3z), 4.20(s, 2H), 3.79(s, 3H), 3.64(m, 2H), 3.58(d, 1H, J=7.3 Hz), 1.57(m, 2H), 1.41(s, 3H), 1.41(m, 2H), 1.24(s, 3H), 0.91(t, 3H, J=7.1 Hz); MS, m/z: 531.74 
               
               
                 5-387 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.32˜7.25(m, 3H), 7.20˜6.99(m, 3H), 6.87(d, 2H, J=8.5 Hz), 6.67˜6.56(m, 3H), 4.90(d, 1H, J=12.0 Hz), 4.69(d, 1H), 4.44(d, 1H, J=7.3 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.61(q, 2H, J=7.5 Hz), 1.58(m, 2H), 1.41(s, 3H), 1.43˜1.24(m, 2H), 1.24(s, 3H), 0.91(t, 3H, J=7.3 Hz): MS, m/z: 493.62 
               
               
                 5-388 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.36˜7.16(m, 6H), 6.86(d, 2H, J=8.7 Hz), 6.67˜6.56(m, 3H), 4.93(d, 1H, J=11.8 Hz), 4.68(d, 1H, J=11.8 Hz), 4.43(d, 1H, J=7.3 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.64˜3.55(m, 3H), 2.35(s, 3H), 1.57(m, 2H), 1.42˜1.30(m, 2H), 1.37(s, 3H), 1.23(s, 3H), 0.90(t, 3H, J=7.2 Hz); MS, m/z: 489.66 
               
               
                 5-389 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.90˜7.73(m, 4H), 7.29(d, 2H, J=8.5 Hz), 6.86(d, 2H, J=8.5 Hz), 5.04(d, 1HJ=12.3 Hz), 4.84(d, 1H, J=12.3 Hz), 4.49(d, 1H, J=7.7 Hz), 4.21(s, 2H), 3.80(s, 3H), 3.70˜3.58(m, 3H), 1.62˜1.20(m, 4H), 1.44(s, 3H), 1.25(s, 3H), 0.89(t, 3H, J=7.1 Hz); MS, m/z: 510.08 
               
               
                 5-390 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.40˜7.25(m, 6H), 7.87(d, 2H, J=6.7 Hz), 6.68˜6.57(m, 3H), 4.87(d, 1H, J=11.8 Hz), 4.68(d, 1H, J=11.8 Hz), 4.43(d, 1H, J=7.4 Hz), 4.20(s, 2fH), 3.79(s, 3H), 3.61 (m, 2H), 4.43(d, 1H, J=7.4H), 1.58(m, 2H), 1.41(3, 3H), 1.41 (m, 2H), 1.24(s, 3H), 0.91(t, 3H, J=7.2 Hz); MS, m/z: 510.08 
               
               
                 5-391 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.32˜7.14(m, 6H), 6.85(d, 2H, J=8.6 Hz), 6.80˜6.60(m, 3H), 4.84(d, 1H, J=11.3 Hz), 4.65(d, 1H, J=11.3 Hz), 4.39(d, 1H, J=7.3 Hz), 4.19(s, 2H), 3.79(s, 3H), 3.76˜3.55(m, 3H), 2.35(s, 3H), 1.59(m, 2H), 1.38(s, 3H), 1.39(m, 2H), 1.22(s, 3H), 0/92(t, 3H, J=7.2 Hz); MS, m/z: 489.66 
               
               
                 5-392 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.38˜7.20(m, 5H), 6.86(d, 2H, J=7.6 Hz), 6.67˜6.55(m, 3H), 4.86(d, 1H, J=11.2 Hz), 4.73(d, 1H, J=11.2 Hz), 4.39(d, 1H, J=7.4 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.64(m, 2H), 3.58(d, 1H, J=7.4H), 1.59(m, 3H), 1.38(s, 3H), 1.39(m, 2H), 1.21(s, 3H), 0.92(t, 3H, J=7.2 Hz); MS, m/z: 572.52 
               
               
                 5-393 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.81(m, 4H), 7.49(m, 3H), 7.2((d, 2H, J=8.7 Hz), 6.87(d, 2H, J=8.7 Hz), 6.68˜6.50(m, 3H), 5.02(d, 1H, J=11.2 Hz), 4.89(d, 1H, J=11.2 Hz), 4.44(d, 1H, J=7.1 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.95(d, 1H, J=7.1 Hz), 3.95(m, 2H), 1.59(m, 2H), 1.41(s, 3H), 1.45(m, 2H), 1.26(s, 3H), 0.89(t, 3H, J=7.2 Hz); MS, m/z: 525.69 
               
               
                 5-394 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.54(m, 1H), 7.41˜7.20(m, 4H), 6.85(d, 2H, J=8.6 Hz), 6.80˜6.60(m, 3H), 5.50(d, 1H, J= 11.4 Hz), 4.81(d, 1H, J=11.4 Hz), 4.20(d, 1H, J=7.3 Hz), 3.78(s, 3H), 3.62(m, 3H), 1.58(m, 2H), 1.41(s, 3H), 1.42(m, 2H), 1.26(s, 3H), 0.89(t, 3H, J=7.2 Hz); MS, m/z: 611.63 
               
               
                 5-395 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.27(d, 2H, J=8.6 Hz), 6.86(d, 2H, J=8.6 Hz), 6.67˜6.57(m, 3H), 4.31(d, 1H, J=7.3 Hz), 419(s, 2H), 3.79(s, 3H), 3.33(m, 3H), 3.60(s, 3H), 6.31(d, 1H, J= 7.3 Hz), 1.60(m, 2H), 1.42(m, 2H), 1.41(s, 3H), 1.20(s, 3H), 0.94(t, 3H, J=7.2 Hz); MS, m/z: 399.53 
               
               
                 5-396 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.27(d, 2H, J=9.0 Hz), 6.86(d, 2H, J=9.0 Hz), 6.78˜6.50(m, 3H), 4.32(d, 1H, J=7.3 Hz), 4.19(s, 2H), 3.79(s, 3H), 3.84˜3.50(m, 4H), 3.38(d, 1H, J=7.3 Hz), 1.60(m, 4H), 1.40(s, 3H), 1.41(m, 6H), 1.20(s, 3H), 0.94(m, 6H); MS, m/z: 455.64 
               
               
                 5-397 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.28(d, 2H, J=8.5 Hz), 6.86(d, 2H, J=8.5 Hz), 5.80˜5.51(m, 2H), 4.35(d, 1H, J=7.3 Hz), 4.19(s, 2H), 4.21(m, 2H), 3.79(s, 3H), 3.75(m, 2H), 3.46(d, 1H, J=7.3H), 1.72(d, 3H, J=5.0 Hz), 1.65(m, 2H), 1.39(s, 3H), 1.40(m, 2H), 1.21(s, 3H), 0.94(t, 3H, J=7.2 Hz); MS, m/z: 439.60 
               
               
                 5-398 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.28(d, 2H, J=8.5 Hz), 6.86(d, 2H, J=8.5 Hz), 6.67˜6.57(m, 3H), 5.97(m, 1H), 5.28(d, 1H, J=18.9 Hz), 5.20(d, 1H, J=10.4˜Hz), 4.35(d, 1H, J=7.2 Hz), 4.19(s, 2H), .20(m, 2H), 3.79(s, 3H), 3.69(m, 2H), 3.48(d, 1H, J=7.2H), 1.60(m, 2H), 1.40(s, 3H), 1.41(m, 2H), 1.22(s, 3H), 0.93(t, 3H, J=7.1 Hz); MS, m/z: 425.57 
               
               
                 5-399 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.28(d, 2H, J=8.7 Hz), 6.86(d, 2H, J=8.7), 6.70˜6.50(m, 3H), 4.43(m, 3H), 4.19(s, 2H), 3.79(s, 3H), 3.67(m, 3H), 2.45(m, 1H), 1.58(m, H), 1.43(s, 3H), 1.44(m, 2H), 1.23(s, 3H), 0.93(t, 3H, J=7.2 Hz); MS, m/z: 423.56 
               
               
                 5-400 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.37˜7.28(m, 12H), 6.86(d, 2H), J=8.5 Hz), 6.69˜6.56(m, 3H), 4.91(d, 1H, J=11.4 Hz), 4.75˜4.61(m, 4H), 4.14(s, 2H), 3.80(s, 3H), 3.71(d, 1H, J= 8.1 Hz), 1.45(s, 3H), 1.28(s, 3H); MS, m/z: 509.65 
               
               
                 5-401 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.36˜7.24(m, 9H), 7.02(m, 2H), 6.84(d, 2H, J=8.8 Hz), 6.70˜6.56(m, 3H), 4.84(d, 1H, J=11.2 Hz), 4.72˜4.59(m, 2H), 4.70(s, 2H), 4.13(s, 2H), 3.77(s, 3H), 3.68(d, 1H, J=7.1 Hz), 1.43(s, 3H), 1.26(s, 3H); MS, m/z: 527.64 
               
               
                 5-402 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.24(m, 11H), 6.86(d, 2H, J=8.7 Hz), 6.69˜6.58(m, 3H), 4.86(d, 1H, J=11.4 Hz), 4.79˜4.58(m, 4H), 4.13(s, 2H), 3.78(s, 3H), 1.44(s, 3H), 1.32(m, 9H), 1.27(s, 3H); MS, m/z: 565.76 
               
               
                 5-403 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.35˜7.25(m, 7H), 7.11˜6.89(m, 4H), 6.86(d, 2H, 8.8 Hz), 6.61˜6.57(m, 3H), 4.88(d, 1H, J=11.4 Hz), 4.71˜4.62(m, 4H), 4.14(s, 2H), 3.79(s, 3H), 3.70(d, 1H, J=7.1 Hz), 1.45(s, 3H), 1.28(s, 3H); MS, m/z: 465.57 
               
               
                 5-404 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.38˜7.17(m, 11H), 6.83(d, 2H, J=8.5 8.5 Hz), 6.70˜6.63(m, 3H), 4.90(d, 1H, J=11.6 Hz), 4.71˜4.59(m, 4H), 4.10(s, 2H), 3.76(s, 3H), 3.71(d, 1H, J= 7.1 Hz), 2.30(s, 3H), 1.41(s, 3H), 1.27(s, 3H); MS, m/z: 523.68 
               
               
                 5-405 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.49˜7.09(m, 11H), 6.94˜6.87(m, 2H), 6.79˜6.69(m, 3H), 4.95(d, 1H, J=12 Hz), 4.91˜4.72(m, 3H), 4.58(d, 1H, J=6.7 Hz), 4.12(s, 2H), 3.67(s, 3H), 3.67(m, 1H), 1.43(s, 3H), 1.31(s, 3H); MS, m/z: 544.10 
               
               
                 5-406 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.35˜7.19(m, 11H), 6.84(d, 2H, J=8.7 Hz), 6.71˜6.63(m, 3H), 4.85(d, 1H, J=12.0 Hz), 4.70(s, 2H), 4.70˜4.60(M, 2H), 4.13(s, 2H), 3.76(s, 3H), 3.67(d, 1H, J=7.3 Hz), 1.44(s, 3H), 1.28(s, 3H); MS, m/z: 544.10 
               
               
                 5-407 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.36˜7.13(m, 11H), 6.84˜6.67(m, 5H), 4.83(d, 1H, J=11.4 Hz), 4.72˜4.56(m, 2H), 4.12(s, 2H), 3.75(s, 3H), 3.66(d, 1H, J=6.9 Hz), 2.35(s, 3H), 1.42(s, 3H), 1.26(s, 3H); MS, m/z: 523.68 
               
               
                 5-408 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.36˜7.21 (m, 10H), 6.85(d, 2H, J=8.7 Hz), 6.69˜6.59(m, 3H), 4.84˜4.58(m, 5H), 4.12(s, 2H), 3.78(s, 3H), 3.69(d, 1H, J=7.1 Hz), 1.42(s, 3H), 1.24(s, 3H); MS, m/z 606.54 
               
               
                 5-409 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.82(m, 4H), 7.47(m, 3H), 7.34˜7.24(m, 7H), 6.85(d, 2H, J=8.5 Hz), 6.72˜6.59(m, 3H), 5.04(d, 1H, J=11.5 Hz), 4.87(d, 1H, J=11.5 Hz), 4.74˜4.64(m, 3H), 4.149s, 2H), 3.78(s, 3H), 3.74(d, 1H, J=7.1 Hz), 1.46(s, 3H), 1.31(s, 3H); MS, m/z: 559.71 
               
               
                 5-410 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 537.71 
               
               
                 5-411 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 433.55 
               
               
                 5-412 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.20(m, 7H), 6.84˜6.65(m, 5H), 4.76(d, 2H, J=4.0 Hz), 4.49(q, 1H, J=17.4 Hz), 4.16(s, 2H), 3.76(m, 1H), 3.75(s, 3H), 3.66(m, 1H), 3.59(d, 1H, J=7.2 Hz), 1.60(br, 2H), 1.43(s, 3H), 1.44˜1.23(m, 4H), 1.24(s, 3H), 0.90(m, 3H); MS, m/z: 489.66 
               
               
                 5-413 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.42˜7.25(m, 7H), 6.86(m, 2H), 6.67˜6.48(m, 3H), 5.68(m, 2H), 4.77(m, 2H), 4.54(d, 1H, J=7.2 Hz), 4.40˜4.15(m, 2H), 4.13(s, 2H), 3.79(s, 3H), 3.58(d, 1H, J=7.2 Hz), 1.73(m, 3H), 1.44(s, 3H), 1.25(s, 3H); MS, m/z: 473.62 
               
               
                 5-414 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.23(m, 7H), 6.85(d, 2H, J=8.7 Hz), 6.68˜6.55(m, 3H), 5.98(m, 1H), 5.30(d, 1H, J=18.9 Hz), 5.19(d, 1H, J=10.4 Hz), 4.75(q, 2H, J=17.4 Hz), 4.55(d, 1H, J=7.2 Hz), 4.42˜4.16(m, 2H), 4.13(s, 2H), 3.79(s, 3H), 3.59(d, 1H, J=7.2 Hz), 1.44(s, 3H), 1.26(s, 3H); MS, m/z: 459.59 
               
               
                 5-415 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 457.57 
               
               
                 5-416 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 523.68 
               
               
                 5-417 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 541.67 
               
               
                 5-418 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 579.79 
               
               
                 5-419 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 541.67 
               
               
                 5-420 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 537.71 
               
               
                 5-421 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 558.12 
               
               
                 5-422 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 558.12 
               
               
                 5-423 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 537.71 
               
               
                 5-424 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 620.56 
               
               
                 5-425 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 573.74 
               
               
                 5-426 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 659.68 
               
               
                 5-527 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 447.58 
               
               
                 5-428 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 503.69 
               
               
                 5-429 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 487.64 
               
               
                 5-430 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.62 
               
               
                 5-431 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 471.60 
               
               
                 5-432 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.88˜7.26(m, 7H), 6.87(d, 2H, J=8.8 Hz), 6.71˜6.589m, 3H), 4.90(d, 1H, J=11.4 Hz), 4.70(d, 1H, J=11.4 Hz), 4.42(d, 1H, J=7.3 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.69(m, 2H), 3.59(d, 1H, J=7.3 Hz), 1.80˜1.19(m, 11H), 1.39(s, 3H), 1.24(s, 3H), 0.91(m, 2H); MS, m/z: 529.73 
               
               
                 5-433 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.40˜7.20(m, 4H), 7.14˜6.96(m, 4H) 6.87(d, 1H, J=8.7 Hz), 6.70˜6.55(m, 3H), 4.85(d, 1H, J=11.5 Hz), 4.67(d, 1H, J=11.5 Hz), 4.41 (d, 1H, J=7.3 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.67(m, 2H), 3.57(d, 1H, J=7.3 Hz0, 1.80˜1.10(m, 11H), 1.39(s, 3H), 1.23(s, 3H), 0.92(m, 2H); MS, m/z: 547.72 
               
               
                 5-434 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.41˜7.26(m, 6H), 6.86(d, 2H, J=8.5 Hz), 6.71˜6.55(m, 3H), 4.85(d, 1H, J=11.2 Hz), 4.68(d, 1H, J=11.2 Hz), 4.40(d, 1H, J=7.5 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.70(m, 2H), 3.58(d, 1H, J=7.5 Hz), 1.80˜1.05(m, 11h)1.41(s, 3H), 1.32(m, 9H), 1.23(s, 3H), 0.91(m, 2H); MS, m/z: 585.83 
               
               
                 5-435 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.33˜7.26(m, 4H), 7.14˜6.98(m, 2H), 6.88(d, 2H, J=8.7 Hz), 6.67˜6.56(m ,3H), 4.90(d, 1H, J=11.9 Hz), 4.70(d, 1H, J=11.9 Hz), 4.44(d, 1H, K=7.5 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.68(t, 2H, J=6.6 Hz), 3.59(d, 1H, J=7.5 Hz), 1.80˜1.05(m, 11H), 1.40(s, 3H), 1.24(s, 3H), 0.91 (2H); MS, m/z: 547.72 
               
               
                 5-436 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 543.75 
               
               
                 5-437 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.82(m, 4H), 7.29(d, 2H, J=8.6 Hz), 6.87(d, 2H, J=8.6 Hz), 5.04(d, 1H, J=12.7 Hz), 4.83(d, 1H, J=12.7 Hz), 4.48(d, 1H, J=7.6 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.64(m, 2H), 3.63(d, 1H, J=7.6 Hz), 1.80˜1.05(m, 11H), 1.43(s, 3H), 1.25(s, 3H), 0.88(m, 2h); MS, m/z: 564.17 
               
               
                 5-438 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.37˜7.20(m, 6H), 6.86(d, 2H, J=8.6 Hz), 6.73˜6.62(m, 3H), 4.87(d, 1H, J=11.8 Hz), 4.68(d, 1H, J=11.8 Hz), 4.41 (d, 1H, J=7.7 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.68(t, 2H, J=6.6 Hz), 3.57(d, 1H, J=7.7 Hz), 1.80˜1.05(m, 11H), 1.41(s, 3H), 1.24(s, 3H), 0.90(m, 2H); MS, m/z: 564.17 
               
               
                 5-439 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.29˜7.14(m, 6H), 6.87˜6.78(m, 3H), 6.65(s, 2H), 4.83(d, 1H, J=11.3 Hz), 4.65(d, 1H, J=11.3 Hz), 4.38(d, 1H, J=7.0 Hz), 4.19(s, 2H), 3.78(s, 3H), 3.66(m, 2H), 3.56(d, 1H, J=7.1 Hz), 1.38(s, 3H), 1.80˜1.04(m, 11H), 1.38(s, 3H), 1.23(s, 3H), 0.94(m, 2H)543.75 
               
               
                 5-440 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.38˜7.22(m, 5H), 6.87(d, 2H, J=8.6 Hz), 6.67˜6.51(m, 3H), 4.87(d, 1H, J=12.0 Hz), 4.71(d, 1H, J=12.0 Hz), 3.80(s, 2H), 2.17(s, 3H), 1.80˜1.05(m, 11H), 1.39(s, 3H), 1.21(s, 3H), 0.93(m, 2H); MS, m/z: 626.61 
               
               
                 5-441 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.86˜7.80(m, 4H), 7.51˜7.46(m, 3H), 7.27˜7.23(d, 2H, J=8.1 Hz), 7.01˜6.65(m, 5H), 5.03(d, 1H, J=11.7 Hz), 4.36(d, 1H, J=11.7 Hz), 4.41(d, 1H, J=7.0 Hz), 4.18(s, 2H), 3.75(s, 3H), 3.68(m, 2H), 3.62(d, 1H, J=7.0 Hz), 1.78˜0.76(m, 13 Hz), 1.39(s, 3H), 1.27(s, 3H); MS, m/z: 579.79 
               
               
                 5-442 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.54(m, 1H), 7.38˜7.23(m, 4H), 6.86(d, 2H, J=8.7 Hz), 6.79˜6.60(m, 3H), 5.01(d, 1H, J=12.8 Hz), 4.80(d, 1H, J=12.8 Hz), 4.4(d, 1H, J=7.3 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.77˜3.63(m, 3H), 1.80˜1.05(m, 11H), 1.41(s, 3H), 1.26(s, 3H), 0.88(m, 2H); MS, m/z: 665.72 
               
               
                 5-443 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.27(d, 2H, J=8.5 Hz), 6.85(d, 2H, J=8.5 Hz), 6.73˜6.59(m, 3H), 4.30(d, 1H, J=7.5 Hz), 4.19(s ,2H), 3.79(s, 3H), 3.77(m, 2H), 3.59(m, 2H), 3.98(d, 1H, J=7.5 Hz), 1.80˜1.05(m, 17H), 0.90(m, 5H); MS, m/z: 509.74 
               
               
                 5-444 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.27(d, 2H, J=8.5 Hz), 6.85(d, 2H, J=8.5 Hz), 6.73˜6.59(m, 3H), 4.30(d, 1H, J=7.5 Hz), 4.19(s ,2H), 3.79(s, 3H), 3.77(m, 2H), 3.59(m, 2H), 3.98(d, 1H, J=7.5 Hz), 1.80˜1.05(m, 17H), 0.90(m, 5H); MS, m/z: 509.74 
               
               
                 5-445 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.25(d, 2H, J=8.7 Hz), 6.93˜6.23(m, 5H), 5.80˜5.50(m, 2H), 4.28(d, 1H, J=6.9 Hz), 4.17(s, 2H), 4.13(m, 2H), 3.75(s, 3H), 3.73(m, 2H), 3.43(d, 1H, J=7.1 Hz), 1.80˜1.05(m, 11H), 1.72(d, 3H, J=5.9 Hz), 1.39(s, 3H), 1.22(s, 3H), 0.94(m, 2H); MS, m/z: 493.69 
               
               
                 5-446 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.25(d, 2H, J=8.5 Hz), 6.88˜6.62(m, 5 Hz), 5.84(m, 1H), 5.29(dd, 1H, J=17.1 Hz, J=1.5 Hz), 5.18(dd, 1H, J=10.2 Hz, J=1.4 Hz), 4.32(d, 1h, J=7.3 Hz), 4.17(s, 2H), 3.76(s, 3H), 3.74(m, 2H), 3.46(d, 1H, J=7.3 Hz), 1.80˜1.05(m, 11H), 1.40(s, 3H), 1.23(s, 3H), 0.90(m, 2H); MS, m/z: 479.67 
               
               
                 5-447 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.25(d, 2H, J=8.5 Hz), 6.85˜6.68(m, 5H), 4.42(d, 2H, J=2.4 Hz), 4.37(d, 1H, J= 7.1 Hz), 4.17(s, 2H), 3.76(s, 3H), 3.75˜3.65(m, 3H), 2.46(t, 1H, J=2.3 Hz), 1.80˜1.05(m, 11H), 1.43(s, 3H), 1.23(s, 3H), 0.95(m, 2H); MS, m/z: 477.65 
               
               
                 5-448 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.03˜7.41(m, 7H), 6.98˜7.06(m, 2H), 6.64(s, 1H), 6.67(d, 1H, J=6.3 Hz), 6.53(dd, 1H, J=2.8 Hz, J=8.7 Hz), 4.92(d, 1H, J=11.4 Hz), 4.72(d, 1H, J=11.5 Hz), 4.41(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.61(d, 1H, J=7.3 Hz), 3.45(s, 3H), 1.41(s, 3H), 1.24(s, 3H); MS, m/z: 421.52 
               
               
                 5-449 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.30˜7.39(m, 4H), 6.97˜7.08(m, 4H), 6.64(s, 1H), 6.50˜6.68(m, 2H), 4.87(d, 1H, J=11.4 Hz), 4.68(d, 1H, J=11.4 Hz), 4.41 (d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.59(d, 1H, J=7.3 Hz), 3.44(s, 3H), 1.40(s, 3H), 1.22(s, 3H); MS, m/z: 439.51 
               
               
                 5-450 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.63 
               
               
                 5-451 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.29˜7.37(m, 3H), 6.97˜7.14(m, 5H), 6.64(s, 1H), 6.51˜6.69(m, 2H), 4.92(d, 1H, J=11.9 Hz), 4.71(d, 1H, J=11.9 Hz), 4.43(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.60(d, 1H, J=7.5 Hz), 3.44(s, 3H), 1.42(s, 3H), 1.24(s, 3H); MS, m/z: 439.51 
               
               
                 5-452 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.30˜7.41(m, 4H), 7.19˜7.24(m, 2H), 6.97˜7.06(m, 2H), 6.69(s, 1H), 6.66(d, 1H, J=7.1 Hz), 6.57(dd, 1H, J=2.6 Hz, J=8.7 Hz), 4.92(d, 1H, J=11.6 Hz), 4.70(d, 1H, J=11.6 Hz), 4.40(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.62(d, 1H, J=7.3 Hz), 3.44(s, 3H), 2.37(s, 3H), 1.39(s, 3H), 1.23(s, 3H); MS, m/z: 435.54 
               
               
                 5-453 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 455.96 
               
               
                 5-454 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.38(m, 6H), 6.95˜7.04(m, 2H), 6.63˜6.74(m, 3H), 4.92(d, 1H, J=11.6 Hz), 4.70(d, 1H, J=11.6 Hz), 4.40(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.58(d, 1H, J=7.3 Hz), 1.41(s, 3H), 1.24(s, 3H); MS, m/z: 455.96 
               
               
                 5-455 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.82˜7.86(m, 2H), 7.31˜7.54(m, 2H), 7.31˜7.26(m, 2H), 6.96˜7.05(m, 2H), 6.92˜6.73(m, 3H), 5.06(d, 1H, J=11.6 Hz), 4.87(d, 1H, J=11.6 Hz), 4.44(d, 1H, J=7.1 Hz), 4.26(s, 2H), 3.66(d, 1H, J=7.1 Hz), 3.46(s, 3H), 1.42(s, 3H), 1.26(s, 3H); MS, m/z: 435.54 
               
               
                 4-456 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.22˜7.38(m, 5H), 6.97˜7.06(m, 2H), 6.66(d, 1H, J=6.7 Hz), 6.63(s, 1H), 6.53(dd, 1H, J=2.8, J=8.5 Hz), 4.89(d, 1H, J=12.0 Hz), 4.72(d, 1H, J=12.0 Hz), 4.39(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.60(d, 1H, J=7.3 Hz), 3.45(s, 3H), 1.39(s, 3H), 1.20(s, 3H); MS, m/z: 518.40 
               
               
                 5-457 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 471.58 
               
               
                 5-458 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.83(s, 3H), 7.29˜7.36(m, 2H), 6.96˜7.05(m, 2H), 6.63˜6.73(m, 3H), 5.05(d, 1H, J=12.6 Hz), 4.83(d, 1H, J=12.6 Hz), 4.46(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.63(d, 1H, J=7.5 Hz), 3.42(s, 3H), 1.45(s, 3H), 1.25(s, 3H); MS, m/z: 557.51 
               
               
                 5-459 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.36(m, 2H), 6.97˜7.05(m, 2H), 6.62˜6.68(m, 2H), 6.53(dd, 1H, J=2.8, J=8.7 Hz), 4.29(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.60(s, 3H), 3.50(s, 3H), 1.41(s, 3H), 1.20(s, 3H); MS, m/z: 345.42 
               
               
                 5-460 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.27˜7.36(m, 2H), 6.96˜7.04(m, 2H), 6.54˜6.69(m, 3H), 4.27(d, 1H, J=7,5 Hz), 4.24(s, 2H), 3.51˜3.88(m, 2H), 3.50(s, 3H), 3.39(d, 1H, J=7.5 Hz), 1.57˜1.61(m, 2H), 1.40(s, 3H), 1.25˜1.36(m, 4H), 1.20(s, 3H), 0.90˜0.94(m, 3H); MS, m/z: 401.53 
               
               
                 5-461 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.30˜7.37(m, 2H), 6.97˜7.05(m, 2H), 6.65(d, 1H, J=4.1 Hz), 6.62(s, 1H), 6.65(dd, 1H, J=2.6 Hz, J=8.7 Hz), 5.58˜5.73(m, 2H), 4.31(d, 1H, J=7.1 Hz), 4.07˜4.26(m, 2H), 4.24(s, 2H), 3.48(d, 1H, J=7.1 Hz), 3.49(s, 3H), 1.72(d, 3H, J=6.1), 1.40(s, 3H), 1.21(s, 3H); MS, m/z: 385.48 
               
               
                 5-462 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMH(200 MHz, CDCl 3 ) δ 7.29˜7.38(m, 2H), 6.96˜7.04(m, 2H), 6.59˜6.71(m, 3H), 5.87˜6.01 (m, 1H), 5.16˜5.34(m, 2H), 4.18˜4.43(m, 2H), 4.24(s, 2H), 3.49(s, 3H), 1.41(s, 3H), 1.22(s, 3H); MS, m/z: 371.46 
               
               
                 5-463 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 369.44 
               
               
                 5-464 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.38(m, 7H), 6.95˜6.04(m, 2H), 6.51˜6.68(m, 3H), 4.90(d, 1H, J=12.0 Hz), 4.71(d, 1H, J=12.0 Hz), 4.43(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.64˜3.23(m, 2H), 3.59(d, 1H, J=7.5 Hz), 1.40(s, 3H), 1.23(s, 3H), 1.18˜1.21(m, 3H); MS, m/z: 435.54 
               
               
                 5-465 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.22˜7.38(m, 4H), 6.96˜7.08(m, 4H), 6.49˜6.69(m, 3H), 4.87(d, 1H, J=11.4 Hz), 4.67(d, 1H, J=11.4 Hz), 4.43(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.64˜3.75(m, 2H), 3.58(d, 1H, J=7.5 Hz), 1.40(s, 3H), 1.22(s, 3H), 1.18˜1.25(m, 3H); MS, m/z: 453.53 
               
               
                 5-466 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.41(m, 6H), 6.95˜7.04(m, 2H), 6.65˜6.75(m, 3H), 4.86(d, 1H, J=11.4 Hz), 4.68(d, 1H, J=11.4 Hz), 4.39(d, 1H, J=7.5 Hz), 4.24(s, 2H), 3.64˜3.74(m, 2H), 3.58(d, 1H, J=7.5 Hz), 1.41(s, 3H), 1.33(s, 9H), 1.31(s, 3H), 1.18˜1.25(m, 3H); MS, m/z: 491.65 
               
               
                 5-467 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.24˜7.38(m, 3H), 6.95˜7.14(m, 5H), 6.50˜6.70(m, 3H), 4.90(d, 1H, J=11.6 Hz), 4.70(d, 1H, J=11.6 Hz), 4.44(d, 1H, J=7.7 Hz), 4.25(s, 2H), 3.63˜3.74(m, 2H), 3.58(d, 1H, J=7.7 Hz), 1.41(s, 3H), 1.23(s, 3H), 1.17˜1.27(m, 3H); MS, m/z: 453.53 
               
               
                 5-468 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.16˜7.40(m, 6H), 6.98˜7.06(m, 2H), 4.50˜6.67(m, 3H), 4.92(d, 1H, J=11.8 Hz), 4.69(d, 1H, J=11.8 Hz), 4.43(d, 1H, J=7.7 Hz), 4.25(s, 2H), 3.63˜3.74(m, 2H), 3.62(d, 1H, J=7.7 Hz), 2.35(s, 3H), 1.38(s, 3H), 1.22(s, 3H), 1.17˜1.20(m, 3H); MS, m/z: 449.57 
               
               
                 5-469 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.18˜7.38(m, 5H), 6.97˜7.06(m, 2H), 6.50˜6.68(m, 3H), 4.02(d, 1H, J=12.4 Hz), 4.79(d, 1H, J=12.4 Hz), 4.46(d, 1H, J=7.5 hz), 4.25(s, 2H), 3.63˜3.75(m, 3H0, 1.41(s, 3H), 1.25(s, 3H), 1.17˜1.24(m, 3H); MS, m/z: 469.99 
               
               
                 5-470 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.14˜7.38(m, 6H), 6.95˜7.06(m, 2H), 6.50˜6.67(m, 3H), 4.88(d, 1H, J=11.8 Hz), 4.64(d, 1H, J=11.8 Hz), 4.43(d, 1H, J=7.9 Hz), 4.25(s, 2H), 3.63˜3.73(m, 2H), 3.58(d, 1H, J=7.9 Hz), 1.41(s, 3H), 1.23(s, 3H), 1.17˜1.21(m, 3H); MS, m/z: 469.99 
               
               
                 5-471 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.14˜7.37(m, 6H), 6.96˜7.05(m, 2H), 6.53˜6.67(m, 3H), 4.85(d, 1H, J=11.2 Hz), 4.65(d, 1H, J=11.2 Hz), 4.40(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.60˜3.75(m, 2H0, 3.57(d, 1H, J=7.5 Hz), 2.35(s, 3H), 1.39(s, 3h), 1.22(s, 3H), 1.18˜1.25(m, 3H); MS, m/z: 449.57 
               
               
                 5-472 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.20˜7.38(m, 5H), 6.95˜7.03(m, 2H), 6.49˜6.68(m, 3H), 4.89(d, 1H, J=11.0 Hz), 4.71(d, 1H, J=11.0 Hz), 4.41(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.65˜3.75(m, 2H), 3.59(d, 1H, J=7.5 Hz), 1.39(s, 3H), 1.20(s, s. 3H), 1.18˜1.21(m, 3H); MS, m/z: 532.43 
               
               
                 5-473 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.76˜7.87(m, 4H), 7.44˜7.53(m, 3H), 7.32˜7.43(m, 2H), 6.96˜7.31(m, 2H), 6.59˜6.69(m, 3H), 5.06(d, 1H, J=11.8 Hz), 4.88(d, 1H, J=11.8 Hz), 4.47(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.69˜3.77(m, 2H), 3.66(d, 1H, J= 7.5 Hz), 1.42(s, 3H), 1.27(s, 3H), 1.19˜1.26(m, 3H); MS, m/z: 485.60 
               
               
                 5-474 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 571.54 
               
               
                 5-475 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 359.44 
               
               
                 5-476 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.37(m, 2H), 6.96˜7.05(m, 2H), 6.50˜6.65(m, 3H), 4.31(d, 1H, J=7.5 Hz), 4.24(s, 2H), 3.57˜3.84(m, 4H), 3.38(d, 1H, J=7.5 Hz), 1.57˜1.63(m, 2H), 1.40(s, 3H), 1.21˜1.37(m, 7H), 1.19(s, 3H), 0.88˜0.94(m, 3H); MS, m/z: 415.55 
               
               
                 5-477 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.37(m, 2H), 6.97˜7.06(m, 2H), 6.47˜6.65(m, 3H), 5.63˜5.71(m, 2H), 4.34(d, 1H, J= 7.9 Hz), 4.24(s, 2H), 4.12˜4.31(m, 2H), 3.70˜3.78(m, 2H), 3.46(d, 1H, J=7.5 hz), 1.72(d, 3H, J=5.3 Hz), 1.40(s, 3H), 1.23˜1.27(m, 3H), 3H), 1.20(s, 3H); MS, m/z: 399.51 
               
               
                 5-478 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.30˜7.37(m, 2H), 6.97˜7.06(m, 2H), 6.01˜6.66(m, 3H), 5.87˜5.98(m, 1H), 5.14˜5.35(m, 2H), 4.36(d, 1H, J=7.5 Hz), 4.24(s, 2H), 4.12˜4.32(m, 2H), 3.66˜3.79(m, 2H), 3.48(d, 1H, J=7.5 Hz), 1.41(s, 3H), 1.23(s, 3H), 1.19˜1.22(m, 3H); MS, m/z: 385.48 
               
               
                 5-479 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.47 
               
               
                 5-480 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 0.76˜0.38(m, 7H), 6.96˜7.07(m, 2H), 6.48˜6.68((m, 3H), 4.88(d, 1H, J=11.4 Hz), 4.69(d, 1H, J=11.4 Hz), 4.37(d, 1H, J=7.1 Hz), 4.25(s, 2H), 3.96˜4.02(m, 1H), 3.52(d, 1H, J=7.1 Hz), 1.38(s, 3H), 1.27(s, 3H), 1.24(d, 3H, J=1.6 Hz), 1.20(d, 3H, J=1.2 Hz); MS, m/z: 449.57 
               
               
                 5-481 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.21˜7.38(m, 4H), 6.94˜7.08(m, 4H), 6.48˜6.69(m, 3H), 4.56˜4.86(m, 2H), 4.36(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.95˜4.01(m, 1H), 3.50(d, 1H, J=7.2 Hz), 1.37(s, 3H), 1.26(2, 3H), 1.21˜1.25(m, 6H); MS, m/z: 467.56 
               
               
                 5-482 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 505.68 
               
               
                 5-483 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.23˜7.38(m, 3H), 6.95˜7.09(m, 5H), 6.48˜6.62(m, 3H), 4.88(d, 1H, J=11.8 Hz), 4.68(d, 1H, J=12.2 Hz), 4.38(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.95˜4.01(m, 1H), 3.51 (d, 1H, J=7.3 Hz), 1.39(s, 3H), 1.28(s, 3H), 1.23(d, 3H, J=2.4 Hz), 1.20(d, 3H, J=2.6 Hz); MS, m/z: 467.56 
               
               
                 5-484 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.16˜7.40(m, 6H), 6.97˜7.06(m, 2H), 6.48˜6.66(m, 3H), 4.87(d, 1H, J=12.0 Hz), 4.70(d, 1H, J=12.0 Hz), 4.36(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.92˜3.99(m, 1H), 3.54(d, 1H, J=7.3 Hz), 2.32(s, 3H), 1.34(s, 3H), 1.28(s, 3H), 1.18˜1.26(m, 6H); MS, m/z: 463.60 
               
               
                 5-485 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.15˜7.48(m, 6H), 6.92˜7.05(m, 2H), 6.54˜6.70(m, 3H), 4.99(d, 1H, J=12.9 Hz), 4.78(d, 1H, J=12.8 Hz), 4.40(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.82˜4.02(m, 1H), 3.58(d, 1H, J=7.3 Hz), 1.39(s, 3H), 1.30(s, 3H), 1.18˜1.26(m, 6H); MS, m/z: 484.02 
               
               
                 5-486 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.16˜7.37(m, 6H), 6.93˜7.03(m, 2H), 6.66˜6.75(m, 3H), 4.85(d, 1H, J=12.0 Hz), 4.67(d, 1H, J=12.0 Hz), 4.36(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.94˜4.03(m, 1H), 3.49(d, 1H, J=7.1 Hz), 1.39(s, 3H), 1.28(s, 3H), 1.19˜1.25(m, 6H); MS, m/z: 484.02 
               
               
                 5-487 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.13˜7.38(m, 6H), 6.79˜7.10(m, 2H), 6.49˜6.65(m, 3H), 4.83(d, 1H, J=11.4 Hz), 4.65(d, 1H, J=11.4 Hz), 4.35(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.96˜4.02(m, 1H), 3.50(d, 1H, J=7.1 Hz), 2.30(s, 3H), 1.37(s, 3H), 1.25(s, 3H), 1.23(d, 3H, J=3.9 Hz), .1.20( o  3H, J=3.9 Hz); MS, m/z: 463.60 
               
               
                 5-488 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.20˜7.37(m, 5H), 6.94˜7.05(m, 2H), 6.53˜6.69(m, 3H), 4.87(d, 1H, J=11.6 Hz), 4.68(d, 1H, J=12.0 Hz), 4.35(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.96˜4.02(m, 1H), 3.51(d, 1H, J=7.1 Hz), 1.37(s, 3H), 1.24(s, 3H), 1.20˜1.22(m, 6H); MS, m/z: 546.46 
               
               
                 5-489 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.75˜7.86(m, 4H), 7.46˜7.51(m, 3H), 7.20˜7.37(m, 2H), 6.96˜7.05(m, 2H), 6.57˜6.69(m, 3H), 5.03(d, 1H, J=11.6 Hz), 4.85(d, 1H, J=11.6 Hz), 4.39(d, 1H, J=7.1 Hz), 4.25(s, 2H), 3.96˜4.03(m, 1H), 3.57(d, 1H, J= 7.1 Hz), 1.39(s, 3H), 1.31 (s, 3H), 1.24(d, 3H, J=3.7 Hz), 1.19(d, 3H, J=3.5 Hz); MS, m/z: 499.63 
               
               
                 5-490 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.80(b, 3H), 7.26˜7.38(m, 2H), 6.97˜6.06(m, 2H), 6.53˜6.68(m, 3H), 5.02(d, 1H, J=12.8 Hz), 4.81(d, 1H, J=12.8 Hz), 4.41(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.92˜3.98(m, 1H), 3.54(d, 1H, J=7.5 Hz), 1.45(s, 3H), 1.30(s, 3H), 1.23(d, 3H, J=6.1 Hz), 1.17(d, 3H, J=6.3 Hz); MS, m/z: 585.57 
               
               
                 5-491 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.38(m, 2H), 6.97˜7.05(m, 2H), 6.48˜6.64(m, 3H), 4.28(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.98˜4.10(m, 1H), 3.58(s, 3H), 3.22(d, 1H, J=7.1 Hz), 1.40(s, 3H), 1.28(s, 3H), 1.26(d, 3H, J=2.2 Hz), 1.23(d, 3H, J=2.2 Hz); MS, m/z: 373.47 
               
               
                 5-492 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.31˜7.38(m, 2H), 6.96˜7.07(m, 2H), 6.49˜6.64(m, 3H), 4.28(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.99˜4.11(m, 1H), 3.78˜3.86(m, 1H), 3.58˜3.76(m, 1H), 3.52˜3.56(m, 1H), 3.31(d, 1H, J=7.1 Hz), 1.44˜1.62(m, 2H), 1.39(s, 3H), 1.30˜1.35(m, 4h), 1.25˜1.26(m, 6H), 1.23(s, 3H); MS, m/z: 429.58 
               
               
                 5-493 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 413.54 
               
               
                 5-494 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.11˜7.36(m, 2H), 6.86˜7.06(m, 2H), 6.72˜6.76(m, 3H), 5.86˜5.99(m, 1H), 5.17˜5.33(m, 2H), 4.23(s, 2H), 4.12˜4.34(m, 3H), 3.98˜4.09(m, 1H), 3.35(d, 1H, J=6.9 Hz), 1.40(s, 3H), 1.23˜1.26(m, 9H); MS, m/z: 399.51 
               
               
                 5-495 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.22˜7.29(m, 2H), 6.89˜6.98(m, 2H), 6.67˜6.88(m, 3H), 4.38˜4.40(m, 2H), 4.34(d, 1H, J= 6.7 Hz), 4.21(s, 2H), 3.99˜4.06(m, 1H), 3.51(d, 1H, J=6.7 Hz), 2.45˜2.47(m, 1H), 1.45(s, 3H), 1.28(b, 6H0, 1.25(s, 3H); MS, m/z: 397.49 
               
               
                 5-496 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.27˜7.38(m, 7H), 6.97˜7.06(m, 2H), 6.54˜6.68(m, 3H), 4.71(d, 1h, J=11.5 Hz), 4.40(d, 1H, J=11.5 Hz), 4.40(d, 1H, J=11.1), 3.57˜4.25(m, 3H), 1.54˜2.17(m, 2H), 1.24˜1.43(m, 2H), 1.40(s, 3H), 1.24(s, 3H), 0.91(t, 3H, J=7.2 Hz); MS, m/z: 463.60 
               
               
                 5-497 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.23˜7.37(m, 4H), 6.92˜7.09(m, 4H), 6.59˜6.73(m, 3h), 4.84(d, 1H, J=11.4 Hz), 4.65(d, 1H, J=11.4 Hz), 4.38(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.58˜3.69(m, 2H), 3.56(d, 1H, J=7.3 Hz), 1.46˜1.61(m, 2H), 1.25˜1.42(m, 2H), 1.38(s, 3H), 1.25(s, 3H), 0.92(t, 3H, J=7.1 Hz); MS, m/z: 481.59 
               
               
                 5-498 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.27˜7.40(m, 6H), 6.93˜7.26(m, 2H), 6.66˜6.82(m, 3H), 4.83(d, 1H, J=11.2 Hz), 4.65(d, 1H, J=11.2 Hz), 4.36(d, 1H, J=6.0 Hz), 4.24(s, 2H0, 3.59˜1.61(m, 2H), 1.24˜1.39(m, 2H), 1.39(s, 3H), 1.32(s, 9H), 1.24(s, 3H), 0.92(t, 3H, J=7.2 Hz); MS, m/z: 519.71 
               
               
                 5-499 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.36(m, 3H), 6.94˜7.13(m, 5H), 6.34˜6.73(m, 3H), 4.89(d, 1H, J=12.0 Hz), 4.69(d, 1H, J=12.0 Hz), 4.40(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.63˜4.19(m, 2H), 3.57(d, 1H, J=7.3 Hz), 1.50˜1.60(m, 2H), 1.27˜1.45(m, 2H), 1.40(s, 3H), 1.24(s, 3H), 0.91(t, 3H, J=7.1 Hz); MS, m/z: 481.59 
               
               
                 5-500 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.16˜7.39(m, 6H), 6.92˜7.05(m, 2H), 6.61˜6.73(m, 3H), 4.91 (d, 1H, J=11.4 Hz), 4.69(d, 1H, J=11.4), 4.40(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.56˜3.73(m, 3H), 2.35(s, 3H), 1.49˜1.60(m, 2H), 1.26˜1.45(m, 2H), 1.40(s, 3H), 1.24(s, 3H), 0.90(t, 3H, J=7.2); MS, m/z: 477.62 
               
               
                 5-501 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 498.04 
               
               
                 5-502 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.16˜7.36(m, 6H), 6.92˜7.04(m, 2H), 6.78(s, 1H), 6.67(d, 2H, J=1.4 Hz), 4.86(d, 1H, J= 11.8 Hz), 4.67(d, 1H, J=11.0 Hz), 4.39(d, 1H, J=7.3 Hz), 3.60˜4.18(m, 2H), 3.56(d, 1H, J=7.3 Hz), 1.50˜1.61(m, 2H), 1.24˜1.44(m, 2H), 1.40(s, 3H), 1.24(s, 3H), 0.91(t, 3H, J= 7.1 Hz); MS, m/z 498.04 
               
               
                 5-503 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.14˜7.35(m, 6H), 6.94˜6.99(m, 2H), 6.78(s, 1H), 6.66(d, 2H, J=1.4 Hz), 4.83(d, 1H, J= 11.2 Hz), 4.64(d, 1H, J=11.2), 4.37(d, 1H, J=7.7), 4.24(s, 2H), 3.57˜3.70(m, 2H), 3.55(d, 1H, J=7.7), 3.54˜3.70(m, 2H), 2.35(s, 3H), 1.54˜1.61(m, 2H), 1.25˜1.51(m, 2H), 1.38(s, 3H), 1.22(s, 3H), 0.92(t, 3H, J=7.1 Hz); MS, m/z: 477.62 
               
               
                 5-504 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 560.48 
               
               
                 5-505 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.80˜7.86(m, 4H), 7.45˜7.50(m, 3H), 7.25˜7.34(m, 2H), 6.93˜6.80(m, 2H), 6.80(s, 1H), 6.67(d, 2H, J=2.0 Hz), 5.03(d, 1H, J=11.6), 4.86(d, 1H, J= 11.6 Hz), 4.42(d, 1H, J=7.1 Hz), 4.23(s, 2H), 3.63˜3.76(m, 2H), 3.28(d, 1H, J=7.1 Hz), 1.50˜1.64(m, 2H), 1.27˜1.46(m, 2H), 1.40(s, 3H), 1.21(s, 3H), 0.85˜0.98(m 3H); MS, m/z: 513.66 
               
               
                 5-506 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 599.59 
               
               
                 5-507 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.14˜7.30(m, 4H), 6.87˜7.01(m, 3H), 4.24(d, 1H, J=6.9 Hz), 4.22(s, 2H), 3.68˜3.78(m, 2H), 3.58(s, 3H), 3.25(d, 1H, J=6.9 Hz), 1.47˜1.66(m, 2H), 1.40˜1.43(m, 2H0, 1.40(s, 3H), 1.23(s, 3H), 0.90˜0.98(m, 3H); MS, m/z: 387.50 
               
               
                 5-508 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.28˜7.36(m, 2H), 6.89˜7.03(m, 2H), 6.62˜6.81(m, 3H), 4.32(d, 1H, J=7.3 Hz), 4,24(s, 2H), 3.55˜3.82(m, 4H), 3.36(d, 1H, J=7.3 Hz), 1.52˜1.75(m, 4H), 1.39(s, 3H), 1.26˜1.49(m, 6h), 1.21(s, 3H), 0.90˜0.98(m, 6H); MS, m/z: 443.61 
               
               
                 5-509 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.37(m, 2H), 6.96˜7.04(m, 2H), 6.56˜6.70(m, 2H), 5.62˜5.71(m, 2H), 4.31(d, 1H, J= 7.1 Hz), 4.24(s, 2H), 4.05˜4.28(m, 2H), 3.48˜3.75(m, 2H), 3.45(d, 1H, J=7.1 Hz), 1.69˜1.73(m, 3H), 1.53˜1.66(m, 2H), 1.39(s, 3H), 1.21(s, 3H), 1.26˜1.45(m, 2H), 0.94(t, 3H, J= 7.1 Hz); MS, m/z: 427.56 
               
               
                 5-510 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.27˜7.37(m, 2H), 6.95˜7.06(m, 2H), 6.52˜6.66(m, 3H), 5.86˜6.05(m, 1H), 5.14˜5.35(m, 2H), 4.34(d, 1H, J=7.3 Hz), 4.11˜4.40(m, 2H), 4.24(s, 2H), 3.58˜3.77(m, 2h), 3.47(d, 1H, J=7.3 Hz), 1.52˜1.66(m, 2H), 1.34˜1.48(m, 2H), 1.40(s, 3H), 1.22(s, 3H), 0.93(t, 3H, J= 7.1 Hz); MS, m/z: 413.54 
               
               
                 5-511 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.37(m, 2H), 6.97˜7.06(m, 2H), 6.50˜6.67(m, 3H), 4.43(dd, 2H, J=0.81, J=2.7), 4.39(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.59˜3.69(m, 3H), 2.44˜2.46(m, 1H), 1.51˜1.61(m, 2H), 1.43(s, 3H), 1.29˜1.40(m, 2H), 1.22(s, 3H), 0.93(t, 3H, J=7.1 Hz); MS, m/z: 411.52 
               
               
                 5-512 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.37(m, 12H), 6.95˜7.04(m, 2H), 6.52˜6.68(m, 3H), 4.89(d, 1H, J=11.4 Hz), 4.67(d, 1H, J=11.6 Hz), 4.73(d, 2H, J=2.8 Hz), 4.60(d, 1H, J=7.3 Hz), 4.17(s, 2H), 3.69(d, 1H, J=7.1 Hz), 1.43(s, 3H), 1.27(s, 3H); MS, m/z: 497.61 
               
               
                 5-513 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.33˜7.56(m, 9H), 6.96˜7.06(m, 4H), 6.49˜6.68(m, 3H), 4.85(d, 1H, J=11.6 Hz), 4.70(d, 2H, J=4.3 Hz), 7.17(s, 2H), 4.17˜4.54(m, 2H), 3.69(d, 1H, J= 7.1 Hz), 1.43(s, 3H), 1.26(s, 3H); MS, m/z: 515.61 
               
               
                 5-514 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.27˜7.40(m, 10H), 6.68˜7.04(m, 2H), 6.50˜6.63(m, 3h0, 4.86(d, 1H, J=11.0 Hz), 4.63˜4.79(m, 3H), 4.59(d, 1H, J=7.5 Hz), 4.17(s, 2H), 3.69(d, 1H, J=7.1 Hz), 1.44(s, 3H), 1.32(s, 9H), 1.26(s, 3H); MS, m/z: 553.72 
               
               
                 5-515 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.34˜7.56(m, 8H), 6.95˜7.11(m, 5H), 6.49˜6.69(m, 3H), 4.89(d, 1H, J=11.8 Hz), 4.67˜4.83(m, 3H), 4.63(d, 1H, J=7.5 Hz), 4.18(s, 2H), 3.69(d, 1H, J=7.5 Hz), 1.45(s, 3H), 1.28(s, 3H); MS, m/z: 535.68 
               
               
                 5-516 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.19˜7.39(m, 11H), 6.96˜7.17(m, 2H), 6.51˜6.69(m, 3H), 4.91 (d, 1H, J=11.6 Hz), 4.67˜4.73(m, 3H), 4.62(d, 1H, J=7.1 Hz), 4.18(s, 2H), 3.73(d, 1H, J=7.1 Hz), 2.30(s, 3H), 1.42(s, 3H), 1.27(s, 3H): MS, m/z: 531.72 
               
               
                 5-517 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 532.06 
               
               
                 5-518 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.17˜7.34(m, 11H), 6.96˜7.04(m, 2H), 6.51˜6.69(m, 3H), 4.86(d, 1H, J=12.0 Hz), 4.61˜4.71(m, 4H), 4.18(s, 2H), 3.68(d, 1H, J=7.3 Hz), 1.45(s, 3H), 1.28(s, 3H); MS, m/z: 532.06 
               
               
                 5-519 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.64 
               
               
                 5-520 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.21˜7.33(m, 10H), 6.95˜7.04(m, 2H), 6.50˜6.68(m, 3H), 4.87(d, 1H, J=12.2), 4.68˜4.74(m, 3H), 4.60(d, 1H, J=7.3 Hz), 4.17(s, 2H), 3.69(d, 1H, J=7.3 Hz), 1.42(s, 3H), 1.24(s, 3H); MS, m/z: 594.50 
               
               
                 5-521 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.76˜7.86(m, 4H), 7.45˜7.50(m, 3H), 7.15˜7.34(m, 7H), 6.95˜7.04(m, 2h), 6.50˜6.69(m, 3H), 5.05(d, 1H, J=11.6 Hz), 4.87(d, 1H, J=11.6 Hz), 4.71(d, 2H, J=7.7 Hz), 4.64(d, 1H, J=6.9 Hz), 4.18(s, 2H), 3.76(d, 1H, J=6.9 Hz), 1.45(s, 3H), 1.30(s, 3H); MS, m/z: 547.68 
               
               
                 5-522 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.79(s, 2H), 7.74(s, 1H), 7.27˜7.34(m, 7H), 6.95˜7.04(m, 2H), 6.51˜6.70(m, 3H), 4.97(d, 1H, J=12.4 Hz), 4.78(d, 1H, J=12.4 Hz), 4.69(d, 1H, J=7.5 Hz), 4.68(s, 2H), 4.19(s, 2H), 3.72(d, 1H, J=7.5 Hz), 1.46(s, 3H), 1.28(s, 3H); MS, m/z: 633.61 
               
               
                 5-523 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.27˜7.39(m, 7H), 6.94˜7.26(m, 2H), 6.57˜6.68(m, 3H), 4.82(d, 1H, J=12.0 Hz), 4.72(d, 1H, J=12.0 Hz), 4.49(d, 1H, J=7.1 Hz), 4.17(s, 2H), 3.60(s, 3H), 3.41(d, 1H, J=7.1 Hz), 1.44(s, 3H), 1.24(s, 3H); MS, m/z: 421.52 
               
               
                 5-524 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.23˜7.38(m, 7H), 6.90˜6.98(m, 2H), 6.66˜6.77(m, 3h), 4.71(d, 1H, J=12.0 Hz), 4.67(d, 1H, J=12.0 Hz), 4.47(d, 1H, J=7.3 Hz), 4.16(s, 2H), 3.52˜3.83(m, 2H), 3.47(d, 1H, J=7.1 Hz), 1.43˜1.60(b, 2H), 1.42(s, 3H), 1.24(s, 3H), 1.30˜1.42(m, 4H), 0.89˜0.93(m, 3H), MS, m/z: 477.62 
               
               
                 5-525 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.38(m, 7H), 6.95˜7.06(m, 2H), 6.48˜6.65(m, 3H), 5.62˜5.70(m, 2H), 4.82(d, 1H, J= 11.6 Hz), 4.71(d, 1H, J=11.6 Hz), 4.52(d, 1H, J=7.1 Hz), 4.08˜4.31(m, 2H), 4.16(s, 2H), 3.57(d, 1H, J=7.1 Hz), 1.63˜1.74(m, 3H), 1.43(s, 3H), 1.24(s, 3H); MS, m/z: 461.58 
               
               
                 5-526 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.14˜7.41(m, 7H), 6.84˜7.06(m, 2H), 6.49˜6.69(m, 3H), 5.87˜6.06(m, 1H), 5.15˜5.34(m, 2H), 4.80(d, 1H, J=11.4 Hz), 4.70(d, 1H, J=11.4 Hz), 4.54(d, 1H, J=7.3 Hz), 4.20˜4.45(m, 2H), 4.17(s, 2H), 3.59(d, 1H, J= 7.3 Hz), 1.44(2, 3H), 1.25(s, 3H); MS, m/z: 447.55 
               
               
                 5-527 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.29˜7.38(m, 7H), 6.94˜7.03(m, 2H), 6.59˜6.69(m, 3H), 4.73(b, 2H), 4.42(d, 2H, J=2.4 Hz), 4.17(s, 2H), 3.80(d, 1H, J=6.5 Hz), 2.46(t, 1H, J=2.3 Hz); MS, m/z: 445.54 
               
               
                 5-528 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.64 
               
               
                 5-529 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.22˜7.37(m, 12 H), 6.90˜7.11(m, 2H), 6.59˜6.84(m, 3H), 4.68(d, 1H, J=11.0 Hz), 4.54(d, 1H, J=11.2 Hz), 4.39(d, 1H, J=7.5 Hz), 4.17(s, 2H), 3.87(t, 2H, J=6.9 Hz), 3.51 (d, 1H, J=7.5 Hz), 2.89(t, 2H, J=6.7 Hz), 1.34(s, 3H), 1.19(s, 3H); MS, m/z: 529.63 
               
               
                 5-530 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.20˜7.35(m, 9H), 6.94˜7.06(m, 4H), 6.43˜6.60(m, 3H), 4.69(d, 1H, J=11.6 Hz), 4.55(d, 1H, J=11.6 Hz), 4.41(d, 1H, J=7.5 Hz), 4.15(s, 2H), 3.82˜3.92(m, 2H), 3.53(d, 1H, J=7.5 Hz), 2.88(t, 2H, J=6.5 Hz), 1.36(s, 3H), 1.19(s, 3H); MS, m/z: 567.75 
               
               
                 5-531 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.64˜7.84(m, 3H), 7.15˜7.39(m, 7H), 6.94˜7.02(m, 2H), 6.69˜6.79(m, 3H), 4.88(d, 1H, J= 11.6 Hz), 4.62(d, 1H, J=11.6 Hz), 4.52(d, 1H, J=9.6 Hz), 4.46(d, 1H, J=7.5 Hz), 4.21(s, 2H), 3.81˜3.92(m, 2H), 3.52(d, 1H, J= 7.9 Hz), 2.87(t, 2H, J=6.9 Hz), 1.38(s, 3H), 1.21(s, 3H); MS, m/z: 529.63 
               
               
                 5-532 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.11˜7.36(m, 11H), 7.01˜7.06(m, 2H), 6.40˜6.97(m, 3H), 4.81(d, 1H, J=11.8 Hz), 4.63(d, 1H, J=11.8 Hz), 4.41(d, 1H, d˜7.5 Hz), 4.15(s, 2H), 3.80˜3.96(m, 2H), 3.59(d, 1H, J=7.5 Hz), 2.87(t, 2H, J=6.7 Hz), 2.32(s, 3H), 1.34(s, 3H), 1.21(s, 3H); MS, m/z: 525.67 
               
               
                 5-533 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.10˜7.37(m, 11H), 6.96˜7.04(m, 2H), 6.52˜6.67(m, 3H), 4.67(d, 1H, J=11.8 Hz), 4.55(d, 1H, J=11.8 Hz), 4.41(d, 1H, J=7.7 Hz), 4.17(s, 2H), 3.83˜3.90(m, 2H), 3.52(d, 1H, J=7.7 Hz), 2.88(t, 2H, J=6.3 Hz), 1.37(s, 3H), 1.21(s, 3H); MS, m/z: 546.09 
               
               
                 5-534 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.15˜7.35(m, 11H), 6.93˜7.10(m, 2H), 6.50˜6.67(m, 3H), 4.67(d, 1H, J=12.2 Hz), 4.54(d, 1H, J=12.0 Hz), 4.42( o  1H, J=7.5 Hz), 4.16(s, 2H), 3.87(t, 2H, J=6.3 Hz), 3.52(d, 1H, J=7.5 Hz), 2.87(t, 2H, J=6.5 Hz), 1.37(s, 3H), 1.21(s, 3H); MS, m/z: 546.09 
               
               
                 5-535 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 525.67 
               
               
                 5-536 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.46˜7.51(m, 1H), 7.13˜7.39(m, 9H), 6.94˜7.06(m, 2H), 6.38˜6.76(m, 3H), 4.92(d, 1H, J= 12.6 Hz), 4.74(d, 1H, J=12.6 Hz), 4.45(d, 1H, J=7.7 Hz), 4.15(s, 2H), 3.87˜3.91(m, 2H), 3.62(d, 1H, J=7.7 Hz), 2.88(t, 2H, J=6.7 Hz), 1.38(s, 3H), 1.23(s, 3H); MS, m/z: 608.53 
               
               
                 5-537 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.73˜7.86(m, 4H), 7.34˜7.50(m, 3H), 7.09˜7.32(m, 7H), 6.95˜7.04(m, 2H), 6.53˜6.63(m, 3H), 4.89(d, 1H, J=11.6 Hz), 4.76(d, 1H, J=11.6 Hz), 4.44(d, 1H, J=7.5 Hz), 4.16(s, 2H), 3.83˜3.94(m, 2H), 3.60(d, 1H, J= 7.5 Hz), 2.87(t, 2H, J=6.5 Hz), 1.37(s, 3H), 1.24(s, 3H); MS, m/z: 531.70 
               
               
                 5-538 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.66˜7.79(m, 3H), 7.11˜7.37(m, 7H), 6.97˜7.06(m, 2H), 6.47˜6.68(m, 3H), 4.66(d, 1H, J= 12.8 Hz), 4.54(d, 1H, J=12.8 Hz), 4.49(d, 1H, J=8.1 Hz), 4.19(s, 2H), 3.78˜3.88(m, 2H), 3.56(d, 1H, J=8.1 Hz), 2.84(t, 2H, J=6.5 Hz), 1.39(s, 3H), 1.21 (s, 3H); MS, m/z: 647.64 
               
               
                 5-539 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.54 
               
               
                 5-540 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 491.65 
               
               
                 5-541 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.11˜7.35(m, 7H), 6.97˜7.06(m, 2H), 6.30˜6.62(m 3H) 6.51˜5.72(m, 2H) 4.13(s, 2H), 3.86˜4.13(m, 5H), 3.44(d, 1H, J=7.5 Hz), 2.91(t, 2H, J= 6.7 Hz), 1.64˜1.73(m, 3H), 1.37(s, 3H), 1.18(s, 3H); MS, m/z: 475.60 
               
               
                 5-542 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.22˜7.37(m, 7H), 6.97˜7.06(m, 2H), 6.34˜6.66(m, 3H), 5.84˜5.98(m, 1H), 5.14˜5.34(m, 2H), 4.14(s, 2H), 3.85˜4.44(m, 5H), 3.44( o  1H, J=7.7 Hz), 2.91(t, 2H, J=6.7 Hz), 1.38(s, 3H), 1.19(s, 3H); MS, m/z: 461.58 
               
               
                 5-543 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.22˜7.35(m, 7H), 6.98˜7.06(m, 2H), 6.30˜6.64(m, 3H), 4.40(d, 1H, J=7.5 Hz), 4.31(d, 2H,J=2.2 Hz), 4.14(s, 2H), 3.84˜3.93(m, 2H), 3.64(d, 1H, J= 7.5 Hz), 2.90(t, 2H, J=6.7 Hz), 2.44(t, 1H, J=2.2 Hz), 1.40(s, 3H), 1.18(s, 3H); MS, m/z: 459.57 
               
               
                 5-544 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.38(m. 7H), 6.94˜7.03(m, 2H), 6.66˜6.78(m, 2H), 4.88(d, 1H, J=11.4 Hz), 4.69(d, 1H, J=11.6 Hz), 4.38(d, 1H, J=7.1 Hz), 1.39(s, 3H), 1.18(s, 3H), 1.14˜1.70(m, 11H), 0.86˜0.92(m, 2H); MS, m/z: 517.69 
               
               
                 5-545 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.28˜7.37(m, 4h), 6.95˜7.08(m, 4H), 6.64˜6.74(m, 3H0, 4.84(d, 1H, J=11.4 Hz), 4.66(d, 1H, J=11.2 Hz), 4.38(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.63˜3.70(m, 2H), 3.56(d, 1H, J=7.1 Hz), 1.38(s, 3H0, 1.23(s, 3H), 1.15˜1.69(m, 11H), 0.80˜0.92(m, 2H); MS, m/z: 535.68 
               
               
                 5-546 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 573.80 
               
               
                 5-547 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.38(m, 3H), 6.98˜7.13(m, 5H), 6.49˜6.67(m, 3H), 4.89(d, 1H, J=12.0 Hz), 4.70(d, 1H, J=12.0 Hz), 4.42(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.62˜3.89(m, 2H0, 3.58(d, 1H, J=7.5 Hz), 1.14˜1.68(m, 11H), 0.85˜0.90(m, 2H); MS, m/z: 535.68 
               
               
                 5-548 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.22˜7.39(m, 6H), 6.94˜7.02(m, 2H0, 6.66˜6.79(m, 3h), 4.90(d, 1H, J=12.0 Hz), 4.69(d, 1H, J=12.0 Hz), 4.39(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.63˜4.19(m, 2H), 3.60(d, 1H, J=7.1 Hz), 2.34(s, 3H), 1.36(s, 3H), 1.24(s, 3H), 1.14˜1.69(m, 11H), 0.85˜0.91(m, 2H); MS, m/z: 531.71 
               
               
                 5-549 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 552.14 
               
               
                 5-550 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.37(m, 6H), 6.96˜7.05(m, 2H), 6.64˜6.72(m, 3H), 4.87(d, 1H, J=12.2 Hz), 4.48(d, 1H, J=12.2 Hz), 4.41(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.63˜3.70(m, 2H), 3.57(d, 1H, J=7.3 Hz), 1.41(s, 3H), 1.25(s, 3H), 1.14˜1.50(m, 11H), 0.86˜0.92(m, 2H); MS, m/z: 552.14 
               
               
                 5-551 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 531.71 
               
               
                 5-552 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.37(m, 5H), 6.98˜7.08(m, 2H), 6.49˜6.66(m, 3H), 4.88(d, 1H, J=12.0 Hz), 4.71(d, 1H, J=12.0 Hz), 4.40(d, 1H, J=7.5 Hz), 4.24(s, 2H), 3.62˜3.68(m, 2H), 3.59(d, 1H, J=7.5 Hz), 1.39(s, 3H), 1.21(s, 3H), 1.14˜1.65(m, 11H), 0.85˜0.96(m, 2H); MS, m/z: 614.58 
               
               
                 5-553 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 567.75 
               
               
                 5-554 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.81(b, 3H). 7.28˜7.38(m, 2H), 6.98˜7.25(m, 2H), 6.50˜6.68(m, 3H), 5.03(d. 1H, J=12.6 Hz), 4.83(d, 1H, J=12.4 Hz), 4.48(d, 1H, J=7.9 Hz), 3.59˜3.67(m, 3H), 1.43(s, 3H), 1.25(s, 3H), 1.11˜1.65(m, 11H), 0.82˜0.88(m, 2H); MS, m/z: 653.69 
               
               
                 5-555 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.35(m, 2H), 6.94˜7.02(m, 2H), 6.65˜6.77(m, 3H), 4.28(d, 1H, J=6.7 Hz), 4.23(s, 2H), 6.64˜6.78(m, 2H), 3.59(s, 3H), 3.29(d, 1H, J=6.7 Hz), 1.40(s, 3H), 1.21(s, 3H), 1.21˜1.75(m, 1H), 0.89˜0.95(m, 2H); MS, m/z 441.59 
               
               
                 5-556 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 497.70 
               
               
                 5-557 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.33(m, 2H), 6.85˜7.01(m, 2H), 6.63˜6.70(m, 3H), 5.61˜5.72(m, 2H). 4.29(d, 1H, J= 6.9 Hz), 4.22(s, 2H), 4.11˜4.22(m, 2H), 3.72˜3.76(m, 2H), 3.44(d, 1H, J=7.1 Hz), 1.39(s, 3H), 1.23(s, 3H), 1.43˜1.74(m, 11H), 0.86˜0.92(m, 2H); MS, m/z: 481.66 
               
               
                 5-558 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.30˜7.37(m, 2H), 6.96˜7.05(m, 2H), 6.57˜6.66(m, 3H), 6.16˜5.34(m, 1H), 5.82˜6.02(m, 1H), 4.34(d, 1H, J=7.1 Hz), 4.24(s, 2H), 4.18˜4.36(m, 2H), 3.66˜3.76(m, 2H), 3.47(d, 1H, J=7.5 Hz), 1.40(s, 3H), 1.22(s, 3H), 1.22˜1.69(m, 11H), 0.86˜0.92(m, 2H); MS, m/z: 467.63 
               
               
                 5-559 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.25˜7.36(m, 2H), 6.94˜7.02(m, 2H), 6.68˜6.82(m, 3H), 4.42(d, 2H, J=2.4 Hz), 4.36(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.65˜3.73(m, 3H), 2.04˜2.47(m, 1H), 1.43(s, 3H), 1.23(s, 3H), 1.23˜1.69(m, 11H), 0.86˜0.96(m, 2H); MS, m/z: 465.61 
               
               
                 5-560 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.24˜7.38(m, 5H), 7.14(m, 2H), 6.50˜6.66(m, 3H), 4.91(d, 1H, J=11.6 Hz), 4.71(d, 1H, J= 11.6 Hz), 4.42(d, 1H, J=7.3 Hz), 4.23(s, 2H), 3.61(d, 1H, J=7.3 Hz), 3.45(s, 3H), 2.34(s, 3H), 1.40(s, 3H), 1.23(s, 3H); MS, m/z: 417.55 
               
               
                 5-561 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.26˜7.40(m, 4H), 7.00˜7.25(m, 4H), 6.54˜6.68(m, 3H), 4.87(d, 1H, J=11.4 Hz), 4.67(d, 1H, J=11.6 Hz), 4.42(d, 1H, J=7.5 Hz), 4.23(s, 2H), 3.60(d, 1H, J=7.5 Hz), 3.45(s, 3H), 2.34(s, 3H), 1.41(s, 3H), 1.23(s, 3H); MS, m/z: 435.54 
               
               
                 5-562 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-563 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.24˜7.33(m, 4H), 7.08˜7.16(m, 4H), 6.60˜6.72(m, 3H), 4.92(d, 1H, J=12.0 Hz), 4.70(d, 1H, J=12.0 Hz), 4.42(d, 1H, J=7.3 Hz), 4.23(s, 2H), 3.60(d, 1H, J=7.3 Hz), 3.45(s, 3H), 2.33(s, 3H), 1.42(s, 3H), 1.24(s, 3H); MS, m/z: 435.54 
               
               
                 5-564 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.38˜7.41(m, 3H), 7.13˜7.29(m, 7H), 6.53˜6.69(m, 3H), 4.93(d, 1H, J=11.6 Hz), 4.70(d, 1H, J=11.6 Hz), 4.42(d, 1H, J=7.3 Hz), 4.23(s, 2H), 3.64(d, 1H, J=7.3 Hz), 3.45(s, 3H), 2.37(s, 3H), 2.34(s, 3H), 1.39(s, 3H), 1.23(s, 3H); MS, m/z: 431.58 
               
               
                 5-565 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.52˜7.57(m, 1H), 7.12˜7.39(m, 7H), 6.60˜6.73(m, 3H), 5.02(d, 1H, J=12.4 Hz), 4.81(d, 1H, J=12.4 Hz), 4.44(d, 1H, J=7.3 Hz), 4.23(s, 2H), 3.67(d, 1H, J=7.3 Hz), 3.48(s, 3H), 2.33(s, 3H), 1.42(s, 3H), 1.26(s, 3H); MS, m/z: 452.00 
               
               
                 5-566 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.38˜7.39(m, 1H), 7.21˜7.30(m, 6H), 7.12˜7.16(m, 1H), 6.59˜6.70(m, 3H), 4.90(d, 1H, J= 12.0 Hz), 4.69(d, 1H, J=12.0 Hz), 4.43(d, 1H, J=7.5 Hz), 4.23(s, 2H), 3.60(d, 1H, J=7.5 Hz), 3.45(s, 3H), 2.34(s, 3H), 1.42(s, 3H), 1.24(s, 3H); MS, m/z: 452.00 
               
               
                 5-567 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.23˜7.30(m, 4H), 7.11˜7.18(m, 4H), 6.55˜6.72(m, 3H), 4.86(d, 1H, J=11.2 Hz), 4.66(d, 1H, J=11.2 Hz), 4.39(d, 1H, J=6.9 Hz), 4.22(s, 2H), 3.58(d, 1H, J=6.9 Hz), 3.47(s, 3H), 2.35(s, 3H), 2.33(s, 3H), 1.39(s, 3H), 1.22(s, 3H); MS, m/z: 431.58 
               
               
                 5-568 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.17˜7.39(m, 7H), 6.51˜6.68(m, 3H), 4.90(d, 1H, J=12.0 Hz), 4.73(d, 1H, J=12.0 Hz), 4.41(d, 1H, J=7.3 Hz), 4.23(s, 2H), 3.61(d, 1H, J=7.3 Hz), 3.46(s, 3H), 2.35(s, 3H), 1.40(s, 3H), 1.21(s, 3H); MS, m/z: 514.44 
               
               
                 5-569 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 467.61 
               
               
                 5-570 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.83(b, 3H), 7.13˜7.29(m, 4H), 6.52˜6.69(m, 3H), 5.06(d, 1H, J=12.4 Hz), 4.83(d, 1H, J= 12.4 Hz), 4.50(d, 1H, J=7.7 Hz), 4.24(s, 2H), 3.65(d, 1H, J=7.7 Hz), 3.41 (s, 3H), 2.34(s, 3H), 1.45(s, 3H), 1.26(s, 3H); MS, m/z: 445.61 
               
               
                 5-571 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 341.45 
               
               
                 5-572 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.12˜7.28(m, 4H), 6.49˜6.66(m, 3H), 4.30(d, 1H, J=7.1 Hz), 4.22(s, 2H), 3.81˜3.86(m, 1H), 3.56˜3.78(m, 2H), 3.50(s, 3H), 3.40(s, 3H), 2.34(s, 3H), 1.57˜1.61(m, 2H), 1.40(s, 3H), 1.26˜1.38(m, 4H), 1.20(s, 3H), 0.90˜0.94(m 3H); MS, m/z: 397.56 
               
               
                 5-573 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.24˜7.28(m, 2H), 7.12˜7.24(m, 2H), 6.65(d, 1H, J=3.3 Hz), 6.62(s, 1H), 6.52(dd, 1H, J=2.8 Hz, J=8.9 Hz), 5.63˜5.73(m, 2H), 4.33(d, 1H, J=7.3 Hz), 4.22(s, 2H), 4.08˜4.27(m, 2H), 3.50(d, 1H, J=7.3 Hz), 3.50(s, 3H), 2.34(s, 3H), 1.71(d, 3H, J=0.8 Hz), 1.40(s, 3H), 1.21(s, 3H); MS, m/z: 381.52 
               
               
                 5-574 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.25˜7.29(m, 2H), 7.12˜7.16(m, 2H), 6.02˜6.67(m, 3H), 5.88˜5.99(m, 1H), 5.37(dd, 1H, J= 1.6 Hz, J=17.3 Hz), 5.19(dd, 1H, J=1.4 Hz, j=10.4 Hz), 4.35(d, 1H, J=7.5 Hz), 4.23(s, 2H), 4.18˜4.36(m, 2H), 3.51(d, 1H, J= 7.5 Hz), 3.49(s, 3H), 2.34(s, 3H), 1.42(s, 3H), 1.22(s, 3H); MS, m/z: 367.49 
               
               
                 5-575 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200 MHz, CDCl 3 ) δ 7.24˜7.28(m, 2H), 7.12˜7.16(m, 2H), 6.57˜6.68(m, 3H), 4.46(d, 2H, J=2.2 Hz), 4.41(d, 1H, J=7.1 Hz), 4.22(s, 3H), 3.74(d, 1H, J=7.1 Hz), 3.46(s, 3H), 2.46(t, 1H, J=2.4 Hz), 2.34(s, 3H), 1.44(s, 3H), 1.22(s, 3H); MS, m/z: 365.48 
               
               
                 5-576 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-577 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.57 
               
               
                 5-578 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 487.69 
               
               
                 5-579 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.57 
               
               
                 5-580 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.61 
               
               
                 5-581 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 466.03 
               
               
                 5-582 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 466.03 
               
               
                 5-583 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.61 
               
               
                 5-584 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 528.47 
               
               
                 5-585 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 481.64 
               
               
                 5-586 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 567.58 
               
               
                 5-587 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 355.48 
               
               
                 5-588 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 411.59 
               
               
                 5-589 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 395.55 
               
               
                 5-590 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 381.52 
               
               
                 5-591 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 379.50 
               
               
                 5-592 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z 445.61 
               
               
                 5-593 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.60 
               
               
                 5-594 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 501.72 
               
               
                 5-595 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.60 
               
               
                 5-596 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.63 
               
               
                 5-597 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 480.05 
               
               
                 5-598 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 480.05 
               
               
                 5-599 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.63 
               
               
                 5-600 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 542.49 
               
               
                 5-601 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 495.67 
               
               
                 5-602 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 581.60 
               
               
                 5-603 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 369.51 
               
               
                 5-604 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 425.62 
               
               
                 5-605 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 409.57 
               
               
                 5-606 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 395.55 
               
               
                 5-607 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 393.53 
               
               
                 5-608 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.63 
               
               
                 5-609 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.62 
               
               
                 5-610 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 515.74 
               
               
                 5-611 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.62 
               
               
                 5-612 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-613 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 494.08 
               
               
                 5-614 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 494.08 
               
               
                 5-615 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-616 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 556.52 
               
               
                 5-617 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 509.69 
               
               
                 5-618 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 595.63 
               
               
                 5-619 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.54 
               
               
                 5-620 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 439.64 
               
               
                 5-621 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 423.60 
               
               
                 5-622 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 409.57 
               
               
                 5-623 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 407.56 
               
               
                 5-624 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 493.65 
               
               
                 5-625 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.64 
               
               
                 5-626 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 549.76 
               
               
                 5-627 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.64 
               
               
                 5-628 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 507.68 
               
               
                 5-629 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 528.10 
               
               
                 5-630 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 528.10 
               
               
                 5-631 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 507.68 
               
               
                 5-632 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 590.54 
               
               
                 5-633 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 543.71 
               
               
                 5-634 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 521.71 
               
               
                 5-635 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 417.55 
               
               
                 5-636 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-637 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 457.62 
               
               
                 5-638 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 443.59 
               
               
                 5-639 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 441.58 
               
               
                 5-640 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 507.68 
               
               
                 5-641 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 525.67 
               
               
                 5-642 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 563.79 
               
               
                 5-643 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 525.67 
               
               
                 5-644 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 521.71 
               
               
                 5-645 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 542.12 
               
               
                 5-646 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 542.12 
               
               
                 5-647 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 521.71 
               
               
                 5-648 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 604.57 
               
               
                 5-649 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 557.74 
               
               
                 5-650 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 643.68 
               
               
                 5-651 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-652 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 487.69 
               
               
                 5-653 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 471.65 
               
               
                 5-654 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 457.62 
               
               
                 5-655 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 455.60 
               
               
                 5-656 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 513.73 
               
               
                 5-657 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 531.72 
               
               
                 5-658 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 569.84 
               
               
                 5-659 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 531.72 
               
               
                 5-660 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 527.75 
               
               
                 5-661 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 548.17 
               
               
                 5-662 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 548.17 
               
               
                 5-663 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 527.75 
               
               
                 5-664 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 610.61 
               
               
                 5-665 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 563.79 
               
               
                 5-666 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 649.72 
               
               
                 5-667 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 437.63 
               
               
                 5-668 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 493.74 
               
               
                 5-669 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.69 
               
               
                 5-670 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.67 
               
               
                 5-671 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 461.65 
               
               
                 5-672 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 421.52 
               
               
                 5-673 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 439.51 
               
               
                 5-674 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.62 
               
               
                 5-675 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 439.51 
               
               
                 5-676 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.54 
               
               
                 5-677 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 455.96 
               
               
                 5-678 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 455.96 
               
               
                 5-679 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.54 
               
               
                 5-680 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 518.40 
               
               
                 5-681 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 471.58 
               
               
                 5-682 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.57 
               
               
                 5-683 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 345.42 
               
               
                 5-684 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 401.53 
               
               
                 5-685 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 385.48 
               
               
                 5-686 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 371.46 
               
               
                 5-687 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 369.44 
               
               
                 5-688 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.54 
               
               
                 5-689 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 453.53 
               
               
                 5-690 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 491.65 
               
               
                 5-691 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 453.53 
               
               
                 5-692 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.57 
               
               
                 5-693 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 469.99 
               
               
                 5-694 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 469.99 
               
               
                 5-695 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.57 
               
               
                 5-696 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 532.43 
               
               
                 5-697 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 485.60 
               
               
                 5-698 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 571.54 
               
               
                 5-699 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 359.44 
               
               
                 5-700 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 415.55 
               
               
                 5-701 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 399.51 
               
               
                 5-702 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 385.48 
               
               
                 5-703 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.47 
               
               
                 5-704 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.57 
               
               
                 5-705 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 467.56 
               
               
                 5-706 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 505.68 
               
               
                 5-707 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 467.56 
               
               
                 5-708 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.60 
               
               
                 5-709 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 484.02 
               
               
                 5-710 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 484.02 
               
               
                 5-711 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.60 
               
               
                 5-712 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 546.46 
               
               
                 5-713 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 499.63 
               
               
                 5-714 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 585.57 
               
               
                 5-715 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 373.47 
               
               
                 5-716 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 429.58 
               
               
                 5-717 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 413.54 
               
               
                 5-718 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 399.51 
               
               
                 5-719 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 397.49 
               
               
                 5-720 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.60 
               
               
                 5-721 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 481.59 
               
               
                 5-722 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 519.71 
               
               
                 5-723 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 481.59 
               
               
                 5-724 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.62 
               
               
                 5-725 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 498.04 
               
               
                 5-726 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 498.04 
               
               
                 5-727 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.62 
               
               
                 5-728 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 560.48 
               
               
                 5-729 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 513.66 
               
               
                 5-730 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 599.59 
               
               
                 5-731 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 387.50 
               
               
                 5-732 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 443.61 
               
               
                 5-733 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 427.56 
               
               
                 5-734 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 413.54 
               
               
                 5-735 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 411.52 
               
               
                 5-736 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 497.62 
               
               
                 5-737 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 515.61 
               
               
                 5-738 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 553.72 
               
               
                 5-739 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 515.61 
               
               
                 5-740 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.64 
               
               
                 5-741 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 532.06 
               
               
                 5-742 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 532.06 
               
               
                 5-743 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.64 
               
               
                 5-744 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 594.50 
               
               
                 5-745 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 547.68 
               
               
                 5-746 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 525.67 
               
               
                 5-747 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 421.52 
               
               
                 5-748 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.62 
               
               
                 5-749 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 461.58 
               
               
                 5-750 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 447.55 
               
               
                 5-751 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.54 
               
               
                 5-752 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.64 
               
               
                 5-753 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 529.63 
               
               
                 5-754 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 567.75 
               
               
                 5-755 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 529.63 
               
               
                 5-756 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 525.67 
               
               
                 5-757 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 546.09 
               
               
                 5-758 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 546.09 
               
               
                 5-759 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 525.67 
               
               
                 5-760 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 608.53 
               
               
                 5-761 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 561.70 
               
               
                 5-762 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 647.64 
               
               
                 5-763 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.54 
               
               
                 5-764 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 491.65 
               
               
                 5-765 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 475.61 
               
               
                 5-766 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 461.58 
               
               
                 5-767 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.57 
               
               
                 5-768 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 517.69 
               
               
                 5-769 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 535.68 
               
               
                 5-770 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 573.80 
               
               
                 5-771 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 535.68 
               
               
                 5-772 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 531.72 
               
               
                 5-773 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 552.14 
               
               
                 5-774 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 552.14 
               
               
                 5-775 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 531.72 
               
               
                 5-776 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 614.58 
               
               
                 5-777 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 567.75 
               
               
                 5-778 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 653.69 
               
               
                 5-779 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 441.59 
               
               
                 5-780 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 497.70 
               
               
                 5-781 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 481.66 
               
               
                 5-782 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 467.63 
               
               
                 5-783 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 465.61 
               
               
                 5-784 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 417.55 
               
               
                 5-785 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.54 
               
               
                 5-786 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-787 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.54 
               
               
                 5-788 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-789 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.00 
               
               
                 5-790 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.00 
               
               
                 5-791 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-792 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 514.44 
               
               
                 5-793 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 467.61 
               
               
                 5-794 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.61 
               
               
                 5-795 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 341.45 
               
               
                 5-796 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 397.56 
               
               
                 5-797 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 381.52 
               
               
                 5-798 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 367.49 
               
               
                 5-799 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 365.45 
               
               
                 5-800 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-801 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.57 
               
               
                 5-802 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 487.69 
               
               
                 5-803 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.57 
               
               
                 5-804 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.61 
               
               
                 5-805 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 466.03 
               
               
                 5-806 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 466.03 
               
               
                 5-807 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.61 
               
               
                 5-808 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 528.47 
               
               
                 5-809 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 481.64 
               
               
                 5-810 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 567.58 
               
               
                 5-811 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 355.48 
               
               
                 5-812 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 411.59 
               
               
                 5-813 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 395.55 
               
               
                 5-814 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 381.52 
               
               
                 5-815 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 379.50 
               
               
                 5-816 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.61 
               
               
                 5-817 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.60 
               
               
                 5-818 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 501.72 
               
               
                 5-819 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.60 
               
               
                 5-820 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.63 
               
               
                 5-821 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 480.05 
               
               
                 5-822 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 480.05 
               
               
                 5-823 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.63 
               
               
                 5-824 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 542.49 
               
               
                 5-825 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 495.67 
               
               
                 5-826 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 581.60 
               
               
                 5-827 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 369.51 
               
               
                 5-828 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 425.62 
               
               
                 5-829 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 409.57 
               
               
                 5-830 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 395.55 
               
               
                 5-831 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 393.53 
               
               
                 5-832 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.63 
               
               
                 5-833 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.62 
               
               
                 5-834 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 515.74 
               
               
                 5-835 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.62 
               
               
                 5-836 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-837 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 494.08 
               
               
                 5-838 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 494.08 
               
               
                 5-839 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-840 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 556.52 
               
               
                 5-841 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 509.69 
               
               
                 5-842 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 595.63 
               
               
                 5-843 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.54 
               
               
                 5-844 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 439.64 
               
               
                 5-845 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 423.60 
               
               
                 5-846 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 409.57 
               
               
                 5-847 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 407.56 
               
               
                 5-848 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 493.65 
               
               
                 5-849 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.64 
               
               
                 5-850 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 549.76 
               
               
                 5-851 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.64 
               
               
                 5-852 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 507.68 
               
               
                 5-853 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 528.10 
               
               
                 5-854 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 528.10 
               
               
                 5-855 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 507.68 
               
               
                 5-856 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 590.54 
               
               
                 5-857 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 543.71 
               
               
                 5-858 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 521.71 
               
               
                 5-859 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 417.55 
               
               
                 5-860 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-861 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 457.62 
               
               
                 5-862 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 443.59 
               
               
                 5-863 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 441.58 
               
               
                 5-864 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 507.68 
               
               
                 5-865 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 525.67 
               
               
                 5-866 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 563.79 
               
               
                 5-867 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 525.67 
               
               
                 5-868 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 521.71 
               
               
                 5-869 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 542.12 
               
               
                 5-870 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 542.12 
               
               
                 5-871 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 521.71 
               
               
                 5-872 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 604.57 
               
               
                 5-873 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 557.74 
               
               
                 5-874 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 643.68 
               
               
                 5-875 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.58 
               
               
                 5-876 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 487.69 
               
               
                 5-877 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 471.65 
               
               
                 5-878 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 457.62 
               
               
                 5-879 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 455.60 
               
               
                 5-880 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 513.73 
               
               
                 5-881 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 531.72 
               
               
                 5-882 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 569.84 
               
               
                 5-883 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 531.72 
               
               
                 5-884 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 527.75 
               
               
                 5-885 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 548.17 
               
               
                 5-886 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 548.17 
               
               
                 5-887 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 527.75 
               
               
                 5-888 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 610.61 
               
               
                 5-889 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 563.79 
               
               
                 5-890 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 649.72 
               
               
                 5-891 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 437.63 
               
               
                 5-892 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 493.74 
               
               
                 5-893 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.69 
               
               
                 5-894 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.67 
               
               
                 5-895 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 461.65 
               
               
                 5-896 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 437.97 
               
               
                 5-897 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 455.96 
               
               
                 5-898 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 494.08 
               
               
                 5-899 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 455.96 
               
               
                 5-900 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.00 
               
               
                 5-901 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 472.42 
               
               
                 5-902 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 472.42 
               
               
                 5-903 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.00 
               
               
                 5-904 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 543.86 
               
               
                 5-905 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 488.03 
               
               
                 5-906 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 466.03 
               
               
                 5-907 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 361.87 
               
               
                 5-908 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 417.98 
               
               
                 5-909 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 401.94 
               
               
                 5-910 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 387.91 
               
               
                 5-911 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 385.89 
               
               
                 5-912 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.00 
               
               
                 5-913 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 469.99 
               
               
                 5-914 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 508.11 
               
               
                 5-915 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 469.99 
               
               
                 5-916 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 466.03 
               
               
                 5-917 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 486.44 
               
               
                 5-918 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 486.44 
               
               
                 5-919 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 466.03 
               
               
                 5-920 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 548.88 
               
               
                 5-921 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 502.06 
               
               
                 5-922 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 587.99 
               
               
                 5-923 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 375.90 
               
               
                 5-924 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 432.01 
               
               
                 5-925 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 415.96 
               
               
                 5-926 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 401.94 
               
               
                 5-927 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 399.92 
               
               
                 5-928 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 466.03 
               
               
                 5-929 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 484.02 
               
               
                 5-930 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 522.13 
               
               
                 5-931 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 484.02 
               
               
                 5-932 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 480.05 
               
               
                 5-933 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 500.47 
               
               
                 5-934 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 500.47 
               
               
                 5-935 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 480.05 
               
               
                 5-936 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 562.91 
               
               
                 5-937 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 516.09 
               
               
                 5-938 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 602.02 
               
               
                 5-939 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 389.93 
               
               
                 5-940 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 446.03 
               
               
                 5-941 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 429.99 
               
               
                 5-942 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 415.96 
               
               
                 5-943 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 413.95 
               
               
                 5-944 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 480.05 
               
               
                 5-945 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 498.04 
               
               
                 5-946 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 536.16 
               
               
                 5-947 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 498.04 
               
               
                 5-948 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 494.08 
               
               
                 5-949 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 514.50 
               
               
                 5-950 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 494.08 
               
               
                 5-949 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 514.50 
               
               
                 5-950 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 514.50 
               
               
                 5-951 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 494.08 
               
               
                 5-952 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 576.94 
               
               
                 5-953 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 530.11 
               
               
                 5-954 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 616.05 
               
               
                 5-955 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 403.95 
               
               
                 5-956 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 460.06 
               
               
                 5-957 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 444.02 
               
               
                 5-958 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 429.99 
               
               
                 5-959 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 427.98 
               
               
                 5-960 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 514.07 
               
               
                 5-961 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 532.06 
               
               
                 5-962 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 570.18 
               
               
                 5-963 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 532.06 
               
               
                 5-964 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 528.10 
               
               
                 5-965 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 548.51 
               
               
                 5-966 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 548.51 
               
               
                 5-967 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 528.10 
               
               
                 5-968 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 610.96 
               
               
                 5-969 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 564.13 
               
               
                 5-970 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 542.12 
               
               
                 5-971 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 437.97 
               
               
                 5-972 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 494.08 
               
               
                 5-973 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 478.04 
               
               
                 5-974 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 464.01 
               
               
                 5-975 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 461.99 
               
               
                 5-976 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 528.10 
               
               
                 5-977 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 546.09 
               
               
                 5-978 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 584.21 
               
               
                 5-979 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 546.09 
               
               
                 5-980 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 542.12 
               
               
                 5-981 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 562.54 
               
               
                 5-982 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 562.54 
               
               
                 5-983 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 542.12 
               
               
                 5-984 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 624.98 
               
               
                 5-985 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 578.16 
               
               
                 5-986 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 664.09 
               
               
                 5-987 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 452.00 
               
               
                 5-988 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 508.11 
               
               
                 5-989 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 492.06 
               
               
                 5-990 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 478.04 
               
               
                 5-991 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 476.02 
               
               
                 5-992 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 534.14 
               
               
                 5-993 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 552.14 
               
               
                 5-994 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 590.25 
               
               
                 5-995 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 552.14 
               
               
                 5-996 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 548.17 
               
               
                 5-997 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 568.59 
               
               
                 5-998 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 568.59 
               
               
                 5-999 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 548.17 
               
               
                 5-1000 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 631.03 
               
               
                 5-1001 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 584.21 
               
               
                 5-1002 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 670.14 
               
               
                 5-1003 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 458.05 
               
               
                 5-1004 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 514.15 
               
               
                 5-1005 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 498.11 
               
               
                 5-1006 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 484.08 
               
               
                 5-1007 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 482.07 
               
               
                 5-1008 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.63 
               
               
                 5-1009 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.62 
               
               
                 5-1010 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 515.74 
               
               
                 5-1011 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.62 
               
               
                 5-1012 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-1013 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 494.08 
               
               
                 5-1014 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 494.08 
               
               
                 5-1015 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-1016 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 556.52 
               
               
                 5-1017 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 509.69 
               
               
                 5-1018 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 487.69 
               
               
                 5-1019 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.54 
               
               
                 5-1020 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 439.64 
               
               
                 5-1021 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 423.60 
               
               
                 5-1022 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 409.57 
               
               
                 5-1023 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 407.56 
               
               
                 5-1024 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.39˜7.28(m, 9H), 6.67˜6.54(m, 3H), 4.89(d, 1H, J=11.4 Hz), 4.71 (d, 1H, J=11.4 Hz), 4.44(d, 1H, J=7.6 Hz), 4.23(s, 2H), 3.74˜3.66(m, 2H), 3.60(d, 1H, J=7.6 Hz), 1.40(s, 3H), 1.31(s, 9H), 1.22(s, 3H), 1.19(s, 3H); MS, m/z = 431.58; MS, m/z: 473.66 
               
               
                 5-1025 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.37˜7.30(m, 6H), 7.05˜7.01(m, 2H), 6.66˜6.56(m, 3H), 4.86(d, 1H, J=11.4 Hz), 4.67(d, 1H, J=11.4 Hz), 4.43(d, 1H, J=7.6 Hz), 4.23(s, 2H), 3.70˜3.67(m, 2H), 3.58(d, 1H, J=7.6 Hz), 1.39(s, 3H), 1.31˜1.30(m, 9H), 1.21˜1.19(m, 6H); MS, m/z: 491.65 
               
               
                 5-1026 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.39˜7.30(m, 8H), 6.69˜6.57(m, 3H), 4.86(d, 1H, J=11.2 Hz), 4.68(d, 1H, J=11.2 Hz), 4.42(d, 1H, J=7.6 Hz), 4.23(s, 2H), 3.74˜3.65(d, 2H), 3.59(d, 1H, J= 7.6 Hz), 1.41(s, 3H), 1,32˜1.29(m, 18H), 1.21˜1.19(m, 6H); MS, m/z: 529.77 
               
               
                 5-1027 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.38˜7.28(m, 5H), 7.13˜7.07(m, 2H), 7.00(m, 1H), 6.69˜6.56(m, 3H), 4.91(d, 1H, J=11.8 Hz), 4.71 (d, 1H, J=11.8 Hz), 4.46(d, 1H, J=7.7 Hz), 4.23(s, 2H), 3.72˜3.67(m, 2H), 3.59(d, 1H, J=7.7 Hz), 1.42(s, 3H), 1.32(s, 9H), 1.24(s, 3H), 1.21(t, 3H, J=6.95 Hz); MS, m/z: 491.65 
               
               
                 5-1028 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.39˜7.30(m, 5H), 7.21˜7.15(m, 3H), 6.66˜6.54(m, 3H), 4.93(d, 1H, J=11.7 Hz), 4.69(d, 1H, J=11.7 Hz), 4.45(d, 1H, J=7.7 Hz), 4.23(s, 2H), 3.71˜3.64(m, 2H), 3.62(d, 1H, J=7.7 Hz), 2.35(s, 3H), 1.38(s, 3H), 1.31(s, 9H), 1.22(s, 3H), 1.19(t, 3H, t=7.0 Hz); MS, m/z: 487.69 
               
               
                 5-1029 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.54(m, 1H), 7.38˜7.22″(m, 8H), 6.70˜6.57(m, 3H), 5.04(d, 1H, J=12.7 Hz), 4.81(d, 1H, J= 12.7 Hz), 4.48(d, 1H, J=7.6 Hz), 4.24(s, 2H), 3.71(q, 2H, J=7.0 Hz), 3.67(d, 1H, J=7.7 Hz), 1.43(s, 3H), 1.33(s, 9H), 1.26(s, 3H), 1.21(t, 3H, J=7.0 Hz); MS, m/z: 508.11 
               
               
                 5-1030 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.38˜7.24(m, 8H), 6.69˜6.65(m, 2H), 6.58(m, 1H), 4.89(d, 1H, J=11.8 Hz), 4.70(d, 1H, J= 11.8 Hz), 4.46(d, 1H, J=7.8 Hz), 4.24(s, 2H), 3.68(m, 2H), 3.59(d, 1H, J=7.8 Hz), 1.42(s, 3H), 1.31 (s, 9H), 1.24(s, 3H), 1.21 (t, 3H, J=6.95 Hz); MS, m/z: 508.11 
               
               
                 5-1031 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z = 487.69 
               
               
                 5-1032 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.37˜7.20(m, 7H), 6.70˜6.55(m, 3H), 489(d, 1H, J=11.9 Hz), 4.71 (d, 1H, J=11.9 Hz), 4.42(d, 1H, J=7.7 Hz), 4.23(s, 2H), 3.72˜3.67(m, 2H), 3.59(d, 1H, J= 7.7 Hz)1.40(s, 3H), 1.30(s, 9H), 1.23˜1.19(m, 6H); MS, m/z: 570.55 
               
               
                 5-1033 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z = 523.72 
               
               
                 5-1034 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z = 609.66 
               
               
                 5-1035  
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.37˜7.30(m, 4H), 6.70˜6.54(m, 3H), 4.33(d, 1H, J=7.5 Hz), 4.23(s, 2H), 3.78˜3.70(m, 2H), 3.60(s, 3H), 3.31 (d, 1H, J=7.5 Hz), 1.41 (s, 3H), 1.31(s, 9H), 1.24(t, 3H, J=7.1 Hz), 1.19(s, 3H); MS, m/z: 398.56 
               
               
                 5-1036 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.36(d, 2H, J=8.3 Hz), 7.31(d, 2H, J=8.3 Hz), 6.70˜6.57(m, 3H), 4.32(d, 1H, J=7.7 Hz), 4.22(s, 3H), 3.82˜3.819m, 1H), 3.76˜3.72(m, 2H), 3.60˜3.58(m, 1H), 3.38(d, 1H, J=7.7 Hz), 1.62˜1.59(m, 1H), 1.40(s, 3H), 1.37˜1.28(m, 13H), 1.23(t, 3H, J=7.0 Hz), 1.19(s, 3H), 0.91(m, 3H); MS, m/z: 453.67 
               
               
                 5-1037 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.36(d, 2H, J=8.3 Hz), 7.31(d, 2H, J=8.3 Hz), 6.68˜6.56(m, 3H), 5.75˜5.61(m, 2H), 4.40˜4.34(m, 1H), 4.30˜4.23(m, 1H), 4.22(s, 2H), 4.13˜4.09(m, 1H), 3.79˜3.70(m, 2H), 3.47(d, 1H, J=7.7 Hz), 1.73˜1.68(m, 3H), 1.40(s, 3H), 1.31(s, 9H), 1.25˜1.20(m, 6H); MS, m/z = 437.63 
               
               
                 5-1038 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.36(d, 2H, J=8.4 Hz), 7.31(d, 2H, J=8.4 Hz), 6.68˜6.56(m, 3H), 6.00˜5.92(m, 1H), 5.32˜5.28(m, 1H), 5.17˜5.16(m, 1H), 4.36(d, 1H, J=7.6 Hz), 4.35˜4.34(m, 1H), 4.23(s, 2H), 4.21˜4.16(m, 1H), 3.77˜3.70(m, 2H), 3.46(d, 1H, J=7.7 Hz), 1.41(s, 3H), 1.31(s, 9H), 1.24˜1.21 (m, 6H); MS, m/z: 423.60 
               
               
                 5-1039 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(500 MHz, CDCl 3 ) δ 7.34(d, 2H, J=8.3 Hz), 7.30(d, 2H, J=8.3 Hz), 6.66˜6.56(m, 3H), 4.44(s, 2H), 4.44(d, 1H, J= 7.7 Hz), 4.22(s, 2H), 3.72˜3.67(m, 3H), 2.44(t, 1H, J=2.4 Hz), 1.43(s, 3H), 1.30(s, 9H), 1.22˜1.20(m, 6H); MS, m/z: 421.58 
               
               
                 5-1040 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 487.69 
               
               
                 5-1041 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 505.68 
               
               
                 5-1042 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 543.80 
               
               
                 5-1043 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 505.68 
               
               
                 5-1044 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 501.72 
               
               
                 5-1045 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 522.13 
               
               
                 5-1046 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 522.13 
               
               
                 5-1047 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 501.72 
               
               
                 5-1048 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 584.57 
               
               
                 5-1049 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 537.75 
               
               
                 5-1050 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m623.69/z: 
               
               
                 5-1051 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 411.59 
               
               
                 5-1052 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 467.70 
               
               
                 5-1053 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.66 
               
               
                 5-1054 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 437.63 
               
               
                 5-1055 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.61 
               
               
                 5-1056 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 501.72 
               
               
                 5-1057 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 519.71 
               
               
                 5-1058 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 557.82 
               
               
                 5-1059 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 519.71 
               
               
                 5-1060 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 515.74 
               
               
                 5-1061 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 536.16 
               
               
                 5-1062 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 536.16 
               
               
                 5-1063 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 515.74 
               
               
                 5-1064 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 598.60 
               
               
                 5-1065 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 551.78 
               
               
                 5-1066 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 637.71 
               
               
                 5-1067 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 425.62 
               
               
                 5-1068 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 481.73 
               
               
                 5-1069 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 465.68 
               
               
                 5-1070 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.66 
               
               
                 5-1071 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.64 
               
               
                 5-1072 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 535.73 
               
               
                 5-1073 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 553.72 
               
               
                 5-1074 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 591.84 
               
               
                 5-1075 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 553.72 
               
               
                 5-1076 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 549.76 
               
               
                 5-1077 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 570.18 
               
               
                 5-1078 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 570.18 
               
               
                 5-1079 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 549.76 
               
               
                 5-1080 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 632.62 
               
               
                 5-1081 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 585.79 
               
               
                 5-1082 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 563.79 
               
               
                 5-1083 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.63 
               
               
                 5-1084 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 515.74 
               
               
                 5-1085 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 499.70 
               
               
                 5-1086 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 485.67 
               
               
                 5-1087 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 483.66 
               
               
                 5-1088 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 493.65 
               
               
                 5-1089 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.64 
               
               
                 5-1090 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 549.76 
               
               
                 5-1091 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.64 
               
               
                 5-1092 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 507.68 
               
               
                 5-1093 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 528.10 
               
               
                 5-1094 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 528.10 
               
               
                 5-1095 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 507.68 
               
               
                 5-1096 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 590.54 
               
               
                 5-1097 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 543.71 
               
               
                 5-1098 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 629.65 
               
               
                 5-1099 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 417.55 
               
               
                 5-1100 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.66 
               
               
                 5-1101 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 457.62 
               
               
                 5-1102 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 443.59 
               
               
                 5-1103 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 441.58 
               
               
                 5-1104 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 555.81 
               
               
                 5-1105 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 573.80 
               
               
                 5-1106 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 611.92 
               
               
                 5-1107 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 573.80 
               
               
                 5-1108 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 569.84 
               
               
                 5-1109 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 590.25 
               
               
                 5-1110 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 590.25 
               
               
                 5-1111 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 569.84 
               
               
                 5-1112 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 652.69 
               
               
                 5-1113 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 605.87 
               
               
                 5-1114 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 691.80 
               
               
                 5-1115 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 479.71 
               
               
                 5-1116 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 535.82 
               
               
                 5-1117 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 519.77 
               
               
                 5-1118 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 505.75 
               
               
                 5-1119 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 503.73 
               
               
                 5-1120 
               
               
                   
               
            
           
         
       
     
     EXAMPLE II 
     Hydroxy Alkoxy Addition and Departure of N-methyl-substituted Olefin Resin (2a) 
                         
(II-1) Hydroxy Methoxy Addition and Departure of N-methylsubstituted Olefin Resin (2a) 
                   
     N-methyl-substituted olefin resin (200.00 mg, 0.11 mmol) of the formula (2a) was added to the mixed solution of dichloromethane (3 ml) and methanol (3 ml) and agitated for 30 min, after which metachloroperbenzoic acid (m-CPBA, 81 mg, 0.55 mmol) was added at room temperature and agitated to proceed with a reaction for 15 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (3-1) as a light yellow solid (208.6 mg). Thus obtained resin (3-1) was added to a solution of dichloromethane (5 ml) and agitated, followed by addition of 
                 
 
filtrate was washed repeatedly with CH 2 Cl 2  and MeOH. The filtrates were combined and concentrated. To the concentrates, ethylacetate (3 ml) was added, filtered thorough strong anion exchange resin (SAX resin) and washed repeatedly with ethylacetate to remove residual trifluoroacetic acid. Following concentration of the filtrate under reduced pressure, the concentrate was purified with silica gel column chromatography in the presence of hexane/ethylacetate (4/1, v/v), thereby yielding the compound of the formula (5-1121) as a light-yellow oil (16.3 mg, resin 1; from loading capacity 0.55 mmol/g, yield=63%):  1 H NMR(300 MHz, CDCl 3 ) δ(PPM) 6.69 (d, 1H, J=5.2 Hz), 6.65 (d, 1H, J=1.7 Hz), 6.58 (dd, 1H, J=5.2 Hz, J=1.7 Hz), 4.34 (d, 1H, J=4.4 Hz), 3.84 (d, 1H, J=4.4 Hz), 3.49 (s, 3H), 2.82 (s, 3H), 1.43 (s, 3H), 1.26 (s, 3H);  13 C (75 MHz) δ 145.49, 143.00, 121.33, 117.84, 115.50, 111.70, 78.16, 71.99, 55.70, 31.90, 25.68, 20.04; M/S 237.30
 
(II-2) Hydroxy Ethoxy Addition and Departure of N-methyl-substituted Olefin Resin (2a) 
                 
 
     N-methyl-substituted olefin resin (200.00 mg, 0.11 mmol) of the formula (2a) was added to the mixed solution of dichloromethane (3 ml) and ethanol (3 ml) and agitated for 30 min, after which metachloroperbenzoic acid (m-CPBA, 81 mg, 0.55 mmol) was added at room temperature and agitated to proceed with a reaction for 15 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (3-2) as a light yellow solid (207.4 mg). Thus obtained resin (3-2) was added to a solution of dichloromethane (5 ml) and agitated, followed by addition of trifluoroacetic acid (TFA, 1 ml) and agitation for 4 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and the filtrate was washed repeatedly with CH 2 Cl 2  and MeOH. The filtrates were combined and concentrated. To the concentrates, ethylacetate (3 ml) was added, filtered thorough strong anion exchange resin (SAX resin) and washed repeatedly with ethylacetate to remove residual trifluoroacetic acid. Following concentration of the filtrate under reduced pressure, the concentrate was purified with silica gel column chromatography in the presence of hexane/ethylacetate (4/1, v/v), giving the compound of the formula (5-1121) as a light-yellow oil (16.7 mg, resin 1; from loading capacity 0.55 mmol/g, yield=60%):  1 H NMR (200 MHz, CDCl 3 ) δ (PPM) 6.70-6.50 (m, 3H), 4.36 (d, 1H, J=7.4 Hz), 3.82-3.67 (m, 3H), 2.81 (s, 3H), 1.43 (s, 3H), 1.32-1.25 (m, 61); M/S 251.33
 
(II-3) Hydroxy 2-propoxy Addition and Departure of N-methyl-substituted Olefin Resin (2a) 
                 
 
     N-methyl-substituted olefin resin (200.00 mg, 0.11 mmol) of the formula (2a) was added to the mixed solution of dichloromethane (3 ml) and 2-propanol (3 ml) and agitated for 30 min, after which metachloroperbenzoic acid (m-CPBA, 81 mg, 0.55 mmol) was added at room temperature and agitated to proceed with a reaction for 15 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (3-3) as a light yellow solid (206.8 mg). Thus obtained resin (3-3) was added to a solution of dichloromethane (5 ml) and agitated, followed by addition of trifluoroacetic acid (TFA, 1 ml) and agitation for 4 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and the filtrate was washed repeatedly with CH 2 Cl 2  and MeOH. The filtrates were combined and concentrated. To the concentrates, ethylacetate (3 ml) was added, filtered thorough strong anion exchange resin (SAX resin) and washed repeatedly with ethylacetate to remove residual trifluoroacetic acid. Following concentration of the filtrate under reduced pressure, the concentrate was purified with silica gel column chromatography in the presence of hexane/ethylacetate (4/1, v/v), giving the compound of the formula (5-1123) as a light-yellow oil (14.8 mg, resin 1; from loading capacity 0.55 mmol/g, yield=56%): M/S 265.36
 
(II-4) Hydroxy 2-butoxy Addition and Departure of N-methyl-substituted Olefin Resin (2a) 
                 
 
     N-methyl-substituted olefin resin (200.00 mg, 0.11 mmol) of the formula (2a) was added to the mixed solution of dichloromethane (3 ml) and butanol (3 ml) and agitated for 30 min, after which metachloroperbenzoic acid (m-CPBA, 81 mg, 0.55 mmol) was added at room temperature and agitated to proceed with a reaction for 15 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (3-4) as a light yellow solid (208.3 mg). Thus obtained resin (3-4) was added to a solution of dichloromethane (5 ml) and agitated, followed by addition of trifluoroacetic acid (TFA, 1 ml) and agitation for 4 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and the filtrate was washed repeatedly with CH 2 Cl 2  and MeOH. The filtrates were combined and concentrated. To the concentrates, ethylacetate (3 ml) was added, filtered thorough strong anion exchange resin (SAX resin) and washed repeatedly with ethylacetate to remove residual trifluoroacetic acid. Following concentration of the filtrate under reduced pressure, the concentrate was purified with silica gel column chromatography in the presence of hexane/ethylacetate (4/1, v/v), thereby yielding the compound of the formula (5-1124) as a light-yellow oil (19.1 mg, resin 1; from loading capacity 0.55 mmol/g, yield=62%):  1 H NMR (200 MHz, CDCl 3 ) δ (PPM) 6.70-6.50 (m, 3H), 4.35 (d, 1H, J=7.2 Hz), 3.80 (d, 1H, J=7.2 Hz) 3.67 (t, 2H, J=6.2 Hz), 2.81 (s, 3H), 1.67-1.53 (m, 2H), 1.49-1.30 (m, 2H), 1.42 (s, 3H), 1.25(s, 3H), 0.94 (t, 3H, J=7.2 Hz); M/S 279.38 
     The 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives synthesized according to the method of parallel synthesis on the solid-phase as Example II are summarized in Table 2. 
     In construction of the library in Table 2, the following precursors were employed to preparing combinations of each substituent: for example, R 1  precursor includes CH 3 I, C 2 H 5 I, tBuI, 4-BuI, 4-F—C 4 H 9 I, 4-Me-C 4 H 9 I, 2-CH 3 -C 4 H 9 I, 3-Cl—C 4 H 9 I, 4-tBu-C 4 H 9 I and 3-F—C 4 H 9 I; R 2  precursor includes CH 3 OH, C 2 H 5 OH, iPrOH, tBuOH, C 4 H 9 OH, 2-Ph-EtOH and 2-cyclohexyl-EtOH. 
     
       
         
           
               
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                   
                 (5) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
            
           
           
               
               
               
               
            
               
                 Compound 
                   
                   
                   
               
               
                 No. 
                 R 1   
                 R 2   
                 NMR/MS Data 
               
               
                   
               
               
                 5-1121 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                 5-1122 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                 5-1123 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                 5-1124 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                 5-1125 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 307.44 
               
               
                 5-1126 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.70˜6.52(m, 3H), 4.34(d, 1H, J=7.0Hz), 3.80(d, 1H, J=7.0Hz), 3.70(t, 2H, J=6.6Hz), 2.81(s, 3H), 1.75˜0.94(m, 19H); M/S 333.47 
               
               
                 5-1127 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 333.47 
               
               
                 5-1128 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 279.38 
               
               
                 5-1129 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 307.44 
               
               
                 5-1130 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 293.41 
               
               
                 5-1131 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.44˜7.28(m, 5H), 6.78˜6.69(m, 3H), 4.76(s, 2H), 4.48(d, 1H, J=7.0Hz), 3.85(d, 1H, J=7.0Hz), 2.78(s, 3H), 1.44(s, 3H), 1.27(s, 3H); M/S 313.40 
               
               
                 5-1132 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 331.39 
               
               
                 5-1133 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 343.43 
               
               
                 5-1134 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 327.43 
               
               
                 5-1135 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 327.43 
               
               
                 5-1136 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 345.41 
               
               
                 5-1137 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.51 
               
               
                 5-1138 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 341.45 
               
               
                 5-1139 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 349.38 
               
               
                 5-1140 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 358.39 
               
               
                 5-1141 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 251.33 
               
               
                 5-1142 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 265.36 
               
               
                 5-1143 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 279.38 
               
               
                 5-1144 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 293.40 
               
               
                 5-1145 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 321.46 
               
               
                 5-1146 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 347.50 
               
               
                 5-1147 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 347.50 
               
               
                 5-1148 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 293.41 
               
               
                 5-1149 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 321.46 
               
               
                 5-1150 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 307.44 
               
               
                 5-1151 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 327.43 
               
               
                 5-1152 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 345.42 
               
               
                 5-1153 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 357.45 
               
               
                 5-1154 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 341.45 
               
               
                 5-1155 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 341.45 
               
               
                 5-1156 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 359.44 
               
               
                 5-1157 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 383.54 
               
               
                 5-1158 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 355.48 
               
               
                 5-1159 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 363.41 
               
               
                 5-1160 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 372.42 
               
               
                 5-1161 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 265.36 
               
               
                 5-1162 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 279.38 
               
               
                 5-1163 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 293.41 
               
               
                 5-1164 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 307.44 
               
               
                 5-1165 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 335.49 
               
               
                 5-1166 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 361.53 
               
               
                 5-1167 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 361.53 
               
               
                 5-1168 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 307.44 
               
               
                 5-1169 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 335.49 
               
               
                 5-1170 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 321.46 
               
               
                 5-1171 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 341.45 
               
               
                 5-1172 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 359.44 
               
               
                 5-1173 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 371.48 
               
               
                 5-1174 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 355.48 
               
               
                 5-1175 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 355.48 
               
               
                 5-1176 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 373.47 
               
               
                 5-1177 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 397.56 
               
               
                 5-1178 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.50 
               
               
                 5-1179 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 377.44 
               
               
                 5-1180 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 386.45 
               
               
                 5-1181 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 279.38 
               
               
                 5-1182 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 293.41 
               
               
                 5-1183 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 307.44 
               
               
                 5-1184 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 321.46 
               
               
                 5-1185 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 349.52 
               
               
                 5-1186 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 375.56 
               
               
                 5-1187 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 375.56 
               
               
                 5-1188 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 321.46 
               
               
                 5-1189 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 349.52 
               
               
                 5-1190 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 335.49 
               
               
                 5-1191 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 335.48 
               
               
                 5-1192 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 373.47 
               
               
                 5-1193 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 385.51 
               
               
                 5-1194 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.51 
               
               
                 5-1195 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.51 
               
               
                 5-1196 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 387.49 
               
               
                 5-1197 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 411.59 
               
               
                 5-1198 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 383.54 
               
               
                 5-1199 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 391.46 
               
               
                 5-1200 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 400.48 
               
               
                 5-1201 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 293.41 
               
               
                 5-1202 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 307.44 
               
               
                 5-1203 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 321.46 
               
               
                 5-1204 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 335.49 
               
               
                 5-1205 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 363.55 
               
               
                 5-1206 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 389.58 
               
               
                 5-1207 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 389.58 
               
               
                 5-1208 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 335.49 
               
               
                 5-1209 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 363.55 
               
               
                 5-1210 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 349.52 
               
               
                 5-1211 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.51 
               
               
                 5-1212 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 387.49 
               
               
                 5-1213 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 399.53 
               
               
                 5-1214 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 383.54 
               
               
                 5-1215 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 383.54 
               
               
                 5-1216 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 401.53 
               
               
                 5-1217 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 425.62 
               
               
                 5-1218 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 397.56 
               
               
                 5-1219 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 405.49 
               
               
                 5-1220 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 414.51 
               
               
                 5-1221 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl δ 7.36(m, 4H), 7.28(d, 1H, J=4.3Hz), 6.67(m, 2H), 6.57(dd, 1H, J=5.2Hz J=1.7Hz), 4.31(d, 1H, J=4.5Hz), 4.28(s, 2H), 3.82(d, 1H, J=4.5Hz), 3.82(d, 1H, J=4.4Hz), 3.41 (s, 3H), 1.43(s, 3H), 1.25(s, 3H); M/S 313.40 
               
               
                 5-1222 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 327.43 
               
               
                 5-1223 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.40˜7.24(m, 5H), 6.67˜6.50(m, 3H), 4.70(s, 2H), 6.27(d, 1H, J=6.6Hz), 4.01˜3.95(m, 1H), 3.67(d, 1H, J=6.6Hz), 1.40(s, 2H), 1.29˜1.22(m, 10H); M/S 341.45 
               
               
                 5-1224 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 355.48 
               
               
                 5-1225 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 383.54 
               
               
                 5-1226 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.28(m, 5H), 7.00(d, 1H, J=2.5Hz), 6.87(dd, 1H, J=8.7Hz, J=2.5Hz), 6.68(d, 1H, J=8.7Hz), 4.23(d, 1H, J=7.0Hz), 4.23(s, 2H), 3.73(d, 1H, J=7.0Hz), 3.66(td, 2H, J=6.84Hz, J=3.36Hz), 1.72˜1.63(m, 5H), 1.50(td, 2H, J=6.84Hz, J=6.77Hz), 1.41 (s, 3H), 1.25(s, 3H), 1.21˜1.17(m, 4H), 0.92(m, 2H); M/S 409.57 
               
               
                 5-1227 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 409.57 
               
               
                 5-1228 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 355.48 
               
               
                 5-1229 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 383.54 
               
               
                 5-1230 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.51 
               
               
                 5-1231 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.37˜7.25(m, 10H), 6.65˜6.56(m, 3H), 4.68(s, 2H), 4.48(d, 1H, J=7.4Hz), 4.23(s, 2H), 3.86(d, 1H, J=7.4 Hz), 1.43(s, 3H), 1.25(s, 3H); M/S 389.49 
               
               
                 5-1232 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 407.49 
               
               
                 5-1233 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 419.53 
               
               
                 5-1234 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 403.53 
               
               
                 5-1235 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 403.53 
               
               
                 5-1236 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 421.52 
               
               
                 5-1237 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 445.60 
               
               
                 5-1238 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 417.55 
               
               
                 5-1239 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 425.47 
               
               
                 5-1240 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 434.49 
               
               
                 5-1241 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 327.42 
               
               
                 5-1242 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 341.45 
               
               
                 5-1243 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 355.48 
               
               
                 5-1244 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.50 
               
               
                 5-1245 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 397.56 
               
               
                 5-1246 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 423.60 
               
               
                 5-1247 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 423.60 
               
               
                 5-1248 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.50 
               
               
                 5-1249 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 397.56 
               
               
                 5-1250 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 383.53 
               
               
                 5-1251 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 403.52 
               
               
                 5-1252 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 421.51 
               
               
                 5-1253 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 433.55 
               
               
                 5-1254 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 431.58 
               
               
                 5-1255 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 417.55 
               
               
                 5-1256 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 435.54 
               
               
                 5-1257 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 459.63 
               
               
                 5-1258 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 431.58 
               
               
                 5-1259 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 439.50 
               
               
                 5-1260 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 448.52 
               
               
                 5-1261 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.26(d, 2H, J=4.8Hz), 7.14(d, 2H, J=4.8Hz), 6.67(d, 1H, J=5.2Hz, J=1.7Hz), 6.65(d, 1H, J=1.7Hz), 6.56(dd, 1H, J=5.2Hz, J=1.7Hz), 4.31(d, 1H, J=4.4Hz), 4.23(s, 2H), 3.82(d, 1H, J=4.4Hz), 3.43(s, 3H), 2.34(s, 3H), 1.43(s, 9H), 1.25(s, 3H);  13 C(75 MHz) δ 145.33, 142.20, 136.89, 136.27, 129.25, 127.71, 121.28, 117.81, 115.56,  
               
               
                 # 111.94, 78.13, 72.00, 55.62, 49.16 25.74, 21.08, 20.00, M/S 327.42 
               
               
                 5-1262 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 341.45 
               
               
                 5-1263 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 355.48 
               
               
                 5-1264 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.50 
               
               
                 5-1265 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 397.56 
               
               
                 5-1266 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 423.60 
               
               
                 5-1267 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 423.60 
               
               
                 5-1268 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.50 
               
               
                 5-1269 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 397.56 
               
               
                 5-1270 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 383.53 
               
               
                 5-1271 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 403.52 
               
               
                 5-1272 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 421.51 
               
               
                 5-1273 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 433.55 
               
               
                 5-1274 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 431.58 
               
               
                 5-1275 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 417.55 
               
               
                 5-1276 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 435.54 
               
               
                 5-1277 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 459.63 
               
               
                 5-1278 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 431.58 
               
               
                 5-1279 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 439.50 
               
               
                 5-1280 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 448.52 
               
               
                 5-1281 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.37(d, 2H, J=5.0Hz), 7.31(d, 2H, J=5.0Hz), 6.67(d, 1H, J=5.2Hz, J=1.7Hz), 6.65(d, 1H, J=1.7Hz), 6.58(dd, 1H, J=5.2Hz, J=1.7Hz), 4.31(d, 1H, J=4.5Hz), 4.24(s, 2H), 3.82(d, 1H, J=4.5), 3.41 (s, 3H), 1.43(s, 3H), 1.32(s, 9H), 1.25(s, 3H); —C(75 MHz) δ 150.26, 145.39, 142.20, 136.21, 127.56, 125.49, 121.24, 117.83, 115.67, 111.98, 78.10, 71.96, 55.51, 49.13,  
               
               
                 # 34.49, 31.35, 25.75, 19.98; M/S 369.50 
               
               
                 5-1282 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.40(d, 1H, J=4.9 Hz), 7.37(d, 2H, J=4.9Hz), 7.31(d, 2H, J=4.9 Hz), 6.66(d, 1H, J=5.2Hz), 6.65(d, 1H, J=1.5 Hz), 6.57(dd, 1H, J=5.2Hz, J=1.5Hz), 4.33(d, 1H, J=4.5Hz), 4.23(s, 2H), 3.78(d, 1H, J=4.5 Hz), 3.65(qd, 2H, J=4.2Hz, J=1.8Hz), 1.43(s, 3H), 1.31 (s, 3H), 1.24(s, 3H), 1.20(t, 3H, J=4.2 Hz); M/S 383.53 
               
               
                 5-1283 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 397.56 
               
               
                 5-1284 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 411.58 
               
               
                 5-1285 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 439.64 
               
               
                 5-1286 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 465.68 
               
               
                 5-1287 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 465.68 
               
               
                 5-1288 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 411.58 
               
               
                 5-1289 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 439.64 
               
               
                 5-1290 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 425.61 
               
               
                 5-1291 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 445.60 
               
               
                 5-1292 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 463.59 
               
               
                 5-1293 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 475.63 
               
               
                 5-1294 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 473.66 
               
               
                 5-1295 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 459.63 
               
               
                 5-1296 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 477.62 
               
               
                 5-1297 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 501.71 
               
               
                 5-1298 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 473.66 
               
               
                 5-1299 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 481.58 
               
               
                 5-1300 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 490.60 
               
               
                 5-1301 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.33(m, 2H), 7.01(m, 2H), 6.67(d, 1H, J=5.1Hz), 6.63(d, 1H, J=1.7Hz), 6.55(dd, 1H, J=5.1Hz, J=1.7Hz), 4.30(d, 1H, J=4.5Hz), 4.25(s, 2H), 3.81(d, 1H, J=4.5Hz), 3.42(s, 3H), 1.43(s, 3H), 1.24(s, 3H); M/S 331.39 
               
               
                 5-1302 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 345.41 
               
               
                 5-1303 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.34(dd, 2H, J=4.9 Hz, J=3.4Hz), 7.01(t, 2H, J=5.2Hz), 6.65(m, 2H), 6.60(d, 1H, J=5.3Hz), 4.26(d, 1H, J=4.1 Hz), 4.24(s, 2H), 3.97(m, 1H), 3.66(d, 1H, J=4.1Hz), 1.40(s, 3H), 1.28(s, 3H), 1.26(d, 3H, J=3.6Hz), 1.23(d, 3H, J=3.7Hz); M/S 359.44 
               
               
                 5-1304 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.30˜7.28(m, 2H), 6.98˜6.94(m, 2H), 6.90(s, 1H), 6.81(d, 1H, J=5.4Hz), 6.69(d, 1H, J=5.4Hz), 4.25(d, 1H, J=4.3Hz), 4.23(s, 2H), 3.76(d, 1H, J=4.3Hz), 3.62(t, 2H, J=3.2Hz), 1.58(m, 2H), 1.44˜1.35(m, 5H), 1.26(s, 3H), 0.94(t, 3H, J=4.4Hz); M/S 373.47 
               
               
                 5-1305 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 401.52 
               
               
                 5-1306 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.33(ddd, 2H, J=8.6Hz, J=2.1Hz), 7.01(ddd, 2H, J=8.6Hz, J=2.1Hz), 6.66(d, 1H, J=8.7Hz), 6.64(d, 1H, J=2.8Hz), 6.56(dd, 1H, J=8.7Hz, J=2.8), 4.29(d, 1H, J=7.4Hz), 4.24(s, 2H), 3.84(d, 1H, J=7.4Hz), 3.63(t, 2H, J=6.7Hz), 1.71˜1.67(m, 4H), 1.52˜1.18(m, 8H), 1.42(s, 3H), 1.24(s, 3H), 0.92(m, 1H); M/S 427.56 
               
               
                 5-1307 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 427.56 
               
               
                 5-1308 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 373.47 
               
               
                 5-1309 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 401.52 
               
               
                 5-1310 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 387.49 
               
               
                 5-1311 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 407.48 
               
               
                 5-1312 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 425.47 
               
               
                 5-1313 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 437.51 
               
               
                 5-1314 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 435.54 
               
               
                 5-1315 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.39˜7.17(m, 7H), 7.00(t, 2H, J=8.7Hz), 6.62(d, 1H, J=8.7Hz), 6.54(dd, 1H, J=8.7Hz, J=2.7Hz), 6.31(d, 1H, J=2.7Hz), 4.27(d, 1H, J=7.8Hz), 4.15(s, 2H), 3.89˜3.76(m, 2H), 3.65(d, 1H, J=7.8Hz), 2.88(dd, 2H, 6.6??), 1.35(s, 3H), 1.16(s, 3H); M/S 421.51 
               
               
                 5-1316 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 439.50 
               
               
                 5-1317 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 463.59 
               
               
                 5-1318 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 435.54 
               
               
                 5-1319 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 443.47 
               
               
                 5-1320 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 452.48 
               
               
                 5-1321 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.29(m, 1H), 7.15(d, 1H, J=4.6Hz), 7.09(m, 1H), 6.95(ddd, 1H, J=5.0Hz, J=1.5Hz), 6.67(d, 1H, J=5.2Hz), 6.65(d, 1H, J=1.7Hz), 6.57(dd, 1H, J=5.2Hz, J=1.7Hz), 4.30(d, 1H, J=4.5Hz), 4.29(s, 2H), 3.81 (d, 1H, J=4.5Hz), 3.41(s, 3H), 1.43(s, 3H), 1.25(s, 3H); M/S 345.41 
               
               
                 5-1322 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 331.39 
               
               
                 5-1323 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.34(dd, 2H, J=4.9, J=3.4Hz), 7.01(t, 2H, J=5.2Hz), 6.65(m, 2H), 6.60(d, 1H, J=5.3Hz), 4.26(d, 1H, J=4.1Hz), 4.24(s, 2H), 3.97(m, 1H), 3.66(d, 1H, J=4.1Hz), 1.40(s, 3H), 1.28(s, 3H), 1.26(d, 3H, J=3.6Hz), 1.23(d, 3H, J=3.7Hz), M/S 359.44 
               
               
                 5-1324 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 373.47 
               
               
                 5-1325 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 401.52 
               
               
                 5-1326 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 427.56 
               
               
                 5-1327 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 427.56 
               
               
                 5-1328 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 373.47 
               
               
                 5-1329 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 401.52 
               
               
                 5-1330 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 387.49 
               
               
                 5-1331 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 407.48 
               
               
                 5-1332 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 425.47 
               
               
                 5-1333 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 437.51 
               
               
                 5-1334 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 435.54 
               
               
                 5-1335 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 421.51 
               
               
                 5-1336 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 439.50 
               
               
                 5-1337 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 463.59 
               
               
                 5-1338 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 435.54 
               
               
                 5-1339 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 443.47 
               
               
                 5-1340 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 452.48 
               
               
                 5-1341 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 341.45 
               
               
                 5-1342 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 355.48 
               
               
                 5-1343 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.50 
               
               
                 5-1344 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 383.53 
               
               
                 5-1345 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 411.58 
               
               
                 5-1346 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 437.62 
               
               
                 5-1347 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 437.62 
               
               
                 5-1348 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 383.53 
               
               
                 5-1349 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 411.58 
               
               
                 5-1350 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 397.56 
               
               
                 5-1351 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 417.55 
               
               
                 5-1352 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 435.54 
               
               
                 5-1353 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 447.57 
               
               
                 5-1354 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 445.60 
               
               
                 5-1355 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 431.58 
               
               
                 5-1356 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 449.57 
               
               
                 5-1357 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 473.66 
               
               
                 5-1358 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 445.60 
               
               
                 5-1359 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 453.53 
               
               
                 5-1360 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 462.55 
               
               
                 5-1361 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 410.28 
               
               
                 5-1362 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 424.31 
               
               
                 5-1363 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 438.34 
               
               
                 5-1364 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 452.36 
               
               
                 5-1365 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 480.42 
               
               
                 5-1366 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 506.46 
               
               
                 5-1367 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 506.46 
               
               
                 5-1368 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 452.36 
               
               
                 5-1369 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 480.42 
               
               
                 5-1370 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 466.39 
               
               
                 5-1371 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 486.38 
               
               
                 5-1372 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 504.37 
               
               
                 5-1373 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 516.41 
               
               
                 5-1374 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 514.43 
               
               
                 5-1375 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 500.41 
               
               
                 5-1376 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 518.40 
               
               
                 5-1377 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 542.49 
               
               
                 5-1378 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 514.43 
               
               
                 5-1379 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 522.36 
               
               
                 5-1380 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 531.38 
               
               
                 5-1381 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 363.46 
               
               
                 5-1382 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 377.48 
               
               
                 5-1383 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 391.51 
               
               
                 5-1384 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 405.54 
               
               
                 5-1385 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 433.59 
               
               
                 5-1386 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 459.63 
               
               
                 5-1387 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 459.63 
               
               
                 5-1388 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 405.54 
               
               
                 5-1389 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 433.59 
               
               
                 5-1390 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 419.56 
               
               
                 5-1391 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 439.55 
               
               
                 5-1392 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 457.54 
               
               
                 5-1393 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 469.58 
               
               
                 5-1394 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 453.58 
               
               
                 5-1395 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 453.58 
               
               
                 5-1396 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 471.57 
               
               
                 5-1397 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 495.66 
               
               
                 5-1398 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 467.61 
               
               
                 5-1399 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 475.54 
               
               
                 5-1400 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 484.55 
               
               
                 5-1401 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 327.42 
               
               
                 5-1402 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 341.45 
               
               
                 5-1403 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 355.48 
               
               
                 5-1404 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.50 
               
               
                 5-1405 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 397.56 
               
               
                 5-1406 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 423.60 
               
               
                 5-1407 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 423.60 
               
               
                 5-1408 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.50 
               
               
                 5-1409 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 397.56 
               
               
                 5-1410 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 383.53 
               
               
                 5-1411 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 403.52 
               
               
                 5-1412 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 421.51 
               
               
                 5-1413 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 433.55 
               
               
                 5-1414 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 417.55 
               
               
                 5-1415 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 417.55 
               
               
                 5-1416 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 435.54 
               
               
                 5-1417 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 459.63 
               
               
                 5-1418 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 431.58 
               
               
                 5-1419 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 439.50 
               
               
                 5-1420 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 448.52 
               
               
                 5-1421 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.27(d, 2H, J=8.6Hz), 6.87(d, 2H, J=8.6Hz), 6.67(d, 1H, J=8.7Hz), 6.64(d, 1H, J=2.8Hz), 6.53(dd, 1H, J=8.7Hz, J=2.8Hz), 4.31(d, 1H, J=7.3Hz), 3.81(d, 1H, J=7.3Hz), 3.80(s, 3H), 3.43(s, 3H), 1.43(s, 3H), 1.24(s, 3H); M/S 343.42 
               
               
                 5-1422 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.29(d, 2H, J=8.6Hz), 6.87(d, 2H, J=8.6Hz), 6.67(d, 1H, J=8.7Hz), 6.64(d, 1H, J=2.8Hz), 6.56(dd, 1H, J=8.7Hz, J=2.8Hz), 4.33(d, 1H, J=8.4Hz), 3.20(d, 1H, J=7.3Hz), 3.80(d, 3H), 3.78(d, 1H, J=8.4Hz), 3.66(m, 2H), 1.43(s, 3H), 1.24(s, 3H), 1.22(s, 3H); M/S 357.45 
               
               
                 5-1423 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.28(d, 2H, J=8.6Hz), 6.85(d, 2H, J=8.6Hz), 6.65(br, 2H), 6.75(s, 1H), 4.26(d, 1H, J=6.6Hz), 4.19(s, 2H), 3.98(m, 1H), 3.78(s, 3H), 3.66(d, 1H, J=6.6Hz), 1.40˜1.23(m, 12H); M/S 371.48 
               
               
                 5-1424 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.27(d, 2H, J=8.6Hz), 6.83(d, 2H, J=8.6Hz), 6.70(m, 3H), 4.28(d, 1H, J=7.1Hz), 4.20(s, 2H), 3.77(s, 3H), 3.76(d, 1H, J=7.1Hz), 3.61(t, 2H, J=6.6Hz), 1.58(m, 2H), 1.38(m, 2H), 1.42(s, 3H), 1.25(s, 3H), 0.93(d, 3H, J=7.3Hz); M/S 385.50 
               
               
                 5-1425 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 413.56 
               
               
                 5-1426 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.28(d, 2H, J=8.6Hz), 6.83(d, 2H, J=8.6Hz), 6.77(m, 3H), 4.28(d, 1H, J=7.1Hz), 4.19(s, 2H), 3.78(d, 1H, J=7.1Hz), 3.78(s, 3H), 3.66(t, 2H, J=6.7Hz), 1.48(s, 3H), 1.26(s, 3H), 1.72˜0.90(m, 13H); M/S 439.60 
               
               
                 5-1427 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 439.60 
               
               
                 5-1428 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 385.50 
               
               
                 5-1429 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 413.56 
               
               
                 5-1430 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 399.53 
               
               
                 5-1431 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300MHz, CDCl 3 ) δ 7.38˜7.24(m, 7H), 6.83(d, 2H, J=8.7Hz), 6.72˜6.64(m, 3H), 4.68(s, 2H), 4.45(d, 1H, J=7.1Hz), 4.15(s, 2H), 3.85(d, 1H, J=7.1Hz), 3.76(s, 2H), 1.43(s, 3H), 1.25(s, 3H); M/S 419.52 
               
               
                 5-1432 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 437.51 
               
               
                 5-1433 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 449.55 
               
               
                 5-1434 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 433.55 
               
               
                 5-1435 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(300 MHZ, CDCl 3 ) δ 7.27(m, 6H), 7.17(t, 1H, J=7.2Hz), 6.88(d, 2H, J=8.7Hz), 6.52(dd, 1H, J=8.7Hz, J=2.8Hz), 6.38(d, 1H, J=2.8Hz), 4.30(d, 1H, J=7.8Hz), 4.12(s, 2H), 3.83(m, 2H), 3.79(s, 3H), 3.67(d, 1H, J=7.8Hz), 2.89(t, 2H, J=6.5Hz), 1.36(s, 3H), 1.17(s, 3H); M/S 433.55 
               
               
                 5-1436 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 451.54 
               
               
                 5-1437 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 475.63 
               
               
                 5-1438 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 447.57 
               
               
                 5-1439 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 455.50 
               
               
                 5-1440 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 464.52 
               
               
                 5-1441 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 381.39 
               
               
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                 M/S 395.42 
               
               
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                 M/S 409.45 
               
               
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                 M/S 423.47 
               
               
                 5-1445 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 451.53 
               
               
                 5-1446 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
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                 5-1447 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
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                 M/S 423.47 
               
               
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                 5-1450 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
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                 M/S 513.60 
               
               
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                 M/S 485.55 
               
               
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                 M/S 493.47 
               
               
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                 M/S 355.48 
               
               
                 5-1462 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 369.50 
               
               
                 5-1463 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 383.53 
               
               
                 5-1464 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 M/S 397.56 
               
               
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                 M/S 425.61 
               
               
                 5-1466 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
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                 M/S 397.56 
               
               
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                 M/S 476.57 
               
               
                   
               
            
           
         
       
     
     EXAMPLE III 
     Synthesis of 2,2-dimethyl-3-acetylester-4-methoxy-6-methylamino Benzopyran 
     (III-1) N-methylation of Olefin Resin (Formula 1) 
                 
 
     Carbamate resin having benzopyran structure of the formula (1) (200.00 mg, 0.11 mmol) was added to dimethylsulfoxide (DMSO; 3 ml) and agitated for 10 min at room temperature, followed by adding 1 M lithium t-butoxide solution (LiOtBu)(0.36 ml, 0.36 mmol) and agitating for 20 min at the same temperature. To the mixture, iodomethane (MeI; 0.051 ml, 0.36 mmol) was added and agitated to proceed with a reaction for 15 hr at 35° C. Upon completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding N-4-methyl substituted carbamate resin of the formula (2a) as light brown-colored solid (ATR-FTIR: N-methylation carbamate, 1700 cm −1 )
 
(III-2) Addition of Hydroxy Methoxy to N-methyl-substituted Olefin Resin (Formula 2a) 
                 
 
     N-methyl-substituted carbamate resin (200 mg, 0.12 mmol) of the formula (2a) was added to the mixed solution of dichloromethane (3 ml) and methanol (3 ml) and agitated for 30 min, after which metachloroperbenzoic acid (m-CPBA, 103 mg, 0.60 mmol) was added at room temperature and agitated to proceed with a reaction for 12 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (3a) as a light yellow solid.
 
(111-3) Esterification of N-methyl-substituted Hydroxyl Methoxy Resin (Formula 3a) 
                 
 
     2,2-dimethyl-3-hydroxy-4-methoxy-6-methyl amino benzopyran resin (200 mg, 0.12 mmol) linked to a carbamate linker represented by the formula (3a) was added to a solution of dichloromethane (3 ml) and agitated for 10 min at room temperature, followed by adding pyridine (0.136 ml, 1.68 mmol) and agitating for 30 min to proceed a reaction. To the mixture, acetyl chloride (0.119 ml, 1.68 mmol) and 4-dimethylaminopyridine (0.0137 g, 0.112 mmol) were added and allowed reaction for 12 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (4a) as a light brown solid.
 
(III-4) Departure Reaction of N-methyl-substituted Ester Methoxy Resin (Formula 4a) 
                 
 
     The resin (200 mg) of the formula (4a) was added to a solution of dichloromethane (4 ml) and agitated, followed by addition of trifluoroacetic acid (TFA, 1 ml) and agitation for 3 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and the filtrate was washed repeatedly with dichloromethane and methyl alcohol. The filtrates were combined and concentrated. To the concentrates, ethylacetate (3 ml) was added, filtered thorough strong anion exchange resin (SAX) and washed repeatedly with ethylacetate to remove residual TFA. Following concentration of the filtrate under reduced pressure, the concentrate was purified with silica gel column chromatography in the presence of hexane/ethylacetate (4/1, v/v), giving the compound of the formula (5-1481) as light-yellow oil (17.42 mg, yield=51.97%; 4 step overall yield from resin 1; loading capacity of resin 1=0.55 mmol/g). 
     The 2,2-dimethyl-3-ester-4-alkoxy-6-alkyl amino benzopyran derivatives synthesized according to the method of parallel synthesis on the solid-phase as Example III are summarized in Table 3. 
     In construction of the library in Table 3, the following precursors were employed to preparing combinations of each substituent: for example, R 1  precursor includes MeI, EtI, BnBr, 4-MeO-BnCl, 4-Fe-BnBr and 4-Me-BnBr; R 2  precursor includes MeOH, EtOH,  i PrOH,  i BuOH, BnOH, PhEtOH and  c HexEtOH; R 3  precursor includes acetyl chloride, t-butylacetyl chloride, cyclohexanecarbonyl chloride, 3,3-dimethylacryloyl chloride, benzoyl chloride, p-toluyl chloride, 4-anisoyl chloride, 4-fluorobenzoyl chloride, 2-thiopencarbonyl chloride and 2-furoyl chloride. 
     
       
         
           
               
               
             
               
                 TABLE 3 
               
               
                   
               
               
                 Compound No. 
                 NMR/MS Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.26˜6.56(m, 3H), 5.23(d, 1H, J=5.3Hz), 4.30(d, 1H, J=5.3Hz), 3.45(s, 3H), 2.82(s, 3H), 2.12(s, 3H), 1.35(s, 3H), 1.29(s, 3H); MS, m/z: 279.3 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.74˜6.55(m, 3H), 5.24(d, 1H, (J=6.0Hz), 4.35(d, 1H, J=6.0Hz), 3.41(s, 3H), 2.80(s, 3H), 2.27(s, 2H), 1.36(s, 3H), 1.29(s, 3H), 1.05(s, 9H); MS, m/z: 335.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.74(m, 3H), 5.23(d, 1H, J=5.8 Hz), 4.29(d, 1H, J=5.8Hz), 3.44(s, 3H), 2.81(s, 3H), 2.35(m, 1H), 1.93˜1.26(m, 10H), 1.34(s, 3H), 1.29(s, 3H); MS, m/z: 347.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.75˜6.58(m, 3H), 5.72(m, 1H), 5.26(d, 1H, J=5.3Hz), 4.31(d, 1H, J=5.3Hz), 3.48(s, 3H), 2.82(s, 3H), 2.18(s, 3H), 1.90(s, 3H), 1.36(s, 3H), 1.30(s, 3H); MS, m/z: 319.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.05(d, 1H, J=7.1Hz), 7.58-7.40(m, 3H), 6.79˜6.61(m, 3H), 5.48(d, 1H, J=5.5Hz), 4.46(d, 1H, J=5.5Hz), 3.52(s, 3H), 2.82(s, 3H), 1.41 (s, 3H), 1.39(s, 3H); MS, m/z: 341.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.07˜7.78(m, 2H), 7.27˜7.21(m, 2H), 6.87˜6.59(m, 3H), 5.46(d, 1H, J=5.6Hz), 4.44(d, 1H, J=5.6Hz), 3.52(s, 3H), 2.83(s, 3H), 2.41(s, 3H), 1.49-1.13(m, 6H); MS, m/z: 355.4 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 371.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z:359.4 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.83(m, 1H), 7.58(m, 1H), 7.14(m, 1H), 6.74(d, 1H, J=8.5Hz), 6.63˜6.51(m, 3H), 5.42(d, 1H, J=6.0Hz), 4.50(d, 1H, J=6.0Hz), 3.49(s, 3H), 2.81(s, 3H), 1.40(s, 3H), 1.36(s, 3H); MS, m/z: 347.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.60(m, 1H), 7.22(m, 1H), 6.74(d, 1H, J=8.3Hz), 6.62˜6.46(m, 3H), 5.43(d, 1H, J=5.8Hz), 4.47(d, 1H, J=5.8Hz), 3.48(s, 3H), 2.81(s, 3H), 1.40(s, 3H), 1.35(s, 3H); MS, m/z: 331.3 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.73˜6.53(m, 3H), 5.19(d, 1H, J=5.2Hz), 4.33(d, 1H, J=5.2Hz), 3.70(q, 2H, J=7.0Hz), 2.81 (s, 3H), 2.11 (s, 3H), 1.35(s, 3H), 1.29(s, 3H), 1.23(t, 3H, J=6.9Hz); MS, m/z: 293.3 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.73˜6.52(m, 3H), 5.21(d, 1H, J=5.7Hz), 4.38(d, 1H, J=5.7Hz), 3.66(q, 2H, J=6.9Hz), 2.80(s, 3H), 2.26(s, 3H), 1.36(s, 3H), 1.29(s, 3H), 1.21(t, 3H, J=6.9Hz), 1.04(s, 9H); MS, m/z: 349.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.73˜6.54(m, 3H), 5.19(d, 1H, J=5.6Hz), 4.33(d, 1H, J=5.6Hz), 3.67(q, 2H, J=6.9Hz), 2.80(s, 3H), 2.36(m, 1H), 1.90˜0.88(m, 10H), 1.34(s, 3H), 1.28(s, 3H), 1.22(t, 3H, J=6.9Hz); MS, m/z: 361.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.73˜6.54(m, 3H), 5.71(d, 1H, J=1.4Hz), 5.21(d, 1H, J=5.1Hz), 4.33(d, 1H, J=5.1Hz), 3.72(m, 2H), 2.80(s, 3H), 2.17(s, 3H), 1.89(s, 3H), 1.36(s, 3H), 1.30(s, 3H), 1.28˜1.26(m, 3H); MS, m/z: 333.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.07˜8.03(m, 2H), 7.90˜7.40(m, 3H), 6.85˜6.51(m, 3H), 5.44(d, 1H, J=5.2Hz), 4.59(d, 1H, J=5.2Hz), 3.77(m, 2H), 2.81 (s, 3H), 1.41 (s, 3H), 1.39(s, 3H), 1.23(t, 3H, J=6.9Hz); MS, m/z: 355.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.93(d, 2H, J=8.1Hz), 7.21(m, 2H), 6.84˜6.51(m, 3H), 5.42(d, 1H, J=5.1Hz), 4.48(d, 1H, J=5.1Hz), 3.77(m, 2H), 2.81(s, 3H), 2.40(s, 3H), 1.40(s, 3H), 1.38(s, 3H), 1.22(t, 3H, J=6.9Hz); MS, m/z: 369.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.99(d, 2H, J=9.1Hz), 6.90(d, 2H, J=9.1Hz), 6.74˜6.64(m, 3H), 5.40(d, 1H, J=5.0Hz), 4.42(d, 1H, J=5.0Hz), 3.85(s, 3H), 3.76(m, 2H), 2.82(s, 3H), 1.41(s, 3H), 1.38(s, 3H), 1.23(m, 3H); MS. m/z: 371.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.09˜8.02(m, 2H), 7.17˜7.06(m, 2H), 6.78˜6.62(m, 3H), 5.41(d, 1H, J=5.2Hz), 4.46(d, 1H, J=5.2Hz), 3.75(m, 2H), 2.82(s, 3H), 1.41 (s, 3H), 1.38(s, 3H), 1.23(m, 3H); MS, m/z: 373.4 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 361.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 345.4 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.90˜6.79(m, 3H), 5.04(d, 1H, J=4.0Hz), 4.24(d, 1H, J=4.0Hz), 4.06(m, 1H, 2.86(s, 3H), 2.08(s, 3H), 1.50˜1.20(m, 6H); MS, m/z: 307.3 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.75˜6.72(m, 3H), 5.02(d, 1H, J=3.6Hz), 4.21(d, 1H, J=3.6Hz), 4.10(m, 1H), 2.82(s, 3H), 2.22(s, 2H), 1.50˜1.12(m, 15H); MS, m/z: 363.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.81˜6.68(m, 3H), 5.04(d, 1H, J=3.9Hz), 4.20(d, 1H, J=3.9Hz), 4.06(m, 1H), 2.81(s, 3H), 2.32(m, 1H), 1.88˜1.19(m, 22H); MS, m/z: 375.5 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 347.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 369.4 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.97(d, 2H, J=9.0Hz), 6.92˜ 6.70(m, 5H), 5.27(d, 1H, J=4.1Hz), 4.38(1H, J=4.1Hz), 4.11(m, 1H), 4.38(s, 3H), 2.83(s, 3H), 1.42˜1.21(m, 12H); MS, m/z: 399.4 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 387.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 375.4 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.58(m, 1H), 7.17(m, 1H), 6.77˜ 6.62(m, 3H), 6.47(m, 1H), 5.24(d, 1H, J=4.4Hz), 4.39(d, 1H, J=4.4Hz), 4.10(m, 1H), 2.81(s, 3H), 1.41˜1.18(m, 12H); MS, m/z: 359.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.75˜6.59(m, 3H), 5.19(d, 1H, J=5.1Hz), 4.30(d, 1H, J=5.1Hz), 3.66(m, 2H), 2.81(s, 3H), 2.10(s, 3H), 1.59(m, 2H), 1.56(m, 2H), 1.35(s, 3H), 1.30(s, 3H), 0.92(t, 3H, J=7.2Hz): MS, m/z: 321.4 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 377.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 389.5 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.16˜6.77(m, 3H), 5.70(m, 1H), 5.21(d, 1H, J=4.7Hz), 4.28(d, 1H, J=4.7Hz), 3.70(m, 2H), 2.88(s, 3H), 2.17(s, 3H), 1.89(s, 3H), 1.58(m, 2H), 1.44(m, 2H), 1.37(s, 3H), 1.32(s, 3H), 0.91(t, 3H, J=7.2Hz); MS, m/z: 361.4 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 393.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 397.5 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.99(d, 2H, J=9.0Hz), 6.90(d, 2H, J=9.0Hz), 6.79˜6.63(m, 3H), 5.40(d, 1H, J=4.9Hz), 4.44(d, 1H, J=4.9Hz), 3.86(s, 3H), 3.68(m, 2H), 2.82(s, 3H), 1.70(m, 2H), 1.50(m, 2H), 1.41(s, 3H), 1.38(s, 3H), 0.95(m, 3H); MS, m/z: 399.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z; 401.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.82(m, 1H), 7.57(m, 1H), 7.11(m, 1H), 6.77˜6.59(m, 3H), 5.37(d, 1H, J=5.7Hz), 4.49(d, 1H, J=5.7Hz), 3.72(t, 2H, J=6.4Hz), 2.82(s, 3H), 1.58(m, 2H), 1.43(m, 2H), 1.41 (s, 3H), 1.37(s, 3H), 0.88(t, 3H, J=7.2Hz); MS, m/z: 389.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.60(m, 1H), 7.20(m, 1H), 6.74(d, 1H, J=8.5Hz), 6.64˜6.58(m, 2H), 6.50(m, 1H), 5.39(d, 1H, J=5.4Hz), 4.46(d, 1H, J=5.4Hz), 3.71(t, 2H, J=6.3Hz), 2.82(s, 3H), 1.66˜1.43(m, 4H), 1.40(s, 3H), 1.36(s, 3H), 0.89(t, 3H, J=7.2Hz); MS, m/z: 373.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.39˜7.26(m, 5H), 6.92˜6.76(m, 3H), 5.27(d, 1H, J=4.3Hz), 4.75(s, 2H), 4.40(d, 1H, J=4.4Hz), 2.81 (s, 3H), 2.09(s, 3H), 1.40(s, 3H), 1.35(s, 3H); MS, m/z: 355.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.38˜7.25(m, 5H), 7.10˜6.80(m, 3H), 5.28(d, 1H, J=4.0Hz), 4.75(s, 2H), 4.38(d, 1H, J=4.0 Hz), 2.84(s, 3H), 2.23(s, 2H), 1.44˜1.20(m, 6H), 1.00(s, 9H); MS, m/z: 411.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.40˜7.26(m, 5H), 6.78˜6.73(m, 3H), 5.29(d, 1H, J=4.6Hz), 4.72(s, 2H), 4.39(d, 1H, J=4.6 Hz), 2.79(s, 3H), 2.34(m, 1H), 1.89˜1.25(m, 11H), 1.38(s, 3H), 1.33(s, 3H); MS, m/z: 423.5 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 395.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 417.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 447.5 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.04(m, 2H), 7.41˜7.26(m, 5H), 7.10(m, 2H), 6.77˜6.56(m, 3H), 5.49(d, 1H, J=4.4Hz), 4.80(s, 2H), 4.56(d, 1H, J=4.4Hz), 2.77(s, 3H), 1.45(s, 3H), 1.41(s, 3H); MS, m/z: 435.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.83(m, 1H), 7.58(m, 1H), 7.36(m, 5H), 7.27(m, 1H), 6.77˜6.25(m, 3H), 5.46(d, 1H, J=4.4Hz), 4.79(s, 2H), 4.61 (d, 1H, J=4.4Hz), 2.78(s, 3H), 1.44(s, 3H), 1.40(s, 3H); MS, m/z: 423.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.60(m, 1H), 7.42˜7.26(m, 5H), 7.18(d, 1H, J=3.5Hz), 6.79˜6.63(m, 3H), 6.51˜6.48(m, 1H), 5.47(d, 1H, J=5.0Hz), 4.78(s, 2H), 4.58(d, 1H, J=4.0Hz), 2.76(s, 3H), 1.44(s, 3H), 1.39(s, 3H); MS, m/z: 407.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.30˜7.20(m, 5H), 6.70(d, 1H, J=8.7Hz), 6.56(dd, 1H, J=8.7Hz, J=2.6Hz), 6.39(d, 1H, J=6.7Hz), 2.91 (t, 2H, J=6.7Hz), 2.76(s, 3H), 2.08(s, 3H), 1.27(s, 6H); MS, m/z: 369.4 J = 2.6 Hz), 5.16(d, 1H, J = 5.3 Hz), 4.32(d, 1H, J = 5.3 Hz), 3.89(t, 2H, 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.89˜7.20(m, 5H), 6.72˜6.07(m, 3H), 5.17(d, 1H, J=5.5Hz), 4.36(d, 1H, J=5.5Hz), 3.85(t, 2H, J=6.7Hz), 2.89(t, 2H, J=6.7Hz), 2.75(s, 3H), 2.17(s, 2H), 1.29(s, 3H), 1.27(s, 3H), 1.04(s, 9H); MS, m/z: 425.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.29˜7.19(m, 5H), 6.71˜6.37(m, 3H), 5.17(d, 1H, J=5.5Hz), 4.32(d, 1H, J=5.5Hz), 3.86(t, 2H, J=6.7Hz), 2.89(t, 2H, J=6.7Hz), 2.75(s, 3H), 2.33(m, 1H), 1.90˜1.26(m, 17H); MS, m/z: 437.5 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 409.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.5 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.01˜7.96(m, 2H), 7.27˜7.20(m, 5H), 6.93˜6.51 (m, 5H), 5.37(d, 1H, J=5.0Hz), 4.43(d, 1H, J=5.0Hz), 3.96(m, 2H), 3.86(s, 3H), 2.90(m, 2H), 2.77(s, 3H), 1.37˜1.30(m, 6H); MS, m/z: 461.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.15˜8.01(m, 2H), 7.28˜7.24(m, 5H), 7.24˜7.02(m, 2H), 6.79˜6.24(m, 3H), 5.37(d, 1H, J=5.1 HZ), 4.45(d, 1H, J=5.1Hz), 3.95(t, 2H, J=6.8Hz), 2.90(t, 2H, J=6.8Hz), 2.75(s, 3H), 1.34(s, 3H), 1.31(s, 3H); MS, m/z: 437.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.82(m, 1H). 7.57(m, 1H), 7.27˜ 7.15(m, 5H), 7.09(m, 1H), 6.78˜6.34(m, 3H), 5.35(d, 1H, J=5.9Hz), 4.50(d, 1H, J=5.9Hz), 3.94(t, 2H, J=6.7Hz), 2.90(t, 2H, J=6.7Hz), 2.74(s, 3H), 1.33(s, 6H); MS, m/z: 437.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.60(m, 1H), 7.26˜7.18(m, 6H), 6.73˜6.27(m, 4H), 5.36(d, 1H, J=5.7Hz), 4.48(d, 1H, J=5.7 Hz), 3.93(t, 2H, J=6.8Hz), 2.90(t, 2H, J=6.8Hz), 2.74(s, 3H), s, 6H); MS, m/z: 421 .5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.19˜6.75(m, 3H), 5.14(d, 1H, J=4.5Hz), 4.23(d, 1H, J=4.5Hz), 3.71(m, 2H), 2.86(s, 3H), 2.07(s, 3H), 1.64˜0.86(m, 13H), 1.33(s, 3H), 1.29(s, 3H); MS, m/z 375.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.07˜6.56(m, 3H), 5.15(d, 1H, J=4.9Hz), 4.22(d, 1H, J=4.9Hz), 3.69(m, 2H), 2.86(s, 3H), 2.30(m, 1H), 1.87˜0.86(m, 13H), 1.32(s, 3H), 1.28(s, 3H); MS, m/z: 443.6 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 415.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z 437.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z 467.6 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.01(m, 2H), 7.27˜6.84(m, 5H), 5.73(d, 1H, J=4.1Hz), 4.38(d, 1H, J=4.1Hz), 3.75(m, 2H), 2.89(s, 3H), 1.79˜1.12(m, 19H); MS, m/z: 455.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 443.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.56(m, 1H), 7.13(m, 1H), 6.70(d, 1H, J=8.1Hz), 6.57˜6.46(m, 3H), 5.36(d, 1H, J=5.5Hz), 4.43(d, 1H, J=5.5Hz), 3.68(m, 2H), 2.78(s, 3H), 1.62˜ 0.86(m, 13H), 1.37(s, 3H), 1.33(s, 3H); MS, m/z: 427.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.72˜6.54(m, 3H), 5.22(d, 1H, J=5.5Hz), 4.30(d, 1H, J=5.5Hz), 3.43(s, 3H), 3.10(q, 2H, J=7.1Hz), 2.11(s, 3H), 1.34(s, 3H), 1.28(s, 3H), 1.20(m, 3H); MS, m/z: 293.3 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.76˜6.69(m, 3H), 5.24(d, 1H, J=5.7Hz), 4.33(d, 1H, J=5.9Hz), 3.41(s, 3H), 3.14(q, 2H, J=7.1Hz), 2.26(s, 2H), 1.36(s, 3H), 1.29(s, 3H), 1.24(m, 3H), 1.04(s, 9H); MS, m/z: 349.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.74˜6.61(m, 3H), 5.22(d, 1H, J=5.6Hz), 4.28(d, 1H, J=5.6Hz), 3.43(s, 3H), 3.13(q, 2H, J=7.1Hz), 2.36(m, 1H), 2.00˜1.21(br, 10Hz), 1.33(s, 3H), 1.28(s, 3H), 1.24(m, 3H); MS, m/z: 361.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.97˜6.74(m, 3H), 5.71(d, 1H, J=1.5Hz), 5.24(d, 1H, J=5.0Hz), 4.26(d, 1H, J=5.0Hz), 3.49(s, 3H), 3.18(q, 2H, J=7.1Hz), 2.18(s, 3H), 1.89(s, 3H), 1.35(s, 3H), 1.31(s, 3H), 1.25(m, 3H); MS, m/z: 333.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.08˜8.03(m, 2H), 7.58˜7.53(m, 1H), 7.48˜7.26(m, 2H), 6.82˜6.75(m, 3H0, 5.47(d, 1H, J=5.5 Hz), 4.44(d, 1H, J=5.5Hz), 3.51(s, 3H), 3.15(q, 2H, J=7.2Hz), 1.41 (s, 3H), 1.39(s, 3H), 1.25(t, 3H, J=7.2Hz); MS, m/z: 355.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.03(d, 2H, J=7.6Hz), 7.23(d, 2H, J=7.6Hz), 6.82˜6.75(m, 3H), 5.46(d, 1H, J=5.5Hz), 4.43(d, 1H, J=5.5Hz), 3.51(s, 3H), 3.15(q, 2H, J=7.2Hz), 2.41(s, 3H), 40(s, 3H), 1.38(s, 3H), 1.25(t, 3H, J=7.1Hz); MS, m/z: 369.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.10˜8.03(m, 2H), 7.25˜7.06(m, 2H), 6.78˜6.64(m, 3H), 5.45(d, 1H, J=5.4Hz), 4.43(d, 1H, J=5.4Hz), 3.50(s, 3H), 3.13(q, 2H, J=7.1Hz), 1.40(s, 3H), 1.37(s, 3H), 1.24(t, 3H, J=7.1Hz); MS, m/z: 373.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.85˜7.82(m, 1H), 7.60˜7.57(m, 1H), 7.13˜7.09(m, 1H), 6.73(d, 1H, J=10.5 6.54(m, 2H), 5.42(d, 1H, J=6.2Hz), 4.50(d, 1H, J=6.2Hz), 3.47(s, 3H), 3.12(q, 2H, J=7.1Hz), 1.40(s, 3H), 1.36(s, 3H), 1.24(t, 3H, J=7.0Hz), ; MS, m/z: 361.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.60˜7.56(m, 1H), 7.26˜7.17(m, 1H), 6.75˜6.47(m, 4H), 5.43(d, 1H, J=5.9Hz), 4.47(d, 1H, J=5.9Hz), 3.46(s, 3H), 3.07(q, 2H, J=7.2Hz), 1 .39(s, 3H), 1.35(s, 3H). 1.23(t, 3H, J=7.1Hz); MS, m/z: 345.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 307.3 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.72˜6.62(m, 3H), 5.21(d, 1H, J=5.7Hz), 4.37(d, 1H, J=5.7Hz), 3.65(q, 2H, J=7.1Hz), 3.12(q, 2H, J=7.1Hz), 2.26(s, 2H), 1.36(s, 3H), 1.29(s, 3H), 1.21(m, 3H), 1.04(s, 9H); MS, m/z: 307.3 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.69(d, 1H, J=8.5Hz), 6.62˜ 6.55(m, 2H), 5.19(d, 1H, J=5.7Hz), 4.32(d, 1H, J=5.7Hz), 3.65(q, 2H, J=7.1Hz), 3.10(q, 2H, J=7.1Hz), 2.35(m, 1H), 1.74˜1.17(m, 16H), 1.33(s, 3H), 1.28(s, 3H); MS, m/z: 375.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z 347,4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.07˜8.03(m, 2H), 7.57˜7.39(m, 3H), 6.78˜6.61(m, 3H), 5.449d, 1H, J=5.4Hz), 4.48(d, 1H, J=5.4Hz), 3.76(q, 2H, J=7.1Hz), 3.13(q, 2H, J=7.1Hz), 1.41(s, 3H), 1.39(s, 3H), 1.28˜1.19(m, 6H); MS, m/z: 369.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.93(d, 1H, J=8.1Hz), 7.23(d, 1H, J=8.0Hz), 6.78˜6.68(m, 3H), 5.42(d, 1H, J=5.4Hz), 4.47(d, 1H, J=5.4Hz), 3.76(q, 2H, J=6.9Hz), 3.12(q, 2H, J=7.1Hz), 2.40(s, 3H), 1.40(s, 3H), 1.38(s, 3H), 1.29˜1.18(m, 6H); MS, m/z: 383.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.00(d, 2H, J=9.0Hz), 6.90(d, 2H, J=9.0Hz), 6.76˜6.71 (m, 3H), 5.41(d, 1H, J=5.4Hz), 4.46(d, 1H, J=5.4Hz), 3.85(s, 3H), 3.76(q, 2H, J=6.9Hz), 3.14(q, 2H, J=7.1Hz) 1.40(s, 3H), 1.38(s, 3H), 1.29˜1.18(m, 6H); MS, m/z: 399.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.09˜8.02(m, 2H), 7.15˜7.069 m, 2H), 6.74(d, 1H, J=8.5Hz), 6.64˜6.58(m, 2H), 5.42(d, 1H, J=5.3Hz), 4.46(d, 1H, J=5.3Hz), 3.71(q, 2H, J=7.1Hz), 3.12(q, 2H, J=7.1Hz), 1.41(s, 3H), 1.37(s, 3H), 1.28˜1.19(m, 6H); MS, m/z: 387.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.84˜7.81(m, 1H), 7.60˜7.56(m, 1H), 7.13˜7.08(m, 1H), 6.75˜6.57(m, 3H), 5.37(d, 1H, J=5.9 Hz), 4.51(d, 1H, J=5.9Hz), 3.74(q, 2H, J=6.9Hz), 3.12(q, 2H, J=7.1Hz), 1.40(s, 3H), 1.36(s, 3H), 1.28˜1.15(m, 6H); MS, m/z: 375.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.60(m, 1H0, 7.20˜7.18(m, 1H), 6.72(d, 1H, J=8.5Hz), 6.66˜6.49(m, 2H), 5.39(d, 1H, J=5.7 Hz), 4.49(d, 1H, J=5.7Hz), 3.72(q, 2H, J=6.9Hz), 3.12(q, 2H, J=7.1Hz), 1.40(s, 3H), 1.35(s, 3H), 1.28˜1.18(m, 6H); MS, m/z: 359.4 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 321.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 377.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 389.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 361.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 397.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 413.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 401.3 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 389.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 373.4 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.69(d, 1H, J=8.3Hz), 6.57˜ 6.52(m, 2H), 5.19(d, 1H, J=5.1Hz), 4.30(d, 1H, J=5.1Hz), 3.64(m, 2H), 3.11(q, 2H, J=7.1Hz), 2.10(s, 3H), 1.55(m, 2H), 1.42(m, 2H), 1.35(s, 3H), 1.29(s, 3H); MS, m/z: 335.4 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 391.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 403.5 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 6.72˜6.52(m, 3H), 5.71(d, 1H, J=1.2Hz), 5.21(d, 1H, J=5.2Hz), 3.68(m, 2H), 2.17(s, 3H), 1.89(s, 3H), 1.54(m, 2H), 1.42(m, 2H), 1.35(s, 3H), 1.30(s, 3H), 1.24(t, 3H, J=7.1Hz), 0.91(t, 3H, J=7.2Hz); MS, m/z: 375.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.07˜8.02(m, 2H), 7.57˜7.26(m, 3H), 6.77˜6.59(m, 3H), 5.43(d, 1H, J=5.3Hz), 4.45(d, 1H, J=5.3Hz), 3.72(m, 2H), 3.10(m, 2H), 1.54(m, 2H), 1.45(m, 2H), 1.41 (s, 3H), 1.39(s, 3H), 1.24(m, 3H), 0.88(t, 3H, J=7.2 Hz); MS, m/z: 397.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.93(d, 2H, J=8.6Hz), 7.25˜ 7.20(m, 2H), 6.74(d, 1H, J=8.5Hz), 6.65˜6.63(m, 2H), 5.42(d, 1H, J=5.3Hz), 4.44(d, 1H, J=5.3Hz), 3.72(q, 2H, J=7.1Hz), 2.40(s, 3H), 1.55(m, 2H), 1.43˜1.28(m, 2H), 1.40(s, 3H), 1.37(s, 3H), 1.24(t, 3H, J=7.1Hz), 0.88(t, 3H, J=7.2Hz); MS, m/z: 411.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.99(d, 2H, J=8.2Hz), 6.90(d, 2H, J=8.2Hz), 5.40(d, 1H, J=4.5Hz), 4.42(d, 1H, J=4.5Hz), 3.85(s, 3H-), 3.71(m, 2H), 3.11(m, 2H), 1.57˜1.35(m, 4H), 1.40(s, 3H), 1.37(s, 3H), 1.24(m, 3H), 0.88(t, 3H, J=7.1Hz); MS, m/z: 413.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 415.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.84˜7.81(m, 1H), 7.59˜7.56(m, 1H), 7.13˜7.08(m, 1H), 6.72(d, 1H, J=8.5Hz), 6.64˜6.54(m, 2H), 5.37(d, 1H, J=6.0Hz), 4.48(d, 1H, J=6.0Hz), 3.70(t, 2H, J=6.4Hz), 3.11(q, 2H, J=7.1Hz), 1.61˜1.46(m, 2H), 1.43˜ 1.32(m, 2H), 1.40(s, 3H), 1.36(s, 3H), 1.24(t, 3H, J=7.1Hz), 0.88(t, 3H, J=7.1Hz); MS, m/z: 403.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.59(m, 1H), 7.20˜7.18(m, 2H), 6.72(d, 1H, J=8.5Hz), 6.62˜6.49(m, 3H), 5.39(d, 1H, J=5.6 Hz), 4.45(d, 1H, J=5.6Hz), 3.69(t, 2H, J=6.9Hz), 3.10(q, 2H, J=7.2Hz), 1.55(m,.2H), 1.51˜1.35(m, 2H), 1.39(s, 3H), 1.35(s, 3H), 1.24(t, 3H, J=7.1Hz), 0.88(t, 3H, J=7.2Hz); MS, m/z: 387.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.42˜7.24(m, 5H), 6.73˜6.47(m, 3H), 5.27(d, 1H, J=4.7Hz), 4.72(s, 2H), 4.42(d, 1H, J=4.7 Hz), 3.05(q, 2H, J=7.1Hz), 2.10(s, 3H), 1.39(s, 3H), 1.33(s, 3H), 1.22(t, 3H, J=7.1Hz); MS, m/z: 369.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.42˜7.28(m, 5H), 6.70(d, 1H, J=8.5Hz), 6.57˜6.43(m, 2H), 5.29(d, 1H, J=5.0Hz), 4.70(s, 2H), 4.44(d, 1H, J=5.0Hz), 3.04(q, 2H, J=7.1Hz), 2.25(s, 2H), 1.40(s, 3H), 1.33(s, 3H), 1.21(t ,3H, J=7.1Hz), 1.02(s, 9H); MS, m/z: 425.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.41˜7.26(m, 5H), 6.70(d, 1H, J=8.5Hz), 6.57˜6.47(m, 2H), 5.29(d, 1H, J=5.1Hz), 4.70(s, 2H), 4.41(d, 1H, J=5.1Hz), 3.05(q, 2H, J=7.1Hz), 2.35(m, 1H), 2.00˜1.18(m, 10H), 1.38(s, 3H), 1.32(s, 3H), 1.21(m, 3H); MS, m/z: 437.5 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 409.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.5 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/zL 445.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.01(d, 2H, J=8.9Hz), 7.40˜ 7.27(m,SH), 6.90(d, 2H, J=8.9Hz), 6.75(d, 1H, J=8.6Hz), 6.64˜6.28(m, 2H), 5.49(d, 1H, J=4.9Hz), 4.79(s, 2H), 4.56(d, 1H, J=4.9Hz), 3.85(s, 3H), 3.05(q, 2H, J=7.0Hz), 1.44(s, 3H), 1.40(s, 3H), 1.21(m, 3H); MS, m/z: 461.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.84˜7.82(m, 1H), 7.60(m, 1H), 7.40˜7.26(m, 5H), 6.73(d ,1H, J=8.3Hz), 6.59˜6.51(m, 2H), 5.47(d, 1H, J=5.3Hz), 4.77(s, 2H), 4.62(d, 1H, J=5.3Hz), 3.03(q, 2H, J=7.1Hz), 1.44(s, 3H), 1.39(s, 3H), 1.21(t, 3H, J=7.1Hz); MS, m/z: 437.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.60˜7.59(m, 1H), 7.41˜7.18(m, 6H), 6.73(d, 1H, J=8.5Hz), 6.59˜6.45(m, 3H), 5.47(d, 1H, J=5.1Hz), 4.77(s, 2H), 4.58(d, 1H, J=5.0Hz), 3.10˜3.02(m, 2H), 1.43(s, 3H), 1.39(s, 3H), 1.21(m, 3H); MS, m/z: 421.5 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 439.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 423.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 475.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 389.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 457.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 429.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 465.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 481.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 469.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 457.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 441.5 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.25˜7.37(m, 5H), 6.59˜ 6.70(m, 3H), 5.18(d, 1H, J=5.09Hz), 4.28(d, 1H, J=5.09 Hz), 4.27(s, 2H), 3.56˜3.60(m, 2H), 2.10(s, 3H), 2.03˜ 2.09(m, 1H), 1.38˜1.50(m, 2H), 1.35(s, 3H), 1.29(s, 3H), 1.26˜1.35(m, 2H), 0.91(t, 3H, J=7.12Hz) MS, m/z: 355.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 411.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.23˜7.40(m, 5H), 6.54˜ 6.71(m, 3H), 5.18(d, 1H, J=5.49Hz), 4.28(d, 1H, J=5.49 Hz), 4.27(s, 2H), 3.52˜3.61(m, 2H), 2.29˜2.34(m, 1H), 1.30˜1.89(m, 14H), 1.33(s, 3H), 1.27(s, 3H), 0.90(t, 3H, J=7.12Hz); MS, m/z: 423.5 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 395.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 417.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 447.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 423.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 407.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 369.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 425.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 437.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 409.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 461.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 437.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 421.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 439.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 423.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 495.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 475.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 397.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 453.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 465.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 427.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 489.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 465.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 431.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 487.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 499.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 471.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 493.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 507.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 523.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 499.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 483.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 501.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 513.68 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 485.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 507.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 521.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 537.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 525.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 513.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 497.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 507.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 519.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 491.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 513.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 527.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 543.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 531.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 519.7 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 503.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.28(d, 2H, J=8.5Hz), 6.86(d, 2H, J=8.5Hz), 6.72˜6.55(m, 3H), 5.22(d, 1H, J=5.7Hz), 4.29(d, 1H, J=5.7Hz), 4.19(s, 2H), 3.79(s, 3H), 3.40(s, 3H), 2.11(s, 3H), 1.34(s, 3H), 1.28(s, 3H); MS, m/z: 385.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.27(m, 2H), 6.87(d, 2H, J=8.7Hz), 6.70(d, 1H, J=8.5Hz), 6.62˜6.50(m, 2H), 5.24(d, 1H, J=6.0Hz), 4.34(d, 1H, J=6.0Hz), 4.20(s, 2H), 3.80(s, 3H), 3.37(s, 3H), 2.27(s, 3H), 1.36(s, 3H), 1.29(s, 3H), 1.05(s, 9H); MS, m/z: 441.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.28(d, 2H, J=9.0Hz), 6.86(d, 2H, J=9.0Hz), 6.84˜6.60(m, 3H), 5.22(d, 1H, J=5.7Hz), 4.30(d, 1H, J=5.7Hz), 4.19(s, 3H), 3.79(s, 3H), 3.38(s, 1.28(s, 3H); MS, m/z: 453.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.28(d, 2H, J=9.0Hz), 6.86(d, 2H, J=9.0Hz), 6.72˜6.56(m, 3H), 5.71 (d, 1H, J=1.2Hz), 5.25(d, 1H, J=5.3Hz), 4.29(d, 1H, J=5.3Hz), 4.19(s, 2H), 3.79(s, 3H), 3.44(s, 3H), 2.18(s, 3H), 1.89(s, 3H), 1.35(s, 3H), 1.29(s, 3H); MS, m/z: 425.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.05(d, 2H, J=8.3Hz), 7.61˜ 7.19(m, 5H), 6.89˜6.57(m, 5H), 5.48(d, 1H, J=5.7Hz), 4.45(d, H, J=5.7Hz), 4.20(s, 2H), 3.79(s, 3H), 3.47(s, 3H), 1.41(s, 3H), 1.38(s, 3H); MS, m/z: 447.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.94(d, 2H, J=8.3Hz), 7.31˜ 7.21(m, 4H), 6.89˜6.62(m, 5H), 5.46(d, 1H, J=5.6Hz), 4.44(d, 1H, J=5.6Hz), 4.20(s, 2H), 3.80(s, 3H), 3.47(s, 3H), 2.41(s, 3H), 1.40(s, 3H), 1.38(s, 3H); MS, m/z: 461.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.99(d, 2H, J=9.0Hz), 6.94˜ 6.64(m, 5H), 5.43(d, 1H, J=5.5Hz), 4.41 (d, 1H, J=5.5Hz), 4.19(s, 2H), 3.86(s, 3H), 3.78(s, 3H), 3.47(s, 3H), 1.39(s, 3H), 1.37(s, 3H); MS, m/z: 477.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.10˜8.03(m, 2H), 7.31 7.25(m, 2H), 7.15˜7.07(m, 2H), 6.87(d, 2H, J=8.8Hz), 6.75(d, 1H, 8.5Hz), 5.45(d, 1H, J=5.4Hz), 4.44(d, 1H, J=5.4Hz), 4.20(s, 2H), 3.80(s, 3H), 3.46(s, 3H), 1.41(s, 3H), 1.38(s, 3H); MS, m/z: 465.5 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 453.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 437.5 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.31˜7.25(m, 2H), 6.91˜ 6.85(m, 2H), 6.72˜6.59(m, 3H), 5.18(d, 1H, J=5.4Hz), 4.31(d, 1H, J=5.4Hz), 4.20(s, 2H), 3.80(s, 3H), 3.70˜ 3.59(m, 2H), 2.10(s, 3H), 1.35(s, 3H), 1.29(s, 3H), 1.18(t, 3H, J=7.1Hz); MS, m/z: 399.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.28(d, 2H, J=8.6Hz), 6.87(d, 2H, J 32  8.6Hz), 6.72˜6.58(m, 3H), 5.20(d, 1H, J=5.8Hz), 4.36(d, 1H, J=5.8Hz), 4.20(s, 2H), 3.80(s, 3H), 3.60(q, 2H, J=6.9Hz), 2.26(s, 2H), 1.36(s, 3H), 1.29(s, 3H), 1.17(t, 3H, J=6.9Hz), 1.04(s, 9H); MS, m/z: 455.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.29(d, 2H, J=8.4Hz), 6.87(d, 2H, J=8.5Hz), 6.72˜6.55(m, 3H), 5.19(d, 1H, J=5.7Hz), 4.32(d, 1H, J=5.7Hz), 4.20(s, 2H), 3.80(s, 3H), 3.62(q, 2H, J=6.9Hz), 2.35(m, 1H), 1.90˜1.22(m, 13H), 1.34(s, 3H), 1.28(s, 3H), 1.17(t, 3H, J=6.9Hz); MS, m/z: 467.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.29(d, 2H, J=8.5Hz), 6.87(d, 2H, J=8.5Hz), 6.72˜6.54(m, 3H), 5.72(d, 1H, J=1.2Hz), 5.21(d, 1H, J=5.2Hz), 4.32(d, 1H, J=5.2Hz), 4.19(s, 2H), 3.80(s, 3H), 3.67(m, 2H), 2.17(s, 3H), 1.89(s, 3H), 1.36(s, 3H), 1.30(s, 3H), 1.18(m, 3H): MS, m/z: 439.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.08˜8.03(m, 2H), 7.58˜ 7.26(m, 5H), 6.87(d, 2H, J=8.5Hz), 6.74(d, 2H, J=8.5Hz), 6.64˜6.57(m, 3H), 5.43(d, 1H, J=5.4Hz), 4.47(d, 1H, J=5.4Hz), 4.20(s, 2H), 3.80(s, 3H), 3.77˜3.67(m, 2H), 1.41(s, 3H), 1.38(s, 3H), 1.18(t, 3H, J=6.9Hz); MS, m/z:461.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 475.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.99(d, 2H, J=9.0Hz), 7.29(d, 2H, J=9.0Hz), 6.93˜6.80(m, 4H), 6.77˜6.49(m, 3H), 5.49(d, 1H, J=5.2Hz), 4.45(d, 1H, J=5.2Hz), 4.20(s, 2H), 3.85(s, 3H), 3.79(s, 3H), 3.76(m, 2H), 1.40(s, 3H), 1.37(s, 3H), 1.18(t, 3H, J=7.0Hz); MS, m/z: 491.5 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 479.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 467.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 413.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 469.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 481.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 453.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 475.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 489.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 505.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 493.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 481.6 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 465.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.39(d, 2H, J=8.7Hz), 6.88(d, 2H, J=8.7Hz0, 6.83˜6.55(m, 3H), 5.18(d, 1H, J=5.2Hz), 4.28(d, 1H, J=5.2Hz), 4.19(s, 2H), 3.80(s, 3H), 3.75˜ 1.38(m, 2H), 1.35(s, 3H), 1.29(s, 3H), 0.91 (t, 3H); MS, m/z: 427.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.28(d, 2H, J=9.0Hz), 6.86(d, 2H, J=8.6Hz), 6.72˜6.60(m, 3H), 5.19(d, 1H, J=5.4Hz), 2H, J=6.3Hz), 2.25(s, 3H), 1.53˜1.42(m, 4H), 1.36(s, 3H), 1.29(s, 3H), 1.04(s, 9H), 0.93(m, 3H); MS, m/z: 483.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.29(d, 2H, J=8.7Hz), 6.87(d, 2H, J=8.7Hz), 6.72˜6.60(m, 3H), 5.18(d, 1H, J=5.5Hz), 4.28(d, 1H, J=5.5Hz), 4.19(s, 2H), 3.79(s, 3H), 3.58˜ 3.57(m, 2H), 2.30(m, 1H), 2.0˜1.20(m, 14H), 1.33(s, 3H), 1.28(s, 3H), 0.90(t, 3H, J=7.2Hz); MS, m/z: 495.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.28(d, 2H, J=8.7Hz), 6.86(d, 2H, J=8.7Hz), 6.72˜6.60(m, 3H), 5.70(d, 1H, J=1.2Hz), 5.20(d, 1H, J=5.0Hz), 4.28(d, 1H, J=5.0Hz), 4.19(s, 2H), 3.79(s, 3H), 3.68˜3.55(m, 2H), 2.17(s, 3H), 1.89(s, 3H), 1.62˜1.45(m, 2H), 1.42˜1.26(m, 2H), 1.35(s, 3H), 1.29(s, 3H), 0.90(t, 3H, J=7.2Hz); MS, m/z: 467.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.04(d, 2H, J=8.7Hz), 7.57˜ 7.25(m, 6H), 6.88˜6.61(m, 5H), 5.43(d, 1H, J=5.2Hz), 4.43(d, 1H, J=5.2Hz), 4.20(s, 2H), 3.79(s, 3H), 3.72˜ 3.65(m, 2H), 1.54˜1.26(m, 4H), 1.41(s, 3H), 1.39(s, 3H), 0.87(t, 3H, J=7.2Hz); MS, m/z: 489.6 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 503.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 519.6 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.08˜8.01 (m, 2H), 7.30˜ 7.14(m, 2H), 7.10˜7.05(m, 2H), 6.87˜6.73(m, 5H), 5.39(d, 1H, J=5.1Hz), 4.40(d, 1H, J=5.1Hz), 4.19(s, 2H), 3.78(s, 3H), 3.66(m, 2H), 1.57˜1.25(m, 4H), 1.40(s, 3H), 1.37(s, 3H), 0.87(t, 3H, J=7.2Hz); MS, m/z: 507.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.38˜7.23(m, 7H), 6.88˜ 6.53(m, 5H), 5.28(d, 1H, J=4.7Hz), 4.69(s, 2H), 4.41(d, 1H, J=4.7Hz), 4.13(s, 2H), 3.79(s, 3H), 2.10(s, 3H), 1.39(s, 3H), 1.33(s, 3H); MS, m/z: 461.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.38˜7.23(m, 7H), 6.85(d, 2H, J=8.5Hz), 6.79˜6.56(m, 3H), 5.29(d, 1H, J=4.9Hz), 4.67(s, 2H), 4.41(d, 1H, J=4.9Hz), 4.12(s, 2H), 3.78(s, 3H), 2.25(s, 2H), 1.40(s, 3H), 1.33(s, 3H), 1.02(s, 9H); MS, m/z: 517.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.38˜7.18(m, 7H), 6.85(d, 2H, J=8.5Hz), 6.79˜6.58(m, 3H), 5.29(d, 1H, J=4.9Hz), 4.66(s, 2H), 4.40(d, 1H, J=4.9Hz), 4.13(s, 2H), 3.78(s, 3H), 2.34(m, 1H), 2.00˜1.20(m, 10H), 1.37(s, 3H), 1.32(s, 3H); MS, m/z: 529.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.38˜7.18(m, 7H), 6.88˜ 6.52(m, 5H), 5.71(d, 1H, J=1.4Hz), 5.32(d, 1H, J=4.6Hz), 4.72(s, 2H), 4.42(d, 1H, J=4.6Hz), 4.12(s, 2H), 3.17(s, 3H), 2.19(s, 3H), 1.89(s, 3H), 1.40(s, 3H), 1.33(s, 3H); MS, m/z: 501.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.08˜7.98(m, 2H), 7.58˜ 7.19(m, 10H), 6.87˜6.58(m, 5H), 5.52(d, 1H, J=4.7Hz), 4.76(s, 2H), 4.57(d, 1H, J=4.7Hz), 4.13(s, 2H), 3.77(s, 3H), 1.45(3, 3H), 1.42(3, 3H); MS, m/z: 523.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.94(d, 2H, J=8.3Hz), 7.33˜ 7.19(m, 9H), 6.89˜6.73(m, 3H), 6.61˜6.52(m, 2H), 5.52(d, 1H, J=4.8Hz), 4.75(s, 2H), 4.47(d, 1H, J=4.8Hz), 4.13(s, 2H), 3.79(s, 3H), 2.41(s, 3H), 1.44(s, 3H), 1.41(s, 3H); MS, m/z: 537.6 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 553.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 541.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 529.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 513.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 475.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 531.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 543.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 515.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 537.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 551.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 567.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 555.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 543.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 527.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 481.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 537.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 549.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 521.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 543.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 557.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 573.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 561.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 549.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 533.6 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.26˜7.37(m, 2H), 6.97˜ 7.06(m, 2H), 6.53˜6.68(m, 3H), 5.22(d, 1H, J=5.70Hz), 4.28(d, 1H, J=5.70Hz), 4.24(s, 2H), 3.40(s, 3H), 2.11(s, 3H), 1.34(s, 3h), 1.26(s, 3H); MS, m/z: 373.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.26˜7.36(m, 2H), 6.97˜ 7.05(m, 2H), 6.55˜6.72(m, 3H), 5.23(d, 1H, J=6.10Hz), 5.32(d, 1H, J=6.10), 4.24(s, 2H), 3.35(3, 3H), 2.26(s, 2H), 1.36(s, 3H), 1.28(s, 3H), 1.04(s, 9H); MS, m/z: 429.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.26˜7.37(m, 2H), 6.97˜ 7.06(m, 2H), 6.53˜6.72(m, 5.21(d, 1H J=5.90Hz), 4.27(d, 1H, J=5.90Hz), 4.24(s, 2H), 3.37(s, 3H), 2.31˜ 2.41(m, 1H), 1.37˜1.92(m, 10H), 1.33(s, 3H), 1.28(s, 3H); MS, m/z: 441.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 413.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.30˜7.58(m, 7H), 6.97˜ 7.05(m, 2H), 6.58˜6.77(m, 3H), 5.46(d, 1H, J=5.49Hz), 4.44(d, 1H, J=5.49), 4.25(s, 2H), 3.46(s, 3H), 1.40(s, 3H), 1.38(s, 3H) MS, m/z: 435.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.93(d, 2H, J=8.34Hz), 7.21˜ 7.37(m, 4H), 6.96˜7.05(m, 2H), 6.59˜6.77(m, 3H), 5.44(d, 1H, J=5.49Hz), 4.42(d, 1H, J=5.49Hz), 4.25(s, 2H), 3.45(s, 3H), 2.41(s, 3H), 1.39(s, 3H), 1.37(s, 3H); MS, m/z: 449.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.98˜8.02(m, 2H), 7.30˜ 7.37(m, 2H), 6.88˜7.05(m, 4H), 6.59˜6.77(m, 3H), 5.44(d, 1H, J=5.49Hz), 4.41(d, 1H, J=5.49Hz), 4.25(s, 2H), 3.86(s, 3H), 3.46(s, 3H), 1.39(s, 3H), 1.37(s, 3H); MS, m/z: 465.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.03˜8.10(m, 2H), 7.26˜ 7.37(m, 2H), 6.97˜7.25(m, 4H), 6.58˜6.77(m, 3H), 5.45(d, 1H, J=5.49Hz), 4.42(d, 1H, J=5.49Hz), 4.25(s, 2H), 3.45(s, 3H), 1.40(s, 3H), 1.37(s, 3H); MS, m/z: 453.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.82˜7.85(m, 1H), 7.57˜ 7.60(m, 1H), 7.26˜7.37(m, 2H), 6.97˜7.13(m, 3H), 6.55˜ 6.75(m, 3H), 5.40(d, 1H, J=6.10Hz), 4.48(d, 1H, J=6.30 Hz), 4.25(s, 2H), 3.44(s, 3H), 1.40(s, 3H), 1.36(s, 3H); MS, m/z: 441.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.59˜7.60(m, 1H), 7.19˜ 7.37(m, 3H), 6.97˜7.05(m, 2H), 6.49˜6.75(m, 4H), 5.42(d, 1H, J=5.90Hz), 4.45(d, 1H, J=5.90Hz), 4.24(s, 2H), 3.42(s, 3H), 1.39(s, 3H), 1.35(s, 3H) MS, m/z: 425.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.26˜7.36(m, 2H), 6.96˜ 7.17(m, 2H), 6.59˜6.73(m, 3H), 5.17(d, 1H, J=5.29Hz), 4.29(d, 1H, J=5.29Hz), 4.24(s, 2H), 3.63(q, 2H, 6.92Hz), 2.10(s, 3H), 1.34(s, 3H), 1.29(s, 3H), 1.17(t, 3H, J=7.12 Hz) MS, m/z: 387.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 - 1 H NMR(200MHz, CDCl 3 ) δ 7.11˜7.36(m, 4H), 6.80˜ 1H, J=4.88Hz), 3.64(q, 2H, 6.92Hz), 1.36(s, 3H), 1.32(s, 3H), 1.18(t, 3H, J=6.92Hz), 1.01(s, 9H) MS, m/z: 443.5 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 455.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 427.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 479.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 467.5 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 455.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.59˜7.60(m, 1H), 7.18˜ 7.56(m, 3H), 6.92˜7.16(m, 2H), 6.63˜6.88(m, 3H), 6.45˜ 6.52(m, 1H), 5.37(d, 1H, J=5.70Hz), 4.45(d, 1H, J=5.70 Hz), 4.24(s, 2H), 3.68(q, 2H, J=6.92Hz), 1.39(s, 3H), 1.35(s, 3H), 1.16˜1.26(m, 3H); MS, m/z: 439.4 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 401.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 457.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 469.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 441.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 493.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 481.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 469.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 453.5 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 415.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.30˜7.37(m, 2H), 6.96˜ 7.05(m, 2H), 6.59˜6.67(m, 3H), 5.18(d, 1H, J=5.29Hz), 4.30(d, 1H, J=5.29Hz), 4.24(s, 2H), 3.55(t, 2H, J=6.31 Hz), 2.24(s, 2H), 1.40˜1.54(m, 4H), 1.35(s, 3H), 1.28(s, 3H), 1.03(s, 9H), 0.90˜0.93(m, 3H); MS, m/z: 471.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 483.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.30˜7.37(m, 2H), 6.96˜ 7.05(m, 2H), 6.63˜6.68(m, 3H), 5.70(d, 1H, J=1.20Hz), 5.20(d, 1H, J=5.09Hz), 4.26(d, 1H, J=5.09Hz), 4.24(s, 2H), 3.61˜3.64(m, 2H), 2.16(d, 3H, J=1.02Hz), 1.88(d, 3H, J=1.42Hz), 1.35(s, 3H), 1.29(s, 3H), 0.90(t, 3H, J=6.90Hz); MS, m/z: 455.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.04(d, 2H, J=8.34Hz), 7.30˜ 7.57(m, 5H), 6.96˜7.04(m, 3H), 6.59˜6.76(m, 3H), 5.41(d, 1H, J=5.09Hz), 4.41(d, 1H, J=5.09Hz), 4.24(s, 2H), 3.63˜3.70(m, 2H), 1.31˜1.59(m, 4H), 1.40(s, 3H), 1.38(s, 3H), 0.86(t, 3H, J=7.12Hz); MS, m/z: 477.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.93(d, 2H, J=8.14Hz), 7.20˜ 7.37(m, 4H), 6.96˜7.05(m, 2H), 6.58˜6.76(m, 3H), 5.40(d, 1H, 5.09Hz), 4.41 (d, 1H, J=5.09Hz), 4.24(s, 2H), 3.62˜3.68(m, 2H), 2.40(s, 3H), 1.22˜1.55(m, 4H), 1.39(s, 3H), 1.37(s, 3H), 0.86(t, 3H, J=7.33Hz); MS, m/z: 491.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.98(d, 2H, J=8.95Hz), 7.26˜ 7.92(m, 2H), 6.86˜7.05(m, 4H), 6.57˜6.76(m, 3H), 5.39(d, 1H, J=5.09Hz), 4.40(d, 1H, J=5.09Hz), 4.24(s, 2H), 3.85(s 3H), 3.62˜3.83(m, 2H), 1.22˜1.56(m, 4H), 1.39(s, 3H), 1.37(s, 3H), 0.90(t, 3H, J=4.27Hz); MS, m/z: 507.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 495.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.82(dd, 1H, J=1.02Hz, J=3.87Hz), 7.57(dd, 1H, J=1.02Hz, J=3.87Hz), 7.26˜ 7.37(m, 2H), 6.97˜7.13(m, 3H), 6.55˜6.74(m, 3H), 5.36(d, 1H, J=5.70Hz), 4.45(d, 1H, J=5.70Hz), 4.24(s, 2H), 3.65(t, 2H, J=6.10Hz), 1.22˜1.55(m, 4H), 1.40(s, 3H), 1.36(s, 3H), 0.86(t, 3H, J=7.12Hz); MS, m/z: 483.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.59(d, 1H, J=1.02Hz), 7.30˜ 7.37(m, 2H), 7.18(d, 1H, J=3.46Hz), 6.97˜7.05(m, 2H), 6.54˜6.74(m, 3H), 6.49˜6.51(m, 1H), 5.37(d, 1H, J=5.49 Hz), 4.42(d, 1H, J=5.49Hz), 4.24(s, 2H), 3.64(t, 2H, J=6.31Hz), 1.22˜1.55(m, 4H), 1.39(s, 3H), 1.35(s, 3H), 0.87(t, 3H, J=7.32Hz); MS, m/z: 467.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.26˜7.32(m, 7H), 6.95˜ 7.04(m, 2H), 6.47˜6.72(m, 3H), 5.28(d, 1H, J=4.68Hz), 4.17(s, 2H), 4.40(d, 1H, J=4.68Hz), 4.17(s, 2H), 2.24(s, 2H), 1.39(s, 3H), 1.33(s, 3H), 1.01 (s, 9H); MS, m/z: 505.6 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 517.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 489.5 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.93(d, 2H, J=7.94Hz), 7.21˜ 7.86(m, 9H), 6.96˜7.04(m, 2H), 6.49˜6.76(m, 3H), 5.51(d, 1H, J=4.88Hz), 4.75(s, 2H), 4.56(d, 1H, J=4.88 Hz), 4.17(s, 2H), 2.41(s, 2H), 2.41(s, 3H), 1.43(s, 3H), 1.40(s, 3H); MS, m/z: 525.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.00(d, 2H, J=8.75Hz), 7.26˜ 7.29(m, 7H), 6.88˜7.04(m, 4H), 6.51˜6.76(m, 3H), J=4.88Hz), 4.75(s, 2H), 4.50(d, 1H, J=4.88 Hz), 4.17(s, 2H), 3.85(s, 3H), 1.43(s, 3H), 1.40(s, 3H); MS, m/z: 541.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ , 8.02˜8.09(m, 2H), 7.27˜ 7.35(m, 7H), 7.00˜7.15(m, 4H), 6.49˜6.77(m, 3H), 5.50(d, 1H, J=4.68Hz), 4.75(s, 2H), 4.55(d, 1H, J=4.68 Hz), 4.17(s, 2H), 1.44(s, 3H), 1.41(s, 3H); MS, m/z: 529.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.82˜7.84(m, 1H), 7.57˜ 7.60(m, 1H), 7.26˜7.33(m, 7H), 6.96˜7.13(m, 3H), 5.46(d, 1H, J=5.29Hz), 4.73(s, 2H), 4.60(d, 1H, J=5.29 Hz), 4.17(s, 2H), 1.43(s, 3H), 1.39(s, 3H); MS, m/z: 517.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.59˜7.60(m, 1H), 7.20˜ 7.35(m, 7H), 7.18˜7.20(m, 1H), 6.96˜7.05(m, 2H), 6.49˜ 6.75(m, 4H), 5.47(d, 1H, J=5.09Hz), 4.73(s, 2H), 4.56(d, 1H, J=5.09Hz), 4.17(s, 2H), 1.43(s, 3H), 1.38(s, 3H); MS, m/z: 501.5 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 519.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 531.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 503.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 525.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 539.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 555.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 543.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 531.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 515.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 469.9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 525.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 537.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 509.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 531.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 545.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 561.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 549.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 537.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 521.6 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.12˜7.26(m, 4H), 6.59˜ 6.73(m, 3H), 5.22(d, 1H, J=5.49Hz), 4.28(d, 1H, J=5.49 Hz), 4.22(s, 2H), 3.40(s, 3H), 2.33(s, 3H), 2.11(s, 3H), 1.35(s, 3H), 1.29(s, 3H); MS, m/z: 369.4 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.12˜7.27(m, 4H), 6.57˜ 6.73(m, 3H), 5.24(d, 1H, J=10Hz), 4.33(d, 1H, J=6.10 Hz), 4.22(s, 2H), 3.36(s, 3H), 2.33(s, 3H), 2.27(s, 2H), 1.36(s, 3H), 1.29(s, 3H), 1.05(s, 9H); MS, m/z: 425.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.12˜7.28(m, 4H), 6.56˜ 6.73(m, 3H), 5.22(d, 1H, J=5.9Hz), 4.29(d, 1H, J=5.9Hz), 4.22(s, 2H), 3.39(s, 3H), 2.98˜2.37(m, 1H), 1.28˜ 1.93(m, 10H), 1.34(s, 3H), 1.28(s, 3H); MS, m/z: 437.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.12˜7.27(m, 4H), 6.58˜ 216.73(m, 3H), 5.72˜5.73(m, 1H), 5.25(d, 1H, J=5.49Hz), 4.29(d, 1H, J=5.49Hz), 4.22(s, 2H), 3.43(s, 3H), 2.33(s, 3H), 2.18(d, 3H, J=1.20Hz), 1.90(d, 3H, J=1.20Hz), 1.36(s, 3H), 1.30(s, 3H); MS, m/z: 409.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.04˜8.09(m, 2H), 7.41˜ 7.58(m, 3H), 7.07˜7.37(m, 4H), 6.61˜6.78(m, 3H), 5.48(d, 1H, J=5.70), 4.45(d, 1H, J=5.70Hz), 4.23(s, 2H), 3.47(s, 3H), 2.33(s, 3H), 1.42(s, 3H), 1.39(s, 3H); MS, m/z: 431.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.94(d, 2H, J=8.34Hz), 7.12˜ 7.28(m, 6H), 6.60˜6.77(m, 3H), 5.46(d, 1H, J=5.70Hz), 4.44(d, 1H, J=5.70Hz), 4.23(s, 2H), 3.46(s, 3H), 2.41(s, 3H), 2.33(s, 3H), 1.40(s, 3H), 1.38(s, 3H); MS, m/z: 445.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.00(dd, 2H, J=2.04Hz, J=6.92Hz), 7.11˜7.26(m, 4H), 6.89˜6.85(m, 2H), 6.65˜ 6.77(m, 3H), 5.43(d, 1H, J=5.49Hz), 4.41(d, 1H, J=5.49 Hz), 4.22(s, 2H), 3.86(s, 3H), 3.46(s, 3H), 2.32(s, 3H), 1.40(s, 3H), 1.37(s, 3H); MS, m/z: 461.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.03˜8.10(m, 2H), 7.07˜ 7.28(m, 6H), 6.59˜6.77(m, 3H), 5.45(d, 1H, J=5.48Hz), 4.43(d, 1H, J=5.49Hz), 4.23(s, 2H), 3.46(s, 3H), 2.33(s, 3H), 1.41(s, 3H), 1.38(s, 3H); MS, m/z: 449.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.84(dd, 1H, J=1.22Hz, J=3.87Hz), 7.58(dd, 1H, J=1.22Hz, J=3.87Hz), 7.09˜ 7.28(m, 5H), 6.58˜6.76(m, 3H), 5.41(d, 1H, J=6.31Hz), 4.49(d, 1H, J=6.31Hz), 4.23(s, 2H), 3.44(s, 3H), 2.33(s, 3H), 1.41(s, 3H), 1.36(s, 3H); MS, m/z: 437.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.60(dd, 1H, J=0.81Hz, J=1.83Hz), 7.12˜7.27(m, 5H), 6.58˜6.75(m, 3H), 6.51 (dd, 1H, J=1.83Hz, J=3.46Hz), 5.42(d, 1H, J=6.10 Hz), 4.46(d, 1H, J=6.10Hz), 4.22(s, 2H), 3.43(s, 3H), 2.33(s, 3H), 1.40(s, 3H), 1.35(s, 3H); MS, m/z: 421.5 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 383.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 439.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 351.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 423.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 463.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 451.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 435.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 397.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 453.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 465.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 437.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 473.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 489.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 477.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 465.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 449.5 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 411.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 467.6 
               
            
           
           
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 479.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.16˜7.26(m, 4H), 7.06˜ 7.09(m, 2H), 6.71˜6.98(m, 3H), 5.68(d, 1H, J=1.42Hz), 5.19(d, 1H, J=4.68Hz), 4.22(d, 1H, J=4.68Hz), 4.17(s, 2H), 3.59˜3.68(m, 2H), 2.26(s, 3H), 2.17(s, 3H), 1.89(s, 3H), 1.35(s, 3H), 1.30(s, 3H), 1.19˜1.59(m, 4H), 0.90(t, 3H, J=7.32Hz); MS, m/z: 451.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.01˜8.05(m, 2H), 7.26˜ 7.57(m, 3H), 7.07˜7.23(m, 4H), 6.77˜6.83(m, 3H), 5.41(d, 1H, J=4.55Hz), 4.40(d, 1H, J=4.55Hz), 4.20(s, 2H), 3.21˜3.70(s, 2H), 2.28(s, 3H), 1.40(s, 3H), 1.38(s, 3H), 1.19˜1.57(m, 4H), 0.86(t, 3H, J=7.32Hz); MS, m/z: 473.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 487.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.93˜7.98(m, 2H), 6.98˜ 7.26(m, 6H), 6.79˜6.97(m, 3H), 5.35(d, 1H, J=4.68Hz), 4.30(d, 1H, J=4.68Hz), 4.16(s, 2H), 3.84(s, 3H), 3.65˜ 3.76(m, 2H), 2.17(s, 3H), 1.39(s, 3H), 1.37(s, 3H), 1.19˜ 1.52(m, 4H), 0.86(t, 3H, J=7.12Hz); MS, m/z: 503.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 8.00˜8.07(m, 2H), 7.06˜ 7.25(m, 6H), 6.78˜6.87(m, 3H), 5.38(d, 1H, J=4.88Hz), 4.37(d, 1H, J=4.88Hz), 4.18(s, 2H), 3.62˜3.70(m, 2H), 2.27(s, 3H), 1.40(s, 3H), 1.37(s, 3H), 1.19˜1.56(m, 4H), 0.87(t, 3H, J=7.12Hz); MS, m/z: 491.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.81 (dd, 1H, J=1.42Hz, J=3.87Hz), 7.57(dd, 1H, J=1.42Hz, J=3.87Hz), 7.08˜ 7.26(m, 5H), 6.72˜7.06(m, 3H), 5.33(d, 1H, J=5.49Hz), 4.40(d, 1H, J=5.49Hz), 4.18(s, 2H), 3.66(t, 2H, J=6.31 Hz), 2.26(s, 3H), 1.39)s, 3H), 1.36(s, 3H), 1.19˜1.56(m, 4H), 0.82(t, 3H, J=7.12Hz); MS, m/z: 479.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   1 H NMR(200MHz, CDCl 3 ) δ 7.58(s, 1H), 7.01˜7.18(m, 7H), 6.75˜6.80(m, 1H), 6.49˜6.51(m, 1H), 5.33(d, 1H, J=5.09Hz), 4.33(d, 1H, J=5.09Hz), 4.16(s, 2H), 3.65(t, 2H, J=6.71Hz), 2.21(s, 3H), 1.38(s, 3H), 1.35(s, 3H), 1.18˜ 1.56(m, 4H), 0.87(t, 3H, J=7.12Hz); MS, m/z: 463.5 
               
            
           
           
               
               
               
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 445.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 501.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 513.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 485.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 507.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 521.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 537.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 525.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 513.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 497.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 459.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 515.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 527.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 499.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 521.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 535.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 551.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 539.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 527.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 511.6 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 465.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 521.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 533.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 505.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 527.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 541.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 557.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 545.7 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 533.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 MS, m/z: 517.6 
               
               
                   
               
            
           
         
       
     
     The following specific formulations comprising the compound of this invention as an active ingredient are intended to be illustrative of the invention and should not be construed as limiting the scope of the invention. 
     FORMULATION EXAMPLE 1 
     Tablet (Direct Pressure) 
     5.0 mg of active ingredient were sieved, and 14.1 mg of lactose, 0.8 mg of crosspovidone USNF and 0.1 mg of magnesium stearate were mixed and then pressured to prepare tablets. 
     FORMULATION EXAMPLE 2 
     Tablet (Wet Granulation) 
     5.0 mg of active ingredient was sieved, and 16.0 mg of lactose and 4.0 mg of starch were mixed. 0.3 mg of polysorbate 80 in purified water was added to the mixture and the resultant was treated to form fine granules. After drying, the fine granules were sieved and 2.7 mg of colloidal silicone dioxide and 2.0 mg of magnesium stearate were mixed. The fine granules were pressured to prepare tablets. 
     FORMULATION EXAMPLE 3 
     Powder and Capsule 
     5.0 mg of active ingredient was sieved, and 14.8 mg of lactose, 10.0 mg of polyvinyl pyrrolidone and 0.2 mg of magnesium stearate were mixed. The mixture was introduced into No. 5 gelatin capsule by use of a suitable device. 
     FORMULATION EXAMPLE 4 
     Injections 
     100 mg of active ingredient, 180 mg of mannitol, 26 mg of Na 2 HPO 4 ·12H 2 O and 2974 mg of distilled water were employed to produce injections. 
     The inhibitory effect of the present compounds on lipid peroxidation induced by iron was evaluated as follows: 
    
    
     EXPERIMENTAL EXAMPLE 
     Inhibitory Effect on Lipid Peroxiation 
     Rat brain was homogenized in Krebs buffer (15 mM HEPES, 10 mM glucose, 140 mM NaCl, 3.6 mM KCl, 1.5 mM CaCl 2 , 1.4 mM KH 2 PO 4  and 0.7 mM MgCl, pH 7.4) and centrifuged at 12,000 rpm to obtain the supernatant serving as a raw material of lipid. To the brain homogenates, FeCl 2  was added to give a final concentration of 400 μM and allowed to stand for 30 min at 37° C. for promoting oxidation. Each of the compounds to be tested was added to give a concentration of 12.5 μM and a control group was solely added with dimethylsulfoxide (DMSO). 
     When iron is added to brain homogenates, oxidation is promoted to increase the amount of malondialdehyde (MDA) as lipid peroxidation product. Therefore, in this Example, the level of lipid peroxidation was evaluated according to MDA measurement method. In general MDA measurement, the test sample is reacted with TBA (2-thiobarbituric acid) and the absorbance at 530 nm was measured. However, since such process includes a boiling step, it is unsuitable for dealing with test samples in large quantity. Therefore, in this Example, N-methyl-2-phenylindole was used as a color developing reagent in place of TBA so as to avoid boiling step. Two molecules of N-methyl-2-phenylindole are reacted with one molecule of MDA to form chromophore that shows its maximum absorption at 586 nm (absorption measurement with Bioxytech LPO-586 Kit). The inhibitory effect on lipid peroxidation of test compounds was evaluated by calculating the decreased level of MDA in percentage based on the amount of MDA in the control group. For the test compounds showing more than 80% inhibitory effect, the concentration-lipid peroxidation inhibition curves were plotted with reference to the decrease rate of MDA amount based on the amount of MDA in the control group and their IC 50  values was calculated through least linear regression analysis. The results are summarized in Table 4. 
     In addition, the representative antioxidants commercialized such as Promethazine, Trolox, Probucol and N-propyl gallate were examined in terms of 50% inhibition concentration (IC 50 ) according to the above procedure and the results are shown in Table 4. 
     
       
         
           
               
               
               
               
               
             
               
                   
                 TABLE 4 
               
               
                   
                   
               
               
                   
                 Compound No. 
                 IC 50  (μM) 
                 Compound No. 
                 IC 50  (μM) 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 5-49 
                 2.85 
                 5-50 
                 4.90 
               
               
                   
                 5-51 
                 5.20 
                 5-52 
                 0.98 
               
               
                   
                 5-53 
                 1.80 
                 5-55 
                 2.61 
               
               
                   
                 5-57 
                 4.37 
                 5-63 
                 2.46 
               
               
                   
                 5-64 
                 2.57 
                 5-65 
                 1.13 
               
               
                   
                 5-67 
                 6.06 
                 5-68 
                 1.39 
               
               
                   
                 5-69 
                 1.42 
                 5-70 
                 1.15 
               
               
                   
                 5-71 
                 1.70 
                 5-72 
                 7.39 
               
               
                   
                 5-73 
                 2.85 
                 5-74 
                 3.60 
               
               
                   
                 5-77 
                 2.50 
                 5-78 
                 1.14 
               
               
                   
                 5-79 
                 0.79 
                 5-80 
                 1.08 
               
               
                   
                 5-97 
                 5.34 
                 5-98 
                 5.30 
               
               
                   
                 5-100 
                 3.89 
                 5-101 
                 6.03 
               
               
                   
                 5-103 
                 5.10 
                 5-104 
                 4.01 
               
               
                   
                 5-106 
                 5.51 
                 5-289 
                 1.32 
               
               
                   
                 5-290 
                 3.02 
                 5-292 
                 3.25 
               
               
                   
                 5-293 
                 3.68 
                 5-295 
                 1.29 
               
               
                   
                 5-296 
                 5.85 
                 5-298 
                 6.07 
               
               
                   
                 5-300 
                 1.36 
                 5-306 
                 4.12 
               
               
                   
                 5-307 
                 3.55 
                 5-308 
                 4.75 
               
               
                   
                 5-309 
                 2.90 
                 5-310 
                 1.10 
               
               
                   
                 5-311 
                 1.19 
                 5-312 
                 4.13 
               
               
                   
                 5-313 
                 1.44 
                 5-315 
                 3.43 
               
               
                   
                 5-318 
                 5.27 
                 5-464 
                 3.81 
               
               
                   
                 5-465 
                 6.41 
                 5-466 
                 1.20 
               
               
                   
                 5-467 
                 3.60 
                 5-468 
                 4.27 
               
               
                   
                 5-469 
                 4.38 
                 5-470 
                 4.15 
               
               
                   
                 5-471 
                 4.85 
                 5-472 
                 3.90 
               
               
                   
                 5-473 
                 2.72 
                 5-474 
                 3.45 
               
               
                   
                 5-476 
                 1.35 
                 5-477 
                 3.63 
               
               
                   
                 5-478 
                 6.21 
                 5-480 
                 5.55 
               
               
                   
                 5-485 
                 2.66 
                 5-486 
                 0.91 
               
               
                   
                 5-490 
                 2.24 
                 5-495 
                 2.04 
               
               
                   
                 5-510 
                 9.45 
                 5-511 
                 0.12 
               
               
                   
                 5-512 
                 3.60 
                 5-514 
                 2.39 
               
               
                   
                 5-519 
                 4.60 
                 5-562 
                 6.47 
               
               
                   
                 5-564 
                 4.33 
                 5-566 
                 5.73 
               
               
                   
                 5-1126 
                 2.56 
                 5-1131 
                 9.38 
               
               
                   
                 5-1223 
                 4.29 
                 5-1231 
                 1.00 
               
               
                   
                 5-1235 
                 1.00 
                 5-1261 
                 4.7 
               
               
                   
                 5-1482 
                 5.27 
                 5-1483 
                 2.39 
               
               
                   
                 5-1489 
                 3.33 
                 5-1490 
                 3.04 
               
               
                   
                 5-1515 
                 2.23 
                 5-1516 
                 6.34 
               
               
                   
                 5-1520 
                 3.10 
                 5-1552 
                 5.43 
               
               
                   
                 5-1558 
                 3.37 
                 5-1560 
                 2.31 
               
               
                   
                 5-1561 
                 2.89 
                 5-1562 
                 3.03 
               
               
                   
                 5-1563 
                 2.05 
                 5-1568 
                 4.09 
               
               
                   
                 5-1569 
                 3.41 
                 5-1570 
                 3.03 
               
               
                   
                 5-1762 
                 1.80 
                 5-1765 
                 5.13 
               
               
                   
                 5-1767 
                 2.63 
                 5-1768 
                 2.73 
               
               
                   
                 5-1769 
                 5.97 
                 5-1770 
                 3.11 
               
               
                   
                 5-1797 
                 3.56 
                 5-1799 
                 6.01 
               
               
                   
                 5-1800 
                 3.90 
                 5-1802 
                 4.12 
               
               
                   
                 5-1806 
                 5.85 
                 5-1808 
                 3.97 
               
               
                   
                 5-1809 
                 6.36 
                 5-1810 
                 4.34 
               
               
                   
                 5-1831 
                 2.71 
                 5-1832 
                 1.09 
               
               
                   
                 5-1834 
                 1.29 
                 5-1835 
                 1.14 
               
               
                   
                 5-1836 
                 1.16 
                 5-1837 
                 4.25 
               
               
                   
                 5-1838 
                 1.31 
                 5-1839 
                 1.07 
               
               
                   
                 5-1840 
                 1.03 
               
               
                   
                 Promethazine 
                 10.2 
                 Trolox 
                 24.6 
               
               
                   
                 Probucol 
                 18.2 
                 N-propyl gallate 
                 25.0 
               
               
                   
                   
               
            
           
         
       
     
     As shown in Table 4, the present compounds exhibit inhibitory effect on iron-induced lipid peroxidation. Of them, several compounds showed inhibition rate of at below 2.0 μM, thus showing high inhibition potency. 
     As described previously, although the conventional processes perform multi-step reactions in a solution and require several treatment and purification steps after several reactions, the process of the present invention for preparing 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative according to parallel synthesis on solid-phase makes it possible to significantly reduce the number of treatments and purification steps to a single step, thereby enabling to construct a large amount of benzopyran library in a short period of time. In particular, the present process comprises: the first step for producing N-substituted carbamate resin of the formula (2); the second step for producing 2,2-dimethyl-3-hydroxy-4-alkoxy-6-alkylamino benzopyran resin of the formula (3); the third step for producing 2,2-dimethyl-3-substituted-4-alkoxy-6-alkylamino benzopyran resin of the formula (4); and the fourth step for producing, the compound of interest of the formula (5) by use of dichloromethane solution containing TFA or an organic solvent containing an organic acid. The present process is very useful in mass production of 6-amino-2,2-dimethyl-3,4,6° trisubstituted benzopyran derivatives. 
     Therefore, the present invention establishes the technology for construction of 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran library according to parallel synthesis on solid-phase, which highlights the applicability of combinatorial chemical synthesis technology. Furthermore, the present invention permits to easily screen and optimize structure and function of the lead compound with novel structure useful in developing drugs for preventing and treating diseases of nervus craniales induced by accumulation of oxidized molecules through lipid peroxidation in nerve cells such as apoplexy and dementia, as well as inflammatory diseases such as arthritis, cardiac infarction and acute or chronic tissue injury.