Patent Publication Number: US-2021171948-A1

Title: Compositions and methods for targeting glypican-2 in the treatment of cancer

Description:
RELATED APPLICATIONS 
     This application claims benefit of, and priority to, U.S. Application No. 62/945,436, filed on Dec. 9, 2019, the entire contents of which are incorporated herein by reference. 
    
    
     TECHNICAL FIELD 
     The disclosure relates to the use of siRNA based therapeutics for the treatment of cancer. 
     INCORPORATION-BY-REFERENCE OF SEQUENCE LISTING 
     The contents of the text file named “SHEP_003_001US_SeqList_ST25”, which was created on Dec. 8, 2020 and is 845 KB in size, are hereby incorporated by reference in their entirety. 
     BACKGROUND 
     Cancer is a proliferative disease in which the cells of a subject grow abnormally and in an uncontrolled way, in some cases leading to the death of the subject. There are many independent events and causes which can lead to cancer, and many different cell types and tissues that can give rise to cancers. As such, treatments developed for one type of cancer may not work on another type of cancer. Despite many years of research, and a plethora of treatments available to cancer sufferers, there is still a long felt need in the art for additional cancer therapies. Glypican-2 (Glypican 2, GPC2, or GPC-2) is a cell surface protein that belongs to a family of six proteoglycans. These proteins play diverse roles in signaling and cancer cell growth. Although GPC2 was initially thought to be solely expressed during nervous system development, GPC2 is also expressed on the surface of some types of cancer cells, such as neuroblastoma cells. The disclosure provides additional methods for the treatment of cancer by targeting GPC2 mRNA for degradation via RNA interference. 
     SUMMARY 
     The disclosure provides nanoparticles comprising small interfering RNAs (siRNAs), wherein the siRNA comprises a sense region and anti-sense region complementary to said sense region such that the sense region and the anti-sense region together form an RNA duplex, and wherein the sense region comprises a sequence at least 70% identical to a glypican-2 (GPC2) mRNA sequence. 
     In some embodiments of the nanoparticles of the disclosure, the sense region comprises a sequence that is identical to the GPC2 mRNA sequence. 
     In some embodiments of the nanoparticles of the disclosure, the siRNA is capable of inducing RNAi-mediated degradation of the GPC2 mRNA. 
     In some embodiments of the nanoparticles of the disclosure, the sense region is encoded by a first single stranded RNA molecule and the anti-sense region is encoded by a second single stranded RNA molecule. In some embodiments, the first single stranded RNA molecule comprises a first 3′ overhang. In some embodiments, the second single stranded RNA molecule comprises a second 3′ overhang. In some embodiments, the first and second 3′ overhangs comprise a dinucleotide. In some embodiments, the dinucleotide comprises thymidine-thymidine (dT-dT) or Uracil-Uracil (UU). In some embodiments, the RNA duplex is between 17 and 24 nucleotides in length. In some embodiments, the RNA duplex is 19 nucleotides in length. In some embodiments, the GPC2 mRNA sequence comprises SEQ ID NO: 1 or SEQ ID NO: 2. In some embodiments, the sense region comprises a sequence selected from the group listed in Table 1 and Table 2. In some embodiments, the siRNA comprises a sequence selected from the group consisting of SEQ ID NOs: 3-232. In some embodiments, anti-sense region comprises a sequence selected from the group listed in Table 1 and Table 2. In some embodiments, the sense region comprises a sequence of CCUGCUUGGACCUCGAUAA (SEQ ID NO: 3), CUCAGUAGCCCAGCACUCU (SEQ ID NO: 4) or CUCCUUUCUGGUUCACACA (SEQ ID NO: 5). In some embodiments, the sense region comprises a sequence of CCUGCUUGGACCUCGAUAA (SEQ ID NO: 3) and the anti-sense region comprises a sequence of UUAUCGAGGUCCAAGCAGG (SEQ ID NO: 6). In some embodiments, the sense region comprises a sequence of CUCAGUAGCCCAGCACUCU (SEQ ID NO: 4) and the anti-sense region comprises a sequence of AGAGUGCUGGGCUACUGAG (SEQ ID NO: 7). In some embodiments, the sense region comprises a sequence of CUCCUUUCUGGUUCACACA (SEQ ID NO: 5) and the anti-sense region comprises a sequence of UGUGUGAACCAGAAAGGAG (SEQ ID NO: 8). 
     In some embodiments of the nanoparticles of the disclosure, the siRNA comprises at least one modified nucleotide. In some embodiments, the at least one modified nucleotide increases stability of the RNA duplex. In some embodiments, the at least one modified nucleotide comprises a locked nucleic acid (LNA). 
     In some embodiments of the nanoparticles of the disclosure, the nanoparticle comprises a liposome, a micelle, a polymer-based nanoparticle, a lipid-polymer based nanoparticle, a nanocrystal, a carbon nanotube based nanoparticle or a polymeric micelle. In some embodiments, the polymer-based nanoparticle comprises a multiblock copolymer, a diblock copolymer, a polymeric micelle or a hyperbranched macromolecule. In some embodiments, the polymer-based nanoparticle comprises a multiblock copolymer a diblock copolymer. In some embodiments, the polymer-based nanoparticle comprises a poly(lactic-co-glycolic acid) PLGA polymer. 
     In some embodiments of the nanoparticles of the disclosure, the nanoparticle comprises a targeting agent. In some embodiments, the targeting agent comprises a peptide ligand, a nucleotide ligand, a polysaccharide ligand, a fatty acid ligand, a lipid ligand, a small molecule ligand, an antibody, an antibody fragment, an antibody mimetic or an antibody mimetic fragment. In some embodiments, the polysaccharide ligand comprises hyaluronic acid. In some embodiments, the targeting agent binds to the surface of a cell of the cancer of the subject. 
     In some embodiments of the nanoparticles of the disclosure, the nanoparticle further comprises a chemotherapeutic agent. In some embodiments, the chemotherapeutic agent comprises a platinum based antineoplastic agent, a DNA alkylating agent, a DNA intercalating agent, or a topoisomerase inhibitor. In some embodiments, the platinum based antineoplastic agent is Cisplatin or Carboplatin. In some embodiments, the DNA alkylating agent is Cyclophosphamide. In some embodiments, the DNA intercalating agent is Doxorubicin. In some embodiments, the topoisomerase inhibitor is Etoposide or Topotecan. 
     The disclosure provides pharmaceutical compositions comprising the nanoparticles of the disclosure, and a pharmaceutically acceptable carrier, diluent or excipient. In some embodiments, the pharmaceutical composition further comprises a chemotherapeutic agent. In some embodiments the nanoparticle further comprises a chemotherapeutic agent. In some embodiments, the chemotherapeutic agent comprises a platinum based antineoplastic agent, a DNA alkylating agent, a DNA intercalating agent, or a topoisomerase inhibitor. In some embodiments, the platinum based antineoplastic agent is Cisplatin or Carboplatin. In some embodiments, the DNA alkylating agent is Cyclophosphamide. In some embodiments, the DNA intercalating agent is Doxorubicin. In some embodiments, the topoisomerase inhibitor is Etoposide or Topotecan. In some embodiments, the platinum based antineoplastic agent is Cisplatin or Carboplatin. In some embodiments, the DNA alkylating agent is Cyclophosphamide. In some embodiments, the DNA intercalating agent is Doxorubicin. In some embodiments, the topoisomerase inhibitor is Etoposide or Topotecan. 
     The disclosure provides kits comprising the nanoparticles or pharmaceutical compositions of the disclosure. In some embodiments, the kits further comprise instructions for administrating the nanoparticles or pharmaceutical compositions to a subject. 
     The disclosure provides methods of treating a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the nanoparticles of the disclosure. In some embodiments, the methods comprise administering a chemotherapeutic agent to the subject. 
     The disclosure provides methods of treating a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the pharmaceutical compositions of the disclosure to the subject. In some embodiments, the methods comprise administering a chemotherapeutic agent to the subject. 
     In some embodiments of the methods of the disclosure, the chemotherapeutic agent comprises a platinum based antineoplastic agent, a DNA alkylating agent, a DNA intercalating agent, or a topoisomerase inhibitor. 
     In some embodiments of the methods of the disclosure, the nanoparticles or the pharmaceutical composition is administered parenterally. 
     The disclosure provides methods of treating a cancer in a subject, comprising administering to the subject a therapeutically effective amount of a composition comprising a nanoparticle, the nanoparticle comprising a small interfering RNA (siRNA), wherein the siRNA comprises a sense region and anti-sense region complementary to the sense region that together form an RNA duplex, wherein the sense region comprises a sequence at least 70% identical to a glypican-2 (GPC2) mRNA sequence of SEQ ID NO: 1 or SEQ ID NO: 2. 
     In some embodiments of the methods of the disclosure, the sense region comprises a sequence that is identical to the GPC2 mRNA sequence. In some embodiments, the siRNA is capable of inducing RNAi-mediated degradation of a GPC2 mRNA in a cell of the cancer. In some embodiments, the sense region is encoded by a first single stranded RNA molecule and the anti-sense region is encoded by a second single stranded RNA molecule. In some embodiments, the first and second single stranded RNA molecules comprise 3′ overhangs. In some embodiments, the 3′ overhangs comprise thymidine-thymidine (dT-dT) or Uracil-Uracil (UU). In some embodiments, the RNA duplex is between 17 and 24 nucleotides in length. In some embodiments, the RNA duplex is 19 nucleotides in length. In some embodiments, the sense region comprises a sequence selected from the group listed in Table 1 or Table 2. In some embodiments, the siRNA comprises a sequence selected from the group consisting of SEQ ID NOs: 3-232. In some embodiments, the anti-sense region comprises a sequence selected from the group listed in Table 1 or Table 2. In some embodiments, the sense region comprises a sequence of CCUGCUUGGACCUCGAUAA (SEQ ID NO: 3), CUCAGUAGCCCAGCACUCU (SEQ ID NO: 4) or CUCCUUUCUGGUUCACACA (SEQ ID NO: 5). In some embodiments, the sense region comprises a sequence of CCUGCUUGGACCUCGAUAA (SEQ ID NO: 3) and the anti-sense region comprises a sequence of UUAUCGAGGUCCAAGCAGG (SEQ ID NO: 6). In some embodiments, the sense region comprises a sequence of CUCAGUAGCCCAGCACUCU (SEQ ID NO: 4) and the anti-sense region comprises a sequence of AGAGUGCUGGGCUACUGAG (SEQ ID NO: 7). In some embodiments, the sense region comprises a sequence of CUCCUUUCUGGUUCACACA (SEQ ID NO: 5) and the anti-sense region comprises a sequence of UGUGUGAACCAGAAAGGAG SEQ ID NO: 8). 
     In some embodiments of the methods of the disclosure, the siRNA comprises at least one modified nucleotide. In some embodiments, the at least one modified nucleotide increases stability of the RNA duplex. In some embodiments, the at least one modified nucleotide comprises a locked nucleic acid (LNA). 
     In some embodiments of the methods of the disclosure, the methods comprise administering a chemotherapeutic agent. In some embodiments, the chemotherapeutic agent comprises a platinum based antineoplastic agent, a DNA alkylating agent, a DNA intercalating agent, or a topoisomerase inhibitor. In some embodiments, the platinum based antineoplastic agent is Cisplatin or Carboplatin. In some embodiments, the DNA alkylating agent is Cyclophosphamide. In some embodiments, the DNA intercalating agent is Doxorubicin. In some embodiments, the topoisomerase inhibitor is Etoposide or Topotecan. In some embodiments, the platinum based antineoplastic agent is Cisplatin or Carboplatin. In some embodiments, the DNA alkylating agent is Cyclophosphamide. In some embodiments, the DNA intercalating agent is Doxorubicin. In some embodiments, the topoisomerase inhibitor is Etoposide or Topotecan. 
     In some embodiments of the methods of the disclosure, the pharmaceutical composition is administered at the same time as the chemotherapeutic agent. In some embodiments, the chemotherapeutic agent is formulated in the composition comprising the nanoparticle. In some embodiments, the chemotherapeutic and the siRNA are formulated in the same nanoparticle. In some embodiments, the pharmaceutical composition is administered in temporal proximity to the chemotherapeutic agent. 
     In some embodiments of the methods of the disclosure, the pharmaceutical composition is administered parenterally. In some embodiments, the parenteral administration is intravenous, subcutaneous, intraperitoneal or intramuscular. In some embodiments, the parenteral administration comprises an intravenous injection or infusion. In some embodiments, the methods further comprise a standard of care for the cancer. In some embodiments of the methods of the disclosure, the cancer expresses GPC2 on a surface of a cell of the cancer. 
     In some embodiments, the cancer is selected from the group consisting of astrocytoma, breast cancer, colorectal cancer, Ewing&#39;s sarcoma, gastric cancer, leiomyosarcoma, liver cancer, lung cancer, mesothelioma, ovarian cancer, pancreatic cancer, renal cancer, rhabdomyosarcoma and neuroblastoma. In some embodiments, the cancer is neuroblastoma. 
     In some embodiments of the methods of the disclosure, administration of the nanoparticle or the pharmaceutical composition decreases viability of a cell of the cancer. In some embodiments, administration of the composition increases apoptosis of cancer cells. In some embodiments, administration of the composition increases sensitivity of the cancer to the chemotherapeutic agent. In some embodiments, administration of the composition increases the effectiveness of the chemotherapeutic agent. In some embodiments, administration of the composition decreases the IC50 of the chemotherapeutic agent. In some embodiments, administration of the composition reduces a side effect of the chemotherapeutic agent. In some embodiments, administration of the composition reduces the therapeutically effective dose of a chemotherapeutic agent. In some embodiments, administration of the composition reduces a sign or a symptom of the cancer. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is a graph showing percentages of cells stained for GPC2 in neuroblastoma (NB) tumor samples and normal tissues (NORMAL). Increased GPC2 protein expression is observed in neuroblastoma tumors when compared to normal tissue. 
         FIG. 2A  is a plot showing knockdown of GPC2 mRNA using siRNA sequences 1-5 from Table 7 in the Ewing&#39;s Sarcoma TC-32 cell line. Expression is compared to a scrambled control siRNA. 
         FIG. 2B  is a plot showing that GPC2 mRNA knockdown in the Ewing&#39;s Sarcoma TC-32 cell line was sustained for at least 96 hours following transfection with siRNAs sequence 3 or 5 from Table 7. Expression is compared to a scrambled control siRNA. 
         FIG. 3A  is a plot showing relative GPC2 mRNA expression following siRNA mediated knockdown of GPC2 in the CHP212, SKNAS and SHSY5Y neuroblastoma cell lines using GPC2 siRNA sequences 3, 5, 12, 13, 14, and 15 from Table 7. Expression is compared to a scrambled control siRNA. 
         FIG. 3B  is a plot showing percent viability of cells following siRNA mediated knockdown of GPC2 in the CHP212, SKNAS and SHSY5Y neuroblastoma cell lines using GPC2 siRNA sequences 3, 5, 12, 13, 14, and 15 from Table 7. Viability is compared to a scrambled control siRNA. 
         FIG. 4A  is a plot showing relative GPC2 mRNA expression following GPC2 mRNA knockdown in the CHP212 neuroblastoma cell line following transfection with GPC2 siRNA sequences 3, 5, 6, 7, 8, 9, 10 and 11 from Table 7 and a scrambled control siRNA. 
         FIG. 4B  is a plot cell viability following GPC2 mRNA knockdown in the CHP212 neuroblastoma cell line following transfection with GPC2 siRNAs 3, 5, 6, 7, 8, 9, 10 and 11 from Table 7 and a scrambled control siRNA. 
         FIG. 5A  is a plot showing relative GPC2 mRNA expression in CHP212 neuroblastoma cells following transfection with GPC2 siRNA sequences 5 and 7 from Table 7 and a scrambled control siRNA. Reduced GPC2 mRNA expression seen with siRNA sequences 5 and 7 was sustained for 72 hours. 
         FIG. 5B  is a plot showing relative GPC2 mRNA expression in SH-SY5Y neuroblastoma cells following transfection with GPC2 siRNA sequences 5 and 7 from Table 7 and a scrambled control siRNA. Reduced GPC2 mRNA expression seen with siRNA sequences 5 and 7 was sustained for 72 hours. 
         FIG. 5C  is a plot showing relative GPC2 mRNA expression in CHLA90 neuroblastoma cells following transfection with GPC2 siRNA sequences 5 and 7 from Table 7 and a scrambled control siRNA. Reduced GPC2 mRNA expression seen with siRNA sequences 5 and 7 was sustained for 72 hours. 
         FIG. 5D  is a plot showing GPC2 protein expression levels in neuroblastoma CHP212 cells following transfection with GPC2 siRNA sequences 5 and 7 from Table 7 and a scrambled control siRNA. Protein expression was measured via flow cytometry of cells fixed and immunostained with a GPC2 antibody, and is reported as Mean Fluorescence (FL1) Intensity. Reduced GPC2 protein expression with siRNA sequences 5 and 7 can be seen at 48 and 72 hours. 
         FIG. 5E  is a plot showing GPC2 protein expression levels in SH-SY5Y neuroblastoma cells following transfection with GPC2 siRNA sequences 5 and 7 from Table 7 and a scrambled control siRNA. Protein expression was measured via flow cytometry of cells fixed and immunostained with a GPC2 antibody, and is reported as Mean Fluorescence (FL1) Intensity. Reduced GPC2 protein expression with siRNA sequences 5 and 7 can be seen at 48 and 72 hours. 
         FIG. 5F  is a plot showing GPC2 protein expression levels in CHLA90 neuroblastoma cells following transfection with GPC2 siRNA sequences 5 and 7 from Table 7 and a scrambled control siRNA. Protein expression was measured via flow cytometry of cells fixed and immunostained with a GPC2 antibody, and is reported as Mean Fluorescence (FL1) Intensity. Reduced GPC2 protein expression with siRNA sequences 5 and 7 can be seen at 72 hours. 
         FIG. 6  is as series of 12 images showing the effect of siRNA-mediated reduction in GPC2 expression on tumor spheroid formation. Columns, from left to right, show tumor spheroids from CHP212, SKNAS, SKNBE2 and CHLA90 neuroblastoma cells. At bottom, the percent knockdown efficiencies of GPC2 mRNA with the siRNA of sequence 5 from Table 1 are indicated. Top row: no treatment; middle row: cells transfected with a scrambled control siRNA; bottom row: cells were transfected with GPC2 siRNA of sequence 5 from Table 7. 
         FIG. 7A  is a series of four plots showing the relative levels of GPC2 mRNA following siRNA mediated GPC2 mRNA knockdown in established spheroid cultures. From left to right, spheroids from CHP212, SKNAS and SK—N-BE2 and CHLA90 neuroblastoma cells were transfected with either a scrambled siRNA control (siControl), or siRNAs of sequence 5 or sequence 7 from Table 7. 
         FIG. 7B  is a series of four plots showing the effect on cell viability of siRNA mediated GPC2 mRNA knockdown in established spheroid cultures. From left to right, spheroids from CHP212, SKNAS and SK—N-BE2 and CHLA90 neuroblastoma cells were transfected with either a scrambled siRNA control (siControl), or siRNAs of sequence 5 or sequence 7 from Table 7. 
     
    
    
     DETAILED DESCRIPTION 
     Glypican-2 (Glypican 2, GPC2, or GPC-2) is a cell surface protein that belongs to a family of six proteoglycans. These proteins are Glycosylphosphatidylinositol (GPI) anchored to the cell membrane, and play diverse roles in signaling and cancer cell growth. Although GPC2 was initially thought to be solely expressed during nervous system development, GPC2 is also expressed in neuroblastoma and other cancers. Further, GPC2 is regulated by the MYC oncogene via direct transcriptional activation. Treating GPC2 positive neuroblastoma cells with a GPC2 antibody conjugated to pyrrolobenzodiazepine, a cytotoxic DNA crosslinking agent, reduced cell proliferation and increased apoptosis in neuroblastoma cell lines and increased survival in neuroblast patient derived xenograft (PDX) mouse models. Higher levels of GPC2 expression can result in enhanced tumor cell growth, while decreasing GPC2 expression can decrease neuroblastoma cell viability. 
     Without wishing to be bound by theory, the inventors have found that use of a small interfering RNA (siRNA) can decrease GPC2 messenger RNA expression, in turn leading to a decrease in the degree of GPC-2 protein expression, and inhibiting proliferation of cancer cells expressing GPC2. Affecting GPC2 protein expression leads to a decrease in GPC2 function which results in an anti-cancer activity, for example by increasing apoptosis. 
     The inventors have shown that knocking down GPC2 mRNA resulted in a decrease in cell viability in multiple cancer cell lines. In addition, when combined with a chemotherapeutic agent, knocking down GPC2 mRNA resulted in a decrease in the IC 50  of the chemotherapeutic agent in treating cancer. Thus, knocking down GPC2 mRNA can enhance the activity of chemotherapeutic or therapeutic agents. When chemotherapeutic agents are administered in combination with GPC2 siRNAs, this combination can (a) reduce the therapeutically effective dose of the chemotherapeutic agent, (b) reduce side effects of the chemotherapeutic agent, and (c) increase the effectiveness of the chemotherapeutic agent. 
     In some embodiments, the siRNA targeting GPC2 is encapsulated in a nanoparticle that contains a tumor targeting agent or moiety. Exemplary tumor targeting agents include hyaluronic acid (HA). Tumor targeting agents on the surface of the nanoparticle can specifically target the nanoparticle to tumor cells that express a binding partner or receptor for the tumor targeting agent. For example, in the case of HA, HA on the nanoparticle can bind to CD44 molecules (CD44) on surface of cancer cells expressing CD44. Encapsulating GPC2 targeting siRNAs in a nanoparticle comprising a tumor targeting agent such as HA can thus increase the delivery of the siRNA to tumor cells. 
     GPC2 targeting siRNAs, and nanoparticles comprising same siRNAs, have utility for the treatment of any cancer that expresses GPC2. For example, neuroblastomas frequently express GPC2. GPC2 targeting siRNAs, and nanoparticles comprising siRNAs targeting GPC2, can be thus be used to treat neuroblastomas. 
     Accordingly, the disclosure provides nanoparticles comprising siRNAs, wherein the siRNA comprises a sense region and anti-sense region complementary to the sense region that together form an RNA duplex, and wherein the sense region comprises a sequence at least 70% to 100% identical to a glypican-2 (GPC2) mRNA sequence. 
     The disclosure provides pharmaceutical compositions comprising the nanoparticles comprising siRNAs targeting a GPC2 mRNA sequence described herein, and a pharmaceutically acceptable carrier, diluent or excipient. 
     The disclosure provides methods of treating a cancer in a subject, comprising administering to the subject a therapeutically effective amount of a composition comprising nanoparticles comprising siRNAs targeting a GPC2 mRNA described herein. In some embodiments, the methods further comprise combining the nanoparticles with a chemotherapeutic agent. 
     Definitions 
     “RNAi” or “RNA interference” refers to the process of sequence-specific post-transcriptional gene silencing, mediated by double-stranded RNA (dsRNA). Duplex RNA siRNA (small interfering RNA), miRNA (micro RNA), shRNA (short hairpin RNA), ddRNA (DNA-directed RNA), piRNA (Piwi-interacting RNA), or rasiRNA (repeat associated siRNA) and modified forms thereof are all capable of mediating RNA interference. These dsRNA molecules may be commercially available or may be designed and prepared based on known sequence information, etc. The anti-sense strand of these molecules can include RNA, DNA, PNA, or a combination thereof. These DNA/RNA chimera polynucleotide includes, but is not limited to, a double-strand polynucleotide composed of DNA and RNA that inhibits the expression of a target gene. These dsRNA molecules can also include one or more modified nucleotides, as described herein, which can be incorporated on either strand. 
     In the RNAi gene silencing or knockdown process, dsRNA comprising a first (anti-sense) strand that is complementary to a portion of a target gene and a second (sense) strand that is fully or partially complementary to the first anti-sense strand is introduced into an organism. After introduction into the organism, the target gene-specific dsRNA is processed into relatively small fragments (siRNAs) and can subsequently become distributed throughout the organism, decrease messenger RNA of target gene, leading to a phenotype that may come to closely resemble the phenotype arising from a complete or partial deletion of the target gene. 
     Certain dsRNAs in cells can undergo the action of Dicer enzyme, a ribonuclease III enzyme. Dicer can process the dsRNA into shorter pieces of dsRNA, i.e. siRNAs. RNAi also involves an endonuclease complex known as the RNA induced silencing complex (RISC). Following cleavage by Dicer, siRNAs enter the RISC complex and direct cleavage of a single stranded RNA target having a sequence complementary to the anti-sense strand of the siRNA duplex. The other strand of the siRNA is the passenger strand. Cleavage of the target RNA takes place in the middle of the region complementary to the anti-sense strand of the siRNA duplex. siRNAs can thus down regulate or knock down gene expression by mediating RNA interference in a sequence-specific manner. 
     As used herein, “target gene” or “target sequence” refers to a gene or gene sequence whose corresponding RNA is targeted for degradation through the RNAi pathway using dsRNAs or siRNAs as described herein. To target a gene, for example using an siRNA, the siRNA comprises an anti-sense region complementary to, or substantially complementary to, at least a portion of the target gene or sequence, and sense strand complementary to the anti-sense strand. Once introduced into a cell, the siRNA directs the RISC complex to cleave an RNA comprising a target sequence, thereby degrading the RNA. 
     As used herein, “nucleic acid,” “nucleotide sequence,” and “polynucleotide” are used interchangeably and encompass both RNA and DNA, including cDNA, genomic DNA, mRNA, synthetic (e.g., chemically synthesized) DNA or RNA and chimeras of RNA and DNA. The term polynucleotide, nucleotide sequence, or nucleic acid refers to a chain of nucleotides without regard to length of the chain. The nucleic acid can be double-stranded or single-stranded. Where single-stranded, the nucleic acid can be a sense strand or an anti-sense strand. The nucleic acid can be synthesized using oligonucleotide analogs or derivatives (e.g., inosine or phosphorothioate nucleotides). Such oligonucleotides can be used, for example, to prepare nucleic acids that have altered base-pairing abilities or increased resistance to nucleases. The present invention further provides a nucleic acid that is the complement (which can be either a full complement or a partial complement) of a nucleic acid, nucleotide sequence, or polynucleotide of this invention. When dsRNA is produced synthetically, less common bases, such as inosine, 5-methylcytosine, 6-methyladenine, hypoxanthine and others can also be used for anti-sense, dsRNA, and ribozyme pairing. Other modifications, such as modification to the phosphodiester backbone, or the 2′-hydroxy or 2′O-methyl in the ribose sugar group of the RNA can also be made. 
     The term “isolated” can refer to a nucleic acid, nucleotide sequence or polypeptide that is substantially free of cellular material, viral material, and/or culture medium (when produced by recombinant DNA techniques), or chemical precursors or other chemicals (when chemically synthesized). Moreover, an “isolated fragment” is a fragment of a nucleic acid, nucleotide sequence or polypeptide that is not naturally occurring as a fragment and would not be found in the natural state. “Isolated” does not mean that the preparation is technically pure (homogeneous), but it is sufficiently pure to provide the polypeptide or nucleic acid in a form in which it can be used for the intended purpose. 
     The term “fragment,” as applied to a polynucleotide, will be understood to mean a nucleotide sequence of reduced length relative to a reference nucleic acid or nucleotide sequence and comprising, consisting essentially of, and/or consisting of a nucleotide sequence of contiguous nucleotides identical or almost identical (e.g., 60%, 70%, 80%, 90%, 92%, 95%, 98% or 99% identical) to the reference nucleic acid or nucleotide sequence. Such a nucleic acid fragment according to the invention may be, where appropriate, included in a larger polynucleotide of which it is a constituent. In some embodiments, such fragments can comprise, consist essentially of, and/or consist of oligonucleotides having a length of at least about 8, 10, 12, 15, 20, 25, 30, 35, 40, 45, 50, 75, 100, 150, 200, or more consecutive nucleotides of a nucleic acid or nucleotide sequence according to the invention. 
     As used herein, “complementary” polynucleotides are those that are capable of base pairing according to the standard Watson-Crick complementarity rules. Specifically, purines will base pair with pyrimidines to form a combination of guanine paired with cytosine (G:C) and adenine paired with either thymine (A:T) in the case of DNA, or adenine paired with uracil (A:U) in the case of RNA. For example, the sequence “A-G-T” binds to the complementary sequence “T-C-A.” It is understood that two polynucleotides may hybridize to each other even if they are not completely complementary to each other, provided that each has at least one region that is substantially complementary to the other. 
     As used herein, the terms “substantially complementary” or “partially complementary” mean that two nucleic acid sequences are complementary at least at about 50%, 60%, 70%, 80% or 90% of their nucleotides. 
     In some embodiments, the two nucleic acid sequences can be complementary at least at 85%, 90%, 95%, 96%, 97%, 98%, 99% or more of their nucleotides. In some embodiments, the two nucleic acid sequences can be between 60% to 100% complementary, between 70% to 100% complementary, between 80% and 100% complementary, between 90% and 100% complementary, between 60% to 90% complementary, between 60% to 80% complementary, between 60% and 70% complementary, between 70% and 90% complementary, between 70% and 80% complementary, between 80% and 100% complementary, or between 80% and 90% complementary. 
     The terms “substantially complementary” and “partially complementary” can also mean that two nucleic acid sequences can hybridize under high stringency conditions, and such conditions are well known in the art. 
     As used herein, the term “identity” means that sequences are compared with one another as follows. In order to determine the percentage identity of two nucleic acid sequences, the sequences can first be aligned with respect to one another in order subsequently to make a comparison of these sequences possible. For this e.g. gaps can be inserted into the sequence of the first nucleic acid sequence and the nucleotides can be compared with the corresponding position of the second nucleic acid sequence. If a position in the first nucleic acid sequence is occupied by the same nucleotide as is the case at a position in the second sequence, the two sequences are identical at this position. The percentage identity between two sequences is a function of the number of identical positions divided by the number of all the positions compared in the sequences investigated. 
     A “percent identity” for aligned segments of a test sequence and a reference sequence is the percent of identical components which are shared by the two aligned sequences divided by the total number of components in reference sequence segment, i.e., the entire reference sequence or a smaller defined part of the reference sequence. 
     The percentage identity of two sequences can be determined with the aid of a mathematical algorithm. A preferred, but not limiting, example of a mathematical algorithm which can be used for comparison of two sequences is the algorithm of Karlin et al. (1993), PNAS USA, 90:5873-5877. Such an algorithm is integrated in the NBLAST program, with which sequences which have a desired identity to the sequences of the present invention can be identified. In order to obtain a gapped alignment, as described here, the “Gapped BLAST” program can be used, as is described in Altschul et al. (1997), Nucleic Acids Res, 25:3389-3402. If BLAST and Gapped BLAST programs are used, the preset parameters of the particular program (e.g. NBLAST) can be used. The sequences can be aligned further using version 9 of GAP (global alignment program) of the “Genetic Computing Group” using the preset (BLOSUM62) matrix (values −4 to +11) with a gap open penalty of −12 (for the first zero of a gap) and a gap extension penalty of −4 (for each additional successive zero in the gap). After the alignment, the percentage identity is calculated by expressing the number of agreements as a percentage content of the nucleic acids in the sequence claimed. The methods described for determination of the percentage identity of two nucleic acid sequences can also be used correspondingly, if necessary, on the coded amino acid sequences. 
     Useful methods for determining sequence identity are also disclosed in Guide to Huge Computers (Martin J. Bishop, ed., Academic Press, San Diego (1994)), and Carillo, H., and Lipton, D., (Applied Math 48:1073(1988)). More particularly, preferred computer programs for determining sequence identity include but are not limited to the Basic Local Alignment Search Tool (BLAST) programs which are publicly available from National Center Biotechnology Information (NCBI) at the National Library of Medicine, National Institute of Health, Bethesda, Md. 20894; see BLAST Manual, Altschul et al., NCBI, NLM, NIH; (Altschul et al., J. Mol. Biol. 215:403-410 (1990)); version 2.0 or higher of BLAST programs allows the introduction of gaps (deletions and insertions) into alignments; for peptide sequence BLASTX can be used to determine sequence identity; and, for polynucleotide sequence BLASTN can be used to determine sequence identity. Percent identity can be 70% identity or greater, e.g., at least 70% identity, at least 75% identity, at least 80% identity, at least 85% identity, at least 90% identity, at least 95% identity, at least 98% identity, at least 99% identity or 100% identity. 
     As used herein, “heterologous” refers to a nucleic acid sequence that either originates from another species or is from the same species or organism but is modified from either its original form or the form primarily expressed in the cell. Thus, a nucleotide sequence derived from an organism or species different from that of the cell into which the nucleotide sequence is introduced, is heterologous with respect to that cell and the cell&#39;s descendants. In addition, a heterologous nucleotide sequence includes a nucleotide sequence derived from and inserted into the same natural, original cell type, but which is present in a non-natural state, e.g., a different copy number, and/or under the control of different regulatory sequences than that found in nature. 
     Double Stranded RNAs Targeting Glypican-2 
     The disclosure provides double stranded RNAs (dsRNAs) which target a glypican-2 (GPC2) mRNA sequence for degradation. The double stranded RNA molecule of the invention may be in the form of any type of RNA interference molecule known in the art. In some embodiments, the double stranded RNA molecule is a small interfering RNA (siRNA). In other embodiments, the double stranded RNA molecule is a short hairpin RNA (shRNA) molecule. In other embodiments, the double stranded RNA molecule is a Dicer substrate that is processed in a cell to produce an siRNA. In other embodiments the double stranded RNA molecule is part of a microRNA precursor molecule. 
     In some embodiments, the dsRNA is a small interfering RNA (siRNA) which targets a glypican-2 (GPC2) mRNA sequence for degradation. In some embodiments, the siRNA targeting GPC2 is packaged in a nanoparticle. 
     An exemplary Glypican-2 sequence is described in NM_152742.3, the contents of which are incorporated by reference in their entirety herein. In some embodiments, a human GPC2 mRNA comprises a sequence of: 
     
       
         
           
               
               
            
               
                 (SEQ ID NO: 1) 
                   
               
            
           
           
               
               
               
            
               
                 1 
                 GCTCCCATTG TCTCGGCAGA TGCCGCCTGG TCCAGCTATC GTGCTCGGTA TTCAGTTTTC 
                   
               
            
           
           
               
               
            
               
                 ` 
                   
               
            
           
           
               
               
               
            
               
                 61 
                 CGGAGCAGCG CTCTTTCTCT GGCCCGCGGA GCGGTCCCGC GGCCGAGTAC CGGATTCCCG 
                   
               
               
                   
               
               
                 121 
                 AGTTTGGGAG GCTCTGCTTT CCTCCTTAGG ACCCACTTTG CCGTCCTGGG GTGGCTGCAG 
               
               
                   
               
               
                 181 
                 TTATGTCCGC GCTGCGACCT CTCCTGCTTC TGCTGCTGCC TCTGTGTCCC GGTCCTGGTC 
               
               
                   
               
               
                 241 
                 CCGGACCCGG GAGCGAGGCA AAGGTCACCC GGAGTTGTGC AGAGACCCGG CAGGTGCTGG 
               
               
                   
               
               
                 301 
                 GGGCCCGGGG ATATAGCTTA AACCTAATCC CTCCCGCCCT GATCTCAGGT GAGCACCTCC 
               
               
                   
               
               
                 361 
                 GGGTCTGTCC CCAGGAGTAC ACCTGCTGTT CCAGTGAGAC AGAGCAGAGG CTGATCAGGG 
               
               
                   
               
               
                 421 
                 AGACTGAGGC CACCTTCCGA GGCCTGGTGG AGGACAGCGG CTCCTTTCTG GTTCACACAC 
               
               
                   
               
               
                 481 
                 TGGCTGCCAG GCACAGAAAA TTTGATGAGT TTTTTCTGGA GATGCTCTCA GTAGCCCAGC 
               
               
                   
               
               
                 541 
                 ACTCTCTGAC CCAGCTCTTC TCCCACTCCT ACGGCCGCCT GTATGCCCAG CACGCCCTCA 
               
               
                   
               
               
                 601 
                 TATTCAATGG CCTGTTCTCT CGGCTGCGAG ACTTCTATGG GGAATCTGGT GAGGGGTTGG 
               
               
                   
               
               
                 661 
                 ATGACACCCT GGCGGATTTC TGGGCACAGC TCCTGGAGAG AGTGTTCCCG CTGCTGCACC 
               
               
                   
               
               
                 721 
                 CACAGTACAG CTTCCCCCCT GACTACCTGC TCTGCCTCTC ACGCTTGGCC TCATCTACCG 
               
               
                   
               
               
                 781 
                 ATGGCTCTCT GCAGCCCTTT GGGGACTCAC CCCGCCGCCT CCGCCTGCAG ATAACCCGGA 
               
               
                   
               
               
                 841 
                 CCCTGGTGGC TGCCCGAGCC TTTGTGCAGG GCCTGGAGAC TGGAAGAAAT GTGGTCAGCG 
               
               
                   
               
               
                 901 
                 AAGCGCTTAA GGTGCCGGTG TCTGAAGGCT GCAGCCAGGC TCTGATGCGT CTCATCGGCT 
               
               
                   
               
               
                 961 
                 GTCCCCTGTG CCGGGGGGTC CCCTCACTTA TGCCCTGCCA GGGCTTCTGC CTCAACGTGG 
               
               
                   
               
               
                 1021 
                 TTCGTGGCTG TCTCAGCAGC AGGGGACTGG AGCCTGACTG GGGCAACTAT CTGGATGGTC 
               
               
                   
               
               
                 1081 
                 TCCTGATCCT GGCTGATAAG CTCCAGGGCC CCTTTTCCTT TGAGCTGACG GCCGAGTCCA 
               
               
                   
               
               
                 1141 
                 TTGGGGTGAA GATCTCGGAG GGTTTGATGT ACCTGCAGGA AAACAGTGCG AAGGTGTCCG 
               
               
                   
               
               
                 1201 
                 CCCAGGTGTT TCAGGAGTGC GGCCCCCCCG ACCCGGTGCC TGCCCGCAAC CGTCGAGCCC 
               
               
                   
               
               
                 1261 
                 CGCCGCCCCG GGAAGAGGCG GGCCGGCTGT GGTCGATGGT GACCGAGGAG GAGCGGCCCA 
               
               
                   
               
               
                 1321 
                 CGACGGCCGC AGGCACCAAC CTGCACCGGC TGGTGTGGGA GCTCCGCGAG CGTCTGGCCC 
               
               
                   
               
               
                 1381 
                 GGATGCGGGG CTTCTGGGCC CGGCTGTCCC TGACGGTGTG CGGAGACTCT CGCATGGCAG 
               
               
                   
               
               
                 1441 
                 CGGACGCCTC GCTGGAGGCG GCGCCCTGCT GGACCGGAGC CGGGCGGGGC CGGTACTTGC 
               
               
                   
               
               
                 1501 
                 CGCCAGTGGT CGGGGGCTCC CCGGCCGAGC AGGTCAACAA CCCCGAGCTC AAGGTGGACG 
               
               
                   
               
               
                 1561 
                 CCTCGGGCCC CGATGTCCCG ACACGGCGGC GTCGGCTACA GCTCCGGGCG GCCACGGCCA 
               
               
                   
               
               
                 1621 
                 GAATGAAAAC GGCCGCACTG GGACACGACC TGGACGGGCA GGACGCGGAT GAGGATGCCA 
               
               
                   
               
               
                 1681 
                 GCGGCTCTGG AGGGGGACAG CAGTATGCAG ATGACTGGAT GGCTGGGGCT GTGGCTCCCC 
               
               
                   
               
               
                 1741 
                 CAGCCCGGCC TCCTCGGCCT CCATACCCTC CTAGAAGGGA TGGTTCTGGG GGCAAAGGAG 
               
               
                   
               
               
                 1801 
                 GAGGTGGCAG TGCCCGCTAC AACCAGGGCC GGAGCAGGAG TGGGGGGGCA TCTATTGGTT 
               
               
                   
               
               
                 1861 
                 TTCACACCCA AACCATCCTC ATTCTCTCCC TCTCAGCCCT GGCCCTGCTT GGACCTCGAT 
               
               
                   
               
               
                 1921 
                 AACGGGGGAG GGGTGCCCTA GCATCAGAAG GGTTCATGGC CCTTTCCCCT CCTCCCCCCT 
               
               
                   
               
               
                 1981 
                 CAGCTGGGCC TGGGGAGGAG TCGAAGGGGG CTGCAGAGAG GGTAGAGAAG GGACTTTGCA 
               
               
                   
               
               
                 2041 
                 GGTGAATGGC TGGGGCCCCA AATCCAGGAG ATTTTCATCA GAGGTGGGTG GGTGTTCACA 
               
               
                   
               
               
                 2101 
                 ATATTTATTT TTTCATTTGG TAATGGGAGG GGGGCCTGGG GGTATTTATT TAGGAGGGAG 
               
               
                   
               
               
                 2161 
                 TGTGGTTTCC TTAGAAGGTA TAGTCTCTAG CCCTCTAAGG CTGGGGCTGG TGATCAGCCC 
               
               
                   
               
               
                 2221 
                 CAACAGAGAA AATGAGGAGT TTAGAGTTGC AGCTGGGGAA GGGGTTTGAA GGAAGTTGGA 
               
               
                   
               
               
                 2281 
                 AGTGGGGAGG GGTGGGGGCA TCTGGTCTCA GAAATGGACC AGCTGGATGC AGGGCAGGGG 
               
               
                   
               
               
                 2341 
                 ACTGAGGGTG CTTGAGTAGG ATGTGAGACT TCATGGGCCT GGGTTCTGTT GAGTTTTTTC 
               
               
                   
               
               
                 2401 
                 AGTATCAATT TCTTAAACCA AATTTTAAAA AAAACAAGGT GGGGGGGTGC TCATCTCGTG 
               
               
                   
               
               
                 2461 
                 ACCTCTGCCA CCCACATCCT TCACAAACTC CATGTTTCAG TGTTTGAGTC CATGTTTATT 
               
               
                   
               
               
                 2521 
                 CTGCAAATAA ATGGTAATGT ATTGGA. 
               
            
           
         
       
     
     A further example of a Glypican-2 sequence is described in NM_152742.2, the contents of which are incorporated by reference in their entirety herein. In some embodiments, a human GPC2 mRNA comprises a sequence of: 
     
       
         
           
               
               
            
               
                 (SEQ ID NO: 2) 
                   
               
            
           
           
               
               
               
            
               
                 1 
                 ATTGGCGGGG CCCCGCCTCG GGCCCCGCCC CCTGTCCGGC TCCCCGCTCC CATTGTCTCG 
                   
               
               
                   
               
               
                 61 
                 GCAGATGCCG CCTGGTCCAG CTATCGTGCT CGGTATTCAG TTTTCCGGAG CAGCGCTCTT 
               
               
                   
               
               
                 121 
                 TCTCTGGCCC GCGGAGCGGT CCCGCGGCCG AGTACCGGAT TCCCGAGTTT GGGAGGCTCT 
               
               
                   
               
               
                 181 
                 GCTTTCCTCC TTAGGACCCA CTTTGCCGTC CTGGGGTGGC TGCAGTTATG TCCGCGCTGC 
               
               
                   
               
               
                 241 
                 GACCTCTCCT GCTTCTGCTG CTGCCTCTGT GTCCCGGTCC TGGTCCCGGA CCCGGGAGCG 
               
               
                   
               
               
                 301 
                 AGGCAAAGGT CACCCGGAGT TGTGCAGAGA CCCGGCAGGT GCTGGGGGCC CGGGGATATA 
               
               
                   
               
               
                 361 
                 GCTTAAACCT AATCCCTCCC GCCCTGATCT CAGGTGAGCA CCTCCGGGTC TGTCCCCAGG 
               
               
                   
               
               
                 421 
                 AGTACACCTG CTGTTCCAGT GAGACAGAGC AGAGGCTGAT CAGGGAGACT GAGGCCACCT 
               
               
                   
               
               
                 481 
                 TCCGAGGCCT GGTGGAGGAC AGCGGCTCCT TTCTGGTTCA CACACTGGCT GCCAGGCACA 
               
               
                   
               
               
                 541 
                 GAAAATTTGA TGAGTTTTTT CTGGAGATGC TCTCAGTAGC CCAGCACTCT CTGACCCAGC 
               
               
                   
               
               
                 601 
                 TCTTCTCCCA CTCCTACGGC CGCCTGTATG CCCAGCACGC CCTCATATTC AATGGCCTGT 
               
               
                   
               
               
                 661 
                 TCTCTCGGCT GCGAGACTTC TATGGGGAAT CTGGTGAGGG GTTGGATGAC ACCCTGGCGG 
               
               
                   
               
               
                 721 
                 ATTTCTGGGC ACAGCTCCTG GAGAGAGTGT TCCCGCTGCT GCACCCACAG TACAGCTTCC 
               
               
                   
               
               
                 781 
                 CCCCTGACTA CCTGCTCTGC CTCTCACGCT TGGCCTCATC TACCGATGGC TCTCTGCAGC 
               
               
                   
               
               
                 841 
                 CCTTTGGGGA CTCACCCCGC CGCCTCCGCC TGCAGATAAC CCGGACCCTG GTGGCTGCCC 
               
               
                   
               
               
                 901 
                 GAGCCTTTGT GCAGGGCCTG GAGACTGGAA GAAATGTGGT CAGCGAAGCG CTTAAGGTGC 
               
               
                   
               
               
                 961 
                 CGGTGTCTGA AGGCTGCAGC CAGGCTCTGA TGCGTCTCAT CGGCTGTCCC CTGTGCCGGG 
               
               
                   
               
               
                 1021 
                 GGGTCCCCTC ACTTATGCCC TGCCAGGGCT TCTGCCTCAA CGTGGTTCGT GGCTGTCTCA 
               
               
                   
               
               
                 1081 
                 GCAGCAGGGG ACTGGAGCCT GACTGGGGCA ACTATCTGGA TGGTCTCCTG ATCCTGGCTG 
               
               
                   
               
               
                 1141 
                 ATAAGCTCCA GGGCCCCTTT TCCTTTGAGC TGACGGCCGA GTCCATTGGG GTGAAGATCT 
               
               
                   
               
               
                 1201 
                 CGGAGGGTTT GATGTACCTG CAGGAAAACA GTGCGAAGGT GTCCGCCCAG GTGTTTCAGG 
               
               
                   
               
               
                 1261 
                 AGTGCGGCCC CCCCGACCCG GTGCCTGCCC GCAACCGTCG AGCCCCGCCG CCCCGGGAAG 
               
               
                   
               
               
                 1321 
                 AGGCGGGCCG GCTGTGGTCG ATGGTGACCG AGGAGGAGCG GCCCACGACG GCCGCAGGCA 
               
               
                   
               
               
                 1381 
                 CCAACCTGCA CCGGCTGGTG TGGGAGCTCC GCGAGCGTCT GGCCCGGATG CGGGGCTTCT 
               
               
                   
               
               
                 1441 
                 GGGCCCGGCT GTCCCTGACG GTGTGCGGAG ACTCTCGCAT GGCAGCGGAC GCCTCGCTGG 
               
               
                   
               
               
                 1501 
                 AGGCGGCGCC CTGCTGGACC GGAGCCGGGC GGGGCCGGTA CTTGCCGCCA GTGGTCGGGG 
               
               
                   
               
               
                 1561 
                 GCTCCCCGGC CGAGCAGGTC AACAACCCCG AGCTCAAGGT GGACGCCTCG GGCCCCGATG 
               
               
                   
               
               
                 1621 
                 TCCCGACACG GCGGCGTCGG CTACAGCTCC GGGCGGCCAC GGCCAGAATG AAAACGGCCG 
               
               
                   
               
               
                 1681 
                 CACTGGGACA CGACCTGGAC GGGCAGGACG CGGATGAGGA TGCCAGCGGC TCTGGAGGGG 
               
               
                   
               
               
                 1741 
                 GACAGCAGTA TGCAGATGAC TGGATGGCTG GGGCTGTGGC TCCCCCAGCC CGGCCTCCTC 
               
               
                   
               
               
                 1801 
                 GGCCTCCATA CCCTCCTAGA AGGGATGGTT CTGGGGGCAA AGGAGGAGGT GGCAGTGCCC 
               
               
                   
               
               
                 1861 
                 GCTACAACCA GGGCCGGAGC AGGAGTGGGG GGGCATCTAT TGGTTTTCAC ACCCAAACCA 
               
               
                   
               
               
                 1921 
                 TCCTCATTCT CTCCCTCTCA GCCCTGGCCC TGCTTGGACC TCGATAACGG GGGAGGGGTG 
               
               
                   
               
               
                 1981 
                 CCCTAGCATC AGAAGGGTTC ATGGCCCTTT CCCCTCCTCC CCCCTCAGCT GGGCCTGGGG 
               
               
                   
               
               
                 2041 
                 AGGAGTCGAA GGGGGCTGCA GAGAGGGTAG AGAAGGGACT TTGCAGGTGA ATGGCTGGGG 
               
               
                   
               
               
                 2101 
                 CCCCAAATCC AGGAGATTTT CATCAGAGGT GGGTGGGTGT TCACAATATT TATTTTTTCA 
               
               
                   
               
               
                 2161 
                 TTTGGTAATG GGAGGGGGGC CTGGGGGTAT TTATTTAGGA GGGAGTGTGG TTTCCTTAGA 
               
               
                   
               
               
                 2221 
                 AGGTATAGTC TCTAGCCCTC TAAGGCTGGG GCTGGTGATC AGCCCCAACA GAGAAAATGA 
               
               
                   
               
               
                 2281 
                 GGAGTTTAGA GTTGCAGCTG GGGAAGGGGT TTGAAGGAAG TTGGAAGTGG GGAGGGGTGG 
               
               
                   
               
               
                 2341 
                 GGGCATCTGG TCTCAGAAAT GGACCAGCTG GATGCAGGGC AGGGGACTGA GGGTGCTTGA 
               
               
                   
               
               
                 2401 
                 GTAGGATGTG AGACTTCATG GGCCTGGGTT CTGTTGAGTT TTTTCAGTAT CAATTTCTTA 
               
               
                   
               
               
                 2461 
                 AACCAAATTT TAAAAAAAAC AAGGTGGGGG GGTGCTCATC TCGTGACCTC TGCCACCCAC 
               
               
                   
               
               
                 2521 
                 ATCCTTCACA AACTCCATGT TTCAGTGTTT GAGTCCATGT TTATTCTGCA AATAAATGGT 
               
               
                   
               
               
                 2581 
                 AATGTATTGG AAAAAAAAAA AAAAAAAAAA AAAAA. 
               
            
           
         
       
     
     siRNAs targeting GPC2 for degradation can comprise a sense strand at least 70% identical to any fragment of a GPC2 mRNA, for example the GPC2 mRNA of SEQ ID NO: 1 or SEQ ID NO: 2. In some embodiments, the sense strand comprises or consists essentially of a sequence at least 70%, at least 80%, at least 90%, at least 95% or is 100% identical to any fragment of SEQ ID NO: 1 or SEQ ID NO: 2. siRNAs targeting GPC2 for degradation can comprise an anti-sense strand at least 70% identical to a sequence complementary to any fragment of a GPC2 mRNA, for example the GPC2 mRNA of SEQ ID NO: 1 or SEQ ID NO: 2. In some embodiments, the anti-sense strand comprises or consists essentially of a sequence at least 70%, at least 80%, at least 90%, at least 95% or is 100% identical to a sequence complementary to any fragment of SEQ ID NO: 1 or SEQ ID NO: 2. In some embodiments, the sense region and anti-sense regions are complementary, and basepair to form an RNA duplex structure. The fragment of the GPC2 mRNA that has percent identity to the sense region of the siRNA, and which is complementary to the anti-sense region of the siRNA, can be protein coding sequence of the mRNA, an untranslated region (UTR) of the mRNA (5′ UTR or 3′ UTR), or both. 
     In some embodiments, the siRNA comprises a sense region and anti-sense region complementary to the sense region that together form an RNA duplex, and the sense region comprises a sequence at least 70% identical to a glypican-2 (GPC2) mRNA sequence. In some embodiments, the sense region is identical to a GPC2 mRNA sequence. 
     As used herein, the term “sense strand” or “sense region” refers to a nucleotide sequence of an siRNA molecule that is partially or fully complementary to at least a portion of a corresponding anti-sense strand or anti-sense region of the siRNA molecule. The sense strand of an siRNA molecule can include a nucleic acid sequence having some percentage identity with a target nucleic acid sequence such as a GPC2 mRNA sequence. In some cases, the sense region may have 100% identity, i.e. complete identity or homology, to the target nucleic acid sequence. In other cases, there may be one or more mismatches between the sense region and the target nucleic acid sequence. For example, there may be 1, 2, 3, 4, 5, 6, or 7 mismatches between the sense region and the target nucleic acid sequence. 
     As used herein, the term “anti-sense strand” or “anti-sense region” refers to a nucleotide sequence of an siRNA molecule that is partially or fully complementary to at least a portion of a target nucleic acid sequence. The anti-sense strand of an siRNA molecule can include a nucleic acid sequence that is complementary to at least a portion of a corresponding sense strand of the siRNA molecule. 
     In some embodiments, the sense region comprises a sequence that is at least 70% identical, at least 75% identical, at least 80% identical, at least 85% identical, at least 90% identical, at least 95% identical, at least 97% identical or 100% identical to a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. In some embodiments, the sense region consists essentially of a sequence that is at least 70% identical, at least 75% identical, at least 80% identical, at least 85% identical, at least 90% identical, at least 95% identical, at least 97% identical or 100% identical to a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. In some embodiments, the sense region comprises a sequence that is identical to a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. In some embodiments, the sense region consists essentially of a sequence that is identical to a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. 
     In some embodiments, the sense region of the siRNA targeting GPC2 has one or more mismatches between the sequence of the siRNA and the GPC2 sequence. For example, the sequence of the sense region may have 1, 2, 3, 4 or 5 mismatches between the sequence of the sense region of the siRNA and the GPC2 sequence. In some embodiments, the GPC2 sequence is a GPC2 3′ untranslated region sequence (3′ UTR). Without wishing to be bound by theory, it is thought that siRNAs targeting the 3′ UTR have elevated mismatch tolerance when compared to mismatches in siRNAs targeting coding regions of a gene. Further, siRNAs may be tolerant of mismatches outside the siRNA seed region. As used herein, the “seed region” of the siRNA refers to base pairs 2-8 of the anti-sense region of the siRNA, i.e. the strand of the siRNA that is complementary to and hybridizes to the target mRNA. 
     In some embodiments, the anti-sense region comprises a sequence that is at least 70% identical, at least 75% identical, at least 80% identical, at least 85% identical, at least 90% identical, at least 95% identical, at least 97% identical or 100% identical to a sequence complementary to a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. In some embodiments, the anti-sense region consists essentially of a sequence that is at least 70% identical, at least 75% identical, at least 80% identical, at least 85% identical, at least 90% identical, at least 95% identical, at least 97% identical or 100% identical to a sequence complementary to a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. In some embodiments, the anti-sense region comprises a sequence that is identical to a sequence complementary to a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. In some embodiments, the sense region consists essentially of a sequence that is complementary to a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. 
     The anti-sense region of the GPC2 targeting siRNA is complementary to the sense region. In some embodiments, the sense region and the anti-sense region are fully complementary (no mismatches). In some embodiments the anti-sense region is partially complementary to the sense region, i.e., there are 1, 2, 3, 4 or 5 mismatches between the sense region and the anti-sense region. 
     In general, siRNAs comprise an RNA duplex that is about 16 to about 25 nucleotides in length. In some embodiments, the RNA duplex is between 17 and 24 nucleotides in length, between about 18 and 23 nucleotides in length, or between about 19 and 22 nucleotides in length. In some embodiments, the RNA duplex is 19 nucleotides in length. 
     In some embodiments, the sense region is encoded by a first single stranded RNA molecule, and the anti-sense region is encoded by a second single stranded RNA molecule. In some embodiments, the siRNA targeting GPC2 comprises two different single stranded RNAs, the first comprising the sense region and the second comprising the anti-sense region, which hybridize to form an RNA duplex. 
     siRNAs of the disclosure can have one or more overhangs from the duplex region. The overhangs, which are non-base-paired, single strand regions, can be from one to eight nucleotides in length, or longer. An overhang can be a 3′ overhang, wherein the 3′-end of a strand has a single strand region of from one to eight nucleotides. An overhang can be a 5′ overhang, wherein the 5′-end of a strand has a single strand region of from one to eight nucleotides. 
     The overhangs of the siRNAs can be the same length, or can be different lengths. 
     siRNAs can have one or more blunt ends, in which the duplex region ends with no overhang, and the strands are base paired to the end of the duplex region. siRNAs of the disclosure can have one or more blunt ends, or can have one or more overhangs, or can have a combination of a blunt end and an overhang end. For example, the 5′ end of the siRNA can be blunt and the 3′ end of the same siRNA comprise an overhang, or vice versa. 
     In some embodiments, both ends of the siRNA are blunt ends. 
     In additional embodiments, both ends of siRNA have an overhang. In some embodiments, the overhang is a 3′ overhang, for example a 3′ dinucleotide overhang on each end. The overhangs at the 5′- and 3′-ends may be of different lengths, or be the same length. 
     An overhang of an siRNA can contain one or more deoxyribonucleotides, one or more ribonucleotides, or a combination of deoxyribonucleotides and ribonucleotides. In some embodiments, one, or both, of the overhang nucleotides of an siRNA may be 2′-deoxyribonucleotides. 
     In some embodiments, the first single stranded RNA molecule comprises a first 3′ overhang. In some embodiments, the second single stranded RNA molecule comprises a second 3′ overhang. In some embodiments, the first and second 3′ overhangs comprise a dinucleotide. In some embodiments, the dinucleotide comprises thymidine-thymidine (dT-dT) or Uracil-Uracil (UU). Without wishing to be bound by theory, it is thought that 3′ overhangs, such as dinucleotide overhangs, enhance siRNA mediated mRNA degradation by enhancing siRNA-RISC complex formation, and/or rate of cleavage of the target mRNA by the siRNA-RISC complex. 
     In some embodiments, the sense region comprises a sequence selected from the group listed in Table 1 and Table 2. In some embodiments, the anti-sense region comprises a sequence selected from the group listed in Table 1 or Table 2. In some embodiments, the sense and anti-sense regions comprise complementary sequences selected from the group listed in Table 1 and Table 2. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Sense and anti-sense regions of 
               
               
                 representative GPC2 siRNAs 
               
            
           
           
               
               
               
            
               
                   
                 Sense Region 
                 Anti-sense Region 
               
               
                   
                   
               
               
                   
                 CUCCUGAUCCUGGCUGAUA 
                 UAUCAGCCAGGAUCAGGAG 
               
               
                   
                 (SEQ ID NO: 9) 
                 (SEQ ID NO: 10) 
               
               
                   
                   
               
               
                   
                 CUCAUCUACCGAUGGCUCU 
                 AGAGCCAUCGGUAGAUGAG 
               
               
                   
                 (SEQ ID NO: 11) 
                 (SEQ ID NO: 12) 
               
               
                   
                   
               
               
                   
                 CCUGCUUGGACCUCGAUAA 
                 UUAUCGAGGUCCAAGCAGG 
               
               
                   
                 (SEQ ID NO: 3) 
                 (SEQ ID NO: 6) 
               
               
                   
                   
               
               
                   
                 GUGGUUCGUGGCUGUCUCA 
                 UGAGACAGCCACGAACCAC 
               
               
                   
                 (SEQ ID NO: 13) 
                 (SEQ ID NO: 14) 
               
               
                   
                   
               
               
                   
                 CUCAGUAGCCCAGCACUCU 
                 AGAGUGCUGGGCUACUGAG 
               
               
                   
                 (SEQ ID NO: 4) 
                 (SEQ ID NO: 7) 
               
               
                   
                   
               
               
                   
                 CUGCUGUUCCAGUGAGACA 
                 UGUCUCACUGGAACAGCAG 
               
               
                   
                 (SEQ ID NO: 15) 
                 (SEQ ID NO: 16) 
               
               
                   
                   
               
               
                   
                 CUCCUUUCUGGUUCACACA 
                 UGUGUGAACCAGAAAGGAG 
               
               
                   
                 (SEQ ID NO: 5) 
                 (SEQ ID NO: 8) 
               
               
                   
                   
               
               
                   
                 GAGUGUGGUUUCCUUAGAA 
                 UUCUAAGGAAACCACACUC 
               
               
                   
                 (SEQ ID NO: 17) 
                 (SEQ ID NO: 18) 
               
               
                   
                   
               
               
                   
                 GAGUACACCUGCUGUUCCA 
                 UGGAACAGCAGGUGUACUC 
               
               
                   
                 (SEQ ID NO: 19) 
                 (SEQ ID NO: 20) 
               
               
                   
                   
               
               
                   
                 GACACGACCUGGACGGGCA 
                 UGCCCGUCCAGGUCGUGUC 
               
               
                   
                 (SEQ ID NO: 21) 
                 (SEQ ID NO: 22) 
               
               
                   
                   
               
               
                   
                 CUGACUACCUGCUCUGCCU 
                 AGGCAGAGCAGGUAGUCAG 
               
               
                   
                 (SEQ ID NO: 23) 
                 (SEQ ID NO: 24) 
               
               
                   
                   
               
               
                   
                 GCGCUUAAGGUGCCGGUGU 
                 ACACCGGCACCUUAAGCGC 
               
               
                   
                 (SEQ ID NO: 25) 
                 (SEQ ID NO: 26) 
               
               
                   
                   
               
               
                   
                 CCUUUGAGCUGACGGCCGA 
                 UCGGCCGUCAGCUCAAAGG 
               
               
                   
                 (SEQ ID NO: 27) 
                 (SEQ ID NO: 28) 
               
               
                   
                   
               
               
                   
                 CCUGCUUCUGCUGCUGCCU 
                 AGGCAGCAGCAGAAGCAGG 
               
               
                   
                 (SEQ ID NO: 29) 
                 (SEQ ID NO: 30) 
               
               
                   
                   
               
               
                   
                 GAAGAAAUGUGGUCAGCGA 
                 UCGCUGACCACAUUUCUUC 
               
               
                   
                 (SEQ ID NO: 31) 
                 (SEQ ID NO: 32) 
               
               
                   
                   
               
            
           
         
       
     
     In some embodiments, the sense region comprises a sequence of CCUGCUUGGACCUCGAUAA (SEQ ID NO: 3), CUCAGUAGCCCAGCACUCU (SEQ ID NO: 4) or CUCCUUUCUGGUUCACACA (SEQ ID NO: 5). In some embodiments, the anti-sense region comprises a sequence complementary to the sense region. 
     In some embodiments, the sense region comprises a sequence of CUCCUGAUCCUGGCUGAUA (SEQ ID NO: 9) and the anti-sense region comprises a sequence of UAUCAGCCAGGAUCAGGAG (SEQ ID NO: 10). 
     In some embodiments, the sense region comprises a sequence of CUCAUCUACCGAUGGCUCU (SEQ ID NO: 11) and the anti-sense region comprises a sequence of AGAGCCAUCGGUAGAUGAG (SEQ ID NO: 12). 
     In some embodiments, the sense region comprises a sequence of GUGGUUCGUGGCUGUCUCA (SEQ ID NO: 13) and the anti-sense region comprises a sequence of UGAGACAGCCACGAACCAC (SEQ ID NO: 14). 
     In some embodiments, the sense region comprises a sequence of CUGCUGUUCCAGUGAGACA (SEQ ID NO: 15) and the anti-sense region comprises a sequence of UGUCUCACUGGAACAGCAG (SEQ ID NO: 16). 
     In some embodiments, the sense region comprises a sequence of GAGUGUGGUUUCCUUAGAA (SEQ ID NO: 17) and the anti-sense region comprises a sequence of UUCUAAGGAAACCACACUC (SEQ ID NO: 18). 
     In some embodiments, the sense region comprises a sequence of GAGUACACCUGCUGUUCCA (SEQ ID NO: 19) and the anti-sense region comprises a sequence of UGGAACAGCAGGUGUACUC (SEQ ID NO: 20). 
     In some embodiments, the sense region comprises a sequence of GACACGACCUGGACGGGCA (SEQ ID NO: 21) and the anti-sense region comprises a sequence of UGCCCGUCCAGGUCGUGUC (SEQ ID NO: 22). 
     In some embodiments, the sense region comprises a sequence of CUGACUACCUGCUCUGCCU (SEQ ID NO: 23) and the anti-sense region comprises a sequence of AGGCAGAGCAGGUAGUCAG (SEQ ID NO: 24). 
     In some embodiments, the sense region comprises a sequence of GCGCUUAAGGUGCCGGUGU (SEQ ID NO: 25) and the anti-sense region comprises a sequence of ACACCGGCACCUUAAGCGC (SEQ ID NO: 26). 
     In some embodiments, the sense region comprises a sequence of CCUUUGAGCUGACGGCCGA (SEQ ID NO: 27) and the anti-sense region comprises a sequence of UCGGCCGUCAGCUCAAAGG (SEQ ID NO: 28). 
     In some embodiments, the sense region comprises a sequence of CCUGCUUCUGCUGCUGCCU (SEQ ID NO: 29) and the anti-sense region comprises a sequence of AGGCAGCAGCAGAAGCAGG (SEQ ID NO: 30). 
     In some embodiments, the sense region comprises a sequence of GAAGAAAUGUGGUCAGCGA (SEQ ID NO: 31) and the anti-sense region comprises a sequence of UCGCUGACCACAUUUCUUC (SEQ ID NO: 32). 
     In some embodiments, the sense region comprises a sequence of CCUGCUUGGACCUCGAUAA (SEQ ID NO: 3) and the anti-sense region comprises a sequence of UUAUCGAGGUCCAAGCAGG (SEQ ID NO: 6). 
     In some embodiments, the sense region comprises a sequence of CUCAGUAGCCCAGCACUCU (SEQ ID NO: 4) and the anti-sense region comprises a sequence of AGAGUGCUGGGCUACUGAG (SEQ ID NO: 7). 
     In some embodiments, the sense region comprises a sequence of CUCCUUUCUGGUUCACACA (SEQ ID NO: 5) and the anti-sense region comprises a sequence of UGUGUGAACCAGAAAGGAG (SEQ ID NO: 8). 
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Sense and anti-sense regions of 
               
               
                 representative GPC2 siRNAs 
               
            
           
           
               
               
            
               
                 Sense Region 
                 Anti-sense Region 
               
               
                   
               
               
                 GGCUCCUUUCUGGUUCACA 
                 UGUGAACCAGAAAGGAGCC 
               
               
                 (SEQ ID NO: 33) 
                 (SEQ ID NO: 34) 
               
               
                   
               
               
                 GCCUGGAGACUGGAAGAAA 
                 UUUCUUCCAGUCUCCAGGC 
               
               
                 (SEQ ID NO: 35) 
                 (SEQ ID NO: 36) 
               
               
                   
               
               
                 GCAACUAUCUGGAUGGUCU 
                 AGACCAUCCAGAUAGUUGC 
               
               
                 (SEQ ID NO: 37) 
                 (SEQ ID NO: 38) 
               
               
                   
               
               
                 GACUGAGGGUGCUUGAGUA 
                 UACUCAAGCACCCUCAGUC 
               
               
                 (SEQ ID NO: 39) 
                 (SEQ ID NO: 40) 
               
               
                   
               
               
                 GUGCUUGAGUAGGAUGUGA 
                 UCACAUCCUACUCAAGCAC 
               
               
                 (SEQ ID NO: 41) 
                 (SEQ ID NO: 42) 
               
               
                   
               
               
                 GCUUGAGUAGGAUGUGAGA 
                 UCUCACAUCCUACUCAAGC 
               
               
                 (SEQ ID NO: 43) 
                 (SEQ ID NO: 44) 
               
               
                   
               
               
                 GUAGGAUGUGAGACUUCAU 
                 AUGAAGUCUCACAUCCUAC 
               
               
                 (SEQ ID NO: 45) 
                 (SEQ ID NO: 46) 
               
               
                   
               
               
                 CCUCCUUAGGACCCACUUU 
                 AAAGUGGGUCCUAAGGAGG 
               
               
                 (SEQ ID NO: 47) 
                 (SEQ ID NO: 48) 
               
               
                   
               
               
                 GCUGCGACCUCUCCUGCUU 
                 AAGCAGGAGAGGUCGCAGC 
               
               
                 (SEQ ID NO: 49) 
                 (SEQ ID NO: 50) 
               
               
                   
               
               
                 GCACGCCCUCAUAUUCAAU 
                 AUUGAAUAUGAGGGCGUGC 
               
               
                 (SEQ ID NO: 51) 
                 (SEQ ID NO: 52) 
               
               
                   
               
               
                 GGAUGACACCCUGGCGGAU 
                 AUCCGCCAGGGUGUCAUCC 
               
               
                 (SEQ ID NO: 53) 
                 (SEQ ID NO: 54) 
               
               
                   
               
               
                 CCUGGAGACUGGAAGAAAU 
                 AUUUCUUCCAGUCUCCAGG 
               
               
                 (SEQ ID NO: 55) 
                 (SEQ ID NO: 56) 
               
               
                   
               
               
                 GCCAGGGCUUCUGCCUCAA 
                 UUGAGGCAGAAGCCCUGGC 
               
               
                 (SEQ ID NO: 57) 
                 (SEQ ID NO: 58) 
               
               
                   
               
               
                 GCUGACGGCCGAGUCCAUU 
                 AAUGGACUCGGCCGUCAGC 
               
               
                 (SEQ ID NO: 59) 
                 (SEQ ID NO: 60) 
               
               
                   
               
               
                 CCCUAGCAUCAGAAGGGUU 
                 AACCCUUCUGAUGCUAGGG 
               
               
                 (SEQ ID NO: 61) 
                 (SEQ ID NO: 62) 
               
               
                   
               
               
                 CCACCCACAUCCUUCACAA 
                 UUGUGAAGGAUGUGGGUGG 
               
               
                 (SEQ ID NO: 63) 
                 (SEQ ID NO: 64) 
               
               
                   
               
               
                 CCAUGUUUAUUCUGCAAAU 
                 AUUUGCAGAAUAAACAUGG 
               
               
                 (SEQ ID NO: 65) 
                 (SEQ ID NO: 66) 
               
               
                   
               
               
                 GCUAUCGUGCUCGGUAUUCA 
                 UGAAUACCGAGCACGAUAGC 
               
               
                 (SEQ ID NO: 67) 
                 (SEQ ID NO: 68) 
               
               
                   
               
               
                 AUCGUGCUCGGUAUUCAGUU 
                 AACUGAAUACCGAGCACGAU 
               
               
                 (SEQ ID NO: 69) 
                 (SEQ ID NO: 70) 
               
               
                   
               
               
                 GCUCUGCUUUCCUCCUUAGG 
                 CCUAAGGAGGAAAGCAGAGC 
               
               
                 (SEQ ID NO: 71) 
                 (SEQ ID NO: 72) 
               
               
                   
               
               
                 GCUUCUGCUGCUGCCUCUGU 
                 ACAGAGGCAGCAGCAGAAGC 
               
               
                 (SEQ ID NO: 73) 
                 (SEQ ID NO: 74) 
               
               
                   
               
               
                 GGGAGCGAGGCAAAGGUCAC 
                 GUGACCUUUGCCUCGCUCCC 
               
               
                 (SEQ ID NO: 75) 
                 (SEQ ID NO: 76) 
               
               
                   
               
               
                 GCAAAGGUCACCCGGAGUUG 
                 CAACUCCGGGUGACCUUUGC 
               
               
                 (SEQ ID NO: 77) 
                 (SEQ ID NO: 78) 
               
               
                   
               
               
                 GGGAUAUAGCUUAAACCUAA 
                 UUAGGUUUAAGCUAUAUCCC 
               
               
                 (SEQ ID NO: 79) 
                 (SEQ ID NO: 80) 
               
               
                   
               
               
                 GGAUAUAGCUUAAACCUAAU 
                 AUUAGGUUUAAGCUAUAUCC 
               
               
                 (SEQ ID NO: 81) 
                 (SEQ ID NO: 82) 
               
               
                   
               
               
                 GUGAGCACCUCCGGGUCUGU 
                 ACAGACCCGGAGGUGCUCAC 
               
               
                 (SEQ ID NO: 83) 
                 (SEQ ID NO: 84) 
               
               
                   
               
               
                 GAGCACCUCCGGGUCUGUCC 
                 GGACAGACCCGGAGGUGCUC 
               
               
                 (SEQ ID NO: 85) 
                 (SEQ ID NO: 86) 
               
               
                   
               
               
                 GGGUCUGUCCCCAGGAGUAC 
                 GUACUCCUGGGGACAGACCC 
               
               
                 (SEQ ID NO: 87) 
                 (SEQ ID NO: 88) 
               
               
                   
               
               
                 GGUCUGUCCCCAGGAGUACA 
                 UGUACUCCUGGGGACAGACC 
               
               
                 (SEQ ID NO: 89) 
                 (SEQ ID NO: 90) 
               
               
                   
               
               
                 GUCUGUCCCCAGGAGUACAC 
                 GUGUACUCCUGGGGACAGAC 
               
               
                 (SEQ ID NO: 91) 
                 (SEQ ID NO: 92) 
               
               
                   
               
               
                 GCGGCUCCUUUCUGGUUCAC 
                 GUGAACCAGAAAGGAGCCGC 
               
               
                 (SEQ ID NO: 93) 
                 (SEQ ID NO: 94) 
               
               
                   
               
               
                 GGCUCCUUUCUGGUUCACAC 
                 GUGUGAACCAGAAAGGAGCC 
               
               
                 (SEQ ID NO: 95) 
                 (SEQ ID NO: 96) 
               
               
                   
               
               
                 GCUCUUCUCCCACUCCUACG 
                 CGUAGGAGUGGGAGAAGAGC 
               
               
                 (SEQ ID NO: 97) 
                 (SEQ ID NO: 98) 
               
               
                   
               
               
                 GCCCAGCACGCCCUCAUAUU 
                 AAUAUGAGGGCGUGCUGGGC 
               
               
                 (SEQ ID NO: 99) 
                 (SEQ ID NO: 100) 
               
               
                   
               
               
                 GCACGCCCUCAUAUUCAAUG 
                 CAUUGAAUAUGAGGGCGUGC 
               
               
                 (SEQ ID NO: 101) 
                 (SEQ ID NO: 102) 
               
               
                   
               
               
                 GCUGCUGCACCCACAGUACA 
                 UGUACUGUGGGUGCAGCAGC 
               
               
                 (SEQ ID NO: 103) 
                 (SEQ ID NO: 104) 
               
               
                   
               
               
                 GGCCUGGAGACUGGAAGAAA 
                 UUUCUUCCAGUCUCCAGGCC 
               
               
                 (SEQ ID NO: 105) 
                 (SEQ ID NO: 106) 
               
               
                   
               
               
                 GCCUGGAGACUGGAAGAAAU 
                 AUUUCUUCCAGUCUCCAGGC 
               
               
                 (SEQ ID NO: 107) 
                 (SEQ ID NO: 108) 
               
               
                   
               
               
                 GCUUAAGGUGCCGGUGUCUG 
                 CAGACACCGGCACCUUAAGC 
               
               
                 (SEQ ID NO: 109) 
                 (SEQ ID NO: 110) 
               
               
                   
               
               
                 GGCAACUAUCUGGAUGGUCU 
                 AGACCAUCCAGAUAGUUGCC 
               
               
                 (SEQ ID NO: 111) 
                 (SEQ ID NO: 112) 
               
               
                   
               
               
                 GCAACUAUCUGGAUGGUCUC 
                 GAGACCAUCCAGAUAGUUGC 
               
               
                 (SEQ ID NO: 113) 
                 (SEQ ID NO: 114) 
               
               
                   
               
               
                 GGAAAACAGUGCGAAGGUGU 
                 ACACCUUCGCACUGUUUUCC 
               
               
                 (SEQ ID NO: 115) 
                 (SEQ ID NO: 116) 
               
               
                   
               
               
                 GAAAACAGUGCGAAGGUGUC 
                 GACACCUUCGCACUGUUUUC 
               
               
                 (SEQ ID NO: 117) 
                 (SEQ ID NO: 118) 
               
               
                   
               
               
                 GGACAGCAGUAUGCAGAUGA 
                 UCAUCUGCAUACUGCUGUCC 
               
               
                 (SEQ ID NO: 119) 
                 (SEQ ID NO: 120) 
               
               
                   
               
               
                 GACAGCAGUAUGCAGAUGAC 
                 GUCAUCUGCAUACUGCUGUC 
               
               
                 (SEQ ID NO: 121) 
                 (SEQ ID NO: 122) 
               
               
                   
               
               
                 ACAGCAGUAUGCAGAUGACU 
                 AGUCAUCUGCAUACUGCUGU 
               
               
                 (SEQ ID NO: 123) 
                 (SEQ ID NO: 124) 
               
               
                   
               
               
                 GCCUCCUCGGCCUCCAUACC 
                 GGUAUGGAGGCCGAGGAGGC 
               
               
                 (SEQ ID NO: 125) 
                 (SEQ ID NO: 126) 
               
               
                   
               
               
                 GGCCUCCAUACCCUCCUAGA 
                 UCUAGGAGGGUAUGGAGGCC 
               
               
                 (SEQ ID NO: 127) 
                 (SEQ ID NO: 128) 
               
               
                   
               
               
                 GCCUCCAUACCCUCCUAGAA 
                 UUCUAGGAGGGUAUGGAGGC 
               
               
                 (SEQ ID NO: 129) 
                 (SEQ ID NO: 130) 
               
               
                   
               
               
                 ACCCAAACCAUCCUCAUUCU 
                 AGAAUGAGGAUGGUUUGGGU 
               
               
                 (SEQ ID NO: 131) 
                 (SEQ ID NO: 132) 
               
               
                   
               
               
                 GGGUGCCCUAGCAUCAGAAG 
                 UUCUGAUGCUAGGGCACCC 
               
               
                 (SEQ ID NO: 133) 
                 (SEQ ID NO: 134) 
               
               
                   
               
               
                 GGGCUGCAGAGAGGGUAGAG 
                 CUCUACCCUCUCUGCAGCCC 
               
               
                 (SEQ ID NO: 135) 
                 (SEQ ID NO: 136) 
               
               
                   
               
               
                 GGCUGCAGAGAGGGUAGAGA 
                 UCUCUACCCUCUCUGCAGCC 
               
               
                 (SEQ ID NO: 137) 
                 (SEQ ID NO: 138) 
               
               
                   
               
               
                 GCUGCAGAGAGGGUAGAGAA 
                 UUCUCUACCCUCUCUGCAGC 
               
               
                 (SEQ ID NO: 139) 
                 (SEQ ID NO: 140) 
               
               
                   
               
               
                 GAGGGUAGAGAAGGGACUUU 
                 AAAGUCCCUUCUCUACCCUC 
               
               
                 (SEQ ID NO: 141) 
                 (SEQ ID NO: 142) 
               
               
                   
               
               
                 AUUUAUUUAGGAGGGAGUGU 
                 ACACUCCCUCCUAAAUAAAU 
               
               
                 (SEQ ID NO: 143) 
                 (SEQ ID NO: 144) 
               
               
                   
               
               
                 GGUGAUCAGCCCCAACAGAG 
                 CUCUGUUGGGGCUGAUCACC 
               
               
                 (SEQ ID NO: 145) 
                 (SEQ ID NO: 146) 
               
               
                   
               
               
                 AGCCCCAACAGAGAAAAUGA 
                 UCAUUUUCUCUGUUGGGGCU 
               
               
                 (SEQ ID NO: 147) 
                 (SEQ ID NO: 148) 
               
               
                   
               
               
                 GCCCCAACAGAGAAAAUGAG 
                 CUCAUUUUCUCUGUUGGGGC 
               
               
                 (SEQ ID NO: 149) 
                 (SEQ ID NO: 150) 
               
               
                   
               
               
                 AACAGAGAAAAUGAGGAGUU 
                 AACUCCUCAUUUUCUCUGUU 
               
               
                 (SEQ ID NO: 151) 
                 (SEQ ID NO: 152) 
               
               
                   
               
               
                 GAGAAAAUGAGGAGUUUAGA 
                 UCUAAACUCCUCAUUUUCUC 
               
               
                 (SEQ ID NO: 153) 
                 (SEQ ID NO: 154) 
               
               
                   
               
               
                 GAAAAUGAGGAGUUUAGAGU 
                 ACUCUAAACUCCUCAUUUUC 
               
               
                 (SEQ ID NO: 155) 
                 (SEQ ID NO: 156) 
               
               
                   
               
               
                 AAAAUGAGGAGUUUAGAGUU 
                 AACUCUAAACUCCUCAUUUU 
               
               
                 (SEQ ID NO: 157) 
                 (SEQ ID NO: 158) 
               
               
                   
               
               
                 GGGACUGAGGGUGCUUGAGU 
                 ACUCAAGCACCCUCAGUCCC 
               
               
                 (SEQ ID NO: 159) 
                 (SEQ ID NO: 160) 
               
               
                   
               
               
                 GGACUGAGGGUGCUUGAGUA 
                 UACUCAAGCACCCUCAGUCC 
               
               
                 (SEQ ID NO: 161) 
                 (SEQ ID NO: 162) 
               
               
                   
               
               
                 GACUGAGGGUGCUUGAGUAG 
                 CUACUCAAGCACCCUCAGUC 
               
               
                 (SEQ ID NO: 163) 
                 (SEQ ID NO: 164) 
               
               
                   
               
               
                 GGUGCUUGAGUAGGAUGUGA 
                 UCACAUCCUACUCAAGCACC 
               
               
                 (SEQ ID NO: 165) 
                 (SEQ ID NO: 166) 
               
               
                   
               
               
                 GUGCUUGAGUAGGAUGUGAG 
                 CUCACAUCCUACUCAAGCAC 
               
               
                 (SEQ ID NO: 167) 
                 (SEQ ID NO: 168) 
               
               
                   
               
               
                 GCUUGAGUAGGAUGUGAGAC 
                 GUCUCACAUCCUACUCAAGC 
               
               
                 (SEQ ID NO: 169) 
                 (SEQ ID NO: 170) 
               
               
                   
               
               
                 GUAGGAUGUGAGACUUCAUG 
                 CAUGAAGUCUCACAUCCUAC 
               
               
                 (SEQ ID NO: 171) 
                 (SEQ ID NO: 172) 
               
               
                   
               
               
                 GGGUGCUCAUCUCGUGACCU 
                 AGGUCACGAGAUGAGCACCC 
               
               
                 (SEQ ID NO: 173) 
                 (SEQ ID NO: 174) 
               
               
                   
               
               
                 GGUGCUCAUCUCGUGACCUC 
                 GAGGUCACGAGAUGAGCACC 
               
               
                 (SEQ ID NO: 175) 
                 (SEQ ID NO: 176) 
               
               
                   
               
               
                 GUGCUCAUCUCGUGACCUCU 
                 AGAGGUCACGAGAUGAGCAC 
               
               
                 (SEQ ID NO: 177) 
                 (SEQ ID NO: 178) 
               
               
                   
               
               
                 GCCACCCACAUCCUUCACAA 
                 UUGUGAAGGAUGUGGGUGGC 
               
               
                 (SEQ ID NO: 179) 
                 (SEQ ID NO: 180) 
               
               
                   
               
               
                 ACCCACAUCCUUCACAAACU 
                 AGUUUGUGAAGGAUGUGGGU 
               
               
                 (SEQ ID NO: 181) 
                 (SEQ ID NO: 182) 
               
               
                   
               
               
                 GCAAAUAAAUGGUAAUGUAU 
                 AUACAUUACCAUUUAUUUGC 
               
               
                 (SEQ ID NO: 183) 
                 (SEQ ID NO: 184) 
               
               
                   
               
               
                 GGGAUAUAGCUUAAACCUAAU 
                 AUUAGGUUUAAGCUAUAUCCC 
               
               
                 (SEQ ID NO: 185) 
                 (SEQ ID NO: 186) 
               
               
                   
               
               
                 GGCCUGGAGACUGGAAGAAAU 
                 AUUUCUUCCAGUCUCCAGGCC 
               
               
                 (SEQ ID NO: 187) 
                 (SEQ ID NO: 188) 
               
               
                   
               
               
                 GGGCAACUAUCUGGAUGGUCU 
                 AGACCAUCCAGAUAGUUGCCC 
               
               
                 (SEQ ID NO: 189) 
                 (SEQ ID NO: 190) 
               
               
                   
               
               
                 GGGACAGCAGUAUGCAGAUGA 
                 UCAUCUGCAUACUGCUGUCCC 
               
               
                 (SEQ ID NO: 191) 
                 (SEQ ID NO: 192) 
               
               
                   
               
               
                 GACAGCAGUAUGCAGAUGACU 
                 AGUCAUCUGCAUACUGCUGUC 
               
               
                 (SEQ ID NO: 193) 
                 (SEQ ID NO: 194) 
               
               
                   
               
               
                 GGGUGCUUGAGUAGGAUGUGA 
                 UCACAUCCUACUCAAGCACCC 
               
               
                 (SEQ ID NO: 195) 
                 (SEQ ID NO: 196) 
               
               
                   
               
               
                 GUGCUUGAGUAGGAUGUGAGA 
                 UCUCACAUCCUACUCAAGCAC 
               
               
                 (SEQ ID NO: 197) 
                 (SEQ ID NO: 198) 
               
               
                   
               
               
                 GCUUGAGUAGGAUGUGAGACU 
                 AGUCUCACAUCCUACUCAAGC 
               
               
                 (SEQ ID NO: 199) 
                 (SEQ ID NO: 200) 
               
               
                   
               
               
                 GCCACCCACAUCCUUCACAAA 
                 UUUGUGAAGGAUGUGGGUGGC 
               
               
                 (SEQ ID NO: 201) 
                 (SEQ ID NO: 202) 
               
               
                   
               
            
           
         
       
     
     In some embodiments, the siRNA targeting GPC2 comprises a sense region encoded by a first single stranded RNA molecule and an anti-sense region is encoded by a second single stranded RNA molecule, the anti-sense region is complementary to the sense region, and the first and second single stranded RNA molecules further comprise 3′ overhangs. In some embodiments, the first single stranded RNA comprises or consists essentially of a sequence selected from the group listed in Table 3. In some embodiments, the second single stranded RNA comprises or consists essentially of a sequence selected from the group listed in Table 3. In some embodiments, the first and second single stranded RNAs are complementary sequences, exclusive of the 3′ overhangs, selected from the group listed in Table 3. 
     Exemplary sequences of first single stranded RNAs comprising the sense region and second single stranded RNAs comprising the anti-sense region, with dinucleotide 3′ overhangs are shown in table 3 below. Each row of the table shows pairs of first and second single stranded RNAs capable of hybridizing to form the mature duplex siRNA. 
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Representative GPC2 siRNAs 
               
            
           
           
               
               
            
               
                 Sense 
                 Anti-sense 
               
               
                   
               
               
                 CUCCUGAUCCUGGCUGAUA 
                 UAUCAGCCAGGAUCAGGAG[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 203) 
                 (SEQ ID NO: 204) 
               
               
                   
               
               
                 CUCAUCUACCGAUGGCUCU 
                 AGAGCCAUCGGUAGAUGAG[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 205) 
                 (SEQ ID NO: 206) 
               
               
                   
               
               
                 CCUGCUUGGACCUCGAUAA 
                 UUAUCGAGGUCCAAGCAGG[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 207) 
                 (SEQ ID NO: 208) 
               
               
                   
               
               
                 GUGGUUCGUGGCUGUCUCA 
                 UGAGACAGCCACGAACCAC[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 209) 
                 (SEQ ID NO: 210) 
               
               
                   
               
               
                 CUCAGUAGCCCAGCACUCU 
                 AGAGUGCUGGGCUACUGAG[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 211) 
                 (SEQ ID NO: 212) 
               
               
                   
               
               
                 CUGCUGUUCCAGUGAGACA 
                 UGUCUCACUGGAACAGCAG[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 213) 
                 (SEQ ID NO: 214) 
               
               
                   
               
               
                 CUCCUUUCUGGUUCACACA 
                 UGUGUGAACCAGAAAGGAG[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 215) 
                 (SEQ ID NO: 216) 
               
               
                   
               
               
                 GAGUGUGGUUUCCUUAGAA 
                 UUCUAAGGAAACCACACUC[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 217) 
                 (SEQ ID NO: 218) 
               
               
                   
               
               
                 GAGUACACCUGCUGUUCCA 
                 UGGAACAGCAGGUGUACUC[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 219) 
                 (SEQ ID NO: 220) 
               
               
                   
               
               
                 GACACGACCUGGACGGGCA 
                 UGCCCGUCCAGGUCGUGUC[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 221) 
                 (SEQ ID NO: 222) 
               
               
                   
               
               
                 CUGACUACCUGCUCUGCCU 
                 AGGCAGAGCAGGUAGUCAG[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 223) 
                 (SEQ ID NO: 224) 
               
               
                   
               
               
                 GCGCUUAAGGUGCCGGUGU 
                 ACACCGGCACCUUAAGCGC[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 225) 
                 (SEQ ID NO: 226) 
               
               
                   
               
               
                 CCUUUGAGCUGACGGCCGA 
                 UCGGCCGUCAGCUCAAAGG[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 227) 
                 (SEQ ID NO: 228) 
               
               
                   
               
               
                 CCUGCUUCUGCUGCUGCCU 
                 AGGCAGCAGCAGAAGCAGG[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 229) 
                 (SEQ ID NO: 230) 
               
               
                   
               
               
                 GAAGAAAUGUGGUCAGCGA 
                 UCGCUGACCACAUUUCUUC[dT][dT] 
               
               
                 [dT][dT] 
                   
               
               
                 (SEQ ID NO: 231) 
                 (SEQ ID NO: 232) 
               
               
                   
               
            
           
         
       
     
     Unless otherwise indicated, sequences in the Tables refer to ribonucleic acids (RNA). d[T] refers to deoxyribonucleic acids (DNA). 
     siRNAs can be designed using commercially available design tools and kits, such as those available from Ambion, Inc. (Austin, Tex.), the Whitehead Institute of Biomedical Research at MIT (Cambridge, Mass.), Invivogen (www.invivogen.com/sirnawizard/siRNA.php) and ThermoFisher (rnaidesigner.thermofisher.com/rnaiexpress/design.do) allow for the design and production of siRNA. siRNAs can also be designed using the Designer of Small Interfering RNA (DSIR) web-based tool available at biodev.extra.cea.fr/DSIR/DSIR.html. Using DSIR, siRNAs are designed and given a score based on the predicted efficacy of the siRNA based on a 19 or 21 nucleotide model. 
     In some embodiments, the siRNA comprises an RNA duplex that is 21 nucleotides in length. In some embodiments, the RNA duplex comprises a sense region and an antisense region that are selected from the group of sequences in Table 4. 
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 siRNA sense regions and anti-sense regions, 21 bp in length 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 SEQ 
                   
                 SEQ 
                   
                   
                 Corr. 
               
               
                 Pos. 
                 ID NO: 
                 Sense Region 
                 ID NO: 
                 Antisense Region 
                 Score 
                 Score 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                    1 
                  233 
                 UCCCAUUGUCUCGGCAGAUGC 
                 1477 
                 AUCUGCCGAGACAAUGGGAGC 
                 60.2 
                 60.2 
               
               
                   
               
               
                    2 
                  234 
                 CCCAUUGUCUCGGCAGAUGCC 
                 1478 
                 CAUCUGCCGAGACAAUGGGAG 
                 67.5 
                 67.5 
               
               
                   
               
               
                    3 
                  235 
                 CCAUUGUCUCGGCAGAUGCCG 
                 1479 
                 GCAUCUGCCGAGACAAUGGGA 
                 68.3 
                 68.3 
               
               
                   
               
               
                    4 
                  236 
                 CAUUGUCUCGGCAGAUGCCGC 
                 1480 
                 GGCAUCUGCCGAGACAAUGGG 
                 64.7 
                 64.7 
               
               
                   
               
               
                    5 
                  237 
                 AUUGUCUCGGCAGAUGCCGCC 
                 1481 
                 CGGCAUCUGCCGAGACAAUGG 
                 49.5 
                 49.5 
               
               
                   
               
               
                    6 
                  238 
                 UUGUCUCGGCAGAUGCCGCCU 
                 1482 
                 GCGGCAUCUGCCGAGACAAUG 
                 48.4 
                 48.4 
               
               
                   
               
               
                    7 
                  239 
                 UGUCUCGGCAGAUGCCGCCUG 
                 1483 
                 GGCGGCAUCUGCCGAGACAAU 
                 43.5 
                 43.5 
               
               
                   
               
               
                    8 
                  240 
                 GUCUCGGCAGAUGCCGCCUGG 
                 1484 
                 AGGCGGCAUCUGCCGAGACAA 
                 61.2 
                 61.2 
               
               
                   
               
               
                    9 
                  241 
                 UCUCGGCAGAUGCCGCCUGGU 
                 1485 
                 CAGGCGGCAUCUGCCGAGACA 
                 49.5 
                 49.5 
               
               
                   
               
               
                   10 
                  242 
                 CUCGGCAGAUGCCGCCUGGUC 
                 1486 
                 CCAGGCGGCAUCUGCCGAGAC 
                 47.8 
                 47.8 
               
               
                   
               
               
                   11 
                  243 
                 UCGGCAGAUGCCGCCUGGUCC 
                 1487 
                 ACCAGGCGGCAUCUGCCGAGA 
                 55 
                 55 
               
               
                   
               
               
                   12 
                  244 
                 CGGCAGAUGCCGCCUGGUCCA 
                 1488 
                 GACCAGGCGGCAUCUGCCGAG 
                 65.2 
                 65.2 
               
               
                   
               
               
                   13 
                  245 
                 GGCAGAUGCCGCCUGGUCCAG 
                 1489 
                 GGACCAGGCGGCAUCUGCCGA 
                 61.6 
                 61.6 
               
               
                   
               
               
                   14 
                  246 
                 GCAGAUGCCGCCUGGUCCAGC 
                 1490 
                 UGGACCAGGCGGCAUCUGCCG 
                 79.9 
                 79.9 
               
               
                   
               
               
                   15 
                  247 
                 CAGAUGCCGCCUGGUCCAGCU 
                 1491 
                 CUGGACCAGGCGGCAUCUGCC 
                 52 
                 52 
               
               
                   
               
               
                   16 
                  248 
                 AGAUGCCGCCUGGUCCAGCAU 
                 1492 
                 GCUGGACCAGGCGGCAUCUGC 
                 42.4 
                 42.4 
               
               
                   
               
               
                   17 
                  249 
                 GAUGCCGCCUGGUCCAGCUAU 
                 1493 
                 AGCUGGACCAGGCGGCAUCUG 
                 71.1 
                 71.1 
               
               
                   
               
               
                   18 
                  250 
                 AUGCCGCCUGGUCCAGCUAUC 
                 1494 
                 UAGCUGGACCAGGCGGCAUCU 
                 71.4 
                 71.4 
               
               
                   
               
               
                   19 
                  251 
                 UGCCGCCUGGUCCAGCUAUCG 
                 1495 
                 AUAGCUGGACCAGGCGGCAUC 
                 61.3 
                 61.3 
               
               
                   
               
               
                   20 
                  252 
                 GCCGCCUGGUCCAGCUAUCGU 
                 1496 
                 GAUAGCUGGACCAGGCGGCAU 
                 66.6 
                 66.6 
               
               
                   
               
               
                   21 
                  253 
                 CCGCCUGGUCCAGCUAUCGUG 
                 1497 
                 CGAUAGCUGGACCAGGCGGCA 
                 57.7 
                 57.7 
               
               
                   
               
               
                   22 
                  254 
                 CGCCUGGUCCAGCUAUCGUGC 
                 1498 
                 ACGAUAGCUGGACCAGGCGGC 
                 68.2 
                 68.2 
               
               
                   
               
               
                   23 
                  255 
                 GCCUGGUCCAGCUAUCGUGCU 
                 1499 
                 CACGAUAGCUGGACCAGGCGG 
                 73.4 
                 73.4 
               
               
                   
               
               
                   24 
                  256 
                 CCUGGUCCAGCUAUCGUGCUC 
                 1500 
                 GCACGAUAGCUGGACCAGGCG 
                 61.3 
                 61.3 
               
               
                   
               
               
                   25 
                  257 
                 CUGGUCCAGCUAUCGUGCUCG 
                 1501 
                 AGCACGAUAGCUGGACCAGGC 
                 61.9 
                 61.9 
               
               
                   
               
               
                   26 
                  258 
                 UGGUCCAGCUAUCGUGCUCGG 
                 1502 
                 GAGCACGAUAGCUGGACCAGG 
                 64 
                 64 
               
               
                   
               
               
                   27 
                  259 
                 GGUCCAGCUAUCGUGCUCGGU 
                 1503 
                 CGAGCACGAUAGCUGGACCAG 
                 64.4 
                 64.4 
               
               
                   
               
               
                   28 
                  260 
                 GUCCAGCUAUCGUGCUCGGUA 
                 1504 
                 CCGAGCACGAUAGCUGGACCA 
                 64 
                 64 
               
               
                   
               
               
                   29 
                  261 
                 UCCAGCUAUCGUGCUCGGUAU 
                 1505 
                 ACCGAGCACGAUAGCUGGACC 
                 49.2 
                 49.2 
               
               
                   
               
               
                   30 
                  262 
                 CCAGCUAUCGUGCUCGGUAUU 
                 1506 
                 UACCGAGCACGAUAGCUGGAC 
                 78.1 
                 78.1 
               
               
                   
               
               
                   31 
                  263 
                 CAGCUAUCGUGCUCGGUAUUC 
                 1507 
                 AUACCGAGCACGAUAGCUGGA 
                 87 
                 87 
               
               
                   
               
               
                   32 
                  264 
                 AGCUAUCGUGCUCGGUAUUCA 
                 1508 
                 AAUACCGAGCACGAUAGCUGG 
                 82.9 
                 82.9 
               
               
                   
               
               
                   33 
                  265 
                 GCUAUCGUGCUCGGUAUUCAG 
                 1509 
                 GAAUACCGAGCACGAUAGCUG 
                 65.9 
                 65.9 
               
               
                   
               
               
                   34 
                  266 
                 CUAUCGUGCUCGGUAUUCAGU 
                 1510 
                 UGAAUACCGAGCACGAUAGCU 
                 79 
                 79 
               
               
                   
               
               
                   35 
                  267 
                 UAUCGUGCUCGGUAUUCAGUU 
                 1511 
                 CUGAAUACCGAGCACGAUAGC 
                 60.2 
                 60.2 
               
               
                   
               
               
                   36 
                  268 
                 AUCGUGCUCGGUAUUCAGUUU 
                 1512 
                 ACUGAAUACCGAGCACGAUAG 
                 64.9 
                 64.9 
               
               
                   
               
               
                   55 
                  269 
                 UUUCCGGAGCAGCGCUCUUUC 
                 1513 
                 AAGAGCGCUGCUCCGGAAAAC 
                 59.4 
                 59.4 
               
               
                   
               
               
                   56 
                  270 
                 UUCCGGAGCAGCGCUCUUUCU 
                 1514 
                 AAAGAGCGCUGCUCCGGAAAA 
                 59.6 
                 59.6 
               
               
                   
               
               
                   57 
                  271 
                 UCCGGAGCAGCGCUCUUUCUC 
                 1515 
                 GAAAGAGCGCUGCUCCGGAAA 
                 56.3 
                 56.3 
               
               
                   
               
               
                   58 
                  272 
                 CCGGAGCAGCGCUCUUUCUCU 
                 1516 
                 AGAAAGAGCGCUGCUCCGGAA 
                 75.8 
                 75.8 
               
               
                   
               
               
                   59 
                  273 
                 CGGAGCAGCGCUCUUUCUCUG 
                 1517 
                 GAGAAAGAGCGCUGCUCCGGA 
                 66.5 
                 66.5 
               
               
                   
               
               
                   60 
                  274 
                 GGAGCAGCGCUCUUUCUCUGG 
                 1518 
                 AGAGAAAGAGCGCUGCUCCGG 
                 80.4 
                 80.4 
               
               
                   
               
               
                   79 
                  275 
                 GGCCCGCGGAGCGGUCCCGCG 
                 1519 
                 CGGGACCGCUCCGCGGGCCAG 
                 53.9 
                 53.9 
               
               
                   
               
               
                   80 
                  276 
                 GCCCGCGGAGCGGUCCCGCGG 
                 1520 
                 GCGGGACCGCUCCGCGGGCCA 
                 42.7 
                 42.7 
               
               
                   
               
               
                   81 
                  277 
                 CCCGCGGAGCGGUCCCGCGGC 
                 1521 
                 CGCGGGACCGCUCCGCGGGCC 
                 47.6 
                 47.6 
               
               
                   
               
               
                   82 
                  278 
                 CCGCGGAGCGGUCCCGCGGCC 
                 1522 
                 CCGCGGGACCGCUCCGCGGGC 
                 52.7 
                 52.7 
               
               
                   
               
               
                   83 
                  279 
                 CGCGGAGCGGUCCCGCGGCCG 
                 1523 
                 GCCGCGGGACCGCUCCGCGGG 
                 56.2 
                 56.2 
               
               
                   
               
               
                   84 
                  280 
                 GCGGAGCGGUCCCGCGGCCGA 
                 1524 
                 GGCCGCGGGACCGCUCCGCGG 
                 57.1 
                 57.1 
               
               
                   
               
               
                   85 
                  281 
                 CGGAGCGGUCCCGCGGCCGAG 
                 1525 
                 CGGCCGCGGGACCGCUCCGCG 
                 49.2 
                 49.2 
               
               
                   
               
               
                   86 
                  282 
                 GGAGCGGUCCCGCGGCCGAGU 
                 1526 
                 UCGGCCGCGGGACCGCUCCGC 
                 74.8 
                 74.8 
               
               
                   
               
               
                   87 
                  283 
                 GAGCGGUCCCGCGGCCGAGUA 
                 1527 
                 CUCGGCCGCGGGACCGCUCCG 
                 80.8 
                 60.8 
               
               
                   
               
               
                   88 
                  284 
                 AGCGGUCCCGCGGCCGAGUAC 
                 1528 
                 ACUCGGCCGCGGGACCGCUCC 
                 54.5 
                 54.5 
               
               
                   
               
               
                   89 
                  285 
                 GCGGUCCCGCGGCCGAGUACC 
                 1529 
                 UACUCGGCCGCGGGACCGCUC 
                 73.9 
                 73.9 
               
               
                   
               
               
                   90 
                  286 
                 CGGUCCCGCGGCCGAGUACCG 
                 1530 
                 GUACUCGGCCGCGGGACCGCU 
                 62.1 
                 62.1 
               
               
                   
               
               
                   91 
                  287 
                 GGUCCCGCGGCCGAGUACCGG 
                 1531 
                 GGUACUCGGCCGCGGGACCGC 
                 50.3 
                 50.3 
               
               
                   
               
               
                   92 
                  288 
                 GUCCCGCGGCCGAGUACCGGA 
                 1532 
                 CGGUACUCGGCCGCGGGACCG 
                 55.9 
                 55.9 
               
               
                   
               
               
                   93 
                  289 
                 UCCCGCGGCCGAGUACCGGAU 
                 1533 
                 CCGGUACUCGGCCGCGGGACC 
                 31.9 
                 31.9 
               
               
                   
               
               
                   94 
                  290 
                 CCCGCGGCCGAGUACCGGAUU 
                 1534 
                 UCCGGUACUCGGCCGCGGGAC 
                 68.6 
                 68.6 
               
               
                   
               
               
                   95 
                  291 
                 CCGCGGCCGAGUACCGGAUUC 
                 1535 
                 AUCCGGUACUCGGCCGCGGGA 
                 76.3 
                 76.3 
               
               
                   
               
               
                   96 
                  292 
                 CGCGGCCGAGUACCGGAUUCC 
                 1536 
                 AAUCCGGUACUCGGCCGCGGG 
                 77.9 
                 77.9 
               
               
                   
               
               
                   97 
                  293 
                 GCGGCCGAGUACCGGAUUCGC 
                 1537 
                 GAAUCCGGUACUCGGCCGCGG 
                 71.7 
                 71.7 
               
               
                   
               
               
                   98 
                  294 
                 CGGCCGAGUACCGGAUUCCCG 
                 1538 
                 GGAAUCCGGUACUCGGCCGCG 
                 61.2 
                 61.2 
               
               
                   
               
               
                   99 
                  295 
                 GGCCGAGUACCGGAUUCCCGA 
                 1539 
                 GGGAAUCCGGUACUCGGCCGC 
                 58.7 
                 58.7 
               
               
                   
               
               
                  100 
                  296 
                 GCCGAGUACCGGAUUCCCGAG 
                 1540 
                 CGGGAAUCCGGUACUCGGCCG 
                 64.7 
                 63.7 
               
               
                   
               
               
                  101 
                  297 
                 CCGAGUACCGGAUUCCCGAGU 
                 1541 
                 UCGGGAAUCCGGUACUCGGCC 
                 76.4 
                 75.4 
               
               
                   
               
               
                  102 
                  298 
                 CGAGUACCGGAUUCCCGAGUU 
                 1542 
                 CUCGGGAAUCCGGUACUCGGC 
                 68.9 
                 67.9 
               
               
                   
               
               
                  103 
                  299 
                 GAGUACCGGAUUCCCGAGUUU 
                 1543 
                 ACUCGGGAAUCCGGUACUCGG 
                 73.7 
                 72.7 
               
               
                   
               
               
                  104 
                  300 
                 AGUACCGGAUUCCCGAGUUUG 
                 1544 
                 AACUCGGGAAUCCGGUACUCG 
                 77.4 
                 76.4 
               
               
                   
               
               
                  105 
                  301 
                 GUACCGGAUUCCCGAGUUUGG 
                 1545 
                 AAACUCGGGAAUCCGGUACUC 
                 79.3 
                 78.3 
               
               
                   
               
               
                  106 
                  302 
                 UACCGGAUUCCCGAGUUUGGG 
                 1546 
                 CAAACUCGGGAAUCCGGUACU 
                 59.4 
                 58.4 
               
               
                   
               
               
                  107 
                  303 
                 ACCGGAUUCCCGAGUUUGGGA 
                 1547 
                 CCAAACUCGGGAAUCCGGUAC 
                 59.9 
                 58.9 
               
               
                   
               
               
                  108 
                  304 
                 CCGGAUUCCCGAGUUUGGGAG 
                 1548 
                 CCCAAACUCGGGAAUCCGGUA 
                 60.9 
                 59.9 
               
               
                   
               
               
                  109 
                  305 
                 CGGAUUCCCGAGUUUGGGAGG 
                 1549 
                 UCCCAAACUCGGGAAUCCGGU 
                 30.2 
                 79.2 
               
               
                   
               
               
                  110 
                  306 
                 GGAUUCCCGAGUUUGGGAGGG 
                 1550 
                 GUCCCAAACUCGGGAAUCCGG 
                 68.1 
                 67.1 
               
               
                   
               
               
                  111 
                  307 
                 GAUUCCCGAGUUUGGGAGGCU 
                 1551 
                 CCUCCCAAACUCGGGAAUCCG 
                 59.3 
                 58.3 
               
               
                   
               
               
                  112 
                  308 
                 AUUCCCGAGUUUGGGAGGCUC 
                 1552 
                 GCCUCCCAAACUCGGGAAUCC 
                 33.2 
                 32.2 
               
               
                   
               
               
                  113 
                  309 
                 UUCCCGAGUUUGGGAGGCUCU 
                 1553 
                 AGCCUCCCAAACUCGGGAAUC 
                 47.8 
                 46.8 
               
               
                   
               
               
                  114 
                  310 
                 UCCCGAGUUUGGGAGGCUCUG 
                 1554 
                 GAGCCUCCCAAACUCGGGAAU 
                 54.2 
                 53.2 
               
               
                   
               
               
                  115 
                  311 
                 CCCGAGUUUGGGAGGCUCUGC 
                 1555 
                 AGAGCCUCCCAAACUCGGGAA 
                 72.3 
                 71.3 
               
               
                   
               
               
                  116 
                  312 
                 CCGAGUUUGGGAGGCUCUGCU 
                 1556 
                 CAGAGCCUCCCAAACUCGGGA 
                 68.3 
                 67.3 
               
               
                   
               
               
                  117 
                  313 
                 CGAGUUUGGGAGGCUCUGCUU 
                 1557 
                 GCAGAGCCUCCCAAACUCGGG 
                 64 
                 63 
               
               
                   
               
               
                  118 
                  314 
                 GAGUUUGGGAGGCUCUGCUUU 
                 1558 
                 AGCAGAGCCUCCCAAACUCGG 
                 72.8 
                 71.8 
               
               
                   
               
               
                  119 
                  315 
                 AGUUUGGGAGGCUCUGCUUUC 
                 1559 
                 AAGCAGAGCCUCCCAAACUCG 
                 7.58 
                 74.8 
               
               
                   
               
               
                  120 
                  316 
                 GUUUGGGAGGCUCUGCUUUCC 
                 1560 
                 AAAGCAGAGCCUCCCAAACUC 
                 69 
                 68 
               
               
                   
               
               
                  121 
                  317 
                 UUUGGGAGGCUCUGCUUUCCU 
                 1561 
                 GAAAGCAGAGCCUCCCAAACU 
                 49 
                 48 
               
               
                   
               
               
                  122 
                  318 
                 UUGGGAGGCUCUGCUUUCCUC 
                 1562 
                 GGAAAGCAGAGCCUCCCAAAC 
                 37.8 
                 36.8 
               
               
                   
               
               
                  123 
                  319 
                 UGGGAGGCUCUGCUUUCCUCC 
                 1563 
                 AGGAAAGCAGAGCCUCCCAAA 
                 61.1 
                 60.1 
               
               
                   
               
               
                  124 
                  320 
                 GGGAGGCUCUGCUUUCCUCCU 
                 1564 
                 GAGGAAAGCAGAGCCUCCCAA 
                 69 
                 68 
               
               
                   
               
               
                  125 
                  321 
                 GGAGGCUCUGCUUUCCUCCUU 
                 1565 
                 GGAGGAAAGCAGAGCCUCCCA 
                 59.2 
                 58.2 
               
               
                   
               
               
                  126 
                  322 
                 GAGGCUCUGCUUUCCUCCUUA 
                 1566 
                 AGGAGGAAAGCAGAGCCUCCC 
                 66.8 
                 65.8 
               
               
                   
               
               
                  127 
                  323 
                 AGGCUCUGCUUUCCUCCUUAG 
                 1567 
                 AAGGAGGAAAGCAGAGCCUCC 
                 66.5 
                 65.5 
               
               
                   
               
               
                  128 
                  324 
                 GGCUCUGCUUUCCUCCUUAGG 
                 1568 
                 UAAGGAGGAAAGCAGAGCCUC 
                 87.2 
                 86.2 
               
               
                   
               
               
                  129 
                  325 
                 GCUCUGCUUUCCUCCUUAGGA 
                 1569 
                 CUAAGGAGGAAAGCAGAGCCU 
                 75.7 
                 74.7 
               
               
                   
               
               
                  130 
                  326 
                 CUCUGCUUUCCUCCUUAGGAC 
                 1570 
                 CCUAAGGAGGAAAGCAGAGCC 
                 52.3 
                 51.3 
               
               
                   
               
               
                  131 
                  327 
                 UCUGCUUUCCUCCUUAGGACC 
                 1571 
                 UCCUAAGGAGGAAAGCAGAGC 
                 64.3 
                 53.3 
               
               
                   
               
               
                  132 
                  328 
                 CUGCUUUCCUCCUUAGGACCC 
                 1572 
                 GUCCUAAGGAGGAAAGCAGAG 
                 66.2 
                 65.2 
               
               
                   
               
               
                  133 
                  329 
                 UGCUUUCCUCCUUAGGACCCA 
                 1573 
                 GGUCCUAAGGAGGAAAGCAGA 
                 55.9 
                 54.9 
               
               
                   
               
               
                  134 
                  330 
                 GCUUUCCUCCUUAGGACCCAC 
                 1574 
                 GGGUCCUAAGGAGGAAAGCAG 
                 58.5 
                 57.5 
               
               
                   
               
               
                  135 
                  331 
                 CUUUCCUCCUUAGGACCCACU 
                 1575 
                 UGGGUCCUAAGGAGGAAAGCA 
                 68.6 
                 67.6 
               
               
                   
               
               
                  136 
                  332 
                 UUUCCUCCUUAGGACCCACUU 
                 1576 
                 GUGGGUCCUAAGGAGGAAAGC 
                 46 
                 45 
               
               
                   
               
               
                  137 
                  333 
                 UUCCUCCUUAGGACCCACUUU 
                 1577 
                 AGUGGGUCCUAAGGAGGAAAG 
                 53.8 
                 52.8 
               
               
                   
               
               
                  138 
                  334 
                 UCCUCCUUAGGACCCACUUUG 
                 1578 
                 AAGUGGGUCCUAAGGAGGAAA 
                 66.4 
                 65.4 
               
               
                   
               
               
                  139 
                  335 
                 CCUCCUUAGGACCCACUUUGC 
                 1579 
                 AAAGUGGGUCCUAAGGAGGAA 
                 79.9 
                 78.9 
               
               
                   
               
               
                  140 
                  336 
                 CUCCUUAGGACCCACUUUGCC 
                 1580 
                 CAAAGUGGGUCCUAAGGAGGA 
                 66 
                 65 
               
               
                   
               
               
                  141 
                  337 
                 UCCUUAGGACCCACUUUGCCG 
                 1581 
                 GCAAAGUGGGUCCUAAGGAGG 
                 55.6 
                 54.6 
               
               
                   
               
               
                  142 
                  338 
                 CCUUAGGACCCACUUUGCCGU 
                 1582 
                 GGCAAAGUGGGUCCUAAGGAG 
                 58.2 
                 57.2 
               
               
                   
               
               
                  143 
                  339 
                 CUUAGGACCCACUUUGCCGUC 
                 1583 
                 CGGCAAAGUGGGUCCUAAGGA 
                 55.8 
                 54.8 
               
               
                   
               
               
                  144 
                  340 
                 UAGGACCCACUUUGCCGUCCU 
                 1584 
                 ACGGCAAAGUGGGUCCUAAGG 
                 54.6 
                 53.6 
               
               
                   
               
               
                  145 
                  341 
                 UAGGACCCACUUUGCCGUCCU 
                 1585 
                 GACGGCAAAGUGGGUCCUAAG 
                 47.2 
                 46.2 
               
               
                   
               
               
                  146 
                  342 
                 AGGACCCACUUUGCCGUCCUG 
                 1586 
                 GGACGGCAAAGUGGGUCCUAA 
                 47.4 
                 46.4 
               
               
                   
               
               
                  147 
                  348 
                 GGACCCACUUUGCCGUCCUGG 
                 1587 
                 AGGACGGCAAAGUGGGUCCUA 
                 74.4 
                 73.4 
               
               
                   
               
               
                  148 
                  344 
                 GACCCACUUUGCCGUCCUGGG 
                 1588 
                 CAGGACGGCAAAGUGGGUCCU 
                 66.1 
                 55.1 
               
               
                   
               
               
                  171 
                  345 
                 GGCUGCAGUUAUGUCCGCGCU 
                 1589 
                 CGCGGACAUAACUGCAGCCAC 
                 58 
                 57 
               
               
                   
               
               
                  172 
                  346 
                 GCUGCAGUUAUGUCCGCGCUG 
                 1590 
                 GCGCGGACAUAACUGCAGCCA 
                 64.4 
                 53.4 
               
               
                   
               
               
                  173 
                  347 
                 CUGCAGUUAUGUCCGCGCUGC 
                 1591 
                 AGCGCGGACAUAACUGCAGCC 
                 67.3 
                 66.3 
               
               
                   
               
               
                  174 
                  348 
                 UGCAGUUAUGUCCGCGCUGCG 
                 1592 
                 CAGCGCGGACAUAACUGCAGC 
                 59.4 
                 58.4 
               
               
                   
               
               
                  175 
                  349 
                 GCAGUUAUGUCCGCGCUGCGA 
                 1593 
                 GCAGCGCGGACAUAACUGCAG 
                 66.9 
                 65.9 
               
               
                   
               
               
                  176 
                  350 
                 CAGUUAUGUCCGCGCUGCGAC 
                 1594 
                 CGCAGCGCGGACAUAACUGCA 
                 65.7 
                 64.7 
               
               
                   
               
               
                  177 
                  351 
                 AGUUAUGUCCGCGCUGCGACC 
                 1595 
                 UCGCAGCGCGGACAUAACUGC 
                 76.5 
                 75.5 
               
               
                   
               
               
                  178 
                  352 
                 GUUAUGUCCGCGCUGCGACCU 
                 1596 
                 GUCGCAGCGCGGACAUAACUG 
                 68.4 
                 67.4 
               
               
                   
               
               
                  179 
                  353 
                 UUAUGUCCGCGCUGCGACCUC 
                 1597 
                 GGUCGCAGCGCGGACAUAACU 
                 49.4 
                 48.4 
               
               
                   
               
               
                  180 
                  354 
                 UAUGUCCGCGCUGCGACCUCU 
                 1598 
                 AGGUCGCAGCGCGGACAUAAC 
                 49.2 
                 48.2 
               
               
                   
               
               
                  181 
                  355 
                 AUGUCCGCGCUGCGACCUCUC 
                 1599 
                 GAGGUCGCAGCGCGGACAUAA 
                 56.7 
                 55.7 
               
               
                   
               
               
                  182 
                  356 
                 UGUCCGCGCUGCGACCUCUCC 
                 1600 
                 AGAGGUCGCAGCGCGGACAUA 
                 70.6 
                 69.6 
               
               
                   
               
               
                  183 
                  357 
                 GUCCGCGCUGCGACCUCUCCU 
                 1601 
                 GAGAGGUCGCAGCGCGGACAU 
                 63.1 
                 62.1 
               
               
                   
               
               
                  184 
                  358 
                 UCCGCGCUGCGACCUCUCCUG 
                 1602 
                 GGAGAGGUCGCAGCGCGGACA 
                 50.6 
                 49.6 
               
               
                   
               
               
                  185 
                  359 
                 CCGCGCUGCGACCUCUCCUGC 
                 1603 
                 AGGAGAGGUCGCAGCGCGGAC 
                 65.3 
                 64.3 
               
               
                   
               
               
                  186 
                  360 
                 CGCGCUGCGACCUCUCCUGCU 
                 1604 
                 CAGGAGAGGUCGCAGCGCGGA 
                 72.8 
                 71.8 
               
               
                   
               
               
                  187 
                  361 
                 GCGCUGCGACCUCUCCUGCUU 
                 1605 
                 GCAGGAGAGGUCGCAGCGCGG 
                 67.1 
                 66.1 
               
               
                   
               
               
                  188 
                  362 
                 CGCUGCGACCUCUCCUGCUUC 
                 1806 
                 AGCAGGAGAGGUCGCAGCGCG 
                 76.1 
                 75.1 
               
               
                   
               
               
                  189 
                  363 
                 GCUGCGACCUCUCCUGCUUCU 
                 1607 
                 AAGCAGGAGAGGUCGCAGCGC 
                 83.4 
                 82.4 
               
               
                   
               
               
                  190 
                  364 
                 CUGCGACCUCUCCUGCUUCUG 
                 1608 
                 GAAGCAGGAGAGGUCGCAGCG 
                 66 
                 65 
               
               
                   
               
               
                  191 
                  365 
                 UGCGACCUCUCCUGCUUCUGC 
                 1609 
                 AGAAGCAGGAGAGGUCGCAGC 
                 65.8 
                 64.8 
               
               
                   
               
               
                  192 
                  366 
                 GCGACCUCUCCUGCUUCUGCU 
                 1610 
                 CAGAAGCAGGAGAGGUCGCAG 
                 71.4 
                 70.4 
               
               
                   
               
               
                  193 
                  367 
                 CGACCUCUCCUGCUUCUGCUG 
                 1611 
                 GCAGAAGCAGGAGAGGUCGCA 
                 65.7 
                 64.7 
               
               
                   
               
               
                  194 
                  368 
                 GACCUCUCCUGCUUCUGCUGC 
                 1612 
                 AGCAGAAGCAGGAGAGGUCGC 
                 69.2 
                 68.2 
               
               
                   
               
               
                  195 
                  369 
                 ACCUCUCCUGCUUCUGCUGCU 
                 1613 
                 CAGCAGAAGCAGGAGAGGUCG 
                 65.1 
                 64.1 
               
               
                   
               
               
                  196 
                  370 
                 CCUCUCCUGCUUCUGCUGCUG 
                 1614 
                 GCAGCAGAAGCAGGAGAGGUC 
                 51.7 
                 50.7 
               
               
                   
               
               
                  197 
                  371 
                 CUCUCCUGCUUCUGCUGCUGC 
                 1615 
                 AGCAGCAGAAGCAGGAGAGGU 
                 72.4 
                 71.4 
               
               
                   
               
               
                  198 
                  372 
                 UCUCCUGCUUCUGCUGCUGCC 
                 1616 
                 CAGCAGCAGAAGCAGGAGAGG 
                 62.2 
                 61.2 
               
               
                   
               
               
                  199 
                  373 
                 CUCCUGCUUCUGCUGCUGCCU 
                 1617 
                 GCAGCAGCAGAAGCAGGAGAG 
                 58.2 
                 57.2 
               
               
                   
               
               
                  200 
                  374 
                 UCCUGCUUCUGCUGCUGCCUC 
                 1618 
                 GGCAGCAGCAGAAGCAGGAGA 
                 53.3 
                 51.3 
               
               
                   
               
               
                  201 
                  375 
                 CCUGCUUCUGCUGCUGCCUCU 
                 1619 
                 AGGCAGCAGCAGAAGCAGGAG 
                 71.7 
                 69.7 
               
               
                   
               
               
                  202 
                  376 
                 CUGCUUCUGCUGCUGCCUCUG 
                 1620 
                 GAGGCAGCAGCAGAAGCAGGA 
                 61.5 
                 59.5 
               
               
                   
               
               
                  203 
                  377 
                 UGCUUCUGCUGCUGCCUCUGU 
                 1621 
                 AGAGGCAGCAGCAGAAGCAGG 
                 70 
                 68 
               
               
                   
               
               
                  204 
                  378 
                 GCUUCUGCUGCUGCCUCUGUG 
                 1622 
                 CAGAGGCAGCAGCAGAAGCAG 
                 70.9 
                 68.9 
               
               
                   
               
               
                  205 
                  379 
                 CUUCUGCUGCUGCCUCUGUGU 
                 1623 
                 ACAGAGGCAGCAGCAGAAGCA 
                 68.7 
                 66.7 
               
               
                   
               
               
                  206 
                  380 
                 UUCUGCUGCUGCCUCUGUGUC 
                 1624 
                 CACAGAGGCAGCAGCAGAAGC 
                 50.1 
                 48.1 
               
               
                   
               
               
                  207 
                  381 
                 UCUGCUGCUGCCUCUGUGUCC 
                 1625 
                 ACACAGAGGCAGCAGCAGAAG 
                 69.2 
                 67.2 
               
               
                   
               
               
                  208 
                  382 
                 CUGCUGCUGCCUCUGUGUCCC 
                 1626 
                 GACACAGAGGCAGCAGCAGAA 
                 63.6 
                 61.6 
               
               
                   
               
               
                  209 
                  383 
                 UGCUGCUGCCUCUGUGUCCCG 
                 1627 
                 GGACACAGAGGCAGCAGCAGA 
                 56.7 
                 54.7 
               
               
                   
               
               
                  210 
                  384 
                 GCUGCUGCCUCUGUGUCCCGG 
                 1628 
                 GGGACACAGAGGCAGCAGCAG 
                 63.9 
                 61.9 
               
               
                   
               
               
                  211 
                  385 
                 CUGCUGCCUCUGUGUCCCGGU 
                 1629 
                 CGGGACACAGAGGCAGCAGCA 
                 57 
                 55 
               
               
                   
               
               
                  212 
                  386 
                 UGCUGCCUCUGUGUCCCGGUC 
                 1630 
                 CCGGGACACAGAGGCAGCAGC 
                 44.9 
                 42.9 
               
               
                   
               
               
                  213 
                  387 
                 GCUGCCUCUGUGUCCCGGUCC 
                 1631 
                 ACCGGGACACAGAGGCAGCAG 
                 72.3 
                 70.3 
               
               
                   
               
               
                  214 
                  388 
                 CUGCCUCUGUGUCCCGGUCCU 
                 1632 
                 GACCGGGACACAGAGGCAGCA 
                 61.9 
                 59.9 
               
               
                   
               
               
                  215 
                  389 
                 UGCCUCUGUGUCCCGGUCCUG 
                 1633 
                 GGACCGGGACACAGAGGCAGC 
                 42.8 
                 40.8 
               
               
                   
               
               
                  216 
                  390 
                 GCCUCUGUGUCCCGGUCCUGG 
                 1834 
                 AGGACCGGGACACAGAGGCAG 
                 80.1 
                 78.1 
               
               
                   
               
               
                  217 
                  391 
                 CCUCUGUGUCCCGGUCCUGGU 
                 1635 
                 CAGGACCGGGACACAGAGGCA 
                 64.8 
                 62.8 
               
               
                   
               
               
                  218 
                  392 
                 CUCUGUGUCCCGGUCCUGGUC 
                 1636 
                 CCAGGACCGGGACACAGAGGC 
                 52.1 
                 50.1 
               
               
                   
               
               
                  219 
                  393 
                 UCUGUGUCCCGGUCCUGGUCC 
                 1637 
                 ACCAGGACCGGGACACAGAGG 
                 68.4 
                 66.4 
               
               
                   
               
               
                  220 
                  394 
                 CUGUGUCCCGGUCCUGGUCCC 
                 1638 
                 GACCAGGACCGGGACACAGAG 
                 64.9 
                 62.9 
               
               
                   
               
               
                  221 
                  395 
                 UGUGUCCCGGUCCUGGUCCCG 
                 1639 
                 GGACCAGGACCGGGACACAGA 
                 47.6 
                 45.6 
               
               
                   
               
               
                  222 
                  396 
                 GUGUCCCGGUCCUGGUCCCGG 
                 1640 
                 GGGACCAGGACCGGGACACAG 
                 58.5 
                 56.5 
               
               
                   
               
               
                  223 
                  397 
                 UGUCCCGGUCCUGGUCCCGGA 
                 1641 
                 CGGGACCAGGACCGGGACACA 
                 44.1 
                 42.1 
               
               
                   
               
               
                  224 
                  398 
                 GUCCCGGUCCUGGUCCCGGAC 
                 1642 
                 CCGGGACCAGGACCGGGACAC 
                 43.7 
                 41.7 
               
               
                   
               
               
                  225 
                  399 
                 UCCCGGUCCUGGUCCCGGACC 
                 1643 
                 UCCGGGACCAGGACCGGGACA 
                 66.8 
                 64.8 
               
               
                   
               
               
                  226 
                  400 
                 CCCGGUCCUGGUCCCGGACGC 
                 1644 
                 GUCCGGGACCAGGACCGGGAC 
                 55.5 
                 53.5 
               
               
                   
               
               
                  227 
                  401 
                 CCGGUCCUGGUCCCGGACCCG 
                 1645 
                 GGUCCGGGACCAGGACCGGGA 
                 52.4 
                 50.4 
               
               
                   
               
               
                  228 
                  402 
                 CGGUCCUGGUCCCGGACCCGG 
                 1646 
                 GGGUCCGGGACCAGGACCGGG 
                 62.9 
                 60.9 
               
               
                   
               
               
                  229 
                  403 
                 GGUCCUGGUCCCGGACCCGGG 
                 1647 
                 CGGGUCCGGGACCAGGACCGG 
                 63.3 
                 61.3 
               
               
                   
               
               
                  230 
                  404 
                 GUCCUGGUCCCGGACCCGGGA 
                 1648 
                 CCGGGUCCGGGACCAGGACCG 
                 52.1 
                 50.1 
               
               
                   
               
               
                  231 
                  405 
                 UCCUGGUCCCGGACCCGGGAG 
                 1649 
                 CCCGGGUCCGGGACCAGGACC 
                 39 
                 37 
               
               
                   
               
               
                  232 
                  406 
                 CCUGGUCCCGGACCCGGGAGC 
                 1650 
                 UCCCGGGUCCGGGACCAGGAC 
                 65.8 
                 63.8 
               
               
                   
               
               
                  233 
                  407 
                 CUGGUCCCGGACCCGGGAGCG 
                 1651 
                 CUCCCGGGUCCGGGACCAGGA 
                 51.2 
                 49.2 
               
               
                   
               
               
                  234 
                  408 
                 UGGUCCCGGACCGGGGAGCGA 
                 1652 
                 GCUCCCGGGUCCGGGACCAGG 
                 44.1 
                 42.1 
               
               
                   
               
               
                  235 
                  409 
                 GGUCCCGGACCCGGGAGCGAG 
                 1653 
                 CGCUCCCGGGUCCGGGACCAG 
                 53.4 
                 51.4 
               
               
                   
               
               
                  236 
                  410 
                 GUCCCGGACCCGGGAGCGAGG 
                 1654 
                 UCGCUCCCGGGUCCGGGACCA 
                 68.1 
                 66.1 
               
               
                   
               
               
                  237 
                  411 
                 UCCCGGACCCGGGAGCGAGGC 
                 1655 
                 CUCGCUCCCGGGUCCGGGACG 
                 42.9 
                 40.9 
               
               
                   
               
               
                  238 
                  412 
                 CGCGGACCGGGGAGCGAGGCA 
                 1656 
                 CCUCGCUCCGGGGUCCGGGAC 
                 52 
                 50 
               
               
                   
               
               
                  239 
                  413 
                 CCGGACCCGGGAGCGAGGCAA 
                 1657 
                 GCCUCGCUCCCGGGUCCGGGA 
                 46.6 
                 44.6 
               
               
                   
               
               
                  240 
                  414 
                 CGGACCCGGGAGCGAGGCAAA 
                 1658 
                 UGCCUCGCUCCCGGGUCCGGG 
                 74.7 
                 72.7 
               
               
                   
               
               
                  241 
                  415 
                 GGACCCGGGAGCGAGGCAAAG 
                 1659 
                 UUGCCUCGCUCCCGGGUCCGG 
                 83.5 
                 81.5 
               
               
                   
               
               
                  242 
                  416 
                 GACCCGGGAGCGAGGCAAAGG 
                 1660 
                 UUUGCCUCGCUCCCGGGUCCG 
                 84.7 
                 82.7 
               
               
                   
               
               
                  243 
                  417 
                 ACCCGGGAGCGAGGCAAAGGU 
                 1661 
                 CUUUGCCUCGCUCCCGGGUCC 
                 51.8 
                 49.8 
               
               
                   
               
               
                  244 
                  418 
                 CCCGGGAGCGAGGCAAAGGUC 
                 1662 
                 CCUUUGCCUCGCUCCCGGGUC 
                 52.1 
                 50.1 
               
               
                   
               
               
                  245 
                  419 
                 CCGGGAGCGAGGCAAAGGUCA 
                 1663 
                 ACCUUUGCCUCGCUCCCGGGU 
                 73.1 
                 71.1 
               
               
                   
               
               
                  246 
                  420 
                 CGGGAGCGAGGCAAAGGUCAC 
                 1664 
                 GACCUUUGCCUCGCUCCCGGG 
                 71.1 
                 69.1 
               
               
                   
               
               
                  247 
                  421 
                 GGGAGCGAGGCAAAGGUCACC 
                 1665 
                 UGACCUUUGCCUCGCUCCCGG 
                 86.2 
                 84.2 
               
               
                   
               
               
                  248 
                  422 
                 GGAGCGAGGCAAAGGUCACCC 
                 1666 
                 GUGACCUUUGCCUCGCUCCCG 
                 78.9 
                 76.9 
               
               
                   
               
               
                  249 
                  423 
                 GAGCGAGGCAAAGGUCACCCG 
                 1667 
                 GGUGACCUUUGCCUCGCUCCC 
                 54.4 
                 52.4 
               
               
                   
               
               
                  250 
                  424 
                 AGCGAGGCAAAGGUCACCCGG 
                 1668 
                 GGGUGACCUUUGCCUCGCUCC 
                 46.1 
                 44.1 
               
               
                   
               
               
                  251 
                  425 
                 GCGAGGCAAAGGUCACCCGGA 
                 1669 
                 CGGGUGACCUUUGCCUCGCUC 
                 62.4 
                 60.4 
               
               
                   
               
               
                  252 
                  426 
                 CGAGGCAAAGGUCACCCGGAG 
                 1670 
                 CCGGGUGACCUUUGCCUCGCU 
                 63.5 
                 61.5 
               
               
                   
               
               
                  253 
                  427 
                 GAGGCAAAGGUCACGCGGAGU 
                 1671 
                 UCCGGGUGACCUUUGCCUCGC 
                 73.7 
                 71.7 
               
               
                   
               
               
                  254 
                  428 
                 AGGCAAAGGUCACCCGGAGUU 
                 1672 
                 CUCCGGGUGACCUUUGCCUCG 
                 66.8 
                 64.8 
               
               
                   
               
               
                  255 
                  429 
                 GGCAAAGGUCACCCGGAGUUG 
                 1673 
                 ACUCCGGGUGACCUUUGCCUC 
                 72.3 
                 70.3 
               
               
                   
               
               
                  256 
                  430 
                 GCAAAGGUCACCCGGAGUUGU 
                 1674 
                 AACUCCGGGUGACCUUUGCCU 
                 78.7 
                 76.7 
               
               
                   
               
               
                  257 
                  431 
                 CAAAGGUCACCCGGAGUUGUG 
                 1675 
                 CAACUCCGGGUGACCUUUGCC 
                 61.8 
                 59.8 
               
               
                   
               
               
                  258 
                  432 
                 AAAGGUCACCCGGAGUUGUGC 
                 1676 
                 ACAACUCCGGGUGACCUUUGC 
                 66.6 
                 64.6 
               
               
                   
               
               
                  259 
                  433 
                 AAGGUCACCCGGAGUUGUGCA 
                 1677 
                 CACAACUCCGGGUGACCUUUG 
                 66.7 
                 64.7 
               
               
                   
               
               
                  260 
                  434 
                 AGGUCACCCGGAGUUGUGCAG 
                 1678 
                 GCACAACUCCGGGUGACCUUU 
                 61 
                 59 
               
               
                   
               
               
                  261 
                  435 
                 GGUCACCCGGAGUUGUGCAGA 
                 1679 
                 UGCACAACUCCGGGUGACCUU 
                 84.8 
                 82.8 
               
               
                   
               
               
                  262 
                  436 
                 GUCACCCGGAGUUGUGCAGAG 
                 1680 
                 CUGCACAACUCCGGGUGACCU 
                 64.1 
                 62.1 
               
               
                   
               
               
                  263 
                  437 
                 UCACCCGGAGUUGUGCAGAGA 
                 1681 
                 UCUGCACAACUCCGGGUGACC 
                 58.4 
                 56.4 
               
               
                   
               
               
                  264 
                  438 
                 CACCCGGAGUUGUGCAGAGAC 
                 1682 
                 CUCUGCACAACUCCGGGUGAC 
                 68 
                 66 
               
               
                   
               
               
                  265 
                  439 
                 ACCGGGAGUUGUGCAGAGACC 
                 1683 
                 UCUCUGCACAACUCCGGGUGA 
                 82.6 
                 80.6 
               
               
                   
               
               
                  266 
                  440 
                 CCCGGAGUUGUGCAGAGACCC 
                 1684 
                 GUCUCUGCACAACUCCGGGUG 
                 76.4 
                 74.4 
               
               
                   
               
               
                  267 
                  441 
                 CCGGAGUUGUGCAGAGACCCG 
                 1685 
                 GGUCUCUGCACAACUCCGGGU 
                 74.4 
                 72.4 
               
               
                   
               
               
                  268 
                  442 
                 CGGAGUUGUGCAGAGACCCGG 
                 1686 
                 GGGUCUCUGCACAACUCCGGG 
                 71.9 
                 69.9 
               
               
                   
               
               
                  269 
                  443 
                 GGAGUUGUGCAGAGACCCGGC 
                 1687 
                 CGGGUCUCUGCACAACUCCGG 
                 78 
                 76 
               
               
                   
               
               
                  270 
                  444 
                 GAGUUGUGCAGAGACCCGGCA 
                 1688 
                 CCGGGUCUCUGCACAACUCCG 
                 68.1 
                 66.1 
               
               
                   
               
               
                  271 
                  445 
                 AGUUGUGCAGAGACCCGGCAG 
                 1689 
                 GCCGGGUCUCUGCACAACUCC 
                 56.7 
                 54.7 
               
               
                   
               
               
                  272 
                  446 
                 GUUGUGCAGAGACCCGGCAGG 
                 1690 
                 UGCCGGGUCUCUGCACAACUC 
                 74.1 
                 72.1 
               
               
                   
               
               
                  273 
                  447 
                 UUGUGCAGAGACCCGGCAGGU 
                 1691 
                 CUGCCGGGUCUCUGCACAACU 
                 52.6 
                 50.6 
               
               
                   
               
               
                  274 
                  448 
                 UGUGCAGAGACCCGGCAGGUG 
                 1692 
                 CCUGCCGGGUCUCUGCACAAC 
                 51 
                 49 
               
               
                   
               
               
                  275 
                  449 
                 GUGCAGAGACCCGGCAGGUGC 
                 1693 
                 ACCUGCCGGGUCUCUGCACAA 
                 66.8 
                 64.8 
               
               
                   
               
               
                  276 
                  450 
                 UGCAGAGACCCGGCAGGUGCU 
                 1694 
                 CACCUGCCGGGUCUCUGCACA 
                 54.8 
                 52.8 
               
               
                   
               
               
                  277 
                  451 
                 GCAGAGACCCGGCAGGUGCUG 
                 1695 
                 GCACCUGCCGGGUCUCUGCAC 
                 60 
                 58 
               
               
                   
               
               
                  278 
                  452 
                 CAGAGACCCGGCAGGUGCUGG 
                 1696 
                 AGCACCUGCCGGGUCUCUGCA 
                 71.4 
                 69.4 
               
               
                   
               
               
                  279 
                  453 
                 AGAGACCCGGCAGGUGCUGGG 
                 1697 
                 CAGCACCUGCCGGGUCUCUGC 
                 53.8 
                 51.8 
               
               
                   
               
               
                  306 
                  454 
                 GGGAUAUAGCUUAAACCUAAU 
                 1698 
                 UAGGUUUAAGCUAUAUCCCCG 
                 94.2 
                 91.2 
               
               
                   
               
               
                  307 
                  455 
                 GGAUAUAGCUUAAACCUAAUC 
                 1699 
                 UUAGGUUUAAGCUAUAUCCCC 
                 94.4 
                 91.4 
               
               
                   
               
               
                  308 
                  456 
                 GAUAUAGCUUAAACCUAAUCC 
                 1700 
                 AUUAGGUUUAAGCUAUAUCCC 
                 82.2 
                 79.2 
               
               
                   
               
               
                  309 
                  457 
                 AUAUAGCUUAAACCUAAUCCC 
                 1701 
                 GAUUAGGUUUAAGCUAUAUCC 
                 53.4 
                 50.4 
               
               
                   
               
               
                  310 
                  458 
                 UAUAGCUUAAACCUAAUCCCU 
                 1702 
                 GGAUUAGGUUUAAGCUAUAUC 
                 44.1 
                 41.1 
               
               
                   
               
               
                  311 
                  459 
                 AUAGCUUAAACCUAAUCCCUC 
                 1703 
                 GGGAUUAGGUUUAAGCUAUAU 
                 55.9 
                 52.9 
               
               
                   
               
               
                  312 
                  460 
                 UAGCUUAAACCUAAUCCCUCC 
                 1704 
                 AGGGAUUAGGUUUAAGCUAUA 
                 66.1 
                 63.1 
               
               
                   
               
               
                  313 
                  461 
                 AGCUUAAACCUAAUCCCUCCC 
                 1705 
                 GAGGGAUUAGGUUUAAGCUAU 
                 63.2 
                 60.2 
               
               
                   
               
               
                  314 
                  462 
                 GCUUAAACCUAAUCCCUCCCG 
                 1706 
                 GGAGGGAUUAGGUUUAAGCUA 
                 68.5 
                 65.5 
               
               
                   
               
               
                  315 
                  463 
                 CUUAAACCUAAUCCCUCCCGC 
                 1707 
                 GGGAGGGAUUAGGUUUAAGCU 
                 50.4 
                 47.4 
               
               
                   
               
               
                  316 
                  464 
                 UUAAACCUAAUCCCUCCCGCC 
                 1708 
                 CGGGAGGGAUUAGGUUUAAGC 
                 32.3 
                 29.3 
               
               
                   
               
               
                  317 
                  465 
                 UAAACCUAAUCCCUCCCGCCC 
                 1709 
                 GCGGGAGGGAUUAGGUUUAAG 
                 43.3 
                 40.3 
               
               
                   
               
               
                  318 
                  466 
                 AAACCUAAUCCCUCCCGCCCU 
                 1710 
                 GGCGGGAGGGAUUAGGUUUAA 
                 46.4 
                 43.4 
               
               
                   
               
               
                  319 
                  467 
                 AACCUAAUCCCUCCCGCCCUG 
                 1711 
                 GGGCGGGAGGGAUUAGGUUUA 
                 45.2 
                 42.2 
               
               
                   
               
               
                  320 
                  468 
                 ACCUAAUCCCUCCCGCCCUGA 
                 1712 
                 AGGGCGGGAGGGAUUAGGUUU 
                 60.8 
                 57.8 
               
               
                   
               
               
                  321 
                  469 
                 CCUAAUCCCUCCCGCCCUGAU 
                 1713 
                 CAGGGCGGGAGGGAUUAGGUU 
                 61.7 
                 58.7 
               
               
                   
               
               
                  322 
                  470 
                 CUAAUCCCUCCCGCCCUGAUC 
                 1714 
                 UCAGGGCGGGAGGGAUUAGGU 
                 60 
                 57 
               
               
                   
               
               
                  323 
                  471 
                 UAAUCCCUCCCGCCCUGAUCU 
                 1715 
                 AUCAGGGCGGGAGGGAUUAGG 
                 58.8 
                 55.8 
               
               
                   
               
               
                  324 
                  472 
                 AAUCCCUCCCGCCCUGAUCUC 
                 1716 
                 GAUCAGGGCGGGAGGGAUUAG 
                 50.2 
                 47.2 
               
               
                   
               
               
                  325 
                  473 
                 AUCCCUCCCGCCCUGAUCUCA 
                 1717 
                 AGAUCAGGGCGGGAGGGAUUA 
                 53.3 
                 50.3 
               
               
                   
               
               
                  326 
                  474 
                 UCCCUCCCGCCCUGAUCUCAG 
                 1718 
                 GAGAUCAGGGCGGGAGGGAUU 
                 45.6 
                 42.6 
               
               
                   
               
               
                  327 
                  475 
                 CCCUCCCGCCCUGAUCUCAGG 
                 1719 
                 UGAGAUCAGGGCGGGAGGGAU 
                 66.5 
                 63.5 
               
               
                   
               
               
                  328 
                  476 
                 CCUCCCGCCCUGAUCUCAGGU 
                 1720 
                 CUGAGAUCAGGGCGGGAGGGA 
                 60.3 
                 57.3 
               
               
                   
               
               
                  329 
                  477 
                 CUCCCGCCCUGAUCUCAGGUG 
                 1721 
                 CCUGAGAUCAGGGCGGGAGGG 
                 58.5 
                 55.5 
               
               
                   
               
               
                  330 
                  478 
                 UCCCGCCCUGAUCUCAGGUGA 
                 1722 
                 ACCUGAGAUCAGGGCGGGAGG 
                 52.3 
                 49.3 
               
               
                   
               
               
                  331 
                  479 
                 CCCGCCCUGAUCUCAGGUGAG 
                 1723 
                 CACCUGAGAUCAGGGCGGGAG 
                 56.8 
                 53.8 
               
               
                   
               
               
                  332 
                  480 
                 CCGCCCUGAUCUCAGGUGAGC 
                 1724 
                 UCACCUGAGAUCAGGGCGGGA 
                 79.4 
                 76.4 
               
               
                   
               
               
                  333 
                  481 
                 CGCCCUGAUCUCAGGUGAGCA 
                 1725 
                 CUCACCUGAGAUCAGGGCGGG 
                 71.1 
                 65.1 
               
               
                   
               
               
                  334 
                  482 
                 GCCCUGAUCUCAGGUGAGCAC 
                 1726 
                 GCUCACCUGAGAUCAGGGCGG 
                 61.6 
                 58.6 
               
               
                   
               
               
                  335 
                  483 
                 CCCUGAUCUCAGGUGAGCACC 
                 1727 
                 UGCUCACCUGAGAUCAGGGCG 
                 76.1 
                 73.1 
               
               
                   
               
               
                  336 
                  484 
                 CCUGAUCUCAGGUGAGCACCU 
                 1728 
                 GUGCUCACCUGAGAUCAGGGC 
                 64.3 
                 61.3 
               
               
                   
               
               
                  337 
                  485 
                 CUGAUCUCAGGUGAGCACCUC 
                 1729 
                 GGUGCUCACCUGAGAUCAGGG 
                 53.9 
                 50.9 
               
               
                   
               
               
                  338 
                  486 
                 UGAUCUCAGGUGAGCACCUCC 
                 1730 
                 AGGUGCUCACCUGAGAUCAGG 
                 70.7 
                 67.7 
               
               
                   
               
               
                  339 
                  487 
                 GAUCUCAGGUGAGCACCUCCG 
                 1731 
                 GAGGUGCUCACCUGAGAUCAG 
                 66.3 
                 63.3 
               
               
                   
               
               
                  340 
                  488 
                 AUCUCAGGUGAGCACCUCCGG 
                 1732 
                 GGAGGUGCUCACCUGAGAUCA 
                 52.6 
                 49.6 
               
               
                   
               
               
                  341 
                  489 
                 UCUCAGGUGAGCACCUCCGGG 
                 1733 
                 CGGAGGUGCUCACCUGAGAUC 
                 49.8 
                 46.8 
               
               
                   
               
               
                  342 
                  490 
                 CUCAGGUGAGCACCUCCGGGU 
                 1734 
                 CCGGAGGUGCUCACCUGAGAU 
                 59.5 
                 56.5 
               
               
                   
               
               
                  343 
                  491 
                 UCAGGUGAGCACCUCCGGGUC 
                 1735 
                 CCCGGAGGUGCUCACCUGAGA 
                 49.4 
                 46.4 
               
               
                   
               
               
                  344 
                  492 
                 CAGGUGAGCACCUCCGGGUCU 
                 1736 
                 ACCCGGAGGUGCUCACCUGAG 
                 67.3 
                 64.3 
               
               
                   
               
               
                  345 
                  493 
                 AGGUGAGCACCUCCGGGUCUG 
                 1737 
                 GACCCGGAGGUGCUCACCUGA 
                 62.4 
                 59.4 
               
               
                   
               
               
                  346 
                  494 
                 GGUGAGCACCUCCGGGUCUGU 
                 1738 
                 AGACCCGGAGGUGCUCACCUG 
                 77.1 
                 74.1 
               
               
                   
               
               
                  347 
                  495 
                 GUGAGCACCUCCGGGUCUGUC 
                 1739 
                 CAGACCCGGAGGUGCUCACCU 
                 57.5 
                 54.5 
               
               
                   
               
               
                  348 
                  496 
                 UGAGCACCUCCGGGUCUGUCC 
                 1740 
                 ACAGACCCGGAGGUGCUCACC 
                 54.7 
                 51.7 
               
               
                   
               
               
                  349 
                  497 
                 GAGCACCUCCGGGUCUGUCCC 
                 1741 
                 GACAGACCCGGAGGUGCUCAC 
                 51.7 
                 48.7 
               
               
                   
               
               
                  368 
                  498 
                 CCCAGGAGUACACCUGCUGUU 
                 1742 
                 CAGCAGGUGUACUCCUGGGGA 
                 69 
                 66 
               
               
                   
               
               
                  369 
                  499 
                 CCAGGAGUACACCUGCUGUUC 
                 1743 
                 ACAGCAGGUGUACUCCUGGGG 
                 80.8 
                 77.8 
               
               
                   
               
               
                  370 
                  500 
                 CAGGAGUACACCUGCUGUUCC 
                 1744 
                 AACAGCAGGUGUACUCCUGGG 
                 87.6 
                 84.6 
               
               
                   
               
               
                  371 
                  501 
                 AGGAGUACACCUGCUGUUCCA 
                 1745 
                 GAACAGCAGGUGUACUCCUGG 
                 71.7 
                 68.7 
               
               
                   
               
               
                  372 
                  502 
                 GGAGUACACCUGCUGUUCCAG 
                 1746 
                 GGAACAGCAGGUGUACUCCUG 
                 74.3 
                 71.3 
               
               
                   
               
               
                  373 
                  503 
                 GAGUACACCUGCUGUUCCAGU 
                 1747 
                 UGGAACAGCAGGUGUACUCCU 
                 87.7 
                 84.7 
               
               
                   
               
               
                  374 
                  504 
                 AGUACACCUGCUGUUCCAGUG 
                 1748 
                 CUGGAACAGCAGGUGUACUCC 
                 59.9 
                 56.9 
               
               
                   
               
               
                  375 
                  505 
                 GUACACCUGCUGUUCCAGUGA 
                 1749 
                 ACUGGAACAGCAGGUGUACUC 
                 67.8 
                 64.8 
               
               
                   
               
               
                  376 
                  506 
                 UACACCUGCUGUUCCAGUGAG 
                 1750 
                 CACUGGAACAGCAGGUGUACU 
                 80.5 
                 57.5 
               
               
                   
               
               
                  377 
                  507 
                 ACACCUGCUGUUCCAGUGAGA 
                 1751 
                 UCACUGGAACAGCAGGUGUAC 
                 75.8 
                 72.8 
               
               
                   
               
               
                  378 
                  508 
                 CACCUGCUGUUCCAGUGAGAC 
                 1752 
                 CUCACUGGAACAGCAGGUGUA 
                 75.7 
                 72.7 
               
               
                   
               
               
                  379 
                  509 
                 ACCUGCUGUUCCAGUGAGACA 
                 1753 
                 UCUCACUGGAACAGCAGGUGU 
                 84.6 
                 81.6 
               
               
                   
               
               
                  380 
                  510 
                 CCUGCUGUUCCAGUGAGACAG 
                 1754 
                 GUCUCACUGGAACAGCAGGUG 
                 72.2 
                 69.2 
               
               
                   
               
               
                  381 
                  511 
                 CUGCUGUUCCAGUGAGACAGA 
                 1755 
                 UGUCUCACUGGAACAGCAGGU 
                 87.7 
                 84.7 
               
               
                   
               
               
                  382 
                  512 
                 UGCUGUUCCAGUGAGACAGAG 
                 1756 
                 CUGUCUCACUGGAACAGCAGG 
                 71.6 
                 68.6 
               
               
                   
               
               
                  383 
                  513 
                 GCUGUUCCAGUGAGACAGAGC 
                 1757 
                 UCUGUCUCACUGGAACAGCAG 
                 93.3 
                 90.3 
               
               
                   
               
               
                  384 
                  514 
                 CUGUUCCAGUGAGACAGAGCA 
                 1758 
                 CUCUGUCUCACUGGAACAGCA 
                 67.6 
                 64.6 
               
               
                   
               
               
                  385 
                  515 
                 UGUUCCAGUGAGACAGAGCAG 
                 1759 
                 GCUCUGUCUCACUGGAACAGC 
                 56 
                 53 
               
               
                   
               
               
                  386 
                  516 
                 GUUCCAGUGAGACAGAGCAGA 
                 1760 
                 UGCUCUGUCUCACUGGAACAG 
                 86.6 
                 83.6 
               
               
                   
               
               
                  387 
                  517 
                 UUCCAGUGAGACAGAGCAGAG 
                 1761 
                 CUGCUCUGUCUCACUGGAACA 
                 59.5 
                 56.5 
               
               
                   
               
               
                  388 
                  518 
                 UCCAGUGAGACAGAGCAGAGG 
                 1762 
                 UCUGCUCUGUCUCACUGGAAC 
                 68.1 
                 65.1 
               
               
                   
               
               
                  389 
                  519 
                 CCAGUGAGACAGAGCAGAGGC 
                 1763 
                 CUCUGCUCUGUCUCACUGGAA 
                 76.1 
                 73.1 
               
               
                   
               
               
                  390 
                  520 
                 CAGUGAGACAGAGCAGAGGCU 
                 1764 
                 CCUCUGCUCUGUCUCACUGGA 
                 68.6 
                 65.6 
               
               
                   
               
               
                  391 
                  521 
                 AGUGAGACAGAGCAGAGGCUG 
                 1765 
                 GCCUCUGCUCUGUCUCACUGG 
                 66.3 
                 63.3 
               
               
                   
               
               
                  392 
                  522 
                 GUGAGACAGAGCAGAGGCUGA 
                 1766 
                 AGCCUCUGCUCUGUCUCACUG 
                 76.9 
                 73.9 
               
               
                   
               
               
                  393 
                  523 
                 UGAGACAGAGCAGAGGCUGAU 
                 1767 
                 CAGCCUCUGCUCUGUCUCACU 
                 57.3 
                 54.3 
               
               
                   
               
               
                  394 
                  524 
                 GAGACAGAGCAGAGGCUGAUC 
                 1768 
                 UCAGCCUCUGCUCUGUCUCAC 
                 82.3 
                 79.3 
               
               
                   
               
               
                  395 
                  525 
                 AGACAGAGCAGAGGCUGAUCA 
                 1769 
                 AUCAGCCUCUGCUCUGUCUCA 
                 78.1 
                 75.1 
               
               
                   
               
               
                  396 
                  526 
                 GAGAGAGGAGAGGCUGAUCAG 
                 1770 
                 GAUCAGCCUCUGCUCUGUCUC 
                 63.4 
                 60.4 
               
               
                   
               
               
                  397 
                  527 
                 ACAGAGCAGAGGCUGAUCAGG 
                 1771 
                 UGAUCAGCCUCUGCUCUGUCU 
                 76.2 
                 73.2 
               
               
                   
               
               
                  398 
                  528 
                 CAGAGCAGAGGCUGAUCAGGG 
                 1772 
                 CUGAUCAGCCUCUGCUCUGUC 
                 67.3 
                 64.3 
               
               
                   
               
               
                  399 
                  529 
                 AGAGCAGAGGCUGAUCAGGGA 
                 1773 
                 CCUGAUCAGCCUCUGCUCUGU 
                 63.1 
                 60.1 
               
               
                   
               
               
                  400 
                  530 
                 GAGCAGAGGCUGAUCAGGGAG 
                 1774 
                 CCCUGAUCAGCCUCUGCUCUG 
                 63.2 
                 59.2 
               
               
                   
               
               
                  401 
                  531 
                 AGCAGAGGCUGAUCAGGGAGA 
                 1775 
                 UCCCUGAUCAGCCUCUGCUCU 
                 78.1 
                 74.1 
               
               
                   
               
               
                  402 
                  532 
                 GCAGAGGCUGAUCAGGGAGAC 
                 1776 
                 CUCCCUGAUCAGCCUCUGCUC 
                 64.2 
                 60.2 
               
               
                   
               
               
                  403 
                  533 
                 CAGAGGCUGAUCAGGGAGACU 
                 1777 
                 UCUCCCUGAUCAGCCUCUGCU 
                 76.1 
                 72.1 
               
               
                   
               
               
                  404 
                  534 
                 AGAGGCUGAUCAGGGAGACUG 
                 1778 
                 GUCUCCCUGAUCAGCCUCUGC 
                 57.2 
                 53.2 
               
               
                   
               
               
                  405 
                  538 
                 GAGGCUGAUCAGGGAGACUGA 
                 1779 
                 AGUCUCCCUGAUCAGCCUCUG 
                 75 
                 71 
               
               
                   
               
               
                  406 
                  536 
                 AGGCUGAUCAGGGAGACUGAG 
                 1780 
                 CAGUCUCCCUGAUCAGCCUCU 
                 61.4 
                 57.4 
               
               
                   
               
               
                  407 
                  537 
                 GGCUGAUCAGGGAGACUGAGG 
                 1781 
                 UCAGUCUCCCUGAUCAGCCUC 
                 85.3 
                 81.3 
               
               
                   
               
               
                  408 
                  538 
                 GCUGAUCAGGGAGACUGAGGC 
                 1782 
                 CUCAGUCUCCCUGAUCAGCCU 
                 68.8 
                 64.8 
               
               
                   
               
               
                  409 
                  539 
                 CUGAUCAGGGAGACUGAGGCC 
                 1783 
                 CCUCAGUCUCCCUGAUCAGCC 
                 47.5 
                 43.5 
               
               
                   
               
               
                  410 
                  540 
                 UGAUCAGGGAGACUGAGGCCA 
                 1784 
                 GCCUCAGUCUCCCUGAUCAGC 
                 45.1 
                 41.1 
               
               
                   
               
               
                  411 
                  541 
                 GAUCAGGGAGACUGAGGCCAC 
                 1785 
                 GGCCUCAGUCUCCCUGAUCAG 
                 57.9 
                 53.9 
               
               
                   
               
               
                  430 
                  542 
                 ACCUUCCGAGGCCUGGUGGAG 
                 1786 
                 CCACCAGGCCUCGGAAGGUGG 
                 51 
                 47 
               
               
                   
               
               
                  431 
                  543 
                 CCUUCCGAGGCCUGGUGGAGG 
                 1787 
                 UCCACCAGGCCUCGGAAGGUG 
                 76.9 
                 72.9 
               
               
                   
               
               
                  432 
                  544 
                 CUUCCGAGGCCUGGUGGAGGA 
                 1788 
                 CUCCACCAGGCCUCGGAAGGU 
                 57.9 
                 53.9 
               
               
                   
               
               
                  433 
                  545 
                 UUCCGAGGCCUGGUGGAGGAC 
                 1789 
                 CCUCCACCAGGCCUCGGAAGG 
                 41.3 
                 37.3 
               
               
                   
               
               
                  434 
                  546 
                 UCCGAGGCCUGGUGGAGGACA 
                 1790 
                 UCCUCCACCAGGCCUCGGAAG 
                 69.1 
                 65.1 
               
               
                   
               
               
                  435 
                  547 
                 CCGAGGCCUGGUGGAGGACAG 
                 1791 
                 GUCCUCCACCAGGCCUCGGAA 
                 58.7 
                 54.7 
               
               
                   
               
               
                  436 
                  548 
                 CGAGGCCUGGUGGAGGACAGC 
                 1792 
                 UGUCCUCCACCAGGCCUCGGA 
                 75.4 
                 71.4 
               
               
                   
               
               
                  437 
                  549 
                 GAGGCCUGGUGGAGGACAGCG 
                 1793 
                 CUGUCCUCCACCAGGCCUCGG 
                 70.8 
                 66.8 
               
               
                   
               
               
                  438 
                  550 
                 AGGCCUGGUGGAGGACAGCGG 
                 1794 
                 GCUGUCCUCCACCAGGCCUCG 
                 53.9 
                 49.9 
               
               
                   
               
               
                  439 
                  551 
                 GGCCUGGUGGAGGACAGCGGC 
                 1795 
                 CGCUGUCCUCCACCAGGCCUC 
                 55.2 
                 51.2 
               
               
                   
               
               
                  440 
                  552 
                 GCCUGGUGGAGGACAGCGGCU 
                 1796 
                 CCGCUGUCCUCCACCAGGCCU 
                 64.3 
                 60.3 
               
               
                   
               
               
                  441 
                  553 
                 CCUGGUGGAGGACAGCGGCUC 
                 1797 
                 GCCGCUGUCCUCCACCAGGCC 
                 53.3 
                 49.3 
               
               
                   
               
               
                  442 
                  554 
                 CUGGUGGAGGACAGCGGCUCC 
                 1798 
                 AGCCGCUGUCCUCCACCAGGC 
                 62 
                 58 
               
               
                   
               
               
                  443 
                  555 
                 UGGUGGAGGACAGCGGCUCCU 
                 1799 
                 GAGCCGCUGUCCUCCACCAGG 
                 58.5 
                 54.5 
               
               
                   
               
               
                  444 
                  556 
                 GGUGGAGGACAGCGGCUCCUU 
                 1800 
                 GGAGCCGCUGUCCUCCACCAG 
                 69.3 
                 65.3 
               
               
                   
               
               
                  445 
                  557 
                 GUGGAGGACAGCGGCUCCUUU 
                 1801 
                 AGGAGCCGCUGUCCUCCACCA 
                 65.8 
                 61.8 
               
               
                   
               
               
                  446 
                  558 
                 UGGAGGACAGCGGCUCCUUUC 
                 1802 
                 AAGGAGCCGCUGUCCUCCACC 
                 60.1 
                 56.1 
               
               
                   
               
               
                  447 
                  559 
                 GGAGGACAGCGGCUCCUUUCU 
                 1803 
                 AAAGGAGCCGCUGUCCUCCAC 
                 78.3 
                 74.3 
               
               
                   
               
               
                  448 
                  560 
                 GAGGACAGCGGCUCCUUUCUG 
                 1804 
                 GAAAGGAGCCGCUGUCCUCCA 
                 64.8 
                 60.8 
               
               
                   
               
               
                  449 
                  561 
                 AGGACAGCGGCUCCUUUCUGG 
                 1805 
                 AGAAAGGAGCCGCUGUCCUCC 
                 65.2 
                 61.2 
               
               
                   
               
               
                  450 
                  562 
                 GGACAGCGGCUCCUUUCUGGU 
                 1806 
                 CAGAAAGGAGCCGCUGUCCUC 
                 68.1 
                 64.1 
               
               
                   
               
               
                  451 
                  563 
                 GACAGCGGCUCCUUUCUGGUU 
                 1807 
                 CCAGAAAGGAGCCGCUGUCCU 
                 60 
                 56 
               
               
                   
               
               
                  452 
                  564 
                 ACAGCGGCUCCUUUCUGGUUC 
                 1808 
                 ACCAGAAAGGAGCCGCUGUCC 
                 59.5 
                 55.5 
               
               
                   
               
               
                  453 
                  565 
                 CAGCGGCUCCUUUCUGGUUCA 
                 1809 
                 AACCAGAAAGGAGCCGCUGUC 
                 73.3 
                 69.3 
               
               
                   
               
               
                  454 
                  566 
                 AGCGGCUCCUUUCUGGUUCAC 
                 1810 
                 GAACCAGAAAGGAGCCGCUGU 
                 64 
                 60 
               
               
                   
               
               
                  455 
                  567 
                 GCGGCUCCUUUCUGGUUCACA 
                 1811 
                 UGAACCAGAAAGGAGCCGCUG 
                 91.7 
                 87.7 
               
               
                   
               
               
                  456 
                  568 
                 CGGCUCCUUUCUGGUUCACAC 
                 1812 
                 GUGAACCAGAAAGGAGCCGCU 
                 65.8 
                 61.8 
               
               
                   
               
               
                  457 
                  569 
                 GGCUCCUUUCUGGUUCACACA 
                 1813 
                 UGUGAACCAGAAAGGAGCCGC 
                 74.9 
                 70.9 
               
               
                   
               
               
                  458 
                  570 
                 GCUCCUUUCUGGUUCACACAC 
                 1814 
                 GUGUGAACCAGAAAGGAGCCG 
                 77.6 
                 73.6 
               
               
                   
               
               
                  511 
                  571 
                 UUUCUGGAGAUGCUCUCAGUA 
                 1815 
                 CUGAGAGCAUCUCCAGAAAAA 
                 56 
                 51 
               
               
                   
               
               
                  512 
                  572 
                 UUCUGGAGAUGCUCUCAGUAG 
                 1816 
                 ACUGAGAGCAUCUCCAGAAAA 
                 69.8 
                 64.8 
               
               
                   
               
               
                  513 
                  573 
                 UCUGGAGAUGCUCUCAGUAGC 
                 1817 
                 UACUGAGAGCAUCUCCAGAAA 
                 80.1 
                 75.1 
               
               
                   
               
               
                  514 
                  574 
                 CUGGAGAUGCUCUCAGUAGCC 
                 1818 
                 CUACUGAGAGCAUCUCCAGAA 
                 73.2 
                 65.2 
               
               
                   
               
               
                  515 
                  575 
                 UGGAGAUGCUCUCAGUAGCCC 
                 1819 
                 GCUACUGAGAGCAUCUCCAGA 
                 68.1 
                 63.1 
               
               
                   
               
               
                  516 
                  576 
                 GGAGAUGCUCUCAGUAGCCCA 
                 1820 
                 GGCUACUGAGAGCAUCUCCAG 
                 70.2 
                 65.2 
               
               
                   
               
               
                  517 
                  577 
                 GAGAUGCUCUCAGUAGCCCAG 
                 1821 
                 GGGCUACUGAGAGCAUCUCCA 
                 58.2 
                 53.2 
               
               
                   
               
               
                  518 
                  578 
                 AGAUGCUCUCAGUAGCCCAGC 
                 1822 
                 UGGGCUACUGAGAGCAUCUCC 
                 74.7 
                 69.7 
               
               
                   
               
               
                  519 
                  579 
                 GAUGeUCUCAGUAGCCCAGCA 
                 1823 
                 CUGGGCUACUGAGAGCAUCUC 
                 67.4 
                 62.4 
               
               
                   
               
               
                  520 
                  580 
                 AUGCUCUCAGUAGCCCAGCAC 
                 1824 
                 GCUGGGCUACUGAGAGCAUCU 
                 42.6 
                 37.6 
               
               
                   
               
               
                  521 
                  581 
                 UGCUCUCAGUAGCCCAGCACU 
                 1825 
                 UGCUGGGCUACUGAGAGCAUC 
                 71.1 
                 66.1 
               
               
                   
               
               
                  522 
                  582 
                 GCUCUCAGUAGCCCAGCACUC 
                 1826 
                 GUGCUGGGCUACUGAGAGCAU 
                 65.2 
                 60.2 
               
               
                   
               
               
                  523 
                  583 
                 CUCUCAGUAGCCCAGCACUCU 
                 1827 
                 AGUGCUGGGCUACUGAGAGCA 
                 69.1 
                 64.1 
               
               
                   
               
               
                  524 
                  584 
                 UCUCAGUAGCCCAGCACUCUC 
                 1828 
                 GAGUGCUGGGCUACUGAGAGC 
                 53.9 
                 48.9 
               
               
                   
               
               
                  525 
                  585 
                 CUCAGUAGCCCAGCACUCUCU 
                 1829 
                 AGAGUGCUGGGCUACUGAGAG 
                 68.6 
                 63.6 
               
               
                   
               
               
                  526 
                  586 
                 UCAGUAGCCCAGCACUCUCUG 
                 1830 
                 GAGAGUGCUGGGCUACUGAGA 
                 60.6 
                 55.6 
               
               
                   
               
               
                  527 
                  587 
                 CAGUAGCCCAGCACUCUCUGA 
                 1831 
                 AGAGAGUGCUGGGCUACUGAG 
                 74 
                 69 
               
               
                   
               
               
                  528 
                  588 
                 AGUAGCCCAGCACUCUCUGAC 
                 1832 
                 CAGAGAGUGCUGGGCUACUGA 
                 62.6 
                 57.6 
               
               
                   
               
               
                  529 
                  589 
                 GUAGaCCAGCACUCUCUGACC 
                 1833 
                 UCAGAGAGUGCUGGGCUACUG 
                 77.9 
                 72.9 
               
               
                   
               
               
                  530 
                  590 
                 UAGCCCAGCACUCUCUGACCC 
                 1834 
                 GUCAGAGAGUGCUGGGCUACU 
                 47.4 
                 42.4 
               
               
                   
               
               
                  531 
                  591 
                 AGCCCAGCACUCUCUGACCCA 
                 1835 
                 GGUCAGAGAGUGCUGGGCUAC 
                 51.1 
                 46.1 
               
               
                   
               
               
                  532 
                  592 
                 GCCCAGCACUCUCUGACCCAG 
                 1836 
                 GGGUCAGAGAGUGCUGGGCUA 
                 59.9 
                 54.9 
               
               
                   
               
               
                  533 
                  593 
                 CeCAGCACUCUCUGACCCAGC 
                 1837 
                 UGGGUCAGAGAGUGCUGGGCU 
                 72.5 
                 67.5 
               
               
                   
               
               
                  534 
                  594 
                 CCAGCACUCUCUGACCCAGCU 
                 1838 
                 CUGGGUCAGAGAGUGCUGGGC 
                 63.9 
                 58.9 
               
               
                   
               
               
                  535 
                  595 
                 CAGCACUCUCUGACCCAGCUC 
                 1839 
                 GCUGGGUCAGAGAGUGCUGGG 
                 60.7 
                 55.7 
               
               
                   
               
               
                  536 
                  596 
                 AGCACUCUCUGACCCAGCUCU 
                 1840 
                 AGCUGGGUCAGAGAGUGCUGG 
                 75.2 
                 70.2 
               
               
                   
               
               
                  537 
                  597 
                 GCACUCUCUGACCCAGCUCUU 
                 1841 
                 GAGCUGGGUCAGAGAGUGCUG 
                 68.6 
                 63.6 
               
               
                   
               
               
                  538 
                  598 
                 CACUCUCUGACCCAGCUCUUC 
                 1842 
                 AGAGCUGGGUCAGAGAGUGCU 
                 71.8 
                 66.8 
               
               
                   
               
               
                  539 
                  599 
                 ACUCUCUGACCCAGCUCUUCU 
                 1843 
                 AAGAGCUGGGUCAGAGAGUGC 
                 68.7 
                 63.7 
               
               
                   
               
               
                  540 
                  600 
                 CUCUCUGACCCAGCUCUUCUC 
                 1844 
                 GAAGAGCUGGGUCAGAGAGUG 
                 64.2 
                 59.2 
               
               
                   
               
               
                  541 
                  601 
                 UCUCUGACCCAGCUCUUCUCC 
                 1845 
                 AGAAGAGCUGGGUCAGAGAGU 
                 64.9 
                 59.9 
               
               
                   
               
               
                  542 
                  602 
                 CUCUGACCCAGCUCUUCUCCC 
                 1846 
                 GAGAAGAGCUGGGUCAGAGAG 
                 66.2 
                 61.2 
               
               
                   
               
               
                  543 
                  603 
                 UCUGACCCAGCUCUUCUCCCA 
                 1847 
                 GGAGAAGAGCUGGGUCAGAGA 
                 45.5 
                 40.5 
               
               
                   
               
               
                  544 
                  604 
                 CUGACCCAGCUCUUCUCCCAC 
                 1848 
                 GGGAGAAGAGCUGGGUCAGAG 
                 51.4 
                 46.4 
               
               
                   
               
               
                  545 
                  605 
                 UGACCCAGCUCUUCUCCCACU 
                 1849 
                 UGGGAGAAGAGCUGGGUCAGA 
                 71.4 
                 66.4 
               
               
                   
               
               
                  546 
                  606 
                 GACCCAGCUCUUCUCCCACUC 
                 1850 
                 GUGGGAGAAGAGCUGGGUCAG 
                 65.7 
                 60.7 
               
               
                   
               
               
                  547 
                  607 
                 ACCCAGCUCUUCUCCCACUCC 
                 1851 
                 AGUGGGAGAAGAGCUGGGUCA 
                 65.4 
                 60.4 
               
               
                   
               
               
                  548 
                  608 
                 CCCAGCUCUUCUCCCACUCCU 
                 1852 
                 GAGUGGGAGAAGAGCUGGGUC 
                 59.1 
                 54.1 
               
               
                   
               
               
                  549 
                  609 
                 CCAGCUCUUCUCCCACUCCUA 
                 1853 
                 GGAGUGGGAGAAGAGCUGGGU 
                 61.4 
                 56.4 
               
               
                   
               
               
                  550 
                  610 
                 CAGCUCUUCUCCCACUCCUAC 
                 1854 
                 AGGAGUGGGAGAAGAGCUGGG 
                 75.9 
                 70.9 
               
               
                   
               
               
                  551 
                  611 
                 AGCUCUUCUCCCACUCCUACG 
                 1855 
                 UAGGAGUGGGAGAAGAGCUGG 
                 90.4 
                 85.4 
               
               
                   
               
               
                  552 
                  612 
                 GCUCUUCUCCCACUCCUACGG 
                 1856 
                 GUAGGAGUGGGAGAAGAGCUG 
                 73 
                 68 
               
               
                   
               
               
                  553 
                  613 
                 CUCUUCUCCCACUCCUACGGC 
                 1857 
                 CGUAGGAGUGGGAGAAGAGCU 
                 57 
                 52 
               
               
                   
               
               
                  554 
                  614 
                 UCUUCUCCCACUCCUACGGCC 
                 1858 
                 CCGUAGGAGUGGGAGAAGAGC 
                 47.7 
                 42.7 
               
               
                   
               
               
                  555 
                  615 
                 CUUCUCCCACUCCUACGGCCG 
                 1859 
                 GCCGUAGGAGUGGGAGAAGAG 
                 45.1 
                 43.1 
               
               
                   
               
               
                  556 
                  616 
                 UUCUCCCACUCCUACGGCCGC 
                 1860 
                 GGCCGUAGGAGUGGGAGAAGA 
                 41 
                 36 
               
               
                   
               
               
                  557 
                  617 
                 UCUCCCACUCCUACGGCCGCC 
                 1861 
                 CGGCCGUAGGAGUGGGAGAAG 
                 46.2 
                 41.2 
               
               
                   
               
               
                  558 
                  618 
                 CUCCCACUCCUACGGCCGCCU 
                 1862 
                 GCGGCCGUAGGAGUGGGAGAA 
                 49.9 
                 44.9 
               
               
                   
               
               
                  559 
                  619 
                 UCCCACUCCUACGGCCGCCUG 
                 1863 
                 GGCGGCCGUAGGAGUGGGAGA 
                 36.1 
                 31.1 
               
               
                   
               
               
                  560 
                  620 
                 CCCACUCCUACGGCCGCCUGU 
                 1864 
                 AGGCGGCCGUAGGAGUGGGAG 
                 59.3 
                 54.3 
               
               
                   
               
               
                  561 
                  621 
                 CCACUCCUACGGCCGCCUGUA 
                 1865 
                 CAGGCGGCCGUAGGAGUGGGA 
                 58.7 
                 53.7 
               
               
                   
               
               
                  562 
                  622 
                 CACUCCUACGGCCGCCUGUAU 
                 1866 
                 ACAGGCGGCCGUAGGAGUGGG 
                 68.9 
                 63.9 
               
               
                   
               
               
                  563 
                  623 
                 ACUCCUACGGCCGCCUGUAUG 
                 1867 
                 UACAGGCGGCCGUAGGAGUGG 
                 75.5 
                 70.5 
               
               
                   
               
               
                  564 
                  624 
                 CUCCUACGGCCGCCUGUAUGC 
                 1868 
                 AUACAGGCGGCCGUAGGAGUG 
                 74.2 
                 69.2 
               
               
                   
               
               
                  565 
                  625 
                 UCCUACGGCCGCCUGUAUGCC 
                 1869 
                 CAUACAGGCGGCCGUAGGAGU 
                 51.9 
                 46.9 
               
               
                   
               
               
                  566 
                  626 
                 CCUACGGCCGCCUGUAUGCCC 
                 1870 
                 GCAUACAGGCGGCCGUAGGAG 
                 58.8 
                 53.8 
               
               
                   
               
               
                  567 
                  627 
                 CUACGGCCGCCUGUAUGCCCA 
                 1871 
                 GGCAUACAGGCGGCCGUAGGA 
                 46.7 
                 41.7 
               
               
                   
               
               
                  568 
                  628 
                 UACGGCCGCCUGUAUGCCCAG 
                 1872 
                 GGGCAUACAGGCGGCCGUAGG 
                 40.1 
                 35.1 
               
               
                   
               
               
                  569 
                  629 
                 ACGGCCGCCUGUAUGCCCAGC 
                 1873 
                 UGGGCAUACAGGCGGCCGUAG 
                 64.8 
                 59.8 
               
               
                   
               
               
                  570 
                  630 
                 CGGCCGCCUGUAUGCCCAGCA 
                 1874 
                 CUGGGCAUACAGGCGGCCGUA 
                 63.9 
                 58.9 
               
               
                   
               
               
                  571 
                  631 
                 GGCCGCCUGUAUGCCCAGCAC 
                 1875 
                 GCUGGGCAUACAGGCGGCCGU 
                 52.4 
                 47.4 
               
               
                   
               
               
                  572 
                  632 
                 GCCGCCUGUAUGCCCAGCACG 
                 1876 
                 UGCUGGGCAUACAGGCGGCCG 
                 69 
                 64 
               
               
                   
               
               
                  573 
                  633 
                 CCGCCUGUAUGCCCAGCACGC 
                 1877 
                 GUGCUGGGCAUACAGGCGGCC 
                 58.6 
                 53.6 
               
               
                   
               
               
                  574 
                  634 
                 CGCCUGUAUGCCCAGCACGCC 
                 1878 
                 CGUGCUGGGCAUACAGGCGGC 
                 57.2 
                 52.2 
               
               
                   
               
               
                  575 
                  635 
                 GCCUGUAUGCCCAGCACGCCC 
                 1879 
                 GCGUGCUGGGCAUACAGGCGG 
                 63.6 
                 58.6 
               
               
                   
               
               
                  576 
                  636 
                 CCUGUAUGCCCAGCACGCCCU 
                 1880 
                 GGCGUGCUGGGCAUACAGGCG 
                 51.2 
                 46.2 
               
               
                   
               
               
                  577 
                  637 
                 CUGUAUGCCCAGCACGCCCUC 
                 1881 
                 GGGCGUGCUGGGCAUACAGGC 
                 47.4 
                 42.4 
               
               
                   
               
               
                  578 
                  638 
                 UGUAUGCCCAGCACGCCCUCA 
                 1882 
                 AGGGCGUGCUGGGCAUACAGG 
                 58.9 
                 53.9 
               
               
                   
               
               
                  579 
                  639 
                 GUAUGCCCAGCACGCCCUCAU 
                 1883 
                 GAGGGCGUGCUGGGCAUACAG 
                 54.8 
                 49.8 
               
               
                   
               
               
                  580 
                  640 
                 UAUGCCCAGCACGCCCUCAUA 
                 1884 
                 UGAGGGCGUGCUGGGCAUACA 
                 53.9 
                 48.9 
               
               
                   
               
               
                  581 
                  641 
                 AUGCCCAGCACGCCCUCAUAU 
                 1885 
                 AUGAGGGCGUGCUGGGCAUAC 
                 54 
                 49 
               
               
                   
               
               
                  582 
                  642 
                 UGCCCAGCACGCCCUCAUAUU 
                 1886 
                 UAUGAGGGCGUGCUGGGCAUA 
                 74.3 
                 69.3 
               
               
                   
               
               
                  583 
                  643 
                 GCCCAGCACGCCCUCAUAUUC 
                 1887 
                 AUAUGAGGGCGUGCUGGGCAU 
                 72.6 
                 67.6 
               
               
                   
               
               
                  584 
                  644 
                 CCCAGCACGCCCUCAUAUUCA 
                 1888 
                 AAUAUGAGGGCGUGCUGGGCA 
                 70.8 
                 65.8 
               
               
                   
               
               
                  585 
                  645 
                 CCAGCACGCCCUCAUAUUCAA 
                 1889 
                 GAAUAUGAGGGCGUGCUGGGC 
                 61.5 
                 56.5 
               
               
                   
               
               
                  586 
                  646 
                 CAGCACGCCCUCAUAUUCAAU 
                 1890 
                 UGAAUAUGAGGGCGUGCUGGG 
                 77.4 
                 72.4 
               
               
                   
               
               
                  587 
                  647 
                 AGCACGCCCUCAUAUUCAAUG 
                 1891 
                 UUGAAUAUGAGGGCGUGCUGG 
                 91.7 
                 86.7 
               
               
                   
               
               
                  588 
                  648 
                 GCACGCCCUCAUAUUCAAUGG 
                 1892 
                 AUUGAAUAUGAGGGCGUGCUG 
                 81.4 
                 76.4 
               
               
                   
               
               
                  607 
                  649 
                 GGCCUGUUCUCUCGGCUGCGA 
                 1893 
                 GCAGCCGAGAGAACAGGCCAU 
                 66.3 
                 60.3 
               
               
                   
               
               
                  608 
                  650 
                 GCCUGUUCUCUCGGCUGCGAG 
                 1894 
                 CGCAGCCGAGAGAACAGGCCA 
                 61.2 
                 55.2 
               
               
                   
               
               
                  609 
                  651 
                 CCUGUUCUCUCGGCUGCGAGA 
                 1895 
                 UCGCAGCCGAGAGAACAGGCC 
                 74.9 
                 68.9 
               
               
                   
               
               
                  610 
                  652 
                 CUGUUCUCUCGGCUGCGAGAC 
                 1896 
                 CUCGCAGCCGAGAGAACAGGC 
                 59.5 
                 53.5 
               
               
                   
               
               
                  611 
                  653 
                 UGUUCUCUCGGCUGCGAGACU 
                 1897 
                 UCUCGCAGCCGAGAGAACAGG 
                 12.9 
                 76.9 
               
               
                   
               
               
                  612 
                  654 
                 GUUCUCUCGGCUGCGAGACUU 
                 1898 
                 GUCUCGCAGCCGAGAGAACAG 
                 61.6 
                 55.6 
               
               
                   
               
               
                  613 
                  655 
                 UUCUCUCGGCUGCGAGACUUC 
                 1899 
                 AGUCUCGCAGCCGAGAGAACA 
                 60.5 
                 54.5 
               
               
                   
               
               
                  614 
                  656 
                 UCUCUCGGCUGCGAGACUUCU 
                 1900 
                 AAGUCUCGCAGCCGAGAGAAC 
                 61.9 
                 55.9 
               
               
                   
               
               
                  615 
                  657 
                 CUCUCGGCUGCGAGACUUCUA 
                 1901 
                 GAAGUCUCGCAGCCGAGAGAA 
                 67.9 
                 61.9 
               
               
                   
               
               
                  616 
                  658 
                 UCUCGGCUGCGAGACUUCUAU 
                 1902 
                 AGAAGUCUCGCAGCCGAGAGA 
                 69.2 
                 63.2 
               
               
                   
               
               
                  617 
                  659 
                 CUCGGCUGCGAGACUUCUAUG 
                 1903 
                 UAGAAGUCUCGCAGCCGAGAG 
                 88.9 
                 82.9 
               
               
                   
               
               
                  618 
                  660 
                 UCGGCUGCGAGACUUCUAUGG 
                 1904 
                 AUAGAAGUCUCGCAGCCGAGA 
                 76.5 
                 70.5 
               
               
                   
               
               
                  619 
                  661 
                 CGGCUCCGAGACUUCUAUGGG 
                 1905 
                 CAUAGAAGUCUCGCAGCCGAG 
                 79.7 
                 73.7 
               
               
                   
               
               
                  669 
                  662 
                 GGCGGAUUUCUGGGCACAGCU 
                 1906 
                 CUGUGCCCAGAAAUCCGCCAG 
                 69 
                 63 
               
               
                   
               
               
                  670 
                  663 
                 GCGGAUUUCUGGGCACAGCUC 
                 1007 
                 GCUGUGCCCAGAAAUCCGCCA 
                 60 
                 54 
               
               
                   
               
               
                  671 
                  664 
                 CGGAUUUCUGGGCACAGCUCC 
                 1908 
                 AGCUGUGCCCAGAAAUCCGCC 
                 66.1 
                 60.1 
               
               
                   
               
               
                  672 
                  665 
                 GGAUUUCUGGGCACAGCUCCU 
                 1909 
                 GAGCUGUGCCCAGAAAUCCGC 
                 64.6 
                 58.6 
               
               
                   
               
               
                  673 
                  666 
                 GAUUUCUGGGCACAGCUCCUG 
                 1910 
                 GGAGCUGUGCCCAGAAAUCCG 
                 57.3 
                 51.3 
               
               
                   
               
               
                  674 
                  667 
                 AUUUCUGGGCACAGCUCCUGG 
                 1911 
                 AGGAGCUGUGCCCAGAAAUCC 
                 56 
                 50 
               
               
                   
               
               
                  675 
                  668 
                 UUUCUGGGCACAGCUCCUGGA 
                 1912 
                 CAGGAGCUGUGCCCAGAAAUC 
                 40.1 
                 34.1 
               
               
                   
               
               
                  676 
                  669 
                 UUCUGGGCACAGCUCCUGGAG 
                 1913 
                 CCAGGAGCUGUGCCCAGAAAU 
                 45.7 
                 39.7 
               
               
                   
               
               
                  677 
                  670 
                 UCUGGGCACAGCUCCUGGAGA 
                 1914 
                 UCCAGGAGCUGUGCCCAGAAA 
                 67.2 
                 61.2 
               
               
                   
               
               
                  678 
                  671 
                 CUGGGCACAGCUCCUGGAGAG 
                 1915 
                 CUCCAGGAGCUGUGCCCAGAA 
                 56.6 
                 50.6 
               
               
                   
               
               
                  679 
                  672 
                 UGGGCACAGCUCCUGGAGAGA 
                 1916 
                 UCUCCAGGAGCUGUGCCCAGA 
                 70.5 
                 64.5 
               
               
                   
               
               
                  680 
                  673 
                 GGGCACAGCUCCUGGAGAGAG 
                 1917 
                 CUCUCCAGGAGCUGUGCCCAG 
                 71 
                 65 
               
               
                   
               
               
                  681 
                  674 
                 GGCACAGCUCCUGGAGAGAGU 
                 1918 
                 UCUCUCCAGGAGCUGUGCCCA 
                 81.7 
                 75.7 
               
               
                   
               
               
                  682 
                  675 
                 GCACAGCUCCUGGAGAGAGUG 
                 1919 
                 CUCUCUCCAGGAGCUGUGCCC 
                 62.6 
                 56.6 
               
               
                   
               
               
                  683 
                  676 
                 CACAGCUCCUGGAGAGAGUGU 
                 1920 
                 ACUCUCUCCAGGAGCUGUGCC 
                 69.9 
                 63.9 
               
               
                   
               
               
                  684 
                  677 
                 ACAGCUCCUGGAGAGAGUGUU 
                 1921 
                 CACUCUCUCCAGGAGCUGUGC 
                 59.9 
                 53.9 
               
               
                   
               
               
                  685 
                  678 
                 CAGCUCCUGGAGAGAGUGUUC 
                 1922 
                 ACACUCUCUCCAGGAGCUGUG 
                 78 
                 72 
               
               
                   
               
               
                  686 
                  679 
                 AGCUCCUGGAGAGAGUGUUCC 
                 1923 
                 AACACUCUCUCCAGGAGCUGU 
                 80 
                 74 
               
               
                   
               
               
                  687 
                  680 
                 GCUCCUGGAGAGAGUGUUCCC 
                 1924 
                 GAACACUCUCUCCAGGAGCUG 
                 81.5 
                 75.5 
               
               
                   
               
               
                  688 
                  681 
                 CUCCUGGAGAGAGUGUUCCCG 
                 1925 
                 GGAACACUCUCUCCAGGAGCU 
                 56.5 
                 50.5 
               
               
                   
               
               
                  689 
                  682 
                 UCCUGGAGAGAGUGUUCCCGC 
                 1926 
                 GGGAACACUCUCUCCAGGAGC 
                 54 
                 48 
               
               
                   
               
               
                  690 
                  683 
                 CCUGGAGAGAGUGUUCCCGCU 
                 1927 
                 CGGGAACACUCUCUCCAGGAG 
                 63.8 
                 57.8 
               
               
                   
               
               
                  691 
                  684 
                 CUGGAGAGAGUGUUCCCGCUG 
                 1928 
                 GCGGGAACACUCUCUCCAGGA 
                 59.5 
                 53.5 
               
               
                   
               
               
                  692 
                  685 
                 UGGAGAGAGUGUUCCCGCUGC 
                 1929 
                 AGCGGGAACACUCUCUCCAGG 
                 74.6 
                 68.6 
               
               
                   
               
               
                  693 
                  686 
                 GGAGAGAGUGUUCCCGCUGCU 
                 1930 
                 CAGCGGGAACACUCUCUCCAG 
                 77.3 
                 71.3 
               
               
                   
               
               
                  694 
                  687 
                 GAGAGAGUGUUCCCGCUGCUG 
                 1931 
                 GCAGCGGGAACACUCUCUCCA 
                 67.2 
                 61.2 
               
               
                   
               
               
                  695 
                  688 
                 AGAGAGUGUUCCCGCUGCUGC 
                 1932 
                 AGCAGCGGGAACACUCUCUCC 
                 72.2 
                 66.2 
               
               
                   
               
               
                  696 
                  689 
                 GAGAGUGUUCCCGCUGCUGCA 
                 1933 
                 CAGCAGCGGGAACACUCUCUC 
                 65.7 
                 59.7 
               
               
                   
               
               
                  697 
                  690 
                 AGAGUGUUCCCGCUGCUGCAC 
                 1934 
                 GCAGCAGCGGGAACACUCUCU 
                 61.3 
                 55.3 
               
               
                   
               
               
                  698 
                  691 
                 GAGUGUUCCCGCUGCUGCACC 
                 1935 
                 UGCAGCAGCGGGAACACUCUC 
                 83.8 
                 77.8 
               
               
                   
               
               
                  699 
                  692 
                 AGUGUUCCCGCUGCUGCACCC 
                 1936 
                 GUGCAGCAGCGGGAACACUCU 
                 61.3 
                 66.3 
               
               
                   
               
               
                  700 
                  693 
                 GUGUUCCCGCUGCUGCACCCA 
                 1937 
                 GGUGCAGCAGCGGGAACACUC 
                 49.4 
                 42.4 
               
               
                   
               
               
                  701 
                  694 
                 UGUUCCCGCUGCUGCACCCAC 
                 1938 
                 GGGUGCAGCAGCGGGAACACU 
                 51.7 
                 44.7 
               
               
                   
               
               
                  702 
                  695 
                 GUUCCCGCUGCUGCACCCACA 
                 1939 
                 UGGGUGCAGCAGCGGGAACAC 
                 61.8 
                 54.8 
               
               
                   
               
               
                  703 
                  696 
                 UUCCCGCUGCUGCACCCACAG 
                 1940 
                 GUGGGUGCAGCAGCGGGAACA 
                 47.4 
                 40.4 
               
               
                   
               
               
                  704 
                  697 
                 UCCCGCUGCUGCACCCACAGU 
                 1941 
                 UGUGGGUGCAGCAGCGGGAAC 
                 61.9 
                 54.9 
               
               
                   
               
               
                  705 
                  698 
                 CCCGCUGCUGCACCCACAGUA 
                 1942 
                 CUGUGGGUGCAGCAGCGGGAA 
                 66.2 
                 59.2 
               
               
                   
               
               
                  706 
                  699 
                 CCGCUGCUGCACCCACAGUAC 
                 1943 
                 ACUGUGGGUGCAGCAGCGGGA 
                 74.1 
                 67.1 
               
               
                   
               
               
                  707 
                  700 
                 CGCUGCUGCACCCACAGUACA 
                 1944 
                 UACUGUGGGUGCAGCAGCGGG 
                 89.1 
                 82.1 
               
               
                   
               
               
                  708 
                  701 
                 GCUGCUGCACCCACAGUACAG 
                 1945 
                 GUACUGUGGGUGCAGCAGCGG 
                 77.2 
                 70.2 
               
               
                   
               
               
                  709 
                  702 
                 CUGCUGCACCCACAGUACAGC 
                 1946 
                 UGUACUGUGGGUGCAGCAGCG 
                 81.2 
                 74.2 
               
               
                   
               
               
                  710 
                  703 
                 UGCUGCACCCACAGUACAGCU 
                 1947 
                 CUGUACUGUGGGUGCAGCAGC 
                 58.9 
                 51.9 
               
               
                   
               
               
                  711 
                  704 
                 GCUGCACCCACAGUACAGCUU 
                 1948 
                 GCUGUACUGUGGGUGCAGCAG 
                 61.8 
                 54.8 
               
               
                   
               
               
                  712 
                  705 
                 CUGCACCCACAGUACAGCUUC 
                 1949 
                 AGCUGUACUGUGGGUGCAGCA 
                 67.4 
                 60.4 
               
               
                   
               
               
                  713 
                  706 
                 UGCACCCACAGUACAGCUUCC 
                 1950 
                 AAGCUGUACUGUGGGUGCAGC 
                 64.4 
                 57.4 
               
               
                   
               
               
                  714 
                  707 
                 GCACCCACAGUACAGCUUCCC 
                 1951 
                 GAAGCUGUACUGUGGGUGCAG 
                 71.1 
                 64.1 
               
               
                   
               
               
                  735 
                  708 
                 CCCUGACUACCUGCUCUGCCU 
                 1952 
                 GCAGAGCAGGUAGUCAGGGGG 
                 64.2 
                 57.2 
               
               
                   
               
               
                  736 
                  709 
                 CCUGACUACCUGCUCUGCCUC 
                 1953 
                 GGCAGAGCAGGUAGUCAGGGG 
                 59.7 
                 52.7 
               
               
                   
               
               
                  737 
                  710 
                 CUGACUACCUGCUCUGCCUCU 
                 1954 
                 AGGCAGAGCAGGUAGUCAGGG 
                 76.6 
                 69.8 
               
               
                   
               
               
                  738 
                  711 
                 UGACUACCUGCUCUGCCUCUC 
                 1955 
                 GAGGCAGAGCAGGUAGUCAGG 
                 60.3 
                 53.3 
               
               
                   
               
               
                  739 
                  712 
                 GACUACCUGCUCUGCCUCUCA 
                 1956 
                 AGAGGCAGAGCAGGUAGUCAG 
                 74.4 
                 67.4 
               
               
                   
               
               
                  740 
                  713 
                 ACUACCUGCUCUGCCUCUCAC 
                 1957 
                 GAGAGGCAGAGCAGGUAGUCA 
                 57.9 
                 50.9 
               
               
                   
               
               
                  741 
                  714 
                 CUACCUGCUCUGCCUCUCACG 
                 1958 
                 UGAGAGGCAGAGCAGGUAGUC 
                 74.9 
                 67.9 
               
               
                   
               
               
                  742 
                  715 
                 UACCUGCUCUGCCUCUCACGC 
                 1959 
                 GUGAGAGGCAGAGCAGGUAGU 
                 58.7 
                 51.7 
               
               
                   
               
               
                  743 
                  715 
                 UACCUGCUCUGCCUCUCACGC 
                 1960 
                 CGUGAGAGGCAGAGCAGGUAG 
                 57.9 
                 50.9 
               
               
                   
               
               
                  744 
                  717 
                 CCUGCUCUGCCUCUCACGCUU 
                 1961 
                 GCGUGAGAGGCAGAGCAGGUA 
                 59.9 
                 52.9 
               
               
                   
               
               
                  745 
                  718 
                 CUGCUCUGCCUCUCACGCUUG 
                 1962 
                 AGCGUGAGAGGCAGAGCAGGU 
                 64.7 
                 57.7 
               
               
                   
               
               
                  746 
                  719 
                 UGCUCUGCCUCUCACGCUUGG 
                 1963 
                 AAGCGUGAGAGGCAGAGCAGG 
                 77.1 
                 70.1 
               
               
                   
               
               
                  781 
                  720 
                 GGCUCUCUGCAGCCCUUUGGG 
                 1964 
                 CAAAGGGCUGCAGAGAGCCAU 
                 72.2 
                 65.2 
               
               
                   
               
               
                  809 
                  721 
                 CCCGCCGCCUCCGCCUGCAGA 
                 1965 
                 UGCAGGCGGAGGCGGCGGGGU 
                 60.6 
                 52.6 
               
               
                   
               
               
                  810 
                  722 
                 CCGCCGCCUCCGCCUGCAGAU 
                 1966 
                 CUGCAGGCGGAGGCGGCGGGG 
                 59.5 
                 51.5 
               
               
                   
               
               
                  811 
                  723 
                 CGCCGCGUCCGCCUGCAGAUA 
                 1967 
                 UCUGCAGGCGGAGGCGGCGGG 
                 71.1 
                 63.1 
               
               
                   
               
               
                  812 
                  724 
                 GCCGCCUCCGCCUGCAGAUAA 
                 1968 
                 AUCUGCAGGCGGAGGCGGCGG 
                 72.4 
                 64.4 
               
               
                   
               
               
                  813 
                  725 
                 CCGCCUCCGCCUGCAGAUAAC 
                 1969 
                 UAUCUGCAGGCGGAGGCGGCG 
                 77.6 
                 69.6 
               
               
                   
               
               
                  814 
                  726 
                 CGCCUCCGCCUGCAGAUAACC 
                 1970 
                 UUAUCUGCAGGCGGAGGCGGC 
                 77 
                 69 
               
               
                   
               
               
                  815 
                  727 
                 GCCUCCGCCUGCAGAUAACCC 
                 1971 
                 GUUAUCUGCAGGCGGAGGCGG 
                 70.4 
                 62.4 
               
               
                   
               
               
                  816 
                  728 
                 CCUCCGCCUGCAGAUAACCCG 
                 1972 
                 GGUUAUCUGCAGGCGGAGGCG 
                 55.9 
                 47.9 
               
               
                   
               
               
                  817 
                  729 
                 CUCCGCCUGCAGAUAACCCGG 
                 1973 
                 GGGUUAUCUGCAGGCGGAGGC 
                 44.6 
                 36.6 
               
               
                   
               
               
                  818 
                  730 
                 UCCGCCUGCAGAUAACCCGGA 
                 1974 
                 CGGGUUAUCUGCAGGCGGAGG 
                 50.1 
                 42.1 
               
               
                   
               
               
                  819 
                  731 
                 CCGCCUGCAGAUAACCCGGAC 
                 1975 
                 CCGGGUUAUCUGCAGGCGGAG 
                 62.3 
                 54.3 
               
               
                   
               
               
                  820 
                  732 
                 CGCCUGCAGAUAACCCGGACC 
                 1976 
                 UCCGGGUUAUCUGCAGGCGGA 
                 76.9 
                 58.9 
               
               
                   
               
               
                  821 
                  733 
                 GCCUGCAGAUAACCCGGACCC 
                 1977 
                 GUCCGGGUUAUCUGCAGGCGG 
                 70 
                 62 
               
               
                   
               
               
                  822 
                  734 
                 CCUGCAGAUAACCCGGACCCU 
                 1978 
                 GGUCCGGGUUAUCUGCAGGCG 
                 60.4 
                 52.4 
               
               
                   
               
               
                  823 
                  735 
                 CUGCAGAUAACCCGGACCCUG 
                 1979 
                 GGGUCCGGGUUAUCUGCAGGC 
                 50.1 
                 42.1 
               
               
                   
               
               
                  824 
                  736 
                 UGCAGAUAACCCGGACCCUGG 
                 1980 
                 AGGGUCCGGGUUAUCUGCAGG 
                 65.3 
                 57.3 
               
               
                   
               
               
                  825 
                  737 
                 GCAGAUAACCGGGACCCUGGU 
                 1981 
                 CAGGGUCCGGGUUAUCUGCAG 
                 69.3 
                 61.3 
               
               
                   
               
               
                  826 
                  738 
                 CAGAUAACCCGGACCCUGGUG 
                 1982 
                 CCAGGGUCCGGGUUAUCUGCA 
                 60.1 
                 52.1 
               
               
                   
               
               
                  827 
                  739 
                 AGAUAACCGGGACCCUGGUGG 
                 1983 
                 ACCAGGGUCGGGGUUAUCUGC 
                 65.2 
                 57.2 
               
               
                   
               
               
                  846 
                  740 
                 GGCUGCCCGAGCCUUUGUGCA 
                 1984 
                 CACAAAGGCUCGGGCAGCCAC 
                 57.7 
                 49.7 
               
               
                   
               
               
                  847 
                  741 
                 GCUGCCCGAGCCUUUGUGCAG 
                 1985 
                 GCACAAAGGCUCGGGCAGCCA 
                 55.2 
                 47.2 
               
               
                   
               
               
                  848 
                  742 
                 CUGCCCGAGCCUUUGUGCAGG 
                 1986 
                 UGCACAAAGGCUCGGGCAGCC 
                 62.1 
                 54.1 
               
               
                   
               
               
                  849 
                  743 
                 UGCCCGAGCCUUUGUGCAGGG 
                 1987 
                 CUGCACAAAGGCUCGGGCAGC 
                 55.2 
                 47.2 
               
               
                   
               
               
                  850 
                  744 
                 GCCCGAGCCUUUGUGCAGGGC 
                 1988 
                 CCUGCACAAAGGCUCGGGCAG 
                 60.4 
                 52.4 
               
               
                   
               
               
                  851 
                  745 
                 CCCGAGCCUUUGUGCAGGGCC 
                 1989 
                 CCCUGCACAAAGGCUCGGGCA 
                 57.7 
                 49.7 
               
               
                   
               
               
                  852 
                  745 
                 CCGAGCCUUUGUGCAGGGCCU 
                 1990 
                 GCCCUGCACAAAGGCUCGGGC 
                 45.9 
                 37.9 
               
               
                   
               
               
                  853 
                  747 
                 CGAGCCUUUGUGCAGGGCCUG 
                 1991 
                 GGCCCUGCACAAAGGCUCGGG 
                 56.3 
                 48.3 
               
               
                   
               
               
                  854 
                  748 
                 GAGCCUUUGUGCAGGGCCUGG 
                 1992 
                 AGGCCCUGCACAAAGGCUCGG 
                 73.6 
                 65.6 
               
               
                   
               
               
                  855 
                  749 
                 AGCCUUUGUGCAGGGCCUGGA 
                 1993 
                 CAGGCCCUGCACAAAGGCUCG 
                 55 
                 47 
               
               
                   
               
               
                  856 
                  750 
                 GCCUUUGUGCAGGGCCUGGAG 
                 1994 
                 CCAGGCCCUGCACAAAGGCUC 
                 50.3 
                 42.3 
               
               
                   
               
               
                  857 
                  751 
                 CCUUUGUGCAGGGCCUGGAGA 
                 1995 
                 UCCAGGCCCUGCACAAAGGCU 
                 69.2 
                 61.2 
               
               
                   
               
               
                  858 
                  752 
                 CUUUGUGCAGGGCCUGGAGAC 
                 1996 
                 CUCCAGGCCCUGCACAAAGGC 
                 54.5 
                 46.5 
               
               
                   
               
               
                  859 
                  753 
                 UUUGUGCAGGGCCUGGAGACU 
                 1997 
                 UCUCCAGGCCCUGCACAAAGG 
                 60.9 
                 52.9 
               
               
                   
               
               
                  860 
                  754 
                 UUGUGCAGGGCCUGGAGACUG 
                 1998 
                 GUCUCCAGGCCCUGCACAAAG 
                 47.9 
                 39.9 
               
               
                   
               
               
                  861 
                  755 
                 UGUGCAGGGCCUGGAGACUGG 
                 1999 
                 AGUCUCCAGGCCCUGCACAAA 
                 60.6 
                 52.6 
               
               
                   
               
               
                  862 
                  756 
                 GUGCAGGGCCUGGAGACUGGA 
                 2000 
                 CAGUCUCCAGGCCCUGCACAA 
                 59.1 
                 51.1 
               
               
                   
               
               
                  863 
                  757 
                 UGCAGGGCCUGGAGACUGGAA 
                 2001 
                 CCAGUCUCCAGGCCCUGCACA 
                 53.4 
                 53.4 
               
               
                   
               
               
                  864 
                  758 
                 GCAGGGCCUGGAGACUGGAAG 
                 2002 
                 UCCAGUCUCCAGGCCCUGCAC 
                 70.4 
                 62.4 
               
               
                   
               
               
                  865 
                  759 
                 CAGGGCCUGGAGACUGGAAGA 
                 2003 
                 UUCCAGUCUCCAGGCCCUGCA 
                 75.6 
                 67.6 
               
               
                   
               
               
                  866 
                  760 
                 AGGGCCUGGAGACUGGAAGAA 
                 2004 
                 CUUCCAGUCUCCAGGCCCUGC 
                 54.1 
                 46.1 
               
               
                   
               
               
                  867 
                  761 
                 GGGCCUGGAGACUGGAAGAAA 
                 2005 
                 UCUUCCAGUCUCCAGGCCCUG 
                 87.6 
                 79.6 
               
               
                   
               
               
                  868 
                  762 
                 GGCCUGGAGACUGGAAGAAAU 
                 2006 
                 UUCUUCCAGUCUCCAGGCCCU 
                 83.3 
                 75.3 
               
               
                   
               
               
                  869 
                  763 
                 GCCUGGAGACUGGAAGAAAUG 
                 2007 
                 UUUCUUCCAGUCUCCAGGCCC 
                 82.9 
                 74.9 
               
               
                   
               
               
                  870 
                  764 
                 CCUGGAGACUGGAAGAAAUGU 
                 2008 
                 AUUUCUUCCAGUCUCCAGGCC 
                 83.3 
                 75.3 
               
               
                   
               
               
                  871 
                  765 
                 CUGGAGACUGGAAGAAAUGUG 
                 2009 
                 CAUUUCUUCCAGUCUCCAGGC 
                 67.1 
                 59.1 
               
               
                   
               
               
                  872 
                  766 
                 UGGAGACUGGAAGAAAUGUGG 
                 2010 
                 ACAUUUCUUCCAGUCUCCAGG 
                 74.6 
                 66.6 
               
               
                   
               
               
                  873 
                  767 
                 GGAGACUGGAAGAAAUGUGGU 
                 2011 
                 CACAUUUCUUCCAGUCUCCAG 
                 80.5 
                 72.5 
               
               
                   
               
               
                  874 
                  768 
                 GAGACUGGAAGAAAUGUGGUC 
                 2012 
                 CCACAUUUCUUCCAGUCUCCA 
                 71.8 
                 63.8 
               
               
                   
               
               
                  875 
                  769 
                 AGACUGGAAGAAAUGUGGUCA 
                 2013 
                 ACCACAUUUCUUCCAGUCUCC 
                 70 
                 62 
               
               
                   
               
               
                  876 
                  770 
                 GACUGGAAGAAAUGUGGUCAG 
                 2014 
                 GACCACAUUUCUUCCAGUCUC 
                 69.5 
                 61.5 
               
               
                   
               
               
                  877 
                  771 
                 ACUGGAAGAAAUGUGGUCAGC 
                 2015 
                 UGACCACAUUUCUUCCAGUCU 
                 75.8 
                 67.8 
               
               
                   
               
               
                  878 
                  772 
                 CUGGAAGAAAUGUGGUCAGCG 
                 2016 
                 CUGACCACAUUUCUUCCAGUC 
                 68.1 
                 60.1 
               
               
                   
               
               
                  879 
                  773 
                 UGGAAGAAAUGUGGUCAGCGA 
                 2017 
                 GCUGACCACAUUUCUUCCAGU 
                 60.4 
                 52.4 
               
               
                   
               
               
                  880 
                  774 
                 GGAAGAAAUGUGGUCAGCGAA 
                 2018 
                 CGCUGACCACAUUUCUUCCAG 
                 68.6 
                 60.6 
               
               
                   
               
               
                  881 
                  775 
                 GAAGAAAUGUGGUCAGCGAAG 
                 2019 
                 UCGCUGACCACAUUUCUUCCA 
                 93 
                 85 
               
               
                   
               
               
                  882 
                  776 
                 AAGAAAUGUGGUCAGCGAAGC 
                 2020 
                 UUCGCUGACCACAUUUCUUCC 
                 82 
                 74 
               
               
                   
               
               
                  883 
                  777 
                 AGAAAUGUGGUCAGCGAAGCG 
                 2021 
                 CUUCGCUGACCACAUUUCUUC 
                 70.4 
                 62.4 
               
               
                   
               
               
                  884 
                  778 
                 GAAAUGUGGUCAGCGAAGCGC 
                 2022 
                 GCUUCGCUGACCACAUUUCUU 
                 69.5 
                 61.5 
               
               
                   
               
               
                  885 
                  779 
                 AAAUGUGGUCAGCGAAGCGCU 
                 2023 
                 CGCUUCGCUGACCACAUUUCU 
                 63.9 
                 55.9 
               
               
                   
               
               
                  886 
                  780 
                 AAUGUGGUCAGCGAAGCGCUU 
                 2024 
                 GCGCUUCGCUGACCACAUUUC 
                 52 
                 44 
               
               
                   
               
               
                  887 
                  781 
                 AUGUGGUCAGCGAAGCGCUUA 
                 2025 
                 AGCGCUUCGCUGACCACAUUU 
                 73.7 
                 65.7 
               
               
                   
               
               
                  888 
                  782 
                 UGUGGUCAGCGAAGCGCUUAA 
                 2026 
                 AAGCGCUUCGCUGACCACAUU 
                 81.9 
                 73.9 
               
               
                   
               
               
                  889 
                  783 
                 GUGGUCAGCGAAGCGCUUAAG 
                 2027 
                 UAAGCGCUUCGCUGACCACAU 
                 81.6 
                 73.6 
               
               
                   
               
               
                  890 
                  784 
                 UGGUCAGCGAAGCGCUUAAGG 
                 2028 
                 UUAAGCGCUUCGCUGACCACA 
                 85.8 
                 77.8 
               
               
                   
               
               
                  891 
                  785 
                 GGUCAGCGAAGCGCUUAAGGU 
                 2029 
                 CUUAAGCGCUUCGCUGACCAC 
                 70.6 
                 62.6 
               
               
                   
               
               
                  892 
                  786 
                 GUCAGCGAAGCGCUUAAGGUG 
                 2030 
                 CCUUAAGCGCUUCGCUGACCA 
                 58.6 
                 50.6 
               
               
                   
               
               
                  893 
                  787 
                 UCAGCGAAGCGCUUAAGGUGC 
                 2031 
                 ACCUUAAGCGCUUCGCUGACC 
                 60 
                 52 
               
               
                   
               
               
                  894 
                  788 
                 CAGCGAAGCGCUUAAGGUGCC 
                 2032 
                 CACCUUAAGCGCUUCGCUGAC 
                 67.2 
                 59.2 
               
               
                   
               
               
                  895 
                  789 
                 AGCGAAGCGCUUAAGGUGCCG 
                 2033 
                 GCACCUUAAGCGCUUCGCUGA 
                 65.1 
                 57.1 
               
               
                   
               
               
                  896 
                  790 
                 GCGAAGCGCUUAAGGUGCCGG 
                 2034 
                 GGCACCUUAAGCGCUUCGCUG 
                 68.3 
                 60.3 
               
               
                   
               
               
                  897 
                  791 
                 CGAAGCGCUUAAGGUGCCGGU 
                 2035 
                 CGGCACCUUAAGCGCUUCGCU 
                 60.4 
                 52.4 
               
               
                   
               
               
                  898 
                  792 
                 GAAGCGCUUAAGGUGCCGGUG 
                 2036 
                 CCGGCACCUUAAGCGCUUCGC 
                 51.1 
                 43.1 
               
               
                   
               
               
                  899 
                  793 
                 AAGCGCUUAAGGUGCCGGUGU 
                 2037 
                 ACCGGCACCUUAAGCGCUUCG 
                 62.4 
                 54.4 
               
               
                   
               
               
                  900 
                  794 
                 AGCGCUUAAGGUGCCGGUGUC 
                 2038 
                 CACCGGCACCUUAAGCGCUUC 
                 56.3 
                 47.3 
               
               
                   
               
               
                  901 
                  795 
                 GCGCUUAAGGUGCCGGUGUCU 
                 2039 
                 ACACCGGCACCUUAAGCGCUU 
                 76.2 
                 67.2 
               
               
                   
               
               
                  902 
                  796 
                 CGCUUAAGGUGCCGGUGUCUG 
                 2040 
                 GACACCGGCACCUUAAGCGCU 
                 70.2 
                 61.2 
               
               
                   
               
               
                  903 
                  797 
                 GCUUAAGGUGCCGGUGUCUGA 
                 2041 
                 AGACACCGGCACCUUAAGCGC 
                 69 
                 60 
               
               
                   
               
               
                  904 
                  798 
                 CUUAAGGUGCCGGUGUCUGAA 
                 2042 
                 CAGACACCGGCACCUUAAGCG 
                 60.1 
                 51.1 
               
               
                   
               
               
                  905 
                  799 
                 UUAAGGUGCCGGUGUCUGAAG 
                 2043 
                 UCAGACACCGGCACCUUAAGC 
                 65.2 
                 56.2 
               
               
                   
               
               
                  906 
                  800 
                 UAAGGUGCCGGUGUCUGAAGG 
                 2044 
                 UUCAGACACCGGCACCUUAAG 
                 73.2 
                 64.2 
               
               
                   
               
               
                  907 
                  801 
                 AAGGUGCCGGUGUCUGAAGGC 
                 2045 
                 CUUCAGACACCGGCACCUUAA 
                 62.8 
                 53.8 
               
               
                   
               
               
                  908 
                  802 
                 AGGUGCCGGUGUCUGAAGGCU 
                 2046 
                 CCUUCAGACACCGGCACCUUA 
                 62.1 
                 53.1 
               
               
                   
               
               
                  909 
                  803 
                 GGUGCCGGUGUCUGAAGGCUG 
                 2047 
                 GCCUUCAGACACCGGCACCUU 
                 60.9 
                 51.9 
               
               
                   
               
               
                  910 
                  804 
                 GUGCCGGUGUCUGAAGGCUGC 
                 2048 
                 AGCCUUCAGACACCGGCACCU 
                 66.8 
                 57.8 
               
               
                   
               
               
                  911 
                  805 
                 UGCCGGUGUCUGAAGGCUGCA 
                 2049 
                 CAGCCUUCAGACACCGGCACC 
                 55.2 
                 46.2 
               
               
                   
               
               
                  912 
                  806 
                 GCCGGUGUCUGAAGGCUGCAG 
                 2050 
                 GCAGCCUUCAGACACCGGCAC 
                 61.4 
                 52.4 
               
               
                   
               
               
                  913 
                  807 
                 CCGGUGUCUGAAGGCUGCAGC 
                 2051 
                 UGCAGCCUUCAGACACCGGCA 
                 76.5 
                 67.5 
               
               
                   
               
               
                  914 
                  808 
                 CGGUGUCUGAAGGCUGCAGCC 
                 2052 
                 CUGCAGCCUUCAGACACCGGC 
                 66.5 
                 57.5 
               
               
                   
               
               
                  915 
                  809 
                 GGUGUCUGAAGGCUGCAGCCA 
                 2053 
                 GCUGCAGCCUUCAGACACCGG 
                 65.3 
                 56.3 
               
               
                   
               
               
                  916 
                  810 
                 GUGUCUGAAGGCUGCAGCCAG 
                 2054 
                 GGCUGCAGCCUUCAGACACCG 
                 58.8 
                 49.8 
               
               
                   
               
               
                  935 
                  811 
                 AGGCUCUGAUGCGUCUCAUCG 
                 2055 
                 AUGAGACGCAUCAGAGCCUGG 
                 77 
                 68 
               
               
                   
               
               
                  936 
                  812 
                 GGCUCUGAUGCGUCUCAUCGG 
                 2056 
                 GAUGAGACGCAUCAGAGCCUG 
                 76.5 
                 67.5 
               
               
                   
               
               
                  937 
                  813 
                 GCUCUGAUGCGUCUCAUCGGC 
                 2057 
                 CGAUGAGACGCAUCAGAGCCU 
                 65 
                 56 
               
               
                   
               
               
                  938 
                  814 
                 CUCUGAUGCGUCUCAUCGGCU 
                 2058 
                 CCGAUGAGACGCAUCAGAGCC 
                 55.3 
                 46.3 
               
               
                   
               
               
                  939 
                  815 
                 UCUGAUGCGUCUCAUCGGCUG 
                 2059 
                 GCCGAUGAGACGCAUCAGAGC 
                 46.4 
                 37.4 
               
               
                   
               
               
                  940 
                  816 
                 CUGAUGCGUCUCAUCGGCUGU 
                 2060 
                 AGCCGAUGAGACGCAUCAGAG 
                 64.6 
                 55.6 
               
               
                   
               
               
                  941 
                  817 
                 UGAUGCGUCUCAUCGGCUGUC 
                 2061 
                 CAGCCGAUGAGACGCAUCAGA 
                 62.1 
                 53.1 
               
               
                   
               
               
                  942 
                  818 
                 GAUGCGUCUCAUCGGCUGUCC 
                 2062 
                 ACAGCCGAUGAGACGCAUCAG 
                 79.4 
                 70.4 
               
               
                   
               
               
                  943 
                  819 
                 AUGCGUCUCAUCGGCUGUCCC 
                 2063 
                 GACAGCCGAUGAGACGCAUCA 
                 50.9 
                 41.9 
               
               
                   
               
               
                  979 
                  820 
                 CCCUCACUUAUGCCCUGCCAG 
                 2064 
                 GGCAGGGCAUAAGUGAGGGGA 
                 54.5 
                 45.5 
               
               
                   
               
               
                  998 
                  821 
                 AGGGCUUCUGCCUCAACGUGG 
                 2065 
                 ACGUUGAGGCAGAAGCCCUGG 
                 71 
                 62 
               
               
                   
               
               
                  999 
                  822 
                 GGGCUUCUGCCUCAACGUGGU 
                 2066 
                 CACGUUGAGGCAGAAGCCCUG 
                 71 
                 62 
               
               
                   
               
               
                 1000 
                  823 
                 GGCUUCUGCCUCAACGUGGUU 
                 2067 
                 CCACGUUGAGGCAGAAGCCCU 
                 62 
                 52 
               
               
                   
               
               
                 1001 
                  824 
                 GCUUCUGCCUCAACGUGGUUC 
                 2068 
                 ACCACGUUGAGGCAGAAGCCC 
                 71.6 
                 61.6 
               
               
                   
               
               
                 1002 
                  825 
                 CUUCUGCCUCAACGUGGUUCG 
                 2069 
                 AACCACGUUGAGGCAGAAGCC 
                 66.5 
                 56.5 
               
               
                   
               
               
                 1003 
                  826 
                 UUCUGCCUCAACGUGGUUCGU 
                 2070 
                 GAACCACGUUGAGGCAGAAGC 
                 38.9 
                 28.9 
               
               
                   
               
               
                 1004 
                  827 
                 UCUGCCUCAACGUGGUUCGUG 
                 2071 
                 CGAACCACGUUGAGGCAGAAG 
                 54.1 
                 44.1 
               
               
                   
               
               
                 1005 
                  828 
                 CUGCCUCAACGUGGUUCGUGG 
                 2072 
                 ACGAACCACGUUGAGGCAGAA 
                 68.2 
                 58.2 
               
               
                   
               
               
                 1059 
                  829 
                 GGGCAACUAUCUGGAUGGUCU 
                 2073 
                 ACCAUCCAGAUAGUUGCCCCA 
                 75 
                 65 
               
               
                   
               
               
                 1060 
                  830 
                 GGCAACUAUCUGGAUGGUCUC 
                 2074 
                 GACCAUCCAGAUAGUUGCCCC 
                 58 
                 48 
               
               
                   
               
               
                 1061 
                  831 
                 GCAACUAUCUGGAUGGUCUCC 
                 2075 
                 AGACCAUCCAGAUAGUUGCCC 
                 74.9 
                 64.9 
               
               
                   
               
               
                 1062 
                  832 
                 CAACUAUCUGGAUGGUCUCCU 
                 2076 
                 GAGACCAUCCAGAUAGUUGCC 
                 65.7 
                 55.7 
               
               
                   
               
               
                 1063 
                  833 
                 AACUAUCUGGAUGGUCUCCUG 
                 2077 
                 GGAGACCAUCCAGAUAGUUGC 
                 48.8 
                 38.8 
               
               
                   
               
               
                 1064 
                  834 
                 ACUAUCUGGAUGGUCUCCUGA 
                 2078 
                 AGGAGACCAUCCAGAUAGUUG 
                 64.4 
                 54.4 
               
               
                   
               
               
                 1065 
                  835 
                 CUAUCUGGAUGGUCUCCUGAU 
                 2079 
                 CAGGAGACCAUCCAGAUAGUU 
                 74.1 
                 64.1 
               
               
                   
               
               
                 1066 
                  836 
                 UAUCUGGAUGGUCUCCUGAUC 
                 2080 
                 UCAGGAGACCAUCCAGAUAGU 
                 70.1 
                 60.1 
               
               
                   
               
               
                 1067 
                  837 
                 AUCUGGAUGGUCUCCUGAUCC 
                 2081 
                 AUCAGGAGACCAUCCAGAUAG 
                 73.9 
                 63.9 
               
               
                   
               
               
                 1068 
                  838 
                 UCUGGAUGGUCUCCUGAUCCU 
                 2082 
                 GAUCAGGAGACCAUCCAGAUA 
                 64.5 
                 54.5 
               
               
                   
               
               
                 1069 
                  839 
                 CUGGAUGGUCUCCUGAUCCUG 
                 2083 
                 GGAUCAGGAGACCAUCCAGAU 
                 57 
                 47 
               
               
                   
               
               
                 1070 
                  840 
                 UGGAUGGUCUCCUGAUCCUGG 
                 2084 
                 AGGAUCAGGAGACCAUCCAGA 
                 71.6 
                 61.6 
               
               
                   
               
               
                 1089 
                  841 
                 GGCUGAUAAGCUCCAGGGCCC 
                 2085 
                 GCCCUGGAGCUUAUCAGCCAG 
                 63.4 
                 53.4 
               
               
                   
               
               
                 1112 
                  842 
                 UUUCCUUUGAGCUGACGGCCG 
                 2086 
                 GCCGUCAGCUCAAAGGAAAAG 
                 45.3 
                 34.3 
               
               
                   
               
               
                 1113 
                  843 
                 UUCCUUUGAGCUGACGGCCGA 
                 2087 
                 GGCCGUCAGCUCAAAGGAAAA 
                 36.6 
                 25.6 
               
               
                   
               
               
                 1114 
                  844 
                 UCCUUUGAGCUGACGGCCGAG 
                 2088 
                 CGGCCGUCAGCUCAAAGGAAA 
                 47.2 
                 36.2 
               
               
                   
               
               
                 1115 
                  845 
                 CCUUUGAGCUGACGGCCGAGU 
                 2089 
                 UCGGCCGUCAGCUCAAAGGAA 
                 81.2 
                 70.2 
               
               
                   
               
               
                 1116 
                  846 
                 CUUUGAGCUGACGGCCGAGUC 
                 2090 
                 CUCGGCCGUCAGCUCAAAGGA 
                 59.7 
                 48.7 
               
               
                   
               
               
                 1117 
                  847 
                 UUUGAGCUGACGGCCGAGUCC 
                 2091 
                 ACUCGGCCGUCAGCUCAAAGG 
                 54.1 
                 43.1 
               
               
                   
               
               
                 1118 
                  848 
                 UUGAGCUGACGGCCGAGUCCA 
                 2092 
                 GACUCGGCCGUCAGCUCAAAG 
                 50.2 
                 39.2 
               
               
                   
               
               
                 1119 
                  849 
                 UGAGCUGACGGCCGAGUCCAU 
                 2093 
                 GGACUCGGCCGUCAGCUCAAA 
                 54 
                 43 
               
               
                   
               
               
                 1120 
                  850 
                 GAGCUGACGGCCGAGUCCAUU 
                 2094 
                 UGGACUCGGCCGUCAGCUCAA 
                 77.8 
                 66.8 
               
               
                   
               
               
                 1121 
                  851 
                 AGCUGACGGCCGAGUCCAUUG 
                 2095 
                 AUGGACUCGGCCGUCAGCUCA 
                 77.7 
                 66.7 
               
               
                   
               
               
                 1122 
                  852 
                 GCUGACGGCCGAGUCCAUUGG 
                 2096 
                 AAUGGACUCGGCCGUCAGCUC 
                 68.2 
                 57.2 
               
               
                   
               
               
                 1123 
                  853 
                 CUGACGGCCGAGUCCAUUGGG 
                 2097 
                 CAAUGGACUCGGCCGUCAGCU 
                 62.8 
                 51.8 
               
               
                   
               
               
                 1142 
                  854 
                 GGGUGAAGAUCUCGGAGGGUU 
                 2098 
                 CCCUCCGAGAUCUUCACCCCA 
                 65.6 
                 54.6 
               
               
                   
               
               
                 1143 
                  855 
                 GGUGAAGAUCUCGGAGGGUUU 
                 2099 
                 ACCCUCCGAGAUCUUCACCCC 
                 64.3 
                 53.3 
               
               
                   
               
               
                 1144 
                  856 
                 GUGAAGAUCUCGGAGGGUUUG 
                 2100 
                 AACCCUCCGAGAUCUUCACCC 
                 67.2 
                 56.2 
               
               
                   
               
               
                 1145 
                  857 
                 UGAAGAUCUCGGAGGGUUUGA 
                 2101 
                 AAACCCUCCGAGAUCUUCACC 
                 67.7 
                 56.7 
               
               
                   
               
               
                 1146 
                  858 
                 GAAGAUCUCGGAGGGUUUGAU 
                 2102 
                 CAAACCCUCCGAGAUCUUCAC 
                 62.6 
                 51.6 
               
               
                   
               
               
                 1147 
                  859 
                 AAGAUCUCGGAGGGUUUGAUG 
                 2103 
                 UCAAACCCUCCGAGAUCUUCA 
                 67.3 
                 56.3 
               
               
                   
               
               
                 1148 
                  860 
                 AGAUCUCGGAGGGUUUGAUGU 
                 2104 
                 AUCAAACCCUCCGAGAUCUUC 
                 69.5 
                 58.5 
               
               
                   
               
               
                 1149 
                  861 
                 GAUCUCGGAGGGUUUGAUGUA 
                 2105 
                 CAUCAAACCCUCCGAGAUCUU 
                 65.6 
                 54.6 
               
               
                   
               
               
                 1150 
                  862 
                 AUCUCGGAGGGUUUGAUGUAC 
                 2106 
                 ACAUCAAACCCUCCGAGAUCU 
                 62.6 
                 51.6 
               
               
                   
               
               
                 1151 
                  863 
                 UCUCGGAGGGUUUGAUGUACC 
                 2107 
                 UACAUCAAACCCUCCGAGAUC 
                 73.3 
                 62.3 
               
               
                   
               
               
                 1152 
                  864 
                 CUCGGAGGGUUUGAUGUACCU 
                 2108 
                 GUACAUCAAACCCUCCGAGAU 
                 65 
                 54 
               
               
                   
               
               
                 1153 
                  865 
                 UCGGAGGGUUUGAUGUACCUG 
                 2109 
                 GGUACAUCAAACCCUCCGAGA 
                 54.9 
                 43.9 
               
               
                   
               
               
                 1154 
                  866 
                 CGGAGGGUUUGAUGUACCUGC 
                 2110 
                 AGGUACAUCAAACCCUCCGAG 
                 84 
                 73 
               
               
                   
               
               
                 1155 
                  867 
                 GGAGGGUUUGAUGUACCUGCA 
                 2111 
                 CAGGUACAUCAAACCCUCCGA 
                 72.8 
                 61.8 
               
               
                   
               
               
                 1156 
                  865 
                 GAGGGUUUGAUGUACCUGCAG 
                 2112 
                 GCAGGUACAUCAAACCCUCCG 
                 67 
                 56 
               
               
                   
               
               
                 1157 
                  869 
                 AGGGUUUGAUGUACCUGCAGG 
                 2113 
                 UGCAGGUACAUCAAACCCUCC 
                 77.7 
                 66 
               
               
                   
               
               
                 1158 
                  870 
                 GGGUUUGAUGUACCUGCAGGA 
                 2114 
                 CUGCAGGUACAUCAAACCCUC 
                 72.3 
                 61.3 
               
               
                   
               
               
                 1159 
                  871 
                 GGUUUGAUGUACCUGCAGGAA 
                 2115 
                 CCUGCAGGUACAUCAAACCCU 
                 72.4 
                 61.4 
               
               
                   
               
               
                 1160 
                  872 
                 GUUUGAUGUACCUGCAGGAAA 
                 2116 
                 UCCUGCAGGUACAUCAAACCC 
                 76.7 
                 65.7 
               
               
                   
               
               
                 1179 
                  873 
                 AAACAGUGCGAAGGUGUCCGC 
                 2117 
                 GGACACCUUCGCACUGUUUUC 
                 54.4 
                 43.4 
               
               
                   
               
               
                 1180 
                  874 
                 AACAGUGCGAAGGUGUCCGCC 
                 2118 
                 CGGACACCUUCGCACUGUUUU 
                 59 
                 48 
               
               
                   
               
               
                 1181 
                  875 
                 ACAGUGCGAAGGUGUCCGCCC 
                 2119 
                 GCGGACACCUUCGCACUGUUU 
                 62.6 
                 51.6 
               
               
                   
               
               
                 1182 
                  876 
                 CAGUGCGAAGGUGUCCGCCCA 
                 2120 
                 GGCGGACACCUUCGCACUGUU 
                 54.8 
                 43.8 
               
               
                   
               
               
                 1183 
                  877 
                 AGUGCGAAGGUGUCCGCCCAG 
                 2121 
                 GGGCGGACACCUUCGCACUGU 
                 60.1 
                 49.1 
               
               
                   
               
               
                 1184 
                  878 
                 GUGCGAAGGUGUCCGCCCAGG 
                 2122 
                 UGGGCGGACACCUUCGCACUG 
                 84.3 
                 73.3 
               
               
                   
               
               
                 1185 
                  879 
                 UGCGAAGGUGUCCGCCCAGGU 
                 2123 
                 CUGGGCGGACACCUUCGCACU 
                 57.9 
                 46.9 
               
               
                   
               
               
                 1186 
                  880 
                 GCGAAGGUGUCCGCCCAGGUG 
                 2124 
                 CCUGGGCGGACACCUUCGCAC 
                 55.7 
                 44.7 
               
               
                   
               
               
                 1187 
                  881 
                 CGAAGGUGUCCGCCCAGGUGU 
                 2125 
                 ACCUGGGCGGACACCUUCGCA 
                 73.5 
                 62.5 
               
               
                   
               
               
                 1188 
                  882 
                 GAAGGUGUCCGCCCAGGUGUU 
                 2126 
                 CACCUGGGCGGACACCUUCGC 
                 61.5 
                 50.5 
               
               
                   
               
               
                 1189 
                  883 
                 AAGGUGUCCGCCCAGGUGUUU 
                 2127 
                 ACACCUGGGCGGACACCUUCG 
                 66.1 
                 55.1 
               
               
                   
               
               
                 1190 
                  884 
                 AGGUGUCCGCCCAGGUGUUUC 
                 2128 
                 AACACCUGGGCGGACACCUUC 
                 74.3 
                 63.3 
               
               
                   
               
               
                 1191 
                  885 
                 GGUGUCCGCCCAGGUGUUUCA 
                 2129 
                 AAACACCUGGGCGGACACCUU 
                 77.3 
                 66.3 
               
               
                   
               
               
                 1192 
                  886 
                 GUGUCCGCCCAGGUGUUUCAG 
                 2130 
                 GAAACACCUGGGCGGACACCU 
                 56.6 
                 45.6 
               
               
                   
               
               
                 1193 
                  887 
                 UGUCCGCCCAGGUGUUUCAGG 
                 2131 
                 UGAAACACCUGGGCGGACACC 
                 67.9 
                 56.9 
               
               
                   
               
               
                 1194 
                  888 
                 GUCCGCCCAGGUGUUUCAGGA 
                 2132 
                 CUGAAACACCUGGGCGGACAC 
                 52.1 
                 41.1 
               
               
                   
               
               
                 1195 
                  889 
                 UCCGCCCAGGUGUUUCAGGAG 
                 2133 
                 CCUGAAACACCUGGGCGGACA 
                 43.3 
                 32.3 
               
               
                   
               
               
                 1196 
                  890 
                 CCGCCCAGGUGUUUCAGGAGU 
                 2134 
                 UCCUGAAACACCUGGGCGGAC 
                 70.4 
                 59.4 
               
               
                   
               
               
                 1197 
                  891 
                 CGCCCAGGUGUUUCAGGAGUG 
                 2135 
                 CUCCUGAAACACCUGGGCGGA 
                 69.7 
                 58.7 
               
               
                   
               
               
                 1198 
                  892 
                 GCCCAGGUGUUUCAGGAGUGC 
                 2136 
                 ACUCCUGAAACACCUGGGCGG 
                 80.8 
                 69.8 
               
               
                   
               
               
                 1199 
                  893 
                 CCGAGGUGUUUCAGGAGUGCG 
                 2137 
                 CACUCCUGAAACACCUGGGCG 
                 72.9 
                 61.9 
               
               
                   
               
               
                 1200 
                  894 
                 CCAGGUGUUUCAGGAGUGCGG 
                 2138 
                 GCACUCCUGAAACACCUGGGC 
                 62.5 
                 50.5 
               
               
                   
               
               
                 1201 
                  895 
                 CAGGUGUUUCAGGAGUGCGGC 
                 2139 
                 CGCACUCCUGAAACACCUGGG 
                 69 
                 57 
               
               
                   
               
               
                 1202 
                  896 
                 AGGUGUUUCAGGAGUGCGGCC 
                 2140 
                 CCGCACUCCUGAAACACCUGG 
                 71.9 
                 59.9 
               
               
                   
               
               
                 1203 
                  897 
                 GGUGUUUCAGGAGUGCGGCCC 
                 2141 
                 GCCGCACUCCUGAAACACCUG 
                 66.1 
                 54.1 
               
               
                   
               
               
                 1225 
                  898 
                 CCCGACCCGGUGCCUGCCCGC 
                 2142 
                 GGGCAGGCACCGGGUCGGGGG 
                 49 
                 37 
               
               
                   
               
               
                 1226 
                  899 
                 CCGACCCGGUGCCUGCCCGCA 
                 2143 
                 CGGGCAGGCACCGGGUCGGGG 
                 55.5 
                 43.5 
               
               
                   
               
               
                 1227 
                  900 
                 CGACCCGGUGCCUGCCCGCAA 
                 2144 
                 GCGGGCAGGCACCGGGUCGGG 
                 56 
                 44 
               
               
                   
               
               
                 1228 
                  901 
                 GACCCGGUGCCUGCCCGCAAC 
                 2145 
                 UGCGGGCAGGCACCGGGUCGG 
                 69.1 
                 57.1 
               
               
                   
               
               
                 1229 
                  902 
                 ACCCGGUGCCUGCCCGCAACC 
                 2146 
                 UUGCGGGCAGGCACCGGGUCG 
                 74.1 
                 62.1 
               
               
                   
               
               
                 1230 
                  903 
                 CCCGGUGCCUGCCCGCAACCG 
                 2147 
                 GUUGCGGGCAGGCACCGGGUC 
                 57.1 
                 45.1 
               
               
                   
               
               
                 1231 
                  904 
                 CCGGUGCCUGCCCGCAACCGU 
                 2148 
                 GGUUGCGGGCAGGCACCGGGU 
                 52.7 
                 40.7 
               
               
                   
               
               
                 1232 
                  905 
                 CGGUGCCUGCCCGCAACCGUC 
                 2149 
                 CGGUUGCGGGCAGGCACCGGG 
                 55.2 
                 43.2 
               
               
                   
               
               
                 1233 
                  906 
                 GGUGCCUGCCCGCAACCGUCG 
                 2150 
                 ACGGUUGCGGGCAGGCACCGG 
                 71.6 
                 59.6 
               
               
                   
               
               
                 1234 
                  907 
                 GUGCCUGCCCGCAACCGUCGA 
                 2151 
                 GACGGUUGCGGGCAGGCACCG 
                 57.2 
                 45.2 
               
               
                   
               
               
                 1235 
                  908 
                 UGCCUGCCCGCAACCGUCGAG 
                 2152 
                 CGACGGUUGCGGGCAGGCACC 
                 38.1 
                 26.1 
               
               
                   
               
               
                 1236 
                  909 
                 GCCUGCCCGCAACCGUCGAGC 
                 2153 
                 UCGACGGUUGCGGGCAGGCAC 
                 68.9 
                 56.9 
               
               
                   
               
               
                 1237 
                  910 
                 CCUGCCCGCAACCGUCGAGCC 
                 2154 
                 CUCGACGGUUGCGGGCAGGCA 
                 56.1 
                 44.1 
               
               
                   
               
               
                 1238 
                  911 
                 CUGCCCGCAACCGUCGAGCCC 
                 2155 
                 GCUCGACGGUUGCGGGCAGGC 
                 37.4 
                 25.4 
               
               
                   
               
               
                 1265 
                  912 
                 CCCGGGAAGAGGCGGGCCGGC 
                 2156 
                 CGGCCCGCCUCUUCCCGGGGC 
                 44.2 
                 32.2 
               
               
                   
               
               
                 1266 
                  913 
                 CCGGGAAGAGGCGGGCCGGCU 
                 2157 
                 CCGGCCCGCCUCUUCCCGGGG 
                 51.1 
                 39.1 
               
               
                   
               
               
                 1267 
                  914 
                 CGGGAAGAGGCGGGCCGGCUG 
                 2158 
                 GCCGGCCCGCCUCUUCCCGGG 
                 47.8 
                 35.8 
               
               
                   
               
               
                 1268 
                  915 
                 GGGAAGAGGCGGGCCGGCUGU 
                 2159 
                 AGCCGGCCCGCCUCUUCCCGG 
                 62.6 
                 50.6 
               
               
                   
               
               
                 1269 
                  916 
                 GGAAGAGGCGGGCCGGCUGUG 
                 2160 
                 CAGCCGGCCCGCCUCUUCCCG 
                 63.4 
                 51.4 
               
               
                   
               
               
                 1270 
                  917 
                 GAAGAGGCGGGCCGGCUGUGG 
                 2161 
                 ACAGCCGGCCCGCCUCUUCCC 
                 59.1 
                 47.1 
               
               
                   
               
               
                 1271 
                  918 
                 AAGAGGCGGGCCGGCUGUGGU 
                 2162 
                 CACAGCCGGCCCGCCUCUUCC 
                 42.4 
                 30.4 
               
               
                   
               
               
                 1272 
                  919 
                 AGAGGCGGGCCGGCUGUGGUC 
                 2163 
                 CCACAGCCGGCCCGCCUCUUC 
                 42.9 
                 30.9 
               
               
                   
               
               
                 1273 
                  920 
                 GAGGCGGGCCGGCUGUGGUCG 
                 2164 
                 ACCACAGCCGGCCCGCCUCUU 
                 65.8 
                 53.8 
               
               
                   
               
               
                 1274 
                  921 
                 AGGCGGGCCGGCUGUGGUCGA 
                 2165 
                 GACCACAGCCGGCCCGCCUCU 
                 53.8 
                 41.8 
               
               
                   
               
               
                 1275 
                  922 
                 GGCGGGCCGGCUGUGGUCGAU 
                 2166 
                 CGACCACAGCCGGCCCGCCUC 
                 48.2 
                 36.2 
               
               
                   
               
               
                 1276 
                  923 
                 GCGGGCCGGCUGUGGUCGAUG 
                 2167 
                 UCGACCACAGCCGGCCCGCCU 
                 74.9 
                 62.9 
               
               
                   
               
               
                 1277 
                  924 
                 CGGGCCGGCUGUGGUCGAUGG 
                 2168 
                 AUCGACCACAGCCGGCCCGCC 
                 65.7 
                 53.7 
               
               
                   
               
               
                 1278 
                  925 
                 GGGCCGGCUGUGGUCGAUGGU 
                 2169 
                 CAUCGACCACAGCCGGCCCGC 
                 59 
                 47 
               
               
                   
               
               
                 1279 
                  926 
                 GGCCGGCUGUGGUCGAUGGUG 
                 2170 
                 CCAUCGACCACAGCCGGCCCG 
                 71.2 
                 59.2 
               
               
                   
               
               
                 1280 
                  927 
                 GCCGGCUGUGGUCGAUGGUGA 
                 2171 
                 ACCAUCGACCACAGCCGGCCC 
                 67.3 
                 55.3 
               
               
                   
               
               
                 1281 
                  928 
                 CCGGCUGUGGUCGAUGGUGAC 
                 2172 
                 CACCAUCGACCACAGCCGGCC 
                 59.6 
                 47.6 
               
               
                   
               
               
                 1282 
                  929 
                 CGCCUGUGGUCGAUGGUGACC 
                 2173 
                 UCACCAUCGACCACAGCCGGC 
                 85.3 
                 73.3 
               
               
                   
               
               
                 1283 
                  930 
                 GGCUGUGGUCGAUGGUGACCG 
                 2174 
                 GUCACCAUCGACCACAGCCGG 
                 82.9 
                 70.9 
               
               
                   
               
               
                 1284 
                  931 
                 GCUGUGGUCCAUGGUGACCGA 
                 2175 
                 GGUCACCAUCGACCACAGCCG 
                 64.5 
                 52.5 
               
               
                   
               
               
                 1285 
                  932 
                 CUGUGGUaGAUGGUGACCGAG 
                 2176 
                 CGGUCACCAUCGACCACAGCC 
                 52.2 
                 40.2 
               
               
                   
               
               
                 1286 
                  933 
                 UGUGGUCGAUGGUGACCGAGG 
                 2177 
                 UCGGUCACCAUCGACCACAGC 
                 81.5 
                 69.5 
               
               
                   
               
               
                 1287 
                  934 
                 GUGGUCGAUGGUGACCGAGGA 
                 2178 
                 CUCGGUCACCAUCGACCACAG 
                 65.9 
                 53.9 
               
               
                   
               
               
                 1288 
                  935 
                 UGGUCGAUGGUGACCGAGGAG 
                 2179 
                 CCUCGGUCACCAUCGACCACA 
                 60.2 
                 48.2 
               
               
                   
               
               
                 1289 
                  936 
                 GGUCGAUGGUGACCGAGGAGG 
                 2180 
                 UCCUCGGUCACCAUCGACCAC 
                 88.9 
                 76.9 
               
               
                   
               
               
                 1290 
                  937 
                 GUCGAUGGUGACCGAGGAGGA 
                 2181 
                 CUCCUCGGUCACCAUCGACCA 
                 68.1 
                 56.1 
               
               
                   
               
               
                 1291 
                  938 
                 UCGAUGGUGACCGAGGAGGAG 
                 2182 
                 CCUCCUCGGUCACCAUCGACC 
                 44 
                 32 
               
               
                   
               
               
                 1292 
                  939 
                 CGAUGGUGACCGAGGAGGAGC 
                 2183 
                 UCCUCCUCGGUCACCAUCGAC 
                 84.9 
                 72.9 
               
               
                   
               
               
                 1293 
                  940 
                 GAUGGUGACCGAGGAGGAGCG 
                 2184 
                 CUCCUCCUCGGUCACCAUCGA 
                 70.6 
                 58.6 
               
               
                   
               
               
                 1294 
                  941 
                 AUGGUGACCGAGGAGGAGCGG 
                 2185 
                 GCUCCUCCUCGGUCACCAUCG 
                 49.1 
                 37.1 
               
               
                   
               
               
                 1295 
                  942 
                 UGGUGACCGAGGAGGAGCGGC 
                 2186 
                 CGCUCCUCCUCGGUCACCAUC 
                 52.5 
                 40.5 
               
               
                   
               
               
                 1296 
                  943 
                 GGUGACCGAGGAGGAGCGGCC 
                 2187 
                 CCGCUCCUCCUCGGUCACCAU 
                 61.4 
                 49.4 
               
               
                   
               
               
                 1297 
                  944 
                 GUGACCGAGGAGGAGCGGCCC 
                 2188 
                 GCCGCUCCUCCUCGGUCACCA 
                 47.4 
                 35.4 
               
               
                   
               
               
                 1298 
                  945 
                 UGACCGAGGAGGAGCGGCCCA 
                 2189 
                 GGCCGCUCCUCCUCGGUCACC 
                 41 
                 29 
               
               
                   
               
               
                 1299 
                  946 
                 GACCGAGGAGGAGCGGCCCAC 
                 2190 
                 GGGCCGCUCCUCCUCGGUCAC 
                 47.4 
                 35.4 
               
               
                   
               
               
                 1300 
                  947 
                 ACCGAGGAGGAGCGGCCCACG 
                 2191 
                 UGGGCCGCUCCUCCUCGGUCA 
                 66.6 
                 53.6 
               
               
                   
               
               
                 1301 
                  948 
                 CCGAGGAGGAGCGGCCCACGA 
                 2192 
                 GUGGGCCGCUCCUCCUCGGUC 
                 53 
                 40 
               
               
                   
               
               
                 1302 
                  949 
                 CGAGGAGGAGCGGCCCACGAC 
                 2193 
                 CGUGGGCCGCUCCUCCUCGGU 
                 59.1 
                 46.1 
               
               
                   
               
               
                 1303 
                  950 
                 GAGGAGGAGCGGCCCACGACG 
                 2194 
                 UCGUGGGCCGCUCCUCCUCGG 
                 80.4 
                 67.4 
               
               
                   
               
               
                 1304 
                  951 
                 AGGAGGAGCGGCCCACGACGG 
                 2195 
                 GUCGUGGGCCGCUCCUCCUCG 
                 80.4 
                 47.4 
               
               
                   
               
               
                 1305 
                  952 
                 GGAGGAGCGGCCCACGACGGC 
                 2196 
                 CGUCGUGGGCCGCUCCUCCUC 
                 61.2 
                 48.2 
               
               
                   
               
               
                 1306 
                  953 
                 GAGGAGCGGCCCACGACGGCC 
                 2197 
                 CCGUCGUGGGCCGCUCCUCCU 
                 58.8 
                 45.8 
               
               
                   
               
               
                 1307 
                  954 
                 AGGAGCGGCCCACGACGGCCG 
                 2198 
                 GCCGUCGUGGGCCGCUCCUCC 
                 41.9 
                 28.9 
               
               
                   
               
               
                 1308 
                  955 
                 GGAGCGGCCCACGACGGCCGC 
                 2199 
                 GGCCGUCGUGGGCCGCUCCUC 
                 49.4 
                 36.4 
               
               
                   
               
               
                 1309 
                  956 
                 GAGCGGCCCACGACGGCCGCA 
                 2200 
                 CGGCCGUCGUGGGCCGCUCCU 
                 53.6 
                 40.6 
               
               
                   
               
               
                 1310 
                  957 
                 AGCGGCCCACGACGGCCGCAG 
                 2201 
                 GCGGCCGUCGUGGGCCGCUCC 
                 39.8 
                 26.8 
               
               
                   
               
               
                 1311 
                  958 
                 GCGGCCCACGACGGCCGCAGG 
                 2202 
                 UGCGGCCGUCGUGGGCCGCUC 
                 60 
                 47 
               
               
                   
               
               
                 1312 
                  959 
                 CGGCCCACGACGGCCGCAGGC 
                 2203 
                 CUGCGGCCGUCGUGGGCCGCU 
                 53.4 
                 40.4 
               
               
                   
               
               
                 1313 
                  960 
                 GGCCCACGACGGCCGCAGGCA 
                 2204 
                 CCUGCGGCCGUCGUGGGCCGC 
                 54.9 
                 41.9 
               
               
                   
               
               
                 1314 
                  961 
                 GCCCACGACGGCCGCAGGCAC 
                 2205 
                 GCCUGCGGCCGUCGUGGGCCG 
                 48.1 
                 35.1 
               
               
                   
               
               
                 1315 
                  962 
                 CCCACGACGGCCGCAGGCACC 
                 2206 
                 UGCCUGCGGCCGUCGUGGGCC 
                 58.7 
                 45.7 
               
               
                   
               
               
                 1316 
                  963 
                 CCACGACGGCCGCAGGCACCA 
                 2207 
                 GUGCCUGCGGCCGUCGUGGGC 
                 59.6 
                 46.6 
               
               
                   
               
               
                 1317 
                  964 
                 CACGACGGCCGCAGGCACCAA 
                 2208 
                 GGUGCCUGCGGCCGUCGUGGG 
                 54.3 
                 41.3 
               
               
                   
               
               
                 1318 
                  965 
                 ACGACGGCCGCAGGCACCAAU 
                 2209 
                 UGGUGCCUGCGGCCGUCGUGG 
                 68.6 
                 55.6 
               
               
                   
               
               
                 1319 
                  966 
                 CGACGGCCGCAGGCACCAACC 
                 2210 
                 UUGGUGCCUGCGGCCGUCGUG 
                 85.8 
                 73.8 
               
               
                   
               
               
                 1320 
                  967 
                 GACGGCCGCAGGCACCAACCU 
                 2211 
                 GUUGGUGCCUGCGGCCGUCGU 
                 59.9 
                 46.9 
               
               
                   
               
               
                 1321 
                  968 
                 ACGGCCGCAGGCACCAACCUG 
                 2212 
                 GGUUGGUGCCUGCGGCCGUCG 
                 45.5 
                 32.5 
               
               
                   
               
               
                 1322 
                  969 
                 CGGCCGCAGGCACCAACCUGC 
                 2213 
                 AGGUUGGUGCCUGCGGCCGUC 
                 64.6 
                 51.6 
               
               
                   
               
               
                 1323 
                  970 
                 GGCCGCAGGCACCAACCUGCA 
                 2214 
                 CAGGUUGGUGCCUGCGGCCGU 
                 65.5 
                 52.5 
               
               
                   
               
               
                 1324 
                  971 
                 GCCGCAGGCACCAACCUGCAC 
                 2215 
                 GCAGGUUGGUGCCUGCGGCCG 
                 58.7 
                 45.7 
               
               
                   
               
               
                 1325 
                  972 
                 CCGCAGGCACCAACCUGCACC 
                 2216 
                 UGCAGGUUGGUGCCUGCGGCC 
                 70.5 
                 57.5 
               
               
                   
               
               
                 1326 
                  973 
                 CGCAGGCACCAACCUGCACCG 
                 2217 
                 GUGCAGGUUGGUGCCUGCGGC 
                 63.2 
                 50.2 
               
               
                   
               
               
                 1327 
                  974 
                 GCAGGCACCAACCUGCACCGG 
                 2218 
                 GGUGCAGGUUGGUGCCUGCGG 
                 58.4 
                 45.4 
               
               
                   
               
               
                 1328 
                  975 
                 CAGGCACCAACCUGCACCGGC 
                 2219 
                 CGGUGCAGGUUGGUGCCUGCG 
                 60 
                 47 
               
               
                   
               
               
                 1329 
                  976 
                 AGGCACCAACCUGCACCGGCU 
                 2220 
                 CCGGUGCAGGUUGGUGCCUGC 
                 46.5 
                 33.5 
               
               
                   
               
               
                 1330 
                  977 
                 GGCACCAACCUGCACCGGCUG 
                 2221 
                 GCCGGUGCAGGUUGGUGCCUG 
                 59.2 
                 46.2 
               
               
                   
               
               
                 1331 
                  978 
                 GCACCAACCUGCACCGGCUGG 
                 2222 
                 AGCCGGUGCAGGUUGGUGCCU 
                 74.1 
                 61.1 
               
               
                   
               
               
                 1332 
                  979 
                 CACCAACCUGCACCGGCUGGU 
                 2223 
                 CAGCCGGUGCAGGUUGGUGCC 
                 56.7 
                 43.7 
               
               
                   
               
               
                 1333 
                  980 
                 ACCAACCUGCACCGGCUGGUG 
                 2224 
                 CCAGCCGGUGCAGGUUGGUGC 
                 46.3 
                 33.3 
               
               
                   
               
               
                 1334 
                  981 
                 CCAACCUGCACCGGCUGGUGU 
                 2225 
                 ACCAGCCGGUGCAGGUUGGUG 
                 65.5 
                 52.5 
               
               
                   
               
               
                 1335 
                  982 
                 CAACCUGCACCGGCUGGUGUG 
                 2226 
                 CACCAGCCGGUGCAGGUUGGU 
                 63 
                 50 
               
               
                   
               
               
                 1336 
                  983 
                 AACCUGCACCGGCUGGUGUGG 
                 2227 
                 ACACCAGCCGGUGCAGGUUGG 
                 66.8 
                 53.8 
               
               
                   
               
               
                 1337 
                  984 
                 ACCUGCACCGGCUGGUGUGGG 
                 2228 
                 CACACCAGCCGGUGCAGGUUG 
                 64.3 
                 51.3 
               
               
                   
               
               
                 1338 
                  955 
                 CCUGCACCGGCUGGUGUGGGA 
                 2229 
                 CCACACCAGCCGGUGCAGGUU 
                 60.7 
                 47.7 
               
               
                   
               
               
                 1339 
                  986 
                 CUGCACCGGCUGGUGUGGGAG 
                 2230 
                 CCCACACCAGCCGGUGCAGGU 
                 47 
                 34 
               
               
                   
               
               
                 1340 
                  987 
                 UGCACCGGCUGGUGUGGGAGC 
                 2231 
                 UCCCACACCAGCCGGUGCAGG 
                 70.3 
                 57.3 
               
               
                   
               
               
                 1341 
                  988 
                 GCACCGGCUGGUGUGGGAGCU 
                 2232 
                 CUCCCACACCAGCCGGUGCAG 
                 62.5 
                 49.5 
               
               
                   
               
               
                 1342 
                  989 
                 CACCGGCUGGUGUGGGAGCUC 
                 2233 
                 GCUCCCACACCAGCCGGUGCA 
                 54.6 
                 41.6 
               
               
                   
               
               
                 1343 
                  990 
                 ACCGGCUGGUGUGGGAGCUCC 
                 2234 
                 AGCUCCCACACCAGCCGGUGC 
                 55.9 
                 42.9 
               
               
                   
               
               
                 1344 
                  991 
                 CCGGCUGGUGUGGGAGCUCCG 
                 2235 
                 GAGCUCCCACACCAGCCGGUG 
                 63.1 
                 50.1 
               
               
                   
               
               
                 1345 
                  992 
                 CGGCUGGUGUGGGAGCUCCGC 
                 2236 
                 GGAGCUCCCACACCAGCCGGU 
                 62.9 
                 49.9 
               
               
                   
               
               
                 1346 
                  993 
                 GGCUGGUGUGGGAGCUCCGCG 
                 2237 
                 CGGAGCUCCCACACCAGCCGG 
                 72.1 
                 59.1 
               
               
                   
               
               
                 1347 
                  994 
                 GCUGGUGUGGGAGCUCCGCGA 
                 2238 
                 GCGGAGCUCCCACACCAGCCG 
                 58.7 
                 45.7 
               
               
                   
               
               
                 1348 
                  995 
                 CUGGUGUGGGAGCUCCGCGAG 
                 2239 
                 CGCGGAGCUCCCACACCAGCC 
                 45.9 
                 32.9 
               
               
                   
               
               
                 1349 
                  996 
                 UGGUGUGGGAGCUCCGCGAGC 
                 2240 
                 UCGCGGAGCUCCCACACCAGC 
                 69.7 
                 56.7 
               
               
                   
               
               
                 1350 
                  997 
                 GGUGUGGGAGCUCCGCGAGCG 
                 2241 
                 CUCGCGGAGCUCCCACACCAG 
                 72 
                 59 
               
               
                   
               
               
                 1351 
                  998 
                 GUGUGGGAGCUCCGCGAGCGU 
                 2242 
                 GCUCGCGGAGCUCCCACACCA 
                 57.8 
                 44.8 
               
               
                   
               
               
                 1352 
                  999 
                 UGUGGGAGCUCCGCGAGCGUC 
                 2243 
                 CGCUCGCGGAGCUCCCACACC 
                 45.4 
                 32.4 
               
               
                   
               
               
                 1353 
                 1000 
                 GUGGGAGCUCCGCGAGCGUCU 
                 2244 
                 ACGCUCGCGGAGCUCCCACAC 
                 63.8 
                 50.8 
               
               
                   
               
               
                 1354 
                 1001 
                 UGGGAGCUCCGCGAGCGUCUG 
                 2245 
                 GACGCUCGCGGAGCUCCCACA 
                 50.5 
                 37.5 
               
               
                   
               
               
                 1355 
                 1002 
                 GGGAGCUCCGCGAGCGUCUGG 
                 2246 
                 AGACGCUCGCGGAGCUCCCAC 
                 67.3 
                 54.3 
               
               
                   
               
               
                 1386 
                 1003 
                 GGGCUUCUGGGCCCGGCUGUC 
                 2247 
                 CAGCCGGGCCCAGAAGCCCCG 
                 57 
                 44 
               
               
                   
               
               
                 1387 
                 1004 
                 GGCUUCUGGGCCCGGCUGUCC 
                 2248 
                 ACAGCCGGGCCCAGAAGCCCC 
                 56.8 
                 43.8 
               
               
                   
               
               
                 1388 
                 1005 
                 GCUUCUGGGCCCGGCUGUCCC 
                 2249 
                 GACAGCCGGGCCCAGAAGCCC 
                 50.8 
                 37.6 
               
               
                   
               
               
                 1389 
                 1006 
                 CUUCUGGGCCCGGCUGUCCCU 
                 2250 
                 GGACAGCCGGGCCCAGAAGCC 
                 36.1 
                 23.1 
               
               
                   
               
               
                 1390 
                 1007 
                 UUCUGGGCCCGGCUGUCCCUG 
                 2251 
                 GGGACAGCCGGGCCCAGAAGC 
                 31.3 
                 18.3 
               
               
                   
               
               
                 1391 
                 1008 
                 UCUGGGCCCGGCUGUCCCUGA 
                 2252 
                 AGGGACAGCCGGGCCCAGAAG 
                 54.2 
                 41.2 
               
               
                   
               
               
                 1392 
                 1009 
                 CUGGGCCCGGCUGUCCCUGAC 
                 2253 
                 CAGGGACAGCCGGGCCCAGAA 
                 44 
                 31 
               
               
                   
               
               
                 1393 
                 1010 
                 UGGGCCCGGCUGUCCCUGACG 
                 2254 
                 UCAGGGACAGCCGGGCCCAGA 
                 80.9 
                 47.9 
               
               
                   
               
               
                 1394 
                 1011 
                 GGGCCCGGCUGUCCCUGACGG 
                 2255 
                 GUCAGGGACAGCCGGGCCCAG 
                 63.1 
                 50.1 
               
               
                   
               
               
                 1395 
                 1012 
                 GGCCCGGCUGUCCCUGACGGU 
                 2256 
                 CGUCAGGGACAGCCGGGCCCA 
                 57.4 
                 44.4 
               
               
                   
               
               
                 1396 
                 1013 
                 GCCCGGCUGUCCCUGACGGUG 
                 2257 
                 CCGUCAGGGACAGCCGGGCCC 
                 52.9 
                 39.9 
               
               
                   
               
               
                 1397 
                 1014 
                 CCCGGCUGUCCCUGACGGUGU 
                 2258 
                 ACCGUCAGGGACAGCCGGGCC 
                 59.9 
                 46.9 
               
               
                   
               
               
                 1398 
                 1015 
                 CCGGCUGUCCCUGACGGUGUG 
                 2259 
                 CACCGUCAGGGACAGCCGGGC 
                 58.9 
                 45.9 
               
               
                   
               
               
                 1399 
                 1016 
                 CGGCUGUCCCUGACGGUGUGC 
                 2260 
                 ACACCGUCAGGGACAGCCGGG 
                 80.9 
                 67.9 
               
               
                   
               
               
                 1400 
                 1017 
                 GGCUGUCCCUGACGGUGUGCG 
                 2261 
                 CACACCGUCAGGGACAGCCGG 
                 81.1 
                 67.1 
               
               
                   
               
               
                 1401 
                 1018 
                 GCUGUCCCUGACGGUGUGCGG 
                 2262 
                 GCACACCGUCAGGGACAGCCG 
                 58.4 
                 44.4 
               
               
                   
               
               
                 1402 
                 1019 
                 CUGUCCCUGACGGUGUGCGGA 
                 2263 
                 CGCACACCGUCAGGGACAGCC 
                 44.7 
                 30.7 
               
               
                   
               
               
                 1403 
                 1020 
                 UGUCCCUGACGGUGUGCGGAG 
                 2264 
                 CCGCACACCGUCAGGGACAGC 
                 53.2 
                 39.2 
               
               
                   
               
               
                 1404 
                 1021 
                 GUCCCUGACGGUGUGCGGAGA 
                 2265 
                 UCCGCACACCGUCAGGGACAG 
                 73.6 
                 59.6 
               
               
                   
               
               
                 1405 
                 1022 
                 UCCCUGACGGUGUGCGGAGAC 
                 2266 
                 CUCCGCACACCGUCAGGGACA 
                 54.6 
                 40.6 
               
               
                   
               
               
                 1406 
                 1023 
                 CCCUGACGGUGUGCGGAGACU 
                 2267 
                 UCUCCGCACACCGUCAGGGAC 
                 76.6 
                 62.6 
               
               
                   
               
               
                 1407 
                 1024 
                 CCUGACGGUGUGCGGAGACUC 
                 2268 
                 GUCUCCGCACACCGUCAGGGA 
                 66.8 
                 52.8 
               
               
                   
               
               
                 1408 
                 1025 
                 CUGACGGUGUGCGGAGACUCU 
                 2269 
                 AGUCUCCGCACACCGUCAGGG 
                 76.3 
                 62.3 
               
               
                   
               
               
                 1409 
                 1026 
                 UGACGGUGUGCGGAGACUCUC 
                 2270 
                 GAGUCUCCGCACACCGUCAGG 
                 66.8 
                 52.1 
               
               
                   
               
               
                 1410 
                 1027 
                 GACGGUGUGCGGAGACUCUCG 
                 2271 
                 AGAGUCUCCGCACACCGUCAG 
                 55.1 
                 71.1 
               
               
                   
               
               
                 1411 
                 1028 
                 ACGGUGUGCGGAGACUCUCGC 
                 2272 
                 GAGAGUCUCCGCACACCGUCA 
                 65.2 
                 51.2 
               
               
                   
               
               
                 1412 
                 1029 
                 CGGUGUGCGGAGACUCUCGCA 
                 2273 
                 CGAGAGUCUCCGCACACCGUC 
                 69.5 
                 55.5 
               
               
                   
               
               
                 1413 
                 1030 
                 GGUGUGCGGAGACUCUCGCAU 
                 2274 
                 GCGAGAGUCUCCGCACACCGU 
                 68.6 
                 54.6 
               
               
                   
               
               
                 1414 
                 1031 
                 GUGUGCGGAGACUCUCGCAUG 
                 2275 
                 UGCGAGAGUCUCCGCACACCG 
                 78.1 
                 64.1 
               
               
                   
               
               
                 1415 
                 1032 
                 UGUGCGGAGACUCUCGCAUGG 
                 2276 
                 AUGCGAGAGUCUCCGCACACC 
                 65.2 
                 51.2 
               
               
                   
               
               
                 1434 
                 1033 
                 GGCAGCGGACGCCUCGCUGGA 
                 2277 
                 CAGCGAGGCGUCCGCUGCCAU 
                 62.5 
                 48.5 
               
               
                   
               
               
                 1435 
                 1034 
                 GCAGCGGACGCCUCGCUGGAG 
                 2278 
                 CCAGCGAGGCGUCCGCUGCCA 
                 60.6 
                 46.6 
               
               
                   
               
               
                 1436 
                 1035 
                 CAGCGGACGCCUCGCUGGAGG 
                 2279 
                 UCCAGCGAGGCGUCCGCUGCC 
                 69.5 
                 55.5 
               
               
                   
               
               
                 1437 
                 1036 
                 AGCGGACGCCUCGCUGGAGGC 
                 2280 
                 CUCCAGCGAGGCGUCCGCUGC 
                 52.1 
                 38.1 
               
               
                   
               
               
                 1438 
                 1037 
                 GCGGACGCGUCGCUGGAGGCG 
                 2281 
                 CCUCCAGCGAGGCGUCCGCUG 
                 59.8 
                 45.8 
               
               
                   
               
               
                 1439 
                 1038 
                 CGGACGCCUCGCUGGAGGCGG 
                 2282 
                 GCCUCCAGCGAGGCGUCCGCU 
                 54.2 
                 40.2 
               
               
                   
               
               
                 1440 
                 1039 
                 GGACGCCUCGCUGGAGGCGGC 
                 2283 
                 CGCCUCCAGCGAGGCGUCCGC 
                 46.6 
                 32.6 
               
               
                   
               
               
                 1441 
                 1040 
                 GACGCCUCGCUGGAGGCGGCG 
                 2284 
                 CCGCCUCCAGCGAGGCGUCCG 
                 50 
                 36 
               
               
                   
               
               
                 1442 
                 1041 
                 ACGCCUCGCUGGAGGCGGCGC 
                 2285 
                 GCCGCCUCCAGCGAGGCGUCC 
                 40.9 
                 26.9 
               
               
                   
               
               
                 1443 
                 1042 
                 CGCCUCGCUGGAGGCGGCGCC 
                 2286 
                 CGCCGCCUCCAGCGAGGCGUC 
                 41.2 
                 27.2 
               
               
                   
               
               
                 1444 
                 1043 
                 GCCUCGCUGGAGGCGGCGCCC 
                 2287 
                 GCGCCGCCUCCAGCGAGGCGU 
                 49.9 
                 35.9 
               
               
                   
               
               
                 1445 
                 1044 
                 CCUCGCUGGAGGCGGCGCCCU 
                 2288 
                 GGCGCCGCCUCCAGCGAGGCG 
                 45.7 
                 31.7 
               
               
                   
               
               
                 1446 
                 1045 
                 CUCGCUGGAGGCGGCGCCCUG 
                 2289 
                 GGGCGCCGCCUCCAGCGAGGC 
                 36.1 
                 22.1 
               
               
                   
               
               
                 1447 
                 1046 
                 UCGCUGGAGGCGGCGCCCUGC 
                 2290 
                 AGGGCGCCGCCUCCAGCGAGG 
                 48.8 
                 34.8 
               
               
                   
               
               
                 1448 
                 1047 
                 CGCUGGAGGCGGCGCCCUGCU 
                 2291 
                 CAGGGCGCCGCCUCCAGCGAG 
                 64.2 
                 50.2 
               
               
                   
               
               
                 1449 
                 1048 
                 GCUGGAGGCGGCGCCCUGCUG 
                 2292 
                 GCAGGGCGCCGCCUCCAGCGA 
                 52.8 
                 38.8 
               
               
                   
               
               
                 1450 
                 1049 
                 CUGGAGGCGGGGCCCUGCUGG 
                 2293 
                 AGCAGGGCGCCGCCUCCAGCG 
                 58.7 
                 44.7 
               
               
                   
               
               
                 1451 
                 1050 
                 UGGAGGCGGGGCCCUGCUGGA 
                 2294 
                 CAGCAGGGCGCCGCCUCCAGC 
                 47.6 
                 33.6 
               
               
                   
               
               
                 1452 
                 1051 
                 GGAGGCGGCGCCCUGCUGGAC 
                 2295 
                 CCAGCAGGGCGCCGCCUCCAG 
                 55.2 
                 41.2 
               
               
                   
               
               
                 1453 
                 1052 
                 GAGGCGGCGCCCUGCUGGACC 
                 2296 
                 UCCAGCAGGGCGCCGCCUCCA 
                 71.9 
                 57.9 
               
               
                   
               
               
                 1454 
                 1053 
                 AGGCGGCGCCCUGCUGGACCG 
                 2297 
                 GUCCAGCAGGGCGCCGCCUCC 
                 45.4 
                 31.4 
               
               
                   
               
               
                 1455 
                 1054 
                 GGCGGCGCCCUGCUGGACCGG 
                 2298 
                 GGUCCAGCAGGGCGCCGCCUC 
                 47.1 
                 33.1 
               
               
                   
               
               
                 1456 
                 1055 
                 GCGGCGCCCUGCUGGACCGGA 
                 2299 
                 CGGUCCAGCAGGGCGCCGCCU 
                 60.4 
                 46.4 
               
               
                   
               
               
                 1457 
                 1056 
                 CGGCGCCCUGCUGGACCGGAG 
                 2300 
                 CCGGUCCAGCAGGGCGCCGCC 
                 44.1 
                 30.1 
               
               
                   
               
               
                 1458 
                 1057 
                 GGCGCCCUGCUGGACCGGAGC 
                 2301 
                 UCCGGUCCAGCAGGGCGCCGC 
                 64.9 
                 50.9 
               
               
                   
               
               
                 1459 
                 1058 
                 GCGCCCUGCUGGACCGGAGCC 
                 2302 
                 CUCCGGUCCAGCAGGGCGCCG 
                 65.7 
                 51.7 
               
               
                   
               
               
                 1460 
                 1059 
                 CGCCCUGCUGGACCGGAGCCG 
                 2303 
                 GCUCCGGUCCAGCAGGGCGCC 
                 51.3 
                 37.3 
               
               
                   
               
               
                 1461 
                 1060 
                 GCCCUGCUGGAGCGGAGCCGG 
                 2304 
                 GGCUCCGGUCCAGCAGGGCGC 
                 48.3 
                 34.3 
               
               
                   
               
               
                 1462 
                 1061 
                 CCCUGCUGGACCGGAGCCGGG 
                 2305 
                 CGGCUCCGGUCCAGCAGGGCG 
                 51.1 
                 37.1 
               
               
                   
               
               
                 1463 
                 1062 
                 CCUGCUGGACCGGAGCCGGGC 
                 2306 
                 CCGGCUCCGGUCGAGCAGGGC 
                 53.1 
                 39.1 
               
               
                   
               
               
                 1464 
                 1063 
                 CUGCUGGACCGGAGCCGGGCG 
                 2307 
                 CCCGGCUCCGGUCCAGCAGGG 
                 55 
                 41 
               
               
                   
               
               
                 1465 
                 1064 
                 UGCUGGACCGGAGCCGGGCGG 
                 2308 
                 GCCCGGCUCCGGUCCAGCAGG 
                 44 
                 30 
               
               
                   
               
               
                 1466 
                 1065 
                 GCUGGACCGGAGCCGGGCGGG 
                 2309 
                 CGCCCGGCUCCGGUCCAGCAG 
                 57.1 
                 43.1 
               
               
                   
               
               
                 1518 
                 1066 
                 CCCGGCCGAGCAGGUCAACAA 
                 2310 
                 GUUGACCUGCUCGGCCGGGGA 
                 58.7 
                 43.7 
               
               
                   
               
               
                 1519 
                 1067 
                 CCGGCCGAGCAGGUCAACAAC 
                 2311 
                 UGUUGACCUGCUCGGCCGGGG 
                 75.2 
                 60.2 
               
               
                   
               
               
                 1520 
                 1068 
                 CGGCCGAGCAGGUCAACAACC 
                 2312 
                 UUGUUGACCUGCUCGGCCGGG 
                 95.7 
                 80.7 
               
               
                   
               
               
                 1521 
                 1069 
                 GGCCGAGCAGGUCAACAACCC 
                 2313 
                 GUUGUUGACCUGCUCGGCCGG 
                 78.4 
                 63.4 
               
               
                   
               
               
                 1540 
                 1070 
                 CCCGAGCUCAAGGUGGACGCC 
                 2314 
                 CGUCCACCUUGAGCUCGGGGU 
                 60.5 
                 45.5 
               
               
                   
               
               
                 1541 
                 1071 
                 CCGAGCUCAAGGUGGACGCCU 
                 2315 
                 GCGUCCACCUUGAGCUCGGGG 
                 65.5 
                 50.5 
               
               
                   
               
               
                 1542 
                 1072 
                 CGAGCUCAAGGUGGACGCCUC 
                 2316 
                 GGCGUCCACCUUGAGCUCGGG 
                 64.1 
                 49.1 
               
               
                   
               
               
                 1543 
                 1073 
                 GAGCUCAAGGUGGACGCCUCG 
                 2317 
                 AGGCGUCCACCUUGAGCUCGG 
                 68.9 
                 53.9 
               
               
                   
               
               
                 1544 
                 1074 
                 AGCUCAAGGUGGACGCCUCGG 
                 2318 
                 GAGGCGUCCACCUUGAGCUCG 
                 69.6 
                 54.6 
               
               
                   
               
               
                 1545 
                 1075 
                 GCUCAAGGUGGACGCCUCGGG 
                 2319 
                 CGAGGCGUCCACCUUGAGCUC 
                 62:3 
                 47.3 
               
               
                   
               
               
                 1546 
                 1076 
                 CUCAAGGUGGACGCGUCGGGC 
                 2320 
                 CCGAGGCGUCCACCUUGAGCU 
                 51.8 
                 36.8 
               
               
                   
               
               
                 1547 
                 1077 
                 UCAAGGUGGACGCCUCGGGCC 
                 2321 
                 CCCGAGGCGUCCACCUUGAGC 
                 42.4 
                 27.4 
               
               
                   
               
               
                 1548 
                 1078 
                 CAAGGUGGACGCCUCGGGCCC 
                 2322 
                 GCCCGAGGCGUCCACCUUGAG 
                 53.4 
                 38.4 
               
               
                   
               
               
                 1567 
                 1079 
                 CCCGAUGUCCCGACACGGCGG 
                 2323 
                 GCCGUGUCGGGACAUCGGGGC 
                 57.8 
                 42.8 
               
               
                   
               
               
                 1568 
                 1080 
                 CCGAUGUCCCGACACGGCGGC 
                 2324 
                 CGCCGUGUCGGGACAUCGGGG 
                 69.5 
                 54.5 
               
               
                   
               
               
                 1569 
                 1081 
                 CGAUGUCCCGACACGGCGGCG 
                 2325 
                 CCGCCGUGUCGGGACAUCGGG 
                 73.8 
                 58.8 
               
               
                   
               
               
                 1570 
                 1082 
                 GAUGUCCCGACACGGCGGCGU 
                 2326 
                 GCCGCCGUGUCGGGACAUCGG 
                 57 
                 42 
               
               
                   
               
               
                 1571 
                 1083 
                 AUGUCCCGACACGGCGGCGUC 
                 2327 
                 CGCCGCCGUGUCGGGACAUCG 
                 44.8 
                 29.8 
               
               
                   
               
               
                 1572 
                 1084 
                 UGUCCCGACACGGCGGCGUCG 
                 2328 
                 ACGCCGCCGUGUCGGGACAUC 
                 51.2 
                 36.2 
               
               
                   
               
               
                 1573 
                 1085 
                 GUCCCGACACGGCGGCGUCGG 
                 2329 
                 GACGCCGCCGUGUCGGGACAU 
                 60.6 
                 45.6 
               
               
                   
               
               
                 1574 
                 1086 
                 UCCCGACACGGCGGCGUCGGC 
                 2330 
                 CGACGCCGCCGUGUCGGGACA 
                 44.4 
                 29.4 
               
               
                   
               
               
                 1575 
                 1087 
                 CCCGACACGGCGGCGUCGGCU 
                 2331 
                 CCGACGCCGCCGUGUCGGGAC 
                 45.7 
                 30.7 
               
               
                   
               
               
                 1576 
                 1088 
                 CGGACACGGCGGCGUCGGCUA 
                 2332 
                 GCCGACGCCGCCGUGUCGGGA 
                 57 
                 42 
               
               
                   
               
               
                 1577 
                 1089 
                 CGACACGGCGGCGUCGGCUAC 
                 2333 
                 AGCGGACGCCGCCGUGUCGGG 
                 64.3 
                 49.3 
               
               
                   
               
               
                 1578 
                 1090 
                 GACACGGCGGCGUCGGCUACA 
                 2334 
                 UAGCCGACGCCGCCGUGUCGG 
                 84.8 
                 69.8 
               
               
                   
               
               
                 1579 
                 1091 
                 ACACGGCGGCGUCGGCUACAG 
                 2335 
                 GUAGCCGACGCCGCCGUGUCG 
                 60.7 
                 45.7 
               
               
                   
               
               
                 1580 
                 1092 
                 CACGGCGGCGUCGGCUACAGC 
                 2336 
                 UGUAGCCGACGCCGCCGUGUC 
                 64.8 
                 49.8 
               
               
                   
               
               
                 1581 
                 1093 
                 ACGGCGGCGUCGGCUACAGCU 
                 2337 
                 CUGUAGCCGACGCCGCCGUGU 
                 61.7 
                 46.7 
               
               
                   
               
               
                 1582 
                 1094 
                 CGGCGGCGUCGGCUACAGCUC 
                 2338 
                 GCUGUAGCCGACGCCGCCGUG 
                 64.6 
                 49.6 
               
               
                   
               
               
                 1583 
                 1095 
                 GGCGGCGUCGGCUACAGCUCC 
                 2339 
                 AGCUGUAGCCGACGCCGCCGU 
                 73.4 
                 58.4 
               
               
                   
               
               
                 1584 
                 1096 
                 GCGGCGUCGGCUACAGCUCCG 
                 2340 
                 GAGCUGUAGCCGACGCCGCCG 
                 69.6 
                 54.6 
               
               
                   
               
               
                 1585 
                 1097 
                 CGGCGUCGGCUACAGCUCCGG 
                 2341 
                 GGAGCUGUAGCCGACGCCGCC 
                 57.7 
                 42.7 
               
               
                   
               
               
                 1586 
                 1098 
                 GGCGUCGGCUACAGCUCCGGG 
                 2342 
                 CGGAGCUGUAGCCGACGCCGC 
                 61.1 
                 46.1 
               
               
                   
               
               
                 1587 
                 1099 
                 GCGUCGGCUACAGCUCCGGGC 
                 2343 
                 CCGGAGCUGUAGCCGACGCCG 
                 61.9 
                 46.9 
               
               
                   
               
               
                 1588 
                 1100 
                 CGUCGGCUACAGCUCCGGGCG 
                 2344 
                 CCCGGAGCUGUAGCCGACGCC 
                 53.9 
                 38.9 
               
               
                   
               
               
                 1889 
                 1101 
                 GUCGGCUACAGCUCCGGGCGG 
                 2345 
                 GCCCGGAGCUGUAGCCGACGC 
                 45.7 
                 30.7 
               
               
                   
               
               
                 1590 
                 1102 
                 UCGGCUACAGCUCCGGGCGGC 
                 2346 
                 CGCCCGGAGCUGUAGCCGACG 
                 46.9 
                 31.9 
               
               
                   
               
               
                 1591 
                 1103 
                 CGGCUACAGCUCCGGGCGGCC 
                 2347 
                 CCGCCCGGAGCUGUAGCCGAC 
                 54.9 
                 39.9 
               
               
                   
               
               
                 1592 
                 1104 
                 GGCUACAGCUCCGGGCGGCCA 
                 2348 
                 GCCGCCCGGAGCUGUAGCCGA 
                 54.2 
                 39.2 
               
               
                   
               
               
                 1593 
                 1105 
                 GCUACAGCUCCGGGCGGCCAC 
                 2349 
                 GGCCGCCCGGAGCUGUAGCCG 
                 51 
                 36 
               
               
                   
               
               
                 1625 
                 1106 
                 AAACGGCCGCACUGGGACACG 
                 2350 
                 UGUCCCAGUGCGGCCGUUUUC 
                 63 
                 47 
               
               
                   
               
               
                 1626 
                 1107 
                 AACGGCCGCACUGGGACACGA 
                 2351 
                 GUGUCCCAGUGCGGCCGUUUU 
                 46.3 
                 30.3 
               
               
                   
               
               
                 1627 
                 1108 
                 ACGGCCGCACUGGGACACGAC 
                 2352 
                 CGUGUCCCAGUGCGGCCGUUU 
                 46.2 
                 30.2 
               
               
                   
               
               
                 1625 
                 1109 
                 CGGCCGCACUGGGACACGACC 
                 2353 
                 UCGUGUCCCAGUGCGGCCGUU 
                 61.7 
                 65.7 
               
               
                   
               
               
                 1629 
                 1110 
                 GGCCGCACUGGGACACGACCU 
                 2354 
                 GUCGUGUCCCAGUGCGGCCGU 
                 66.1 
                 50.1 
               
               
                   
               
               
                 1630 
                 1111 
                 GCCGCACUGGGACACGACCUG 
                 2355 
                 GGUCGUGUCCCAGUGCGGCCG 
                 62.2 
                 46.2 
               
               
                   
               
               
                 1631 
                 1112 
                 CCGCACUGGGACACGACCUGG 
                 2356 
                 AGGUCGUGUCCCAGUGCGGCC 
                 63.3 
                 47.3 
               
               
                   
               
               
                 1632 
                 1113 
                 CGCACUGGGACACGACCUGGA 
                 2357 
                 CAGGUCGUGUCCCAGUGCGGC 
                 66.3 
                 50.3 
               
               
                   
               
               
                 1633 
                 1114 
                 GCACUGGGACACGACCUGGAC 
                 2358 
                 CCAGGUCGUGUCCCAGUGCGG 
                 67.9 
                 51.9 
               
               
                   
               
               
                 1634 
                 1115 
                 CACUGGGACACGACCUGGACG 
                 2359 
                 UCCAGGUCGUGUCCGAGUGCG 
                 81.8 
                 65.8 
               
               
                   
               
               
                 1635 
                 1116 
                 ACUGGGACACGACCUGGACGG 
                 2360 
                 GUCCAGGUCGUGUCCCAGUGC 
                 61.1 
                 45.1 
               
               
                   
               
               
                 1636 
                 1117 
                 CUGGGACACGACCUGGACGGG 
                 2361 
                 CGUCCAGGUCGUGUCCCAGUG 
                 63 
                 47 
               
               
                   
               
               
                 1637 
                 1118 
                 UGGGACACGACCUGGACGGGC 
                 2362 
                 CCGUCCAGGUCGUGUCCCAGU 
                 54.4 
                 38.4 
               
               
                   
               
               
                 1638 
                 1119 
                 GGGACACGACCUGGACGGGCA 
                 2363 
                 CCCGUCCAGGUCGUGUCCCAG 
                 63.3 
                 47.3 
               
               
                   
               
               
                 1639 
                 1120 
                 GGACACGACCUGGACGGGCAG 
                 2364 
                 GCCCGUCCAGGUCGUGUCCCA 
                 55.4 
                 39.4 
               
               
                   
               
               
                 1640 
                 1121 
                 GACACGACCUGGACGGGCAGG 
                 2365 
                 UGCCCGUCCAGGUCGUGUCCC 
                 74.5 
                 58.5 
               
               
                   
               
               
                 1641 
                 1122 
                 ACACGACCUGGACGGGCAGGA 
                 2366 
                 CUGCCCGUCCAGGUCGUGUCC 
                 57.4 
                 41.4 
               
               
                   
               
               
                 1642 
                 1123 
                 CACGACCUGGACGGGCAGGAC 
                 2367 
                 CCUGCCCGUCCAGGUCGUGUC 
                 47.7 
                 31.7 
               
               
                   
               
               
                 1643 
                 1124 
                 ACGACCUGGACGGGCAGGACG 
                 2368 
                 UCCUGCCCGUCCAGGUCGUGU 
                 66.3 
                 50.3 
               
               
                   
               
               
                 1644 
                 1125 
                 CGACCUGGACGGGCAGGACGC 
                 2369 
                 GUCCUGCCCGUCCAGGUCGUG 
                 69.4 
                 53.4 
               
               
                   
               
               
                 1645 
                 1126 
                 GACCUGGACGGGCAGGACGCG 
                 2370 
                 CGUCCUGCCCGUCCAGGUCGU 
                 62 
                 46 
               
               
                   
               
               
                 1646 
                 1127 
                 ACCUGGACGGGCAGGACGCGG 
                 2371 
                 GCGUCCUGCCCGUCCAGGUCG 
                 52.3 
                 36.3 
               
               
                   
               
               
                 1647 
                 1128 
                 CCUGGACGGGCAGGACGCGGA 
                 2372 
                 CGCGUCCUGCCCGUCCAGGUC 
                 49.1 
                 33.1 
               
               
                   
               
               
                 1648 
                 1129 
                 CUGGACGGGCAGGACGCGGAU 
                 2373 
                 CCGCGUCCUGCCCGUCCAGGU 
                 49.1 
                 33.1 
               
               
                   
               
               
                 1649 
                 1130 
                 UGGACGGGCAGGACGCGGAUG 
                 2374 
                 UCCGCGUCCUGCCCGUCCAGG 
                 68.8 
                 52.8 
               
               
                   
               
               
                 1650 
                 1131 
                 GGACGGGCAGGACGCGGAUGA 
                 2375 
                 AUCCGCGUCCUGCCCGUCCAG 
                 82.1 
                 66.1 
               
               
                   
               
               
                 1651 
                 1132 
                 GACGGGCAGGACGCGGAUGAG 
                 2376 
                 CAUCCGCGUCCUGCCCGUCCA 
                 60.5 
                 44.5 
               
               
                   
               
               
                 1652 
                 1133 
                 ACGGGCAGGACGCGGAUGAGG 
                 2377 
                 UCAUCCGCGUCCUGCCCGUCC 
                 61.8 
                 45.8 
               
               
                   
               
               
                 1653 
                 1134 
                 CGGGCAGGACGCGGAUGAGGA 
                 2378 
                 CUCAUCCGCGUCCUGCCCGUC 
                 62 
                 46 
               
               
                   
               
               
                 1654 
                 1135 
                 GGGCAGGACGCGGAUGAGGAU 
                 2379 
                 CCUCAUCCGCGUCCUGCCCGU 
                 61.4 
                 45.4 
               
               
                   
               
               
                 1655 
                 1136 
                 GGCAGGACGCGGAUGAGGAUG 
                 2380 
                 UCCUCAUCCGCGUCCUGCCCG 
                 81.5 
                 65.5 
               
               
                   
               
               
                 1656 
                 1137 
                 GCAGGACGCGGAUGAGGAUGC 
                 2381 
                 AUCCUCAUCCGCGUCCUGCCC 
                 76.3 
                 60.3 
               
               
                   
               
               
                 1657 
                 1138 
                 CAGGACGCGGAUGAGGAUGCC 
                 2382 
                 CAUCCUCAUCCGCGUCCUGCC 
                 54.5 
                 38.5 
               
               
                   
               
               
                 1658 
                 1139 
                 AGGACGCGGAUGAGGAUGCCA 
                 2383 
                 GCAUCCUCAUCCGCGUCCUGC 
                 54.7 
                 38.7 
               
               
                   
               
               
                 1059 
                 1140 
                 GGACGCGGAUGAGGAUGCCAG 
                 2384 
                 GGCAUCCUCAUCCGCGUCCUG 
                 64.7 
                 48.7 
               
               
                   
               
               
                 1692 
                 1141 
                 GGGACAGCAGUAUGCAGAUGA 
                 2385 
                 AUCUGCAUACUGCUGUCCCCC 
                 80.6 
                 64.6 
               
               
                   
               
               
                 1693 
                 1142 
                 GGACAGCAGUAUGCAGAUGAC 
                 2386 
                 CAUCUGCAUACUGCUGUCCCC 
                 72.5 
                 56.5 
               
               
                   
               
               
                 1694 
                 1143 
                 GACAGCAGUAUGCAGAUGACU 
                 2387 
                 UCAUCUGCAUACUGCUGUCCC 
                 76.4 
                 62.4 
               
               
                   
               
               
                 1695 
                 1144 
                 ACAGCAGUAUGCAGAUGACUG 
                 2388 
                 GUCAUCUGCAUACUGCUGUCC 
                 67.7 
                 51.7 
               
               
                   
               
               
                 1696 
                 1145 
                 CAGCAGUAUGCAGAUGACUGG 
                 2389 
                 AGUCAUCUGCAUACUGCUGUC 
                 74.6 
                 58.6 
               
               
                   
               
               
                 1697 
                 1146 
                 AGCAGUAUGCAGAUGACUGGA 
                 2390 
                 CAGUCAUCUGCAUACUGCUGU 
                 75.1 
                 59.1 
               
               
                   
               
               
                 1698 
                 1147 
                 GCAGUAUGCAGAUGACUGGAU 
                 2391 
                 CCAGUCAUCUGCAUACUGCUG 
                 77.4 
                 61.4 
               
               
                   
               
               
                 1699 
                 1148 
                 CAGUAUGCAGAUGACUGGAUG 
                 2392 
                 UCCAGUCAUCUGCAUACUGCU 
                 82.8 
                 66.8 
               
               
                   
               
               
                 1700 
                 1149 
                 AGUAUGCAGAUGACUGGAUGG 
                 2393 
                 AUCCAGUCAUCUGCAUACUGC 
                 75.8 
                 58.8 
               
               
                   
               
               
                 1737 
                 1150 
                 CCCAGCCCGGCCUCCUCGGCC 
                 2394 
                 CCGAGGAGGCCGGGCUGGGGG 
                 49.7 
                 32.7 
               
               
                   
               
               
                 1738 
                 1151 
                 CCAGCCCGGCCUCCUCGGCCU 
                 2395 
                 GCCGAGGAGGCCGGGCUGGGG 
                 45.9 
                 28.9 
               
               
                   
               
               
                 1739 
                 1152 
                 CAGCCCGGCCUCCUCGGCCUC 
                 2396 
                 GGCCGAGGAGGCCGGGCUGGG 
                 40.7 
                 21.7 
               
               
                   
               
               
                 1740 
                 1153 
                 AGCCCGGCCUCCUCGGCCUCC 
                 2397 
                 AGGCCGAGGAGGCCGGGCUGG 
                 61.3 
                 44.3 
               
               
                   
               
               
                 1741 
                 1154 
                 GCCCGGCCUCCUCGGCCUCCA 
                 2398 
                 GAGGCCGAGGAGGCCGGGCUG 
                 57.4 
                 40.4 
               
               
                   
               
               
                 1742 
                 1155 
                 CCCGGCCUCCUCGGCCUCCAU 
                 2399 
                 GGAGGCCGAGGAGGCCGGGCU 
                 38.8 
                 21.8 
               
               
                   
               
               
                 1743 
                 1156 
                 CCGGCCUCCUCGGCCUCCAUA 
                 2400 
                 UGGAGGCCGAGGAGGCCGGGC 
                 61.9 
                 44.9 
               
               
                   
               
               
                 1744 
                 1157 
                 CGGCCUCCUCGGCCUCCAUAC 
                 2401 
                 AUGGAGGCCGAGGAGGCCGGG 
                 76.2 
                 59.2 
               
               
                   
               
               
                 1745 
                 1158 
                 GGCCUCCUCGGCCUCCAUACC 
                 2402 
                 UAUGGAGGCCGAGGAGGCCGG 
                 76.6 
                 59.6 
               
               
                   
               
               
                 1746 
                 1159 
                 GCCUCCUCGGCCUCCAUACCC 
                 2403 
                 GUAUGGAGGCCGAGGAGGCCG 
                 60.5 
                 43.5 
               
               
                   
               
               
                 1747 
                 1160 
                 CCUCCUCGGCCUCCAUACCCU 
                 2404 
                 GGUAUGGAGGCCGAGGAGGCC 
                 49.3 
                 32.3 
               
               
                   
               
               
                 1748 
                 1161 
                 CUCCUCGGCCUCCAUACCCUC 
                 2405 
                 GGGUAUGGAGGCCGAGGAGGC 
                 40 
                 23 
               
               
                   
               
               
                 1749 
                 1162 
                 UCCUCGGCCUCCAUACCCUCC 
                 2406 
                 AGGGUAUGGAGGCCGAGGAGG 
                 59.5 
                 42.5 
               
               
                   
               
               
                 1750 
                 1163 
                 CCUCGGCCUCCAUACCCUCCU 
                 2407 
                 GAGGGUAUGGAGGCCGAGGAG 
                 63.5 
                 46.5 
               
               
                   
               
               
                 1751 
                 1164 
                 CUCGGCCUCCAUACCCUCCUA 
                 2408 
                 GGAGGGUAUGGAGGCCGAGGA 
                 48.1 
                 31.1 
               
               
                   
               
               
                 1752 
                 1165 
                 UCGGCCUCCAUACCCUCCUAG 
                 2409 
                 AGGAGGGUAUGGAGGCCGAGG 
                 55.6 
                 38.6 
               
               
                   
               
               
                 1753 
                 1166 
                 CGGCCUCCAUACCCUCCUAGA 
                 2410 
                 UAGGAGGGUAUGGAGGCCGAG 
                 88.9 
                 71.9 
               
               
                   
               
               
                 1754 
                 1167 
                 GGCCUCCAUACCCUCCUAGAA 
                 2411 
                 CUAGGAGGGUAUGGAGGCCGA 
                 63.7 
                 46.7 
               
               
                   
               
               
                 1755 
                 1168 
                 GCCUCCAUACCCUCCUAGAAG 
                 2412 
                 UCUAGGAGGGUAUGGAGGCCG 
                 81.7 
                 64.7 
               
               
                   
               
               
                 1756 
                 1169 
                 CCUCCAUACCCUCCUAGAAGG 
                 2413 
                 UUCUAGGAGGGUAUGGAGGCC 
                 81.5 
                 64.5 
               
               
                   
               
               
                 1757 
                 1170 
                 CUCCAUACCCUCCUAGAAGGG 
                 2414 
                 CUUCUAGGAGGGUAUGGAGGC 
                 60.2 
                 43.2 
               
               
                   
               
               
                 1758 
                 1171 
                 UCCAUACCCUCCUAGAAGGGA 
                 2415 
                 CCUUCUAGGAGGGUAUGGAGG 
                 58.9 
                 41.9 
               
               
                   
               
               
                 1759 
                 1172 
                 CCAUACCCUCCUAGAAGGGAU 
                 2416 
                 CCCUUCUAGGAGGGUAUGGAG 
                 59 
                 42 
               
               
                   
               
               
                 1760 
                 1173 
                 CAUACCCUCCUAGAAGGGAUG 
                 2417 
                 UCCCUUCUAGGAGGGUAUGGA 
                 71.2 
                 54.2 
               
               
                   
               
               
                 1761 
                 1174 
                 AUACCCUCCUAGAAGGGAUGG 
                 2418 
                 AUCCCUUCUAGGAGGGUAUGG 
                 73.4 
                 56.4 
               
               
                   
               
               
                 1762 
                 1175 
                 UACCCUCCUAGAAGGGAUGGU 
                 2419 
                 CAUCCCUUCUAGGAGGGUAUG 
                 61 
                 44 
               
               
                   
               
               
                 1763 
                 1176 
                 ACCCUCCUAGAAGGGAUGGUU 
                 2420 
                 CCAUCCCUUCUAGGAGGGUAU 
                 50.2 
                 33.2 
               
               
                   
               
               
                 1764 
                 1177 
                 CCCUCCUAGAAGGGAUGGUUC 
                 2421 
                 ACCAUCCCUUCUAGGAGGGUA 
                 68.6 
                 51.6 
               
               
                   
               
               
                 1765 
                 1178 
                 CCUCCUAGAAGGGAUGGUUCU 
                 2422 
                 AACCAUCCCUUCUAGGAGGGU 
                 80 
                 63 
               
               
                   
               
               
                 1766 
                 1179 
                 CUCCUAGAAGGGAUGGUUCUG 
                 2423 
                 GAACCAUCCCUUCUAGGAGGG 
                 68.3 
                 51.3 
               
               
                   
               
               
                 1767 
                 1180 
                 UCCUAGAAGGGAUGGUUCUGG 
                 2424 
                 AGAACCAUCCCUUCUAGGAGG 
                 73.5 
                 56.5 
               
               
                   
               
               
                 1768 
                 1181 
                 CCUAGAAGGGAUGGUUCUGGG 
                 2425 
                 CAGAACCAUCCCUUCUAGGAG 
                 72.6 
                 55.6 
               
               
                   
               
               
                 1804 
                 1182 
                 GGCAGUGCCCGCUACAACCAG 
                 2426 
                 GGUUGUAGCGGGCACUGCCAC 
                 60 
                 42 
               
               
                   
               
               
                 1805 
                 1183 
                 GCAGUGCCCGCUACAACCAGG 
                 2427 
                 UGGUUGUAGCGGGCACUGCCA 
                 79.5 
                 61.5 
               
               
                   
               
               
                 1806 
                 1184 
                 CAGUGCCCGCUACAACCAGGG 
                 2428 
                 CUGGUUGUAGCGGGCACUGCC 
                 59.4 
                 41.4 
               
               
                   
               
               
                 1807 
                 1185 
                 AGUGCCCGCUACAACCAGGGC 
                 2429 
                 CCUGGUUGUAGCGGGCACUGC 
                 56 
                 38 
               
               
                   
               
               
                 1808 
                 1186 
                 GUGCCCGCUACAACCAGGGCC 
                 2430 
                 CCCUGGUUGUAGCGGGCACUG 
                 53.7 
                 35.7 
               
               
                   
               
               
                 1809 
                 1187 
                 UGCCCGCUACAACCAGGGCCG 
                 2431 
                 GCCCUGGUUGUAGCGGGCACU 
                 44.1 
                 26.1 
               
               
                   
               
               
                 1810 
                 1188 
                 GCCCGCUACAACCAGGGCCGG 
                 2432 
                 GGCCCUGGUUGUAGCGGGCAC 
                 43 
                 25 
               
               
                   
               
               
                 1811 
                 1189 
                 CCCGCUACAACCAGGGCCGGA 
                 2433 
                 CGGCCCUGGUUGUAGCGGGCA 
                 52.2 
                 34.2 
               
               
                   
               
               
                 1812 
                 1190 
                 CCGCUACAACCAGGGCCGGAG 
                 2434 
                 CCGGCCCUGGUUGUAGCGGGC 
                 47.8 
                 29.8 
               
               
                   
               
               
                 1813 
                 1191 
                 CGCUACAACCAGGGCCGGAGC 
                 2435 
                 UCCGGCCCUGGUUGUAGCGGG 
                 71.9 
                 53.9 
               
               
                   
               
               
                 1814 
                 1192 
                 GCUACAACCAGGGCCGGAGCA 
                 2436 
                 CUCCGGCCCUGGUUGUAGCGG 
                 62.6 
                 44.6 
               
               
                   
               
               
                 1815 
                 1193 
                 CUACAACCAGGGCCGGAGCAG 
                 2437 
                 GCUCCGGCCCUGGUUGUAGCG 
                 50.9 
                 32.9 
               
               
                   
               
               
                 1816 
                 1194 
                 UACAACCAGGGCCGGAGCAGG 
                 2438 
                 UGCUCCGGCCCUGGUUGUAGC 
                 50.2 
                 32.2 
               
               
                   
               
               
                 1817 
                 1195 
                 ACAACCAGGGCCGGAGCAGGA 
                 2439 
                 CUGCUCCGGCCCUGGUUGUAG 
                 50.3 
                 32.3 
               
               
                   
               
               
                 1818 
                 1196 
                 CAACCAGGGCCGGAGCAGGAG 
                 2440 
                 CCUGCUCCGGCCCUGGUUGUA 
                 54 
                 36 
               
               
                   
               
               
                 1819 
                 1197 
                 AACCAGGGCCGGAGCAGGAGU 
                 2441 
                 UCCUGCUCCGGCCCUGGUUGU 
                 65.5 
                 47.5 
               
               
                   
               
               
                 1820 
                 1198 
                 ACCAGGGCCGGAGCAGGAGUG 
                 2442 
                 CUCCUGCUCCGGCCCUGGUUG 
                 52.7 
                 34.7 
               
               
                   
               
               
                 1821 
                 1199 
                 CCAGGGCCGGAGCAGGAGUGG 
                 2443 
                 ACUCCUGCUCCGGCCCUGGUU 
                 68.3 
                 50.3 
               
               
                   
               
               
                 1822 
                 1200 
                 CAGGGCCGGAGCAGGAGUGGG 
                 2444 
                 CACUCCUGCUCCGGCCCUGGU 
                 57.3 
                 39.3 
               
               
                   
               
               
                 1858 
                 1201 
                 UUUCACACCCAAACCAUCCUC 
                 2445 
                 GGAUGGUUUGGGUGUGAAAAC 
                 36.4 
                 18.4 
               
               
                   
               
               
                 1859 
                 1202 
                 UUCACACCCAAACCAUCCUCA 
                 2446 
                 AGGAUGGUUUGGGUGUGAAAA 
                 56.8 
                 38.8 
               
               
                   
               
               
                 1860 
                 1203 
                 UCACACCCAAACCAUCCUCAU 
                 2447 
                 GAGGAUGGUUUGGGUGUGAAA 
                 50.9 
                 32.9 
               
               
                   
               
               
                 1861 
                 1204 
                 CACACCCAAACCAUCCUCAUU 
                 2448 
                 UGAGGAUGGUUUGGGUGUGAA 
                 71.6 
                 53.6 
               
               
                   
               
               
                 1862 
                 1205 
                 ACACCCAAACCAUCCUCAUUC 
                 2449 
                 AUGAGGAUGGUUUGGGUGUGA 
                 74.3 
                 56.3 
               
               
                   
               
               
                 1863 
                 1206 
                 CACCCAAACCAUCCUCAUUCU 
                 2450 
                 AAUGAGGAUGGUUUGGGUGUG 
                 80.4 
                 62.4 
               
               
                   
               
               
                 1864 
                 1207 
                 ACCCAAACCAUCCUCAUUCUC 
                 2451 
                 GAAUGAGGAUGGUUUGGGUGU 
                 57.7 
                 39.7 
               
               
                   
               
               
                 1865 
                 1208 
                 CCCAAACCAUCCUCAUUCUCU 
                 2452 
                 AGAAUGAGGAUGGUUUGGGUG 
                 78 
                 60 
               
               
                   
               
               
                 1866 
                 1209 
                 CCAAACCAUCCUCAUUCUCUC 
                 2453 
                 GAGAAUGAGGAUGGUUUGGGU 
                 65.4 
                 47.4 
               
               
                   
               
               
                 1867 
                 1210 
                 CAAACCAUCCUCAUUCUCUCC 
                 2454 
                 AGAGAAUGAGGAUGGUUUGGG 
                 70.5 
                 52.5 
               
               
                   
               
               
                 1868 
                 1211 
                 AAACCAUCCUCAUUCUCUCCC 
                 2455 
                 GAGAGAAUGAGGAUGGUUUGG 
                 66.7 
                 48.7 
               
               
                   
               
               
                 1869 
                 1212 
                 AACCAUCCUCAUUCUCUCCCU 
                 2456 
                 GGAGAGAAUGAGGAUGGUUUG 
                 57.3 
                 39.3 
               
               
                   
               
               
                 1870 
                 1213 
                 ACCAUCCUCAUUCUCUCCCUC 
                 2457 
                 GGGAGAGAAUGAGGAUGGUUU 
                 46.4 
                 28.4 
               
               
                   
               
               
                 1871 
                 1214 
                 CCAUCCUCAUUCUCUCCCUCU 
                 2458 
                 AGGGAGAGAAUGAGGAUGGUU 
                 72.8 
                 54.8 
               
               
                   
               
               
                 1872 
                 1215 
                 CAUCCUCAUUCUCUCCCUCUC 
                 2459 
                 GAGGGAGAGAAUGAGGAUGGU 
                 66.2 
                 48.2 
               
               
                   
               
               
                 1873 
                 1216 
                 AUCCUCAUUCUCUCCCUCUCA 
                 2460 
                 AGAGGGAGAGAAUGAGGAUGG 
                 61 
                 43 
               
               
                   
               
               
                 1874 
                 1217 
                 UCCUCAUUCUCUCCCUCUCAG 
                 2461 
                 GAGAGGGAGAGAAUGAGGAUG 
                 64 
                 46 
               
               
                   
               
               
                 1875 
                 1218 
                 CCUCAUUCUCUCCCUCUCAGC 
                 2462 
                 UGAGAGGGAGAGAAUGAGGAU 
                 81.7 
                 63.7 
               
               
                   
               
               
                 1876 
                 1219 
                 CUCAUUCUCUCCCUCUCAGCC 
                 2463 
                 CUGAGAGGGAGAGAAUGAGGA 
                 66.7 
                 48.7 
               
               
                   
               
               
                 1877 
                 1220 
                 UCAUUCUCUCCCUCUCAGCCC 
                 2464 
                 GCUGAGAGGGAGAGAAUGAGG 
                 52.2 
                 34.2 
               
               
                   
               
               
                 1878 
                 1221 
                 CAUUCUCUCCCUCUCAGCCCU 
                 2465 
                 GGCUGAGAGGGAGAGAAUGAG 
                 56.3 
                 38.3 
               
               
                   
               
               
                 1879 
                 1222 
                 AUUCUCUCCCUCUCAGCCCUG 
                 2466 
                 GGGCUGAGAGGGAGAGAAUGA 
                 44 
                 26 
               
               
                   
               
               
                 1880 
                 1223 
                 UUCUCUCCCUCUCAGCCCUGG 
                 2467 
                 AGGGCUGAGAGGGAGAGAAUG 
                 60 
                 42 
               
               
                   
               
               
                 1899 
                 1224 
                 GGCCCUGCUUGGACCUCGAUA 
                 2468 
                 UCGAGGUCCAAGCAGGGCCAG 
                 89.2 
                 71.2 
               
               
                   
               
               
                 1900 
                 1225 
                 GCCCUGCUUGGACCUCGAUAA 
                 2469 
                 AUCGAGGUCCAAGCAGGGCCA 
                 78.2 
                 59.2 
               
               
                   
               
               
                 1901 
                 1226 
                 CCCUGCUUGGACCUCGAUAAC 
                 2470 
                 UAUCGAGGUCCAAGCAGGGCC 
                 77.8 
                 58.8 
               
               
                   
               
               
                 1902 
                 1227 
                 CCUGCUUGGACCUCGAUAACG 
                 2471 
                 UUAUCGAGGUCCAAGCAGGGC 
                 88.4 
                 69.4 
               
               
                   
               
               
                 1903 
                 1228 
                 CUGCUUGGACCUGGAUAACGG 
                 2472 
                 GUUAUCGAGGUCCAAGCAGGG 
                 72.3 
                 53.3 
               
               
                   
               
               
                 1904 
                 1229 
                 UGCUUGGACCUCGAUAACGGG 
                 2473 
                 CGUUAUCGAGGUCCAAGCAGG 
                 59.1 
                 40.1 
               
               
                   
               
               
                 1929 
                 1230 
                 GGGUGCCCUAGCAUCAGAAGG 
                 2474 
                 UUCUGAUGCUAGGGCACCCCU 
                 83.4 
                 64.4 
               
               
                   
               
               
                 1930 
                 1231 
                 GGUGCCCUAGCAUCAGAAGGG 
                 2475 
                 CUUCUGAUGCUAGGGCACCCC 
                 66.1 
                 47.1 
               
               
                   
               
               
                 1931 
                 1232 
                 GUGCCCUAGCAUCAGAAGGGU 
                 2476 
                 CCUUCUGAUGCUAGGGCACCC 
                 54.8 
                 35.8 
               
               
                   
               
               
                 1932 
                 1233 
                 UGCCCUAGCAUCAGAAGGGUU 
                 2477 
                 CCCUUCUGAUGCUAGGGCACC 
                 44.4 
                 25.4 
               
               
                   
               
               
                 1933 
                 1234 
                 GCCCUAGCAUCAGAAGGGUUC 
                 2478 
                 ACCCUUCUGAUGCUAGGGCAC 
                 65.7 
                 46.7 
               
               
                   
               
               
                 1934 
                 1235 
                 CCCUAGCAUCAGAAGGGUUCA 
                 2479 
                 AACCCUUCUGAUGCUAGGGCA 
                 79.8 
                 60.8 
               
               
                   
               
               
                 1935 
                 1236 
                 CCUAGCAUCAGAAGGGUUCAU 
                 2480 
                 GAACCCUUCUGAUGCUAGGGC 
                 63.1 
                 44.1 
               
               
                   
               
               
                 1936 
                 1237 
                 CUAGCAUCAGAAGGGUUCAUG 
                 2481 
                 UGAACCCUUCUGAUGCUAGGG 
                 84.6 
                 65.6 
               
               
                   
               
               
                 1937 
                 1238 
                 UAGCAUCAGAAGGGUUCAUGG 
                 2482 
                 AUGAACCCUUCUGAUGCUAGG 
                 72.2 
                 53.2 
               
               
                   
               
               
                 2006 
                 1239 
                 GGGCUGCAGAGAGGGUAGAGA 
                 2483 
                 UCUACCCUCUCUGCAGCCCCC 
                 73.3 
                 53.3 
               
               
                   
               
               
                 2007 
                 1240 
                 GGCUGCAGAGAGGGUAGAGAA 
                 2484 
                 CUCUACCCUCUCUGCAGCCCC 
                 60.5 
                 40.5 
               
               
                   
               
               
                 2008 
                 1241 
                 GCUGCAGAGAGGGUAGAGAAG 
                 2485 
                 UCUCUACCCUCUCUGCAGCCC 
                 75.2 
                 55.2 
               
               
                   
               
               
                 2009 
                 1242 
                 CUGCAGAGAGGGUAGAGAAGG 
                 2486 
                 UUCUCUACCCUCUCUGCAGCC 
                 80.6 
                 60.6 
               
               
                   
               
               
                 2010 
                 1243 
                 UGCAGAGAGGGUAGAGAAGGG 
                 2487 
                 CUUCUCUACCCUCUCUGCAGC 
                 62.7 
                 42.7 
               
               
                   
               
               
                 2011 
                 1244 
                 GCAGAGAGGGUAGAGAAGGGA 
                 2488 
                 CCUUCUCUACCCUCUCUGCAG 
                 67.6 
                 47.6 
               
               
                   
               
               
                 2012 
                 1245 
                 CAGAGAGGGUAGAGAAGGGAC 
                 2489 
                 CCCUUCUCUACCCUCUCUGCA 
                 64.4 
                 44.4 
               
               
                   
               
               
                 2013 
                 1246 
                 AGAGAGGGUAGAGAAGGGACU 
                 2490 
                 UCCCUUCUCUACCCUCUCUGC 
                 70.2 
                 50.2 
               
               
                   
               
               
                 2014 
                 1247 
                 GAGAGGGUAGAGAAGGGACUU 
                 2491 
                 GUCCCUUCUCUACCCUCUCUG 
                 71.7 
                 51.7 
               
               
                   
               
               
                 2015 
                 1248 
                 AGAGGGUAGAGAAGGGACUUU 
                 2492 
                 AGUCCCUUCUCUACCCUCUCU 
                 72.8 
                 52.8 
               
               
                   
               
               
                 2016 
                 1249 
                 GAGGGUAGAGAAGGGACUUUG 
                 2493 
                 AAGUCCCUUCUCUACCCUCUC 
                 73.6 
                 53.6 
               
               
                   
               
               
                 2017 
                 1250 
                 AGGGUAGAGAAGGGACUUUGC 
                 2494 
                 AAAGUCCCUUCUCUACCCUCU 
                 71.3 
                 51.3 
               
               
                   
               
               
                 2018 
                 1251 
                 GGGUAGAGAAGGGACUUUGCA 
                 2495 
                 CAAAGUCCCUUCUCUACCCUC 
                 69.2 
                 49.2 
               
               
                   
               
               
                 2019 
                 1252 
                 GGUAGAGAAGGGACUUUGCAG 
                 2496 
                 GCAAAGUCCCUUCUCUACCCU 
                 70.7 
                 50.7 
               
               
                   
               
               
                 2020 
                 1253 
                 GUAGAGAAGGGACUUUGCAGG 
                 2497 
                 UGCAAAGUCCCUUCUCUACCC 
                 72.2 
                 52.2 
               
               
                   
               
               
                 2021 
                 1254 
                 UAGAGAAGGGACUUUGCAGGU 
                 2498 
                 CUGCAAAGUCCCUUCUCUACC 
                 52.8 
                 32.8 
               
               
                   
               
               
                 2022 
                 1255 
                 AGAGAAGGGACUUUGCAGGUG 
                 2499 
                 CCUGCAAAGUCCCUUCUCUAC 
                 54.7 
                 34.7 
               
               
                   
               
               
                 2023 
                 1256 
                 GAGAAGGGACUUUGCAGGUGA 
                 2500 
                 ACCUGCAAAGUCCCUUCUCUA 
                 74.3 
                 54.3 
               
               
                   
               
               
                 2024 
                 1257 
                 AGAAGGGACUUUGCAGGUGAA 
                 2501 
                 CACCUGCAAAGUCCCUUCUCU 
                 62.1 
                 42.1 
               
               
                   
               
               
                 2025 
                 1258 
                 GAAGGGACUUUGCAGGUGAAU 
                 2502 
                 UCACCUGCAAAGUCCCUUCUC 
                 81 
                 61 
               
               
                   
               
               
                 2026 
                 1259 
                 AAGGGACUUUGCAGGUGAAUG 
                 2503 
                 UUCACCUGCAAAGUCCCUUCU 
                 82.9 
                 62.9 
               
               
                   
               
               
                 2027 
                 1260 
                 AGGGACUUUGCAGGUGAAUGG 
                 2504 
                 AUUCACCUGCAAAGUCCCUUC 
                 66.8 
                 46.8 
               
               
                   
               
               
                 2071 
                 1261 
                 UUUCAUCAGAGGUGGGUGGGU 
                 2505 
                 CCACCCACCUCUGAUGAAAAU 
                 47.7 
                 27.7 
               
               
                   
               
               
                 2072 
                 1262 
                 UUCAUCAGAGGUGGGUGGGUG 
                 2506 
                 CCCACCCACCUCUGAUGAAAA 
                 35.6 
                 15.6 
               
               
                   
               
               
                 2073 
                 1263 
                 UCAUCAGAGGUGGGUGGGUGU 
                 2507 
                 ACCCACCCACCUCUGAUGAAA 
                 55 
                 35 
               
               
                   
               
               
                 2074 
                 1264 
                 CAUCAGAGGUGGGUGGGUGUU 
                 2508 
                 CACCCACCCACCUCUGAUGAA 
                 59.8 
                 39.8 
               
               
                   
               
               
                 2075 
                 1265 
                 AUCAGAGGUGGGUGGGUGUUC 
                 2509 
                 ACACCCACCCACCUCUGAUGA 
                 64.5 
                 44.5 
               
               
                   
               
               
                 2076 
                 1266 
                 UCAGAGGUGGGUGGGUGUUCA 
                 2510 
                 AACACCCACCCACCUCUGAUG 
                 68.4 
                 48.4 
               
               
                   
               
               
                 2077 
                 1267 
                 CAGAGGUGGGUGGGUGUUCAC 
                 2511 
                 GAACACCCACCCACCUCUGAU 
                 63.2 
                 43.2 
               
               
                   
               
               
                 2078 
                 1268 
                 AGAGGUGGGUGGGUGUUCACA 
                 2512 
                 UGAACACCCACCCACCUCUGA 
                 81.5 
                 61.5 
               
               
                   
               
               
                 2079 
                 1289 
                 GAGGUGGGUGGGUGUUCACAA 
                 2513 
                 GUGAACACCCACCCACCUCUG 
                 73.4 
                 53.4 
               
               
                   
               
               
                 2080 
                 1270 
                 AGGUGGGUGGGUGUUCACAAU 
                 2514 
                 UGUGAACACCCACCCACCUCU 
                 74 
                 54 
               
               
                   
               
               
                 2081 
                 1271 
                 GGUGGGUGGGUGUUCACAAUA 
                 2515 
                 UUGUGAACACCCACCCACCUC 
                 89.9 
                 69.9 
               
               
                   
               
               
                 2082 
                 1272 
                 GUGGGUGGGUGUUCACAAUAU 
                 2516 
                 AUUGUGAACACCCACCCACCU 
                 83.7 
                 63.7 
               
               
                   
               
               
                 2083 
                 1273 
                 UGGGUGGGUGUUCACAAUAUU 
                 2517 
                 UAUUGUGAACACCCACCCACC 
                 74.1 
                 54.1 
               
               
                   
               
               
                 2084 
                 1274 
                 GGGUGGGUGUUCACAAUAUUU 
                 2518 
                 AUAUUGUGAACACCCACCCAC 
                 87.2 
                 67.2 
               
               
                   
               
               
                 2085 
                 1275 
                 GGUGGGUGUUCACAAUAUUUA 
                 2519 
                 AAUAUUGUGAACACCCACCCA 
                 96.5 
                 76.5 
               
               
                   
               
               
                 2086 
                 1276 
                 GUGGGUGUUCACAAUAUUUAU 
                 2520 
                 AAAUAUUGUGAACACCCACCC 
                 79.8 
                 59.8 
               
               
                   
               
               
                 2087 
                 1277 
                 UGGGUGUUCACAAUAUUUAUU 
                 2521 
                 UAAAUAUUGUGAACACCCACC 
                 78.4 
                 58.4 
               
               
                   
               
               
                 2088 
                 1278 
                 GGGUGUUCACAAUAUUUAUUU 
                 2522 
                 AUAAAUAUUGUGAACACCCAC 
                 93.3 
                 73.3 
               
               
                   
               
               
                 2109 
                 1279 
                 UUUCAUUUGGUAAUGGGAGGG 
                 2523 
                 CUCCCAUUACCAAAUGAAAAA 
                 48.7 
                 27.7 
               
               
                   
               
               
                 2138 
                 1280 
                 GGGUAUUUAUUUAGGAGGGAG 
                 2524 
                 CCCUCCUAAAUAAAUACCCCC 
                 57.6 
                 36.6 
               
               
                   
               
               
                 2139 
                 1281 
                 GGUAUUUAUUUAGGAGGGAGU 
                 2525 
                 UCCCUCCUAAAUAAAUACCCC 
                 71.9 
                 50.9 
               
               
                   
               
               
                 2140 
                 1282 
                 GUAUUUAUUUAGGAGGGAGUG 
                 2526 
                 CUCCCUCCUAAAUAAAUACCC 
                 54.9 
                 33.9 
               
               
                   
               
               
                 2141 
                 1283 
                 UAUUUAUUUAGGAGGGAGUGU 
                 2527 
                 ACUCCCUCCUAAAUAAAUACC 
                 53.4 
                 32.4 
               
               
                   
               
               
                 2142 
                 1284 
                 AUUUAUUUAGGAGGGAGUGUG 
                 2528 
                 CACUCCCUCCUAAAUAAAUAC 
                 47.6 
                 26.6 
               
               
                   
               
               
                 2143 
                 1285 
                 UUUAUUUAGGAGGGAGUGUGG 
                 2529 
                 ACACUCCCUCCUAAAUAAAUA 
                 55.8 
                 34.8 
               
               
                   
               
               
                 2144 
                 1286 
                 UUAUUUAGGAGGGAGUGUGGU 
                 2530 
                 CACACUCCCUCCUAAAUAAAU 
                 50.4 
                 29.4 
               
               
                   
               
               
                 2145 
                 1287 
                 UAUUUAGGAGGGAGUGUGGUU 
                 2531 
                 CCACACUCCCUCCUAAAUAAA 
                 53 
                 32 
               
               
                   
               
               
                 2146 
                 1288 
                 AUUUAGGAGGGAGUGUGGUUU 
                 2532 
                 ACCACACUCCCUCCUAAAUAA 
                 58.1 
                 37.1 
               
               
                   
               
               
                 2147 
                 1289 
                 UUUAGGAGGGAGUGUGGUUUC 
                 2533 
                 AACCACACUCCCUCCUAAAUA 
                 65.9 
                 44.9 
               
               
                   
               
               
                 2148 
                 1290 
                 UUAGGAGGGAGUGUGGUUUCC 
                 2534 
                 AAACCACACUCCCUCCUAAAU 
                 60.8 
                 39.8 
               
               
                   
               
               
                 2149 
                 1291 
                 UAGGAGGGAGUGUGGUUUCCU 
                 2535 
                 GAAACCACACUCCCUCCUAAA 
                 59 
                 38 
               
               
                   
               
               
                 2150 
                 1292 
                 AGGAGGGAGUGUGGUUUCCUU 
                 2536 
                 GGAAACCACACUCCCUCCUAA 
                 61.2 
                 40.2 
               
               
                   
               
               
                 2151 
                 1293 
                 GGAGGGAGUGUGGUUUCCUUA 
                 2537 
                 AGGAAACCACACUCCCUCCUA 
                 76.7 
                 55.7 
               
               
                   
               
               
                 2152 
                 1294 
                 GAGGGAGUGUGGUUUCCUUAG 
                 2538 
                 AAGGAAACCACACUCCCUCCU 
                 83 
                 62 
               
               
                   
               
               
                 2153 
                 1295 
                 AGGGAGUGUGGUUUCCUUAGA 
                 2539 
                 UAAGGAAACCACACUCCCUCC 
                 79.6 
                 58.6 
               
               
                   
               
               
                 2154 
                 1296 
                 GGGAGUGUGGUUUCCUUAGAA 
                 2540 
                 CUAAGGAAACCACACUCCCUC 
                 74.3 
                 53.3 
               
               
                   
               
               
                 2155 
                 1297 
                 GGAGUGUGGUUUCCUUAGAAG 
                 2541 
                 UCUAAGGAAACCACACUCCCU 
                 94.3 
                 73.3 
               
               
                   
               
               
                 2156 
                 1298 
                 GAGUGUGGUUUCCUUAGAAGG 
                 2542 
                 UUGUAAGGAAACCACACUCCC 
                 88.3 
                 67.3 
               
               
                   
               
               
                 2157 
                 1299 
                 AGUGUGGUUUCCUUAGAAGGU 
                 2543 
                 CUUCUAAGGAAACCACACUCC 
                 68.6 
                 47.6 
               
               
                   
               
               
                 2158 
                 1300 
                 GUGUGGUUUCCUUAGAAGGUA 
                 2544 
                 CCUUCUAAGGAAACCACACUC 
                 67.8 
                 46.8 
               
               
                   
               
               
                 2159 
                 1301 
                 UGUGGUUUCCUUAGAAGGUAU 
                 2545 
                 ACCUUCUAAGGAAACCACACU 
                 71.6 
                 50.6 
               
               
                   
               
               
                 2160 
                 1302 
                 GUGGUUUCCUUAGAAGGUAUA 
                 2546 
                 UACCUUCUAAGGAAACCACAC 
                 81.1 
                 60.1 
               
               
                   
               
               
                 2161 
                 1303 
                 UGGUUUCCUUAGAAGGUAUAG 
                 2547 
                 AUACCUUCUAAGGAAACCACA 
                 80.6 
                 59.6 
               
               
                   
               
               
                 2162 
                 1304 
                 GGUUUCCUUAGAAGGUAUAGU 
                 2548 
                 UAUACCUUCUAAGGAAACCAC 
                 88.3 
                 67.3 
               
               
                   
               
               
                 2163 
                 1305 
                 GUUUCCUUAGAAGGUAUAGUC 
                 2549 
                 CUAUACCUUCUAAGGAAACCA 
                 67.3 
                 46.3 
               
               
                   
               
               
                 2164 
                 1306 
                 UUUCCUUAGAAGGUAUAGUCU 
                 2550 
                 ACUAUACCUUCUAAGGAAACC 
                 53.6 
                 32.6 
               
               
                   
               
               
                 2165 
                 1307 
                 UUCCUUAGAAGGUAUAGUCUC 
                 2551 
                 GACUAUACCUUCUAAGGAAAC 
                 51.5 
                 30.5 
               
               
                   
               
               
                 2166 
                 1308 
                 UCCUUAGAAGGUAUAGUCUCU 
                 2552 
                 AGACUAUACCUUCUAAGGAAA 
                 68.5 
                 47.5 
               
               
                   
               
               
                 2167 
                 1309 
                 CCUUAGAAGGUAUAGUCUCUA 
                 2553 
                 GAGACUAUACCUUCUAAGGAA 
                 75.3 
                 54.3 
               
               
                   
               
               
                 2168 
                 1310 
                 CUUAGAAGGUAUAGUCUCUAG 
                 2554 
                 AGAGACUAUACCUUCUAAGGA 
                 81.1 
                 60.1 
               
               
                   
               
               
                 2169 
                 1311 
                 UUAGAAGGUAUAGUCUCUAGG 
                 2555 
                 UAGAGACUAUACCUUCUAAGG 
                 76.8 
                 55.8 
               
               
                   
               
               
                 2170 
                 1312 
                 UAGAAGGUAUAGUCUCUAGCC 
                 2556 
                 CUAGAGACUAUACCUUCUAAG 
                 72.1 
                 51.1 
               
               
                   
               
               
                 2171 
                 1313 
                 AGAAGGUAUAGUCUCUAGCCC 
                 2557 
                 GCUAGAGACUAUACCUUCUAA 
                 67.9 
                 46.9 
               
               
                   
               
               
                 2172 
                 1314 
                 GAAGGUAUAGUCUCUAGCCCU 
                 2558 
                 GGCUAGAGACUAUACCUUCUA 
                 66.9 
                 45.9 
               
               
                   
               
               
                 2173 
                 1315 
                 AAGGUAUAGUCUCUAGCCCUC 
                 2559 
                 GGGCUAGAGACUAUACCUUCU 
                 56.4 
                 35.4 
               
               
                   
               
               
                 2174 
                 1316 
                 AGGUAUAGUCUCUAGCCCUCU 
                 2560 
                 AGGGCUAGAGACUAUACCUUC 
                 70.8 
                 49.8 
               
               
                   
               
               
                 2175 
                 1317 
                 GGUAUAGUCUCUAGCCCUCUA 
                 2561 
                 GAGGGCUAGAGACUAUACCUU 
                 76.1 
                 55.1 
               
               
                   
               
               
                 2176 
                 1318 
                 GUAUAGUCUCUAGCCCUCUAA 
                 2562 
                 AGAGGGCUAGAGACUAUACCU 
                 69.1 
                 48.1 
               
               
                   
               
               
                 2177 
                 1319 
                 UAUAGUCUCUAGCCCUCUAAG 
                 2563 
                 UAGAGGGCUAGAGACUAUACC 
                 74.9 
                 53.9 
               
               
                   
               
               
                 2178 
                 1320 
                 AUAGUCUCUAGCCCUCUAAGG 
                 2564 
                 UUAGAGGGCUAGAGACUAUAC 
                 71.3 
                 50.3 
               
               
                   
               
               
                 2179 
                 1321 
                 UAGUCUCUAGCCCUCUAAGGC 
                 2565 
                 CUUAGAGGGCUAGAGACUAUA 
                 63.7 
                 42.7 
               
               
                   
               
               
                 2180 
                 1322 
                 AGUCUCUAGCCCUCUAAGGCU 
                 2566 
                 CCUUAGAGGGCUAGAGACUAU 
                 61.3 
                 40.3 
               
               
                   
               
               
                 2181 
                 1323 
                 GUCUCUAGCCCUCUAAGGCUG 
                 2567 
                 GCCUUAGAGGGCUAGAGACUA 
                 57.6 
                 36.6 
               
               
                   
               
               
                 2182 
                 1324 
                 UCUCUAGCCCUCUAAGGCUGG 
                 2568 
                 AGCCUUAGAGGGCUAGAGACU 
                 59.5 
                 38.5 
               
               
                   
               
               
                 2183 
                 1325 
                 CUCUAGCCCUCUAAGGCUGGG 
                 2569 
                 CAGCCUUAGAGGGCUAGAGAC 
                 60.5 
                 39.5 
               
               
                   
               
               
                 2228 
                 1326 
                 AAAUGAGGAGUUUAGAGUUGC 
                 2570 
                 AACUCUAAACUCCUCAUUUUC 
                 76.1 
                 54.1 
               
               
                   
               
               
                 2229 
                 1327 
                 AAUGAGGAGUUUAGAGUUGCA 
                 2571 
                 CAACUCUAAACUCCUCAUUUU 
                 73.9 
                 51.9 
               
               
                   
               
               
                 2230 
                 1328 
                 AUGAGGAGUUUAGAGUUGCAG 
                 2572 
                 GCAACUCUAAACUCCUCAUUU 
                 62.3 
                 40.3 
               
               
                   
               
               
                 2231 
                 1329 
                 UGAGGAGUUUAGAGUUGCAGC 
                 2573 
                 UGCAACUCUAAACUCCUCAUU 
                 86.6 
                 64.6 
               
               
                   
               
               
                 2232 
                 1330 
                 GAGGAGUUUAGAGUUGCAGCU 
                 2574 
                 CUGCAACUCUAAACUCCUCAU 
                 73.3 
                 51.3 
               
               
                   
               
               
                 2233 
                 1331 
                 AGGAGUUUAGAGUUGCAGCUG 
                 2575 
                 GCUGCAACUCUAAACUCCUCA 
                 66.2 
                 44.2 
               
               
                   
               
               
                 2234 
                 1332 
                 GGAGUUUAGAGUUGCAGCUGG 
                 2576 
                 AGCUGCAACUCUAAACUCCUC 
                 81.6 
                 59.6 
               
               
                   
               
               
                 2235 
                 1333 
                 GAGUUUAGAGUUGCAGCUGGG 
                 2577 
                 CAGCUGCAACUCUAAACUCCU 
                 72.1 
                 50.1 
               
               
                   
               
               
                 2260 
                 1334 
                 GGGUUUGAAGGAAGUUGGAAG 
                 2578 
                 UCCAACUUCCUUCAAACCCCU 
                 88.3 
                 55.3 
               
               
                   
               
               
                 2261 
                 1335 
                 GGUUUGAAGGAAGUUGGAAGU 
                 2579 
                 UUCCAACUUCCUUCAAACCCC 
                 83.2 
                 61.2 
               
               
                   
               
               
                 2262 
                 1335 
                 GGUUUGAAGGAAGUUGGAAGU 
                 2550 
                 CUUCCAACUUCCUUCAAACCC 
                 65.5 
                 43.5 
               
               
                   
               
               
                 2263 
                 1337 
                 UUUGAAGGAAGUUGGAAGUGG 
                 2581 
                 ACUUCCAACUUCCUUCAAACC 
                 56.7 
                 34.7 
               
               
                   
               
               
                 2264 
                 1338 
                 UUGAAGGAAGUUGGAAGUGGG 
                 2582 
                 CACUUCCAACUUCCUUCAAAC 
                 47.3 
                 25.3 
               
               
                   
               
               
                 2294 
                 1339 
                 GGGCAUCUGGUCUCAGAAAUG 
                 2583 
                 UUUCUGAGACCAGAUGCCCCC 
                 82.2 
                 60.2 
               
               
                   
               
               
                 2295 
                 1340 
                 GGCAUCUGGUCUCAGAAAUGG 
                 2584 
                 AUUUCUGAGACCAGAUGCCCC 
                 77.6 
                 55.6 
               
               
                   
               
               
                 2296 
                 1341 
                 GCAUCUGGUCUCAGAAAUGGA 
                 2585 
                 CAUUUCUGAGACCAGAUGCCC 
                 69.2 
                 47.2 
               
               
                   
               
               
                 2297 
                 1342 
                 CAUCUGGUCUCAGAAAUGGAC 
                 2586 
                 CCAUUUCUGAGACCAGAUGCC 
                 58.3 
                 36.3 
               
               
                   
               
               
                 2298 
                 1343 
                 AUCUGGUCUCAGAAAUGGACC 
                 2587 
                 UCCAUUUCUGAGACCAGAUGC 
                 74.3 
                 52.3 
               
               
                   
               
               
                 2299 
                 1344 
                 UCUGGUCUCAGAAAUGGACCA 
                 2588 
                 GUCCAUUUCUGAGACCAGAUG 
                 65.3 
                 43.3 
               
               
                   
               
               
                 2300 
                 1345 
                 CUGGUCUCAGAAAUGGACCAG 
                 2589 
                 GGUCCAUUUCUGAGACCAGAU 
                 56.3 
                 33.3 
               
               
                   
               
               
                 2301 
                 1346 
                 UGGUCUCAGAAAUGGACCAGC 
                 2590 
                 UGGUCCAUUUCUGAGACCAGA 
                 79.3 
                 56.3 
               
               
                   
               
               
                 2302 
                 1347 
                 GGUCUCAGAAAUGGACCAGCU 
                 2591 
                 CUGGUCCAUUUCUGAGACCAG 
                 71.2 
                 48.2 
               
               
                   
               
               
                 2303 
                 1348 
                 GUCUCAGAAAUGGACCAGCUG 
                 2592 
                 GCUGGUCCAUUUCUGAGACCA 
                 58 
                 35 
               
               
                   
               
               
                 2304 
                 1349 
                 UCUCAGAAAUGGACCAGCUGG 
                 2593 
                 AGCUGGUCCAUUUCUGAGACC 
                 62.6 
                 39.6 
               
               
                   
               
               
                 2305 
                 1350 
                 CUCAGAAAUGGACCAGCUGGA 
                 2594 
                 CAGCUGGUCCAUUUCUGAGAC 
                 63.7 
                 40.7 
               
               
                   
               
               
                 2306 
                 1351 
                 UCAGAAAUGGACCAGCUGGAU 
                 2595 
                 CCAGCUGGUCCAUUUCUGAGA 
                 59.7 
                 36.7 
               
               
                   
               
               
                 2307 
                 1352 
                 CAGAAAUGGACCAGCUGGAUG 
                 2596 
                 UCCAGCUGGUCCAUUUCUGAG 
                 84 
                 61 
               
               
                   
               
               
                 2308 
                 1353 
                 AGAAAUGGACCAGCUGGAUGC 
                 2597 
                 AUCCAGCUGGUCCAUUUCUGA 
                 77.5 
                 54.5 
               
               
                   
               
               
                 2309 
                 1354 
                 GAAAUGGACCAGCUGGAUGCA 
                 2598 
                 CAUCCAGCUGGUCCAUUUCUG 
                 72.6 
                 49.6 
               
               
                   
               
               
                 2310 
                 1355 
                 AAAUGGACCAGCUGGAUGCAG 
                 2599 
                 GCAUCCAGCUGGUCCAUUUCU 
                 58 
                 35 
               
               
                   
               
               
                 2311 
                 1356 
                 AAUGGACCAGCUGGAUGCAGG 
                 2600 
                 UGCAUCCAGCUGGUCCAUUUC 
                 69.3 
                 46.3 
               
               
                   
               
               
                 2312 
                 1357 
                 AUGGACCAGCUGGAUGCAGGG 
                 2601 
                 CUGCAUCCAGCUGGUCCAUUU 
                 57.4 
                 34.4 
               
               
                   
               
               
                 2313 
                 1358 
                 UGGACCAGCUGGAUGCAGGGC 
                 2602 
                 CCUGCAUCCAGCUGGUCCAUU 
                 57.9 
                 34.9 
               
               
                   
               
               
                 2314 
                 1359 
                 GGACCAGCUGGAUGCAGGGCA 
                 2603 
                 CCCUGCAUCCAGCUGGUCCAU 
                 67.8 
                 44.8 
               
               
                   
               
               
                 2315 
                 1360 
                 GACCAGCUGGAUGCAGGGCAG 
                 2604 
                 GCCCUGCAUCCAGCUGGUCCA 
                 51.3 
                 28.3 
               
               
                   
               
               
                 2316 
                 1361 
                 ACCAGCUGGAUGCAGGGCAGG 
                 2605 
                 UGCCCUGCAUCCAGCUGGUCC 
                 59.1 
                 36.1 
               
               
                   
               
               
                 2317 
                 1362 
                 CCAGCUGGAUGCAGGGCAGGG 
                 2606 
                 CUGCCCUGCAUCCAGCUGGUC 
                 66.2 
                 43.2 
               
               
                   
               
               
                 2336 
                 1363 
                 GGGACUGAGGGUGCUUGAGUA 
                 2607 
                 CUCAAGCACCCUCAGUCCCCU 
                 64.8 
                 41.8 
               
               
                   
               
               
                 2337 
                 1364 
                 GGACUGAGGGUGCUUGAGUAG 
                 2608 
                 ACUCAAGCACCCUCAGUCCCC 
                 67.6 
                 44.6 
               
               
                   
               
               
                 2338 
                 1365 
                 GACUGAGGGUGCUUGAGUAGG 
                 2609 
                 UACUCAAGCACCCUCAGUCCC 
                 81.7 
                 58.7 
               
               
                   
               
               
                 2339 
                 1366 
                 ACUGAGGGUGCUUGAGUAGGA 
                 2610 
                 CUACUCAAGCACCCUCAGUCC 
                 57.9 
                 34.9 
               
               
                   
               
               
                 2340 
                 1367 
                 CUGAGGGUGCUUGAGUAGGAU 
                 2611 
                 CCUACUCAAGCACCCUCAGUC 
                 52.4 
                 29.4 
               
               
                   
               
               
                 2341 
                 1365 
                 UGAGGGUGCUUGAGUAGGAUG 
                 2612 
                 UCCUACUCAAGCACCCUCAGU 
                 76.8 
                 53.8 
               
               
                   
               
               
                 2342 
                 1369 
                 GAGGGUGCUUGAGUAGGAUGU 
                 2613 
                 AUCCUACUCAAGCACCCUCAG 
                 80.6 
                 57.6 
               
               
                   
               
               
                 2343 
                 1370 
                 AGGGUGCUUGAGUAGGAUGUG 
                 2614 
                 CAUCCUACUCAAGCACCCUCA 
                 67.1 
                 44.1 
               
               
                   
               
               
                 2344 
                 1371 
                 GGGUGCUUGAGUAGGAUGUGA 
                 2615 
                 ACAUCCUACUCAAGCACCCUC 
                 76.7 
                 53.7 
               
               
                   
               
               
                 2345 
                 1372 
                 GGUGCUUGAGUAGGAUGUGAG 
                 2616 
                 CACAUCCUACUCAAGCACCCU 
                 75.4 
                 52.4 
               
               
                   
               
               
                 2346 
                 1373 
                 GUGCUUGAGUAGGAUGUGAGA 
                 2617 
                 UCACAUCCUACUCAAGCACCC 
                 77.5 
                 54.5 
               
               
                   
               
               
                 2347 
                 1374 
                 UGCUUGAGUAGGAUGUGAGAC 
                 2618 
                 CUCACAUCCUACUCAAGCACC 
                 57.7 
                 34.7 
               
               
                   
               
               
                 2348 
                 1375 
                 GCUUGAGUAGGAUGUGAGACU 
                 2619 
                 UCUCACAUCCUACUCAAGCAC 
                 86.9 
                 63.9 
               
               
                   
               
               
                 2349 
                 1376 
                 CUUGAGUAGGAUGUGAGACUU 
                 2620 
                 GUCUCACAUCCUACUCAAGCA 
                 62.2 
                 39.2 
               
               
                   
               
               
                 2350 
                 1377 
                 UUGAGUAGGAUGUGAGACUUC 
                 2621 
                 AGUCUCACAUCCUACUCAAGC 
                 60.7 
                 37.7 
               
               
                   
               
               
                 2351 
                 1378 
                 UGAGUAGGAUGUGAGACUUCA 
                 2622 
                 AAGUCUCACAUCCUACUCAAG 
                 80.4 
                 57.4 
               
               
                   
               
               
                 2352 
                 1379 
                 GAGUAGGAUGUGAGACUUCAU 
                 2623 
                 GAAGUCUCACAUCCUACUCAA 
                 76.7 
                 53.7 
               
               
                   
               
               
                 2353 
                 1380 
                 AGUAGGAUGUGAGACUUCAUG 
                 2624 
                 UGAAGUCUCACAUCCUACUCA 
                 88.9 
                 65.9 
               
               
                   
               
               
                 2354 
                 1381 
                 GUAGGAUGUGAGACUUCAUGG 
                 2625 
                 AUGAAGUCUCACAUCCUACUC 
                 85.4 
                 62.4 
               
               
                   
               
               
                 2355 
                 1382 
                 UAGGAUGUGAGACUUCAUGGG 
                 2626 
                 CAUGAAGUCUCACAUCCUACU 
                 62.3 
                 39.3 
               
               
                   
               
               
                 2356 
                 1383 
                 AGGAUGUGAGACUUCAUGGGC 
                 2627 
                 CCAUGAAGUCUCACAUCCUAC 
                 61.7 
                 38.7 
               
               
                   
               
               
                 2357 
                 1384 
                 GGAUGUGAGACUUCAUGGGCC 
                 2628 
                 CCCAUGAAGUCUCACAUCCUA 
                 74.5 
                 51.5 
               
               
                   
               
               
                 2358 
                 1385 
                 GAUGUGAGACUUCAUGGGCCU 
                 2629 
                 GCCCAUGAAGUCUCACAUCCU 
                 60.9 
                 37.9 
               
               
                   
               
               
                 2359 
                 1386 
                 AUGUGAGACUUCAUGGGCCUG 
                 2630 
                 GGCCCAUGAAGUCUCACAUCC 
                 42.4 
                 19.4 
               
               
                   
               
               
                 2360 
                 1387 
                 UGUGAGACUUCAUGGGCCUGG 
                 2631 
                 AGGCCCAUGAAGUCUCACAUC 
                 62.7 
                 39.7 
               
               
                   
               
               
                 2361 
                 1388 
                 GUGAGACUUCAUGGGCCUGGG 
                 2632 
                 CAGGCCCAUGAAGUCUCACAU 
                 59.6 
                 36.6 
               
               
                   
               
               
                 2362 
                 1389 
                 UGAGACUUCAUGGGCCUGGGU 
                 2633 
                 CCAGGCCCAUGAAGUCUCACA 
                 42.4 
                 19.4 
               
               
                   
               
               
                 2363 
                 1390 
                 GAGACUUCAUGGGCCUGGGUU 
                 2634 
                 CCCAGGCCCAUGAAGUCUCAC 
                 51.5 
                 28.5 
               
               
                   
               
               
                 2364 
                 1391 
                 AGACUUCAUGGGCCUGGGUUC 
                 2635 
                 ACCCAGGCCCAUGAAGUCUCA 
                 61.3 
                 38.3 
               
               
                   
               
               
                 2365 
                 1392 
                 GACUUCAUGGGCCUGGGUUCU 
                 2636 
                 AACCCAGGCCCAUGAAGUCUC 
                 61.7 
                 38.7 
               
               
                   
               
               
                 2366 
                 1393 
                 ACUUCAUGGGCCUGGGUUCUG 
                 2637 
                 GAACCCAGGCCCAUGAAGUCU 
                 56.1 
                 33.1 
               
               
                   
               
               
                 2367 
                 1394 
                 CUUCAUGGGCCUGGGUUCUGU 
                 2638 
                 AGAACCCAGGCCCAUGAAGUC 
                 56.2 
                 33.2 
               
               
                   
               
               
                 2368 
                 1395 
                 UUCAUGGGCCUGGGUUCUGUU 
                 2639 
                 CAGAACCCAGGCCCAUGAAGU 
                 43.1 
                 20.1 
               
               
                   
               
               
                 2369 
                 1396 
                 UCAUGGGCCUGGGUUCUGUUG 
                 2640 
                 ACAGAACCCAGGCCCAUGAAG 
                 59 
                 36 
               
               
                   
               
               
                 2370 
                 1397 
                 CAUGGGCCUGGGUUCUGUUGA 
                 2641 
                 AACAGAACCCAGGCCCAUGAA 
                 73.3 
                 50.3 
               
               
                   
               
               
                 2371 
                 1398 
                 AUGGGCCUGGGUUCUGUUGAG 
                 2642 
                 CAACAGAACCCAGGCCCAUGA 
                 54.5 
                 31.5 
               
               
                   
               
               
                 2372 
                 1399 
                 UGGGCCUGGGUUCUGUUGAGU 
                 2643 
                 UCAACAGAACCCAGGCCCAUG 
                 69.3 
                 46.3 
               
               
                   
               
               
                 2373 
                 1400 
                 GGGCCUGGGUUCUGUUGAGUU 
                 2644 
                 CUCAACAGAACCCAGGCCCAU 
                 72.9 
                 49.9 
               
               
                   
               
               
                 2374 
                 1401 
                 GGCCUGGGUUCUGUUGAGUUU 
                 2645 
                 ACUCAACAGAACCCAGGCCCA 
                 71.9 
                 48.9 
               
               
                   
               
               
                 2395 
                 1402 
                 UUUCAGUAUCAAUUUCUUAAA 
                 2646 
                 UAAGAAAUUGAUACUGAAAAA 
                 78.6 
                 55.6 
               
               
                   
               
               
                 2396 
                 1403 
                 UUCAGUAUCAAUUUCUUAAAC 
                 2647 
                 UUAAGAAAUUGAUACUGAAAA 
                 78.3 
                 55.3 
               
               
                   
               
               
                 2397 
                 1404 
                 UCAGUAUCAAUUUCUUAAACC 
                 2648 
                 UUUAAGAAAUUGAUACUGAAA 
                 83.6 
                 60.6 
               
               
                   
               
               
                 2398 
                 1405 
                 CAGUAUCAAUUUCUUAAACCA 
                 2649 
                 GUUUAAGAAAUUGAUACUGAA 
                 72.1 
                 49.1 
               
               
                   
               
               
                 2399 
                 1406 
                 AGUAUCAAUUUCUUAAACCAA 
                 2650 
                 GGUUUAAGAAAUUGAUACUGA 
                 59.3 
                 36.3 
               
               
                   
               
               
                 2400 
                 1407 
                 GUAUCAAUUUCUUAAACCAAA 
                 2651 
                 UGGUUUAAGAAAUUGAUACUG 
                 88.9 
                 64.9 
               
               
                   
               
               
                 2401 
                 1408 
                 UAUCAAUUUCUUAAACCAAAU 
                 2652 
                 UUGGUUUAAGAAAUUGAUACU 
                 79.7 
                 55.7 
               
               
                   
               
               
                 2402 
                 1409 
                 AUCAAUUUCUUAAACCAAAUU 
                 2653 
                 UUUGGUUUAAGAAAUUGAUAC 
                 77.6 
                 53.6 
               
               
                   
               
               
                 2403 
                 1410 
                 UCAAUUUCUUAAACCAAAUUU 
                 2654 
                 AUUUGGUUUAAGAAAUUGAUA 
                 78 
                 54 
               
               
                   
               
               
                 2443 
                 1411 
                 GGGUGCUCAUCUCGUGACCUC 
                 2655 
                 GGUCACGAGAUGAGCACCCCC 
                 57.6 
                 33.6 
               
               
                   
               
               
                 2444 
                 1412 
                 GGUGCUCAUCUCGUGACCUCU 
                 2656 
                 AGGUCACGAGAUGAGCACCCC 
                 66 
                 42 
               
               
                   
               
               
                 2445 
                 1413 
                 GUGCUCAUCUCGUGACCUCUG 
                 2657 
                 GAGGUCACGAGAUGAGCACCC 
                 57.1 
                 33.1 
               
               
                   
               
               
                 2446 
                 1414 
                 UGCUCAUCUCGUGACCUCUGC 
                 2658 
                 AGAGGUCACGAGAUGAGCACC 
                 59.8 
                 35.8 
               
               
                   
               
               
                 2447 
                 1415 
                 GCUCAUCUCGUGACCUCUGCC 
                 2659 
                 CAGAGGUCACGAGAUGAGCAC 
                 65.9 
                 41.9 
               
               
                   
               
               
                 2448 
                 1416 
                 CUCAUCUCGUGACCUCUGCCA 
                 2660 
                 GCAGAGGUCACGAGAUGAGCA 
                 54.4 
                 30.4 
               
               
                   
               
               
                 2449 
                 1417 
                 UCAUCUCGUGACCUCUGCCAC 
                 2661 
                 GGCAGAGGUCACGAGAUGAGC 
                 42 
                 18 
               
               
                   
               
               
                 2468 
                 1418 
                 ACCCACAUCCUUCACAAACUC 
                 2662 
                 GUUUGUGAAGGAUGUGGGUGG 
                 62.2 
                 38.2 
               
               
                   
               
               
                 2469 
                 1419 
                 CCCACAUCCUUCACAAACUCC 
                 2663 
                 AGUUUGUGAAGGAUGUGGGUG 
                 79.7 
                 55.7 
               
               
                   
               
               
                 2470 
                 1420 
                 CCACAUCCUUCACAAACUCCA 
                 2664 
                 GAGUUUGUGAAGGAUGUGGGU 
                 74.1 
                 50.1 
               
               
                   
               
               
                 2471 
                 1421 
                 CACAUCCUUCACAAACUCCAU 
                 2665 
                 GGAGUUUGUGAAGGAUGUGGG 
                 62 
                 38 
               
               
                   
               
               
                 2472 
                 1422 
                 ACAUCCUUCACAAACUCCAUG 
                 2666 
                 UGGAGUUUGUGAAGGAUGUGG 
                 80.5 
                 56.5 
               
               
                   
               
               
                 2473 
                 1423 
                 CAUCCUUCACAAACUCCAUGU 
                 2667 
                 AUGGAGUUUGUGAAGGAUGUG 
                 86.6 
                 62.6 
               
               
                   
               
               
                 2474 
                 1424 
                 AUCCUUCACAAACUCCAUGUU 
                 2668 
                 CAUGGAGUUUGUGAAGGAUGU 
                 58.6 
                 34.6 
               
               
                   
               
               
                 2475 
                 1425 
                 UCCUUCACAAACUCCAUGUUU 
                 2669 
                 ACAUGGAGUUUGUGAAGGAUG 
                 66.5 
                 42.5 
               
               
                   
               
               
                 2476 
                 1426 
                 CCUUCACAAACUCCAUGUUUC 
                 2670 
                 AACAUGGAGUUUGUGAAGGAU 
                 84.7 
                 60.7 
               
               
                   
               
               
                 2477 
                 1427 
                 CUUCACAAACUCCAUGUUUCA 
                 2671 
                 AAACAUGGAGUUUGUGAAGGA 
                 79.4 
                 55.4 
               
               
                   
               
               
                 2478 
                 1428 
                 UUCACAAACUCCAUGUUUCAG 
                 2672 
                 GAAACAUGGAGUUUGUGAAGG 
                 62.9 
                 38.9 
               
               
                   
               
               
                 2479 
                 1429 
                 UCACAAACUCCAUGUUUCAGU 
                 2673 
                 UGAAACAUGGAGUUUGUGAAG 
                 82.2 
                 58.2 
               
               
                   
               
               
                 2480 
                 1430 
                 CACAAACUCCAUGUUUCAGUG 
                 2674 
                 CUGAAACAUGGAGUUUGUGAA 
                 69.2 
                 45.2 
               
               
                   
               
               
                 2481 
                 1431 
                 ACAAACUCCAUGUUUCAGUGU 
                 2675 
                 ACUGAAACAUGGAGUUUGUGA 
                 69.6 
                 45.6 
               
               
                   
               
               
                 2482 
                 1432 
                 CAAACUCCAUGUUUCAGUGUU 
                 2676 
                 CACUGAAACAUGGAGUUUGUG 
                 76.8 
                 52.8 
               
               
                   
               
               
                 2483 
                 1433 
                 AAACUCCAUGUUUCAGUGUUU 
                 2677 
                 ACACUGAAACAUGGAGUUUGU 
                 70 
                 46 
               
               
                   
               
               
                 2484 
                 1434 
                 AACUCCAUGUUUCAGUGUUUG 
                 2678 
                 AACACUGAAACAUGGAGUUUG 
                 83.6 
                 59.6 
               
               
                   
               
               
                 2485 
                 1435 
                 ACUCCAUGUUUCAGUGUUUGA 
                 2679 
                 AAACACUGAAACAUGGAGUUU 
                 89.1 
                 65.1 
               
               
                   
               
               
                 2486 
                 1436 
                 CUCCAUGUUUCAGUGUUUGAG 
                 2680 
                 CAAACACUGAAACAUGGAGUU 
                 73.6 
                 49.6 
               
               
                   
               
               
                 2487 
                 1437 
                 UCCAUGUUUCAGUGUUUGAGU 
                 2681 
                 UCAAACACUGAAACAUGGAGU 
                 82.9 
                 58.9 
               
               
                   
               
               
                 2488 
                 1438 
                 CCAUGUUUCAGUGUUUGAGUC 
                 2682 
                 CUCAAACACUGAAACAUGGAG 
                 75.3 
                 51.3 
               
               
                   
               
               
                 2489 
                 1439 
                 CAUGUUUCAGUGUUUGAGUCC 
                 2683 
                 ACUCAAACACUGAAACAUGGA 
                 81.8 
                 57.8 
               
               
                   
               
               
                 2490 
                 1440 
                 AUGUUUCAGUGUUUGAGUCCA 
                 2684 
                 GACUCAAACACUGAAACAUGG 
                 70 
                 46 
               
               
                   
               
               
                 2491 
                 1441 
                 UGUUUCAGUGUUUGAGUCCAU 
                 2685 
                 GGACUCAAACACUGAAACAUG 
                 62.2 
                 38.2 
               
               
                   
               
               
                 2492 
                 1442 
                 GUUUCAGUGUUUGAGUCCAUG 
                 2686 
                 UGGACUCAAACACUGAAACAU 
                 86.5 
                 62.5 
               
               
                   
               
               
                 2493 
                 1443 
                 UUUCAGUGUUUGAGUCCAUGU 
                 2687 
                 AUGGACUCAAACACUGAAACA 
                 72.2 
                 48.2 
               
               
                   
               
               
                 2494 
                 1444 
                 UUCAGUGUUUGAGUCCAUGUU 
                 2688 
                 CAUGGACUCAAACACUGAAAC 
                 52.2 
                 28.2 
               
               
                   
               
               
                 2495 
                 1445 
                 UCAGUGUUUGAGUCCAUGUUU 
                 2689 
                 ACAUGGACUCAAACACUGAAA 
                 73.1 
                 49.1 
               
               
                   
               
               
                 2496 
                 1446 
                 CAGUGUUUGAGUCCAUGUUUA 
                 2690 
                 AACAUGGACUCAAACACUGAA 
                 89.3 
                 65.3 
               
               
                   
               
               
                 2497 
                 1447 
                 AGUGUUUGAGUCCAUGUUUAU 
                 2691 
                 AAACAUGGACUCAAACACUGA 
                 87.4 
                 63.4 
               
               
                   
               
               
                 2498 
                 1448 
                 GUGUUUGAGUCCAUGUUUAUU 
                 2692 
                 UAAACAUGGACUCAAACACUG 
                 97.8 
                 73.8 
               
               
                   
               
               
                 2499 
                 1449 
                 UGUUUGAGUCCAUGUUUAUUC 
                 2693 
                 AUAAACAUGGACUCAAACACU 
                 82.2 
                 58.2 
               
               
                   
               
               
                 2500 
                 1450 
                 GUUUGAGUCCAUGUUUAUUCU 
                 2694 
                 AAUAAACAUGGACUCAAACAC 
                 75.1 
                 50.1 
               
               
                   
               
               
                 2501 
                 1451 
                 UUUGAGUCCAUGUUUAUUCUG 
                 2695 
                 GAAUAAACAUGGACUCAAACA 
                 53.2 
                 28.2 
               
               
                   
               
               
                 2502 
                 1452 
                 UUGAGUCCAUGUUUAUUCUGC 
                 2696 
                 AGAAUAAACAUGGACUCAAAC 
                 61.9 
                 36.9 
               
               
                   
               
               
                 2503 
                 1453 
                 UGAGUCCAUGUUUAUUCUGCA 
                 2697 
                 CAGAAUAAACAUGGACUCAAA 
                 63.3 
                 38.3 
               
               
                   
               
               
                 2504 
                 1454 
                 GAGUCCAUGUUUAUUCUGCAA 
                 2698 
                 GCAGAAUAAACAUGGACUCAA 
                 66 
                 41 
               
               
                   
               
               
                 2505 
                 1455 
                 AGUCCAUGUUUAUUCUGCAAA 
                 2699 
                 UGCAGAAUAAACAUGGACUCA 
                 84.9 
                 59.9 
               
               
                   
               
               
                 2506 
                 1456 
                 GUCCAUGUUUAUUCUGCAAAU 
                 2700 
                 UUGCAGAAUAAACAUGGACUC 
                 88.8 
                 63.8 
               
               
                   
               
               
                 2507 
                 1457 
                 UCCAUGUUUAUUCUGCAAAUA 
                 2701 
                 UUUGCAGAAUAAACAUGGACU 
                 75.8 
                 50.8 
               
               
                   
               
               
                 2508 
                 1458 
                 CCAUGUUUAUUCUGCAAAUAA 
                 2702 
                 AUUUGCAGAAUAAACAUGGAC 
                 85.3 
                 60.3 
               
               
                   
               
               
                 2509 
                 1459 
                 CAUGUUUAUUCUGCAAAUAAA 
                 2703 
                 UAUUUGCAGAAUAAACAUGGA 
                 93.1 
                 68.1 
               
               
                   
               
               
                 2510 
                 1460 
                 AUGUUUAUUCUGCAAAUAAAU 
                 2704 
                 UUAUUUGCAGAAUAAACAUGG 
                 89.9 
                 64.9 
               
               
                   
               
               
                 2511 
                 1461 
                 UGUUUAUUCUGCAAAUAAAUG 
                 2705 
                 UUUAUUUGCAGAAUAAACAUG 
                 97 
                 72 
               
               
                   
               
               
                 2512 
                 1462 
                 GUUUAUUCUGCAAAUAAAUGG 
                 2706 
                 AUUUAUUUGCAGAAUAAACAU 
                 86.3 
                 61.3 
               
               
                   
               
               
                 2513 
                 1463 
                 UUUAUUCUGCAAAUAAAUGGU 
                 2707 
                 CAUUUAUUUGCAGAAUAAACA 
                 54.4 
                 29.4 
               
               
                   
               
               
                 2514 
                 1464 
                 UUAUUCUGCAAAUAAAUGGUA 
                 2708 
                 CCAUUUAUUUGCAGAAUAAAC 
                 45.6 
                 20.6 
               
               
                   
               
               
                 2515 
                 1465 
                 UAUUCUGCAAAUAAAUGGUAA 
                 2709 
                 ACCAUUUAUUUGCAGAAUAAA 
                 67.8 
                 42.8 
               
               
                   
               
               
                 2516 
                 1466 
                 AUUCUGCAAAUAAAUGGUAAU 
                 2710 
                 UACCAUUUAUUUGCAGAAUAA 
                 77.9 
                 52.9 
               
               
                   
               
               
                 2517 
                 1467 
                 UUCUGCAAAUAAAUGGUAAUG 
                 2711 
                 UUACCAUUUAUUUGCAGAAUA 
                 77.6 
                 52.6 
               
               
                   
               
               
                 2518 
                 1468 
                 UCUGCAAAUAAAUGGUAAUGU 
                 2712 
                 AUUACCAUUUAUUUGCAGAAU 
                 76.4 
                 51.4 
               
               
                   
               
               
                 2519 
                 1469 
                 CUGCAAAUAAAUGGUAAUGUA 
                 2713 
                 CAUUACCAUUUAUUUGCAGAA 
                 65.2 
                 40.2 
               
               
                   
               
               
                 2520 
                 1470 
                 UGCAAAUAAAUGGUAAUGUAU 
                 2714 
                 ACAUUACCAUUUAUUUGCAGA 
                 67.1 
                 42.1 
               
               
                   
               
               
                 2521 
                 1471 
                 GCAAAUAAAUGGUAAUGUAUU 
                 2715 
                 UACAUUACCAUUUAUUUGCAG 
                 100.6 
                 75.6 
               
               
                   
               
               
                 2522 
                 1472 
                 CAAAUAAAUGGUAAUGUAUUG 
                 2716 
                 AUACAUUACCAUUUAUUUGCA 
                 84.8 
                 59.8 
               
               
                   
               
               
                 2523 
                 1473 
                 AAAUAAAUGGUAAUGUAUUGG 
                 2717 
                 AAUACAUUACCAUUUAUUUGC 
                 73.1 
                 48.1 
               
               
                   
               
               
                 2524 
                 1474 
                 AAUAAAUGGUAAUGUAUUGGA 
                 2718 
                 CAAUACAUUACCAUUUAUUUG 
                 75.5 
                 50.5 
               
               
                   
               
               
                 2525 
                 1475 
                 AUAAAUGGUAAUGUAUUGGA 
                 2719 
                 CCAAUACAUUACCAUUUAUUU 
                 54.7 
                 29.7 
               
               
                   
               
               
                 2526 
                 1476 
                 UAAAUGGUAAUGUAUUGGA 
                 2720 
                 UCCAAUACAUUACCAUUUAUU 
                 73.6 
                 48.6 
               
               
                   
               
            
           
         
       
     
     In Table 4, “Pos.” refers to the position of the siRNA in the GPC2 input sequence. In this case, position 3 of SEQ ID NO: 1 corresponds to position 1 of siRNA positions listed in Table 4. “Score” refers to the predicted efficacy calculated from the SDIR 21 bp model, and “Corr. Score”, or Corrected Score refers to the previous efficacy score minored by the penalties from some intrinsic target features that can influence siRNA efficacy. Each row in Table 4 includes a sense region and complementary antisense region of a duplex of a representative siRNA of the disclosure. 
     In some embodiments, the sense region comprises a sequence selected from the group listed in Table 4. In some embodiments, the anti-sense region comprises a sequence selected from the group listed in Table 4. In some embodiments, the sense and anti-sense regions comprise complementary sequences selected from the group listed in Table 4. 
     In some embodiments, the siRNA comprises an RNA duplex that is 19 nucleotides in length. In some embodiments, the RNA duplex comprises a sense region and an antisense region that are selected from the group of sequences in Table 5. 
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 siRNA sense regions and anti-sense regions, 19 bp in length 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 SEQ 
                   
                 SEQ 
                   
                   
                   
               
               
                   
                 ID 
                   
                 ID 
                   
                   
                 Corr. 
               
               
                 Pos. 
                 NO: 
                 Sense Region 
                 NO: 
                 Antisense Region 
                 Score 
                 Score 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 1 
                 2721 
                 GCUCCCAUUGUCUCGGCAG 
                 4057 
                 CUGCCGAGACAAUGGGAGC 
                 66.7 
                 66.7 
               
               
                   
               
               
                 2 
                 2722 
                 CUCCCAUUGUCUCGGCAGA 
                 4058 
                 UCUGCCGAGACAAUGGGAG 
                 77.3 
                 77.3 
               
               
                   
               
               
                 3 
                 2723 
                 UCCCAUUGUCUCGGCAGAU 
                 4059 
                 AUCUGCCGAGACAAUGGGA 
                 65 
                 65 
               
               
                   
               
               
                 4 
                 2724 
                 CCCAUUGUCUCGGCAGAUG 
                 4060 
                 CAUCUGCCGAGACAAUGGG 
                 66.2 
                 66.2 
               
               
                   
               
               
                 5 
                 2725 
                 CCAUUGUCUCGGCAGAUGC 
                 4061 
                 GCAUCUGCCGAGACAAUGG 
                 65.2 
                 65.2 
               
               
                   
               
               
                 6 
                 2726 
                 CAUUGUCUCGGCAGAUGCC 
                 4062 
                 GGCAUCUGCCGAGACAAUG 
                 61.9 
                 61.9 
               
               
                   
               
               
                 7 
                 2727 
                 AUUGUCUCGGCAGAUGCCG 
                 4063 
                 CGGCAUCUGCCGAGACAAU 
                 46.6 
                 46.6 
               
               
                   
               
               
                 8 
                 2728 
                 UUGUCUCGGCAGAUGCCGC 
                 4064 
                 GCGGCAUCUGCCGAGACAA 
                 43.7 
                 43.7 
               
               
                   
               
               
                 9 
                 2729 
                 UGUCUCGGCAGAUGCCGCC 
                 4065 
                 GGCGGCAUCUGCCGAGACA 
                 42.8 
                 42.8 
               
               
                   
               
               
                 10 
                 2730 
                 GUCUCGGCAGAUGCCGCCU 
                 4066 
                 AGGCGGCAUCUGCCGAGAC 
                 61.5 
                 61.5 
               
               
                   
               
               
                 11 
                 2731 
                 UCUCGGCAGAUGCCGCCUG 
                 4067 
                 CAGGCGGCAUCUGCCGAGA 
                 49.7 
                 49.7 
               
               
                   
               
               
                 12 
                 2732 
                 CUCGGCAGAUGCCGCCUGG 
                 4068 
                 CCAGGCGGCAUCUGCCGAG 
                 52.4 
                 52.4 
               
               
                   
               
               
                 13 
                 2733 
                 UCGGCAGAUGCCGCCUGGU 
                 4069 
                 ACCAGGCGGCAUCUGCCGA 
                 51 
                 51 
               
               
                   
               
               
                 14 
                 2734 
                 CGGCAGAUGCCGCCUGGUC 
                 4070 
                 GACCAGGCGGCAUCUGCCG 
                 60.6 
                 60.6 
               
               
                   
               
               
                 15 
                 2735 
                 GGCAGAUGCCGCCUGGUCC 
                 4071 
                 GGACCAGGCGGCAUCUGCC 
                 60 
                 60 
               
               
                   
               
               
                 16 
                 2736 
                 GCAGAUGCCGCCUGGUCCA 
                 4072 
                 UGGACCAGGCGGCAUCUGC 
                 79.3 
                 79.3 
               
               
                   
               
               
                 17 
                 2737 
                 CAGAUGCCGCCUGGUCCAG 
                 4073 
                 CUGGACCAGGCGGCAUCUG 
                 58.4 
                 58.4 
               
               
                   
               
               
                 18 
                 2738 
                 AGAUGCCGCCUGGUCCAGC 
                 4074 
                 GCUGGACCAGGCGGCAUCU 
                 45 
                 45 
               
               
                   
               
               
                 19 
                 2739 
                 GAUGCCGCCUGGUCCAGCU 
                 4075 
                 AGCUGGACCAGGCGGCAUC 
                 66.8 
                 66.8 
               
               
                   
               
               
                 20 
                 2740 
                 AUGCCGCCUGGUCCAGCUA 
                 4076 
                 UAGCUGGACCAGGCGGCAU 
                 70.7 
                 70.7 
               
               
                   
               
               
                 21 
                 2741 
                 UGCCGCCUGGUCCAGCUAU 
                 4077 
                 AUAGCUGGACCAGGCGGCA 
                 64.7 
                 64.7 
               
               
                   
               
               
                 22 
                 2742 
                 GCCGCCUGGUCCAGCUAUC 
                 4078 
                 GAUAGCUGGACCAGGCGGC 
                 63.7 
                 63.7 
               
               
                   
               
               
                 23 
                 2743 
                 CCGCCUGGUCCAGCUAUCG 
                 4079 
                 CGAUAGCUGGACCAGGCGG 
                 57.4 
                 57.4 
               
               
                   
               
               
                 24 
                 2744 
                 CGCCUGGUCCAGCUAUCGU 
                 4080 
                 ACGAUAGCUGGACCAGGCG 
                 69.8 
                 69.8 
               
               
                   
               
               
                 25 
                 2745 
                 GCCUGGUCCAGCUAUCGUG 
                 4081 
                 CACGAUAGCUGGACCAGGC 
                 68.9 
                 68.9 
               
               
                   
               
               
                 26 
                 2746 
                 CCUGGUCCAGCUAUCGUGC 
                 4082 
                 GCACGAUAGCUGGACCAGG 
                 60.3 
                 60.3 
               
               
                   
               
               
                 27 
                 2747 
                 CUGGUCCAGCUAUCGUGCU 
                 4083 
                 AGCACGAUAGCUGGACCAG 
                 65.2 
                 65.2 
               
               
                   
               
               
                 28 
                 2748 
                 UGGUCCAGCUAUCGUGCUC 
                 4084 
                 GAGCACGAUAGCUGGACCA 
                 59.9 
                 59.9 
               
               
                   
               
               
                 29 
                 2749 
                 GGUCCAGCUAUCGUGCUCG 
                 4085 
                 CGAGCACGAUAGCUGGACC 
                 63.3 
                 63.3 
               
               
                   
               
               
                 30 
                 2750 
                 GUCCAGCUAUCGUGCUCGG 
                 4086 
                 CCGAGCACGAUAGCUGGAC 
                 64.1 
                 64.1 
               
               
                   
               
               
                 31 
                 2751 
                 UCCAGCUAUCGUGCUCGGU 
                 4087 
                 ACCGAGCACGAUAGCUGGA 
                 55.9 
                 55.9 
               
               
                   
               
               
                 32 
                 2752 
                 CCAGCUAUCGUGCUCGGUA 
                 4088 
                 UACCGAGCACGAUAGCUGG 
                 82.1 
                 82.1 
               
               
                   
               
               
                 33 
                 2753 
                 CAGCUAUCGUGCUCGGUAU 
                 4089 
                 AUACCGAGCACGAUAGCUG 
                 84.6 
                 84.6 
               
               
                   
               
               
                 34 
                 2754 
                 AGCUAUCGUGCUCGGUAUU 
                 4090 
                 AAUACCGAGCACGAUAGCU 
                 77.8 
                 77.8 
               
               
                   
               
               
                 35 
                 2755 
                 GCUAUCGUGCUCGGUAUUC 
                 4091 
                 GAAUACCGAGCACGAUAGC 
                 63 
                 63 
               
               
                   
               
               
                 36 
                 2756 
                 CUAUCGUGCUCGGUAUUCA 
                 4092 
                 UGAAUACCGAGCACGAUAG 
                 78.5 
                 78.5 
               
               
                   
               
               
                 37 
                 2757 
                 UAUCGUGCUCGGUAUUCAG 
                 4093 
                 CUGAAUACCGAGCACGAUA 
                 63 
                 63 
               
               
                   
               
               
                 38 
                 2758 
                 AUCGUGCUCGGUAUUCAGU 
                 4094 
                 ACUGAAUACCGAGCACGAU 
                 61.9 
                 61.9 
               
               
                   
               
               
                 39 
                 2759 
                 UCGUGCUCGGUAUUCAGUU 
                 4095 
                 AACUGAAUACCGAGCACGA 
                 66.8 
                 66.8 
               
               
                   
               
               
                 40 
                 2760 
                 CGUGCUCGGUAUUCAGUUU 
                 4096 
                 AAACUGAAUACCGAGCACG 
                 87.3 
                 87.3 
               
               
                   
               
               
                 57 
                 2761 
                 UUUCCGGAGCAGCGCUCUU 
                 4097 
                 AAGAGCGCUGCUCCGGAAA 
                 63.6 
                 63.6 
               
               
                   
               
               
                 58 
                 2762 
                 UUCCGGAGCAGCGCUCUUU 
                 4098 
                 AAAGAGCGCUGCUCCGGAA 
                 60.2 
                 60.2 
               
               
                   
               
               
                 59 
                 2763 
                 UCCGGAGCAGCGCUCUUUC 
                 4099 
                 GAAAGAGCGCUGCUCCGGA 
                 55.6 
                 55.6 
               
               
                   
               
               
                 60 
                 2764 
                 CCGGAGCAGCGCUCUUUCU 
                 4100 
                 AGAAAGAGCGCUGCUCCGG 
                 74.7 
                 74.7 
               
               
                   
               
               
                 61 
                 2765 
                 CGGAGCAGCGCUCUUUCUC 
                 4101 
                 GAGAAAGAGCGCUGCUCCG 
                 64.3 
                 64.3 
               
               
                   
               
               
                 62 
                 2766 
                 GGAGCAGCGCUCUUUCUCU 
                 4102 
                 AGAGAAAGAGCGCUGCUCC 
                 78.6 
                 78.6 
               
               
                   
               
               
                 63 
                 2767 
                 GAGCAGCGCUCUUUCUCUG 
                 4103 
                 CAGAGAAAGAGCGCUGCUC 
                 71.7 
                 71.7 
               
               
                   
               
               
                 64 
                 2768 
                 AGCAGCGCUCUUUCUCUGG 
                 4104 
                 CCAGAGAAAGAGCGCUGCU 
                 58.5 
                 58.5 
               
               
                   
               
               
                 81 
                 2769 
                 GGCCCGCGGAGCGGUCCCG 
                 4105 
                 CGGGACCGCUCCGCGGGCC 
                 51.7 
                 51.7 
               
               
                   
               
               
                 82 
                 2770 
                 GCCCGCGGAGCGGUCCCGC 
                 4106 
                 GCGGGACCGCUCCGCGGGC 
                 43.5 
                 43.5 
               
               
                   
               
               
                 83 
                 2771 
                 CCCGCGGAGCGGUCCCGCG 
                 4107 
                 CGCGGGACCGCUCCGCGGG 
                 53.5 
                 53.5 
               
               
                   
               
               
                 84 
                 2772 
                 CCGCGGAGCGGUCCCGCGG 
                 4108 
                 CCGCGGGACCGCUCCGCGG 
                 55.6 
                 55.6 
               
               
                   
               
               
                 85 
                 2773 
                 CGCGGAGCGGUCCCGCGGC 
                 4109 
                 GCCGCGGGACCGCUCCGCG 
                 52.1 
                 52.1 
               
               
                   
               
               
                 86 
                 2774 
                 GCGGAGCGGUCCCGCGGCC 
                 4110 
                 GGCCGCGGGACCGCUCCGC 
                 53.1 
                 53.1 
               
               
                   
               
               
                 87 
                 2775 
                 CGGAGCGGUCCCGCGGCCG 
                 4111 
                 CGGCCGCGGGACCGCUCCG 
                 49.3 
                 49.3 
               
               
                   
               
               
                 88 
                 2776 
                 GGAGCGGUCCCGCGGCCGA 
                 4112 
                 UCGGCCGCGGGACCGCUCC 
                 77.5 
                 77.5 
               
               
                   
               
               
                 89 
                 2777 
                 GAGCGGUCCCGCGGCCGAG 
                 4113 
                 CUCGGCCGCGGGACCGCUC 
                 60.3 
                 60.3 
               
               
                   
               
               
                 90 
                 2778 
                 AGCGGUCCCGCGGCCGAGU 
                 4114 
                 ACUCGGCCGCGGGACCGCU 
                 59.7 
                 59.7 
               
               
                   
               
               
                 91 
                 2779 
                 GCGGUCCCGCGGCCGAGUA 
                 4115 
                 UACUCGGCCGCGGGACCGC 
                 77 
                 77 
               
               
                   
               
               
                 92 
                 2780 
                 CGGUCCCGCGGCCGAGUAC 
                 4116 
                 GUACUCGGCCGCGGGACCG 
                 62.2 
                 62.2 
               
               
                   
               
               
                 93 
                 2781 
                 GGUCCCGCGGCCGAGUACC 
                 4117 
                 GGUACUCGGCCGCGGGACC 
                 53.9 
                 53.9 
               
               
                   
               
               
                 94 
                 2782 
                 GUCCCGCGGCCGAGUACCG 
                 4118 
                 CGGUACUCGGCCGCGGGAC 
                 55.3 
                 55.3 
               
               
                   
               
               
                 95 
                 2783 
                 UCCCGCGGCCGAGUACCGG 
                 4119 
                 CCGGUACUCGGCCGCGGGA 
                 39.4 
                 39.4 
               
               
                   
               
               
                 96 
                 2784 
                 CCCGCGGCCGAGUACCGGA 
                 4120 
                 UCCGGUACUCGGCCGCGGG 
                 71.2 
                 71.2 
               
               
                   
               
               
                 97 
                 2785 
                 CCGCGGCCGAGUACCGGAU 
                 4121 
                 AUCCGGUACUCGGCCGCGG 
                 72.5 
                 72.5 
               
               
                   
               
               
                 98 
                 2786 
                 CGCGGCCGAGUACCGGAUU 
                 4122 
                 AAUCCGGUACUCGGCCGCG 
                 73.3 
                 73.3 
               
               
                   
               
               
                 99 
                 2787 
                 GCGGCCGAGUACCGGAUUC 
                 4123 
                 GAAUCCGGUACUCGGCCGC 
                 66.5 
                 66.5 
               
               
                   
               
               
                 100 
                 2788 
                 CGGCCGAGUACCGGAUUCC 
                 4124 
                 GGAAUCCGGUACUCGGCCG 
                 58.4 
                 57.4 
               
               
                   
               
               
                 101 
                 2789 
                 GGCCGAGUACCGGAUUCCC 
                 4125 
                 GGGAAUCCGGUACUCGGCC 
                 61.5 
                 60.5 
               
               
                   
               
               
                 102 
                 2790 
                 GCCGAGUACCGGAUUCCCG 
                 4126 
                 CGGGAAUCCGGUACUCGGC 
                 64.4 
                 63.4 
               
               
                   
               
               
                 103 
                 2791 
                 CCGAGUACCGGAUUCCCGA 
                 4127 
                 UCGGGAAUCCGGUACUCGG 
                 82.3 
                 81.3 
               
               
                   
               
               
                 104 
                 2792 
                 CGAGUACCGGAUUCCCGAG 
                 4128 
                 CUCGGGAAUCCGGUACUCG 
                 72.3 
                 71.3 
               
               
                   
               
               
                 105 
                 2793 
                 GAGUACCGGAUUCCCGAGU 
                 4129 
                 ACUCGGGAAUCCGGUACUC 
                 69.7 
                 68.7 
               
               
                   
               
               
                 106 
                 2794 
                 AGUACCGGAUUCCCGAGUU 
                 4130 
                 AACUCGGGAAUCCGGUACU 
                 76.4 
                 75.4 
               
               
                   
               
               
                 107 
                 2795 
                 GUACCGGAUUCCCGAGUUU 
                 4131 
                 AAACUCGGGAAUCCGGUAC 
                 82.4 
                 81.4 
               
               
                   
               
               
                 108 
                 2796 
                 UACCGGAUUCCCGAGUUUG 
                 4132 
                 CAAACUCGGGAAUCCGGUA 
                 60.4 
                 59.4 
               
               
                   
               
               
                 109 
                 2797 
                 ACCGGAUUCCCGAGUUUGG 
                 4133 
                 CCAAACUCGGGAAUCCGGU 
                 63.2 
                 62.2 
               
               
                   
               
               
                 110 
                 2798 
                 CCGGAUUCCCGAGUUUGGG 
                 4134 
                 CCCAAACUCGGGAAUCCGG 
                 57.2 
                 56.2 
               
               
                   
               
               
                 111 
                 2799 
                 CGGAUUCCCGAGUUUGGGA 
                 4135 
                 UCCCAAACUCGGGAAUCCG 
                 77.8 
                 76.8 
               
               
                   
               
               
                 112 
                 2800 
                 GGAUUCCCGAGUUUGGGAG 
                 4136 
                 CUCCCAAACUCGGGAAUCC 
                 66.1 
                 65.1 
               
               
                   
               
               
                 113 
                 2801 
                 GAUUCCCGAGUUUGGGAGG 
                 4137 
                 CCUCCCAAACUCGGGAAUC 
                 59.9 
                 58.9 
               
               
                   
               
               
                 114 
                 2802 
                 AUUCCCGAGUUUGGGAGGC 
                 4138 
                 GCCUCCCAAACUCGGGAAU 
                 39.9 
                 38.9 
               
               
                   
               
               
                 115 
                 2803 
                 UUCCCGAGUUUGGGAGGCU 
                 4139 
                 AGCCUCCCAAACUCGGGAA 
                 52.9 
                 51.9 
               
               
                   
               
               
                 116 
                 2804 
                 UCCCGAGUUUGGGAGGCUC 
                 4140 
                 GAGCCUCCCAAACUCGGGA 
                 53.8 
                 52.8 
               
               
                   
               
               
                 117 
                 2805 
                 CCCGAGUUUGGGAGGCUCU 
                 4141 
                 AGAGCCUCCCAAACUCGGG 
                 73 
                 72 
               
               
                   
               
               
                 118 
                 2806 
                 CCGAGUUUGGGAGGCUCUG 
                 4142 
                 CAGAGCCUCCCAAACUCGG 
                 65.8 
                 64.8 
               
               
                   
               
               
                 119 
                 2807 
                 CGAGUUUGGGAGGCUCUGC 
                 4143 
                 GCAGAGCCUCCCAAACUCG 
                 60 
                 59 
               
               
                   
               
               
                 120 
                 2808 
                 GAGUUUGGGAGGCUCUGCU 
                 4144 
                 AGCAGAGCCUCCCAAACUC 
                 69.7 
                 68.7 
               
               
                   
               
               
                 121 
                 2809 
                 AGUUUGGGAGGCUCUGCUU 
                 4145 
                 AAGCAGAGCCUCCCAAACU 
                 76.8 
                 75.8 
               
               
                   
               
               
                 122 
                 2810 
                 GUUUGGGAGGCUCUGCUUU 
                 4146 
                 AAAGCAGAGCCUCCCAAAC 
                 74.8 
                 73.8 
               
               
                   
               
               
                 123 
                 2811 
                 UUUGGGAGGCUCUGCUUUC 
                 4147 
                 GAAAGCAGAGCCUCCCAAA 
                 50.8 
                 49.8 
               
               
                   
               
               
                 124 
                 2812 
                 UUGGGAGGCUCUGCUUUCC 
                 4148 
                 GGAAAGCAGAGCCUCCCAA 
                 44.3 
                 43.3 
               
               
                   
               
               
                 125 
                 2813 
                 UGGGAGGCUCUGCUUUCCU 
                 4149 
                 AGGAAAGCAGAGCCUCCCA 
                 61.3 
                 60.3 
               
               
                   
               
               
                 126 
                 2814 
                 GGGAGGCUCUGCUUUCCUC 
                 4150 
                 GAGGAAAGCAGAGCCUCCC 
                 68.6 
                 67.6 
               
               
                   
               
               
                 127 
                 2815 
                 GGAGGCUCUGCUUUCCUCC 
                 4151 
                 GGAGGAAAGCAGAGCCUCC 
                 61.6 
                 60.6 
               
               
                   
               
               
                 128 
                 2816 
                 GAGGCUCUGCUUUCCUCCU 
                 4152 
                 AGGAGGAAAGCAGAGCCUC 
                 73.5 
                 72.5 
               
               
                   
               
               
                 129 
                 2817 
                 AGGCUCUGCUUUCCUCCUU 
                 4153 
                 AAGGAGGAAAGCAGAGCCU 
                 74 
                 73 
               
               
                   
               
               
                 130 
                 2818 
                 GGCUCUGCUUUCCUCCUUA 
                 4154 
                 UAAGGAGGAAAGCAGAGCC 
                 92.8 
                 91.8 
               
               
                   
               
               
                 131 
                 2819 
                 GCUCUGCUUUCCUCCUUAG 
                 4155 
                 CUAAGGAGGAAAGCAGAGC 
                 78.7 
                 77.7 
               
               
                   
               
               
                 132 
                 2820 
                 CUCUGCUUUCCUCCUUAGG 
                 4156 
                 CCUAAGGAGGAAAGCAGAG 
                 59.6 
                 58.6 
               
               
                   
               
               
                 133 
                 2821 
                 UCUGCUUUCCUCCUUAGGA 
                 4157 
                 UCCUAAGGAGGAAAGCAGA 
                 69.4 
                 68.4 
               
               
                   
               
               
                 134 
                 2822 
                 CUGCUUUCCUCCUUAGGAC 
                 4158 
                 GUCCUAAGGAGGAAAGCAG 
                 64.4 
                 63.4 
               
               
                   
               
               
                 135 
                 2823 
                 UGCUUUCCUCCUUAGGACC 
                 4159 
                 GGUCCUAAGGAGGAAAGCA 
                 55.9 
                 54.9 
               
               
                   
               
               
                 136 
                 2824 
                 GCUUUCCUCCUUAGGACCC 
                 4160 
                 GGGUCCUAAGGAGGAAAGC 
                 60 
                 59 
               
               
                   
               
               
                 137 
                 2825 
                 CUUUCCUCCUUAGGACCCA 
                 4161 
                 UGGGUCCUAAGGAGGAAAG 
                 72.1 
                 71.1 
               
               
                   
               
               
                 138 
                 2826 
                 UUUCCUCCUUAGGACCCAC 
                 4162 
                 GUGGGUCCUAAGGAGGAAA 
                 50.3 
                 49.3 
               
               
                   
               
               
                 139 
                 2827 
                 UUCCUCCUUAGGACCCACU 
                 4163 
                 AGUGGGUCCUAAGGAGGAA 
                 54 
                 53 
               
               
                   
               
               
                 140 
                 2828 
                 UCCUCCUUAGGACCCACUU 
                 4164 
                 AAGUGGGUCCUAAGGAGGA 
                 67.1 
                 66.1 
               
               
                   
               
               
                 141 
                 2829 
                 CCUCCUUAGGACCCACUUU 
                 4165 
                 AAAGUGGGUCCUAAGGAGG 
                 79.3 
                 78.3 
               
               
                   
               
               
                 142 
                 2830 
                 CUCCUUAGGACCCACUUUG 
                 4166 
                 CAAAGUGGGUCCUAAGGAG 
                 64.6 
                 63.6 
               
               
                   
               
               
                 143 
                 2831 
                 UCCUUAGGACCCACUUUGC 
                 4167 
                 GCAAAGUGGGUCCUAAGGA 
                 54.2 
                 53.2 
               
               
                   
               
               
                 144 
                 2832 
                 CCUUAGGACCCACUUUGCC 
                 4168 
                 GGCAAAGUGGGUCCUAAGG 
                 56.6 
                 55.6 
               
               
                   
               
               
                 145 
                 2833 
                 CUUAGGACCCACUUUGCCG 
                 4169 
                 CGGCAAAGUGGGUCCUAAG 
                 56.1 
                 55.1 
               
               
                   
               
               
                 146 
                 2834 
                 UUAGGACCCACUUUGCCGU 
                 4170 
                 ACGGCAAAGUGGGUCCUAA 
                 51.4 
                 50.4 
               
               
                   
               
               
                 147 
                 2835 
                 UAGGACCCACUUUGCCGUC 
                 4171 
                 GACGGCAAAGUGGGUCCUA 
                 45.6 
                 44.6 
               
               
                   
               
               
                 148 
                 2836 
                 AGGACCCACUUUGCCGUCC 
                 4172 
                 GGACGGCAAAGUGGGUCCU 
                 46.8 
                 45.8 
               
               
                   
               
               
                 149 
                 2837 
                 GGACCCACUUUGCCGUCCU 
                 4173 
                 AGGACGGCAAAGUGGGUCC 
                 71.8 
                 70.8 
               
               
                   
               
               
                 150 
                 2838 
                 GACCCACUUUGCCGUCCUG 
                 4174 
                 CAGGACGGCAAAGUGGGUC 
                 66.3 
                 65.3 
               
               
                   
               
               
                 151 
                 2839 
                 ACCCACUUUGCCGUCCUGG 
                 4175 
                 CCAGGACGGCAAAGUGGGU 
                 43.4 
                 42.4 
               
               
                   
               
               
                 152 
                 2840 
                 CCCACUUUGCCGUCCUGGG 
                 4176 
                 CCCAGGACGGCAAAGUGGG 
                 52.2 
                 51.2 
               
               
                   
               
               
                 173 
                 2841 
                 GGCUGCAGUUAUGUCCGCG 
                 4177 
                 CGCGGACAUAACUGCAGCC 
                 64.5 
                 63.5 
               
               
                   
               
               
                 174 
                 2842 
                 GCUGCAGUUAUGUCCGCGC 
                 4178 
                 GCGCGGACAUAACUGCAGC 
                 63.3 
                 62.3 
               
               
                   
               
               
                 175 
                 2843 
                 CUGCAGUUAUGUCCGCGCU 
                 4179 
                 AGCGCGGACAUAACUGCAG 
                 73.6 
                 72.6 
               
               
                   
               
               
                 176 
                 2844 
                 UGCAGUUAUGUCCGCGCUG 
                 4180 
                 CAGCGCGGACAUAACUGCA 
                 63.9 
                 62.9 
               
               
                   
               
               
                 177 
                 2845 
                 GCAGUUAUGUCCGCGCUGC 
                 4181 
                 GCAGCGCGGACAUAACUGC 
                 64.7 
                 63.7 
               
               
                   
               
               
                 178 
                 2846 
                 CAGUUAUGUCCGCGCUGCG 
                 4182 
                 CGCAGCGCGGACAUAACUG 
                 65.1 
                 64.1 
               
               
                   
               
               
                 179 
                 2847 
                 AGUUAUGUCCGCGCUGCGA 
                 4183 
                 UCGCAGCGCGGACAUAACU 
                 80.4 
                 79.4 
               
               
                   
               
               
                 180 
                 2848 
                 GUUAUGUCCGCGCUGCGAC 
                 4184 
                 GUCGCAGCGCGGACAUAAC 
                 64.7 
                 63.7 
               
               
                   
               
               
                 181 
                 2849 
                 UUAUGUCCGCGCUGCGACC 
                 4185 
                 GGUCGCAGCGCGGACAUAA 
                 50 
                 49 
               
               
                   
               
               
                 182 
                 2850 
                 UAUGUCCGCGCUGCGACCU 
                 4186 
                 AGGUCGCAGCGCGGACAUA 
                 55.1 
                 54.1 
               
               
                   
               
               
                 183 
                 2851 
                 AUGUCCGCGCUGCGACCUC 
                 4187 
                 GAGGUCGCAGCGCGGACAU 
                 53.9 
                 52.9 
               
               
                   
               
               
                 184 
                 2852 
                 UGUCCGCGCUGCGACCUCU 
                 4188 
                 AGAGGUCGCAGCGCGGACA 
                 67.7 
                 66.7 
               
               
                   
               
               
                 185 
                 2853 
                 GUCCGCGCUGCGACCUCUC 
                 4189 
                 GAGAGGUCGCAGCGCGGAC 
                 62.1 
                 61.1 
               
               
                   
               
               
                 186 
                 2854 
                 UCCGCGCUGCGACCUCUCC 
                 4190 
                 GGAGAGGUCGCAGCGCGGA 
                 50.6 
                 49.6 
               
               
                   
               
               
                 187 
                 2855 
                 CCGCGCUGCGACCUCUCCU 
                 4191 
                 AGGAGAGGUCGCAGCGCGG 
                 68.7 
                 67.7 
               
               
                   
               
               
                 188 
                 2856 
                 CGCGCUGCGACCUCUCCUG 
                 4192 
                 CAGGAGAGGUCGCAGCGCG 
                 68.7 
                 67.7 
               
               
                   
               
               
                 189 
                 2857 
                 GCGCUGCGACCUCUCCUGC 
                 4193 
                 GCAGGAGAGGUCGCAGCGC 
                 62.6 
                 61.6 
               
               
                   
               
               
                 190 
                 2858 
                 CGCUGCGACCUCUCCUGCU 
                 4194 
                 AGCAGGAGAGGUCGCAGCG 
                 74.8 
                 73.8 
               
               
                   
               
               
                 191 
                 2859 
                 GCUGCGACCUCUCCUGCUU 
                 4195 
                 AAGCAGGAGAGGUCGCAGC 
                 86.7 
                 85.7 
               
               
                   
               
               
                 192 
                 2860 
                 CUGCGACCUCUCCUGCUUC 
                 4196 
                 GAAGCAGGAGAGGUCGCAG 
                 65.2 
                 64.2 
               
               
                   
               
               
                 193 
                 2861 
                 UGCGACCUCUCCUGCUUCU 
                 4197 
                 AGAAGCAGGAGAGGUCGCA 
                 71 
                 70 
               
               
                   
               
               
                 194 
                 2862 
                 GCGACCUCUCCUGCUUCUG 
                 4198 
                 CAGAAGCAGGAGAGGUCGC 
                 68.9 
                 67.9 
               
               
                   
               
               
                 195 
                 2863 
                 CGACCUCUCCUGCUUCUGC 
                 4199 
                 GCAGAAGCAGGAGAGGUCG 
                 65.4 
                 64.4 
               
               
                   
               
               
                 196 
                 2864 
                 GACCUCUCCUGCUUCUGCU 
                 4200 
                 AGCAGAAGCAGGAGAGGUC 
                 74.3 
                 73.3 
               
               
                   
               
               
                 197 
                 2865 
                 ACCUCUCCUGCUUCUGCUG 
                 4201 
                 CAGCAGAAGCAGGAGAGGU 
                 64.2 
                 63.2 
               
               
                   
               
               
                 198 
                 2866 
                 CCUCUCCUGCUUCUGCUGC 
                 4202 
                 GCAGCAGAAGCAGGAGAGG 
                 56 
                 55 
               
               
                   
               
               
                 199 
                 2867 
                 CUCUCCUGCUUCUGCUGCU 
                 4203 
                 AGCAGCAGAAGCAGGAGAG 
                 70.4 
                 69.4 
               
               
                   
               
               
                 200 
                 2868 
                 UCUCCUGCUUCUGCUGCUG 
                 4204 
                 CAGCAGCAGAAGCAGGAGA 
                 59.6 
                 57.6 
               
               
                   
               
               
                 201 
                 2869 
                 CUCCUGCUUCUGCUGCUGC 
                 4205 
                 GCAGCAGCAGAAGCAGGAG 
                 55.8 
                 53.8 
               
               
                   
               
               
                 202 
                 2870 
                 UCCUGCUUCUGCUGCUGCC 
                 4206 
                 GGCAGCAGCAGAAGCAGGA 
                 51.3 
                 49.3 
               
               
                   
               
               
                 203 
                 2871 
                 CCUGCUUCUGCUGCUGCCU 
                 4207 
                 AGGCAGCAGCAGAAGCAGG 
                 68.8 
                 66.8 
               
               
                   
               
               
                 204 
                 2872 
                 CUGCUUCUGCUGCUGCCUC 
                 4208 
                 GAGGCAGCAGCAGAAGCAG 
                 58.8 
                 56.8 
               
               
                   
               
               
                 205 
                 2873 
                 UGCUUCUGCUGCUGCCUCU 
                 4209 
                 AGAGGCAGCAGCAGAAGCA 
                 68.6 
                 66.6 
               
               
                   
               
               
                 206 
                 2874 
                 GCUUCUGCUGCUGCCUCUG 
                 4210 
                 CAGAGGCAGCAGCAGAAGC 
                 68.9 
                 66.9 
               
               
                   
               
               
                 207 
                 2875 
                 CUUCUGCUGCUGCCUCUGU 
                 4211 
                 ACAGAGGCAGCAGCAGAAG 
                 68.9 
                 66.9 
               
               
                   
               
               
                 208 
                 2876 
                 UUCUGCUGCUGCCUCUGUG 
                 4212 
                 CACAGAGGCAGCAGCAGAA 
                 53.8 
                 51.8 
               
               
                   
               
               
                 209 
                 2877 
                 UCUGCUGCUGCCUCUGUGU 
                 4213 
                 ACACAGAGGCAGCAGCAGA 
                 65.6 
                 63.6 
               
               
                   
               
               
                 210 
                 2878 
                 CUGCUGCUGCCUCUGUGUC 
                 4214 
                 GACACAGAGGCAGCAGCAG 
                 59.7 
                 57.7 
               
               
                   
               
               
                 211 
                 2879 
                 UGCUGCUGCCUCUGUGUCC 
                 4215 
                 GGACACAGAGGCAGCAGCA 
                 54.8 
                 52.8 
               
               
                   
               
               
                 212 
                 2880 
                 GCUGCUGCCUCUGUGUCCC 
                 4216 
                 GGGACACAGAGGCAGCAGC 
                 60.7 
                 58.7 
               
               
                   
               
               
                 213 
                 2881 
                 CUGCUGCCUCUGUGUCCCG 
                 4217 
                 CGGGACACAGAGGCAGCAG 
                 57.1 
                 55.1 
               
               
                   
               
               
                 214 
                 2882 
                 UGCUGCCUCUGUGUCCCGG 
                 4218 
                 CCGGGACACAGAGGCAGCA 
                 49.3 
                 47.3 
               
               
                   
               
               
                 215 
                 2883 
                 GCUGCCUCUGUGUCCCGGU 
                 4219 
                 ACCGGGACACAGAGGCAGC 
                 65.6 
                 66.6 
               
               
                   
               
               
                 216 
                 2884 
                 CUGCCUCUGUGUCCCGGUC 
                 4220 
                 GACCGGGACACAGAGGCAG 
                 60 
                 58 
               
               
                   
               
               
                 217 
                 2885 
                 UGCCUCUGUGUCCCGGUCC 
                 4221 
                 GGACCGGGACACAGAGGCA 
                 48.2 
                 46.2 
               
               
                   
               
               
                 218 
                 2886 
                 GCCUCUGUGUCCCGGUCCU 
                 4222 
                 AGGACCGGGACACAGAGGC 
                 76.7 
                 74.7 
               
               
                   
               
               
                 219 
                 2887 
                 CCUCUGUGUCCCGGUCCUG 
                 4223 
                 CAGGACCGGGACACAGAGG 
                 64.8 
                 62.8 
               
               
                   
               
               
                 220 
                 2888 
                 CUCUGUGUCCCGGUCCUGG 
                 4224 
                 CCAGGACCGGGACACAGAG 
                 55.8 
                 53.8 
               
               
                   
               
               
                 221 
                 2889 
                 UCUGUGUCCCGGUCCUGGU 
                 4225 
                 ACCAGGACCGGGACACAGA 
                 63.4 
                 61.4 
               
               
                   
               
               
                 222 
                 2890 
                 CUGUGUCCCGGUCCUGGUC 
                 4226 
                 GACCAGGACCGGGACACAG 
                 61 
                 59 
               
               
                   
               
               
                 223 
                 2891 
                 UGUGUCCCGGUCCUGGUCC 
                 4227 
                 GGACCAGGACCGGGACACA 
                 47.5 
                 45.5 
               
               
                   
               
               
                 224 
                 2892 
                 GUGUCCCGGUCCUGGUCCC 
                 4228 
                 GGGACCAGGACCGGGACAC 
                 56 
                 54 
               
               
                   
               
               
                 225 
                 2893 
                 UGUCCCGGUCCUGGUCCCG 
                 4229 
                 CGGGACCAGGACCGGGACA 
                 46 
                 44 
               
               
                   
               
               
                 226 
                 2894 
                 GUCCCGGUCCUGGUCCCGG 
                 4230 
                 CCGGGACCAGGACCGGGAC 
                 49.5 
                 47.5 
               
               
                   
               
               
                 227 
                 2895 
                 UCCCGGUCCUGGUCCCGGA 
                 4231 
                 UCCGGGACCAGGACCGGGA 
                 67.1 
                 65.1 
               
               
                   
               
               
                 228 
                 2896 
                 CCCGGUCCUGGUCCCGGAC 
                 4232 
                 GUCCGGGACCAGGACCGGG 
                 59.4 
                 57.4 
               
               
                   
               
               
                 229 
                 2897 
                 CCGGUCCUGGUCCCGGACC 
                 4233 
                 GGUCCGGGACCAGGACCGG 
                 50.3 
                 48.3 
               
               
                   
               
               
                 230 
                 2898 
                 CGGUCCUGGUCCCGGACCC 
                 4234 
                 GGGUCCGGGACCAGGACCG 
                 58 
                 56 
               
               
                   
               
               
                 231 
                 2899 
                 GGUCCUGGUCCCGGACCCG 
                 4235 
                 CGGGUCCGGGACCAGGACC 
                 60.4 
                 58.4 
               
               
                   
               
               
                 232 
                 2900 
                 GUCCUGGUCCCGGACCCGG 
                 4236 
                 CCGGGUCCGGGACCAGGAC 
                 51.5 
                 49.5 
               
               
                   
               
               
                 233 
                 2901 
                 UCCUGGUCCCGGACCCGGG 
                 4237 
                 CCCGGGUCCGGGACCAGGA 
                 45.8 
                 43.8 
               
               
                   
               
               
                 234 
                 2902 
                 CCUGGUCCCGGACCCGGGA 
                 4238 
                 UCCCGGGUCCGGGACCAGG 
                 69.8 
                 67.8 
               
               
                   
               
               
                 235 
                 2903 
                 CUGGUCCCGGACCCGGGAG 
                 4239 
                 CUCCCGGGUCCGGGACCAG 
                 49.4 
                 47.4 
               
               
                   
               
               
                 236 
                 2904 
                 UGGUCCCGGACCCGGGAGC 
                 4240 
                 GCUCCCGGGUCCGGGACCA 
                 39.2 
                 37.2 
               
               
                   
               
               
                 237 
                 2905 
                 GGUCCCGGACCCGGGAGCG 
                 4241 
                 CGCUCCCGGGUCCGGGACC 
                 52 
                 50 
               
               
                   
               
               
                 238 
                 2906 
                 GUCCCGGACCCGGGAGCGA 
                 4242 
                 UCGCUCCCGGGUCCGGGAC 
                 68.7 
                 66.7 
               
               
                   
               
               
                 239 
                 2907 
                 UCCCGGACCCGGGAGCGAG 
                 4243 
                 CUCGCUCCCGGGUCCGGGA 
                 49.9 
                 47.9 
               
               
                   
               
               
                 240 
                 2908 
                 CCCGGACCCGGGAGCGAGG 
                 4244 
                 CCUCGCUCCCGGGUCCGGG 
                 56.2 
                 54.2 
               
               
                   
               
               
                 241 
                 2909 
                 CCGGACCCGGGAGCGAGGC 
                 4245 
                 GCCUCGCUCCCGGGUCCGG 
                 43.7 
                 41.7 
               
               
                   
               
               
                 242 
                 2910 
                 CGGACCCGGGAGCGAGGCA 
                 4246 
                 UGCCUCGCUCCCGGGUCCG 
                 70.6 
                 68.6 
               
               
                   
               
               
                 243 
                 2911 
                 GGACCCGGGAGCGAGGCAA 
                 4247 
                 UUGCCUCGCUCCCGGGUCC 
                 80.4 
                 78.4 
               
               
                   
               
               
                 244 
                 2912 
                 GACCCGGGAGCGAGGCAAA 
                 4248 
                 UUUGCCUCGCUCCCGGGUC 
                 85.2 
                 83.2 
               
               
                   
               
               
                 245 
                 2913 
                 ACCCGGGAGCGAGGCAAAG 
                 4249 
                 CUUUGCCUCGCUCCCGGGU 
                 58.6 
                 56.6 
               
               
                   
               
               
                 246 
                 2914 
                 CCCGGGAGCGAGGCAAAGG 
                 4250 
                 CCUUUGCCUCGCUCCCGGG 
                 55.6 
                 53.6 
               
               
                   
               
               
                 247 
                 2915 
                 CCGGGAGCGAGGCAAAGGU 
                 4251 
                 ACCUUUGCCUCGCUCCCGG 
                 68.9 
                 66.9 
               
               
                   
               
               
                 248 
                 2916 
                 CGGGAGCGAGGCAAAGGUC 
                 4252 
                 GACCUUUGCCUCGCUCCCG 
                 67.7 
                 65.7 
               
               
                   
               
               
                 249 
                 2917 
                 GGGAGCGAGGCAAAGGUCA 
                 4253 
                 UGACCUUUGCCUCGCUCCC 
                 84.3 
                 82.3 
               
               
                   
               
               
                 250 
                 2918 
                 GGAGCGAGGCAAAGGUCAC 
                 4254 
                 GUGACCUUUGCCUCGCUCC 
                 76.6 
                 74.6 
               
               
                   
               
               
                 251 
                 2919 
                 GAGCGAGGCAAAGGUCACC 
                 4255 
                 GGUGACCUUUGCCUCGCUC 
                 60.4 
                 58.4 
               
               
                   
               
               
                 252 
                 2920 
                 AGCGAGGCAAAGGUCACCC 
                 4256 
                 GGGUGACCUUUGCCUCGCU 
                 52.5 
                 50.5 
               
               
                   
               
               
                 253 
                 2921 
                 GCGAGGCAAAGGUCACCCG 
                 4257 
                 CGGGUGACCUUUGCCUCGC 
                 66.5 
                 64.5 
               
               
                   
               
               
                 254 
                 2922 
                 CGAGGCAAAGGUCACCCGG 
                 4258 
                 CCGGGUGACCUUUGCCUCG 
                 64.1 
                 62.1 
               
               
                   
               
               
                 255 
                 2923 
                 GAGGCAAAGGUCACCCGGA 
                 4259 
                 UCCGGGUGACCUUUGCCUC 
                 78.1 
                 76.1 
               
               
                   
               
               
                 256 
                 2924 
                 AGGCAAAGGUCACCCGGAG 
                 4260 
                 CUCCGGGUGACCUUUGCCU 
                 65.4 
                 63.4 
               
               
                   
               
               
                 257 
                 2925 
                 GGCAAAGGUCACCCGGAGU 
                 4261 
                 ACUCCGGGUGACCUUUGCC 
                 75.8 
                 73.8 
               
               
                   
               
               
                 258 
                 2926 
                 GCAAAGGUCACCCGGAGUU 
                 4262 
                 AACUCCGGGUGACCUUUGC 
                 79.5 
                 77.5 
               
               
                   
               
               
                 259 
                 2927 
                 CAAAGGUCACCCGGAGUUG 
                 4263 
                 CAACUCCGGGUGACCUUUG 
                 69.5 
                 67.5 
               
               
                   
               
               
                 260 
                 2928 
                 AAAGGUCACCCGGAGUUGU 
                 4264 
                 ACAACUCCGGGUGACCUUU 
                 68.3 
                 66.3 
               
               
                   
               
               
                 261 
                 2929 
                 AAGGUCACCCGGAGUUGUG 
                 4265 
                 CACAACUCCGGGUGACCUU 
                 62.2 
                 60.2 
               
               
                   
               
               
                 262 
                 2930 
                 AGGUCACCCGGAGUUGUGC 
                 4266 
                 GCACAACUCCGGGUGACCU 
                 56.9 
                 54.9 
               
               
                   
               
               
                 263 
                 2931 
                 GGUCACCCGGAGUUGUGCA 
                 4267 
                 UGCACAACUCCGGGUGACC 
                 82.6 
                 80.6 
               
               
                   
               
               
                 264 
                 2932 
                 GUCACCCGGAGUUGUGCAG 
                 4268 
                 CUGCACAACUCCGGGUGAC 
                 65.2 
                 63.2 
               
               
                   
               
               
                 265 
                 2933 
                 UCACCCGGAGUUGUGCAGA 
                 4269 
                 UCUGCACAACUCCGGGUGA 
                 66.2 
                 64.2 
               
               
                   
               
               
                 266 
                 2934 
                 CACCCGGAGUUGUGCAGAG 
                 4270 
                 CUCUGCACAACUCCGGGUG 
                 72.2 
                 70.2 
               
               
                   
               
               
                 267 
                 2935 
                 ACCCGGAGUUGUGCAGAGA 
                 4271 
                 UCUCUGCACAACUCCGGGU 
                 80.3 
                 78.3 
               
               
                   
               
               
                 268 
                 2936 
                 CCCGGAGUUGUGCAGAGAC 
                 4272 
                 GUCUCUGCACAACUCCGGG 
                 71 
                 69 
               
               
                   
               
               
                 269 
                 2937 
                 CCGGAGUUGUGCAGAGACC 
                 4273 
                 GGUCUCUGCACAACUCCGG 
                 71.6 
                 69.6 
               
               
                   
               
               
                 270 
                 2938 
                 CGGAGUUGUGCAGAGACCC 
                 4274 
                 GGGUCUCUGCACAACUCCG 
                 67.4 
                 65.4 
               
               
                   
               
               
                 271 
                 2939 
                 GGAGUUGUGCAGAGACCCG 
                 4275 
                 CGGGUCUCUGCACAACUCC 
                 75.5 
                 73.5 
               
               
                   
               
               
                 272 
                 2940 
                 GAGUUGUGCAGAGACCCGG 
                 4276 
                 CCGGGUCUCUGCACAACUC 
                 66.7 
                 64.7 
               
               
                   
               
               
                 273 
                 2941 
                 AGUUGUGCAGAGACCCGGC 
                 4277 
                 GCCGGGUCUCUGCACAACU 
                 63 
                 61 
               
               
                   
               
               
                 274 
                 2942 
                 GUUGUGCAGAGACCCGGCA 
                 4278 
                 UGCCGGGUCUCUGCACAAC 
                 78.6 
                 76.6 
               
               
                   
               
               
                 275 
                 2943 
                 UUGUGCAGAGACCCGGCAG 
                 4279 
                 CUGCCGGGUCUCUGCACAA 
                 55.4 
                 53.4 
               
               
                   
               
               
                 276 
                 2944 
                 UGUGCAGAGACCCGGCAGG 
                 4280 
                 CCUGCCGGGUCUCUGCACA 
                 55 
                 53 
               
               
                   
               
               
                 277 
                 2945 
                 GUGCAGAGACCCGGCAGGU 
                 4281 
                 ACCUGCCGGGUCUCUGCAC 
                 66.3 
                 64.3 
               
               
                   
               
               
                 278 
                 2946 
                 UGCAGAGACCCGGCAGGUG 
                 4282 
                 CACCUGCCGGGUCUCUGCA 
                 56.7 
                 54.7 
               
               
                   
               
               
                 279 
                 2947 
                 GCAGAGACCCGGCAGGUGC 
                 4283 
                 GCACCUGCCGGGUCUCUGC 
                 64.8 
                 62.8 
               
               
                   
               
               
                 280 
                 2948 
                 CAGAGACCCGGCAGGUGCU 
                 4284 
                 AGCACCUGCCGGGUCUCUG 
                 72.8 
                 70.8 
               
               
                   
               
               
                 281 
                 2949 
                 AGAGACCCGGCAGGUGCUG 
                 4285 
                 CAGCACCUGCCGGGUCUCU 
                 57.8 
                 55.8 
               
               
                   
               
               
                 282 
                 2950 
                 GAGACCCGGCAGGUGCUGG 
                 4286 
                 CCAGCACCUGCCGGGUCUC 
                 53.6 
                 51.6 
               
               
                   
               
               
                 283 
                 2951 
                 AGACCCGGCAGGUGCUGGG 
                 4287 
                 CCCAGCACCUGCCGGGUCU 
                 50.9 
                 48.9 
               
               
                   
               
               
                 308 
                 2952 
                 GGGAUAUAGCUUAAACCUA 
                 4288 
                 UAGGUUUAAGCUAUAUCCC 
                 94.8 
                 91.8 
               
               
                   
               
               
                 309 
                 2953 
                 GGAUAUAGCUUAAACCUAA 
                 4289 
                 UUAGGUUUAAGCUAUAUCC 
                 103 
                 100.3 
               
               
                   
               
               
                 310 
                 2954 
                 GAUAUAGCUUAAACCUAAU 
                 4290 
                 AUUAGGUUUAAGCUAUAUC 
                 90.2 
                 87.2 
               
               
                   
               
               
                 311 
                 2955 
                 AUAUAGCUUAAACCUAAUC 
                 4291 
                 GAUUAGGUUUAAGCUAUAU 
                 59.9 
                 56.9 
               
               
                   
               
               
                 312 
                 2956 
                 UAUAGCUUAAACCUAAUCC 
                 4292 
                 GGAUUAGGUUUAAGCUAUA 
                 50.2 
                 47.2 
               
               
                   
               
               
                 313 
                 2957 
                 AUAGCUUAAACCUAAUCCC 
                 4293 
                 GGGAUUAGGUUUAAGCUAU 
                 54.7 
                 51.7 
               
               
                   
               
               
                 314 
                 2958 
                 UAGCUUAAACCUAAUCCCU 
                 4294 
                 AGGGAUUAGGUUUAAGCUA 
                 66.5 
                 63.5 
               
               
                   
               
               
                 315 
                 2959 
                 AGCUUAAACCUAAUCCCUC 
                 4295 
                 GAGGGAUUAGGUUUAAGCU 
                 63.9 
                 60.9 
               
               
                   
               
               
                 316 
                 2960 
                 GCUUAAACCUAAUCCCUCC 
                 4296 
                 GGAGGGAUUAGGUUUAAGC 
                 68.5 
                 65.5 
               
               
                   
               
               
                 317 
                 2961 
                 CUUAAACCUAAUCCCUCCC 
                 4297 
                 GGGAGGGAUUAGGUUUAAG 
                 52.5 
                 49.5 
               
               
                   
               
               
                 318 
                 2962 
                 UUAAACCUAAUCCCUCCCG 
                 4298 
                 CGGGAGGGAUUAGGUUUAA 
                 39.9 
                 36.9 
               
               
                   
               
               
                 319 
                 2963 
                 UAAACCUAAUCCCUCCCGC 
                 4299 
                 GCGGGAGGGAUUAGGUUUA 
                 41.8 
                 38.8 
               
               
                   
               
               
                 320 
                 2964 
                 AAACCUAAUCCCUCCCGCC 
                 4300 
                 GGCGGGAGGGAUUAGGUUU 
                 45.5 
                 42.5 
               
               
                   
               
               
                 321 
                 2965 
                 AACCUAAUCCCUCCCGCCC 
                 4301 
                 GGGCGGGAGGGAUUAGGUU 
                 43.6 
                 40.6 
               
               
                   
               
               
                 322 
                 2966 
                 ACCUAAUCCCUCCCGCCCU 
                 4302 
                 AGGGCGGGAGGGAUUAGGU 
                 59.8 
                 56.8 
               
               
                   
               
               
                 323 
                 2967 
                 CCUAAUCCCUCCCGCCCUG 
                 4303 
                 CAGGGCGGGAGGGAUUAGG 
                 60.2 
                 57.2 
               
               
                   
               
               
                 324 
                 2968 
                 CUAAUCCCUCCCGCCCUGA 
                 4304 
                 UCAGGGCGGGAGGGAUUAG 
                 60.3 
                 57.3 
               
               
                   
               
               
                 325 
                 2969 
                 UAAUCCCUCCCGCCCUGAU 
                 4305 
                 AUCAGGGCGGGAGGGAUUA 
                 55.6 
                 52.6 
               
               
                   
               
               
                 326 
                 2970 
                 AAUCCCUCCCGCCCUGAUC 
                 4306 
                 GAUCAGGGCGGGAGGGAUU 
                 48 
                 45 
               
               
                   
               
               
                 327 
                 2971 
                 AUCCCUCCCGCCCUGAUCU 
                 4307 
                 AGAUCAGGGCGGGAGGGAU 
                 52.6 
                 49.6 
               
               
                   
               
               
                 328 
                 2972 
                 UCCCUCCCGCCCUGAUCUC 
                 4308 
                 GAGAUCAGGGCGGGAGGGA 
                 44 
                 41 
               
               
                   
               
               
                 329 
                 2973 
                 CCCUCCCGCCCUGAUCUCA 
                 4309 
                 UGAGAUCAGGGCGGGAGGG 
                 66.3 
                 63.3 
               
               
                   
               
               
                 330 
                 2974 
                 CCUCCCGCCCUGAUCUCAG 
                 4310 
                 CUGAGAUCAGGGCGGGAGG 
                 58.8 
                 55.8 
               
               
                   
               
               
                 331 
                 2975 
                 CUCCCGCCCUGAUCUCAGG 
                 4311 
                 CCUGAGAUCAGGGCGGGAG 
                 54.1 
                 51.1 
               
               
                   
               
               
                 332 
                 2976 
                 UCCCGCCCUGAUCUCAGGU 
                 4312 
                 ACCUGAGAUCAGGGCGGGA 
                 48.9 
                 45.9 
               
               
                   
               
               
                 333 
                 2977 
                 CCCGCCCUGAUCUCAGGUG 
                 4313 
                 CACCUGAGAUCAGGGCGGG 
                 54 
                 51 
               
               
                   
               
               
                 334 
                 2978 
                 CCGCCCUGAUCUCAGGUGA 
                 4314 
                 UCACCUGAGAUCAGGGCGG 
                 75.9 
                 72.9 
               
               
                   
               
               
                 335 
                 2979 
                 CGCCCUGAUCUCAGGUGAG 
                 4315 
                 CUCACCUGAGAUCAGGGCG 
                 67.4 
                 64.4 
               
               
                   
               
               
                 336 
                 2980 
                 GCCCUGAUCUCAGGUGAGC 
                 4316 
                 GCUCACCUGAGAUCAGGGC 
                 57.9 
                 54.9 
               
               
                   
               
               
                 337 
                 2981 
                 CCCUGAUCUCAGGUGAGCA 
                 4317 
                 UGCUCACCUGAGAUCAGGG 
                 75.6 
                 72.6 
               
               
                   
               
               
                 338 
                 2982 
                 CCUGAUCUCAGGUGAGCAC 
                 4318 
                 GUGCUCACCUGAGAUCAGG 
                 67.2 
                 64.2 
               
               
                   
               
               
                 339 
                 2983 
                 CUGAUCUCAGGUGAGCACC 
                 4319 
                 GGUGCUCACCUGAGAUCAG 
                 51.7 
                 48.7 
               
               
                   
               
               
                 340 
                 2984 
                 UGAUCUCAGGUGAGCACCU 
                 4320 
                 AGGUGCUCACCUGAGAUCA 
                 68.5 
                 65.5 
               
               
                   
               
               
                 341 
                 2985 
                 GAUCUCAGGUGAGCACCUC 
                 4321 
                 GAGGUGCUCACCUGAGAUC 
                 65.4 
                 62.4 
               
               
                   
               
               
                 342 
                 2986 
                 AUCUCAGGUGAGCACCUCC 
                 4322 
                 GGAGGUGCUCACCUGAGAU 
                 53 
                 50 
               
               
                   
               
               
                 343 
                 2987 
                 UCUCAGGUGAGCACCUCCG 
                 4323 
                 CGGAGGUGCUCACCUGAGA 
                 54.3 
                 51.3 
               
               
                   
               
               
                 344 
                 2988 
                 CUCAGGUGAGCACCUCCGG 
                 4324 
                 CCGGAGGUGCUCACCUGAG 
                 57.8 
                 54.8 
               
               
                   
               
               
                 345 
                 2989 
                 UCAGGUGAGCACCUCCGGG 
                 4325 
                 CCCGGAGGUGCUCACCUGA 
                 46.8 
                 43.8 
               
               
                   
               
               
                 346 
                 2990 
                 CAGGUGAGCACCUCCGGGU 
                 4326 
                 ACCCGGAGGUGCUCACCUG 
                 63.8 
                 60.8 
               
               
                   
               
               
                 347 
                 2991 
                 AGGUGAGCACCUCCGGGUC 
                 4327 
                 GACCCGGAGGUGCUCACCU 
                 59.3 
                 56.3 
               
               
                   
               
               
                 348 
                 2992 
                 GGUGAGCACCUCCGGGUCU 
                 4328 
                 AGACCCGGAGGUGCUCACC 
                 74.6 
                 71.6 
               
               
                   
               
               
                 349 
                 2993 
                 GUGAGCACCUCCGGGUCUG 
                 4329 
                 CAGACCCGGAGGUGCUCAC 
                 59.4 
                 56.4 
               
               
                   
               
               
                 350 
                 2994 
                 UGAGCACCUCCGGGUCUGU 
                 4330 
                 ACAGACCCGGAGGUGCUCA 
                 60.1 
                 57.1 
               
               
                   
               
               
                 351 
                 2995 
                 GAGCACCUCCGGGUCUGUC 
                 4331 
                 GACAGACCCGGAGGUGCUC 
                 55.9 
                 52.9 
               
               
                   
               
               
                 352 
                 2996 
                 AGCACCUCCGGGUCUGUCC 
                 4332 
                 GGACAGACCCGGAGGUGCU 
                 53.5 
                 50.5 
               
               
                   
               
               
                 353 
                 2997 
                 GCACCUCCGGGUCUGUCCC 
                 4333 
                 GGGACAGACCCGGAGGUGC 
                 57.9 
                 54.9 
               
               
                   
               
               
                 370 
                 2998 
                 CCCAGGAGUACACCUGCUG 
                 4334 
                 CAGCAGGUGUACUCCUGGG 
                 65.9 
                 62.9 
               
               
                   
               
               
                 371 
                 2999 
                 CCAGGAGUACACCUGCUGU 
                 4335 
                 ACAGCAGGUGUACUCCUGG 
                 75.8 
                 72.8 
               
               
                   
               
               
                 372 
                 3000 
                 CAGGAGUACACCUGCUGUU 
                 4336 
                 AACAGCAGGUGUACUCCUG 
                 81.1 
                 78.1 
               
               
                   
               
               
                 373 
                 3001 
                 AGGAGUACACCUGCUGUUC 
                 4337 
                 GAACAGCAGGUGUACUCCU 
                 67.2 
                 64.2 
               
               
                   
               
               
                 374 
                 3002 
                 GGAGUACACCUGCUGUUCC 
                 4338 
                 GGAACAGCAGGUGUACUCC 
                 70 
                 67 
               
               
                   
               
               
                 375 
                 3003 
                 GAGUACACCUGCUGUUCCA 
                 4339 
                 UGGAACAGCAGGUGUACUC 
                 89 
                 86 
               
               
                   
               
               
                 376 
                 3004 
                 AGUACACCUGCUGUUCCAG 
                 4340 
                 CUGGAACAGCAGGUGUACU 
                 66.4 
                 63.4 
               
               
                   
               
               
                 377 
                 3005 
                 GUACACCUGCUGUUCCAGU 
                 4341 
                 ACUGGAACAGCAGGUGUAC 
                 71.4 
                 68.4 
               
               
                   
               
               
                 378 
                 3006 
                 UACACCUGCUGUUCCAGUG 
                 4342 
                 CACUGGAACAGCAGGUGUA 
                 61.4 
                 58.4 
               
               
                   
               
               
                 379 
                 3007 
                 ACACCUGCUGUUCCAGUGA 
                 4343 
                 UCACUGGAACAGCAGGUGU 
                 80.6 
                 77.6 
               
               
                   
               
               
                 380 
                 3008 
                 CACCUGCUGUUCCAGUGAG 
                 4344 
                 CUCACUGGAACAGCAGGUG 
                 72.5 
                 69.5 
               
               
                   
               
               
                 381 
                 3009 
                 ACCUGCUGUUCCAGUGAGA 
                 4345 
                 UCUCACUGGAACAGCAGGU 
                 81.7 
                 78.7 
               
               
                   
               
               
                 382 
                 3010 
                 CCUGCUGUUCCAGUGAGAC 
                 4346 
                 GUCUCACUGGAACAGCAGG 
                 66.3 
                 63.3 
               
               
                   
               
               
                 383 
                 3011 
                 CUGCUGUUCCAGUGAGACA 
                 4347 
                 UGUCUCACUGGAACAGCAG 
                 84.8 
                 81.8 
               
               
                   
               
               
                 384 
                 3012 
                 UGCUGUUCCAGUGAGACAG 
                 4348 
                 CUGUCUCACUGGAACAGCA 
                 68.3 
                 65.3 
               
               
                   
               
               
                 385 
                 3013 
                 GCUGUUCCAGUGAGACAGA 
                 4349 
                 UCUGUCUCACUGGAACAGC 
                 91.8 
                 88.8 
               
               
                   
               
               
                 386 
                 3014 
                 CUGUUCCAGUGAGACAGAG 
                 4350 
                 CUCUGUCUCACUGGAACAG 
                 68.1 
                 65.1 
               
               
                   
               
               
                 387 
                 3015 
                 UGUUCCAGUGAGACAGAGC 
                 4351 
                 GCUCUGUCUCACUGGAACA 
                 60 
                 57 
               
               
                   
               
               
                 388 
                 3016 
                 GUUCCAGUGAGACAGAGCA 
                 4352 
                 UGCUCUGUCUCACUGGAAC 
                 84.3 
                 81.3 
               
               
                   
               
               
                 389 
                 3017 
                 UUCCAGUGAGACAGAGCAG 
                 4353 
                 CUGCUCUGUCUCACUGGAA 
                 62.3 
                 59.3 
               
               
                   
               
               
                 390 
                 3018 
                 UCCAGUGAGACAGAGCAGA 
                 4354 
                 UCUGCUCUGUCUCACUGGA 
                 72.7 
                 69.7 
               
               
                   
               
               
                 391 
                 3019 
                 CCAGUGAGACAGAGCAGAG 
                 4355 
                 CUCUGCUCUGUCUCACUGG 
                 74.9 
                 71.9 
               
               
                   
               
               
                 392 
                 3020 
                 CAGUGAGACAGAGCAGAGG 
                 4356 
                 CCUCUGCUCUGUCUCACUG 
                 65.9 
                 62.9 
               
               
                   
               
               
                 393 
                 3021 
                 AGUGAGACAGAGCAGAGGC 
                 4357 
                 GCCUCUGCUCUGUCUCACU 
                 61.3 
                 58.3 
               
               
                   
               
               
                 394 
                 3022 
                 GUGAGACAGAGCAGAGGCU 
                 4358 
                 AGCCUCUGCUCUGUCUCAC 
                 74 
                 71 
               
               
                   
               
               
                 395 
                 3023 
                 UGAGACAGAGCAGAGGCUG 
                 4359 
                 CAGCCUCUGCUCUGUCUCA 
                 59.2 
                 56.2 
               
               
                   
               
               
                 396 
                 3024 
                 GAGACAGAGCAGAGGCUGA 
                 4360 
                 UCAGCCUCUGCUCUGUCUC 
                 87 
                 84 
               
               
                   
               
               
                 397 
                 3025 
                 AGACAGAGCAGAGGCUGAU 
                 4361 
                 AUCAGCCUCUGCUCUGUCU 
                 77.2 
                 74.2 
               
               
                   
               
               
                 398 
                 3026 
                 GACAGAGCAGAGGCUGAUC 
                 4362 
                 GAUCAGCCUCUGCUCUGUC 
                 67.5 
                 64.5 
               
               
                   
               
               
                 399 
                 3027 
                 ACAGAGCAGAGGCUGAUCA 
                 4363 
                 UGAUCAGCCUCUGCUCUGU 
                 76.7 
                 73.7 
               
               
                   
               
               
                 400 
                 3028 
                 CAGAGCAGAGGCUGAUCAG 
                 4364 
                 CUGAUCAGCCUCUGCUCUG 
                 71.3 
                 67.3 
               
               
                   
               
               
                 401 
                 3029 
                 AGAGCAGAGGCUGAUCAGG 
                 4365 
                 CCUGAUCAGCCUCUGCUCU 
                 59.5 
                 55.5 
               
               
                   
               
               
                 402 
                 3030 
                 GAGCAGAGGCUGAUCAGGG 
                 4366 
                 CCCUGAUCAGCCUCUGCUC 
                 59.8 
                 55.8 
               
               
                   
               
               
                 403 
                 3031 
                 AGCAGAGGCUGAUCAGGGA 
                 4367 
                 UCCCUGAUCAGCCUCUGCU 
                 78.3 
                 74.3 
               
               
                   
               
               
                 404 
                 3032 
                 GCAGAGGCUGAUCAGGGAG 
                 4368 
                 CUCCCUGAUCAGCCUCUGC 
                 68.1 
                 64.1 
               
               
                   
               
               
                 405 
                 3033 
                 CAGAGGCUGAUCAGGGAGA 
                 4369 
                 UCUCCCUGAUCAGCCUCUG 
                 76.5 
                 72.5 
               
               
                   
               
               
                 406 
                 3034 
                 AGAGGCUGAUCAGGGAGAC 
                 4370 
                 GUCUCCCUGAUCAGCCUCU 
                 59.4 
                 55.4 
               
               
                   
               
               
                 407 
                 3035 
                 GAGGCUGAUCAGGGAGACU 
                 4371 
                 AGUCUCCCUGAUCAGCCUC 
                 70 
                 66 
               
               
                   
               
               
                 408 
                 3036 
                 AGGCUGAUCAGGGAGACUG 
                 4372 
                 CAGUCUCCCUGAUCAGCCU 
                 60.4 
                 56.4 
               
               
                   
               
               
                 409 
                 3037 
                 GGCUGAUCAGGGAGACUGA 
                 4373 
                 UCAGUCUCCCUGAUCAGCC 
                 88.9 
                 84.9 
               
               
                   
               
               
                 410 
                 3038 
                 GCUGAUCAGGGAGACUGAG 
                 4374 
                 CUCAGUCUCCCUGAUCAGC 
                 68.4 
                 64.4 
               
               
                   
               
               
                 411 
                 3039 
                 CUGAUCAGGGAGACUGAGG 
                 4375 
                 CCUCAGUCUCCCUGAUCAG 
                 53.5 
                 49.5 
               
               
                   
               
               
                 412 
                 3040 
                 UGAUCAGGGAGACUGAGGC 
                 4376 
                 GCCUCAGUCUCCCUGAUCA 
                 47.3 
                 43.3 
               
               
                   
               
               
                 413 
                 3041 
                 GAUCAGGGAGACUGAGGCC 
                 4377 
                 GGCCUCAGUCUCCCUGAUC 
                 56 
                 52 
               
               
                   
               
               
                 430 
                 3042 
                 CCACCUUCCGAGGCCUGGU 
                 4378 
                 ACCAGGCCUCGGAAGGUGG 
                 63.7 
                 59.7 
               
               
                   
               
               
                 431 
                 3043 
                 CACCUUCCGAGGCCUGGUG 
                 4379 
                 CACCAGGCCUCGGAAGGUG 
                 59.6 
                 55.6 
               
               
                   
               
               
                 432 
                 3044 
                 ACCUUCCGAGGCCUGGUGG 
                 4380 
                 CCACCAGGCCUCGGAAGGU 
                 49.4 
                 45.4 
               
               
                   
               
               
                 433 
                 3045 
                 CCUUCCGAGGCCUGGUGGA 
                 4381 
                 UCCACCAGGCCUCGGAAGG 
                 72.5 
                 68.5 
               
               
                   
               
               
                 434 
                 3046 
                 CUUCCGAGGCCUGGUGGAG 
                 4382 
                 CUCCACCAGGCCUCGGAAG 
                 56.1 
                 52.1 
               
               
                   
               
               
                 435 
                 3047 
                 UUCCGAGGCCUGGUGGAGG 
                 4383 
                 CCUCCACCAGGCCUCGGAA 
                 38.8 
                 34.8 
               
               
                   
               
               
                 436 
                 3048 
                 UCCGAGGCCUGGUGGAGGA 
                 4384 
                 UCCUCCACCAGGCCUCGGA 
                 66.5 
                 62.5 
               
               
                   
               
               
                 437 
                 3049 
                 CCGAGGCCUGGUGGAGGAC 
                 4385 
                 GUCCUCCACCAGGCCUCGG 
                 56.9 
                 52.9 
               
               
                   
               
               
                 438 
                 3050 
                 CGAGGCCUGGUGGAGGACA 
                 4386 
                 UGUCCUCCACCAGGCCUCG 
                 73.5 
                 69.5 
               
               
                   
               
               
                 439 
                 3051 
                 GAGGCCUGGUGGAGGACAG 
                 4387 
                 CUGUCCUCCACCAGGCCUC 
                 67 
                 63 
               
               
                   
               
               
                 440 
                 3052 
                 AGGCCUGGUGGAGGACAGC 
                 4388 
                 GCUGUCCUCCACCAGGCCU 
                 51.2 
                 47.2 
               
               
                   
               
               
                 441 
                 3053 
                 GGCCUGGUGGAGGACAGCG 
                 4389 
                 CGCUGUCCUCCACCAGGCC 
                 58.8 
                 54.8 
               
               
                   
               
               
                 442 
                 3054 
                 GCCUGGUGGAGGACAGCGG 
                 4390 
                 CCGCUGUCCUCCACCAGGC 
                 64.2 
                 60.2 
               
               
                   
               
               
                 443 
                 3055 
                 CCUGGUGGAGGACAGCGGC 
                 4391 
                 GCCGCUGUCCUCCACCAGG 
                 58.4 
                 54.4 
               
               
                   
               
               
                 444 
                 3056 
                 CUGGUGGAGGACAGCGGCU 
                 4392 
                 AGCCGCUGUCCUCCACCAG 
                 66.2 
                 62.2 
               
               
                   
               
               
                 445 
                 3057 
                 UGGUGGAGGACAGCGGCUC 
                 4393 
                 GAGCCGCUGUCCUCCACCA 
                 54.8 
                 50.8 
               
               
                   
               
               
                 446 
                 3058 
                 GGUGGAGGACAGCGGCUCC 
                 4394 
                 GGAGCCGCUGUCCUCCACC 
                 67.4 
                 63.4 
               
               
                   
               
               
                 447 
                 3059 
                 GUGGAGGACAGCGGCUCCU 
                 4395 
                 AGGAGCCGCUGUCCUCCAC 
                 67.1 
                 63.1 
               
               
                   
               
               
                 448 
                 3060 
                 UGGAGGACAGCGGCUCCUU 
                 4396 
                 AAGGAGCCGCUGUCCUCCA 
                 68 
                 64 
               
               
                   
               
               
                 449 
                 3061 
                 GGAGGACAGCGGCUCCUUU 
                 4397 
                 AAAGGAGCCGCUGUCCUCC 
                 83.2 
                 79.2 
               
               
                   
               
               
                 450 
                 3062 
                 GAGGACAGCGGCUCCUUUC 
                 4398 
                 GAAAGGAGCCGCUGUCCUC 
                 66.6 
                 62.6 
               
               
                   
               
               
                 451 
                 3063 
                 AGGACAGCGGCUCCUUUCU 
                 4399 
                 AGAAAGGAGCCGCUGUCCU 
                 71.8 
                 67.8 
               
               
                   
               
               
                 452 
                 3064 
                 GGACAGCGGCUCCUUUCUG 
                 4400 
                 CAGAAAGGAGCCGCUGUCC 
                 72.2 
                 68.2 
               
               
                   
               
               
                 453 
                 3065 
                 GACAGCGGCUCCUUUCUGG 
                 4401 
                 CCAGAAAGGAGCCGCUGUC 
                 62.8 
                 58.8 
               
               
                   
               
               
                 454 
                 3066 
                 ACAGCGGCUCCUUUCUGGU 
                 4402 
                 ACCAGAAAGGAGCCGCUGU 
                 64.8 
                 60.8 
               
               
                   
               
               
                 455 
                 3067 
                 CAGCGGCUCCUUUCUGGUU 
                 4403 
                 AACCAGAAAGGAGCCGCUG 
                 76.9 
                 72.9 
               
               
                   
               
               
                 456 
                 3068 
                 AGCGGCUCCUUUCUGGUUC 
                 4404 
                 GAACCAGAAAGGAGCCGCU 
                 62.8 
                 58.8 
               
               
                   
               
               
                 457 
                 3069 
                 GCGGCUCCUUUCUGGUUCA 
                 4405 
                 UGAACCAGAAAGGAGCCGC 
                 88.2 
                 84.2 
               
               
                   
               
               
                 458 
                 3070 
                 CGGCUCCUUUCUGGUUCAC 
                 4406 
                 GUGAACCAGAAAGGAGCCG 
                 65.9 
                 61.9 
               
               
                   
               
               
                 459 
                 3071 
                 GGCUCCUUUCUGGUUCACA 
                 4407 
                 UGUGAACCAGAAAGGAGCC 
                 80.4 
                 76.4 
               
               
                   
               
               
                 460 
                 3072 
                 GCUCCUUUCUGGUUCACAC 
                 4408 
                 GUGUGAACCAGAAAGGAGC 
                 76.2 
                 72.2 
               
               
                   
               
               
                 513 
                 3073 
                 UUUCUGGAGAUGCUCUCAG 
                 4409 
                 CUGAGAGCAUCUCCAGAAA 
                 55.3 
                 50.3 
               
               
                   
               
               
                 514 
                 3074 
                 UUCUGGAGAUGCUCUCAGU 
                 4410 
                 ACUGAGAGCAUCUCCAGAA 
                 69 
                 64 
               
               
                   
               
               
                 515 
                 3075 
                 UCUGGAGAUGCUCUCAGUA 
                 4411 
                 UACUGAGAGCAUCUCCAGA 
                 78.9 
                 73.9 
               
               
                   
               
               
                 516 
                 3076 
                 CUGGAGAUGCUCUCAGUAG 
                 4412 
                 CUACUGAGAGCAUCUCCAG 
                 73 
                 68 
               
               
                   
               
               
                 517 
                 3077 
                 UGGAGAUGCUCUCAGUAGC 
                 4413 
                 GCUACUGAGAGCAUCUCCA 
                 64.1 
                 59.1 
               
               
                   
               
               
                 518 
                 3078 
                 GGAGAUGCUCUCAGUAGCC 
                 4414 
                 GGCUACUGAGAGCAUCUCC 
                 68.6 
                 63.6 
               
               
                   
               
               
                 519 
                 3079 
                 GAGAUGCUCUCAGUAGCCC 
                 4415 
                 GGGCUACUGAGAGCAUCUC 
                 60.2 
                 55.2 
               
               
                   
               
               
                 520 
                 3080 
                 AGAUGCUCUCAGUAGCCCA 
                 4416 
                 UGGGCUACUGAGAGCAUCU 
                 81 
                 76 
               
               
                   
               
               
                 521 
                 3081 
                 GAUGCUCUCAGUAGCCCAG 
                 4417 
                 CUGGGCUACUGAGAGCAUC 
                 71.5 
                 66.5 
               
               
                   
               
               
                 522 
                 3082 
                 AUGCUCUCAGUAGCCCAGC 
                 4418 
                 GCUGGGCUACUGAGAGCAU 
                 43.7 
                 38.7 
               
               
                   
               
               
                 523 
                 3083 
                 UGCUCUCAGUAGCCCAGCA 
                 4419 
                 UGCUGGGCUACUGAGAGCA 
                 74.4 
                 69.4 
               
               
                   
               
               
                 524 
                 3084 
                 GCUCUCAGUAGCCCAGCAC 
                 4420 
                 GUGCUGGGCUACUGAGAGC 
                 65.2 
                 60.2 
               
               
                   
               
               
                 525 
                 3085 
                 CUCUCAGUAGCCCAGCACU 
                 4421 
                 AGUGCUGGGCUACUGAGAG 
                 69.9 
                 64.9 
               
               
                   
               
               
                 526 
                 3086 
                 UCUCAGUAGCCCAGCACUC 
                 4422 
                 GAGUGCUGGGCUACUGAGA 
                 57.8 
                 52.8 
               
               
                   
               
               
                 527 
                 3087 
                 CUCAGUAGCCCAGCACUCU 
                 4423 
                 AGAGUGCUGGGCUACUGAG 
                 67.5 
                 62.5 
               
               
                   
               
               
                 528 
                 3088 
                 UCAGUAGCCCAGCACUCUC 
                 4424 
                 GAGAGUGCUGGGCUACUGA 
                 57.4 
                 52.4 
               
               
                   
               
               
                 529 
                 3089 
                 CAGUAGCCCAGCACUCUCU 
                 4425 
                 AGAGAGUGCUGGGCUACUG 
                 73.5 
                 68.5 
               
               
                   
               
               
                 530 
                 3090 
                 AGUAGCCCAGCACUCUCUG 
                 4426 
                 CAGAGAGUGCUGGGCUACU 
                 61.1 
                 56.1 
               
               
                   
               
               
                 531 
                 3091 
                 GUAGCCCAGCACUCUCUGA 
                 4427 
                 UCAGAGAGUGCUGGGCUAC 
                 74.8 
                 69.8 
               
               
                   
               
               
                 532 
                 3092 
                 UAGCCCAGCACUCUCUGAC 
                 4428 
                 GUCAGAGAGUGCUGGGCUA 
                 47.3 
                 42.3 
               
               
                   
               
               
                 533 
                 3093 
                 AGCCCAGCACUCUCUGACC 
                 4429 
                 GGUCAGAGAGUGCUGGGCU 
                 55.5 
                 50.5 
               
               
                   
               
               
                 534 
                 3094 
                 GCCCAGCACUCUCUGACCC 
                 4430 
                 GGGUCAGAGAGUGCUGGGC 
                 58.1 
                 53.1 
               
               
                   
               
               
                 535 
                 3095 
                 CCCAGCACUCUCUGACCCA 
                 4431 
                 UGGGUCAGAGAGUGCUGGG 
                 75.1 
                 70.1 
               
               
                   
               
               
                 536 
                 3096 
                 CCAGCACUCUCUGACCCAG 
                 4432 
                 CUGGGUCAGAGAGUGCUGG 
                 67 
                 62 
               
               
                   
               
               
                 537 
                 3097 
                 CAGCACUCUCUGACCCAGC 
                 4433 
                 GCUGGGUCAGAGAGUGCUG 
                 57.1 
                 52.1 
               
               
                   
               
               
                 538 
                 3098 
                 AGCACUCUCUGACCCAGCU 
                 4434 
                 AGCUGGGUCAGAGAGUGCU 
                 70.9 
                 65.9 
               
               
                   
               
               
                 539 
                 3099 
                 GCACUCUCUGACCCAGCUC 
                 4435 
                 GAGCUGGGUCAGAGAGUGC 
                 65.2 
                 60.2 
               
               
                   
               
               
                 540 
                 3100 
                 CACUCUCUGACCCAGCUCU 
                 4436 
                 AGAGCUGGGUCAGAGAGUG 
                 72.1 
                 67.1 
               
               
                   
               
               
                 541 
                 3101 
                 ACUCUCUGACCCAGCUCUU 
                 4437 
                 AAGAGCUGGGUCAGAGAGU 
                 73 
                 68 
               
               
                   
               
               
                 542 
                 3102 
                 CUCUCUGACCCAGCUCUUC 
                 4438 
                 GAAGAGCUGGGUCAGAGAG 
                 61 
                 56 
               
               
                   
               
               
                 543 
                 3103 
                 UCUCUGACCCAGCUCUUCU 
                 4439 
                 AGAAGAGCUGGGUCAGAGA 
                 65 
                 60 
               
               
                   
               
               
                 544 
                 3104 
                 CUCUGACCCAGCUCUUCUC 
                 4440 
                 GAGAAGAGCUGGGUCAGAG 
                 63.7 
                 58.7 
               
               
                   
               
               
                 545 
                 3105 
                 UCUGACCCAGCUCUUCUCC 
                 4441 
                 GGAGAAGAGCUGGGUCAGA 
                 46.8 
                 41.8 
               
               
                   
               
               
                 546 
                 3106 
                 CUGACCCAGCUCUUCUCCC 
                 4442 
                 GGGAGAAGAGCUGGGUCAG 
                 50.1 
                 45.1 
               
               
                   
               
               
                 547 
                 3107 
                 UGACCCAGCUCUUCUCCCA 
                 4443 
                 UGGGAGAAGAGCUGGGUCA 
                 72 
                 67 
               
               
                   
               
               
                 548 
                 3108 
                 GACCCAGCUCUUCUCCCAC 
                 4444 
                 GUGGGAGAAGAGCUGGGUC 
                 64.9 
                 59.9 
               
               
                   
               
               
                 549 
                 3109 
                 ACCCAGCUCUUCUCCCACU 
                 4445 
                 AGUGGGAGAAGAGCUGGGU 
                 67.9 
                 62.9 
               
               
                   
               
               
                 550 
                 3110 
                 CCCAGCUCUUCUCCCACUC 
                 4446 
                 GAGUGGGAGAAGAGCUGGG 
                 63.1 
                 58.1 
               
               
                   
               
               
                 551 
                 3111 
                 CCAGCUCUUCUCCCACUCC 
                 4447 
                 GGAGUGGGAGAAGAGCUGG 
                 60.7 
                 55.7 
               
               
                   
               
               
                 552 
                 3112 
                 CAGCUCUUCUCCCACUCCU 
                 4448 
                 AGGAGUGGGAGAAGAGCUG 
                 72.9 
                 67.9 
               
               
                   
               
               
                 553 
                 3113 
                 AGCUCUUCUCCCACUCCUA 
                 4449 
                 UAGGAGUGGGAGAAGAGCU 
                 87.4 
                 82.4 
               
               
                   
               
               
                 554 
                 3114 
                 GCUCUUCUCCCACUCCUAC 
                 4450 
                 GUAGGAGUGGGAGAAGAGC 
                 70.5 
                 65.5 
               
               
                   
               
               
                 555 
                 3115 
                 CUCUUCUCCCACUCCUACG 
                 4451 
                 CGUAGGAGUGGGAGAAGAG 
                 59.4 
                 54.4 
               
               
                   
               
               
                 556 
                 3116 
                 UCUUCUCCCACUCCUACGG 
                 4452 
                 CCGUAGGAGUGGGAGAAGA 
                 52.1 
                 47.1 
               
               
                   
               
               
                 557 
                 3117 
                 CUUCUCCCACUCCUACGGC 
                 4453 
                 GCCGUAGGAGUGGGAGAAG 
                 47.5 
                 42.5 
               
               
                   
               
               
                 558 
                 3118 
                 UUCUCCCACUCCUACGGCC 
                 4454 
                 GGCCGUAGGAGUGGGAGAA 
                 39.7 
                 34.7 
               
               
                   
               
               
                 559 
                 3119 
                 UCUCCCACUCCUACGGCCG 
                 4455 
                 CGGCCGUAGGAGUGGGAGA 
                 46 
                 41 
               
               
                   
               
               
                 560 
                 3120 
                 CUCCCACUCCUACGGCCGC 
                 4456 
                 GCGGCCGUAGGAGUGGGAG 
                 47.5 
                 42.5 
               
               
                   
               
               
                 561 
                 3121 
                 UCCCACUCCUACGGCCGCC 
                 4457 
                 GGCGGCCGUAGGAGUGGGA 
                 34.9 
                 29.9 
               
               
                   
               
               
                 562 
                 3122 
                 CCCACUCCUACGGCCGCCU 
                 4458 
                 AGGCGGCCGUAGGAGUGGG 
                 55.9 
                 50.9 
               
               
                   
               
               
                 563 
                 3123 
                 CCACUCCUACGGCCGCCUG 
                 4459 
                 CAGGCGGCCGUAGGAGUGG 
                 56.4 
                 51.4 
               
               
                   
               
               
                 564 
                 3124 
                 CACUCCUACGGCCGCCUGU 
                 4460 
                 ACAGGCGGCCGUAGGAGUG 
                 63.9 
                 58.9 
               
               
                   
               
               
                 565 
                 3125 
                 ACUCCUACGGCCGCCUGUA 
                 4461 
                 UACAGGCGGCCGUAGGAGU 
                 69.9 
                 64.9 
               
               
                   
               
               
                 566 
                 3126 
                 CUCCUACGGCCGCCUGUAU 
                 4462 
                 AUACAGGCGGCCGUAGGAG 
                 68.7 
                 63.7 
               
               
                   
               
               
                 567 
                 3127 
                 UCCUACGGCCGCCUGUAUG 
                 4463 
                 CAUACAGGCGGCCGUAGGA 
                 50.2 
                 45.2 
               
               
                   
               
               
                 568 
                 3128 
                 CCUACGGCCGCCUGUAUGC 
                 4464 
                 GCAUACAGGCGGCCGUAGG 
                 54.5 
                 49.5 
               
               
                   
               
               
                 569 
                 3129 
                 CUACGGCCGCCUGUAUGCC 
                 4465 
                 GGCAUACAGGCGGCCGUAG 
                 43.2 
                 38.2 
               
               
                   
               
               
                 570 
                 3130 
                 UACGGCCGCCUGUAUGCCC 
                 4466 
                 GGGCAUACAGGCGGCCGUA 
                 36.1 
                 31.1 
               
               
                   
               
               
                 571 
                 3131 
                 ACGGCCGCCUGUAUGCCCA 
                 4467 
                 UGGGCAUACAGGCGGCCGU 
                 62.2 
                 57.2 
               
               
                   
               
               
                 572 
                 3132 
                 CGGCCGCCUGUAUGCCCAG 
                 4468 
                 CUGGGCAUACAGGCGGCCG 
                 59.8 
                 54.8 
               
               
                   
               
               
                 573 
                 3133 
                 GGCCGCCUGUAUGCCCAGC 
                 4469 
                 GCUGGGCAUACAGGCGGCC 
                 49 
                 44 
               
               
                   
               
               
                 574 
                 3134 
                 GCCGCCUGUAUGCCCAGCA 
                 4470 
                 UGCUGGGCAUACAGGCGGC 
                 66.7 
                 61.7 
               
               
                   
               
               
                 575 
                 3135 
                 CCGCCUGUAUGCCCAGCAC 
                 4471 
                 GUGCUGGGCAUACAGGCGG 
                 63.2 
                 58.2 
               
               
                   
               
               
                 576 
                 3136 
                 CGCCUGUAUGCCCAGCACG 
                 4472 
                 CGUGCUGGGCAUACAGGCG 
                 60.2 
                 55.2 
               
               
                   
               
               
                 577 
                 3137 
                 GCCUGUAUGCCCAGCACGC 
                 4473 
                 GCGUGCUGGGCAUACAGGC 
                 59.2 
                 54.2 
               
               
                   
               
               
                 578 
                 3138 
                 CCUGUAUGCCCAGCACGCC 
                 4474 
                 GGCGUGCUGGGCAUACAGG 
                 49.6 
                 44.6 
               
               
                   
               
               
                 579 
                 3139 
                 CUGUAUGCCCAGCACGCCC 
                 4475 
                 GGGCGUGCUGGGCAUACAG 
                 50.3 
                 45.3 
               
               
                   
               
               
                 580 
                 3140 
                 UGUAUGCCCAGCACGCCCU 
                 4476 
                 AGGGCGUGCUGGGCAUACA 
                 57.5 
                 52.5 
               
               
                   
               
               
                 581 
                 3141 
                 GUAUGCCCAGCACGCCCUC 
                 4477 
                 GAGGGCGUGCUGGGCAUAC 
                 53.3 
                 48.3 
               
               
                   
               
               
                 582 
                 3142 
                 UAUGCCCAGCACGCCCUCA 
                 4478 
                 UGAGGGCGUGCUGGGCAUA 
                 55.6 
                 50.6 
               
               
                   
               
               
                 583 
                 3143 
                 AUGCCCAGCACGCCCUCAU 
                 4479 
                 AUGAGGGCGUGCUGGGCAU 
                 56.7 
                 51.7 
               
               
                   
               
               
                 584 
                 3144 
                 UGCCCAGCACGCCCUCAUA 
                 4480 
                 UAUGAGGGCGUGCUGGGCA 
                 71.7 
                 66.7 
               
               
                   
               
               
                 585 
                 3145 
                 GCCCAGCACGCCCUCAUAU 
                 4481 
                 AUAUGAGGGCGUGCUGGGC 
                 71.9 
                 66.9 
               
               
                   
               
               
                 586 
                 3146 
                 CCCAGCACGCCCUCAUAUU 
                 4482 
                 AAUAUGAGGGCGUGCUGGG 
                 70.6 
                 65.6 
               
               
                   
               
               
                 587 
                 3147 
                 CCAGCACGCCCUCAUAUUC 
                 4483 
                 GAAUAUGAGGGCGUGCUGG 
                 62.6 
                 57.6 
               
               
                   
               
               
                 588 
                 3148 
                 CAGCACGCCCUCAUAUUCA 
                 4484 
                 UGAAUAUGAGGGCGUGCUG 
                 74.8 
                 69.8 
               
               
                   
               
               
                 589 
                 3149 
                 AGCACGCCCUCAUAUUCAA 
                 4485 
                 UUGAAUAUGAGGGCGUGCU 
                 85.4 
                 80.4 
               
               
                   
               
               
                 590 
                 3150 
                 GCACGCCCUCAUAUUCAAU 
                 4486 
                 AUUGAAUAUGAGGGCGUGC 
                 77.1 
                 72.1 
               
               
                   
               
               
                 591 
                 3151 
                 CACGCCCUCAUAUUCAAUG 
                 4487 
                 CAUUGAAUAUGAGGGCGUG 
                 58.6 
                 53.6 
               
               
                   
               
               
                 592 
                 3152 
                 ACGCCCUCAUAUUCAAUGG 
                 4488 
                 CCAUUGAAUAUGAGGGCGU 
                 56.9 
                 51.9 
               
               
                   
               
               
                 609 
                 3153 
                 GGCCUGUUCUCUCGGCUGC 
                 4489 
                 GCAGCCGAGAGAACAGGCC 
                 64.9 
                 58.9 
               
               
                   
               
               
                 610 
                 3154 
                 GCCUGUUCUCUCGGCUGCG 
                 4490 
                 CGCAGCCGAGAGAACAGGC 
                 62.3 
                 56.3 
               
               
                   
               
               
                 611 
                 3155 
                 CCUGUUCUCUCGGCUGCGA 
                 4491 
                 UCGCAGCCGAGAGAACAGG 
                 80.9 
                 74.9 
               
               
                   
               
               
                 612 
                 3156 
                 CUGUUCUCUCGGCUGCGAG 
                 4492 
                 CUCGCAGCCGAGAGAACAG 
                 63.8 
                 57.8 
               
               
                   
               
               
                 613 
                 3157 
                 UGUUCUCUCGGCUGCGAGA 
                 4493 
                 UCUCGCAGCCGAGAGAACA 
                 79.7 
                 73.7 
               
               
                   
               
               
                 614 
                 3158 
                 GUUCUCUCGGCUGCGAGAC 
                 4494 
                 GUCUCGCAGCCGAGAGAAC 
                 60.6 
                 54.6 
               
               
                   
               
               
                 615 
                 3159 
                 UUCUCUCGGCUGCGAGACU 
                 4495 
                 AGUCUCGCAGCCGAGAGAA 
                 61.3 
                 55.3 
               
               
                   
               
               
                 616 
                 3160 
                 UCUCUCGGCUGCGAGACUU 
                 4496 
                 AAGUCUCGCAGCCGAGAGA 
                 68.1 
                 62.1 
               
               
                   
               
               
                 617 
                 3161 
                 CUCUCGGCUGCGAGACUUC 
                 4497 
                 GAAGUCUCGCAGCCGAGAG 
                 67 
                 61 
               
               
                   
               
               
                 618 
                 3162 
                 UCUCGGCUGCGAGACUUCU 
                 4498 
                 AGAAGUCUCGCAGCCGAGA 
                 67.5 
                 61.5 
               
               
                   
               
               
                 619 
                 3163 
                 CUCGGCUGCGAGACUUCUA 
                 4499 
                 UAGAAGUCUCGCAGCCGAG 
                 85.8 
                 79.8 
               
               
                   
               
               
                 620 
                 3164 
                 UCGGCUGCGAGACUUCUAU 
                 4500 
                 AUAGAAGUCUCGCAGCCGA 
                 73.5 
                 67.5 
               
               
                   
               
               
                 621 
                 3165 
                 CGGCUGCGAGACUUCUAUG 
                 4501 
                 CAUAGAAGUCUCGCAGCCG 
                 76.6 
                 70.6 
               
               
                   
               
               
                 622 
                 3166 
                 GGCUGCGAGACUUCUAUGG 
                 4502 
                 CCAUAGAAGUCUCGCAGCC 
                 71.5 
                 65.5 
               
               
                   
               
               
                 623 
                 3167 
                 GCUGCGAGACUUCUAUGGG 
                 4503 
                 CCCAUAGAAGUCUCGCAGC 
                 68.4 
                 62.4 
               
               
                   
               
               
                 654 
                 3168 
                 GGGUUGGAUGACACCCUGG 
                 4504 
                 CCAGGGUGUCAUCCAACCC 
                 69.4 
                 63.4 
               
               
                   
               
               
                 671 
                 3169 
                 GGCGGAUUUCUGGGCACAG 
                 4505 
                 CUGUGCCCAGAAAUCCGCC 
                 67.2 
                 61.2 
               
               
                   
               
               
                 672 
                 3170 
                 GCGGAUUUCUGGGCACAGC 
                 4506 
                 GCUGUGCCCAGAAAUCCGC 
                 60.3 
                 54.3 
               
               
                   
               
               
                 673 
                 3171 
                 CGGAUUUCUGGGCACAGCU 
                 4507 
                 AGCUGUGCCCAGAAAUCCG 
                 72.2 
                 66.2 
               
               
                   
               
               
                 674 
                 3172 
                 GGAUUUCUGGGCACAGCUC 
                 4508 
                 GAGCUGUGCCCAGAAAUCC 
                 70 
                 64 
               
               
                   
               
               
                 675 
                 3173 
                 GAUUUCUGGGCACAGCUCC 
                 4509 
                 GGAGCUGUGCCCAGAAAUC 
                 58.3 
                 52.3 
               
               
                   
               
               
                 676 
                 3174 
                 AUUUCUGGGCACAGCUCCU 
                 4510 
                 AGGAGCUGUGCCCAGAAAU 
                 62.8 
                 56.8 
               
               
                   
               
               
                 677 
                 3175 
                 UUUCUGGGCACAGCUCCUG 
                 4511 
                 CAGGAGCUGUGCCCAGAAA 
                 45 
                 39 
               
               
                   
               
               
                 678 
                 3176 
                 UUCUGGGCACAGCUCCUGG 
                 4512 
                 CCAGGAGCUGUGCCCAGAA 
                 46.3 
                 40.3 
               
               
                   
               
               
                 679 
                 3177 
                 UCUGGGCACAGCUCCUGGA 
                 4513 
                 UCCAGGAGCUGUGCCCAGA 
                 65.8 
                 59.8 
               
               
                   
               
               
                 680 
                 3178 
                 CUGGGCACAGCUCCUGGAG 
                 4514 
                 CUCCAGGAGCUGUGCCCAG 
                 56.3 
                 50.3 
               
               
                   
               
               
                 681 
                 3179 
                 UGGGCACAGCUCCUGGAGA 
                 4515 
                 UCUCCAGGAGCUGUGCCCA 
                 68.2 
                 62.2 
               
               
                   
               
               
                 682 
                 3180 
                 GGGCACAGCUCCUGGAGAG 
                 4516 
                 CUCUCCAGGAGCUGUGCCC 
                 69.4 
                 63.4 
               
               
                   
               
               
                 683 
                 3181 
                 GGCACAGCUCCUGGAGAGA 
                 4517 
                 UCUCUCCAGGAGCUGUGCC 
                 82.4 
                 76.4 
               
               
                   
               
               
                 684 
                 3182 
                 GCACAGCUCCUGGAGAGAG 
                 4518 
                 CUCUCUCCAGGAGCUGUGC 
                 69.3 
                 63.3 
               
               
                   
               
               
                 685 
                 3183 
                 CACAGCUCCUGGAGAGAGU 
                 4519 
                 ACUCUCUCCAGGAGCUGUG 
                 75.9 
                 69.9 
               
               
                   
               
               
                 686 
                 3184 
                 ACAGCUCCUGGAGAGAGUG 
                 4520 
                 CACUCUCUCCAGGAGCUGU 
                 62.3 
                 56.3 
               
               
                   
               
               
                 687 
                 3185 
                 CAGCUCCUGGAGAGAGUGU 
                 4521 
                 ACACUCUCUCCAGGAGCUG 
                 73.3 
                 67.3 
               
               
                   
               
               
                 688 
                 3186 
                 AGCUCCUGGAGAGAGUGUU 
                 4522 
                 AACACUCUCUCCAGGAGCU 
                 74.9 
                 68.9 
               
               
                   
               
               
                 689 
                 3187 
                 GCUCCUGGAGAGAGUGUUC 
                 4523 
                 GAACACUCUCUCCAGGAGC 
                 76.9 
                 70.9 
               
               
                   
               
               
                 690 
                 3188 
                 CUCCUGGAGAGAGUGUUCC 
                 4524 
                 GGAACACUCUCUCCAGGAG 
                 56.9 
                 50.9 
               
               
                   
               
               
                 691 
                 3189 
                 UCCUGGAGAGAGUGUUCCC 
                 4525 
                 GGGAACACUCUCUCCAGGA 
                 57.6 
                 51.6 
               
               
                   
               
               
                 692 
                 3190 
                 CCUGGAGAGAGUGUUCCCG 
                 4526 
                 CGGGAACACUCUCUCCAGG 
                 61.3 
                 55.3 
               
               
                   
               
               
                 693 
                 3191 
                 CUGGAGAGAGUGUUCCCGC 
                 4527 
                 GCGGGAACACUCUCUCCAG 
                 56.6 
                 50.6 
               
               
                   
               
               
                 694 
                 3192 
                 UGGAGAGAGUGUUCCCGCU 
                 4528 
                 AGCGGGAACACUCUCUCCA 
                 71.5 
                 65.5 
               
               
                   
               
               
                 695 
                 3193 
                 GGAGAGAGUGUUCCCGCUG 
                 4529 
                 CAGCGGGAACACUCUCUCC 
                 75.5 
                 69.5 
               
               
                   
               
               
                 696 
                 3194 
                 GAGAGAGUGUUCCCGCUGC 
                 4530 
                 GCAGCGGGAACACUCUCUC 
                 67.8 
                 61.8 
               
               
                   
               
               
                 697 
                 3195 
                 AGAGAGUGUUCCCGCUGCU 
                 4531 
                 AGCAGCGGGAACACUCUCU 
                 76.9 
                 70.9 
               
               
                   
               
               
                 698 
                 3196 
                 GAGAGUGUUCCCGCUGCUG 
                 4532 
                 CAGCAGCGGGAACACUCUC 
                 69.4 
                 63.4 
               
               
                   
               
               
                 699 
                 3197 
                 AGAGUGUUCCCGCUGCUGC 
                 4533 
                 GCAGCAGCGGGAACACUCU 
                 60.3 
                 54.3 
               
               
                   
               
               
                 700 
                 3198 
                 GAGUGUUCCCGCUGCUGCA 
                 4534 
                 UGCAGCAGCGGGAACACUC 
                 86.8 
                 79.8 
               
               
                   
               
               
                 701 
                 3199 
                 AGUGUUCCCGCUGCUGCAC 
                 4535 
                 GUGCAGCAGCGGGAACACU 
                 61.8 
                 54.8 
               
               
                   
               
               
                 702 
                 3200 
                 GUGUUCCCGCUGCUGCACC 
                 4536 
                 GGUGCAGCAGCGGGAACAC 
                 54.1 
                 47.1 
               
               
                   
               
               
                 703 
                 3201 
                 UGUUCCCGCUGCUGCACCC 
                 4537 
                 GGGUGCAGCAGCGGGAACA 
                 52.9 
                 45.9 
               
               
                   
               
               
                 704 
                 3202 
                 GUUCCCGCUGCUGCACCCA 
                 4538 
                 UGGGUGCAGCAGCGGGAAC 
                 69.3 
                 62.3 
               
               
                   
               
               
                 705 
                 3203 
                 UUCCCGCUGCUGCACCCAC 
                 4539 
                 GUGGGUGCAGCAGCGGGAA 
                 47.3 
                 40.3 
               
               
                   
               
               
                 706 
                 3204 
                 UCCCGCUGCUGCACCCACA 
                 4540 
                 UGUGGGUGCAGCAGCGGGA 
                 68.5 
                 61.5 
               
               
                   
               
               
                 707 
                 3205 
                 CCCGCUGCUGCACCCACAG 
                 4541 
                 CUGUGGGUGCAGCAGCGGG 
                 64.6 
                 57.6 
               
               
                   
               
               
                 708 
                 3206 
                 CCGCUGCUGCACCCACAGU 
                 4542 
                 ACUGUGGGUGCAGCAGCGG 
                 70.4 
                 63.4 
               
               
                   
               
               
                 709 
                 3207 
                 CGCUGCUGCACCCACAGUA 
                 4543 
                 UACUGUGGGUGCAGCAGCG 
                 83.9 
                 76.9 
               
               
                   
               
               
                 710 
                 3208 
                 GCUGCUGCACCCACAGUAC 
                 4544 
                 GUACUGUGGGUGCAGCAGC 
                 74.2 
                 67.2 
               
               
                   
               
               
                 711 
                 3209 
                 CUGCUGCACCCACAGUACA 
                 4545 
                 UGUACUGUGGGUGCAGCAG 
                 79.4 
                 72.4 
               
               
                   
               
               
                 712 
                 3210 
                 UGCUGCACCCACAGUACAG 
                 4546 
                 CUGUACUGUGGGUGCAGCA 
                 64.7 
                 57.7 
               
               
                   
               
               
                 713 
                 3211 
                 GCUGCACCCACAGUACAGC 
                 4547 
                 GCUGUACUGUGGGUGCAGC 
                 58.4 
                 51.4 
               
               
                   
               
               
                 714 
                 3212 
                 CUGCACCCACAGUACAGCU 
                 4548 
                 AGCUGUACUGUGGGUGCAG 
                 67.7 
                 60.7 
               
               
                   
               
               
                 715 
                 3213 
                 UGCACCCACAGUACAGCUU 
                 4549 
                 AAGCUGUACUGUGGGUGCA 
                 70.2 
                 63.2 
               
               
                   
               
               
                 716 
                 3214 
                 GCACCCACAGUACAGCUUC 
                 4550 
                 GAAGCUGUACUGUGGGUGC 
                 70.3 
                 63.3 
               
               
                   
               
               
                 717 
                 3215 
                 CACCCACAGUACAGCUUCC 
                 4551 
                 GGAAGCUGUACUGUGGGUG 
                 67 
                 60 
               
               
                   
               
               
                 718 
                 3216 
                 ACCCACAGUACAGCUUCCC 
                 4552 
                 GGGAAGCUGUACUGUGGGU 
                 49.1 
                 42.1 
               
               
                   
               
               
                 737 
                 3217 
                 CCCUGACUACCUGCUCUGC 
                 4553 
                 GCAGAGCAGGUAGUCAGGG 
                 59.5 
                 52.5 
               
               
                   
               
               
                 738 
                 3218 
                 CCUGACUACCUGCUCUGCC 
                 4554 
                 GGCAGAGCAGGUAGUCAGG 
                 54.5 
                 47.5 
               
               
                   
               
               
                 739 
                 3219 
                 CUGACUACCUGCUCUGCCU 
                 4555 
                 AGGCAGAGCAGGUAGUCAG 
                 72 
                 65 
               
               
                   
               
               
                 740 
                 3220 
                 UGACUACCUGCUCUGCCUC 
                 4556 
                 GAGGCAGAGCAGGUAGUCA 
                 56.6 
                 49.6 
               
               
                   
               
               
                 741 
                 3221 
                 GACUACCUGCUCUGCCUCU 
                 4557 
                 AGAGGCAGAGCAGGUAGUC 
                 73.1 
                 66.1 
               
               
                   
               
               
                 742 
                 3222 
                 ACUACCUGCUCUGCCUCUC 
                 4558 
                 GAGAGGCAGAGCAGGUAGU 
                 56.7 
                 49.7 
               
               
                   
               
               
                 743 
                 3223 
                 CUACCUGCUCUGCCUCUCA 
                 4559 
                 UGAGAGGCAGAGCAGGUAG 
                 77.8 
                 70.8 
               
               
                   
               
               
                 744 
                 3224 
                 UACCUGCUCUGCCUCUCAC 
                 4560 
                 GUGAGAGGCAGAGCAGGUA 
                 56 
                 49 
               
               
                   
               
               
                 745 
                 3225 
                 ACCUGCUCUGCCUCUCACG 
                 4561 
                 CGUGAGAGGCAGAGCAGGU 
                 55.2 
                 48.2 
               
               
                   
               
               
                 746 
                 3226 
                 CCUGCUCUGCCUCUCACGC 
                 4562 
                 GCGUGAGAGGCAGAGCAGG 
                 54.3 
                 47.3 
               
               
                   
               
               
                 747 
                 3227 
                 CUGCUCUGCCUCUCACGCU 
                 4563 
                 AGCGUGAGAGGCAGAGCAG 
                 62.6 
                 55.6 
               
               
                   
               
               
                 748 
                 3228 
                 UGCUCUGCCUCUCACGCUU 
                 4564 
                 AAGCGUGAGAGGCAGAGCA 
                 73 
                 66 
               
               
                   
               
               
                 749 
                 3229 
                 GCUCUGCCUCUCACGCUUG 
                 4565 
                 CAAGCGUGAGAGGCAGAGC 
                 70.9 
                 63.9 
               
               
                   
               
               
                 750 
                 3230 
                 CUCUGCCUCUCACGCUUGG 
                 4566 
                 CCAAGCGUGAGAGGCAGAG 
                 57.8 
                 50.8 
               
               
                   
               
               
                 783 
                 3231 
                 GGCUCUCUGCAGCCCUUUG 
                 4567 
                 CAAAGGGCUGCAGAGAGCC 
                 71.6 
                 64.6 
               
               
                   
               
               
                 784 
                 3232 
                 GCUCUCUGCAGCCCUUUGG 
                 4568 
                 CCAAAGGGCUGCAGAGAGC 
                 60.5 
                 53.5 
               
               
                   
               
               
                 785 
                 3233 
                 CUCUCUGCAGCCCUUUGGG 
                 4569 
                 CCCAAAGGGCUGCAGAGAG 
                 50.4 
                 43.4 
               
               
                   
               
               
                 811 
                 3234 
                 CCCGCCGCCUCCGCCUGCA 
                 4570 
                 UGCAGGCGGAGGCGGCGGG 
                 57.3 
                 49.3 
               
               
                   
               
               
                 812 
                 3235 
                 CCGCCGCCUCCGCCUGCAG 
                 4571 
                 CUGCAGGCGGAGGCGGCGG 
                 53.3 
                 45.3 
               
               
                   
               
               
                 813 
                 3236 
                 CGCCGCCUCCGCCUGCAGA 
                 4572 
                 UCUGCAGGCGGAGGCGGCG 
                 66.1 
                 58.1 
               
               
                   
               
               
                 814 
                 3237 
                 GCCGCCUCCGCCUGCAGAU 
                 4573 
                 AUCUGCAGGCGGAGGCGGC 
                 66.9 
                 58.9 
               
               
                   
               
               
                 815 
                 3238 
                 CCGCCUCCGCCUGCAGAUA 
                 4574 
                 UAUCUGCAGGCGGAGGCGG 
                 74.5 
                 66.5 
               
               
                   
               
               
                 816 
                 3239 
                 CGCCUCCGCCUGCAGAUAA 
                 4575 
                 UUAUCUGCAGGCGGAGGCG 
                 80.1 
                 72.1 
               
               
                   
               
               
                 817 
                 3240 
                 GCCUCCGCCUGCAGAUAAC 
                 4576 
                 GUUAUCUGCAGGCGGAGGC 
                 66.1 
                 58.1 
               
               
                   
               
               
                 818 
                 3241 
                 CCUCCGCCUGCAGAUAACC 
                 4577 
                 GGUUAUCUGCAGGCGGAGG 
                 53.1 
                 45.1 
               
               
                   
               
               
                 819 
                 3242 
                 CUCCGCCUGCAGAUAACCC 
                 4578 
                 GGGUUAUCUGCAGGCGGAG 
                 48.2 
                 40.2 
               
               
                   
               
               
                 820 
                 3243 
                 UCCGCCUGCAGAUAACCCG 
                 4579 
                 CGGGUUAUCUGCAGGCGGA 
                 45.8 
                 37.8 
               
               
                   
               
               
                 821 
                 3244 
                 CCGCCUGCAGAUAACCCGG 
                 4580 
                 CCGGGUUAUCUGCAGGCGG 
                 58.2 
                 50.2 
               
               
                   
               
               
                 822 
                 3245 
                 CGCCUGCAGAUAACCCGGA 
                 4581 
                 UCCGGGUUAUCUGCAGGCG 
                 73.7 
                 65.7 
               
               
                   
               
               
                 823 
                 3246 
                 GCCUGCAGAUAACCCGGAC 
                 4582 
                 GUCCGGGUUAUCUGCAGGC 
                 65.5 
                 57.5 
               
               
                   
               
               
                 824 
                 3247 
                 CCUGCAGAUAACCCGGACC 
                 4583 
                 GGUCCGGGUUAUCUGCAGG 
                 57.6 
                 49.6 
               
               
                   
               
               
                 825 
                 3248 
                 CUGCAGAUAACCCGGACCC 
                 4584 
                 GGGUCCGGGUUAUCUGCAG 
                 53.2 
                 45.2 
               
               
                   
               
               
                 826 
                 3249 
                 UGCAGAUAACCCGGACCCU 
                 4585 
                 AGGGUCCGGGUUAUCUGCA 
                 62.9 
                 54.9 
               
               
                   
               
               
                 827 
                 3250 
                 GCAGAUAACCCGGACCCUG 
                 4586 
                 CAGGGUCCGGGUUAUCUGC 
                 66.7 
                 58.7 
               
               
                   
               
               
                 828 
                 3251 
                 CAGAUAACCCGGACCCUGG 
                 4587 
                 CCAGGGUCCGGGUUAUCUG 
                 61.3 
                 53.3 
               
               
                   
               
               
                 829 
                 3252 
                 AGAUAACCCGGACCCUGGU 
                 4588 
                 ACCAGGGUCCGGGUUAUCU 
                 67.4 
                 59.4 
               
               
                   
               
               
                 830 
                 3253 
                 GAUAACCCGGACCCUGGUG 
                 4589 
                 CACCAGGGUCCGGGUUAUC 
                 59.2 
                 51.2 
               
               
                   
               
               
                 831 
                 3254 
                 AUAACCCGGACCCUGGUGG 
                 4590 
                 CCACCAGGGUCCGGGUUAU 
                 40.4 
                 32.4 
               
               
                   
               
               
                 848 
                 3255 
                 GGCUGCCCGAGCCUUUGUG 
                 4591 
                 CACAAAGGCUCGGGCAGCC 
                 62.5 
                 54.5 
               
               
                   
               
               
                 849 
                 3256 
                 GCUGCCCGAGCCUUUGUGC 
                 4592 
                 GCACAAAGGCUCGGGCAGC 
                 55.7 
                 47.7 
               
               
                   
               
               
                 850 
                 3257 
                 CUGCCCGAGCCUUUGUGCA 
                 4593 
                 UGCACAAAGGCUCGGGCAG 
                 68 
                 60 
               
               
                   
               
               
                 851 
                 3258 
                 UGCCCGAGCCUUUGUGCAG 
                 4594 
                 CUGCACAAAGGCUCGGGCA 
                 59.8 
                 51.8 
               
               
                   
               
               
                 852 
                 3259 
                 GCCCGAGCCUUUGUGCAGG 
                 4595 
                 CCUGCACAAAGGCUCGGGC 
                 59.3 
                 51.3 
               
               
                   
               
               
                 853 
                 3260 
                 CCCGAGCCUUUGUGCAGGG 
                 4596 
                 CCCUGCACAAAGGCUCGGG 
                 58 
                 50 
               
               
                   
               
               
                 854 
                 3261 
                 CCGAGCCUUUGUGCAGGGC 
                 4597 
                 GCCCUGCACAAAGGCUCGG 
                 50 
                 42 
               
               
                   
               
               
                 855 
                 3262 
                 CGAGCCUUUGUGCAGGGCC 
                 4598 
                 GGCCCUGCACAAAGGCUCG 
                 52.5 
                 44.5 
               
               
                   
               
               
                 856 
                 3263 
                 GAGCCUUUGUGCAGGGCCU 
                 4599 
                 AGGCCCUGCACAAAGGCUC 
                 71 
                 63 
               
               
                   
               
               
                 857 
                 3264 
                 AGCCUUUGUGCAGGGCCUG 
                 4600 
                 CAGGCCCUGCACAAAGGCU 
                 54.6 
                 46.6 
               
               
                   
               
               
                 858 
                 3265 
                 GCCUUUGUGCAGGGCCUGG 
                 4601 
                 CCAGGCCCUGCACAAAGGC 
                 54.8 
                 46.8 
               
               
                   
               
               
                 859 
                 3266 
                 CCUUUGUGCAGGGCCUGGA 
                 4602 
                 UCCAGGCCCUGCACAAAGG 
                 69.4 
                 61.4 
               
               
                   
               
               
                 860 
                 3267 
                 CUUUGUGCAGGGCCUGGAG 
                 4603 
                 CUCCAGGCCCUGCACAAAG 
                 59.8 
                 51.8 
               
               
                   
               
               
                 861 
                 3268 
                 UUUGUGCAGGGCCUGGAGA 
                 4604 
                 UCUCCAGGCCCUGCACAAA 
                 58.5 
                 50.5 
               
               
                   
               
               
                 862 
                 3269 
                 UUGUGCAGGGCCUGGAGAC 
                 4605 
                 GUCUCCAGGCCCUGCACAA 
                 45.8 
                 37.8 
               
               
                   
               
               
                 863 
                 3270 
                 UGUGCAGGGCCUGGAGACU 
                 4606 
                 AGUCUCCAGGCCCUGCACA 
                 59.3 
                 51.3 
               
               
                   
               
               
                 864 
                 3271 
                 GUGCAGGGCCUGGAGACUG 
                 4607 
                 CAGUCUCCAGGCCCUGCAC 
                 58.3 
                 50.3 
               
               
                   
               
               
                 865 
                 3272 
                 UGCAGGGCCUGGAGACUGG 
                 4608 
                 CCAGUCUCCAGGCCCUGCA 
                 54.8 
                 46.8 
               
               
                   
               
               
                 866 
                 3273 
                 GCAGGGCCUGGAGACUGGA 
                 4609 
                 UCCAGUCUCCAGGCCCUGC 
                 73.5 
                 65.5 
               
               
                   
               
               
                 867 
                 3274 
                 CAGGGCCUGGAGACUGGAA 
                 4610 
                 UUCCAGUCUCCAGGCCCUG 
                 75.3 
                 67.3 
               
               
                   
               
               
                 868 
                 3275 
                 AGGGCCUGGAGACUGGAAG 
                 4611 
                 CUUCCAGUCUCCAGGCCCU 
                 55.4 
                 47.4 
               
               
                   
               
               
                 869 
                 3276 
                 GGGCCUGGAGACUGGAAGA 
                 4612 
                 UCUUCCAGUCUCCAGGCCC 
                 81.8 
                 73.8 
               
               
                   
               
               
                 870 
                 3277 
                 GGCCUGGAGACUGGAAGAA 
                 4613 
                 UUCUUCCAGUCUCCAGGCC 
                 83.1 
                 75.1 
               
               
                   
               
               
                 871 
                 3278 
                 GCCUGGAGACUGGAAGAAA 
                 4614 
                 UUUCUUCCAGUCUCCAGGC 
                 89 
                 81 
               
               
                   
               
               
                 872 
                 3279 
                 CCUGGAGACUGGAAGAAAU 
                 4615 
                 AUUUCUUCCAGUCUCCAGG 
                 87.9 
                 79.9 
               
               
                   
               
               
                 873 
                 3280 
                 CUGGAGACUGGAAGAAAUG 
                 4616 
                 CAUUUCUUCCAGUCUCCAG 
                 70.4 
                 62.4 
               
               
                   
               
               
                 874 
                 3281 
                 UGGAGACUGGAAGAAAUGU 
                 4617 
                 ACAUUUCUUCCAGUCUCCA 
                 69.7 
                 61.7 
               
               
                   
               
               
                 875 
                 3282 
                 GGAGACUGGAAGAAAUGUG 
                 4618 
                 CACAUUUCUUCCAGUCUCC 
                 76.2 
                 68.2 
               
               
                   
               
               
                 876 
                 3283 
                 GAGACUGGAAGAAAUGUGG 
                 4619 
                 CCACAUUUCUUCCAGUCUC 
                 71.5 
                 63.5 
               
               
                   
               
               
                 877 
                 3284 
                 AGACUGGAAGAAAUGUGGU 
                 4620 
                 ACCACAUUUCUUCCAGUCU 
                 75.1 
                 67.1 
               
               
                   
               
               
                 878 
                 3285 
                 GACUGGAAGAAAUGUGGUC 
                 4621 
                 GACCACAUUUCUUCCAGUC 
                 70.9 
                 62.9 
               
               
                   
               
               
                 879 
                 3286 
                 ACUGGAAGAAAUGUGGUCA 
                 4622 
                 UGACCACAUUUCUUCCAGU 
                 76.1 
                 68.1 
               
               
                   
               
               
                 880 
                 3287 
                 CUGGAAGAAAUGUGGUCAG 
                 4623 
                 CUGACCACAUUUCUUCCAG 
                 70.2 
                 62.2 
               
               
                   
               
               
                 881 
                 3288 
                 UGGAAGAAAUGUGGUCAGC 
                 4624 
                 GCUGACCACAUUUCUUCCA 
                 58.3 
                 50.3 
               
               
                   
               
               
                 882 
                 3289 
                 GGAAGAAAUGUGGUCAGCG 
                 4625 
                 CGCUGACCACAUUUCUUCC 
                 67.6 
                 59.6 
               
               
                   
               
               
                 883 
                 3290 
                 GAAGAAAUGUGGUCAGCGA 
                 4626 
                 UCGCUGACCACAUUUCUUC 
                 93.7 
                 85.7 
               
               
                   
               
               
                 884 
                 3291 
                 AAGAAAUGUGGUCAGCGAA 
                 4627 
                 UUCGCUGACCACAUUUCUU 
                 88.1 
                 80.1 
               
               
                   
               
               
                 885 
                 3292 
                 AGAAAUGUGGUCAGCGAAG 
                 4628 
                 CUUCGCUGACCACAUUUCU 
                 74.9 
                 66.9 
               
               
                   
               
               
                 886 
                 3293 
                 GAAAUGUGGUCAGCGAAGC 
                 4629 
                 GCUUCGCUGACCACAUUUC 
                 66.5 
                 58.5 
               
               
                   
               
               
                 887 
                 3294 
                 AAAUGUGGUCAGCGAAGCG 
                 4630 
                 CGCUUCGCUGACCACAUUU 
                 64.1 
                 56.1 
               
               
                   
               
               
                 888 
                 3295 
                 AAUGUGGUCAGCGAAGCGC 
                 4631 
                 GCGCUUCGCUGACCACAUU 
                 54 
                 46 
               
               
                   
               
               
                 889 
                 3296 
                 AUGUGGUCAGCGAAGCGCU 
                 4632 
                 AGCGCUUCGCUGACCACAU 
                 70.5 
                 62.5 
               
               
                   
               
               
                 890 
                 3297 
                 UGUGGUCAGCGAAGCGCUU 
                 4633 
                 AAGCGCUUCGCUGACCACA 
                 79.3 
                 71.3 
               
               
                   
               
               
                 891 
                 3298 
                 GUGGUCAGCGAAGCGCUUA 
                 4634 
                 UAAGCGCUUCGCUGACCAC 
                 82.8 
                 74.8 
               
               
                   
               
               
                 892 
                 3299 
                 UGGUCAGCGAAGCGCUUAA 
                 4635 
                 UUAAGCGCUUCGCUGACCA 
                 85.5 
                 77.5 
               
               
                   
               
               
                 893 
                 3300 
                 GGUCAGCGAAGCGCUUAAG 
                 4636 
                 CUUAAGCGCUUCGCUGACC 
                 76.2 
                 68.2 
               
               
                   
               
               
                 894 
                 3301 
                 GUCAGCGAAGCGCUUAAGG 
                 4637 
                 CCUUAAGCGCUUCGCUGAC 
                 60.7 
                 52.7 
               
               
                   
               
               
                 895 
                 3302 
                 UCAGCGAAGCGCUUAAGGU 
                 4638 
                 ACCUUAAGCGCUUCGCUGA 
                 66.1 
                 58.1 
               
               
                   
               
               
                 896 
                 3303 
                 CAGCGAAGCGCUUAAGGUG 
                 4639 
                 CACCUUAAGCGCUUCGCUG 
                 72.5 
                 64.5 
               
               
                   
               
               
                 897 
                 3304 
                 AGCGAAGCGCUUAAGGUGC 
                 4640 
                 GCACCUUAAGCGCUUCGCU 
                 63.8 
                 55.8 
               
               
                   
               
               
                 898 
                 3305 
                 GCGAAGCGCUUAAGGUGCC 
                 4641 
                 GGCACCUUAAGCGCUUCGC 
                 65.7 
                 57.7 
               
               
                   
               
               
                 899 
                 3306 
                 CGAAGCGCUUAAGGUGCCG 
                 4642 
                 CGGCACCUUAAGCGCUUCG 
                 62.7 
                 54.7 
               
               
                   
               
               
                 900 
                 3307 
                 GAAGCGCUUAAGGUGCCGG 
                 4643 
                 CCGGCACCUUAAGCGCUUC 
                 55 
                 46 
               
               
                   
               
               
                 901 
                 3308 
                 AAGCGCUUAAGGUGCCGGU 
                 4644 
                 ACCGGCACCUUAAGCGCUU 
                 60.4 
                 51.4 
               
               
                   
               
               
                 902 
                 3309 
                 AGCGCUUAAGGUGCCGGUG 
                 4645 
                 CACCGGCACCUUAAGCGCU 
                 59.7 
                 50.7 
               
               
                   
               
               
                 903 
                 3310 
                 GCGCUUAAGGUGCCGGUGU 
                 4646 
                 ACACCGGCACCUUAAGCGC 
                 74.3 
                 65.3 
               
               
                   
               
               
                 904 
                 3311 
                 CGCUUAAGGUGCCGGUGUC 
                 4647 
                 GACACCGGCACCUUAAGCG 
                 70.1 
                 61.1 
               
               
                   
               
               
                 905 
                 3312 
                 GCUUAAGGUGCCGGUGUCU 
                 4648 
                 AGACACCGGCACCUUAAGC 
                 75.4 
                 66.4 
               
               
                   
               
               
                 906 
                 3313 
                 CUUAAGGUGCCGGUGUCUG 
                 4649 
                 CAGACACCGGCACCUUAAG 
                 60.2 
                 51.2 
               
               
                   
               
               
                 907 
                 3314 
                 UUAAGGUGCCGGUGUCUGA 
                 4650 
                 UCAGACACCGGCACCUUAA 
                 69.5 
                 60.5 
               
               
                   
               
               
                 908 
                 3315 
                 UAAGGUGCCGGUGUCUGAA 
                 4651 
                 UUCAGACACCGGCACCUUA 
                 71.8 
                 62.8 
               
               
                   
               
               
                 909 
                 3316 
                 AAGGUGCCGGUGUCUGAAG 
                 4652 
                 CUUCAGACACCGGCACCUU 
                 61.7 
                 52.7 
               
               
                   
               
               
                 910 
                 3317 
                 AGGUGCCGGUGUCUGAAGG 
                 4653 
                 CCUUCAGACACCGGCACCU 
                 58.5 
                 49.5 
               
               
                   
               
               
                 911 
                 3318 
                 GGUGCCGGUGUCUGAAGGC 
                 4654 
                 GCCUUCAGACACCGGCACC 
                 58 
                 49 
               
               
                   
               
               
                 912 
                 3319 
                 GUGCCGGUGUCUGAAGGCU 
                 4655 
                 AGCCUUCAGACACCGGCAC 
                 67.5 
                 58.5 
               
               
                   
               
               
                 913 
                 3320 
                 UGCCGGUGUCUGAAGGCUG 
                 4656 
                 CAGCCUUCAGACACCGGCA 
                 61.7 
                 52.7 
               
               
                   
               
               
                 914 
                 3321 
                 GCCGGUGUCUGAAGGCUGC 
                 4657 
                 GCAGCCUUCAGACACCGGC 
                 66.1 
                 57.1 
               
               
                   
               
               
                 915 
                 3322 
                 CCGGUGUCUGAAGGCUGCA 
                 4658 
                 UGCAGCCUUCAGACACCGG 
                 76.3 
                 67.3 
               
               
                   
               
               
                 916 
                 3323 
                 CGGUGUCUGAAGGCUGCAG 
                 4659 
                 CUGCAGCCUUCAGACACCG 
                 69.4 
                 60.4 
               
               
                   
               
               
                 917 
                 3324 
                 GGUGUCUGAAGGCUGCAGC 
                 4660 
                 GCUGCAGCCUUCAGACACC 
                 61.4 
                 52.4 
               
               
                   
               
               
                 918 
                 3325 
                 GUGUCUGAAGGCUGCAGCC 
                 4661 
                 GGCUGCAGCCUUCAGACAC 
                 58.6 
                 49.6 
               
               
                   
               
               
                 935 
                 3326 
                 CCAGGCUCUGAUGCGUCUC 
                 4662 
                 GAGACGCAUCAGAGCCUGG 
                 59.8 
                 50.8 
               
               
                   
               
               
                 936 
                 3327 
                 CAGGCUCUGAUGCGUCUCA 
                 4663 
                 UGAGACGCAUCAGAGCCUG 
                 78.3 
                 69.3 
               
               
                   
               
               
                 937 
                 3328 
                 AGGCUCUGAUGCGUCUCAU 
                 4664 
                 AUGAGACGCAUCAGAGCCU 
                 73.1 
                 64.1 
               
               
                   
               
               
                 938 
                 3329 
                 GGCUCUGAUGCGUCUCAUC 
                 4665 
                 GAUGAGACGCAUCAGAGCC 
                 72.1 
                 63.1 
               
               
                   
               
               
                 939 
                 3330 
                 GCUCUGAUGCGUCUCAUCG 
                 4666 
                 CGAUGAGACGCAUCAGAGC 
                 67.3 
                 58.3 
               
               
                   
               
               
                 940 
                 3331 
                 CUCUGAUGCGUCUCAUCGG 
                 4667 
                 CCGAUGAGACGCAUCAGAG 
                 61.4 
                 52.4 
               
               
                   
               
               
                 941 
                 3332 
                 UCUGAUGCGUCUCAUCGGC 
                 4668 
                 GCCGAUGAGACGCAUCAGA 
                 49.6 
                 40.6 
               
               
                   
               
               
                 942 
                 3333 
                 CUGAUGCGUCUCAUCGGCU 
                 4669 
                 AGCCGAUGAGACGCAUCAG 
                 63.4 
                 54.4 
               
               
                   
               
               
                 943 
                 3334 
                 UGAUGCGUCUCAUCGGCUG 
                 4670 
                 CAGCCGAUGAGACGCAUCA 
                 61.2 
                 52.2 
               
               
                   
               
               
                 944 
                 3335 
                 GAUGCGUCUCAUCGGCUGU 
                 4671 
                 ACAGCCGAUGAGACGCAUC 
                 75.6 
                 66.6 
               
               
                   
               
               
                 945 
                 3336 
                 AUGCGUCUCAUCGGCUGUC 
                 4672 
                 GACAGCCGAUGAGACGCAU 
                 49.5 
                 40.5 
               
               
                   
               
               
                 946 
                 3337 
                 UGCGUCUCAUCGGCUGUCC 
                 4673 
                 GGACAGCCGAUGAGACGCA 
                 48.5 
                 39.5 
               
               
                   
               
               
                 947 
                 3338 
                 GCGUCUCAUCGGCUGUCCC 
                 4674 
                 GGGACAGCCGAUGAGACGC 
                 60.6 
                 51.6 
               
               
                   
               
               
                 981 
                 3339 
                 CCCUCACUUAUGCCCUGCC 
                 4675 
                 GGCAGGGCAUAAGUGAGGG 
                 50.7 
                 41.7 
               
               
                   
               
               
                 998 
                 3340 
                 CCAGGGCUUCUGCCUCAAC 
                 4676 
                 GUUGAGGCAGAAGCCCUGG 
                 61.8 
                 52.8 
               
               
                   
               
               
                 999 
                 3341 
                 CAGGGCUUCUGCCUCAACG 
                 4677 
                 CGUUGAGGCAGAAGCCCUG 
                 57.8 
                 48.8 
               
               
                   
               
               
                 1000 
                 3342 
                 AGGGCUUCUGCCUCAACGU 
                 4678 
                 ACGUUGAGGCAGAAGCCCU 
                 65.7 
                 55.7 
               
               
                   
               
               
                 1001 
                 3343 
                 GGGCUUCUGCCUCAACGUG 
                 4679 
                 CACGUUGAGGCAGAAGCCC 
                 66.8 
                 56.8 
               
               
                   
               
               
                 1002 
                 3344 
                 GGCUUCUGCCUCAACGUGG 
                 4680 
                 CCACGUUGAGGCAGAAGCC 
                 64.3 
                 54.3 
               
               
                   
               
               
                 1003 
                 3345 
                 GCUUCUGCCUCAACGUGGU 
                 4681 
                 ACCACGUUGAGGCAGAAGC 
                 77.4 
                 67.4 
               
               
                   
               
               
                 1004 
                 3346 
                 CUUCUGCCUCAACGUGGUU 
                 4682 
                 AACCACGUUGAGGCAGAAG 
                 72.3 
                 62.3 
               
               
                   
               
               
                 1005 
                 3347 
                 UUCUGCCUCAACGUGGUUC 
                 4683 
                 GAACCACGUUGAGGCAGAA 
                 43.5 
                 33.5 
               
               
                   
               
               
                 1006 
                 3348 
                 UCUGCCUCAACGUGGUUCG 
                 4684 
                 CGAACCACGUUGAGGCAGA 
                 50.9 
                 40.9 
               
               
                   
               
               
                 1007 
                 3349 
                 CUGCCUCAACGUGGUUCGU 
                 4685 
                 ACGAACCACGUUGAGGCAG 
                 64.3 
                 54.3 
               
               
                   
               
               
                 1008 
                 3350 
                 UGCCUCAACGUGGUUCGUG 
                 4686 
                 CACGAACCACGUUGAGGCA 
                 48.7 
                 38.7 
               
               
                   
               
               
                 1009 
                 3351 
                 GCCUCAACGUGGUUCGUGG 
                 4687 
                 CCACGAACCACGUUGAGGC 
                 66.3 
                 56.3 
               
               
                   
               
               
                 1026 
                 3352 
                 GGCUGUCUCAGCAGCAGGG 
                 4688 
                 CCCUGCUGCUGAGACAGCC 
                 65.7 
                 55.7 
               
               
                   
               
               
                 1043 
                 3353 
                 GGGACUGGAGCCUGACUGG 
                 4689 
                 CCAGUCAGGCUCCAGUCCC 
                 63.3 
                 53.3 
               
               
                   
               
               
                 1044 
                 3354 
                 GGACUGGAGCCUGACUGGG 
                 4690 
                 CCCAGUCAGGCUCCAGUCC 
                 57.5 
                 47.5 
               
               
                   
               
               
                 1061 
                 3355 
                 GGGCAACUAUCUGGAUGGU 
                 4691 
                 ACCAUCCAGAUAGUUGCCC 
                 75.4 
                 65.4 
               
               
                   
               
               
                 1062 
                 3356 
                 GGCAACUAUCUGGAUGGUC 
                 4692 
                 GACCAUCCAGAUAGUUGCC 
                 65 
                 55 
               
               
                   
               
               
                 1063 
                 3357 
                 GCAACUAUCUGGAUGGUCU 
                 4693 
                 AGACCAUCCAGAUAGUUGC 
                 83.5 
                 73.5 
               
               
                   
               
               
                 1064 
                 3358 
                 CAACUAUCUGGAUGGUCUC 
                 4694 
                 GAGACCAUCCAGAUAGUUG 
                 71.7 
                 61.7 
               
               
                   
               
               
                 1065 
                 3359 
                 AACUAUCUGGAUGGUCUCC 
                 4695 
                 GGAGACCAUCCAGAUAGUU 
                 53.7 
                 43.7 
               
               
                   
               
               
                 1066 
                 3360 
                 ACUAUCUGGAUGGUCUCCU 
                 4696 
                 AGGAGACCAUCCAGAUAGU 
                 60.9 
                 50.9 
               
               
                   
               
               
                 1067 
                 3361 
                 CUAUCUGGAUGGUCUCCUG 
                 4697 
                 CAGGAGACCAUCCAGAUAG 
                 71.8 
                 61.8 
               
               
                   
               
               
                 1068 
                 3362 
                 UAUCUGGAUGGUCUCCUGA 
                 4698 
                 UCAGGAGACCAUCCAGAUA 
                 70.3 
                 60.3 
               
               
                   
               
               
                 1069 
                 3363 
                 AUCUGGAUGGUCUCCUGAU 
                 4699 
                 AUCAGGAGACCAUCCAGAU 
                 71.8 
                 61.8 
               
               
                   
               
               
                 1070 
                 3364 
                 UCUGGAUGGUCUCCUGAUC 
                 4700 
                 GAUCAGGAGACCAUCCAGA 
                 61.4 
                 51.4 
               
               
                   
               
               
                 1071 
                 3365 
                 CUGGAUGGUCUCCUGAUCC 
                 4701 
                 GGAUCAGGAGACCAUCCAG 
                 57.1 
                 47.1 
               
               
                   
               
               
                 1072 
                 3366 
                 UGGAUGGUCUCCUGAUCCU 
                 4702 
                 AGGAUCAGGAGACCAUCCA 
                 70.7 
                 60.7 
               
               
                   
               
               
                 1073 
                 3367 
                 GGAUGGUCUCCUGAUCCUG 
                 4703 
                 CAGGAUCAGGAGACCAUCC 
                 74.2 
                 64.2 
               
               
                   
               
               
                 1074 
                 3368 
                 GAUGGUCUCCUGAUCCUGG 
                 4704 
                 CCAGGAUCAGGAGACCAUC 
                 65.9 
                 55.9 
               
               
                   
               
               
                 1091 
                 3369 
                 GGCUGAUAAGCUCCAGGGC 
                 4705 
                 GCCCUGGAGCUUAUCAGCC 
                 61.2 
                 51.2 
               
               
                   
               
               
                 1092 
                 3370 
                 GCUGAUAAGCUCCAGGGCC 
                 4706 
                 GGCCCUGGAGCUUAUCAGC 
                 56.9 
                 46.9 
               
               
                   
               
               
                 1093 
                 3371 
                 CUGAUAAGCUCCAGGGCCC 
                 4707 
                 GGGCCCUGGAGCUUAUCAG 
                 51.4 
                 41.4 
               
               
                   
               
               
                 1114 
                 3372 
                 UUUCCUUUGAGCUGACGGC 
                 4708 
                 GCCGUCAGCUCAAAGGAAA 
                 42.5 
                 31.5 
               
               
                   
               
               
                 1115 
                 3373 
                 UUCCUUUGAGCUGACGGCC 
                 4709 
                 GGCCGUCAGCUCAAAGGAA 
                 37.3 
                 26.3 
               
               
                   
               
               
                 1116 
                 3374 
                 UCCUUUGAGCUGACGGCCG 
                 4710 
                 CGGCCGUCAGCUCAAAGGA 
                 49.1 
                 38.1 
               
               
                   
               
               
                 1117 
                 3375 
                 CCUUUGAGCUGACGGCCGA 
                 4711 
                 UCGGCCGUCAGCUCAAAGG 
                 80.5 
                 69.5 
               
               
                   
               
               
                 1118 
                 3376 
                 CUUUGAGCUGACGGCCGAG 
                 4712 
                 CUCGGCCGUCAGCUCAAAG 
                 58.9 
                 47.9 
               
               
                   
               
               
                 1119 
                 3377 
                 UUUGAGCUGACGGCCGAGU 
                 4713 
                 ACUCGGCCGUCAGCUCAAA 
                 49.9 
                 38.9 
               
               
                   
               
               
                 1120 
                 3378 
                 UUGAGCUGACGGCCGAGUC 
                 4714 
                 GACUCGGCCGUCAGCUCAA 
                 47.5 
                 36.5 
               
               
                   
               
               
                 1121 
                 3379 
                 UGAGCUGACGGCCGAGUCC 
                 4715 
                 GGACUCGGCCGUCAGCUCA 
                 53.5 
                 42.5 
               
               
                   
               
               
                 1122 
                 3380 
                 GAGCUGACGGCCGAGUCCA 
                 4716 
                 UGGACUCGGCCGUCAGCUC 
                 77 
                 66 
               
               
                   
               
               
                 1123 
                 3381 
                 AGCUGACGGCCGAGUCCAU 
                 4717 
                 AUGGACUCGGCCGUCAGCU 
                 76.9 
                 65.9 
               
               
                   
               
               
                 1124 
                 3382 
                 GCUGACGGCCGAGUCCAUU 
                 4718 
                 AAUGGACUCGGCCGUCAGC 
                 71.9 
                 60.9 
               
               
                   
               
               
                 1125 
                 3383 
                 CUGACGGCCGAGUCCAUUG 
                 4719 
                 CAAUGGACUCGGCCGUCAG 
                 62.8 
                 51.8 
               
               
                   
               
               
                 1126 
                 3384 
                 UGACGGCCGAGUCCAUUGG 
                 4720 
                 CCAAUGGACUCGGCCGUCA 
                 55.1 
                 44.1 
               
               
                   
               
               
                 1127 
                 3385 
                 GACGGCCGAGUCCAUUGGG 
                 4721 
                 CCCAAUGGACUCGGCCGUC 
                 54.9 
                 43.9 
               
               
                   
               
               
                 1144 
                 3386 
                 GGGUGAAGAUCUCGGAGGG 
                 4722 
                 CCCUCCGAGAUCUUCACCC 
                 66.3 
                 55.3 
               
               
                   
               
               
                 1145 
                 3387 
                 GGUGAAGAUCUCGGAGGGU 
                 4723 
                 ACCCUCCGAGAUCUUCACC 
                 71.7 
                 60.7 
               
               
                   
               
               
                 1146 
                 3388 
                 GUGAAGAUCUCGGAGGGUU 
                 4724 
                 AACCCUCCGAGAUCUUCAC 
                 74.9 
                 63.9 
               
               
                   
               
               
                 1147 
                 3389 
                 UGAAGAUCUCGGAGGGUUU 
                 4725 
                 AAACCCUCCGAGAUCUUCA 
                 75.5 
                 64.5 
               
               
                   
               
               
                 1148 
                 3390 
                 GAAGAUCUCGGAGGGUUUG 
                 4726 
                 CAAACCCUCCGAGAUCUUC 
                 69.2 
                 58.2 
               
               
                   
               
               
                 1149 
                 3391 
                 AAGAUCUCGGAGGGUUUGA 
                 4727 
                 UCAAACCCUCCGAGAUCUU 
                 68.2 
                 57.2 
               
               
                   
               
               
                 1150 
                 3392 
                 AGAUCUCGGAGGGUUUGAU 
                 4728 
                 AUCAAACCCUCCGAGAUCU 
                 71.3 
                 60.3 
               
               
                   
               
               
                 1151 
                 3393 
                 GAUCUCGGAGGGUUUGAUG 
                 4729 
                 CAUCAAACCCUCCGAGAUC 
                 65.5 
                 54.5 
               
               
                   
               
               
                 1152 
                 3394 
                 AUCUCGGAGGGUUUGAUGU 
                 4730 
                 ACAUCAAACCCUCCGAGAU 
                 63.4 
                 52.4 
               
               
                   
               
               
                 1153 
                 3395 
                 UCUCGGAGGGUUUGAUGUA 
                 4731 
                 UACAUCAAACCCUCCGAGA 
                 76.8 
                 65.8 
               
               
                   
               
               
                 1154 
                 3396 
                 CUCGGAGGGUUUGAUGUAC 
                 4732 
                 GUACAUCAAACCCUCCGAG 
                 63.5 
                 52.5 
               
               
                   
               
               
                 1155 
                 3397 
                 UCGGAGGGUUUGAUGUACC 
                 4733 
                 GGUACAUCAAACCCUCCGA 
                 53.1 
                 42.1 
               
               
                   
               
               
                 1156 
                 3398 
                 CGGAGGGUUUGAUGUACCU 
                 4734 
                 AGGUACAUCAAACCCUCCG 
                 80.7 
                 69.7 
               
               
                   
               
               
                 1157 
                 3399 
                 GGAGGGUUUGAUGUACCUG 
                 4735 
                 CAGGUACAUCAAACCCUCC 
                 70.9 
                 59.9 
               
               
                   
               
               
                 1158 
                 3400 
                 GAGGGUUUGAUGUACCUGC 
                 4736 
                 GCAGGUACAUCAAACCCUC 
                 64.1 
                 53.1 
               
               
                   
               
               
                 1159 
                 3401 
                 AGGGUUUGAUGUACCUGCA 
                 4737 
                 UGCAGGUACAUCAAACCCU 
                 83.8 
                 72.8 
               
               
                   
               
               
                 1160 
                 3402 
                 GGGUUUGAUGUACCUGCAG 
                 4738 
                 CUGCAGGUACAUCAAACCC 
                 76.6 
                 65.6 
               
               
                   
               
               
                 1161 
                 3403 
                 GGUUUGAUGUACCUGCAGG 
                 4739 
                 CCUGCAGGUACAUCAAACC 
                 73.4 
                 62.4 
               
               
                   
               
               
                 1162 
                 3404 
                 GUUUGAUGUACCUGCAGGA 
                 4740 
                 UCCUGCAGGUACAUCAAAC 
                 82.5 
                 71.5 
               
               
                   
               
               
                 1163 
                 3405 
                 UUUGAUGUACCUGCAGGAA 
                 4741 
                 UUCCUGCAGGUACAUCAAA 
                 71.2 
                 60.2 
               
               
                   
               
               
                 1164 
                 3406 
                 UUGAUGUACCUGCAGGAAA 
                 4742 
                 UUUCCUGCAGGUACAUCAA 
                 76.2 
                 65.2 
               
               
                   
               
               
                 1181 
                 3407 
                 AAACAGUGCGAAGGUGUCC 
                 4743 
                 GGACACCUUCGCACUGUUU 
                 58.4 
                 47.4 
               
               
                   
               
               
                 1182 
                 3408 
                 AACAGUGCGAAGGUGUCCG 
                 4744 
                 CGGACACCUUCGCACUGUU 
                 56.5 
                 45.5 
               
               
                   
               
               
                 1183 
                 3409 
                 ACAGUGCGAAGGUGUCCGC 
                 4745 
                 GCGGACACCUUCGCACUGU 
                 58.4 
                 47.4 
               
               
                   
               
               
                 1184 
                 3410 
                 CAGUGCGAAGGUGUCCGCC 
                 4746 
                 GGCGGACACCUUCGCACUG 
                 53.4 
                 42.4 
               
               
                   
               
               
                 1185 
                 3411 
                 AGUGCGAAGGUGUCCGCCC 
                 4747 
                 GGGCGGACACCUUCGCACU 
                 57.5 
                 46.5 
               
               
                   
               
               
                 1186 
                 3412 
                 GUGCGAAGGUGUCCGCCCA 
                 4748 
                 UGGGCGGACACCUUCGCAC 
                 81.4 
                 70.4 
               
               
                   
               
               
                 1187 
                 3413 
                 UGCGAAGGUGUCCGCCCAG 
                 4749 
                 CUGGGCGGACACCUUCGCA 
                 60.1 
                 49.1 
               
               
                   
               
               
                 1188 
                 3414 
                 GCGAAGGUGUCCGCCCAGG 
                 4750 
                 CCUGGGCGGACACCUUCGC 
                 61 
                 50 
               
               
                   
               
               
                 1189 
                 3415 
                 CGAAGGUGUCCGCCCAGGU 
                 4751 
                 ACCUGGGCGGACACCUUCG 
                 72.1 
                 61.1 
               
               
                   
               
               
                 1190 
                 3416 
                 GAAGGUGUCCGCCCAGGUG 
                 4752 
                 CACCUGGGCGGACACCUUC 
                 66.1 
                 55.1 
               
               
                   
               
               
                 1191 
                 3417 
                 AAGGUGUCCGCCCAGGUGU 
                 4753 
                 ACACCUGGGCGGACACCUU 
                 63.9 
                 52.9 
               
               
                   
               
               
                 1192 
                 3418 
                 AGGUGUCCGCCCAGGUGUU 
                 4754 
                 AACACCUGGGCGGACACCU 
                 75.8 
                 64.8 
               
               
                   
               
               
                 1193 
                 3419 
                 GGUGUCCGCCCAGGUGUUU 
                 4755 
                 AAACACCUGGGCGGACACC 
                 74.8 
                 63.8 
               
               
                   
               
               
                 1194 
                 3420 
                 GUGUCCGCCCAGGUGUUUC 
                 4756 
                 GAAACACCUGGGCGGACAC 
                 56.9 
                 45.9 
               
               
                   
               
               
                 1195 
                 3421 
                 UGUCCGCCCAGGUGUUUCA 
                 4757 
                 UGAAACACCUGGGCGGACA 
                 73.1 
                 62.1 
               
               
                   
               
               
                 1196 
                 3422 
                 GUCCGCCCAGGUGUUUCAG 
                 4758 
                 CUGAAACACCUGGGCGGAC 
                 58.2 
                 47.2 
               
               
                   
               
               
                 1197 
                 3423 
                 UCCGCCCAGGUGUUUCAGG 
                 4759 
                 CCUGAAACACCUGGGCGGA 
                 43.4 
                 32.4 
               
               
                   
               
               
                 1198 
                 3424 
                 CCGCCCAGGUGUUUCAGGA 
                 4760 
                 UCCUGAAACACCUGGGCGG 
                 73.3 
                 62.3 
               
               
                   
               
               
                 1199 
                 3425 
                 CGCCCAGGUGUUUCAGGAG 
                 4761 
                 CUCCUGAAACACCUGGGCG 
                 67.1 
                 56.1 
               
               
                   
               
               
                 1200 
                 3426 
                 GCCCAGGUGUUUCAGGAGU 
                 4762 
                 ACUCCUGAAACACCUGGGC 
                 76.4 
                 64.4 
               
               
                   
               
               
                 1201 
                 3427 
                 CCCAGGUGUUUCAGGAGUG 
                 4763 
                 CACUCCUGAAACACCUGGG 
                 72 
                 60 
               
               
                   
               
               
                 1202 
                 3428 
                 CCAGGUGUUUCAGGAGUGC 
                 4764 
                 GCACUCCUGAAACACCUGG 
                 64.8 
                 52.8 
               
               
                   
               
               
                 1203 
                 3429 
                 CAGGUGUUUCAGGAGUGCG 
                 4765 
                 CGCACUCCUGAAACACCUG 
                 64 
                 52 
               
               
                   
               
               
                 1204 
                 3430 
                 AGGUGUUUCAGGAGUGCGG 
                 4766 
                 CCGCACUCCUGAAACACCU 
                 66.4 
                 54.4 
               
               
                   
               
               
                 1205 
                 3431 
                 GGUGUUUCAGGAGUGCGGC 
                 4767 
                 GCCGCACUCCUGAAACACC 
                 62.1 
                 50.1 
               
               
                   
               
               
                 1206 
                 3432 
                 GUGUUUCAGGAGUGCGGCC 
                 4768 
                 GGCCGCACUCCUGAAACAC 
                 56.9 
                 44.9 
               
               
                   
               
               
                 1207 
                 3433 
                 UGUUUCAGGAGUGCGGCCC 
                 4769 
                 GGGCCGCACUCCUGAAACA 
                 44 
                 32 
               
               
                   
               
               
                 1227 
                 3434 
                 CCCGACCCGGUGCCUGCCC 
                 4770 
                 GGGCAGGCACCGGGUCGGG 
                 45.8 
                 33.8 
               
               
                   
               
               
                 1228 
                 3435 
                 CCGACCCGGUGCCUGCCCG 
                 4771 
                 CGGGCAGGCACCGGGUCGG 
                 51.8 
                 39.8 
               
               
                   
               
               
                 1229 
                 3436 
                 CGACCCGGUGCCUGCCCGC 
                 4772 
                 GCGGGCAGGCACCGGGUCG 
                 50.8 
                 38.8 
               
               
                   
               
               
                 1230 
                 3437 
                 GACCCGGUGCCUGCCCGCA 
                 4773 
                 UGCGGGCAGGCACCGGGUC 
                 65.8 
                 53.8 
               
               
                   
               
               
                 1231 
                 3438 
                 ACCCGGUGCCUGCCCGCAA 
                 4774 
                 UUGCGGGCAGGCACCGGGU 
                 72.6 
                 60.6 
               
               
                   
               
               
                 1232 
                 3439 
                 CCCGGUGCCUGCCCGCAAC 
                 4775 
                 GUUGCGGGCAGGCACCGGG 
                 59.7 
                 47.7 
               
               
                   
               
               
                 1233 
                 3440 
                 CCGGUGCCUGCCCGCAACC 
                 4776 
                 GGUUGCGGGCAGGCACCGG 
                 49.5 
                 37.5 
               
               
                   
               
               
                 1234 
                 3441 
                 CGGUGCCUGCCCGCAACCG 
                 4777 
                 CGGUUGCGGGCAGGCACCG 
                 51.8 
                 39.8 
               
               
                   
               
               
                 1235 
                 3442 
                 GGUGCCUGCCCGCAACCGU 
                 4778 
                 ACGGUUGCGGGCAGGCACC 
                 65.8 
                 53.8 
               
               
                   
               
               
                 1236 
                 3443 
                 GUGCCUGCCCGCAACCGUC 
                 4779 
                 GACGGUUGCGGGCAGGCAC 
                 55.5 
                 43.5 
               
               
                   
               
               
                 1237 
                 3444 
                 UGCCUGCCCGCAACCGUCG 
                 4780 
                 CGACGGUUGCGGGCAGGCA 
                 45.8 
                 33.8 
               
               
                   
               
               
                 1238 
                 3445 
                 GCCUGCCCGCAACCGUCGA 
                 4781 
                 UCGACGGUUGCGGGCAGGC 
                 72.1 
                 60.1 
               
               
                   
               
               
                 1239 
                 3446 
                 CCUGCCCGCAACCGUCGAG 
                 4782 
                 CUCGACGGUUGCGGGCAGG 
                 54.6 
                 42.6 
               
               
                   
               
               
                 1240 
                 3447 
                 CUGCCCGCAACCGUCGAGC 
                 4783 
                 GCUCGACGGUUGCGGGCAG 
                 39.2 
                 27.2 
               
               
                   
               
               
                 1241 
                 3448 
                 UGCCCGCAACCGUCGAGCC 
                 4784 
                 GGCUCGACGGUUGCGGGCA 
                 43.2 
                 31.2 
               
               
                   
               
               
                 1242 
                 3449 
                 GCCCGCAACCGUCGAGCCC 
                 4785 
                 GGGCUCGACGGUUGCGGGC 
                 50.8 
                 38.8 
               
               
                   
               
               
                 1267 
                 3450 
                 CCCGGGAAGAGGCGGGCCG 
                 4786 
                 CGGCCCGCCUCUUCCCGGG 
                 48.2 
                 36.2 
               
               
                   
               
               
                 1268 
                 3451 
                 CCGGGAAGAGGCGGGCCGG 
                 4787 
                 CCGGCCCGCCUCUUCCCGG 
                 47.9 
                 35.9 
               
               
                   
               
               
                 1269 
                 3452 
                 CGGGAAGAGGCGGGCCGGC 
                 4788 
                 GCCGGCCCGCCUCUUCCCG 
                 43.6 
                 31.6 
               
               
                   
               
               
                 1270 
                 3453 
                 GGGAAGAGGCGGGCCGGCU 
                 4789 
                 AGCCGGCCCGCCUCUUCCC 
                 60.7 
                 48.7 
               
               
                   
               
               
                 1271 
                 3454 
                 GGAAGAGGCGGGCCGGCUG 
                 4790 
                 CAGCCGGCCCGCCUCUUCC 
                 63.9 
                 51.9 
               
               
                   
               
               
                 1272 
                 3455 
                 GAAGAGGCGGGCCGGCUGU 
                 4791 
                 ACAGCCGGCCCGCCUCUUC 
                 66.7 
                 54.7 
               
               
                   
               
               
                 1273 
                 3456 
                 AAGAGGCGGGCCGGCUGUG 
                 4792 
                 CACAGCCGGCCCGCCUCUU 
                 48.5 
                 36.5 
               
               
                   
               
               
                 1274 
                 3457 
                 AGAGGCGGGCCGGCUGUGG 
                 4793 
                 CCACAGCCGGCCCGCCUCU 
                 46 
                 34 
               
               
                   
               
               
                 1275 
                 3458 
                 GAGGCGGGCCGGCUGUGGU 
                 4794 
                 ACCACAGCCGGCCCGCCUC 
                 61.8 
                 49.8 
               
               
                   
               
               
                 1276 
                 3459 
                 AGGCGGGCCGGCUGUGGUC 
                 4795 
                 GACCACAGCCGGCCCGCCU 
                 53.6 
                 41.6 
               
               
                   
               
               
                 1277 
                 3460 
                 GGCGGGCCGGCUGUGGUCG 
                 4796 
                 CGACCACAGCCGGCCCGCC 
                 53.1 
                 41.1 
               
               
                   
               
               
                 1278 
                 3461 
                 GCGGGCCGGCUGUGGUCGA 
                 4797 
                 UCGACCACAGCCGGCCCGC 
                 74.2 
                 62.2 
               
               
                   
               
               
                 1279 
                 3462 
                 CGGGCCGGCUGUGGUCGAU 
                 4798 
                 AUCGACCACAGCCGGCCCG 
                 70.7 
                 58.7 
               
               
                   
               
               
                 1280 
                 3463 
                 GGGCCGGCUGUGGUCGAUG 
                 4799 
                 CAUCGACCACAGCCGGCCC 
                 52.7 
                 50.7 
               
               
                   
               
               
                 1281 
                 3464 
                 GGCCGGCUGUGGUCGAUGG 
                 4800 
                 CCAUCGACCACAGCCGGCC 
                 69.7 
                 57.7 
               
               
                   
               
               
                 1282 
                 3465 
                 GCCGGCUGUGGUCGAUGGU 
                 4801 
                 ACCAUCGACCACAGCCGGC 
                 72 
                 60 
               
               
                   
               
               
                 1283 
                 3466 
                 CCGGCUGUGGUCGAUGGUG 
                 4802 
                 CACCAUCGACCACAGCCGG 
                 64.9 
                 52.9 
               
               
                   
               
               
                 1284 
                 3467 
                 CGGCUGUGGUCGAUGGUGA 
                 4803 
                 UCACCAUCGACCACAGCCG 
                 88.4 
                 76.4 
               
               
                   
               
               
                 1285 
                 3468 
                 GGCUGUGGUCGAUGGUGAC 
                 4804 
                 GUCACCAUCGACCACAGCC 
                 78.1 
                 66.1 
               
               
                   
               
               
                 1286 
                 3469 
                 GCUGUGGUCGAUGGUGACC 
                 4805 
                 GGUCACCAUCGACCACAGC 
                 63.9 
                 51.9 
               
               
                   
               
               
                 1287 
                 3470 
                 CUGUGGUCGAUGGUGACCG 
                 4806 
                 CGGUCACCAUCGACCACAG 
                 58 
                 46 
               
               
                   
               
               
                 1288 
                 3471 
                 UGUGGUCGAUGGUGACCGA 
                 4807 
                 UCGGUCACCAUCGACCACA 
                 84.6 
                 72.6 
               
               
                   
               
               
                 1289 
                 3472 
                 GUGGUCGAUGGUGACCGAG 
                 4808 
                 CUCGGUCACCAUCGACCAC 
                 64.7 
                 52.7 
               
               
                   
               
               
                 1290 
                 3473 
                 UGGUCGAUGGUGACCGAGG 
                 4809 
                 CCUCGGUCACCAUCGACCA 
                 60.6 
                 48.6 
               
               
                   
               
               
                 1291 
                 3474 
                 GGUCGAUGGUGACCGAGGA 
                 4810 
                 UCCUCGGUCACCAUCGACC 
                 92.2 
                 80.2 
               
               
                   
               
               
                 1292 
                 3475 
                 GUCGAUGGUGACCGAGGAG 
                 4811 
                 CUCCUCGGUCACCAUCGAC 
                 69.3 
                 57.3 
               
               
                   
               
               
                 1293 
                 3476 
                 UCGAUGGUGACCGAGGAGG 
                 4812 
                 CCUCCUCGGUCACCAUCGA 
                 49.8 
                 37.8 
               
               
                   
               
               
                 1294 
                 3477 
                 CGAUGGUGACCGAGGAGGA 
                 4813 
                 UCCUCCUCGGUCACCAUCG 
                 88.4 
                 76.4 
               
               
                   
               
               
                 1295 
                 3478 
                 GAUGGUGACCGAGGAGGAG 
                 4814 
                 CUCCUCCUCGGUCACCAUC 
                 69 
                 57 
               
               
                   
               
               
                 1296 
                 3479 
                 AUGGUGACCGAGGAGGAGC 
                 4815 
                 GCUCCUCCUCGGUCACCAU 
                 46.7 
                 34.7 
               
               
                   
               
               
                 1297 
                 3480 
                 UGGUGACCGAGGAGGAGCG 
                 4816 
                 CGCUCCUCCUCGGUCACCA 
                 55.8 
                 43.8 
               
               
                   
               
               
                 1298 
                 3481 
                 GGUGACCGAGGAGGAGCGG 
                 4817 
                 CCGCUCCUCCUCGGUCACC 
                 60.9 
                 48.9 
               
               
                   
               
               
                 1299 
                 3482 
                 GUGACCGAGGAGGAGCGGC 
                 4818 
                 GCCGCUCCUCCUCGGUCAC 
                 47.3 
                 35.3 
               
               
                   
               
               
                 1300 
                 3483 
                 UGACCGAGGAGGAGCGGCC 
                 4819 
                 GGCCGCUCCUCCUCGGUCA 
                 46.7 
                 33.7 
               
               
                   
               
               
                 1301 
                 3484 
                 GACCGAGGAGGAGCGGCCC 
                 4820 
                 GGGCCGCUCCUCCUCGGUC 
                 53.4 
                 40.4 
               
               
                   
               
               
                 1302 
                 3485 
                 ACCGAGGAGGAGCGGCCCA 
                 4821 
                 UGGGCCGCUCCUCCUCGGU 
                 67.1 
                 54.1 
               
               
                   
               
               
                 1303 
                 3486 
                 CCGAGGAGGAGCGGCCCAC 
                 4822 
                 GUGGGCCGCUCCUCCUCGG 
                 55.3 
                 42.3 
               
               
                   
               
               
                 1304 
                 3487 
                 CGAGGAGGAGCGGCCCACG 
                 4823 
                 CGUGGGCCGCUCCUCCUCG 
                 57.6 
                 44.6 
               
               
                   
               
               
                 1305 
                 3488 
                 GAGGAGGAGCGGCCCACGA 
                 4824 
                 UCGUGGGCCGCUCCUCCUC 
                 76.3 
                 63.3 
               
               
                   
               
               
                 1306 
                 3489 
                 AGGAGGAGCGGCCCACGAC 
                 4825 
                 GUCGUGGGCCGCUCCUCCU 
                 59 
                 46 
               
               
                   
               
               
                 1307 
                 3490 
                 GGAGGAGCGGCCCACGACG 
                 4826 
                 CGUCGUGGGCCGCUCCUCC 
                 64.5 
                 51.5 
               
               
                   
               
               
                 1308 
                 3491 
                 GAGGAGCGGCCCACGACGG 
                 4827 
                 CCGUCGUGGGCCGCUCCUC 
                 59.4 
                 46.4 
               
               
                   
               
               
                 1309 
                 3492 
                 AGGAGCGGCCCACGACGGC 
                 4828 
                 GCCGUCGUGGGCCGCUCCU 
                 47.1 
                 34.1 
               
               
                   
               
               
                 1310 
                 3493 
                 GGAGCGGCCCACGACGGCC 
                 4829 
                 GGCCGUCGUGGGCCGCUCC 
                 52.1 
                 39.1 
               
               
                   
               
               
                 1311 
                 3494 
                 GAGCGGCCCACGACGGCCG 
                 4830 
                 CGGCCGUCGUGGGCCGCUC 
                 54.8 
                 41.8 
               
               
                   
               
               
                 1312 
                 3495 
                 AGCGGCCCACGACGGCCGC 
                 4831 
                 GCGGCCGUCGUGGGCCGCU 
                 45 
                 32 
               
               
                   
               
               
                 1313 
                 3496 
                 GCGGCCCACGACGGCCGCA 
                 4832 
                 UGCGGCCGUCGUGGGCCGC 
                 63.7 
                 50.7 
               
               
                   
               
               
                 1314 
                 3497 
                 CGGCCCACGACGGCCGCAG 
                 4833 
                 CUGCGGCCGUCGUGGGCCG 
                 53.2 
                 40.2 
               
               
                   
               
               
                 1315 
                 3498 
                 GGCCCACGACGGCCGCAGG 
                 4834 
                 CCUGCGGCCGUCGUGGGCC 
                 58 
                 45 
               
               
                   
               
               
                 1316 
                 3499 
                 GCCCACGACGGCCGCAGGC 
                 4835 
                 GCCUGCGGCCGUCGUGGGC 
                 47.6 
                 34.6 
               
               
                   
               
               
                 1317 
                 3500 
                 CCCACGACGGCCGCAGGCA 
                 4836 
                 UGCCUGCGGCCGUCGUGGG 
                 66.5 
                 53.5 
               
               
                   
               
               
                 1318 
                 3501 
                 CCACGACGGCCGCAGGCAC 
                 4837 
                 GUGCCUGCGGCCGUCGUGG 
                 61.6 
                 48.6 
               
               
                   
               
               
                 1319 
                 3502 
                 CACGACGGCCGCAGGCACC 
                 4838 
                 GGUGCCUGCGGCCGUCGUG 
                 52.3 
                 39.3 
               
               
                   
               
               
                 1320 
                 3503 
                 ACGACGGCCGCAGGCACCA 
                 4839 
                 UGGUGCCUGCGGCCGUCGU 
                 65 
                 52 
               
               
                   
               
               
                 1321 
                 3504 
                 CGACGGCCGCAGGCACCAA 
                 4840 
                 UUGGUGCCUGCGGCCGUCG 
                 82.7 
                 69.7 
               
               
                   
               
               
                 1322 
                 3505 
                 GACGGCCGCAGGCACCAAC 
                 4841 
                 GUUGGUGCCUGCGGCCGUC 
                 57 
                 44 
               
               
                   
               
               
                 1323 
                 3506 
                 ACGGCCGCAGGCACCAACC 
                 4842 
                 GGUUGGUGCCUGCGGCCGU 
                 45.2 
                 32.2 
               
               
                   
               
               
                 1324 
                 3507 
                 CGGCCGCAGGCACCAACCU 
                 4843 
                 AGGUUGGUGCCUGCGGCCG 
                 66.8 
                 53.8 
               
               
                   
               
               
                 1325 
                 3508 
                 GGCCGCAGGCACCAACCUG 
                 4844 
                 CAGGUUGGUGCCUGCGGCC 
                 63.5 
                 50.5 
               
               
                   
               
               
                 1326 
                 3509 
                 GCCGCAGGCACCAACCUGC 
                 4845 
                 GCAGGUUGGUGCCUGCGGC 
                 56.5 
                 43.5 
               
               
                   
               
               
                 1327 
                 3510 
                 CCGCAGGCACCAACCUGCA 
                 4846 
                 UGCAGGUUGGUGCCUGCGG 
                 77.1 
                 64.1 
               
               
                   
               
               
                 1328 
                 3511 
                 CGCAGGCACCAACCUGCAC 
                 4847 
                 GUGCAGGUUGGUGCCUGCG 
                 65.9 
                 52.9 
               
               
                   
               
               
                 1329 
                 3512 
                 GCAGGCACCAACCUGCACC 
                 4848 
                 GGUGCAGGUUGGUGCCUGC 
                 55.6 
                 42.6 
               
               
                   
               
               
                 1330 
                 3513 
                 CAGGCACCAACCUGCACCG 
                 4849 
                 CGGUGCAGGUUGGUGCCUG 
                 58.3 
                 45.3 
               
               
                   
               
               
                 1331 
                 3514 
                 AGGCACCAACCUGCACCGG 
                 4850 
                 CCGGUGCAGGUUGGUGCCU 
                 50.4 
                 37.4 
               
               
                   
               
               
                 1332 
                 3515 
                 GGCACCAACCUGCACCGGC 
                 4851 
                 GCCGGUGCAGGUUGGUGCC 
                 54.5 
                 41.5 
               
               
                   
               
               
                 1333 
                 3516 
                 GCACCAACCUGCACCGGCU 
                 4852 
                 AGCCGGUGCAGGUUGGUGC 
                 75.5 
                 62.5 
               
               
                   
               
               
                 1334 
                 3517 
                 CACCAACCUGCACCGGCUG 
                 4853 
                 CAGCCGGUGCAGGUUGGUG 
                 63.2 
                 50.2 
               
               
                   
               
               
                 1335 
                 3518 
                 ACCAACCUGCACCGGCUGG 
                 4854 
                 CCAGCCGGUGCAGGUUGGU 
                 50.1 
                 37.1 
               
               
                   
               
               
                 1336 
                 3519 
                 CCAACCUGCACCGGCUGGU 
                 4855 
                 ACCAGCCGGUGCAGGUUGG 
                 59.4 
                 46.4 
               
               
                   
               
               
                 1337 
                 3520 
                 CAACCUGCACCGGCUGGUG 
                 4856 
                 CACCAGCCGGUGCAGGUUG 
                 60.6 
                 47.6 
               
               
                   
               
               
                 1338 
                 3521 
                 AACCUGCACCGGCUGGUGU 
                 4857 
                 ACACCAGCCGGUGCAGGUU 
                 62.4 
                 49.4 
               
               
                   
               
               
                 1339 
                 3522 
                 ACCUGCACCGGCUGGUGUG 
                 4858 
                 CACACCAGCCGGUGCAGGU 
                 60.1 
                 47.1 
               
               
                   
               
               
                 1340 
                 3523 
                 CCUGCACCGGCUGGUGUGG 
                 4859 
                 CCACACCAGCCGGUGCAGG 
                 57.3 
                 44.3 
               
               
                   
               
               
                 1341 
                 3524 
                 CUGCACCGGCUGGUGUGGG 
                 4860 
                 CCCACACCAGCCGGUGCAG 
                 44.7 
                 31.7 
               
               
                   
               
               
                 1342 
                 3525 
                 UGCACCGGCUGGUGUGGGA 
                 4861 
                 UCCCACACCAGCCGGUGCA 
                 67 
                 54 
               
               
                   
               
               
                 1343 
                 3526 
                 GCACCGGCUGGUGUGGGAG 
                 4862 
                 CUCCCACACCAGCCGGUGC 
                 61.3 
                 48.3 
               
               
                   
               
               
                 1344 
                 3527 
                 CACCGGCUGGUGUGGGAGC 
                 4863 
                 GCUCCCACACCAGCCGGUG 
                 54.1 
                 41.1 
               
               
                   
               
               
                 1345 
                 3528 
                 ACCGGCUGGUGUGGGAGCU 
                 4864 
                 AGCUCCCACACCAGCCGGU 
                 59.3 
                 46.3 
               
               
                   
               
               
                 1346 
                 3529 
                 CCGGCUGGUGUGGGAGCUC 
                 4865 
                 GAGCUCCCACACCAGCCGG 
                 58 
                 45 
               
               
                   
               
               
                 1347 
                 3530 
                 CGGCUGGUGUGGGAGCUCC 
                 4866 
                 GGAGCUCCCACACCAGCCG 
                 60.9 
                 47.9 
               
               
                   
               
               
                 1348 
                 3531 
                 GGCUGGUGUGGGAGCUCCG 
                 4867 
                 CGGAGCUCCCACACCAGCC 
                 69.2 
                 56.2 
               
               
                   
               
               
                 1349 
                 3532 
                 GCUGGUGUGGGAGCUCCGC 
                 4868 
                 GOGGAGCUCCCACACCAGC 
                 57.5 
                 44.5 
               
               
                   
               
               
                 1350 
                 3533 
                 CUGGUGUGGGAGCUCCGCG 
                 4869 
                 CGCGGAGCUCCCACACCAG 
                 51.8 
                 38.8 
               
               
                   
               
               
                 1351 
                 3534 
                 UGGUGUGGGAGCUCCGCGA 
                 4870 
                 UCGCGGAGCUCCCACACCA 
                 73.2 
                 60.2 
               
               
                   
               
               
                 1352 
                 3535 
                 GGUGUGGGAGCUCCGCGAG 
                 4871 
                 CUCGCGGAGCUCCCACACC 
                 70.5 
                 57.5 
               
               
                   
               
               
                 1353 
                 3536 
                 GUGUGGGAGCUCCGCGAGC 
                 4872 
                 GCUCGCGGAGCUCCCACAC 
                 57.9 
                 44.9 
               
               
                   
               
               
                 1354 
                 3537 
                 UGUGGGAGCUCCGCGAGCG 
                 4873 
                 CGCUCGCGGAGCUCCCACA 
                 52.9 
                 39.9 
               
               
                   
               
               
                 1355 
                 3538 
                 GUGGGAGCUCCGCGAGCGU 
                 4874 
                 ACGCUCGCGGAGCUCCCAC 
                 67.6 
                 54.6 
               
               
                   
               
               
                 1356 
                 3539 
                 UGGGAGCUCCGCGAGCGUC 
                 4875 
                 GACGCUCGCGGAGCUCCCA 
                 50.5 
                 37.5 
               
               
                   
               
               
                 1357 
                 3540 
                 GGGAGCUCCGCGAGCGUCU 
                 4876 
                 AGACGCUCGCGGAGCUCCC 
                 73 
                 60 
               
               
                   
               
               
                 1358 
                 3541 
                 GGAGCUCCGCGAGCGUCUG 
                 4877 
                 CAGACGCUCGCGGAGCUCC 
                 69.9 
                 56.9 
               
               
                   
               
               
                 1359 
                 3542 
                 GAGCUCCGCGAGCGUCUGG 
                 4878 
                 CCAGACGCUCGCGGAGCUC 
                 58.9 
                 45.9 
               
               
                   
               
               
                 1388 
                 3543 
                 GGGCUUCUGGGCCCGGCUG 
                 4879 
                 CAGCCGGGCCCAGAAGCCC 
                 58.5 
                 45.5 
               
               
                   
               
               
                 1389 
                 3544 
                 GGCUUCUGGGCCCGGCUGU 
                 4880 
                 ACAGCCGGGCCCAGAAGCC 
                 65.1 
                 52.1 
               
               
                   
               
               
                 1390 
                 3545 
                 GCUUCUGGGCCCGGCUGUC 
                 4881 
                 GACAGCCGGGCCCAGAAGC 
                 57 
                 44 
               
               
                   
               
               
                 1391 
                 3546 
                 CUUCUGGGCCCGGCUGUCC 
                 4882 
                 GGACAGCCGGGCCCAGAAG 
                 44.4 
                 31.4 
               
               
                   
               
               
                 1392 
                 3547 
                 UUCUGGGCCCGGCUGUCCC 
                 4883 
                 GGGACAGCCGGGCCCAGAA 
                 36.5 
                 23.5 
               
               
                   
               
               
                 1393 
                 3548 
                 UCUGGGCCCGGCUGUCCCU 
                 4884 
                 AGGGACAGCCGGGCCCAGA 
                 53.2 
                 40.2 
               
               
                   
               
               
                 1394 
                 3549 
                 CUGGGCCCGGCUGUCCCUG 
                 4885 
                 CAGGGACAGCCGGGCCCAG 
                 43.5 
                 30.5 
               
               
                   
               
               
                 1395 
                 3550 
                 UGGGCCCGGCUGUCCCUGA 
                 4886 
                 UCAGGGACAGCCGGGCCCA 
                 59 
                 46 
               
               
                   
               
               
                 1396 
                 3551 
                 GGGCCCGGCUGUCCCUGAC 
                 4887 
                 GUCAGGGACAGCCGGGCCC 
                 59.4 
                 46.4 
               
               
                   
               
               
                 1397 
                 3552 
                 GGCCCGGCUGUCCCUGACG 
                 4888 
                 CGUCAGGGACAGCCGGGCC 
                 58.9 
                 45.9 
               
               
                   
               
               
                 1398 
                 3553 
                 GCCCGGCUGUCCCUGACGG 
                 4889 
                 CCGUCAGGGACAGCCGGGC 
                 58.6 
                 45.6 
               
               
                   
               
               
                 1399 
                 3554 
                 CCCGGCUGUCCCUGACGGU 
                 4890 
                 ACCGUCAGGGACAGCCGGG 
                 64.7 
                 51.7 
               
               
                   
               
               
                 1400 
                 3555 
                 CCGGCUGUCCCUGACGGUG 
                 4891 
                 CACCGUCAGGGACAGCCGG 
                 60.9 
                 46.9 
               
               
                   
               
               
                 1401 
                 3556 
                 CGGCUGUCCCUGACGGUGU 
                 4892 
                 ACACCGUCAGGGACAGCCG 
                 76.4 
                 62.4 
               
               
                   
               
               
                 1402 
                 3557 
                 GGCUGUCCCUGACGGUGUG 
                 4893 
                 CACACCGUCAGGGACAGCC 
                 76.7 
                 62.7 
               
               
                   
               
               
                 1403 
                 3558 
                 GCUGUCCCUGACGGUGUGC 
                 4894 
                 GCACACCGUCAGGGACAGC 
                 57.6 
                 43.6 
               
               
                   
               
               
                 1404 
                 3559 
                 CUGUCCCUGACGGUGUGCG 
                 4895 
                 CGCACACCGUCAGGGACAG 
                 49.9 
                 35.9 
               
               
                   
               
               
                 1405 
                 3560 
                 UGUCCCUGACGGUGUGCGG 
                 4896 
                 CCGCACACCGUCAGGGACA 
                 56.2 
                 42.2 
               
               
                   
               
               
                 1406 
                 3561 
                 GUCCCUGACGGUGUGCGGA 
                 4897 
                 UCCGCACACCGUCAGGGAC 
                 72.1 
                 58.1 
               
               
                   
               
               
                 1407 
                 3562 
                 UCCCUGACGGUGUGCGGAG 
                 4898 
                 CUCCGCACACCGUCAGGGA 
                 56.2 
                 42.2 
               
               
                   
               
               
                 1408 
                 3563 
                 CCCUGACGGUGUGCGGAGA 
                 4899 
                 UCUCCGCACACCGUCAGGG 
                 80.8 
                 66.8 
               
               
                   
               
               
                 1409 
                 3564 
                 CCUGACGGUGUGCGGAGAC 
                 4900 
                 GUCUCCGCACACCGUCAGG 
                 63.8 
                 49.8 
               
               
                   
               
               
                 1410 
                 3565 
                 CUGACGGUGUGCGGAGACU 
                 4901 
                 AGUCUCCGCACACCGUCAG 
                 71.5 
                 57.8 
               
               
                   
               
               
                 1411 
                 3566 
                 UGACGGUGUGCGGAGACUC 
                 4902 
                 GAGUCUCCGCACACCGUCA 
                 61.6 
                 47.6 
               
               
                   
               
               
                 1412 
                 3567 
                 GACGGUGUGCGGAGACUCU 
                 4903 
                 AGAGUCUCCGCACACCGUC 
                 83.1 
                 69.1 
               
               
                   
               
               
                 1413 
                 3568 
                 ACGGUGUGCGGAGACUCUC 
                 4904 
                 GAGAGUCUCCGCACACCGU 
                 63.3 
                 49.3 
               
               
                   
               
               
                 1414 
                 3569 
                 CGGUGUGCGGAGACUCUCG 
                 4905 
                 CGAGAGUCUCCGCACACCG 
                 72.6 
                 58.6 
               
               
                   
               
               
                 1415 
                 3570 
                 GGUGUGCGGAGACUCUCGC 
                 4906 
                 GCGAGAGUCUCCGCACACC 
                 63.9 
                 49.9 
               
               
                   
               
               
                 1416 
                 3571 
                 GUGUGCGGAGACUCUCGCA 
                 4907 
                 UGCGAGAGUCUCCGCACAC 
                 78.1 
                 64.1 
               
               
                   
               
               
                 1417 
                 3572 
                 UGUGCGGAGACUCUCGCAU 
                 4908 
                 AUGCGAGAGUCUCCGCACA 
                 70.1 
                 56.1 
               
               
                   
               
               
                 1418 
                 3573 
                 GUGCGGAGACUCUCGCAUG 
                 4909 
                 CAUGCGAGAGUCUCCGCAC 
                 69.2 
                 55.2 
               
               
                   
               
               
                 1419 
                 3574 
                 UGCGGAGACUCUCGCAUGG 
                 4910 
                 CCAUGCGAGAGUCUCCGCA 
                 59.3 
                 45.3 
               
               
                   
               
               
                 1436 
                 3575 
                 GGCAGCGGACGCCUCGCUG 
                 4911 
                 CAGCGAGGCGUCCGCUGCC 
                 62.1 
                 48.1 
               
               
                   
               
               
                 1437 
                 3576 
                 GCAGCGGACGCCUCGCUGG 
                 4912 
                 CCAGCGAGGCGUCCGCUGC 
                 60.3 
                 46.3 
               
               
                   
               
               
                 1438 
                 3577 
                 CAGCGGACGCCUCGCUGGA 
                 4913 
                 UCCAGCGAGGCGUCCGCUG 
                 72.9 
                 58.9 
               
               
                   
               
               
                 1439 
                 3578 
                 AGCGGACGCCUCGCUGGAG 
                 4914 
                 CUCCAGCGAGGCGUCCGCU 
                 54.6 
                 40.6 
               
               
                   
               
               
                 1440 
                 3579 
                 GCGGACGCCUCGCUGGAGG 
                 4915 
                 CCUCCAGCGAGGCGUCCGC 
                 54.5 
                 40.5 
               
               
                   
               
               
                 1441 
                 3580 
                 CGGACGCCUCGCUGGAGGC 
                 4916 
                 GCCUCCAGCGAGGCGUCCG 
                 51.8 
                 37.8 
               
               
                   
               
               
                 1442 
                 3581 
                 GGACGCCUCGCUGGAGGCG 
                 4917 
                 CGCCUCCAGCGAGGCGUCC 
                 51 
                 37 
               
               
                   
               
               
                 1443 
                 3582 
                 GACGCCUCGCUGGAGGCGG 
                 4918 
                 CCGCCUCCAGCGAGGCGUC 
                 48 
                 34 
               
               
                   
               
               
                 1444 
                 3583 
                 ACGCCUCGCUGGAGGCGGC 
                 4919 
                 GCCGCCUCCAGCGAGGCGU 
                 45 
                 31 
               
               
                   
               
               
                 1445 
                 3584 
                 CGCCUCGCUGGAGGCGGCG 
                 4920 
                 CGCCGCCUCCAGCGAGGCG 
                 45.6 
                 31.6 
               
               
                   
               
               
                 1446 
                 3585 
                 GCCUCGCUGGAGGCGGCGC 
                 4921 
                 GCGCCGCCUCCAGCGAGGC 
                 46.8 
                 32.8 
               
               
                   
               
               
                 1447 
                 3586 
                 CCUCGCUGGAGGCGGCGCC 
                 4922 
                 GGCGCCGCCUCCAGCGAGG 
                 43.7 
                 29.7 
               
               
                   
               
               
                 1448 
                 3587 
                 CUCGCUGGAGGCGGCGCCC 
                 4923 
                 GGGCGCCGCCUCCAGCGAG 
                 40.3 
                 26.3 
               
               
                   
               
               
                 1449 
                 3588 
                 UCGCUGGAGGCGGCGCCCU 
                 4924 
                 AGGGCGCCGCCUCCAGCGA 
                 46.4 
                 32.4 
               
               
                   
               
               
                 1450 
                 3589 
                 CGCUGGAGGCGGCGCCCUG 
                 4925 
                 CAGGGCGCCGCCUCCAGCG 
                 61.1 
                 47.1 
               
               
                   
               
               
                 1451 
                 3590 
                 GCUGGAGGCGGCGCCCUGC 
                 4926 
                 GCAGGGCGCCGCCUCCAGC 
                 51.4 
                 37.4 
               
               
                   
               
               
                 1452 
                 3591 
                 CUGGAGGCGGCGCCCUGCU 
                 4927 
                 AGCAGGGCGCCGCCUCCAG 
                 57.2 
                 43.2 
               
               
                   
               
               
                 1453 
                 3592 
                 UGGAGGCGGCGCCCUGCUG 
                 4928 
                 CAGCAGGGCGCCGCCUCCA 
                 51.8 
                 37.8 
               
               
                   
               
               
                 1454 
                 3593 
                 GGAGGCGGCGCCCUGCUGG 
                 4929 
                 CCAGCAGGGCGCCGCCUCC 
                 53.9 
                 39.9 
               
               
                   
               
               
                 1455 
                 3594 
                 GAGGCGGCGCCCUGCUGGA 
                 4930 
                 UCCAGCAGGGCGCCGCCUC 
                 70.9 
                 56.9 
               
               
                   
               
               
                 1456 
                 3595 
                 AGGCGGCGCCCUGCUGGAC 
                 4931 
                 GUCCAGCAGGGCGCCGCCU 
                 50.3 
                 36.3 
               
               
                   
               
               
                 1457 
                 3596 
                 GGCGGCGCCCUGCUGGACC 
                 4932 
                 GGUCCAGCAGGGCGCCGCC 
                 51 
                 37 
               
               
                   
               
               
                 1458 
                 3597 
                 GCGGCGCCCUGCUGGACCG 
                 4933 
                 CGGUCCAGCAGGGCGCCGC 
                 60.4 
                 46.4 
               
               
                   
               
               
                 1459 
                 3598 
                 CGGCGCCCUGCUGGACCGG 
                 4934 
                 CCGGUCCAGCAGGGCGCCG 
                 49.7 
                 35.7 
               
               
                   
               
               
                 1460 
                 3599 
                 GGCGCCCUGCUGGACCGGA 
                 4935 
                 UCCGGUCCAGCAGGGCGCC 
                 67.2 
                 53.2 
               
               
                   
               
               
                 1461 
                 3600 
                 GCGCCCUGCUGGACCGGAG 
                 4936 
                 CUCCGGUCCAGCAGGGCGC 
                 63.8 
                 49.8 
               
               
                   
               
               
                 1462 
                 3601 
                 CGCCCUGCUGGACCGGAGC 
                 4937 
                 GCUCCGGUCCAGCAGGGCG 
                 55.2 
                 41.2 
               
               
                   
               
               
                 1463 
                 3602 
                 GCCCUGCUGGACCGGAGCC 
                 4938 
                 GGCUCCGGUCCAGCAGGGC 
                 51.1 
                 37.1 
               
               
                   
               
               
                 1464 
                 3603 
                 CCCUGCUGGACCGGAGCCG 
                 4939 
                 CGGCUCCGGUCCAGCAGGG 
                 49.5 
                 35.5 
               
               
                   
               
               
                 1465 
                 3604 
                 CCUGCUGGACCGGAGCCGG 
                 4940 
                 CCGGCUCCGGUCCAGCAGG 
                 54.3 
                 40.3 
               
               
                   
               
               
                 1466 
                 3605 
                 CUGCUGGACCGGAGCCGGG 
                 4941 
                 CCCGGCUCCGGUCCAGCAG 
                 50 
                 36 
               
               
                   
               
               
                 1467 
                 3606 
                 UGCUGGACCGGAGCCGGGC 
                 4942 
                 GCCCGGCUCCGGUCCAGCA 
                 40.2 
                 26.2 
               
               
                   
               
               
                 1468 
                 3607 
                 GCUGGACCGGAGCCGGGCG 
                 4943 
                 CGCCCGGCUCCGGUCCAGC 
                 54.4 
                 40.4 
               
               
                   
               
               
                 1469 
                 3608 
                 CUGGACCGGAGCCGGGCGG 
                 4944 
                 CCGCCCGGCUCCGGUCCAG 
                 42.5 
                 28.5 
               
               
                   
               
               
                 1470 
                 3609 
                 UGGACCGGAGCCGGGCGGG 
                 4945 
                 CCCGCCCGGCUCCGGUCCA 
                 33.5 
                 19.5 
               
               
                   
               
               
                 1520 
                 3610 
                 CCCGGCCGAGCAGGUCAAC 
                 4946 
                 GUUGACCUGCUCGGCCGGG 
                 55.8 
                 40.8 
               
               
                   
               
               
                 1521 
                 3611 
                 CCGGCCGAGCAGGUCAACA 
                 4947 
                 UGUUGACCUGCUCGGCCGG 
                 70.4 
                 55.4 
               
               
                   
               
               
                 1522 
                 3612 
                 CGGCCGAGCAGGUCAACAA 
                 4948 
                 UUGUUGACCUGCUCGGCCG 
                 90.5 
                 75.5 
               
               
                   
               
               
                 1523 
                 3613 
                 GGCCGAGCAGGUCAACAAC 
                 4949 
                 GUUGUUGACCUGCUCGGCC 
                 74.6 
                 59.6 
               
               
                   
               
               
                 1524 
                 3614 
                 GCCGAGCAGGUCAACAACC 
                 4950 
                 GGUUGUUGACCUGCUCGGC 
                 64.6 
                 49.6 
               
               
                   
               
               
                 1525 
                 3615 
                 CCGAGCAGGUCAACAACCC 
                 4951 
                 GGGUUGUUGACCUGCUCGG 
                 63.2 
                 48.2 
               
               
                   
               
               
                 1542 
                 3616 
                 CCCGAGCUCAAGGUGGACG 
                 4952 
                 CGUCCACCUUGAGCUCGGG 
                 58.3 
                 43.3 
               
               
                   
               
               
                 1543 
                 3617 
                 CCGAGCUCAAGGUGGACGC 
                 4953 
                 GCGUCCACCUUGAGCUCGG 
                 59.7 
                 44.7 
               
               
                   
               
               
                 1544 
                 3618 
                 CGAGCUCAAGGUGGACGCC 
                 4954 
                 GGCGUCCACCUUGAGCUCG 
                 59.8 
                 44.8 
               
               
                   
               
               
                 1545 
                 3619 
                 GAGCUCAAGGUGGACGCCU 
                 4955 
                 AGGCGUCCACCUUGAGCUC 
                 66 
                 51 
               
               
                   
               
               
                 1546 
                 3620 
                 AGCUCAAGGUGGACGCCUC 
                 4956 
                 GAGGCGUCCACCUUGAGCU 
                 67.3 
                 52.3 
               
               
                   
               
               
                 1547 
                 3621 
                 GCUCAAGGUGGACGCCUCG 
                 4957 
                 CGAGGCGUCCACCUUGAGC 
                 66.4 
                 51.4 
               
               
                   
               
               
                 1548 
                 3622 
                 CUCAAGGUGGACGCCUCGG 
                 4958 
                 CCGAGGCGUCCACCUUGAG 
                 51.9 
                 36.9 
               
               
                   
               
               
                 1549 
                 3623 
                 UCAAGGUGGACGCCUCGGG 
                 4959 
                 CCCGAGGCGUCCACCUUGA 
                 44.5 
                 29.5 
               
               
                   
               
               
                 1550 
                 3624 
                 CAAGGUGGACGCCUCGGGC 
                 4960 
                 GCCCGAGGCGUCCACCUUG 
                 50.3 
                 35.3 
               
               
                   
               
               
                 1551 
                 3625 
                 AAGGUGGACGCCUCGGGCC 
                 4961 
                 GGCCCGAGGCGUCCACCUU 
                 39.8 
                 24.8 
               
               
                   
               
               
                 1552 
                 3626 
                 AGGUGGACGCCUCGGGCCC 
                 4962 
                 GGGCCCGAGGCGUCCACCU 
                 45.5 
                 30.5 
               
               
                   
               
               
                 1569 
                 3627 
                 CCCGAUGUCCCGACACGGC 
                 4963 
                 GCCGUGUCGGGACAUCGGG 
                 61.1 
                 46.1 
               
               
                   
               
               
                 1570 
                 3628 
                 CCGAUGUCCCGACACGGCG 
                 4964 
                 CGCCGUGUCGGGACAUCGG 
                 65.6 
                 50.6 
               
               
                   
               
               
                 1571 
                 3629 
                 CGAUGUCCCGACACGGCGG 
                 4965 
                 CCGCCGUGUCGGGACAUCG 
                 70.7 
                 55.7 
               
               
                   
               
               
                 1572 
                 3630 
                 GAUGUCCCGACACGGCGGC 
                 4966 
                 GCCGCCGUGUCGGGACAUC 
                 53.3 
                 38.3 
               
               
                   
               
               
                 1573 
                 3831 
                 AUGUCCCGACACGGCGGCG 
                 4987 
                 CGCCGCCGUGUCGGGACAU 
                 44.7 
                 29.7 
               
               
                   
               
               
                 1574 
                 3632 
                 UGUCCCGACACGGCGGCGU 
                 4968 
                 ACGCCGCCGUGUCGGGACA 
                 54.4 
                 39.4 
               
               
                   
               
               
                 1575 
                 3833 
                 GUCCCGACACGGCGGCGUC 
                 4969 
                 GACGCCGCCGUGUCGGGAC 
                 59.9 
                 44.9 
               
               
                   
               
               
                 1576 
                 3634 
                 UCCCGACACGGCGGCGUCG 
                 4970 
                 CGACGCCGCCGUGUCGGGA 
                 47.2 
                 32.2 
               
               
                   
               
               
                 1577 
                 3635 
                 CCCGACACGGCGGCGUCGG 
                 4971 
                 CCGACGCCGCCGUGUCGGG 
                 50.6 
                 35.6 
               
               
                   
               
               
                 1578 
                 3636 
                 CCGACACGGCGGCGUCGGC 
                 4972 
                 GCCGACGCCGCCGUGUCGG 
                 52.6 
                 37.6 
               
               
                   
               
               
                 1579 
                 3637 
                 CGACACGGCGGCGUCGGCU 
                 4973 
                 AGCCGACGCCGCCGUGUCG 
                 62.6 
                 47.6 
               
               
                   
               
               
                 1580 
                 3638 
                 GACACGGCGGCGUCGGCUA 
                 4974 
                 UAGCCGACGCCGCCGUGUC 
                 81.9 
                 66.9 
               
               
                   
               
               
                 1581 
                 3639 
                 ACACGGCGGCGUCGGCUAC 
                 4975 
                 GUAGCCGACGCCGCCGUGU 
                 59.6 
                 44.6 
               
               
                   
               
               
                 1582 
                 3640 
                 CACGGCGGCGUCGGCUACA 
                 4976 
                 UGUAGCCGACGCCGCCGUG 
                 69.5 
                 54.5 
               
               
                   
               
               
                 1583 
                 3641 
                 ACGGCGGCGUCGGCUACAG 
                 4977 
                 CUGUAGCCGACGCCGCCGU 
                 58.7 
                 43.7 
               
               
                   
               
               
                 1584 
                 3642 
                 CGGCGGCGUCGGCUACAGC 
                 4978 
                 GCUGUAGCCGACGCCGCCG 
                 59 
                 44 
               
               
                   
               
               
                 1585 
                 3643 
                 GGCGGCGUCGGCUACAGCU 
                 4979 
                 AGCUGUAGCCGACGCCGCC 
                 72.2 
                 57.2 
               
               
                   
               
               
                 1586 
                 3644 
                 GCGGCGUCGGCUACAGCUC 
                 4980 
                 GAGCUGUAGCCGACGCCGC 
                 68.1 
                 53.1 
               
               
                   
               
               
                 1587 
                 3645 
                 CGGCGUCGGCUACAGCUCC 
                 4981 
                 GGAGCUGUAGCCGACGCCG 
                 63.5 
                 48.5 
               
               
                   
               
               
                 1588 
                 3646 
                 GGCGUCGGCUACAGCUCCG 
                 4982 
                 CGGAGCUGUAGCCGACGCC 
                 66.2 
                 51.2 
               
               
                   
               
               
                 1589 
                 3647 
                 GCGUCGGCUACAGCUCCGG 
                 4983 
                 CCGGAGCUGUAGCCGACGC 
                 59.9 
                 44.9 
               
               
                   
               
               
                 1590 
                 3648 
                 CGUCGGCUACAGCUCCGGG 
                 4984 
                 CCCGGAGCUGUAGCCGACG 
                 59.1 
                 44.1 
               
               
                   
               
               
                 1591 
                 3649 
                 GUCGGCUACAGCUCCGGGC 
                 4985 
                 GCCCGGAGCUGUAGCCGAC 
                 49.4 
                 34.4 
               
               
                   
               
               
                 1592 
                 3650 
                 UCGGCUACAGCUCCGGGCG 
                 4986 
                 CGCCCGGAGCUGUAGCCGA 
                 47.4 
                 32.4 
               
               
                   
               
               
                 1593 
                 3651 
                 CGGCUACAGCUCCGGGCGG 
                 4987 
                 CCGCCCGGAGCUGUAGCCG 
                 59.9 
                 44.9 
               
               
                   
               
               
                 1594 
                 3652 
                 GGCUACAGCUCCGGGCGGC 
                 4988 
                 GCCGCCCGGAGCUGUAGCC 
                 53.9 
                 38.9 
               
               
                   
               
               
                 1595 
                 3653 
                 GCUACAGCUCCGGGCGGCC 
                 4989 
                 GGCCGCCCGGAGCUGUAGC 
                 51.1 
                 36.1 
               
               
                   
               
               
                 1627 
                 3654 
                 AAACGGCCGCACUGGGACA 
                 4990 
                 UGUCCCAGUGCGGCCGUUU 
                 65.7 
                 49.7 
               
               
                   
               
               
                 1628 
                 3655 
                 AACGGCCGCACUGGGACAC 
                 4991 
                 GUGUCCCAGUGCGGCCGUU 
                 42.2 
                 26.2 
               
               
                   
               
               
                 1629 
                 3656 
                 ACGGCCGCACUGGGACACG 
                 4992 
                 CGUGUCCCAGUGCGGCCGU 
                 43.4 
                 27.4 
               
               
                   
               
               
                 1630 
                 3657 
                 CGGCCGCACUGGGACACGA 
                 4993 
                 UCGUGUCCCAGUGCGGCCG 
                 76.3 
                 60.3 
               
               
                   
               
               
                 1631 
                 3658 
                 GGCCGCACUGGGACACGAC 
                 4994 
                 GUCGUGUCCCAGUGCGGCC 
                 64.2 
                 48.2 
               
               
                   
               
               
                 1632 
                 3659 
                 GCCGCACUGGGACACGACC 
                 4995 
                 GGUCGUGUCCCAGUGCGGC 
                 59.2 
                 43.2 
               
               
                   
               
               
                 1633 
                 3660 
                 CCGCACUGGGACACGACCU 
                 4996 
                 AGGUCGUGUCCCAGUGCGG 
                 69.2 
                 53.2 
               
               
                   
               
               
                 1634 
                 3661 
                 CGCACUGGGACACGACCUG 
                 4997 
                 CAGGUCGUGUCCCAGUGCG 
                 67.7 
                 51.7 
               
               
                   
               
               
                 1635 
                 3662 
                 GCACUGGGACACGACCUGG 
                 4998 
                 CCAGGUCGUGUCCCAGUGC 
                 64 
                 48 
               
               
                   
               
               
                 1636 
                 3663 
                 CACUGGGACACGACCUGGA 
                 4999 
                 UCCAGGUCGUGUCCCAGUG 
                 78.7 
                 62.7 
               
               
                   
               
               
                 1637 
                 3664 
                 ACUGGGACACGACCUGGAC 
                 5000 
                 GUCCAGGUCGUGUCCCAGU 
                 62.5 
                 46.5 
               
               
                   
               
               
                 1638 
                 3665 
                 CUGGGACACGACCUGGACG 
                 5001 
                 CGUCCAGGUCGUGUCCCAG 
                 57.9 
                 41.9 
               
               
                   
               
               
                 1639 
                 3666 
                 UGGGACACGACCUGGACGG 
                 5002 
                 CCGUCCAGGUCGUGUCCCA 
                 51.3 
                 35.3 
               
               
                   
               
               
                 1640 
                 3667 
                 GGGACACGACCUGGACGGG 
                 5003 
                 CCCGUCCAGGUCGUGUCCC 
                 59.6 
                 43.6 
               
               
                   
               
               
                 1641 
                 3668 
                 GGACACGACCUGGACGGGC 
                 5004 
                 GCCCGUCCAGGUCGUGUCC 
                 55.3 
                 39.3 
               
               
                   
               
               
                 1642 
                 3669 
                 GACACGACCUGGACGGGCA 
                 5005 
                 UGCCCGUCCAGGUCGUGUC 
                 82 
                 66 
               
               
                   
               
               
                 1643 
                 3670 
                 ACACGACCUGGACGGGCAG 
                 5006 
                 CUGCCCGUCCAGGUCGUGU 
                 63.6 
                 47.6 
               
               
                   
               
               
                 1644 
                 3671 
                 CACGACCUGGACGGGCAGG 
                 5007 
                 CCUGCCCGUCCAGGUCGUG 
                 51.2 
                 35.2 
               
               
                   
               
               
                 1645 
                 3672 
                 ACGACCUGGACGGGCAGGA 
                 5008 
                 UCCUGCCCGUCCAGGUCGU 
                 61.7 
                 45.7 
               
               
                   
               
               
                 1646 
                 3673 
                 CGACCUGGACGGGCAGGAC 
                 5009 
                 GUCCUGCCCGUCCAGGUCG 
                 63.9 
                 47.9 
               
               
                   
               
               
                 1647 
                 3674 
                 GACCUGGACGGGCAGGACG 
                 5010 
                 CGUCCUGCCCGUCCAGGUC 
                 60.6 
                 44.6 
               
               
                   
               
               
                 1648 
                 3675 
                 ACCUGGACGGGCAGGACGC 
                 5011 
                 GCGUCCUGCCCGUCCAGGU 
                 50.8 
                 34.8 
               
               
                   
               
               
                 1649 
                 3676 
                 CCUGGACGGGCAGGACGCG 
                 5012 
                 CGCGUCCUGCCCGUCCAGG 
                 52.2 
                 36.2 
               
               
                   
               
               
                 1650 
                 3677 
                 CUGGACGGGCAGGACGCGG 
                 5013 
                 CCGCGUCCUGCCCGUCCAG 
                 45.9 
                 29.9 
               
               
                   
               
               
                 1651 
                 3678 
                 UGGACGGGCAGGACGCGGA 
                 5014 
                 UCCGCGUCCUGCCCGUCCA 
                 65 
                 49 
               
               
                   
               
               
                 1652 
                 3679 
                 GGACGGGCAGGACGCGGAU 
                 5015 
                 AUCCGCGUCCUGCCCGUCC 
                 79.4 
                 63.4 
               
               
                   
               
               
                 1653 
                 3680 
                 GACGGGCAGGACGCGGAUG 
                 5016 
                 CAUCCGCGUCCUGCCCGUC 
                 61.6 
                 45.6 
               
               
                   
               
               
                 1654 
                 3681 
                 ACGGGCAGGACGCGGAUGA 
                 5017 
                 UCAUCCGCGUCCUGCCCGU 
                 66.8 
                 50.8 
               
               
                   
               
               
                 1655 
                 3682 
                 CGGGCAGGACGCGGAUGAG 
                 5018 
                 CUCAUCCGCGUCCUGCCCG 
                 64.4 
                 48.4 
               
               
                   
               
               
                 1656 
                 3683 
                 GGGCAGGACGCGGAUGAGG 
                 5019 
                 CCUCAUCCGCGUCCUGCCC 
                 59 
                 43 
               
               
                   
               
               
                 1657 
                 3684 
                 GGCAGGACGCGGAUGAGGA 
                 5020 
                 UCCUCAUCCGCGUCCUGCC 
                 81.1 
                 65.1 
               
               
                   
               
               
                 1658 
                 3685 
                 GCAGGACGCGGAUGAGGAU 
                 5021 
                 AUCCUCAUCCGCGUCCUGC 
                 82.1 
                 66.1 
               
               
                   
               
               
                 1659 
                 3686 
                 CAGGACGCGGAUGAGGAUG 
                 5022 
                 CAUCCUCAUCCGCGUCCUG 
                 60.9 
                 44.9 
               
               
                   
               
               
                 1660 
                 3687 
                 AGGACGCGGAUGAGGAUGC 
                 5023 
                 GCAUCCUCAUCCGCGUCCU 
                 56.2 
                 40.2 
               
               
                   
               
               
                 1661 
                 3688 
                 GGACGCGGAUGAGGAUGCC 
                 5024 
                 GGCAUCCUCAUCCGCGUCC 
                 60.4 
                 44.4 
               
               
                   
               
               
                 1694 
                 3689 
                 GGGACAGCAGUAUGCAGAU 
                 5025 
                 AUCUGCAUACUGCUGUCCC 
                 86.9 
                 70.9 
               
               
                   
               
               
                 1695 
                 3690 
                 GGACAGCAGUAUGCAGAUG 
                 5026 
                 CAUCUGCAUACUGCUGUCC 
                 79.5 
                 63.5 
               
               
                   
               
               
                 1696 
                 3691 
                 GACAGCAGUAUGCAGAUGA 
                 5027 
                 UCAUCUGCAUACUGCUGUC 
                 85.6 
                 69.6 
               
               
                   
               
               
                 1697 
                 3692 
                 ACAGCAGUAUGCAGAUGAC 
                 5028 
                 GUCAUCUGCAUACUGCUGU 
                 73.3 
                 57.3 
               
               
                   
               
               
                 1698 
                 3693 
                 CAGCAGUAUGCAGAUGACU 
                 5029 
                 AGUCAUCUGCAUACUGCUG 
                 77.2 
                 61.2 
               
               
                   
               
               
                 1699 
                 3694 
                 AGCAGUAUGCAGAUGACUG 
                 5030 
                 CAGUCAUCUGCAUACUGCU 
                 72.7 
                 56.7 
               
               
                   
               
               
                 1700 
                 3695 
                 GCAGUAUGCAGAUGACUGG 
                 5031 
                 CCAGUCAUCUGCAUACUGC 
                 72.9 
                 55.9 
               
               
                   
               
               
                 1701 
                 3696 
                 CAGUAUGCAGAUGACUGGA 
                 5032 
                 UCCAGUCAUCUGCAUACUG 
                 82.4 
                 65.4 
               
               
                   
               
               
                 1702 
                 3697 
                 AGUAUGCAGAUGACUGGAU 
                 5033 
                 AUCCAGUCAUCUGCAUACU 
                 78.9 
                 61.9 
               
               
                   
               
               
                 1703 
                 3698 
                 GUAUGCAGAUGACUGGAUG 
                 5034 
                 CAUCCAGUCAUCUGCAUAC 
                 72.9 
                 55.9 
               
               
                   
               
               
                 1704 
                 3699 
                 UAUGCAGAUGACUGGAUGG 
                 5035 
                 CCAUCCAGUCAUCUGCAUA 
                 59 
                 42 
               
               
                   
               
               
                 1739 
                 3700 
                 CCCAGCCCGGCCUCCUCGG 
                 5036 
                 CCGAGGAGGCCGGGCUGGG 
                 46 
                 29 
               
               
                   
               
               
                 1740 
                 3701 
                 CCAGCCCGGCCUCCUCGGC 
                 5037 
                 GCCGAGGAGGCCGGGCUGG 
                 40.6 
                 23.6 
               
               
                   
               
               
                 1741 
                 3702 
                 CAGCCCGGCCUCCUCGGCC 
                 5038 
                 GGCCGAGGAGGCCGGGCUG 
                 37.2 
                 20.2 
               
               
                   
               
               
                 1742 
                 3703 
                 AGCCCGGCCUCCUCGGCCU 
                 5039 
                 AGGCCGAGGAGGCCGGGCU 
                 57.2 
                 40.2 
               
               
                   
               
               
                 1743 
                 3704 
                 GCCCGGCCUCCUCGGCCUC 
                 5040 
                 GAGGCCGAGGAGGCCGGGC 
                 52.7 
                 35.7 
               
               
                   
               
               
                 1744 
                 3705 
                 CCCGGCCUCCUCGGCCUCC 
                 5041 
                 GGAGGCCGAGGAGGCCGGG 
                 40.5 
                 23.5 
               
               
                   
               
               
                 1745 
                 3706 
                 CCGGCCUCCUCGGCCUCCA 
                 5042 
                 UGGAGGCCGAGGAGGCCGG 
                 64.4 
                 47.4 
               
               
                   
               
               
                 1746 
                 3707 
                 CGGCCUCCUCGGCCUCCAU 
                 5043 
                 AUGGAGGCCGAGGAGGCCG 
                 71 
                 54 
               
               
                   
               
               
                 1747 
                 3708 
                 GGCCUCCUCGGCCUCCAUA 
                 5044 
                 UAUGGAGGCCGAGGAGGCC 
                 74.4 
                 57.4 
               
               
                   
               
               
                 1748 
                 3709 
                 GCCUCCUCGGCCUCCAUAC 
                 5045 
                 GUAUGGAGGCCGAGGAGGC 
                 59.4 
                 42.4 
               
               
                   
               
               
                 1749 
                 3710 
                 CCUCCUCGGCCUCCAUACC 
                 5046 
                 GGUAUGGAGGCCGAGGAGG 
                 54.2 
                 37.2 
               
               
                   
               
               
                 1750 
                 3711 
                 CUCCUCGGCCUCCAUACCC 
                 5047 
                 GGGUAUGGAGGCCGAGGAG 
                 44.6 
                 27.6 
               
               
                   
               
               
                 1751 
                 3712 
                 UCCUCGGCCUCCAUACCCU 
                 5048 
                 AGGGUAUGGAGGCCGAGGA 
                 57.6 
                 40.6 
               
               
                   
               
               
                 1752 
                 3713 
                 CCUCGGCCUCCAUACCCUC 
                 5049 
                 GAGGGUAUGGAGGCCGAGG 
                 59.4 
                 42.4 
               
               
                   
               
               
                 1753 
                 3714 
                 CUCGGCCUCCAUACCCUCC 
                 5050 
                 GGAGGGUAUGGAGGCCGAG 
                 47.2 
                 30.2 
               
               
                   
               
               
                 1754 
                 3715 
                 UCGGCCUCCAUACCCUCCU 
                 5051 
                 AGGAGGGUAUGGAGGCCGA 
                 51.3 
                 34.3 
               
               
                   
               
               
                 1755 
                 3716 
                 CGGCCUCCAUACCCUCCUA 
                 5052 
                 UAGGAGGGUAUGGAGGCCG 
                 85.3 
                 68.3 
               
               
                   
               
               
                 1756 
                 3717 
                 GGCCUCCAUACCCUCCUAG 
                 5053 
                 CUAGGAGGGUAUGGAGGCC 
                 63.5 
                 46.5 
               
               
                   
               
               
                 1757 
                 3718 
                 GCCUCCAUACCCUCCUAGA 
                 5054 
                 UCUAGGAGGGUAUGGAGGC 
                 80.9 
                 63.9 
               
               
                   
               
               
                 1758 
                 3719 
                 CCUCCAUACCCUCCUAGAA 
                 5055 
                 UUCUAGGAGGGUAUGGAGG 
                 87.4 
                 70.4 
               
               
                   
               
               
                 1759 
                 3720 
                 CUCCAUACCCUCCUAGAAG 
                 5056 
                 CUUCUAGGAGGGUAUGGAG 
                 66.2 
                 49.2 
               
               
                   
               
               
                 1760 
                 3721 
                 UCCAUACCCUCCUAGAAGG 
                 5057 
                 CCUUCUAGGAGGGUAUGGA 
                 56.5 
                 39.5 
               
               
                   
               
               
                 1761 
                 3722 
                 CCAUACCCUCCUAGAAGGG 
                 5058 
                 CCCUUCUAGGAGGGUAUGG 
                 58 
                 41 
               
               
                   
               
               
                 1762 
                 3723 
                 CAUACCCUCCUAGAAGGGA 
                 5059 
                 UCCCUUCUAGGAGGGUAUG 
                 70 
                 53 
               
               
                   
               
               
                 1763 
                 3724 
                 AUACCCUCCUAGAAGGGAU 
                 5060 
                 AUCCCUUCUAGGAGGGUAU 
                 69.6 
                 52.6 
               
               
                   
               
               
                 1764 
                 3725 
                 UACCCUCCUAGAAGGGAUG 
                 5061 
                 CAUCCCUUCUAGGAGGGUA 
                 57.9 
                 40.9 
               
               
                   
               
               
                 1765 
                 3726 
                 ACCCUCCUAGAAGGGAUGG 
                 5062 
                 CCAUCCCUUCUAGGAGGGU 
                 50.6 
                 33.6 
               
               
                   
               
               
                 1766 
                 3727 
                 CCCUCCUAGAAGGGAUGGU 
                 5063 
                 ACCAUCCCUUCUAGGAGGG 
                 64.3 
                 47.3 
               
               
                   
               
               
                 1767 
                 3728 
                 CCUCCUAGAAGGGAUGGUU 
                 5064 
                 AACCAUCCCUUCUAGGAGG 
                 77.1 
                 60.1 
               
               
                   
               
               
                 1768 
                 3729 
                 CUCCUAGAAGGGAUGGUUC 
                 5065 
                 GAACCAUCCCUUCUAGGAG 
                 66.9 
                 49.9 
               
               
                   
               
               
                 1769 
                 3730 
                 UCCUAGAAGGGAUGGUUCU 
                 5066 
                 AGAACCAUCCCUUCUAGGA 
                 72.2 
                 55.2 
               
               
                   
               
               
                 1770 
                 3731 
                 CCUAGAAGGGAUGGUUCUG 
                 5067 
                 CAGAACCAUCCCUUCUAGG 
                 70.8 
                 53.8 
               
               
                   
               
               
                 1771 
                 3732 
                 CUAGAAGGGAUGGUUCUGG 
                 5068 
                 CCAGAACCAUCCCUUCUAG 
                 57.6 
                 40.6 
               
               
                   
               
               
                 1772 
                 3733 
                 UAGAAGGGAUGGUUCUGGG 
                 5069 
                 CCCAGAACCAUCCCUUCUA 
                 53.5 
                 36.5 
               
               
                   
               
               
                 1806 
                 3734 
                 GGCAGUGCCCGCUACAACC 
                 5070 
                 GGUUGUAGCGGGCACUGCC 
                 65.6 
                 47.6 
               
               
                   
               
               
                 1807 
                 3735 
                 GCAGUGCCCGCUACAACCA 
                 5071 
                 UGGUUGUAGCGGGCACUGC 
                 82.2 
                 64.2 
               
               
                   
               
               
                 1808 
                 3736 
                 CAGUGCCCGCUACAACCAG 
                 5072 
                 CUGGUUGUAGCGGGCACUG 
                 66.1 
                 48.1 
               
               
                   
               
               
                 1809 
                 3737 
                 AGUGCCCGCUACAACCAGG 
                 5073 
                 CCUGGUUGUAGCGGGCACU 
                 58.7 
                 40.7 
               
               
                   
               
               
                 1810 
                 3738 
                 GUGCCCGCUACAACCAGGG 
                 5074 
                 CCCUGGUUGUAGCGGGCAC 
                 49.7 
                 31.7 
               
               
                   
               
               
                 1811 
                 3739 
                 UGCCCGCUACAACCAGGGC 
                 5075 
                 GCCCUGGUUGUAGCGGGCA 
                 43.9 
                 25.9 
               
               
                   
               
               
                 1812 
                 3740 
                 GCCCGCUACAACCAGGGCC 
                 5076 
                 GGCCCUGGUUGUAGCGGGC 
                 47.4 
                 29.4 
               
               
                   
               
               
                 1813 
                 3741 
                 CCCGCUACAACCAGGGCCG 
                 5077 
                 CGGCCCUGGUUGUAGCGGG 
                 53.5 
                 35.5 
               
               
                   
               
               
                 1814 
                 3742 
                 CCGCUACAACCAGGGCCGG 
                 5078 
                 CCGGCCCUGGUUGUAGCGG 
                 51.1 
                 33.1 
               
               
                   
               
               
                 1815 
                 3743 
                 CGCUACAACCAGGGCCGGA 
                 5079 
                 UCCGGCCCUGGUUGUAGCG 
                 68.4 
                 50.4 
               
               
                   
               
               
                 1816 
                 3744 
                 GCUACAACCAGGGCCGGAG 
                 5080 
                 CUCCGGCCCUGGUUGUAGC 
                 59.8 
                 41.8 
               
               
                   
               
               
                 1817 
                 3745 
                 CUACAACCAGGGCCGGAGC 
                 5081 
                 GCUCCGGCCCUGGUUGUAG 
                 50 
                 32 
               
               
                   
               
               
                 1818 
                 3746 
                 UACAACCAGGGCCGGAGCA 
                 5082 
                 UGCUCCGGCCCUGGUUGUA 
                 56.5 
                 38.5 
               
               
                   
               
               
                 1819 
                 3747 
                 ACAACCAGGGCCGGAGCAG 
                 5083 
                 CUGCUCCGGCCCUGGUUGU 
                 49.1 
                 31.1 
               
               
                   
               
               
                 1820 
                 3748 
                 CAACCAGGGCCGGAGCAGG 
                 5084 
                 CCUGCUCCGGCCCUGGUUG 
                 50.5 
                 32.5 
               
               
                   
               
               
                 1821 
                 3749 
                 AACCAGGGCCGGAGCAGGA 
                 5085 
                 UCCUGCUCCGGCCCUGGUU 
                 63.2 
                 45.2 
               
               
                   
               
               
                 1822 
                 3750 
                 ACCAGGGCCGGAGCAGGAG 
                 5086 
                 CUCCUGCUCCGGCCCUGGU 
                 49.6 
                 31.6 
               
               
                   
               
               
                 1823 
                 3751 
                 CCAGGGCCGGAGCAGGAGU 
                 5087 
                 ACUCCUGCUCCGGCCCUGG 
                 63.6 
                 45.6 
               
               
                   
               
               
                 1824 
                 3752 
                 CAGGGCCGGAGCAGGAGUG 
                 5088 
                 CACUCCUGCUCCGGCCCUG 
                 55 
                 37 
               
               
                   
               
               
                 1825 
                 3753 
                 AGGGCCGGAGCAGGAGUGG 
                 5089 
                 CCACUCCUGCUCCGGCCCU 
                 46.5 
                 28.5 
               
               
                   
               
               
                 1826 
                 3754 
                 GGGCCGGAGCAGGAGUGGG 
                 5090 
                 CCCACUCCUGCUCCGGCCC 
                 53.3 
                 35.3 
               
               
                   
               
               
                 1860 
                 3755 
                 UUUCACACCCAAACCAUCC 
                 5091 
                 GGAUGGUUUGGGUGUGAAA 
                 44 
                 26 
               
               
                   
               
               
                 1861 
                 3756 
                 UUCACACCCAAACCAUCCU 
                 5092 
                 AGGAUGGUUUGGGUGUGAA 
                 56.1 
                 38.1 
               
               
                   
               
               
                 1862 
                 3757 
                 UCACACCCAAACCAUCCUC 
                 5093 
                 GAGGAUGGUUUGGGUGUGA 
                 50.3 
                 32.3 
               
               
                   
               
               
                 1863 
                 3758 
                 CACACCCAAACCAUCCUCA 
                 5094 
                 UGAGGAUGGUUUGGGUGUG 
                 72.6 
                 54.6 
               
               
                   
               
               
                 1864 
                 3759 
                 ACACCCAAACCAUCCUCAU 
                 5095 
                 AUGAGGAUGGUUUGGGUGU 
                 71.6 
                 53.6 
               
               
                   
               
               
                 1865 
                 3760 
                 CACCCAAACCAUCCUCAUU 
                 5096 
                 AAUGAGGAUGGUUUGGGUG 
                 75.6 
                 57.6 
               
               
                   
               
               
                 1866 
                 3761 
                 ACCCAAACCAUCCUCAUUC 
                 5097 
                 GAAUGAGGAUGGUUUGGGU 
                 56 
                 38 
               
               
                   
               
               
                 1867 
                 3762 
                 CCCAAACCAUCCUCAUUCU 
                 5098 
                 AGAAUGAGGAUGGUUUGGG 
                 75.4 
                 57.4 
               
               
                   
               
               
                 1868 
                 3763 
                 CCAAACCAUCCUCAUUCUC 
                 5099 
                 GAGAAUGAGGAUGGUUUGG 
                 62.7 
                 44.7 
               
               
                   
               
               
                 1869 
                 3764 
                 CAAACCAUCCUCAUUCUCU 
                 5100 
                 AGAGAAUGAGGAUGGUUUG 
                 69.9 
                 51.9 
               
               
                   
               
               
                 1870 
                 3765 
                 AAACCAUCCUCAUUCUCUC 
                 5101 
                 GAGAGAAUGAGGAUGGUUU 
                 61.5 
                 43.5 
               
               
                   
               
               
                 1871 
                 3766 
                 AACCAUCCUCAUUCUCUCC 
                 5102 
                 GGAGAGAAUGAGGAUGGUU 
                 54 
                 36 
               
               
                   
               
               
                 1872 
                 3767 
                 ACCAUCCUCAUUCUCUCCC 
                 5103 
                 GGGAGAGAAUGAGGAUGGU 
                 45 
                 27 
               
               
                   
               
               
                 1873 
                 3768 
                 CCAUCCUCAUUCUCUCCCU 
                 5104 
                 AGGGAGAGAAUGAGGAUGG 
                 71.6 
                 53.6 
               
               
                   
               
               
                 1874 
                 3769 
                 CAUCCUCAUUCUCUCCCUC 
                 5105 
                 GAGGGAGAGAAUGAGGAUG 
                 64 
                 46 
               
               
                   
               
               
                 1875 
                 3770 
                 AUCCUCAUUCUCUCCCUCU 
                 5106 
                 AGAGGGAGAGAAUGAGGAU 
                 60.3 
                 42.3 
               
               
                   
               
               
                 1876 
                 3771 
                 UCCUCAUUCUCUCCCUCUC 
                 5107 
                 GAGAGGGAGAGAAUGAGGA 
                 59.3 
                 41.3 
               
               
                   
               
               
                 1877 
                 3772 
                 CCUCAUUCUCUCCCUCUCA 
                 5108 
                 UGAGAGGGAGAGAAUGAGG 
                 81.8 
                 63.8 
               
               
                   
               
               
                 1878 
                 3773 
                 CUCAUUCUCUCCCUCUCAG 
                 5109 
                 CUGAGAGGGAGAGAAUGAG 
                 65.2 
                 47.2 
               
               
                   
               
               
                 1879 
                 3774 
                 UCAUUCUCUCCCUCUCAGC 
                 5110 
                 GCUGAGAGGGAGAGAAUGA 
                 49 
                 31 
               
               
                   
               
               
                 1880 
                 3775 
                 CAUUCUCUCCCUCUCAGCC 
                 5111 
                 GGCUGAGAGGGAGAGAAUG 
                 53.9 
                 35.9 
               
               
                   
               
               
                 1881 
                 3776 
                 AUUCUCUCCCUCUCAGCCC 
                 5112 
                 GGGCUGAGAGGGAGAGAAU 
                 43.8 
                 25.8 
               
               
                   
               
               
                 1882 
                 3777 
                 UUCUCUCCCUCUCAGCCCU 
                 5113 
                 AGGGCUGAGAGGGAGAGAA 
                 57.1 
                 39.1 
               
               
                   
               
               
                 1883 
                 3778 
                 UCUCUCCCUCUCAGCCCUG 
                 5114 
                 CAGGGCUGAGAGGGAGAGA 
                 50.4 
                 32.4 
               
               
                   
               
               
                 1884 
                 3779 
                 CUCUCCCUCUCAGCCCUGG 
                 5115 
                 CCAGGGCUGAGAGGGAGAG 
                 49.2 
                 31.2 
               
               
                   
               
               
                 1901 
                 3780 
                 GGCCCUGCUUGGACCUCGA 
                 5116 
                 UCGAGGUCCAAGCAGGGCC 
                 86.5 
                 67.5 
               
               
                   
               
               
                 1902 
                 3781 
                 GCCCUGCUUGGACCUCGAU 
                 5117 
                 AUCGAGGUCCAAGCAGGGC 
                 79 
                 60 
               
               
                   
               
               
                 1903 
                 3782 
                 CCCUGCUUGGACCUCGAUA 
                 5118 
                 UAUCGAGGUCCAAGCAGGG 
                 84.1 
                 65.1 
               
               
                   
               
               
                 1904 
                 3783 
                 CCUGCUUGGACCUCGAUAA 
                 5119 
                 UUAUCGAGGUCCAAGCAGG 
                 90.9 
                 71.9 
               
               
                   
               
               
                 1905 
                 3784 
                 CUGCUUGGACCUCGAUAAC 
                 5120 
                 GUUAUCGAGGUCCAAGCAG 
                 67.5 
                 48.5 
               
               
                   
               
               
                 1906 
                 3785 
                 UGCUUGGACCUCGAUAACG 
                 5121 
                 CGUUAUCGAGGUCCAAGCA 
                 57.4 
                 38.4 
               
               
                   
               
               
                 1907 
                 3786 
                 GCUUGGACCUCGAUAACGG 
                 5122 
                 CCGUUAUCGAGGUCCAAGC 
                 71.9 
                 52.9 
               
               
                   
               
               
                 1908 
                 3787 
                 CUUGGACCUCGAUAACGGG 
                 5123 
                 CCCGUUAUCGAGGUCCAAG 
                 59.3 
                 40.3 
               
               
                   
               
               
                 1931 
                 3788 
                 GGGUGCCCUAGCAUCAGAA 
                 5124 
                 UUCUGAUGCUAGGGCACCC 
                 85.5 
                 66.5 
               
               
                   
               
               
                 1932 
                 3789 
                 GGUGCCCUAGCAUCAGAAG 
                 5125 
                 CUUCUGAUGCUAGGGCACC 
                 73.8 
                 54.8 
               
               
                   
               
               
                 1933 
                 3790 
                 GUGCCCUAGCAUCAGAAGG 
                 5126 
                 CCUUCUGAUGCUAGGGCAC 
                 60.7 
                 41.7 
               
               
                   
               
               
                 1934 
                 3791 
                 UGCCCUAGCAUCAGAAGGG 
                 5127 
                 CCCUUCUGAUGCUAGGGCA 
                 51.8 
                 32.8 
               
               
                   
               
               
                 1935 
                 3792 
                 GCCCUAGCAUCAGAAGGGU 
                 5128 
                 ACCCUUCUGAUGCUAGGGC 
                 71.1 
                 52.1 
               
               
                   
               
               
                 1936 
                 3793 
                 CCCUAGCAUCAGAAGGGUU 
                 5129 
                 AACCCUUCUGAUGCUAGGG 
                 80.8 
                 61.8 
               
               
                   
               
               
                 1937 
                 3794 
                 CCUAGCAUCAGAAGGGUUC 
                 5130 
                 GAACCCUUCUGAUGCUAGG 
                 68.3 
                 49.3 
               
               
                   
               
               
                 1938 
                 3795 
                 CUAGCAUCAGAAGGGUUCA 
                 5131 
                 UGAACCCUUCUGAUGCUAG 
                 81.4 
                 62.4 
               
               
                   
               
               
                 1939 
                 3796 
                 UAGCAUCAGAAGGGUUCAU 
                 5132 
                 AUGAACCCUUCUGAUGCUA 
                 68.2 
                 49.2 
               
               
                   
               
               
                 1940 
                 3797 
                 AGCAUCAGAAGGGUUCAUG 
                 5133 
                 CAUGAACCCUUCUGAUGCU 
                 59.3 
                 40.3 
               
               
                   
               
               
                 1941 
                 3798 
                 GCAUCAGAAGGGUUCAUGG 
                 5134 
                 CCAUGAACCCUUCUGAUGC 
                 69.9 
                 50.9 
               
               
                   
               
               
                 2008 
                 3799 
                 GGGCUGCAGAGAGGGUAGA 
                 5135 
                 UCUACCCUCUCUGCAGCCC 
                 79.1 
                 59.1 
               
               
                   
               
               
                 2009 
                 3800 
                 GGCUGCAGAGAGGGUAGAG 
                 5136 
                 CUCUACCCUCUCUGCAGCC 
                 68.1 
                 48.1 
               
               
                   
               
               
                 2010 
                 3801 
                 GCUGCAGAGAGGGUAGAGA 
                 5137 
                 UCUCUACCCUCUCUGCAGC 
                 80.9 
                 60.9 
               
               
                   
               
               
                 2011 
                 3802 
                 CUGCAGAGAGGGUAGAGAA 
                 5138 
                 UUCUCUACCCUCUCUGCAG 
                 86.8 
                 66.8 
               
               
                   
               
               
                 2012 
                 3803 
                 UGCAGAGAGGGUAGAGAAG 
                 5139 
                 CUUCUCUACCCUCUCUGCA 
                 68.6 
                 48.6 
               
               
                   
               
               
                 2013 
                 3804 
                 GCAGAGAGGGUAGAGAAGG 
                 5140 
                 CCUUCUCUACCCUCUCUGC 
                 65.8 
                 45.8 
               
               
                   
               
               
                 2014 
                 3805 
                 CAGAGAGGGUAGAGAAGGG 
                 5141 
                 CCCUUCUCUACCCUCUCUG 
                 64.6 
                 44.6 
               
               
                   
               
               
                 2015 
                 3806 
                 AGAGAGGGUAGAGAAGGGA 
                 5142 
                 UCCCUUCUCUACCCUCUCU 
                 73 
                 53 
               
               
                   
               
               
                 2016 
                 3807 
                 GAGAGGGUAGAGAAGGGAC 
                 5143 
                 GUCCCUUCUCUACCCUCUC 
                 67.7 
                 47.7 
               
               
                   
               
               
                 2017 
                 3808 
                 AGAGGGUAGAGAAGGGACU 
                 5144 
                 AGUCCCUUCUCUACCCUCU 
                 72.3 
                 52.3 
               
               
                   
               
               
                 2018 
                 3809 
                 GAGGGUAGAGAAGGGACUU 
                 5145 
                 AAGUCCCUUCUCUACCCUC 
                 77.2 
                 57.2 
               
               
                   
               
               
                 2019 
                 3810 
                 AGGGUAGAGAAGGGACUUU 
                 5146 
                 AAAGUCCCUUCUCUACCCU 
                 71.1 
                 51.1 
               
               
                   
               
               
                 2020 
                 3811 
                 GGGUAGAGAAGGGACUUUG 
                 5147 
                 CAAAGUCCCUUCUCUACCC 
                 72.9 
                 52.9 
               
               
                   
               
               
                 2021 
                 3812 
                 GGUAGAGAAGGGACUUUGC 
                 5148 
                 GCAAAGUCCCUUCUCUACC 
                 72.2 
                 52.2 
               
               
                   
               
               
                 2022 
                 3813 
                 GUAGAGAAGGGACUUUGCA 
                 5149 
                 UGCAAAGUCCCUUCUCUAC 
                 80.5 
                 60.5 
               
               
                   
               
               
                 2023 
                 3814 
                 UAGAGAAGGGACUUUGCAG 
                 5150 
                 CUGCAAAGUCCCUUCUCUA 
                 61.1 
                 41.1 
               
               
                   
               
               
                 2024 
                 3815 
                 AGAGAAGGGACUUUGCAGG 
                 5151 
                 CCUGCAAAGUCCCUUCUCU 
                 59.1 
                 39.1 
               
               
                   
               
               
                 2025 
                 3816 
                 GAGAAGGGACUUUGCAGGU 
                 5152 
                 ACCUGCAAAGUCCCUUCUC 
                 72.5 
                 52.5 
               
               
                   
               
               
                 2026 
                 3817 
                 AGAAGGGACUUUGCAGGUG 
                 5153 
                 CACCUGCAAAGUCCCUUCU 
                 64.1 
                 44.1 
               
               
                   
               
               
                 2027 
                 3818 
                 GAAGGGACUUUGCAGGUGA 
                 5154 
                 UCACCUGCAAAGUCCCUUC 
                 85.3 
                 65.3 
               
               
                   
               
               
                 2028 
                 3819 
                 AAGGGACUUUGCAGGUGAA 
                 5155 
                 UUCACCUGCAAAGUCCCUU 
                 83.6 
                 63.6 
               
               
                   
               
               
                 2029 
                 3820 
                 AGGGACUUUGCAGGUGAAU 
                 5156 
                 AUUCACCUGCAAAGUCCCU 
                 69.9 
                 49.9 
               
               
                   
               
               
                 2030 
                 3821 
                 GGGACUUUGCAGGUGAAUG 
                 5157 
                 CAUUCACCUGCAAAGUCCC 
                 68.8 
                 48.8 
               
               
                   
               
               
                 2031 
                 3822 
                 GGACUUUGCAGGUGAAUGG 
                 5158 
                 CCAUUCACCUGCAAAGUCC 
                 71.3 
                 51.3 
               
               
                   
               
               
                 2073 
                 3823 
                 UUUCAUCAGAGGUGGGUGG 
                 5159 
                 CCACCCACCUCUGAUGAAA 
                 47.2 
                 27.2 
               
               
                   
               
               
                 2074 
                 3824 
                 UUCAUCAGAGGUGGGUGGG 
                 5160 
                 CCCACCCACCUCUGAUGAA 
                 36.8 
                 16.8 
               
               
                   
               
               
                 2075 
                 3825 
                 UCAUCAGAGGUGGGUGGGU 
                 5161 
                 ACCCACCCACCUCUGAUGA 
                 54 
                 34 
               
               
                   
               
               
                 2076 
                 3826 
                 CAUCAGAGGUGGGUGGGUG 
                 5162 
                 CACCCACCCACCUCUGAUG 
                 60.3 
                 40.3 
               
               
                   
               
               
                 2077 
                 3827 
                 AUCAGAGGUGGGUGGGUGU 
                 5163 
                 ACACCCACCCACCUCUGAU 
                 62.7 
                 42.7 
               
               
                   
               
               
                 2078 
                 3825 
                 UCAGAGGUGGGUGGGUGUU 
                 5164 
                 AACACCCACCCACCUCUGA 
                 64.8 
                 44.8 
               
               
                   
               
               
                 2079 
                 3829 
                 CAGAGGUGGGUGGGUGUUC 
                 5165 
                 GAACACCCACCCACCUCUG 
                 62.5 
                 42.5 
               
               
                   
               
               
                 2080 
                 3830 
                 AGAGGUGGGUGGGUGUUCA 
                 5166 
                 UGAACACCCACCCACCUCU 
                 79.5 
                 59.5 
               
               
                   
               
               
                 2081 
                 3831 
                 GAGGUGGGUGGGUGUUCAC 
                 5167 
                 GUGAACACCCACCCACCUC 
                 68.7 
                 48.7 
               
               
                   
               
               
                 2082 
                 3832 
                 AGGUGGGUGGGUGUUCACA 
                 5168 
                 UGUGAACACCCACCCACCU 
                 75.5 
                 55.5 
               
               
                   
               
               
                 2083 
                 3833 
                 GGUGGGUGGGUGUUCACAA 
                 5169 
                 UUGUGAACACCCACCCACC 
                 93.7 
                 73.7 
               
               
                   
               
               
                 2084 
                 3834 
                 GUGGGUGGGUGUUCACAAU 
                 5170 
                 AUUGUGAACACCCACCCAC 
                 84.9 
                 64.9 
               
               
                   
               
               
                 2085 
                 3835 
                 UGGGUGGGUGUUCACAAUA 
                 5171 
                 UAUUGUGAACACCCACCCA 
                 80.9 
                 60.9 
               
               
                   
               
               
                 2086 
                 3836 
                 GGGUGGGUGUUCACAAUAU 
                 5172 
                 AUAUUGUGAACACCCACCC 
                 93.1 
                 73.1 
               
               
                   
               
               
                 2087 
                 3837 
                 GGUGGGUGUUCACAAUAUU 
                 5173 
                 AAUAUUGUGAACACCCACC 
                 94.8 
                 74.8 
               
               
                   
               
               
                 2088 
                 3838 
                 GUGGGUGUUCACAAUAUUU 
                 5174 
                 AAAUAUUGUGAACACCCAC 
                 85.8 
                 65.8 
               
               
                   
               
               
                 2089 
                 3839 
                 UGGGUGUUCACAAUAUUUA 
                 5175 
                 UAAAUAUUGUGAACACCCA 
                 84.3 
                 64.3 
               
               
                   
               
               
                 2090 
                 3840 
                 GGGUGUUCACAAUAUUUAU 
                 5176 
                 AUAAAUAUUGUGAACACCC 
                 96 
                 76 
               
               
                   
               
               
                 2091 
                 3841 
                 GGUGUUCACAAUAUUUAUU 
                 5177 
                 AAUAAAUAUUGUGAACACC 
                 89.4 
                 69.4 
               
               
                   
               
               
                 2092 
                 3842 
                 GUGUUCACAAUAUUUAUUU 
                 5178 
                 AAAUAAAUAUUGUGAACAC 
                 79.7 
                 59.7 
               
               
                   
               
               
                 2111 
                 3843 
                 UUUCAUUUGGUAAUGGGAG 
                 5179 
                 CUCCCAUUACCAAAUGAAA 
                 49.8 
                 28.8 
               
               
                   
               
               
                 2112 
                 3844 
                 UUCAUUUGGUAAUGGGAGG 
                 5180 
                 CCUCCCAUUACCAAAUGAA 
                 47.5 
                 26.5 
               
               
                   
               
               
                 2113 
                 3845 
                 UCAUUUGGUAAUGGGAGGG 
                 5181 
                 CCCUCCCAUUACCAAAUGA 
                 40.3 
                 19.3 
               
               
                   
               
               
                 2140 
                 3846 
                 GGGUAUUUAUUUAGGAGGG 
                 5182 
                 CCCUCCUAAAUAAAUACCC 
                 64.6 
                 43.6 
               
               
                   
               
               
                 2141 
                 3847 
                 GGUAUUUAUUUAGGAGGGA 
                 5183 
                 UCCCUCCUAAAUAAAUACC 
                 78.8 
                 57.8 
               
               
                   
               
               
                 2142 
                 3848 
                 GUAUUUAUUUAGGAGGGAG 
                 5184 
                 CUCCCUCCUAAAUAAAUAC 
                 62.4 
                 41.4 
               
               
                   
               
               
                 2143 
                 3849 
                 UAUUUAUUUAGGAGGGAGU 
                 5185 
                 ACUCCCUCCUAAAUAAAUA 
                 59.9 
                 38.9 
               
               
                   
               
               
                 2144 
                 3850 
                 AUUUAUUUAGGAGGGAGUG 
                 5186 
                 CACUCCCUCCUAAAUAAAU 
                 53.3 
                 32.3 
               
               
                   
               
               
                 2145 
                 3851 
                 UUUAUUUAGGAGGGAGUGU 
                 5187 
                 ACACUCCCUCCUAAAUAAA 
                 54.1 
                 33.1 
               
               
                   
               
               
                 2146 
                 3852 
                 UUAUUUAGGAGGGAGUGUG 
                 5188 
                 CACACUCCCUCCUAAAUAA 
                 50 
                 29 
               
               
                   
               
               
                 2147 
                 3853 
                 UAUUUAGGAGGGAGUGUGG 
                 5189 
                 CCACACUCCCUCCUAAAUA 
                 54.3 
                 33.3 
               
               
                   
               
               
                 2148 
                 3854 
                 AUUUAGGAGGGAGUGUGGU 
                 5190 
                 ACCACACUCCCUCCUAAAU 
                 57.2 
                 36.2 
               
               
                   
               
               
                 2149 
                 3855 
                 UUUAGGAGGGAGUGUGGUU 
                 5191 
                 AACCACACUCCCUCCUAAA 
                 64.1 
                 43.1 
               
               
                   
               
               
                 2150 
                 3856 
                 UUAGGAGGGAGUGUGGUUU 
                 5192 
                 AAACCACACUCCCUCCUAA 
                 61.2 
                 40.2 
               
               
                   
               
               
                 2151 
                 3857 
                 UAGGAGGGAGUGUGGUUUC 
                 5193 
                 GAAACCACACUCCCUCCUA 
                 58.6 
                 37.6 
               
               
                   
               
               
                 2152 
                 3858 
                 AGGAGGGAGUGUGGUUUCC 
                 5194 
                 GGAAACCACACUCCCUCCU 
                 59.7 
                 38.7 
               
               
                   
               
               
                 2153 
                 3859 
                 GGAGGGAGUGUGGUUUCCU 
                 5195 
                 AGGAAACCACACUCCCUCC 
                 74.6 
                 53.6 
               
               
                   
               
               
                 2154 
                 3860 
                 GAGGGAGUGUGGUUUCCUU 
                 5196 
                 AAGGAAACCACACUCCCUC 
                 83.7 
                 62.7 
               
               
                   
               
               
                 2155 
                 3861 
                 AGGGAGUGUGGUUUCCUUA 
                 5197 
                 UAAGGAAACCACACUCCCU 
                 86.5 
                 65.5 
               
               
                   
               
               
                 2156 
                 3862 
                 GGGAGUGUGGUUUCCUUAG 
                 5198 
                 CUAAGGAAACCACACUCCC 
                 79.6 
                 58.6 
               
               
                   
               
               
                 2157 
                 3863 
                 GGAGUGUGGUUUCCUUAGA 
                 5199 
                 UCUAAGGAAACCACACUCC 
                 95.1 
                 74.1 
               
               
                   
               
               
                 2158 
                 3864 
                 GAGUGUGGUUUCCUUAGAA 
                 5200 
                 UUCUAAGGAAACCACACUC 
                 96.5 
                 75.5 
               
               
                   
               
               
                 2159 
                 3865 
                 AGUGUGGUUUCCUUAGAAG 
                 5201 
                 CUUCUAAGGAAACCACACU 
                 76.7 
                 55.7 
               
               
                   
               
               
                 2160 
                 3866 
                 GUGUGGUUUCCUUAGAAGG 
                 5202 
                 CCUUCUAAGGAAACCACAC 
                 71.6 
                 50.6 
               
               
                   
               
               
                 2161 
                 3867 
                 UGUGGUUUCCUUAGAAGGU 
                 5203 
                 ACCUUCUAAGGAAACCACA 
                 73.5 
                 52.5 
               
               
                   
               
               
                 2162 
                 3868 
                 GUGGUUUCCUUAGAAGGUA 
                 5204 
                 UACCUUCUAAGGAAACCAC 
                 87.8 
                 66.8 
               
               
                   
               
               
                 2163 
                 3869 
                 UGGUUUCCUUAGAAGGUAU 
                 5205 
                 AUACCUUCUAAGGAAACCA 
                 83 
                 62 
               
               
                   
               
               
                 2164 
                 3870 
                 GGUUUCCUUAGAAGGUAUA 
                 5206 
                 UAUACCUUCUAAGGAAACC 
                 94.8 
                 73.8 
               
               
                   
               
               
                 2165 
                 3871 
                 GUUUCCUUAGAAGGUAUAG 
                 5207 
                 CUAUACCUUCUAAGGAAAC 
                 71 
                 50 
               
               
                   
               
               
                 2166 
                 3872 
                 UUUCCUUAGAAGGUAUAGU 
                 5208 
                 ACUAUACCUUCUAAGGAAA 
                 60 
                 39 
               
               
                   
               
               
                 2167 
                 3873 
                 UUCCUUAGAAGGUAUAGUC 
                 5209 
                 GACUAUACCUUCUAAGGAA 
                 57.5 
                 36.5 
               
               
                   
               
               
                 2168 
                 3874 
                 UCCUUAGAAGGUAUAGUCU 
                 5210 
                 AGACUAUACCUUCUAAGGA 
                 72.3 
                 51.3 
               
               
                   
               
               
                 2169 
                 3875 
                 CCUUAGAAGGUAUAGUCUC 
                 5211 
                 GAGACUAUACCUUCUAAGG 
                 75.3 
                 54.3 
               
               
                   
               
               
                 2170 
                 3876 
                 CUUAGAAGGUAUAGUCUCU 
                 5212 
                 AGAGACUAUACCUUCUAAG 
                 82 
                 61 
               
               
                   
               
               
                 2171 
                 3877 
                 UUAGAAGGUAUAGUCUCUA 
                 5213 
                 UAGAGACUAUACCUUCUAA 
                 75.2 
                 54.2 
               
               
                   
               
               
                 2172 
                 3878 
                 UAGAAGGUAUAGUCUCUAG 
                 5214 
                 CUAGAGACUAUACCUUCUA 
                 72.6 
                 51.6 
               
               
                   
               
               
                 2173 
                 3879 
                 AGAAGGUAUAGUCUCUAGC 
                 5215 
                 GCUAGAGACUAUACCUUCU 
                 65.7 
                 44.7 
               
               
                   
               
               
                 2174 
                 3880 
                 GAAGGUAUAGUCUCUAGCC 
                 5216 
                 GGCUAGAGACUAUACCUUC 
                 66.5 
                 45.5 
               
               
                   
               
               
                 2175 
                 3881 
                 AAGGUAUAGUCUCUAGCCC 
                 5217 
                 GGGCUAGAGACUAUACCUU 
                 57.7 
                 36.7 
               
               
                   
               
               
                 2176 
                 3882 
                 AGGUAUAGUCUCUAGCCCU 
                 5218 
                 AGGGCUAGAGACUAUACCU 
                 75.3 
                 54.3 
               
               
                   
               
               
                 2177 
                 3883 
                 GGUAUAGUCUCUAGCCCUC 
                 5219 
                 GAGGGCUAGAGACUAUACC 
                 75.5 
                 54.5 
               
               
                   
               
               
                 2178 
                 3884 
                 GUAUAGUCUCUAGCCCUCU 
                 5220 
                 AGAGGGCUAGAGACUAUAC 
                 73.3 
                 52.3 
               
               
                   
               
               
                 2179 
                 3885 
                 UAUAGUCUCUAGCCCUCUA 
                 5221 
                 UAGAGGGCUAGAGACUAUA 
                 82.5 
                 61.5 
               
               
                   
               
               
                 2180 
                 3886 
                 AUAGUCUCUAGCCCUCUAA 
                 5222 
                 UUAGAGGGCUAGAGACUAU 
                 78.2 
                 57.2 
               
               
                   
               
               
                 2181 
                 3887 
                 UAGUCUCUAGCCCUCUAAG 
                 5223 
                 CUUAGAGGGCUAGAGACUA 
                 62.8 
                 41.8 
               
               
                   
               
               
                 2182 
                 3888 
                 AGUCUCUAGCCCUCUAAGG 
                 5224 
                 CCUUAGAGGGCUAGAGACU 
                 60.6 
                 39.6 
               
               
                   
               
               
                 2183 
                 3889 
                 GUCUCUAGCCCUCUAAGGC 
                 5225 
                 GCCUUAGAGGGCUAGAGAC 
                 56.1 
                 35.1 
               
               
                   
               
               
                 2184 
                 3890 
                 UCUCUAGCCCUCUAAGGCU 
                 5226 
                 AGCCUUAGAGGGCUAGAGA 
                 62.9 
                 41.9 
               
               
                   
               
               
                 2185 
                 3891 
                 CUCUAGCCCUCUAAGGCUG 
                 5227 
                 CAGCCUUAGAGGGCUAGAG 
                 67.1 
                 46.1 
               
               
                   
               
               
                 2186 
                 3892 
                 UCUAGCCCUCUAAGGCUGG 
                 5228 
                 CCAGCCUUAGAGGGCUAGA 
                 50.6 
                 29.6 
               
               
                   
               
               
                 2187 
                 3893 
                 CUAGCCCUCUAAGGCUGGG 
                 5229 
                 CCCAGCCUUAGAGGGCUAG 
                 48.7 
                 27.7 
               
               
                   
               
               
                 2230 
                 3894 
                 AAAUGAGGAGUUUAGAGUU 
                 5230 
                 AACUCUAAACUCCUCAUUU 
                 79.8 
                 57.8 
               
               
                   
               
               
                 2231 
                 3895 
                 AAUGAGGAGUUUAGAGUUG 
                 5231 
                 CAACUCUAAACUCCUCAUU 
                 73.3 
                 51.3 
               
               
                   
               
               
                 2232 
                 3896 
                 AUGAGGAGUUUAGAGUUGC 
                 5232 
                 GCAACUCUAAACUCCUCAU 
                 59.4 
                 37.4 
               
               
                   
               
               
                 2233 
                 3897 
                 UGAGGAGUUUAGAGUUGCA 
                 5233 
                 UGCAACUCUAAACUCCUCA 
                 84.9 
                 62.9 
               
               
                   
               
               
                 2234 
                 3898 
                 GAGGAGUUUAGAGUUGCAG 
                 5234 
                 CUGCAACUCUAAACUCCUC 
                 73.3 
                 51.3 
               
               
                   
               
               
                 2235 
                 3899 
                 AGGAGUUUAGAGUUGCAGC 
                 5235 
                 GCUGCAACUCUAAACUCCU 
                 66.1 
                 44.1 
               
               
                   
               
               
                 2236 
                 3900 
                 GGAGUUUAGAGUUGCAGCU 
                 5236 
                 AGCUGCAACUCUAAACUCC 
                 85.2 
                 63.2 
               
               
                   
               
               
                 2237 
                 3901 
                 GAGUUUAGAGUUGCAGCUG 
                 5237 
                 CAGCUGCAACUCUAAACUC 
                 75.7 
                 53.7 
               
               
                   
               
               
                 2238 
                 3902 
                 AGUUUAGAGUUGCAGCUGG 
                 5238 
                 CCAGCUGCAACUCUAAACU 
                 73.1 
                 51.1 
               
               
                   
               
               
                 2239 
                 3903 
                 GUUUAGAGUUGCAGCUGGG 
                 5239 
                 CCCAGCUGCAACUCUAAAC 
                 70.2 
                 48.2 
               
               
                   
               
               
                 2262 
                 3904 
                 GGGUUUGAAGGAAGUUGGA 
                 5240 
                 UCCAACUUCCUUCAAACCC 
                 90.2 
                 68.2 
               
               
                   
               
               
                 2263 
                 3905 
                 GGUUUGAAGGAAGUUGGAA 
                 5241 
                 UUCCAACUUCCUUCAAACC 
                 91.9 
                 69.9 
               
               
                   
               
               
                 2264 
                 3906 
                 GUUUGAAGGAAGUUGGAAG 
                 5242 
                 CUUCCAACUUCCUUCAAAC 
                 73.8 
                 51.8 
               
               
                   
               
               
                 2265 
                 3907 
                 UUUGAAGGAAGUUGGAAGU 
                 5243 
                 ACUUCCAACUUCCUUCAAA 
                 64.3 
                 42.3 
               
               
                   
               
               
                 2266 
                 3908 
                 UUGAAGGAAGUUGGAAGUG 
                 5244 
                 CACUUCCAACUUCCUUCAA 
                 55.7 
                 33.7 
               
               
                   
               
               
                 2267 
                 3909 
                 UGAAGGAAGUUGGAAGUGG 
                 5245 
                 CCACUUCCAACUUCCUUCA 
                 62.8 
                 40.8 
               
               
                   
               
               
                 2268 
                 3910 
                 GAAGGAAGUUGGAAGUGGG 
                 5246 
                 CCCACUUCCAACUUCCUUC 
                 72.5 
                 50.5 
               
               
                   
               
               
                 2296 
                 3911 
                 GGGCAUCUGGUCUCAGAAA 
                 5247 
                 UUUCUGAGACCAGAUGCCC 
                 90.5 
                 68.5 
               
               
                   
               
               
                 2297 
                 3912 
                 GGCAUCUGGUCUCAGAAAU 
                 5248 
                 AUUUCUGAGACCAGAUGCC 
                 84.6 
                 62.6 
               
               
                   
               
               
                 2298 
                 3913 
                 GCAUCUGGUCUCAGAAAUG 
                 5249 
                 CAUUUCUGAGACCAGAUGC 
                 77.1 
                 55.1 
               
               
                   
               
               
                 2299 
                 3914 
                 CAUCUGGUCUCAGAAAUGG 
                 5250 
                 CCAUUUCUGAGACCAGAUG 
                 65.4 
                 43.4 
               
               
                   
               
               
                 2300 
                 3915 
                 AUCUGGUCUCAGAAAUGGA 
                 5251 
                 UCCAUUUCUGAGACCAGAU 
                 76.8 
                 53.8 
               
               
                   
               
               
                 2301 
                 3916 
                 UCUGGUCUCAGAAAUGGAC 
                 5252 
                 GUCCAUUUCUGAGACCAGA 
                 60.2 
                 37.2 
               
               
                   
               
               
                 2302 
                 3917 
                 CUGGUCUCAGAAAUGGACC 
                 5253 
                 GGUCCAUUUCUGAGACCAG 
                 55.4 
                 32.4 
               
               
                   
               
               
                 2303 
                 3918 
                 UGGUCUCAGAAAUGGACCA 
                 5254 
                 UGGUCCAUUUCUGAGACCA 
                 76 
                 53 
               
               
                   
               
               
                 2304 
                 3919 
                 GGUCUCAGAAAUGGACCAG 
                 5255 
                 CUGGUCCAUUUCUGAGACC 
                 69.7 
                 46.7 
               
               
                   
               
               
                 2305 
                 3920 
                 GUCUCAGAAAUGGACCAGC 
                 5256 
                 GCUGGUCCAUUUCUGAGAC 
                 57.5 
                 34.5 
               
               
                   
               
               
                 2306 
                 3921 
                 UCUCAGAAAUGGACCAGCU 
                 5257 
                 AGCUGGUCCAUUUCUGAGA 
                 70.1 
                 47.1 
               
               
                   
               
               
                 2307 
                 3922 
                 CUCAGAAAUGGACCAGCUG 
                 5258 
                 CAGCUGGUCCAUUUCUGAG 
                 68.4 
                 45.4 
               
               
                   
               
               
                 2308 
                 3923 
                 UCAGAAAUGGACCAGCUGG 
                 5259 
                 CCAGCUGGUCCAUUUCUGA 
                 57.5 
                 34.5 
               
               
                   
               
               
                 2309 
                 3924 
                 CAGAAAUGGACCAGCUGGA 
                 5260 
                 UCCAGCUGGUCCAUUUCUG 
                 80.1 
                 57.1 
               
               
                   
               
               
                 2310 
                 3925 
                 AGAAAUGGACCAGCUGGAU 
                 5261 
                 AUCCAGCUGGUCCAUUUCU 
                 75.1 
                 52.1 
               
               
                   
               
               
                 2311 
                 3926 
                 GAAAUGGACCAGCUGGAUG 
                 5262 
                 CAUCCAGCUGGUCCAUUUC 
                 69.3 
                 46.3 
               
               
                   
               
               
                 2312 
                 3927 
                 AAAUGGACCAGCUGGAUGC 
                 5263 
                 GCAUCCAGCUGGUCCAUUU 
                 57.6 
                 34.6 
               
               
                   
               
               
                 2313 
                 3928 
                 AAUGGACCAGCUGGAUGCA 
                 5264 
                 UGCAUCCAGCUGGUCCAUU 
                 72.5 
                 49.5 
               
               
                   
               
               
                 2314 
                 3929 
                 AUGGACCAGCUGGAUGCAG 
                 5265 
                 CUGCAUCCAGCUGGUCCAU 
                 54.7 
                 31.7 
               
               
                   
               
               
                 2315 
                 3930 
                 UGGACCAGCUGGAUGCAGG 
                 5266 
                 CCUGCAUCCAGCUGGUCCA 
                 55.8 
                 32.8 
               
               
                   
               
               
                 2316 
                 3931 
                 GGACCAGCUGGAUGCAGGG 
                 5267 
                 CCCUGCAUCCAGCUGGUCC 
                 65.9 
                 42.9 
               
               
                   
               
               
                 2317 
                 3932 
                 GACCAGCUGGAUGCAGGGC 
                 5268 
                 GCCCUGCAUCCAGCUGGUC 
                 52.3 
                 29.3 
               
               
                   
               
               
                 2318 
                 3933 
                 ACCAGCUGGAUGCAGGGCA 
                 5269 
                 UGCCCUGCAUCCAGCUGGU 
                 65.5 
                 42.5 
               
               
                   
               
               
                 2319 
                 3934 
                 CCAGCUGGAUGCAGGGCAG 
                 5270 
                 CUGCCCUGCAUCCAGCUGG 
                 70.5 
                 47.5 
               
               
                   
               
               
                 2320 
                 3935 
                 CAGCUGGAUGCAGGGCAGG 
                 5271 
                 CCUGCCCUGCAUCCAGCUG 
                 55.3 
                 32.3 
               
               
                   
               
               
                 2321 
                 3936 
                 AGCUGGAUGCAGGGCAGGG 
                 5272 
                 CCCUGCCCUGCAUCCAGCU 
                 51 
                 28 
               
               
                   
               
               
                 2338 
                 3937 
                 GGGACUGAGGGUGCUUGAG 
                 5273 
                 CUCAAGCACCCUCAGUCCC 
                 66 
                 43 
               
               
                   
               
               
                 2339 
                 3938 
                 GGACUGAGGGUGCUUGAGU 
                 5274 
                 ACUCAAGCACCCUCAGUCC 
                 74.5 
                 51.5 
               
               
                   
               
               
                 2340 
                 3939 
                 GACUGAGGGUGCUUGAGUA 
                 5275 
                 UACUCAAGCACCCUCAGUC 
                 89.2 
                 66.2 
               
               
                   
               
               
                 2341 
                 3940 
                 ACUGAGGGUGCUUGAGUAG 
                 5276 
                 CUACUCAAGCACCCUCAGU 
                 66.2 
                 43.2 
               
               
                   
               
               
                 2342 
                 3941 
                 CUGAGGGUGCUUGAGUAGG 
                 5277 
                 CCUACUCAAGCACCCUCAG 
                 56.4 
                 33.4 
               
               
                   
               
               
                 2343 
                 3942 
                 UGAGGGUGCUUGAGUAGGA 
                 5278 
                 UCCUACUCAAGCACCCUCA 
                 76.1 
                 53.1 
               
               
                   
               
               
                 2344 
                 3943 
                 GAGGGUGCUUGAGUAGGAU 
                 5279 
                 AUCCUACUCAAGCACCCUC 
                 79.7 
                 56.7 
               
               
                   
               
               
                 2345 
                 3944 
                 AGGGUGCUUGAGUAGGAUG 
                 5280 
                 CAUCCUACUCAAGCACCCU 
                 67.9 
                 44.9 
               
               
                   
               
               
                 2346 
                 3945 
                 GGGUGCUUGAGUAGGAUGU 
                 5281 
                 ACAUCCUACUCAAGCACCC 
                 80.9 
                 57.9 
               
               
                   
               
               
                 2347 
                 3946 
                 GGUGCUUGAGUAGGAUGUG 
                 5282 
                 CACAUCCUACUCAAGCACC 
                 76.9 
                 53.9 
               
               
                   
               
               
                 2348 
                 3947 
                 GUGCUUGAGUAGGAUGUGA 
                 5283 
                 UCACAUCCUACUCAAGCAC 
                 85.4 
                 62.4 
               
               
                   
               
               
                 2349 
                 3948 
                 UGCUUGAGUAGGAUGUGAG 
                 5284 
                 CUCACAUCCUACUCAAGCA 
                 66.3 
                 43.3 
               
               
                   
               
               
                 2350 
                 3949 
                 GCUUGAGUAGGAUGUGAGA 
                 5285 
                 UCUCACAUCCUACUCAAGC 
                 93.2 
                 70.2 
               
               
                   
               
               
                 2351 
                 3950 
                 CUUGAGUAGGAUGUGAGAC 
                 5286 
                 GUCUCACAUCCUACUCAAG 
                 63.4 
                 40.4 
               
               
                   
               
               
                 2352 
                 3951 
                 UUGAGUAGGAUGUGAGACU 
                 5287 
                 AGUCUCACAUCCUACUCAA 
                 65 
                 42 
               
               
                   
               
               
                 2353 
                 3952 
                 UGAGUAGGAUGUGAGACUU 
                 5288 
                 AAGUCUCACAUCCUACUCA 
                 78.8 
                 55.8 
               
               
                   
               
               
                 2354 
                 3953 
                 GAGUAGGAUGUGAGACUUC 
                 5289 
                 GAAGUCUCACAUCCUACUC 
                 77.3 
                 54.3 
               
               
                   
               
               
                 2355 
                 3954 
                 AGUAGGAUGUGAGACUUCA 
                 5290 
                 UGAAGUCUCACAUCCUACU 
                 89.3 
                 66.3 
               
               
                   
               
               
                 2356 
                 3955 
                 GUAGGAUGUGAGACUUCAU 
                 5291 
                 AUGAAGUCUCACAUCCUAC 
                 85.3 
                 65.3 
               
               
                   
               
               
                 2357 
                 3956 
                 UAGGAUGUGAGACUUCAUG 
                 5292 
                 CAUGAAGUCUCACAUCCUA 
                 63 
                 40 
               
               
                   
               
               
                 2358 
                 3957 
                 AGGAUGUGAGACUUCAUGG 
                 5293 
                 CCAUGAAGUCUCACAUCCU 
                 65.9 
                 42.9 
               
               
                   
               
               
                 2359 
                 3958 
                 GGAUGUGAGACUUCAUGGG 
                 5294 
                 CCCAUGAAGUCUCACAUCC 
                 70.7 
                 47.7 
               
               
                   
               
               
                 2360 
                 3959 
                 GAUGUGAGACUUCAUGGGC 
                 5295 
                 GCCCAUGAAGUCUCACAUC 
                 61.5 
                 38.5 
               
               
                   
               
               
                 2361 
                 3960 
                 AUGUGAGACUUCAUGGGCC 
                 5296 
                 GGCCCAUGAAGUCUCACAU 
                 49.9 
                 26.9 
               
               
                   
               
               
                 2362 
                 3961 
                 UGUGAGACUUCAUGGGCCU 
                 5297 
                 AGGCCCAUGAAGUCUCACA 
                 66.8 
                 43.8 
               
               
                   
               
               
                 2363 
                 3962 
                 GUGAGACUUCAUGGGCCUG 
                 5298 
                 CAGGCCCAUGAAGUCUCAC 
                 59.5 
                 36.5 
               
               
                   
               
               
                 2364 
                 3963 
                 UGAGACUUCAUGGGCCUGG 
                 5299 
                 CCAGGCCCAUGAAGUCUCA 
                 43.8 
                 20.8 
               
               
                   
               
               
                 2365 
                 3964 
                 GAGACUUCAUGGGCCUGGG 
                 5300 
                 CCCAGGCCCAUGAAGUCUC 
                 55.5 
                 32.5 
               
               
                   
               
               
                 2366 
                 3965 
                 AGACUUCAUGGGCCUGGGU 
                 5301 
                 ACCCAGGCCCAUGAAGUCU 
                 61 
                 38 
               
               
                   
               
               
                 2367 
                 3966 
                 GACUUCAUGGGCCUGGGUU 
                 5302 
                 AACCCAGGCCCAUGAAGUC 
                 67 
                 44 
               
               
                   
               
               
                 2368 
                 3967 
                 ACUUCAUGGGCCUGGGUUC 
                 5303 
                 GAACCCAGGCCCAUGAAGU 
                 56.4 
                 33.4 
               
               
                   
               
               
                 2369 
                 3968 
                 CUUCAUGGGCCUGGGUUCU 
                 5304 
                 AGAACCCAGGCCCAUGAAG 
                 61.3 
                 38.3 
               
               
                   
               
               
                 2370 
                 3969 
                 UUCAUGGGCCUGGGUUCUG 
                 5305 
                 CAGAACCCAGGCCCAUGAA 
                 42.7 
                 19.7 
               
               
                   
               
               
                 2371 
                 3970 
                 UCAUGGGCCUGGGUUCUGU 
                 5306 
                 ACAGAACCCAGGCCCAUGA 
                 57.2 
                 34.2 
               
               
                   
               
               
                 2372 
                 3971 
                 CAUGGGCCUGGGUUCUGUU 
                 5307 
                 AACAGAACCCAGGCCCAUG 
                 71.8 
                 48.8 
               
               
                   
               
               
                 2373 
                 3972 
                 AUGGGCCUGGGUUCUGUUG 
                 5308 
                 CAACAGAACCCAGGCCCAU 
                 53.4 
                 30.4 
               
               
                   
               
               
                 2374 
                 3973 
                 UGGGCCUGGGUUCUGUUGA 
                 5309 
                 UCAACAGAACCCAGGCCCA 
                 65.7 
                 42.7 
               
               
                   
               
               
                 2375 
                 3974 
                 GGGCCUGGGUUCUGUUGAG 
                 5310 
                 CUCAACAGAACCCAGGCCC 
                 71.5 
                 48.5 
               
               
                   
               
               
                 2376 
                 3975 
                 GGCCUGGGUUCUGUUGAGU 
                 5311 
                 ACUCAACAGAACCCAGGCC 
                 72.9 
                 49.9 
               
               
                   
               
               
                 2377 
                 3976 
                 GCCUGGGUUCUGUUGAGUU 
                 5312 
                 AACUCAACAGAACCCAGGC 
                 82.3 
                 59.3 
               
               
                   
               
               
                 2378 
                 3977 
                 CCUGGGUUCUGUUGAGUUU 
                 5313 
                 AAACUCAACAGAACCCAGG 
                 88.6 
                 65.6 
               
               
                   
               
               
                 2397 
                 3978 
                 UUUCAGUAUCAAUUUCUUA 
                 5314 
                 UAAGAAAUUGAUACUGAAA 
                 78.5 
                 55.5 
               
               
                   
               
               
                 2398 
                 3979 
                 UUCAGUAUCAAUUUCUUAA 
                 5315 
                 UUAAGAAAUUGAUACUGAA 
                 78.5 
                 55.5 
               
               
                   
               
               
                 2399 
                 3980 
                 UCAGUAUCAAUUUCUUAAA 
                 5316 
                 UUUAAGAAAUUGAUACUGA 
                 83.1 
                 60.1 
               
               
                   
               
               
                 2400 
                 3981 
                 CAGUAUCAAUUUCUUAAAC 
                 5317 
                 GUUUAAGAAAUUGAUACUG 
                 71.7 
                 47.7 
               
               
                   
               
               
                 2401 
                 3982 
                 AGUAUCAAUUUCUUAAACC 
                 5318 
                 GGUUUAAGAAAUUGAUACU 
                 59.3 
                 35.3 
               
               
                   
               
               
                 2402 
                 3983 
                 GUAUCAAUUUCUUAAACCA 
                 5319 
                 UGGUUUAAGAAAUUGAUAC 
                 86.3 
                 62.3 
               
               
                   
               
               
                 2403 
                 3984 
                 UAUCAAUUUCUUAAACCAA 
                 5320 
                 UUGGUUUAAGAAAUUGAUA 
                 82.9 
                 58.9 
               
               
                   
               
               
                 2404 
                 3985 
                 AUCAAUUUCUUAAACCAAA 
                 5321 
                 UUUGGUUUAAGAAAUUGAU 
                 84.3 
                 60.3 
               
               
                   
               
               
                 2405 
                 3986 
                 UCAAUUUCUUAAACCAAAU 
                 5322 
                 AUUUGGUUUAAGAAAUUGA 
                 76.7 
                 52.7 
               
               
                   
               
               
                 2406 
                 3987 
                 CAAUUUCUUAAACCAAAUU 
                 5323 
                 AAUUUGGUUUAAGAAAUUG 
                 79.7 
                 55.7 
               
               
                   
               
               
                 2407 
                 3988 
                 AAUUUCUUAAACCAAAUUU 
                 5324 
                 AAAUUUGGUUUAAGAAAUU 
                 71.1 
                 47.1 
               
               
                   
               
               
                 2445 
                 3989 
                 GGGUGCUCAUCUCGUGACC 
                 5325 
                 GGUCACGAGAUGAGCACCC 
                 64 
                 40 
               
               
                   
               
               
                 2446 
                 3990 
                 GGUGCUCAUCUCGUGACCU 
                 5326 
                 AGGUCACGAGAUGAGCACC 
                 72.9 
                 48.9 
               
               
                   
               
               
                 2447 
                 3991 
                 GUGCUCAUCUCGUGACCUC 
                 5327 
                 GAGGUCACGAGAUGAGCAC 
                 63.8 
                 39.8 
               
               
                   
               
               
                 2448 
                 3992 
                 UGCUCAUCUCGUGACCUCU 
                 5328 
                 AGAGGUCACGAGAUGAGCA 
                 66.7 
                 42.7 
               
               
                   
               
               
                 2449 
                 3993 
                 GCUCAUCUCGUGACCUCUG 
                 5329 
                 CAGAGGUCACGAGAUGAGC 
                 71.5 
                 47.5 
               
               
                   
               
               
                 2450 
                 3994 
                 CUCAUCUCGUGACCUCUGC 
                 5330 
                 GCAGAGGUCACGAGAUGAG 
                 54.8 
                 30.8 
               
               
                   
               
               
                 2451 
                 3995 
                 UCAUCUCGUGACCUCUGCC 
                 5331 
                 GGCAGAGGUCACGAGAUGA 
                 45.1 
                 21.1 
               
               
                   
               
               
                 2468 
                 3996 
                 CCACCCACAUCCUUCACAA 
                 5332 
                 UUGUGAAGGAUGUGGGUGG 
                 86.4 
                 62.4 
               
               
                   
               
               
                 2469 
                 3997 
                 CACCCACAUCCUUCACAAA 
                 5333 
                 UUUGUGAAGGAUGUGGGUG 
                 88.7 
                 64.7 
               
               
                   
               
               
                 2470 
                 3998 
                 ACCCACAUCCUUCACAAAC 
                 5334 
                 GUUUGUGAAGGAUGUGGGU 
                 59.7 
                 35.7 
               
               
                   
               
               
                 2471 
                 3999 
                 CCCACAUCCUUCACAAACU 
                 5335 
                 AGUUUGUGAAGGAUGUGGG 
                 77.3 
                 53.3 
               
               
                   
               
               
                 2472 
                 4000 
                 CCACAUCCUUCACAAACUC 
                 5336 
                 GAGUUUGUGAAGGAUGUGG 
                 71.6 
                 47.6 
               
               
                   
               
               
                 2473 
                 4001 
                 CACAUCCUUCACAAACUCC 
                 5337 
                 GGAGUUUGUGAAGGAUGUG 
                 61.1 
                 37.1 
               
               
                   
               
               
                 2474 
                 4002 
                 ACAUCCUUCACAAACUCCA 
                 5338 
                 UGGAGUUUGUGAAGGAUGU 
                 76.9 
                 52.9 
               
               
                   
               
               
                 2475 
                 4003 
                 CAUCCUUCACAAACUCCAU 
                 5339 
                 AUGGAGUUUGUGAAGGAUG 
                 83 
                 59 
               
               
                   
               
               
                 2476 
                 4004 
                 AUCCUUCACAAACUCCAUG 
                 5340 
                 CAUGGAGUUUGUGAAGGAU 
                 57 
                 33 
               
               
                   
               
               
                 2477 
                 4005 
                 UCCUUCACAAACUCCAUGU 
                 5341 
                 ACAUGGAGUUUGUGAAGGA 
                 63.5 
                 39.5 
               
               
                   
               
               
                 2478 
                 4006 
                 CCUUCACAAACUCCAUGUU 
                 5342 
                 AACAUGGAGUUUGUGAAGG 
                 82.2 
                 58.2 
               
               
                   
               
               
                 2479 
                 4007 
                 CUUCACAAACUCCAUGUUU 
                 5343 
                 AAACAUGGAGUUUGUGAAG 
                 78.4 
                 54.4 
               
               
                   
               
               
                 2480 
                 4008 
                 UUCACAAACUCCAUGUUUC 
                 5344 
                 GAAACAUGGAGUUUGUGAA 
                 59.9 
                 35.9 
               
               
                   
               
               
                 2481 
                 4009 
                 UCACAAACUCCAUGUUUCA 
                 5345 
                 UGAAACAUGGAGUUUGUGA 
                 79.7 
                 55.7 
               
               
                   
               
               
                 2482 
                 4010 
                 CACAAACUCCAUGUUUCAG 
                 5346 
                 CUGAAACAUGGAGUUUGUG 
                 68.6 
                 44.6 
               
               
                   
               
               
                 2483 
                 4011 
                 ACAAACUCCAUGUUUCAGU 
                 5347 
                 ACUGAAACAUGGAGUUUGU 
                 66.8 
                 42.8 
               
               
                   
               
               
                 2484 
                 4012 
                 CAAACUCCAUGUUUCAGUG 
                 5348 
                 CACUGAAACAUGGAGUUUG 
                 72.7 
                 48.7 
               
               
                   
               
               
                 2485 
                 4013 
                 AAACUCCAUGUUUCAGUGU 
                 5349 
                 ACACUGAAACAUGGAGUUU 
                 68.1 
                 44.1 
               
               
                   
               
               
                 2486 
                 4014 
                 AACUCCAUGUUUCAGUGUU 
                 5350 
                 AACACUGAAACAUGGAGUU 
                 77.6 
                 53.6 
               
               
                   
               
               
                 2487 
                 4015 
                 ACUCCAUGUUUCAGUGUUU 
                 5351 
                 AAACACUGAAACAUGGAGU 
                 85.1 
                 61.1 
               
               
                   
               
               
                 2488 
                 4016 
                 CUCCAUGUUUCAGUGUUUG 
                 5352 
                 CAAACACUGAAACAUGGAG 
                 71.2 
                 47.2 
               
               
                   
               
               
                 2489 
                 4017 
                 UCCAUGUUUCAGUGUUUGA 
                 5353 
                 UCAAACACUGAAACAUGGA 
                 80.2 
                 56.2 
               
               
                   
               
               
                 2490 
                 4018 
                 CCAUGUUUCAGUGUUUGAG 
                 5354 
                 CUCAAACACUGAAACAUGG 
                 71.9 
                 47.9 
               
               
                   
               
               
                 2491 
                 4019 
                 CAUGUUUCAGUGUUUGAGU 
                 5355 
                 ACUCAAACACUGAAACAUG 
                 79.2 
                 55.2 
               
               
                   
               
               
                 2492 
                 4020 
                 AUGUUUCAGUGUUUGAGUC 
                 5356 
                 GACUCAAACACUGAAACAU 
                 65.4 
                 41.4 
               
               
                   
               
               
                 2493 
                 4021 
                 UGUUUCAGUGUUUGAGUCC 
                 5357 
                 GGACUCAAACACUGAAACA 
                 60.4 
                 36.4 
               
               
                   
               
               
                 2494 
                 4022 
                 GUUUCAGUGUUUGAGUCCA 
                 5358 
                 UGGACUCAAACACUGAAAC 
                 86.3 
                 62.3 
               
               
                   
               
               
                 2495 
                 4023 
                 UUUCAGUGUUUGAGUCCAU 
                 5359 
                 AUGGACUCAAACACUGAAA 
                 73.5 
                 49.5 
               
               
                   
               
               
                 2496 
                 4024 
                 UUCAGUGUUUGAGUCCAUG 
                 5360 
                 CAUGGACUCAAACACUGAA 
                 58.6 
                 34.6 
               
               
                   
               
               
                 2497 
                 4025 
                 UCAGUGUUUGAGUCCAUGU 
                 5361 
                 ACAUGGACUCAAACACUGA 
                 71.3 
                 47.3 
               
               
                   
               
               
                 2498 
                 4026 
                 CAGUGUUUGAGUCCAUGUU 
                 5362 
                 AACAUGGACUCAAACACUG 
                 86.7 
                 62.7 
               
               
                   
               
               
                 2499 
                 4027 
                 AGUGUUUGAGUCCAUGUUU 
                 5363 
                 AAACAUGGACUCAAACACU 
                 85.1 
                 61.1 
               
               
                   
               
               
                 2500 
                 4028 
                 GUGUUUGAGUCCAUGUUUA 
                 5364 
                 UAAACAUGGACUCAAACAC 
                 95.3 
                 70.3 
               
               
                   
               
               
                 2501 
                 4029 
                 UGUUUGAGUCCAUGUUUAU 
                 5365 
                 AUAAACAUGGACUCAAACA 
                 83 
                 58 
               
               
                   
               
               
                 2502 
                 4030 
                 GUUUGAGUCCAUGUUUAUU 
                 5366 
                 AAUAAACAUGGACUCAAAC 
                 80.4 
                 55.4 
               
               
                   
               
               
                 2503 
                 4031 
                 UUUGAGUCCAUGUUUAUUC 
                 5367 
                 GAAUAAACAUGGACUCAAA 
                 54.1 
                 29.1 
               
               
                   
               
               
                 2504 
                 4032 
                 UUGAGUCCAUGUUUAUUCU 
                 5368 
                 AGAAUAAACAUGGACUCAA 
                 68.4 
                 43.4 
               
               
                   
               
               
                 2505 
                 4033 
                 UGAGUCCAUGUUUAUUCUG 
                 5369 
                 CAGAAUAAACAUGGACUCA 
                 62.9 
                 37.9 
               
               
                   
               
               
                 2506 
                 4034 
                 GAGUCCAUGUUUAUUCUGC 
                 5370 
                 GCAGAAUAAACAUGGACUC 
                 65.5 
                 40.5 
               
               
                   
               
               
                 2507 
                 4035 
                 AGUCCAUGUUUAUUCUGCA 
                 5371 
                 UGCAGAAUAAACAUGGACU 
                 84.3 
                 59.3 
               
               
                   
               
               
                 2508 
                 4036 
                 GUCCAUGUUUAUUCUGCAA 
                 5372 
                 UUGCAGAAUAAACAUGGAC 
                 93.4 
                 68.4 
               
               
                   
               
               
                 2509 
                 4037 
                 UCCAUGUUUAUUCUGCAAA 
                 5373 
                 UUUGCAGAAUAAACAUGGA 
                 78.1 
                 53.1 
               
               
                   
               
               
                 2510 
                 4038 
                 CCAUGUUUAUUCUGCAAAU 
                 5374 
                 AUUUGCAGAAUAAACAUGG 
                 90 
                 65 
               
               
                   
               
               
                 2511 
                 4039 
                 CAUGUUUAUUCUGCAAAUA 
                 5375 
                 UAUUUGCAGAAUAAACAUG 
                 91.3 
                 66.3 
               
               
                   
               
               
                 2512 
                 4040 
                 AUGUUUAUUCUGCAAAUAA 
                 5376 
                 UUAUUUGCAGAAUAAACAU 
                 87 
                 62 
               
               
                   
               
               
                 2513 
                 4041 
                 UGUUUAUUCUGCAAAUAAA 
                 5377 
                 UUUAUUUGCAGAAUAAACA 
                 94.1 
                 69.1 
               
               
                   
               
               
                 2514 
                 4042 
                 GUUUAUUCUGCAAAUAAAU 
                 5378 
                 AUUUAUUUGCAGAAUAAAC 
                 86.6 
                 61.6 
               
               
                   
               
               
                 2515 
                 4043 
                 UUUAUUCUGCAAAUAAAUG 
                 5379 
                 CAUUUAUUUGCAGAAUAAA 
                 57.2 
                 32.2 
               
               
                   
               
               
                 2516 
                 4044 
                 UUAUUCUGCAAAUAAAUGG 
                 5380 
                 CCAUUUAUUUGCAGAAUAA 
                 51.5 
                 26.5 
               
               
                   
               
               
                 2517 
                 4045 
                 UAUUCUGCAAAUAAAUGGU 
                 5381 
                 ACCAUUUAUUUGCAGAAUA 
                 66.6 
                 41.6 
               
               
                   
               
               
                 2518 
                 4046 
                 AUUCUGCAAAUAAAUGGUA 
                 5382 
                 UACCAUUUAUUUGCAGAAU 
                 77.5 
                 52.5 
               
               
                   
               
               
                 2519 
                 4047 
                 UUCUGCAAAUAAAUGGUAA 
                 5383 
                 UUACCAUUUAUUUGCAGAA 
                 78.4 
                 53.4 
               
               
                   
               
               
                 2520 
                 4048 
                 UCUGCAAAUAAAUGGUAAU 
                 5384 
                 AUUACCAUUUAUUUGCAGA 
                 74.4 
                 49.4 
               
               
                   
               
               
                 2521 
                 4049 
                 CUGCAAAUAAAUGGUAAUG 
                 5385 
                 CAUUACCAUUUAUUUGCAG 
                 64.5 
                 39.5 
               
               
                   
               
               
                 2522 
                 4050 
                 UGCAAAUAAAUGGUAAUGU 
                 5386 
                 ACAUUACCAUUUAUUUGCA 
                 66.3 
                 41.3 
               
               
                   
               
               
                 2523 
                 4051 
                 GCAAAUAAAUGGUAAUGUA 
                 5387 
                 UACAUUACCAUUUAUUUGC 
                 98.6 
                 73.6 
               
               
                   
               
               
                 2524 
                 4052 
                 CAAAUAAAUGGUAAUGUAU 
                 5388 
                 AUACAUUACCAUUUAUUUG 
                 87.1 
                 62.1 
               
               
                   
               
               
                 2525 
                 4053 
                 AAAUAAAUGGUAAUGUAUU 
                 5389 
                 AAUACAUUACCAUUUAUUU 
                 77.4 
                 52.4 
               
               
                   
               
               
                 2526 
                 4054 
                 AAUAAAUGGUAAUGUAUUG 
                 5390 
                 CAAUACAUUACCAUUUAUU 
                 71.2 
                 46.2 
               
               
                   
               
               
                 2527 
                 4055 
                 AUAAAUGGUAAUGUAUUGG 
                 5391 
                 CCAAUACAUUACCAUUUAU 
                 52.6 
                 27.6 
               
               
                   
               
               
                 2528 
                 4056 
                 UAAAUGGUAAUGUAUUGGA 
                 5392 
                 UCCAAUACAUUACCAUUUA 
                 71 
                 46 
               
               
                   
               
            
           
         
       
     
     In Table 5, “Pos.” refers to the position of the siRNA in the GPC2 input sequence. In this case, position 1 of SEQ ID NO: 1 corresponds to position 1 of siRNA positions listed in Table 5. “Score” refers to the predicted efficacy calculated from the SDIR 19 bp model, and “Corr. Score”, or Corrected Score refers to the previous efficacy score minored by the penalties from some intrinsic target features that can influence siRNA efficacy. Each row in Table 5 includes a sense region and complementary antisense region of a duplex of a representative siRNA of the disclosure. 
     In some embodiments, the sense region comprises a sequence selected from the group listed in Table 5. In some embodiments, the anti-sense region comprises a sequence selected from the group listed in Table 5. In some embodiments, the sense and anti-sense regions comprise complementary sequences selected from the group listed in Table 45 
     In some embodiments, the siRNA comprises a linker, sometimes referred to as a loop. siRNAs comprising a linker or loop are sometimes referred to as short hairpin RNAs (shRNAs). In some embodiments, both the sense and the anti-sense regions of the siRNA are encoded by one single-stranded RNA. In these embodiments, and the anti-sense region and the sense region hybridize to form a duplex region. The sense and anti-sense regions are joined by a linker sequence, forming a “hairpin” or “stem-loop” structure. The siRNA can have complementary sense and anti-sense regions at opposing ends of a single stranded molecule, so that the molecule can form a duplex region with the complementary sequence portions, and the strands are linked at one end of the duplex region by a linker. The linker can be either a nucleotide or non-nucleotide linker. The linker can interact with the first, and optionally, second strands through covalent bonds or non-covalent interactions. 
     Any suitable nucleotide linker sequence is envisaged as within the scope of the disclosure. An siRNA of this disclosure may include a nucleotide, non-nucleotide, or mixed nucleotide/non-nucleotide linker that joins the sense region of the nucleic acid to the anti-sense region of the nucleic acid. A nucleotide linker can be a linker of &gt;2 nucleotides in length, for example about 3, 4, 5, 6, 7, 8, 9, or 10 nucleotides in length. 
     Examples of a non-nucleotide linker include an abasic nucleotide, polyether, polyamine, polyamide, peptide, carbohydrate, lipid, polyhydrocarbon, or other polymeric agents, for example polyethylene glycols such as those having from 2 to 100 ethylene glycol units. Some examples are described in Seela et al., Nucleic Acids Research, 1987, Vol. 15, pp. 3113-3129; Cload et al., J. Am. Chem. Soc, 1991, Vol. 113, pp. 6324-6326; Jaeschke et al., Tetrahedron Lett., 1993, Vol. 34, pp. 301; Arnold et al., WO 1989/002439; Usman et al., WO 1995/006731; Dudycz et al., WO 1995/011910, and Ferentz et al., J. Am. Chem. Soc, 1991, Vol. 113, pp. 4000-4002. 
     Examples of nucleotide linker sequences include, but are not limited to, AUG, CCC, UUCG, CCACC, AAGCAA, CCACACC and UUCAAGAGA. 
     In some embodiments, the siRNA encoded by a single RNA further comprises an overhang region, as described herein. 
     In some embodiments, an siRNA can be a dsRNA of a length suitable as a Dicer substrate, which can be processed to produce a RISC active siRNA molecule. See, e.g., Rossi et al., US2005/0244858. 
     A Dicer substrate double stranded RNA (dsRNA) can be of a length sufficient that it is processed by Dicer to produce an active siRNA, and may further include one or more of the following properties: (i) the Dicer substrate dsRNA can be asymmetric, for example, having a 3′ overhang on the anti-sense strand, (ii) the Dicer substrate dsRNA can have a modified 3′ end on the sense strand to direct orientation of Dicer binding and processing of the dsRNA to an active siRNA, for example the incorporation of one or more DNA nucleotides, and (iii) the first and second strands of the Dicer substrate ds RNA can from 21-30 bp in length. 
     In some embodiments, the siRNA comprises at least one modified nucleotide. In some embodiments, the at least one modified nucleotide increases the stability of the RNA duplex, and siRNA. 
     Modifications that increase RNA stability include, but are not limited to locked nucleic acids. As used herein, the term “locked nucleic acid” or “LNA” includes, but is not limited to, a modified RNA nucleotide in which the ribose moiety comprises a methylene bridge connecting the 2′ oxygen and the 4′ carbon. This methylene bridge locks the ribose in the 3′-endo confirmation, also known as the north confirmation, that is found in A-form RNA duplexes. The term inaccessible RNA can be used interchangeably with LNA. LNAs having a 2′-4′ cyclic linkage, as described in the International Patent Application WO 99/14226, WO 00/56746, WO 00/56748, and WO 00/66604, the contents of which are incorporated herein by reference. 
     In some embodiments, the at least one modified nucleotide comprises a phosphorothioate derivative or an acridinine substituted nucleotide. 
     In some embodiments, the modified nucleotide comprises 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomet-hyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methyl-aminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N-isopenten-yladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, or 2,6-diaminopurine. 
     Nanoparticles 
     The disclosure provides nanoparticles comprising dsRNAs targeting a GPC2 mRNA for degradation. In some embodiments, the dsRNA is an siRNA, as described herein. 
     In some embodiments, the nanoparticles comprise siRNAs targeting a GPC2 mRNA sequence, and the siRNAs comprise a sense region and anti-sense region complementary to the sense region that together form an RNA duplex, and the sense region comprises a sequence at least 70% identical to a glypican-2 (GPC2) mRNA sequence. 
     In some embodiments, the nanoparticle comprises a liposome, a micelle, a polymer-based nanoparticle, a lipid-polymer based nanoparticle, a metal based nanoparticle, a carbon nanotube based nanoparticle, a nanocrystal or a polymeric micelle. In some embodiments, the polymer-based nanoparticle comprises a multiblock copolymer, a diblock copolymer, a polymeric micelle or a hyperbranched macromolecule. In some embodiments, the polymer-based nanoparticle comprises a multiblock copolymer a diblock copolymer. In some embodiments, the polymer-based nanoparticle is pH responsive. In some embodiments, the polymer-based nanoparticle further comprises a buffering component. 
     In some embodiments, the nanoparticle comprises a liposome. Liposomes are spherical vesicles having at least one lipid bilayer, and in some embodiments, an aqueous core. In some embodiments, the lipid bilayer of the liposome may comprise phospholipids. An exemplary but non-limiting example of a phospholipid is phosphatidylcholine, but the lipid bilayer may comprise additional lipids, such as phosphatidylethanolamine. Liposomes may be multilamellar, i.e. consisting of several lamellar phase lipid bilayers, or unilamellar liposomes with a single lipid bilayer. Liposomes can be made in a particular size range that makes them viable targets for phagocytosis. Liposomes can range in size from 20 nm to 100 nm, 100 nm to 400 nm, 1 μM and larger, or 200 nm to 3 μM. Examples of lipidoids and lipid-based formulations are provided in U.S. Published Application 20090023673. In other embodiments, the one or more lipids are one or more cationic lipids. One skilled in the art will recognize which liposomes are appropriate for siRNA encapsulation. 
     In some embodiments, the nanoparticle comprises a micelle. A micelle is an aggregate of surfactant molecules. An exemplary micelle comprises an aggregate of amphiphilic macromolecules, polymers or copolymers in aqueous solution, wherein the hydrophilic head portions contact the surrounding solvent, while the hydrophobic tail regions are sequestered in the center of the micelle. 
     In some embodiments, the nanoparticle comprises a nanocrystal. Exemplary nanocrystals are crystalline particles with at least one dimension of less than 1000 nanometers, preferably of less than 100 nanometers. 
     In some embodiments, the nanoparticle comprises a polymer based nanoparticle. In some embodiments, the polymer comprises a multiblock copolymer, a diblock copolymer, a polymeric micelle or a hyperbranched macromolecule. In some embodiments, the particle comprises one or more cationic polymers. In some embodiments, the cationic polymer is chitosan, protamine, polylysine, polyhistidine, polyarginine or poly(ethylene)imine. In other embodiments, the one or more polymers contain the buffering component, degradable component, hydrophilic component, cleavable bond component or some combination thereof. 
     In some embodiments, the nanoparticles or some portion thereof are degradable. In other embodiments, the lipids and/or polymers of the nanoparticles are degradable. 
     In some embodiments, any of these nanoparticles can comprise a buffering component. In other embodiments, any of the nanoparticles can comprise a buffering component and a degradable component. In still other embodiments, any of the nanoparticles can comprise a buffering component and a hydrophilic component. In yet other embodiments, any of the nanoparticles can comprise a buffering component and a cleavable bond component. In yet other embodiments, any of the nanoparticles can comprise a buffering component, a degradable component and a hydrophilic component. In still other embodiments, any of the nanoparticles can comprise a buffering component, a degradable component and a cleavable bond component. In further embodiments, any of the nanoparticles can comprise a buffering component, a hydrophilic component and a cleavable bond component. In yet another embodiment, any of the nanoparticles can comprise a buffering component, a degradable component, a hydrophilic component and a cleavable bond component. In some embodiments, the particle is composed of one or more polymers that contain any of the aforementioned combinations of components. 
     In further embodiments, the GPC2 targeting siRNA or dsRNA is conjugated to, complexed to, or encapsulated by the one or more lipids or polymers of the nanoparticle. GPC2 targeting dsRNAs or siRNAs can be encapsulated in the hollow core of a nanoparticle. Alternatively, or in addition, GPC2 targeting dsRNAs or siRNAs can be incorporated into the lipid or polymer based shell of the nanoparticle, for example via intercalation. Alternatively, or in addition, GPC2 targeting dsRNAs or siRNAs can be attached to the surface of the nanoparticle. In some embodiments, the GPC2 targeting siRNA or dsRNA is conjugated to one or more lipids or polymers of the nanoparticle, e.g. via covalent attachment. 
     In some embodiments, the nanoparticle further comprises a targeting agent. In some embodiments, the targeting agent comprises a peptide ligand, a nucleotide ligand, a polysaccharide ligand, a fatty acid ligand, a lipid ligand, a small molecule ligand, an antibody, an antibody fragment, an antibody mimetic or an antibody mimetic fragment. In some embodiments, the polysaccharide ligand is hyaluronic acid (HA). In some embodiments, the targeting agent binds to the surface of a cell of the cancer of the subject. In some embodiments, the targeting agent is on the surface and/or within the nanoparticle. 
     In some embodiments, the targeting agent comprises hyaluronic acid (HA). HA binds to CD44, a transmembrane peptidoglycan expressed on the surface of many types of cancer cells. CD44 integrates cellular environmental cues with growth factors and cytokine signals, and plays a role in the progression of many cancers. Targeting of CD44+ cells by HA nanoparticles thus provides superior delivery and specificity of the compositions of the disclosure to cancer cells. 
     In some embodiments, the nanoparticle further comprises a blending polymer. In some embodiments, the blending polymer is a copolymer comprising a degradable component and hydrophilic component. In some embodiments, the degradable component of the blending polymer is a polyester, poly(ortho ester), poly(ethylene imine), poly(caprolactone), polyanhydride, poly(acrylic acid), polyglycolide or poly(urethane). In some embodiments, the degradable component of the blending polymer is poly(lactic acid) (PLA) or poly(lactic-co-glycolic acid) (PLGA). In some embodiments, the hydrophilic component of the blending polymer is a polyalkylene glycol or a polyalkylene oxide. In some embodiments, the polyalkylene glycol is polyethylene glycol (PEG). In other embodiments, the polyalkylene oxide is polyethylene oxide (PEO). 
     In some embodiments, the nanoparticle is a polymer based nanoparticle. Polymer based nanoparticles comprise one or more polymers. In some embodiments, the one or more polymers comprise a polyester, poly(ortho ester), poly(ethylene imine), poly(caprolactone), polyanhydride, poly(acrylic acid), polyglycolide or poly(urethane). In still other embodiments, the one or more polymers comprise poly(lactic acid) (PLA) or poly(lactic-co-glycolic acid) (PLGA). In some embodiments, the one or more polymers comprise poly(lactic-co-glycolic acid) (PLGA). In some embodiments, the one or more polymers comprise poly(lactic acid) (PLA). In some embodiments, the one or more polymers comprise polyalkylene glycol or a polyalkylene oxide. In some embodiments, the polyalkylene glycol is polyethylene glycol (PEG) or the polyalkylene oxide is polyethylene oxide (PEO). 
     In some embodiments, the nanoparticle comprising the GPC2 siRNA is a polymer based nanoparticle. In some embodiments, the polymer-based nanoparticle comprises poly(lactic-co-glycolic acid) PLGA polymers. In some embodiments, the PLGA nanoparticle further comprises a targeting agent, such as HA. 
     In some embodiments, the nanoparticle has an average characteristic dimension of less than about 500 nm, 400 nm, 300 nm, 250 nm, 200 nm, 180 nm, 150 nm, 120 nm, 100 nm, 90 nm, 80 nm, 70 nm, 60 nm, 50 nm, 40 nm, 30 nm or 20 nm. In other embodiments, the nanoparticle has an average characteristic dimension of 10 nm, 20 nm, 30 nm, 40 nm, 50 nm, 60 nm, 70 nm, 80 nm, 90 nm, 100 nm, 120 nm, 150 nm, 180 nm, 200 nm, 250 nm or 300 nm. In further embodiments, the nanoparticle has an average characteristic dimension of 10-500 nm, 10-400 nm, 10-300 nm, 10-250 nm, 10-200 nm, 10-150 nm, 10-100 nm, 10-75 nm, 10-50 nm, 50-500 nm, 50-400 nm, 50-300 nm, 50-200 nm, 50-150 nm, 50-100 nm, 50-75 nm, 100-500 nm, 100-400 nm, 100-300 nm, 100-250 nm, 100-200 nm, 100-150 nm, 150-500 nm, 150-400 nm, 150-300 nm, 150-250 nm, 150-200 nm, 200-500 nm, 200-400 nm, 200-300 nm, 200-250 nm, 200-500 nm, 200-400 nm or 200-300 nm. 
     In some embodiments, for example those embodiments where nanoparticles comprising GPC2-targeting siRNAs are administered with one or more additional cancer therapies, the nanoparticle can comprise at least one siRNA targeting GPC2 and one or more therapeutic or chemotherapeutic agents. For example, the nanoparticle comprises at least one siRNA targeting GPC2 and a platinum based antineoplastic agent, or a DNA alkylating agent, or a DNA intercalating agent, or a topoisomerase inhibitor. 
     Chemotherapeutic agents that can be incorporated into the nanoparticles described herein include, but are not limited to, Cisplatin, Carboplatin, Doxorubicin, Cyclophosphamide, Etoposide, and Topotecan. 
     Therapeutic Agents 
     Provided herein are therapeutic agents, such as chemotherapeutic agents, which can be administered with the nanoparticles comprising siRNAs targeting GPC2 described herein. 
     In some embodiments, the additional therapeutic agent is incorporated into a nanoparticle comprising at least one siRNA targeting GPC2. In some embodiments, the additional therapeutic agent is conjugated to, complexed to, or encapsulated by the one or more lipids or polymers of the nanoparticle. Additional therapeutic agents can be encapsulated in the hollow core of a nanoparticle. Alternatively, or in addition, Additional therapeutic agents can be incorporated into the lipid or polymer based shell of the nanoparticle, for example via intercalation. Alternatively, or in addition, additional therapeutic agents can be attached to the surface of the nanoparticle. In some embodiments, the additional therapeutic agents are conjugated to one or more lipids or polymers of the nanoparticle, e.g. via covalent attachment. 
     In some embodiments, the additional therapeutic agent and the nanoparticles comprising siRNAs targeting GPC2 are formulated in the same composition. For example the nanoparticles comprising siRNAs targeting GPC2 and the additional therapeutic agent can be formulated in the same pharmaceutical composition. 
     In some embodiments, the additional therapeutic agent and the nanoparticles comprising siRNAs targeting GPC2 are formulated as separate compositions, e.g. for separate administration to a subject. 
     In some embodiments, the additional therapeutic agent is a chemotherapeutic agent. In some embodiments, the chemotherapeutic agent comprises a platinum based antineoplastic agent, a DNA alkylating agent, a DNA intercalating agent, or a topoisomerase inhibitor. 
     In some embodiments, the chemotherapeutic agent may comprise platinum based antineoplastic drug (platins). One mechanism of action by which platins work is through the crosslinking of DNA, which inhibits DNA repair, DNA synthesis, or both in cancer cells. Exemplary, but not limiting platins comprise Cisplatin or Carboplatin, and analogs or derivatives thereof. 
     In some embodiments, the chemotherapeutic agent may comprise a Topoisomerase I inhibitor or Topoisomerase II. Topoisomerase I and II are enzymes which regulates DNA structure by breaking and rejoining the phosphodiester backbone of the DNA during the cell cycle (e.g., during DNA synthesis). Without functional Topoisomerase I or II, single and double strand breaks accumulate, leading to cell death. Exemplary but not limiting Topoisomerase I inhibitors comprise Irinotecan, Topotecan, and analogs or derivatives thereof. Exemplary but not limiting Topoisomerase II inhibitors comprise Etoposide and analogs or derivatives thereof. 
     In some embodiments, the chemotherapeutic agent may comprise a DNA alkylating agent. DNA alkylating agents attach an alkyl group to DNA, typically to the guanine base of the DNA. This causes DNA damage, and may kill the cancer cells or stop them from dividing. In some embodiments, the DNA alkylating agent comprises Dacarbazine, Temozolomide, Cyclophosphamide or Ifosfamide and analogs or derivatives thereof. 
     In some embodiments, the chemotherapeutic agent may comprise a DNA intercalating agent. DNA intercalating agents insert themselves into the structure of the DNA within a cell and bind to the DNA, causing DNA damage. This may kill cancer cells, or stop them from dividing. Exemplary but not limiting DNA intercalating agents comprise Doxorubicin and analogs or derivatives thereof. 
     In some embodiments, the chemotherapeutic agent may comprise a taxane. Taxanes are a class of diterpenes that have long been used in cancer treatment. Taxanes act by disrupting microtubule function, which in turn disrupts cell division. Typically, taxanes act by stabilizing GDP bound tubulin in the microtubule, disrupting microtubule depolymerization and dynamic instability of microtubules. Exemplary taxanes comprise Paclitaxel or Docetaxel, and analogs or derivatives thereof. 
     In some embodiments, the chemotherapeutic agent may comprise a  Vinca  alkaloid. Like taxanes,  Vinca  alkaloids also act upon tubulin.  Vinca  alkaloids prevent microtubule polymerization, thus preventing cell division. Exemplary but not limiting  Vinca  alkaloids comprise Vinblastine, Vincristine, Vinorelbine, Vincaminol, Vineridine, Vinburnine, Vindesine, Vincamine and analogs or derivatives thereof. 
     In some embodiments, the chemotherapeutic agent may comprise a thymidylate synthase inhibitor. Thymidylate synthase is a key enzyme involved in DNA synthesis. Exemplary but not limiting thymidylate synthase inhibitors comprise 5-Fluorouracil and analogs or derivatives thereof. 
     Additional chemotherapeutic agents that cause DNA damage, such as through the binding of DNA or interfering with DNA synthesis, are also considered as within the scope of the invention. 
     Pharmaceutical Compositions 
     Provided herein are pharmaceutical compositions comprising nanoparticles, the nanoparticles comprising dsRNAs targeting GPC2 as described herein. 
     Provided herein are pharmaceutical compositions comprising the nanoparticles comprising siRNAs targeting GPC2 as described herein. 
     The pharmaceutical compositions of the disclosure can optionally comprise therapeutic agents, pharmaceutical agents, carriers, adjuvants, dispersing agents, diluents, and the like. 
     In some embodiments, the pharmaceutical composition comprises a therapeutic agent, such as a chemotherapeutic agent. In some embodiments, the therapeutic agent is formulated in the same nanoparticle as the dsRNA or siRNA targeting GPC2. 
     In some embodiments, the therapeutic agent is not formulated in the nanoparticle comprising the dsRNA or siRNA targeting GPC2, but both the nanoparticle and the therapeutic agent are formulated in the same pharmaceutical composition. In some embodiments, the therapeutic agent is not formulated in the nanoparticle comprising the dsRNA or siRNA targeting GPC2, and the nanoparticle and therapeutic agent are formulated in separate pharmaceutical compositions. 
     Pharmaceutical compositions can contain any of the reagents discussed above, and one or more of a pharmaceutically acceptable carrier, a diluent or an excipient. 
     A “pharmaceutical composition” is a formulation comprising the nanoparticles described herein, in a form suitable for administration to a subject. In one embodiment, the pharmaceutical composition is in bulk or in unit dosage form. The unit dosage form is any of a variety of forms, including, for example, a capsule, an IV bag, a tablet, a single pump on an aerosol inhaler or a vial. The quantity of active ingredient (e.g., a formulation of the disclosed agent) in a unit dose of composition is an effective amount and is varied according to the particular treatment involved. One skilled in the art will appreciate that it is sometimes necessary to make routine variations to the dosage depending on the age and condition of the patient. The dosage will also depend on the route of administration. A variety of routes are contemplated, including oral, pulmonary, rectal, parenteral, transdermal, subcutaneous, intravenous, intramuscular, intraperitoneal, inhalational, buccal, sublingual, intrapleural, intrathecal, intranasal, and the like. Dosage forms for the topical or transdermal administration of a of this invention include powders, sprays, ointments, pastes, creams, lotions, gels, solutions, patches and inhalants. In one embodiment, the active agent is mixed under sterile conditions with a pharmaceutically acceptable carrier, and with any preservatives, buffers, or propellants that are required. 
     As used herein, the phrase “pharmaceutically acceptable” refers to those compounds, anions, cations, materials, compositions, carriers, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio. 
     “Pharmaceutically acceptable excipient” means an excipient that is useful in preparing a pharmaceutical composition that is generally safe, non-toxic and neither biologically nor otherwise undesirable, and includes excipient that is acceptable for veterinary use as well as human pharmaceutical use. A “pharmaceutically acceptable excipient” as used in the specification and claims includes both one and more than one such excipient. 
     A pharmaceutical composition of the invention is formulated to be compatible with its intended route of administration. Examples of routes of administration include parenteral, e.g., intravenous, intradermal, subcutaneous, oral (e.g., inhalation), transdermal (topical), intraperitoneal (into the body cavity) and transmucosal administration. Solutions or suspensions used for parenteral, intradermal, intraperitoneal or subcutaneous application can include the following components: a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerine, propylene glycol or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl parabens; antioxidants such as ascorbic acid or sodium bisulfite; chelating agents such as ethylenediaminetetraacetic acid; buffers such as acetates, citrates or phosphates, and agents for the adjustment of tonicity such as sodium chloride or dextrose. The pH can be adjusted with acids or bases, such as hydrochloric acid or sodium hydroxide. The parenteral preparation can be enclosed in ampoules, disposable syringes or multiple dose vials made of glass or plastic. These preparations can contain antioxidants, buffers, bacteriostats and solutes which render the formulation isotonic with the blood of the intended recipient. Aqueous and non-aqueous sterile suspensions can include suspending agents and thickening agents. The formulations can be presented in unit/dose or multi-dose containers, for example sealed ampoules and vials, and can be stored in a freeze-dried (lyophilized) condition requiring only the addition of the sterile liquid carrier, for example, saline or water-for-injection immediately prior to use. 
     The pharmaceutical compositions containing the nanoparticles described herein may be manufactured in a manner that is generally known, e.g., by means of conventional mixing, dissolving, granulating, dragee-making, levigating, emulsifying, encapsulating, entrapping, or lyophilizing processes. Pharmaceutical compositions may be formulated in a conventional manner using one or more pharmaceutically acceptable carriers comprising excipients and/or auxiliaries that facilitate processing of the active agents into preparations that can be used pharmaceutically. Of course, the appropriate formulation is dependent upon the route of administration chosen. 
     Pharmaceutical compositions suitable for injectable use include sterile aqueous solutions (where water soluble) or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersion. For intravenous administration, suitable carriers include physiological saline, bacteriostatic water, Cremophor EL™ (BASF, Parsippany, N.J.) or phosphate buffered saline (PBS). In all cases, the composition must be sterile and should be fluid to the extent that easy syringeability exists. It must be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacteria and fungi. The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), and suitable mixtures thereof. The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required nanoparticle size in the case of dispersion and by the use of surfactants. Prevention of the action of microorganisms can be achieved by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, ascorbic acid, thimerosal, and the like. In many cases, it will be preferable to include isotonic agents, for example, sugars, polyalcohols such as manitol and sorbitol, and sodium chloride in the composition. Prolonged absorption of the injectable compositions can be brought about by including in the composition an agent which delays absorption, for example, aluminum monostearate and gelatin. 
     Oral compositions generally include an inert diluent or an edible pharmaceutically acceptable carrier. They can be enclosed in gelatin capsules or compressed into tablets. For the purpose of oral therapeutic administration, the active age can be incorporated with excipients and used in the form of tablets, troches, or capsules. Oral compositions can also be prepared using a fluid carrier for use as a mouthwash, wherein the agents in the fluid carrier is applied orally and swished and expectorated or swallowed. Pharmaceutically compatible binding agents, and/or adjuvant materials can be included as part of the composition. The tablets, pills, capsules, troches and the like can contain any of the following ingredients, or agents of a similar nature: a binder such as microcrystalline cellulose, gum tragacanth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, or corn starch; a lubricant such as magnesium stearate or Sterotes; a glidant such as colloidal silicon dioxide; a sweetening agent such as sucrose or saccharin; or a flavoring agent such as peppermint, methyl salicylate, or orange flavoring. 
     For administration by inhalation, the agents are delivered in the form of an aerosol spray from pressured container or dispenser, which contains a suitable propellant, e.g., a gas such as carbon dioxide, or a nebulizer. 
     The nanoparticles comprising dsRNAs or siRNAs can be prepared with pharmaceutically acceptable carriers that will protect the dsRNAs or siRNAs against rapid elimination from the body, such as a controlled release formulation, including implants and microencapsulated delivery systems. Biodegradable, biocompatible polymers can be used, such as ethylene vinyl acetate, polyanhydrides, polyglycolic acid, collagen, polyorthoesters, and polylactic acid. Methods for preparation of such formulations will be apparent to those skilled in the art, and the materials can be obtained commercially. Liposomal suspensions (including liposomes targeted to infected cells with monoclonal antibodies to viral antigens) can also be used as pharmaceutically acceptable carriers. These can be prepared according to methods known to those skilled in the art, for example, as described in U.S. Pat. No. 4,522,811. 
     It is especially advantageous to formulate oral or parenteral compositions in dosage unit form for ease of administration and uniformity of dosage. Dosage unit form as used herein refers to physically discrete units suited as unitary dosages for the subject to be treated; each unit containing a predetermined quantity of active agent calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier. The specification for the dosage unit forms of the invention are dictated by and directly dependent on the unique characteristics of the active agent and the particular therapeutic effect to be achieved. 
     The pharmaceutical compositions can be included in a container, pack, or dispenser together with instructions for administration. 
     As used herein, “pharmaceutically acceptable salts” refer to derivatives of the compounds of the present invention wherein the parent compound is modified by making acid or base salts thereof. Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines, alkali or organic salts of acidic residues such as carboxylic acids, and the like. The pharmaceutically acceptable salts include the conventional non-toxic salts or the quaternary ammonium salts of the parent compound formed, for example, from non-toxic inorganic or organic acids. 
     Techniques for formulation and administration of the disclosed compositions of the invention can be found in Remington: the Science and Practice of Pharmacy, 19th edition, Mack Publishing Co., Easton, Pa. (1995). 
     All percentages and ratios used herein, unless otherwise indicated, are by weight. Other features and advantages of the present invention are apparent from the different examples. The provided examples illustrate different components and methodology useful in practicing the present invention. The examples do not limit the claimed invention. Based on the present disclosure the skilled artisan can identify and employ other components and methodology useful for practicing the present invention. 
     Nucleic Acids and Vectors 
     The disclosure provides nucleic acids comprising the sequences encoding the dsRNAs or siRNAs targeting GPC2 described herein. 
     In some embodiments, the nucleic acids are ribonucleic acids (RNAs). 
     In some embodiments, the nucleic acids are deoxyribonucleic acids (DNAs). The DNAs may be a vector or a plasmid, e.g., an expression vector. 
     A “vector” is any nucleic acid molecule for the cloning of and/or transfer of a nucleic acid into a cell. A vector may be a replicon to which another nucleotide sequence may be attached to allow for replication of the attached nucleotide sequence. A “replicon” can be any genetic element (e.g., plasmid, phage, cosmid, chromosome, viral genome) that functions as an autonomous unit of nucleic acid replication in vivo, i.e., capable of replication under its own control. The term “vector” includes both viral and nonviral (e.g., plasmid) nucleic acid molecules for introducing a nucleic acid into a cell in vitro, ex vivo, and/or in vivo. A large number of vectors known in the art may be used to manipulate nucleic acids, incorporate response elements and promoters into genes, etc. For example, the insertion of the nucleic acid fragments corresponding to response elements and promoters into a suitable vector can be accomplished by ligating the appropriate nucleic acid fragments into a chosen vector that has complementary cohesive termini. Alternatively, the ends of the nucleic acid molecules may be enzymatically modified or any site may be produced by ligating nucleotide sequences (linkers) to the nucleic acid termini Such vectors may be engineered to contain sequences encoding selectable markers that provide for the selection of cells that contain the vector and/or have incorporated the nucleic acid of the vector into the cellular genome. Such markers allow identification and/or selection of host cells that incorporate and express the proteins encoded by the marker. A “recombinant” vector refers to a viral or non-viral vector that comprises one or more heterologous nucleotide sequences (i.e., transgenes), e.g., two, three, four, five or more heterologous nucleotide sequences. 
     By the term “express” or “expression” of a polynucleotide coding sequence, it is meant that the sequence is transcribed, and optionally, translated. Typically, according to the present invention, expression of a coding sequence of the invention will result in production of the polypeptide of the invention. The entire expressed polypeptide or fragment can also function in intact cells without purification. 
     In some embodiments, the vector is an expression vector for manufacturing siRNAs of the disclosure. Exemplary expression vectors may comprise a sequence encoding the sense and/or anti-sense strand of the siRNA under the control of a suitable promoter for transcription. Interfering RNAs may be expressed from a variety of eukaryotic promoters known to those of ordinary skill in the art, including pol III promoters, such as the U6 or H1 promoters, or pol II promoters, such as the cytomegalovirus promoter. Those of skill in the art will recognize that these promoters can also be adapted to allow inducible expression of the interfering RNA. 
     dsRNAs and siRNAs can be expressed endogenously from plasmid or viral expression vectors, or from minimal expression cassettes, for example, PCR generated fragments comprising one or more promoters and an appropriate template or templates for transcribing the siRNA. Examples of commercially available plasmid-based expression vectors for shRNA include members of the pSilencer series (Ambion, Austin. Tex.) and pCpG-siRNA (InvivoGen. San Diego, Calif.). Examples of kits for production of PCR-generated shRNA expression cassettes include Silencer Express (Ambion, Austin, Tex.) and siXpress (Minis, Madison. Wis.). 
     Viral vectors for the in vivo expression of siRNAs and dsRNAs in eukaryotic cells are also contemplated as within the scope of the instant disclosure. Viral vectors may be derived from a variety of viruses including adenovirus, adeno-associated virus, lentivirus (e.g., HIV, FIV, and EIAV), and herpes virus. Examples of commercially available viral vectors for shRNA expression include pSilencer adeno (Ambion, Austin, Tex.) and pLenti6/BLOCK-iT™-DEST (Invitrogen, Carlsbad, Calif.). Selection of viral vectors, methods for expressing the siRNA from the vector and methods of delivering the viral vector, for example incorporated within a nanoparticle, are within the ordinary skill of one in the art. 
     It will be apparent to those skilled in the art that any suitable vector, optionally incorporated into a nanoparticle, can be used to deliver the dsRNAs or siRNAs described herein to a cell or subject. The vector can be delivered to cells in vivo. In other embodiments, the vector can be delivered to cells ex vivo, and then cells containing the vector are delivered to the subject. The choice of delivery vector can be made based on a number of factors known in the art, including age and species of the target host, in vitro versus in vivo delivery, level and persistence of expression desired, intended purpose (e.g., for therapy or screening), the target cell or organ, route of delivery, size of the isolated polynucleotide, safety concerns, and the like. 
     Methods of Making dsRNAs 
     Provided herein are methods of making dsRNAs or siRNAs targeting GPC2, and nanoparticles comprising same. 
     siRNAs may be generated exogenously by chemical synthesis, by in vitro transcription, or by cleavage of longer double-stranded RNA with Dicer or another appropriate nuclease with similar activity. Chemically synthesized siRNAs, produced from protected ribonucleoside phosphoramidites using a conventional DNA/RNA synthesizer, may be obtained from commercial suppliers such as Millipore Sigma (Houston, Tex.), Ambion Inc. (Austin, Tex.). Invitrogen (Carlsbad, Calif.), or Dharmacon (Lafayette, Colo.). siRNAs can be purified by extraction with a solvent or resin, precipitation, electrophoresis, chromatography, or a combination thereof, for example. Alternatively, siRNAs may be used with little if any purification to avoid losses due to sample processing. 
     In alternative embodiments, dsRNAs and siRNAs can be produced using an expression vector into which a nucleic acid encoding the double stranded RNA has been cloned, for example under control of a suitable promoter. 
     In some embodiments, dsRNAs or siRNAs can be incorporated in a nanoparticle. 
     Nanoparticles comprising dsRNAs or siRNAs of the disclosure can be prepared by any suitable means known in the art. For example, polymeric nanoparticles can be prepared using various methods including, but not limited to, solvent evaporation, spontaneous emulsification, solvent diffusion, desolvation, dialysis, ionic gelation, nanoprecipitation, salting out, spray drying and supercritical fluid methods. The dispersion of preformed polymers and the polymerization of monomers are two additional strategies for preparation of polymeric nanoparticles. However, the choice of an appropriate method depends upon various factors, which will be known to the person of ordinary skill in the art. 
     Sterile injectable solutions comprising a nanoparticle of the disclosure can be prepared by incorporating the GPC2-targeting siRNA in the nanoparticles in the required amount in an appropriate solvent with one or a combination of ingredients enumerated herein, as required, followed by filtered sterilization. Alternatively, or in addition, sterilization can be achieved through other means such as radiation or gas. Generally, dispersions are prepared by incorporating the nanoparticles into a sterile vehicle that contains a basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, methods of preparation are vacuum drying and freeze drying that yields a powder of GPC2 siRNA nanoparticles plus any additional desired ingredient from a previously sterile filtered solution thereof. 
     Inhibition of GPC2 Expression 
     Provided herein are methods of reducing or inhibiting GPC2 expression or activity in a cell, comprising contacting the cell with an siRNA targeting GPC2 as described herein. siRNAs of the disclosure that target GPC2 can reduce or inhibit GPC2 activity through the RNAi pathway. The cell can be in vitro, in vivo or ex vivo. For example, the cell can be from a cell line, or in vivo in a cancer patient. 
     In some embodiments, siRNAs of the disclosure are capable of inducing RNAi-mediated degradation of a GPC2 mRNA in a cancer cell of a subject. 
     In some embodiments, administration of nanoparticles comprising siRNAs targeting GPC2 or pharmaceutical compositions comprising same decreases viability of a cell of the cancer. 
     In some embodiments, administration of nanoparticles comprising siRNAs targeting GPC2 or pharmaceutical compositions comprising same increases apoptosis of cells. 
     As used herein, the terms “contacting,” “introducing” and “administering” are used interchangeably, and refer to a process by which dsRNA or siRNA of the present disclosure or a nucleic acid molecule encoding a dsRNA or siRNA of this disclosure is delivered to a cell, in order to inhibit or alter or modify expression of a target gene. The dsRNA may be administered in a number of ways, including, but not limited to, direct introduction into a cell (i.e., intracellularly) and/or extracellular introduction into a cavity, interstitial space, or into the circulation of the organism. 
     “Introducing” in the context of a cell or organism means presenting the nucleic acid molecule to the organism and/or cell in such a manner that the nucleic acid molecule gains access to the interior of a cell. Where more than one nucleic acid molecule is to be introduced these nucleic acid molecules can be assembled as part of a single polynucleotide or nucleic acid construct, or as separate polynucleotide or nucleic acid constructs, and can be located on the same or different nucleic acid constructs. Accordingly, these polynucleotides can be introduced into cells in a single transformation event or in separate transformation events. Thus, the term “transformation” as used herein refers to the introduction of a heterologous nucleic acid into a cell. Transformation of a cell may be stable or transient. 
     The term “inhibit” or “reduce” or grammatical variations thereof, as used herein, refer to a decrease or diminishment in the specified level or activity of at least about 5%, about 10%, about 15%, about 25%, about 35%, about 40%, about 50%, about 60%, about 75%, about 80%, about 90%, about 95% or more. In some embodiments, the inhibition or reduction results in little or essentially no detectible activity (at most, an insignificant amount, e.g., less than about 10% or even 5%). 
     In contrast, the term “increase” or grammatical variations thereof as used herein refers to an increase or elevation in the specified level or activity of at least about 5%, about 10%, about 15%, about 25%, about 35%, about 40%, about 50%, about 60%, about 75%, about 80%, about 90%, about 95% or more. Increases in activity can be described in terms of fold change. For example, activity can be increased 1.2×, 1.5×, 2×, 3×, 5×, 6×, 7×, 8×, 9×, 10× or more compared to a baseline level of activity. 
     As used herein, the term “IC50” or “IC 50  value” refers to the concentration of an agent where cell viability is reduced by half. The IC 50  is thus a measure of the effectiveness of an agent in inhibiting a biological process. In an exemplary model, cancerous cell lines are cultured using standard techniques, treated with a GPC2 siRNA and the IC 50  value of the GPC2 siRNA is calculated after 24, 48 and/or 72 hours to determine its effectiveness in killing the cancer cells or inhibiting cell growth. 
     Methods of monitoring of GPC2 mRNA and/or protein expression can be used to characterize gene silencing, and to determine the effectiveness of the compositions described herein. Expression of GPC2 may be evaluated by any known technique. Examples thereof include immunoprecipitations methods, utilizing GPC2 antibodies in assays such as ELISAs, Western Blot, or immunohistochemistry to visualize GPC2 protein expression in cells, or flow cytometry. Additional methods include various hybridization methods utilizing a nucleic acid that specifically hybridizes with a nucleic acid encoding GPC2 or a unique fragment thereof, or a transcription product (e.g., mRNA) or splicing product of said nucleic acid, Northern Blot methods, Southern blot methods, and various PCR-based methods such as RT-PCR, qPCR or digital droplet PCR. GPC2 mRNA expression may additionally be assessed using high throughput sequencing techniques. Using high throughput sequencing of RNA libraries, the level of GPC2 mRNA from a sample of cells can be calculated from the number of reads that map to a GPC2 reference sequence using techniques known in the art. GPC2 expression can be assayed in cultured cells, spheroid bodies, patient derived xenograft cancer models, or patient samples. 
     Methods of assaying the effect of individual dsRNAs or siRNAs on tumor cells include transfecting representative cell lines with dsRNAs or siRNAs targeting GPC2, and measuring viability. For example, cells from representative cell lines can be transfected using methods known in the art, such as the RNAiMAX Lipofectamine kit (Invitrogen, Carlsbad, Calif.), and cultured using any suitable technique known in the art. Optionally additional therapeutic agents as described herein can be added at variable concentrations to cell culture media following transfection. Following a suitable incubation period, such as 24-96 hours, cell viability can be measured using methods such as Cell Titer Glo 2.0 (Promega, CA) to determine cell viability, and/or GPC2 mRNA and protein levels can be assessed using the methods described herein. 
     Treatment of Cancer 
     Provided herein are methods of treating a cancer in a subject, comprising administering to the subject a therapeutically effective amount of a nanoparticle comprising a dsRNA or siRNA targeting GPC2. In some embodiments, the methods comprise administering a chemotherapeutic agent to the subject. The chemotherapeutic agent can be formulated in the nanoparticles, in the same pharmaceutical composition as the nanoparticles, or in a separate composition. In some embodiments, the chemotherapeutic agent comprises a platinum based antineoplastic agent, a DNA alkylating agent, a DNA intercalating agent, or a topoisomerase inhibitor as described herein. 
     In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of a composition comprising a nanoparticle, the nanoparticle comprising a small interfering RNA (siRNA), wherein the siRNA comprises a sense region and anti-sense region complementary to the sense region that together form an RNA duplex, wherein the sense region comprises a sequence at least 70% identical to a glypican-2 (GPC2) mRNA sequence of SEQ ID NO: 1 or SEQ ID NO: 2. 
     Suitable subjects include mammals. The term “mammal” as used herein includes, but is not limited to, humans, bovines, ovines, caprines, equines, felines, canines, lagomorphs, etc. Human subjects include neonates, infants, juveniles, and adults. In some embodiments, the subject is an animal model of cancer, for example a mouse or a rat model of cancer. In certain embodiments, the subject has or is at risk for cancer. 
     In some embodiments, the cancer is a cancer that expresses GPC2 on the cells of the cancer. 
     In some embodiments, the cancer is selected from the group consisting of astrocytoma, breast cancer, colorectal cancer, Ewing&#39;s sarcoma, gastric cancer, leiomyosarcoma, liver cancer, lung cancer, mesothelioma, ovarian cancer, pancreatic cancer, renal cancer, rhabdomyosarcoma and neuroblastoma. 
     In some embodiments, the cancer is astrocytoma. Astrocytomas are a type of cancer of the brain. Astrocytomas originate from a type of glial cells, star-shaped brain cells in the cerebrum called astrocytes. This type of tumor does not usually spread outside the brain and spinal cord. 
     In some embodiments, the cancer is breast cancer. Breast cancers are cancers that arise from cells in the breast. Breast cancers can occur in both men and women. Exemplary types of breast cancer include ductal carcinoma in situ, invasive breast cancers such as invasive ductal carcinoma and invasive lobular carcinoma, and inflammatory breast cancer. 
     In some embodiments, the cancer is colorectal cancer. Colorectal cancers comprise cancers of the colon or rectum. The rectum is the passageway that connects the colon to the anus. In certain embodiments, the colorectal cancer comprises a colorectal carcinoma. 
     In some embodiments, the cancer is Ewing&#39;s sarcoma. Ewing&#39;s sarcoma comprises tumors of the bones, the soft tissue surrounding bones such as cartilage and nerves, or a combination thereof. Ewing&#39;s sarcoma typically affects children and young adults, although it can occur at any age. Ewing&#39;s sarcoma can occur in any bone. In some more frequent embodiments, Ewing&#39;s sarcoma begins in the leg bones, hipbones, arm bones, and bones in the chest, skull or spine. In some less common embodiments, Ewing&#39;s sarcoma occurs in the soft tissues of the arms, legs, abdomen, chest, neck, head or a combination thereof. In some embodiments of Ewing&#39;s sarcoma, there is no bone involvement. In some embodiments, treatments for Ewing&#39;s sarcoma comprise chemotherapy, surgery, or a combination thereof. In some embodiments, Ewing&#39;s sarcoma is associated with a chromosomal translocations affecting the EWSR1 (EWS RNA binding protein 1), FLI1 (Fli-1 proto-oncogene), ERG (ERG, ETS transcription factor) and ETV1 (ETS variant 1) genes. 
     In some embodiments, the cancer is gastric cancer. Gastric cancers comprise cancers which form from the cells of the lining of the stomach. In some embodiments, the gastric cancer comprises a gastrointestinal stromal cell tumor (GIST), a lymphoma, a carcinoid tumor, a squamous cell carcinoma, a small cell carcinoma or a leiomyosarcoma. GISTs may be malignant or benign. GISTs are most commonly found in the stomach and small intestine, but may be found anywhere in in or near the gastrointestinal tract. In some embodiments, a GIST may arise from the interstitial cells of Cajal. A lymphoma is a cancer of the lymph nodes and lymphatic system. A gastric lymphoma may be a primary lymphoma (i.e., a lymphoma that originates in the stomach itself), or a secondary lymphoma that originated elsewhere and metastasized to the stomach. Gastric squamous cell carcinomas are extremely rare. Squamous cell carcinomas arise from abnormal squamous cells, which are cells in the upper layer of the skin. Small cell carcinomas are a highly malignant type of cancer that most frequently occur in the lungs, but can arise in the cervix, prostate, liver pancreas, gastrointestinal tract or bladder. 
     In some embodiments, the cancer is Leiomyosarcoma. Leiomyosarcomas are a type of soft tissue sarcoma. In some embodiments, the leiomyosarcoma comprises a malignant tumor that arises from smooth muscle cells. Smooth muscles cells are the cells of involuntary muscles, i.e. muscles over which the brain has no voluntary control. Exemplary involuntary muscles comprise the walls of the digestive tract and muscles controlling salivary gland secretions. In some embodiments, the leiomyosarcoma grows and spreads into surrounding tissues. In some embodiments, the leiomyosarcoma spreads to distant sites of the body via the bloodstream or lymphatic system, or both. In some embodiments, a leiomyosarcoma can form almost anywhere where there are blood vessels, such as the heart, liver, pancreas, genitourinary and gastrointestinal tract, the space behind the abdominal cavity (retroperitoneum), the uterus or skin. In some of the more common embodiments, the leiomyosarcoma forms in the uterus. Symptoms, diagnosis and treatment of leiomyosarcomas varies depending on the location and stage of the cancer. 
     In some embodiments, the cancer is liver cancer. Liver cancers comprise cancers that form from cells of the liver. Exemplary but non-limiting liver cancers include hepatocellular carcinoma, cholangiocarcinoma and hepatoblastoma. In some embodiments, the liver cancer comprises a hepatocellular carcinoma. In some embodiments, the hepatocellular carcinoma occurs in a patient with chronic liver disease and cirrhosis. In some embodiments, the hepatocellular carcinoma forms from hepatic stem cells. In some embodiments, the liver cancer comprises a cholangiocarcinoma. In some embodiments, the cholangiocarcinoma forms in the bile ducts just outside the liver. In some embodiments, the cholangiocarcinoma is intrahepatic, extrahepatic (i.e., perihilar) or a distal extrahepatic cholangiocarcinoma. In some embodiments, the liver cancer comprises a hepatoblastoma. In some embodiments, the hepatoblastoma occurs in a child or an infant. In some embodiments, the hepatoblastoma originates from immature liver precursor cells. In some embodiments, the hepatoblastoma originates from pluripotent stem cells. In some embodiments, risk factors for liver cancer include obesity, diet, smoking, and genetic factors. 
     In some embodiments, the cancer is lung cancer. In some embodiments, the lung cancer is a small cell lung cancer. In some embodiments, the small cell lung cancer is a small cell carcinoma (oat cell cancer) or a combined small cell carcinoma. In some embodiments, the small cell carcinoma comprises a neuroendocrine subtype of lung cancer that likely arises from neuroendocrine cells in the lung. Risk factors include asbestos exposure and smoking. In some embodiments, the lung cancer is a non-small cell lung cancer. In some embodiments, the non-small cell lung cancer is a non-small cell lung carcinoma. In some embodiments, the non-small cell lung carcinoma is an epithelial lung cancer other than small cell lung carcinoma. In some embodiments the non-small cell lung cancer is an adenocarcinoma, a squamous cell (epidermoid) carcinoma, an adenosquamous carcinoma or a sarcomatoid carcinoma. Squamous cells are flat cells that line the insides of the airways in the lungs. 
     In some embodiments, the cancer is mesothelioma. Mesotheliomas comprise cancers that develop from the mesothelial, a thin layer of tissue lining lungs, abdomen or heart. In some embodiments, mesotheliomas affect the pleura that surrounds the lungs (pleural mesothelioma). In some embodiments, mesotheliomas affect the tissue of the abdomen (peritoneal mesothelioma). Risk factors for mesothelioma comprise asbestos exposure. 
     In some embodiments, the cancer is ovarian cancer. Ovarian cancers are cancers arising from cells of the ovaries. Ovarian cancers include, but are not limited to, ovarian epithelial cancers, germ cell tumors, ovarian carcinomas, ovarian stromal tumors and ovarian sarcoma. 
     In some embodiments, the cancer is pancreatic cancer. Pancreatic cancers typically arise from the cells in the pancreas, a glandular organ behind the stomach. In some, more frequent, embodiments, the pancreatic cancer is a pancreatic adenocarcinoma. Typically, pancreatic adenocarcinomas arise from the part of the pancreas which makes digestive enzymes. In some embodiments, the pancreatic cancer is a neuroendocrine tumor, which arises from the hormone producing cells of the pancreas. 
     In some embodiments, the cancer is renal cancer. Renal cancers are cancers that arise from cells of the kidney. In some embodiments, the renal cancer first appears in the tubules of the kidney. In some embodiments, the renal cancer is an adult cancer. In some embodiments, the renal cancer is a pediatric cancer. In some embodiments, the renal cancer is a renal cell carcinoma, an inherited papillary renal cell carcinoma, a urothelial cell carcinoma of the renal pelvis, a squamous cell carcinoma, a juxtaglomerular cell tumor (reninoma), an angiomyolipoma, a renal oncocytoma, a Bellini duct carcinoma, a clear-cell sarcoma of the kidney, a mesoblastic nephroma, a Wilms&#39; tumor (usually diagnosed in children under 5 years of age) or a mixed epithelial stromal tumor. 
     In some embodiments, the cancer is rhabdomyosarcoma. In some embodiments, the rhabdomyosarcoma comprises an embryonal rhabdomyosarcoma. Embryonal rhabdomyosarcomas typically affect children in their first five years of life. The cells of an embryonal rhabdomyosarcoma comprise cells that resemble the developing muscle cells of a six to eight week embryo. In some embodiments, embryonal rhabdomyosarcomas comprise rhabdomyosarcomas of the head and neck area, bladder vagina, or in or around the prostate and testicles. In some embodiments, embryonal rhabdomyosarcomas comprise botryoid and spindle rhabdomyosarcomas. In some embodiments, the rhabdomyosarcoma comprises an alveolar rhabdomyosarcoma. Alveolar rhabdomyosarcomas typically affect all age groups equally. Alveolar rhabdomyosarcomas typically occur in the large muscles of the trunk, arms and legs. The cells of an alveolar rhabdomyosarcoma comprise cells that resemble those of normal muscle cells seen in a ten week old fetus. In some embodiments, the rhabdomyosarcoma comprises an anaplastic rhabdomyosarcoma. 
     In some embodiments, the cancer is a neuroblastoma. In some embodiments, neuroblastomas are cancers that begin in certain forms of nerve cells typically found in an embryo or fetus. In some embodiments, the nerve cells that give rise to the neuroblastoma are neuroblasts. Neuroblastomas occur most frequently in infants and young children, and are found only rarely in subjects older than ten years of age. In some embodiments, the neuroblastoma starts in the adrenal gland. In some embodiments, the neuroblastoma starts in the sympathetic nerve ganglia in the abdomen. In some embodiments, the neuroblastoma starts in the sympathetic nerve ganglia near the spine in the chest, neck or pelvis. In some embodiments, the neuroblastoma is a ganglioneuroblastoma. In some embodiments, the ganglioneuroblastoma comprises both malignant and benign components. 
     In some embodiments of the methods of treating cancer of the disclosure, the compositions of the disclosure, e.g. comprising nanoparticles comprising dsRNAs or siRNAs targeting GPC2, can be administered as a monotherapy. 
     In other embodiments, the nanoparticles comprising dsRNAs or siRNAs targeting GPC2 are administered in conjunction with agents useful for treating cancer, such as chemotherapeutic agents, or standards of care for the cancer. In some embodiments, the nanoparticle compositions of the disclosure can be administered as a combination therapy, i.e. in conjunction with one or more additional therapeutic agents. For example, a composition comprising nanoparticles comprising siRNAs targeting GPC2 can be administered with a chemotherapeutic agent. The chemotherapeutic agent can be platinum based antineoplastic agent, a DNA alkylating agent, a DNA intercalating agent, or a topoisomerase inhibitor. In some embodiments, the chemotherapeutic agent is selected from the group consisting of Cisplatin, Carboplatin, Cyclophosphamide, Doxorubicin, Topotecan or Etoposide. 
     In some embodiments, administration of nanoparticles comprising siRNAs targeting GPC2 or pharmaceutical compositions comprising same increases sensitivity of the cancer to an additional chemotherapeutic agent. For example, administering nanoparticle compositions can increase sensitivity to the additional chemotherapeutic agent such as Cisplatin, Carboplatin, Cyclophosphamide, Doxorubicin, Topotecan or Etoposide, thereby lowering the therapeutically effective amount of the chemotherapeutic agent. Administering nanoparticles comprising dsRNAs or siRNAs targeting GPC2 can, in some embodiments, decrease the IC50 of chemotherapeutic agents (the half maximal inhibitory concentration). In some embodiments, administering nanoparticles comprising dsRNAs or siRNAs targeting GPC2 can decrease the IC50 of a chemotherapeutic agent by at least 1 fold, at least 2 fold, at least 3 fold, at least 4 fold, at least 5 fold, at least 6 fold, at least 7 fold, at least 8 fold, at least 9 fold, at least 10 fold, at least 15 fold, at least 20 fold, at least 25 fold, at least 30 fold, at least 35 fold, at least 40 fold, at least 45 fold, at least 50 fold, at least 55 fold, at least 60 fold, at least 65 fold, at least 70 fold, at least 75 fold, or at least 80 fold. In some embodiments, administering nanoparticles comprising dsRNAs or siRNAs targeting GPC2 can decrease the IC50 of a chemotherapeutic agent by between about 1 and 80 fold, 1 and 70 fold, 1 and 60 fold, 1 and 50 fold, 1 and 40 fold, 1 and 30 fold, 1 and 20 fold, 1 and 10 fold, 3 and 80 fold, 3 and 70 fold, 3 and 60 fold, 3 and 50 fold, 3 and 40 fold, 3 and 30 fold, 3 and 20 fold, 3 and 10 fold, 5 and 70 fold, 5 and 60 fold, 5 and 55 fold, 5 and 50 fold, 5 and 45 fold, 5 and 40 fold, 5 and 35 fold, 5 and 30 fold, 5 and 25 fold, 5 and 20 fold, 5 and 15 fold, 5 and 10 fold, 10 and 70 fold, 10 and 50 fold, 20 and 50 fold, 20 and 40 fold, or 20 and 30 fold. In some embodiments, administering nanoparticles comprising dsRNAs or siRNAs targeting GPC2 can decrease the IC50 of a chemotherapeutic agent by between about 3 and 70 fold. In some embodiments, administering nanoparticles comprising dsRNAs or siRNAs targeting GPC2 can decrease the IC50 of a chemotherapeutic agent by between about 5 and 50 fold. In some embodiments, administering nanoparticles comprising dsRNAs or siRNAs targeting GPC2 can decrease the IC50 of a chemotherapeutic agent by between about 10 and 30 fold. In some embodiments, administration of nanoparticle compositions increases the effectiveness of the chemotherapeutic agent in the treatment of cancer. In some embodiments, administration of nanoparticles comprising dsRNAs or siRNAs targeting GPC2 can reduce a side effect of the chemotherapeutic agent. For example, if the chemotherapeutic agent is more effective when GPC2 expression is reduced, a lower amount of the chemotherapeutic agent can be administered to the subject, thereby reducing side effects. In some embodiments, administration of nanoparticles comprising dsRNAs or siRNAs targeting GPC2 reduces a sign or a symptom of the cancer. 
     The nanoparticle compositions of the disclosure, and the one or more additional therapeutic agent(s) can be administered simultaneously. For example, the nanoparticles comprising dsRNAs or siRNAs targeting GPC2 and the additional therapeutic agents(s) can be formulated in the same pharmaceutical composition, and are administered simultaneously to a subject. As a further example, the nanoparticles comprising dsRNAs or siRNAs targeting GPC2 may further comprise one or more additional chemotherapeutic agents, and are administered simultaneously to a subject. 
     Alternatively, or in addition, the additional therapeutic agent(s) can formulated in separate pharmaceutical composition from the nanoparticles comprising siRNAs of the disclosure, and can be administered separately to a subject. For example, the nanoparticles of the disclosure and the one or more additional therapeutic agent(s) may be delivered via different routes of administration, or on different delivery schedules. 
     In some embodiments, the one or more additional therapeutic agents are delivered in temporal proximity with the nanoparticles comprising siRNAs of the disclosure. As used herein, “temporal proximity” means sufficiently close in time to produce a combined effect (that is, temporal proximity can be simultaneously, or it can be two or more events occurring within a short time period before or after each other). 
     The composition comprising nanoparticles comprising dsRNAs or siRNAs targeting GPC2 can be administered to a subject with a cancer. In some embodiments, the administration occurs once a month. In some embodiments, the administration occurs every two weeks. In some embodiments, the administration occurs once a week. In some embodiments, the administration occurs once a day. In some embodiments, the administration occurs twice a day. In some embodiments, the administration occurs three times a day. In some embodiments, the administration occurs four or more times a day. In some embodiments, the subject is administered a composition comprising a therapeutically effective amount of the composition for at least a week, at least a month, at least 2 months, at least 3 months, at least 4 months, at least 5 months, at least 6 months, at least 1 year, at least 2 years, at least 3 years or until the cancer is alleviated. 
     In some embodiments, the composition comprising nanoparticles comprising dsRNAs or siRNAs targeting GPC2 is administered daily, every day, without a holiday. In some embodiments, the composition comprising nanoparticles comprising dsRNAs or siRNAs targeting GPC2 is administered with a holiday. In some embodiments, this holiday is once a week. In some embodiments, this holiday is twice a week. In some embodiments, this holiday is once every other week. In some embodiments, this holiday is once a month. In some embodiments, this holiday is determined by the effectiveness of the composition comprising nanoparticles comprising dsRNAs or siRNAs targeting GPC2 in alleviating a sign or a symptom of the cancer, and/or how well the subject with the cancer tolerates the administration of the composition. 
     In some embodiments, the composition comprising nanoparticles comprising dsRNAs or siRNAs targeting GPC2, and optionally, a chemotherapeutic agent, is administered simultaneously with one or more additional cancer therapies. In some embodiments, the nanoparticle composition is administered before an additional cancer therapy. In some embodiments, the nanoparticle composition is administered after an additional cancer therapy. In some embodiments, the nanoparticle composition and the additional cancer therapy are administered in alternation. In some embodiments, this additional cancer therapy comprises an additional chemotherapy. 
     In some embodiments of the methods of treating cancer of the disclosure, the methods further comprise a standard of care for the cancer. A standard of care for a cancer is a generally accepted appropriate treatment for a given cancer indication based on scientific evidence, and represents the current consensus of the scientific and medical communities. Standards of care for cancers can include, but are not limited to, radiation treatment, surgery to resect tumors, either partially or fully, and additional cancer therapies such as combination therapies, small molecule inhibitors or immunotherapies. An appropriate standard of care for a cancer will be apparent to the person of ordinary skill in the art. 
     A cancer that is to be treated can be staged according to an American Joint Committee on Cancer (AJCC) classification as Stage I, Stage IIA, Stage IIB, Stage IIIA, Stage IIIB, Stage IIIC, or Stage IV. A cancer that is to be treated can be assigned a grade according to an AJCC classification as Grade GX (e.g., grade cannot be assessed), Grade 1, Grade 2, Grade 3 or Grade 4. A cancer that is to be treated can be staged according to an AJCC pathologic classification (pN) of pNX, pN0, PN0 (I−), PN0 (I+), PN0 (mol−), PN0 (mol+), PN1, PN1 (mi), PN1a, PN1b, PN1c, pN2, pN2a, pN2b, pN3, pN3a, pN3b, or pN3c. Alternatively, or in addition, a cancer can be staged according to the TNM staging system, which divides most types of cancers into 4 stages. Stage 1 usually means that a cancer is relatively small and contained within the organ of origin. Stage 2 cancers have usually not started to spread into surround tissues, but that the tumor is larger than stage 1. In some embodiments, stage 2 means that the cancer has spread into the lymph nodes close to the tumor. Stage 3 cancers are usually larger, and have started to spread into surrounding tissues and lymph nodes. Stage 4, or metastatic cancers, are typically cancers that have spread from the point of origin to other organ(s) in the body. 
     A cancer that is to be treated can be evaluated by DNA cytometry, flow cytometry, or image cytometry. A cancer that is to be treated can be typed as having 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90% of cells in the synthesis stage of cell division (e.g., in S phase of cell division). A cancer that is to be treated can be typed as having a low S-phase fraction or a high S-phase fraction. 
     As used herein, a “normal cell” is a cell that cannot be classified as part of a “cell proliferative disorder”. A normal cell lacks unregulated or abnormal growth, or both, that can lead to the development of an unwanted condition or disease. Preferably, a normal cell possesses normally functioning cell cycle checkpoint control mechanisms. 
     As used herein, “contacting a cell” refers to a condition in which a compound or other composition of matter is in direct contact with a cell, or is close enough to induce a desired biological effect in a cell. 
     As used herein, “monotherapy” refers to the administration of a single active or therapeutic agent to a subject in need thereof. Preferably, monotherapy will involve administration of a therapeutically effective amount of an active agent. For example, administering a nanoparticle comprising an siRNA targeting GPC2 to a subject in need of treatment of cancer. Monotherapy may be contrasted with combination therapy, in which a combination of multiple active agents is administered, preferably with each component of the combination present in a therapeutically effective amount. 
     As used herein, “treating” or “treat” describes the management and care of a subject for the purpose of combating a disease, condition, or disorder and includes the administration of a pharmaceutical composition of the disclosure to alleviate the symptoms or complications of cancer or to eliminate the cancer. 
     As used herein, the term “alleviate” is meant to describe a process by which the severity of a sign or symptom of cancer is decreased. Importantly, a sign or symptom can be alleviated without being eliminated. In a preferred embodiment, the administration of pharmaceutical compositions of the disclosure leads to the elimination of a sign or symptom, however, elimination is not required. Effective dosages are expected to decrease the severity of a sign or symptom. For instance, a sign or symptom of a disorder such as cancer, which can occur in multiple locations, is alleviated if the severity of the cancer is decreased within at least one of multiple locations. 
     As used herein, the term “severity” is meant to describe the potential of cancer to transform from a precancerous, or benign, state into a malignant state. Alternatively, or in addition, severity is meant to describe a cancer stage, for example, according to the TNM system (accepted by the International Union Against Cancer (UICC) and the American Joint Committee on Cancer (AJCC)) or by other art-recognized methods. Cancer stage refers to the extent or severity of the cancer, based on factors such as the location of the primary tumor, tumor size, number of tumors, and lymph node involvement (spread of cancer into lymph nodes). Alternatively, or in addition, severity is meant to describe the tumor grade by art-recognized methods (see, National Cancer Institute, www.cancer.gov). Tumor grade is a system used to classify cancer cells in terms of how abnormal they look under a microscope and how quickly the tumor is likely to grow and spread. Many factors are considered when determining tumor grade, including the structure and growth pattern of the cells. The specific factors used to determine tumor grade vary with each type of cancer. Severity also describes a histologic grade, also called differentiation, which refers to how much the tumor cells resemble normal cells of the same tissue type (see, National Cancer Institute, www.cancer.gov). Furthermore, severity describes a nuclear grade, which refers to the size and shape of the nucleus in tumor cells and the percentage of tumor cells that are dividing (see, National Cancer Institute, www.cancer.gov). 
     As used herein, the term “aggressive” indicates a cancer that can grow, form or spread quickly. Cancers termed aggressive may be susceptible to treatment, or they may resist treatment. An aggressive cancer can comprise any sort of cancer. Alternatively, or in addition, the term “aggressive” may describe a cancer that requires a more severe or intense than the usual form of treatment for that cancer. 
     As used herein, the term “refractory” describes a cancer that does not respond to an attempted form of treatment. Refractory cancers can also be termed resistant cancers. 
     In another aspect of the disclosure, severity describes the degree to which a tumor has secreted growth factors, degraded the extracellular matrix, become vascularized, lost adhesion to juxtaposed tissues, or metastasized. Moreover, severity describes the number of locations to which a primary tumor has metastasized. Finally, severity includes the difficulty of treating tumors of varying types and locations. For example, inoperable tumors, those cancers which have greater access to multiple body systems (hematological and immunological tumors), and those which are the most resistant to traditional treatments are considered most severe. In these situations, prolonging the life expectancy of the subject and/or reducing pain, decreasing the proportion of cancerous cells or restricting cells to one system, and improving cancer stage/tumor grade/histological grade/nuclear grade are considered alleviating a sign or symptom of the cancer. 
     As used herein the term “symptom” is defined as an indication of disease, illness, injury, or that something is not right in the body. Symptoms are felt or noticed by the individual experiencing the symptom, but may not easily be noticed by others. Others are defined as non-health-care professionals. 
     As used herein the term “sign” is also defined as an indication that something is not right in the body. But signs are defined as things that can be seen by a doctor, nurse, or other health care professional. 
     Cancer is a group of diseases that may cause almost any sign or symptom. The signs and symptoms will depend on where the cancer is, the size of the cancer, and how much it affects the nearby organs or structures. If a cancer spreads (metastasizes), then symptoms may appear in different parts of the body. 
     As a cancer grows, it begins to push on nearby organs, blood vessels, and nerves. This pressure creates some of the signs and symptoms of cancer. Cancers may form in places where it does not cause any symptoms until the cancer has grown quite large. 
     Cancer may also cause symptoms such as fever, fatigue, or weight loss. This may be because cancer cells use up much of the body&#39;s energy supply or release substances that change the body&#39;s metabolism. Or the cancer may cause the immune system to react in ways that produce these symptoms. While the signs and symptoms listed above are the more common ones seen with cancer, there are many others that are less common and are not listed here. However, all art-recognized signs and symptoms of cancer are contemplated and encompassed by the disclosure. 
     Treating cancer may result in a reduction in size of a tumor. A reduction in size of a tumor may also be referred to as “tumor regression”. Preferably, after treatment according to the methods of the disclosure, tumor size is reduced by 5% or greater relative to its size prior to treatment; more preferably, tumor size is reduced by 10% or greater; more preferably, reduced by 20% or greater; more preferably, reduced by 30% or greater; more preferably, reduced by 40% or greater; even more preferably, reduced by 50% or greater; and most preferably, reduced by greater than 75% or greater. Size of a tumor may be measured by any reproducible means of measurement. The size of a tumor may be measured as a diameter of the tumor. 
     Treating cancer may result in a reduction in tumor volume. Preferably, after treatment according to the methods of the disclosure, tumor volume is reduced by 5% or greater relative to its size prior to treatment; more preferably, tumor volume is reduced by 10% or greater; more preferably, reduced by 20% or greater; more preferably, reduced by 30% or greater; more preferably, reduced by 40% or greater; even more preferably, reduced by 50% or greater; and most preferably, reduced by greater than 75% or greater. Tumor volume may be measured by any reproducible means of measurement. 
     Treating cancer may result in a decrease in number of tumors. Preferably, after treatment, tumor number is reduced by 5% or greater relative to number prior to treatment; more preferably, tumor number is reduced by 10% or greater; more preferably, reduced by 20% or greater; more preferably, reduced by 30% or greater; more preferably, reduced by 40% or greater; even more preferably, reduced by 50% or greater; and most preferably, reduced by greater than 75%. Number of tumors may be measured by any reproducible means of measurement. The number of tumors may be measured by counting tumors visible to the naked eye or at a specified magnification. Preferably, the specified magnification is 2×, 3×, 4×, 5×, 10×, or 50×. 
     Treating cancer may result in a decrease in number of metastatic lesions in other tissues or organs distant from the primary tumor site. Preferably, after treatment according to the methods of the disclosure, the number of metastatic lesions is reduced by 5% or greater relative to number prior to treatment; more preferably, the number of metastatic lesions is reduced by 10% or greater; more preferably, reduced by 20% or greater; more preferably, reduced by 30% or greater; more preferably, reduced by 40% or greater; even more preferably, reduced by 50% or greater; and most preferably, reduced by greater than 75%. The number of metastatic lesions may be measured by any reproducible means of measurement. The number of metastatic lesions may be measured by counting metastatic lesions visible to the naked eye or at a specified magnification. Preferably, the specified magnification is 2×, 3×, 4×, 5×, 10×, or 50×. 
     Treating cancer can result in stabilization of disease where tumors neither progress nor regress. Preferably, stabilization will be maintained by more than 30 days; more preferably, by more than 60 days; more preferably, by more than 90 days; and most preferably, by more than 120 days. 
     Treating cancer can result in an increase in average survival time of a population of treated subjects in comparison to a population receiving carrier alone. Preferably, the average survival time is increased by more than 30 days; more preferably, by more than 60 days; more preferably, by more than 90 days; and most preferably, by more than 120 days. An increase in average survival time of a population may be measured by any reproducible means. An increase in average survival time of a population may be measured, for example, by calculating for a population the average length of survival following initiation of treatment with an active agent. An increase in average survival time of a population may also be measured, for example, by calculating for a population the average length of survival following completion of a first round of treatment with an active agent. 
     Treating cancer can result in an increase in average survival time of a population of treated subjects in comparison to a population of untreated subjects. Preferably, the average survival time is increased by more than 30 days; more preferably, by more than 60 days; more preferably, by more than 90 days; and most preferably, by more than 120 days. An increase in average survival time of a population may be measured by any reproducible means. An increase in average survival time of a population may be measured, for example, by calculating for a population the average length of survival following initiation of treatment with an active agent. An increase in average survival time of a population may also be measured, for example, by calculating for a population the average length of survival following completion of a first round of treatment with an active agent. 
     Treating cancer can result in increase in average survival time of a population of treated subjects in comparison to a population receiving monotherapy with a drug or standard of care that is not a nanoparticle composition of the present invention. Preferably, the average survival time is increased by more than 30 days; more preferably, by more than 60 days; more preferably, by more than 90 days; and most preferably, by more than 120 days. An increase in average survival time of a population may be measured by any reproducible means. An increase in average survival time of a population may be measured, for example, by calculating for a population the average length of survival following initiation of treatment with an active agent. An increase in average survival time of a population may also be measured, for example, by calculating for a population the average length of survival following completion of a first round of treatment with an active agent. 
     Treating cancer can result in a decrease in the mortality rate of a population of treated subjects in comparison to a population receiving carrier alone. Treating cancer can result in a decrease in the mortality rate of a population of treated subjects in comparison to an untreated population. Treating cancer can result in a decrease in the mortality rate of a population of treated subjects in comparison to a population receiving monotherapy with a drug that is not a pharmaceutical composition of the present invention. Preferably, the mortality rate is decreased by more than 2%; more preferably, by more than 5%; more preferably, by more than 10%; and most preferably, by more than 25%. A decrease in the mortality rate of a population of treated subjects may be measured by any reproducible means. A decrease in the mortality rate of a population may be measured, for example, by calculating for a population the average number of disease-related deaths per unit time following initiation of treatment with an active agent. A decrease in the mortality rate of a population may also be measured, for example, by calculating for a population the average number of disease-related deaths per unit time following completion of a first round of treatment with an active agent. 
     Treating cancer can result in a decrease in tumor growth rate. Preferably, after treatment, tumor growth rate is reduced by at least 5% relative to number prior to treatment; more preferably, tumor growth rate is reduced by at least 10%; more preferably, reduced by at least 20%; more preferably, reduced by at least 30%; more preferably, reduced by at least 40%; more preferably, reduced by at least 50%; even more preferably, reduced by at least 50%; and most preferably, reduced by at least 75%. Tumor growth rate may be measured by any reproducible means of measurement. Tumor growth rate can be measured according to a change in tumor diameter per unit time. 
     Treating cancer can result in a decrease in tumor regrowth. Preferably, after treatment, tumor regrowth is less than 5%; more preferably, tumor regrowth is less than 10%; more preferably, less than 20%; more preferably, less than 30%; more preferably, less than 40%; more preferably, less than 50%; even more preferably, less than 50%; and most preferably, less than 75%. Tumor regrowth may be measured by any reproducible means of measurement. Tumor regrowth is measured, for example, by measuring an increase in the diameter of a tumor after a prior tumor shrinkage that followed treatment. A decrease in tumor regrowth is indicated by failure of tumors to reoccur after treatment has stopped. 
     Treating cancer can result in a reduction in the rate of cellular proliferation. Preferably, after treatment, the rate of cellular proliferation is reduced by at least 5%; more preferably, by at least 10%; more preferably, by at least 20%; more preferably, by at least 30%; more preferably, by at least 40%; more preferably, by at least 50%; even more preferably, by at least 50%; and most preferably, by at least 75%. The rate of cellular proliferation may be measured by any reproducible means of measurement. The rate of cellular proliferation is measured, for example, by measuring the number of dividing cells in a tissue sample per unit time. 
     Treating cancer can result in a reduction in the proportion of proliferating cells. Preferably, after treatment, the proportion of proliferating cells is reduced by at least 5%; more preferably, by at least 10%; more preferably, by at least 20%; more preferably, by at least 30%; more preferably, by at least 40%; more preferably, by at least 50%; even more preferably, by at least 50%; and most preferably, by at least 75%. The proportion of proliferating cells may be measured by any reproducible means of measurement. Preferably, the proportion of proliferating cells is measured, for example, by quantifying the number of dividing cells relative to the number of nondividing cells in a tissue sample. The proportion of proliferating cells can be equivalent to the mitotic index. 
     Treating cancer can result in a decrease in size of an area or zone of cellular proliferation. Preferably, after treatment, size of an area or zone of cellular proliferation is reduced by at least 5% relative to its size prior to treatment; more preferably, reduced by at least 10%; more preferably, reduced by at least 20%; more preferably, reduced by at least 30%; more preferably, reduced by at least 40%; more preferably, reduced by at least 50%; even more preferably, reduced by at least 50%; and most preferably, reduced by at least 75%. Size of an area or zone of cellular proliferation may be measured by any reproducible means of measurement. The size of an area or zone of cellular proliferation may be measured as a diameter or width of an area or zone of cellular proliferation. 
     Treating cancer can result in a decrease in the number or proportion of cells having an abnormal appearance or morphology. Preferably, after treatment, the number of cells having an abnormal morphology is reduced by at least 5% relative to its size prior to treatment; more preferably, reduced by at least 10%; more preferably, reduced by at least 20%; more preferably, reduced by at least 30%; more preferably, reduced by at least 40%; more preferably, reduced by at least 50%; even more preferably, reduced by at least 50%; and most preferably, reduced by at least 75%. An abnormal cellular appearance or morphology may be measured by any reproducible means of measurement. An abnormal cellular morphology can be measured by microscopy, e.g., using an inverted tissue culture microscope. An abnormal cellular morphology can take the form of nuclear pleiomorphism. 
     Treating cancer can result in cell death, and preferably, cell death results in a decrease of at least 10% in number of cells in a population. More preferably, cell death means a decrease of at least 20%; more preferably, a decrease of at least 30%; more preferably, a decrease of at least 40%; more preferably, a decrease of at least 50%; most preferably, a decrease of at least 75%. Number of cells in a population may be measured by any reproducible means. A number of cells in a population can be measured by fluorescence activated cell sorting (FACS), immunofluorescence microscopy and light microscopy. Methods of measuring cell death are as shown in Li et al., Proc Natl Acad Sci USA. 100(5): 2674-8, 2003. In some aspects, cell death occurs by apoptosis. 
     Routes of Administration 
     Nanoparticles comprising dsRNAs or siRNAs targeting GPC2 can be administered to a subject by many of the well-known methods currently used for therapeutic treatment. For example, for treatment of cancers, a compositions comprising siRNAs targeting GPC2 may be injected directly into tumors, injected into the blood stream or body cavities or taken orally or applied through the skin with patches. The dose chosen should be sufficient to constitute effective treatment but not so high as to cause unacceptable side effects. The state of the disease condition (e.g., cancer, precancer, and the like) and the health of the patient should preferably be closely monitored during and for a reasonable period after treatment. 
     The compositions comprising nanoparticles comprising dsRNAs or siRNAs targeting GPC2 can be administered orally, nasally, transdermally, pulmonary, inhalationally, buccally, sublingually, intraperintoneally, subcutaneously, intramuscularly, intravenously, rectally, intrapleurally, intrathecally and parenterally. In some embodiments, the parenteral administration comprises intramuscular, intraperitoneal, subcutaneous or intravenous administration. One skilled in the art will recognize the advantages of certain routes of administration. 
     Compositions of the disclosure comprising nanoparticles may be administered parenterally. Systemic administration of compositions comprising nanoparticles of the disclosure can also be by intravenous, transmucosal, subcutaneous, intraperitoneal, intramuscular or transdermal means. For intravenous parenteral administration, compositions comprising nanoparticles may be administered by injection or by infusion. For transmucosal or transdermal administration, penetrants appropriate to the barrier to be permeated are used in the formulation. Such penetrants are generally known in the art, and include, for example, for transmucosal administration, detergents, bile salts, and fusidic acid derivatives. Transmucosal administration can be accomplished through the use of nasal sprays or suppositories. 
     Dosages 
     In therapeutic applications, the dosages of the pharmaceutical compositions used in accordance with the invention vary depending on the agent, the age, weight, and clinical condition of the recipient patient, and the experience and judgment of the clinician or practitioner administering the therapy, among other factors affecting the selected dosage. Generally, the dose should be sufficient to result in slowing, and preferably regressing, the growth of the tumors and also preferably causing complete regression of the cancer. Dosages may vary depending on the age and size of the subject and the type and severity of the cancer. 
     The term “therapeutically effective amount”, as used herein, refers to an amount of a pharmaceutical agent to treat, ameliorate, or prevent a cancer in a subject, or to exhibit a detectable therapeutic or inhibitory effect on said cancer in a subject. The effect can be detected by any assay method known in the art. The precise effective amount for a subject will depend upon the subject&#39;s body weight, size, and health; the nature and extent of the condition; and the therapeutic or combination of therapeutics selected for administration. Therapeutically effective amounts for a given situation can be determined by routine experimentation that is within the skill and judgment of the clinician. 
     For any dsRNA or siRNA, the therapeutically effective amount can be estimated initially either in cell culture assays, e.g., of neoplastic cells, or in animal models, usually rats, mice, rabbits, dogs, or pigs. The animal model may also be used to determine the appropriate concentration range and route of administration. In some embodiments, a standard xenograft or patient derived xenograft mouse model can be used to determine the effectiveness of GPC2 targeting dsRNAs or siRNAs on a cancer of the disclosure. Such information can then be used to determine useful doses and routes for administration in humans. Therapeutic/prophylactic efficacy and toxicity may be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., the maximum tolerated dose and no observable adverse effect dose. Pharmaceutical compositions that exhibit large therapeutic windows are preferred. The dosage may vary within this range depending upon the dosage form employed, sensitivity of the patient, and the route of administration. 
     Dosage and administration are adjusted to provide sufficient levels of the active agent(s) or to maintain the desired effect. Factors which may be taken into account include the severity of the disease state, general health of the subject, age, weight, and gender of the subject, diet, time and frequency of administration, drug combination(s), reaction sensitivities, and tolerance/response to therapy. Long-acting pharmaceutical compositions may be administered every 3 to 4 days, every week, or once every two weeks depending on half-life and clearance rate of the particular formulation. 
     The dosage of nanoparticles comprising dsRNAs or siRNAs required depends on the choice of the route of administration; the nature of the formulation; the nature of the patient&#39;s illness; the subject&#39;s size, weight, surface area, age, and sex; other drugs being administered; and the judgment of the attending physician. Wide variations in the needed dosage are to be expected in view of the differing efficiencies of various routes of administration. For example, oral administration would be expected to require higher dosages than administration by intravenous injection (e.g., 2-, 3-, 4-, 6-, 8-, 10-; 20-, 50-, 100-, 150-, or more fold). Variations in these dosage levels can be adjusted using standard empirical routines for optimization as is well understood in the art. Administrations can be single or multiple. Encapsulation of the inhibitor in a suitable delivery vehicle (e.g., capsules or implantable devices) may increase the efficiency of delivery, particularly for oral delivery. 
     A therapeutically effective dose of nanoparticles comprising GPC2 targeting dsRNAs or siRNAs described herein can optionally be combined with approved amounts of therapeutic agents, and described herein. For example, a therapeutically effective dose of the nanoparticles comprising dsRNAs or siRNAs described herein can be combined with a therapeutically effective amount of Cisplatin, Carboplatin, Cyclophosphamide, Doxorubicin, Topotecan or Etoposide. In some embodiments, a therapeutically effective dose of nanoparticles comprising GPC2 targeting dsRNAs or siRNAs described herein, and optionally, a therapeutically effective dose of an additional therapeutic agent, can be combined with a standard of care for a cancer. 
     Kits and Articles of Manufacture 
     The invention provides kits comprising any one or more of the compositions described herein, including but not limited to compositions comprising nanoparticles comprising siRNAs targeting GPC2, the nanoparticles optionally comprising one or more chemotherapeutic agents. The kits are for use in the treatment of cancer. 
     Nanoparticles comprising siRNAs targeting GPC2 can be lyophilized before being packaged in the kit, or can be provided in solution with a pharmaceutically acceptable carrier, diluent of excipient. 
     In some embodiments of the kits of the disclosure, the kit comprises a therapeutically effective amount of the composition comprising nanoparticles comprising siRNAs targeting GPC2, and instructions for use in the treatment of cancer. In some embodiments, the kit further comprises at least one additional cancer therapeutic agent, such as Cisplatin, Carboplatin, Cyclophosphamide, Doxorubicin, Topotecan or Etoposide. 
     In some embodiments, the nanoparticle comprises PLGA polymers and an HA targeting agent. 
     Articles of manufacture include, but are not limited to, instructions for use of the kit in treating cancers, for example astrocytoma, breast cancer, colorectal cancer, Ewing&#39;s sarcoma, gastric cancer, leiomyosarcoma, liver cancer, lung cancer, mesothelioma, ovarian cancer, pancreatic cancer, renal cancer, rhabdomyosarcoma or neuroblastoma. 
     In some embodiments, the kits further comprise instructions for administering the nanoparticles and pharmaceutical compositions comprising same of the disclosure. 
     All percentages and ratios used herein, unless otherwise indicated, are by weight. Other features and advantages of the present invention are apparent from the different examples. The provided examples illustrate different components and methodology useful in practicing the present invention. The examples do not limit the claimed invention. Based on the present disclosure the skilled artisan can identify and employ other components and methodology useful for practicing the present invention. 
     EXAMPLES 
     Example 1: Expression of Glypican-2 Across Multiple Cancer Cell Lines and Multiple Cancer Indications 
     GPC2 mRNA expression levels were determined across multiple cell lines and multiple cancer indications from the Cancer Genome Atlas database, a publicly available resource. Reads Per Kilobase of transcript per Million (RPKM) values were tabulated. Levels greater than 1 represent an increased level of GPC2 mRNA expression. As shown, a significant degree of GPC2 mRNA expression is present across all of the cell lines examined in this analysis. Levels of Glypican-2 are shown in Table 6: 
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 Glypican-2 expression in multiple cell 
               
               
                 lines and multiple cancer indications. 
               
            
           
           
               
               
               
            
               
                   
                   
                 Normalized GPC2 expression 
               
               
                 Indication 
                 Cell line 
                 (RPKM values) 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Astrocytoma 
                 U138MG 
                 4.36 
               
               
                   
                 LN18 
                 4.77 
               
               
                   
                 A172 
                 4.83 
               
               
                   
                 U118MG 
                 4.91 
               
               
                 Breast cancer 
                 BT549 
                 4.74 
               
               
                   
                 SKBR3 
                 4.78 
               
               
                   
                 MCF7 
                 5.06 
               
               
                 Colorectal cancer 
                 HCT116 
                 4.25 
               
               
                   
                 T84 
                 4.8 
               
               
                   
                 COLO205 
                 4.87 
               
               
                 Ewing&#39;s sarcoma 
                 TC-32 
                 5.26 
               
               
                   
                 TC71 
                 5.75 
               
               
                 Gastric Cancer 
                 AGS 
                 4.58 
               
               
                   
                 NCIN87 
                 4.59 
               
               
                   
                 KATOIII 
                 4.95 
               
               
                   
                 SNU16 
                 5.27 
               
               
                 Leiomyosarcoma 
                 SKUT1 
                 4.67 
               
               
                   
                 SKLMS1 
                 4.97 
               
               
                 Liver cancer 
                 HEPG2 
                 4.83 
               
               
                   
                 C3A 
                 5.01 
               
               
                   
                 HEP3B217 
                 5.08 
               
               
                   
                 JHH5 
                 5.11 
               
               
                 Lung cancer 
                 SW1271 
                 5.15 
               
               
                   
                 DMS114 
                 5.34 
               
               
                   
                 SHP77 
                 5.37 
               
               
                 Mesothelioma 
                 MSTO211H 
                 4.74 
               
               
                 Ovarian cancer 
                 COV362 
                 4.95 
               
               
                   
                 TOV112D 
                 5.06 
               
               
                   
                 SKOV3 
                 4.20 
               
               
                   
                 OV90 
                 5.16 
               
               
                 Pancreatic cancer 
                 HS766T 
                 4.24 
               
               
                   
                 BXPC3 
                 4.33 
               
               
                   
                 CAPAN1 
                 4.72 
               
               
                 Renal cancer 
                 A704 
                 4.35 
               
               
                   
                 786O 
                 4.36 
               
               
                   
                 CAKI1 
                 4.54 
               
               
                   
                 769P 
                 4.55 
               
               
                 Rhabdomyosarcoma 
                 RH18 
                 4.77 
               
               
                   
                 RH30 
                 5.16 
               
               
                   
                 RH41 
                 5.74 
               
               
                 Neuroblastoma 
                 MHHNB11 
                 7.64 
               
               
                   
                 KPNRTBM1 
                 7.77 
               
               
                   
                 SHSY5Y 
                 8.43 
               
               
                   
                 SKNAS 
                 5.01 
               
               
                   
                 CHP212 
                 5.04 
               
               
                   
                 IMR32 
                 6.53 
               
               
                   
               
            
           
         
       
     
     As can be seen in Table 6, GPC-2 is expressed in multiple cancer cell lines from astrocytoma, breast cancer, colorectal cancer, Ewing&#39;s sarcoma, gastric cancer, leiomyosarcoma, liver cancer, lung cancer, ovarian cancer, pancreatic cancer, renal cancer, rhadomyosarcoma and neuroblastoma cells, as well as a mesothelioma cell line. 
     GPC2 protein levels were assayed in neuroblastoma tumors, and levels of GPC2 protein were compared to normal tissues ( FIG. 1 ). GPC2 protein expression levels were determined across multiple tumor tissues and normal peripheral nerve tissues via immunohistochemistry using an antibody against GPC2. The degree of GPC2 staining was quantified using an automated image analyzer and plotted the percent GPC2 staining. Data show on average that significant expression of GPC2 can be detected in neuroblastoma tumors compared to normal tissues. 
     Example 2: GPC2 mRNA Knockdown Using siRNAs in TC-32 Ewing&#39;s Sarcoma Cells 
     Several siRNA sequences (n=15) were screened to determine their ability to knockdown (KD) GPC2 expression in multiple cancer cell lines. siRNA sequences were identified using an open source online tool available from either Sigma (sequences 1-11; see www.sigmaaldrich.com/life-science/custom-oligos/sima-oligos/sima-design-service.html or from Dharmacon (sequences 12-15; see dharmacon.horizondiscovery.com/custom-sima). The listed sequences span the full length of the mature GPC2 mRNA. Sense and anti-sense strands for representative siRNAs are shown in Table 7. 
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 GPC2 siRNAs. 
               
            
           
           
               
               
               
            
               
                 Name 
                 Sense 
                 Anti-sense 
               
               
                   
               
               
                 GPC2 
                 CUCCUGAUCCUGGCUGAUA[dT][dT] 
                 UAUCAGCCAGGAUCAGGAG[dT][dT] 
               
               
                 siRNA 1: 
                 (SEQ ID NO: 203) 
                 (SEQ ID NO: 204) 
               
               
                   
               
               
                 GPC2 
                 CUCAUCUACCGAUGGCUCU[dT][dT] 
                 AGAGCCAUCGGUAGAUGAG[dT][dT] 
               
               
                 siRNA 2: 
                 (SEQ ID NO: 205) 
                 (SEQ ID NO: 206) 
               
               
                   
               
               
                 GPC2 
                 CCUGCUUGGACCUCGAUAA[dT][dT] 
                 UUAUCGAGGUCCAAGCAGG[dT][dT] 
               
               
                 siRNA 3: 
                 (SEQ ID NO: 207) 
                 (SEQ ID NO: 208) 
               
               
                   
               
               
                 GPC2 
                 GUGGUUCGUGGCUGUCUCA[dT][dT] 
                 UGAGACAGCCACGAACCAC[dT][dT] 
               
               
                 siRNA 4: 
                 (SEQ ID NO: 209) 
                 (SEQ ID NO: 210) 
               
               
                   
               
               
                 GPC2 
                 CUCAGUAGCCCAGCACUCU[dT][dT] 
                 AGAGUGCUGGGCUACUGAG[dT][dT] 
               
               
                 siRNA 5: 
                 (SEQ ID NO: 211) 
                 (SEQ ID NO: 212) 
               
               
                   
               
               
                 GPC2 
                 CUGCUGUUCCAGUGAGACA[dT][dT] 
                 UGUCUCACUGGAACAGCAG[dT][dT] 
               
               
                 siRNA 6: 
                 (SEQ ID NO: 213) 
                 (SEQ ID NO: 214) 
               
               
                   
               
               
                 GPC2 
                 CUCCUUUCUGGUUCACACA[dT][dT] 
                 UGUGUGAACCAGAAAGGAG[dT][dT] 
               
               
                 siRNA 7: 
                 (SEQ ID NO: 215) 
                 (SEQ ID NO: 216) 
               
               
                   
               
               
                 GPC2 
                 GAGUGUGGUUUCCUUAGAA[dT][dT] 
                 UUCUAAGGAAACCACACUC[dT][dT] 
               
               
                 siRNA 8: 
                 (SEQ ID NO: 217) 
                 (SEQ ID NO: 218 
               
               
                   
               
               
                 GPC2 
                 GAGUACACCUGCUGUUCCA[dT][dT] 
                 UGGAACAGCAGGUGUACUC[dT][dT] 
               
               
                 siRNA 9: 
                 (SEQ ID NO: 219) 
                 (SEQ ID NO: 220) 
               
               
                   
               
               
                 GPC2 
                 GACACGACCUGGACGGGCA[dT][dT] 
                 UGCCCGUCCAGGUCGUGUC[dT][dT] 
               
               
                 siRNA 10: 
                 (SEQ ID NO: 221) 
                 (SEQ ID NO: 222) 
               
               
                   
               
               
                 GPC2 
                 CUGACUACCUGCUCUGCCU[dT][dT] 
                 AGGCAGAGCAGGUAGUCAG[dT][dT] 
               
               
                 siRNA 11: 
                 (SEQ ID NO: 223) 
                 (SEQ ID NO: 224) 
               
               
                   
               
               
                 GPC2 
                 GCGCUUAAGGUGCCGGUGU[dT][dT] 
                 ACACCGGCACCUUAAGCGC[dT][dT] 
               
               
                 siRNA 12: 
                 (SEQ ID NO: 225) 
                 (SEQ ID NO: 226) 
               
               
                   
               
               
                 GPC2 
                 CCUUUGAGCUGACGGCCGA[dT][dT] 
                 UCGGCCGUCAGCUCAAAGG[dT][dT] 
               
               
                 siRNA 13: 
                 (SEQ ID NO: 227) 
                 (SEQ ID NO: 228) 
               
               
                   
               
               
                 GPC2 
                 CCUGCUUCUGCUGCUGCCU[dT][dT] 
                 AGGCAGCAGCAGAAGCAGG[dT][dT] 
               
               
                 siRNA 14: 
                 (SEQ ID NO: 229) 
                 (SEQ ID NO: 230) 
               
               
                   
               
               
                 GPC2 
                 GAAGAAAUGUGGUCAGCGA[dT][dT] 
                 UCGCUGACCACAUUUCUUC[dT][dT] 
               
               
                 siRNA 15: 
                 (SEQ ID NO: 231) 
                 (SEQ ID NO: 232) 
               
               
                   
               
            
           
         
       
     
     Unless otherwise indicated, sequences in Table 7 refer to ribonucleic acids (RNAs). d[T] refers to deoxyribonucleic acids (DNA). 
     siRNAs 1-5 from Table 7 were diluted to 40 nM in OptiMEM media and mixed in a 1:3 ratio (weight by volume) with RNAiMAX. This was incubated for 15 minutes at room temperature and dispensed onto cells plated in a 6 well tissue culture plate. Total RNA samples were collected at either 72 hours post transfection to compare knockdown efficiency ( FIG. 2A ), or at 24, 48, 72 or 96 hours post transfection to determine the extent of GPC2 mRNA knockdown over time ( FIG. 2B ). Expression levels of mRNA of GPC2 were measured in these samples using primers specific for GPC2 obtained commercially from Thermofisher (Carlsbad, Calif.) and standard qPCR technique. Taken together these data indicate that the greatest degree of GPC2 knockdown was observed with sequences 3 and 5 and that knockdown lasts for at least 96 hours post transfection. 
     Example 3: GPC2 mRNA Knockdown Affects Cell Viability in Multiple Cancer Cell Lines 
     GPC2 mRNA knockdown and changes in cell viability were assessed in multiple cancer cell lines. Cells were transfected with either a scrambled control siRNA or with GPC2 siRNA sequence 3 or sequence 5 from Table 7 using the RNAiMAX Lipofectamine kit (Invitrogen, Carlsbad, Calif.) as previously described in Example 2, either in 96 well format (for viability assays) or 6 well format (for knockdown assessment). Following a 96 hour incubation period, cells were washed and the viability measurement was assessed using Cell Titer Glo 2.0. Total RNA was isolated from the 6 well plate samples to determine knockdown efficiency. 
     As shown in Table 8, although GPC2 knockdown was observed in each cell line using both sequences 3 and 5, the degree of GPC2 knockdown was cell line dependent. In most instances, knockdown of GPC2 expression resulted in a decrease in cell viability. 
     
       
         
           
               
             
               
                 TABLE 8 
               
             
            
               
                   
               
               
                 Effect of siRNA mediated GPC2 knockdown 
               
               
                 across multiple cancer cell lines 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 siRNA 
                 % GPC2 
                 % 
               
               
                 Cell Line 
                 Indication 
                 sequence 
                 knockdown 
                 Viability 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 MCF7 
                 Breast 
                 Sequence 3 
                 72 
                 79.67 
               
               
                   
                   
                 Sequence 5 
                 82 
                 67.11 
               
               
                 SKNAS 
                 Neuroblastoma 
                 Sequence 3 
                 25 
                 84.58 
               
               
                   
                   
                 Sequence 5 
                 44 
                 56.14 
               
               
                 CHP212 
                   
                 Sequence 3 
                 50 
                 70.18 
               
               
                   
                   
                 Sequence 5 
                 65 
                 64.46 
               
               
                 IMR32 
                   
                 Sequence 3 
                 36 
                 89.05 
               
               
                   
                   
                 Sequence 5 
                 25 
                 63.62 
               
               
                 RH30 
                 Rhabdomyosarcoma 
                 Sequence 3 
                 78 
                 79.02 
               
               
                   
                   
                 Sequence 5 
                 83 
                 46.03 
               
               
                 RH41 
                   
                 Sequence 3 
                 37 
                 131.49 
               
               
                   
                   
                 Sequence 5 
                 60 
                 31.32 
               
               
                 TC32 
                 Ewing&#39;s Sarcoma 
                 Sequence 3 
                 69 
                 78.24 
               
               
                   
                   
                 Sequence 5 
                 57 
                 77.18 
               
               
                 TC71 
                   
                 Sequence 3 
                 42 
                 102.39 
               
               
                   
                   
                 Sequence 5 
                 33 
                 100.92 
               
               
                 TOV112D 
                 Ovarian Carcinoma 
                 Sequence 3 
                 89 
                 152.77 
               
               
                   
                   
                 Sequence 5 
                 78 
                 81.15 
               
               
                 COV362 
                   
                 Sequence 3 
                 85 
                 102.76 
               
               
                   
                   
                 Sequence 5 
                 79 
                 94.27 
               
               
                 SNU16 
                 Gastric 
                 Sequence 3 
                 53 
                 92.74 
               
               
                   
                   
                 Sequence 5 
                 25 
                 89.01 
               
               
                 GIST-T1 
                 Gastrointestinal 
                 Sequence 3 
                 61 
                 70.87 
               
               
                   
                 Stromal 
                 Sequence 5 
                 76 
                 40.13 
               
               
                   
               
            
           
         
       
     
     Example 4: Comparison of the Activity of Multiple GPC2 siRNA Sequences in Neuroblastoma Cell Lines 
     GPC2 mRNA knockdown was assessed in multiple neuroblastoma cell lines. Cells were transfected with either a scrambled control siRNA, with GPC2 siRNA sequences 3 or 5 from Table 7, or with siRNA sequences generated by Dharmacon (sequences 12-15 from Table 7) using the RNAiMAX Lipofectamine kit (Invitrogen, Carlsbad, Calif.) as previously described. Following a 96 hour incubation period, total RNA samples were collected to compare knockdown efficiency and viability was measured in parallel plated cells. As shown, although GPC2 knockdown was observed in each cell line using most siRNA sequences ( FIG. 3A ), the degree of GPC2 knockdown was greater with sequences 3 and 5 and corresponding greater viability decrease was observed ( FIG. 3B ). 
     The extent of GPC2 mRNA reduction was assessed with additional GPC2 siRNA sequences in the CHP212 neuroblastoma cell line. Cells were transfected with either a scrambled control siRNA or with GPC2 siRNA sequences 3 or 5, or with siRNA sequences 6-11 (Sigma) using the RNAiMAX Lipofectamine kit (Invitrogen, Carlsbad, Calif.) as previously described. Following a 96 hour incubation period, total RNA samples were collected and viability was measured in parallel plated cells. As shown, although GPC2 knockdown was observed using most siRNA sequences ( FIG. 4A ), the degree of GPC2 knockdown was greater with sequences 5 and 7 and corresponding greater viability decrease was observed ( FIG. 4B ). 
     The extent of GPC2 mRNA reduction (knockdown) and corresponding protein level expression changes were assessed in three neuroblastoma cell lines following siRNA knockdown of GPC2. The CHP212 neuroblastoma cell line ( FIG. 5A  and  FIG. 5D ), the SH-SY5Y neuroblastoma cell line ( FIG. 5B  and  FIG. 5E ) and the CHLA90 neuroblastoma cell line ( FIG. 5C  and  FIG. 5F ) were transfected with GPC2 siRNA sequences 5 and 7 from Table 7 and a scrambled control siRNA using the RNAiMAX Lipofectamine kit (Invitrogen, Carlsbad, Calif.) as previously described. Following a 24, 48, or 72 hour incubation period, cells were washed and total RNA was isolated for measuring GPC2 mRNA expression. For protein analysis, cells were fixed, immunostained using an antibody against GPC2 protein, protein expression was measured via flow cytometry. As shown, GPC2 mRNA knockdown was observed beginning at the 24 hr time point and lasted for at least 72 hours. GPC2 protein expression started to decrease at the 48 hr time point. 
     Example 5: Knockdown of GPC2 mRNA Results in an Increased Sensitivity to Cisplatin 
     GPC2 mRNA was reduced using the indicated siRNAs and changes in cell viability were assessed in multiple cancer cell lines, in combination with Cisplatin treatment. Cells were transfected with either a scrambled control siRNA or with GPC2 siRNA sequences 3 or 5 from Table 7 using the RNAiMAX Lipofectamine kit (Invitrogen, Carlsbad, Calif.), as previously described, in either in 96 well (for viability assays) or 6 well format (for total RNA). Cisplatin was added at increasing concentrations (0 to 30 uM) to transfected cells at 24 hours post transfection. Following a 72 hour incubation period, cell viability was measured using Cell Titer Glo 2.0. Total RNA samples were also isolated to measure knockdown efficiency. As shown in Table 9 below, siRNA mediated knockdown of GPC2 was associated with an increase in the sensitivity to Cisplatin in several cell lines, most notably in neuroblastoma cells. 
     
       
         
           
               
             
               
                 TABLE 9 
               
             
            
               
                   
               
               
                 Effect of siRNA mediated GPC2 knockdown on sensitivity to Cisplatin in 
               
               
                 multiple cell lines 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                 % GPC2 
                   
                   
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                   
                 knockdown 
                 Cisplatin IC 50  (μM) 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Cell 
                   
                 siRNA 
                 siRNA 
                   
                 siRNA 
                 siRNA 
                   
               
               
                 Line 
                 Indication 
                 #3 1   
                 #5 2   
                 Ctl 3   
                 #3 1   
                 #5 2   
                 Data Summary 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 RH30 
                 Rhabdomyo-  
                 80 
                 86 
                 2.1 
                 2.1 
                 2.5 
                 KD 4  with sequence 3 or 5 
               
               
                   
                 sarcoma 
                   
                   
                   
                   
                   
                 does not increase 
               
               
                   
                   
                   
                   
                   
                   
                   
                 sensitivity to cisplatin 
               
               
                 RH41 
                   
                 55 
                 70 
                 3.9 
                 3.2 
                 1 
                 KD with sequence 5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                 cisplatin 
               
               
                 SNU16 
                 Gastric 
                 50 
                 52 
                 16 
                 16 
                 16 
                 KD with sequence 3 or 5 
               
               
                   
                 carcinoma 
                   
                   
                   
                   
                   
                 does not increase 
               
               
                   
                   
                   
                   
                   
                   
                   
                 sensitivity to cisplatin 
               
               
                 GIST- 
                 Gastrointestinal 
                 55 
                 75 
                 9 
                 13 
                 1  
                 KD with sequence 5 
               
               
                 T1 
                 Stromal 
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                 cisplatin 
               
               
                 TOV112D 
                 Ovarian 
                 90 
                 86 
                 4 
                 5 
                 7 
                 KD with sequence 3 and 5 
               
               
                   
                 cancer 
                   
                   
                   
                   
                   
                 does not increase 
               
               
                   
                   
                   
                   
                   
                   
                   
                 sensitivity to cisplatin 
               
               
                 COV362 
                   
                 85 
                 89 
                 6.1 
                 6.4 
                 18 
                 KD with sequence 3 or 5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 does not increase 
               
               
                   
                   
                   
                   
                   
                   
                   
                 sensitivity to cisplatin 
               
               
                 TC32 
                 Ewing&#39;s 
                 70 
                 75 
                 1.2 
                 2.3 
                 1.2 
                 KD with sequence 3 or 5 
               
               
                   
                 sarcoma 
                   
                   
                   
                   
                   
                 does not increase 
               
               
                   
                   
                   
                   
                   
                   
                   
                 sensitivity to cisplatin 
               
               
                 TC71 
                   
                 55 
                 60 
                 1.4 
                 1.3 
                 1.4 
                 KD with sequence 3 or 5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 does not increase 
               
               
                   
                   
                   
                   
                   
                   
                   
                 sensitivity to cisplatin 
               
               
                 CHP212 
                 Neuroblastoma 
                 60 
                 70 
                 14.0 
                 7.4 
                 6.0 
                 KD with sequence 3 or 5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                 cisplatin 
               
               
                 SKNAS 
                   
                 40 
                 70 
                 60 
                 20 
                 9 
                 KD with sequence 3 or 5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                 cisplatin 
               
               
                 SH- 
                   
                 55 
                 75 
                 15.4 
                 17.6 
                 9.3 
                 KD with sequence 5 
               
               
                 SY5Y 
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                 cisplatin 
               
               
                 KELLY 
                   
                 65 
                 75 
                 19.4 
                 21.7 
                 2.5 
                 KD with sequence 5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                 cisplatin 
               
               
                 SK-N- 
                   
                 55 
                 68 
                 9 
                 8 
                 3 
                 KD with sequence 5 
               
               
                 BE2 
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                 cisplatin 
               
               
                 CHLA- 
                   
                 50 
                 55 
                 23 
                 15 
                 15 
                 KD with sequence 3 or 5 
               
               
                 90  
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                 cisplatin 
               
               
                 CHL A- 
                   
                 25 
                 35 
                 24 
                 11 
                 6 
                 KD with sequence 3 or 5 
               
               
                 136 
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                 cisplatin 
               
               
                 CHLA- 
                   
                 5 
                 8 
                 18 
                 16 
                 17 
                 KD with sequence 3 or 5 
               
               
                 172 
                   
                   
                   
                   
                   
                   
                 does not increase 
               
               
                   
                   
                   
                   
                   
                   
                   
                 sensitivity to cisplatin 
               
               
                   
               
               
                   1 siRNA sequence #3 from Table 7 
               
               
                   2 siRNA sequence #5 from Table 7 
               
               
                   3 scrambled control siRNA 
               
               
                   4 KD; knockdown 
               
            
           
         
       
     
     Example 6: Knockdown of GPC2 mRNA Results in an Increased Sensitivity to Carboplatin 
     GPC2 mRNA expression was reduced using the indicated siRNAs and changes in cell viability were assessed in multiple neuroblastoma cell lines. Cells were transfected with either a control siRNA or with GPC2 siRNA sequences 3, 5 or 7 from Table 7 using the RNAiMAX Lipofectamine kit (Invitrogen, Carlsbad, Calif.) as previously described in 96 wells for viability assays. Carboplatin was added at increasing concentrations (0 to 150 uM) to transfected cells at 24 hours post transfection. Following a 72 hour incubation period, viability measurements were made using Cell Titer Glo 2.0. Representative data for GPC2 knockdown with individual siRNAs generated from a separate experiment are shown in Table 10. As shown in Table 10 below, knockdown of GPC2 was associated with an increase in the sensitivity to carboplatin in several cell lines. 
     
       
         
           
               
             
               
                 TABLE 10 
               
             
            
               
                   
               
               
                 Effect of siRNA mediated GPC2 knockdown on sensitivity to Carboplatin in 
               
               
                 multiple cell lines 
               
            
           
           
               
               
               
               
               
               
            
               
                 Cell 
                 Ctl 1   
                 siRNA #3 2   
                 siRNA #5 3   
                 siRNA #7 4   
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 Line 
                 IC 50   5   
                 % KD 6   
                 IC 50   5   
                 % KD 6   
                 IC 50   5   
                 % KD 6   
                 IC 50   5   
                 Data Summary 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 CHP212 
                 23.19 
                 60 
                 19.89 
                 70 
                 10.41 
                 70 
                 8.14 
                 KD 7  with sequence 3, 5 or 7 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 carboplatin 
               
               
                 SKNAS 
                 220 
                 40 
                 40 
                 70 
                 15.3 
                 64 
                 Not 
                 KD with sequence 3 or 5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 tested 
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 carboplatin 
               
               
                 SH- 
                 1.89 
                 55 
                 2.3 
                 75 
                 1.55 
                 70 
                 0.47 
                 KD with sequence 5 or 7 
               
               
                 SY5Y 
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 carboplatin 
               
               
                 KELLY 
                 13 
                 65 
                 12 
                 75 
                 9 
                 73 
                 Not 
                 KD with sequence 5 increases 
               
               
                   
                   
                   
                   
                   
                   
                   
                 tested 
                 sensitivity to carboplatin 
               
               
                 SK-N- 
                 30.99 
                 55 
                 27.9 
                 68 
                 11 
                 69 
                 2.5 
                 KD with sequence 3, 5 or 7 
               
               
                 BE2 
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 carboplatin 
               
               
                 CHLA- 
                 150 
                 50 
                 100 
                 55 
                 100 
                 65 
                 15 
                 KD with sequence 3, 5 or 7 
               
               
                 90 
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 carboplatin 
               
               
                 CHLA- 
                 31 
                 25 
                 47 
                 35 
                 36 
                 30 
                 Not 
                 KD with sequence 3 or 5, does 
               
               
                 136 
                   
                   
                   
                   
                   
                   
                 tested 
                 not increase sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 carboplatin 
               
               
                 CHLA- 
                 110 
                 5 
                 100 
                 8 
                 100 
                 20 
                 Not 
                 KD with sequence 3 or 5 
               
               
                 172 
                   
                   
                   
                   
                   
                   
                 tested 
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 carboplatin 
               
               
                   
               
               
                   1 Ctl; scrambled control siRNA 
               
               
                   2 siRNA #3; siRNA with sequence 3 from Table 7 
               
               
                   3 siRNA #5; siRNA with sequence 5 from Table 7 
               
               
                   4 siRNA #7; siRNA with sequence 7 from Table 7 
               
               
                   5 IC 50 ; carboplatin IC 50  in cells transfected with the control siRNA or GPC2 siRNAs, as indicated, in μM 
               
               
                   6 % KD; percent GPC2 mRNA reduction (knockdown) observed with the indicated siRNA, compared to scrambled siRNA control 
               
               
                   7 KD; knockdown 
               
            
           
         
       
     
     Example 7: Knockdown of GPC2 mRNA Results in an Increased Sensitivity to Cyclophosphamide 
     GPC2 mRNA expression was reduced with the indicated siRNAs and changes in cell viability were assessed in multiple neuroblastoma cell lines. Cells were transfected with either a control siRNA or with GPC2 siRNA sequences 3, 5 or 7 from Table 7 using the RNAiMAX Lipofectamine kit (Invitrogen, Carlsbad, Calif.) as previously described in 96 wells for viability assays. Cyclophosphamide was added at increasing concentrations (0-20 uM) to transfected cells at 24 hr post transfection. Following a 72 hour incubation period, viability measurements were made using Cell Titer Glo 2.0. Representative data for GPC2 knockdown with individual siRNAs generated from a separate experiment are shown in Table 11. As shown in Table 11 below, knockdown of GPC2 mRNA was associated with an increase in the sensitivity to Cyclophosphamide in several cell lines. 
     
       
         
           
               
             
               
                 TABLE 11 
               
             
            
               
                   
               
               
                 Effect of siRNA mediated GPC2 knockdown on sensitivity to 
               
               
                 Cyclophosphamide in multiple cell lines 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Ctl 1   
                 siRNA #3 2   
                 siRNA #5 3   
                 siRNA #7 4   
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 Cell 
                 IC 50   
                 % 
                 IC 50   
                 % 
                 IC 50   
                 % 
                 IC 50   
                   
               
               
                 Line 
                 (μM) 5   
                 KD 6   
                 (μM) 5   
                 KD 6   
                 (μM) 5   
                 KD 6   
                 (μM) 5   
                 Data Summary 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 CHP212 
                 1.36 
                 60 
                 0.87 
                 70 
                 0.45 
                 70 
                 1.2 
                 KD 7  with sequence 3, 5 or 7 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 cyclophosphamide 
               
               
                 SKNAS 
                 12 
                 40 
                 1.37 
                 70 
                 0.48 
                 64 
                 Not 
                 KD with sequence 3 or 5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 tested 
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 cyclophosphamide 
               
               
                 SH- 
                 2 
                 55 
                 1.5 
                 75 
                 0.3 
                 70 
                 0.94 
                 KD with sequence 3, 5 or 7 
               
               
                 SY5Y 
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 cyclophosphamide 
               
               
                 KELLY 
                 10 
                 65 
                 8 
                 75 
                 1 
                 73 
                 Not 
                 KD with sequence 3 or 5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 tested 
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 cyclophosphamide 
               
               
                 SK-N- 
                 4.17 
                 55 
                 2.41 
                 68 
                 1.8 
                 69 
                 0.41 
                 KD with sequence 3, 5 or 7 
               
               
                 BE2 
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 cyclophosphamide 
               
               
                 CHLA- 
                 30 
                 50 
                 30 
                 55 
                 20 
                 65 
                 10 
                 KD with sequence 5 or 7 
               
               
                 90 
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 cyclophosphamide 
               
               
                 CHLA- 
                 6 
                 25 
                 11 
                 35 
                 5 
                 30 
                 Not 
                 KD sequence 3 or 5 does 
               
               
                 136 
                   
                   
                   
                   
                   
                   
                 tested 
                 not increase sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 cyclophosphamide 
               
               
                 CHLA- 
                 15 
                 5 
                 10 
                 8 
                 10 
                 20 
                 Not 
                 KD with sequence 3 or 5 
               
               
                 172 
                   
                   
                   
                   
                   
                   
                 tested 
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 cyclophosphamide 
               
               
                   
               
               
                   1 Ctl; scrambled control siRNA 
               
               
                   2 siRNA #3; siRNA with sequence 3 from Table 7 
               
               
                   3 siRNA #5; siRNA with sequence 5 from Table 7 
               
               
                   4 siRNA #7; siRNA with sequence 7 from Table 7 
               
               
                   5 IC 50  (μM); Cyclophosphamide IC 50  in microMolar concentration (μM), in cells transfected with the control siRNA or GPC2 siRNAs, as indicated 
               
               
                   6 % KD; percent GPC2 mRNA reduction (knockdown) observed with the indicated siRNA 
               
               
                   7 KD; knockdown 
               
            
           
         
       
     
     Example 8: Knockdown of GPC2 mRNA Results in an Increased Sensitivity to Doxorubicin 
     GPC2 mRNA expression was reduced and changes in cell viability were assessed in multiple neuroblastoma cell lines. Cells were transfected with either a control siRNA or with GPC-2 siRNA sequences 3, 5 or 7 from Table 7 using the RNAiMAX Lipofectamine kit (Invitrogen, Carlsbad, Calif.) as previously described in 96 wells for viability assays. Doxorubicin was added at increasing concentrations (0-5 uM) to transfected cells at 24 hours post transfection. Following a 72 hour incubation period, viability measurements were made using Cell Titer Glo. Representative data for GPC2 knockdown with individual siRNAs generated from a separate experiment are shown in Table 12. As shown in Table 12 below, knockdown of GPC2 was associated with an increase in the sensitivity to Doxorubicin in several cell lines. 
     
       
         
           
               
             
               
                 TABLE 12 
               
             
            
               
                   
               
               
                 Effect of siRNA mediated GPC2 knockdown on sensitivity to 
               
               
                 Cyclophosphamide in multiple cell lines 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Ctl 1   
                 siRNA #3 2   
                 siRNA #5 3   
                 siRNA #7 4   
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 Cell 
                 IC 50   
                 % 
                 IC 50   
                 % 
                 IC 50   
                 % 
                 IC 50   
                   
               
               
                 Line 
                 (μM) 5   
                 KD 6   
                 (μM) 5   
                 KD 6   
                 (μM) 5   
                 KD 6   
                 (μM) 5   
                 Data Summary 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 CHP212 
                 0.03 
                 60 
                 0.03 
                 70 
                 0.02 
                 70 
                 0.02 
                 KD7 with sequence 3, 5 or 7 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 does not increase sensitivity 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 to doxorubicin 
               
               
                 SKNAS 
                 0.14 
                 40 
                 0.04 
                 70 
                 0.02 
                 64 
                 Not 
                 KD with sequence 3 or 5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 tested 
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 doxorubicin 
               
               
                 SH- 
                 0.06 
                 55 
                 0.08 
                 75 
                 0.05 
                 70 
                 0.03 
                 KD with sequence 7 increases 
               
               
                 SY5Y 
                   
                   
                   
                   
                   
                   
                   
                 sensitivity to doxorubicin 
               
               
                 KELLY 
                 0.07 
                 65 
                 0.07 
                 75 
                 0.06 
                 73 
                 Not 
                 KD with sequence 3 or 5 does 
               
               
                   
                   
                   
                   
                   
                   
                   
                 tested 
                 not increase sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 doxorubicin 
               
               
                 SK-N- 
                 1 
                 55 
                 1 
                 68 
                 0.02 
                 69 
                 0.2 
                 KD with sequence 5 or 7 
               
               
                 BE2 
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 doxorubicin 
               
               
                 CHLA- 
                 0.36 
                 50 
                 0.35 
                 55 
                 0.25 
                 65 
                 0.13 
                 KD with sequence 5 or 7 
               
               
                 90 
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 doxorubicin 
               
               
                 CHLA- 
                 0.14 
                 25 
                 0.17 
                 35 
                 0.08 
                 30 
                 Not 
                 KD with sequence 5 increases 
               
               
                 136 
                   
                   
                   
                   
                   
                   
                 tested 
                 sensitivity to doxorubicin 
               
               
                 CHLA- 
                 2 
                 5 
                 2 
                 8 
                 0.9 
                 20 
                 Not 
                 KD with sequence 5 increases 
               
               
                 172 
                   
                   
                   
                   
                   
                   
                 tested 
                 sensitivity to doxorubicin 
               
               
                   
               
               
                   1 Ctl; scrambled control siRNA 
               
               
                   2 siRNA #3; siRNA with sequence 3 from Table 7 
               
               
                   3 siRNA #5; siRNA with sequence 5 from Table 7 
               
               
                   4 siRNA #7; siRNA with sequence 7 from Table 7 
               
               
                   5 IC 50  (μM); Doxorubicin IC 50  in microMolar concentration (μM), in cells transfected with the control siRNA or GPC2 siRNAs, as indicated 
               
               
                   6 % KD; percent GPC2 mRNA reduction (knockdown) observed with the indicated siRNA 
               
               
                   7 KD; knockdown 
               
            
           
         
       
     
     Example 9: Knockdown of GPC2 mRNA Results in an Increased Sensitivity to Etoposide 
     GPC2 mRNA expression was reduced and changes in cell viability were assessed in multiple neuroblastoma cell lines. Cells were transfected with either a control siRNA or with GPC2 siRNA sequences 3, 5 or 7 from Table 7 using the RNAiMAX Lipofectamine kit (Invitrogen, Carlsbad, Calif.) as previously described in 96 wells for viability assays. Etoposide was added at increasing concentrations (0-15 uM) to transfected cells at 24 hours post transfection. Following a 72 hour incubation period, viability measurement were made using Cell Titer Glo 2.0. Representative data for GPC2 knockdown with individual siRNAs generated from a separate experiment are shown in Table 13. As shown in Table 13, knockdown of GPC2 was associated with an increase in the sensitivity to Etoposide in several cell lines. 
     
       
         
           
               
             
               
                 TABLE 13 
               
             
            
               
                   
               
               
                 Effect of siRNA mediated GPC2 knockdown on sensitivity to Etoposide in 
               
               
                 multiple cell lines 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Ctl 1   
                 siRNA #3 2   
                 siRNA #5 3   
                 siRNA #7 4   
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 Cell 
                 IC 50   
                 % 
                 IC 50   
                 % 
                 IC 50   
                 % 
                 IC 50   
                   
               
               
                 Line 
                 (μM) 5   
                 KD 6   
                 (μM) 5   
                 KD 6   
                 (μM) 5   
                 KD 6   
                 (μM) 5   
                 Data Summary 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 CHP212 
                 0.03 
                 60 
                 0.03 
                 70 
                 0.02 
                 70 
                 0.02 
                 Knockdown with sequence 5 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to etoposide 
               
               
                 SKNAS 
                 0.14 
                 40 
                 0.04 
                 70 
                 0.02 
                 64 
                 Not 
                 Knockdown with sequence 3 or 5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 tested 
                 increases sensitivity to etoposide 
               
               
                 SH- 
                 0.06 
                 55 
                 0.08 
                 75 
                 0.05 
                 70 
                 0.03 
                 Knockdown with sequence 3, 5 or 
               
               
                 SY5Y 
                   
                   
                   
                   
                   
                   
                   
                 7 increases sensitivity to etoposide 
               
               
                 KELLY 
                 0.07 
                 65 
                 0.07 
                 75 
                 0.06 
                 73 
                 Not 
                 Knockdown with sequence 3 or 5 
               
               
                   
                   
                   
                   
                   
                   
                   
                 tested 
                 increases sensitivity to etoposide 
               
               
                 SK-N- 
                 1 
                 55 
                 1 
                 68 
                 0.02 
                 69 
                 0.2 
                 Knockdown with sequence 3, 5 or 
               
               
                 BE2 
                   
                   
                   
                   
                   
                   
                   
                 7 increases sensitivity to etoposide 
               
               
                 CHLA- 
                 0.36 
                 50 
                 0.35 
                 55 
                 0.25 
                 65 
                 0.13 
                 Knockdown with sequence 5 or 7 
               
               
                 90 
                   
                   
                   
                   
                   
                   
                   
                 increases sensitivity to etoposide 
               
               
                 CHLA- 
                 0.14 
                 25 
                 0.17 
                 35 
                 0.08 
                 30 
                 Not 
                 Knockdown with sequence 3 
               
               
                 136 
                   
                   
                   
                   
                   
                   
                 tested 
                 increases sensitivity to etoposide 
               
               
                 CHLA- 
                 2 
                 5 
                 2 
                 8 
                 0.9 
                 20 
                 Not 
                 Knockdown with sequence 3 or 5 
               
               
                 172 
                   
                   
                   
                   
                   
                   
                 tested  
                 increases sensitivity to etoposide 
               
               
                   
               
               
                   1 Ctl; scrambled control siRNA 
               
               
                   2 siRNA #3; siRNA with sequence 3 from Table 7 
               
               
                   3 siRNA #5; siRNA with sequence 5 from Table 7 
               
               
                   4 siRNA #7; siRNA with sequence 7 from Table 7 
               
               
                   5 IC 50  (μM); Etoposide IC 50  in microMolar concentration (μM), in cells transfected with the control siRNA or GPC2 siRNAs, as indicated 
               
               
                   6 % KD; percent GPC2 mRNA reduction (knockdown) observed with the indicated siRNA 
               
            
           
         
       
     
     Example 10: Knockdown of GPC2 mRNA Results in an Increased Sensitivity to Topotecan 
     GPC2 mRNA expression was reduced and changes in cell viability were assessed in multiple neuroblastoma cell lines. Cells were transfected with either a control siRNA or with GPC2 siRNA sequences 5 or 7 from Table 7 using the RNAiMAX Lipofectamine kit (Invitrogen, Carlsbad, Calif.) as previously described in 96 wells for viability assays. Topotecan was added at increasing concentrations (0-5 uM) to transfected cells at 24 hours post transfection. Following a 72 hour incubation period, viability measurements were made using Cell Titer Glo 2.0. Representative data for GPC2 knockdown with individual siRNAs generated from a separate experiment are shown in Table 14. As shown in Table 14, knockdown of GPC2 was associated with an increase in the sensitivity to Topotecan in several cell lines. 
     
       
         
           
               
             
               
                 TABLE 14 
               
             
            
               
                   
               
               
                 Effect of siRNA mediated GPC2 knockdown on sensitivity to Topotecan in 
               
               
                 multiple cell lines 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 Control 
                   
                   
                   
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 siRNA 
                 siRNA #5 1   
                 siRNA #7 2   
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Cell 
                 IC 50   
                 % 
                 IC 50   
                 % 
                 IC 50   
                   
               
               
                 Line 
                 (μM) 3   
                 KD 4   
                 (μM) 3   
                 KD 4   
                 (μM) 3   
                 Data Summary 
               
               
                   
               
               
                 CHP212 
                 0.02 
                 70 
                 0.01 
                 70 
                 0.01 
                 Knockdown with sequence 5 or 7 does 
               
               
                   
                   
                   
                   
                   
                   
                 not increase sensitivity to topotecan 
               
               
                 SKNAS 
                 1.42 
                 70 
                 0.02 
                 64 
                 0.02 
                 Knockdown with sequence 5 or 7 
               
               
                   
                   
                   
                   
                   
                   
                 increases sensitivity to topotecan 
               
               
                 SH- 
                 0.05 
                 75 
                 0.04 
                 70 
                 0.04 
                 Knockdown with sequence 5 or 7 does 
               
               
                 SY5Y 
                   
                   
                   
                   
                   
                 not increase sensitivity to topotecan 
               
               
                 KELLY 
                 0.03 
                 75 
                 0.06 
                 73 
                 0.02 
                 Knockdown with sequence 5 or 7 does 
               
               
                   
                   
                   
                   
                   
                   
                 not increase sensitivity to topotecan 
               
               
                 SK-N- 
                 0.02 
                 68 
                 0.01 
                 69 
                 0.01 
                 Knockdown with sequence 5 or 7 does 
               
               
                 BE2 
                   
                   
                   
                   
                   
                 not increase sensitivity to topotecan 
               
               
                 CHLA- 
                 0.03 
                 55 
                 0.11 
                 65 
                 0.14 
                 Knockdown with sequence 5 or 7 does 
               
               
                 90 
                   
                   
                   
                   
                   
                 not increase sensitivity to topotecan 
               
               
                   
               
               
                   1 siRNA #5; siRNA with sequence 5 from Table 7 
               
               
                   2 siRNA #7; siRNA with sequence 7 from Table 7 
               
               
                   3 IC 50  (μM); Etoposide IC 50  in microMolar concentration (μM), in cells transfected with the control siRNA or GPC2 siRNAs, as indicated 
               
               
                   4 % KD; percent GPC2 mRNA reduction (knockdown) observed with the indicated siRNA 
               
            
           
         
       
     
     Example 11: Knockdown of GPC2 mRNA Affects Tumor Spheroid Formation 
     The effect of GPC2 knockdown on tumor spheroid formation was assessed. CHP212, SKNAS, SKNBE2 or CHLA90 neuroblastoma cells were transfected with either a scrambled control siRNA or with a GPC2 siRNA of sequence 5 from Table 7 using the RNAiMAX Lipofectamine kit (Invitrogen, Carlsbad, Calif.), as previously described. Following transfection, cells were plated in a low attachment 96 well plate for spheroid formation while under siRNA treatment. At 96 hours following transfection, spheroid images were taken using the Evos FL microscope ((Life Technologies, Carlsbad, Calif.) at 100× magnification. As shown in  FIG. 6 , cells that exhibited the highest degree of GPC2 mRNA knockdown showed the greatest inhibition in their ability to form spheroids. 
     The effect of siRNA mediated GPC2 mRNA knockdown was also assessed on established spheroid cultures. Spheroids were established by seeding cells in low attachment plates and culturing for 96 hours. Spheroids were transfected with either a scrambled control siRNA or with GPC2 siRNA of sequence 5 or 7 from Table 7, using the RNAiMAX Lipofectamine kit (Invitrogen, Carlsbad, Calif.) as previously described. At the 96 hour time point following transfection, the degree of GPC2 mRNA knockdown ( FIG. 7A ) as well as spheroid viability ( FIG. 7B ) was measured. As shown in  FIGS. 7A and 7B , where GPC2 knockdown was observed, a decrease in spheroid viability was also seen. 
     Testing the effect of GPC2 mRNA knockdown on spheroids showed similar cytotoxicity to that seen in two dimensional cultures. GPC2 knockdown not only inhibited the formation of tumor spheroids, it also decreased cell viability after spheroids had already formed. This suggests that targeting this pathway may affect both established primary tumors as well as formation of new metastatic lesions.