Patent Publication Number: US-5523378-A

Title: Process for preparing vinylphenol polymers &amp; copolymers

Description:
RELATED APPLICATIONS 
     This application is a continuation-in-part of commonly owned patent application Ser. No. 08/406,351 filed Mar. 17, 1995 now U.S. Pat. No. 5,453,481. 
    
    
     BACKGROUND OF THE INVENTION 
     1. Field of the Invention 
     The present invention relates to a process for the production of poly(4-hydroxystyrene) (PHS) directly from 4-hydroxyphenylmethylcarbinol (HPMC) which in turn is prepared from 4-hydroxyacetophenone (4-HAP). 
     2. Description of the Prior Art 
     It is known in the art to produce 4-hydroxystyrene (HSM) and derivatives thereof such as poly(4-hydroxystyrene) (PHS), which have applications in the production of adhesives, coating compositions, photoresists, and the like. In the PHS area, there is a need to produce such material in the least amount of process steps in order to provide efficiency. The prior art has utilized a five-step process in order to produce PHS. We have now found that PHS can be produced in three steps or less. 
     In the past, one of the ways of preparing poly(4-hydroxystyrene) (PHS) was the use of 4-hydroxystyrene (HSM) as the starting material; note European Patent Application No. 0-108-624. 4-Hydroxystyrene (HSM) is a well-known compound in the art. 
     Although there are several known ways to prepare 4-hydroxystyrene, these known methods are not commercially feasible in the further utilization of the 4-hydroxystyrene. The 4-hydroxystyrene itself is difficult to isolate, since it (1) readily decomposes, and (2) is toxic via skin absorption, and, as a result, those skilled in the art have made numerous attempts at finding a method of synthesizing PHS in a manner which avoids using the 4-hydroxystyrene as the starting material. 
     The following prior art references are disclosed in accordance with the terms of 37 CFR 1.56, 1.97, and 1.93. 
     U.S. Pat. No. 5,087,772 (issued Feb. 11, 1992) discloses the preparation of HSM by reacting 4-acetoxystyrene (ASM) with a suitable alcohol in the presence of a catalytic amount of a suitable base. 
     European Patent Application No. 0-128-984 (publication no.), filed Aug. 30, 1983, discloses a process for the production of para-vinyl phenol (HSM) by dehydrogenation of para-ethyl phenol. 
     European Patent Application No. 0-108-624 (publication no.), filed Nov. 4, 1983, discloses a process for the production of p-vinyl phenol polymer (polyhydroxystyrene polymer--PHS) by polymerizing p-vinyl phenol (HSM) in the presence of water and iron. 
     U.S. Pat. No. 4,032,513 (issued Jun. 28, 1977) discloses a process of producing PHS by cationically polymerizing HSM in the presence of a nitrile, such as CH 3  CN, using a cationic polymerization initiator in a homogeneous reaction system. 
     U.S. Pat. No. 5,041,614 discloses a method for the preparation of 4-acetoxystyrene (ASM) from 4-acetoxyphenylmethylcarbinol. (Note Formula I for the structural formula for ASM). 
     U.S. Pat. No. 5,084,533 discloses a process for the neat hydrogenation of 4-acetoxyacetophenone in the production of 4-acetoxystyrene (ASM). 
     U.S. Pat. No. 5,151,546 discloses a process for preparing 4-acetoxystyrene (ASM) by heating 4-acetoxyphenylmethylcarbinol with an acid catalyst. 
     U.S. Pat. No. 5,245,074 discloses a process for preparing 4-acetoxystyrene (ASM) through the 4-acetoxyacetophenone/4-acetoxyphenylmethylcarbinol route. 
     U.S. Pat. No. 5,247,124 discloses a process for preparing substituted styrenes such as ASM by reacting a bisarylalkyl ether in the presence of an acid catalyst. 
     J. Org. Chem., (1954), 19, 1205, discloses the use of copper chromite catalysts in the hydrogenation of ketones. 
     Other prior art references which relate to the present invention include U.S. Pat. No. 2,276,138; U.S. Pat. No. 3,547,858; U.S. Pat. No. 4,544,704; U.S. Pat. No. 4,678,843; U.S. Pat. No. 4,689,371; U.S. Pat. No. 4,822,862; U.S. Pat. No. 4,857,601; U.S. Pat. No. 4,868,256; U.S. Pat. No. 4,877,843; U.S. Pat. No. 4,898,916; U.S. Pat. No. 4,912,173; U.S. Pat. No. 4,962,147; U.S. Pat. No. 4,965,400; U.S. Pat. No. 4,880,487; U.S. Pat. No. 5,264,528; U.S. Pat. No. 5,342,727; and Reissue U.S. Pat. No. 34, 122. 
     All of the above-cited prior art and any other references mentioned herein are incorporated herein by reference in their entirety. 
     SUMMARY OF THE INVENTION 
     The present invention provides a unique and novel way of producing vinyl phenol polymers such as p-vinyl phenol polymer [poly(4-hydroxystyrene) (PHS)]. Thus, there is provided a process for preparing polyhydroxystyrene which comprises the steps of (a) heating 4-hydroxyacetophenone (4-HAP) under suitable hydrogenation conditions of temperature and pressure in the presence of a suitable palladium catalyst and for a sufficient period of time to form 4-hydroxyphenylmethylcarbinol (HPMC) [sometimes referred to as 1-(4-hydroxyphenyl)ethanol-( 1,4-HPE)]; (b) heating 4-hydroxyphenylmethylcarbinol under suitable conditions of temperature and pressure and for a sufficient period of time to form said polyhydroxystyrene (PHS). 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     It has unexpectedly been found that PHS can be prepared directly by heating HPMC, with or without a diluent or solvent, for a sufficient period of time under suitable decomposition and polymerization conditions, after HPMC has been directly prepared by hydrogenating 4-HAP. In this manner, PHS can be prepared in a novel two-step process as compared to the five-step procedure of the prior art. Specifically, there is provided a process for preparing polyhydroxystyrene which comprises the steps of (a) heating 4-hydroxyacetophenone under suitable hydrogenation conditions of temperature and pressure in the presence of a suitable palladium catalyst and for a sufficient period of time to form 4-hydroxyphenylmethylcarbinol; and (b) heating 4-hydroxyphenylmethylcarbinol under suitable conditions of temperature and pressure and for a sufficient period of time to form said polyhydroxystyrene. 
     In the overall scheme of preparing PHS in a limited number of process steps, it has been unexpectedly found that the intermediate product, i.e. 4-hydroxymethylcarbinol (HPMC) can be efficiently prepared by hydrogenating 4-hydroxyacetophenone (4-HAP) under certain conditions. Specifically, it has been found that 4-HAP can be heated under suitable hydrogenation conditions of temperature and pressure in the presence of a suitable palladium catalyst and for a sufficient period of time to form HPMC in relatively high yields. The heating is conducted at a temperature of at least about 20° C., preferably from about 20° C. to about 100° C., in the presence of at least a stoichiometric amount of hydrogen and a catalyst selected from the group consisting of Pd/C; Pd/Al 2  O 3  ; Pd/SiO 2  ; and Pd/CaCO 3 . 
     In a preferred embodiment, the reaction is conducted until a substantial completion of hydrogenation is indicated by a lack of H 2  uptake, normally about one to twelve hours. 
     In a preferred embodiment, when Pd/C is used, the reaction proceeds at a pressure of from about 14.7 psig to about 5,000 psig, more preferably at a pressure of from about 50 psig to about 500 psig, and most preferably at a pressure of from about 100 psig to about 400 psig. 
     The hydrogenation conditions also include the use of a suitable solvent/diluent. diluents/solvents which can be used in the present invention include: (a) water; (b) hydrocarbons such as benzene, toluene, xylene, and low-boiling point petroleum fractions; (c) inorganic gases such as carbon monoxide, carbon dioxide, nitrogen, helium, and argon; (d) dipolar aprotic solvents; (e) halogenated hydrocarbons such as chloroform, trichloroethane, or chlorobenzene, etc.; (f) carbon tetrachloride; and (g) mixtures thereof. The dipolar aprotic solvents employed are solvents which have a high dielectric constant and a high dipole moment but no acid hydrogen atoms; for example, such solvents include dimethylsulfoxide (DMSO), acetonitrile, dimethylformamide (DMF), dimethylacetamide, hexamethylphosphoric acid triamide (HMPT), and n-methyl pyrrolidone (NMP). Solvents such as ethanol, methanol, or tetrahydrofuran (THF) may be used in combination with the preceding solvents/diluents. Water, ethanol, methanol, benzene, and toluene (and mixtures thereof) are preferred diluents. The diluents are used in an amount of two to 200 mols, preferably three to twenty moles per mol of 4-HAP. It is to be understood that any diluent may be used under any temperature and reaction conditions so long as the hydrogenation of 4-HAP is effected smoothly. 
     The amount of catalyst employed is that which is catalytically effective in promoting the reaction. Usually, this amount is from about 0.001 weight percent to about 10.0 weight percent based on the weight of the starting material, i.e. 4-HAP. 
     The length of time which this heating/hydrogenation (reaction) step is conducted is not critical and the only requirement is that the heating be conducted for a period sufficient to form HPMC. Generally, this period is at least five minutes and may be as long as 25 hours, generally from about one to about twelve hours. 
     After the hydrogenation of 4-HAP, the end product (HPMC) is recovered from the reaction product and the residual fraction containing any unreacted 4-HAP can be recycled as the starting material for the next cycle of hydrogenation. The end product (HPMC) may be recovered from the reaction product by any method. One example is to recover the HPMC as a polymerized product, i.e. the reaction product is first subjected to a decomposition and a polymerization step [step (b) above] to polymerize the HPMC to the resulting polymerpolyhydroxystyrene (PHS). 
     In step (b) of the present invention, this consists of two phases, i.e. the first phase involves a decomposition of the carbinol in which a dehydration takes place and then the polymerization follows in a second phase. In this first phase, the decomposition takes place at the melting point of the carbinol being used as the starting material. Generally, such temperatures are at least 100° C., preferably from about 125° C. to about 300° C. Any pressure (atmospheric, sub-atmospheric, and/or super-atmospheric) can be used to facilitate this reaction. The reaction can be carried out with or without the use of a solvent (water or organic). The time required for phase one will vary depending, inter alia, upon the starting carbinol used and the temperature. The decomposition of the carbinol results in the formation of a monomer such as HSM. 
     In the second phase (the polymerization phase) of the monomer from phase one (step b) of the present invention thus is carried out at a reaction temperature of at least 70° C., preferably between 70°-300° C., and more preferably between 90°-200° C. The reaction pressure may be sub-atmospheric, atmospheric, or super-atmospheric. 
     The length of time which this heating (polymerization) phase is conducted is not critical and the only requirement is that the heating be conducted for a period sufficient to form PHS. Generally, this period is at least five minutes and may be as long as 25 hours. 
     Diluents/solvents which can be used in this second phase of step (b) of the present invention include: (a) water; (b) hydrocarbons such as benzene, toluene, xylene, and low-boiling point petroleum fractions; (c) inorganic gases such as carbon monoxide, carbon dioxide, nitrogen, helium, and argon; (d) dipolar aprotic solvents; (e) halogenated hydrocarbons such as chloroform, trichloroethane, or chlorobenzene, etc.; (f) carbon tetrachloride; and (g) mixtures thereof. The dipolar aprotic solvents employed are solvents which have a high dielectric constant and a high dipole moment but no acid hydrogen atoms; for example, such solvents include dimethylsulfoxide (DMSO), acetonitrile, dimethylformamide (DMF), dimethylacetamide, hexamethylphosphoric acid triamide (HMPT), and n-methyl pyrrolidone (NMP). Solvents such as ethanol, methanol, or tetrahydrofuran (THF) may be used in combination with the preceding solvents/diluents. Water, ethanol, methanol, benzene, and toluene (and mixtures thereof) are preferred diluents. The diluents are used in an amount of 2 to 200 mols, preferably 3 to 20 mols per mol of HPMC. It is to be understood that any diluent may be used under any temperature and reaction conditions so long as the polymerization of HSM is effected smoothly. 
     In carrying out the present invention, the amount of water, if present in the reaction system, is generally used in a range of 10% to 300% by weight, preferably 20% to 200% by weight, and more preferably, 50% to 100% by weight, based on the amount of the HPMC. 
     It is also within the scope of the present invention to employ polymerization inhibitors or accelerators in order to facilitate the reaction. Any substance may be used as the polymerization accelerator in the present invention if it accelerates or initiates polymerization of HPMC. For example, it is possible to use various polymerization accelerators described in Japanese Patent Publication (examined) Nos. 30123/82 and 47921/82 and Japanese Patent Publication (unexamined) Nos. 44607/82, 44608/82, and 44609/82, etc., all of which are incorporated herein by reference in their entirety. 
     Specific examples of the polymerization accelerators useful in the present invention include (1 ) cation initiators, e.g. (a) inorganic acids such as sulfuric acid, hydrochloric acid, nitric acid, or phosphoric acid, etc.; (b) metal halides such as aluminum chloride, tin tetrachloride, iron chloride, vanadium oxychloride, or boron trifluoride, etc.; (c) complexes such as ether complex of boron trifluoride or phenol complex of boron trifluoride, etc.; (d) aliphatic saturated monocarboxylic acids such as formic aid, bromacetic acid, idoacetic acid, trichloroacetic acid, oxyacetic acid, methoxyacetic acid, mercaptoacetic acid, cyanoacetic acid, propionic acid, 2-oxypropionic acid, n-butyric acid, isobutyric acid, n-valeric acid, isovaleric acid, 4-keto-n-valeric acid, methylethylacetic acid, trimethylacetic acid, caproic acid, heptoic acid, caprylic aid, pelargonic acid, or capric acid, etc.; (e) aliphatic saturated polycarboxylic acids such as oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, tartaric acid, polyacrylic acid, or citric acid, etc.; (f) aliphatic unsaturated monocarboxylic acids such as acrylic acid, crotonic acid, or methacrylic acid, etc.; (g) aliphatic unsaturated polycarboxylic acids such as maleic acid or fumaric acid, etc.; (h) aromatic carboxylic acids such as benzoic acid, hydroxybenzoic acid, methoxybenzoic acid, chlorobenzoic acid, bromobenzoic acid, iodobenzoic acid, cinnamic acid, salicylic acid, toluic acid, phthalic acid, isophthalic acid, terephthalic acid, trimellitic acid, or pyromellitic acid, etc.; or (i) organic sulfonic acids such as methanesulfonic acid; ethanesulfonic acid, benzenesulfonic acid, or toluenesulfonic acid, etc.; and (2) radical initiators, e.g. azoisobutyronitrile, benzoyl peroxide, or ammonium persulfate, etc. 
     Phenol complex of boron trifluoride, sulfuric acid, hydrochloric acid, oxalic acid, phosphoric acid, chloroacetic acid, bromoacetic acid, benzenesulfonic acid, and toluenesulfonic acid are preferred polymerization accelerators. 
     The amount of these polymerization accelerators used varies according to the kind thereof, reacting conditions to be adopted and desired molecular weight of the polymer, etc. However, the amount is generally preferred to be in the range of 0.005 to 10% by weight based on the amount of the HPMC. 
     It is also within the scope of the present invention processes to use a catalyst in order to further facilitate the polymerization reaction. Such catalysts include, without limitation, acids and bases such as H 2  SO 4 , H 3  PO 4 , NaOH, etc. The amount of catalyst employed is any amount which will facilitate (or catalytically effect) the reaction. Such amount will generally be from about 0.00001% by weight to about 2.0% by weight based on the total weight of HPMC employed. 
     After the polymerization of HSM, the end product (PHS) is recovered from the reaction product and the residual fraction containing any unreacted products can be recycled as the starting material for the next cycle. The end product (PHS) may be recovered from the reaction product by any method; for example, it can be separated from the fraction containing the unreacted products by filtration or any other suitable technique. 
     The following specific example is supplied for the purpose of better illustrating the invention. This example is not intended, however, to limit or restrict the scope of the invention in any way and should not be construed as providing conditions, parameters, or values which must be utilized exclusively in order to practice the present invention. 
     EXAMPLE I 
     Hydrogenation of 4-Hydroxyacetophenone 
     4-Hydroxyacetophenone (13.6 g, 0.1 mol) was charged in a 500 ml Zipper autoclave reactor, absolute alcohol (100 ml), and 5% Pd/C (Johnson Matthey&#39;s 21R) (1.2 g) was added. The autoclave was first checked for leaks with 100 psig of nitrogen. The autoclave was later pressurized to 300 psig with hydrogen and stirred at 35° C. for three hours. During this time, 0.095 mole of hydrogen was consumed (95% of the theoretical value). The reaction was vented and the contents filtered through a millipore filter yielding a colorless solution. Concentration of this solution in vacuo gave a solid. Traces of ethanol were removed via azeotropic distillation with toluene to afford a white solid (13.8 g). Liquid chromatographic analysis of the product showed 1,4-HPE (or HPMC) (99.0%), 4-HAP (0.2%), and 4-EP (ethylphenol) (0.8%).  1  H NMR spectrum of the product showed it to be mainly 1,4-HPE, with traces of 4-HAP. 
     EXAMPLES II-XII 
     Using the same procedure set forth in Example I, Examples II-XII were carried out using different reaction conditions as outlined in Table 1. The results are shown in Table 1. 
     
                                           TABLE 1                                 
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ANALYTICAL               REACTION CONDITIONS                              
Example                                                                   
     ex. std.       RUN  4-HAP                                            
                             CATALYST TYPE                                
                                       SOLVENT/                           
                                               H.sub.2                    
No.  HPMC                                                                 
         4-HAP                                                            
             HSM EP TIME (g.)                                             
                             &amp; AMOUNT  AMOUNT  ADDED                      
                                                    COMMENTS              
__________________________________________________________________________
II   84.79                                                                
         11.08                                                            
             0.00                                                         
                 0.57                                                     
                    1.6 HRS                                               
                         12.0                                             
                             0.6 g. 5% Pd/C                               
                                       48 g. MeOH                         
                                               227  45° C., white  
                                                    crystals              
III  74.11                                                                
         0.33                                                             
             0.00                                                         
                 16.00                                                    
                    1.1 HRS                                               
                         18.0                                             
                             1.3 g. 5% Pd/C                               
                                       42 g. MeOH                         
                                               323  55° C., white  
                                                    crystals              
IV   83.33                                                                
         0.00                                                             
             0.00                                                         
                 10.60                                                    
                    3.2 HRS                                               
                         6.0 0.2 g. 5% Pd/C                               
                                       54 g. MeOH                         
                                               108  35° C., white  
                                                    crystals              
V    35.97                                                                
         48.96                                                            
             5.97                                                         
                 2.46                                                     
                    2.0 HRS                                               
                         6.9 0.6 g. 5% Pd/C                               
                                       51 g. EtOH                         
                                               270  35° C., RXN    
                                                    PSI 300,              
                                                    white crystal         
VI   47.30                                                                
         41.48                                                            
             5.22                                                         
                 2.64                                                     
                    1.0 HRS                                               
                         6.0 0.6 g. 5% Pd/C                               
                                       51 g. EtOH                         
                                               **** 35° C., RXN    
                                                    PSI 300,              
                                                    white crystal         
VII  78.95                                                                
         0.00                                                             
             0.00                                                         
                 16.57                                                    
                    3.0 HRS                                               
                         6.0 0.6 g. 5% Pd/C                               
                                       50 g. MeOH                         
                                               **** 35° C., RXN    
                                                    PSI 300,              
                                                    white crystal         
VIII                2.5 HRS                                               
                         6.0 0.6 g. 5% Pd/C                               
                                       45.5 g. MeOH/                      
                                               740  81° C., RXN    
                                                    PSI 300,              
                                       5.6 g. H.sub.2 O                   
                                                    liquid after rotovap  
IX   86.90                                                                
         0.00                                                             
             *** 10.11                                                    
                    2.0 HRS                                               
                         8.0 0.4 g. 5% Pd/C                               
                                       53.4 g. MeOH                       
                                               780  35° C., RXN    
                                                    PSI 300,              
                                                    white crystal         
X    81.36                                                                
         0.86                                                             
             *** 3.55                                                     
                    2.0 HRS                                               
                         8.0 0.2 g. 5% Pd/C                               
                                       53.4 g. MeOH                       
                                               530  35° C., RXN    
                                                    PSI 300,              
                                                    white crystal         
XI   28.52                                                                
         69.22                                                            
             *** 2.26                                                     
                    4.0 HRS                                               
                         20.0                                             
                             1.0 g. 5% Pd/C                               
                                       40 g. MeOH                         
                                               390  35° C., RXN    
                                                    PSI 300,              
                                                    white crystal         
XII                 4.5 HRS                                               
                         20.0                                             
                             1.0 g. 5% Pd/C                               
                                       39.9 g. MeOH                       
                                               1140 35° C., RXN    
                                                    PSI 300,              
                                                    white                 
__________________________________________________________________________
                                                    crystal               
 
    
     EXAMPLES XIII-XVIII 
     Example XIII 
     A 500 ml three neck flask was fitted with a dean stark trap with condenser, mechanical stirrer, and a nitrogen inlet. To the flask was added 4-hydroxyphenylmethylcarbinol-HPMC (34.14 g, 0.25 moles) and the flask was thoroughly purged with nitrogen. The solid was heated to 150° C. with an oil bath for 15 hours. During this time, the solid became a melt and water was released. The melt solidified upon cooling to room temperature, and the solid was dissolved in methanol (100 g). The solution was precipitated into water (800 ml) and the solid was isolated by filtration, washed with water (100 ml), dried (25° C., 100 torr), and weighed (26.0 g, 0.22 moles, 87%). The poly(hydroxystyrene) obtained was soluble in polar organic solvents such as acetone, methanol, tetrahydrofuran, etc. The M m  was 2025 and the M n  was 1328, and the M m  /M n  was 1.53 respectively. 
     Example XIV 
     The same procedure as in Example XIII except phosphoric acid (0.13 g) was used as a dehydration and polymerization catalyst, with 4-hydroxyphenylmethylcarbinol (32 g, 0.23 moles) and the reaction time was twenty hours. The polymer was isolated in a similar manner giving a yield of 81%, a M m  of 3324, a M n  of 1819, and a M m  /M n  of 1.83. 
     Example XV 
     The same procedure as in Example XIV except VA-086 (2,2&#39;-azobis[2-methyl-N-(2-hydroxyethyl)propionamide], Wako Chemicals) (0.13 g) was used as a radical initiator, with 4-hydroxyphenylmethylcarbinol (32.3 g, 0.24 moles) with a reaction time of 22.5 hours. The polymer was isolated in a similar manner giving a yield of 85%, a M m  of 2255, a M n  of 1420, and a M m  /M n  of 1.59. 
     Example XVI 
     To a 100 cc autoclave, 4-hydroxyphenylmethylcarbinol (4.4 g, 0.03 moles) and water (17.6 g) were added. The reactor was thoroughly purged with nitrogen. The mixture was heated to 150° C. for 16 hours. The maximum pressure attained during this time was 170 psi. The reactor was cooled to 40° C. and the reactor was vented and purged with nitrogen. The liquid layer was decanted and the remaining solid was dissolved in methanol (11.7 g). The solution was then precipitated into water (150 ml). The solid was isolated by filtration and washed with water (100 ml), dried (25° C., 100 torr), and weighed (3.28 g, 0.03 moles, 85%). The poly(hydroxystyrene) obtained was soluble in polar organic solvents such as acetone, methanol, tetrahydrofuran, etc. The M m  was 2412 and the M n  was 1443, and the M m  /M n  was 1.67 respectively. 
     Example XVII 
     The same procedure as in Example XVI except polyacrylic acid (1.0 g, 25% PAA in water) was used as a suspension aid and catalyst, with 4-hydroxyphenylmethylcarbinol (9.98 g, 0.07 moles), and water (30.6 g), and the reaction time was 15.5 hours. The maximum pressure attained during this time was 175 psi. The polymer was isolated in a similar manner giving a yield of 78%, a M m  of 4520, a M n  of 2428, and a M m  /M n  of 1.86. 
     Example XVIII 
     The same procedure as in Example XIII except stearic acid (1.0 g) was used as a suspension aid with HPMC (20.4 g, 0.15 moles) and water (60.9 g). The polymer was isolated in a similar manner giving a yield of 81%, a M m  of 1224, a M n  of 817, and a M m  /M n  of 1.50. 
     While the above has been described using 4-hydroxyacetophenone (4-HAP) as the starting material, it is also within the scope of the present invention to use (1 ) other hydroxyacetophenones (wherein the hydroxy substituents are positioned at different locations on the phenyl ring), and (2) substituted hydroxyacetophenones wherein the remaining four hydrogen atoms (on the phenyl ring) are selectively replaced by an R group, said R being selected from the group consisting of (a) C 1  -C 8  alkyl; (b) C 6  H 5  ; (c) halogen (F, Cl, Br, I); (d) hydroxy; and (e) OR where R is the same as defined above. These hydroxyacetophenones and substituted hydroxyacetophenones are all suitable starting materials for use in the present invention process. The resultant intermediate product will be a hydroxyphenylcarbinol or substituted hydroxyphenylcarbinol (&#34;carbinol&#34;). 
     In another facet of the present invention, it was also found that the utilization of a basic material in the hydrogenation step, i.e. step (a) described herein, results in substantial increases in the selectivity to the desired product, i.e. the carbinol. The basic material is selected from the group consisting of (a) alkali metal hydroxides (e.g. NaOH, KOH); (b) alkaline earth metal hydroxides (e.g. CaOH); (c) alkali metal carbonates (e.g. K 2  CO 3 ); (d) alkali metal alkoxides (e.g. NaOCH 3  and KOC(CH 3 ) 3 ); (e) alkali metal organic acid salts (e.g. an ionic organic base such as potassium acetate); and (f) amines (a non-ionic organic base) such as pyridine or a tri-lower-alkylamine (e.g. tripropylamine, trimethylamine, and triethylamine). Such basic material is present in any amount which will achieve the desired end result. Thus, an effective amount will be at least 1 ppm (pan per million), preferably from about 1 ppm to about 10,000 ppm, more preferably from about 25 ppm to about 1,000 ppm. The exact mechanism is not known, however it was surprising to find that such addition of the basic material to the hydrogenation step resulted in significant increases in selectivity. 
     EXAMPLE XIX 
     Synthesis of 4-Hydroxyphenyl Carbinol 
     To a five-gallon stainless steel reactor, a solution of 4-hydroxyacetophenone (2500 g, 18.4 moles) and a 25% solution of sodium methoxide in methanol (39.1 g, 0.26 moles) in methanol (10,000 g, 312.5 moles), and palladium on carbon catalyst (ESCAT 10, 125 g) were charged. The reactor is purged three times with nitrogen (100 psi). Hydrogen is then charged to a pressure of 300 psi and the reactor is heated to 45° C. The temperature is maintained at 45° C. for three hours at a constant hydrogen pressure of 500 psi. The reactor is cooled to 30° C. and then discharged (12,245 g). The analysis of the solution gave a conversion of 97.6% and a selectivity of 96.0% (note Table 2). 
     EXAMPLES XX-XXVIII 
     Example XIX was repeated nine times using the conditions set forth in Table 2. The results are shown in Table 2. 
     The results of these Examples XIX-XXVIII are compared to those of Examples I-XII (i.e. without the use of a basic material) and it can readily be seen that the use of a basic material surprisingly results in a significant increase (e.g. Example VI--47.30% HPMC vs. Example XXI--86.4% HPMC) in selectivity of the HPMC. 
     
                                           TABLE 2                                 
__________________________________________________________________________
     Temp                                                                 
         Pressure                                                         
              %   % Catalyst                                              
Example                                                                   
     °C.                                                           
         psig 4-HAP                                                       
                  vs 4-HAP                                                
                        Conversion                                        
                              Selectivity                                 
                                    Yield                                 
__________________________________________________________________________
XIX  45  500  20  5     97.6  96.0  93.7                                  
XX   35  300  10  3     92.7  96.4  89.4                                  
XXI  55  300  30  3     99.2  86.4  85.7                                  
XXII 35  700  10  7     99.6  93.8  93.4                                  
XXIII                                                                     
     45  500  20  5     99.4  88.8  88.3                                  
XXIV 55  700  10  3     92.1  95.5  88.0                                  
XXV  35  700  30  3     99.4  93.5  92.9                                  
XXVI 35  300  30  7     98.2  98.0  96.2                                  
XXVII                                                                     
     55  300  10  7     99.3  93.9  93.2                                  
XXVIII                                                                    
     45  500  20  5     98.4  96.9  95.3                                  
__________________________________________________________________________
 
    
     Although the invention has been illustrated by the preceding examples, it is not to be construed as being limited thereby; but rather, the invention encompasses the generic area as hereinbefore disclosed. Various modifications and embodiments can be made without departing from the spirit and scope thereof.