Patent Publication Number: US-2010113276-A1

Title: Use of n2-phenylamidines as herbicides

Description:
The invention relates to the technical field of herbicides, in particular to that of herbicides for selectively controlling broad-leaved weeds and weed grasses in crops of useful plants. 
     It is already known from various publications that certain phenylamidines have fungicidal properties. For example, EP 1 150 944 B1 describes fungicidally active N 2 -phenylamidines which carry on the phenyl ring—inter alia—a carbocyclic or heterocyclic radical bonded directly or via a mono- or polyatomic group. 
     The herbicidal effect of such compounds has hitherto not been described. 
     It was an object of the present invention to provide herbicidally effective compounds. 
     It has now been found that N 2 -phenylamidines of formula (I), or salts thereof, have excellent herbicidal properties. 
     The present invention provides the use of compounds of formula (I), or salts thereof, as herbicides 
     
       
         
         
             
             
         
       
     
     in which
     R 2  and R 3 , independently of one another, are each (C 1 -C 6 )-alkyl, (C 3 -C 6 )-cycloalkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, halo-(C 1 -C 6 )-alkyl, halo-(C 2 -C 6 )-alkenyl, halo-(C 2 -C 6 )-alkynyl, (C 1 -C 4 )-alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 4 )-alkoxy-(C 2 -C 6 )-alkenyl or (C 1 -C 4 )-alkoxy-(C 2 -C 6 )-alkynyl, preferably independently of one another in each case (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, halo-(C 1 -C 6 )-alkyl, halo-(C 2 -C 6 )-alkenyl, halo-(C 2 -C 6 )-alkynyl, (C 1 -C 4 )-alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 4 )-alkoxy-(C 2 -C 6 )-alkenyl or (C 1 -C 4 )-alkoxy-(C 2 -C 6 )-alkynyl,   or R 2  and R 3  are together (CH 2 ) 4  or (CH 2 ) 5 ,   or   R 2  and R 3  together with the nitrogen atom to which they are bonded, form a 5- or 6-membered saturated, partially saturated, unsaturated or aromatic ring which comprises k heteroatoms from the group consisting of oxygen, nitrogen and sulfur and which is substituted by p radicals from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, nitro, cyano and hydroxy,   R 4  and R 5  independently of one another are each (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 6 )-cycloalkyl, halogen, cyano, hydroxy, mercapto, acyl, OR a , SR a , Si(R a ) 3  halo-(C 1 -C 6 )-alkyl, (C 1 -C 4 )-alkoxy-(C 1 -C 6 )-alkyl or heterocyclyl bonded to phenyl via a carbon atom,   R a  is (C 1 -C 8 )-alkyl,   m is 1, 2 or 3,   R 6  is in each case carbocyclyl or heterocyclyl substituted by n radicals from the group consisting of halogen, cyano, phenoxy, (C 1 -C 8 )-alkylcarbonyl, (C 1 -C 8 )-alkoxycarbonyl, (C 1 -C 8 )-alkyl, (C 1 -C 8 )-alkoxy, (C 2 -C 8 )-alkenyl, (C 2 -C 8 )-alkynyl and 1,3-dioxolan-2-yl,
       where the specified radicals (C 1 -C 8 )-alkyl, (C 1 -C 8 )-alkoxy, (C 2 -C 8 )-alkenyl and (C 2 -C 8 )-alkynyl are substituted by n radicals from the group consisting of (C 1 -C 8 )-alkoxy, hydroxy and halogen and where   
       1,3-dioxolan-2-yl is substituted by n radicals (C 1 -C 8 )-alkyl,   A is a bond or a divalent group —O—, —S(O) n —, —NR 9 , —CR 7 ═CR 7 —, —C≡C—, -A 1 -, -A 1 -A 1 -, -A 2 -, -A 3 -, -A 1 O—, -A 1 S(O) n —, —OA 2 -, —NR 9 -A 2 -,
       —OA 2 -A 1 -, —OA 2 -CR 7 ═CR 8 —, —S(O) n -A 1 -, —(CH 2 ) 2 —ON═CR 8 —, —X-A 2 -NH—, —C(R 8 )═NO—(C 1 -C 6 )-alkyl or —O(A 1 ) k O—,   
       A 1  is in each case —CHR 7 —,   A 2  is in each case —C(═X)—,   A 3  is —CR 8 ═NO—,   X is in each case independently of the others oxygen or sulfur,   R 7  is—in each case independently of other radicals R 7 -hydrogen, halogen, cyano, (C 1 -C 6 )-alkyl, (C 3 -C 6 )-cycloalkyl, phenyl, halogen, cyano, hydroxy, mercapto, halo-(C 1 -C 6 )-alkyl or (C 1 -C 4 )-alkoxy-(C 1 -C 6 )-alkyl,   R 8  is—in each case independently of other radicals R 8 -hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 1 -C 6 )-alkoxy, (C 1 -C 6 )-alkylthio, (C 3 -C 6 )-cycloalkyl, phenyl, halogen, cyano, hydroxy, mercapto, halo-(C 1 -C 6 )-alkyl, (C 1 -C 4 )-alkoxy-(C 1 -C 6 )-alkyl, carbocyclyl or heterocyclyl,   R 9  is—in each case independently of other radicals R 9 -hydrogen, (C 1 -C 6 )-alkyl, carbocyclyl or heterocyclyl,   k is—in each case independently of other variables k −1, 2 or 3,   n is—in each case independently of other variables n −0, 1 or 2, and   p is 0, 1, 2 or 3.   

     The linkage of A with R 6  and the phenyl ring should be understood as meaning that R 6  is bonded on the right-hand side and the phenyl ring is bonded on the left-hand side of A. 
     The compounds of formula (I) can also be present in salt form, for example as hydrochloride or in the form of other acid adducts. These salts are likewise suitable as herbicides and are intended to be encompassed by formula (I). Preference is given to hydrochlorides, hydrobromides, trifluoroacetates, acetates and trifluoro-methanesulfonates. 
     In formula (I) and all of the formulae below, alkyl radicals having more than two carbon atoms may be straight-chain or branched. Alkyl radicals are, for example, methyl, ethyl, n- or isopropyl, n-, iso-, t- or 2-butyl, pentyl, hexyl, such as n-hexyl, isohexyl and 1,3-dimethylbutyl. Halogen is fluorine, chlorine, bromine or iodine. 
     If a group is substituted by radicals more than once, then this is to be understood as meaning that this group is substituted by one or more identical or different of the specified radicals. 
     Heterocyclyl is a saturated, unsaturated or heteroaromatic cyclic radical; it contains one or more heteroatoms in the ring, preferably from the group consisting of N, O and S; preferably, it is an aliphatic heterocyclyl radical having 3 to 7 ring atoms or a heteroaromatic radical having 5 or 6 ring atoms and comprises 1, 2 or 3 heteroatoms. 
     The heterocyclic radical can be, for example, a heteroaromatic radical or ring (heteroaryl), such as, for example, a mono-, bi- or polycyclic aromatic system in which at least 1 ring comprises one or more heteroatoms, for example pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, thienyl, thiazolyl, oxazolyl, furyl, pyrrolyl, pyrazolyl and imidazolyl, or is a partially or completely hydrogenated radical such as oxiranyl, pyrrolidyl, piperidyl, piperazinyl, dioxolanyl, morpholinyl, tetrahydrofuryl. Suitable substituents for a substituted heterocyclic radical are the substituents given below, additionally also oxo. The oxo group can also occur on the hetero ring atoms, which can exist in various oxidation states, e.g. in the case of N and S. 
     Carbocyclyl is a saturated, unsaturated or aromatic cyclic radical which comprises exclusively carbon atoms in the ring; for example cycloalkyl, cycloalkenyl, phenyl and naphthyl. Suitable substituents for carbocyclyl are the substituents specified below, additionally also oxo. The oxo group can also occur on the hetero ring atoms, which can exist in various oxidation states, e.g. in the case of N and S. 
     Cycloalkyl is a carbocyclic, saturated ring system with three to nine carbon atoms, e.g. cyclopropyl, cyclopentyl or cyclohexyl. 
     If the term acyl radical is used in this description, this means the radical of an organic acid which is produced formally by eliminating an OH group from the organic acid, e.g. the radical of a carboxylic acid and radicals of acids derived therefrom such as thiocarboxylic acid, optionally N-substituted iminocarboxylic acids or the radicals of carbonic acid monoesters, optionally N-substituted carbamic acids, sulfonic acids, sulfinic acids, phosphonic acids, phosphinic acids. 
     An acyl radical is preferably formyl or acyl from the group consisting of CO—R z , CS—R z , CO—OR z , CS—OR z , CS—SR z , SOR z  or SO 2 R z , where R z  is in each case a C 1 -C 10 -hydrocarbon radical such as C 1 -C 10 -alkyl or phenyl, which is unsubstituted or substituted, e.g. by one or more substituents from the group consisting of halogen, such as F, Cl, Br, I, alkoxy, haloalkoxy, hydroxy, amino, nitro, cyano or alkylthio, or R z  is aminocarbonyl or aminosulfonyl, where the two last-mentioned radicals are unsubstituted, N-monosubstituted or N,N-disubstituted, e.g. by substituents from the group consisting of alkyl or aryl. 
     Acyl is, for example, formyl, haloalkylcarbonyl, alkylcarbonyl such as (C 1 -C 4 )-alkylcarbonyl, phenylcarbonyl, where the phenyl ring may be substituted, or alkyloxycarbonyl, such as (C 1 -C 4 )-alkyloxycarbonyl, phenyloxycarbonyl, benzyl-oxycarbonyl, alkylsulfonyl, such as (C 1 -C 4 )-alkylsulfonyl, alkylsulfinyl, such as C 1 -C 4 -(alkylsulfinyl), N-alkyl-1-iminoalkyl, such as N—(C 1 -C 4 )-1-imino-(C 1 -C 4 )-alkyl and other radicals of organic acids. 
     The compounds of formula (I) and salts thereof can be present as stereoisomers depending on the type and linkage of the substituents. If, for example, one or more asymmetric carbon atoms are present, then enantiomers and diastereomers can arise. Stereoisomers can be obtained from mixtures produced during the preparation by customary separation methods, for example by chromatographic separation methods. Stereoisomers can likewise be selectively prepared by using stereoselective reactions using optically active starting materials and/or auxiliaries. The invention also relates to all stereoisomers and mixtures thereof which are encompassed by formula (I) but not specifically defined. In particular, it relates to the E/Z isomers, both their mixture and the individual isomers. 
     Preference is given to compounds of formula (I), in which
     R 2  and R 3  independently of one another, are in each case (C 1 -C 6 )-alkyl, cyclopropyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, halo-(C 1 -C 6 )-alkyl, halo-(C 2 -C 6 )-alkenyl, halo-(C 2 -C 6 )-alkynyl, (C 1 -C 4 )-alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 4 )-alkoxy-(C 2 -C 6 )-alkenyl or (C 1 -C 4 )-alkoxy-(C 2 -C 6 )-alkynyl, or preferably independently of one another are in each case (C 1 -C 6 )-alkenyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, halo-(C 1 -C 6 )-alkyl, halo-(C 2 -C 6 )-alkenyl, halo-(C 2 -C 6 )-alkynyl, (C 1 -C 4 )-alkoxy-(C 1 -C 6 )-alkyl, (C 1 -C 4 )-alkoxy-(C 2 -C 6 )-alkenyl or (C 1 -C 4 )-alkoxy-(C 2 -C 6 )-alkynyl, or are together (CH 2 ) 4  or (CH 2 ) 5 ,   R 4  is (C 1 -C 6 )-alkyl, halo-(C 1 -C 6 )-alkyl or (C 1 -C 4 )-alkoxy-(C 1 -C 6 )-alkyl,   R 5  is halogen, (C 1 -C 6 )-alkyl, halo-(C 1 -C 6 )-alkyl or (C 1 -C 4 )-alkoxy-(C 1 -C 6 )-alkyl,   A is a bond, —O—, —S—, —CH 2 CH 2 —, —CH 2 —, —OCH 2 —, —CH═CH—, —C≡C—, —NH—CO—, —N(CH 3 )—, NH— or —O—CO—NH—,   R 6  is phenyl or naphthyl substituted by n radicals from the group consisting of halogen, cyano, phenoxy, (C 1 -C 4 )-alkylcarbonyl, (C 1 -C 4 )-alkyl, (C 1 -C 6 )-alkoxy, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl and 1,3-dioxolan-2-yl, where the specified radicals (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkoxy, (C 2 -C 6 )-alkenyl and (C 2 -C 6 )-alkynyl are substituted by n radicals from the group consisting of (C 1 -C 4 )-alkoxy, hydroxy and halogen
       and where 1,3-dioxolan-2-yl is substituted by n radicals (C 1 -C 5 )-alkyl, or R 6  is heterocyclyl substituted by n radicals from the group consisting of halogen, (C 1 -C 6 )-alkyl, halo-(C 1 -C 4 )-alkoxy and halo-(C 1 -C 4 )-alkyl.   
       m is 1 and   n is—in each case independently of other variables n −0, 1 or 2.   

     Particular preference is given to compounds of formula (I), in which
     R 2  is methyl,   R 3  is methyl, ethyl, cyclopropyl or isopropyl, or,
       R 2  and R 3  are together (CH 2 ) 4  or (CH 2 ) 5 ,   
       R 4  is methyl,   R 5  is methyl or chlorine,   A is a bond, —O—, —S—, —CH 2 —CH 2 —, —CH 2 —, —OCH 2 — or —CH═CH—, in particular a bond or —O—,   R 6  is phenyl or naphthyl substituted by n radicals from the group consisting of halogen, cyano, phenoxy, (C 1 -C 4 )-alkylcarbonyl, (C 1 -C 4 )-alkyl, (C 1 -C 6 )-alkoxy, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl and 1,3-dioxolan-2-yl, where the specified radicals (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkoxy, (C 2 -C 6 )-alkenyl and (C 2 -C 6 )-alkynyl are substituted by n radicals from the group consisting of (C 1 -C 4 )-alkoxy, hydroxy and halogen and where
       1,3-dioxolan-2-yl is substituted by n radicals (C 1 -C 8 )-alkyl, or R 6  is pyridinyl, thiadiazolyl or thiazolyl substituted by n radicals from the group consisting of halogen, (C 1 -C 6 )-alkyl, halo-(C 1 -C 4 )-alkoxy and halo-(C 1 -C 4 )-alkyl,   
       m is 1, and   n is—in each case independently of other variables n −0, 1 or 2.   

     The compounds of formula (I) are known from EP 1 150 944 B1 and are accessible by the preparation methods described therein. 
     The compounds of formula (I) have excellent herbicidal effectiveness against a broad spectrum of economically important mono- and dicotyledonous harmful plants. Perennial broad-leaved weeds which are difficult to control and which sprout from rhizomes, root stocks or other permanent organs, are readily attacked by the active ingredients. In this connection, it is generally unimportant whether the substances are applied in the presowing, preemergence or postemergence method. Specifically, by way of example mention may be made of a number of representatives of the mono- and dicotyledonous broad-leaved weed flora which can be controlled by the compounds of formula (I) without any intention of restriction to certain types as a result of the naming. On the side of the monocotyledonous broad-leaved weed species are, for example,  Avena, Lolium, Alopecurus, Phalaris, Echinochloa, Digitaria, Setaria  and  Cyperus  species from the annual group and on the side of the perennial species  Agropyron, Cynodon, Imperata  and  Sorghum  and also perennial  Cyperus  species are readily attacked. 
     In the case of dicotyledonous broad-leaved weed species, the activity spectrum extends to species such as, for example,  Galium, Viola, Veronica, Lamium, Stellaria, Amaranthus, Sinapis, Ipomoea, Sida, Matricaria  and  Abutilon  on the annual side, and also  Convolvulus, Cirsium, Rumex  and  Artemisia  in the case of the perennial broad-leaved weeds. Under specific crop conditions, harmful plants that occur in rice, such as, for example,  Echinochloa, Sagittaria, Alisma, Eleocharis, Scirpus  and  Cyperus , are likewise controlled in an excellent manner by the compounds of formula (I). If the compounds of formula (I) are applied to the soil surface prior to germination, then either the emergence of the broad-leaved weed seedlings is completely prevented or the broad-leaved weeds grow up to the seed leaf stage, but then stop growing and finally die off after the course of three to four weeks. In the case of application of the active ingredients to the green parts of the plant in the postemergence method, a drastic stop in growth likewise occurs very rapidly following treatment and the broad-leaved weed plants remain in the growth stage present at the time of application or die off altogether after a certain time, meaning that in this way a broad-leaved weed competition harmful for the crop plants is eliminated very early on and in a lasting manner. In particular, the compounds of formula (I) exhibit an excellent effect against  Apera spica venti, Chenopodium album, Lamium purpureum, Polygonum convulvulus, Stellaria media, Veronica hederifolia, Veronica persica, Viola tricolor  and also against species of  Amaranthus, Galium  and  Kochia.    
     Although the compounds of formula (I) have excellent herbicidal activity toward mono- and dicotyledonous broad-leaved weeds, crop plants of economically important crops such as, for example, wheat, barley, rye, rice, corn, sugarbeet, cotton and soybeans, are damaged only negligibly, if at all. In particular, they have excellent compatibility in corn, rice, cereals and soybeans. These compounds are therefore very readily suitable for selectively controlling undesired plant growth in agricultural useful plantations or in ornamental plantations. 
     On account of their herbicidal properties, these compounds can also be used for controlling harmful plants in crops of known or still developing genetically modified plants. The transgenic plants are usually characterized by particularly advantageous properties, for example by resistances to certain pesticides, primarily certain herbicides, resistances to plant diseases or pathogens of plant diseases such as certain insects or microorganisms such as fungi, bacteria or viruses. Other particular properties relate, for example, to the harvest material with regard to amount, quality, storability, composition and special ingredients. For example, transgenic plants with increased starch content or modified quality of the starch or those with a different fatty acid composition of the harvest material are known. 
     Preferably, the application of the compounds of formula (I) or salts thereof is in economically important transgenic crops of useful plants and ornamental plants, e.g. of cereals such as wheat, barley, rye, oats, millet, rice, manioc and corn and also in crops of sugarbeet, cotton, soybeans, rape, potatoes, tomatoes, peas and other vegetable varieties. The compounds of formula (I) can preferably be used as herbicides in useful plant crops which are resistant to the phytotoxic effects of the herbicides and/or have been rendered resistant by means of genetic engineering, in particular soybeans and corn. 
     Conventional methods for producing new plants which have modified properties compared to existing plants consist, for example, in classical cultivation methods and the production of mutants. Alternatively, new plants with modified properties can be produced using genetic engineering methods (see e.g. EP-A-0221044, EP-A-0131624). For example, in several cases the following have been described:
         genetic modifications of crop plants for the purpose of modifying the starch synthesized in the plants (e.g. WO 92/11376, WO 92/14827, WO 91/19806),   transgenic crop plants which are resistant to certain herbicides of the glufosinate type (e.g. EP-A 0 242 236, EP-A 0 242 246) or glyphosate type (WO 92/00377) or the sulfonylurea type (EP-A-0257993, U.S. Pat. No. 5,013,659),   transgenic crop plants, for example cotton, with the ability to produce  Bacillus thuringiensis  toxins (Bt toxins) which make the plants resistant to certain pests (EP-A 0 142 924, EP-A 0 193 259).   transgenic crop plants with a modified fatty acid composition (WO 91/13972).       

     Numerous molecular biological techniques with which new transgenic plants with modified properties can be produced are known in principle, see e.g. Sambrook et al., 1989, Molecular Cloning, A Laboratory Manual, 2nd edition, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.; or Winnacker “Gene and Klone [Genes and Clones]”, VCH Weinheim 2nd edition, 1996 or Christou, “Trends in Plant Science” 1 (1996) 423-431). For genetic manipulations of this type, nucleic acid molecules can be introduced into plasmids which permit a mutagenesis or a sequence modification through recombination of DNA sequences. With the help of the aforementioned standard methods it is possible, for example, to undertake base exchange, remove part sequences or add natural or synthetic sequences. To join the DNA fragments with one another, adapters or linkers can be attached to the fragments. 
     The production of plant cells with reduced activity of a gene product can be achieved, for example, through the expression of at least one corresponding antisense-RNA, of a sense-RNA for achieving a cosuppression effect or the expression of at least one correspondingly constructed ribozyme which cleaves specific transcripts of the aforementioned gene product. 
     For this, firstly DNA molecules can be used which include the entire coding sequence of a gene product including any flanking sequences present, and also DNA molecules which only include parts of the coding sequence, in which case it is necessary for these parts to be long enough to bring about an antisense effect in the cells. It is also possible to use DNA sequences which have a high degree of homology to the coding sequences of a gene product, but are not completely identical. 
     During the expression of nucleic acid molecules in plants, the synthesized protein can be localized in any desired compartment of the plant cell. However, in order to achieve localization in a specific compartment, the coding region can, for example, be linked to DNA sequences which ensure localization in a specific compartment. Sequences of this type are known to the person skilled in the art (see, for example, Braun et al., EMBO J. 11 (1992), 3219-3227; Wolter et al., Proc. Natl. Acad. Sci. USA 85 (1988), 846-850; Sonnewald et al., Plant J. 1 (1991), 95-106). 
     The transgenic plant cells can be regenerated by known techniques to give whole plants. The transgenic plants may in principle be plants of any desired plant species, i.e. both monocotyledonous and also dicotyledonous plants. Thus, transgenic plants are obtainable which have modified properties through overexpression, suppression or inhibition of homologous (=natural) genes or gene sequences or expression of heterologous (=foreign) genes or gene sequences. 
     When using the compounds of formula (I) in transgenic crops, besides the effects against harmful plants that are observed in other crops, effects often arise which are specific to the application in the particular transgenic crop, for example a modified or specifically expanded broad-leaved weed spectrum which can be controlled, modified application amounts which can be used for the application, preferably good combineability with the herbicides against which the transgenic crop is resistant, and also influencing of growth and yield of the transgenic crop plants. The invention therefore also provides the use of the compounds of formula (I) as herbicides for controlling harmful plants in transgenic crop plants. 
     Moreover, the compounds of formula (I) have excellent growth-regulatory properties in crop plants. They intervene to regulate the plant&#39;s own metabolism and can therefore be used for the targeted influencing of plant ingredients and for ease of harvesting such as, for example, by triggering desiccation and stunted growth. Furthermore, they are also suitable for generally controlling and inhibiting undesired vegetative growth without killing off the plants at the same time. An inhibition of the vegetative growth plays a great role for many mono- and dicotyledonous crops since this allows lodging to be reduced or completely prevented. 
     The compounds of formula (I) can be formulated in different ways to give herbicidal compositions according to which biological and/or chemical-physical parameters are prescribed. Suitable formulation possibilities are, for example: spray powders (WP), water-soluble powders (SP), water-soluble concentrates, emulsifiable concentrates (EC), emulsions (EW), such as oil-in-water and water-in-oil emulsions, sprayable solutions, suspension concentrates (SC), dispersions based on oil or water, oil-miscible solutions, dusting agents (DP), capsule suspensions (CS), seed dressings, granules for scattering and soil application, granules (GR) in the form of microgranules, spray granules, coated granules and adsorption granules, water-dispersible granules (WG), water-soluble granules (SG), ULV formulations, microcapsules and waxes. These individual formulation types are known in principle and are described, for example, in: Winnacker-Küchler, “Chemische Technologie [Chemical Technology]”, volume 7, C. Hanser Verlag Munich, 4th edition, 1986, Wade van Valkenburg, “Pesticide Formulations”, Marcel Dekker, N.Y., 1973; K. Martens, “Spray Drying” Handbook, 3rd Ed., 1979, G. Goodwin Ltd. London. Such herbicidal compositions are likewise provided by the invention. 
     The necessary formulation auxiliaries such as inert materials, surfactants, solvents and further additives are likewise known and are described, for example, in: Watkins, “Handbook of Insecticide Dust Diluents and Carriers”, 2nd Ed., Darland Books, Caldwell N.J., H. v. Olphen, “Introduction to Clay Colloid Chemistry”; 2nd Ed., J. Wiley &amp; Sons, N.Y.; C. Marsden, “Solvents Guide”; 2nd Ed., Interscience, N.Y. 1963; McCutcheon&#39;s “Detergents and Emulsifiers Annual”, MC Publ. Corp., Ridgewood N.J.; Sisley and Wood, “Encyclopedia of Surface Active Agents”, Chem. Publ. Co. Inc., N.Y. 1964; Schönfeldt, “Grenzflächenaktive Äthylenoxidaddukte [Surface-active ethylene oxide adducts]”, Wiss. Verlagsgesell., Stuttgart 1976; Winnacker-Küchler, “Chemische Technologie [Chemical Technology]”, volume 7, C. Hanser Verlag Munich, 4th edition, 1986. 
     Spray powders are preparations which can be dispersed uniformly in water and which, besides the active ingredient, apart from a diluent or inert substance, also comprise surfactants of ionic and/or nonionic type (wetting agent, dispersant), e.g. polyoxyethylated alkylphenols, polyoxethylated fatty alcohols, polyoxethylated fatty amines, fatty alcohol polyglycol ether sulfates, alkanesulfonates, alkylbenzene-sulfonates, sodium 2,2′-dinaphthylmethane-6,6′-disulfonate, sodium lignosulfonate, sodium dibutylnaphthalenesulfonate and also sodium oleoylmethyltaurate. To prepare the spray powders, the herbicidal active ingredients are finely ground, for example in customary apparatuses such as hammer mills, blower mills and air-jet mills and are mixed simultaneously or subsequently with the formulation auxiliaries. 
     Emulsifiable concentrates are prepared by dissolving the active ingredient in an organic solvent, e.g. butanol, cyclohexanone, DMF, xylene or else higher-boiling aromatics or hydrocarbons or mixtures of these solvents with the addition of one or more surfactants of ionic and/or nonionic type (emulsifiers). Emulsifiers which can be used are, for example: alkylarylsulfonic calcium salts, such as Ca dodecylbenzenesulfonate or nonionic emulsifiers such as fatty acid polyglycol esters, alkylaryl polyglycol ethers, fatty alcohol polyglycol ethers, propylene oxide-ethylene oxide condensation products, alkyl polyethers, sorbitan esters such as, for example, sorbitan fatty acid esters and polyoxethylene sorbitan esters such as, for example, polyoxyethylene sorbitan fatty acid esters. 
     Dusting agents are obtained by grinding the active ingredient with finely divided solid substances, e.g. talc, natural clays, such as kaolin, bentonite and pyrophyllite, or diatomaceous earth. Suspension concentrates may be water-based or oil-based. They can be prepared, for example, by wet grinding by means of standard commercial bead mills and if appropriate addition of surfactants, as are listed, for example, above in connection with the other types of formulation. 
     Emulsions, e.g. oil-in-water emulsions (EW), can be prepared, for example, by means of stirrers, colloid mills and/or static mixers using aqueous organic solvents and if appropriate surfactants, as have already been listed above, for example, in connection with the other types of formulation. 
     Granules can be prepared either by atomizing the active ingredient onto granulated inert material that is capable of adsorption or by applying active ingredient concentrates by means of adhesives, e.g. polyvinyl alcohol, polyacrylic sodium or else mineral oils, onto the surface of carrier substances such as sand, kaolinites or of granulated inert material. Suitable active ingredients can also be granulated in the manner customary for producing fertilizer granules—if desired in a mixture with fertilizers. Water-dispersible granules are usually prepared by customary methods such as spray-drying, fluidized-bed granulation, pan granulation, mixing using high-speed mixers and extrusion without solid inert material. 
     For the preparation of pan, fluidized-bed, extruder and spray granules, see, for example, methods in “Spray-Drying Handbook” 3rd ed., 1979, G. Goodwin Ltd., London; J. E. Browning, “Agglomeration”, Chemical and Engineering 1967, pages 147 if; “Perry&#39;s Chemical Engineer&#39;s Handbook”, 5th Ed., McGraw-Hill, New York 1973, pp. 8-57. For further details relating to the formulation of crop protection compositions, see, for example, G. C. Klingman, “Weed Control as a Science”, John Wiley and Sons, Inc., New York, 1961, pages 81-96 and J. D. Freyer, S. A. Evans, “Weed Control Handbook”, 5th Ed., Blackwell Scientific Publications, Oxford, 1968, pages 101-103. 
     The agrochemical preparations generally comprise 0.1 to 99% by weight, in particular 0.1 to 95% by weight, of active ingredient of formula (I). In spray powders, the active ingredient concentration is, for example, about 10 to 90% by weight, the remainder to 100% by weight consists of customary formulation constituents. In the case of emulsifiable concentrates, the active ingredient concentration can be about 1 to 90% by weight, preferably 5 to 80% by weight. Dust-like formulations comprise 1 to 30% by weight of active ingredient, preferably at most 5 to 20% by weight of active ingredient, sprayable solutions comprise about 0.05 to 80% by weight, preferably 2 to 50% by weight, of active ingredient. In the case of water-dispersible granules, the active ingredient content depends partly on whether the active compound is present in liquid or solid form and which granulation auxiliaries, fillers, etc. are used. In the case of the water-dispersible granules, the content of active ingredient is, for example, between 1 and 95% by weight, preferably between 10 and 80% by weight. 
     In addition, the specified active ingredient formulations optionally comprise the adhesives, wetting agents, dispersants, emulsifiers, penetration agents, preservatives, antifreezes and solvents, fillers, carriers and dyes, antifoams, evaporation inhibitors and agents which influence the pH and the viscosity that are customary in each case. 
     On the basis of these formulations, it is also possible to prepare combinations with other pesticide substances, such as, for example, insecticides, acaricides, herbicides, fungicides, and also with safeners, fertilizers and/or growth regulators, e.g. in the form of a finished formulation or as tank mix. 
     Combination partners which can be used for the compounds of formula (I) in mixture formulations or in the tank mix are, for example, known active ingredients, as are described, for example, in Weed Research 26, 441-445 (1986) or “The Pesticide Manual”, 13th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2003 and literature cited therein. Known herbicides which can be combined with the compounds of formula (I) are, for example, the following active ingredients (note: the compounds are designated either with the “common name” in accordance with the International Organization for Standardization (ISO) or with the chemical name, optionally together with a customary code number): 
     acetochlor; acifluorfen; aclonifen; AKH 7088, i.e. [[[1-[5-[2-chloro-4-(trifluoromethyl)-phenoxy]-2-nitrophenyl]-2-methoxyethylidene]amino]oxy]acetic acid and its methyl ester; alachlor; alloxydim; ametryn; amicarbazone; amidosulfuron; amitrol; AMS, i.e. ammonium sulfamate; anilofos; asulam; atrazin; azimsulfuron (DPX-A8947); aziprotryn; barban; BAS 516H, i.e. 5-fluoro-2-phenyl-4H-3,1-benzoxazin-4-one; benazolin; benfluralin; benfuresate; bensulfuron-methyl; bensulide; bentazone; benzfenap; benzofluor; benzoylprop-ethyl; benzthiazuron; bialaphos; bifenox; bromacil; bromobutide; bromofenoxim; bromoxynil; bromuron; buminafos; busoxinone; butachlor; butamifos; butenachlor; buthidazole; butralin; butylate; cafenstrole (CH-900); carbetamide; cafentrazone (ICI-A0051); CDAA, i.e. 2-chloro-N,N-di-2-propenylacetamide; CDEC, i.e. 2-chloroallyl diethyldithiocarbamate; chlomethoxyfen; chloramben; chlorazifop-butyl, chlormesulon (ICI-A0051); chlorbromuron; chlorbufam; chlorfenac; chlorflurecol-methyl; chloridazon; chlorimuron ethyl; chlornitrofen; chlorotoluron; chloroxuron; chlorpropham; chlorsulfuron; chlorthal-dimethyl; chlorthiamid; cinmethylin; cinosulfuron; clethodim; clodinafop and ester derivatives thereof (e.g. clodinafop-propargyl); clomazone; clomeprop; cloproxydim; clopyralid; cumyluron (JC 940); cyanazine; cycloate; cyclosulfamuron (AC 104); cycloxydim; cycluron; cyhalofop and ester derivatives thereof (e.g. butyl ester, DEH-112); cyperquat; cyprazine; cyprazole; daimuron; 2,4-DB; dalapon; desmedipham; desmetryn; di-allate; dicamba; dichlobenil; dichlorprop; diclofop and esters thereof such as diclofop-methyl; diethatyl; difenoxuron; difenzoquat; diflufenican; dimefuron; dimethachlor; dimethametryn; dimethenamid (SAN-582H); dimethazone, clomazon; dimethipin; dimetrasulfuron, dinitramine; dinoseb; dinoterb; diphenamid; dipropetryn; diquat; dithiopyr; diuron; DNOC; eglinazine-ethyl; EL 77, i.e. 5-cyano-1-(1,1-dimethylethyl)-N-methyl-1H-pyrazole-4-carboxamide; endothal; EPTC; esprocarb; ethalfluralin; ethametsulfuron-methyl; ethidimuron; ethiozin; ethofumesate; F5231, i.e. N-[2-chloro-4-fluoro-5-[4-(3-fluoropropyl)-4,5-dihydro-5-oxo-1H-tetrazol-1-yl]phenyl]ethanesulfonamide; ethoxyfen and esters thereof (e.g. ethyl ester, HN-252); etobenzanid (HW 52); fenoprop; fenoxan, fenoxapropand fenoxaprop-P and esters thereof, e.g. fenoxaprop-P-ethyl and fenoxaprop-ethyl; fenoxydim; fenuron; flamprop-methyl; flazasulfuron; fluazifop and fluazifop-P and esters thereof, e.g. fluazifop-butyl and fluazifop-P-butyl; fluchloralin; flumetsulam; flumeturon; flumiclorac and esters thereof (e.g. pentyl ester, S-23031); flumioxazin (S-482); flumipropyn; flupoxam (KNW-739); fluorodifen; fluoroglycofen-ethyl; flupropacil (UBIC-4243); fluridone; fluorochloridone; fluoroxypyr; flurtamone; fomesafen; fosamine; furyloxyfen; glufosinate; glyphosate; halosafen; halosulfuron and esters thereof (e.g. methyl ester, NC-319); haloxyfop and esters thereof; haloxyfop-P (=R-haloxyfop) and esters thereof; hexazinone; imazapyr; imazamethabenz-methyl; imazaquin and salts such as the ammonium salt; ioxynil; imazethamethapyr; imazethapyr; imazosulfuron; isocarbamid; isopropalin; isoproturon; isouron; isoxaben; isoxapyrifop; karbutilate; lactofen; lenacil; linuron; MCPA; MCPB; mecoprop; mefenacet; mefluidid; metamitron; metazachlor; metham; methabenzthiazuron; methazole; methoxyphenone; methyldymron; metabenzuron, methobenzuron; metobromuron; metolachlor; metosulam (XRD 511); metoxuron; metribuzin; metsulfuron-methyl; MH; molinate; monalide; monolinuron; monuron; monocarbamide dihydrogensulfate; MT 128, i.e. 6-chloro-N-(3-chloro-2-propenyl)-5-methyl-N-phenyl-3-pyridazinamine; MT 5950, i.e. N-[3-chloro-4-(1-methylethyl)phenyl]-2-methylpentanamide; naproanilide; napropamide; naptalam; NC 310, i.e. 4-(2,4-dichlorobenzoyl)-1-methyl-5-benzyloxypyrazole; neburon; nicosulfuron; nipyraclophen; nitralin; nitrofen; nitrofluorfen; norflurazon; orbencarb; oryzalin; oxadiargyl (RP-020630); oxadiazon; oxyfluorfen; paraquat; pebulate; pendimethalin; perfluidone; phenisopham; phenmedipham; picloram; pinoxaden; piperophos; piributicarb; pirifenop-butyl; pretilachlor; primisulfuron-methyl; procyazine; prodiamine; profluralin; proglinazine-ethyl; prometon; prometryn; propachlor; propanil; propaquizafop and esters thereof; propazine; propham; propisochlor; propoxycarbazone; propyzamide; prosulfalin; prosulfocarb; prosulfuron (CGA-152005); prynachlor; pyraclonil, pyrazolinate; pyrazon; pyrazosulfuron-ethyl; pyrazoxyfen; pyridate; pyrithiobac (KIH-2031); pyroxofop and esters thereof (e.g. propargyl ester); quinclorac; quinmerac; quinofop and ester derivatives thereof, quizalofop and quizalofop-P ester derivatives thereof, e.g. quizalofop-ethyl; quizalofop-P-tefuryl and -ethyl; renriduron; rimsulfuron (DPX-E 9636); S 275, i.e. 2-[4-chloro-2-fluoro-5-(2-propynyloxy)phenyl]-4,5,6,7-tetrahydro-2H-indazole; secbumeton; sethoxydim; siduron; simazine; simetryn; SN 106279, i.e. 2-[[7-[2-chloro-4-(trifluoromethyl)phenoxy]-2-naphthalenyl]oxy]propanoic acid and methyl ester; sulfentrazon (FMC-97285, F-6285); sulfazuron; sulfometuron-methyl; sulfosate (ICI-A0224); TCA; tebutam (GCP-5544); tebuthiuron; terbacil; terbucarb; terbuchlor; terbumeton; terbuthylazine; terbutryn; TFH 450, i.e. N,N-diethyl-3-[(2-ethyl-6-methylphenyl)sulfonyl]-1H-1,2,4-triazole-1-carboxamide; thenylchlor (NSK-850); thiazafluoron; thiazopyr (Mon-13200); thidiazimin (SN-24085); thiobencarb; thifensulfuron-methyl; tiocarbazil; tralkoxydim; tri-allate; triasulfuron; triazofenamide; tribenuron-methyl; triclopyr; tridiphane; trietazine; trifluralin; triflusulfuron and esters (e.g. methyl ester, DPX-66037); trimeturon; tsitodef; vernolate; WL 110547, i.e. 5-phenoxy-1-[3-(trifluoromethyl)phenyl]-1H-tetrazole; UBH-509; D-489; LS 82-556; KPP-300; NC-324; NC-330; KH-218; DPX-N8189; SC-0774; DOWCO-535; DK-8910; V-53482; PP-600; MBH-001; KIH-9201; ET-751; KIH-6127; KIH-2023 and KIH-485. 
     For use, the formulations present in standard commercial form are optionally diluted in the usual manner, e.g. in the case of spray powders, emulsifiable concentrates, dispersions and water-dispersible granules by means of water. Dust-like preparations, soil and scatter granules and also sprayable solutions are usually not diluted with further inert substances prior to use. The required rate of application of the compounds of formula (I) varies inter alia with the external conditions such as temperature, humidity, type of herbicide used. It can vary within wide limits, e.g. between 0.001 and 1.0 kg/ha or more active substance, but is preferably between 5 and 750 g/ha, in particular between 5 and 250 g/ha. 
    
    
     The examples below illustrate the invention. 
     The abbreviations used here mean: 
     
       
         
           
               
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 iPr = isopropyl 
                 cPr = cyclopropyl 
                 Pr = propyl 
               
               
                   
                 Et = ethyl 
                 Me = methyl 
                 Ph = phenyl 
               
               
                   
                 tBu = tertiary-butyl 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Compounds of formula (Ia) [═ compounds according to the invention of 
               
               
                 general formula (I) in which R 4  is methyl] 
               
            
           
           
               
               
            
               
                   
                 (Ia) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 No. 
                 R 2   
                 R 3   
                 R 5   
                 A 
                 R 6   
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1 
                 Me 
                 Me 
                 Me 
                 O 
                 3-Br-5-F-Phenyl 
               
               
                 2 
                 Me 
                 Et 
                 Me 
                 O 
                 3-Br-5-F-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 3 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-Br-5-F-Phenyl 
               
               
                 4 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-Br-5-F-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 5 
                 Me 
                 Me 
                 Me 
                 S 
                 3-Br-5-F-Phenyl 
               
               
                 6 
                 Me 
                 Et 
                 Me 
                 S 
                 3-Br-5-F-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 7 
                 (CH 2 ) 4   
                 Me 
                 S 
                 3-Br-5-F-Phenyl 
               
               
                 8 
                 (CH 2 ) 5   
                 Me 
                 S 
                 3-Br-5-F-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 9 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 3-Br-5-F-Phenyl 
               
               
                 10 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 3-Br-5-F-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 11 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 3-Br-5-F-Phenyl 
               
               
                 12 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 3-Br-5-F-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 13 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 3-Br-5-F-Phenyl 
               
               
                 14 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 3-Br-5-F-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 15 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 3-Br-5-F-Phenyl 
               
               
                 16 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 3-Br-5-F-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 17 
                 Me 
                 Me 
                 Me 
                 O 
                 4-Br-3-iPr-Phenyl 
               
               
                 18 
                 Me 
                 Et 
                 Me 
                 O 
                 4-Br-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 19 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-Br-3-iPr-Phenyl 
               
               
                 20 
                 (CH 2 ) 5   
                 Me 
                 O 
                 4-Br-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 21 
                 Me 
                 Me 
                 Me 
                 S 
                 4-Br-3-iPr-Phenyl 
               
               
                 22 
                 Me 
                 Et 
                 Me 
                 S 
                 4-Br-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 23 
                 (CH 2 ) 4   
                 Me 
                 S 
                 4-Br-3-iPr-Phenyl 
               
               
                 24 
                 (CH 2 ) 5   
                 Me 
                 S 
                 4-Br-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 25 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 4-Br-3-iPr-Phenyl 
               
               
                 26 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 4-Br-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 27 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 4-Br-3-iPr-Phenyl 
               
               
                 28 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 4-Br-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 29 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 4-Br-3-iPr-Phenyl 
               
               
                 30 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 4-Br-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 31 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 4-Br-3-iPr-Phenyl 
               
               
                 32 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 4-Br-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 33 
                 Me 
                 Me 
                 Me 
                 O 
                 4-Cl-3-CF 3 -Phenyl 
               
               
                 34 
                 Me 
                 Et 
                 Me 
                 O 
                 4-Cl-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 35 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-Cl-3-CF 3 -Phenyl 
               
               
                 36 
                 (CH 2 ) 5   
                 Me 
                 O 
                 4-Cl-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 37 
                 Me 
                 Me 
                 Me 
                 S 
                 4-Cl-3-CF 3 -Phenyl 
               
               
                 38 
                 Me 
                 Et 
                 Me 
                 S 
                 4-Cl-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 39 
                 (CH 2 ) 4   
                 Me 
                 S 
                 4-Cl-3-CF 3 -Phenyl 
               
               
                 40 
                 (CH 2 ) 5   
                 Me 
                 S 
                 4-Cl-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 41 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-CF 3 -Phenyl 
               
               
                 42 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 43 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-CF 3 -Phenyl 
               
               
                 44 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 45 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-CF 3 -Phenyl 
               
               
                 46 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 47 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-CF 3 -Phenyl 
               
               
                 48 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 49 
                 Me 
                 Me 
                 Me 
                 O 
                 4-Cl-3-tBu-Phenyl 
               
               
                 50 
                 Me 
                 Et 
                 Me 
                 O 
                 4-Cl-3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 51 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-Cl-3-tBu-Phenyl 
               
               
                 52 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-Cl-3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 53 
                 Me 
                 Me 
                 Me 
                 S 
                 4-Cl-3-tBu-Phenyl 
               
               
                 54 
                 Me 
                 Et 
                 Me 
                 S 
                 4-Cl-3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 55 
                 (CH 2 ) 4   
                 Me 
                 S 
                 4-Cl-3-tBu-Phenyl 
               
               
                 56 
                 (CH 2 ) 5   
                 Me 
                 S 
                 4-Cl-3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 57 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-tBu-Phenyl 
               
               
                 58 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 59 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-tBu-Phenyl 
               
               
                 60 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 61 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-tBu-Phenyl 
               
               
                 62 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 63 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-tBu-Phenyl 
               
               
                 64 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 65 
                 Me 
                 Me 
                 Me 
                 O 
                 4-Cl-2-Me-Phenyl 
               
               
                 66 
                 Me 
                 Et 
                 Me 
                 O 
                 4-Cl-2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 67 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-Cl-2-Me-Phenyl 
               
               
                 68 
                 (CH 2 ) 5   
                 Me 
                 O 
                 4-Cl-2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 69 
                 Me 
                 Me 
                 Me 
                 S 
                 4-Cl-2-Me-Phenyl 
               
               
                 70 
                 Me 
                 Et 
                 Me 
                 S 
                 4-Cl-2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 71 
                 (CH 2 ) 4   
                 Me 
                 S 
                 4-Cl-2-Me-Phenyl 
               
               
                 72 
                 (CH 2 ) 5   
                 Me 
                 S 
                 4-Cl-2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 73 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 4-Cl-2-Me-Phenyl 
               
               
                 74 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 4-Cl-2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 75 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 4-Cl-2-Me-Phenyl 
               
               
                 76 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 4-Cl-2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 77 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-2-Me-Phenyl 
               
               
                 78 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 79 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-2-Me-Phenyl 
               
               
                 80 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 81 
                 Me 
                 Me 
                 Me 
                 O 
                 4-Cl-3-Me-Phenyl 
               
               
                 82 
                 Me 
                 Et 
                 Me 
                 O 
                 4-Cl-3-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 83 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-Cl-3-Me-Phenyl 
               
               
                 84 
                 (CH 2 ) 5   
                 Me 
                 O 
                 4-Cl-3-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 85 
                 Me 
                 Me 
                 Me 
                 S 
                 4-Cl-3-Me-Phenyl 
               
               
                 86 
                 Me 
                 Et 
                 Me 
                 S 
                 4-Cl-3-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 87 
                 (CH 2 ) 4   
                 Me 
                 S 
                 4-Cl-3-Me-Phenyl 
               
               
                 88 
                 (CH 2 ) 5   
                 Me 
                 S 
                 4-Cl-3-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 89 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-Me-Phenyl 
               
               
                 90 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 91 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-Me-Phenyl 
               
               
                 92 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 93 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-Me-Phenyl 
               
               
                 94 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 95 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-Me-Phenyl 
               
               
                 96 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 97 
                 Me 
                 Me 
                 Me 
                 O 
                 4-Cl-3-iPr-Phenyl 
               
               
                 98 
                 Me 
                 Et 
                 Me 
                 O 
                 4-Cl-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 99 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-Cl-3-iPr-Phenyl 
               
               
                 100 
                 (CH 2 ) 5   
                 Me 
                 O 
                 4-Cl-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 101 
                 Me 
                 Me 
                 Me 
                 S 
                 4-Cl-3-iPr-Phenyl 
               
               
                 102 
                 Me 
                 Et 
                 Me 
                 S 
                 4-Cl-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 103 
                 (CH 2 ) 4   
                 Me 
                 S 
                 4-Cl-3-iPr-Phenyl 
               
               
                 104 
                 (CH 2 ) 5   
                 Me 
                 S 
                 4-Cl-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 105 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-iPr-Phenyl 
               
               
                 106 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 107 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-iPr-Phenyl 
               
               
                 108 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 4-Cl-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 109 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-iPr-Phenyl 
               
               
                 110 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 111 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-iPr-Phenyl 
               
               
                 112 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 113 
                 Me 
                 Me 
                 Me 
                 O 
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 114 
                 Me 
                 Et 
                 Me 
                 O 
                 4-Cl-6-iPr-Pyridin-2-yl 
               
            
           
           
               
               
               
               
               
            
               
                 115 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 116 
                 (CH 2 ) 5   
                 Me 
                 O 
                 4-Cl-6-iPr-Pyridin-2-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 117 
                 Me 
                 Me 
                 Me 
                 S 
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 118 
                 Me 
                 Et 
                 Me 
                 S 
                 4-Cl-6-iPr-Pyridin-2-yl 
               
            
           
           
               
               
               
               
               
            
               
                 119 
                 (CH 2 ) 4   
                 Me 
                 S 
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 120 
                 (CH 2 ) 5   
                 Me 
                 S 
                 4-Cl-6-iPr-Pyridin-2-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 121 
                 Me 
                 Me 
                 Me 
                 OCH 2   
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 122 
                 Me 
                 Et 
                 Me 
                 OCH 2   
                 4-Cl-6-iPr-Pyridin-2-yl 
               
            
           
           
               
               
               
               
               
            
               
                 123 
                 (CH 2 ) 4   
                 Me 
                 OCH 2   
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 124 
                 (CH 2 ) 5   
                 Me 
                 OCH 2   
                 4-Cl-6-iPr-Pyridin-2-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 125 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 126 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-6-iPr-Pyridin-2-yl 
               
            
           
           
               
               
               
               
               
            
               
                 127 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 128 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 4-Cl-6-iPr-Pyridin-2-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 129 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
               
                 130 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 131 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
               
                 132 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 133 
                 Me 
                 Me 
                 Me 
                 S 
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
               
                 134 
                 Me 
                 Et 
                 Me 
                 S 
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 135 
                 (CH 2 ) 4   
                 Me 
                 S 
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
               
                 136 
                 (CH 2 ) 5   
                 Me 
                 S 
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 137 
                 Me 
                 Me 
                 Me 
                 OCH 2   
                 2-Cl-Pyridin-3-yl 
               
               
                 138 
                 Me 
                 Et 
                 Me 
                 OCH 2   
                 2-Cl-Pyridin-3-yl 
               
            
           
           
               
               
               
               
               
            
               
                 139 
                 (CH 2 ) 4   
                 Me 
                 OCH 2   
                 2-Cl-Pyridin-3-yl 
               
               
                 140 
                 (CH 2 ) 5   
                 Me 
                 OCH 2   
                 2-Cl-Pyridin-3-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 141 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 2-Cl-Pyridin-3-yl 
               
               
                 142 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 2-Cl-Pyridin-3-yl 
               
            
           
           
               
               
               
               
               
            
               
                 143 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 2-Cl-Pyridin-3-yl 
               
               
                 144 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 2-Cl-Pyridin-3-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 145 
                 Me 
                 Me 
                 Me 
                 O 
                 3-CF 3 -4-Me-Phenyl 
               
               
                 146 
                 Me 
                 Et 
                 Me 
                 O 
                 3-CF 3 -4-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 147 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-CF 3 -4-Me-Phenyl 
               
               
                 148 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-CF 3 -4-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 149 
                 Me 
                 Me 
                 Me 
                 S 
                 3-CF 3 -4-Me-Phenyl 
               
               
                 150 
                 Me 
                 Et 
                 Me 
                 S 
                 3-CF 3 -4-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 151 
                 (CH 2 ) 4   
                 Me 
                 S 
                 3-CF 3 -4-Me-Phenyl 
               
               
                 152 
                 (CH 2 ) 5   
                 Me 
                 S 
                 3-CF 3 -4-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 153 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 3-CF 3 -4-Me-Phenyl 
               
               
                 154 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 3-CF 3 -4-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 155 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 3-CF 3 -4-Me-Phenyl 
               
               
                 156 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 3-CF 3 -4-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 157 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 3-CF 3 -4-Me-Phenyl 
               
               
                 158 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 3-CF 3 -4-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 159 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 3-CF 3 -4-Me-Phenyl 
               
               
                 160 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 3-CF 3 -4-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 161 
                 Me 
                 Me 
                 Me 
                 O 
                 4-F-3-OCF 3 -Phenyl 
               
               
                 162 
                 Me 
                 Et 
                 Me 
                 O 
                 4-F-3-OCF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 163 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-F-3-OCF 3 -Phenyl 
               
               
                 164 
                 (CH 2 ) 5   
                 Me 
                 O 
                 4-F-3-OCF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 165 
                 Me 
                 Me 
                 Me 
                 S 
                 4-F-3-OCF 3 -Phenyl 
               
               
                 166 
                 Me 
                 Et 
                 Me 
                 S 
                 4-F-3-OCF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 167 
                 (CH 2 ) 4   
                 Me 
                 S 
                 4-F-3-OCF 3 -Phenyl 
               
               
                 168 
                 (CH 2 ) 5   
                 Me 
                 S 
                 4-F-3-OCF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 169 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 4-F-3-OCF 3 -Phenyl 
               
               
                 170 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 4-F-3-OCF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 171 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 4-F-3-OCF 3 -Phenyl 
               
               
                 172 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 4-F-3-OCF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 173 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 4-F-3-OCF 3 -Phenyl 
               
               
                 174 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 4-F-3-OCF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 175 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 4-F-3-OCF 3 -Phenyl 
               
               
                 176 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 4-F-3-OCF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 177 
                 Me 
                 Me 
                 Me 
                 O 
                 3-I-5-CF 3 -Phenyl 
               
               
                 178 
                 Me 
                 Et 
                 Me 
                 O 
                 3-I-5-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 179 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-I-5-CF 3 -Phenyl 
               
               
                 180 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-I-5-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 181 
                 Me 
                 Me 
                 Me 
                 S 
                 3-I-5-CF 3 -Phenyl 
               
               
                 182 
                 Me 
                 Et 
                 Me 
                 S 
                 3-I-5-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 183 
                 (CH 2 ) 4   
                 Me 
                 S 
                 3-I-5-CF 3 -Phenyl 
               
               
                 184 
                 (CH 2 ) 5   
                 Me 
                 S 
                 3-I-5-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 185 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 3-I-5-CF 3 -Phenyl 
               
               
                 186 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 3-I-5-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 187 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 3-I-5-CF 3 -Phenyl 
               
               
                 188 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 3-I-5-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 189 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 3-I-5-CF 3 -Phenyl 
               
               
                 190 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 3-I-5-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 191 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 3-I-5-CF 3 -Phenyl 
               
               
                 192 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 3-I-5-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 193 
                 Me 
                 Me 
                 Me 
                 O 
                 3-tBu-Phenyl 
               
               
                 194 
                 Me 
                 Et 
                 Me 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 195 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-tBu-Phenyl 
               
               
                 196 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 197 
                 Me 
                 Me 
                 Me 
                 S 
                 3-tBu-Phenyl 
               
               
                 198 
                 Me 
                 Et 
                 Me 
                 S 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 199 
                 (CH 2 ) 4   
                 Me 
                 S 
                 3-tBu-Phenyl 
               
               
                 200 
                 (CH 2 ) 5   
                 Me 
                 S 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 201 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 3-tBu-Phenyl 
               
               
                 202 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 203 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 3-tBu-Phenyl 
               
               
                 204 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 205 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 3-tBu-Phenyl 
               
               
                 206 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 207 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 3-tBu-Phenyl 
               
               
                 208 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 209 
                 Me 
                 Me 
                 Me 
                 O 
                 4-tBu-Phenyl 
               
               
                 210 
                 Me 
                 Et 
                 Me 
                 O 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 211 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-tBu-Phenyl 
               
               
                 212 
                 (CH 2 ) 5   
                 Me 
                 O 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 213 
                 Me 
                 Me 
                 Me 
                 S 
                 4-tBu-Phenyl 
               
               
                 214 
                 Me 
                 Et 
                 Me 
                 S 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 215 
                 (CH 2 ) 4   
                 Me 
                 S 
                 4-tBu-Phenyl 
               
               
                 216 
                 (CH 2 ) 5   
                 Me 
                 S 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 217 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 4-tBu-Phenyl 
               
               
                 218 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 219 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 4-tBu-Phenyl 
               
               
                 220 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 221 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 4-tBu-Phenyl 
               
               
                 222 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 223 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 4-tBu-Phenyl 
               
               
                 224 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 225 
                 Me 
                 Me 
                 Me 
                 O 
                 4-CN-3-CF 3 -Phenyl 
               
               
                 226 
                 Me 
                 Et 
                 Me 
                 O 
                 4-CN-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 227 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-CN-3-CF 3 -Phenyl 
               
               
                 228 
                 (CH 2 ) 5   
                 Me 
                 O 
                 4-CN-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 229 
                 Me 
                 Me 
                 Me 
                 S 
                 4-CN-3-CF 3 -Phenyl 
               
               
                 230 
                 Me 
                 Et 
                 Me 
                 S 
                 4-CN-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 231 
                 (CH 2 ) 4   
                 Me 
                 S 
                 4-CN-3-CF 3 -Phenyl 
               
               
                 232 
                 (CH 2 ) 5   
                 Me 
                 S 
                 4-CN-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 233 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 4-CN-3-CF 3 -Phenyl 
               
               
                 234 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 4-CN-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 235 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 4-CN-3-CF 3 -Phenyl 
               
               
                 236 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 4-CN-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 237 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 4-CN-3-CF 3 -Phenyl 
               
               
                 238 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 4-CN-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 239 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 4-CN-3-CF 3 -Phenyl 
               
               
                 240 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 4-CN-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 241 
                 Me 
                 Me 
                 Me 
                 O 
                 4-CF 3 -Phenyl 
               
               
                 242 
                 Me 
                 Et 
                 Me 
                 O 
                 4-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 243 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-CF 3 -Phenyl 
               
               
                 244 
                 (CH 2 ) 5   
                 Me 
                 O 
                 4-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 245 
                 Me 
                 Me 
                 Me 
                 S 
                 4-CF 3 -Phenyl 
               
               
                 246 
                 Me 
                 Et 
                 Me 
                 S 
                 4-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 247 
                 (CH 2 ) 4   
                 Me 
                 S 
                 4-CF 3 -Phenyl 
               
               
                 248 
                 (CH 2 ) 5   
                 Me 
                 S 
                 4-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 249 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 4-CF 3 -Phenyl 
               
               
                 250 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 4-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 251 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 4-CF 3 -Phenyl 
               
               
                 252 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 4-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 253 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 4-CF 3 -Phenyl 
               
               
                 254 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 4-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 255 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 4-CF 3 -Phenyl 
               
               
                 256 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 4-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 257 
                 Me 
                 Me 
                 Me 
                 O 
                 2-Me-Phenyl 
               
               
                 258 
                 Me 
                 Et 
                 Me 
                 O 
                 2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 259 
                 (CH 2 ) 4   
                 Me 
                 O 
                 2-Me-Phenyl 
               
               
                 260 
                 (CH 2 ) 5   
                 Me 
                 O 
                 2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 261 
                 Me 
                 Me 
                 Me 
                 S 
                 2-Me-Phenyl 
               
               
                 262 
                 Me 
                 Et 
                 Me 
                 S 
                 2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 263 
                 (CH 2 ) 4   
                 Me 
                 S 
                 2-Me-Phenyl 
               
               
                 264 
                 (CH 2 ) 5   
                 Me 
                 S 
                 2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 265 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 2-Me-Phenyl 
               
               
                 266 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 267 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 2-Me-Phenyl 
               
               
                 268 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 269 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 2-Me-Phenyl 
               
               
                 270 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 271 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 2-Me-Phenyl 
               
               
                 272 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 273 
                 Me 
                 Me 
                 Me 
                 O 
                 4-MeO-Phenyl 
               
               
                 274 
                 Me 
                 Et 
                 Me 
                 O 
                 4-MeO-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 275 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-MeO-Phenyl 
               
               
                 276 
                 (CH 2 ) 5   
                 Me 
                 O 
                 4-MeO-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 277 
                 Me 
                 Me 
                 Me 
                 S 
                 4-MeO-Phenyl 
               
               
                 278 
                 Me 
                 Et 
                 Me 
                 S 
                 4-MeO-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 279 
                 (CH 2 ) 4   
                 Me 
                 S 
                 4-MeO-Phenyl 
               
               
                 280 
                 (CH 2 ) 5   
                 Me 
                 S 
                 4-MeO-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 281 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 4-MeO-Phenyl 
               
               
                 282 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 4-MeO-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 283 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 4-MeO-Phenyl 
               
               
                 284 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 4-MeO-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 285 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 4-MeO-Phenyl 
               
               
                 286 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 4-MeO-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 287 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 4-MeO-Phenyl 
               
               
                 288 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 4-MeO-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 289 
                 Me 
                 Me 
                 Me 
                 O 
                 3-Ph-O-Phenyl 
               
               
                 290 
                 Me 
                 Et 
                 Me 
                 O 
                 3-Ph-O-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 291 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-Ph-O-Phenyl 
               
               
                 292 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-Ph-O-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 293 
                 Me 
                 Me 
                 Me 
                 S 
                 3-Ph-O-Phenyl 
               
               
                 294 
                 Me 
                 Et 
                 Me 
                 S 
                 3-Ph-O-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 295 
                 (CH 2 ) 4   
                 Me 
                 S 
                 3-Ph-O-Phenyl 
               
               
                 296 
                 (CH 2 ) 5   
                 Me 
                 S 
                 3-Ph-O-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 297 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 3-Ph-O-Phenyl 
               
               
                 298 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 3-Ph-O-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 299 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 3-Ph-O-Phenyl 
               
               
                 300 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 3-Ph-O-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 301 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 3-Ph-O-Phenyl 
               
               
                 302 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 3-Ph-O-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 303 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 3-Ph-O-Phenyl 
               
               
                 304 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 3-Ph-O-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 305 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(EtO-C(Me)Pr)-Phenyl 
               
               
                 306 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(EtO-C(Me)Pr)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 307 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(EtO-C(Me)Pr)-Phenyl 
               
               
                 308 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(EtO-C(Me)Pr)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 309 
                 Me 
                 Me 
                 Me 
                 S 
                 3-(EtO-C(Me)Pr)-Phenyl 
               
               
                 310 
                 Me 
                 Et 
                 Me 
                 S 
                 3-(EtO-C(Me)Pr)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 311 
                 (CH 2 ) 4   
                 Me 
                 S 
                 3-(EtO-C(Me)Pr)-Phenyl 
               
               
                 312 
                 (CH 2 ) 5   
                 Me 
                 S 
                 3-(EtO-C(Me)Pr)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 313 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 3-(EtO-C(Me)Pr)-Phenyl 
               
               
                 314 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 3-(EtO-C(Me)Pr)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 315 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 3-(EtO-C(Me)Pr)-Phenyl 
               
               
                 316 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 3-(EtO-C(Me)Pr)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 317 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 3-(EtO-C(Me)Pr)-Phenyl 
               
               
                 318 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 3-(EtO-C(Me)Pr)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 317 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 3-(EtO-C(Me)Pr)-Phenyl 
               
               
                 320 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 3-(EtO-C(Me)Pr)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 321 
                 Me 
                 iPr 
                 Me 
                 O 
                 3-Br-5-F-Phenyl 
               
               
                 322 
                 Me 
                 Me 
                 Me 
                 Bond 
                 3-Br-5-F-Phenyl 
               
               
                 323 
                 Me 
                 Et 
                 Me 
                 Bond 
                 3-Br-5-F-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 324 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 3-Br-5-F-Phenyl 
               
               
                 325 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 3-Br-5-F-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 326 
                 Me 
                 Me 
                 Me 
                 O 
                 3-Br-5-Cl-Phenyl 
               
               
                 327 
                 Me 
                 Et 
                 Me 
                 O 
                 3-Br-5-Cl-Phenyl 
               
               
                 328 
                 Me 
                 iPr 
                 Me 
                 O 
                 3-Br-5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 329 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-Br-5-Cl-Phenyl 
               
               
                 330 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-Br-5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 331 
                 Me 
                 Me 
                 Me 
                 S 
                 3-Br-5-Cl-Phenyl 
               
               
                 332 
                 Me 
                 Me 
                 Me 
                 Bond 
                 3-Br-5-Cl-Phenyl 
               
               
                 333 
                 Me 
                 Et 
                 Me 
                 Bond 
                 3-Br-5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 334 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 3-Br-5-Cl-Phenyl 
               
               
                 335 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 3-Br-5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 336 
                 Me 
                 Me 
                 Me 
                 O 
                 2-F-Phenyl 
               
               
                 337 
                 Me 
                 Et 
                 Me 
                 O 
                 2-F-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 338 
                 (CH 2 ) 4   
                 Me 
                 O 
                 2-F-Phenyl 
               
               
                 339 
                 (CH 2 ) 5   
                 Me 
                 O 
                 2-F-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 340 
                 Me 
                 Me 
                 Me 
                 S 
                 2-F-Phenyl 
               
               
                 341 
                 Me 
                 Et 
                 Me 
                 S 
                 2-F-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 342 
                 (CH 2 ) 4   
                 Me 
                 S 
                 2-F-Phenyl 
               
               
                 343 
                 (CH 2 ) 5   
                 Me 
                 S 
                 2-F-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 344 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 2-F-Phenyl 
               
               
                 345 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 2-F-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 346 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 2-F-Phenyl 
               
               
                 347 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 2-F-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 348 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 2-F-Phenyl 
               
               
                 349 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 2-F-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 350 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 2-F-Phenyl 
               
               
                 351 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 2-F-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 352 
                 Me 
                 Me 
                 Me 
                 Bond 
                 2-F-Phenyl 
               
               
                 353 
                 Me 
                 Et 
                 Me 
                 Bond 
                 2-F-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 354 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 2-F-Phenyl 
               
               
                 355 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 2-F-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 356 
                 Me 
                 Pr 
                 Me 
                 O 
                 4-Br-3-iPr-Phenyl 
               
               
                 357 
                 Me 
                 Me 
                 Me 
                 Bond 
                 4-Br-3-iPr-Phenyl 
               
               
                 358 
                 Me 
                 Et 
                 Me 
                 Bond 
                 4-Br-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 359 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 4-Br-3-iPr-Phenyl 
               
               
                 360 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 4-Br-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 361 
                 Me 
                 Me 
                 Me 
                 Bond 
                 4-Cl-3-CF 3 -Phenyl 
               
               
                 362 
                 Me 
                 Et 
                 Me 
                 Bond 
                 4-Cl-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 363 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 4-Cl-3-CF 3 -Phenyl 
               
               
                 364 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 4-Cl-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 365 
                 Me 
                 Me 
                 Me 
                 O 
                 4-F-3-CF 3 -Phenyl 
               
               
                 366 
                 Me 
                 Et 
                 Me 
                 O 
                 4-F-3-CF 3 -Phenyl 
               
               
                 367 
                 Me 
                 iPr 
                 Me 
                 O 
                 4-F-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 368 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-F-3-CF 3 -Phenyl 
               
               
                 369 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-F-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 370 
                 Me 
                 Me 
                 Me 
                 O 
                 5-F-3-CF 3 -Phenyl 
               
               
                 371 
                 Me 
                 Et 
                 Me 
                 O 
                 5-F-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 372 
                 (CH 2 ) 4   
                 Me 
                 O 
                 5-F-3-CF 3 -Phenyl 
               
               
                 373 
                 (CH 2 ) 5   
                 Me 
                 O 
                 5-F-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 374 
                 Me 
                 Me 
                 Me 
                 O 
                 4-Cl-3-CF 3 -Phenyl 
               
               
                 375 
                 Me 
                 Me 
                 Me 
                 Bond 
                 4-Cl-3-CF3-Phenyl 
               
               
                 376 
                 Me 
                 Et 
                 Me 
                 Bond 
                 4-Cl-3-CF3-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 377 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 4-Cl-3-CF 3 -Phenyl 
               
               
                 378 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 4-Cl-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 379 
                 Me 
                 Me 
                 Me 
                 O 
                 4-F-3-CF 3 -Phenyl 
               
               
                 380 
                 Me 
                 Et 
                 Me 
                 O 
                 4-F-3-CF 3 -Phenyl 
               
               
                 381 
                 Me 
                 iPr 
                 Me 
                 O 
                 4-F-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 382 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-F-3-CF 3 -Phenyl 
               
               
                 383 
                 (CH 2 ) 4   
                 Me 
                 O 
                 4-F-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 384 
                 Me 
                 Me 
                 Me 
                 O 
                 5-F-3-CF 3 -Phenyl 
               
               
                 385 
                 Me 
                 Et 
                 Me 
                 O 
                 5-F-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 386 
                 (CH 2 ) 4   
                 Me 
                 O 
                 5-F-3-CF 3 -Phenyl 
               
               
                 387 
                 (CH 2 ) 5   
                 Me 
                 O 
                 5-F-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 388 
                 Me 
                 Et 
                 Cl 
                 O 
                 4-Cl-3-tBu-Phenyl 
               
               
                 389 
                 Me 
                 Me 
                 Me 
                 Bond 
                 4-Cl-3-tBu-Phenyl 
               
               
                 390 
                 Me 
                 Et 
                 Me 
                 Bond 
                 4-Cl-3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 391 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 4-Cl-3-tBu-Phenyl 
               
               
                 392 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 4-Cl-3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 393 
                 Me 
                 Me 
                 Me 
                 Bond 
                 4-Cl-2-Me-Phenyl 
               
               
                 394 
                 Me 
                 Et 
                 Me 
                 Bond 
                 4-Cl-2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 395 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 4-Cl-2-Me-Phenyl 
               
               
                 396 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 4-Cl-2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 397 
                 Me 
                 Me 
                 Me 
                 Bond 
                 4-Cl-3-Me-Phenyl 
               
               
                 398 
                 Me 
                 Et 
                 Me 
                 Bond 
                 4-Cl-3-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 399 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 4-Cl-3-Me-Phenyl 
               
               
                 400 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 4-Cl-3-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 401 
                 Me 
                 iPr 
                 Me 
                 O 
                 4-Cl-3-iPr-Phenyl 
               
               
                 402 
                 Me 
                 cPr 
                 Cl 
                 O 
                 4-Cl-3-iPr-Phenyl 
               
               
                 403 
                 Me 
                 Me 
                 Me 
                 Bond 
                 4-Cl-3-iPr-Phenyl 
               
               
                 404 
                 Me 
                 Et 
                 Me 
                 Bond 
                 4-Cl-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 405 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 4-Cl-3-iPr-Phenyl 
               
               
                 406 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 4-Cl-3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 407 
                 Me 
                 Et 
                 Me 
                 O 
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 408 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 409 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 4-Cl-6-iPr-Pyridin-2-yl 
               
            
           
           
               
               
               
               
               
            
               
                 410 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 411 
                 (CH 2 ) 5   
                 Me 
                 CH 2 CH 2   
                 4-Cl-6-iPr-Pyridin-2-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 412 
                 Me 
                 Me 
                 Me 
                 Bond 
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 413 
                 Me 
                 Et 
                 Me 
                 Bond 
                 4-Cl-6-iPr-Pyridin-2-yl 
               
            
           
           
               
               
               
               
               
            
               
                 414 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 415 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 4-Cl-6-iPr-Pyridin-2-yl 
               
               
                 416 
                 (CH 2 ) 5   
                 Me 
                 S 
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 417 
                 Me 
                 Me 
                 Me 
                 CH 2 ═CH 2   
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
               
                 418 
                 Me 
                 Et 
                 Me 
                 CH 2 ═CH 2   
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 419 
                 (CH 2 ) 4   
                 Me 
                 CH 2 ═CH 2   
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
               
                 420 
                 (CH 2 ) 5   
                 Me 
                 CH 2 ═CH 2   
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 421 
                 Me 
                 Me 
                 Me 
                 CH 2 CH 2   
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
               
                 422 
                 Me 
                 Et 
                 Me 
                 CH 2 CH 2   
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 423 
                 (CH 2 ) 4   
                 Me 
                 CH 2 CH 2   
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
               
                 424 
                 (CH2)5 
                 Me 
                 CH 2 CH 2   
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 425 
                 Me 
                 Et 
                 Me 
                 Bond 
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 426 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
               
                 427 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 3-(2-Cl-Pyridin-3-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 428 
                 Me 
                 Me 
                 Me 
                 Bond 
                 3-CF 3 -4-Me-Phenyl 
               
               
                 429 
                 Me 
                 Et 
                 Me 
                 Bond 
                 3-CF 3 -4-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 430 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 3-CF 3 -4-Me-Phenyl 
               
               
                 431 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 3-CF 3 -4-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 432 
                 Me 
                 Me 
                 Me 
                 Bond 
                 4-F-3-OCF 3 -Phenyl 
               
               
                 433 
                 Me 
                 Et 
                 Me 
                 Bond 
                 4-F-3-OCF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 434 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 4-F-3-OCF 3 -Phenyl 
               
               
                 435 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 4-F-3-OCF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 436 
                 Me 
                 Me 
                 Me 
                 Bond 
                 3-I-5-CF 3 -Phenyl 
               
               
                 437 
                 Me 
                 Et 
                 Me 
                 Bond 
                 3-I-5-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 438 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 3-I-5-CF 3 -Phenyl 
               
               
                 439 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 3-I-5-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 440 
                 Me 
                 iPr 
                 Me 
                 O 
                 3-tBu-Phenyl 
               
               
                 441 
                 Me 
                 Me 
                 Me 
                 Bond 
                 3-tBu-Phenyl 
               
               
                 442 
                 Me 
                 Et 
                 Me 
                 Bond 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 443 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 3-tBu-Phenyl 
               
               
                 444 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 445 
                 Me 
                 Me 
                 Me 
                 Bond 
                 4-tBu-Phenyl 
               
               
                 446 
                 Me 
                 Et 
                 Me 
                 Bond 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 447 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 4-tBu-Phenyl 
               
               
                 448 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 449 
                 Me 
                 Me 
                 Me 
                 Bond 
                 4-CN-3-CF 3 -Phenyl 
               
               
                 450 
                 Me 
                 Et 
                 Me 
                 Bond 
                 4-CN-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 451 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 4-CN-3-CF 3 -Phenyl 
               
               
                 452 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 4-CN-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 453 
                 Me 
                 Me 
                 Me 
                 Bond 
                 4-CF 3 -Phenyl 
               
               
                 454 
                 Me 
                 Et 
                 Me 
                 Bond 
                 4-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 455 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 4-CF 3 -Phenyl 
               
               
                 456 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 4-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 457 
                 Me 
                 Me 
                 Me 
                 Bond 
                 2-Me-Phenyl 
               
               
                 458 
                 Me 
                 Et 
                 Me 
                 Bond 
                 2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 459 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 2-Me-Phenyl 
               
               
                 460 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 2-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 461 
                 Me 
                 Me 
                 Me 
                 Bond 
                 4-MeO-Phenyl 
               
               
                 462 
                 Me 
                 Et 
                 Me 
                 Bond 
                 4-MeO-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 463 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 4-MeO-Phenyl 
               
               
                 464 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 4-MeO-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 465 
                 Me 
                 Me 
                 Me 
                 Bond 
                 3-Ph-O-Phenyl 
               
               
                 466 
                 Me 
                 Et 
                 Me 
                 Bond 
                 3-Ph-O-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 467 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 3-Ph-O-Phenyl 
               
               
                 468 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 3-Ph-O-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 469 
                 Me 
                 Me 
                 Me 
                 Bond 
                 3-(EtO—C(Me)Pr)-Phenyl 
               
               
                 470 
                 Me 
                 Me 
                 Me 
                 Bond 
                 3-(EtO—C(Me)Pr)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 471 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 3-(EtO—C(Me)Pr)-Phenyl 
               
               
                 472 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 3-(EtO—C(Me)Pr)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 473 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(MeO—C(Me)Pr)-Phenyl 
               
               
                 474 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(MeO—C(Me)Pr)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 475 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(MeO—C(Me)Pr)-Phenyl 
               
               
                 476 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(MeO—C(Me)Pr)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 477 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(EtO—C(Me)(H 2 C═CH))-Phenyl 
               
               
                 478 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(EtO—C(Me)(H 2 C═CH))-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 479 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(EtO—C(Me)(H 2 C═CH))-Phenyl 
               
               
                 480 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(EtO—C(Me)(H 2 C═CH))-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 481 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(EtO—C(Me)(H 2 C═C(Me)CH 2 ))-Phenyl 
               
               
                 482 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(EtO—C(Me)(H 2 C═C(Me)CH 2 ))-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 483 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(EtO—C(Me)(H 2 C═C(Me)CH 2 ))-Phenyl 
               
               
                 484 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(EtO—C(Me)(H 2 C═C(Me)CH 2 ))-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 485 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(MeO—C(Me)(H 2 C═C(Me)CH 2 ))-Phenyl 
               
               
                 486 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(MeO—C(Me)(H 2 C═C(Me)CH 2 ))-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 487 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(MeO—C(Me)(H 2 C═C(Me)CH 2 ))-Phenyl 
               
               
                 488 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(MeO—C(Me)(H 2 C═C(Me)CH 2 ))-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 489 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(MeO—C(Me)(H 2 C═CHCH 2 ))-Phenyl 
               
               
                 490 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(MeO—C(Me)(H 2 C═CHCH 2 ))-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 491 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(MeO—C(Me)(H 2 C═CHCH 2 ))-Phenyl 
               
               
                 492 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(MeO—C(Me)(H 2 C═CHCH 2 ))-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 493 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(HO—C(Me)(H 2 C═CHCH 2 ))-Phenyl 
               
               
                 494 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(HO—C(Me)(H 2 C═CHCH 2 ))-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 495 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(HO—C(Me)(H 2 C═CHCH 2 ))-Phenyl 
               
               
                 496 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(HO—C(Me)(H 2 C═CHCH 2 ))-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 497 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(EtO—C(Me)(H 2 C═CHCH 2 ))-Phenyl 
               
               
                 498 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(EtO—C(Me)(H 2 C═CHCH 2 ))-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 499 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(EtO—C(Me)(H 2 C═CHCH 2 ))-Phenyl 
               
               
                 500 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(EtO—C(Me)(H 2 C═CHCH 2 ))-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 501 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(MeO—C(Me))Et-Phenyl 
               
               
                 502 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(MeO—C(Me))Et-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 503 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(MeO—C(Me))Et-Phenyl 
               
               
                 504 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(MeO—C(Me))Et-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 505 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(4,5-Dimethyl-1,3-dioxolan-2-yl)-Phenyl 
               
               
                 506 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(4,5-Dimethyl-1,3-dioxolan-2-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 507 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(4,5-Dimethyl-1,3-dioxolan-2-yl)-Phenyl 
               
               
                 508 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(4,5-Dimethyl-1,3-dioxolan-2-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 509 
                 Me 
                 Me 
                 Me 
                 Bond 
                 3-(4,5-Dimethyl-1,3-dioxolan-2-yl)-Phenyl 
               
               
                 510 
                 Me 
                 Et 
                 Me 
                 Bond 
                 3-(4,5-Dimethyl-1,3-dioxolan-2-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 511 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 3-(4,5-Dimethyl-1,3-dioxolan-2-yl)-Phenyl 
               
               
                 512 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 3-(4,5-Dimethyl-1,3-dioxolan-2-yl)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 513 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(tBu-carbonyl)-Phenyl 
               
               
                 514 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(tBu-carbonyl)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 515 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(tBu-carbonyl)-Phenyl 
               
               
                 516 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(tBu-carbonyl)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 517 
                 Me 
                 Me 
                 Me 
                 Bond 
                 3-(tBu-carbonyl)-Phenyl 
               
               
                 518 
                 Me 
                 Et 
                 Me 
                 Bond 
                 3-(tBu-carbonyl)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 519 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 3-(tBu-carbonyl)-Phenyl 
               
               
                 520 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 3-(tBu-carbonyl)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 521 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(tBu-O-carbonyl)-Phenyl 
               
               
                 522 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(tBu-O-carbonyl)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 523 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(tBu-O-carbonyl)-Phenyl 
               
               
                 524 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(tBu-O-carbonyl)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 525 
                 Me 
                 Me 
                 Me 
                 Bond 
                 3-(tBu-O-carbonyl)-Phenyl 
               
               
                 526 
                 Me 
                 Et 
                 Me 
                 Bond 
                 3-(tBu-O-carbonyl)-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 527 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 3-(tBu-O-carbonyl)-Phenyl 
               
               
                 528 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 3-(tBu-O-carbonyl)-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 529 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(HO—C(Me)(iPr))-Phenyl 
               
               
                 530 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(HO—C(Me)(iPr))-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 531 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(HO—C(Me)(iPr))-Phenyl 
               
               
                 532 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(HO—C(Me)(iPr))-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 533 
                 Me 
                 Me 
                 Me 
                 O 
                 3-(HO—C(Me)(tBu))-Phenyl 
               
               
                 534 
                 Me 
                 Et 
                 Me 
                 O 
                 3-(HO—C(Me)(tBu))-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 535 
                 (CH 2 ) 4   
                 Me 
                 O 
                 3-(HO—C(Me)(tBu))-Phenyl 
               
               
                 536 
                 (CH 2 ) 5   
                 Me 
                 O 
                 3-(HO—C(Me)(tBu))-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 537 
                 Me 
                 Me 
                 Me 
                 O 
                 2-Naphthyl 
               
               
                 538 
                 Me 
                 Et 
                 Me 
                 O 
                 2-Naphthyl 
               
               
                 539 
                 Me 
                 Et 
                 Me 
                 O 
                 2-Naphthyl 
               
            
           
           
               
               
               
               
               
            
               
                 540 
                 (CH 2 ) 4   
                 Me 
                 O 
                 2-Naphthyl 
               
               
                 541 
                 (CH 2 ) 5   
                 Me 
                 O 
                 2-Naphthyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 542 
                 Me 
                 Et 
                 Me 
                 Bond 
                 2-Naphthyl 
               
               
                 543 
                 Me 
                 Me 
                 Me 
                 Bond 
                 2-Naphthyl 
               
            
           
           
               
               
               
               
               
            
               
                 544 
                 (CH 2 ) 4   
                 Me 
                 Bond 
                 2-Naphthyl 
               
               
                 545 
                 (CH 2 ) 5   
                 Me 
                 Bond 
                 2-Naphthyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 546 
                 Me 
                 Me 
                 Me 
                 O 
                 (4-iPr)-thia-3,5-diazol-2-yl 
               
               
                 547 
                 Me 
                 Et 
                 Me 
                 O 
                 (4-iPr)-thia-3,5-diazol-2-yl 
               
            
           
           
               
               
               
               
               
            
               
                 548 
                 (CH 2 ) 4   
                 Me 
                 O 
                 (4-iPr)-thia-3,5-diazol-2-yl 
               
               
                 549 
                 (CH 2 ) 5   
                 Me 
                 O 
                 (4-iPr)-thia-3,5-diazol-2-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 550 
                 Me 
                 Me 
                 Me 
                 O 
                 2,4-Dichlorothiazol-5-yl 
               
               
                 551 
                 Me 
                 Et 
                 Me 
                 O 
                 2,4-Dichlorothiazol-5-yl 
               
            
           
           
               
               
               
               
               
            
               
                 552 
                 (CH 2 ) 4   
                 Me 
                 O 
                 2,4-Dichlorothiazol-5-yl 
               
               
                 553 
                 (CH 2 ) 5   
                 Me 
                 O 
                 2,4-Dichlorothiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 554 
                 Me 
                 Me 
                 Me 
                 OCH 2   
                 2,4-Dichlorothiazol-5-yl 
               
               
                 555 
                 Me 
                 Et 
                 Me 
                 OCH 2   
                 2,4-Dichlorothiazol-5-yl 
               
            
           
           
               
               
               
               
               
            
               
                 556 
                 (CH 2 ) 4   
                 Me 
                 OCH 2   
                 2,4-Dichlorothiazol-5-yl 
               
               
                 557 
                 (CH 2 ) 5   
                 Me 
                 OCH 2   
                 2,4-Dichlorothiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 558 
                 Me 
                 Me 
                 Me 
                 O 
                 5-Cl-4-tBu-thiazol-2-yl 
               
               
                 559 
                 Me 
                 Et 
                 Me 
                 O 
                 5-Cl-4-tBu-thiazol-2-yl 
               
               
                 560 
                 Me 
                 Me 
                 Cl 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 561 
                 Me 
                 Et 
                 Cl 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 562 
                 (CH 2 ) 4   
                 Cl 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 563 
                 (CH 2 ) 5   
                 Cl 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 564 
                 Me 
                 Me 
                 Cl 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 565 
                 Me 
                 Et 
                 Cl 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 566 
                 Me 
                 Pr 
                 Cl 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 567 
                 (CH 2 ) 4   
                 Cl 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 568 
                 (CH 2 ) 5   
                 Cl 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 569 
                 Me 
                 Me 
                 Cl 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
               
                 570 
                 Me 
                 Et 
                 Cl 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
               
                 571 
                 Me 
                 Pr 
                 Cl 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
               
                 572 
                 Me 
                 iPr 
                 Cl 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
               
                 573 
                 Me 
                 1-Methyl- 
                 Cl 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
               
                   
                   
                 propyl 
               
            
           
           
               
               
               
               
               
            
               
                 574 
                 (CH 2 ) 4   
                 Cl 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
               
                 575 
                 (CH 2 ) 5   
                 Cl 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 576 
                 Me 
                 Me 
                 Cl 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 577 
                 Me 
                 cPr 
                 Cl 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 578 
                 Me 
                 Pr 
                 Cl 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 579 
                 Me 
                 1-Methyl- 
                 Cl 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                   
                   
                 propyl 
               
            
           
           
               
               
               
               
               
            
               
                 580 
                 (CH 2 ) 4   
                 Cl 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 581 
                 (CH 2 ) 5   
                 Cl 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 582 
                 Me 
                 Me 
                 Cl 
                 O 
                 3-Et-4-Cl-Phenyl 
               
               
                 583 
                 Me 
                 Et 
                 Cl 
                 O 
                 3-Et-4-Cl-Phenyl 
               
               
                 584 
                 Me 
                 Pr 
                 Cl 
                 O 
                 3-Et-4-Cl-Phenyl 
               
               
                 585 
                 Me 
                 cPr 
                 Cl 
                 O 
                 3-Et-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 586 
                 (CH 2 ) 4   
                 Cl 
                 O 
                 3-Et-4-Cl-Phenyl 
               
               
                 587 
                 (CH 2 ) 5   
                 Cl 
                 O 
                 3-Et-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 588 
                 Me 
                 Me 
                 Cl 
                 O 
                 3-iPr-4-Br-Phenyl 
               
               
                 589 
                 Me 
                 Et 
                 Cl 
                 O 
                 3-iPr-4-Br-Phenyl 
               
               
                 590 
                 Me 
                 Pr 
                 Cl 
                 O 
                 3-iPr-4-Br-Phenyl 
               
               
                 591 
                 Me 
                 iPr 
                 Cl 
                 O 
                 3-iPr-4-Br-Phenyl 
               
               
                 592 
                 Me 
                 cPr 
                 Cl 
                 O 
                 3-iPr-4-Br-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 593 
                 (CH 2 ) 4   
                 Cl 
                 O 
                 3-iPr-4-Br-Phenyl 
               
               
                 594 
                 (CH 2 ) 5   
                 Cl 
                 O 
                 3-iPr-4-Br-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 595 
                 Me 
                 Me 
                 Cl 
                 O 
                 (1-Me-3-tBu)-1,2-pyrazol-5-yl 
               
               
                 596 
                 Me 
                 Et 
                 Cl 
                 O 
                 (1-Me-3-tBu)-1,2-pyrazol-5-yl 
               
               
                 597 
                 Me 
                 Pr 
                 Cl 
                 O 
                 (1-Me-3-tBu)-1,2-pyrazol-5-yl 
               
               
                 598 
                 Me 
                 cPr 
                 Cl 
                 O 
                 (1-Me-3-tBu)-1,2-pyrazol-5-yl 
               
            
           
           
               
               
               
               
               
            
               
                 599 
                 (CH 2 ) 4   
                 Cl 
                 O 
                 (1-Me-3-tBu)-1,2-pyrazol-5-yl 
               
               
                 600 
                 (CH 2 ) 5   
                 Cl 
                 O 
                 (1-Me-3-tBu)-1,2-pyrazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 601 
                 Me 
                 Me 
                 Cl 
                 O 
                 (1-Me-3-iPr)-1,2-pyrazol-5-yl 
               
               
                 602 
                 Me 
                 Et 
                 Cl 
                 O 
                 (1-Me-3-iPr)-1,2-pyrazol-5-yl 
               
               
                 603 
                 Me 
                 Pr 
                 Cl 
                 O 
                 (1-Me-3-iPr)-1,2-pyrazol-5-yl 
               
            
           
           
               
               
               
               
               
            
               
                 604 
                 (CH 2 ) 4   
                 Cl 
                 O 
                 (1-Me-3-iPr)-1,2-pyrazol-5-yl 
               
               
                 605 
                 (CH 2 ) 5   
                 Cl 
                 O 
                 (1-Me-3-iPr)-1,2-pyrazol-5-yl 
               
               
                 606 
                 2-MeCH(CH 2 ) 4 ) 
                 Cl 
                 O 
                 (1-Me-3-iPr)-1,2-pyrazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 607 
                 Me 
                 Me 
                 Cl 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
               
                 608 
                 Me 
                 Et 
                 Cl 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
            
               
                 609 
                 (CH 2 ) 4   
                 Cl 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
               
                 610 
                 (CH 2 ) 5   
                 Cl 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 611 
                 Me 
                 Me 
                 Cl 
                 O 
                 3-(1-Chlorocyclopropyl)-1,2,4- 
               
               
                   
                   
                   
                   
                   
                 thiadiazol-5-yl 
               
               
                 612 
                 Me 
                 Et 
                 Cl 
                 O 
                 3-(1-Chlorocyclopropyl)-1,2,4- 
               
               
                   
                   
                   
                   
                   
                 thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
            
               
                 613 
                 (CH 2 ) 4   
                 Cl 
                 O 
                 3-(1-Chlorocyclopropyl)-1,2,4- 
               
               
                   
                   
                   
                   
                 thiadiazol-5-yl 
               
               
                 614 
                 (CH 2 ) 5   
                 Cl 
                 O 
                 3-(1-Chlorocyclopropyl)-1,2,4- 
               
               
                   
                   
                   
                   
                 thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 615 
                 Me 
                 Me 
                 Cl 
                 O 
                 3-Phenyl-1,2,4-thiadiazol-5-yl 
               
               
                 616 
                 Me 
                 Et 
                 Cl 
                 O 
                 3-Phenyl-1,2,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
            
               
                 617 
                 (CH 2 ) 4   
                 Cl 
                 O 
                 3-Phenyl-1,2,4-thiadiazol-5-yl 
               
               
                 618 
                 (CH 2 ) 5   
                 Cl 
                 O 
                 3-Phenyl-1,2,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 619 
                 Me 
                 Me 
                 Cl 
                 O 
                 4-(4-Chlorophenoxy)-5-fluoropyrimidin- 
               
               
                   
                   
                   
                   
                   
                 6-yl 
               
               
                 620 
                 Me 
                 Et 
                 Cl 
                 O 
                 4-(4-Chlorophenoxy)-5-fluoropyrimidin- 
               
               
                   
                   
                   
                   
                   
                 6-yl 
               
            
           
           
               
               
               
               
               
            
               
                 621 
                 (CH 2 ) 4   
                 Cl 
                 O 
                 4-(4-Chlorophenoxy)-5-fluoropyrimidin- 
               
               
                   
                   
                   
                   
                 6-yl 
               
               
                 622 
                 (CH 2 ) 5   
                 Cl 
                 O 
                 4-(4-Chlorophenoxy)-5-fluoropyrimidin- 
               
               
                   
                   
                   
                   
                 6-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 623 
                 Me 
                 Me 
                 Cl 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 624 
                 Me 
                 Et 
                 Cl 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 625 
                 (CH 2 ) 4   
                 Cl 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 626 
                 (CH 2 ) 5   
                 Cl 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 627 
                 Me 
                 Me 
                 Cl 
                 Bond 
                 3-iPr-4-Cl-Phenyl 
               
               
                 628 
                 Me 
                 Et 
                 Cl 
                 Bond 
                 3-iPr-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 629 
                 (CH 2 ) 4   
                 Cl 
                 Bond 
                 3-iPr-4-Cl-Phenyl 
               
               
                 630 
                 (CH 2 ) 5   
                 Cl 
                 Bond 
                 3-iPr-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 631 
                 Me 
                 Me 
                 Cl 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 632 
                 Me 
                 Et 
                 Cl 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 633 
                 (CH 2 ) 4   
                 Cl 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 634 
                 (CH 2 ) 5   
                 Cl 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 635 
                 Me 
                 Me 
                 F 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 636 
                 Me 
                 Et 
                 F 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 637 
                 (CH 2 ) 4   
                 F 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 638 
                 (CH 2 ) 5   
                 F 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 639 
                 Me 
                 Me 
                 F 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 640 
                 Me 
                 Et 
                 F 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 641 
                 (CH 2 ) 4   
                 F 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 642 
                 (CH 2 ) 5   
                 F 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 643 
                 Me 
                 Me 
                 F 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 644 
                 Me 
                 Et 
                 F 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 645 
                 (CH 2 ) 4   
                 F 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 646 
                 (CH 2 ) 5   
                 F 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 647 
                 Me 
                 Me 
                 F 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
               
                 648 
                 Me 
                 Et 
                 F 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
            
               
                 649 
                 (CH 2 ) 4   
                 F 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
               
                 650 
                 (CH 2 ) 5   
                 F 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 651 
                 Me 
                 Me 
                 F 
                 O 
                 3-Phenyl-1,2,4-thiadiazol-5-yl 
               
               
                 652 
                 Me 
                 Et 
                 F 
                 O 
                 3-Phenyl-1,2,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
            
               
                 653 
                 (CH 2 ) 4   
                 F 
                 O 
                 3-Phenyl-1,2,4-thiadiazol-5-yl 
               
               
                 654 
                 (CH 2 ) 5   
                 F 
                 O 
                 3-Phenyl-1,2,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 655 
                 Me 
                 Me 
                 F 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 656 
                 Me 
                 Et 
                 F 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 657 
                 (CH 2 ) 4   
                 F 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 658 
                 (CH 2 ) 5   
                 F 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 659 
                 Me 
                 Me 
                 F 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 660 
                 Me 
                 Et 
                 F 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 661 
                 (CH 2 ) 4   
                 F 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 662 
                 (CH 2 ) 5   
                 F 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 663 
                 Me 
                 Me 
                 F 
                 Bond 
                 4-Chlorophenyl 
               
               
                 664 
                 Me 
                 Et 
                 F 
                 Bond 
                 4-Chlorophenyl 
               
               
                 665 
                 Me 
                 iPr 
                 F 
                 Bond 
                 4-Chlorophenyl 
               
            
           
           
               
               
               
               
               
            
               
                 666 
                 (CH 2 ) 4   
                 F 
                 Bond 
                 4-Chlorophenyl 
               
               
                 667 
                 (CH 2 ) 5   
                 F 
                 Bond 
                 4-Chlorophenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 668 
                 Me 
                 Me 
                 F 
                 Bond 
                 4-tBuphenyl 
               
               
                 669 
                 Me 
                 Et 
                 F 
                 Bond 
                 4-tBuphenyl 
               
            
           
           
               
               
               
               
               
            
               
                 670 
                 (CH 2 ) 4   
                 F 
                 Bond 
                 4-tBuphenyl 
               
               
                 671 
                 (CH 2 ) 5   
                 F 
                 Bond 
                 4-tBuphenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 672 
                 Me 
                 Me 
                 F 
                 Bond 
                 4-tButoxyphenyl 
               
               
                 673 
                 Me 
                 Et 
                 F 
                 Bond 
                 4-tButoxyphenyl 
               
            
           
           
               
               
               
               
               
            
               
                 674 
                 (CH 2 ) 4   
                 F 
                 Bond 
                 4-tButoxyphenyl 
               
               
                 675 
                 (CH 2 ) 5   
                 F 
                 Bond 
                 4-tButoxyphenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 676 
                 Me 
                 Me 
                 F 
                 Bond 
                 3-tBuphenyl 
               
               
                 677 
                 Me 
                 Et 
                 F 
                 Bond 
                 3-tBuphenyl 
               
            
           
           
               
               
               
               
               
            
               
                 678 
                 (CH 2 ) 4   
                 F 
                 Bond 
                 3-tBuphenyl 
               
               
                 679 
                 (CH 2 ) 5   
                 F 
                 Bond 
                 3-tBuphenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 680 
                 Me 
                 Me 
                 F 
                 Bond 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
               
                 681 
                 Me 
                 Et 
                 F 
                 Bond 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
            
               
                 682 
                 (CH 2 ) 4   
                 F 
                 Bond 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
               
                 683 
                 (CH 2 ) 5   
                 F 
                 Bond 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 684 
                 Me 
                 Me 
                 Br 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 685 
                 Me 
                 Et 
                 Br 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 686 
                 (CH 2 ) 4   
                 Br 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 687 
                 (CH 2 ) 5   
                 Br 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 688 
                 Me 
                 Me 
                 Br 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 689 
                 Me 
                 Et 
                 Br 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 690 
                 (CH 2 ) 4   
                 Br 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 691 
                 (CH 2 ) 5   
                 Br 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 692 
                 Me 
                 Me 
                 Br 
                 O 
                 3-tBu-Phenyl 
               
               
                 693 
                 Me 
                 Et 
                 Br 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 694 
                 (CH 2 ) 4   
                 Br 
                 O 
                 3-tBu-Phenyl 
               
               
                 695 
                 (CH 2 ) 5   
                 Br 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 696 
                 Me 
                 Me 
                 Br 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 697 
                 Me 
                 Et 
                 Br 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 698 
                 (CH 2 ) 4   
                 Br 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 699 
                 (CH 2 ) 5   
                 Br 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 700 
                 Me 
                 Me 
                 Br 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
               
                 701 
                 Me 
                 Et 
                 Br 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 702 
                 (CH 2 ) 4   
                 Br 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
               
                 703 
                 (CH 2 ) 5   
                 Br 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 704 
                 Me 
                 Me 
                 Br 
                 O 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
               
                 705 
                 Me 
                 Et 
                 Br 
                 O 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
            
               
                 706 
                 (CH 2 ) 4   
                 Br 
                 O 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
               
                 707 
                 (CH 2 ) 5   
                 Br 
                 O 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 708 
                 Me 
                 Me 
                 Br 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 709 
                 Me 
                 Et 
                 Br 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 710 
                 (CH 2 ) 4   
                 Br 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 711 
                 (CH 2 ) 5   
                 Br 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 712 
                 Me 
                 Me 
                 Br 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 713 
                 Me 
                 Et 
                 Br 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 714 
                 (CH 2 ) 4   
                 Br 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 715 
                 (CH 2 ) 5   
                 Br 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 716 
                 Me 
                 Me 
                 Br 
                 Bond 
                 3-tBu-Phenyl 
               
               
                 717 
                 Me 
                 Et 
                 Br 
                 Bond 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 718 
                 (CH 2 ) 4   
                 Br 
                 Bond 
                 3-tBu-Phenyl 
               
               
                 719 
                 (CH 2 ) 5   
                 Br 
                 Bond 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 720 
                 Me 
                 Me 
                 OMe 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 721 
                 Me 
                 Et 
                 OMe 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 722 
                 (CH 2 ) 4   
                 OMe 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 723 
                 (CH 2 ) 5   
                 OMe 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 724 
                 Me 
                 Me 
                 OMe 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 725 
                 Me 
                 Et 
                 OMe 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 726 
                 (CH 2 ) 4   
                 OMe 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 727 
                 (CH 2 ) 5   
                 OMe 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 728 
                 Me 
                 Me 
                 OMe 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
               
                 729 
                 Me 
                 Et 
                 OMe 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 730 
                 (CH 2 ) 4   
                 OMe 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
               
                 731 
                 (CH 2 ) 5   
                 OMe 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 732 
                 Me 
                 Me 
                 OMe 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 733 
                 Me 
                 Et 
                 OMe 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 734 
                 (CH 2 ) 4   
                 OMe 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 735 
                 (CH 2 ) 5   
                 OMe 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 736 
                 Me 
                 Me 
                 OMe 
                 O 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
               
                 737 
                 Me 
                 Et 
                 OMe 
                 O 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
            
               
                 738 
                 (CH 2 ) 4   
                 OMe 
                 O 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
               
                 739 
                 (CH 2 ) 5   
                 OMe 
                 O 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 740 
                 Me 
                 Me 
                 OMe 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 741 
                 Me 
                 Et 
                 OMe 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 742 
                 (CH 2 ) 4   
                 OMe 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 743 
                 (CH 2 ) 5   
                 OMe 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 744 
                 Me 
                 Me 
                 OMe 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 745 
                 Me 
                 Et 
                 OMe 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 746 
                 (CH 2 ) 4   
                 OMe 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 747 
                 (CH 2 ) 5   
                 OMe 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 748 
                 Me 
                 Me 
                 OMe 
                 Bond 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
               
                 749 
                 Me 
                 Et 
                 OMe 
                 Bond 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
            
               
                 750 
                 (CH 2 ) 4   
                 OMe 
                 Bond 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
               
                 751 
                 (CH 2 ) 5   
                 OMe 
                 Bond 
                 2-(Cyclopropyl)-1,3,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 752 
                 Me 
                 Me 
                 CF 3   
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 753 
                 Me 
                 Et 
                 CF 3   
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 754 
                 (CH 2 ) 4   
                 CF 3   
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 755 
                 (CH 2 ) 5   
                 CF 3   
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 756 
                 Me 
                 Me 
                 CF 3   
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 757 
                 Me 
                 Et 
                 CF 3   
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 758 
                 (CH 2 ) 4   
                 CF 3   
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 759 
                 (CH 2 ) 5   
                 CF 3   
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 760 
                 Me 
                 Me 
                 CF 3   
                 O 
                 3-tBu-Phenyl 
               
               
                 761 
                 Me 
                 Et 
                 CF 3   
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 762 
                 (CH 2 ) 4   
                 CF 3   
                 O 
                 3-tBu-Phenyl 
               
               
                 763 
                 (CH 2 ) 5   
                 CF 3   
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 764 
                 Me 
                 Me 
                 CF 3   
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 765 
                 Me 
                 Et 
                 CF 3   
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 766 
                 (CH 2 ) 4   
                 CF 3   
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 767 
                 (CH 2 ) 5   
                 CF 3   
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 768 
                 Me 
                 Me 
                 CF 3   
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 769 
                 Me 
                 Et 
                 CF 3   
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 770 
                 (CH 2 ) 4   
                 CF 3   
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 771 
                 (CH 2 ) 5   
                 CF 3   
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 772 
                 Me 
                 Me 
                 CF 3   
                 Bond 
                 4-tBu-Phenyl 
               
               
                 773 
                 Me 
                 Et 
                 CF 3   
                 Bond 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 774 
                 (CH 2 ) 4   
                 CF 3   
                 Bond 
                 4-tBu-Phenyl 
               
               
                 775 
                 (CH 2 ) 5   
                 CF 3   
                 Bond 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 776 
                 Me 
                 Me 
                 CF 2 H 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 777 
                 Me 
                 Et 
                 CF 2 H 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 778 
                 (CH 2 ) 4   
                 CF 2 H 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 779 
                 (CH 2 ) 5   
                 CF 2 H 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 780 
                 Me 
                 Me 
                 CF 2 H 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 781 
                 Me 
                 Et 
                 CF 2 H 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 782 
                 (CH 2 ) 4   
                 CF 2 H 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 783 
                 (CH 2 ) 5   
                 CF 2 H 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 784 
                 Me 
                 Me 
                 CF 2 H 
                 O 
                 3-iPr-Phenyl 
               
               
                 785 
                 Me 
                 Et 
                 CF 2 H 
                 O 
                 3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 786 
                 (CH 2 ) 4   
                 CF 2 H 
                 O 
                 3-iPr-Phenyl 
               
               
                 787 
                 (CH 2 ) 5   
                 CF 2 H 
                 O 
                 3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 788 
                 Me 
                 Me 
                 CF 2 H 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 789 
                 Me 
                 Et 
                 CF 2 H 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 790 
                 (CH 2 ) 4   
                 CF 2 H 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 791 
                 (CH 2 ) 5   
                 CF 2 H 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 792 
                 Me 
                 Me 
                 CF 2 H 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 793 
                 Me 
                 Et 
                 CF 2 H 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 794 
                 (CH 2 ) 4   
                 CF 2 H 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 795 
                 (CH 2 ) 5   
                 CF 2 H 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 796 
                 Me 
                 Me 
                 CF 2 H 
                 Bond 
                 3-iPr-Phenyl 
               
               
                 797 
                 Me 
                 Et 
                 CF 2 H 
                 Bond 
                 3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
            
               
                 798 
                 (CH 2 ) 4   
                 CF 2 H 
                 Bond 
                 3-iPr-Phenyl 
               
               
                 799 
                 (CH 2 ) 5   
                 CF 2 H 
                 Bond 
                 3-iPr-Phenyl 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Compounds according to the invention of formula (I) (in table 2, R 4  is not methyl) 
               
            
           
           
               
               
            
               
                   
                 (I) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 No. 
                 R 2   
                 R 3   
                 R 4   
                 R 5   
                 A 
                 R 6   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 800 
                 Me 
                 Me 
                 Cl 
                 Cl 
                 O 
                 Phenyl 
               
               
                 801 
                 Me 
                 Et 
                 Cl 
                 Cl 
                 O 
                 Phenyl 
               
               
                 802 
                 Me 
                 iPr 
                 Cl 
                 Cl 
                 O 
                 Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 803 
                 (CH 2 ) 4   
                 Cl 
                 Cl 
                 O 
                 Phenyl 
               
               
                 804 
                 (CH 2 ) 5   
                 Cl 
                 Cl 
                 O 
                 Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 805 
                 Me 
                 Me 
                 Cl 
                 Cl 
                 O 
                 3-tBu-Phenyl 
               
               
                 806 
                 Me 
                 Et 
                 Cl 
                 Cl 
                 O 
                 3-tBu-Phenyl 
               
               
                 807 
                 Me 
                 iPr 
                 Cl 
                 Cl 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 808 
                 (CH 2 ) 4   
                 Cl 
                 Cl 
                 O 
                 3-tBu-Phenyl 
               
               
                 809 
                 (CH 2 ) 5   
                 Cl 
                 Cl 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 810 
                 Me 
                 Me 
                 Cl 
                 Cl 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 811 
                 Me 
                 Et 
                 Cl 
                 Cl 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 812 
                 Me 
                 iPr 
                 Cl 
                 Cl 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 813 
                 (CH 2 ) 4   
                 Cl 
                 Cl 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 814 
                 (CH 2 ) 5   
                 Cl 
                 Cl 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 815 
                 Me 
                 Me 
                 Cl 
                 Cl 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 816 
                 Me 
                 Et 
                 Cl 
                 Cl 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 817 
                 Me 
                 iPr 
                 Cl 
                 Cl 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 818 
                 (CH 2 ) 4   
                 Cl 
                 Cl 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 819 
                 (CH 2 ) 5   
                 Cl 
                 Cl 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 820 
                 Me 
                 Me 
                 Cl 
                 Cl 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 821 
                 Me 
                 Et 
                 Cl 
                 Cl 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 822 
                 (CH 2 ) 4   
                 Cl 
                 Cl 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 823 
                 (CH 2 ) 5   
                 Cl 
                 Cl 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 824 
                 Me 
                 Me 
                 Cl 
                 Cl 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
               
                 825 
                 Me 
                 Et 
                 Cl 
                 Cl 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
               
                 826 
                 Me 
                 iPr 
                 Cl 
                 Cl 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 827 
                 (CH 2 ) 4   
                 Cl 
                 Cl 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
               
                 828 
                 (CH 2 ) 5   
                 Cl 
                 Cl 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 829 
                 Me 
                 Me 
                 F 
                 F 
                 O 
                 3-tBu-Phenyl 
               
               
                 830 
                 Me 
                 Et 
                 F 
                 F 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 831 
                 (CH 2 ) 4   
                 F 
                 F 
                 O 
                 3-tBu-Phenyl 
               
               
                 832 
                 (CH 2 ) 5   
                 F 
                 F 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 833 
                 Me 
                 Me 
                 F 
                 F 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 834 
                 Me 
                 Et 
                 F 
                 F 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 835 
                 (CH 2 ) 4   
                 F 
                 F 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 836 
                 (CH 2 ) 5   
                 F 
                 F 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 837 
                 Me 
                 Me 
                 F 
                 F 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 838 
                 Me 
                 Et 
                 F 
                 F 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 839 
                 (CH 2 ) 4   
                 F 
                 F 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 840 
                 (CH 2 ) 5   
                 F 
                 F 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 841 
                 Me 
                 Me 
                 F 
                 F 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 842 
                 Me 
                 Et 
                 F 
                 F 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 843 
                 (CH 2 ) 4   
                 F 
                 F 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 844 
                 (CH 2 ) 5   
                 F 
                 F 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 845 
                 Me 
                 Me 
                 F 
                 F 
                 Bond 
                 4-tBu-Phenyl 
               
               
                 846 
                 Me 
                 Et 
                 F 
                 F 
                 Bond 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 847 
                 (CH 2 ) 4   
                 F 
                 F 
                 Bond 
                 4-tBu-Phenyl 
               
               
                 848 
                 (CH 2 ) 5   
                 F 
                 F 
                 Bond 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 849 
                 Me 
                 Me 
                 F 
                 F 
                 Bond 
                 3-tBu-4-Cl-Phenyl 
               
               
                 850 
                 Me 
                 Et 
                 F 
                 F 
                 Bond 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 851 
                 (CH 2 ) 4   
                 F 
                 F 
                 Bond 
                 3-tBu-4-Cl-Phenyl 
               
               
                 852 
                 (CH 2 ) 5   
                 F 
                 F 
                 Bond 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 853 
                 Me 
                 Me 
                 F 
                 F 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 854 
                 Me 
                 Et 
                 F 
                 F 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 855 
                 (CH 2 ) 4   
                 F 
                 F 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 856 
                 (CH 2 ) 5   
                 F 
                 F 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 857 
                 Me 
                 Me 
                 F 
                 F 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 858 
                 Me 
                 Et 
                 F 
                 F 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 859 
                 (CH 2 ) 4   
                 F 
                 F 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 860 
                 (CH 2 ) 5   
                 F 
                 F 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 861 
                 Me 
                 Me 
                 I 
                 Cl 
                 O 
                 3-tBu-Phenyl 
               
               
                 862 
                 Me 
                 Et 
                 I 
                 Cl 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 863 
                 (CH 2 ) 4   
                 I 
                 Cl 
                 O 
                 3-tBu-Phenyl 
               
               
                 864 
                 (CH 2 ) 5   
                 I 
                 Cl 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 865 
                 Me 
                 Me 
                 I 
                 Cl 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 866 
                 Me 
                 Et 
                 I 
                 Cl 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 867 
                 (CH 2 ) 4   
                 I 
                 Cl 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 868 
                 (CH 2 ) 5   
                 I 
                 Cl 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 869 
                 Me 
                 Me 
                 Cl 
                 Me 
                 O 
                 3-tBu-Phenyl 
               
               
                 870 
                 Me 
                 Et 
                 Cl 
                 Me 
                 O 
                 3-tBu-Phenyl 
               
               
                 871 
                 Me 
                 iPr 
                 Cl 
                 Me 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 872 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 O 
                 3-tBu-Phenyl 
               
               
                 873 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 874 
                 Me 
                 Me 
                 Cl 
                 Me 
                 O 
                 3-iPr-Phenyl 
               
               
                 875 
                 Me 
                 Et 
                 Cl 
                 Me 
                 O 
                 3-iPr-Phenyl 
               
               
                 876 
                 Me 
                 iPr 
                 Cl 
                 Me 
                 O 
                 3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 877 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 O 
                 3-iPr-Phenyl 
               
               
                 878 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 O 
                 3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 879 
                 Me 
                 Me 
                 Cl 
                 Me 
                 O 
                 3-OPh 
               
               
                 880 
                 Me 
                 Et 
                 Cl 
                 Me 
                 O 
                 3-OPh 
               
            
           
           
               
               
               
               
               
               
            
               
                 881 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 O 
                 3-OPh 
               
               
                 882 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 O 
                 3-OPh 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 883 
                 Me 
                 Me 
                 Cl 
                 Me 
                 O 
                 4-tBu-Phenyl 
               
               
                 884 
                 Me 
                 Et 
                 Cl 
                 Me 
                 O 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 885 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 O 
                 4-tBu-Phenyl 
               
               
                 886 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 O 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 887 
                 Me 
                 Me 
                 Cl 
                 Me 
                 O 
                 4-iPr-Phenyl 
               
               
                 888 
                 Me 
                 Et 
                 Cl 
                 Me 
                 O 
                 4-iPr-Phenyl 
               
               
                 889 
                 Me 
                 iPr 
                 Cl 
                 Me 
                 O 
                 4-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 890 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 O 
                 4-iPr-Phenyl 
               
               
                 891 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 O 
                 4-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 892 
                 Me 
                 Me 
                 Cl 
                 Me 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 893 
                 Me 
                 Et 
                 Cl 
                 Me 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 894 
                 Me 
                 iPr 
                 Cl 
                 Me 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 895 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 896 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 897 
                 Me 
                 Me 
                 Cl 
                 Me 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
               
                 898 
                 Me 
                 Et 
                 Cl 
                 Me 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
               
                 899 
                 Me 
                 iPr 
                 Cl 
                 Me 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 900 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
               
                 901 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 O 
                 3-iPr-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 902 
                 Me 
                 Me 
                 Cl 
                 Me 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 903 
                 Me 
                 Et 
                 Cl 
                 Me 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 904 
                 Me 
                 iPr 
                 Cl 
                 Me 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 905 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 906 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 907 
                 Me 
                 Me 
                 Cl 
                 Me 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 908 
                 Me 
                 Et 
                 Cl 
                 Me 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 909 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 910 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 911 
                 Me 
                 Me 
                 Cl 
                 Me 
                 O 
                 (4-(4-Chlorophenyl)-5-fluoropyrimidin-5-yl) 
               
               
                 912 
                 Me 
                 Et 
                 Cl 
                 Me 
                 O 
                 (4-(4-Chlorophenyl)-5-fluoropyrimidin-5-yl) 
               
            
           
           
               
               
               
               
               
               
            
               
                 913 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 O 
                 (4-(4-Chlorophenyl)-5-fluoropyrimidin-5-yl) 
               
               
                 914 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 O 
                 (4-(4-Chlorophenyl)-5-fluoropyrimidin-5-yl) 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 915 
                 Me 
                 Me 
                 Cl 
                 Me 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
               
                 916 
                 Me 
                 Et 
                 Cl 
                 Me 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
            
               
                 917 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
               
                 918 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 O 
                 (3-tBu)-1,2,4-thiadiazol-5-yl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 919 
                 Me 
                 Me 
                 Cl 
                 Me 
                 Bond 
                 3-iPr-Phenyl 
               
               
                 920 
                 Me 
                 Et 
                 Cl 
                 Me 
                 Bond 
                 3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 921 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 Bond 
                 3-iPr-Phenyl 
               
               
                 922 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 Bond 
                 3-iPr-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 923 
                 Me 
                 Me 
                 Cl 
                 Me 
                 Bond 
                 3-tBu-4-Cl-Phenyl 
               
               
                 924 
                 Me 
                 Et 
                 Cl 
                 Me 
                 Bond 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 925 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 Bond 
                 3-tBu-4-Cl-Phenyl 
               
               
                 926 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 Bond 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 927 
                 Me 
                 Me 
                 Cl 
                 Me 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 928 
                 Me 
                 Et 
                 Cl 
                 Me 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 929 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 930 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 931 
                 Me 
                 Me 
                 Cl 
                 Me 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 932 
                 Me 
                 Et 
                 Cl 
                 Me 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 933 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 934 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 Bond 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 935 
                 Me 
                 Me 
                 Cl 
                 Me 
                 Bond 
                 4-tBu-Phenyl 
               
               
                 936 
                 Me 
                 Et 
                 Cl 
                 Me 
                 Bond 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 937 
                 (CH 2 ) 4   
                 Cl 
                 Me 
                 Bond 
                 4-tBu-Phenyl 
               
               
                 938 
                 (CH 2 ) 5   
                 Cl 
                 Me 
                 Bond 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 939 
                 Me 
                 Me 
                 Cl 
                 CF 3   
                 O 
                 3-tBu-Phenyl 
               
               
                 940 
                 Me 
                 Et 
                 Cl 
                 CF 3   
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 941 
                 (CH 2 ) 4   
                 Cl 
                 CF 3   
                 O 
                 3-tBu-Phenyl 
               
               
                 942 
                 (CH 2 ) 5   
                 Cl 
                 CF 3   
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 943 
                 Me 
                 Me 
                 Cl 
                 CF 3   
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 944 
                 Me 
                 Et 
                 Cl 
                 CF 3   
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 945 
                 (CH 2 ) 4   
                 Cl 
                 CF 3   
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 946 
                 (CH 2 ) 5   
                 Cl 
                 CF 3   
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 947 
                 Me 
                 Me 
                 Cl 
                 CF 3   
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 948 
                 Me 
                 Et 
                 Cl 
                 CF 3   
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 949 
                 Me 
                 iPr 
                 Cl 
                 CF 3   
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 950 
                 (CH 2 ) 4   
                 Cl 
                 CF 3   
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 951 
                 (CH 2 ) 5   
                 Cl 
                 CF 3   
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 952 
                 Me 
                 Me 
                 Cl 
                 CF 3   
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 953 
                 Me 
                 Et 
                 Cl 
                 CF 3   
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 954 
                 (CH 2 ) 4   
                 Cl 
                 CF 3   
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 955 
                 (CH 2 ) 5   
                 Cl 
                 CF 3   
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 956 
                 Me 
                 Me 
                 Cl 
                 CF 3   
                 O 
                 3-Phenyl 
               
               
                 957 
                 Me 
                 Et 
                 Cl 
                 CF 3   
                 O 
                 3-Phenyl 
               
               
                 958 
                 Me 
                 iPr 
                 Cl 
                 CF 3   
                 O 
                 3-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 959 
                 (CH 2 ) 4   
                 Cl 
                 CF 3   
                 O 
                 3-Phenyl 
               
               
                 960 
                 (CH 2 ) 5   
                 Cl 
                 CF 3   
                 O 
                 3-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 961 
                 Me 
                 Me 
                 Cl 
                 CF 3   
                 Bond 
                 4-tBu-Phenyl 
               
               
                 962 
                 Me 
                 Et 
                 Cl 
                 CF 3   
                 Bond 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 963 
                 (CH 2 ) 4   
                 Cl 
                 CF 3   
                 Bond 
                 4-tBu-Phenyl 
               
               
                 964 
                 (CH 2 ) 5   
                 Cl 
                 CF 3   
                 Bond 
                 4-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 965 
                 Me 
                 Me 
                 Cl 
                 CF 3   
                 Bond 
                 3-tBu-4-Cl-Phenyl 
               
               
                 966 
                 Me 
                 Et 
                 Cl 
                 CF 3   
                 Bond 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 967 
                 (CH 2 ) 4   
                 Cl 
                 CF 3   
                 Bond 
                 3-tBu-4-Cl-Phenyl 
               
               
                 968 
                 (CH 2 ) 5   
                 Cl 
                 CF 3   
                 Bond 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 969 
                 Me 
                 Me 
                 Cl 
                 CF 3   
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 970 
                 Me 
                 Et 
                 Cl 
                 CF 3   
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 971 
                 (CH 2 ) 4   
                 Cl 
                 CF 3   
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 972 
                 (CH 2 ) 5   
                 Cl 
                 CF 3   
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 973 
                 Me 
                 Me 
                 Cl 
                 CF 3   
                 Bond 
                 3-tBu-Phenyl 
               
               
                 974 
                 Me 
                 Et 
                 Cl 
                 CF 3   
                 Bond 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 975 
                 (CH 2 ) 4   
                 Cl 
                 CF 3   
                 Bond 
                 3-tBu-Phenyl 
               
               
                 976 
                 (CH 2 ) 5   
                 Cl 
                 CF 3   
                 Bond 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 977 
                 Me 
                 Me 
                 OMe 
                 OMe 
                 O 
                 3-tBu-Phenyl 
               
               
                 978 
                 Me 
                 Et 
                 OMe 
                 OMe 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 979 
                 (CH 2 ) 4   
                 OMe 
                 OMe 
                 O 
                 3-tBu-Phenyl 
               
               
                 980 
                 (CH 2 ) 5   
                 OMe 
                 OMe 
                 O 
                 3-tBu-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 981 
                 Me 
                 Me 
                 OMe 
                 OMe 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 982 
                 Me 
                 Et 
                 OMe 
                 OMe 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 983 
                 (CH 2 ) 4   
                 OMe 
                 OMe 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
               
                 984 
                 (CH 2 ) 5   
                 OMe 
                 OMe 
                 O 
                 3-tBu-4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 985 
                 Me 
                 Me 
                 OMe 
                 OMe 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 986 
                 Me 
                 Et 
                 OMe 
                 OMe 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 987 
                 Me 
                 iPr 
                 OMe 
                 OMe 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 988 
                 (CH 2 ) 4   
                 OMe 
                 OMe 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 989 
                 (CH 2 ) 5   
                 OMe 
                 OMe 
                 O 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 990 
                 Me 
                 Me 
                 OMe 
                 OMe 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 991 
                 Me 
                 Et 
                 OMe 
                 OMe 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 992 
                 (CH 2 ) 4   
                 OMe 
                 OMe 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
               
                 993 
                 (CH 2 ) 5   
                 OMe 
                 OMe 
                 O 
                 3-CF 3 -5-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 994 
                 Me 
                 Me 
                 OMe 
                 OMe 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 995 
                 Me 
                 Et 
                 OMe 
                 OMe 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 996 
                 (CH 2 ) 4   
                 OMe 
                 OMe 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
               
                 997 
                 (CH 2 ) 5   
                 OMe 
                 OMe 
                 Bond 
                 3-CF 3 -4-Cl-Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 998 
                 Me 
                 Me 
                 OMe 
                 OMe 
                 Bond 
                 4-Me-Phenyl 
               
               
                 999 
                 Me 
                 Et 
                 OMe 
                 OMe 
                 Bond 
                 4-Me-Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 1000 
                 (CH 2 ) 4   
                 OMe 
                 OMe 
                 Bond 
                 4-Me-Phenyl 
               
               
                 1001 
                 (CH 2 ) 5   
                 OMe 
                 OMe 
                 Bond 
                 4-Me-Phenyl 
               
               
                   
               
            
           
         
       
     
     Table 3 gives some of the compounds according to the invention given in table 1 in their salt form. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE 3 
               
               
                   
               
               
                 No. 
                 Salt 
                 R 2   
                 R 3   
                 R 5   
                 A 
                 R 6   
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 34 
                 Trifluoromethane- 
                 Me 
                 Et 
                 Me 
                 O 
                 4-Cl-3-CF 3 -Phenyl 
               
               
                   
                 sulfonate 
               
               
                 366 
                 Hydrochloride 
                 Me 
                 Et 
                 Me 
                 O 
                 4-F-3-CF 3 -Phenyl 
               
               
                 371 
                 Trifluoroacetate 
                 Me 
                 Et 
                 Me 
                 O 
                 5-F-3-CF 3 -Phenyl 
               
               
                 371 
                 Trifluoroacetate 
                 Me 
                 Et 
                 Me 
                 O 
                 5-F-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
            
               
                 373 
                 Trifluoroacetate 
                 (CH 2 ) 5   
                 Me 
                 O 
                 5-F-3-CF 3 -Phenyl 
               
               
                 373 
                 Hydrobromide 
                 (CH 2 ) 5   
                 Me 
                 O 
                 5-F-3-CF 3 -Phenyl 
               
               
                 373 
                 Trifluoroacetate 
                 (CH 2 ) 5   
                 Me 
                 O 
                 5-F-3-CF 3 -Phenyl 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 538 
                 Acetate 
                 Me 
                 Et 
                 Me 
                 O 
                 2-Naphthyl 
               
               
                   
               
            
           
         
       
     
     For further characterization, log P data of some compounds are given in table 3. The log P data were determined in accordance with the EEC Directive 79/831 Annex V.A8 by HPLC (High Performance Liquid Chromatography) on a reversed-phase column (C18) using the following methods: 
     Temperature: 40° C.; Mobile Phase: 0.1% or 0.06% strength aqueous formic acid and 0.1% aqueous phosphoric acid and acetonitrile; linear gradient from 10% acetonitrile to 90% or 95% acetonitrile. 
     Calibration was carried out with the help of unbranched alkan-2-ones (consisting of 3 to 13 or 16 carbon atoms) with known logP values (determination of the logP values via the retention times by means of linear interpolation between two subsequent alkanones). 
     The lambda-max values were determined via the maxima of the chromatographic signals of the UV spectra from 190 nm to 400 or 450 nm. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE 4 
               
               
                   
               
               
                   
                   
                   
                   
                   
                   
                   1 H-CDCl 3 NMR 
               
               
                   
                   
                   
                   
                   
                   
                 (300 MHZ), 
               
               
                   
                   
                   
                   
                   
                 Melting point 
                 chemical shift 
               
               
                 No. 
                 log p acidic 
                 log p neutral 
                 log p HCO 2 H 
                 log p H 3 PO 4   
                 [° C.] 
                 in ppm 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                  1 
                 2.17 
                 5.11 
                   
                   
                   
                   
               
               
                  34 
                 2.38 
               
               
                  36 
                   
                 6.36 
                 2.59 
               
               
                 130 
                 2.05 
                 4.53 
               
               
                 226 
                 1.68 
               
               
                 228 
                 1.92 
                 5.35 
                 2.14 
               
               
                 250 
                   
                   
                 2.45 
               
               
                 286 
                   
                   
                 2.06 
               
               
                 290 
                 2.51 
               
               
                 321 
                 2.37 
                 6.21 
               
               
                 328 
                 2.70 
                 6.81 
               
               
                 345 
                   
                   
                 2.45 
               
               
                 356 
                 2.93 
                 7.01 
               
               
                 365 
                   
                   
                 2.37 
               
               
                 371 
                 2.31 
                 5.54 
               
               
                 373 
                 2.29 
               
               
                 373 (Trifluoroacetate) 
                 2.28 
               
               
                 373 (Hydrobromide) 
                 2.11 
               
               
                 388 
                   
                 6.70 
                 3.02 
               
               
                 393 
                 2.24 
                 5.62 
               
               
                 398 
                 2.27 
                 5.59 
               
               
                 401 
                   
                 7.36 
               
               
                 402 
                   
                 6.60 
                 2.96 
               
               
                 407 
                 2.18 
               
               
                 440 
                 2.96 
                   
                 2.72 
               
               
                 445 
                 2.71 
                 5.74 
               
               
                 446 
                 2.69 
                 6.30 
                   
                   
                 91 
               
               
                 494 
                   
                   
                   
                   
                   
                 1) 
               
               
                 498 
                   
                   
                   
                   
                   
                 2) 
               
               
                 502 
                 2.30 
               
               
                 547 
                 1.74 
                 4.33 
               
               
                 555 
                   
                   
                   
                 1.99 
               
               
                 50 
                 2.69 
                 5.96 
               
               
                 270 
                   
                   
                 2.21 
               
               
                 538 
                 2.38 
               
               
                 538 (Acetate) 
                 2.25 
               
               
                 559 
                 2.76 
               
               
                 916 
                 2.1 
                 4.92 
               
               
                 806 
                   
                 5.91 
                 2.79 
                 2.74 
               
               
                 986 
                 2.23 
                 4.14 
               
               
                 987 
                 2.35 
                 4.5 
               
               
                 999 
                 1.89 
               
               
                 998 
                 1.76 
               
               
                 836 
                 2.71 
                 5.74 
               
               
                 928 
                 2.3 
                 5.31 
               
               
                 892 
                   
                 5.08 
                 2.3 
                 2.35 
               
               
                 893 
                   
                 5.49 
                 2.44 
                 2.51 
               
               
                 894 
                   
                   
                 2.55 
                 1.73 
               
               
                 902 
                   
                 6.11 
                 2.65 
                 1.57 
               
               
                 903 
                   
                 6.54 
                 2.8 
                 2.98 
               
               
                 904 
                   
                 6.87 
                 3.01 
                 1.35 
               
               
                 880 
                   
                 5.44 
                 2.47 
                 2.63 
               
               
                 888 
                   
                 5.58 
                 2.45 
                 2.61 
               
               
                 875 
                   
                 5.51 
                 2.38 
                 2.56 
               
               
                 870 
                   
                 5.79 
                 2.55 
                 2.76 
               
               
                 884 
                   
                 5.86 
                 2.69 
                 2.87 
               
               
                 889 
                   
                 5.91 
                 2.62 
                 2.87 
               
               
                 871 
                   
                 5.84 
                 2.54 
                 2.79 
               
               
                 882 
                   
                 6.03 
                 2.66 
                 2.82 
               
               
                 891 
                   
                 6.21 
                 2.64 
                 2.82 
               
               
                 878 
                   
                 6.14 
                 2.62 
                 2.77 
               
               
                 873 
                   
                 6.42 
                 2.79 
                 3 
               
               
                 886 
                   
                 6.49 
                 2.78 
                 3.01 
               
               
                 862 
                 2.98 
               
               
                 906 
                   
                 7.04 
                 3.25 
                 3.36 
               
               
                 901 
                   
                 6.72 
                 3 
                 3.12 
               
               
                 899 
                   
                 6.45 
                 2.92 
                 3.07 
               
               
                 898 
                   
                 6.12 
                 2.78 
                 2.88 
               
               
                 816 
                   
                 5.56 
                 2.65 
                 2.6 
               
               
                 948 
                   
                 5.74 
                 2.98 
                 2.87 
               
               
                 846 
                 2.79 
               
               
                 854 
                 2.22 
               
               
                 949 
                   
                 6 
                 3.08 
                 2.82 
               
               
                 807 
                   
                 6.13 
                 2.82 
                 2.7 
               
               
                 951 
                   
                 6.2 
                 3.42 
                 3.03 
               
               
                 809 
                   
                 6.41 
                 3.04 
                 2.81 
               
               
                 830 
                 2.4 
               
               
                 817 
                   
                 5.88 
                 2.8 
                 2.74 
               
               
                 819 
                   
                 6.12 
                 3 
                 2.85 
               
               
                 811 
                   
                 6.64 
                 3.17 
                 3.16 
               
               
                 944 
                   
                 6.63 
                 3.39 
                 3.35 
               
               
                 812 
                   
                 6.81 
                 3.31 
                 3.35 
               
               
                 814 
                   
                 7.08 
                 3.62 
                 3.45 
               
               
                 946 
                   
                 7.1 
                 3.68 
                 3.61 
               
               
                 804 
                   
                 5.09 
                 2.12 
                 2.03 
               
               
                 802 
                   
                 4.84 
                 2.08 
                 2 
               
               
                 801 
                   
                 4.49 
                 1.91 
                 1.86 
               
               
                 957 
                   
                 4.71 
                 1.97 
                 2.07 
               
               
                 958 
                   
                 5.01 
                 2.08 
                 2.19 
               
               
                 960 
                   
                 5.26 
                 2.22 
                 2.29 
               
               
                 825 
                   
                 5.25 
                 2.56 
                 2.34 
               
               
                 826 
                   
                 5.61 
                 2.78 
                 2.53 
               
               
                 815 
                   
                 5.15 
                 2.45 
                 2.35 
               
               
                 947 
                   
                 5.39 
                 2.78 
                 2.61 
               
               
                 810 
                   
                 6.13 
                 2.94 
                 2.9 
               
               
                 912 
                   
                   
                 2.22 
               
               
                 761 
                 2.94 
               
               
                 799 
                 2.6 
               
               
                 608 
                 2.01 
                 5.31 
                 2.01 
                   
                 85.9 
               
               
                 615 
                   
                   
                   
                   
                  99-101 
               
               
                 651 
                   
                   
                   
                   
                 67-69 
               
               
                 721 
                 2.21 
               
               
                 584 
                   
                 6.54 
                 2.84 
               
               
                 585 
                   
                 6.34 
                 2.89 
               
               
                 583 
                   
                 6.09 
                 2.78 
               
               
                 962 
                 2.74 
                 6.15 
               
               
                 664 
                   
                   
                   
                 2.13 
               
               
                 663 
                   
                   
                   
                 2.04 
                 83   
               
               
                 665 
                   
                   
                   
                 2.22 
               
               
                 570 
                   
                 6.37 
                 2.95 
               
               
                 571 
                   
                 6.79 
                 3.03 
               
               
                 572 
                   
                 6.70 
                 2.87 
               
               
                 402 
                   
                 6.60 
                 2.96 
               
               
                 577 
                   
                 6.94 
                 3.24 
               
               
                 578 
                 3.06 
               
               
                 589 
                   
                 6.58 
                 2.84 
               
               
                 591 
                 3.21 
                 6.92 
               
               
                 590 
                 2.93 
                 7.01 
               
               
                 981 
                   
                 7.36 
                 3.11 
               
               
                 587 
                   
                 6.73 
                 2.74 
               
               
                 568 
                 2.86 
               
               
                 567 
                 2.66 
               
               
                 566 
                 2.83 
               
               
                 565 
                 2.64 
               
               
                 564 
                 2.51 
               
               
                 602 
                 1.65 
                 4.04 
               
               
                 603 
                 1.78 
                 4.52 
               
               
                 606 
                 1.79 
                 4.75 
               
               
                 596 
                 1.84 
                 4.41 
                 1.84 
               
               
                 597 
                 1.90 
                 5.09 
               
               
                 600 
                 1.90 
                 5.34 
               
               
                 573 
                 2.90 
                 7.14 
                 2.90 
               
               
                 579 
                 3.19 
                 7.36 
                 3.19 
               
               
                 697 
                 2.67 
               
               
                 733 
                 2.75 
               
               
                 669 
                 2.38 
               
               
                 673 
                 2.23 
               
               
                 656 
                 2.37 
               
               
                 610 
                 2.21 
                   
                 2.21 
               
               
                 681 
                 1.32 
               
               
                 612 
                 1.72 
               
               
                 614 
                 1.98 
               
               
                 620 
                   
                   
                 2.20 
               
               
                 622 
                   
                   
                 2.41 
               
               
                 681 
                 1.32 
               
               
                   
               
               
                 NMR data: 
               
               
                 1) Re example No. 494: 2.5 (Me-butenyl radical). 3 (Me-amidine), 5.07-5.17 (m, CH 2 -olefinic butenyl) 
               
               
                 2) Re example No. 498: 1.19-1.28 (triplet CH 2  from OEt), 2.51 (Me-butenyl radical), 3 (Me-amidine), 4.94-5.0 (m, CH 2 -olefinic butenyl). 
               
            
           
         
       
     
     A. FORMULATION EXAMPLES 
     1. Dusting Agent 
     A dusting agent is obtained by mixing 10 parts by weight of a compound of formula (I) and 90 parts by weight of talc as inert substance and comminuting in a hammer mill. 
     2. Dispersible Powder 
     A wetable powder that is readily dispersible in water is obtained by mixing 25 parts by weight of a compound of formula (I), 64 parts by weight of kaolin-containing quartz as inert substance, 10 parts by weight of lignosulfonic potassium and 1 part by weight of oleoylmethyltauric sodium as wetting agent and dispersant and grinding in a pin mill. 
     3. Dispersion Concentrate 
     A dispersion concentrate that is readily dispersible in water is obtained by mixing 20 parts by weight of a compound of formula (I), 6 parts by weight of alkylphenol polyglycol ether (®Triton X 207), 3 parts by weight of isotridecanol polyglycol ether (8 EO) and 71 parts by weight of paraffinic mineral oil (boiling range e.g. ca. 255 to above 277° C.) and grinding to a fineness of below 5 microns in a friction ball mill. 
     4. Emulsifiable Concentrate 
     An emulsifiable concentrate is obtained from 15 parts by weight of a compound of formula (I), 75 parts by weight of cyclohexanone as solvent and 10 parts by weight of oxethylated nonylphenol as emulsifier. 
     5. Water-Dispersible Granules 
     Water-dispersible granules are obtained by mixing 
                                            75 parts by weight of a compound of formula (I),           10 parts by weight of calcium lignosulfonate,            5 parts by weight of sodium lauryl sulfate,            3 parts by weight of polyvinyl alcohol and            7 parts by weight of kaolin,                        
grinding on a pin mill and granulating the powder in a fluidized bed by spraying on water as granulation liquid.
 
     Water-dispersible granules are also obtained by homogenizing and precomminuting 
                                25 parts by weight of a compound of formula (I),        5 parts by weight of sodium 2.2′-dinaphthylmethane-6.6′-disulfonate,        2 parts by weight of sodium oleoylmethyltaurate,        1 parts by weight of polyvinyl alcohol,       17 parts by weight of calcium carbonate and       50 parts by weight of water                    
on a colloid mill, then grinding on a bead mill and atomizing and drying the suspension obtained in this way in a spray tower using a single-material nozzle.
 
     B. BIOLOGICAL EXAMPLES 
     1. Herbicidal Effect in the Preemergence Phase 
     Seeds of mono- and dicotyledonous broad-leaved weeds and crop plants are planted in wood-fiber pots in sandy loamy earth and covered with earth. The compounds of formula (I) formulated in the form of wettable powders (WP) or as emulsion concentrates (EC) are then applied to the surface of the covering earth as an aqueous suspension at a water application rate of converted 800 l/ha with the addition of 0.2% wetting agent. 
     Following treatment, the pots are placed in the greenhouse and kept under good growing conditions for the test plants. The visual assessment of the damage to the experimental plants was made after an experimental time of 3 weeks compared to untreated controls (herbicidal effect in percent (%): 100% effect=plants have died, 0% effect=as control plants). Here, the compounds at an application rate of 1.28 kg/ha for example exhibited in each case at least 80% effect against the harmful plants named in each case: 
     No. 114 against DIGSA, SETVI, CHEAL and VERPE,
 
No. 290 against DIGSA, AMARE, SETVI and VERPE,
 
No. 306 against SETVI, AMARE, MATCH and VERPE,
 
No. 345 against DIGSA, SETVI, CHEAL and MATCH,
 
No. 362 against DIGSA, SETVI and VERPE,
 
No. 364 against DIGSA, SETVI, ABUTH, AMARE, VERPE and VIOSS,
 
No. 478 against ECHCG, SETVI and VERPE,
 
No. 506 against ABUTH, VERPE and VIOSS,
 
No. 547 against DIGSA, ECHCG, SETVI, AMARE, CHEAL, GALAP and VIOSS,
 
No. 761 against SETVI, ABUTH, AMARE, VERPE, ECHCG,
 
No. 799 against SETVI, ABUTH, PHBPU, VERPE and VIOSS,
 
No. 893 against ECHCG, SETVI, AMARE, VERPE and VIOSS,
 
No. 894 against ECHCG, SETVI, AMARE, MATCH and VERPE,
 
No. 904 against SETVI, AMARE and VIOTR,
 
No. 962 against ECHCG, SETVI, ABUTH, AMARE, VERPE and VIOSS.
 
     2. Herbicidal Effect in the Postemergence Phase 
     Seeds of mono- and dicotyledonous broad-leaved weeds and crop plants are planted in wood-fiber pots in sandy loamy soil, covered with earth and grown in the greenhouse under good growing conditions. 2 to 3 weeks after seeding, the experimental plants are treated at the one-leaf stage. The compounds of formula (I) formulated in the form of wettable powders (WP) or as emulsion concentrates (EC) are then sprayed onto the green plant parts in the form of an aqueous suspension at a water application rate of converted 800 l/ha with the addition of 0.2% wetting agent. After a standing time of the experimental plants in the greenhouse for ca. 3 weeks under optimal growing conditions, the effect of the preparation is assessed visually compared to untreated controls (herbicidal effect in percent (%): 100% effect=plants have died, 0% effect=as control plants). In this connection, for example the compounds at an application rate of 1.28 kg/ha exhibited in each case at least an 80% effect against the harmful plants specified in each case: 
     No. 36 against ABUTH, AMARE, CHEAL, PHBPU, VERPE and XANST,
 
No. 130 against ABUTH and VERPE,
 
No. 290 against ECHCG, ABUTH, AMARE, CHEAL, PHBPU, VERPE and SETVI,
 
No. 362 against ECHCG, ABUTH, AMARE, CHEAL, PHBPU and VERPE,
 
No. 364 against ECHCG, ABUTH, AMARE, CHEAL, PHBPU, VERPE and SETVI,
 
No. 365 against ECHCG, CHEAL, GALAP, PHBPU and POLSS,
 
No. 371 against ABUTH, GALAP, PHBPU and VERPE,
 
No. 401 against ECHCG, ABUTH, AMARE, VERPE, VIOSS and XANST,
 
No. 474 against ABUTH, AMARE, GALAP, PHBPU, VERPE and VIOSS,
 
No. 506 against VERPE and VIOSS,
 
No. 522 against VERPE and VIOSS,
 
No. 530 against AMARE, VERPE and VIOSS,
 
No. 761 against SETVI, ABUTH, AMARE, PHBPU, VERPE, VIOSS,
 
No. 799 against ABUTH, AMARE, PHBPU, VERPE and VIOSS,
 
No. 836 against AMARE, MATCH, PHBPU, VERPE, VIOSS and XANST,
 
No. 893 against SETVI, ABUTH, AMARE, VERPE and VIOSS,
 
No. 894 against SETVI, ABUTH, AMARE, MATCH, PHBPU and VIOSS,
 
No. 904 against ABUTH, AMARE, PHBPU and VIOSS,
 
No. 962 against ECHCG, ABUTH, AMARE, PHBPU, VERPE and VIOSS.
 
     The abbreviations mean 
     
       
         
           
               
               
               
               
             
               
                   
               
             
            
               
                 ABUTH 
                 
                   Abutilon theophrasti 
                 
                 AMARE 
                 
                   Amaranthus retroflexus 
                 
               
               
                 CHEAL 
                 
                   Chenopodium album 
                 
                 DIGSA 
                 
                   Digitaria sanguinalis 
                 
               
               
                 ECHCG 
                 
                   Echinochloa crus galli 
                 
                 GALAP 
                 
                   Galium aparine 
                 
               
               
                 MATCH 
                 
                   Matricaria 
                 
                 PHBPU 
                 
                   Pharbitis purpureum 
                 
               
               
                   
                 
                   chamomilla 
                 
                 VERPE 
                 
                   Veronica persica 
                 
               
               
                 SETVI 
                 
                   Setaria viridis 
                 
                 XANST 
                 
                   Xanthium strumarium 
                 
               
               
                 VIOSS 
                   Viola  spec.