Patent Publication Number: US-2005143683-A1

Title: Lymphedema treatment system

Description:
This application is a continuation-in-part of co-pending application Ser. No. 09/730,081 filed Dec. 05, 2000 which is a continuation-in-part of U.S. Pat. No. 6,179,796 filed Apr. 11, 1997. 
    
    
     BACKGROUND OF THE INVENTION  
      1.  
      Field of the Invention  
      This invention relates to apparatus and method for the treatment of lymphedema. More particularly it relates to a wrap having a series of bladders applied to the trunk of the body, wherein the bladders are compressed and decompressed on an individual basis to stimulate the lymphatic system.  
      2. Description of the Prior Art  
      The lymphatic system consists of lymph vessels, lymph nodes and lymphoid tissues and is a secondary system within the circulatory system that removes waste. Unlike the closed-loop blood circulatory system, the lymphatic system works according to a one-way principal. That is, the lymphatic system is a drainage system to drain away lymph which continually escapes from the blood in small amounts. The lymph is first collected at the lymph capillaries, which in turn drain into larger vessels. The lymph is pumped in and out of these vessels by movements of adjacent muscles and by contractions of the walls of the larger vessels, and moves through the lymphatic system in one direction. Foreign matter and bacteria are filtered at various lymph node groups after which the fluid empties into the venous portion of the blood system, mainly through the thoracic duct. A healthy person will drain one to two liters of lymph fluid through this duct every 24 hours. Without proper drainage into the duct, lymphedema results.  
      Lymphedema is an accumulation of a watery fluid in the body causing a swelling or edema of the affected area. The swelling causes pain, discomfort, disfigurement and interference with wound healing and, if left untreated, can cause fibrosis. Fibrosis is a hardening of the tissue in the affected area which may further complicate the drainage process and can cause life-threatening conditions, such as infections. Lymphedema may result from surgery when the lymph nodes are removed in order to prevent the further spread of cancerous conditions, such as with a mastectomy or prostectomy, and may also be caused by filariasis. Lymphedema may be primary or congenital.  
      In recent years, several common therapies for lymphedema have been proposed. Special bandages, such as a limb compression sleeve or stocking, have been utilized to help prevent accumulation of fluid in a limb by holding the tissue tightly. This treatment is incomplete, however, because it treats the limb only and does nothing to actually move the fluid. This treatment is also uncomfortable (and may be painful) and is not easily adaptable to the trunk of the body. In application to the limb, this treatment may interfere with mobility.  
      Pneumatic compression devices have also been used to assist limb lymph drainage by increasing the tissue pressure, thus, forcing fluid along the lymphatic system. This treatment approach, however, is incomplete because it treats the limb only. This treatment approach may cause fibrosis or accumulation of fluids in non-affected areas. The high pressure required to force the fluid along the system is uncomfortable or painful, while lower pressure devices result in an increase in therapeutic time.  
      Another approach is manual lymph drainage (MLD), a gentle manual treatment technique which improves lymphatic system functioning through a highly specific massage, which provides mild mechanical stimuli to the lymphatic system. MLD has the advantage of being able to treat the entire lymphatic system, including the arms, legs and trunk of the body. The MLD treatment technique applies just enough pressure to massage pooled fluids from larger areas toward specific lymph nodes within the body by mechanically stimulating the lymphatic system to cause contraction of the lymph collectors sufficient to help move the pooled fluids by promoting reabsorption of the pooled fluids within the surrounding tissues. Too much applied pressure will cause the lymph collectors to go into spasm. This technique is effective but also expensive, however, as a person trained in the MLD technique is required to perform the massage therapy.  
      U.S. Pat. No. 5,453,081, issued to Hansen, suggests an apparatus for generating air pressure pulses which are delivered to a vest or mattress accommodating a person. A diaphragm located within a housing is connected to a wave generator and amplifier operable to vibrate the diaphragm. The vibrating diaphragm produces air pressure pulses, which are delivered to the air accommodating receiver, and which subject the person to repetitive force pulses. The housing has an enclosed chamber accommodating the diaphragm, which divides the chamber into two separate portions, wherein air under pressure may be supplied with a pump to the chamber to pressurize the apparatus, as well as the receiver. A coil connected to the diaphragm is operable to vibrate the diaphragm to pulsate air in the chamber.  
      U.S. Pat. No. 5,437,610, issued to Cariapa et al., suggests a portable hydraulic extremity pump apparatus for the treatment of edema. This apparatus consists of a flexible compression unit that wraps around an individuals extremity. The unit includes a plurality of prefilled bladders, each containing a separate compression bladder which are connected to a hydraulic pump through valves. The valves, pump, and pressure sensors, which connect to the prefilled bladders, all connect to a programmable control processor to operate the valves and to pump and monitor the bladder pressures. The occurrence of edema is detected by monitoring an increase in pressure in the prefilled bladders. Once edema is detected, the control processor activates the pump and opens valves connected to the compression bladder in a sequential manner to create a sequential pressurization and wave of compression moving proximally on the extremity.  
      U.S. Pat. No. 5,052,377, issued to Frajdenrajch, suggests an apparatus for massaging parts of the body by sequential cyclic pressure having a massaging boot comprising a plurality of juxtaposed inflatable cells. An inflating conduit is connected to each cell through a series of distributors for receiving a control fluid. Each distributor has a movable membrane arranged to permit passage of the inflating fluid in a downstream direction when the local inflating pressure reaches a value which is a function of the pressure of the control fluid. The cells are inflated in series, one after another, and then deflated in a cyclic manner.  
      U.S. Pat. No. 5,014,681, issued to Neeman et al., suggests a method and apparatus for treating a body part by applying intermittent compression through an inflatable sleeve applied to and enclosing the body part. The inflatable sleeve is divided into successively overlapping inflatable cells. Pressurized fluids are applied cyclically to successive groups of cells to successively inflate each group, while at the same time deflating a preceding group. As successive groups of cells are inflated (while the remaining cells are deflated), a compression wave is introduced in the sleeve which subjects successive portions of the body part to compression.  
      U.S. Pat. No. 4,573,453, issued to Tissot, suggests a pneumatic massage apparatus which includes an inflatable sleeve having an inner and outer sheath with lateral partition walls extending between the inner and outer sheaths. The inner and outer sheaths are formed of air-impermeable, non-elastic material and the lateral partition walls are formed of a flexible air-impermeable, non-elastic material. The partition walls and inner and outer sheaths define separate inflatable chambers, adjacent chambers being separated by a partition wall. When a first chamber has been inflated, its feed conduit is closed and the following chambers are inflated in turn to the same feed pressure. The result causes a deformation of the walls of the first chamber, and a slight increase in the internal pressure in this first chamber. Step by step, with the same feed pressure, the appearance of a pressure gradient is created.  
      U.S. Pat. No. 2,361,242, issued to Rosett, suggests a pneumatic suit or garment adapted to be applied to limbs of a patient, wherein the pneumatic suit has a series of laterally disposed pockets, each of which is provided with a fluid-type flexible bag. The bags are inflated one after another in groups, so as to cause the exertion of waves of pressure from the extremities of the limbs and from the lower portion of the torso of the patient towards the region of the heart. After each bag is inflated, it is immediately subjected to a source of sub-atmospheric pressure to accelerate the removal of air therefrom and to accentuate the effect. Rosett suggests the pneumatic suit or garment being applied to areas including the arms and legs and lower trunk.  
      U.S. Pat. No.  5 , 626 , 556 , issued to Tobler et al., is generally directed to the radio frequency welding of a VELCRO component to a compression sleeve, an alternative to fastening same by sewing. Tobler et al. generally show a compression sleeve of symmetrical design for the leg which includes a series of pneumatically paired or linked chambers (i.e., ankle chambers  38   a / 38   b,  calf chambers  38   c / 38   d,  and thigh chambers  38   e / 38   f ). Each pneumatically paired chamber includes a ventilation channel or plenum which partially traverses the chamber, thereby defining a bifurcated end for each pneumatically paired chamber. The ventilation plenums are intended to cool the underlaying leg via continuous air circulation thereto.  
     SUMMARY OF THE INVENTION  
      The present invention provides an apparatus for mechanical stimulation of the lymphatic system for the treatment of lymphedema. A lymphedema treatment system in accordance with the present invention includes a wrap having a plurality of elongate and flexible bladders applied to the trunk of the body. The bladders are compressed and decompressed on an individual basis to stimulate the lymphatic system to provide for drainage of pooled fluids by massaging the pooled fluids within the trunk section of the body towards lymph nodes in the neck or groin of the body. Compression and decompression of the bladders may be provided by a pump.  
      In a preferred embodiment of the present invention, the apparatus for the treatment of lymphedema may comprise a plurality of elongate and flexible bladders, wherein the plurality of bladders has an orientation adopted to engage the trunk of the body and move pooled fluids within the lymphatic system towards a particular region of the body or away from a particular region of the body. The particular regions of the body may be specific lymph node groups which include the axillary node group, the pelvic node group or the groin node group as well as the thoracic duct. The orientation of the plurality of bladders relative to the particular region may be arcuate so that the plurality of bladders being coextensive and sequentially arranged in a fixed relation may engage the trunk of the body to radially move the pooled fluids within the lymphatic system to the particular region of the body.  
      In a preferred embodiment, each particular one of the plurality of bladders may be sequentially pressurized and depressurized in a sequence to provide mechanical stimulation of the lymphatic system similar to Manual Lymph Drainage (MLD) massage. In the preferred embodiment, a pumping system is in fluid communication with each particular one of the plurality of bladders and is programmable to sequentially pressurize and depressurize each particular one of the plurality of bladders. The pumping system may be comprised of a pneumatic pump and a plurality of pneumatic hoses to couple the pneumatic pump to each particular one of the plurality of bladders. Each particular one of the plurality of bladders may be pressurized to engage the trunk of the body at a therapeutic pressure. The lymphatic system is mechanically stimulated when each particular one of the plurality of bladders being both pressurized to the therapeutic pressure and depressurized causes contraction of lymph collectors sufficient to move pooled fluids by promoting reabsorption of the pooled fluids within the surrounding tissues without causing the lymph collectors to go into spasm. In the preferred embodiment there may be a predetermined waiting period between a first particular one of the plurality of bladders being fully pressurized and fully depressurized (i.e., a set, pre-determined period from the start of pressurization to a return to atmospheric condition). In addition, depressurization of the first particular one of the plurality of bladders may begin before pressurization of a second particular one of the plurality of bladders begins.  
      The preferred embodiment may further comprise a wrap sized to wrap around a portion of the trunk of the body to receive and hold each one of the plurality of bladders within a corresponding one of a plurality of compartments. The plurality of bladders are held in an orientation to engage the trunk of the body and move pooled fluids within the lymphatic system either towards or away from specific lymph node groups which include the axillary node group, the pelvic node group or the groin node group. The orientation may be arcuate relative to the particular lymph node group. The wrap may maintain the plurality of bladders in a coextensive relationship such that each particular one of the plurality of bladders is adjacent to one or two other ones of the plurality of bladders. The wrap may be constructed of a stretchable material to accommodate expansion and contraction of the bladders as the bladders are sequentially pressurized and depressurized. The wrap may also limit the maximum diameter under pressurization of each one of the plurality of bladders within the plurality of compartments.  
      The present invention further provides a method of body manipulation in furtherance of treating lymphedema. The method includes providing a wrap adapted to fit about a body extremity and applying same about the body extremity, more particularly, providing and applying a wrap having a trunk region and limb regions, and a plurality of compartments distributed throughout the regions. Each of the compartments of the plurality of compartments of the wrap regions is capable of selective pressurization and depressurization, as by use of a controllable pneumatic system, or the like, known to those of skill in the art. The method further includes preparing the body extremity for receipt of lymph fluid via a first pressurization and depressurization sequence of select compartments within select regions of the regions of the wrap, and draining lymph fluid from the body extremity via a second pressurization and depressurization sequence of select compartments within select regions of the regions of said wrap. By this method, the lymphatic system is stimulated so as to promote reabsorption of pooled lymph fluid within surrounding tissue. 
    
    
     BRIEF DESCRIPTION OF THE DRAWINGS  
      Other objects of the present invention and many of the attendant advantages of the present invention will be readily appreciated as the same becomes better understood by reference to the following detailed description when considered in connection with the accompanying drawings, in which like reference numerals designate like parts throughout the figures thereof and wherein:  
       FIG. 1  is a perspective view of the preferred embodiment of a “Lymphedema Treatment System” in accordance with the present invention;  
       FIG. 2  is a perspective view of the human body showing specific lymph node groups and the thoracic duct;  
       FIG. 3  is a detailed cross-section view of the embodiment of  FIG. 1  showing various levels of bladder pressurization;  
       FIG. 4  is a detailed cross-section view of the embodiment of  FIG. 1  showing the means to provide bladder pressurization;  
       FIG. 5  is a perspective view showing an alternate embodiment in accordance with the present invention;  
       FIG. 6  is a perspective view showing a further alternate embodiment in accordance with the present invention;  
       FIG. 6A  shows a preferred wrap, about a upper body extremity, for practicing the method of the subject invention;  
       FIG. 7  shows a preferred wrap, about a lower body extremity, for practicing the method of the subject invention, with structures thereof delimited for the sake of discussion; and  
       FIGS. 8A-8E  depict the general steps associated with the preparation of a lower body extremity and drainage of lymph fluid therefrom via the method of the present invention.  
       FIG. 9  illustrates a wrap assembly about an upper body extremity with a series of flow lines indicating drainage towards lymph nodes;  
       FIG. 10  illustrates an arm wrap, more particularly the upper extremity left arm wrap of  FIG. 9  in an “unwrapped” or flat condition;  
       FIG. 10A  illustrates a cover for the wrap of  FIG. 10 , more particularly a panel for overlaying the pressurization ports of the wrap;  
       FIG. 11  illustrates a chest wrap, more particularly the upper extremity left chest wrap of  FIG. 9  in an “unwrapped” or flat condition;  
       FIGS. 11A &amp; 11B  illustrate straps for securing the wrap of  FIG. 11 ;  
       FIG. 11C  illustrates a cover for the wrap of  FIG. 11 , more particularly a panel for overlaying the pressurization ports of the wrap;  
       FIG. 12  illustrates a wrap assembly about an lower body extremity with a series of flow lines indicating drainage towards lymph nodes;  
       FIGS. 13A &amp; 13B  illustrate cooperative portions of the calf-foot wrap of  FIG. 12  in an “unwrapped” or flat condition;  
       FIGS. 14A &amp; 14B  illustrate cooperative portions of the thigh-trunk wrap of  FIG. 12  in an “unwrapped” or flat condition;  
       FIG. 15  is a specific illustration of the wrap element of  FIG. 13A ;  
       FIG. 16  is a specific illustration of the wrap element of  FIG. 13B ;  
       FIG. 17  illustrates a cover for the wrap element of FIGS.  15 / 16 , more particularly a panel for overlaying the pressurization ports of the wrap element;  
       FIG. 18  is a specific illustration of the wrap element of  FIG. 14A ;  
       FIG. 19  is a specific illustration of the wrap element of FIG.  14 B;  
       FIG. 20  illustrates a cover for the wrap element of FIGS.  18 / 19 , more particularly a panel for overlaying the pressurization ports of the wrap element; and,  
       FIG. 21  depicts a partial longitudinal section of a tubular chamber of the subject wrap structure, particularly illustrating the nature of the composite material panel. 
    
    
     DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS  
      Referring now to the drawings, wherein like reference numerals refer to like elements throughout the several views,  FIG. 1  is a perspective view of a preferred embodiment of a lymphedema treatment system in accordance with the present invention. The lymphedema treatment system is shown generally at  10  and consists of a wrap  12  and a pneumatic pump  14 . Wrap  12  is shown applied to lower trunk  16  of human body  18 . Wrap  12  is positioned on lower trunk  16  by placement on human body  18  when in an open position, then pulling first end  20  over second end  22  until wrap  12  is firmly and completely engaging lower trunk  16 . Wrap  12  is then secured by attaching first end  20  to second end  22  through fasteners well known in the art, such as Velcro (not shown). Wrap  12  is comprised of compartments  24 ,  26 ,  28 ,  30 ,  32 ,  34 ,  36 ,  38 ,  40  and  42 . Each one of compartments  24 ,  26 ,  28 ,  30 ,  32 ,  34 ,  36 ,  38 ,  40  and  42  is sized to receive and hold a particular one of a plurality of elongate and flexible bladders  44 ,  46 ,  48 ,  50 ,  52 ,  54 ,  56 ,  58 ,  60  and  62 , respectively. In the preferred embodiment, compartments  36 ,  38 ,  40  and  42  and bladders  56 ,  58 ,  60  and  62  are not required, but are shown here to illustrate that many configurations of wrap  12  are within the scope of the present invention. Each of bladders  44 ,  46 ,  48 ,  50 ,  52 ,  54 ,  56 ,  58 ,  60  and  62  are in fluid communication with pneumatic pump  14  via pneumatic hoses  45  where pneumatic pump  14  is both portable and programmable and may be programmed to individually and sequentially pressurize and depressurize each particular one of the plurality of bladders in a desired sequence (see also,  FIG. 4 ). Pneumatic hoses  45  comprise a plurality of hoses wherein each hose couples one of the bladders to pneumatic pump  14 . The desired sequence provides individual sequential pressurization and depressurization of each one of bladders  44 ,  46 ,  48 ,  50 ,  52 ,  54 ,  56 ,  58 ,  60  and  62  to provide mechanical stimulation of the lymphatic system similar to manual lymph drainage massage. Pneumatic pump  14  pressurizes each one of bladders  44 ,  46 ,  48 ,  50 ,  52 ,  54 ,  56 ,  58 ,  60  and  62  to a maximum inflation pressure of 5 PSI (approximately 260 mm Hg) where at the maximum inflation pressure each bladder is elastic and has a diameter from 0.5 inches to 2 inches. In the preferred embodiment, wrap  12  is constructed of a stretchable material to accommodate expansion and contraction of each one of bladders  44 ,  46 ,  48 ,  50 ,  52 ,  54 ,  56 ,  58 ,  60  and  62  and limits the maximum diameter of each bladder.  
      In the preferred embodiment, bladders  44 ,  46 ,  48 ,  50 ,  52 , and  54  are held within compartments  24 ,  26 ,  28 ,  30 ,  32 , and  34  of wrap  12  so that the bladders have a generally arcuate shape and are sequentially pressurized and depressurized to engage lower trunk  16  of human body  18  to radially move pooled fluids. The pooled fluids are moved within the lymphatic system of human body  18  either in the direction shown by arrows  64 ,  66  and  68 , or in a direction opposite to the direction shown by arrows  64 ,  66  and  68 . The bladders are oriented to be arcuate relative to three lymph node groups such that radial lines extending from each bladder converge (or diverge) towards each one of the lymph node groups (see also,  FIG. 2 ). Bladders  44 ,  46 ,  48 ,  50 ,  52 , and  54 , each being sequentially pressurized and depressurized, engage lower trunk  16  of human body  18  at a therapeutic pressure to provide mechanical stimulation of the lymphatic system. This mechanical stimulation provides for drainage of pooled fluids within the lymphatic system by applying the therapeutic pressure to lower trunk  16  of human body  18  sequentially to move the pooled fluids either towards or away from the selected lymph node groups within the neck or groin of the body by promoting reabsorption in the surrounding tissues. If the applied pressure is too high, the lymph collectors may go into spasm. In the preferred embodiment, the therapeutic pressure measured between the bladders and the body is between 20 mm Hg and 45 mm Hg.  
      In the preferred embodiment, there is a predetermined waiting period of one to three seconds between pressurization and depressurization of each bladder (i.e., the period from the start of pressurization to a return to an atmospheric condition), more than a single bladder being at a pressure greater than-atmospheric during the sequenced mechanical stimulation. Thus, each of bladders  44 ,  46 ,  48 ,  50 ,  52 , and  54  are pressurized for one to three seconds to provide the mechanical stimulation to the lymphatic system. Each bladder is depressurized before pressurization of the next bladder begins. In  FIG. 1 , for example, bladder  44  would be depressurized before bladder  46  is pressurized. Each of bladders  44 ,  46 ,  48 ,  50 ,  52 , and  54  are pressurized to apply the therapeutic pressure over a time period which is a predetermined minimum pressurization time period, and are depressurized over a time period which is a predetermined minimum depressurization time period. It is understood that the embodiment shown in  FIG. 1  is just one of many possible configurations of a lymphedema treatment system in accordance with the present invention.  
       FIG. 2  is a perspective view of the human body showing the location of specific lymph node groups. The lymph node groups shown in  FIG. 2  do not comprise all the lymph node groups within human body  18 , but are representative and described for illustrative purposes.  FIG. 2  shows axillary node group  80 , pelvic node group  82  including a portion of the thoracic duct, and groin node group  84  and diverging arrows  64 ,  66  and  68 . An application of wrap  12  as shown in  FIG. 1  provides for drainage of pooled fluids by massaging the pooled fluids in the direction shown by arrow  64  towards axillary node group  80 , in the direction-shown by arrow  66  towards pelvic node group  82 , and in the direction shown by arrow  68  towards groin node group  84 . In the human body, the lymph capillaries reabsorb tissue fluid and drain through precollectors to the lymph angions. The lymph angions contract in sequence to help move the fluid along the lymphatic system. The application of the wrap, as shown in  FIG. 1 , stimulates this natural drainage through sequentially pressurizing and depressurizing each particular one of bladders  44 ,  46 ,  48 ,  50 ,  52 , and  54  to stimulate the initial lymph capillaries and provide for contraction of the lymph angions. Pooled fluids may be moved to axillary node group  80 , pelvic node group  82 , or groin node group  84 , where foreign matter and bacteria are filtered out and the fluid is emptied into the venous portion of the human body blood system.  
       FIG. 3  is a detailed cross-sectional view of a preferred embodiment in accordance with the present invention showing the construction of wrap  12  and various levels of bladder pressurization.  FIG. 3  shows a portion of wrap  12  comprising bladders  44 ,  46  and  48 . Bladders  44 ,  46  and  48  may each be constructed of an elastic material to provide stretchability when going from a depressurized state to a fully pressurized state. Bladder  44  is shown in a fully pressurized state, bladder  46  is shown in a partially pressurized state, and bladder  48  is shown in a depressurized state.  
      Compartments  24 ,  26  and  28  are constructed of a combination of materials. A first layer  90  overlays each of bladders  44 ,  46  and  48  and is the side of wrap  12  that is in a contact relationship with lower trunk  16  of human body  18 . First layer  90  is preferably constructed of a stretchable material and stretches when any of bladders  44 ,  46  or  48  are fully pressurized to provide the therapeutic pressure to lower trunk  16 . The therapeutic pressure is between 20 mm Hg and 45 mm Hg (0.387 and 0.87 psi). Second layer  92  overlays each of bladders  44 ,  46  and  48  on the side of wrap  12  opposite first layer  90 . Second layer  92  is preferably constructed of a durable cotton material. Third layer  94  overlies second layer  92  and provides an outer cover for wrap  12 . Third layer  94  is preferably constructed of a cotton material.  
       FIG. 4  is a detailed cross-section view showing the means to provide bladder pressurization. Pneumatic pump  14  is coupled to and is in fluid communication with each of bladders  44 ,  46  and  48  via couplings  96 ,  98  and  100 , respectively. Couplings  96 ,  98  and  100  couple to pneumatic hoses  45  allowing pneumatic air pressurization to be applied individually and sequentially to bladders  44 ,  46 , and  48  to pressurize and depressurize each bladder. In  FIG. 4 , pneumatic hoses  45  comprise at least three hoses wherein each hose couples one of couplings  96 ,  98  or  100  to pneumatic pump  14 .  
       FIG. 5  is a perspective view showing another embodiment of the present invention. Wrap  110  is shown being applied to an upper trunk  112  of human body  18 . Wrap  110  has compartments  114 ,  116 ,  118 ,  120 ,  122  and  124  containing bladders  126 ,  128 ,  130 ,  132 ,  134  and  136 , respectively. Pneumatic pump  14  is not shown. Bladders  126 ,  128 ,  130 ,  132 ,  134  and  136  may be sequentially pressurized and depressurized to provide movement of pooled fluids within the lymphatic system towards axillary node group  80  in the direction shown by arrows  138 ,  140 , and  142 .  
      Bladders  126 ,  128 ,  130 ,  132 ,  134  and  136  when pressurized and depressurized provide a gentle massaging action which provides a mechanical stimulation similar to manual lymph drainage massage to the lymphatic system so that proper drainage may occur. The stimulus is provided by sequential inflation of each bladder. The therapeutic pressure is measured between bladders  126 ,  128 ,  130 ,  132 ,  134  and  136  and upper trunk  112  and is between 20 mm Hg and 45 mm Hg (0.387 and 0.87 psi) in order to promote reabsorption from the surrounding tissues. Too much pressure against upper trunk  112  will cause the lymph collectors to go into spasm and reduce effectiveness. The plurality of bladders may be individually and sequentially pressurized and depressurized in the direction shown by radial arrows  138 ,  140 , and  142  (converging toward axillary node group  80 ) to promote drainage of fluids in a direction towards axillary group  80 . In terms of the present invention, the bladders  126 ,  128 ,  130 ,  132 ,  134  and  136  are “oriented” (configured and sequentially pressurized and depressurized) to direct drainage in a direction towards axillary group  80 . The bladder configuration is generally arcuate, while the “radial” arrows  138 ,  140  and  142  point in a direction generally perpendicular to a tangent of the arcuate bladder.  
       FIG. 6  is a perspective view showing a further embodiment in accordance with the present invention, more particularly a wrap  110  applied to upper trunk  112  of human body  18 . Wrap  110  may undergo sequential pressurization and depressurization of bladders  126 ,  128 ,  130 ,  132 ,  134  and  136  to move pooled fluids away from axillary node group  80  towards other node groups, such as pelvic node group  82  and groin node group  84  (see  FIG. 2 ).  
      The figures illustrate that alternative constructions in accordance with the present invention may move pooled fluids within human body  18  from several regions to a particular node group, or from a particular region to several node groups, for instance, with reference to  FIG. 6 , pooled fluids may be moved within the lymphatic system in a direction generally away from axillary node group  80  in the direction shown by arrows  150 ,  152 ,  154 , and  156  through the configuration of, and through sequential pressurization and depressurization of, bladders  126 ,  128 ,  130 ,  132 ,  134  and  136 . A more detailed presentation and discussion of the preferred method of the present invention is found hereafter, in accordance with treatment of a lower body extremity, more particularly the preparation and drainage of lymph fluid therefrom as depicted in  FIGS. 8A-8E  using, for example, the wrap of  FIG. 7 .  
      Each bladder of the illustrated embodiments has a generally arcuate configuration. The configuration and sequential pressurization/depressurization provides an orientation towards one or more node group(s). That is, radial lines extending from each bladder along its length extend generally toward one or more node groups. Configuration and direction provide an “orientation”. Orientation is established by the direction of sequential pressurization/depressurization of the bladders and the configuration of the bladders on the body. The length of each bladder is optimally determined to move pooled fluids toward a node group. While it is expected that each bladder will be arcuate to some degree, the bladders need not be arcuate along their entire length nor need each bladder be arcuate so long as the bladders are “oriented” toward a node group, as described.  
      Referring generally to  FIGS. 7 and 8 A- 8 E, there is shown a wrap  12  adapted to fit about a body extremity, more particularly a lower body extremity. The wrap  12  generally has several regions (e.g., R 1 -R 4 ), each of which having a plurality of compartments (e.g., C 1  through C n ) distributed there through, with each of the compartments of the plurality of compartments capable of selective pressurization and depressurization so as to manipulate the wrapped body extremity in furtherance of lymphedema treatment.  
      Referring now to  FIG. 7 , the several regions of the wrap  12  preferably include a trunk region (e.g., R 1 ), and several limb regions (e.g., R 2 -R 4 ). The trunk region of the wrap is preferably intended to correspond with (i.e., overlay) the hip or pelvic area of the torso, or more generally, at least a lower portion thereof, wherein the body extremity subject to treatment is a lower body extremity as shown in  FIGS. 8A-8E . Alternately, the trunk region of the wrap may correspond with (i.e., overlay) the shoulder and/or portions of the chest, or more generally, at least an upper portion thereof, wherein the body extremity subject to treatment is an upper body extremity as show in  FIGS. 5 and 6 .  
      The limb regions of the wrap preferably are intended to correspond with (i.e., overlay) the thigh, calf, including the ankle, and foot. Alternately, the limb regions of the wrap may correspond with (i.e., overlay) the biceps, forearm, including the wrist, and hand, wherein the body extremity subject to treatment is an upper body extremity as shown in  FIG. 6A .  
      A wrap suitable for implementing the preferred method of body manipulation may be consistent with that disclosed herein above, namely a wrap having a number of compartments which are sized to receive and hold a number of bladders which are in fluid communication with a pneumatic pump (see  FIGS. 1,3  and  4 ), however, the wrap is not necessarily so limited. For practice of the method of the subject invention, it is preferred that the wrap have several regions (e.g.,. R 1  through R 4 ), and discrete compartments (e.g., C 1  through C n ) distributed throughout each of the several regions R 1  through R 4 . For the sake of convention, R 1  is designated a “proximal” region, whereas R 4  is designated a “distal” region; similarly, in any given region R 1  through R 4 , C 1  is designated a “proximal” compartment, whereas C n  is designated a “distal” compartment. Each of the compartments, C 1  through C n , is capable of selective pressurization and depressurization, as by the pneumatic system describe with respect to  FIG. 1 , or other mechanism for producing such effect, as is known to those of skill in the art. To insure proper therapeutic treatment, the width of the chambers is preferably, but not necessarily, on the order of about 1-2 inches. If the chambers are too wide (i.e., much larger than 3-4 inches), the effectiveness of the therapy received will be degraded. Based upon this preferred criteria, the number of compartments in a given region of the wrap (i.e., “n”) will be variable, based on the extent (i.e., length dimension) of a given region “R.” 
      As previous noted, MLD is highly desirable for the therapeutic results obtainable. MLD massage therapists are taught to treat five upper body sections (i.e., trunk, shoulder, biceps, forearm, and hand), and four sections of the lower body (i.e., trunk, thigh, calf, and foot). The MLD treatment technique applies just enough pressure to massage pooled fluids from larger areas toward specific lymph nodes within the body by mechanically stimulating the lymphatic system to cause contraction of the lymph collectors sufficient to help move the pooled fluids by promoting reabsorption of the pooled fluids within the surrounding tissue. More particularly, the MLD treatment technique is performed in a proximal to distal pattern with respect to the body trunk (e.g., in the four lower body sections as follows: trunk, thigh, calf, and foot), with the hand being applied to the body so as to gently direct the fluid in the proximal direction (i.e., toward the body trunk).  
      The body extremity, once fitted with the wrap, undergoes a preparation step which includes a first pressurization and depressurization sequence of select compartments within select regions of the regions of the wrap. The preparation sequence generally starts in the trunk region and proceeds to a distal limb region of the several limb regions. More particularly, the sequence includes the consecutive pressurization and depressurization of each compartment of the compartments distributed throughout the selected region of the regions of the wrap, beginning with a distal chamber and proceeding to a proximal chamber thereof.  
      Referring now to  FIGS. 8A-8E , the preferred method of the present invention, shown with respect to a lower body extremity, includes preparation (i.e.,  FIGS. 8A-8D ) and drainage ( FIG. 8E ) steps. The compartments C n  through C 1  of the trunk region R 1  are selectively pressurized and depressurized in a direction-toward the body trunk (i.e., a direction distal to proximal as shown by the arrow, or said more simply, from C n  toward C 1 ),  FIG. 8A . The adjacent region, namely the first of the several limb regions (i.e., R 2 ), is likewise selectively pressurized and depressurized in a direction toward the trunk region (i.e., a direction distal to proximal as shown by the arrow, or said more simply, from C n  toward C 1 ),  FIG. 8B . The remaining limb regions, namely the second and third limb regions (i.e., regions R 3  and R 4  respectively), are selectively pressurized and depressurized in a direction toward the trunk region (i.e., a direction distal to proximal as shown by the arrow, or said more simply, from C n  toward C 1 ), as shown in  FIGS. 8C and 8D . In summary, the preferred preparation sequence or first pressurization-depressurization sequence proceeds as follows, R 1 , C n →C 1 ; R 2 , C n →C 1 ; R 3 , C n →C 1 ; and R 4 , C n →C 1 ., with the path from C n  to C 1  being preferably consecutive, but not so limiting. For instance, patient symptoms may dictate that the selective pressurization and depressurization of the compartments of the regions not be uniform, either as to sequence (i.e., pressurization and/or depressurization order), quantum or duration of pressurization, from region to region, or within any given region.  
      After the preparation of the body extremity for receipt of lymph fluid, the body extremity undergoes a drainage step which includes a second pressurization and depressurization sequence of select compartments within select regions of the regions of the wrap such that the lymphatic system is stimulated so as to promote reabsorption of pooled lymph fluid within surrounding tissue. The general sequence or order of pressurization and depressurization is from the distal region (i.e., R 4 ) of the wrap regions sequentially or consecutively to adjacent regions (i.e., R 3  to R 2 ) until reaching the proximal region (i.e., R 1 ). The compartments of each of the regions are consecutively pressurized and depressurized in a direction from the distal chamber to the proximal chamber (i.e., from C n  toward C 1 ). In summary, the preferred drainage sequence or second pressurization/depressurization sequence proceeds as follows, R 4 , C n →C 1 ; R 3 , C n →C 1 ; R 2 , C n →C 1 ; and R 1 , C n →C 1 , with the path from C n  to C 1  being preferably consecutive, but not so limiting. As in the case of preparation, patient symptoms may dictate that the selective pressurization and depressurization of the compartments of the regions not be uniform, either as to sequence (i.e., pressurization and/or depressurization order), quantum or duration of pressurization, from region to region, or within any given region. The sequences of the method are preferably selected, for instance as by programming of a pneumatic controller or the like, on a patient specific basis for optimal therapeutic effect.  
      As previously discussed, MLD is a particularly effective lymphedema treatment methodology, heretofore requiring the specialized skill of a trained clinician, typically one employed at an urban health care facility. The wrap systems and structures of the subject invention impart a systematic low pressure gradient to the edema effected body part or region as previously described with respect to  FIGS. 5-8E . As is readily appreciated, mechanical simulation utilizing a wrap structure is, among other things, critically dependent upon a proper alignment of the wrap about the selected portion of the human form, and securement thereto. Bunching of the applied wrap, or the presence of gaps, apertures, or voids in the surface of the applied wrap are to be avoided, however, overlapping surface portions of the applied wrap are not detrimental to simulation of the technique.  
      It is imperative that the wrap structure be or form a body conforming assembly. Furthermore, and as a practical matter, the wrap structure or assembly is desirably configured such that each of the discrete chambers of the plurality or array of discrete chambers circumscribe a segment of the portion of the human form underlaying the wrap structure (i.e., forms a substantial continuous ring there around, as is especially the case with a limb, as opposed to the torso or portions thereof). A plurality of tabs, or fastening structures more generally, desirably extend from or beyond the array of chambers of the wrap structure in furtherance of conforming specific portions or segments thereof to corresponding portions of the affected body region.  
      As will be subsequently discussed, the wrap structure of the subject invention is characterized in part by discrete, non-uniformly curved chambers capable of selective, systematic, reversible pressurization. The periphery of the wrap structure is further especially configured so as to, alone or in combination with another wrap structure or structures, suitably form select circumscribing compartments which fit (i.e., correspond to) the underlaying body contour. It is the profiled margin (i.e., outer dimensional design) of the wrap structure which contributes to the overall wrap fit, the arcuate configuration of the chambers being essential due to their need to conform to body contours and maintain position with respect to lymphatic flow (i.e., maintain the developed or developing pressure gradient perpendicular to lymphatic flow).  
      As a preliminary matter,  FIG. 9  generally depicts a wrap system applied to an upper limb/torso, the specific wrap structures or elements associated therewith shown in  FIGS. 10-11C , namely an arm wrap ( FIG. 10 ) and a chest wrap ( FIG. 11 ).  FIG. 12  generally depicts a wrap system applied to a lower limb/torso, the specific wrap structures associated therewith shown in  FIGS. 12-20 , namely the calf-foot assembly components of  FIGS. 13A &amp; 13B , and the trunk-thigh assembly components of  FIGS. 14A &amp; 14B .  
      With general reference to  FIGS. 9 &amp; 12 , a wrap system  200  for systematic mechanical lymphatic stimulation generally includes first and second wrap structures or assemblies  202  coupled or joined for operative engagement. Fluid flow is indicated thereon, namely flowing from the edema to the proximal lymph nodes.  
      The first wrap structure or assembly  202  includes a plurality  204  of discrete continuous compartments  206  formed interior of a margin  208  of a composite material panel  210 . As previously detailed, each of the compartments  206  of the array of compartments  204  are adapted for individual pressurization/depressurization in furtherance of MLD simulation. Fastening means  212 , as will be later be detailed with respect to the specific wrap structures, extend from the margin  208  so as to permit linkage of the structures so as to form the system  200 . The second wrap structure  202  is similarly characterized by an array  204  of discrete continuous compartments  206  which are formed integral to a composite material panel  210  and interior of a margin  208  thereof. The margin  208  preferably includes fastening means  212  extending therefrom. The margin of the first wrap structure advantageously has a first configuration  213  (see e.g.,  FIGS. 13A, 14A ) while the margin of said second wrap advantageously has a second configuration  215  (see e.g.,  FIGS. 13B, 14B ), the second configuration  215  being different from the first configuration  213  (e.g., the wrap structures of the assembly or system generally lack symmetry, see the wrap structure pairs of FIGS.  13 A/ 13 B and/or FIGS.  14 A/ 14 B).  
      Referring now generally to the wrap structures of  FIGS. 10, 11 ,  13 A/ 13 B, and/or  14 A/ 14 B, the wrap structures  202  include a composite material panel  210  having a margin  208  and a plurality  204  of discrete tubular chambers  206  formed in the panel  210  so as to be generally bounded by the margin  208  (i.e., the margin, however minimal, surrounds or bounds the array of chambers). Select discrete tubular chambers of the plurality of discrete tubular chambers  204  are irregularly curved (i.e., although some number of the tubular chambers may “nest” together, they do not in their entirety aligningly nest together such that lines tangent to the curve of each chamber are in radial alignment throughout the entire array), more particularly, within the array of discrete chambers  204 , there exists no homogeneity of curvature.  
      Each of the discrete tubular chambers  206  (i.e., flat reversibly inflatable compartments) formed in the composite material panel  210  are generally continuous throughout their length, and preferably, but not necessarily have a uniform or substantially uniform cross-section there along. As will be later detailed, the pneumatically isolated chambers  206  are preferably formed by radio frequency welding of opposingly paired adjacent sheets of material amenable to such procedure. As such, each reversibly expandable compartment  206  so formed may be fairly characterized as having opposingly paired lateral edges  214  (i.e., ends) and opposingly paired longitudinal edges  216  (i.e., the “wall” of the chamber is not continuous, in contradistinction to the bladder  44  of  FIG. 3 , two halves being joined by a weld or other means).  
      Each of the wrap structures of the subject invention requires a flexure (i.e., bending), or more broadly, a manipulation, in furtherance of application to an affected body part. The physical point of manipulation (i.e., a wrap axis)  218  of the wrap structures generally passes through or traverses each of the chambers  206  of the array of chambers  204 .  
      A further feature of the chambers  204  of the array of chambers  206  are pneumatic couplings or stems  220 . As each discrete chamber  206  includes a pneumatic coupling  220 , each discrete chamber  206  is pneumatically isolated, and is therefore independently operable consistent with the previously detailed methodology.  
      To provide a more finished look to the wrap structures, and assist fluid ingress/egress via conduit management, wrap structure covers  222  ( FIGS. 10A, 11C ,  17 , and  20 ) are reversibly affixable to the exterior of the wrap structures  202  so as to overlay the pneumatic couplings  220 . Portions of the cover, more particularly, but not exclusively, opposing edge portions  224 , are equipped with components of a hook and loop fastening system (e.g., hooks)  226  for securing same to portions of the wrap structure  202 . The pneumatic couplings  220  of the wrap structure  202  are securingly received within spaced apart apertures  228  of the cover  222  by the adhesion of the hooks  226  thereof to the exterior surface of the wrap structure  202  in the vicinity of the pneumatic couplings  220 . The opposing free longitudinal edge  230  of the cover  222  is thereafter folded or otherwise manipulated so as to form a conduit receiving crotch, the hooks  226  of this edge  230  being securingly received upon the wrap cover  222  such that a portion of the cover overlays the pneumatic couplings  220 . A free lateral end  232  of the generally elongate cover  222 , delimited by a slit  234 , is configured to be wrapped about the pneumatic lines or conduits exiting the crotch formed by the applied cover so as to form a neat conduit bundle.  
      The wrap structure  202  generally has a periphery or outer limit  236  defined at least in part by the margin  208  of the composite material panel  210 . As previously noted, the wrap structure  202  generally includes fastening means  212  to facilitate the formation of a wrap assembly or wrap system  200  (i.e., the union of two or more wrap structures). Preferably, but not necessarily or exclusively, the margin  208  includes at least a single tab  238 , or single set of tabs. By this construct, the tabs  238  are integral to the wrap structure. The tabs  238  preferably include a component  226  of a hook and loop fastening system so as to quickly and easily fit the structure  202  upon the affected body part, as well as unite the single wrap structure to one or more thereof in furtherance of forming a wrap assembly or system  200 . The tabs  238 , in combination with straps  240 , as the case may be ( FIGS. 11A and 11B ), further insure that a conforming fit is had, the tabs  238  being strategically positioned along the margin  208  of the composite material panel  210  so that bunching thereof is avoided, and the affected body part is in fact overlain by the wrap (i.e., gaps between mating portions of the wrap structures are to be avoided, such omitted coverage being a hindrance to the simulated MLD methodology).  
      Referring now specifically to  FIG. 10 , a left arm wrap structure is shown having compartments designated C 1 -C 8  and D 1 -D 8 , with compartments C 1  and D 8  defining the longitudinal extent of the array of compartments. It is to be understood that although the compartment designations have utility relative to the systematic delivery of pressurized fluid to the wrap structure in furtherance of lymphedema treatment, the adaptation of this or other reference scheme is not, and should not be considered limiting in any way, provisions thereof being a discussion aid in the present context.  
      As shown, compartments C 5 -C 7  are intended to correspond to bicep placement, C 8 -D 4  to forearm placement, and D 5 -D 8  to hand placement. It is to be understood that select chambers may be eliminated (e.g., C 6  and D 2 ) to accommodate a shorter arm length. Generally, the curvature of each of the chambers diminishes proceeding from chamber C 1  (arm pit area) to D 8  (finger tip), more particularly, as the chambers proceed from chamber C 1  to D 8 , their angular orientation with respect to the wrap axis increases (i.e., the chambers extend in opposing directions from the wrap axis, the angle associated therewith decreasing from C 1  to D 8 ) . Finally, each longitudinal region of the warp structure includes dedicated fastening means  212 , with further fastening means incorporated into the margin  208  adjacent chamber C 1 .  
      Referring now specifically to  FIG. 11 , a chest wrap structure is shown having compartments designated B 1 -B 4 . Each of the compartments B 1 -B 4  pass through the wrap axis  218 , a point intended to overlay the top of the shoulder, thereby dividing the wrap structure into chest and back portions. The compartments overlay the affected body portion such that compartment B 4  is closest to the sternum (i.e., the “open” end of the composite material panel laterally extending away from the sternum). Fastening means  212  is provided integral to margin  208  adjacent the pneumatic couplers  220  (for linkage with and to the arm wrap structure of  FIG. 10  so as to produce the integrated assembly of  FIG. 9 ), in addition to those positioned at the margin  208  adjacent the “bends” of compartment B 4  (for engagement with the straps of  FIGS. 11A &amp; 11B  so as to secure this structure to the torso).  
      Referring now specifically to  FIGS. 15 &amp; 16 , the structures of a left calf-foot wrap assembly are shown, each having compartments designated C 1 -C 8  and D 1 -D 8 , which when then two structures are integrated, form a substantially continuous, limb circumscribing array of chambers. The margin  208  of the composite material panel  210  of this structure generally tapers from top (C 1 ) to bottom (D 8 ) and includes a longitudinal edge having a characteristic irregularity (i.e., protrusion) beginning at the chamber designated D 1 . The configuration of the longitudinal edges greatly enhances the “wrap around” fit of the structure so as to permit the chambers to be cylindrical about (i.e., encircle as a tubular or tube-like element) the limb, and to maintain the chambers in a substantially perpendicular alignment or orientation with respect to lymphatic flow.  
      Referring now specifically to  FIG. 18 &amp; 19 , the structures of a torso-thigh wrap assembly are shown having compartments designated A 1 -A 8  and B 1 -B 8 . The compartment array  204  includes an elongate trunk portion (A 1 -A 6 ) from which depends a thigh portion (A 7 -B 8 ). Each of the structures is characterized by a recess or indentation in the margin  208  of the composite material panel  210  in the vicinity of chamber A 6 .  
      The composite material panel of the subject wrap structures greatly enhances the body conforming quality of the wrap structure. Functionally, the composite material panel of the wrap structure is required to be reversibly and selectively expandable (i.e., the panel has a variable non-constant thickness throughout its areal extent during MLD simulation), and be conforming to portions of the human form (i.e., have an inherent reversible stretch quality or character in addition to having a fastening system which permits the wrap to be fit or worn in the first instance). An especially advantageous construct for the composite material panel for the subject wrap structures is illustrated in  FIG. 21 .  
      With reference to  FIG. 21 , the composite material panel  210  of the subject wrap structure generally includes opposingly paired exterior sheets  250  within which is contained, or between which is enclosed, opposing paired adjacent interior sheets  252 . As will later be discussed, the sheets  250 ,  252  are layered so as to overlay each other, and are thereafter selectively integrated, as by radio frequency welding, so as to form an array of discrete chambers therein, more particularly, spaced apart unions of the first exterior sheet  250   a  with or to the first interior sheet  252   a  with or to the second interior sheet  252   b  with or to the second exterior sheet  250   b  are formed.  
      The opposingly paired exterior sheets  250  preferably comprise a two layer laminate. Fabric  254  having a multidirectional stretch is united with a resilient foam layer  256 , as for instance by flame lamination. It is particularly advantageous that the fabric be breathable, generally skin “friendly,” and have a preferred direction of stretch or elongation. That is to say, although the fabric  254  has a four way stretch, it is capable of preferential elongation or axial stretch. The fabric  254  of the exterior layer  250  preferably has a maximum stretch direction at about a 45° angle from a machine direction (i.e., the fabric width or “fill” designation, as opposed to the “warp” of the fabric) of or for the fabric. One know laminate exhibiting the desired characteristics is that offered by American Foam &amp; Fabric of Greenville, S.C., namely a 100% nylon Alpine headliner VL-1879 having a sheet of a S1300B open cell polyurethane foam laminated thereto. The foam thickness is preferably 0.135 inches, the exterior sheet or laminate having a finished thickness of about 0.125 inches. To most closely mimic MLD utilizing the subject wrap structures, the array of pneumatic chambers, or the margin more generally, of the structure is to be “laid out” (i.e., oriented) with respect the fabric  254  of the exterior sheet  250  as shown in the figures, namely  FIGS. 10, 11 ,  15 ,  16 ,  18  &amp;  19  (i.e., the fabric width is substantially orthogonal to the wrap axis of the wrap structure).  
      The opposingly paired adjacent interior sheets  252  form or define the fluid retaining portion of the chambers. The interior sheets  252  preferably comprise a 5 mil thick 85A durometer polyether (i.e., polyurethane). Subsequent to forming the exterior laminate sheets  250 , the four sheets are introduced into the production machine and RF welded to form the wrap and chamber welds simultaneously.  
      While a preferred embodiment of the present invention has been described, it should be understood that various changes, adaptations and modifications may be made therein without departing from the spirit of the invention. Changes may be made in details, particularly in matters of shape, size, material, and arrangement of parts without exceeding the scope of the invention. Accordingly, the scope of the invention is as defined in the language of the appended claims.