Patent Publication Number: US-2022226495-A1

Title: Bivalent, bispecific binding proteins for prevention or treatment of hiv infection

Description:
CROSS REFERENCES TO RELATED APPLICATIONS 
     This application is a continuation of U.S. patent application Ser. No. 16/659,426, filed Oct. 21, 2019, which is a continuation of U.S. patent application Ser. No. 15/770,471, which adopts the international filing date of Oct. 24, 2016, which is a National Phase application under 35 U.S.C. § 371 of International Application No. PCT/US2016/058540, filed Oct. 24, 2016, which claims the priority benefit of U.S. Provisional Application No. 62/246,113, filed Oct. 25, 2015, EP Application No. EP16305211.1, filed Feb. 24, 2016, U.S. Provisional Application No. 62/322,029, filed Apr. 13, 2016, and U.S. Provisional Application No. 62/331,169, filed May 3, 2016, which are incorporated herein by reference in their entirety. 
    
    
     This invention was created in the performance of a Cooperative Research and Development Agreement (NIAID #2014-0038) with the National Institutes of Health, an agency of the Department of Health and Human Services. The Government of the United States has certain rights in this invention. 
    
    
     SUBMISSION OF SEQUENCE LISTING ON ASCII TEXT FILE 
     The content of the following submission on ASCII text file is incorporated herein by reference in its entirety: a computer readable form (CRF) of the Sequence Listing (file name: 183952027002SEQLIST.txt, date recorded: Aug. 13, 2021, size: 1,089 KB). 
     FIELD OF THE INVENTION 
     The disclosure relates to trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also relates to methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins for treating and/or preventing HIV/AIDS. 
     BACKGROUND 
     One of the challenges in treating HIV/AIDS with neutralizing antibodies is potential breakthrough infection due to the high mutation rate of HIV-1 viruses. Additionally, virological events in the early weeks following HIV-1 transmission set the stage for lifelong chronic infection that remains incurable with currently available combination antiretroviral therapy (cART). This is due, at least in part, to the early establishment of viral reservoirs, including latently infected cells, which persist despite cART, leading to recrudescent infection when treatment is interrupted. Newly discovered anti-HIV-1 neutralizing antibodies with improved breadth and potency may provide more options for HIV/AIDS treatment and prevention; however, breakthrough infection remains a major issue in the field. 
     BRIEF SUMMARY 
     In one embodiment, the disclosure provides a binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II]
 
     a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1   [III];
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV];
 
     wherein
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is an immunoglobulin C H1  heavy chain constant domain; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     In some embodiments, the second polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. In some embodiments, the third polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains; wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     In one embodiment, the disclosure provides a binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1 -hinge-C H2 -C H3   [II]
 
     and a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1 -hinge-C H2 -C H3   [III]
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is an immunoglobulin C H1  heavy chain constant domain;
 
C H2  is an immunoglobulin C H2  heavy chain constant domain;
 
C H3  is an immunoglobulin C H3  heavy chain constant domain; hinge is an immunoglobulin hinge region connecting the C H1  and C H2  domains; and
 
L 1 , L 2 , L 3  and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     In some embodiments, the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. In some embodiments, the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. In some embodiments, the C H3  domains of the second and the third polypeptide chains both comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     In some embodiments, the one or more HIV target protein is selected from the group consisting of glycoprotein 120, glycoprotein 41 and glycoprotein 160. In some embodiments, the binding protein is trispecific and capable of specifically binding three different epitopes on a single HIV target protein. In some embodiments, the binding protein is trispecific and capable of specifically binding two different epitopes on a first HIV target protein, and one epitope on a second HIV target protein, wherein the first and second HIV target proteins are different. In some embodiments, the binding protein is trispecific and capable of specifically binding three different antigen targets. In some embodiments, the binding protein is capable of inhibiting the function of one or more HIV target proteins. In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; or a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively. In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. In some embodiments, V L1  comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. In some embodiments, V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; or a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively. In some embodiments, V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. In some embodiments, V L2  comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. In some embodiments, V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; or a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively. In some embodiments, V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. In some embodiments, V L3  comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. In some embodiments, V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; or a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively. In some embodiments, V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. In some embodiments, V H1  comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. In some embodiments, V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; or a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively. In some embodiments, V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. In some embodiments, V H2  comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. In some embodiments, V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; or a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively. In some embodiments, V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. In some embodiments, V H3  comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. In some embodiments, V L1  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 500, a CDR-L2 comprising the sequence of SEQ ID NO: 501, and a CDR-L3 comprising the sequence of SEQ ID NO: 274; V L2  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 275, a CDR-L2 comprising the sequence of SEQ ID NO: 276, and a CDR-L3 comprising the sequence of SEQ ID NO: 277; V L3  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 266, a CDR-L2 comprising the sequence of SEQ ID NO: 267, and a CDR-L3 comprising the sequence of SEQ ID NO: 268; V H1  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 254, a CDR-H2 comprising the sequence of SEQ ID NO: 255, and a CDR-H3 comprising the sequence of SEQ ID NO: 256; V H2  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 257, a CDR-H2 comprising the sequence of SEQ ID NO: 258, and a CDR-H3 comprising the sequence of SEQ ID NO: 259; and V H3  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 248, a CDR-H2 comprising the sequence of SEQ ID NO: 497, and a CDR-H3 comprising the sequence of SEQ ID NO: 250. In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 518; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 519; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 512; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 504; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 506; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 502. In some embodiments, V L1  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 518; V L2  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 519; V L3  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 512; V H1  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 504; V H2  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 506; and V H3  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 502. In some embodiments, V L1  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 500, a CDR-L2 comprising the sequence of SEQ ID NO: 501, and a CDR-L3 comprising the sequence of SEQ ID NO: 274; V L2  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 275, a CDR-L2 comprising the sequence of SEQ ID NO: 276, and a CDR-L3 comprising the sequence of SEQ ID NO: 277; V L3  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 269, a CDR-L2 comprising the sequence of SEQ ID NO: 270, and a CDR-L3 comprising the sequence of SEQ ID NO: 271; V H1  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 254, a CDR-H2 comprising the sequence of SEQ ID NO: 255, and a CDR-H3 comprising the sequence of SEQ ID NO: 256; V H2  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 257, a CDR-H2 comprising the sequence of SEQ ID NO: 258, and a CDR-H3 comprising the sequence of SEQ ID NO: 259; and V H3  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 251, a CDR-H2 comprising the sequence of SEQ ID NO: 252, and a CDR-H3 comprising the sequence of SEQ ID NO: 253. In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 518; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 519; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 513; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 504; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 506; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 503. In some embodiments, V L1  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 518; V L2  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 519; V L3  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 513; V H1  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 504; V H2  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 506; and V H3  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 503. In some embodiments, V L1  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 275, a CDR-L2 comprising the sequence of SEQ ID NO: 276, and a CDR-L3 comprising the sequence of SEQ ID NO: 277; V L2  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 500, a CDR-L2 comprising the sequence of SEQ ID NO: 501, and a CDR-L3 comprising the sequence of SEQ ID NO: 274; V L3  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 269, a CDR-L2 comprising the sequence of SEQ ID NO: 270, and a CDR-L3 comprising the sequence of SEQ ID NO: 271; V H1  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 257, a CDR-H2 comprising the sequence of SEQ ID NO: 258, and a CDR-H3 comprising the sequence of SEQ ID NO: 259; V H2  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 254, a CDR-H2 comprising the sequence of SEQ ID NO: 255, and a CDR-H3 comprising the sequence of SEQ ID NO: 256; and V H3  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 251, a CDR-H2 comprising the sequence of SEQ ID NO: 252, and a CDR-H3 comprising the sequence of SEQ ID NO: 253. In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 519; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 518; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 513; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 506; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 504; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 503. In some embodiments, V L1  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 519; V L2  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 518; V L3  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 513; V H1  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 506; V H2  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 504; and V H3  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 503. In some embodiments, at least one of L 1 , L 2 , L 3 , or L 4  is independently 0 amino acids in length. In some embodiments, L 1 , L 2 , L 3 , or L 4  are each independently at least one amino acid in length. In some embodiments, L 1  comprises Asp-Lys-Thr-His-Thr (SEQ ID NO: 525). 
     In one embodiment, the disclosure provides a binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II]
 
     and a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1   [III]
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair;
 
wherein:
 
     (a) V L1 , V L2  and V L3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 2, 4, 10, 12, 18, 20, 26, 28, 34, 36, 42, 44, 50, 52, 58, 60, 66, 68, 74, 76, 82, 84, 90, 92, 98, 100, 106, 108, 114, 116, 122, 124, 130, 132, 138, 140, 146, 148, 154, 156, 162, 164, 170, 172, 178, 180, 186, 188, 194, 196, 202, 204, 210,212, 218, 220, 226, 228, 233, 235, 241, 243; or 
     (b) V L1 , V L2  and V L3  each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs:266-283; and 
     wherein: 
     (a) V H1 , V H2 , and V H3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 1, 3, 9, 11, 17, 10, 25, 27, 33, 35, 41, 43, 49, 51, 57, 59, 65, 67, 73, 75, 81, 83, 89, 91, 97, 99, 105, 107, 113, 115, 121, 123, 129, 131, 137, 139, 145, 147, 153, 155, 161, 163, 169, 171, 177, 179, 185, 187, 193, 195, 201, 203, 209, 211, 217, 219, 225, 227, 232, 234, 240, 242; or 
     (b) V H1 , V H2 , and V H3  each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-265. 
     In some embodiments, the second polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. In some embodiments, the third polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains; wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     In one embodiment, the disclosure provides a binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1 -hinge-C H2 -C H3   [II]
 
     and a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1 -hinge-C H2 -C H3   [III]
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain;
 
C H2  is an immunoglobulin C H2  heavy chain constant domain;
 
C H3  is an immunoglobulin C H3  heavy chain constant domain; hinge is an immunoglobulin hinge region connecting the C H1  and C H2  domains; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair;
 
wherein:
 
     (a) V L1 , V L2  and V L3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 2, 4, 10, 12, 18, 20, 26, 28, 34, 36, 42, 44, 50, 52, 58, 60, 66, 68, 74, 76, 82, 84, 90, 92, 98, 100, 106, 108, 114, 116, 122, 124, 130, 132, 138, 140, 146, 148, 154, 156, 162, 164, 170, 172, 178, 180, 186, 188, 194, 196, 202, 204, 210,212, 218, 220, 226, 228, 233, 235, 241, 243; or 
     (b) V L1 , V L2  and V L3  each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs:266-283; and 
     wherein: 
     (a) V H1 , V H2 , and V H3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 1, 3, 9, 11, 17, 10, 25, 27, 33, 35, 41, 43, 49, 51, 57, 59, 65, 67, 73, 75, 81, 83, 89, 91, 97, 99, 105, 107, 113, 115, 121, 123, 129, 131, 137, 139, 145, 147, 153, 155, 161, 163, 169, 171, 177, 179, 185, 187, 193, 195, 201, 203, 209, 211, 217, 219, 225, 227, 232, 234, 240, 242; or 
     (b) V H1 , V H2 , and V H3  each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-265. 
     In some embodiments, the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. In some embodiments, the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. In some embodiments, the C H3  domains of the second and the third polypeptide chains both comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     In some embodiments, at least one of L 1 , L 2 , L 3 , or L 4  is independently 0 amino acids in length. In some embodiments, L 1 , L 2 , L 3 , or L 4  are each independently at least one amino acid in length. In some embodiments, L 1  comprises Asp-Lys-Thr-His-Thr (SEQ ID NO: 525). 
     In one embodiment, the disclosure provides a trispecific and/or trivalent binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind three different HIV target proteins, wherein a first polypeptide chain has a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain has a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II]
 
     and a third polypeptide chain has a structure represented by the formula: 
       V H3 -C H1   [III]
 
     and a fourth polypeptide chain has a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein: 
     V L1  is a first immunoglobulin light chain variable domain; 
     V L2  is a second immunoglobulin light chain variable domain; 
     V L3  is a third immunoglobulin light chain variable domain; 
     V H1  is a first immunoglobulin heavy chain variable domain; 
     V H2  is a second immunoglobulin heavy chain variable domain; 
     V H3  is a third immunoglobulin heavy chain variable domain; 
     C L  is an immunoglobulin light chain constant domain; 
     C H1  is the immunoglobulin C H1  heavy chain constant domain; and 
     L 1 , L 2 , L 3  and L 4  are amino acid linkers; 
     and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair. 
     In one embodiment, the disclosure provides a binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain has a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain has a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II]
 
     and a third polypeptide chain has a structure represented by the formula: 
       V H3 -C H1   [III]
 
     and a fourth polypeptide chain has a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein: 
     V L1  is a first immunoglobulin light chain variable domain; 
     V L2  is a second immunoglobulin light chain variable domain; 
     V L3  is a third immunoglobulin light chain variable domain; 
     V H1  is a first immunoglobulin heavy chain variable domain; 
     V H2  is a second immunoglobulin heavy chain variable domain; 
     V H3  is a third immunoglobulin heavy chain variable domain; 
     C L  is an immunoglobulin light chain constant domain; 
     C H1  is the immunoglobulin C H1  heavy chain constant domain; and 
     L 1 , L 2 , L 3 , and L 4  are amino acid linkers; 
     wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair; 
     wherein: 
     (a) V L1 , V L2  and V L3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 2, 4, 10, 12, 18, 20, 26, 28, 34, 36, 42, 44, 50, 52, 58, 60, 66, 68, 74, 76, 82, 84, 90, 92, 98, 100, 106, 108, 114, 116, 122, 124, 130, 132, 138, 140, 146, 148, 154, 156, 162, 164, 170, 172, 178, 180, 186, 188, 194, 196, 202, 204, 210,212, 218, 220, 226, 228, 233, 235, 241, 243; or 
     (b) V L1 , V L2  and V L3  each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs:266-283; and 
     wherein: 
     (a) V H1 , V H2 , and V H3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 1, 3, 9, 11, 17, 10, 25, 27, 33, 35, 41, 43, 49, 51, 57, 59, 65, 67, 73, 75, 81, 83, 89, 91, 97, 99, 105, 107, 113, 115, 121, 123, 129, 131, 137, 139, 145, 147, 153, 155, 161, 163, 169, 171, 177, 179, 185, 187, 193, 195, 201, 203, 209, 211, 217, 219, 225, 227, 232, 234, 240, 242; or
 
(b) V H1 , V H2 , and V H3  each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-265.
 
     In another embodiment, the disclosure provides a binding protein comprising a first polypeptide chain, a second polypeptide chain, a third polypeptide chain and a fourth polypeptide chain wherein: 
     (a) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 4 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 4; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 3; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 1; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 2; 
     (b) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 12 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 12; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 11 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 11; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 9 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 9; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 10 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 10; 
     (c) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 20 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 20; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 19 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 19; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 17 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 17; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 18 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 18; 
     (d) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 28 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 28; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 27 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 27; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 25 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 25; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 26 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 26; 
     (e) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 36; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 35 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 35; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 33 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 33; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 34 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 34; 
     (f) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 44 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 44; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 43 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 43; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 41 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 41; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 42 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 42; 
     (g) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 52 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 52; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 51 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 51; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 49 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 49; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 50 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 50; 
     (h) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 60 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 60; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 59 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 59; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 57 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 57; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 58 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 58; 
     (i) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 68 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 68; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 67 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 67; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 65 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 65; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 66 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 66; 
     (j) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 76 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 76; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 75 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 75; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 73 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 73; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 74 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 74; 
     (k) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 84 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 84; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 83 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 83; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 81 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 81; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 82 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 82; 
     (l) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 92 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:92; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 91 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 91; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 89 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 89; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 90 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 90; 
     (m) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 100 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 100; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 99 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 99; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 97 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 97; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 98 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 98; 
     (n) the first polypeptide comprises the amino acid sequence of SEQ ID NO: 108 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 108; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 107 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 107; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 105 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 105; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 106 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 106; 
     (o) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 116 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 116; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 115 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 115; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 113 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 113; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 114 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 114; 
     (p) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 124 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 124; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 123 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 123; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 121 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 121; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 122 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 122; 
     (q) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 132 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 132; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 131 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 131; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 129 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 129; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 130 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 130; 
     (r) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 140 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 140; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 139 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 139; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 137 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 137; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 138 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 138; 
     (s) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 148 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 148; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 147 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 147; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 145 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 145; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 146 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 146; 
     (t) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 156 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 156; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 155 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 155; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 153 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 153; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 154 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 154; 
     (u) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 164 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 164; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 163 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 163; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 161 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 161; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 162 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 162; 
     (v) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 172 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 172; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 171 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 171; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 169 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 169; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 170 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 170; 
     (w) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 180 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 180; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 179 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 179; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 177 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 177; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 178 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 178; 
     (x) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 188 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 188; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 187 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 187; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 185 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 185; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 186 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 186; 
     (y) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 196 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 196; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 195 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 195; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 193 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 193; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 194 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 194; 
     (z) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 204 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 204; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 203 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 203; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 201 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 201; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 202 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 202; 
     (aa) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 212 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 212; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 211 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 211; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 209 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 209; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 210 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 210; 
     (bb) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 220 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 220; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 219 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 219; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 217 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 217; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 218 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 218; 
     (cc) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 228 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 228; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 227 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 227; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 225 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 225; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 226 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 226; 
     (dd) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 235 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 235; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 234 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 234; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 232 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 232; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 233 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 233; or 
     (ee) first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 243 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 243; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 242 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 242; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 240 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 240; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 241 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 241. 
     In one embodiment, the disclosure provides a binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins and one or more T cell target proteins, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I];
 
     a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II];
 
     a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1   [III];
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV];
 
     wherein
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     In some embodiments, the second polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. In some embodiments, the third polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains; wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     In one embodiment, the disclosure provides a binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins and one or more T cell target proteins, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I];
 
     a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1 -hinge-C H2 -C H3   [II];
 
     a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1 -hinge-C H2 -C H3   [III];
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV];
 
     wherein
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain;
 
C H2  is an immunoglobulin C H2  heavy chain constant domain;
 
C H3  is an immunoglobulin C H3  heavy chain constant domain; hinge is an immunoglobulin hinge region connecting the C H1  and C H2  domains; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     In some embodiments, the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. In some embodiments, the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. In some embodiments, the C H3  domains of the second and the third polypeptide chains both comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     In some embodiments, the one or more HIV target proteins are selected from the group consisting of glycoprotein 120, glycoprotein 41 and glycoprotein 160. In some embodiments, the one or more T cell target proteins are CD3 or CD28. In some embodiments, the binding protein is trispecific and capable of specifically binding an HIV target protein and two different epitopes on a single T cell target protein. In some embodiments, the binding protein is trispecific and capable of specifically binding an HIV target protein and two different T cell target proteins. In some embodiments, the binding protein is trispecific and capable of specifically binding a T cell target protein and two different epitopes on a single HIV target protein. In some embodiments, the binding protein is trispecific and capable of specifically binding a T cell target protein and two different HIV target proteins. In some embodiments, the first and second polypeptide chains form two antigen binding sites that specifically target two T cell target proteins, and the third and fourth polypeptide chains form an antigen binding site that specifically binds an HIV target protein. In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively; a sequence as set forth in SEQ ID NOs: 488, 489, and 490, respectively; a sequence as set forth in SEQ ID NOs: 491, 492, and 493, respectively; or a sequence as set forth in SEQ ID NOs: 494, 495, and 496, respectively. In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. In some embodiments, V L1  comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. In some embodiments, V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively; a sequence as set forth in SEQ ID NOs: 488, 489, and 490, respectively; a sequence as set forth in SEQ ID NOs: 491, 492, and 493, respectively; or a sequence as set forth in SEQ ID NOs: 494, 495, and 496, respectively. In some embodiments, V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. In some embodiments, V L2  comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. In some embodiments, V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively; a sequence as set forth in SEQ ID NOs: 488, 489, and 490, respectively; a sequence as set forth in SEQ ID NOs: 491, 492, and 493, respectively; or a sequence as set forth in SEQ ID NOs: 494, 495, and 496, respectively. In some embodiments, V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. In some embodiments, V L3  comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. In some embodiments, V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively; a sequence as set forth in SEQ ID NOs: 479, 480, and 481, respectively; a sequence as set forth in SEQ ID NOs: 482, 483, and 484, respectively; or a sequence as set forth in SEQ ID NOs: 485, 486, and 487, respectively. In some embodiments, V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. In some embodiments, V H1  comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. In some embodiments, V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively; a sequence as set forth in SEQ ID NOs: 479, 480, and 481, respectively; a sequence as set forth in SEQ ID NOs: 482, 483, and 484, respectively; or a sequence as set forth in SEQ ID NOs: 485, 486, and 487, respectively. In some embodiments, V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. In some embodiments, V H2  comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. In some embodiments, V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively; a sequence as set forth in SEQ ID NOs: 479, 480, and 481, respectively; a sequence as set forth in SEQ ID NOs: 482, 483, and 484, respectively; or a sequence as set forth in SEQ ID NOs: 485, 486, and 487, respectively. In some embodiments, V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. In some embodiments, V H3  comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. In some embodiments, V L1  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 488, a CDR-L2 comprising the sequence of SEQ ID NO: 489, and a CDR-L3 comprising the sequence of SEQ ID NO: 490; V L2  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 494, a CDR-L2 comprising the sequence of SEQ ID NO: 495, and a CDR-L3 comprising the sequence of SEQ ID NO: 496; V L3  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 269, a CDR-L2 comprising the sequence of SEQ ID NO: 270, and a CDR-L3 comprising the sequence of SEQ ID NO: 271; V H1  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 479, a CDR-H2 comprising the sequence of SEQ ID NO: 480, and a CDR-H3 comprising the sequence of SEQ ID NO: 481; V H2  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 485, a CDR-H2 comprising the sequence of SEQ ID NO: 486, and a CDR-H3 comprising the sequence of SEQ ID NO: 487; and V H3  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 251, a CDR-H2 comprising the sequence of SEQ ID NO: 252, and a CDR-H3 comprising the sequence of SEQ ID NO: 253. In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 522; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 524; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 513; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 509; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 511; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 503. In some embodiments, V L1  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 522; V L2  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 524; V L3  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 513; V H1  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 509; V H2  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 511; and V H3  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 503. In some embodiments, V L1  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 494, a CDR-L2 comprising the sequence of SEQ ID NO: 495, and a CDR-L3 comprising the sequence of SEQ ID NO: 496; V L2  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 488, a CDR-L2 comprising the sequence of SEQ ID NO: 489, and a CDR-L3 comprising the sequence of SEQ ID NO: 490; V L3  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 269, a CDR-L2 comprising the sequence of SEQ ID NO: 270, and a CDR-L3 comprising the sequence of SEQ ID NO: 271; V H1  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 485, a CDR-H2 comprising the sequence of SEQ ID NO: 486, and a CDR-H3 comprising the sequence of SEQ ID NO: 487; V H2  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 479, a CDR-H2 comprising the sequence of SEQ ID NO: 480, and a CDR-H3 comprising the sequence of SEQ ID NO: 481; and V H3  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 251, a CDR-H2 comprising the sequence of SEQ ID NO: 252, and a CDR-H3 comprising the sequence of SEQ ID NO: 253. In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 524; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 522; 
     V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 513; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 511; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 509; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 503. In some embodiments, V L1  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 524; V L2  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 522; V L3  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 513; V H1  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 511; V H2  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 509; and V H3  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 503. In some embodiments, at least one of L 1 , L 2 , L 3 , or L 4  is independently 0 amino acids in length. In some embodiments, L 1 , L 2 , L 3 , or L 4  are each independently at least one amino acid in length. In some embodiments, L 1  is Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299). 
     In one embodiment, the disclosure provides a binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II]
 
     and a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1   [III]
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair;
 
wherein:
 
     (a) V L1 , V L2  and V L3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 303, 305, 311, 313, 319, 321, 327, 329, 335, 337, 343, 345, 351, 353, 359, 361, 367, 369, 375, 377, 383, 385, 391, 393, 399, 401, 407, 409, 415, 417, 423, 425, 431, 433, 439, 441, 447, 449, 455, 457, 463, 465, 471, 473; or 
     (b) V L1 , V L2  and V L3  each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 266-271, 275-277, 488-496; and 
     wherein: 
     (a) V H1 , V H2 , and V H3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 302, 304, 310, 312, 318, 320, 326, 328, 334, 336, 342, 344, 350, 352, 358, 360, 366, 368, 374, 376, 382, 384, 390, 392, 398, 400, 406, 408, 414, 416, 422, 424, 430, 432, 438, 440, 446, 448, 454, 456, 462, 464, 470, 472; or 
     (b) V H1 , V H2 , and V H3  each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-253, 257-259, 479-487. 
     In some embodiments, the second polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. In some embodiments, the third polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains; wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     In one embodiment, the disclosure provides a binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1 -hinge-C H2 -C H3   [II]
 
     and a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1 -hinge-C H2 -C H3   [III]
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain;
 
C H2  is an immunoglobulin C H2  heavy chain constant domain;
 
C H3  is an immunoglobulin C H3  heavy chain constant domain; hinge is an immunoglobulin hinge region connecting the C H1  and C H2  domains; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair;
 
wherein:
 
     (a) V L1 , V L2  and V L3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 303, 305, 311, 313, 319, 321, 327, 329, 335, 337, 343, 345, 351, 353, 359, 361, 367, 369, 375, 377, 383, 385, 391, 393, 399, 401, 407, 409, 415, 417, 423, 425, 431, 433, 439, 441, 447, 449, 455, 457, 463, 465, 471, 473; or 
     (b) V L1 , V L2  and V L3  each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 266-271, 275-277, 488-496; and 
     wherein: 
     (a) V H1 , V H2 , and V H3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 302, 304, 310, 312, 318, 320, 326, 328, 334, 336, 342, 344, 350, 352, 358, 360, 366, 368, 374, 376, 382, 384, 390, 392, 398, 400, 406, 408, 414, 416, 422, 424, 430, 432, 438, 440, 446, 448, 454, 456, 462, 464, 470, 472; or 
     (b) V H1 , V H2 , and V H3  each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-253, 257-259, 479-487. 
     In some embodiments, the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. In some embodiments, the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. In some embodiments, the C H3  domains of the second and the third polypeptide chains both comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     In some embodiments, at least one of L 1 , L 2 , L 3 , or L 4  is independently 0 amino acids in length. In some embodiments, L 1 , L 2 , L 3 , or L 4  are each independently at least one amino acid in length. In some embodiments, L 1  is Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299). 
     In one embodiment, the disclosure provides a binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain has a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain has a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II]
 
     and a third polypeptide chain has a structure represented by the formula: 
       V H3 -C H1   [III]
 
     and a fourth polypeptide chain has a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein: 
     V L1  is a first immunoglobulin light chain variable domain; 
     V L2  is a second immunoglobulin light chain variable domain; 
     V L3  is a third immunoglobulin light chain variable domain; 
     V H1  is a first immunoglobulin heavy chain variable domain; 
     V H2  is a second immunoglobulin heavy chain variable domain; 
     V H3  is a third immunoglobulin heavy chain variable domain; 
     C L  is an immunoglobulin light chain constant domain; 
     C H1  is the immunoglobulin C H1  heavy chain constant domain; and 
     L 1 , L 2 , L 3 , and L 4  are amino acid linkers; 
     wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair; 
     wherein: 
     (a) V L1 , V L2  and V L3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 303, 305, 311, 313, 319, 321, 327, 329, 335, 337, 343, 345, 351, 353, 359, 361, 367, 369, 375, 377, 383, 385, 391, 393, 399, 401, 407, 409, 415, 417, 423, 425, 431, 433, 439, 441, 447, 449, 455, 457, 463, 465, 471, 473; or 
     (b) V L1 , V L2  and V L3  each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 266-271, 275-277, 488-496; and 
     wherein: 
     (a) V H1 , V H2 , and V H3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 302, 304, 310, 312, 318, 320, 326, 328, 334, 336, 342, 344, 350, 352, 358, 360, 366, 368, 374, 376, 382, 384, 390, 392, 398, 400, 406, 408, 414, 416, 422, 424, 430, 432, 438, 440, 446, 448, 454, 456, 462, 464, 470, 472; or 
     (b) V H1 , V H2 , and V H3  each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-253, 257-259, 479-487. 
     In another embodiment, the disclosure provides a binding protein comprising a first polypeptide chain, a second polypeptide chain, a third polypeptide chain and a fourth polypeptide chain wherein: 
     (a) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 305 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 305; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 304 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 304; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 302 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 302; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 303 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 303; 
     (b) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 313 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 313; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 312 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 312; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 310 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 310; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 311 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 311; 
     (c) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 321 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 321; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 320 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 320; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 318 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 318; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 319 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 319; 
     (d) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 329 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 329; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 328 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 328; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 326 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 326; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 327 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 327; 
     (e) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 337 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 337; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 336 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 336; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 334 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 334; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 335 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 335; 
     (f) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 345 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 345; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 344 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 344; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 342 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 342; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 343 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 343; 
     (g) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 353 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 353; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 352 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:352; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 350 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 350; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 351 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 351; 
     (h) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 361 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 361; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 360 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 360; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 358 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 358; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 359 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 359; 
     (i) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 369 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 369; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 368 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 368; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 366 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 366; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 367 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 367; 
     (j) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 377 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 377; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 376 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 376; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 374 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 374; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 375 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 375; 
     (k) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 385 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 385; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 384 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 384; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 382 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 382; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 383 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 383; 
     (l) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 393 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 393; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 392 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 392; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 390 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 390; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 391 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 391; 
     (m) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 401 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 401; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 400 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 400; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 398 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 398; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 399 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 399; 
     (n) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 409 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 409; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 408 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 408; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 406 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 406; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 407 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 407; 
     (p) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 417 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 417; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 416 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 416; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 414 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 414; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 415 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 415; 
     (q) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 425 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 425; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 424 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 424; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 422 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 422; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 423 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 423; 
     (r) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 433 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:433; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 432 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 432; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 430 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 430; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 431 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 431; 
     (s) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 441 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 441; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 440 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 440; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 438 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 438; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 439 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 439; 
     (t) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 449 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 449; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 448 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 448; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 446 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 446; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 447 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 447; 
     (u) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 457 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 457; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 456 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 456; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 454 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 454; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 455 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 455; 
     (v) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 465 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 465; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 464 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 464; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 462 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 462; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 463 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 463; or 
     (w) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 473 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 473; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 472 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 472; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 470 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 470; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 471 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 471. 
     In one embodiment, the disclosure provides an isolated nucleic acid molecule comprising a nucleotide sequence encoding the binding protein according to any of the above embodiments. In one embodiment, the disclosure provides an expression vector comprising the nucleic acid molecule according to any of the above embodiments. In one embodiment, the disclosure provides an isolated host cell comprising the nucleic acid molecule according to any of the above embodiments. In one embodiment, the disclosure provides an isolated host cell comprising the expression vector according to any of the above embodiments. In some embodiments, the isolated host cell is a mammalian cell or an insect cell. In one embodiment, the disclosure provides a vector system comprising one or more vectors encoding a first, second, third, and fourth polypeptide chain of a binding protein according to any of the above embodiments. In some embodiments, the vector system comprises a first vector encoding the first polypeptide chain of the binding protein, a second vector encoding the second polypeptide chain of the binding protein, a third vector encoding the third polypeptide chain of the binding protein, and a fourth vector encoding the fourth polypeptide chain of the binding protein. In some embodiments, the vector system comprises a first vector encoding the first and second polypeptide chains of the binding protein, and a second vector encoding the third and fourth polypeptide chains of the binding protein. In some embodiments, the one or more vectors are expression vectors. In one embodiment, the disclosure provides an isolated host cell comprising the vector system according to any of the above embodiments. In some embodiments, the isolated host cell is a mammalian cell or an insect cell. In one embodiment, the disclosure provides a method of producing a binding protein, the method comprising: a) culturing a host cell according to any of the above embodiments under conditions such that the host cell expresses the binding protein; and b) isolating the binding protein from the host cell. 
     In one embodiment, the disclosure provides a method of preventing and/or treating HIV infection in a patient comprising administering to the patient a therapeutically effective amount of at least one binding protein according to any of the above embodiments. In some embodiments, the binding protein is co-administered with standard anti-retroviral therapy. In some embodiments, administration of the at least one binding protein results in the neutralization of one or more HIV virions. In some embodiments, administration of the at least one binding protein results in the elimination of one or more latently and/or chronically HIV-infected cells in the patient. In some embodiments, the patient is a human. 
     In one embodiment, the disclosure provides a binding protein according to any of the above embodiments for the prevention or treatment of an HIV infection in a patient. In some embodiments, the binding protein is co-administered with standard anti-retroviral therapy. In some embodiments, the binding protein causes the neutralization of one or more HIV virions in the patient. In some embodiments, the binding protein causes the elimination of one or more latently and/or chronically HIV-infected cells in the patient. In some embodiments, the patient is a human. 
     Specific embodiments of the invention will become evident from the following more detailed description of certain embodiments and the claims. 
     It is to be understood that one, some, or all of the properties of the various embodiments described herein may be combined to form other embodiments of the present invention. These and other aspects of the invention will become apparent to one of skill in the art. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIGS. 1A-D  show schematic representations of trispecific binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind three different epitopes on one or more antigens, wherein a first pair of polypeptides possess dual variable domains having a cross-over orientation forming two antigen binding sites (comprising V H1 -V L1  and V H2 -V L2 ) and wherein a second pair of polypeptides possess a single antigen binding site (comprising V H3 -V L3 ), in accordance with some embodiments.  FIG. 1A  shows a trispecific binding protein comprising a “knobs-into-holes” modification, wherein the knob is on the first pair of polypeptides.  FIG. 1B  shows a trispecific binding protein comprising a “knobs-into-holes” modification, wherein the knob is on the second pair of polypeptides.  FIG. 1C  shows the orientation of variable domains on the polypeptide chains, and the knob/hole orientation for binding proteins 1-31 shown in Tables 1 and 2. “Heavy chain A” (e.g., a third polypeptide chain of the present disclosure) indicates the variable domain of heavy chain A. “Light chain A” (e.g., a fourth polypeptide chain of the present disclosure) indicates the variable domain of light chain A. “Heavy chain B” (e.g., a second polypeptide chain of the present disclosure) indicates variable domain 1 and variable domain 2 of heavy chain B. “Light chain B” (e.g., a first polypeptide chain of the present disclosure) indicates variable domain 1 and variable domain 2 of light chain B. 
         FIG. 1D  shows the orientation of variable domains on the polypeptide chains, and the knob/hole orientation for binding proteins 32-53 shown in Tables 1 and 2. “Heavy chain A” (e.g., a third polypeptide chain of the present disclosure) indicates the variable domain of heavy chain A. “Light chain A” (e.g., a fourth polypeptide chain of the present disclosure) indicates the variable domain of light chain A. “Heavy chain B” (e.g., a second polypeptide chain of the present disclosure) indicates variable domain 1 and variable domain 2 of heavy chain B. “Light chain B” (e.g., a first polypeptide chain of the present disclosure) indicates variable domain 1 and variable domain 2 of light chain B. 
         FIGS. 2A-B  show purification of three trispecific binding proteins first using affinity chromatography, and then using preparative size exclusion chromatography.  FIG. 2A  shows the elution profile of the trispecific binding proteins during purification using protein A affinity chromatography.  FIG. 2B  shows purification of monomeric proteins by Superdex200 size exclusion chromatography. 
         FIGS. 3A-B  show purification of the MPER Ab, CD4BS Ab “b”, and V1/V2 directed Ab “a” parental antibodies first using affinity chromatography, and then using preparative size exclusion chromatography.  FIG. 3A  shows the elution profile of the parental antibodies during purification using protein A affinity chromatography.  FIG. 3B  shows purification of monomeric proteins by Superdex200 size exclusion chromatography. 
         FIGS. 4A-B  show the size exclusion chromatography profiles of bispecific and trispecific binding proteins.  FIG. 4A  shows the size exclusion chromatography profiles of the bispecific binding proteins.  FIG. 4B  shows the size exclusion chromatography profiles of the trispecific binding proteins. 
         FIG. 5  shows the Biacore sensograms of the binding kinetics of three trispecific binding proteins and the parental MPER Ab antibody for an HIV gp41-derived peptide (the MPER binding site), as assessed by the standard Biacore-based kinetic assay. 
         FIG. 6  shows the Biacore sensograms of the binding kinetics of three trispecific binding proteins and the parental CD4BS Ab “b” antibody for recombinant HIV gp120, as assessed by the standard Biacore-based kinetic assay. 
         FIG. 7  shows the results of a pharmacokinetic (PK) study of the indicated proteins after intravenous (IV) injection in rhesus macaques. 
         FIGS. 8A-8B  show schematic representations of trispecific T-cell engagers, in accordance with some embodiments. The binding sites are indicated by the dotted circles. 
         FIG. 9  shows binding properties of the trispecific binding proteins “Binding Protein 32” and “CD3×CD28/CD4BS Ab ‘b’” to CD3 (CD3E represents CD3epsilon protein; CD3D represents CD3delta protein), CD28, and Resurfaced Stabilized Core 3 (RSC3) protein of gp120, as well as a negative control (human IgG). 
         FIG. 10  shows CD8 T-cell activation using the trispecific proteins “Binding Protein 32” and “CD3×CD28/CD4BS Ab ‘b’” compared to the parental CD4BS IgG4 antibody, as well as a negative control (No mAb). 
         FIG. 11  shows CD4 T-cell activation using the trispecific proteins “Binding Protein 32” and “CD3×CD28/CD4BS Ab ‘b’” compared to the parental CD4BS IgG4 antibody, as well as a negative control (No mAb). 
         FIG. 12  shows CD3 downregulation after T cell activation by the trispecific proteins “Binding Protein 32” and “CD3×CD28/CD4BS Ab ‘b’” compared to the parental CD4BS IgG4 antibody, as well as a negative control (No mAb). 
         FIGS. 13A-C  show fluorescence-activated cell sorting (FACS)-based cytotoxicity assay results for trispecific binding proteins against latently infected HIV-1 +  T cells.  FIG. 13A  shows the results for trispecific binding proteins incubated with CEM-BaL cells.  FIG. 13B  shows the results for trispecific binding proteins incubated with ACH2 cells.  FIG. 13C  shows the results for trispecific binding proteins incubated with J1.1 cells. 
     
    
    
     DETAILED DESCRIPTION 
     The present disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind to one or more human immunodeficiency virus (HIV) target proteins and/or one or more T-cell receptor target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. 
     The following description sets forth exemplary methods, parameters, and the like. It should be recognized, however, that such description is not intended as a limitation on the scope of the present disclosure but is instead provided as a description of exemplary embodiments. 
     Definitions 
     As utilized in accordance with the present disclosure, the following terms, unless otherwise indicated, shall be understood to have the following meanings. Unless otherwise required by context, singular terms shall include pluralities and plural terms shall include the singular. 
     The term “polynucleotide” as used herein refers to single-stranded or double-stranded nucleic acid polymers of at least 10 nucleotides in length. In certain embodiments, the nucleotides comprising the polynucleotide can be ribonucleotides or deoxyribonucleotides or a modified form of either type of nucleotide. Such modifications include base modifications such as bromuridine, ribose modifications such as arabinoside and 2′,3′-dideoxyribose, and internucleotide linkage modifications such as phosphorothioate, phosphorodithioate, phosphoroselenoate, phosphorodiselenoate, phosphoroanilothioate, phoshoraniladate and phosphoroamidate. The term “polynucleotide” specifically includes single-stranded and double-stranded forms of DNA. 
     An “isolated polynucleotide” is a polynucleotide of genomic, cDNA, or synthetic origin or some combination thereof, which: (1) is not associated with all or a portion of a polynucleotide in which the isolated polynucleotide is found in nature, (2) is linked to a polynucleotide to which it is not linked in nature, or (3) does not occur in nature as part of a larger sequence. 
     An “isolated polypeptide” is one that: (1) is free of at least some other polypeptides with which it would normally be found, (2) is essentially free of other polypeptides from the same source, e.g., from the same species, (3) is expressed by a cell from a different species, (4) has been separated from at least about 50 percent of polynucleotides, lipids, carbohydrates, or other materials with which it is associated in nature, (5) is not associated (by covalent or noncovalent interaction) with portions of a polypeptide with which the “isolated polypeptide” is associated in nature, (6) is operably associated (by covalent or noncovalent interaction) with a polypeptide with which it is not associated in nature, or (7) does not occur in nature. Such an isolated polypeptide can be encoded by genomic DNA, cDNA, mRNA or other RNA, of synthetic origin, or any combination thereof. Preferably, the isolated polypeptide is substantially free from polypeptides or other contaminants that are found in its natural environment that would interfere with its use (therapeutic, diagnostic, prophylactic, research or otherwise). 
     Naturally occurring antibodies typically comprise a tetramer. Each such tetramer is typically composed of two identical pairs of polypeptide chains, each pair having one full-length “light” chain (typically having a molecular weight of about 25 kDa) and one full-length “heavy” chain (typically having a molecular weight of about 50-70 kDa). The terms “heavy chain” and “light chain” as used herein refer to any immunoglobulin polypeptide having sufficient variable domain sequence to confer specificity for a target antigen. The amino-terminal portion of each light and heavy chain typically includes a variable domain of about 100 to 110 or more amino acids that typically is responsible for antigen recognition. The carboxy-terminal portion of each chain typically defines a constant domain responsible for effector function. Thus, in a naturally occurring antibody, a full-length heavy chain immunoglobulin polypeptide includes a variable domain (V H ) and three constant domains (C H1 , C H2 , and C H3 ), wherein the VH domain is at the amino-terminus of the polypeptide and the C H3  domain is at the carboxyl-terminus, and a full-length light chain immunoglobulin polypeptide includes a variable domain (V L ) and a constant domain (C L ), wherein the V L  domain is at the amino-terminus of the polypeptide and the C L  domain is at the carboxyl-terminus. 
     Human light chains are typically classified as kappa and lambda light chains, and human heavy chains are typically classified as mu, delta, gamma, alpha, or epsilon, and define the antibody&#39;s isotype as IgM, IgD, IgG, IgA, and IgE, respectively. IgG has several subclasses, including, but not limited to, IgG1, IgG2, IgG3, and IgG4. IgM has subclasses including, but not limited to, IgM1 and IgM2. IgA is similarly subdivided into subclasses including, but not limited to, IgA1 and IgA2. Within full-length light and heavy chains, the variable and constant domains typically are joined by a “J” region of about 12 or more amino acids, with the heavy chain also including a “D” region of about 10 more amino acids. See, e.g., F UNDAMENTAL  I MMUNOLOGY  (Paul, W., ed., Raven Press, 2nd ed., 1989), which is incorporated by reference in its entirety for all purposes. The variable regions of each light/heavy chain pair typically form an antigen binding site. The variable domains of naturally occurring antibodies typically exhibit the same general structure of relatively conserved framework regions (FR) joined by three hypervariable regions, also called complementarity determining regions or CDRs. The CDRs from the two chains of each pair typically are aligned by the framework regions, which may enable binding to a specific epitope. From the amino-terminus to the carboxyl-terminus, both light and heavy chain variable domains typically comprise the domains FR1, CDR1, FR2, CDR2, FR3, CDR3, and FR4. 
     The term “CDR set” refers to a group of three CDRs that occur in a single variable region capable of binding the antigen. The exact boundaries of these CDRs have been defined differently according to different systems. The system described by Kabat (Kabat et al., S EQUENCES OF  P ROTEINS OF  I MMUNOLOGICAL  I NTEREST  (National Institutes of Health, Bethesda, Md. (1987) and (1991)) not only provides an unambiguous residue numbering system applicable to any variable region of an antibody, but also provides precise residue boundaries defining the three CDRs. These CDRs may be referred to as Kabat CDRs. Chothia and coworkers (Chothia and Lesk, 1987 , J. Mol. Biol.  196: 901-17; Chothia et al., 1989 , Nature  342: 877-83) found that certain sub-portions within Kabat CDRs adopt nearly identical peptide backbone conformations, despite having great diversity at the level of amino acid sequence. These sub-portions were designated as L1, L2, and L3 or H1, H2, and H3 where the “L” and the “H” designates the light chain and the heavy chain regions, respectively. These regions may be referred to as Chothia CDRs, which have boundaries that overlap with Kabat CDRs. Other boundaries defining CDRs overlapping with the Kabat CDRs have been described by Padlan, 1995 , FASEB J.  9: 133-39; MacCallum, 1996 , J. Mol. Biol.  262(5): 732-45; and Lefranc, 2003 , Dev. Comp. Immunol.  27: 55-77. Still other CDR boundary definitions may not strictly follow one of the herein systems, but will nonetheless overlap with the Kabat CDRs, although they may be shortened or lengthened in light of prediction or experimental findings that particular residues or groups of residues or even entire CDRs do not significantly impact antigen binding. The methods used herein may utilize CDRs defined according to any of these systems, although certain embodiments use Kabat or Chothia defined CDRs. Identification of predicted CDRs using the amino acid sequence is well known in the field, such as in Martin, A. C. “Protein sequence and structure analysis of antibody variable domains,”  In Antibody Engineering , Vol. 2. Kontermann R., Dubel S., eds. Springer-Verlag, Berlin, p. 33-51 (2010). The amino acid sequence of the heavy and/or light chain variable domain may be also inspected to identify the sequences of the CDRs by other conventional methods, e.g., by comparison to known amino acid sequences of other heavy and light chain variable regions to determine the regions of sequence hypervariability. The numbered sequences may be aligned by eye, or by employing an alignment program such as one of the CLUSTAL suite of programs, as described in Thompson, 1994 , Nucleic Acids Res.  22: 4673-80. Molecular models are conventionally used to correctly delineate framework and CDR regions and thus correct the sequence-based assignments. 
     The term “Fc” as used herein refers to a molecule comprising the sequence of a non-antigen-binding fragment resulting from digestion of an antibody or produced by other means, whether in monomeric or multimeric form, and can contain the hinge region. The original immunoglobulin source of the native Fc is preferably of human origin and can be any of the immunoglobulins, although IgG1 and IgG2 are preferred. Fc molecules are made up of monomeric polypeptides that can be linked into dimeric or multimeric forms by covalent (i.e., disulfide bonds) and non-covalent association. The number of intermolecular disulfide bonds between monomeric subunits of native Fc molecules ranges from 1 to 4 depending on class (e.g., IgG, IgA, and IgE) or subclass (e.g., IgG1, IgG2, IgG3, IgA1, and IgGA2). One example of a Fc is a disulfide-bonded dimer resulting from papain digestion of an IgG. The term “Fc” as used herein is generic to the monomeric, dimeric, and multimeric forms. 
     A F(ab) fragment typically includes one light chain and the V H  and C H1  domains of one heavy chain, wherein the V H -C H1  heavy chain portion of the F(ab) fragment cannot form a disulfide bond with another heavy chain polypeptide. As used herein, a F(ab) fragment can also include one light chain containing two variable domains separated by an amino acid linker and one heavy chain containing two variable domains separated by an amino acid linker and a C H1  domain. 
     A F(ab′) fragment typically includes one light chain and a portion of one heavy chain that contains more of the constant region (between the C H1  and C H2  domains), such that an interchain disulfide bond can be formed between two heavy chains to form a F(ab′) 2  molecule. 
     The term “binding protein” as used herein refers to a non-naturally occurring (or recombinant or engineered) molecule that specifically binds to at least one target antigen, and which comprises four polypeptide chains that form at least three antigen binding sites, wherein a first polypeptide chain has a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain has a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II]
 
     and a third polypeptide chain has a structure represented by the formula: 
       V H3 -C H1   [III]
 
     and a fourth polypeptide chain has a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     A “recombinant” molecule is one that has been prepared, expressed, created, or isolated by recombinant means. 
     One embodiment of the disclosure provides binding proteins having biological and immunological specificity to between one and three target antigens. Another embodiment of the disclosure provides nucleic acid molecules comprising nucleotide sequences encoding polypeptide chains that form such binding proteins. Another embodiment of the disclosure provides expression vectors comprising nucleic acid molecules comprising nucleotide sequences encoding polypeptide chains that form such binding proteins. Yet another embodiment of the disclosure provides host cells that express such binding proteins (i.e., comprising nucleic acid molecules or vectors encoding polypeptide chains that form such binding proteins). 
     The term “swapability” as used herein refers to the interchangeability of variable domains within the binding protein format and with retention of folding and ultimate binding affinity. “Full swapability” refers to the ability to swap the order of both V H1  and V H2  domains, and therefore the order of V L1  and V L2  domains, in the polypeptide chain of formula I or the polypeptide chain of formula II (i.e., to reverse the order) while maintaining full functionality of the binding protein as evidenced by the retention of binding affinity. Furthermore, it should be noted that the designations VH and VL refer only to the domain&#39;s location on a particular protein chain in the final format. For example, V H1  and V H2  could be derived from V L1  and V L2  domains in parent antibodies and placed into the V H1  and V H2  positions in the binding protein. Likewise, V L1  and V L2  could be derived from V H1  and V H2  domains in parent antibodies and placed in the V H1  and V H2  positions in the binding protein. Thus, the V H  and V L  designations refer to the present location and not the original location in a parent antibody. V H  and V L  domains are therefore “swappable.” 
     The term “antigen” or “target antigen” or “antigen target” as used herein refers to a molecule or a portion of a molecule that is capable of being bound by a binding protein, and additionally is capable of being used in an animal to produce antibodies capable of binding to an epitope of that antigen. A target antigen may have one or more epitopes. With respect to each target antigen recognized by a binding protein, the binding protein is capable of competing with an intact antibody that recognizes the target antigen. 
     The term “HIV” as used herein means Human Immunodeficiency Virus. As used herein, the term “HIV infection” generally encompasses infection of a host, particularly a human host, by the human immunodeficiency virus (HIV) family of retroviruses including, but not limited to, HIV I, HIV II, HIV III (also known as HTLV-II, LAV-1, LAV-2). HIV can be used herein to refer to any strains, forms, subtypes, clades and variations in the HIV family. Thus, treating HIV infection will encompass the treatment of a person who is a carrier of any of the HIV family of retroviruses or a person who is diagnosed with active AIDS, as well as the treatment or prophylaxis of the AIDS-related conditions in such persons. 
     The term “AIDS” as used herein means Acquired Immunodeficiency Syndrome. AIDS is caused by HIV. 
     The terms “CD4bs” or “CD4 binding site” refer to the binding site for CD4 (cluster of differentiation 4), which is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. 
     The term “CD3” is cluster of differentiation factor 3 polypeptide and is a T-cell surface protein that is typically part of the T cell receptor (TCR) complex. 
     “CD28” is cluster of differentiation 28 polypeptide and is a T-cell surface protein that provides co-stimulatory signals for T-cell activation and survival. 
     The term “glycoprotein 160” or “gp160 protein” refers to the envelope glycoprotein complex of HIV and which is a homotrimer that is cleaved into gp120 and gp41 subunits. 
     The term “MPER” refers to the membrane-proximal external region of glycoprotein 41 (gp41), which is a subunit of the envelope protein complex of retroviruses, including HIV. 
     The term “glycan” refers to the carbohydrate portion of a glycoconjugate, such as a glycoprotein, glycolipid, or a proteoglycan. In the disclosed binding proteins, glycan refers to the HIV-1 envelope glycoprotein gp120. 
     The term “T-cell engager” refers to binding proteins directed to a host&#39;s immune system, more specifically the T cells&#39; cytotoxic activity as well as directed to a HIV target protein. 
     The term “trimer apex” refers to apex of HIV-1 envelope glycoprotein gp120. 
     The term “monospecific binding protein” refers to a binding protein that specifically binds to one antigen target. 
     The term “monovalent binding protein” refers to a binding protein that has one antigen binding site. 
     The term “bispecific binding protein” refers to a binding protein that specifically binds to two different antigen targets. 
     The term “bivalent binding protein” refers to a binding protein that has two binding sites. 
     The term “trispecific binding protein” refers to a binding protein that specifically binds to three different antigen targets. 
     The term “trivalent binding protein” refers to a binding protein that has three binding sites. In particular embodiments the trivalent binding protein can bind to one antigen target. In other embodiments, the trivalent binding protein can bind to two antigen targets. In other embodiments, the trivalent binding protein can bind to three antigen targets. 
     An “isolated” binding protein is one that has been identified and separated and/or recovered from a component of its natural environment. Contaminant components of its natural environment are materials that would interfere with diagnostic or therapeutic uses for the binding protein, and may include enzymes, hormones, and other proteinaceous or non-proteinaceous solutes. In some embodiments, the binding protein will be purified: (1) to greater than 95% by weight of antibody as determined by the Lowry method, and most preferably more than 99% by weight, (2) to a degree sufficient to obtain at least 15 residues of N-terminal or internal amino acid sequence by use of a spinning cup sequenator, or (3) to homogeneity by SDS-PAGE under reducing or nonreducing conditions using Coomassie blue or, preferably, silver stain. Isolated binding proteins include the binding protein in situ within recombinant cells since at least one component of the binding protein&#39;s natural environment will not be present. 
     The terms “substantially pure” or “substantially purified” as used herein refer to a compound or species that is the predominant species present (i.e., on a molar basis it is more abundant than any other individual species in the composition). In some embodiments, a substantially purified fraction is a composition wherein the species comprises at least about 50% (on a molar basis) of all macromolecular species present. In other embodiments, a substantially pure composition will comprise more than about 80%, 85%, 90%, 95%, or 99% of all macromolar species present in the composition. In still other embodiments, the species is purified to essential homogeneity (contaminant species cannot be detected in the composition by conventional detection methods) wherein the composition consists essentially of a single macromolecular species. 
     A “neutralizing” binding protein as used herein refers to a molecule that is able to block or substantially reduce an effector function of a target antigen to which it binds. As used herein, “substantially reduce” means at least about 60%, preferably at least about 70%, more preferably at least about 75%, even more preferably at least about 80%, still more preferably at least about 85%, most preferably at least about 90% reduction of an effector function of the target antigen. 
     The term “epitope” includes any determinant, preferably a polypeptide determinant, capable of specifically binding to an immunoglobulin or T-cell receptor. In certain embodiments, epitope determinants include chemically active surface groupings of molecules such as amino acids, sugar side chains, phosphoryl groups, or sulfonyl groups, and, in certain embodiments, may have specific three-dimensional structural characteristics and/or specific charge characteristics. An epitope is a region of an antigen that is bound by an antibody or binding protein. In certain embodiments, a binding protein is said to specifically bind an antigen when it preferentially recognizes its target antigen in a complex mixture of proteins and/or macromolecules. In some embodiments, a binding protein is said to specifically bind an antigen when the equilibrium dissociation constant is ≤10 −8  M, more preferably when the equilibrium dissociation constant is ≤10 −9  M, and most preferably when the dissociation constant is ≤10 −10  M. 
     The dissociation constant (K D ) of a binding protein can be determined, for example, by surface plasmon resonance. Generally, surface plasmon resonance analysis measures real-time binding interactions between ligand (a target antigen on a biosensor matrix) and analyte (a binding protein in solution) by surface plasmon resonance (SPR) using the BIAcore system (Pharmacia Biosensor; Piscataway, N.J.). Surface plasmon analysis can also be performed by immobilizing the analyte (binding protein on a biosensor matrix) and presenting the ligand (target antigen). The term “K D ,” as used herein refers to the dissociation constant of the interaction between a particular binding protein and a target antigen. 
     The term “specifically binds” as used herein refers to the ability of a binding protein or an antigen-binding fragment thereof to bind to an antigen containing an epitope with an Kd of at least about 1×10 −6  M, 1×10 −7  M, 1×10 −8  M, 1×10 −9  M, 1×10 −10  M, 1×10 −11  M, 1×10 −12  M, or more, and/or to bind to an epitope with an affinity that is at least two-fold greater than its affinity for a nonspecific antigen. 
     The term “linker” as used herein refers to one or more amino acid residues inserted between immunoglobulin domains to provide sufficient mobility for the domains of the light and heavy chains to fold into cross over dual variable region immunoglobulins. A linker is inserted at the transition between variable domains or between variable and constant domains, respectively, at the sequence level. The transition between domains can be identified because the approximate size of the immunoglobulin domains are well understood. The precise location of a domain transition can be determined by locating peptide stretches that do not form secondary structural elements such as beta-sheets or alpha-helices as demonstrated by experimental data or as can be assumed by techniques of modeling or secondary structure prediction. The linkers described herein are referred to as L 1 , which is located on the light chain between the C-terminus of the V L2  and the N-terminus of the V L1  domain; and L 2 , which is located on the light chain between the C-terminus of the V L1  and the N-terminus of the C L  domain. The heavy chain linkers are known as L 3 , which is located between the C-terminus of the V H1  and the N-terminus of the V H2  domain; and L 4 , which is located between the C-terminus of the V H2  and the N-terminus of the C H1  domain. 
     The term “vector” as used herein refers to any molecule (e.g., nucleic acid, plasmid, or virus) that is used to transfer coding information to a host cell. The term “vector” includes a nucleic acid molecule that is capable of transporting another nucleic acid to which it has been linked. One type of vector is a “plasmid,” which refers to a circular double-stranded DNA molecule into which additional DNA segments may be inserted. Another type of vector is a viral vector, wherein additional DNA segments may be inserted into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) can be integrated into the genome of a host cell upon introduction into the host cell and thereby are replicated along with the host genome. In addition, certain vectors are capable of directing the expression of genes to which they are operatively linked. Such vectors are referred to herein as “recombinant expression vectors” (or simply, “expression vectors”). In general, expression vectors of utility in recombinant DNA techniques are often in the form of plasmids. The terms “plasmid” and “vector” may be used interchangeably herein, as a plasmid is the most commonly used form of vector. However, the disclosure is intended to include other forms of expression vectors, such as viral vectors (e.g., replication defective retroviruses, adenoviruses, and adeno-associated viruses), which serve equivalent functions. 
     The phrase “recombinant host cell” (or “host cell”) as used herein refers to a cell into which a recombinant expression vector has been introduced. A recombinant host cell or host cell is intended to refer not only to the particular subject cell, but also to the progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but such cells are still included within the scope of the term “host cell” as used herein. A wide variety of host cell expression systems can be used to express the binding proteins, including bacterial, yeast, baculoviral, and mammalian expression systems (as well as phage display expression systems). An example of a suitable bacterial expression vector is pUC19. To express a binding protein recombinantly, a host cell is transformed or transfected with one or more recombinant expression vectors carrying DNA fragments encoding the polypeptide chains of the binding protein such that the polypeptide chains are expressed in the host cell and, preferably, secreted into the medium in which the host cells are cultured, from which medium the binding protein can be recovered. 
     The term “transformation” as used herein refers to a change in a cell&#39;s genetic characteristics, and a cell has been transformed when it has been modified to contain a new DNA. For example, a cell is transformed where it is genetically modified from its native state. Following transformation, the transforming DNA may recombine with that of the cell by physically integrating into a chromosome of the cell, or may be maintained transiently as an episomal element without being replicated, or may replicate independently as a plasmid. A cell is considered to have been stably transformed when the DNA is replicated with the division of the cell. The term “transfection” as used herein refers to the uptake of foreign or exogenous DNA by a cell, and a cell has been “transfected” when the exogenous DNA has been introduced inside the cell membrane. A number of transfection techniques are well known in the art. Such techniques can be used to introduce one or more exogenous DNA molecules into suitable host cells. 
     The term “naturally occurring” as used herein and applied to an object refers to the fact that the object can be found in nature and has not been manipulated by man. For example, a polynucleotide or polypeptide that is present in an organism (including viruses) that can be isolated from a source in nature and that has not been intentionally modified by man is naturally-occurring. Similarly, “non-naturally occurring” as used herein refers to an object that is not found in nature or that has been structurally modified or synthesized by man. 
     As used herein, the twenty conventional amino acids and their abbreviations follow conventional usage. Stereoisomers (e.g.,  D -amino acids) of the twenty conventional amino acids; unnatural amino acids and analogs such as α-, α-disubstituted amino acids, N-alkyl amino acids, lactic acid, and other unconventional amino acids may also be suitable components for the polypeptide chains of the binding proteins. Examples of unconventional amino acids include: 4-hydroxyproline, γ-carboxyglutamate, ε-N,N,N-trimethyllysine, ε-N-acetyllysine, O-phosphoserine, N-acetylserine, N-formylmethionine, 3-methylhistidine, 5-hydroxylysine, σ-N-methylarginine, and other similar amino acids and imino acids (e.g., 4-hydroxyproline). In the polypeptide notation used herein, the left-hand direction is the amino terminal direction and the right-hand direction is the carboxyl-terminal direction, in accordance with standard usage and convention. 
     Naturally occurring residues may be divided into classes based on common side chain properties: 
     (1) hydrophobic: Met, Ala, Val, Leu, Ile, Phe, Trp, Tyr, Pro;
 
(2) polar hydrophilic: Arg, Asn, Asp, Gln, Glu, His, Lys, Ser, Thr;
 
(3) aliphatic: Ala, Gly, Ile, Leu, Val, Pro;
 
(4) aliphatic hydrophobic: Ala, Ile, Leu, Val, Pro;
 
(5) neutral hydrophilic: Cys, Ser, Thr, Asn, Gln;
 
(6) acidic: Asp, Glu;
 
(7) basic: His, Lys, Arg;
 
(8) residues that influence chain orientation: Gly, Pro;
 
(9) aromatic: His, Trp, Tyr, Phe; and
 
(10) aromatic hydrophobic: Phe, Trp, Tyr.
 
     Conservative amino acid substitutions may involve exchange of a member of one of these classes with another member of the same class. Non-conservative substitutions may involve the exchange of a member of one of these classes for a member from another class. 
     A skilled artisan will be able to determine suitable variants of the polypeptide chains of the binding proteins using well-known techniques. For example, one skilled in the art may identify suitable areas of a polypeptide chain that may be changed without destroying activity by targeting regions not believed to be important for activity. Alternatively, one skilled in the art can identify residues and portions of the molecules that are conserved among similar polypeptides. In addition, even areas that may be important for biological activity or for structure may be subject to conservative amino acid substitutions without destroying the biological activity or without adversely affecting the polypeptide structure. 
     The term “patient” as used herein includes human and animal subjects. 
     The terms “treatment” or “treat” as used herein refer to both therapeutic treatment and prophylactic or preventative measures. Those in need of treatment include those having the disorder as well as those prone to have a disorder or those in which the disorder is to be prevented. In particular embodiments, binding proteins can be used to treat humans infected with HIV, or humans susceptible to HIV infection, or ameliorate HIV infection in a human subject infected with HIV. The binding proteins can also be used to prevent HIV in a human patient. 
     It should be understood as that treating humans infected with HIV include those subjects who are at any one of the several stages of HIV infection progression, which, for example, include acute primary infection syndrome (which can be asymptomatic or associated with an influenza-like illness with fevers, malaise, diarrhea and neurologic symptoms such as headache), asymptomatic infection (which is the long latent period with a gradual decline in the number of circulating CD4 +  T cells), and AIDS (which is defined by more serious AIDS-defining illnesses and/or a decline in the circulating CD4 cell count to below a level that is compatible with effective immune function). In addition, treating or preventing HIV infection will also encompass treating suspected infection by HIV after suspected past exposure to HIV by e.g., contact with HIV-contaminated blood, blood transfusion, exchange of body fluids, “unsafe” sex with an infected person, accidental needle stick, receiving a tattoo or acupuncture with contaminated instruments, or transmission of the virus from a mother to a baby during pregnancy, delivery or shortly thereafter. 
     The terms “pharmaceutical composition” or “therapeutic composition” as used herein refer to a compound or composition capable of inducing a desired therapeutic effect when properly administered to a patient. 
     The term “pharmaceutically acceptable carrier” or “physiologically acceptable carrier” as used herein refers to one or more formulation materials suitable for accomplishing or enhancing the delivery of a binding protein. 
     The terms “effective amount” and “therapeutically effective amount” when used in reference to a pharmaceutical composition comprising one or more binding proteins refer to an amount or dosage sufficient to produce a desired therapeutic result. More specifically, a therapeutically effective amount is an amount of a binding protein sufficient to inhibit, for some period of time, one or more of the clinically defined pathological processes associated with the condition being treated. The effective amount may vary depending on the specific binding protein that is being used, and also depends on a variety of factors and conditions related to the patient being treated and the severity of the disorder. For example, if the binding protein is to be administered in vivo, factors such as the age, weight, and health of the patient as well as dose response curves and toxicity data obtained in preclinical animal work would be among those factors considered. The determination of an effective amount or therapeutically effective amount of a given pharmaceutical composition is well within the ability of those skilled in the art. 
     One embodiment of the disclosure provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a binding protein. 
     Trispecific and/or Trivalent Binding Proteins 
     In one embodiment, the binding protein of the disclosure is a trispecific and/or trivalent binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more (e.g., three different) HIV target proteins, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II]
 
     and a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1   [III]
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is an immunoglobulin C H1  heavy chain constant domain; and
 
L 1 , L 2 , L 3  and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     In one embodiment, the binding protein of the disclosure is a trispecific and/or trivalent binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more (e.g., three different) HIV target proteins, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1 -hinge-C H2 -C H3   [II]
 
     and a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1 -hinge-C H2 -C H3   [III]
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is an immunoglobulin C H1  heavy chain constant domain;
 
C H2  is an immunoglobulin C H2  heavy chain constant domain;
 
C H3  is an immunoglobulin C H3  heavy chain constant domain; hinge is an immunoglobulin hinge region connecting the C H1  and C H2  domains; and
 
L 1 , L 2 , L 3  and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     In some embodiments, the first polypeptide chain and the second polypeptide chain have a cross-over orientation that forms two distinct antigen binding sites. In some embodiments, the V H1  and V L1  form a binding pair and form the first antigen binding site. In some embodiments, the V H2  and V L2  form a binding pair and form the second antigen binding site. In some embodiments, the third polypeptide and the fourth polypeptide form a third antigen binding site. In some embodiments, the V H3  and V L3  form a binding pair and form the third antigen binding site. 
     In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 2, 4, 10, 12, 18, 20, 26, 28, 34, 36, 42, 44, 50, 52, 58, 60, 66, 68, 74, 76, 82, 84, 90, 92, 98, 100, 106, 108, 114, 116, 122, 124, 130, 132, 138, 140, 146, 148, 154, 156, 162, 164, 170, 172, 178, 180, 186, 188, 194, 196, 202, 204, 210,212, 218, 220, 226, 228, 233, 235, 241, 243; and V H1 , V H2  and V H3 , are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs:1, 3, 9, 11, 17, 10, 25, 27, 33, 35, 41, 43, 49, 51, 57, 59, 65, 67, 73, 75, 81, 83, 89, 91, 97, 99, 105, 107, 113, 115, 121, 123, 129, 131, 137, 139, 145, 147, 153, 155, 161, 163, 169, 171, 177, 179, 185, 187, 193, 195, 201, 203, 209, 211, 217, 219, 225, 227, 232, 234, 240, 242. In other embodiments, V L1 , V L2  and V L3  each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 266-283; and V H1 , V H2  and V H3  each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-265. In some embodiments, V L1 , V L2  and V L3  are each independently a light chain variable domain comprising a light chain variable domain sequence of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein. In some embodiments, V H1 , V H2  and V H3  are each independently a heavy chain variable domain comprising a heavy chain variable domain sequence of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein. In some embodiments, V L1 , V L2  and V L3  are each independently a light chain variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain sequence of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein. In some embodiments, V H1 , V H2  and V H3  are each independently a heavy chain variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain sequence of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein. 
     In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 303, 305, 311, 313, 319, 321, 327, 329, 335, 337, 343, 345, 351, 353, 359, 361, 367, 369, 375, 377, 383, 385, 391, 393, 399, 401, 407, 409, 415, 417, 423, 425, 431, 433, 439, 441, 447, 449, 455, 457, 463, 465, 471, 473; and V H1 , V H2  and V H3 , are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 302, 304, 310, 312, 318, 320, 326, 328, 334, 336, 342, 344, 350, 352, 358, 360, 366, 368, 374, 376, 382, 384, 390, 392, 398, 400, 406, 408, 414, 416, 422, 424, 430, 432, 438, 440, 446, 448, 454, 456, 462, 464, 470, 472. In other embodiments, V L1 , V L2  and V L3  each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 266-271, 275-277, 488-496; and V H1 , V H2  and V H3  each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-253, 257-259, 479-487. 
     In particular embodiments, the order of the V H1  and V H2  domains, and therefore the order of V L1  and V L2  domains, in the polypeptide chain of formula I or the polypeptide chain of formula II (i.e., to reverse the order) are swapped. 
     In some embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 4 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 4; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 3; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 1; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 2. 
     In some embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 12 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 12; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 11 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 11; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 9 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 9; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 10 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 10. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 20 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 20; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 19 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 19; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 17 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 17; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 18 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 18. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 28 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 28; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 27 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 27; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 25 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 25; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 26 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 26. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 36; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 35 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 35; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 33 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 33; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 34 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 34. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 44 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 44; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 43 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 43; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 41 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 41; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 42 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 42. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 52 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 52; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 51 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 51; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 49 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 49; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 50 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 50. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 60 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 60; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 59 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 59; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 57 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 57; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 58 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 58. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 68 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 68; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 67 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 67; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 65 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 65; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 66 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 66. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 76 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 76; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 75 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 75; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 73 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 73; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 74 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 74. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 84 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 84; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 83 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 83; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 81 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 81; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 82 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 82. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 92 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:92; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 91 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 91; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 89 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 89; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 90 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 90. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 100 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 100; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 99 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 99; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 97 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 97; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 98 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 98. 
     In other embodiments, the first polypeptide comprises the amino acid sequence of SEQ ID NO: 108 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 108; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 107 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 107; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 105 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 105; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 106 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 106. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 116 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 116; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 115 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 115; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 113 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 113; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 114 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 114. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 124 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 124; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 123 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 123; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 121 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 121; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 122 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 122. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 132 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 132; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 131 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 131; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 129 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 129; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 130 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 130. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 140 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 140; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 139 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 139; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 137 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 137; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 138 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 138. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 148 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 148; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 147 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 147; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 145 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 145; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 146 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 146. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 156 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 156; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 155 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 155; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 153 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 153; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 154 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 154. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 164 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 164; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 163 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 163; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 161 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 161; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 162 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 162. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 172 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 172; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 171 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 171; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 169 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 169; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 170 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 170. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 180 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 180; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 179 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 179; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 177 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 177; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 178 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 178. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 188 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 188; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 187 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 187; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 185 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 185; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 186 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 186. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 196 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 196; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 195 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 195; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 193 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 193; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 194 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 194. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 204 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 204; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 203 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 203; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 201 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 201; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 202 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 202. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 212 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 212; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 211 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 211; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 209 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 209; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 210 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 210. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 220 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 220; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 219 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 219; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 217 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 217; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 218 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 218. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 228 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 228; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 227 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 227; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 225 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 225; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 226 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 226. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 235 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 235; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 234 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 234; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 232 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 232; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 233 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 233. 
     In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 243 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 243; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 242 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 242; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 240 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 240; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 241 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 241. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 305 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 305; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 304 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 304; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 302 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 302; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 303 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 303. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 313 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 313; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 312 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 312; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 310 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 310; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 311 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 311. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 321 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 321; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 320 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 320; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 318 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 318; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 319 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 319. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 329 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 329; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 328 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 328; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 326 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 326; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 327 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 327. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 337 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 337; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 336 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 336; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 334 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 334; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 335 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 335. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 345 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 345; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 344 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 344; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 342 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 342; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 343 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 343. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 353 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 353; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 352 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:352; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 350 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 350; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 351 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 351. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 361 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 361; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 360 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 360; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 358 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 358; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 359 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 359. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 369 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 369; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 368 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 368; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 366 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 366; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 367 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 367. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 377 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 377; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 376 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 376; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 374 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 374; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 375 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 375. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 385 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 385; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 384 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 384; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 382 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 382; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 383 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 383. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 393 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 393; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 392 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 392; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 390 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 390; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 391 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 391. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 401 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 401; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 400 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 400; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 398 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 398; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 399 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 399. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 409 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 409; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 408 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 408; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 406 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 406; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 407 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 407. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 417 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 417; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 416 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 416; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 414 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 414; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 415 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 415. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 425 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 425; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 424 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 424; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 422 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 422; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 423 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 423. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 433 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:433; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 432 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 432; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 430 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 430; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 431 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 431. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 441 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 441; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 440 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 440; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 438 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 438; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 439 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 439. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 449 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 449; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 448 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 448; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 446 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 446; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 447 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 447. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 457 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 457; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 456 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 456; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 454 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 454; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 455 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 455. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 465 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 465; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 464 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 464; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 462 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 462; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 463 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 463. 
     In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 473 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 473; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 472 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 472; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 470 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 470; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 471 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 471. 
     In other embodiments, the binding protein of the disclosure is a trispecific and/or trivalent binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more (e.g., three) HIV target antigens, wherein a first polypeptide chain has a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain has a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1 -hinge-C H2 -C H3  (hole)  [II]
 
     and a third polypeptide chain has a structure represented by the formula: 
       V H3 -C H1 -hinge-C H2 -C H3  (knob)  [III]
 
     and a fourth polypeptide chain has a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain; and
 
L 1 , L 2 , L 3  and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     In other embodiments, the binding protein of the disclosure is a trispecific and/or trivalent binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more (e.g., three) HIV target antigens, wherein a first polypeptide chain has a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain has a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1 -hinge-C H2 -C H3  (knob)  [II]
 
     and a third polypeptide chain has a structure represented by the formula: 
       V H3 -C H1 -hinge-C H2 -C H3  (hole)  [III]
 
     and a fourth polypeptide chain has a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain; and
 
L 1 , L 2 , L 3  and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     Additional Examples of Trispecific Binding Proteins 
     In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. In some embodiments, VL, V L2  and V L3  are each independently a variable domain comprising an amino acid sequence having at least about 80%, at least about 81%, at least about 82%, at least about 83%, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, at least about 90%, at least about 91%, at least about 92%, at least about 93%, at least about 94%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, or at least about 99% sequence identity to a sequence as set forth in any one of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. 
     In some embodiments, V H1 , V H2  and V H3  are each independently a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. In some embodiments, V H1 , V H2  and V H3  are each independently a variable domain comprising an amino acid sequence having at least about 80%, at least about 81%, at least about 82%, at least about 83%, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, at least about 90%, at least about 91%, at least about 92%, at least about 93%, at least about 94%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, or at least about 99% sequence identity to a sequence as set forth in any one of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. 
     In some embodiments, V L1 , V L2 , and V L3  comprise an amino acid sequence as set forth in SEQ ID NOs: 518, 519, and 512, respectively, and V H1 , V H2 , and V H3  comprise an amino acid sequence as set forth in SEQ ID NOs: 504, 506, and 502, respectively. In some embodiments, V L1 , V L2 , and V L3  comprise an amino acid sequence as set forth in SEQ ID NOs: 518, 519, and 513, respectively, and V H1 , V H2 , and V H3  comprises an amino acid sequence as set forth in SEQ ID NOs: 504, 506, and 503, respectively. In some embodiments, V L1 , V L2 , and V L3  comprises an amino acid sequence as set forth in SEQ ID NOs: 519, 518, and 513, respectively, and V H1 , V H2 , and V H3  comprises an amino acid sequence as set forth in SEQ ID NOs: 506, 504, and 503, respectively. 
     In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. In some embodiments, V H1 , V H2  and V H3  are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a light chain variable domain sequence shown in Table C. In some embodiments, V H1 , V H2  and V H3  are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a heavy chain variable domain sequence shown in Table C. 
     In some embodiments, V L1  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 518, V L2  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 519, V L3  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 512, V H1  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 504, V H2  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 506, and V H3  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 502. In some embodiments, V L1  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 518, V L2  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 519, V L3  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 513, V H1  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 504, V H2  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 506, and V H3  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 503. In some embodiments, V L1  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 519, V L2  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 518, V L3  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 513, and V H1  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 506, V H2  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 504, and V H3  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 503. 
     In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain comprising: (a) a CDR-L1 comprising a sequence selected from the group consisting of SEQ ID NOs: 266, 269, 275, 278, 281, and 500; (b) a CDR-L2 comprising a sequence selected from the group consisting of SEQ ID NOs: 267, 270, 276, 279, 282, and 501; and/or (c) a CDR-L3 comprising a sequence selected from the group consisting of SEQ ID NOs: 268, 271, 274, 277, 280, and 283. In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 comprising amino acid sequences as shown in Table B. In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; or a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively. 
     In some embodiments, V H1 , V H2  and V H3  are each independently a variable domain comprising: (a) a CDR-H1 comprising a sequence selected from the group consisting of SEQ ID NOs: 248, 251, 254, 257, 263, and 499; (b) a CDR-H2 comprising a sequence selected from the group consisting of SEQ ID NOs: 252, 255, 258, 261, 264, and 497; and/or (c) a CDR-H3 comprising a sequence selected from the group consisting of SEQ ID NOs: 250, 253, 256, 259, 262, 265, and 498. In some embodiments, V H1 , V H2  and V H3  are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 comprising amino acid sequences as shown in Table B. In some embodiments, V H1 , V H2  and V H3  are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; or a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively. 
     In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 500, 501, and 274, respectively; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 275, 276, and 277, respectively; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 266, 267, and 268, respectively; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 254, 255, and 256, respectively; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 257, 258, and 259, respectively; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 248, 497, and 250, respectively. In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 500, 501, and 274, respectively; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 275, 276, and 277, respectively; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 269, 270, and 271, respectively; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 254, 255, and 256, respectively; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 257, 258, and 259, respectively; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 251, 252, and 253, respectively. In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 275, 276, and 277, respectively; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 500, 501, and 274, respectively; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 269, 270, and 271, respectively; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 257, 258, and 259, respectively; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 254, 255, and 256, respectively; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 251, 252, and 253, respectively. 
     Additional Trispecific Binding Proteins Targeting One or More HIV Target Proteins and One or More T Cell Target Proteins 
     In some embodiments, a binding protein of the present disclosure comprises four polypeptide chains that form three antigen binding sites that specifically bind one or more (e.g., one or two) HIV target proteins and one or more (e.g., one or two) T cell target proteins, wherein a first polypeptide chain has a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I];
 
     a second polypeptide chain has a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II];
 
     a third polypeptide chain has a structure represented by the formula: 
       V H3 -C H1   [III];
 
     and a fourth polypeptide chain has a structure represented by the formula: 
       V L3 -C L   [IV];
 
     wherein
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is an immunoglobulin C H1  heavy chain constant domain; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     In some embodiments, a binding protein of the present disclosure comprises four polypeptide chains that form three antigen binding sites that specifically bind one or more (e.g., one or two) HIV target proteins and one or more (e.g., one or two) T cell target proteins, wherein a first polypeptide chain has a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     a second polypeptide chain has a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1 -hinge-C H2 -C H3   [II];
 
     a third polypeptide chain has a structure represented by the formula: 
       V H3 -C H1 -hinge-C H2 -C H3   [III];
 
     and a fourth polypeptide chain has a structure represented by the formula 
       V L3 -C L   [IV];
 
     wherein
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is an immunoglobulin C H1  heavy chain constant domain;
 
C H2  is an immunoglobulin C H2  heavy chain constant domain;
 
C H3  is an immunoglobulin C H3  heavy chain constant domain; hinge is an immunoglobulin hinge region connecting the C H1  and C H2  domains; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     In some embodiments, the first polypeptide chain and the second polypeptide chain have a cross-over orientation that forms two distinct antigen binding sites. In some embodiments, the V H1  and V L1  form a binding pair and form the first antigen binding site. In some embodiments, the V H2  and V L2  form a binding pair and form the second antigen binding site. In some embodiments, the third polypeptide and the fourth polypeptide form a third antigen binding site. In some embodiments, the V H3  and V L3  form a binding pair and form the third antigen binding site. 
     In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain comprising an amino acid sequence having at least about 80%, at least about 81%, at least about 82%, at least about 83%, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, at least about 90%, at least about 91%, at least about 92%, at least about 93%, at least about 94%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, or at least about 99% sequence identity to a sequence as set forth in any one of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. 
     In some embodiments, V H1 , V H2  and V H3  are each independently a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. In some embodiments, V H1 , V H2  and V H3  are each independently a variable domain comprising an amino acid sequence having at least about 80%, at least about 81%, at least about 82%, at least about 83%, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, at least about 90%, at least about 91%, at least about 92%, at least about 93%, at least about 94%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, or at least about 99% sequence identity to a sequence as set forth in any one of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. 
     In some embodiments, V L1 , V L2 , and V L3  comprise an amino acid sequence as set forth in SEQ ID NOs: 522, 524, and 513, respectively, and V H1 , V H2 , and V H3  comprise an amino acid sequence as set forth in SEQ ID NOs: 509, 511, and 503, respectively. In some embodiments, V L1 , V L2 , and V L3  comprise an amino acid sequence as set forth in SEQ ID NOs: 524, 522, and 513, respectively, and V H1 , V H2 , and V H3  comprise an amino acid sequence as set forth in SEQ ID NOs: 511, 509, and 503, respectively. 
     In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. 
     In some embodiments, V H1 , V H2  and V H3  are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. 
     In some embodiments, V L1  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 522, V L2  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 524, V L3  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 513, V H1  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 509, V H2  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 511, and V H3  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 503. In some embodiments, V L1  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 524, V L2  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 522, V L3  is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a light chain variable domain sequence of SEQ ID NO: 513, V H1  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 511, V H2  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 509, and V H3  is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 503. 
     In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain comprising: (a) a CDR-L1 comprising a sequence selected from the group consisting of SEQ ID NOs: 266, 269, 275, 278, 281, 488, 491, 494 and 500; (b) a CDR-L2 comprising a sequence selected from the group consisting of SEQ ID NOs: 267, 270, 276, 279, 282, 489, 492, 495, and 501; and (c) a CDR-L3 comprising a sequence selected from the group consisting of SEQ ID NOs: 268, 271, 274, 277, 280, 283, 490, 493, and 496. In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 comprising amino acid sequences as shown in Table B. In some embodiments, V L1 , V L2  and V L3  are each independently a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively; a sequence as set forth in SEQ ID NOs: 488, 489, and 490, respectively; a sequence as set forth in SEQ ID NOs: 491, 492, and 493, respectively; or a sequence as set forth in SEQ ID NOs: 494, 495, and 496, respectively. 
     In some embodiments, V H1 , V H2  and V H3  are each independently a variable domain comprising: (a) a CDR-H1 comprising a sequence selected from the group consisting of SEQ ID NOs: 248, 251, 254, 257, 263, 479, 482, 485, and 499; (b) a CDR-H2 comprising a sequence selected from the group consisting of SEQ ID NOs: 252, 255, 258, 261, 264, 480, 483, 486, and 497; and (c) a CDR-H3 comprising a sequence selected from the group consisting of SEQ ID NOs: 250, 253, 256, 259, 262, 265, 481, 484, 487, and 498. In some embodiments, V H1 , V H2  and V H3  are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 comprising amino acid sequences as shown in Table B. In some embodiments, V H1 , V H2  and V H3  are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively; a sequence as set forth in SEQ ID NOs: 479, 480, and 481, respectively; a sequence as set forth in SEQ ID NOs: 482, 483, and 484, respectively; or a sequence as set forth in SEQ ID NOs: 485, 486, and 487, respectively. 
     In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 488, 489, and 490, respectively; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 494, 495, and 496, respectively; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 269, 270, and 271, respectively; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 479, 480, and 481, respectively; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 485, 486, and 487, respectively; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 251, 252, and 253, respectively. In some embodiments, V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 494, 495, and 496, respectively; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 488, 489, and 490, respectively; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 269, 270, and 271, respectively; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 485, 486, and 487, respectively; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 479, 480, and 481, respectively; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 251, 252, and 253, respectively. 
     In some embodiments, V L1  and V H1  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD28 or CD28_2 described herein, V L2  and V H2  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD3 described herein, and V L3  and V H3  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein. In some embodiments, V L1  and V H1  are light and heavy chain variable domains comprising the six CDRs of antibody CD28 or CD28_2 described herein, V L2  and V H2  are light and heavy chain variable domains comprising the six CDRs of antibody CD3 described herein, and V L3  and V H3  are light and heavy chain variable domains comprising the six CDRs of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein. 
     In some embodiments, V L1  and V H1  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD28 or CD28_2 described herein, V L2  and V H2  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein, and V L3  and V H3  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD3 described herein. In some embodiments, V L1  and V H1  are light and heavy chain variable domains comprising the six CDRs of antibody CD28 or CD28_2 described herein, V L2  and V H2  are light and heavy chain variable domains comprising the six CDRs of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein, and V L3  and V H3  are light and heavy chain variable domains comprising the six CDRs of antibody CD3 described herein. 
     In some embodiments, V L1  and V H1  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD3 described herein, V L2  and V H2  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD28 or CD28_2 described herein, and V L3  and V H3  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein. In some embodiments, V L1  and V H1  are light and heavy chain variable domains comprising the six CDRs of antibody CD3 described herein, V L2  and V H2  are light and heavy chain variable domains comprising the six CDRs of antibody CD28 or CD28_2 described herein, and V L3  and V H3  are light and heavy chain variable domains comprising the six CDRs of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein. 
     In some embodiments, V L1  and V H1  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD3 described herein, V L2  and V H2  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein, and V L3  and V H3  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD28 or CD28_2 described herein. In some embodiments, V L1  and V H1  are light and heavy chain variable domains comprising the six CDRs of antibody CD3 described herein, V L2  and V H2  are light and heavy chain variable domains comprising the six CDRs of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein, and V L3  and V H3  are light and heavy chain variable domains comprising the six CDRs of antibody CD28 or CD28_2 described herein. 
     In some embodiments, V L1  and V H1  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein, V L2  and V H2  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD28 or CD28_2 described herein, and V L3  and V H3  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD3 described herein. In some embodiments, V L1  and V H1  are light and heavy chain variable domains comprising the six CDRs of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein, V L2  and V H2  are light and heavy chain variable domains comprising the six CDRs of antibody CD28 or CD28_2 described herein, and V L3  and V H3  are light and heavy chain variable domains comprising the six CDRs of antibody CD3 described herein. 
     In some embodiments, V L1  and V H1  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein, V L2  and V H2  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD3 described herein, and V L3  and V H3  are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD28 or CD28_2 described herein. In some embodiments, V L1  and V H1  are light and heavy chain variable domains comprising the six CDRs of antibody CD4BS “a”, CD4BS “b”, MPER, MPER_100W, V1/V2 directed “a”, V1/V2 directed “b”, or V3 directed described herein, V L2  and V H2  are light and heavy chain variable domains comprising the six CDRs of antibody CD3 or CD28_2 described herein, and V L3  and V H3  are light and heavy chain variable domains comprising the six CDRs of antibody CD28 or CD28_2 described herein. 
     Target Proteins 
     In one embodiment, the binding proteins specifically bind to one or more HIV target proteins. In some embodiments, the binding proteins are trispecific and specifically bind to MPER of the HIV-1 gp41 protein, a CD4 binding site of the HIV-1 gp120 protein, a glycan in the V3 loop of the HIV-1 gp120 protein, a trimer apex of the HIV-1 gp120 protein or gp160. In other embodiments, the binding proteins specifically bind to one or more HIV target proteins and one or more target proteins on a T-cell including T cell receptor complex. These T-cell engager binding proteins are capable of recruiting T cells transiently to target cells and, at the same time, activating the cytolytic activity of the T cells. The T-cell engager trispecific antibodies can be used to activate HIV-1 reservoirs and redirect/activate T cells to lyse latently infected HIV-1 +  T cells. Examples of target proteins on T cells include but are not limited to CD3 and CD28, among others. In some embodiments, the trispecific binding proteins may be generated by combining the antigen binding domains of two or more monospecific antibodies (parent antibodies) into one antibody. See International Publication Nos. WO 2011/038290 A2, WO 2013/086533 A1, WO 2013/070776 A1, WO 2012/154312 A1, and WO 2013/163427 A1, which are hereby incorporated into this disclosure by reference. The binding proteins of the disclosure may be prepared using domains or sequences obtained or derived from any human or non-human antibody, including, for example, human, murine, or humanized antibodies. 
     In some embodiments of the disclosure, the trivalent binding protein is capable of binding three different antigen targets. In one embodiment, the binding protein is trispecific and one light chain-heavy chain pair is capable of binding two different antigen targets or epitopes and one light chain-heavy chain pair is capable of binding one antigen target or epitope. In another embodiment, the binding protein is capable of binding three different HIV antigen targets that are located on the HIV envelope glycoprotein structure composed of gp120 and gp41 subunits. In other embodiments, the binding protein is capable of inhibiting the function of one or more of the antigen targets. 
     In some embodiments, a binding protein of the present disclosure binds one or more HIV target proteins. In some embodiments, the binding protein is capable of specifically binding three different epitopes on a single HIV target protein. In some embodiments, the binding protein is capable of binding two different epitopes on a first HIV target protein, and one epitope on a second HIV target protein. In some embodiments, the first and second HIV target proteins are different. In some embodiments, the binding protein is capable of specifically binding three different HIV target protein. In some embodiments, the one or more HIV target proteins are one or more of glycoprotein 120, glycoprotein 41, and glycoprotein 160. 
     In some embodiments, a binding protein of the present disclosure binds one or more HIV target proteins and one or more T cell target proteins. In some embodiments, the binding protein is capable of specifically binding one HIV target protein and two different epitopes on a single T cell target protein. In some embodiments, the binding protein is capable of specifically binding one HIV target protein and two different T cell target proteins (e.g., CD28 and CD3). In some embodiments, the binding protein is capable of specifically binding one T cell target protein and two different epitopes on a single HIV target protein. In some embodiments, the binding protein is capable of specifically binding one T cell target protein and two different HIV target proteins. In some embodiments, the first and second polypeptide chains of the binding protein form two antigen binding sites that specifically target two T cell target proteins, and the third and fourth polypeptide chains of the binding protein form an antigen binding site that specifically binds an HIV target protein. In some embodiments, the one or more HIV target proteins are one or more of glycoprotein 120, glycoprotein 41, and glycoprotein 160. In some embodiments, the one or more T cell target proteins are one or more of CD3 and CD28. 
     Linkers 
     In some embodiments, the linkers L 1 , L 2 , L 3 , and L 4  range from no amino acids (length=0) to about 100 amino acids long, or less than 100, 50, 40, 30, 20, or 15 amino acids or less. The linkers can also be 10, 9, 8, 7, 6, 5, 4, 3, 2, or 1 amino acids long. L 1 , L 2 , L 3 , and L 4  in one binding protein may all have the same amino acid sequence or may all have different amino acid sequences. 
     Examples of suitable linkers include a single glycine (Gly) residue; a diglycine peptide (Gly-Gly); a tripeptide (Gly-Gly-Gly); a peptide with four glycine residues (Gly-Gly-Gly-Gly; SEQ ID NO: 285); a peptide with five glycine residues (Gly-Gly-Gly-Gly-Gly; SEQ ID NO: 286); a peptide with six glycine residues (Gly-Gly-Gly-Gly-Gly-Gly; SEQ ID NO: 287); a peptide with seven glycine residues (Gly-Gly-Gly-Gly-Gly-Gly-Gly; SEQ ID NO: 288); a peptide with eight glycine residues (Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly; SEQ ID NO: 289). Other combinations of amino acid residues may be used such as the peptide Gly-Gly-Gly-Gly-Ser (SEQ ID NO: 290), the peptide Gly-Gly-Gly-Gly-Ser-Gly-Gly-Gly-Gly-Ser (SEQ ID NO: 291) and the peptide Gly-Gly-Gly-Gly-Ser-Gly-Gly-Gly-Gly-Ser-Gly-Gly-Gly-Gly-Ser (SEQ ID NO: 292). Other suitable linkers include a single Ser, and Val residue; the dipeptide Arg-Thr, Gln-Pro, Ser-Ser, Thr-Lys, and Ser-Leu; Thr-Lys-Gly-Pro-Ser (SEQ ID NO: 293), Thr-Val-Ala-Ala-Pro (SEQ ID NO: 294), Gln-Pro-Lys-Ala-Ala (SEQ ID NO: 295), Gln-Arg-Ile-Glu-Gly (SEQ ID NO: 296); Ala-Ser-Thr-Lys-Gly-Pro-Ser (SEQ ID NO: 297), Arg-Thr-Val-Ala-Ala-Pro-Ser (SEQ ID NO: 298), Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299), and His-Ile-Asp-Ser-Pro-Asn-Lys (SEQ ID NO: 300). The examples listed above are not intended to limit the scope of the disclosure in any way, and linkers comprising randomly selected amino acids selected from the group consisting of valine, leucine, isoleucine, serine, threonine, lysine, arginine, histidine, aspartate, glutamate, asparagine, glutamine, glycine, and proline have been shown to be suitable in the binding proteins. 
     The identity and sequence of amino acid residues in the linker may vary depending on the type of secondary structural element necessary to achieve in the linker. For example, glycine, serine, and alanine are best for linkers having maximum flexibility. Some combination of glycine, proline, threonine, and serine are useful if a more rigid and extended linker is necessary. Any amino acid residue may be considered as a linker in combination with other amino acid residues to construct larger peptide linkers as necessary depending on the desired properties. 
     In some embodiments, the length of L 1  is at least twice the length of L 3 . In some embodiments, the length of L 2  is at least twice the length of L 4 . In some embodiments, the length of L 1  is at least twice the length of L 3 , and the length of L 2  is at least twice the length of L 4 . In some embodiments, L 1  is 3 to 12 amino acid residues in length, L 2  is 3 to 14 amino acid residues in length, L 3  is 1 to 8 amino acid residues in length, and L 4  is 1 to 3 amino acid residues in length. In some embodiments, L 1  is 5 to 10 amino acid residues in length, L 2  is 5 to 8 amino acid residues in length, L 3  is 1 to 5 amino acid residues in length, and L 4  is 1 to 2 amino acid residues in length. In some embodiments, L 1  is 7 amino acid residues in length, L 2  is 5 amino acid residues in length, L 3  is 1 amino acid residue in length, and L 4  is 2 amino acid residues in length. 
     In some embodiments, L 1 , L 2 , L 3 , and/or L 4  comprise the sequence Asp-Lys-Thr-His-Thr (SEQ ID NO: 525). In some embodiments, L 1  comprises the sequence Asp-Lys-Thr-His-Thr (SEQ ID NO: 525). In some embodiments, L 3  comprises the sequence Asp-Lys-Thr-His-Thr (SEQ ID NO: 525). 
     In some embodiments, L 1 , L 2 , L 3 , and/or L 4  comprise the sequence Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299). In some embodiments, L 1  comprises the sequence Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299). In some embodiments, L 1  comprises the sequence Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299), L 2  comprises the sequence Thr-Lys-Gly-Pro-Ser-Arg (SEQ ID NO: 526), L 3  comprises the sequence Ser, and L 4  comprises the sequence Arg-Thr. In some embodiments, L 3  comprises the sequence Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299). In some embodiments, L 1  comprises the sequence Ser, L 2  comprises the sequence Arg-Thr, L 3  comprises the sequence Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299) and L 4  comprises the sequence Thr-Lys-Gly-Pro-Ser-Arg (SEQ ID NO: 526). 
     Fc Regions and Constant Domains 
     In some embodiments, a binding protein of the present disclosure comprises a second polypeptide chain further comprising an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. In some embodiments, a binding protein of the present disclosure comprises a third polypeptide chain further comprising an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. In some embodiments, a binding protein of the present disclosure comprises a second polypeptide chain further comprising an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, and a third polypeptide chain further comprising an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. 
     To improve the yields of the binding proteins, in some embodiments, the C H3  domains can be altered by the “knob-into-holes” technology which is described in detail with several examples in, for example, International Publication No. WO 96/027011, Ridgway et al., 1996 , Protein Eng.  9: 617-21; and Merchant et al., 1998 , Nat. Biotechnol.  16: 677-81. Specifically, the interaction surfaces of the two C H3  domains are altered to increase the heterodimerisation of both heavy chains containing these two C H3  domains. Each of the two C H3  domains (of the two heavy chains) can be the “knob,” while the other is the “hole.” The introduction of a disulfide bridge further stabilizes the heterodimers (Merchant et al., 1998; Atwell et al., 1997 , J. Mol. Biol.  270: 26-35) and increases the yield. In particular embodiments, the knob is on the second pair of polypeptides with a single variable domain. In other embodiments, the knob is on the first pair of polypeptides having the cross-over orientation. In yet other embodiments, the C H3  domains do not include a knob in hole. 
     In some embodiments, a binding protein of the present disclosure comprises a “knob” mutation on the second polypeptide chain and a “hole” mutation on the third polypeptide chain. In some embodiments, a binding protein of the present disclosure comprises a “knob” mutation on the third polypeptide chain and a “hole” mutation on the second polypeptide chain. In some embodiments, the “knob” mutation comprises substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index. In some embodiments, the amino acid substitutions are S354C and T366W. In some embodiments, the “hole” mutation comprises substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index. In some embodiments, the amino acid substitutions are Y349C, T366S, L368A, and Y407V. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and 
     wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. 
     In some embodiments, a binding protein of the present disclosure comprises one or more mutations to improve serum half-life (See e.g., Hinton, P. R. et al. (2006)  J. Immunol.  176(1):346-56). In some embodiments, the mutation comprises substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. In some embodiments, the binding protein comprises a second polypeptide chain further comprising a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, and a third polypeptide chain further comprising a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. In some embodiments, a binding protein of the present disclosure comprises knob and hole mutations and one or more mutations to improve serum half-life. 
     In some embodiments, C H1 , C H2 , C H3  and C L  of the trispecific binding proteins described herein may comprise any of C H1 , C H2 , C H3  and C L  sequences of binding proteins 1-53. 
     Nucleic Acids 
     Standard recombinant DNA methodologies are used to construct the polynucleotides that encode the polypeptides which form the binding proteins, incorporate these polynucleotides into recombinant expression vectors, and introduce such vectors into host cells. See e.g., Sambrook et al., 2001, M OLECULAR  C LONING: A  L ABORATORY  M ANUAL  (Cold Spring Harbor Laboratory Press, 3rd ed.). Enzymatic reactions and purification techniques may be performed according to manufacturer&#39;s specifications, as commonly accomplished in the art, or as described herein. Unless specific definitions are provided, the nomenclature utilized in connection with, and the laboratory procedures and techniques of, analytical chemistry, synthetic organic chemistry, and medicinal and pharmaceutical chemistry described herein are those well-known and commonly used in the art. Similarly, conventional techniques may be used for chemical syntheses, chemical analyses, pharmaceutical preparation, formulation, delivery, and treatment of patients. 
     Other aspects of the present disclosure relate to isolated nucleic acid molecules comprising a nucleotide sequence encoding any of the binding proteins described herein. In some embodiments, the isolated nucleic acid is operably linked to a heterologous promoter to direct transcription of the binding protein-coding nucleic acid sequence. A promoter may refer to nucleic acid control sequences which direct transcription of a nucleic acid. A first nucleic acid sequence is operably linked to a second nucleic acid sequence when the first nucleic acid sequence is placed in a functional relationship with the second nucleic acid sequence. For instance, a promoter is operably linked to a coding sequence of a binding protein if the promoter affects the transcription or expression of the coding sequence. Examples of promoters may include, but are not limited to, promoters obtained from the genomes of viruses (such as polyoma virus, fowlpox virus, adenovirus (such as Adenovirus 2), bovine papilloma virus, avian sarcoma virus, cytomegalovirus, a retrovirus, hepatitis-B virus, Simian Virus 40 (SV40), and the like), from heterologous eukaryotic promoters (such as the actin promoter, an immunoglobulin promoter, from heat-shock promoters, and the like), the CAG-promoter (Niwa et al., Gene 108(2):193-9, 1991), the phosphoglycerate kinase (PGK)-promoter, a tetracycline-inducible promoter (Masui et al., Nucleic Acids Res. 33:e43, 2005), the lac system, the trp system, the tac system, the trc system, major operator and promoter regions of phage lambda, the promoter for 3-phosphoglycerate kinase, the promoters of yeast acid phosphatase, and the promoter of the yeast alpha-mating factors. Polynucleotides encoding binding proteins of the present disclosure may be under the control of a constitutive promoter, an inducible promoter, or any other suitable promoter described herein or other suitable promoter that will be readily recognized by one skilled in the art. 
     In some embodiments, the isolated nucleic acid is incorporated into a vector. In some embodiments, the vector is an expression vector. Expression vectors may include one or more regulatory sequences operatively linked to the polynucleotide to be expressed. The term “regulatory sequence” includes promoters, enhancers and other expression control elements (e.g., polyadenylation signals). Examples of suitable enhancers may include, but are not limited to, enhancer sequences from mammalian genes (such as globin, elastase, albumin, α-fetoprotein, insulin and the like), and enhancer sequences from a eukaryotic cell virus (such as SV40 enhancer on the late side of the replication origin (bp 100-270), the cytomegalovirus early promoter enhancer, the polyoma enhancer on the late side of the replication origin, adenovirus enhancers, and the like). Examples of suitable vectors may include, for example, plasmids, cosmids, episomes, transposons, and viral vectors (e.g., adenoviral, vaccinia viral, Sindbis-viral, measles, herpes viral, lentiviral, retroviral, adeno-associated viral vectors, etc.). Expression vectors can be used to transfect host cells, such as, for example, bacterial cells, yeast cells, insect cells, and mammalian cells. Biologically functional viral and plasmid DNA vectors capable of expression and replication in a host are known in the art, and can be used to transfect any cell of interest. 
     Other aspects of the present disclosure relate to a vector system comprising one or more vectors encoding a first, second, third, and fourth polypeptide chain of any of the binding proteins described herein. In some embodiments, the vector system comprises a first vector encoding the first polypeptide chain of the binding protein, a second vector encoding the second polypeptide chain of the binding protein, a third vector encoding the third polypeptide chain of the binding protein, and a fourth vector encoding the fourth polypeptide chain of the binding protein. In some embodiments, the vector system comprises a first vector encoding the first and second polypeptide chains of the binding protein, and a second vector encoding the third and fourth polypeptide chains of the binding protein. In some embodiments, the vector system comprises a first vector encoding the first and third polypeptide chains of the binding protein, and a second vector encoding the second and fourth polypeptide chains of the binding protein. In some embodiments, the vector system comprises a first vector encoding the first and fourth polypeptide chains of the binding protein, and a second vector encoding the second and third polypeptide chains of the binding protein. In some embodiments, the vector system comprises a first vector encoding the first, second, third, and fourth polypeptide chains of the binding protein. The one or more vectors of the vector system may be any of the vectors described herein. In some embodiments, the one or more vectors are expression vectors. 
     Host Cells 
     Other aspects of the present disclosure relate to a host cell (e.g., an isolated host cell) comprising one or more isolated polynucleotides, vectors, and/or vector systems described herein. In some embodiments, an isolated host cell of the present disclosure is cultured in vitro. In some embodiments, the host cell is a bacterial cell (e.g., an  E. coli  cell). In some embodiments, the host cell is a yeast cell (e.g., an  S. cerevisiae  cell). In some embodiments, the host cell is an insect cell. Examples of insect host cells may include, for example,  Drosophila  cells (e.g., S2 cells),  Trichoplusia ni  cells (e.g., High Five™ cells), and  Spodoptera frugiperda  cells (e.g., Sf21 or Sf9 cells). In some embodiments, the host cell is a mammalian cell. Examples of mammalian host cells may include, for example, human embryonic kidney cells (e.g., 293 or 293 cells subcloned for growth in suspension culture), Expi293™ cells, CHO cells, baby hamster kidney cells (e.g., BHK, ATCC CCL 10), mouse sertoli cells (e.g., TM4 cells), monkey kidney cells (e.g., CV1 ATCC CCL 70), African green monkey kidney cells (e.g., VERO-76, ATCC CRL-1587), human cervical carcinoma cells (e.g., HELA, ATCC CCL 2), canine kidney cells (e.g., MDCK, ATCC CCL 34), buffalo rat liver cells (e.g., BRL 3A, ATCC CRL 1442), human lung cells (e.g., W138, ATCC CCL 75), human liver cells (e.g., Hep G2, HB 8065), mouse mammary tumor cells (e.g., MMT 060562, ATCC CCL51), TRI cells, MRC 5 cells, FS4 cells, a human hepatoma line (e.g., Hep G2), and myeloma cells (e.g., NSO and Sp2/0 cells). 
     Other aspects of the present disclosure relate to a method of producing any of the binding proteins described herein. In some embodiments, the method includes a) culturing a host cell (e.g., any of the host cells described herein) comprising an isolated nucleic acid, vector, and/or vector system (e.g., any of the isolated nucleic acids, vectors, and/or vector systems described herein) under conditions such that the host cell expresses the binding protein; and b) isolating the binding protein from the host cell. Methods of culturing host cells under conditions to express a protein are well known to one of ordinary skill in the art. Methods of isolating proteins from cultured host cells are well known to one of ordinary skill in the art, including, for example, by affinity chromatography (e.g., two step affinity chromatography comprising protein A affinity chromatography followed by size exclusion chromatography). 
     Use for Binding Proteins 
     The binding proteins can be employed in any known assay method, such as competitive binding assays, direct and indirect sandwich assays, and immunoprecipitation assays for the detection and quantitation of one or more target antigens. The binding proteins will bind the one or more target antigens with an affinity that is appropriate for the assay method being employed. 
     For diagnostic applications, in certain embodiments, binding proteins can be labeled with a detectable moiety. The detectable moiety can be any one that is capable of producing, either directly or indirectly, a detectable signal. For example, the detectable moiety can be a radioisotope, such as  3 H,  14 C,  32 P,  35 S,  125 I,  99 Tc,  111 In, or  67 Ga; a fluorescent or chemiluminescent compound, such as fluorescein isothiocyanate, rhodamine, or luciferin; or an enzyme, such as alkaline phosphatase, β-galactosidase, or horseradish peroxidase. 
     The binding proteins are also useful for in vivo imaging. A binding protein labeled with a detectable moiety can be administered to an animal, e.g., into the bloodstream, and the presence and location of the labeled antibody in the host assayed. The binding protein can be labeled with any moiety that is detectable in an animal, whether by nuclear magnetic resonance, radiology, or other detection means known in the art. 
     The disclosure also relates to a kit comprising a binding protein and other reagents useful for detecting target antigen levels in biological samples. Such reagents can include a detectable label, blocking serum, positive and negative control samples, and detection reagents. In some embodiments, the kit comprises a composition comprising any binding protein, polynucleotide, vector, vector system, and/or host cell described herein. In some embodiments, the kit comprises a container and a label or package insert on or associated with the container. Suitable containers include, for example, bottles, vials, syringes, IV solution bags, etc. The containers may be formed from a variety of materials such as glass or plastic. The container holds a composition which is by itself or combined with another composition effective for treating, preventing and/or diagnosing a condition (e.g., HIV infection) and may have a sterile access port (for example the container may be an intravenous solution bag or a vial having a stopper pierceable by a hypodermic injection needle). In some embodiments, the label or package insert indicates that the composition is used for preventing, diagnosing, and/or treating the condition of choice. Alternatively, or additionally, the article of manufacture or kit may further comprise a second (or third) container comprising a pharmaceutically-acceptable buffer, such as bacteriostatic water for injection (BWFI), phosphate-buffered saline, Ringer&#39;s solution and dextrose solution. It may further include other materials desirable from a commercial and user standpoint, including other buffers, diluents, filters, needles, and syringes. 
     Therapeutic or pharmaceutical compositions comprising binding proteins are within the scope of the disclosure. Such therapeutic or pharmaceutical compositions can comprise a therapeutically effective amount of a binding protein, or binding protein-drug conjugate, in admixture with a pharmaceutically or physiologically acceptable formulation agent selected for suitability with the mode of administration. 
     Acceptable formulation materials are nontoxic to recipients at the dosages and concentrations employed. 
     The pharmaceutical composition can contain formulation materials for modifying, maintaining, or preserving, for example, the pH, osmolarity, viscosity, clarity, color, isotonicity, odor, sterility, stability, rate of dissolution or release, adsorption, or penetration of the composition. Suitable formulation materials include, but are not limited to, amino acids (such as glycine, glutamine, asparagine, arginine, or lysine), antimicrobials, antioxidants (such as ascorbic acid, sodium sulfite, or sodium hydrogen-sulfite), buffers (such as borate, bicarbonate, Tris-HCl, citrates, phosphates, or other organic acids), bulking agents (such as mannitol or glycine), chelating agents (such as ethylenediamine tetraacetic acid (EDTA)), complexing agents (such as caffeine, polyvinylpyrrolidone, beta-cyclodextrin, or hydroxypropyl-beta-cyclodextrin), fillers, monosaccharides, disaccharides, and other carbohydrates (such as glucose, mannose, or dextrins), proteins (such as serum albumin, gelatin, or immunoglobulins), coloring, flavoring and diluting agents, emulsifying agents, hydrophilic polymers (such as polyvinylpyrrolidone), low molecular weight polypeptides, salt-forming counterions (such as sodium), preservatives (such as benzalkonium chloride, benzoic acid, salicylic acid, thimerosal, phenethyl alcohol, methylparaben, propylparaben, chlorhexidine, sorbic acid, or hydrogen peroxide), solvents (such as glycerin, propylene glycol, or polyethylene glycol), sugar alcohols (such as mannitol or sorbitol), suspending agents, surfactants or wetting agents (such as pluronics; PEG; sorbitan esters; polysorbates such as polysorbate 20 or polysorbate 80; triton; tromethamine; lecithin; cholesterol or tyloxapal), stability enhancing agents (such as sucrose or sorbitol), tonicity enhancing agents (such as alkali metal halides—e.g., sodium or potassium chloride—or mannitol sorbitol), delivery vehicles, diluents, excipients and/or pharmaceutical adjuvants (see, e.g., R EMINGTON&#39;S  P HARMACEUTICAL  S CIENCES  (18th Ed., A. R. Gennaro, ed., Mack Publishing Company 1990), and subsequent editions of the same, incorporated herein by reference for any purpose). 
     The optimal pharmaceutical composition will be determined by a skilled artisan depending upon, for example, the intended route of administration, delivery format, and desired dosage. Such compositions can influence the physical state, stability, rate of in vivo release, and rate of in vivo clearance of the binding protein. 
     The primary vehicle or carrier in a pharmaceutical composition can be either aqueous or non-aqueous in nature. For example, a suitable vehicle or carrier for injection can be water, physiological saline solution, or artificial cerebrospinal fluid, possibly supplemented with other materials common in compositions for parenteral administration. Neutral buffered saline or saline mixed with serum albumin are further exemplary vehicles. Other exemplary pharmaceutical compositions comprise Tris buffer of about pH 7.0-8.5, or acetate buffer of about pH 4.0-5.5, which can further include sorbitol or a suitable substitute. In one embodiment of the disclosure, binding protein compositions can be prepared for storage by mixing the selected composition having the desired degree of purity with optional formulation agents in the form of a lyophilized cake or an aqueous solution. Further, the binding protein can be formulated as a lyophilizate using appropriate excipients such as sucrose. 
     The pharmaceutical compositions of the disclosure can be selected for parenteral delivery or subcutaneous. Alternatively, the compositions can be selected for inhalation or for delivery through the digestive tract, such as orally. The preparation of such pharmaceutically acceptable compositions is within the skill of the art. 
     The formulation components are present in concentrations that are acceptable to the site of administration. For example, buffers are used to maintain the composition at physiological pH or at a slightly lower pH, typically within a pH range of from about 5 to about 8. 
     When parenteral administration is contemplated, the therapeutic compositions for use can be in the form of a pyrogen-free, parenterally acceptable, aqueous solution comprising the desired binding protein in a pharmaceutically acceptable vehicle. A particularly suitable vehicle for parenteral injection is sterile distilled water in which a binding protein is formulated as a sterile, isotonic solution, properly preserved. Yet another preparation can involve the formulation of the desired molecule with an agent, such as injectable microspheres, bio-erodible particles, polymeric compounds (such as polylactic acid or polyglycolic acid), beads, or liposomes, that provides for the controlled or sustained release of the product which can then be delivered via a depot injection. Hyaluronic acid can also be used, and this can have the effect of promoting sustained duration in the circulation. Other suitable means for the introduction of the desired molecule include implantable drug delivery devices. 
     In one embodiment, a pharmaceutical composition can be formulated for inhalation. For example, a binding protein can be formulated as a dry powder for inhalation. Binding protein inhalation solutions can also be formulated with a propellant for aerosol delivery. In yet another embodiment, solutions can be nebulized. 
     It is also contemplated that certain formulations can be administered orally. In one embodiment of the disclosure, binding proteins that are administered in this fashion can be formulated with or without those carriers customarily used in the compounding of solid dosage forms such as tablets and capsules. For example, a capsule can be designed to release the active portion of the formulation at the point in the gastrointestinal tract where bioavailability is maximized and pre-systemic degradation is minimized. Additional agents can be included to facilitate absorption of the binding protein. Diluents, flavorings, low melting point waxes, vegetable oils, lubricants, suspending agents, tablet disintegrating agents, and binders can also be employed. 
     Another pharmaceutical composition can involve an effective quantity of binding proteins in a mixture with non-toxic excipients that are suitable for the manufacture of tablets. By dissolving the tablets in sterile water, or another appropriate vehicle, solutions can be prepared in unit-dose form. Suitable excipients include, but are not limited to, inert diluents, such as calcium carbonate, sodium carbonate or bicarbonate, lactose, or calcium phosphate; or binding agents, such as starch, gelatin, or acacia; or lubricating agents such as magnesium stearate, stearic acid, or talc. 
     Additional pharmaceutical compositions of the disclosure will be evident to those skilled in the art, including formulations involving binding proteins in sustained- or controlled-delivery formulations. Techniques for formulating a variety of other sustained- or controlled-delivery means, such as liposome carriers, bio-erodible microparticles or porous beads and depot injections, are also known to those skilled in the art. Additional examples of sustained-release preparations include semipermeable polymer matrices in the form of shaped articles, e.g. films, or microcapsules. Sustained release matrices can include polyesters, hydrogels, polylactides, copolymers of L-glutamic acid and gamma ethyl-L-glutamate, poly(2-hydroxyethyl-methacrylate), ethylene vinyl acetate, or poly-D(−)-3-hydroxybutyric acid. Sustained-release compositions can also include liposomes, which can be prepared by any of several methods known in the art. 
     Pharmaceutical compositions to be used for in vivo administration typically must be sterile. This can be accomplished by filtration through sterile filtration membranes. Where the composition is lyophilized, sterilization using this method can be conducted either prior to, or following, lyophilization and reconstitution. The composition for parenteral administration can be stored in lyophilized form or in a solution. In addition, parenteral compositions generally are placed into a container having a sterile access port, for example, an intravenous solution bag or vial having a stopper pierceable by a hypodermic injection needle. 
     Once the pharmaceutical composition has been formulated, it can be stored in sterile vials as a solution, suspension, gel, emulsion, solid, or as a dehydrated or lyophilized powder. Such formulations can be stored either in a ready-to-use form or in a form (e.g., lyophilized) requiring reconstitution prior to administration. 
     The disclosure also encompasses kits for producing a single-dose administration unit. The kits can each contain both a first container having a dried protein and a second container having an aqueous formulation. Also included within the scope of this disclosure are kits containing single and multi-chambered pre-filled syringes (e.g., liquid syringes and lyosyringes). 
     The effective amount of a binding protein pharmaceutical composition to be employed therapeutically will depend, for example, upon the therapeutic context and objectives. One skilled in the art will appreciate that the appropriate dosage levels for treatment will thus vary depending, in part, upon the molecule delivered, the indication for which the binding protein is being used, the route of administration, and the size (body weight, body surface, or organ size) and condition (the age and general health) of the patient. Accordingly, the clinician can titer the dosage and modify the route of administration to obtain the optimal therapeutic effect. 
     Dosing frequency will depend upon the pharmacokinetic parameters of the binding protein in the formulation being used. Typically, a clinician will administer the composition until a dosage is reached that achieves the desired effect. The composition can therefore be administered as a single dose, as two or more doses (which may or may not contain the same amount of the desired molecule) over time, or as a continuous infusion via an implantation device or catheter. Further refinement of the appropriate dosage is routinely made by those of ordinary skill in the art and is within the ambit of tasks routinely performed by them. Appropriate dosages can be ascertained through use of appropriate dose-response data. 
     The route of administration of the pharmaceutical composition is in accord with known methods, e.g., orally; through injection by intravenous, intraperitoneal, intracerebral (intraparenchymal), intracerebroventricular, intramuscular, intraocular, intraarterial, intraportal, or intralesional routes; by sustained release systems; or by implantation devices. Where desired, the compositions can be administered by bolus injection or continuously by infusion, or by implantation device. 
     The composition can also be administered locally via implantation of a membrane, sponge, or other appropriate material onto which the desired molecule has been absorbed or encapsulated. Where an implantation device is used, the device can be implanted into any suitable tissue or organ, and delivery of the desired molecule can be via diffusion, timed-release bolus, or continuous administration. 
     The pharmaceutical compositions can be used to prevent and/or treat HIV infection. The pharmaceutical compositions can be used as a standalone therapy or in combination with standard anti-retroviral therapy. 
     In some embodiments, the present disclosure relates to a method of preventing and/or treating HIV infection in a patient. In some embodiments, the method comprises administering to the patient a therapeutically effective amount of at least one of the binding proteins described herein. In some embodiments, the at least one binding protein is administered in combination with an anti-retroviral therapy (e.g., an anti-HIV therepy). In some embodiments, the at least one binding protein is administered before the anti-retroviral therapy. In some embodiments, the at least one binding protein is administered concurrently with the anti-retroviral therapy. In some embodiments, the at least one binding protein is administered after the anti-retroviral therapy. In some embodiments, the at least one binding protein is co-administered with any standard anti-retroviral therapy known in the art. In some embodiments, administration of the at least one binding protein results in neutralization of one or more HIV virions. In some embodiments, administration of the at least one binding protein results in elimination of one or more latently and/or chronically HIV-infected cells in the patient. In some embodiments, administration of the at least one binding protein results in neutralization of one or more HIV virions and results in elimination of one or more latently and/or chronically HIV-infected cells in the patient. In some embodiments, the patient is a human. 
     Without limiting the present disclosure, a number of embodiments of the present disclosure are described below for purpose of illustration. 
     Item 1: A binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II]
 
     and a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1   [III]
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     Item 2: A binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1 -hinge-C H2 -C H3   [II]
 
     and a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1 -hinge-C H2 -C H3   [III]
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is an immunoglobulin C H1  heavy chain constant domain;
 
C H2  is an immunoglobulin C H2  heavy chain constant domain;
 
C H3  is an immunoglobulin C H3  heavy chain constant domain; hinge is an immunoglobulin hinge region connecting the C H1  and C H2  domains; and
 
L 1 , L 2 , L 3  and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     Item 3: The binding protein of item 1 or item 2, wherein the one or more HIV target proteins is selected from the group consisting of glycoprotein 120, glycoprotein 41 and glycoprotein 60. 
     Item 4: The binding protein of item 1 or item 2, wherein the binding protein is trispecific and capable of specifically binding three different epitopes on a single HIV target protein. 
     Item 5: The binding protein of item 1 or item 2, wherein the binding protein is trispecific and capable of specifically binding two different epitopes on a first HIV target protein, and one epitope on a second HIV target protein, wherein the first and second HIV target proteins are different. 
     Item 6: The binding protein of item 1 or item 2, wherein the binding protein is trispecific and capable of specifically binding three different antigen targets. 
     Item 7: The binding protein of item 1 or item 2, wherein the binding protein is capable of inhibiting the function of one or more HIV target proteins. 
     Item 8: The binding protein of any one of items 1-7, wherein V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; or a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively. 
     Item 9: The binding protein of any one of items 1-7, wherein V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. 
     Item 10: The binding protein of any one of items 1-9, wherein V L1  comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. 
     Item 11: The binding protein of any one of items 1-10, wherein V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; or a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively. 
     Item 12: The binding protein of any one of items 1-10, wherein V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. 
     Item 13: The binding protein of any one of items 1-12, wherein V L2  comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. 
     Item 14: The binding protein of any one of items 1-13, wherein V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; or a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively. 
     Item 15: The binding protein of any one of items 1-13, wherein V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. 
     Item 16: The binding protein of any one of items 1-15, wherein V L3  comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. 
     Item 17: The binding protein of any one of items 1-16, wherein V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; or a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively. 
     Item 18: The binding protein of any one of items 1-16, wherein V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. 
     Item 19: The binding protein of any one of items 1-18, wherein V H1  comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. 
     Item 20: The binding protein of any one of items 1-19, wherein V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; or a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively. 
     Item 21: The binding protein of any one of items 1-19, wherein V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. 
     Item 22: The binding protein of any one of items 1-21, wherein V H2  comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. 
     Item 23: The binding protein of any one of items 1-22, wherein V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; or a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively. 
     Item 24: The binding protein of any one of items 1-22, wherein V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. 
     Item 25: The binding protein of any one of items 1-24, wherein V H3  comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. 
     Item 26: The binding protein of any one of items 1-25, wherein V L1  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 500, a CDR-L2 comprising the sequence of SEQ ID NO: 501, and a CDR-L3 comprising the sequence of SEQ ID NO: 274; V L2  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 275, a CDR-L2 comprising the sequence of SEQ ID NO: 276, and a CDR-L3 comprising the sequence of SEQ ID NO: 277; V L3  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 266, a CDR-L2 comprising the sequence of SEQ ID NO: 267, and a CDR-L3 comprising the sequence of SEQ ID NO: 268; V H1  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 254, a CDR-H2 comprising the sequence of SEQ ID NO: 255, and a CDR-H3 comprising the sequence of SEQ ID NO: 256; V H2  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 257, a CDR-H2 comprising the sequence of SEQ ID NO: 258, and a CDR-H3 comprising the sequence of SEQ ID NO: 259; and V H3  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 248, a CDR-H2 comprising the sequence of SEQ ID NO: 497, and a CDR-H3 comprising the sequence of SEQ ID NO: 250. 
     Item 27: The binding protein of any one of items 1-25, wherein V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 518; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 519; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 512; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 504; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 506; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 502. 
     Item 28: The binding protein of any one of items 1-27, wherein V L1  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 518; V L2  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 519; V L3  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 512; V H1  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 504; V H2  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 506; and V H3  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 502. 
     Item 29: The binding protein of any one of items 1-25, wherein V L1  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 500, a CDR-L2 comprising the sequence of SEQ ID NO: 501, and a CDR-L3 comprising the sequence of SEQ ID NO: 274; V L2  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 275, a CDR-L2 comprising the sequence of SEQ ID NO: 276, and a CDR-L3 comprising the sequence of SEQ ID NO: 277; V L3  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 269, a CDR-L2 comprising the sequence of SEQ ID NO: 270, and a CDR-L3 comprising the sequence of SEQ ID NO: 271; V H1  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 254, a CDR-H2 comprising the sequence of SEQ ID NO: 255, and a CDR-H3 comprising the sequence of SEQ ID NO: 256; V H2  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 257, a CDR-H2 comprising the sequence of SEQ ID NO: 258, and a CDR-H3 comprising the sequence of SEQ ID NO: 259; and V H3  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 251, a CDR-H2 comprising the sequence of SEQ ID NO: 252, and a CDR-H3 comprising the sequence of SEQ ID NO: 253. 
     Item 30: The binding protein of any one of items 1-25, wherein V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 518; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 519; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 513; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 504; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 506; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 503. 
     Item 31: The binding protein of any one of items 1-25 and 29-30, wherein V L1  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 518; V L2  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 519; V L3  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 513; V H1  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 504; V H2  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 506; and 
     V H3  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 503. 
     Item 32: The binding protein of any one of items 1-25, wherein V L1  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 275, a CDR-L2 comprising the sequence of SEQ ID NO: 276, and a CDR-L3 comprising the sequence of SEQ ID NO: 277; V L2  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 500, a CDR-L2 comprising the sequence of SEQ ID NO: 501, and a CDR-L3 comprising the sequence of SEQ ID NO: 274; V L3  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 269, a CDR-L2 comprising the sequence of SEQ ID NO: 270, and a CDR-L3 comprising the sequence of SEQ ID NO: 271; V H1  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 257, a CDR-H2 comprising the sequence of SEQ ID NO: 258, and a CDR-H3 comprising the sequence of SEQ ID NO: 259; V H2  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 254, a CDR-H2 comprising the sequence of SEQ ID NO: 255, and a CDR-H3 comprising the sequence of SEQ ID NO: 256; and V H3  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 251, a CDR-H2 comprising the sequence of SEQ ID NO: 252, and a CDR-H3 comprising the sequence of SEQ ID NO: 253. 
     Item 33: The binding protein of any one of items 1-25, wherein V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 519; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 518; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 513; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 506; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 504; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 503. 
     Item 34: The binding protein of any one of items 1-25 and 32-33, wherein V L1  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 519; V L2  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 518; V L3  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 513; V H1  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 506; V H2  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 504; and 
     V H3  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 503. 
     Item 35: The binding protein of item 1, wherein the second polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. 
     Item 36: The binding protein of item 1, wherein the third polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. 
     Item 37: The binding protein of item 1, wherein the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. 
     Item 38: The binding protein of item 1, wherein the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. 
     Item 39: The binding protein of any one of items 1, 37, and 38, wherein the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains; wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     Item 40: The binding protein of item 2, wherein the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. 
     Item 41: The binding protein of item 2, wherein the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. 
     Item 42: The binding protein of any one of items 2, 40, and 41, wherein the C H3  domains of the second and the third polypeptide chains both comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     Item 43: The binding protein of item 1 or item 2, wherein at least one of L 1 , L 2 , L 3 , or L 4  is independently 0 amino acids in length. 
     Item 44: The binding protein of item 1 or item 2, wherein L 1 , L 2 , L 3 , or L 4  are each independently at least one amino acid in length. 
     Item 45: The binding protein of any one of items 1-44, wherein L 1  comprises Asp-Lys-Thr-His-Thr (SEQ ID NO: 525). 
     Item 46: A binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II]
 
     and a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1   [III]
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair;
 
wherein:
 
     (a) V L1 , V L2  and V L3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 2, 4, 10, 12, 18, 20, 26, 28, 34, 36, 42, 44, 50, 52, 58, 60, 66, 68, 74, 76, 82, 84, 90, 92, 98, 100, 106, 108, 114, 116, 122, 124, 130, 132, 138, 140, 146, 148, 154, 156, 162, 164, 170, 172, 178, 180, 186, 188, 194, 196, 202, 204, 210,212, 218, 220, 226, 228, 233, 235, 241, 243; or 
     (b) V L1 , V L2  and V L3  each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs:266-283; and 
     wherein: 
     (a) V H1 , V H2 , and V H3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 1, 3, 9, 11, 17, 10, 25, 27, 33, 35, 41, 43, 49, 51, 57, 59, 65, 67, 73, 75, 81, 83, 89, 91, 97, 99, 105, 107, 113, 115, 121, 123, 129, 131, 137, 139, 145, 147, 153, 155, 161, 163, 169, 171, 177, 179, 185, 187, 193, 195, 201, 203, 209, 211, 217, 219, 225, 227, 232, 234, 240, 242; or 
     (b) V H1 , V H2 , and V H3  each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-265. 
     Item 47: A binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1 -hinge-C H2 -C H3   [II]
 
     and a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1 -hinge-C H2 -C H3   [III]
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain;
 
C H2  is an immunoglobulin C H2  heavy chain constant domain;
 
C H3  is an immunoglobulin C H3  heavy chain constant domain; hinge is an immunoglobulin hinge region connecting the C H1  and C H2  domains; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair;
 
wherein:
 
     (a) V L1 , V L2  and V L3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 2, 4, 10, 12, 18, 20, 26, 28, 34, 36, 42, 44, 50, 52, 58, 60, 66, 68, 74, 76, 82, 84, 90, 92, 98, 100, 106, 108, 114, 116, 122, 124, 130, 132, 138, 140, 146, 148, 154, 156, 162, 164, 170, 172, 178, 180, 186, 188, 194, 196, 202, 204, 210,212, 218, 220, 226, 228, 233, 235, 241, 243; or 
     (b) V L1 , V L2  and V L3  each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs:266-283; and 
     wherein: 
     (a) V H1 , V H2 , and V H3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 1, 3, 9, 11, 17, 10, 25, 27, 33, 35, 41, 43, 49, 51, 57, 59, 65, 67, 73, 75, 81, 83, 89, 91, 97, 99, 105, 107, 113, 115, 121, 123, 129, 131, 137, 139, 145, 147, 153, 155, 161, 163, 169, 171, 177, 179, 185, 187, 193, 195, 201, 203, 209, 211, 217, 219, 225, 227, 232, 234, 240, 242; or 
     (b) V H1 , V H2 , and V H3  each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-265. 
     Item 48: The binding protein of item 46, wherein the second polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. 
     Item 49: The binding protein of item 46, wherein the third polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. 
     Item 50: The binding protein of item 46, wherein the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. 
     Item 51: The binding protein of item 46, wherein the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. 
     Item 52: The binding protein of any one of items 46, 50, and 51, wherein the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains; wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     Item 53: The binding protein of item 47, wherein the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. 
     Item 54: The binding protein of item 47, wherein the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. 
     Item 55: The binding protein of any one of items 47, 53, and 54, wherein the C H3  domains of the second and the third polypeptide chains both comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     Item 56: The binding protein of item 46 or item 47, wherein at least one of L 1 , L 2 , L 3  or L 4  is independently 0 amino acids in length. 
     Item 57: The binding protein of item 46 or item 47, wherein L 1 , L 2 , L 3  or L 4  are each independently at least one amino acid in length. 
     Item 58: The binding protein of any one of items 46-57, wherein L 1  comprises Asp-Lys-Thr-His-Thr (SEQ ID NO: 525). 
     Item 59: A binding protein comprising a first polypeptide chain, a second polypeptide chain, a third polypeptide chain and a fourth polypeptide chain wherein: 
     (a) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 4 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 4; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 3; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 1; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 2; 
     (b) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 12 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 12; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 11 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 11; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 9 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 9; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 10 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 10; 
     (c) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 20 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 20; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 19 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 19; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 17 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 17; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 18 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 18; 
     (d) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 28 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 28; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 27 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 27; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 25 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 25; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 26 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 26; 
     (e) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 36; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 35 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 35; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 33 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 33; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 34 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 34; 
     (f) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 44 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 44; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 43 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 43; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 41 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 41; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 42 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 42; 
     (g) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 52 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 52; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 51 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 51; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 49 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 49; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 50 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 50; 
     (h) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 60 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 60; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 59 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 59; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 57 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 57; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 58 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 58; 
     (i) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 68 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 68; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 67 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 67; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 65 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 65; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 66 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 66; 
     (j) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 76 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 76; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 75 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 75; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 73 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 73; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 74 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 74; 
     (k) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 84 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 84; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 83 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 83; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 81 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 81; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 82 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 82; 
     (l) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 92 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:92; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 91 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 91; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 89 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 89; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 90 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 90; 
     (m) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 100 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 100; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 99 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 99; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 97 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 97; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 98 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 98; 
     (n) the first polypeptide comprises the amino acid sequence of SEQ ID NO: 108 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 108; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 107 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 107; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 105 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 105; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 106 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 106; 
     (o) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 116 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 116; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 115 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 115; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 113 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 113; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 114 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 114; 
     (p) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 124 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 124; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 123 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 123; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 121 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 121; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 122 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 122; 
     (q) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 132 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 132; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 131 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 131; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 129 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 129; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 130 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 130; 
     (r) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 140 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 140; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 139 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 139; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 137 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 137; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 138 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 138; 
     (s) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 148 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 148; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 147 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 147; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 145 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 145; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 146 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 146; 
     (t) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 156 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 156; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 155 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 155; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 153 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 153; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 154 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 154; 
     (u) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 164 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 164; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 163 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 163; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 161 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 161; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 162 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 162; 
     (v) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 172 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 172; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 171 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 171; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 169 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 169; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 170 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 170; 
     (w) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 180 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 180; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 179 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 179; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 177 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 177; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 178 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 178; 
     (x) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 188 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 188; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 187 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 187; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 185 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 185; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 186 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 186; 
     (y) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 196 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 196; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 195 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 195; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 193 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 193; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 194 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 194; 
     (z) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 204 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 204; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 203 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 203; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 201 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 201; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 202 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 202; 
     (aa) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 212 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 212; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 211 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 211; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 209 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 209; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 210 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 210; 
     (bb) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 220 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 220; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 219 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 219; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 217 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 217; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 218 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 218; 
     (cc) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 228 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 228; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 227 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 227; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 225 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 225; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 226 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 226; 
     (dd) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 235 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 235; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 234 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 234; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 232 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 232; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 233 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 233; or 
     (ee) first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 243 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 243; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 242 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 242; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 240 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 240; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 241 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 241. 
     Item 60: A binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins and one or more T cell target proteins, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II]
 
     a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1   [III];
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV];
 
     wherein
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     Item 61: A binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins and one or more T cell target proteins, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I];
 
     a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1 -hinge-C H2 -C H3   [II];
 
     a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1 -hinge-C H2 -C H3   [III];
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV];
 
     wherein
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain;
 
C H2  is an immunoglobulin C H2  heavy chain constant domain;
 
C H3  is an immunoglobulin C H3  heavy chain constant domain; hinge is an immunoglobulin hinge region connecting the C H1  and C H2  domains; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
 
     Item 62: The binding protein of item 60 or item 61, wherein the one or more HIV target proteins are selected from the group consisting of glycoprotein 120, glycoprotein 41 and glycoprotein 160. 
     Item 63: The binding protein of item 60 or item 61, wherein the one or more T cell target proteins are CD3 or CD28. 
     Item 64: The binding protein of item 60 or item 61, wherein the binding protein is trispecific and capable of specifically binding an HIV target protein and two different epitopes on a single T cell target protein. 
     Item 65: The binding protein of item 60 or item 61, wherein the binding protein is trispecific and capable of specifically binding an HIV target protein and two different T cell target proteins. 
     Item 66: The binding protein of item 60 or item 61, wherein the binding protein is trispecific and capable of specifically binding a T cell target protein and two different epitopes on a single HIV target protein. 
     Item 67: The binding protein of item 60 or item 61, wherein the binding protein is trispecific and capable of specifically binding a T cell target protein and two different HIV target proteins. 
     Item 68: The binding protein of item 60 or item 61, wherein the first and second polypeptide chains form two antigen binding sites that specifically target two T cell target proteins, and the third and fourth polypeptide chains form an antigen binding site that specifically binds an HIV target protein. 
     Item 69: The binding protein of any one of items 60-68, wherein V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively; a sequence as set forth in SEQ ID NOs: 488, 489, and 490, respectively; a sequence as set forth in SEQ ID NOs: 491, 492, and 493, respectively; or a sequence as set forth in SEQ ID NOs: 494, 495, and 496, respectively. 
     Item 70: The binding protein of any one of items 60-68, wherein V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. 
     Item 71: The binding protein of any one of items 60-70, wherein V L1  comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. 
     Item 72: The binding protein of any one of items 60-71, wherein V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively; a sequence as set forth in SEQ ID NOs: 488, 489, and 490, respectively; a sequence as set forth in SEQ ID NOs: 491, 492, and 493, respectively; or a sequence as set forth in SEQ ID NOs: 494, 495, and 496, respectively. 
     Item 73: The binding protein of any one of items 60-71, wherein V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. 
     Item 74: The binding protein of any one of items 60-73, wherein V L2  comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. 
     Item 75: The binding protein of any one of items 60-74, wherein V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NOs: 269, 270, and 271, respectively; a sequence as set forth in SEQ ID NOs: 500, 501, and 274, respectively; a sequence as set forth in SEQ ID NOs: 275, 276, and 277, respectively; a sequence as set forth in SEQ ID NOs: 281, 282, and 283, respectively; a sequence as set forth in SEQ ID NOs: 278, 279, and 280, respectively; a sequence as set forth in SEQ ID NOs: 488, 489, and 490, respectively; a sequence as set forth in SEQ ID NOs: 491, 492, and 493, respectively; or a sequence as set forth in SEQ ID NOs: 494, 495, and 496, respectively. 
     Item 76: The binding protein of any one of items 60-74, wherein V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. 
     Item 77: The binding protein of any one of items 60-76, wherein V L3  comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. 
     Item 78: The binding protein of any one of items 60-77, wherein V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively; a sequence as set forth in SEQ ID NOs: 479, 480, and 481, respectively; a sequence as set forth in SEQ ID NOs: 482, 483, and 484, respectively; or a sequence as set forth in SEQ ID NOs: 485, 486, and 487, respectively. 
     Item 79: The binding protein of any one of items 60-77, wherein V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. 
     Item 80: The binding protein of any one of items 60-79, wherein V H1  comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. 
     Item 81: The binding protein of any one of items 60-80, wherein V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively; a sequence as set forth in SEQ ID NOs: 479, 480, and 481, respectively; a sequence as set forth in SEQ ID NOs: 482, 483, and 484, respectively; or a sequence as set forth in SEQ ID NOs: 485, 486, and 487, respectively. 
     Item 82: The binding protein of any one of items 60-80, wherein V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. 
     Item 83: The binding protein of any one of items 60-82, wherein V H2  comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. 
     Item 84: The binding protein of any one of items 60-83, wherein V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively; a sequence as set forth in SEQ ID NOs: 479, 480, and 481, respectively; a sequence as set forth in SEQ ID NOs: 482, 483, and 484, respectively; or a sequence as set forth in SEQ ID NOs: 485, 486, and 487, respectively. 
     Item 85: The binding protein of any one of items 60-83, wherein V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. 
     Item 86: The binding protein of any one of items 60-85, wherein V H3  comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. 
     Item 87: The binding protein of any one of items 60-86, wherein V L1  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 488, a CDR-L2 comprising the sequence of SEQ ID NO: 489, and a CDR-L3 comprising the sequence of SEQ ID NO: 490; V L2  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 494, a CDR-L2 comprising the sequence of SEQ ID NO: 495, and a CDR-L3 comprising the sequence of SEQ ID NO: 496; V L3  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 269, a CDR-L2 comprising the sequence of SEQ ID NO: 270, and a CDR-L3 comprising the sequence of SEQ ID NO: 271; V H1  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 479, a CDR-H2 comprising the sequence of SEQ ID NO: 480, and a CDR-H3 comprising the sequence of SEQ ID NO: 481; V H2  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 485, a CDR-H2 comprising the sequence of SEQ ID NO: 486, and a CDR-H3 comprising the sequence of SEQ ID NO: 487; and V H3  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 251, a CDR-H2 comprising the sequence of SEQ ID NO: 252, and a CDR-H3 comprising the sequence of SEQ ID NO: 253. 
     Item 88: The binding protein of any one of items 60-86, wherein V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 522; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 524; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 513; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 509; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 511; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 503. 
     Item 89: The binding protein of any one of items 60-88, wherein V L1  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 522; V L2  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 524; V L3  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 513; V H1  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 509; V H2  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 511; and V H3  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 503. 
     Item 90: The binding protein of any one of items 60-86, wherein V L1  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 494, a CDR-L2 comprising the sequence of SEQ ID NO: 495, and a CDR-L3 comprising the sequence of SEQ ID NO: 496; V L2  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 488, a CDR-L2 comprising the sequence of SEQ ID NO: 489, and a CDR-L3 comprising the sequence of SEQ ID NO: 490; V L3  comprises a CDR-L1 comprising the sequence of SEQ ID NO: 269, a CDR-L2 comprising the sequence of SEQ ID NO: 270, and a CDR-L3 comprising the sequence of SEQ ID NO: 271; V H1  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 485, a CDR-H2 comprising the sequence of SEQ ID NO: 486, and a CDR-H3 comprising the sequence of SEQ ID NO: 487; V H2  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 479, a CDR-H2 comprising the sequence of SEQ ID NO: 480, and a CDR-H3 comprising the sequence of SEQ ID NO: 481; and V H3  comprises a CDR-H1 comprising the sequence of SEQ ID NO: 251, a CDR-H2 comprising the sequence of SEQ ID NO: 252, and a CDR-H3 comprising the sequence of SEQ ID NO: 253. 
     Item 91: The binding protein of any one of items 60-86, wherein V L1  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 524; V L2  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 522; V L3  comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 513; V H1  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 511; V H2  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 509; and V H3  comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 503. 
     Item 92: The binding protein of any one of items 60-86 and 90-91, wherein V L1  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 524; V L2  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 522; V L3  comprises a light chain variable domain comprising the sequence of SEQ ID NO: 513; V H1  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 511; V H2  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 509; and 
     V H3  comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 503. 
     Item 93: The binding protein of item 60, wherein the second polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. 
     Item 94: The binding protein of item 60, wherein the third polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. 
     Item 95: The binding protein of item 60, wherein the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. 
     Item 96: The binding protein of item 60, wherein the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. 
     Item 97: The binding protein of any one of items 60, 95, and 96, wherein the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains; wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     Item 98: The binding protein of item 61, wherein the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. 
     Item 99: The binding protein of item 61, wherein the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. 
     Item 100: The binding protein of any one of items 61, 98, and 99, wherein the C H3  domains of the second and the third polypeptide chains both comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     Item 101: The binding protein of item 60 or item 61, wherein at least one of L 1 , L 2 , L 3 , or L 4  is independently 0 amino acids in length. 
     Item 102: The binding protein of item 60 or item 61, wherein L 1 , L 2 , L 3 , or L 4  are each independently at least one amino acid in length. 
     Item 103: The binding protein of any one of items 60-102, wherein L 1  is Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299). 
     Item 104: A binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1   [II]
 
     and a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1   [III]
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair;
 
wherein:
 
     (a) V L1 , V L2  and V L3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 303, 305, 311, 313, 319, 321, 327, 329, 335, 337, 343, 345, 351, 353, 359, 361, 367, 369, 375, 377, 383, 385, 391, 393, 399, 401, 407, 409, 415, 417, 423, 425, 431, 433, 439, 441, 447, 449, 455, 457, 463, 465, 471, 473; or 
     (b) V L1 , V L2  and V L3  each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 266-271, 275-277, 488-496; and 
     wherein: 
     (a) V H1 , V H2 , and V H3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 302, 304, 310, 312, 318, 320, 326, 328, 334, 336, 342, 344, 350, 352, 358, 360, 366, 368, 374, 376, 382, 384, 390, 392, 398, 400, 406, 408, 414, 416, 422, 424, 430, 432, 438, 440, 446, 448, 454, 456, 462, 464, 470, 472; or 
     (b) V H1 , V H2 , and V H3  each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-253, 257-259, 479-487. 
     Item 105: A binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain comprises a structure represented by the formula: 
       V L2 -L 1 -V L1 -L 2 -C L   [I]
 
     and a second polypeptide chain comprises a structure represented by the formula: 
       V H1 -L 3 -V H2 -L 4 -C H1 -hinge-C H2 -C H3   [II]
 
     and a third polypeptide chain comprises a structure represented by the formula: 
       V H3 -C H1 -hinge-C H2 -C H3   [III]
 
     and a fourth polypeptide chain comprises a structure represented by the formula: 
       V L3 -C L   [IV]
 
     wherein:
 
V L1  is a first immunoglobulin light chain variable domain;
 
V L2  is a second immunoglobulin light chain variable domain;
 
V L3  is a third immunoglobulin light chain variable domain;
 
V H1  is a first immunoglobulin heavy chain variable domain;
 
V H2  is a second immunoglobulin heavy chain variable domain;
 
V H3  is a third immunoglobulin heavy chain variable domain;
 
C L  is an immunoglobulin light chain constant domain;
 
C H1  is the immunoglobulin C H1  heavy chain constant domain;
 
C H2  is an immunoglobulin C H2  heavy chain constant domain;
 
C H3  is an immunoglobulin C H3  heavy chain constant domain; hinge is an immunoglobulin hinge region connecting the C H1  and C H2  domains; and
 
L 1 , L 2 , L 3 , and L 4  are amino acid linkers;
 
wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair;
 
wherein:
 
     (a) V L1 , V L2  and V L3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 303, 305, 311, 313, 319, 321, 327, 329, 335, 337, 343, 345, 351, 353, 359, 361, 367, 369, 375, 377, 383, 385, 391, 393, 399, 401, 407, 409, 415, 417, 423, 425, 431, 433, 439, 441, 447, 449, 455, 457, 463, 465, 471, 473; or 
     (b) V L1 , V L2  and V L3  each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 266-271, 275-277, 488-496; and 
     wherein: 
     (a) V H1 , V H2 , and V H3  are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 302, 304, 310, 312, 318, 320, 326, 328, 334, 336, 342, 344, 350, 352, 358, 360, 366, 368, 374, 376, 382, 384, 390, 392, 398, 400, 406, 408, 414, 416, 422, 424, 430, 432, 438, 440, 446, 448, 454, 456, 462, 464, 470, 472; or 
     (b) V H1 , V H2 , and V H3  each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-253, 257-259, 479-487. 
     Item 106: The binding protein of item 104, wherein the second polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. 
     Item 107: The binding protein of item 104, wherein the third polypeptide chain further comprises an Fc region linked to C H1 , the Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains. 
     Item 108: The binding protein of item 104, wherein the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. 
     Item 109: The binding protein of item 104, wherein the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. 
     Item 110: The binding protein of any one of items 104, 108, and 109, wherein the second polypeptide chain further comprises a first Fc region linked to C H1 , the first Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains, and wherein the third polypeptide chain further comprises a second Fc region linked to C H1 , the second Fc region comprising an immunoglobulin hinge region and C H2  and C H3  immunoglobulin heavy chain constant domains; wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     Item 111: The binding protein of item 105, wherein the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. 
     Item 112: The binding protein of item 105, wherein the C H3  domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the C H3  domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W. 
     Item 113: The binding protein of any one of items 105, 111, and 112, wherein the C H3  domains of the second and the third polypeptide chains both comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. 
     Item 114: The binding protein of item 104 or item 105, wherein at least one of L 1 , L 2 , L 3 , or L 4  is independently 0 amino acids in length. 
     Item 115: The binding protein of item 104 or item 105, wherein L 1 , L 2 , L 3 , or L 4  are each independently at least one amino acid in length. 
     Item 116: The binding protein of any one of items 104-115, wherein L 1  is Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299). 
     Item 117: A binding protein comprising a first polypeptide chain, a second polypeptide chain, a third polypeptide chain and a fourth polypeptide chain wherein: 
     (a) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 305 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 305; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 304 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 304; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 302 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 302; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 303 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 303; 
     (b) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 313 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 313; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 312 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 312; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 310 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 310; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 311 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 311; 
     (c) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 321 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 321; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 320 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 320; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 318 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 318; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 319 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 319; 
     (d) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 329 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 329; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 328 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 328; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 326 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 326; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 327 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 327; 
     (e) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 337 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 337; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 336 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 336; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 334 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 334; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 335 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 335; 
     (f) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 345 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 345; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 344 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 344; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 342 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 342; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 343 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 343; 
     (g) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 353 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 353; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 352 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:352; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 350 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 350; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 351 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 351; 
     (h) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 361 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 361; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 360 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 360; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 358 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 358; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 359 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 359; 
     (i) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 369 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 369; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 368 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 368; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 366 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 366; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 367 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 367; 
     (j) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 377 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 377; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 376 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 376; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 374 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 374; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 375 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 375; 
     (k) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 385 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 385; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 384 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 384; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 382 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 382; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 383 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 383; 
     (l) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 393 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 393; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 392 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 392; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 390 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 390; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 391 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 391; 
     (m) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 401 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 401; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 400 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 400; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 398 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 398; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 399 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 399; 
     (n) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 409 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 409; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 408 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 408; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 406 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 406; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 407 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 407; 
     (p) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 417 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 417; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 416 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 416; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 414 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 414; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 415 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 415; 
     (q) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 425 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 425; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 424 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 424; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 422 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 422; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 423 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 423; 
     (r) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 433 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:433; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 432 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 432; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 430 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 430; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 431 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 431; 
     (s) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 441 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 441; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 440 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 440; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 438 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 438; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 439 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 439; 
     (t) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 449 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 449; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 448 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 448; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 446 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 446; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 447 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 447; 
     (u) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 457 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 457; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 456 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 456; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 454 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 454; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 455 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 455; 
     (v) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 465 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 465; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 464 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 464; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 462 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 462; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 463 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 463; or 
     (w) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 473 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 473; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 472 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 472; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 470 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 470; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 471 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 471. 
     Item 118: An isolated nucleic acid molecule comprising a nucleotide sequence encoding the binding protein of any one of items 1-117. 
     Item 119: An expression vector comprising the nucleic acid molecule of item 118. 
     Item 120: An isolated host cell comprising the nucleic acid molecule of item 118. 
     Item 121: An isolated host cell comprising the expression vector of item 119. 
     Item 122: The isolated host cell of item 120 or item 121, wherein the host cell is a mammalian cell or an insect cell. 
     Item 123: A vector system comprising one or more vectors encoding a first, second, third, and fourth polypeptide chain of a binding protein of any one of items 1-117. 
     Item 124: The vector system of item 123, wherein the vector system comprises a first vector encoding the first polypeptide chain of the binding protein, a second vector encoding the second polypeptide chain of the binding protein, a third vector encoding the third polypeptide chain of the binding protein, and a fourth vector encoding the fourth polypeptide chain of the binding protein. 
     Item 125: The vector system of item 123, wherein the vector system comprises a first vector encoding the first and second polypeptide chains of the binding protein, and a second vector encoding the third and fourth polypeptide chains of the binding protein. 
     Item 126: The vector system of any one of items 123-125, wherein the one or more vectors are expression vectors. 
     Item 127: An isolated host cell comprising the vector system of any one of items 123-126. 
     Item 128: The isolated host cell of item 127, wherein the host cell is a mammalian cell or an insect cell. 
     Item 129: A method of producing a binding protein, the method comprising: a) culturing a host cell of any one of items 120-122 and items 127-128 under conditions such that the host cell expresses the binding protein; and b) isolating the binding protein from the host cell. 
     Item 130: A method of preventing and/or treating HIV infection in a patient comprising administering to the patient a therapeutically effective amount of at least one binding protein of any one of items 1-117. 
     Item 131: The method of item 130, wherein the binding protein is co-administered with standard anti-retroviral therapy. 
     Item 132: The method of item 130 or item 131, wherein administration of the at least one binding protein results in the neutralization of one or more HIV virions. 
     Item 133: The method of any one of items 130-132, wherein administration of the at least one binding protein results in the elimination of one or more latently and/or chronically HIV-infected cells in the patient. 
     Item 134: The method of any one of items 130-133, wherein the patient is a human. 
     Item 135: The binding protein of any one of items 1-117 for the prevention or treatment of an HIV infection in a patient. 
     Item 136: The binding protein of item 135, wherein the binding protein is co-administered with standard anti-retroviral therapy. 
     Item 137: The binding protein of item 135 or item 136, wherein the binding protein causes the neutralization of one or more HIV virions in the patient. 
     Item 138: The binding protein of any one of items 135-137, wherein the binding protein causes the elimination of one or more latently and/or chronically HIV-infected cells in the patient. 
     Item 139: The binding protein of any one of items 135-138, wherein the patient is a human. 
     EXAMPLES 
     The Examples that follow are illustrative of specific embodiments of the disclosure, and various uses thereof. They are set forth for explanatory purposes only, and should not be construed as limiting the scope of the invention in any way. 
     Example 1: Production of Trispecific Binding Proteins Targeting the HIV-1 Env Glycoprotein 
     The HIV-1 envelope glycoprotein (Env/gp160) is located on the surface of the virus particle, and is composed of a homo-trimer comprising three non-covalently-linked transmembrane gp41 and gp120 complexes. Env enables viral entry into target cells by the binding of gp120 to HIV&#39;s main receptor (CD4) and co-receptor (CCR5 or CXCR4), followed by the induction of viral/cellular membrane fusion facilitated by conformational changes in gp41, resulting in entry of the viral capsid and delivery of the viral genome into the host cell. Additionally, Env is expressed on the surface of infected cells. 
     Env acts as the only target for neutralizing antibodies on the HIV-1 virion. Binding of neutralizing antibodies to viral Env inhibits viral attachment/entry. Moreover, binding of neutralizing antibodies to HIV-1 infected, Env expressing cells leads to their destruction by Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement Dependent Cytotoxicity (CDC), resulting in reduction of the latent viral reservoir. Thus, neutralizing antibodies targeting Env are an attractive area for anti-viral therapy development. However, because of the high sequence diversity and mutation rate of the HIV-1 virus, developing neutralizing antibodies targeting Env has proven challenging due to the high likelihood that a given HIV-1 strain either lacks the epitope of any given neutralizing antibody, or the strain has evolved a mutation to become resistant to the antibody. Strategies must be developed to mitigate the breakthrough of viral strains when developing novel neutralizing antibodies targeting HIV-1. The studies described herein explore the development of novel trispecific binding proteins comprising four polypeptides forming three antigen binding sites that specifically bind three different epitopes on the HIV Env glycoprotein, and use of these novel trispecific binding proteins in neutralizing HIV-1. 
     Methods 
     Binding Protein Production and Purification 
     The vectors expressing the trispecific binding proteins were constructed by inserting the designed heavy and light chain genes into a mammalian expression vector. Corresponding heavy and light chain pairing occurred spontaneously, and heterodimer formation was promoted by Knob-in-Hole mutations engineered in the Fc region. 
     Binding proteins were produced in Expi293 cells by cotransfection of four expression plasmids (Life Technologies, Expi293™ Expression System Kit, Cat. No. A14635). Binding proteins were purified using a two-step purification scheme. First, binding proteins were captured on protein A affinity chromatography resin, washed, and then eluted in glycine at pH 3.0. The eluted proteins were then dialyzed in PBS, concentrated, and filtered. The filtered antibodies were further purified using a Superdex 200 SEC column to obtain monomeric binding proteins. 
     Affinity Measurements of the Binding Proteins 
     Binding affinities of anti-HIV trispecific binding proteins were measured by surface plasmon resonance (SPR) using a Biacore3000 instrument (GE Healthcare). The assay buffer used was HBS-EP (GE Healthcare). 
     The affinity of the indicated proteins for the MPER binding site on the HIV-1 protein gp41 was measured by surface plasmon resonance (SPR) analysis using a Biacore Instrument as follows: binding proteins were first captured on a CM5 chip coupled with anti-human Fc antibody, followed by flow through of varying concentrations (100 nM-6.25 nM) of the MPER binding peptide (Acetyl-RRRNEQELLELDKWASLWNWFDITNWLWYIRRR-Ttds-Lys-(Biotin)-NH2) (SEQ ID NO: 284) at 30 μL per minute, and binding was detected by measurement of association for 240 seconds, and dissociation for 300 seconds on a Biacore 3000 at 25° C. HBS-EP buffer was used for sample dilution, as well as running buffer. Regeneration of the chip was done with 3 M MgCl2 at 30 μL per minute. For data analysis the BIAevaluation software v.4.1 (GE Healthcare) was used. Data were fit globally using a 1:1 Langmuir model with mass transfer. After software-based curve fitting, the ON and OFF rates at each concentration of MPER binding peptide was calculated and used to obtain a binding affinity for each binding protein. 
     The affinity of the indicated proteins for the CD4BS binding site on the HIV-1 protein gp120 was measured by SPR as follows: recombinant HIV-1 gp120 (Thr27-Arg498) protein (HIV-1/Clade B/C (CN54), ARCO Biosystems (Cat. #GP4-V15227)) was captured on a CM5 chip, followed by flow through of varying concentrations (100 nM-6.25 nM) of the binding proteins, and binding was detected by measurement of association for 240 seconds, and dissociation for 300 seconds on a Biacore 3000 at 25° C. HBS-EP buffer was used for sample dilution, as well as running buffer. Regeneration of the chip was done with 3 M MgCl 2  at 30 μL per minute. For data analysis the BIAevaluation software v.4.1 (GE Healthcare) was used. Data were fit globally using a 1:1 Langmuir model with mass transfer. After software-based curve fitting, the ON and OFF rates at each concentration of Binding Protein was calculated and used to obtain a binding affinity for each binding protein. 
     Conformational Stability and Aggregation Assays 
     Conformational stability of the trispecific binding proteins was assessed by determining the melting point T m  and aggregation onset temperature (T agg ). 
     Melting point T m  measurements were performed by differential scanning fluorimetry (DSF). Samples were diluted in D-PBS buffer (Invitrogen) to a final concentration of 0.2 μg/μL including a 4× concentration solution of SYPRO-Orange dye (Invitrogen, 5000× stock in DMSO) in D-PBS in white sem-skirt 96-well plates (BIORAD). All measurements were done in duplicate using a MyiQ2 real time PCR instrument (BIORAD). Negative first derivative curves (−d(RFU)/dT) of the melting curves were generated in the iQ5 software v2.1 (BIORAD). Data were then exported into Excel for T m  determination and graphical display. 
     Melting Point T m  and aggregation onset temperature (T agg ) were also measured by static light scattering (SLS) using a Unit instrument (Unchained Labs). 9 μL of each sample was loaded undiluted into a multicuvette array. The samples were then heated from 20° C. to 95° C. at a heating rate of 0.3° C./minute. The barycentric mean (BCM) of the tryptophan fluorescence spectra was used to measure the protein melting curve, and determine the T m  values. The 266 nm static light scattering (SLS) signal was used to measure the aggregation curve and determine the T agg . Data analysis was performed using the Unit analysis software v2.1. 
     Results 
     A novel strategy was developed for improving neutralizing antibody efficacy against HIV-1, while concomitantly limiting the likelihood of viral breakthrough due to high sequence diversity and/or viral mutation. This strategy involved the generation of trispecific binding proteins comprising four polypeptides that formed three antigen binding sites that specifically bind three different epitopes on the HIV Env glycoprotein ( FIG. 1 ). Each antigen binding site comprised the VH and VL domain from a different HIV-1 neutralizing antibody that targeted a distinct epitope on the Env glycoprotein. The trispecific binding proteins contained a first pair of polypeptides that possessed dual variable domains having a cross-over orientation forming two distinct antigen binding sites (called the CODV Ig format), and a second pair of polypeptides, each with a single variable domain that formed a third antigen binding site ( FIGS. 1A and 1B ). 
     The first pair of polypeptides (that possessed the dual variable domains) comprised a first polypeptide having the structure V L2 -Linker-V L1 -Linker-Immunoglobulin light chain constant domain, and a second polypeptide having the structure V H1 -Linker-V H2 -Linker-Immunoglobulin C H1 , hinge, C H2 , and C H3  heavy chain constant domains, resulting in a pair of polypeptides which had a cross over orientation that formed two distinct antigen binding sites: V H1 -V L1  and V H2 -V L2  ( FIGS. 1C and 1D , see light and heavy chains B). The second pair of polypeptides (that each possessed a single variable domain) comprised a first polypeptide having the structure V H3 -Immunoglobulin C H1 , hinge, C H2 , and C H3  heavy chain constant domains, and a second polypeptide having the structure V L3 -Immunoglobulin light chain constant domain, resulting in a pair of polypeptides that formed a third antigen binding site: V H3 -V L3  ( FIGS. 1C and 1D , see light and heavy chains A). In addition, the trispecific binding proteins were constructed to include an LS mutation. Furthermore, the trispecific binding proteins were constructed such that within one binding protein, one C H3  domain included a knob mutation and the other C H3  domain included a hole mutation to facilitate heterodimerization of the heavy chains ( FIG. 1 ). 
     Using the above described approach for trivalent binding protein design, three trispecific binding proteins (Binding Proteins 2, 3, and 24) were generated. These trispecific binding proteins were created by grafting onto a trispecific binding protein framework the VH and VL domains isolated from antibodies targeting three distinct epitopes on the HIV-1 Env glycoprotein: MPER Ab (targeting the MPER epitope on gp41), CD4BS Ab “b” (targeting the CD4 Binding Site on gp120), and V1/V2 directed Ab “a” (targeting the V1/V2 domain on gp120). Binding Protein 2 was constructed such that the first pair of polypeptides (which formed two antigen binding sites) targeted the HIV-1 Env glycoprotein epitopes MPER and V1/V2, and the second pair of polypeptides (which formed the single antigen binding site) targeted the HIV-1 Env glycoprotein epitope CD4BS (Binding Protein 2=MPER×V1/V2/CD4BS). Binding Protein 3 was constructed such that the first pair of polypeptides (which formed two antigen binding sites) targeted the HIV-1 Env glycoprotein epitopes V1/V2 and MPER, and the second pair of polypeptides (which formed the single antigen binding site) targeted the HIV-1 Env glycoprotein epitope CD4BS (Binding Protein 3=V1/V2×MPER/CD4BS). Binding Protein 24 was constructed such that the first pair of polypeptides (which formed two antigen binding sites) targeted the HIV-1 Env glycoprotein epitopes V1/V2 and CD4BS, and the second pair of polypeptides (which formed the single antigen binding site) targeted the HIV-1 Env glycoprotein epitope MPER (Binding Protein 24=V1/V2×CD4BS/MPER). The three trispecific binding proteins, as well as their parental antibodies, were purified over protein A affinity resin ( FIGS. 2A and 3A ) followed by size exclusion chromatography ( FIGS. 2B and 3B ) to obtain monomeric proteins suitable for further characterization. All three trispecific binding proteins were stable and formed monomers at high frequency. 
     To test the potential for developing binding proteins targeting two different HIV-1 Env protein epitopes (instead of three), bispecific binding proteins were designed based upon the above described CODV Ig format (See WO 2012/135345), using two different VH and VL domains from the same parental antibodies used to create the trispecific binding proteins. However, the bispecific binding proteins with these specific variable domains did not purify well as monomers, showing significantly increased aggregate formation when compared to the corresponding trispecific binding proteins ( FIGS. 4A and 4B ). 
     Next, the binding affinity of the purified trispecific binding proteins (and their parental antibodies) was measured for the HIV-1 Env glycoprotein epitopes on gp41 and gp120. First, the binding affinity for gp41 was measured for the three trispecific binding proteins, as well as the parental MPER antibody, by Biacore assay using the MPER binding peptide ( FIG. 5 ). The binding affinity for the MPER antibody was calculated to be 18.7 nM. Surprisingly, the three trispecific binding proteins all had a higher affinity for the MPER binding peptide than did the parental antibody (Table 3), with Binding Protein 2 having an approximately 3.1 fold higher affinity than the MPER antibody (6.05 nM vs. 18.7 nM, respectively). 
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Affinity measurements for the MPER binding peptide 
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                   
                   
                   
                 MW 
               
               
                   
                   
                 ka  
                 kd 
                 Rmax 
                 KA  
                 KD 
                   
                 MPER 
               
               
                 Antibody 
                 Analyte 
                 (1/Ms) 
                 (1/s) 
                 (RU) 
                 (1/M) 
                 (M) 
                 Chi2 
                 (kDa) 
               
               
                   
               
               
                 MPER Ab 
                 Gp41- 
                 5.85E+04 
                 1.09E−03 
                 47.5 
                 5.35E+07 
                 1.87E−08 
                 0.55 
                 5.25 
               
               
                   
                 MPER JPT 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Binding 
                 Gp41- 
                 1.15E+05 
                 6.97E−04 
                 29.0 
                 1.65E+08 
                 6.05E−09 
                 0.27 
                 2.29 
               
               
                 Protein 2 
                 MPER JPT 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Binding 
                 Gp41- 
                 4.67E+04 
                 7.79E−04 
                 38.5 
                 6.00E+07 
                 1.67E−08 
                 0.41 
                 5.14 
               
               
                 Protein 3 
                 MPER JPT 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Binding 
                 Gp41- 
                 6.28E+04 
                 8.06E−04 
                 35.5 
                 7.80E+07 
                 1.28E−08 
                 0.48 
                 5.24 
               
               
                 Protein 24 
                 MPER JPT 
               
               
                   
               
            
           
         
       
     
     Similarly, the binding affinity for the CD4 Binding Site on gp120 was measured for the three trispecific binding proteins, as well as the parental CD4BS antibody, by Biacore assay ( FIG. 6 ). The three trispecific binding proteins all had a similar affinity for the CD4 Binding Site when compared to the parental antibody (Table 4). 
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 Affinity measurements for the CD4BS binding site 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 ka  
                 kd  
                 Rmax 
                 KD 
                   
               
               
                 Antibody 
                 (1/Ms) 
                 (1/s) 
                 (RU) 
                 (M) 
                 Chi2 
               
               
                   
               
               
                 CD4BS 
                 2.79E+05 
                 2.32E−04 
                 31.4 
                 8.30E−10 
                 1.17 
               
               
                 Ab “b” 
                   
                   
                   
                   
                   
               
               
                 Binding 
                 2.31E+05 
                 2.41E−04 
                 34.0 
                 1.04E−09 
                 0.74 
               
               
                 Protein 2 
                   
                   
                   
                   
                   
               
               
                 Binding 
                 7.58E+04 
                 2.75E−04 
                 38.2 
                 3.63E−09 
                 0.19 
               
               
                 Protein 3 
                   
                   
                   
                   
                   
               
               
                 Binding 
                 1.46E+05 
                 2.52E−04 
                 41.6 
                 1.73E−09 
                 0.38 
               
               
                 Protein 24 
                   
                   
                   
                   
                   
               
               
                   
               
            
           
         
       
     
     Thus, the trispecific binding proteins were able to bind both of the tested target epitopes on the HIV-1 Env glycoprotein (Table 5). Moreover, all three trispecific binding proteins bound the target epitopes with affinities approximately equal to or exceeding those of their parental antibodies. Binding affinity of the VT/V2 directed Ab “a”, as well as of the VT/V2 directed Ab “a” binding sites within the three trispecific binding proteins 2, 3, and 24 could not be determined by Biacore analysis because this required a specific gp120 protein antigen which was unavailable. 
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Summary of binding capabilities of  
               
               
                 tested binding proteins 
               
            
           
           
               
               
               
               
            
               
                   
                   
                 Binding  
                 Binding  
               
               
                   
                 Sample 
                 on gp120? 
                 on gp41? 
               
               
                   
                   
               
               
                   
                 MPER Ab 
                 No 
                 Yes 
               
               
                   
                 CD4BS Ab 
                 Yes 
                 No 
               
               
                   
                 “b” 
                   
                   
               
               
                   
                 V1/V2 directed 
                 No 
                 No 
               
               
                   
                 Ab “a” 
                   
                   
               
               
                   
                 Binding 
                 Yes 
                 Yes 
               
               
                   
                 Protein 2 
                   
                   
               
               
                   
                 Binding 
                 Yes 
                 Yes 
               
               
                   
                 Protein 3 
                   
                   
               
               
                   
                 Binding 
                 Yes 
                 Yes 
               
               
                   
                 Protein 24 
                   
                   
               
               
                   
                   
               
            
           
         
       
     
     The biophysical properties were tested for the trispecific binding proteins and parental antibodies (Table 6). All of the tested proteins had similar stabilities and limited propensities to form aggregates. 
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 Conformational stability/aggregation of the binding proteins 
               
            
           
           
               
               
               
               
            
               
                   
                   
                 Intrinsic AA 
                 SLS at 
               
               
                   
                 DSF T m   
                 Fluo T m   
                 266 nm T agg    
               
               
                 Sample 
                 (° C.) 
                 (° C.) 
                 (° C.) 
               
               
                   
               
               
                 MPER Ab 
                 69/75 
                 68 
                 71 
               
               
                 CD4BS Ab 
                 69 
                 66 
                 68 
               
               
                 “b” 
                   
                   
                   
               
               
                 V1/V2 directed 
                 69 
                 64 
                 67 
               
               
                 Ab “a” 
                   
                   
                   
               
               
                 Binding 
                 60/70 
                 54 
                 58 
               
               
                 Protein 2 
                   
                   
                   
               
               
                 Binding 
                 57/70 
                 55 
                 56 
               
               
                 Protein 3 
                   
                   
                   
               
               
                 Binding 
                 56/71 
                 53 
                 54 
               
               
                 Protein 24 
                   
                   
                   
               
               
                   
               
            
           
         
       
     
     These experiments indicated that stable, monomeric, trispecific binding proteins targeting three distinct epitopes on the HIV-1 Env glycoprotein could be constructed and efficiently purified. Furthermore, the trispecific binding proteins retained their ability to bind their target epitopes, having similar or improved affinity relative to their parental antibodies. Finally, the trispecific binding proteins had suitable biophysical properties, and showed significantly less aggregation than the corresponding bispecific binding proteins. 
     Example 2: Characterization of the Binding Proteins 
     Due to the success of developing three trispecific binding proteins with appropriate biophysical properties and binding abilities (as described in Example 1), 21 additional trispecific binding proteins were developed and tested. The experiments described herein explored the ability of the 24 trispecific binding proteins to neutralize HIV-1 in vitro, and the pharmacokinetic properties of a number of these trispecific binding proteins in vivo. 
     Neutralization assays were performed using the TZM-bl assay which measures neutralization as a function of reductions in HIV-1 Tat-regulated firefly luciferase (Luc) reporter gene expression after a single round of infection with Env-pseudotyped viruses. The assays were performed as described in Marcella Sarzotti-Kelsoe et al., J. Immunological Methods, 409:131-146 (2014). The neutralization results of various antibodies are shown in Tables 8-10. 
     Methods 
     Production of Env-Pseudotyped Viruses 
     Assay stocks of Env-pseudotyped viruses were produced in 293T/17 cells by co-transfection with two plasmids: an Env expression plasmid and a plasmid expressing the entire HIV-1 genome except for Env. Co-transfection of these plasmids produced infectious pseudovirus particles which were capable of delivering the Tat gene into target cells, but infections with these pseudovirions could not themselves produce infectious viral progeny. 
     Viral Neutralization Assay 
     Neutralization of HIV infection using TZM-bl cells (also known as JC53BL-13 cells) was performed as described previously (Marcella Sarzotti-Kelsoe et al., J. Immunological Methods, 409:131-146 (2014)). Briefly, a single round of infection using the Env-pseudotyped HIV-1 virions was carried out in TZM-bl cells (a CXCR-4-positive HeLa cell clone). TZM-bl cells were engineered to express CD4 and CCR5, and to contain integrated reporter genes for firefly luciferase and  E. coli  β-galactosidase under the control of an HIV long-terminal repeat. Reporter gene expression was induced in trans by viral Tat protein (delivered by the pseudotyped viruses) soon after single cycle infection. Luciferase activity was quantified as relative luminescence units (RLU), and was directly proportional to the number of infectious virus particles present in the initial inoculum over a wide range of values. Neutralization was measured as a function of decreased Tat-regulated Firefly luciferase (Luc) reporter gene expression after administration of varying concentrations of the indicated binding proteins. Neutralization titers were identified as the protein dilution at which RLUs were reduced by 80% compared to virus control wells after subtraction of background RLUs. The assay was performed in 96-well plates for high throughput capacity, and well-characterized reference strains were utilized for uniformity across studies. 
     Pharmacokinetic (PK) Measurements 
     Female Indian rhesus macaques weighing between 3 and 6 kg were randomly assigned to groups according to body weight (two macaques per group) and were intravenously injected with the indicated concentration of binding proteins. Blood was collected from the animals before the injection on day 0, and 30 minutes, 6 hours, 1 day, 2 days, 4 days, 7 days, 14 days, 21 days and 28 days after injection. The serum concentration of each binding protein was quantified in the plasma from the collected blood using an RSC3-based ELISA assay. 
     Results 
     21 additional trispecific binding proteins targeting three distinct HIV-1 Env glycoprotein epitopes were generated and purified as described in Example 1. These 21 additional trispecific binding proteins (Binding Proteins 1 and 4-23) were created by grafting onto a trispecific binding protein framework the V H  and V L  domains isolated from antibodies targeting distinct HIV-1 epitopes on the HIV-1 Env glycoprotein: the anti-MPER antibodies MPER Ab “a” and MPER Ab “b” (targeting the MPER epitope on gp41), the anti-CD4BS antibodies CD4BS Ab “a” and CD4BS Ab “b” (targeting the CD4 Binding Site on gp120), the anti-V1/V2 antibodies V1/V2 directed Ab “a” and V1/V2 directed Ab “b” (targeting the V1/V2 domain on gp120), and the anti-V3 antibody V3 directed Ab (targeting the V3 loop on gp120) (Table 7). 
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 Epitope binding site composition of the trispecific binding proteins 
               
            
           
           
               
               
            
               
                 Binding Protein: 
                 Epitope Binding Site: 
               
               
                   
               
               
                  1 
                 MPER × V1/V2 directed/CD4BS 
               
               
                  2 
                 MPER × V1/V2 directed/CD4BS 
               
               
                  3 
                 V1/V2 directed × MPER/CD4BS 
               
               
                  4 
                 MPER × V1/V2 directed/CD4BS 
               
               
                  5 
                 MPER × V3 directed/CD4BS 
               
               
                  6 
                 V1/V2 directed × MPER/CD4BS 
               
               
                  7 
                 V3 directed × V1/V2 directed/CD4BS 
               
               
                  8 
                 MPER × V1/V2 directed/CD4BS 
               
               
                  9 
                 MPER × V1/V2 directed/CD4BS 
               
               
                 10 
                 V1/V2 directed × MPER/CD4BS 
               
               
                 11 
                 MPER × V1/V2 directed/CD4BS 
               
               
                 12 
                 MPER × V3 directed/CD4BS 
               
               
                 13 
                 MPER × V3 directed/V1/V2 directed 
               
               
                 14 
                 V1/V2 directed × MPER/CD4BS 
               
               
                 15 
                 MPER × V3 directed/V1/V2 directed 
               
               
                 16 
                 MPER × V3 directed/CD4BS 
               
               
                 17 
                 V1/V2 directed × V3 directed/CD4BS 
               
               
                 18 
                 V3 directed × MPER/CD4BS 
               
               
                 19 
                 V3 directed × V1/V2 directed/MPER 
               
               
                 20 
                 V3 directed × V1/V2 directed/CD4BS 
               
               
                 21 
                 MPER × CD4BS/V1/V2 directed 
               
               
                 22 
                 CD4BS × MPER/V1/V2 directed 
               
               
                 23 
                 CD4BS × V1/V2 directed/MPER 
               
               
                 24 
                 V1/V2 directed × CD4BS/MPER 
               
               
                   
               
            
           
         
       
     
     The viral neutralization capabilities of five of the trispecific binding proteins (and their parental antibodies) at varying concentrations were tested against a panel of 208 different HIV-1 Env-pseudotyped viruses (Table 8). Binding protein-mediated neutralization of the pseudotyped HIV-1 isolates was measured using the TZM-bl luciferase reporter gene assay. The inhibitory dose for each binding protein was calculated for each pseudotyped virus as the dilution that caused an 80% reduction in luminescence (IC 80 ) after infection. Surprisingly, the IC 80  geometric means calculated for each of the tested trispecific binding proteins was lower than the parental antibodies, suggesting that these trispecific binding proteins were more potent at neutralizing pseudotyped HIV-1 than their parental neutralizing antibodies. 
     
       
         
           
               
             
               
                 TABLE 8 
               
             
            
               
                   
               
               
                 IC 80  measurements from viral neutralization assay 
               
            
           
           
               
               
               
            
               
                   
                   
                 Parental Antibody: 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                 V1/V2 
                   
                   
                   
               
               
                   
                   
                   
                 directed  
                 V3 
                 CD4BS 
                 CD4BS 
               
               
                   
                 Binding protein: 
                 MPER 
                 Ab 
                 directed 
                 Ab  
                 Ab  
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 15 
                 1 
                 2 
                 19 
                 20 
                 3 
                 Ab 
                 “a” 
                 Ab 
                 “b” 
                 “a” 
               
               
                 #Viruses 
                 208 
                 208 
                 208 
                 208 
                 208 
                 208 
                 208 
                 208 
                 208 
                 208 
                 208 
               
               
                   
               
               
                 Total VS 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Neutralized: 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 IC 80  &lt;50 μg/mL 
                 190 
                 202 
                 206 
                 198 
                 206 
                 206 
                 203 
                 151 
                 113 
                 202 
                 183 
               
               
                 IC 80  &lt;10 μg/mL 
                 180 
                 199 
                 206 
                 180 
                 206 
                 206 
                 193 
                 149 
                 109 
                 200 
                 175 
               
               
                 IC 80  &lt;1.0 μg/mL 
                 166 
                 169 
                 191 
                 145 
                 188 
                 186 
                 61 
                 133 
                 98 
                 184 
                 108 
               
               
                 IC 80  &lt;0.1 μg/mL 
                 122 
                 109 
                 136 
                 80 
                 144 
                 123 
                 10 
                 99 
                 72 
                 79 
                 10 
               
               
                 IC 80  &lt;0.01 μg/mL 
                 74 
                 7 
                 70 
                 22 
                 54 
                 47 
                 5 
                 24 
                 26 
                 6 
                 0 
               
               
                 % VS 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Neutralized: 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 IC 80  &lt;50 μg/mL 
                 91 
                 97 
                 99 
                 95 
                 99 
                 99 
                 98 
                 73 
                 54 
                 97 
                 88 
               
               
                 IC 80  &lt;10 μg/mL 
                 87 
                 96 
                 99 
                 87 
                 99 
                 99 
                 93 
                 72 
                 52 
                 96 
                 84 
               
               
                 IC 80  &lt;1.0 μg/mL 
                 80 
                 81 
                 92 
                 70 
                 90 
                 89 
                 29 
                 64 
                 47 
                 88 
                 52 
               
               
                 IC 80  &lt;0.1 μg/mL 
                 59 
                 52 
                 65 
                 38 
                 69 
                 59 
                 5 
                 48 
                 35 
                 38 
                 5 
               
               
                 IC 80  &lt;0.01 μg/mL 
                 36 
                 3 
                 34 
                 11 
                 26 
                 23 
                 2 
                 12 
                 13 
                 3 
                 0 
               
               
                 Median IC 80   
                 0.033 
                 0.088  
                 0.026 
                 0.164  
                 0.029 
                 0.045 
                 1.69 
                 0.037 
                 0.054 
                 0.149 
                 0.780 
               
               
                 Geometric Mean 
                 0.033 
                 0.135  
                 0.028 
                 0.199  
                 0.034 
                 0.051 
                 1.34 
                 0.063 
                 0.057 
                 0.144 
                 0.814 
               
               
                   
               
            
           
         
       
     
     Next, the viral neutralization capabilities of a larger panel of trispecific binding proteins (and their parental antibodies) at varying concentrations were tested against 20 pseudotyped viruses representing 10 different HIV-1 clades (Table 9). The trispecific binding proteins provided robust protection against infection with these 20 viruses (Table 10). 
     
       
         
           
               
             
               
                 TABLE 9 
               
             
            
               
                   
               
               
                 20 representative viruses used for viral  
               
               
                 neutralization assay 
               
            
           
           
               
               
               
            
               
                   
                 Virus 
                 Clade 
               
               
                   
                   
               
               
                   
                 KER2008.12.SG3 
                 A 
               
               
                   
                 620345.c1.SG3 
                 AE 
               
               
                   
                 DJ263.8.SG3 
                 AG 
               
               
                   
                 T266-60.SG3 
                 AG 
               
               
                   
                 T278-50.SG3 
                 AG 
               
               
                   
                 BL01.DG.SG3 
                 B 
               
               
                   
                 BR07.DG.SG3 
                 B 
               
               
                   
                 CNE57.SG3 
                 B 
               
               
                   
                 H086.8.SG3 
                 B 
               
               
                   
                 QH0692.42.SG3 
                 B 
               
               
                   
                 SS1196.01.SG3 
                 B 
               
               
                   
                 CNE21.SG3 
                 BC 
               
               
                   
                 6471.V1.C16.SG3 
                 C 
               
               
                   
                 CAP210.E8.SG3 
                 C 
               
               
                   
                 DU156.12.SG3 
                 C 
               
               
                   
                 DU422.01.SG3 
                 C 
               
               
                   
                 TV1.29.SG3 
                 C 
               
               
                   
                 ZM106.9.SG3 
                 C 
               
               
                   
                 3817.v2.c59.SG3 
                 CD 
               
               
                   
                 X2088.c9.SG3 
                 G 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 10 
               
             
            
               
                   
               
               
                 IC 80   measurements from viral neutralization assay of 20 representative viruses 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                 Total VS  
                 % VS  
                   
                   
               
               
                   
                   
                 Neutralized 
                 Neutralized 
                   
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                   
                 # 
                 IC 80   
                 IC 80   
                 IC 80   
                 IC 80   
                 Median 
                 Geometric 
               
               
                   
                 Viruses 
                 &lt;50 μg/mL 
                 &lt;1 μg/mL 
                 &lt;50 μg/mL 
                 &lt;1 μg/mL 
                 IC 80   
                 Mean 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Binding Protein 4 
                 20 
                 17 
                 11 
                 85 
                 55 
                 0.474 
                 0.398 
               
               
                 Binding Protein 5 
                 20 
                 14 
                 11 
                 70 
                 55 
                 0.199 
                 0.324 
               
               
                 Binding Protein 6 
                 20 
                 16 
                 9 
                 80 
                 45 
                 0.453 
                 0.449 
               
               
                 Binding Protein 7 
                 20 
                 16 
                 9 
                 80 
                 45 
                 0.523 
                 0.312 
               
               
                 Binding Protein 8 
                 20 
                 17 
                 12 
                 85 
                 60 
                 0.578 
                 0.488 
               
               
                 Binding Protein 9 
                 20 
                 14 
                 9 
                 70 
                 45 
                 0.836 
                 0.531 
               
               
                 Binding Protein 10 
                 20 
                 16 
                 12 
                 80 
                 60 
                 0.222 
                 0.173 
               
               
                 Binding Protein 11 
                 20 
                 18 
                 15 
                 90 
                 75 
                 0.310 
                 0.181 
               
               
                 Binding Protein 12 
                 20 
                 17 
                 12 
                 85 
                 60 
                 0.526 
                 0.566 
               
               
                 Binding Protein 13 
                 20 
                 19 
                 12 
                 95 
                 60 
                 0.202 
                 0.189 
               
               
                 Binding Protein 14 
                 20 
                 17 
                 15 
                 85 
                 75 
                 0.208 
                 0.088 
               
               
                 Binding Protein 15 
                 20 
                 17 
                 10 
                 85 
                 50 
                 0.345 
                 0.378 
               
               
                 Binding Protein 16 
                 20 
                 18 
                 11 
                 90 
                 55 
                 0.228 
                 0.314 
               
               
                 Binding Protein 17 
                 20 
                 17 
                 12 
                 85 
                 60 
                 0.086 
                 0.180 
               
               
                 Binding Protein 18 
                 20 
                 15 
                 10 
                 75 
                 50 
                 0.536 
                 0.501 
               
               
                 Binding Protein 19 
                 20 
                 18 
                 11 
                 90 
                 55 
                 0.563 
                 0.538 
               
               
                 Binding Protein 20 
                 20 
                 18 
                 14 
                 90 
                 70 
                 0.224 
                 0.229 
               
               
                 Binding Protein 21 
                 20 
                 15 
                 9 
                 75 
                 45 
                 0.627 
                 0.501 
               
               
                 Binding Protein 2 
                 20 
                 18 
                 13 
                 90 
                 65 
                 0.375 
                 0.222 
               
               
                 Binding Protein 22 
                 20 
                 13 
                 8 
                 65 
                 40 
                 0.856 
                 0.634 
               
               
                 Binding Protein 23 
                 20 
                 17 
                 6 
                 85 
                 30 
                 1.930 
                 1.129 
               
               
                 Binding Protein 3 
                 20 
                 18 
                 12 
                 90 
                 60 
                 0.469 
                 0.287 
               
               
                 Binding Protein 24 
                 20 
                 16 
                 7 
                 80 
                 35 
                 2.130 
                 1.054 
               
               
                 MPER Ab “a” 
                 20 
                 16 
                 8 
                 80 
                 40 
                 1.007 
                 0.981 
               
               
                 MPER Ab “b” 
                 20 
                 16 
                 16 
                 80 
                 80 
                 0.071 
                 0.024 
               
               
                 CD4BS Ab “b” 
                 20 
                 15 
                 9 
                 75 
                 45 
                 0.181 
                 0.399 
               
               
                 V1/V2 directed Ab “a” 
                 20 
                 11 
                 9 
                 55 
                 45 
                 0.060 
                 0.094 
               
               
                 V3 directed Ab 
                 20 
                 12 
                 10 
                 60 
                 50 
                 0.183 
                 0.136 
               
               
                 CD4BS Ab “a” 
                 20 
                 10 
                 1 
                 50 
                 5 
                 1.530 
                 1.811 
               
               
                 V1/V2 directed Ab “b” 
                 20 
                 9 
                 9 
                 45 
                 45 
                 0.051 
                 0.039 
               
               
                   
               
            
           
         
       
     
     Finally, the pharmacokinetics (PR) of a subset of the trispecific binding proteins and parental antibodies were tested in rhesus macaques. Briefly, 10 or 20 mg/kg of the proteins were intravenously injected into female rhesus macaques, and ELISA assays were performed on the plasma from blood samples taken prior to injection, and on the plasma from blood samples taken at many time points after the injection (up to 42 days) ( FIG. 7 ). All of the trispecific binding proteins could be detected at least 14 days after IV administration, with Binding Protein 1 remaining detectable at least 35 days after injection, showing that the binding proteins were stable in vivo. 
     Taken together, this data suggested that broadly neutralizing trispecific binding proteins could be constructed which targeted three distinct epitopes on the HIV-1 Env glycoprotein. These binding proteins showed similar or increased potency/much improved neutralizing capabilities (breadth) relative to the parental neutralizing antibodies. Furthermore, these trispecific binding proteins appeared to be well tolerated in vivo. Without wishing to be bound by theory, the development of broadly neutralizing trispecific binding proteins targeting multiple epitopes on HIV may allow for improved anti-viral therapy relative to monospecific or bispecific antibodies, as HIV viral particles are less likely to be resistant to all three antigen binding sites on the neutralizing trispecific binding proteins than the single or dual antigen binding sites on monospecific or bispecific neutralizing antibodies, respectively. 
     Example 3: Characterization of T-Cell Engagers 
     As noted above, Env is expressed on the surface of HIV-infected cells. Because of this, Env can act as an antibody target to identify infected cells, and induce Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement Dependent Cytotoxicity (CDC), resulting in reduction of the latent viral reservoir. The studies described herein explore the development of novel trispecific binding proteins (termed “T cell engagers”) that contain three antigen binding sites targeting three different antigens (HIV-1 Env glycoprotein, CD3, and CD28). These novel proteins not only include antigen binding sites from neutralizing antibodies, but also the ability to bind effector T cells, bringing them into close proximity to infected target cells, thus inducing HIV-infected cell lysis. 
     Methods 
     Binding Properties of T-Cell Engagers 
     The binding properties of the T-cell engagers was measured by ELISA assay using a horse radish peroxidase-conjugated anti-Fab probe to detect T-cell engager binding to the surface of ELISA plates coated with CD3, CD28, or Resurfaced Stabilized Core 3 (RSC3) protein of gp120. Human CD3ge-hIgG4 (KIH) (Cat. No: 03-01-0051) from Cambridge Biologics, MA, USA; Human CD28-hIgG4 (Cat. No: 03-01-0303) from Cambridge Biologics, MA, USA. 
     T-Cell Activation Assay 
     CD4 and CD8 T cell activation were measured as follows: peripheral blood mononuclear cells (PBMCs) were enriched from buffy coats obtained from naïve donors (NIH blood bank) using magnetic beads (Miltenyi Biotec). These cells were co-cultured for 14-16 hours with either uninfected or HIV-1 infected CEM cells in the presence of increasing concentrations of the binding proteins (0.01-1.0 μg/mL) with brefeldin A. The cells were then stained for surface expression of T-cell markers (CD3, CD4, and CD8) and activation markers (CD25 and CD69), followed by intracellular staining for cytokines (IFN-γ, TNF-α, and IL-2) using fluorescently conjugated antibodies (BD Biosciences, eBiosciences, Biolegend). The number of CD4 and CD8 T cells expressing each cytokine or activation marker was determined by running the samples on an LSRII flow cytometer and analyzing the data with Flowjo software (Treeestar). 
     CD3 Downregulation 
     CD3 downregulation after T cell activation by the T-cell engagers was measured by staining activated PBMCs with non-competing mouse anti-human CD3 antibody and quantitated using flow cytometry. 
     Cytotoxicity Assay 
     Cytotoxicity of the T-cell engagers to CEM-BaL, ACH2, and J1.1 cells was monitored by flow cytometry as follows: latent cell lines (ACH2, J1.1, OM10) were obtained from the NIH AIDS Reagent Program. The activation of these cells was performed by culturing the cells in the presence or absence of TNF-α (10 ng/mL) for 14-16 hours. Activation was measured by determining the expression of cell surface HIV envelope glycoprotein by flow cytometry using an allophycocyanin-conjugated anti-HIV Env antibody (2G12). The CEM-IIIb, ACH2, J1.1 and OM10 cells were labeled with the membrane dye PKH-26 (Sigma) and used as target cells in a cytotoxicity assay. These labeled target cells were co-cultured for 14-16 hours at an E:T ratio of 10:1 with enriched human T cells as effector cells in the presence of increasing amounts of the binding proteins. The extent of cell lysis in the target cells was determined by staining with a live/dead cell marker (Life technologies) and measuring the number of dead cells in the labeled target cell population by running the samples on an LSRII flow cytometer followed by analysis using Flowjo software (Treestar). 
     Results 
     The capacity to develop T cell engagers with antigen binding sites targeting both T cell surface proteins and neutralizing epitopes on HIV-1 was explored. T cell engagers were constructed which contained two antigen binding sites targeting two different T cell surface receptors (CD3 and CD28), and a third antigen binding site targeting the HIV-1 Env glycoprotein ( FIGS. 8A and 8B ). In addition, the T cell engagers were constructed to include an LS mutation. Furthermore, the T cell engagers were constructed such that within one binding protein, one C H3  domain included a knob mutation and the other C H3  domain included a hole mutation to facilitate heterodimerization of the heavy chains ( FIGS. 8A and 8B ). 
     Using this approach, two T cell engagers were constructed which targeted both T cell surface proteins and the HIV-1 Env glycoprotein (Binding Protein 32 and CD3×CD28/CD4BS “b” Ab). These two T cell engagers were created by grafting onto a trispecific binding protein framework the V H  and V L  domains isolated from parental antibodies targeting the T cell surface proteins CD3 and CD28, and the anti-HIV-1 antibody CD4BS Ab “b” (targeting the CD4 Binding Site on gp120). Binding Protein 32 was constructed such that the first pair of polypeptides (which formed two antigen binding sites) targeted the T cell surface receptors CD28 and CD3, and the second pair of polypeptides (which formed the single antigen binding site) targeted the HIV-1 antigen CD4BS (Binding Protein 32=CD28×CD3/CD4BS). The CD3×CD28/CD4BS “b” Ab trispecific binding protein was constructed such that the first pair of polypeptides (which formed two antigen binding sites) targeted the T cell surface receptors CD3 and CD28, and the second pair of polypeptides (which formed the single antigen binding site) targeted the HIV-1 antigen CD4BS (Table 11). 
     
       
         
           
               
             
               
                 TABLE 11 
               
             
            
               
                   
               
               
                 Format of T-cell engagers 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 Arm 1 
                 Arm 2 
                 Arm 3 
               
               
                 Format 
                 Name of Construct 
                 Antigen 
                 Antigen 
                 Antigen 
               
               
                   
               
               
                 T cell engagers,  
                 CD3 × CD28/CD4BS  
                 CD4BS 
                 CD3 
                 CD28 
               
               
                 trispecific 
                 Ab “b” 
                   
                   
                   
               
               
                 T cell engagers,  
                 Binding Protein 32 
                 CD4BS 
                 CD28 
                 CD3 
               
               
                 trispecific 
                   
                   
                   
                   
               
               
                 Monospecific 
                 CD4BS IgG4 
                 CD4BS 
                 CD4BS 
                 — 
               
               
                   
               
            
           
         
       
     
     The ability of the two T cell engagers to bind to each of their three target antigens was tested by ELISA assay. The T cell engagers were capable of binding both the CD3 and CD28 T cell surface proteins with the CD3 and CD28 antigen binding sites in either orientation in the bispecific arms of the T cell engagers (i.e., CD3×CD28 for CD3×CD28/CD4BS Ab “b” or CD28×CD3 for Binding Protein 32). Both T cell engagers were also capable of binding to gp120 (as measured using the HIV-1 RSC3 protein, a gp120 variant lacking the V1, V2, and V3 variable regions) ( FIG. 9 ). 
     The effect on T cell activity was next tested for both of the T cell engagers. Incubation of the T cell engagers with monocytes revealed that the T cell engagers induced robust CD8 +  T cell activation ( FIG. 10 ). Similarly, the T cell engagers were capable of inducing significant CD4 +  T cell activation on PBMCs alone, or PBMCs incubated with either of the HIV-1 infected T cell lines CEM-NKr cells or CEM-BaL cells ( FIG. 11 ). Additionally, both of the T cell engagers reduced cell surface expression of CD3 on activated T cells ( FIG. 12 ). 
     Finally, the ability of the T cell engagers to induce lysis of HIV-infected cells was tested. The T cell engagers (and positive and negative control bispecific binding proteins targeting CD3 and an HIV antigen) were incubated with the HIV-1 infected T cell line CEM-BaL cells. Incubation of the T cell engagers with the infected cells induced robust cell lysis over a wide range of concentrations ( FIG. 13A ). Likewise, incubation of these T cell engagers induced lysis of the latently infected T cell line ACH2 cells ( FIG. 13B ), as well as J1.1 cells ( FIG. 13C ). Surprisingly, the T cell engagers showed comparable or better cytotoxic activity against chronic and latent HIV-infected cell lines when compared to the bispecific binding proteins. 
     Taken together, the novel T cell engagers described herein retained the ability from their parental antibodies to bind their target antigens on the HIV-1 Env glycoprotein gp120 on HIV-infected cells, as well as the cell-surface exposed T cell proteins CD3 and CD28. The T cell engagers induced robust CD4 +  and CD8 +  T cell activation, and diminished CD3 surface expression. Finally, these T cell engagers induced significant lysis of HIV-1 infected T cells. Without wishing to be bound by theory, these T cell engagers may provide a novel strategy for anti-viral therapeutics by reducing/eliminating the latent viral reservoir through T cell engagement in HIV/AIDS patients. 
     While the present disclosure includes various embodiments, it is understood that variations and modifications will occur to those skilled in the art. Therefore, it is intended that the appended claims cover all such equivalent variations that come within the scope of the disclosure. In addition, the section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described. 
     Each embodiment herein described may be combined with any other embodiment or embodiments unless clearly indicated to the contrary. In particular, any feature or embodiment indicated as being preferred or advantageous may be combined with any other feature or features or embodiment or embodiments indicated as being preferred or advantageous, unless clearly indicated to the contrary. 
     All references cited in this application are expressly incorporated by reference herein. 
     Sequences 
       
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Heavy and light chain SEQ ID NOs for binding proteins 1-53 and the target 
               
               
                 antigens to which the binding proteins are directed. 
               
            
           
           
               
               
               
            
               
                 Binding Protein 
                 SEQ ID NOs 
                 Target 
               
               
                   
               
               
                  1 
                 4, 3, 1, 2 
                 MPER × V1/V2 directed/CD4BS 
               
               
                  2 
                 12, 11, 9, 10 
                 MPER × V1/V2 directed/CD4BS 
               
               
                  3 
                 20, 19, 17, 18 
                 V1/V2 directed × MPER/CD4BS 
               
               
                  4 
                 28, 27, 25, 26 
                 MPER × V1/V2 directed/CD4BS 
               
               
                  5 
                 36, 35, 33, 34 
                 MPER × V3 directed/CD4BS 
               
               
                  6 
                 44, 43, 41, 42 
                 V1/V2 directed × MPER/CD4BS 
               
               
                  7 
                 52, 51, 49, 50 
                 V3 directed × V1/V2 directed/CD4BS 
               
               
                  8 
                 60, 59, 57, 58 
                 MPER × V1/V2 directed/CD4BS 
               
               
                  9 
                 68, 67, 65, 66 
                 MPER × V1/V2 directed/CD4BS 
               
               
                 10 
                 76, 75, 73, 74 
                 V1/V2 directed × MPER/CD4BS 
               
               
                 11 
                 84, 83, 81, 82 
                 MPER × V1/V2 directed/CD4BS 
               
               
                 12 
                 92, 91, 89, 90 
                 MPER × V3 directed/CD4BS 
               
               
                 13 
                 100, 99, 97, 98 
                 MPER × V3 directed/V1/V2 directed 
               
               
                 14 
                 108, 107, 105, 106 
                 V1/V2 directed × MPER/CD4BS 
               
               
                 15 
                 116, 115, 113, 114 
                 MPER × V3 directed/V1/V2 directed 
               
               
                 16 
                 124, 123, 121, 122 
                 MPER × V3 directed/CD4BS 
               
               
                 17 
                 132, 131, 129, 130 
                 V1/V2 directed × V3 directed/CD4BS 
               
               
                 18 
                 140, 139, 137, 138 
                 V3 directed × MPER/CD4BS 
               
               
                 19 
                 148, 147, 145, 146 
                 V3 directed × V1/V2 directed/MPER 
               
               
                 20 
                 156, 155, 153, 154 
                 V3 directed × V1N2 directed/CD4BS 
               
               
                 21 
                 164, 163, 161, 162 
                 MPER × CD4BS/V1/V2 directed 
               
               
                 22 
                 172, 171, 169, 170 
                 CD4BS × MPER/V1/V2 directed 
               
               
                 23 
                 180, 179, 177, 178 
                 CD4BS × V1/V2 directed/MPER 
               
               
                 24 
                 188, 187, 185, 186 
                 V1/V2 directed × CD4BS/MPER 
               
               
                 25 
                 196, 195, 193, 194 
                 MPER × V1/V2 directed/CD4BS 
               
               
                 26 
                 204, 203, 201, 202 
                 MPER × V1/V2 directed/CD4BS 
               
               
                 27 
                 212, 211, 209, 210 
                 MPER × V1/V2 directed/CD4BS 
               
               
                 28 
                 220, 219, 217, 218 
                 MPER × V1/V2 directed/CD4BS 
               
               
                 29 
                 228, 227, 225, 226 
                 MPER × V1/V2 directed/CD4BS 
               
               
                 30 
                 235, 234, 232, 233 
                 MPER × V1/V2 directed/CD4BS 
               
               
                 31 
                 243, 242, 240, 241 
                 MPER × V1/V2 directed/CD4BS 
               
               
                 32 
                 305, 304, 302, 303 
                 CD28 × CD3/CD4BS 
               
               
                 33 
                 313, 312, 310, 311 
                 CD28 × CD3/CD4BS 
               
               
                 34 
                 321, 320, 318, 319 
                 CD28 × CD3/V1/V2 directed 
               
               
                 35 
                 329, 328, 326, 327 
                 CD28 × CD3/V1/V2 directed 
               
               
                 36 
                 337, 336, 334, 335 
                 CD28 × CD3/CD4BS 
               
               
                 37 
                 345, 344, 342, 343 
                 CD28 × CD3/CD4BS 
               
               
                 38 
                 353, 352, 350, 351 
                 CD4BS × CD3/CD28 
               
               
                 39 
                 361, 360, 358, 359 
                 CD4BS × CD3/CD28 
               
               
                 40 
                 369, 368, 366, 367 
                 CD3 × CD4BS/CD28 
               
               
                 41 
                 377, 376, 374, 375 
                 CD3 × CD4BS/CD28 
               
               
                 42 
                 385, 384, 382, 383 
                 CD4BS × CD3/CD28 
               
               
                 43 
                 393, 392, 390, 391 
                 CD4BS × CD3/CD28 
               
               
                 44 
                 401, 400, 398, 399 
                 CD3 × CD4BS/CD28 
               
               
                 45 
                 409, 408, 406, 407 
                 CD3 × CD4BS/CD28 
               
               
                 46 
                 417, 416, 414, 415 
                 V1/V2 directed × CD3/CD28 
               
               
                 47 
                 425, 424, 422, 423 
                 V1/V2 directed × CD3/CD28 
               
               
                 48 
                 433, 432, 430, 431 
                 CD3 × V1/V2 directed/CD28 
               
               
                 49 
                 441, 440, 438, 439 
                 CD3 × V1/V2 directed/CD28 
               
               
                 50 
                 449, 448, 446, 447 
                 V1/V2 directed × CD3/CD28 
               
               
                 51 
                 457, 456, 454, 455 
                 V1/V2 directed × CD3/CD28 
               
               
                 52 
                 465, 464, 462, 463 
                 CD3 × V1/V2 directed/CD28 
               
               
                 53 
                 473, 472, 470, 471 
                 CD3 × V1/V2 directed/CD28 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
               
                   
               
               
                 Heavy and light chain sequences of binding proteins. CDR sequences are 
               
               
                 bolded and italicized. 
               
               
                   
               
             
            
               
                 Binding Protein 1 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsggqmkkpgesmriscrasgyefi  wirlapgkrpewmg   
                 SEQ ID NO: 1 
               
               
                   
                    rvtmtrdvysdtaflelrsltvddtavyfctr   
                   
               
               
                   
                    wgrgtpvivss astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn   
                   
               
               
                   
                 
                   sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve 
                 
                   
               
               
                   
                 
                   pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp 
                 
                   
               
               
                   
                 
                   evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs 
                 
                   
               
               
                   
                 
                   nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave 
                 
                   
               
               
                   
                 
                   wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhsh 
                 
                   
               
               
                   
                 
                   ytqkslslspg 
                 
                   
               
               
                   
               
               
                 Light chain A 
                 Eivltqspgtlslspgetaiiscr  wyqqrpgqaprlviy  gipd 
                 SEQ ID NO: 2 
               
               
                   
                 rfsgsrwgpdynltisnlesgdfgvyyc  fgqgtkvqvdikr tvaapsvfif   
                   
               
               
                   
                 
                   ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdst 
                 
                   
               
               
                   
                 
                   yslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Evrlvesggglvkpggslrlscsas  mtwvrqppgkglewvgr   
                 SEQ ID NO: 3 
               
               
                   
                    dyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar   
                   
               
               
                   
                    wgqgtlvivssdkthtqvhilqsgpevrkpgtsvkvsckapg 
                   
               
               
                   
                 ntlktydlhwvrsvpgqglqwmgwishegdkkviverfkakvtidwdrstnta 
                   
               
               
                   
                 ylqlsgltsgdtavyy    gq 
                   
               
               
                   
                 gtavtvssdkthtastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns 
                   
               
               
                   
                 galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep 
                   
               
               
                   
                 kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvdvshedpe 
                   
               
               
                   
                 vkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs 
                   
               
               
                   
                 nkalpapiektiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhsh 
                   
               
               
                   
                 ytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 Dfvltqsphslsvtpgesasisckss  lawyvqkpgrspqlliy   
                 SEQ ID NO: 4 
               
               
                   
                    srasgvpdrfsgsgsdkdftlkisrvetedvgtyy  gqgtkvdik 
                   
               
               
                   
                 dktht 
                   
               
               
                   
                 aseltqdpaysvalkqvtitc  wyqkkpgqapvllfy   
                   
               
               
                   
                 gipdrfsgsasgnrasltitgaqaedeadyyc  fgggtkltvldkth 
                   
               
               
                   
                 trtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqes 
                   
               
               
                   
                 vteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
            
           
           
               
            
               
                   
               
               
                 Binding Protein 1 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgc 
                 SEQ ID NO: 5 
               
               
                   
                 ggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatc 
                   
               
               
                   
                 agactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcg 
                   
               
               
                   
                 gagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgt 
                   
               
               
                   
                 gtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgt 
                   
               
               
                   
                 gtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcactggg 
                   
               
               
                   
                 gcagaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcgtgttc 
                   
               
               
                   
                 cctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctgcct 
                   
               
               
                   
                 cgtgaaggactactacccgagcccgtgaccgtgtcctggaattctggcgccctgac 
                   
               
               
                   
                 cagcggcgtgcacaccmccagctgtgctgcagtccagcggcctgtacagcctgag 
                   
               
               
                   
                 cagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaacgt 
                   
               
               
                   
                 gaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagagctg 
                   
               
               
                   
                 cgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcccttc 
                   
               
               
                   
                 cgtgacctgaccccccaaagcccaaggacaccctgatgatcagccggacccccg 
                   
               
               
                   
                 aagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttcaatt 
                   
               
               
                   
                 ggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagaggaac 
                   
               
               
                   
                 agtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactgg 
                   
               
               
                   
                 ctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccccat 
                   
               
               
                   
                 cgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtgcac 
                   
               
               
                   
                 actgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgtgcc 
                   
               
               
                   
                 gtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggccagcc 
                   
               
               
                   
                 cgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct 
                   
               
               
                   
                 ggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgctgcacgaggccctgcacagccactacacccagaagtccctgagcctg 
                   
               
               
                   
                 agccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 Gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag 
                 SEQ ID NO: 6 
               
               
                   
                 ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag 
                   
               
               
                   
                 gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg 
                   
               
               
                   
                 aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatcag 
                   
               
               
                   
                 caacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagacttcgg 
                   
               
               
                   
                 ccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtg 
                   
               
               
                   
                 ttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcc 
                   
               
               
                   
                 tgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc 
                   
               
               
                   
                 ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactc 
                   
               
               
                   
                 cacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac 
                   
               
               
                   
                 aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga 
                   
               
               
                   
                 gcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 7 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                   
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc 
                   
               
               
                   
                 gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa 
                   
               
               
                   
                 cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca 
                   
               
               
                   
                 cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc 
                   
               
               
                   
                 actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca 
                   
               
               
                   
                 cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac 
                   
               
               
                   
                 tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg 
                   
               
               
                   
                 ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc 
                   
               
               
                   
                 cctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagca 
                   
               
               
                   
                 acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac 
                   
               
               
                   
                 accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc 
                   
               
               
                   
                 tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt 
                   
               
               
                   
                 gacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctg 
                   
               
               
                   
                 tcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagca 
                   
               
               
                   
                 gcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaag 
                   
               
               
                   
                 gtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgc 
                   
               
               
                   
                 ccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaag 
                   
               
               
                   
                 gacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgag 
                   
               
               
                   
                 ccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataa 
                   
               
               
                   
                 tgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagc 
                   
               
               
                   
                 gtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggt 
                   
               
               
                   
                 ctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg 
                   
               
               
                   
                 cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca 
                   
               
               
                   
                 agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt 
                   
               
               
                   
                 ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt 
                   
               
               
                   
                 gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag 
                   
               
               
                   
                 gtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcca 
                   
               
               
                   
                 ctacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg 
                 SEQ ID NO: 8 
               
               
                   
                 ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                   
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc 
                   
               
               
                   
                 cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg 
                   
               
               
                   
                 tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc 
                   
               
               
                   
                 aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc 
                   
               
               
                   
                 actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc 
                   
               
               
                   
                 ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa 
                   
               
               
                   
                 caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc 
                   
               
               
                   
                 cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc 
                   
               
               
                   
                 ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc 
                   
               
               
                   
                 gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac 
                   
               
               
                   
                 ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact 
                   
               
               
                   
                 tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg 
                   
               
               
                   
                 gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc 
                   
               
               
                   
                 tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc 
                   
               
               
                   
                 ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggg 
                   
               
               
                   
                 gcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 2 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqts  lfwfrqapgrglewvgw   
                 SEQ ID NO: 9 
               
               
                   
                    nfgggfrdrvtltrdvyreiaymdirglkpddtavyycar   
                   
               
               
                   
                    wgqgttvvvsa astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns   
                   
               
               
                   
                 
                   galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep 
                 
                   
               
               
                   
                 
                   kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe 
                 
                   
               
               
                   
                 
                   vkfnwyvdgvevhnaktkpreeqynstyrvvsyltvlhqdwlngkeykckvsn 
                 
                   
               
               
                   
                 
                   kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew 
                 
                   
               
               
                   
                 
                   esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhshyt 
                 
                   
               
               
                   
                 
                   qkslslspg 
                 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsysigdrvtincqts  lhwyqhkpgrapkllihhtssved 
                 SEQ ID NO: 
               
               
                   
                 gvpsrfsgsgf  fnltisdlqaddiatyyc  fgrgsrlhikr tvaapsvfifpp   
                 10 
               
               
                   
                 
                   sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl 
                 
                   
               
               
                   
                 
                   sstltlskadyekhkvyacevthqglsspvtksfnrgec 
                 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv 
                 SEQ ID NO: 
               
               
                   
                 gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 
                 11 
               
               
                   
                 tgkyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevrk 
                   
               
               
                   
                 pgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkviv 
                   
               
               
                   
                 erfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalyddd 
                   
               
               
                   
                 galnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskst 
                   
               
               
                   
                 sggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvt 
                   
               
               
                   
                 vpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellgg 
                   
               
               
                   
                 psvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhn 
                   
               
               
                   
                 aktkpreeqynstyrvvsvltylhqdwlngkeykckvsnkalpapiektis 
                   
               
               
                   
                 kakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngq 
                   
               
               
                   
                 pennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhshyt 
                   
               
               
                   
                 qkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass 
                 SEQ ID NO: 
               
               
                   
                 rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikd 
                 12 
               
               
                   
                 kthtaseltqdpaysvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnr 
                   
               
               
                   
                 psgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldk 
                   
               
               
                   
                 thtrtvaapsvfifppsdeqlksgtasvvcll1nnfypreakvqwkvdnalqsgnsq 
                   
               
               
                   
                 esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 2 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 13 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg 
                   
               
               
                   
                 ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg 
                   
               
               
                   
                 cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg 
                   
               
               
                   
                 accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag 
                   
               
               
                   
                 ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc 
                   
               
               
                   
                 cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc 
                   
               
               
                   
                 ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca 
                   
               
               
                   
                 attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg 
                   
               
               
                   
                 aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac 
                   
               
               
                   
                 tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc 
                   
               
               
                   
                 catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg 
                   
               
               
                   
                 cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt 
                   
               
               
                   
                 gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct 
                   
               
               
                   
                 tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctgag 
                   
               
               
                   
                 cctgagccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt 
                 SEQ ID NO: 
               
               
                   
                 gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 
                 14 
               
               
                   
                 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga 
                   
               
               
                   
                 tggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccat 
                   
               
               
                   
                 cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc 
                   
               
               
                   
                 ggcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcat 
                   
               
               
                   
                 cttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct 
                   
               
               
                   
                 gaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg 
                   
               
               
                   
                 cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccac 
                   
               
               
                   
                 ctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag 
                   
               
               
                   
                 gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt 
                   
               
               
                   
                 caaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 15 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc 
                   
               
               
                   
                 gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa 
                   
               
               
                   
                 cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca 
                   
               
               
                   
                 cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc 
                   
               
               
                   
                 actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca 
                   
               
               
                   
                 cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac 
                   
               
               
                   
                 tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg 
                   
               
               
                   
                 ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc 
                   
               
               
                   
                 cctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagca 
                   
               
               
                   
                 acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac 
                   
               
               
                   
                 accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc 
                   
               
               
                   
                 tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt 
                   
               
               
                   
                 gacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctg 
                   
               
               
                   
                 tcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagca 
                   
               
               
                   
                 gcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaag 
                   
               
               
                   
                 gtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgc 
                   
               
               
                   
                 ccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaag 
                   
               
               
                   
                 gacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgag 
                   
               
               
                   
                 ccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataa 
                   
               
               
                   
                 tgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagc 
                   
               
               
                   
                 gtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggt 
                   
               
               
                   
                 ctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg 
                   
               
               
                   
                 cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca 
                   
               
               
                   
                 agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt 
                   
               
               
                   
                 ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt 
                   
               
               
                   
                 gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag 
                   
               
               
                   
                 gtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcca 
                   
               
               
                   
                 ctacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg 
                 SEQ ID NO: 
               
               
                   
                 ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                 16 
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc 
                   
               
               
                   
                 cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg 
                   
               
               
                   
                 tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc 
                   
               
               
                   
                 aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc 
                   
               
               
                   
                 actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc 
                   
               
               
                   
                 ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa 
                   
               
               
                   
                 caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc 
                   
               
               
                   
                 cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc 
                   
               
               
                   
                 ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc 
                   
               
               
                   
                 gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac 
                   
               
               
                   
                 ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact 
                   
               
               
                   
                 tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg 
                   
               
               
                   
                 gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc 
                   
               
               
                   
                 tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc 
                   
               
               
                   
                 ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggg 
                   
               
               
                   
                 gcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 3 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpqy 
                 SEQ ID NO: 
               
               
                   
                 gavnfggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswalda 
                 17 
               
               
                   
                 wgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsg 
                   
               
               
                   
                 altsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk 
                   
               
               
                   
                 scdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpev 
                   
               
               
                   
                 kfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnk 
                   
               
               
                   
                 alpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavewe 
                   
               
               
                   
                 sngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhshytq 
                   
               
               
                   
                 kslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                 SEQ ID NO: 
               
               
                   
                 gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsflhikrtvaapsvfifpp 
                 18 
               
               
                   
                 sdeqlksgtasvvclinnfypreakvqwkvdnalqsgnsqesvteqdskdstysl 
                   
               
               
                   
                 sstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwm 
                 SEQ ID NO: 
               
               
                   
                 gwishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakg 
                 19 
               
               
                   
                 skhrildyalydddgalnwavdvdylsnlefwgqgtavtvssdkthtevrl 
                   
               
               
                   
                 vesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgritg 
                   
               
               
                   
                 pgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartgky 
                   
               
               
                   
                 ydfwsgyppgeeyfqdwgqgtlvivssdkthtastkgpsvfplapsskst 
                   
               
               
                   
                 sggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvt 
                   
               
               
                   
                 vpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellgg 
                   
               
               
                   
                 psvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhn 
                   
               
               
                   
                 aktkpreeqynstyrvvsyltvlhqdwlngkeykckvsnkalpapiektis 
                   
               
               
                   
                 kakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngq 
                   
               
               
                   
                 pennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhshyt 
                   
               
               
                   
                 qkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsg 
                 SEQ ID NO: 
               
               
                   
                 ipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtd 
                 20 
               
               
                   
                 fvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr 
                   
               
               
                   
                 asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdk 
                   
               
               
                   
                 thtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq 
                   
               
               
                   
                 esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 3 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 21 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg 
                   
               
               
                   
                 ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg 
                   
               
               
                   
                 cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg 
                   
               
               
                   
                 accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag 
                   
               
               
                   
                 ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc 
                   
               
               
                   
                 cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc 
                   
               
               
                   
                 ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca 
                   
               
               
                   
                 attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg 
                   
               
               
                   
                 aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac 
                   
               
               
                   
                 tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc 
                   
               
               
                   
                 catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg 
                   
               
               
                   
                 cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt 
                   
               
               
                   
                 gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct 
                   
               
               
                   
                 tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctgag 
                   
               
               
                   
                 cctgagccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt 
                 SEQ ID NO: 
               
               
                   
                 gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 
                 22 
               
               
                   
                 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga 
                   
               
               
                   
                 tggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccat 
                   
               
               
                   
                 cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc 
                   
               
               
                   
                 ggcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcat 
                   
               
               
                   
                 cttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct 
                   
               
               
                   
                 gaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg 
                   
               
               
                   
                 cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccac 
                   
               
               
                   
                 ctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag 
                   
               
               
                   
                 gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt 
                   
               
               
                   
                 caaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctc 
                 SEQ ID NO: 
               
               
                   
                 tgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctg 
                 23 
               
               
                   
                 cactgggtgcgcagcgtgccaggacagggactgcagtggatgggctggat 
                   
               
               
                   
                 cagccacgagggcgacaagaaagtgatcgtggaacggttcaaggccaaag 
                   
               
               
                   
                 tgaccatcgactgggacagaagcaccaacaccgcctacctgcagctgagcg 
                   
               
               
                   
                 gcctgacctctggcgataccgccgtgtactactgcgccaagggcagcaagc 
                   
               
               
                   
                 accggctgagagactacgccctgtacgacgatgacggcgccctgaactgg 
                   
               
               
                   
                 gccgtggatgtggactacctgagcaacctggaattctggggccagggcaca 
                   
               
               
                   
                 gccgtgaccgtgtcatctgacaaaacccataccgaggttagactggtggagt 
                   
               
               
                   
                 caggaggggggcttgtgaagcccggtgggtctctccgcctgagctgttctgc 
                   
               
               
                   
                 ctccggctttgatttcgataacgcctggatgacctgggtcaggcagcctccag 
                   
               
               
                   
                 gtaagggactggagtgggtgggaagaatcacaggtccaggcgagggctgg 
                   
               
               
                   
                 tccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaa 
                   
               
               
                   
                 taccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccg 
                   
               
               
                   
                 gatattacttctgtgccagaacaggcaaatactacgacttctggtccggctatc 
                   
               
               
                   
                 cccctggcgaggaatattttcaagactggggtcagggaacccttgttatcgtgt 
                   
               
               
                   
                 cctccgataagacccacaccgcttccaccaagggcccatcggicttccccct 
                   
               
               
                   
                 ggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcct 
                   
               
               
                   
                 ggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgc 
                   
               
               
                   
                 cctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactct 
                   
               
               
                   
                 actccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccaga 
                   
               
               
                   
                 cctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaaga 
                   
               
               
                   
                 aagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagc 
                   
               
               
                   
                 acctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaag 
                   
               
               
                   
                 gacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacg 
                   
               
               
                   
                 tgagccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtgga 
                   
               
               
                   
                 ggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgt 
                   
               
               
                   
                 accgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaa 
                   
               
               
                   
                 ggagtacaagtgcaaggictccaacaaagccctcccagcccccatcgagaa 
                   
               
               
                   
                 aaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccct 
                   
               
               
                   
                 gcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcct 
                   
               
               
                   
                 ggtaaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgg 
                   
               
               
                   
                 gcagccggagaacaactacaagaccacgcctcccgtgctggactccgacg 
                   
               
               
                   
                 gctccttcttcctctactcaaaactcaccgtggacaagagcaggtggcagcag 
                   
               
               
                   
                 gggaacgtcttctcatgctccgtgctgcatgaggctctgcacagccactacac 
                   
               
               
                   
                 gcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactgtgact 
                 SEQ ID NO: 
               
               
                   
                 attacttgccgaggcgactcactgcggagccactacgcttcctggtatcagaagaaa 
                 24 
               
               
                   
                 cccggccaggcacctgtgctgctgttctacggaaagaacaataggccatctggcatc 
                   
               
               
                   
                 cccgaccgcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggc 
                   
               
               
                   
                 gcccaggctgaggacgaagccgattactattgcagctcccgggataagagcggctc 
                   
               
               
                   
                 cagactgagcgtgttcggaggaggaactaaactgaccgtcctcgacaaaacccata 
                   
               
               
                   
                 ccgacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagc 
                   
               
               
                   
                 gccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaact 
                   
               
               
                   
                 acctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctgg 
                   
               
               
                   
                 ccagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaa 
                   
               
               
                   
                 ggacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactact 
                   
               
               
                   
                 gtatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacat 
                   
               
               
                   
                 caaggataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccacct 
                   
               
               
                   
                 agcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttc 
                   
               
               
                   
                 tacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggc 
                   
               
               
                   
                 aacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg 
                   
               
               
                   
                 agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcct 
                   
               
               
                   
                 gcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgggg 
                   
               
               
                   
                 cgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 4 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlk 
                 SEQ ID NO: 
               
               
                   
                 prggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwodf 
                 25 
               
               
                   
                 ehwgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn 
                   
               
               
                   
                 sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve 
                   
               
               
                   
                 pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp 
                   
               
               
                   
                 evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs 
                   
               
               
                   
                 nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealh 
                   
               
               
                   
                 nhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 Eivltqspgtlslspgetaiiscrtsqygslawyqqrpgqaprlviysgstraagipdr 
                 SEQ ID NO: 
               
               
                   
                 fsgsrwgpdynltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifp 
                 26 
               
               
                   
                 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv 
                 SEQ ID NO: 
               
               
                   
                 gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfca 
                 27 
               
               
                   
                 rtgkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevr 
                   
               
               
                   
                 kpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkv 
                   
               
               
                   
                 iverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalyd 
                   
               
               
                   
                 ddgalnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapss 
                   
               
               
                   
                 kstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss 
                   
               
               
                   
                 vvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapell 
                   
               
               
                   
                 ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgve 
                   
               
               
                   
                 vhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapie 
                   
               
               
                   
                 ktiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewes 
                   
               
               
                   
                 ngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmheal 
                   
               
               
                   
                 hnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas 
                 SEQ ID NO: 
               
               
                   
                 srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik 
                 28 
               
               
                   
                 dkthtasetlqdpavsvalkqtvtitcrgdskshyaswyqkkpgqapvllfygkn 
                   
               
               
                   
                 nrpsgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvl 
                   
               
               
                   
                 dkthtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgn 
                   
               
               
                   
                 sqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 4 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgc 
                 SEQ ID NO: 
               
               
                   
                 ggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatc 
                 29 
               
               
                   
                 agactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcg 
                   
               
               
                   
                 gagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgt 
                   
               
               
                   
                 gtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgt 
                   
               
               
                   
                 gtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcactggg 
                   
               
               
                   
                 gcagaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcgtgttc 
                   
               
               
                   
                 cctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctgcct 
                   
               
               
                   
                 cgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctgac 
                   
               
               
                   
                 cagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctgag 
                   
               
               
                   
                 cagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaacgt 
                   
               
               
                   
                 gaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagagctg 
                   
               
               
                   
                 cgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcccttc 
                   
               
               
                   
                 cgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccg 
                   
               
               
                   
                 aagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttcaatt 
                   
               
               
                   
                 ggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagaggaac 
                   
               
               
                   
                 agtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactgg 
                   
               
               
                   
                 ctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccccat 
                   
               
               
                   
                 cgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtgcac 
                   
               
               
                   
                 actgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgtgcc 
                   
               
               
                   
                 gtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggccagcc 
                   
               
               
                   
                 cgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct 
                   
               
               
                   
                 ggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgagcctg 
                   
               
               
                   
                 agccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 Gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag 
                 SEQ ID NO: 
               
               
                   
                 ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag 
                 30 
               
               
                   
                 gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg 
                   
               
               
                   
                 aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatcag 
                   
               
               
                   
                 caacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcgg 
                   
               
               
                   
                 ccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtg 
                   
               
               
                   
                 ttcatcacccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcc 
                   
               
               
                   
                 tgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc 
                   
               
               
                   
                 ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactc 
                   
               
               
                   
                 cacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac 
                   
               
               
                   
                 aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga 
                   
               
               
                   
                 gcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgactgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 31 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctgg 
                   
               
               
                   
                 cgaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa 
                   
               
               
                   
                 acccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggc 
                   
               
               
                   
                 acctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctg 
                   
               
               
                   
                 cactgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcc 
                   
               
               
                   
                 acgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcga 
                   
               
               
                   
                 ctgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggc 
                   
               
               
                   
                 gataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacg 
                   
               
               
                   
                 ccctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagc 
                   
               
               
                   
                 aacctggaattctggggccagggcacagccgtgaccgtgtcatctgataagaccca 
                   
               
               
                   
                 caccgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcac 
                   
               
               
                   
                 ctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccgg 
                   
               
               
                   
                 tgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggct 
                   
               
               
                   
                 gtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagc 
                   
               
               
                   
                 agcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaa 
                   
               
               
                   
                 ggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtg 
                   
               
               
                   
                 cccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaa 
                   
               
               
                   
                 ggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtga 
                   
               
               
                   
                 gccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcata 
                   
               
               
                   
                 atgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcag 
                   
               
               
                   
                 cgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaagg 
                   
               
               
                   
                 tctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg 
                   
               
               
                   
                 cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca 
                   
               
               
                   
                 agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt 
                   
               
               
                   
                 ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt 
                   
               
               
                   
                 gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag 
                   
               
               
                   
                 gtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcca 
                   
               
               
                   
                 ctacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg 
                 SEQ ID NO: 
               
               
                   
                 ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                 32 
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc 
                   
               
               
                   
                 cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg 
                   
               
               
                   
                 tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc 
                   
               
               
                   
                 aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc 
                   
               
               
                   
                 actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc 
                   
               
               
                   
                 ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa 
                   
               
               
                   
                 caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc 
                   
               
               
                   
                 cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc 
                   
               
               
                   
                 ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc 
                   
               
               
                   
                 gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac 
                   
               
               
                   
                 ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact 
                   
               
               
                   
                 tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg 
                   
               
               
                   
                 gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc 
                   
               
               
                   
                 tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc 
                   
               
               
                   
                 ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggg 
                   
               
               
                   
                 gcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 5 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlk 
                 SEQ ID NO: 
               
               
                   
                 prggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdf 
                 33 
               
               
                   
                 ehwgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns 
                   
               
               
                   
                 galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep 
                   
               
               
                   
                 kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe 
                   
               
               
                   
                 vkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsn 
                   
               
               
                   
                 kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew 
                   
               
               
                   
                 esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhnh 
                   
               
               
                   
                 ytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 Eivltqspgtlslspgetaiiscrtsqygslawyqqrpgqaprlviysgstraagipdr 
                 SEQ ID NO: 
               
               
                   
                 fsgsrwgpdynilisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifp 
                 34 
               
               
                   
                 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv 
                 SEQ ID NO: 
               
               
                   
                 gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 
                 35 
               
               
                   
                 tgkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqmqlqesgpglv 
                   
               
               
                   
                 kpsetlsltcsvsgasisdsywswirrspgkglewigyvhksgdtnyspsl 
                   
               
               
                   
                 ksrvnlsldtsknqvslslvaataadsgkyycartlhgrriygivafnewfty 
                   
               
               
                   
                 fymdvvvgngtqvtvssdkthtastkgpsvfplapsskstsggtaalgclvk 
                   
               
               
                   
                 dyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyic 
                   
               
               
                   
                 nvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkd 
                   
               
               
                   
                 tlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqyns 
                   
               
               
                   
                 tyrvvsyltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqv 
                   
               
               
                   
                 ytlppcrdeltknqvslwclvkgfypsdiavewesngqpennykttppvl 
                   
               
               
                   
                 dsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 Sdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsg 
                 SEQ ID NO: 
               
               
                   
                 spdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtaselt 
                 36 
               
               
                   
                 qdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgipdrf 
                   
               
               
                   
                 sgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtvaap 
                   
               
               
                   
                 svfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds 
                   
               
               
                   
                 kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 5 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatg 
                 SEQ ID NO: 
               
               
                   
                 cggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggat 
                 37 
               
               
                   
                 cagactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggc 
                   
               
               
                   
                 ggagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggac 
                   
               
               
                   
                 gtgtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgcc 
                   
               
               
                   
                 gtgtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcactgg 
                   
               
               
                   
                 ggcagaggcacccctgtgatcgtgtcaagc 
                   
               
               
                   
                 gcgtcgaccaagggccccagcgtgttccctctggcccctagcagcaagagcacatc 
                   
               
               
                   
                 tggcggaacagccgccctgggctgcctcgtgaaggactactttcccgagcccgtga 
                   
               
               
                   
                 ccgtgtcctggaattctggcgccctgaccagcggcgtgcacacctttccagctgtgct 
                   
               
               
                   
                 gcagtccagcggcctgtacagcctgagcagcgtcgtgacagtgcccagcagctctc 
                   
               
               
                   
                 tgggcacccagacctacatctgcaacgtgaaccacaagcccagcaacaccaaggt 
                   
               
               
                   
                 ggacaagaaggtggaacccaagagctgcgacaagacccacacctgtcccccttgt 
                   
               
               
                   
                 cctgcccccgaactgctgggaggcccttccgtgttcctgttccccccaaagcccaag 
                   
               
               
                   
                 gacaccctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtc 
                   
               
               
                   
                 ccacgaggaccctgaagtgaagttcaattggtacgtggacggcgtggaagtgcaca 
                   
               
               
                   
                 acgccaagaccaagccaagagaggaacagtacaacagcacctaccgggtggtgtc 
                   
               
               
                   
                 cgtgctgaccgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaag 
                   
               
               
                   
                 gtgtccaacaaggccctgcctgcccccatcgagaaaaccatcagcaaggccaagg 
                   
               
               
                   
                 gccagccccgcgaaccccaggtgtgcacactgcccccaagcagggacgagctga 
                   
               
               
                   
                 ccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccctccgatatcg 
                   
               
               
                   
                 ccgtggaatgggagagcaacggccagcccgagaacaactacaagaccacccccc 
                   
               
               
                   
                 ctgtgctggacagcgacggctcattcttcctggtgtccaagctgacagtggacaagtc 
                   
               
               
                   
                 ccggtggcagcagggcaacgtgttcagctgctccgtgatgcacgaggccctgcaca 
                   
               
               
                   
                 accactacacccagaagtccctgagcctgagccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 Gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag 
                 SEQ ID NO: 
               
               
                   
                 ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag 
                 38 
               
               
                   
                 gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg 
                   
               
               
                   
                 aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatcag 
                   
               
               
                   
                 caacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcgg 
                   
               
               
                   
                 ccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtg 
                   
               
               
                   
                 ttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcc 
                   
               
               
                   
                 tgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc 
                   
               
               
                   
                 ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactc 
                   
               
               
                   
                 cacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac 
                   
               
               
                   
                 aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga 
                   
               
               
                   
                 gcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 39 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctgg 
                   
               
               
                   
                 cgaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa 
                   
               
               
                   
                 acccatacccagatgcagctgcaggagagcggccctggactcgtgaagcccagcg 
                   
               
               
                   
                 agaccctgagcctgacatgcagcgtgagcggcgccagcatcagcgacagctactg 
                   
               
               
                   
                 gagctggatcaggaggagccctggcaagggcctggagtggatcggctacgtgcac 
                   
               
               
                   
                 aagagcggcgacaccaactacagcccctccctgaagtccagggtgaacctgtccct 
                   
               
               
                   
                 ggacaccagcaagaaccaggtgagcctgtccctggtggctgccacagctgctgac 
                   
               
               
                   
                 agcggcaagtactactgtgccaggaccctgcacggcaggaggatctacggcatcgt 
                   
               
               
                   
                 ggccttcaacgagtggttcacctacttctacatggacgtgtggggcaacggcaccca 
                   
               
               
                   
                 ggtgaccgtgagctccgataagacccacaccgcttccaccaagggcccatcggtctt 
                   
               
               
                   
                 ccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgc 
                   
               
               
                   
                 ctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccct 
                   
               
               
                   
                 gaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctc 
                   
               
               
                   
                 agcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatctt 
                   
               
               
                   
                 gtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggacc 
                   
               
               
                   
                 gtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccct 
                   
               
               
                   
                 gaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaa 
                   
               
               
                   
                 ctggtatgttgacggcgtggaggtgcataatgccaagacaaagccgcgggaggag 
                   
               
               
                   
                 cagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactg 
                   
               
               
                   
                 gctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagccccca 
                   
               
               
                   
                 tcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacac 
                   
               
               
                   
                 cctgcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctggt 
                   
               
               
                   
                 aaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccg 
                   
               
               
                   
                 gagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctct 
                   
               
               
                   
                 actcaaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgc 
                   
               
               
                   
                 tccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctc 
                   
               
               
                   
                 cgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 tccgacatcagcgtggcccccggagagacagccaggatctcctgcggcgagaaga 
                 SEQ ID NO: 
               
               
                   
                 gcctgggaagcagggctgtgcagtggtaccaacacagggccggacaggctccca 
                 40 
               
               
                   
                 gcctgatcatctacaacaaccaggacaggcccagcggcatccctgagaggttcagc 
                   
               
               
                   
                 ggaagccccgacagccccttcggaaccacagccaccctgaccatcacaagcgtgg 
                   
               
               
                   
                 aagccggcgacgaggccgactactactgccacatctgggacagcagggtgcccac 
                   
               
               
                   
                 caagtgggtgtttggcggcggcaccaccctgaccgtgctggacaaaacccataccg 
                   
               
               
                   
                 catccgaactgactcaggaccctgccgtctctgtggcactgaagcagactgtgactat 
                   
               
               
                   
                 tacttgccgaggcgactcactgcggagccactacgcttcctggtatcagaagaaacc 
                   
               
               
                   
                 cggccaggcacctgtgctgctgttctacggaaagaacaataggccatctggcatccc 
                   
               
               
                   
                 cgaccgcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggcgc 
                   
               
               
                   
                 ccaggctgaggacgaagccgattactattgcagctcccgggataagagcggctcca 
                   
               
               
                   
                 gactgagcgtgttcggaggaggaactaaactgaccgtcctcgataagacccatacc 
                   
               
               
                   
                 cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaag 
                   
               
               
                   
                 tccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaa 
                   
               
               
                   
                 gtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagcgtg 
                   
               
               
                   
                 accgagcaggacagcaaggactccacctacagcctgagcagcaccctgacactga 
                   
               
               
                   
                 gcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagg 
                   
               
               
                   
                 gcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 6 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlk 
                 SEQ ID NO: 
               
               
                   
                 prggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdf 
                 41 
               
               
                   
                 ehwgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns 
                   
               
               
                   
                 galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep 
                   
               
               
                   
                 kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe 
                   
               
               
                   
                 vkfnwyvdgvevhnaktkpreeqynstyrwsvltvlhqdwlngkeykckvsn 
                   
               
               
                   
                 kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew 
                   
               
               
                   
                 esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhnh 
                   
               
               
                   
                 ytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 Eivltqspgtlslspgetaiiscrtsqygslawyqqrpgqaprlviysgstraagipdr 
                 SEQ ID NO: 
               
               
                   
                 fsgsrwgpdynltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifp 
                 42 
               
               
                   
                 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lssltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvhltqsgpevrkpgtsykysckapgntlktydlhwyrsvpgqglqwm 
                 SEQ ID NO: 
               
               
                   
                 gwishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakg 
                 43 
               
               
                   
                 skhrlrdyalydddgalnwavdvdylsnlefwgqgtavtvssdkthtevrl 
                   
               
               
                   
                 vesggglykpggslrlscsasgfdfdnawmtwvrqppgkglewvgritg 
                   
               
               
                   
                 pgegwsvdyaesykgrftisrdntkntlylemnnvrtedtgyyfcartgky 
                   
               
               
                   
                 ydfwwgyppgeeyfqdwgqgtlvivssdkthtastkgpsvfplapsskst 
                   
               
               
                   
                 sggtaalgclykdyfpepytyswnsgaltsgvhtfpavlqssglyslssvvt 
                   
               
               
                   
                 vpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellgg 
                   
               
               
                   
                 psvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhn 
                   
               
               
                   
                 aktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektis 
                   
               
               
                   
                 kakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngq 
                   
               
               
                   
                 pennykttppvldsdgsfflyskltvdksrwqqgnyfscsvmhealhnhy 
                   
               
               
                   
                 tqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 Aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrps 
                 SEQ ID NO: 
               
               
                   
                 gipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldktht 
                 44 
               
               
                   
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass 
                   
               
               
                   
                 rasgvpdrfsgsgsdkdfdkisrvetedvgtyycmqgrespwtfgqgtkvdikd 
                   
               
               
                   
                 kthtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgns 
                   
               
               
                   
                 qesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 6 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgc 
                 SEQ ID NO: 
               
               
                   
                 ggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatc 
                 45 
               
               
                   
                 agactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcg 
                   
               
               
                   
                 gagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgt 
                   
               
               
                   
                 gtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgt 
                   
               
               
                   
                 gtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcactggg 
                   
               
               
                   
                 gcagaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcgtgttc 
                   
               
               
                   
                 cctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctgcct 
                   
               
               
                   
                 cgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctgac 
                   
               
               
                   
                 cagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctgag 
                   
               
               
                   
                 cagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaacgt 
                   
               
               
                   
                 gaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagagctg 
                   
               
               
                   
                 cgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcccttc 
                   
               
               
                   
                 cgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccg 
                   
               
               
                   
                 aagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttcaatt 
                   
               
               
                   
                 ggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagaggaac 
                   
               
               
                   
                 agtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactgg 
                   
               
               
                   
                 ctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccccat 
                   
               
               
                   
                 cgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtgcac 
                   
               
               
                   
                 actgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgtgcc 
                   
               
               
                   
                 gtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggccagcc 
                   
               
               
                   
                 cgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct 
                   
               
               
                   
                 ggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgagcctg 
                   
               
               
                   
                 agccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag 
                 SEQ ID NO: 
               
               
                   
                 ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag 
                 46 
               
               
                   
                 gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg 
                   
               
               
                   
                 aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatcag 
                   
               
               
                   
                 caacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcgg 
                   
               
               
                   
                 ccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtg 
                   
               
               
                   
                 ttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcc 
                   
               
               
                   
                 tgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc 
                   
               
               
                   
                 ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactc 
                   
               
               
                   
                 cacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac 
                   
               
               
                   
                 aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga 
                   
               
               
                   
                 gcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga 
                 SEQ ID NO: 
               
               
                   
                 aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 
                 47 
               
               
                   
                 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc 
                   
               
               
                   
                 gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca 
                   
               
               
                   
                 gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc 
                   
               
               
                   
                 cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac 
                   
               
               
                   
                 gacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaacctgg 
                   
               
               
                   
                 aattctggggccagggcacagccgtgaccgtgtcatctgacaaaacccataccgag 
                   
               
               
                   
                 gttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgcct 
                   
               
               
                   
                 gagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggcag 
                   
               
               
                   
                 cctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagggct 
                   
               
               
                   
                 ggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaata 
                   
               
               
                   
                 ccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggatatta 
                   
               
               
                   
                 cttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctggcga 
                   
               
               
                   
                 ggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgataagaccc 
                   
               
               
                   
                 acaccgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagca 
                   
               
               
                   
                 cctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccg 
                   
               
               
                   
                 gtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggc 
                   
               
               
                   
                 tgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagc 
                   
               
               
                   
                 agcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaa 
                   
               
               
                   
                 ggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtg 
                   
               
               
                   
                 cccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaa 
                   
               
               
                   
                 ggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtga 
                   
               
               
                   
                 gccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcata 
                   
               
               
                   
                 atgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcag 
                   
               
               
                   
                 cgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaagg 
                   
               
               
                   
                 tctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg 
                   
               
               
                   
                 cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca 
                   
               
               
                   
                 agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt 
                   
               
               
                   
                 ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt 
                   
               
               
                   
                 gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag 
                   
               
               
                   
                 gtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaacca 
                   
               
               
                   
                 ctacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 Gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagact 
                 SEQ ID NO: 
               
               
                   
                 gtgactattacttgccgaggcgactcactgcggagccactacgcttcctggta 
                 48 
               
               
                   
                 tcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaat 
                   
               
               
                   
                 aggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgag 
                   
               
               
                   
                 ccagtctgaccattaccggcgcccaggctgaggacgaagccgattactattg 
                   
               
               
                   
                 cagctcccgggataagagcggctccagactgagcgtgttcggaggaggaa 
                   
               
               
                   
                 ctaaactgaccgtcctcgacaaaacccataccgacttcgtgctgacccagag 
                   
               
               
                   
                 ccctcacagcctgagcgtgacacctggcgagagcgccagcatcagctgca 
                   
               
               
                   
                 agagcagccactccctgatccacggcgaccggaacaactacctggcttggt 
                   
               
               
                   
                 acgtgcagaagcccggcagatccccccagctgctgatctacctggccagca 
                   
               
               
                   
                 gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctac 
                   
               
               
                   
                 tactgtatgcagggcagagagagcccctggacctttggccagggcaccaag 
                   
               
               
                   
                 gtggacatcaaggataagacccatacccgtacggtggccgctcccagcgtg 
                   
               
               
                   
                 ttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgt 
                   
               
               
                   
                 gtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggt 
                   
               
               
                   
                 ggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcag 
                   
               
               
                   
                 gacagcaaggactccacctacagcctgagcagcaccctgacactgagcaa 
                   
               
               
                   
                 ggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagg 
                   
               
               
                   
                 gcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 7 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlk 
                 SEQ ID NO: 
               
               
                   
                 prggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdf 
                 49 
               
               
                   
                 ehwgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns 
                   
               
               
                   
                 galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep 
                   
               
               
                   
                 kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe 
                   
               
               
                   
                 vkfnwyvdgvevhnaktkpreeqynstyrvvsvltylhqdwlngkeykckvsn 
                   
               
               
                   
                 kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew 
                   
               
               
                   
                 esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhnh 
                   
               
               
                   
                 ytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 Eivltqspgtlslspgetaiiscrtsqygslawyqqrpgqaprlviysgstraagipdr 
                 SEQ ID NO: 
               
               
                   
                 fsgsrwgpdynltisnlesgclfgvyycqqyeffgqgtkvqvdikrtvaapsvfifp 
                 50 
               
               
                   
                 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 qmqlqesgpglvkpsetlsltcsvsgasisdsywswirrspgkglewigy 
                 SEQ ID NO: 
               
               
                   
                 vhksgdtnyspslksrvnlsldtsknqvslslvaataadsgkyycartlhgrr 
                 51 
               
               
                   
                 iygivafnewftyfymdvvvgngtqvtvssdkthtQvhltqsgpevrkpg 
                   
               
               
                   
                 tsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkviver 
                   
               
               
                   
                 fkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddga 
                   
               
               
                   
                 lnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskstsg 
                   
               
               
                   
                 gtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvp 
                   
               
               
                   
                 ssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggps 
                   
               
               
                   
                 vflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhna 
                   
               
               
                   
                 ktkpreeqynstyrvvsyltvlhqdwlngkeykckvsnkalpapiektisk 
                   
               
               
                   
                 akgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqp 
                   
               
               
                   
                 ennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhyt 
                   
               
               
                   
                 qkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas 
                 SEQ ID NO: 
               
               
                   
                 srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik 
                 52 
               
               
                   
                 dkthtsdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgip 
                   
               
               
                   
                 erfsgspdspfgttatltitsveagdeadyychiwdsrvptkwvfgggattltvldkth 
                   
               
               
                   
                 trtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqes 
                   
               
               
                   
                 vteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 7 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgc 
                 SEQ ID NO: 
               
               
                   
                 ggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatc 
                 53 
               
               
                   
                 agactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcg 
                   
               
               
                   
                 gagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgt 
                   
               
               
                   
                 gtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgt 
                   
               
               
                   
                 gtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcactggg 
                   
               
               
                   
                 gcagaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcgtgttc 
                   
               
               
                   
                 cctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctgcct 
                   
               
               
                   
                 cgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctgac 
                   
               
               
                   
                 cagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctgag 
                   
               
               
                   
                 cagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaacgt 
                   
               
               
                   
                 gaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagagctg 
                   
               
               
                   
                 cgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcccttc 
                   
               
               
                   
                 cgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccg 
                   
               
               
                   
                 aagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttcaatt 
                   
               
               
                   
                 ggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagaggaac 
                   
               
               
                   
                 agtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactgg 
                   
               
               
                   
                 ctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccccat 
                   
               
               
                   
                 cgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtgcac 
                   
               
               
                   
                 actgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgtgcc 
                   
               
               
                   
                 gtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggccagcc 
                   
               
               
                   
                 cgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct 
                   
               
               
                   
                 ggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgagcctg 
                   
               
               
                   
                 agccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag 
                 SEQ ID NO: 
               
               
                   
                 ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag 
                 54 
               
               
                   
                 gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg 
                   
               
               
                   
                 aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatcag 
                   
               
               
                   
                 caacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcgg 
                   
               
               
                   
                 ccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtg 
                   
               
               
                   
                 ttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcc 
                   
               
               
                   
                 tgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc 
                   
               
               
                   
                 ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactc 
                   
               
               
                   
                 cacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac 
                   
               
               
                   
                 aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga 
                   
               
               
                   
                 gcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 cagatgcagctgcaggagagcggccctggactcgtgaagcccagcgagaccctg 
                 SEQ ID NO: 
               
               
                   
                 agcctgacatgcagcgtgagcggcgccagcatcagcgacagctactggagctgga 
                 55 
               
               
                   
                 tcaggaggagccctggcaagggcctggagtggatcggctacgtgcacaagagcg 
                   
               
               
                   
                 gcgacaccaactacagcccctccctgaagtccagggtgaacctgtccctggacacc 
                   
               
               
                   
                 agcaagaaccaggtgagcctgtccctggtggctgccacagctgctgacagcggca 
                   
               
               
                   
                 agtactactgtgccaggaccctgcacggcaggaggatctacggcatcgtggccttca 
                   
               
               
                   
                 acgagtggttcacctacttctacatggacgtgtggggcaacggcacccaggtgacc 
                   
               
               
                   
                 gtgagctccgacaaaacccatacccaggtgcacctgacacagagcggacccgaag 
                   
               
               
                   
                 tgcggaagcctggcacctctgtgaaggtgtcctgcaaggcccctggcaacaccctg 
                   
               
               
                   
                 aaaacctacgacctgcactgggtgcgcagcgtgccaggacagggactgcagtgga 
                   
               
               
                   
                 tgggctggatcagccacgagggcgacaagaaagtgatcgtggaacggttcaaggc 
                   
               
               
                   
                 caaagtgaccatcgactgggacagaagcaccaacaccgcctacctgcagctgagc 
                   
               
               
                   
                 ggcctgacctctggcgataccgccgtgtactactgcgccaagggcagcaagcacc 
                   
               
               
                   
                 ggctgagagactacgccctgtacgacgatgacggcgccctgaactgggccgtgga 
                   
               
               
                   
                 tgtggactacctgagcaacctggaattctggggccagggcacagccgtgaccgtgt 
                   
               
               
                   
                 catctgataagacccacaccgcttccaccaagggcccatcggtcttccccctggcac 
                   
               
               
                   
                 cctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaagga 
                   
               
               
                   
                 ctacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcg 
                   
               
               
                   
                 tgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggt 
                   
               
               
                   
                 gaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcaca 
                   
               
               
                   
                 agcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaact 
                   
               
               
                   
                 cacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctc 
                   
               
               
                   
                 ttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgc 
                   
               
               
                   
                 gtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtatgttgac 
                   
               
               
                   
                 ggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagc 
                   
               
               
                   
                 acgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaag 
                   
               
               
                   
                 gagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccat 
                   
               
               
                   
                 ctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatgc 
                   
               
               
                   
                 cgggatgagctgaccaagaatcaagtcagcctgtggtgcctggtaaaaggcttctat 
                   
               
               
                   
                 cccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactac 
                   
               
               
                   
                 aagaccacgcctcccgtgctggactccgacggctccttcttcctctactcaaaactca 
                   
               
               
                   
                 ccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcat 
                   
               
               
                   
                 gaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 Gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgag 
                 SEQ ID NO: 
               
               
                   
                 agcgccagcatcagctgcaagagcagccactccctgatccacggcgaccg 
                 56 
               
               
                   
                 gaacaactacctggcttggtacgtgcagaagcccggcagatccccccagct 
                   
               
               
                   
                 gctgatctacctggccagcagcagagccagcggcgtgcccgatagattttct 
                   
               
               
                   
                 ggcagcggcagcgacaaggacttcaccctgaagatcagccgggtggaaac 
                   
               
               
                   
                 cgaggacgtgggcacctactactgtatgcagggcagagagagcccctgga 
                   
               
               
                   
                 cctttggccagggcaccaaggtggacatcaaggacaaaacccatacctccg 
                   
               
               
                   
                 acatcagcgtggcccccggagagacagccaggatctcctgcggcgagaag 
                   
               
               
                   
                 agcctgggaagcagggctgtgcagtggtaccaacacagggccggacagg 
                   
               
               
                   
                 ctcccagcctgatcatctacaacaaccaggacaggcccagcggcatccctg 
                   
               
               
                   
                 agaggttcagcggaagccccgacagccccttcggaaccacagccaccctg 
                   
               
               
                   
                 accatcacaagcgtggaagccggcgacgaggccgactactactgccacatc 
                   
               
               
                   
                 tgggacagcagggtgcccaccaagtgggtgtttggcggcggcaccaccct 
                   
               
               
                   
                 gaccgtgctggataagacccatacccgtacggtggccgctcccagcgtgttc 
                   
               
               
                   
                 atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgt 
                   
               
               
                   
                 gcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtgg 
                   
               
               
                   
                 acaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcagga 
                   
               
               
                   
                 cagcaaggactccacctacagcctgagcagcaccctgacactgagcaagg 
                   
               
               
                   
                 ccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggc 
                   
               
               
                   
                 ctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 8 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq  
                 SEQ ID NO: 
               
               
                   
                 ygavnfgggfrdrvthrdvyreiaymdirglkpddtavyycardrsygdsswal 
                 57 
               
               
                   
                 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn 
                   
               
               
                   
                 sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve 
                   
               
               
                   
                 pkscdkthtcppcpapellggpsvflfppkpkddmisrtpevtcvvvdvshedp 
                   
               
               
                   
                 evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs 
                   
               
               
                   
                 nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhsh 
                   
               
               
                   
                 ytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 Yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                 SEQ ID NO: 
               
               
                   
                 gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 
                 58 
               
               
                   
                 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl 
                   
               
               
                   
                 sstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv 
                 SEQ ID NO: 
               
               
                   
                 gritgpgegwsvdyaesykgrftisrdntkntlylemnnvrtedtgyyfcar 
                 59 
               
               
                   
                 tgkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqvqlvesgggyv 
                   
               
               
                   
                 qpgtslrlscaasqfrfdgygmhwvrqapgkglewvasishdgikkyha 
                   
               
               
                   
                 ekvvvgrftisrdnskntlylqmnslrpedtalyycakdlredeceewwsd 
                   
               
               
                   
                 yydfgkqlpcaksrgglvgiadnwgqgtmvtvssdkthtastkgpsvfpl 
                   
               
               
                   
                 apsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly 
                   
               
               
                   
                 slssvvtypssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpa 
                   
               
               
                   
                 pellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd 
                   
               
               
                   
                 gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalp 
                   
               
               
                   
                 apiektiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflyskltvdksrwqqgnyfscsvmh 
                   
               
               
                   
                 ealhnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 Qsvltqppsysaapgqkvtiscsgntsnignnfvswyqqrpgrapqlliyetdkr 
                 SEQ ID NO: 
               
               
                   
                 psgipdrfsasksgtsgtlaitglqtgdeadyycatwaaslssarvfgtgtkvivldkt 
                 60 
               
               
                   
                 htasettqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrp 
                   
               
               
                   
                 sgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkt 
                   
               
               
                   
                 htrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqe 
                   
               
               
                   
                 svteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 8 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 61 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgt 
                   
               
               
                   
                 accgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgt 
                   
               
               
                   
                 gtactactgcgccagagacagaagctacggcgacagcagctgggctctggatgctt 
                   
               
               
                   
                 ggggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgt 
                   
               
               
                   
                 gttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggct 
                   
               
               
                   
                 gcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccct 
                   
               
               
                   
                 gaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcc 
                   
               
               
                   
                 tgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgc 
                   
               
               
                   
                 aacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaag 
                   
               
               
                   
                 agctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggagg 
                   
               
               
                   
                 cccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggac 
                   
               
               
                   
                 ccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagt 
                   
               
               
                   
                 tcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagaga 
                   
               
               
                   
                 ggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccag 
                   
               
               
                   
                 gactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctg 
                   
               
               
                   
                 cccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccag 
                   
               
               
                   
                 gtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctga 
                   
               
               
                   
                 gctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaac 
                   
               
               
                   
                 ggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggc 
                   
               
               
                   
                 tcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaac 
                   
               
               
                   
                 gtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtc 
                   
               
               
                   
                 cctgagcctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 Tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac 
                 SEQ ID NO: 
               
               
                   
                 agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 
                 62 
               
               
                   
                 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca 
                   
               
               
                   
                 agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac 
                   
               
               
                   
                 accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct 
                   
               
               
                   
                 actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaa 
                   
               
               
                   
                 gcgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcag 
                   
               
               
                   
                 ctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccg 
                   
               
               
                   
                 cgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaac 
                   
               
               
                   
                 agccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcct 
                   
               
               
                   
                 gagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgt 
                   
               
               
                   
                 acgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagct 
                   
               
               
                   
                 tcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 63 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctgg 
                   
               
               
                   
                 cgaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa 
                   
               
               
                   
                 acccatacccaggtgcagttggtggagtctgggggaggcgtggtccagcctggga 
                   
               
               
                   
                 cgtccctgagactctcctgtgcagcctctcaattcaggtttgatggttatggcatgcact 
                   
               
               
                   
                 gggtccgccaggccccaggcaaggggctggagtgggtggcatctatatcacatga 
                   
               
               
                   
                 tggaattaaaaagtatcacgcagaaaaagtgtggggccgcttcaccatctccagaga 
                   
               
               
                   
                 caattccaagaacacactgtatctacaaatgaacagcctgcgacctgaggacacgg 
                   
               
               
                   
                 ctctctactactgtgcgaaagatttgcgagaagacgaatgtgaagagtggtggtcgg 
                   
               
               
                   
                 attattacgattttgggaaacaactcccttgcgcaaagtcacgcggcggcttggttgg 
                   
               
               
                   
                 aattgctgataactggggccaagggacaatggtcaccgtctcttcagataagaccca 
                   
               
               
                   
                 caccgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagca 
                   
               
               
                   
                 cctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaacc 
                   
               
               
                   
                 ggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccg 
                   
               
               
                   
                 gctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctcca 
                   
               
               
                   
                 gcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacacc 
                   
               
               
                   
                 aaggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccacc 
                   
               
               
                   
                 gtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacc 
                   
               
               
                   
                 caaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacg 
                   
               
               
                   
                 tgagccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtg 
                   
               
               
                   
                 cataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtg 
                   
               
               
                   
                 gtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtg 
                   
               
               
                   
                 caaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagcca 
                   
               
               
                   
                 aagggcagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagct 
                   
               
               
                   
                 gaccaagaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacat 
                   
               
               
                   
                 cgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgc 
                   
               
               
                   
                 ctcccgtgctggactccgacggctccttcttcctctactcaaaactcaccgtggacaa 
                   
               
               
                   
                 gagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgc 
                   
               
               
                   
                 acaaccactacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 Cagtctgtgctgacgcagccgccctcagtgtctgcggccccaggacagaa 
                 SEQ ID NO: 
               
               
                   
                 ggtcaccatctcctgctctggaaacacctccaacattggcaataattttgtgtcc 
                 64 
               
               
                   
                 tggtatcaacagcgccccggcagagccccccaactcctcatttatgaaactg 
                   
               
               
                   
                 acaagcgaccctcagggattcctgaccgattctctgcttccaagtctggtacgt 
                   
               
               
                   
                 caggcaccctggccatcaccgggctgcagactggggacgaggccgattatt 
                   
               
               
                   
                 actgcgccacatgggctgccagcctgagttccgcgcgtgtcttcggaactgg 
                   
               
               
                   
                 gaccaaggtcatcgtcctggacaaaacccataccgcatccgaactgactcag 
                   
               
               
                   
                 gaccctgccgtctctgtggcactgaagcagactgtgactattacttgccgagg 
                   
               
               
                   
                 cgactcactgcggagccactacgcttcctggtatcagaagaaacccggcca 
                   
               
               
                   
                 ggcacctgtgctgctgttctacggaaagaacaataggccatctggcatcccc 
                   
               
               
                   
                 gaccgcttttctggcagtgcatcagggaaccgagccagtctgaccattaccg 
                   
               
               
                   
                 gcgcccaggctgaggacgaagccgattactattgcagctcccgggataaga 
                   
               
               
                   
                 gcggctccagactgagcgtgttcggaggaggaactaaactgaccgtcctcg 
                   
               
               
                   
                 ataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccacct 
                   
               
               
                   
                 agcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaac 
                   
               
               
                   
                 aacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg 
                   
               
               
                   
                 cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggac 
                   
               
               
                   
                 tccacctacagcctgagcagcaccctgacactgagcaaggccgactacgag 
                   
               
               
                   
                 aagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagcccc 
                   
               
               
                   
                 gtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 9 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlk 
                 SEQ ID NO: 
               
               
                   
                 prggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdf 
                 65 
               
               
                   
                 ehwgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns 
                   
               
               
                   
                 galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep 
                   
               
               
                   
                 kscdkthtcppcpapellggpsvflfppkpkddmisrtpevtcvvvdvshedpe 
                   
               
               
                   
                 vkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsn 
                   
               
               
                   
                 kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew 
                   
               
               
                   
                 esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhnh 
                   
               
               
                   
                 ytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 Eivltqspgtlslspgetaiiscrtsqygslawyqqrpgqaprlviysgstraagipdr 
                 SEQ ID NO: 
               
               
                   
                 fsgsrwgpdynitisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifp 
                 66 
               
               
                   
                 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv 
                 SEQ ID NO: 
               
               
                   
                 gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 
                 67 
               
               
                   
                 tgkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqvqlvesgggvv 
                   
               
               
                   
                 qpgtslrlscaasqfrfdgygmhwvrqapgkglewvasishdgikkyha 
                   
               
               
                   
                 ekvvvgrftisrdnskntlylqmnslrpedtalyycakdlredeceewwsd 
                   
               
               
                   
                 yydfgkqlpcaksrgglvgiadnwgqgtmvtvssdkthtastkgpsvfpl 
                   
               
               
                   
                 apsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly 
                   
               
               
                   
                 slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpa 
                   
               
               
                   
                 pellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd 
                   
               
               
                   
                 gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalp 
                   
               
               
                   
                 apiektiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmh 
                   
               
               
                   
                 ealhnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 qsvltqppsysaapgqkvtiscsgntsnignnfvswyqqrpgrapqlliyetdkrp 
                 SEQ ID NO: 
               
               
                   
                 sgipdrfsasksgtsgtlaitglqtgdeadyycatwaaslssarvfgtgtkvivldkth 
                 68 
               
               
                   
                 taseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrps 
                   
               
               
                   
                 gipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldktht 
                   
               
               
                   
                 rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqes 
                   
               
               
                   
                 vteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 9 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgc 
                 SEQ ID NO: 
               
               
                   
                 ggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatc 
                 69 
               
               
                   
                 agactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcg 
                   
               
               
                   
                 gagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgt 
                   
               
               
                   
                 gtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgt 
                   
               
               
                   
                 gtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcactggg 
                   
               
               
                   
                 gcagaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcgtgttc 
                   
               
               
                   
                 cctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctgcct 
                   
               
               
                   
                 cgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctgac 
                   
               
               
                   
                 cagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctgag 
                   
               
               
                   
                 cagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaacgt 
                   
               
               
                   
                 gaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagagctg 
                   
               
               
                   
                 cgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcccttc 
                   
               
               
                   
                 cgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccg 
                   
               
               
                   
                 aagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttcaatt 
                   
               
               
                   
                 ggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagaggaac 
                   
               
               
                   
                 agtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactgg 
                   
               
               
                   
                 ctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccccat 
                   
               
               
                   
                 cgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtgcac 
                   
               
               
                   
                 actgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgtgcc 
                   
               
               
                   
                 gtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggccagcc 
                   
               
               
                   
                 cgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct 
                   
               
               
                   
                 ggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgagcctg 
                   
               
               
                   
                 agccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag 
                 SEQ ID NO: 
               
               
                   
                 ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag 
                 70 
               
               
                   
                 gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg 
                   
               
               
                   
                 aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatcag 
                   
               
               
                   
                 caacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcgg 
                   
               
               
                   
                 ccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtg 
                   
               
               
                   
                 ttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcc 
                   
               
               
                   
                 tgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc 
                   
               
               
                   
                 ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactc 
                   
               
               
                   
                 cacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac 
                   
               
               
                   
                 aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga 
                   
               
               
                   
                 gcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 71 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctgg 
                   
               
               
                   
                 cgaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa 
                   
               
               
                   
                 acccatacccaggtgcagttggtggagtctgggggaggcgtggtccagcctggga 
                   
               
               
                   
                 cgtccctgagactctcctgtgcagcctctcaattcaggtttgatggttatggcatgcact 
                   
               
               
                   
                 gggtccgccaggccccaggcaaggggctggagtgggtggcatctatatcacatgat 
                   
               
               
                   
                 ggaattaaaaagtatcacgcagaaaaagtgtggggccgcttcaccatctccagagac 
                   
               
               
                   
                 aattccaagaacacactgtatctacaaatgaacagcctgcgacctgaggacacggct 
                   
               
               
                   
                 ctctactactgtgcgaaagatttgcgagaagacgaatgtgaagagtggtggtcggatt 
                   
               
               
                   
                 attacgattttgggaaacaactcccttgcgcaaagtcacgcggcggcttggttggaatt 
                   
               
               
                   
                 gctgataactggggccaagggacaatggtcaccgtctcttcagataagacccacacc 
                   
               
               
                   
                 gcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctct 
                   
               
               
                   
                 gggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtga 
                   
               
               
                   
                 cggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtc 
                   
               
               
                   
                 ctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagc 
                   
               
               
                   
                 ttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggt 
                   
               
               
                   
                 ggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgccc 
                   
               
               
                   
                 agcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaagga 
                   
               
               
                   
                 caccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagcca 
                   
               
               
                   
                 cgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataatgc 
                   
               
               
                   
                 caagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtc 
                   
               
               
                   
                 ctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctc 
                   
               
               
                   
                 caacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcag 
                   
               
               
                   
                 ccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgaccaaga 
                   
               
               
                   
                 atcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgtgg 
                   
               
               
                   
                 agtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgct 
                   
               
               
                   
                 ggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcaggtg 
                   
               
               
                   
                 gcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccacta 
                   
               
               
                   
                 cacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 cagtctgtgctgacgcagccgccctcagtgtctgcggccccaggacagaaggtcac 
                 SEQ ID NO: 
               
               
                   
                 catctcctgctctggaaacacctccaacattggcaataattttgtgtcctggtatcaaca 
                 72 
               
               
                   
                 gcgccccggcagagccccccaactcctcatttatgaaactgacaagcgaccctcag 
                   
               
               
                   
                 ggattcctgaccgattctctgcttccaagtctggtacgtcaggcaccctggccatcacc 
                   
               
               
                   
                 gggctgcagactggggacgaggccgattattactgcgccacatgggctgccagcct 
                   
               
               
                   
                 gagttccgcgcgtgtcttcggaactgggaccaaggtcatcgtcctg 
                   
               
               
                   
                 gacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggcactg 
                   
               
               
                   
                 aagcagactgtgactattacttgccgaggcgactcactgcggagccactacgcttcct 
                   
               
               
                   
                 ggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaat 
                   
               
               
                   
                 aggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagccagt 
                   
               
               
                   
                 ctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctcccg 
                   
               
               
                   
                 ggataagagcggctccagactgagcgtgttcggaggaggaactaaactgaccgtcc 
                   
               
               
                   
                 tcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctag 
                   
               
               
                   
                 cgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttcta 
                   
               
               
                   
                 cccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaa 
                   
               
               
                   
                 cagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgag 
                   
               
               
                   
                 cagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgc 
                   
               
               
                   
                 gaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcg 
                   
               
               
                   
                 agtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 10 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsggqmkkpgesmriscrasgyefidctnwirlapgkrpewmgwlk 
                 SEQ ID NO: 
               
               
                   
                 prggavnyarplqgrvtmadvysdtaflelrsltvddtavyfctrgkncdynwdf 
                 73 
               
               
                   
                 ehwgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns 
                   
               
               
                   
                 galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep 
                   
               
               
                   
                 kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe 
                   
               
               
                   
                 vkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsn 
                   
               
               
                   
                 kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew 
                   
               
               
                   
                 esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhnh 
                   
               
               
                   
                 ytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 Eivltqspgtlslspgetaiiscrtsqygslawyqqrpgqaprlviysgstraagipdr 
                 SEQ ID NO: 
               
               
                   
                 fsgsrwgpdynltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifp 
                 74 
               
               
                   
                 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 qvqlvesgggvvqpgtslrlscaasqfrfdgygmhwvrqapgkglewv 
                 SEQ ID NO: 
               
               
                   
                 asishdgikkyhaekvvvgrftisrdnskntlylqmnslrpedtalyycakd 
                 75 
               
               
                   
                 lredeceewwsdyydfgkqlpcaksrgglvgiadnwgqgtmvtvssdk 
                   
               
               
                   
                 thtevrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkgle 
                   
               
               
                   
                 wvgritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyf 
                   
               
               
                   
                 cartgkyydfwwgyppgeeyfqdwgqgtlvivssdkthtastkgpsvfp 
                   
               
               
                   
                 lapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl 
                   
               
               
                   
                 yslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcp 
                   
               
               
                   
                 apellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd 
                   
               
               
                   
                 gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalp 
                   
               
               
                   
                 apiektiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmh 
                   
               
               
                   
                 ealhnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsg 
                 SEQ ID NO: 
               
               
                   
                 ipdrfsgsasgnrasititgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtq 
                 76 
               
               
                   
                 svltqppsysaapgqkvtiscsgntsnignnfvswyqqrpgrapqlliyetdkrps 
                   
               
               
                   
                 gipdrfsasksgtsgtlaitglqtgdeadyycatwaaslssarvfgtgtkvivldktht 
                   
               
               
                   
                 rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqes 
                   
               
               
                   
                 vteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 10 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatg 
                 SEQ ID NO: 
               
               
                   
                 cggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggat 
                 77 
               
               
                   
                 cagactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggc 
                   
               
               
                   
                 ggagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggac 
                   
               
               
                   
                 gtgtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgc 
                   
               
               
                   
                 cgtgtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcact 
                   
               
               
                   
                 ggggcagaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcg 
                   
               
               
                   
                 tgttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggc 
                   
               
               
                   
                 tgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccc 
                   
               
               
                   
                 tgaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagc 
                   
               
               
                   
                 ctgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctg 
                   
               
               
                   
                 caacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaa 
                   
               
               
                   
                 gagctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggag 
                   
               
               
                   
                 gcccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccgga 
                   
               
               
                   
                 cccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaag 
                   
               
               
                   
                 ttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagag 
                   
               
               
                   
                 aggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccag 
                   
               
               
                   
                 gactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctg 
                   
               
               
                   
                 cccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccag 
                   
               
               
                   
                 gtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctga 
                   
               
               
                   
                 gctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaac 
                   
               
               
                   
                 ggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggc 
                   
               
               
                   
                 tcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaac 
                   
               
               
                   
                 gtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtc 
                   
               
               
                   
                 cctgagcctgagccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag 
                 SEQ ID NO: 78 
               
               
                   
                 ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag 
                   
               
               
                   
                 gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg 
                   
               
               
                   
                 aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatca 
                   
               
               
                   
                 gcaacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcg 
                   
               
               
                   
                 gccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcg 
                   
               
               
                   
                 tgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtg 
                   
               
               
                   
                 cctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaac 
                   
               
               
                   
                 gccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaagga 
                   
               
               
                   
                 ctccacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaag 
                   
               
               
                   
                 cacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgacca 
                   
               
               
                   
                 agagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagttggtggagtctgggggaggcgtggtccagcctgggacgtccctga 
                 SEQ ID NO: 
               
               
                   
                 gactctcctgtgcagcctctcaattcaggtttgatggttatggcatgcactgggtccgc 
                 79 
               
               
                   
                 caggccccaggcaaggggctggagtgggtggcatctatatcacatgatggaattaa 
                   
               
               
                   
                 aaagtatcacgcagaaaaagtgtggggccgcttcaccatctccagagacaattccaa 
                   
               
               
                   
                 gaacacactgtatctacaaatgaacagcctgcgacctgaggacacggctctctacta 
                   
               
               
                   
                 ctgtgcgaaagatttgcgagaagacgaatgtgaagagtggtggtcggattattacga 
                   
               
               
                   
                 ttttgggaaacaactcccttgcgcaaagtcacgcggcggcttggttggaattgctgat 
                   
               
               
                   
                 aactggggccaagggacaatggtcaccgtctcttcagacaaaacccataccgaggt 
                   
               
               
                   
                 tagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgcctga 
                   
               
               
                   
                 gctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggcagcct 
                   
               
               
                   
                 ccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagggctgg 
                   
               
               
                   
                 tccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaatacc 
                   
               
               
                   
                 aagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggatattact 
                   
               
               
                   
                 tctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggcgagg 
                   
               
               
                   
                 aatattttcaagactggggtcagggaacccttgttatcgtgtcctccgataagacccac 
                   
               
               
                   
                 accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcac 
                   
               
               
                   
                 ctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccg 
                   
               
               
                   
                 gtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccgg 
                   
               
               
                   
                 ctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccag 
                   
               
               
                   
                 cagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacacca 
                   
               
               
                   
                 aggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgt 
                   
               
               
                   
                 gcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaaccca 
                   
               
               
                   
                 aggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtg 
                   
               
               
                   
                 agccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgca 
                   
               
               
                   
                 taatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtc 
                   
               
               
                   
                 agcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaa 
                   
               
               
                   
                 ggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaag 
                   
               
               
                   
                 ggcagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgac 
                   
               
               
                   
                 caagaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgc 
                   
               
               
                   
                 cgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcc 
                   
               
               
                   
                 cgtgctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagc 
                   
               
               
                   
                 aggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaac 
                   
               
               
                   
                 cactacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactg 
                 SEQ ID NO: 
               
               
                   
                 tgactattacttgccgaggcgactcactgcggagccactacgcttcctggtat 
                 80 
               
               
                   
                 cagaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaat 
                   
               
               
                   
                 aggccatctggcatccccgaccgctggtctggcagtgcatcagggaaccgag 
                   
               
               
                   
                 ccagtctgaccattaccggcgcccaggctgaggacgaagccgattactattg 
                   
               
               
                   
                 cagctcccgggataagagcggctccagactgagcgtgttcggaggaggaa 
                   
               
               
                   
                 ctaaactgaccgtcctcgacaaaacccatacc 
                   
               
               
                   
                 cagtctgtgctgacgcagccgccctcagtgtctgcggccccaggacagaag 
                   
               
               
                   
                 gtcaccatctcctgctctggaaacacctccaacattggcaataattttgtgtcct 
                   
               
               
                   
                 ggtatcaacagcgccccggcagagccccccaactcctcatttatgaaactga 
                   
               
               
                   
                 caagcgaccctcagggattcctgaccgattctctgcttccaagtctggtacgtc 
                   
               
               
                   
                 aggcaccctggccatcaccgggctgcagactggggacgaggccgattatta 
                   
               
               
                   
                 ctgcgccacatgggctgccagcctgagttccgcgcgtgtcttcggaactggg 
                   
               
               
                   
                 accaaggtcatcgtcctg 
                   
               
               
                   
                 gataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccacc 
                   
               
               
                   
                 tagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaac 
                   
               
               
                   
                 aacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg 
                   
               
               
                   
                 cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggac 
                   
               
               
                   
                 tccacctacagcctgagcagcaccctgacactgagcaaggccgactacgag 
                   
               
               
                   
                 aagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagcccc 
                   
               
               
                   
                 gtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 11 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq 
                 SEQ ID NO: 
               
               
                   
                 ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 
                 81 
               
               
                   
                 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn 
                   
               
               
                   
                 sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve 
                   
               
               
                   
                 pkscdkthtcppcpapellggpsvflfppkpkddmisrtpevtcvvvdvshedp 
                   
               
               
                   
                 evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs 
                   
               
               
                   
                 nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhn 
                   
               
               
                   
                 hytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                 SEQ ID NO: 
               
               
                   
                 gvpsrfsgsgfhtsfnitisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 
                 82 
               
               
                   
                 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl 
                   
               
               
                   
                 sstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvg 
                 SEQ ID NO: 
               
               
                   
                 ritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcart 
                 83 
               
               
                   
                 gkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevrk 
                   
               
               
                   
                 pgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkviv 
                   
               
               
                   
                 erfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalyddd 
                   
               
               
                   
                 galnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskst 
                   
               
               
                   
                 sggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvt 
                   
               
               
                   
                 vpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellgg 
                   
               
               
                   
                 psvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhn 
                   
               
               
                   
                 aktkpreeqynstyrvvsyltvlhqdwlngkeykckvsnkalpapiektis 
                   
               
               
                   
                 kakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngq 
                   
               
               
                   
                 pennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhy 
                   
               
               
                   
                 tqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass 
                 SEQ ID NO: 
               
               
                   
                 rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikd 
                 84 
               
               
                   
                 kthtaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnr 
                   
               
               
                   
                 psgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldk 
                   
               
               
                   
                 thtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq 
                   
               
               
                   
                 esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 11 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 85 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg 
                   
               
               
                   
                 ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg 
                   
               
               
                   
                 cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg 
                   
               
               
                   
                 accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag 
                   
               
               
                   
                 ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc 
                   
               
               
                   
                 cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc 
                   
               
               
                   
                 ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca 
                   
               
               
                   
                 attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg 
                   
               
               
                   
                 aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac 
                   
               
               
                   
                 tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc 
                   
               
               
                   
                 catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg 
                   
               
               
                   
                 cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt 
                   
               
               
                   
                 gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct 
                   
               
               
                   
                 tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgag 
                   
               
               
                   
                 cctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac 
                 SEQ ID NO: 
               
               
                   
                 agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 
                 86 
               
               
                   
                 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca 
                   
               
               
                   
                 agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac 
                   
               
               
                   
                 accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct 
                   
               
               
                   
                 actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaag 
                   
               
               
                   
                 cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc 
                   
               
               
                   
                 tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgc 
                   
               
               
                   
                 gaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca 
                   
               
               
                   
                 gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg 
                   
               
               
                   
                 agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgta 
                   
               
               
                   
                 cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt 
                   
               
               
                   
                 caaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 87 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctgg 
                   
               
               
                   
                 cgaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa 
                   
               
               
                   
                 acccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggc 
                   
               
               
                   
                 acctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctg 
                   
               
               
                   
                 cactgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcc 
                   
               
               
                   
                 acgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcga 
                   
               
               
                   
                 ctgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggc 
                   
               
               
                   
                 gataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacg 
                   
               
               
                   
                 ccctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagc 
                   
               
               
                   
                 aacctggaattctggggccagggcacagccgtgaccgtgtcatctgataagaccca 
                   
               
               
                   
                 caccgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcac 
                   
               
               
                   
                 ctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccgg 
                   
               
               
                   
                 tgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggct 
                   
               
               
                   
                 gtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagc 
                   
               
               
                   
                 agcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaa 
                   
               
               
                   
                 ggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtg 
                   
               
               
                   
                 cccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaa 
                   
               
               
                   
                 ggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtga 
                   
               
               
                   
                 gccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcata 
                   
               
               
                   
                 atgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcag 
                   
               
               
                   
                 cgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaagg 
                   
               
               
                   
                 tctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg 
                   
               
               
                   
                 cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca 
                   
               
               
                   
                 agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt 
                   
               
               
                   
                 ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt 
                   
               
               
                   
                 gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag 
                   
               
               
                   
                 gtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaacca 
                   
               
               
                   
                 ctacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgag 
                 SEQ ID NO: 
               
               
                   
                 agcgccagcatcagctgcaagagcagccactccctgatccacggcgaccg 
                 88 
               
               
                   
                 gaacaactacctggcttggtacgtgcagaagcccggcagatccccccagct 
                   
               
               
                   
                 gctgatctacctggccagcagcagagccagcggcgtgcccgatagattttct 
                   
               
               
                   
                 ggcagcggcagcgacaaggacttcaccctgaagatcagccgggtggaaac 
                   
               
               
                   
                 cgaggacgtgggcacctactactgtatgcagggcagagagagcccctgga 
                   
               
               
                   
                 cctttggccagggcaccaaggtggacatcaaggacaaaacccataccgcat 
                   
               
               
                   
                 ccgaactgactcaggaccctgccgtctctgtggcactgaagcagactgtgac 
                   
               
               
                   
                 tattacttgccgaggcgactcactgcggagccactacgcttcctggtatcaga 
                   
               
               
                   
                 agaaacccggccaggcacctgtgctgctgttctacggaaagaacaataggc 
                   
               
               
                   
                 catctggcatccccgaccgcttttctggcagtgcatcagggaaccgagccag 
                   
               
               
                   
                 tctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagc 
                   
               
               
                   
                 tcccgggataagagcggctccagactgagcgtgttcggaggaggaactaaa 
                   
               
               
                   
                 ctgaccgtcctcgataagacccatacccgtacggtggccgctcccagcgtgt 
                   
               
               
                   
                 tcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgt 
                   
               
               
                   
                 gtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggt 
                   
               
               
                   
                 ggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcag 
                   
               
               
                   
                 gacagcaaggactccacctacagcctgagcagcaccctgacactgagcaa 
                   
               
               
                   
                 ggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagg 
                   
               
               
                   
                 gcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 12 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq 
                 SEQ ID NO: 
               
               
                   
                 ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 
                 89 
               
               
                   
                 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn 
                   
               
               
                   
                 sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve 
                   
               
               
                   
                 pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp 
                   
               
               
                   
                 evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs 
                   
               
               
                   
                 nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhn 
                   
               
               
                   
                 hytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                 SEQ ID NO: 90 
               
               
                   
                 gvpsrfsgsgfhtsfnitisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 
                   
               
               
                   
                 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl 
                   
               
               
                   
                 sstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvg 
                 SEQ ID NO: 
               
               
                   
                 ritgpgegwsvdyaesykgrftisrdntkntlylemnnvrtedtgyyfcart 
                 91 
               
               
                   
                 gkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqmqlqesgpgly 
                   
               
               
                   
                 kpsetlsltcsysgasisdsywswirrspgkglewigyvhksgdtnyspsl 
                   
               
               
                   
                 ksrvnlsldtsknqvslslvaataadsgkyycartlhgrriygivafnewfty 
                   
               
               
                   
                 fymdvwgngtqvtvssdkthtastkgpsvfplapsskstsggtaalgclvk 
                   
               
               
                   
                 dyfpepvtvswnsgaltsgyhtfpaylqssglyslssvvtvpssslgtqtyic 
                   
               
               
                   
                 nynhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkd 
                   
               
               
                   
                 tlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqyns 
                   
               
               
                   
                 tyrvvsvlvylhqdwlngkeykckvsnkalpapiektiskakgqprepqv 
                   
               
               
                   
                 ytlppcrdeltknqvslwclykgfypsdiavewesngqpennykttppvl 
                   
               
               
                   
                 dsdgsfflyskltvdksrwqqgnyfscsvmhealhnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 sdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsgs 
                 SEQ ID NO: 
               
               
                   
                 pdspfgttatltitsveagdeadyychiwdsrvptkwvfgggaltvldkthtaselt 
                 92 
               
               
                   
                 qdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgipdrf 
                   
               
               
                   
                 sgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtvaap 
                   
               
               
                   
                 svfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds 
                   
               
               
                   
                 kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 12 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 93 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg 
                   
               
               
                   
                 ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg 
                   
               
               
                   
                 cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg 
                   
               
               
                   
                 accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag 
                   
               
               
                   
                 ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc 
                   
               
               
                   
                 cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc 
                   
               
               
                   
                 ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca 
                   
               
               
                   
                 attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg 
                   
               
               
                   
                 aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac 
                   
               
               
                   
                 tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc 
                   
               
               
                   
                 catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg 
                   
               
               
                   
                 cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt 
                   
               
               
                   
                 gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct 
                   
               
               
                   
                 tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgag 
                   
               
               
                   
                 cctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac 
                 SEQ ID NO: 
               
               
                   
                 agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 
                 94 
               
               
                   
                 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca 
                   
               
               
                   
                 agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac 
                   
               
               
                   
                 accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct 
                   
               
               
                   
                 actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaag 
                   
               
               
                   
                 cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc 
                   
               
               
                   
                 tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgc 
                   
               
               
                   
                 gaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca 
                   
               
               
                   
                 gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg 
                   
               
               
                   
                 agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgta 
                   
               
               
                   
                 cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt 
                   
               
               
                   
                 caaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 95 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctgg 
                   
               
               
                   
                 cgaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa 
                   
               
               
                   
                 acccatacccagatgcagctgcaggagagcggccctggactcgtgaagcccagcg 
                   
               
               
                   
                 agaccctgagcctgacatgcagcgtgagcggcgccagcatcagcgacagctactg 
                   
               
               
                   
                 gagctggatcaggaggagccctggcaagggcctggagtggatcggctacgtgcac 
                   
               
               
                   
                 aagagcggcgacaccaactacagcccctccctgaagtccagggtgaacctgtccct 
                   
               
               
                   
                 ggacaccagcaagaaccaggtgagcctgtccctggtggctgccacagctgctgac 
                   
               
               
                   
                 agcggcaagtactactgtgccaggaccctgcacggcaggaggatctacggcatcgt 
                   
               
               
                   
                 ggccttcaacgagtggttcacctacttctacatggacgtgtggggcaacggcaccca 
                   
               
               
                   
                 ggtgaccgtgagctccgataagacccacaccgcttccaccaagggcccatcggtctt 
                   
               
               
                   
                 ccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgc 
                   
               
               
                   
                 ctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccct 
                   
               
               
                   
                 gaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctc 
                   
               
               
                   
                 agcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatctt 
                   
               
               
                   
                 gtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggacc 
                   
               
               
                   
                 gtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccct 
                   
               
               
                   
                 gaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaa 
                   
               
               
                   
                 ctggtatgttgacggcgtggaggtgcataatgccaagacaaagccgcgggaggag 
                   
               
               
                   
                 cagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactg 
                   
               
               
                   
                 gctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagccccca 
                   
               
               
                   
                 tcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacac 
                   
               
               
                   
                 cctgcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctggt 
                   
               
               
                   
                 aaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccg 
                   
               
               
                   
                 gagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctct 
                   
               
               
                   
                 actcaaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgc 
                   
               
               
                   
                 tccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctc 
                   
               
               
                   
                 cgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 tccgacatcagcgtggcccccggagagacagccaggatctcctgcggcga 
                 SEQ ID NO: 
               
               
                   
                 gaagagcctgggaagcagggctgtgcagtggtaccaacacagggccgga 
                 96 
               
               
                   
                 caggctcccagcctgatcatctacaacaaccaggacaggcccagcggcatc 
                   
               
               
                   
                 cctgagaggttcagcggaagccccgacagccccttcggaaccacagccac 
                   
               
               
                   
                 cctgaccatcacaagcgtggaagccggcgacgaggccgactactactgcc 
                   
               
               
                   
                 acatctgggacagcagggtgcccaccaagtgggtgtttggcggcggcacca 
                   
               
               
                   
                 ccctgaccgtgctggacaaaacccataccgcatccgaactgactcaggacc 
                   
               
               
                   
                 ctgccgtctctgtggcactgaagcagactgtgactattacttgccgaggcgac 
                   
               
               
                   
                 tcactgcggagccactacgcttcctggtatcagaagaaacccggccaggca 
                   
               
               
                   
                 cctgtgctgctgttctacggaaagaacaataggccatctggcatccccgacc 
                   
               
               
                   
                 gcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggcgc 
                   
               
               
                   
                 ccaggctgaggacgaagccgattactattgcagctcccgggataagagcgg 
                   
               
               
                   
                 ctccagactgagcgtgttcggaggaggaactaaactgaccgtcctcgataag 
                   
               
               
                   
                 acccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcga 
                   
               
               
                   
                 cgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttct 
                   
               
               
                   
                 acccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagag 
                   
               
               
                   
                 cggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacc 
                   
               
               
                   
                 tacagcctgagcagcaccctgacactgagcaaggccgactacgagaagca 
                   
               
               
                   
                 caaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgac 
                   
               
               
                   
                 caagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 13 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwis 
                 SEQ ID NO: 
               
               
                   
                 hegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyal 
                 97 
               
               
                   
                 ydddgalnwavdvdylsnlefwgqgtavtvss astkgpsvfplapsskstsggta   
                   
               
               
                   
                 
                   algclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqt 
                 
                   
               
               
                   
                 
                   vicnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkdd 
                 
                   
               
               
                   
                 
                   misrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvs 
                 
                   
               
               
                   
                 
                   vltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvctlppsrdelt 
                 
                   
               
               
                   
                 
                   knqvslscavkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdk 
                 
                   
               
               
                   
                 
                   srwqqgnvfscsvmhealhnhytqkslslspg 
                 
                   
               
               
                   
               
               
                 Light chain A 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas 
                 SEQ ID NO: 
               
               
                   
                 srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikr 
                 98 
               
               
                   
                 tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesv 
                   
               
               
                   
                 teqdskdstyslsstftlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv 
                 SEQ ID NO: 
               
               
                   
                 gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfca 
                 99 
               
               
                   
                 rtgkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqmqlqesgpgl 
                   
               
               
                   
                 vkpsetlsltcsvsgasisdsywswirrspgkglewigyvhksgdtnysps 
                   
               
               
                   
                 lksrvnlsldtsknqvslslvaataadsgkyycartlhgrriygivafnewft 
                   
               
               
                   
                 yfymdvwgngtqvtvssdkthtastkgpsvfplapsskstsggtaalgclv 
                   
               
               
                   
                 kdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqty 
                   
               
               
                   
                 icnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkp 
                   
               
               
                   
                 kdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeq 
                   
               
               
                   
                 ynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqpre 
                   
               
               
                   
                 pqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpennyktt 
                   
               
               
                   
                 ppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslsls 
                   
               
               
                   
                 pg 
                   
               
               
                   
               
               
                 Light chain B 
                 sdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsg 
                 SEQ ID NO: 
               
               
                   
                 spdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtasel 
                 100 
               
               
                   
                 tqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgipdr 
                   
               
               
                   
                 fsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtvaa 
                   
               
               
                   
                 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd 
                   
               
               
                   
                 skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 13 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga 
                 SEQ ID NO: 
               
               
                   
                 aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 
                 101 
               
               
                   
                 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc 
                   
               
               
                   
                 gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca 
                   
               
               
                   
                 gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc 
                   
               
               
                   
                 cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac 
                   
               
               
                   
                 gacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaacctgg 
                   
               
               
                   
                 aattctggggccagggcacagccgtgaccgtgtcatctgcttcgaccaagggcccc 
                   
               
               
                   
                 agcgtgttccctctggcccctagcagcaagagcacatctggcggaacagccgccct 
                   
               
               
                   
                 gggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctgg 
                   
               
               
                   
                 cgccctgaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgt 
                   
               
               
                   
                 acagcctgagcagcgtcgtgacagtgcccagcagctctctgggcacccagaccta 
                   
               
               
                   
                 catctgcaacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtgga 
                   
               
               
                   
                 acccaagagctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgc 
                   
               
               
                   
                 tgggaggcccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatca 
                   
               
               
                   
                 gccggacccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctga 
                   
               
               
                   
                 agtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaag 
                   
               
               
                   
                 ccaagagaggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgct 
                   
               
               
                   
                 gcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggc 
                   
               
               
                   
                 cctgcctgcccccatcgagaaaaccatcagcaaggccaagggccagccccgcga 
                   
               
               
                   
                 accccaggtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggt 
                   
               
               
                   
                 gtccctgagctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatggga 
                   
               
               
                   
                 gagcaacggccagcccgagaacaactacaagaccaccccccctgtgctggacag 
                   
               
               
                   
                 cgacggctcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagca 
                   
               
               
                   
                 gggcaacgtgttcagctgctccgtgatgcacgaggccctgcacaaccactacaccc 
                   
               
               
                   
                 agaagtccctgagcctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg 
                 SEQ ID NO: 
               
               
                   
                 ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                 102 
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctgg 
                   
               
               
                   
                 ccagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaa 
                   
               
               
                   
                 ggacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactact 
                   
               
               
                   
                 gtatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacat 
                   
               
               
                   
                 caagcgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagct 
                   
               
               
                   
                 gaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggc 
                   
               
               
                   
                 caaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaa 
                   
               
               
                   
                 gcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctga 
                   
               
               
                   
                 cactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgaccca 
                   
               
               
                   
                 ccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 103 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctgg 
                   
               
               
                   
                 cgaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa 
                   
               
               
                   
                 acccatacccagatgcagctgcaggagagcggccctggactcgtgaagcccagc 
                   
               
               
                   
                 gagaccctgagcctgacatgcagcgtgagcggcgccagcatcagcgacagctact 
                   
               
               
                   
                 ggagctggatcaggaggagccctggcaagggcctggagtggatcggctacgtgc 
                   
               
               
                   
                 acaagagcggcgacaccaactacagcccctccctgaagtccagggtgaacctgtc 
                   
               
               
                   
                 cctggacaccagcaagaaccaggtgagcctgtccctggtggctgccacagctgctg 
                   
               
               
                   
                 acagcggcaagtactactgtgccaggaccctgcacggcaggaggatctacggcat 
                   
               
               
                   
                 cgtggccttcaacgagtggacacctacttctacatggacgtgtggggcaacggcac 
                   
               
               
                   
                 ccaggtgaccgtgagctccgataagacccacaccgcttccaccaagggcccatcg 
                   
               
               
                   
                 gtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctggg 
                   
               
               
                   
                 ctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcg 
                   
               
               
                   
                 ccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctact 
                   
               
               
                   
                 ccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatc 
                   
               
               
                   
                 tgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagccca 
                   
               
               
                   
                 aatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggg 
                   
               
               
                   
                 gaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccgga 
                   
               
               
                   
                 cccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaa 
                   
               
               
                   
                 gttcaactggtatgttgacggcgtggaggtgcataatgccaagacaaagccgcggg 
                   
               
               
                   
                 aggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccag 
                   
               
               
                   
                 gactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccag 
                   
               
               
                   
                 cccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacagg 
                   
               
               
                   
                 tgtacaccctgcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggt 
                   
               
               
                   
                 gcctggtaaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatggg 
                   
               
               
                   
                 cagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctcctt 
                   
               
               
                   
                 cttcctctactcaaaactcaccgtggacaagagcaggtggcagcaggggaacgtctt 
                   
               
               
                   
                 ctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctc 
                   
               
               
                   
                 cctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 tccgacatcagcgtggcccccggagagacagccaggatctcctgcggcga 
                 SEQ ID NO: 
               
               
                   
                 gaagagcctgggaagcagggctgtgcagtggtaccaacacagggccgga 
                 104 
               
               
                   
                 caggctcccagcctgatcatctacaacaaccaggacaggcccagcggcatc 
                   
               
               
                   
                 cctgagaggttcagcggaagccccgacagccccttcggaaccacagccac 
                   
               
               
                   
                 cctgaccatcacaagcgtggaagccggcgacgaggccgactactactgcc 
                   
               
               
                   
                 acatctgggacagcagggtgcccaccaagtgggtgtttggcggcggcacc 
                   
               
               
                   
                 accctgaccgtgctggacaaaacccataccgcatccgaactgactcaggac 
                   
               
               
                   
                 cctgccgtctctgtggcactgaagcagactgtgactattacttgccgaggcga 
                   
               
               
                   
                 ctcactgcggagccactacgcttcctggtatcagaagaaacccggccaggc 
                   
               
               
                   
                 acctgtgctgctgttctacggaaagaacaataggccatctggcatccccgac 
                   
               
               
                   
                 cgcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggcg 
                   
               
               
                   
                 cccaggctgaggacgaagccgattactattgcagctcccgggataagagcg 
                   
               
               
                   
                 gctccagactgagcgtgttcggaggaggaactaaactgaccgtcctcgataa 
                   
               
               
                   
                 gacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagc 
                   
               
               
                   
                 gacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact 
                   
               
               
                   
                 tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcag 
                   
               
               
                   
                 agcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactcca 
                   
               
               
                   
                 cctacagcctgagcagcaccctgacactgagcaaggccgactacgagaag 
                   
               
               
                   
                 cacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtg 
                   
               
               
                   
                 accaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 14 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq 
                 SEQ ID NO: 
               
               
                   
                 ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 
                 105 
               
               
                   
                 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn 
                   
               
               
                   
                 sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve 
                   
               
               
                   
                 pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp 
                   
               
               
                   
                 evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckv 
                   
               
               
                   
                 snkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiav 
                   
               
               
                   
                 ewesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmheal 
                   
               
               
                   
                 hnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkilihhtssved 
                 SEQ ID NO: 
               
               
                   
                 gvpsrfsgsgfhtsfnitisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifp 
                 106 
               
               
                   
                 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdsty 
                   
               
               
                   
                 slsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwm 
                 SEQ ID NO: 
               
               
                   
                 gwishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakg 
                 107 
               
               
                   
                 skhrlrdyalydddgalnwavdvdylsnlefwgqgtavtvssdkthtevrl 
                   
               
               
                   
                 vesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgritg 
                   
               
               
                   
                 pgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartgky 
                   
               
               
                   
                 ydfwwgyppgeeyfqdwgqgtlvivssdkthtastkgpsvfplapssks 
                   
               
               
                   
                 tsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv 
                   
               
               
                   
                 tvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellg 
                   
               
               
                   
                 gpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvev 
                   
               
               
                   
                 hnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiek 
                   
               
               
                   
                 tiskakgqprepqvytlppecdeltknqvslwclvkgfypsdiavewesn 
                   
               
               
                   
                 gqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealh 
                   
               
               
                   
                 nhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 aseltqdpayvvalkqtvtitcrgdskshyaswyqkkpgqapvllfygknnrpsg 
                 SEQ ID NO: 
               
               
                   
                 ipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldktht 
                 108 
               
               
                   
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas 
                   
               
               
                   
                 srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik 
                   
               
               
                   
                 dkthtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsg 
                   
               
               
                   
                 nsqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 14 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 109 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgt 
                   
               
               
                   
                 accgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgt 
                   
               
               
                   
                 gtactactgcgccagagacagaagctacggcgacagcagctgggctctggatgctt 
                   
               
               
                   
                 ggggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgt 
                   
               
               
                   
                 gttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggct 
                   
               
               
                   
                 gcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccct 
                   
               
               
                   
                 gaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcc 
                   
               
               
                   
                 tgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgc 
                   
               
               
                   
                 aacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaag 
                   
               
               
                   
                 agctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggagg 
                   
               
               
                   
                 cccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggac 
                   
               
               
                   
                 ccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagt 
                   
               
               
                   
                 tcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagaga 
                   
               
               
                   
                 ggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccag 
                   
               
               
                   
                 gactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctg 
                   
               
               
                   
                 cccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccag 
                   
               
               
                   
                 gtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctga 
                   
               
               
                   
                 gctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaac 
                   
               
               
                   
                 ggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggc 
                   
               
               
                   
                 tcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaac 
                   
               
               
                   
                 gtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtc 
                   
               
               
                   
                 cctgagcctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac 
                 SEQ ID NO: 
               
               
                   
                 agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 
                 110 
               
               
                   
                 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca 
                   
               
               
                   
                 agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac 
                   
               
               
                   
                 accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct 
                   
               
               
                   
                 actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaa 
                   
               
               
                   
                 gcgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcag 
                   
               
               
                   
                 ctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccg 
                   
               
               
                   
                 cgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaac 
                   
               
               
                   
                 agccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcct 
                   
               
               
                   
                 gagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgt 
                   
               
               
                   
                 acgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagct 
                   
               
               
                   
                 tcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga 
                 SEQ ID NO: 
               
               
                   
                 aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 
                 111 
               
               
                   
                 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc 
                   
               
               
                   
                 gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca 
                   
               
               
                   
                 gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc 
                   
               
               
                   
                 cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac 
                   
               
               
                   
                 gacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaacctgg 
                   
               
               
                   
                 aattctggggccagggcacagccgtgaccgtgtcatctgacaaaacccataccgag 
                   
               
               
                   
                 gttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgcct 
                   
               
               
                   
                 gagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggcag 
                   
               
               
                   
                 cctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagggc 
                   
               
               
                   
                 tggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaat 
                   
               
               
                   
                 accaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggatatt 
                   
               
               
                   
                 acttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctggcg 
                   
               
               
                   
                 aggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgataagac 
                   
               
               
                   
                 ccacaccgcttccaccaagggcccatcggtcttccccctggcaccctcctccaaga 
                   
               
               
                   
                 gcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccga 
                   
               
               
                   
                 accggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttc 
                   
               
               
                   
                 ccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccc 
                   
               
               
                   
                 tccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaa 
                   
               
               
                   
                 caccaaggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcc 
                   
               
               
                   
                 caccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaa 
                   
               
               
                   
                 aacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtg 
                   
               
               
                   
                 gacgtgagccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtgga 
                   
               
               
                   
                 ggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccg 
                   
               
               
                   
                 tgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtaca 
                   
               
               
                   
                 agtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaa 
                   
               
               
                   
                 gccaaagggcagccccgagaaccacaggtgtacaccctgcccccatgccgggat 
                   
               
               
                   
                 gagctgaccaagaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagc 
                   
               
               
                   
                 gacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagacc 
                   
               
               
                   
                 acgcctcccgtgctggactccgacggctccttcttcctctactcaaaactcaccgtgg 
                   
               
               
                   
                 acaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggct 
                   
               
               
                   
                 ctgcacaaccactacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactg 
                 SEQ ID NO: 
               
               
                   
                 tgactattacttgccgaggcgactcactgcggagccactacgcttcctggtat 
                 112 
               
               
                   
                 cagaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaat 
                   
               
               
                   
                 aggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgag 
                   
               
               
                   
                 ccagtctgaccattaccggcgcccaggctgaggacgaagccgattactattg 
                   
               
               
                   
                 cagctcccgggataagagcggctccagactgagcgtgttcggaggaggaa 
                   
               
               
                   
                 ctaaactgaccgtcctcgacaaaacccataccgacttcgtgctgacccagag 
                   
               
               
                   
                 ccctcacagcctgagcgtgacacctggcgagagcgccagcatcagctgca 
                   
               
               
                   
                 agagcagccactccctgatccacggcgaccggaacaactacctggcttggt 
                   
               
               
                   
                 acgtgcagaagcccggcagatccccccagctgctgatctacctggccagca 
                   
               
               
                   
                 gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcaccta 
                   
               
               
                   
                 ctactgtatgcagggcagagagagcccctggacctttggccagggcaccaa 
                   
               
               
                   
                 ggtggacatcaaggataagacccatacccgtacggtggccgctcccagcgt 
                   
               
               
                   
                 gttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtc 
                   
               
               
                   
                 gtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaag 
                   
               
               
                   
                 gtggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagc 
                   
               
               
                   
                 aggacagcaaggactccacctacagcctgagcagcaccctgacactgagc 
                   
               
               
                   
                 aaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccacca 
                   
               
               
                   
                 gggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 15 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwish 
                 SEQ ID NO: 
               
               
                   
                 egdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyaly 
                 113 
               
               
                   
                 dddgalnwavdvdylsnlefwgqgtavtvssastkgpsvfplapsskstsggtaal 
                   
               
               
                   
                 gclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslsswtvpssslgtqtyi 
                   
               
               
                   
                 cnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmi 
                   
               
               
                   
                 srtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreegynstyrvvsvlt 
                   
               
               
                   
                 vlhqdwlngkeykckvsnkalpapiektiskakgqprepqvctlppsrdeltknq 
                   
               
               
                   
                 vslscavkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrw 
                   
               
               
                   
                 qqgnvfscsvmhealhnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass 
                 SEQ ID NO: 
               
               
                   
                 rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrt 
                 114 
               
               
                   
                 vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt 
                   
               
               
                   
                 eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv 
                 SEQ ID NO: 
               
               
                   
                 gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 
                 115 
               
               
                   
                 tgkyydfwsgyppgeeyfqdwgqgtlvivssdkthtqmqlqesgpglv 
                   
               
               
                   
                 kpsetlsltcsvsgasisdsywswirrspgkglewigyvhksgdtnyspsl 
                   
               
               
                   
                 ksrvnlsldtsknqvslslvaataadsgkyycartlhgrriygivafnewfty 
                   
               
               
                   
                 fymdvwgngtqvtvssdkthtastkgpsvfplapsskstsggtaalgclvk 
                   
               
               
                   
                 dyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyic 
                   
               
               
                   
                 nvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkd 
                   
               
               
                   
                 tlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqyns 
                   
               
               
                   
                 tyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqv 
                   
               
               
                   
                 yftppcrdeltknqvslwclvkgfypsdiavewesngqpennykttppvl 
                   
               
               
                   
                 dsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 sdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsgs 
                 SEQ ID NO: 
               
               
                   
                 pdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtaselt 
                 116 
               
               
                   
                 qdpaysvalkqtytitcrgdslrshyaswyqkkpgqapvllfygknnrpsgipdrf 
                   
               
               
                   
                 sgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtvaap 
                   
               
               
                   
                 svfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds 
                   
               
               
                   
                 kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 15 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga 
                 SEQ ID NO: 
               
               
                   
                 aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 
                 117 
               
               
                   
                 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc 
                   
               
               
                   
                 gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca 
                   
               
               
                   
                 gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc 
                   
               
               
                   
                 cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac 
                   
               
               
                   
                 gacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaacctgg 
                   
               
               
                   
                 aattctggggccagggcacagccgtgaccgtgtcatctgcttcgaccaagggcccc 
                   
               
               
                   
                 agcgtgttccctctggcccctagcagcaagagcacatctggcggaacagccgccct 
                   
               
               
                   
                 gggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggc 
                   
               
               
                   
                 gccctgaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtac 
                   
               
               
                   
                 agcctgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacat 
                   
               
               
                   
                 ctgcaacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacc 
                   
               
               
                   
                 caagagctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgg 
                   
               
               
                   
                 gaggcccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagcc 
                   
               
               
                   
                 ggacccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtg 
                   
               
               
                   
                 aagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaa 
                   
               
               
                   
                 gagaggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcac 
                   
               
               
                   
                 caggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgc 
                   
               
               
                   
                 ctgcccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaacccc 
                   
               
               
                   
                 aggtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccct 
                   
               
               
                   
                 gagctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagca 
                   
               
               
                   
                 acggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacg 
                   
               
               
                   
                 gctcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggca 
                   
               
               
                   
                 acgtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagt 
                   
               
               
                   
                 ccctgagcctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg 
                 SEQ ID NO: 
               
               
                   
                 ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                 118 
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc 
                   
               
               
                   
                 cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg 
                   
               
               
                   
                 tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc 
                   
               
               
                   
                 aagcgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctg 
                   
               
               
                   
                 aagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcc 
                   
               
               
                   
                 aaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagc 
                   
               
               
                   
                 gtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgacac 
                   
               
               
                   
                 tgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccacca 
                   
               
               
                   
                 gggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 119 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc 
                   
               
               
                   
                 gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa 
                   
               
               
                   
                 cccatacccagatgcagctgcaggagagcggccctggactcgtgaagcccagcga 
                   
               
               
                   
                 gaccctgagcctgacatgcagcgtgagcggcgccagcatcagcgacagctactgg 
                   
               
               
                   
                 agctggatcaggaggagccctggcaagggcctggagtggatcggctacgtgcaca 
                   
               
               
                   
                 agagcggcgacaccaactacagcccctccctgaagtccagggtgaacctgtccctg 
                   
               
               
                   
                 gacaccagcaagaaccaggtgagcctgtccctggtggctgccacagctgctgaca 
                   
               
               
                   
                 gcggcaagtactactgtgccaggaccctgcacggcaggaggatctacggcatcgtg 
                   
               
               
                   
                 gccttcaacgagtggttcacctacttctacatggacgtgtggggcaacggcacccag 
                   
               
               
                   
                 gtgaccgtgagctccgataagacccacaccgcttccaccaagggcccatcggtcttc 
                   
               
               
                   
                 cccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcct 
                   
               
               
                   
                 ggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctga 
                   
               
               
                   
                 ccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcag 
                   
               
               
                   
                 cagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacg 
                   
               
               
                   
                 tgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgt 
                   
               
               
                   
                 gacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtc 
                   
               
               
                   
                 agtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgag 
                   
               
               
                   
                 gtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactg 
                   
               
               
                   
                 gtatgttgacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcag 
                   
               
               
                   
                 tacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctg 
                   
               
               
                   
                 aatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcga 
                   
               
               
                   
                 gaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctg 
                   
               
               
                   
                 cccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctggtaaa 
                   
               
               
                   
                 aggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggag 
                   
               
               
                   
                 aacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctact 
                   
               
               
                   
                 caaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctcc 
                   
               
               
                   
                 gtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccg 
                   
               
               
                   
                 ggt 
                   
               
               
                   
               
               
                 Light chain B 
                 tccgacatcagcgtggcccccggagagacagccaggatctcctgcggcga 
                 SEQ ID NO: 
               
               
                   
                 gaagagcctgggaagcagggctgtgcagtggtaccaacacagggccgga 
                 120 
               
               
                   
                 caggctcccagcctgatcatctacaacaaccaggacaggcccagcggcatc 
                   
               
               
                   
                 cctgagaggttcagcggaagccccgacagccccttcggaaccacagccac 
                   
               
               
                   
                 cctgaccatcacaagcgtggaagccggcgacgaggccgactactactgcc 
                   
               
               
                   
                 acatctgggacagcagggtgcccaccaagtgggtgtttggcggcggcacca 
                   
               
               
                   
                 ccctgaccgtgctggacaaaacccataccgcatccgaactgactcaggacc 
                   
               
               
                   
                 ctgccgtctctgtggcactgaagcagactgtgactattacttgccgaggcgac 
                   
               
               
                   
                 tcactgcggagccactacgcttcctggtatcagaagaaacccggccaggca 
                   
               
               
                   
                 cctgtgctgctgttctacggaaagaacaataggccatctggcatccccgacc 
                   
               
               
                   
                 gcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggcgc 
                   
               
               
                   
                 ccaggctgaggacgaagccgattactattgcagctcccgggataagagcgg 
                   
               
               
                   
                 ctccagactgagcgtgttcggaggaggaactaaactgaccgtcctcgataag 
                   
               
               
                   
                 acccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcga 
                   
               
               
                   
                 cgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttct 
                   
               
               
                   
                 acccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagag 
                   
               
               
                   
                 cggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacc 
                   
               
               
                   
                 tacagcctgagcagcaccctgacactgagcaaggccgactacgagaagca 
                   
               
               
                   
                 caaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgac 
                   
               
               
                   
                 caagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 16 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq 
                 SEQ ID NO: 
               
               
                   
                 ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 
                 121 
               
               
                   
                 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn 
                   
               
               
                   
                 sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve 
                   
               
               
                   
                 pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp 
                   
               
               
                   
                 evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs 
                   
               
               
                   
                 nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhn 
                   
               
               
                   
                 hytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                 SEQ ID NO: 
               
               
                   
                 gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsflhikrtvaapsvfifpp 
                 122 
               
               
                   
                 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl 
                   
               
               
                   
                 sstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv 
                 SEQ ID NO: 
               
               
                   
                 gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 
                 123 
               
               
                   
                 tgkyydfwsgyppgeeyfqdwgqgtlvivssdkthtqmqlqesgpglv 
                   
               
               
                   
                 kpsetlsltcsvsgasisdsywswirrspgkglewigyvhksgdtnyspsl 
                   
               
               
                   
                 ksrvnlsldtsknqvslslvaataadsgkyycartlhgrriygivafnewfty 
                   
               
               
                   
                 fymdvwgngtqvtvssdkthtastkgpsvfplapsskstsggtaalgclvk 
                   
               
               
                   
                 dyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyic 
                   
               
               
                   
                 nvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkd 
                   
               
               
                   
                 tlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqyns 
                   
               
               
                   
                 tyrvvsyltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqv 
                   
               
               
                   
                 ytlppcrdeltknqvslwclvkgfypsdiavewesngqpennykttppvl 
                   
               
               
                   
                 dsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 sdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsgs 
                 SEQ ID NO: 
               
               
                   
                 pdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtaselt 
                 124 
               
               
                   
                 qdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgipdrf 
                   
               
               
                   
                 sgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtvaap 
                   
               
               
                   
                 svfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds 
                   
               
               
                   
                 kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 16 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 125 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg 
                   
               
               
                   
                 ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg 
                   
               
               
                   
                 cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg 
                   
               
               
                   
                 accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag 
                   
               
               
                   
                 ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc 
                   
               
               
                   
                 cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc 
                   
               
               
                   
                 ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca 
                   
               
               
                   
                 attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg 
                   
               
               
                   
                 aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac 
                   
               
               
                   
                 tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc 
                   
               
               
                   
                 catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg 
                   
               
               
                   
                 cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt 
                   
               
               
                   
                 gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct 
                   
               
               
                   
                 tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgag 
                   
               
               
                   
                 cctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac 
                 SEQ ID NO: 
               
               
                   
                 agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 
                 126 
               
               
                   
                 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca 
                   
               
               
                   
                 agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac 
                   
               
               
                   
                 accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct 
                   
               
               
                   
                 actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaag 
                   
               
               
                   
                 cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc 
                   
               
               
                   
                 tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgc 
                   
               
               
                   
                 gaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca 
                   
               
               
                   
                 gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg 
                   
               
               
                   
                 agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgta 
                   
               
               
                   
                 cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt 
                   
               
               
                   
                 caaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 127 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc 
                   
               
               
                   
                 gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa 
                   
               
               
                   
                 cccatacccagatgcagctgcaggagagcggccctggactcgtgaagcccagcga 
                   
               
               
                   
                 gaccctgagcctgacatgcagcgtgagcggcgccagcatcagcgacagctactgg 
                   
               
               
                   
                 agctggatcaggaggagccctggcaagggcctggagtggatcggctacgtgcaca 
                   
               
               
                   
                 agagcggcgacaccaactacagcccctccctgaagtccagggtgaacctgtccctg 
                   
               
               
                   
                 gacaccagcaagaaccaggtgagcctgtccctggtggctgccacagctgctgaca 
                   
               
               
                   
                 gcggcaagtactactgtgccaggaccctgcacggcaggaggatctacggcatcgtg 
                   
               
               
                   
                 gccttcaacgagtggttcacctacttctacatggacgtgtggggcaacggcacccag 
                   
               
               
                   
                 gtgaccgtgagctccgataagacccacaccgcttccaccaagggcccatcggtcttc 
                   
               
               
                   
                 cccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcct 
                   
               
               
                   
                 ggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctga 
                   
               
               
                   
                 ccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcag 
                   
               
               
                   
                 cagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacg 
                   
               
               
                   
                 tgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgt 
                   
               
               
                   
                 gacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtc 
                   
               
               
                   
                 agtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgag 
                   
               
               
                   
                 gtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactg 
                   
               
               
                   
                 gtatgttgacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcag 
                   
               
               
                   
                 tacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctg 
                   
               
               
                   
                 aatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcga 
                   
               
               
                   
                 gaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctg 
                   
               
               
                   
                 cccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctggtaaa 
                   
               
               
                   
                 aggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggag 
                   
               
               
                   
                 aacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctact 
                   
               
               
                   
                 caaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctcc 
                   
               
               
                   
                 gtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccg 
                   
               
               
                   
                 ggt 
                   
               
               
                   
               
               
                 Light chain B 
                 tccgacatcagcgtggcccccggagagacagccaggatctcctgcggcga 
                 SEQ ID NO: 
               
               
                   
                 gaagagcctgggaagcagggctgtgcagtggtaccaacacagggccgga 
                 128 
               
               
                   
                 caggctcccagcctgatcatctacaacaaccaggacaggcccagcggcatc 
                   
               
               
                   
                 cctgagaggttcagcggaagccccgacagccccttcggaaccacagccac 
                   
               
               
                   
                 cctgaccatcacaagcgtggaagccggcgacgaggccgactactactgcc 
                   
               
               
                   
                 acatctgggacagcagggtgcccaccaagtgggtgtttggcggcggcacca 
                   
               
               
                   
                 ccctgaccgtgctggacaaaacccataccgcatccgaactgactcaggacc 
                   
               
               
                   
                 ctgccgtctctgtggcactgaagcagactgtgactattacttgccgaggcgac 
                   
               
               
                   
                 tcactgcggagccactacgcttcctggtatcagaagaaacccggccaggca 
                   
               
               
                   
                 cctgtgctgctgttctacggaaagaacaataggccatctggcatccccgacc 
                   
               
               
                   
                 gcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggcgc 
                   
               
               
                   
                 ccaggctgaggacgaagccgattactattgcagctcccgggataagagcgg 
                   
               
               
                   
                 ctccagactgagcgtgttcggaggaggaactaaactgaccgtcctcgataag 
                   
               
               
                   
                 acccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcga 
                   
               
               
                   
                 cgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttct 
                   
               
               
                   
                 acccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagag 
                   
               
               
                   
                 cggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacc 
                   
               
               
                   
                 tacagcctgagcagcaccctgacactgagcaaggccgactacgagaagca 
                   
               
               
                   
                 caaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgac 
                   
               
               
                   
                 caagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 17 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq 
                 SEQ ID NO: 
               
               
                   
                 ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 
                 129 
               
               
                   
                 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn 
                   
               
               
                   
                 sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve 
                   
               
               
                   
                 pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp 
                   
               
               
                   
                 evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs 
                   
               
               
                   
                 nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhn 
                   
               
               
                   
                 hytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                 SEQ ID NO: 
               
               
                   
                 gvpsrfsgsgfhtsfnitisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 
                 130 
               
               
                   
                 sdeqlksgtaswcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl 
                   
               
               
                   
                 sstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 qvhltqsgpevrkpgtsvkvsckapgntlktydlhwyrsvpgqglqwm 
                 SEQ ID NO: 
               
               
                   
                 gwishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakg 
                 131 
               
               
                   
                 skhrlrdyalydddgalnwavdvdylsnlefwgqgtavtvssdkthtqm 
                   
               
               
                   
                 qlqesgpglvkpsetlsltcsvsgasisdsywswirrspgkglewigyvhk 
                   
               
               
                   
                 sgdtnyspslksrvnlsldtsknqvslslvaataadsgkyycartlhgrriygi 
                   
               
               
                   
                 vafnewftyfymdvwgngtqvtvssdkthtastkgpsvfplapsskstsg 
                   
               
               
                   
                 gtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvp 
                   
               
               
                   
                 ssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggps 
                   
               
               
                   
                 vflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhna 
                   
               
               
                   
                 ktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektisk 
                   
               
               
                   
                 akgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqp 
                   
               
               
                   
                 ennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhyt 
                   
               
               
                   
                 qkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 sdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsgs 
                 SEQ ID NO: 
               
               
                   
                 pdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtdfvlt 
                 132 
               
               
                   
                 qsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassrasg 
                   
               
               
                   
                 vpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkthtr 
                   
               
               
                   
                 tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesv 
                   
               
               
                   
                 teqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 17 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 133 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg 
                   
               
               
                   
                 ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg 
                   
               
               
                   
                 cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg 
                   
               
               
                   
                 accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag 
                   
               
               
                   
                 ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc 
                   
               
               
                   
                 cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc 
                   
               
               
                   
                 ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca 
                   
               
               
                   
                 attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg 
                   
               
               
                   
                 aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac 
                   
               
               
                   
                 tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc 
                   
               
               
                   
                 catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg 
                   
               
               
                   
                 cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt 
                   
               
               
                   
                 gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct 
                   
               
               
                   
                 tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgag 
                   
               
               
                   
                 cctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac 
                 SEQ ID NO: 
               
               
                   
                 agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 
                 134 
               
               
                   
                 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca 
                   
               
               
                   
                 agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac 
                   
               
               
                   
                 accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct 
                   
               
               
                   
                 actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaag 
                   
               
               
                   
                 cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc 
                   
               
               
                   
                 tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgc 
                   
               
               
                   
                 gaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca 
                   
               
               
                   
                 gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg 
                   
               
               
                   
                 agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgta 
                   
               
               
                   
                 cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt 
                   
               
               
                   
                 caaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga 
                 SEQ ID NO: 
               
               
                   
                 aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 
                 135 
               
               
                   
                 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc 
                   
               
               
                   
                 gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca 
                   
               
               
                   
                 gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc 
                   
               
               
                   
                 cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac 
                   
               
               
                   
                 gacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaacctgg 
                   
               
               
                   
                 aattctggggccagggcacagccgtgaccgtgtcatctgacaaaacccatacccag 
                   
               
               
                   
                 atgcagctgcaggagagcggccctggactcgtgaagcccagcgagaccctgagc 
                   
               
               
                   
                 ctgacatgcagcgtgagcggcgccagcatcagcgacagctactggagctggatca 
                   
               
               
                   
                 ggaggagccctggcaagggcctggagtggatcggctacgtgcacaagagcggcg 
                   
               
               
                   
                 acaccaactacagcccctccctgaagtccagggtgaacctgtccctggacaccagc 
                   
               
               
                   
                 aagaaccaggtgagcctgtccctggtggctgccacagctgctgacagcggcaagta 
                   
               
               
                   
                 ctactgtgccaggaccctgcacggcaggaggatctacggcatcgtggccttcaacg 
                   
               
               
                   
                 agtggttcacctacttctacatggacgtgtggggcaacggcacccaggtgaccgtga 
                   
               
               
                   
                 gctccgataagacccacaccgcttccaccaagggcccatcggtcttccccctggcac 
                   
               
               
                   
                 cctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaagga 
                   
               
               
                   
                 ctacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcg 
                   
               
               
                   
                 tgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggt 
                   
               
               
                   
                 gaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcaca 
                   
               
               
                   
                 agcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaact 
                   
               
               
                   
                 cacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctc 
                   
               
               
                   
                 ttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgc 
                   
               
               
                   
                 gtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtatgttgac 
                   
               
               
                   
                 ggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagc 
                   
               
               
                   
                 acgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaag 
                   
               
               
                   
                 gagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccat 
                   
               
               
                   
                 ctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatgc 
                   
               
               
                   
                 cgggatgagctgaccaagaatcaagtcagcctgtggtgcctggtaaaaggcttctat 
                   
               
               
                   
                 cccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactac 
                   
               
               
                   
                 aagaccacgcctcccgtgctggactccgacggctccttcttcctctactcaaaactca 
                   
               
               
                   
                 ccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcat 
                   
               
               
                   
                 gaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 tccgacatcagcgtggcccccggagagacagccaggatctcctgcggcga 
                 SEQ ID NO: 
               
               
                   
                 gaagagcctgggaagcagggctgtgcagtggtaccaacacagggccgga 
                 136 
               
               
                   
                 caggctcccagcctgatcatctacaacaaccaggacaggcccagcggcatc 
                   
               
               
                   
                 cctgagaggttcagcggaagccccgacagccccttcggaaccacagccac 
                   
               
               
                   
                 cctgaccatcacaagcgtggaagccggcgacgaggccgactactactgcc 
                   
               
               
                   
                 acatctgggacagcagggtgcccaccaagtgggtgtttggcggcggcacca 
                   
               
               
                   
                 ccctgaccgtgctggacaaaacccataccgacttcgtgctgacccagagccc 
                   
               
               
                   
                 tcacagcctgagcgtgacacctggcgagagcgccagcatcagctgcaaga 
                   
               
               
                   
                 gcagccactccctgatccacggcgaccggaacaactacctggcttggtacgt 
                   
               
               
                   
                 gcagaagcccggcagatccccccagctgctgatctacctggccagcagca 
                   
               
               
                   
                 gagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggact 
                   
               
               
                   
                 tcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactact 
                   
               
               
                   
                 gtatgcagggcagagagagcccctggacctttggccagggcaccaaggtg 
                   
               
               
                   
                 gacatcaaggataagacccatacccgtacggtggccgctcccagcgtgttca 
                   
               
               
                   
                 tcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtg 
                   
               
               
                   
                 cctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtgga 
                   
               
               
                   
                 caacgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggac 
                   
               
               
                   
                 agcaaggactccacctacagcctgagcagcaccctgacactgagcaaggc 
                   
               
               
                   
                 cgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggcc 
                   
               
               
                   
                 tgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 18 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq 
                 SEQ ID NO: 
               
               
                   
                 ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 
                 137 
               
               
                   
                 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn 
                   
               
               
                   
                 sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve 
                   
               
               
                   
                 pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp 
                   
               
               
                   
                 evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs 
                   
               
               
                   
                 nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealh 
                   
               
               
                   
                 nhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                 SEQ ID NO: 
               
               
                   
                 gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifp 
                 138 
               
               
                   
                 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lssltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 qmqlqesgpglvkpsetlsltcsvsgasisdsywswirrspgkglewigy 
                 SEQ ID NO: 
               
               
                   
                 vhksgdtnyspslksrynlsldtsknqvslslyaataadsgkyycartlhgrr 
                 139 
               
               
                   
                 iygivafnewftyfymdvwgngtqvtvssdkthtevrlvesggglvkpg 
                   
               
               
                   
                 gslrlscsasgfdfdnawmtwvrqppgkglewvgritgpgegwsvdya 
                   
               
               
                   
                 esvkgrftisrdntkntlylemnnvrtedtgyyfcartgkyydfwsgyppg 
                   
               
               
                   
                 eeyfqdwgqgtlvivssdkthtastkgpsvfplapsskstsggtaalgclvk 
                   
               
               
                   
                 dyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyic 
                   
               
               
                   
                 nynhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkd 
                   
               
               
                   
                 tlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqyn 
                   
               
               
                   
                 styrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepq 
                   
               
               
                   
                 vytlppcrdeltknqvslwclvkgfypsdiavewesngqpennykttpp 
                   
               
               
                   
                 vldsdgsfflyskltvdksrwqqgnyfscsvmhealhnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsg 
                 SEQ ID NO: 
               
               
                   
                 ipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthts 
                 140 
               
               
                   
                 disvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsgs 
                   
               
               
                   
                 pdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtrtvaa 
                   
               
               
                   
                 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd 
                   
               
               
                   
                 skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 18 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggaccg 
                 141 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg 
                   
               
               
                   
                 ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg 
                   
               
               
                   
                 cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg 
                   
               
               
                   
                 accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag 
                   
               
               
                   
                 ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc 
                   
               
               
                   
                 cttccgtgttcctgaccccccaaagcccaaggacaccctgatgatcagccggaccc 
                   
               
               
                   
                 ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca 
                   
               
               
                   
                 attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg 
                   
               
               
                   
                 aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac 
                   
               
               
                   
                 tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc 
                   
               
               
                   
                 catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg 
                   
               
               
                   
                 cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt 
                   
               
               
                   
                 gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct 
                   
               
               
                   
                 tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgag 
                   
               
               
                   
                 cctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac 
                 SEQ ID NO: 
               
               
                   
                 agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 
                 142 
               
               
                   
                 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca 
                   
               
               
                   
                 agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac 
                   
               
               
                   
                 accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct 
                   
               
               
                   
                 actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaag 
                   
               
               
                   
                 cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc 
                   
               
               
                   
                 tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgc 
                   
               
               
                   
                 gaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca 
                   
               
               
                   
                 gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg 
                   
               
               
                   
                 agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgta 
                   
               
               
                   
                 cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt 
                   
               
               
                   
                 caaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 cagatgcagctgcaggagagcggccctggactcgtgaagcccagcgagaccctg 
                 SEQ ID NO: 
               
               
                   
                 agcctgacatgcagcgtgagcggcgccagcatcagcgacagctactggagctgga 
                 143 
               
               
                   
                 tcaggaggagccctggcaagggcctggagtggatcggctacgtgcacaagagcg 
                   
               
               
                   
                 gcgacaccaactacagcccctccctgaagtccagggtgaacctgtccctggacacc 
                   
               
               
                   
                 agcaagaaccaggtgagcctgtccctggtggctgccacagctgctgacagcggca 
                   
               
               
                   
                 agtactactgtgccaggaccctgcacggcaggaggatctacggcatcgtggccttca 
                   
               
               
                   
                 acgagtggttcacctacttctacatggacgtgtggggcaacggcacccaggtgacc 
                   
               
               
                   
                 gtgagctccgacaaaacccataccgaggttagactggtggagtcaggaggggggc 
                   
               
               
                   
                 ttgtgaagcccggtgggtctctccgcctgagctgttctgcctccggctttgatttcgata 
                   
               
               
                   
                 acgcctggatgacctgggtcaggcagcctccaggtaagggactggagtgggtggg 
                   
               
               
                   
                 aagaatcacaggtccaggcgagggctggtccgtggactacgcggaatctgttaaag 
                   
               
               
                   
                 ggcggtttacaatctcaagggacaataccaagaataccttgtatttggagatgaacaa 
                   
               
               
                   
                 cgtgagaactgaagacaccggatattacttctgtgccagaacaggcaaatactacga 
                   
               
               
                   
                 cttctggtccggctatccccctggcgaggaatattttcaagactggggtcagggaacc 
                   
               
               
                   
                 cttgttatcgtgtcctccgataagacccacaccgcttccaccaagggcccatcggtctt 
                   
               
               
                   
                 ccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgc 
                   
               
               
                   
                 ctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccct 
                   
               
               
                   
                 gaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctc 
                   
               
               
                   
                 agcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatctt 
                   
               
               
                   
                 gtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggacc 
                   
               
               
                   
                 gtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccct 
                   
               
               
                   
                 gaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaa 
                   
               
               
                   
                 ctggtatgttgacggcgtggaggtgcataatgccaagacaaagccgcgggaggag 
                   
               
               
                   
                 cagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactg 
                   
               
               
                   
                 gctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagccccca 
                   
               
               
                   
                 tcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacac 
                   
               
               
                   
                 cctgcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctggt 
                   
               
               
                   
                 aaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccg 
                   
               
               
                   
                 gagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctct 
                   
               
               
                   
                 actcaaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgc 
                   
               
               
                   
                 tccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctc 
                   
               
               
                   
                 cgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactg 
                 SEQ ID NO: 
               
               
                   
                 tgactattacttgccgaggcgactcactgcggagccactacgcttcctggtatc 
                 144 
               
               
                   
                 agaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaata 
                   
               
               
                   
                 ggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc 
                   
               
               
                   
                 cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgc 
                   
               
               
                   
                 agctcccgggataagagcggctccagactgagcgtgttcggaggaggaact 
                   
               
               
                   
                 aaactgaccgtcctcgacaaaacccatacctccgacatcagcgtggccccc 
                   
               
               
                   
                 ggagagacagccaggatctcctgcggcgagaagagcctgggaagcaggg 
                   
               
               
                   
                 ctgtgcagtggtaccaacacagggccggacaggctcccagcctgatcatcta 
                   
               
               
                   
                 caacaaccaggacaggcccagcggcatccctgagaggttcagcggaagcc 
                   
               
               
                   
                 ccgacagccccttcggaaccacagccaccctgaccatcacaagcgtggaa 
                   
               
               
                   
                 gccggcgacgaggccgactactactgccacatctgggacagcagggtgcc 
                   
               
               
                   
                 caccaagtgggtgtttggcggcggcaccaccctgaccgtgctggataagac 
                   
               
               
                   
                 ccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacg 
                   
               
               
                   
                 agcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctac 
                   
               
               
                   
                 ccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg 
                   
               
               
                   
                 gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccaccta 
                   
               
               
                   
                 cagcctgagcagcaccctgacactgagcaaggccgactacgagaagcaca 
                   
               
               
                   
                 aggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgacca 
                   
               
               
                   
                 agagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 19 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgritgp 
                 SEQ ID NO: 
               
               
                   
                 gegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartgkyydfws 
                 145 
               
               
                   
                 gyppgeeyfqdwgqgtlvivss astkgpsvfplapsskstsggtaalgclvkdyfp   
                   
               
               
                   
                 
                   epvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsn 
                 
                   
               
               
                   
                 
                   tkvdkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvv 
                 
                   
               
               
                   
                 
                   vdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlng 
                 
                   
               
               
                   
                 
                   keykckvsnkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgf 
                 
                   
               
               
                   
                 
                   vpsdiavewesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscs 
                 
                   
               
               
                   
                 
                   vmhealhnhytqkslslspg 
                 
                   
               
               
                   
               
               
                 Light chain A 
                 aseltqdpaysvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsg 
                 SEQ ID NO: 
               
               
                   
                 ipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvlsqpka 
                 146 
               
               
                   
                 apsvtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvettlpskqs 
                   
               
               
                   
                 nnkyaassylsltpeqwkshrsyscqvthegstvektvaptecs 
                   
               
               
                   
               
               
                 Heavy chain B 
                 qmqlqesgpglvkpsetlsltcsvsgasisdsywswirrspgkglewigy 
                 SEQ ID NO: 
               
               
                   
                 vhksgdtnyspslksrvnlsldtsknqvslslvaataadsgkyycartlhgrr 
                 147 
               
               
                   
                 iygivafnewftyfymdvwgngtqvtvssdkthtQvhltqsgpevrkpg 
                   
               
               
                   
                 tsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkviver 
                   
               
               
                   
                 fkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddga 
                   
               
               
                   
                 lnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskstsg 
                   
               
               
                   
                 gtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvp 
                   
               
               
                   
                 ssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggps 
                   
               
               
                   
                 vflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhna 
                   
               
               
                   
                 ktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektisk 
                   
               
               
                   
                 akgqprepqvytlpperdeltknqvslwclvkgfypsdiavewesngqp 
                   
               
               
                   
                 ennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhyt 
                   
               
               
                   
                 qkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass 
                 SEQ ID NO: 
               
               
                   
                 rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikd 
                 148 
               
               
                   
                 kthtsdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiper 
                   
               
               
                   
                 fsgspdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtrt 
                   
               
               
                   
                 vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt 
                   
               
               
                   
                 eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 19 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 149 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtataggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc 
                   
               
               
                   
                 gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgcgtcga 
                   
               
               
                   
                 ccaagggccccagcgtgttccctctggcccctagcagcaagagcacatctggcgga 
                   
               
               
                   
                 acagccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcc 
                   
               
               
                   
                 tggaattctggcgccctgaccagcggcgtgcacacctaccagctgtgctgcagtcc 
                   
               
               
                   
                 agcggcctgtacagcctgagcagcgtcgtgacagtgcccagcagctctctgggcac 
                   
               
               
                   
                 ccagacctacatctgcaacgtgaaccacaagcccagcaacaccaaggtggacaag 
                   
               
               
                   
                 aaggtggaacccaagagctgcgacaagacccacacctgtcccccttgtcctgcccc 
                   
               
               
                   
                 cgaactgctgggaggcccttccgtgttcctgttccccccaaagcccaaggacaccct 
                   
               
               
                   
                 gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccacgagg 
                   
               
               
                   
                 accctgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaag 
                   
               
               
                   
                 accaagccaagagaggaacagtacaacagcacctaccgggtggtgtccgtgctga 
                   
               
               
                   
                 ccgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaa 
                   
               
               
                   
                 caaggccctgcctgcccccatcgagaaaaccatcagcaaggccaagggccagcc 
                   
               
               
                   
                 ccgcgaaccccaggtgtgcacactgcccccaagcagggacgagctgaccaagaa 
                   
               
               
                   
                 ccaggtgtccctgagctgtgccgtgaaaggcttctacccctccgatatcgccgtgga 
                   
               
               
                   
                 atgggagagcaacggccagcccgagaacaactacaagaccaccccccctgtgctg 
                   
               
               
                   
                 gacagcgacggctcattcttcctggtgtccaagctgacagtggacaagtcccggtgg 
                   
               
               
                   
                 cagcagggcaacgtgttcagctgctccgtgatgcacgaggccctgcacaaccacta 
                   
               
               
                   
                 cacccagaagtccctgagcctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactg 
                 SEQ ID NO: 
               
               
                   
                 tgactattacttgccgaggcgactcactgcggagccactacgcttcctggtatc 
                 150 
               
               
                   
                 agaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaata 
                   
               
               
                   
                 ggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc 
                   
               
               
                   
                 cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgc 
                   
               
               
                   
                 agctcccgggataagagcggctccagactgagcgtgttcggaggaggaact 
                   
               
               
                   
                 aaactgaccgtcctcagtcagcccaaggctgccccctcggtcactctgttccc 
                   
               
               
                   
                 gccctcgagtgaggagcncaagccaacaaggccacactggtgtgtctcata 
                   
               
               
                   
                 agtgacttctacccgggagccgtgacagtggcctggaaggcagatagcagc 
                   
               
               
                   
                 cccgtcaaggcgggagtggagaccaccacaccctccaaacaaagcaacaa 
                   
               
               
                   
                 caagtacgcggccagcagctacctgagcctgacgcctgagcagtggaagtc 
                   
               
               
                   
                 ccacagaagctacagctgccaggtcacgcatgaagggagcaccgtggaga 
                   
               
               
                   
                 agacagtggcccctacagaatgttca 
                   
               
               
                   
               
               
                 Heavy chain B 
                 cagatgcagctgcaggagagcggccctggactcgtgaagcccagcgagaccctg 
                 SEQ ID NO: 
               
               
                   
                 agcctgacatgcagcgtgagcggcgccagcatcagcgacagctactggagctgga 
                 151 
               
               
                   
                 tcaggaggagccctggcaagggcctggagtggatcggctacgtgcacaagagcg 
                   
               
               
                   
                 gcgacaccaactacagcccctccctgaagtccagggtgaacctgtccctggacacc 
                   
               
               
                   
                 agcaagaaccaggtgagcctgtccctggtggctgccacagctgctgacagcggca 
                   
               
               
                   
                 agtactactgtgccaggaccctgcacggcaggaggatctacggcatcgtggccttca 
                   
               
               
                   
                 acgagtggttcacctacttctacatggacgtgtggggcaacggcacccaggtgacc 
                   
               
               
                   
                 gtgagctccgacaaaacccatacccaggtgcacctgacacagagcggacccgaag 
                   
               
               
                   
                 tgcggaagcctggcacctctgtgaaggtgtcctgcaaggcccctggcaacaccctg 
                   
               
               
                   
                 aaaacctacgacctgcactgggtgcgcagcgtgccaggacagggactgcagtgga 
                   
               
               
                   
                 tgggctggatcagccacgagggcgacaagaaagtgatcgtggaacggttcaaggc 
                   
               
               
                   
                 caaagtgaccatcgactgggacagaagcaccaacaccgcctacctgcagctgagc 
                   
               
               
                   
                 ggcctgacctctggcgataccgccgtgtactactgcgccaagggcagcaagcacc 
                   
               
               
                   
                 ggctgagagactacgccctgtacgacgatgacggcgccctgaactgggccgtgga 
                   
               
               
                   
                 tgtggactacctgagcaacctggaattctggggccagggcacagccgtgaccgtgt 
                   
               
               
                   
                 catctgataagacccacaccgcttccaccaagggcccatcggtcttccccctggcac 
                   
               
               
                   
                 cctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaagga 
                   
               
               
                   
                 ctacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcg 
                   
               
               
                   
                 tgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggt 
                   
               
               
                   
                 gaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcaca 
                   
               
               
                   
                 agcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaact 
                   
               
               
                   
                 cacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctc 
                   
               
               
                   
                 ttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgc 
                   
               
               
                   
                 gtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtatgttgac 
                   
               
               
                   
                 ggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagc 
                   
               
               
                   
                 acgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaag 
                   
               
               
                   
                 gagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccat 
                   
               
               
                   
                 ctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatgc 
                   
               
               
                   
                 cgggatgagctgaccaagaatcaagtcagcctgtggtgcctggtaaaaggcttctat 
                   
               
               
                   
                 cccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactac 
                   
               
               
                   
                 aagaccacgcctcccgtgctggactccgacggctccttcttcctctactcaaaactca 
                   
               
               
                   
                 ccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcat 
                   
               
               
                   
                 gaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgag 
                 SEQ ID NO: 
               
               
                   
                 agcgccagcatcagctgcaagagcagccactccctgatccacggcgaccg 
                 152 
               
               
                   
                 gaacaactacctggcttggtacgtgcagaagcccggcagatccccccagct 
                   
               
               
                   
                 gctgatctacctggccagcagcagagccagcggcgtgcccgatagattttct 
                   
               
               
                   
                 ggcagcggcagcgacaaggacttcaccctgaagatcagccgggtggaaac 
                   
               
               
                   
                 cgaggacgtgggcacctactactgtatgcagggcagagagagcccctgga 
                   
               
               
                   
                 cctttggccagggcaccaaggtggacatcaaggacaaaacccatacctccg 
                   
               
               
                   
                 acatcagcgtggcccccggagagacagccaggatctcctgcggcgagaag 
                   
               
               
                   
                 agcctgggaagcagggctgtgcagtggtaccaacacagggccggacagg 
                   
               
               
                   
                 ctcccagcctgatcatctacaacaaccaggacaggcccagcggcatccctg 
                   
               
               
                   
                 agaggttcagcggaagccccgacagccccttcggaaccacagccaccctg 
                   
               
               
                   
                 accatcacaagcgtggaagccggcgacgaggccgactactactgccacatc 
                   
               
               
                   
                 tgggacagcagggtgcccaccaagtgggtgtttggcggcggcaccaccct 
                   
               
               
                   
                 gaccgtgctggataagacccatacccgtacggtggccgctcccagcgtgttc 
                   
               
               
                   
                 atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgt 
                   
               
               
                   
                 gcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtgg 
                   
               
               
                   
                 acaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcagga 
                   
               
               
                   
                 cagcaaggactccacctacagcctgagcagcaccctgacactgagcaagg 
                   
               
               
                   
                 ccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggc 
                   
               
               
                   
                 ctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 20 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq 
                 SEQ ID NO: 
               
               
                   
                 ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 
                 153 
               
               
                   
                 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn 
                   
               
               
                   
                 sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve 
                   
               
               
                   
                 pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp 
                   
               
               
                   
                 evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs 
                   
               
               
                   
                 nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhn 
                   
               
               
                   
                 hytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                 SEQ ID NO: 
               
               
                   
                 gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsflhikrtvaapsvfifpp 
                 154 
               
               
                   
                 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl 
                   
               
               
                   
                 sstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 qmqlqesgpglvkpsetlsltcsvsgasisdsywswirrspgkglewigy 
                 SEQ ID NO: 
               
               
                   
                 vhksgdtnyspslksrvnlsldtsknqvslslvaataadsgkyycartlhgrr 
                 155 
               
               
                   
                 iygivafnewftyfymdvwgngtqvtvssdkthtQvhltqsgpevrkpg 
                   
               
               
                   
                 tsykvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkviver 
                   
               
               
                   
                 fkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddga 
                   
               
               
                   
                 lnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskstsg 
                   
               
               
                   
                 gtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtyp 
                   
               
               
                   
                 ssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggps 
                   
               
               
                   
                 vflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyydgvevhna 
                   
               
               
                   
                 ktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektisk 
                   
               
               
                   
                 akgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqp 
                   
               
               
                   
                 ennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhyt 
                   
               
               
                   
                 qkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass 
                 SEQ ID NO: 
               
               
                   
                 rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikd 
                 156 
               
               
                   
                 kthtsdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiper 
                   
               
               
                   
                 fsgspdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtrt 
                   
               
               
                   
                 vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt 
                   
               
               
                   
                 eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 20 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 157 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg 
                   
               
               
                   
                 ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg 
                   
               
               
                   
                 cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg 
                   
               
               
                   
                 accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag 
                   
               
               
                   
                 ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc 
                   
               
               
                   
                 cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc 
                   
               
               
                   
                 ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttc 
                   
               
               
                   
                 aattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagag 
                   
               
               
                   
                 gaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccagga 
                   
               
               
                   
                 ctggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcc 
                   
               
               
                   
                 cccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtg 
                   
               
               
                   
                 tgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagct 
                   
               
               
                   
                 gtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggc 
                   
               
               
                   
                 cagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt 
                   
               
               
                   
                 cttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgtt 
                   
               
               
                   
                 cagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctga 
                   
               
               
                   
                 gcctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac 
                 SEQ ID NO: 
               
               
                   
                 agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 
                 158 
               
               
                   
                 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca 
                   
               
               
                   
                 agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac 
                   
               
               
                   
                 accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct 
                   
               
               
                   
                 actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaag 
                   
               
               
                   
                 cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc 
                   
               
               
                   
                 tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgc 
                   
               
               
                   
                 gaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca 
                   
               
               
                   
                 gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg 
                   
               
               
                   
                 agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgta 
                   
               
               
                   
                 cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt 
                   
               
               
                   
                 caaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 cagatgcagctgcaggagagcggccctggactcgtgaagcccagcgagaccctg 
                 SEQ ID NO: 
               
               
                   
                 agcctgacatgcagcgtgagcggcgccagcatcagcgacagctactggagctgga 
                 159 
               
               
                   
                 tcaggaggagccctggcaagggcctggagtggatcggctacgtgcacaagagcg 
                   
               
               
                   
                 gcgacaccaactacagcccctccctgaagtccagggtgaacctgtccctggacacc 
                   
               
               
                   
                 agcaagaaccaggtgagcctgtccctggtggctgccacagctgctgacagcggca 
                   
               
               
                   
                 agtactactgtgccaggaccctgcacggcaggaggatctacggcatcgtggccttc 
                   
               
               
                   
                 aacgagtggttcacctacttctacatggacgtgtggggcaacggcacccaggtgac 
                   
               
               
                   
                 cgtgagctccgacaaaacccatacccaggtgcacctgacacagagcggacccgaa 
                   
               
               
                   
                 gtgcggaagcctggcacctctgtgaaggtgtcctgcaaggcccctggcaacaccct 
                   
               
               
                   
                 gaaaacctacgacctgcactgggtgcgcagcgtgccaggacagggactgcagtgg 
                   
               
               
                   
                 atgggctggatcagccacgagggcgacaagaaagtgatcgtggaacggttcaagg 
                   
               
               
                   
                 ccaaagtgaccatcgactgggacagaagcaccaacaccgcctacctgcagctgag 
                   
               
               
                   
                 cggcctgacctctggcgataccgccgtgtactactgcgccaagggcagcaagcac 
                   
               
               
                   
                 cggctgagagactacgccctgtacgacgatgacggcgccctgaactgggccgtgg 
                   
               
               
                   
                 atgtggactacctgagcaacctggaattctggggccagggcacagccgtgaccgtg 
                   
               
               
                   
                 tcatctgataagacccacaccgcttccaccaagggcccatcggtcttccccctggca 
                   
               
               
                   
                 ccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaagg 
                   
               
               
                   
                 actacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggc 
                   
               
               
                   
                 gtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtgg 
                   
               
               
                   
                 tgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcaca 
                   
               
               
                   
                 agcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaact 
                   
               
               
                   
                 cacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctc 
                   
               
               
                   
                 ttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgc 
                   
               
               
                   
                 gtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtatgttgac 
                   
               
               
                   
                 ggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagc 
                   
               
               
                   
                 acgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaa 
                   
               
               
                   
                 ggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaacc 
                   
               
               
                   
                 atctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccat 
                   
               
               
                   
                 gccgggatgagctgaccaagaatcaagtcagcctgtggtgcctggtaaaaggcttct 
                   
               
               
                   
                 atcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaact 
                   
               
               
                   
                 acaagaccacgcctcccgtgctggactccgacggctccttcttcctctactcaaaact 
                   
               
               
                   
                 caccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgc 
                   
               
               
                   
                 atgaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgag 
                 SEQ ID NO: 
               
               
                   
                 agcgccagcatcagctgcaagagcagccactccctgatccacggcgaccg 
                 160 
               
               
                   
                 gaacaactacctggcttggtacgtgcagaagcccggcagatccccccagct 
                   
               
               
                   
                 gctgatctacctggccagcagcagagccagcggcgtgcccgatagattttct 
                   
               
               
                   
                 ggcagcggcagcgacaaggacttcaccctgaagatcagccgggtggaaac 
                   
               
               
                   
                 cgaggacgtgggcacctactactgtatgcagggcagagagagcccctgga 
                   
               
               
                   
                 cctttggccagggcaccaaggtggacatcaaggacaaaacccatacctccg 
                   
               
               
                   
                 acatcagcgtggcccccggagagacagccaggatctcctgcggcgagaag 
                   
               
               
                   
                 agcctgggaagcagggctgtgcagtggtaccaacacagggccggacagg 
                   
               
               
                   
                 ctcccagcctgatcatctacaacaaccaggacaggcccagcggcatccctg 
                   
               
               
                   
                 agaggttcagcggaagccccgacagccccttcggaaccacagccaccctg 
                   
               
               
                   
                 accatcacaagcgtggaagccggcgacgaggccgactactactgccacatc 
                   
               
               
                   
                 tgggacagcagggtgcccaccaagtgggtgtttggcggcggcaccaccct 
                   
               
               
                   
                 gaccgtgctggataagacccatacccgtacggtggccgctcccagcgtgttc 
                   
               
               
                   
                 atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgt 
                   
               
               
                   
                 gcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtgg 
                   
               
               
                   
                 acaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcagga 
                   
               
               
                   
                 cagcaaggactccacctacagcctgagcagcaccctgacactgagcaagg 
                   
               
               
                   
                 ccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggc 
                   
               
               
                   
                 ctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 21 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 qvhltqsgpevrkpgtsvkvsckapgntlktydlhwyrsvpgqglqwmgwish 
                 SEQ ID NO: 
               
               
                   
                 egdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyaly 
                 161 
               
               
                   
                 dddgalnwavdvdylsnlefwgqgtavtvssastkgpsvfplapsskstsggtaal 
                   
               
               
                   
                 gclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyi 
                   
               
               
                   
                 cnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmi 
                   
               
               
                   
                 srtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreegynstyrvvsvlt 
                   
               
               
                   
                 vlhqdwlngkeykckvsnkalpapiektiskakgqprepqvctlppsrdeltknq 
                   
               
               
                   
                 vslscavkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrw 
                   
               
               
                   
                 qqgnvfscsvmhealhnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass 
                 SEQ ID NO: 
               
               
                   
                 rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrt 
                 162 
               
               
                   
                 vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt 
                   
               
               
                   
                 eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv 
                 SEQ ID NO: 
               
               
                   
                 gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 
                 163 
               
               
                   
                 tgkyydfwsgyppgeeyfqdwgqgtlvivssdktht 
                   
               
               
                   
                 rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgw 
                   
               
               
                   
                 ikpqygavnfgggfrdrytltrdvyreiaymdirglkpddtavyycardrs 
                   
               
               
                   
                 ygdsswaldawgqgttvvvsadkthtastkgpsvfplapsskstsggtaal 
                   
               
               
                   
                 gclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslg 
                   
               
               
                   
                 tqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfp 
                   
               
               
                   
                 pkpkddmisrtpevtcvvvdvshedpevkfnwyydgvevhnaktkpr 
                   
               
               
                   
                 eeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgq 
                   
               
               
                   
                 prepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpenny 
                   
               
               
                   
                 kttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqksls 
                   
               
               
                   
                 lspg 
                   
               
               
                   
               
               
                 Light chain B 
                 yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                 SEQ ID NO: 
               
               
                   
                 gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikdkthtaseltqd 
                 164 
               
               
                   
                 pavsvalkqtvtitcrgdskshyaswyqkkpgqapvllfygknnrpsgipdrfsg 
                   
               
               
                   
                 sasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtvaapsv 
                   
               
               
                   
                 fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskd 
                   
               
               
                   
                 styslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 21 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga 
                 SEQ ID NO: 
               
               
                   
                 aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 
                 165 
               
               
                   
                 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc 
                   
               
               
                   
                 gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca 
                   
               
               
                   
                 gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc 
                   
               
               
                   
                 cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac 
                   
               
               
                   
                 gacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaacctgg 
                   
               
               
                   
                 aattctggggccagggcacagccgtgaccgtgtcatctgcttcgaccaagggcccc 
                   
               
               
                   
                 agcgtgttccctctggcccctagcagcaagagcacatctggcggaacagccgccct 
                   
               
               
                   
                 gggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggc 
                   
               
               
                   
                 gccctgaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtac 
                   
               
               
                   
                 agcctgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacat 
                   
               
               
                   
                 ctgcaacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacc 
                   
               
               
                   
                 caagagctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgg 
                   
               
               
                   
                 gaggcccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagcc 
                   
               
               
                   
                 ggacccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtg 
                   
               
               
                   
                 aagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaa 
                   
               
               
                   
                 gagaggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcac 
                   
               
               
                   
                 caggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgc 
                   
               
               
                   
                 ctgcccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaacccc 
                   
               
               
                   
                 aggtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccct 
                   
               
               
                   
                 gagctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagca 
                   
               
               
                   
                 acggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacg 
                   
               
               
                   
                 gctcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggca 
                   
               
               
                   
                 acgtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagt 
                   
               
               
                   
                 ccctgagcctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg 
                 SEQ ID NO: 
               
               
                   
                 ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                 166 
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc 
                   
               
               
                   
                 cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg 
                   
               
               
                   
                 tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc 
                   
               
               
                   
                 aagcgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctg 
                   
               
               
                   
                 aagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcc 
                   
               
               
                   
                 aaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagc 
                   
               
               
                   
                 gtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgacac 
                   
               
               
                   
                 tgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccacca 
                   
               
               
                   
                 gggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 167 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc 
                   
               
               
                   
                 gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa 
                   
               
               
                   
                 cccataccagagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgc 
                   
               
               
                   
                 ctctgtgcgggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttct 
                   
               
               
                   
                 ggttccggcaggcccctggcagaggactggaatgggtgggatggatcaagcccca 
                   
               
               
                   
                 gtatggcgccgtgaacttcggcggaggcttccgggatagagtgaccctgacccggg 
                   
               
               
                   
                 acgtgtaccgcgagatcgcctacatggacatccggggcctgaagcccgatgacacc 
                   
               
               
                   
                 gccgtgtactactgcgccagagacagaagctacggcgacagcagctgggctctgg 
                   
               
               
                   
                 atgcttggggccagggcacaaccgtggtggtgtctgccgataagacccacaccgct 
                   
               
               
                   
                 tccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctggg 
                   
               
               
                   
                 ggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggt 
                   
               
               
                   
                 gtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctac 
                   
               
               
                   
                 agtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgg 
                   
               
               
                   
                 gcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtgga 
                   
               
               
                   
                 caagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagc 
                   
               
               
                   
                 acctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacac 
                   
               
               
                   
                 cctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacg 
                   
               
               
                   
                 aagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataatgcca 
                   
               
               
                   
                 agacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcct 
                   
               
               
                   
                 caccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctcca 
                   
               
               
                   
                 acaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagcc 
                   
               
               
                   
                 ccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgaccaagaat 
                   
               
               
                   
                 caagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgtggag 
                   
               
               
                   
                 tgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctgg 
                   
               
               
                   
                 actccgacggctccttcttcctctactcaaaactcaccgtggacaagagcaggtggca 
                   
               
               
                   
                 gcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacac 
                   
               
               
                   
                 gcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt 
                 SEQ ID NO: 
               
               
                   
                 gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 
                 168 
               
               
                   
                 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga 
                   
               
               
                   
                 tggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccat 
                   
               
               
                   
                 cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc 
                   
               
               
                   
                 ggcagaggcagcagactgcacatcaaggacaaaacccataccgcatccgaactga 
                   
               
               
                   
                 ctcaggaccctgccgtctctgtggcactgaagcagactgtgactattacttgccgagg 
                   
               
               
                   
                 cgactcactgcggagccactacgcttcctggtatcagaagaaacccggccaggcac 
                   
               
               
                   
                 ctgtgctgctgttctacggaaagaacaataggccatctggcatccccgaccgcttttct 
                   
               
               
                   
                 ggcagtgcatcagggaaccgagccagtctgaccattaccggcgcccaggctgagg 
                   
               
               
                   
                 acgaagccgattactattgcagctcccgggataagagcggctccagactgagcgtgt 
                   
               
               
                   
                 tcggaggaggaactaaactgaccgtcctcgataagacccatacccgtacggtggcc 
                   
               
               
                   
                 gctcccagcgtgacatcttcccacctagcgacgagcagctgaagtccggcacagcc 
                   
               
               
                   
                 tctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaag 
                   
               
               
                   
                 gtggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcagga 
                   
               
               
                   
                 cagcaaggactccacctacagcctgagcagcaccctgacactgagcaaggccgac 
                   
               
               
                   
                 tacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccc 
                   
               
               
                   
                 cgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 22 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwish 
                 SEQ ID NO: 
               
               
                   
                 egdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyaly 
                 169 
               
               
                   
                 dddgalnwavdvdylsnlefwgqgtavtvssastkgpsvfplapsskstsggtaal 
                   
               
               
                   
                 gclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyi 
                   
               
               
                   
                 cnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmi 
                   
               
               
                   
                 srtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvlt 
                   
               
               
                   
                 vlhqdwlngkeykckvsnkalpapiektiskakgqprepqvctlppsrdeltknq 
                   
               
               
                   
                 vslscavkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrw 
                   
               
               
                   
                 qqgnvfscsvmhealhnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass 
                 SEQ ID NO: 
               
               
                   
                 rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrt 
                 170 
               
               
                   
                 vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt 
                   
               
               
                   
                 eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 rahlyqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgw 
                 SEQ ID NO: 
               
               
                   
                 ikpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrs 
                 171 
               
               
                   
                 ygdsswaldawgqgttvvvsadkthtevrlvesggglvkpggslrlscsas 
                   
               
               
                   
                 gfdfdnawmtwvrqppgkglewvgritgpgegwsvdyaesvkgrftis 
                   
               
               
                   
                 rdntkntlylemnnvrtedtgyyfcartgkyydfwsgyppgeeyfqdwg 
                   
               
               
                   
                 qgtlvivssdkthtastkgpsvfplapsskstsggtaalgclvkdyfpepvtv 
                   
               
               
                   
                 swnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsnt 
                   
               
               
                   
                 kvdkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevt 
                   
               
               
                   
                 cvvvdvshedpevkfnwyydgvevhnaktkpreeqynstyrvvsvltvl 
                   
               
               
                   
                 hqdwlngkeykckvsnkalpapiektiskakgqprepqvytlpperdelt 
                   
               
               
                   
                 knqvslwclvkgfypsdiavewesngqpennykttppyldsdgsf 
                   
               
               
                   
               
               
                 Light chain B 
                 aseltqdpaysvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsg 
                 SEQ ID NO: 
               
               
                   
                 ipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvl dktht 
                 172 
               
               
                   
                 Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                   
               
               
                   
                 gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhik 
                   
               
               
                   
                 dkthtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgn 
                   
               
               
                   
                 sqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 22 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga 
                 SEQ ID NO: 
               
               
                   
                 aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 
                 173 
               
               
                   
                 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc 
                   
               
               
                   
                 gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca 
                   
               
               
                   
                 gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc 
                   
               
               
                   
                 cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac 
                   
               
               
                   
                 gacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaacctgg 
                   
               
               
                   
                 aattctggggccagggcacagccgtgaccgtgtcatctgcttcgaccaagggcccc 
                   
               
               
                   
                 agcgtgttccctctggcccctagcagcaagagcacatctggcggaacagccgccct 
                   
               
               
                   
                 gggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggc 
                   
               
               
                   
                 gccctgaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtac 
                   
               
               
                   
                 agcctgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacat 
                   
               
               
                   
                 ctgcaacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacc 
                   
               
               
                   
                 caagagctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgg 
                   
               
               
                   
                 gaggcccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagcc 
                   
               
               
                   
                 ggacccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtg 
                   
               
               
                   
                 aagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaa 
                   
               
               
                   
                 gagaggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcac 
                   
               
               
                   
                 caggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgc 
                   
               
               
                   
                 ctgcccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaacccc 
                   
               
               
                   
                 aggtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccct 
                   
               
               
                   
                 gagctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagca 
                   
               
               
                   
                 acggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacg 
                   
               
               
                   
                 gctcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggca 
                   
               
               
                   
                 acgtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagt 
                   
               
               
                   
                 ccctgagcctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg 
                 SEQ ID NO: 
               
               
                   
                 ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                 174 
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc 
                   
               
               
                   
                 cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg 
                   
               
               
                   
                 tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc 
                   
               
               
                   
                 aagcgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctg 
                   
               
               
                   
                 aagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcc 
                   
               
               
                   
                 aaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagc 
                   
               
               
                   
                 gtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgacac 
                   
               
               
                   
                 tgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccacca 
                   
               
               
                   
                 gggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 175 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgacaaaacccataccgaggttaga 
                   
               
               
                   
                 ctggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgcctgagctg 
                   
               
               
                   
                 ttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggcagcctccag 
                   
               
               
                   
                 gtaagggactggagtgggtgggaagaatcacaggtccaggcgagggctggtccgt 
                   
               
               
                   
                 ggactacgcggaatctgttaaagggcggtttacaatctcaagggacaataccaagaa 
                   
               
               
                   
                 taccttgtatttggagatgaacaacgtgagaactgaagacaccggatattacttctgtg 
                   
               
               
                   
                 ccagaacaggcaaatactacgacttctggtccggctatccccctggcgaggaatattt 
                   
               
               
                   
                 tcaagactggggtcagggaacccttgttatcgtgtcctccgataagacccacaccgct 
                   
               
               
                   
                 tccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctggg 
                   
               
               
                   
                 ggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggt 
                   
               
               
                   
                 gtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctac 
                   
               
               
                   
                 agtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgg 
                   
               
               
                   
                 gcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtgga 
                   
               
               
                   
                 caagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagc 
                   
               
               
                   
                 acctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacac 
                   
               
               
                   
                 cctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacg 
                   
               
               
                   
                 aagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataatgcca 
                   
               
               
                   
                 agacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcct 
                   
               
               
                   
                 caccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctcca 
                   
               
               
                   
                 acaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagcc 
                   
               
               
                   
                 ccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgaccaagaat 
                   
               
               
                   
                 caagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgtggag 
                   
               
               
                   
                 tgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctgg 
                   
               
               
                   
                 actccgacggctccttcttcctctactcaaaactcaccgtggacaagagcaggtggca 
                   
               
               
                   
                 gcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacac 
                   
               
               
                   
                 gcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactg 
                 SEQ ID NO: 
               
               
                   
                 tgactattacttgccgaggcgactcactgcggagccactacgcttcctggtatc 
                 176 
               
               
                   
                 agaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaata 
                   
               
               
                   
                 ggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc 
                   
               
               
                   
                 cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgc 
                   
               
               
                   
                 agctcccgggataagagcggctccagactgagcgtgttcggaggaggaact 
                   
               
               
                   
                 aaactgaccgtcctcgacaaaacccatacctacatccacgtgacccagagcc 
                   
               
               
                   
                 ccagcagcctgtccgtgtccatcggcgacagagtgaccatcaactgccaga 
                   
               
               
                   
                 cctctcagggcgtgggcagcgacctgcactggtatcagcacaagcctggca 
                   
               
               
                   
                 gagcccccaagctgctgatccaccacacaagcagcgtggaagatggcgtg 
                   
               
               
                   
                 cccagcagattttccggcagcggcttccacaccagcttcaacctgaccatca 
                   
               
               
                   
                 gcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttc 
                   
               
               
                   
                 ttcggcagaggcagcagactgcacatcaaggataagacccatacccgtacg 
                   
               
               
                   
                 gtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagt 
                   
               
               
                   
                 ccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggc 
                   
               
               
                   
                 caaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccag 
                   
               
               
                   
                 gaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcag 
                   
               
               
                   
                 caccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcct 
                   
               
               
                   
                 gcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaacc 
                   
               
               
                   
                 ggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 23 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgritgp 
                 SEQ ID NO: 
               
               
                   
                 gegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartgkyydfws 
                 177 
               
               
                   
                 gyppgeeyfqdwgqgtlvivssastkgpsvfplapsskstsggtaalgclvkdyfp 
                   
               
               
                   
                 epvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsn 
                   
               
               
                   
                 tkvdkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvv 
                   
               
               
                   
                 vdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsyltvlhqdwlng 
                   
               
               
                   
                 keykckvsnkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgf 
                   
               
               
                   
                 ypsdiavewesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscs 
                   
               
               
                   
                 vmhealhnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 Aseltqdpaysvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrps 
                 SEQ ID NO: 
               
               
                   
                 gipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvlsqpk 
                 178 
               
               
                   
                 aapsvtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpsk 
                   
               
               
                   
                 qsnnkyaassylsltpeqwkshrsyscqvthegstvektvaptecs 
                   
               
               
                   
               
               
                 Heavy chain B 
                 rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgw 
                 SEQ ID NO: 
               
               
                   
                 ikpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrs 
                 179 
               
               
                   
                 ygdsswaldawgqgttvvvsadkthtQvhltqsgpevrkpgtsvkvsck 
                   
               
               
                   
                 apgntlktydlhwvrsvpgqglqwmgwishegdkkviverfkakvtid 
                   
               
               
                   
                 wdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddgalnwavd 
                   
               
               
                   
                 vdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskstsggtaalgcl 
                   
               
               
                   
                 vkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqt 
                   
               
               
                   
                 yicnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppk 
                   
               
               
                   
                 pkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpree 
                   
               
               
                   
                 qynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqpr 
                   
               
               
                   
                 epqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpennyktt 
                   
               
               
                   
                 ppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslsls 
                   
               
               
                   
                 pg 
                   
               
               
                   
               
               
                 Light chain B 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas 
                 SEQ ID NO: 
               
               
                   
                 srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik 
                 180 
               
               
                   
                 dktht 
                   
               
               
                   
                 yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                   
               
               
                   
                 gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikdkthtrtvaaps 
                   
               
               
                   
                 vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk 
                   
               
               
                   
                 dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 23 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgactgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 181 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc 
                   
               
               
                   
                 gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgcgtcga 
                   
               
               
                   
                 ccaagggccccagcgtgttccctctggcccctagcagcaagagcacatctggcgga 
                   
               
               
                   
                 acagccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcc 
                   
               
               
                   
                 tggaattctggcgccctgaccagcggcgtgcacacctttccagctgtgctgcagtcc 
                   
               
               
                   
                 agcggcctgtacagcctgagcagcgtcgtgacagtgcccagcagctctctgggcac 
                   
               
               
                   
                 ccagacctacatctgcaacgtgaaccacaagcccagcaacaccaaggtggacaag 
                   
               
               
                   
                 aaggtggaacccaagagctgcgacaagacccacacctgtcccccttgtcctgcccc 
                   
               
               
                   
                 cgaactgctgggaggcccttccgtgttcctgttccccccaaagcccaaggacaccct 
                   
               
               
                   
                 gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccacgagg 
                   
               
               
                   
                 accctgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaag 
                   
               
               
                   
                 accaagccaagagaggaacagtacaacagcacctaccgggtggtgtccgtgctga 
                   
               
               
                   
                 ccgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaa 
                   
               
               
                   
                 caaggccctgcctgcccccatcgagaaaaccatcagcaaggccaagggccagcc 
                   
               
               
                   
                 ccgcgaaccccaggtgtgcacactgcccccaagcagggacgagctgaccaagaa 
                   
               
               
                   
                 ccaggtgtccctgagctgtgccgtgaaaggcttctacccctccgatatcgccgtgga 
                   
               
               
                   
                 atgggagagcaacggccagcccgagaacaactacaagaccaccccccctgtgctg 
                   
               
               
                   
                 gacagcgacggctcattcttcctggtgtccaagctgacagtggacaagtcccggtgg 
                   
               
               
                   
                 cagcagggcaacgtgttcagctgctccgtgatgcacgaggccctgcacaaccacta 
                   
               
               
                   
                 cacccagaagtccctgagcctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactg 
                 SEQ ID NO: 
               
               
                   
                 tgactattacttgccgaggcgactcactgcggagccactacgcttcctggtatc 
                 182 
               
               
                   
                 agaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaata 
                   
               
               
                   
                 ggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc 
                   
               
               
                   
                 cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgc 
                   
               
               
                   
                 agctcccgggataagagcggctccagactgagcgtgttcggaggaggaact 
                   
               
               
                   
                 aaactgaccgtcctcagtcagcccaaggctgccccctcggtcactctgttccc 
                   
               
               
                   
                 gccctcgagtgaggagcttcaagccaacaaggccacactggtgtgtctcata 
                   
               
               
                   
                 agtgacttctacccgggagccgtgacagtggcctggaaggcagatagcagc 
                   
               
               
                   
                 cccgtcaaggcgggagtggagaccaccacaccctccaaacaaagcaacaa 
                   
               
               
                   
                 caagtacgcggccagcagctacctgagcctgacgcctgagcagtggaagtc 
                   
               
               
                   
                 ccacagaagctacagctgccaggtcacgcatgaagggagcaccgtggaga 
                   
               
               
                   
                 agacagtggcccctacagaatgttca 
                   
               
               
                   
               
               
                 Heavy chain B 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 183 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgacaaaacccatacccaggtgcac 
                   
               
               
                   
                 ctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaaggtgtcctg 
                   
               
               
                   
                 caaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgcagcgtg 
                   
               
               
                   
                 ccaggacagggactgcagtggatgggctggatcagccacgagggcgacaagaaa 
                   
               
               
                   
                 gtgatcgtggaacggttcaaggccaaagtgaccatcgactgggacagaagcacca 
                   
               
               
                   
                 acaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactact 
                   
               
               
                   
                 gcgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacg 
                   
               
               
                   
                 gcgccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggc 
                   
               
               
                   
                 cagggcacagccgtgaccgtgtcatctgataagacccacaccgcttccaccaaggg 
                   
               
               
                   
                 cccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcgg 
                   
               
               
                   
                 ccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaact 
                   
               
               
                   
                 caggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcagga 
                   
               
               
                   
                 ctctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacc 
                   
               
               
                   
                 tacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttga 
                   
               
               
                   
                 gcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcct 
                   
               
               
                   
                 ggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctc 
                   
               
               
                   
                 ccggacccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgag 
                   
               
               
                   
                 gtcaagttcaactggtatgttgacggcgtggaggtgcataatgccaagacaaagccg 
                   
               
               
                   
                 cgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgca 
                   
               
               
                   
                 ccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcc 
                   
               
               
                   
                 cagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccac 
                   
               
               
                   
                 aggtgtacaccctgcccccatgccgggatgagctgaccaagaatcaagtcagcctg 
                   
               
               
                   
                 tggtgcctggtaaaaggcttctatcccagcgacatcgccgtggagtgggagagcaat 
                   
               
               
                   
                 gggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggct 
                   
               
               
                   
                 ccttcttcctctactcaaaactcaccgtggacaagagcaggtggcagcaggggaac 
                   
               
               
                   
                 gtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagc 
                   
               
               
                   
                 ctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgag 
                 SEQ ID NO: 
               
               
                   
                 agcgccagcatcagctgcaagagcagccactccctgatccacggcgaccg 
                 184 
               
               
                   
                 gaacaactacctggcttggtacgtgcagaagcccggcagatccccccagct 
                   
               
               
                   
                 gctgatctacctggccagcagcagagccagcggcgtgcccgatagattttct 
                   
               
               
                   
                 ggcagcggcagcgacaaggacttcaccctgaagatcagccgggtggaaac 
                   
               
               
                   
                 cgaggacgtgggcacctactactgtatgcagggcagagagagcccctgga 
                   
               
               
                   
                 cctttggccagggcaccaaggtggacatcaaggacaaaacccatacctacat 
                   
               
               
                   
                 ccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt 
                   
               
               
                   
                 gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggta 
                   
               
               
                   
                 tcagcacaagcctggcagagcccccaagctgctgatccaccacacaagca 
                   
               
               
                   
                 gcgtggaagatggcgtgcccagcagattttccggcagcggcttccacacca 
                   
               
               
                   
                 gcttcaacctgaccatcagcgatctgcaggccgacgacattgccacctactat 
                   
               
               
                   
                 tgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaaggata 
                   
               
               
                   
                 agacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagc 
                   
               
               
                   
                 gacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact 
                   
               
               
                   
                 tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcag 
                   
               
               
                   
                 agcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactcca 
                   
               
               
                   
                 cctacagcctgagcagcaccctgacactgagcaaggccgactacgagaag 
                   
               
               
                   
                 cacaaggtgtacgcctgcgaagtgacccaccagggcctgictagccccgtg 
                   
               
               
                   
                 accaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 24 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgritgpg 
                 SEQ ID 
               
               
                   
                 egwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartgkyydfwsgy 
                 NO: 185 
               
               
                   
                 ppgeeyfqdwgqgtlvivssastkgpsvfplapsskstsggtaalgclvkdyfpep 
                   
               
               
                   
                 vtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkv 
                   
               
               
                   
                 dkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvs 
                   
               
               
                   
                 hedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeyk 
                   
               
               
                   
                 ckvsnkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdi 
                   
               
               
                   
                 avewesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhea 
                   
               
               
                   
                 lhnhytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgi 
                 SEQ ID 
               
               
                   
                 pdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvlsqpkaa 
                 NO: 186 
               
               
                   
                 psvtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsn 
                   
               
               
                   
                 nkyaassylsltpeqwkshrsyscqvthegstvektvaptecs 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvhltqsgpevrkpgtsvkvsckapgnlktydlhwvrsvpgqglqwmg 
                 SEQ ID 
               
               
                   
                 wishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgsk 
                 NO: 187 
               
               
                   
                 hrlrdyalydddgalnwavdvdylsnlefwgqgtavtvss 
                   
               
               
                   
                 dkthtrahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglew 
                   
               
               
                   
                 vgwikpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycar 
                   
               
               
                   
                 drsygdsswaldawgqgttvvvsadkthtastkgpsvfplapsskstsggta 
                   
               
               
                   
                 algclykdyfpepvtvswnsgaltsgyhtfpavlqssglyslssvvtvpsssl 
                   
               
               
                   
                 gtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfp 
                   
               
               
                   
                 pkpkdtlmisrtpevtcvvvdvshedpevkfnwyydgvevhnaktkpre 
                   
               
               
                   
                 eqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqpr 
                   
               
               
                   
                 epqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpennyktt 
                   
               
               
                   
                 ppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslsp 
                   
               
               
                   
                 g 
                   
               
               
                   
               
               
                 Light chain B 
                 yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg 
                 SEQ ID 
               
               
                   
                 vpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikdkthtdfvltqsph 
                 NO: 188 
               
               
                   
                 slsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassrasgvpdrf 
                   
               
               
                   
                 sgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkthtrtvaaps 
                   
               
               
                   
                 vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskd 
                   
               
               
                   
                 styslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 24 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgc 
                 SEQ ID 
               
               
                   
                 ctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggca 
                 NO: 189 
               
               
                   
                 gcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagggc 
                   
               
               
                   
                 tggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaata 
                   
               
               
                   
                 ccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggatattac 
                   
               
               
                   
                 ttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggcgagg 
                   
               
               
                   
                 aatattttcaagactggggtcagggaacccttgttatcgtgtcctccgcgtcgaccaag 
                   
               
               
                   
                 ggccccagcgtgttccctctggcccctagcagcaagagcacatctggcggaacagc 
                   
               
               
                   
                 cgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaat 
                   
               
               
                   
                 tctggcgccctgaccagcggcgtgcacacctttccagctgtgctgcagtccagcggc 
                   
               
               
                   
                 ctgtacagcctgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacc 
                   
               
               
                   
                 tacatctgcaacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtgga 
                   
               
               
                   
                 acccaagagctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgct 
                   
               
               
                   
                 gggaggcccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagc 
                   
               
               
                   
                 cggacccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagt 
                   
               
               
                   
                 gaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaa 
                   
               
               
                   
                 gagaggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcac 
                   
               
               
                   
                 caggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcc 
                   
               
               
                   
                 tgcccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccag 
                   
               
               
                   
                 gtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgag 
                   
               
               
                   
                 ctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacgg 
                   
               
               
                   
                 ccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcat 
                   
               
               
                   
                 tcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgtt 
                   
               
               
                   
                 cagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgag 
                   
               
               
                   
                 cctgagccccggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactgt 
                 SEQ ID 
               
               
                   
                 gactattacttgccgaggcgactcactgcggagccactacgcttcctggtatca 
                 NO: 190 
               
               
                   
                 gaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaatagg 
                   
               
               
                   
                 ccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagccag 
                   
               
               
                   
                 tctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagct 
                   
               
               
                   
                 cccgggataagagcggctccagactgagcgtgttcggaggaggaactaaac 
                   
               
               
                   
                 tgaccgtcctcagtcagcccaaggctgccccctcggtcactctgttcccgccct 
                   
               
               
                   
                 cgagtgaggagcttcaagccaacaaggccacactggtgtgtctcataagtgac 
                   
               
               
                   
                 ttctacccgggagccgtgacagtggcctggaaggcagatagcagccccgtca 
                   
               
               
                   
                 aggcgggagtggagaccaccacaccctccaaacaaagcaacaacaagtac 
                   
               
               
                   
                 gcggccagcagctacctgagcctgacgcctgagcagtggaagtcccacaga 
                   
               
               
                   
                 agctacagctgccaggtcacgcatgaagggagcaccgtggagaagacagtg 
                   
               
               
                   
                 gcccctacagaatgttca 
                   
               
               
                   
               
               
                 Heavy chain B 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagtg 
                 SEQ ID 
               
               
                   
                 accatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagcac 
                 NO: 191 
               
               
                   
                 aagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagatgg 
                   
               
               
                   
                 cgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcagc 
                   
               
               
                   
                 gatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcag 
                   
               
               
                   
                 aggcagcagactgcacatcaaggacaaaacccataccgacttcgtgctgacccaga 
                   
               
               
                   
                 gccctcacagcctgagcgtgacacctggcgagagcgccagcatcagctgcaagag 
                   
               
               
                   
                 cagccactccctgatccacggcgaccggaacaactacctggcttggtacgtgcagaa 
                   
               
               
                   
                 gcccggcagatccccccagctgctgatctacctggccagcagcagagccagcggc 
                   
               
               
                   
                 gtgcccgatagattttctggcagcggcagcgacaaggacttcaccctgaagatcagc 
                   
               
               
                   
                 cgggtggaaaccgaggacgtgggcacctactactgtatgcagggcagagagagcc 
                   
               
               
                   
                 cctggacctttggccagggcaccaaggtggacatcaaggataagacccatacccgta 
                   
               
               
                   
                 cggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccg 
                   
               
               
                   
                 gcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgca 
                   
               
               
                   
                 gtggaaggtggacaacgccctgcagagcggcaacagccaggaaagcgtgaccga 
                   
               
               
                   
                 gcaggacagcaaggactccacctacagcctgagcagcaccctgacactgagcaag 
                   
               
               
                   
                 gccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtc 
                   
               
               
                   
                 tagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Light chain B 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgaca 
                 SEQ ID 
               
               
                   
                 gagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcactg 
                 NO: 192 
               
               
                   
                 gtatcagcacaagcctggcagagcccccaagctgctgatccaccacacaagc 
                   
               
               
                   
                 agcgtggaagatggcgtgcccagcagattttccggcagcggcttccacacca 
                   
               
               
                   
                 gcttcaacctgaccatcagcgatctgcaggccgacgacattgccacctactatt 
                   
               
               
                   
                 gtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaaggacaa 
                   
               
               
                   
                 aacccataccgacttcgtgctgacccagagccctcacagcctgagcgtgaca 
                   
               
               
                   
                 cctggcgagagcgccagcatcagctgcaagagcagccactccctgatccac 
                   
               
               
                   
                 ggcgaccggaacaactacctggcttggtacgtgcagaagcccggcagatcc 
                   
               
               
                   
                 ccccagctgctgatctacctggccagcagcagagccagcggcgtgcccgat 
                   
               
               
                   
                 agattttctggcagcggcagcgacaaggacttcaccctgaagatcagccggg 
                   
               
               
                   
                 tggaaaccgaggacgtgggcacctactactgtatgcagggcagagagagcc 
                   
               
               
                   
                 cctggacctttggccagggcaccaaggtggacatcaaggataagacccatac 
                   
               
               
                   
                 ccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc 
                   
               
               
                   
                 tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcg 
                   
               
               
                   
                 aggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagc 
                   
               
               
                   
                 caggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgag 
                   
               
               
                   
                 cagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc 
                   
               
               
                   
                 ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaac 
                   
               
               
                   
                 cggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 25 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 qvqlvqsggqmkkpgesmriscrasgyefi  wirlapgkrpewmg   
                 SEQ ID 
               
               
                   
                    rvtmtrdvysdtaflelsltvddtavyfctr   
                 NO: 193 
               
               
                   
                 wgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgal 
                   
               
               
                   
                 tsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc 
                   
               
               
                   
                 dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfn 
                   
               
               
                   
                 wyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpa 
                   
               
               
                   
                 piektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavewesngq 
                   
               
               
                   
                 pennykttppvldsdgsfflvskftvdksrwqqgnvfscsvlhealhshytqkslsls 
                   
               
               
                   
                 pg 
                   
               
               
                   
               
               
                 Light chain A 
                 eivitqspgftslspgetaiisc  wyqqrpgqaprlviy  gipdrf 
                 SEQ ID 
               
               
                   
                 sgsrwgpdynltisnlesgdfgvyyc  fgqgtkvqvdikrtvaapsvfifpps 
                 NO: 194 
               
               
                   
                 deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst 
                   
               
               
                   
                 ltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgr 
                 SEQ ID 
               
               
                   
                 itgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartg 
                 NO: 195 
               
               
                   
                 kyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvqlvesgggvvqpg 
                   
               
               
                   
                 tslrlscaasqfrfdgygmhwvrqapgkglewvasishdgikkyhaekvw 
                   
               
               
                   
                 grftisrdnskntlylqmnslrpedtalyycakdlredeceewwsdyydfgk 
                   
               
               
                   
                 qlpcaksrgglvgiadnwgqgtmvtvssdkthtastkgpsvfplapssksts 
                   
               
               
                   
                 ggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvp 
                   
               
               
                   
                 ssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsv 
                   
               
               
                   
                 flfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktk 
                   
               
               
                   
                 preeqynstyrvvsyvtvlhqdwlngkeykckvsnkalpapiektiskakg 
                   
               
               
                   
                 qprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpenny 
                   
               
               
                   
                 kttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhshytqkslsls 
                   
               
               
                   
                 pg 
                   
               
               
                   
               
               
                 Light chain B 
                 qsvltqppsvsaapgqkvtiscsgntsnignnfvswyqqrpgrapqlliyetdkrps 
                 SEQ ID 
               
               
                   
                 gipdrfsasksgtsgtlaitglqtgdeadyycatwaaslssarvfgtgtkvivldkthta 
                 NO: 196 
               
               
                   
                 seltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgip 
                   
               
               
                   
                 drfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtva 
                   
               
               
                   
                 apsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd 
                   
               
               
                   
                 skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 25 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgc 
                 SEQ ID 
               
               
                   
                 ggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatca 
                 NO: 197 
               
               
                   
                 gactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcgg 
                   
               
               
                   
                 agccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgtgt 
                   
               
               
                   
                 acagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgtgt 
                   
               
               
                   
                 acttctgcacccggggcaagaactgcgactacaactgggacttcgagcactggggca 
                   
               
               
                   
                 gaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcgtgttccctc 
                   
               
               
                   
                 tggcccctagcagcaagagcacatctggcggaacagccgccctgggctgcctcgtg 
                   
               
               
                   
                 aaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctgaccagcg 
                   
               
               
                   
                 gcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctgagcagcgt 
                   
               
               
                   
                 cgtgacagtgcccagcagctctctgggcacccagacctacatctgcaacgtgaacca 
                   
               
               
                   
                 caagcccagcaacaccaaggtggacaagaaggtggaacccaagagctgcgacaag 
                   
               
               
                   
                 acccacacctgtcccccttgtcctgcccccgaactgctgggaggcccttccgtgttcct 
                   
               
               
                   
                 gttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgacct 
                   
               
               
                   
                 gcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttcaattggtacgtgga 
                   
               
               
                   
                 cggcgtggaagtgcacaacgccaagaccaagccaagagaggaacagtacaacagc 
                   
               
               
                   
                 acctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaa 
                   
               
               
                   
                 gagtacaagtgcaaggtgtccaacaaggccctgcctgcccccatcgagaaaaccatc 
                   
               
               
                   
                 agcaaggccaagggccagccccgcgaaccccaggtgtgcacactgcccccaagca 
                   
               
               
                   
                 gggacgagctgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacc 
                   
               
               
                   
                 cctccgatatcgccgtggaatgggagagcaacggccagcccgagaacaactacaag 
                   
               
               
                   
                 accaccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgacagt 
                   
               
               
                   
                 ggacaagtcccggtggcagcagggcaacgtgttcagctgctccgtgctgcatgaggc 
                   
               
               
                   
                 tctgcacagccactacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain A 
                 Gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacagc 
                 SEQ ID 
               
               
                   
                 catcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagaggc 
                 NO: 198 
               
               
                   
                 ctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccggaatc 
                   
               
               
                   
                 cccgatagattcagcggctccagatggggccctgactacaacctgaccatcagcaac 
                   
               
               
                   
                 ctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcggccagg 
                   
               
               
                   
                 gcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtgttcatctt 
                   
               
               
                   
                 cccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaa 
                   
               
               
                   
                 caacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcaga 
                   
               
               
                   
                 gcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctaca 
                   
               
               
                   
                 gcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtac 
                   
               
               
                   
                 gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccg 
                   
               
               
                   
                 gggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgc 
                 SEQ ID 
               
               
                   
                 ctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggcag 
                 NO: 199 
               
               
                   
                 cctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagggct 
                   
               
               
                   
                 ggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaatac 
                   
               
               
                   
                 caagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggatattact 
                   
               
               
                   
                 tctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggcgagga 
                   
               
               
                   
                 atattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaacccatac 
                   
               
               
                   
                 ccaggtgcagttggtggagtctgggggaggcgtggtccagcctgggacgtccctga 
                   
               
               
                   
                 gactctcctgtgcagcctctcaattcaggtttgatggttatggcatgcactgggtccgcc 
                   
               
               
                   
                 aggccccaggcaaggggctggagtgggtggcatctatatcacatgatggaattaaaa 
                   
               
               
                   
                 agtatcacgcagaaaaagtgtggggccgcttcaccatctccagagacaattccaagaa 
                   
               
               
                   
                 cacactgtatctacaaatgaacagcctgcgacctgaggacacggctctctactactgtg 
                   
               
               
                   
                 cgaaagatttgcgagaagacgaatgtgaagagtggtggtcggattattacgattttggg 
                   
               
               
                   
                 aaacaactcccttgcgcaaagtcacgcggcggcttggttggaattgctgataactggg 
                   
               
               
                   
                 gccaagggacaatggtcaccgtctcttcagataagacccacaccgcttccaccaagg 
                   
               
               
                   
                 gcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcgg 
                   
               
               
                   
                 ccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactc 
                   
               
               
                   
                 aggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggact 
                   
               
               
                   
                 ctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagaccta 
                   
               
               
                   
                 catctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagc 
                   
               
               
                   
                 ccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggg 
                   
               
               
                   
                 gggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccgg 
                   
               
               
                   
                 acccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaa 
                   
               
               
                   
                 gttcaactggtatgttgacggcgtggaggtgcataatgccaagacaaagccgcggga 
                   
               
               
                   
                 ggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccagga 
                   
               
               
                   
                 ctggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccc 
                   
               
               
                   
                 catcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtaca 
                   
               
               
                   
                 ccctgcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctgg 
                   
               
               
                   
                 taaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccg 
                   
               
               
                   
                 gagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctcta 
                   
               
               
                   
                 ctcaaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctc 
                   
               
               
                   
                 cgtgctgcatgaggctctgcacagccactacacgcagaagagcctctccctgtctccg 
                   
               
               
                   
                 ggt 
                   
               
               
                   
               
               
                 Light chain B 
                 cagtctgtgctgacgcagccgccctcagtgtctgcggccccaggacagaagg 
                 SEQ ID 
               
               
                   
                 tcaccatctcctgctctggaaacacctccaacattggcaataattttgtgtcctgg 
                 NO: 200 
               
               
                   
                 tatcaacagcgccccggcagagccccccaactcctcatttatgaaactgacaa 
                   
               
               
                   
                 gcgaccctcagggattcctgaccgattctctgcttccaagtctggtacgtcagg 
                   
               
               
                   
                 caccctggccatcaccgggctgcagactggggacgaggccgattattactgc 
                   
               
               
                   
                 gccacatgggctgccagcctgagttccgcgcgtgtcttcggaactgggacca 
                   
               
               
                   
                 aggtcatcgtcctggacaaaacccataccgcatccgaactgactcaggaccct 
                   
               
               
                   
                 gccgtctctgtggcactgaagcagactgtgactattacttgccgaggcgactca 
                   
               
               
                   
                 ctgcggagccactacgcttcctggtatcagaagaaacccggccaggcacctg 
                   
               
               
                   
                 tgctgctgttctacggaaagaacaataggccatctggcatccccgaccgcttttc 
                   
               
               
                   
                 tggcagtgcatcagggaaccgagccagtctgaccattaccggcgcccaggct 
                   
               
               
                   
                 gaggacgaagccgattactattgcagctcccgggataagagcggctccagac 
                   
               
               
                   
                 tgagcgtgttcggaggaggaactaaactgaccgtcctcgataagacccatacc 
                   
               
               
                   
                 cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagct 
                   
               
               
                   
                 gaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcg 
                   
               
               
                   
                 aggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagc 
                   
               
               
                   
                 caggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgag 
                   
               
               
                   
                 cagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc 
                   
               
               
                   
                 ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaac 
                   
               
               
                   
                 cggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 26 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqts  lfwfrqapgrglewvgw   
                 SEQ ID 
               
               
                   
                    nfgggfrdrvtltrdvyreiaymdirglkpddtavyycar   
                 NO: 201 
               
               
                   
                 wgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsga 
                   
               
               
                   
                 ltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc 
                   
               
               
                   
                 dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfn 
                   
               
               
                   
                 wyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpa 
                   
               
               
                   
                 piektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavewesngq 
                   
               
               
                   
                 pennykttppvldsdgsfflvskftvdksrwqqgnvfscsvlhealhshytqkslsls 
                   
               
               
                   
                 pg 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsysigdrvtincqts  lhwyqhkpgrapkllihhtssvedg 
                 SEQ ID 
               
               
                   
                 vpsrfsgsgf  fnltisdlqaddiatyyc  grgsrlhikrtvaapsvfifppsd 
                 NO: 202 
               
               
                   
                 eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl 
                   
               
               
                   
                 tlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgr 
                 SEQ ID 
               
               
                   
                 itgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartg 
                 NO: 203 
               
               
                   
                 kyydfwsgyppgeeyfqdwgqgtlvivss dkthtqvqlvesgggvvqpg   
                   
               
               
                   
                 
                   tslrlscaasqfrfdgygmhwvrqapgkglewvasishdgikkyhaekvw 
                 
                   
               
               
                   
                 
                   grftisrdnskntlylqmnslrpedtalyycakdlredeceewwsdyydfgk 
                 
                   
               
               
                   
                 
                   qlpcaksrgglvgiadnwgqgtmvtvssdkthtastkgpsvfplapssksts 
                 
                   
               
               
                   
                 
                   ggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvp 
                 
                   
               
               
                   
                 
                   ssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsv 
                 
                   
               
               
                   
                 
                   flfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktk 
                 
                   
               
               
                   
                 
                   preeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakg 
                 
                   
               
               
                   
                 
                   gprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpenny 
                 
                   
               
               
                   
                 
                   kttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhshytqkslsls 
                 
                   
               
               
                   
                 
                   pg 
                 
                   
               
               
                   
               
               
                 Light chain B 
                 qsvltqppsysaapgqkvtiscsgntsnignnfvswyqqrpgrapqlliyetdkrps 
                 SEQ ID 
               
               
                   
                 gipdrfsasksgtsgtlaitglqtgdeadyycatwaaslssarvfgtgtkvivldkthta 
                 NO: 204 
               
               
                   
                 seltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgip 
                   
               
               
                   
                 drfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtva 
                   
               
               
                   
                 apsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd 
                   
               
               
                   
                 skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 26 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcg 
                 SEQ ID 
               
               
                   
                 ggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccggc 
                 NO: 205 
               
               
                   
                 aggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggcgcc 
                   
               
               
                   
                 gtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgc 
                   
               
               
                   
                 gagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactac 
                   
               
               
                   
                 tgcgccagagacagaagctacggcgacagcagctgggctctggatgcttggggcca 
                   
               
               
                   
                 gggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtgttccctctg 
                   
               
               
                   
                 gcccctagcagcaagagcacatctggcggaacagccgccctgggctgcctcgtgaa 
                   
               
               
                   
                 ggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctgaccagcggc 
                   
               
               
                   
                 gtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctgagcagcgtcg 
                   
               
               
                   
                 tgacagtgcccagcagctctctgggcacccagacctacatctgcaacgtgaaccaca 
                   
               
               
                   
                 agcccagcaacaccaaggtggacaagaaggtggaacccaagagctgcgacaagac 
                   
               
               
                   
                 ccacacctgtcccccttgtcctgcccccgaactgctgggaggcccttccgtgttcctgtt 
                   
               
               
                   
                 ccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgacctgcg 
                   
               
               
                   
                 tggtggtggatgtgtcccacgaggaccctgaagtgaagttcaattggtacgtggacgg 
                   
               
               
                   
                 cgtggaagtgcacaacgccaagaccaagccaagagaggaacagtacaacagcacc 
                   
               
               
                   
                 taccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaagag 
                   
               
               
                   
                 tacaagtgcaaggtgtccaacaaggccctgcctgcccccatcgagaaaaccatcagc 
                   
               
               
                   
                 aaggccaagggccagccccgcgaaccccaggtgtgcacactgcccccaagcagg 
                   
               
               
                   
                 gacgagctgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccct 
                   
               
               
                   
                 ccgatatcgccgtggaatgggagagcaacggccagcccgagaacaactacaagac 
                   
               
               
                   
                 caccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgacagtg 
                   
               
               
                   
                 gacaagtcccggtggcagcagggcaacgtgttcagctgctccgtgctgcatgaggct 
                   
               
               
                   
                 ctgcacagccactacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagtg 
                 SEQ ID 
               
               
                   
                 accatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagcac 
                 NO: 206 
               
               
                   
                 aagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagatgg 
                   
               
               
                   
                 cgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcagc 
                   
               
               
                   
                 gatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcag 
                   
               
               
                   
                 aggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcatcttccca 
                   
               
               
                   
                 cctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact 
                   
               
               
                   
                 tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcgg 
                   
               
               
                   
                 caacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg 
                   
               
               
                   
                 agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctg 
                   
               
               
                   
                 cgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcg 
                   
               
               
                   
                 agtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgc 
                 SEQ ID 
               
               
                   
                 ctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggcag 
                 NO: 207 
               
               
                   
                 cctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagggct 
                   
               
               
                   
                 ggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaatac 
                   
               
               
                   
                 caagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggatattact 
                   
               
               
                   
                 tctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggcgagga 
                   
               
               
                   
                 atattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaacccatac 
                   
               
               
                   
                 ccaggtgcagttggtggagtctgggggaggcgtggtccagcctgggacgtccctga 
                   
               
               
                   
                 gactctcctgtgcagcctctcaattcaggtttgatggttatggcatgcactgggtccgcc 
                   
               
               
                   
                 aggccccaggcaaggggctggagtgggtggcatctatatcacatgatggaattaaaa 
                   
               
               
                   
                 agtatcacgcagaaaaagtgtggggccgcttcaccatctccagagacaattccaagaa 
                   
               
               
                   
                 cacactgtatctacaaatgaacagcctgcgacctgaggacacggctctctactactgtg 
                   
               
               
                   
                 cgaaagatttgcgagaagacgaatgtgaagagtggtggtcggattattacgattttggg 
                   
               
               
                   
                 aaacaactcccttgcgcaaagtcacgcggcggcttggttggaattgctgataactggg 
                   
               
               
                   
                 gccaagggacaatggtcaccgtctcttcagataagacccacaccgcttccaccaagg 
                   
               
               
                   
                 gcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcgg 
                   
               
               
                   
                 ccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactc 
                   
               
               
                   
                 aggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggact 
                   
               
               
                   
                 ctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagaccta 
                   
               
               
                   
                 catctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagc 
                   
               
               
                   
                 ccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggg 
                   
               
               
                   
                 gggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccgg 
                   
               
               
                   
                 acccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaa 
                   
               
               
                   
                 gttcaactggtatgttgacggcgtggaggtgcataatgccaagacaaagccgcggga 
                   
               
               
                   
                 ggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccagga 
                   
               
               
                   
                 ctggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccc 
                   
               
               
                   
                 catcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtaca 
                   
               
               
                   
                 ccctgcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctgg 
                   
               
               
                   
                 taaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccg 
                   
               
               
                   
                 gagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctcta 
                   
               
               
                   
                 ctcaaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctc 
                   
               
               
                   
                 cgtgctgcatgaggctctgcacagccactacacgcagaagagcctctccctgtctccg 
                   
               
               
                   
                 ggt 
                   
               
               
                   
               
               
                 Light chain B 
                 cagtctgtgctgacgcagccgccctcagtgtctgcggccccaggacagaaggtcacc 
                 SEQ ID 
               
               
                   
                 atctcctgctctggaaacacctccaacattggcaataattttgtgtcctggtatcaacagc 
                 NO: 208 
               
               
                   
                 gccccggcagagccccccaactcctcatttatgaaactgacaagcgaccctcaggga 
                   
               
               
                   
                 ttcctgaccgattctctgcttccaagtctggtacgtcaggcaccctggccatcaccggg 
                   
               
               
                   
                 ctgcagactggggacgaggccgattattactgcgccacatgggctgccagcctgagtt 
                   
               
               
                   
                 ccgcgcgtgtcttcggaactgggaccaaggtcatcgtcctggacaaaacccataccg 
                   
               
               
                   
                 catccgaactgactcaggaccctgccgtctctgtggcactgaagcagactgtgactatt 
                   
               
               
                   
                 acttgccgaggcgactcactgcggagccactacgcttcctggtatcagaagaaaccc 
                   
               
               
                   
                 ggccaggcacctgtgctgctgttctacggaaagaacaataggccatctggcatccccg 
                   
               
               
                   
                 accgcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggcgccca 
                   
               
               
                   
                 ggctgaggacgaagccgattactattgcagctcccgggataagagcggctccagact 
                   
               
               
                   
                 gagcgtgttcggaggaggaactaaactgaccgtcctcgataagacccatacccgtac 
                   
               
               
                   
                 ggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccgg 
                   
               
               
                   
                 cacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcag 
                   
               
               
                   
                 tggaaggtggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgag 
                   
               
               
                   
                 caggacagcaaggactccacctacagcctgagcagcaccctgacactgagcaaggc 
                   
               
               
                   
                 cgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtcta 
                   
               
               
                   
                 gccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 27 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqts  lfwfrqapgrglewvgw   
                 SEQ ID 
               
               
                   
                    nfgggfrdrvtltrdvyreiaymdirglkpddtavyycar   
                 NO: 209 
               
               
                   
                 wgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsga 
                   
               
               
                   
                 ltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc 
                   
               
               
                   
                 dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcwvdvshedpevkfn 
                   
               
               
                   
                 wyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpa 
                   
               
               
                   
                 piektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavewesngq 
                   
               
               
                   
                 pennykttppvldsdgsfflvskftvdksrwqqgnvfscsvlhealhshytqkslsls 
                   
               
               
                   
                 pg 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg 
                 SEQ ID 
               
               
                   
                 vpsrfsgsgfhtsfqltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifppsd 
                 NO: 210 
               
               
                   
                 eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl 
                   
               
               
                   
                 tlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvg 
                 SEQ ID 
               
               
                   
                 ritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartg 
                 NO: 211 
               
               
                   
                 kyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevrkpgt 
                   
               
               
                   
                 svkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkviverfk 
                   
               
               
                   
                 akvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddgaln 
                   
               
               
                   
                 wavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskstsggta 
                   
               
               
                   
                 algclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpsssl 
                   
               
               
                   
                 gtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfp 
                   
               
               
                   
                 pkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpre 
                   
               
               
                   
                 eqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqpr 
                   
               
               
                   
                 epqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpennyktt 
                   
               
               
                   
                 ppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhshytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr 
                 SEQ ID 
               
               
                   
                 asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkt 
                 NO: 212 
               
               
                   
                 htaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygkrnnrps 
                   
               
               
                   
                 gipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtr 
                   
               
               
                   
                 tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt 
                   
               
               
                   
                 eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 27 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 NO: 213 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg 
                   
               
               
                   
                 ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg 
                   
               
               
                   
                 cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg 
                   
               
               
                   
                 accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag 
                   
               
               
                   
                 ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc 
                   
               
               
                   
                 cttccgtgacctgttccccccaaagcccaaggacaccctgatgatcagccggaccc 
                   
               
               
                   
                 ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttc 
                   
               
               
                   
                 aattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagag 
                   
               
               
                   
                 gaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccagga 
                   
               
               
                   
                 ctggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcc 
                   
               
               
                   
                 cccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtg 
                   
               
               
                   
                 tgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagct 
                   
               
               
                   
                 gtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggc 
                   
               
               
                   
                 cagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt 
                   
               
               
                   
                 cttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgtt 
                   
               
               
                   
                 cagctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctga 
                   
               
               
                   
                 gcctgagccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt 
                 SEQ ID 
               
               
                   
                 gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 
                 NO: 214 
               
               
                   
                 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga 
                   
               
               
                   
                 tggcgtgcccagcagattttccggcagcggcttccacaccagcttccagctgaccat 
                   
               
               
                   
                 cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc 
                   
               
               
                   
                 ggcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcat 
                   
               
               
                   
                 cttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct 
                   
               
               
                   
                 gaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg 
                   
               
               
                   
                 cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccac 
                   
               
               
                   
                 ctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag 
                   
               
               
                   
                 gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt 
                   
               
               
                   
                 caaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 NO: 215 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc 
                   
               
               
                   
                 gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa 
                   
               
               
                   
                 cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca 
                   
               
               
                   
                 cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc 
                   
               
               
                   
                 actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca 
                   
               
               
                   
                 cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac 
                   
               
               
                   
                 tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg 
                   
               
               
                   
                 ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc 
                   
               
               
                   
                 cctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagca 
                   
               
               
                   
                 acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac 
                   
               
               
                   
                 accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc 
                   
               
               
                   
                 tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt 
                   
               
               
                   
                 gacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggct 
                   
               
               
                   
                 gtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagc 
                   
               
               
                   
                 agcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaa 
                   
               
               
                   
                 ggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtg 
                   
               
               
                   
                 cccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaa 
                   
               
               
                   
                 ggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtga 
                   
               
               
                   
                 gccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcata 
                   
               
               
                   
                 atgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtca 
                   
               
               
                   
                 gcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaag 
                   
               
               
                   
                 gtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagg 
                   
               
               
                   
                 gcagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacc 
                   
               
               
                   
                 aagaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgcc 
                   
               
               
                   
                 gtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctccc 
                   
               
               
                   
                 gtgctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagca 
                   
               
               
                   
                 ggtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcc 
                   
               
               
                   
                 actacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg 
                 SEQ ID 
               
               
                   
                 ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                 NO: 216 
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc 
                   
               
               
                   
                 cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg 
                   
               
               
                   
                 tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc 
                   
               
               
                   
                 aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc 
                   
               
               
                   
                 actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc 
                   
               
               
                   
                 ttcctggtatcagaagaaacccggccaggcacctgtgctgctgactacggaaagaa 
                   
               
               
                   
                 caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc 
                   
               
               
                   
                 cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc 
                   
               
               
                   
                 ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc 
                   
               
               
                   
                 gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac 
                   
               
               
                   
                 ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact 
                   
               
               
                   
                 tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg 
                   
               
               
                   
                 gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc 
                   
               
               
                   
                 tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc 
                   
               
               
                   
                 ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg 
                   
               
               
                   
                 ggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 28 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqts  lfwfrqapgrglewvgw   
                 SEQ ID 
               
               
                   
                    nfgggfrdrvtltrdvyreiaymdirglkpddtavyycar   
                 NO: 217 
               
               
                   
                    wgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn 
                   
               
               
                   
                 sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve 
                   
               
               
                   
                 pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp 
                   
               
               
                   
                 evkfnwyvdgvevhnaktkpreegynstyrvvsvltvlhqdwlngkeykckvs 
                   
               
               
                   
                 nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhsh 
                   
               
               
                   
                 ytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvee 
                 SEQ ID 
               
               
                   
                 gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifp 
                 NO: 218 
               
               
                   
                 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Evrlvesggglvkpggsill csasgfdfdnawmtwvrqppgkglewv 
                 SEQ ID 
               
               
                   
                 gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfca 
                 NO: 219 
               
               
                   
                 rtgkyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevr 
                   
               
               
                   
                 kpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkv 
                   
               
               
                   
                 iverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalyd 
                   
               
               
                   
                 ddgalnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapss 
                   
               
               
                   
                 kstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss 
                   
               
               
                   
                 vvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapell 
                   
               
               
                   
                 ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgve 
                   
               
               
                   
                 vhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapie 
                   
               
               
                   
                 ktiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewes 
                   
               
               
                   
                 ngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhs 
                   
               
               
                   
                 hytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas 
                 SEQ ID 
               
               
                   
                 srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik 
                 NO: 220 
               
               
                   
                 dkthtaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygkn 
                   
               
               
                   
                 nrpsgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvl 
                   
               
               
                   
                 dkthtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgn 
                   
               
               
                   
                 sqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 28 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 221 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg 
                   
               
               
                   
                 ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg 
                   
               
               
                   
                 cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg 
                   
               
               
                   
                 accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag 
                   
               
               
                   
                 ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc 
                   
               
               
                   
                 cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc 
                   
               
               
                   
                 ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttc 
                   
               
               
                   
                 aattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagag 
                   
               
               
                   
                 gaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccagga 
                   
               
               
                   
                 ctggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcc 
                   
               
               
                   
                 cccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtg 
                   
               
               
                   
                 tgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagct 
                   
               
               
                   
                 gtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggc 
                   
               
               
                   
                 cagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt 
                   
               
               
                   
                 cttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgtt 
                   
               
               
                   
                 cagctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctga 
                   
               
               
                   
                 gcctgagccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt 
                 SEQ ID NO: 
               
               
                   
                 gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 
                 222 
               
               
                   
                 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga 
                   
               
               
                   
                 aggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccat 
                   
               
               
                   
                 cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc 
                   
               
               
                   
                 ggcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcat 
                   
               
               
                   
                 cttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct 
                   
               
               
                   
                 gaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg 
                   
               
               
                   
                 cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccac 
                   
               
               
                   
                 ctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag 
                   
               
               
                   
                 gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt 
                   
               
               
                   
                 caaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 223 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc 
                   
               
               
                   
                 gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa 
                   
               
               
                   
                 cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca 
                   
               
               
                   
                 cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc 
                   
               
               
                   
                 actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca 
                   
               
               
                   
                 cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac 
                   
               
               
                   
                 tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg 
                   
               
               
                   
                 ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc 
                   
               
               
                   
                 cctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagca 
                   
               
               
                   
                 acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac 
                   
               
               
                   
                 accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc 
                   
               
               
                   
                 tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt 
                   
               
               
                   
                 gacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggct 
                   
               
               
                   
                 gtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagc 
                   
               
               
                   
                 agcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaa 
                   
               
               
                   
                 ggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtg 
                   
               
               
                   
                 cccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaa 
                   
               
               
                   
                 ggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtga 
                   
               
               
                   
                 gccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcata 
                   
               
               
                   
                 atgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtca 
                   
               
               
                   
                 gcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaag 
                   
               
               
                   
                 gtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagg 
                   
               
               
                   
                 gcagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacc 
                   
               
               
                   
                 aagaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgcc 
                   
               
               
                   
                 gtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctccc 
                   
               
               
                   
                 gtgctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagca 
                   
               
               
                   
                 ggtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcc 
                   
               
               
                   
                 actacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg 
                 SEQ ID NO: 
               
               
                   
                 ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                 224 
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc 
                   
               
               
                   
                 cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg 
                   
               
               
                   
                 tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc 
                   
               
               
                   
                 aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc 
                   
               
               
                   
                 actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc 
                   
               
               
                   
                 ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa 
                   
               
               
                   
                 caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc 
                   
               
               
                   
                 cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc 
                   
               
               
                   
                 ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc 
                   
               
               
                   
                 gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac 
                   
               
               
                   
                 ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact 
                   
               
               
                   
                 tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg 
                   
               
               
                   
                 gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc 
                   
               
               
                   
                 tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc 
                   
               
               
                   
                 ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg 
                   
               
               
                   
                 ggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 29 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqts  lfwfrqapgrglewvgw   
                 SEQ ID NO: 
               
               
                   
                    nfgggfrdrvtltrdvyreiaymdirglkpddtavyycar   
                 225 
               
               
                   
                    wgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn 
                   
               
               
                   
                 sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve 
                   
               
               
                   
                 pkscdkthtcppcpapellggpsvflfppkpkdtimisrtpevtcvvvdvshedp 
                   
               
               
                   
                 evkfnwyvdgvevhnaktkpreegynstyrvvsvltvlhqdwlngkeykckvs 
                   
               
               
                   
                 nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave 
                   
               
               
                   
                 wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhsh 
                   
               
               
                   
                 ytqkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                 SEQ ID NO: 
               
               
                   
                 avpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 
                 226 
               
               
                   
                 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl 
                   
               
               
                   
                 sstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv 
                 SEQ ID NO: 
               
               
                   
                 gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfca 
                 227 
               
               
                   
                 rtgkyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevr 
                   
               
               
                   
                 kpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkv 
                   
               
               
                   
                 iverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalyd 
                   
               
               
                   
                 ddgalnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapss 
                   
               
               
                   
                 kstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss 
                   
               
               
                   
                 vvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapell 
                   
               
               
                   
                 ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgve 
                   
               
               
                   
                 vhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapie 
                   
               
               
                   
                 ktiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewes 
                   
               
               
                   
                 ngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhs 
                   
               
               
                   
                 hytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas 
                 SEQ ID NO: 
               
               
                   
                 srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik 
                 228 
               
               
                   
                 dkthtaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygkn 
                   
               
               
                   
                 nrpsgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvl 
                   
               
               
                   
                 dkthtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgn 
                   
               
               
                   
                 sqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 29 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 229 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg 
                   
               
               
                   
                 ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg 
                   
               
               
                   
                 cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg 
                   
               
               
                   
                 accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag 
                   
               
               
                   
                 ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc 
                   
               
               
                   
                 cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc 
                   
               
               
                   
                 ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca 
                   
               
               
                   
                 attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg 
                   
               
               
                   
                 aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac 
                   
               
               
                   
                 tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc 
                   
               
               
                   
                 catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg 
                   
               
               
                   
                 cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt 
                   
               
               
                   
                 gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct 
                   
               
               
                   
                 tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctgag 
                   
               
               
                   
                 cctgagccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt 
                 SEQ ID NO: 
               
               
                   
                 gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 
                 230 
               
               
                   
                 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga 
                   
               
               
                   
                 tgccgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatc 
                   
               
               
                   
                 agcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcg 
                   
               
               
                   
                 gcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcatc 
                   
               
               
                   
                 ttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctg 
                   
               
               
                   
                 aacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgc 
                   
               
               
                   
                 agagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacct 
                   
               
               
                   
                 acagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggt 
                   
               
               
                   
                 gtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttca 
                   
               
               
                   
                 accggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgactgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 231 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc 
                   
               
               
                   
                 gaggaatattacaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa 
                   
               
               
                   
                 cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca 
                   
               
               
                   
                 cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc 
                   
               
               
                   
                 actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca 
                   
               
               
                   
                 cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac 
                   
               
               
                   
                 tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg 
                   
               
               
                   
                 ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc 
                   
               
               
                   
                 cctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagca 
                   
               
               
                   
                 acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac 
                   
               
               
                   
                 accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc 
                   
               
               
                   
                 tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt 
                   
               
               
                   
                 gacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctg 
                   
               
               
                   
                 tcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagca 
                   
               
               
                   
                 gcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaag 
                   
               
               
                   
                 gtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgc 
                   
               
               
                   
                 ccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaag 
                   
               
               
                   
                 gacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgag 
                   
               
               
                   
                 ccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataa 
                   
               
               
                   
                 tgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagc 
                   
               
               
                   
                 gtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggt 
                   
               
               
                   
                 ctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg 
                   
               
               
                   
                 cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca 
                   
               
               
                   
                 agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt 
                   
               
               
                   
                 ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt 
                   
               
               
                   
                 gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag 
                   
               
               
                   
                 gtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcca 
                   
               
               
                   
                 ctacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg 
                 SEQ ID NO: 
               
               
                   
                 ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                 301 
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc 
                   
               
               
                   
                 cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg 
                   
               
               
                   
                 tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc 
                   
               
               
                   
                 aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc 
                   
               
               
                   
                 actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc 
                   
               
               
                   
                 ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa 
                   
               
               
                   
                 caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc 
                   
               
               
                   
                 cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc 
                   
               
               
                   
                 ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc 
                   
               
               
                   
                 gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac 
                   
               
               
                   
                 ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact 
                   
               
               
                   
                 tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg 
                   
               
               
                   
                 gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc 
                   
               
               
                   
                 tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc 
                   
               
               
                   
                 ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggg 
                   
               
               
                   
                 gcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 30 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqts  lfwfrqapgrglewvgw   
                 SEQ ID NO: 
               
               
                   
                    nfgggfrdrvtltrdvyreiaymdirglkpddtavyycar   
                 232 
               
               
                   
                    wgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns 
                   
               
               
                   
                 galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep 
                   
               
               
                   
                 kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe 
                   
               
               
                   
                 vkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsn 
                   
               
               
                   
                 kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew 
                   
               
               
                   
                 esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhshyt 
                   
               
               
                   
                 qkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvee 
                 SEQ ID NO: 
               
               
                   
                 gvpsrfsgsgfhtsfqltisdlqaddiatyycqvlqffgrgsflhikrtvaapsvfifp 
                 233 
               
               
                   
                 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv 
                 SEQ ID NO: 
               
               
                   
                 gritgpgegwsvdyaesykgrftisrdntkntlylemnnvrtedtgyyfca 
                 234 
               
               
                   
                 rtgkyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevr 
                   
               
               
                   
                 kpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkv 
                   
               
               
                   
                 iverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalyd 
                   
               
               
                   
                 ddgalnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapss 
                   
               
               
                   
                 kstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss 
                   
               
               
                   
                 vvtvpssslgtqtyicnynhkpsntkvdkkvepkscdkthtcppcpapell 
                   
               
               
                   
                 ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyydgve 
                   
               
               
                   
                 vhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapie 
                   
               
               
                   
                 ktiskakgqprepqvytlppcrdeltknqvslwclykgfypsdiavewes 
                   
               
               
                   
                 ngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhs 
                   
               
               
                   
                 hytqkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas 
                 SEQ ID NO: 
               
               
                   
                 srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik 
                 235 
               
               
                   
                 dkthtaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygkn 
                   
               
               
                   
                 nrpsgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvl 
                   
               
               
                   
                 dkthtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgn 
                   
               
               
                   
                 sqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 30 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgactggttccg 
                 236 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg 
                   
               
               
                   
                 ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg 
                   
               
               
                   
                 cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg 
                   
               
               
                   
                 accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag 
                   
               
               
                   
                 ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc 
                   
               
               
                   
                 cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc 
                   
               
               
                   
                 ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca 
                   
               
               
                   
                 attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg 
                   
               
               
                   
                 aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac 
                   
               
               
                   
                 tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc 
                   
               
               
                   
                 catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg 
                   
               
               
                   
                 cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt 
                   
               
               
                   
                 gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct 
                   
               
               
                   
                 tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctgag 
                   
               
               
                   
                 cctgagccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt 
                 SEQ ID NO: 
               
               
                   
                 gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 
                 237 
               
               
                   
                 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga 
                   
               
               
                   
                 aggcgtgcccagcagattttccggcagcggcttccacaccagcttccagctgaccat 
                   
               
               
                   
                 cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc 
                   
               
               
                   
                 ggcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcat 
                   
               
               
                   
                 cttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct 
                   
               
               
                   
                 gaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg 
                   
               
               
                   
                 cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccac 
                   
               
               
                   
                 ctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag 
                   
               
               
                   
                 gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt 
                   
               
               
                   
                 caaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 238 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc 
                   
               
               
                   
                 gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa 
                   
               
               
                   
                 cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca 
                   
               
               
                   
                 cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc 
                   
               
               
                   
                 actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca 
                   
               
               
                   
                 cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac 
                   
               
               
                   
                 tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg 
                   
               
               
                   
                 ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc 
                   
               
               
                   
                 cctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagca 
                   
               
               
                   
                 acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac 
                   
               
               
                   
                 accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc 
                   
               
               
                   
                 tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt 
                   
               
               
                   
                 gacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctg 
                   
               
               
                   
                 tcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagca 
                   
               
               
                   
                 gcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaag 
                   
               
               
                   
                 gtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgc 
                   
               
               
                   
                 ccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaag 
                   
               
               
                   
                 gacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgag 
                   
               
               
                   
                 ccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataa 
                   
               
               
                   
                 tgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagc 
                   
               
               
                   
                 gtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggt 
                   
               
               
                   
                 ctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg 
                   
               
               
                   
                 cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca 
                   
               
               
                   
                 agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt 
                   
               
               
                   
                 ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt 
                   
               
               
                   
                 gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag 
                   
               
               
                   
                 gtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcca 
                   
               
               
                   
                 ctacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 Gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg 
                 SEQ ID NO: 
               
               
                   
                 ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                 239 
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc 
                   
               
               
                   
                 cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg 
                   
               
               
                   
                 tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc 
                   
               
               
                   
                 aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc 
                   
               
               
                   
                 actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc 
                   
               
               
                   
                 ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa 
                   
               
               
                   
                 caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc 
                   
               
               
                   
                 cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc 
                   
               
               
                   
                 ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc 
                   
               
               
                   
                 gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac 
                   
               
               
                   
                 ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact 
                   
               
               
                   
                 tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg 
                   
               
               
                   
                 gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc 
                   
               
               
                   
                 tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc 
                   
               
               
                   
                 ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggg 
                   
               
               
                   
                 gcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 31 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqts  lfwfrqapgrglewvgw   
                 SEQ ID NO: 
               
               
                   
                    nfgggfrdrvtltrdvyreiaymdirglkpddtavyycar   
                 240 
               
               
                   
                    wgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns 
                   
               
               
                   
                 galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep 
                   
               
               
                   
                 kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe 
                   
               
               
                   
                 vkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsn 
                   
               
               
                   
                 kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew 
                   
               
               
                   
                 esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhshyt 
                   
               
               
                   
                 qkslslspg 
                   
               
               
                   
               
               
                 Light chain A 
                 Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                 SEQ ID NO: 
               
               
                   
                 avpsrfsgsgfhtsfqltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 
                 241 
               
               
                   
                 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl 
                   
               
               
                   
                 sstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv 
                 SEQ ID NO: 
               
               
                   
                 gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 
                 242 
               
               
                   
                 tgkyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevrk 
                   
               
               
                   
                 pgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkviv 
                   
               
               
                   
                 erfkakvtidwdrstntaylqlsgitsgdtavyycakgskhrlrdyalyddd 
                   
               
               
                   
                 galnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskst 
                   
               
               
                   
                 sggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvt 
                   
               
               
                   
                 vpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellgg 
                   
               
               
                   
                 psvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhn 
                   
               
               
                   
                 aktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektis 
                   
               
               
                   
                 kakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngq 
                   
               
               
                   
                 pennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhshyt 
                   
               
               
                   
                 qkslslspg 
                   
               
               
                   
               
               
                 Light chain B 
                 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass 
                 SEQ ID NO: 
               
               
                   
                 rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikd 
                 243 
               
               
                   
                 kthtaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnr 
                   
               
               
                   
                 psgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldk 
                   
               
               
                   
                 thtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq 
                   
               
               
                   
                 esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 31 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc 
                 SEQ ID NO: 
               
               
                   
                 gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 
                 244 
               
               
                   
                 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc 
                   
               
               
                   
                 gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta 
                   
               
               
                   
                 ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg 
                   
               
               
                   
                 tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg 
                   
               
               
                   
                 gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg 
                   
               
               
                   
                 ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg 
                   
               
               
                   
                 cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg 
                   
               
               
                   
                 accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa 
                   
               
               
                   
                 cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag 
                   
               
               
                   
                 ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc 
                   
               
               
                   
                 cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc 
                   
               
               
                   
                 ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttc 
                   
               
               
                   
                 aattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagag 
                   
               
               
                   
                 gaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccagga 
                   
               
               
                   
                 ctggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcc 
                   
               
               
                   
                 cccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtg 
                   
               
               
                   
                 tgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagct 
                   
               
               
                   
                 gtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggc 
                   
               
               
                   
                 cagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt 
                   
               
               
                   
                 cttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgtt 
                   
               
               
                   
                 cagctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctga 
                   
               
               
                   
                 gcctgagccccggc 
                   
               
               
                   
               
               
                 Light chain A 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt 
                 SEQ ID NO: 
               
               
                   
                 gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 
                 245 
               
               
                   
                 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga 
                   
               
               
                   
                 tgccgtgcccagcagattttccggcagcggcttccacaccagcttccagctgaccat 
                   
               
               
                   
                 cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc 
                   
               
               
                   
                 ggcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcat 
                   
               
               
                   
                 cttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct 
                   
               
               
                   
                 gaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg 
                   
               
               
                   
                 cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccac 
                   
               
               
                   
                 ctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag 
                   
               
               
                   
                 gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt 
                   
               
               
                   
                 caaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg 
                 SEQ ID NO: 
               
               
                   
                 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 
                 246 
               
               
                   
                 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg 
                   
               
               
                   
                 gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca 
                   
               
               
                   
                 ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat 
                   
               
               
                   
                 attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc 
                   
               
               
                   
                 gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa 
                   
               
               
                   
                 cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca 
                   
               
               
                   
                 cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc 
                   
               
               
                   
                 actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca 
                   
               
               
                   
                 cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac 
                   
               
               
                   
                 tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg 
                   
               
               
                   
                 ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc 
                   
               
               
                   
                 cctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagca 
                   
               
               
                   
                 acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac 
                   
               
               
                   
                 accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc 
                   
               
               
                   
                 tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt 
                   
               
               
                   
                 gacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggct 
                   
               
               
                   
                 gtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagc 
                   
               
               
                   
                 agcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaa 
                   
               
               
                   
                 ggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtg 
                   
               
               
                   
                 cccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaa 
                   
               
               
                   
                 ggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtga 
                   
               
               
                   
                 gccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcata 
                   
               
               
                   
                 atgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtca 
                   
               
               
                   
                 gcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaag 
                   
               
               
                   
                 gtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagg 
                   
               
               
                   
                 gcagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacc 
                   
               
               
                   
                 aagaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgcc 
                   
               
               
                   
                 gtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctccc 
                   
               
               
                   
                 gtgctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagca 
                   
               
               
                   
                 ggtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcc 
                   
               
               
                   
                 actacacgcagaagagcctctccctgtctccgggt 
                   
               
               
                   
               
               
                 Light chain B 
                 Gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg 
                 SEQ ID NO: 
               
               
                   
                 ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                 247 
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc 
                   
               
               
                   
                 cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg 
                   
               
               
                   
                 tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc 
                   
               
               
                   
                 aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc 
                   
               
               
                   
                 actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc 
                   
               
               
                   
                 ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa 
                   
               
               
                   
                 caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc 
                   
               
               
                   
                 cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc 
                   
               
               
                   
                 ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc 
                   
               
               
                   
                 gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac 
                   
               
               
                   
                 ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact 
                   
               
               
                   
                 tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg 
                   
               
               
                   
                 gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc 
                   
               
               
                   
                 tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc 
                   
               
               
                   
                 ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg 
                   
               
               
                   
                 ggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 32 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq 
                 SEQ ID NO: 
               
               
                   
                 ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswald 
                 302 
               
               
                   
                 awgqgttvvvsaastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsg 
                   
               
               
                   
                 altsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrvesky 
                   
               
               
                   
                 gppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfn 
                   
               
               
                   
                 wyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglps 
                   
               
               
                   
                 siektiskakgqprepqvytlppcqeemtknqvslwclvkgfypsdiavewesn 
                   
               
               
                   
                 gqpennykttppvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqk 
                   
               
               
                   
                 slslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                 SEQ ID NO: 
               
               
                   
                 gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 
                 303 
               
               
                   
                 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysls 
                   
               
               
                   
                 stltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvqlvqsgaevvkpgasvkvsckas  ihwvrqapgqglewig 
                 SEQ ID NO: 
               
               
                   
                 s  nyaqkfqgratltvdtsistaymelsrlrsddtavyyc   
                 304 
               
               
                   
                    wgkgttvtvsssqvqlvesgggvvqpgrslrlscaas   
                   
               
               
                   
                 mhwvrqapgkqlewvaq  yatyyadsvkgrftisrddskntlyl 
                   
               
               
                   
                 qmnslraedtavyyc  wgqgtlvtvssrtastkgpsvfpla 
                   
               
               
                   
                 pcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysls 
                   
               
               
                   
                 svvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflgg 
                   
               
               
                   
                 psvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhn 
                   
               
               
                   
                 aktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektisk 
                   
               
               
                   
                 akgqprepqvctlppsqeemtknqvslscavkgfypsdiavewesngqp 
                   
               
               
                   
                 ennykttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytq 
                   
               
               
                   
                 kslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckss  lswylqkpgqspqsliy   
                 SEQ ID NO: 
               
               
                   
                 snrfsgvpdrfsgsgsgtdftlkisrveaedvgvyyc  ftfgsgtkveikg 
                 305 
               
               
                   
                 qpkaapdiqmtqspsslsasvgdrvtitcqas  lnwyqqkpgkapklliy 
                   
               
               
                   
                 kasnlhtgvpsrfsgsgsgtdftltisslqpediatyyc  fgqgtkleiktk 
                   
               
               
                   
                 gpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq 
                   
               
               
                   
                 esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 32 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcgg 
                 SEQ ID 
               
               
                   
                 gtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccggcag 
                 NO: 306 
               
               
                   
                 gcccctggcagaggactggaatgggtgggatggatcaagccccagtatggcgccgtg 
                   
               
               
                   
                 aacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgcgag 
                   
               
               
                   
                 atcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactactgcg 
                   
               
               
                   
                 ccagagacagaagctacggcgacagcagctgggctctggatgcttggggccagggc 
                   
               
               
                   
                 acaaccgtggtggtgtctgccgcctctacaaagggcccctcggtgttccctctggcccc 
                   
               
               
                   
                 ttgcagcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactac 
                   
               
               
                   
                 tttcccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacac 
                   
               
               
                   
                 ctttccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgc 
                   
               
               
                   
                 ccagcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagca 
                   
               
               
                   
                 acaccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgccc 
                   
               
               
                   
                 agcccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggaca 
                   
               
               
                   
                 ccctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccagga 
                   
               
               
                   
                 agatcccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaa 
                   
               
               
                   
                 gaccaagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgac 
                   
               
               
                   
                 cgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaa 
                   
               
               
                   
                 gggcctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcg 
                   
               
               
                   
                 agcctcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtc 
                   
               
               
                   
                 cctgtggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagca 
                   
               
               
                   
                 acggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggc 
                   
               
               
                   
                 tcattcttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgt 
                   
               
               
                   
                 gttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgt 
                   
               
               
                   
                 ctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 Tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagtg 
                 SEQ ID 
               
               
                   
                 accatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagcaca 
                 NO: 307 
               
               
                   
                 agcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagatggc 
                   
               
               
                   
                 gtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcagcga 
                   
               
               
                   
                 tctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcagagg 
                   
               
               
                   
                 cagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcatcttcccaccta 
                   
               
               
                   
                 gcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctac 
                   
               
               
                   
                 ccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca 
                   
               
               
                   
                 gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagc 
                   
               
               
                   
                 accctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtg 
                   
               
               
                   
                 acccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaag 
                 SEQ ID 
               
               
                   
                 gtgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgcca 
                 NO: 308 
               
               
                   
                 ggcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacac 
                   
               
               
                   
                 caactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcag 
                   
               
               
                   
                 caccgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactg 
                   
               
               
                   
                 cacccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccac 
                   
               
               
                   
                 cgtgacagtgtctagcagccaggtgcagctggtggaatctggcggcggagtggtgca 
                   
               
               
                   
                 gcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaaggc 
                   
               
               
                   
                 ctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggcccagat 
                   
               
               
                   
                 caaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccggt 
                   
               
               
                   
                 tcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctgc 
                   
               
               
                   
                 gggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcccctt 
                   
               
               
                   
                 cgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgccagcacaaa 
                   
               
               
                   
                 gggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagcc 
                   
               
               
                   
                 gccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactc 
                   
               
               
                   
                 tggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctg 
                   
               
               
                   
                 tactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctaca 
                   
               
               
                   
                 cctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatcta 
                   
               
               
                   
                 agtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgtgt 
                   
               
               
                   
                 tcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgac 
                   
               
               
                   
                 ctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtgg 
                   
               
               
                   
                 acggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagc 
                   
               
               
                   
                 acctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaa 
                   
               
               
                   
                 gagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc 
                   
               
               
                   
                 agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagcca 
                   
               
               
                   
                 ggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccc 
                   
               
               
                   
                 agcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagac 
                   
               
               
                   
                 caccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgg 
                   
               
               
                   
                 acaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccc 
                   
               
               
                   
                 tgcacaaccactacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg 
                 NO: 309 
               
               
                   
                 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca 
                   
               
               
                   
                 acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac 
                   
               
               
                   
                 cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg 
                   
               
               
                   
                 cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagcc 
                   
               
               
                   
                 caaggccgcccccgacatccagatgacccagagccccagcagcctgtctgccagcgt 
                   
               
               
                   
                 gggcgacagagtgaccatcacctgtcaggccagccagaacatctacgtgtggctgaa 
                   
               
               
                   
                 ctggtatcagcagaagcccggcaaggcccccaagctgctgatctacaaggccagcaa 
                   
               
               
                   
                 cctgcacaccggcgtgcccagcagattttctggcagcggctccggcaccgacttcacc 
                   
               
               
                   
                 ctgacaatcagctccctgcagcccgaggacattgccacctactactgccagcagggcc 
                   
               
               
                   
                 agacctacccctacacctttggccagggcaccaagctggaaatcaagaccaagggcc 
                   
               
               
                   
                 ccagccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagct 
                   
               
               
                   
                 gaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcc 
                   
               
               
                   
                 aaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagcgt 
                   
               
               
                   
                 gaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgacactga 
                   
               
               
                   
                 gcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggc 
                   
               
               
                   
                 ctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 33 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpqy 
                 SEQ ID 
               
               
                   
                 gavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswaldaw 
                 NO: 310 
               
               
                   
                 gqgttvvvsaastkgp svfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsg 
                   
               
               
                   
                 vhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcp 
                   
               
               
                   
                 pcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgv 
                   
               
               
                   
                 evhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiska 
                   
               
               
                   
                 kgqprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykt 
                   
               
               
                   
                 tppvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg 
                 SEQ ID 
               
               
                   
                 vpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifppsd 
                 NO: 311 
               
               
                   
                 eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl 
                   
               
               
                   
                 skadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgvi 
                 SEQ ID 
               
               
                   
                 wagggtnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysy 
                 NO: 312 
               
               
                   
                 yysmdywgqgttvtvsssqvqlvesgggvvqpgrslrlscaasgftftkaw 
                   
               
               
                   
                 mhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskntlylq 
                   
               
               
                   
                 mnslraedtavyycrgvyyalspfdywgqgtlvtvssrtastkgpsvfplapc 
                   
               
               
                   
                 srstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv 
                   
               
               
                   
                 tvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggpsvf 
                   
               
               
                   
                 lfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnaktkp 
                   
               
               
                   
                 reeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgqpr 
                   
               
               
                   
                 epqvctlppsqeemtknqvslscavkgfypsdiavewesngqpennyktt 
                   
               
               
                   
                 ppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs 
                 SEQ ID 
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp 
                 NO: 313 
               
               
                   
                 kaapdivltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifa 
                   
               
               
                   
                 asnvesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikt 
                   
               
               
                   
                 kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq 
                   
               
               
                   
                 esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 33 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcgg 
                 SEQ ID 
               
               
                   
                 gtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccggcag 
                 NO: 314 
               
               
                   
                 gcccctggcagaggactggaatgggtgggatggatcaagccccagtatggcgccgtg 
                   
               
               
                   
                 aacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgcgag 
                   
               
               
                   
                 atcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactactgcg 
                   
               
               
                   
                 ccagagacagaagctacggcgacagcagctgggctctggatgcttggggccagggc 
                   
               
               
                   
                 acaaccgtggtggtgtctgccgcctctacaaagggcccctcggtgttccctctggcccc 
                   
               
               
                   
                 ttgcagcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactac 
                   
               
               
                   
                 tttcccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacac 
                   
               
               
                   
                 ctttccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgc 
                   
               
               
                   
                 ccagcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagca 
                   
               
               
                   
                 acaccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgccc 
                   
               
               
                   
                 agcccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggaca 
                   
               
               
                   
                 ccctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccagga 
                   
               
               
                   
                 agatcccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaa 
                   
               
               
                   
                 gaccaagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgac 
                   
               
               
                   
                 cgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaa 
                   
               
               
                   
                 gggcctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcg 
                   
               
               
                   
                 agcctcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtc 
                   
               
               
                   
                 cctgtggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagca 
                   
               
               
                   
                 acggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggc 
                   
               
               
                   
                 tcattcttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgt 
                   
               
               
                   
                 gttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgt 
                   
               
               
                   
                 ctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 Tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagtg 
                 SEQ ID 
               
               
                   
                 accatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagcaca 
                 NO: 315 
               
               
                   
                 agcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagatggc 
                   
               
               
                   
                 gtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcagcga 
                   
               
               
                   
                 tctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcagagg 
                   
               
               
                   
                 cagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcatcttcccaccta 
                   
               
               
                   
                 gcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctac 
                   
               
               
                   
                 ccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca 
                   
               
               
                   
                 gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagc 
                   
               
               
                   
                 accctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtg 
                   
               
               
                   
                 acccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagc 
                 SEQ ID 
               
               
                   
                 ctgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcc 
                 NO: 316 
               
               
                   
                 agccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcacc 
                   
               
               
                   
                 aactacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaac 
                   
               
               
                   
                 caggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcg 
                   
               
               
                   
                 ccagagacaagggctacagctactactacagcatggactactggggccagggcacca 
                   
               
               
                   
                 ccgtgaccgtgtcatcctctcaggtgcagctggtggaatctggcggcggagtggtgca 
                   
               
               
                   
                 gcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaaggc 
                   
               
               
                   
                 ctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggcccagat 
                   
               
               
                   
                 caaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccggt 
                   
               
               
                   
                 tcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctgc 
                   
               
               
                   
                 gggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcccctt 
                   
               
               
                   
                 cgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcgaccaag 
                   
               
               
                   
                 ggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagccg 
                   
               
               
                   
                 ccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactct 
                   
               
               
                   
                 ggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctgt 
                   
               
               
                   
                 actctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctaca 
                   
               
               
                   
                 cctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatcta 
                   
               
               
                   
                 agtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgtgt 
                   
               
               
                   
                 tcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgac 
                   
               
               
                   
                 ctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtgg 
                   
               
               
                   
                 acggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagc 
                   
               
               
                   
                 acctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaa 
                   
               
               
                   
                 gagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc 
                   
               
               
                   
                 agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagcca 
                   
               
               
                   
                 ggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccc 
                   
               
               
                   
                 agcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagac 
                   
               
               
                   
                 caccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgg 
                   
               
               
                   
                 acaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccc 
                   
               
               
                   
                 tgcacaaccactacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg 
                 NO: 317 
               
               
                   
                 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca 
                   
               
               
                   
                 acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac 
                   
               
               
                   
                 cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg 
                   
               
               
                   
                 cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagcc 
                   
               
               
                   
                 caaggccgcccccgacatcgtgctgacacagagccctgctagcctggccgtgtctcct 
                   
               
               
                   
                 ggacagagggccaccatcacctgtagagccagcgagagcgtggaatattacgtgacc 
                   
               
               
                   
                 agcctgatgcagtggtatcagcagaagcccggccagccccccaagctgctgattttcg 
                   
               
               
                   
                 ccgccagcaacgtggaaagcggcgtgccagccagattttccggcagcggctctggca 
                   
               
               
                   
                 ccgacttcaccctgaccatcaaccccgtggaagccaacgacgtggccaactactactg 
                   
               
               
                   
                 ccagcagagccggaaggtgccctacacctttggccagggcaccaagctggaaatcaa 
                   
               
               
                   
                 gaccaagggccccagccgtacggtggccgctcccagcgtgttcatcttcccacctagc 
                   
               
               
                   
                 gacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctaccc 
                   
               
               
                   
                 ccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagc 
                   
               
               
                   
                 caggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcac 
                   
               
               
                   
                 cctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgac 
                   
               
               
                   
                 ccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 34 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishe 
                 SEQ ID 
               
               
                   
                 gdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydd 
                 NO: 318 
               
               
                   
                 dgalnwavdvdylsnlefwgqgtavtvssastkgpsvfplapcsrstsestaalgclv 
                   
               
               
                   
                 kdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdh 
                   
               
               
                   
                 kpsntkvdkrveskygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvv 
                   
               
               
                   
                 vdvsqedpevqfnwyvdgvevhnaktkpreeqfnstyrvvsyltvlhqdwlngke 
                   
               
               
                   
                 ykckvsnkglpssiektiskakgqprepqvytlppcqeemtknqvslwclvkgfyp 
                   
               
               
                   
                 sdiavewesngqpennykttppvldsdgsfflyskltvdksrwqegnvfscsvmhe 
                   
               
               
                   
                 alhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr 
                 SEQ ID 
               
               
                   
                 asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikr tva   
                 NO: 319 
               
               
                   
                 
                   apsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds 
                 
                   
               
               
                   
                 
                   kdstyslsstltlskadvekhkvyacevthqglsspvtksfnrgec 
                 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvqlvqsgaevvkpgasvkvsckas  ihwyrqapgqglewigs   
                 SEQ ID 
               
               
                   
                    nyaqkfqgratltvdtsistaymelsrlrsddtavyyc   
                 NO: 320 
               
               
                   
                    wgkgttvtvsssqvqlvesgggvvqpgrslrlscaas  mh 
                   
               
               
                   
                 wvrqapgkqlewvaq  yatyyadsvkgrftisrddskntlylqmn 
                   
               
               
                   
                 slraedtavyyc  wgqgtlvtvssrtastkgpsvfplapcsrst 
                   
               
               
                   
                 sestaalgclykdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvp 
                   
               
               
                   
                 ssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggpsvflfp 
                   
               
               
                   
                 pkpkdtlmisrtpevtcvvvdvsqedpevqfnwyydgvevhnaktkpree 
                   
               
               
                   
                 qfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgqprep 
                   
               
               
                   
                 qvctlppsqeemtknqvslscavkgfypsdiavewesngqpennykttpp 
                   
               
               
                   
                 vldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckss  lswylqkpgqspqsliy   
                 SEQ ID 
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyyc  ftfgsgtkveikgqp 
                 NO: 321 
               
               
                   
                 kaapdiqmtqspsslsasvgdrvtitcqas  lnwyqqkpgkapklliy   
                   
               
               
                   
                 nlhtgvpsrfsgsgsgtdftltisslqpediatyyc  fgqgtkleiktkgpsr 
                   
               
               
                   
                 tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvte 
                   
               
               
                   
                 qdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 34 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaa 
                 SEQ ID 
               
               
                   
                 ggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgc 
                 NO: 322 
               
               
                   
                 agcgtgccaggacagggactgcagtggatgggctggatcagccacgagggcgacaa 
                   
               
               
                   
                 gaaagtgatcgtggaacgglIcaaggccaaagtgaccatcgactgggacagaagcac 
                   
               
               
                   
                 caacaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactact 
                   
               
               
                   
                 gcgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacggc 
                   
               
               
                   
                 gccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggccagg 
                   
               
               
                   
                 gcacagccgtgaccgtgtcatctgcttcgaccaagggcccctcggtgttccctctggcc 
                   
               
               
                   
                 ccttgcagcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggact 
                   
               
               
                   
                 actttcccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcac 
                   
               
               
                   
                 acctttccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagt 
                   
               
               
                   
                 gcccagcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagccca 
                   
               
               
                   
                 gcaacaccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttg 
                   
               
               
                   
                 cccagcccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaagg 
                   
               
               
                   
                 acaccctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtccca 
                   
               
               
                   
                 ggaagatcccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgc 
                   
               
               
                   
                 caagaccaagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgct 
                   
               
               
                   
                 gaccgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaa 
                   
               
               
                   
                 caagggcctgcccagctccatcgagaaaaccatcagcaaggccaagggccagcccc 
                   
               
               
                   
                 gcgagcctcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggt 
                   
               
               
                   
                 gtccctgtggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggaga 
                   
               
               
                   
                 gcaacggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgac 
                   
               
               
                   
                 ggctcattcttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggca 
                   
               
               
                   
                 acgtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtc 
                   
               
               
                   
                 cctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccactccctgatccacggcgaccggaacaactacctg 
                 NO: 323 
               
               
                   
                 gcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggccagca 
                   
               
               
                   
                 gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggacttca 
                   
               
               
                   
                 ccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgcagg 
                   
               
               
                   
                 gcagagagagcccctggacctttggccagggcaccaaggtggacatcaagcgtacg 
                   
               
               
                   
                 gtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggca 
                   
               
               
                   
                 cagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtgg 
                   
               
               
                   
                 aaggtggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcagg 
                   
               
               
                   
                 acagcaaggactccacctacagcctgagcagcaccctgacactgagcaaggccgact 
                   
               
               
                   
                 acgagaagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccg 
                   
               
               
                   
                 tgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaag 
                 SEQ ID 
               
               
                   
                 gtgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgcca 
                 NO: 324 
               
               
                   
                 ggcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacac 
                   
               
               
                   
                 caactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcag 
                   
               
               
                   
                 caccgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactg 
                   
               
               
                   
                 cacccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccac 
                   
               
               
                   
                 cgtgacagtgtctagcagccaggtgcagctggtggaatctggcggcggagtggtgca 
                   
               
               
                   
                 gcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaaggc 
                   
               
               
                   
                 ctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggcccagat 
                   
               
               
                   
                 caaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccggt 
                   
               
               
                   
                 tcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctgc 
                   
               
               
                   
                 gggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcccctt 
                   
               
               
                   
                 cgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgccagcacaaa 
                   
               
               
                   
                 gggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagcc 
                   
               
               
                   
                 gccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactc 
                   
               
               
                   
                 tggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctg 
                   
               
               
                   
                 tactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctaca 
                   
               
               
                   
                 cctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatcta 
                   
               
               
                   
                 agtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgtgt 
                   
               
               
                   
                 tcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgac 
                   
               
               
                   
                 ctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtgg 
                   
               
               
                   
                 acggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagc 
                   
               
               
                   
                 acctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaa 
                   
               
               
                   
                 gagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc 
                   
               
               
                   
                 agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagcca 
                   
               
               
                   
                 ggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccc 
                   
               
               
                   
                 agcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagac 
                   
               
               
                   
                 caccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgg 
                   
               
               
                   
                 acaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccc 
                   
               
               
                   
                 tgcacaaccactacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg 
                 NO: 325 
               
               
                   
                 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca 
                   
               
               
                   
                 acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac 
                   
               
               
                   
                 cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg 
                   
               
               
                   
                 cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagcc 
                   
               
               
                   
                 caaggccgcccccgacatccagatgacccagagccccagcagcctgtctgccagcgt 
                   
               
               
                   
                 gggcgacagagtgaccatcacctgtcaggccagccagaacatctacgtgtggctgaa 
                   
               
               
                   
                 ctggtatcagcagaagcccggcaaggcccccaagctgctgatctacaaggccagcaa 
                   
               
               
                   
                 cctgcacaccggcgtgcccagcagattttctggcagcggctccggcaccgacttcacc 
                   
               
               
                   
                 ctgacaatcagctccctgcagcccgaggacattgccacctactactgccagcagggcc 
                   
               
               
                   
                 agacctacccctacacctttggccagggcaccaagctggaaatcaagaccaagggcc 
                   
               
               
                   
                 ccagccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagct 
                   
               
               
                   
                 gaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcc 
                   
               
               
                   
                 aaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagcgt 
                   
               
               
                   
                 gaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgacactga 
                   
               
               
                   
                 gcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggc 
                   
               
               
                   
                 ctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 35 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishe 
                 SEQ ID 
               
               
                   
                 gdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydd 
                 NO: 326 
               
               
                   
                 dgalnwavdvdylsnlefwgqgtavtvssastkgpsvfplapcsrstsestaalgclv 
                   
               
               
                   
                 kdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdh 
                   
               
               
                   
                 kpsntkvdkrveskygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvv 
                   
               
               
                   
                 vdvsqedpevqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwlngke 
                   
               
               
                   
                 ykckvsnkglpssiektiskakgqprepqvytlppcqeemtknqvslwclvkgfyp 
                   
               
               
                   
                 sdiavewesngqpennykttppvldsdgsfflyskltvdksrwqegnvfscsvmhe 
                   
               
               
                   
                 alhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr 
                 SEQ ID 
               
               
                   
                 asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrtva 
                 NO: 327 
               
               
                   
                 apsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds 
                   
               
               
                   
                 kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgvi 
                 SEQ ID 
               
               
                   
                 wagggtnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysy 
                 NO: 328 
               
               
                   
                 yysmdywgqgttvtvsssqvqlvesgggvvqpgrslrlscaasgftftkaw 
                   
               
               
                   
                 mhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskntlylq 
                   
               
               
                   
                 mnslraedtavyycrgvyyalspfdywgqgtlvtvssrtastkgpsvfplapc 
                   
               
               
                   
                 srstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv 
                   
               
               
                   
                 tvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggpsvf 
                   
               
               
                   
                 lfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnaktkp 
                   
               
               
                   
                 reeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgqpr 
                   
               
               
                   
                 epqvctlppsqeemtknqvslscavkgfypsdiavewesngqpennyktt 
                   
               
               
                   
                 ppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs 
                 SEQ ID 
               
               
                   
                 nrfsgvpdrfsgsgsgtclftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp 
                 NO: 329 
               
               
                   
                 kaapdivltqspaslayspgqratitcrasesveyyvtslmqwyqqkpgqppkllifa 
                   
               
               
                   
                 asnvesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikt 
                   
               
               
                   
                 kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq 
                   
               
               
                   
                 esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 35 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaa 
                 SEQ ID 
               
               
                   
                 ggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgc 
                 NO: 330 
               
               
                   
                 agcgtgccaggacagggactgcagtggatgggctggatcagccacgagggcgacaa 
                   
               
               
                   
                 gaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggacagaagcac 
                   
               
               
                   
                 caacaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactact 
                   
               
               
                   
                 gcgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacggc 
                   
               
               
                   
                 gccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggccagg 
                   
               
               
                   
                 gcacagccgtgaccgtgtcatctgcttcgaccaagggcccctcggtgttccctctggcc 
                   
               
               
                   
                 ccttgcagcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggact 
                   
               
               
                   
                 actttcccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcac 
                   
               
               
                   
                 acctttccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagt 
                   
               
               
                   
                 gcccagcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagccca 
                   
               
               
                   
                 gcaacaccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttg 
                   
               
               
                   
                 cccagcccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaagg 
                   
               
               
                   
                 acaccctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtccca 
                   
               
               
                   
                 ggaagatcccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgc 
                   
               
               
                   
                 caagaccaagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgct 
                   
               
               
                   
                 gaccgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaa 
                   
               
               
                   
                 caagggcctgcccagctccatcgagaaaaccatcagcaaggccaagggccagcccc 
                   
               
               
                   
                 gcgagcctcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggt 
                   
               
               
                   
                 gtccctgtggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggaga 
                   
               
               
                   
                 gcaacggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgac 
                   
               
               
                   
                 ggctcattcttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggca 
                   
               
               
                   
                 acgtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtc 
                   
               
               
                   
                 cctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccactccctgatccacggcgaccggaacaactacctg 
                 NO: 331 
               
               
                   
                 gcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggccagca 
                   
               
               
                   
                 gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggacttca 
                   
               
               
                   
                 ccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgcagg 
                   
               
               
                   
                 gcagagagagcccctggacctttggccagggcaccaaggtggacatcaagcgtacg 
                   
               
               
                   
                 gtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggca 
                   
               
               
                   
                 cagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtgg 
                   
               
               
                   
                 aaggtggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcagg 
                   
               
               
                   
                 acagcaaggactccacctacagcctgagcagcaccctgacactgagcaaggccgact 
                   
               
               
                   
                 acgagaagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccg 
                   
               
               
                   
                 tgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagc 
                 SEQ ID 
               
               
                   
                 ctgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcc 
                 NO: 332 
               
               
                   
                 agccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcacc 
                   
               
               
                   
                 aactacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaac 
                   
               
               
                   
                 caggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcg 
                   
               
               
                   
                 ccagagacaagggctacagctactactacagcatggactactggggccagggcacca 
                   
               
               
                   
                 ccgtgaccgtgtcatcctctcaggtgcagctggtggaatctggcggcggagtggtgca 
                   
               
               
                   
                 gcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaaggc 
                   
               
               
                   
                 ctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggcccagat 
                   
               
               
                   
                 caaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccggt 
                   
               
               
                   
                 tcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctgc 
                   
               
               
                   
                 gggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcccctt 
                   
               
               
                   
                 cgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcgaccaag 
                   
               
               
                   
                 ggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagccg 
                   
               
               
                   
                 ccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactct 
                   
               
               
                   
                 ggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctgt 
                   
               
               
                   
                 actctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctaca 
                   
               
               
                   
                 cctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatcta 
                   
               
               
                   
                 agtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgtgt 
                   
               
               
                   
                 tcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgac 
                   
               
               
                   
                 ctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtgg 
                   
               
               
                   
                 acggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagc 
                   
               
               
                   
                 acctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaa 
                   
               
               
                   
                 gagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc 
                   
               
               
                   
                 agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagcca 
                   
               
               
                   
                 ggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccc 
                   
               
               
                   
                 agcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagac 
                   
               
               
                   
                 caccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgg 
                   
               
               
                   
                 acaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccc 
                   
               
               
                   
                 tgcacaaccactacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg 
                 NO: 333 
               
               
                   
                 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca 
                   
               
               
                   
                 acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac 
                   
               
               
                   
                 cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg 
                   
               
               
                   
                 cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagcc 
                   
               
               
                   
                 caaggccgcccccgacatcgtgctgacacagagccctgctagcctggccgtgtctcct 
                   
               
               
                   
                 ggacagagggccaccatcacctgtagagccagcgagagcgtggaatattacgtgacc 
                   
               
               
                   
                 agcctgatgcagtggtatcagcagaagcccggccagccccccaagctgctgattttcg 
                   
               
               
                   
                 ccgccagcaacgtggaaagcggcgtgccagccagattttccggcagcggctctggca 
                   
               
               
                   
                 ccgacttcaccctgaccatcaaccccgtggaagccaacgacgtggccaactactactg 
                   
               
               
                   
                 ccagcagagccggaaggtgccctacacctttggccagggcaccaagctggaaatcaa 
                   
               
               
                   
                 gaccaagggccccagccgtacggtggccgctcccagcgtgttcatcttcccacctagc 
                   
               
               
                   
                 gacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctaccc 
                   
               
               
                   
                 ccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagc 
                   
               
               
                   
                 caggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcac 
                   
               
               
                   
                 cctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgac 
                   
               
               
                   
                 ccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 36 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlkpr 
                 SEQ ID 
               
               
                   
                 ggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdfehw 
                 NO: 334 
               
               
                   
                 grgtpvivssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsg 
                   
               
               
                   
                 vhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcp 
                   
               
               
                   
                 pcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgv 
                   
               
               
                   
                 evhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiska 
                   
               
               
                   
                 kgqprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykt 
                   
               
               
                   
                 tppvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Eivltqspgtlslspgetaiiscrtsqygslawyqqrpgqaprlviysgstraagipdrfs 
                 SEQ ID 
               
               
                   
                 gsrwgpdynltisnlesgclfgvyycqqyeffgqgtkvqvdikrtvaapsvfifppsd 
                 NO: 335 
               
               
                   
                 eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl 
                   
               
               
                   
                 skadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvqlvqsgaevvkpgasvkvsckas  ihwyrqapgqglewigs   
                 SEQ ID 
               
               
                   
                    nyaqkfqgratltvdtsistaymelsrlrsddtavyyc   
                 NO: 336 
               
               
                   
                    wgkgttvtvsssqvqlvesgggvvqpgrslrlscaas  m 
                   
               
               
                   
                 hwvrqapgkqlewvaq  yatyyadsvkgrftisrddskntlylqm 
                   
               
               
                   
                 nslraedtavyyc  wgqgflvtvssrtastkgpsvfplapcsr 
                   
               
               
                   
                 stsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvt 
                   
               
               
                   
                 vpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggpsvfl 
                   
               
               
                   
                 fppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnaktkpr 
                   
               
               
                   
                 eeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgqpr 
                   
               
               
                   
                 epqvctlppsqeemtknqvslscavkgfypsdiavewesngqpennyktt 
                   
               
               
                   
                 ppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslslslg 
                   
               
               
                   
                 k 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckss  lswylqkpgqspqsliy   
                 SEQ ID 
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyyc  ftfgsgtkveikgqp 
                 NO: 337 
               
               
                   
                 kaapdiqmtqspsslsasvgdrvtitcqas  lnwyqqkpgkapklliy   
                   
               
               
                   
                 nlhtgvpsrfsgsgsgtdftltisslqpediatyyc  fgqgtkleiktkgpsr 
                   
               
               
                   
                 tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvte 
                   
               
               
                   
                 qdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 36 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgcg 
                 SEQ ID 
               
               
                   
                 gatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatcaga 
                 NO: 338 
               
               
                   
                 ctggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcggagc 
                   
               
               
                   
                 cgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgtgtacag 
                   
               
               
                   
                 cgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgtgtacttct 
                   
               
               
                   
                 gcacccggggcaagaactgcgactacaactgggacttcgagcactggggcagaggc 
                   
               
               
                   
                 acccctgtgatcgtgtcaagcgcgtcgaccaagggcccctcggtgttccctctggcccc 
                   
               
               
                   
                 ttgcagcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactac 
                   
               
               
                   
                 tttcccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacac 
                   
               
               
                   
                 ctttccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgc 
                   
               
               
                   
                 ccagcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagca 
                   
               
               
                   
                 acaccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgccc 
                   
               
               
                   
                 agcccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggaca 
                   
               
               
                   
                 ccctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccagga 
                   
               
               
                   
                 agatcccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaa 
                   
               
               
                   
                 gaccaagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgac 
                   
               
               
                   
                 cgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaa 
                   
               
               
                   
                 gggcctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcg 
                   
               
               
                   
                 agcctcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtc 
                   
               
               
                   
                 cctgtggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagca 
                   
               
               
                   
                 acggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggc 
                   
               
               
                   
                 tcattcttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgt 
                   
               
               
                   
                 gttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgt 
                   
               
               
                   
                 ctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 Gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacagcc 
                 SEQ ID 
               
               
                   
                 atcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagaggcct 
                 NO: 339 
               
               
                   
                 ggacaggcccccagactcgtgatctacagcggcagcacaagagccgccggaatccc 
                   
               
               
                   
                 cgatagattcagcggctccagatggggccctgactacaacctgaccatcagcaacctg 
                   
               
               
                   
                 gaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcggccagggca 
                   
               
               
                   
                 ccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtgttcatcttccca 
                   
               
               
                   
                 cctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaactt 
                   
               
               
                   
                 ctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggca 
                   
               
               
                   
                 acagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagc 
                   
               
               
                   
                 agcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcga 
                   
               
               
                   
                 agtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtg 
                   
               
               
                   
                 t 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaag 
                 SEQ ID 
               
               
                   
                 gtgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgcca 
                 NO: 340 
               
               
                   
                 ggcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacac 
                   
               
               
                   
                 caactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcag 
                   
               
               
                   
                 caccgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactg 
                   
               
               
                   
                 cacccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccac 
                   
               
               
                   
                 cgtgacagtgtctagcagccaggtgcagctggtggaatctggcggcggagtggtgca 
                   
               
               
                   
                 gcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaaggc 
                   
               
               
                   
                 ctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggcccagat 
                   
               
               
                   
                 caaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccggt 
                   
               
               
                   
                 tcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctgc 
                   
               
               
                   
                 gggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcccctt 
                   
               
               
                   
                 cgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgccagcacaaa 
                   
               
               
                   
                 gggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagcc 
                   
               
               
                   
                 gccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactc 
                   
               
               
                   
                 tggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctg 
                   
               
               
                   
                 tactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctaca 
                   
               
               
                   
                 cctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatcta 
                   
               
               
                   
                 agtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgtgt 
                   
               
               
                   
                 tcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgac 
                   
               
               
                   
                 ctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtgg 
                   
               
               
                   
                 acggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagc 
                   
               
               
                   
                 acctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaa 
                   
               
               
                   
                 gagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc 
                   
               
               
                   
                 agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagcca 
                   
               
               
                   
                 ggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccc 
                   
               
               
                   
                 agcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagac 
                   
               
               
                   
                 caccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgg 
                   
               
               
                   
                 acaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccc 
                   
               
               
                   
                 tgcacaaccactacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg 
                 NO: 341 
               
               
                   
                 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca 
                   
               
               
                   
                 acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac 
                   
               
               
                   
                 cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg 
                   
               
               
                   
                 cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagcc 
                   
               
               
                   
                 caaggccgcccccgacatccagatgacccagagccccagcagcctgtctgccagcgt 
                   
               
               
                   
                 gggcgacagagtgaccatcacctgtcaggccagccagaacatctacgtgtggctgaa 
                   
               
               
                   
                 ctggtatcagcagaagcccggcaaggcccccaagctgctgatctacaaggccagcaa 
                   
               
               
                   
                 cctgcacaccggcgtgcccagcagattttctggcagcggctccggcaccgacttcacc 
                   
               
               
                   
                 ctgacaatcagctccctgcagcccgaggacattgccacctactactgccagcagggcc 
                   
               
               
                   
                 agacctacccctacacctttggccagggcaccaagctggaaatcaagaccaagggcc 
                   
               
               
                   
                 ccagccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagct 
                   
               
               
                   
                 gaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcc 
                   
               
               
                   
                 aaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagcgt 
                   
               
               
                   
                 gaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgacactga 
                   
               
               
                   
                 gcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggc 
                   
               
               
                   
                 ctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 37 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlkpr 
                 SEQ ID 
               
               
                   
                 ggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdfehw 
                 NO: 342 
               
               
                   
                 grgtpvivssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsg 
                   
               
               
                   
                 vhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcp 
                   
               
               
                   
                 pcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgv 
                   
               
               
                   
                 evhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiska 
                   
               
               
                   
                 kgqprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykt 
                   
               
               
                   
                 tppvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Eivltqspgtlslspgetaiiscrtsqygslawyqqrpgqaprlviysgstraagipdrfs 
                 SEQ ID 
               
               
                   
                 gsrwgpdynltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifppsd 
                 NO: 343 
               
               
                   
                 eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl 
                   
               
               
                   
                 skadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgvi 
                 SEQ ID 
               
               
                   
                 wagggtnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysy 
                 NO: 344 
               
               
                   
                 yysmdywgqgttvtvsssqvqlvesgggvvqpgrslrlscaasgftftkaw 
                   
               
               
                   
                 mhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskntlylq 
                   
               
               
                   
                 mnslraedtavyycrgvyyalspfdywgqgtlvtvssrtastkgpsvfplapc 
                   
               
               
                   
                 srstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv 
                   
               
               
                   
                 tvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggpsvf 
                   
               
               
                   
                 lfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnaktkp 
                   
               
               
                   
                 reeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgqpr 
                   
               
               
                   
                 epqvctlppsqeemtknqvslscavkgfypsdiavewesngqpennyktt 
                   
               
               
                   
                 ppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs 
                 SEQ ID 
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp 
                 NO: 345 
               
               
                   
                 kaapdivltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifa 
                   
               
               
                   
                 asnvesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikt 
                   
               
               
                   
                 kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq 
                   
               
               
                   
                 esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 37 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgcg 
                 SEQ ID 
               
               
                   
                 gatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatcaga 
                 NO: 346 
               
               
                   
                 ctggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcggagc 
                   
               
               
                   
                 cgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgtgtacag 
                   
               
               
                   
                 cgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgtgtacttctg 
                   
               
               
                   
                 cacccggggcaagaactgcgactacaactgggacttcgagcactggggcagaggca 
                   
               
               
                   
                 cccctgtgatcgtgtcaagcgcgtcgaccaagggcccctcggtgaccctctggcccctt 
                   
               
               
                   
                 gcagcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactt 
                   
               
               
                   
                 tcccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacc 
                   
               
               
                   
                 tttccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcc 
                   
               
               
                   
                 cagcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaa 
                   
               
               
                   
                 caccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgccca 
                   
               
               
                   
                 gcccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacac 
                   
               
               
                   
                 cctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaa 
                   
               
               
                   
                 gatcccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaaga 
                   
               
               
                   
                 ccaagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgt 
                   
               
               
                   
                 gctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggg 
                   
               
               
                   
                 cctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagc 
                   
               
               
                   
                 ctcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctg 
                   
               
               
                   
                 tggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacg 
                   
               
               
                   
                 gccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcat 
                   
               
               
                   
                 tcttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctct 
                   
               
               
                   
                 gtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 Gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacagcc 
                 SEQ ID 
               
               
                   
                 atcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagaggcctg 
                 NO: 347 
               
               
                   
                 gacaggcccccagactcgtgatctacagcggcagcacaagagccgccggaatcccc 
                   
               
               
                   
                 gatagattcagcggctccagatggggccctgactacaacctgaccatcagcaacctgg 
                   
               
               
                   
                 aaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcggccagggcac 
                   
               
               
                   
                 caaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtgttcatcttcccac 
                   
               
               
                   
                 ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttc 
                   
               
               
                   
                 tacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaa 
                   
               
               
                   
                 cagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagca 
                   
               
               
                   
                 gcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaag 
                   
               
               
                   
                 tgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagcc 
                 SEQ ID 
               
               
                   
                 tgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcca 
                 NO: 348 
               
               
                   
                 gccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcaccaa 
                   
               
               
                   
                 ctacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaacca 
                   
               
               
                   
                 ggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcgcc 
                   
               
               
                   
                 agagacaagggctacagctactactacagcatggactactggggccagggcaccacc 
                   
               
               
                   
                 gtgaccgtgtcatcctctcaggtgcagctggtggaatctggcggcggagtggtgcagc 
                   
               
               
                   
                 ctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaaggcctg 
                   
               
               
                   
                 gatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggcccagatcaa 
                   
               
               
                   
                 ggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccggttcac 
                   
               
               
                   
                 catcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctgcgggc 
                   
               
               
                   
                 cgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagccccttcgatta 
                   
               
               
                   
                 ctggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcgaccaagggccc 
                   
               
               
                   
                 atcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagccgccctgg 
                   
               
               
                   
                 gctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactctggcgctc 
                   
               
               
                   
                 tgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctgtactctctg 
                   
               
               
                   
                 agcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctacacctgtaac 
                   
               
               
                   
                 gtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatctaagtacgg 
                   
               
               
                   
                 ccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgtgttcctgttc 
                   
               
               
                   
                 cccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgacctgcgtg 
                   
               
               
                   
                 gtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtggacggcgt 
                   
               
               
                   
                 ggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagcacctacc 
                   
               
               
                   
                 gggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaagagtacaa 
                   
               
               
                   
                 gtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatcagcaaggc 
                   
               
               
                   
                 caagggccagccccgcgagcctcaagtgtgtaccctgccccctagccaggaagagat 
                   
               
               
                   
                 gaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctaccccagcgacattg 
                   
               
               
                   
                 ccgtggaatgggagagcaacggccagcccgagaacaactacaagaccaccccccct 
                   
               
               
                   
                 gtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtggacaagagccg 
                   
               
               
                   
                 gtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccctgcacaaccac 
                   
               
               
                   
                 tacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcca 
                 SEQ ID 
               
               
                   
                 gcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctga 
                 NO: 349 
               
               
                   
                 gctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtccaa 
                   
               
               
                   
                 cagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcacc 
                   
               
               
                   
                 ctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccagggc 
                   
               
               
                   
                 acccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagccca 
                   
               
               
                   
                 aggccgcccccgacatcgtgctgacacagagccctgctagcctggccgtgtctcctgg 
                   
               
               
                   
                 acagagggccaccatcacctgtagagccagcgagagcgtggaatattacgtgaccag 
                   
               
               
                   
                 cctgatgcagtggtatcagcagaagcccggccagccccccaagctgctgattttcgccg 
                   
               
               
                   
                 ccagcaacgtggaaagcggcgtgccagccagattttccggcagcggctctggcaccg 
                   
               
               
                   
                 acttcaccctgaccatcaaccccgtggaagccaacgacgtggccaactactactgcca 
                   
               
               
                   
                 gcagagccggaaggtgccctacacctttggccagggcaccaagctggaaatcaagac 
                   
               
               
                   
                 caagggccccagccgtacggtggccgctcccagcgtgttcatcttcccacctagcgac 
                   
               
               
                   
                 gagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccg 
                   
               
               
                   
                 cgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccag 
                   
               
               
                   
                 gaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccct 
                   
               
               
                   
                 gacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgaccca 
                   
               
               
                   
                 ccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 38 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypgn 
                 SEQ ID 
               
               
                   
                 vntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvvvgkg 
                 NO: 350 
               
               
                   
                 ttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtf 
                   
               
               
                   
                 pavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcp 
                   
               
               
                   
                 apeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevh 
                   
               
               
                   
                 naktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgq 
                   
               
               
                   
                 prepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttpp 
                   
               
               
                   
                 vldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht 
                 SEQ ID 
               
               
                   
                 gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi 
                 NO: 351 
               
               
                   
                 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwi 
                 SEQ ID 
               
               
                   
                 kpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsyg 
                 NO: 352 
               
               
                   
                 dsswaldawgqgttvvvsasqvqlvesgggvvqpgrslrlscaasgftftka 
                   
               
               
                   
                 wmhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskntly 
                   
               
               
                   
                 lqmnslraedtavyycrgvyyalspfdywgqgtlvtvssrtastkgpsvfpla 
                   
               
               
                   
                 pcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss 
                   
               
               
                   
                 vvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggps 
                   
               
               
                   
                 vflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnakt 
                   
               
               
                   
                 kpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg 
                   
               
               
                   
                 qprepqvctlppsqeemtknqvslscavkgfypsdiavewesngqpenny 
                   
               
               
                   
                 kttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslsls 
                   
               
               
                   
                 lgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs 
                 SEQ ID 
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp 
                 NO: 353 
               
               
                   
                 kaapyihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssv 
                   
               
               
                   
                 edgvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhiktkgpsrtvaaps 
                   
               
               
                   
                 vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskds 
                   
               
               
                   
                 tyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 38 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg 
                 SEQ ID 
               
               
                   
                 tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag 
                 NO: 354 
               
               
                   
                 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc 
                   
               
               
                   
                 aactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcagc 
                   
               
               
                   
                 accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc 
                   
               
               
                   
                 acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc 
                   
               
               
                   
                 gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag 
                   
               
               
                   
                 cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc 
                   
               
               
                   
                 gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc 
                   
               
               
                   
                 agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc 
                   
               
               
                   
                 agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc 
                   
               
               
                   
                 aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc 
                   
               
               
                   
                 ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga 
                   
               
               
                   
                 tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc 
                   
               
               
                   
                 cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa 
                   
               
               
                   
                 gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg 
                   
               
               
                   
                 caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg 
                   
               
               
                   
                 cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca 
                   
               
               
                   
                 agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt 
                   
               
               
                   
                 gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc 
                   
               
               
                   
                 ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc 
                   
               
               
                   
                 ctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 Gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagt 
                 SEQ ID 
               
               
                   
                 gaccatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcaga 
                 NO: 355 
               
               
                   
                 agcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggc 
                   
               
               
                   
                 gtgcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctc 
                   
               
               
                   
                 cctgcagcccgaggacattgccacctactactgccagcagggccagacctacccctac 
                   
               
               
                   
                 acctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgt 
                   
               
               
                   
                 tcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctg 
                   
               
               
                   
                 ctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgc 
                   
               
               
                   
                 agagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccaccta 
                   
               
               
                   
                 cagcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgta 
                   
               
               
                   
                 cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccg 
                   
               
               
                   
                 gggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcgg 
                 SEQ ID 
               
               
                   
                 gtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccggcag 
                 NO: 356 
               
               
                   
                 gcccctggcagaggactggaatgggtgggatggatcaagccccagtatggcgccgtg 
                   
               
               
                   
                 aacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgcgag 
                   
               
               
                   
                 atcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactactgcg 
                   
               
               
                   
                 ccagagacagaagctacggcgacagcagctgggctctggatgcttggggccagggc 
                   
               
               
                   
                 acaaccgtggtggtgtctgcctctcaggtgcagctggtggaatctggcggcggagtggt 
                   
               
               
                   
                 gcagcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaag 
                   
               
               
                   
                 gcctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggcccag 
                   
               
               
                   
                 atcaaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccg 
                   
               
               
                   
                 gttcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctg 
                   
               
               
                   
                 cgggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcccctt 
                   
               
               
                   
                 cgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcgaccaag 
                   
               
               
                   
                 ggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagccg 
                   
               
               
                   
                 ccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactctg 
                   
               
               
                   
                 gcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctgta 
                   
               
               
                   
                 ctctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctacacc 
                   
               
               
                   
                 tgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatctaag 
                   
               
               
                   
                 tacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgtgttc 
                   
               
               
                   
                 ctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgacct 
                   
               
               
                   
                 gcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtggac 
                   
               
               
                   
                 ggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagcac 
                   
               
               
                   
                 ctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaagag 
                   
               
               
                   
                 tacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatcagca 
                   
               
               
                   
                 aggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagccaggaag 
                   
               
               
                   
                 agatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctaccccagcga 
                   
               
               
                   
                 cattgccgtggaatgggagagcaacggccagcccgagaacaactacaagaccaccc 
                   
               
               
                   
                 cccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtggacaag 
                   
               
               
                   
                 agccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccctgcac 
                   
               
               
                   
                 aaccactacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 Gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg 
                 NO: 357 
               
               
                   
                 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca 
                   
               
               
                   
                 acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac 
                   
               
               
                   
                 cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg 
                   
               
               
                   
                 cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagccc 
                   
               
               
                   
                 aaggccgccccctacatccacgtgacccagagccccagcagcctgtccgtgtccatcg 
                   
               
               
                   
                 gcgacagagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcact 
                   
               
               
                   
                 ggtatcagcacaagcctggcagagcccccaagctgctgatccaccacacaagcagcg 
                   
               
               
                   
                 tggaagatggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacctg 
                   
               
               
                   
                 accatcagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttc 
                   
               
               
                   
                 ttcggcagaggcagcagactgcacatcaagaccaagggccccagccgtacggtggc 
                   
               
               
                   
                 cgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcct 
                   
               
               
                   
                 ctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtg 
                   
               
               
                   
                 gacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagca 
                   
               
               
                   
                 aggactccacctacagcctgagcagcaccctgacactgagcaaggccgactacgaga 
                   
               
               
                   
                 agcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgacca 
                   
               
               
                   
                 agagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 39 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypgn 
                 SEQ ID 
               
               
                   
                 vntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgkg 
                 NO: 358 
               
               
                   
                 ttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtf 
                   
               
               
                   
                 pavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcp 
                   
               
               
                   
                 apeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevh 
                   
               
               
                   
                 naktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgq 
                   
               
               
                   
                 prepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttpp 
                   
               
               
                   
                 vldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht 
                 SEQ ID 
               
               
                   
                 gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi 
                 NO: 359 
               
               
                   
                 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwi 
                 SEQ ID 
               
               
                   
                 kpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsyg 
                 NO: 360 
               
               
                   
                 dsswaldawgqgttvvvsadkthtqvqlvesgggvvqpgrslrlscansgftf 
                   
               
               
                   
                 tkawmhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskn 
                   
               
               
                   
                 tlylqmnslraedtavyycrgvyyalspfdywgqgtlvtvssdkthtastkgp 
                   
               
               
                   
                 svfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss 
                   
               
               
                   
                 glyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpap 
                   
               
               
                   
                 eflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgve 
                   
               
               
                   
                 vhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiekti 
                   
               
               
                   
                 skakgqprepqvctlppsqeemtknqvslscavkgfypsdiavewesngq 
                   
               
               
                   
                 pennykttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytq 
                   
               
               
                   
                 kslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs 
                 SEQ ID 
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkth 
                 NO: 361 
               
               
                   
                 tyihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg 
                   
               
               
                   
                 vpsrfsgsgfhtsflitisdlqaddiatyycqvlqffgrgsrlhikdkthtrtvaapsvfif 
                   
               
               
                   
                 ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl 
                   
               
               
                   
                 sstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 39 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg 
                 SEQ ID 
               
               
                   
                 tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag 
                 NO: 362 
               
               
                   
                 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc 
                   
               
               
                   
                 aactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcagc 
                   
               
               
                   
                 accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc 
                   
               
               
                   
                 acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc 
                   
               
               
                   
                 gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag 
                   
               
               
                   
                 cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc 
                   
               
               
                   
                 gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc 
                   
               
               
                   
                 agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc 
                   
               
               
                   
                 agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc 
                   
               
               
                   
                 aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc 
                   
               
               
                   
                 ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga 
                   
               
               
                   
                 tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc 
                   
               
               
                   
                 cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa 
                   
               
               
                   
                 gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg 
                   
               
               
                   
                 caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg 
                   
               
               
                   
                 cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca 
                   
               
               
                   
                 agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt 
                   
               
               
                   
                 gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc 
                   
               
               
                   
                 ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc 
                   
               
               
                   
                 ctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagtg 
                 SEQ ID 
               
               
                   
                 accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa 
                 NO: 363 
               
               
                   
                 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt 
                   
               
               
                   
                 gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc 
                   
               
               
                   
                 tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac 
                   
               
               
                   
                 ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc 
                   
               
               
                   
                 atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct 
                   
               
               
                   
                 gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca 
                   
               
               
                   
                 gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac 
                   
               
               
                   
                 agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgtac 
                   
               
               
                   
                 gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg 
                   
               
               
                   
                 ggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcgg 
                 SEQ ID 
               
               
                   
                 gtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctgguccggcag 
                 NO: 364 
               
               
                   
                 gcccctggcagaggactggaatgggtgggatggatcaagccccagtatggcgccgtg 
                   
               
               
                   
                 aacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgcgag 
                   
               
               
                   
                 atcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactactgcg 
                   
               
               
                   
                 ccagagacagaagctacggcgacagcagctgggctctggatgcttggggccagggc 
                   
               
               
                   
                 acaaccgtggtggtgtctgccgacaaaacccatacccaggtgcagctggtggaatctg 
                   
               
               
                   
                 gcggcggagtggtgcagcctggcagaagcctgagactgagctgtgccgccagcggc 
                   
               
               
                   
                 ttcaccttcaccaaggcctggatgcactgggtgcgccaggcccctggaaagcagctgg 
                   
               
               
                   
                 aatgggtggcccagatcaaggacaagagcaacagctacgccacctactacgccgaca 
                   
               
               
                   
                 gcgtgaagggccggttcaccatcagccgggacgacagcaagaacaccctgtacctgc 
                   
               
               
                   
                 agatgaacagcctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtacta 
                   
               
               
                   
                 tgccctgagccccttcgattactggggccagggaaccctcgtgaccgtgtctagtgataa 
                   
               
               
                   
                 gacccacaccgcttcgaccaagggcccatcggtgttccctctggccccttgcagcaga 
                   
               
               
                   
                 agcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccgagc 
                   
               
               
                   
                 ccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccagcc 
                   
               
               
                   
                 gtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagcagca 
                   
               
               
                   
                 gcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaagg 
                   
               
               
                   
                 tggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccctgaa 
                   
               
               
                   
                 tttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctgatgatc 
                   
               
               
                   
                 agccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcccgag 
                   
               
               
                   
                 gtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccca 
                   
               
               
                   
                 gagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcacca 
                   
               
               
                   
                 ggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgcccag 
                   
               
               
                   
                 ctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctcaagtgtg 
                   
               
               
                   
                 taccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagctgtgcc 
                   
               
               
                   
                 gtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggccagccc 
                   
               
               
                   
                 gagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcctggt 
                   
               
               
                   
                 gtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagctgctc 
                   
               
               
                   
                 cgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccctgg 
                   
               
               
                   
                 gcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcca 
                 SEQ ID 
               
               
                   
                 gcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctga 
                 NO: 365 
               
               
                   
                 gctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtccaa 
                   
               
               
                   
                 cagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcacc 
                   
               
               
                   
                 ctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccagggc 
                   
               
               
                   
                 acccagtaccccttcacctttggcagcggcaccaaggtggaaatcaaggacaaaaccc 
                   
               
               
                   
                 atacctacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacag 
                   
               
               
                   
                 agtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcag 
                   
               
               
                   
                 cacaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagat 
                   
               
               
                   
                 ggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcag 
                   
               
               
                   
                 cgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcag 
                   
               
               
                   
                 aggcagcagactgcacatcaaggataagacccatacccgtacggtggccgctcccag 
                   
               
               
                   
                 cgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtg 
                   
               
               
                   
                 cctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgc 
                   
               
               
                   
                 cctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactcc 
                   
               
               
                   
                 acctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag 
                   
               
               
                   
                 gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttca 
                   
               
               
                   
                 accggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 40 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypg 
                 SEQ ID 
               
               
                   
                 nvntnyaqkfqgratitvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgk 
                 NO: 366 
               
               
                   
                 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht 
                   
               
               
                   
                 fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc 
                   
               
               
                   
                 papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev 
                   
               
               
                   
                 hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg 
                   
               
               
                   
                 qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp 
                   
               
               
                   
                 pvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht 
                 SEQ ID 
               
               
                   
                 gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi 
                 NO: 367 
               
               
                   
                 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdsty 
                   
               
               
                   
                 slsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvqlvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewva 
                 SEQ ID 
               
               
                   
                 qikdksnsyatyyadsvkgrftisrddskntlylqmnstraedtavyycrgvy 
                 NO: 368 
               
               
                   
                 yalspfdywgqgtlvtvsssrahlvqsgtamkkpgasvrvscqtsgytftahi 
                   
               
               
                   
                 lfwfrqapgrglewvgwikpqygavnfgggfrdrvtltrdvyreiaymdirg 
                   
               
               
                   
                 lkpddtavyycardrsygdsswaldawgqgttvvvsartastkgpsvfplap 
                   
               
               
                   
                 csrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssv 
                   
               
               
                   
                 vtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggps 
                   
               
               
                   
                 vflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnakt 
                   
               
               
                   
                 kpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg 
                   
               
               
                   
                 qprepqvctlppsqeemtknqvslscavkgfypsdiavewesngqpenny 
                   
               
               
                   
                 kttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslsls 
                   
               
               
                   
                 lgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg 
                 SEQ ID 
               
               
                   
                 vpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikgqpkaapdivmtqt 
                 NO: 369 
               
               
                   
                 plslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvsnrfsgvpd 
                   
               
               
                   
                 rfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveiktkgpsrtvaaps 
                   
               
               
                   
                 vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskds 
                   
               
               
                   
                 tyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 40 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg 
                 SEQ ID 
               
               
                   
                 tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag 
                 NO: 370 
               
               
                   
                 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc 
                   
               
               
                   
                 aactacgcccagaagaccagggcagagccaccctgaccgtggacaccagcatcagc 
                   
               
               
                   
                 accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc 
                   
               
               
                   
                 acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc 
                   
               
               
                   
                 gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag 
                   
               
               
                   
                 cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc 
                   
               
               
                   
                 gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc 
                   
               
               
                   
                 agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc 
                   
               
               
                   
                 agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc 
                   
               
               
                   
                 aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc 
                   
               
               
                   
                 ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga 
                   
               
               
                   
                 tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc 
                   
               
               
                   
                 cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa 
                   
               
               
                   
                 gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg 
                   
               
               
                   
                 caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg 
                   
               
               
                   
                 cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca 
                   
               
               
                   
                 agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt 
                   
               
               
                   
                 gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc 
                   
               
               
                   
                 ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc 
                   
               
               
                   
                 ctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagtg 
                 SEQ ID 
               
               
                   
                 accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa 
                 NO: 371 
               
               
                   
                 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt 
                   
               
               
                   
                 gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc 
                   
               
               
                   
                 tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac 
                   
               
               
                   
                 ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc 
                   
               
               
                   
                 atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct 
                   
               
               
                   
                 gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca 
                   
               
               
                   
                 gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac 
                   
               
               
                   
                 agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgtac 
                   
               
               
                   
                 gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg 
                   
               
               
                   
                 ggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgaga 
                 SEQ ID 
               
               
                   
                 ctgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgcc 
                 NO: 372 
               
               
                   
                 aggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacagc 
                   
               
               
                   
                 tacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacgac 
                   
               
               
                   
                 agcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccgtg 
                   
               
               
                   
                 tactactgtcggggcgtgtactatgccctgagccccttcgattactggggccagggaac 
                   
               
               
                   
                 cctcgtgaccgtgtctagtagcagagcccacctggtgcagtctggcaccgccatgaag 
                   
               
               
                   
                 aaaccaggcgcctctgtgcgggtgtcctgtcagacaagcggctacaccttcaccgccc 
                   
               
               
                   
                 acatcctgttctggttccggcaggcccctggcagaggactggaatgggtgggatggat 
                   
               
               
                   
                 caagccccagtatggcgccgtgaacttcggcggaggcttccgggatagagtgaccctg 
                   
               
               
                   
                 acccgggacgtgtaccgcgagatcgcctacatggacatccggggcctgaagcccgat 
                   
               
               
                   
                 gacaccgccgtgtactactgcgccagagacagaagctacggcgacagcagctgggct 
                   
               
               
                   
                 ctggatgcttggggccagggcacaaccgtggtggtgtctgcccggaccgccagcaca 
                   
               
               
                   
                 aagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacag 
                   
               
               
                   
                 ccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaac 
                   
               
               
                   
                 tctggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcc 
                   
               
               
                   
                 tgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagaccta 
                   
               
               
                   
                 cacctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatc 
                   
               
               
                   
                 taagtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgt 
                   
               
               
                   
                 gttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtg 
                   
               
               
                   
                 acctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgt 
                   
               
               
                   
                 ggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaaca 
                   
               
               
                   
                 gcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaa 
                   
               
               
                   
                 agagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc 
                   
               
               
                   
                 agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagccag 
                   
               
               
                   
                 gaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccca 
                   
               
               
                   
                 gcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagacc 
                   
               
               
                   
                 accccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgga 
                   
               
               
                   
                 caagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccct 
                   
               
               
                   
                 gcacaaccactacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacag 
                 SEQ ID 
               
               
                   
                 agtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggt 
                 NO: 373 
               
               
                   
                 atcagcacaagcctggcagagcccccaagctgctgatccaccacacaagcag 
                   
               
               
                   
                 cgtggaagatggcgtgcccagcagattttccggcagcggcttccacaccagctt 
                   
               
               
                   
                 caacctgaccatcagcgatctgcaggccgacgacattgccacctactattgtca 
                   
               
               
                   
                 ggtgctgcagttcttcggcagaggcagcagactgcacatcaagggccagccca 
                   
               
               
                   
                 aggccgcccccgacatcgtgatgacccagacccccctgagcctgagcgtgac 
                   
               
               
                   
                 acctggacagcctgccagcatcagctgcaagagcagccagagcctggtgcac 
                   
               
               
                   
                 aacaacgccaacacctacctgagctggtatctgcagaagcccggccagagcc 
                   
               
               
                   
                 cccagtccctgatctacaaggtgtccaacagattcagcggcgtgcccgacagat 
                   
               
               
                   
                 tctccggcagcggctctggcaccgacttcaccctgaagatcagccgggtggaa 
                   
               
               
                   
                 gccgaggacgtgggcgtgtactattgtggccagggcacccagtaccccttcac 
                   
               
               
                   
                 ctttggcagcggcaccaaggtggaaatcaagaccaagggccccagccgtacg 
                   
               
               
                   
                 gtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtcc 
                   
               
               
                   
                 ggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaa 
                   
               
               
                   
                 gtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagc 
                   
               
               
                   
                 gtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctga 
                   
               
               
                   
                 cactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgac 
                   
               
               
                   
                 ccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 41 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypgn 
                 SEQ ID 
               
               
                   
                 vntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgkg 
                 NO: 374 
               
               
                   
                 ttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtf 
                   
               
               
                   
                 pavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcp 
                   
               
               
                   
                 apeflggpsvflfppkpkddmisrtpevtcvvvdvsqedpevqfnwyvdgvevh 
                   
               
               
                   
                 naktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgq 
                   
               
               
                   
                 prepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttpp 
                   
               
               
                   
                 vldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht 
                 SEQ ID 
               
               
                   
                 gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi 
                 NO: 375 
               
               
                   
                 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 qvqlvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaq 
                 SEQ ID 
               
               
                   
                 ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy 
                 NO: 376 
               
               
                   
                 alspfdywgqgtlvtvssdkthtrahlvqsgtamkkpgasvrvscqtsgytft 
                   
               
               
                   
                 ahilfwfrqapgrglewvgwikpqygavnfgggfrdrvtltrdvyreiaym 
                   
               
               
                   
                 dirglkpddtavyycardrsygdsswaldawgqgttvvvsadkthtastkgp 
                   
               
               
                   
                 svfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss 
                   
               
               
                   
                 glyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpap 
                   
               
               
                   
                 eflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgve 
                   
               
               
                   
                 vhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiekti 
                   
               
               
                   
                 skakgqprepqvctlppsqeemtknqvslscavkgfypsdiavewesngq 
                   
               
               
                   
                 pennykttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytq 
                   
               
               
                   
                 kslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Yihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg 
                 SEQ ID 
               
               
                   
                 vpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikdkthtdivmtqtplsl 
                 NO: 377 
               
               
                   
                 svtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvsnrfsgvpdrfs 
                   
               
               
                   
                 gsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkthtrtvaapsvfif 
                   
               
               
                   
                 ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl 
                   
               
               
                   
                 sstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 41 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg 
                 SEQ ID 
               
               
                   
                 tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag 
                 NO: 378 
               
               
                   
                 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc 
                   
               
               
                   
                 aactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcagc 
                   
               
               
                   
                 accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc 
                   
               
               
                   
                 acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc 
                   
               
               
                   
                 gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag 
                   
               
               
                   
                 cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc 
                   
               
               
                   
                 gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc 
                   
               
               
                   
                 agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc 
                   
               
               
                   
                 agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc 
                   
               
               
                   
                 aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc 
                   
               
               
                   
                 ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga 
                   
               
               
                   
                 tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc 
                   
               
               
                   
                 cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa 
                   
               
               
                   
                 gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg 
                   
               
               
                   
                 caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg 
                   
               
               
                   
                 cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca 
                   
               
               
                   
                 agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt 
                   
               
               
                   
                 gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc 
                   
               
               
                   
                 ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc 
                   
               
               
                   
                 ctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagtg 
                 SEQ ID 
               
               
                   
                 accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa 
                 NO: 379 
               
               
                   
                 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt 
                   
               
               
                   
                 gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc 
                   
               
               
                   
                 tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac 
                   
               
               
                   
                 ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc 
                   
               
               
                   
                 atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct 
                   
               
               
                   
                 gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca 
                   
               
               
                   
                 gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac 
                   
               
               
                   
                 agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgtac 
                   
               
               
                   
                 gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg 
                   
               
               
                   
                 ggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgaga 
                 SEQ ID 
               
               
                   
                 ctgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgcc 
                 NO: 380 
               
               
                   
                 aggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacagc 
                   
               
               
                   
                 tacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacgac 
                   
               
               
                   
                 agcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccgtg 
                   
               
               
                   
                 tactactgtcggggcgtgtactatgccctgagccccttcgattactggggccagggaac 
                   
               
               
                   
                 cctcgtgaccgtgtctagtgacaaaacccataccagagcccacctggtgcagtctggca 
                   
               
               
                   
                 ccgccatgaagaaaccaggcgcctctgtgcgggtgtcctgtcagacaagcggctacac 
                   
               
               
                   
                 cttcaccgcccacatcctgttctggttccggcaggcccctggcagaggactggaatggg 
                   
               
               
                   
                 tgggatggatcaagccccagtatggcgccgtgaacttcggcggaggcttccgggatag 
                   
               
               
                   
                 agtgaccctgacccgggacgtgtaccgcgagatcgcctacatggacatccggggcct 
                   
               
               
                   
                 gaagcccgatgacaccgccgtgtactactgcgccagagacagaagctacggcgacag 
                   
               
               
                   
                 cagctgggctctggatgcttggggccagggcacaaccgtggtggtgtctgccgataag 
                   
               
               
                   
                 acccacaccgccagcacaaagggcccatcggtgttccctctggccccttgcagcagaa 
                   
               
               
                   
                 gcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccgagcc 
                   
               
               
                   
                 cgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccagccg 
                   
               
               
                   
                 tgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagcagcag 
                   
               
               
                   
                 cctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaaggt 
                   
               
               
                   
                 ggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccctgaat 
                   
               
               
                   
                 ttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctgatgatca 
                   
               
               
                   
                 gccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcccgagg 
                   
               
               
                   
                 tgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccag 
                   
               
               
                   
                 agaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccag 
                   
               
               
                   
                 gactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgcccagc 
                   
               
               
                   
                 tccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctcaagtgtgt 
                   
               
               
                   
                 accctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagctgtgcc 
                   
               
               
                   
                 gtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggccagccc 
                   
               
               
                   
                 gagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcctggt 
                   
               
               
                   
                 gtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagctgctc 
                   
               
               
                   
                 cgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccctgg 
                   
               
               
                   
                 gcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagtga 
                 SEQ ID 
               
               
                   
                 ccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagcacaa 
                 NO: 381 
               
               
                   
                 gcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagatggcgt 
                   
               
               
                   
                 gcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcagcgatc 
                   
               
               
                   
                 tgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcagaggca 
                   
               
               
                   
                 gcagactgcacatcaaggacaaaacccataccgacatcgtgatgacccagacccccct 
                   
               
               
                   
                 gagcctgagcgtgacacctggacagcctgccagcatcagctgcaagagcagccaga 
                   
               
               
                   
                 gcctggtgcacaacaacgccaacacctacctgagctggtatctgcagaagcccggcca 
                   
               
               
                   
                 gagcccccagtccctgatctacaaggtgtccaacagattcagcggcgtgcccgacaga 
                   
               
               
                   
                 ttctccggcagcggctctggcaccgacttcaccctgaagatcagccgggtggaagccg 
                   
               
               
                   
                 aggacgtgggcgtgtactattgtggccagggcacccagtaccccttcacctttggcagc 
                   
               
               
                   
                 ggcaccaaggtggaaatcaaggataagacccatacccgtacggtggccgctcccagc 
                   
               
               
                   
                 gtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgc 
                   
               
               
                   
                 ctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc 
                   
               
               
                   
                 ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactcca 
                   
               
               
                   
                 cctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag 
                   
               
               
                   
                 gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttca 
                   
               
               
                   
                 accggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 42 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwaggg 
                 SEQ ID 
               
               
                   
                 tnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywgq 
                 NO: 382 
               
               
                   
                 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht 
                   
               
               
                   
                 fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc 
                   
               
               
                   
                 papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev 
                   
               
               
                   
                 hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg 
                   
               
               
                   
                 qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp 
                   
               
               
                   
                 pvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Divltqspaslayspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn 
                 SEQ ID 
               
               
                   
                 vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtvaa 
                 NO: 383 
               
               
                   
                 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk 
                   
               
               
                   
                 dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwi 
                 SEQ ID 
               
               
                   
                 kpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsyg 
                 NO: 384 
               
               
                   
                 dsswaldawgqgttvvvsasqvqlvesgggvvqpgrslrlscaasgftftka 
                   
               
               
                   
                 wmhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskntly 
                   
               
               
                   
                 lqmnslraedtavyycrgvyyalspfdywgqgtlvtvssrtastkgpsvfpla 
                   
               
               
                   
                 pcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss 
                   
               
               
                   
                 vvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggps 
                   
               
               
                   
                 vflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnakt 
                   
               
               
                   
                 kpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg 
                   
               
               
                   
                 qprepqvctlppsqeemtknqvslscavkgfypsdiavewesngqpenny 
                   
               
               
                   
                 kttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslsls 
                   
               
               
                   
                 lgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs 
                 SEQ ID 
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp 
                 NO: 385 
               
               
                   
                 kaapyihvtqspsslsysigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssv 
                   
               
               
                   
                 edgvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhiktkgpsrtvaaps 
                   
               
               
                   
                 vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskds 
                   
               
               
                   
                 tyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 42 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagc 
                 SEQ ID 
               
               
                   
                 ctgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcc 
                 NO: 386 
               
               
                   
                 agccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcacc 
                   
               
               
                   
                 aactacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaac 
                   
               
               
                   
                 caggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcg 
                   
               
               
                   
                 ccagagacaagggctacagctactactacagcatggactactggggccagggcacca 
                   
               
               
                   
                 ccgtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgc 
                   
               
               
                   
                 agcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttc 
                   
               
               
                   
                 ccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacaccttt 
                   
               
               
                   
                 ccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgccca 
                   
               
               
                   
                 gcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaaca 
                   
               
               
                   
                 ccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagc 
                   
               
               
                   
                 ccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccct 
                   
               
               
                   
                 gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagat 
                   
               
               
                   
                 cccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagacc 
                   
               
               
                   
                 aagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtg 
                   
               
               
                   
                 ctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggc 
                   
               
               
                   
                 ctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcc 
                   
               
               
                   
                 tcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgt 
                   
               
               
                   
                 ggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacgg 
                   
               
               
                   
                 ccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt 
                   
               
               
                   
                 cttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctct 
                   
               
               
                   
                 gtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca 
                 SEQ ID 
               
               
                   
                 ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg 
                 NO: 387 
               
               
                   
                 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg 
                   
               
               
                   
                 gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga 
                   
               
               
                   
                 ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga 
                   
               
               
                   
                 aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccg 
                   
               
               
                   
                 ctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctct 
                   
               
               
                   
                 gtcgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtgg 
                   
               
               
                   
                 acaatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaa 
                   
               
               
                   
                 ggactccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaa 
                   
               
               
                   
                 gcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaa 
                   
               
               
                   
                 gagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcgg 
                 SEQ ID 
               
               
                   
                 gtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccggcag 
                 NO: 388 
               
               
                   
                 gcccctggcagaggactggaatgggtgggatggatcaagccccagtatggcgccgtg 
                   
               
               
                   
                 aacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgcgag 
                   
               
               
                   
                 atcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactactgcg 
                   
               
               
                   
                 ccagagacagaagctacggcgacagcagctgggctctggatgcttggggccagggc 
                   
               
               
                   
                 acaaccgtggtggtgtctgcctctcaggtgcagctggtggaatctggcggcggagtgg 
                   
               
               
                   
                 tgcagcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaa 
                   
               
               
                   
                 ggcctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggccc 
                   
               
               
                   
                 agatcaaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggc 
                   
               
               
                   
                 cggttcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagc 
                   
               
               
                   
                 ctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcc 
                   
               
               
                   
                 ccttcgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcgacc 
                   
               
               
                   
                 aagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacag 
                   
               
               
                   
                 ccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaac 
                   
               
               
                   
                 tctggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcc 
                   
               
               
                   
                 tgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagaccta 
                   
               
               
                   
                 cacctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaat 
                   
               
               
                   
                 ctaagtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctcc 
                   
               
               
                   
                 gtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaag 
                   
               
               
                   
                 tgacctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtac 
                   
               
               
                   
                 gtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaa 
                   
               
               
                   
                 cagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacgg 
                   
               
               
                   
                 caaagagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaac 
                   
               
               
                   
                 catcagcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctag 
                   
               
               
                   
                 ccaggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctac 
                   
               
               
                   
                 cccagcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaa 
                   
               
               
                   
                 gaccaccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccg 
                   
               
               
                   
                 tggacaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgagg 
                   
               
               
                   
                 ccctgcacaaccactacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg 
                 NO: 389 
               
               
                   
                 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca 
                   
               
               
                   
                 acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac 
                   
               
               
                   
                 cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg 
                   
               
               
                   
                 cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagcc 
                   
               
               
                   
                 caaggccgccccctacatccacgtgacccagagccccagcagcctgtccgtgtccatc 
                   
               
               
                   
                 ggcgacagagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 
                   
               
               
                   
                 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacacaagcagc 
                   
               
               
                   
                 gtggaagatggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacct 
                   
               
               
                   
                 gaccatcagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagtt 
                   
               
               
                   
                 cttcggcagaggcagcagactgcacatcaagaccaagggccccagccgtacggtgg 
                   
               
               
                   
                 ccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagc 
                   
               
               
                   
                 ctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaagg 
                   
               
               
                   
                 tggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacag 
                   
               
               
                   
                 caaggactccacctacagcctgagcagcaccctgacactgagcaaggccgactacga 
                   
               
               
                   
                 gaagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgac 
                   
               
               
                   
                 caagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 43 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwagg 
                 SEQ ID 
               
               
                   
                 gtnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywg 
                 NO: 390 
               
               
                   
                 qgttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgv 
                   
               
               
                   
                 htfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcpp 
                   
               
               
                   
                 cpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgve 
                   
               
               
                   
                 vhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskak 
                   
               
               
                   
                 gqprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennyktt 
                   
               
               
                   
                 ppvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Divltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn 
                 SEQ ID 
               
               
                   
                 vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtva 
                 NO: 391 
               
               
                   
                 apsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds 
                   
               
               
                   
                 kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwi 
                 SEQ ID 
               
               
                   
                 kpqygavnfgggfrdrytltrdvyreiaymdirglkpddtavyycardrsyg 
                 NO: 392 
               
               
                   
                 dsswaldawgqgttvvvsadkthtqvqlvesgggvvqpgrslrlscaasgft 
                   
               
               
                   
                 ftkawmhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddsk 
                   
               
               
                   
                 ntlylqmnslraedtavyycrgvyyalspfdywgqgtlvtvssdkthtastkg 
                   
               
               
                   
                 psvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs 
                   
               
               
                   
                 sglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpa 
                   
               
               
                   
                 peflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgv 
                   
               
               
                   
                 evhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiek 
                   
               
               
                   
                 tiskakgqprepqvctlppsqeemtknqvslscavkgfypsdiavewesng 
                   
               
               
                   
                 qpennykttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhy 
                   
               
               
                   
                 tqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs 
                 SEQ ID 
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkt 
                 NO: 393 
               
               
                   
                 htyihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved 
                   
               
               
                   
                 gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikdkthtrtvaapsvfi 
                   
               
               
                   
                 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdsty 
                   
               
               
                   
                 slsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 43 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagc 
                 SEQ ID 
               
               
                   
                 ctgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcc 
                 NO: 394 
               
               
                   
                 agccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcacc 
                   
               
               
                   
                 aactacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaac 
                   
               
               
                   
                 caggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcg 
                   
               
               
                   
                 ccagagacaagggctacagctactactacagcatggactactggggccagggcacca 
                   
               
               
                   
                 ccgtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgc 
                   
               
               
                   
                 agcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttc 
                   
               
               
                   
                 ccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacaccttt 
                   
               
               
                   
                 ccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgccca 
                   
               
               
                   
                 gcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaaca 
                   
               
               
                   
                 ccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagc 
                   
               
               
                   
                 ccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccct 
                   
               
               
                   
                 gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagat 
                   
               
               
                   
                 cccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagacc 
                   
               
               
                   
                 aagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtg 
                   
               
               
                   
                 ctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggc 
                   
               
               
                   
                 ctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcc 
                   
               
               
                   
                 tcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgt 
                   
               
               
                   
                 ggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacgg 
                   
               
               
                   
                 ccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt 
                   
               
               
                   
                 cttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctct 
                   
               
               
                   
                 gtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca 
                 SEQ ID 
               
               
                   
                 ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg 
                 NO: 395 
               
               
                   
                 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg 
                   
               
               
                   
                 gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga 
                   
               
               
                   
                 ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga 
                   
               
               
                   
                 aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccg 
                   
               
               
                   
                 ctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctct 
                   
               
               
                   
                 gtcgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtgg 
                   
               
               
                   
                 acaatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaa 
                   
               
               
                   
                 ggactccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaa 
                   
               
               
                   
                 gcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaa 
                   
               
               
                   
                 gagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcgg 
                 SEQ ID 
               
               
                   
                 gtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccggcag 
                 NO: 396 
               
               
                   
                 gcccctggcagaggactggaatgggtgggatggatcaagccccagtatggcgccgtg 
                   
               
               
                   
                 aacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgcgag 
                   
               
               
                   
                 atcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactactgcg 
                   
               
               
                   
                 ccagagacagaagctacggcgacagcagctgggctctggatgcttggggccagggc 
                   
               
               
                   
                 acaaccgtggtggtgtctgccgacaaaacccatacccaggtgcagctggtggaatctg 
                   
               
               
                   
                 gcggcggagtggtgcagcctggcagaagcctgagactgagctgtgccgccagcggc 
                   
               
               
                   
                 ttcaccttcaccaaggcctggatgcactgggtgcgccaggcccctggaaagcagctgg 
                   
               
               
                   
                 aatgggtggcccagatcaaggacaagagcaacagctacgccacctactacgccgaca 
                   
               
               
                   
                 gcgtgaagggccggttcaccatcagccgggacgacagcaagaacaccctgtacctgc 
                   
               
               
                   
                 agatgaacagcctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtact 
                   
               
               
                   
                 atgccctgagccccttcgattactggggccagggaaccctcgtgaccgtgtctagtgat 
                   
               
               
                   
                 aagacccacaccgcttcgaccaagggcccatcggtgttccctctggccccttgcagca 
                   
               
               
                   
                 gaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccga 
                   
               
               
                   
                 gcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccag 
                   
               
               
                   
                 ccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagcag 
                   
               
               
                   
                 cagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaa 
                   
               
               
                   
                 ggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccct 
                   
               
               
                   
                 gaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctgat 
                   
               
               
                   
                 gatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc 
                   
               
               
                   
                 cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa 
                   
               
               
                   
                 gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg 
                   
               
               
                   
                 caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg 
                   
               
               
                   
                 cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca 
                   
               
               
                   
                 agtgtgtaccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagc 
                   
               
               
                   
                 tgtgccgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcc 
                   
               
               
                   
                 agcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattctt 
                   
               
               
                   
                 cctggtgtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcag 
                   
               
               
                   
                 ctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgt 
                   
               
               
                   
                 ccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg 
                 NO: 397 
               
               
                   
                 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca 
                   
               
               
                   
                 acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac 
                   
               
               
                   
                 cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg 
                   
               
               
                   
                 cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaaggacaaaacc 
                   
               
               
                   
                 catacctacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgaca 
                   
               
               
                   
                 gagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatca 
                   
               
               
                   
                 gcacaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaag 
                   
               
               
                   
                 atggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatc 
                   
               
               
                   
                 agcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggc 
                   
               
               
                   
                 agaggcagcagactgcacatcaaggataagacccatacccgtacggtggccgctccc 
                   
               
               
                   
                 agcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgt 
                   
               
               
                   
                 gtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaa 
                   
               
               
                   
                 cgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggac 
                   
               
               
                   
                 tccacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac 
                   
               
               
                   
                 aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagc 
                   
               
               
                   
                 ttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 44 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwaggg 
                 SEQ ID 
               
               
                   
                 tnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywgq 
                 NO: 398 
               
               
                   
                 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht 
                   
               
               
                   
                 fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc 
                   
               
               
                   
                 papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev 
                   
               
               
                   
                 hnaktkpreeqfnstyrvvsvltylhqdwlngkeykckvsnkglpssiektiskakg 
                   
               
               
                   
                 qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp 
                   
               
               
                   
                 pvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Divltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn 
                 SEQ ID 
               
               
                   
                 vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtvaa 
                 NO: 399 
               
               
                   
                 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk 
                   
               
               
                   
                 dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvqlvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaq 
                 SEQ ID 
               
               
                   
                 ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy 
                 NO: 400 
               
               
                   
                 alspfdywgqgtlvtvsssrahlvqsgtamkkpgasvrvscqtsgytftahilf 
                   
               
               
                   
                 wfrqapgrglewvgwikpqygavnfgggfrdrvtltrdvyreiaymdirgl 
                   
               
               
                   
                 kpddtavyycardrsygdsswaldawgqgttvvvsartastkgpsvfplapc 
                   
               
               
                   
                 srstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv 
                   
               
               
                   
                 tvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggpsvf 
                   
               
               
                   
                 lfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnaktkp 
                   
               
               
                   
                 reeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgqpr 
                   
               
               
                   
                 epqvctlppsqeemtknqvslscavkgfypsdiavewesngqpennyktt 
                   
               
               
                   
                 ppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg 
                 SEQ ID 
               
               
                   
                 vpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikgqpkaapdivmtqt 
                 NO: 401 
               
               
                   
                 plslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvsnrfsgvpd 
                   
               
               
                   
                 rfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveiktkgpsrtvaaps 
                   
               
               
                   
                 vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskds 
                   
               
               
                   
                 tyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 44 ucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagc 
                 SEQ ID 
               
               
                   
                 ctgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcc 
                 NO: 402 
               
               
                   
                 agccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcacc 
                   
               
               
                   
                 aactacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaac 
                   
               
               
                   
                 caggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcg 
                   
               
               
                   
                 ccagagacaagggctacagctactactacagcatggactactggggccagggcacca 
                   
               
               
                   
                 ccgtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgc 
                   
               
               
                   
                 agcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttc 
                   
               
               
                   
                 ccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacaccttt 
                   
               
               
                   
                 ccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgccca 
                   
               
               
                   
                 gcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaaca 
                   
               
               
                   
                 ccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagc 
                   
               
               
                   
                 ccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccct 
                   
               
               
                   
                 gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagat 
                   
               
               
                   
                 cccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagacc 
                   
               
               
                   
                 aagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtg 
                   
               
               
                   
                 ctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggc 
                   
               
               
                   
                 ctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcc 
                   
               
               
                   
                 tcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgt 
                   
               
               
                   
                 ggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacgg 
                   
               
               
                   
                 ccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt 
                   
               
               
                   
                 cttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctct 
                   
               
               
                   
                 gtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca 
                 SEQ ID 
               
               
                   
                 ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg 
                 NO: 403 
               
               
                   
                 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg 
                   
               
               
                   
                 gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga 
                   
               
               
                   
                 ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga 
                   
               
               
                   
                 aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccg 
                   
               
               
                   
                 ctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctct 
                   
               
               
                   
                 gtcgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtgg 
                   
               
               
                   
                 acaatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaa 
                   
               
               
                   
                 ggactccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaa 
                   
               
               
                   
                 gcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaa 
                   
               
               
                   
                 gagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgag 
                 SEQ ID 
               
               
                   
                 actgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgc 
                 NO: 404 
               
               
                   
                 caggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacag 
                   
               
               
                   
                 ctacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacga 
                   
               
               
                   
                 cagcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccg 
                   
               
               
                   
                 tgtactactgtcggggcgtgtactatgccctgagccccttcgattactggggccaggga 
                   
               
               
                   
                 accctcgtgaccgtgtctagtagcagagcccacctggtgcagtctggcaccgccatga 
                   
               
               
                   
                 agaaaccaggcgcctctgtgcgggtgtcctgtcagacaagcggctacaccttcaccgc 
                   
               
               
                   
                 ccacatcctgttctggttccggcaggcccctggcagaggactggaatgggtgggatgg 
                   
               
               
                   
                 atcaagccccagtatggcgccgtgaacttcggcggaggcttccgggatagagtgaccc 
                   
               
               
                   
                 tgacccgggacgtgtaccgcgagatcgcctacatggacatccggggcctgaagcccg 
                   
               
               
                   
                 atgacaccgccgtgtactactgcgccagagacagaagctacggcgacagcagctggg 
                   
               
               
                   
                 ctctggatgcttggggccagggcacaaccgtggtggtgtctgcccggaccgccagca 
                   
               
               
                   
                 caaagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctac 
                   
               
               
                   
                 agccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctgg 
                   
               
               
                   
                 aactctggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcg 
                   
               
               
                   
                 gcctgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaaga 
                   
               
               
                   
                 cctacacctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtg 
                   
               
               
                   
                 gaatctaagtacggccctccctgccctccttgcccagcccctgaatttctgggcggacc 
                   
               
               
                   
                 ctccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccccc 
                   
               
               
                   
                 gaagtgacctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattg 
                   
               
               
                   
                 gtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagt 
                   
               
               
                   
                 tcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaa 
                   
               
               
                   
                 cggcaaagagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaa 
                   
               
               
                   
                 aaccatcagcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccc 
                   
               
               
                   
                 tagccaggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttc 
                   
               
               
                   
                 taccccagcgacattgccgtggaatgggagagcaacggccagcccgagaacaacta 
                   
               
               
                   
                 caagaccaccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctga 
                   
               
               
                   
                 ccgtggacaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacg 
                   
               
               
                   
                 aggccctgcacaaccactacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacag 
                 SEQ ID 
               
               
                   
                 agtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggt 
                 NO: 405 
               
               
                   
                 atcagcacaagcctggcagagcccccaagctgctgatccaccacacaagcag 
                   
               
               
                   
                 cgtggaagatggcgtgcccagcagattttccggcagcggcttccacaccagctt 
                   
               
               
                   
                 caacctgaccatcagcgatctgcaggccgacgacattgccacctactattgtca 
                   
               
               
                   
                 ggtgctgcagttcttcggcagaggcagcagactgcacatcaagggccagccc 
                   
               
               
                   
                 aaggccgcccccgacatcgtgatgacccagacccccctgagcctgagcgtga 
                   
               
               
                   
                 cacctggacagcctgccagcatcagctgcaagagcagccagagcctggtgca 
                   
               
               
                   
                 caacaacgccaacacctacctgagctggtatctgcagaagcccggccagagc 
                   
               
               
                   
                 ccccagtccctgatctacaaggtgtccaacagattcagcggcgtgcccgacag 
                   
               
               
                   
                 attctccggcagcggctctggcaccgacttcaccctgaagatcagccgggtgg 
                   
               
               
                   
                 aagccgaggacgtgggcgtgtactattgtggccagggcacccagtaccccttc 
                   
               
               
                   
                 acctttggcagcggcaccaaggtggaaatcaagaccaagggccccagccgta 
                   
               
               
                   
                 cggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagt 
                   
               
               
                   
                 ccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcca 
                   
               
               
                   
                 aagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaa 
                   
               
               
                   
                 gcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccct 
                   
               
               
                   
                 gacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtg 
                   
               
               
                   
                 acccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagt 
                   
               
               
                   
                 gt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 45 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwagg 
                 SEQ ID 
               
               
                   
                 gtnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywg 
                 NO: 406 
               
               
                   
                 qgttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgv 
                   
               
               
                   
                 htfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcpp 
                   
               
               
                   
                 cpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgve 
                   
               
               
                   
                 vhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskak 
                   
               
               
                   
                 gqprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennyktt 
                   
               
               
                   
                 ppvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Divltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn 
                 SEQ ID 
               
               
                   
                 vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtva 
                 NO: 407 
               
               
                   
                 apsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds 
                   
               
               
                   
                 kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 qvqlvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaq 
                 SEQ ID 
               
               
                   
                 ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy 
                 NO: 408 
               
               
                   
                 alspfdywgqgtlvtvssdkthtrahlyqsgtamkkpgasvrvscqtsgytft 
                   
               
               
                   
                 ahilfwfrqapgrglewvgwikpqygavnfgggfrdrytltrdvyreiaym 
                   
               
               
                   
                 dirglkpddtavyycardrsygdsswaldawgqgttvvvsadkthtastkgp 
                   
               
               
                   
                 svfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss 
                   
               
               
                   
                 glyslssvvtypssslgtktytcnvdhkpsntkvdkrveskygppcppcpap 
                   
               
               
                   
                 eflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgve 
                   
               
               
                   
                 vhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiekt 
                   
               
               
                   
                 iskakgqprepqvctlppsqeemtknqvslscavkgfypsdiavewesng 
                   
               
               
                   
                 qpennykttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhy 
                   
               
               
                   
                 tqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg 
                 SEQ ID 
               
               
                   
                 vpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikdkthtdivmtqtpls 
                 NO: 409 
               
               
                   
                 lsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvsnrfsgvpdrfs 
                   
               
               
                   
                 gsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkthtrtvaapsvfi 
                   
               
               
                   
                 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdsty 
                   
               
               
                   
                 slsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 45 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagc 
                 SEQ ID 
               
               
                   
                 ctgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcc 
                 NO: 410 
               
               
                   
                 agccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcacc 
                   
               
               
                   
                 aactacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaac 
                   
               
               
                   
                 caggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcg 
                   
               
               
                   
                 ccagagacaagggctacagctactactacagcatggactactggggccagggcacca 
                   
               
               
                   
                 ccgtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgc 
                   
               
               
                   
                 agcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttc 
                   
               
               
                   
                 ccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacaccttt 
                   
               
               
                   
                 ccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgccca 
                   
               
               
                   
                 gcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaaca 
                   
               
               
                   
                 ccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagc 
                   
               
               
                   
                 ccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccct 
                   
               
               
                   
                 gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagat 
                   
               
               
                   
                 cccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagacc 
                   
               
               
                   
                 aagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtg 
                   
               
               
                   
                 ctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggc 
                   
               
               
                   
                 ctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcc 
                   
               
               
                   
                 tcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgt 
                   
               
               
                   
                 ggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacgg 
                   
               
               
                   
                 ccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt 
                   
               
               
                   
                 cttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctct 
                   
               
               
                   
                 gtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca 
                 SEQ ID 
               
               
                   
                 ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg 
                 NO: 411 
               
               
                   
                 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg 
                   
               
               
                   
                 gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga 
                   
               
               
                   
                 ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga 
                   
               
               
                   
                 aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccg 
                   
               
               
                   
                 ctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctct 
                   
               
               
                   
                 gtcgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtgg 
                   
               
               
                   
                 acaatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaa 
                   
               
               
                   
                 ggactccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaa 
                   
               
               
                   
                 gcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaa 
                   
               
               
                   
                 gagcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgag 
                 SEQ ID 
               
               
                   
                 actgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgc 
                 NO: 412 
               
               
                   
                 caggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacag 
                   
               
               
                   
                 ctacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacga 
                   
               
               
                   
                 cagcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccg 
                   
               
               
                   
                 tgtactactgtcggggcgtgtactatgccctgagccccttcgattactggggccaggga 
                   
               
               
                   
                 accctcgtgaccgtgtctagtgacaaaacccataccagagcccacctggtgcagtctgg 
                   
               
               
                   
                 caccgccatgaagaaaccaggcgcctctgtgcgggtgtcctgtcagacaagcggcta 
                   
               
               
                   
                 caccttcaccgcccacatcctgttctggttccggcaggcccctggcagaggactggaat 
                   
               
               
                   
                 gggtgggatggatcaagccccagtatggcgccgtgaacttcggcggaggcttccggg 
                   
               
               
                   
                 atagagtgaccctgacccgggacgtgtaccgcgagatcgcctacatggacatccggg 
                   
               
               
                   
                 gcctgaagcccgatgacaccgccgtgtactactgcgccagagacagaagctacggcg 
                   
               
               
                   
                 acagcagctgggctctggatgcttggggccagggcacaaccgtggtggtgtctgccg 
                   
               
               
                   
                 ataagacccacaccgccagcacaaagggcccatcggtgttccctctggccccttgcag 
                   
               
               
                   
                 cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc 
                   
               
               
                   
                 gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc 
                   
               
               
                   
                 agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc 
                   
               
               
                   
                 agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc 
                   
               
               
                   
                 aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc 
                   
               
               
                   
                 ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctg 
                   
               
               
                   
                 atgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatc 
                   
               
               
                   
                 ccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagacca 
                   
               
               
                   
                 agcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgct 
                   
               
               
                   
                 gcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcct 
                   
               
               
                   
                 gcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctc 
                   
               
               
                   
                 aagtgtgtaccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgag 
                   
               
               
                   
                 ctgtgccgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggc 
                   
               
               
                   
                 cagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct 
                   
               
               
                   
                 tcctggtgtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttca 
                   
               
               
                   
                 gctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctg 
                   
               
               
                   
                 tccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagtga 
                 SEQ ID 
               
               
                   
                 ccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagcacaa 
                 NO: 413 
               
               
                   
                 gcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagatggcgt 
                   
               
               
                   
                 gcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcagcgatc 
                   
               
               
                   
                 tgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcagaggc 
                   
               
               
                   
                 agcagactgcacatcaaggacaaaacccataccgacatcgtgatgacccagaccccc 
                   
               
               
                   
                 ctgagcctgagcgtgacacctggacagcctgccagcatcagctgcaagagcagccag 
                   
               
               
                   
                 agcctggtgcacaacaacgccaacacctacctgagctggtatctgcagaagcccggc 
                   
               
               
                   
                 cagagcccccagtccctgatctacaaggtgtccaacagattcagcggcgtgcccgaca 
                   
               
               
                   
                 gattctccggcagcggctctggcaccgacttcaccctgaagatcagccgggtggaagc 
                   
               
               
                   
                 cgaggacgtgggcgtgtactattgtggccagggcacccagtaccccttcacctttggca 
                   
               
               
                   
                 gcggcaccaaggtggaaatcaaggataagacccatacccgtacggtggccgctccca 
                   
               
               
                   
                 gcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtg 
                   
               
               
                   
                 tgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaac 
                   
               
               
                   
                 gccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggact 
                   
               
               
                   
                 ccacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcaca 
                   
               
               
                   
                 aggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt 
                   
               
               
                   
                 caaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 46 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypg 
                 SEQ ID 
               
               
                   
                 nvntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvvvgk 
                 NO: 414 
               
               
                   
                 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht 
                   
               
               
                   
                 fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc 
                   
               
               
                   
                 papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev 
                   
               
               
                   
                 hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg 
                   
               
               
                   
                 qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp 
                   
               
               
                   
                 pvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht 
                 SEQ ID 
               
               
                   
                 gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi 
                 NO: 415 
               
               
                   
                 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdsty 
                   
               
               
                   
                 slsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmg 
                 SEQ ID 
               
               
                   
                 wishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskh 
                 NO: 416 
               
               
                   
                 rlrdyalydddgalnwavdvdylsnlefwgqgtavtvsssqvqlvesgggv 
                   
               
               
                   
                 vqpgrslrlscaasgftftkawmhwvrqapgkqlewvaqikdksnsyatyy 
                   
               
               
                   
                 adsvkgrftisrddskntlylqmnslraedtavyycrgvyyalspfdywgqg 
                   
               
               
                   
                 tlvtvssrtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgalt 
                   
               
               
                   
                 sgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrvesk 
                   
               
               
                   
                 ygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpe 
                   
               
               
                   
                 vqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykck 
                   
               
               
                   
                 vsnkglpssiektiskakgqprepqvctlppsqeemtknqvslscavkgfyp 
                   
               
               
                   
                 sdiavewesngqpennykttppvldsdgsfflvskltvdksrwqegnvfscs 
                   
               
               
                   
                 vmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs 
                 SEQ ID 
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp 
                 NO: 417 
               
               
                   
                 kaapdfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliyl 
                   
               
               
                   
                 assrasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikt 
                   
               
               
                   
                 kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq 
                   
               
               
                   
                 esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 46 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaag 
                 SEQ ID 
               
               
                   
                 gtgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgcca 
                 NO: 418 
               
               
                   
                 ggcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacac 
                   
               
               
                   
                 caactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcag 
                   
               
               
                   
                 caccgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactg 
                   
               
               
                   
                 cacccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccac 
                   
               
               
                   
                 cgtgacagtgtctagcgcgtcgaccaagggcccctcggtgaccctctggccccttgca 
                   
               
               
                   
                 gcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcc 
                   
               
               
                   
                 cgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttc 
                   
               
               
                   
                 cagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccag 
                   
               
               
                   
                 cagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacac 
                   
               
               
                   
                 caaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcc 
                   
               
               
                   
                 cctgaatactgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccct 
                   
               
               
                   
                 gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagat 
                   
               
               
                   
                 cccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagacc 
                   
               
               
                   
                 aagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtg 
                   
               
               
                   
                 ctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggc 
                   
               
               
                   
                 ctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcc 
                   
               
               
                   
                 tcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgt 
                   
               
               
                   
                 ggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacgg 
                   
               
               
                   
                 ccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt 
                   
               
               
                   
                 cacctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttc 
                   
               
               
                   
                 agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctct 
                   
               
               
                   
                 gtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagtg 
                 SEQ ID 
               
               
                   
                 accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa 
                 NO: 419 
               
               
                   
                 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt 
                   
               
               
                   
                 gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc 
                   
               
               
                   
                 tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac 
                   
               
               
                   
                 ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc 
                   
               
               
                   
                 atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct 
                   
               
               
                   
                 gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca 
                   
               
               
                   
                 gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac 
                   
               
               
                   
                 agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgta 
                   
               
               
                   
                 cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccg 
                   
               
               
                   
                 gggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaa 
                 SEQ ID 
               
               
                   
                 ggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgc 
                 NO: 420 
               
               
                   
                 agcgtgccaggacagggactgcagtggatgggctggatcagccacgagggcgacaa 
                   
               
               
                   
                 gaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggacagaagcac 
                   
               
               
                   
                 caacaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactact 
                   
               
               
                   
                 gcgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacggc 
                   
               
               
                   
                 gccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggccagg 
                   
               
               
                   
                 gcacagccgtgaccgtgtcatcttctcaggtgcagctggtggaatctggcggcggagt 
                   
               
               
                   
                 ggtgcagcctggcagaagcctgagactgagctgtgccgccagcggcttcaccacacc 
                   
               
               
                   
                 aaggcctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggc 
                   
               
               
                   
                 ccagatcaaggacaagagcaacagctacgccacctactacgccgacagcgtgaagg 
                   
               
               
                   
                 gccggttcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaaca 
                   
               
               
                   
                 gcctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgag 
                   
               
               
                   
                 ccccttcgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcga 
                   
               
               
                   
                 ccaagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctac 
                   
               
               
                   
                 agccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctgg 
                   
               
               
                   
                 aactctggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcg 
                   
               
               
                   
                 gcctgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaaga 
                   
               
               
                   
                 cctacacctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtg 
                   
               
               
                   
                 gaatctaagtacggccctccctgccctccttgcccagcccctgaatttctgggcggacc 
                   
               
               
                   
                 ctccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccccc 
                   
               
               
                   
                 gaagtgacctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattg 
                   
               
               
                   
                 gtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagt 
                   
               
               
                   
                 tcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaa 
                   
               
               
                   
                 cggcaaagagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaa 
                   
               
               
                   
                 aaccatcagcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccc 
                   
               
               
                   
                 tagccaggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttc 
                   
               
               
                   
                 taccccagcgacattgccgtggaatgggagagcaacggccagcccgagaacaacta 
                   
               
               
                   
                 caagaccaccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctga 
                   
               
               
                   
                 ccgtggacaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacg 
                   
               
               
                   
                 aggccctgcacaaccactacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg 
                 NO: 421 
               
               
                   
                 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca 
                   
               
               
                   
                 acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac 
                   
               
               
                   
                 cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg 
                   
               
               
                   
                 cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagcc 
                   
               
               
                   
                 caaggccgcccccgacttcgtgctgacccagagccctcacagcctgagcgtgacacc 
                   
               
               
                   
                 tggcgagagcgccagcatcagctgcaagagcagccactccctgatccacggcgacc 
                   
               
               
                   
                 ggaacaactacctggcttggtacgtgcagaagcccggcagatccccccagctgctgat 
                   
               
               
                   
                 ctacctggccagcagcagagccagcggcgtgcccgatagattttctggcagcggcag 
                   
               
               
                   
                 cgacaaggacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcaccta 
                   
               
               
                   
                 ctactgtatgcagggcagagagagcccctggacctttggccagggcaccaaggtgga 
                   
               
               
                   
                 catcaagaccaagggccccagccgtacggtggccgctcccagcgtgttcatcttccca 
                   
               
               
                   
                 cctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaactt 
                   
               
               
                   
                 ctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggca 
                   
               
               
                   
                 acagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagc 
                   
               
               
                   
                 agcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcga 
                   
               
               
                   
                 agtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtg 
                   
               
               
                   
                 t 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 47 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypgn 
                 SEQ ID 
               
               
                   
                 vntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgkg 
                 NO: 422 
               
               
                   
                 ttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtf 
                   
               
               
                   
                 pavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcp 
                   
               
               
                   
                 apeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevh 
                   
               
               
                   
                 naktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgq 
                   
               
               
                   
                 prepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttpp 
                   
               
               
                   
                 vldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht 
                 SEQ ID 
               
               
                   
                 gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi 
                 NO: 423 
               
               
                   
                 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmg 
                 SEQ ID 
               
               
                   
                 wishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskh 
                 NO: 424 
               
               
                   
                 rlrdyalydddgalnwavdvdylsnlefwgqgtavtvssdkthtqvqlvesg 
                   
               
               
                   
                 ggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaqikdksnsy 
                   
               
               
                   
                 atyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyyalspfdyw 
                   
               
               
                   
                 gqgtlvtvssdkthtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvs 
                   
               
               
                   
                 wnsgaltsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkv 
                   
               
               
                   
                 dkrveskygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvd 
                   
               
               
                   
                 vsqedpevqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwln 
                   
               
               
                   
                 gkeykckvsnkglpssiektiskakgqprepqvctlppsqeemtknqvslsc 
                   
               
               
                   
                 avkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrwq 
                   
               
               
                   
                 egnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs 
                 SEQ ID 
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkth 
                 NO: 425 
               
               
                   
                 tdfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr 
                   
               
               
                   
                 asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkth 
                   
               
               
                   
                 trtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt 
                   
               
               
                   
                 eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 47 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg 
                 SEQ ID 
               
               
                   
                 tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag 
                 NO: 426 
               
               
                   
                 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc 
                   
               
               
                   
                 aactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcagc 
                   
               
               
                   
                 accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc 
                   
               
               
                   
                 acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc 
                   
               
               
                   
                 gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag 
                   
               
               
                   
                 cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc 
                   
               
               
                   
                 gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc 
                   
               
               
                   
                 agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc 
                   
               
               
                   
                 agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc 
                   
               
               
                   
                 aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc 
                   
               
               
                   
                 ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga 
                   
               
               
                   
                 tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc 
                   
               
               
                   
                 cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa 
                   
               
               
                   
                 gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg 
                   
               
               
                   
                 caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg 
                   
               
               
                   
                 cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca 
                   
               
               
                   
                 agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt 
                   
               
               
                   
                 gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc 
                   
               
               
                   
                 ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc 
                   
               
               
                   
                 ctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagtg 
                 SEQ ID 
               
               
                   
                 accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa 
                 NO: 427 
               
               
                   
                 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt 
                   
               
               
                   
                 gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc 
                   
               
               
                   
                 tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac 
                   
               
               
                   
                 ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc 
                   
               
               
                   
                 atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct 
                   
               
               
                   
                 gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca 
                   
               
               
                   
                 gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac 
                   
               
               
                   
                 agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgtac 
                   
               
               
                   
                 gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg 
                   
               
               
                   
                 ggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaag 
                 SEQ ID 
               
               
                   
                 gtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgca 
                 NO: 428 
               
               
                   
                 gcgtgccaggacagggactgcagtggatgggctggatcagccacgagggcgacaag 
                   
               
               
                   
                 aaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggacagaagcacc 
                   
               
               
                   
                 aacaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactactg 
                   
               
               
                   
                 cgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacggcg 
                   
               
               
                   
                 ccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggccaggg 
                   
               
               
                   
                 cacagccgtgaccgtgtcatctgacaaaacccatacccaggtgcagctggtggaatctg 
                   
               
               
                   
                 gcggcggagtggtgcagcctggcagaagcctgagactgagctgtgccgccagcggc 
                   
               
               
                   
                 ttcaccttcaccaaggcctggatgcactgggtgcgccaggcccctggaaagcagctgg 
                   
               
               
                   
                 aatgggtggcccagatcaaggacaagagcaacagctacgccacctactacgccgaca 
                   
               
               
                   
                 gcgtgaagggccggttcaccatcagccgggacgacagcaagaacaccctgtacctgc 
                   
               
               
                   
                 agatgaacagcctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtacta 
                   
               
               
                   
                 tgccctgagccccttcgattactggggccagggaaccctcgtgaccgtgtctagtgataa 
                   
               
               
                   
                 gacccacaccgcttcgaccaagggcccatcggtgttccctctggccccttgcagcaga 
                   
               
               
                   
                 agcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccgagc 
                   
               
               
                   
                 ccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccagcc 
                   
               
               
                   
                 gtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagcagca 
                   
               
               
                   
                 gcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaagg 
                   
               
               
                   
                 tggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccctgaa 
                   
               
               
                   
                 tttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctgatgatc 
                   
               
               
                   
                 agccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcccgag 
                   
               
               
                   
                 gtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccca 
                   
               
               
                   
                 gagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcacca 
                   
               
               
                   
                 ggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgcccag 
                   
               
               
                   
                 ctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctcaagtgtg 
                   
               
               
                   
                 taccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagctgtgcc 
                   
               
               
                   
                 gtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggccagccc 
                   
               
               
                   
                 gagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcctggt 
                   
               
               
                   
                 gtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagctgctc 
                   
               
               
                   
                 cgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccctgg 
                   
               
               
                   
                 gcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcca 
                 SEQ ID 
               
               
                   
                 gcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctga 
                 NO: 429 
               
               
                   
                 gctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtccaa 
                   
               
               
                   
                 cagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcacc 
                   
               
               
                   
                 ctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccagggc 
                   
               
               
                   
                 acccagtaccccttcacctttggcagcggcaccaaggtggaaatcaaggacaaaaccc 
                   
               
               
                   
                 ataccgacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagag 
                   
               
               
                   
                 cgccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                   
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggcca 
                   
               
               
                   
                 gcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggact 
                   
               
               
                   
                 tcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgca 
                   
               
               
                   
                 gggcagagagagcccctggacctttggccagggcaccaaggtggacatcaaggataa 
                   
               
               
                   
                 gacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagc 
                   
               
               
                   
                 agctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgag 
                   
               
               
                   
                 gccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaa 
                   
               
               
                   
                 gcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgaca 
                   
               
               
                   
                 ctgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccag 
                   
               
               
                   
                 ggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 48 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypgn 
                 SEQ ID 
               
               
                   
                 vntnyaqkfqgradtvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgkg 
                 NO: 430 
               
               
                   
                 ttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtf 
                   
               
               
                   
                 pavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcp 
                   
               
               
                   
                 apeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevh 
                   
               
               
                   
                 naktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgq 
                   
               
               
                   
                 prepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttpp 
                   
               
               
                   
                 vldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht 
                 SEQ ID 
               
               
                   
                 gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi 
                 NO: 431 
               
               
                   
                 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvqlvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaq 
                 SEQ ID 
               
               
                   
                 ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy 
                 NO: 432 
               
               
                   
                 alspfdywgqgtlvtvsssqvhltqsgpevrkpgtsvkvsckapgntlktydl 
                   
               
               
                   
                 hwvrsvpgqglqwmgwishegdkkviverfkakvtidwdrstntaylqls 
                   
               
               
                   
                 gltsgdtavyycakgskhrlrdyalydddgalnwavdvdylsnlefwgqgt 
                   
               
               
                   
                 avtvssrtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgalt 
                   
               
               
                   
                 sgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrvesk 
                   
               
               
                   
                 ygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpe 
                   
               
               
                   
                 vqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykck 
                   
               
               
                   
                 vsnkglpssiektiskakgqprepqvctlppsqeemtknqvslscavkgfyp 
                   
               
               
                   
                 sdiavewesngqpennykttppvldsdgsfflvskltvdksrwqegnvfscs 
                   
               
               
                   
                 vmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr 
                 SEQ ID 
               
               
                   
                 asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikgqp 
                 NO: 433 
               
               
                   
                 kaapdivmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliy 
                   
               
               
                   
                 kvsnrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikt 
                   
               
               
                   
                 kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq 
                   
               
               
                   
                 esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 48 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg 
                 SEQ ID 
               
               
                   
                 tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag 
                 NO: 434 
               
               
                   
                 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc 
                   
               
               
                   
                 aactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcagc 
                   
               
               
                   
                 accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc 
                   
               
               
                   
                 acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc 
                   
               
               
                   
                 gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag 
                   
               
               
                   
                 cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc 
                   
               
               
                   
                 gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc 
                   
               
               
                   
                 agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc 
                   
               
               
                   
                 agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc 
                   
               
               
                   
                 aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc 
                   
               
               
                   
                 ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga 
                   
               
               
                   
                 tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc 
                   
               
               
                   
                 cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa 
                   
               
               
                   
                 gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg 
                   
               
               
                   
                 caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg 
                   
               
               
                   
                 cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca 
                   
               
               
                   
                 agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt 
                   
               
               
                   
                 gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc 
                   
               
               
                   
                 ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc 
                   
               
               
                   
                 ctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagtg 
                 SEQ ID 
               
               
                   
                 accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa 
                 NO: 435 
               
               
                   
                 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt 
                   
               
               
                   
                 gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc 
                   
               
               
                   
                 tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac 
                   
               
               
                   
                 ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc 
                   
               
               
                   
                 atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct 
                   
               
               
                   
                 gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca 
                   
               
               
                   
                 gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac 
                   
               
               
                   
                 agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgtac 
                   
               
               
                   
                 gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg 
                   
               
               
                   
                 ggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgaga 
                 SEQ ID 
               
               
                   
                 ctgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgcc 
                 NO: 436 
               
               
                   
                 aggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacagc 
                   
               
               
                   
                 tacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacgac 
                   
               
               
                   
                 agcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccgtg 
                   
               
               
                   
                 tactactgtcggggcgtgtactatgccctgagccccttcgattactggggccagggaac 
                   
               
               
                   
                 cctcgtgaccgtgtctagtagccaggtgcacctgacacagagcggacccgaagtgcg 
                   
               
               
                   
                 gaagcctggcacctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacc 
                   
               
               
                   
                 tacgacctgcactgggtgcgcagcgtgccaggacagggactgcagtggatgggctgg 
                   
               
               
                   
                 atcagccacgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgacc 
                   
               
               
                   
                 atcgactgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctg 
                   
               
               
                   
                 gcgataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacg 
                   
               
               
                   
                 ccctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaa 
                   
               
               
                   
                 cctggaattctggggccagggcacagccgtgaccgtgtcatctcggaccgccagcaca 
                   
               
               
                   
                 aagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacag 
                   
               
               
                   
                 ccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaac 
                   
               
               
                   
                 tctggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcc 
                   
               
               
                   
                 tgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagaccta 
                   
               
               
                   
                 cacctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatc 
                   
               
               
                   
                 taagtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgt 
                   
               
               
                   
                 gacctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtg 
                   
               
               
                   
                 acctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgt 
                   
               
               
                   
                 ggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaaca 
                   
               
               
                   
                 gcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaa 
                   
               
               
                   
                 agagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc 
                   
               
               
                   
                 agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagccag 
                   
               
               
                   
                 gaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccca 
                   
               
               
                   
                 gcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagacc 
                   
               
               
                   
                 accccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgga 
                   
               
               
                   
                 caagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccct 
                   
               
               
                   
                 gcacaaccactacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccactccctgatccacggcgaccggaacaactacctg 
                 NO: 437 
               
               
                   
                 gcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggccagca 
                   
               
               
                   
                 gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggacttca 
                   
               
               
                   
                 ccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgcagg 
                   
               
               
                   
                 gcagagagagcccctggacctttggccagggcaccaaggtggacatcaagggccag 
                   
               
               
                   
                 cccaaggccgcccccgacatcgtgatgacccagacccccctgagcctgagcgtgaca 
                   
               
               
                   
                 cctggacagcctgccagcatcagctgcaagagcagccagagcctggtgcacaacaac 
                   
               
               
                   
                 gccaacacctacctgagctggtatctgcagaagcccggccagagcccccagtccctga 
                   
               
               
                   
                 tctacaaggtgtccaacagattcagcggcgtgcccgacagattctccggcagcggctct 
                   
               
               
                   
                 ggcaccgacttcaccctgaagatcagccgggtggaagccgaggacgtgggcgtgtac 
                   
               
               
                   
                 tattgtggccagggcacccagtaccccttcacctttggcagcggcaccaaggtggaaat 
                   
               
               
                   
                 caagaccaagggccccagccgtacggtggccgctcccagcgtgttcatcttcccacct 
                   
               
               
                   
                 agcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttcta 
                   
               
               
                   
                 cccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca 
                   
               
               
                   
                 gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagc 
                   
               
               
                   
                 accctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtg 
                   
               
               
                   
                 acccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 49 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypgn 
                 SEQ ID 
               
               
                   
                 vntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgkg 
                 NO: 438 
               
               
                   
                 ttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtf 
                   
               
               
                   
                 pavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcp 
                   
               
               
                   
                 apeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevh 
                   
               
               
                   
                 naktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgq 
                   
               
               
                   
                 prepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttpp 
                   
               
               
                   
                 vldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht 
                 SEQ ID 
               
               
                   
                 gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi 
                 NO: 439 
               
               
                   
                 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys 
                   
               
               
                   
                 lsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvqlvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaq 
                 SEQ ID 
               
               
                   
                 ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy 
                 NO: 440 
               
               
                   
                 alspfdywgqgtlvtvssdkthtqvhltqsgpevrkpgtsykysckapgntlk 
                   
               
               
                   
                 tydlhwyrsvpgqglqwmgwishegdkkviverfkakvtidwdrstntay 
                   
               
               
                   
                 lqlsgltsgdtavyycakgskhrlrdyalydddgalnwavdvdylsnlefwg 
                   
               
               
                   
                 qgtavtvssdkthtastkgpsvfplapcsrstsestaalgclykdyfpepvtvs 
                   
               
               
                   
                 wnsgaltsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkv 
                   
               
               
                   
                 dkrveskygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvd 
                   
               
               
                   
                 vsqedpevqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwln 
                   
               
               
                   
                 gkeykckvsnkglpssiektiskakgqprepqvctlppsqeemtknqvslsc 
                   
               
               
                   
                 avkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrwq 
                   
               
               
                   
                 egnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr 
                 SEQ ID 
               
               
                   
                 asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkth 
                 NO: 441 
               
               
                   
                 tdivmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs 
                   
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkth 
                   
               
               
                   
                 trtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt 
                   
               
               
                   
                 eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 49 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg 
                 SEQ ID 
               
               
                   
                 tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag 
                 NO: 442 
               
               
                   
                 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc 
                   
               
               
                   
                 aactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcagc 
                   
               
               
                   
                 accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc 
                   
               
               
                   
                 acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc 
                   
               
               
                   
                 gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag 
                   
               
               
                   
                 cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc 
                   
               
               
                   
                 gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc 
                   
               
               
                   
                 agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc 
                   
               
               
                   
                 agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc 
                   
               
               
                   
                 aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc 
                   
               
               
                   
                 ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga 
                   
               
               
                   
                 tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc 
                   
               
               
                   
                 cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa 
                   
               
               
                   
                 gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg 
                   
               
               
                   
                 caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg 
                   
               
               
                   
                 cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca 
                   
               
               
                   
                 agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt 
                   
               
               
                   
                 gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc 
                   
               
               
                   
                 ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc 
                   
               
               
                   
                 ctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagtg 
                 SEQ ID 
               
               
                   
                 accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa 
                 NO: 443 
               
               
                   
                 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt 
                   
               
               
                   
                 gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc 
                   
               
               
                   
                 tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac 
                   
               
               
                   
                 ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc 
                   
               
               
                   
                 atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct 
                   
               
               
                   
                 gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca 
                   
               
               
                   
                 gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac 
                   
               
               
                   
                 agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgtac 
                   
               
               
                   
                 gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg 
                   
               
               
                   
                 ggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgaga 
                 SEQ ID 
               
               
                   
                 ctgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgcc 
                 NO: 444 
               
               
                   
                 aggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacagc 
                   
               
               
                   
                 tacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacgac 
                   
               
               
                   
                 agcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccgtg 
                   
               
               
                   
                 tactactgtcggggcgtgtactatgccctgagccccttcgattactggggccagggaac 
                   
               
               
                   
                 cctcgtgaccgtgtctagtgacaaaacccatacccaggtgcacctgacacagagcgga 
                   
               
               
                   
                 cccgaagtgcggaagcctggcacctctgtgaaggtgtcctgcaaggcccctggcaaca 
                   
               
               
                   
                 ccctgaaaacctacgacctgcactgggtgcgcagcgtgccaggacagggactgcagt 
                   
               
               
                   
                 ggatgggctggatcagccacgagggcgacaagaaagtgatcgtggaacggttcaagg 
                   
               
               
                   
                 ccaaagtgaccatcgactgggacagaagcaccaacaccgcctacctgcagctgagcg 
                   
               
               
                   
                 gcctgacctctggcgataccgccgtgtactactgcgccaagggcagcaagcaccggct 
                   
               
               
                   
                 gagagactacgccctgtacgacgatgacggcgccctgaactgggccgtggatgtgga 
                   
               
               
                   
                 ctacctgagcaacctggaattctggggccagggcacagccgtgaccgtgtcatctgata 
                   
               
               
                   
                 agacccacaccgccagcacaaagggcccatcggtgttccctctggccccttgcagcag 
                   
               
               
                   
                 aagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccgag 
                   
               
               
                   
                 cccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccagc 
                   
               
               
                   
                 cgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagcagc 
                   
               
               
                   
                 agcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaag 
                   
               
               
                   
                 gtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccctga 
                   
               
               
                   
                 atttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctgatgat 
                   
               
               
                   
                 cagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcccga 
                   
               
               
                   
                 ggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcc 
                   
               
               
                   
                 cagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcac 
                   
               
               
                   
                 caggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgccc 
                   
               
               
                   
                 agctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctcaagt 
                   
               
               
                   
                 gtgtaccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagctgt 
                   
               
               
                   
                 gccgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggccag 
                   
               
               
                   
                 cccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct 
                   
               
               
                   
                 ggtgtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagctg 
                   
               
               
                   
                 ctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccct 
                   
               
               
                   
                 gggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccactccctgatccacggcgaccggaacaactacctg 
                 NO: 445 
               
               
                   
                 gcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggccagca 
                   
               
               
                   
                 gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggacttca 
                   
               
               
                   
                 ccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgcagg 
                   
               
               
                   
                 gcagagagagcccctggacctttggccagggcaccaaggtggacatcaaggacaaa 
                   
               
               
                   
                 acccataccgacatcgtgatgacccagacccccctgagcctgagcgtgacacctggac 
                   
               
               
                   
                 agcctgccagcatcagctgcaagagcagccagagcctggtgcacaacaacgccaaca 
                   
               
               
                   
                 cctacctgagctggtatctgcagaagcccggccagagcccccagtccctgatctacaa 
                   
               
               
                   
                 ggtgtccaacagattcagcggcgtgcccgacagattctccggcagcggctctggcacc 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtg 
                   
               
               
                   
                 gccagggcacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagg 
                   
               
               
                   
                 ataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcgac 
                   
               
               
                   
                 gagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccg 
                   
               
               
                   
                 cgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccag 
                   
               
               
                   
                 gaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccct 
                   
               
               
                   
                 gacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgaccca 
                   
               
               
                   
                 ccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 50 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwaggg 
                 SEQ ID 
               
               
                   
                 tnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywgq 
                 NO: 446 
               
               
                   
                 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht 
                   
               
               
                   
                 fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc 
                   
               
               
                   
                 papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev 
                   
               
               
                   
                 hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg 
                   
               
               
                   
                 qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp 
                   
               
               
                   
                 pvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Divltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn 
                 SEQ ID 
               
               
                   
                 vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtvaa 
                 NO: 447 
               
               
                   
                 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk 
                   
               
               
                   
                 dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmg 
                 SEQ ID 
               
               
                   
                 wishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskh 
                 NO: 448 
               
               
                   
                 rlrdyalydddgalnwavdvdylsnlefwgqgtavtvsssqvqlvesgggv 
                   
               
               
                   
                 vqpgrslrlscaasgftftkawmhwvrqapgkqlewvaqikdksnsyatyy 
                   
               
               
                   
                 adsvkgrftisrddskntlylqmnslraedtavyycrgvyyalspfdywgqgt 
                   
               
               
                   
                 lvtvssrtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgalt 
                   
               
               
                   
                 sgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrvesk 
                   
               
               
                   
                 ygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpe 
                   
               
               
                   
                 vqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykck 
                   
               
               
                   
                 vsnkglpssiektiskakgqprepqvctlppsqeemtknqvslscavkgfyp 
                   
               
               
                   
                 sdiavewesngqpennykttppvldsdgsfflvskltvdksrwqegnvfscs 
                   
               
               
                   
                 vmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs 
                 SEQ ID 
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp 
                 NO: 449 
               
               
                   
                 kaapdfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliyl 
                   
               
               
                   
                 assrasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikt 
                   
               
               
                   
                 kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq 
                   
               
               
                   
                 esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 50 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagcc 
                 SEQ ID 
               
               
                   
                 tgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcca 
                 NO: 450 
               
               
                   
                 gccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcaccaa 
                   
               
               
                   
                 ctacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaacca 
                   
               
               
                   
                 ggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcgcc 
                   
               
               
                   
                 agagacaagggctacagctactactacagcatggactactggggccagggcaccacc 
                   
               
               
                   
                 gtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgcag 
                   
               
               
                   
                 cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc 
                   
               
               
                   
                 gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc 
                   
               
               
                   
                 agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc 
                   
               
               
                   
                 agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc 
                   
               
               
                   
                 aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc 
                   
               
               
                   
                 ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga 
                   
               
               
                   
                 tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc 
                   
               
               
                   
                 cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa 
                   
               
               
                   
                 gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg 
                   
               
               
                   
                 caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg 
                   
               
               
                   
                 cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca 
                   
               
               
                   
                 agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt 
                   
               
               
                   
                 gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc 
                   
               
               
                   
                 ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc 
                   
               
               
                   
                 ctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca 
                 SEQ ID 
               
               
                   
                 ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg 
                 NO: 451 
               
               
                   
                 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg 
                   
               
               
                   
                 gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga 
                   
               
               
                   
                 ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga 
                   
               
               
                   
                 aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccgc 
                   
               
               
                   
                 tcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgt 
                   
               
               
                   
                 cgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtggac 
                   
               
               
                   
                 aatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaagg 
                   
               
               
                   
                 actccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaagc 
                   
               
               
                   
                 acaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga 
                   
               
               
                   
                 gcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaag 
                 SEQ ID 
               
               
                   
                 gtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgca 
                 NO: 452 
               
               
                   
                 gcgtgccaggacagggactgcagtggatgggctggatcagccacgagggcgacaag 
                   
               
               
                   
                 aaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggacagaagcacc 
                   
               
               
                   
                 aacaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactactg 
                   
               
               
                   
                 cgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacggcg 
                   
               
               
                   
                 ccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggccaggg 
                   
               
               
                   
                 cacagccgtgaccgtgtcatcttctcaggtgcagctggtggaatctggcggcggagtg 
                   
               
               
                   
                 gtgcagcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcacca 
                   
               
               
                   
                 aggcctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggccc 
                   
               
               
                   
                 agatcaaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggc 
                   
               
               
                   
                 cggttcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagc 
                   
               
               
                   
                 ctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcc 
                   
               
               
                   
                 ccttcgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcgacc 
                   
               
               
                   
                 aagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacag 
                   
               
               
                   
                 ccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaac 
                   
               
               
                   
                 tctggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcc 
                   
               
               
                   
                 tgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagaccta 
                   
               
               
                   
                 cacctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatc 
                   
               
               
                   
                 taagtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgt 
                   
               
               
                   
                 gttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtg 
                   
               
               
                   
                 acctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgt 
                   
               
               
                   
                 ggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaaca 
                   
               
               
                   
                 gcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaa 
                   
               
               
                   
                 agagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc 
                   
               
               
                   
                 agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagccag 
                   
               
               
                   
                 gaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccca 
                   
               
               
                   
                 gcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagacc 
                   
               
               
                   
                 accccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgga 
                   
               
               
                   
                 caagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccct 
                   
               
               
                   
                 gcacaaccactacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcca 
                 SEQ ID 
               
               
                   
                 gcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctga 
                 NO: 453 
               
               
                   
                 gctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtccaa 
                   
               
               
                   
                 cagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcacc 
                   
               
               
                   
                 ctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccagggc 
                   
               
               
                   
                 acccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagccca 
                   
               
               
                   
                 aggccgcccccgacttcgtgctgacccagagccctcacagcctgagcgtgacacctg 
                   
               
               
                   
                 gcgagagcgccagcatcagctgcaagagcagccactccctgatccacggcgaccgg 
                   
               
               
                   
                 aacaactacctggcttggtacgtgcagaagcccggcagatccccccagctgctgatcta 
                   
               
               
                   
                 cctggccagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcga 
                   
               
               
                   
                 caaggacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctacta 
                   
               
               
                   
                 ctgtatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacat 
                   
               
               
                   
                 caagaccaagggccccagccgtacggtggccgctcccagcgtgttcatcttcccacct 
                   
               
               
                   
                 agcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttcta 
                   
               
               
                   
                 cccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca 
                   
               
               
                   
                 gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagc 
                   
               
               
                   
                 accctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtg 
                   
               
               
                   
                 acccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 51 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwaggg 
                 SEQ ID 
               
               
                   
                 tnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywgq 
                 NO: 454 
               
               
                   
                 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht 
                   
               
               
                   
                 fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc 
                   
               
               
                   
                 papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev 
                   
               
               
                   
                 hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg 
                   
               
               
                   
                 qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp 
                   
               
               
                   
                 pvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Divltqspaslayspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn 
                 SEQ ID 
               
               
                   
                 vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtvaa 
                 NO: 455 
               
               
                   
                 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk 
                   
               
               
                   
                 dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmg 
                 SEQ ID 
               
               
                   
                 wishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskh 
                 NO: 456 
               
               
                   
                 rlrdyalydddgalnwavdvdylsnlefwgqgtavtvssdkthtqvqlvesg 
                   
               
               
                   
                 ggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaqikdksnsy 
                   
               
               
                   
                 atyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyyalspfdyw 
                   
               
               
                   
                 gqgtlvtvssdkthtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvs 
                   
               
               
                   
                 wnsgaltsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkv 
                   
               
               
                   
                 dkrveskygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvd 
                   
               
               
                   
                 vsqedpevqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwln 
                   
               
               
                   
                 gkeykckvsnkglpssiektiskakgqprepqvctlppsqeemtknqvslsc 
                   
               
               
                   
                 avkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrwq 
                   
               
               
                   
                 egnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs 
                 SEQ ID 
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkth 
                 NO: 457 
               
               
                   
                 tdfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr 
                   
               
               
                   
                 asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkth 
                   
               
               
                   
                 trtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt 
                   
               
               
                   
                 eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 51 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagcc 
                 SEQ ID 
               
               
                   
                 tgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcca 
                 NO: 458 
               
               
                   
                 gccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcaccaa 
                   
               
               
                   
                 ctacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaacca 
                   
               
               
                   
                 ggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcgcc 
                   
               
               
                   
                 agagacaagggctacagctactactacagcatggactactggggccagggcaccacc 
                   
               
               
                   
                 gtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgcag 
                   
               
               
                   
                 cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc 
                   
               
               
                   
                 gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc 
                   
               
               
                   
                 agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc 
                   
               
               
                   
                 agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc 
                   
               
               
                   
                 aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc 
                   
               
               
                   
                 ctgaatactgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga 
                   
               
               
                   
                 tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc 
                   
               
               
                   
                 cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa 
                   
               
               
                   
                 gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg 
                   
               
               
                   
                 caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg 
                   
               
               
                   
                 cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca 
                   
               
               
                   
                 agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt 
                   
               
               
                   
                 gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc 
                   
               
               
                   
                 ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc 
                   
               
               
                   
                 ctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca 
                 SEQ ID 
               
               
                   
                 ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg 
                 NO: 459 
               
               
                   
                 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg 
                   
               
               
                   
                 gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga 
                   
               
               
                   
                 ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga 
                   
               
               
                   
                 aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccgc 
                   
               
               
                   
                 tcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgt 
                   
               
               
                   
                 cgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtggac 
                   
               
               
                   
                 aatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaagg 
                   
               
               
                   
                 actccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaagc 
                   
               
               
                   
                 acaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga 
                   
               
               
                   
                 gcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaag 
                 SEQ ID 
               
               
                   
                 gtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgca 
                 NO: 460 
               
               
                   
                 gcgtgccaggacagggactgcagtggatgggctggatcagccacgagggcgacaag 
                   
               
               
                   
                 aaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgg gacagaagcacc 
                   
               
               
                   
                 aacaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactactg 
                   
               
               
                   
                 cgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacggcg 
                   
               
               
                   
                 ccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggccaggg 
                   
               
               
                   
                 cacagccgtgaccgtgtcatctgacaaaacccatacccaggtgcagctggtggaatctg 
                   
               
               
                   
                 gcggcggagtggtgcagcctggcagaagcctgagactgagctgtgccgccagcggc 
                   
               
               
                   
                 ttcaccttcaccaaggcctggatgcactgggtgcgccaggcccctggaaagcagctgg 
                   
               
               
                   
                 aatgggtggcccagatcaaggacaagagcaacagctacgccacctactacgccgaca 
                   
               
               
                   
                 gcgtgaagggccggttcaccatcagccgggacgacagcaagaacaccctgtacctgc 
                   
               
               
                   
                 agatgaacagcctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtacta 
                   
               
               
                   
                 tgccctgagccccttcgattactggggccagggaaccctcgtgaccgtgtctagtgataa 
                   
               
               
                   
                 gacccacaccgcttcgaccaagggcccatcggtgttccctctggccccttgcagcaga 
                   
               
               
                   
                 agcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccgagc 
                   
               
               
                   
                 ccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccagcc 
                   
               
               
                   
                 gtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagcagca 
                   
               
               
                   
                 gcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaagg 
                   
               
               
                   
                 tggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccctgaa 
                   
               
               
                   
                 tttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctgatgatc 
                   
               
               
                   
                 agccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcccgag 
                   
               
               
                   
                 gtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccca 
                   
               
               
                   
                 gagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcacca 
                   
               
               
                   
                 ggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgcccag 
                   
               
               
                   
                 ctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctcaagtgtg 
                   
               
               
                   
                 taccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagctgtgcc 
                   
               
               
                   
                 gtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggccagccc 
                   
               
               
                   
                 gagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcctggt 
                   
               
               
                   
                 gtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagctgctc 
                   
               
               
                   
                 cgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccctgg 
                   
               
               
                   
                 gcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcca 
                 SEQ ID 
               
               
                   
                 gcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctga 
                 NO: 461 
               
               
                   
                 gctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtccaa 
                   
               
               
                   
                 cagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcacc 
                   
               
               
                   
                 ctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccagggc 
                   
               
               
                   
                 acccagtaccccttcacctttggcagcggcaccaaggtggaaatcaaggacaaaaccc 
                   
               
               
                   
                 ataccgacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagag 
                   
               
               
                   
                 cgccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 
                   
               
               
                   
                 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggcca 
                   
               
               
                   
                 gcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggact 
                   
               
               
                   
                 tcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgca 
                   
               
               
                   
                 gggcagagagagcccctggacctttggccagggcaccaaggtggacatcaaggataa 
                   
               
               
                   
                 gacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagc 
                   
               
               
                   
                 agctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgag 
                   
               
               
                   
                 gccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaa 
                   
               
               
                   
                 gcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgaca 
                   
               
               
                   
                 ctgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccag 
                   
               
               
                   
                 ggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 52 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwaggg 
                 SEQ ID 
               
               
                   
                 tnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywgq 
                 NO: 462 
               
               
                   
                 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht 
                   
               
               
                   
                 fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc 
                   
               
               
                   
                 papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev 
                   
               
               
                   
                 hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg 
                   
               
               
                   
                 qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp 
                   
               
               
                   
                 pvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Divltqspaslayspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn 
                 SEQ ID 
               
               
                   
                 vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtvaa 
                 NO: 463 
               
               
                   
                 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk 
                   
               
               
                   
                 dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvqlvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaq 
                 SEQ ID 
               
               
                   
                 ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy 
                 NO: 464 
               
               
                   
                 alspfdywgqgtlvtvsssqvhltqsgpevrkpgtsvkvsckapgntlktydl 
                   
               
               
                   
                 hwvrsvpgqglqwmgwishegdkkviverfkakvtidwdrstntaylqls 
                   
               
               
                   
                 gltsgdtavyycakgskhrlrdyalydddgalnwavdvdylsnlefwgqgt 
                   
               
               
                   
                 avtvssrtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgalt 
                   
               
               
                   
                 sgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrvesk 
                   
               
               
                   
                 ygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpe 
                   
               
               
                   
                 vqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykck 
                   
               
               
                   
                 vsnkglpssiektiskakgqprepqvctlppsqeemtknqvslscavkgfyp 
                   
               
               
                   
                 sdiavewesngqpennykttppvldsdgsfflvskltvdksrwqegnvfscs 
                   
               
               
                   
                 vmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr 
                 SEQ ID 
               
               
                   
                 asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikgqp 
                 NO: 465 
               
               
                   
                 kaapdivmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliy 
                   
               
               
                   
                 kvsnrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikt 
                   
               
               
                   
                 kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq 
                   
               
               
                   
                 esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 52 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagcc 
                 SEQ ID 
               
               
                   
                 tgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcca 
                 NO: 466 
               
               
                   
                 gccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcaccaa 
                   
               
               
                   
                 ctacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaacca 
                   
               
               
                   
                 ggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcgcc 
                   
               
               
                   
                 agagacaagggctacagctactactacagcatggactactggggccagggcaccacc 
                   
               
               
                   
                 gtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgcag 
                   
               
               
                   
                 cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc 
                   
               
               
                   
                 gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc 
                   
               
               
                   
                 agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc 
                   
               
               
                   
                 agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc 
                   
               
               
                   
                 aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc 
                   
               
               
                   
                 ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga 
                   
               
               
                   
                 tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc 
                   
               
               
                   
                 cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa 
                   
               
               
                   
                 gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg 
                   
               
               
                   
                 caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg 
                   
               
               
                   
                 cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca 
                   
               
               
                   
                 agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt 
                   
               
               
                   
                 gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc 
                   
               
               
                   
                 ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc 
                   
               
               
                   
                 ctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca 
                 SEQ ID 
               
               
                   
                 ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg 
                 NO: 467 
               
               
                   
                 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg 
                   
               
               
                   
                 gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga 
                   
               
               
                   
                 ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga 
                   
               
               
                   
                 aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccgc 
                   
               
               
                   
                 tcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgt 
                   
               
               
                   
                 cgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtggac 
                   
               
               
                   
                 aatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaagg 
                   
               
               
                   
                 actccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaagc 
                   
               
               
                   
                 acaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga 
                   
               
               
                   
                 gcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgaga 
                 SEQ ID 
               
               
                   
                 ctgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgcc 
                 NO: 468 
               
               
                   
                 aggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacagc 
                   
               
               
                   
                 tacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacgac 
                   
               
               
                   
                 agcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccgtg 
                   
               
               
                   
                 tactactgtcggggcgtgtactatgccctgagccccttcgattactggggccagggaac 
                   
               
               
                   
                 cctcgtgaccgtgtctagtagccaggtgcacctgacacagagcggacccgaagtgcg 
                   
               
               
                   
                 gaagcctggcacctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacc 
                   
               
               
                   
                 tacgacctgcactgggtgcgcagcgtgccaggacagggactgcagtggatgggctgg 
                   
               
               
                   
                 atcagccacgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgacc 
                   
               
               
                   
                 atcgactgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctg 
                   
               
               
                   
                 gcgataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacg 
                   
               
               
                   
                 ccctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaa 
                   
               
               
                   
                 cctggaattctggggccagggcacagccgtgaccgtgtcatctcggaccgccagcaca 
                   
               
               
                   
                 aagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacag 
                   
               
               
                   
                 ccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaac 
                   
               
               
                   
                 tctggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcc 
                   
               
               
                   
                 tgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagaccta 
                   
               
               
                   
                 cacctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatc 
                   
               
               
                   
                 taagtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgt 
                   
               
               
                   
                 gacctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtg 
                   
               
               
                   
                 acctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgt 
                   
               
               
                   
                 ggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaaca 
                   
               
               
                   
                 gcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaa 
                   
               
               
                   
                 agagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc 
                   
               
               
                   
                 agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagccag 
                   
               
               
                   
                 gaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccca 
                   
               
               
                   
                 gcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagacc 
                   
               
               
                   
                 accccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgga 
                   
               
               
                   
                 caagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccct 
                   
               
               
                   
                 gcacaaccactacacccagaagtccctgtctctgtccctgggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccactccctgatccacggcgaccggaacaactacctg 
                 NO: 469 
               
               
                   
                 gcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggccagca 
                   
               
               
                   
                 gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggacttca 
                   
               
               
                   
                 ccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgcagg 
                   
               
               
                   
                 gcagagagagcccctggacctttggccagggcaccaaggtggacatcaagggccag 
                   
               
               
                   
                 cccaaggccgcccccgacatcgtgatgacccagacccccctgagcctgagcgtgaca 
                   
               
               
                   
                 cctggacagcctgccagcatcagctgcaagagcagccagagcctggtgcacaacaac 
                   
               
               
                   
                 gccaacacctacctgagctggtatctgcagaagcccggccagagcccccagtccctga 
                   
               
               
                   
                 tctacaaggtgtccaacagattcagcggcgtgcccgacagattctccggcagcggctct 
                   
               
               
                   
                 ggcaccgacttcaccctgaagatcagccgggtggaagccgaggacgtgggcgtgtac 
                   
               
               
                   
                 tattgtggccagggcacccagtaccccttcacctttggcagcggcaccaaggtggaaat 
                   
               
               
                   
                 caagaccaagggccccagccgtacggtggccgctcccagcgtgttcatcttcccacct 
                   
               
               
                   
                 agcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttcta 
                   
               
               
                   
                 cccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca 
                   
               
               
                   
                 gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagc 
                   
               
               
                   
                 accctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtg 
                   
               
               
                   
                 acccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 53 Amino Acid Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwaggg 
                 SEQ ID 
               
               
                   
                 tnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywgq 
                 NO: 470 
               
               
                   
                 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht 
                   
               
               
                   
                 fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc 
                   
               
               
                   
                 papeflggpsvflfppkpkdtlmisrtpevtcccvdvsqedpevqfnwyvdgvev 
                   
               
               
                   
                 hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg 
                   
               
               
                   
                 qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp 
                   
               
               
                   
                 pvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain A 
                 Divltqspaslayspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn 
                 SEQ ID 
               
               
                   
                 vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtvaa 
                 NO: 471 
               
               
                   
                 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk 
                   
               
               
                   
                 dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
               
                 Heavy chain B 
                 Qvqlvesgggvvqpgrslrlscaasgftftkawmhwyrqapgkqlewvaq 
                 SEQ ID 
               
               
                   
                 ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy 
                 NO: 472 
               
               
                   
                 alspfdywgqgtlvtvssdkthtqvhltqsgpevrkpgtsvkvsckapgntlk 
                   
               
               
                   
                 tydlhwyrsvpgqglqwmgwishegdkkviverfkakvtidwdrstntay 
                   
               
               
                   
                 lqlsgltsgdtavyycakgskhrlrdyalydddgalnwavdvdylsnlefwg 
                   
               
               
                   
                 qgtavtvssdkthtastkgpsvfplapcsrstsestaalgclykdyfpepvtvs 
                   
               
               
                   
                 wnsgaltsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkv 
                   
               
               
                   
                 dkrveskygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvd 
                   
               
               
                   
                 vsqedpevqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwln 
                   
               
               
                   
                 gkeykckvsnkglpssiektiskakgqprepqvctlppsqeemtknqvslsc 
                   
               
               
                   
                 avkgfypsdiavewesngqpennykttppyldsdgsfflvskltvdksrwq 
                   
               
               
                   
                 egnvfscsvmhealhnhytqkslslslgk 
                   
               
               
                   
               
               
                 Light chain B 
                 Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr 
                 SEQ ID 
               
               
                   
                 asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkth 
                 NO: 473 
               
               
                   
                 tdivmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs 
                   
               
               
                   
                 nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkth 
                   
               
               
                   
                 trtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt 
                   
               
               
                   
                 eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec 
                   
               
               
                   
               
            
           
           
               
            
               
                 Binding Protein 53 Nucleotide Sequences 
               
            
           
           
               
               
               
            
               
                 Heavy chain A 
                 caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagcc 
                 SEQ ID 
               
               
                   
                 tgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcca 
                 NO: 474 
               
               
                   
                 gccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcaccaa 
                   
               
               
                   
                 ctacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaacca 
                   
               
               
                   
                 ggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcgcc 
                   
               
               
                   
                 agagacaagggctacagctactactacagcatggactactggggccagggcaccacc 
                   
               
               
                   
                 gtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgcag 
                   
               
               
                   
                 cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc 
                   
               
               
                   
                 gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc 
                   
               
               
                   
                 agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc 
                   
               
               
                   
                 agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc 
                   
               
               
                   
                 aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc 
                   
               
               
                   
                 ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga 
                   
               
               
                   
                 tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc 
                   
               
               
                   
                 cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa 
                   
               
               
                   
                 gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg 
                   
               
               
                   
                 caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg 
                   
               
               
                   
                 cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca 
                   
               
               
                   
                 agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt 
                   
               
               
                   
                 gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca 
                   
               
               
                   
                 gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc 
                   
               
               
                   
                 ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct 
                   
               
               
                   
                 gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc 
                   
               
               
                   
                 ctgggcaag 
                   
               
               
                   
               
               
                 Light chain A 
                 gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca 
                 SEQ ID 
               
               
                   
                 ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg 
                 NO: 475 
               
               
                   
                 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg 
                   
               
               
                   
                 gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga 
                   
               
               
                   
                 ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga 
                   
               
               
                   
                 aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccgc 
                   
               
               
                   
                 tcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgt 
                   
               
               
                   
                 cgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtggac 
                   
               
               
                   
                 aatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaagg 
                   
               
               
                   
                 actccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaagc 
                   
               
               
                   
                 acaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga 
                   
               
               
                   
                 gcttcaaccggggcgagtgt 
                   
               
               
                   
               
               
                 Heavy chain B 
                 caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgaga 
                 SEQ ID 
               
               
                   
                 ctgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgcc 
                 NO: 476 
               
               
                   
                 aggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacagc 
                   
               
               
                   
                 tacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacgac 
                   
               
               
                   
                 agcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccgtg 
                   
               
               
                   
                 tactactgtcggggcgtgtactatgccctgagccccttcgattactggggccagggaac 
                   
               
               
                   
                 cctcgtgaccgtgtctagtgacaaaacccatacccaggtgcacctgacacagagcgga 
                   
               
               
                   
                 cccgaagtgcggaagcctggcacctctgtgaaggtgtcctgcaaggcccctggcaaca 
                   
               
               
                   
                 ccctgaaaacctacgacctgcactgggtgcgcagcgtgccaggacagggactgcagt 
                   
               
               
                   
                 ggatgggctggatcagccacgagggcgacaagaaagtgatcgtggaacggttcaagg 
                   
               
               
                   
                 ccaaagtgaccatcgactgggacagaagcaccaacaccgcctacctgcagctgagcg 
                   
               
               
                   
                 gcctgacctctggcgataccgccgtgtactactgcgccaagggcagcaagcaccggct 
                   
               
               
                   
                 gagagactacgccctgtacgacgatgacggcgccctgaactgggccgtggatgtgga 
                   
               
               
                   
                 ctacctgagcaacctggaattctggggccagggcacagccgtgaccgtgtcatctgata 
                   
               
               
                   
                 agacccacaccgccagcacaaagggcccatcggtgttccctctggccccttgcagcag 
                   
               
               
                   
                 aagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccgag 
                   
               
               
                   
                 cccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccagc 
                   
               
               
                   
                 cgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagcagc 
                   
               
               
                   
                 agcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaag 
                   
               
               
                   
                 gtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccctga 
                   
               
               
                   
                 atttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctgatgat 
                   
               
               
                   
                 cagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcccga 
                   
               
               
                   
                 ggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcc 
                   
               
               
                   
                 cagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcac 
                   
               
               
                   
                 caggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgccc 
                   
               
               
                   
                 agctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctcaagt 
                   
               
               
                   
                 gtgtaccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagctgt 
                   
               
               
                   
                 gccgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggccag 
                   
               
               
                   
                 cccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct 
                   
               
               
                   
                 ggtgtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagctg 
                   
               
               
                   
                 ctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccct 
                   
               
               
                   
                 gggcaag 
                   
               
               
                   
               
               
                 Light chain B 
                 gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcgcc 
                 SEQ ID 
               
               
                   
                 agcatcagctgcaagagcagccactccctgatccacggcgaccggaacaactacctg 
                 NO: 477 
               
               
                   
                 gcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggccagca 
                   
               
               
                   
                 gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggacttca 
                   
               
               
                   
                 ccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgcagg 
                   
               
               
                   
                 gcagagagagcccctggacctttggccagggcaccaaggtggacatcaaggacaaa 
                   
               
               
                   
                 acccataccgacatcgtgatgacccagacccccctgagcctgagcgtgacacctggac 
                   
               
               
                   
                 agcctgccagcatcagctgcaagagcagccagagcctggtgcacaacaacgccaaca 
                   
               
               
                   
                 cctacctgagctggtatctgcagaagcccggccagagcccccagtccctgatctacaa 
                   
               
               
                   
                 ggtgtccaacagattcagcggcgtgcccgacagattctccggcagcggctctggcacc 
                   
               
               
                   
                 gacttcaccctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtg 
                   
               
               
                   
                 gccagggcacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagg 
                   
               
               
                   
                 ataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcgac 
                   
               
               
                   
                 gagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccg 
                   
               
               
                   
                 cgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccag 
                   
               
               
                   
                 gaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccct 
                   
               
               
                   
                 gacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgaccca 
                   
               
               
                   
                 ccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE A 
               
               
                   
               
             
            
               
                 CDR sequences of binding proteins 
               
            
           
           
               
               
               
               
            
               
                 Ab 
                 CDRH1 
                 CDRH2 
                 CDRH3 
               
               
                   
               
               
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
               
               
                 Ab 
                 CDRL1 
                 CDRL2 
                 CDRL3 
               
               
                   
               
               
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
               
               
                 Ab 
                 CDRH1 
                 CDRH2 
                 CDRH3 
               
               
                   
               
               
                 Anti-CD28 
                 GYTFTSYY  
                 IYPGNVNT  
                 trshygldwnfdv  
               
               
                   
                 (SEQ ID NO: 479) 
                 (SEQ ID NO: 480) 
                 (SEQ ID NO: 481) 
               
               
                 Anti-CD28 
                 GFSLSDYG  
                 IWAGGGT  
                 ardkgysyyysmd  
               
               
                   
                 (SEQ ID NO: 482) 
                 (SEQ ID NO: 483) 
                 (SEQ ID NO: 484) 
               
               
                 Anti-CD3 
                 GFTFTKAW  
                 IKDKSNS  
                 rgvyyalspfdy  
               
               
                   
                 (SEQ ID NO: 485) 
                 (SEQ ID NO: 486) 
                 (SEQ ID NO:487) 
               
               
                   
               
               
                 Ab 
                 CDRL1 
                 CDRL2 
                 CDRL3 
               
               
                   
               
               
                 Anti-CD28 
                 QNIYVW  
                 KAS  
                 qqgqtypyt  
               
               
                   
                 (SEQ ID NO: 488) 
                 (SEQ ID NO: 489) 
                 (SEQ ID NO: 490) 
               
               
                 Anti-CD28 
                 ESVEYYVTSL  
                 AAS  
                 qqsrkvpyt  
               
               
                   
                 (SEQ ID NO: 491) 
                 (SEQ ID NO: 492) 
                 (SEQ ID NO: 493) 
               
               
                 Anti-CD3 
                 QSLVHNNANTY  
                 KVS  
                 gqgtqyp 
               
               
                   
                 (SEQ ID NO: 494) 
                 (SEQ ID NO: 495) 
                 (SEQ ID NO: 496) 
               
               
                   
               
               
                     indicates data missing or illegible when filed 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE B 
               
             
            
               
                   
               
               
                 CDR sequences of parental antibodies 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Ab 
                 CDR_Hl 
                 CDR_H2 
                 CDR_H3 
                 CDR_L1 
                 CDR_L2 
                 CDR_L3 
               
               
                   
               
               
                 CD4BS 
                 DCTLN 
                 LKPRGGAVNYARP 
                 GKNCDYNWDFEH 
                 RTSQYGSLA 
                 SGSTRAA 
                 QQYEF 
               
               
                 “a” 
                 (SEQ ID  
                 LQ 
                 (SEQ ID NO: 250) 
                 (SEQ ID NO: 266) 
                 (SEQ ID NO: 267) 
                 (SEQ ID  
               
               
                   
                 NO: 248) 
                 (SEQ ID NO: 497) 
                   
                   
                   
                 NO: 268) 
               
               
                 CD4BS 
                 GYTFTAHI 
                 IKPQYGAV 
                 DRSYGDSSWALDA 
                 QGVGSD 
                 HTS 
                 QVLQF (SEQ  
               
               
                 “b” 
                 (SEQ ID  
                 (SEQ ID NO: 252) 
                 (SEQ ID NO: 253) 
                 (SEQ ID NO: 269) 
                 (SEQ ID NO: 270) 
                 ID NO: 271) 
               
               
                   
                 NO: 251) 
                   
                   
                   
                   
                   
               
               
                 MPER 
                 GFDFDNAW 
                 ITGPGEGWSV 
                 TGKYYDFWSGYPPGEEYFQ 
                 SLRSHY 
                 GKN 
                 SSRDKSGSRLSV 
               
               
                   
                 (SEQ ID  
                 (SEQ ID NO: 255) 
                 D 
                 (SEQ ID NO: 500) 
                 (SEQ ID NO: 501) 
                 (SEQ ID  
               
               
                   
                 NO: 254) 
                   
                 (SEQ ID NO: 256) 
                   
                   
                 NO: 274) 
               
               
                 MPER_ 
                 GFDFDNAW 
                 ITGPGEGWSV 
                 TGKYYDFWWGYPPGEEYF 
                 SLRSHY 
                 GKN 
                 SSRDKSGSRLSV 
               
               
                 100W 
                 (SEQ ID  
                 (SEQ ID NO: 255) 
                 QD 
                 (SEQ ID NO: 500) 
                 (SEQ ID NO: 501) 
                 (SEQ ID  
               
               
                   
                 NO: 254) 
                   
                 (SEQ ID NO: 498) 
                   
                   
                 NO: 274) 
               
               
                 V1/V2 
                 GNTLKTYD 
                 ISHEGDKK 
                 CAKGSKHRLRDYALYDDD 
                 HSLIHGDRNNY 
                 LAS 
                 CMQGRESPWTF 
               
               
                 directed 
                 (SEQ ID  
                 (SEQ ID NO: 258) 
                 GALNWAVDVDYLSNLEFW 
                 (SEQ ID NO: 275) 
                 (SEQ ID NO: 276) 
                 (SEQ ID  
               
               
                 “a” 
                 NO: 257) 
                   
                 (SEQ ID NO: 259) 
                   
                   
                 NO: 277) 
               
               
                 V1/V2 
                 QFRFDGYG 
                 ISHDGIKK 
                 CAKDLREDECEEWWSDYY 
                 TSNIGNNF 
                 ETD 
                 ATWAASLSSARV 
               
               
                 directed 
                 (SEQ ID  
                 (SEQ ID NO: 264) 
                 DFGKQLPCAKSRGGLVGIA 
                 (SEQ ID NO: 281) 
                 (SEQ ID NO: 282) 
                 (SEQ ID  
               
               
                 “b” 
                 NO: 263) 
                   
                 DNW 
                   
                   
                 NO: 283) 
               
               
                   
                   
                   
                 (SEQ ID NO: 265) 
                   
                   
                   
               
               
                 V3 
                 GASISDSY 
                 VHKSGDT 
                 ARTLHGRRIYGIVAFNEWF 
                 SLGSRA 
                 NNQ 
                 HIWDSRVPTKWV 
               
               
                 directed 
                 (SEQ ID  
                 (SEQ ID NO: 261) 
                 TYFYMDV 
                 (SEQ ID NO: 278) 
                 (SEQ ID NO: 279) 
                 (SEQ ID  
               
               
                   
                 NO: 499) 
                   
                 (SEQ ID NO: 262) 
                   
                   
                 NO: 280) 
               
               
                 CD28 
                 GYTFTSYY 
                 IYPGNVNT 
                 TRSHYGLDWNFDV 
                 QNIYVW 
                 KAS 
                 QQGQTYPYT 
               
               
                   
                 (SEQ ID  
                 (SEQ ID NO: 480) 
                 (SEQ ID NO: 481) 
                 (SEQ ID NO: 488) 
                 (SEQ ID NO: 489) 
                 (SEQ ID  
               
               
                   
                 NO: 479) 
                   
                   
                   
                   
                 NO: 490) 
               
               
                 CD28_ 
                 GFSLSDYG 
                 IWAGGGT 
                 ARDKGYSYYYSMD 
                 ESVEYYVTSL 
                 AAS 
                 QQSRKVPYT 
               
               
                 2 
                 (SEQ ID  
                 (SEQ ID NO:483) 
                 (SEQ ID NO: 484) 
                 (SEQ ID NO: 491) 
                 (SEQ ID NO: 492) 
                 (SEQ ID  
               
               
                   
                 NO: 482) 
                   
                   
                   
                   
                 NO: 493) 
               
               
                 CD3 
                 GFTFTKAW 
                 IKDKSNS 
                 RGVYYALSPFDY 
                 QSLVHNNANTY 
                 KVS 
                 GQGTQYP (SEQ  
               
               
                   
                 (SEQ ID  
                 (SEQ ID NO: 486) 
                 (SEQ ID NO: 487) 
                 (SEQ ID NO: 494) 
                 (SEQ ID NO: 495) 
                 ID NO: 496) 
               
               
                   
                 NO: 485) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE C 
               
             
            
               
                   
               
               
                 Variable domain sequences of parental antibodies 
               
            
           
           
               
               
               
            
               
                 Ab Name 
                 V H   
                 V L   
               
               
                   
               
               
                 CD4BS “a” 
                 QVQLVQSGGQMKKPGESMRISCRASGYEFI DCTLN WIRLAP 
                 EIVLTQSPGTLSLSPGETAIISC RTSQYGSLA WYQQ 
               
               
                   
                 GKRPEWMGW LKPRGGAVNYARPLQ GRVTMTRDVYSDTAF 
                 RPGQAPRLVIY SGSTRAA GIPDRFSGSRWGPDYNL 
               
               
                   
                 LELRSLTVDDTAVYFCTR GKNCDYNWDFEH WGRGTPVIVS 
                 TISNLESGDFGVYYC QQYEF FGQGTKVQVDIK 
               
               
                   
                 S 
                 (SEQ ID NO: 512) 
               
               
                   
                 (SEQ ID NO: 502) 
                   
               
               
                 CD4BS “b” 
                 RAHLVQSGTAMKKPGASVRVSCQTS GYTFTAHI LFWFRQAP 
                 YIHVTQSPSSLSVSIGDRVTINCQTS QGVGSD LHW 
               
               
                   
                 GRGLEWVGW IKPQYGAV NFGGGFRDRVTLTRDVYREIAY 
                 YQHKPGRAPKLLIH HTS SVEDGVPSRFSGSGFHTS 
               
               
                   
                 MDIRGLKPDDTAVYYCAR DRSYGDSSWALDA WGQGTTVV 
                 FNLTISDLQADDIATYYC QVLQF FGRGSRLHIK 
               
               
                   
                 VSA 
                 (SEQ ID NO: 513) 
               
               
                   
                 (SEQ ID NO: 503) 
                   
               
               
                 CD4BS “b” 
                 RAHLVQSGTAMKKPGASVRVSCQTS GYTFTAHI LFWFRQAP 
                 YIHVTQSPSSLSVSIGDRVTINCQTS QGVGSD LHW 
               
               
                 (Aglycan) 
                 GRGLEWVGW IKPQYGAV NFGGGFRDRVTLTRDVYREIAY 
                 YQHKPGRAPKLLIH HTS SVEDGVPSRFSGSGFHTS 
               
               
                   
                 MDIRGLKPDDTAVYYCAR DRSYGDSSWALDA WGQGTTVV 
                 FQLTISDLQADDIATYYC QVLQF FGRGSRLHIK 
               
               
                   
                 VSA 
                 (SEQ ID NO: 514) 
               
               
                   
                 (SEQ ID NO: 503) 
                   
               
               
                 CD4BS “b” 
                 RAHLVQSGTAMKKPGASVRVSCQTS GYTFTAHI LFWFRQAP 
                 YIHVTQSPSSLSVSIGDRVTINCQTS QGVGSD LHW 
               
               
                 (Δisomerization 
                 GRGLEWVGW IKPQYGAV NFGGGFRDRVTLTRDVYREIAY 
                 YQHKPGRAPKLLIH HTS SVEEGVPSRFSGSGFHTS 
               
               
                 D55E) 
                 MDIRGLKPDDTAVYYCAR DRSYGDSSWALDA WGQGTTVV 
                 FNLTISDLQADDIATYYC QVLQF FGRGSRLHIK 
               
               
                   
                 VSA 
                 (SEQ ID NO: 515) 
               
               
                   
                 (SEQ ID NO: 503) 
                   
               
               
                 CD4BS “b” 
                 RAHLVQSGTAMKKPGASVRVSCQTS GYTFTAHI LFWFRQAP 
                 YIHVTQSPSSLSVSIGDRVTINCQTS QGVGSD LHW 
               
               
                 (Δisomerization 
                 GRGLEWVGW IKPQYGAV NFGGGFRDRVTLTRDVYREIAY 
                 YQHKPGRAPKLLIH HTS SVEDAVPSRFSGSGFHTS 
               
               
                 G56A)  
                 MDIRGLKPDDTAVYYCAR DRSYGDSSWALDA WGQGTTVV 
                 FNLTISDLQADDIATYYC QVLQF FGRGSRLHIK 
               
               
                   
                 VSA 
                 (SEQ ID NO: 516) 
               
               
                   
                 (SEQ ID NO: 503) 
                   
               
               
                 CD4BS “b” 
                 RAHLVQSGTAMKKPGASVRVSCQTS GYTFTAHI LFWFRQAP 
                 YIHVTQSPSSLSVSIGDRVTINCQTS QGVGSD LHW 
               
               
                 (Δglycan/ 
                 GRGLEWVGW IKPQYGAV NFGGGFRDRVTLTRDVYREIAY 
                 YQHKPGRAPKLLIH HTS SVE E GVPSRFSGSGFHTS 
               
               
                 Δisomerization 
                 MDIRGLKPDDTAVYYCAR DRSYGDSSWALDA WGQGTTVV 
                 F Q LTISDLQADDIATYYC QVLQF FGRGSRLHIK 
               
               
                 D55E) 
                 VSA 
                 (SEQ ID NO: 517) 
               
               
                   
                 (SEQ ID NO: 503) 
                   
               
               
                 MPER 
                 EVRLVESGGGLVKPGGSLRLSCSAS GFDFDNAW MTWVRQP 
                 ASELTQDPAVSVALKQTVTITCRGD SLRSHY ASW 
               
               
                   
                 PGKGLEWVGR ITGPGEGWSV DYAESVKGRFTISRDNTKNTL 
                 YQKKPGQAPVLLFY GKN NRPSGIPDRFSGSASGN 
               
               
                   
                 YLEMNNVRTEDTGYYFCAR TGKYYDFWSGYPPGEEYFQD   
                 RASLTITGAQAEDEADYYC SSRDKSGSRLSV FGG 
               
               
                   
                 WGQGTLVIVSS 
                 GTKLTVL 
               
               
                   
                 (SEQ ID NO: 504) 
                 (SEQ ID NO: 518) 
               
               
                 MPER_100W 
                 EVRLVESGGGLVKPGGSLRLSCSAS GFDFDNAW MTWVRQP 
                 ASELTQDPAVSVALKQTVTITCRGD SLRSHY ASW 
               
               
                   
                 PGKGLEWVGR ITGPGEGWSV DYAESVKGRFTISRDNTKNTL 
                 YQKKPGQAPVLLFY GKN NRPSGIPDRFSGSASGN 
               
               
                   
                 YLEMNNVRTEDTGYYFCAR TGKYYDFW W GYPPGEEYFQD   
                 RASLTITGAQAEDEADYYC SSRDKSGSRLSV FGG 
               
               
                   
                 WGQGTLVIVSS 
                 GTKLTVL 
               
               
                   
                 (SEQ ID NO: 505) 
                 (SEQ ID NO: 518) 
               
               
                 V1/V2 
                 QVHLTQSGPEVRKPGTSVKVSCKAP GNTLKTYD LHWVRSV 
                 DFVLTQSPHSLSVTPGESASISCKSS HSLIHGDRNN   
               
               
                 directed “a” 
                 PGQGLQWMGW ISHEGDKK VIVERFKAKVTIDWDRSTNTAY 
                   Y LAWYVQKPGRSPQLLIY LAS SRASGVPDRFSGS 
               
               
                   
                 LQLSGLTSGDTAVYY CAKGSKHRLRDYALYDDDGALNWA   
                 GSDKDFTLKISRVETEDVGTYY CMQGRESPWTF G 
               
               
                   
                   VDVDYLSNLEFW GQGTAVTVSS 
                 QGTKVDIK 
               
               
                   
                 (SEQ ID NO: 506) 
                 (SEQ ID NO: 519) 
               
               
                 V1/V2 
                 QVQLVESGGGVVQPGTSLRLSCAAS QFRFDGYG MHWVRQ 
                 QSVLTQPPSVSAAPGQKVTISCSGN TSNIGNNF VS 
               
               
                 directed “b” 
                 APGKGLEWVAS ISHDGIKK YHAEKVWGRFTISRDNSKNTLY 
                 WYQQRPGRAPQLLIY ETD KRPSGIPDRFSASKSGT 
               
               
                   
                 LQMNSLRPEDTALYY CAKDLREDECEEWWSDYYDFGKQLP   
                 SGTLAITGLQTGDEADYYC ATWAASLSSARV FGT 
               
               
                   
                   CAKSRGGLVGIADNW GQGTMVTVSS 
                 GTKVIVL 
               
               
                   
                 (SEQ ID NO: 507) 
                 (SEQ ID NO: 520) 
               
               
                 V3 directed 
                 QMQLQESGPGLVKPSETLSLTCSVS GASISDSY WSWIRRSPG 
                 SDISVAPGETARISCGEK SLGSRA VQWYQHRAGQ 
               
               
                   
                 KGLEWIGY VHKSGDT NYSPSLKSRVNLSLDTSKNQVSLSLV 
                 APSLIIY NNQ DRPSGIPERFSGSPDSPFGTTATLTIT 
               
               
                   
                 AATAADSGKYYC ARTLHGRRIYGIVAFNEWFTYFYMDV W 
                 SVEAGDEADYYC HIWDSRVPTKWV FGGGTTLTV 
               
               
                   
                 GNGTQVTVSS 
                 L 
               
               
                   
                 (SEQ ID NO: 508) 
                 (SEQ ID NO: 521) 
               
               
                 CD28 
                 QVQLVQSGAEVVKPGASVKVSCKAS GYTFTSYY IHWVRQA 
                 DIQMTQSPSSLSASVGDRVTITCQAS QNIYVW LN 
               
               
                   
                 PGQGLEWIGS IYPGNVNT NYAQKFQGRATLTVDTSISTAYM 
                 WYQQKPGKAPKLLIY KAS NLHTGVPSRFSGSGSG 
               
               
                   
                 ELSRLRSDDTAVYYC TRSHYGLDWNFDV WGKGTTVTVSS 
                 TDFTLTISSLQPEDIATYYC QQGQTYPYT FGQGTK 
               
               
                   
                 (SEQ ID NO: 509) 
                 LEIK 
               
               
                   
                   
                 (SEQ ID NO: 522) 
               
               
                 CD28_2 
                 QVQLQESGPGLVKPSQTLSLTCTVS GFSLSDYG VHWVRQPP 
                 DIVLTQSPASLAVSPGQRATITCRAS ESVEYYVTS   
               
               
                   
                 GKGLEWLGV IWAGGGT NYNPSLKSRKTISKDTSKNQVSLKL 
                   L MQWYQQKPGQPPKLLIF AAS NVESGVPARFSGS 
               
               
                   
                 SSVTAADTAVYYC ARDKGYSYYYSMDY WGQGTTVTVSS 
                 GSGTDFTLTINPVEANDVANYYC QQSRKVPYT FG 
               
               
                   
                 (SEQ ID NO: 510) 
                 QGTKLEIK 
               
               
                   
                   
                 (SEQ ID NO: 523) 
               
               
                 CD3 
                 QVQLVESGGGVVQPGRSLRLSCAAS GFTFTKAW MHWVRQ 
                 DIVMTQTPLSLSVTPGQPASISCKSS QSLVHNNAN   
               
               
                   
                 APGKQLEWVAQ IKDKSNS YATYYADSVKGRFTISRDDSKNT 
                   TY LSWYLQKPGQSPQSLIY KVS NRFSGVPDRFSGS 
               
               
                   
                 LYLQMNSLRAEDTAVYYC RGVYYALSPFDY WGQGTLVTV 
                 GSGTDFTLKISRVEAEDVGVYYC GQGTQYP FTFG 
               
               
                   
                 SS 
                 SGTKVEIK 
               
               
                   
                 (SEQ ID NO: 511) 
                 (SEQ ID NO: 524) 
               
               
                   
               
               
                 CDR sequences are underlined. 
               
               
                 Variable domain modifications are shown in bold and italicized.