Patent Publication Number: US-6706869-B1

Title: Map kinase phosphatases and polynucleotides encoding them

Description:
This application is a continuation-in-part of the following applications: 
     (1) provisional application Ser. No. 60/075,118, filed Feb. 11, 1998, now abandoned; 
     (2) application Ser. No. 09/248,059, filed Feb. 10, 1999 (now abandoned); which is a continuation-in-part of provisional application Ser. No. 60/075,118, filed Feb. 11, 1998, now abandoned; 
     (3) provisional application Ser. No. 60/080,969, filed Apr. 7, 1998, now abandoned; 
     (4) application Ser. No. 09/287,150, filed Apr. 6, 1999 (now abandoned); which is a continuation-in-part of provisional application Ser. No. 60/080,969, filed Apr. 7, 1998, now abandoned; 
     (5) provisional application Ser. No. 60/085,472, filed May 14, 1998; 
     (6) provisional application Ser. No. 60/096,824, filed Aug. 17, 1998; 
     (7) provisional application Ser. No. 60/099,950, filed Sep. 11, 1998; 
     (8) provisional application Ser. No. 60/099,843, filed Sep. 11, 1998; 
     (9) provisional application Ser. No. 60/100,424, filed Sep. 15, 1998; 
     (10) provisional application Ser. No. 60/102,329, filed Sep. 29, 1998; 
     (11) provisional application Ser. No. 60/103,615, filed Oct. 9, 1998; 
     (12) provisional application Ser. No. 60/111,799, filed Dec. 11, 1998; 
     (13) provisional application Ser. No. 60/112,159, filed Dec. 14, 1998; 
     (14) provisional application Ser. No. 60/114,415, filed Dec. 31, 1998; 
     all of which are incorporated by reference herein. 
    
    
     FIELD OF THE INVENTION 
     The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. 
     BACKGROUND OF THE INVENTION 
     Technology aimed at the discovery of protein factors (including e.g., cytokines, such as lymphokines, interferons, CSFs and interleukins) has matured rapidly over the past decade. The now routine hybridization cloning and expression cloning techniques clone novel polynucleotides “directly” in the sense that they rely on information directly related to the discovered protein (i.e., partial DNA/amino acid sequence of the protein in the case of hybridization cloning; activity of the protein in the case of expression cloning). More recent “indirect” cloning techniques such as signal sequence cloning, which isolates DNA sequences based on the presence of a now well-recognized secretory leader sequence motif, as well as various PCR-based or low stringency hybridization cloning techniques, have advanced the state of the art by making available large numbers of DNA/amino acid sequences for proteins that are known to have biological activity by virtue of their secreted nature in the case of leader sequence cloning, or by virtue of the cell or tissue source in the case of PCR-based techniques. It is to these proteins and the polynucleotides encoding them that the present invention is directed. 
     SUMMARY OF THE INVENTION 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 from nucleotide 29 to nucleotide 253; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ya15 — 1 deposited under accession number ATCC 98650; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ya15 — 1 deposited under accession number ATCC 98650; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ya15 — 1 deposited under accession number ATCC 98650; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ya15 — 1 deposited under accession number ATCC 98650; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:2; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:2 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:2; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:1. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:1 from nucleotide 29 to nucleotide 253; the nucleotide sequence of the full-length protein coding sequence of clone ya15 — 1 deposited under accession number ATCC 98650; or the nucleotide sequence of a mature protein coding sequence of clone ya15 — 1 deposited under accession number ATCC 98650. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ya15 — 1 deposited under accession number ATCC 98650. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:2 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:2, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:2 having biological activity, the fragment comprising the amino acid sequence from amino acid 32 to amino acid 41 of SEQ ID NO:2. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:1. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:1, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:1; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ya15 — 1 deposited under accession number ATCC 98650; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:1, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:1; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ya15 — 1 deposited under accession number ATCC 98650; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:1, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:1 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:1, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:1. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:1 from nucleotide 29 to nucleotide 253, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:1 from nucleotide 29 to nucleotide 253, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:1 from nucleotide 29 to nucleotide 253. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:2; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:2, the fragment comprising eight contiguous amino acids of SEQ ID NO:2; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ya15 — 1 deposited under accession number ATCC 98650; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:2. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:2 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:2, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:2 having biological activity, the fragment comprising the amino acid sequence from amino acid 32 to amino acid 41 of SEQ ID NO:2. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:3; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:3 from nucleotide 151 to nucleotide 288; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:3 from nucleotide 196 to nucleotide 288; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ya24 — 1 deposited under accession number ATCC 98650; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ya24 — 1 deposited under accession number ATCC 98650; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ya24 — 1 deposited under accession number ATCC 98650; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ya24 — 1 deposited under accession number ATCC 98650; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:4; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:4 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:4; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:3. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:3 from nucleotide 151 to nucleotide 288; the nucleotide sequence of SEQ ID NO:3 from nucleotide 196 to nucleotide 288; the nucleotide sequence of the full-length protein coding sequence of clone ya24 — 1 deposited under accession number ATCC 98650; or the nucleotide sequence of a mature protein coding sequence of clone ya24 — 1 deposited under accession number ATCC 98650. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ya24 — 1 deposited under accession number ATCC 98650. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:4 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:4, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:4 having biological activity, the fragment comprising the amino acid sequence from amino acid 18 to amino acid 27 of SEQ ID NO:4. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:3. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:3, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:3; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ya24 — 1 deposited under accession number ATCC 98650; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:3, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:3; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ya24 — 1 deposited under accession number ATCC 98650; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:3, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:3 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:3, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:3. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:3 from nucleotide 151 to nucleotide 288, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:3 from nucleotide 151 to nucleotide 288, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:3 from nucleotide 151 to nucleotide 288. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:3 from nucleotide 196 to nucleotide 288, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:3 from nucleotide 196 to nucleotide 288, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:3 from nucleotide 196 to nucleotide 288. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:4; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:4, the fragment comprising eight contiguous amino acids of SEQ ID NO:4; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ya24 — 1 deposited under accession number ATCC 98650; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:4. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:4 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:4, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:4 having biological activity, the fragment comprising the amino acid sequence from amino acid 18 to amino acid 27 of SEQ ID NO:4. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:5; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:5 from nucleotide 615 to nucleotide 908; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:5 from nucleotide 774 to nucleotide 908; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb42 — 1 deposited under accession number ATCC 98650; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb42 — 1 deposited under accession number ATCC 98650; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb42 — 1 deposited under accession number ATCC 98650; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb42 — 1 deposited under accession number ATCC 98650; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:6; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:6 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:6; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:5. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:5 from nucleotide 615 to nucleotide 908; the nucleotide sequence of SEQ ID NO:5 from nucleotide 774 to nucleotide 908; the nucleotide sequence of the full-length protein coding sequence of clone yb42 — 1 deposited under accession number ATCC 98650; or the nucleotide sequence of a mature protein coding sequence of clone yb42 — 1 deposited under accession number ATCC 98650. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb42 — 1 deposited under accession number ATCC 98650. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:6 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:6, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:6 having biological activity, the fragment comprising the amino acid sequence from amino acid 44 to amino acid 53 of SEQ ID NO:6. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:5. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:5, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:5; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb42 — 1 deposited under accession number ATCC 98650; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:5, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:5; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb42 — 1 deposited under accession number ATCC 98650; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:5, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:5 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:5, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:5. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:5 from nucleotide 615 to nucleotide 908, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:5 from nucleotide 615 to nucleotide 908, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:5 from nucleotide 615 to nucleotide 908. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:5 from nucleotide 774 to nucleotide 908, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:5 from nucleotide 774 to nucleotide 908, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:5 from nucleotide 774 to nucleotide 908. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:6; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:6, the fragment comprising eight contiguous amino acids of SEQ ID NO:6; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb42 — 1 deposited under accession number ATCC 98650; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:6. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:6 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:6, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:6 having biological activity, the fragment comprising the amino acid sequence from amino acid 44 to amino acid 53 of SEQ ID NO:6. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:7; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:7 from nucleotide 1203 to nucleotide 2327; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yc9 — 1 deposited under accession number ATCC 98650; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yc9 — 1 deposited under accession number ATCC 98650; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yc9 — 1 deposited under accession number ATCC 98650; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yc9 — 1 deposited under accession number ATCC 98650; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:8; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:8 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:8; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:7. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:7 from nucleotide 1203 to nucleotide 2327; the nucleotide sequence of the full-length protein coding sequence of clone yc9 — 1 deposited under accession number ATCC 98650; or the nucleotide sequence of a mature protein coding sequence of clone yc9 — 1 deposited under accession number ATCC 98650. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yc9 — 1 deposited under accession number ATCC 98650. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:8 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:8, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:8 having biological activity, the fragment comprising the amino acid sequence from amino acid 182 to amino acid 191 of SEQ ID NO:8. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:7. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:7, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:7; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yc9 — 1 deposited under accession number ATCC 98650; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:7, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:7; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yc9 — 1 deposited under accession number ATCC 98650; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:7, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:7 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:7, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:7. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:7 from nucleotide 1203 to nucleotide 2327, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:7 from nucleotide 1203 to nucleotide 2327, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:7 from nucleotide 1203 to nucleotide 2327. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:8; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:8, the fragment comprising eight contiguous amino acids of SEQ ID NO:8; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yc9 — 1 deposited under accession number ATCC 98650; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:8. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:8 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:8, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:8 having biological activity, the fragment comprising the amino acid sequence from amino acid 182 to amino acid 191 of SEQ ID NO:8. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:9; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:9 from nucleotide 230 to nucleotide 823; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:9 from nucleotide 584 to nucleotide 823; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yc19 — 1 deposited under accession number ATCC 98650; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yc19 — 1 deposited under accession number ATCC 98650; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yc19 — 1 deposited under accession number ATCC 98650; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yc19 — 1 deposited under accession number ATCC 98650; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:10; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:10 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:10; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:9. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:9 from nucleotide 230 to nucleotide 823; the nucleotide sequence of SEQ ID NO:9 from nucleotide 584 to nucleotide 823; the nucleotide sequence of the full-length protein coding sequence of clone yc19 — 1 deposited under accession number ATCC 98650; or the nucleotide sequence of a mature protein coding sequence of clone yc19 — 1 deposited under accession number ATCC 98650. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yc19 — 1 deposited under accession number ATCC 98650. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:10 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:10, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:10 having biological activity, the fragment comprising the amino acid sequence from amino acid 94 to amino acid 103 of SEQ ID NO:10. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:9. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:9, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:9; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yc19 — 1 deposited under accession number ATCC 98650; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:9, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:9; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yc19 — 1 deposited under accession number ATCC 98650; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:9, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:9 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:9, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:9. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:9 from nucleotide 230 to nucleotide 823, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:9 from nucleotide 230 to nucleotide 823, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:9 from nucleotide 230 to nucleotide 823. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:9 from nucleotide 584 to nucleotide 823, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:9 from nucleotide 584 to nucleotide 823, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:9 from nucleotide 584 to nucleotide 823. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:10; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:10, the fragment comprising eight contiguous amino acids of SEQ ID NO:10; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yc19 — 1 deposited under accession number ATCC 98650; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:10. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:10 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:10, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:10 having biological activity, the fragment comprising the amino acid sequence from amino acid 94 to amino acid 103 of SEQ ID NO:10. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:11; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:11 from nucleotide 292 to nucleotide 534; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yc20 — 1 deposited under accession number ATCC 98650; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yc20 — 1 deposited under accession number ATCC 98650; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yc20 — 1 deposited under accession number ATCC 98650; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yc20 — 1 deposited under accession number ATCC 98650; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:12; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:12 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:12; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:11. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:11 from nucleotide 292 to nucleotide 534; the nucleotide sequence of the full-length protein coding sequence of clone yc20 — 1 deposited under accession number ATCC 98650; or the nucleotide sequence of a mature protein coding sequence of clone yc20 — 1 deposited under accession number ATCC 98650. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yc20 — 1 deposited under accession number ATCC 98650. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:12 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:12, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:12 having biological activity, the fragment comprising the amino acid sequence from amino acid 35 to amino acid 44 of SEQ ID NO:12. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:11. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:11, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:11; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yc20 — 1 deposited under accession number ATCC 98650; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:11, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:11; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yc20 — 1 deposited under accession number ATCC 98650; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:11, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:11 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:11, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:11. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:11 from nucleotide 292 to nucleotide 534, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:11 from nucleotide 292 to nucleotide 534, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:11 from nucleotide 292 to nucleotide 534. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:12; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:12, the fragment comprising eight contiguous amino acids of SEQ ID NO:12; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yc20 — 1 deposited under accession number ATCC 98650; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:12. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:12 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:12, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:12 having biological activity, the fragment comprising the amino acid sequence from amino acid 35 to amino acid 44 of SEQ ID NO:12. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:13; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:13 from nucleotide 45 to nucleotide 590; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:13 from nucleotide 126 to nucleotide 590; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ya9 — 1 deposited under accession number ATCC 98724; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ya9 — 1 deposited under accession number ATCC 98724; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ya9 — 1 deposited under accession number ATCC 98724; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ya9 — 1 deposited under accession number ATCC 98724; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:14; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:14 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:14; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:13. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:13 from nucleotide 45 to nucleotide 590; the nucleotide sequence of SEQ ID NO:13 from nucleotide 126 to nucleotide 590; the nucleotide sequence of the full-length protein coding sequence of clone ya9 — 1 deposited under accession number ATCC 98724; or the nucleotide sequence of a mature protein coding sequence of clone ya9 — 1 deposited under accession number ATCC 98724. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ya9 — 1 deposited under accession number ATCC 98724. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:14 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:14, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:14 having biological activity, the fragment comprising the amino acid sequence from amino acid 86 to amino acid 95 of SEQ ID NO:14. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:13. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:13, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:13; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ya9 — 1 deposited under accession number ATCC 98724; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:13, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:13; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ya9 — 1 deposited under accession number ATCC 98724; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:13, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:13 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:13, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:13. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:13 from nucleotide 45 to nucleotide 590, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:13 from nucleotide 45 to nucleotide 590, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:13 from nucleotide 45 to nucleotide 590. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:13 from nucleotide 126 to nucleotide 590, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:13 from nucleotide 126 to nucleotide 590, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:13 from nucleotide 126 to nucleotide 590. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino add sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:14; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:14, the fragment comprising eight contiguous amino acids of SEQ ID NO:14; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ya9 — 1 deposited under accession number ATCC 98724; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:14. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:14 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:14, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:14 having biological activity, the fragment comprising the amino acid sequence from amino acid 86 to amino acid 95 of SEQ ID NO:14. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:15; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:15 from nucleotide 194 to nucleotide 466; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:15 from nucleotide 338 to nucleotide 466; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ya11 — 1 deposited under accession number ATCC 98724; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ya11 — 1 deposited under accession number ATCC 98724; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ya11 — 1 deposited under accession number ATCC 98724; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ya11 — 1 deposited under accession number ATCC 98724; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:16; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:16 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:16; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:15. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:15 from nucleotide 194 to nucleotide 466; the nucleotide sequence of SEQ ID NO:15 from nucleotide 338 to nucleotide 466; the nucleotide sequence of the full-length protein coding sequence of clone ya11 — 1 deposited under accession number ATCC 98724; or the nucleotide sequence of a mature protein coding sequence of clone ya11 — 1 deposited under accession number ATCC 98724. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ya11 — 1 deposited under accession number ATCC 98724. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:16 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:16, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:16 having biological activity, the fragment comprising the amino acid sequence from amino acid 40 to amino acid 49 of SEQ ID NO:16. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:15. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:15, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:15; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ya11 — 1 deposited under accession number ATCC 98724; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:15, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:15; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ya11 — 1 deposited under accession number ATCC 98724; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:15, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:15 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:15, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:15. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:15 from nucleotide 194 to nucleotide 466, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:15 from nucleotide 194 to nucleotide 466, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:15 from nucleotide 194 to nucleotide 466. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:15 from nucleotide 338 to nucleotide 466, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:15 from nucleotide 338 to nucleotide 466, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:15 from nucleotide 338 to nucleotide 466. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:16; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:16, the fragment comprising eight contiguous amino acids of SEQ ID NO:16; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ya11 — 1 deposited under accession number ATCC 98724; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:16. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:16 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:16, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:16 having biological activity, the fragment comprising the amino acid sequence from amino acid 40 to amino acid 49 of SEQ ID NO:16. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:17; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:17 from nucleotide 15 to nucleotide 233; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:17 from nucleotide 174 to nucleotide 233; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ya28 — 1 deposited under accession number ATCC 98724; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ya28 — 1 deposited under accession number ATCC 98724; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ya28 — 1 deposited under accession number ATCC 98724; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ya28 — 1 deposited under accession number ATCC 98724; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:18; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:18 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:18; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:17. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:17 from nucleotide 15 to nucleotide 233; the nucleotide sequence of SEQ ID NO:17 from nucleotide 174 to nucleotide 233; the nucleotide sequence of the full-length protein coding sequence of clone ya28 — 1 deposited under accession number ATCC 98724; or the nucleotide sequence of a mature protein coding sequence of clone ya28 — 1 deposited under accession number ATCC 98724. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ya28 — 1 deposited under accession number ATCC 98724. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:18 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:18, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:18 having biological activity, the fragment comprising the amino acid sequence from amino acid 31 to amino acid 40 of SEQ ID NO:18. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:17. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:17, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:17; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ya28 — 1 deposited under accession number ATCC 98724; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:17, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:17; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ya28 — 1 deposited under accession number ATCC 98724; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:17, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:17 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:17, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:17. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:17 from nucleotide 15 to nucleotide 233, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:17 from nucleotide 15 to nucleotide 233, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:17 from nucleotide 15 to nucleotide 233. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:17 from nucleotide 174 to nucleotide 233, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:17 from nucleotide 174 to nucleotide 233, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:17 from nucleotide 174 to nucleotide 233. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:18; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:18, the fragment comprising eight contiguous amino acids of SEQ ID NO:18; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ya28 — 1 deposited under accession number ATCC 98724; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:18. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:18 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:18, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:18 having biological activity, the fragment comprising the amino acid sequence from amino acid 31 to amino acid 40 of SEQ ID NO:18. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:19; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:19 from nucleotide 102 to nucleotide 461; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb81 — 1 deposited under accession number ATCC 98724; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb81 — 1 deposited under accession number ATCC 98724; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb81 — 1 deposited under accession number ATCC 98724; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb81 — 1 deposited under accession number ATCC 98724; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:20; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:20 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:20; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:19. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:19 from nucleotide 102 to nucleotide 461; the nucleotide sequence of the full-length protein coding sequence of clone yb81l1 deposited under accession number ATCC 98724; or the nucleotide sequence of a mature protein coding sequence of clone yb81l1 deposited under accession number ATCC 98724. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb81 — 1 deposited under accession number ATCC 98724. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:20 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:20, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:20 having biological activity, the fragment comprising the amino acid sequence from amino acid 55 to amino acid 64 of SEQ ID NO:20. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:19. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:19, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:19; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb81 — 1 deposited under accession number ATCC 98724; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:19, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:19; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb811 deposited under accession number ATCC 98724; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:19, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:19 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:19, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:19. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:19 from nucleotide 102 to nucleotide 461, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:19 from nucleotide 102 to nucleotide 461, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:19 from nucleotide 102 to nucleotide 461. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:20; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:20, the fragment comprising eight contiguous amino acids of SEQ ID NO:20; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb81 — 1 deposited under accession number ATCC 98724; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:20. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:20 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:20, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:20 having biological activity, the fragment comprising the amino acid sequence from amino acid 55 to amino acid 64 of SEQ ID NO:20. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:21; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:21 from nucleotide 170 to nucleotide 2968; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yc14 — 1 deposited under accession number ATCC 98724; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yc14 — 1 deposited under accession number ATCC 98724; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yc14 — 1 deposited under accession number ATCC 98724; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yc14 — 1 deposited under accession number ATCC 98724; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:22; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:22 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:22; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:21. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:21 from nucleotide 170 to nucleotide 2968; the nucleotide sequence of the full-length protein coding sequence of clone yc14 — 1 deposited under accession number ATCC 98724; or the nucleotide sequence of a mature protein coding sequence of clone yc14 — 1 deposited under accession number ATCC 98724. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yc14 — 1 deposited under accession number ATCC 98724. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:22 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:22, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:22 having biological activity, the fragment comprising the amino acid sequence from amino acid 461 to amino acid 470 of SEQ ID NO:22. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:21. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:21, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:21; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yc14 — 1 deposited under accession number ATCC 98724; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:21, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:21; and 
     (bb) the nucleotide sequence of the cDNA insert of done yc14 — 1 deposited under accession number ATCC 98724; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:21, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:21 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:21, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:21. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:21 from nucleotide 170 to nucleotide 2968, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:21 from nucleotide 170 to nucleotide 2968, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:21 from nucleotide 170 to nucleotide 2968. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:22; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:22, the fragment comprising eight contiguous amino acids of SEQ ID NO:22; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yc14 — 1 deposited under accession number ATCC 98724; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:22. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:22 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:22, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:22 having biological activity, the fragment comprising the amino acid sequence from amino acid 461 to amino acid 470 of SEQ ID NO:22. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:23; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:23 from nucleotide 82 to nucleotide 729; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yc24 — 1 deposited under accession number ATCC 98755; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yc24 — 1 deposited under accession number ATCC 98755; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yc24 — 1 deposited under accession number ATCC 98755; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yc24 — 1 deposited under accession number ATCC 98755; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:24; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:24 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:24; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:23. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:23 from nucleotide 82 to nucleotide 729; the nucleotide sequence of the full-length protein coding sequence of clone yc24 — 1 deposited under accession number ATCC 98755; or the nucleotide sequence of a mature protein coding sequence of clone yc24 — 1 deposited under accession number ATCC 98755. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yc24 — 1 deposited under accession number ATCC 98755. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:24 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:24, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:24 having biological activity, the fragment comprising the amino acid sequence from amino acid 103 to amino acid 112 of SEQ ID NO:24. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:23. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:23, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:23; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yc24 — 1 deposited under accession number ATCC 98755; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:23, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:23; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yc24 — 1 deposited under accession number ATCC 98755; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:23, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:23 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:23, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:23. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:23 from nucleotide 82 to nucleotide 729, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:23 from nucleotide 82 to nucleotide 729, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:23 from nucleotide 82 to nucleotide 729. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:24; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:24, the fragment comprising eight contiguous amino acids of SEQ ID NO:24; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yc24 — 1 deposited under accession number ATCC 98755; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:24. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:24 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:24, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:24 having biological activity, the fragment comprising the amino acid sequence from amino acid 103 to amino acid 112 of SEQ ID NO:24. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:25; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:25 from nucleotide 7 to nucleotide 951; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:25 from nucleotide 61 to nucleotide 951; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yc25 — 1 deposited under accession number ATCC 98755; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yc25 — 1 deposited under accession number ATCC 98755; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yc25 — 1 deposited under accession number ATCC 98755; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yc25 — 1 deposited under accession number ATCC 98755; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:26; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:26 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:26; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:25. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:25 from nucleotide 7 to nucleotide 951; the nucleotide sequence of SEQ ID NO:25 from nucleotide 61 to nucleotide 951; the nucleotide sequence of the full-length protein coding sequence of clone yc25 — 1 deposited under accession number ATCC 98755; or the nucleotide sequence of a mature protein coding sequence of clone yc25 — 1 deposited under accession number ATCC 98755. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yc25 — 1 deposited under accession number ATCC 98755. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:26 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:26, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:26 having biological activity, the fragment comprising the amino acid sequence from amino acid 152 to amino acid 161 of SEQ ID NO:26. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:25. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:25, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:25; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yc25 — 1 deposited under accession number ATCC 98755; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:25, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:25; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yc25 — 1 deposited under accession number ATCC 98755; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:25, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:25 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:25, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:25. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:25 from nucleotide 7 to nucleotide 951, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:25 from nucleotide 7 to nucleotide 951, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:25 from nucleotide 7 to nucleotide 951. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:25 from nucleotide 61 to nucleotide 951, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:25 from nucleotide 61 to nucleotide 951, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:25 from nucleotide 61 to nucleotide 951. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:26; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:26, the fragment comprising eight contiguous amino acids of SEQ ID NO:26; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yc25 — 1 deposited under accession number ATCC 98755; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:26. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:26 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:26, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:26 having biological activity, the fragment comprising the amino acid sequence from amino acid 152 to amino acid 161 of SEQ ID NO:26. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:27; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:27 from nucleotide 157 to nucleotide 1083; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ye2 — 1 deposited under accession number ATCC 98755; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ye2 — 1 deposited under accession number ATCC 98755; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ye2 — 1 deposited under accession number ATCC 98755; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ye2 — 1 deposited under accession number ATCC 98755; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:28; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:28 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:28; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:27. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:27 from nucleotide 157 to nucleotide 1083; the nucleotide sequence of the full-length protein coding sequence of clone ye2 — 1 deposited under accession number ATCC 98755; or the nucleotide sequence of a mature protein coding sequence of clone ye2 — 1 deposited under accession number ATCC 98755. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ye2 — 1 deposited under accession number ATCC 98755. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:28 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:28, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:28 having biological activity, the fragment comprising the amino acid sequence from amino acid 149 to amino acid 158 of SEQ ID NO:28. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:27. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:27, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:27; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ye2 — 1 deposited under accession number ATCC 98755; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:27, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:27; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ye2 — 1 deposited under accession number ATCC 98755; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:27, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:27 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:27, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:27. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:27 from nucleotide 157 to nucleotide 1083, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:27 from nucleotide 157 to nucleotide 1083, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:27 from nucleotide 157 to nucleotide 1083. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:28; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:28, the fragment comprising eight contiguous amino acids of SEQ ID NO:28; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ye2 — 1 deposited under accession number ATCC 98755; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:28. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:28 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:28, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:28 having biological activity, the fragment comprising the amino acid sequence from amino acid 149 to amino acid 158 of SEQ ID NO:28. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:29; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:29 from nucleotide 39 to nucleotide 473; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ya65 — 1 deposited under accession number ATCC 98834; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ya65 — 1 deposited under accession number ATCC 98834; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ya65 — 1 deposited under accession number ATCC 98834; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ya65 — 1 deposited under accession number ATCC 98834; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:30; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:30 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:30; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:29. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:29 from nucleotide 39 to nucleotide 473; the nucleotide sequence of the full-length protein coding sequence of clone ya65 — 1 deposited under accession number ATCC 98834; or the nucleotide sequence of a mature protein coding sequence of clone ya65 — 1 deposited under accession number ATCC 98834. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ya65 — 1 deposited under accession number ATCC 98834. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:30 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:30, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:30 having biological activity, the fragment comprising the amino acid sequence from amino acid 67 to amino acid 76 of SEQ ID NO:30. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:29. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:29, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:29; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ya65 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:29, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:29; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ya65 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:29, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:29 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:29, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:29. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:29 from nucleotide 39 to nucleotide 473, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:29 from nucleotide 39 to nucleotide 473, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:29 from nucleotide 39 to nucleotide 473. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:30; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:30, the fragment comprising eight contiguous amino acids of SEQ ID NO:30; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ya65 — 1 deposited under accession number ATCC 98834; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:30. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:30 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:30, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:30 having biological activity, the fragment comprising the amino acid sequence from amino acid 67 to amino acid 76 of SEQ ID NO:30. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:31; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:31 from nucleotide 664 to nucleotide 903; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb60 — 1 deposited under accession number ATCC 98834; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb60 — 1 deposited under accession number ATCC 98834; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb60 — 1 deposited under accession number ATCC 98834; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb60 — 1 deposited under accession number ATCC 98834; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:32; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:32 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:32; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:31. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:31 from nucleotide 664 to nucleotide 903; the nucleotide sequence of the full-length protein coding sequence of clone yb60 — 1 deposited under accession number ATCC 98834; or the nucleotide sequence of a mature protein coding sequence of clone yb60 — 1 deposited under accession number ATCC 98834. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb60 — 1 deposited under accession number ATCC 98834. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:32 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:32, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:32 having biological activity, the fragment comprising the amino acid sequence from amino acid 35 to amino acid 44 of SEQ ID NO:32. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:31. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:31, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:31; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb60 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:31, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:31; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb60 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:31, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:31 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:31, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:31. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:31 from nucleotide 664 to nucleotide 903, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:31 from nucleotide 664 to nucleotide 903, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:31 from nucleotide 664 to nucleotide 903. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:32; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:32, the fragment comprising eight contiguous amino acids of SEQ ID NO:32; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb60 — 1 deposited under accession number ATCC 98834; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:32. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:32 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:32, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:32 having biological activity, the fragment comprising the amino acid sequence from amino acid 35 to amino acid 44 of SEQ ID NO:32. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:33; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:33 from nucleotide 88 to nucleotide 447; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:33 from nucleotide 427 to nucleotide 447; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb139 — 1 deposited under accession number ATCC 98834; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb139 — 1 deposited under accession number ATCC 98834; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb139 — 1 deposited under accession number ATCC 98834; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb139 — 1 deposited under accession number ATCC 98834; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:34; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:34 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:34; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:33. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:33 from nucleotide 88 to nucleotide 447; the nucleotide sequence of SEQ ID NO:33 from nucleotide 427 to nucleotide 447; the nucleotide sequence of the full-length protein coding sequence of clone yb139 — 1 deposited under accession number ATCC 98834; or the nucleotide sequence of a mature protein coding sequence of clone yb139 — 1 deposited under accession number ATCC 98834. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb139 — 1 deposited under accession number ATCC 98834. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:34 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:34, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:34 having biological activity, the fragment comprising the amino acid sequence from amino acid 55 to amino acid 64 of SEQ ID NO:34. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:33. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:33, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:33; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb139 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:33, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:33; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb139 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:33, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:33 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:33, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:33. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:33 from nucleotide 88 to nucleotide 447, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:33 from nucleotide 88 to nucleotide 447, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:33 from nucleotide 88 to nucleotide 447. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:33 from nucleotide 427 to nucleotide 447, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:33 from nucleotide 427 to nucleotide 447, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:33 from nucleotide 427 to nucleotide 447. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:34; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:34, the fragment comprising eight contiguous amino acids of SEQ ID NO:34; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb139 — 1 deposited under accession number ATCC 98834; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:34. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:34 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:34, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:34 having biological activity, the fragment comprising the amino acid sequence from amino acid 55 to amino acid 64 of SEQ ID NO:34. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:35; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:35 from nucleotide 93 to nucleotide 1481; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yc29 — 1 deposited under accession number ATCC 98834; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yc29 — 1 deposited under accession number ATCC 98834; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yc29 — 1 deposited under accession number ATCC 98834; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yc29 — 1 deposited under accession number ATCC 98834; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:36; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:36 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:36; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:35. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:35 from nucleotide 93 to nucleotide 1481; the nucleotide sequence of the full-length protein coding sequence of done yc29 — 1 deposited under accession number ATCC 98834; or the nucleotide sequence of a mature protein coding sequence of clone yc29 — 1 deposited under accession number ATCC 98834. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yc29 — 1 deposited under accession number ATCC 98834. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:36 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:36, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:36 having biological activity, the fragment comprising the amino acid sequence from amino acid 226 to amino acid 235 of SEQ ID NO:36. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:35. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:35, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:35; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yc29 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:35, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:35; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yc29 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:35, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:35 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:35, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:35. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:35 from nucleotide 93 to nucleotide 1481, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:35 from nucleotide 93 to nucleotide 1481, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:35 from nucleotide 93 to nucleotide 1481. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:36; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:36, the fragment comprising eight contiguous amino acids of SEQ ID NO:36; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yc29 — 1 deposited under accession number ATCC 98834; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:36. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:36 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:36, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:36 having biological activity, the fragment comprising the amino acid sequence from amino acid 226 to amino acid 235 of SEQ ID NO:36. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:37; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:37 from nucleotide 482 to nucleotide 751; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:37 from nucleotide 611 to nucleotide 751; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yc40 — 1 deposited under accession number ATCC 98834; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yc40 — 1 deposited under accession number ATCC 98834; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yc40 — 1 deposited under accession number ATCC 98834; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yc40 — 1 deposited under accession number ATCC 98834; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:38; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:38 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:38; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:37. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:37 from nucleotide 482 to nucleotide 751; the nucleotide sequence of SEQ ID NO:37 from nucleotide 611 to nucleotide 751; the nucleotide sequence of the full-length protein coding sequence of clone yc40 — 1 deposited under accession number ATCC 98834; or the nucleotide sequence of a mature protein coding sequence of clone yc40 — 1 deposited under accession number ATCC 98834. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yc40 — 1 deposited under accession number ATCC 98834. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:38 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:38, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:38 having biological activity, the fragment comprising the amino acid sequence from amino acid 40 to amino acid 49 of SEQ ID NO:38. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:37. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:37, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:37; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yc40 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:37, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:37; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yc40 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:37, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:37 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:37, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:37. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:37 from nucleotide 482 to nucleotide 751, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:37 from nucleotide 482 to nucleotide 751, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:37 from nucleotide 482 to nucleotide 751. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:37 from nucleotide 611 to nucleotide 751, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:37 from nucleotide 611 to nucleotide 751, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:37 from nucleotide 611 to nucleotide 751. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:38; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:38, the fragment comprising eight contiguous amino acids of SEQ ID NO:38; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yc40 — 1 deposited under accession number ATCC 98834; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:38. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:38 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:38, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:38 having biological activity, the fragment comprising the amino acid sequence from amino acid 40 to amino acid 49 of SEQ ID NO:38. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:39; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:39 from nucleotide 179 to nucleotide 601; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:39 from nucleotide 356 to nucleotide 601; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd10 — 1 deposited under accession number ATCC 98834; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd10 — 1 deposited under accession number ATCC 98834; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd10 — 1 deposited under accession number ATCC 98834; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd10 — 1 deposited under accession number ATCC 98834; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:40; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:40 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:40; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:39. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:39 from nucleotide 179 to nucleotide 601; the nucleotide sequence of SEQ ID NO:39 from nucleotide 356 to nucleotide 601; the nucleotide sequence of the full-length protein coding sequence of clone yd10 — 1 deposited under accession number ATCC 98834; or the nucleotide sequence of a mature protein coding sequence of clone yd10 — 1 deposited under accession number ATCC 98834. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd10 — 1 deposited under accession number ATCC 98834. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:40 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:40, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:40 having biological activity, the fragment comprising the amino acid sequence from amino acid 65 to amino acid 74 of SEQ ID NO:40. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:39. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:39, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:39; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd10 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:39, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:39; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd10 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:39, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:39 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:39, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:39. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:39 from nucleotide 179 to nucleotide 601, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:39 from nucleotide 179 to nucleotide 601, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:39 from nucleotide 179 to nucleotide 601. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:39 from nucleotide 356 to nucleotide 601, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:39 from nucleotide 356 to nucleotide 601, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:39 from nucleotide 356 to nucleotide 601. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:40; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:40, the fragment comprising eight contiguous amino acids of SEQ ID NO:40; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd10 — 1 deposited under accession number ATCC 98834; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:40. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:40 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:40, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:40 having biological activity, the fragment comprising the amino acid sequence from amino acid 65 to amino acid 74 of SEQ ID NO:40. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:41; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:41 from nucleotide 324 to nucleotide 1559; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:41 from nucleotide 387 to nucleotide 1559; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yf5 — 1 deposited under accession number ATCC 98834; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yf5 — 1 deposited under accession number ATCC 98834; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yf5 — 1 deposited under accession number ATCC 98834; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yf5 — 1 deposited under accession number ATCC 98834; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:42; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:42 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:42; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:41. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:41 from nucleotide 324 to nucleotide 1559; the nucleotide sequence of SEQ ID NO:41 from nucleotide 387 to nucleotide 1559; the nucleotide sequence of the full-length protein coding sequence of clone yf5 — 1 deposited under accession number ATCC 98834; or the nucleotide sequence of a mature protein coding sequence of clone yf5 — 1 deposited under accession number ATCC 98834. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yf5 — 1 deposited under accession number ATCC 98834. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:42 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:42, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:42 having biological activity, the fragment comprising the amino acid sequence from amino acid 201 to amino acid 210 of SEQ ID NO:42. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:41. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:41, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:41; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yf5 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:41, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:41; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yf5 — 1 deposited under accession number ATCC 98834; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:41, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:41 to a nucleotide sequence corresponding to the 3′ end of SEQ ID. NO:41, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:41. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:41 from nucleotide 324 to nucleotide 1559, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:41 from nucleotide 324 to nucleotide 1559, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:41 from nucleotide 324 to nucleotide 1559. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:41 from nucleotide 387 to nucleotide 1559, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:41 from nucleotide 387 to nucleotide 1559, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:41 from nucleotide 387 to nucleotide 1559. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:42; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:42, the fragment comprising eight contiguous amino acids of SEQ ID NO:42; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yf5 — 1 deposited under accession number ATCC 98834; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:42. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:42 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:42, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:42 having biological activity, the fragment comprising the amino acid sequence from amino acid 201 to amino acid 210 of SEQ ID NO:42. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:43; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:43 from nucleotide 257 to nucleotide 649; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:43 from nucleotide 335 to nucleotide 649; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ya67 — 1 deposited under accession number ATCC 98864; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ya67 — 1 deposited under accession number ATCC 98864; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ya67 — 1 deposited under accession number ATCC 98864; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ya67 — 1 deposited under accession number ATCC 98864; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:44; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:44 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:44; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:43. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:43 from nucleotide 257 to nucleotide 649; the nucleotide sequence of SEQ ID NO:43 from nucleotide 335 to nucleotide 649; the nucleotide sequence of the full-length protein coding sequence of done ya67 — 1 deposited under accession number ATCC 98864; or the nucleotide sequence of a mature protein coding sequence of clone ya67 — 1 deposited under accession number ATCC 98864. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ya67 — 1 deposited under accession number ATCC 98864. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:44 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:44, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:44 having biological activity, the fragment comprising the amino acid sequence from amino acid 60 to amino acid 69 of SEQ ID NO:44. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:43. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:43, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:43; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ya67 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:43, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:43; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ya67 — 1 deposited under accession number ATCC 98864; 
     (j) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:43, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:43 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:43, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:43. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:43 from nucleotide 257 to nucleotide 649, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:43 from nucleotide 257 to nucleotide 649, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:43 from nucleotide 257 to nucleotide 649. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:43 from nucleotide 335 to nucleotide 649, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:43 from nucleotide 335 to nucleotide 649, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:43 from nucleotide 335 to nucleotide 649. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:44; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:44, the fragment comprising eight contiguous amino acids of SEQ ID NO:44; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ya67 — 1 deposited under accession number ATCC 98864; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:44. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:44 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:44, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:44 having biological activity, the fragment comprising the amino acid sequence from amino acid 60 to amino acid 69 of SEQ ID NO:44. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:45; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:45 from nucleotide 89 to nucleotide 787; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ya70 — 1 deposited under accession number ATCC 98864; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ya70 — 1 deposited under accession number ATCC 98864; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ya70 — 1 deposited under accession number ATCC 98864; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ya70 — 1 deposited under accession number ATCC 98864; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:46; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:46 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:46; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:45. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:45 from nucleotide 89 to nucleotide 787; the nucleotide sequence of the full-length protein coding sequence of clone ya70 — 1 deposited under accession number ATCC 98864; or the nucleotide sequence of a mature protein coding sequence of clone ya70 — 1 deposited under accession number ATCC 98864. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ya70 — 1 deposited under accession number ATCC 98864. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:46 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:46, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:46 having biological activity, the fragment comprising the amino acid sequence from amino acid 111 to amino acid 120 of SEQ ID NO:46. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:45. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:45, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:45; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ya70 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:45, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:45; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ya70 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:45, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:45 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:45, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:45. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:45 from nucleotide 89 to nucleotide 787, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:45 from nucleotide 89 to nucleotide 787, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:45 from nucleotide 89 to nucleotide 787. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:46; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:46, the fragment comprising eight contiguous amino acids of SEQ ID NO:46; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ya70 — 1 deposited under accession number ATCC 98864; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:46. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:46 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:46, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:46 having biological activity, the fragment comprising the amino acid sequence from amino acid 111 to amino acid 120 of SEQ ID NO:46. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:47; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:47 from nucleotide 1017 to nucleotide 1265; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:47 from nucleotide 1068 to nucleotide 1265; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb51 — 1 deposited under accession number ATCC 98864; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb51 — 1 deposited under accession number ATCC 98864; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb51 — 1 deposited under accession number ATCC 98864; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb51 — 1 deposited under accession number ATCC 98864; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:48; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:48 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:48; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:47. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:47 from nucleotide 1017 to nucleotide 1265; the nucleotide sequence of SEQ ID NO:47 from nucleotide 1068 to nucleotide 1265; the nucleotide sequence of the full-length protein coding sequence of clone yb51 — 1 deposited under accession number ATCC 98864; or the nucleotide sequence of a mature protein coding sequence of clone yb51 — 1 deposited under accession number ATCC 98864. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb51 — 1 deposited under accession number ATCC 98864. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:48 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:48, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:48 having biological activity, the fragment comprising the amino acid sequence from amino acid 36 to amino acid 45 of SEQ ID NO:48. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:47. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:47, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:47; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb51 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:47, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:47; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb51 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:47, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:47 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:47, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:47. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:47 from nucleotide 1017 to nucleotide 1265, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:47 from nucleotide 1017 to nucleotide 1265, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:47 from nucleotide 1017 to nucleotide 1265. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:47 from nucleotide 1068 to nucleotide 1265, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:47 from nucleotide 1068 to nucleotide 1265, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:47 from nucleotide 1068 to nucleotide 1265. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:48; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:48, the fragment comprising eight contiguous amino acids of SEQ ID NO:48; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb51 — 1 deposited under accession number ATCC 98864; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:48. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:48 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:48, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:48 having biological activity, the fragment comprising the amino acid sequence from amino acid 36 to amino acid 45 of SEQ ID NO:48. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:49; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:49 from nucleotide 13 to nucleotide 306; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb101 — 1 deposited under accession number ATCC 98864; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb101 — 1 deposited under accession number ATCC 98864; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb101 — 1 deposited under accession number ATCC 98864; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb101 — 1 deposited under accession number ATCC 98864; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:50; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:50 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:50; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:49. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:49 from nucleotide 13 to nucleotide 306; the nucleotide sequence of the full-length protein coding sequence of clone yb101 — 1 deposited under accession number ATCC 98864; or the nucleotide sequence of a mature protein coding sequence of clone yb101 — 1 deposited under accession number ATCC 98864. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb101 — 1 deposited under accession number ATCC 98864. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:50 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:50, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:50 having biological activity, the fragment comprising the amino acid sequence from amino acid 44 to amino acid 53 of SEQ ID NO:50. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:49. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:49, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:49; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb101 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:49, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:49; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb101 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:49, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:49 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:49, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:49. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:49 from nucleotide 13 to nucleotide 306, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:49 from nucleotide 13 to nucleotide 306, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:49 from nucleotide 13 to nucleotide 306. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino add sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:50; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:50, the fragment comprising eight contiguous amino acids of SEQ ID NO:50; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb101 — 1 deposited under accession number ATCC 98864; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino add sequence of SEQ ID NO:50. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino add sequence of SEQ ID NO:50 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:50, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:50 having biological activity, the fragment comprising the amino acid sequence from amino acid 44 to amino acid 53 of SEQ ID NO:50. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:51; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:51 from nucleotide 284 to nucleotide 706; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb124 — 1 deposited under accession number ATCC 98864; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb124 — 1 deposited under accession number ATCC 98864; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb124 — 1 deposited under accession number ATCC 98864; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb124 — 1 deposited under accession number ATCC 98864; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:52; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:52 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:52; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:51. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:51 from nucleotide 284 to nucleotide 706; the nucleotide sequence of the full-length protein coding sequence of clone yb124 — 1 deposited under accession number ATCC 98864; or the nucleotide sequence of a mature protein coding sequence of clone yb124 — 1 deposited under accession number ATCC 98864. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb124 — 1 deposited under accession number ATCC 98864. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:52 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:52, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:52 having biological activity, the fragment comprising the amino acid sequence from amino acid 65 to amino acid 74 of SEQ ID NO:52. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:51. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:51, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:51; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb124 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:51, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:51; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb124 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:51, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:51 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:51, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:51. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:51 from nucleotide 284 to nucleotide 706, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:51 from nucleotide 284 to nucleotide 706, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:51 from nucleotide 284 to nucleotide 706. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:52; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:52, the fragment comprising eight contiguous amino acids of SEQ ID NO:52; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb124 — 1 deposited under accession number ATCC 98864; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:52. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:52 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:52, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:52 having biological activity, the fragment comprising the amino acid sequence from amino acid 65 to amino acid 74 of SEQ ID NO:52. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:53; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:53 from nucleotide 1106 to nucleotide 1447; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:53 from nucleotide 1187 to nucleotide 1447; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb125 — 1 deposited under accession number ATCC 98864; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb125 — 1 deposited under accession number ATCC 98864; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb125 — 1 deposited under accession number ATCC 98864; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb125 — 1 deposited under accession number ATCC 98864; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:54; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:54 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:54; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:53. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:53 from nucleotide 1106 to nucleotide 1447; the nucleotide sequence of SEQ ID NO:53 from nucleotide 1187 to nucleotide 1447; the nucleotide sequence of the full-length protein coding sequence of clone yb125 — 1 deposited under accession number ATCC 98864; or the nucleotide sequence of a mature protein coding sequence of clone yb125 — 1 deposited under accession number ATCC 98864. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb125 — 1 deposited under accession number ATCC 98864. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:54 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:54, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:54 having biological activity, the fragment comprising the amino acid sequence from amino acid 52 to amino acid 61 of SEQ ID NO:54. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:53. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:53, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:53; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb125 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:53, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:53; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb125 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:53, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:53 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:53, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:53. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:53 from nucleotide 1106 to nucleotide 1447, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:53 from nucleotide 1106 to nucleotide 1447, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:53 from nucleotide 1106 to nucleotide 1447. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:53 from nucleotide 1187 to nucleotide 1447, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:53 from nucleotide 1187 to nucleotide 1447, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:53 from nucleotide 1187 to nucleotide 1447. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:54; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:54, the fragment comprising eight contiguous amino acids of SEQ ID NO:54; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb125 — 1 deposited under accession number ATCC 98864; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:54. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:54 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:54, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:54 having biological activity, the fragment comprising the amino acid sequence from amino acid 52 to amino acid 61 of SEQ ID NO:54. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:55; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:55 from nucleotide 28 to nucleotide 417; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb179 — 1 deposited under accession number ATCC 98864; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb179 — 1 deposited under accession number ATCC 98864; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb179 — 1 deposited under accession number ATCC 98864; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb179 — 1 deposited under accession number ATCC 98864; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:56; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:56 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:56; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:55. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:55 from nucleotide 28 to nucleotide 417; the nucleotide sequence of the full-length protein coding sequence of clone yb179 — 1 deposited under accession number ATCC 98864; or the nucleotide sequence of a mature protein coding sequence of clone yb179 — 1 deposited under accession number ATCC 98864. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb179 — 1 deposited under accession number ATCC 98864. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:56 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:56, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:56 having biological activity, the fragment comprising the amino acid sequence from amino acid 60 to amino acid 69 of SEQ ID NO:56. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:55. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:55, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:55; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb179 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:55, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:55; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb179 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:55, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:55 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:55, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:55. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:55 from nucleotide 28 to nucleotide 417, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:55 from nucleotide 28 to nucleotide 417, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:55 from nucleotide 28 to nucleotide 417. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:56; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:56, the fragment comprising eight contiguous amino acids of SEQ ID NO:56; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb179 — 1 deposited under accession number ATCC 98864; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:56. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:56 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:56, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:56 having biological activity, the fragment comprising the amino acid sequence from amino acid 60 to amino acid 69 of SEQ ID NO:56. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:57; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:57 from nucleotide 56 to nucleotide 1084; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:57 from nucleotide 107 to nucleotide 1084; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yc48 — 1 deposited under accession number ATCC 98864; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yc48 — 1 deposited under accession number ATCC 98864; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yc48 — 1 deposited under accession number ATCC 98864; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yc48 — 1 deposited under accession number ATCC 98864; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:58; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:58 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:58; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:57. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:57 from nucleotide 56 to nucleotide 1084; the nucleotide sequence of SEQ ID NO:57 from nucleotide 107 to nucleotide 1084; the nucleotide sequence of the full-length protein coding sequence of clone yc48 — 1 deposited under accession number ATCC 98864; or the nucleotide sequence of a mature protein coding sequence of clone yc48 — 1 deposited under accession number ATCC 98864. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yc48 — 1 deposited under accession number ATCC 98864. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:58 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:58, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:58 having biological activity, the fragment comprising the amino acid sequence from amino acid 166 to amino acid 175 of SEQ ID NO:58. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:57. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:57, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:57; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yc48 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:57, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:57; and 
     (bb) the nucleotide sequence of the cDNA insert of done yc48 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (ii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:57, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:57 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:57, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:57. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:57 from nucleotide 56 to nucleotide 1084, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:57 from nucleotide 56 to nucleotide 1084, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:57 from nucleotide 56 to nucleotide 1084. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:57 from nucleotide 107 to nucleotide 1084, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:57 from nucleotide 107 to nucleotide 1084, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ. ID NO:57 from nucleotide 107 to nucleotide 1084. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:58; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:58, the fragment comprising eight contiguous amino acids of SEQ ID NO:58; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yc48 — 1 deposited under accession number ATCC 98864; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:58. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:58 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:58, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:58 having biological activity, the fragment comprising the amino acid sequence from amino acid 166 to amino acid 175 of SEQ ID NO:58. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:59; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:59 from nucleotide 373 to nucleotide 660; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:59 from nucleotide 436 to nucleotide 660; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ye21 — 1 deposited under accession number ATCC 98864; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ye21 — 1 deposited under accession number ATCC 98864; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ye21 — 1 deposited under accession number ATCC 98864; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ye21 — 1 deposited under accession number ATCC 98864; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:60; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:60 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:60; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:59. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:59 from nucleotide 373 to nucleotide 660; the nucleotide sequence of SEQ ID NO:59 from nucleotide 436 to nucleotide 660; the nucleotide sequence of the full-length protein coding sequence of clone ye21 — 1 deposited under accession number ATCC 98864; or the nucleotide sequence of a mature protein coding sequence of clone ye21 — 1 deposited under accession number ATCC 98864. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ye21 — 1 deposited under accession number ATCC 98864. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:60 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:60, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:60 having biological activity, the fragment comprising the amino acid sequence from amino acid 43 to amino acid 52 of SEQ ID NO:60. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:59. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:59, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:59; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ye21 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:59, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:59; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ye21 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:59, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:59 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:59, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:59. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:59 from nucleotide 373 to nucleotide 660, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:59 from nucleotide 373 to nucleotide 660, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:59 from nucleotide 373 to nucleotide 660. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:59 from nucleotide 436 to nucleotide 660, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:59 from nucleotide 436 to nucleotide 660, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:59 from nucleotide 436 to nucleotide 660. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:60; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:60, the fragment comprising eight contiguous amino acids of SEQ ID NO:60; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ye21 — 1 deposited under accession number ATCC 98864; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:60. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:60 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:60, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:60 having biological activity, the fragment comprising the amino acid sequence from amino acid 43 to amino acid 52 of SEQ ID NO:60. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:61; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:61 from nucleotide 119 to nucleotide 466; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ye22 — 1 deposited under accession number ATCC 98864; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ye22 — 1 deposited under accession number ATCC 98864; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ye22 — 1 deposited under accession number ATCC 98864; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ye22 — 1 deposited under accession number ATCC 98864; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:62; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:62 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:62; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:61. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:61 from nucleotide 119 to nucleotide 466; the nucleotide sequence of the full-length protein coding sequence of clone ye22 — 1 deposited under accession number ATCC 98864; or the nucleotide sequence of a mature protein coding sequence of clone ye22 — 1 deposited under accession number ATCC 98864. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ye22 — 1 deposited under accession number ATCC 98864. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:62 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:62, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:62 having biological activity, the fragment comprising the amino acid sequence from amino acid 53 to amino acid 62 of SEQ ID NO:62. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:61. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:61, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:61; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ye22 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:61, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:61; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ye22 — 1 deposited under accession number ATCC 98864; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:61, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:61 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:61, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:61. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:61 from nucleotide 119 to nucleotide 466, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:61 from nucleotide 119 to nucleotide 466, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:61 from nucleotide 119 to nucleotide 466. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:62; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:62, the fragment comprising eight contiguous amino acids of SEQ ID NO:62; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ye22 — 1 deposited under accession number ATCC 98864; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:62. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:62 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:62, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:62 having biological activity, the fragment comprising the amino acid sequence from amino acid 53 to amino acid 62 of SEQ ID NO:62. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:63; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:63 from nucleotide 1212 to nucleotide 1502; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ye39 — 1 deposited under accession number ATCC 98861; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ye39 — 1 deposited under accession number ATCC 98861; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ye39 — 1 deposited under accession number ATCC 98861; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ye39 — 1 deposited under accession number ATCC 98861; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:64; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:64 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:64; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:63. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:63 from nucleotide 1212 to nucleotide 1502; the nucleotide sequence of the full-length protein coding sequence of clone ye39 — 1 deposited under accession number ATCC 98861; or the nucleotide sequence of a mature protein coding sequence of clone ye39 — 1 deposited under accession number ATCC 98861. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ye39 — 1 deposited under accession number ATCC 98861. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:64 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:64, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:64 having biological activity, the fragment comprising the amino acid sequence from amino acid 43 to amino acid 52 of SEQ ID NO:64. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:63. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:63, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:63; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ye39 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:63, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:63; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ye39 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:63, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:63 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:63, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:63. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:63 from nucleotide 1212 to nucleotide 1502, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:63 from nucleotide 1212 to nucleotide 1502, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:63 from nucleotide 1212 to nucleotide 1502. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:64; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:64, the fragment comprising eight contiguous amino acids of SEQ ID NO:64; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ye39 — 1 deposited under accession number ATCC 98861; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:64. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:64 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:64, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:64 having biological activity, the fragment comprising the amino acid sequence from amino acid 43 to amino acid 52 of SEQ ID NO:64. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:65; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:65 from nucleotide 81 to nucleotide 887; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yf9 — 1 deposited under accession number ATCC 98861; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yf9 — 1 deposited under accession number ATCC 98861; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yf9 — 1 deposited under accession number ATCC 98861; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yf9 — 1 deposited under accession number ATCC 98861; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:66; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:66 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:66; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:65. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:65 from nucleotide 81 to nucleotide 887; the nucleotide sequence of the full-length protein coding sequence of clone yf9 — 1 deposited under accession number ATCC 98861; or the nucleotide sequence of a mature protein coding sequence of clone yf9 — 1 deposited under accession number ATCC 98861. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yf9 — 1 deposited under accession number ATCC 98861. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:66 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:66, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:66 having biological activity, the fragment comprising the amino acid sequence from amino acid 129 to amino acid 138 of SEQ ID NO:66. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:65. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:65; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yf9 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:65; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yf9 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:65, land extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:65 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:65. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:65 from nucleotide 81 to nucleotide 887, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:65 from nucleotide 81 to nucleotide 887, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:65 from nucleotide 81 to nucleotide 887. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:66; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:66, the fragment comprising eight contiguous amino acids of SEQ ID NO:66; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yf9 — 1 deposited under accession number ATCC 98861; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:66. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:66 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:66, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:66 having biological activity, the fragment comprising the amino acid sequence from amino acid 129 to amino acid 138 of SEQ ID NO:66. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:67; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:67 from nucleotide 63 to nucleotide 305; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of done yh4 — 1 deposited under accession number ATCC 98861; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yh4 — 1 deposited under accession number ATCC 98861; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yh4 — 1 deposited under accession number ATCC 98861; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yh4 — 1 deposited under accession number ATCC 98861; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:68; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:68 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO 68; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:67. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:67 from nucleotide 63 to nucleotide 305; the nucleotide sequence of the full-length protein coding sequence of clone yh4 — 1 deposited under accession number ATCC 98861; or the nucleotide sequence of a mature protein coding sequence of clone yh4 — 1 deposited under accession number ATCC 98861. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yh4 — 1 deposited under accession number ATCC 98861. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:68 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:68, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:68 having biological activity, the fragment comprising the amino acid sequence from amino acid 35 to amino acid 44 of SEQ ID NO:68. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:67. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:67, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:67; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yh4 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:67, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:67; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yh4 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:67, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:67 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:67, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:67. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:67 from nucleotide 63 to nucleotide 305, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:67 from nucleotide 63 to nucleotide 305, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:67 from nucleotide 63 to nucleotide 305. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:68; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:68, the fragment comprising eight contiguous amino acids of SEQ ID NO:68; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yh4 — 1 deposited under accession number ATCC 98861; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:68. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:68 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:68, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:68 having biological activity, the fragment comprising the amino acid sequence from amino acid 35 to amino acid 44 of SEQ ID NO:68. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:69; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:69 from nucleotide 332 to nucleotide 685; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:69 from nucleotide 422 to nucleotide 685; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yi4 — 1 deposited under accession number ATCC 98861; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yi4 — 1 deposited under accession number ATCC 98861; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yi4 — 1 deposited under accession number ATCC 98861; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yi4 — 1 deposited under accession number ATCC 98861; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:70; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:70 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:70; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:69. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:69 from nucleotide 332 to nucleotide 685; the nucleotide sequence of SEQ ID NO:69 from nucleotide 422 to nucleotide 685; the nucleotide sequence of the full-length protein coding sequence of clone yi4 — 1 deposited under accession number ATCC 98861; or the nucleotide sequence of a mature protein coding sequence of clone yi4 — 1 deposited under accession number ATCC 98861. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yi4 — 1 deposited under accession number ATCC 98861. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:70 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:70, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:70 having biological activity, the fragment comprising the amino acid sequence from amino acid 54 to amino acid 63 of SEQ ID NO:70. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:69. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:69, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:69; and 
     (ab) the nucleotide sequence of the cDNA insert of done yi4 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:69, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:69; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yi4 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:69, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:69 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:69, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:69. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:69 from nucleotide 332 to nucleotide 685, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:69 from nucleotide 332 to nucleotide 685, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:69 from nucleotide 332 to nucleotide 685. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:69 from nucleotide 422 to nucleotide 685, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:69 from nucleotide 422 to nucleotide 685, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:69 from nucleotide 422 to nucleotide 685. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:70; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:70, the fragment comprising eight contiguous amino acids of SEQ ID NO:70; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yi4 — 1 deposited under accession number ATCC 98861; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:70. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:70 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:70, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:70 having biological activity, the fragment comprising the amino acid sequence from amino acid 54 to amino acid 63 of SEQ ID NO:70. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:71; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:71 from nucleotide 143 to nucleotide 502; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:71 from nucleotide 203 to nucleotide 502; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yj3 — 1 deposited under accession number ATCC 98861; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yj3 — 1 deposited under accession number ATCC 98861; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yj3 — 1 deposited under accession number ATCC 98861; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yj3 — 1 deposited under accession number ATCC 98861; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:72; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:72 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:72; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:71. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:71 from nucleotide 143 to nucleotide 502; the nucleotide sequence of SEQ ID NO:71 from nucleotide 203 to nucleotide 502; the nucleotide sequence of the full-length protein coding sequence of clone yj3 — 1 deposited under accession number ATCC 98861; or the nucleotide sequence of a mature protein coding sequence of clone yj3 — 1 deposited under accession number ATCC 98861. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yj3 — 1 deposited under accession number ATCC 98861. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:72 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:72, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:72 having biological activity, the fragment comprising the amino acid sequence from amino acid 55 to amino acid 64 of SEQ ID NO:72. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:71. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:71, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:71; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yj3 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:71, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:71; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yj3 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:71, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:71 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:71, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:71. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:71 from nucleotide 143 to nucleotide 502, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:71 from nucleotide 143 to nucleotide 502, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:71 from nucleotide 143 to nucleotide 502. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:71 from nucleotide 203 to nucleotide 502, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:71 from nucleotide 203 to nucleotide 502, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:71 from nucleotide 203 to nucleotide 502. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:72; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:72, the fragment comprising eight contiguous amino acids of SEQ ID NO:72; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yj3 — 1 deposited under accession number ATCC 98861; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:72. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:72 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:72, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:72 having biological activity, the fragment comprising the amino acid sequence from amino acid 55 to amino acid 64 of SEQ ID NO:72. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:73; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:73 from nucleotide 30 to nucleotide 1004; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:73 from nucleotide 129 to nucleotide 1004; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yj7 — 1 deposited under accession number ATCC 98861; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yj7 — 1 deposited under accession number ATCC 98861; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yj7 — 1 deposited under accession number ATCC 98861; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yj7 — 1 deposited under accession number ATCC 98861; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:74; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:74 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:74; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:73. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:73 from nucleotide 30 to nucleotide 1004; the nucleotide sequence of SEQ ID NO:73 from nucleotide 129 to nucleotide 1004; the nucleotide sequence of the full-length protein coding sequence of clone yj7 — 1 deposited under accession number ATCC 98861; or the nucleotide sequence of a mature protein coding sequence of clone yj7 — 1 deposited under accession number ATCC 98861. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yj7 — 1 deposited under accession number ATCC 98861. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:74 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:74, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:74 having biological activity, the fragment comprising the amino acid sequence from amino acid 157 to amino acid 166 of SEQ ID NO:74. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:73. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:73, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:73; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yj7 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:73, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:73; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yj7 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:73, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:73 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:73, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:73. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:73 from nucleotide 30 to nucleotide 1004, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:73 from nucleotide 30 to nucleotide 1004, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:73 from nucleotide 30 to nucleotide 1004. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:73 from nucleotide 129 to nucleotide 1004, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:73 from nucleotide 129 to nucleotide 1004, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:73 from nucleotide 129 to nucleotide 1004. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:74; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:74, the fragment comprising eight contiguous amino acids of SEQ ID NO:74; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yj7 — 1 deposited under accession number ATCC 98861; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:74. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:74 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:74, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:74 having biological activity, the fragment comprising the amino acid sequence from amino acid 157 to amino acid 166 of SEQ ID NO:74. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:75; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:75 from nucleotide 109 to nucleotide 1047; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yj10 — 1 deposited under accession number ATCC 98861; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yj10 — 1 deposited under accession number ATCC 98861; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yj10 — 1 deposited under accession number ATCC 98861; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yj10 — 1 deposited under accession number ATCC 98861; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:76; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:76 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:76; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:75. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:75 from nucleotide 109 to nucleotide 1047; the nucleotide sequence of the full-length protein coding sequence of done yj10 — 1 deposited under accession number ATCC 98861; or the nucleotide sequence of a mature protein coding sequence of clone yj10 — 1 deposited under accession number ATCC 98861. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yj10 — 1 deposited under accession number ATCC 98861. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:76 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:76, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:76 having biological activity, the fragment comprising the amino acid sequence from amino acid 151 to amino acid 160 of SEQ ID NO:76. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:75. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:75, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:75; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yj10 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:75, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:75; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yj10 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:75, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:75 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:75, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:75. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:75 from nucleotide 109 to nucleotide 1047, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:75 from nucleotide 109 to nucleotide 1047, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:75 from nucleotide 109 to nucleotide 1047. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:76; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:76, the fragment comprising eight contiguous amino acids of SEQ ID NO:76; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yj10 — 1 deposited under accession number ATCC 98861; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:76. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:76 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:76, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:76 having biological activity, the fragment comprising the amino acid sequence from amino acid 151 to amino acid 160 of SEQ ID NO:76. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:77; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:77 from nucleotide 42 to nucleotide 1196; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:77 from nucleotide 558 to nucleotide 1196; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yj28 — 1 deposited under accession number ATCC 98861; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yj28 — 1 deposited under accession number ATCC 98861; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yj28 — 1 deposited under accession number ATCC 98861; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yj28 — 1 deposited under accession number ATCC 98861; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:78; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:78 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:78; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:77. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:77 from nucleotide 42 to nucleotide 1196; the nucleotide sequence of SEQ ID NO:77 from nucleotide 558 to nucleotide 1196; the nucleotide sequence of the full-length protein coding sequence of clone yj28 — 1 deposited under accession number ATCC 98861; or the nucleotide sequence of a mature protein coding sequence of clone yj28 — 1 deposited under accession number ATCC 98861. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yj28 — 1 deposited under accession number ATCC 98861. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:78 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:78, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:78 having biological activity, the fragment comprising the amino acid sequence from amino acid 187 to amino acid 196 of SEQ ID NO:78. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:77. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:77, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:77; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yj28 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:77, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:77; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yj28 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:77, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:77 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:77, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:77. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:77 from nucleotide 42 to nucleotide 1196, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:77 from nucleotide 42 to nucleotide 1196, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:77 from nucleotide 42 to nucleotide 1196. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:77 from nucleotide 558 to nucleotide 1196, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:77 from nucleotide 558 to nucleotide 1196, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:77 from nucleotide 558 to nucleotide 1196. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:78; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:78, the fragment comprising eight contiguous amino acids of SEQ ID NO:78; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yj28 — 1 deposited under accession number ATCC 98861; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:78. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:78 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:78, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:78 having biological activity, the fragment comprising the amino acid sequence from amino acid 187 to amino acid 196 of SEQ ID NO:78. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:79; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:79 from nucleotide 29 to nucleotide 1156; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:79 from nucleotide 995 to nucleotide 1156; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yj29 — 1 deposited under accession number ATCC 98861; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yj29 — 1 deposited under accession number ATCC 98861; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of done yj29 — 1 deposited under accession number ATCC 98861; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yj29 — 1 deposited under accession number ATCC 98861; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:80; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:80 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:80; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:79. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:79 from nucleotide 29 to nucleotide 1156; the nucleotide sequence of SEQ ID NO:79 from nucleotide 995 to nucleotide 1156; the nucleotide sequence of the full-length protein coding sequence of clone yj29 — 1 deposited under accession number ATCC 98861; or the nucleotide sequence of a mature protein coding sequence of clone yj29 — 1 deposited under accession number ATCC 98861. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yj29 — 1 deposited under accession number ATCC 98861. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:80 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:80, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:80 having biological activity, the fragment comprising the amino acid sequence from amino acid 183 to amino acid 192 of SEQ ID NO:80. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:79. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:79, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:79; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yj29 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:79, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:79; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yj29 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:79, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:79 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:79, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:79. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:79 from nucleotide 29 to nucleotide 1156, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:79 from nucleotide 29 to nucleotide 1156, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:79 — 1 from nucleotide 29 to nucleotide 1156. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:79 from nucleotide 995 to nucleotide 1156, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:79 from nucleotide 995 to nucleotide 1156, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:79 from nucleotide 995 to nucleotide 1156. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:80; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:80, the fragment comprising eight contiguous amino acids of SEQ ID NO:80; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yj29 — 1 deposited under accession number ATCC 98861; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:80. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:80 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:80, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:80 having biological activity, the fragment comprising the amino acid sequence from amino acid 183 to amino acid 192 of SEQ ID NO:80. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:81; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:81 from nucleotide 93 to nucleotide 398; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:81 from nucleotide 321 to nucleotide 398; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yj32 — 1 deposited under accession number ATCC 98861; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yj32 — 1 deposited under accession number ATCC 98861; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yj32 — 1 deposited under accession number ATCC 98861; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yj32 — 1 deposited under accession number ATCC 98861; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:82; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:82 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:82; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:81. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:81 from nucleotide 93 to nucleotide 398; the nucleotide sequence of SEQ ID NO:81 from nucleotide 321 to nucleotide 398; the nucleotide sequence of the full-length protein coding sequence of clone yj32 — 1 deposited under accession number ATCC 98861; or the nucleotide sequence of a mature protein coding sequence of clone yj32 — 1 deposited under accession number ATCC 98861. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yj32 — 1 deposited under accession number ATCC 98861. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:82 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:82, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:82 having biological activity, the fragment comprising the amino acid sequence from amino acid 46 to amino acid 55 of SEQ ID NO:82. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:81. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:81, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:81; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yj32 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:81, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:81; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yj32 — 1 deposited under accession number ATCC 98861; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:81, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:81 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:81, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:81. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:81 from nucleotide 93 to nucleotide 398, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:81 from nucleotide 93 to nucleotide 398, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:81 from nucleotide 93 to nucleotide 398. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:81 from nucleotide 321 to nucleotide 398, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:81 from nucleotide 321 to nucleotide 398, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:81 from nucleotide 321 to nucleotide 398. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:82; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:82, the fragment comprising eight contiguous amino acids of SEQ ID NO:82; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yj32 — 1 deposited under accession number ATCC 98861; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:82. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:82 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:82, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:82 having biological activity, the fragment comprising the amino acid sequence from amino acid 46 to amino acid 55 of SEQ ID NO:82. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:83; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:83 from nucleotide 167 to nucleotide 1264; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:83 from nucleotide 233 to nucleotide 1264; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb186 — 1 deposited under accession number ATCC 98872; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb186 — 1 deposited under accession number ATCC 98872; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb186 — 1 deposited under accession number ATCC 98872; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb186 — 1 deposited under accession number ATCC 98872; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:84; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:84 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:84; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:83. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:83 from nucleotide 167 to nucleotide 1264; the nucleotide sequence of SEQ ID NO:83 from nucleotide 233 to nucleotide 1264; the nucleotide sequence of the full-length protein coding sequence of clone yb186 — 1 deposited under accession number ATCC 98872; or the nucleotide sequence of a mature protein coding sequence of clone yb186 — 1 deposited under accession number ATCC 98872. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb186 — 1 deposited under accession number ATCC 98872. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:84 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:84, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:84 having biological activity, the fragment comprising the amino acid sequence from amino acid 178 to amino acid 187 of SEQ ID NO:84. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:83. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:83, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:83; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb186 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:83, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:83; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb186 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:83, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:83 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:83, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:83. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:83 from nucleotide 167 to nucleotide 1264, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:83 from nucleotide 167 to nucleotide 1264, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:83 from nucleotide 167 to nucleotide 1264. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:83 from nucleotide 233 to nucleotide 1264, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:83 from nucleotide 233 to nucleotide 1264, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:83 from nucleotide 233 to nucleotide 1264. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:84; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:84, the fragment comprising eight contiguous amino acids of SEQ ID NO:84; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb186 — 1 deposited under accession number ATCC 98872; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:84. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:84 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:84, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:84 having biological activity, the fragment comprising the amino acid sequence from amino acid 178 to amino acid 187 of SEQ ID NO:84. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:85; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:85 from nucleotide 832 to nucleotide 1416; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb226 — 1 deposited under accession number ATCC 98872; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb226 — 1 deposited under accession number ATCC 98872; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb226 — 1 deposited under accession number ATCC 98872; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb226 — 1 deposited under accession number ATCC 98872; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:86; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:86 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:86; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:85. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:85 from nucleotide 832 to nucleotide 1416; the nucleotide sequence of the full-length protein coding sequence of clone yb226 — 1 deposited under accession number ATCC 98872; or the nucleotide sequence of a mature protein coding sequence of clone yb226 — 1 deposited under accession number ATCC 98872. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb226 — 1 deposited under accession number ATCC 98872. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:86 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:86, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:86 having biological activity, the fragment comprising the amino acid sequence from amino acid 92 to amino acid 101 of SEQ ID NO:86. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:85. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:85, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:85; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb226 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:85, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:85; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb226 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:85, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:85 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:85, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:85. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:85 from nucleotide 832 to nucleotide 1416, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:85 from nucleotide 832 to nucleotide 1416, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:85 from nucleotide 832 to nucleotide 1416. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:86; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:86, the fragment comprising eight contiguous amino acids of SEQ ID NO:86; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb226 — 1 deposited under accession number ATCC 98872; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:86. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:86 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:86, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:86 having biological activity, the fragment comprising the amino acid sequence from amino acid 92 to amino acid 101 of SEQ ID NO:86. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:87; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:87 from nucleotide 155 to nucleotide 745; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd50 — 1 deposited under accession number ATCC 98872; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd50 — 1 deposited under accession number ATCC 98872; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd50 — 1 deposited under accession number ATCC 98872; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd50 — 1 deposited under accession number ATCC 98872; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:88; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:88 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:88; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:87. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:87 from nucleotide 155 to nucleotide 745; the nucleotide sequence of the full-length protein coding sequence of clone yd50 — 1 deposited under accession number ATCC 98872; or the nucleotide sequence of a mature protein coding sequence of clone yd50 — 1 deposited under accession number ATCC 98872. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd50 — 1 deposited under accession number ATCC 98872. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:88 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:88, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:88 having biological activity, the fragment comprising the amino acid sequence from amino acid 93 to amino acid 102 of SEQ ID NO:88. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:87. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:87, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:87; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd50 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:87, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:87; and 
     (bb) the nucleotide sequence of the cDNA insert of done yd50 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:87, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:87 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:87, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:87. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:87 from nucleotide 155 to nucleotide 745, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:87 from nucleotide 155 to nucleotide 745, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:87 from nucleotide 155 to nucleotide 745. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:88; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:88, the fragment comprising eight contiguous amino acids of SEQ ID NO:88; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd50 — 1 deposited under accession number ATCC 98872; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:88. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:88 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:88, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:88 having biological activity, the fragment comprising the amino acid sequence from amino acid 93 to amino acid 102 of SEQ ID NO:88. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:89; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:89 from nucleotide 42 to nucleotide 317; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:89 from nucleotide 111 to nucleotide 317; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd51 — 1 deposited under accession number ATCC 98872; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd51 — 1 deposited under accession number ATCC 98872; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd51 — 1 deposited under accession number ATCC 98872; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd51 — 1 deposited under accession number ATCC 98872; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:90; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:90 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:90; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:89. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:89 from nucleotide 42 to nucleotide 317; the nucleotide sequence of SEQ ID NO:89 from nucleotide 111 to nucleotide 317; the nucleotide sequence of the full-length protein coding sequence of clone yd51 — 1 deposited under accession number ATCC 98872; or the nucleotide sequence of a mature protein coding sequence of clone yd51 — 1 deposited under accession number ATCC 98872. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd51 — 1 deposited under accession number ATCC 98872. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:90 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:90, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:90 having biological activity, the fragment comprising the amino acid sequence from amino acid 41 to amino acid 50 of SEQ ID NO:90. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:89. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:89, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:89; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd51 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:89, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:89; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd51 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:89, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:89 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:89, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:89. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:89 from nucleotide 42 to nucleotide 317, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:89 from nucleotide 42 to nucleotide 317, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:89 from nucleotide 42 to nucleotide 317. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:89 from nucleotide 111 to nucleotide 317, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:89 from nucleotide 111 to nucleotide 317, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:89 from nucleotide 111 to nucleotide 317. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:90; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:90; the fragment comprising eight contiguous amino acids of SEQ ID NO:90; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd51 — 1 deposited under accession number ATCC 98872; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:90. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:90 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:90, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:90 having biological activity, the fragment comprising the amino acid sequence from amino acid 41 to amino acid 50 of SEQ ID NO:90. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:91; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:91 from nucleotide 7 to nucleotide 603; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:91 from nucleotide 244 to nucleotide 603; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd73 — 1 deposited under accession number ATCC 98872; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd73 — 1 deposited under accession number ATCC 98872; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd73 — 1 deposited under accession number ATCC 98872; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd73 — 1 deposited under accession number ATCC 98872; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:92; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:92 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:92; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:91. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:91 from nucleotide 7 to nucleotide 603; the nucleotide sequence of SEQ ID NO:91 from nucleotide 244 to nucleotide 603; the nucleotide sequence of the full-length protein coding sequence of clone yd73 — 1 deposited under accession number ATCC 98872; or the nucleotide sequence of a mature protein coding sequence of clone yd73 — 1 deposited under accession number ATCC 98872. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd73 — 1 deposited under accession number ATCC 98872. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:92 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:92, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:92 having biological activity, the fragment comprising the amino acid sequence from amino acid 94 to amino acid 103 of SEQ ID NO:92. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:91. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:91, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:91; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd73 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:91, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:91; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd73 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:91, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:91 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:91, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:91. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:91 from nucleotide 7 to nucleotide 603, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:91 from nucleotide 7 to nucleotide 603, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:91 from nucleotide 7 to nucleotide 603. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:91 from nucleotide 244 to nucleotide 603, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:91 from nucleotide 244 to nucleotide 603, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:91 from nucleotide 244 to nucleotide 603. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:92; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:92, the fragment comprising eight contiguous amino acids of SEQ ID NO:92; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd73 — 1 deposited under accession number ATCC 98872; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:92. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:92 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:92, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:92 having biological activity, the fragment comprising the amino acid sequence from amino acid 94 to amino acid 103 of SEQ ID NO:92. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:93; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:93 from nucleotide 367 to nucleotide 747; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:93 from nucleotide 667 to nucleotide 747; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ye43 — 1 deposited under accession number ATCC 98872; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ye43 — 1 deposited under accession number ATCC 98872; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ye43 — 1 deposited under accession number ATCC 98872; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ye43 — 1 deposited under accession number ATCC 98872; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:94; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:94 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:94; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:93. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:93 from nucleotide 367 to nucleotide 747; the nucleotide sequence of SEQ ID NO:93 from nucleotide 667 to nucleotide 747; the nucleotide sequence of the full-length protein coding sequence of clone ye43 — 1 deposited under accession number ATCC 98872; or the nucleotide sequence of a mature protein coding sequence of clone ye43 — 1 deposited under accession number ATCC 98872. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ye43 — 1 deposited under accession number ATCC 98872. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:94 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:94, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:94 having biological activity, the fragment comprising the amino acid sequence from amino acid 58 to amino acid 67 of SEQ ID NO:94. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:93. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:93, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:93; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ye43 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:93, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:93; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ye43 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:93, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:93 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:93, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:93. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:93 from nucleotide 367 to nucleotide 747, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:93 from nucleotide 367 to nucleotide 747, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:93 from nucleotide 367 to nucleotide 747. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:93 from nucleotide 667 to nucleotide 747, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:93 from nucleotide 667 to nucleotide 747, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:93 from nucleotide 667 to nucleotide 747. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:94; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:94, the fragment comprising eight contiguous amino acids of SEQ ID NO:94; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ye43 — 1 deposited under accession number ATCC 98872; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:94. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:94 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:94, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:94 having biological activity, the fragment comprising the amino acid sequence from amino acid 58 to amino acid 67 of SEQ ID NO:94. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:95; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:95 from nucleotide 632 to nucleotide 1492; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:95 from nucleotide 1460 to nucleotide 1492; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yh71 — 1 deposited under accession number ATCC 98872; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yh71 — 1 deposited under accession number ATCC 98872; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yh71 — 1 deposited under accession number ATCC 98872; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yh71 — 1 deposited under accession number ATCC 98872; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:96; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:96 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:96; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:95. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:95 from nucleotide 632 to nucleotide 1492; the nucleotide sequence of SEQ ID NO:95 from nucleotide 1460 to nucleotide 1492; the nucleotide sequence of the full-length protein coding sequence of clone yh71 — 1 deposited under accession number ATCC 98872; or the nucleotide sequence of a mature protein coding sequence of clone yh71 — 1 deposited under accession number ATCC 98872. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yh71 — 1 deposited under accession number ATCC 98872. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:96 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:96, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:96 having biological activity, the fragment comprising the amino acid sequence from amino acid 138 to amino acid 147 of SEQ ID NO:96. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:95. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:95, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:95; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yh71 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:95, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:95; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yh71 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:95, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:95 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:95, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:95. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:95 from nucleotide 632 to nucleotide 1492, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:95 from nucleotide 632 to nucleotide 1492, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:95 from nucleotide 632 to nucleotide 1492. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:95 from nucleotide 1460 to nucleotide 1492, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:95 from nucleotide 1460 to nucleotide 1492, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:95 from nucleotide 1460 to nucleotide 1492. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:96; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:96, the fragment comprising eight contiguous amino acids of SEQ ID NO:96; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yh71 — 1 deposited under accession number ATCC 98872; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:96. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:96 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:96, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:96 having biological activity, the fragment comprising the amino acid sequence from amino acid 138 to amino acid 147 of SEQ ID NO:96. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:97; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:97 from nucleotide 349 to nucleotide 771; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:97 from nucleotide 490 to nucleotide 771; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yh100 — 1 deposited under accession number ATCC 98872; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yh100 — 1 deposited under accession number ATCC 98872; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yh100 — 1 deposited under accession number ATCC 98872; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yh100 — 1 deposited under accession number ATCC 98872; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:98; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:98 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:98; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:97. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:97 from nucleotide 349 to nucleotide 771; the nucleotide sequence of SEQ ID NO:97 from nucleotide 490 to nucleotide 771; the nucleotide sequence of the full-length protein coding sequence of clone yh100 — 1 deposited under accession number ATCC 98872; or the nucleotide sequence of a mature protein coding sequence of clone yh100 — 1 deposited under accession number ATCC 98872. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yh100 — 1 deposited under accession number ATCC 98872. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:98 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:98, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:98 having biological activity, the fragment comprising the amino acid sequence from amino acid 65 to amino acid 74 of SEQ ID NO:98. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:97. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:97, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:97; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yh100 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:97, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:97; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yh100 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:97, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:97 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:97, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:97. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:97 from nucleotide 349 to nucleotide 771, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:97 from nucleotide 349 to nucleotide 771, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:97 from nucleotide 349 to nucleotide 771. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:97 from nucleotide 490 to nucleotide 771, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:97 from nucleotide 490 to nucleotide 771, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:97 from nucleotide 490 to nucleotide 771. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:98; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:98, the fragment comprising eight contiguous amino acids of SEQ ID NO:98; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yh100 — 1 deposited under accession number ATCC 98872; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:98. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:98 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:98, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:98 having biological activity, the fragment comprising the amino acid sequence from amino acid 65 to amino acid 74 of SEQ ID NO:98. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:99; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:99 from nucleotide 165 to nucleotide 416; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:99 from nucleotide 261 to nucleotide 416; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yi3 — 1 deposited under accession number ATCC 98872; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yi3 — 1 deposited under accession number ATCC 98872; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yi3 — 1 deposited under accession number ATCC 98872; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yi3 — 1 deposited under accession number ATCC 98872; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:100; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:100 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:100; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:99. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:99 from nucleotide 165 to nucleotide 416; the nucleotide sequence of SEQ ID NO:99 from nucleotide 261 to nucleotide 416; the nucleotide sequence of the full-length protein coding sequence of clone yi3 — 1 deposited under accession number ATCC 98872; or the nucleotide sequence of a mature protein coding sequence of clone yi3 — 1 deposited under accession number ATCC 98872. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yi3 — 1 deposited under accession number ATCC 98872. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:100 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:100, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:100 having biological activity, the fragment comprising the amino acid sequence from amino acid 37 to amino acid 46 of SEQ ID NO:100. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:99. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:99, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:99; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yi3 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:99, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:99; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yi3 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:99, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:99 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:99, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:99. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:99 from nucleotide 165 to nucleotide 416, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:99 from nucleotide 165 to nucleotide 416, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:99 from nucleotide 165 to nucleotide 416. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:99 from nucleotide 261 to nucleotide 416, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:99 from nucleotide 261 to nucleotide 416, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:99 from nucleotide 261 to nucleotide 416. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:100; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:100, the fragment comprising eight contiguous amino acids of SEQ ID NO:100; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yi3 — 1 deposited under accession number ATCC 98872; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:100. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:100 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:100, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:100 having biological activity, the fragment comprising the amino acid sequence from amino acid 37 to amino acid 46 of SEQ ID NO:100. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:101; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:101 from nucleotide 141 to nucleotide 995; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:101 from nucleotide 213 to nucleotide 995; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yj23 — 1 deposited under accession number ATCC 98872; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yj23 — 1 deposited under accession number ATCC 98872; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yj23 — 1 deposited under accession number ATCC 98872; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yj23 — 1 deposited under accession number ATCC 98872; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:102; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:102 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:102; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:101. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:101 from nucleotide 141 to nucleotide 995; the nucleotide sequence of SEQ ID NO:101 from nucleotide 213 to nucleotide 995; the nucleotide sequence of the full-length protein coding sequence of clone yj23 — 1 deposited under accession number ATCC 98872; or the nucleotide sequence of a mature protein coding sequence of clone yj23 — 1 deposited under accession number ATCC 98872. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yj23 — 1 deposited under accession number ATCC 98872. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:102 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:102, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:102 having biological activity, the fragment comprising the amino acid sequence from amino acid 137 to amino acid 146 of SEQ ID NO:102. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:101. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:101, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:101; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yj23 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:101, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:101; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yj23 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:101, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:101 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:101, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:101. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:101 from nucleotide 141 to nucleotide 995, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:101 from nucleotide 141 to nucleotide 995, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:101 from nucleotide 141 to nucleotide 995. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:101 from nucleotide 213 to nucleotide 995, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:101 from nucleotide 213 to nucleotide 995, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:101 from nucleotide 213 to nucleotide 995. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:102; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:102, the fragment comprising eight contiguous amino acids of SEQ ID NO:102; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yj23 — 1 deposited under accession number ATCC 98872; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:102. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:102 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:102, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:102 having biological activity, the fragment comprising the amino acid sequence from amino acid 137 to amino acid 146 of SEQ ID NO:102. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:103; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:103 from nucleotide 13 to nucleotide 747; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:103 from nucleotide 67 to nucleotide 747; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yl9 — 1 deposited under accession number ATCC 98872; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yl9 — 1 deposited under accession number ATCC 98872; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yl9 — 1 deposited under accession number ATCC 98872; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yl9 — 1 deposited under accession number ATCC 98872; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:104; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:104 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:104; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:103. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:103 from nucleotide 13 to nucleotide 747; the nucleotide sequence of SEQ ID NO:103 from nucleotide 67 to nucleotide 747; the nucleotide sequence of the full-length protein coding sequence of clone yl9 — 1 deposited under accession number ATCC 98872; or the nucleotide sequence of a mature protein coding sequence of clone yl9 — 1 deposited under accession number ATCC 98872. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yl9 — 1 deposited under accession number ATCC 98872. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:104 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:104, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:104 having biological activity, the fragment comprising the amino acid sequence from amino acid 117 to amino acid 126 of SEQ ID NO:104. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:103. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:103, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:103; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yl9 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:103, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:103; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yl9 — 1 deposited under accession number ATCC 98872; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:103, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:103 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:103, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:103. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:103 from nucleotide 13 to nucleotide 747, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:103 from nucleotide 13 to nucleotide 747, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:103 from nucleotide 13 to nucleotide 747. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:103 from nucleotide 67 to nucleotide 747, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:103 from nucleotide 67 to nucleotide 747, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:103 from nucleotide 67 to nucleotide 747. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:104; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:104, the fragment comprising eight contiguous amino acids of SEQ ID NO:104; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yl9 — 1 deposited under accession number ATCC 98872; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:104. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:104 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:104, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:104 having biological activity, the fragment comprising the amino acid sequence from amino acid 117 to amino acid 126 of SEQ ID NO:104. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:105; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:105 from nucleotide 375 to nucleotide 728; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ya66 — 1 deposited under accession number ATCC 98887; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ya66 — 1 deposited under accession number ATCC 98887; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ya66 — 1 deposited under accession number ATCC 98887; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ya66 — 1 deposited under accession number ATCC 98887; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:106; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:106 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:106; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:105. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:105 from nucleotide 375 to nucleotide 728; the nucleotide sequence of the full-length protein coding sequence of clone ya66 — 1 deposited under accession number ATCC 98887; or the nucleotide sequence of a mature protein coding sequence of clone ya66 — 1 deposited under accession number ATCC 98887. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ya66 — 1 deposited under accession number ATCC 98887. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:106 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:106, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:106 having biological activity, the fragment comprising the amino acid sequence from amino acid 54 to amino acid 63 of SEQ ID NO:106. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:105. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:105, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:105; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ya66 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:105, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:105; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ya66 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:105, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:105 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:105, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:105. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:105 from nucleotide 375 to nucleotide 728, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:105 from nucleotide 375 to nucleotide 728, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:105 from nucleotide 375 to nucleotide 728. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:106; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:106, the fragment comprising eight contiguous amino acids of SEQ ID NO:106; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ya66 — 1 deposited under accession number ATCC 98887; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:106. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:106 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:106, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:106 having biological activity, the fragment comprising the amino acid sequence from amino acid 54 to amino acid 63 of SEQ ID NO:106. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:107; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:107 from nucleotide 131 to nucleotide 457; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb187 — 1 deposited under accession number ATCC 98887; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb187 — 1 deposited under accession number ATCC 98887; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb187 — 1 deposited under accession number ATCC 98887; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb187 — 1 deposited under accession number ATCC 98887; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:108; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:108 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:108; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:107. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:107 from nucleotide 131 to nucleotide 457; the nucleotide sequence of the full-length protein coding sequence of clone yb187 — 1 deposited under accession number ATCC 98887; or the nucleotide sequence of a mature protein coding sequence of clone yb187 — 1 deposited under accession number ATCC 98887. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb187 — 1 deposited under accession number ATCC 98887. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:108 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:108, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:108 having biological activity, the fragment comprising the amino acid sequence from amino acid 49 to amino acid 58 of SEQ ID NO:108. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:107. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:107, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:107; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb187 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:107, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:107; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb187 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:107, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:107 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:107, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:107. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:107 from nucleotide 131 to nucleotide 457, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:107 from nucleotide 131 to nucleotide 457, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:107 from nucleotide 131 to nucleotide 457. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:108; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:108, the fragment comprising eight contiguous amino acids of SEQ ID NO:108; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb187 — 1 deposited under accession number ATCC 98887; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:108. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:108 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:108, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:108 having biological activity, the fragment comprising the amino acid sequence from amino acid 49 to amino acid 58 of SEQ ID NO:108. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:109; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:109 from nucleotide 458 to nucleotide 676; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:109 from nucleotide 503 to nucleotide 676; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb219 — 1 deposited under accession number ATCC 98887; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb219 — 1 deposited under accession number ATCC 98887; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb219 — 1 deposited under accession number ATCC 98887; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb219 — 1 deposited under accession number ATCC 98887; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:110; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:110 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:110; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:109. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:109 from nucleotide 458 to nucleotide 676; the nucleotide sequence of SEQ ID NO:109 from nucleotide 503 to nucleotide 676; the nucleotide sequence of the full-length protein coding sequence of clone yb219 — 1 deposited under accession number ATCC 98887; or the nucleotide sequence of a mature protein coding sequence of clone yb219 — 1 deposited under accession number ATCC 98887. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb219 — 1 deposited under accession number ATCC 98887. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:110 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:110, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:110 having biological activity, the fragment comprising the amino acid sequence from amino acid 31 to amino acid 40 of SEQ ID NO:110. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:109. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:109, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:109; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb219 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:109, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:109; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb219 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:109, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:109 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:109, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:109. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:109 from nucleotide 458 to nucleotide 676, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:109 from nucleotide 458 to nucleotide 676, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:109 from nucleotide 458 to nucleotide 676. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:109 from nucleotide 503 to nucleotide 676, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:109 from nucleotide 503 to nucleotide 676, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:109 from nucleotide 503 to nucleotide 676. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:110; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:110, the fragment comprising eight contiguous amino acids of SEQ ID NO:110; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb219 — 1 deposited under accession number ATCC 98887; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:110. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:110 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:110, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:110 having biological activity, the fragment comprising the amino acid sequence from amino acid 31 to amino acid 40 of SEQ ID NO:110. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:111; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:111 from nucleotide 238 to nucleotide 396; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:111 from nucleotide 277 to nucleotide 396; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb228 — 1 deposited under accession number ATCC 98887; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb228 — 1 deposited under accession number ATCC 98887; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb228 — 1 deposited under accession number ATCC 98887; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb228 — 1 deposited under accession number ATCC 98887; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:112; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:112 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:112; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:111. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:111 from nucleotide 238 to nucleotide 396; the nucleotide sequence of SEQ ID NO:111 from nucleotide 277 to nucleotide 396; the nucleotide sequence of the full-length protein coding sequence of clone yb228 — 1 deposited under accession number ATCC 98887; or the nucleotide sequence of a mature protein coding sequence of clone yb228 — 1 deposited under accession number ATCC 98887. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb228 — 1 deposited under accession number ATCC 98887. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:112 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:112, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:112 having biological activity, the fragment comprising the amino acid sequence from amino acid 21 to amino acid 30 of SEQ ID NO:112. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:111. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:111, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:111; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb228 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:111, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:111; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb228 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:111, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:111 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:111, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:111. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:111 from nucleotide 238 to nucleotide 396, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:111 from nucleotide 238 to nucleotide 396, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:111 from nucleotide 238 to nucleotide 396. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:111 from nucleotide 277 to nucleotide 396, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:111 from nucleotide 277 to nucleotide 396, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:111 from nucleotide 277 to nucleotide 396. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:112; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:112, the fragment comprising eight contiguous amino acids of SEQ ID NO:112; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb228 — 1 deposited under accession number ATCC 98887; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:112. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:112 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:112, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:112 having biological activity, the fragment comprising the amino acid sequence from amino acid 21 to amino acid 30 of SEQ ID NO:112. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:113; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:113 from nucleotide 6 to nucleotide 722; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:113 from nucleotide 375 to nucleotide 722; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yc27 — 1 deposited under accession number ATCC 98887; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yc27 — 1 deposited under accession number ATCC 98887; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yc27 — 1 deposited under accession number ATCC 98887; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yc27 — 1 deposited under accession number ATCC 98887; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:114; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:114 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:114; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:113. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:113 from nucleotide 6 to nucleotide 722; the nucleotide sequence of SEQ ID NO:113 from nucleotide 375 to nucleotide 722; the nucleotide sequence of the full-length protein coding sequence of clone yc27 — 1 deposited under accession number ATCC 98887; or the nucleotide sequence of a mature protein coding sequence of clone yc27 — 1 deposited under accession number ATCC 98887. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yc27 — 1 deposited under accession number ATCC 98887. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:114 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:114, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:114 having biological activity, the fragment comprising the amino acid sequence from amino acid 114 to amino acid 123 of SEQ ID NO:114. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:113. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:113, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:113; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yc27 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:113, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:113; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yc27 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:113, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:113 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:113, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:113. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:113 from nucleotide 6 to nucleotide. 722, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:113 from nucleotide 6 to nucleotide 722, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:113 from nucleotide 6 to nucleotide 722. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:113 from nucleotide 375 to nucleotide 722, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:113 from nucleotide 375 to nucleotide 722, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:113 from nucleotide 375 to nucleotide 722. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:114; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:114, the fragment comprising eight contiguous amino acids of SEQ ID NO:114; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yc27 — 1 deposited under accession number ATCC 98887; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:114. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:114 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:114, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:114 having biological activity, the fragment comprising the amino acid sequence from amino acid 114 to amino acid 123 of SEQ ID NO:114. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:115; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:115 from nucleotide 382 to nucleotide 681; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yc49 — 1 deposited under accession number ATCC 98887; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yc49 — 1 deposited under accession number ATCC 98887; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yc49 — 1 deposited under accession number ATCC 98887; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yc49 — 1 deposited under accession number ATCC 98887; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:116; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:116 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:116; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:115. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:115 from nucleotide 382 to nucleotide 681; the nucleotide sequence of the full-length protein coding sequence of clone yc49 — 1 deposited under accession number ATCC 98887; or the nucleotide sequence of a mature protein coding sequence of clone yc49 — 1 deposited under accession number ATCC 98887. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yc49 — 1 deposited under accession number ATCC 98887. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:116 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:116, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:116 having biological activity, the fragment comprising the amino acid sequence from amino acid 45 to amino acid 54 of SEQ ID NO:116. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:115. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:115, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:115; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yc49 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO: 15, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:115; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yc49 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:115, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:115 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:115, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:115. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:115 from nucleotide 382 to nucleotide 681, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:115 from nucleotide 382 to nucleotide 681, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:115 from nucleotide 382 to nucleotide 681. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:116; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:116, the fragment comprising eight contiguous amino acids of SEQ ID NO:116; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yc49 — 1 deposited under accession number ATCC 98887; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:116. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:116 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:116, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:116 having biological activity, the fragment comprising the amino acid sequence from amino acid 45 to amino acid 54 of SEQ ID NO:116. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:117; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:117 from nucleotide 71 to nucleotide 364; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd40 — 1 deposited under accession number ATCC 98887; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd40 — 1 deposited under accession number ATCC 98887; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd40 — 1 deposited under accession number ATCC 98887; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd40 — 1 deposited under accession number ATCC 98887; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:118; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:118 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:118; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:117. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:117 from nucleotide 71 to nucleotide 364; the nucleotide sequence of the full-length protein coding sequence of clone yd40 — 1 deposited under accession number ATCC 98887; or the nucleotide sequence of a mature protein coding sequence of clone yd40 — 1 deposited under accession number ATCC 98887. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd40 — 1 deposited under accession number ATCC 98887. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:118 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:118, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:118 having biological activity, the fragment comprising the amino acid sequence from amino acid 44 to amino acid 53 of SEQ ID NO:118. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:117. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:117, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:117; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd40 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:117, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:117; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd40 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:117, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:117 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:117, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:117. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:117 from nucleotide 71 to nucleotide 364, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:117 from nucleotide 71 to nucleotide 364, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:117 from nucleotide 71 to nucleotide 364. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:118; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:118, the fragment comprising eight contiguous amino acids of SEQ ID NO:118; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd40 — 1 deposited under accession number ATCC 98887; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:118. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:118 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:118, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:118 having biological activity, the fragment comprising the amino acid sequence from amino acid 44 to amino acid 53 of SEQ ID NO:118. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:119; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:119 from nucleotide 75 to nucleotide 725; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd64 — 1 deposited under accession number ATCC 98887; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd64 — 1 deposited under accession number ATCC 98887; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd64 — 1 deposited under accession number ATCC 98887; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd64 — 1 deposited under accession number ATCC 98887; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:120; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:120 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:120; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:119. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:119 from nucleotide 75 to nucleotide 725; the nucleotide sequence of the full-length protein coding sequence of clone yd64 — 1 deposited under accession number ATCC 98887; or the nucleotide sequence of a mature protein coding sequence of clone yd64 — 1 deposited under accession number ATCC 98887. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd64 — 1 deposited under accession number ATCC 98887. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:120 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:120, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:120 having biological activity, the fragment comprising the amino acid sequence from amino acid 103 to amino acid 112 of SEQ ID NO:120. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:119. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:119, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:119; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd64 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:119, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:119; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd64 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:119, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:119 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:119, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:119. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:119 from nucleotide 75 to nucleotide 725, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:119 from nucleotide 75 to nucleotide 725, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:119 from nucleotide 75 to nucleotide 725. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:120; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:120, the fragment comprising eight contiguous amino acids of SEQ ID NO:120; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd64 — 1 deposited under accession number ATCC 98887; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:120. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:120 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:120, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:120 having biological activity, the fragment comprising the amino acid sequence from amino acid 103 to amino acid 112 of SEQ ID NO:120. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:121; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:121 from nucleotide 256 to nucleotide 780; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:121 from nucleotide 412 to nucleotide 780; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ye47 — 1 deposited under accession number ATCC 98887; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ye47 — 1 deposited under accession number ATCC 98887; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ye47 — 1 deposited under accession number ATCC 98887; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ye47 — 1 deposited under accession number ATCC 98887; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:122; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:122 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:122; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:121. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:121 from nucleotide 256 to nucleotide 780; the nucleotide sequence of SEQ ID NO:121 from nucleotide 412 to nucleotide 780; the nucleotide sequence of the full-length protein coding sequence of clone ye47 — 1 deposited under accession number ATCC 98887; or the nucleotide sequence of a mature protein coding sequence of clone ye47 — 1 deposited under accession number ATCC 98887. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ye47 — 1 deposited under accession number ATCC 98887. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:122 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:122, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:122 having biological activity, the fragment comprising the amino acid sequence from amino acid 82 to amino acid 91 of SEQ ID NO:122. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:121. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:121, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:121; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ye47 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:121, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:121; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ye47 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:121, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:121 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:121, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:121. Also preferably the ;polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:12 from nucleotide 256 to nucleotide 780, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:121 from nucleotide 256 to nucleotide 780, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:121 from nucleotide 256 to nucleotide 780. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:121 from nucleotide 412 to nucleotide 780, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:121 from nucleotide 412 to nucleotide 780, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:121 from nucleotide 412 to nucleotide 780. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:122; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:122, the fragment comprising eight contiguous amino acids of SEQ ID NO:122; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ye47 — 1 deposited under accession number ATCC 98887; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:122. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:122 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:122, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:22 having biological activity, the fragment comprising the amino acid sequence from amino acid 82 to amino acid 9 of SEQ ID NO:122. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:123; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:123 from nucleotide 127 to nucleotide 405; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:123 from nucleotide 268 to nucleotide 405; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yh50 — 1 deposited under accession number ATCC 98887; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yh50 — 1 deposited under accession number ATCC 98887; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yh50 — 1 deposited under accession number ATCC 98887; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yh50 — 1 deposited under accession number ATCC 98887; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:124; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:124 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:124; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:123. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:123 from nucleotide 127 to nucleotide 405; the nucleotide sequence of SEQ ID NO:123 from nucleotide 268 to nucleotide 405; the nucleotide sequence of the full-length protein coding sequence of clone yh50 — 1 deposited under accession number ATCC 98887; or the nucleotide sequence of a mature protein coding sequence of clone yh50 — 1 deposited under accession number ATCC 98887. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yh50 — 1 deposited under accession number ATCC 98887. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:124 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:124, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:124 having biological activity, the fragment comprising the amino acid sequence from amino acid 41 to amino acid 50 of SEQ ID NO:124. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:123. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:123, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:123; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yh50 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:123, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:123; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yh50 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:123, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:123 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:123, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:123. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:123 from nucleotide 127 to nucleotide 405, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:123 from nucleotide 127 to nucleotide 405, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:123 from nucleotide 127 to nucleotide 405. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:123 from nucleotide 268 to nucleotide 405, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:123 from nucleotide 268 to nucleotide 405, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:123 from nucleotide 268 to nucleotide 405. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:124; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:124, the fragment comprising eight contiguous amino acids of SEQ ID NO:124; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yh50 — 1 deposited under accession number ATCC 98887; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:124. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:124 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:124, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:124 having biological activity, the fragment comprising the amino acid sequence from amino acid 41 to amino acid 50 of SEQ ID NO:124. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:125; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:125 from nucleotide 1175 to nucleotide 1480; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yh53 — 1 deposited under accession number ATCC 98887; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yh53 — 1 deposited under accession number ATCC 98887; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yh53 — 1 deposited under accession number ATCC 98887; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yh53 — 1 deposited under accession number ATCC 98887; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:126; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:126 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:126; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:125. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:125 from nucleotide 1175 to nucleotide 1480; the nucleotide sequence of the full-length protein coding sequence of clone yh53 — 1 deposited under accession number ATCC 98887; or the nucleotide sequence of a mature protein coding sequence of clone yh53 — 1 deposited under accession number ATCC 98887. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yh53 — 1 deposited under accession number ATCC 98887. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:126 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:126, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:126 having biological activity, the fragment comprising the amino acid sequence from amino acid 46 to amino acid 55 of SEQ ID NO:126. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:125. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:125, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:125; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yh53 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:125, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:125; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yh53 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:125, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:125 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:125, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:125. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:125 from nucleotide 1175 to nucleotide 1480, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:125 from nucleotide 1175 to nucleotide 1480, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:125 from nucleotide 1175 to nucleotide 1480. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:126; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:126, the fragment comprising eight contiguous amino acids of SEQ ID NO:126; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yh53 — 1 deposited under accession number ATCC 98887; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:126. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:126 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:126, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:126 having biological activity, the fragment comprising the amino acid sequence from amino acid 46 to amino acid 55 of SEQ ID NO:126. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:127; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:127 from nucleotide 65 to nucleotide 319; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:127 from nucleotide 173 to nucleotide 319; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yh98 — 1 deposited under accession number ATCC 98887; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yh98 — 1 deposited under accession number ATCC 98887; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yh98 — 1 deposited under accession number ATCC 98887; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yh98 — 1 deposited under accession number ATCC 98887; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:128; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:128 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:128; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:127. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:127 from nucleotide 65 to nucleotide 319; the nucleotide sequence of SEQ ID NO:127 from nucleotide 173 to nucleotide 319; the nucleotide sequence of the full-length protein coding sequence of clone yh98 — 1 deposited under accession number ATCC 98887; or the nucleotide sequence of a mature protein coding sequence of clone yh98 — 1 deposited under accession number ATCC 98887. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yh98 — 1 deposited under accession number ATCC 98887. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:128 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:128, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:128 having biological activity, the fragment comprising the amino acid sequence from amino acid 37 to amino acid 46 of SEQ ID NO:128. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:127. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:127, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:127; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yh98 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:127, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:127; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yh98 — 1 deposited under accession number ATCC 98887; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:127, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:127 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:127, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:127. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:127 from nucleotide 65 to nucleotide 319, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:127 from nucleotide 65 to nucleotide 319, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:127 from nucleotide 65 to nucleotide 319. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:127 from nucleotide 173 to nucleotide 319, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:127 from nucleotide 173 to nucleotide 319, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:127 from nucleotide 173 to nucleotide 319. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:128; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:128, the fragment comprising eight contiguous amino acids of SEQ ID NO:128; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yh98 — 1 deposited under accession number ATCC 98887; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:128. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:128 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:128, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:128 having biological activity, the fragment comprising the amino acid sequence from amino acid 37 to amino acid 46 of SEQ ID NO:128. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:129; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:129 from nucleotide 122 to nucleotide 469; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:129 from nucleotide 263 to nucleotide 469; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ya69 — 1 deposited under accession number ATCC 98915; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ya69 — 1 deposited under accession number ATCC 98915; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ya69 — 1 deposited under accession number ATCC 98915; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ya69 — 1 deposited under accession number ATCC 98915; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:130; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:130 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:130; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:129. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:129 from nucleotide 122 to nucleotide 469; the nucleotide sequence of SEQ ID NO:129 from nucleotide 263 to nucleotide 469; the nucleotide sequence of the full-length protein coding sequence of clone ya69 — 1 deposited under accession number ATCC 98915; or the nucleotide sequence of a mature protein coding sequence of clone ya69 — 1 deposited under accession number ATCC 98915. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ya69 — 1 deposited under accession number ATCC 98915. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:130 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:130, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:130 having biological activity, the fragment comprising the amino acid sequence from amino acid 53 to amino acid 62 of SEQ ID NO:130. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:129. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:129, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:129; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ya69 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:129, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:129; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ya69 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:129, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:129 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:129, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:129. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:129 from nucleotide 122 to nucleotide 469, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:129 from nucleotide 122 to nucleotide 469, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:129 from nucleotide 122 to nucleotide 469. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:129 from nucleotide 263 to nucleotide 469, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:129 from nucleotide 263 to nucleotide 469, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:129 from nucleotide 263 to nucleotide 469. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:130; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:130, the fragment comprising eight contiguous amino acids of SEQ ID NO:130; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ya69 — 1 deposited under accession number ATCC 98915; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:130. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:130 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:130, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:130 having biological activity, the fragment comprising the amino acid sequence from amino acid 53 to amino acid 62 of SEQ ID NO:130. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:131; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:131 from nucleotide 36 to nucleotide 554; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:131 from nucleotide 183 to nucleotide 554; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd107 — 1 deposited under accession number ATCC 98915; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd107 — 1 deposited under accession number ATCC 98915; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd107 — 1 deposited under accession number ATCC 98915; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd107 — 1 deposited under accession number ATCC 98915; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:132; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:132 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:132; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:131. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:131 from nucleotide 36 to nucleotide 554; the nucleotide sequence of SEQ ID NO:131 from nucleotide 183 to nucleotide 554; the nucleotide sequence of the full-length protein coding sequence of clone yd107 — 1 deposited under accession number ATCC 98915; or the nucleotide sequence of a mature protein coding sequence of clone yd107 — 1 deposited under accession number ATCC 98915. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd107 — 1 deposited under accession number ATCC 98915. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:132 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:132, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:132 having biological activity, the fragment comprising the amino acid sequence from amino acid 81 to amino acid 90 of SEQ ID NO:132. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:131. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:131, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:131; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd107 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:131, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:131; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd107 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:131, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:131 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:131, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:131. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:131 from nucleotide 36 to nucleotide 554, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:131 from nucleotide 36 to nucleotide 554, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:131 from nucleotide 36 to nucleotide 554. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:131 from nucleotide 183 to nucleotide 554, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:131 from nucleotide 183 to nucleotide 554, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:131 from nucleotide 183 to nucleotide 554. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:132; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:132, the fragment comprising eight contiguous amino acids of SEQ ID NO:132; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd107 — 1 deposited under accession number ATCC 98915; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:132. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:132 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:132, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:132 having biological activity, the fragment comprising the amino acid sequence from amino acid 81 to amino acid 90 of SEQ ID NO:132. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:133; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:133 from nucleotide 8 to nucleotide 493; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:133 from nucleotide 53 to nucleotide 493; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd145 — 1 deposited under accession number ATCC 98915; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd145 — 1 deposited under accession number ATCC 98915; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd145 — 1 deposited under accession number ATCC 98915; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd145 — 1 deposited under accession number ATCC 98915; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:134; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:134 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:134; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:133. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:133 from nucleotide 8 to nucleotide 493; the nucleotide sequence of SEQ ID NO:133 from nucleotide 53 to nucleotide 493; the nucleotide sequence of the full-length protein coding sequence of clone yd145 — 1 deposited under accession number ATCC 98915; or the nucleotide sequence of a mature protein coding sequence of clone yd145 — 1 deposited under accession number ATCC 98915. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd145 — 1 deposited under accession number ATCC 98915. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:134 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:134, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:134 having biological activity, the fragment comprising the amino acid sequence from amino acid 76 to amino acid 85 of SEQ ID NO:134. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:133. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:133, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:133; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd145 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:133, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:133; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd145 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:133, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:133 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:133, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:133. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:133 from nucleotide 8 to nucleotide 493, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:133 from nucleotide 8 to nucleotide 493, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:133 from nucleotide 8 to nucleotide 493. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:133 from nucleotide 53 to nucleotide 493, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:133 from nucleotide 53 to nucleotide 493, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:133 from nucleotide 53 to nucleotide 493. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:134; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:134, the fragment comprising eight contiguous amino acids of SEQ ID NO:134; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd145 — 1 deposited under accession number ATCC 98915; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:134. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:134 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:134, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:134 having biological activity, the fragment comprising the amino acid sequence from amino acid 76 to amino acid 85 of SEQ ID NO:134. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:135; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:135 from nucleotide 21 to nucleotide 308; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yh24 — 1 deposited under accession number ATCC 98915; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yh24 — 1 deposited under accession number ATCC 98915; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yh24 — 1 deposited under accession number ATCC 98915; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yh24 — 1 deposited under accession number ATCC 98915; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:136; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:136 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:136; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:135. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:135 from nucleotide 21 to nucleotide 308; the nucleotide sequence of the full-length protein coding sequence of clone yh24 — 1 deposited under accession number ATCC 98915; or the nucleotide sequence of a mature protein coding sequence of clone yh24 — 1 deposited under accession number ATCC 98915. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yh24 — 1 deposited under accession number ATCC 98915. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:136 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:136, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:136 having biological activity, the fragment comprising the amino acid sequence from amino acid 43 to amino acid 52 of SEQ ID NO:136. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:135. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:135, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:135; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yh24 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:135, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:135; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yh24 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:135, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:135 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:135, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:135. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:135 from nucleotide 21 to nucleotide 308, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:135 from nucleotide 21 to nucleotide 308, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:135 from nucleotide 21 to nucleotide 308. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:136; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:136, the fragment comprising eight contiguous amino acids of SEQ ID NO:136; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yh24 — 1 deposited under accession number ATCC 98915; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:136. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:136 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:136, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:136 having biological activity, the fragment comprising the amino acid sequence from amino acid 43 to amino acid 52 of SEQ ID NO:136. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID. NO:137; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:137 from nucleotide 214 to nucleotide 735; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:137 from nucleotide 634 to nucleotide 735; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yi11 — 1 deposited under accession number ATCC 98915; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yi11 — 1 deposited under accession number ATCC 98915; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yi11 — 1 deposited under accession number ATCC 98915; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yi11 — 1 deposited under accession number ATCC 98915; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:138; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:138 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:138; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:137. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:137 from nucleotide 214 to nucleotide 735; the nucleotide sequence of SEQ ID NO:137 from nucleotide 634 to nucleotide 735; the nucleotide sequence of the full-length protein coding sequence of clone yi11 — 1 deposited under accession number ATCC 98915; or the nucleotide sequence of a mature protein coding sequence of clone yi11 — 1 deposited under accession number ATCC 98915. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yi11 — 1 deposited under accession number ATCC 98915. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:138 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:138, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:138 having biological activity, the fragment comprising the amino acid sequence from amino acid 82 to amino acid 91 of SEQ ID NO:138. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:137. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:137, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:137; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yi11 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:137, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:137; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yi11 — 1 deposited under accession number ATCC 98915; 
     (j) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:137, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:137 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:137, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:137. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:137 from nucleotide 214 to nucleotide 735, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:137 from nucleotide 214 to nucleotide 735, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:137 from nucleotide 214 to nucleotide 735. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:137 from nucleotide 634 to nucleotide 735, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:137 from nucleotide 634 to nucleotide 735, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:137 from nucleotide 634 to nucleotide 735. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:138; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:138, the fragment comprising eight contiguous amino acids of SEQ ID NO:138; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yi11 — 1 deposited under accession number ATCC 98915; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:138. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:138 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:138, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:138 having biological activity, the fragment comprising the amino acid sequence from amino acid 82 to amino acid 91 of SEQ ID NO:138. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:139; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:139 from nucleotide 668 to nucleotide 937; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:139 from nucleotide 848 to nucleotide 937; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yi18 — 1 deposited under accession number ATCC 98915; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yi18 — 1 deposited under accession number ATCC 98915; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yi18 — 1 deposited under accession number ATCC 98915; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yi18 — 1 deposited under accession number ATCC 98915; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:140; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:140 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:140; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:139. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:139 from nucleotide 668 to nucleotide 937; the nucleotide sequence of SEQ ID NO:139 from nucleotide 848 to nucleotide 937; the nucleotide sequence of the full-length protein coding sequence of clone yi18 — 1 deposited under accession number ATCC 98915; or the nucleotide sequence of a mature protein coding sequence of clone yi18 — 1 deposited under accession number ATCC 98915. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yi18 — 1 deposited under accession number ATCC 98915. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:140 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:140, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:140 having biological activity, the fragment comprising the amino acid sequence from amino acid 40 to amino acid 49 of SEQ ID NO:140. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:139. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:139, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:139; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yi18 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:139, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:139; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yi18 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:139, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:139 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:139, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:139. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:139 from nucleotide 668 to nucleotide 937, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:139 from nucleotide 668 to nucleotide 937, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:139 from nucleotide 668 to nucleotide 937. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:139 from nucleotide 848 to nucleotide 937, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:139 from nucleotide 848 to nucleotide 937, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:139 from nucleotide 848 to nucleotide 937. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO: 140; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:140, the fragment comprising eight contiguous amino acids of SEQ ID NO:140; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yi18 — 1 deposited under accession number ATCC 98915; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:140. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:140 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:140, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:140 having biological activity, the fragment comprising the amino acid sequence from amino acid 40 to amino acid 49 of SEQ ID NO:140. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:141; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:141 from nucleotide 171 to nucleotide 407; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:141 from nucleotide 258 to nucleotide 407; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk14 — 1 deposited under accession number ATCC 98915; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk14 — 1 deposited under accession number ATCC 98915; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk14 — 1 deposited under accession number ATCC 98915; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk14 — 1 deposited under accession number ATCC 98915; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:142; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:142 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:142; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:141. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:141 from nucleotide 171 to nucleotide 407; the nucleotide sequence of SEQ ID NO:141 from nucleotide 258 to nucleotide 407; the nucleotide sequence of the full-length protein coding sequence of clone yk14 — 1 deposited under accession number ATCC 98915; or the nucleotide sequence of a mature protein coding sequence of clone yk14 — 1 deposited under accession number ATCC 98915. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk14 — 1 deposited under accession number ATCC 98915. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:142 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:142, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:142 having biological activity, the fragment comprising the amino acid sequence from amino acid 34 to amino acid 43 of SEQ ID NO:142. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:141. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:141, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:141; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk14 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:141, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:141; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk14 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:141, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:141 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:141, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:141. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:141 from nucleotide 171 to nucleotide 407, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:141 from nucleotide 171 to nucleotide 407, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:141 from nucleotide 171 to nucleotide 407. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:141 from nucleotide 258 to nucleotide 407, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:141 from nucleotide 258 to nucleotide 407, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:141 from nucleotide 258 to nucleotide 407. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:142; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:142, the fragment comprising eight contiguous amino acids of SEQ ID NO:142; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk14 — 1 deposited under accession number ATCC 98915; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:142. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:142 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:142, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:142 having biological activity, the fragment comprising the amino acid sequence from amino acid 34 to amino acid 43 of SEQ ID NO:142. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:143; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:143 from nucleotide 164 to nucleotide 457; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk39 — 1 deposited under accession number ATCC 98915; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk39 — 1 deposited under accession number ATCC 98915; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk39 — 1 deposited under accession number ATCC 98915; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk39 — 1 deposited under accession number ATCC 98915; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:144; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:144 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:144; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:143. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:143 from nucleotide 164 to nucleotide 457; the nucleotide sequence of the full-length protein coding sequence of clone yk39 — 1 deposited under accession number ATCC 98915; or the nucleotide sequence of a mature protein coding sequence of clone yk39 — 1 deposited under accession number ATCC 98915. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk39 — 1 deposited under accession number ATCC 98915. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:144 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:144, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:144 having biological activity, the fragment comprising the amino acid sequence from amino acid 44 to amino acid 53 of SEQ ID NO:144. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:143. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:143, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:143; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk39 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:143, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:143; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk39 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:143, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:143 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:143, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:143. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:143 from nucleotide 164 to nucleotide 457, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:143 from nucleotide 164 to nucleotide 457, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:143 from nucleotide 164 to nucleotide 457. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:144; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:144, the fragment comprising eight contiguous amino acids of SEQ ID NO:144; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk39 — 1 deposited under accession number ATCC 98915; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:144. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:144 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:144, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:144 having biological activity, the fragment comprising the amino acid sequence from amino acid 44 to amino acid 53 of SEQ ID NO:144. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:145; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:145 from nucleotide 72 to nucleotide 500; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 145 from nucleotide 255 to nucleotide 500; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk91 — 1 deposited under accession number ATCC 98915; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk91 — 1 deposited under accession number ATCC 98915; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk91 — 1 deposited under accession number ATCC 98915; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk91 — 1 deposited under accession number ATCC 98915; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:146; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:146 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:146; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:145. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:145 from nucleotide 72 to nucleotide 500; the nucleotide sequence of SEQ ID NO:145 from nucleotide 255 to nucleotide 500; the nucleotide sequence of the full-length protein coding sequence of clone yk91 — 1 deposited under accession number ATCC 98915; or the nucleotide sequence of a mature protein coding sequence of clone yk91 — 1 deposited under accession number ATCC 98915. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk91 — 1 deposited under accession number ATCC 98915. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:146 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:146, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:146 having biological activity, the fragment comprising the amino acid sequence from amino acid 66 to amino acid 75 of SEQ ID NO:146. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:145. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:145, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:145; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk91 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:145, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:145; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk91 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:145, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:145 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:145, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:145. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:145 from nucleotide 72 to nucleotide 500, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:145 from nucleotide 72 to nucleotide 500, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:145 from nucleotide 72 to nucleotide 500. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:145 from nucleotide 255 to nucleotide 500, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:145 from nucleotide 255 to nucleotide 500, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:145 from nucleotide 255 to nucleotide 500. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:146; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:146, the fragment comprising eight contiguous amino acids of SEQ ID NO:146; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk91 — 1 deposited under accession number ATCC 98915; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:146. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:146 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:146, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:146 having biological activity, the fragment comprising the amino acid sequence from amino acid 66 to amino acid 75 of SEQ ID NO:146. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:147; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:147 from nucleotide 174 to nucleotide 620; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:147 from nucleotide 240 to nucleotide 620; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk199 — 1 deposited under accession number ATCC 98915; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk199 — 1 deposited under accession number ATCC 98915; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk199 — 1 deposited under accession number ATCC 98915; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk199 — 1 deposited under accession number ATCC 98915; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:148; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:148 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:148; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:147. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:147 from nucleotide 174 to nucleotide 620; the nucleotide sequence of SEQ ID NO:147 from nucleotide 240 to nucleotide 620; the nucleotide sequence of the full-length protein coding sequence of clone yk199 — 1 deposited under accession number ATCC 98915; or the nucleotide sequence of a mature protein coding sequence of clone yk199 — 1 deposited under accession number ATCC 98915. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of done yk199 — 1 deposited under accession number ATCC 98915. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:148 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:148, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:148 having biological activity, the fragment comprising the amino acid sequence from amino acid 69 to amino acid 78 of SEQ ID NO:148. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:147. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:147, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:147; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk199 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:147, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:147; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk199 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:147, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:147 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:147, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:147. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:147 from nucleotide 174 to nucleotide 620, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:147 from nucleotide 174 to nucleotide 620, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:147 from nucleotide 174 to nucleotide 620. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:147 from nucleotide 240 to nucleotide 620, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:147 from nucleotide 240 to nucleotide 620, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:147 from nucleotide 240 to nucleotide 620. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:148; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:148, the fragment comprising eight contiguous amino acids of SEQ ID NO:148; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk199 — 1 deposited under accession number ATCC 98915; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:148. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:148 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:148, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:148 having biological activity, the fragment comprising the amino acid sequence from amino acid 69 to amino acid 78 of SEQ ID NO:148. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:149; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:149 from nucleotide 325 to nucleotide 984; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:149 from nucleotide 973 to nucleotide 984; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yl4 — 1 deposited under accession number ATCC 98915; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yl4 — 1 deposited under accession number ATCC 98915; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yl4 — 1 deposited under accession number ATCC 98915; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yl4 — 1 deposited under accession number ATCC 98915; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:150; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:150 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:150; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:149. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:149 from nucleotide 325 to nucleotide 984; the nucleotide sequence of SEQ ID NO:149 from nucleotide 973 to nucleotide 984; the nucleotide sequence of the full-length protein coding sequence of clone yl4 — 1 deposited under accession number ATCC 98915; or the nucleotide sequence of a mature protein coding sequence of clone yl4 — 1 deposited under accession number ATCC 98915. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yl4 — 1 deposited under accession number ATCC 98915. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:150 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:150, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:150 having biological activity, the fragment comprising the amino acid sequence from amino acid 105 to amino acid 114 of SEQ ID NO:150. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:149. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:149, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:149; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yl4 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:149, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:149; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yl4 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:149, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:149 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:149, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:149. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:149 from nucleotide 325 to nucleotide 984, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:149 from nucleotide 325 to nucleotide 984, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:149 from nucleotide 325 to nucleotide 984. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:149 from nucleotide 973 to nucleotide 984, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:149 from nucleotide 973 to nucleotide 984, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO: 149 from nucleotide 973 to nucleotide 984. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:150; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:150, the fragment comprising eight contiguous amino acids of SEQ ID NO:150; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yl4 — 1 deposited under accession number ATCC 98915; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:150. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:150 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:150, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:150 having biological activity, the fragment comprising the amino acid sequence from amino acid 105 to amino acid 114 of SEQ ID NO:150. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:151; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:151 from nucleotide 119 to nucleotide 415; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yl14 — 1 deposited under accession number ATCC 98915; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yl14 — 1 deposited under accession number ATCC 98915; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yl14 — 1 deposited under accession number ATCC 98915; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yl14 — 1 deposited under accession number ATCC 98915; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:152; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:152 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:152; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:151. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:151 from nucleotide 119 to nucleotide 415; the nucleotide sequence of the full-length protein coding sequence of clone yl14 — 1 deposited under accession number ATCC 98915; or the nucleotide sequence of a mature protein coding sequence of clone yl14 — 1 deposited under accession number ATCC 98915. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yl14 — 1 deposited under accession number ATCC 98915. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:152 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:152, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:152 having biological activity, the fragment comprising the amino acid sequence from amino acid 44 to amino acid 53 of SEQ ID NO:152. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:151. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:151, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:151; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yl14 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:151, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:151; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yl14 — 1 deposited under accession number ATCC 98915; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:151, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:151 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:151, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:151. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:151 from nucleotide 119 to nucleotide 415, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:151 from nucleotide 119 to nucleotide 415, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:151 from nucleotide 119 to nucleotide 415. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:152; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:152, the fragment comprising eight contiguous amino acids of SEQ ID NO:152; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yl14 — 1 deposited under accession number ATCC 98915; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:152. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:152 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:152, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:152 having biological activity, the fragment comprising the amino acid sequence from amino acid 44 to amino acid 53 of SEQ ID NO:152. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:153; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:153 from nucleotide 96 to nucleotide 377; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:153 from nucleotide 225 to nucleotide 377; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ya80 — 1 deposited under accession number ATCC 98925; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ya80 — 1 deposited under accession number ATCC 98925; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ya80 — 1 deposited under accession number ATCC 98925; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ya80 — 1 deposited under accession number ATCC 98925; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:154; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:154 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:154; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:153. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:153 from nucleotide 96 to nucleotide 377; the nucleotide sequence of SEQ ID NO:153 from nucleotide 225 to nucleotide 377; the nucleotide sequence of the full-length protein coding sequence of clone ya80 — 1 deposited under accession number ATCC 98925; or the nucleotide sequence of a mature protein coding sequence of clone ya80 — 1 deposited under accession number ATCC 98925. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ya80 — 1 deposited under accession number ATCC 98925. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:154 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:154, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:154 having biological activity, the fragment comprising the amino acid sequence from amino acid 42 to amino acid 51 of SEQ ID NO:154. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:153. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:153, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:153; and 
     (ab) the nucleotide sequence of the cDNA insert of done ya80 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:153, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:153; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ya80 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:153, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:153 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:153, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:153. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:153 from nucleotide 96 to nucleotide 377, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:153 from nucleotide 96 to nucleotide 377, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:153 from nucleotide 96 to nucleotide 377. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:153 from nucleotide 225 to nucleotide 377, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:153 from nucleotide 225 to nucleotide 377, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:153 from nucleotide 225 to nucleotide 377. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:154; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:154, the fragment comprising eight contiguous amino acids of SEQ ID NO:154; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ya80 — 1 deposited under accession number ATCC 98925; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:154. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:154 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:154, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:154 having biological activity, the fragment comprising the amino acid sequence from amino acid 42 to amino acid 51 of SEQ ID NO:154. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:155; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:155 from nucleotide 118 to nucleotide 681; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:155 from nucleotide 622 to nucleotide 681; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd61 — 1 deposited under accession number ATCC 98925; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd61 — 1 deposited under accession number ATCC 98925; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd61 — 1 deposited under accession number ATCC 98925; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd61 — 1 deposited under accession number ATCC 98925; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:156; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:156 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:156; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:155. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:155 from nucleotide 118 to nucleotide 681; the nucleotide sequence of SEQ ID NO:155 from nucleotide 622 to nucleotide 681; the nucleotide sequence of the full-length protein coding sequence of clone yd61 — 1 deposited under accession number ATCC 98925; or the nucleotide sequence of a mature protein coding sequence of clone yd61 — 1 deposited under accession number ATCC 98925. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd61 — 1 deposited under accession number ATCC 98925. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:156 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:156, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:156 having biological activity, the fragment comprising the amino acid sequence from amino acid 89 to amino acid 98 of SEQ ID NO:156. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:155. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:155, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:155; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd61 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:155, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:155; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd61 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:155, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:155 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:155, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:155. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:155 from nucleotide 118 to nucleotide 681, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:155 from nucleotide 118 to nucleotide 681, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:155 from nucleotide 118 to nucleotide 681. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:155 from nucleotide 622 to nucleotide 681, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:155 from nucleotide 622 to nucleotide 681, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:155 from nucleotide 622 to nucleotide 681. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:156; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:156, the fragment comprising eight contiguous amino acids of SEQ ID NO:156; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd61 — 1 deposited under accession number ATCC 98925; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:156. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:156 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:156, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:156 having biological activity, the fragment comprising the amino acid sequence from amino acid 89 to amino acid 98 of SEQ ID NO:156. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:157; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:157 from nucleotide 261 to nucleotide 614; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd88 — 1 deposited under accession number ATCC 98925; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd88 — 1 deposited under accession number ATCC 98925; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd88 — 1 deposited under accession number ATCC 98925; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd88 — 1 deposited under accession number ATCC 98925; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:158; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:158 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:158; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:157. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:157 from nucleotide 261 to nucleotide 614; the nucleotide sequence of the full-length protein coding sequence of clone yd88 — 1 deposited under accession number ATCC 98925; or the nucleotide sequence of a mature protein coding sequence of clone yd88 — 1 deposited under accession number ATCC 98925. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd88 — 1 deposited under accession number ATCC 98925. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:158 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:158, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:158 having biological activity, the fragment comprising the amino acid sequence from amino acid 54 to amino acid 63 of SEQ ID NO:158. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:157. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:157, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:157; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd88 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:157, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:157; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd88 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:157, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:157 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:157, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:157. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:157 from nucleotide 261 to nucleotide 614, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:157 from nucleotide 261 to nucleotide 614, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:157 from nucleotide 261 to nucleotide 614. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:158; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:158, the fragment comprising eight contiguous amino acids of SEQ ID NO:158; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd88 — 1 deposited under accession number ATCC 98925; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:158. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:158 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:158, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:158 having biological activity, the fragment comprising the amino acid sequence from amino acid 54 to amino acid 63 of SEQ ID NO:158. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:159; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:159 from nucleotide 26 to nucleotide 475; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd109 — 1 deposited under accession number ATCC 98925; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd109 — 1 deposited under accession number ATCC 98925; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd109 — 1 deposited under accession number ATCC 98925; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd109 — 1 deposited under accession number ATCC 98925; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:160; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:160 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:160; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:159. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:159 from nucleotide 26 to nucleotide 475; the nucleotide sequence of the full-length protein coding sequence of clone yd109 — 1 deposited under accession number ATCC 98925; or the nucleotide sequence of a mature protein coding sequence of clone yd109 — 1 deposited under accession number ATCC 98925. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd109 — 1 deposited under accession number ATCC 98925. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:160 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:160, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:160 having biological activity, the fragment comprising the amino acid sequence from amino acid 70 to amino acid 79 of SEQ ID NO:160. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:159. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:159, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:159; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd109 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:159, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:159; and 
     (bb) the nucleotide sequence of the cDNA insert of done yd109 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:159, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:159 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:159, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:159. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:159 from nucleotide 26 to nucleotide 475, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:159 from nucleotide 26 to nucleotide 475, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:159 from nucleotide 26 to nucleotide 475. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:160; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:160, the fragment comprising eight contiguous amino acids of SEQ ID NO:160; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd109 — 1 deposited under accession number ATCC 98925; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:160. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:160 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:160, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:160 having biological activity, the fragment comprising the amino acid sequence from amino acid 70 to amino acid 79 of SEQ ID NO:160. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:161; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:161 from nucleotide 79 to nucleotide 474; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd141 — 1 deposited under accession number ATCC 98925; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd141 — 1 deposited under accession number ATCC 98925; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd141 — 1 deposited under accession number ATCC 98925; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd141 — 1 deposited under accession number ATCC 98925; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:162; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:162 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:162; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:161. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:161 from nucleotide 79 to nucleotide 474; the nucleotide sequence of the full-length protein coding sequence of clone yd141 — 1 deposited under accession number ATCC 98925; or the nucleotide sequence of a mature protein coding sequence of clone yd141 — 1 deposited under accession number ATCC 98925. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd141 — 1 deposited under accession number ATCC 98925. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:162 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:162, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:162 having biological activity, the fragment comprising the amino acid sequence from amino acid 61 to amino acid 70 of SEQ ID NO:162. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:161. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:161, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:161; and 
     (ab) the nucleotide sequence of the cDNA insert of done yd141 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:161, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:161; and 
     (bb) the nucleotide sequence of the cDNA insert of done yd141 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:161, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:161 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:161, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:161. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:161 from nucleotide 79 to nucleotide 474, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:161 from nucleotide 79 to nucleotide 474, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:161 from nucleotide 79 to nucleotide 474. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:162; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:162, the fragment comprising eight contiguous amino acids of SEQ ID NO:162; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd141 — 1 deposited under accession number ATCC 98925; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:162. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:162 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:162, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:162 having biological activity, the fragment comprising the amino acid sequence from amino acid 61 to amino acid 70 of SEQ ID NO:162. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:163; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:163 from nucleotide 45 to nucleotide 347; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:163 from nucleotide 135 to nucleotide 347; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd153 — 1 deposited under accession number ATCC 98925; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd153 — 1 deposited under accession number ATCC 98925; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd153 — 1 deposited under accession number ATCC 98925; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd153 — 1 deposited under accession number ATCC 98925; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:164; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:164 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:164; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:163. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:163 from nucleotide 45 to nucleotide 347; the nucleotide sequence of SEQ ID NO:163 from nucleotide 135 to nucleotide 347; the nucleotide sequence of the full-length protein coding sequence of clone yd153 — 1 deposited under accession number ATCC 98925; or the nucleotide sequence of a mature protein coding sequence of clone yd153 — 1 deposited under accession number ATCC 98925. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd153 — 1 deposited under accession number ATCC 98925. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:164 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:164, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:164 having biological activity, the fragment comprising the amino acid sequence from amino acid 45 to amino acid 54 of SEQ ID NO:164. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:163. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:163, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:163; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd153 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:163, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:163; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd153 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:163, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:163 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:163, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:163. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:163 from nucleotide 45 to nucleotide 347, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:163 from nucleotide 45 to nucleotide 347, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:163 from nucleotide 45 to nucleotide 347. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:163 from nucleotide 135 to nucleotide 347, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:163 from nucleotide 135 to nucleotide 347, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:163 from nucleotide 135 to nucleotide 347. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:164; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:164, the fragment comprising eight contiguous amino acids of SEQ ID NO:164; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd153 — 1 deposited under accession number ATCC 98925; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:164. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:164 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:164, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:164 having biological activity, the fragment comprising the amino acid sequence from amino acid 45 to amino acid 54 of SEQ ID NO:164. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:165; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:165 from nucleotide 114 to nucleotide 470; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd165 — 1 deposited under accession number ATCC 98925; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd165 — 1 deposited under accession number ATCC 98925; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd165 — 1 deposited under accession number ATCC 98925; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd165 — 1 deposited under accession number ATCC 98925; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:166; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:166 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:166; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:165. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:165 from nucleotide 114 to nucleotide 470; the nucleotide sequence of the full-length protein coding sequence of clone yd165 — 1 deposited under accession number ATCC 98925; or the nucleotide sequence of a mature protein coding sequence of clone yd165 — 1 deposited under accession number ATCC 98925. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd165 — 1 deposited under accession number ATCC 98925. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:166 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:166, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:166 having biological activity, the fragment comprising the amino acid sequence from amino acid 54 to amino acid 63 of SEQ ID NO:166. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:165. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:165, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:165; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd165 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:165, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:165; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd165 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:165, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:165 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:165, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:165. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:165 from nucleotide 114 to nucleotide 470, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:165 from nucleotide 114 to nucleotide 470, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:165 from nucleotide 114 to nucleotide 470. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:166; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:166, the fragment comprising eight contiguous amino acids of SEQ ID NO:166; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd165 — 1 deposited under accession number ATCC 98925; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:166. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:166 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:166, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:166 having biological activity, the fragment comprising the amino acid sequence from amino acid 54 to amino acid 63 of SEQ ID NO:166. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:167; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:167 from nucleotide 82 to nucleotide 663; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:167 from nucleotide 139 to nucleotide 663; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd178 — 1 deposited under accession number ATCC 98925; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd178 — 1 deposited under accession number ATCC 98925; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd178 — 1 deposited under accession number ATCC 98925; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd178 — 1 deposited under accession number ATCC 98925; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:168; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:168 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:168; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:167. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:167 from nucleotide 82 to nucleotide 663; the nucleotide sequence of SEQ ID NO:167 from nucleotide 139 to nucleotide 663; the nucleotide sequence of the full-length protein coding sequence of clone yd178 — 1 deposited under accession number ATCC 98925; or the nucleotide sequence of a mature protein coding sequence of clone yd178 — 1 deposited under accession number ATCC 98925. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd178 — 1 deposited under accession number ATCC 98925. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:168 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:168, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:168 having biological activity, the fragment comprising the amino acid sequence from amino acid 92 to amino acid 101 of SEQ ID NO:168. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:167. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:167, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:167; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd178 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:167, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:167; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd178 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:167, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:167 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:167, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:167. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:167 from nucleotide 82 to nucleotide 663, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:167 from nucleotide 82 to nucleotide 663, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:167 from nucleotide 82 to nucleotide 663. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:167 from nucleotide 139 to nucleotide 663, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:167 from nucleotide 139 to nucleotide 663, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:167 from nucleotide 139 to nucleotide 663. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:168; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:168, the fragment comprising eight contiguous amino acids of SEQ ID NO:168; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd178 — 1 deposited under accession number ATCC 98925; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:168. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:168 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:168, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:168 having biological activity, the fragment comprising the amino acid sequence from amino acid 92 to amino acid 101 of SEQ ID NO:168. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:169; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:169 from nucleotide 121 to nucleotide 450; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd191 — 1 deposited under accession number ATCC 98925; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd191 — 1 deposited under accession number ATCC 98925; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd191 — 1 deposited under accession number ATCC 98925; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd191 — 1 deposited under accession number ATCC 98925; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO: 170; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:170 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:170; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:169. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO: 169 from nucleotide 121 to nucleotide 450; the nucleotide sequence of the full length protein coding sequence of clone yd191 — 1 deposited under accession number ATCC 98925; or the nucleotide sequence of a mature protein coding sequence of clone yd191 — 1 deposited under accession number ATCC 98925. In other preferred embodiments, the polynucleotide encodes the full length or a mature protein encoded by the cDNA insert of clone yd191 — 1 deposited under accession number ATCC 98925. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:170 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:170, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:170 having biological activity, the fragment comprising the amino acid sequence from amino acid 50 to amino acid 59 of SEQ ID NO:170. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:169. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:169, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:169; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd191 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:169, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:169; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd191 — 1 deposited under accession number ATCC 98925; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:169, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:169 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:169, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:169. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:169 from nucleotide 121 to nucleotide 450, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:169 from nucleotide 121 to nucleotide 450, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:169 from nucleotide 121 to nucleotide 450. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:170; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:170, the fragment comprising eight contiguous amino acids of SEQ ID NO:170; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd191 — 1 deposited under accession number ATCC 98925; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:170. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:170 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:170, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:170 having biological activity, the fragment comprising the amino acid sequence from amino acid 50 to amino acid 59 of SEQ ID NO:170. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:171; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:171 from nucleotide 33 to nucleotide 494; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ye7 — 1 deposited under accession number ATCC 98924; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ye7 — 1 deposited under accession number ATCC 98924; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ye7 — 1 deposited under accession number ATCC 98924; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ye7 — 1 deposited under accession number ATCC 98924; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:172; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:172 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:172; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:171. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:171 from nucleotide 33 to nucleotide 494; the nucleotide sequence of the full-length protein coding sequence of clone ye7 — 1 deposited under accession number ATCC 98924; or the nucleotide sequence of a mature protein coding sequence of clone ye7 — 1 deposited under accession number ATCC 98924. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ye7 — 1 deposited under accession number ATCC 98924. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:172 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:172, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:172 having biological activity, the fragment comprising the amino acid sequence from amino acid 72 to amino acid 81 of SEQ ID NO:172. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:171. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:171, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:171; and 
     (ab) the nucleotide sequence of the cDNA insert of done ye7 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:171, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:171; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ye7 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:171, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:171 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:171, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:171. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:171 from nucleotide 33 to nucleotide 494, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:171 from nucleotide 33 to nucleotide 494, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:171 from nucleotide 33 to nucleotide 494. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:172; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:172, the fragment comprising eight contiguous amino acids of SEQ ID NO:172; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ye7 — 1 deposited under accession number ATCC 98924; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:172. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:172 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:172, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:172 having biological activity, the fragment comprising the amino acid sequence from amino acid 72 to amino acid 81 of SEQ ID NO:172. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:173; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:173 from nucleotide 1251 to nucleotide 1625; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:173 from nucleotide 1395 to nucleotide 1625; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yf33 — 1 deposited under accession number ATCC 98924; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yf33 — 1 deposited under accession number ATCC 98924; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yf33 — 1 deposited under accession number ATCC 98924; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yf33 — 1 deposited under accession number ATCC 98924; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:174; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:174 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:174; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:173. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:173 from nucleotide 1251 to nucleotide 1625; the nucleotide sequence of SEQ ID NO:173 from nucleotide 1395 to nucleotide 1625; the nucleotide sequence of the full-length protein coding sequence of done yf33 — 1 deposited under accession number ATCC 98924; or the nucleotide sequence of a mature protein coding sequence of clone yf33 — 1 deposited under accession number ATCC 98924. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yf33 — 1 deposited under accession number ATCC 98924. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:174 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:174, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:174 having biological activity, the fragment comprising the amino acid sequence from amino acid 57 to amino acid 66 of SEQ ID NO:174. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:173. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:173, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:173; and 
     (ab) the nucleotide sequence of the cDNA insert of done yf33 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:173, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:173; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yf33 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:173, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:173 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:173, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:173. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:173 from nucleotide 1251 to nucleotide 1625, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:173 from nucleotide 1251 to nucleotide 1625, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:173 from nucleotide 1251 to nucleotide 1625. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:173 from nucleotide 1395 to nucleotide 1625, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:173 from nucleotide 1395 to nucleotide 1625, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:173 from nucleotide 1395 to nucleotide 1625. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:174; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:174, the fragment comprising eight contiguous amino acids of SEQ ID NO:174; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yf33 — 1 deposited under accession number ATCC 98924; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:174. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:174 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:174, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:174 having biological activity, the fragment comprising the amino acid sequence from amino acid 57 to amino acid 66 of SEQ ID NO:174. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:175; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:175 from nucleotide 1299 to nucleotide 1640; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yi15 — 1 deposited under accession number ATCC 98924; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yi15 — 1 deposited under accession number ATCC 98924; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yi15 — 1 deposited under accession number ATCC 98924; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yi15 — 1 deposited under accession number ATCC 98924; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:176; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:176 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:176; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:175. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:175 from nucleotide 1299 to nucleotide 1640; the nucleotide sequence of the full-length protein coding sequence of clone yi15 — 1 deposited under accession number ATCC 98924; or the nucleotide sequence of a mature protein coding sequence of clone yi15 — 1 deposited under accession number ATCC 98924. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yi15 — 1 deposited under accession number ATCC 98924. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:176 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:176, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:176 having biological activity, the fragment comprising the amino acid sequence from amino acid 52 to amino acid 61 of SEQ ID NO:176. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:175. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:175, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:175; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yi15 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:175, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:175; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yi15 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:175, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:175 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:175, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:175. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:175 from nucleotide 1299 to nucleotide 1640, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:175 from nucleotide 1299 to nucleotide 1640, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:175 from nucleotide 1299 to nucleotide 1640. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:176; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:176, the fragment comprising eight contiguous amino acids of SEQ ID NO:176; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yi15 — 1 deposited under accession number ATCC 98924; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:176. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:176 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:176, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:176 having biological activity, the fragment comprising the amino acid sequence from amino acid 52 to amino acid 61 of SEQ ID NO:176. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:177; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:177 from nucleotide 85 to nucleotide 1377; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:177 from nucleotide 139 to nucleotide 1377; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of done yi17 — 1 deposited under accession number ATCC 98924; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yi17 — 1 deposited under accession number ATCC 98924; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yi17 — 1 deposited under accession number ATCC 98924; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yi17 — 1 deposited under accession number ATCC 98924; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:178; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:178 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:178; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:177. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:177 from nucleotide 85 to nucleotide 1377; the nucleotide sequence of SEQ ID NO:177 from nucleotide 139 to nucleotide 1377; the nucleotide sequence of the full-length protein coding sequence of clone yi17 — 1 deposited under accession number ATCC 98924; or the nucleotide sequence of a mature protein coding sequence of clone yi17 — 1 deposited under accession number ATCC 98924. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yi17 — 1 deposited under accession number ATCC 98924. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:178 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:178, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:178 having biological activity, the fragment comprising the amino acid sequence from amino acid 210 to amino acid 219 of SEQ ID NO:178. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:177. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:177, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:177; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yi17 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:177, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:177; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yi17 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:177, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:177 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:177, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:177. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:177 from nucleotide 85 to nucleotide 1377, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:177 from nucleotide 85 to nucleotide 1377, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:177 from nucleotide 85 to nucleotide 1377. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:177 from nucleotide 139 to nucleotide 1377, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:177 from nucleotide 139 to nucleotide 1377, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:177 from nucleotide 139 to nucleotide 1377. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:178; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:178, the fragment comprising eight contiguous amino acids of SEQ ID NO:178; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yi17 — 1 deposited under accession number ATCC 98924; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:178. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:178 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:178, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:178 having biological activity, the fragment comprising the amino acid sequence from amino acid 210 to amino acid 219 of SEQ ID NO:178. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:179; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:179 from nucleotide 50 to nucleotide 1075; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:179 from nucleotide 215 to nucleotide 1075; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk38 — 1 deposited under accession number ATCC 98924; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk38 — 1 deposited under accession number ATCC 98924; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk38 — 1 deposited under accession number ATCC 98924; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk38 — 1 deposited under accession number ATCC 98924; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:180; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:180 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:180; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:179. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:179 from nucleotide 50 to nucleotide 1075; the nucleotide sequence of SEQ ID NO:179 from nucleotide 215 to nucleotide 1075; the nucleotide sequence of the full-length protein coding sequence of clone yk38 — 1 deposited under accession number ATCC 98924; or the nucleotide sequence of a mature protein coding sequence of clone yk38 — 1 deposited under accession number ATCC 98924. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk38 — 1 deposited under accession number ATCC 98924. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:180 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:180, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:180 having biological activity, the fragment comprising the amino acid sequence from amino acid 166 to amino acid 175 of SEQ ID NO:180. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:179. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:179, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:179; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk38 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:179, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:179; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk38 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:179, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:179 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:179, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:179. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:179 from nucleotide 50 to nucleotide 1075, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:179 from nucleotide 50 to nucleotide 1075, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:179 from nucleotide 50 to nucleotide 1075. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:179 from nucleotide 215 to nucleotide 1075, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:179 from nucleotide 215 to nucleotide 1075, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:179 from nucleotide 215 to nucleotide 1075. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:180; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:180, the fragment comprising eight contiguous amino acids of SEQ ID NO:180; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk38 — 1 deposited under accession number ATCC 98924; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:180. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:180 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:180, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:180 having biological activity, the fragment comprising the amino acid sequence from amino acid 166 to amino acid 175 of SEQ ID NO:180. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:181; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:181 from nucleotide 76 to nucleotide 348; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:181 from nucleotide 139 to nucleotide 348; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk51 — 1 deposited under accession number ATCC 98924; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk51 — 1 deposited under accession number ATCC 98924; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk51 — 1 deposited under accession number ATCC 98924; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk51 — 1 deposited under accession number ATCC 98924; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:182; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:182 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:182; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:181. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:181 from nucleotide 76 to nucleotide 348; the nucleotide sequence of SEQ ID NO:181 from nucleotide 139 to nucleotide 348; the nucleotide sequence of the full-length protein coding sequence of clone yk51 — 1 deposited under accession number ATCC 98924; or the nucleotide sequence of a mature protein coding sequence of clone yk51 — 1 deposited under accession number ATCC 98924. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk51 — 1 deposited under accession number ATCC 98924. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:182 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:182, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:182 having biological activity, the fragment comprising the amino acid sequence from amino acid 40 to amino acid 49 of SEQ ID NO:182. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:181. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:181, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:181; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk51 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:181, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:181; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk51 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:181, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:181 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:181, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:181. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:181 from nucleotide 76 to nucleotide 348, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:181 from nucleotide 76 to nucleotide 348, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:181 from nucleotide 76 to nucleotide 348. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:181 from nucleotide 139 to nucleotide 348, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:181 from nucleotide 139 to nucleotide 348, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:181 from nucleotide 139 to nucleotide 348. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:182; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:182, the fragment comprising eight contiguous amino acids of SEQ ID NO:182; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk51 — 1 deposited under accession number ATCC 98924; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:182. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:182 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:182, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:182 having biological activity, the fragment comprising the amino acid sequence from amino acid 40 to amino acid 49 of SEQ ID NO:182. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:183; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:183 from nucleotide 203 to nucleotide 577; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk74 — 1 deposited under accession number ATCC 98924; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk74 — 1 deposited under accession number ATCC 98924; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk74 — 1 deposited under accession number ATCC 98924; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk74 — 1 deposited under accession number ATCC 98924; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:184; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:184 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:184; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:183. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:183 from nucleotide 203 to nucleotide 577; the nucleotide sequence of the full-length protein coding sequence of clone yk74 — 1 deposited under accession number ATCC 98924; or the nucleotide sequence of a mature protein coding sequence of clone yk74 — 1 deposited under accession number ATCC 98924. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk74 — 1 deposited under accession number ATCC 98924. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:184 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:184, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:184 having biological activity, the fragment comprising the amino acid sequence from amino acid 57 to amino acid 66 of SEQ ID NO:184. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:183. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:183, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:183; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk74 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:183, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:183; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk74 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:183, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:183 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:183, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:183. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:183 from nucleotide 203 to nucleotide 577, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:183 from nucleotide 203 to nucleotide 577, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:183 from nucleotide 203 to nucleotide 577. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:184; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:184, the fragment comprising eight contiguous amino acids of SEQ ID NO:184; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk74 — 1 deposited under accession number ATCC 98924; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:184. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:184 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:184, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:184 having biological activity, the fragment comprising the amino acid sequence from amino acid 57 to amino acid 66 of SEQ ID NO:184. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:185; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:185 from nucleotide 38 to nucleotide 2170; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk89 — 1 deposited under accession number ATCC 98924; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk89 — 1 deposited under accession number ATCC 98924; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk89 — 1 deposited under accession number ATCC 98924; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk89 — 1 deposited under accession number ATCC 98924; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:186; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:186 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:186; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:185. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:185 from nucleotide 38 to nucleotide 2170; the nucleotide sequence of the full-length protein coding sequence of clone yk89 — 1 deposited under accession number ATCC 98924; or the nucleotide sequence of a mature protein coding sequence of clone yk89 — 1 deposited under accession number ATCC 98924. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk89 — 1 deposited under accession number ATCC 98924. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:186 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:186, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:186 having biological activity, the fragment comprising the amino acid sequence from amino acid 350 to amino acid 359 of SEQ ID NO:186. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:185. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:185, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:185; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk89 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:185, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:185; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk89 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:185, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:185 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:185, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:185. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:185 from nucleotide 38 to nucleotide 2170, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:185 from nucleotide 38 to nucleotide 2170, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:185 from nucleotide 38 to nucleotide 2170. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:186; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:186, the fragment comprising eight contiguous amino acids of SEQ ID NO:186; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk89 — 1 deposited under accession number ATCC 98924; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:186. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:186 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:186, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:186 having biological activity, the fragment comprising the amino acid sequence from amino acid 350 to amino acid 359 of SEQ ID NO:186. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:187; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:187 from nucleotide 14 to nucleotide 742; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:187 from nucleotide 89 to nucleotide 742; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of done yl18 — 1 deposited under accession number ATCC 98924; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yl18 — 1 deposited under accession number ATCC 98924; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yl18 — 1 deposited under accession number ATCC 98924; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yl18 — 1 deposited under accession number ATCC 98924; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:188; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:188 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:188; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:187. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:187 from nucleotide 14 to nucleotide 742; the nucleotide sequence of SEQ ID NO:187 from nucleotide 89 to nucleotide 742; the nucleotide sequence of the full-length protein coding sequence of clone yl18 — 1 deposited under accession number ATCC 98924; or the nucleotide sequence of a mature protein coding sequence of clone yl18 — 1 deposited under accession number ATCC 98924. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yl18 — 1 deposited under accession number ATCC 98924. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:188 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:188, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:188 having biological activity, the fragment comprising the amino acid sequence from amino acid 116 to amino acid 125 of SEQ ID NO:188. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:187. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:187, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:187; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yl18 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:187, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:187; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yl18 — 1 deposited under accession number ATCC 98924; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:187, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:187 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:187, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:187. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:187 from nucleotide 14 to nucleotide 742, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:187 from nucleotide 14 to nucleotide 742, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:187 from nucleotide 14 to nucleotide 742. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:187 from nucleotide 89 to nucleotide 742, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:187 from nucleotide 89 to nucleotide 742, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:187 from nucleotide 89 to nucleotide 742. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:188; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:188, the fragment comprising eight contiguous amino acids of SEQ ID NO:188; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yl18 — 1 deposited under accession number ATCC 98924; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:188. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:188 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:188, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:188 having biological activity, the fragment comprising the amino acid sequence from amino acid 116 to amino acid 125 of SEQ ID NO:188. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:189; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:189 from nucleotide 280 to nucleotide 615; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:189 from nucleotide 325 to nucleotide 615; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yb325 — 1 deposited under accession number ATCC 98958; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yb325 — 1 deposited under accession number ATCC 98958; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yb325 — 1 deposited under accession number ATCC 98958; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yb325 — 1 deposited under accession number ATCC 98958; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:190; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:190 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:190; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:189. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:189 from nucleotide 280 to nucleotide 615; the nucleotide sequence of SEQ ID NO:189 from nucleotide 325 to nucleotide 615; the nucleotide sequence of the full-length protein coding sequence of clone yb325 — 1 deposited under accession number ATCC 98958; or the nucleotide sequence of a mature protein coding sequence of clone yb325 — 1 deposited under accession number ATCC 98958. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yb325 — 1 deposited under accession number ATCC 98958. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:190 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:190, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:190 having biological activity, the fragment comprising the amino acid sequence from amino acid 51 to amino acid 60 of SEQ ID NO:190. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:189. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:189; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yb325 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:189; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yb325 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:189, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:189 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:189. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:189 from nucleotide 280 to nucleotide 615, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:189 from nucleotide 280 to nucleotide 615, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:189 from nucleotide 280 to nucleotide 615. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:189 from nucleotide 325 to nucleotide 615, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:189 from nucleotide 325 to nucleotide 615, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:189 from nucleotide 325 to nucleotide 615. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:190; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:190, the fragment comprising eight contiguous amino acids of SEQ ID NO:190; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yb325 — 1 deposited under accession number ATCC 98958; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:190. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:190 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:190, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:190 having biological activity, the fragment comprising the amino acid sequence from amino acid 51 to amino acid 60 of SEQ ID NO:190. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:191; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:191 from nucleotide 163 to nucleotide 429; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:191 from nucleotide 274 to nucleotide 429; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yd261 — 1 deposited under accession number ATCC 98958; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yd261 — 1 deposited under accession number ATCC 98958; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yd261 — 1 deposited under accession number ATCC 98958; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yd261 — 1 deposited under accession number ATCC 98958; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:192; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:192 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:192; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:191. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:191 from nucleotide 163 to nucleotide 429; the nucleotide sequence of SEQ ID NO:191 from nucleotide 274 to nucleotide 429; the nucleotide sequence of the full-length protein coding sequence of clone yd261 — 1 deposited under accession number ATCC 98958; or the nucleotide sequence of a mature protein coding sequence of clone yd261 — 1 deposited under accession number ATCC 98958. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yd261 — 1 deposited under accession number ATCC 98958. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:192 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:192, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:192 having biological activity, the fragment comprising the amino acid sequence from amino acid 39 to amino acid 48 of SEQ ID NO:192. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:191. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:191, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:191; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yd261 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:191, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:191; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yd261 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:191, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:191 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:191, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:191. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:191 from nucleotide 163 to nucleotide 429, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:191 from nucleotide 163 to nucleotide 429, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:191 from nucleotide 163 to nucleotide 429. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:191 from nucleotide 274 to nucleotide 429, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:191 from nucleotide 274 to nucleotide 429, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:191 from nucleotide 274 to nucleotide 429. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:192; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:192, the fragment comprising eight contiguous amino acids of SEQ ID NO:192; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yd261 — 1 deposited under accession number ATCC 98958; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:192. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:192 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:192, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:192 having biological activity, the fragment comprising the amino acid sequence from amino acid 39 to amino acid 48 of SEQ ID NO:192. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:193; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:193 from nucleotide 1262 to nucleotide 1858; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yh33 — 1 deposited under accession number ATCC 98958; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yh33 — 1 deposited under accession number ATCC 98958; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yh33 — 1 deposited under accession number ATCC 98958; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yh33 — 1 deposited under accession number ATCC 98958; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:194; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:194 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:194; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:193. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:193 from nucleotide 1262 to nucleotide 1858; the nucleotide sequence of the full-length protein coding sequence of clone yh33 — 1 deposited under accession number ATCC 98958; or the nucleotide sequence of a mature protein coding sequence of clone yh33 — 1 deposited under accession number ATCC 98958. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yh33 — 1 deposited under accession number ATCC 98958. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:194 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:194, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:194 having biological activity, the fragment comprising the amino acid sequence from amino acid 94 to amino acid 103 of SEQ ID NO:194. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:193. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:193, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:193; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yh33 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:193, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:193; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yh33 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:193, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:193 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:193, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:193. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:193 from nucleotide 1262 to nucleotide 1858, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:193 from nucleotide 1262 to nucleotide 1858, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:193 from nucleotide 1262 to nucleotide 1858. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:194; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:194, the fragment comprising eight contiguous amino acids of SEQ ID NO:194; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yh33 — 1 deposited under accession number ATCC 98958; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:194. In further preferred embodiments; the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:194 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:194, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:194 having biological activity, the fragment comprising the amino acid sequence from amino acid 94 to amino acid 103 of SEQ ID NO:194. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:195; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:195 from nucleotide 25 to nucleotide 1851; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:195 from nucleotide 250 to nucleotide 1851; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yi16 — 1 deposited under accession number ATCC 98958; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yi16 — 1 deposited under accession number ATCC 98958; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yi16 — 1 deposited under accession number ATCC 98958; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yi16 — 1 deposited under accession number ATCC 98958; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:196; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:196 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:196; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:195. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:195 from nucleotide 25 to nucleotide 1851; the nucleotide sequence of SEQ ID NO:195 from nucleotide 250 to nucleotide 1851; the nucleotide sequence of the full-length protein coding sequence of clone yi16 — 1 deposited under accession number ATCC 98958; or the nucleotide sequence of a mature protein coding sequence of clone yi16 — 1 deposited under accession number ATCC 98958. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yi16 — 1 deposited under accession number ATCC 98958. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:196 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:196, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:196 having biological activity, the fragment comprising the amino acid sequence from amino acid 299 to amino acid 308 of SEQ ID NO:196. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:195. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:195, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:195; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yi16 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:195, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:195; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yi16 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:195, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:195 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:195, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:195. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:195 from nucleotide 25 to nucleotide 1851, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:195 from nucleotide 25 to nucleotide 1851, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:195 from nucleotide to nucleotide 1851. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:195 from nucleotide 250 to nucleotide 1851, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:195 from nucleotide 250 to nucleotide 1851, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:195 from nucleotide 250 to nucleotide 1851. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:196; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:196, the fragment comprising eight contiguous amino acids of SEQ ID NO:196; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yi16 — 1 deposited under accession number ATCC 98958; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:196. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:196 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:196, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:196 having biological activity, the fragment comprising the amino acid sequence from amino acid 299 to amino acid 308 of SEQ ID NO:196. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:197; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:197 from nucleotide 739 to nucleotide 996; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk46 — 1 deposited under accession number ATCC 98958; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk46 — 1 deposited under accession number ATCC 98958; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk46 — 1 deposited under accession number ATCC 98958; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk46 — 1 deposited under accession number ATCC 98958; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:198; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:198 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:198; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:197. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:197 from nucleotide 739 to nucleotide 996; the nucleotide sequence of the full-length protein coding sequence of clone yk46 — 1 deposited under accession number ATCC 98958; or the nucleotide sequence of a mature protein coding sequence of clone yk46 — 1 deposited under accession number ATCC 98958. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk46 — 1 deposited under accession number ATCC 98958. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:198 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:198, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:198 having biological activity, the fragment comprising the amino acid sequence from amino acid 38 to amino acid 47 of SEQ ID NO:198. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:197. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:197, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:197; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk46 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:197, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:197; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk46 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:197, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:197 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:197, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:197. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:197 from nucleotide 739 to nucleotide 996, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:197 from nucleotide 739 to nucleotide 996, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:197 from nucleotide 739 to nucleotide 996. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:198; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:198, the fragment comprising eight contiguous amino acids of SEQ ID NO:198; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk46 — 1 deposited under accession number ATCC 98958; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:198. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:198 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:198, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:198 having biological activity, the fragment comprising the amino acid sequence from amino acid 38 to amino acid 47 of SEQ ID NO:198. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:199; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:199 from nucleotide 222 to nucleotide 605; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:199 from nucleotide 366 to nucleotide 605; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk84 — 1 deposited under accession number ATCC 98958; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk84 — 1 deposited under accession number ATCC 98958; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk84 — 1 deposited under accession number ATCC 98958; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk84 — 1 deposited under accession number ATCC 98958; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:200; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:200 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:200; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:199. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:199 from nucleotide 222 to nucleotide 605; the nucleotide sequence of SEQ ID NO:199 from nucleotide 366 to nucleotide 605; the nucleotide sequence of the full-length protein coding sequence of clone yk84 — 1 deposited under accession number ATCC 98958; or the nucleotide sequence of a mature protein coding sequence of clone yk84 — 1 deposited under accession number ATCC 98958. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk84 — 1 deposited under accession number ATCC 98958. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:200 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:200, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:200 having biological activity, the fragment comprising the amino acid sequence from amino acid 59 to amino acid 68 of SEQ ID NO:200. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:199. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:199, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:199; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk84 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:199, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:199; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk84 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:199, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:199 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:199, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:199. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:199 from nucleotide 222 to nucleotide 605, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:199 from nucleotide 222 to nucleotide 605, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:199 from nucleotide 222 to nucleotide 605. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:199 from nucleotide 366 to nucleotide 605, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:199 from nucleotide 366 to nucleotide 605, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:199 from nucleotide 366 to nucleotide 605. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:200; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:200, the fragment comprising eight contiguous amino acids of SEQ ID NO:200; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk84 — 1 deposited under accession number ATCC 98958; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:200. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:200 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:200, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:200 having biological activity, the fragment comprising the amino acid sequence from amino acid 59 to amino acid 68 of SEQ ID NO:200. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:201; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:201 from nucleotide 140 to nucleotide 1036; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:201 from nucleotide 269 to nucleotide 1036; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk143 — 1 deposited under accession number ATCC 98958; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk143 — 1 deposited under accession number ATCC 98958; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk143 — 1 deposited under accession number ATCC 98958; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk143 — 1 deposited under accession number ATCC 98958; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:202; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:202 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:202; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:201. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:201 from nucleotide 140 to nucleotide 1036; the nucleotide sequence of SEQ ID NO:201 from nucleotide 269 to nucleotide 1036; the nucleotide sequence of the full-length protein coding sequence of clone yk143 — 1 deposited under accession number ATCC 98958; or the nucleotide sequence of a mature protein coding sequence of clone yk143 — 1 deposited under accession number ATCC 98958. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk143 — 1 deposited under accession number ATCC 98958. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:202 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:202, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:202 having biological activity, the fragment comprising the amino acid sequence from amino acid 144 to amino acid 153 of SEQ ID NO:202. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:201. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:201, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:201; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk143 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:201, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:201; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk143 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:201, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:201 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:201, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:201. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:201 from nucleotide 140 to nucleotide 1036, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:201 from nucleotide 140 to nucleotide 1036, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:201 from nucleotide 140 to nucleotide 1036. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:201 from nucleotide 269 to nucleotide 1036, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:201 from nucleotide 269 to nucleotide 1036, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:201 from nucleotide 269 to nucleotide 1036. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:202; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:202, the fragment comprising eight contiguous amino acids of SEQ ID NO:202; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk143 — 1 deposited under accession number ATCC 98958; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:202. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:202 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:202, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:202 having biological activity, the fragment comprising the amino acid sequence from amino acid 144 to amino acid 153 of SEQ ID NO:202. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:203; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:203 from nucleotide 304 to nucleotide 636; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:203 from nucleotide 415 to nucleotide 636; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk156 — 1 deposited under accession number ATCC 98958; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk156 — 1 deposited under accession number ATCC 98958; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk156 — 1 deposited under accession number ATCC 98958; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk156 — 1 deposited under accession number ATCC 98958; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:204; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:204 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:204; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:203. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:203 from nucleotide 304 to nucleotide 636; the nucleotide sequence of SEQ ID NO:203 from nucleotide 415 to nucleotide 636; the nucleotide sequence of the full-length protein coding sequence of clone yk156 — 1 deposited under accession number ATCC 98958; or the nucleotide sequence of a mature protein coding sequence of clone yk156 — 1 deposited under accession number ATCC 98958. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk156 — 1 deposited under accession number ATCC 98958. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:204 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:204, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:204 having biological activity, the fragment comprising the amino acid sequence from amino acid 50 to amino acid 59 of SEQ ID NO:204. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:203. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:203, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:203; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk156 — 1 deposited under accession number ATCC 98958; 
     (i) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:203, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:203; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk156 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:203, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:203 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:203 but excluding the poly(A) tail at the 3′ end of SEQ ID NO:203. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:203 from nucleotide 304 to nucleotide 636, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:203 from nucleotide 304 to nucleotide 636, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:203 from nucleotide 304 to nucleotide 636. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:203 from nucleotide 415 to nucleotide 636, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:203 from nucleotide 415 to nucleotide 636, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:203 from nucleotide 415 to nucleotide 636. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:204; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:204, the fragment comprising eight contiguous amino acids of SEQ ID NO:204; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk156 — 1 deposited under accession number ATCC 98958; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:204. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:204 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:204, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:204 having biological activity, the fragment comprising the amino acid sequence from amino acid 50 to amino acid 59 of SEQ ID NO:204. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:205; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:205 from nucleotide 571 to nucleotide 891; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:205 from nucleotide 745 to nucleotide 891; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk204 — 1 deposited under accession number ATCC 98958; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk204 — 1 deposited under accession number ATCC 98958; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk204 — 1 deposited under accession number ATCC 98958; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk204 — 1 deposited under accession number ATCC 98958; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:206; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:206 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:206; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:205. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:205 from nucleotide 571 to nucleotide 891; the nucleotide sequence of SEQ ID NO:205 from nucleotide 745 to nucleotide 891; the nucleotide sequence of the full-length protein coding sequence of clone yk204 — 1 deposited under accession number ATCC 98958; or the nucleotide sequence of a mature protein coding sequence of clone yk204 — 1 deposited under accession number ATCC 98958. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk204 — 1 deposited under accession number ATCC 98958. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:206 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:206, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:206 having biological activity, the fragment comprising the amino acid sequence from amino acid 48 to amino acid 57 of SEQ ID NO:206. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:205. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:205, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:205; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk204 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (j) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:205, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:205; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk204 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:205, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:205 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:205, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:205. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:205 from nucleotide 571 to nucleotide 891, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:205 from nucleotide 571 to nucleotide 891, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:205 from nucleotide 571 to nucleotide 891. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:205 from nucleotide 745 to nucleotide 891, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:205 from nucleotide 745 to nucleotide 891, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:205 from nucleotide 745 to nucleotide 891. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:206; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:206, the fragment comprising eight contiguous amino acids of SEQ ID NO:206; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk204 — 1 deposited under accession number ATCC 98958; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:206. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:206 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:206, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:206 having biological activity, the fragment comprising the amino acid sequence from amino acid 48 to amino acid 57 of SEQ ID NO:206. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:207; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:207 from nucleotide 283 to nucleotide 1560; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk224 — 1 deposited under accession number ATCC 98958; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk224 — 1 deposited under accession number ATCC 98958; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk224 — 1 deposited under accession number ATCC 98958; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk224 — 1 deposited under accession number ATCC 98958;, 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:208; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:208 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:208; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:207. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:207 from nucleotide 283 to nucleotide 1560; the nucleotide sequence of the full-length protein coding sequence of clone yk224 — 1 deposited under accession number ATCC 98958; or the nucleotide sequence of a mature protein coding sequence of clone yk224 — 1 deposited under accession number ATCC 98958. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of done yk224 — 1 deposited under accession number ATCC 98958. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:208 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:208, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:208 having biological activity, the fragment comprising the amino acid sequence from amino acid 208 to amino acid 217 of SEQ ID NO:208. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:207. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:207, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:207; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk224 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:207, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:207; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk224 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:207, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:207 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:207, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:207. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:207 from nucleotide 283 to nucleotide 1560, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:207 from nucleotide 283 to nucleotide 1560, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:207 from nucleotide 283 to nucleotide 1560. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:208; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:208, the fragment comprising eight contiguous amino acids of SEQ ID NO:208; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk224 — 1 deposited under accession number ATCC 98958; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:208. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:208 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:208, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:208 having biological activity, the fragment comprising the amino acid sequence from amino acid 208 to amino acid 217 of SEQ ID NO:208. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:209; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:209 from nucleotide 485 to nucleotide 1465; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:209 from nucleotide 560 to nucleotide 1465; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone yk261 — 1 deposited under accession number ATCC 98958; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone yk261 — 1 deposited under accession number ATCC 98958; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone yk261 — 1 deposited under accession number ATCC 98958; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone yk261 — 1 deposited under accession number ATCC 98958; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:210; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:210 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:210; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:209. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:209 from nucleotide 485 to nucleotide 1465; the nucleotide sequence of SEQ ID NO:209 from nucleotide 560 to nucleotide 1465; the nucleotide sequence of the full-length protein coding sequence of clone yk261 — 1 deposited under accession number ATCC 98958; or the nucleotide sequence of a mature protein coding sequence of clone yk261 — 1 deposited under accession number ATCC 98958. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone yk261 — 1 deposited under accession number ATCC 98958. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:210 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:210, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:210 having biological activity, the fragment comprising the amino acid sequence from amino acid 158 to amino acid 167 of SEQ ID NO:210. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:209. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:209, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:209; and 
     (ab) the nucleotide sequence of the cDNA insert of clone yk261 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:209, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:209; and 
     (bb) the nucleotide sequence of the cDNA insert of clone yk261 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:209, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:209 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:209, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:209. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:209 from nucleotide 485 to nucleotide 1465, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:209 from nucleotide 485 to nucleotide 1465, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:209 from nucleotide 485 to nucleotide 1465. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:209 from nucleotide 560 to nucleotide 1465, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:209 from nucleotide 560 to nucleotide 1465, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:209 from nucleotide 560 to nucleotide 1465. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:210; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:210, the fragment comprising eight contiguous amino acids of SEQ ID NO:210; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone yk261 — 1 deposited under accession number ATCC 98958; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:210. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:210 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:210, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:210 having biological activity, the fragment comprising the amino acid sequence from amino acid 158 to amino acid 167 of SEQ ID NO:210. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:211; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:211 from nucleotide 96 to nucleotide 821; 
     (c) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ys3 — 1 deposited under accession number ATCC 98958; 
     (d) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ys3 — 1 deposited under accession number ATCC 98958; 
     (e) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ys3 — 1 deposited under accession number ATCC 98958; 
     (f) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ys3 — 1 deposited under accession number ATCC 98958; 
     (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:212; 
     (h) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:212 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:212; 
     (i) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above; 
     (j) a polynucleotide which encodes a species homologue of the protein of (g) or (h) above; 
     (k) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h); and 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(h) and that has a length that is at least 25% of the length of SEQ ID NO:211. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:211 from nucleotide 96 to nucleotide 821; the nucleotide sequence of the full-length protein coding sequence of clone ys3 — 1 deposited under accession number ATCC 98958; or the nucleotide sequence of a mature protein coding sequence of clone ys3 — 1 deposited under accession number ATCC 98958. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ys3 — 1 deposited under accession number ATCC 98958. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:212 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:212, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:212 having biological activity, the fragment comprising the amino acid sequence from amino acid 116 to amino acid 125 of SEQ ID NO:212. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:211. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:211, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:211; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ys3 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:211, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:211; and 
     (bb) the nucleotide sequence of the cDNA insert of clone y53 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:211, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:211 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:211, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:211. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:211 from nucleotide 96 to nucleotide 821, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:211 from nucleotide 96 to nucleotide 821, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:211 from nucleotide 96 to nucleotide 821. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:212; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:212, the fragment comprising eight contiguous amino acids of SEQ ID NO:212; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ys3 — 1 deposited under accession number ATCC 98958; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:212. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:212 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:212, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:212 having biological activity, the fragment comprising the amino acid sequence from amino acid 116 to amino acid 125 of SEQ ID NO:212. 
     In one embodiment, the present invention provides a composition comprising an isolated polynucleotide selected from the group consisting of: 
     (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:213; 
     (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:213 from nucleotide 191 to nucleotide 499; 
     (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:213 from nucleotide 317 to nucleotide 499; 
     (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone ys10 — 1 deposited under accession number ATCC 98958; 
     (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone ys10 — 1 deposited under accession number ATCC 98958; 
     (f) a polynucleotide comprising the nucleotide sequence of a mature protein coding sequence of clone ys10 — 1 deposited under accession number ATCC 98958; 
     (g) a polynucleotide encoding a mature protein encoded by the cDNA insert of clone ys10 — 1 deposited under accession number ATCC 98958; 
     (h) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:214; 
     (i) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:214 having biological activity, the fragment comprising eight contiguous amino acids of SEQ ID NO:214; 
     (j) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(g) above; 
     (k) a polynucleotide which encodes a species homologue of the protein of (h) or (i) above; 
     (l) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i); and 
     (m) a polynucleotide that hybridizes under stringent conditions to any one of the polynucleotides specified in (a)-(i) and that has a length that is at least 25% of the length of SEQ ID NO:213. 
     Preferably, such polynucleotide comprises the nucleotide sequence of SEQ ID NO:213 from nucleotide 191 to nucleotide 499; the nucleotide sequence of SEQ ID NO:213 from nucleotide 317 to nucleotide 499; the nucleotide sequence of the full-length protein coding sequence of clone ys10 — 1 deposited under accession number ATCC 98958; or the nucleotide sequence of a mature protein coding sequence of clone ys10 — 1 deposited under accession number ATCC 98958. In other preferred embodiments, the polynucleotide encodes the full-length or a mature protein encoded by the cDNA insert of clone ys10 — 1 deposited under accession number ATCC 98958. In further preferred embodiments, the present invention provides a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:214 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:214, or a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:214 having biological activity, the fragment comprising the amino acid sequence from amino acid 46 to amino acid 55 of SEQ ID NO:214. 
     Other embodiments provide the gene corresponding to the cDNA sequence of SEQ ID NO:213. 
     Further embodiments of the invention provide isolated polynucleotides produced according to a process selected from the group consisting of: 
     (a) a process comprising the steps of: 
     (i) preparing one or more polynucleotide probes that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (aa) SEQ ID NO:213, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:213; and 
     (ab) the nucleotide sequence of the cDNA insert of clone ys10 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said probe(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; and 
     (iii) isolating the DNA polynucleotides detected with the probe(s); 
     and 
     (b) a process comprising the steps of: 
     (i) preparing one or more polynucleotide primers that hybridize in 6×SSC at 65 degrees C. to a nucleotide sequence selected from the group consisting of: 
     (ba) SEQ ID NO:213, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:213; and 
     (bb) the nucleotide sequence of the cDNA insert of clone ys10 — 1 deposited under accession number ATCC 98958; 
     (ii) hybridizing said primer(s) to human genomic DNA in conditions at least as stringent as 4×SSC at 50 degrees C.; 
     (iii) amplifying human DNA sequences; and 
     (iv) isolating the polynucleotide products of step (b)(iii). 
     Preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:213, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of SEQ ID NO:213 to a nucleotide sequence corresponding to the 3′ end of SEQ ID NO:213, but excluding the poly(A) tail at the 3′ end of SEQ ID NO:213. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:213 from nucleotide 191 to nucleotide 499, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:213 from nucleotide 191 to nucleotide 499, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:213 from nucleotide 191 to nucleotide 499. Also preferably the polynucleotide isolated according to the above process comprises a nucleotide sequence corresponding to the cDNA sequence of SEQ ID NO:213 from nucleotide 317 to nucleotide 499, and extending contiguously from a nucleotide sequence corresponding to the 5′ end of said sequence of SEQ ID NO:213 from nucleotide 317 to nucleotide 499, to a nucleotide sequence corresponding to the 3′ end of said sequence of SEQ ID NO:213 from nucleotide 317 to nucleotide 499. 
     In other embodiments, the present invention provides a composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of: 
     (a) the amino acid sequence of SEQ ID NO:214; 
     (b) a fragment of the amino acid sequence of SEQ ID NO:214, the fragment comprising eight contiguous amino acids of SEQ ID NO:214; and 
     (c) the amino acid sequence encoded by the cDNA insert of clone ys10 — 1 deposited under accession number ATCC 98958; 
     the protein being substantially free from other mammalian proteins. Preferably such protein comprises the amino acid sequence of SEQ ID NO:214. In further preferred embodiments, the present invention provides a protein comprising a fragment of the amino acid sequence of SEQ ID NO:214 having biological activity, the fragment preferably comprising eight (more preferably twenty, most preferably thirty) contiguous amino acids of SEQ ID NO:214, or a protein comprising a fragment of the amino acid sequence of SEQ ID NO:214 having biological activity, the fragment comprising the amino acid sequence from amino acid 46 to amino acid 55 of SEQ ID NO:214. 
     In certain preferred embodiments, the polynucleotide is operably linked to an expression control sequence. The invention also provides a host cell, including bacterial, yeast, insect and mammalian cells, transformed with such polynucleotide compositions. Also provided by the present invention are organisms that have enhanced, reduced, or modified expression of the gene(s) corresponding to the polynucleotide sequences disclosed herein. 
     Processes are also provided for producing a protein, which comprise: 
     (a) growing a culture of the host cell transformed with such polynucleotide compositions in a suitable culture medium; and 
     (b) purifying the protein from the culture. 
     The protein produced according to such methods is also provided by the present invention. 
     Protein compositions of the present invention may further comprise a pharmaceutically acceptable carrier. Compositions comprising an antibody which specifically reacts with such protein are also provided by the present invention. 
     Methods are also provided for preventing, treating or ameliorating a medical condition which comprises administering to a mammalian subject a therapeutically effective amount of a composition comprising a protein of the present invention and a pharmaceutically acceptable carrier. 
    
    
     BRIEF DESCRIPTION OF THE DRAWINGS 
     FIGS. 1A and 1B are schematic representations of the pED6 and pNOTs vectors, respectively, used for deposit of clones disclosed herein. 
    
    
     DETAILED DESCRIPTION 
     ISOLATED PROTEINS AND POLYNUCLEOTIDES 
     Nucleotide and amino acid sequences, as presently determined, are reported below for each clone and protein disclosed in the present application. The nucleotide sequence of each clone can readily be determined by sequencing of the deposited clone in accordance with known methods. The predicted amino acid sequence (both full-length and mature forms) can then be determined from such nucleotide sequence. The amino acid sequence of the protein encoded by a particular clone can also be determined by expression of the clone in a suitable host cell, collecting the protein and determining its sequence. For each disclosed protein applicants have identified what they have determined to be the reading frame best identifiable with sequence information available at the time of filing. 
     As used herein a “secreted” protein is one which, when expressed in a suitable host cell, is transported across or through a membrane, including transport as a result of signal sequences in its amino acid sequence. “Secreted” proteins include without limitation proteins secreted wholly (e.g., soluble proteins) or partially (e.g., receptors) from the cell in which they are expressed. “Secreted” proteins also include without limitation proteins which are transported across the membrane of the endoplasmic reticulum. 
     Clone “ya15 — 1” 
     A polynucleotide of the present invention has been identified as clone “ya15 — 1”. ya15 — 1 was isolated from a human adult testes cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ya15 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ya15 — 1 protein”). 
     The nucleotide sequence of ya15 — 1 as presently determined is reported in SEQ ID NO:1, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ya15 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:2. Amino acids 8 to 20 of SEQ ID NO:2 are a possible leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 21. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the ya15 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ya15 — 1 should be approximately 1100 bp. 
     The nucleotide sequence disclosed herein for ya15 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ya15 — 1 demonstrated at least some similarity with sequences identified as Z94056 (Human DNA sequence from PAC 436M11 on chromosome Xp22.11-22.2; contains a serine threonine protein phosphatase gene, ESTs and STSs). Based upon sequence similarity, ya15 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the ya15 — 1 protein sequence centered around amino acid 40 of SEQ ID NO:2. The nucleotide sequence of ya15 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “ya24 — 1” 
     A polynucleotide of the present invention has been identified as clone “ya24 — 1”. ya24 — 1 was isolated from a human adult testes cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ya24 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ya24 — 1 protein”). 
     The nucleotide sequence of ya24 — 1 as presently determined is reported in SEQ ID NO:3, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ya24 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:4. Amino acids 3 to 15 of SEQ ID NO:4 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 16. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the ya24 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ya24 — 1 should be approximately 750 bp. 
     The nucleotide sequence disclosed herein for ya24 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ya24 — 1 demonstrated at least some similarity with sequences identified as AA537299 (vk46d03.r1 Soares mouse mammary gland NbMMG  Mus musculus  cDNA clone 949637 5′). Based upon sequence similarity, ya24 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Clone “yb42 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb42 — 1”. yb42 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb42 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb42 — 1 protein”). 
     The nucleotide sequence of yb42 — 1 as presently determined is reported in SEQ ID NO:5, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb42 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:6. Amino acids 41 to 53 of SEQ ID NO:6 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 54. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yb42 — 1 protein. 
     Another potential yb42 — 1 reading frame and predicted amino acid sequence is encoded by basepairs 1879 to 2220 of SEQ ID NO:5 and is reported in SEQ ID NO:265; amino acids 54 to 66 of SEQ ID NO:265 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 67 of SEQ ID NO:265. Due to the hydrophobic nature of this predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the protein of SEQ ID NO:265. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb42 — 1 should be approximately 3900 bp. 
     The nucleotide sequence disclosed herein for yb42 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yb42 — 1 demonstrated at least some similarity with sequences identified as AA213992 (zn58d08.s1 Stratagene muscle 937209 Homo sapiens cDNA clone 562383 3′). Based upon sequence similarity, yb42 — 1 proteins and each similar protein or peptide may share at least some activity. The nucleotide sequence of yb42 — 1 indicates that it may contain at least one MIR repeat sequence. 
     Clone “yc9 — 1” 
     A polynucleotide of the present invention has been identified as clone “yc9 — 1”. yc9 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yc9 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yc9 — 1 protein”). 
     The nucleotide sequence of yc9 — 1 as presently determined is reported in SEQ ID NO:7, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yc9 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:8. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yc9 — 1 should be approximately 3300 bp. 
     The nucleotide sequence disclosed herein for yc9 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yc9 — 1 demonstrated at least some similarity with sequences identified as AA588539 (nm94a07.s1 NCI_CGAP_Co9 Homo sapiens cDNA clone IMAGE:1075860) and N47418 (yy88e12.r1 Homo sapiens cDNA clone 280654 5′). The predicted amino acid sequence disclosed herein for yc9 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yc9 — 1 protein demonstrated at least some similarity to sequences identified as X97196 ( D. melanogaster  X gene). Based upon sequence similarity, yc9 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the yc9 — 1 protein sequence, centered around amino acids 80 and 200 of SEQ ID NO:8, respectively. 
     Clone “yc19 — 1” 
     A polynucleotide of the present invention has been identified as clone “yc19 — 1”. yc19 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yc19 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yc19 — 1 protein”). 
     The nucleotide sequence of yc19 — 1 as presently determined is reported in SEQ ID NO:9, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yc19 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:10. Amino acids 106 to 118 of SEQ ID NO:10 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 119. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yc19 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yc19 — 1 should be approximately 1400 bp. 
     The nucleotide sequence disclosed herein for yc19 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yc19 — 1 demonstrated at least some similarity with sequences identified as AA126002 (zl85a08.s1 Stratagene colon (#937204) Homo sapiens cDNA clone 511382 3′) and AA307000 (EST177917 Colon carcinoma (HCC) cell line  Homo sapiens  cDNA 5′ end). The predicted amino acid sequence disclosed herein for yc19 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yc19 — 1 protein demonstrated at least some similarity to sequences identified as X83742 (MAP kinase phosphotase [ Xenopus laevis ]), and to several tyrosine phosphatases from other species. Based upon sequence similarity, yc19 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domain within the yc19 — 1 protein sequence centered around amino acid 43 of SEQ ID NO:10; this region (amino acids 30 to 42 of SEQ ID NO:10) may also be a leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 43. 
     yc19 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 23 kDa was detected in conditioned medium and membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “yc20 — 1” 
     A polynucleotide of the present invention has been identified as clone “yc20 — 1”. yc20 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yc20 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yc20 — 1 protein”). 
     The nucleotide sequence of yc20 — 1 as presently determined is reported in SEQ ID NO:11, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yc20 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:12. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yc20 — 1 should be approximately 1450 bp. 
     The nucleotide sequence disclosed herein for yc20 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yc20 — 1 demonstrated at least some similarity with sequences identified as AA447839 (aa18c12.r1 Soares NhHMPu S1  Homo sapiens  cDNA clone 813622 5′), N33405 (yy41e10.s1  Homo sapiens  cDNA clone 273834 3′), and T19519 (Human gene signature HUMGS00580). Based upon sequence similarity, yc20 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Clone “ya9 — 1” 
     A polynucleotide of the present invention has been identified as clone “ya9 — 1”. ya9 — 1 was isolated from a human adult testes cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ya9 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ya9 — 1 protein”). 
     The nucleotide sequence of ya9 — 1 as presently determined is reported in SEQ ID NO:13, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ya9 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:14. Amino acids 15 to 27 of SEQ ID NO:14 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 28. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the ya9 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ya9 — 1 should be approximately 950 bp. 
     The nucleotide sequence disclosed herein for ya9 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ya9 — 1 demonstrated at least some similarity with sequences identified as AA442366 (zv62c04.r1 Soares testis NHT  Homo sapiens  cDNA clone 758214 5′) and AA609166 (af12a08.s1 Soares testis NHT  Homo sapiens  cDNA clone 1031414 3′). Based upon sequence similarity, ya9 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domain within the ya9 — 1 protein sequence, centered around amino acid 62 of SEQ ID NO:14. 
     Clone “ya11 — 1” 
     A polynucleotide of the present invention has been identified as clone “ya11 — 1”. ya11 — 1 was isolated from a human adult testes cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ya11 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ya11 — 1 protein”). 
     The nucleotide sequence of ya11 — 1 as presently determined is reported in SEQ ID NO:15, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ya11 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:16. Amino acids 36 to 48 of SEQ ID NO:16 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 49. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the ya11 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing done ya11 — 1 should be approximately 500 bp. 
     The nucleotide sequence disclosed herein for ya11 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ya11 — 1 demonstrated at least some similarity with sequences identified as Z68274 (Human DNA sequence from cosmid L129H7, Huntington&#39;s Disease Region, chromosome 4p16.3 contains Pseudogene and CpG island). Based upon sequence similarity, ya11 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domain within the ya11 — 1 protein sequence, centered around amino acid 81 of SEQ ID NO:16. 
     Clone “ya28 — 1” 
     A polynucleotide of the present invention has been identified as clone “ya28 — 1”. ya28 — 1 was isolated from a human adult testes cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ya28 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ya28 — 1 protein”). 
     The nucleotide sequence of ya28 — 1 as presently determined is reported in SEQ ID NO:17, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ya28 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:18. Amino acids 41 to 53 of SEQ ID NO:18 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 54. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the ya28 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ya28 — 1 should be approximately 300 bp. 
     The nucleotide sequence disclosed herein for ya28 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ya28 — 1 demonstrated at least some similarity with sequences identified as AA576255 (nm62b09.s1 NCI_CGAP_Br3  Homo sapiens  cDNA clone IMAGE:1072793). Based upon sequence similarity, ya28 — 1 proteins and each similar protein or peptide may share at least some activity. 
     ya28 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 23 kDa was detected in membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “yb81 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb81 — 1”. yb81 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb81 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb81 — 1 protein”). 
     The nucleotide sequence of yb81 — 1 as presently determined is reported in SEQ ID NO:19, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb81 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:20. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb81 — 1 should be approximately 1200 bp. 
     The nucleotide sequence disclosed herein for yb81 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yb81 — 1 demonstrated at least some similarity with sequences identified as T67164 (Human alpha-N-acetylglucosaminidase gene). Based upon sequence similarity, yb81 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the yb81 — 1 protein sequence centered around amino acid 73 of SEQ ID NO:20. 
     Clone “yc14 — 1” 
     A polynucleotide of the present invention has been identified as clone “yc14 — 1”. yc14 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yc14 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yc14 — 1 protein”). 
     The nucleotide sequence of yc14 — 1 as presently determined is reported in SEQ ID NO:21, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yc14 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:22. Amino acids 388 to 400 of SEQ ID NO:22 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 401. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yc14 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yc14 — 1 should be approximately 3000 bp. 
     The nucleotide sequence disclosed herein for yc14 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yc14 — 1 demonstrated at least some similarity with sequences identified as AA007392 (zh99a08.r1 Soares fetal liver spleen 1NFLS S1  Homo sapiens  cDNA clone 429398 5′), AA573120 (nj41e10.s1 NCI_CGAP_AA1  Homo sapiens  cDNA clone IMAGE 995082 similar to TR G285999 G285999 ORF, COMPLETE CDS), and D13642 (Human mRNA for KIAA0017 gene, complete cds). The predicted amino acid sequence disclosed herein for yc14 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yc14 — 1 protein demonstrated at least some similarity to sequences identified as D13642 (KIAA0017  [Homo sapiens ]) and Z47816 (unknown [ Saccharomyces cerevisiae ] ( S. cerevisiae  chromosome M cosmid 9827, and translated products)). The yc14 — 1 protein contains the immunoglobulin and major histocompatibility complex protein signature at its extreme N-terminus (starting at amino acid 3 of SEQ ID NO:22). Based upon sequence similarity, yc14 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts four additional potential transmembrane domains within the yc14 — 1 protein sequence, centered around amino acids 50, 200, 210, and 830 of SEQ ID NO:22, respectively. 
     yc14 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 92 kDa was detected in membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “yc24 — 1” 
     A polynucleotide of the present invention has been identified as clone “yc24 — 1”. yc24 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yc24 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yc24 — 1 protein”). 
     The nucleotide sequence of yc24 — 1 as presently determined is reported in SEQ ID NO:23, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yc24 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:24. Amino acids 50 to 62 of SEQ ID NO:24 are a possible leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 63. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yc24 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yc24 — 1 should be approximately 1650 bp. 
     The nucleotide sequence disclosed herein for yc24 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yc24 — 1 demonstrated at least some similarity with sequences identified as AA172170 (zp29b07.s1 Stratagene neuroepithellum (#937231)  Homo sapiens  cDNA clone 610837 3′ similar to gb L10240 BASIGIN PRECURSOR (HUMAN), AA756004 (vv37a04.r1 Stratagene mouse heart (#937316)  Mus musculus  cDNA clone 1224558 5′ similar to TR:Q14134 Q14134 ATAXIA-TELANGIECTASIA GROUP D-ASSOCIATED PROTEIN, mRNA sequence), D48379 (Rice cDNA, partial sequence (S145461A), mRNA sequence), E07941 (cDNA encoding human basigin1), L20471 (Human extracellular matrix metalloproteinase inducer gene, complete cds), Q71341 (Human basigin I immunoglobulin gene), and X64364 ( H.sapiens  mRNA for M6 antigen). The M6 antigen has been localized in all leucocyte lines examined (including lymphocytes, monocytes, and granulocytes) and is implicated in interacting with cytokine factors like GM-CSF and interferon gamma. A protein that is at least very similar to M6 antigen, extracellular matrix metalloproteinase inducer (EMMPRIN), has been localized to the surface of tumor cells and is implicated in stimulating several matrix metalloproteinases in the fibroblasts. Based upon sequence similarity, yc24 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the yc24 — 1 protein sequence near the N-terminus of SEQ ID NO:24. 
     Clone “yc25 — 1” 
     A polynucleotide of the present invention has been identified as clone “yc25 — 1”. yc25 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yc25 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yc25 — 1 protein”). 
     The nucleotide sequence of yc25 — 1 as presently determined is reported in SEQ ID NO:25, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yc25 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:26. Amino acids 6 to 18 of SEQ ID NO:26 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 19. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yc25 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yc25 — 1 should be approximately 1800 bp. 
     The nucleotide sequence disclosed herein for yc25 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yc25 — 1 demonstrated at least some similarity with sequences identified as AA332406 (EST36341 Embryo, 8 week I  Homo sapiens  cDNA 5′ end), T20094 (Human gene signature HUMGS01237), and W73912 (zd71a11.s1 Soares fetal heart NbHH19W  Homo sapiens  cDNA clone 346076 3′). Based upon sequence similarity, yc25 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Clone “ye2 — 1” 
     A polynucleotide of the present invention has been identified as clone “ye2 — 1”. ye2 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ye2 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ye2 — 1 protein”). 
     The nucleotide sequence of ye2 — 1 as presently determined is reported in SEQ ID NO:27, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ye2 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:28. Amino acids 30 to 42 of SEQ ID NO:28 are a possible leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 43. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the ye2 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ye2 — 1 should be approximately 1500 bp. 
     The nucleotide sequence disclosed herein for ye2 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ye2 — 1 demonstrated at least some similarity with sequences identified as AA354797 (EST63132 Jurkat T-cells V  Homo sapiens  cDNA 5′ end) and Z43858 ( H. sapiens  partial cDNA sequence; clone c-1md12). Based upon sequence similarity, ye2 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domain within the ye2 — 1 protein sequence centered around amino acid 70 of SEQ ID NO:28. 
     Clone “ya65 — 1” 
     A polynucleotide of the present invention has been identified as clone “ya65 — 1”. ya65 — 1 was isolated from a human adult testes cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ya65 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ya65 — 1 protein”). 
     The nucleotide sequence of ya65 — 1 as presently determined is reported in SEQ ID NO:29, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ya65 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:30. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ya65 — 1 should be approximately 550 bp. 
     The nucleotide sequence disclosed herein for ya65 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ya65 — 1 demonstrated at least some similarity with sequences identified as AI005084 (ou08g10.x1 Soares_NFL_T_GBC_S1  Homo sapiens  cDNA clone IMAGE:1625730 3′, mRNA sequence). Based upon sequence similarity, ya65 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the ya65 — 1 protein sequence centered around amino acid 87 of SEQ ID NO:30. 
     Clone “yb60 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb60 — 1”. yb60 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb60 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb60 — 1 protein”). 
     The nucleotide sequence of yb60 — 1 as presently determined is reported in SEQ ID NO:31, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb60 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:32. Amino acids 46 to 58 of SEQ ID NO:32 are a possible leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 59. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yb60 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb60 — 1 should be approximately 2500 bp. 
     The nucleotide sequence disclosed herein for yb60 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yb60 — 1 demonstrated at least some similarity with sequences identified as AA505869 (nh99f02.s1 NCI_CGAP_Br2  Homo sapiens  cDNA clone IMAGE:966651), H29487 (ym60a10.r1  Homo sapiens  cDNA clone 52621 5′), and T24510 (Human gene signature HUMGS06552; standard; cDNA to mRNA). Based upon sequence similarity, yb60 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Clone “yb139 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb139 — 1”. yb139 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb139 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb139 — 1 protein”). 
     The nucleotide sequence of yb139 — 1 as presently determined is reported in SEQ ID NO:33, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb139 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:34. Amino acids 101 to 113 of SEQ ID NO:34 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 114. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yb139 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb139 — 1 should be approximately 1000 bp. 
     The nucleotide sequence disclosed herein for yb139 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yb139 — 1 demonstrated at least some similarity with sequences identified as AA332206 (EST36115 Embryo, 8 week I  Homo sapiens  cDNA 5′ end, mRNA sequence). Based upon sequence similarity, yb139 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domain within the yb139 — 1 protein sequence centered around amino acid 42 of SEQ ID NO:34. The nucleotide acid sequence of yb139 — 1 indicates that it may contain sequences similar to a primate simple repeat and to the  M. serrator  retropseudogene-like repetitive element I. 
     Clone “yc29 — 1” 
     A polynucleotide of the present invention has been identified as clone “yc29 — 1”. yc29 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yc29 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yc29 — 1 protein”). 
     The nucleotide sequence of yc29 — 1 as presently determined is reported in SEQ ID NO:35, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yc29 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:36. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yc29 — 1 should be approximately 2100 bp. 
     The nucleotide sequence disclosed herein for yc29 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yc29 — 1 demonstrated at least some similarity with sequences identified as AA195033 (zr35a12.s1 Soares NhHMPu S1  Homo sapiens  cDNA clone 665374 3′, mRNA sequence), AF046001 ( Homo sapiens  zinc finger transcription factor (ZNF207) mRNA, complete cds), and T23300 (Human gene signature HUMGS05114; standard; cDNA to mRNA). The predicted amino acid sequence disclosed herein for yc29 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yc29 — 1 protein demonstrated at least some similarity to the sequence identified as AF046001 (zinc finger transcription factor [ Homo sapiens ]). The presence of zinc fingers in a protein may indicate that the protein has a DNA-binding function, but zinc fingers may also be protein-protein interaction domains. 
     Based upon sequence similarity, yc29 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the yc29 — 1 protein sequence, one centered around amino acid 175 and another around amino acid 210 of SEQ ID NO:36. 
     yc29 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 56 kDa was detected in membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “yc40 — 1” 
     A polynucleotide of the present invention has been identified as clone “yc40 — 1”. yc40 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yc40 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yc40 — 1 protein”). 
     The nucleotide sequence of yc40 — 1 as presently determined is reported in SEQ ID NO:37, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yc40 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:38. Amino acids 31 to 43 of SEQ ID NO:38 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 44. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yc40 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yc40 — 1 should be approximately 1400 bp. 
     The nucleotide sequence disclosed herein for yc40 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yc40 — 1 demonstrated at least some similarity with sequences identified as D62445 (Human aorta cDNA 5′-end GEN-286A10, mRNA sequence) and T25162 (Human gene signature HUMGS07322; standard; DNA). Based upon sequence similarity, yc40 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the yc40 — 1 protein sequence centered around amino acid 50 of SEQ ID NO:38. 
     Clone “yd10 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd10 — 1”. yd10 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd10 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd10 — 1 protein”). 
     The nucleotide sequence of yd10 — 1 as presently determined is reported in SEQ ID NO:39, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd10 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:40. Amino acids 47 to 59 of SEQ ID NO:40 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 60. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yd10 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd10 — 1 should be approximately 825 bp. 
     The nucleotide sequence disclosed herein for yd10 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd10 — 1 demonstrated at least some similarity with sequences identified as AA587270 (nn70g03.s1 NCI_CGAP_Lar1  Homo sapiens  cDNA clone IMAGE:1089268 similar to contains Alu repetitive element;contains element PTR5 repetitive element; mRNA sequence). Based upon sequence similarity, yd10 — 1 proteins and each similar protein or peptide may share at least some activity. The nucleotide sequence of yd10 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “yf5 — 1” 
     A polynucleotide of the present invention has been identified as clone “yf5 — 1”. yf5 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yf5 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yf5 — 1 protein”). 
     The nucleotide sequence of yf5 — 1 as presently determined is reported in SEQ ID NO:41, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yf5 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:42. Amino acids 9 to 21 of SEQ ID NO:42 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 22. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yf5 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yf5 — 1 should be approximately 1800 bp. 
     The nucleotide sequence disclosed herein for yf5 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yf5 — 1 demonstrated at least some similarity with sequences identified as AA181631 (zp52a03.s1 Stratagene HeLa cell s3 937216  Homo sapiens  cDNA clone 613036 3′, mRNA sequence) and U49082 (Human transporter protein (g17) mRNA, complete cds). The predicted amino acid sequence disclosed herein for yf5 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yf5 — 1 protein demonstrated at least some similarity to the sequence identified as U49082 (transporter protein [ Homo sapiens ]). Based upon sequence similarity, yf5 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts ten additional potential transmembrane domains within the yf5 — 1 protein sequence, centered around amino acids 36, 84, 130, 154, 213, 249, 292, 330, 353, and 389 of SEQ ID NO:42, respectively. The nucleotide sequence of yf5 — 1 indicates that it may contain a MIR repeat region. 
     Clone “ya67 — 1” 
     A polynucleotide of the present invention has been identified as clone “ya67 — 1”. ya67 — 1 was isolated from a human adult testes cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ya67 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ya67 — 1 protein”). 
     The nucleotide sequence of ya67 — 1 as presently determined is reported in SEQ ID NO:43, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ya67 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:44. Amino acids 14 to 26 of SEQ ID NO:44 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 27. Amino acids 16 to 28 are also a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 29. Due to the hydrophobic nature of the predicted leader/signal sequences, each is likely to act as a transmembrane domain should it not be separated from the remainder of the ya67 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ya67 — 1 should be approximately 800 bp. 
     The nucleotide sequence disclosed herein for ya67 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ya67 — 1 demonstrated at least some similarity with sequences identified as AC002042 (*** SEQUENCING IN PROGRESS ***  Homo sapiens  chromosome 16p11.2 BAC clone CIT987SK-A-180G2; HTGS phase 1, 5 unordered pieces). Based upon sequence similarity, ya67 — 1 proteins and each similar protein or peptide may share at least some activity. The nucleotide sequence of ya67 — 1 indicates that it may contain an MIR repeat sequence. 
     ya67 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 21 kDa was detected in membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “ya70 — 1” 
     A polynucleotide of the present invention has been identified as clone “ya70 — 1”. ya70 — 1 was isolated from a human adult testes cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ya70 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ya70 — 1 protein”). 
     The nucleotide sequence of ya70 — 1 as presently determined is reported in SEQ ID NO:45, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ya70 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:46. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ya70 — 1 should be approximately 1500 bp. 
     The nucleotide sequence disclosed herein for ya70 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ya70 — 1 demonstrated at least some similarity with sequences identified as AA813657 (ai69c03.s1 Soares testis NHT  Homo sapiens  cDNA clone 1376068 3′, mRNA sequence) and U84408 (Human IL-1 receptor related protein MyD88 mRNA, complete cds). The predicted amino acid sequence disclosed herein for ya70 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted ya70 — 1 protein demonstrated at least some similarity to the sequences identified as U84408 (MyD88  [Homo sapiens ]). Human MyD88, an IL-6 primary response gene, encodes a protein containing an N-terminal death domain and a C-terminal region that exhibits homology to human IL-1Rp80 and drosophila Toll (IL-1Rp80 and Toll are homologs). Based upon sequence similarity, ya70 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the ya70 — 1 protein sequence, one centered around amino acid 90 and another around amino acid 175 of SEQ ID NO:46. 
     Clone “yb51 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb51 — 1”. yb51 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb51 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb51 — 1 protein”). 
     The nucleotide sequence of yb51 — 1 as presently determined is reported in SEQ ID NO:47, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb51 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:48. Amino acids 5 to 17 of SEQ ID NO:48 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 18. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yb51 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb51 — 1 should be approximately 1400 bp. 
     The nucleotide sequence disclosed herein for yb51 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yb51 — 1 demonstrated at least some similarity with sequences identified as AA058715 (zk70c03.s1 Soares pregnant uterus NbHPU  Homo sapiens  cDNA clone 488164 3′ similar to contains Alu repetitive element; contains element MER1 repetitive element) and Z44795 ( H. sapiens  partial cDNA sequence; clone c-29d08). Based upon sequence similarity, yb51 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domain within the yb51 — 1 protein sequence centered around amino acid 59 of SEQ ID NO:48. The nucleotide sequence of yb51 — 1 indicates that it may contain at least one repetitive element. 
     Clone “yb101 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb101 — 1”. yb101 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb101 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb101 — 1 protein”). 
     The nucleotide sequence of yb101 — 1 as presently determined is reported in SEQ ID NO:49, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb101 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:50. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb101 — 1 should be approximately 1050 bp. 
     The nucleotide sequence disclosed herein for yb101 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yb101 — 1 demonstrated at least some similarity with sequences identified as AC005060 ( Homo sapiens  clone RG086D03; HTGS phase 1, 3 unordered pieces) and D60925 (Human fetal brain cDNA 5′-end GEN-139D01, mRNA sequence). Based upon sequence similarity, yb1011 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the yb101 — 1 protein sequence centered around amino acid 11 of SEQ ID NO:50. 
     yb11 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 8 kDa was detected in membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “yb124 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb124 — 1”. yb124 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb124 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb124 — 1 protein”). 
     The nucleotide sequence of yb124 — 1 as presently determined is reported in SEQ ID NO:51, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb124 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:52. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb124 — 1 should be approximately 1700 bp. 
     The nucleotide sequence disclosed herein for yb124 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yb124 — 1 demonstrated at least some similarity with sequences identified as AA430306 (zw68g03.r1 Soares testis NHT  Homo sapiens  cDNA clone 781396 5′, mRNA sequence). Based upon sequence similarity, yb124 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts three potential transmembrane domains within the yb124 — 1 protein sequence, centered around amino acids 30, 84, and 134 of SEQ ID NO:52, respectively. Amino acids 128 to 140 of SEQ ID NO:52 also have characteristics indicative of a leader/signal sequence. 
     Clone “yb125 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb125 — 1”. yb125 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb125 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb125 — 1 protein”). 
     The nucleotide sequence of yb125 — 1 as presently determined is reported in SEQ ID NO:53, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb125 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:54. Amino acids 15 to 27 of SEQ ID NO:54 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 28. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yb125 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb125 — 1 should be approximately 2000 bp. 
     The nucleotide sequence disclosed herein for yb125 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yb125 — 1 demonstrated at least some similarity with sequences identified as AA340207 (EST45465 Fetal brain m  Homo sapiens  cDNA 5′ end, mRNA sequence) and Q92781 (Human thymopoietin gene fragment; standard; DNA). Based upon sequence similarity, yb125 — 1 proteins and each similar protein or peptide may share at least some activity. The nucleotide sequence of yb125 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “yb179 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb179 — 1”. yb179 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb179 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb179 — 1 protein”). 
     The nucleotide sequence of yb179 — 1 as presently determined is reported in SEQ ID NO:55, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb179 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:56. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb179 — 1 should be approximately 1500 bp. 
     The nucleotide sequence disclosed herein for yb179 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yb179 — 1 demonstrated at least some similarity with sequences identified as AA398428 (zt62a1.s1 Soares testis NHT  Homo sapiens  cDNA clone 726908 3′, mRNA sequence). Based upon sequence similarity, yb179 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the yb179 — 1 protein sequence centered around amino acid 100 of SEQ ID NO:56. Amino acids 97 to 109 of SEQ ID NO:56 are also a possible leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 110. 
     Clone “yc48 — 1” 
     A polynucleotide of the present invention has been identified as clone “yc48 — 1”. yc48 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yc48 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yc48 — 1 protein”). 
     The nucleotide sequence of yc48 — 1 as presently determined is reported in SEQ ID NO:57, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yc48 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:58. Amino acids 5 to 17 of SEQ ID NO:58 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 18. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yc48 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yc48 — 1 should be approximately 1400 bp. 
     The nucleotide sequence disclosed herein for yc48 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yc48 — 1 demonstrated at least some similarity with sequences identified as AI009170 (EST203621 Normalized rat embryo, Bento Soares Rattus sp. cDNA clone REMBJ87 3′ end, mRNA sequence). Based upon sequence similarity, yc48 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two additional potential transmembrane domains within the yc48 — 1 protein sequence, one centered around amino acid 110 and another around amino acid 180 of SEQ ID NO:58. 
     Clone “ye21 — 1” 
     A polynucleotide of the present invention has been identified as clone “ye21 — 1”. ye21 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ye21 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ye21 — 1 protein”). 
     The nucleotide sequence of ye21 — 1 as presently determined is reported in SEQ ID NO:59, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ye21 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:60. Amino acids 9 to 21 of SEQ ID NO:60 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 22. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the ye21 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ye21 — 1 should be approximately 1550 bp. 
     The nucleotide sequence disclosed herein for ye21 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. No significant hits were found in the databases. The TopPredII computer program predicts a potential transmembrane domain within the ye21 — 1 protein sequence centered around amino acid 66 of SEQ ID NO:60. The nucleotide sequence of ye21 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “ye22 — 1” 
     A polynucleotide of the present invention has been identified as clone “ye22 — 1”. ye22 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ye22 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ye22 — 1 protein”). 
     The nucleotide sequence of ye22 — 1 as presently determined is reported in SEQ ID NO:61, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ye22 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:62. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ye22 — 1 should be approximately 1600 bp. 
     The nucleotide sequence disclosed herein for ye22 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ye22 — 1 demonstrated at least some similarity with sequences identified as AJ002553 (*** SEQUENCING IN PROGRESS ***  Homo sapiens  genomic DNA (PAC 1118i22) from chromosome 11; HTGS phase 1) and T19813 (Human gene signature HUMGS00891; standard; cDNA to mRNA). The predicted amino acid sequence disclosed herein for ye22 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted ye22 — 1 protein demonstrated at least some similarity to the sequence identified as AF003145 (No definition line found [ Caenorhabditis elegans ]). Based upon sequence similarity, ye22 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the ye22 — 1 protein sequence centered around amino acid 77 of SEQ ID NO:62. The nucleotide sequence of ye22 — 1 indicates that it may contain repetitive elements. 
     Clone “ye39 — 1” 
     A polynucleotide of the present invention has been identified as clone “ye39 — 1”. ye39 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ye39 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ye39 — 1 protein”). 
     The nucleotide sequence of ye39 — 1 as presently determined is reported in SEQ ID NO:63, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ye39 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:64. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing done ye39 — 1 should be approximately 1700 bp. 
     The nucleotide sequence disclosed herein for ye39 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ye39 — 1 demonstrated at least some similarity with sequences identified as AA360300 (EST69467 Liver II  Homo sapiens  cDNA 5′ end, mRNA sequence). Based upon sequence similarity, ye39 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the ye39 — 1 protein sequence, one centered around amino acid 20 and another around amino acid 45 of SEQ ID NO:64. 
     Clone “yf9 — 1” 
     A polynucleotide of the present invention has been identified as clone “yf9 — 1”. yf9 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yf9 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yf9 — 1 protein”). 
     The nucleotide sequence of yf9 — 1 as presently determined is reported in SEQ ID NO:65. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yf9 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:66. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yf9 — 1 should be approximately 950 bp. 
     The nucleotide sequence disclosed herein for yf9 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yf9 — 1 demonstrated at least some similarity with sequences identified as AA747796 (nx86a03.s1 NCI_CGAP_GCB1  Homo sapiens  cDNA clone IMAGE 1269100, mRNA sequence) and AF009426 ( Homo sapiens  clone 22 mRNA, alternative splice variant beta-1, complete cds). The predicted amino acid sequence disclosed herein for yf9 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yf9 — 1 protein demonstrated at least some similarity to the sequence identified as AF009426 (clone 22  [Homo sapiens ]). Based upon sequence similarity, yf9 — 1 proteins and each similar protein or peptide may share at least some activity. Clone 22 mRNA was identified from brain transcripts and the corresponding gene has been localized to chromosome 18; the chromosome regions 18p and 18q where the transcripts cluster are candidate regions for bipolar disorder. The protein products of the clone 22 mRNA variants are predicted to be membrane spanning. (Yoshikawa et al., 1997 , Am. J. Med. Genet . 74(2): 140-149, which is incorporated by reference herein). The predicted yf9 — 1 protein appears to be a novel splice variant expressed from the clone 22 gene. The TopPredII computer program predicts a potential transmembrane domain within the yf9 — 1 protein sequence centered around amino acid 39 of SEQ ID NO:66. 
     yf9 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 24 kDa was detected in conditioned medium and membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “yh4 — 1” 
     A polynucleotide of the present invention has been identified as clone “yh4 — 1”. yh4 — 1 was isolated from a human brain (fetal and adult) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yh4 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yh4 — 1 protein”). 
     The nucleotide sequence of yh4 — 1 as presently determined is reported in SEQ ID NO:67, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yh4 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:68. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yh4 — 1 should be approximately 1500 bp. 
     The nucleotide sequence disclosed herein for yh4 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. No significant hits were found in the databases. The TopPredII computer program predicts a potential transmembrane domain within the yh4 — 1 protein sequence centered around amino acid 80 of SEQ ID NO:68. The nucleotide sequence of yh4 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “yi4 — 1” 
     A polynucleotide of the present invention has been identified as clone “yi4 — 1”. yi4 — 1 was isolated from a human brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yi4 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yi4 — 1 protein”). 
     The nucleotide sequence of yi4 — 1 as presently determined is reported in SEQ ID NO:69, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yi4 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:70. Amino acids 18 to 30 of SEQ ID NO:70 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 31. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yi4 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yi4 — 1 should be approximately 1400 bp. 
     The nucleotide sequence disclosed herein for yi4 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yi4 — 1 demonstrated at least some similarity with sequences identified as AA553835 (nk94f03.s1 NCI_CGAP_Co11  Homo sapiens  cDNA clone IMAGE:1028477, mRNA sequence) and T22931 (Human gene signature HUMGS04656; standard; cDNA to mRNA). Based upon sequence similarity, yi4 — 1 proteins and each similar protein or peptide may share at least some activity. The nucleotide sequence of yi4 — 1 indicates that it may contain simple nucleotide repeat sequences. 
     Clone “yj3 — 1” 
     A polynucleotide of the present invention has been identified as clone “yj3 — 1”. yj3 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yj3 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yj3 — 1 protein”). 
     The nucleotide sequence of yj3 — 1 as presently determined is reported in SEQ ID NO:71, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yj3 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:72. Amino acids 8 to 20 of SEQ ID NO:72 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 21. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yj3 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yj3 — 1 should be approximately 900 bp. 
     The nucleotide sequence disclosed herein for yj3 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yj3 — 1 demonstrated at least some similarity with sequences identified as AC004955 ( Homo sapiens  clone DJ1087M19; HTGS phase 1, 7 unordered pieces) and W37665 (zc12f05.r1 Soares parathyroid tumor NbHPA  Homo sapiens  cDNA clone 322113 5′, mRNA sequence). Based upon sequence similarity, yj3 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts four additional potential transmembrane domains within the yj3 — 1 protein sequence, centered around amino acids 17, 45, 87, and 110 of SEQ ID NO:72, respectively. 
     Clone “yj7 — 1” 
     A polynucleotide of the present invention has been identified as clone “yj7 — 1”. yj7 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yj7 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yj7 — 1 protein”). 
     The nucleotide sequence of yj7 — 1 as presently determined is reported in SEQ ID NO:73, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yj7 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:74. Amino acids 21 to 33 of SEQ ID NO:74 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 34. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yj7 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yj7 — 1 should be approximately 1159 bp. 
     The nucleotide sequence disclosed herein for yj7 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yj7 — 1 demonstrated at least some similarity with sequences identified as AA827998 (of10c11.s1 NCI_CGAP_Co12  Homo sapiens  cDNA clone IMAGE:1420724 3′, mRNA sequence), C80074 ( Mus musculus  3.5-dpc blastocyst cDNA 3′-end sequence, mRNA sequence), and T25792 (Human gene signature HUMGS08020; standard; cDNA to mRNA). The predicted amino acid sequence disclosed herein for yj7 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yj7 — 1 protein demonstrated at least some similarity to sequences identified as R61477 (Clavulanic acid dehydrogenase sequence), U43283 (similar to the insect-type alcohol dehydrogenase/ribitol dehydrogenase family [ Caenorhabditis elegans ]), and Z99116 (similar to ketoacyl reductase [ Bacillus subtilus ]). 
     Based upon sequence similarity, yj7 — 1 proteins and each similar protein or peptide may share at least some activity. Motifs search revealed the short-chain alcohol dehydrogenase family signature. These dehydrogenases and reductases are cytoplasmic, however, the amino acid similarity alignment is more consistent with domain/motif sharing. Also, the predicted yj7 — 1 protein demonstrates similarity to proteins that are only “similar to” these dehydrogenase and reductase enzymes; the predicted yj7 — 1 protein exhibits less amino acid similarity to the enzymes themselves. Therefore,the predicted yj7 — 1 protein might be a novel, secreted form of alcohol dehydrogenase. 
     yj7 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 32 kDa was detected in membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “yj10 — 1” 
     A polynucleotide of the present invention has been identified as clone “yj10 — 1”. yj10 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yj10 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yj10 — 1 protein”). 
     The nucleotide sequence of yj10 — 1 as presently determined is reported in SEQ ID NO:75, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yj10 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:76. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yj10 — 1 should be approximately 1600 bp. 
     The nucleotide sequence disclosed herein for yj10 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yj10 — 1 demonstrated at least some similarity with sequences identified as AF072860 ( Homo sapiens  protein activator of the interferon-induced protein kinase (PACT) mRNA, complete cds), AI056368 (oy48c07.x1 NCI_CGAP_Brn23  Homo sapiens  cDNA clone IMAGE 1669068 3′ similar to TR Q91836 Q91836 RNA BINDING PROTEIN; mRNA sequence) and T24520 (Human gene signature HUMGS06564; standard; cDNA to mRNA). The predicted amino acid sequence disclosed herein for yj10 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yj10 — 1 protein demonstrated at least some similarity to the sequence identified as AF072860 (protein activator of the interferon-induced protein kinase [ Homo sapiens ]). Based upon sequence similarity, yj10 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Clone “yj28 — 1” 
     A polynucleotide of the present invention has been identified as clone “yj28 — 1”. yj28 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yj28 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yj28 — 1 protein”). 
     The nucleotide sequence of yj28 — 1 as presently determined is reported in SEQ ID NO:77, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yj28 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:78. Amino acids 160 to 172 of SEQ ID NO:78 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 173. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yj28 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing done yj28 — 1 should be approximately 1250 bp. 
     The nucleotide sequence disclosed herein for yj28 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yj28 — 1 demonstrated at least some similarity with sequences identified as AA402090 (zu53f03.r1 Soares ovary tumor NbHOT  Homo sapiens  cDNA clone 741725 5′, mRNA sequence) and AJ009691 ( Podocoryne carnea  mRNA for SMC2orf protein, partial). The predicted amino acid sequence disclosed herein for yj28 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yj28 — 1 protein demonstrated at least some similarity to the sequence identified as AJ009691 (SMC2orf [ Podocoryne carnea ]). Based upon sequence similarity, yj28 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domain within the yj28 — 1 protein sequence centered around amino acid 348 of SEQ ID NO:78. 
     Clone “yj29 — 1” 
     A polynucleotide of the present invention has been identified as clone “yj29 — 1”. yj29 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yj29 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yj29 — 1 protein”). 
     The nucleotide sequence of yj29 — 1 as presently determined is reported in SEQ ID NO:79, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yj29 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:80. Amino acids 310 to 322 of SEQ ID NO:80 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 323. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yj29 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yj29 — 1 should be approximately 1600 bp. 
     The nucleotide sequence disclosed herein for yj29 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yj29 — 1 demonstrated at least some similarity with sequences identified as AA156900 (zl20c06.r1 Soares pregnant uterus NbHPU  Homo sapiens  cDNA clone 502474 5′ similar to WP:T06D8.8 CE02329; mRNA sequence), AF015416 ( Homo sapiens  chromosome 11 from 11p15.5 region, complete sequence), and T23342 Human gene signature HUMGS05162; standard; cDNA to mRNA). The predicted amino acid sequence disclosed herein for yj29 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yj29 — 1 protein demonstrated at least some similarity to the sequence identified as Z49130 (T06D8.8  [Caenorhabditis elegans ]). Based upon sequence similarity, yj29 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domain within the yj29 — 1 protein sequence centered around amino acid 207 of SEQ ID NO:80. 
     Clone “yj32 — 1” 
     A polynucleotide of the present invention has been identified as clone “yj32 — 1”. yj32 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yj32 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yj32 — 1 protein”). 
     The nucleotide sequence of yj32 — 1 as presently determined is reported in SEQ ID NO:81, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yj32 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:82. Amino acids 64 to 76 of SEQ ID NO:82 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 77. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yj32 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yj32 — 1 should be approximately 1450 bp. 
     The nucleotide sequence disclosed herein for yj32 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. No significant hits were found in the databases. The TopPredII computer program predicts an additional potential transmembrane domain within the yj32 — 1 protein sequence, near the N-terminus of SEQ ID NO:82. The nucleotide sequence of yj32 — 1 indicates that it may contain an Alu repetitive element. yj32 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 10 kDa was detected in conditioned medium using SDS polyacrylamide gel electrophoresis. 
     Clone “yb186 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb186 — 1”. yb186 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb186 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb186 — 1 protein”). 
     The nucleotide sequence of yb186 — 1 as presently determined is reported in SEQ ID NO:83, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb186 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:84. Amino acids 10 to 22 of SEQ ID NO:84 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 23. Amino acids 14 to 26 of SEQ ID NO:84 are also a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning in this case at amino acid 27. Due to the hydrophobic nature of the predicted leader/signal sequences, each is likely to act as a transmembrane domain should it not be separated from the remainder of the yb186 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb186 — 1 should be approximately 2700 bp. 
     The nucleotide sequence disclosed herein for yb186 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yb186 — 1 demonstrated at least some similarity with sequences identified as T25270 (Human gene signature HUMGS07432; standard; cDNA to mRNA) and W73738 (zd50d05.s1 Soares fetal heart NbHH19W  Homo sapiens  cDNA clone 344073 3′, mRNA sequence). Based upon sequence similarity, yb186 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domain within the yb186 — 1 protein sequence centered around amino acid 243 of SEQ ID NO:84. 
     Clone “yb226 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb226 — 1”. yb226 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb226 — 1 is a full-length done, including the entire coding sequence of a secreted protein (also referred to herein as “yb226 — 1 protein”). 
     The nucleotide sequence of yb226 — 1 as presently determined is reported in SEQ ID NO:85, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb226 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:86. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb226 — 1 should be approximately 1800 bp. 
     The nucleotide sequence disclosed herein for yb226 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yb226 — 1 demonstrated at least some similarity with sequences identified as N72056 (yv29f11.r1 Soares fetal liver spleen 1NFLS  Homo sapiens  cDNA clone 244173 5′, mRNA sequence). Based upon sequence similarity, yb226 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the yb226 — 1 protein sequence, one around amino acid 54 and another around amino acid 122 of SEQ ID NO:86. Amino acids 45 to 57 and 77 to 89 of SEQ ID NO:86 are also possible leader/signal sequences, with the predicted mature amino acid sequences beginning at amino acids 58 and 90, respectively. 
     Clone “yd50 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd50 — 1”. yd50 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd50 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd50 — 1 protein”). 
     The nucleotide sequence of yd50 — 1 as presently determined is reported in SEQ ID NO:87, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd50 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:88. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd50 — 1 should be approximately 900 bp. 
     The nucleotide sequence disclosed herein for yd50 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd50 — 1 demonstrated at least some similarity with sequences identified as AA037761 (zk38c07.s1 Soares pregnant uterus NbHPU  Homo sapiens  cDNA clone 485100 3′, mRNA sequence), AA312218 (EST182969 Jurkat T-cells VI  Homo sapiens  cDNA 5′ end, mRNA sequence), and T24178 (Human gene signature HUMGS06183; standard; cDNA to mRNA). The predicted amino acid sequence disclosed herein for yd50 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yd50 — 1 protein demonstrated at least some similarity to sequences identified as AF038613 (undefined protein [ Caenorhabditis elegans ]) and AL023286 (hypothetical protein [ Schizosaccharomyces pombe ]). Based upon sequence similarity, yd50 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the yd50 — 1 protein sequence centered around amino acid 45 of SEQ ID NO:88. 
     Clone “yd51 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd51 — 1”. yd51 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd51 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd51 — 1 protein”). 
     The nucleotide sequence of yd51 — 1 as presently determined is reported in SEQ ID NO:89, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd51 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:90. Amino acids 11 to 23 of SEQ ID NO:90 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 24. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yd51 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd51 — 1 should be approximately 800 bp. 
     The nucleotide sequence disclosed herein for yd51 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd51 — 1 demonstrated at least some similarity with sequences identified as AA205661 (zq68g09.s1 Stratagene neuroepithelium (#937231)  Homo sapiens  cDNA clone 646816 3′, mRNA sequence). Based upon sequence similarity, yd51 — 1 proteins and each similar protein or peptide may share at least some activity. 
     yd51 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 24 kDa was detected in conditioned medium and membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “yd73 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd73 — 1”. yd73 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd73 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd73 — 1 protein”). 
     The nucleotide sequence of yd73 — 1 as presently determined is reported in SEQ ID NO:91, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd73 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:92. Amino acids 67 to 79 of SEQ ID NO:92 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 80. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yd73 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd73 — 1 should be approximately 1000 bp. 
     The nucleotide sequence disclosed herein for yd73 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd73 — 1 demonstrated at least some similarity with sequences identified as AA587100 (nn81g06.s1 NCI_CGAP_Co9  Homo sapiens  cDNA clone IMAGE:1090330, mRNA sequence) and T51192 (Human breast specific gene BSG10 partial cDNA clone HBGDM44; standard; cDNA). The predicted amino acid sequence disclosed herein for yd73 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yd73 — 1 protein demonstrated at least some similarity to the sequence identified as AF000198 (No definition line found (T28F2.2) [ Caenorhabditis elegans ]). Based upon sequence similarity, yd73 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the yd73 — 1 protein sequence, one centered around amino acid 74 and another around amino acid 169 of SEQ ID NO:92. 
     yd73 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 23 kDa was detected in membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “ye43 — 1” 
     A polynucleotide of the present invention has been identified as clone “ye43 — 1”. ye43 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ye43 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ye43 — 1 protein”). 
     The nucleotide sequence of ye43 — 1 as presently determined is reported in SEQ ID NO:93, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ye43 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:94. Amino acids 88 to 100 of SEQ ID NO:94 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 101. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the ye43 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ye43 — 1 should be approximately 1500 bp. 
     The nucleotide sequence disclosed herein for ye43 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ye43 — 1 demonstrated at least some similarity with sequences identified as T23444 (Human gene signature HUMGS05282; standard; cDNA to mRNA) and Z99353 ( Homo sapiens  mRNA; expressed sequence tag; clone DKFZphamy1 — 1a12, 3′ read, mRNA sequence). Based upon sequence similarity, ye43 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the ye43 — 1 protein sequence, one centered around amino acid 51 and another around amino acid 89 of SEQ ID NO:94. 
     Clone “yh71 — 1” 
     A polynucleotide of the present invention has been identified as clone “yh71 — 1”. yh71 — 1 was isolated from a human brain (fetal and adult) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yh71 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yh71 — 1 protein”). 
     The nucleotide sequence of yh71 — 1 as presently determined is reported in SEQ ID NO:95, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yh71 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:96. Amino acids 264 to 276 of SEQ ID NO:96 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 277. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yh71 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yh71 — 1 should be approximately 1891 bp. 
     The nucleotide sequence disclosed herein for yh71 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yh71 — 1 demonstrated at least some similarity with sequences identified as H10493 (yl90h09.r1  Homo sapiens  cDNA clone 45675 5′), T39809 (Mouse H74 gene; standard; DNA), and X85124 ( M.musculus  pacsin gene). Based upon sequence similarity, yh71 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two additional potential transmembrane domains within the yh71 — 1 protein sequence, one centered around amino acid 122 and another around amino acid 190 of SEQ ID NO:96. 
     Clone “yh100 — 1” 
     A polynucleotide of the present invention has been identified as clone “yh100 — 1”. yh100 — 1 was isolated from a human brain (fetal and adult) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yh100 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yh100 — 1 protein”). 
     The nucleotide sequence of yh100 — 1 as presently determined is reported in SEQ ID NO:97, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yh100 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:98. Amino acids 35 to 47 of SEQ ID NO:98 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino add 48. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yh100 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yh100 — 1 should be approximately 2200 bp. 
     The nucleotide sequence disclosed herein for yh100 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. No significant hits were found in the database. The TopPredII computer program predicts an additional potential transmembrane domain within the yh100 — 1 protein sequence, around amino acid 73 of SEQ ID NO:98. The nucleotide sequence of yh100 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “yi3 — 1” 
     A polynucleotide of the present invention has been identified as clone “yi3 — 1”. yi3 — 1 was isolated from a human brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yi3 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yi3 — 1 protein”). 
     The nucleotide sequence of yi3 — 1 as presently determined is reported in SEQ ID NO:99, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yi3 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:100. Amino acids 20 to 32 of SEQ ID NO:100 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 33. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yi3 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yi3 — 1 should be approximately 2000 bp. 
     The nucleotide sequence disclosed herein for yi3 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yi3 — 1 demonstrated at least some similarity with sequences identified as N22677 (yx64a05.s1  Homo sapiens  cDNA clone 266480 3′). Based upon sequence similarity, yi3 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Clone “yj23 — 1” 
     A polynucleotide of the present invention has been identified as clone “yj23 — 1”. yj23 — 1 was isolated from a human fetal kidney (293 cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yj23 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yj23 — 1 protein”). 
     The nucleotide sequence of yj23 — 1 as presently determined is reported in SEQ ID NO:101, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yj23 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:102. Amino acids 12 to 24 of SEQ ID NO:102 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 25. Amino acids 15 to 27 of SEQ ID NO:102 are also a possible leader/signal sequence, with the predicted mature amino acid sequence beginning in this case at amino acid 28, or are a transmembrane domain. Due to the hydrophobic nature of the predicted leader/signal sequences, each is likely to act as a transmembrane domain should it not be separated from the remainder of the yj23 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yj23 — 1 should be approximately 1400 bp. 
     The nucleotide sequence disclosed herein for yj23 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yj23 — 1 demonstrated at least some similarity with sequences identified as A1096483 (qa03c12.x1 NCI_CGAP_Brn23  Homo sapiens  cDNA clone IMAGE:1685686 3′ similar to TR:Q04386 Q04386 HYPOTHETICAL 29.1 KD PROTEIN IN RPII140 5′ REGION; mRNA sequence) and T19036 (Human gene signature HUMGS00043; standard; cDNA to mRNA). Based upon sequence similarity, yj23 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two additional potential transmembrane domains within the yj23 — 1 protein sequence, one centered around amino acid 90 and another around amino acid 199 of SEQ ID NO:102. 
     Clone “yl9 — 1” 
     A polynucleotide of the present invention has been identified as clone “yl9 — 1”. yl9 — 1 was isolated from a human adult spleen cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yl9 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yl9 — 1 protein”). 
     The nucleotide sequence of yl9 — 1 as presently determined is reported in SEQ ID NO:103, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yl9 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:104. Amino acids 6 to 18 of SEQ ID NO:104 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 19. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yl9 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yl9 — 1 should be approximately 1100 bp. 
     The nucleotide sequence disclosed herein for yl9 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yl9 — 1 demonstrated at least some similarity with sequences identified as AA902287 (ok69g10.s1 NCI_CGAP_GC4  Homo sapiens  cDNA clone IMAGE 1519266 3′ similar to SW C1QA_HUMAN P02745 COMPLEMENT C1Q SUBCOMPONENT, A CHAIN PRECURSOR; mRNA sequence) and X58861 (Mouse mRNA for complement subcomponent C1Q alpha-chain). The predicted amino acid sequence disclosed herein for yl9 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yl9 — 1 protein demonstrated at least some similarity to sequences identified as R22265 (New collagen type protein from chipmunk blood), W09108 (Human adipocyte complement related protein Acrp30), and X58861 (complement subcomponent C1Q A-chain precursor [ Mus musculus ]). Based upon sequence similarity, yl9 — 1 proteins and each similar protein or peptide may share at least some activity. The predicted yl9 — 1 protein has at least some similarity to human, mouse, and rat complement subcomponent C1Q, and motifs and profile hidden markov model analysis of the predicted yl9 — 1 protein have revealed the presence of a C1Q domain signature at amino acids 116 to 241 of SEQ ID NO:104. C1Q is a subunit of the C1 enzyme complex that activates the serum complement system. The collagen-like regions of C1Q interact with the Ca(2+)-Dependent C1R(2)/C1S(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1Q with the Fc regions of IgG or IgM antibody present in immune complexes. The C1Q domain has been found in the C-terminus of vertebrate secreted or membrane-bound proteins which are mostly short-chain collagens and collagen-like molecules. The predicted yl9 — 1 protein appears to encode a novel member of the C1 enzyme complex, having the highest degree of similarity to the A-chain of the complex. The TopPredII computer program predicts a potential transmembrane domain within the yl9 — 1 protein sequence centered around amino acid 160 of SEQ ID NO:104. 
     yl9 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 23 kDa was detected in membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “ya66 — 1” 
     A polynucleotide of the present invention has been identified as clone “ya66 — 1”. ya66 — 1 was isolated from a human adult testes cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ya66 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ya66 — 1 protein”). 
     The nucleotide sequence of ya66 — 1 as presently determined is reported in SEQ ID NO:105, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ya66 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:106. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ya66 — 1 should be approximately 1050 bp. 
     The nucleotide sequence disclosed herein for ya66 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ya66 — 1 demonstrated at least some similarity with sequences identified as AI096636 (qb57c12.x1 NCI_CGAP_Brn23  Homo sapiens  cDNA clone IMAGE:1704214 3′, mRNA sequence) and T20099 (Human gene signature HUMGS01242; standard; cDNA to mRNA). Based upon sequence similarity, ya66 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the ya66 — 1 protein sequence centered around amino acid 106 of SEQ ID NO:106. 
     Clone “yb187 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb187 — 1”. yb187 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb187 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb187 — 1 protein”). 
     The nucleotide sequence of yb187 — 1 as presently determined is reported in SEQ ID NO:107, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb187 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:108. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb187 — 1 should be approximately 1800 bp. 
     The nucleotide sequence disclosed herein for yb187 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yb187 — 1 demonstrated at least some similarity with sequences identified as AA846805 (aj99f04.s1 Soares parathyroid tumor NbHPA  Homo sapiens  cDNA clone IMAGE:1404607 3′, mRNA sequence) and Q61039 (Human brain Expressed Sequence Tag EST01102; standard; DNA). Based upon sequence similarity, yb187 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the yb187 — 1 protein sequence centered around amino acid 58 of SEQ ID NO:108; amino acids 58 to 70 of SEQ ID NO:108 are also a possible leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 71. 
     Clone “yb219 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb219 — 1”. yb219 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb219 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb219 — 1 protein”). 
     The nucleotide sequence of yb219 — 1 as presently determined is reported in SEQ ID NO:109, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb219 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:110. Amino acids 3 to 15 of SEQ ID NO:110 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 16. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yb219 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb219 — 1 should be approximately 1600 bp. 
     The nucleotide sequence disclosed herein for yb219 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. No significant hits were found in the database. 
     Clone “yb228 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb228 — 1”. yb228 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb228 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb228 — 1 protein”). 
     The nucleotide sequence of yb228 — 1 as presently determined is reported in SEQ ID NO:111, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb228 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:112. Amino acids 1 to 13 of SEQ ID NO:112 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 14. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yb228 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb228 — 1 should be approximately 650 bp. 
     The nucleotide sequence disclosed herein for yb228 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. No hits were found in the database. The TopPredII computer program predicts a potential transmembrane domain within the yb228 — 1 protein sequence centered around amino acid 31 of SEQ ID NO:112. 
     Clone “yc27 — 1” 
     A polynucleotide of the present invention has been identified as clone “yc27 — 1”. yc27 — 1 was isolated from a human fetal kidney (293 embryonal carcinoma cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yc27 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yc27 — 1 protein”). 
     The nucleotide sequence of yc27 — 1 as presently determined is reported in SEQ ID NO:113, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yc27 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:114. Amino acids 111 to 123 of SEQ ID NO:114 are a predicted leader/signal sequence, with the predicted mature amino add sequence beginning at amino add 124. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yc27 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yc27 — 1 should be approximately 1300 bp. 
     The nucleotide sequence disclosed herein for yc27 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yc27 — 1 demonstrated at least some similarity with sequences identified as T23290 (Human gene signature HUMGS05104; standard; cDNA to mRNA) and W60958 (zc98d11.s1 Pancreatic Islet  Homo sapiens  cDNA clone 339189 3′, mRNA sequence). The predicted amino acid sequence disclosed herein for yc27 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yc27 — 1 protein demonstrated at least some similarity to sequences identified as AL021890 (undefined protein [ Arabidopsis thaliana ]) and U00036 (R151.6  [Caenorhabditis elegans ]). Based upon sequence similarity, yc27 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts three potential transmembrane domains within the yc27 — 1 protein sequence, centered around amino acids 68, 107, and 161 of SEQ ID NO:114, respectively. 
     yc27 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 23 kDa was detected in membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “yc49 — 1” 
     A polynucleotide of the present invention has been identified as clone “yc49 — 1”. yc49 — 1 was isolated from a human fetal kidney (293 embryonal carcinoma cell line) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yc49 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yc49 — 1 protein”). 
     The nucleotide sequence of yc49 — 1 as presently determined is reported in SEQ ID NO:115, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yc49 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:116. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yc49 — 1 should be approximately 1000 bp. 
     The nucleotide sequence disclosed herein for yc49 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yc49 — 1 demonstrated at least some similarity with sequences identified as AF052113 ( Homo sapiens  clone 23675 mRNA sequence), N28761 (yx69b12.r1  Homo sapiens  cDNA clone 266975 5′), and T20571 (Human gene signature HUMGS01786; standard; cDNA to mRNA). Based upon sequence similarity, yc49 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the yc49 — 1 protein sequence, one centered around amino acid 48 and another around amino acid 75 of SEQ ID NO:116. Amino acids 38 to 50 of SEQ ID NO:116 are also a possible leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 51. 
     Clone “yd40 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd40 — 1”. yd40 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd40 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd40 — 1 protein”). 
     The nucleotide sequence of yd40 — 1 as presently determined is reported in SEQ ID NO:117, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd40 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:118. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd40 — 1 should be approximately 900 bp. 
     The nucleotide sequence disclosed herein for yd40 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. No significant hits were found in the database. The TopPredII computer program predicts three potential transmembrane domains within the yd40 — 1 protein sequence, centered around amino acids 19, 60, and 86 of SEQ ID NO:118, respectively. The nucleotide sequence of yd40 — 1 indicates that it may contain a MIR repetitive element. 
     Clone “yd64 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd64 — 1”. yd64 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd64 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd64 — 1 protein”). 
     The nucleotide sequence of yd64 — 1 as presently determined is reported in SEQ ID NO:119, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd64 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:120. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd64 — 1 should be approximately 1000 bp. 
     The nucleotide sequence disclosed herein for yd64 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd64 — 1 demonstrated at least some similarity with sequences identified as N59133 (yz62c12.s1 Soares multiple sclerosis 2NbHMSP  Homo sapiens  cDNA clone 287638 3′, mRNA sequence). The predicted amino acid sequence disclosed herein for yd64 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yd64 — 1 protein demonstrated at least some similarity to sequences identified as M98529 (21 kDa protein [ Homo sapiens ]). Based upon sequence similarity, yd64 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domains within the yd64 — 1 protein sequence centered around amino acid 96 of SEQ ID NO:120. 
     yd64 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 23 kDa was detected in conditioned medium using SDS polyacrylamide gel electrophoresis. 
     Clone “ye47 — 1” 
     A polynucleotide of the present invention has been identified as clone “ye47 — 1”. ye47 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ye47 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ye471 protein”). 
     The nucleotide sequence of ye471 as presently determined is reported in SEQ ID NO:121, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ye47 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:122. Amino acids 40 to 52 of SEQ ID NO:122 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 53. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the ye47 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ye47 — 1 should be approximately 1600 bp. 
     The nucleotide sequence disclosed herein for ye47 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ye47 — 1 demonstrated at least some similarity with sequences identified as AC000105 (*** SEQUENCING IN PROGRESS ***  Homo sapiens  Chromosome 22q11.2 MDR Region; HTGS phase 2, 6 ordered pieces). Based upon sequence similarity, ye47 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domain within the ye47 — 1 protein sequence centered around amino acid 42 of SEQ ID NO:122. The nucleotide sequence of ye47 — 1 indicates that it may contain one or more of the following repetitive elements: Alu, MIR. 
     ye47 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 24 kDa was detected in membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “yh50 — 1” 
     A polynucleotide of the present invention has been identified as clone “yh50 — 1”. yh50 — 1 was isolated from a human brain (fetal and adult) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yh50 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yh50 — 1 protein”). 
     The nucleotide sequence of yh50 — 1 as presently determined is reported in SEQ ID NO:123, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yh50 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:124. Amino acids 35 to 47 of SEQ ID NO:124 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 48. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yh50 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yh50 — 1 should be approximately 2515 bp. 
     The nucleotide sequence disclosed herein for yh50 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yh50 — 1 demonstrated at least some similarity with sequences identified as N49425 (yv21c11.r1  Homo sapiens  cDNA clone 243380 5′ similar to contains Alu repetitive element), Q90512 (CEA clone HindIII-Sau3A fragment; standard; DNA), and R98218 (yq75a05.r1  Homo sapiens  cDNA clone 201584 5′ similar to contains Alu repetitive element). Based upon sequence similarity, yh50 — 1 proteins and each similar protein or peptide may share at least some activity. The nucleotide sequence of yh50 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “yh53 — 1” 
     A polynucleotide of the present invention has been identified as clone “yh53 — 1”. yh53 — 1 was isolated from a human brain (fetal and adult) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yh53 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yh53 — 1 protein”). 
     The nucleotide sequence of yh53 — 1 as presently determined is reported in SEQ ID NO:125, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yh53 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:126. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yh53 — 1 should be approximately 1763 bp. 
     The nucleotide sequence disclosed herein for yh53 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yh53 — 1 demonstrated at least some similarity with sequences identified as T23683 (Human gene signature HUMGS05558; standard; cDNA to mRNA) and W52762 (zd13a08.r1 Soares fetal heart NbHH19W  Homo sapiens  cDNA clone 340502 5′, mRNA sequence). Based upon sequence similarity, yh53 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the yh53 — 1 protein sequence centered around amino acid 23 of SEQ ID NO:126. 
     Clone “yh98 — 1” 
     A polynucleotide of the present invention has been identified as clone “yh98 — 1”. yh98 — 1 was isolated from a human brain (fetal and adult) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yh98 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yh98 — 1 protein”). 
     The nucleotide sequence of yh98 — 1 as presently determined is reported in SEQ ID NO:127, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yh98 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:128. Amino acids 24 to 36 of SEQ ID NO:128 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 37. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yh98 — 1 protein. 
     Another potential yh98 — 1 reading frame and predicted amino acid sequence that could be encoded by basepairs 1381 to 1635 of SEQ ID NO:127 is reported in SEQ ID NO:266. Amino acids 64 to 76 of SEQ ID NO:266 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 77. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the protein of SEQ ID NO:266. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yh98 — 1 should be approximately 1000 bp. 
     The nucleotide sequence disclosed herein for yh98 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yh98 — 1 demonstrated at least some similarity with sequences identified as AA187630 (zp73e04.s1 Stratagene HeLa cell s3 937216  Homo sapiens  cDNA clone 625854 3′, mRNA sequence), AA632023 (np74d10.s1 NCI_CGAP_Br2  Homo sapiens  cDNA clone IMAGE:1132051, mRNA sequence), AA837470 (od20e11.s1 NCI_CGAP_GCB1  Homo sapiens  cDNA clone IMAGE:1368524, mRNA sequence), AF034176 ( Homo sapiens  ntcon5 contig mRNA, partial sequence, mRNA sequence), AF052101 ( Homo sapiens  clone 23872 mRNA sequence), AI092946 (qa81c03.x1 Soares_fetal_heart_NbHH19W  Homo sapiens  cDNA clone IMAGE:1693156 3′, mRNA sequence), and Q76621 (Human genome fragment (Preferred); standard; DNA). Based upon sequence similarity, yh98 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Clone “ya69 — 1” 
     A polynucleotide of the present invention has been identified as clone “ya69 — 1”. ya69 — 1 was isolated from a human adult testes cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ya69 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ya69 — 1 protein”). 
     The nucleotide sequence of ya69 — 1 as presently determined is reported in SEQ ID NO:129, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ya69 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:130. Amino acids 35 to 47 of SEQ ID NO:130 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 48. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the ya69 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ya69 — 1 should be approximately 2000 bp. 
     The nucleotide sequence disclosed herein for ya69 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ya69 — 1 demonstrated at least some similarity with sequences identified as A1075196 (oy96c08.x1 Soares_fetal_liver_spleen — 1NFLS_S1  Homo sapiens  cDNA clone IMAGE:1673678 3′, mRNA sequence). Based upon sequence similarity, ya69 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the ya69 — 1 protein sequence, centered around amino acid 40 of SEQ ID NO:130. 
     Clone “yd107 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd107 — 1”. yd107 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd107 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd107 — 1 protein”). 
     The nucleotide sequence of yd107 — 1 as presently determined is reported in SEQ ID NO:131, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd107 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:132. Amino acids 37 to 49 of SEQ ID NO:132 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 50. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yd107 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd107 — 1 should be approximately 1000 bp. 
     The nucleotide sequence disclosed herein for yd107 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd107 — 1 demonstrated at least some similarity with sequences identified as AA910935 (ok85f02.s1 NCI_CGAP_Kid3  Homo sapiens  cDNA clone IMAGE:1520763 3′ similar to WP:R05D11.5 CE06240; mRNA sequence) and T26576 (Human gene signature HUMGS08822; standard; cDNA to mRNA). The predicted amino acid sequence disclosed herein for yd107 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yd107 — 1 protein demonstrated at least some similarity to sequences identified as Z75546 (R05D11.5  [Caenorhabditis elegans ]). Based upon sequence similarity, yd107 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the yd107 — 1 protein sequence, one centered around amino acid 48 and another around amino acid 121 of SEQ ID NO:132. 
     Clone “yd145 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd145 — 1”. yd145 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd145 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd145 — 1 protein”). 
     The nucleotide sequence of yd145 — 1 as presently determined is reported in SEQ ID NO:133, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd145 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:134. Amino acids 3 to 15 of SEQ ID NO:134 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 16. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yd145 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd145 — 1 should be approximately 750 bp. 
     The nucleotide sequence disclosed herein for yd145 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd145 — 1 demonstrated at least some similarity with sequences identified as AA432034 (zw80e01.r1 Soares testis NHT  Homo sapiens  cDNA clone 782520 5′, mRNA sequence) and X87489 ( H.sapiens  genomic DNA (chromosome 3; clone NL1243D)). Based upon sequence similarity, yd145 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domain within the yd145 — 1 protein sequence centered around amino acid 45 of SEQ ID NO:134. 
     Clone “yh24 — 1” 
     A polynucleotide of the present invention has been identified as clone “yh24 — 1”. yh24 — 1 was isolated from a human brain (fetal and adult) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yh24 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yh24 — 1 protein”). 
     The nucleotide sequence of yh24 — 1 as presently determined is reported in SEQ ID NO:135, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yh24 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:136. Another potential yh24 — 1 reading frame and predicted amino acid sequence that could be encoded by basepairs 676 to 939 of SEQ ID NO:135 is reported in SEQ ID NO:267. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing done yh24 — 1 should be approximately 1000 bp. 
     The nucleotide sequence disclosed herein for yh24 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yh24 — 1 demonstrated at least some similarity with sequences identified as AA129061 (zo11f12.r1 Stratagene neuroepithelium NT2RAMI 937234  Homo sapiens  cDNA clone 567407 5′ similar to TR:G439877 G439877 REVERSE TRANSCRIPTASE; mRNA sequence). Based upon sequence similarity, yh24 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the yh24 — 1 protein sequence of SEQ ID NO:136, one centered around amino acid 52 and another near the N-terminus of SEQ ID NO:136, the latter domain also being a possible signal/leader sequence. Analysis of the possible yh24 — 1 amino acid sequence of SEQ ID NO:267 reveals a binding-protein-dependent transport systems inner membrane component signature. This signature is present in the integral inner-membrane proteins superfamily which translocate substrates across the membrane. 
     Clone “yi11 — 1” 
     A polynucleotide of the present invention has been identified as clone “yi11 — 1”. yi11 — 1 was isolated from a human brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yi11 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yi11 — 1 protein”). 
     The nucleotide sequence of yi11 — 1 as presently determined is reported in SEQ ID NO:137, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino add sequence of the yi11 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:138. Amino acids 128 to 140 of SEQ ID NO:138 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 141. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yi11 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yi11 — 1 should be approximately 1550 bp. 
     The nucleotide sequence disclosed herein for yi11 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yi11 — 1 demonstrated at least some similarity with sequences identified as AA772340 (ai43c02.s1 Soares parathyroid tumor NbHPA  Homo sapiens  cDNA clone 1359746 3′, mRNA sequence), T26648 (Human gene signature HUMGS08895; standard; cDNA to mRNA), and U48972 ( Mus musculus  spindlin (Spin) mRNA, complete cds). Based upon sequence similarity, yi11 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts four potential transmembrane domains within the yi11 — 1 protein sequence, centered around amino acids 20, 45, 90, and 136 of SEQ ID NO:138, respectively, with the most N-terminal domain also being a possible signal/leader sequence. 
     Clone “yi18 — 1” 
     A polynucleotide of the present invention has been identified as clone “yi18 — 1”. yi18 — 1 was isolated from a human brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yi18 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yi18 — 1 protein”). 
     The nucleotide sequence of yi18 — 1 as presently determined is reported in SEQ ID NO:139, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yi18 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:140. Amino acids 48 to 60 of SEQ ID NO:140 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 61. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yi18 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yi18 — 1 should be approximately 1850 bp. 
     The nucleotide sequence disclosed herein for yi18 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yi18 — 1 demonstrated at least some similarity with sequences identified as AC003086 Human BAC clone RG104F04 from 7q21-q22, complete sequence), T81349 (yd27c10.s1  Homo sapiens  cDNA clone 109458 3′), and T81524 (yd27c10.r1  Homo sapiens  cDNA clone 109458 5′). Based upon sequence similarity, yi18 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Clone “yk14 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk14 — 1”. yk14 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk14 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk14 — 1 protein”). 
     The nucleotide sequence of yk14 — 1 as presently determined is reported in SEQ ID NO:141, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk14 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:142. Amino acids 17 to 29 of SEQ ID NO:142 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 30. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yk14 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk14 — 1 should be approximately 1067 bp. 
     The nucleotide sequence disclosed herein for yk14 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yk14 — 1 demonstrated at least some similarity with sequences identified as AA576618 (nm74f07.s1 NCI_CGAP_Co9  Homo sapiens  cDNA clone IMAGE:1073989, mRNA sequence). Based upon sequence similarity, yk14 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domains within the yk14 — 1 protein sequence centered around amino acid 61 of SEQ ID NO:142. 
     Clone “yk39 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk39 — 1”. yk39 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk39 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk39 — 1 protein”). 
     The nucleotide sequence of yk39 — 1 as presently determined is reported in SEQ ID NO:143, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk39 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:144. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk39 — 1 should be approximately 1300 bp. 
     The nucleotide sequence disclosed herein for yk39 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. No significant hits were found in the database. The TopPredII computer program predicts two potential transmembrane domains within the yk39 — 1 protein sequence, one centered around amino acid 18 and another around amino acid 44 of SEQ ID NO:144. The nucleotide sequence of yk39 — 1 indicates that it may contain a MIR repeat region. 
     Clone “yk91 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk91 — 1”. yk91 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk91 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk91 — 1 protein”). 
     The nucleotide sequence of yk91 — 1 as presently determined is reported in SEQ ID NO:145, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk91 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:146. Amino acids 49 to 61 of SEQ ID NO:146 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 62. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yk91 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk91 — 1 should be approximately 1150 bp. 
     The nucleotide sequence disclosed herein for yk91 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. No significant hits were found in the database. The TopPredII computer program predicts an additional potential transmembrane domain within the yk91 — 1 protein sequence centered around amino acid 80 of SEQ ID NO:146. The nucleotide sequence of yk91 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “yk199 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk199 — 1”. yk199 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk199 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk199 — 1 protein”). 
     The nucleotide sequence of yk199 — 1 as presently determined is reported in SEQ ID NO:147, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk199 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:148. Amino acids 10 to 22 of SEQ ID NO:148 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 23. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yk199 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk199 — 1 should be approximately 1700 bp. 
     The nucleotide sequence disclosed herein for yk199 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yk199 — 1 demonstrated at least some similarity with sequences identified as AI039293 (ox33e12.s1 Soares_total_fetus_Nb2HF8 — 9w  Homo sapiens  cDNA clone IMAGE:1658158 3′, mRNA sequence). Based upon sequence similarity, yk199 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the yk199 — 1 protein sequence, around amino acid 132 of SEQ ID NO:148. The nucleotide sequence and the predicted amino acid sequence of yk199 — 1 indicate that it may contain human TAR1 (telomere-associated repeat 1) sequence. 
     Clone “yl4 — 1” 
     A polynucleotide of the present invention has been identified as clone “yl4 — 1”. yl4 — 1 was isolated from a human adult spleen cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yl4 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yl4 — 1 protein”). 
     The nucleotide sequence of yl4 — 1 as presently determined is reported in SEQ ID NO:149, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yl4 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:150. Amino acids 204 to 216 of SEQ ID NO:150 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 217. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yl4 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yl4 — 1 should be approximately 1250 bp. 
     The nucleotide sequence disclosed herein for yl4 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yl4 — 1 demonstrated at least some similarity with sequences identified as AA283813 (zt19g10.s1 Soares ovary tumor NbHOT  Homo sapiens  cDNA clone 713634 3′, mRNA sequence). Based upon sequence similarity, yl4 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domain within the yl4 — 1 protein sequence centered around amino acid 108 of SEQ ID NO:150. 
     Clone “yl14 — 1” 
     A polynucleotide of the present invention has been identified as clone “yl14 — 1”. yl14 — 1 was isolated from a human adult spleen cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yl14 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yl14 — 1 protein”). 
     The nucleotide sequence of yl14 — 1 as presently determined is reported in SEQ ID NO:151, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yl14 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:152. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yl14 — 1 should be approximately 1000 bp. 
     The nucleotide sequence disclosed herein for yl14 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yl14 — 1 demonstrated at least some similarity with sequences identified as AF034174 ( Homo sapiens  ntcon3 contig mRNA, partial sequence, mRNA sequence) and T03943 (human thrombopoietin genomic coding sequence). Based upon sequence similarity, yl14 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the yl14 — 1 protein sequence, one centered around amino acid 18 and another around amino acid 69 of SEQ ID NO:152; amino acids 61 to 73 are also a possible leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 74 of SEQ ID NO:152. The nucleotide sequence of yl14 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “ya80 — 1” 
     A polynucleotide of the present invention has been identified as clone “ya80 — 1”. ya80 — 1 was isolated from a human adult testes cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ya80 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ya80 — 1 protein”). 
     The nucleotide sequence of ya80 — 1 as presently determined is reported in SEQ ID NO:153, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ya80 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:154. Amino acids 31 to 43 of SEQ ID NO:154 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 44. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the ya80 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ya80 — 1 should be approximately 600 bp. 
     The nucleotide sequence disclosed herein for ya80 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. No significant hits were found in the database. The TopPredII computer program predicts a potential transmembrane domain within the ya80 — 1 protein sequence centered around amino acid 30 of SEQ ID NO:154. 
     Clone “yd61 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd61 — 1”. yd61 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd61 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd61 — 1 protein”). 
     The nucleotide sequence of yd61 — 1 as presently determined is reported in SEQ ID NO:155, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd61 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:156. Amino acids 156 to 168 of SEQ ID NO:156 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 169. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yd61 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd61 — 1 should be approximately 950 bp. 
     The nucleotide sequence disclosed herein for yd61 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd61 — 1 demonstrated at least some similarity with sequences identified as AI017161 (ou28a07.x1 Soares_NFL_T_GBC_S1  Homo sapiens  cDNA clone IMAGE:1627572 3′ similar to TR:Q15040 Q15040 mRNA ;contains TAR1.t1 MSR1 repetitive element; mRNA sequence) and D31884 (Human mRNA for KIAA0063 gene, complete cds). The predicted amino acid sequence disclosed herein for yd61 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yd61 — 1 protein demonstrated at least some similarity to the sequence identified as D31884 (KIAA0063  [Homo sapiens ]). Based upon sequence similarity, yd61 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the yd61 — 1 protein sequence, one centered around amino acid 78 and another around amino acid 11 of SEQ ID NO:156. 
     Clone “yd88 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd88 — 1”. yd88 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd88 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd88 — 1 protein”). 
     The nucleotide sequence of yd88 — 1 as presently determined is reported in SEQ ID NO:157, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd88 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:158. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd88 — 1 should be approximately 1000 bp. 
     The nucleotide sequence disclosed herein for yd88 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd88 — 1 demonstrated at least some similarity with sequences identified as W22362 (66B4 Human retina cDNA Tsp509I-cleaved sublibrary  Homo sapiens  cDNA not directional, mRNA sequence). Based upon sequence similarity, yd88 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domains within the yd88 — 1 protein sequence, around amino acid 60 of SEQ ID NO:158. 
     Clone “yd109 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd109 — 1”. yd109 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd109 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd109 — 1 protein”). 
     The nucleotide sequence of yd109 — 1 as presently determined is reported in SEQ ID NO:159, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd109 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:160. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd109 — 1 should be approximately 550 bp. 
     The nucleotide sequence disclosed herein for yd109 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd109 — 1 demonstrated at least some similarity with sequences identified as AA809139 (nw17h06.s1 NCI_CGAP_GCBO  Homo sapiens  cDNA clone IMAGE:1240763, mRNA sequence) and T21990 (Human gene signature HUMGS03533; standard; cDNA to mRNA). The predicted amino acid sequence disclosed herein for yd109 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yd109 — 1 protein demonstrated at least some similarity to the sequence identified as U80438 (coded for by  C. elegans  cDNA CEESD64F; similar to a short region of DNAJ proteins in part of the DNAJ-like domain [ Caenorhabditis elegans ]). Based upon sequence similarity, yd109 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the yd109 — 1 protein sequence, centered around a position between amino acid 50 and amino acid 54 of SEQ ID NO:160. 
     Clone “yd141 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd141 — 1”. yd141 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd141 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd141 — 1 protein”). 
     The nucleotide sequence of yd141 — 1 as presently determined is reported in SEQ ID NO:161, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd141 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:162. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd141 — 1 should be approximately 650 bp. 
     The nucleotide sequence disclosed herein for yd141 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd141 — 1 demonstrated at least some similarity with sequences identified as AA974564 (op28f05.s1 Soares_NFL_T_GBC_S1  Homo sapiens  cDNA clone IMAGE 1578177 3′, mRNA sequence) and AC004789 ( Homo sapiens  chromosome 16, cosmid clone RT140 (LANL), complete sequence). Based upon sequence similarity, yd141 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts six potential transmembrane domains within the yd141 — 1 protein sequence, one centered around amino acid 46 and others around amino acids 10, 35, 70, 93 and 100 of SEQ ID NO:162, respectively. 
     yd141 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 13 kDa was detected in membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “yd153 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd153 — 1”. yd153 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd153 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd153 — 1 protein”). 
     The nucleotide sequence of yd153 — 1 as presently determined is reported in SEQ ID NO:163, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd153 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:164. Amino acids 18 to 30 of SEQ ID NO:164 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 31. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yd153 — 1 protein. 
     Another potential yd153 — 1 reading frame and predicted amino acid sequence is encoded by basepairs 68 to 244 of SEQ ID NO:163 and is reported in SEQ ID NO:268. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd153 — 1 should be approximately 650 bp. 
     The nucleotide sequence disclosed herein for yd153 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd153 — 1 demonstrated at least some similarity with sequences identified as AA309873 (EST180736 Jurkat T-cells V  Homo sapiens  cDNA 5′ end, mRNA sequence) and T26022 (Human gene signature HUMGS08258; standard; cDNA to mRNA). Based upon sequence similarity, yd153 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Clone “yd165 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd165 — 1”. yd165 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd165 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd165 — 1 protein”). 
     The nucleotide sequence of yd165 — 1 as presently determined is reported in SEQ ID NO:165, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd165 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:166. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd165 — 1 should be approximately 650 bp. 
     The nucleotide sequence disclosed herein for yd165 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd165 — 1 demonstrated at least some similarity with sequences identified as AA873304 (oh75h10.s1 NCI_CGAP_Kid5  Homo sapiens  cDNA clone IMAGE 1472899 3′ similar to SW INI7_HUMAN P40305 INTERFERON-ALPHA INDUCED 11.5 KD PROTEIN; mRNA sequence), V24016 (Human interferon-inducible protein, HIFI, coding sequence; standard; cDNA), and X67325 ( H.sapiens  p27 mRNA). The predicted amino acid sequence disclosed herein for yd165 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yd165 — 1 protein demonstrated at least some similarity to sequences identified as U22970 (interferon-inducible peptide precursor [ Homo sapiens ]), W54040 (Human interferon-inducible protein, HIFI), and X67325 (p27 gene product [ Homo sapiens ]). Based upon sequence similarity, yd165 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts three potential transmembrane domains within the yd165 — 1 protein sequence, centered around amino acids 43, 77, and 107 of SEQ ID NO:166, respectively. 
     Clone “yd178 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd178 — 1”. yd178 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd178 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd178 — 1 protein”). 
     The nucleotide sequence of yd178 — 1 as presently determined is reported in SEQ ID NO:167, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd178 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:168. Amino acids 7 to 19 of SEQ ID NO:168 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 20. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yd178 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd178 — 1 should be approximately 900 bp. 
     The nucleotide sequence disclosed herein for yd178 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd178 — 1 demonstrated at least some similarity with sequences identified as AI141062 (oz43g12.x1 Soares_NhHMPu_S1  Homo sapiens  cDNA clone IMAGE:1678150 3′ similar to SW:LYG_ANSAN P00718 LYSOZYME G; mRNA sequence) and X61002 ( G.gallus  mRNA for goose-type lysozyme). The predicted amino acid sequence disclosed herein for yd178 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yd178 — 1 protein demonstrated at least some similarity to the sequence identified as X61002 (lysozyme [ Gallus gallus ]), and chicken “goose-type” lysozymes. Based upon sequence similarity, yd178 — 1 proteins and each similar protein or peptide may share at least some activity. 
     yd178 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 23 kDa was detected in conditioned medium and membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “yd191 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd191 — 1”. yd191 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd191 — 1 is a full-length done, including the entire coding sequence of a secreted protein (also referred to herein as “yd191 — 1 protein”). 
     The nucleotide sequence of yd191 — 1 as presently determined is reported in SEQ ID NO:169, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd191 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:170. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd191 — 1 should be approximately 550 bp. 
     The nucleotide sequence disclosed herein for yd191 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd191 — 1 demonstrated at least some similarity with sequences identified as H98768 (yx13d09.s1  Homo sapiens  cDNA clone 261617 3′). Based upon sequence similarity, yd191 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the yd191 — 1 protein sequence, one centered around amino acid 55 and another around amino acid 68 of SEQ ID NO:170. 
     Clone “ye7 — 1” 
     A polynucleotide of the present invention has been identified as clone “ye7 — 1”. ye7 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ye7 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ye7 — 1 protein”). 
     The nucleotide sequence of ye7 — 1 as presently determined is reported in SEQ ID NO:171, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ye7 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:172. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ye7 — 1 should be approximately 2400 bp. 
     The nucleotide sequence disclosed herein for ye7 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ye7 — 1 demonstrated at least some similarity with sequences identified as AI017060 (ov01d06.x1 NCI_CGAP_Kid3  Homo sapiens  cDNA clone IMAGE:1636043 3′, mRNA sequence). Based upon sequence similarity, ye7 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two potential transmembrane domains within the ye7 — 1 protein sequence, one centered around amino acid 65 and another around amino acid 105 of SEQ ID NO:172. 
     Clone “yf33 — 1” 
     A polynucleotide of the present invention has been identified as clone “yf33 — 1”. yf33 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yf33 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yf33 — 1 protein”). 
     The nucleotide sequence of yf33 — 1 as presently determined is reported in SEQ ID NO:173, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yf33 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:174. Amino acids 36 to 48 of SEQ ID NO:174 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 49. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yf33 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing done yf33 — 1 should be approximately 2500 bp. 
     The nucleotide sequence disclosed herein for yf33 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. No significant hits were found in the database. The TopPredII computer program predicts a potential transmembrane domain within the yf33 — 1 protein sequence centered around amino acids 93 of SEQ ID NO:174. The nucleotide sequence of yf33 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “yi15 — 1” 
     A polynucleotide of the present invention has been identified as clone “yi15 — 1”. yi15 — 1 was isolated from a human brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yi15 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yi15 — 1 protein”). 
     The nucleotide sequence of yi15 — 1 as presently determined is reported in SEQ ID NO:175, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yi15 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:176. Amino acids 52 to 64 of SEQ ID NO:176 are a possible leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 65. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yi15 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yi15 — 1 should be approximately 2500 bp. 
     The nucleotide sequence disclosed herein for yi15 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yi15 — 1 demonstrated at least some similarity with sequences identified as AA290994 (zs45d07.r1 NCI_CGAP_GCB1  Homo sapiens  cDNA clone IMAGE 700429 5′, mRNA sequence) and AF010235 ( Homo sapiens  mRNA from chromosome 5q31-33 region). Based upon sequence similarity, yi15 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts four potential transmembrane domains within the yi15 — 1 protein sequence, centered around amino adds 30,60,70, and 100 of SEQ ID NO:176, respectively. 
     Clone “yi17 — 1” 
     A polynucleotide of the present invention has been identified as clone “yi17 — 1”. yi17 — 1 was isolated from a human brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yi17 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yi17 — 1 protein”). 
     The nucleotide sequence of yi17 — 1 as presently determined is reported in SEQ ID NO:177, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yi17 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:178. Amino acids 6 to 18 of SEQ ID NO:178 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 19. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yi17 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yi17 — 1 should be approximately 1700 bp. 
     The nucleotide sequence disclosed herein for yi17 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yi17 — 1 demonstrated at least some similarity with sequences identified as AA418852 (zw01f10.s1 Soares NhHMPu S1  Homo sapiens  cDNA clone 768043 3′, mRNA sequence). Based upon sequence similarity, yi17 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Clone “yk38 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk38 — 1”. yk38 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk38 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk38 — 1 protein”). 
     The nucleotide sequence of yk38 — 1 as presently determined is reported in SEQ ID NO:179, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk38 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:180. Amino acids 43 to 55 of SEQ ID NO:180 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 56. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yk38 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk38 — 1 should be approximately 2050 bp. 
     The nucleotide sequence disclosed herein for yk38 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yk38 — 1 demonstrated at least some similarity with sequences identified as AA477698 (zu44c09.r1 Soares ovary tumor NbHOT  Homo sapiens  cDNA clone 740848 5′, mRNA sequence), AF052183 ( Homo sapiens  clone 24804 mRNA sequence), and T26733 (Human gene signature HUMGS08983; standard; cDNA to mRNA). Based upon sequence similarity, yk38 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts four potential transmembrane domains within the yk38 — 1 protein sequence, centered around amino acids 50, 135, 210 and 260 of SEQ ID NO:180, respectively. Hidden markov model and motifs analysis have revealed the presence of two WD-40 (beta transducin/G-beta) repeats at amino acids 118-153 and 157-196 of SEQ ID NO:180. The WD40 domain is thought to mediate protein-protein interactions. 
     Clone “yk51 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk51 — 1”. yk51 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk51 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk51 — 1 protein”). 
     The nucleotide sequence of yk51 — 1 as presently determined is reported in SEQ ID NO:181, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk51 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:182. Amino acids 9 to 21 of SEQ ID NO:182 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 22. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yk51 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk51 — 1 should be approximately 1350 bp. 
     The nucleotide sequence disclosed herein for yk51 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yk51 — 1 demonstrated at least some similarity with sequences identified as Z93014 (Human DNA sequence *** SEQUENCING IN PROGRESS *** from clone 167P19; HTGS phase 1). Based upon sequence similarity, yk51 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two additional potential transmembrane domains within the yk51 — 1 protein sequence, one centered around amino acid 65 and another around amino acid 81 of SEQ ID NO:182. 
     Clone “yk74 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk74 — 1”. yk74 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk74 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk74 — 1 protein”). 
     The nucleotide sequence of yk74 — 1 as presently determined is reported in SEQ ID NO:183, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk74 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:184. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk74 — 1 should be approximately 1500 bp. 
     The nucleotide sequence disclosed herein for yk74 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yk74 — 1 demonstrated at least some similarity with sequences identified as AA910887:(ok87e02.s1 NCI_CGAP_Lu5  Homo sapiens  cDNA clone IMAGE:1520954 3′, mRNA sequence). Based upon sequence similarity, yk74 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts three potential transmembrane domains within the yk74 — 1 protein sequence, centered around amino acids 15, 75, and 105 of SEQ ID NO:184, respectively. The nucleotide sequence of yk74 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “yk89 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk89 — 1”. yk89 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk89 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk89 — 1 protein”). 
     The nucleotide sequence of yk89 — 1 as presently determined is reported in SEQ ID NO:185, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk89 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:186. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk89 — 1 should be approximately 2800 bp. 
     The nucleotide sequence disclosed herein for yk89 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yk89 — 1 demonstrated at least some similarity with sequences identified as AA524431 (ng44e05.s1 NCI_CGAP_Co3  Homo sapiens  cDNA clone IMAGE 937664, mRNA sequence), AF045607 ( Xenopus laevis  origin recognition complex associated protein p81 mRNA, complete cds), U50950 (Human infant brain unknown product mRNA, complete cds), and V23269 (Human latheo protein encoding est cDNA; standard; cDNA). The predicted amino acid sequence disclosed herein for yk89 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yk89 — 1 protein demonstrated at least some similarity to sequences identified as U50950 (unknown [ Homo sapiens ]), W53458 and W53460 (latheo protein [Drosophila]), W53459 (Human latheo protein sequence), and W53461 (Human latheo protein internal reading protein sequence). The latheo gene encodes a protein of ˜70 kD which lacks sequence or domain homology to known proteins. In situ staining with a polyclonal antibody raised against the Latheo protein reveals protein expression in the larval central nervous system (CNS), and specific localization in presynaptic boutons at roughly half the neuromuscular junctions in 3rd-instar larvae, consistent with a role for Latheo protein in synaptic function. (Rohrbough, Pinto, and Tully, Center for Learning and Memory, Cold Spring Harbor Laboratory; and K. S. Broadie, Dept. of Biology, University of Utah, Salt Lake City Utah 84112.) Based upon sequence similarity, yk89 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the yk89 — 1 protein sequence centered around amino acid 250 of SEQ ID NO:186. 
     Clone “yl18 — 1” 
     A polynucleotide of the present invention has been identified as clone “yl18 — 1”. yl18 — 1 was isolated from a human adult spleen cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yl18 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yl18 — 1 protein”). 
     The nucleotide sequence of yl18 — 1 as presently determined is reported in SEQ ID NO:187, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yl18 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:188. Amino acids 13 to of SEQ ID NO:188 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 26. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yl18 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yl18 — 1 should be approximately 3116 bp. 
     The nucleotide sequence disclosed herein for yl18 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yl18 — 1 demonstrated at least some similarity with sequences identified as AA156907 (zl20b04.r1 Soares pregnant uterus NbHPU  Homo sapiens  cDNA clone 502447 5′, mRNA sequence). Based upon sequence similarity, yl18 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts three additional potential transmembrane domains within the yl18 — 1 protein sequence, centered around amino acids 50, 105, and 115 of SEQ ID NO:188. 
     yl18 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 27 kDa was detected in membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “yb325 — 1” 
     A polynucleotide of the present invention has been identified as clone “yb325 — 1”. yb325 — 1 was isolated from a human fetal brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yb325 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yb325 — 1 protein”). 
     The nucleotide sequence of yb325 — 1 as presently determined is reported in SEQ ID NO:189. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yb325 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:190. Amino acids 3 to 15 of SEQ ID NO:190 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 16. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yb325 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yb325 — 1 should be approximately 839 bp. 
     The nucleotide sequence disclosed herein for yb325 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yb325 — 1 demonstrated at least some similarity with sequences identified as AA523268 (ni39g02.s1 NCI_CGAP_Lu1  Homo sapiens  cDNA clone IMAGE: 979250, mRNA sequence). Based upon sequence similarity, yb235 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts an additional potential transmembrane domain within the yb235 — 1 protein sequence, centered around amino acid 90 of SEQ ID NO:188. 
     Clone “yd261 — 1” 
     A polynucleotide of the present invention has been identified as clone “yd261 — 1”. yd261 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yd261 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yd261 — 1 protein”). 
     The nucleotide sequence of yd261 — 1 as presently determined is reported in SEQ ID NO:191, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yd261 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:192. Amino acids 25 to 37 of SEQ ID NO:192 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 38. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yd261 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yd261 — 1 should be approximately 491 bp. 
     The nucleotide sequence disclosed herein for yd261 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yd261 — 1 demonstrated at least some similarity with sequences identified as Q61280 (Human brain Expressed Sequence Tag EST01297; standard; DNA) and T15557 (IB1543 Infant brain, Bento Soares  Homo sapiens  cDNA 3′ end similar to EST01297  H. sapiens  cDNA clone HHCPN24, mRNA sequence). Based upon sequence similarity, yd261 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Clone “yh33 — 1” 
     A polynucleotide of the present invention has been identified as clone “yh33 — 1”. yh33 — 1 was isolated from a human brain (fetal and adult) cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yh33 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yh33 — 1 protein”). 
     The nucleotide sequence of yh33 — 1 as presently determined is reported in SEQ ID NO:193, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yh33 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:194. Amino acids 80 to 92 of SEQ ID NO:194 are a possible leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 93. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yh33 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yh33 — 1 should be approximately 2750 bp. 
     The nucleotide sequence disclosed herein for yh33 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. No significant hits were found in the database. The TopPredII computer program predicts three additional potential transmembrane domains within the yh33 — 1 protein sequence, centered around amino acids 124, 160, and 190 of SEQ ID NO:194, respectively. The nucleotide sequence of yh33 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “yi16 — 1” 
     A polynucleotide of the present invention has been identified as clone “yi16 — 1”. yi16 — 1 was isolated from a human adult brain cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yi16 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yi16 — 1 protein”). 
     The nucleotide sequence of yi16 — 1 as presently determined is reported in SEQ ID NO:195, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yi16 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:196. Amino acids 63 to 75 of SEQ ID NO:196 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 76. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yi16 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yi16 — 1 should be approximately 3000 bp. 
     The nucleotide sequence disclosed herein for yi16 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yi16 — 1 demonstrated at least some similarity with sequences identified as AI076775 (oz31f03.x1 Soares_total_fetus_Nb2HF8 — 9w  Homo sapiens  cDNA clone IMAGE 1676957 3′, mRNA sequence), T19914 (Human gene signature HUMGS01041; standard; cDNA to mRNA), and U79267 (Human clone 23840 mRNA, partial cds). The predicted amino acid sequence disclosed herein for yi16 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yi16 — 1 protein demonstrated at least some similarity to the sequence identified as U79267 (unknown [ Homo sapiens ]). Based upon sequence similarity, yi16 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Clone “yk46 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk46 — 1”. yk46 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk46 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk46 — 1 protein”). 
     The nucleotide sequence of yk46 — 1 as presently determined is reported in SEQ ID NO:197, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk46 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:198. Amino acids 28 to 40 of SEQ ID NO:198 are a possible leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 41. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yk46 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk46 — 1 should be approximately 1900 bp. 
     The nucleotide sequence disclosed herein for yk46 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yk46 — 1 demonstrated at least some similarity with sequences identified as AA203346 (zx56h01.r1 Soares fetal liver spleen 1NFLS S1  Homo sapiens  cDNA clone 446545 5′, mRNA sequence). Based upon sequence similarity, yk46 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two additional potential transmembrane domains within the yk46 — 1 protein sequence, one centered around amino acid 20 and another around amino acid 57 of SEQ ID NO:198. 
     Clone “yk84 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk84 — 1”. yk84 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk84 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk84 — 1 protein”). 
     The nucleotide sequence of yk84 — 1 as presently determined is reported in SEQ ID NO:199, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk84 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:200. Amino acids 36 to 48 of SEQ ID NO:200 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 49. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yk84 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk84 — 1 should be approximately 2400 bp. 
     The nucleotide sequence disclosed herein for yk84 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yk84 — 1 demonstrated at least some similarity with sequences identified as AC004052 ( Homo sapiens  chromosome 4 clone B209B10 map 4q25, complete sequence) and AQ0059417 (CIT-HSP-2348J2.TF CIT-HSP  Homo sapiens  genomic clone 2348J2, genomic survey sequence). Based upon sequence similarity, yk84 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts a potential transmembrane domain within the yk84 — 1 protein sequence, centered around amino acid 49 of SEQ ID NO:200. 
     Clone “yk143 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk143 — 1”. yk143 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk143 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk143 — 1 protein”). 
     The nucleotide sequence of yk143 — 1 as presently determined is reported in SEQ ID NO:201, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk143 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:202. Amino acids 31 to 43 of SEQ ID NO:202 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 44. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yk143 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk143 — 1 should be approximately 1458 bp. 
     The nucleotide sequence disclosed herein for yk143 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yk143 — 1 demonstrated at least some similarity with sequences identified as AA526186 (ni94h03.s1 NCI_CGAP_Pr21  Homo sapiens  cDNA clone IMAGE:984533, mRNA sequence), AB006085 ( Danio rerio  mRNA for MINDIN2, complete cds), and T78360 (Human neuronal attachment factor-1 DNA; standard; DNA). The predicted amino acid sequence disclosed herein for yk143 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yk143 — 1 protein demonstrated at least some similarity to sequences identified as AB006085 (MINDIN2  [Danio rerio ]) and W23663 (Human neuronal attachment factor-1). Human neuronal attachment factor-1 is thought to promote cell-cell interaction and cell adhesion. The predicted yk143 — 1 protein also demonstrated at least some similarity to the extracellular matrix proteins called F- and M-spodins. Based upon sequence similarity, yk143 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two additional potential transmembrane domains within the yk143 — 1 protein sequence, one centered around amino acid 204 and another around amino acid 280 of SEQ ID NO:202. 
     Clone “yk156 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk156 — 1”. yk156 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk156 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk156 — 1 protein”). 
     The nucleotide sequence of yk156 — 1 as presently determined is reported in SEQ ID NO:203, and indudes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk156 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:204. Amino acids 25 to 37 of SEQ ID NO:204 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 38. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yk156 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing done yk156 — 1 should be approximately 1100 bp. 
     The nucleotide sequence disclosed herein for yk156 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yk156 — 1 demonstrated at least some similarity with sequences identified as AC002550 (Human Chromosome 16 BAC clone CIT987SK-A-101F10, complete sequence) and N67878 (yz52b04.s1  Homo sapiens  cDNA clone 286639 3′ similar to gb M29610 GLYCOPHORIN E PRECURSOR (HUMAN)). Based upon sequence similarity, yk156 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Clone “yk204 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk204 — 1”. yk204 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk204 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk204 — 1 protein”). 
     The nucleotide sequence of yk204 — 1 as presently determined is reported in SEQ ID NO:205, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk204 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:206. Amino acids 46 to 58 of SEQ ID NO:206 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 59. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yk204 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk204 — 1 should be approximately 1395 bp. 
     The nucleotide sequence disclosed herein for yk204 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. No significant hits were found in the database. The TopPredII computer program predicts two potential transmembrane domains within the yk204 — 1 protein sequence, one centered around amino acid 59 and another around amino acid 82 of SEQ ID NO:206. The nucleotide sequence of yk204 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “yk224 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk224 — 1”. yk224 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk224 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk224 — 1 protein”). 
     The nucleotide sequence of yk224 — 1 as presently determined is reported in SEQ ID NO:207, and indudes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk224 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:208. Amino acids 13 to 25 of SEQ ID NO:208 are a possible leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 26. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yk224 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk224 — 1 should be approximately 1600 bp. 
     The nucleotide sequence disclosed herein for yk224 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yk224 — 1 demonstrated at least some similarity with sequences identified as AA789332 (aj28h05.s1 Soares testis NHT  Homo sapiens  cDNA clone 1391673 3′ similar to WP:B0410.2 CE06708; mRNA sequence) and AF044208 ( Drosophila melanogaster  Strabismus (stbm) mRNA, complete cds). The predicted amino acid sequence disclosed herein for yk224 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yk224 — 1 protein demonstrated at least some similarity to the sequence identified as AF044208 (Strabismus [ Drosophila melanogaster ]). Strabismus is described as a protein “that regulates tissue polarity and cell fate decisions in Drosophila” (Wolff, T. and Rubin, G. M., 1998 , Development  125(6): 1149-1159, which is incorporated by reference herein). Based upon sequence similarity, yk224 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts four potential transmembrane domains within the yk224 — 1 protein sequence, centered around amino acids 26, 64, 98, and 134 of SEQ ID NO:208, respectively. The nucleotide sequence of yk224 — 1 indicates that it may contain an Alu repetitive element. 
     Clone “yk261 — 1” 
     A polynucleotide of the present invention has been identified as clone “yk261 — 1”. yk261 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. yk261 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “yk261 — 1 protein”). 
     The nucleotide sequence of yk261 — 1 as presently determined is reported in SEQ ID NO:209, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the yk261 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:210. Amino acids 13 to 25 of SEQ ID NO:210 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 26. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the yk261 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone yk261 — 1 should be approximately 2259 bp. 
     The nucleotide sequence disclosed herein for yk261 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. yk261 — 1 demonstrated at least some similarity with sequences identified as AI024733 (ov76e12.x1 Soares_testis_NHT  Homo sapiens  cDNA clone IMAGE:1643278 3′, mRNA sequence). The predicted amino acid sequence disclosed herein for yk261 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted yk261 — 1 protein demonstrated at least some similarity to sequences identified as AF040650 (contains similarity to sodium-potassium-chloride cotransport proteins [ Caenorhabditis elegans ]), AF051561 (similarity to sodium-potassium chloride cotransport proteins [rat]), U13174 (putative basolateral Na-K-2Cl cotransporter [ Mus musculus ]), U55054 (K-Cl cotransporter [ Homo sapiens ]), and Z36104 (similarity to sodium-potassium-chloride cotransport proteins [yeast]). Based upon sequence similarity, yk261 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts two additional potential transmembrane domains within the yk261 — 1 protein sequence, one centered around amino acid 270 and another around amino acid 295 of SEQ ID NO:210. 
     Clone “ys3 — 1” 
     A polynucleotide of the present invention has been identified as clone “ys3 — 1”. ys3 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ys3 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ys3 — 1 protein”). 
     The nucleotide sequence of ys3 — 1 as presently determined is reported in SEQ ID NO:211, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ys3 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:212. Amino acids 112 to 124 of SEQ ID NO:212 are a possible leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 125. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the ys3 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ys3 — 1 should be approximately 1000 bp. 
     The nucleotide sequence disclosed herein for ys3 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ys3 — 1 demonstrated at least some similarity with sequences identified as H93009 (yv07g03.s1  Homo sapiens  cDNA clone 242068 3′). The predicted amino acid sequence disclosed herein for ys3 — 1 was searched against the GenPept and GeneSeq amino acid sequence databases using the BLASTX search protocol. The predicted ys3 — 1 protein demonstrated at least some similarity to sequences identified as L35848 (IgE receptor beta subunit [ Homo sapiens ]) and R42337 (Human FceRI beta). Based upon sequence similarity, ys3 — 1 proteins and each similar protein or peptide may share at least some activity. The TopPredII computer program predicts five potential transmembrane domains within the ys3 — 1 protein sequence, centered around amino acids 60, 90, 125, 190, and 225 of SEQ ID NO:212, respectively. 
     ys3 — 1 protein was expressed in a COS cell expression system, and an expressed protein band of approximately 26 kDa was detected in membrane fractions using SDS polyacrylamide gel electrophoresis. 
     Clone “ys10 — 1” 
     A polynucleotide of the present invention has been identified as clone “ys10 — 1”. ys10 — 1 was isolated from a human adult thymus cDNA library and was identified as encoding a secreted or transmembrane protein on the basis of computer analysis of the amino acid sequence of the encoded protein. ys10 — 1 is a full-length clone, including the entire coding sequence of a secreted protein (also referred to herein as “ys10 — 1 protein”). 
     The nucleotide sequence of ys10 — 1 as presently determined is reported in SEQ ID NO:213, and includes a poly(A) tail. What applicants presently believe to be the proper reading frame and the predicted amino acid sequence of the ys10 — 1 protein corresponding to the foregoing nucleotide sequence is reported in SEQ ID NO:214. Amino acids 30 to 42 of SEQ ID NO:214 are a predicted leader/signal sequence, with the predicted mature amino acid sequence beginning at amino acid 43. Due to the hydrophobic nature of the predicted leader/signal sequence, it is likely to act as a transmembrane domain should the predicted leader/signal sequence not be separated from the remainder of the ys10 — 1 protein. 
     The EcoRI/NotI restriction fragment obtainable from the deposit containing clone ys10 — 1 should be approximately 1079 bp. 
     The nucleotide sequence disclosed herein for ys10 — 1 was searched against the GenBank and GeneSeq nucleotide sequence databases using BLASTN/BLASTX and FASTA search protocols. ys10 — 1 demonstrated at least some similarity with sequences identified as AA436002 (zu03b10.s1 Soares testis NHT  Homo sapiens  cDNA clone 730747 3′, mRNA sequence) and T26591 (Human gene signature HUMGS08837; standard; cDNA to mRNA). Based upon sequence similarity, ys10 — 1 proteins and each similar protein or peptide may share at least some activity. 
     Deposit of Clones 
     Clones ya15 — 1, ya24 — 1, yb42 — 1, yc9 — 1, yc19 — 1, and yc20 — 1 were deposited on Feb. 11, 1998 with the American Type Culture Collection (10801 University Boulevard, Manassas, Va. 20110-2209 U.S.A.) as an original deposit under the Budapest Treaty and were given the accession number ATCC 98650, from which each clone comprising a particular polynucleotide is obtainable. 
     Clones ya9 — 1, ya11 — 1, ya28 — 1, yb81 — 1, and yc14 — 1 were deposited on Apr. 7, 1998 with the American Type Culture Collection (10801 University Boulevard, Manassas, Va. 20110-2209 U.S.A.) as an original deposit under the Budapest Treaty and were given the accession number ATCC 98724, from which each clone comprising a particular polynucleotide is obtainable. 
     Clones yc24 — 1, yc25 — 1, and ye2 — 1 were deposited on May 14, 1998 with the American Type Culture Collection (10801 University Boulevard, Manassas, Va. 20110-2209 U.S.A.) as an original deposit under the Budapest Treaty and were given the accession number ATCC 98755, from which each clone comprising a particular polynucleotide is obtainable. 
     Clones ya65 — 1, yb60 — 1, yb139 — 1, yc29 — 1, yc40 — 1, yd10 — 1, and yf5 — 1 were deposited on Aug. 11, 1998 with the American Type Culture Collection (10801 University Boulevard, Manassas, Va. 20110-2209 U.S.A.) as an original deposit under the Budapest Treaty and were given the accession number ATCC 98834, from which each clone comprising a particular polynucleotide is obtainable. 
     Clones ya67 — 1, ya70 — 1, yb51 — 1, yb101 — 1, yb124 — 1, yb125 — 1, yb179 — 1, yc48 — 1, ye21 — 1, and ye22 — 1 were deposited on Sep. 3, 1998 with the American Type Culture Collection (10801 University Boulevard, Manassas, Va. 20110-2209 U.S.A.) as an original deposit under the Budapest Treaty and were given the accession number ATCC 98864, from which each clone comprising a particular polynucleotide is obtainable. 
     Clones ye39 — 1, yf9 — 1, yh4 — 1, yi4 — 1, yj3 — 1, yj7 — 1, yj10 — 1, yj28 — 1, yj29 — 1, and yj32 — 1 were deposited on Sep. 2, 1998 with the American Type Culture Collection (10801 University Boulevard, Manassas, Va. 20110-2209 U.S.A.) as an original deposit under the Budapest Treaty and were given the accession number ATCC 98861, from which each clone comprising a particular polynucleotide is obtainable. 
     Clones yb186 — 1, yb226 — 1, yd50 — 1, yd51 — 1, yd73 — 1, ye43 — 1, yh71 — 1, yj100 — 1, yi3 — 1, yj23 — 1, and yl9 — 1 were deposited on Sep. 10, 1998 with the American Type Culture Collection (10801 University Boulevard, Manassas, Va. 20110-2209 U.S.A.) as an original deposit under the Budapest Treaty and were given the accession number ATCC 98872, from which each clone comprising a particular polynucleotide is obtainable. 
     Clones ya66 — 1, yb187 — 1, yb219 — 1, yb228 — 1, yc27 — 1, yc49 — 1, yd40 — 1, yd64 — 1, ye47 — 1, yh50 — 1, yh53 — 1, and yh98 — 1 were deposited on Sep. 23, 1998 with the American Type Culture Collection (10801 University Boulevard, Manassas, Va. 20110-2209 U.S.A.) as an original deposit under the Budapest Treaty and were given the accession number. ATCC 98887, from which each clone comprising a particular polynucleotide is obtainable. 
     Clones ya69 — 1, yd107 — 1, yd145 — 1, yh24 — 1, yi11 — 1, yi18 — 1, yk14 — 1, yk39 — 1, yk91 — 1, yk199 — 1, yl4 — 1, and yl14 — 1 were deposited on Oct. 6, 1998 with the American Type Culture Collection (10801 University Boulevard, Manassas, Va. 20110-2209 U.S.A.) as an original deposit under the Budapest Treaty and were given the accession number ATCC 98915, from which each clone comprising a particular polynucleotide is obtainable. 
     Clones ya80 — 1, yd61 — 1, yd88 — 1, yd109 — 1, yd141 — 1, yd153 — 1, yd165 — 1, yd178 — 1, and yd191 — 1 were deposited on Oct. 15, 1998 with the American Type Culture Collection (10801 University Boulevard, Manassas, Va. 20110-2209 U.S.A.) as an original deposit under the Budapest Treaty and were given the accession number ATCC 98925, from which each clone comprising a particular polynucleotide is obtainable. 
     Clones ye7 — 1, yf33 — 1, yi15 — 1, yi17 — 1, yk38 — 1, yk51 — 1, yk74 — 1, yk89 — 1, yk18 — 1 were deposited on Oct. 15, 1998 with the American Type Culture Collection (10801 University Boulevard, Manassas, Va. 20110-2209 U.S.A.) as an original deposit under the Budapest Treaty and were given the accession number ATCC 98924, from which each clone comprising a particular polynucleotide is obtainable. 
     Clones yb235 — 1, yd261 — 1, yh33 — 1, yi16 — 1, yk46 — 1, yk84 — 1, yk143 — 1, yk156 — 1, yk204 — 1, yk224 — 1, yk261 — 1, ys3 — 1, and ys10 — 1 were deposited on Oct. 27, 1998 with the American Type Culture Collection (10801 University Boulevard, Manassas, Va. 20110-2209 U.S.A.) as an original deposit under the Budapest Treaty and were given the accession number ATCC 98958, from which each clone comprising a particular polynucleotide is obtainable. 
     All restrictions on the availability to the public of the deposited material will be irrevocably removed upon the granting of the patent, except for the requirements specified in 37 C.F.R. § 1.808(b), and the term of the deposit will comply with 37 C.F.R. § 1.806. 
     Each clone has been transfected into separate bacterial cells ( E. coli ) in these composite deposits. Each clone can be removed from the vector in which it was deposited by performing an EcoRI/NotI digestion (5′ site, EcoRI; 3′ site, NotI) to produce the appropriate fragment for such clone. Each clone was deposited in either the pED6 or pNOTs vector depicted in FIGS. 1A and 1B, respectively. The pED6dpc2 vector (“pED6”) was derived from pED6dpc1 by insertion of a new polylinker to facilitate cDNA cloning (Kaufman et al., 1991 , Nucleic Acids Res . 19: 4485-4490); the pNOTs vector was derived from pMT2 (Kaufman et al., 1989 , Mol. Cell. Biol . 9: 946-958) by deletion of the DHFR sequences, insertion of a new polylinker, and insertion of the M13 origin of replication in the ClaI site. In some instances, the deposited clone can become “flipped” (i.e., in the reverse orientation) in the deposited isolate. In such instances, the cDNA insert can still be isolated by digestion with EcoRI and NotI. However, NotI will then produce the 5′ site and EcoRI will produce the 3′ site for placement of the cDNA in proper orientation for expression in a suitable vector. The cDNA may also be expressed from the vectors in which they were deposited. 
     Bacterial cells containing a particular clone can be obtained from the composite deposit as follows: 
     An oligonucleotide probe or probes should be designed to the sequence that is known for that particular clone. This sequence can be derived from the sequences provided herein, or from a combination of those sequences. The sequence of an oligonucleotide probe that was used to isolate or to sequence each full-length clone is identified below, and should be most reliable in isolating the clone of interest. 
     
       
         
           
               
               
               
             
               
                   
                   
               
               
                   
                 Clone 
                 Probe Sequence 
               
               
                   
                   
               
             
            
               
                   
                 ya15_1 
                 SEQ ID NO:215 
               
               
                   
                 ya24_1 
                 SEQ ID NO:216 
               
               
                   
                 yb42_1 
                 SEQ ID NO:217 
               
               
                   
                 yc9_1 
                 SEQ ID NO:218 
               
               
                   
                 yc19_1 
                 SEQ ID NO:219 
               
               
                   
                 yc20_1 
                 SEQ ID NO:220 
               
               
                   
                 ya9_1 
                 SEQ ID NO:221 
               
               
                   
                 ya28_1 
                 SEQ ID NO:222 
               
               
                   
                 yc14_1 
                 SEQ ID NO:223 
               
               
                   
                 yc24_1 
                 SEQ ID NO:224 
               
               
                   
                 yc25_1 
                 SEQ ID NO:225 
               
               
                   
                 ye2_1 
                 SEQ ID NO:226 
               
               
                   
                 yb60_1 
                 SEQ ID NO:227 
               
               
                   
                 yc29_1 
                 SEQ ID NO:228 
               
               
                   
                 yf5_1 
                 SEQ ID NO:229 
               
               
                   
                 ya70_1 
                 SEQ ID NO:230 
               
               
                   
                 yb51_1 
                 SEQ ID NO:231 
               
               
                   
                 yb101_1 
                 SEQ ID NO:232 
               
               
                   
                 yb124_1 
                 SEQ ID NO:233 
               
               
                   
                 yb125_1 
                 SEQ ID NO:234 
               
               
                   
                 yb179_1 
                 SEQ ID NO:235 
               
               
                   
                 ye21_1 
                 SEQ ID NO:236 
               
               
                   
                 ye22_1 
                 SEQ ID NO:237 
               
               
                   
                 yf9_1 
                 SEQ ID NO:238 
               
               
                   
                 yh71_1 
                 SEQ ID NO:239 
               
               
                   
                 yh100_1 
                 SEQ ID NO:240 
               
               
                   
                 yj23_1 
                 SEQ ID NO:241 
               
               
                   
                 yb187_1 
                 SEQ ID NO:242 
               
               
                   
                 yb219_1 
                 SEQ ID NO:243 
               
               
                   
                 yd40_1 
                 SEQ ID NO:244 
               
               
                   
                 ye47_1 
                 SEQ ID NO:245 
               
               
                   
                 yh50_1 
                 SEQ ID NO:246 
               
               
                   
                 yh53_1 
                 SEQ ID NO:247 
               
               
                   
                 ya69_1 
                 SEQ ID NO:248 
               
               
                   
                 yi11_1 
                 SEQ ID NO:249 
               
               
                   
                 yl4_1 
                 SEQ ID NO:250 
               
               
                   
                 ye7_1 
                 SEQ ID NO:251 
               
               
                   
                 yf33_1 
                 SEQ ID NO:252 
               
               
                   
                 yi15_1 
                 SEQ ID NO:253 
               
               
                   
                 yi17_1 
                 SEQ ID NO:254 
               
               
                   
                 yk38_1 
                 SEQ ID NO:255 
               
               
                   
                 yk89_1 
                 SEQ ID NO:256 
               
               
                   
                 yl18_1 
                 SEQ ID NO:257 
               
               
                   
                 yh33_1 
                 SEQ ID NO:258 
               
               
                   
                 yi16_1 
                 SEQ ID NO:259 
               
               
                   
                 yk46_1 
                 SEQ ID NO:260 
               
               
                   
                 yk84_1 
                 SEQ ID NO:261 
               
               
                   
                 yk204_1 
                 SEQ ID NO:262 
               
               
                   
                 yk224_1 
                 SEQ ID NO:263 
               
               
                   
                 yk261_1 
                 SEQ ID NO:264 
               
               
                   
                   
               
            
           
         
       
     
     In the sequences listed above which include an N at position 2, that position is occupied in preferred probes/primers by a biotinylated phosphoaramidite residue rather than a nucleotide (such as, for example, that produced by use of biotin phosphoramidite (1-dimethoxytrityloxy-2-(N-biotinyl-4-aminobutyl)-propyl-3-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramadite) (Glen Research, cat; no. 10-1953)). 
     The design of the oligonucleotide probe should preferably follow these parameters: 
     (a) It should be designed to an area of the sequence which has the fewest ambiguous bases (“N&#39;s”), if any; 
     (b) It should be designed to have a T m  of approx. 80° C. (assuming 2° for each A or T and 4 degrees for each G or C). 
     The oligonucleotide should preferably be labeled with γ- 32 P ATP (specific activity 6000 Ci/mmole) and T4 polynucleotide kinase using commonly employed techniques for labeling oligonucleotides. Other labeling techniques can also be used. Unincorporated label should preferably be removed by gel filtration chromatography or other established methods. The amount of radioactivity incorporated into the probe should be quantitated by measurement in a scintillation counter. Preferably, specific activity of the resulting probe should be approximately 4e+6 dpm/pmole. 
     The bacterial culture containing the pool of full-length clones should preferably be thawed and 100 μl of the stock used to inoculate a sterile culture flask containing 25 ml of sterile L-broth containing ampicillin at 100 μg/ml. The culture should preferably be grown to saturation at 37° C., and the saturated culture should preferably be diluted in fresh L-broth. Aliquots of these dilutions should preferably be plated to determine the dilution and volume which will yield approximately 5000 distinct and well-separated colonies on solid bacteriological media containing L-broth containing ampicillin at 100 μg/ml and agar at 1.5% in a 150 mm petri dish when grown overnight at 37° C. Other known methods of obtaining distinct, well-separated colonies can also be employed. 
     Standard colony hybridization procedures should then be used to transfer the colonies to nitrocellulose filters and lyse, denature and bake them. 
     The filter is then preferably incubated at 65° C. for 1 hour with gentle agitation in 6×SSC (20×stock is 175.3 g NaCl/liter, 88.2 g Na citrate/liter, adjusted to pH 7.0 with NaOH) containing 0.5% SDS, 100 μg/ml of yeast RNA, and 10 mM EDTA (approximately 10 mL per 150 mm filter). Preferably, the probe is then added to the hybridization mix at a concentration greater than or equal to 1e+6 dpm/mL. The filter is then preferably incubated at 65° C. with gentle agitation overnight. The filter is then preferably washed in 500 mL of 2×SSC/0.5% SDS at room temperature without agitation, preferably followed by 500 mL of 2×SSC/0.1% SDS at room temperature with gentle shaking for 15 minutes. A third wash with 0.1×SSC/0.5% SDS at 65° C. for 30 minutes to 1 hour is optional. The filter is then preferably dried and subjected to autoradiography for sufficient time to visualize the positives on the X-ray film. Other known hybridization methods can also be employed. 
     The positive colonies are picked, grown in culture, and plasmid DNA isolated using standard procedures. The clones can then be verified by restriction analysis, hybridization analysis, or DNA sequencing. 
     Fragments of the proteins of the present invention which are capable of exhibiting biological activity are also encompassed by the present invention. Fragments of the protein may be in linear form or they maybe cyclized using known methods, for example, as described in H. U. Saragovi, et al., Bio/Technology 10, 773-778 (1992) and in R. S. McDowell, et al., J. Amer. Chem. Soc. 114, 9245-9253 (1992), both of which are incorporated herein by reference. Such fragments may be fused to carrier molecules such as immunoglobulins for many purposes, including increasing the valency of protein binding sites. For example, fragments of the protein may be fused through “linker” sequences to the Fc portion of an immunoglobulin. For a bivalent form of the protein, such a fusion could be to the Fc portion of an IgG molecule. Other immunoglobulin isotypes may also be used to generate such fusions. For example, a protein—IgM fusion would generate a decavalent form of the protein of the invention. 
     The present invention also provides both full-length and mature forms of the disclosed proteins. The full-length form of the such proteins is identified in the sequence listing by translation of the nucleotide sequence of each disclosed clone. The mature form(s) of such protein may be obtained by expression of the disclosed full-length polynucleotide (preferably those deposited with ATCC) in a suitable mammalian cell or other host cell. The sequence(s) of the mature form(s) of the protein may also be determinable from the amino acid sequence of the full-length form. 
     The present invention also provides genes corresponding to the polynucleotide sequences disclosed herein. “Corresponding genes” are the regions of the genome that are transcribed to produce the mRNAs from which cDNA polynucleotide sequences are derived and may include contiguous regions of the genome necessary for the regulated expression of such genes. Corresponding genes may therefore include but are not limited to coding sequences, 5′ and 3′ untranslated regions, alternatively spliced exons, introns, promoters, enhancers, and silencer or suppressor elements. The corresponding genes can be isolated in accordance with known methods using the sequence information disclosed herein. Such methods include the preparation of probes or primers from the disclosed sequence information for identification and/or amplification of genes in appropriate genomic libraries or other sources of genomic materials. An “isolated gene” is a gene that has been separated from the adjacent coding sequences, if any, present in the genome of the organism from which the gene was isolated. 
     The chromosomal location corresponding to the polynucleotide sequences disclosed herein may also be determined, for example by hybridizing appropriately labeled polynucleotides of the present invention to chromosomes in situ. It may also be possible to determine the corresponding chromosomal location for a disclosed polynucleotide by identifying significantly similar nucleotide sequences in public databases, such as expressed sequence tags (ESTs), that have already been mapped to particular chromosomal locations. For at least some of the polynucleotide sequences disclosed herein, public database sequences having at least some similarity to the polynucleotide of the present invention have been listed by database accession number. Searches using the GenBank accession numbers of these public database sequences can then be performed at an Internet site provided by the National Center for Biotechnology Information having the address http://www.ncbi.nlm.nih.gov/UniGene/, in order to identify “UniGene clusters” of overlapping sequences. Many of the “UniGene clusters” so identified will already have been mapped to particular chromosomal sites. 
     Organisms that have enhanced, reduced, or modified expression of the gene(s) corresponding to the polynucleotide sequences disclosed herein are provided. The desired change in gene expression can be achieved through the use of antisense polynucleotides or ribozymes that bind and/or cleave the mRNA transcribed from the gene (Albert and Morris, 1994 , Trends Pharmacol. Sci . 15(7): 250-254; Lavarosky et al., 1997 , Biochem. Mol. Med . 62(1): 11-22; and Hampel, 1998 , Prog. Nucleic Acid Res. Mol. Biol . 58: 1-39; all of which are incorporated by reference herein). Transgenic animals that have multiple copies of the gene(s) corresponding to the polynucleotide sequences disclosed herein, preferably produced by transformation of cells with genetic constructs that are stably maintained within the transformed cells and their progeny, are provided. 
     Transgenic animals that have modified genetic control regions that increase or reduce gene expression levels, or that change temporal or spatial patterns of gene expression, are also provided (see European Patent No. 0 649 464 B1, incorporated by reference herein). 
     In addition, organisms are provided in which the gene(s) corresponding to the polynucleotide sequences disclosed herein have been partially or completely inactivated, through insertion of extraneous sequences into the corresponding gene(s) or through deletion of all or part of the corresponding gene(s). Partial or complete gene inactivation can be accomplished through insertion, preferably followed by imprecise excision, of transposable elements (Plasterk, 1992 , Bioessays  14(9): 629-633; Zwaal et al., 1993 , Proc. Natl. Acad. Sci. USA  90(16): 7431-7435; Clark et al., 1994 , Proc. Natl. Acad. Sci. USA  91(2): 719-722; all of which are incorporated by reference herein), or through homologous recombination, preferably detected by positive/negative genetic selection strategies (Mansour et al., 1988 , Nature  336: 348-352; U.S. Pat. Nos. 5,464,764; 5,487,992; 5,627,059; 5,631,153; 5,614,396; 5,616,491; and 5,679,523; all of which are incorporated by reference herein). These organisms with altered gene expression are preferably eukaryotes and more preferably are mammals. Such organisms are useful for the development of non-human models for the study of disorders involving the corresponding gene(s), and for the development of assay systems for the identification of molecules that interact with the protein product(s) of the corresponding gene(s). 
     Where the protein of the present invention is membrane-bound (e.g., is a receptor), the present invention also provides for soluble forms of such protein. In such forms, part or all of the intracellular and transmembrane domains of the protein are deleted such that the protein is fully secreted from the cell in which it is expressed. The intracellular and transmembrane domains of proteins of the invention can be identified in accordance with known techniques for determination of such domains from sequence information. For example, the TopPredII computer program can be used to predict the location of transmembrane domains in an amino acid sequence, domains which are described by the location of the center of the transmsmbrane domain, with at least ten transmembrane amino acids on each side of the reported central residue(s). 
     Proteins and protein fragments of the present invention include proteins with amino acid sequence lengths that are at least 25%(more preferably at least 50%, and most preferably at least 75%) of the length of a disclosed protein and have at least 60% sequence identity (more preferably, at least 75% identity; most preferably at least 90% or 95% identity) with that disclosed protein, where sequence identity is determined by comparing the amino acid sequences of the proteins when aligned so as to maximize overlap and identity while minimizing sequence gaps. Also included in the present invention are proteins and protein fragments that contain a segment preferably comprising 8 or more (more preferably 20 or more, most preferably 30 or more) contiguous amino acids that shares at least 75% sequence identity (more preferably, at least 85% identity; most preferably at least 95% identity) with any such segment of any of the disclosed proteins. 
     In particular, sequence identity may be determined using WU-BLAST (Washington University BLAST) version 2.0 software, which builds upon WU-BLAST version 1.4, which in turn is based on the public domain NCBI-BLAST version 1.4 (Altschul and Gish, 1996, Local alignment statistics, Doolittle ed.,  Methods in Enzymology  266: 460-480; Altschul et al., 1990, Basic local alignment search tool,  Journal of Molecular Biology  215: 403-410; Gish and States, 1993, Identification of protein coding regions by database similarity search,  Nature Genetics  3: 266-272; Karlin and Altschul, 1993, Applications and statistics for multiple high-scoring segments in molecular sequences,  Proc. Natl. Acad. Sci. USA  90: 5873-5877; all of which are incorporated by reference herein). WU-BLAST version 2.0 executable programs for several UNIX platforms can be downloaded from ftp://blast.wustl.edu/blast/executables. The complete suite of search programs (BLASTP, BLASTN, BLASTX, TBLASTN, and TBLASTX) is provided at that site, in addition to several support programs. WU-BLAST 2.0 is copyrighted and may not be sold or redistributed in any form or manner without the express written consent of the author; but the posted executables may otherwise be freely used for commercial, nonprofit, or academic purposes. In all search programs in the suite—BLASTP, BLASTN, BLASTX, TBLASTN and TBLASTX—the gapped alignment routines are integral to the database search itself, and thus yield much better sensitivity and selectivity while producing the more easily interpreted output. Gapping can optionally be turned off in all of these programs, if desired. The default penalty (Q) for a gap of length one is Q=9 for proteins and BLASTP, and Q=10 for BLASTN, but may be changed to any integer value including zero, one through eight, nine, ten, eleven, twelve through twenty, twenty-one through fifty, fifty-one through one hundred, etc. The default per-residue penalty for extending a gap (R) is R=2 for proteins and BLASTP, and R=10 for BLASTN, but may be changed to any integer value including zero, one, two, three, four, five, six, seven, eight, nine, ten, eleven, twelve through twenty, twenty-one through fifty, fifty-one through one hundred, etc. Any combination of values for Q and R can be used in order to align sequences so as to maximize overlap and identity while minimizing sequence gaps. The default amino acid comparison matrix is BLOSUM62, but other amino acid comparison matrices such as PAM can be utilized. 
     Species homologues of the disclosed polynucleotides and proteins are also provided by the present invention. As used herein, a “species homologue” is a protein or polynucleotide with a different species of origin from that of a given protein or polynucleotide, but with significant sequence similarity to the given protein or polynucleotide. Preferably, polynucleotide species homologues have at least 60% sequence identity (more preferably, at least 75% identity; most preferably at least 90% identity) with the given polynucleotide, and protein species homologues have at least 30% sequence identity (more preferably, at least 45% identity; most preferably at least 60% identity) with the given protein, where sequence identity is determined by comparing the nucleotide sequences of the polynucleotides or the amino acid sequences of the proteins when aligned so as to maximize overlap and identity while minimizing sequence gaps. Species homologues may be isolated and identified by making suitable probes or primers from the sequences provided herein and screening a suitable nucleic acid source from the desired species. Preferably, species homologues are those isolated from mammalian species. Most preferably, species homologues are those isolated from certain mammalian species such as, for example,  Pan troglodytes, Gorilla gorilla, Pongo pygmaeus, Hylobates concolor, Macaca mulatta, Papio papio, Papio hamadryas, Cercopithecus aethiops, Cebus capucinus, Aotus trivirgatus, Sanguinus oedipus, Microcebus murinus, Mus musculus, Rattus norvegicus, Cricetulus griseus, Felis catus, Mustela vzison, Canis familiaris, Oryctolagus cuniculus, Bos taurus, Ovis aries, Sus scrofa , and  Equus caballus , for which genetic maps have been created allowing the identification of syntenic relationships between the genomic organization of genes in one species and the genomic organization of the related genes in another species (O&#39;Brien and Seuanez, 1988 , Ann. Rev. Genet . 22: 323-351; O&#39;Brien et al., 1993 , Nature Genetics  3:103-112; Johansson et al., 1995 , Genomics  25: 682-690; Lyons et al., 1997 , Nature Genetics  15:47-56; O&#39;Brien et al., 1997 , Trends in Genetics  13(10): 393-399; Carver and Stubbs, 1997 , Genome Research  7:1123-1137; all of which are incorporated by reference herein). 
     The invention also encompasses allelic variants of the disclosed polynucleotides or proteins; that is, naturally-occurring alternative forms of the isolated polynucleotides which also encode proteins which are identical or have significantly similar sequences to those encoded by the disclosed polynucleotides. Preferably, allelic variants have at least 60% sequence identity (more preferably, at least 75% identity; most preferably at least 90% identity) with the given polynucleotide, where sequence identity is determined by comparing the nucleotide sequences of the polynucleotides when aligned so as to maximize overlap and identity while minimizing sequence gaps. Allelic variants may be isolated and identified by making suitable probes or primers from the sequences provided herein and screening a suitable nucleic acid source from individuals of the appropriate species. 
     The invention also includes polynucleotides with sequences complementary to those of the polynucleotides disclosed herein. 
     The present invention also includes polynucleotides that hybridize under reduced stringency conditions, more preferably stringent conditions, and most preferably highly stringent conditions, to polynucleotides described herein. Examples of stringency conditions are shown in the table below: highly stringent conditions are those that are at least as stringent as, for example, conditions A-F; stringent conditions are at least as stringent as, for example, conditions G-L; and reduced stringency conditions are at least as stringent as, for example, conditions M-R. 
     
       
         
           
               
               
               
               
               
             
               
                   
               
               
                 Strin- 
                   
                   
                   
                   
               
               
                 gency 
                 Poly- 
                 Hybrid 
                 Hybridization 
                 Wash 
               
               
                 Con- 
                 nucleotide 
                 Length 
                 Temperature and 
                 Temperature 
               
               
                 dition 
                 Hybrid 
                 (bp) ‡   
                 Buffer †   
                 and Buffer †   
               
               
                   
               
             
            
               
                 A 
                 DNA:DNA 
                 ≧50 
                 65° C.; 1 × SSC -or- 
                 65° C.; 0.3 × 
               
               
                   
                   
                   
                 42° C.; 1 × SSC, 50% 
                 SSC 
               
               
                   
                   
                   
                 formamide 
               
               
                 B 
                 DNA:DNA 
                 &lt;50 
                 T B *; 1 × SSC 
                 T B *; 1 × SSC 
               
               
                 C 
                 DNA:RNA 
                 ≧50 
                 67° C.; 1 × SSC -or- 
                 67° C.; 0.3 × 
               
               
                   
                   
                   
                 45° C.; 1 × SSC, 50% 
                 SSC 
               
               
                   
                   
                   
                 formamide 
               
               
                 D 
                 DNA:RNA 
                 &lt;50 
                 T D *; 1 × SSC 
                 T D *; 1 × SSC 
               
               
                 E 
                 RNA:RNA 
                 ≧50 
                 70° C.; 1 × SSC -or- 
                 70° C.; 0.3 × 
               
               
                   
                   
                   
                 50° C.; 1 × SSC, 50% 
                 SSC 
               
               
                   
                   
                   
                 formamide 
               
               
                 F 
                 RNA:RNA 
                 &lt;50 
                 T F *; 1 × SSC 
                 T F *; 1 × SSC 
               
               
                 G 
                 DNA:DNA 
                 ≧50 
                 65° C.; 4 × SSC -or- 
                 65° C.; 1 × 
               
               
                   
                   
                   
                 42° C.; 4 × SSC, 50% 
                 SSC 
               
               
                   
                   
                   
                 formamide 
               
               
                 H 
                 DNA:DNA 
                 &lt;50 
                 T H *; 4 × SSC 
                 T H *; 4 × SSC 
               
               
                 I 
                 DNA:RNA 
                 ≧50 
                 67° C.; 4 × SSC -or- 
                 67° C.; 1 × 
               
               
                   
                   
                   
                 45° C.; 4 × SSC, 50% 
                 SSC 
               
               
                   
                   
                   
                 formamide 
               
               
                 J 
                 DNA:RNA 
                 &lt;50 
                 T J *; 4 × SSC 
                 T J *; 4 × SSC 
               
               
                 K 
                 RNA:RNA 
                 ≧50 
                 70° C.; 4 × SSC -or- 
                 67° C.; 1 × 
               
               
                   
                   
                   
                 50° C.; 4 × SSC, 50% 
                 SSC 
               
               
                   
                   
                   
                 formamide 
               
               
                 L 
                 RNA:RNA 
                 &lt;50 
                 T L *; 2 × SSC 
                 T L *; 2 × SSC 
               
               
                 M 
                 DNA:DNA 
                 ≧50 
                 50° C.; 4 × SSC -or- 
                 50° C.; 2 × 
               
               
                   
                   
                   
                 40° C.; 6 × SSC, 50% 
                 SSC 
               
               
                   
                   
                   
                 formamide 
               
               
                 N 
                 DNA:DNA 
                 &lt;50 
                 T N *; 6 × SSC 
                 T N *; 6 × SSC 
               
               
                 O 
                 DNA:RNA 
                 ≧50 
                 55° C.; 4 × SSC -or- 
                 55° C.; 2 × 
               
               
                   
                   
                   
                 42° C.; 6 × SSC, 50% 
                 SSC 
               
               
                   
                   
                   
                 formamide 
               
               
                 P 
                 DNA:RNA 
                 &lt;50 
                 T P *; 6 × SSC 
                 T P *; 6 × SSC 
               
               
                 Q 
                 RNA:RNA 
                 ≧50 
                 60° C.; 4 × SSC -or- 
                 60° C.; 2 × 
               
               
                   
                   
                   
                 45° C.; 6 × SSC, 50% 
                 SSC 
               
               
                   
                   
                   
                 formamide 
               
               
                 R 
                 RNA:RNA 
                 &lt;50 
                 T R *; 4 × SSC 
                 T R *; 4 × SSC 
               
               
                   
               
               
                   ‡ The hybrid length is that anticipated for the hybridized region(s) of the hybridizing polynucleotides. When hybridizing a polynucleotide to a target polynucleotide of unknown sequence, the hybrid length is assumed to be that of the hybridizing polynucleotide. When polynucleotides of known sequence are hybridized, the hybrid length can be determined by aligning the sequences of the polynucleotides and identifying the region or regions of optimal sequence complementarity.  
               
               
                   † SSPE (1 × SSPE is 0.15M NaCl, 10 mM NaH 2 PO 4 , and 1.25 mM EDTA, pH 7.4) can be substituted for SSC (1 × SSC is 0.15M NaCl and 15 mM sodium citrate) in the hybridization and wash buffers; washes are performed for 15 minutes after hybridization is complete.  
               
               
                 *T B -T R : The hybridization temperature for hybrids anticipated to be less than 50 base pairs in length should be 5-10° C. less than the melting temperature (T m ) of the hybrid, where T m  is determined according to the following equations. For hybrids less than 18 base pairs in length, T m (° C.) = 2(# of A + T bases) + 4(# of G +  
               
               
                 # C bases). For hybrids between 18 and 49 base pairs in length, T m (° C.) = 81.5 + 16.6(log 10 [Na + ]) + 0.41(% G + C) − (600/N), where N is the number of bases in the hybrid, and [Na + ] is the concentration of sodium ions in the hybridization buffer ([Na + ] for 1 × SSC = 0.165M).  
               
            
           
         
       
     
     Additional examples of stringency conditions for polynucleotide hybridization are provided in Sambrook, J., E. F. Fritsch, and T. Maniatis, 1989 , Molecular Cloning: A Laboratory Manual , Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., chapters 9 and 11, and  Current Protocols in Molecular Biology , 1995, F. M. Ausubel et al., eds., John Wiley &amp; Sons, Inc., sections 2.10 and 6.3-6.4, incorporated herein by reference. 
     Preferably, each such hybridizing polynucleotide has a length that is at least 25% (more preferably at least 50%, and most preferably at least 75%) of the length of the polynucleotide of the present invention to which it hybridizes, and has at least 60% sequence identity (more preferably, at least 75% identity; most preferably at least 90% or 95% identity) with the polynucleotide of the present invention to which it hybridizes, where sequence identity is determined by comparing the sequences of the hybridizing polynucleotides when aligned so as to maximize overlap and identity while minimizing sequence gaps. 
     The isolated polynucleotide endcoing the protein of the invention may be operably linked to an expression control sequence such as the pMT2 or pED expression vectors disclosed in Kaufman et al., Nucleic Acids Res. 19, 4485-4490 (1991), in order to produce the protein recombinantly. Many suitable expression control sequences are known in the art. General methods of expressing recombinant proteins are also known and are exemplified in R. Kaufman, Methods in Enzymology 185, 537-566 (1990). As defined herein “operably linked” means that the isolated polynucleotide of the invention and an expression control sequence are situated within a vector or cell in such a way that the protein is expressed by a host cell which has been transformed (transfected) with the ligated polynucleotide/expression control sequence. 
     A number of types of cells may act as suitable host cells for expression of the protein. Mammalian host cells include, for example, monkey COS cells, Chinese Hamster Ovary (CHO) cells, human kidney 293 cells, human epidermal A431 cells, human Colo205 cells, 3T3 cells, CV-1 cells, other transformed primate cell lines, normal diploid cells, cell strains derived from in vitro culture of primary tissue, primary explants, HeLa cells, mouse L cells, BHK, HL-60, U937, HaK or Jurkat cells. 
     Alternatively, it may be possible to produce the protein in lower eukaryotes such as yeast or in prokaryotes such as bacteria. Potentially suitable yeast strains include  Saccharomyces cerevisiae, Schizosaccharomyces pombe , Kluyveromyces strains, Candida, or any yeast strain capable of expressing heterologous proteins. Potentially suitable bacterial strains include  Escherichia coli, Bacillus subtilis, Salmonella typhimurium , or any bacterial strain capable of expressing heterologous proteins. If the protein is made in yeast or bacteria, it may be necessary to modify the protein produced therein, for example by phosphorylation or glycosylation of the appropriate sites, in order to obtain the functional protein. Such covalent attachments may be accomplished using known chemical or enzymatic methods. 
     The protein may also be produced by operably linking the isolated polynucleotide of the invention to suitable control sequences in one or more insect expression vectors, and employing an insect expression system. Materials and methods for baculovirus/insect cell expression systems are commercially available in kit form from, e.g., Invitrogen, San Diego, Calif., U.S.A. (the MaxBac® kit), and such methods are well known in the art, as described in Summers and Smith,  Texas Agricultural Experiment Station Bulletin No . 1555 (1987) incorporated herein by reference. As used herein, an insect cell capable of expressing a polynucleotide of the present invention is “transformed.” 
     The protein of the invention may be prepared by culturing transformed host cells under culture conditions suitable to express the recombinant protein. The resulting expressed protein may then be purified from such culture (i.e., from culture medium or cell extracts) using known purification processes, such as gel filtration and ion exchange chromatography. The purification of the protein may also include an affinity column containing agents which will bind to the protein; one or more column steps over such affinity resins as concanavalin A-agarose, heparin-toyopearl® or Cibacrom blue 3GA Sepharose®; one or more steps involving hydrophobic interaction chromatography using such resins as phenyl ether, butyl ether, or propyl ether; or immunoaffinity chromatography. 
     Alternatively, the protein of the invention may also be expressed in a form which will facilitate purification. For example, it may be expressed as a fusion protein, such as those of maltose binding protein (MBP), glutathione-S-transferase (GST) or thioredoxin (TRX). Kits for expression and purification of such fusion proteins are commercially available from New England BioLabs (Beverly, Mass.), Pharmacia (Piscataway, N.J.) and Invitrogen Corporation (Carlsbad, Calif.), respectively. The protein can also be tagged with an epitope and subsequently purified by using a specific antibody directed to such epitope. One such epitope (“Flag”) is commercially available from the Eastman Kodak Company (New Haven, Conn.). 
     Finally, one or more reverse-phase high performance liquid chromatography (RP-HPLC) steps employing hydrophobic RP-HPLC media, e.g., silica gel having pendant methyl or other aliphatic groups, can be employed to further purify the protein. Some or all of the foregoing purification steps, in various combinations, can also be employed to provide a substantially homogeneous isolated recombinant protein. The protein thus purified is substantially free of other mammalian proteins and is defined in accordance with the present invention as an “isolated protein.” 
     The protein of the invention may also be expressed as a product of transgenic animals, e.g., as a component of the milk of transgenic cows, goats, pigs, or sheep which are characterized by somatic or germ cells containing a nucleotide sequence encoding the protein. 
     The protein may also be produced by known conventional chemical synthesis. Methods for constructing the proteins of the present invention by synthetic means are known to those skilled in the art. The synthetically-constructed protein sequences, by virtue of sharing primary, secondary or tertiary structural and/or conformational characteristics with proteins may possess biological properties in common therewith, including protein activity. Thus, they may be employed as biologically active or immunological substitutes for natural, purified proteins in screening of therapeutic compounds and in immunological processes for the development of antibodies. 
     The proteins provided herein also include proteins characterized by amino acid sequences similar to those of purified proteins but into which modification are naturally provided or deliberately engineered. For example, modifications in the peptide or DNA sequences can be made by those skilled in the art using known techniques. Modifications of interest in the protein sequences may include the alteration, substitution, replacement, insertion or deletion of a selected amino acid residue in the coding sequence. For example, one or more of the cysteine residues may be deleted or replaced with another amino acid to alter the conformation of the molecule. Techniques for such alteration, substitution, replacement, insertion or deletion are well known to those skilled in the art (see, e.g., U.S. Pat. No. 4,518,584). Preferably, such alteration, substitution, replacement, insertion or deletion retains the desired activity of the protein. 
     Other fragments and derivatives of the sequences of proteins which would be expected to retain protein activity in whole or in part and may thus be useful for screening or other immunological methodologies may also be easily made by those skilled in the art given the disclosures herein. Such modifications are believed to be encompassed by the present invention. 
     USES AND BIOLOGICAL ACTIVITY 
     The polynucleotides and proteins of the present invention are expected to exhibit one or more of the uses or biological activities (including those associated with assays cited herein) identified below. Uses or activities described for proteins of the present invention may be provided by administration or use of such proteins or by administration or use of polynucleotides encoding such proteins (such as, for example, in gene therapies or vectors suitable for introduction of DNA). 
     Research Uses and Utilities 
     The polynucleotides provided by the present invention can be used by the research community for various purposes. The polynucleotides can be used to express recombinant protein for analysis, characterization or therapeutic use; as markers for tissues in which the corresponding protein is preferentially expressed (either constitutively or at a particular stage of tissue differentiation or development or in disease states); as molecular weight markers on Southern gels; as chromosome markers or tags (when labeled) to identify chromosomes or to map related gene positions; to compare with endogenous DNA sequences in patients to identify potential genetic disorders; as probes to hybridize and thus discover novel, related DNA sequences; as a source of information to derive PCR primers for genetic fingerprinting; as a probe to “subtract-out” known sequences in the process of discovering other novel polynucleotides; for selecting and making oligomers for attachment to a “gene chip” or other support, including for examination of expression patterns; to raise anti-protein antibodies using DNA immunization techniques; and as an antigen to raise anti-DNA antibodies or elicit another immune response. Where the polynucleotide encodes a protein which binds or potentially binds to another protein (such as, for example, in a receptor-ligand interaction), the polynucleotide can also be used in interaction trap assays (such as, for example, those described in Gyuris et al., 1993 , Cell  75: 791-803 and in Rossi et al., 1997 , Proc. Natl. Acad. Sci. USA  94: 8405-8410, all of which are incorporated by reference herein) to identify polynucleotides encoding the other protein with which binding occurs or to identify inhibitors of the binding interaction. 
     The proteins provided by the present invention can similarly be used in assay to determine biological activity, including in a panel of multiple proteins for high-throughput screening; to raise antibodies or to elicit another immune response; as a reagent (including the labeled reagent) in assays designed to quantitatively determine levels of the protein (or its receptor) in biological fluids; as markers for tissues in which the corresponding protein is preferentially expressed (either constitutively or at a particular stage of tissue differentiation or development or in a disease state); and, of course, to isolate correlative receptors or ligands. Where the protein binds or potentially binds to another protein (such as, for example, in a receptor-ligand interaction), the protein can be used to identify the other protein with which binding occurs or to identify inhibitors of the binding interaction. Proteins involved in these binding interactions can also be used to screen for peptide or small molecule inhibitors or agonists of the binding interaction. 
     Any or all of these research utilities are capable of being developed into reagent grade or kit format for commercialization as research products. 
     Methods for performing the uses listed above are well known to those skilled in the art. References disclosing such methods include without limitation “Molecular Cloning: A Laboratory Manual”, 2d ed., Cold Spring Harbor Laboratory Press, Sambrook, J., E. F. Fritsch and T. Maniatis eds., 1989, and “Methods in Enzymology: Guide to Molecular Cloning Techniques”, Academic Press, Berger, S. L. and A. R. Kimmel eds., 1987. 
     Nutritional Uses 
     Polynucleotides and proteins of the present invention can also be used as nutritional sources or supplements. Such uses include without limitation use as a protein or amino acid supplement, use as a carbon source, use as a nitrogen source and use as a source of carbohydrate. In such cases the protein or polynucleotide of the invention can be added to the feed of a particular organism or can be administered as a separate solid or liquid preparation, such as in the form of powder, pills, solutions, suspensions or capsules. In the case of microorganisms, the protein or polynucleotide of the invention can be added to the medium in or on which the microorganism is cultured. 
     Cytokine and Cell Proliferation/Differentiation Activity 
     A protein of the present invention may exhibit cytokine, cell proliferation (either inducing or inhibiting) or cell differentiation (either inducing or inhibiting) activity or may induce production of other cytokines in certain cell populations. Many protein factors discovered to date, including all known cytokines, have exhibited activity in one or more factor-dependent cell proliferation assays, and hence the assays serve as a convenient confirmation of cytokine activity. The activity of a protein of the present invention is evidenced by any one of a number of routine factor dependent cell proliferation assays for cell lines including, without limitation, 32D, DA2, DA1G, T10, B9, B9/11, BaF3, MC9/G, M+ (preB M+), 2E8, RB5, DA1, 123, T1165, HT2, CTLL2, TF-1, Mo7e and CMK. 
     The activity of a protein of the invention may, among other means, be measured by the following methods: 
     Assays for T-cell or thymocyte proliferation include without limitation those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function 3.1-3.19; Chapter 7, Immunologic studies in Humans); Takai et al., J. Immunol. 137:3494-3500, 1986; Bertagnolli et al., J. Immunol. 145:1706-1712, 1990; Bertagnolli et al., Cellular Immunology 133:327-341, 1991; Bertagnolli, et al., J. Immunol. 149:3778-3783, 1992; Bowman et al., J. Immunol. 152: 1756-1761, 1994. 
     Assays for cytokine production and/or proliferation of spleen cells, lymph node cells or thymocytes include, without limitation, those described in: Polyclonal T cell stimulation, Kruisbeek, A. M. and Shevach, E. M. In  Current Protocols in Immunology . J. E. e.a. Coligan eds. Vol 1 pp. 3.12.1-3.12.14, John Wiley and Sons, Toronto. 1994; and Measurement of mouse and human Interferon γ, Schreiber, R. D. In  Current Protocols in Immunology . J. E. e.a. Coligan eds. Vol 1 pp. 6.8.1-6.8.8, John Wiley and Sons, Toronto. 1994. 
     Assays for proliferation and differentiation of hematopoietic and lymphopoietic cells include, without limitation, those described in: Measurement of Human and Murine Interleukin 2 and Interleukin 4, Bottomly, K., Davis, L. S. and Lipsky, P. E. In  Current Protocols in Immunology . J. E. e.a. Coligan eds. Vol 1 pp. 6.3.1-6.3.12, John Wiley and Sons, Toronto. 1991; deVries et al., J. Exp. Med. 173:1205-1211, 1991; Moreau et al., Nature 336:690-692, 1988; Greenberger et al., Proc. Natl. Acad. Sci. U.S.A. 80:2931-2938, 1983; Measurement of mouse and human interleukin 6—Nordan, R. In  Current Protocols in Immunology . J. E. e.a. Coligan eds. Vol 1 pp. 6.6.1-6.6.5, John Wiley and Sons, Toronto. 1991; Smith et al., Proc. Natl. Acad. Sci. U.S.A. 83:1857-1861, 1986; Measurement of human Interleukin 11—Bennett, F., Giannotti, J., Clark, S. C. and Turner, K. J. In  Current Protocols in Immunology . J. E. e.a. Coligan eds. Vol 1 pp. 6.15.1 John Wiley and Sons, Toronto. 1991; Measurement of mouse and human Interleukin 9—Ciarletta, A., Giannotti, J., Clark, S. C. and Turner, K. J. In  Current Protocols in Immunology . J. E. e.a. Coligan eds. Vol 1 pp. 6.13.1, John Wiley and Sons, Toronto. 1991. 
     Assays for T-cell clone responses to antigens (which will identify, among others, proteins that affect APC-T cell interactions as well as direct T-cell effects by measuring proliferation and cytokine production) include, without limitation, those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function; Chapter 6, Cytokines and their cellular receptors; Chapter 7, Immunologic studies in Humans); Weinberger et al., Proc. Natl. Acad. Sci. USA 77:6091-6095, 1980; Weinberger et al., Eur. J. Immun. 11:405-411, 1981; Takai et al., J. Immunol. 137:3494-3500, 1986; Takai et al., J. Immunol. 140:508-512, 1988. 
     Immune Stimulating or Suppressing Activity 
     A protein of the present invention may also exhibit immune stimulating or immune suppressing activity, including without limitation the activities for which assays are described herein. A protein may be useful in the treatment of various immune deficiencies and disorders (including severe combined immunodeficiency (SCID)), e.g., in regulating (up or down) growth and proliferation of T and/or B lymphocytes, as well as effecting the cytolytic activity of NK cells and other cell populations. These immune deficiencies may be genetic or be caused by viral (e.g., HIV) as well as bacterial or fungal infections, or may result from autoimmune disorders. More specifically, infectious diseases causes by viral, bacterial, fungal or other infection may be treatable using a protein of the present invention, including infections by HIV, hepatitis viruses, herpesviruses, mycobacteria, Leishmania spp., malaria spp. and various fungal infections such as candidiasis. Of course, in this regard, a protein of the present invention may also be useful where a boost to the immune system generally may be desirable, i.e., in the treatment of cancer. 
     Autoimmune disorders which may be treated using a protein of the present invention include, for example, connective tissue disease, multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes mellitis, myasthenia gravis, graft-versus-host disease and autoimmune inflammatory eye disease. Such a protein of the present invention may also to be useful in the treatment of allergic reactions and conditions, such as asthma (particularly allergic asthma) or other respiratory problems. Other conditions, in which immune suppression is desired (including, for example, organ transplantation), may also be treatable using a protein of the present invention. 
     Using the proteins of the invention it may also be possible to regulate immune responses in a number of ways. Down regulation may be in the form of inhibiting or blocking an immune response already in progress or may involve preventing the induction of an immune response. The functions of activated T cells may be inhibited by suppressing T cell responses or by inducing specific tolerance in T cells, or both. Immunosuppression of T cell responses is generally an active, non-antigen-specific, process which requires continuous exposure of the T cells to the suppressive agent. Tolerance, which involves inducing non-responsiveness or energy in T cells, is distinguishable from immunosuppression in that it is generally antigen-specific and persists after exposure to the tolerizing agent has ceased. Operationally, tolerance can be demonstrated by the lack of a T cell response upon reexposure to specific antigen in the absence of the tolerizing agent. 
     Down regulating or preventing one or more antigen functions (including without limitation B lymphocyte antigen functions (such as, for example, B7)), e.g., preventing high level lymphokine synthesis by activated T cells, will be useful in situations of tissue, skin and organ transplantation and in graft-versus-host disease (GVHD). For example, blockage of T cell function should result in reduced tissue destruction in tissue transplantation. Typically, in tissue transplants, rejection of the transplant is initiated through its recognition as foreign by T cells, followed by an immune reaction that destroys the transplant. The administration of a molecule which inhibits or blocks interaction of a B7 lymphocyte antigen with its natural ligand(s) on immune cells (such as a soluble, monomeric form of a peptide having B7-2 activity alone or in conjunction with a monomeric form of a peptide having an activity of another B lymphocyte antigen (e.g., B7-1, B7-3) or blocking antibody), prior to transplantation can lead to the binding of the molecule to the natural ligand(s) on the immune cells without transmitting the corresponding costimulatory signal. Blocking B lymphocyte antigen function in this matter prevents cytokine synthesis by immune cells, such as T cells, and thus acts as an immunosuppressant. Moreover, the lack of costimulation may also be sufficient to anergize the T cells, thereby inducing tolerance in a subject. Induction of long-term tolerance by B lymphocyte antigen-blocking reagents may avoid the necessity of repeated administration of these blocking reagents. To achieve sufficient immunosuppression or tolerance in a subject, it may also be necessary to block the function of a combination of B lymphocyte antigens. 
     The efficacy of particular blocking reagents in preventing organ transplant rejection or GVHD can be assessed using animal models that are predictive of efficacy in humans. Examples of appropriate systems which can be used include allogeneic cardiac grafts in rats and xenogeneic pancreatic islet cell grafts in mice, both of which have been used to examine the immunosuppressive effects of CTLA4Ig fusion proteins in vivo as described in Lenschow et al., Science 257:789-792 (1992) and Turka et al., Proc. Natl. Acad. Sci USA, 89:11102-11105 (1992). In addition, murine models of GVHD (see Paul ed., Fundamental Immunology, Raven Press, New York, 1989, pp. 846-847) can be used to determine the effect of blocking B lymphocyte antigen function in vivo on the development of that disease. 
     Blocking antigen function may also be therapeutically useful for treating autoimmune diseases. Many autoimmune disorders are the result of inappropriate activation of T cells that are reactive against self tissue and which promote the production of cytokines and autoantibodies involved in the pathology of the diseases. Preventing the activation of autoreactive T cells may reduce or eliminate disease symptoms. Administration of reagents which block costimulation of T cells by disrupting receptor:ligand interactions of B lymphocyte antigens can be used to inhibit T cell activation and prevent production of autoantibodies or T cell-derived cytokines which may be involved in the disease process. Additionally, blocking reagents may induce antigen-specific tolerance of autoreactive T cells which could lead to long-term relief from the disease. The efficacy of blocking reagents in preventing or alleviating autoimmune disorders can be determined using a number of well-characterized animal models of. human autoimmune diseases. Examples include murine experimental autoimmune encephalitis, systemic lupus erythmatosis in MRL/lpr/lpr mice or NZB hybrid mice, murine autoimmune collagen arthritis, diabetes mellitus in NOD mice and BB rats, and murine experimental myasthenia gravis (see Paul ed., Fundamental Immunology, Raven Press, New York, 1989, pp. 840-856). 
     Upregulation of an antigen function (preferably a B lymphocyte antigen function), as a means of up regulating immune responses, may also be useful in therapy. Upregulation of immune responses may be in the form of enhancing an existing immune response or eliciting an initial immune response. For example, enhancing an immune response through stimulating B lymphocyte antigen function may be useful in cases of viral infection. In addition, systemic viral diseases such as influenza, the common cold, and encephalitis might be alleviated by the administration of stimulatory forms of B lymphocyte antigens systemically. 
     Alternatively, anti-viral immune responses may be enhanced in an infected patient by removing T cells from the patient, costimulating the T cells in vitro with viral antigen-pulsed APCs either expressing a peptide of the present invention or together with a stimulatory form of a soluble peptide of the present invention and reintroducing the in vitro activated T cells into the patient. Another method of enhancing anti-viral immune responses would be to isolate infected cells from a patient, transfect them with a nucleic acid encoding a protein of the present invention as described herein such that the cells express all or a portion of the protein on their surface, and reintroduce the transfected cells into the patient. The infected cells would now be capable of delivering a costimulatory signal to, and thereby activate, T cells in vivo. 
     In another application, up regulation or enhancement of antigen function (preferably B lymphocyte antigen function) may be useful in the induction of. tumor immunity. Tumor cells (e.g., sarcoma, melanoma, lymphoma, leukemia, neuroblastoma, carcinoma) transfected with a nucleic acid encoding at least one peptide of the present invention can be administered to a subject to overcome tumor-specific tolerance in the subject. If desired, the tumor cell can be transfected to express a combination of peptides. For example, tumor cells obtained from a patient can be transfected ex vivo with an expression vector directing the expression of a peptide having B7-2-like activity alone, or in conjunction with a peptide having B7-1-like activity and/or B7-3-like activity. The transfected tumor cells are returned to the patient to result in expression of the peptides on the surface of the transfected cell. Alternatively, gene therapy techniques can be used to target a tumor cell for transfection in vivo. 
     The presence of the peptide of the present invention having the activity of a B lymphocyte antigen(s) on the surface of the tumor cell provides the necessary costimulation signal to T cells to induce a T cell mediated immune response against the transfected tumor cells. In addition, tumor cells which lack MHC class I or MHC class II molecules, or which fail to reexpress sufficient amounts of MHC class I or MHC class II molecules, can be transfected with nucleic acid encoding all or a portion of (e.g., a cytoplasmic-domain truncated portion) of an MHC class I α chain protein and β 2  microglobulin protein or an MHC class II α chain protein and an MHC class II β chain protein to thereby express MHC class I or MHC class II proteins on the cell surface. Expression of the appropriate class I or class II MHC in conjunction with a peptide having the activity of a B lymphocyte antigen (e.g., B7-1, B7-2, B7-3) induces a T cell mediated immune response against the transfected tumor cell. Optionally, a gene encoding an antisense construct which blocks expression of an MHC class II associated protein, such as the invariant chain, can also be cotransfected with a DNA encoding a peptide having the activity of a B lymphocyte antigen to promote presentation of tumor associated antigens and induce tumor specific immunity. Thus, the induction of a T cell mediated immune response in a human subject may be sufficient to overcome tumor-specific tolerance in the subject. 
     The activity of a protein of the invention may, among other means, be measured by the following methods: 
     Suitable assays for thymocyte or splenocyte cytotoxicity include, without limitation, those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function 3.1-3.19; Chapter 7, Immunologic studies in Humans); Herrmann et al., Proc. Natl. Acad. Sci. USA 78:2488-2492, 1981; Herrmann et al., J. Immunol. 128:1968-1974, 1982; Handa et al., J. Immunol. 135:1564-1572, 1985; Takai et al., J. Immunol. 137:3494-3500, 1986; Takai et al., J. Immunol. 140:508-512, 1988; Herrmann et al., Proc. Natl. Acad. Sci. USA 78:2488-2492, 1981; Herrmann et al., J. Immunol. 128:1968-1974, 1982; Handa et al., J. Immunol. 135:1564-1572, 1985; Takai et al., J. Immunol. 137:3494-3500, 1986; Bowmanet al., J. Virology 61:1992-1998; Takai et al., J. Immunol. 140:508-512, 1988; Bertagnolr et al., Cellular Immunology 133:327-341, 1991; Brown et al., J. Immunol. 153:3079-3092, 1994. 
     Assays for T-cell-dependent immunoglobulin responses and isotype switching (which will identify, among others, proteins that modulate T-cell dependent antibody responses and that affect Th1/Th2 profiles) include, without limitation, those described in: Maliszewski, J. Immunol. 144:3028-3033, 1990; and Assays for B cell function: In vitro antibody production, Mond, J. J. and Brunswick, M. In  Current Protocols in Immunology . J. E. e.a. Coligan eds. Vol 1 pp. 3.8.1-3.8.16, John Wiley and Sons, Toronto. 1994. 
     Mixed lymphocyte reaction (MLR) assays (which will identify, among others, proteins that generate predominantly Th1 and CTL responses) include, without limitation, those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function 3.1-3.19; Chapter 7, Immunologic studies in Humans); Takai et al., J. Immunol. 137:3494-3500, 1986; Takai et al., J. Immunol. 140:508-512, 1988; Bertagnolli et al., J. Immunol. 149:3778-3783, 1992. 
     Dendritic cell-dependent assays (which will identify, among others, proteins expressed by dendritic cells that activate naive T-cells) include, without limitation, those described in: Guery et al., J. Immunol. 134:536-544, 1995; Inaba et al., Journal of Experimental Medicine 173:549-559, 1991; Macatonia et al., Journal of Immunology 154:5071-5079, 1995; Porgador et al., Journal of Experimental Medicine 182:255-260, 1995; Nair et al., Journal of Virology 67:4062-4069, 1993; Huang et al., Science 264:961-965, 1994; Macatonia et al., Journal of Experimental Medicine 169:1255-1264, 1989; Bhardwaj et al., Journal of Clinical Investigation 94:797-807, 1994; and Inaba et al., Journal of Experimental Medicine 172:631-640, 1990. 
     Assays for lymphocyte survival/apoptosis (which will identify, among others, proteins that prevent apoptosis after superantigen induction and proteins that regulate lymphocyte homeostasis) include, without limitation, those described in: Darzynkiewicz et al., Cytometry 13:795-808, 1992; Gorczyca et al., Leukemia 7:659-670, 1993; Gorczyca et al., Cancer Research 53:1945-1951, 1993; Itoh et al., Cell 66:233-243, 1991; Zacharchuk, Journal of Immunology 145:4037-4045, 1990; Zamai et al., Cytometry 14:891-897, 1993; Gorczyca et al., International Journal of Oncology 1:639-648, 1992. 
     Assays for proteins that influence early steps of T-cell commitment and development include, without limitation, those described in: Antica et al., Blood 84:111-117, 1994; Fine et al., Cellular Immunology 155:111-122, 1994; Galy et al., Blood 85:2770-2778, 1995; Toki et al., Proc. Nat. Acad Sci. USA 88:7548-7551, 1991. 
     Hematopoiesis Regulating Activity 
     A protein of the present invention may be useful in regulation of hematopoiesis and, consequently, in the treatment of myeloid or lymphoid cell deficiencies. Even marginal biological activity in support of colony forming cells or of factor-dependent cell lines indicates involvement in regulating hematopoiesis, e.g. in supporting the growth and proliferation of erythroid progenitor cells alone or in combination with other cytokines, thereby indicating utility, for example, in treating various anemias or for use in conjunction with irradiation/chemotherapy to stimulate the production of erythroid precursors and/or erythroid cells; in supporting the growth and proliferation of myeloid cells such as granulocytes and monocytes/macrophages (i.e., traditional CSF activity) useful, for example, in conjunction with chemotherapy to prevent or treat consequent myelo-suppression; in supporting the growth and proliferation of megakaryocytes and consequently of platelets thereby allowing prevention or treatment of various platelet disorders such as thrombocytopenia, and generally for use in place of or complimentary to platelet transfusions; and/or in supporting the growth and proliferation of hematopoietic stem cells which are capable of maturing to any and all of the above-mentioned hematopoietic cells and therefore find therapeutic utility in various stem cell disorders (such as those usually treated with transplantation, including, without limitation, aplastic anemia and paroxysmal nocturnal hemoglobinuria), as well as in repopulating the stem cell compartment post irradiation/chemotherapy, either in-vivo or ex-vivo (i.e., in conjunction with bone marrow transplantation or with peripheral progenitor cell transplantation (homologous or heterologous)) as normal cells or genetically manipulated for gene therapy. 
     The activity of a protein of the invention may, among other means, be measured by the following methods: 
     Suitable assays for proliferation and differentiation of various hematopoietic lines are cited above. 
     Assays for embryonic stem cell differentiation (which will identify; among others, proteins that influence embryonic differentiation hematopoiesis) include, without limitation, those described in: Johansson et al. Cellular Biology 15:141-151, 1995; Keller et al., Molecular and Cellular Biology 13:473486, 1993; McClanahan et al., Blood 81:2903-2915, 1993. 
     Assays for stem cell survival and differentiation (which will identify, among others, proteins that regulate lympho-hematopoiesis) include, without limitation, those described in: Methylcellulose colony forming assays, Freshney, M. G. In  Culture of Hematopoietic Cells . R. I. Freshney, et al. eds. Vol pp. 265-268, Wiley-Liss, Inc., New York, N.Y. 1994; Hirayama et al., Proc. Natl. Acad. Sci. USA 89:5907-5911, 1992; Primitive hematopoietic colony forming cells with high proliferative potential, McNiece, I. K. and Briddell, R. A. In  Culture of Hematopoietic Cells . R. I. Freshney, et al. eds. Vol pp. 23-39, Wiley-Liss, Inc., New York, N.Y. 1994; Neben et al., Experimental Hematology 22:353-359, 1994; Cobblestone area forming cell assay, Ploemacher, R. E. In  Culture of Hematopoietic Cells . R. I. Freshney, et al. eds. Vol pp. 1-21, Wiley-Liss, Inc., New York, N.Y. 1994; Long term bone marrow cultures in the presence of stromal cells, Spooncer, E., Dexter, M. and Allen, T. In  Culture of Hematopoietic Cells . R. I. Freshney, et al. eds. Vol pp. 163-179, Wiley-Liss, Inc., New York, N.Y. 1994; Long term culture initiating cell assay, Sutherland, H. J. In  Culture of Hematopoietic Cells . R. I. Freshney, et al. eds. Vol pp. 139-162, Wiley-Liss, Inc., New York, N.Y. 1994. 
     Tissue Growth Activity 
     A protein of the present invention also may have utility in compositions used for bone, cartilage, tendon, ligament and/or nerve tissue growth or regeneration, as well as for wound healing and tissue repair and replacement, and in the treatment of burns, incisions and ulcers. 
     A protein of the present invention, which induces cartilage and/or bone growth in circumstances where bone is not normally formed, has application in the healing of bone fractures and cartilage damage or defects in humans and other animals. Such a preparation employing a protein of the invention may have prophylactic use in closed as well as open fracture reduction and also in the improved fixation of artificial joints. De novo bone formation induced by an osteogenic agent contributes to the repair of congenital, trauma induced, or oncologic resection induced craniofacial defects, and also is useful in cosmetic plastic surgery. 
     A protein of this invention may also be used in the treatment of periodontal disease, and in other tooth repair processes. Such agents may provide an environment to attract bone-forming cells, stimulate growth of bone-forming cells -or induce differentiation of progenitors of bone-forming cells. A protein of the invention may also be useful in the treatment of osteoporosis or osteoarthritis, such as through stimulation of bone and/or cartilage repair or by blocking inflammation or processes of tissue destruction (collagenase activity, osteoclast activity, etc.) mediated by inflammatory processes. 
     Another category of tissue regeneration activity that may be attributable to the protein of the present invention is tendon/ligament formation. A protein of the present invention, which induces tendon/ligament-like tissue or other tissue formation in circumstances where such tissue is not normally formed, has application in the healing of tendon or ligament tears, deformities and other tendon or ligament defects in humans and other animals. Such a preparation employing a tendon/ligament-like tissue inducing protein may have prophylactic use in preventing damage to tendon or ligament tissue, as well as use in the improved fixation of tendon or ligament to bone or other tissues, and in repairing defects to tendon or ligament tissue. De novo tendon/ligament-like tissue formation induced by a composition of the present invention contributes to the repair of congenital, trauma induced, or other tendon or ligament defects of other origin, and is also useful in cosmetic plastic surgery for attachment or repair of tendons or ligaments. The compositions of the present invention may provide an environment to attract tendon- or ligament-forming cells, stimulate growth of tendon- or ligament-forming cells, induce differentiation of progenitors of tendon- or ligament-forming cells, or induce growth of tendon/ligament cells or progenitors ex vivo for return in vivo to effect tissue repair. The compositions of the invention may also be useful in the treatment of tendinitis, carpal tunnel syndrome and other tendon or ligament defects. The compositions may also include an appropriate matrix and/or sequestering agent as a carrier as is well known in the art. 
     The protein of the present invention may also be useful for proliferation of neural cells and for regeneration of nerve and brain tissue, i.e. for the treatment of central and peripheral nervous system diseases and neuropathies, as well as mechanical and traumatic disorders, which involve degeneration, death or trauma to neural cells or nerve tissue. More specifically, a protein may be used in the treatment of diseases of the peripheral nervous system, such as peripheral nerve injuries, peripheral neuropathy and localized neuropathies, and central nervous system diseases, such as Alzheimer&#39;s, Parkinson&#39;s disease, Huntington&#39;s disease, amyotrophic lateral sclerosis, and Shy-Drager syndrome. Further conditions which may be treated in accordance with the present invention include mechanical and traumatic disorders, such as spinal cord disorders, head trauma and cerebrovascular diseases such as stroke. Peripheral neuropathies resulting from chemotherapy or other medical therapies may also be treatable using a protein of the invention. 
     Proteins of the invention may also be useful to promote better or faster closure of non-healing wounds, including without limitation pressure ulcers, ulcers associated with vascular insufficiency, surgical and traumatic wounds, and the like. 
     It is expected that a protein of the present invention may also exhibit activity for generation or regeneration of other tissues, such as organs (including, for example, pancreas, liver, intestine, kidney, skin, endothelium), muscle (smooth, skeletal or cardiac) and vascular (including vascular endothelium) tissue, or for promoting the growth of cells comprising such tissues. Part of the desired effects may be by inhibition or modulation of fibrotic scarring to allow normal tissue to regenerate. A protein of the invention may also exhibit angiogenic activity. 
     A protein of the present invention may also be useful for gut protection or regeneration and treatment of lung or liver fibrosis, reperfusion injury in various tissues, and conditions resulting from systemic cytokine damage. 
     A protein of the present invention may also be useful for promoting or inhibiting differentiation of tissues described above from precursor tissues or cells; or for inhibiting the growth of tissues described above. 
     The activity of a protein of the invention may, among other means, be measured by the following methods: 
     Assays for tissue generation activity include, without limitation, those described in: International Patent Publication No. WO95/16035 (bone, cartilage, tendon); International Patent Publication No. WO95/05846 (nerve, neuronal); International Patent Publication No. WO91/07491 (skin, endothelium). 
     Assays for wound healing activity include, without limitation, those described in: Winter,  Epidermal Wound Healing  pps. 71-112 (Maibach, H I and Rovee, D T, eds.), Year Book Medical Publishers, Inc., Chicago, as modified by Eaglstein and Mertz, J. Invest. Dermatol 71:382-84 (1978). 
     Activin/Inhibin Activity 
     A protein of the present invention may also exhibit activin- or inhibin-related activities. Inhibins are characterized by their ability to inhibit the release of follicle stimulating hormone (FSH), while activins and are characterized by their ability to stimulate the release of follicle stimulating hormone (FSH). Thus, a protein of the present invention, alone or in heterodimers with a member of the inhibin a family, may be useful as a contraceptive based on the ability of inhibins to decrease fertility in female mammals and decrease spermatogenesis in male mammals. Administration of sufficient amounts of other inhibins can induce infertility in these mammals. Alternatively, the protein of the invention, as a homodimer or as a heterodimer with other protein subunits of the inhibin-β group, may be useful as a fertility inducing therapeutic, based upon the ability of activin molecules in stimulating FSH release from cells of the anterior pituitary. See, for example, U.S. Pat. No. 4,798,885. A protein of the invention may also be useful for advancement of the onset of fertility in sexually immature mammals, so as to increase the lifetime reproductive performance of domestic animals such as cows, sheep and pigs. 
     The activity of a protein of the invention may, among other means, be measured by the following methods: 
     Assays for activin/inhibin activity include, without limitation, those described in: Vale et al., Endocrinology 91:562-572, 1972; Ling et al., Nature 321:779-782, 1986; Vale et al., Nature 321:776-779, 1986; Mason et al., Nature 318:659-663, 1985; Forage et al., Proc. Natl. Acad. Sci. USA 83:3091-3095, 1986. 
     Chemotactic/Chemokinetic Activity 
     A protein of the present invention may have chemotactic or chemokinetic activity (e.g., act as a chemokine) for mammalian cells, including, for example, monocytes, fibroblasts, neutrophils, T-cells, mast cells, eosinophils, epithelial and/or endothelial cells. Chemotactic and chemokinetic proteins can be used to mobilize or attract a desired cell population to a desired site of action. Chemotactic or chemokinetic proteins provide particular advantages in treatment of wounds and other trauma to tissues, as well as in treatment of localized infections. For example, attraction of lymphocytes, monocytes or neutrophils to tumors or sites of infection may result in improved immune responses against the tumor or infecting agent. 
     A protein or peptide has chemotactic activity for a particular cell population if it can stimulate, directly or indirectly, the directed orientation or movement of such cell population. Preferably, the protein or peptide has the ability to directly stimulate directed movement of cells. Whether a particular protein has chemotactic activity for a population of cells can be readily determined by employing such protein or peptide in any known assay for cell chemotaxis. 
     The activity of a protein of the invention may, among other means, be measured by the following methods: 
     Assays for chemotactic activity (which will identify proteins that induce or prevent chemotaxis) consist of assays that measure the ability of a protein to induce the migration of cells across a membrane as well as the ability of a protein to induce the adhesion of one cell population to another cell population. Suitable assays for movement and adhesion include, without limitation, those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W. Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 6.12, Measurement of alpha and beta Chemokines 6.12.1-6.12.28; Taub et al. J. Clin. Invest. 95:1370-1376, 1995; Lind et al. APMIS 103:140-146, 1995; Muller et al Eur. J. Immunol. 25: 1744 — 1748; Gruber et al. J. of Immunol. 152:5860-5867, 1994; Johnston et al. J. of Immunol. 153: 1762-1768, 1994. 
     Hemostatic and Thrombolytic Activity 
     A protein of the invention may also exhibit hemostatic or thrombolytic activity. As a result, such a protein is expected to be useful in treatment of various coagulation disorders (including hereditary disorders, such as hemophilias) or to enhance coagulation and other hemostatic events in treating wounds resulting from trauma, surgery or other causes. A protein of the invention may also be useful for dissolving or inhibiting formation of thromboses and for treatment and prevention of conditions resulting therefrom (such as, for example, infarction of cardiac and central nervous system vessels (e.g., stroke). 
     The activity of a protein of the invention may, among other means, be measured by the following methods: 
     Assay for hemostatic and thrombolytic activity include, without limitation, those described in: Linet et al., J. Clin. Pharmacol. 26:131-140, 1986; Burdick et al., Thrombosis Res. 45:413-419, 1987; Humphrey et al., Fibrinolysis 5:71-79 (1991); Schaub, Prostaglandins 35:467-474, 1988. 
     Receptor/Ligand Activity 
     A protein of the present invention may also demonstrate activity as receptors, receptor ligands or inhibitors or agonists of receptor/ligand interactions. Examples of such receptors and ligands include, without limitation, cytokine receptors and their ligands, receptor kinases and their ligands, receptor phosphatases and their ligands, receptors involved in cell-cell interactions and their ligands (including without limitation, cellular adhesion molecules (such as selectins, integrins and their ligands) and receptor/ligand pairs involved in antigen presentation, antigen recognition and development of cellular and humoral immune responses). Receptors and ligands are also useful for screening of potential peptide or small molecule inhibitors of the relevant receptor/ligand interaction. A protein of the present invention (including, without limitation, fragments of receptors and ligands) may themselves be useful as inhibitors of receptor/ligand interactions. 
     The activity of a protein of the invention may, among other means, be measured by the following methods: 
     Suitable assays for receptor-ligand activity include without limitation those described in:Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W. Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 7.28, Measurement of Cellular Adhesion under static conditions 7.28.1-7.28.22), Takai et al., Proc. Natl. Acad. Sci. USA 84:6864-6868, 1987; Bierer et al., J. Exp. Med. 168:1145-1156, 1988; Rosenstein et al., J. Exp. Med. 169:149-160 1989; Stoltenborg et al., J. Immunol. Methods 175:59-68, 1994; Stitt et al., Cell 80:661-670, 1995. 
     Anti-inflammatory Activity 
     Proteins of the present invention may also exhibit anti-inflammatory activity. The anti-inflammatory activity may be achieved by providing a stimulus to cells involved in the inflammatory response, by inhibiting or promoting cell-cell interactions (such as, for example, cell adhesion), by inhibiting or promoting chemotaxis of cells involved in the inflammatory process, inhibiting or promoting cell extravasation, or by stimulating or suppressing production of other factors which more directly inhibit or promote an inflammatory response. Proteins exhibiting such activities can be used to treat inflammatory conditions including chronic or acute conditions), including without limitation inflammation associated with infection (such as septic shock, sepsis or systemic inflammatory response syndrome (SIRS)), ischemia-reperfusion injury, endotoxin lethality, arthritis, complement-mediated hyperacute rejection, nephritis, cytokine or chemokine-induced lung injury, inflammatory bowel disease, Crohn&#39;s disease or resulting from over production of cytokines such as TNF or IL-1. Proteins of the invention may also be useful to treat anaphylaxis and hypersensitivity to an antigenic substance or material. 
     Cadherin/Tumor Invasion Suppressor Activity 
     Cadherins are calcium-dependent adhesion molecules that appear to play major roles during development, particularly in defining specific cell types. Loss or alteration of normal cadherin expression can lead to changes in cell adhesion properties linked to tumor growth and metastasis. Cadherin malfunction is also implicated in other human diseases, such as pemphigus vulgaris and pemphigus foliaceus (auto-immune blistering skin diseases), Crohn&#39;s disease, and some developmental abnormalities. 
     The cadherin superfamily includes well over forty members, each with a distinct pattern of expression. All members of the superfamily have in common conserved extracellular repeats (cadherin domains), but structural differences are found in other parts of the molecule. The cadherin domains bind calcium to form their tertiary structure and thus calcium is required to mediate their adhesion. Only a few amino acids in the first cadherin domain provide the basis for homophilic adhesion; modification of this recognition site can change the specificity of a cadherin so that instead of recognizing only itself, the mutant molecule can now also bind to a different cadherin. In addition, some cadherins engage in heterophilic adhesion with other cadherins. 
     E-cadherin, one member of the cadherin superfamily, is expressed in epithelial cell types. Pathologically, if E-cadherin expression is lost in a tumor, the malignant cells become invasive and the cancer metastasizes. Transfection of cancer cell lines with polynucleotides expressing E-cadherin has reversed cancer-associated changes by returning altered cell shapes to normal, restoring cells&#39; adhesiveness to each other and to their substrate, decreasing the cell growth rate, and drastically reducing anchorage-independent cell growth. Thus, reintroducing E-cadherin expression reverts carcinomas to a less advanced stage. It is likely that other cadherins have the same invasion suppressor role in carcinomas derived from other tissue types. Therefore, proteins of the present invention with cadherin activity, and polynucleotides of the present invention encoding such proteins, can be used to treat cancer. Introducing such proteins or polynucleotides into cancer cells can reduce or eliminate the cancerous changes observed in these cells by providing normal cadherin expression. 
     Cancer cells have also been shown to express cadherins of a different tissue type than their origin, thus allowing these cells to invade and metastasize in a different tissue in the body. Proteins of the present invention with cadherin activity, and polynucleotides of the present invention encoding such proteins, can be substituted in these cells for the inappropriately expressed cadherins, restoring normal cell adhesive properties and reducing or eliminating the tendency of the cells to metastasize. 
     Additionally, proteins of the present invention with cadherin activity, and polynucleotides of the present invention encoding such proteins, can used to generate antibodies recognizing and binding to cadherins. Such antibodies can be used to block the adhesion of inappropriately expressed tumor-cell cadherins, preventing the cells from forming a tumor elsewhere. Such an anti-cadherin antibody can also be used as a marker for the grade, pathological type, and prognosis of a cancer, i.e. the more progressed the cancer, the less cadherin expression there will be, and this decrease in cadherin expression can be detected by the use of a cadherin-binding antibody. 
     Fragments of proteins of the present invention with cadherin activity, preferably a polypeptide comprising a decapeptide of the cadherin recognition site, and polynucleotides of the present invention encoding such protein fragments, can also be used to block cadherin function by binding to cadherins and preventing them from binding in ways that produce undesirable effects. Additionally, fragments of proteins of the present invention with cadherin activity, preferably truncated soluble cadherin fragments which have been found to be stable in the circulation of cancer patients, and polynucleotides encoding such protein fragments, can be used to disturb proper cell-cell adhesion. 
     Assays for cadherin adhesive and invasive suppressor activity include, without limitation, those described in: Hortsch et al. J Biol Chem 270 (32): 18809-18817, 1995; Miyaki et al. Oncogene 11: 2547-2552, 1995; Ozawa et al. Cell 63: 1033-1038, 1990. 
     Tumor Inhibition Activity 
     In addition to the activities described above for immunological treatment or prevention of tumors, a protein of the invention may exhibit other anti-tumor activities. A protein may inhibit tumor growth directly or indirectly (such as, for example, via antibody-dependent cell-mediated cytotoxicity (ADCC)). A protein may exhibit its tumor inhibitory activity by acting on tumor tissue or tumor precursor tissue, by inhibiting formation of tissues necessary to support tumor growth (such as, for example, by inhibiting angiogenesis), by causing production of other factors, agents or cell types which inhibit tumor growth, or by suppressing, eliminating or inhibiting factors, agents or cell types which promote tumor growth. 
     Other Activities 
     A protein of the invention may also exhibit one or more of the following additional activities or effects: inhibiting the growth, infection or function of, or killing, infectious agents, including, without limitation, bacteria, viruses, fungi and other parasites; effecting (suppressing or enhancing) bodily characteristics, including, without limitation, height, weight, hair color, eye color, skin, fat to lean ratio or other tissue pigmentation, or organ or body part size or shape (such as, for example, breast augmentation or diminution, change in bone form or shape); effecting biorhythms or caricadic cycles or rhythms; effecting the fertility of male or female subjects; effecting the metabolism, catabolism, anabolism, processing, utilization, storage or elimination of dietary fat, lipid, protein, carbohydrate, vitamins, minerals, cofactors or other nutritional factors or component(s); effecting behavioral characteristics, including, without limitation, appetite, libido, stress, cognition (including cognitive disorders), depression (including depressive disorders) and violent behaviors; providing analgesic effects or other pain reducing effects; promoting differentiation and growth of embryonic stem cells in lineages other than hematopoietic lineages; hormonal or endocrine activity; in the case of enzymes, correcting deficiencies of the enzyme and treating deficiency-related diseases; treatment of hyperproliferative disorders (such as, for example, psoriasis); immunoglobulin-like activity (such as, for example, the ability to bind antigens or complement); and the ability to act as an antigen in a vaccine composition to raise an immune response against such protein or another material or entity which is cross-reactive with such protein. 
     ADMINISTRATION AND DOSING 
     A protein of the present invention (from whatever source derived, including without limitation from recombinant and non-recombinant sources) may be used in a pharmaceutical composition when combined with a pharmaceutically acceptable carrier. 
     Such a composition may also contain (in addition to protein and a carrier) diluents, fillers, salts, buffers, stabilizers, solubilizers, and other materials well known in the art. The term “pharmaceutically acceptable” means a non-toxic material that does not interfere with the effectiveness of the biological activity of the active ingredient(s). The characteristics of the carrier will depend on the route of administration. The pharmaceutical composition of the invention may also contain cytokines, lymphokines, or other hematopoietic factors such as M-CSF, GM-CSF, TNF, IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IFN, TNF0, TNF1, TNF2, G-CSF, Meg-CSF, thrombopoietin, stem cell factor, and erythropoietin. The pharmaceutical composition may further contain other agents which either enhance the activity of the protein or compliment its activity or use in treatment. Such additional factors and/or agents may be included in the pharmaceutical composition to produce a synergistic effect with protein of the invention, or to minimize side effects. Conversely, protein of the present invention may be included in formulations of the particular cytokine, lymphokine, other hematopoietic factor, thrombolytic or anti-thrombotic factor, or anti-inflammatory agent to minimize side effects of the cytokine, lymphokine, other hematopoietic factor, thrombolytic or anti-thrombotic factor, or anti-inflammatory agent. 
     A protein of the present invention may be active in multimers (e.g., heterodimers or homodimers) or complexes with itself or other proteins. As a result, pharmaceutical compositions of the invention may comprise a protein of the invention in such multimeric or complexed form. 
     The pharmaceutical composition of the invention may be in the form of a complex of the protein(s) of present invention along with protein or peptide antigens. The protein and/or peptide antigen will deliver a stimulatory signal to both B and T lymphocytes. B lymphocytes will respond to antigen through their surface immunoglobulin receptor. T lymphocytes will respond to antigen through the T cell receptor (TCR) following presentation of the antigen by MHC proteins. MHC and structurally related proteins including those encoded by class I and class II MHC genes on host cells will serve to present the peptide antigen(s) to T lymphocytes. The antigen components could also be supplied as purified MHC-peptide complexes alone or with co-stimulatory molecules that can directly signal T cells. Alternatively antibodies able to bind surface immunolgobulin and other molecules on B cells as well as antibodies able to bind the TCR and other molecules on T cells can be combined with the pharmaceutical composition of the invention. 
     The pharmaceutical composition of the invention may be in the form of a liposome in which protein of the present invention is combined, in addition to other pharmaceutically acceptable carriers, with amphipathic agents such as lipids which exist in aggregated form as micelies, insoluble monolayers, liquid crystals, or lamellar layers in aqueous solution. Suitable lipids for liposomal formulation include, without limitation, monoglycerides, diglycerides, sulfatides, lysolecithin, phospholipids, saponin, bile acids, and the like. Preparation of such liposomal formulations is within the level of skill in the art, as disclosed, for example, in U.S. Pat. No. 4,235,871; U.S. Pat. No. 4,501,728; U.S. Pat. No. 4,837,028; and U.S. Pat. No. 4,737,323, all of which are incorporated herein by reference. 
     As used herein, the term “therapeutically effective amount” means the total amount of each active component of the pharmaceutical composition or method that is sufficient to show a meaningful patient benefit, i.e., treatment, healing, prevention or amelioration of the relevant medical condition, or an increase in rate of treatment, healing, prevention or amelioration of such conditions. When applied to an individual active ingredient, administered alone, the term refers to that ingredient alone. When applied to a combination, the term refers to combined amounts of the active ingredients that result in the therapeutic effect, whether administered in combination, serially or simultaneously. 
     In practicing the method of treatment or use of the present invention, a therapeutically effective amount of protein of the present invention is administered to a mammal having a condition to be treated. Protein of the present invention may be administered in accordance with the method of the invention either alone or in combination with other therapies such as treatments employing cytokines, lymphokines or other hematopoietic factors. When co-administered with one or more cytokines, lymphokines or other hematopoietic factors, protein of the present invention may be administered either simultaneously with the cytokine(s), lymphokine(s), other hematopoietic factor(s), thrombolytic or anti-thrombotic factors, or sequentially. If administered sequentially, the attending physician will decide on the appropriate sequence of administering protein of the present invention in combination with cytokine(s), lymphokine(s), other hematopoietic factor(s), thrombolytic or anti-thrombotic factors. 
     Administration of protein of the present invention used in the pharmaceutical composition or to practice the method of the present invention can be carried out in a variety of conventional ways, such as oral ingestion, inhalation, topical application or cutaneous, subcutaneous, intraperitoneal, parenteral or intravenous injection. Intravenous administration to the patient is preferred. 
     When a therapeutically effective amount of protein of the present invention is administered orally, protein of the present invention will be in the form of a tablet, capsule, powder, solution or elixir. When administered in tablet form, the pharmaceutical composition of the invention may additionally contain a solid carrier such as a gelatin or an adjuvant. The tablet, capsule, and powder contain from about 5 to 95% protein of the present invention, and preferably from about 25 to 90% protein of the present invention. When administered in liquid form, a liquid carrier such as water, petroleum, oils of animal or plant origin such as peanut oil, mineral oil, soybean oil, or sesame oil, or synthetic oils may be added. The liquid form of the pharmaceutical composition may further contain physiological saline solution, dextrose or other saccharide solution, or glycols such as ethylene glycol, propylene glycol or polyethylene glycol. When administered in liquid form, the pharmaceutical composition contains from about 0.5 to 90% by weight of protein of the present invention, and preferably from about 1 to 50% protein of the present invention. 
     When a therapeutically effective amount of protein of the present invention is administered by intravenous, cutaneous or subcutaneous injection, protein of the present invention will be in the form of a pyrogen-free, parenterally acceptable aqueous solution. The preparation of such parenterally acceptable protein solutions, having due regard to pH, isotonicity, stability, and the like, is within the skill in the art. A preferred pharmaceutical composition for intravenous, cutaneous, or subcutaneous injection should contain, in addition to protein of the present invention, an isotonic vehicle such as Sodium Chloride Injection, Ringer&#39;s Injection, Dextrose Injection, Dextrose and Sodium Chloride Injection, Lactated Ringer&#39;s Injection, or other vehicle as known in the art. The pharmaceutical composition of the present invention may also contain stabilizers, preservatives, buffers, antioxidants, or other additives known to those of skill in the art. 
     The amount of protein of the present invention in the pharmaceutical composition of the present invention will depend upon the nature and severity of the condition being treated, and on the nature of prior treatments which the patient has undergone. Ultimately, the attending physician will decide the amount of protein of the present invention with which to treat each individual patient. Initially, the attending physician will administer low doses of protein of the present invention and observe the patient&#39;s response. Larger doses of protein of the present invention may be administered until the optimal therapeutic effect is obtained for the patient, and at that point the dosage is not increased further. It is contemplated that the various pharmaceutical compositions;used to practice the method of the present invention should contain about 0.01 μg to about 100 mg (preferably about 0.1 ng to about 10 mg, more preferably about 0.1 μg to about 1 mg) of protein of the present invention per kg body weight. 
     The duration of intravenous therapy using the pharmaceutical composition of the present invention will vary, depending on the severity of the disease being treated and the condition and potential idiosyncratic response of each individual patient. It is contemplated that the duration of each application of the protein of the present invention will be in the range of 12 to 24 hours of continuous intravenous administration. Ultimately the attending physician will decide on the appropriate duration of intravenous therapy using the pharmaceutical composition of the present invention. 
     Protein of the invention may also be used to immunize animals to obtain polyclonal and monoclonal antibodies which specifically react with the protein. As used herein, the term “antibody” includes without limitation a polyclonal antibody, a monoclonal antibody, a chimeric antibody, a single-chain antibody, a CDR-grafted antibody, a humanized antibody, or fragments thereof which bind to the indicated protein. Such term also includes any other species derived from an antibody or antibody sequence which is capable of binding the indicated protein. 
     Antibodies to a particular protein can be produced by methods well known to those skilled in the art. For example, monoclonal antibodies can be produced by generation of antibody-producing hybridomas in accordance with known methods (see for example, Goding, 1983, Monoclonal antibodies: principles and practice, Academic Press Inc., New York; and Yokoyama, 1992, “Production of Monoclonal Antibodies” in Current Protocols in Immunology, Unit 2.5, Greene Publishing Assoc. and John Wiley &amp; Sons). Polyclonal sera and antibodies can be produced by inoculation of a mammalian subject with the relevant protein or fragments thereof in accordance with known methods. Fragments of antibodies, receptors, or other reactive peptides can be produced from the corresponding antibodies by cleavage of and collection of the desired fragments in accordance with known methods (see for example, Goding, supra; and Andrew et al., 1992, “Fragmentation of Immunoglobulins” in Current Protocols in Immunology, Unit 2.8, Greene Publishing Assoc. and John Wiley &amp; Sons). Chimeric antibodies and single chain antibodies can also be produced in accordance with known recombinant methods (see for example, U.S. Pat. Nos. 5,169,939, 5,194,594, and 5,576,184). Humanized antibodies can also be made from corresponding murine antibodies in accordance with well known methods (see for example, U.S. Pat. Nos. 5,530,101, 5,585,089, and 5,693,762). Additionally, human antibodies may be produced in non-human animals such as mice that have been genetically altered to express human antibody molecules (see for example Fishwild et al., 1996 , Nature Biotechnology  14: 845-851; Mendez et al., 1997 , Nature Genetics  15: 146-156 (erratum  Nature Genetics  16: 410); and U.S. Pat. Nos. 5,877,397 and 5,625,126). Such antibodies may be obtained using either the entire protein or fragments thereof as an immunogen. The peptide immunogens additionally may contain a cysteine residue at the carboxyl terminus, and are conjugated to a hapten such as keyhole limpet hemocyanin (KLH). Methods for synthesizing such peptides are known in the art, for example, as in R. P. Merrifield, J. Amer. Chem. Soc. 85, 2149-2154 (1963); J. L. Krstenansky, et al., FEBS Lett. 211, 10 (1987). 
     Monoclonal antibodies binding to the protein of the invention may be useful diagnostic agents for the immunodetection of the protein. Neutralizing monoclonal antibodies binding to the protein may also be useful therapeutics for both conditions associated with the protein and also in the treatment of some forms of cancer where abnormal expression of the protein is involved. In the case of cancerous cells or leukemic cells, neutralizing monoclonal antibodies against the protein may be useful in detecting and preventing the metastatic spread of the cancerous cells, which may be mediated by the protein. 
     For compositions of the present invention which are useful for bone, cartilage, tendon or ligament regeneration, the therapeutic method includes administering the composition topically, systematically, or locally as an implant or device. When administered, the therapeutic composition for use in this invention is, of course, in a pyrogen-free, physiologically acceptable form. Further, the composition may desirably be encapsulated or injected in a viscous form for delivery to the site of bone, cartilage or tissue damage. Topical administration may be suitable for wound healing and tissue repair. Therapeutically useful agents other than a protein of the invention which may also optionally be included in the composition as described above, may alternatively or additionally, be administered simultaneously or sequentially with the composition in the methods of the invention. Preferably for bone and/or cartilage formation, the composition would include a matrix capable of delivering the protein-containing composition to the site of bone and/or cartilage damage, providing a structure for the developing bone and cartilage and optimally capable of being resorbed into the body. Such matrices may be formed of materials presently in use for other implanted medical applications. 
     The choice of matrix material is based on biocompatibility, biodegradability, mechanical properties, cosmetic appearance and interface properties. The particular application of the compositions will define the appropriate formulation. Potential matrices for the compositions may be biodegradable and chemically defined calcium sulfate, tricalciumphosphate, hydroxyapatite, polylactic acid, polyglycolic acid and polyanhydrides. Other potential materials are biodegradable and biologically well-defined, such as bone or dermal collagen. Further matrices are comprised of pure proteins or extracellular matrix components. Other potential matrices are nonbiodegradable and chemically defined, such as sintered hydroxapatite, bioglass, aluminates, or other ceramics. Matrices may be comprised of combinations of any of the above mentioned types of material, such as polylactic acid and hydroxyapatite or collagen and tricalciumphosphate. The bioceramics may be altered in composition, such as in calcium-luminate-phosphate and processing to alter pore size, particle size, particle shape, and biodegradability. 
     Presently preferred is a 50:50 (mole weight) copolymer of lactic acid and glycolic acid in the form of porous particles having diameters ranging from 150 to 800 microns. In some applications, it will be useful to utilize a sequestering agent, such as carboxymethyl cellulose or autologous blood clot, to prevent the protein compositions from disassociating from the matrix. 
     A preferred family of sequestering agents is cellulosic materials such as alkylcelluloses (including hydroxyalkylcelluloses), including methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, and carboxymethylcellulose, the most preferred being cationic salts of carboxymethylcellulose (CMC). Other preferred sequestering agents include hyaluronic acid, sodium alginate, poly(ethylene glycol), polyoxyethylene oxide, carboxyvinyl polymer and poly(vinyl alcohol). The amount of sequestering agent useful herein is 0.5-20 wt %, preferably 1-10 wt % based on total formulation weight, which represents the amount necessary to prevent desorbtion of the protein from the polymer matrix and to provide appropriate handling of the composition, yet not so much that the progenitor cells are prevented from infiltrating the matrix, thereby providing the protein the opportunity to assist the osteogenic activity of the progenitor cells. 
     In further compositions, proteins of the invention may be combined with other agents beneficial to the treatment of the bone and/or cartilage defect, wound, or tissue in question. These agents include various growth factors such as epidermal growth factor (EGF), platelet derived growth factor (PDGF), transforming growth factors (TGF-α and TGF-β), and insulin-like growth factor (IGF). 
     The therapeutic compositions are also presently valuable for veterinary applications. Particularly domestic animals and thoroughbred horses, in addition to humans, are desired patients for such treatment with proteins of the present invention. 
     The dosage regimen of a protein-containing pharmaceutical composition to be used in tissue regeneration will be determined by the attending physician considering various factors which modify the action of the proteins, e.g., amount of tissue weight desired to be formed, the site of damage, the condition of the damaged tissue, the size of a wound, type of damaged tissue (e.g., bone), the patient&#39;s age, sex, and diet, the severity of any infection, time of administration and other clinical factors. The dosage may vary with the type of matrix used in the reconstitution and with inclusion of other proteins in the pharmaceutical composition. For example, the addition of other known growth factors, such as IGF I (insulin like growth factor I), to the final composition, may also effect the dosage. Progress can be monitored by periodic assessment of tissue/bone growth and/or repair, for example, X-rays, histomorphometric determinations and tetracycline labeling. 
     Polynucleotides of the present invention can also be used for gene therapy. Such polynucleotides can be introduced either in vivo or ex vivo into cells for expression in a mammalian subject. Polynucleotides of the invention may also be administered by other known methods for introduction of nucleic acid into a cell or organism (including, without limitation, in the form of viral vectors or naked DNA). 
     Cells may also be cultured ex vivo in the presence of proteins of the present invention in order to proliferate or to produce a desired effect on or activity in such cells. Treated cells can then be introduced in vivo for therapeutic purposes. 
     Patent and literature references cited herein are incorporated by reference as if fully set forth. 
     
       
         
           
               
            
               
                   
               
               
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                 Ile Leu Ser Thr Ile Phe Ile Ser Ser Phe Lys Gln Ile Leu Leu Val 
               
               
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                 Pro Met Trp Thr Phe Lys Asp Pro Leu Leu Asn Glu Met Ser Leu Ser 
               
               
                      50                  55                  60 
               
               
                   
               
               
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                              20                  25                  30 
               
               
                   
               
               
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                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 5 
               
               
                   
               
               
                 cacctgggac ctctcacagg tggcatgccc ttccaagacc aggagagaac accacaactt     60 
               
               
                   
               
               
                 tgcaggacca gcatctctca gcctgcctcc tccctttctc catatcaata tgatatggat    120 
               
               
                   
               
               
                 gagtactcat ccagcattgg atgatatgga tgaatggtca tccatcccag agcactgtcc    180 
               
               
                   
               
               
                 ctactccagt tccagggcac tcttagtctg ttcttggcac atacagcttt gcatctgtca    240 
               
               
                   
               
               
                 gtgtccatgc aaaagccaac acaagctgtg atggactgtg cattgggtag ccaccagagg    300 
               
               
                   
               
               
                 taactgccac ttatctatca gtcagccttt gacaggcctc acgtagatac gtacctccca    360 
               
               
                   
               
               
                 tcacctccaa gctggaatac actttactca tctgtaaaat gggtatgaac atgcctcctt    420 
               
               
                   
               
               
                 tgcagarctt ttttgaagat tctgcattta ctagtttaac aactgttcag tacctattat    480 
               
               
                   
               
               
                 gggcctagct accggcacat agtaaacact cagttacaat agctttaaga aaatctgtct    540 
               
               
                   
               
               
                 tagacaaagg agtttcaaaa ctatgtgaag agtatacaag aagtagtagt ccaaactgtt    600 
               
               
                   
               
               
                 ttttcagttg tttaatgatc tctatgataa agatgttcag ggagaggaat atcttgcgtg    660 
               
               
                   
               
               
                 ataactggag taaaacccac ttagatttct atgtccccaa acctctggtg tggtcagggt    720 
               
               
                   
               
               
                 tggcacctgc cctctcaacc atttgtctca ctgtacatgc atcttgtcta tgtcttccac    780 
               
               
                   
               
               
                 tagagaccat gagggcagag atcagaccta tgtacgttgc acattgctgt ccccagtacc    840 
               
               
                   
               
               
                 tagcacagca ccttgcccca gtacgcactt catatatatt tcctggacta cggcaggtga    900 
               
               
                   
               
               
                 gccctttgtg agggttccac ctgcccactg gcctggcctt taatgtcagg ggagcatttc    960 
               
               
                   
               
               
                 tgatatatta atgcccctct aattgtgctg cattcgttta cataggcagt gcagcagcct   1020 
               
               
                   
               
               
                 ggctttggtg tttaaagacc ggattgcagt caaagctctg ctgtttgctg gctatgaact   1080 
               
               
                   
               
               
                 ccaggtaagt tgccaggttc ctctgagcac taatgataat attacctgcc tcacagggtt   1140 
               
               
                   
               
               
                 gttttgagag cagcttctgc tgctgcccca tgccccagaa ttatggaaaa ccattttgta   1200 
               
               
                   
               
               
                 aacttcaagt cacttcctct ccatagtaca gatcaatggt agaccagtga tcagggagga   1260 
               
               
                   
               
               
                 tacaaatcat aaccccaaaa aaggcttctt tgttgtattt tacctcaagt gttttcttag   1320 
               
               
                   
               
               
                 agaacctcaa caaaccacac tattttctag taatcagcca cttatcccac catttgcagt   1380 
               
               
                   
               
               
                 aaggaaaact gaggcacgcc ttgatggctt attcagcatc agcagcctca caaaagacag   1440 
               
               
                   
               
               
                 aagtctcctt tggattagct ttatcatctt tcccttaagc agagatgatg gtgcctttct   1500 
               
               
                   
               
               
                 cgctgctctg gctcagttaa gaagtcaagt ctgatttatt ggtcatccta actatcgttt   1560 
               
               
                   
               
               
                 cctgaaggcc cgaagccctg taatgctgtt gtctggcttc ccagatttat gaccatggtt   1620 
               
               
                   
               
               
                 tctggccccc aacaatatct ggagttcggt ttacatattc acttccacca tccaatccaa   1680 
               
               
                   
               
               
                 atcctcccag gcagcaatca agctggggct gattcctcat ccatttgtgg gctcactttt   1740 
               
               
                   
               
               
                 tctggcaagt cagccttcat tctccaggac gcttagaagc cgcatgttgg cggtggattg   1800 
               
               
                   
               
               
                 tgctacggga aagagtgaat gtgtagcctg cacatttgaa gccttgctgg ggtagagagc   1860 
               
               
                   
               
               
                 aacgctactg ctcctggaat gtccaggcca ctgttagaaa ggccatctta ttccttagaa   1920 
               
               
                   
               
               
                 gagtctagcc ctgctgcagg cttcagaaac gtgtgctcta agctcgttcc tgctcatttg   1980 
               
               
                   
               
               
                 aagcagtctt ctgaaaaggt ctgcagaaac ctgcctttac cctctccctc atcctgcgtg   2040 
               
               
                   
               
               
                 gcctttgtca catccttcct ccaaggttcc tctggtggtg gtagtaggga ggctgccacc   2100 
               
               
                   
               
               
                 tggctttgca tgtgggaaag cccagcctct tccctccacc ctcacagcag gacagccaaa   2160 
               
               
                   
               
               
                 cttggatttt ttcatgagga agcaactctt atgagctctc tggttcagct ctctggttaa   2220 
               
               
                   
               
               
                 aagaccatac tgtgctgttt ctggggcagc acagacctgg ttgatcgtgt ccacaggaag   2280 
               
               
                   
               
               
                 aacagccttt gggattcatt agtctggtta agaccagccc tgcagcctcc tctgccagct   2340 
               
               
                   
               
               
                 atagaactat gtgttagagt tggtgctgaa gccagtcgca aacccatccc agatgcgtct   2400 
               
               
                   
               
               
                 ggtcttgttg atgttcaaat gccacctcct cctccaggaa gacttcacca cctccccaag   2460 
               
               
                   
               
               
                 gctgccttat gggctccttc tctgttccct ctcgactctc cccctctatc actatggcca   2520 
               
               
                   
               
               
                 ttttatagaa ttttaattat tgtctcgggt gtctccacta gactgtaagt atcaagtgtg   2580 
               
               
                   
               
               
                 tagagacttt tgtttcaact ctgtatcccc aaaattcagc atagttcata gcacatacag   2640 
               
               
                   
               
               
                 tactctcaat gcctgttgaa tgaataaaga gtctgcttgc atgtaaaact acagtggttt   2700 
               
               
                   
               
               
                 ggtcttggag acacttgttt tggaattctt ctactgatat ggacagcatc aagatgatgg   2760 
               
               
                   
               
               
                 gaaatgtatt ggtctgggat ttgttttgcc tacaaagttt cttatgttgg ctcatctcca   2820 
               
               
                   
               
               
                 actagataaa accctgagtc taggcttccc cttctaacaa agctgctata cctttatgga   2880 
               
               
                   
               
               
                 cctccatttt cctgtctgta aaatgagagt gtgggctagc tagaaaaatt tctggtgtcc   2940 
               
               
                   
               
               
                 cccttgctgc tttgtaattc tggagtacgt tcggagaaca ccccaatgtg acaaaggatc   3000 
               
               
                   
               
               
                 tggaaattct tcataaaata ttcagggagg gagacaactc agggaacatg acaactgtct   3060 
               
               
                   
               
               
                 ggaattattt gaggggttgt catgtagaag atgaaaagga ttagattatc ttgaaaggcc   3120 
               
               
                   
               
               
                 ccacaggtta taaataagac caattattaa ttcattcaac aaatatttga gtacctgcca   3180 
               
               
                   
               
               
                 tgtgcaaggc actattctaa gcaataatga tgcagtaatg aatacaacag acaaaaatct   3240 
               
               
                   
               
               
                 tgttgccttt atggagttga cattctagtg aacagaaaca attcaaaaac aaacacaatg   3300 
               
               
                   
               
               
                 gagaggagct tcttggaccc tcaaaacgag ctgcctgtga actattgagc tctttgtgtt   3360 
               
               
                   
               
               
                 caggaatacg tttagtactt agaaatctgc ttccagtggc tgcttagact aaatgacctt   3420 
               
               
                   
               
               
                 gttaggtttt tttagcccag caatcccatg aatctaaggc tagcgaagat gtgtgatctc   3480 
               
               
                   
               
               
                 tctattctaa caccactaag ccaaatcatg acctcctctc aatggtaact gtcactctaa   3540 
               
               
                   
               
               
                 aaagagagat aaggtagatg cagtgggctg ttcttatgaa aaggcaccta aaaaatagta   3600 
               
               
                   
               
               
                 ctttagaaac atgcattgtg gtgggggtct gggtggaggg gttgcttttt cttgagatcc   3660 
               
               
                   
               
               
                 ctgtgatatt gaggatgaag aaagagaaac acagggggtg ggcaacttcc ttgaaggacc   3720 
               
               
                   
               
               
                 agagagagtg agtcatgagg aagagaagga ggagacagag aacaggagag ttggggatga   3780 
               
               
                   
               
               
                 agcctttgat gaggggagtg aggaggggca gaagtaggag acagacatga ggaaaccacc   3840 
               
               
                   
               
               
                 aactgaagtc ccagaaaccc agcctccgtc ccctctaggt cctactgccg tcatcctctt   3900 
               
               
                   
               
               
                 tctgtaaagg tgagagtcta ggtgcagtgt cccaggttcc aaacacaagt tcatactcat   3960 
               
               
                   
               
               
                 tgactagtgg gatgcccact gtgagagcag gaaggagggc tagagagatc taagagggca   4020 
               
               
                   
               
               
                 gaagccctgc cctgccagta ttttttgcct ccagccacct gctctgttct gagacatgcc   4080 
               
               
                   
               
               
                 tgagaccagc tgcctacagg gggaccaggg tctgtttctg ctgttaacct tggttccctc   4140 
               
               
                   
               
               
                 ctgcattcct gcatgtgggg atgtagacag gaagcctgca ggtatggagc aattgaagca   4200 
               
               
                   
               
               
                 gagtctagat agagcccaga ctccttactt cccatagtac tattctgcat tttgtagtgc   4260 
               
               
                   
               
               
                 tgcttatgct tttcagtgtt tccacatcta tttactaata acatcatagt acaacagcaa   4320 
               
               
                   
               
               
                 gaacatggcc tcagaactca aagttctgga attctaatat tttatttgat tgtcagtatt   4380 
               
               
                   
               
               
                 tctgtgagat agataaaata ggaattattt cctctgatct gcaggtgagg aaactcagtc   4440 
               
               
                   
               
               
                 acagggagca catttatcca tacttgtgga gctatagtat aactagtatt aggacaagga   4500 
               
               
                   
               
               
                 tagccaacat agttaaaaaa aaaaaaaaa                                     4529 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 6 
               
               
                 &lt;211&gt; LENGTH: 98 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 6 
               
               
                   
               
               
                 Met Ile Ser Met Ile Lys Met Phe Arg Glu Arg Asn Ile Leu Arg Asp 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Asn Trp Ser Lys Thr His Leu Asp Phe Tyr Val Pro Lys Pro Leu Val 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Trp Ser Gly Leu Ala Pro Ala Leu Ser Thr Ile Cys Leu Thr Val His 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ala Ser Cys Leu Cys Leu Pro Leu Glu Thr Met Arg Ala Glu Ile Arg 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Pro Met Tyr Val Ala His Cys Cys Pro Gln Tyr Leu Ala Gln His Leu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ala Pro Val Arg Thr Ser Tyr Ile Phe Pro Gly Leu Arg Gln Val Ser 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Pro Leu 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 7 
               
               
                 &lt;211&gt; LENGTH: 3537 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 7 
               
               
                   
               
               
                 aacttagatt tcttaaaact gtatacagat aactaatttt tattttgaaa tagcttttat     60 
               
               
                   
               
               
                 gttcttgtgt ttatgtaata gtcacattaa ttttgctctt ttggctttgt gttgtgttta    120 
               
               
                   
               
               
                 tttgatgact gttttattcg gtttaatttt ttcttgattt tgcaaattca tttttatcat    180 
               
               
                   
               
               
                 ctttaagtgg tggagtggcc atttcagctt gaaatatttc actgtcttta taatttcatt    240 
               
               
                   
               
               
                 ccatgcatgt gttttgtgtt tgtgacggtg tggtggtatt tagtctatag aagaacatgt    300 
               
               
                   
               
               
                 ggagcaggtc aaccaaaact gcatagcaga agattgccac atcaaggtag tattccaaga    360 
               
               
                   
               
               
                 tcttgtattt agctcattct ttaaagttca aggagctaac gcctcatctc tgatactaac    420 
               
               
                   
               
               
                 catgacctgc ccaactggct aactactcag agaactcata gtactcccat accacttcag    480 
               
               
                   
               
               
                 tggcacaggg gaggagatgc ttcactgtat ctggcttgct ctgtcttgcc cttggttctt    540 
               
               
                   
               
               
                 ctctttcttg ctccctgtcc catcttcact tgtcactttt tctgttttaa gcatggctgt    600 
               
               
                   
               
               
                 ttcatcttct tgattctgcc ttttctttcc ttcccatcac caaccctaag ccattgcatc    660 
               
               
                   
               
               
                 ttcctctcat cagtctcttt tattcctttc gaagtatccc tctttccaac ttttccttat    720 
               
               
                   
               
               
                 ttctgtctca ccacccttac ttcaaagggt ggtttctttg cggttttcta tggcttttta    780 
               
               
                   
               
               
                 ctccactctg tgcctcttaa tgtatacaca ttcttattgc agaatattta tgcacttttg    840 
               
               
                   
               
               
                 gaagagctaa gagagacata ctactgtata aattactaat aaaaatatat tagccatgtt    900 
               
               
                   
               
               
                 ttataattaa tcagtatctt accatcacag tggaaattgg ggtgattaca ggacatcaga    960 
               
               
                   
               
               
                 gaatttaagc aaattttcca aagctagttt tcaacacatt aaagttactc ttaccctttt   1020 
               
               
                   
               
               
                 ttcttgctgc tgctgctgct gctacatttt cttcttatcc tacatttaaa tcttatggga   1080 
               
               
                   
               
               
                 tgtgcataac tctaaataga gctgtgctgc agcaactaaa actgctgatg aatgttttct   1140 
               
               
                   
               
               
                 aggttgaagc tgatctgggc tatccaggtg gaaaggcgaa agtcatccat aaggaatctg   1200 
               
               
                   
               
               
                 atatgatcat ggcattttct gttaataagg caaattgtaa tgaaattgtt ttggcttcaa   1260 
               
               
                   
               
               
                 cacatgatgt tcaagaactt gatgttactt ctctactggc ctgtcagtca tacatatgga   1320 
               
               
                   
               
               
                 tcggagaaga atatgacaga gaatccaaaa gttcagatga tgttgattat cgtggttcca   1380 
               
               
                   
               
               
                 ctacaactct ttatcaaccc agtgcaacat cctattcagc aagtcaggtg catccacctt   1440 
               
               
                   
               
               
                 catctctgcc atggctgggc actggacaga ctagcactgg agctagtgtg cttatgaaaa   1500 
               
               
                   
               
               
                 ggaatctaca taatgttaag agaatgactt cacacccagt ccatcaatac tatcttacag   1560 
               
               
                   
               
               
                 gtgctcagga cggcagtgta cgaatgtttg aatggacgcg gcctcagcaa cttgtctgct   1620 
               
               
                   
               
               
                 ttcgtcaagc tggcaatgca agagttacta gattatattt taattcacaa ggcaacaagt   1680 
               
               
                   
               
               
                 gtggtgttgc ggatggagag ggttttctga gtatctggca agttaaccaa actgcatcaa   1740 
               
               
                   
               
               
                 atcctaaacc ttatatgagt tggcagtgcc acagtaaagc cacaagtgac tttgcattta   1800 
               
               
                   
               
               
                 ttacctcttc aagtctagtt gccacatctg gacactccaa tgacaataga aatgtttgcc   1860 
               
               
                   
               
               
                 tctgggacac attaatatca cccggaaaca gcctcattca tggtttcacg tgccacgatc   1920 
               
               
                   
               
               
                 atggtgccac ggtactgcag tatgcaccca aacagcaact cctaatctcg gggggtagga   1980 
               
               
                   
               
               
                 aaggacacgt ctgcattttt gacatcaggc aaaggcagct cattcacacg ttccaggccc   2040 
               
               
                   
               
               
                 atgactcagc tattaaggct ctggccttgg atccctatga ggaatatttt accacaggtt   2100 
               
               
                   
               
               
                 cagcagaagg taacataaag gtttggagat tgacaggcca tggcctaatt cattcattta   2160 
               
               
                   
               
               
                 aaagtgaaca tgctaagcag tccatatttc gaaacattgg ggctggagtc atgcagattg   2220 
               
               
                   
               
               
                 acatcatcca gggcaatcgg ctcttctcct gtggtgcaga tggcacgctg aaaaccaggg   2280 
               
               
                   
               
               
                 ttttgcccaa tgcttttaac atccctaaca gaattcttga cattctataa agattggggt   2340 
               
               
                   
               
               
                 tttattttta tatacatttc agttaaaagg cacactacag tcatcactag gcaattctgc   2400 
               
               
                   
               
               
                 tttctaagca gttgtattga aaacagagaa tctctgtgta gaatttgaat atgacccaag   2460 
               
               
                   
               
               
                 ctgagtatta tctaaacagg ttggtggaat gaatgcgcat gtaccttatt atgctgacat   2520 
               
               
                   
               
               
                 actaaaaaaa ataaaaccta gtattgtatg aaggatagct attctttaca gcatttagca   2580 
               
               
                   
               
               
                 aacctgattc agaaaacatt tgagattagc aaattagtaa cttgaaataa tgaaaaggac   2640 
               
               
                   
               
               
                 gtttatacca aattaaggaa gaaaatgttg ctgatttggg tttttcttcc tgttcttacc   2700 
               
               
                   
               
               
                 actgactgaa gcatgcctgc agtctcctcc tctgttgaat gaaggataat cataaggtgt   2760 
               
               
                   
               
               
                 ttgttaggag cgctagacca cctggaaaac tttcttagct gtggagcagt gcgcagtgac   2820 
               
               
                   
               
               
                 cagttctctg ctgtgagagg ccgtttccat tctttcctgc tgaatatttt tcctgttagt   2880 
               
               
                   
               
               
                 gtttatactg agctagtact gtaacttgca aatgagtgca aatttaaatg caatgtttta   2940 
               
               
                   
               
               
                 ctcacaattt gcacattcac attttttgga ctgctagttt ttctatttaa atatttgcct   3000 
               
               
                   
               
               
                 tcatgttagg aatgtactat gtgaacatga catatttgta gttaaccaaa cacaccttct   3060 
               
               
                   
               
               
                 tagtccagtt tagtactttt tcttttcgtg tattcaaggt taaacaccca aacatttaag   3120 
               
               
                   
               
               
                 gatatgttga aactacacca atagagcatt tcatatcata attaaaatga atgttaggct   3180 
               
               
                   
               
               
                 tcttgtggcc agttaatagt tgatgagatt ggtgacatta tttattgcca cagcctattg   3240 
               
               
                   
               
               
                 tataaactat gcagagttaa atatttgctt gtaaaatatt agccaatgtt gtcattattt   3300 
               
               
                   
               
               
                 tgatgtattt ccttggttat gaccaaaaat atgttgagat actgaaacta atgtctgtgt   3360 
               
               
                   
               
               
                 gtttaaatgt ttaccagcaa attgtcttat catgttaatg agaatgttca atgcctgtgt   3420 
               
               
                   
               
               
                 ggtaaatagt aaatacaatg gcataaaagt aactttctct gaagatgtga tgttcaggct   3480 
               
               
                   
               
               
                 gtgaaatata tatgtaaaag aaaaataaat gttatttgtt agaaaaaaaa aaaaaaa      3537 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 8 
               
               
                 &lt;211&gt; LENGTH: 375 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 8 
               
               
                   
               
               
                 Met Ile Met Ala Phe Ser Val Asn Lys Ala Asn Cys Asn Glu Ile Val 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Leu Ala Ser Thr His Asp Val Gln Glu Leu Asp Val Thr Ser Leu Leu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ala Cys Gln Ser Tyr Ile Trp Ile Gly Glu Glu Tyr Asp Arg Glu Ser 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Lys Ser Ser Asp Asp Val Asp Tyr Arg Gly Ser Thr Thr Thr Leu Tyr 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gln Pro Ser Ala Thr Ser Tyr Ser Ala Ser Gln Val His Pro Pro Ser 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ser Leu Pro Trp Leu Gly Thr Gly Gln Thr Ser Thr Gly Ala Ser Val 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Leu Met Lys Arg Asn Leu His Asn Val Lys Arg Met Thr Ser His Pro 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Val His Gln Tyr Tyr Leu Thr Gly Ala Gln Asp Gly Ser Val Arg Met 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Phe Glu Trp Thr Arg Pro Gln Gln Leu Val Cys Phe Arg Gln Ala Gly 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Asn Ala Arg Val Thr Arg Leu Tyr Phe Asn Ser Gln Gly Asn Lys Cys 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Gly Val Ala Asp Gly Glu Gly Phe Leu Ser Ile Trp Gln Val Asn Gln 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Thr Ala Ser Asn Pro Lys Pro Tyr Met Ser Trp Gln Cys His Ser Lys 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Ala Thr Ser Asp Phe Ala Phe Ile Thr Ser Ser Ser Leu Val Ala Thr 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Ser Gly His Ser Asn Asp Asn Arg Asn Val Cys Leu Trp Asp Thr Leu 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Ile Ser Pro Gly Asn Ser Leu Ile His Gly Phe Thr Cys His Asp His 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Gly Ala Thr Val Leu Gln Tyr Ala Pro Lys Gln Gln Leu Leu Ile Ser 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Gly Gly Arg Lys Gly His Val Cys Ile Phe Asp Ile Arg Gln Arg Gln 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Leu Ile His Thr Phe Gln Ala His Asp Ser Ala Ile Lys Ala Leu Ala 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Leu Asp Pro Tyr Glu Glu Tyr Phe Thr Thr Gly Ser Ala Glu Gly Asn 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Ile Lys Val Trp Arg Leu Thr Gly His Gly Leu Ile His Ser Phe Lys 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Ser Glu His Ala Lys Gln Ser Ile Phe Arg Asn Ile Gly Ala Gly Val 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Met Gln Ile Asp Ile Ile Gln Gly Asn Arg Leu Phe Ser Cys Gly Ala 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Asp Gly Thr Leu Lys Thr Arg Val Leu Pro Asn Ala Phe Asn Ile Pro 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 Asn Arg Ile Leu Asp Ile Leu 
               
               
                     370                 375 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 9 
               
               
                 &lt;211&gt; LENGTH: 1466 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 9 
               
               
                   
               
               
                 ccgcgcagga ggacggagcc ctaaccgcaa cccgcgccgc gccgcgccga tttgatttgt     60 
               
               
                   
               
               
                 atccactgtc accagcactg ctcacttagg actttctgga tccggaccca ggcagcgcac    120 
               
               
                   
               
               
                 actggactct tgaggaagaa ggagactcta attttggatt ccttggtgga ggaaaataaa    180 
               
               
                   
               
               
                 acactctggt cttgccgcca acgatgcaag tgtgactgct ggcgtcttca tgagctccag    240 
               
               
                   
               
               
                 aggtcacagc acgctaccaa ggactctcat ggcccctcgg atgatttccg agggagacat    300 
               
               
                   
               
               
                 argaggcatt gctcaaatca cctcctctct attcctgggc agaggcagtg tggcctccaa    360 
               
               
                   
               
               
                 tcggcacctc ctccaggctc gtggcatcac ctgcattgtt aatgctacca ttgagatccc    420 
               
               
                   
               
               
                 taatttcaac tggccccaat ttgagtatgt taaagtgcct ctggctgaca tgccgcatgc    480 
               
               
                   
               
               
                 ccccattgga ctgtactttg acaccgtggc tgacaagatc cacagtgtga gcaggaagca    540 
               
               
                   
               
               
                 cggggccacc ttggtgcact gtgctgcagg ggtgagccgc tcagccacgc tgtgtatcgc    600 
               
               
                   
               
               
                 gtacctgatg aaattccaca acgtgtgcct gctggaggcg tacaactggg tgaaagcccg    660 
               
               
                   
               
               
                 gcgacctgtc atcaggccca acgtaggctt ctggaggcaa ctgatagact acgagcgcca    720 
               
               
                   
               
               
                 gctctttggg aagtcgacag ttaaaatggt acagacacct tatggcatag ttcccgacgt    780 
               
               
                   
               
               
                 ctatgagaag gagtcccgac acctgatgcc ttactggggg atttagtgcc actgaagcct    840 
               
               
                   
               
               
                 gcgtcagcag cccgagcggg gccggcatct gctccccgcc gtctgctccc tctccactct    900 
               
               
                   
               
               
                 cttctcaaat ggctgacttc tggttctccc tcaagtgttt tttacactgg gtgttcaaat    960 
               
               
                   
               
               
                 ttattttaag agatagggag ggaggggaca taaagggaat gcatacattg ctagtcacat   1020 
               
               
                   
               
               
                 ttttaaaatt aacattttgg aatagtgttt atggaaatct ttagctttta atcattttta   1080 
               
               
                   
               
               
                 ccaatttgaa cagtttaata aactggttct gctctcttct gaatctcakg ccttkggcac   1140 
               
               
                   
               
               
                 cttggtaggt gcaggaggag ctcagtgcaa aaatcacttt ggggcctcat taacccttta   1200 
               
               
                   
               
               
                 gagacaagyt ttgccccagg ytgcggacca gacagatgyt tagggaaggt tgataccagc   1260 
               
               
                   
               
               
                 ttcagtctct astggattag ccctactctt tcctttcccc tccattattt agtgactctg   1320 
               
               
                   
               
               
                 taagtaagtt aaatacaccc ttattattta gctgttaagt aactataatg aaatctgctg   1380 
               
               
                   
               
               
                 caaaatctct cttggaatcc atgtgcccag gattatatta gcattatttt taataaatct   1440 
               
               
                   
               
               
                 atatgcttaa caaaaaaaaa aaaaaa                                        1466 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 10 
               
               
                 &lt;211&gt; LENGTH: 198 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: UNSURE 
               
               
                 &lt;222&gt; LOCATION: (25) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 10 
               
               
                   
               
               
                 Met Ser Ser Arg Gly His Ser Thr Leu Pro Arg Thr Leu Met Ala Pro 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Arg Met Ile Ser Glu Gly Asp Ile Xaa Gly Ile Ala Gln Ile Thr Ser 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ser Leu Phe Leu Gly Arg Gly Ser Val Ala Ser Asn Arg His Leu Leu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gln Ala Arg Gly Ile Thr Cys Ile Val Asn Ala Thr Ile Glu Ile Pro 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Asn Phe Asn Trp Pro Gln Phe Glu Tyr Val Lys Val Pro Leu Ala Asp 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Met Pro His Ala Pro Ile Gly Leu Tyr Phe Asp Thr Val Ala Asp Lys 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ile His Ser Val Ser Arg Lys His Gly Ala Thr Leu Val His Cys Ala 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ala Gly Val Ser Arg Ser Ala Thr Leu Cys Ile Ala Tyr Leu Met Lys 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Phe His Asn Val Cys Leu Leu Glu Ala Tyr Asn Trp Val Lys Ala Arg 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Arg Pro Val Ile Arg Pro Asn Val Gly Phe Trp Arg Gln Leu Ile Asp 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Tyr Glu Arg Gln Leu Phe Gly Lys Ser Thr Val Lys Met Val Gln Thr 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Pro Tyr Gly Ile Val Pro Asp Val Tyr Glu Lys Glu Ser Arg His Leu 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Met Pro Tyr Trp Gly Ile 
               
               
                         195 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 11 
               
               
                 &lt;211&gt; LENGTH: 1521 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 11 
               
               
                   
               
               
                 aatttcttgg gcatttaccc atgccagaag gctaacctgg ggggaggggg gcgcttgtgc     60 
               
               
                   
               
               
                 tggtgaggca cttggataca tactgatgct gcaagttcag gggatttttc ttactcttag    120 
               
               
                   
               
               
                 gtttaaccaa gaacactgag cagggaaaaa ccctgccttt cctaactgca tgtatttttt    180 
               
               
                   
               
               
                 cctttttgga aaggtggtag agactcagaa gctttccttg ttttcttcag gcctgctccc    240 
               
               
                   
               
               
                 agttttctta acagtttctt ttgttgcttt ctctctccct tgttgctttc catggcagta    300 
               
               
                   
               
               
                 atcctcctag agtccaagca gtctgttgta tggagcaggg tgtgtgggtt ttctgggccc    360 
               
               
                   
               
               
                 atcattatgg ctgcttcaga gtcagaagaa agccataggg cagtagggga gctcctattg    420 
               
               
                   
               
               
                 cctarcccct ctccctttgt ggctcccact ctagctgcct atttttgctc atcagctggt    480 
               
               
                   
               
               
                 gagtcagtat gggccagcag ttctccctcc ctaagccctt gctactttat gggttagctt    540 
               
               
                   
               
               
                 tgcaggtttg gtggcttgag gggtgggggc aactcaccac tgccaggtaa ctccctgaag    600 
               
               
                   
               
               
                 ggtgggagtg gattatcttc taggctctta cccgcggtag ggaagggcat caacactgtc    660 
               
               
                   
               
               
                 ttccttccat tctcctttcc cccatcccat ttagtgctgc cacagggcag aagcacacaa    720 
               
               
                   
               
               
                 accaaccaca cagtctctga cttctcctaa gcactttgag ttgttgaatg gggctcaggg    780 
               
               
                   
               
               
                 gcaagagttt ttgctgccct ccccagcgtg gtcacagggt tattgaactg cctgcacttg    840 
               
               
                   
               
               
                 tttctcatgc aactccagca ttttccccag aagttgaact atggatagca gcttggtatg    900 
               
               
                   
               
               
                 gatttcctaa atcttaacat ttgaagcagc ttcttgaggc tggcaactat cctggtttct    960 
               
               
                   
               
               
                 gtcttggagg gggtggtttg tttgctgggg cccaacgtct gtcccaagtg gtggggtgag   1020 
               
               
                   
               
               
                 agtaagttaa ctttggtgcc aggtgagagg tgggggctct ttgcttagac tccctatcat   1080 
               
               
                   
               
               
                 ggaaagattg gagttttcta tgcagggcac tggggaaaag gattgctgat tctgactgac   1140 
               
               
                   
               
               
                 cctgatcaga gagattagga ttgtattttg acataggatt tggaacccat ctaaatgttg   1200 
               
               
                   
               
               
                 aagttccctg agacrgctct ccagctgctg agcctgcgcc aggggytaag cagcccctaa   1260 
               
               
                   
               
               
                 tgagaggctc tgctcccttt cccacctcgc caatgttgtt gttgctgcct ttttgatttg   1320 
               
               
                   
               
               
                 tatcctctgt tatagacatt ttttraaaac gatttcctct ttcattgtgc acaagtgctg   1380 
               
               
                   
               
               
                 agagtctgag gccccatttc tgctgtgtat atatatcctg actcggggct tttattcagc   1440 
               
               
                   
               
               
                 aaactgttca ttcttctgtc agacaatgtc atattcaact ctgttcatat taaaccactg   1500 
               
               
                   
               
               
                 tgaagcaaaa aaaaaaaaaa a                                             1521 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 12 
               
               
                 &lt;211&gt; LENGTH: 81 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: UNSURE 
               
               
                 &lt;222&gt; LOCATION: (45) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 12 
               
               
                   
               
               
                 Met Ala Val Ile Leu Leu Glu Ser Lys Gln Ser Val Val Trp Ser Arg 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Val Cys Gly Phe Ser Gly Pro Ile Ile Met Ala Ala Ser Glu Ser Glu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Glu Ser His Arg Ala Val Gly Glu Leu Leu Leu Pro Xaa Pro Ser Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Phe Val Ala Pro Thr Leu Ala Ala Tyr Phe Cys Ser Ser Ala Gly Glu 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ser Val Trp Ala Ser Ser Ser Pro Ser Leu Ser Pro Cys Tyr Phe Met 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 13 
               
               
                 &lt;211&gt; LENGTH: 697 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 13 
               
               
                   
               
               
                 tgaagcttct gcacatgtag ttcctagagc tgctgcttat taaaatgtca acatcttcat     60 
               
               
                   
               
               
                 cttctagctg ggacaacctc ttagagtctc tctctctcag cacagtatgg aattggatac    120 
               
               
                   
               
               
                 aagcaagttt tttgggagag actagtgcac ctcagcaaac aagtttggga ctattatata    180 
               
               
                   
               
               
                 atcttgctcc agctgtgcaa atcatcttga ggatttcttt cttgatttta ttgggaatag    240 
               
               
                   
               
               
                 gaatatatgc cttatggaaa cgaagtattc agtcaattca gaaaacattg ttgtttgtaa    300 
               
               
                   
               
               
                 tcacactcta caaactttac aagaagggct cacatatttt tgaggctttg ctagccaacc    360 
               
               
                   
               
               
                 cagaaggaag tggtctccga attcaagaca ataataatct tttcctgtcc ttgggtctgc    420 
               
               
                   
               
               
                 aagagaaaat tttgaaaaaa cttaagacag tggaaaacaa aatgaagaac ctagaaggga    480 
               
               
                   
               
               
                 taatcgttgc tcaaaaacct gccacgaaga gggattgctc ctctgagccc tactgcagct    540 
               
               
                   
               
               
                 gctctgactg ccagagtccc ttgtccacat cagggtttac ttcccccatt tgaaatgtga    600 
               
               
                   
               
               
                 tggactccaa tcttttccag gaaagcactg tttccctcat gtgtgcagtg gtgtatcaat    660 
               
               
                   
               
               
                 aaagatagag aacgctattg aaaaaaaaaa aaaaaaa                             697 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 14 
               
               
                 &lt;211&gt; LENGTH: 182 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 14 
               
               
                   
               
               
                 Met Ser Thr Ser Ser Ser Ser Ser Trp Asp Asn Leu Leu Glu Ser Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ser Leu Ser Thr Val Trp Asn Trp Ile Gln Ala Ser Phe Leu Gly Glu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Thr Ser Ala Pro Gln Gln Thr Ser Leu Gly Leu Leu Tyr Asn Leu Ala 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Pro Ala Val Gln Ile Ile Leu Arg Ile Ser Phe Leu Ile Leu Leu Gly 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ile Gly Ile Tyr Ala Leu Trp Lys Arg Ser Ile Gln Ser Ile Gln Lys 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Thr Leu Leu Phe Val Ile Thr Leu Tyr Lys Leu Tyr Lys Lys Gly Ser 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 His Ile Phe Glu Ala Leu Leu Ala Asn Pro Glu Gly Ser Gly Leu Arg 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ile Gln Asp Asn Asn Asn Leu Phe Leu Ser Leu Gly Leu Gln Glu Lys 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Ile Leu Lys Lys Leu Lys Thr Val Glu Asn Lys Met Lys Asn Leu Glu 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Gly Ile Ile Val Ala Gln Lys Pro Ala Thr Lys Arg Asp Cys Ser Ser 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Glu Pro Tyr Cys Ser Cys Ser Asp Cys Gln Ser Pro Leu Ser Thr Ser 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Gly Phe Thr Ser Pro Ile 
               
               
                             180 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 15 
               
               
                 &lt;211&gt; LENGTH: 983 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 15 
               
               
                   
               
               
                 gggcgtggtg tcttgctgtc tcaggccctt cctctgtgca tccacgtaag tgtgggtaag     60 
               
               
                   
               
               
                 ccaagaatag cctgggttca aatccacctt tgccgttaat tggctgtgtg ctggtagaca    120 
               
               
                   
               
               
                 agttacttag cttctctgtg cccccactcc ctcatctgca cgcgagaatt gtaacagagc    180 
               
               
                   
               
               
                 cttcctcaga gcgatgatgg tgtttaggat gacatgcgct gcacagcaag tcctggccgt    240 
               
               
                   
               
               
                 ggcggctgcc attgcagccc gtggggtcac cctggaggcc gtgattgctg atgttgtgct    300 
               
               
                   
               
               
                 gttcttgtgc cttgctctct tcttctcggt gcccccagac tctctctgcc ttcggaggac    360 
               
               
                   
               
               
                 ggcgtctctc tcgcctcaca ctgtgtgcac gggcagtgcg gacgggtgct ggcttggtct    420 
               
               
                   
               
               
                 ttccagccct gcctcgctcg gggcctgctg catcgtagct caggcctagg acccatctct    480 
               
               
                   
               
               
                 gtacctgcag gtcttgggtg ctgcccggca tgagtggagg agtttatcag aacaggacct    540 
               
               
                   
               
               
                 tttataggag gttttaactt tagaagggaa tagaaaagtg tcatggcagc aatatttatt    600 
               
               
                   
               
               
                 tctagatcac cctgagtttt ttttctttgt ttkgtttwat tgtcctcttt acaccatgag    660 
               
               
                   
               
               
                 tttttaatga tgaatgagtg aaggagtgac agtgcgggtt gagcatccct tatccagatg    720 
               
               
                   
               
               
                 ctccagaatc ggaaaccctc tgacaccgat gtggcacctc aggcatagct gagctagtga    780 
               
               
                   
               
               
                 cacctttgct ttctcatggg tcagtgtaca caaaccttgt ttcatgcaca aaattatcaa    840 
               
               
                   
               
               
                 aagtaccgca caaaattacc ctcaggctgt gtgtataagg tgtatatgaa acataaatga    900 
               
               
                   
               
               
                 atttcctgtt cagacctggg tcctatccaa acatatctca ttacgtatat acagatgttc    960 
               
               
                   
               
               
                 cgaatcagaa aaaaaaaaaa aaa                                            983 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 16 
               
               
                 &lt;211&gt; LENGTH: 91 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 16 
               
               
                   
               
               
                 Met Met Val Phe Arg Met Thr Cys Ala Ala Gln Gln Val Leu Ala Val 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ala Ala Ala Ile Ala Ala Arg Gly Val Thr Leu Glu Ala Val Ile Ala 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Asp Val Val Leu Phe Leu Cys Leu Ala Leu Phe Phe Ser Val Pro Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Asp Ser Leu Cys Leu Arg Arg Thr Ala Ser Leu Ser Pro His Thr Val 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Cys Thr Gly Ser Ala Asp Gly Cys Trp Leu Gly Leu Ser Ser Pro Ala 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ser Leu Gly Ala Cys Cys Ile Val Ala Gln Ala 
               
               
                                  85                  90 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 17 
               
               
                 &lt;211&gt; LENGTH: 267 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 17 
               
               
                   
               
               
                 ggaaaacacc ctaaatgtgc atgcatctcc aagtcctcca ggagccacgc gtgctccaca     60 
               
               
                   
               
               
                 ttctttcttt tcctggcaca tttttggctg ccaggatgac tgagaaaata atcaaccttc    120 
               
               
                   
               
               
                 ccatcagtca cctgtttctc ttcctgagca gtttccttct gccactcagt caaaaggccc    180 
               
               
                   
               
               
                 acaaacatgt tcaccaagtc ctaacctcta gaagggagag agacttcaga gactgatttt    240 
               
               
                   
               
               
                 tagctgcaac caaaaaaaaa aaaaaaa                                        267 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 18 
               
               
                 &lt;211&gt; LENGTH: 73 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 18 
               
               
                   
               
               
                 Met Cys Met His Leu Gln Val Leu Gln Glu Pro Arg Val Leu His Ile 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Leu Ser Phe Pro Gly Thr Phe Leu Ala Ala Arg Met Thr Glu Lys Ile 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ile Asn Leu Pro Ile Ser His Leu Phe Leu Phe Leu Ser Ser Phe Leu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Pro Leu Ser Gln Lys Ala His Lys His Val His Gln Val Leu Thr 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ser Arg Arg Glu Arg Asp Phe Arg Asp 
               
               
                  65                  70 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 19 
               
               
                 &lt;211&gt; LENGTH: 679 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 19 
               
               
                   
               
               
                 aaacttctgg gatcacaggc atgagccacc gtgcctggcc ctgatctggg atttaaaggg     60 
               
               
                   
               
               
                 gcagttgctg agcaaataga agccagggca agaaaggatt tatgtgcttg ggattcttga    120 
               
               
                   
               
               
                 ggggttttcc agagtcagtc cccaattctg atgtttttat acgcaacact aggggtcctt    180 
               
               
                   
               
               
                 ctgaagttat cccggcccct gggaaactca cgtggcatgg ggcccccttc tgccctggtc    240 
               
               
                   
               
               
                 tctttcatcc catctgtccc ggccccagag cctgtccagt ctggtcctct ctgtcctgct    300 
               
               
                   
               
               
                 tggtttgtca ccatgtgatg ttgggatggc ttgtctttgc cgcctcactt cctaagctga    360 
               
               
                   
               
               
                 cagacgtgtc tgctagggac caccagctcc caagccgcat gacggtgctt tccttcaagg    420 
               
               
                   
               
               
                 ttcagaggct tccctttcag tctggcccat ctcccacatc ctaatggctc tgctgtctca    480 
               
               
                   
               
               
                 ggggcagctc tcctttttaa cttattggca gagctgggat gacttatagg tccctggctc    540 
               
               
                   
               
               
                 agtgagtaag caagttcaga gacttggctt tggccatttt gttctcttag gctcatcctt    600 
               
               
                   
               
               
                 ggatgccaac agggaaataa cctgccagat ttcagtcact actttttaga agttaaaaaa    660 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaa                                                 679 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 20 
               
               
                 &lt;211&gt; LENGTH: 120 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 20 
               
               
                   
               
               
                 Met Cys Leu Gly Phe Leu Arg Gly Phe Pro Glu Ser Val Pro Asn Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Asp Val Phe Ile Arg Asn Thr Arg Gly Pro Ser Glu Val Ile Pro Ala 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Pro Gly Lys Leu Thr Trp His Gly Ala Pro Phe Cys Pro Gly Leu Phe 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 His Pro Ile Cys Pro Gly Pro Arg Ala Cys Pro Val Trp Ser Ser Leu 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ser Cys Leu Val Cys His His Val Met Leu Gly Trp Leu Val Phe Ala 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ala Ser Leu Pro Lys Leu Thr Asp Val Ser Ala Arg Asp His Gln Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Pro Ser Arg Met Thr Val Leu Ser Phe Lys Val Gln Arg Leu Pro Phe 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Gln Ser Gly Pro Ser Pro Thr Ser 
               
               
                         115                 120 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 21 
               
               
                 &lt;211&gt; LENGTH: 3340 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 21 
               
               
                   
               
               
                 ggaggaacac ggcaacttcc ttattacagt tcctggaggg tcagatggtc caagtggagt     60 
               
               
                   
               
               
                 actgatctgc tctgaaaact atattactta caagaacttt ggtgaccagc cagatatccg    120 
               
               
                   
               
               
                 ctgtccaatt cccaggaggc ggaatgacct ggatgaccct gaaagaggaa tgatttttgt    180 
               
               
                   
               
               
                 ctgctctgca acccataaaa ccaaatcgat gttcttcttt ttggctcaaa ctgagcaggg    240 
               
               
                   
               
               
                 agatatcttt aagatcactt tggagacaga tgaagatatg gttactgaga tccggctcaa    300 
               
               
                   
               
               
                 atattttgat actgtacccg ttgctgctgc catgtgtgtg cttaaaacag ggttcctttt    360 
               
               
                   
               
               
                 tgtagcatca gaatttggaa accattactt atatcaaatt gcacatcttg gagatgatga    420 
               
               
                   
               
               
                 tgaagaacct gagttttcat cagccatgcc tctggaagaa ggagacacat tcttttttca    480 
               
               
                   
               
               
                 gccmagacca cttaaaaacc ttgtgctggt tgatgagttg gacagcctct ctcccattct    540 
               
               
                   
               
               
                 gttttgccag atagctgatc tggccaatga agatactcca cagttgtatg tggcctgtgg    600 
               
               
                   
               
               
                 taggggaccc cgatcatctc tgagagtcct aagacatgga cttgaggtgt cagaaatggc    660 
               
               
                   
               
               
                 tgtttctgag ctacctggta accccaacgc tgtctggaca gtgcgtcgac acattgaaga    720 
               
               
                   
               
               
                 tgagtttgat gcctacatca ttgtgtcttt cgtgaatgcc accctagtgt tgtccattgg    780 
               
               
                   
               
               
                 agaaactgta gaagaagtga ctgactctgg gttcctgggg accaccccga ccttgtcctg    840 
               
               
                   
               
               
                 ctccttatta ggagatgatg ccttggtgca ggtctatcca gatggcattc ggcacatacg    900 
               
               
                   
               
               
                 agcagacaag agagtcaatg agtggaagac ccctggaaag aaaacaattg tgaagtgtgc    960 
               
               
                   
               
               
                 agtgaaccag cgacaagtgg tgattgccct gacaggagga gagctggtct atttcgagat   1020 
               
               
                   
               
               
                 ggatccttca ggacagctga atgagtacac agaacggaag gagatgtcag cagatgtggt   1080 
               
               
                   
               
               
                 gtgcatgagt ctggccaatg taccccctgg agagcagcgg tctcgcttcc tggctgtggg   1140 
               
               
                   
               
               
                 gcttgtggac aacactgtca gaatcatctc cctggatccc tcagactgtt tgcaacctct   1200 
               
               
                   
               
               
                 aagcatgcag gctctcccag cccagcctga gtccttgtgt atcgtggaaa tgggtgggac   1260 
               
               
                   
               
               
                 tgagaagcag gatgagctgg gtgagagggg ctcgattggc ttcctatacc tgaatattgg   1320 
               
               
                   
               
               
                 gctacagaac ggtgtgctgc tgaggactgt cttggaccct gtcactgggg atttgtctga   1380 
               
               
                   
               
               
                 tactcgcact cggtacctgg ggtcccgtcc tgtgaagctc ttccgagtcc gaatgcaagg   1440 
               
               
                   
               
               
                 ccaggaggca gtattggcca tgtcaagccg ctcatggttg agctattctt accaatctcg   1500 
               
               
                   
               
               
                 cttccatctc accccactgt cttacgagac actggaattt gcatcgggtt ttgcctcgga   1560 
               
               
                   
               
               
                 acagtgtccc gagggcattg tggccatctc caccaacacc ctacggattt tggcattaga   1620 
               
               
                   
               
               
                 gaagctcggt gctgtcttca atcaagtagc cttcccactg cagtacacac ccaggaaatt   1680 
               
               
                   
               
               
                 tgtcatccac cctgagagta acaaccttat tatcattgaa acggaccaca atgcctacac   1740 
               
               
                   
               
               
                 tgaggccacg aaagctcaga gaaagcagca gatggcagag gaaatggtgg aagcagcagg   1800 
               
               
                   
               
               
                 ggaggatgag cgggagctgg ccgcagagat ggcagcagca ttcctcaatg aaaacctccc   1860 
               
               
                   
               
               
                 tgaatccatc tttggagctc ccaaggctgg caatgggcag tgggcctctg tgatccgagt   1920 
               
               
                   
               
               
                 gatgaatccc attcaaggga acacactgga ccttgtccag ctggaacaga atgaggcagc   1980 
               
               
                   
               
               
                 ttttagtgtg gctgtgtgca ggttttccaa cactggtgaa gactggtatg tgctggtggg   2040 
               
               
                   
               
               
                 tgtggccaag gacctgatac taaacccccg atctgtggca gggggcttcg tctatactta   2100 
               
               
                   
               
               
                 caagcttgtg aacaatgggg aaaaactgga gtttttgcac aagactcctg tggaagaggt   2160 
               
               
                   
               
               
                 ccctgctgct attgccccat tccaggggag ggtgttgatt ggtgtgggga agctgttgcg   2220 
               
               
                   
               
               
                 tgtctatgac ctgggaaaga agaagttact ccgaaaatgt gagaataagc atattgccaa   2280 
               
               
                   
               
               
                 ttatatctct gggatccaga ctattggaca tagggtaatt gtatctgatg tccaagaaag   2340 
               
               
                   
               
               
                 tttcatctgg gttcgctaca agcgtaatga aaaccagctt atcatctttg ctgatgatac   2400 
               
               
                   
               
               
                 ctacccccga tgggtcacta cagccagcct cttggactat gacactgtgg ctggggcaga   2460 
               
               
                   
               
               
                 caagtttggc aacatatgtg tggtgaggct cccacctaac accaatgatg aagtagatga   2520 
               
               
                   
               
               
                 ggatcctaca ggaaacaaag ccctgtggga ccgtggcttg ctcaatgggg cctcccagaa   2580 
               
               
                   
               
               
                 ggcagaggtg atcatgaatt accatgtcgg ggagacggtg ctgtccttgc agaagaccac   2640 
               
               
                   
               
               
                 gctgatccct ggaggctcag aatcacttgt ctataccacc ttgtctggag gaattggcat   2700 
               
               
                   
               
               
                 ccttgtgcca ttcacgtccc atgaggacca tgacttcttc cagcatgtgg aaatgcacct   2760 
               
               
                   
               
               
                 gcggtctgaa catccccctc tctgtgggcg ggaccacctc agctttcgct cctactactt   2820 
               
               
                   
               
               
                 ccctgtgaag aatgtgattg atggagacct ctgtgagcag ttcaattcca tggaacccaa   2880 
               
               
                   
               
               
                 caaacaaaag aacgtctctg aagaactgga ccgaacccca cccgaagtgt ccaagaaact   2940 
               
               
                   
               
               
                 cgaggatatc cggacccgct acgccttctg agccctcctt tcccggtggg gcttgccaga   3000 
               
               
                   
               
               
                 gactgtgtgt tttgtttccc ccaccaccat castgccacc tggcttctgc catgtggcag   3060 
               
               
                   
               
               
                 gagggtgact ggataattaa gastgcatta tgaaagtcaa cagctctttc ccctcagctc   3120 
               
               
                   
               
               
                 ttctcstgga atgactggct tcccctcaaa ttggcactga gatttgctac acttctcccc   3180 
               
               
                   
               
               
                 acctggtaca tgatacatga ccccaggttc cagtgtagaa cctgagtccc ccattcccca   3240 
               
               
                   
               
               
                 aagccatccc tgcattgata tgtcttgact ctcctgtcta cttttgcaca cacccttaat   3300 
               
               
                   
               
               
                 ttttaattgg ttttcttgta aatacaaaaa aaaaaaaaaa                         3340 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 22 
               
               
                 &lt;211&gt; LENGTH: 933 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 22 
               
               
                   
               
               
                 Met Ile Phe Val Cys Ser Ala Thr His Lys Thr Lys Ser Met Phe Phe 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Phe Leu Ala Gln Thr Glu Gln Gly Asp Ile Phe Lys Ile Thr Leu Glu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Thr Asp Glu Asp Met Val Thr Glu Ile Arg Leu Lys Tyr Phe Asp Thr 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Val Pro Val Ala Ala Ala Met Cys Val Leu Lys Thr Gly Phe Leu Phe 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Val Ala Ser Glu Phe Gly Asn His Tyr Leu Tyr Gln Ile Ala His Leu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly Asp Asp Asp Glu Glu Pro Glu Phe Ser Ser Ala Met Pro Leu Glu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Glu Gly Asp Thr Phe Phe Phe Gln Pro Arg Pro Leu Lys Asn Leu Val 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Leu Val Asp Glu Leu Asp Ser Leu Ser Pro Ile Leu Phe Cys Gln Ile 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Ala Asp Leu Ala Asn Glu Asp Thr Pro Gln Leu Tyr Val Ala Cys Gly 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Arg Gly Pro Arg Ser Ser Leu Arg Val Leu Arg His Gly Leu Glu Val 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Ser Glu Met Ala Val Ser Glu Leu Pro Gly Asn Pro Asn Ala Val Trp 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Thr Val Arg Arg His Ile Glu Asp Glu Phe Asp Ala Tyr Ile Ile Val 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Ser Phe Val Asn Ala Thr Leu Val Leu Ser Ile Gly Glu Thr Val Glu 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Glu Val Thr Asp Ser Gly Phe Leu Gly Thr Thr Pro Thr Leu Ser Cys 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Ser Leu Leu Gly Asp Asp Ala Leu Val Gln Val Tyr Pro Asp Gly Ile 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Arg His Ile Arg Ala Asp Lys Arg Val Asn Glu Trp Lys Thr Pro Gly 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Lys Lys Thr Ile Val Lys Cys Ala Val Asn Gln Arg Gln Val Val Ile 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Ala Leu Thr Gly Gly Glu Leu Val Tyr Phe Glu Met Asp Pro Ser Gly 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Gln Leu Asn Glu Tyr Thr Glu Arg Lys Glu Met Ser Ala Asp Val Val 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Cys Met Ser Leu Ala Asn Val Pro Pro Gly Glu Gln Arg Ser Arg Phe 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Leu Ala Val Gly Leu Val Asp Asn Thr Val Arg Ile Ile Ser Leu Asp 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Pro Ser Asp Cys Leu Gln Pro Leu Ser Met Gln Ala Leu Pro Ala Gln 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Pro Glu Ser Leu Cys Ile Val Glu Met Gly Gly Thr Glu Lys Gln Asp 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 Glu Leu Gly Glu Arg Gly Ser Ile Gly Phe Leu Tyr Leu Asn Ile Gly 
               
               
                     370                 375                 380 
               
               
                   
               
               
                 Leu Gln Asn Gly Val Leu Leu Arg Thr Val Leu Asp Pro Val Thr Gly 
               
               
                 385                 390                 395                 400 
               
               
                   
               
               
                 Asp Leu Ser Asp Thr Arg Thr Arg Tyr Leu Gly Ser Arg Pro Val Lys 
               
               
                                 405                 410                 415 
               
               
                   
               
               
                 Leu Phe Arg Val Arg Met Gln Gly Gln Glu Ala Val Leu Ala Met Ser 
               
               
                             420                 425                 430 
               
               
                   
               
               
                 Ser Arg Ser Trp Leu Ser Tyr Ser Tyr Gln Ser Arg Phe His Leu Thr 
               
               
                         435                 440                 445 
               
               
                   
               
               
                 Pro Leu Ser Tyr Glu Thr Leu Glu Phe Ala Ser Gly Phe Ala Ser Glu 
               
               
                     450                 455                 460 
               
               
                   
               
               
                 Gln Cys Pro Glu Gly Ile Val Ala Ile Ser Thr Asn Thr Leu Arg Ile 
               
               
                 465                 470                 475                 480 
               
               
                   
               
               
                 Leu Ala Leu Glu Lys Leu Gly Ala Val Phe Asn Gln Val Ala Phe Pro 
               
               
                                 485                 490                 495 
               
               
                   
               
               
                 Leu Gln Tyr Thr Pro Arg Lys Phe Val Ile His Pro Glu Ser Asn Asn 
               
               
                             500                 505                 510 
               
               
                   
               
               
                 Leu Ile Ile Ile Glu Thr Asp His Asn Ala Tyr Thr Glu Ala Thr Lys 
               
               
                         515                 520                 525 
               
               
                   
               
               
                 Ala Gln Arg Lys Gln Gln Met Ala Glu Glu Met Val Glu Ala Ala Gly 
               
               
                     530                 535                 540 
               
               
                   
               
               
                 Glu Asp Glu Arg Glu Leu Ala Ala Glu Met Ala Ala Ala Phe Leu Asn 
               
               
                 545                 550                 555                 560 
               
               
                   
               
               
                 Glu Asn Leu Pro Glu Ser Ile Phe Gly Ala Pro Lys Ala Gly Asn Gly 
               
               
                                 565                 570                 575 
               
               
                   
               
               
                 Gln Trp Ala Ser Val Ile Arg Val Met Asn Pro Ile Gln Gly Asn Thr 
               
               
                             580                 585                 590 
               
               
                   
               
               
                 Leu Asp Leu Val Gln Leu Glu Gln Asn Glu Ala Ala Phe Ser Val Ala 
               
               
                         595                 600                 605 
               
               
                   
               
               
                 Val Cys Arg Phe Ser Asn Thr Gly Glu Asp Trp Tyr Val Leu Val Gly 
               
               
                     610                 615                 620 
               
               
                   
               
               
                 Val Ala Lys Asp Leu Ile Leu Asn Pro Arg Ser Val Ala Gly Gly Phe 
               
               
                 625                 630                 635                 640 
               
               
                   
               
               
                 Val Tyr Thr Tyr Lys Leu Val Asn Asn Gly Glu Lys Leu Glu Phe Leu 
               
               
                                 645                 650                 655 
               
               
                   
               
               
                 His Lys Thr Pro Val Glu Glu Val Pro Ala Ala Ile Ala Pro Phe Gln 
               
               
                             660                 665                 670 
               
               
                   
               
               
                 Gly Arg Val Leu Ile Gly Val Gly Lys Leu Leu Arg Val Tyr Asp Leu 
               
               
                         675                 680                 685 
               
               
                   
               
               
                 Gly Lys Lys Lys Leu Leu Arg Lys Cys Glu Asn Lys His Ile Ala Asn 
               
               
                     690                 695                 700 
               
               
                   
               
               
                 Tyr Ile Ser Gly Ile Gln Thr Ile Gly His Arg Val Ile Val Ser Asp 
               
               
                 705                 710                 715                 720 
               
               
                   
               
               
                 Val Gln Glu Ser Phe Ile Trp Val Arg Tyr Lys Arg Asn Glu Asn Gln 
               
               
                                 725                 730                 735 
               
               
                   
               
               
                 Leu Ile Ile Phe Ala Asp Asp Thr Tyr Pro Arg Trp Val Thr Thr Ala 
               
               
                             740                 745                 750 
               
               
                   
               
               
                 Ser Leu Leu Asp Tyr Asp Thr Val Ala Gly Ala Asp Lys Phe Gly Asn 
               
               
                         755                 760                 765 
               
               
                   
               
               
                 Ile Cys Val Val Arg Leu Pro Pro Asn Thr Asn Asp Glu Val Asp Glu 
               
               
                     770                 775                 780 
               
               
                   
               
               
                 Asp Pro Thr Gly Asn Lys Ala Leu Trp Asp Arg Gly Leu Leu Asn Gly 
               
               
                 785                 790                 795                 800 
               
               
                   
               
               
                 Ala Ser Gln Lys Ala Glu Val Ile Met Asn Tyr His Val Gly Glu Thr 
               
               
                                 805                 810                 815 
               
               
                   
               
               
                 Val Leu Ser Leu Gln Lys Thr Thr Leu Ile Pro Gly Gly Ser Glu Ser 
               
               
                             820                 825                 830 
               
               
                   
               
               
                 Leu Val Tyr Thr Thr Leu Ser Gly Gly Ile Gly Ile Leu Val Pro Phe 
               
               
                         835                 840                 845 
               
               
                   
               
               
                 Thr Ser His Glu Asp His Asp Phe Phe Gln His Val Glu Met His Leu 
               
               
                     850                 855                 860 
               
               
                   
               
               
                 Arg Ser Glu His Pro Pro Leu Cys Gly Arg Asp His Leu Ser Phe Arg 
               
               
                 865                 870                 875                 880 
               
               
                   
               
               
                 Ser Tyr Tyr Phe Pro Val Lys Asn Val Ile Asp Gly Asp Leu Cys Glu 
               
               
                                 885                 890                 895 
               
               
                   
               
               
                 Gln Phe Asn Ser Met Glu Pro Asn Lys Gln Lys Asn Val Ser Glu Glu 
               
               
                             900                 905                 910 
               
               
                   
               
               
                 Leu Asp Arg Thr Pro Pro Glu Val Ser Lys Lys Leu Glu Asp Ile Arg 
               
               
                         915                 920                 925 
               
               
                   
               
               
                 Thr Arg Tyr Ala Phe 
               
               
                     930 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 23 
               
               
                 &lt;211&gt; LENGTH: 1496 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 23 
               
               
                   
               
               
                 gccagcccca ccgctgaccc agagcttgga actgaggagc cccaggcagg gagttgatgg     60 
               
               
                   
               
               
                 gaccccgaaa gaaagtgtgg gatggagggt ctagccccgg gcagctgcgg ctcartgggc    120 
               
               
                   
               
               
                 agcsggaccc cgggaggagg aggcggcacc tccgccccac agcctcaccc ggcccttccc    180 
               
               
                   
               
               
                 tcccgctcac ttggctgcaa gccagtgtcc tccgtggtga gccggccctt gctgctctgc    240 
               
               
                   
               
               
                 atgatcaggc tcgggaacct gaggtcagcc atgctgtgct ccggcagccc ctgcctgcct    300 
               
               
                   
               
               
                 cctcgcggag cccttctgcc ccttgggctg cstgtgccgg ggcgaggcct gtgtggggcc    360 
               
               
                   
               
               
                 tgtgatggca gctcctggaa aacgctgtgg ggcaggggtg aggcccacga ggccatgggg    420 
               
               
                   
               
               
                 acagctcacc atggggagca cacctgcagg tggggagggc tgcctttccc cacagcactc    480 
               
               
                   
               
               
                 agaagatgca cgtggccggg gctgatgagc tgccccgagc cacccctggg ggtcactgag    540 
               
               
                   
               
               
                 ggcagggctg gcagcacaga tgcccctgct cggggcctga gtggggccag cgctgacagg    600 
               
               
                   
               
               
                 ctgtcctctc gtcctctttt tcatggcggc ggtccttctt cagatgacga cgccggctct    660 
               
               
                   
               
               
                 gcacccctga agagcagcgg gcagcaccag aatgacaaag gcaagaacgt ccgccagagg    720 
               
               
                   
               
               
                 aactcttcct gaggcaggtg gcccgaggac gctccctgct ccgcgtctgc gccgccgccg    780 
               
               
                   
               
               
                 gagtccactc ccagtgcttg caagattcca agttctcacc tcttaaagaa aacccacccc    840 
               
               
                   
               
               
                 gtagattccc atcatacact tccttctttt ttaaaaaagt tgggttttct ccattcagga    900 
               
               
                   
               
               
                 ttctgttcct taggattttt tccttctgaa gtgtttcacg agagcccggg agctgctgcc    960 
               
               
                   
               
               
                 ctgcggcccc gtctgtggct ttcagcctct gggtctgagt catggccggg tgggcggcac   1020 
               
               
                   
               
               
                 agccttctcc actggccgga gtcagtgcca ggtccttgcc ctttgtggaa agtcacaggt   1080 
               
               
                   
               
               
                 cacacgaggg gccccgtgtc ctgcctgtct gaagccaatg ctgtctggtt gcgccatttt   1140 
               
               
                   
               
               
                 tgtgctttta tgtttaattt tatgagggcc acgggtctgt gttcgactca gcctcaggga   1200 
               
               
                   
               
               
                 cgactctgac ctcttggcca cagaggactc acttgcccac accgagggcg accccgtcac   1260 
               
               
                   
               
               
                 agcctcaagt cactcccaag ccccctcctt gtctgtgcat ccgggggcag ctctggaggg   1320 
               
               
                   
               
               
                 ggtttgctgg ggaactggcg ccatcgccgg gactccagaa ccgcagaagc ctccccagct   1380 
               
               
                   
               
               
                 cacccctgga ggacggccgg ctctctatag caccagggct cacgtgggaa cccccctccc   1440 
               
               
                   
               
               
                 acccaccgcc acaataaaga tcgcccccac ctccaccctc aaaaaaaaaa aaaaaa       1496 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 24 
               
               
                 &lt;211&gt; LENGTH: 216 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: UNSURE 
               
               
                 &lt;222&gt; LOCATION: (12) 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: UNSURE 
               
               
                 &lt;222&gt; LOCATION: (15) 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: UNSURE 
               
               
                 &lt;222&gt; LOCATION: (84) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 24 
               
               
                   
               
               
                 Met Glu Gly Leu Ala Pro Gly Ser Cys Gly Ser Xaa Gly Ser Xaa Thr 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Pro Gly Gly Gly Gly Gly Thr Ser Ala Pro Gln Pro His Pro Ala Leu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Pro Ser Arg Ser Leu Gly Cys Lys Pro Val Ser Ser Val Val Ser Arg 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Pro Leu Leu Leu Cys Met Ile Arg Leu Gly Asn Leu Arg Ser Ala Met 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Cys Ser Gly Ser Pro Cys Leu Pro Pro Arg Gly Ala Leu Leu Pro 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Gly Leu Xaa Val Pro Gly Arg Gly Leu Cys Gly Ala Cys Asp Gly 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ser Ser Trp Lys Thr Leu Trp Gly Arg Gly Glu Ala His Glu Ala Met 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Gly Thr Ala His His Gly Glu His Thr Cys Arg Trp Gly Gly Leu Pro 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Phe Pro Thr Ala Leu Arg Arg Cys Thr Trp Pro Gly Leu Met Ser Cys 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Pro Glu Pro Pro Leu Gly Val Thr Glu Gly Arg Ala Gly Ser Thr Asp 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Ala Pro Ala Arg Gly Leu Ser Gly Ala Ser Ala Asp Arg Leu Ser Ser 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Arg Pro Leu Phe His Gly Gly Gly Pro Ser Ser Asp Asp Asp Ala Gly 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln Asn Asp Lys Gly Lys 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Asn Val Arg Gln Arg Asn Ser Ser 
               
               
                     210                 215 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 25 
               
               
                 &lt;211&gt; LENGTH: 2113 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 25 
               
               
                   
               
               
                 gcagctatgg ctgctggcgt accctgtgcg ttagtcacca gctgctcctc cgtcttctca     60 
               
               
                   
               
               
                 ggagaccagc tggtccaaca tatccttgga acagaagatc ttattgtgga agtgacttcc    120 
               
               
                   
               
               
                 aatgatgctg tgagatttta tccctggacc attgataata aatactattc agcagacatc    180 
               
               
                   
               
               
                 aatctatgtg tggtgccaaa caaatttctt gttactgcag agattgcaga atctgtccaa    240 
               
               
                   
               
               
                 gcatttgtgg tttactttga cagcacacaa aaatcgggcc ttgatagtgt ctcctcrtgg    300 
               
               
                   
               
               
                 cttccactgg caaaagcatg gttacctgag gtgatgatct tggtctgcga tagagtgtct    360 
               
               
                   
               
               
                 gaagatggta taaaccgaca aaaagctcaa gaatggtgcc tcaaacatgg ctttgaattg    420 
               
               
                   
               
               
                 gtagaactta gtccagagga gttgcctgag gaggatgatg acttcccaga atctacagga    480 
               
               
                   
               
               
                 gtaaagcgaa ttgtccaagc cctgaatgcc aatgtgtggt ccaatgtagt gatgaagaat    540 
               
               
                   
               
               
                 gataggaacc aaggctttag ccttctcaac tcattgactg gaacaaacca tagcattggg    600 
               
               
                   
               
               
                 tcagcagatc cctgtcaccc agagcaaccc catttgccag cagcagatag tactgaatcc    660 
               
               
                   
               
               
                 ctctctgatc atcggggtgg tgcatctaac acaacagatg cccaggttga tagcattgtg    720 
               
               
                   
               
               
                 gatcccatgt tagatctgga tattcaagaa ttagccagtc ttaccactgg aggaggagat    780 
               
               
                   
               
               
                 gtggagaatt ttgaaagact cttttcaaag ttaaaggaaa tgaaagacaa ggctgcgacg    840 
               
               
                   
               
               
                 cttcctcatg agcaaagaaa agtgcatgca gaaaaggtgg ccaaagcatt ctggatggca    900 
               
               
                   
               
               
                 atcgggggag acagagatga aattgaaggc ctttcatctg atgaagagca ctgaattatt    960 
               
               
                   
               
               
                 catactaggg tttgaccaac aaagatgcta gctgtctctg agatacctct ctactcagcc   1020 
               
               
                   
               
               
                 cagtcatatt ttgccaaaat tgcccttatc atgttggctg cctgacttgt ttatagggtc   1080 
               
               
                   
               
               
                 cccttaattt tagtttttag taggaggtta aggagaaatc ttttttttcc tcagtatatt   1140 
               
               
                   
               
               
                 gtaagagagt gaggaataca gtgatagtaa tgagtgagga tttcttaaat gtactttttt   1200 
               
               
                   
               
               
                 tttgttctag gaatgagggt aggataaatc tcagaggtct gtgtgattta ctcaagttga   1260 
               
               
                   
               
               
                 agacaacctc caggccattc ctggtcaacg ttttaagtag catttccagc attcacactt   1320 
               
               
                   
               
               
                 gatactgcac atcaggagtt gtgtcacctt tcctgggtga tttgggtttt ctccattcaa   1380 
               
               
                   
               
               
                 ggagcttgta gctctgagct atgatgcttt tattgggagg aaaggaggca gctgcagaat   1440 
               
               
                   
               
               
                 tgatgtgagc tatgtggggc cgaagtctca gcccgcagct aagtctctac ctaagaaaat   1500 
               
               
                   
               
               
                 gcctctgggc attcttttga agtatagtgt ctgagctcat gctagaaaga atcaaaaagc   1560 
               
               
                   
               
               
                 cagtgtggat ttttagactg taataaatga ggcaaaggat ttctattcca gtgggaagaa   1620 
               
               
                   
               
               
                 aacctctcta ctgagttgtg ggggatatgt tgtatgttag agagaacctt aaggagtcct   1680 
               
               
                   
               
               
                 tgtatgggcc atggagacag tatgtgataa cataccgtga ttttcatgaa gaaattcttc   1740 
               
               
                   
               
               
                 tgtcttagag ttctcccctg ctgcttgaga tgccagagct gtgttgttgc acacctgcaa   1800 
               
               
                   
               
               
                 aacaaggcac atttccccct ttctctttaa agccaaagag agatcactgc caaagtggga   1860 
               
               
                   
               
               
                 gcactaaggg gtgggtgggg aagtgaaatg ttaggcgatg aattcctgag caccttgttt   1920 
               
               
                   
               
               
                 ttcttccaag gttcgtagct tctctctgcc cttccaagcc tgtaacctcg gaggactatc   1980 
               
               
                   
               
               
                 ttttgttctt tatcctttgt cttgttwgag tgggtcagcc ccagaggaac tgataagcaa   2040 
               
               
                   
               
               
                 atggcaagtt tttaaaggaa gagtggaaag tactgcaaat aaaaatcctt atttgttaaa   2100 
               
               
                   
               
               
                 aaaaaaaaaa aaa                                                      2113 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 26 
               
               
                 &lt;211&gt; LENGTH: 315 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 26 
               
               
                   
               
               
                 Met Ala Ala Gly Val Pro Cys Ala Leu Val Thr Ser Cys Ser Ser Val 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Phe Ser Gly Asp Gln Leu Val Gln His Ile Leu Gly Thr Glu Asp Leu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ile Val Glu Val Thr Ser Asn Asp Ala Val Arg Phe Tyr Pro Trp Thr 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ile Asp Asn Lys Tyr Tyr Ser Ala Asp Ile Asn Leu Cys Val Val Pro 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Asn Lys Phe Leu Val Thr Ala Glu Ile Ala Glu Ser Val Gln Ala Phe 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Val Val Tyr Phe Asp Ser Thr Gln Lys Ser Gly Leu Asp Ser Val Ser 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ser Trp Leu Pro Leu Ala Lys Ala Trp Leu Pro Glu Val Met Ile Leu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Val Cys Asp Arg Val Ser Glu Asp Gly Ile Asn Arg Gln Lys Ala Gln 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Glu Trp Cys Leu Lys His Gly Phe Glu Leu Val Glu Leu Ser Pro Glu 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Glu Leu Pro Glu Glu Asp Asp Asp Phe Pro Glu Ser Thr Gly Val Lys 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Arg Ile Val Gln Ala Leu Asn Ala Asn Val Trp Ser Asn Val Val Met 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Lys Asn Asp Arg Asn Gln Gly Phe Ser Leu Leu Asn Ser Leu Thr Gly 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Thr Asn His Ser Ile Gly Ser Ala Asp Pro Cys His Pro Glu Gln Pro 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 His Leu Pro Ala Ala Asp Ser Thr Glu Ser Leu Ser Asp His Arg Gly 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Gly Ala Ser Asn Thr Thr Asp Ala Gln Val Asp Ser Ile Val Asp Pro 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Met Leu Asp Leu Asp Ile Gln Glu Leu Ala Ser Leu Thr Thr Gly Gly 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Gly Asp Val Glu Asn Phe Glu Arg Leu Phe Ser Lys Leu Lys Glu Met 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Lys Asp Lys Ala Ala Thr Leu Pro His Glu Gln Arg Lys Val His Ala 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Glu Lys Val Ala Lys Ala Phe Trp Met Ala Ile Gly Gly Asp Arg Asp 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Glu Ile Glu Gly Leu Ser Ser Asp Glu Glu His 
               
               
                 305                 310                 315 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 27 
               
               
                 &lt;211&gt; LENGTH: 1541 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 27 
               
               
                   
               
               
                 ttaaaagaca aaattttaaa atctgacccc agcccttgtg attgttcagt atataatcaa     60 
               
               
                   
               
               
                 tggtatctta caaggactat tttatttgga atcaatcaaa tttgtttcct gccaacaata    120 
               
               
                   
               
               
                 agttaggttg ttttttgcag ttctcaagta acaaatatga ggaccgaact ctcattcaac    180 
               
               
                   
               
               
                 atccaagccc ttgcagtttg tgcaaatata tgtttagcaa caaaggacag acagaatcca    240 
               
               
                   
               
               
                 tcattagtat ggctttttac tggaatgttt tgcatttatt cattgttctt tgcttggaga    300 
               
               
                   
               
               
                 gcaaatttag atatttcaaa accacttttc atgggtgtgg tggaacgatt ctggatgcag    360 
               
               
                   
               
               
                 agcaatgcag tagtggccgt cctcgctggc attggtttgg ctgcagttgt gtctgagact    420 
               
               
                   
               
               
                 aaccgagtgc tgaatagcaa tgggcttcag tgtctggaat ggctttctgc mactcttttt    480 
               
               
                   
               
               
                 gtagtttacc aaatatattc taattacaga aaagaaacat ttgtttgcat aggaattcat    540 
               
               
                   
               
               
                 gaaggcgacc caacctggaa aaagaactat tcactttggc catgggggtc ttgtgacaaa    600 
               
               
                   
               
               
                 ttagttcctt tggagattgt attcaaccct gaggaatgga ttaaacttac aaaaaatatc    660 
               
               
                   
               
               
                 tataactgga ccgaagaata tggaaggttt gatccatctt cttgggaatc tgtggccaat    720 
               
               
                   
               
               
                 gaagaaatgt ggcaagcgag gatgaaaaca ccgttcttca tctttaacct ggcagaaact    780 
               
               
                   
               
               
                 gctcacatgc cttcaaaagt gaaagctcaa ctctacgctc aagcatatga cctttataag    840 
               
               
                   
               
               
                 gagattgtct atttacaaaa ggagcaccca gtgaattggc acaagaacta tgccatcgcc    900 
               
               
                   
               
               
                 tgtgagcgga tgctgcgtct tcaggcaaga gatgcagatc ctgaagtgct gttatcggaa    960 
               
               
                   
               
               
                 accatcagac atttccgtct gtactctcag aaagcaccga atgacccaca gcaagctgat   1020 
               
               
                   
               
               
                 attttaggtg ctctaaagca cctaagaaaa gaactgcaaa gtctgagaaa taggaaaaat   1080 
               
               
                   
               
               
                 gtctgagaca gcaaaatatg aaaaacctgc tcatcgttca gcttccaaaa ttctgaagtc   1140 
               
               
                   
               
               
                 tggaagtttt tccttcaaag aaaagaaact gcataaaaaa tttaaaacta agtcatctcc   1200 
               
               
                   
               
               
                 cagatataag tatcatggtc cagcagtact gtttaatggg gtattcagtg actaaggtct   1260 
               
               
                   
               
               
                 gctatttatg caaaattctg tttatcccgt gttaccaaat taccatttca gtgagaagct   1320 
               
               
                   
               
               
                 tttgaaaagt cttctgactt ccagtctttc accagatgac tgcactggat tagattctag   1380 
               
               
                   
               
               
                 aagagaatga accattttca tataactaaa tattggtcat gaactgtgta agggccatgc   1440 
               
               
                   
               
               
                 ttattgggat cagttttaaa gttaaattct tttgatatta ataccagacc aaagacattt   1500 
               
               
                   
               
               
                 tctgtttcct gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       1541 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 28 
               
               
                 &lt;211&gt; LENGTH: 309 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 28 
               
               
                   
               
               
                 Met Arg Thr Glu Leu Ser Phe Asn Ile Gln Ala Leu Ala Val Cys Ala 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Asn Ile Cys Leu Ala Thr Lys Asp Arg Gln Asn Pro Ser Leu Val Trp 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Phe Thr Gly Met Phe Cys Ile Tyr Ser Leu Phe Phe Ala Trp Arg 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ala Asn Leu Asp Ile Ser Lys Pro Leu Phe Met Gly Val Val Glu Arg 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Phe Trp Met Gln Ser Asn Ala Val Val Ala Val Leu Ala Gly Ile Gly 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Ala Ala Val Val Ser Glu Thr Asn Arg Val Leu Asn Ser Asn Gly 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Leu Gln Cys Leu Glu Trp Leu Ser Ala Thr Leu Phe Val Val Tyr Gln 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ile Tyr Ser Asn Tyr Arg Lys Glu Thr Phe Val Cys Ile Gly Ile His 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Glu Gly Asp Pro Thr Trp Lys Lys Asn Tyr Ser Leu Trp Pro Trp Gly 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Ser Cys Asp Lys Leu Val Pro Leu Glu Ile Val Phe Asn Pro Glu Glu 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Trp Ile Lys Leu Thr Lys Asn Ile Tyr Asn Trp Thr Glu Glu Tyr Gly 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Arg Phe Asp Pro Ser Ser Trp Glu Ser Val Ala Asn Glu Glu Met Trp 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Gln Ala Arg Met Lys Thr Pro Phe Phe Ile Phe Asn Leu Ala Glu Thr 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Ala His Met Pro Ser Lys Val Lys Ala Gln Leu Tyr Ala Gln Ala Tyr 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Asp Leu Tyr Lys Glu Ile Val Tyr Leu Gln Lys Glu His Pro Val Asn 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Trp His Lys Asn Tyr Ala Ile Ala Cys Glu Arg Met Leu Arg Leu Gln 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Ala Arg Asp Ala Asp Pro Glu Val Leu Leu Ser Glu Thr Ile Arg His 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Phe Arg Leu Tyr Ser Gln Lys Ala Pro Asn Asp Pro Gln Gln Ala Asp 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Ile Leu Gly Ala Leu Lys His Leu Arg Lys Glu Leu Gln Ser Leu Arg 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Asn Arg Lys Asn Val 
               
               
                 305 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 29 
               
               
                 &lt;211&gt; LENGTH: 539 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (495) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 29 
               
               
                   
               
               
                 gcgggccgga gggtgatggg accatctagc ccctaaccat gggcccagaa gagaagacca     60 
               
               
                   
               
               
                 tcatgacaga taggtctgca gctgttttca tccaggcctg gtggcggggc atgctggtgc    120 
               
               
                   
               
               
                 gacgacactg ctgcatgcag ccctcagggc ttggttcatt cagtgctggt ggaggcaggt    180 
               
               
                   
               
               
                 gctggagaag ctgctggcaa agaggcggag gatggtgttg gagttctatg tgcagcagga    240 
               
               
                   
               
               
                 atgggcagca gtcaggctgc agtcctgggt ccgcatgtgg tgtgtccgcc agcgtaactg    300 
               
               
                   
               
               
                 ttgtttgctc aacgctgtcc gcatcatcca ggtctattgg cgctggcaca gctgccattc    360 
               
               
                   
               
               
                 ccgtggcaaa attgagggcc actatgaact caaaaaaaac caacaaaaaa aacaacatga    420 
               
               
                   
               
               
                 aaacaccttg ggctaacagg cttgtaaggt gcaacaatgc ataccccttc cattaaaaaa    480 
               
               
                   
               
               
                 atgaccaggt ctgcnaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa     539 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 30 
               
               
                 &lt;211&gt; LENGTH: 145 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 30 
               
               
                   
               
               
                 Met Gly Pro Glu Glu Lys Thr Ile Met Thr Asp Arg Ser Ala Ala Val 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Phe Ile Gln Ala Trp Trp Arg Gly Met Leu Val Arg Arg His Cys Cys 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Met Gln Pro Ser Gly Leu Gly Ser Phe Ser Ala Gly Gly Gly Arg Cys 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Trp Arg Ser Cys Trp Gln Arg Gly Gly Gly Trp Cys Trp Ser Ser Met 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Cys Ser Arg Asn Gly Gln Gln Ser Gly Cys Ser Pro Gly Ser Ala Cys 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly Val Ser Ala Ser Val Thr Val Val Cys Ser Thr Leu Ser Ala Ser 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ser Arg Ser Ile Gly Ala Gly Thr Ala Ala Ile Pro Val Ala Lys Leu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Arg Ala Thr Met Asn Ser Lys Lys Thr Asn Lys Lys Asn Asn Met Lys 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Thr Pro Trp Ala Asn Arg Leu Val Arg Cys Asn Asn Ala Tyr Pro Phe 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 His 
               
               
                 145 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 31 
               
               
                 &lt;211&gt; LENGTH: 2408 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 31 
               
               
                   
               
               
                 cacatctcag agcctaagaa ataggactaa gcccagaact cctagaatca cctataaatg     60 
               
               
                   
               
               
                 ctaggcatag atggaaatta ttgtgttcca ccagaagcac agctccaaac tatacctaaa    120 
               
               
                   
               
               
                 aaatatttct gcacttccca gagacctgga cttcaaactt tcccagtgga gcctgattat    180 
               
               
                   
               
               
                 agaacttgag ggtcctatct caggatgaag gggagaggcc ctggcttcac gggaaggtat    240 
               
               
                   
               
               
                 tccagcattg ttctgcttca cccttgactg cgttgtctgg cagtttctgt gtgctgccag    300 
               
               
                   
               
               
                 gatattatat ggaactggag aagttggagt caggtctctg aagctagagt ttcactaatt    360 
               
               
                   
               
               
                 agatgcctct gtacatgaga actattactg tctgcaggtc catatagcta agctgccagg    420 
               
               
                   
               
               
                 aaaaacacat tatcttccaa aactttcaga gcatgtgcag aaccctttct tagcgttttc    480 
               
               
                   
               
               
                 ttctcagcat tttctctgcc tcccagaggc tggcagccag tgacactgca gagttcagca    540 
               
               
                   
               
               
                 tgttctaacc atgcacgcag ggcaggggct gccttggccc tcctcaggct ttcgttggga    600 
               
               
                   
               
               
                 gagcaggcag tggtggagcc cttctgggtg cagtcctctg gggttgctct ttggaactca    660 
               
               
                   
               
               
                 tgtatgagtt tgactccaca aggcttggca tggataccaa aacagttgca acaaattagt    720 
               
               
                   
               
               
                 tctgaacctg gaacagagaa ttcagtgctt ctgttactca ggaaggaggt gttcagaatg    780 
               
               
                   
               
               
                 ccccgtgcag agcagccagt cattactctt gtttgttctc acctgggtgc gcaccctcat    840 
               
               
                   
               
               
                 gatgcagtgg ctgtagcacc ttcatgccag gtgctgagag aatgggaaat tcttcctccc    900 
               
               
                   
               
               
                 cattgacctg agtcccagag acttagggac acagacttca ggtgaggctg cggacctcag    960 
               
               
                   
               
               
                 aagcagtgga taatagattg gggcattaaa agcttttgag gcagggggct catgttttga   1020 
               
               
                   
               
               
                 ctgcagggag ttatgctgag caaagagatg tgtttttcaa aaccagggtt caaaaccagt   1080 
               
               
                   
               
               
                 gtccacgctg gagtaagtgg agcatgcttc tctgtgttct ctgaatgatc ttgcactcct   1140 
               
               
                   
               
               
                 cttaagcaaa ggagtaccat gaccatagtc agtgggatcc cacaaatgtt cttaaatggg   1200 
               
               
                   
               
               
                 taaggcttta agtagccaga gagtatccag cctaccattg gcttctccac atcctaaaac   1260 
               
               
                   
               
               
                 ctgagacagc cttggtatat gctttataaa tgtttctttt cttgttgttt aagtaattaa   1320 
               
               
                   
               
               
                 agtgtttaaa atgtcttcat tagatgtgac gattgtttaa tgagtttgcc tctgacgtgt   1380 
               
               
                   
               
               
                 ggctccatgg gagataggca aagtaattaa gaagttacca gaaattggtc ggctggggaa   1440 
               
               
                   
               
               
                 atgcaaaagt tagcatttca gtagtgaatt tctcctggaa caaatgagca atttttcctc   1500 
               
               
                   
               
               
                 tttctcttaa gtagtatacc cttttctcac ttagtaattt aatggtatat aaagacatgt   1560 
               
               
                   
               
               
                 gtataagtga gtgcatacat atgaggtatg actatagggt tgtttgtggg aatttctttt   1620 
               
               
                   
               
               
                 cctaacatac agaagatcaa agtgttcatc tcaccccgcc ctccttaaaa ggtgtctttt   1680 
               
               
                   
               
               
                 gggagactat gtgctcattg actatagtgc tgccaagtaa aatatcttgg gaactcttct   1740 
               
               
                   
               
               
                 actagaatgg ccttcagggc ttggcatgtt cctttggttt acccttagag atgagaaatc   1800 
               
               
                   
               
               
                 ctcctccttt gaggatggat ttaagttctg gaaataatct caagtgcttg atagcacagt   1860 
               
               
                   
               
               
                 tggatgaaaa aagatggcaa ttaaggtaag ttacaccatt tttgtttcta aaaaaatccc   1920 
               
               
                   
               
               
                 taagaaattt cttggaatga gtctttggcc tcagagcctc tcaaagtgtc cacttcaagg   1980 
               
               
                   
               
               
                 ggggatcatc ctcattagca cacagatttt taaaaatcaa ttctcttgcc atgcctccta   2040 
               
               
                   
               
               
                 tgtgttcaca tctctgcata cactacagat ataagtgcat aatcattcat ataaacatct   2100 
               
               
                   
               
               
                 ggtaggtatt ctgtaaaact gtgtttactt tagtgcatgt tattgtcatg ttatgatgtg   2160 
               
               
                   
               
               
                 actggggtgt ttctttgtca tgaaactttg cttcttcaca gaattagaat actgctctct   2220 
               
               
                   
               
               
                 ctatattgaa ctacatatac agcgttttct tgtatcagcc cccaaagtct ggatgcccgg   2280 
               
               
                   
               
               
                 tgttgtgttt acatgtgatt gtgcctagga gtctgttcac atagagacac ctgtaagtat   2340 
               
               
                   
               
               
                 ttattacaaa acggaatgta agcaaatata tccacattgg ttttatttga aaaaaaaaaa   2400 
               
               
                   
               
               
                 aaaaaaaa                                                            2408 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 32 
               
               
                 &lt;211&gt; LENGTH: 80 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 32 
               
               
                   
               
               
                 Met Ser Leu Thr Pro Gln Gly Leu Ala Trp Ile Pro Lys Gln Leu Gln 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Gln Ile Ser Ser Glu Pro Gly Thr Glu Asn Ser Val Leu Leu Leu Leu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Arg Lys Glu Val Phe Arg Met Pro Arg Ala Glu Gln Pro Val Ile Thr 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Val Cys Ser His Leu Gly Ala His Pro His Asp Ala Val Ala Val 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ala Pro Ser Cys Gln Val Leu Arg Glu Trp Glu Ile Leu Pro Pro His 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 33 
               
               
                 &lt;211&gt; LENGTH: 970 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 33 
               
               
                   
               
               
                 gtgcgagatt gaggaagggt cggggcttaa cgggggaggt gggggtggcg gggggggaac     60 
               
               
                   
               
               
                 agcacggcgc ggcgcctagc ctgcgagatg gagtcggagt gggggtgcga gcggtcctcc    120 
               
               
                   
               
               
                 accgcctctg cccgatccgt acctcacaat ggactgctcg agtttgtatc taggcctgtc    180 
               
               
                   
               
               
                 caggattgtt tactccttca attaatcagc tttatctctt ttccccctcc ccccacctcc    240 
               
               
                   
               
               
                 accaaatctg gagaggagtg ggaaagaact ggaaaactca cagggcaaag agagaaagcc    300 
               
               
                   
               
               
                 aacagtcata gtgcgggagg aggcacgcct gggatgcaat acccaacagt ctcctccctg    360 
               
               
                   
               
               
                 ctttcctgca atttgcaggt cattgtcttt cttatttgta gctttttttt tttttcttca    420 
               
               
                   
               
               
                 gtagccggta aacaatcgaa cgacgggtag ggaggtcaga ggggatgggg ctgtgggaga    480 
               
               
                   
               
               
                 gattctactc aggctaggtg ctttagattt ggacctggct gtgtccctac tttattaaaa    540 
               
               
                   
               
               
                 ttctcatgtg gcgcgcgctg tcttctctct tctctctctc tctctctcac acacacacgc    600 
               
               
                   
               
               
                 acatacacac acagcccgag agaaatttcc aatcctttga gcaaatctct tccatctagt    660 
               
               
                   
               
               
                 ccttgaaaca gaggaaagga catgggacct gaaggagagt tatgattgaa ttttctaaaa    720 
               
               
                   
               
               
                 tttagttttg acattgcaaa gtaaaagtga ggaccgtatt cccaatacag acccagaggg    780 
               
               
                   
               
               
                 tggttatttc aggtgagggg acctcagcct gtgacgtcta tgatcaacca gacaaagacc    840 
               
               
                   
               
               
                 ccttcctaaa tctgaagtcc cacccccacc cgtggcaaac atggaataca agggagggga    900 
               
               
                   
               
               
                 aggatggcac aatagtgggt tctgttttcc aagaactgcc ccccacctcc attgcaaaaa    960 
               
               
                   
               
               
                 aaaaaaaaaa                                                           970 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 34 
               
               
                 &lt;211&gt; LENGTH: 120 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 34 
               
               
                   
               
               
                 Met Glu Ser Glu Trp Gly Cys Glu Arg Ser Ser Thr Ala Ser Ala Arg 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ser Val Pro His Asn Gly Leu Leu Glu Phe Val Ser Arg Pro Val Gln 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Asp Cys Leu Leu Leu Gln Leu Ile Ser Phe Ile Ser Phe Pro Pro Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Pro Thr Ser Thr Lys Ser Gly Glu Glu Trp Glu Arg Thr Gly Lys Leu 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Thr Gly Gln Arg Glu Lys Ala Asn Ser His Ser Ala Gly Gly Gly Thr 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Pro Gly Met Gln Tyr Pro Thr Val Ser Ser Leu Leu Ser Cys Asn Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Gln Val Ile Val Phe Leu Ile Cys Ser Phe Phe Phe Phe Ser Ser Val 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ala Gly Lys Gln Ser Asn Asp Gly 
               
               
                         115                 120 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 35 
               
               
                 &lt;211&gt; LENGTH: 2084 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 35 
               
               
                   
               
               
                 ggtagccgtt gggttgggaa agtgagggat ttttggcctc gtttctcctg cttcttttct     60 
               
               
                   
               
               
                 cctccctttt actttgccgg tagaacacag ttatgggtcg caagaagaag aagcagctga    120 
               
               
                   
               
               
                 agccgtggtg ctggtattgt catagagatt ttgatgatga gaagatcctt attcagcacc    180 
               
               
                   
               
               
                 aaaaagcaaa gcattttaaa tgccatatat gtcacaagaa attgtataca ggacctggct    240 
               
               
                   
               
               
                 tagctattca ttgcatgcag gtacataaag aaacaataga tgccgtacca aatgcaatac    300 
               
               
                   
               
               
                 ctggaagaac agacatagag ttggaaatat atggtatgga aggtattcca gaaaaagaca    360 
               
               
                   
               
               
                 tggatgaaag acgacgactt cttgaacaga aaacacaaga aagtctaaaa aagaagcaac    420 
               
               
                   
               
               
                 aagatgattc tgatgaatat gatgatgacg actctgcagc ctcaacttca tttcagccac    480 
               
               
                   
               
               
                 agcctgttca acctcagcaa ggttatattc ctccaatggc acagccagga ctgccaccag    540 
               
               
                   
               
               
                 taccaggagc accaggaatg cctccaggca tacctccatt aatgccacgt gttcctcctc    600 
               
               
                   
               
               
                 tgatgccagg aatgccacca gttatgccag gcatgccacc tggattgcat catcagagaa    660 
               
               
                   
               
               
                 aatacaccca gtcattttgc ggtgaaaaca taatgatgcc aatgggtgga atgatgccac    720 
               
               
                   
               
               
                 ctggaccagg aataccacct ctgatgcctg gaatgccacc aggtatgccc ccacctgttc    780 
               
               
                   
               
               
                 cacgtcctgg aattcctcca atgactcaag cacaggctgt ttcagcgcca ggtattctta    840 
               
               
                   
               
               
                 atagaccacc tgcaccaaca gcaactgtac ctgccccaca gcctccagtt actaagcctc    900 
               
               
                   
               
               
                 ttttccctag tgctggacag gctcaggcag ctgtccaagg acctgttggt acagatttca    960 
               
               
                   
               
               
                 aacccttaaa tagtacccct gcaacaacta cagaaccccc aaagcctaca ttccctgctt   1020 
               
               
                   
               
               
                 atacacagtc tacagcttca acaactagta caacaaatag tactgcagct aaaccagcgg   1080 
               
               
                   
               
               
                 cttcaataac aagtaagcct gctacactta caacaactag tgcaaccagt aagttgatcc   1140 
               
               
                   
               
               
                 atccagatga ggatatatcc ctggaagaga gaagggcaca gttacctaag tatcaacgta   1200 
               
               
                   
               
               
                 atcttcctcg gccaggacag gcccccatcg gtaatccacc agttggacca attggaggta   1260 
               
               
                   
               
               
                 tgatgccacc acagccaggc atcccacagc aacaaggaat gagaccccca atgccacctc   1320 
               
               
                   
               
               
                 atggtcagta tggtggtcat catcaaggca tgccaggata ccttcctggt gctatgcccc   1380 
               
               
                   
               
               
                 cgtatgggca gggaccgcca atggtgcccc cttaccaggg tgggcctcct cgacctccga   1440 
               
               
                   
               
               
                 tgggaatgag acctcctgta atgtcgcaag gtggccgtta ctgatcttac ttcatccagt   1500 
               
               
                   
               
               
                 ctaataggtt tggagattaa accttttctc aacttgtgct gtttatatag ccaagcttcc   1560 
               
               
                   
               
               
                 gtcaataagg cttcattgtg actttaacaa acattctctt cccacatacc aggaactatt   1620 
               
               
                   
               
               
                 ggacatttat tttacatggg aaaaattatt tggaataata aagcaggaac ttttcctgaa   1680 
               
               
                   
               
               
                 gttgcaattt atactgtatg gcttcttttt catgtttcat ctaggttttt agaagtgaag   1740 
               
               
                   
               
               
                 tatagtaaat ttggttcgtt aaattgtgaa ggcgctggaa ttacatgaac ataccaccct   1800 
               
               
                   
               
               
                 agtaaaggca agttctgtaa gcttacattg ctatttgtaa agtttgcctt cacagcattt   1860 
               
               
                   
               
               
                 cagatgctgt tggacttcat gtccccaacc tagcttggtg agggctgtaa ctgtttccaa   1920 
               
               
                   
               
               
                 gtacttgtac attggaagtc tgaatgtgta acaatattta atgtatttag agttcctcat   1980 
               
               
                   
               
               
                 gttgcagggt ttaagaaatc tgacccacca aggtcatgtg acttttctgt actgttaaac   2040 
               
               
                   
               
               
                 ttcattgtaa taaaatgaga gaaaaaaaaa aaaaaaaaaa aaaa                    2084 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 36 
               
               
                 &lt;211&gt; LENGTH: 463 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 36 
               
               
                   
               
               
                 Met Gly Arg Lys Lys Lys Lys Gln Leu Lys Pro Trp Cys Trp Tyr Cys 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 His Arg Asp Phe Asp Asp Glu Lys Ile Leu Ile Gln His Gln Lys Ala 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Lys His Phe Lys Cys His Ile Cys His Lys Lys Leu Tyr Thr Gly Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gly Leu Ala Ile His Cys Met Gln Val His Lys Glu Thr Ile Asp Ala 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Val Pro Asn Ala Ile Pro Gly Arg Thr Asp Ile Glu Leu Glu Ile Tyr 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly Met Glu Gly Ile Pro Glu Lys Asp Met Asp Glu Arg Arg Arg Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Leu Glu Gln Lys Thr Gln Glu Ser Leu Lys Lys Lys Gln Gln Asp Asp 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ser Asp Glu Tyr Asp Asp Asp Asp Ser Ala Ala Ser Thr Ser Phe Gln 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Pro Gln Pro Val Gln Pro Gln Gln Gly Tyr Ile Pro Pro Met Ala Gln 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Pro Gly Leu Pro Pro Val Pro Gly Ala Pro Gly Met Pro Pro Gly Ile 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Pro Pro Leu Met Pro Arg Val Pro Pro Leu Met Pro Gly Met Pro Pro 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Val Met Pro Gly Met Pro Pro Gly Leu His His Gln Arg Lys Tyr Thr 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Gln Ser Phe Cys Gly Glu Asn Ile Met Met Pro Met Gly Gly Met Met 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Pro Pro Gly Pro Gly Ile Pro Pro Leu Met Pro Gly Met Pro Pro Gly 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Met Pro Pro Pro Val Pro Arg Pro Gly Ile Pro Pro Met Thr Gln Ala 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Gln Ala Val Ser Ala Pro Gly Ile Leu Asn Arg Pro Pro Ala Pro Thr 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Ala Thr Val Pro Ala Pro Gln Pro Pro Val Thr Lys Pro Leu Phe Pro 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Ser Ala Gly Gln Ala Gln Ala Ala Val Gln Gly Pro Val Gly Thr Asp 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Phe Lys Pro Leu Asn Ser Thr Pro Ala Thr Thr Thr Glu Pro Pro Lys 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Pro Thr Phe Pro Ala Tyr Thr Gln Ser Thr Ala Ser Thr Thr Ser Thr 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Thr Asn Ser Thr Ala Ala Lys Pro Ala Ala Ser Ile Thr Ser Lys Pro 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Ala Thr Leu Thr Thr Thr Ser Ala Thr Ser Lys Leu Ile His Pro Asp 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Glu Asp Ile Ser Leu Glu Glu Arg Arg Ala Gln Leu Pro Lys Tyr Gln 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 Arg Asn Leu Pro Arg Pro Gly Gln Ala Pro Ile Gly Asn Pro Pro Val 
               
               
                     370                 375                 380 
               
               
                   
               
               
                 Gly Pro Ile Gly Gly Met Met Pro Pro Gln Pro Gly Ile Pro Gln Gln 
               
               
                 385                 390                 395                 400 
               
               
                   
               
               
                 Gln Gly Met Arg Pro Pro Met Pro Pro His Gly Gln Tyr Gly Gly His 
               
               
                                 405                 410                 415 
               
               
                   
               
               
                 His Gln Gly Met Pro Gly Tyr Leu Pro Gly Ala Met Pro Pro Tyr Gly 
               
               
                             420                 425                 430 
               
               
                   
               
               
                 Gln Gly Pro Pro Met Val Pro Pro Tyr Gln Gly Gly Pro Pro Arg Pro 
               
               
                         435                 440                 445 
               
               
                   
               
               
                 Pro Met Gly Met Arg Pro Pro Val Met Ser Gln Gly Gly Arg Tyr 
               
               
                     450                 455                 460 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 37 
               
               
                 &lt;211&gt; LENGTH: 1250 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 37 
               
               
                   
               
               
                 gtatgttgtc agaccagggt tttcagagtt gatggaaaag agtcttgtga gaaaacttat     60 
               
               
                   
               
               
                 tttgataaat tattacacac gcagaaaaac tgatcacact gactggatct gtccacgaca    120 
               
               
                   
               
               
                 tggaaaataa actggatttt cagaatattg ttgttttctg tagtgttcaa ggtattgttt    180 
               
               
                   
               
               
                 ctaaacataa acatactcta aacatgcttt attcacttgt taaagtcata cttttaaaag    240 
               
               
                   
               
               
                 taatacctta ctaaagatgg tgattacttt tccgaggtca gaaaaggaaa gctaagcgtt    300 
               
               
                   
               
               
                 ttcattatca aatacacaag cttattaaat gaatgactgt taactacttt attttcattt    360 
               
               
                   
               
               
                 gcacattaat tttggaattg tttctgtttt gctgctgacg gaaatactat tttggctctg    420 
               
               
                   
               
               
                 tgtatatttg tattttgatt tttctggttt gtttaccccc atttgctttt agctccgcct    480 
               
               
                   
               
               
                 tatgtttaaa tatattctaa cttatgtaaa gagcataatc ttagagcaaa aatacttgag    540 
               
               
                   
               
               
                 gttttatgtc agatctaatc ttaagtgttt gttgtttttt aaaaggtgtt ttctcagatg    600 
               
               
                   
               
               
                 gctgcagtgt ttttgctatt tctgcataaa taccctacct ggactcccca gttttcacca    660 
               
               
                   
               
               
                 gaaactgtta tttttttttg ttgttgttcc cactgagact gatggtgatg gggaaattaa    720 
               
               
                   
               
               
                 aaacaacaca ctagcacact cccacaaaac ttgaggaaga gttagaatgg caataaaata    780 
               
               
                   
               
               
                 ttaaatagac cttatactta aaataaggtt tcactatata atttgtcaca attcaatcta    840 
               
               
                   
               
               
                 atcagctaaa gttaaatgta gttagaatta gccacaggag aatgtaaagc atgctttgac    900 
               
               
                   
               
               
                 gaagctatcg gtaacacata ttgaatgtct ttgagactct tagattgtac tatttgctta    960 
               
               
                   
               
               
                 atagattaat gaaatttatc agatacaacc tgtatttcca aaaacaagct agaaggaacc   1020 
               
               
                   
               
               
                 tgaggaatgt ggtttacatt tgagatccac cttactgtgt tttctacttt cagaaaagat   1080 
               
               
                   
               
               
                 tctgtagttt tggtttttgg catctttctt atactcagtt ttttctgcct taattcccat   1140 
               
               
                   
               
               
                 ttaccagcag ttaactcatg tttattgtgc tttcatgcat tgtgatatgg aatgtgttta   1200 
               
               
                   
               
               
                 gtaatttact ccttataaat atggtaaagt acaaaaaaaa aaaaaaaaaa              1250 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 38 
               
               
                 &lt;211&gt; LENGTH: 90 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 38 
               
               
                   
               
               
                 Met Phe Lys Tyr Ile Leu Thr Tyr Val Lys Ser Ile Ile Leu Glu Gln 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Lys Tyr Leu Arg Phe Tyr Val Arg Ser Asn Leu Lys Cys Leu Leu Phe 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Phe Lys Arg Cys Phe Leu Arg Trp Leu Gln Cys Phe Cys Tyr Phe Cys 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ile Asn Thr Leu Pro Gly Leu Pro Ser Phe His Gln Lys Leu Leu Phe 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Phe Phe Val Val Val Pro Thr Glu Thr Asp Gly Asp Gly Glu Ile Lys 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Asn Asn Thr Leu Ala His Ser His Lys Thr 
               
               
                                  85                  90 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 39 
               
               
                 &lt;211&gt; LENGTH: 793 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 39 
               
               
                   
               
               
                 ggcgccttgg aggcgatggc ccacggggct gctagccgtg ctgcggcccc tgctcacctg     60 
               
               
                   
               
               
                 ccggcccctg caaggcacga cgctgcaacg ggatgtgctg ctctttgagc atgatcgggg    120 
               
               
                   
               
               
                 ccgcttcttc accatcctcg ggctgttctg cgcgggccag ggcgtcttct gggcttccat    180 
               
               
                   
               
               
                 ggctgtggca gccgtgtccc ggcccccggt tccggtgcag cctctggatg cggaggtccc    240 
               
               
                   
               
               
                 aaatcgtggc cccttcgacc tgcgctccgc gctctggcgc tacggtctgg ccgtcggctg    300 
               
               
                   
               
               
                 cggcgccatc ggagccctcg tactcggtgc tggtcttctc ttctctctcc ggtctgtgcg    360 
               
               
                   
               
               
                 ctcagtggtg cttcgagctg gagggcagca ggtgaccctc accactcatg ccccctttgg    420 
               
               
                   
               
               
                 cttgggggcc catttcacag ttcctttgaa gcaggtatct tgcatggccc accggggtga    480 
               
               
                   
               
               
                 agtccctgcc atgctacctc tgaaagtcaa aggccgacgc ttctatttcc tcttggacaa    540 
               
               
                   
               
               
                 aactggacac ttccctaaca caaaactctt tgacaatact gtgggtgcct accggagctt    600 
               
               
                   
               
               
                 gtgaagaaat gacctcaagt cactcacctc tccaagagga ggataaaaac tgaaccttgg    660 
               
               
                   
               
               
                 ggagccaggt gtgttggttc acgcctgttg taatcccagc actttgggag ggtgaggcag    720 
               
               
                   
               
               
                 gagcactgct cgagcccagg ctgggcaaca tagcgagacc ttgtctctat ttacaaaaaa    780 
               
               
                   
               
               
                 aaaaaaaaaa aaa                                                       793 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 40 
               
               
                 &lt;211&gt; LENGTH: 141 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 40 
               
               
                   
               
               
                 Met Ala Val Ala Ala Val Ser Arg Pro Pro Val Pro Val Gln Pro Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Asp Ala Glu Val Pro Asn Arg Gly Pro Phe Asp Leu Arg Ser Ala Leu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Trp Arg Tyr Gly Leu Ala Val Gly Cys Gly Ala Ile Gly Ala Leu Val 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Gly Ala Gly Leu Leu Phe Ser Leu Arg Ser Val Arg Ser Val Val 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Arg Ala Gly Gly Gln Gln Val Thr Leu Thr Thr His Ala Pro Phe 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly Leu Gly Ala His Phe Thr Val Pro Leu Lys Gln Val Ser Cys Met 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ala His Arg Gly Glu Val Pro Ala Met Leu Pro Leu Lys Val Lys Gly 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Arg Arg Phe Tyr Phe Leu Leu Asp Lys Thr Gly His Phe Pro Asn Thr 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Lys Leu Phe Asp Asn Thr Val Gly Ala Tyr Arg Ser Leu 
               
               
                     130                 135                 140 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 41 
               
               
                 &lt;211&gt; LENGTH: 1970 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 41 
               
               
                   
               
               
                 atggcctgtc cgcgttaaac catcacaagc catggttgcg gaagggccac gcgtccccag     60 
               
               
                   
               
               
                 taggagaatg actccgattc gtgaccctca gcgccggtgc atgtcgatat atttattgag    120 
               
               
                   
               
               
                 tgtctactgt gtgccaggca ctatatctat gtgcatagaa aaaccctgga aggccgtaca    180 
               
               
                   
               
               
                 acaatatata tagagtgatc gtctctgctt gctgagctaa cagcaagttt atttctgatc    240 
               
               
                   
               
               
                 gtgaaagtag aagaagtctc acaaacagcc atttggaaaa aaagaagtgt gatgagtata    300 
               
               
                   
               
               
                 ttccaggtac aacctcctta ggcatgtctg tttttaacct aagcaacgcc attatgggca    360 
               
               
                   
               
               
                 gtgggatttt gggactcgcc tttgccctgg caaacactgg aatcctactt tttctggtac    420 
               
               
                   
               
               
                 ttttgacttc agtgacattg ctgtctatat attcaataaa cctcctattg atctgttcaa    480 
               
               
                   
               
               
                 aagaaacagg ctgcatggtg tatgaaaagc tgggggaaca agtctttggc accacaggga    540 
               
               
                   
               
               
                 agttcgtaat ctttggagcc acctctctac agaacactgg agcaatgctg agctacctct    600 
               
               
                   
               
               
                 tcatcgtaaa aaatgaacta ccctctgcca taaagtttct aatgggaaag gaagagacat    660 
               
               
                   
               
               
                 tttcagcctg gtacgtggat ggccgcgttc tggtggtgat agttaccttt ggcataattc    720 
               
               
                   
               
               
                 tccctctgtg tctcttgaag aacttagggt atcttggcta tactagtgga ttttccttga    780 
               
               
                   
               
               
                 gctgtatggt ttttttccta attgtggtta tttacaagaa atttcaaatt ccctgcattg    840 
               
               
                   
               
               
                 ttccagagct aaattcaaca ataagtgcta attcaacaaa tgctgacacg tgtacgccaa    900 
               
               
                   
               
               
                 aatatgttac cttcaattca aagaccgtgt atgctttacc caccattgca tttgcatttg    960 
               
               
                   
               
               
                 tttgccaccc gtcagtcctg ccaatttaca gtgagcttaa agaccgatca cagaaaaaaa   1020 
               
               
                   
               
               
                 tgcagatggt ttcaaacatc tcctttttcg ccatgtttgt tatgtacttc ttgactgcca   1080 
               
               
                   
               
               
                 tttttggcta cttgacattc tatgacaacg tgcagtccga cctccttcac aaatatcaga   1140 
               
               
                   
               
               
                 gtaaagatga cattctcatc ctgacagtgc ggctggctgt cattgttgct gtgatcctca   1200 
               
               
                   
               
               
                 cagtgccggt gttatttttc acggttcgtt catctttatt tgaactggct aagaaaacaa   1260 
               
               
                   
               
               
                 agtttaattt atgtcgtcat accgtggtta cctgcatact cttggttgtt atcaacttgt   1320 
               
               
                   
               
               
                 tggtgatctt cataccctcc atgaaggata tttttggagt cgtaggagtt acatctgcta   1380 
               
               
                   
               
               
                 acatgcttat tttcattctt ccttcatctc tttatttaaa aatcacagac caggatggag   1440 
               
               
                   
               
               
                 ataaaggaac tcaaagaatt tgggctgccc ttttcttggg cctgggggtg ttgtctcctt   1500 
               
               
                   
               
               
                 gtcagcattc ccttgtcatc tatgactggg cctgctcatc gagtagtgac gaaggccact   1560 
               
               
                   
               
               
                 gaacccgccg agaaaaagaa acatccctgt tgtctgctca gtcaagtccc cacacatcag   1620 
               
               
                   
               
               
                 caatctctca ccacttcttt tgcaagttta cagaagcaaa cagaaatgta caggatactt   1680 
               
               
                   
               
               
                 aaaatggaat aactttttgg ttgcaaaaca gagacatggt tctataatgc ttcatgtccc   1740 
               
               
                   
               
               
                 tccaagattt gagatcaatt tagggattgt gaattttttt tttcaaattt catacaatca   1800 
               
               
                   
               
               
                 tatttcccag tacttttcac aatcattttt tacccatcta actctatgtt ttgtggcttc   1860 
               
               
                   
               
               
                 ccggtctctt agaactttga aaacatgata tacaataatg tttatttatt atacatccag   1920 
               
               
                   
               
               
                 attctgaaat aattttccta ctgatggtca actctaaaaa aaaaaaaaaa              1970 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 42 
               
               
                 &lt;211&gt; LENGTH: 412 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 42 
               
               
                   
               
               
                 Met Ser Val Phe Asn Leu Ser Asn Ala Ile Met Gly Ser Gly Ile Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Gly Leu Ala Phe Ala Leu Ala Asn Thr Gly Ile Leu Leu Phe Leu Val 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Leu Thr Ser Val Thr Leu Leu Ser Ile Tyr Ser Ile Asn Leu Leu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Ile Cys Ser Lys Glu Thr Gly Cys Met Val Tyr Glu Lys Leu Gly 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Glu Gln Val Phe Gly Thr Thr Gly Lys Phe Val Ile Phe Gly Ala Thr 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ser Leu Gln Asn Thr Gly Ala Met Leu Ser Tyr Leu Phe Ile Val Lys 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Asn Glu Leu Pro Ser Ala Ile Lys Phe Leu Met Gly Lys Glu Glu Thr 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Phe Ser Ala Trp Tyr Val Asp Gly Arg Val Leu Val Val Ile Val Thr 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Phe Gly Ile Ile Leu Pro Leu Cys Leu Leu Lys Asn Leu Gly Tyr Leu 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Gly Tyr Thr Ser Gly Phe Ser Leu Ser Cys Met Val Phe Phe Leu Ile 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Val Val Ile Tyr Lys Lys Phe Gln Ile Pro Cys Ile Val Pro Glu Leu 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Asn Ser Thr Ile Ser Ala Asn Ser Thr Asn Ala Asp Thr Cys Thr Pro 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Lys Tyr Val Thr Phe Asn Ser Lys Thr Val Tyr Ala Leu Pro Thr Ile 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Ala Phe Ala Phe Val Cys His Pro Ser Val Leu Pro Ile Tyr Ser Glu 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Leu Lys Asp Arg Ser Gln Lys Lys Met Gln Met Val Ser Asn Ile Ser 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Phe Phe Ala Met Phe Val Met Tyr Phe Leu Thr Ala Ile Phe Gly Tyr 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Leu Thr Phe Tyr Asp Asn Val Gln Ser Asp Leu Leu His Lys Tyr Gln 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Ser Lys Asp Asp Ile Leu Ile Leu Thr Val Arg Leu Ala Val Ile Val 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Ala Val Ile Leu Thr Val Pro Val Leu Phe Phe Thr Val Arg Ser Ser 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Leu Phe Glu Leu Ala Lys Lys Thr Lys Phe Asn Leu Cys Arg His Thr 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Val Val Thr Cys Ile Leu Leu Val Val Ile Asn Leu Leu Val Ile Phe 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Ile Pro Ser Met Lys Asp Ile Phe Gly Val Val Gly Val Thr Ser Ala 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Asn Met Leu Ile Phe Ile Leu Pro Ser Ser Leu Tyr Leu Lys Ile Thr 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 Asp Gln Asp Gly Asp Lys Gly Thr Gln Arg Ile Trp Ala Ala Leu Phe 
               
               
                     370                 375                 380 
               
               
                   
               
               
                 Leu Gly Leu Gly Val Leu Ser Pro Cys Gln His Ser Leu Val Ile Tyr 
               
               
                 385                 390                 395                 400 
               
               
                   
               
               
                 Asp Trp Ala Cys Ser Ser Ser Ser Asp Glu Gly His 
               
               
                                 405                 410 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 43 
               
               
                 &lt;211&gt; LENGTH: 812 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 43 
               
               
                   
               
               
                 gaacatggcg cgcggaaccg gcgcgcgcgc ctagctggcg ggaccgttag atcgaggcgg     60 
               
               
                   
               
               
                 atgcggcccg gaccccgtgg atatggagca gtcgccgccg ctggcgccgg agcccaccca    120 
               
               
                   
               
               
                 agggccaacc accgcaagga gctgaaggcg gcgggagccc gagtcgccgc cggcgtcggt    180 
               
               
                   
               
               
                 gccgtcaaag aagatggcca gggagacagc agcgtggtca gagtggtagg agctggccat    240 
               
               
                   
               
               
                 cggtgagagc tgctccatgc ctggctgctg ggttctagag cttgtggacc actggcttgc    300 
               
               
                   
               
               
                 ctcactgtgg ttggtggtgg cggtgacaga gtgtgcagca cgaccagagt ggcttttctg    360 
               
               
                   
               
               
                 gctttgccgc ccagctgctc catgccagga ggaggaggag acacctagag cctgcgacac    420 
               
               
                   
               
               
                 catggctcgc ctcgctgcag gttctaccca tgtaacagat gaggaaacca aggagcacag    480 
               
               
                   
               
               
                 ttatttacta actcgcacaa ggttcgaggc cgagctcaga cctgtggagc agaagctgag    540 
               
               
                   
               
               
                 tgcgctgcag tccccgctgg cccagaggcc cttcttcgag gtgccctcac ccctgggcgc    600 
               
               
                   
               
               
                 cgtggacctg tacgagtatg catgcgggga tgaggacctg gagccactgt gacgccaccc    660 
               
               
                   
               
               
                 atgagaacgc cgctgcgggg ccgctccaca cgtgccacgg ccaccactgg gacaccgccg    720 
               
               
                   
               
               
                 cttgtgtaaa aactgttgtc ttttgtggaa aatgagtgtg tttgcatgga atgataaatt    780 
               
               
                   
               
               
                 tttatttatt cacaaaaaaa aaaaaaaaaa aa                                  812 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 44 
               
               
                 &lt;211&gt; LENGTH: 131 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 44 
               
               
                   
               
               
                 Met Pro Gly Cys Trp Val Leu Glu Leu Val Asp His Trp Leu Ala Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Leu Trp Leu Val Val Ala Val Thr Glu Cys Ala Ala Arg Pro Glu Trp 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Phe Trp Leu Cys Arg Pro Ala Ala Pro Cys Gln Glu Glu Glu Glu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Thr Pro Arg Ala Cys Asp Thr Met Ala Arg Leu Ala Ala Gly Ser Thr 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 His Val Thr Asp Glu Glu Thr Lys Glu His Ser Tyr Leu Leu Thr Arg 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Thr Arg Phe Glu Ala Glu Leu Arg Pro Val Glu Gln Lys Leu Ser Ala 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Leu Gln Ser Pro Leu Ala Gln Arg Pro Phe Phe Glu Val Pro Ser Pro 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Leu Gly Ala Val Asp Leu Tyr Glu Tyr Ala Cys Gly Asp Glu Asp Leu 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Glu Pro Leu 
               
               
                     130 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 45 
               
               
                 &lt;211&gt; LENGTH: 1533 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (360) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 45 
               
               
                   
               
               
                 ggattgaatt ctagaccagc ggccgcaggt ccgaagctca acggctctga gaagttgagc     60 
               
               
                   
               
               
                 tcccactggc tctaactgac ccaaagggat gtcagtggtg ttctggcttt ctggaaggcc    120 
               
               
                   
               
               
                 atcaaagtca ggcttcttcg ggcccccgag gcaggaaatg gggtctctcc atgggagaca    180 
               
               
                   
               
               
                 ggatgctgag gccgcggaaa gtcagcctcc tcacccccca ggtacgaggc caggaagggg    240 
               
               
                   
               
               
                 acgtcctcac caatgctggg tcccagctcc agcagcacgt cttctcggcc cagcttggtt    300 
               
               
                   
               
               
                 agcagctcga gcagtctgcc tacagaagcg ccaggggcct ccctgccagg cgtccagcan    360 
               
               
                   
               
               
                 cctgccagtt gggtccgctt gtgtctccag ttgccggatc tccaagttac tcaaagtcca    420 
               
               
                   
               
               
                 tctcctccgc cagcgcggtc aagtcggccg ccacctgtgt ccgctcgttc aagaacagag    480 
               
               
                   
               
               
                 acaggcggcg ccgcactcgc atgttgagag cagccagggg aagggaggat gtggaggaga    540 
               
               
                   
               
               
                 ccggggccgc agaccccgcg ccgggacctc ctgcagccat ggcgggcggt cctggagcct    600 
               
               
                   
               
               
                 cagcgcggtc gggtcgcatt gtctgccagc gcttcctctt tctcctgcgg cacccgcccc    660 
               
               
                   
               
               
                 gccccgccgg ctttcgcttt ccgagaagcg ccgccctgcc ctacaatctg gagccccgag    720 
               
               
                   
               
               
                 caaaagtgcg gaggcggggg tgcccacctc tacccttgag gtctcgaggc gggtgatgtg    780 
               
               
                   
               
               
                 gggggcgtaa gaagtaggaa tctgcctttt gagatctgga gaggtccacg gcaccgccct    840 
               
               
                   
               
               
                 cgaaggtctg gtgatggtgc tagtaggttg gcggcggagt gaggacaccc tccttcgggg    900 
               
               
                   
               
               
                 gttgtaggaa acgggccttg ctttttggga tctggtggag ccacagttct tccaccgaag    960 
               
               
                   
               
               
                 aatctgaggg gttcatacgg tcctgccctc caggatggcg aggaggggac aagtgggaag   1020 
               
               
                   
               
               
                 gcaccactct gccctccacc gtctcttggg gaacacacaa tcctgccagt agggtatggg   1080 
               
               
                   
               
               
                 aagaccctgc tgtgctcccc aagtgggagt ggaaacgaac actgccttct gagcgtgagc   1140 
               
               
                   
               
               
                 atgccgtggc cctgccctcg aaatggttgg ggatgtcatg acactaggtt ggggagcaca   1200 
               
               
                   
               
               
                 aggcaccctg tcctttggtg tctgtggaaa gcccagcact actctccagg gtctcaggtg   1260 
               
               
                   
               
               
                 aagacatggc cctgctattg ggagtccaag ggggcacgtg gccttgccct ttaggtttag   1320 
               
               
                   
               
               
                 ggacacagtc ctgacctggg gagccctggt tcattcattt actcattcga caagtactta   1380 
               
               
                   
               
               
                 ttgattatct actaagtgtc aagggtgtcg caggctcccc ggaaaaatgg aacctttttg   1440 
               
               
                   
               
               
                 ccttggtgga gaccccagcc tagcacggga aatgggcact aataaaatca tttccaattg   1500 
               
               
                   
               
               
                 ggtgtaaaac tggtaaaaaa aaaaaaaaaa aaa                                1533 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 46 
               
               
                 &lt;211&gt; LENGTH: 233 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: UNSURE 
               
               
                 &lt;222&gt; LOCATION: (91) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 46 
               
               
                   
               
               
                 Met Ser Val Val Phe Trp Leu Ser Gly Arg Pro Ser Lys Ser Gly Phe 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Phe Gly Pro Pro Arg Gln Glu Met Gly Ser Leu His Gly Arg Gln Asp 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ala Glu Ala Ala Glu Ser Gln Pro Pro His Pro Pro Gly Thr Arg Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gly Arg Gly Arg Pro His Gln Cys Trp Val Pro Ala Pro Ala Ala Arg 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Leu Gly Pro Ala Trp Leu Ala Ala Arg Ala Val Cys Leu Gln Lys 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Arg Gln Gly Pro Pro Cys Gln Ala Ser Ser Xaa Leu Pro Val Gly Ser 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ala Cys Val Ser Ser Cys Arg Ile Ser Lys Leu Leu Lys Val His Leu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Leu Arg Gln Arg Gly Gln Val Gly Arg His Leu Cys Pro Leu Val Gln 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Glu Gln Arg Gln Ala Ala Pro His Ser His Val Glu Ser Ser Gln Gly 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Lys Gly Gly Cys Gly Gly Asp Arg Gly Arg Arg Pro Arg Ala Gly Thr 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Ser Cys Ser His Gly Gly Arg Ser Trp Ser Leu Ser Ala Val Gly Ser 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 His Cys Leu Pro Ala Leu Pro Leu Ser Pro Ala Ala Pro Ala Pro Pro 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Arg Arg Leu Ser Leu Ser Glu Lys Arg Arg Pro Ala Leu Gln Ser Gly 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Ala Pro Ser Lys Ser Ala Glu Ala Gly Val Pro Thr Ser Thr Leu Glu 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Val Ser Arg Arg Val Met Trp Gly Ala 
               
               
                 225                 230 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 47 
               
               
                 &lt;211&gt; LENGTH: 3023 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 47 
               
               
                   
               
               
                 tcacattgcc aaaagacggc aatatggtgg aaaataacat atagacaaac gcacaccggc     60 
               
               
                   
               
               
                 cttattccaa gcggcttcgg ccagtaacgt tagaattgcc gagaagtcat gataatttcg    120 
               
               
                   
               
               
                 tttgttcttc cagatttagg catatactta tttaatcaat aatgtgttaa cagctgacac    180 
               
               
                   
               
               
                 ctgtggttgc tgtgacaggc actatttgaa gtgctttatc atggattaac tcttaatcct    240 
               
               
                   
               
               
                 cagctaccgt ataaagtagg acataacccc atttcacatg cactacactg agacttgcct    300 
               
               
                   
               
               
                 cctctccccc cacattgaag atgttctttt ttcataacta tatactattc cattgcatga    360 
               
               
                   
               
               
                 atattctgta atttatttaa tcccctatgg attgataatt aggttcatta tagatagaag    420 
               
               
                   
               
               
                 tgtaattaac attcctgtac atgtattttg ctacttgtgt gggtatttct gtaggatgaa    480 
               
               
                   
               
               
                 taactagaaa tttattggat caggtttcac atttgcagtt ttgaaaacta ctaccaaaaa    540 
               
               
                   
               
               
                 gatttcacca atttacaact ccatcattag taagaatgcc tgtttgccta tagtctgcca    600 
               
               
                   
               
               
                 accctgaatc cttaaaaatt tttgccaatc tggtaggcaa aatttctttc ttttctttga    660 
               
               
                   
               
               
                 atattaatga ggaggaacat cttttcatgt ttcttggcca tttgcatttc ctattatgaa    720 
               
               
                   
               
               
                 ttgcttttgc ccattttcct ttttttaatt atgaaagtct aatgactacc ttctcattgt    780 
               
               
                   
               
               
                 ataaaaaaca cagttctttg aatagagaga cccttttctc caatgctacc aatcacattc    840 
               
               
                   
               
               
                 cacttaccac agtttaacat acatcctcta gtcacctttc cgtacgaata tacatacaca    900 
               
               
                   
               
               
                 taaaaacact ttttacataa ataggatctc atattctgta gctttttaaa attttggtct    960 
               
               
                   
               
               
                 caaaaaaaga taacaggtct ttaaatttct ttaatggttg actatgatta aatactatga   1020 
               
               
                   
               
               
                 aaatgccatt atttattccc ttaatttttt tccctctcgc tattacattg ccaaagttaa   1080 
               
               
                   
               
               
                 catcctattc agatgtcttt gtgcatgtgt gtgaatattt ctttagtctg gagtccagta   1140 
               
               
                   
               
               
                 aggtggattt ttggatcaaa gggtttgttc tctgtccacc ttcagtcttc ccaaaggcct   1200 
               
               
                   
               
               
                 tcataactgt attttcacca agtgtatgga gaatgttcat ttccccatat aaccatacct   1260 
               
               
                   
               
               
                 acacttgata gtttttatct gttgggcgaa aaagaacctt ttcttatttt gcatttccct   1320 
               
               
                   
               
               
                 gattataaaa aaaaatggtg agattggggt tattttcatg tttattggcc atttatagtt   1380 
               
               
                   
               
               
                 tactgtggat tgtttgtatc ccttacctgc tttctattgg gttatgtgtg gatatattgt   1440 
               
               
                   
               
               
                 ttttatttgt tcagcatctc cttccccatc ttctggtaac acaaccttta tttatttgtg   1500 
               
               
                   
               
               
                 gggaacctat tccctgtggc ttaggtgagc atgtgaccag gcctggcctc ctgagtccca   1560 
               
               
                   
               
               
                 cagcttccta gccacagtga taaaagaatg ggtatataac ttaagccagg ctaaggaaag   1620 
               
               
                   
               
               
                 cccttaacag aacttctgct ggaactactg gaaagaaggc tttatggaga tcccaggaac   1680 
               
               
                   
               
               
                 caaggaccat gtaagcctga atttgtgcca tgtggagaga gtctgtctga ggagaaactc   1740 
               
               
                   
               
               
                 ggatgctagc agaaatggaa agagaactaa gttctgatgt catttttctg gaggccctag   1800 
               
               
                   
               
               
                 atccagctgt gcctaaagcc tgccctacct ccggacttta aagttttgtg agccaataaa   1860 
               
               
                   
               
               
                 gtccctttct tgtttaagat aattgaattg agtttctgtt ctgattaata taggttatgt   1920 
               
               
                   
               
               
                 gtattttctt attgatttgt agaaaacctt gtaattttaa attctagact ttatgcccta   1980 
               
               
                   
               
               
                 tataagttac taaactctgt ctcaataaaa aaaaaggaaa acccacagcc aacattatca   2040 
               
               
                   
               
               
                 ctagtggtaa cagggaaaat gtcccctttg acccccaccc caagtacaga acatgcaagg   2100 
               
               
                   
               
               
                 acgcctgttc tcactgcatg tcttctgtgt tgtactgaag ctcctagctg gtgcagtgag   2160 
               
               
                   
               
               
                 gcaagacaaa gaaaggaaat ataggtgcac tgggaaggaa gaagaaacac tgcctttatt   2220 
               
               
                   
               
               
                 ctttaggtga catgattgtg tgcttttaaa ataataaagg aatcaacaga aaagttgctt   2280 
               
               
                   
               
               
                 aacctaatga atgagtttat caaagtcaca agatacaagg tcagtataca aaaatcagtt   2340 
               
               
                   
               
               
                 ggatttctac atggtagaaa caactgtaca tggaaaaatg tttaatagtg taagatatgt   2400 
               
               
                   
               
               
                 acattggaaa ctatgaaaga gtgtaaaaaa taaagaagtg aaataaatgg agaagatacc   2460 
               
               
                   
               
               
                 accttgatgg atggaagcct taaggtaaag atgctcattc tccccacact gacctgtaca   2520 
               
               
                   
               
               
                 ttccccacag gcctaatcaa aacccccaca ggcttctgtg tagaaattga catgctgatc   2580 
               
               
                   
               
               
                 ctgaaattta tatgaaaatg caaagagtct ggaataacca aaataatttt gtaaaagaac   2640 
               
               
                   
               
               
                 aaagaagact tctactacct ggttataaga cttctctgaa gcacagaagt caaggcagtg   2700 
               
               
                   
               
               
                 tggtggtggc ataagtaatg taaatcatcc aggtgtggtg gctcaggcca gtcatccagc   2760 
               
               
                   
               
               
                 actttgggag gctgaggcag gagaatcgct agagcccagg agttggaaac cagcctgggc   2820 
               
               
                   
               
               
                 agcatagcaa gactcatctc tacaaaaaat acgaaacaat tagctgggtg tctgtagcac   2880 
               
               
                   
               
               
                 atgcctgtag tcccagctgc gcgggaggct gagctgggaa gatcacttta gcctgggaag   2940 
               
               
                   
               
               
                 tcaggggagc tgtgatcaca ccactgcact ccagcctggg caacagagca agaccccatc   3000 
               
               
                   
               
               
                 tcaaaaacaa aaaaaaaaaa aaa                                           3023 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 48 
               
               
                 &lt;211&gt; LENGTH: 83 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 48 
               
               
                   
               
               
                 Met Lys Met Pro Leu Phe Ile Pro Leu Ile Phe Phe Pro Leu Ala Ile 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Thr Leu Pro Lys Leu Thr Ser Tyr Ser Asp Val Phe Val His Val Cys 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Glu Tyr Phe Phe Ser Leu Glu Ser Ser Lys Val Asp Phe Trp Ile Lys 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gly Phe Val Leu Cys Pro Pro Ser Val Phe Pro Lys Ala Phe Ile Thr 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Val Phe Ser Pro Ser Val Trp Arg Met Phe Ile Ser Pro Tyr Asn His 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Thr Tyr Thr 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 49 
               
               
                 &lt;211&gt; LENGTH: 1049 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 49 
               
               
                   
               
               
                 gtaactatct ccatgtttgt ccttttctac ctcgtttttt caccactccc aaacataacc     60 
               
               
                   
               
               
                 tcccaatctt ttttgttagt ccggccgtca atttgtatag taccaatttc tgtaaattct    120 
               
               
                   
               
               
                 ctcaattcat tgaagatcgt agggttaaac ttttttgtgt gtgatttaaa cttacaaaca    180 
               
               
                   
               
               
                 agtgaagaag ctatcgttta tttcagacga ggctgtagtt taaataccaa aagagggaaa    240 
               
               
                   
               
               
                 ataaaaaaga acctttgtaa aatatatctg aacctaatgg tttgtacact ggagaatcgt    300 
               
               
                   
               
               
                 tctagatagt taccaattaa atataactcc gccagtgtaa gggtgtgagg tgcagttgtc    360 
               
               
                   
               
               
                 caggagacga ttttgtatag tatttttctt gtacattact tccagtaaat atttgaaaat    420 
               
               
                   
               
               
                 atattgaagt aaacttgatt ttttttttgt cacaagaaaa tattaagagt tattgttgca    480 
               
               
                   
               
               
                 gttctgatga gctgcaggtt ttttgaactc acttctggag gtgcagagcc acaaacgcac    540 
               
               
                   
               
               
                 tttcggggcc tagttttgct cgaatatgaa tttagatagg tatcaagctg taactaagac    600 
               
               
                   
               
               
                 aatatttgat aaatgttgga tgacatttaa tttaatggag catgtactta tttgcatttg    660 
               
               
                   
               
               
                 ctggcagttc aggcatagtt aaagtgagag ttctccgata tttcataata agtgggtctg    720 
               
               
                   
               
               
                 ccaaaaccca tgtattaaat aaattgtcca agtgaaactc gactaacttt ggcctttgtg    780 
               
               
                   
               
               
                 tatttcctga aggtaatatt gttaactgtt aataaatact tctgacacta catttaaatg    840 
               
               
                   
               
               
                 tttgcagatt ctgcaaacta attgctcatt gtaatgttga aataatttgg atatttcaca    900 
               
               
                   
               
               
                 ttgaaatgaa aagcctttct ctggagcatt ttagatttgc attttaaatg catgaaatgt    960 
               
               
                   
               
               
                 aattgattta tttgtaaaat tttaaatggg gttaataaac tcagaaaaaa aaaaaaaaaa   1020 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                     1049 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 50 
               
               
                 &lt;211&gt; LENGTH: 98 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 50 
               
               
                   
               
               
                 Met Phe Val Leu Phe Tyr Leu Val Phe Ser Pro Leu Pro Asn Ile Thr 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ser Gln Ser Phe Leu Leu Val Arg Pro Ser Ile Cys Ile Val Pro Ile 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ser Val Asn Ser Leu Asn Ser Leu Lys Ile Val Gly Leu Asn Phe Phe 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Val Cys Asp Leu Asn Leu Gln Thr Ser Glu Glu Ala Ile Val Tyr Phe 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Arg Arg Gly Cys Ser Leu Asn Thr Lys Arg Gly Lys Ile Lys Lys Asn 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Cys Lys Ile Tyr Leu Asn Leu Met Val Cys Thr Leu Glu Asn Arg 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ser Arg 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 51 
               
               
                 &lt;211&gt; LENGTH: 1707 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 51 
               
               
                   
               
               
                 cacacagctc ccggatgaag ataacagttg gtagaccaaa aggtgacctc gcttagtata     60 
               
               
                   
               
               
                 ttgaaaacac acaccacaca tcacacacag aactgaatca taccacgtgc tgcctatggg    120 
               
               
                   
               
               
                 acttcagtta ctgtttcctg agttactgtt tatccgctgg caatggtgtg atttgtctgg    180 
               
               
                   
               
               
                 atcagatccg tgctattccc caacccacct ccagataatg tgagaaaata gccatgtcag    240 
               
               
                   
               
               
                 tatgtaggaa ctctgatggt gctcagattt gtgtgttcaa tcaatgggct taaatcagca    300 
               
               
                   
               
               
                 aaatattatg cctaaagtaa atctgttctt aacaagggct ctaccactgc attttcacat    360 
               
               
                   
               
               
                 gtaccttcag ggggttatct tttttttttt cccctcctat tttaatcagc aaaatccata    420 
               
               
                   
               
               
                 ccaaaacaac gacaacaacg ccctcttaag ggaccaccct ttggtcaatc ataacatgct    480 
               
               
                   
               
               
                 gtttaaagca gctgtttaca ggatgtgtag tggtatgccc ttgtcatata ctcttagcat    540 
               
               
                   
               
               
                 atcttttttt cctttggctt tgcatggctt tcttcaggta ctgtctcggt atcattctgc    600 
               
               
                   
               
               
                 taatcattgt tacagaatgg tgacttcatt tgtgctaaca gtacaacagc agatttgggt    660 
               
               
                   
               
               
                 caggcttaat ctagtgttaa cttttttttc tggtgctttt ttggattgat gactgtctca    720 
               
               
                   
               
               
                 ctttgactat acccatgttt tgcatgcaat gactcatgca tggttttctt aactagctaa    780 
               
               
                   
               
               
                 tattaacaat ttattccata taaaaatgga attttgcaac atcctttaat aaggtgaggg    840 
               
               
                   
               
               
                 aagcatgaac ctcagacttc tggcactatt acatagtaag cacatgaagt agtttgataa    900 
               
               
                   
               
               
                 taaatagcag ttctagtact tcacatttca cccgtgtgtg caatgccttt ttctgggggg    960 
               
               
                   
               
               
                 tggggggtga gggaaaacct ggtagtgaat gtgtagttgg ggaataaaga aaagcactaa   1020 
               
               
                   
               
               
                 atcctgccct ttttgtgtgg tttccttttg atacaactag gttattcata atgtatacct   1080 
               
               
                   
               
               
                 agaaaagtga aattgaaaat accaaaagat gtatcatttt tatttgaatc catcatgcag   1140 
               
               
                   
               
               
                 tgtacatttc agataatttc cttcagtctc cagataggag tgtatccaaa catctaattt   1200 
               
               
                   
               
               
                 tatgtgcact gtgtatctta tatgaatgtt ttattttata taccacatgc aaaaatgtcc   1260 
               
               
                   
               
               
                 atatgcacta tttaaatgtt ttaaataata tattccttct ttataatgct aaatctatat   1320 
               
               
                   
               
               
                 gagtaccata tttttataag tcagtggtct gactggtttc attttagaat taacagctgc   1380 
               
               
                   
               
               
                 ttcaatatgt tattcaatgt taatgtttgg ctgtgagtag aatatgtaaa agtggcatgg   1440 
               
               
                   
               
               
                 cagcacttat gctctgtgac agtattgtgt gtcatagttg agcagtagct ggtagaatta   1500 
               
               
                   
               
               
                 ggcagttggt gatagtttta ctttggtaca aataaaaact gtatatctat atacaaataa   1560 
               
               
                   
               
               
                 tatatagata tatatgtcca ccagtataat ggcattgctg tgtctggcac ttcattgtac   1620 
               
               
                   
               
               
                 ggacttttat aataaaagaa cttgaaagtt tttaaaaaaa aaaaaaaaaa aaaaaaaaaa   1680 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aaaaaaa                                       1707 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 52 
               
               
                 &lt;211&gt; LENGTH: 141 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 52 
               
               
                   
               
               
                 Met Gly Leu Asn Gln Gln Asn Ile Met Pro Lys Val Asn Leu Phe Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Thr Arg Ala Leu Pro Leu His Phe His Met Tyr Leu Gln Gly Val Ile 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Phe Phe Phe Phe Pro Ser Tyr Phe Asn Gln Gln Asn Pro Tyr Gln Asn 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Asn Asp Asn Asn Ala Leu Leu Arg Asp His Pro Leu Val Asn His Asn 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Met Leu Phe Lys Ala Ala Val Tyr Arg Met Cys Ser Gly Met Pro Leu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ser Tyr Thr Leu Ser Ile Ser Phe Phe Pro Leu Ala Leu His Gly Phe 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Leu Gln Val Leu Ser Arg Tyr His Ser Ala Asn His Cys Tyr Arg Met 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Val Thr Ser Phe Val Leu Thr Val Gln Gln Gln Ile Trp Val Arg Leu 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Asn Leu Val Leu Thr Phe Phe Ser Gly Ala Phe Leu Asp 
               
               
                     130                 135                 140 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 53 
               
               
                 &lt;211&gt; LENGTH: 1922 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 53 
               
               
                   
               
               
                 aaagcaccag gaactggttg accacctttc ccagcatgtc tcttaggggc ctgacctcag     60 
               
               
                   
               
               
                 gatttcagac tggattcact gtgacagaac taagggaata aatacatttt atgtccacgt    120 
               
               
                   
               
               
                 tcccactctg gtgtaccatc tgtccacaga ggggagagaa caagcaagag gttggggtgt    180 
               
               
                   
               
               
                 gccatccagt gtcccctgga gcagaccttg gcctctggtc ttcagtgccc ggtcctcctg    240 
               
               
                   
               
               
                 tctgttgtct ggcctggtga ggaagccctg acttgtaact ctcaaagcct aacttcaggg    300 
               
               
                   
               
               
                 gttgccctgc cagtgccctc tccgggagct ttgggtccct ggttataagc tttcagttct    360 
               
               
                   
               
               
                 cagtgtctgc tgtcaccagt aaccaagtgc tgaaaatgat ctgtaccact ttgctgacaa    420 
               
               
                   
               
               
                 gggcggctgg gccagggtgc ccccgcccag cttcctctac tctccctgtg gcctggggct    480 
               
               
                   
               
               
                 acacttgggt taaaactccc cattatggag ccaactgatt ctcccacttg gccccagggc    540 
               
               
                   
               
               
                 atgatttaag caaacttaaa actcaatgct ttattgatag tttaaataat taacattacg    600 
               
               
                   
               
               
                 taaagaaaaa tctaaatgta aacagttttt gcaaacgagt atccattaag ggacttccaa    660 
               
               
                   
               
               
                 gtacctaacc cctattaaac aatttatgta aaccactctt ccttaaagaa aatcgaatgc    720 
               
               
                   
               
               
                 ccagctcctt cccaatcctc caagctctga agtagggaag aggtgcagct aggagcagat    780 
               
               
                   
               
               
                 ggggcagtgt gtgtgttgga ggtggaggag tgggggaaat caaatcagct cacctgtgtg    840 
               
               
                   
               
               
                 gttatttatc agtgaaactt aataaactgg tactgggaaa gaaaaggagg ctagtgattg    900 
               
               
                   
               
               
                 acagcatccc gggctgctga gaggaccagc atgatgagct gtcttggagt tggcaattag    960 
               
               
                   
               
               
                 gagctcgtga gcgacctttg ccagaacagt tccatgggac gacctggctg gaggcctaat   1020 
               
               
                   
               
               
                 tgcaacagat ttatgatctt gcttggccag atatcctggg aggcagaaac gaggactgtt   1080 
               
               
                   
               
               
                 ctgaacatat gcatcaggac gcataatggg gctttgttcg ggcctgggca gacatggagg   1140 
               
               
                   
               
               
                 gcaatgcctg agctctcttc cagtttatct ccacgtcctc caagctcaaa tctggcagcc   1200 
               
               
                   
               
               
                 ctggagtggt ttgaagttga aactccacag agcagtggac ttaatgctcc aaagatgcgt   1260 
               
               
                   
               
               
                 tgacattcag ccattgtccc tggcccccaa gtgtccgtgg gagttgctga gttttcatgg   1320 
               
               
                   
               
               
                 agatgatcca cgtccctggg tgtcgcctgc ttcctctcac agtgtgaaaa ccacacagct   1380 
               
               
                   
               
               
                 actgttacta gagatcatcc tggaatttct gggacagccc ttgtttaaag cactctgtgt   1440 
               
               
                   
               
               
                 tccagattga tcagacacgt ctctctccac cccttcacaa aactccacta aaaagagtga   1500 
               
               
                   
               
               
                 gaaattttaa agggtgcaca ttcacaacta cagagagaat gaaaaagatg tcagtgaaga   1560 
               
               
                   
               
               
                 agagattatg cattctgggg caatggaaag cggatagagg ctgggcacag tggctcactc   1620 
               
               
                   
               
               
                 ctgtattccc agcactttgg gagcccaagg caggcggatc acctgaggtc agaagttcaa   1680 
               
               
                   
               
               
                 gaccagcctg gccaacgtgg tgaaacccca tctctacaaa aatacaaaaa ttagctgggc   1740 
               
               
                   
               
               
                 atggtggtgg gtacctgtag tcccagctac tcaggaggct gaggctactc gggaatcaca   1800 
               
               
                   
               
               
                 tgaacccaag aggcggaggt tgcagtgagc aggtatcacg ccaatgcacc ccagcctggg   1860 
               
               
                   
               
               
                 caacaaagcg agaatctgtc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1920 
               
               
                   
               
               
                 aa                                                                  1922 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 54 
               
               
                 &lt;211&gt; LENGTH: 114 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 54 
               
               
                   
               
               
                 Met Gly Leu Cys Ser Gly Leu Gly Arg His Gly Gly Gln Cys Leu Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ser Leu Pro Val Tyr Leu His Val Leu Gln Ala Gln Ile Trp Gln Pro 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Trp Ser Gly Leu Lys Leu Lys Leu His Arg Ala Val Asp Leu Met Leu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gln Arg Cys Val Asp Ile Gln Pro Leu Ser Leu Ala Pro Lys Cys Pro 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Trp Glu Leu Leu Ser Phe His Gly Asp Asp Pro Arg Pro Trp Val Ser 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Pro Ala Ser Ser His Ser Val Lys Thr Thr Gln Leu Leu Leu Leu Glu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ile Ile Leu Glu Phe Leu Gly Gln Pro Leu Phe Lys Ala Leu Cys Val 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Pro Asp 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 55 
               
               
                 &lt;211&gt; LENGTH: 589 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 55 
               
               
                   
               
               
                 tttttccaca ctcagctttc ccctagcatg gacaagattt tcagccattt ttgccacata     60 
               
               
                   
               
               
                 tacattttta aggaaaaaag atttttctct gtaagaaagt tctggttatg ctgttttaaa    120 
               
               
                   
               
               
                 ggtgacttgt caggagttga gacttccctg ccggattcta ttttgaaagt aaatggtctt    180 
               
               
                   
               
               
                 ccctccttgt tccgattctg cgttcccatc gtcagacaac tttggagtat tagaaaccac    240 
               
               
                   
               
               
                 tgtatatatg tggaaagcca ggtcagccag actgttagat tggtgtgcac tcacctgaga    300 
               
               
                   
               
               
                 gatctggcag gttggatata tttatgtgta tttctccaca gtgcttgctt tgccctgttg    360 
               
               
                   
               
               
                 gtaaggattt taaataacca tgctcaaaag agctgttcta atctgcgttt tgcatgttaa    420 
               
               
                   
               
               
                 gtgttaatat caaacattct taacgtgctc gaggaattgc ttttaacatt ctactttgcc    480 
               
               
                   
               
               
                 agtttcttca ttagattaat tgacatgtat tatttaaatg accagtgatg ctttgtgcaa    540 
               
               
                   
               
               
                 ttatgaatgt tgaagattaa agtacatagt tactaaaaaa aaaaaaaaa                589 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 56 
               
               
                 &lt;211&gt; LENGTH: 130 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 56 
               
               
                   
               
               
                 Met Asp Lys Ile Phe Ser His Phe Cys His Ile Tyr Ile Phe Lys Glu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Lys Arg Phe Phe Ser Val Arg Lys Phe Trp Leu Cys Cys Phe Lys Gly 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Asp Leu Ser Gly Val Glu Thr Ser Leu Pro Asp Ser Ile Leu Lys Val 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Asn Gly Leu Pro Ser Leu Phe Arg Phe Cys Val Pro Ile Val Arg Gln 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Trp Ser Ile Arg Asn His Cys Ile Tyr Val Glu Ser Gln Val Ser 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gln Thr Val Arg Leu Val Cys Thr His Leu Arg Asp Leu Ala Gly Trp 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ile Tyr Leu Cys Val Phe Leu His Ser Ala Cys Phe Ala Leu Leu Val 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Arg Ile Leu Asn Asn His Ala Gln Lys Ser Cys Ser Asn Leu Arg Phe 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Ala Cys 
               
               
                     130 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 57 
               
               
                 &lt;211&gt; LENGTH: 1363 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 57 
               
               
                   
               
               
                 gtagtggact tgatcttcct taacacagaa gtgtcactgt cacaagcctt ggaggatgtt     60 
               
               
                   
               
               
                 agcaggggag gttctccttt tgctattgtc atcacccagc aacaccagat tcaccgctcc    120 
               
               
                   
               
               
                 tgcacagtca acatcatgtt tggaaccccg caagagcatc gcaacatgcc ccaagcagat    180 
               
               
                   
               
               
                 gccatggtgc tggtggccag aaattatgag cgttacaaga atgagtgccg ggagaaggaa    240 
               
               
                   
               
               
                 cgtgaggaga ttgccagaca ggcagccaag atggccgatg aagccatcct gcaggaaaga    300 
               
               
                   
               
               
                 gagagaggag gccctgagga gggagtgcgt gggggccacc ctccagccat ccagagcctc    360 
               
               
                   
               
               
                 atcaacctgc tggcagacaa caggtacctc actgctgaag agactgacaa gatcatcaac    420 
               
               
                   
               
               
                 tacctgcgag agggaaggag cggctgatga ggagcagcac cgactctctg cctggggagc    480 
               
               
                   
               
               
                 tacgtggcag ggccgaggcc cgatttcccg ccaaccactc ggggcgacct cgggtgcctc    540 
               
               
                   
               
               
                 gctgaagaca cagccaagct cccaaccgct ccagagcggc caagtgctcc cctctgctac    600 
               
               
                   
               
               
                 acccactcca tctgcacccc ccacctccca gcaagagctt caggccaaaa tcctcagcct    660 
               
               
                   
               
               
                 cttcaatagt ggcaccgtga cggccaatag cagctctgca tccccctcgg ttgctgccgg    720 
               
               
                   
               
               
                 aaacacccca aaccagaatt tttccacagc agcaaacagc cagcctcaac aaagatcaca    780 
               
               
                   
               
               
                 ggcttctggc aatcagcctc caagcatttt gggacaggga ggatctgctc agaacatggg    840 
               
               
                   
               
               
                 ccccagacct ggggctcctt cccaagggct ttttggccag ccttccagtc gcctggcacc    900 
               
               
                   
               
               
                 tgctagcaac atgactagcc agaggcctgt gtcttccaca ggtatcaact ttgacaatcc    960 
               
               
                   
               
               
                 aagtgtacag aaggctctgg ataccctgat ccagagtggc cctgctctct cccacctggt   1020 
               
               
                   
               
               
                 tagccagacc acagcacaga tggggcagcc acaggccccc atgggatctt accagaggca   1080 
               
               
                   
               
               
                 ttactgagag ctaaatcttt caactctccc cagtcccctc atcccctggc ctcctcccac   1140 
               
               
                   
               
               
                 ttacttgttc taaatagagc tgtttggagg atgttctctg cgctcccagg ccggcatcga   1200 
               
               
                   
               
               
                 gtgtcatcaa tttctaccac ctgctctctc ttctgcccaa ggctgtgttg cttattcctt   1260 
               
               
                   
               
               
                 acaaagttta tactgcattt ggggctgtat ctttttttgt tttttgtttt gtagaaaata   1320 
               
               
                   
               
               
                 aaaatctccg ggggcaaaaa aaaaaaaaaa aaaaaaaaaa aaa                     1363 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 58 
               
               
                 &lt;211&gt; LENGTH: 343 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 58 
               
               
                   
               
               
                 Met Leu Ala Gly Glu Val Leu Leu Leu Leu Leu Ser Ser Pro Ser Asn 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Thr Arg Phe Thr Ala Pro Ala Gln Ser Thr Ser Cys Leu Glu Pro Arg 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Lys Ser Ile Ala Thr Cys Pro Lys Gln Met Pro Trp Cys Trp Trp Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Glu Ile Met Ser Val Thr Arg Met Ser Ala Gly Arg Arg Asn Val Arg 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Arg Leu Pro Asp Arg Gln Pro Arg Trp Pro Met Lys Pro Ser Cys Arg 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Lys Glu Arg Glu Glu Ala Leu Arg Arg Glu Cys Val Gly Ala Thr Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Gln Pro Ser Arg Ala Ser Ser Thr Cys Trp Gln Thr Thr Gly Thr Ser 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Leu Leu Lys Arg Leu Thr Arg Ser Ser Thr Thr Cys Glu Arg Glu Gly 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Ala Ala Asp Glu Glu Gln His Arg Leu Ser Ala Trp Gly Ala Thr Trp 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Gln Gly Arg Gly Pro Ile Ser Arg Gln Pro Leu Gly Ala Thr Ser Gly 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Ala Ser Leu Lys Thr Gln Pro Ser Ser Gln Pro Leu Gln Ser Gly Gln 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Val Leu Pro Ser Ala Thr Pro Thr Pro Ser Ala Pro Pro Thr Ser Gln 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Gln Glu Leu Gln Ala Lys Ile Leu Ser Leu Phe Asn Ser Gly Thr Val 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Thr Ala Asn Ser Ser Ser Ala Ser Pro Ser Val Ala Ala Gly Asn Thr 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Pro Asn Gln Asn Phe Ser Thr Ala Ala Asn Ser Gln Pro Gln Gln Arg 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Ser Gln Ala Ser Gly Asn Gln Pro Pro Ser Ile Leu Gly Gln Gly Gly 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Ser Ala Gln Asn Met Gly Pro Arg Pro Gly Ala Pro Ser Gln Gly Leu 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Phe Gly Gln Pro Ser Ser Arg Leu Ala Pro Ala Ser Asn Met Thr Ser 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Gln Arg Pro Val Ser Ser Thr Gly Ile Asn Phe Asp Asn Pro Ser Val 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Gln Lys Ala Leu Asp Thr Leu Ile Gln Ser Gly Pro Ala Leu Ser His 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Leu Val Ser Gln Thr Thr Ala Gln Met Gly Gln Pro Gln Ala Pro Met 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Gly Ser Tyr Gln Arg His Tyr 
               
               
                             340 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 59 
               
               
                 &lt;211&gt; LENGTH: 1613 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 59 
               
               
                   
               
               
                 cctcgctaca caagaaaagt tgtgtcctgg tttaagcttt gactgaaact cattcacatc     60 
               
               
                   
               
               
                 cgtgtgttaa tttgcatttt caggcctctt ctctctgaat ctctcctaga gaagaaaatt    120 
               
               
                   
               
               
                 atggaatagt tggttgcttt ctgtttgggg tcaggagaat tagggagaga tttctctttg    180 
               
               
                   
               
               
                 tttccaatgg atcctgaagg tgagctgcca tcacctcatc tctaggaggt gctgtaggga    240 
               
               
                   
               
               
                 gaaaaactgg aggtagcagg gtatttctct ctcttttctc ccctccgtct agccttaatt    300 
               
               
                   
               
               
                 aatagtttca tcttttgggt catcgaaaaa gtcagctctg attcatccat atccaataaa    360 
               
               
                   
               
               
                 ttgcagggtc acatggatcg ggtcttccga gccacctgcc ttctttttct caagttccct    420 
               
               
                   
               
               
                 ggtggcgcct cttcaggtcc tcacatctct tctgtcccgt cacagaggaa cacctcagac    480 
               
               
                   
               
               
                 ccatcctctc taccttggca tatcaccccc tggtcccttg atgcttcttc cttctggtcc    540 
               
               
                   
               
               
                 tcggagtctt ttctgagctc cagcgtcacc ggcgttggtg gcctttccac cctcccctct    600 
               
               
                   
               
               
                 cgcatgtgcc ttttccagtc cattgggact actccctgct cccccgtcac acacgttccc    660 
               
               
                   
               
               
                 taggccagtt ccttttcacc tggctgtagt cctcatgacc agctaaaagt gcgcctgccc    720 
               
               
                   
               
               
                 cagatatttg tgatttccct ctcttcagag aaagcaggga gcccctggca tccctatctg    780 
               
               
                   
               
               
                 tgacaggtgc cacacccgcc ttacaatgca ggtctgtgtg cccttgttgt atccctaact    840 
               
               
                   
               
               
                 gctctcaaat cccttagtga cggcctcatt tctctgcctt tgtgtagcat ttaaacagtt    900 
               
               
                   
               
               
                 taaatggctg ggcacgtggc tcacatctct aatcccagca ctttggaagg ccaaggcggg    960 
               
               
                   
               
               
                 acgatcactg gagtctcggg gagttcgaga ccagcctggc caacatggtg aaaccccttt   1020 
               
               
                   
               
               
                 ctactaaaaa tacagaaatc ggcgggctgg ttggtgcgtt cctgtaatcc cggctactgg   1080 
               
               
                   
               
               
                 gggggctaag gagggagaat tgtttggacc cgggaggttg cagtgagcag agtatgcgtc   1140 
               
               
                   
               
               
                 attgcactcc agattgggga acaagagcga gactctgtct caaaataagt aagttgataa   1200 
               
               
                   
               
               
                 aagtgaacag tttaaatgga tgaacctttg accctgcagt aaattccaga catgtaggag   1260 
               
               
                   
               
               
                 aaacagccag gtgtagaggg aaggcagtgg ggttctgagt caggcagacc taagtttggc   1320 
               
               
                   
               
               
                 atctggctcc tgtgctggtg gctgagttcc ttaacctttg tgtgttctta cagctctgtg   1380 
               
               
                   
               
               
                 ggtctcaatt gttccaccta taaaacaggg atgacactgt gacctttcag ggttgtggag   1440 
               
               
                   
               
               
                 tagttgtgtg atgttccttg tttaggccag gcccagtggc tcacgcctgt aatcccaata   1500 
               
               
                   
               
               
                 ctttgggaag ccaaggtgag tggattgctt gagccccgta gtttgagacc agcctacaca   1560 
               
               
                   
               
               
                 acatggcaag accccatctc cgcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa          1613 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 60 
               
               
                 &lt;211&gt; LENGTH: 96 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 60 
               
               
                   
               
               
                 Met Asp Arg Val Phe Arg Ala Thr Cys Leu Leu Phe Leu Lys Phe Pro 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Gly Gly Ala Ser Ser Gly Pro His Ile Ser Ser Val Pro Ser Gln Arg 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Asn Thr Ser Asp Pro Ser Ser Leu Pro Trp His Ile Thr Pro Trp Ser 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Asp Ala Ser Ser Phe Trp Ser Ser Glu Ser Phe Leu Ser Ser Ser 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Val Thr Gly Val Gly Gly Leu Ser Thr Leu Pro Ser Arg Met Cys Leu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Phe Gln Ser Ile Gly Thr Thr Pro Cys Ser Pro Val Thr His Val Pro 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 61 
               
               
                 &lt;211&gt; LENGTH: 1700 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 61 
               
               
                   
               
               
                 aagctgtgcg aggagttcct ggcgcacgcc cgcggccggc tggagaagga gctgagaaac     60 
               
               
                   
               
               
                 ctggaggccg agctggggcc ctcacctccg gctcccgacg tgttagagtt caccgaccat    120 
               
               
                   
               
               
                 ggaggcagtg gcttcgtggg cggcctctgc caggtggcgg cggcctacca ggagctgttt    180 
               
               
                   
               
               
                 gcggcccagg gcccagcagg tgccgagaag ctggcggcct tcgcccggca gctgggcagc    240 
               
               
                   
               
               
                 cgctattttg cgctggtgga gcggcggctg gcgcaggagc agggtggtgg tgacaactca    300 
               
               
                   
               
               
                 ctgctggtgc gggcgctgga ccgcttccac cggcgcttgc gggctcccgg ggccctgctg    360 
               
               
                   
               
               
                 gccgctgccg ggctcgcaga cgctgccacg gagatcgtgg aacgagtggc ccgcgagcgc    420 
               
               
                   
               
               
                 ctgggccacc acctgcaggg tctccgggcg gccttcctgg gctgcctgac agacgtccgc    480 
               
               
                   
               
               
                 caggcgctgg cagcacctcg cgtggctggg aaggagggcc ctggcctggc cgagttgctg    540 
               
               
                   
               
               
                 gccaatgtgg ccagctccat cctgagccac attaaggcct ctctggcagc agtgcacctt    600 
               
               
                   
               
               
                 ttcaccgcca aagaggtgtc cttctccaac aagccctact tccggggtga gttctgcagt    660 
               
               
                   
               
               
                 cagggtgtcc gtgagggcct catcgtgggc ttcgtccact ctatgttcca gacggctcag    720 
               
               
                   
               
               
                 agcttctgcg acagccctgg ggagaaaggg ggtgccacac cacctgccct gctcctgctg    780 
               
               
                   
               
               
                 ctctcccgcc tctgcctgga ctacgagacg gccaccatct cctacatcct cactctcact    840 
               
               
                   
               
               
                 gatgaacagt ttctggtgca ggatcagttc ccagtgacgc ccgtgagcac gctgtgtgca    900 
               
               
                   
               
               
                 gaggccaggg aaacggcgcg gcggctgctg acccatacgt gaagtgcagg gcctggtcat    960 
               
               
                   
               
               
                 atcacagatg ctgcgcaaga gcgtggagac tcgcgactgg ctcagcactc tggagccccg   1020 
               
               
                   
               
               
                 gaatgtgcgg gctgtcatga agcgggtggt ggaggatacc accgccatcg acgtgcaggt   1080 
               
               
                   
               
               
                 ggggctcctg tacgaagagg gtgttcgcaa ggcccagagc agcgactcca gcaagaggac   1140 
               
               
                   
               
               
                 tttctccgtg tacagcagct ctcggcagca gggccgctac gcccccagct atacccccag   1200 
               
               
                   
               
               
                 tgccccgatg gacaccaacc tcttgagcaa tatccagaag ctattctctg aacgtattga   1260 
               
               
                   
               
               
                 tgtgttcagc cctgtggagt tcaacaaggt gtcggtgctg accggcatca tcaagatcag   1320 
               
               
                   
               
               
                 cctgaagacg ctgctggagt gtgtgcggct gcgcaccttt gggcgcttcg ggctgcagca   1380 
               
               
                   
               
               
                 ggtgcaagtg gactgccact ttctgcagct ctacctgtgg cggttttgtg gccgacgaag   1440 
               
               
                   
               
               
                 aactcgtgca cttgctgctg gacgaagtgg tggcctctgc tgccctgcgc tgcccagacc   1500 
               
               
                   
               
               
                 ctgtgcccat ggagcccagt gtggttgagg tcatctgcga gcgcggctag gcgcagccgc   1560 
               
               
                   
               
               
                 tgccatgcac cggtctgtcc ctgcacccca tggcacccag gatctggtct cggtggtcct   1620 
               
               
                   
               
               
                 tccccgcagg caggtgtcag gaccggccta ataaacatgt gtggcctccc caaaaaaaaa   1680 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa                                               1700 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 62 
               
               
                 &lt;211&gt; LENGTH: 116 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 62 
               
               
                   
               
               
                 Met Glu Ala Val Ala Ser Trp Ala Ala Ser Ala Arg Trp Arg Arg Pro 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Thr Arg Ser Cys Leu Arg Pro Arg Ala Gln Gln Val Pro Arg Ser Trp 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Arg Pro Ser Pro Gly Ser Trp Ala Ala Ala Ile Leu Arg Trp Trp Ser 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gly Gly Trp Arg Arg Ser Arg Val Val Val Thr Thr His Cys Trp Cys 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gly Arg Trp Thr Ala Ser Thr Gly Ala Cys Gly Leu Pro Gly Pro Cys 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Trp Pro Leu Pro Gly Ser Gln Thr Leu Pro Arg Arg Ser Trp Asn Glu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Trp Pro Ala Ser Ala Trp Ala Thr Thr Cys Arg Val Ser Gly Arg Pro 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ser Trp Ala Ala 
               
               
                         115 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 63 
               
               
                 &lt;211&gt; LENGTH: 1616 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (869) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 63 
               
               
                   
               
               
                 tcttaatata tgcacatatg tatatgtaac acataaataa ttacatacat aatacaggaa     60 
               
               
                   
               
               
                 gacacagaaa taattacata catgatacag gaagacacag aaaaagagaa actggtctga    120 
               
               
                   
               
               
                 taccagaagt atcaactcag gaacaatttt ctactagctg agcctcagaa gcagcaactt    180 
               
               
                   
               
               
                 ttccaaagtg aagtgatgaa tggaggcgcc agccctcctc ctcaggttaa gaaaggcaaa    240 
               
               
                   
               
               
                 gagccctgct tttggctgta aaaagccagg ttccctaatc aggtgaaggc ctgaggcagg    300 
               
               
                   
               
               
                 gactccttag ggcagtgtaa ctagtagcca aggcacaggc tccaaaggga ggttgcctgg    360 
               
               
                   
               
               
                 gctcaagccc ggctctgcca cttcacagct gggtgtcccg gggtgagcct ctcagcccct    420 
               
               
                   
               
               
                 cgttcagcct cagttccaca tgtgtaaatg gaggtctagt agctacctca cagggcagtt    480 
               
               
                   
               
               
                 gttgaaaata agctaatgct cctaaaaccc tgagaacagt gctctgtgta tgataagtgt    540 
               
               
                   
               
               
                 tcatagacgt cacattattt atttattttg aaaattcttc ttttagtcaa acttataagt    600 
               
               
                   
               
               
                 tttctgtggc tcaaaatatt ctcaaccagg gtttctttag tggccatcag ctcccagggg    660 
               
               
                   
               
               
                 gtgatatcat ggaagctgtt atgcttagga atttgtttaa aaagacgtcc tgccctgtgc    720 
               
               
                   
               
               
                 cccagtacat ttcaacacca cccagccaca cagccgcctt ctggcccaac actcttaaag    780 
               
               
                   
               
               
                 acacagtgct tgggaaatgt cctcatgccc cctttcctga ggcaggtttg ccactgtttc    840 
               
               
                   
               
               
                 cccaggcctg gcagtcacag atggcagtna ctgacctgct gtggatttga gagatggaga    900 
               
               
                   
               
               
                 gaaaacctcc actcttctta ttctcccaat agctcagtct ctgcctcagt tccaatttcc    960 
               
               
                   
               
               
                 ctttggcgta actatgattg tcgtccaagg cccccctaga taggcaagac tcatgatacc   1020 
               
               
                   
               
               
                 caaggggtga tcaggggata gagatgagat gtctgggtgg atggcggaat ggggtatttt   1080 
               
               
                   
               
               
                 ctaactaatg gggtgcaggg gtacctgagc ctgctctcaa atgtgttata cccctaaaaa   1140 
               
               
                   
               
               
                 atgtttttaa ggtagtgggt tgatataaca gttgttaaga ccatgatgct agaggcaaga   1200 
               
               
                   
               
               
                 tcgtgagatc catggagaag gtagtggaag gggtagggcc tttattcaca tatatgctgc   1260 
               
               
                   
               
               
                 cttctccccc aactgatgtg atatccttta tattcgtgac tccagtgaac ccacgcctcg   1320 
               
               
                   
               
               
                 gaggatttac accctgtatt ggtactcctc ttgagtctgg gctggcctgt gactttaatc   1380 
               
               
                   
               
               
                 agtgcaaggc ggaagtgggt tcagtgccag ttctaagact acaaagagaa agaaaagttc   1440 
               
               
                   
               
               
                 aaccttccaa tatcccagca gacatcaggc cccagctgtg tcaccagctt cacgcccacg   1500 
               
               
                   
               
               
                 agtgaccaca acaaacccag cagaaccaac cagcgcatcc cagccctggt tgcagaatca   1560 
               
               
                   
               
               
                 tgagtaaata aaatggttgc tgttccaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa       1616 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 64 
               
               
                 &lt;211&gt; LENGTH: 97 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 64 
               
               
                   
               
               
                 Met Glu Lys Val Val Glu Gly Val Gly Pro Leu Phe Thr Tyr Met Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Pro Ser Pro Pro Thr Asp Val Ile Ser Phe Ile Phe Val Thr Pro Val 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Asn Pro Arg Leu Gly Gly Phe Thr Pro Cys Ile Gly Thr Pro Leu Glu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ser Gly Leu Ala Cys Asp Phe Asn Gln Cys Lys Ala Glu Val Gly Ser 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Val Pro Val Leu Arg Leu Gln Arg Glu Arg Lys Val Gln Pro Ser Asn 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ile Pro Ala Asp Ile Arg Pro Gln Leu Cys His Gln Leu His Ala His 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Glu 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 65 
               
               
                 &lt;211&gt; LENGTH: 937 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 65 
               
               
                   
               
               
                 gattgccgga agctgaaggg atgctttgaa cgtggggggg ctgcgtcaca gttggactcc     60 
               
               
                   
               
               
                 cacttgcaga ggacctgatt atgtccagtg accacctgaa caacagcaca ctgaaggagg    120 
               
               
                   
               
               
                 ctcagttcaa agacctgttc ttaaaaaaag cggagctgga gttcgcccaa atcatcatca    180 
               
               
                   
               
               
                 tcgtcgtggt ggtcacggtg atggtggtgg tcatcgtctg cctgctgaac cactacaaag    240 
               
               
                   
               
               
                 tctccacgcg gtccttcatc aaccgcccga accagagccg gaggcgggag gacgggctgc    300 
               
               
                   
               
               
                 cgcaggaagg gtgcctgtgg ccttcagaca gcgccgcacc gcgctggggc gcctcggaga    360 
               
               
                   
               
               
                 tcatgcatgc cccgcggtcc agggacaggt tcacagcgcc gtccttcatc cagagggatc    420 
               
               
                   
               
               
                 gcttcagccg cttccagccc acctacccct atgtgcagca cgagattgat cttcctccca    480 
               
               
                   
               
               
                 ccatctccct gtccgacggt gaagagccac ctccttacca ggggccctgc accctgcagc    540 
               
               
                   
               
               
                 tccgggaccc tgaacagcag atggaactca accgagagtc cgtgagggcc ccacccaacc    600 
               
               
                   
               
               
                 gaaccatatt tgacagtgat ttaatagaca ttgctatgta tagcgggggt ccatgcccac    660 
               
               
                   
               
               
                 ccagcagcaa ctcgggcatc agtgcaagca cctgcagcag taacgggagg atggaggggc    720 
               
               
                   
               
               
                 caccccccac atacagcgag gtgatgggcc accacccagg cgcctctttc ctccatcacc    780 
               
               
                   
               
               
                 agcgcagcaa cgcacacagg ggcagcagac tgcagtttca gcagaacaat gcagagagca    840 
               
               
                   
               
               
                 caatagtacc catcaaaggc aaagatagga agcctgggaa cctggtctga ttccttccaa    900 
               
               
                   
               
               
                 cgtgcacttc agctggagaa agaaaccaag aagggaa                             937 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 66 
               
               
                 &lt;211&gt; LENGTH: 269 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 66 
               
               
                   
               
               
                 Met Ser Ser Asp His Leu Asn Asn Ser Thr Leu Lys Glu Ala Gln Phe 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Lys Asp Leu Phe Leu Lys Lys Ala Glu Leu Glu Phe Ala Gln Ile Ile 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ile Ile Val Val Val Val Thr Val Met Val Val Val Ile Val Cys Leu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Asn His Tyr Lys Val Ser Thr Arg Ser Phe Ile Asn Arg Pro Asn 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gln Ser Arg Arg Arg Glu Asp Gly Leu Pro Gln Glu Gly Cys Leu Trp 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Pro Ser Asp Ser Ala Ala Pro Arg Trp Gly Ala Ser Glu Ile Met His 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ala Pro Arg Ser Arg Asp Arg Phe Thr Ala Pro Ser Phe Ile Gln Arg 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Asp Arg Phe Ser Arg Phe Gln Pro Thr Tyr Pro Tyr Val Gln His Glu 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Ile Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Pro Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Met Glu Leu Asn Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Phe Asp Ser Asp Leu Ile Asp Ile Ala Met Tyr Ser Gly Gly Pro Cys 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Pro Pro Ser Ser Asn Ser Gly Ile Ser Ala Ser Thr Cys Ser Ser Asn 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Gly Arg Met Glu Gly Pro Pro Pro Thr Tyr Ser Glu Val Met Gly His 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 His Pro Gly Ala Ser Phe Leu His His Gln Arg Ser Asn Ala His Arg 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Gly Ser Arg Leu Gln Phe Gln Gln Asn Asn Ala Glu Ser Thr Ile Val 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Pro Ile Lys Gly Lys Asp Arg Lys Pro Gly Asn Leu Val 
               
               
                             260                 265 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 67 
               
               
                 &lt;211&gt; LENGTH: 1467 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 67 
               
               
                   
               
               
                 ttttacaggt agaataaaca tagcatttcc ttctgtagac agaaggtgat atagttaacc     60 
               
               
                   
               
               
                 tcatgcactt tcatccacta agactccaag tcaaatgcca ccacactgca gcacacccaa    120 
               
               
                   
               
               
                 gagagcctgg tctacctgct tccaggagtt cacacgatgt acaggaaaag gcactaagta    180 
               
               
                   
               
               
                 aatttaactt tccattattt ttttttctgg agttatttct tattgtacaa agatttccag    240 
               
               
                   
               
               
                 acaactcctt ttccatttca ttcattgcca tttctgcttt atccagcagc acggagcctc    300 
               
               
                   
               
               
                 agctttgaga aatctcttga ccagagtgat ttttattttc ctcacacata aaatgtatgg    360 
               
               
                   
               
               
                 aaatggagat atctttttgg gcatatcagg gctatcatga gaagataaag ccatcaagct    420 
               
               
                   
               
               
                 gtaataatgg ttatgaaagc acttccaaca attctaaaga tgataaaaca gtggatgatc    480 
               
               
                   
               
               
                 cactgttgca caaaattcta gcaacaaatt ctaattcagc cacacttgtt cttaataaca    540 
               
               
                   
               
               
                 gattgctctg tttttcataa ttattctaca tattaatatc actgtgaagt cattacaaca    600 
               
               
                   
               
               
                 gctgtgtttt tttggtcaca gatgttttat tttcaaagaa aacaaaattg tgtacgtttt    660 
               
               
                   
               
               
                 tttccttgga gttctgattg aaccagtttt atatctaaag aaatacagaa atatctattc    720 
               
               
                   
               
               
                 ttgcctatcc atgatgtaca gccattatca aagtcttata agttaatctt ttttcaatca    780 
               
               
                   
               
               
                 tagtttattc cttttggtat taaaaaaatc ctatttacag acagtgcaaa actgatagaa    840 
               
               
                   
               
               
                 aagtaggaag agagaaaatt aaatagccaa ttagaaaaat actgtagaat tgcagttcca    900 
               
               
                   
               
               
                 gagtatggat aggatatcat agcaagctgt tgagtaaggc gaggaaggct tctctgagga    960 
               
               
                   
               
               
                 ggtgaccatc aactgagaga gggtttatag aatgagaaat gtaaggaata taaggaagct   1020 
               
               
                   
               
               
                 gtggtgcggg aaagaatatg tgcggcaaca agaggacaat actgtagggt tcgtagacca   1080 
               
               
                   
               
               
                 tcaatctggt accatttctg gagccattaa ttctttatat gagggtaagt ttaagacagg   1140 
               
               
                   
               
               
                 cttgtggctg ggcacagtgg ctcatgcctg taatcccagc actttggaag gccgaagcgg   1200 
               
               
                   
               
               
                 gctgatcacc tgaggtcagg aatttgagaa cagcctggcc aacatggtga cacccatctc   1260 
               
               
                   
               
               
                 tactaaatat acaaaattag ccgggtgtgg tggtgggagc ctgtaatccc agctactcgt   1320 
               
               
                   
               
               
                 aaggctgagg caggagaatt gcatgaaccc aggaggtgga ggttgcagtg agccgagatt   1380 
               
               
                   
               
               
                 gtgccactgt cccactgtcc tccagcctgg gccacagagt gatactctgc ctcaccaaaa   1440 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aaaaaaa                                       1467 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 68 
               
               
                 &lt;211&gt; LENGTH: 81 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 68 
               
               
                   
               
               
                 Met His Phe His Pro Leu Arg Leu Gln Val Lys Cys His His Thr Ala 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ala His Pro Arg Glu Pro Gly Leu Pro Ala Ser Arg Ser Ser His Asp 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Val Gln Glu Lys Ala Leu Ser Lys Phe Asn Phe Pro Leu Phe Phe Phe 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Glu Leu Phe Leu Ile Val Gln Arg Phe Pro Asp Asn Ser Phe Ser 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ile Ser Phe Ile Ala Ile Ser Ala Leu Ser Ser Ser Thr Glu Pro Gln 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 69 
               
               
                 &lt;211&gt; LENGTH: 1235 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 69 
               
               
                   
               
               
                 tttctccttt cctctccctg tgcctcatct tcctctcctc tctctctccc ttctctcttc     60 
               
               
                   
               
               
                 tccgtttctc tttttcaccc cactccttca tcttgtctcg ctgtctatat tgttttcctt    120 
               
               
                   
               
               
                 ctctgtatct tcattgcctt tgctttcttt caaactttct ccttcacaga tttttcttta    180 
               
               
                   
               
               
                 ttaatcagaa tcatactgac caacatgtgc tgaggacttt ctgtgtgctc tgtgcttcac    240 
               
               
                   
               
               
                 atacagtcat gtgcatcttt ccagttccac aagtgagtta tcctcatttc tcggggccat    300 
               
               
                   
               
               
                 agagctagtg agtgacagag ctaggttttg tatgtcaaag cctctgtcct acatgacatg    360 
               
               
                   
               
               
                 gcttttcctg ctgccttctc ccctggtatt cgtctccctc ttttctcctc tggctctgct    420 
               
               
                   
               
               
                 ggctctcctc tggctctgcg agggggtggt tttcagcctg ggcccttgca gatgtgtctg    480 
               
               
                   
               
               
                 tggcagcagg ccacacagac cgcagcgggc tgggcagcgt cctgagagac ctagtgaagc    540 
               
               
                   
               
               
                 caggcgacga gaaccttcgg gagatgaaca agaagctgca gaacatgctg gaggagcagc    600 
               
               
                   
               
               
                 tcaccaagaa tatgcacttg cacaaggata tggaagttct gtcccaggaa attgtgcggc    660 
               
               
                   
               
               
                 tcagcaagga gtgcgtgggg cctcctgacc cagacctaga gccaggagaa accagctaaa    720 
               
               
                   
               
               
                 gacctgcagg ctgcacccac ctcctcccct tcctaccccc taggatgcta tttcccttgg    780 
               
               
                   
               
               
                 gctgtggtgg aaaaatgagg gctggagcca aaatcaaata gcttgggaga ctggacatta    840 
               
               
                   
               
               
                 aaggggctag aggcctgatg gttagtgtta atgatcctgt cttagggcag aggccaccag    900 
               
               
                   
               
               
                 ggagtgggga tcctgaggga aggggcaggg atttctcctt cttcttggtc ctggctccca    960 
               
               
                   
               
               
                 agggcttctg tcttcatctc tgcatgagct ctccttccca gagaccaact cttttttatt   1020 
               
               
                   
               
               
                 ttattttatt ttatttttta atttatgtct ggagcctggc tactctgcat ttgggattgg   1080 
               
               
                   
               
               
                 ggatgctggg tgggtgtgtg gtccatgttc agcgttctag caacacgtgt gtgtgtgtgt   1140 
               
               
                   
               
               
                 gtgtaaaggc tatgcagcca aaataccatc tggccagacg ggcccacccc aaaaaaaaaa   1200 
               
               
                   
               
               
                 aaaggaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                              1235 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 70 
               
               
                 &lt;211&gt; LENGTH: 118 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 70 
               
               
                   
               
               
                 Met Ser Lys Pro Leu Ser Tyr Met Thr Trp Leu Phe Leu Leu Pro Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Pro Leu Val Phe Val Ser Leu Phe Ser Pro Leu Ala Leu Leu Ala Leu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Trp Leu Cys Glu Gly Val Val Phe Ser Leu Gly Pro Cys Arg Cys 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Val Cys Gly Ser Arg Pro His Arg Pro Gln Arg Ala Gly Gln Arg Pro 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Glu Arg Pro Ser Glu Ala Arg Arg Arg Glu Pro Ser Gly Asp Glu Gln 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Glu Ala Ala Glu His Ala Gly Gly Ala Ala His Gln Glu Tyr Ala Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ala Gln Gly Tyr Gly Ser Ser Val Pro Gly Asn Cys Ala Ala Gln Gln 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Gly Val Arg Gly Ala Ser 
               
               
                         115 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 71 
               
               
                 &lt;211&gt; LENGTH: 835 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 71 
               
               
                   
               
               
                 gggggaaaag ggcggaaaag gacaaggatc caaactggcg aatttgctga tcttcgcgtc     60 
               
               
                   
               
               
                 cctctccgct ttccggccgg cagcgctgcc agggtatatt tccttttttc cgatcctgca    120 
               
               
                   
               
               
                 acagcctctt taaactgttt aaatgagaat gtccttggct cagagagtac tactcacctg    180 
               
               
                   
               
               
                 gcttttcaca ctactcttct tgatcatgtt ggtgttgaaa ctggatgaga aagcaccttg    240 
               
               
                   
               
               
                 gaactggttc ctcatattta ttccagtctg gatatttgat actatccttc ttgtcctgct    300 
               
               
                   
               
               
                 gattgtgaaa atggctgggc ggtgtaagtc tggctttgac cctcgacatg gatcacacaa    360 
               
               
                   
               
               
                 tattaaaaaa aaagcctggt acctcattgc aatgttactt aaattagcct tctgcctcgc    420 
               
               
                   
               
               
                 actctgtgct aaactggaac agtttactac catgaatcta tcctatgtct tcattccttt    480 
               
               
                   
               
               
                 atgggccttg ctggctgggg cttaaacaga actcggatat aatgtctttt gtgagagaga    540 
               
               
                   
               
               
                 ctgacttcta agtacatcat ctcctttcta ttgcggttca acaagttacc attaaagtgt    600 
               
               
                   
               
               
                 tctgaatctg tcaagcttca agaataccag agaactgagg ggaaatacca aaggtagttt    660 
               
               
                   
               
               
                 tatactactt ccataaaaca agattggtga atcacggact tctagtcaac ctacagctta    720 
               
               
                   
               
               
                 attattcagc atttgagtta ttgagatccc tattatctct agggaaataa agtttgtttt    780 
               
               
                   
               
               
                 ggacctcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa         835 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 72 
               
               
                 &lt;211&gt; LENGTH: 120 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 72 
               
               
                   
               
               
                 Met Arg Met Ser Leu Ala Gln Arg Val Leu Leu Thr Trp Leu Phe Thr 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Leu Leu Phe Leu Ile Met Leu Val Leu Lys Leu Asp Glu Lys Ala Pro 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Trp Asn Trp Phe Leu Ile Phe Ile Pro Val Trp Ile Phe Asp Thr Ile 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Leu Val Leu Leu Ile Val Lys Met Ala Gly Arg Cys Lys Ser Gly 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Phe Asp Pro Arg His Gly Ser His Asn Ile Lys Lys Lys Ala Trp Tyr 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Ile Ala Met Leu Leu Lys Leu Ala Phe Cys Leu Ala Leu Cys Ala 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Lys Leu Glu Gln Phe Thr Thr Met Asn Leu Ser Tyr Val Phe Ile Pro 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Leu Trp Ala Leu Leu Ala Gly Ala 
               
               
                         115                 120 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 73 
               
               
                 &lt;211&gt; LENGTH: 1287 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 73 
               
               
                   
               
               
                 ccgaggcggg aggatgaagt tgattgacta tggtctctcc ggctaccagg aagagtctgc     60 
               
               
                   
               
               
                 cgaaggtgaa ggccatggac ttcatcacct ccacagccat cctgcccctg ctgttcggct    120 
               
               
                   
               
               
                 gcctgggcgt cttcggcctc ttccggctgc tgcagtgggt gcgcgggaag gcctacctgc    180 
               
               
                   
               
               
                 ggaatgctgt ggtggtgatc acaggcgcca cctcagggct gggcaaagaa tgtgcaaaag    240 
               
               
                   
               
               
                 tcttctatgc tgcgggtgct aaactggtgc tctgtggccg gaatggtggg gccctagaag    300 
               
               
                   
               
               
                 agctcatcag agaactcacc gcttctcatg ccaccaaggt gcagacacac aagccttact    360 
               
               
                   
               
               
                 tggtgacctt cgacctcaca gactctgggg ccatagttgc agcagcagct gagatcctgc    420 
               
               
                   
               
               
                 agtgctttgg ctatgtcgac atacttgtca acaatgctgg gatcagctac cgtggtacca    480 
               
               
                   
               
               
                 tcatggacac cacagtggat gtggacaaga gggtcatgga gacaaactac tttggcccag    540 
               
               
                   
               
               
                 ttgctctaac gaaagcactc ctgccctcca tgatcaagag gaggcaaggc cacattgtcg    600 
               
               
                   
               
               
                 ccatcagcag catccagggc aagatgagca ttccttttcg atcagcatat gcagcctcca    660 
               
               
                   
               
               
                 agcacgcaac ccaggctttc tttgactgtc tgcgtgccga gatggaacag tatgaaattg    720 
               
               
                   
               
               
                 aggtgaccgt catcagcccc ggctacatcc acaccaacct ctctgtaaat gccatcaccg    780 
               
               
                   
               
               
                 cggatggatc taggtatgga gttatggaca ccaccacagc ccagggccga agccctgtgg    840 
               
               
                   
               
               
                 aggtggccca ggatgttctt gctgctgtgg ggaagaagaa gaaagatgtg atcctggctg    900 
               
               
                   
               
               
                 acttactgcc ttccttggct gtttatcttc gaactctggc tcctgggctc ttcttcagcc    960 
               
               
                   
               
               
                 tcatggcctc cagggccaga aaagagcgga aatccaagaa ctcctagtac tctgaccagc   1020 
               
               
                   
               
               
                 cagggccagg gcagagaagc agcactctta ggcttgctta ctctacaagg gacagttgca   1080 
               
               
                   
               
               
                 tttgttgaga ctttaatgga gatttttctc acaagtggga aagactgaag aaacacatct   1140 
               
               
                   
               
               
                 cgtgcagatc tgctggcaga ggacaatcaa aaacgacaac aagcttcttc ccagggtgag   1200 
               
               
                   
               
               
                 gggaaacact taaggaataa atatggagct ggggtttaac actaaaacta gaaataaaca   1260 
               
               
                   
               
               
                 tctcaaacag taaaaaaaaa aaaaaaa                                       1287 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 74 
               
               
                 &lt;211&gt; LENGTH: 325 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 74 
               
               
                   
               
               
                 Met Val Ser Pro Ala Thr Arg Lys Ser Leu Pro Lys Val Lys Ala Met 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Asp Phe Ile Thr Ser Thr Ala Ile Leu Pro Leu Leu Phe Gly Cys Leu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gly Val Phe Gly Leu Phe Arg Leu Leu Gln Trp Val Arg Gly Lys Ala 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Tyr Leu Arg Asn Ala Val Val Val Ile Thr Gly Ala Thr Ser Gly Leu 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gly Lys Glu Cys Ala Lys Val Phe Tyr Ala Ala Gly Ala Lys Leu Val 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Cys Gly Arg Asn Gly Gly Ala Leu Glu Glu Leu Ile Arg Glu Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Thr Ala Ser His Ala Thr Lys Val Gln Thr His Lys Pro Tyr Leu Val 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Thr Phe Asp Leu Thr Asp Ser Gly Ala Ile Val Ala Ala Ala Ala Glu 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Ile Leu Gln Cys Phe Gly Tyr Val Asp Ile Leu Val Asn Asn Ala Gly 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Ile Ser Tyr Arg Gly Thr Ile Met Asp Thr Thr Val Asp Val Asp Lys 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Arg Val Met Glu Thr Asn Tyr Phe Gly Pro Val Ala Leu Thr Lys Ala 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Leu Leu Pro Ser Met Ile Lys Arg Arg Gln Gly His Ile Val Ala Ile 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Ser Ser Ile Gln Gly Lys Met Ser Ile Pro Phe Arg Ser Ala Tyr Ala 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Ala Ser Lys His Ala Thr Gln Ala Phe Phe Asp Cys Leu Arg Ala Glu 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Met Glu Gln Tyr Glu Ile Glu Val Thr Val Ile Ser Pro Gly Tyr Ile 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 His Thr Asn Leu Ser Val Asn Ala Ile Thr Ala Asp Gly Ser Arg Tyr 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Gly Val Met Asp Thr Thr Thr Ala Gln Gly Arg Ser Pro Val Glu Val 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Ala Gln Asp Val Leu Ala Ala Val Gly Lys Lys Lys Lys Asp Val Ile 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Leu Ala Asp Leu Leu Pro Ser Leu Ala Val Tyr Leu Arg Thr Leu Ala 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Pro Gly Leu Phe Phe Ser Leu Met Ala Ser Arg Ala Arg Lys Glu Arg 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Lys Ser Lys Asn Ser 
               
               
                                 325 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 75 
               
               
                 &lt;211&gt; LENGTH: 1396 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 75 
               
               
                   
               
               
                 cggaggaggt ggcggcgctg gagctcctcc cggggaccag cgacccgggg agcgagcacg     60 
               
               
                   
               
               
                 tcgctccgca ccgctcttcc tccagccgct gagccgtccc ttctcgccat gtcccagagc    120 
               
               
                   
               
               
                 aggcaccgcg ccgaggcccc gccgctggag cgcgaggaca gtgggacctt cagtttgggg    180 
               
               
                   
               
               
                 aagatgataa cagctaagcc agggaaaaca ccgattcagg tattacacga atacggcatg    240 
               
               
                   
               
               
                 aagaccaaga acatcccagt ttatgaatgt gaaagatctg atgtgcaaat acacgtgccc    300 
               
               
                   
               
               
                 actttcacct tcagagtaac cgttggtgac ataacctgca caggtgaagg tacaagtaag    360 
               
               
                   
               
               
                 aagctggcga aacatagagc tgcagaggct gccataaaca ttttgaaagc caatgcaagt    420 
               
               
                   
               
               
                 atttgctttg cagttcctga ccccttaatg cctgaccctt ccaagcaacc aaagaaccag    480 
               
               
                   
               
               
                 cttaatccta ttggttcatt acaggaattg gctattcatc atggctggag acttcctgaa    540 
               
               
                   
               
               
                 tatacccttt cccaggaggg aggacctgct cataagagag aatatactac aatttgcagg    600 
               
               
                   
               
               
                 ctagagtcat ttatggaaac tggaaagggg gcatcaaaaa agcaagccaa aaggaatgct    660 
               
               
                   
               
               
                 gctgagaaat ttcttgccaa atttagtaat atttctccag agaaccacat ttctttaaca    720 
               
               
                   
               
               
                 aatgtagtag gacattcttt aggatgtact tggcattcct tgaggaattc tcctggtgaa    780 
               
               
                   
               
               
                 aagatcaact tactgaaaag aagcctcctt agtattccaa atacagatta catccagctg    840 
               
               
                   
               
               
                 cttagtgaaa ttgccaagga acaaggtttt aatataacat atttggatat agatgaactg    900 
               
               
                   
               
               
                 agcgccaatg gacaatatca atgtcttgct gaactgtcca ccagccccat cacagtctgt    960 
               
               
                   
               
               
                 catggctccg gtatctcctg tggcaatgca caaagtgatg cagctcacaa tgctttgcag   1020 
               
               
                   
               
               
                 tatttaaaga taatagcaga aagaaagtaa atctggagca acttaaaaaa tctttcagta   1080 
               
               
                   
               
               
                 gcacataaaa agttcccctc tggccccttc ccaagtaaaa cttttaccgt agtgtttatg   1140 
               
               
                   
               
               
                 tcttgtttct aaatctcttc atagattcca tcaacactcc agatttaatt atctcctcat   1200 
               
               
                   
               
               
                 agttgttatt aagctctttt taatggcttc aactttgtat cagtatactg tatttataaa   1260 
               
               
                   
               
               
                 ctttgtacca caagagagag tgtagcaccc attttacagt gccatgcaca tcagagaaag   1320 
               
               
                   
               
               
                 aaactgcatg tttgttgttg atgatgaaat aaaaatgcta gcgacagtca aaaaaaaaaa   1380 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaa                                                   1396 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 76 
               
               
                 &lt;211&gt; LENGTH: 313 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 76 
               
               
                   
               
               
                 Met Ser Gln Ser Arg His Arg Ala Glu Ala Pro Pro Leu Glu Arg Glu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Asp Ser Gly Thr Phe Ser Leu Gly Lys Met Ile Thr Ala Lys Pro Gly 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Lys Thr Pro Ile Gln Val Leu His Glu Tyr Gly Met Lys Thr Lys Asn 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ile Pro Val Tyr Glu Cys Glu Arg Ser Asp Val Gln Ile His Val Pro 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Thr Phe Thr Phe Arg Val Thr Val Gly Asp Ile Thr Cys Thr Gly Glu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly Thr Ser Lys Lys Leu Ala Lys His Arg Ala Ala Glu Ala Ala Ile 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Asn Ile Leu Lys Ala Asn Ala Ser Ile Cys Phe Ala Val Pro Asp Pro 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Leu Met Pro Asp Pro Ser Lys Gln Pro Lys Asn Gln Leu Asn Pro Ile 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Gly Ser Leu Gln Glu Leu Ala Ile His His Gly Trp Arg Leu Pro Glu 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Tyr Thr Leu Ser Gln Glu Gly Gly Pro Ala His Lys Arg Glu Tyr Thr 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Thr Ile Cys Arg Leu Glu Ser Phe Met Glu Thr Gly Lys Gly Ala Ser 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Lys Lys Gln Ala Lys Arg Asn Ala Ala Glu Lys Phe Leu Ala Lys Phe 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Ser Asn Ile Ser Pro Glu Asn His Ile Ser Leu Thr Asn Val Val Gly 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 His Ser Leu Gly Cys Thr Trp His Ser Leu Arg Asn Ser Pro Gly Glu 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Lys Ile Asn Leu Leu Lys Arg Ser Leu Leu Ser Ile Pro Asn Thr Asp 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Tyr Ile Gln Leu Leu Ser Glu Ile Ala Lys Glu Gln Gly Phe Asn Ile 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Thr Tyr Leu Asp Ile Asp Glu Leu Ser Ala Asn Gly Gln Tyr Gln Cys 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Leu Ala Glu Leu Ser Thr Ser Pro Ile Thr Val Cys His Gly Ser Gly 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Ile Ser Cys Gly Asn Ala Gln Ser Asp Ala Ala His Asn Ala Leu Gln 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Tyr Leu Lys Ile Ile Ala Glu Arg Lys 
               
               
                 305                 310 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 77 
               
               
                 &lt;211&gt; LENGTH: 1238 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 77 
               
               
                   
               
               
                 tccgcggatt cccagcttga gaaacacctc tttgccccgt catgccaaag aggaaagtga     60 
               
               
                   
               
               
                 ccttccaagg cgtgggagat gaggaggatg aggatgaaat cattgtcccc aagaagaagc    120 
               
               
                   
               
               
                 tggtggaccc tgtggctggg tcagggggtc ctgggagccg ctttaaaggc aaacactctt    180 
               
               
                   
               
               
                 tggatagcga tgaggaggag gatgatgatg atggggggtc cagcaaatat gacatcttgg    240 
               
               
                   
               
               
                 cctcagagga tgtagaaggt caggaggcag ccacactccc cagcgagggg ggtgttcgga    300 
               
               
                   
               
               
                 tcacaccctt taacctgcag gaggagatgg aggaaggcca ctttgatgcc gatggcaact    360 
               
               
                   
               
               
                 acttcctgaa ccgggatgct cagatccgag acagctggct ggacaacatt gactgggtga    420 
               
               
                   
               
               
                 agatccggga gcggccacct ggccagcgcc aggcctcaga ctcggaggag gaggacagct    480 
               
               
                   
               
               
                 tgggccagac ctcaatgagt gcccaagccc tcttggaggg acttttggag ctcctattgc    540 
               
               
                   
               
               
                 ctagagagac agtggctggg gcactgaggc gtctgggggc ccgaggagga ggcaaaggga    600 
               
               
                   
               
               
                 gaaaggggcc tgggcaaccc agttcccctc agcgcctgga ccggctctcc gggttggccg    660 
               
               
                   
               
               
                 accagatggt ggcccggggc aaccttggtg tgtaccagga aacaagggaa cggttggcta    720 
               
               
                   
               
               
                 tgcgtctgaa gggtttgggg tgtcagaccc taggacccca caatcccaca cccccaccct    780 
               
               
                   
               
               
                 ccctggacat gttcgctgag gagttggcgg aggaggaact ggagacccca acccctaccc    840 
               
               
                   
               
               
                 agagaggaga agcagagtcg cggggagatg gtctggtgga tgtgatgtgg gaatataagt    900 
               
               
                   
               
               
                 gggagaacac gggggatgcc gagctgtatg ggcccttcac cagcgcccag atgcagaccg    960 
               
               
                   
               
               
                 gggtgagtga aggctacttc ccggacggtg tttattgccg gaagctgggc ccccctgggg   1020 
               
               
                   
               
               
                 gtcagttcta caactccaaa cgcattgacg ttgacctcta caccggagcc ggctgggggc   1080 
               
               
                   
               
               
                 ccagtttggt gggcccttct ttcctggact ttgtggagga ggcgccaagt gtctcaggca   1140 
               
               
                   
               
               
                 gcgcaggaaa ttggaggcca tttttcagtc aatttccctt tcccaataaa agcctttagt   1200 
               
               
                   
               
               
                 tgtgtaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                           1238 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 78 
               
               
                 &lt;211&gt; LENGTH: 385 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 78 
               
               
                   
               
               
                 Met Pro Lys Arg Lys Val Thr Phe Gln Gly Val Gly Asp Glu Glu Asp 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Glu Asp Glu Ile Ile Val Pro Lys Lys Lys Leu Val Asp Pro Val Ala 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gly Ser Gly Gly Pro Gly Ser Arg Phe Lys Gly Lys His Ser Leu Asp 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ser Asp Glu Glu Glu Asp Asp Asp Asp Gly Gly Ser Ser Lys Tyr Asp 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ile Leu Ala Ser Glu Asp Val Glu Gly Gln Glu Ala Ala Thr Leu Pro 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ser Glu Gly Gly Val Arg Ile Thr Pro Phe Asn Leu Gln Glu Glu Met 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Glu Glu Gly His Phe Asp Ala Asp Gly Asn Tyr Phe Leu Asn Arg Asp 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ala Gln Ile Arg Asp Ser Trp Leu Asp Asn Ile Asp Trp Val Lys Ile 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Arg Glu Arg Pro Pro Gly Gln Arg Gln Ala Ser Asp Ser Glu Glu Glu 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Asp Ser Leu Gly Gln Thr Ser Met Ser Ala Gln Ala Leu Leu Glu Gly 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Leu Leu Glu Leu Leu Leu Pro Arg Glu Thr Val Ala Gly Ala Leu Arg 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Arg Leu Gly Ala Arg Gly Gly Gly Lys Gly Arg Lys Gly Pro Gly Gln 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Pro Ser Ser Pro Gln Arg Leu Asp Arg Leu Ser Gly Leu Ala Asp Gln 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Met Val Ala Arg Gly Asn Leu Gly Val Tyr Gln Glu Thr Arg Glu Arg 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Leu Ala Met Arg Leu Lys Gly Leu Gly Cys Gln Thr Leu Gly Pro His 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Asn Pro Thr Pro Pro Pro Ser Leu Asp Met Phe Ala Glu Glu Leu Ala 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Glu Glu Glu Leu Glu Thr Pro Thr Pro Thr Gln Arg Gly Glu Ala Glu 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Ser Arg Gly Asp Gly Leu Val Asp Val Met Trp Glu Tyr Lys Trp Glu 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Asn Thr Gly Asp Ala Glu Leu Tyr Gly Pro Phe Thr Ser Ala Gln Met 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Gln Thr Gly Val Ser Glu Gly Tyr Phe Pro Asp Gly Val Tyr Cys Arg 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Lys Leu Gly Pro Pro Gly Gly Gln Phe Tyr Asn Ser Lys Arg Ile Asp 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Val Asp Leu Tyr Thr Gly Ala Gly Trp Gly Pro Ser Leu Val Gly Pro 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Ser Phe Leu Asp Phe Val Glu Glu Ala Pro Ser Val Ser Gly Ser Ala 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 Gly Asn Trp Arg Pro Phe Phe Ser Gln Phe Pro Phe Pro Asn Lys Ser 
               
               
                     370                 375                 380 
               
               
                   
               
               
                 Leu 
               
               
                 385 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 79 
               
               
                 &lt;211&gt; LENGTH: 1558 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1488..1489) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 79 
               
               
                   
               
               
                 cttctgtgcc gggggtcttc ctgctgtcat gaaggacgta ccgggcttcc tacagcagag     60 
               
               
                   
               
               
                 ccagaactcc gggcccgggc agcccgctgt gtggcaccgt ctggaggagc tctacacgaa    120 
               
               
                   
               
               
                 gaagttgtgg catcagctga cacttcaggt gcttgatttt gtgcaggatc cgtgctttgc    180 
               
               
                   
               
               
                 ccaaggagat ggtctcatta agctttatga aaactttatc agtgaatttg aacacagggt    240 
               
               
                   
               
               
                 gaaccctttg tccctcgtgg aaatcattct tcatgtagtt agacagatga ctgatcctaa    300 
               
               
                   
               
               
                 tgtggctctt acttttctgg aaaagactcg tgagaaggtg aaaagtagtg atgaggcagt    360 
               
               
                   
               
               
                 gatcctgtgt aaaacagcaa ttggagctct aaaattaaac atcggggacc tacaggttac    420 
               
               
                   
               
               
                 aaaggaaaca attgaagatg ttgaagaaat gctcaacaac cttcctggtg tgacatcggt    480 
               
               
                   
               
               
                 tcacagtcgt ttctatgatc tctccagtaa atactatcaa acaatcggaa accacgcgtc    540 
               
               
                   
               
               
                 ctactacaaa gatgctctgc ggtttttggg ctgtgttgac atcaaggatc taccagtgtc    600 
               
               
                   
               
               
                 tgagcagcag gagagagcct tcacgctggg gctagcagga cttctcggcg agggagtttt    660 
               
               
                   
               
               
                 taactttgga gaactcctca tgcaccctgt gctggagtcc ctgaggaata ctgaccggca    720 
               
               
                   
               
               
                 gtggctgatt gacaccctct atgccttcaa cagtggcaac gtagagcggt tccagactct    780 
               
               
                   
               
               
                 gaagactgcc tggggccagc agcctgattt agcagctaat gaagcccagc ttctgaggaa    840 
               
               
                   
               
               
                 aattcagttg ttgtgcctca tggagatgac tttcacacga cctgccaatc acagacaact    900 
               
               
                   
               
               
                 cacttttgaa gaaattgcca aaagtgctaa aatcacagtg aatgaggtgg agcttctggt    960 
               
               
                   
               
               
                 gatgaaggcc ctttcggtgg ggctggtgaa aggcagtata gacgaggtgg acaaacgagt   1020 
               
               
                   
               
               
                 ccacatgacc tgggtgcagc cccgagtgtt ggatttgcaa cagatcaagg gaatgaagga   1080 
               
               
                   
               
               
                 ccgcctggag ttctggtgca cggatgtgaa gagcatggag atgctggtgg agcaccaggc   1140 
               
               
                   
               
               
                 ccatgacatc ctcacctagg gccccctggt tccccgtcgt gtctcctttg actcacctga   1200 
               
               
                   
               
               
                 gagaggcgtt tgcagccaat gaagctggct gctcagacgg tcgacattga atttgggtgg   1260 
               
               
                   
               
               
                 gggttgggat cctgtctgaa gtacagactg ttcttgctct aaaaacagga ctgtccctga   1320 
               
               
                   
               
               
                 tgggagccag gccacaggga ggaggcttct ttgtgggtct ctcctgcaga gggtgggggt   1380 
               
               
                   
               
               
                 ctcagggtct taggtgatac gggagagaaa gaacgtgcca ggcaggaggc cccctgaagt   1440 
               
               
                   
               
               
                 ctgtgtactc cgaggtggat ctccatcccc atccacctgt acggacannt tttccgttgc   1500 
               
               
                   
               
               
                 ggtttgagaa tgttcctata ataaacccct ctgctttgtt cttaaaaaaa aaaaaaaa     1558 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 80 
               
               
                 &lt;211&gt; LENGTH: 376 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 80 
               
               
                   
               
               
                 Met Lys Asp Val Pro Gly Phe Leu Gln Gln Ser Gln Asn Ser Gly Pro 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Gly Gln Pro Ala Val Trp His Arg Leu Glu Glu Leu Tyr Thr Lys Lys 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Trp His Gln Leu Thr Leu Gln Val Leu Asp Phe Val Gln Asp Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Cys Phe Ala Gln Gly Asp Gly Leu Ile Lys Leu Tyr Glu Asn Phe Ile 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ser Glu Phe Glu His Arg Val Asn Pro Leu Ser Leu Val Glu Ile Ile 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu His Val Val Arg Gln Met Thr Asp Pro Asn Val Ala Leu Thr Phe 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Leu Glu Lys Thr Arg Glu Lys Val Lys Ser Ser Asp Glu Ala Val Ile 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Leu Cys Lys Thr Ala Ile Gly Ala Leu Lys Leu Asn Ile Gly Asp Leu 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Gln Val Thr Lys Glu Thr Ile Glu Asp Val Glu Glu Met Leu Asn Asn 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Leu Pro Gly Val Thr Ser Val His Ser Arg Phe Tyr Asp Leu Ser Ser 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Lys Tyr Tyr Gln Thr Ile Gly Asn His Ala Ser Tyr Tyr Lys Asp Ala 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Leu Arg Phe Leu Gly Cys Val Asp Ile Lys Asp Leu Pro Val Ser Glu 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Gln Gln Glu Arg Ala Phe Thr Leu Gly Leu Ala Gly Leu Leu Gly Glu 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Gly Val Phe Asn Phe Gly Glu Leu Leu Met His Pro Val Leu Glu Ser 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Leu Arg Asn Thr Asp Arg Gln Trp Leu Ile Asp Thr Leu Tyr Ala Phe 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Asn Ser Gly Asn Val Glu Arg Phe Gln Thr Leu Lys Thr Ala Trp Gly 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Gln Gln Pro Asp Leu Ala Ala Asn Glu Ala Gln Leu Leu Arg Lys Ile 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Gln Leu Leu Cys Leu Met Glu Met Thr Phe Thr Arg Pro Ala Asn His 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Arg Gln Leu Thr Phe Glu Glu Ile Ala Lys Ser Ala Lys Ile Thr Val 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Asn Glu Val Glu Leu Leu Val Met Lys Ala Leu Ser Val Gly Leu Val 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Lys Gly Ser Ile Asp Glu Val Asp Lys Arg Val His Met Thr Trp Val 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Gln Pro Arg Val Leu Asp Leu Gln Gln Ile Lys Gly Met Lys Asp Arg 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Leu Glu Phe Trp Cys Thr Asp Val Lys Ser Met Glu Met Leu Val Glu 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 His Gln Ala His Asp Ile Leu Thr 
               
               
                     370                 375 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 81 
               
               
                 &lt;211&gt; LENGTH: 1257 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1201) 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1204) 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1206) 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1215) 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1217) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 81 
               
               
                   
               
               
                 ccagctctgg tatcgtaaat gtttgtagcc aatacaacat ccctggttat gatagaagga     60 
               
               
                   
               
               
                 tgcccttgac tggcccagct ctggtatcct aaatgttcgg agccgatata acatccctgg    120 
               
               
                   
               
               
                 ttatgataga aggatgcctt ttcttagacg tgaggatgcg tcccacgggc ttcagcactg    180 
               
               
                   
               
               
                 ggtctgctct gtggaacttc caggccgaag ctggggaggg taatggggca gcatggctgc    240 
               
               
                   
               
               
                 aggagtcgag ctcagtgcct gagccgggag ctcgatgcgg gagctgtggg ctgctcctcc    300 
               
               
                   
               
               
                 tccctgctag gagcaggtgc aagaggcctg cagagtgctg gggctgggca cggacctcac    360 
               
               
                   
               
               
                 agtgccatga agcctcgtgc agctttgaat ttcacttgtg atttcttcat ggaacttcaa    420 
               
               
                   
               
               
                 agccctagca atgtaggcgc gtagtcaatt attatttgag taagtgactg cgtgcaatgg    480 
               
               
                   
               
               
                 cccaggataa gggggttctg gagagggcag tccgtgctcc tattctttct ctgtctactt    540 
               
               
                   
               
               
                 tattatgatt tttgcttttt actatgaaaa attttaagcc ttcagaaaag tagagtgata    600 
               
               
                   
               
               
                 tgccacccat atacctatta tctagattta agaagaagaa tgattttcca tctgttattt    660 
               
               
                   
               
               
                 gctgtgtttg ggaaggattt taaagtacag acgtcatgac attttacctc taaatgcttc    720 
               
               
                   
               
               
                 ggatgcaact ctaaaaaata aggatgtttt catacttaac cacattttta tgaatacgct    780 
               
               
                   
               
               
                 gaacaaagca aatcagttta tttgtccccc aaatattttg atttgttcaa acaagaattc    840 
               
               
                   
               
               
                 agtcagagtc cccatgatgc gtgtggtggt gcttggtggt gccttagttc ctttgacatg    900 
               
               
                   
               
               
                 ggacagcccc tcccagctct tcatttctca tgagttgaaa aggctgggcc gggcccgatg    960 
               
               
                   
               
               
                 ctcacgcctg taatcccagc actttgggag gcgtgaggca ggtggatcac gaggtcagga   1020 
               
               
                   
               
               
                 gatcgagacc atcctggcta acatggtgaa accctgtctg tactaaaaga atacaaaaaa   1080 
               
               
                   
               
               
                 ttagccgggt gtggtggcgc gcgcccgtag tccctgctac ctgggaggct gaggcaggag   1140 
               
               
                   
               
               
                 agtggtgtga acccggcagg cggaaattaa agtgagccga gatcgctctt tgtactcgta   1200 
               
               
                   
               
               
                 ngtngnggtc agatngngga ctctcgtctc aaaaaaaaaa aaaaaaaaaa aaaaaaa      1257 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 82 
               
               
                 &lt;211&gt; LENGTH: 102 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 82 
               
               
                   
               
               
                 Met Phe Gly Ala Asp Ile Thr Ser Leu Val Met Ile Glu Gly Cys Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Phe Leu Asp Val Arg Met Arg Pro Thr Gly Phe Ser Thr Gly Ser Ala 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Trp Asn Phe Gln Ala Glu Ala Gly Glu Gly Asn Gly Ala Ala Trp 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Gln Glu Ser Ser Ser Val Pro Glu Pro Gly Ala Arg Cys Gly Ser 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Cys Gly Leu Leu Leu Leu Pro Ala Arg Ser Arg Cys Lys Arg Pro Ala 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Glu Cys Trp Gly Trp Ala Arg Thr Ser Gln Cys His Glu Ala Ser Cys 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ser Phe Glu Phe His Leu 
               
               
                             100 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 83 
               
               
                 &lt;211&gt; LENGTH: 2520 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 83 
               
               
                   
               
               
                 ccacctgccg ggtaagggcc cctcgggccg tggtcgggca tcgattggcc ccgcctggcg     60 
               
               
                   
               
               
                 cagcccccgc ccctgcagcg gactgcggtg ctcatcagac ctgagcagtt gctccggcgg    120 
               
               
                   
               
               
                 cgctcgggga gggagccagc agcctagggc ctaggcccgg gccaccatgg cgctgcctcc    180 
               
               
                   
               
               
                 aggcccagcc gccctccggc acacactgct gctcctgcca gcccttctga gctcaggttg    240 
               
               
                   
               
               
                 gggggagttg gagccacaaa tagatggtca gacctgggct gagcgggcac ttcgggagaa    300 
               
               
                   
               
               
                 tgaacgccac gccttcacct gccgggtggc aggggggcct ggcaccccca gattggcctg    360 
               
               
                   
               
               
                 gtatctggat ggacagctgc aggaggccag cacctcaaga ctgctgagcg tgggagggga    420 
               
               
                   
               
               
                 ggccttctct ggaggcacca gcaccttcac tgtcactgcc catcgggccc agcatgagct    480 
               
               
                   
               
               
                 caactgctct ctgcaggacc ccagaagtgg ccgatcagcc aacgcctctg tcatccttaa    540 
               
               
                   
               
               
                 tgtgcaattc aagccagaga ttgcccaagt cggcgccaag taccaggaag ctcagggccc    600 
               
               
                   
               
               
                 aggcctcctg gttgtcctgt ttgccctggt gcgtgccaac ccgccggcca atgtcacctg    660 
               
               
                   
               
               
                 gatcgaccag gatgggccag tgactgtcaa cacctctgac ttcctggtgc tggatgcgca    720 
               
               
                   
               
               
                 gaactacccc tggctcacca accacacggt gcagctgcag ctccgcagcc tggcacacaa    780 
               
               
                   
               
               
                 cctctcggtg gtggccacca atgacgtggg tgtcaccagt gcgtcgcttc cagccccagg    840 
               
               
                   
               
               
                 gcttctggct acccgggtgg aagtgccact gctgggcatt gttgtggctg ctgggcttgc    900 
               
               
                   
               
               
                 actgggcacc ctcgtggggt tcagcacctt ggtggcctgc ctggtctgca gaaaagagaa    960 
               
               
                   
               
               
                 gaaaaccaaa ggcccctccc ggcacccatc tctgatatca agtgactcca acaacctaaa   1020 
               
               
                   
               
               
                 actcaacaac gtgcgcctgc cacgggagaa catgtccctc ccgtccaacc ttcagctcaa   1080 
               
               
                   
               
               
                 tgacctcact ccagattcca gagcagtgaa accagcagac cggcagatgg ctcagaacaa   1140 
               
               
                   
               
               
                 cagccggcca gagcttctgg acccggagcc cggcggcctc ctcaccagcc aaggtttcat   1200 
               
               
                   
               
               
                 ccgcctccca gtgctgggct atatctatcg agtgtccagc gtgagcagtg atgagatctg   1260 
               
               
                   
               
               
                 gctctgagcc gagggcgaga caggagtatt ctcttggcct ctggacaccc tcccattcct   1320 
               
               
                   
               
               
                 ccaaggcatc ctctacctag ctaggtcacc aacgtgaaga agttatgcca ctgccacttt   1380 
               
               
                   
               
               
                 tgcttgccct cctggctggg gtgccctcca tgtcatgcac gtgatgcatt tcactgggct   1440 
               
               
                   
               
               
                 gtaacccgca ggggcacagg tatctttggc aaggctacca gttggacgta agcccctcat   1500 
               
               
                   
               
               
                 gctgactcag ggtgggccct gcatgtgatg actgggccct tccagaggga gctctttggc   1560 
               
               
                   
               
               
                 caggggtgtt cagatgtcat ccagcatcca agtgtggcat ggcctgctgt ataccccacc   1620 
               
               
                   
               
               
                 ccagtactcc acagcacctt gtacagtagg catgggggcg tgcctgtgtg ggggacaggg   1680 
               
               
                   
               
               
                 agggccctgc atggattttc ctccttccta tgctatgtag ccttgttccc tcaggtaaaa   1740 
               
               
                   
               
               
                 tttaggaccc tgctagctgt gcagaaccca attgcccttt gcacagaaac caacccctga   1800 
               
               
                   
               
               
                 cccagcggta ccggccaagc acaaacgtcc tttttgctgc acacgtctct gcccttcact   1860 
               
               
                   
               
               
                 tcttctcttc tgtcccacct cctcttggga attctaggtt acacgttgga ccttctctac   1920 
               
               
                   
               
               
                 tacttcactg ggcactagac ttttctattg gcctgtgcca tcgcccagta ttagcacaag   1980 
               
               
                   
               
               
                 ttagggagga agaggcaggc gatgagtcta gtagcaccca ggacggcttg tagctatgca   2040 
               
               
                   
               
               
                 tcattttcct acggcgttag cactttaagc acatccctag ggaggggtga gtgagggccc   2100 
               
               
                   
               
               
                 agagccctct ttgtggcttc cccacgtttg gccttctggg attcactgtg agtgtcctga   2160 
               
               
                   
               
               
                 gctctcgggg ttgatggttt ttctctcagc atgtctcctc caccacggga ccccagccct   2220 
               
               
                   
               
               
                 gaccaaccca tggttgcctc atcagcagga aggtgccctt cctggaggat ggtcgccaca   2280 
               
               
                   
               
               
                 ggcacataat tcaacagtgt ggaagcttta ggggaacatg gagaaagaag gagaccacat   2340 
               
               
                   
               
               
                 accccaaagt gacctaagaa cactttaaaa agcaacatgt aaatgattgg aaattaatat   2400 
               
               
                   
               
               
                 agtacagaat atatttttcc cttgttgaga tcttcttttg taatgttttt catgttactg   2460 
               
               
                   
               
               
                 cctagggcgg tgctgagcac acagcaagtt taataaactt gactgaattc aaaaaaaaaa   2520 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 84 
               
               
                 &lt;211&gt; LENGTH: 366 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 84 
               
               
                   
               
               
                 Met Ala Leu Pro Pro Gly Pro Ala Ala Leu Arg His Thr Leu Leu Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Leu Pro Ala Leu Leu Ser Ser Gly Trp Gly Glu Leu Glu Pro Gln Ile 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Asp Gly Gln Thr Trp Ala Glu Arg Ala Leu Arg Glu Asn Glu Arg His 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ala Phe Thr Cys Arg Val Ala Gly Gly Pro Gly Thr Pro Arg Leu Ala 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Trp Tyr Leu Asp Gly Gln Leu Gln Glu Ala Ser Thr Ser Arg Leu Leu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ser Val Gly Gly Glu Ala Phe Ser Gly Gly Thr Ser Thr Phe Thr Val 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Thr Ala His Arg Ala Gln His Glu Leu Asn Cys Ser Leu Gln Asp Pro 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Arg Ser Gly Arg Ser Ala Asn Ala Ser Val Ile Leu Asn Val Gln Phe 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Lys Pro Glu Ile Ala Gln Val Gly Ala Lys Tyr Gln Glu Ala Gln Gly 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Pro Gly Leu Leu Val Val Leu Phe Ala Leu Val Arg Ala Asn Pro Pro 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Ala Asn Val Thr Trp Ile Asp Gln Asp Gly Pro Val Thr Val Asn Thr 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Ser Asp Phe Leu Val Leu Asp Ala Gln Asn Tyr Pro Trp Leu Thr Asn 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 His Thr Val Gln Leu Gln Leu Arg Ser Leu Ala His Asn Leu Ser Val 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Val Ala Thr Asn Asp Val Gly Val Thr Ser Ala Ser Leu Pro Ala Pro 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Gly Leu Leu Ala Thr Arg Val Glu Val Pro Leu Leu Gly Ile Val Val 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Ala Ala Gly Leu Ala Leu Gly Thr Leu Val Gly Phe Ser Thr Leu Val 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Ala Cys Leu Val Cys Arg Lys Glu Lys Lys Thr Lys Gly Pro Ser Arg 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 His Pro Ser Leu Ile Ser Ser Asp Ser Asn Asn Leu Lys Leu Asn Asn 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Val Arg Leu Pro Arg Glu Asn Met Ser Leu Pro Ser Asn Leu Gln Leu 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Asn Asp Leu Thr Pro Asp Ser Arg Ala Val Lys Pro Ala Asp Arg Gln 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Met Ala Gln Asn Asn Ser Arg Pro Glu Leu Leu Asp Pro Glu Pro Gly 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Gly Leu Leu Thr Ser Gln Gly Phe Ile Arg Leu Pro Val Leu Gly Tyr 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Ile Tyr Arg Val Ser Ser Val Ser Ser Asp Glu Ile Trp Leu 
               
               
                         355                 360                 365 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 85 
               
               
                 &lt;211&gt; LENGTH: 1692 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1317) 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1394) 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1424) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 85 
               
               
                   
               
               
                 ctatgtatca tactgagtgt tctgagctgt tagtttcttt ggtgttcatc tagatggaag     60 
               
               
                   
               
               
                 ctggggcttc cttcctttca gatattggtg ctaacatgaa gctgaccaaa gaattgatgg    120 
               
               
                   
               
               
                 gatctgcaca ctgtaaagcc ggtttcagga tggctgagct gacggtcaag aaagaagaga    180 
               
               
                   
               
               
                 agatatgagc cgcctgcatt ttggggtggt ggcagtgaaa tttagacttg tgatttggta    240 
               
               
                   
               
               
                 tgacaatata tggctttttg tgattgttaa cattaatgaa aacaagaaaa attagttgct    300 
               
               
                   
               
               
                 caaaagttga aaaatggatt cataaacttt ttattagaat aaggcaaaag aacatattaa    360 
               
               
                   
               
               
                 aatagaggta aattagaaat gtcaataaga acccatggac attttttata aggagacttt    420 
               
               
                   
               
               
                 atctgttctg tccctacagt gatttatgct cttggatatt tttgctgtca tcctgacaaa    480 
               
               
                   
               
               
                 ttctagttgg aatatggaac aagcttattt gtagacctag tgcctgtggc ttctaaagca    540 
               
               
                   
               
               
                 attttctgaa aagagaaacc actgcctgtt ggaagaatag ttgattccat acctcaagct    600 
               
               
                   
               
               
                 agggaaaaaa aaaatcagaa ttagtctgtg aattctagat gttgagagaa agcagggttt    660 
               
               
                   
               
               
                 cattagggca tcggagagtc acaagtccat aggatgcaaa aaggaagatg aaataaaatt    720 
               
               
                   
               
               
                 gcctgaaaaa cgcacctgaa tttctggcat tgtttactga aaaggctgtg tattgatgaa    780 
               
               
                   
               
               
                 ccccaattat gtgaggtcta catttaagag tttataatca acagtttgaa aatgcagggt    840 
               
               
                   
               
               
                 gttgtttctt tctataagga gacaaaacag tcagaaggga gtgtcacagg acattatcac    900 
               
               
                   
               
               
                 aaaatcaaag ttcttcatga aatgtgttca tttgctagaa ataatgcagc ctattggaga    960 
               
               
                   
               
               
                 gaatcagggc ttctagtgat gctagggatg accttaagca ttgtttgtaa atcacacttt   1020 
               
               
                   
               
               
                 ttcctagtct ttcagcagca gctgcacaga gtaggcctgc ttcttcccat gaaagccaca   1080 
               
               
                   
               
               
                 ctgagtttat caactagtag tgtgtggcac tattgcaagt tatgttgtgt tgttatggcc   1140 
               
               
                   
               
               
                 atttatccaa cagtgctttc ctctgtgtgg ggctctgcag cctcgttcta tgttattttt   1200 
               
               
                   
               
               
                 attaccacgt gtctgtgcgc ctcaggtggc aaagcagaat cagcttctct accctcagca   1260 
               
               
                   
               
               
                 gggctcacta tgactcacta taagggaaga aaatcttaca gatgtcagaa aatgttnggt   1320 
               
               
                   
               
               
                 aagtggacag tgataaacac aaaacagcaa gtggtcagta tcaaagagaa aaacagtatg   1380 
               
               
                   
               
               
                 ttggtgaggg agangtgtca aagctggtta aaaaggtgac gggngaaatg taaggggaca   1440 
               
               
                   
               
               
                 atactccaca aaaatttaga ttgtaactga gcttcttctc ctaaagagat ttaaaaataa   1500 
               
               
                   
               
               
                 agtataggaa atacatgaag aaacaaagta aaatgccaag gtgtaagttt gaccatgaat   1560 
               
               
                   
               
               
                 gtctagggaa aaacatactt gcactaaaac aaccaaatat gcaaaaatca agtggaaaaa   1620 
               
               
                   
               
               
                 caggtcaaaa taatgccagt tgatgtctgt aagaactaaa tgtataataa aatgagcaaa   1680 
               
               
                   
               
               
                 aaaaaaaaaa aa                                                       1692 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 86 
               
               
                 &lt;211&gt; LENGTH: 195 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: UNSURE 
               
               
                 &lt;222&gt; LOCATION: (162) 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: UNSURE 
               
               
                 &lt;222&gt; LOCATION: (188) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 86 
               
               
                   
               
               
                 Met Gln Gly Val Val Ser Phe Tyr Lys Glu Thr Lys Gln Ser Glu Gly 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ser Val Thr Gly His Tyr His Lys Ile Lys Val Leu His Glu Met Cys 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ser Phe Ala Arg Asn Asn Ala Ala Tyr Trp Arg Glu Ser Gly Leu Leu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Val Met Leu Gly Met Thr Leu Ser Ile Val Cys Lys Ser His Phe Phe 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Val Phe Gln Gln Gln Leu His Arg Val Gly Leu Leu Leu Pro Met 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Lys Ala Thr Leu Ser Leu Ser Thr Ser Ser Val Trp His Tyr Cys Lys 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Leu Cys Cys Val Val Met Ala Ile Tyr Pro Thr Val Leu Ser Ser Val 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Trp Gly Ser Ala Ala Ser Phe Tyr Val Ile Phe Ile Thr Thr Cys Leu 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Cys Ala Ser Gly Gly Lys Ala Glu Ser Ala Ser Leu Pro Ser Ala Gly 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Leu Thr Met Thr His Tyr Lys Gly Arg Lys Ser Tyr Arg Cys Gln Lys 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Met Xaa Gly Lys Trp Thr Val Ile Asn Thr Lys Gln Gln Val Val Ser 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Ile Lys Glu Lys Asn Ser Met Leu Val Arg Glu Xaa Cys Gln Ser Trp 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Leu Lys Arg 
               
               
                         195 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 87 
               
               
                 &lt;211&gt; LENGTH: 802 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 87 
               
               
                   
               
               
                 ggcattcttg ccgctggccc agtcactatg tagtggaggg gcagacaccc tcccgcaaat     60 
               
               
                   
               
               
                 tctggaaggt tcttagtctc gactagggca gtagccccag gactcctagt cgccggcttc    120 
               
               
                   
               
               
                 aggtcactgc cggctgaacg gagctgccgt cgccatgttt ggctgcttgg tggcggggag    180 
               
               
                   
               
               
                 gctggtgcaa acagctgcac agcaagtggc agaggataaa tttgtttttg acttacctga    240 
               
               
                   
               
               
                 ttatgaaagt atcaaccatg ttgtggtttt tatgctggga acaatcccat ttcctgaggg    300 
               
               
                   
               
               
                 aatgggagga tctgtctact tttcttatcc tgattcaaat ggaatgccag tatggcaact    360 
               
               
                   
               
               
                 cctaggattt gtcacgaatg ggaagccaag tgccatcttc aaaatttcag gtcttaaatc    420 
               
               
                   
               
               
                 tggagaagga agccaacatc cttttggagc catgaatatt gtccgaactc catctgttgc    480 
               
               
                   
               
               
                 tcagattgga atttcagtgg aattattaga cagtatggct cagcagactc ctgtaggtaa    540 
               
               
                   
               
               
                 tgctgctgta tcctcagttg actcattcac tcagttcaca caaaaggtgt tggacaattt    600 
               
               
                   
               
               
                 ctacaatttt gcttcatcat ttgctgtctc tcaggccccg atgacaccca gcccctctga    660 
               
               
                   
               
               
                 aatgttcatt ccggccaatg tggttctgaa atggtatgaa aactttcaag ggcgactggc    720 
               
               
                   
               
               
                 accgaaccct ctcttttggg aaacataatt tgaataaaat aatttttttt ggaaaaaaaa    780 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aa                                             802 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 88 
               
               
                 &lt;211&gt; LENGTH: 197 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 88 
               
               
                   
               
               
                 Met Phe Gly Cys Leu Val Ala Gly Arg Leu Val Gln Thr Ala Ala Gln 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Gln Val Ala Glu Asp Lys Phe Val Phe Asp Leu Pro Asp Tyr Glu Ser 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ile Asn His Val Val Val Phe Met Leu Gly Thr Ile Pro Phe Pro Glu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gly Met Gly Gly Ser Val Tyr Phe Ser Tyr Pro Asp Ser Asn Gly Met 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Pro Val Trp Gln Leu Leu Gly Phe Val Thr Asn Gly Lys Pro Ser Ala 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ile Phe Lys Ile Ser Gly Leu Lys Ser Gly Glu Gly Ser Gln His Pro 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Phe Gly Ala Met Asn Ile Val Arg Thr Pro Ser Val Ala Gln Ile Gly 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ile Ser Val Glu Leu Leu Asp Ser Met Ala Gln Gln Thr Pro Val Gly 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Asn Ala Ala Val Ser Ser Val Asp Ser Phe Thr Gln Phe Thr Gln Lys 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Val Leu Asp Asn Phe Tyr Asn Phe Ala Ser Ser Phe Ala Val Ser Gln 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Ala Pro Met Thr Pro Ser Pro Ser Glu Met Phe Ile Pro Ala Asn Val 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Val Leu Lys Trp Tyr Glu Asn Phe Gln Gly Arg Leu Ala Pro Asn Pro 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Leu Phe Trp Glu Thr 
               
               
                         195 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 89 
               
               
                 &lt;211&gt; LENGTH: 732 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 89 
               
               
                   
               
               
                 ctggttttct ccgcgggcgc ctcgggcgga acctggagat aatgggcagc acctggggga     60 
               
               
                   
               
               
                 gccctggctg ggtgcgactc gctctttgcc tgacgggctt agtgctctcg ctctacgcgc    120 
               
               
                   
               
               
                 tgcacgtgaa ggcggcgcgc gcccgggacc gggattaccg cgcgctctgc gacgtgggca    180 
               
               
                   
               
               
                 ccgccatcag ctgttcgcgc gtcttctcct ccaggttgcc tgcggacacg ctgggcctct    240 
               
               
                   
               
               
                 gtcctgatgc tgctgagctc cctggtgtct ctcgctggtt ctgtctacct ggcctggatc    300 
               
               
                   
               
               
                 ctgttcttcg tgctctatga tttctgcatt gtttgtatca ccacctatgc tatcaacgtg    360 
               
               
                   
               
               
                 agcctgatgt ggctcagttt ccggaaggtc caagaacccc agggcaaggc taagaggcac    420 
               
               
                   
               
               
                 tgagccctca acccaagcca ggctgacctc atctgctttg ctttggcatg tgagccttgc    480 
               
               
                   
               
               
                 ctaagggggc atatctgggt ccctagaagg ccctagatgt ggggcttcta gattaccccc    540 
               
               
                   
               
               
                 tcctcctgcc atacccacac atgacaatgg accaaatgtg ccacacgctc gctctttttt    600 
               
               
                   
               
               
                 acacccagtg cctctgactc tgtccccatg ggctggtctc caaagctctt tccattgccc    660 
               
               
                   
               
               
                 agggagggaa ggttctgagc aataaagttt cttagatcaa ccaaaaaaaa aaaaaaaaaa    720 
               
               
                   
               
               
                 aaaaaaaaaa aa                                                        732 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 90 
               
               
                 &lt;211&gt; LENGTH: 92 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 90 
               
               
                   
               
               
                 Met Gly Ser Thr Trp Gly Ser Pro Gly Trp Val Arg Leu Ala Leu Cys 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Leu Thr Gly Leu Val Leu Ser Leu Tyr Ala Leu His Val Lys Ala Ala 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Arg Ala Arg Asp Arg Asp Tyr Arg Ala Leu Cys Asp Val Gly Thr Ala 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ile Ser Cys Ser Arg Val Phe Ser Ser Arg Leu Pro Ala Asp Thr Leu 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gly Leu Cys Pro Asp Ala Ala Glu Leu Pro Gly Val Ser Arg Trp Phe 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Cys Leu Pro Gly Leu Asp Pro Val Leu Arg Ala Leu 
               
               
                                  85                  90 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 91 
               
               
                 &lt;211&gt; LENGTH: 901 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 91 
               
               
                   
               
               
                 ggcgcgatga ggttccggtt ctgtggtgat ctggactgtc ccgactgggt cctggcagaa     60 
               
               
                   
               
               
                 atcagcacgc tggccaagat gtcctctgtg aagttgcggc tgctctgcag ccaggtacta    120 
               
               
                   
               
               
                 aaggagctgc tgggacaggg gattgattat gagaagatcc tgaagctcac ggctgacgcc    180 
               
               
                   
               
               
                 aagtttgagt caggcgatgt gaaggccaca gtggcagtgc tgagtttcat cctctccagt    240 
               
               
                   
               
               
                 gcggccaagc acagtgtcga tggcgaatcc ttgtccagtg aactgcagca gctggggctg    300 
               
               
                   
               
               
                 cccaaagagc acgcggccag cctgtgccgc tgttatgagg agaagcaaag ccccttgcag    360 
               
               
                   
               
               
                 aagcacttgc gggtctgcag cctacgcatg aataggttgg caggtgtggg ctggcgggtg    420 
               
               
                   
               
               
                 gactacaccc tgagctccag cctgctgcaa tccgtggaag agcccatggt gcacctgcgg    480 
               
               
                   
               
               
                 ctggaggtgg cagctgcccc agggacccca gcccagcctg ttgccatgtc cctctcagca    540 
               
               
                   
               
               
                 gacaagttcc aggtcctcct ggcagaactg aagcaggccc agaccctgat gagctccctg    600 
               
               
                   
               
               
                 ggctgaggag aagggtgttc caggcctgtg tggagccgcc ctgcccgtat ggagtcacgc    660 
               
               
                   
               
               
                 cctctgaact gctcttcggg aggcagccct ggttctagga tgctgaggcc ctggcccgga    720 
               
               
                   
               
               
                 ctctggcctc ccagatcccc agctgcctca cttctctctt gagaacttgg ctcagggctc    780 
               
               
                   
               
               
                 ctgaggacct ttcccagcat taccttccct tcccttgaaa ggcaattgtt ggctgttttc    840 
               
               
                   
               
               
                 ataagcagga aaaataaaca gaagtataaa ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa    900 
               
               
                   
               
               
                 a                                                                    901 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 92 
               
               
                 &lt;211&gt; LENGTH: 199 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 92 
               
               
                   
               
               
                 Met Arg Phe Arg Phe Cys Gly Asp Leu Asp Cys Pro Asp Trp Val Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ala Glu Ile Ser Thr Leu Ala Lys Met Ser Ser Val Lys Leu Arg Leu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Cys Ser Gln Val Leu Lys Glu Leu Leu Gly Gln Gly Ile Asp Tyr 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Glu Lys Ile Leu Lys Leu Thr Ala Asp Ala Lys Phe Glu Ser Gly Asp 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Val Lys Ala Thr Val Ala Val Leu Ser Phe Ile Leu Ser Ser Ala Ala 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Lys His Ser Val Asp Gly Glu Ser Leu Ser Ser Glu Leu Gln Gln Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Gly Leu Pro Lys Glu His Ala Ala Ser Leu Cys Arg Cys Tyr Glu Glu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Lys Gln Ser Pro Leu Gln Lys His Leu Arg Val Cys Ser Leu Arg Met 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Asn Arg Leu Ala Gly Val Gly Trp Arg Val Asp Tyr Thr Leu Ser Ser 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Ser Leu Leu Gln Ser Val Glu Glu Pro Met Val His Leu Arg Leu Glu 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Val Ala Ala Ala Pro Gly Thr Pro Ala Gln Pro Val Ala Met Ser Leu 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Ser Ala Asp Lys Phe Gln Val Leu Leu Ala Glu Leu Lys Gln Ala Gln 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Thr Leu Met Ser Ser Leu Gly 
               
               
                         195 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 93 
               
               
                 &lt;211&gt; LENGTH: 1579 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 93 
               
               
                   
               
               
                 gattaaaata ttattttaaa gaaaccactg tttcccccta aaatgtcata agagcactga     60 
               
               
                   
               
               
                 agaacttgaa atattttttt cagagtttct cacacacttt aaaagtctaa cttttttgtg    120 
               
               
                   
               
               
                 tgtaagcatt tagcttgcca gcatatttct ttttggctcc ttaaattgcg gttgtgtttg    180 
               
               
                   
               
               
                 cagtattgtc acttttgctc tcactgttat gttgaataat aattagcata taattgtcta    240 
               
               
                   
               
               
                 cagaagcaag agcaatctgg aaggaacaaa aatgttttct gtgattaaca gtgaagacct    300 
               
               
                   
               
               
                 tgtaaatgca gatgtgtgat aaagcattta gtcagtcccc caaacagtca tgccaactgt    360 
               
               
                   
               
               
                 gaaggaatgt cccacaaaac atttccattc cctgaggaaa aacattttct ttcctacatg    420 
               
               
                   
               
               
                 tatctctggt atttagaatt gtcactaata accttttcaa gtgattttgg ctattctcta    480 
               
               
                   
               
               
                 atgaagatat ggtcatttgt ttttcttcct gcaatgtggt gtgcagagat gctgcatatc    540 
               
               
                   
               
               
                 ctttttatgg gattgcgtgt gaatttgaac catgagacat tcctaataat ttgttgtgag    600 
               
               
                   
               
               
                 atataccaag catggatgat aagtgtgttt ttagtggtgt gttgtttttt taaagaggtg    660 
               
               
                   
               
               
                 attcaagtac cgttgctaag ctgtcaacat accaagctgt tgaaaaaatt gaccatttct    720 
               
               
                   
               
               
                 ttcagaagta attctcagcc tgtggaataa tagcaggtga agacttcata gaaggcgaca    780 
               
               
                   
               
               
                 gattgatagg gaggctattg aagcagtttt tctgaagcct gcattttgag ttagtttata    840 
               
               
                   
               
               
                 gtgctaatag attctatata actgtgagag tttggtagta aaccagtagg gattgttttc    900 
               
               
                   
               
               
                 tctcctaaaa atttgcacac tacttcattg tctacaactt tttacatatt ggaaaataga    960 
               
               
                   
               
               
                 aattgcaaat acatacatgt atggaaacat attcagattg ggaaaaacat ggacattagt   1020 
               
               
                   
               
               
                 tttttaaaag ttacgtggag caagatttct atattttgtt ttttaaagga cgcagtcatt   1080 
               
               
                   
               
               
                 ctttctacta aatccatttc aggctagttc tctgaaaatt ttgccattta tctacagaaa   1140 
               
               
                   
               
               
                 tttgattata aatatgttcc ttttcaaaga aactttattc tagaacaaaa tagtctatat   1200 
               
               
                   
               
               
                 ggtacttgat ctacatataa gtggaaaaat tagcagtatt tgaaagctca gtttatgtca   1260 
               
               
                   
               
               
                 ttgtcttaac ttcagataca aataactgaa cagaaagtta taacctttaa tatctcatgt   1320 
               
               
                   
               
               
                 tctgtttttt attcagtatt ttcctatatg ttaattcaat tatatacttc tgaatggcac   1380 
               
               
                   
               
               
                 cttacttttt ggaaacaaat cttctgttat ttacaaaata tataattttt aaaaaacatt   1440 
               
               
                   
               
               
                 taaaaaaatc caaagctgct ctcgataata gtcaacattt gcatatatat ggaatttctt   1500 
               
               
                   
               
               
                 actttttttc tcccaaactc tatttaataa acttatttta atgtttgtat aaaaaaaaaa   1560 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaa                                                1579 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 94 
               
               
                 &lt;211&gt; LENGTH: 127 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 94 
               
               
                   
               
               
                 Met Ser His Lys Thr Phe Pro Phe Pro Glu Glu Lys His Phe Leu Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Tyr Met Tyr Leu Trp Tyr Leu Glu Leu Ser Leu Ile Thr Phe Ser Ser 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Asp Phe Gly Tyr Ser Leu Met Lys Ile Trp Ser Phe Val Phe Leu Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ala Met Trp Cys Ala Glu Met Leu His Ile Leu Phe Met Gly Leu Arg 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Val Asn Leu Asn His Glu Thr Phe Leu Ile Ile Cys Cys Glu Ile Tyr 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gln Ala Trp Met Ile Ser Val Phe Leu Val Val Cys Cys Phe Phe Lys 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Glu Val Ile Gln Val Pro Leu Leu Ser Cys Gln His Thr Lys Leu Leu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Lys Lys Leu Thr Ile Ser Phe Arg Ser Asn Ser Gln Pro Val Glu 
               
               
                         115                 120                 125 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 95 
               
               
                 &lt;211&gt; LENGTH: 1891 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 95 
               
               
                   
               
               
                 agctggaggg agtcatggtg tcactggggt acaggagggt gaatgaaggg catgcaggcc     60 
               
               
                   
               
               
                 ctcagcccgg gctgtgccag ccctcccagc cccaggccca tctgagggac caagacgctg    120 
               
               
                   
               
               
                 ttacgcaggc ccttctttcc agctatcagc actttcagca tcggctcttc agcagatcca    180 
               
               
                   
               
               
                 aaccccctca gcaacttgca gaggacctgt cccctctcaa aagtcccctg gcctagggtg    240 
               
               
                   
               
               
                 gggaccccca aacctacggc aaagccagca acagtagcag cctgctccca tttgctgggg    300 
               
               
                   
               
               
                 aggagatcat cttgttcccc tggcccccca ctctccctcc atgtccatcc aaaaaccata    360 
               
               
                   
               
               
                 aaatcactgg gttccacatc agcctccatg aggccaagcc ttgtacctgc aaggctcttg    420 
               
               
                   
               
               
                 gcctaaccat tcctctgtcc tcttctctgg cctgcctggg gagcccgtga aggccgcacg    480 
               
               
                   
               
               
                 ggtgcctcca gcctgagaca tcaggggaga gcctgcagct gagttcagca gaaaggagga    540 
               
               
                   
               
               
                 atcctggccc tcaggaagaa gatagtcaca tgtttttctt ccttgtcccc acagccccca    600 
               
               
                   
               
               
                 gaacaacatt ctccctgctg gcagcccttc catgtctcca aacctgggtc agagtgaaag    660 
               
               
                   
               
               
                 gacctttggg ggtgggtggg agcaaagggc ccacctgctg gttggtgaaa gcagtggtgc    720 
               
               
                   
               
               
                 cggagtgcta ggtaccgcac gagagggtgc gggggcttgg gaagcagacc agggttggac    780 
               
               
                   
               
               
                 aaaaccccat gagggcgggg agctggaaga aaagtctctt ggggacctct ggggcaagga    840 
               
               
                   
               
               
                 gctgagaagt cctgcagcac caggtgaaac ttgcttacag tggatgccac ttttaggcct    900 
               
               
                   
               
               
                 ctggaccgca gatgccttct tccttctgga cacctggctt ctgggcctcc aggtaaagag    960 
               
               
                   
               
               
                 agagagccag ccaagcctgt tcccctcagt cctcctttgc tcctgctgct tcttccaaca   1020 
               
               
                   
               
               
                 gccactgtta ggaggtagta gaccccagcc tcaaggctct gaccttcttc atgtgggcac   1080 
               
               
                   
               
               
                 agaggtcctg acactctggc agggcctgag ctggggcagg cctccctcag ggccaggggc   1140 
               
               
                   
               
               
                 gatggcaccc cggggacagg cagacctcct tcctgccgtc agcaccccct tccttatcac   1200 
               
               
                   
               
               
                 tgtctggtct ccgagcttcg gctgcagcct gaggtgtgtc ctgggctcct cagagcctga   1260 
               
               
                   
               
               
                 agcaagcttt tggaagcctg cagtcctccc agctccagtg cagaagcctc tctctccagc   1320 
               
               
                   
               
               
                 ctttccccag gcaggagttg gggttggggg cctctgtccc tcatcgctta ccttggaaag   1380 
               
               
                   
               
               
                 gtgggaagct ggcaatctgc accttggggc ctgggctccc cctctctgtg ccagcggctt   1440 
               
               
                   
               
               
                 cccagcacct gggaggggct gcagccccag ctggactcca gcctgtccct cttagcactc   1500 
               
               
                   
               
               
                 tagctgccca ctccagggca gggactcgaa accccctccg tcctgagcag ccacctccag   1560 
               
               
                   
               
               
                 ggccctgttt gggaccactc tctcagtccc caggtcctca gggccccaga gcgggagggt   1620 
               
               
                   
               
               
                 ctcctacctg gaagtccccc tgagctccag ggcccagccc tacctgccag tgctggtgtc   1680 
               
               
                   
               
               
                 agggcactca accccgagtg tggggccacg ccccttgcca tgcccacggc ctcctcctgt   1740 
               
               
                   
               
               
                 agcccctgcc tgcccccccg atgctgcacg ggcccgccct ggtggggctc ggcgagtaat   1800 
               
               
                   
               
               
                 gtgttttgtc cccagttaac caccattctg cggcctggtt ctgcaaggaa ccagggctgc   1860 
               
               
                   
               
               
                 cccaccacca cgaaacacaa aaaaaaaaaa a                                  1891 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 96 
               
               
                 &lt;211&gt; LENGTH: 287 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 96 
               
               
                   
               
               
                 Met Ser Pro Asn Leu Gly Gln Ser Glu Arg Thr Phe Gly Gly Gly Trp 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Glu Gln Arg Ala His Leu Leu Val Gly Glu Ser Ser Gly Ala Gly Val 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Gly Thr Ala Arg Glu Gly Ala Gly Ala Trp Glu Ala Asp Gln Gly 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Trp Thr Lys Pro His Glu Gly Gly Glu Leu Glu Glu Lys Ser Leu Gly 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Asp Leu Trp Gly Lys Glu Leu Arg Ser Pro Ala Ala Pro Gly Glu Thr 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Cys Leu Gln Trp Met Pro Leu Leu Gly Leu Trp Thr Ala Asp Ala Phe 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Phe Leu Leu Asp Thr Trp Leu Leu Gly Leu Gln Val Lys Arg Glu Ser 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Gln Pro Ser Leu Phe Pro Ser Val Leu Leu Cys Ser Cys Cys Phe Phe 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Gln Gln Pro Leu Leu Gly Gly Ser Arg Pro Gln Pro Gln Gly Ser Asp 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Leu Leu His Val Gly Thr Glu Val Leu Thr Leu Trp Gln Gly Leu Ser 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Trp Gly Arg Pro Pro Ser Gly Pro Gly Ala Met Ala Pro Arg Gly Gln 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Ala Asp Leu Leu Pro Ala Val Ser Thr Pro Phe Leu Ile Thr Val Trp 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Ser Pro Ser Phe Gly Cys Ser Leu Arg Cys Val Leu Gly Ser Ser Glu 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Pro Glu Ala Ser Phe Trp Lys Pro Ala Val Leu Pro Ala Pro Val Gln 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Lys Pro Leu Ser Pro Ala Phe Pro Gln Ala Gly Val Gly Val Gly Gly 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Leu Cys Pro Ser Ser Leu Thr Leu Glu Arg Trp Glu Ala Gly Asn Leu 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 His Leu Gly Ala Trp Ala Pro Pro Leu Cys Ala Ser Gly Phe Pro Ala 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Pro Gly Arg Gly Cys Ser Pro Ser Trp Thr Pro Ala Cys Pro Ser 
               
               
                         275                 280                 285 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 97 
               
               
                 &lt;211&gt; LENGTH: 2192 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (891) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 97 
               
               
                   
               
               
                 ctgttaacag tactttaatt gagccgtctg tgttctagtt ctgtccagag cccccgccgt     60 
               
               
                   
               
               
                 tttcccctcc agcacaggat tcatttcagg atcatcactt gcgttatatg cccaaggggt    120 
               
               
                   
               
               
                 ccctctcttg gtgtgtgggc agagccagag ctgggaacaa tgggggtggt gtgtgggttc    180 
               
               
                   
               
               
                 tgggctcagg cttcctggat ttggcattgg cctcctgatg tcatgtatcg gctggaagac    240 
               
               
                   
               
               
                 tcaggacaac cttctgcctt tctgagcctc cgtttcctca aacctgaagt gaggatgaag    300 
               
               
                   
               
               
                 gcagcgtgca tggcttaggg gcgttgggtg ctcagcatcg tgcgtgagat gctgagtgtt    360 
               
               
                   
               
               
                 caccactcag tattagccat ggatgtcttt ttggaaattc cccacagccc tctccacaca    420 
               
               
                   
               
               
                 gagtcaaatg tcaaaaacct gctgccaact ggcacctggt tctcacagct gctctctggg    480 
               
               
                   
               
               
                 gctctggggc ctgtcagagc cacctgtcca agattcagga ttcagcacat cacctctgcc    540 
               
               
                   
               
               
                 ccacccctac cggcagcatt cctttcctac ctgtccagcc tcttctctgt ccccagccac    600 
               
               
                   
               
               
                 attccccact cctgccccca aactcttggc ctagaaggcc ctggcctgct ccccaggcct    660 
               
               
                   
               
               
                 cctctgctaa gccttgccta cctgtcccca ctgtgccccc cactgcctgc gcatctctgg    720 
               
               
                   
               
               
                 ccagcacagg cgtgggagga actatggctc ttcttcctta ggaagagtct ctgacaagta    780 
               
               
                   
               
               
                 ggactttgtt ttcttcccag catgcactgc agtgcaggtg tcttaaccct tggcgcacac    840 
               
               
                   
               
               
                 acaggatgaa ggcagagagc caactattga gggtgggaat tgggaagcct nctgcctgga    900 
               
               
                   
               
               
                 tcatcttaga aactggaggc cccttttcac tcgggtctcc cctgtgccgt gcacgccacc    960 
               
               
                   
               
               
                 tctttcaggg cccactcacc ctgggtggaa ttggatggcc actttgccag aacttcttcg   1020 
               
               
                   
               
               
                 tcttttgttg acctgttctg gccattaaga ccaccttctc ttttctgggg ggtttccgcc   1080 
               
               
                   
               
               
                 tgtcctttgc tacggtactt ggagacaggt gagctcactt tgttctttgc tttaagtctg   1140 
               
               
                   
               
               
                 ttacctcttg agccaaggtg aggcacctcc aggggcagcc aggcccctgc ttctggcccc   1200 
               
               
                   
               
               
                 gcacaccctc tacactttga cctttccggc tgtttacctg cctggagtgt gcctcactcc   1260 
               
               
                   
               
               
                 cctcccctca gttgatcttt tactgtgctc tctctatgta gcgccctctt gctcccttct   1320 
               
               
                   
               
               
                 aaaactccat tctggaaaaa ctcagccatt gtcttttttt gtttgttttt ttcctgtttt   1380 
               
               
                   
               
               
                 aatctttagt gagcctgtgt atccataggg cttgtgagga aaaacagcgg ccctttgccc   1440 
               
               
                   
               
               
                 caaccagcat ccaccctagg gacaatcact ttcaactcag tggactcttg gaatttgcgc   1500 
               
               
                   
               
               
                 ccgtagctct aaaaactgtg ctggctgctt ctcagtcttt cagctcaggg cagaatccat   1560 
               
               
                   
               
               
                 tgccttccac caggagagct gaacatcagt gctctcgtgg ctccatgagt cctcttagcc   1620 
               
               
                   
               
               
                 cctttctctc ctctcatctt ccctggtagt tccccataat tgtgatgaga atacctgtgt   1680 
               
               
                   
               
               
                 aggtcagtca tcggagtggt gtgaagggat gtgtggccca gtgacatctc agctgccatt   1740 
               
               
                   
               
               
                 tctgcttgct ttgccgtgag tgttctttgc tttgtttctt ggctctaacc caattccagg   1800 
               
               
                   
               
               
                 cttcctcctg attgtttcac tcttctctct ggccacttat ttatttattt ttcgagatgg   1860 
               
               
                   
               
               
                 agtctccctc tgtcacccag gctggagtgc attggtgtgt tctctgctca ctgcaacctc   1920 
               
               
                   
               
               
                 tgcctcctgg gttcaagcaa ttctcctacc tcagcctcct gagtagctgg gactacaggc   1980 
               
               
                   
               
               
                 gtgtgccact atgcctggct aatttattta tttttatttt tttatttttt tgagatggag   2040 
               
               
                   
               
               
                 tctcactctg tcacccaggc tggagtgcag tggcgcgttc tcggctcact gcaactccgc   2100 
               
               
                   
               
               
                 ctcccaggtt cacgccattc tcctacctca gcctcccagg tagctgggac tacaggtgct   2160 
               
               
                   
               
               
                 cgccaccacc acgaaacaaa aaaaaaaaaa aa                                 2192 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 98 
               
               
                 &lt;211&gt; LENGTH: 141 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 98 
               
               
                   
               
               
                 Met Leu Ser Val His His Ser Val Leu Ala Met Asp Val Phe Leu Glu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ile Pro His Ser Pro Leu His Thr Glu Ser Asn Val Lys Asn Leu Leu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Pro Thr Gly Thr Trp Phe Ser Gln Leu Leu Ser Gly Ala Leu Gly Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Val Arg Ala Thr Cys Pro Arg Phe Arg Ile Gln His Ile Thr Ser Ala 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Pro Pro Leu Pro Ala Ala Phe Leu Ser Tyr Leu Ser Ser Leu Phe Ser 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Val Pro Ser His Ile Pro His Ser Cys Pro Gln Thr Leu Gly Leu Glu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Gly Pro Gly Leu Leu Pro Arg Pro Pro Leu Leu Ser Leu Ala Tyr Leu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ser Pro Leu Cys Pro Pro Leu Pro Ala His Leu Trp Pro Ala Gln Ala 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Trp Glu Glu Leu Trp Leu Phe Phe Leu Arg Lys Ser Leu 
               
               
                     130                 135                 140 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 99 
               
               
                 &lt;211&gt; LENGTH: 1774 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 99 
               
               
                   
               
               
                 cagaggagga ataatgagga actggtagtg tcagcctcct gtaaggaacc agagcaggag     60 
               
               
                   
               
               
                 ccagtgccag cacagttcca gaaagtaaag cccccaaaga ctaatcataa acgaggaagg    120 
               
               
                   
               
               
                 aaataggcag tcagtgtaaa agtgctccta ggaaagcaga tgtgatgctg ttgtcacggg    180 
               
               
                   
               
               
                 gacctgtgct gggaggactg agtgaagatt ctttcagctg tttgtgtaag gctgtgactt    240 
               
               
                   
               
               
                 tctcagctcc ttcctcctgt gtaaatttca ctgtcttccc ttcttacatt ttgattcccc    300 
               
               
                   
               
               
                 cctccccttt tagtaggttt tcctgctatt cctcgtcaag tcctcttgtt tttttatctt    360 
               
               
                   
               
               
                 gcccaaagag ctccctctca aggccaacta taggctccgc ttgccctgta caaaactaag    420 
               
               
                   
               
               
                 aaacctcttt ggttgtcctt tccttcctgg ggtatagaat gttcttggaa gctccattga    480 
               
               
                   
               
               
                 tttagtagct gctccatcat ctagcttgtg aaaccattcc aaactaattt tttaaaacca    540 
               
               
                   
               
               
                 taactgattt gtcattttgt atttgtgata taacaagtct agaagttaga actgttgtca    600 
               
               
                   
               
               
                 ttcacataat aagattactc tgtctccttg ggaaaaaaac tttatggagg ctgtttgtcc    660 
               
               
                   
               
               
                 tctcaatatg gttttaagat tgaaagtaag aaaacggatt taggatgaaa actctagaac    720 
               
               
                   
               
               
                 taccctatgc tgtttatact gggaaatgct ttgtaccaag tagcagtgac tagacccaca    780 
               
               
                   
               
               
                 gacatgaaaa gcaaccttag gagtaaagtg acccaaacat taaaatgaca ggaaagagaa    840 
               
               
                   
               
               
                 agtagaagca gcaataaata ctgccccaac ttccttggag cccgaggcct catccatagc    900 
               
               
                   
               
               
                 tatgatcact tgccctctga agcttatttt tgcttctttg gttttaagaa ttgagaaata    960 
               
               
                   
               
               
                 tcacattgcc cctgatgttt tgaacagtct ccaagtgctc ctggtagtgc cactaaggga   1020 
               
               
                   
               
               
                 aaaccaaggt gcgcattcct tctccctgga ctttacctta cttgttagtc tacgccccac   1080 
               
               
                   
               
               
                 tgtttccacc catcccctta gccaacctct gtctttttga attttctgag aatattgtcc   1140 
               
               
                   
               
               
                 tatcctcttt tatatatgga gttctctcct ctttatatcc tgagactttg acaccagatg   1200 
               
               
                   
               
               
                 tagatattta tctggagctg gaaagaaaaa ttctttttct gtacctcatg cctatctggt   1260 
               
               
                   
               
               
                 aatgtttaat gggttatttc tctttgaggg tggctttctc tggaacattg gttagagcag   1320 
               
               
                   
               
               
                 ctttgttgtc gtgtttctgg attctcttcc ccattttgcg taaatattgg tcttatatat   1380 
               
               
                   
               
               
                 tcttgcctat tttgtggcat atgccacata aaaaatgaac ctgatataga caagtactac   1440 
               
               
                   
               
               
                 cttttcaaat tctgaaaggc tattaccact ttaactcttt gtgctcctcc aaatagcttt   1500 
               
               
                   
               
               
                 aaaatgtggg cttttgtgaa gaccactttc aaacaaggga gcactgaaac ctgaattgga   1560 
               
               
                   
               
               
                 tactgccaga ataggtagtt ttgaaacaag ttaaggacat ggtatatgca ctctgcattt   1620 
               
               
                   
               
               
                 tcattggcag tgtgccctta aagccctttc agtagatgag ggttgtcagg gaggagaaat   1680 
               
               
                   
               
               
                 gaagaagcta tgttaatttc tggtgagtaa gacctgggga atgtttggca atgacaaaag   1740 
               
               
                   
               
               
                 aaataaatga ctctcaggaa aaaaaaaaaa aaaa                               1774 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 100 
               
               
                 &lt;211&gt; LENGTH: 84 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 100 
               
               
                   
               
               
                 Met Leu Leu Ser Arg Gly Pro Val Leu Gly Gly Leu Ser Glu Asp Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Phe Ser Cys Leu Cys Lys Ala Val Thr Phe Ser Ala Pro Ser Ser Cys 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Val Asn Phe Thr Val Phe Pro Ser Tyr Ile Leu Ile Pro Pro Ser Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Phe Ser Arg Phe Ser Cys Tyr Ser Ser Ser Ser Pro Leu Val Phe Leu 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ser Cys Pro Lys Ser Ser Leu Ser Arg Pro Thr Ile Gly Ser Ala Cys 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Pro Val Gln Asn 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 101 
               
               
                 &lt;211&gt; LENGTH: 1324 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 101 
               
               
                   
               
               
                 ggtgtcgagc cctctggcag agggttaacc tgggtcaaat gcacggattc tcacctcgta     60 
               
               
                   
               
               
                 cagttacgct ctcccgcggc acgtccgcga ggacttgaag tcctgagcgc tcaagtttgt    120 
               
               
                   
               
               
                 ccgtaggtcg agagaaggcc atggaggtgc cgccaccggc accgcggagc tttctctgta    180 
               
               
                   
               
               
                 gagcattgtg cctatttccc cgagtctttg ctgccgaagc tgtgactgcc gattcggaag    240 
               
               
                   
               
               
                 tccttgagga gcgtcagaag cggcttccct acgtcccaga gccctattac ccggaatctg    300 
               
               
                   
               
               
                 gatgggaccg cctccgggag ctgtttggca aagatgaaca gcagagaatt tcaaaggacc    360 
               
               
                   
               
               
                 ttgctaatat ctgtaagacg gcagctacag caggcatcat tggctgggtg tatgggggaa    420 
               
               
                   
               
               
                 taccagcttt tattcatgct aaacaacaat acattgagca gagccaggca gaaatttatc    480 
               
               
                   
               
               
                 ataaccggtt tgatgctgtg caatctgcac atcgtgctgc cacacgaggc ttcattcgtt    540 
               
               
                   
               
               
                 atggctggcg ctggggttgg agaactgcag tgtttgtgac tatattcaac acagtgaaca    600 
               
               
                   
               
               
                 ctagtctgaa tgtataccga aataaagatg ccttaagcca ttttgtaatt gcaggagctg    660 
               
               
                   
               
               
                 tcacgggaag tctttttagg ataaacgtag gcctgcgtgg cctggtggct ggtggcataa    720 
               
               
                   
               
               
                 ttggagcctt gctgggcact cctgtaggag gcctgctgat ggcatttcag aagtactctg    780 
               
               
                   
               
               
                 gtgagactgt tcaggaaaga aaacagaagg atcgaaaggc actccatgag ctaaaactgg    840 
               
               
                   
               
               
                 aagagtggaa aggcagacta caagttactg agcacctccc tgagaaaatt gaaagtagtt    900 
               
               
                   
               
               
                 tacaggaaga tgaacctgag aatgatgcta agaaaattga agcactgcta aaccttccta    960 
               
               
                   
               
               
                 gaaacccttc agtaatagat aaacaagaca aggactgaaa gtgctctgaa cttgaaactc   1020 
               
               
                   
               
               
                 actggagagc tgaagggagc tgccatgtcc gatgaatgcc aacagacagg ccactctttg   1080 
               
               
                   
               
               
                 gtcagcctgc tgacaaattt aagtgctggt acctgtggtg gcagtggctt gctcttgtct   1140 
               
               
                   
               
               
                 ttttcttttc tttttaacta agaatggggc tgttgtactc tcactttact tatccttcaa   1200 
               
               
                   
               
               
                 tttaaataca tacttatgtt tgtattaatc tatcaatata tgcatacatg aatatatcca   1260 
               
               
                   
               
               
                 cccacctaga ttttaagcag taaataaaac atttcgcaaa agaaaaaaaa aaaaaaaaaa   1320 
               
               
                   
               
               
                 aaaa                                                                1324 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 102 
               
               
                 &lt;211&gt; LENGTH: 285 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 102 
               
               
                   
               
               
                 Met Glu Val Pro Pro Pro Ala Pro Arg Ser Phe Leu Cys Arg Ala Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Cys Leu Phe Pro Arg Val Phe Ala Ala Glu Ala Val Thr Ala Asp Ser 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Glu Val Leu Glu Glu Arg Gln Lys Arg Leu Pro Tyr Val Pro Glu Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Tyr Tyr Pro Glu Ser Gly Trp Asp Arg Leu Arg Glu Leu Phe Gly Lys 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Asp Glu Gln Gln Arg Ile Ser Lys Asp Leu Ala Asn Ile Cys Lys Thr 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ala Ala Thr Ala Gly Ile Ile Gly Trp Val Tyr Gly Gly Ile Pro Ala 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Phe Ile His Ala Lys Gln Gln Tyr Ile Glu Gln Ser Gln Ala Glu Ile 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Tyr His Asn Arg Phe Asp Ala Val Gln Ser Ala His Arg Ala Ala Thr 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Arg Gly Phe Ile Arg Tyr Gly Trp Arg Trp Gly Trp Arg Thr Ala Val 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Phe Val Thr Ile Phe Asn Thr Val Asn Thr Ser Leu Asn Val Tyr Arg 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Asn Lys Asp Ala Leu Ser His Phe Val Ile Ala Gly Ala Val Thr Gly 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Ser Leu Phe Arg Ile Asn Val Gly Leu Arg Gly Leu Val Ala Gly Gly 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Ile Ile Gly Ala Leu Leu Gly Thr Pro Val Gly Gly Leu Leu Met Ala 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Phe Gln Lys Tyr Ser Gly Glu Thr Val Gln Glu Arg Lys Gln Lys Asp 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Arg Lys Ala Leu His Glu Leu Lys Leu Glu Glu Trp Lys Gly Arg Leu 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Gln Val Thr Glu His Leu Pro Glu Lys Ile Glu Ser Ser Leu Gln Glu 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Asp Glu Pro Glu Asn Asp Ala Lys Lys Ile Glu Ala Leu Leu Asn Leu 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Pro Arg Asn Pro Ser Val Ile Asp Lys Gln Asp Lys Asp 
               
               
                         275                 280                 285 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 103 
               
               
                 &lt;211&gt; LENGTH: 977 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 103 
               
               
                   
               
               
                 ggcagaggca tcatggaggg tccccgggga tggctggtgc tctgtgtgct ggccatatcg     60 
               
               
                   
               
               
                 ctggcctcta tggtgaccga ggacttgtgc cgagcaccag acgggaagaa aggggaggca    120 
               
               
                   
               
               
                 ggaagacctg gcagacgggg gcggccaggc ctcaaggggg agcaagggga gccgggggcc    180 
               
               
                   
               
               
                 cctggcatcc ggacaggcat ccaaggcctt aaaggagacc agggggaacc tgggccctct    240 
               
               
                   
               
               
                 ggaaaccccg gcaaggtggg ctacccaggg cccagcggcc ccctcggagc ccgtggcatc    300 
               
               
                   
               
               
                 ccgggaatta aaggcaccaa gggcagccca ggaaacatca aggaccagcc gaggccagcc    360 
               
               
                   
               
               
                 ttcaccgcca ttcggcggaa ccccccaatg gggggcaacg tggtcatctt cgacacggtc    420 
               
               
                   
               
               
                 atcaccaacc aggaagaacc gtaccagaac cactccggcc gattcgtctg cactgtaccc    480 
               
               
                   
               
               
                 ggctactact acttcacctt ccaggtgctg tcccagtggg aaatctgcct gtccatcgtc    540 
               
               
                   
               
               
                 tcctcctcaa ggggccaggt ccgacgctcc ctgggcttct gtgacaccac caacaagggg    600 
               
               
                   
               
               
                 ctcttccagg tggtgtcagg gggcatggtg cttcagctgc agcagggtga ccaggtctgg    660 
               
               
                   
               
               
                 gttgaaaaag accccaaaaa gggtcacatt taccagggct ctgaggccga cagcgtcttc    720 
               
               
                   
               
               
                 agcggcttcc tcatcttccc atctgcctga gccagggaag gaccccctcc cccacccacc    780 
               
               
                   
               
               
                 tctctggctt ccatgtccgc ctgtaaaatg ggggcgctat tgcttcagct gctgaaggga    840 
               
               
                   
               
               
                 gggggctggc tctgagagcc ccaggactgg ctgccccgtg acacatgctc taagaagctc    900 
               
               
                   
               
               
                 gtttcttaga cctcttcctg gaataaacat ctgtgtctgt gtctgccaaa aaaaaaaaaa    960 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaa                                                   977 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 104 
               
               
                 &lt;211&gt; LENGTH: 245 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 104 
               
               
                   
               
               
                 Met Glu Gly Pro Arg Gly Trp Leu Val Leu Cys Val Leu Ala Ile Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Leu Ala Ser Met Val Thr Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Thr Gly Ile Gln 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Pro Gly Ile Lys Gly Thr Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Pro Arg Pro Ala Phe Thr Ala Ile Arg Arg Asn Pro Pro Met Gly Gly 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Ile Phe Pro Ser Ala 
               
               
                                 245 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 105 
               
               
                 &lt;211&gt; LENGTH: 1034 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (618) 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (905..906) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 105 
               
               
                   
               
               
                 ctcaggcctt gagggacact tccttcctcc ccactcgcct cctctccact agactttggt     60 
               
               
                   
               
               
                 tcctagaggg cgtggggccg ggtctgaggt tcttgcctgc cttccctccc attggtcttt    120 
               
               
                   
               
               
                 ggttgctcat ccctctaact gcaccccttc ttggtccttc ctccacagac ttcagataat    180 
               
               
                   
               
               
                 agataagtca ttagcaaacc agaccgaatc tttagggtga agagctcccc aaagccatct    240 
               
               
                   
               
               
                 ggtgaggtca ttttggggac cagggactga ttatttgtca cctggatcac aaagatggga    300 
               
               
                   
               
               
                 ctgtctgctc aggctggtgg tgacaggatc ctgacccgtg gtcctctccc gctccctctg    360 
               
               
                   
               
               
                 ctccaccagg acacatgtat aggacactgt gctgtgtgca gtggagaaat ctccctgggc    420 
               
               
                   
               
               
                 caggggaaag ttcagacagt gcctctagat tgtgttttgc ctcctccaat gttgagttga    480 
               
               
                   
               
               
                 catctggacc ccagagccca gcagggcttt ctgtcagaca tgctagggtg gtagaaatgg    540 
               
               
                   
               
               
                 gccctccagg tccccttgca gtgcactggg cagagacctc cggaaagccg gcagcgggag    600 
               
               
                   
               
               
                 cgctttctgg gccgcttnct cccgcacagt gttcccaacc cagtccatcc ggaaaacagt    660 
               
               
                   
               
               
                 ctgtacagca aatgctgtgt gagatcttag gcttttcact ttttttgttt tgttttgttt    720 
               
               
                   
               
               
                 ttgaaagata gaaaaaaata caattaacaa gcctcttttg taaatgggtt tcctttctat    780 
               
               
                   
               
               
                 gtataaaatc gtggtggtcc cttgttttta catgttcatg ctgtgtaatt ttgagatgtt    840 
               
               
                   
               
               
                 actgagatat gttctgaaca taatgtgcat ttttttctgt acagatgaaa taggcgaatt    900 
               
               
                   
               
               
                 taatnnagtg attgatggtt ttttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    960 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1020 
               
               
                   
               
               
                 aaaaaaaaaa aaaa                                                     1034 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 106 
               
               
                 &lt;211&gt; LENGTH: 118 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: UNSURE 
               
               
                 &lt;222&gt; LOCATION: (82) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 106 
               
               
                   
               
               
                 Met Tyr Arg Thr Leu Cys Cys Val Gln Trp Arg Asn Leu Pro Gly Pro 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Gly Glu Ser Ser Asp Ser Ala Ser Arg Leu Cys Phe Ala Ser Ser Asn 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Val Glu Leu Thr Ser Gly Pro Gln Ser Pro Ala Gly Leu Ser Val Arg 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 His Ala Arg Val Val Glu Met Gly Pro Pro Gly Pro Leu Ala Val His 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Trp Ala Glu Thr Ser Gly Lys Pro Ala Ala Gly Ala Leu Ser Gly Pro 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Xaa Pro Ala Gln Cys Ser Gln Pro Ser Pro Ser Gly Lys Gln Ser 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Val Gln Gln Met Leu Cys Glu Ile Leu Gly Phe Ser Leu Phe Leu Phe 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Cys Phe Val Phe Glu Arg 
               
               
                         115 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 107 
               
               
                 &lt;211&gt; LENGTH: 882 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 107 
               
               
                   
               
               
                 cccatctgcc cctcacctcg tcatccaggg acccaaaccc tgcaccttcc atgtgggccc     60 
               
               
                   
               
               
                 acagatcctt ggcaggtacc tgaggtgcac cattgagtgt cggatttggg gttagcatcc    120 
               
               
                   
               
               
                 agaaagaaga atgcgcatga cgctctgtga aggctggaac tcaggtcttc agggagagaa    180 
               
               
                   
               
               
                 aggaagactg gattgcacct tgatgcctcc tgaggaggcg gaccccctct tgaggtgggc    240 
               
               
                   
               
               
                 gtgggcccgg cccagcctta tccaagtcgc tctgtccacc tcccccttcc tggcccccac    300 
               
               
                   
               
               
                 cccactcctg tgcctcccag gagccctccc tgtgctccac ctgcctccgc agaaggaagc    360 
               
               
                   
               
               
                 ctctttctct gtttccctgg gtgagggggc tggcaggtgg ctaaccccat ttagcatctc    420 
               
               
                   
               
               
                 caggccctgc catggtgtct catcttgctg ttatctctag atctttccct cctcccattt    480 
               
               
                   
               
               
                 cctttagtag ttgaattttg caaagcttgt agcagtagct cagttgcctg cagcatcctt    540 
               
               
                   
               
               
                 gtgtgtagat aaattagtcg acagaaactc agcactgggg acaggattgc aaagtcgggg    600 
               
               
                   
               
               
                 acatagatgc agacagttgt tgagatttgg ggatagccgg gcttgtgagc ggtgcccatt    660 
               
               
                   
               
               
                 tccagatgaa gcctttcagc ccttctgagt ccccggccct tggtgcgatg tctgtgagtt    720 
               
               
                   
               
               
                 tgacctgccc agcgtgtggg ctggctcaat gctgaataaa gtgggtttgt gtcaaaaaaa    780 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    840 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                       882 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 108 
               
               
                 &lt;211&gt; LENGTH: 109 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 108 
               
               
                   
               
               
                 Met Arg Met Thr Leu Cys Glu Gly Trp Asn Ser Gly Leu Gln Gly Glu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Lys Gly Arg Leu Asp Cys Thr Leu Met Pro Pro Glu Glu Ala Asp Pro 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Leu Arg Trp Ala Trp Ala Arg Pro Ser Leu Ile Gln Val Ala Leu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ser Thr Ser Pro Phe Leu Ala Pro Thr Pro Leu Leu Cys Leu Pro Gly 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ala Leu Pro Val Leu His Leu Pro Pro Gln Lys Glu Ala Ser Phe Ser 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Val Ser Leu Gly Glu Gly Ala Gly Arg Trp Leu Thr Pro Phe Ser Ile 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ser Arg Pro Cys His Gly Val Ser Ser Cys Cys Tyr Leu 
               
               
                             100                 105 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 109 
               
               
                 &lt;211&gt; LENGTH: 1547 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 109 
               
               
                   
               
               
                 cctaaaagtc ctgcccttta gttcagtgga ttctggattc tgaggatact cttggtcctt     60 
               
               
                   
               
               
                 tccagagatg aaggcaggca ggggtcaggg cccacagaag ggaatcccta tattcttggg    120 
               
               
                   
               
               
                 gttgtctgag ccagggctca tgcctgtctg gtgctttcaa ccaaacctct ctcatgggct    180 
               
               
                   
               
               
                 ctgtaaaagg aacaatcagg ccattctgaa tcccccagat cttgtaccta ccttttagaa    240 
               
               
                   
               
               
                 ttgtcttgag agtgtgtgtg ctgattctcc taaagtactt cgtgtggttc ctgacctata    300 
               
               
                   
               
               
                 ataagtgctt cataaatctt agtcattatt gttaaaatcc caaagagtgg ttttgctcga    360 
               
               
                   
               
               
                 gtctgaatcc aaaaaggaag ctccaggtaa gaggagaaac tagagaacag gacacagaaa    420 
               
               
                   
               
               
                 ccatcctgtg ttttttctat cctgtgaaac catcaccatg acactggcct tccctctcag    480 
               
               
                   
               
               
                 tgtggcctca tcctccatgt ccctccctgt agtcccctta actgtgaagt gtccagcctc    540 
               
               
                   
               
               
                 tccagcactt actcccaggc ccagctccac ttcaggcagg cctgctgggg ctcagaatag    600 
               
               
                   
               
               
                 cccagctgct gtctcagcag atggccaggc taattttagc catgtggtac tcacccaggg    660 
               
               
                   
               
               
                 accaggctgg gctttttaga tttgaataag ccagtgtgca actttggttt agagccaata    720 
               
               
                   
               
               
                 acaaagtttg gagctgttgt gatctctgtg tctgcctagc actttataag attccagaaa    780 
               
               
                   
               
               
                 tataatttta aaggattttg tttctgtgaa ccaacaagaa cccaagctat ggagccagca    840 
               
               
                   
               
               
                 ggcagtcaag ccagcagggt attgatggag ggtggtgaga agcagatggt ggcaccagct    900 
               
               
                   
               
               
                 cctgcctctt ctccctgatg acaaagcggg tggcagggcc tcagtatccc gggtgcactg    960 
               
               
                   
               
               
                 tgctctcact gctctcctgg ccaaagtgaa agaaggccgc cgccaactca gcctcctgga   1020 
               
               
                   
               
               
                 tcatcctctg aaccagtcgt gggtggcagg ctgcatctta atgatgtgga acaaatgtgg   1080 
               
               
                   
               
               
                 tccgggagaa gtcagcccga tgccagcaag aacctactct ggcactttca tgtgcagtaa   1140 
               
               
                   
               
               
                 atagagacaa cataatgtga agtaggcaga tgtggaaaaa ggctcagaga ggtaagaggt   1200 
               
               
                   
               
               
                 cccaagagag gctgagattg agccaggttg agaacgtgtc ttttaaattg tgatgtttct   1260 
               
               
                   
               
               
                 gccttgttgt tcttcatatg tgaagactgc ctttcatccc agttcttcca gagagttcag   1320 
               
               
                   
               
               
                 ggacaacaca cagtgactcg gaaagccaca ttccagcctg ccttcacctt tccatgatta   1380 
               
               
                   
               
               
                 atttctagtt gcagaagcaa gttgcccaga gaagacagta gaatgaggag accggactgg   1440 
               
               
                   
               
               
                 tcatgcttcc taaactgggt ccatggactc ttaaaagttg gtttgggtgg tctttgggga   1500 
               
               
                   
               
               
                 atctgtttgt ccgttgcgct gtttccgctt aaaaaaaaaa aaaaaaa                 1547 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 110 
               
               
                 &lt;211&gt; LENGTH: 73 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 110 
               
               
                   
               
               
                 Met Thr Leu Ala Phe Pro Leu Ser Val Ala Ser Ser Ser Met Ser Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Pro Val Val Pro Leu Thr Val Lys Cys Pro Ala Ser Pro Ala Leu Thr 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Pro Arg Pro Ser Ser Thr Ser Gly Arg Pro Ala Gly Ala Gln Asn Ser 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Pro Ala Ala Val Ser Ala Asp Gly Gln Ala Asn Phe Ser His Val Val 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Thr Gln Gly Pro Gly Trp Ala Phe 
               
               
                  65                  70 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 111 
               
               
                 &lt;211&gt; LENGTH: 650 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 111 
               
               
                   
               
               
                 cagaagtagt ctgtctatcc cttttatgaa taaaaaagat attactgaag agaaatacag     60 
               
               
                   
               
               
                 tatttgtgtc atataatact taagctgaaa aagctaagtc tgaataaatc agtcattggc    120 
               
               
                   
               
               
                 atttacctta catatggcaa tgaatagtga ctttatagtt agaaatgtat gggtgaaaca    180 
               
               
                   
               
               
                 gtatcagaat gataatgtag aaacatatat aagccccaga ctgcccccta cagcaaaatg    240 
               
               
                   
               
               
                 cgattattaa taactattct gcttgaaata tttggtgaga ttctttcacc catcaagtgc    300 
               
               
                   
               
               
                 ttgtttgtta atattttaat cgggtcggtg tttctttggt tttgtaaatt gtgcacgttt    360 
               
               
                   
               
               
                 acaaagcact ggctgttctc aggcagtttt caagtttaaa tattcttgcc tttagggtca    420 
               
               
                   
               
               
                 ttatttgttc ctggttcccc cactctgcca ttactttttc atactttttc cacaaagatt    480 
               
               
                   
               
               
                 tcagccatac tccctgactt tggtttatct tctactctga catatctgca tgaagtagtt    540 
               
               
                   
               
               
                 tctgtctgaa atgtcttgaa accagggatg ttcttataat aatacttact gtgcagtgag    600 
               
               
                   
               
               
                 tggatagcca caagtaatcc ataattttac tttttaaaaa aaaaaaaaaa               650 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 112 
               
               
                 &lt;211&gt; LENGTH: 53 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 112 
               
               
                   
               
               
                 Met Arg Leu Leu Ile Thr Ile Leu Leu Glu Ile Phe Gly Glu Ile Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ser Pro Ile Lys Cys Leu Phe Val Asn Ile Leu Ile Gly Ser Val Phe 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Trp Phe Cys Lys Leu Cys Thr Phe Thr Lys His Trp Leu Phe Ser 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gly Ser Phe Gln Val 
               
               
                      50 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 113 
               
               
                 &lt;211&gt; LENGTH: 1136 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 113 
               
               
                   
               
               
                 ggaagatggc gtaccagagc ttgcggctgg agtacctgca gatcccaccg gtcagccgcg     60 
               
               
                   
               
               
                 cctacaccac tgcctgcgtc ctcaccaccg ccgccgtgca gttggaattg atcacacctt    120 
               
               
                   
               
               
                 ttcagttgta cttcaatcct gaattaatct ttaaacactt tcaaatatgg agattaatca    180 
               
               
                   
               
               
                 ccaacttctt attttttggg ccagttggat tcaatttttt atttaacatg atttttctat    240 
               
               
                   
               
               
                 atcgttactg tcgaatgcta gaagaaggct ctttccgagg tcggacagca gactttgtat    300 
               
               
                   
               
               
                 ttatgttcct ttttggtgga ttcttaatga ccctttttgg tctgtttgtg agcttagttt    360 
               
               
                   
               
               
                 tcttgggcca ggcctttaca ataatgctcg tctatgtgtg gagccgaagg aacccctatg    420 
               
               
                   
               
               
                 tccgcatgaa cttcttcggc cttctcaact tccaggcccc ctttctgccc tgggtgctca    480 
               
               
                   
               
               
                 tgggattttc cttgttgttg gggaactcaa tcattgtgga ccttttgggt attgcagttg    540 
               
               
                   
               
               
                 gacacatata ttttttcttg gaagatgtat ttcccaatca acctggtgga ataagaattc    600 
               
               
                   
               
               
                 tgaaaacacc atctattttg aaagctattt ttgatacacc agatgaggat ccaaattaca    660 
               
               
                   
               
               
                 atccactacc tgaggaacgg ccaggaggct tcgcctgggg tgagggccag cggcttggag    720 
               
               
                   
               
               
                 gttaaagcag cagtgccaat aatgagaccc agctgggaag gactcggtga tacccactgg    780 
               
               
                   
               
               
                 gatcttttat cctttgttgc aaaagtgtgg acacttttga cagcttggca gattttaact    840 
               
               
                   
               
               
                 ccagaagcac tttatgaaat ggtacactga ctaatccaga agacatttcc aacagtttgc    900 
               
               
                   
               
               
                 cagtggttcc tcactacact ggtactgaaa gtgtaatttc ttagagccaa aaaactggag    960 
               
               
                   
               
               
                 aaacaaatat cctgccacct ctaacaagta catgagtact tgatttttat gggtataagg   1020 
               
               
                   
               
               
                 cagagccttt tcttcctctt cttgatagat gaggccatgg gtgtaaatgg aagtttcaga   1080 
               
               
                   
               
               
                 gaggacaaaa taaaacggaa ttccattttt ctctcactgt aaaaaaaaaa aaaaaa       1136 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 114 
               
               
                 &lt;211&gt; LENGTH: 239 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 114 
               
               
                   
               
               
                 Met Ala Tyr Gln Ser Leu Arg Leu Glu Tyr Leu Gln Ile Pro Pro Val 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ser Arg Ala Tyr Thr Thr Ala Cys Val Leu Thr Thr Ala Ala Val Gln 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Glu Leu Ile Thr Pro Phe Gln Leu Tyr Phe Asn Pro Glu Leu Ile 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Phe Lys His Phe Gln Ile Trp Arg Leu Ile Thr Asn Phe Leu Phe Phe 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gly Pro Val Gly Phe Asn Phe Leu Phe Asn Met Ile Phe Leu Tyr Arg 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Tyr Cys Arg Met Leu Glu Glu Gly Ser Phe Arg Gly Arg Thr Ala Asp 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Phe Val Phe Met Phe Leu Phe Gly Gly Phe Leu Met Thr Leu Phe Gly 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Leu Phe Val Ser Leu Val Phe Leu Gly Gln Ala Phe Thr Ile Met Leu 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Val Tyr Val Trp Ser Arg Arg Asn Pro Tyr Val Arg Met Asn Phe Phe 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Gly Leu Leu Asn Phe Gln Ala Pro Phe Leu Pro Trp Val Leu Met Gly 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Phe Ser Leu Leu Leu Gly Asn Ser Ile Ile Val Asp Leu Leu Gly Ile 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Ala Val Gly His Ile Tyr Phe Phe Leu Glu Asp Val Phe Pro Asn Gln 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Pro Gly Gly Ile Arg Ile Leu Lys Thr Pro Ser Ile Leu Lys Ala Ile 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Phe Asp Thr Pro Asp Glu Asp Pro Asn Tyr Asn Pro Leu Pro Glu Glu 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Arg Pro Gly Gly Phe Ala Trp Gly Glu Gly Gln Arg Leu Gly Gly 
               
               
                 225                 230                 235 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 115 
               
               
                 &lt;211&gt; LENGTH: 1617 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1164) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 115 
               
               
                   
               
               
                 tgttgtgtgg gtggcatttt tcttaacgag atttgcttct gtcttagcct cacacaggga     60 
               
               
                   
               
               
                 aaatatccat ttatcttctc tctcgtgctt aattaatagc tttatctttt tttataccat    120 
               
               
                   
               
               
                 tttatccttt tctctttaac agaaagtaaa tatgtataaa atttgaagga atcgaactaa    180 
               
               
                   
               
               
                 caatacattc tgtgtatatt attttaatga agaaaataaa ttgattactg gcattggaac    240 
               
               
                   
               
               
                 agtataaaat accagtttgt acagtatgac ctatatgtga ccatgttact cccttccatt    300 
               
               
                   
               
               
                 tcacacaaag aaatagacac aactgcagtt cacaagtagt actggctcca ccccttggtg    360 
               
               
                   
               
               
                 ctggcagtgt ttggggacat tatgctggaa agagctccta gcatcagagg attaacacta    420 
               
               
                   
               
               
                 gcagattctg ttccatcttt gcactgttgc ttacctgctg attttcttaa ctgttcttgt    480 
               
               
                   
               
               
                 gcaatcgaca atgtgctaac ctgcttttct ctttttgtaa acgtttttgc attacaggct    540 
               
               
                   
               
               
                 gcattcttgc cttactgtat agaaaaagaa aaaaggctgg gtttactatt gcacatttta    600 
               
               
                   
               
               
                 agcttttata cctttatctt cttggaatgg tcagattctg aactggacag tcagaaccac    660 
               
               
                   
               
               
                 aggtctgctg ttaagggatt ttaaattgtg catttttaac cctacagtga aataacttaa    720 
               
               
                   
               
               
                 gatatccctg tgttcacagt gtgaggggct gttttatgtc atgttggcat aaattgtttt    780 
               
               
                   
               
               
                 gtaaaaggga aagtgtttct aaaggtgttt cagcgcttgt gctgatacaa agtaagttat    840 
               
               
                   
               
               
                 tactttgcac caggtggttt ggccactgaa ttaatactgt atagcaagag aaacaatctt    900 
               
               
                   
               
               
                 atttttttgg acaacatgtt ttattaagtt cttcatttct gttgattttt ttattgcatt    960 
               
               
                   
               
               
                 tatgattcag tggctgggaa ttgagaattt atttgaaata gaataggtaa cacctcagcg   1020 
               
               
                   
               
               
                 tactatagaa aatgcactca gctcaactgc tgtgtttaaa atacacattt taaatccctc   1080 
               
               
                   
               
               
                 tttacagaca ctaacataaa agtacatctt tctgggttgt aaacatgtgg tagtaccaga   1140 
               
               
                   
               
               
                 gtattgtata gtcaatgtta aatnaaagcc aaaactggaa tgtgcagaaa gtaggctttg   1200 
               
               
                   
               
               
                 gttaatttgt ggattcattt ttatttttgt ctttgtttaa ctttttaaaa aataagattt   1260 
               
               
                   
               
               
                 ctggagtaga ttggtatatt ctgttaaaga cttacagtga tccattttgc ttacactgtt   1320 
               
               
                   
               
               
                 gcatcacaag ggactcaccc agggaccatg acctgctggt gtgtgtgtat atttacaaaa   1380 
               
               
                   
               
               
                 acaaaacaaa caaaccaccc attgggatat aaggtagcaa tcacaaacta aagactgcgg   1440 
               
               
                   
               
               
                 cttgttgagg tgcaataccc tgactcccaa agttagttac agtgggtttt attgtttttg   1500 
               
               
                   
               
               
                 tgactgaagg atttattcag actgctgtac tcttcatttg atgtaacaaa atgctattaa   1560 
               
               
                   
               
               
                 tctaaatatt tgtaaataaa gtacctgtat ctagattaaa ttaaaaaaaa aaaaaaa      1617 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 116 
               
               
                 &lt;211&gt; LENGTH: 100 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 116 
               
               
                   
               
               
                 Met Leu Glu Arg Ala Pro Ser Ile Arg Gly Leu Thr Leu Ala Asp Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Val Pro Ser Leu His Cys Cys Leu Pro Ala Asp Phe Leu Asn Cys Ser 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Cys Ala Ile Asp Asn Val Leu Thr Cys Phe Ser Leu Phe Val Asn Val 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Phe Ala Leu Gln Ala Ala Phe Leu Pro Tyr Cys Ile Glu Lys Glu Lys 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Arg Leu Gly Leu Leu Leu His Ile Leu Ser Phe Tyr Thr Phe Ile Phe 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Glu Trp Ser Asp Ser Glu Leu Asp Ser Gln Asn His Arg Ser Ala 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Val Lys Gly Phe 
               
               
                             100 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 117 
               
               
                 &lt;211&gt; LENGTH: 849 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 117 
               
               
                   
               
               
                 gaataattgt tatctttaac acttggatgt tttgttttaa tcagacatcc agacctgcca     60 
               
               
                   
               
               
                 agatacttag atgactctgt ccctgggctc taaagatggg atgagtgggc ttcccacctc    120 
               
               
                   
               
               
                 actaacctgc accccacatt ttctgactag accaggcatt ctggggcagc tgcctgaggc    180 
               
               
                   
               
               
                 tgtgtgcttg ttaaggctcc aaacccacct ctctttccca ggctgggtcc ctcacacccc    240 
               
               
                   
               
               
                 tcctcttctt atgtatcacc acctgctccc ttcaaccagc ccagtttgtt cacctcttcc    300 
               
               
                   
               
               
                 tagatccacc ctccttgctc tgtttcctac atgtctgccc atccccacct ccttcaagtc    360 
               
               
                   
               
               
                 cctataaagc tcatggccat gtccattctc ctccagactt ctcccctagt aatcttaaac    420 
               
               
                   
               
               
                 acaacaataa ctaacactta ttaagcacat attacatccc aagtcctgtt actcgtttca    480 
               
               
                   
               
               
                 tttaatcctt ataactaccc gtgagggtag acttattatt aaccccattt gagagaggaa    540 
               
               
                   
               
               
                 aaaaattaag gatcgaaaag gtgaagaaac ctactcaagg tcaaacaatt tctaagtggc    600 
               
               
                   
               
               
                 aaagccaggc ttcgcattca agtctgtcat atgtatttca tgccccttat ccctatctga    660 
               
               
                   
               
               
                 tattatacta catatttatt catgtattca tttggttgtt attatctaga atgtaggctt    720 
               
               
                   
               
               
                 cctaagggca gaggttatct tatttagcat ttcctatatc agtacctgct acataattga    780 
               
               
                   
               
               
                 tgctcaataa atatttaagt gaataaatga attgatggca aaaaaaaaaa aaaaaaaaaa    840 
               
               
                   
               
               
                 aaaaaaaaa                                                            849 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 118 
               
               
                 &lt;211&gt; LENGTH: 98 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 118 
               
               
                   
               
               
                 Met Thr Leu Ser Leu Gly Ser Lys Asp Gly Met Ser Gly Leu Pro Thr 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ser Leu Thr Cys Thr Pro His Phe Leu Thr Arg Pro Gly Ile Leu Gly 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gln Leu Pro Glu Ala Val Cys Leu Leu Arg Leu Gln Thr His Leu Ser 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Phe Pro Gly Trp Val Pro His Thr Pro Pro Leu Leu Met Tyr His His 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Leu Pro Ser Thr Ser Pro Val Cys Ser Pro Leu Pro Arg Ser Thr 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Leu Ala Leu Phe Pro Thr Cys Leu Pro Ile Pro Thr Ser Phe Lys 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ser Leu 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 119 
               
               
                 &lt;211&gt; LENGTH: 925 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (883) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 119 
               
               
                   
               
               
                 cgcatcgtcg tcctccccga ccgcgtcctg cagcagctgc cagtggagcc gcctgacaag     60 
               
               
                   
               
               
                 gactgccatc caccatggtg aagctgggct gcagcttctc tgggaagcca ggtaaagacc    120 
               
               
                   
               
               
                 ctggggacca ggatggggct gccatggaca gtgtgcctct gatcagcccc ttggacatca    180 
               
               
                   
               
               
                 gccagctcca gccgccactc cctgaccagg tggtcatcaa gacacagaca gaataccagc    240 
               
               
                   
               
               
                 tgtcctcccc agaccagcag aatttccctg acctggaggg ccagaggctg aactgcagcc    300 
               
               
                   
               
               
                 acccagagga agggcgcagg ctgcccaccg cacggatgat cgccttcgcc atggcgctac    360 
               
               
                   
               
               
                 tgggctgcgt gctgatcatg tacaaggcca tctggtacga ccagttcacc tgccccgacg    420 
               
               
                   
               
               
                 gcttcctgct gcggcacaag atctgcacgc cgctgaccct ggagatgtac tacacggaga    480 
               
               
                   
               
               
                 tggaccccga gcgccaccgc agcatcctgg cggccatcgg ggcctacccg ctgagccgca    540 
               
               
                   
               
               
                 agcacggcac ggagacgccg gcggcctggg gggacggcta ccgcgcagcc aaggaggagc    600 
               
               
                   
               
               
                 gcaaggggcc cacccaggct ggggcggcgg cggcggccac cgaacccccc gggaagccgt    660 
               
               
                   
               
               
                 cggccaaggc ggagaaggag gcggcgcgga aggcggccgg gagcgcggcg cccccgcccg    720 
               
               
                   
               
               
                 cgcagtgacg tctccagccc cgcagcccgg cccgggcgtc ctccgccagc tcctgtgacc    780 
               
               
                   
               
               
                 agcgcgtctc ccgatgctct ccgccgtgtt cgtgtcccca ggcgccctcg ctgcagcccc    840 
               
               
                   
               
               
                 gcgccccgtg ggtctctgac tctgtcgctt ttctctaagt aangatttca cgtccaaaaa    900 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aaaaa                                          925 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 120 
               
               
                 &lt;211&gt; LENGTH: 217 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 120 
               
               
                   
               
               
                 Met Val Lys Leu Gly Cys Ser Phe Ser Gly Lys Pro Gly Lys Asp Pro 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Gly Asp Gln Asp Gly Ala Ala Met Asp Ser Val Pro Leu Ile Ser Pro 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Asp Ile Ser Gln Leu Gln Pro Pro Leu Pro Asp Gln Val Val Ile 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Lys Thr Gln Thr Glu Tyr Gln Leu Ser Ser Pro Asp Gln Gln Asn Phe 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Pro Asp Leu Glu Gly Gln Arg Leu Asn Cys Ser His Pro Glu Glu Gly 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Arg Arg Leu Pro Thr Ala Arg Met Ile Ala Phe Ala Met Ala Leu Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Gly Cys Val Leu Ile Met Tyr Lys Ala Ile Trp Tyr Asp Gln Phe Thr 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Cys Pro Asp Gly Phe Leu Leu Arg His Lys Ile Cys Thr Pro Leu Thr 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Leu Glu Met Tyr Tyr Thr Glu Met Asp Pro Glu Arg His Arg Ser Ile 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Leu Ala Ala Ile Gly Ala Tyr Pro Leu Ser Arg Lys His Gly Thr Glu 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Thr Pro Ala Ala Trp Gly Asp Gly Tyr Arg Ala Ala Lys Glu Glu Arg 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Lys Gly Pro Thr Gln Ala Gly Ala Ala Ala Ala Ala Thr Glu Pro Pro 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Gly Lys Pro Ser Ala Lys Ala Glu Lys Glu Ala Ala Arg Lys Ala Ala 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Gly Ser Ala Ala Pro Pro Pro Ala Gln 
               
               
                     210                 215 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 121 
               
               
                 &lt;211&gt; LENGTH: 1645 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 121 
               
               
                   
               
               
                 caaaaacctg tgactatact ttctattggg caaggctctc tactcctgtg acttctgtct     60 
               
               
                   
               
               
                 gccctgatag ctggtagcat tttcctgggt acctgccata tgccaggcac aatagaacct    120 
               
               
                   
               
               
                 tatcttcttc ccatttcaca gagaagaaag gtgaggctcg gagagggaaa gtgacttgcc    180 
               
               
                   
               
               
                 caagcttgag ctgctgggaa aaatgccagg gaccaggata cagaccttgg tcatctgact    240 
               
               
                   
               
               
                 ccaaagtccc ccgtgatgtt ttctgtgttt ggtggcctgt tggtgagggg ccctgccctc    300 
               
               
                   
               
               
                 agaacacccc tctgccagag caagatgtgt gagcacatcc ctgaagccag caagcctgca    360 
               
               
                   
               
               
                 gctagcggta tcattaccat catggtagcc ggagccaggg gtgccatctg ccagcaggga    420 
               
               
                   
               
               
                 gagaagtatg cacatctcag agtaggggtg ttagagaaac atcgccatgg ggctgacagc    480 
               
               
                   
               
               
                 caggtaggat ggcaggagtc acctggggtg aggaggggca ggtgctctag gcagaaaaaa    540 
               
               
                   
               
               
                 ccgcagcagc aaaggtgtgg aggtggaagg atcagggctc tgctgagaga atgtatagtt    600 
               
               
                   
               
               
                 ggggcttcag tgcaggagag agcactgaga gatgaggtca gaggcccgag agggagtcag    660 
               
               
                   
               
               
                 cctggggcat gcaaagctgc gaggcactgg ggagccatgg aaggttcaag caggagagag    720 
               
               
                   
               
               
                 gcctgctctg gttggtgctt caggaaactc ccccagctga caggtttgga gggcagtgtg    780 
               
               
                   
               
               
                 taagcagaga gtgaggcaag gtggcagctg caggcaggag atggttggta tgtgggccag    840 
               
               
                   
               
               
                 ggtggggtag tggggcagga gaaaagtggg cagactttgg aggcagcctc ttccctcctt    900 
               
               
                   
               
               
                 ggtgcctggg ctgactgtgg gggatgggga ggagggaaga gtgacctgga atgcccgggg    960 
               
               
                   
               
               
                 ctggcttgga tgcaatggcc ctgcccttct aaggaggtga ggaacagaaa agctaccaag   1020 
               
               
                   
               
               
                 gtctgggggt cacagataag tgtgtggggg gcctaagaga ctcccaggct gtagcacgaa   1080 
               
               
                   
               
               
                 ggctccaaga agtggtggct cagccctgtg gcccaccaga cctgattcag cttccaggcc   1140 
               
               
                   
               
               
                 cagtcgccca gccccccagt tgagtggcag ctgtcacaga acccaatgtc tccccgcacc   1200 
               
               
                   
               
               
                 atgtccaaat aaaggaaaaa ccaaaatacg tttccctttg tccgaatcca gcgagggtga   1260 
               
               
                   
               
               
                 gttgggcgag agtcatccgc tattgtgtgc tgaggcccac actgcttctt acataagccc   1320 
               
               
                   
               
               
                 cgagttaaaa atatgcccgg aattctcatt ctcaagctct gcctgggatt gcaccctgac   1380 
               
               
                   
               
               
                 ccccagcctc ggcagcttct agcacccaca gggatgaaga aactgcccca tggcacaacg   1440 
               
               
                   
               
               
                 ctggcacgtg gcacttctag ctctgtctgc ctccagtgcc acgaacagta agagtgcgcc   1500 
               
               
                   
               
               
                 gggtgcggtg ctcacgcctg taatcccagc actttgggag gccaaggtgg gcagatcact   1560 
               
               
                   
               
               
                 tgagcccagg agtttgagac cagcctgggc gaacatagca agaccccatc tctacaaaaa   1620 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aaaaa                                         1645 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 122 
               
               
                 &lt;211&gt; LENGTH: 175 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 122 
               
               
                   
               
               
                 Met Phe Ser Val Phe Gly Gly Leu Leu Val Arg Gly Pro Ala Leu Arg 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Thr Pro Leu Cys Gln Ser Lys Met Cys Glu His Ile Pro Glu Ala Ser 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Lys Pro Ala Ala Ser Gly Ile Ile Thr Ile Met Val Ala Gly Ala Arg 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gly Ala Ile Cys Gln Gln Gly Glu Lys Tyr Ala His Leu Arg Val Gly 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Val Leu Glu Lys His Arg His Gly Ala Asp Ser Gln Val Gly Trp Gln 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Glu Ser Pro Gly Val Arg Arg Gly Arg Cys Ser Arg Gln Lys Lys Pro 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Gln Gln Gln Arg Cys Gly Gly Gly Arg Ile Arg Ala Leu Leu Arg Glu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Cys Ile Val Gly Ala Ser Val Gln Glu Arg Ala Leu Arg Asp Glu Val 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Arg Gly Pro Arg Gly Ser Gln Pro Gly Ala Cys Lys Ala Ala Arg His 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Trp Gly Ala Met Glu Gly Ser Ser Arg Arg Glu Ala Cys Ser Gly Trp 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Cys Phe Arg Lys Leu Pro Gln Leu Thr Gly Leu Glu Gly Ser Val 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 123 
               
               
                 &lt;211&gt; LENGTH: 2515 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 123 
               
               
                   
               
               
                 ctttgggtaa tggaggaggt tgcagttccc gtgctgtaat tagacatctt ttaattagac     60 
               
               
                   
               
               
                 atcttttcca gcagagccat ttaaaatatt ttcctagagg acctgccccc taacctcagc    120 
               
               
                   
               
               
                 cagtcaatgg ggaggagttt tgaatgccac actccccagt ttgccaccaa accacaggca    180 
               
               
                   
               
               
                 gagagttgtg ttcatcacac tagacagaaa tctgtgtcag tcagggtcct tgcccatatg    240 
               
               
                   
               
               
                 tctccccttt gtccccctct gtacgggatt caatcaatgt ttgtcaaagc atatcattac    300 
               
               
                   
               
               
                 gtaaactgtc agaatatggt gctgagtagg aatggcaccg cgttattcat tcagtccctt    360 
               
               
                   
               
               
                 tatcgaggat ctaccatgca cctacattta tctaaatcta attattagta cacattttca    420 
               
               
                   
               
               
                 aatttgaact tctatgtgga gaggtacata aaaatataaa ttattggctg ggtgtggtgg    480 
               
               
                   
               
               
                 ctcacattta taatccttat aagcccagca ctttgggagg ccaaggtgcc tggattgctt    540 
               
               
                   
               
               
                 gagcctagga attcgaggcc agcctgggca acatggtgaa accctgtctc tacaaaaaat    600 
               
               
                   
               
               
                 ttaaaaatta gctgggcatg gtggcatgca cctgtagtcc cagctactag ggaggctgag    660 
               
               
                   
               
               
                 gtgggaagat cgcttgagcc ctggaggcag aggttgcagt gagctatgat tgtaccactg    720 
               
               
                   
               
               
                 cactctagtc tgggcaagag aagagaacct gtctcaaaaa atgtgtatat taaaaacata    780 
               
               
                   
               
               
                 taaatccttg ctcataacag aaaacagtag catatatgga aattaatcaa acctcttcca    840 
               
               
                   
               
               
                 actcttccct ctttgacaca tggaatttcc aagcaagttg tatcactggt ctactttaag    900 
               
               
                   
               
               
                 ggccatctca agtgggagac ataaaggtgt tttcccatct atgggaatat tgacaagagc    960 
               
               
                   
               
               
                 taacagaagg aatttcaaaa ggttccacag tcacagagca accaacagga agtgaaggca   1020 
               
               
                   
               
               
                 ggaagattcc tcatcaactc tattagtaca gcagaacagc aagatgaatg ttatgaagaa   1080 
               
               
                   
               
               
                 gttgagtcat tttctactgg tacttaggtc cacccggacc ttatcccttc actccccatt   1140 
               
               
                   
               
               
                 catcagccac atcctttgtg tcttgcctgc cctgctgtgg aatatgccat gagaatcatg   1200 
               
               
                   
               
               
                 tatatccagc ttcatcagct actgtcagct tgggaagacc cagtttcctt gaggttgacg   1260 
               
               
                   
               
               
                 tcctgtttca gaacaaatca ctggacttct tcagcataac atggcttttg ataagaagaa   1320 
               
               
                   
               
               
                 attctccatt tctttaagta tcctctgtag aaacagttta tataaagtcc ttggggtgac   1380 
               
               
                   
               
               
                 ctcaatccca tccacagctt caatttatga gatgatgact cagaccacat ttctggctca   1440 
               
               
                   
               
               
                 gaactttata tcaggctcca gatccatgtt ttcaaatgcc ttgaacatcc caagggtggc   1500 
               
               
                   
               
               
                 ttgaacttga actcacctca ctgcccccgc tttctgtcct aaatctaaat tttagtaaat   1560 
               
               
                   
               
               
                 tatagcatta catatctaat gataggttca caaaccagca attggaagca tccacagtag   1620 
               
               
                   
               
               
                 gtgaggcacg agcaggctgg ctttggtctg ctggaatctg gtttatttga aactaatgcc   1680 
               
               
                   
               
               
                 aagacacagc ttcctcttac tctcccaccc caggcaattg ctcttgcctt ggctgtgtcc   1740 
               
               
                   
               
               
                 tacaggctgc ctcattctcc tctcctgccc ctgcttccac ccacctggaa tcacttctcc   1800 
               
               
                   
               
               
                 aggtcataca aagcaccttt gccccacaca aggattcaag caggctgacc aacagaagtc   1860 
               
               
                   
               
               
                 atcttgagga tcttgtgaaa actatagatt cccatgctct tccccacgac cctctgattc   1920 
               
               
                   
               
               
                 tgggagtcta ggttgagacc taatccaccg tggggaccat cagagaattc agtctgtgcc   1980 
               
               
                   
               
               
                 ctagtgcaca acatgaaaaa aactatgatg ttctgtgtct ccccacaagt ttggagtact   2040 
               
               
                   
               
               
                 gttctcacaa gcattgatgg cactacacac acacatcaca cacatgcaca aatgcatcca   2100 
               
               
                   
               
               
                 cacacatgca caaatacaaa tgcatacatg tgtgacacaa atgcatttta gtcatactgt   2160 
               
               
                   
               
               
                 cactgtgccc aggtctcctt ccgttgtttc tacaaataat cattgagtaa acaatcatct   2220 
               
               
                   
               
               
                 actaagccat tcggagctcc cagctctgct cgcgcattgc cagacttgcc ccttccccct   2280 
               
               
                   
               
               
                 gatgaccacg gcaccctcct gactggtctc cctccctctg ggctgccctc tacacttctg   2340 
               
               
                   
               
               
                 acttagtggt ctttggaaat gcagattgag gtcaccgaag tgccttgacc ctacatgaag   2400 
               
               
                   
               
               
                 gtcaaacttc tcagctctga aaacagtgct tgcccagtgt ctggggcttc atttggtctg   2460 
               
               
                   
               
               
                 ccctccgaca gccgctcctc aatgcgccac caccacgaaa caaaaaaaaa aaaaa        2515 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 124 
               
               
                 &lt;211&gt; LENGTH: 93 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 124 
               
               
                   
               
               
                 Met Gly Arg Ser Phe Glu Cys His Thr Pro Gln Phe Ala Thr Lys Pro 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Gln Ala Glu Ser Cys Val His His Thr Arg Gln Lys Ser Val Ser Val 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Arg Val Leu Ala His Met Ser Pro Leu Cys Pro Pro Leu Tyr Gly Ile 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gln Ser Met Phe Val Lys Ala Tyr His Tyr Val Asn Cys Gln Asn Met 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Val Leu Ser Arg Asn Gly Thr Ala Leu Phe Ile Gln Ser Leu Tyr Arg 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly Ser Thr Met His Leu His Leu Ser Lys Ser Asn Tyr 
               
               
                                  85                  90 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 125 
               
               
                 &lt;211&gt; LENGTH: 1763 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 125 
               
               
                   
               
               
                 gcctcagcaa caaagaaaaa gtgaattttt aatgctgaag ataaagtaag ctaaagtacc     60 
               
               
                   
               
               
                 agcagaagcc ttggctattt atagcagttc tgacaatagt tttataagaa catgaagaga    120 
               
               
                   
               
               
                 acagaatcac ttgaaaatgg atgccagtca tctcttgttc ccactactga attcttataa    180 
               
               
                   
               
               
                 agtggtggca agatagggaa gggataatct gagaattttt aaaagatgat ttaatgagaa    240 
               
               
                   
               
               
                 gaagcacaat tttgattgtg atgagtcact ttctgtaaac aatcttggtc tatctttacc    300 
               
               
                   
               
               
                 cttatacctt atctgtaatt taccatttat tgtatttgca aagcgagtag gggttgaatc    360 
               
               
                   
               
               
                 acaggaaatc ctttgtattc cagactttag ggcagagcct gagggagtat tattttacat    420 
               
               
                   
               
               
                 aacccgtcct agagtaacat tttaggcaac attcttcatt gcaagtaaaa gatccataag    480 
               
               
                   
               
               
                 tggcatttta cacggctgcg agtattgtta tatctaatcc tattttaaaa gatttttggt    540 
               
               
                   
               
               
                 aatatgaagc ttgaatactg gtaacagtga tgcaatatac gcaagctgca caacctgtat    600 
               
               
                   
               
               
                 attgtatgca ttgctgcgtg gaggctgttt atttcaacct ttttaaaaat tgtgtttttt    660 
               
               
                   
               
               
                 agtaaaatgg cttatttttt cccaaaggtg gaatttagca ttttgtaatg atgaatataa    720 
               
               
                   
               
               
                 aaatacctgt catccccaga tcatttaaaa gttaactaaa gtgagaatga aaaaacaaaa    780 
               
               
                   
               
               
                 ttccaagaca ctttttaaaa gaatgtctgc cctcacacac ttttatggat ttgtttttct    840 
               
               
                   
               
               
                 tacataccca tcttttaact tagagatagc attttttgcc ctctttattt tgttgtttgt    900 
               
               
                   
               
               
                 ttctccagag agtaaacgct ttgtagttct ttctttaaaa aacatttttt ttaaagaaga    960 
               
               
                   
               
               
                 agaagccact tgaaccctca ataaaggctg ttgcctaagc atggcatact tcatctgttc   1020 
               
               
                   
               
               
                 tcatttgtgc catctgccgt gatgtcgtca cttttatggc gttaatttcc tgccactaca   1080 
               
               
                   
               
               
                 gatcttttga agattgctgg aatactggtg tctgttagaa tgcttcagac tacagatgta   1140 
               
               
                   
               
               
                 attaaaggct tttcttaata tgttttaacc aaagatgtgg agcaatccaa gccacatatc   1200 
               
               
                   
               
               
                 ttctacatca aatttttcca ttttggttat tttcataatc tggtattgca ttttgccttc   1260 
               
               
                   
               
               
                 cctgttcata cctcaaattg attcatacct cagtttaatt cagagaggtc agttaagtga   1320 
               
               
                   
               
               
                 cggattctgt tgtggtttga atgcagtacc agtgttctct tcgagcaaag tagacctggg   1380 
               
               
                   
               
               
                 tcactgtagg cataggactt ggattgcttc agatggtttg ctgtatcatt tttcttcttt   1440 
               
               
                   
               
               
                 ttcttttcct ggggacttgt ttccattaaa tgagagtaat taaaatcgct tgtaaatgag   1500 
               
               
                   
               
               
                 ggcatacatg catttgcaac aaatattcaa atagaggctc acagcggcat aagctggact   1560 
               
               
                   
               
               
                 ttgtcgccac tagatgacag gatgttataa ctaagttaaa ccacatctgt gtatctcagg   1620 
               
               
                   
               
               
                 ggacttaatt cagctgtctg tagtgaataa aagtgggaaa ttttcaaaag tttctcctgc   1680 
               
               
                   
               
               
                 tggaaataag gtataatttg ttttttgcag acaattcggt aaagttactg gctttcttgg   1740 
               
               
                   
               
               
                 tgaaaaagaa aaaaaaaaaa aaa                                           1763 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 126 
               
               
                 &lt;211&gt; LENGTH: 102 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 126 
               
               
                   
               
               
                 Met Trp Ser Asn Pro Ser His Ile Ser Ser Thr Ser Asn Phe Ser Ile 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Leu Val Ile Phe Ile Ile Trp Tyr Cys Ile Leu Pro Ser Leu Phe Ile 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Pro Gln Ile Asp Ser Tyr Leu Ser Leu Ile Gln Arg Gly Gln Leu Ser 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Asp Gly Phe Cys Cys Gly Leu Asn Ala Val Pro Val Phe Ser Ser Ser 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Lys Val Asp Leu Gly His Cys Arg His Arg Thr Trp Ile Ala Ser Asp 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly Leu Leu Tyr His Phe Ser Ser Phe Ser Phe Pro Gly Asp Leu Phe 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Pro Leu Asn Glu Ser Asn 
               
               
                             100 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 127 
               
               
                 &lt;211&gt; LENGTH: 1698 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 127 
               
               
                   
               
               
                 caaagaaaag gttggttaga ataagtaaaa tttcagttag aaagatatag cttaccagtt     60 
               
               
                   
               
               
                 ttccatgtgc ttaaggaagt caagaatatt tcaggttgtt gagaactgtt gtaaaatgga    120 
               
               
                   
               
               
                 attgaagcta gtgtctctca ccttcttagg tgtatcagag agaggaagtg gaaggccagt    180 
               
               
                   
               
               
                 agtagcatct tcatacttac ttttgccagc ccagcctcca tttcaaagac tttgtcttcc    240 
               
               
                   
               
               
                 atcctatcca atgacatggt cagggatggg ctctgaggag gcagtgaggc cccaccttgg    300 
               
               
                   
               
               
                 tttgctccac tgtggtgtgt agtctccaaa cagcttaagg gtttttaagt tttctcacga    360 
               
               
                   
               
               
                 ttacctccac tccactcatc tactatcagc atcagaaagg ttaacatccc tgggaccatt    420 
               
               
                   
               
               
                 ctacttataa aagagatgaa ctagtgtgct ttctcccctt ttccaggtgt gccatccata    480 
               
               
                   
               
               
                 tacaatctcc tcttggccaa gttcaacaaa tgtttccagg gaaccccgtg ggttgaggca    540 
               
               
                   
               
               
                 aagtagccaa gatgtattga gttaagtttt tctagaggac aaaagtattt cttgtccctt    600 
               
               
                   
               
               
                 ttccctcatg ctcatatgtt ttagctgagg cgtaaatggc caagttgagt aatatctgtg    660 
               
               
                   
               
               
                 gaactgagac agagagccag ggacccatgt acccagggac cagtcccctg gggaatcaca    720 
               
               
                   
               
               
                 cagtggctca gactagactg ctctatccca ccagaactct gctgctgttc atttccatca    780 
               
               
                   
               
               
                 ggaccaccca ggaaagcaaa taagttagcc ttctcatcat taggtcacct aatctcttgg    840 
               
               
                   
               
               
                 ggtgcaggat gagagcatat atagatctcc tgtttagaga gtgtgttcat aattgtagaa    900 
               
               
                   
               
               
                 agggatagaa aatggaataa ccaagaggct gtgtcatttt ttaagaggat ggcaaggatg    960 
               
               
                   
               
               
                 acctcaaatg agctcaacaa aactgggaat ccaaggaatg gtgcttgtag ggaaagagag   1020 
               
               
                   
               
               
                 gtcagttgtg gtccttaaac ctcttggcac cttgtgcggg ttataaaaca aggagctgga   1080 
               
               
                   
               
               
                 gtaaaattgc ccttaccccc aatccaaatg ctgtccagga tttaggagct acccaacctg   1140 
               
               
                   
               
               
                 tggttatatg gtgttggttt ccattttttg tttgtttgct tgtttccaaa atagccttgc   1200 
               
               
                   
               
               
                 ttggtactgc atggaaagtt caagcttttc ttcttgcccg ctcagggctg gcctcttccc   1260 
               
               
                   
               
               
                 cgtgtcttca cagcgtccct aaggaagatt tttgcagcac tctctggagc tgaggggagt   1320 
               
               
                   
               
               
                 gaaatttggt ccagagaagg cggaaggaaa tagttttcct gtttcctttt ctcgaggtgg   1380 
               
               
                   
               
               
                 atgtcctcag gcttccttca cacctccttc tcatgggtgc ggctggcagt acagtcaggc   1440 
               
               
                   
               
               
                 tgtggaggag ggctgagaag aaaggggcac tggtccagcc ccaggtttgg tctgagacag   1500 
               
               
                   
               
               
                 gtacacagca gataccatcc caccttcctc tctaaagaac aggccagcca cacatataac   1560 
               
               
                   
               
               
                 cctttcccta ctttactaat gtatccctta tgtggtacca gcaatggagg acaggcagac   1620 
               
               
                   
               
               
                 ttaccccctg ccatctagag agaatgttgt tattacccgt aaaacttgac caccccacga   1680 
               
               
                   
               
               
                 aacaaaaaaa aaaaaaaa                                                 1698 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 128 
               
               
                 &lt;211&gt; LENGTH: 85 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 128 
               
               
                   
               
               
                 Met Cys Leu Arg Lys Ser Arg Ile Phe Gln Val Val Glu Asn Cys Cys 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Lys Met Glu Leu Lys Leu Val Ser Leu Thr Phe Leu Gly Val Ser Glu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Arg Gly Ser Gly Arg Pro Val Val Ala Ser Ser Tyr Leu Leu Leu Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ala Gln Pro Pro Phe Gln Arg Leu Cys Leu Pro Ser Tyr Pro Met Thr 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Trp Ser Gly Met Gly Ser Glu Glu Ala Val Arg Pro His Leu Gly Leu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu His Cys Gly Val 
               
               
                                  85 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 129 
               
               
                 &lt;211&gt; LENGTH: 2110 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 129 
               
               
                   
               
               
                 agcagagaag attgaagatg tggaaatcac actggtgtga tgatgggctt gcccatccat     60 
               
               
                   
               
               
                 tactgctaca atcaaggcca ggcttggagt ttggccagtc ttgtttttta ggcacctttg    120 
               
               
                   
               
               
                 catgatgatg actcttgaac agagcaaaaa acaaggagga ttatgtgtga ctgggtggcc    180 
               
               
                   
               
               
                 tggtagactc ctcccacgtt ttgaatattt cgtgcctttt ttttttgttg tcattttcta    240 
               
               
                   
               
               
                 tgtcatttct cctaccatag cacaaatcct agcggaccct atgatcaaag aggggggcag    300 
               
               
                   
               
               
                 cctcatgcct aacagtggtc tgttttatat gaagactcaa gaacaagcct cattccaggg    360 
               
               
                   
               
               
                 cacagtccct aaattactga tcatgtgcac tcgtacagta tattactgtg accacaaggg    420 
               
               
                   
               
               
                 atgtggcaaa gattctcatc tttcttcaag tggcttttgc tcatctgatt gagaattaat    480 
               
               
                   
               
               
                 cagatcatgt tggctacata aggaaacaga aggagggatt tcaggagagg ctggctcctc    540 
               
               
                   
               
               
                 cccaaggtta gtccccagac tgagaaagtg aaaccttatt gggaaaaatt ggactgccct    600 
               
               
                   
               
               
                 gaatttagca ccaattgcat taacgcacat ctcttccaca actaacagac ttaaaataac    660 
               
               
                   
               
               
                 agtgtccttc gtattaatat ctgtgccatt catttagaat tagcagagct aatatggagg    720 
               
               
                   
               
               
                 ggctgaacta gtagccacat cttgttcatc acatagacta atagaaagga gctgtggcta    780 
               
               
                   
               
               
                 aagcagaaat ggaacttccg gatctgaaat tagcccatat aatgttcttt tgtatttggg    840 
               
               
                   
               
               
                 tatttttcat cttaattttt acagcatata ctcttcttac cagtatcctt agaatccaaa    900 
               
               
                   
               
               
                 tgtctagata agttgaggac acatacctgc attgttgagc ttctctactg gggacgcccc    960 
               
               
                   
               
               
                 ggcattattt tattcccaag ccagcagacc ggcccagaca gccaggctgt ggctggtcca   1020 
               
               
                   
               
               
                 gaccaactgc tatggtggaa aatgcagctt ccaggtccca ctaccctgac atttccgtgg   1080 
               
               
                   
               
               
                 aaggaagaac ctggtggctc gtggaggaaa ccagctttct atgagaaagg actgaaggat   1140 
               
               
                   
               
               
                 tgcgcaccct gcacaagtac agattgacca ggaaaagaca agtgtcttct gtgtgtcaca   1200 
               
               
                   
               
               
                 gggaaagcca ggagtggcct tctctgcaac cagcaagcct gcagcaacag gtgcccccac   1260 
               
               
                   
               
               
                 gtcaggtgct gactgttcgc tgtccgctcc tgtagaaagt tgggagcaca atacctatgg   1320 
               
               
                   
               
               
                 acttaaggat gttcgccggt tgtgggttgg gttttttttt tttcctgggg taagaaatcg   1380 
               
               
                   
               
               
                 aatttgcgga atttaaatct tccaggttgt ataatgcttt gaaaactcca tccctcctaa   1440 
               
               
                   
               
               
                 agaatcataa aaaaacttga aatgctcgcc aaatgtcccc catggggatt tttgaccaaa   1500 
               
               
                   
               
               
                 aggtaaggtg ataacaggag aaatttttgg ttctttgatc acttcagtga caataccctt   1560 
               
               
                   
               
               
                 taatgcatct tctccatgat ttggggtttt ttttcgttgt tgttttttac acttcttaac   1620 
               
               
                   
               
               
                 ctgttgatct atttgaggtc tttggtgttt atcaaactaa ttcttaagtt taaaaaagaa   1680 
               
               
                   
               
               
                 attaaaaggg tggttttttt aagattttaa agtttgctaa catattaaaa atcttcaaat   1740 
               
               
                   
               
               
                 gcttattaaa tagagcagtt cttgccaccc agtctggtat tctgtcttta gctagccaaa   1800 
               
               
                   
               
               
                 ttgtccttga atttgggttt tccacaacct caaagggtta tttgaaatct tttgtagtat   1860 
               
               
                   
               
               
                 tttaaaatat tttttggaag agctgctaat tttattttaa aaaacagagt tgtgaaaaca   1920 
               
               
                   
               
               
                 tgcctccttt ttaaaaaata acccctccat ccaggatatg gaatccagca ccacagtgca   1980 
               
               
                   
               
               
                 caggtcaggg ctcggaggga gcctctgtgc agatgtgctt tctttacagt ggctgtaaaa   2040 
               
               
                   
               
               
                 agtttgtatt tactatgtat aaaatgttga ataataaaaa aaatggaatt aaaaaaaaaa   2100 
               
               
                   
               
               
                 aaaaaaaaaa                                                          2110 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 130 
               
               
                 &lt;211&gt; LENGTH: 116 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 130 
               
               
                   
               
               
                 Met Met Met Thr Leu Glu Gln Ser Lys Lys Gln Gly Gly Leu Cys Val 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Thr Gly Trp Pro Gly Arg Leu Leu Pro Arg Phe Glu Tyr Phe Val Pro 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Phe Phe Phe Val Val Ile Phe Tyr Val Ile Ser Pro Thr Ile Ala Gln 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ile Leu Ala Asp Pro Met Ile Lys Glu Gly Gly Ser Leu Met Pro Asn 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ser Gly Leu Phe Tyr Met Lys Thr Gln Glu Gln Ala Ser Phe Gln Gly 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Thr Val Pro Lys Leu Leu Ile Met Cys Thr Arg Thr Val Tyr Tyr Cys 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Asp His Lys Gly Cys Gly Lys Asp Ser His Leu Ser Ser Ser Gly Phe 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Cys Ser Ser Asp 
               
               
                         115 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 131 
               
               
                 &lt;211&gt; LENGTH: 752 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 131 
               
               
                   
               
               
                 cccgtgtttc ccgggctggg tatttgcctc gcaccatggc gcccaagggc aaagtgggca     60 
               
               
                   
               
               
                 cgagagggaa gaagcagata tttgaagaga acagagagac tctgaagttc tacctgcgga    120 
               
               
                   
               
               
                 tcatactggg ggccaatgcc atttactgcc ttgtgacgtt ggtcttcttt tactcatctg    180 
               
               
                   
               
               
                 cctcattttg ggcctggttg gccctgggct ttagtctggc agtgtatggg gccagctacc    240 
               
               
                   
               
               
                 actctatgag ctcgatggca cgagcagcgt tctctgagga tggggccctg atggatggtg    300 
               
               
                   
               
               
                 gcatggacct caacatggag cagggcatgg cagagcacct taaggatgtg atcctactga    360 
               
               
                   
               
               
                 cagccatcgt gcaggtgctc agctgcttct ctctctatgt ctggtccttc tggcttctgg    420 
               
               
                   
               
               
                 ctccaggccg ggccctttac ctcctgtggg tgaatgtgct gggcccctgg ttcactgcag    480 
               
               
                   
               
               
                 acagtggcac cccagcacca gagcacaatg agaaacggca gcgccgacag gagcggcggc    540 
               
               
                   
               
               
                 agatgaagcg gttatagcca ttgacattat tgccacaggc cactggccct gggtggctct    600 
               
               
                   
               
               
                 gtcagggtgc acagcccctc atgcctggag caatgagggt ttagtccagg ggccaaaagc    660 
               
               
                   
               
               
                 agtctgaggt attgggtata cttatactct atagggtcgt tgaataaatg gcttagaatg    720 
               
               
                   
               
               
                 tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                  752 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 132 
               
               
                 &lt;211&gt; LENGTH: 173 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 132 
               
               
                   
               
               
                 Met Ala Pro Lys Gly Lys Val Gly Thr Arg Gly Lys Lys Gln Ile Phe 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Glu Glu Asn Arg Glu Thr Leu Lys Phe Tyr Leu Arg Ile Ile Leu Gly 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ala Asn Ala Ile Tyr Cys Leu Val Thr Leu Val Phe Phe Tyr Ser Ser 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ala Ser Phe Trp Ala Trp Leu Ala Leu Gly Phe Ser Leu Ala Val Tyr 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gly Ala Ser Tyr His Ser Met Ser Ser Met Ala Arg Ala Ala Phe Ser 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Glu Asp Gly Ala Leu Met Asp Gly Gly Met Asp Leu Asn Met Glu Gln 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Gly Met Ala Glu His Leu Lys Asp Val Ile Leu Leu Thr Ala Ile Val 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Gln Val Leu Ser Cys Phe Ser Leu Tyr Val Trp Ser Phe Trp Leu Leu 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Ala Pro Gly Arg Ala Leu Tyr Leu Leu Trp Val Asn Val Leu Gly Pro 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Trp Phe Thr Ala Asp Ser Gly Thr Pro Ala Pro Glu His Asn Glu Lys 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Arg Gln Arg Arg Gln Glu Arg Arg Gln Met Lys Arg Leu 
               
               
                                 165                 170 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 133 
               
               
                 &lt;211&gt; LENGTH: 698 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 133 
               
               
                   
               
               
                 ggcagccatg gtcggggcgc tgtgcggctg ctggttccgc ctgggcgggg cccgcccgct     60 
               
               
                   
               
               
                 catcccgttg ggcccgactg tggtacagac ctccatgagc cggtcccagg tagccctgct    120 
               
               
                   
               
               
                 gggcctgagt ctgctgctca tgctcctact gtatgtgggg ctgccaggcc cccctgagca    180 
               
               
                   
               
               
                 gacttcctgc ctctggggag accccaatgt cacagtcctg gctggtctca cccctggcaa    240 
               
               
                   
               
               
                 ctcgcccatc ttttaccgcg aggtgctccc acccacccag aactacaccc aggagcaatt    300 
               
               
                   
               
               
                 ctgggctgtg aagactccaa cccttatcct gtatggagag ctggaccaca tcctggctcg    360 
               
               
                   
               
               
                 agagtcactg cggcagctcc gccacctgcc caaccactct gtggtgaagc tacgcaatgc    420 
               
               
                   
               
               
                 aggccatgcc tgttacctcc acaagccgca agacttccac cttgtcctgc ttgccttcct    480 
               
               
                   
               
               
                 tgaccatcta ccttgaacta acccactccc agctcccagc ctggcatgag cttggacagt    540 
               
               
                   
               
               
                 ctggaccgcc accctccctg aaccagggag acagcctctg ggattggagg ccagaggcca    600 
               
               
                   
               
               
                 gggtcagacc cagccaggac tcctcatttc atctcacaga cacaataaaa aagcatattt    660 
               
               
                   
               
               
                 gtcctgccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                            698 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 134 
               
               
                 &lt;211&gt; LENGTH: 162 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 134 
               
               
                   
               
               
                 Met Val Gly Ala Leu Cys Gly Cys Trp Phe Arg Leu Gly Gly Ala Arg 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Pro Leu Ile Pro Leu Gly Pro Thr Val Val Gln Thr Ser Met Ser Arg 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ser Gln Val Ala Leu Leu Gly Leu Ser Leu Leu Leu Met Leu Leu Leu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Tyr Val Gly Leu Pro Gly Pro Pro Glu Gln Thr Ser Cys Leu Trp Gly 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Asp Pro Asn Val Thr Val Leu Ala Gly Leu Thr Pro Gly Asn Ser Pro 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ile Phe Tyr Arg Glu Val Leu Pro Pro Thr Gln Asn Tyr Thr Gln Glu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Gln Phe Trp Ala Val Lys Thr Pro Thr Leu Ile Leu Tyr Gly Glu Leu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Asp His Ile Leu Ala Arg Glu Ser Leu Arg Gln Leu Arg His Leu Pro 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Asn His Ser Val Val Lys Leu Arg Asn Ala Gly His Ala Cys Tyr Leu 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 His Lys Pro Gln Asp Phe His Leu Val Leu Leu Ala Phe Leu Asp His 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Leu Pro 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 135 
               
               
                 &lt;211&gt; LENGTH: 1825 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 135 
               
               
                   
               
               
                 tgtgcgttat gtaggttgta atgaagctaa cagtttcagt tatgtactac tatttttgtc     60 
               
               
                   
               
               
                 catacttagt tcattgtaaa ctctatatta atttctttga taacatgtat ttgatttttt    120 
               
               
                   
               
               
                 tgcaatacgg ctttcaggtt cttgccattc ttcagattct catgcttatt cagatttctc    180 
               
               
                   
               
               
                 atttggctgg cattttgtta tcagtgaacc aaaattatct cattttaaat tcacataaga    240 
               
               
                   
               
               
                 caaaagcacc agtagtcagt attctagttc tccttactaa tttacggagg tgtgatctgg    300 
               
               
                   
               
               
                 gtgattttta aattaattta attatcattt catattcata gtgatgattt ttaaaatttt    360 
               
               
                   
               
               
                 acaaactttt cacctatata aacatcttta ttgtcaggtg tctgacaagc taatttcttt    420 
               
               
                   
               
               
                 gctaactatt ttagttatta atatattatg taggttgtat cagaattttg tttttcaccc    480 
               
               
                   
               
               
                 aatgcttttt cacaattccc aagtcaagaa ggatgcatta caatgtttac attagcatct    540 
               
               
                   
               
               
                 aaaggcaatg taaagtcggg aaacattttt agtatataat ttcataattc aaagacattt    600 
               
               
                   
               
               
                 ttaaaaaatg aatggttaaa ccagtatctc actgcattaa atgtaattca atacattaaa    660 
               
               
                   
               
               
                 tttagttatt agaagatgtt attacaagcc tcaacatgta acatgcttac ttacaaatca    720 
               
               
                   
               
               
                 aaaatctcag atcaagtggc tggaactgca ggggcctgcc aggcatctgg gtatttacat    780 
               
               
                   
               
               
                 gattcctttc catgtggtta tggcagagca tggccatttc aaggtagtca aacttcttac    840 
               
               
                   
               
               
                 acaaaagctg gcttaccaca gagtgggtat ttcaagggag ggaaacagaa gaagcaacat    900 
               
               
                   
               
               
                 atgtataatt ggaaacccgg aggaggaaaa agagggcagt gacaccaaac agtatttaaa    960 
               
               
                   
               
               
                 tatcaaaacc tataatctga aaacatactt acaggctttt gtgttctcca tttttccctt   1020 
               
               
                   
               
               
                 agcataatac ttttaaaatt tatagatatt gttccatata tcagtagttt gttttttttt   1080 
               
               
                   
               
               
                 ttggttttgc tccgttgtgt gatgtatagt catatgttta tatagttgcc cctggataga   1140 
               
               
                   
               
               
                 cgtttgggtt ttttacattt tgggcctatt agaataaaag ctcgtgaata ttccagtaaa   1200 
               
               
                   
               
               
                 aatttgtgtg tgaatatata tttttaatct tcttgggtaa atacatagaa atgcaatttc   1260 
               
               
                   
               
               
                 tgtgtcattt gttatgatca acttcattaa aaactgcaga ctcttttcaa aatcagccat   1320 
               
               
                   
               
               
                 atcattttgc attctcagga tgttacttga caacatcacc acatttggta tggtagtttt   1380 
               
               
                   
               
               
                 tttaaatttt agtgattctg gtggatgtat agtggtattt tttagtttga atttgaattt   1440 
               
               
                   
               
               
                 ctgaaataag taatgatatt gaacttgttt tgttattgtg atttgccatt tatacattat   1500 
               
               
                   
               
               
                 cttttttgaa gtatcttaaa atcttttgtc tgttttaaaa attaggttgt tgtcttaata   1560 
               
               
                   
               
               
                 ttgagttgtg agatttattt atttcatgta agggctttat catatatata ttttataaat   1620 
               
               
                   
               
               
                 attctctccc attttatagt ttgtcttttc atttcataat gggaaattgt ccccaaatac   1680 
               
               
                   
               
               
                 acttttgttg taatctattg taatcagcat tttaatgcat agttagcatt cagtaaaatt   1740 
               
               
                   
               
               
                 aatcaatttt gactgtacaa tctagtgagt tttgacagct gtataaagca gtttcccacc   1800 
               
               
                   
               
               
                 accacgaaaa aaaaaaaaaa aaaaa                                         1825 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 136 
               
               
                 &lt;211&gt; LENGTH: 96 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 136 
               
               
                   
               
               
                 Met Lys Leu Thr Val Ser Val Met Tyr Tyr Tyr Phe Cys Pro Tyr Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Val His Cys Lys Leu Tyr Ile Asn Phe Phe Asp Asn Met Tyr Leu Ile 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Phe Leu Gln Tyr Gly Phe Gln Val Leu Ala Ile Leu Gln Ile Leu Met 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Ile Gln Ile Ser His Leu Ala Gly Ile Leu Leu Ser Val Asn Gln 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Asn Tyr Leu Ile Leu Asn Ser His Lys Thr Lys Ala Pro Val Val Ser 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ile Leu Val Leu Leu Thr Asn Leu Arg Arg Cys Asp Leu Gly Asp Phe 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 137 
               
               
                 &lt;211&gt; LENGTH: 1503 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1193) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 137 
               
               
                   
               
               
                 ccagagtcca gactgacatt acagcgcaag agtttgcaag tgtgtccagc atgcaccaac     60 
               
               
                   
               
               
                 tgtgcagaac ttggctcggt aactttgcgt ggaaaaataa agtacatttt gaagtatctt    120 
               
               
                   
               
               
                 gagggttggg tcaattgaga catttctagc attacttaat gacttgcatt gtggtttttc    180 
               
               
                   
               
               
                 tgcaagcaac tttaatgact ttttttatac cacatggtct cccagtttct agatgaatgc    240 
               
               
                   
               
               
                 aacatgatga tggtgatgat gacgatgagt ttaatcattg ttcatttatt gcctttaggg    300 
               
               
                   
               
               
                 ctgagggaaa gggaaggttt gttttttttt ctccccattt tcccccattc tgtctttctt    360 
               
               
                   
               
               
                 ttggtgactt acaccacatg taatgacgct atgactaatt ctgctcccaa gcccttgtat    420 
               
               
                   
               
               
                 cttgggcttc attttaggct catgtgtcca gatctgcatg cattgcttgc atttttctgg    480 
               
               
                   
               
               
                 tatctgaatg ttggttcctt gttccaggaa ttcaacatta atttccaaaa gtatcatggg    540 
               
               
                   
               
               
                 acttgtgaca atacaagaca tgaatctatg tataaaattt atcggccttt ctcatttacc    600 
               
               
                   
               
               
                 tgctctagta ttattgtatt gtgtgtgcgt gcgtgtgtga tgtcaggctg ccacgtaaaa    660 
               
               
                   
               
               
                 cttcagagaa aaatcttaaa agcagaccat ccttttgcat gctctattct aagtagaatg    720 
               
               
                   
               
               
                 ttcaatgtaa ctgactaaaa ttgcatgtta aagatattta ggtttttttg ttttctttat    780 
               
               
                   
               
               
                 ttttatttgt tttcagtttc ctgtatattt gcttactgtg ccgttttagt ggttttagga    840 
               
               
                   
               
               
                 taaaaatgca ctggtgaagc aaatgtagtg ccaacagaag gtgattttcc agttgtaaat    900 
               
               
                   
               
               
                 gtcatgcagc atttgaaggg actgtgtttt cttaaaaaaa aaatcacagt tacttctaaa    960 
               
               
                   
               
               
                 ccagatttca tttcttttat tgttttatgt gccaaaccac gaagtgcatt gggcttcaat   1020 
               
               
                   
               
               
                 ctctgaacac tgtagaccca ttagaagact gttccgattg ttacaaattg tagtgcctga   1080 
               
               
                   
               
               
                 aaacactctt aagctgatgg tcttaacaaa atgaaagttc tccaaagaca aaacagaaca   1140 
               
               
                   
               
               
                 attattataa caaaataatt atggttgaaa tgtctgtggt tccttggaat atntgcgctc   1200 
               
               
                   
               
               
                 tttgtgtttt tccatcatta gtgcagttgg aatgaatgtg tataggtcag aggtcttcgt   1260 
               
               
                   
               
               
                 gttcacattt taaaattagg taaatgacct catctttcaa gcttgaattc atttttaatt   1320 
               
               
                   
               
               
                 ttaattttat tttatacaat gtgtagacag ttccctgttc tctgcattta gaagtataca   1380 
               
               
                   
               
               
                 caatataaat ctgttaattc tgtaagtaat ttttataatt atgatgtaac tctatcttat   1440 
               
               
                   
               
               
                 ccttaaaaca tttaaaataa accctttatg tgcaaaaaaa aaaaaaaaaa aaaaaaaaaa   1500 
               
               
                   
               
               
                 aaa                                                                 1503 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 138 
               
               
                 &lt;211&gt; LENGTH: 174 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 138 
               
               
                   
               
               
                 Met Val Ser Gln Phe Leu Asp Glu Cys Asn Met Met Met Val Met Met 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Thr Met Ser Leu Ile Ile Val His Leu Leu Pro Leu Gly Leu Arg Glu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Arg Glu Gly Leu Phe Phe Phe Leu Pro Ile Phe Pro His Ser Val Phe 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Leu Val Thr Tyr Thr Thr Cys Asn Asp Ala Met Thr Asn Ser Ala 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Pro Lys Pro Leu Tyr Leu Gly Leu His Phe Arg Leu Met Cys Pro Asp 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu His Ala Leu Leu Ala Phe Phe Trp Tyr Leu Asn Val Gly Ser Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Phe Gln Glu Phe Asn Ile Asn Phe Gln Lys Tyr His Gly Thr Cys Asp 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Asn Thr Arg His Glu Ser Met Tyr Lys Ile Tyr Arg Pro Phe Ser Phe 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Thr Cys Ser Ser Ile Ile Val Leu Cys Val Arg Ala Cys Val Met Ser 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Gly Cys His Val Lys Leu Gln Arg Lys Ile Leu Lys Ala Asp His Pro 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Phe Ala Cys Ser Ile Leu Ser Arg Met Phe Asn Val Thr Asp 
               
               
                                 165                 170 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 139 
               
               
                 &lt;211&gt; LENGTH: 1772 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 139 
               
               
                   
               
               
                 ggttagaatc tattgctagg gagctggtgt gatcctgtgg aggagttaaa acacggtctt     60 
               
               
                   
               
               
                 tttgtattgc tggaattctt gcactgattc tttctcatct gaaggaggtg ttgctgctta    120 
               
               
                   
               
               
                 ttttttaatt ttccatcatt tggatgggac tttttgattt tttcgtcttg tttcacttga    180 
               
               
                   
               
               
                 gggtatgact gtggtgtatg ttgcgtatga tcatttggct tcatttccag gtgttttcag    240 
               
               
                   
               
               
                 ggggccaagg ctctgtatga gttccttggt tgtggatagc ttttgtgtgg tggctttctc    300 
               
               
                   
               
               
                 aaatgctgct tgttgtaaca atgtattggg tgtatgagtc aacacactgt ctcctgcagg    360 
               
               
                   
               
               
                 gctgagagtg ctgaggtctc aggaagctta tcttgtacac tagtgctatg accttttgac    420 
               
               
                   
               
               
                 agcaggattt ttatttggtg gtgctatttg gttgccattc cagtaggtgg cacttaagaa    480 
               
               
                   
               
               
                 taaaaaccag ctcacccttg agtagtctga taatgaatag aggcaacttt cctgactggg    540 
               
               
                   
               
               
                 gagatccttt tggactgcac tgaggtctct tggggaaggg gtggtgaggg ggaagttgca    600 
               
               
                   
               
               
                 ctaacttctc aacctgggcc agcaaacatg taatccactt ccctatcaca ccctagttgc    660 
               
               
                   
               
               
                 attgctcatg accttcagtt cttataaaca ttgccctttg actccctgct gcagtgtggg    720 
               
               
                   
               
               
                 tgtggactgc aggaatgccc ctttgacagc taacaccaaa gtgggctcag tgcagagcct    780 
               
               
                   
               
               
                 cttataccag tccaaagcag ataatattgc acatacgtgc cttgtattgc tgggatgctg    840 
               
               
                   
               
               
                 ccatactgtg cagaaatggg ccctatacct tgtggaagcc ttgctatggg gatcacttaa    900 
               
               
                   
               
               
                 tcaggatgca gctaccatga aagcactgaa agtaacctaa aagagagtgg cagtcagcaa    960 
               
               
                   
               
               
                 gtacacacac atcagccccc agctggagag cctctcctgt gtctgcaaga gtagatgggg   1020 
               
               
                   
               
               
                 agcaggagat gaccccctgt ccatgtccat ttctgacaca tgtaccttcc cctttagcag   1080 
               
               
                   
               
               
                 ttggtgccat gcccatgttt ttctttgtcc taagtgggct ttggtgggct gaattcttcc   1140 
               
               
                   
               
               
                 ctttccctag gggcagccca tactgagtgc tggatctcca gagatgctgc agttccctag   1200 
               
               
                   
               
               
                 agacctgctg gcccctgtgg ttgtgaaagt caaagctggt tgtggggtac gtttgcaggg   1260 
               
               
                   
               
               
                 ggtctggtga tgtggcaatt caaaggctga ggttccctgg ggagggcagt gggccacaat   1320 
               
               
                   
               
               
                 cggtgaacaa ccaatatggc acctgctgtc tcagttcagg cctaaggggt atgcaggcac   1380 
               
               
                   
               
               
                 ttctgtgtga gttggtacct ggttctctat ccctggaagt tcccagattg ccaccaacag   1440 
               
               
                   
               
               
                 catttcctgg ggtcatgaga gcacagggac tcctcaaaaa tttggtggtc agcaaattgt   1500 
               
               
                   
               
               
                 gacaggggta agaggagcag agaagcccta ccctttccgt agggctatgg gtttctcagg   1560 
               
               
                   
               
               
                 ggttgatctc tgctgcactc ctgctgcttt ccttttctgc actacagctt cattctctgg   1620 
               
               
                   
               
               
                 actctctgac agatcctggt tgtcttcctt cattttttca ttcagatttt gaccattcac   1680 
               
               
                   
               
               
                 ctataatttt gatcttattt ctgaggagaa ctggcatctg acatccctag ttagccatct   1740 
               
               
                   
               
               
                 tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                 1772 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 140 
               
               
                 &lt;211&gt; LENGTH: 90 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 140 
               
               
                   
               
               
                 Met Thr Phe Ser Ser Tyr Lys His Cys Pro Leu Thr Pro Cys Cys Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Val Gly Val Asp Cys Arg Asn Ala Pro Leu Thr Ala Asn Thr Lys Val 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gly Ser Val Gln Ser Leu Leu Tyr Gln Ser Lys Ala Asp Asn Ile Ala 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 His Thr Cys Leu Val Leu Leu Gly Cys Cys His Thr Val Gln Lys Trp 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ala Leu Tyr Leu Val Glu Ala Leu Leu Trp Gly Ser Leu Asn Gln Asp 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ala Ala Thr Met Lys Ala Leu Lys Val Thr 
               
               
                                  85                  90 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 141 
               
               
                 &lt;211&gt; LENGTH: 1067 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 141 
               
               
                   
               
               
                 gaaacatgtt agttgattat acctgaaatg gattatttat ctcatcagca agtattattt     60 
               
               
                   
               
               
                 gaataaaatg agaaatgctt aagaaaaatt gttgctctat agtaatttgg tttcgaagaa    120 
               
               
                   
               
               
                 tggaatggta actatttttt cccatcgttc ttttgagaga aggaagtgtg atgactgatg    180 
               
               
                   
               
               
                 atcttgaaaa gcccatttct gattgcacgt tgactggaat tctttctttg tgtctgtgga    240 
               
               
                   
               
               
                 ctagcgatgc tgtttgtaaa atgaagattc gggactggct catatctttt tatctaacta    300 
               
               
                   
               
               
                 gatgtcagat cttgaaatct gtattctcga agcaattctg ccacttgatc gtattcacag    360 
               
               
                   
               
               
                 gggccctggt aggctccttt agaaggacca tttctgttcc tagagcttaa ctagaattca    420 
               
               
                   
               
               
                 ttcttcactg aaaaaaaaaa aagttactta agaaagcatt tctttcctaa tctcactcaa    480 
               
               
                   
               
               
                 atctgcagaa ttatttgtaa ttagtaatac aaaatctggc caaaaggaga cttgtaaata    540 
               
               
                   
               
               
                 gcgtaaagtg gtgtcttatg ctaaacggtg gaatgtatag gcagagaagc tctttgaagt    600 
               
               
                   
               
               
                 tgtcagatga gctgggctca caagcctgat tcaaacaggc tgtcggtctc ctctcacccc    660 
               
               
                   
               
               
                 ttaatactgt gcagcccaaa ctcctaggac tcttgaacat ctgagcagtt ttgtgctttg    720 
               
               
                   
               
               
                 agccactttt tgacaaaaat ggctccattt ttccacagcg tggttttctt aaaatagttt    780 
               
               
                   
               
               
                 aatgttttat agtctcatag tagtagtgtt gctttctaag ctataaccgt cgactttatt    840 
               
               
                   
               
               
                 cttctactct gaaaaatctt tacttgtttg agtgttttta atttttataa agggagcctt    900 
               
               
                   
               
               
                 aatggattgg ttttcataat ttaatatttt ttgtatttgc tcttgtataa ttgtttttaa    960 
               
               
                   
               
               
                 cggaaagtat taaagaattg agggtggaat tcttagaacc aaagttattc ttaataaaaa   1020 
               
               
                   
               
               
                 tcaccacatg cttggaccaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                 1067 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 142 
               
               
                 &lt;211&gt; LENGTH: 79 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 142 
               
               
                   
               
               
                 Met Thr Asp Asp Leu Glu Lys Pro Ile Ser Asp Cys Thr Leu Thr Gly 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ile Leu Ser Leu Cys Leu Trp Thr Ser Asp Ala Val Cys Lys Met Lys 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ile Arg Asp Trp Leu Ile Ser Phe Tyr Leu Thr Arg Cys Gln Ile Leu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Lys Ser Val Phe Ser Lys Gln Phe Cys His Leu Ile Val Phe Thr Gly 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ala Leu Val Gly Ser Phe Arg Arg Thr Ile Ser Val Pro Arg Ala 
               
               
                  65                  70                  75 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 143 
               
               
                 &lt;211&gt; LENGTH: 1415 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1208) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 143 
               
               
                   
               
               
                 gtcaggttca ggcttttaga tgcaaataga tcttttccca tatgttttga attgctaaaa     60 
               
               
                   
               
               
                 cagaaagagt ggaaagaatt ttgaaacaaa caagacccct gacctactgg atcttcagtc    120 
               
               
                   
               
               
                 tggcctctac ctgcctcaca ggcactgctc atcccaccta ggcatggctg gatacttgag    180 
               
               
                   
               
               
                 ccatgctcca gccatgttgg cttctttcag ttcctccagt gccccttgct tcttcctgcc    240 
               
               
                   
               
               
                 acagggtctt tgcataactt tttccacttg caagtctatt ctcttttcct tcaacctctt    300 
               
               
                   
               
               
                 ccccatttgc ctaattaact tctctagatc ctctacatct cagttcaaac ttttctttgc    360 
               
               
                   
               
               
                 accagtcaca ttcgctgacc tctgtgacca ggccaacccc gtaccaaaaa tattcttccg    420 
               
               
                   
               
               
                 ccaagcattt ccagttatca ccttgcattt cttcctttga tgtttttgat ttatgtctac    480 
               
               
                   
               
               
                 atcccccacc taaccgtaag ctcctagatg aaaaagactt gttctcttta acctgctcat    540 
               
               
                   
               
               
                 tattccccta gcacctccaa gtatagttgg cccatcacac agcaggtgct taataaatat    600 
               
               
                   
               
               
                 ttgatgattt ctttaatgag tgagtgaatg aacctgttga tttcattcac cttagtctcc    660 
               
               
                   
               
               
                 ctcaaatttt ttccaaaaga gttactaata gtgtgaaagc tcttctgatg aagaatgcca    720 
               
               
                   
               
               
                 ctctgtagtt ttaactcagt aagtaagaaa gaatcataaa actcaactag ggcattgaca    780 
               
               
                   
               
               
                 aaatgaaagt acagtcaatg accaaaatcg tcccttttta atttttcttc taggaattta    840 
               
               
                   
               
               
                 agaaaagaag gcaaatttag caccagtggt ccctgtaagt gagccctagg ccatatctgg    900 
               
               
                   
               
               
                 atgcttttta ttttaggatc atttccaaac tagttacaat gatttttatt tgataaagtg    960 
               
               
                   
               
               
                 aaattcatcc caatctctag agggatactc agtctctaaa tgtttcaatg gtgccatcat   1020 
               
               
                   
               
               
                 cttattttta aaaagagtca cacttggacc tagatggtat gttaatgaat atataatata   1080 
               
               
                   
               
               
                 aggtttgaat ttttgtgtaa tttttatatt tagtttaact ttctgtttta aaaaggaagt   1140 
               
               
                   
               
               
                 ctggcatctt gagaattcta agaccgttta ccaaacttat tctgcattga agattggagt   1200 
               
               
                   
               
               
                 atgagggngt gtgggagctt ggtatcattt agtgttttat gagcaataac atgaatggta   1260 
               
               
                   
               
               
                 agataatttt aggaagtggt agacagattg gattcacttg gaacacagcc agaaaaatca   1320 
               
               
                   
               
               
                 ataaatgatt atttactaat tcagaaaaga tgatgattct aagtctttta aaatgcattt   1380 
               
               
                   
               
               
                 ttaaaaactg ttttccagtt cggcaaaaaa aaaaa                              1415 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 144 
               
               
                 &lt;211&gt; LENGTH: 98 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 144 
               
               
                   
               
               
                 Met Ala Gly Tyr Leu Ser His Ala Pro Ala Met Leu Ala Ser Phe Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ser Ser Ser Ala Pro Cys Phe Phe Leu Pro Gln Gly Leu Cys Ile Thr 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Phe Ser Thr Cys Lys Ser Ile Leu Phe Ser Phe Asn Leu Phe Pro Ile 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Cys Leu Ile Asn Phe Ser Arg Ser Ser Thr Ser Gln Phe Lys Leu Phe 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Phe Ala Pro Val Thr Phe Ala Asp Leu Cys Asp Gln Ala Asn Pro Val 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Pro Lys Ile Phe Phe Arg Gln Ala Phe Pro Val Ile Thr Leu His Phe 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Phe Leu 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 145 
               
               
                 &lt;211&gt; LENGTH: 1118 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 145 
               
               
                   
               
               
                 ggctctcctc tgggggctag aagatacttg aggcccagct tcatggggag ctcccctttg     60 
               
               
                   
               
               
                 ccccagacgc catgttgcaa acccttgaga aggatcctgg acagaggccc ttgcttttca    120 
               
               
                   
               
               
                 tctggaattc tgagtgctgc aaccttgcaa ctttggtcca gttagaattg gatcggaagc    180 
               
               
                   
               
               
                 tagtcaggca gcaggcgagc cccagttact cccagataac ctcctgcatt gctgtggttt    240 
               
               
                   
               
               
                 ctggagcttt ctgtagggtg ggcagtggga gccagggtag gtggggtagg cccgcccctg    300 
               
               
                   
               
               
                 cgagtgtctt cggcaccctc ccttccaccc cgccctgcgc gcggtgctct gcgccgacag    360 
               
               
                   
               
               
                 cccgccaacc tcttagcccc aggcccaggc cctggtggag gggagagctg ggagggctga    420 
               
               
                   
               
               
                 gctggtccag gtggcagagc cactcttgga gccccagctg gggtgggtcc agggcctgtg    480 
               
               
                   
               
               
                 ctcctgattc ccatctggag tagcctccca gagctgcttc tgggctggtg gtgtggcagt    540 
               
               
                   
               
               
                 gccatccttc atgtatttgg gttctctcca cagagggacc atctgtgttc tctccacccc    600 
               
               
                   
               
               
                 tgtctttgaa aacaaagatg ataccacgct gtacatctta gtctgcaatc tgccatcttc    660 
               
               
                   
               
               
                 acgtgacagt ctctcaagat ctttatatat gagagacata ttttcctttt taatatcttc    720 
               
               
                   
               
               
                 actgtatctc ttaggagatc tgtgattttt tttttcccaa tccgccatca tttactcaga    780 
               
               
                   
               
               
                 gtcagcatta aaaaaattta aaatttgtga gaggacaact atgtctgata aagcatgtca    840 
               
               
                   
               
               
                 tggaaggctg ggcacagcag ctcacacctg taatcccagc acttggggag accgaggcag    900 
               
               
                   
               
               
                 gcagatcatg aggtcaagag atcgagacca tcctggccaa catggtgaaa ccctgtctct    960 
               
               
                   
               
               
                 actaaaaata caaaaattat ggtggcgggt gcctgtagtt ccagctactc tggaggctga   1020 
               
               
                   
               
               
                 ggcaggagaa tcgcttaaac ctgggagcca ctgcactcca gcctggcagc aaagcgagac   1080 
               
               
                   
               
               
                 tctgtctcca aaaaaaaaaa aaaaaaaaaa aaaaaaaa                           1118 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 146 
               
               
                 &lt;211&gt; LENGTH: 143 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 146 
               
               
                   
               
               
                 Met Leu Gln Thr Leu Glu Lys Asp Pro Gly Gln Arg Pro Leu Leu Phe 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ile Trp Asn Ser Glu Cys Cys Asn Leu Ala Thr Leu Val Gln Leu Glu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Asp Arg Lys Leu Val Arg Gln Gln Ala Ser Pro Ser Tyr Ser Gln 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ile Thr Ser Cys Ile Ala Val Val Ser Gly Ala Phe Cys Arg Val Gly 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ser Gly Ser Gln Gly Arg Trp Gly Arg Pro Ala Pro Ala Ser Val Phe 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly Thr Leu Pro Ser Thr Pro Pro Cys Ala Arg Cys Ser Ala Pro Thr 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ala Arg Gln Pro Leu Ser Pro Arg Pro Arg Pro Trp Trp Arg Gly Glu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Leu Gly Gly Leu Ser Trp Ser Arg Trp Gln Ser His Ser Trp Ser Pro 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Ser Trp Gly Gly Ser Arg Ala Cys Ala Pro Asp Ser His Leu Glu 
               
               
                     130                 135                 140 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 147 
               
               
                 &lt;211&gt; LENGTH: 1582 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 147 
               
               
                   
               
               
                 ccagctcctc cgggtgcagg gtccctcctg ctgaccagcc tccagctctt cccagttctg     60 
               
               
                   
               
               
                 ggctccgcag cgagcggctt gggggcacta cctgacacag gagaccatgt ctgggcagag    120 
               
               
                   
               
               
                 ggtggctgca ggtggagtct gtggcgtgtg gcgcacaccc aggggctccc ccgatgctgg    180 
               
               
                   
               
               
                 ttactatctg ggctatggtg gccacagctg tcttgcccct cctcacggcc gtgctgggtg    240 
               
               
                   
               
               
                 ttaccgtggt cacccgcagg gacacggagg ggccaggcag agcagcccta gttcacctca    300 
               
               
                   
               
               
                 ccgggagccc ccgccagaag gtgggcacct ctgggaggga gggactgcca ggccttgggg    360 
               
               
                   
               
               
                 cttcctgtgc tgagtcagag ctggaacggg agacgcagga gccccgcagc tgcgggaggt    420 
               
               
                   
               
               
                 gcagatttgg ggctgccagg tggcgccagg tccccttggc cagcccccag cgcccctttc    480 
               
               
                   
               
               
                 ttctgtcccc agggcctcgg cttcacagga tggggctgcc agtgtcctgg gcccctcctg    540 
               
               
                   
               
               
                 ccctctgggt tctagggtgc tgcgccctgc tcctctcgct gtgggcgctg tgcacagcct    600 
               
               
                   
               
               
                 gccgcagccg gaggacgctg tagcccccag gaagagggcg cggaggcagc gggcgaggct    660 
               
               
                   
               
               
                 gcagggcagt gcgacggcgg cggaagcgca agtcggacac cagactgcac gagctgcacc    720 
               
               
                   
               
               
                 ggggcccgcg cagcagcaag ggccctgcgg cctgccagca tggatctcct gcgcccacac    780 
               
               
                   
               
               
                 tggctggagg tgtccaggga catcacggga ccgcaggcag cccccctctg ccttcccaca    840 
               
               
                   
               
               
                 ccaggagctg ccccgggctc tgccggcagc tgcagccacc gcaggtgcgc tggcctcgag    900 
               
               
                   
               
               
                 gccacctatt ccaacgtggg gctggcggcc cttcccgggg tcacctggcg gccagccctg    960 
               
               
                   
               
               
                 tggtggccga gtatgcccgc gtccagaagc gcaaagggac ccatcgcatt ccccaagagc   1020 
               
               
                   
               
               
                 cacagcaggg gaagactgag gtgaccccgg ccgctcaggt ggacgtcctg tactccaggg   1080 
               
               
                   
               
               
                 tctgcaagcc taaaaggagg gacccaggac ccaccacaga cccgctggac cccaagggcc   1140 
               
               
                   
               
               
                 agggagcgat tctggcctgg cgggtgacct ggcctaccag accctcccgc tcagggccct   1200 
               
               
                   
               
               
                 ggatgtggac agcggccccc tggaaaacgt gtatgagagc atccgggagc tgggggaccc   1260 
               
               
                   
               
               
                 tgctggcagg agcagcacgt gcggggctgg gacgccccct gcttccagct gccccagcct   1320 
               
               
                   
               
               
                 agggaggggc tggagacccc tccctgcctc cctgccctga acactcaagg acctgtgctc   1380 
               
               
                   
               
               
                 cttcctccag agtgaggccc gtcccccgcc ccgccccgcc tcacagctga cagcgccagt   1440 
               
               
                   
               
               
                 cccaggtccc cggctgccag cccgtgaggt ccgtgaggtc ctggccgctc tgacagccgc   1500 
               
               
                   
               
               
                 ggcctccccg ggctccagag aaggcccgcg tctaaataaa gcgccagcgc aggatgaaaa   1560 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aa                                            1582 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 148 
               
               
                 &lt;211&gt; LENGTH: 149 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 148 
               
               
                   
               
               
                 Met Leu Val Thr Ile Trp Ala Met Val Ala Thr Ala Val Leu Pro Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Leu Thr Ala Val Leu Gly Val Thr Val Val Thr Arg Arg Asp Thr Glu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gly Pro Gly Arg Ala Ala Leu Val His Leu Thr Gly Ser Pro Arg Gln 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Lys Val Gly Thr Ser Gly Arg Glu Gly Leu Pro Gly Leu Gly Ala Ser 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Cys Ala Glu Ser Glu Leu Glu Arg Glu Thr Gln Glu Pro Arg Ser Cys 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly Arg Cys Arg Phe Gly Ala Ala Arg Trp Arg Gln Val Pro Leu Ala 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ser Pro Gln Arg Pro Phe Leu Leu Ser Pro Gly Pro Arg Leu His Arg 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Met Gly Leu Pro Val Ser Trp Ala Pro Pro Ala Leu Trp Val Leu Gly 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Cys Cys Ala Leu Leu Leu Ser Leu Trp Ala Leu Cys Thr Ala Cys Arg 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Ser Arg Arg Thr Leu 
               
               
                 145 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 149 
               
               
                 &lt;211&gt; LENGTH: 1172 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 149 
               
               
                   
               
               
                 tttcctgggg agagctaccc gccagcttgg gctgccgtgg gcccctggct gaacaacgtc     60 
               
               
                   
               
               
                 ctgtgtctgg caggtggctg aggtcctgtg ctctggtgtg tgggtgattg ggcagggcct    120 
               
               
                   
               
               
                 gagctggaca ggggagctcc tagtagggga ggggagggga tgctgggatc taggtgacat    180 
               
               
                   
               
               
                 gcctgtccct gtctgctccc gtctgggctg ccagacgtcc ttctcttccc ggataagaag    240 
               
               
                   
               
               
                 cagaggacct tccagccacc cgcgacaggc cacaagcgtt ccacgagcga aggcgcctgg    300 
               
               
                   
               
               
                 ccacagctgc cctctggcct ctccatgatg aggtgcctcc acaacttcct gacagatggg    360 
               
               
                   
               
               
                 gtcctgcgga gggggcgttc actgaagact tccagggcct acgggcagag gtggagacca    420 
               
               
                   
               
               
                 tctccaagga actggagctt ttggacagag agctgtgcca gctgctgctg gagggcctgg    480 
               
               
                   
               
               
                 agggggtgct gcgggaccag ctggccctgc gagcccttgg acgacgcgct ggagcagggc    540 
               
               
                   
               
               
                 cagagccttg ggccggtgga gcccctggac ggtccagcag gtgctgtcct ggagtgcctg    600 
               
               
                   
               
               
                 gtgttgtcct ccggaatgct ggtgccggaa ctcgctatcc ctgttgtcta cctgctgggg    660 
               
               
                   
               
               
                 gcactgacca tgctgagtga aacgcagcac aagctgctgg cggaggcgct ggagtcgcag    720 
               
               
                   
               
               
                 accctgttgg ggccgctcga gctggtgggc agcctcttgg agcagagtgc cccgtggcag    780 
               
               
                   
               
               
                 gagcgcagca ccatgtccct gccccccggg ctcctgggga acagctgggg cgaaggagca    840 
               
               
                   
               
               
                 ccggcctggg tcttgctgga cgagtgtggc ctagagctgg gggaggacac tccccacgtg    900 
               
               
                   
               
               
                 tgctgggagc cgcaggccca gggccgcatg tgtgcactct acgcctccct ggcactgcta    960 
               
               
                   
               
               
                 tcaggactga gccaggagcc ccactagcct gtgcccgggc atggcctggc agctctccag   1020 
               
               
                   
               
               
                 cagggcagag tgtttgccca ccagctgcta gccctaggaa ggccaggagc ccagtagcca   1080 
               
               
                   
               
               
                 tgtggccagt ctaccatggg gcccaggagt tggggaaaca caataaaggt ggcatacgaa   1140 
               
               
                   
               
               
                 ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                 1172 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 150 
               
               
                 &lt;211&gt; LENGTH: 220 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 150 
               
               
                   
               
               
                 Met Met Arg Cys Leu His Asn Phe Leu Thr Asp Gly Val Leu Arg Arg 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Gly Arg Ser Leu Lys Thr Ser Arg Ala Tyr Gly Gln Arg Trp Arg Pro 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ser Pro Arg Asn Trp Ser Phe Trp Thr Glu Ser Cys Ala Ser Cys Cys 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Trp Arg Ala Trp Arg Gly Cys Cys Gly Thr Ser Trp Pro Cys Glu Pro 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Asp Asp Ala Leu Glu Gln Gly Gln Ser Leu Gly Pro Val Glu Pro 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Asp Gly Pro Ala Gly Ala Val Leu Glu Cys Leu Val Leu Ser Ser 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Gly Met Leu Val Pro Glu Leu Ala Ile Pro Val Val Tyr Leu Leu Gly 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ala Leu Thr Met Leu Ser Glu Thr Gln His Lys Leu Leu Ala Glu Ala 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Leu Glu Ser Gln Thr Leu Leu Gly Pro Leu Glu Leu Val Gly Ser Leu 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Leu Glu Gln Ser Ala Pro Trp Gln Glu Arg Ser Thr Met Ser Leu Pro 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Pro Gly Leu Leu Gly Asn Ser Trp Gly Glu Gly Ala Pro Ala Trp Val 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Leu Leu Asp Glu Cys Gly Leu Glu Leu Gly Glu Asp Thr Pro His Val 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Cys Trp Glu Pro Gln Ala Gln Gly Arg Met Cys Ala Leu Tyr Ala Ser 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Leu Ala Leu Leu Ser Gly Leu Ser Gln Glu Pro His 
               
               
                     210                 215                 220 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 151 
               
               
                 &lt;211&gt; LENGTH: 1111 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 151 
               
               
                   
               
               
                 attgaattct gccccacatg ttgacagtag agttggaact ggattcttgg gattacttat     60 
               
               
                   
               
               
                 ctaaaaaact ggagcatcag gtccatttct gttctgctgg tttggaatct tttccgtaat    120 
               
               
                   
               
               
                 gctatttatt gccaacaatg gcctctcttt gtgtccatat atgccttaca ccgtgctgac    180 
               
               
                   
               
               
                 ctgggtatca tccatgtgct ctgaagcatc caactttact ttgcaggtgc atcaatgtag    240 
               
               
                   
               
               
                 tcctgtccct gaactgagta accgtgttcc tgaaaagtac actagggaaa ttcacctgct    300 
               
               
                   
               
               
                 tgcttgtctt tgtattggca tggcacttgt gattgcacca tggagcatgc tcagagctat    360 
               
               
                   
               
               
                 taaattggtc tcccatctcc caccaggata tgaaaggtcc atatgggagg ccacgtaatc    420 
               
               
                   
               
               
                 acttattaca gtggttacat aatacactgg ctcactgcag actctcttgt tttttgatac    480 
               
               
                   
               
               
                 agtttcgtgc tggcttcatt tgccaattgt gttgtttagt tcggaagtaa gagggtcttg    540 
               
               
                   
               
               
                 agattgaggg gtagggaggg ctacactgac tgatccgtgg cttaagacag gagattatct    600 
               
               
                   
               
               
                 ctgtactcca gtggcatctc cttagccaag atgtgaaata aaaatcatag ttcgcctcat    660 
               
               
                   
               
               
                 ttaaaaattc taataaagca ctcaaacttt gaaaagcttt tacttttccc tcctactaaa    720 
               
               
                   
               
               
                 aaaaatgtat gtacctcata gccctgtgtc atttagtgtt cagcactttt gggaacatca    780 
               
               
                   
               
               
                 gttggtgaac tttaaaattt gctgtctact cactgggcac ggtggctcac acctgtaatc    840 
               
               
                   
               
               
                 ccagcacttt gggaggctga ggcaggtgga tcacctgagg tcaggagttt gagaccagcc    900 
               
               
                   
               
               
                 tgaccaacat ggtgaaaccc cgtctctact aaaaatgcag aaattaggtg ggcgcctgta    960 
               
               
                   
               
               
                 atcccagcta cttgggaggc tgaggcgaga taatcgcttg aacctgggag gcagaggttg   1020 
               
               
                   
               
               
                 cagtgagccg agattgcacc actgtcgccc accctgggtg ataagagtga aactccttct   1080 
               
               
                   
               
               
                 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                  1111 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 152 
               
               
                 &lt;211&gt; LENGTH: 99 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 152 
               
               
                   
               
               
                 Met Leu Phe Ile Ala Asn Asn Gly Leu Ser Leu Cys Pro Tyr Met Pro 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Tyr Thr Val Leu Thr Trp Val Ser Ser Met Cys Ser Glu Ala Ser Asn 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Phe Thr Leu Gln Val His Gln Cys Ser Pro Val Pro Glu Leu Ser Asn 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Arg Val Pro Glu Lys Tyr Thr Arg Glu Ile His Leu Leu Ala Cys Leu 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Cys Ile Gly Met Ala Leu Val Ile Ala Pro Trp Ser Met Leu Arg Ala 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ile Lys Leu Val Ser His Leu Pro Pro Gly Tyr Glu Arg Ser Ile Trp 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Glu Ala Thr 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 153 
               
               
                 &lt;211&gt; LENGTH: 551 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 153 
               
               
                   
               
               
                 ggctggcgtt tcccacattt ctctgtggga gggtccttga gaggacacag ggatgaaatg     60 
               
               
                   
               
               
                 gtgactctgt ccagcaccct tggacagaga agcctatgcc ggagccacct ctcactacag    120 
               
               
                   
               
               
                 gtcctgagct tggtgctgag gacgcctgga ggaatcacag agcccatctg gaacagccca    180 
               
               
                   
               
               
                 tctcctggct gggttggatc agcctctggt ttcttctcag agcactgaga aggtctggct    240 
               
               
                   
               
               
                 caaccacctc caagattcat cttgttctgt ggacacagca tctagtgaca caagacaaga    300 
               
               
                   
               
               
                 gagcaccaaa actctctagg agcacaggaa gtccttcagc tttcaggaat cagaagaggt    360 
               
               
                   
               
               
                 gtcacagctc tgaagaataa ggacttccac aagcccagga gatgagaagg ggtggaagtt    420 
               
               
                   
               
               
                 ggaggggcgg gactgggtgg agtggacatt ccaggagctg ggtgaggtaa aaacacggag    480 
               
               
                   
               
               
                 gcaggaaaat gcggagtgct ttggaaacca taaaaaaaaa aaaaaaaaaa aaaaaaaaaa    540 
               
               
                   
               
               
                 aaaaaaaaaa a                                                         551 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 154 
               
               
                 &lt;211&gt; LENGTH: 94 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 154 
               
               
                   
               
               
                 Met Pro Glu Pro Pro Leu Thr Thr Gly Pro Glu Leu Gly Ala Glu Asp 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ala Trp Arg Asn His Arg Ala His Leu Glu Gln Pro Ile Ser Trp Leu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gly Trp Ile Ser Leu Trp Phe Leu Leu Arg Ala Leu Arg Arg Ser Gly 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ser Thr Thr Ser Lys Ile His Leu Val Leu Trp Thr Gln His Leu Val 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Thr Gln Asp Lys Arg Ala Pro Lys Leu Ser Arg Ser Thr Gly Ser Pro 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ser Ala Phe Arg Asn Gln Lys Arg Cys His Ser Ser Glu Glu 
               
               
                                  85                  90 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 155 
               
               
                 &lt;211&gt; LENGTH: 888 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 155 
               
               
                   
               
               
                 gccgccgccc aggaagggga tgcggaaacc cctggctcgg tggagcggag aggcaggcgg     60 
               
               
                   
               
               
                 ggtgaggggc gttgccaggc aaagggcgag cgccgtggct ggggagccga ggacggcatg    120 
               
               
                   
               
               
                 tcccaggccc cgggagcaca gccgagccca cccaccgtgt accacgaacg gcagcgcctg    180 
               
               
                   
               
               
                 gagctgtgtg ctgtccacgc cctcaacaac gttctgcagc agcagctctt tagccaggag    240 
               
               
                   
               
               
                 gctgccgatg agatctgcaa gaggttggcc ccagactccc ggctgaaccc tcatcgcagc    300 
               
               
                   
               
               
                 ctcctgggca ccggcaacta tgatgtcaat gtgatcatgg ccgctctgca ggggctgggc    360 
               
               
                   
               
               
                 ctggccgccg tgtggtggga caggaggagg cccctgtccc agctggccct gccccaggta    420 
               
               
                   
               
               
                 ctggggctga tcctgaacct gccctcgccc gtgtcgctgg ggctgctgtc actgccgctg    480 
               
               
                   
               
               
                 cgccggcggc actgggtggc cctgcgccag gtggacggtg tctactacaa cctggactcc    540 
               
               
                   
               
               
                 aagctgcggg cgcccgaggc cctgggggat gaggacggag tcagggcctt cctggcggct    600 
               
               
                   
               
               
                 gcgctggccc agggcctgtg cgaggtgctg ctggtagtga ccaaggaggt ggaggagaag    660 
               
               
                   
               
               
                 ggcagctggc tgcggacaga ctgaccatgg ctgaccatcg gcgcccacag cgcagtccct    720 
               
               
                   
               
               
                 gcgcatcccc ctccggtgcg cacactgcat gcctgggaaa ggccagcact tcatggaccc    780 
               
               
                   
               
               
                 tggggaggcc ccgccccctc cccacacccc tgctccccac tgccgctgct gcctcaataa    840 
               
               
                   
               
               
                 atctgctgat ttgctgccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                 888 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 156 
               
               
                 &lt;211&gt; LENGTH: 188 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 156 
               
               
                   
               
               
                 Met Ser Gln Ala Pro Gly Ala Gln Pro Ser Pro Pro Thr Val Tyr His 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Glu Arg Gln Arg Leu Glu Leu Cys Ala Val His Ala Leu Asn Asn Val 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Gln Gln Gln Leu Phe Ser Gln Glu Ala Ala Asp Glu Ile Cys Lys 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Arg Leu Ala Pro Asp Ser Arg Leu Asn Pro His Arg Ser Leu Leu Gly 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Thr Gly Asn Tyr Asp Val Asn Val Ile Met Ala Ala Leu Gln Gly Leu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly Leu Ala Ala Val Trp Trp Asp Arg Arg Arg Pro Leu Ser Gln Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ala Leu Pro Gln Val Leu Gly Leu Ile Leu Asn Leu Pro Ser Pro Val 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ser Leu Gly Leu Leu Ser Leu Pro Leu Arg Arg Arg His Trp Val Ala 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Leu Arg Gln Val Asp Gly Val Tyr Tyr Asn Leu Asp Ser Lys Leu Arg 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Ala Pro Glu Ala Leu Gly Asp Glu Asp Gly Val Arg Ala Phe Leu Ala 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Ala Ala Leu Ala Gln Gly Leu Cys Glu Val Leu Leu Val Val Thr Lys 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Glu Val Glu Glu Lys Gly Ser Trp Leu Arg Thr Asp 
               
               
                             180                 185 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 157 
               
               
                 &lt;211&gt; LENGTH: 659 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 157 
               
               
                   
               
               
                 gaaacactga atatttcaac agcagaaatt gaatgggggg attgatagcg ctggcgaggg     60 
               
               
                   
               
               
                 aagcagctgg aaagagacag atggcaccct gagacagccc agaggtgaat aggaccccca    120 
               
               
                   
               
               
                 ggctgcaggg ataaagctca gtggtggtgt tacctcaccg gggaccaggg tcacacagca    180 
               
               
                   
               
               
                 aagctggaac aacagaggcg tgttgtgggg gagcctcaga ggggacaaaa cctctgcctg    240 
               
               
                   
               
               
                 agatcccacc ccaggtgggc atgggggcca ctgaggttgg ggatgaaaat gccggtaccg    300 
               
               
                   
               
               
                 tcagtgcaca gccctgttcc agacagtgct gcctggaaga tttctgggct ctcctgaggc    360 
               
               
                   
               
               
                 gccaccccgc acctgagcca cctccttgga ctcctgtcct ctaccccttg aggacctccc    420 
               
               
                   
               
               
                 tcccttctac cctagctgtc ttcttgaact tgggactctc ctttcccaag acttccatca    480 
               
               
                   
               
               
                 ctagctcctg gagggactgg actttgcatc ttcccttcgc gtggagcctc agtgtgagag    540 
               
               
                   
               
               
                 gccctgccaa tgcgtgcatg tcagaggtgg tggggaccac atcagaagaa gaggggggtg    600 
               
               
                   
               
               
                 atgaaattaa caaataaaaa gtatggggaa acaaaaaaaa aaaaaaaaaa aaaaaaaaa     659 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 158 
               
               
                 &lt;211&gt; LENGTH: 118 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 158 
               
               
                   
               
               
                 Met Gly Ala Thr Glu Val Gly Asp Glu Asn Ala Gly Thr Val Ser Ala 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Gln Pro Cys Ser Arg Gln Cys Cys Leu Glu Asp Phe Trp Ala Leu Leu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Arg Arg His Pro Ala Pro Glu Pro Pro Pro Trp Thr Pro Val Leu Tyr 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Pro Leu Arg Thr Ser Leu Pro Ser Thr Leu Ala Val Phe Leu Asn Leu 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gly Leu Ser Phe Pro Lys Thr Ser Ile Thr Ser Ser Trp Arg Asp Trp 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Thr Leu His Leu Pro Phe Ala Trp Ser Leu Ser Val Arg Gly Pro Ala 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Asn Ala Cys Met Ser Glu Val Val Gly Thr Thr Ser Glu Glu Glu Gly 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Gly Asp Glu Ile Asn Lys 
               
               
                         115 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 159 
               
               
                 &lt;211&gt; LENGTH: 550 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 159 
               
               
                   
               
               
                 ccttgagtct ccgggccgcc ttgccatggc tgcccgtggt gtcatcgctc cagttggcga     60 
               
               
                   
               
               
                 gagtttgcgc tacgctgagt acttgcagcc ctcggccaaa cggccagacg ccgacgtcga    120 
               
               
                   
               
               
                 ccagcagaga ctggtaagaa gtttgatagc tgtaggcctg ggtgttgcag ctcttgcatt    180 
               
               
                   
               
               
                 tgcaggtcgc tacgcatttc ggatctggaa acctctagaa caagttatca cagaaactgc    240 
               
               
                   
               
               
                 aaagaagatt tcaactccta gcttttcatc ctactataaa ggaggatttg aacagaaaat    300 
               
               
                   
               
               
                 gagtaggcga gaagctggtc ttattttagg tgtaagccca tctgctggca aggctaagat    360 
               
               
                   
               
               
                 tagaacagct cataggagag tcatgatttt gaatcaccca gataaaggtg gatctcctta    420 
               
               
                   
               
               
                 cgtagcagcc aaaataaatg aagcaaaaga cttgctagaa acaaccacca aacattgatg    480 
               
               
                   
               
               
                 cttaaggacc acactgaagg aaaaaaaaag aggggactcc aaaaaaaaaa aaaaaaaaaa    540 
               
               
                   
               
               
                 aaaaaaaaaa                                                           550 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 160 
               
               
                 &lt;211&gt; LENGTH: 150 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 160 
               
               
                   
               
               
                 Met Ala Ala Arg Gly Val Ile Ala Pro Val Gly Glu Ser Leu Arg Tyr 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ala Glu Tyr Leu Gln Pro Ser Ala Lys Arg Pro Asp Ala Asp Val Asp 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gln Gln Arg Leu Val Arg Ser Leu Ile Ala Val Gly Leu Gly Val Ala 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ala Leu Ala Phe Ala Gly Arg Tyr Ala Phe Arg Ile Trp Lys Pro Leu 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Glu Gln Val Ile Thr Glu Thr Ala Lys Lys Ile Ser Thr Pro Ser Phe 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ser Ser Tyr Tyr Lys Gly Gly Phe Glu Gln Lys Met Ser Arg Arg Glu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ala Gly Leu Ile Leu Gly Val Ser Pro Ser Ala Gly Lys Ala Lys Ile 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Arg Thr Ala His Arg Arg Val Met Ile Leu Asn His Pro Asp Lys Gly 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Gly Ser Pro Tyr Val Ala Ala Lys Ile Asn Glu Ala Lys Asp Leu Leu 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Glu Thr Thr Thr Lys His 
               
               
                 145                 150 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 161 
               
               
                 &lt;211&gt; LENGTH: 622 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 161 
               
               
                   
               
               
                 ctcacctgtg ctgccacttc ctagtgcaca cctcacggct catcctcaag ctggaagata     60 
               
               
                   
               
               
                 cctctctggc cccggcacat gtcacccctg cactcctgcc ttcccgtggg cacttccaca    120 
               
               
                   
               
               
                 tcctctgggc ctctggcagt tcccagggac tgttttcacc tctgctgtct ctggggtcag    180 
               
               
                   
               
               
                 ctgctgctca tcagctgccc gctagcatgt ggccaggggt gcagggtggc ggggggtcag    240 
               
               
                   
               
               
                 cagcatgtcc ctgggcaggc cctgggcacc ctgtctcccc tggtctcact gctgacctgg    300 
               
               
                   
               
               
                 gctggtccca gcctggattg gcctcatcca ggatctttgg tcaccccacg ctgccccatc    360 
               
               
                   
               
               
                 ttgcctgctg ttccagttct ggtcaagggc cttgggggct ggccccccac caggccttct    420 
               
               
                   
               
               
                 agagcagcac cagtctcagg gccctgggac cagctgccct acttcccagg tttgtagcca    480 
               
               
                   
               
               
                 ggagaagggg gcatcacaga gctgatggtc caataagggg ggtgtgagcc ccgcagggac    540 
               
               
                   
               
               
                 tggcccgcac ctgccttgga tgttttcagc aattaaactt ttttaagctg acaaaaaaaa    600 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aa                                             622 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 162 
               
               
                 &lt;211&gt; LENGTH: 132 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 162 
               
               
                   
               
               
                 Met Ser Pro Leu His Ser Cys Leu Pro Val Gly Thr Ser Thr Ser Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Gly Pro Leu Ala Val Pro Arg Asp Cys Phe His Leu Cys Cys Leu Trp 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gly Gln Leu Leu Leu Ile Ser Cys Pro Leu Ala Cys Gly Gln Gly Cys 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Arg Val Ala Gly Gly Gln Gln His Val Pro Gly Gln Ala Leu Gly Thr 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Ser Pro Leu Val Ser Leu Leu Thr Trp Ala Gly Pro Ser Leu Asp 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Trp Pro His Pro Gly Ser Leu Val Thr Pro Arg Cys Pro Ile Leu Pro 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ala Val Pro Val Leu Val Lys Gly Leu Gly Gly Trp Pro Pro Thr Arg 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Pro Ser Arg Ala Ala Pro Val Ser Gly Pro Trp Asp Gln Leu Pro Tyr 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Phe Pro Gly Leu 
               
               
                     130 
               
               
                   
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 163 
               
               
                 &lt;211&gt; LENGTH: 596 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 163 
               
               
                   
               
               
                 ctcgcttctc tgcattacac gccggtcagg attcgcgacc cgacatggag cgtccccgca     60 
               
               
                   
               
               
                 gtccccaatg ctcggccccg gcctctgcct cagcttcggt taccctggcg cagctcctgc    120 
               
               
                   
               
               
                 agctggtcca gcagggccag gaactcccgg gcctggagaa acgccacatc gcggcgatcc    180 
               
               
                   
               
               
                 acggcgaacc cacagcgtcc cggctgccgc ggaggcccaa gccctgggag gccgcggctt    240 
               
               
                   
               
               
                 tggctgagtc ccttccccct ccgaccctca ggataggaac ggccccggcg gagcctggct    300 
               
               
                   
               
               
                 tggttgaggc agcgactgcg ccttcttcat ggcatacagt gggcccctga ggttccaggt    360 
               
               
                   
               
               
                 cctttgcggc ggcgatctgg agggcgtggc tacaggaccc gggatgccat tcagttactc    420 
               
               
                   
               
               
                 atcttttatg ctttcgtcct gacctgtctc aactagactt gctcctgcaa ccaccatggg    480 
               
               
                   
               
               
                 ggttttgcat ttacatttgt ggaccatgtt acagttaaga aaaatcctgt ttcagtcctt    540 
               
               
                   
               
               
                 atatgtaata aaatgtttta tgatggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa        596 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 164 
               
               
                 &lt;211&gt; LENGTH: 101 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 164 
               
               
                   
               
               
                 Met Glu Arg Pro Arg Ser Pro Gln Cys Ser Ala Pro Ala Ser Ala Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ala Ser Val Thr Leu Ala Gln Leu Leu Gln Leu Val Gln Gln Gly Gln 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Glu Leu Pro Gly Leu Glu Lys Arg His Ile Ala Ala Ile His Gly Glu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Pro Thr Ala Ser Arg Leu Pro Arg Arg Pro Lys Pro Trp Glu Ala Ala 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ala Leu Ala Glu Ser Leu Pro Pro Pro Thr Leu Arg Ile Gly Thr Ala 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Pro Ala Glu Pro Gly Leu Val Glu Ala Ala Thr Ala Pro Ser Ser Trp 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 His Thr Val Gly Pro 
               
               
                             100 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 165 
               
               
                 &lt;211&gt; LENGTH: 670 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 165 
               
               
                   
               
               
                 cttagaaagc ggcggtgagg tcagcttcac attctcagga actctccttc tttgggtctg     60 
               
               
                   
               
               
                 gctgaagttg aggatctctt actctctagg ccacggaatt aacccgagca ggcatggagg    120 
               
               
                   
               
               
                 cctctgctct cacctcatca gcagtgacca gtgtggccaa agtggtcagg gtggcctctg    180 
               
               
                   
               
               
                 gctctgccgt agttttgccc ctggccagga ttgctacagt tgtgattgga ggagttgtgg    240 
               
               
                   
               
               
                 ctgtgcccat ggtgctcagt gccatgggct tcactgcggg gggaatcgcc tcgtcctcca    300 
               
               
                   
               
               
                 tagcagccaa gatgatgtcc gcggcggcca ttgccaatgg gggtggagtt gcctcgggca    360 
               
               
                   
               
               
                 gccttgtggc tactctgcag tcactgggag caactggact ctccggattg accaagttca    420 
               
               
                   
               
               
                 tcctgggctc cattgggtct gccattgcgg ctgtcattgc gaggttctac tagctccctg    480 
               
               
                   
               
               
                 cccctcgccc tgcagagaag agaaccatgc caggggagaa ggcacccagc catcctgacc    540 
               
               
                   
               
               
                 cagcgaggag ccaactatcc caaatatacc tggggtgaaa tataccaaat tctgcatctc    600 
               
               
                   
               
               
                 cagaggaaaa taagaaataa agatgaattg ttgcaactat aaaaaaaaaa aaaaaaaaaa    660 
               
               
                   
               
               
                 aaaaaaaaaa                                                           670 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 166 
               
               
                 &lt;211&gt; LENGTH: 119 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 166 
               
               
                   
               
               
                 Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ile Ala Thr Val Val Ile Gly Gly Val Val Ala Val Pro Met Val Leu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ser Ala Met Gly Phe Thr Ala Gly Gly Ile Ala Ser Ser Ser Ile Ala 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly Gly Val Ala 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ser Gly Ser Leu Val Ala Thr Leu Gln Ser Leu Gly Ala Thr Gly Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ser Gly Leu Thr Lys Phe Ile Leu Gly Ser Ile Gly Ser Ala Ile Ala 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ala Val Ile Ala Arg Phe Tyr 
               
               
                         115 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 167 
               
               
                 &lt;211&gt; LENGTH: 850 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 167 
               
               
                   
               
               
                 caaacttaca cagtgctttg ggaattccaa agtactcagt ggagagaggt gtttcaggag     60 
               
               
                   
               
               
                 ccgtagagcc agatcgtcat catgtctgca ttgtggctgc tgctgggcct ccttgccctg    120 
               
               
                   
               
               
                 atggacttgt ctgaaagcag caactgggga tgctatggaa acatccaaag cctggacacc    180 
               
               
                   
               
               
                 cctggagcat cttgtgggat tggaagacgt cacggcctga actactgtgg agttcgtgct    240 
               
               
                   
               
               
                 tctgaaaggc tggctgaaat agacatgcca tacctcctga aatatcaacc catgatgcaa    300 
               
               
                   
               
               
                 accattggcc aaaagtactg catggatcct gccgtgatcg ctggtgtctt gtccaggaag    360 
               
               
                   
               
               
                 tctcccggtg acaaaattct ggtcaacatg ggcgatagga ctagcatggt gcaggaccct    420 
               
               
                   
               
               
                 ggctctcaag ctcccacatc ctggattagt gagtctcagg tttcccagac aactgaagtt    480 
               
               
                   
               
               
                 ctgactacta gaatcaaaga aatccagagg aggtttccaa cctggacccc tgaccagtac    540 
               
               
                   
               
               
                 ctgagaggtg gactctgtgc ctacagtggg ggtgctggct atgtccgaag cagccaggac    600 
               
               
                   
               
               
                 ctgagctgtg acttctgcaa tgatgtcctt gcacgagcca agtacctcaa gagacatggc    660 
               
               
                   
               
               
                 ttctaacatc tcagatgaaa cccaagacca tgatcacata tgcagcctca aatgttacac    720 
               
               
                   
               
               
                 agataaaact agccaagggc acctgtaact gggaatctga gtttgaccta aaagtcatta    780 
               
               
                   
               
               
                 aaataacatg aatcacatta aaggaagaat tttgacctgc aaaaaaaaaa aaaaaaaaaa    840 
               
               
                   
               
               
                 aaaaaaaaaa                                                           850 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 168 
               
               
                 &lt;211&gt; LENGTH: 194 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 168 
               
               
                   
               
               
                 Met Ser Ala Leu Trp Leu Leu Leu Gly Leu Leu Ala Leu Met Asp Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ser Glu Ser Ser Asn Trp Gly Cys Tyr Gly Asn Ile Gln Ser Leu Asp 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Thr Pro Gly Ala Ser Cys Gly Ile Gly Arg Arg His Gly Leu Asn Tyr 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Cys Gly Val Arg Ala Ser Glu Arg Leu Ala Glu Ile Asp Met Pro Tyr 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Leu Lys Tyr Gln Pro Met Met Gln Thr Ile Gly Gln Lys Tyr Cys 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Met Asp Pro Ala Val Ile Ala Gly Val Leu Ser Arg Lys Ser Pro Gly 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Asp Lys Ile Leu Val Asn Met Gly Asp Arg Thr Ser Met Val Gln Asp 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Pro Gly Ser Gln Ala Pro Thr Ser Trp Ile Ser Glu Ser Gln Val Ser 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Gln Thr Thr Glu Val Leu Thr Thr Arg Ile Lys Glu Ile Gln Arg Arg 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Phe Pro Thr Trp Thr Pro Asp Gln Tyr Leu Arg Gly Gly Leu Cys Ala 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Tyr Ser Gly Gly Ala Gly Tyr Val Arg Ser Ser Gln Asp Leu Ser Cys 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Asp Phe Cys Asn Asp Val Leu Ala Arg Ala Lys Tyr Leu Lys Arg His 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Gly Phe 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 169 
               
               
                 &lt;211&gt; LENGTH: 494 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 169 
               
               
                   
               
               
                 gccagtgctt ctaattttga cttagtttca tacagtaaag cctaaatgtg aaacgcacac     60 
               
               
                   
               
               
                 gctggaagat attgttccta tcaatatttt gctttttata acaagggttt gttcatattg    120 
               
               
                   
               
               
                 atgccatttt tgcaggattt cttcgtgatt tctgtccata tgaaaatgct gacattaaac    180 
               
               
                   
               
               
                 attaacacat ggagaccgtg ccctgtggcc ctgccgtggc tgccagcatg gtctgtgttt    240 
               
               
                   
               
               
                 ccttgtggat tcacctgtgg ccctgctgtg gccaccagca tggtctgtgt cctcgtggat    300 
               
               
                   
               
               
                 tcactgcagc tgtcggatgc gagtttctgt cataatcatt tgtttcctga tacaattgtt    360 
               
               
                   
               
               
                 cttattcttt tccaaaactg taaaataatc tcctccctca aatgcaaagg ttgtttttgt    420 
               
               
                   
               
               
                 tctgtttctg ttttctttga aataaaatta taacgttaaa agacaaaaaa aaaaaaaaaa    480 
               
               
                   
               
               
                 aaaaaaaaaa aaaa                                                      494 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 170 
               
               
                 &lt;211&gt; LENGTH: 110 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 170 
               
               
                   
               
               
                 Met Pro Phe Leu Gln Asp Phe Phe Val Ile Ser Val His Met Lys Met 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Leu Thr Leu Asn Ile Asn Thr Trp Arg Pro Cys Pro Val Ala Leu Pro 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Trp Leu Pro Ala Trp Ser Val Phe Pro Cys Gly Phe Thr Cys Gly Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ala Val Ala Thr Ser Met Val Cys Val Leu Val Asp Ser Leu Gln Leu 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ser Asp Ala Ser Phe Cys His Asn His Leu Phe Pro Asp Thr Ile Val 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Ile Leu Phe Gln Asn Cys Lys Ile Ile Ser Ser Leu Lys Cys Lys 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Gly Cys Phe Cys Ser Val Ser Val Phe Phe Glu Ile Lys Leu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 171 
               
               
                 &lt;211&gt; LENGTH: 2262 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 171 
               
               
                   
               
               
                 gtgctcagtg ttcacgctat atcccttggg caatgtgggg ttggatgggg cccccacttc     60 
               
               
                   
               
               
                 cattcccatg gaaggaggcc aggtccccag ccacctccca ctcagccatg cacgcacttg    120 
               
               
                   
               
               
                 ctgggctggc ctcctgggaa acacaggtga ctcgaatgaa ctctgcattt tcaacgtgcc    180 
               
               
                   
               
               
                 ttctactgct tcaggacctg ggggtccccc tgaccctcac tggcttgccc ccagccctgg    240 
               
               
                   
               
               
                 gcctggcccc acctgtcctg gagcccagag cccctggcct ggagctgcct ctctggggtg    300 
               
               
                   
               
               
                 ggtctcaggc cccacccctc cctcttttga gttcagtgcc ttgctcagcc cctcccatgt    360 
               
               
                   
               
               
                 atctcagcgt cttcagacct ctgacagagc gacgatgtag ggtctcccgg ggcccaaggt    420 
               
               
                   
               
               
                 ggtctcaggg tcaggggtgg gatttgcagg gaactcgggg agcccacggg ttgcgccacc    480 
               
               
                   
               
               
                 tctgccctgg cagctgaagc ctgggagagt ccctgcgtgg tgtaattggc ctcagcccgc    540 
               
               
                   
               
               
                 tttctctgtg ccgtcgcacc tcagtgtttc tcatagcttg tccccacgtg tcactttcca    600 
               
               
                   
               
               
                 tccacgggaa aaacaaatgc cccttctcca tctatcattg cgacttcctc ccaggaggcc    660 
               
               
                   
               
               
                 tctcaggttg ggtagagcag gggcctgcag tggtcaggcc aagagcaagg aagacctggc    720 
               
               
                   
               
               
                 tgccccactg tggctgaaaa ctcaaaacat ctggaactac ccttctccaa ttacgttccc    780 
               
               
                   
               
               
                 tcttgcttaa agacaaagct aattaaatca tcctgccacc cgaggctcca aaccaaatct    840 
               
               
                   
               
               
                 tggacgcaaa ttaatgagtt tgataagccc aggttgattg atgagacagt ctggaaccgc    900 
               
               
                   
               
               
                 caagccatgg agtcggtggc cgtgttcccg gccctggagg gaactggcca gcagtgacca    960 
               
               
                   
               
               
                 catcgatgat gccgagtggg gaccctcacc actgcggtgg tcaagctgct tggctcctca   1020 
               
               
                   
               
               
                 gtgtcctcgt gctgtaagtc agatgaggtc accttcctct ccatcgatgc caggcttctg   1080 
               
               
                   
               
               
                 ccgctgacgg ccaatggggc ttggggccag gggcagagaa ccccaacagc aagagagccc   1140 
               
               
                   
               
               
                 caggtgatgc tggctctcca cgtgcatccg gcacgtttca ctgcagccat catcaacttg   1200 
               
               
                   
               
               
                 gcaaagtagg caagctcagc ttgtggtttc cattttgcag atgggccccc ggggtcagtg   1260 
               
               
                   
               
               
                 atgggaagag cagaagagga tgccagccca gcctggccca ggagcaggtg tcgttgtgga   1320 
               
               
                   
               
               
                 ggaaagctta aactcaacag cctctaccca acatctgcca cctgcatggc cccagatgcc   1380 
               
               
                   
               
               
                 cccggtgcag gccaggtcaa ggtgggagta aactttcttt gcctccctcc ccacagaagc   1440 
               
               
                   
               
               
                 accagaccca cttgagcccc agagcctcat gccagcagct cctggctgtt cctcacctga   1500 
               
               
                   
               
               
                 ggctagagca gcagctgcca gcttatagat ggggcggctg gcaggtgata gaatgggaag   1560 
               
               
                   
               
               
                 cattggtggg tggtggaggt gggcagtggc accatgacgg gcccctagcc aaacagctgt   1620 
               
               
                   
               
               
                 cctcaatacg gggcagggag cagccttggc aacaggcaaa ggccagagtc agagtggtgg   1680 
               
               
                   
               
               
                 ggaggacagg ggctgctgcc ccgctcctgg aaagccactg cagaggggca gtggctggca   1740 
               
               
                   
               
               
                 gtgccaggcc tgggggaagt ggaagcgtcc tgtctggggg cagattccca agcaaggtga   1800 
               
               
                   
               
               
                 cccatggtta agggccactg gaaagctgga gagagcttgg gatcccttcc acctggggcc   1860 
               
               
                   
               
               
                 aatggtgttg attgcagact ggaggggtaa cctccgctga gggtcattat gtgccaggca   1920 
               
               
                   
               
               
                 tggcattggg tactttctgc attgggacca ggcagccggg cctgccattt gaggcagcga   1980 
               
               
                   
               
               
                 gcctccgtga cctgtcctcc ctcatttgta aagtggggta acagctatgt cactggccag   2040 
               
               
                   
               
               
                 ttgtggggat taaagtgctg agctatagtg cccagcccaa aatgctcaat aaagctattc   2100 
               
               
                   
               
               
                 agtgatgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2160 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2220 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                      2262 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 172 
               
               
                 &lt;211&gt; LENGTH: 154 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 172 
               
               
                   
               
               
                 Met Trp Gly Trp Met Gly Pro Pro Leu Pro Phe Pro Trp Lys Glu Ala 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Arg Ser Pro Ala Thr Ser His Ser Ala Met His Ala Leu Ala Gly Leu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ala Ser Trp Glu Thr Gln Val Thr Arg Met Asn Ser Ala Phe Ser Thr 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Cys Leu Leu Leu Leu Gln Asp Leu Gly Val Pro Leu Thr Leu Thr Gly 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Pro Pro Ala Leu Gly Leu Ala Pro Pro Val Leu Glu Pro Arg Ala 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Pro Gly Leu Glu Leu Pro Leu Trp Gly Gly Ser Gln Ala Pro Pro Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Pro Leu Leu Ser Ser Val Pro Cys Ser Ala Pro Pro Met Tyr Leu Ser 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Val Phe Arg Pro Leu Thr Glu Arg Arg Cys Arg Val Ser Arg Gly Pro 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Arg Trp Ser Gln Gly Gln Gly Trp Asp Leu Gln Gly Thr Arg Gly Ala 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 His Gly Leu Arg His Leu Cys Pro Gly Ser 
               
               
                 145                 150 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 173 
               
               
                 &lt;211&gt; LENGTH: 2538 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 173 
               
               
                   
               
               
                 gaaaagtgga gatagttcct gtctcatgga ttgctagggg gattaagagg agtgcctgta     60 
               
               
                   
               
               
                 gaacacatag ctcaggtgct agtgcacagc aggtgtgtcc cagaggtgag ctgtggttgt    120 
               
               
                   
               
               
                 tagtctttgt gagtggagag ctgggctagg tcccaggcct gactctgtct gatgttgttt    180 
               
               
                   
               
               
                 ctcctctgca ctgtagtact ttattcccag attctgcttt ttaattcttt tttggtgtaa    240 
               
               
                   
               
               
                 ttacaagaat aaggactttg gggtcaaact gaggcttgag ctgcagagat ggaggatgca    300 
               
               
                   
               
               
                 ggtctggctg gtgggcatag tggtttcccc tagggctggg ggaggttggg gagggaggag    360 
               
               
                   
               
               
                 ggtgtgggct gcctcggtgc atctctctga caggtcctgg ccctgggtca gtccaagatg    420 
               
               
                   
               
               
                 cttgttcagc ctgtggagtc cagtaggatg agggttgtct gtcgagtggg tctggaggca    480 
               
               
                   
               
               
                 cacccccacc tcttccctag ttattgggct gggagttgct gtcagactcc aatatccaga    540 
               
               
                   
               
               
                 ggaattacct tgattcttcc tcttaaaacc taagatgcca ggactaccct gttccccacg    600 
               
               
                   
               
               
                 tccccatgcc tgcctggccc tgcagtaatg tagtggcttc catctgttga gtcctgctgt    660 
               
               
                   
               
               
                 gagtagacgt cccatgaggc catttaattc tttctacatt cactccttgc gcagtgggtg    720 
               
               
                   
               
               
                 ttagcatcct tattttgcag atgagaaagc tgaggcctgg agaagctaaa tgatgtgccc    780 
               
               
                   
               
               
                 ggagttctag agctggtagg tgttagctgc cgacctaccc gccccttcta cacaccttgc    840 
               
               
                   
               
               
                 cacctgttgg accttccatc aaggccttgg gtccaatgtt acccactcat cacagtcaaa    900 
               
               
                   
               
               
                 aaacttcctc ctccagccag aattaacccg tccttccttc attgtctgac tgctgtttgt    960 
               
               
                   
               
               
                 catttatctc tcatgaaaga gtcaggtgtt ccagatgctt gcgttcattt ttcccttccc   1020 
               
               
                   
               
               
                 catgaaactg tgggcttctt ggaagcagga tatgtcatga acgcatctct gacttgctga   1080 
               
               
                   
               
               
                 tagaggatag agcaaaggat agaaagaaca cagcaccctg gcaggatgaa tctgcccctc   1140 
               
               
                   
               
               
                 tccagtcaag gtggggcttc ttgggaaagt tcttgaagca gattttcagt acagcaactc   1200 
               
               
                   
               
               
                 agagtggctc tcaatttttg agactcagtt ccccctttta aaatggggga atgacccctg   1260 
               
               
                   
               
               
                 tctggccaat tgttaggggc agatgggatg aagtatgtag aattagcctg aaaactggaa   1320 
               
               
                   
               
               
                 tggctgtacc tgtgtttggc tggtggttgg ttggtttatc catatttatc ggatgcccgc   1380 
               
               
                   
               
               
                 tgtgctccca gtgttgggtt ctgccctggg acaccatgga gaaccaacag atggagccct   1440 
               
               
                   
               
               
                 tgcctcctcg gagctcgcag cctggagggt cggtgtttgc aggttccccc ttcaggctgg   1500 
               
               
                   
               
               
                 ccgggtttcc aggcctctgt gcggcatcag caccttatca tttgctgtct gtcctaggca   1560 
               
               
                   
               
               
                 gactccagtt ctccagccag tctcagcctc atgacctcag acaatctcac ccagccttgg   1620 
               
               
                   
               
               
                 tctgctgagt cacagaatgg aaactggtgc tcactcccct ggccagggta gcatgagaat   1680 
               
               
                   
               
               
                 cagtgaggta gggtggaaaa gggctctcta ggtggctaac aattgggaac tctaggacag   1740 
               
               
                   
               
               
                 gtcagaactt gagtttgcag accagccctc tacaggacac tggtggacac agagtgttaa   1800 
               
               
                   
               
               
                 atcctgggct tgaggactgc tttgggcagc ccttttcttg tacctgttgc cgattctggt   1860 
               
               
                   
               
               
                 ggcttaagct ttcttcttgg agtgaatacc tactcattgt ctcaggcaat acaggccaac   1920 
               
               
                   
               
               
                 aactttcctc tttcagcaag tctgcagggt gtctcctgtc ccagcttcat acctctccct   1980 
               
               
                   
               
               
                 ccccactctt cccattccca ctctctccat ggctctggct gctatgcact cagaatacgg   2040 
               
               
                   
               
               
                 aagagctatt tgctggggtg gggtagagaa aactaaattc ccattgcttg atgttggctg   2100 
               
               
                   
               
               
                 agcaggtggc actgttggag actcgcctcc tattcctctt tctcctcctc attttttttc   2160 
               
               
                   
               
               
                 attatcctac agtgatcaat tgagcattgt taggtactgg accaatcatc tttttaaaaa   2220 
               
               
                   
               
               
                 tgaatcatct taacagccat gcacctgtag tcccagctag tggtgaggct gagacaggag   2280 
               
               
                   
               
               
                 gattgcttga agccaggagg attgcttgaa gccaggagtt caagaccagc ctgggtaaca   2340 
               
               
                   
               
               
                 tagtgatact ctgtctttac ttttaaaatt taaaaattag ctaggttgat ggtgtgcacc   2400 
               
               
                   
               
               
                 tgtagtctca gctactaggg aggctgaggg ggaggatcgc ttgggcccgg gagttcaagg   2460 
               
               
                   
               
               
                 atgcagtgaa ctgtagtcaa gccactgtac tccagcctgg gtgacagagc aagattccgt   2520 
               
               
                   
               
               
                 ctcaaaaaaa aaaaaaaa                                                 2538 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 174 
               
               
                 &lt;211&gt; LENGTH: 125 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 174 
               
               
                   
               
               
                 Met Thr Pro Val Trp Pro Ile Val Arg Gly Arg Trp Asp Glu Val Cys 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Arg Ile Ser Leu Lys Thr Gly Met Ala Val Pro Val Phe Gly Trp Trp 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Val Gly Leu Ser Ile Phe Ile Gly Cys Pro Leu Cys Ser Gln Cys 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Trp Val Leu Pro Trp Asp Thr Met Glu Asn Gln Gln Met Glu Pro Leu 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Pro Pro Arg Ser Ser Gln Pro Gly Gly Ser Val Phe Ala Gly Ser Pro 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Phe Arg Leu Ala Gly Phe Pro Gly Leu Cys Ala Ala Ser Ala Pro Tyr 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 His Leu Leu Ser Val Leu Gly Arg Leu Gln Phe Ser Ser Gln Ser Gln 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Pro His Asp Leu Arg Gln Ser His Pro Ala Leu Val Cys 
               
               
                         115                 120                 125 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 175 
               
               
                 &lt;211&gt; LENGTH: 2371 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (285) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 175 
               
               
                   
               
               
                 tgacttccag gtgaagggat gggaaaagtg gactctcatt gtagtgactc ccaacctacc     60 
               
               
                   
               
               
                 taataatttg ttaacttagg aatatgctat cattgttgac ttgttcttcc ttaggagaag    120 
               
               
                   
               
               
                 gacgattttc acccaccctt tctgttctat ggtggactct taacaggtgc tatgtgacca    180 
               
               
                   
               
               
                 ggaatctagc cgggagtagc agaggccctg tcttctgaag tctcaggctt agaagttacc    240 
               
               
                   
               
               
                 aaagtgggct cagaaactgt catctcctgg ttccaagttc gggcnctggc agcccagccg    300 
               
               
                   
               
               
                 ctatcttagc tgtctttccc agcggtgcta agagtggtct cagtgagaag gtagatgcca    360 
               
               
                   
               
               
                 actggagggc cagacctgtg tcctgtccca tgtcctcctt ggtggacgtt tctgtttact    420 
               
               
                   
               
               
                 cagagctgct agagaccatc ctgcccatcc gagttctgag attgggactg tgatgttggg    480 
               
               
                   
               
               
                 acctgaggac tggatggtag aatactgggg tcccccagct cttagcagga tgcaggctat    540 
               
               
                   
               
               
                 tgcttccaca cccctggccg tgagaacgtg gtatgtagga gagttggctg tagctttagg    600 
               
               
                   
               
               
                 atttctggaa gccaatttgg catggcctat ttgatctctg gcttgtgctc ctgctacact    660 
               
               
                   
               
               
                 gacagactga ttgcgtggct ctttcagaag acccaggaag ggcagctcca gccagaggac    720 
               
               
                   
               
               
                 cttcctggct atgcaggtgc acagctctta ggcatcaagc aaagggtcag ccagtcagta    780 
               
               
                   
               
               
                 gtagtgggag gaagcccttc ctcctcttat gcaagcagct cgcagccagc ccagaatctc    840 
               
               
                   
               
               
                 ttatgcagcc caaagggctt cttgaggtag agagccctcc ccagtgtctt cccaggataa    900 
               
               
                   
               
               
                 gtagaaatat gatcacagag caacggagca aaagctttcg ggagtgtgag gctgcatctg    960 
               
               
                   
               
               
                 ctggagcaaa aggaaaccgt gggcttttcc ggccagatac tcttgagctc tgtgaccctg   1020 
               
               
                   
               
               
                 ctcctgtcac cccaatttct ccaagccaga ggtagctttc tcagagcccc ttggtggttc   1080 
               
               
                   
               
               
                 tgtcctccaa atgctgctgt tgggagcggg cttccagctc tcagtggcag tgcacctcct   1140 
               
               
                   
               
               
                 cctaaatgca ggcacttgct aggaagagtg tgagctggcg tcttctgttc accctgccta   1200 
               
               
                   
               
               
                 gcagttgtca ccattcacaa gtggcattat ttatgttgtg ctgctgtcca gctgctaaga   1260 
               
               
                   
               
               
                 tcccttcatc tgcacaagcc ctggctagat atgtgtgaat gtgtggcatc atttcacttc   1320 
               
               
                   
               
               
                 agccgcccaa ttccatctct cctctgcagc cagattcact ggctgatgct cactgctcac   1380 
               
               
                   
               
               
                 tgtctatccc cacgaaattt agttttatca gtagtcttaa agtgttgatc tcaaacaagt   1440 
               
               
                   
               
               
                 acattagaaa aatcatgttt cttctctctc atcttacttt ttcttctcag atttctccct   1500 
               
               
                   
               
               
                 tcctagaaca ttctctctgt ttagcactaa tgttcacctc gtattttttg gaagtgcaaa   1560 
               
               
                   
               
               
                 aatctcaatt tgtgtctgtt tacagctctc tctcctcact gctcacagca aggggttctg   1620 
               
               
                   
               
               
                 tatcagtgga tttcattttg tagctgttga gatgttaagg caagcctcag catctgcccc   1680 
               
               
                   
               
               
                 tgctgggtgc acaatgctgc ttcctcgaag agaagacaca gagtccaagt ggcaggactt   1740 
               
               
                   
               
               
                 gaggttggct tcccactctg ccttagaagt taattttcca aagtacatta caaatctctg   1800 
               
               
                   
               
               
                 aggccattag gggaaaagga aggggtgtgg tttgtctttg aaattacagt taatactttt   1860 
               
               
                   
               
               
                 agacagtaag tccggctggt tgcagggcta tttgccccga cagcatcagc ctgtaacatt   1920 
               
               
                   
               
               
                 tcttctcttt cctttgtgcc actgagtcgt tccctggcca gaggacataa atggtgctgg   1980 
               
               
                   
               
               
                 taggaggtta tcagagtaag gaaggtagca gatataggtg cagggtgcct gtcattcact   2040 
               
               
                   
               
               
                 gtgttatttg gtttaaatca aagtgattct gggggaagct atgctctttc agtggataat   2100 
               
               
                   
               
               
                 aaaattggta actctattgt aaaacatgtc aatggtgtgt gaagaaaaat caaccaatct   2160 
               
               
                   
               
               
                 gtaggtgttg ataactagac agtactgtgt atgttacgtg cctgtgtgga tgtgcacttc   2220 
               
               
                   
               
               
                 cagcatggta tgtgtagcga tgtggatcat gccagagttc gtagatcctg ttttggggtt   2280 
               
               
                   
               
               
                 tgcacatgga tcgtatgtta agctttttct tttcaataaa tgaattttat ttttattttc   2340 
               
               
                   
               
               
                 gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                  2371 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 176 
               
               
                 &lt;211&gt; LENGTH: 114 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 176 
               
               
                   
               
               
                 Met Cys Gly Ile Ile Ser Leu Gln Pro Pro Asn Ser Ile Ser Pro Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Gln Pro Asp Ser Leu Ala Asp Ala His Cys Ser Leu Ser Ile Pro Thr 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Lys Phe Ser Phe Ile Ser Ser Leu Lys Val Leu Ile Ser Asn Lys Tyr 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ile Arg Lys Ile Met Phe Leu Leu Ser His Leu Thr Phe Ser Ser Gln 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ile Ser Pro Phe Leu Glu His Ser Leu Cys Leu Ala Leu Met Phe Thr 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ser Tyr Phe Leu Glu Val Gln Lys Ser Gln Phe Val Ser Val Tyr Ser 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ser Leu Ser Ser Leu Leu Thr Ala Arg Gly Ser Val Ser Val Asp Phe 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ile Leu 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 177 
               
               
                 &lt;211&gt; LENGTH: 1665 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1633) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 177 
               
               
                   
               
               
                 atggcagcgc ccagcaacaa gacagagctg gcctggagtc cgcggctggc cgcgtgagta     60 
               
               
                   
               
               
                 ggtgattgtc tgacaagcag aggcatgagc tgggtccagg ccaccctact ggcccgaggc    120 
               
               
                   
               
               
                 ctctgtaggg cctggggagg cacctgcggg gccgccctca caggaacctc catctctcag    180 
               
               
                   
               
               
                 gtccctcgcc ggctccctcg gggcctccac tgcagcgcag ctgcccatag ctctgaacag    240 
               
               
                   
               
               
                 tccctggttc ccagcccacc ggaaccccgg cagaggccca ccaaggctct ggtgcccttt    300 
               
               
                   
               
               
                 gaggacctgt ttgggcaggc gcctggtggg gaacgggaca aggcgagctt cctgcagacg    360 
               
               
                   
               
               
                 gtgcagaaat ttgcggagca cagcgtgcgt aagcggggcc acattgactt catctacctg    420 
               
               
                   
               
               
                 gccctgcgca agatgcggga gtatggtgtc gagcgggacc tggctgtgta caaccagctg    480 
               
               
                   
               
               
                 ctcaacatct tccccaagga ggtcttccgg cctcgcaaca tcatccagcg catcttcgtc    540 
               
               
                   
               
               
                 cactaccctc ggcagcagga gtgtgggatt gctgtcctgg agcagatgga gaaccacggt    600 
               
               
                   
               
               
                 gtgatgccca acaaggagac ggagttcctg ctgattcaga tctttggacg caaaagctac    660 
               
               
                   
               
               
                 cccatgctca agttggtgcg cctgaagctg tggttccctc gattcatgaa cgtcaacccc    720 
               
               
                   
               
               
                 ttcccagtgc cccgggacct gccccaggac cctgtggagc tggccatgtt tggcctgcgg    780 
               
               
                   
               
               
                 cacatggagc ctgaccttag tgccagggtc accatctacc aggttccttt gcccaaagac    840 
               
               
                   
               
               
                 tcaacaggtg cagcagatcc cccccagccc cacatcgtag gaatccagag tcccgatcag    900 
               
               
                   
               
               
                 caggccgccc tggcccggca caatccagcc cggcctgtct ttgttgaggg ccccttctcc    960 
               
               
                   
               
               
                 ctgtggctcc gcaacaagtg tgtgtattac cacatcctca gagctgactt gctgcccccg   1020 
               
               
                   
               
               
                 gaggagaggg aagtggaaga gacgccggag gagtggaacc tctactaccc gatgcagctg   1080 
               
               
                   
               
               
                 gacctggagt atgtgaggag tggctgggac aactacgagt ttgacatcaa tgaagtggag   1140 
               
               
                   
               
               
                 gaaggccctg tcttcgccat gtgcatggcg ggtgctcatg accaggcgac gatggctaag   1200 
               
               
                   
               
               
                 tggatccagg gcctgcagga gaccaaccca accctggccc agatccccgt ggtcttccgc   1260 
               
               
                   
               
               
                 ctcgccgggt ccacccggga gctccagaca tcctctgcag ggctggagga gccgcccctg   1320 
               
               
                   
               
               
                 cccgaggacc accaggaaga agacgacaac ctgcagcgac agcagcaggg ccagagctag   1380 
               
               
                   
               
               
                 tctgagccgg cgcgagggca cgggctgtgg cccgaggagg cggtggactg aaggcatgag   1440 
               
               
                   
               
               
                 atgccctttg agtgtacagc aaatcaatgt tttcctgctt ggggctctct tccctcatct   1500 
               
               
                   
               
               
                 ctagcagtat ggcatcccct ccccaggatc tcgggctgcc agcgatgggc aggcgagacc   1560 
               
               
                   
               
               
                 cctccagaat ctgcaggcgc ctctggttct ccgaattcaa ataaataggt gcgggagcgc   1620 
               
               
                   
               
               
                 tgttggttgt gcncgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                   1665 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 178 
               
               
                 &lt;211&gt; LENGTH: 431 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 178 
               
               
                   
               
               
                 Met Ser Trp Val Gln Ala Thr Leu Leu Ala Arg Gly Leu Cys Arg Ala 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Trp Gly Gly Thr Cys Gly Ala Ala Leu Thr Gly Thr Ser Ile Ser Gln 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Val Pro Arg Arg Leu Pro Arg Gly Leu His Cys Ser Ala Ala Ala His 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ser Ser Glu Gln Ser Leu Val Pro Ser Pro Pro Glu Pro Arg Gln Arg 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Pro Thr Lys Ala Leu Val Pro Phe Glu Asp Leu Phe Gly Gln Ala Pro 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly Gly Glu Arg Asp Lys Ala Ser Phe Leu Gln Thr Val Gln Lys Phe 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ala Glu His Ser Val Arg Lys Arg Gly His Ile Asp Phe Ile Tyr Leu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ala Leu Arg Lys Met Arg Glu Tyr Gly Val Glu Arg Asp Leu Ala Val 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Tyr Asn Gln Leu Leu Asn Ile Phe Pro Lys Glu Val Phe Arg Pro Arg 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Asn Ile Ile Gln Arg Ile Phe Val His Tyr Pro Arg Gln Gln Glu Cys 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Gly Ile Ala Val Leu Glu Gln Met Glu Asn His Gly Val Met Pro Asn 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Lys Glu Thr Glu Phe Leu Leu Ile Gln Ile Phe Gly Arg Lys Ser Tyr 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Pro Met Leu Lys Leu Val Arg Leu Lys Leu Trp Phe Pro Arg Phe Met 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Asn Val Asn Pro Phe Pro Val Pro Arg Asp Leu Pro Gln Asp Pro Val 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Glu Leu Ala Met Phe Gly Leu Arg His Met Glu Pro Asp Leu Ser Ala 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Arg Val Thr Ile Tyr Gln Val Pro Leu Pro Lys Asp Ser Thr Gly Ala 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Ala Asp Pro Pro Gln Pro His Ile Val Gly Ile Gln Ser Pro Asp Gln 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Gln Ala Ala Leu Ala Arg His Asn Pro Ala Arg Pro Val Phe Val Glu 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Gly Pro Phe Ser Leu Trp Leu Arg Asn Lys Cys Val Tyr Tyr His Ile 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Leu Arg Ala Asp Leu Leu Pro Pro Glu Glu Arg Glu Val Glu Glu Thr 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Pro Glu Glu Trp Asn Leu Tyr Tyr Pro Met Gln Leu Asp Leu Glu Tyr 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Val Arg Ser Gly Trp Asp Asn Tyr Glu Phe Asp Ile Asn Glu Val Glu 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Glu Gly Pro Val Phe Ala Met Cys Met Ala Gly Ala His Asp Gln Ala 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 Thr Met Ala Lys Trp Ile Gln Gly Leu Gln Glu Thr Asn Pro Thr Leu 
               
               
                     370                 375                 380 
               
               
                   
               
               
                 Ala Gln Ile Pro Val Val Phe Arg Leu Ala Gly Ser Thr Arg Glu Leu 
               
               
                 385                 390                 395                 400 
               
               
                   
               
               
                 Gln Thr Ser Ser Ala Gly Leu Glu Glu Pro Pro Leu Pro Glu Asp His 
               
               
                                 405                 410                 415 
               
               
                   
               
               
                 Gln Glu Glu Asp Asp Asn Leu Gln Arg Gln Gln Gln Gly Gln Ser 
               
               
                             420                 425                 430 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 179 
               
               
                 &lt;211&gt; LENGTH: 2080 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 179 
               
               
                   
               
               
                 ctccggccgg cgtccagttt gagtctaggt tggagttgga accgtggaga tgcggaagga     60 
               
               
                   
               
               
                 aaccccaccc cccctagtgc ccccggcggc ccgggagtgg aatcttcccc caaatgcgcc    120 
               
               
                   
               
               
                 cgcctgcatg gaacggcagt tggaggctgc gcggtaccgg tccgatgggg cgcttctcct    180 
               
               
                   
               
               
                 cggggcctcc agcctgagtg ggcgctgctg ggccggctcc ctctggcttt ttaaggaccc    240 
               
               
                   
               
               
                 ctgtgccgcc cccaacgaag gcttctgctc cgccggagtc caaacggagg ctggagtggc    300 
               
               
                   
               
               
                 tgacctcact tgggttgggg agagaggtat tctagtggcc tccgattcag gtgctgttga    360 
               
               
                   
               
               
                 attgtgggaa ctagatgaga atgagacact tattgtcagc aagttctgca agtatgagca    420 
               
               
                   
               
               
                 tgatgacatt gtgtctacag tcagtgtctt gagctctggc acacaagctg tcagtggtag    480 
               
               
                   
               
               
                 caaagacatc tgcatcaagg tttgggacct tgctcagcag gtggtactga gttcataccg    540 
               
               
                   
               
               
                 agctcatgct gctcaggtca cttgtgttgc tgcctctcct cacaaggact ctgtgtttct    600 
               
               
                   
               
               
                 ttcatgcagc gaggacaata gaattttact ctgggatacc cgctgtccca agccagcatc    660 
               
               
                   
               
               
                 acagattggc tgcagtgcgc ctggctacct tcctacctcg ctggcttggc atcctcagca    720 
               
               
                   
               
               
                 aagtgaagtc tttgtctttg gtgatgagaa tgggacagtc tcccttgtgg acaccaagag    780 
               
               
                   
               
               
                 tacaagctgt gtcctgagct cagctgtaca ctcccagtgt gtcactgggc tggtgttctc    840 
               
               
                   
               
               
                 cccacacagt gttcccttcc tggcctctct cagtgaagac tgctcacttg ctgtgctgga    900 
               
               
                   
               
               
                 ctcaagcctt tctgagttgt ttagaagcca agcccacaga gactttgtga gagatgcgac    960 
               
               
                   
               
               
                 ttggtccccg ctcaatcact ccctgcttac cacagtgggc tgggaccatc aggtcgtcca   1020 
               
               
                   
               
               
                 ccacgttgtg cccacagaac ctctcccagc ccctggacct gcaagtgtta ctgagtagat   1080 
               
               
                   
               
               
                 tggatttaag acaaaaagca agtcccccat gagtgtccac ttctttgccc tgccctctca   1140 
               
               
                   
               
               
                 gcttgtgaga caacacagga gccttctata gtatgttgat atgctagatc tgtgccgtta   1200 
               
               
                   
               
               
                 ataggcatcg tctctcagcc tgagggaggc tggattctgg gttcctgtag tcacagggag   1260 
               
               
                   
               
               
                 gaaaagcttt cttaaaaatg gacatgtatg tgcgtgtgag tgtgtgtgta gatttatagt   1320 
               
               
                   
               
               
                 ttttggtagt ggcaggaata aaaaaaatcc atcctacatc ttccctaagc actgcctctc   1380 
               
               
                   
               
               
                 tctcaccccc caaaacaagt tgacgaaagg gttttatgta gctgtctatg aggaattggc   1440 
               
               
                   
               
               
                 cgtgtctggg tgggttatgg gatgtgggca tccctgggtt cttggaagca gctcttatgc   1500 
               
               
                   
               
               
                 tactcataga gatgggattg actttatttt tttatagtgc ttaattcacc attatgagaa   1560 
               
               
                   
               
               
                 atgcttccag tcacaaaaat gcagcccagc tcactctgag gaagaagcag gacttggtac   1620 
               
               
                   
               
               
                 ggttttacac aactccttac cattaaactg aatcagaaat ccattttctg gctgaataaa   1680 
               
               
                   
               
               
                 aagtttggct tgcctgtgta atgcccactc ccttccccct ggctccctag tgatgggaca   1740 
               
               
                   
               
               
                 tatatgagac agaagtgttt ttctatcata gacaccatag gggaaagttt ggggatgaag   1800 
               
               
                   
               
               
                 gagagcttaa aggtgtttca attaagttag aaaactgaca caggctgttg agaattcttt   1860 
               
               
                   
               
               
                 gccacttttc ccaccccaaa acagcatggg gcctgacatc ttctgccctg gtcccctttc   1920 
               
               
                   
               
               
                 tcttgatgtg gaaagtctga atgcagtatt tatagacttc taaggtttta aaatccagta   1980 
               
               
                   
               
               
                 ttcaagaaga aaatcagaaa tactggttgg tgaaataaag agtttaggca ttgttggcct   2040 
               
               
                   
               
               
                 gtcttttttg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                         2080 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 180 
               
               
                 &lt;211&gt; LENGTH: 342 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 180 
               
               
                   
               
               
                 Met Arg Lys Glu Thr Pro Pro Pro Leu Val Pro Pro Ala Ala Arg Glu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Trp Asn Leu Pro Pro Asn Ala Pro Ala Cys Met Glu Arg Gln Leu Glu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ala Ala Arg Tyr Arg Ser Asp Gly Ala Leu Leu Leu Gly Ala Ser Ser 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Ser Gly Arg Cys Trp Ala Gly Ser Leu Trp Leu Phe Lys Asp Pro 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Cys Ala Ala Pro Asn Glu Gly Phe Cys Ser Ala Gly Val Gln Thr Glu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ala Gly Val Ala Asp Leu Thr Trp Val Gly Glu Arg Gly Ile Leu Val 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ala Ser Asp Ser Gly Ala Val Glu Leu Trp Glu Leu Asp Glu Asn Glu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Thr Leu Ile Val Ser Lys Phe Cys Lys Tyr Glu His Asp Asp Ile Val 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Ser Thr Val Ser Val Leu Ser Ser Gly Thr Gln Ala Val Ser Gly Ser 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Lys Asp Ile Cys Ile Lys Val Trp Asp Leu Ala Gln Gln Val Val Leu 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Ser Ser Tyr Arg Ala His Ala Ala Gln Val Thr Cys Val Ala Ala Ser 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Pro His Lys Asp Ser Val Phe Leu Ser Cys Ser Glu Asp Asn Arg Ile 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Leu Leu Trp Asp Thr Arg Cys Pro Lys Pro Ala Ser Gln Ile Gly Cys 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Ser Ala Pro Gly Tyr Leu Pro Thr Ser Leu Ala Trp His Pro Gln Gln 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Ser Glu Val Phe Val Phe Gly Asp Glu Asn Gly Thr Val Ser Leu Val 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Asp Thr Lys Ser Thr Ser Cys Val Leu Ser Ser Ala Val His Ser Gln 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Cys Val Thr Gly Leu Val Phe Ser Pro His Ser Val Pro Phe Leu Ala 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Ser Leu Ser Glu Asp Cys Ser Leu Ala Val Leu Asp Ser Ser Leu Ser 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Glu Leu Phe Arg Ser Gln Ala His Arg Asp Phe Val Arg Asp Ala Thr 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Trp Ser Pro Leu Asn His Ser Leu Leu Thr Thr Val Gly Trp Asp His 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Gln Val Val His His Val Val Pro Thr Glu Pro Leu Pro Ala Pro Gly 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Pro Ala Ser Val Thr Glu 
               
               
                             340 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 181 
               
               
                 &lt;211&gt; LENGTH: 1313 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (1165) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 181 
               
               
                   
               
               
                 tgcttaagca cgaagcttct tttcctgttt agtcctagtg gttagtgtcg aaagaggaat     60 
               
               
                   
               
               
                 catcgaggtt tcttgatgaa acctagtgcg gtccaacctc tgcctttttt tctgttgtct    120 
               
               
                   
               
               
                 tttttcctac tccgggctgt tggcggtgtc agcaccgctg ctgggggcgg gggtggaggg    180 
               
               
                   
               
               
                 gagaaagagt cgggttaccg aagtgcgtca ttcctggctc tagcagggcc tgctcgggag    240 
               
               
                   
               
               
                 ctgctggtgt ttgttactgt cctcgcagca cttttctgcc aaccttctct ctctgcgtat    300 
               
               
                   
               
               
                 tggttaggag caaaagcagg aggcggtctc ctaattctgt ctgtagccta gcgcgttgcg    360 
               
               
                   
               
               
                 tttaagggta tatctgaact tattttgtta aaaaaaaggc tctgggaagt ggatgcattt    420 
               
               
                   
               
               
                 gtttaatgac atataattca ggtagtttag gcttgctctc atatactttc cgatgaacag    480 
               
               
                   
               
               
                 tggggttaat tttcaacatt ttcaaccact taacgttaaa atgcctggtt ttctttctac    540 
               
               
                   
               
               
                 attgatatca atctataatt agggatcaga aggaccagtt taaggtatat aagtgttcag    600 
               
               
                   
               
               
                 cagtttttca agtggttgaa ttgcagtttt atgacacatt atgttaaata gtcgattttt    660 
               
               
                   
               
               
                 tttttttcat tttgaactaa ggtgccacgt taagtaagtt aattgcagat gtttaagttc    720 
               
               
                   
               
               
                 gttttcatca catttcccta tttgtctttt taggtataat tttaaatatg ccctttgggt    780 
               
               
                   
               
               
                 ttatggactt cattaaaatt cttaaagatg gttatatctt tgtgtttaac tgaattctta    840 
               
               
                   
               
               
                 aatttatcac ctaccaaaga attgtgtaag gcgtaaggcg gctgtatagt tacattgttg    900 
               
               
                   
               
               
                 gattttgact taacatgcta gtttttgata cttttgctat ctttgggtag aagtgtactt    960 
               
               
                   
               
               
                 agagaacata gtatcttcct cttaattctt tttgaagata ataatgagag gagggagtgg   1020 
               
               
                   
               
               
                 gtaggaggta ggtgtgaagc agaagtggcc ttgagttgat tattgtagct ggatgaatac   1080 
               
               
                   
               
               
                 agaagcgctc attgttacta ttattctctc tacttttgtg cgtgctgtta aacatttcca   1140 
               
               
                   
               
               
                 tagtttaaga taaacttttt ttgcnagtag aatttccaga ttgtcttaca gtcttggggg   1200 
               
               
                   
               
               
                 taatgactta agtttatatt tacatgtcaa aattacttgc ataggaaatt tagccttgtg   1260 
               
               
                   
               
               
                 taagtgatta cacaatgctt ggcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa          1313 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 182 
               
               
                 &lt;211&gt; LENGTH: 91 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 182 
               
               
                   
               
               
                 Met Lys Pro Ser Ala Val Gln Pro Leu Pro Phe Phe Leu Leu Ser Phe 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Phe Leu Leu Arg Ala Val Gly Gly Val Ser Thr Ala Ala Gly Gly Gly 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gly Gly Gly Glu Lys Glu Ser Gly Tyr Arg Ser Ala Ser Phe Leu Ala 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Ala Gly Pro Ala Arg Glu Leu Leu Val Phe Val Thr Val Leu Ala 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ala Leu Phe Cys Gln Pro Ser Leu Ser Ala Tyr Trp Leu Gly Ala Lys 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ala Gly Gly Gly Leu Leu Ile Leu Ser Val Ala 
               
               
                                  85                  90 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 183 
               
               
                 &lt;211&gt; LENGTH: 1484 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 183 
               
               
                   
               
               
                 gttttcatct ctaaaagttg gatttgggtg tgtgtttcat gtcttccatt tatatatgtt     60 
               
               
                   
               
               
                 tttaatgaac atgcgtaata taataactac attcatgtct ttgctaattc taacatatgt    120 
               
               
                   
               
               
                 gccaattctg gttggttgat taataaatct cttcattatg ggtatttcct aatatattac    180 
               
               
                   
               
               
                 ctgtgttata attttacatt ttatgtcaga cattgtgaat ttttaccttg ttgggtgctg    240 
               
               
                   
               
               
                 tatatttttg tattcctgta agtgttacac tttgttctgt cacacaatta agctagtcgg    300 
               
               
                   
               
               
                 aaacaatttt atctttttaa gatatggtag atgggtttgg agcagtgctc agcctagaac    360 
               
               
                   
               
               
                 tgatttactt ttgacttcta aggcaaggcc cttttatgca gtgtatccac tgctctatgt    420 
               
               
                   
               
               
                 atcatgcagc tttttcagtc tggctgaggg aacaggcgtg ggtgctggcc cttttgtgca    480 
               
               
                   
               
               
                 tcaggccttt gttatcacag aactttcatt tggttctttt cctggcttcc tgtcatttct    540 
               
               
                   
               
               
                 tcacacgtgt gggttgatca gtattcacca gaatacctga ggagaccagc ccaggcaaca    600 
               
               
                   
               
               
                 tagtgagacc ccctttctcc ccattaaaac agacacaccc acacacccac ccacccacac    660 
               
               
                   
               
               
                 cccttgccca aagtcatagt ttttaggtgg tatagatgtg atttgaactt agatcccggc    720 
               
               
                   
               
               
                 tttgataaac cagtgttttt taaagcactt tatgttgcct gccctgtaca gcgtctttcc    780 
               
               
                   
               
               
                 tcttcctttt gatgagataa aatactgaaa gcataactct gaattacagt ataaaaatac    840 
               
               
                   
               
               
                 acattttggc ttattagggc agtgggatgt ctctgccctc ttcccccaca tttcttttat    900 
               
               
                   
               
               
                 gttcatgcag aaaataaaat ggaaatcctt tttctttttg caagaacatg aattataagc    960 
               
               
                   
               
               
                 ttataggaat catttatcat ccatgtttaa aaaattccca tctctcagct aaaagactac   1020 
               
               
                   
               
               
                 atcatatgac ttaattctaa taggtcaact ctactgaagt taagagcatt cccaaagaat   1080 
               
               
                   
               
               
                 gctctatata aaacttgtgt gtatgtttgc aggaatctta atggatatgt ttctagagga   1140 
               
               
                   
               
               
                 aatgctccca tgagcattct ctccatcatt tagcagctgt taaaatgatg ctcttcccaa   1200 
               
               
                   
               
               
                 tgcccttgtt ccctcattgt aaacgtgctc tgagttaacc tggtagccag tacacagtac   1260 
               
               
                   
               
               
                 acagtaaatg acatttctta tctgtatgtt agaactacta ttcaataagc taaaatattc   1320 
               
               
                   
               
               
                 tgagcttcct cagattttct cctttttttt tttttgggac ggagtcttgc cctgttgccc   1380 
               
               
                   
               
               
                 aggctggagt gcagtgagct gagatcacgc cactacactc catcctgggt ggtggagtga   1440 
               
               
                   
               
               
                 gaccctgtct aagcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                    1484 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 184 
               
               
                 &lt;211&gt; LENGTH: 125 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 184 
               
               
                   
               
               
                 Met Ser Asp Ile Val Asn Phe Tyr Leu Val Gly Cys Cys Ile Phe Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Tyr Ser Cys Lys Cys Tyr Thr Leu Phe Cys His Thr Ile Lys Leu Val 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gly Asn Asn Phe Ile Phe Leu Arg Tyr Gly Arg Trp Val Trp Ser Ser 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ala Gln Pro Arg Thr Asp Leu Leu Leu Thr Ser Lys Ala Arg Pro Phe 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Tyr Ala Val Tyr Pro Leu Leu Tyr Val Ser Cys Ser Phe Phe Ser Leu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ala Glu Gly Thr Gly Val Gly Ala Gly Pro Phe Val His Gln Ala Phe 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Val Ile Thr Glu Leu Ser Phe Gly Ser Phe Pro Gly Phe Leu Ser Phe 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Leu His Thr Cys Gly Leu Ile Ser Ile His Gln Asn Thr 
               
               
                         115                 120                 125 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 185 
               
               
                 &lt;211&gt; LENGTH: 2520 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 185 
               
               
                   
               
               
                 cccgagtgca tctggaatac gcagagtcag taagaccatg gctacgtcct cgatgtctaa     60 
               
               
                   
               
               
                 gggttgcttt gtttttaagc caaactccaa aaagagaaag atctctctgc caatagagga    120 
               
               
                   
               
               
                 ctattttaac aaagggaaaa atgagcctga ggacagtaag cttcgattcg aaacttatca    180 
               
               
                   
               
               
                 gttgatatgg cagcagatga aatctgaaaa tgagcgacta caagaggaat taaataaaaa    240 
               
               
                   
               
               
                 cttgtttgac aatctgattg aatttctgca aaaatcacat tctggattcc agaagaattc    300 
               
               
                   
               
               
                 aagagacttg ggcggtcaaa taaaactcag agaaattcca actgctgctc ttgttcttgg    360 
               
               
                   
               
               
                 tgtgaatgtc acagatcatg atttgacatt cggaagtcta acagaggccc ttcagaataa    420 
               
               
                   
               
               
                 tgtcacacca tatgtagtct cattgcaagc taaagattgt ccagatatga aacatttttt    480 
               
               
                   
               
               
                 gcaaaagttg atctcacagt tgatggactg ctgtgtagat ataaaatcca aagaggagga    540 
               
               
                   
               
               
                 aagtgttcac gtcacccaaa gaaagacaca ttattcaatg gattcacttt ccagttggta    600 
               
               
                   
               
               
                 tatgactgtc acacagaaga cggacccaaa aatgctaagc aaaaaaagga ctacttctag    660 
               
               
                   
               
               
                 ccaatggcag tctcctcctg ttgtcgttat cttgaaggat atggaaagct ttgccacaaa    720 
               
               
                   
               
               
                 agtactacaa gacttcataa ttatcagcag tcaacatctc catgaatttc cactaatact    780 
               
               
                   
               
               
                 catttttgga atagccacat ctcctattat catccaccga ttgcttcctc atgcagtatc    840 
               
               
                   
               
               
                 atctctattg tgcatagaac tgttccaatc tttgtcttgt aaggagcacc tgactacggt    900 
               
               
                   
               
               
                 actcgataag ctacttctta caactcagtt tccctttaaa ataaatgaaa aagtattaca    960 
               
               
                   
               
               
                 ggttctgacc aacatctttt tgtatcatga tttctcagtt caaaacttta taaaaggact   1020 
               
               
                   
               
               
                 tcagctttct ctattagagc atttctattc ccagccctta agtgtcctgt gctgtaatct   1080 
               
               
                   
               
               
                 tccagaagcc aaaagaagaa taaatttttt atcaaataat caatgtgaaa acatccgacg   1140 
               
               
                   
               
               
                 tctaccatct tttaggaggt acgtggaaaa gcaagcttca gaaaagcaag ttgcgctctt   1200 
               
               
                   
               
               
                 gaccaatgag agatatttga aggaggaaac acaattatta ctagaaaacc tgcatgttta   1260 
               
               
                   
               
               
                 tcatatgaat tacttcctgg ttttgagatg tcttcataag ttcacctctt ctcttcccaa   1320 
               
               
                   
               
               
                 gtatccacta ggtcgacaga tcagagagtt gtactgtaca tgtttagaaa agaacatatg   1380 
               
               
                   
               
               
                 ggattcagag gagtatgcat cagtcttgca gctgctgagg atgttggcaa aggatgaact   1440 
               
               
                   
               
               
                 gatgaccata cttgagaaat gtttcaaggt ttttaagtct tattgtgaaa accaccttgg   1500 
               
               
                   
               
               
                 cagcacagct aagagaatag aggagttcct ggcccagttt cagagcctcg atgaaaccaa   1560 
               
               
                   
               
               
                 agaggaagaa gatgcttctg ggtcacagcc aaaggggctt cagaagacag acctctatca   1620 
               
               
                   
               
               
                 tcttcagaag tccttattgg aaatgaagga gttaagaaga agtaagaagc aaaccaaatt   1680 
               
               
                   
               
               
                 tgaagtactc agagaaaatg ttgtgaactt cattgactgt ctagtgagag aataccttct   1740 
               
               
                   
               
               
                 gcctcctgag acacagcctc tccatgaggt ggtgtacttc agtgctgccc atgcccttcg   1800 
               
               
                   
               
               
                 tgagcattta aatgctgctc cgcgaattgc cctccatact gcactcaaca atccttacta   1860 
               
               
                   
               
               
                 ttatctcaag aatgaagcac tgaaaagcga agaaggctgc attccgaata tcgccccaga   1920 
               
               
                   
               
               
                 catctgcata gcatacaaac tgcacctaga gtgtagcagg ctcatcaacc tcgtggactg   1980 
               
               
                   
               
               
                 gtcagaggct tttgcaacag ttgtgacagc tgctgaaaaa atggatgcaa attctgcaac   2040 
               
               
                   
               
               
                 ctcagaagaa atgaatgaaa ttatccatgc tcggtttatt agagctgttt ctgaactaga   2100 
               
               
                   
               
               
                 acttttagga tttataaaac ctaccaaaca gaagactgac catgtggcaa gactaacatg   2160 
               
               
                   
               
               
                 gggaggctgc tagaaagcaa ataagcaaag ccagaactat cacatttagc ttaagagaaa   2220 
               
               
                   
               
               
                 aaggtgacca gtcatattta catatattag aggagcctgt tttgttgaga agataaatgt   2280 
               
               
                   
               
               
                 gtaaccccca ttgatgttta accagaaaag tacattgcta accccaaaca ggcatgtatc   2340 
               
               
                   
               
               
                 aaaacacctg tggagtactt tagactccaa caaataataa tgtaactaaa actgctcaca   2400 
               
               
                   
               
               
                 cattttactg tactttccaa agtcattact aaattgtgag taaatcattc ttgaacttag   2460 
               
               
                   
               
               
                 agtatgtaaa tgtaataaat tccgttatcc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2520 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 186 
               
               
                 &lt;211&gt; LENGTH: 711 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 186 
               
               
                   
               
               
                 Met Ala Thr Ser Ser Met Ser Lys Gly Cys Phe Val Phe Lys Pro Asn 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ser Lys Lys Arg Lys Ile Ser Leu Pro Ile Glu Asp Tyr Phe Asn Lys 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gly Lys Asn Glu Pro Glu Asp Ser Lys Leu Arg Phe Glu Thr Tyr Gln 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Ile Trp Gln Gln Met Lys Ser Glu Asn Glu Arg Leu Gln Glu Glu 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Asn Lys Asn Leu Phe Asp Asn Leu Ile Glu Phe Leu Gln Lys Ser 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 His Ser Gly Phe Gln Lys Asn Ser Arg Asp Leu Gly Gly Gln Ile Lys 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Leu Arg Glu Ile Pro Thr Ala Ala Leu Val Leu Gly Val Asn Val Thr 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Asp His Asp Leu Thr Phe Gly Ser Leu Thr Glu Ala Leu Gln Asn Asn 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Val Thr Pro Tyr Val Val Ser Leu Gln Ala Lys Asp Cys Pro Asp Met 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Lys His Phe Leu Gln Lys Leu Ile Ser Gln Leu Met Asp Cys Cys Val 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Asp Ile Lys Ser Lys Glu Glu Glu Ser Val His Val Thr Gln Arg Lys 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Thr His Tyr Ser Met Asp Ser Leu Ser Ser Trp Tyr Met Thr Val Thr 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Gln Lys Thr Asp Pro Lys Met Leu Ser Lys Lys Arg Thr Thr Ser Ser 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Gln Trp Gln Ser Pro Pro Val Val Val Ile Leu Lys Asp Met Glu Ser 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Phe Ala Thr Lys Val Leu Gln Asp Phe Ile Ile Ile Ser Ser Gln His 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Leu His Glu Phe Pro Leu Ile Leu Ile Phe Gly Ile Ala Thr Ser Pro 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Ile Ile Ile His Arg Leu Leu Pro His Ala Val Ser Ser Leu Leu Cys 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Ile Glu Leu Phe Gln Ser Leu Ser Cys Lys Glu His Leu Thr Thr Val 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Leu Asp Lys Leu Leu Leu Thr Thr Gln Phe Pro Phe Lys Ile Asn Glu 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Lys Val Leu Gln Val Leu Thr Asn Ile Phe Leu Tyr His Asp Phe Ser 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Val Gln Asn Phe Ile Lys Gly Leu Gln Leu Ser Leu Leu Glu His Phe 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Tyr Ser Gln Pro Leu Ser Val Leu Cys Cys Asn Leu Pro Glu Ala Lys 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Arg Arg Ile Asn Phe Leu Ser Asn Asn Gln Cys Glu Asn Ile Arg Arg 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 Leu Pro Ser Phe Arg Arg Tyr Val Glu Lys Gln Ala Ser Glu Lys Gln 
               
               
                     370                 375                 380 
               
               
                   
               
               
                 Val Ala Leu Leu Thr Asn Glu Arg Tyr Leu Lys Glu Glu Thr Gln Leu 
               
               
                 385                 390                 395                 400 
               
               
                   
               
               
                 Leu Leu Glu Asn Leu His Val Tyr His Met Asn Tyr Phe Leu Val Leu 
               
               
                                 405                 410                 415 
               
               
                   
               
               
                 Arg Cys Leu His Lys Phe Thr Ser Ser Leu Pro Lys Tyr Pro Leu Gly 
               
               
                             420                 425                 430 
               
               
                   
               
               
                 Arg Gln Ile Arg Glu Leu Tyr Cys Thr Cys Leu Glu Lys Asn Ile Trp 
               
               
                         435                 440                 445 
               
               
                   
               
               
                 Asp Ser Glu Glu Tyr Ala Ser Val Leu Gln Leu Leu Arg Met Leu Ala 
               
               
                     450                 455                 460 
               
               
                   
               
               
                 Lys Asp Glu Leu Met Thr Ile Leu Glu Lys Cys Phe Lys Val Phe Lys 
               
               
                 465                 470                 475                 480 
               
               
                   
               
               
                 Ser Tyr Cys Glu Asn His Leu Gly Ser Thr Ala Lys Arg Ile Glu Glu 
               
               
                                 485                 490                 495 
               
               
                   
               
               
                 Phe Leu Ala Gln Phe Gln Ser Leu Asp Glu Thr Lys Glu Glu Glu Asp 
               
               
                             500                 505                 510 
               
               
                   
               
               
                 Ala Ser Gly Ser Gln Pro Lys Gly Leu Gln Lys Thr Asp Leu Tyr His 
               
               
                         515                 520                 525 
               
               
                   
               
               
                 Leu Gln Lys Ser Leu Leu Glu Met Lys Glu Leu Arg Arg Ser Lys Lys 
               
               
                     530                 535                 540 
               
               
                   
               
               
                 Gln Thr Lys Phe Glu Val Leu Arg Glu Asn Val Val Asn Phe Ile Asp 
               
               
                 545                 550                 555                 560 
               
               
                   
               
               
                 Cys Leu Val Arg Glu Tyr Leu Leu Pro Pro Glu Thr Gln Pro Leu His 
               
               
                                 565                 570                 575 
               
               
                   
               
               
                 Glu Val Val Tyr Phe Ser Ala Ala His Ala Leu Arg Glu His Leu Asn 
               
               
                             580                 585                 590 
               
               
                   
               
               
                 Ala Ala Pro Arg Ile Ala Leu His Thr Ala Leu Asn Asn Pro Tyr Tyr 
               
               
                         595                 600                 605 
               
               
                   
               
               
                 Tyr Leu Lys Asn Glu Ala Leu Lys Ser Glu Glu Gly Cys Ile Pro Asn 
               
               
                     610                 615                 620 
               
               
                   
               
               
                 Ile Ala Pro Asp Ile Cys Ile Ala Tyr Lys Leu His Leu Glu Cys Ser 
               
               
                 625                 630                 635                 640 
               
               
                   
               
               
                 Arg Leu Ile Asn Leu Val Asp Trp Ser Glu Ala Phe Ala Thr Val Val 
               
               
                                 645                 650                 655 
               
               
                   
               
               
                 Thr Ala Ala Glu Lys Met Asp Ala Asn Ser Ala Thr Ser Glu Glu Met 
               
               
                             660                 665                 670 
               
               
                   
               
               
                 Asn Glu Ile Ile His Ala Arg Phe Ile Arg Ala Val Ser Glu Leu Glu 
               
               
                         675                 680                 685 
               
               
                   
               
               
                 Leu Leu Gly Phe Ile Lys Pro Thr Lys Gln Lys Thr Asp His Val Ala 
               
               
                     690                 695                 700 
               
               
                   
               
               
                 Arg Leu Thr Trp Gly Gly Cys 
               
               
                 705                 710 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 187 
               
               
                 &lt;211&gt; LENGTH: 3116 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 187 
               
               
                   
               
               
                 gggttctctt gcaatggtta tagaaggctt gaagtacatc tggattcctt atgtgtgcat     60 
               
               
                   
               
               
                 gttagcagca tttggtgtat gttctcccga actttggatg acacttttca agtggcttcg    120 
               
               
                   
               
               
                 attaagaact gtacacccaa tattgttggc tcttattctg agcatggccg tgcctactat    180 
               
               
                   
               
               
                 aataggtctc agcttatgga aagagttttt tcccagatta atgacagaat taatggaact    240 
               
               
                   
               
               
                 acaggaattc tatgacccag atacagtgga acttatgacc tggataaaaa ggcaagctcc    300 
               
               
                   
               
               
                 agttgcagct gtgtttgcag ggagtccaca gttaatgggt gcgattaaat tatgcactgg    360 
               
               
                   
               
               
                 atggatggtg acaagtttgc ctctttacaa tgatgatgat cttctcaaga gaaatgaaaa    420 
               
               
                   
               
               
                 tatctaccaa atctattcaa agcgatctgc tgaggatatt tataaaatac tgacatctta    480 
               
               
                   
               
               
                 caaagctaat tacctaattg tagaggatgc tatctgcaat gaggtgggac ccatgagagg    540 
               
               
                   
               
               
                 ctgtagggtt aaagatttat tagacattgc aaatggccac atggtttgtg aagaaggtga    600 
               
               
                   
               
               
                 caagctaacc tactcaaaat atgggcgatt ttgtcatgag gtcaaaatta actattctcc    660 
               
               
                   
               
               
                 atatgtgaat tatttcacta gagtatactg gaacagatcc tactttgtat ataaaatcaa    720 
               
               
                   
               
               
                 cactgtgata tccttccagt cttgaaaaat aacagagcct tcatttcaaa gactacctga    780 
               
               
                   
               
               
                 agtaaaatgc agttttcttc tacctactcg gtgtcttttg cagatcagag tatggacatt    840 
               
               
                   
               
               
                 cgaaatattg ctgcttcttt cccccttctg ctgttaactg gatccagagt tctgtgggaa    900 
               
               
                   
               
               
                 atagaagatc aagcattact gtcctttgat taaatgtgat atctaccact ctgcaatatt    960 
               
               
                   
               
               
                 ccagacaggt gtcttcctta ccgttacatg gtctttaaca cttttactga ttgcaatatt   1020 
               
               
                   
               
               
                 ttccccataa aatcttcatt ctattataat attgatcttg aatttgaata tgtgcaaggt   1080 
               
               
                   
               
               
                 cagatacatt tctcaaacat aacatttaat aaataatgtg atataattat ttaatagaaa   1140 
               
               
                   
               
               
                 gaataattcc gaccttcaag caagtttctg aaggtatttt atgatgtata acaactgaag   1200 
               
               
                   
               
               
                 ttttacaata aaaactaatt taaatgttag ctgaagatat gtggcattta aattaaaatg   1260 
               
               
                   
               
               
                 gaaattatat aaaggaaagt gatttttaag gatatacata aagatatatt tagaattttc   1320 
               
               
                   
               
               
                 atgatactgt tctcctcatc tactgcttat gttaagtgag aactttctta gtaatacata   1380 
               
               
                   
               
               
                 atgcatgatg ttactgcatt ttctaaatga ctagtaagtg attagttttt tcacttatgc   1440 
               
               
                   
               
               
                 ctattaattt gataccaatt taatcatgat aaaacaataa ccgttaacat atattttgtt   1500 
               
               
                   
               
               
                 aaatggacat ttaaaagaat gttgttcagg tttttttttt aaatactgat atggggcata   1560 
               
               
                   
               
               
                 caatctattc acatgttttc tactgaagta ctaagtaaaa aaattaaatc attatcagaa   1620 
               
               
                   
               
               
                 taaaaatatg tgttctaaaa ttagcaacaa tttctgggga tacatgcaga tgttgttaaa   1680 
               
               
                   
               
               
                 cgtacctctg catacagata tattataaaa cacaagcaat gttatttatg aaactgtgat   1740 
               
               
                   
               
               
                 gcagtcttca acatcaagaa aaaatgacaa ctataataaa atttacaaca cagtttcaca   1800 
               
               
                   
               
               
                 gtctaaatgc tatgttcctt taagtatttt catattttta atcatttatt aagagaaaat   1860 
               
               
                   
               
               
                 tgtgaaaagt taatttggcc ttatagagag attcaggata gatgtagcct atagatgtgt   1920 
               
               
                   
               
               
                 cattttaata agttgggata catgtttagt ttttccttat attcctgttc agtgaacaga   1980 
               
               
                   
               
               
                 ttttcataat tctcacttgt taaagtgctg caaaaattgc attttcagta ctctaaatta   2040 
               
               
                   
               
               
                 ctacattaga agagagcatt tctccattgt ctttattttc tgttatatat gtgttgtaaa   2100 
               
               
                   
               
               
                 agtacactac attagaaggg agcttttccg ttgtctttat tttctgttat acatgtgttg   2160 
               
               
                   
               
               
                 ttaaagtaca tgcattctta gactaactct cagatgcttt gctcttttgg agctgaagaa   2220 
               
               
                   
               
               
                 ttgtttgatg gtgatgtcat atatctgata gattagtttc agtggttctc atttcacttt   2280 
               
               
                   
               
               
                 tatacgtaat ttcttaacta tattaagata gttgcaggca gtgtacctca ggttgactct   2340 
               
               
                   
               
               
                 gtacatctga atagtgagtc actagtattt tgcttcaagc cttctgaaaa tataaccata   2400 
               
               
                   
               
               
                 gttacctaag cacacagtga atagtcacat ggtagtactt gtgattagag catgtaaaac   2460 
               
               
                   
               
               
                 aatgtaattg aaaagtcagc ttccatattt tgtaggggaa atagaacacc ctacttttta   2520 
               
               
                   
               
               
                 tctagtgtga aatatttaat cgaatttttg ttgatttata ttatgttacc tgtgctgaat   2580 
               
               
                   
               
               
                 taggtttggt acttgtgttt tgtttgacat attagtaagt tgcttttgct tctttctgtc   2640 
               
               
                   
               
               
                 aacttatttt ttaaataaaa ttgatctgga aaaattgtta atgggatgtt ttaaataatg   2700 
               
               
                   
               
               
                 aatttttcat ccagcatcag ttgaaaagga aaagaaagct tcattatgga aatgacaata   2760 
               
               
                   
               
               
                 ttgaatatga cagataagtt tatttgcttc tgttttaact gcagttaata gtactagaca   2820 
               
               
                   
               
               
                 actttaagtg gaaagcattt agtttatttc ttcacttatt tgtagagtga acaaatgatt   2880 
               
               
                   
               
               
                 cacaattcta caagtaattc cacttaggta acttacagtt gttaggtttg acaataaaga   2940 
               
               
                   
               
               
                 tctactatga gaggagaaga atttatgggt tttgggtgga aggaatttct caaagaaata   3000 
               
               
                   
               
               
                 aaaaatgttc tttgcccttg atactgcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3060 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa       3116 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 188 
               
               
                 &lt;211&gt; LENGTH: 243 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 188 
               
               
                   
               
               
                 Met Val Ile Glu Gly Leu Lys Tyr Ile Trp Ile Pro Tyr Val Cys Met 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Leu Ala Ala Phe Gly Val Cys Ser Pro Glu Leu Trp Met Thr Leu Phe 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Lys Trp Leu Arg Leu Arg Thr Val His Pro Ile Leu Leu Ala Leu Ile 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Ser Met Ala Val Pro Thr Ile Ile Gly Leu Ser Leu Trp Lys Glu 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Phe Phe Pro Arg Leu Met Thr Glu Leu Met Glu Leu Gln Glu Phe Tyr 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Asp Pro Asp Thr Val Glu Leu Met Thr Trp Ile Lys Arg Gln Ala Pro 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Val Ala Ala Val Phe Ala Gly Ser Pro Gln Leu Met Gly Ala Ile Lys 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Leu Cys Thr Gly Trp Met Val Thr Ser Leu Pro Leu Tyr Asn Asp Asp 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Asp Leu Leu Lys Arg Asn Glu Asn Ile Tyr Gln Ile Tyr Ser Lys Arg 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Ser Ala Glu Asp Ile Tyr Lys Ile Leu Thr Ser Tyr Lys Ala Asn Tyr 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Leu Ile Val Glu Asp Ala Ile Cys Asn Glu Val Gly Pro Met Arg Gly 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Cys Arg Val Lys Asp Leu Leu Asp Ile Ala Asn Gly His Met Val Cys 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Glu Glu Gly Asp Lys Leu Thr Tyr Ser Lys Tyr Gly Arg Phe Cys His 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Glu Val Lys Ile Asn Tyr Ser Pro Tyr Val Asn Tyr Phe Thr Arg Val 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Tyr Trp Asn Arg Ser Tyr Phe Val Tyr Lys Ile Asn Thr Val Ile Ser 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Phe Gln Ser 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 189 
               
               
                 &lt;211&gt; LENGTH: 839 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 189 
               
               
                   
               
               
                 ggtatcaggg ccgggagccc tttgggagga agggaggcgt tagaggagct gccttcggag     60 
               
               
                   
               
               
                 gctcagggag tccctttgga gctggttgtt tccttggccc tgcagcgcac tgctcggggc    120 
               
               
                   
               
               
                 tcccaaggag gttgtgtgta tggttcttaa ttcatcagga caaagacccc cagcatgtgt    180 
               
               
                   
               
               
                 gtaccctggg acccgatttc tctgggccca catctatctc caatacctca gcctcagatc    240 
               
               
                   
               
               
                 agaccctttc ttttttgtct ttcttctctt aatttttaaa tgcctctttt cttgagcatt    300 
               
               
                   
               
               
                 ccatctctct ttttgaccct ctcaggactg ggcttagctg tccagagccc tgccggaggg    360 
               
               
                   
               
               
                 tgctgggggc tgtccctctg caggcactgt gttttcctca ggggctgtcc tcagaacacc    420 
               
               
                   
               
               
                 cctcctgctc cctggggctc ctcagggagc catttcagct ggagtctcag gtctcaaaaa    480 
               
               
                   
               
               
                 caacttctcc aggaggccaa aaaaagactg ggttggcttc tggtcctcat gacggctttt    540 
               
               
                   
               
               
                 atcctcctgg gacactttgg gtatattcat gggcattgtt tccatctgtc ttttctacct    600 
               
               
                   
               
               
                 gtgccacccc tgccctgatt ccacggctgc ctcaggcagg caggcaagga gctaggccgg    660 
               
               
                   
               
               
                 tgcccggccc tggcagcaag gggtctttgt gcagttggag atgctgccgt tgtggcagag    720 
               
               
                   
               
               
                 cgtcctgcag ccccgcttcc atcagcaggc tctggggtgg gggctttgca ggggatgctc    780 
               
               
                   
               
               
                 tctgatgttt gttccgttgt ttaaataaaa tgcacttatt tttgtttttt tttttgcta     839 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 190 
               
               
                 &lt;211&gt; LENGTH: 112 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 190 
               
               
                   
               
               
                 Met Pro Leu Phe Leu Ser Ile Pro Ser Leu Phe Leu Thr Leu Ser Gly 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Leu Gly Leu Ala Val Gln Ser Pro Ala Gly Gly Cys Trp Gly Leu Ser 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Leu Cys Arg His Cys Val Phe Leu Arg Gly Cys Pro Gln Asn Thr Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Pro Ala Pro Trp Gly Ser Ser Gly Ser His Phe Ser Trp Ser Leu Arg 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ser Gln Lys Gln Leu Leu Gln Glu Ala Lys Lys Arg Leu Gly Trp Leu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Val Leu Met Thr Ala Phe Ile Leu Leu Gly His Phe Gly Tyr Ile 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 His Gly His Cys Phe His Leu Ser Phe Leu Pro Val Pro Pro Leu Pro 
               
               
                             100                 105                 110 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 191 
               
               
                 &lt;211&gt; LENGTH: 491 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 191 
               
               
                   
               
               
                 gtcagggcca gggccagaga gccggagaga ggagcccccg accgagagcc caggtagagc     60 
               
               
                   
               
               
                 gcacagaggt gcttcgctcc tgttccagcc ctgtcttctc ccgggtgctg gcccttgagt    120 
               
               
                   
               
               
                 atttttttga ggagaagcag cccctgcagt tccacgtgtt cgatgccgag gacggagcca    180 
               
               
                   
               
               
                 ccagccctag cccgtgactg cctccctccg gaccgacact ccctcagcct ctcagtgcct    240 
               
               
                   
               
               
                 gtcctgaccc tcgtgactcc agtgaccaat gcctccacct cttggaccag gtgtgccccc    300 
               
               
                   
               
               
                 tgggttctgg acgtgagtgg tgggtcctgc tcctatctct ccaaacccca tacccttcaa    360 
               
               
                   
               
               
                 tgctgtggcc cctcagtgac ttccttgggt gatcctgact ttctagccat taataaagag    420 
               
               
                   
               
               
                 aactgctcct agcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    480 
               
               
                   
               
               
                 aaaaaaaaaa a                                                         491 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 192 
               
               
                 &lt;211&gt; LENGTH: 89 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;400&gt; SEQUENCE: 192 
               
               
                   
               
               
                 Met Pro Arg Thr Glu Pro Pro Ala Leu Ala Arg Asp Cys Leu Pro Pro 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Asp Arg His Ser Leu Ser Leu Ser Val Pro Val Leu Thr Leu Val Thr 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Pro Val Thr Asn Ala Ser Thr Ser Trp Thr Arg Cys Ala Pro Trp Val 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Asp Val Ser Gly Gly Ser Cys Ser Tyr Leu Ser Lys Pro His Thr 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Gln Cys Cys Gly Pro Ser Val Thr Ser Leu Gly Asp Pro Asp Phe 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Ala Ile Asn Lys Glu Asn Cys Ser 
               
               
                                  85 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 193 
               
               
                 &lt;211&gt; LENGTH: 2619 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 193 
               
               
                   
               
               
                 atcgtgagtg ctcggtaaat atctgtggct ttaatggatg aatgaatgaa tgactacatg     60 
               
               
                   
               
               
                 gctaaactcc attctagggc aacatctgtg gctgcagtgg atgggcccta gtgaatggat    120 
               
               
                   
               
               
                 atttaacgga tatcgtacta ttcctcatct ccacagggtc aggctgtgcc acatccaccc    180 
               
               
                   
               
               
                 agccttgcct ggggtcattt atcctacatg tactcagatc acgtgaactg gtgatgggcc    240 
               
               
                   
               
               
                 acccatgtgc ctgcctggag actcctattc acccttcaga tcaatatccc ccaaataaac    300 
               
               
                   
               
               
                 tcccagtcac tctggcatcc catgttgctt tgtgatctct gcctctctct agaccatttg    360 
               
               
                   
               
               
                 gctcctatgc acaggcagct atgtcttttt catatttggg tccccaaaat gcacagtgcg    420 
               
               
                   
               
               
                 gtgcctgcct caaaacaaat gcttttcaat ccgtcaatca atcagttgac atggatcatc    480 
               
               
                   
               
               
                 ttttctcagc actgatgtat ggactacaac ttggaattcc attaaagctc ctggggtcaa    540 
               
               
                   
               
               
                 gaaaaaaagt gattcaagtt tatttattta tttttttttg agacagagtc tcattctgtc    600 
               
               
                   
               
               
                 gcccaggctg gagtgcagtg gcacgatctt ggctcactgc aacctctgcc tctggggttc    660 
               
               
                   
               
               
                 aagtgattct cactcatgcc tcagcctccc aagtagctgg gcaagagcca gcacacccgg    720 
               
               
                   
               
               
                 gctaattttt gtatttttag tagggacggg ctttcgccat gttggccaga ctggtctcga    780 
               
               
                   
               
               
                 gctcctggct tcaagtgatc tgcccacttc agcctcccaa agtgctggga ttacaggcat    840 
               
               
                   
               
               
                 ttaatcactg cacccgggtg agccactgca cccggccaag ttcatattct aaaagtgaaa    900 
               
               
                   
               
               
                 cattaatgct gcattgtgta ttttttggtc aagtgcttca gatgtgtgga aggaatttct    960 
               
               
                   
               
               
                 ttgtataaat gcaattattc gtcaccatga tgataattat aacgagggtg actgcacaga   1020 
               
               
                   
               
               
                 actgtgcctc cccagcaagc atgggctggg cagggccggg tattcccttc gctgacttgc   1080 
               
               
                   
               
               
                 ttcactagtt gactaacaga ccttattccc gggcctgagc tgatgatatc ctgccaatgc   1140 
               
               
                   
               
               
                 cagcttccca acatggaggg gacgcaagag cgagcgccat gggatcctgg gggaaaagca   1200 
               
               
                   
               
               
                 gcctgtgttt gctgctgctt tgacagttga ggctctgaga gggactggca aacaatggga   1260 
               
               
                   
               
               
                 aatgaaacat ttgagtggtt gcaaaaaatt ccatgggaaa tcccccctgg tggtatttat   1320 
               
               
                   
               
               
                 gtgcgacggc tgtgacaagg agagcgcagg gctttcgatt tcaagggttc ctgagcagac   1380 
               
               
                   
               
               
                 cacaatggcc ttccaagatg gcaatccccg ggaacagctc tctcggccac aaaaggccag   1440 
               
               
                   
               
               
                 tttgtctgtc cagggaagat ctggccccat gcatcaagtt ggccatgagc tgcagtgtct   1500 
               
               
                   
               
               
                 tctttggggc atgacccaca tttatagggt ctgggcctct gaaccttctg ctcctaagac   1560 
               
               
                   
               
               
                 agatctatct cagttgtccc tctggttttc ccaggcctca aggacctggg ggctgatggg   1620 
               
               
                   
               
               
                 ggctgagggg tttccctcgg gctcagcctc catctgcaga actgtgggaa cctcagcctc   1680 
               
               
                   
               
               
                 catcagaccc ctccccattt tctggtcagc acgtggcctc ctcctgtttc ctccattccc   1740 
               
               
                   
               
               
                 gttggtaatg gacatttatt taacttttac tccccctcca ttctcattta gaaaagaaag   1800 
               
               
                   
               
               
                 tgaactgata ttaaccaatc tttgttttgc cttctttaac actaatgcat atgcaaaata   1860 
               
               
                   
               
               
                 gttaccacta ttgataatat cttattgctg ctgtgatata tgtgtgtata tgtacagatc   1920 
               
               
                   
               
               
                 tgcttgaagg taagctttat atagattttt agagatactt ggtaaatgag aaaatggaaa   1980 
               
               
                   
               
               
                 ctgaaagagg ttaaataaac tgcccatgtg tattggtcat gaggtttcag ttgcaaagtg   2040 
               
               
                   
               
               
                 acaaaatcct gacttagatg aacttaaacc ggatggaaaa tgtacattgt attatttgag   2100 
               
               
                   
               
               
                 aagcaaggtc tggataagct tcaggcatgg ctggatccag gccctcagtt aagtctttag   2160 
               
               
                   
               
               
                 gaatttccct ctctctagct ttttggcttt gcttttccct gtattggttt catgtttaga   2220 
               
               
                   
               
               
                 ttggctcact tcacctgttt tacatctttc cagagtcaaa tccagccttt ttcctggttg   2280 
               
               
                   
               
               
                 cctccataaa agtcccaggg ttaggtttag tgtgctctga tagattcagc tgcccattgc   2340 
               
               
                   
               
               
                 tgaagcagtg actctggcaa cagggatgga ctgatctaag tgcccaggtt ccagtcactg   2400 
               
               
                   
               
               
                 ctgaagccca gccagaccac ctggacacag taagagtgag tggttccccc aaagaaaact   2460 
               
               
                   
               
               
                 ggggtgctct taccagaaga aggaggaatc gacaaaaaga cctgatgtcc taaactcccg   2520 
               
               
                   
               
               
                 tgtcacactg tcactaatgg gcaggcagac ccatacagca gctcctctgc atcttcatgc   2580 
               
               
                   
               
               
                 tgctagagac caccaccacg aaacaaaaaa aaaaaaaaa                          2619 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 194 
               
               
                 &lt;211&gt; LENGTH: 199 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 194 
               
               
                   
               
               
                 Met Lys His Leu Ser Gly Cys Lys Lys Phe His Gly Lys Ser Pro Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Val Val Phe Met Cys Asp Gly Cys Asp Lys Glu Ser Ala Gly Leu Ser 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ile Ser Arg Val Pro Glu Gln Thr Thr Met Ala Phe Gln Asp Gly Asn 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Pro Arg Glu Gln Leu Ser Arg Pro Gln Lys Ala Ser Leu Ser Val Gln 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gly Arg Ser Gly Pro Met His Gln Val Gly His Glu Leu Gln Cys Leu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Trp Gly Met Thr His Ile Tyr Arg Val Trp Ala Ser Glu Pro Ser 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ala Pro Lys Thr Asp Leu Ser Gln Leu Ser Leu Trp Phe Ser Gln Ala 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ser Arg Thr Trp Gly Leu Met Gly Ala Glu Gly Phe Pro Ser Gly Ser 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Ala Ser Ile Cys Arg Thr Val Gly Thr Ser Ala Ser Ile Arg Pro Leu 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Pro Ile Phe Trp Ser Ala Arg Gly Leu Leu Leu Phe Pro Pro Phe Pro 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Leu Val Met Asp Ile Tyr Leu Thr Phe Thr Pro Pro Pro Phe Ser Phe 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Arg Lys Glu Ser Glu Leu Ile Leu Thr Asn Leu Cys Phe Ala Phe Phe 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Asn Thr Asn Ala Tyr Ala Lys 
               
               
                         195 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 195 
               
               
                 &lt;211&gt; LENGTH: 2874 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 195 
               
               
                   
               
               
                 gaagaaagca aaagttcaga agagatgtca gtagaaaaca aaaataggac cagagatcaa     60 
               
               
                   
               
               
                 gaagccccag aggatgtaca agtcaggcca gaggatactc cttcagatct cagtgttagt    120 
               
               
                   
               
               
                 aattccagtg tcatactgga aaacacgatg gaagaccatg ctgctgaggc atccgggaag    180 
               
               
                   
               
               
                 cctctaggtg aaattagtgt tccactggac agctctttac tttgtacttt gtcctcagaa    240 
               
               
                   
               
               
                 tctcaccagg aagcagctag taatgagaat gataaaaaac ctggtaacta caaatctatg    300 
               
               
                   
               
               
                 ttacgaccag aggttggcac cacttcacaa gattcagctc tcttagatca ggaattgtat    360 
               
               
                   
               
               
                 aactccttcc atttctggag gactcctctt cctgaaatag atctagacat agagcttgaa    420 
               
               
                   
               
               
                 cagaactctg ggggaaaacc cagcccagag ggaccagagg aagaatctga gggccctgtg    480 
               
               
                   
               
               
                 cccagttctc caaacatcac catggccacc agaaaggaac tggaagaaat gatagaaaat    540 
               
               
                   
               
               
                 ctagagcccc acattgatga tccagatgtt aaagcacaag tggaagtgct gtccgctgca    600 
               
               
                   
               
               
                 ctacgtgctt ccagcctgga tgcacatgaa gagaccatca gtatagaaaa gagaagtgat    660 
               
               
                   
               
               
                 ttgcaagatg aactggatat aaatgagcta ccaaattgta aaataaatca agaagattct    720 
               
               
                   
               
               
                 gtgcctttaa tcagcgatgc tgttgagaat atggactcca ctcttcacta tattcacagc    780 
               
               
                   
               
               
                 gattcagact tgagcaacaa tagcagtttt agccctgatg aggaaaggag aactaaagta    840 
               
               
                   
               
               
                 caagatgttg tacctcaggc gttgttagat cagtatttat ctatgactga cccttctcgt    900 
               
               
                   
               
               
                 gcacagacgg ttgacactga aattgctaag cactgtgcat atagcctccc tggtgtggcc    960 
               
               
                   
               
               
                 ttgacactcg gaagacagaa ttggcactgc ctgagagaga cgtatgagac tctggcctca   1020 
               
               
                   
               
               
                 gacatgcagt ggaaagttcg acgaactcta gcattctcca ttcacgagct tgcagttatt   1080 
               
               
                   
               
               
                 cttggagatc aattgacagc tgcagatctg gttccaattt ttaatggatt tttaaaagac   1140 
               
               
                   
               
               
                 ctcgatgaag tcaggatagg tgttcttaaa cacttgcatg attttctgaa gcttcttcat   1200 
               
               
                   
               
               
                 attgacaaaa gaagagaata tctttatcaa cttcaggagt ttttggtgac agataatagt   1260 
               
               
                   
               
               
                 agaaattggc ggtttcgagc tgaactggct gaacagctga ttttacttct agagttatat   1320 
               
               
                   
               
               
                 agtcccagag atgtttatga ctatttacgt cccattgctc tgaatctgtg tgcagacaaa   1380 
               
               
                   
               
               
                 gtttcttctg ttcgttggat ttcctacaag ttggtcagcg agatggtgaa gaagctgcac   1440 
               
               
                   
               
               
                 gcggcaacac caccaacgtt cggagtggac ctcatcaatg agcttgtgga gaactttggc   1500 
               
               
                   
               
               
                 agatgtccca agtggtctgg tcggcaagcc tttgtctttg tctgccagac tgtcattgag   1560 
               
               
                   
               
               
                 gatgactgcc ttcccatgga ccagtttgct gtgcatctca tgccgcatct gctaacctta   1620 
               
               
                   
               
               
                 gcaaatgaca gggttcctaa cgtgcgagtg ctgcttgcaa agacattaag acaaactcta   1680 
               
               
                   
               
               
                 ctagaaaaag actatttctt ggcctttgcc agctgccacc aggaggctgt ggagcagacc   1740 
               
               
                   
               
               
                 atcatggctc ttcagatgga ccgtgacagc gatgtcaagt attttgcaag catccaccct   1800 
               
               
                   
               
               
                 gccagtacca aaatctccga agatgccatg agcacagcgt cctcaaccta ctagaaggct   1860 
               
               
                   
               
               
                 tgaatctcgg tgtctttcct gcttccatga gagccgaggt tcagtgggca ttcgccacgc   1920 
               
               
                   
               
               
                 atgtgacctg ggatagcttt cgggggagga gagaccttcc tctcctgcgg acttcattgc   1980 
               
               
                   
               
               
                 aggtgcaagt tgcctacacc caataccagg gatttcaaga gtcaagagaa agtacagtaa   2040 
               
               
                   
               
               
                 acactattat cttatcttga ctttaagggg aaataatttc tcagaggatt ataattgtca   2100 
               
               
                   
               
               
                 ccgaagcctt aaatccttct gtcttcctga ctgaatgaaa cttgaattgg cagagcattt   2160 
               
               
                   
               
               
                 tccttatgga agggatgaga ttcccagaga cctgcattgc tttctcctgg ttttatttaa   2220 
               
               
                   
               
               
                 caatcgacaa atgaaattct tacagcctga aggcagacgt gtgcccagat gtgaaagaga   2280 
               
               
                   
               
               
                 ccttcagtat cagccctaac tcttctctcc caggaaggac ttgctgggct ctgtggccag   2340 
               
               
                   
               
               
                 ctgtccagcc cagccctgtg tgtgaatcgt ttgtgacgtg tgcaaatggg aaaggagggg   2400 
               
               
                   
               
               
                 tttttacatc tcctaaagga cctgatgcca acacaagtag gattgactta aactcttaag   2460 
               
               
                   
               
               
                 cgcagcatat tgctgtacac atttacagaa tggttgctga gtgtctgtgt ctgatttttt   2520 
               
               
                   
               
               
                 catgctggtc atgacctgaa ggaaatttat tagacgtata atgtatgtct ggtgttttta   2580 
               
               
                   
               
               
                 acttgatcat gatcagctct gaggtgcaac ttcttcacat actgtacata cctgtgacca   2640 
               
               
                   
               
               
                 ctcttgggag tgctgcagtc tttaatcatg ctgtttaaac tgttgtggca caagttctct   2700 
               
               
                   
               
               
                 tgtccaaata aaatttatta ataagatcta tagagagaga tatatacact tttgattgtt   2760 
               
               
                   
               
               
                 ttctagatgt ctaccaataa atgcaatttg tgacctgtat taatgattta aagtggggaa   2820 
               
               
                   
               
               
                 actagattaa aatatttgtc ttttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa         2874 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 196 
               
               
                 &lt;211&gt; LENGTH: 609 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 196 
               
               
                   
               
               
                 Met Ser Val Glu Asn Lys Asn Arg Thr Arg Asp Gln Glu Ala Pro Glu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Asp Val Gln Val Arg Pro Glu Asp Thr Pro Ser Asp Leu Ser Val Ser 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Asn Ser Ser Val Ile Leu Glu Asn Thr Met Glu Asp His Ala Ala Glu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ala Ser Gly Lys Pro Leu Gly Glu Ile Ser Val Pro Leu Asp Ser Ser 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Leu Cys Thr Leu Ser Ser Glu Ser His Gln Glu Ala Ala Ser Asn 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Glu Asn Asp Lys Lys Pro Gly Asn Tyr Lys Ser Met Leu Arg Pro Glu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Val Gly Thr Thr Ser Gln Asp Ser Ala Leu Leu Asp Gln Glu Leu Tyr 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Asn Ser Phe His Phe Trp Arg Thr Pro Leu Pro Glu Ile Asp Leu Asp 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Ile Glu Leu Glu Gln Asn Ser Gly Gly Lys Pro Ser Pro Glu Gly Pro 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Glu Glu Glu Ser Glu Gly Pro Val Pro Ser Ser Pro Asn Ile Thr Met 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Ala Thr Arg Lys Glu Leu Glu Glu Met Ile Glu Asn Leu Glu Pro His 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Ile Asp Asp Pro Asp Val Lys Ala Gln Val Glu Val Leu Ser Ala Ala 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Leu Arg Ala Ser Ser Leu Asp Ala His Glu Glu Thr Ile Ser Ile Glu 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Lys Arg Ser Asp Leu Gln Asp Glu Leu Asp Ile Asn Glu Leu Pro Asn 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Cys Lys Ile Asn Gln Glu Asp Ser Val Pro Leu Ile Ser Asp Ala Val 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Glu Asn Met Asp Ser Thr Leu His Tyr Ile His Ser Asp Ser Asp Leu 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Ser Asn Asn Ser Ser Phe Ser Pro Asp Glu Glu Arg Arg Thr Lys Val 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Gln Asp Val Val Pro Gln Ala Leu Leu Asp Gln Tyr Leu Ser Met Thr 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Asp Pro Ser Arg Ala Gln Thr Val Asp Thr Glu Ile Ala Lys His Cys 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Ala Tyr Ser Leu Pro Gly Val Ala Leu Thr Leu Gly Arg Gln Asn Trp 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 His Cys Leu Arg Glu Thr Tyr Glu Thr Leu Ala Ser Asp Met Gln Trp 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Lys Val Arg Arg Thr Leu Ala Phe Ser Ile His Glu Leu Ala Val Ile 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Leu Gly Asp Gln Leu Thr Ala Ala Asp Leu Val Pro Ile Phe Asn Gly 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 Phe Leu Lys Asp Leu Asp Glu Val Arg Ile Gly Val Leu Lys His Leu 
               
               
                     370                 375                 380 
               
               
                   
               
               
                 His Asp Phe Leu Lys Leu Leu His Ile Asp Lys Arg Arg Glu Tyr Leu 
               
               
                 385                 390                 395                 400 
               
               
                   
               
               
                 Tyr Gln Leu Gln Glu Phe Leu Val Thr Asp Asn Ser Arg Asn Trp Arg 
               
               
                                 405                 410                 415 
               
               
                   
               
               
                 Phe Arg Ala Glu Leu Ala Glu Gln Leu Ile Leu Leu Leu Glu Leu Tyr 
               
               
                             420                 425                 430 
               
               
                   
               
               
                 Ser Pro Arg Asp Val Tyr Asp Tyr Leu Arg Pro Ile Ala Leu Asn Leu 
               
               
                         435                 440                 445 
               
               
                   
               
               
                 Cys Ala Asp Lys Val Ser Ser Val Arg Trp Ile Ser Tyr Lys Leu Val 
               
               
                     450                 455                 460 
               
               
                   
               
               
                 Ser Glu Met Val Lys Lys Leu His Ala Ala Thr Pro Pro Thr Phe Gly 
               
               
                 465                 470                 475                 480 
               
               
                   
               
               
                 Val Asp Leu Ile Asn Glu Leu Val Glu Asn Phe Gly Arg Cys Pro Lys 
               
               
                                 485                 490                 495 
               
               
                   
               
               
                 Trp Ser Gly Arg Gln Ala Phe Val Phe Val Cys Gln Thr Val Ile Glu 
               
               
                             500                 505                 510 
               
               
                   
               
               
                 Asp Asp Cys Leu Pro Met Asp Gln Phe Ala Val His Leu Met Pro His 
               
               
                         515                 520                 525 
               
               
                   
               
               
                 Leu Leu Thr Leu Ala Asn Asp Arg Val Pro Asn Val Arg Val Leu Leu 
               
               
                     530                 535                 540 
               
               
                   
               
               
                 Ala Lys Thr Leu Arg Gln Thr Leu Leu Glu Lys Asp Tyr Phe Leu Ala 
               
               
                 545                 550                 555                 560 
               
               
                   
               
               
                 Phe Ala Ser Cys His Gln Glu Ala Val Glu Gln Thr Ile Met Ala Leu 
               
               
                                 565                 570                 575 
               
               
                   
               
               
                 Gln Met Asp Arg Asp Ser Asp Val Lys Tyr Phe Ala Ser Ile His Pro 
               
               
                             580                 585                 590 
               
               
                   
               
               
                 Ala Ser Thr Lys Ile Ser Glu Asp Ala Met Ser Thr Ala Ser Ser Thr 
               
               
                         595                 600                 605 
               
               
                   
               
               
                 Tyr 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 197 
               
               
                 &lt;211&gt; LENGTH: 2029 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 197 
               
               
                   
               
               
                 agcagccgaa tcttgagact gtcaatgaca gaaagctgaa gagaggcctc tatttcttcc     60 
               
               
                   
               
               
                 tttttccttt cttctgtcta aaaactctct cttgttcccc ttttccagct tcccttggac    120 
               
               
                   
               
               
                 tactgcccca atggcccctt ggactcgcgt ttcatgtatg cgagcacaca cacacacaaa    180 
               
               
                   
               
               
                 cttgcaaaat accgtttttc ttaaggattg tgggaccgaa taatatcacg tgccttcatc    240 
               
               
                   
               
               
                 ttttcctttt atagttagat gaacctcttc ctctttacaa tttttttaaa aagtgatagg    300 
               
               
                   
               
               
                 ggaggttgat gtgttagtgg aagatttggg catcgtttga gaagtaactt ttgtttaaca    360 
               
               
                   
               
               
                 cattccccct aaacattgaa cacaaacatt tcaacccctt catgacactc tttggacatt    420 
               
               
                   
               
               
                 taaagcattg agtaaccatg tacatgacag cctaaatccg tttgatttca gagcatttcc    480 
               
               
                   
               
               
                 tgaacattgt atttcataga cttctctgat tttttcaaaa atgaggtgag caatggcaag    540 
               
               
                   
               
               
                 cagccttgtt ctcccaattt ggtgcttttg cttttggtgt ggggtgggca tggggggttg    600 
               
               
                   
               
               
                 ggggtggtgt gggtgtgttt agaaaaaaga tgcattcctg aagatctctg gtgctgaagg    660 
               
               
                   
               
               
                 gcctcgagtt cctttcagag actgtatttg acacacttta ggtacacaca aacgaatggt    720 
               
               
                   
               
               
                 atcacatgca atattttaat ggagcaatgg gagaggctct ttgaaatggg gtttgcatct    780 
               
               
                   
               
               
                 ttttgtaaca ttatgatttc tctggtgcct tattcctact tgatgctggc actcacatac    840 
               
               
                   
               
               
                 ccacaagaag ctgacacaga agtcagcctt aggcgtgggg acatatgggt gatgtttgag    900 
               
               
                   
               
               
                 catgcagggg ccatggggag tttggtgtca gatggtggag aagggactag atggcatctc    960 
               
               
                   
               
               
                 ttagccgagg ccaacaggaa ctgcacaagt ccattatagt caaagttagc aattttgata   1020 
               
               
                   
               
               
                 cgtaaacaca atacttcatt cttcctcatc tgagctttcc ttccttcttc cttttctatc   1080 
               
               
                   
               
               
                 tctaccttct cataaaggtg ctgctgctgc tgctaaggtg cccggagtcc agaatgtcca   1140 
               
               
                   
               
               
                 ttaatcactc aggcacgagc ctggcactgc cacgtcagcc cccagcatga ccaaacccag   1200 
               
               
                   
               
               
                 gtttctcttg cttggggctg agaactgtca gatttttctc atcaaaaatg ttttccaagg   1260 
               
               
                   
               
               
                 aatcagtgga ttacagtttt tctgcattga aaatgcactt taaaaaataa attaaagctc   1320 
               
               
                   
               
               
                 cagactgttt aaaatataca gagggagcag gggaaagtta agcatgtgct agtgtctgaa   1380 
               
               
                   
               
               
                 cccagttcag tttatctcca gttgaaacga tatacactat attatgtata aatgtataca   1440 
               
               
                   
               
               
                 cacttcctat atgtatccac atatatatag tgtatatatt atacatgtat aggtgtgtat   1500 
               
               
                   
               
               
                 atgtgcatat atacacacat gcacataaca aaatcagatg ctcattacaa atccagatgc   1560 
               
               
                   
               
               
                 tcattacaaa accagatgct acacaaacag cagcagagga aacaaggttg gactcttgca   1620 
               
               
                   
               
               
                 acagatcaca aaaaataaaa acagctactt gcagtgactt tggtcatttc tgtatgttca   1680 
               
               
                   
               
               
                 taaagaatgg attgtaacaa ggaaaaaaag gaacagtgtt agtgaaaaag gaaaaatggg   1740 
               
               
                   
               
               
                 cgaaaccatc ttgatccgat gcgaatgcag taatgttcta tataccattt catcagttat   1800 
               
               
                   
               
               
                 ttcttttagt catgttgatt tgatttcagt ttctggctat gaaaaacatt tttaaactcg   1860 
               
               
                   
               
               
                 tcacccacaa caaactgaac aaaactacta cagtgaaagc ccttttcagt gaaagatgtc   1920 
               
               
                   
               
               
                 agaaacctca aaacctttgg cctgactcag aactaccatg tgaaaatcag tactctctta   1980 
               
               
                   
               
               
                 atgtttgaaa taaaaactga aaaaaaaaaa aaaaaaaaaa aaaaaaaaa               2029 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 198 
               
               
                 &lt;211&gt; LENGTH: 86 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 198 
               
               
                   
               
               
                 Met Glu Gln Trp Glu Arg Leu Phe Glu Met Gly Phe Ala Ser Phe Cys 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Asn Ile Met Ile Ser Leu Val Pro Tyr Ser Tyr Leu Met Leu Ala Leu 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Thr Tyr Pro Gln Glu Ala Asp Thr Glu Val Ser Leu Arg Arg Gly Asp 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ile Trp Val Met Phe Glu His Ala Gly Ala Met Gly Ser Leu Val Ser 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Asp Gly Gly Glu Gly Thr Arg Trp His Leu Leu Ala Glu Ala Asn Arg 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Asn Cys Thr Ser Pro Leu 
               
               
                                  85 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 199 
               
               
                 &lt;211&gt; LENGTH: 2304 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 199 
               
               
                   
               
               
                 cagggtctgg ccactgcaca gccaggcacg ctggctgctg tggcagggtg ggaagctcca     60 
               
               
                   
               
               
                 tatgccagct ccctttgagg ctgcggctgg accagatgtg ccacaagtgg cttccactgt    120 
               
               
                   
               
               
                 gggcaccagc gtctggataa agggaatgtg gtggtgcccg aaagctcaga gacaccagga    180 
               
               
                   
               
               
                 actgcagagt ccccaaatag gtgttacagc atgtcacagc catggctcag ggagcaccaa    240 
               
               
                   
               
               
                 ggtctgggct tccagaaggg ctgcagctct tctctacttc ttgttatcta cagtgtggtg    300 
               
               
                   
               
               
                 agtgggggga catgtttcag cccatttgtg ttacagctct ttcagtccca ccaccttgct    360 
               
               
                   
               
               
                 ctggcccgtg gctcatgggc tggaccagcc ccactgctgc ttcccatcat gtggggtggc    420 
               
               
                   
               
               
                 cactcagcac cagcagaggg tgggagggct atagtgttaa cagcagctcc agctctgagg    480 
               
               
                   
               
               
                 tctgggcccc cagaagggtt gccatccttt actcccatag cccaggagca tgtcaccacc    540 
               
               
                   
               
               
                 cacagctcag cgagctggtc aagaacatgt tacagctcct ttcacttccg ccgttcagca    600 
               
               
                   
               
               
                 ggtcctgagt tcttgtcccg tgtctaggaa gaatgaggtt atgcagacaa ctgggtgaac    660 
               
               
                   
               
               
                 aaggcaggca ggagctttat tgagtgacag aacagctgtc aggagaccca aagtgggtag    720 
               
               
                   
               
               
                 ctcctttcta caggtggtcc agacaagtgt cttaggctgg ctgagtctgg ggtttttaag    780 
               
               
                   
               
               
                 ggctcagaag ggaggaaggg catgctgatt ggtccatagg tggtcatagg caggcctgga    840 
               
               
                   
               
               
                 aaaagcacca tctgattggc aaaaggcatc agtgaagttc tcactccagg ttgcggactc    900 
               
               
                   
               
               
                 cacctggaac ggacagctga gcccccaggc ttcaggccat ccctggctta aaggtagggt    960 
               
               
                   
               
               
                 ttcactagag acccacccct tcctgcctag gaacctgtct gcctcccact gccatcaaca   1020 
               
               
                   
               
               
                 tgccatccat ggcacccagg ctatctgcac tgaggggcac ccacatgccc acgctcagct   1080 
               
               
                   
               
               
                 gccctcaatg cccccagcct ccctcccaca ctcatcactg cccgaagtcc agaaagggct   1140 
               
               
                   
               
               
                 gaggcagcag ggtgctgggt ctgccacaac tttgcttcgc actggagcgg gcacttggag   1200 
               
               
                   
               
               
                 agaggagagg ccagagagtg ggaacaggca cctctgcctg aaggaatagg gggcttccca   1260 
               
               
                   
               
               
                 ggccctggag agtgcaggga tgcccaggtc cacagctggg cagctgcaac tgcctgggag   1320 
               
               
                   
               
               
                 aacaggctcc catcctgcca gcttggtagg gcgcagggct cctgctggga tcacctattc   1380 
               
               
                   
               
               
                 ctggcccctg ccagctccac agagtgcaca atcccagcca tggcttcccc cactgcagct   1440 
               
               
                   
               
               
                 ggcgtcctca cagcagccac cccagatggg ccactgctgc tgtcaacagt tggcaggaag   1500 
               
               
                   
               
               
                 gcaggctaag cctggtgtct caaccagagg actttgcagc agaggtaatt gccaacccca   1560 
               
               
                   
               
               
                 cttccactgc cttgacgtcc ctcttgcagc agagaagcta atcctgccca gcctggccat   1620 
               
               
                   
               
               
                 gagtgagggc acctgaaggg gtgaggaggc gggggtaatg ttgtgtaggt gggagggggc   1680 
               
               
                   
               
               
                 agtagagagt cccatactca aagtgactgc caaatccagg gctgtgcata gagtgactgc   1740 
               
               
                   
               
               
                 tgacagcctt tgataagctt tgctgtgagt ccaaaagaat gatcggatag atgcctgtct   1800 
               
               
                   
               
               
                 tgcagcgcat ctacattaat ctcatagcaa attattcgtc tcatattaga gaaagtttag   1860 
               
               
                   
               
               
                 ctttcttaga agcttgatgg gaaagagcct cccagctctt agagtttgat tttcgcaact   1920 
               
               
                   
               
               
                 cagttcacat cttcttctta ctccaggttc ccagctcctt gagccttgcc cgtgaagggg   1980 
               
               
                   
               
               
                 ttggagtcag gatgggaagc cttgagctgc cttgacctgc tccatctctg actcagggat   2040 
               
               
                   
               
               
                 gtgccctgct tgtcacagca tgggtgtgct gggccttggg gcatcttttc aggcagagag   2100 
               
               
                   
               
               
                 caagacgttg gcattgtgga aagctgtccc tccaaacagc agcccattca cagactacag   2160 
               
               
                   
               
               
                 aggaagaaaa gaccacactt gctacagtaa caatgcaatt cagtaccagg gaataactta   2220 
               
               
                   
               
               
                 acatgaaaca tgtcaaatct atgtaaacaa ctggaaggca ctcctaaaaa atacaaaaaa   2280 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa aaaa                                          2304 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 200 
               
               
                 &lt;211&gt; LENGTH: 128 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 200 
               
               
                   
               
               
                 Met Ala Gln Gly Ala Pro Arg Ser Gly Leu Pro Glu Gly Leu Gln Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Phe Ser Thr Ser Cys Tyr Leu Gln Cys Gly Glu Trp Gly Asp Met Phe 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gln Pro Ile Cys Val Thr Ala Leu Ser Val Pro Pro Pro Cys Ser Gly 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Pro Trp Leu Met Gly Trp Thr Ser Pro Thr Ala Ala Ser His His Val 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gly Trp Pro Leu Ser Thr Ser Arg Gly Trp Glu Gly Tyr Ser Val Asn 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ser Ser Ser Ser Ser Glu Val Trp Ala Pro Arg Arg Val Ala Ile Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Tyr Ser His Ser Pro Gly Ala Cys His His Pro Gln Leu Ser Glu Leu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Val Lys Asn Met Leu Gln Leu Leu Ser Leu Pro Pro Phe Ser Arg Ser 
               
               
                         115                 120                 125 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 201 
               
               
                 &lt;211&gt; LENGTH: 1458 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (493) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 201 
               
               
                   
               
               
                 gggccatggt tccctgcggg cggcggggag ggatttcctg gggcgccccc tggaatccaa     60 
               
               
                   
               
               
                 gcccgaccgc agtgtctgac catggtccgc ggcgcggccg ggtggtcctg caggggccgc    120 
               
               
                   
               
               
                 gcatagctcc gactacagca tgtggaggaa gaaccagtac gtcagtaacg ggctgcgcga    180 
               
               
                   
               
               
                 ctttgcggag cgcggcgagg cctgggcgct gatgaaggag atcgaggcgg cgggggaggc    240 
               
               
                   
               
               
                 gctgcagagc gtgcacgcgg tgttttcggc gcccgccgtc cccagcggca ccgggcagac    300 
               
               
                   
               
               
                 gtcggcggag ctggaggtgc agcgcaggca ctcgctggtc tcgtttgtgg tgcgcatcgt    360 
               
               
                   
               
               
                 gcccagcccc gactggttcg tgggcgtgaa cagcctggac ctgtgcgacg gggaccgttg    420 
               
               
                   
               
               
                 gcgggaacag gcggcgctgg acctgtaccc ctacgacgcc gggacggaca gcggcttcac    480 
               
               
                   
               
               
                 cttctcctcc ccnaacttcg ccaccatccc gcaggacacg gtgaccgaga taacgtcctc    540 
               
               
                   
               
               
                 ctctcccagc cacccggcca actccttcta ctacccgcgg ctgaaggccc tgcctcccat    600 
               
               
                   
               
               
                 cgccagggtg acactggtgc ggctgcgaca gagccccagg gccttcatcc ctcccgcccc    660 
               
               
                   
               
               
                 agtcctgccc agcagggaca atgagattgt agacagcgcc tcagttccag aaacgccgct    720 
               
               
                   
               
               
                 ggactgcgag gtctccctgt ggtcgtcctg gggactgtgc ggaggcccac tgtgggaggc    780 
               
               
                   
               
               
                 tcgggaccaa gagcaggact cgctacgtcc gggtccagcc cgccaacaaa cgggagcccc    840 
               
               
                   
               
               
                 tgccccgagc tcgaagaaga ggctgagtgc gtccctgata actgcgtcta agaccagagc    900 
               
               
                   
               
               
                 cccgcagccc ctggggcccc ccggagccat ggggtgtcgg gggctcctgt gcaggctcat    960 
               
               
                   
               
               
                 gctgcaggcg gccgagggca cagggggttt cgcgctgctc ctgaccgcgg tgaggccgcg   1020 
               
               
                   
               
               
                 ccgaccatct ctgcactgaa gggccctctg gtggccggca cgggcattgg gaaacagcct   1080 
               
               
                   
               
               
                 cctcctttcc caaccttgct tcttaggggc ccccgtgtcc cgtctgctct cagcctcctc   1140 
               
               
                   
               
               
                 ctcctgcagg ataaagtcat ccccaaggct ccagctactc taaattatgt ctccttataa   1200 
               
               
                   
               
               
                 gttattgctg ctccaggaga ttgtccttca tcgtccaggg gcctggctcc cacgtggttg   1260 
               
               
                   
               
               
                 cagatacctc agacctggtg ctctaggctg tgctgagccc actctcccga gggcgcatcc   1320 
               
               
                   
               
               
                 aagcgggggc cacttgagaa gtgaataaat ggggcggttt cggaagcgtc agtgtttcca   1380 
               
               
                   
               
               
                 tgttatggat ctctctgcgt ttgaataaag actatctctg ttgctcacaa aaaaaaaaaa   1440 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaa                                                 1458 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 202 
               
               
                 &lt;211&gt; LENGTH: 299 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 202 
               
               
                   
               
               
                 Met Trp Arg Lys Asn Gln Tyr Val Ser Asn Gly Leu Arg Asp Phe Ala 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Glu Arg Gly Glu Ala Trp Ala Leu Met Lys Glu Ile Glu Ala Ala Gly 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Glu Ala Leu Gln Ser Val His Ala Val Phe Ser Ala Pro Ala Val Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ser Gly Thr Gly Gln Thr Ser Ala Glu Leu Glu Val Gln Arg Arg His 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ser Leu Val Ser Phe Val Val Arg Ile Val Pro Ser Pro Asp Trp Phe 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Val Gly Val Asn Ser Leu Asp Leu Cys Asp Gly Asp Arg Trp Arg Glu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Gln Ala Ala Leu Asp Leu Tyr Pro Tyr Asp Ala Gly Thr Asp Ser Gly 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Phe Thr Phe Ser Ser Pro Asn Phe Ala Thr Ile Pro Gln Asp Thr Val 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Thr Glu Ile Thr Ser Ser Ser Pro Ser His Pro Ala Asn Ser Phe Tyr 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Tyr Pro Arg Leu Lys Ala Leu Pro Pro Ile Ala Arg Val Thr Leu Val 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Arg Leu Arg Gln Ser Pro Arg Ala Phe Ile Pro Pro Ala Pro Val Leu 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Pro Ser Arg Asp Asn Glu Ile Val Asp Ser Ala Ser Val Pro Glu Thr 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Pro Leu Asp Cys Glu Val Ser Leu Trp Ser Ser Trp Gly Leu Cys Gly 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Gly Pro Leu Trp Glu Ala Arg Asp Gln Glu Gln Asp Ser Leu Arg Pro 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Gly Pro Ala Arg Gln Gln Thr Gly Ala Pro Ala Pro Ser Ser Lys Lys 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Arg Leu Ser Ala Ser Leu Ile Thr Ala Ser Lys Thr Arg Ala Pro Gln 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Pro Leu Gly Pro Pro Gly Ala Met Gly Cys Arg Gly Leu Leu Cys Arg 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Leu Met Leu Gln Ala Ala Glu Gly Thr Gly Gly Phe Ala Leu Leu Leu 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Thr Ala Val Arg Pro Arg Arg Pro Ser Leu His 
               
               
                     290                 295 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 203 
               
               
                 &lt;211&gt; LENGTH: 1100 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 203 
               
               
                   
               
               
                 attacaggcg tgagccatgc gtccagcagg aaaaggtttt ttaatgaacc atagagacct     60 
               
               
                   
               
               
                 ctcagagctc cagatttggg ggatggggtc agataatcag gagagttccc gaagaaagtg    120 
               
               
                   
               
               
                 ccatttgagc tgtgatctga aggaacacta gtaagtagtc agctaggcac agatggggag    180 
               
               
                   
               
               
                 aggagagggc attctgggcc gaggacacag cgtgggtgaa atcctggagg tgggaagcgg    240 
               
               
                   
               
               
                 cactgtgctc cagagggact ggaggagagc cagagtgact ggcacatcag gagggcacag    300 
               
               
                   
               
               
                 gggatgcccg agctgctggt gagacagaca ggactgagag aaacagcaag ctggtctctg    360 
               
               
                   
               
               
                 acagcttccc gtcaagtggt gatctgtctc ccttcgtcct cccctgccct cccactatct    420 
               
               
                   
               
               
                 ctgttttccc cagtgccctt tctttccttt ccctgttctt ccttttggaa gaacatacga    480 
               
               
                   
               
               
                 gctcacctgt gttctggttc cttttctaaa gggctttatg attacttaac caacctcata    540 
               
               
                   
               
               
                 accatggacc agccaacatt tcacaaatac tcactcaaaa caagcctgtt attatcaccc    600 
               
               
                   
               
               
                 tcgtttcaca gaagtggaaa ctggggtgca gaaagatgaa gggtcagcag ctggtcagtg    660 
               
               
                   
               
               
                 acgagccagg gtccaaggcc aggatgtctg cccagccgcc atgctcactg cctttcatct    720 
               
               
                   
               
               
                 tggttctcct aggaagagtt agttacttct agggtattat tagattggtg caaaagtaat    780 
               
               
                   
               
               
                 tgtgggtttt gccattgaaa ataattactt ctacaccaac ctaatacttt tttcccaagg    840 
               
               
                   
               
               
                 ggtttagtag aaggattcct gcagaccaga aacccagagg gatattgctg atgtggtagg    900 
               
               
                   
               
               
                 tgttgggcca gcagggagag aggtctgagc ccctgccagg tgctacctgg gagccacttt    960 
               
               
                   
               
               
                 gtcagcattt gtttgttcta cttgggaggt agccctgcca gggacacctg gggacacctt   1020 
               
               
                   
               
               
                 ttcccactgg aagcgccatc tgaatccaga accgttttct ttgtcttaag aaaaaaaaaa   1080 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaaaaa                                               1100 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 204 
               
               
                 &lt;211&gt; LENGTH: 111 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 204 
               
               
                   
               
               
                 Met Pro Glu Leu Leu Val Arg Gln Thr Gly Leu Arg Glu Thr Ala Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Trp Ser Leu Thr Ala Ser Arg Gln Val Val Ile Cys Leu Pro Ser Ser 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ser Pro Ala Leu Pro Leu Ser Leu Phe Ser Pro Val Pro Phe Leu Ser 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Phe Pro Cys Ser Ser Phe Trp Lys Asn Ile Arg Ala His Leu Cys Ser 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gly Ser Phe Ser Lys Gly Leu Tyr Asp Tyr Leu Thr Asn Leu Ile Thr 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Met Asp Gln Pro Thr Phe His Lys Tyr Ser Leu Lys Thr Ser Leu Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Leu Ser Pro Ser Phe His Arg Ser Gly Asn Trp Gly Ala Glu Arg 
               
               
                             100                 105                 110 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 205 
               
               
                 &lt;211&gt; LENGTH: 1395 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 205 
               
               
                   
               
               
                 ttcaagacca gcctgaccaa catggagaaa ccctgtctct actaaaaata caaaattagc     60 
               
               
                   
               
               
                 cgggcatggt ggcaatgcct gcctgtaatc ccagctactc gggaggctga ggcaaaagaa    120 
               
               
                   
               
               
                 tcgcttgaac ccaggaggca gaggttgcag tgagctgaga ttgtgctatt gcactccagc    180 
               
               
                   
               
               
                 ctggataaca agagcgagac tccgtctcaa aaaaaaaaaa aaatttgtag agatagtgtt    240 
               
               
                   
               
               
                 ttgctacgtt actcagggtg gtctcaaact cctggcctca ggcagttctg cctaggcttc    300 
               
               
                   
               
               
                 ccaaagtact gggattacag gcagaagcca ctgcgcctac catagaatat tagttatctt    360 
               
               
                   
               
               
                 ttgaagtgat taaaaaggga aaagattttc ttccaagttt aatgatgaga aaagtgaaag    420 
               
               
                   
               
               
                 aacagttatt ttaaagcccc tgatatttcc aacatctagg tcataaatga gtctcgttct    480 
               
               
                   
               
               
                 gttgatagct ttatctcttg gtaatgtgca tgcctgtgtg tgtgtgtgtg tgtgtgttct    540 
               
               
                   
               
               
                 attctgtgat gtcttataat ttttagttta atggcaaaca tcatgtatac aagaccagta    600 
               
               
                   
               
               
                 gagactgagg tagatggtat tctgtgtctg gatataggca cgcctctccc atcaggccaa    660 
               
               
                   
               
               
                 ttgcctgtga cattgagtca acctagtctg gagttgaggt ggatttggat tttgatgttg    720 
               
               
                   
               
               
                 gtatcattat gttcagtgta cttgggctgc tgttacctgg tacctggagc ctggggtacc    780 
               
               
                   
               
               
                 agatggtttt tcttcagtgt ttctgttcca ctgttggctt tcctcagtcc catcatgcct    840 
               
               
                   
               
               
                 ccatcacaga gggggagtct ctattcatat ccttgcccct tcactagtgg ttgactgatg    900 
               
               
                   
               
               
                 ctgcttgtta ctcagtgcta ggcttatggt ggtgtcatag gtggttttct attgtcctgg    960 
               
               
                   
               
               
                 ttcagcctta gctttaggca gtccctgttc atttgaaccc caggggtggt acttaatctg   1020 
               
               
                   
               
               
                 ccctttcctg agcagtagca aacctctgct tggcatcaga ttcttgggcc aatgaggatt   1080 
               
               
                   
               
               
                 ctctcctgct ctcccagaaa caagatgttt gcttctacct ctcccccagc agcaataggg   1140 
               
               
                   
               
               
                 tatgtgagag gtgggaggtt tacttgaacc caggaggtcg aggctgcagt gagccatgat   1200 
               
               
                   
               
               
                 agtggcacca cactccagcc tgggtgacag agcaagaccc tgtctcaaaa caacaacaac   1260 
               
               
                   
               
               
                 aacccaaaaa actgtcaagg tcatcaggaa caaaacatag ccaatagcca agaaactgtc   1320 
               
               
                   
               
               
                 acataccaga ggagactaag gaaacatgat gactaaatgc aatacaaaaa aaaaaaaaaa   1380 
               
               
                   
               
               
                 aaaaaaaaaa aaaaa                                                    1395 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 206 
               
               
                 &lt;211&gt; LENGTH: 107 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 206 
               
               
                   
               
               
                 Met Ala Asn Ile Met Tyr Thr Arg Pro Val Glu Thr Glu Val Asp Gly 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ile Leu Cys Leu Asp Ile Gly Thr Pro Leu Pro Ser Gly Gln Leu Pro 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Val Thr Leu Ser Gln Pro Ser Leu Glu Leu Arg Trp Ile Trp Ile Leu 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Met Leu Val Ser Leu Cys Ser Val Tyr Leu Gly Cys Cys Tyr Leu Val 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Pro Gly Ala Trp Gly Thr Arg Trp Phe Phe Phe Ser Val Ser Val Pro 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Leu Ala Phe Leu Ser Pro Ile Met Pro Pro Ser Gln Arg Gly Ser 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Leu Tyr Ser Tyr Pro Cys Pro Phe Thr Ser Gly 
               
               
                             100                 105 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 207 
               
               
                 &lt;211&gt; LENGTH: 1617 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 207 
               
               
                   
               
               
                 tccacttatt ctggatattc ttactattca agtcattcga aaaaatctca cagacaaggg     60 
               
               
                   
               
               
                 gaaagaacta gagagagaca caagtcaccc cggaataaag acggcagagg gtcagaaaag    120 
               
               
                   
               
               
                 tctgtcacca ttcaacctcc cactggagag cccctgttgg gaaatgattc tactcggaca    180 
               
               
                   
               
               
                 gaggaagttc aggatgacaa ctggggagag accaccacgg ccatcacagg cacctcggag    240 
               
               
                   
               
               
                 cacagcatat cccaagagga cattgccagg atcagcaagg acatggagga cagcgtgggg    300 
               
               
                   
               
               
                 ctggattgca aacgctacct gggcctcacc gtcgcctctt ttcttggact tctagttttc    360 
               
               
                   
               
               
                 ctcaccccta ttgccttcat ccttttacct ccgatcctgt ggagggatga gctggagcct    420 
               
               
                   
               
               
                 tgtggcacaa tttgtgaggg gctctttatc tccatggcat tcaaactcct cattctgctc    480 
               
               
                   
               
               
                 atagggacct gggcactttt tttccgcaag cggagagctg acatgccacg ggtgtttgtg    540 
               
               
                   
               
               
                 tttcgtgccc ttttgttggt cctcattttt ctctttgtgg tttcctattg gcttttttac    600 
               
               
                   
               
               
                 ggggtccgca ttttggactc tcgggaccgg aattaccagg gcattgtgca atatgcagtc    660 
               
               
                   
               
               
                 tcccttgtgg atgccctcct cttcatccat tacctggcca tcgtcctgct ggagctcagg    720 
               
               
                   
               
               
                 cagctgcagc ccatgttcac gctgcaggtg gtccgctcca ccgatggcga gtcccgcttc    780 
               
               
                   
               
               
                 tacagcctgg gacacctgag tatccagcga gcagcattgg tggtcctaga aaattactac    840 
               
               
                   
               
               
                 aaagatttca ccatctataa cccaaacctc ctaacagcct ccaaattccg agcagccaag    900 
               
               
                   
               
               
                 catatggccg ggctgaaagt ctacaatgta gatggcccca gtaacaatgc cactggccag    960 
               
               
                   
               
               
                 tcccgggcca tgattgctgc agctgctcgg cgcagggact caagccacaa cgagttgtat   1020 
               
               
                   
               
               
                 tatgaagagg ccgaacatga acggcgagta aagaagcgga aagcaaggct ggtggttgca   1080 
               
               
                   
               
               
                 gtggaagagg ccttcatcca cattcagcgt ctccaggctg aggagcagca gaaagcccca   1140 
               
               
                   
               
               
                 ggggaggtga tggaccctag ggaggccgcc caggccattt tcccctccat ggccagggct   1200 
               
               
                   
               
               
                 ctccagaagt acctgcgcat cacccggcag cagaactacc acagcatgga gagcatcctg   1260 
               
               
                   
               
               
                 cagcacctgg ccttctgcat caccaacggc atgaccccca aggccttcct agaacggtac   1320 
               
               
                   
               
               
                 ctcagtgcgg gccccaccct gcaatatgac aaggaccgct ggctctctac acagtggagg   1380 
               
               
                   
               
               
                 cttgtcagtg atgaggctgt gactaatgga ttacgggatg gaattgtgtt cgtccttaag   1440 
               
               
                   
               
               
                 tgcttggact tcagcctcgt agtcaatgtg aagaaaattc cattcatcat actctctgaa   1500 
               
               
                   
               
               
                 gagttcatag accccaaatc tcacaaattt gtccttcgct tacagtctga gacatccgtt   1560 
               
               
                   
               
               
                 taaaagttct atatttgtgg ctttattaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa      1617 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 208 
               
               
                 &lt;211&gt; LENGTH: 426 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 208 
               
               
                   
               
               
                 Met Glu Asp Ser Val Gly Leu Asp Cys Lys Arg Tyr Leu Gly Leu Thr 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Val Ala Ser Phe Leu Gly Leu Leu Val Phe Leu Thr Pro Ile Ala Phe 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ile Leu Leu Pro Pro Ile Leu Trp Arg Asp Glu Leu Glu Pro Cys Gly 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Thr Ile Cys Glu Gly Leu Phe Ile Ser Met Ala Phe Lys Leu Leu Ile 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Leu Ile Gly Thr Trp Ala Leu Phe Phe Arg Lys Arg Arg Ala Asp 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Met Pro Arg Val Phe Val Phe Arg Ala Leu Leu Leu Val Leu Ile Phe 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Leu Phe Val Val Ser Tyr Trp Leu Phe Tyr Gly Val Arg Ile Leu Asp 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ser Arg Asp Arg Asn Tyr Gln Gly Ile Val Gln Tyr Ala Val Ser Leu 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Val Asp Ala Leu Leu Phe Ile His Tyr Leu Ala Ile Val Leu Leu Glu 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Leu Arg Gln Leu Gln Pro Met Phe Thr Leu Gln Val Val Arg Ser Thr 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Asp Gly Glu Ser Arg Phe Tyr Ser Leu Gly His Leu Ser Ile Gln Arg 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Ala Ala Leu Val Val Leu Glu Asn Tyr Tyr Lys Asp Phe Thr Ile Tyr 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Asn Pro Asn Leu Leu Thr Ala Ser Lys Phe Arg Ala Ala Lys His Met 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Ala Gly Leu Lys Val Tyr Asn Val Asp Gly Pro Ser Asn Asn Ala Thr 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Gly Gln Ser Arg Ala Met Ile Ala Ala Ala Ala Arg Arg Arg Asp Ser 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Ser His Asn Glu Leu Tyr Tyr Glu Glu Ala Glu His Glu Arg Arg Val 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Lys Lys Arg Lys Ala Arg Leu Val Val Ala Val Glu Glu Ala Phe Ile 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 His Ile Gln Arg Leu Gln Ala Glu Glu Gln Gln Lys Ala Pro Gly Glu 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Val Met Asp Pro Arg Glu Ala Ala Gln Ala Ile Phe Pro Ser Met Ala 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Arg Ala Leu Gln Lys Tyr Leu Arg Ile Thr Arg Gln Gln Asn Tyr His 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Ser Met Glu Ser Ile Leu Gln His Leu Ala Phe Cys Ile Thr Asn Gly 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Met Thr Pro Lys Ala Phe Leu Glu Arg Tyr Leu Ser Ala Gly Pro Thr 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Leu Gln Tyr Asp Lys Asp Arg Trp Leu Ser Thr Gln Trp Arg Leu Val 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 Ser Asp Glu Ala Val Thr Asn Gly Leu Arg Asp Gly Ile Val Phe Val 
               
               
                     370                 375                 380 
               
               
                   
               
               
                 Leu Lys Cys Leu Asp Phe Ser Leu Val Val Asn Val Lys Lys Ile Pro 
               
               
                 385                 390                 395                 400 
               
               
                   
               
               
                 Phe Ile Ile Leu Ser Glu Glu Phe Ile Asp Pro Lys Ser His Lys Phe 
               
               
                                 405                 410                 415 
               
               
                   
               
               
                 Val Leu Arg Leu Gln Ser Glu Thr Ser Val 
               
               
                             420                 425 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 209 
               
               
                 &lt;211&gt; LENGTH: 2259 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (2194) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 209 
               
               
                   
               
               
                 ccaaagaggc ctagacactt tgggggtgca ctggcacttt gcagggttca ctggcacttt     60 
               
               
                   
               
               
                 ctggggctca ttgacacttt ggggtacact ggcattcttt ggtgttcact ggcattttgg    120 
               
               
                   
               
               
                 gggtgcactg gcactttgga acaacggcac gcctcttggc ccttgcccag ctggtgctcc    180 
               
               
                   
               
               
                 tggctgggaa gctgaacaca ctggctgctg tggtcactgt cttctacctg gtggcctatg    240 
               
               
                   
               
               
                 ctgccgtgga cctgtcctgc ctgagcctgg agtgggcctc ggccccaact tccggtgaga    300 
               
               
                   
               
               
                 gactcagatc tgtgtcccca gagagaagaa gggaggactc gggctcaggc gtggggctgg    360 
               
               
                   
               
               
                 ggactgcagc ctcgtgtgcg gcctgccctg agtttctgtc cctcctcccc tccatgcccg    420 
               
               
                   
               
               
                 tagccccacc ttcagcctgt tctcctggca cacctgcctg ctgggggtgg cctcctgcct    480 
               
               
                   
               
               
                 gctcatgatg ttcctcatca gtcctggcgc ggctggtggc tccctgctcc tcatgggtct    540 
               
               
                   
               
               
                 gctggctgcc ctgctcaccg cgcgaggagg ccccagtagc tggggctatg tcagccaggc    600 
               
               
                   
               
               
                 cttgcttttc caccaggtgc gtaagtatct gcttcggctg gacgtccgga aggatcacgt    660 
               
               
                   
               
               
                 gaagttctgg cggccccagc tgctgctcct ggtggggaac ccccggggcg ccctgcctct    720 
               
               
                   
               
               
                 gctgcggttg gccaaccagc ttaagaaggg ggggctgtat gtgctgggcc acgtcaccct    780 
               
               
                   
               
               
                 gggagacctc gactccctgc cctcggaccc tgtacagccg cagtatgggg catggctcag    840 
               
               
                   
               
               
                 cctggtggac cgtgcccagg tgaaggcttt tgtggatcta accctctcac cctccgtgcg    900 
               
               
                   
               
               
                 ccagggggct cagcatctgc tgcgaatctc cggcctcggt ggcatgaagc ccaacacgtt    960 
               
               
                   
               
               
                 ggtcctaggt ttctacgatg acgctccacc gcaggaccat ttcctgacgg acccggcttt   1020 
               
               
                   
               
               
                 ctctgagcct gcagacagca ccagggaggg cagttcccca gctctgagca ccctgttccc   1080 
               
               
                   
               
               
                 tcctccccgg gctcctggga gcccccgggc cctcaatccc caggactatg tggccacggt   1140 
               
               
                   
               
               
                 ggccgacgcc ctcaagatga acaagaatgt ggtgctggcc cgggccagcg gggccttgcc   1200 
               
               
                   
               
               
                 ccctgagcgg ctgagccggg ggtctggggg cacctctcag ctgcaccatg tggacgtgtg   1260 
               
               
                   
               
               
                 gccctcaacc tgctgcggcc ccggggtggg cccggctatg tggatgtctg cggcctcttc   1320 
               
               
                   
               
               
                 ctgctgcaga tggcaaccat cttgggcatg gtgcccgctt ggcatagcgc ccggctccgg   1380 
               
               
                   
               
               
                 atcttcctgt gcctggggcc tcgggaggcg cctggggcgg ccgagggcgg ctgcgggcac   1440 
               
               
                   
               
               
                 tgctgagcca actgaggatc cgggctgagg tgcagaaggt ggtgtggggc gagggggccg   1500 
               
               
                   
               
               
                 gggctgggga acccgaggcg gaggaggaag gggactttgt gaacagtggg cggggagacg   1560 
               
               
                   
               
               
                 cagaggcaga ggccctggca cgcagcgcca acgccctggt tcgggcccag caggggcgcg   1620 
               
               
                   
               
               
                 gcacaggagg agggccgggt gggccggagg gtggggatgc tgagggcccc atcacagccc   1680 
               
               
                   
               
               
                 tcaccttcct gtacttgcct cggccgccag ccgatcccgc ccgatacccc cgctacctgg   1740 
               
               
                   
               
               
                 cgctactgga gactctaacc cgagacctgg gccccacgct gctggttcat ggggtcactc   1800 
               
               
                   
               
               
                 cagtcacctg cactgatctg tgatgcccct gcctccaggg ctaggtagag agggcccagg   1860 
               
               
                   
               
               
                 caggcggcct atcctgatcc ttggaggagg tggaagagga ggccactgtg gcccgtggcc   1920 
               
               
                   
               
               
                 ctgcccttgg gacgtggagc ccaggggagg tttgaagggg atcctgggct tgggcatcac   1980 
               
               
                   
               
               
                 gcccacctcc tttggcagag ggaccccagc acactaactc tgggtggctg tccccaccgt   2040 
               
               
                   
               
               
                 gcgggggggg gagtccgcag cctcccttca ctggtgcctt gatgctgggg gccaggcctc   2100 
               
               
                   
               
               
                 ctctgtgact ctgggctccc tcagtttccc cattttggcc agactcaccg gcccactggg   2160 
               
               
                   
               
               
                 gtggtgatgt tttcgttctg ttttattttt ctanctctgc tgaccatgaa taaaagacca   2220 
               
               
                   
               
               
                 aaacactatt aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                          2259 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 210 
               
               
                 &lt;211&gt; LENGTH: 327 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 210 
               
               
                   
               
               
                 Met Met Phe Leu Ile Ser Pro Gly Ala Ala Gly Gly Ser Leu Leu Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Met Gly Leu Leu Ala Ala Leu Leu Thr Ala Arg Gly Gly Pro Ser Ser 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Trp Gly Tyr Val Ser Gln Ala Leu Leu Phe His Gln Val Arg Lys Tyr 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Leu Leu Arg Leu Asp Val Arg Lys Asp His Val Lys Phe Trp Arg Pro 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gln Leu Leu Leu Leu Val Gly Asn Pro Arg Gly Ala Leu Pro Leu Leu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Arg Leu Ala Asn Gln Leu Lys Lys Gly Gly Leu Tyr Val Leu Gly His 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Val Thr Leu Gly Asp Leu Asp Ser Leu Pro Ser Asp Pro Val Gln Pro 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Gln Tyr Gly Ala Trp Leu Ser Leu Val Asp Arg Ala Gln Val Lys Ala 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Phe Val Asp Leu Thr Leu Ser Pro Ser Val Arg Gln Gly Ala Gln His 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Leu Leu Arg Ile Ser Gly Leu Gly Gly Met Lys Pro Asn Thr Leu Val 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Leu Gly Phe Tyr Asp Asp Ala Pro Pro Gln Asp His Phe Leu Thr Asp 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Pro Ala Phe Ser Glu Pro Ala Asp Ser Thr Arg Glu Gly Ser Ser Pro 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Ala Leu Ser Thr Leu Phe Pro Pro Pro Arg Ala Pro Gly Ser Pro Arg 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Ala Leu Asn Pro Gln Asp Tyr Val Ala Thr Val Ala Asp Ala Leu Lys 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Met Asn Lys Asn Val Val Leu Ala Arg Ala Ser Gly Ala Leu Pro Pro 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Glu Arg Leu Ser Arg Gly Ser Gly Gly Thr Ser Gln Leu His His Val 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Asp Val Trp Pro Ser Thr Cys Cys Gly Pro Gly Val Gly Pro Ala Met 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Trp Met Ser Ala Ala Ser Ser Cys Cys Arg Trp Gln Pro Ser Trp Ala 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Trp Cys Pro Leu Gly Ile Ala Pro Gly Ser Gly Ser Ser Cys Ala Trp 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Gly Leu Gly Arg Arg Leu Gly Arg Pro Arg Ala Ala Ala Gly Thr Ala 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Glu Pro Thr Glu Asp Pro Gly 
               
               
                                 325 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 211 
               
               
                 &lt;211&gt; LENGTH: 1001 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (812) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 211 
               
               
                   
               
               
                 gaaaccgttg atgggactga gaaaccagag ttaaaacctc tttggagctt ctgaggactc     60 
               
               
                   
               
               
                 agctggaacc aacgggcaca gttggcaaca ccatcatgac atcacaacct gttcccaatg    120 
               
               
                   
               
               
                 agaccatcat agtgctccca tcaaatgtca tcaacttctc ccaagcagag aaacccgaac    180 
               
               
                   
               
               
                 ccaccaacca ggggcaggat agcctgaaga aacatctaca cgcagaaatc aaagttattg    240 
               
               
                   
               
               
                 ggactatcca gatcttgtgt ggcatgatgg tattgagctt ggggatcatt ttggcatctg    300 
               
               
                   
               
               
                 cttccttctc tccaaatttt acccaagtga cttctacact gttgaactct gcttacccat    360 
               
               
                   
               
               
                 tcataggacc cttttttttt atcatctctg gctctctatc aatcgccaca gagaaaaggt    420 
               
               
                   
               
               
                 taaccaagct tttggtgcat agcagcctgg ttggaagcat tctgagtgct ctgtctgccc    480 
               
               
                   
               
               
                 tggtgggttt cattatcctg tctgtcaaac aggccacctt aaatcctgcc tcactgcagt    540 
               
               
                   
               
               
                 gtgagttgga caaaaataat ataccaacaa gaagttatgt ttcttacttt tatcatgatt    600 
               
               
                   
               
               
                 cactttatac cacggactgc tatacagcca aagccagtct ggctggaact ctctctctga    660 
               
               
                   
               
               
                 tgctgatttg cactctgctg gaattctgcc ttgctgtgct cactgctgtg ctgcggtgga    720 
               
               
                   
               
               
                 aacaggctta ctctgacttc cctgggagtg tacttttcct gcctcacagt tacattggta    780 
               
               
                   
               
               
                 attctggcat gtcctcaaaa atgactcatg anctgtggat atgaagaact attgacttct    840 
               
               
                   
               
               
                 taagaaaaaa gggagaaata ttaatcagaa agttgattct tatgataata tggaaaagtt    900 
               
               
                   
               
               
                 aaccattata gaaaagcaaa gcttgagttt cctaaatgta agcttttaaa gtaatgaaca    960 
               
               
                   
               
               
                 ttaaaaaaaa ccattatttc actgtcaaaa aaaaaaaaaa a                       1001 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 212 
               
               
                 &lt;211&gt; LENGTH: 242 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: UNSURE 
               
               
                 &lt;222&gt; LOCATION: (239) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 212 
               
               
                   
               
               
                 Met Thr Ser Gln Pro Val Pro Asn Glu Thr Ile Ile Val Leu Pro Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Asn Val Ile Asn Phe Ser Gln Ala Glu Lys Pro Glu Pro Thr Asn Gln 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gly Gln Asp Ser Leu Lys Lys His Leu His Ala Glu Ile Lys Val Ile 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gly Thr Ile Gln Ile Leu Cys Gly Met Met Val Leu Ser Leu Gly Ile 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ile Leu Ala Ser Ala Ser Phe Ser Pro Asn Phe Thr Gln Val Thr Ser 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Thr Leu Leu Asn Ser Ala Tyr Pro Phe Ile Gly Pro Phe Phe Phe Ile 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Ile Ser Gly Ser Leu Ser Ile Ala Thr Glu Lys Arg Leu Thr Lys Leu 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Leu Val His Ser Ser Leu Val Gly Ser Ile Leu Ser Ala Leu Ser Ala 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Leu Val Gly Phe Ile Ile Leu Ser Val Lys Gln Ala Thr Leu Asn Pro 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Ala Ser Leu Gln Cys Glu Leu Asp Lys Asn Asn Ile Pro Thr Arg Ser 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Tyr Val Ser Tyr Phe Tyr His Asp Ser Leu Tyr Thr Thr Asp Cys Tyr 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Thr Ala Lys Ala Ser Leu Ala Gly Thr Leu Ser Leu Met Leu Ile Cys 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Thr Leu Leu Glu Phe Cys Leu Ala Val Leu Thr Ala Val Leu Arg Trp 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Lys Gln Ala Tyr Ser Asp Phe Pro Gly Ser Val Leu Phe Leu Pro His 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Ser Tyr Ile Gly Asn Ser Gly Met Ser Ser Lys Met Thr His Xaa Leu 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Trp Ile 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 213 
               
               
                 &lt;211&gt; LENGTH: 1079 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 213 
               
               
                   
               
               
                 gcatcctcct ctatcctgtt tcgaggtaga gagcttggca cttctgttac aagctgagag     60 
               
               
                   
               
               
                 tctggaggtg ctgagtttaa cgtggctgtg caggtgattt caaggcatga gctgaacagc    120 
               
               
                   
               
               
                 gttgacacag ccgtgactta caattaaacc ctttcaatta cagtacagat tctgtgtgct    180 
               
               
                   
               
               
                 acttgatgag atgttaccca aggccagttt ggacttactg cttttgtccc tcatattaaa    240 
               
               
                   
               
               
                 ttatcaaatg atgccgatga aatgcttgaa aatgattctg ctctcaaagt tatgcttccc    300 
               
               
                   
               
               
                 tagaaaggtg tcatgtcggg cacttgtgtt gggtgactat gacatcccag cagtgctggt    360 
               
               
                   
               
               
                 caggtctcag agttgctttc acctagagct gatgcttcca caaggggaca tttgtgttac    420 
               
               
                   
               
               
                 tttgctccag gggtctgtca taaaaacaat ggtaactact tcatccctag gaagcccaag    480 
               
               
                   
               
               
                 acttcagggc actgttagct gattggtaaa taagggacac gatattcacg ggaattgttt    540 
               
               
                   
               
               
                 actgctcccc actagtaatt ctcatggggc cactttttta actctttcta attaacacct    600 
               
               
                   
               
               
                 cttctcagca tagagcagag gatgcagtca tttctctgtt gaaatctatg tagtatttat    660 
               
               
                   
               
               
                 gtagaatgtc attatatgaa agcgaattca gaatcctaac tctgggaaag cgctctctgg    720 
               
               
                   
               
               
                 aaatgtagtt tgataatagt gtcttatagg ggccacggga atttgtttct ctataaagcg    780 
               
               
                   
               
               
                 atgggctcca gtgtcatgtt accagagtta tcgctcagtt ttgtttgtta aggcttttgc    840 
               
               
                   
               
               
                 tagaacctat tatgtatcca gtttttaaaa catacttcat tcccttgata gcagagatcc    900 
               
               
                   
               
               
                 agagcacaga tggcaagttg tgtggatgat actgaatatg tttattttcc taaagataaa    960 
               
               
                   
               
               
                 tgtcacgaca cgacatttct cagtttttat ttagatgttt attaccatgt gttaacagaa   1020 
               
               
                   
               
               
                 tcttaaaacc caagggattt cttcagtaaa ctagactttg attcaaaaaa aaaaaaaaa    1079 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 214 
               
               
                 &lt;211&gt; LENGTH: 103 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 214 
               
               
                   
               
               
                 Met Leu Pro Lys Ala Ser Leu Asp Leu Leu Leu Leu Ser Leu Ile Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Asn Tyr Gln Met Met Pro Met Lys Cys Leu Lys Met Ile Leu Leu Ser 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Lys Leu Cys Phe Pro Arg Lys Val Ser Cys Arg Ala Leu Val Leu Gly 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Asp Tyr Asp Ile Pro Ala Val Leu Val Arg Ser Gln Ser Cys Phe His 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Glu Leu Met Leu Pro Gln Gly Asp Ile Cys Val Thr Leu Leu Gln 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly Ser Val Ile Lys Thr Met Val Thr Thr Ser Ser Leu Gly Ser Pro 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Arg Leu Gln Gly Thr Val Ser 
               
               
                             100 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 215 
               
               
                 &lt;211&gt; LENGTH: 19 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 215 
               
               
                   
               
               
                 ggatggggct cattctctc                                                  19 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 216 
               
               
                 &lt;211&gt; LENGTH: 20 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 216 
               
               
                   
               
               
                 gaaatgtgta aactggcagc                                                 20 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 217 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 217 
               
               
                   
               
               
                 gaatgcagca caattagagg g                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 218 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 218 
               
               
                   
               
               
                 ctgcttagaa agcagaattg c                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 219 
               
               
                 &lt;211&gt; LENGTH: 19 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 219 
               
               
                   
               
               
                 tgtgactagc aatgtatgc                                                  19 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 220 
               
               
                 &lt;211&gt; LENGTH: 20 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 220 
               
               
                   
               
               
                 tcagaagaaa gccatagggc                                                 20 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 221 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 221 
               
               
                   
               
               
                 cctcaagatg atttgcacag c                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 222 
               
               
                 &lt;211&gt; LENGTH: 19 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 222 
               
               
                   
               
               
                 ggagagcacg ttcagaggg                                                  19 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 223 
               
               
                 &lt;211&gt; LENGTH: 20 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 223 
               
               
                   
               
               
                 gactgactct gggttcctgg                                                 20 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 224 
               
               
                 &lt;211&gt; LENGTH: 20 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 224 
               
               
                   
               
               
                 ggtagtgaag actgtgccgg                                                 20 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 225 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 225 
               
               
                   
               
               
                 ggaagtgact tccaatgatg c                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 226 
               
               
                 &lt;211&gt; LENGTH: 18 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 226 
               
               
                   
               
               
                 ctcgctggca ttggtttg                                                   18 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 227 
               
               
                 &lt;211&gt; LENGTH: 20 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 227 
               
               
                   
               
               
                 ccatgaccat agtcagtggg                                                 20 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 228 
               
               
                 &lt;211&gt; LENGTH: 20 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 228 
               
               
                   
               
               
                 aaatgtccaa tagttcctgg                                                 20 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 229 
               
               
                 &lt;211&gt; LENGTH: 19 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 229 
               
               
                   
               
               
                 ggagcaatgc tgagctacc                                                  19 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 230 
               
               
                 &lt;211&gt; LENGTH: 18 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 230 
               
               
                   
               
               
                 ctgcgacacc cttgacac                                                   18 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 231 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 231 
               
               
                   
               
               
                 tcaccaagtg tatggagaat g                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 232 
               
               
                 &lt;211&gt; LENGTH: 20 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 232 
               
               
                   
               
               
                 tatctgaacc taatggtttg                                                 20 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 233 
               
               
                 &lt;211&gt; LENGTH: 20 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 233 
               
               
                   
               
               
                 cagtcagatt tgggtcaggc                                                 20 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 234 
               
               
                 &lt;211&gt; LENGTH: 20 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 234 
               
               
                   
               
               
                 tcttacctca ggtgatccgc                                                 20 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 235 
               
               
                 &lt;211&gt; LENGTH: 18 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 235 
               
               
                   
               
               
                 gaaagccagg tcagccag                                                   18 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 236 
               
               
                 &lt;211&gt; LENGTH: 20 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 236 
               
               
                   
               
               
                 cagaggaaca cctcagaccc                                                 20 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 237 
               
               
                 &lt;211&gt; LENGTH: 18 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 237 
               
               
                   
               
               
                 ttcgtccagc agcaagtg                                                   18 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 238 
               
               
                 &lt;211&gt; LENGTH: 18 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 238 
               
               
                   
               
               
                 tatggttcgg ttgggtgg                                                   18 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 239 
               
               
                 &lt;211&gt; LENGTH: 18 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 239 
               
               
                   
               
               
                 ctacaggagg aggccgtg                                                   18 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 240 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 240 
               
               
                   
               
               
                 ccagggaaga tgagaggaga g                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 241 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 241 
               
               
                   
               
               
                 gcgaaatggt ttatttactg c                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 242 
               
               
                 &lt;211&gt; LENGTH: 18 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 242 
               
               
                   
               
               
                 cagcccttct gagtcccc                                                   18 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 243 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 243 
               
               
                   
               
               
                 tgagagtgtg tgtgctgatt c                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 244 
               
               
                 &lt;211&gt; LENGTH: 18 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 244 
               
               
                   
               
               
                 tccaccctcc ttgctctg                                                   18 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 245 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 245 
               
               
                   
               
               
                 ttctcattct caagctctgc c                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 246 
               
               
                 &lt;211&gt; LENGTH: 19 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 246 
               
               
                   
               
               
                 agaatcagag ggtcgtggg                                                  19 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 247 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 247 
               
               
                   
               
               
                 ttgaggtatg aacagggaag g                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 248 
               
               
                 &lt;211&gt; LENGTH: 20 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 248 
               
               
                   
               
               
                 ccaaatcatg gagaagatgc                                                 20 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 249 
               
               
                 &lt;211&gt; LENGTH: 20 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 249 
               
               
                   
               
               
                 gcccttgtat cttgggcttc                                                 20 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 250 
               
               
                 &lt;211&gt; LENGTH: 18 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 250 
               
               
                   
               
               
                 ctccacctct gcccgtag                                                   18 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 251 
               
               
                 &lt;211&gt; LENGTH: 20 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 251 
               
               
                   
               
               
                 tgggtacttt ctgcattggg                                                 20 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 252 
               
               
                 &lt;211&gt; LENGTH: 19 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 252 
               
               
                   
               
               
                 ggactaccct gttccccac                                                  19 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 253 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 253 
               
               
                   
               
               
                 tgagcagtga ggagagagag c                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 254 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 254 
               
               
                   
               
               
                 gcacaaccaa cagcgctccc g                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 255 
               
               
                 &lt;211&gt; LENGTH: 18 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 255 
               
               
                   
               
               
                 taacccaccc agacacgg                                                   18 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 256 
               
               
                 &lt;211&gt; LENGTH: 19 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 256 
               
               
                   
               
               
                 tgtctcagga ggcagaagg                                                  19 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 257 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 257 
               
               
                   
               
               
                 aacaacatct gcatgtatcc c                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 258 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 258 
               
               
                   
               
               
                 agcttatcca gaccttgctt c                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 259 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 259 
               
               
                   
               
               
                 gtgttcttaa acacttgcat g                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 260 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 260 
               
               
                   
               
               
                 tgtggataca tataggaagt g                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 261 
               
               
                 &lt;211&gt; LENGTH: 19 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 261 
               
               
                   
               
               
                 gttctcactc caggttgcg                                                  19 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 262 
               
               
                 &lt;211&gt; LENGTH: 21 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 262 
               
               
                   
               
               
                 tgatgagaaa agtgaaagaa c                                               21 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 263 
               
               
                 &lt;211&gt; LENGTH: 19 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 263 
               
               
                   
               
               
                 ctgtgtagag agccagcgg                                                  19 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 264 
               
               
                 &lt;211&gt; LENGTH: 18 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Artificial Sequence 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;223&gt; OTHER INFORMATION: oligonucleotide 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 264 
               
               
                   
               
               
                 gcctcctctt ccacctcc                                                   18 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 265 
               
               
                 &lt;211&gt; LENGTH: 113 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 265 
               
               
                   
               
               
                 Met Ser Arg Pro Leu Leu Glu Arg Pro Ser Tyr Ser Leu Glu Glu Ser 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ser Pro Ala Ala Gly Phe Arg Asn Val Cys Ser Lys Leu Val Pro Ala 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 His Leu Lys Gln Ser Ser Glu Lys Val Cys Arg Asn Leu Pro Leu Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Ser Pro Ser Ser Cys Val Ala Phe Val Thr Ser Phe Leu Gln Gly Ser 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ser Gly Gly Gly Ser Arg Glu Ala Ala Thr Trp Leu Cys Met Trp Glu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ser Pro Ala Ser Ser Leu His Pro His Ser Arg Thr Ala Lys Leu Gly 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Phe Phe His Glu Glu Ala Thr Leu Met Ser Ser Leu Val Gln Leu Ser 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Gly 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 266 
               
               
                 &lt;211&gt; LENGTH: 85 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 266 
               
               
                   
               
               
                 Met Ser Ser Gly Phe Leu His Thr Ser Phe Ser Trp Val Arg Leu Ala 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Val Gln Ser Gly Cys Gly Gly Gly Leu Arg Arg Lys Gly His Trp Ser 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Ser Pro Arg Phe Gly Leu Arg Gln Val His Ser Arg Tyr His Pro Thr 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Phe Leu Ser Lys Glu Gln Ala Ser His Thr Tyr Asn Pro Phe Pro Thr 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Leu Leu Met Tyr Pro Leu Cys Gly Thr Ser Asn Gly Gly Gln Ala Asp 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Leu Pro Pro Ala Ile 
               
               
                                  85 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 267 
               
               
                 &lt;211&gt; LENGTH: 88 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 267 
               
               
                   
               
               
                 Met Leu Leu Gln Ala Ser Thr Cys Asn Met Leu Thr Tyr Lys Ser Lys 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Ile Ser Asp Gln Val Ala Gly Thr Ala Gly Ala Cys Gln Ala Ser Gly 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Tyr Leu His Asp Ser Phe Pro Cys Gly Tyr Gly Arg Ala Trp Pro Phe 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gln Gly Ser Gln Thr Ser Tyr Thr Lys Ala Gly Leu Pro Gln Ser Gly 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Tyr Phe Lys Gly Gly Lys Gln Lys Lys Gln His Met Tyr Asn Trp Lys 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Pro Gly Gly Gly Lys Arg Gly Gln 
               
               
                                  85 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 268 
               
               
                 &lt;211&gt; LENGTH: 59 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 268 
               
               
                   
               
               
                 Met Leu Gly Pro Gly Leu Cys Leu Ser Phe Gly Tyr Pro Gly Ala Ala 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Pro Ala Ala Gly Pro Ala Gly Pro Gly Thr Pro Gly Pro Gly Glu Thr 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Pro His Arg Gly Asp Pro Arg Arg Thr His Ser Val Pro Ala Ala Ala 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Glu Ala Gln Ala Leu Gly Gly Arg Gly Phe Gly 
               
               
                      50                  55