Patent Publication Number: US-2012034613-A1

Title: Apparatus and Method for Testing Relationships Between Gene Expression and Physical Appearance of Skin

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application claims priority to U.S. Provisional Application No. 61/370,190 filed Aug. 3, 2010, entitled “Apparatus and Method for Testing Relationships Between Gene Expression and Physical Appearance of Skin,” the entire content of which is hereby incorporated herein by reference in its entirety. 
    
    
     FIELD 
     The present disclosure relates to apparatus and methods for testing to identify and select genes associated with certain physical attributes of skin and methods of assessing the efficacy of a skin anti-aging agent. 
     BACKGROUND 
     The sequencing of the human genome and the continual development of analytical methods to quickly and inexpensively measure whole-genome gene expression changes has created an overload of information and a need for methods to organize, focus and reduce the data resulting from gene level analyses of biological processes. 
     Analysis of the biological process of aging may be performed at the genomic level. Skin is the largest organ of the human body. The skin aging process is influenced by many different extrinsic (e.g., environmental) or intrinsic (including genetic and biochemical pathway) factors. 
     However, examining all the changes at the human genome or genomic product level can be overwhelming, particularly when strategies of anti-aging are examined. In skin, there are thousands of changes in gene expression with chronological aging and photo-aging (Robinson et al., Genomic-driven insights into changes in aging skin,  J. Drugs Dermatol.,  2009, 8(7 Suppl):s8-11). Not only does genome-wide testing produce massive data sets, the literature reporting on genetic research is also constantly growing, making it difficult to bring together all desired knowledge and test results. 
     Focusing research resources on a smaller group of genes and/or associated proteins, and the biochemical pathways associated with the groups of genes and/or proteins may be used to reduce confusion and distraction from the many unknown or irrelevant factors and variables. In addition, there is a cost to including genes in an analysis. If fewer genes are analyzed due to a better focus, the costs of research are reduced. 
     On the other hand, for an organ as complex as skin and a problem such as aging that has multiple dimensions, too narrow a focus also may be problematic, by excluding genetic pathways that play a role in skin aging. An approach including an overall strategy to slow down physical manifestations of the aging process in skin by examining at the gene level several mechanisms of aging simultaneously may be used, instead of in-depth analysis of each individual gene. 
     The present disclosure has been developed against this backdrop. 
     SUMMARY 
     In a first aspect, the present disclosure is directed to a method of testing to identify genes associated with one or more physical attributes of skin aging. The methods comprise exposing a first sample of human skin cells or tissue to an agent, determining a first set of expression levels of a plurality of genes in the first sample of human skin, comparing the first set of expression levels to a second set of expression levels, the second set of expression levels corresponding to expression levels of human skin tissue not exposed to the agent, to identify a first subset of genes having a fold change difference in expression level between the exposed and unexposed samples that meets a first, selected biological relevance level, selecting from the first subset of genes a second subset of genes, each gene being associated with a biochemical pathway associated with physical appearance of skin aging, selecting from the second subset of genes, at least one skin attribute subset of genes, each gene in the skin attribute subset being associated with a biochemical pathway relating to the skin attribute that is shown in the comparing step to have been regulated in a more youthful direction for that biochemical pathway and skin attribute, exposing a second sample of human skin tissue to the agent, determining the levels of expression for the at least one skin attribute subset of genes in the second sample of human skin tissue using a method for determining expression levels that is different than that used for the first sample of human skin tissue, and selecting a third subset of genes from the at least one skin attribute subset of genes whose expression levels in the second sample of human skin tissue meet a second, selected biological relevance level and whose direction of regulation conforms to the more youthful direction used in selecting the at least one skin attribute subset of genes. 
     In some embodiments the biochemical pathway associated with the physical appearance of skin aging comprises at least one of skin structural protein synthesis, skin structural degradation and maintenance, extracellular matrix assembly, cellular differentiation, skin barrier component synthesis, skin barrier integrity, water regulation, or regulation of melanin production and control. 
     In some embodiments, the skin attribute for the at least one skin attribute subset of genes is skin structure, skin pigmentation, skin hydration or cell turnover. 
     In another embodiment, the first, selected biological relevance level is about a two fold difference between the exposed and unexposed samples. 
     In some embodiments, the human skin tissue comprises skin cells comprising at least one of keratinocytes, fibroblasts, adipocytes, melanocytes or combinations thereof. 
     In another embodiment, the first set of expression levels of a plurality of gene comprises expression levels for essentially the full human genome. 
     In other embodiments, the method of determining expression levels that is different than that used for the first sample of human tissue is a method using an RNA quantification metric. 
     In some embodiments, in the step of selecting from the second subset of genes, at least one skin attribute subset of genes, each gene in the skin attribute subset being associated with a biochemical pathway relating to the skin attribute that is shown in the comparing step to have been regulated in a more youthful direction for that biochemical pathway and skin attribute comprising performing this step for a plurality of skin attribute subsets of genes, and the step selecting a third subset of genes from the at least one skin attribute subset of genes whose expression levels in the second sample of human skin tissue meet a second, selected biological relevance level and whose direction of regulation conforms to the more youthful direction used in selecting the at least one skin attribute subset of genes comprising performing this step for a plurality of skin attribute subsets of genes. 
     In another embodiment, the plurality of skin attribute subsets of genes are two or more skin attribute subset of genes selected from the group consisting of skin structure, skin pigmentation, skin hydration and cell turnover. 
     In other embodiments, the method further comprises determining the levels of expression for additional genes associated with a biochemical pathway associated with skin aging in the second sample of human skin tissue using a method for determining expression levels that is different than that used for the first sample of human tissue, and selecting for the third subset of genes those genes from the additional genes associated with a biochemical pathway associated with skin aging whose expression levels in the second sample of human skin tissue meet a second, selected biological relevance level and whose direction of regulation conforms to the more youthful direction of regulation of the associated biochemical pathway. 
     In a second aspect, a computer based system of testing to identify genes associated with one or more physical attributes of skin aging comprises a first instrument for exposing a first sample of human skin tissue to an agent and determining a first set of expression levels of a plurality of genes in the first sample of human skin, a computer module for comparing the first set of expression levels to a second set of expression levels, the second set of expression levels corresponding to expression levels of human skin tissue not exposed to the agent to identify a first subset of genes having a fold change difference in expression level between the exposed and unexposed samples that meet a first, selected biological relevance level, a computer module for accessing a stored data set identifying genes, each gene being associated with a biochemical pathway associated with physical appearance of skin aging and for selecting from the first subset a second subset comprising those genes also in the second subset, a computer module for selecting from the second subset of genes, at least one skin attribute subset of genes, each gene in the skin attribute subset being associated with a biochemical pathway relating to the skin attribute that is shown in the comparing step to have been regulated in a more youthful direction for that biochemical pathway and skin attribute, a second instrument for exposing a second sample of human skin tissue to the agent and for determining the levels of expression for the at least one skin attribute subset of genes in the second sample of human skin tissue using a method for determining expression levels that is different than that used for the first sample of human tissue, a computer module for selecting a third subset of genes from the at least one skin attribute subset of genes whose expression levels in the second sample of human skin tissue meet a second, selected biological relevance level and whose direction of regulation conforms to the more youthful direction used in selecting the at least one skin attribute subset of genes. 
     In some embodiments in the system, the skin attribute for the at least one skin attribute subset of genes is skin structure, skin pigmentation, skin hydration or cell turnover. In another embodiment in the system, the first, selected biological relevance level is about a two fold difference between the exposed and unexposed samples. 
     In other embodiments in the system, the human skin tissue comprises skin cells comprising at least one of keratinocytes, fibroblasts, adipocytes, melanocytes or combinations thereof. 
     In some embodiments in the system the first set of expression levels of a plurality of genes comprises expression levels for essentially the full human genome. 
     In another embodiment in the system, the second instrument for determining expression levels that is different than that used for the first sample of human tissue is an instrument using an RNA quantification metric. 
     In a third aspect, methods of assessing the efficacy of a skin anti-aging agent are disclosed. The methods comprise exposing a first sample of human skin tissue to an agent, determining a first set of expression levels of a plurality of genes in the first sample of human skin, comparing the first set of expression levels to a second set of expression levels, the second set of expression levels corresponding to expression levels of human skin tissue not exposed to the agent, to identify a first subset of genes having a fold change difference in expression level between the exposed and unexposed samples that meets a first, selected biological relevance level, selecting from the first subset of genes a second subset of genes, each gene being associated with a biochemical pathway associated with physical appearance of skin aging, selecting from the second subset of genes, at least one skin attribute subset of genes, each gene in the skin attribute subset being associated with a biochemical pathway relating to the skin attribute that is shown in the comparing step to have been regulated in a more youthful direction for that biochemical pathway and skin attribute, exposing a second sample of human skin tissue to the agent, determining the levels of expression for the at least one skin attribute subset of genes in the second sample of human skin tissue using a method for determining expression levels that is different than that used for the first sample of human skin tissue, selecting a third subset of genes from the at least one skin attribute subset of genes whose expression levels in the second sample of human skin tissue meet a second, selected biological relevance level and whose direction of regulation conforms to the more youthful direction used in selecting the at least one skin attribute subset of genes, and comparing the third subset of genes to a previously determined third subset of genes for a second agent, thereby showing the efficacy of the skin anti-aging agent. 
     In some embodiments of the method, the skin attribute for the at least one skin attribute subset of genes is skin structure, skin pigmentation, skin hydration or cell turnover. 
     In another embodiment, the method for determining expression levels that is different than that used for the first sample of human tissue is a method using an RNA quantification metric. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       Those skilled in the art will understand that the drawings, described herein, are for illustration purposes only. The drawings are not intended to limit the scope of the present disclosure. 
         FIGS. 1A-1K  are a flowchart schematically showing, in a simplified example, steps in a process for choosing genes for inclusion in a functional youth gene assembly. 
         FIG. 2  depicts percent of change over time for different sub-categories of wrinkles, including crow&#39;s feet, under eye, and cheek areas. 
         FIG. 3  depicts percent change over time for a variety of facial attributes. 
         FIG. 4  depicts percent change over time for corneometer measurements of skin hydration. 
         FIG. 5  depicts percent change over time for cutometer measurements of skin extensibility. 
         FIG. 6  depicts percent change over time for ultrasound measurements of skin density. 
         FIG. 7  shows a schematic diagram for a system, including gene expression level testing devices and data-processing components for carrying out the method disclosed, and data sets developed and used as the method proceeds. 
         FIG. 8  shows the relationships of various data sets and subsets developed leading to a confirmed skin attribute subset defining a functional youth gene assembly. 
     
    
    
     DETAILED DESCRIPTION 
     Definitions 
     The term “functional youth gene assembly” refers to groups of genes encompassing one or more biochemical pathways or mechanisms of aging, addressable for functional restoration or stabilization of a more youthful state in the skin. 
     The term “skin attributes” refers to characteristics or qualities of human skin. 
     The term “biochemical pathway associated with skin” refers to a sequence of reactions and interactions among genes/proteins leading to a specific biochemical end product relevant to at least one skin biological processes. 
     The term “biochemical pathway associated with physical appearance of skin aging” refers to a biochemical pathway that leads to biochemical end products that cause a less youthful state in the skin. 
     The term “skin anti-aging agent” refers to a substance that causes a biological or chemical change in the skin to reflect a more youthful state in the skin. 
     Reference is now made in detail to certain embodiments of systems and methods. The disclosed embodiments are not intended to be limiting of the claims. To the contrary, the claims are intended to cover all alternatives, modifications, and equivalents. 
     The present disclosure provides a system and method in which the genes expressed in human derived skin cells in a human equivalent skin tissue model are tested for linkage to the physical appearance of human facial skin aging. Human derived skin cells include, for example, fibroblasts, keratinocytes, adipocytes and melanocytes. 
     Gene expression profiling using high-throughput methodologies such as DNA microarrays has proven to be a powerful approach in exploring the complex processes of aging, which involve many genetic pathways. This technique allows researchers to scan essentially the entire genome for age-related changes in gene expression, or changes in gene expression as a result of anti-aging strategies. Such analyses have demonstrated an association between aging and widespread gene expression. (Solene M, Fortunel N O, Pageon H, Asselineau D,  Aging alters functionally human dermal papillary fibroblasts but not reticular fibroblasts: A new view of skin morphogenesis and aging . PLoS ONE 3(12):e4066, 2008). 
     If one first examines genes associated with specific mechanisms of aging, then by grouping genes from several mechanisms (associated with attributes of aging or preserving youthfulness) one can compile a functional youth gene profile expression or a functional youth gene assembly that is associated with a specific tissue, such as the skin, and specific attributes of it. 
     Agents 
     An agent generally refers to a substance that causes a change in tissue observed. An agent is chosen based on the ability (or expected ability) of the agent to affect signs of aging, presumably by reason of an effect on expression levels of genes or gene products, including epigenetic effects. 
     Salicin is an agent that has shown effects on multiple signs of skin aging. See Applicant&#39;s co-pending patent application Ser. No. 12/058,201, publication number US 2009/0246152 A1, hereby incorporated by reference in its entirety. 
     In some embodiments, the skin anti-aging agent chosen for the experimental testing is salicin. Salicin (C 13 H 18 O 7 ) or 2-(Hydroxymethyl)phenyl β-D-glucospyranoside) is an alcoholic beta-glycoside that contains D-glucose. Salicin is obtained from several species of the white willow bark tree. Salicin is commercially available as a white, crystalline, water soluble powder from, for example, Sigma-Aldrich (St. Louis, Mo.). 
     Other agents may be chosen based on the ability of the substance to bring about a biological or chemical effect in tissue to reflect a more youthful state of the tissue. Choice of an agent is dependent upon the objective one is trying to obtain. An agent could be chosen for its apparent wide-spectrum anti-aging benefits, including effect on skin hydration, skin structure, skin pigmentation and skin cell turnover, or an agent could be chosen specifically for a single objective, e.g., hydration of the skin, associated with a more youthful state of epidermal tissue. For example, ingredients such as retinoids, niacinamide, N-acetyl glucosamine have a wide spectrum of anti-aging benefits. 
     DNA Microarray Technology 
     Data Processing Overview 
     In various aspects, the present disclosure relates to the analysis of skin tissue samples by microarray-based technology and transforming the microarray output data into useful subsets of data identifying particular genes of interest. 
     In some embodiments, the methods of the present disclosure comprise analyzing at least one test sample of a skin anti-aging agent on human or human-derived skin tissue, by using microarray-based technology to obtain information relating to changes in expression levels, if any. 
     A reference sample is a sample that lacks the presence of a skin anti-aging agent. Test and reference samples may be obtained from a biological source comprising human or human-derived skin cells or human or human-equivalent tissue, by any suitable method of nucleic acid isolation and/or extraction. In various aspects, the test sample and the reference sample are extracted RNA. 
     Array hybridization experiments allow the analysis of thousands of genes in one experiment. Microarrays are solid supports made of either nylon or silicon which house thousands of transcripts at fixed locations. The DNA is printed, spotted or synthesized on the support. This method is based on hybridization probing which uses fluorescently labeled nucleic acids as probes to identify complementary sequences. Single stranded DNA is made up of 4 different nucleotides, adenine (A), thymine (T), guanine (G), and cytosine (C). Adenine pairs with thymine and guanine pairs with cytosine. Hybridization occurs when a group of nucleotides finds their complementary partners. Microarray experiments measure the level of hybridization of each DNA on the support via fluorescently labeled tags. 
     There are three different types of probes that are commonly used in hybridization experiments: genomic DNA probes, cDNA probes and oligonucleotide probes. This provides the different terms namely “DNA array”, “cDNA array” or “oligonucleotide array” depending on what type of probe is used. (Kumar, A., Goel, G., Fehrenbach, E., Puniya, K. A., Singh, K. Microarrays: The Technology, Analysis and Application,  Engineering in Life Sciences  5(3), 215-222 (2005); Jiang, N. et al. Methods for evaluating gene expression from Affymetrix microarray datasets,  BMC Bioinformatics  9, 284 (2008); Auer, H., Newsom, D. L., Kornacker, K. Expression Profiling Using Affymetrix GeneChip Microarrays,  Methods Mol Biol.  509, 35-46 (2009)). 
     In conducting a DNA microarray experiment, total RNA is extracted from the samples to be tested. The purified RNA is then analyzed for quality and quantity (&gt;1 micrograms). Reverse transcriptase is then used to transcribe the mRNA into cDNA. The nucleotides used to synthesize the cDNA are labeled with either a green or red dye, one color for reference conditions or the other color for experimental conditions. The test samples and the reference samples may be differentially labeled with any detectable substance or moieties. The detectable substances or moieties may be selected such that they generate signals that can be readily measured and such that the intensity of the signals is proportional to the amount of labeled nucleic acids present in the sample. The detectable substances or moieties may also be selected such that they generate localized signals, thereby allowing resolution of the signals from each spot on an array. 
     Methods for labeling nucleic acids are well-known in the art. For exemplary reviews of labeling protocols, label detection techniques and recent developments in the field, (see e.g., Kricka, Ann, Clin. Biochem. (2002), 39: 114-129; van Gijlswijk et al., Expert Rev. Mol. Diagn. (2001), 1:81-91; and Joos et al., J. Biotechnol. (1994), 35: 135-153). Standard nucleic acid labeling methods include: incorporation of radioactive agents, direct attachment of fluorescent dyes or of enzymes, chemical modification of nucleic acids to make them detectable immunochemically or by other affinity reactions, and enzyme-mediated labeling methods including, without limitation, random priming, nick translation, PCR and tailing with terminal transferase. Other suitable labeling methods include psoralen-biotin, photoreactive azido derivatives, and DNA alkylating agents. In various embodiments, test sample and reference sample nucleic acids are labeled by Universal Linkage System, which is based on the reaction of monoreactive cisplatin derivatives with the N7 position of guanine moieties in DNA (see, e.g., Heetebrij et al., Cytogenet. Cell. Genet. (1999), 87: 47-52). 
     Any of a wide variety of detectable substances or moieties can be used to label test and/or reference samples. Suitable detectable substances or moieties include, but are not limited to: various ligands; radioneuclides such as, for example,  32 P,  35 S,  3 H,  14 C,  125 I,  131 I, and others; fluorescent dyes; chemiluminescent agents such as, for example, acridinium esters, stabilized dioxetanes, and others; microparticles such as, for example, quantum dots, nanocrystals, phosphors and others; enzymes such as, for example, those used in an ELISA, horseradish peroxidase, beta-galactosidase, luciferase, alkaline phosphatase and others; colorimetric labels such as, for example, dyes, colloidal gold and others; magnetic labels such as, for example, Dynabeads™ particles; and biotin, dioxigenin or other haptens and proteins for which antisera or monoclonal antibodies are available. 
     The microarray or chip used for testing is then incubated overnight with both reference and experimental cDNAs. Certain cDNA will hybridize with the complementary strands from its gene that is covalently bound to a grid spot on the chip. The chips are then washed to remove any unbound cDNAs. Two computerized images are then produced by scanning first to detect the grid spots containing cDNAs labeled with green dye, and second to detect the spots containing the red-labeled cDNAs. The computer also produces a combination of the two images showing a yellow spot for grids spots containing both red and green labeled cDNAs. These yellow spots represent transcripts that are expressed under both sets of conditions. 
     In addition to producing images, microarray experiments yields quantitative data for each spot on the chip, resulting in large datasets where bioinformatics tools are needed for complete analysis. Parametric t-test with a Benjamini and Hochberg false discovery rate correction is the most common statistical parameter used for microarrays to identify genes with a statistically significant p value equal to or less than 0.05 and with a fold change of 2.0 and greater (or other suitable expression level criterion, expressed as a fold change threshold or otherwise). Genes are then either grouped by biological function or relation to a particular disease, depending on the objectives of the study. 
     These array-based methods of genetic analyses for skin cell samples allow the research analyst to develop data for essentially the entire human genome as an initial step, but economics and the need to limit focus make it desirable to analyze this data with a goal of limiting the number of genes addressed in later analysis steps. Techniques to permit focusing of resources on particular conditions, mechanisms and interventions can save time and cost. 
     The array-based data is of sufficient volume that it is desirable (and likely necessary) to carry out the analysis that transforms a genome-wide set of data from microarray equipment into smaller, focused sets of data using a computer-based system.  FIG. 7  shows a schematic diagram for a system  700 , including data-processing components, for carrying out the method disclosed, including data sets developed and processed as the method proceeds. System  700  includes a data processing system  710  that may be implemented with a desktop computer, a cluster of computers, a group of computer resources in a cloud, a supercomputer or any other configuration of at least one CPU, memory and an operating system  712  that permits data from a full genome microarray  780  to be received in a database  730 . The system  700  further includes various process application modules  720 , including statistics modules  722  and other data processing modules and parameters  724  for performing steps outlined in the flowchart of  FIGS. 1A-1K  that carry out the data processing described in greater detail below. The database  730  receives from the microarray  780  raw or semiprocessed data that are produced in one or more runs of the microarray. This data may include data comprising a full genome data set  750   a  derived from a sample of agent-exposed tissue  782  and from a full genome control data set  750   b  derived from a sample of tissue not agent-exposed  784 . These data will be subject to computations that produce a further data set  750   c , with computed ratios by gene of levels of gene expression in exposed and unexposed tissue ( 782 / 784 ) as detected by microarray  780 . The computations further include applying to this data set of ratios  750   c  a criterion for whether the level of gene expression associated with the agent, is significant, in either an up-regulated or a down-regulated direction. The criterion may be a selected and stored parameter in the applications modules  720 , specifically in the data processing modules and parameters  724 . Application of a stored “fold” criterion to the ratio data set  750   c  for the full genome yields a fold criterion data set  752 , i.e., a data set listing genes found by testing to have a level of expression in the agent-exposed tissue that meet the fold criterion. 
     Also in the database  730  are data sets developed from literature  786  on the biological pathways that have been reported as associated with various genes. One data set  754  identifies genes reported as having biological pathways that are significant for skin. (The data set  754  may be derived from literature by automated keyword and/or metadata analysis of the text of scientific journals, patents or other sources reporting on activity of particular genes, including non-published studies, or may be built by the input of one or more scientific experts. For this purpose, it may be helpful to build a database of sources annotated with metadata  787  that permit ready identification of each gene associated with skin (or other organs) and, for genes associated with skin, as addressing biochemical pathways associated with particular skin attributes.) This data set may be used in an intersection analysis to identify the genes in a larger test result data set, for example the full genome microarray data sets  750   a ,  750   b  or the fold criterion result data set  752 , that are related to skin and also meet the specified fold criterion that led to the fold criterion result data set  752 , forming a new skin pathway intersection data set  755 . Thus, the literature data set  754  may be used as a filter for the test data to provide a focus on genes for which data from the literature data set supports a pathway of interest in skin. 
     The data sets derived from literature can also have a narrower focus within the broader area of skin. For example, a skin attribute data set  756  may be derived that identifies genes reported as having biological pathways that are significant for a particular attribute of skin, such as skin structure or skin pigmentation. Such a data set may be used in an intersection analysis to identify the genes in a larger test result data set, for example the skin pathway intersection data set  755 , to identify genes that are related to a specific skin structure and also meet the specified fold criterion that led to the fold criterion data set  752 , forming a new skin attribute intersection data set  758 . The skin attribute intersection data set  758  is then focused on genes related to one specific skin structure; an attribute data set  756  for another skin attribute, e.g., skin pigmentation, can lead to a different skin attribute intersection data set  758 . At this level of focus, assuming the goal of focus is to identify genes associated with more youthful manifestations of a skin attribute, the skin attribute data sets also include up or down regulation coding. That is, if a gene is associated with a particular skin attribute, it may be reported as involved in either the up or down regulation of a pathway that either leads to more or less youthful appearance. To the extent a goal is to identify agents to influence biological pathways that enhance youthfulness, it is significant to identify both the genes that can be up-regulated to cause a more youthful state, as well as the genes that can be down-regulated to reduce action of a pathway that leads to less youthful state. Thus, the skin attribute data sets  756  are coded to identify for each gene, the up or down regulation of a pathway that either leads to more or less youthful appearance as to the particular skin attribute involved. 
     The results embodied in a skin attribute intersection data set  758  may be considered preliminary and will be considered more reliable if they can in some way be confirmed, or refined. The present system in one embodiment develops and analyzes further data to provide possible confirmation and refining. As seen in  FIG. 7 , a second instrument for determining levels of gene expression, such as an instrument  790  that relies on PCR techniques for determining expression levels may be employed. The candidate genes whose expression level is the focus for testing in this instrument are selected based on one or more of the skin attribute data sets  758 . In one embodiment, the candidate genes identified in one of these sets  758  may be supplemented for second instrument testing with other candidate genes of interest, based on secondary research or simply because they are useful to provide reference values. In one embodiment, the other candidate genes of interest may be selected by searching in literature and in fold criterion result data  752  for genes associated with aging (although not specifically with skin aging) and showing up regulation of an anti-aging biochemical pathway. Thus, a PCR Candidate data set  760  is assembled to define the analytical focus of gene expression level testing in the PCR Testing instrument  790 . 
     The test result data from the PCR Testing instrument  790  show levels of gene expression for the selected candidate genes when the same agent used to develop data in the upper portion of  FIG. 7  is exposed to a new tissue sample. In one embodiment, this is the same type of skin tissue sample as used to develop data in microarray  780  in the upper portion of  FIG. 7 . The level of gene expression data, e.g., PCR ΔC T  data  762 , are developed for each selected candidate gene. These data are statistically cleaned and processed, then correlated with a particular skin attribute intersection data set  758  having the same genes or with data for corresponding genes found in data sets  752  or  755 . In some instances, for a particular candidate gene, a high level of expression in the same direction as was associated with more youthful appearance in the intersection data set  758  will confirm that the gene and its associated biological pathway(s) appears to be capable of agent stimulation for expression that leads to more youthful appearance as to a particular skin attribute. A set of such genes then may become part of a final functional youth gene assembly  770  for the skin attribute. A different set of candidate data  760  based on a different skin attribute intersection data set  758 , and the set of PCR ΔC T  test data  762  developed for those candidates may become part of a final functional youth gene assembly  772  for a different skin attribute. Each such assembly would appear to provide a more useful and economic focus for further study than any whole genome study. The processes leading the various data sets identified in  FIG. 7  are discussed in greater detail below. 
     The discussion below proceeds at two levels. At one level, with reference to  FIGS. 1A-1K , a highly simplified example assuming a genome with only genes a-h and with entirely hypothetical data is used to show the process steps. At a second level, with reference to Tables 1-6, the same process is described, but Tables 1-6 show actual test data from lab testing using actual skin tissue samples and equipment that finds expression levels for actual genes that are included in the human genome and the literature data sets ( 754 ,  756 ) are derived from actual gene literature. 
     Global Gene Expression Levels 
     In the present method and system, expression profiling for thousands of genes, substantially all of the genes of the human genome, is performed to determine a first set of expression levels of a plurality of genes in a first sample of agent-exposed human or human derived skin. 
     Genome refers to all nucleic acid sequences, coding and non-coding, present in each cell type of a subject. The term also includes all naturally occurring or induced variations of these sequences that may be present in a mutant or disease variant of any cell type, including, for example, tumor cells. Genomic DNA and genomic nucleic acids are thus nucleic acids isolated from a nucleus of one or more cells, and include nucleic acids derived from, isolated from, amplified from, or cloned from genomic DNA, as well as synthetic versions of all or any part of a genome. 
     For example, the human genome consists of approximately 3.0×10 9  base pairs of DNA organized into 46 distinct chromosomes. The genome of a normal human diploid somatic cell consists of 22 pairs of autosomes (chromosomes 1 to 22) and either chromosomes X and Y (male) or a pair of chromosome Xs (female) for a total of 46 chromosomes. 
     In some embodiments, Affymetrix® DNA microarray technology is used for measuring global gene expression in human in vitro skin cultures. Microarrays are ideal for simultaneously measuring the effects of a test compound on the activity of thousands of genes in the human genome. (Microchip Methods in Diagnostics, vol. 509, chapter 3, Expression Profiling Using Affymetrix GeneChip Microarrays, Auer et al. (2009)). 
     For one embodiment, EpidermFT™ Skin Model (EFT-400) full thickness skin cultures (MatTek Corp, Ashland, Mass.) is used as a skin model. These cultures contain normal, human-derived epidermal keratinocytes from neonatal foreskin tissue and normal human-derived dermal fibroblasts, from mammary tissue. These cells are cultured to form a multilayered, highly differentiated model of the human dermis and epidermis. The model parallels human skin and is useful for in vitro testing, where a microarray is used to develop and collect data. Skin models typically contain human derived skin cells cultured to form a model of skin tissue. Generally, these skin models are referred to as “human equivalent skin tissue” or “human derived skin tissue”. Skin cells include keratinocytes, fibroblasts, adipocytes and melanocytes. 
       FIGS. 1A-1K  show steps in a flowchart  100  with steps for choosing from the simplified hypothetical genes a-h, genes for a functional youth gene assembly. Reference numerals associated with method steps and tabular data on flowchart  100  appear in the description of the method below. 
     The steps begin with selecting an agent that is a candidate to help skin appearance  102  (or explore effects of skin aging). In some embodiments, the agent tested is salicin at a concentration of 0.5% salicin, available from Symrise Corporation (Teterborro, N.J.). The salicin is dissolved in water. An agent that has some known effects on skin aging may be useful for revealing gene-based effects, but other agents may be selected. 
     The first samples of the human equivalent skin tissue are exposed to the skin anti-aging agent  104 . Untreated cultures, or human skin tissues not exposed to the agent, serve as controls or reference samples. (See  FIG. 7  at  782 ,  784 ) 
     RNA is extracted from each of the human skin cells, or cultures, using an RNeasy® Fibrous kit (Qiagen, Valencia, Calif.) following the manufacturer&#39;s protocol. (RNeasy® Fibrous Tissue Handbook, November 2006). cDNA is synthesized from 100 ng of total RNA, and then converted to biotin-labeled amplified RNA (aRNA) using an Affymetrix GeneChip® 3′ IVT Express kit, according to the manufacturer&#39;s instructions. (Affymetrix User Manual GeneChip® 3′ IVT Express Kit (2008)). 
     In some embodiments, the samples are hybridized to Affymetrix GeneChip® HG U133 Plus 2.0 microarrays, washed, stained and scanned according to Affymetrix protocols. The microarray laser scanner measures fluorescence intensities of all of the transcripts on the gene chip; the fluorescence of each transcript is compared among each of the samples. (See  FIG. 7  at  780 ). 
     Results from these experiments reveal that the skin anti-aging agent selected for exploration may have influenced the activity of any of more than 15,000 genes in the human genome. 
     The activity is measured by determining expression levels for genes in the first exposed tissue sample (test sample)  106 . This involves reading the array that has a human equivalent tissue model exposed to the agent. This results in a set of data that is stored in database  730  of a data processing system  710  for implementing the method described herein, (See  FIG. 7  at  750   a ). 
     To give a basis for comparison, the method uses a reference tissue that has not been exposed to the agent. The same skin model is used to provide data on expression levels when the agent is not present. The reference level is measured by determining expression levels for genes in the first unexposed sample (reference sample)  108 . Again, this results in a set of data that is stored in database  730  of a data processing system  710  for implementing the method described herein. (See  FIG. 7  at  750   b ). 
     The agent-exposed and reference data are analyzed to determine the affects of agent exposure. The expression level data for each gene of the test sample are compared with the corresponding data of the reference sample to obtain a ratio of the data  110 . (See  FIG. 7  at  750   c ). At least part of the gathering, storing and comparing of the expression level data is performed by a computer, such as the data processing system  710 , with CPU  712  (see  FIG. 7 ) for performing data access and storage and various computations specified by software modules corresponding to the functions occurring at various described steps of this method. 
     A bioinformatics statistical analysis is conducted on data  112  to identify and characterize candidate genes. A Parametric t-test with a Benjamini and Hochberg false discovery rate correction is the most common statistical parameter used for microarrays to identify genes with a statistically significant p value equal to or less than 0.05 and with a selected biological relevance level, e.g., a fold change of 2.0 and greater. To help organize the results, genes are either grouped by biological function or relation to a particular disease, depending on the objectives of the study. 
     Selecting First Subset of Genes 
     Flowchart  100  in  FIG. 1A  has an illustration of a table of the extremely simplified hypothetical example set of genes (for simplicity identified as “a-h”) with rows showing expression levels in the exposed sample  202 , expression levels in unexposed sample  204 , and the ratio  206  of row  204  compared to row  202  (row  202 ÷ row  204 =row  206 ). (The data in rows  202  and  204  are entirely hypothetical, for purposes of an example, and row  206  shows a computation from the hypothetical data.) 
       FIG. 1B  shows an expanded table of the example set of genes. Row  208  shows the ratios of row  206  as fold changes, reflecting that genes may be up-regulated or down-regulated. 
     The raw dataset from the first subset of genes, row  208 , is then filtered, using bioinformatics methods, to identify and characterize genes. In particular, the data is filtered to focus on genes with biologically relevant fold change values. In data from a typical microarray device, e.g., data from the Affymetrix testing, the up or down regulation of the gene is also identifiable. The row  210  shows the regulation direction of the hypothetical gene. 
     In some embodiments at least part of the analysis of data is performed by a computer. Statistical data analysis may be carried out using GeneSpring GX software (version 10). A parametric t-test with a Benjamini and Hochberg false discovery rate correction is performed to identify genes with a statistically significant p value equal to or less than 0.05. (Statistical analysis may be performed by one or more of the process application modules  720 . (See  FIG. 7 ). In one set of data collected, the 0.05% salicin treated cultures (N=7) are compared with untreated control cultures (N=4) after 24 hours of stimulation. 
     Returning to the simplified example, at step  114 , the system selects a first subset of genes (b, c, e, f, g and h) with biologically relevant fold changes in the level of expression, for example, those calculated to be at least a two fold change. (See row  208 ). As noted with reference to rows  202 ,  204 ,  206 , the ratio is measured from the first exposed sample (test sample), as compared to the first unexposed sample (reference sample). The method also involves identifying which genes are regulated in a particular direction (up or down regulated). (See row  210 ). In one embodiment, a ratio of data in row  202  to data in row  204 , shows up-regulation if the ratio is greater than 1 and down-regulation is the ratio is less that 1. 
     As shown in row  206 , example genes b, c, e, f, g and h have ratios of 3, 2.5, 4, 0.2, 3.33 and 12, respectively. Thus, with a fold change threshold selected at 2, the table in  FIG. 1B  shows the example genes b, c, e, f, g and h, meet the fold change criterion. This is the first subset as described for the hypothetical example. 
     In the test data from skin model experiments, fold changes of at least about 2.0, about 2.0, of at least about 3.0, between about 2.0 and about 4.0, between about 2.0 and about 7.0, and even between 2.0 and about 200.0 may be selected as biologically relevant. Fold change significance may vary based on the instrument used for testing, tissue sample and other factors. For Affymetrix DNA microarray data, using the specific statistically scientific parameter, a fold change of 2 or more is biologically significant. (The fold change criterion is a selectable parameter  724  in process application modules  720 .) 
     As shown on row  206  of the table on  FIG. 1B , example genes a and d have ratios of 1.625 (up), and 0.75 (down), respectively, or fold changes of 1.625 and 1.33, respectively, both below a fold change selection criterion of 2 for up-regulation or down-regulation. By comparison, for gene e, the expression level was higher in the exposed test sample than in the reference, so in comparison to the reference, this gene was up-regulated. The column “f” value would be a “down” regulation gene situation, with a fold change of 5 (a ratio of 2/10=0.2). Thus, gene fin the example also meets the fold change criterion. Genes not meeting the fold change criterion and not chosen for the first subset of genes (a and d, in the example) may be considered for additional research based on secondary research factors  116 . (Secondary research factors are discussed below Table 6.) 
     Correspondingly, as will be seen below and in Table 1, the actual skin model data test results from the microarray instrument  780  were subjected to the same fold change criterion as in the simplified example; thus genes with fold changes reported below 2.0 were not included in any of the tables for skin model actual experimental results. 
     Table 1 below shows experimental data from a microarray for 0.05% salicin treated cultures (N=7) compared with untreated control cultures (N=4) corresponding to the simplified hypothetical data in the table of  FIG. 1B . (See also,  FIG. 7  at  752 ). This is a list of more than 2,300 genes tested by the Affymetrix microarray test methods with filtering of data as described in the example to focus on genes with biologically relevant fold change values. Table 1 thus shows the first subset for the microarray data. 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                   
                 Fold 
                   
                   
                   
               
               
                 Probe Set ID 
                 change 
                 Direction 
                 Gene Symbol 
                 Gene Title 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 1556410_a_at 
                 24.649403 
                 up 
                 KRTAP19-1 
                 keratin associated protein 19-1 
               
               
                 210229_s_at 
                 16.55027 
                 up 
                 CSF2 
                 colony stimulating factor 2 
               
               
                   
                   
                   
                   
                 (granulocyte-macrophage) 
               
               
                 205114_s_at 
                 15.552067 
                 up 
                 CCL3 /// 
                 chemokine (C-C motif) ligand 3 /// 
               
               
                   
                   
                   
                 CCL3L1 /// 
                 chemokine (C-C motif) ligand 3-like 1 
               
               
                   
                   
                   
                 CCL3L3 /// 
                 /// chemokine (C-C motif) ligand 3-like 
               
               
                   
                   
                   
                 LOC728830 
                 3 /// similar to C-C motif chemokine 3- 
               
               
                   
                   
                   
                   
                 like 1 precursor (Small-inducible 
               
               
                   
                   
                   
                   
                 cytokine A3-like 1) (Tonsillar 
               
               
                   
                   
                   
                   
                 lymphocyte LD78 beta protein) 
               
               
                   
                   
                   
                   
                 (LD78-beta(1-70)) (G0/G1 switch 
               
               
                   
                   
                   
                   
                 regulatory protein 19-2) (G0S19-2 
               
               
                   
                   
                   
                   
                 protein) (PAT 464.2) 
               
               
                 213418_at 
                 14.241181 
                 up 
                 HSPA6 
                 heat shock 70 kDa protein 6 (HSP70B′) 
               
               
                 205943_at 
                 12.260297 
                 up 
                 TDO2 
                 tryptophan 2,3-dioxygenase 
               
               
                 214038_at 
                 11.567539 
                 up 
                 CCL8 
                 chemokine (C-C motif) ligand 8 
               
               
                 207442_at 
                 11.09133 
                 up 
                 CSF3 
                 colony stimulating factor 3 
               
               
                   
                   
                   
                   
                 (granulocyte) 
               
               
                 241031_at 
                 10.975465 
                 up 
                 FAM148A 
                 family with sequence similarity 148, 
               
               
                   
                   
                   
                   
                 member A 
               
               
                 225207_at 
                 10.136719 
                 up 
                 PDK4 
                 pyruvate dehydrogenase kinase, 
               
               
                   
                   
                   
                   
                 isozyme 4 
               
               
                 205931_s_at 
                 9.909108 
                 up 
                 CREB5 
                 cAMP responsive element binding 
               
               
                   
                   
                   
                   
                 protein 5 
               
               
                 229228_at 
                 9.767824 
                 up 
                 CREB5 
                 cAMP responsive element binding 
               
               
                   
                   
                   
                   
                 protein 5 
               
               
                 206924_at 
                 9.694227 
                 up 
                 IL11 
                 interleukin 11 
               
               
                 207526_s_at 
                 9.089992 
                 up 
                 IL1RL1 
                 interleukin 1 receptor-like 1 
               
               
                 206569_at 
                 8.736957 
                 up 
                 IL24 
                 interleukin 24 
               
               
                 207850_at 
                 8.702696 
                 up 
                 CXCL3 
                 chemokine (C—X—C motif) ligand 3 
               
               
                 206926_s_at 
                 7.970876 
                 up 
                 IL11 
                 interleukin 11 
               
               
                 206176_at 
                 7.765054 
                 up 
                 BMP6 
                 bone morphogenetic protein 6 
               
               
                 216248_s_at 
                 7.5919886 
                 up 
                 NR4A2 
                 nuclear receptor subfamily 4, group A, 
               
               
                   
                   
                   
                   
                 member 2 
               
               
                 204622_x_at 
                 7.5477886 
                 up 
                 NR4A2 
                 nuclear receptor subfamily 4, group A, 
               
               
                   
                   
                   
                   
                 member 2 
               
               
                 209774_x_at 
                 7.5460076 
                 up 
                 CXCL2 
                 chemokine (C—X—C motif) ligand 2 
               
               
                 233011_at 
                 7.322324 
                 up 
                 ANXA1 
                 Annexin A1, mRNA (cDNA clone 
               
               
                   
                   
                   
                   
                 MGC: 32774 IMAGE: 4662939) 
               
               
                 217388_s_at 
                 7.295115 
                 up 
                 KYNU 
                 kynureninase (L-kynurenine hydrolase) 
               
               
                 216979_at 
                 7.203941 
                 up 
                 NR4A3 
                 nuclear receptor subfamily 4, group A, 
               
               
                   
                   
                   
                   
                 member 3 
               
               
                 204621_s_at 
                 7.06227 
                 up 
                 NR4A2 
                 nuclear receptor subfamily 4, group A, 
               
               
                   
                   
                   
                   
                 member 2 
               
               
                 1554685_a_at 
                 7.039142 
                 up 
                 KIAA1199 
                 KIAA1199 
               
               
                 228501_at 
                 6.957408 
                 up 
                 GALNTL2 
                 UDP-N-acetyl-alpha-D- 
               
               
                   
                   
                   
                   
                 galactosamine:polypeptide N- 
               
               
                   
                   
                   
                   
                 acetylgalactosaminyltransferase-like 2 
               
               
                 235004_at 
                 6.917818 
                 up 
                 RBM24 
                 RNA binding motif protein 24 
               
               
                 202643_s_at 
                 6.915339 
                 up 
                 TNFAIP3 
                 tumor necrosis factor, alpha-induced 
               
               
                   
                   
                   
                   
                 protein 3 
               
               
                 235086_at 
                 6.8579264 
                 up 
                 THBS1 
                 (clone lambda-TS-33) thrombospondin 
               
               
                   
                   
                   
                   
                 (THBS) mRNA, 5′ end 
               
               
                 206382_s_at 
                 6.826926 
                 up 
                 BDNF 
                 brain-derived neurotrophic factor 
               
               
                 1554997_a_at 
                 6.812711 
                 up 
                 PTGS2 
                 prostaglandin-endoperoxide synthase 2 
               
               
                   
                   
                   
                   
                 (prostaglandin G/H synthase and 
               
               
                   
                   
                   
                   
                 cyclooxygenase) 
               
               
                 237411_at 
                 6.7217474 
                 up 
                 ADAMTS6 
                 ADAM metallopeptidase with 
               
               
                   
                   
                   
                   
                 thrombospondin type 1 motif, 6 
               
               
                 212942_s_at 
                 6.522843 
                 up 
                 KIAA1199 
                 KIAA1199 
               
               
                 230748_at 
                 6.4130154 
                 up 
                 SLC16A6 
                 solute carrier family 16, member 6 
               
               
                   
                   
                   
                   
                 (monocarboxylic acid transporter 7) 
               
               
                 239367_at 
                 6.3149343 
                 up 
                 BDNF 
                 brain-derived neurotrophic factor 
               
               
                 204932_at 
                 6.287326 
                 up 
                 TNFRSF11B 
                 tumor necrosis factor receptor 
               
               
                   
                   
                   
                   
                 superfamily, member 11b 
               
               
                 204933_s_at 
                 6.249607 
                 up 
                 TNFRSF11B 
                 tumor necrosis factor receptor 
               
               
                   
                   
                   
                   
                 superfamily, member 11b 
               
               
                 236361_at 
                 6.174206 
                 up 
                 GALNTL2 
                 UDP-N-acetyl-alpha-D- 
               
               
                   
                   
                   
                   
                 galactosamine:polypeptide N- 
               
               
                   
                   
                   
                   
                 acetylgalactosaminyltransferase-like 2 
               
               
                 208075_s_at 
                 6.120267 
                 up 
                 CCL7 
                 chemokine (C-C motif) ligand 7 
               
               
                 226614_s_at 
                 6.0170407 
                 up 
                 FAM167A 
                 family with sequence similarity 167, 
               
               
                   
                   
                   
                   
                 member A 
               
               
                 206137_at 
                 5.972218 
                 up 
                 RIMS2 
                 regulating synaptic membrane 
               
               
                   
                   
                   
                   
                 exocytosis 2 
               
               
                 210133_at 
                 5.958449 
                 up 
                 CCL11 
                 chemokine (C-C motif) ligand 11 
               
               
                 1557257_at 
                 5.733714 
                 up 
                 BCL10 
                 CDNA FLJ25924 fis, clone CBR05109 
               
               
                 215078_at 
                 5.7122235 
                 up 
                 SOD2 
                 superoxide dismutase 2, mitochondrial 
               
               
                 202644_s_at 
                 5.7050176 
                 up 
                 TNFAIP3 
                 tumor necrosis factor, alpha-induced 
               
               
                   
                   
                   
                   
                 protein 3 
               
               
                 221577_x_at 
                 5.573193 
                 up 
                 GDF15 
                 growth differentiation factor 15 
               
               
                 206407_s_at 
                 5.516013 
                 up 
                 CCL13 
                 chemokine (C-C motif) ligand 13 
               
               
                 216598_s_at 
                 5.407172 
                 up 
                 CCL2 
                 chemokine (C-C motif) ligand 2 
               
               
                 203708_at 
                 5.313648 
                 up 
                 PDE4B 
                 phosphodiesterase 4B, cAMP-specific 
               
               
                   
                   
                   
                   
                 (phosphodiesterase E4 dunce homolog, 
               
               
                   
                   
                   
                   
                   Drosophila ) 
               
               
                 242809_at 
                 5.274104 
                 up 
                 IL1RL1 
                 ST2 protein 
               
               
                 209840_s_at 
                 5.160858 
                 up 
                 LRRN3 
                 leucine rich repeat neuronal 3 
               
               
                 204748_at 
                 5.148792 
                 up 
                 PTGS2 
                 prostaglandin-endoperoxide synthase 2 
               
               
                   
                   
                   
                   
                 (prostaglandin G/H synthase and 
               
               
                   
                   
                   
                   
                 cyclooxygenase) 
               
               
                 203645_s_at 
                 5.145445 
                 up 
                 CD163 
                 CD163 molecule 
               
               
                 209841_s_at 
                 5.0964932 
                 up 
                 LRRN3 
                 leucine rich repeat neuronal 3 
               
               
                 207038_at 
                 5.0897655 
                 up 
                 SLC16A6 
                 solute carrier family 16, member 6 
               
               
                   
                   
                   
                   
                 (monocarboxylic acid transporter 7) 
               
               
                 211302_s_at 
                 5.000998 
                 up 
                 PDE4B 
                 phosphodiesterase 4B, cAMP-specific 
               
               
                   
                   
                   
                   
                 (phosphodiesterase E4 dunce homolog, 
               
               
                   
                   
                   
                   
                   Drosophila ) 
               
               
                 210663_s_at 
                 4.9557395 
                 up 
                 KYNU 
                 kynureninase (L-kynurenine hydrolase) 
               
               
                 215506_s_at 
                 4.9070177 
                 up 
                 DIRAS3 
                 DIRAS family, GTP-binding RAS-like 3 
               
               
                 220817_at 
                 4.90531 
                 up 
                 TRPC4 
                 transient receptor potential cation 
               
               
                   
                   
                   
                   
                 channel, subfamily C, member 4 
               
               
                 215501_s_at 
                 4.860024 
                 up 
                 DUSP10 
                 dual specificity phosphatase 10 
               
               
                 209990_s_at 
                 4.7615633 
                 up 
                 GABBR2 
                 gamma-aminobutyric acid (GABA) B 
               
               
                   
                   
                   
                   
                 receptor, 2 
               
               
                 203680_at 
                 4.729812 
                 up 
                 PRKAR2B 
                 protein kinase, cAMP-dependent, 
               
               
                   
                   
                   
                   
                 regulatory, type II, beta 
               
               
                 207815_at 
                 4.719714 
                 up 
                 PF4V1 
                 platelet factor 4 variant 1 
               
               
                 206167_s_at 
                 4.7120314 
                 up 
                 ARHGAP6 
                 Rho GTPase activating protein 6 
               
               
                 210997_at 
                 4.711954 
                 up 
                 HGF 
                 hepatocyte growth factor (hepapoietin 
               
               
                   
                   
                   
                   
                 A; scatter factor) 
               
               
                 213524_s_at 
                 4.7030506 
                 up 
                 G0S2 
                 G0/G1switch 2 
               
               
                 206950_at 
                 4.684502 
                 up 
                 SCN9A 
                 sodium channel, voltage-gated, type 
               
               
                   
                   
                   
                   
                 IX, alpha 
               
               
                   
                   
                   
                   
                 subunit 
               
               
                 215049_x_at 
                 4.532594 
                 up 
                 CD163 
                 CD163 molecule 
               
               
                 224071_at 
                 4.5009127 
                 up 
                 IL20 
                 interleukin 20 
               
               
                 232017_at 
                 4.4948945 
                 up 
                 TJP2 
                 tight junction protein 2 (zona 
               
               
                   
                   
                   
                   
                 occludens 2) 
               
               
                 239461_at 
                 4.4746847 
                 up 
                 GALNTL2 
                 UDP-N-acetyl-alpha-D- 
               
               
                   
                   
                   
                   
                 galactosamine:polypeptide N- 
               
               
                   
                   
                   
                   
                 acetylgalactosaminyltransferase-like 2 
               
               
                 205681_at 
                 4.474304 
                 up 
                 BCL2A1 
                 BCL2-related protein A1 
               
               
                 201107_s_at 
                 4.4725666 
                 up 
                 THBS1 
                 thrombospondin 1 
               
               
                 203895_at 
                 4.4250426 
                 up 
                 PLCB4 
                 phospholipase C, beta 4 
               
               
                 212353_at 
                 4.4241323 
                 up 
                 SULF1 
                 sulfatase 1 
               
               
                 1569020_at 
                 4.418171 
                 up 
                 NEDD9 
                 neural precursor cell expressed, 
               
               
                   
                   
                   
                   
                 developmentally down-regulated 9 
               
               
                 242329_at 
                 4.370621 
                 up 
                 LOC401317 
                 hypothetical LOC401317 
               
               
                 217999_s_at 
                 4.368414 
                 up 
                 PHLDA1 
                 pleckstrin homology-like domain, 
               
               
                   
                   
                   
                   
                 family A, member 1 
               
               
                 220088_at 
                 4.3576527 
                 up 
                 C5AR1 
                 complement component 5a receptor 1 
               
               
                 213921_at 
                 4.35561 
                 up 
                 SST 
                 somatostatin 
               
               
                 210998_s_at 
                 4.350414 
                 up 
                 HGF 
                 hepatocyte growth factor (hepapoietin 
               
               
                   
                   
                   
                   
                 A; scatter factor) 
               
               
                 205992_s_at 
                 4.32588 
                 up 
                 IL15 
                 interleukin 15 
               
               
                 242767_at 
                 4.3130975 
                 up 
                 LMCD1 
                 CDNA FLJ52480 complete cds, highly 
               
               
                   
                   
                   
                   
                 similar to LIM and cysteine-rich 
               
               
                   
                   
                   
                   
                 domains protein 1 
               
               
                 203817_at 
                 4.3071494 
                 up 
                 GUCY1B3 
                 guanylate cyclase 1, soluble, beta 3 
               
               
                 203304_at 
                 4.288485 
                 up 
                 BAMBI 
                 BMP and activin membrane-bound 
               
               
                   
                   
                   
                   
                 inhibitor homolog ( Xenopus laevis ) 
               
               
                 237132_at 
                 4.2871304 
                 up 
                 TJP2 
                 tight junction protein 2 (zona 
               
               
                   
                   
                   
                   
                 occludens 2) 
               
               
                 207332_s_at 
                 4.2861505 
                 up 
                 TFRC 
                 transferrin receptor (p90, CD71) 
               
               
                 201860_s_at 
                 4.228699 
                 up 
                 PLAT 
                 plasminogen activator, tissue 
               
               
                 1552694_at 
                 4.2249846 
                 up 
                 SLC2A13 
                 solute carrier family 2 (facilitated 
               
               
                   
                   
                   
                   
                 glucose transporter), member 13 
               
               
                 117_at 
                 4.210481 
                 up 
                 HSPA6 
                 heat shock 70 kDa protein 6 (HSP70B′) 
               
               
                 207978_s_at 
                 4.165331 
                 up 
                 NR4A3 
                 nuclear receptor subfamily 4, group A, 
               
               
                   
                   
                   
                   
                 member 3 
               
               
                 200664_s_at 
                 4.1382117 
                 up 
                 DNAJB1 
                 DnaJ (Hsp40) homolog, subfamily B, 
               
               
                   
                   
                   
                   
                 member 1 
               
               
                 229160_at 
                 4.13802 
                 up 
                 MUM1L1 
                 melanoma associated antigen (mutated) 
               
               
                   
                   
                   
                   
                 1-like 1 
               
               
                 220818_s_at 
                 4.1121902 
                 up 
                 TRPC4 
                 transient receptor potential cation 
               
               
                   
                   
                   
                   
                 channel, subfamily C, member 4 
               
               
                 210755_at 
                 4.1063404 
                 up 
                 HGF 
                 hepatocyte growth factor (hepapoietin 
               
               
                   
                   
                   
                   
                 A; scatter factor) 
               
               
                 217371_s_at 
                 4.106031 
                 up 
                 IL15 
                 interleukin 15 
               
               
                 204160_s_at 
                 4.1003046 
                 up 
                 ENPP4 
                 ectonucleotide 
               
               
                   
                   
                   
                   
                 pyrophosphatase/phosphodiesterase 4 
               
               
                   
                   
                   
                   
                 (putative function) 
               
               
                 205476_at 
                 4.091709 
                 up 
                 CCL20 
                 chemokine (C-C motif) ligand 20 
               
               
                 203549_s_at 
                 4.0753236 
                 up 
                 LPL 
                 lipoprotein lipase 
               
               
                 234066_at 
                 4.0528307 
                 up 
                 IL1RL1 
                 ST2 protein 
               
               
                 203896_s_at 
                 4.0160823 
                 up 
                 PLCB4 
                 phospholipase C, beta 4 
               
               
                 1556134_a_at 
                 3.9963338 
                 up 
                 B3GNT5 
                   Homo sapiens , clone 
               
               
                   
                   
                   
                   
                 IMAGE: 5122250, mRNA 
               
               
                 205410_s_at 
                 3.9841306 
                 up 
                 ATP2B4 
                 ATPase, Ca++ transporting, plasma 
               
               
                   
                   
                   
                   
                 membrane 4 
               
               
                 210287_s_at 
                 3.9503276 
                 up 
                 FLT1 
                 fms-related tyrosine kinase 1 (vascular 
               
               
                   
                   
                   
                   
                 endothelial growth factor/vascular 
               
               
                   
                   
                   
                   
                 permeability factor receptor) 
               
               
                 219778_at 
                 3.9186013 
                 up 
                 ZFPM2 
                 zinc finger protein, multitype 2 
               
               
                 204273_at 
                 3.9157705 
                 up 
                 EDNRB 
                 endothelin receptor type B 
               
               
                 208691_at 
                 3.9147308 
                 up 
                 TFRC 
                 transferrin receptor (p90, CD71) 
               
               
                 1556629_a_at 
                 3.913148 
                 up 
                 SNAP25 
                 HUMSNAP25B(F) 
               
               
                 209960_at 
                 3.912294 
                 up 
                 HGF 
                 hepatocyte growth factor (hepapoietin 
               
               
                   
                   
                   
                   
                 A; scatter factor) 
               
               
                 228962_at 
                 3.9099233 
                 up 
                 PDE4D 
                 phosphodiesterase 4D, cAMP-specific 
               
               
                   
                   
                   
                   
                 (phosphodiesterase E3 dunce homolog, 
               
               
                   
                   
                   
                   
                   Drosophila ) 
               
               
                 1553133_at 
                 3.861553 
                 up 
                 C9orf72 
                 chromosome 9 open reading frame 72 
               
               
                 204421_s_at 
                 3.8445234 
                 up 
                 FGF2 
                 fibroblast growth factor 2 (basic) 
               
               
                 229435_at 
                 3.841224 
                 up 
                 GLIS3 
                 GLIS family zinc finger 3 
               
               
                 214582_at 
                 3.8272183 
                 up 
                 PDE3B 
                 phosphodiesterase 3B, cGMP-inhibited 
               
               
                 229199_at 
                 3.8180137 
                 up 
                 SCN9A 
                 sodium channel, voltage-gated, type 
               
               
                   
                   
                   
                   
                 IX, alpha subunit 
               
               
                 203548_s_at 
                 3.8146515 
                 up 
                 LPL 
                 lipoprotein lipase 
               
               
                 224219_s_at 
                 3.8127234 
                 up 
                 TRPC4 
                 transient receptor potential cation 
               
               
                   
                   
                   
                   
                 channel, subfamily C, member 4 
               
               
                 202422_s_at 
                 3.7855804 
                 up 
                 ACSL4 
                 acyl-CoA synthetase long-chain family 
               
               
                   
                   
                   
                   
                 member 4 
               
               
                 204385_at 
                 3.7706523 
                 up 
                 KYNU 
                 kynureninase (L-kynurenine hydrolase) 
               
               
                 206701_x_at 
                 3.767451 
                 up 
                 EDNRB 
                 endothelin receptor type B 
               
               
                 212099_at 
                 3.7642062 
                 up 
                 RHOB 
                 ras homolog gene family, member B 
               
               
                 227176_at 
                 3.7533486 
                 up 
                 SLC2A13 
                 solute carrier family 2 (facilitated 
               
               
                   
                   
                   
                   
                 glucose transporter), member 13 
               
               
                 201044_x_at 
                 3.7260537 
                 up 
                 DUSP1 
                 dual specificity phosphatase 1 
               
               
                 205266_at 
                 3.7018826 
                 up 
                 LIF 
                 leukemia inhibitory factor (cholinergic 
               
               
                   
                   
                   
                   
                 differentiation factor) 
               
               
                 221563_at 
                 3.6977322 
                 up 
                 DUSP10 
                 dual specificity phosphatase 10 
               
               
                 230258_at 
                 3.689173 
                 up 
                 GLIS3 
                 GLIS family zinc finger 3 
               
               
                 215910_s_at 
                 3.663163 
                 up 
                 FNDC3A 
                 fibronectin type III domain containing 
               
               
                   
                   
                   
                   
                 3A 
               
               
                 215033_at 
                 3.6403422 
                 up 
                 TM4SF1 
                 transmembrane 4 L six family member 1 
               
               
                 215966_x_at 
                 3.6169035 
                 up 
                 GK3P 
                 glycerol kinase 3 pseudogene 
               
               
                 1552695_a_at 
                 3.5807984 
                 up 
                 SLC2A13 
                 solute carrier family 2 (facilitated 
               
               
                   
                   
                   
                   
                 glucose transporter), member 13 
               
               
                 204931_at 
                 3.5795379 
                 up 
                 TCF21 
                 transcription factor 21 
               
               
                 209959_at 
                 3.5782444 
                 up 
                 NR4A3 
                 nuclear receptor subfamily 4, group A, 
               
               
                   
                   
                   
                   
                 member 3 
               
               
                 215034_s_at 
                 3.5756443 
                 up 
                 TM4SF1 
                 transmembrane 4 L six family member 1 
               
               
                 235591_at 
                 3.5697513 
                 up 
                 SSTR1 
                 somatostatin receptor 1 
               
               
                 202843_at 
                 3.5600665 
                 up 
                 DNAJB9 
                 DnaJ (Hsp40) homolog, subfamily B, 
               
               
                   
                   
                   
                   
                 member 9 
               
               
                 231367_s_at 
                 3.558707 
                 up 
                 LOC647131 
                 hypothetical LOC647131 
               
               
                 202508_s_at 
                 3.5226371 
                 up 
                 SNAP25 
                 synaptosomal-associated protein, 
               
               
                   
                   
                   
                   
                 25 kDa 
               
               
                 1569617_at 
                 3.5221984 
                 up 
                 OSBP2 
                 CDNA clone IMAGE: 3632045 
               
               
                 202672_s_at 
                 3.5205257 
                 up 
                 ATF3 
                 activating transcription factor 3 
               
               
                 210837_s_at 
                 3.520149 
                 up 
                 PDE4D 
                 phosphodiesterase 4D, cAMP-specific 
               
               
                   
                   
                   
                   
                 (phosphodiesterase E3 dunce homolog, 
               
               
                   
                   
                   
                   
                   Drosophila ) 
               
               
                 218000_s_at 
                 3.5197904 
                 up 
                 PHLDA1 
                 pleckstrin homology-like domain, 
               
               
                   
                   
                   
                   
                 family A, member 1 
               
               
                 214632_at 
                 3.510114 
                 up 
                 NRP2 
                 neuropilin 2 
               
               
                 215977_x_at 
                 3.509982 
                 up 
                 GK 
                 glycerol kinase 
               
               
                 219935_at 
                 3.4860334 
                 up 
                 ADAMTS5 
                 ADAM metallopeptidase with 
               
               
                   
                   
                   
                   
                 thrombospondin type 1 motif, 5 
               
               
                 209101_at 
                 3.474422 
                 up 
                 CTGF 
                 connective tissue growth factor 
               
               
                 244804_at 
                 3.4737628 
                 up 
                 SQSTM1 
                 Sequestosome 1 (SQSTM1), transcript 
               
               
                   
                   
                   
                   
                 variant 1, mRNA 
               
               
                 212224_at 
                 3.462966 
                 up 
                 ALDH1A1 
                 aldehyde dehydrogenase 1 family, 
               
               
                   
                   
                   
                   
                 member A1 
               
               
                 212354_at 
                 3.4603515 
                 up 
                 SULF1 
                 sulfatase 1 
               
               
                 204422_s_at 
                 3.455492 
                 up 
                 FGF2 
                 fibroblast growth factor 2 (basic) 
               
               
                 229357_at 
                 3.450523 
                 up 
                 ADAMTS5 
                 ADAM metallopeptidase with 
               
               
                   
                   
                   
                   
                 thrombospondin type 1 motif, 5 
               
               
                 209071_s_at 
                 3.4271708 
                 up 
                 RGS5 
                 regulator of G-protein signaling 5 
               
               
                 205088_at 
                 3.4216924 
                 up 
                 MAMLD1 
                 mastermind-like domain containing 1 
               
               
                 217998_at 
                 3.4190629 
                 up 
                 LOC652993 
                 hypothetical LOC652993 /// pleckstrin 
               
               
                   
                   
                   
                 /// PHLDA1 
                 homology-like domain, family A, 
               
               
                   
                   
                   
                   
                 member 1 
               
               
                 227361_at 
                 3.409933 
                 up 
                 HS3ST3B1 
                 heparan sulfate (glucosamine) 3-O- 
               
               
                   
                   
                   
                   
                 sulfotransferase 3B1 
               
               
                 217997_at 
                 3.4090981 
                 up 
                 PHLDA1 
                 pleckstrin homology-like domain, 
               
               
                   
                   
                   
                   
                 family A, member 1 
               
               
                 218177_at 
                 3.39026 
                 up 
                 CHMP1B 
                 chromatin modifying protein 1B 
               
               
                 204271_s_at 
                 3.385063 
                 up 
                 EDNRB 
                 endothelin receptor type B 
               
               
                 204491_at 
                 3.380295 
                 up 
                 PDE4D 
                 phosphodiesterase 4D, cAMP-specific 
               
               
                   
                   
                   
                   
                 (phosphodiesterase E3 dunce homolog, 
               
               
                   
                   
                   
                   
                   Drosophila ) 
               
               
                 229273_at 
                 3.3785377 
                 up 
                 SALL1 
                 sal-like 1 ( Drosophila ) 
               
               
                 206411_s_at 
                 3.3458714 
                 up 
                 ABL2 
                 v-abl Abelson murine leukemia viral 
               
               
                   
                   
                   
                   
                 oncogene homolog 2 (arg, Abelson- 
               
               
                   
                   
                   
                   
                 related gene) 
               
               
                 219195_at 
                 3.344138 
                 up 
                 PPARGC1A 
                 peroxisome proliferator-activated 
               
               
                   
                   
                   
                   
                 receptor gamma, coactivator 1 alpha 
               
               
                 231031_at 
                 3.3397727 
                 up 
                 KGFLP2 
                 keratinocyte growth factor-like protein 2 
               
               
                 206029_at 
                 3.3350718 
                 up 
                 ANKRD1 
                 ankyrin repeat domain 1 (cardiac 
               
               
                   
                   
                   
                   
                 muscle) 
               
               
                 211555_s_at 
                 3.3216224 
                 up 
                 GUCY1B3 
                 guanylate cyclase 1, soluble, beta 3 
               
               
                 217167_x_at 
                 3.3193831 
                 up 
                 GK 
                 glycerol kinase 
               
               
                 210511_s_at 
                 3.3132741 
                 up 
                 INHBA 
                 inhibin, beta A 
               
               
                 210836_x_at 
                 3.3034697 
                 up 
                 PDE4D 
                 phosphodiesterase 4D, cAMP-specific 
               
               
                   
                   
                   
                   
                 (phosphodiesterase E3 dunce homolog, 
               
               
                   
                   
                   
                   
                   Drosophila ) 
               
               
                 207387_s_at 
                 3.2925398 
                 up 
                 GK 
                 glycerol kinase 
               
               
                 209961_s_at 
                 3.291533 
                 up 
                 HGF 
                 hepatocyte growth factor (hepapoietin 
               
               
                   
                   
                   
                   
                 A; scatter factor) 
               
               
                 1554779_s_at 
                 3.281243 
                 up 
                 PHLDB2 
                 pleckstrin homology-like domain, 
               
               
                   
                   
                   
                   
                 family B, member 2 
               
               
                 243357_at 
                 3.2709684 
                 up 
                 NEGR1 
                 neuronal growth regulator 1 
               
               
                 206893_at 
                 3.2649176 
                 up 
                 SALL1 
                 sal-like 1 ( Drosophila ) 
               
               
                 1552632_a_at 
                 3.2559857 
                 up 
                 ARSG 
                 arylsulfatase G 
               
               
                 211844_s_at 
                 3.2455873 
                 up 
                 NRP2 
                 neuropilin 2 
               
               
                 212094_at 
                 3.234917 
                 up 
                 PEG10 
                 paternally expressed 10 
               
               
                 232235_at 
                 3.2294521 
                 up 
                 DSEL 
                 dermatan sulfate epimerase-like 
               
               
                 220416_at 
                 3.2220476 
                 up 
                 ATP8B4 
                 ATPase, class I, type 8B, member 4 
               
               
                 1555257_a_at 
                 3.2004068 
                 up 
                 MYO3B 
                 myosin IIIB 
               
               
                 225566_at 
                 3.1977339 
                 up 
                 NRP2 
                 neuropilin 2 
               
               
                 205207_at 
                 3.1970735 
                 up 
                 IL6 
                 interleukin 6 (interferon, beta 2) 
               
               
                 240556_at 
                 3.1939862 
                 up 
                 DCN 
                 EST from clone 130486, 5′ end 
               
               
                 209387_s_at 
                 3.1869683 
                 up 
                 TM4SF1 
                 transmembrane 4 L six family member 1 
               
               
                 206025_s_at 
                 3.1820982 
                 up 
                 TNFAIP6 
                 tumor necrosis factor, alpha-induced 
               
               
                   
                   
                   
                   
                 protein 6 
               
               
                 233126_s_at 
                 3.1724448 
                 up 
                 OLAH 
                 oleoyl-ACP hydrolase 
               
               
                 209386_at 
                 3.1714027 
                 up 
                 TM4SF1 
                 transmembrane 4 L six family member 1 
               
               
                 205782_at 
                 3.1584346 
                 up 
                 FGF7 
                 fibroblast growth factor 7 (keratinocyte 
               
               
                   
                   
                   
                   
                 growth factor) 
               
               
                 1553271_at 
                 3.1546502 
                 up 
                 DIP2B 
                 DIP2 disco-interacting protein 2 
               
               
                   
                   
                   
                   
                 homolog B ( Drosophila ) 
               
               
                 227487_s_at 
                 3.1483386 
                 up 
                 SERPINE2 
                 Serpin peptidase inhibitor, clade E 
               
               
                   
                   
                   
                   
                 (nexin, plasminogen activator inhibitor 
               
               
                   
                   
                   
                   
                 type 1), member 2 (SERPINE2), 
               
               
                   
                   
                   
                   
                 transcript variant 1, mRNA 
               
               
                 202558_s_at 
                 3.1297736 
                 up 
                 HSPA13 
                 heat shock protein 70 kDa family, 
               
               
                   
                   
                   
                   
                 member 13 
               
               
                 219155_at 
                 3.1254086 
                 up 
                 PITPNC1 
                 phosphatidylinositol transfer protein, 
               
               
                   
                   
                   
                   
                 cytoplasmic 1 
               
               
                 226814_at 
                 3.121966 
                 up 
                 ADAMTS9 
                 ADAM metallopeptidase with 
               
               
                   
                   
                   
                   
                 thrombospondin type 1 motif, 9 
               
               
                 225946_at 
                 3.1174657 
                 up 
                 RASSF8 
                 Ras association (RalGDS/AF-6) 
               
               
                   
                   
                   
                   
                 domain family (N-terminal) member 8 
               
               
                 1554163_at 
                 3.112223 
                 up 
                 TWIST2 
                 twist homolog 2 ( Drosophila ) 
               
               
                 200800_s_at 
                 3.1119442 
                 up 
                 HSPA1A /// 
                 heat shock 70 kDa protein 1A /// heat 
               
               
                   
                   
                   
                 HSPA1B 
                 shock 70 kDa protein 1B 
               
               
                 201631_s_at 
                 3.1092095 
                 up 
                 IER3 
                 immediate early response 3 
               
               
                 202304_at 
                 3.109106 
                 up 
                 FNDC3A 
                 fibronectin type III domain containing 
               
               
                   
                   
                   
                   
                 3A 
               
               
                 223754_at 
                 3.1015599 
                 up 
                 MGC13057 
                 hypothetical protein MGC13057 
               
               
                 219975_x_at 
                 3.0908885 
                 up 
                 OLAH 
                 oleoyl-ACP hydrolase 
               
               
                 218546_at 
                 3.0864964 
                 up 
                 C1orf115 
                 chromosome 1 open reading frame 115 
               
               
                 205935_at 
                 3.0835295 
                 up 
                 FOXF1 
                 forkhead box F1 
               
               
                 229529_at 
                 3.0813122 
                 up 
                 TCF21 
                 transcription factor 21 
               
               
                 228490_at 
                 3.0776792 
                 up 
                 ABHD2 
                 abhydrolase domain containing 2 
               
               
                 206118_at 
                 3.0758493 
                 up 
                 STAT4 
                 signal transducer and activator of 
               
               
                   
                   
                   
                   
                 transcription 4 
               
               
                 219279_at 
                 3.074901 
                 up 
                 DOCK10 
                 dedicator of cytokinesis 10 
               
               
                 222018_at 
                 3.0714924 
                 up 
                 NACA /// 
                 nascent polypeptide-associated 
               
               
                   
                   
                   
                 NACA2 /// 
                 complex alpha subunit /// nascent 
               
               
                   
                   
                   
                 NACAP1 
                 polypeptide-associated complex alpha 
               
               
                   
                   
                   
                   
                 subunit 2 /// nascent-polypeptide- 
               
               
                   
                   
                   
                   
                 associated complex alpha polypeptide 
               
               
                   
                   
                   
                   
                 pseudogene 1 
               
               
                 225842_at 
                 3.0654018 
                 up 
                 PHLDA1 
                 pleckstrin homology-like domain, 
               
               
                   
                   
                   
                   
                 family A, member 1 
               
               
                 1555167_s_at 
                 3.0645018 
                 up 
                 NAMPT 
                 nicotinamide 
               
               
                   
                   
                   
                   
                 phosphoribosyltransferase 
               
               
                 201502_s_at 
                 3.0644495 
                 up 
                 NFKBIA 
                 nuclear factor of kappa light 
               
               
                   
                   
                   
                   
                 polypeptide gene enhancer in B-cells 
               
               
                   
                   
                   
                   
                 inhibitor, alpha 
               
               
                 228195_at 
                 3.054012 
                 up 
                 MGC13057 
                 hypothetical protein MGC13057 
               
               
                 209183_s_at 
                 3.0345566 
                 up 
                 C10orf10 
                 chromosome 10 open reading frame 10 
               
               
                 209833_at 
                 3.0264297 
                 up 
                 CRADD 
                 CASP2 and RIPK1 domain containing 
               
               
                   
                   
                   
                   
                 adaptor with death domain 
               
               
                 204596_s_at 
                 3.0160112 
                 up 
                 STC1 
                 stanniocalcin 1 
               
               
                 204440_at 
                 3.0156825 
                 up 
                 CD83 
                 CD83 molecule 
               
               
                 229461_x_at 
                 3.014515 
                 up 
                 NEGR1 
                 neuronal growth regulator 1 
               
               
                 201041_s_at 
                 3.0053132 
                 up 
                 DUSP1 
                 dual specificity phosphatase 1 
               
               
                 205356_at 
                 3.0039837 
                 up 
                 USP13 
                 ubiquitin specific peptidase 13 
               
               
                   
                   
                   
                   
                 (isopeptidase T-3) 
               
               
                 216316_x_at 
                 2.9982364 
                 up 
                 GK /// GK3P 
                 glycerol kinase /// glycerol kinase 3 
               
               
                   
                   
                   
                   
                 pseudogene 
               
               
                 219257_s_at 
                 2.9839096 
                 up 
                 SPHK1 
                 sphingosine kinase 1 
               
               
                 205239_at 
                 2.983703 
                 up 
                 AREG /// 
                 amphiregulin /// amphiregulin B 
               
               
                   
                   
                   
                 AREGB 
               
               
                 225847_at 
                 2.9832149 
                 up 
                 AADACL1 
                 arylacetamide deacetylase-like 1 
               
               
                 214370_at 
                 2.9802194 
                 up 
                 S100A8 
                 Calcium-binding protein in 
               
               
                   
                   
                   
                   
                 macrophages (MRP-8) macrophage 
               
               
                   
                   
                   
                   
                 migration inhibitory factor (MIF)- 
               
               
                   
                   
                   
                   
                 related protein 
               
               
                 206756_at 
                 2.9774065 
                 up 
                 CHST7 
                 carbohydrate (N-acetylglucosamine 6- 
               
               
                   
                   
                   
                   
                 O) sulfotransferase 7 
               
               
                 213325_at 
                 2.9673648 
                 up 
                 PVRL3 
                 poliovirus receptor-related 3 
               
               
                 220054_at 
                 2.967118 
                 up 
                 IL23A 
                 interleukin 23, alpha subunit p19 
               
               
                 203372_s_at 
                 2.9669046 
                 up 
                 SOCS2 
                 suppressor of cytokine signaling 2 
               
               
                 231899_at 
                 2.9664657 
                 up 
                 ZC3H12C 
                 zinc finger CCCH-type containing 12C 
               
               
                 237215_s_at 
                 2.9501724 
                 up 
                 TFRC 
                 transferrin receptor (p90, CD71) 
               
               
                 227613_at 
                 2.935803 
                 up 
                 ZNF331 
                 zinc finger protein 331 
               
               
                 231944_at 
                 2.9320385 
                 up 
                 ERO1LB 
                 ERO1-like beta ( S. cerevisiae ), mRNA 
               
               
                   
                   
                   
                   
                 (cDNA clone MGC: 26065 
               
               
                   
                   
                   
                   
                 IMAGE: 4829502) 
               
               
                 243296_at 
                 2.9062977 
                 up 
                 NAMPT 
                 G0S9 mRNA, instability elements 
               
               
                 207754_at 
                 2.9039783 
                 up 
                 RASSF8 
                 Ras association (RalGDS/AF-6) 
               
               
                   
                   
                   
                   
                 domain family (N-terminal) member 8 
               
               
                 214681_at 
                 2.8969262 
                 up 
                 GK 
                 glycerol kinase 
               
               
                 225606_at 
                 2.8948586 
                 up 
                 BCL2L11 
                 BCL2-like 11 (apoptosis facilitator) 
               
               
                 229225_at 
                 2.893143 
                 up 
                 NRP2 
                 neuropilin 2 
               
               
                 208962_s_at 
                 2.889333 
                 up 
                 FADS1 
                 fatty acid desaturase 1 
               
               
                 219926_at 
                 2.8884964 
                 up 
                 POPDC3 
                 popeye domain containing 3 
               
               
                 241611_s_at 
                 2.88746 
                 up 
                 FNDC3A 
                 fibronectin type III domain containing 
               
               
                   
                   
                   
                   
                 3A 
               
               
                 227235_at 
                 2.8838294 
                 up 
                 GUCY1A3 
                 guanylate cyclase 1, soluble, alpha 3 
               
               
                 241762_at 
                 2.8783326 
                 up 
                 FBXO32 
                 F-box protein 32 (FBXO32), transcript 
               
               
                   
                   
                   
                   
                 variant 2, mRNA 
               
               
                 236645_at 
                 2.8695679 
                 up 
                 HBP1 
                 HMG-box transcription factor 1 
               
               
                 206618_at 
                 2.864942 
                 up 
                 IL18R1 
                 interleukin 18 receptor 1 
               
               
                 223510_at 
                 2.864709 
                 up 
                 NRP2 
                 neuropilin 2 
               
               
                 208591_s_at 
                 2.851169 
                 up 
                 PDE3B 
                 phosphodiesterase 3B, cGMP-inhibited 
               
               
                 213103_at 
                 2.8436816 
                 up 
                 STARD13 
                 StAR-related lipid transfer (START) 
               
               
                   
                   
                   
                   
                 domain containing 13 
               
               
                 224942_at 
                 2.8339565 
                 up 
                 PAPPA 
                 pregnancy-associated plasma protein 
               
               
                   
                   
                   
                   
                 A, pappalysin 1 
               
               
                 241763_s_at 
                 2.832837 
                 up 
                 FBXO32 
                 F-box protein 32 (FBXO32), transcript 
               
               
                   
                   
                   
                   
                 variant 2, mRNA 
               
               
                 229088_at 
                 2.831386 
                 up 
                 ENPP1 
                 ectonucleotide 
               
               
                   
                   
                   
                   
                 pyrophosphatase/phosphodiesterase 1 
               
               
                 202779_s_at 
                 2.8305142 
                 up 
                 LOC731049 
                 similar to Ubiquitin-conjugating 
               
               
                   
                   
                   
                 /// UBE2S 
                 enzyme E2S (Ubiquitin-conjugating 
               
               
                   
                   
                   
                   
                 enzyme E2-24 kDa) (Ubiquitin-protein 
               
               
                   
                   
                   
                   
                 ligase) (Ubiquitin carrier protein) (E2- 
               
               
                   
                   
                   
                   
                 EPF5) /// ubiquitin-conjugating 
               
               
                   
                   
                   
                   
                 enzyme E2S 
               
               
                 225142_at 
                 2.8252053 
                 up 
                 JHDM1D 
                 jumonji C domain containing histone 
               
               
                   
                   
                   
                   
                 demethylase 1 homolog D ( S. cerevisiae ) 
               
               
                 232825_s_at 
                 2.8207173 
                 up 
                 DSEL 
                 dermatan sulfate epimerase-like 
               
               
                 212092_at 
                 2.8129215 
                 up 
                 PEG10 
                 paternally expressed 10 
               
               
                 1552508_at 
                 2.8024065 
                 up 
                 KCNE4 
                 potassium voltage-gated channel, Isk- 
               
               
                   
                   
                   
                   
                 related family, member 4 
               
               
                 213931_at 
                 2.8021426 
                 up 
                 ID2 /// ID2B 
                 inhibitor of DNA binding 2, dominant 
               
               
                   
                   
                   
                   
                 negative helix-loop-helix protein /// 
               
               
                   
                   
                   
                   
                 inhibitor of DNA binding 2B, 
               
               
                   
                   
                   
                   
                 dominant negative helix-loop-helix 
               
               
                   
                   
                   
                   
                 protein (pseudogene) 
               
               
                 235996_at 
                 2.7879438 
                 up 
                 RASSF8 
                 Ras association (RalGDS/AF-6) 
               
               
                   
                   
                   
                   
                 domain family (N-terminal) member 8 
               
               
                 204457_s_at 
                 2.7829573 
                 up 
                 GAS1 
                 growth arrest-specific 1 
               
               
                 207386_at 
                 2.7815282 
                 up 
                 CYP7B1 
                 cytochrome P450, family 7, subfamily 
               
               
                   
                   
                   
                   
                 B, polypeptide 1 
               
               
                 209406_at 
                 2.773616 
                 up 
                 BAG2 
                 BCL2-associated athanogene 2 
               
               
                 207388_s_at 
                 2.7678204 
                 up 
                 PTGES 
                 prostaglandin E synthase 
               
               
                 204818_at 
                 2.7658327 
                 up 
                 HSD17B2 
                 hydroxysteroid (17-beta) 
               
               
                   
                   
                   
                   
                 dehydrogenase 2 
               
               
                 201108_s_at 
                 2.7555368 
                 up 
                 THBS1 
                 thrombospondin 1 
               
               
                 224229_s_at 
                 2.7508733 
                 up 
                 AKT3 
                 v-akt murine thymoma viral oncogene 
               
               
                   
                   
                   
                   
                 homolog 3 (protein kinase B, gamma) 
               
               
                 235368_at 
                 2.7506857 
                 up 
                 ADAMTS5 
                 ADAM metallopeptidase with 
               
               
                   
                   
                   
                   
                 thrombospondin type 1 motif, 5 
               
               
                 203827_at 
                 2.7443364 
                 up 
                 WIPI1 
                 WD repeat domain, phosphoinositide 
               
               
                   
                   
                   
                   
                 interacting 1 
               
               
                 237867_s_at 
                 2.7432609 
                 up 
                 PID1 
                 phosphotyrosine interaction domain 
               
               
                   
                   
                   
                   
                 containing 1 
               
               
                 206806_at 
                 2.7395847 
                 up 
                 DGKI 
                 diacylglycerol kinase, iota 
               
               
                 224941_at 
                 2.7371583 
                 up 
                 PAPPA 
                 pregnancy-associated plasma protein 
               
               
                   
                   
                   
                   
                 A, pappalysin 1 
               
               
                 231779_at 
                 2.7335684 
                 up 
                 IRAK2 
                 interleukin-1 receptor-associated 
               
               
                   
                   
                   
                   
                 kinase 2 
               
               
                 204038_s_at 
                 2.7315595 
                 up 
                 LPAR1 
                 lysophosphatidic acid receptor 1 
               
               
                 201981_at 
                 2.7272985 
                 up 
                 PAPPA 
                 pregnancy-associated plasma protein 
               
               
                   
                   
                   
                   
                 A, pappalysin 1 
               
               
                 212374_at 
                 2.7260473 
                 up 
                 FEM1B 
                 fem-1 homolog b ( C. elegans ) 
               
               
                 216005_at 
                 2.7193272 
                 up 
                 TNC 
                 Tenascin 
               
               
                 229310_at 
                 2.719125 
                 up 
                 KLHL29 
                 kelch-like 29 ( Drosophila ) 
               
               
                 211958_at 
                 2.7118793 
                 up 
                 IGFBP5 
                 insulin-like growth factor binding 
               
               
                   
                   
                   
                   
                 protein 5 
               
               
                 214702_at 
                 2.7099462 
                 up 
                 FN1 
                 fibronectin 1 
               
               
                 224220_x_at 
                 2.7084796 
                 up 
                 TRPC4 
                 transient receptor potential cation 
               
               
                   
                   
                   
                   
                 channel, subfamily C, member 4 
               
               
                 235723_at 
                 2.706666 
                 up 
                 BNC2 
                 basonuclin 2 
               
               
                 211965_at 
                 2.7050216 
                 up 
                 ZFP36L1 
                 zinc finger protein 36, C3H type-like 1 
               
               
                 225337_at 
                 2.704214 
                 up 
                 ABHD2 
                 abhydrolase domain containing 2 
               
               
                 209070_s_at 
                 2.700427 
                 up 
                 RGS5 
                 regulator of G-protein signaling 5 
               
               
                 1562606_a_at 
                 2.7000384 
                 up 
                 LOC440028 
                 hypothetical gene supported by 
               
               
                   
                   
                   
                   
                 BC040853 
               
               
                 210764_s_at 
                 2.6922395 
                 up 
                 CYR61 
                 cysteine-rich, angiogenic inducer, 61 
               
               
                 222379_at 
                 2.6855981 
                 up 
                 KCNE4 
                 potassium voltage-gated channel, Isk- 
               
               
                   
                   
                   
                   
                 related family, member 4 
               
               
                 205794_s_at 
                 2.6822994 
                 up 
                 NOVA1 
                 neuro-oncological ventral antigen 1 
               
               
                 207535_s_at 
                 2.6700058 
                 up 
                 NFKB2 
                 nuclear factor of kappa light 
               
               
                   
                   
                   
                   
                 polypeptide gene enhancer in B-cells 2 
               
               
                   
                   
                   
                   
                 (p49/p100) 
               
               
                 204015_s_at 
                 2.6682754 
                 up 
                 DUSP4 
                 dual specificity phosphatase 4 
               
               
                 217738_at 
                 2.6675475 
                 up 
                 NAMPT 
                 nicotinamide 
               
               
                   
                   
                   
                   
                 phosphoribosyltransferase 
               
               
                 221569_at 
                 2.6674023 
                 up 
                 AHI1 
                 Abelson helper integration site 1 
               
               
                 236140_at 
                 2.6667895 
                 up 
                 GCLM 
                 glutamate-cysteine ligase, modifier 
               
               
                   
                   
                   
                   
                 subunit 
               
               
                 1554462_a_at 
                 2.6664002 
                 up 
                 DNAJB9 
                 DnaJ (Hsp40) homolog, subfamily B, 
               
               
                   
                   
                   
                   
                 member 9 
               
               
                 212344_at 
                 2.6652708 
                 up 
                 SULF1 
                 sulfatase 1 
               
               
                 202557_at 
                 2.6646934 
                 up 
                 HSPA13 
                 heat shock protein 70 kDa family, 
               
               
                   
                   
                   
                   
                 member 13 
               
               
                 224940_s_at 
                 2.6638696 
                 up 
                 PAPPA 
                 pregnancy-associated plasma protein 
               
               
                   
                   
                   
                   
                 A, pappalysin 1 
               
               
                 220655_at 
                 2.6540391 
                 up 
                 TNIP3 
                 TNFAIP3 interacting protein 3 
               
               
                 216199_s_at 
                 2.6540227 
                 up 
                 MAP3K4 
                 mitogen-activated protein kinase 
               
               
                   
                   
                   
                   
                 kinase kinase 4 
               
               
                 230206_at 
                 2.6534097 
                 up 
                 DOCK5 
                 Dedicator of cytokinesis 5, mRNA 
               
               
                   
                   
                   
                   
                 (cDNA clone IMAGE: 3347029) 
               
               
                 204557_s_at 
                 2.6526718 
                 up 
                 DZIP1 
                 DAZ interacting protein 1 
               
               
                 206390_x_at 
                 2.6515956 
                 up 
                 PF4 
                 platelet factor 4 
               
               
                 226322_at 
                 2.6468246 
                 up 
                 TMTC1 
                 transmembrane and tetratricopeptide 
               
               
                   
                   
                   
                   
                 repeat containing 1 
               
               
                 203925_at 
                 2.6462543 
                 up 
                 GCLM 
                 glutamate-cysteine ligase, modifier 
               
               
                   
                   
                   
                   
                 subunit 
               
               
                 220955_x_at 
                 2.644316 
                 up 
                 RAB23 
                 RAB23, member RAS oncogene 
               
               
                   
                   
                   
                   
                 family 
               
               
                 208322_s_at 
                 2.6438155 
                 up 
                 ST3GAL1 
                 ST3 beta-galactoside alpha-2,3- 
               
               
                   
                   
                   
                   
                 sialyltransferase 1 
               
               
                 225033_at 
                 2.640394 
                 up 
                 ST3GAL1 
                 ST3 beta-galactoside alpha-2,3- 
               
               
                   
                   
                   
                   
                 sialyltransferase 1 
               
               
                 208964_s_at 
                 2.6379926 
                 up 
                 FADS1 
                 fatty acid desaturase 1 
               
               
                 219134_at 
                 2.6371877 
                 up 
                 ELTD1 
                 EGF, latrophilin and seven 
               
               
                   
                   
                   
                   
                 transmembrane domain containing 1 
               
               
                 232504_at 
                 2.6357627 
                 up 
                 LOC285628 
                 hypothetical protein LOC285628 
               
               
                 239163_at 
                 2.6356966 
                 up 
                 UBE2B 
                 ubiquitin-conjugating enzyme E2B 
               
               
                   
                   
                   
                   
                 (RAD6 homolog) 
               
               
                 205924_at 
                 2.6338334 
                 up 
                 RAB3B 
                 RAB3B, member RAS oncogene 
               
               
                   
                   
                   
                   
                 family 
               
               
                 225532_at 
                 2.6329355 
                 up 
                 CABLES1 
                 Cdk5 and Abl enzyme substrate 1 
               
               
                 228785_at 
                 2.6269226 
                 up 
                 ZNF281 
                 Full length insert cDNA clone 
               
               
                   
                   
                   
                   
                 ZE09A11 
               
               
                 1554980_a_at 
                 2.623143 
                 up 
                 ATF3 
                 activating transcription factor 3 
               
               
                 212607_at 
                 2.6224685 
                 up 
                 AKT3 
                 v-akt murine thymoma viral oncogene 
               
               
                   
                   
                   
                   
                 homolog 3 (protein kinase B, gamma) 
               
               
                 227058_at 
                 2.6209402 
                 up 
                 C13orf33 
                 chromosome 13 open reading frame 33 
               
               
                 238649_at 
                 2.6207957 
                 up 
                 PITPNC1 
                 phosphatidylinositol transfer protein, 
               
               
                   
                   
                   
                   
                 cytoplasmic 1 
               
               
                 242163_at 
                 2.6196032 
                 up 
                 THRAP3 
                 thyroid hormone receptor associated 
               
               
                   
                   
                   
                   
                 protein 3 
               
               
                 229947_at 
                 2.618586 
                 up 
                 PI15 
                 peptidase inhibitor 15 
               
               
                 223264_at 
                 2.6175916 
                 up 
                 MESDC1 
                 mesoderm development candidate 1 
               
               
                 242283_at 
                 2.6143296 
                 up 
                 C1orf67 /// 
                 chromosome 1 open reading frame 67 
               
               
                   
                   
                   
                 DNAH14 
                 /// dynein, axonemal, heavy chain 14 
               
               
                 202842_s_at 
                 2.612975 
                 up 
                 DNAJB9 
                 DnaJ (Hsp40) homolog, subfamily B, 
               
               
                   
                   
                   
                   
                 member 9 
               
               
                 214472_at 
                 2.6077855 
                 up 
                 HIST1H2AD 
                 histone cluster 1, H2ad /// histone 
               
               
                   
                   
                   
                 /// 
                 cluster 1, H3a /// histone cluster 1, H3b 
               
               
                   
                   
                   
                 HIST1H3A 
                 /// histone cluster 1, H3c /// histone 
               
               
                   
                   
                   
                 /// HIST1H3B 
                 cluster 1, H3d /// histone cluster 1, H3e 
               
               
                   
                   
                   
                 /// HIST1H3C 
                 /// histone cluster 1, H3f /// histone 
               
               
                   
                   
                   
                 /// 
                 cluster 1, H3g /// histone cluster 1, H3h 
               
               
                   
                   
                   
                 HIST1H3D 
                 /// histone cluster 1, H3i /// histone 
               
               
                   
                   
                   
                 /// HIST1H3E 
                 cluster 1, H3j 
               
               
                   
                   
                   
                 /// HIST1H3F 
               
               
                   
                   
                   
                 /// 
               
               
                   
                   
                   
                 HIST1H3G 
               
               
                   
                   
                   
                 /// 
               
               
                   
                   
                   
                 HIST1H3H 
               
               
                   
                   
                   
                 /// HIST1H3I 
               
               
                   
                   
                   
                 /// HIST1H3J 
               
               
                 218980_at 
                 2.6065404 
                 up 
                 FHOD3 
                 formin homology 2 domain containing 3 
               
               
                 217590_s_at 
                 2.6019518 
                 up 
                 TRPA1 
                 transient receptor potential cation 
               
               
                   
                   
                   
                   
                 channel, subfamily A, member 1 
               
               
                 211756_at 
                 2.5990396 
                 up 
                 PTHLH 
                 parathyroid hormone-like hormone 
               
               
                 227080_at 
                 2.5989056 
                 up 
                 ZNF697 
                 zinc finger protein 697 
               
               
                 220346_at 
                 2.5971677 
                 up 
                 MTHFD2L 
                 methylenetetrahydrofolate 
               
               
                   
                   
                   
                   
                 dehydrogenase (NADP+ dependent) 2- 
               
               
                   
                   
                   
                   
                 like 
               
               
                 221942_s_at 
                 2.5942783 
                 up 
                 GUCY1A3 
                 guanylate cyclase 1, soluble, alpha 3 
               
               
                 205825_at 
                 2.5902019 
                 up 
                 PCSK1 
                 proprotein convertase subtilisin/kexin 
               
               
                   
                   
                   
                   
                 type 1 
               
               
                 222945_x_at 
                 2.5855827 
                 up 
                 OLAH 
                 oleoyl-ACP hydrolase 
               
               
                 226931_at 
                 2.5830119 
                 up 
                 TMTC1 
                 transmembrane and tetratricopeptide 
               
               
                   
                   
                   
                   
                 repeat containing 1 
               
               
                 241765_at 
                 2.5736842 
                 up 
                 CPM 
                 carboxypeptidase M 
               
               
                 230237_at 
                 2.5733738 
                 up 
                 ADCYAP1 
                 adenylate cyclase activating 
               
               
                   
                   
                   
                   
                 polypeptide 1 (pituitary) 
               
               
                 209808_x_at 
                 2.5724812 
                 up 
                 ING1 
                 inhibitor of growth family, member 1 
               
               
                 227945_at 
                 2.5660486 
                 up 
                 TBC1D1 
                 TBC1 (tre-2/USP6, BUB2, cdc16) 
               
               
                   
                   
                   
                   
                 domain family, member 1 
               
               
                 214446_at 
                 2.5570273 
                 up 
                 ELL2 
                 elongation factor, RNA polymerase II, 2 
               
               
                 221782_at 
                 2.5525873 
                 up 
                 DNAJC10 
                 DnaJ (Hsp40) homolog, subfamily C, 
               
               
                   
                   
                   
                   
                 member 10 
               
               
                 223058_at 
                 2.5435784 
                 up 
                 FAM107B 
                 family with sequence similarity 107, 
               
               
                   
                   
                   
                   
                 member B 
               
               
                 202213_s_at 
                 2.5383074 
                 up 
                 CUL4B 
                 cullin 4B 
               
               
                 237106_at 
                 2.5334878 
                 up 
                 SLC11A2 
                 NRAMP2 
               
               
                 235927_at 
                 2.5293667 
                 up 
                 XPO1 
                 exportin 1 (CRM1 homolog, yeast) 
               
               
                 230494_at 
                 2.5260012 
                 up 
                 SLC20A1 
                 Solute carrier family 20 (phosphate 
               
               
                   
                   
                   
                   
                 transporter), member 1, mRNA (cDNA 
               
               
                   
                   
                   
                   
                 clone MGC: 8767 IMAGE: 3918690) 
               
               
                 204897_at 
                 2.5254738 
                 up 
                 PTGER4 
                 prostaglandin E receptor 4 (subtype 
               
               
                   
                   
                   
                   
                 EP4) 
               
               
                 214469_at 
                 2.5204768 
                 up 
                 HIST1H2AB 
                 histone cluster 1, H2ab /// histone 
               
               
                   
                   
                   
                 /// 
                 cluster 1, H2ae 
               
               
                   
                   
                   
                 HIST1H2AE 
               
               
                 204472_at 
                 2.5198975 
                 up 
                 GEM 
                 GTP binding protein overexpressed in 
               
               
                   
                   
                   
                   
                 skeletal muscle 
               
               
                 206026_s_at 
                 2.519742 
                 up 
                 TNFAIP6 
                 tumor necrosis factor, alpha-induced 
               
               
                   
                   
                   
                   
                 protein 6 
               
               
                 210367_s_at 
                 2.5187645 
                 up 
                 PTGES 
                 prostaglandin E synthase 
               
               
                 217996_at 
                 2.5148838 
                 up 
                 PHLDA1 
                 pleckstrin homology-like domain, 
               
               
                   
                   
                   
                   
                 family A, member 1 
               
               
                 227123_at 
                 2.5144148 
                 up 
                 RAB3B 
                 Small GTP binding protein RAB3B 
               
               
                   
                   
                   
                   
                 (RAB3B) 
               
               
                 208885_at 
                 2.5127752 
                 up 
                 LCP1 
                 lymphocyte cytosolic protein 1 (L- 
               
               
                   
                   
                   
                   
                 plastin) 
               
               
                 214254_at 
                 2.5125573 
                 up 
                 MAGEA4 
                 melanoma antigen family A, 4 
               
               
                 226886_at 
                 2.512313 
                 up 
                 GFPT1 
                 glutamine-fructose-6-phosphate 
               
               
                   
                   
                   
                   
                 transaminase 1 
               
               
                 205566_at 
                 2.5082593 
                 up 
                 ABHD2 
                 abhydrolase domain containing 2 
               
               
                 221781_s_at 
                 2.5082314 
                 up 
                 DNAJC10 
                 DnaJ (Hsp40) homolog, subfamily C, 
               
               
                   
                   
                   
                   
                 member 10 
               
               
                 1554741_s_at 
                 2.5060341 
                 up 
                 FGF7 /// 
                 fibroblast growth factor 7 (keratinocyte 
               
               
                   
                   
                   
                 KGFLP1 /// 
                 growth factor) /// keratinocyte growth 
               
               
                   
                   
                   
                 KGFLP2 
                 factor-like protein 1 /// keratinocyte 
               
               
                   
                   
                   
                   
                 growth factor-like protein 2 
               
               
                 206300_s_at 
                 2.5052757 
                 up 
                 PTHLH 
                 parathyroid hormone-like hormone 
               
               
                 206805_at 
                 2.5045469 
                 up 
                 SEMA3A 
                 sema domain, immunoglobulin domain 
               
               
                   
                   
                   
                   
                 (Ig), short basic domain, secreted, 
               
               
                   
                   
                   
                   
                 (semaphorin) 3A 
               
               
                 202052_s_at 
                 2.5033193 
                 up 
                 RAI14 
                 retinoic acid induced 14 
               
               
                 213993_at 
                 2.499253 
                 up 
                 SPON1 
                 spondin 1, extracellular matrix protein 
               
               
                 209897_s_at 
                 2.4991436 
                 up 
                 SLIT2 
                 slit homolog 2 ( Drosophila ) 
               
               
                 229530_at 
                 2.498387 
                 up 
                 GUCY1A3 
                 guanylate cyclase 1, soluble, alpha 3 
               
               
                 215285_s_at 
                 2.4979303 
                 up 
                 PHTF1 
                 putative homeodomain transcription 
               
               
                   
                   
                   
                   
                 factor 1 
               
               
                 218615_s_at 
                 2.4974163 
                 up 
                 TMEM39A 
                 transmembrane protein 39A 
               
               
                 220615_s_at 
                 2.4965284 
                 up 
                 FAR2 
                 fatty acyl CoA reductase 2 
               
               
                 205303_at 
                 2.49271 
                 up 
                 KCNJ8 
                 potassium inwardly-rectifying channel, 
               
               
                   
                   
                   
                   
                 subfamily J, member 8 
               
               
                 222735_at 
                 2.4891634 
                 up 
                 TMEM38B 
                 transmembrane protein 38B 
               
               
                 209501_at 
                 2.487513 
                 up 
                 CDR2 
                 cerebellar degeneration-related protein 
               
               
                   
                   
                   
                   
                 2, 62 kDa 
               
               
                 205767_at 
                 2.486593 
                 up 
                 EREG 
                 epiregulin 
               
               
                 205830_at 
                 2.4858525 
                 up 
                 CLGN 
                 calmegin 
               
               
                 228128_x_at 
                 2.4817405 
                 up 
                 PAPPA 
                 pregnancy-associated plasma protein 
               
               
                   
                   
                   
                   
                 A, pappalysin 1 
               
               
                 229256_at 
                 2.4780662 
                 up 
                 PGM2L1 
                 phosphoglucomutase 2-like 1 
               
               
                 223059_s_at 
                 2.4761326 
                 up 
                 FAM107B 
                 family with sequence similarity 107, 
               
               
                   
                   
                   
                   
                 member B 
               
               
                 228551_at 
                 2.473978 
                 up 
                 DENND5B 
                 DENN/MADD domain containing 5B 
               
               
                 205098_at 
                 2.4739516 
                 up 
                 CCR1 
                 chemokine (C-C motif) receptor 1 
               
               
                 220272_at 
                 2.4710832 
                 up 
                 BNC2 
                 basonuclin 2 
               
               
                 212975_at 
                 2.4708278 
                 up 
                 DENND3 
                 DENN/MADD domain containing 3 
               
               
                 222690_s_at 
                 2.469726 
                 up 
                 TMEM39A 
                 transmembrane protein 39A 
               
               
                 203239_s_at 
                 2.4657195 
                 up 
                 CNOT3 
                 CCR4-NOT transcription complex, 
               
               
                   
                   
                   
                   
                 subunit 3 
               
               
                 203823_at 
                 2.4619107 
                 up 
                 RGS3 
                 regulator of G-protein signaling 3 
               
               
                 203373_at 
                 2.4602883 
                 up 
                 SOCS2 
                 suppressor of cytokine signaling 2 
               
               
                 210692_s_at 
                 2.456732 
                 up 
                 SLC43A3 
                 solute carrier family 43, member 3 
               
               
                 205139_s_at 
                 2.4541962 
                 up 
                 UST 
                 uronyl-2-sulfotransferase 
               
               
                 220145_at 
                 2.4529 
                 up 
                 MAP9 
                 microtubule-associated protein 9 
               
               
                 226743_at 
                 2.451173 
                 up 
                 SLFN11 
                 schlafen family member 11 
               
               
                 219093_at 
                 2.4472542 
                 up 
                 PID1 
                 phosphotyrosine interaction domain 
               
               
                   
                   
                   
                   
                 containing 1 
               
               
                 213112_s_at 
                 2.4471107 
                 up 
                 SQSTM1 
                 sequestosome 1 
               
               
                 219228_at 
                 2.4418485 
                 up 
                 ZNF331 
                 zinc finger protein 331 
               
               
                 1554110_at 
                 2.4401536 
                 up 
                 CDCP1 
                 CUB domain containing protein 1 
               
               
                 217649_at 
                 2.4384716 
                 up 
                 ZFAND5 
                 zinc finger, AN1-type domain 5 
               
               
                 226804_at 
                 2.4369545 
                 up 
                 FAM20A 
                 family with sequence similarity 20, 
               
               
                   
                   
                   
                   
                 member A 
               
               
                 243403_x_at 
                 2.4360526 
                 up 
                 CPM 
                 carboxypeptidase M 
               
               
                 214701_s_at 
                 2.4357622 
                 up 
                 FN1 
                 fibronectin 1 
               
               
                 207522_s_at 
                 2.434122 
                 up 
                 ATP2A3 
                 ATPase, Ca++ transporting, ubiquitous 
               
               
                 219117_s_at 
                 2.4314268 
                 up 
                 FKBP11 
                 FK506 binding protein 11, 19 kDa 
               
               
                 211840_s_at 
                 2.4287648 
                 up 
                 PDE4D 
                 phosphodiesterase 4D, cAMP-specific 
               
               
                   
                   
                   
                   
                 (phosphodiesterase E3 dunce homolog, 
               
               
                   
                   
                   
                   
                   Drosophila ) 
               
               
                 239001_at 
                 2.428258 
                 up 
                 MGST1 
                 Microsomal glutathione S-transferase 1 
               
               
                   
                   
                   
                   
                 (MGST1), transcript variant 1d, 
               
               
                   
                   
                   
                   
                 mRNA 
               
               
                 219427_at 
                 2.4277742 
                 up 
                 FAT4 
                 FAT tumor suppressor homolog 4 
               
               
                   
                   
                   
                   
                 ( Drosophila ) 
               
               
                 228540_at 
                 2.426083 
                 up 
                 QKI 
                 quaking homolog, KH domain RNA 
               
               
                   
                   
                   
                   
                 binding (mouse) 
               
               
                 205547_s_at 
                 2.4258394 
                 up 
                 TAGLN 
                 transgelin 
               
               
                 214375_at 
                 2.425571 
                 up 
                 LOC729222 
                 similar to mKIAA1230 protein /// 
               
               
                   
                   
                   
                 /// PPFIBP1 
                 PTPRF interacting protein, binding 
               
               
                   
                   
                   
                   
                 protein 1 (liprin beta 1) 
               
               
                 204037_at 
                 2.4254246 
                 up 
                 LPAR1 
                 lysophosphatidic acid receptor 1 
               
               
                 213704_at 
                 2.4229991 
                 up 
                 RABGGTB 
                 Rab geranylgeranyltransferase, beta 
               
               
                   
                   
                   
                   
                 subunit 
               
               
                 219118_at 
                 2.422199 
                 up 
                 FKBP11 
                 FK506 binding protein 11, 19 kDa 
               
               
                 225582_at 
                 2.4213138 
                 up 
                 ITPRIP 
                 inositol 1,4,5-triphosphate receptor 
               
               
                   
                   
                   
                   
                 interacting protein 
               
               
                 229307_at 
                 2.4208326 
                 up 
                 ANKRD28 
                 ankyrin repeat domain 28 
               
               
                 214290_s_at 
                 2.4204948 
                 up 
                 HIST2H2AA3 
                 histone cluster 2, H2aa3 /// histone 
               
               
                   
                   
                   
                 /// 
                 cluster 2, H2aa4 
               
               
                   
                   
                   
                 HIST2H2AA4 
               
               
                 201739_at 
                 2.4191535 
                 up 
                 SGK1 
                 serum/glucocorticoid regulated kinase 1 
               
               
                 239336_at 
                 2.4168572 
                 up 
                 THBS1 
                 (clone lambda-TS-33) thrombospondin 
               
               
                   
                   
                   
                   
                 (THBS) mRNA, 5′ end 
               
               
                 1559400_s_at 
                 2.4151716 
                 up 
                 PAPPA 
                 pregnancy-associated plasma protein 
               
               
                   
                   
                   
                   
                 A, pappalysin 1 
               
               
                 205066_s_at 
                 2.4135945 
                 up 
                 ENPP1 
                 ectonucleotide 
               
               
                   
                   
                   
                   
                 pyrophosphatase/phosphodiesterase 1 
               
               
                 220034_at 
                 2.4113884 
                 up 
                 IRAK3 
                 interleukin-1 receptor-associated 
               
               
                   
                   
                   
                   
                 kinase 3 
               
               
                 208963_x_at 
                 2.4111784 
                 up 
                 FADS1 
                 fatty acid desaturase 1 
               
               
                 213496_at 
                 2.4059057 
                 up 
                 LPPR4 
                 plasticity related gene 1 
               
               
                 205453_at 
                 2.4039452 
                 up 
                 HOXB2 
                 homeobox B2 
               
               
                 205119_s_at 
                 2.4022236 
                 up 
                 FPR1 
                 formyl peptide receptor 1 
               
               
                 232224_at 
                 2.4019115 
                 up 
                 MASP1 
                 mannan-binding lectin serine peptidase 
               
               
                   
                   
                   
                   
                 1 (C4/C2 activating component of Ra- 
               
               
                   
                   
                   
                   
                 reactive factor) 
               
               
                 202392_s_at 
                 2.40164 
                 up 
                 PISD 
                 phosphatidylserine decarboxylase 
               
               
                 212906_at 
                 2.4009886 
                 up 
                 GRAMD1B 
                 GRAM domain containing 1B, mRNA 
               
               
                   
                   
                   
                   
                 (cDNA clone IMAGE: 3854666) 
               
               
                 218801_at 
                 2.4000664 
                 up 
                 UGCGL2 
                 UDP-glucose ceramide 
               
               
                   
                   
                   
                   
                 glucosyltransferase-like 2 
               
               
                 212122_at 
                 2.3983467 
                 up 
                 RHOQ 
                 ras homolog gene family, member Q 
               
               
                 220153_at 
                 2.3949509 
                 up 
                 ENTPD7 
                 ectonucleoside triphosphate 
               
               
                   
                   
                   
                   
                 diphosphohydrolase 7 
               
               
                 204036_at 
                 2.3905594 
                 up 
                 LPAR1 
                 lysophosphatidic acid receptor 1 
               
               
                 228461_at 
                 2.3892233 
                 up 
                 SH3RF3 
                 SH3 domain containing ring finger 3 
               
               
                 205304_s_at 
                 2.3868387 
                 up 
                 KCNJ8 
                 potassium inwardly-rectifying channel, 
               
               
                   
                   
                   
                   
                 subfamily J, member 8 
               
               
                 212350_at 
                 2.386301 
                 up 
                 TBC1D1 
                 TBC1 (tre-2/USP6, BUB2, cdc16) 
               
               
                   
                   
                   
                   
                 domain family, member 1 
               
               
                 205003_at 
                 2.3832471 
                 up 
                 DOCK4 
                 dedicator of cytokinesis 4 
               
               
                 235339_at 
                 2.376645 
                 up 
                 SETDB2 
                 SET domain, bifurcated 2 
               
               
                 220012_at 
                 2.3763833 
                 up 
                 ERO1LB 
                 ERO1-like beta ( S. cerevisiae ) 
               
               
                 44783_s_at 
                 2.3720322 
                 up 
                 HEY1 
                 hairy/enhancer-of-split related with 
               
               
                   
                   
                   
                   
                 YRPW motif 1 
               
               
                 1554290_at 
                 2.3719432 
                 up 
                 HERC3 
                 hect domain and RLD 3 
               
               
                 1570351_at 
                 2.370291 
                 up 
                 ADAMTS6 
                 ADAM metallopeptidase with 
               
               
                   
                   
                   
                   
                 thrombospondin type 1 motif, 6 
               
               
                 204222_s_at 
                 2.3661144 
                 up 
                 GLIPR1 
                 GLI pathogenesis-related 1 
               
               
                 222880_at 
                 2.3649035 
                 up 
                 AKT3 
                 v-akt murine thymoma viral oncogene 
               
               
                   
                   
                   
                   
                 homolog 3 (protein kinase B, gamma) 
               
               
                 235593_at 
                 2.3646154 
                 up 
                 LOC100128821 
                 hypothetical protein LOC100128821 /// 
               
               
                   
                   
                   
                 /// ZEB2 
                 zinc finger E-box binding homeobox 2 
               
               
                 232263_at 
                 2.3646133 
                 up 
                 SLC6A15 
                 solute carrier family 6 (neutral amino 
               
               
                   
                   
                   
                   
                 acid transporter), member 15 
               
               
                 1552701_a_at 
                 2.3634586 
                 up 
                 CARD16 
                 caspase recruitment domain family, 
               
               
                   
                   
                   
                   
                 member 16 
               
               
                 224807_at 
                 2.3633232 
                 up 
                 GRAMD1A 
                 GRAM domain containing 1A 
               
               
                 204470_at 
                 2.362897 
                 up 
                 CXCL1 
                 chemokine (C—X—C motif) ligand 1 
               
               
                   
                   
                   
                   
                 (melanoma growth stimulating activity, 
               
               
                   
                   
                   
                   
                 alpha) 
               
               
                 230263_s_at 
                 2.3622723 
                 up 
                 DOCK5 
                 Dedicator of cytokinesis 5, mRNA 
               
               
                   
                   
                   
                   
                 (cDNA clone IMAGE: 3347029) 
               
               
                 213035_at 
                 2.3611116 
                 up 
                 ANKRD28 
                 ankyrin repeat domain 28 
               
               
                 202986_at 
                 2.3609338 
                 up 
                 ARNT2 
                 aryl-hydrocarbon receptor nuclear 
               
               
                   
                   
                   
                   
                 translocator 2 
               
               
                 209437_s_at 
                 2.3600132 
                 up 
                 SPON1 
                 spondin 1, extracellular matrix protein 
               
               
                 206613_s_at 
                 2.3585851 
                 up 
                 TAF1A 
                 TATA box binding protein (TBP)- 
               
               
                   
                   
                   
                   
                 associated factor, RNA polymerase I, 
               
               
                   
                   
                   
                   
                 A, 48 kDa 
               
               
                 242079_at 
                 2.357697 
                 up 
                 RGS12 
                 regulator of G-protein signaling 12 
               
               
                 211924_s_at 
                 2.3567264 
                 up 
                 PLAUR 
                 plasminogen activator, urokinase 
               
               
                   
                   
                   
                   
                 receptor 
               
               
                 203836_s_at 
                 2.3556855 
                 up 
                 MAP3K5 
                 mitogen-activated protein kinase 
               
               
                   
                   
                   
                   
                 kinase kinase 5 
               
               
                 1555471_a_at 
                 2.354568 
                 up 
                 FMN2 
                 formin 2 
               
               
                 201042_at 
                 2.3514817 
                 up 
                 TGM2 
                 transglutaminase 2 (C polypeptide, 
               
               
                   
                   
                   
                   
                 protein-glutamine-gamma- 
               
               
                   
                   
                   
                   
                 glutamyltransferase) 
               
               
                 223217_s_at 
                 2.3498836 
                 up 
                 NFKBIZ 
                 nuclear factor of kappa light 
               
               
                   
                   
                   
                   
                 polypeptide gene enhancer in B-cells 
               
               
                   
                   
                   
                   
                 inhibitor, zeta 
               
               
                 1555103_s_at 
                 2.3495677 
                 up 
                 FGF7 
                 fibroblast growth factor 7 (keratinocyte 
               
               
                   
                   
                   
                   
                 growth factor) 
               
               
                 221815_at 
                 2.3482256 
                 up 
                 ABHD2 
                 abhydrolase domain containing 2 
               
               
                 1558143_a_at 
                 2.346621 
                 up 
                 BCL2L11 
                 BCL2-like 11 (apoptosis facilitator) 
               
               
                 223774_at 
                 2.3389745 
                 up 
                 SNHG12 
                 small nucleolar RNA host gene 12 
               
               
                   
                   
                   
                   
                 (non-protein coding) 
               
               
                 1553194_at 
                 2.3387334 
                 up 
                 NEGR1 
                 neuronal growth regulator 1 
               
               
                 231015_at 
                 2.3381798 
                 up 
                 KLF15 
                 Kruppel-like factor 15 
               
               
                 1552578_a_at 
                 2.337757 
                 up 
                 MYO3B 
                 myosin IIIB 
               
               
                 202340_x_at 
                 2.33773 
                 up 
                 NR4A1 
                 nuclear receptor subfamily 4, group A, 
               
               
                   
                   
                   
                   
                 member 1 
               
               
                 202609_at 
                 2.334194 
                 up 
                 EPS8 
                 epidermal growth factor receptor 
               
               
                   
                   
                   
                   
                 pathway substrate 8 
               
               
                 210941_at 
                 2.333396 
                 up 
                 PCDH7 
                 protocadherin 7 
               
               
                 203921_at 
                 2.331509 
                 up 
                 CHST2 
                 carbohydrate (N-acetylglucosamine-6- 
               
               
                   
                   
                   
                   
                 O) sulfotransferase 2 
               
               
                 1562102_at 
                 2.3314924 
                 up 
                 AKR1C1 
                 Aldo-keto reductase family 1, member 
               
               
                   
                   
                   
                   
                 C1 (dihydrodiol dehydrogenase 1; 20- 
               
               
                   
                   
                   
                   
                 alpha (3-alpha)-hydroxysteroid 
               
               
                   
                   
                   
                   
                 dehydrogenase), mRNA (cDNA clone 
               
               
                   
                   
                   
                   
                 MGC: 42600 IMAGE: 4825338) 
               
               
                 222305_at 
                 2.3291554 
                 up 
                 HK2 
                 hexokinase 2 
               
               
                 217310_s_at 
                 2.3269384 
                 up 
                 FOXJ3 
                 forkhead box J3 
               
               
                 205128_x_at 
                 2.326936 
                 up 
                 PTGS1 
                 prostaglandin-endoperoxide synthase 1 
               
               
                   
                   
                   
                   
                 (prostaglandin G/H synthase and 
               
               
                   
                   
                   
                   
                 cyclooxygenase) 
               
               
                 238989_at 
                 2.326773 
                 up 
                 C1GALT1C1 
                 C1GALT1-specific chaperone 1 
               
               
                 235770_at 
                 2.3237767 
                 up 
                 MASP1 
                 mannan-binding lectin serine peptidase 
               
               
                   
                   
                   
                   
                 1 (C4/C2 activating component of Ra- 
               
               
                   
                   
                   
                   
                 reactive factor) 
               
               
                 226103_at 
                 2.3234518 
                 up 
                 NEXN 
                 nexilin (F actin binding protein) 
               
               
                 220841_s_at 
                 2.3223662 
                 up 
                 AHI1 
                 Abelson helper integration site 1 
               
               
                 228817_at 
                 2.3209872 
                 up 
                 ALG9 
                 asparagine-linked glycosylation 9, 
               
               
                   
                   
                   
                   
                 alpha-1,2-mannosyltransferase 
               
               
                   
                   
                   
                   
                 homolog ( S. cerevisiae ) 
               
               
                 227688_at 
                 2.318034 
                 up 
                 LRCH2 
                 leucine-rich repeats and calponin 
               
               
                   
                   
                   
                   
                 homology (CH) domain containing 2 
               
               
                 236290_at 
                 2.3161294 
                 up 
                 DOK6 
                 docking protein 6 
               
               
                 222736_s_at 
                 2.3157086 
                 up 
                 TMEM38B 
                 transmembrane protein 38B 
               
               
                 229584_at 
                 2.3139408 
                 up 
                 LRRK2 
                 leucine-rich repeat kinase 2 
               
               
                 203414_at 
                 2.313451 
                 up 
                 MMD 
                 monocyte to macrophage 
               
               
                   
                   
                   
                   
                 differentiation-associated 
               
               
                 207570_at 
                 2.312389 
                 up 
                 SHOX 
                 short stature homeobox 
               
               
                 205214_at 
                 2.3090763 
                 up 
                 STK17B 
                 serine/threonine kinase 17b 
               
               
                 207630_s_at 
                 2.3087645 
                 up 
                 CREM 
                 cAMP responsive element modulator 
               
               
                 207237_at 
                 2.3084404 
                 up 
                 KCNA3 
                 potassium voltage-gated channel, 
               
               
                   
                   
                   
                   
                 shaker-related subfamily, member 3 
               
               
                 228699_at 
                 2.3063605 
                 up 
                 NRP2 
                 Vascular endothelial cell growth factor 
               
               
                   
                   
                   
                   
                 165 receptor 2 (VEGF165R2) 
               
               
                 215813_s_at 
                 2.3061419 
                 up 
                 PTGS1 
                 prostaglandin-endoperoxide synthase 1 
               
               
                   
                   
                   
                   
                 (prostaglandin G/H synthase and 
               
               
                   
                   
                   
                   
                 cyclooxygenase) 
               
               
                 209180_at 
                 2.3054507 
                 up 
                 RABGGTB 
                 Rab geranylgeranyltransferase, beta 
               
               
                   
                   
                   
                   
                 subunit 
               
               
                 218696_at 
                 2.3052793 
                 up 
                 EIF2AK3 
                 eukaryotic translation initiation factor 
               
               
                   
                   
                   
                   
                 2-alpha kinase 3 
               
               
                 223370_at 
                 2.302342 
                 up 
                 PLEKHA3 
                 pleckstrin homology domain 
               
               
                   
                   
                   
                   
                 containing, family A (phosphoinositide 
               
               
                   
                   
                   
                   
                 binding specific) member 3 
               
               
                 205100_at 
                 2.2997909 
                 up 
                 GFPT2 
                 glutamine-fructose-6-phosphate 
               
               
                   
                   
                   
                   
                 transaminase 2 
               
               
                 212609_s_at 
                 2.2997367 
                 up 
                 AKT3 
                 Clones 23920 and 23921 mRNA 
               
               
                   
                   
                   
                   
                 sequence 
               
               
                 1555281_x_at 
                 2.2991943 
                 up 
                 ARMC8 
                 armadillo repeat containing 8 
               
               
                 204944_at 
                 2.2989373 
                 up 
                 PTPRG 
                 protein tyrosine phosphatase, receptor 
               
               
                   
                   
                   
                   
                 type, G 
               
               
                 229438_at 
                 2.2988055 
                 up 
                 LOC100132244 
                 CDNA: FLJ22487 fis, clone 
               
               
                   
                   
                   
                   
                 HRC10931 
               
               
                 212902_at 
                 2.298442 
                 up 
                 SEC24A 
                 SEC24 family, member A ( S. cerevisiae ) 
               
               
                 224826_at 
                 2.2983568 
                 up 
                 RP5- 
                 hypothetical protein KIAA1434 
               
               
                   
                   
                   
                 1022P6.2 
               
               
                 218772_x_at 
                 2.296167 
                 up 
                 TMEM38B 
                 transmembrane protein 38B 
               
               
                 241372_at 
                 2.2959862 
                 up 
                 ZC3H6 
                 zinc finger CCCH-type containing 6 
               
               
                 229555_at 
                 2.295903 
                 up 
                 GALNT5 
                 UDP-N-acetyl-alpha-D- 
               
               
                   
                   
                   
                   
                 galactosamine:polypeptide N- 
               
               
                   
                   
                   
                   
                 acetylgalactosaminyltransferase 5 
               
               
                   
                   
                   
                   
                 (GalNAc-T5) 
               
               
                 202375_at 
                 2.295754 
                 up 
                 SEC24D 
                 SEC24 family, member D ( S. cerevisiae ) 
               
               
                 1559582_at 
                 2.2931254 
                 up 
                 RHOQ 
                 ras homolog gene family, member Q 
               
               
                 1555279_at 
                 2.29071 
                 up 
                 ARMC8 
                 armadillo repeat containing 8 
               
               
                 203475_at 
                 2.2897353 
                 up 
                 CYP19A1 
                 cytochrome P450, family 19, 
               
               
                   
                   
                   
                   
                 subfamily A, polypeptide 1 
               
               
                 204984_at 
                 2.2885683 
                 up 
                 GPC4 
                 glypican 4 
               
               
                 1560007_at 
                 2.28589 
                 up 
                 LOC645984 
                 hypothetical LOC645984 
               
               
                 235236_at 
                 2.2848015 
                 up 
                 LOC100131897 
                 Uncharacterized protein 
               
               
                   
                   
                   
                   
                 LOC100131897 (LOC100131897), 
               
               
                   
                   
                   
                   
                 mRNA 
               
               
                 1559060_a_at 
                 2.2843337 
                 up 
                 FNIP1 
                 MRNA; cDNA DKFZp451A064 (from 
               
               
                   
                   
                   
                   
                 clone DKFZp451A064) 
               
               
                 204089_x_at 
                 2.283146 
                 up 
                 MAP3K4 
                 mitogen-activated protein kinase 
               
               
                   
                   
                   
                   
                 kinase kinase 4 
               
               
                 227621_at 
                 2.2817085 
                 up 
                 WTAP 
                 Wilms tumor 1 associated protein 
               
               
                   
                   
                   
                   
                 (WTAP), transcript variant 2, mRNA 
               
               
                 203498_at 
                 2.2808936 
                 up 
                 RCAN2 
                 regulator of calcineurin 2 
               
               
                 230207_s_at 
                 2.2794304 
                 up 
                 DOCK5 
                 Dedicator of cytokinesis 5, mRNA 
               
               
                   
                   
                   
                   
                 (cDNA clone IMAGE: 3347029) 
               
               
                 213425_at 
                 2.2791493 
                 up 
                 WNT5A 
                 wingless-type MMTV integration site 
               
               
                   
                   
                   
                   
                 family, member 5A 
               
               
                 220745_at 
                 2.2776432 
                 up 
                 IL19 
                 interleukin 19 
               
               
                 235338_s_at 
                 2.2773378 
                 up 
                 SETDB2 
                 SET domain, bifurcated 2 
               
               
                 200790_at 
                 2.2756164 
                 up 
                 ODC1 
                 ornithine decarboxylase 1 
               
               
                 218280_x_at 
                 2.2754815 
                 up 
                 HIST2H2AA3 
                 histone cluster 2, H2aa3 /// histone 
               
               
                   
                   
                   
                 /// 
                 cluster 2, H2aa4 
               
               
                   
                   
                   
                 HIST2H2AA4 
               
               
                 204720_s_at 
                 2.2753987 
                 up 
                 DNAJC6 
                 DnaJ (Hsp40) homolog, subfamily C, 
               
               
                   
                   
                   
                   
                 member 6 
               
               
                 202820_at 
                 2.2720664 
                 up 
                 AHR 
                 aryl hydrocarbon receptor 
               
               
                 228423_at 
                 2.270422 
                 up 
                 MAP9 
                 microtubule-associated protein 9 
               
               
                 203424_s_at 
                 2.2697344 
                 up 
                 IGFBP5 
                 insulin-like growth factor binding 
               
               
                   
                   
                   
                   
                 protein 5 
               
               
                 221918_at 
                 2.2681808 
                 up 
                 PCTK2 
                 PCTAIRE protein kinase 2 
               
               
                 238877_at 
                 2.2665446 
                 up 
                 EYA4 
                 eyes absent homolog 4 ( Drosophila ) 
               
               
                 202721_s_at 
                 2.2655363 
                 up 
                 GFPT1 
                 glutamine-fructose-6-phosphate 
               
               
                   
                   
                   
                   
                 transaminase 1 
               
               
                 213159_at 
                 2.265123 
                 up 
                 PCNX 
                 pecanex homolog ( Drosophila ) 
               
               
                 203837_at 
                 2.2618065 
                 up 
                 MAP3K5 
                 mitogen-activated protein kinase 
               
               
                   
                   
                   
                   
                 kinase kinase 5 
               
               
                 244808_at 
                 2.2614517 
                 up 
                 GRAMD1A 
                 GRAM domain containing 1A, mRNA 
               
               
                   
                   
                   
                   
                 (cDNA clone IMAGE: 5921205) 
               
               
                 222802_at 
                 2.2602103 
                 up 
                 EDN1 
                 endothelin 1 
               
               
                 202722_s_at 
                 2.2597966 
                 up 
                 GFPT1 
                 glutamine-fructose-6-phosphate 
               
               
                   
                   
                   
                   
                 transaminase 1 
               
               
                 228368_at 
                 2.2592928 
                 up 
                 ARHGAP20 
                 Rho GTPase activating protein 20 
               
               
                 228653_at 
                 2.2589445 
                 up 
                 SAMD5 
                 sterile alpha motif domain containing 5 
               
               
                 224455_s_at 
                 2.2587087 
                 up 
                 ADPGK 
                 ADP-dependent glucokinase 
               
               
                 1570515_a_at 
                 2.258047 
                 up 
                 FILIP1 
                 filamin A interacting protein 1 
               
               
                 44790_s_at 
                 2.257748 
                 up 
                 C13orf18 /// 
                 chromosome 13 open reading frame 18 
               
               
                   
                   
                   
                 LOC728970 
                 /// hypothetical LOC728970 
               
               
                 213836_s_at 
                 2.2555509 
                 up 
                 WIPI1 
                 WD repeat domain, phosphoinositide 
               
               
                   
                   
                   
                   
                 interacting 1 
               
               
                 225589_at 
                 2.254314 
                 up 
                 SH3RF1 
                 SH3 domain containing ring finger 1 
               
               
                 209545_s_at 
                 2.2526133 
                 up 
                 RIPK2 
                 receptor-interacting serine-threonine 
               
               
                   
                   
                   
                   
                 kinase 2 
               
               
                 1556113_at 
                 2.2524776 
                 up 
                 DKFZp451A211 
                 DKFZp451A211 protein 
               
               
                 206249_at 
                 2.2523835 
                 up 
                 MAP3K13 
                 mitogen-activated protein kinase 
               
               
                   
                   
                   
                   
                 kinase kinase 13 
               
               
                 244852_at 
                 2.2514307 
                 up 
                 DSEL 
                 dermatan sulfate epimerase-like 
               
               
                 203980_at 
                 2.2506835 
                 up 
                 FABP4 
                 fatty acid binding protein 4, adipocyte 
               
               
                 212585_at 
                 2.2501442 
                 up 
                 OSBPL8 
                 oxysterol binding protein-like 8 
               
               
                 210845_s_at 
                 2.249447 
                 up 
                 PLAUR 
                 plasminogen activator, urokinase 
               
               
                   
                   
                   
                   
                 receptor 
               
               
                 223463_at 
                 2.2488134 
                 up 
                 RAB23 
                 RAB23, member RAS oncogene 
               
               
                   
                   
                   
                   
                 family 
               
               
                 209204_at 
                 2.2469199 
                 up 
                 LMO4 
                 LIM domain only 4 
               
               
                 227445_at 
                 2.2429285 
                 up 
                 ZNF689 
                 zinc finger protein 689 
               
               
                 223222_at 
                 2.2426856 
                 up 
                 SLC25A19 
                 solute carrier family 25 (mitochondrial 
               
               
                   
                   
                   
                   
                 thiamine pyrophosphate carrier), 
               
               
                   
                   
                   
                   
                 member 19 
               
               
                 209277_at 
                 2.2425933 
                 up 
                 TFPI2 
                 tissue factor pathway inhibitor 2 
               
               
                 205138_s_at 
                 2.241066 
                 up 
                 UST 
                 uronyl-2-sulfotransferase 
               
               
                 219390_at 
                 2.240858 
                 up 
                 FKBP14 
                 FK506 binding protein 14, 22 kDa 
               
               
                 223315_at 
                 2.240703 
                 up 
                 NTN4 
                 netrin 4 
               
               
                 213309_at 
                 2.2406566 
                 up 
                 PLCL2 
                 phospholipase C-like 2 
               
               
                 218541_s_at 
                 2.2391245 
                 up 
                 C8orf4 
                 chromosome 8 open reading frame 4 
               
               
                 210510_s_at 
                 2.2383678 
                 up 
                 NRP1 
                 neuropilin 1 
               
               
                 212915_at 
                 2.2363226 
                 up 
                 PDZRN3 
                 PDZ domain containing ring finger 3 
               
               
                 226890_at 
                 2.2358947 
                 up 
                 WDR35 
                 WD repeat domain 35 
               
               
                 224523_s_at 
                 2.2345538 
                 up 
                 C3orf26 
                 chromosome 3 open reading frame 26 
               
               
                 213029_at 
                 2.2345178 
                 up 
                 NFIB 
                 nuclear factor I/B 
               
               
                 204597_x_at 
                 2.2341132 
                 up 
                 STC1 
                 stanniocalcin 1 
               
               
                 204595_s_at 
                 2.2336535 
                 up 
                 STC1 
                 stanniocalcin 1 
               
               
                 210875_s_at 
                 2.233045 
                 up 
                 ZEB1 
                 zinc finger E-box binding homeobox 1 
               
               
                 210257_x_at 
                 2.231 
                 up 
                 CUL4B 
                 cullin 4B 
               
               
                 230123_at 
                 2.2295592 
                 up 
                 NECAP2 
                 NECAP endocytosis associated 2 
               
               
                 229588_at 
                 2.229439 
                 up 
                 DNAJC10 
                 DnaJ (Hsp40) homolog, subfamily C, 
               
               
                   
                   
                   
                   
                 member 10 
               
               
                 220092_s_at 
                 2.2293727 
                 up 
                 ANTXR1 
                 anthrax toxin receptor 1 
               
               
                 213417_at 
                 2.228594 
                 up 
                 TBX2 
                 T-box 2 
               
               
                 228986_at 
                 2.2255878 
                 up 
                 OSBPL8 
                 oxysterol binding protein-like 8 
               
               
                 201531_at 
                 2.2251139 
                 up 
                 ZFP36 
                 zinc finger protein 36, C3H type, 
               
               
                   
                   
                   
                   
                 homolog (mouse) 
               
               
                 210896_s_at 
                 2.224665 
                 up 
                 ASPH 
                 aspartate beta-hydroxylase 
               
               
                 222619_at 
                 2.2228825 
                 up 
                 ZNF281 
                 zinc finger protein 281 
               
               
                 220254_at 
                 2.2226748 
                 up 
                 LRP12 
                 low density lipoprotein-related protein 
               
               
                   
                   
                   
                   
                 12 
               
               
                 219910_at 
                 2.220998 
                 up 
                 FICD 
                 FIC domain containing 
               
               
                 227351_at 
                 2.2207675 
                 up 
                 C16orf52 
                 chromosome 16 open reading frame 52 
               
               
                 218401_s_at 
                 2.2176473 
                 up 
                 ZNF281 
                 zinc finger protein 281 
               
               
                 201289_at 
                 2.2144566 
                 up 
                 CYR61 
                 cysteine-rich, angiogenic inducer, 61 
               
               
                 202543_s_at 
                 2.2127845 
                 up 
                 GMFB 
                 glia maturation factor, beta 
               
               
                 213113_s_at 
                 2.211486 
                 up 
                 SLC43A3 
                 solute carrier family 43, member 3 
               
               
                 226337_at 
                 2.2105165 
                 up 
                 SCYL1BP1 
                 SCY1-like 1 binding protein 1 
               
               
                 221958_s_at 
                 2.209569 
                 up 
                 GPR177 
                 G protein-coupled receptor 177 
               
               
                 219985_at 
                 2.2090566 
                 up 
                 HS3ST3A1 
                 heparan sulfate (glucosamine) 3-O- 
               
               
                   
                   
                   
                   
                 sulfotransferase 3A1 
               
               
                 223866_at 
                 2.2079794 
                 up 
                 ARMC2 
                 armadillo repeat containing 2 
               
               
                 221978_at 
                 2.207626 
                 up 
                 HLA-F 
                 major histocompatibility complex, 
               
               
                   
                   
                   
                   
                 class I, F 
               
               
                 240728_at 
                 2.20726 
                 up 
                 PLCB4 
                 Phospholipase C beta 4 (PLCB4) 
               
               
                 213338_at 
                 2.2054002 
                 up 
                 TMEM158 
                 transmembrane protein 158 
               
               
                 204151_x_at 
                 2.205384 
                 up 
                 AKR1C1 
                 aldo-keto reductase family 1, member 
               
               
                   
                   
                   
                   
                 C1 (dihydrodiol dehydrogenase 1; 20- 
               
               
                   
                   
                   
                   
                 alpha (3-alpha)-hydroxysteroid 
               
               
                   
                   
                   
                   
                 dehydrogenase) 
               
               
                 1554414_a_at 
                 2.2053685 
                 up 
                 OSGIN2 
                 oxidative stress induced growth 
               
               
                   
                   
                   
                   
                 inhibitor family member 2 
               
               
                 209708_at 
                 2.2048678 
                 up 
                 MOXD1 
                 monooxygenase, DBH-like 1 
               
               
                 229868_s_at 
                 2.2048671 
                 up 
                 GDF15 
                 Macrophage inhibitory cytokine-1 
               
               
                   
                   
                   
                   
                 (MIC-1) 
               
               
                 230031_at 
                 2.2040954 
                 up 
                 HSPA5 
                 heat shock 70 kDa protein 5 (glucose- 
               
               
                   
                   
                   
                   
                 regulated protein, 78 kDa) 
               
               
                 203857_s_at 
                 2.203801 
                 up 
                 PDIA5 
                 protein disulfide isomerase family A, 
               
               
                   
                   
                   
                   
                 member 5 
               
               
                 239286_at 
                 2.2035995 
                 up 
                 CDH11 
                 cadherin 11, type 2, OB-cadherin 
               
               
                   
                   
                   
                   
                 (osteoblast) 
               
               
                 225174_at 
                 2.2034101 
                 up 
                 DNAJC10 
                 DnaJ (Hsp40) homolog, subfamily C, 
               
               
                   
                   
                   
                   
                 member 10 
               
               
                 235706_at 
                 2.202396 
                 up 
                 CPM 
                 carboxypeptidase M 
               
               
                 205495_s_at 
                 2.2022398 
                 up 
                 GNLY 
                 granulysin 
               
               
                 235550_at 
                 2.2019966 
                 up 
                 MAP9 
                 microtubule-associated protein 9 
               
               
                 210275_s_at 
                 2.2013817 
                 up 
                 ZFAND5 
                 zinc finger, AN1-type domain 5 
               
               
                 216218_s_at 
                 2.2008579 
                 up 
                 PLCL2 
                 phospholipase C-like 2 
               
               
                 202888_s_at 
                 2.2007616 
                 up 
                 ANPEP 
                 alanyl (membrane) aminopeptidase 
               
               
                 210191_s_at 
                 2.199756 
                 up 
                 PHTF1 
                 putative homeodomain transcription 
               
               
                   
                   
                   
                   
                 factor 1 
               
               
                 209781_s_at 
                 2.199483 
                 up 
                 KHDRBS3 
                 KH domain containing, RNA binding, 
               
               
                   
                   
                   
                   
                 signal transduction associated 3 
               
               
                 1554036_at 
                 2.1965137 
                 up 
                 ZBTB24 
                 zinc finger and BTB domain 
               
               
                   
                   
                   
                   
                 containing 24 
               
               
                 238669_at 
                 2.1943119 
                 up 
                 PTGS1 
                 prostaglandin-endoperoxide synthase 1 
               
               
                   
                   
                   
                   
                 (prostaglandin G/H synthase and 
               
               
                   
                   
                   
                   
                 cyclooxygenase) 
               
               
                 213036_x_at 
                 2.191737 
                 up 
                 ATP2A3 
                 ATPase, Ca++ transporting, ubiquitous 
               
               
                 227220_at 
                 2.1902707 
                 up 
                 NFXL1 
                 nuclear transcription factor, X-box 
               
               
                   
                   
                   
                   
                 binding-like 1 
               
               
                 236129_at 
                 2.1839883 
                 up 
                 GALNT5 
                 CDNA FLJ75131 complete cds, highly 
               
               
                   
                   
                   
                   
                 similar to  Homo sapiens  UDP-N- 
               
               
                   
                   
                   
                   
                 acetyl-alpha-D- 
               
               
                   
                   
                   
                   
                 galactosamine:polypeptide N- 
               
               
                   
                   
                   
                   
                 acetylgalactosaminyltransferase 5 
               
               
                   
                   
                   
                   
                 (GalNAc-T5) (GALNT5), mRNA 
               
               
                 1555724_s_at 
                 2.1835961 
                 up 
                 TAGLN 
                 transgelin 
               
               
                 208510_s_at 
                 2.1819134 
                 up 
                 PPARG 
                 peroxisome proliferator-activated 
               
               
                   
                   
                   
                   
                 receptor gamma 
               
               
                 229271_x_at 
                 2.1817298 
                 up 
                 COL11A1 
                 collagen, type XI, alpha 1 
               
               
                 219631_at 
                 2.1808488 
                 up 
                 LRP12 
                 low density lipoprotein-related protein 
               
               
                   
                   
                   
                   
                 12 
               
               
                 218193_s_at 
                 2.1798851 
                 up 
                 GOLT1B 
                 golgi transport 1 homolog B ( S. cerevisiae ) 
               
               
                 227660_at 
                 2.1793392 
                 up 
                 ANTXR1 
                 anthrax toxin receptor 1 
               
               
                 1552309_a_at 
                 2.176896 
                 up 
                 NEXN 
                 nexilin (F actin binding protein) 
               
               
                 214061_at 
                 2.1762218 
                 up 
                 WDR67 
                 WD repeat domain 67 
               
               
                 227294_at 
                 2.1758094 
                 up 
                 ZNF689 
                 zinc finger protein 689 
               
               
                 223296_at 
                 2.175538 
                 up 
                 SLC25A33 
                 solute carrier family 25, member 33 
               
               
                 203425_s_at 
                 2.1755157 
                 up 
                 IGFBP5 
                 insulin-like growth factor binding 
               
               
                   
                   
                   
                   
                 protein 5 
               
               
                 226001_at 
                 2.1747112 
                 up 
                 KLHL5 
                 kelch-like 5 ( Drosophila ) 
               
               
                 206445_s_at 
                 2.1745844 
                 up 
                 PRMT1 
                 protein arginine methyltransferase 1 
               
               
                 213988_s_at 
                 2.1742477 
                 up 
                 SAT1 
                 spermidine/spermine N1- 
               
               
                   
                   
                   
                   
                 acetyltransferase 1 
               
               
                 214657_s_at 
                 2.1736887 
                 up 
                 NCRNA00084 
                 non-protein coding RNA 84 
               
               
                 210350_x_at 
                 2.1736152 
                 up 
                 ING1 
                 inhibitor of growth family, member 1 
               
               
                 204556_s_at 
                 2.1734612 
                 up 
                 DZIP1 
                 DAZ interacting protein 1 
               
               
                 207345_at 
                 2.170217 
                 up 
                 FST 
                 follistatin 
               
               
                 220301_at 
                 2.1696754 
                 up 
                 CCDC102B 
                 coiled-coil domain containing 102B 
               
               
                 203574_at 
                 2.169319 
                 up 
                 NFIL3 
                 nuclear factor, interleukin 3 regulated 
               
               
                 215058_at 
                 2.1687279 
                 up 
                 DENND5B 
                 DENN/MADD domain containing 5B 
               
               
                 238497_at 
                 2.1683004 
                 up 
                 TMEM136 
                 transmembrane protein 136 
               
               
                 239468_at 
                 2.167167 
                 up 
                 MKX 
                 mohawk homeobox 
               
               
                 1554474_a_at 
                 2.1654644 
                 up 
                 MOXD1 
                 monooxygenase, DBH-like 1 
               
               
                 205991_s_at 
                 2.1652021 
                 up 
                 PRRX1 
                 paired related homeobox 1 
               
               
                 219500_at 
                 2.1651778 
                 up 
                 CLCF1 
                 cardiotrophin-like cytokine factor 1 
               
               
                 207829_s_at 
                 2.1641598 
                 up 
                 BNIP1 
                 BCL2/adenovirus E1B 19 kDa 
               
               
                   
                   
                   
                   
                 interacting protein 1 
               
               
                 37226_at 
                 2.1634657 
                 up 
                 BNIP1 
                 BCL2/adenovirus E1B 19 kDa 
               
               
                   
                   
                   
                   
                 interacting protein 1 
               
               
                 209850_s_at 
                 2.160621 
                 up 
                 CDC42EP2 
                 CDC42 effector protein (Rho GTPase 
               
               
                   
                   
                   
                   
                 binding) 2 
               
               
                 217741_s_at 
                 2.1604116 
                 up 
                 ZFAND5 
                 zinc finger, AN1-type domain 5 
               
               
                 1554140_at 
                 2.1590114 
                 up 
                 WDR78 
                 WD repeat domain 78 
               
               
                 205110_s_at 
                 2.1575923 
                 up 
                 FGF13 
                 fibroblast growth factor 13 
               
               
                 63825_at 
                 2.157092 
                 up 
                 ABHD2 
                 abhydrolase domain containing 2 
               
               
                 228702_at 
                 2.1557388 
                 up 
                 FLJ43663 
                 hypothetical LOC378805 
               
               
                 226800_at 
                 2.1555407 
                 up 
                 EFCAB7 
                 EF-hand calcium binding domain 7 
               
               
                 202952_s_at 
                 2.155327 
                 up 
                 ADAM12 
                 ADAM metallopeptidase domain 12 
               
               
                 217739_s_at 
                 2.155086 
                 up 
                 NAMPT 
                 nicotinamide 
               
               
                   
                   
                   
                   
                 phosphoribosyltransferase 
               
               
                 225185_at 
                 2.1548986 
                 up 
                 MRAS 
                 muscle RAS oncogene homolog 
               
               
                 214211_at 
                 2.1543927 
                 up 
                 FTH1 
                 ferritin, heavy polypeptide 1 
               
               
                 235311_at 
                 2.15348 
                 up 
                 FKBP14 
                 FK506 binding protein 14, 22 kDa, 
               
               
                   
                   
                   
                   
                 mRNA (cDNA clone MGC: 12218 
               
               
                   
                   
                   
                   
                 IMAGE: 4042173) 
               
               
                 225871_at 
                 2.153166 
                 up 
                 STEAP2 
                 six transmembrane epithelial antigen of 
               
               
                   
                   
                   
                   
                 the prostate 2 
               
               
                 1561042_at 
                 2.1507823 
                 up 
                 ITGB1 
                 integrin, beta 1 (fibronectin receptor, 
               
               
                   
                   
                   
                   
                 beta polypeptide, antigen CD29 
               
               
                   
                   
                   
                   
                 includes MDF2, MSK12) 
               
               
                 204790_at 
                 2.1506758 
                 up 
                 SMAD7 
                 SMAD family member 7 
               
               
                 203518_at 
                 2.1503856 
                 up 
                 LYST 
                 lysosomal trafficking regulator 
               
               
                 208415_x_at 
                 2.1496897 
                 up 
                 ING1 
                 inhibitor of growth family, member 1 
               
               
                 230291_s_at 
                 2.1495125 
                 up 
                 NFIB 
                 HMGIC/NFIB fusion protein 
               
               
                   
                   
                   
                   
                 (HMGIC/NFIB) 
               
               
                 213032_at 
                 2.146494 
                 up 
                 NFIB 
                 nuclear factor I/B 
               
               
                 214913_at 
                 2.1450849 
                 up 
                 ADAMTS3 
                 ADAM metallopeptidase with 
               
               
                   
                   
                   
                   
                 thrombospondin type 1 motif, 3 
               
               
                 209436_at 
                 2.1450522 
                 up 
                 SPON1 
                 spondin 1, extracellular matrix protein 
               
               
                 210355_at 
                 2.1439502 
                 up 
                 PTHLH 
                 parathyroid hormone-like hormone 
               
               
                 225436_at 
                 2.1422665 
                 up 
                 FAM108C1 
                 family with sequence similarity 108, 
               
               
                   
                   
                   
                   
                 member C1 
               
               
                 1554602_at 
                 2.1414428 
                 up 
                 RBM8A 
                 RNA binding motif protein 8A 
               
               
                 204420_at 
                 2.1413243 
                 up 
                 FOSL1 
                 FOS-like antigen 1 
               
               
                 204742_s_at 
                 2.1387715 
                 up 
                 PDS5B 
                 PDS5, regulator of cohesion 
               
               
                   
                   
                   
                   
                 maintenance, homolog B ( S. cerevisiae ) 
               
               
                 235182_at 
                 2.138126 
                 up 
                 ISM1 
                 isthmin 1 homolog (zebrafish) 
               
               
                 203740_at 
                 2.1379848 
                 up 
                 MPHOSPH6 
                 M-phase phosphoprotein 6 
               
               
                 215997_s_at 
                 2.1378837 
                 up 
                 CUL4B 
                 cullin 4B 
               
               
                 219558_at 
                 2.1378727 
                 up 
                 ATP13A3 
                 ATPase type 13A3 
               
               
                 223758_s_at 
                 2.137832 
                 up 
                 GTF2H2 
                 general transcription factor IIH, 
               
               
                   
                   
                   
                   
                 polypeptide 2, 44 kDa 
               
               
                 241986_at 
                 2.1363626 
                 up 
                 BMPER 
                 BMP binding endothelial regulator 
               
               
                 232267_at 
                 2.135431 
                 up 
                 GPR133 
                 G protein-coupled receptor 133 
               
               
                 210841_s_at 
                 2.132714 
                 up 
                 NRP2 
                 neuropilin 2 
               
               
                 229623_at 
                 2.1318607 
                 up 
                 FLJ12993 
                 Hypothetical LOC441027 (FLJ12993), 
               
               
                   
                   
                   
                   
                 mRNA 
               
               
                 224461_s_at 
                 2.13164 
                 up 
                 AIFM2 
                 apoptosis-inducing factor, 
               
               
                   
                   
                   
                   
                 mitochondrion-associated, 2 
               
               
                 219774_at 
                 2.1300507 
                 up 
                 CCDC93 
                 coiled-coil domain containing 93 
               
               
                 229306_at 
                 2.129455 
                 up 
                 FAM148B 
                 Family with sequence similarity 148, 
               
               
                   
                   
                   
                   
                 member B (FAM148B), mRNA 
               
               
                 226142_at 
                 2.1290789 
                 up 
                 GLIPR1 
                 GLI pathogenesis-related 1 
               
               
                 210424_s_at 
                 2.1265538 
                 up 
                 GOLGA8A 
                 golgi autoantigen, golgin subfamily a, 
               
               
                   
                   
                   
                 /// 
                 8A /// golgi autoantigen, golgin 
               
               
                   
                   
                   
                 GOLGA8B 
                 subfamily a, 8B 
               
               
                 232004_at 
                 2.1262782 
                 up 
                 HNRNPR 
                 heterogeneous nuclear 
               
               
                   
                   
                   
                   
                 ribonucleoprotein R 
               
               
                 228950_s_at 
                 2.1261652 
                 up 
                 GPR177 
                 G protein-coupled receptor 177 
               
               
                 239415_at 
                 2.1261606 
                 up 
                 MAP9 
                 microtubule-associated protein 9 
               
               
                 213093_at 
                 2.125206 
                 up 
                 PRKCA 
                 protein kinase C, alpha 
               
               
                 213033_s_at 
                 2.1251779 
                 up 
                 NFIB 
                 nuclear factor I/B 
               
               
                 218574_s_at 
                 2.1227338 
                 up 
                 LMCD1 
                 LIM and cysteine-rich domains 1 
               
               
                 201467_s_at 
                 2.1219635 
                 up 
                 NQO1 
                 NAD(P)H dehydrogenase, quinone 1 
               
               
                 224978_s_at 
                 2.1217666 
                 up 
                 USP36 
                 ubiquitin specific peptidase 36 
               
               
                 232311_at 
                 2.1214871 
                 up 
                 B2M 
                 Beta 2-mu = beta 2-microglobulin 
               
               
                   
                   
                   
                   
                 [human, SK-MEL-33 cells, mRNA 
               
               
                   
                   
                   
                   
                 Mutant, 433 nt] 
               
               
                 211981_at 
                 2.121121 
                 up 
                 COL4A1 
                 collagen, type IV, alpha 1 
               
               
                 219471_at 
                 2.1198602 
                 up 
                 C13orf18 /// 
                 chromosome 13 open reading frame 18 
               
               
                   
                   
                   
                 LOC728970 
                 /// hypothetical LOC728970 
               
               
                 214014_at 
                 2.119122 
                 up 
                 CDC42EP2 
                 CDC42 effector protein (Rho GTPase 
               
               
                   
                   
                   
                   
                 binding) 2 
               
               
                 235019_at 
                 2.1169195 
                 up 
                 CPM 
                 carboxypeptidase M 
               
               
                 218810_at 
                 2.1168468 
                 up 
                 ZC3H12A 
                 zinc finger CCCH-type containing 12A 
               
               
                 210519_s_at 
                 2.116195 
                 up 
                 NQO1 
                 NAD(P)H dehydrogenase, quinone 1 
               
               
                 219790_s_at 
                 2.1150982 
                 up 
                 NPR3 
                 natriuretic peptide receptor 
               
               
                   
                   
                   
                   
                 C/guanylate cyclase C (atrionatriuretic 
               
               
                   
                   
                   
                   
                 peptide receptor C) 
               
               
                 215012_at 
                 2.1141691 
                 up 
                 ZNF451 
                 zinc finger protein 451 
               
               
                 203853_s_at 
                 2.114138 
                 up 
                 GAB2 
                 GRB2-associated binding protein 2 
               
               
                 229553_at 
                 2.1131918 
                 up 
                 PGM2L1 
                 phosphoglucomutase 2-like 1 
               
               
                 203066_at 
                 2.1125245 
                 up 
                 GALNAC4S- 
                 B cell RAG associated protein 
               
               
                   
                   
                   
                 6ST 
               
               
                 221881_s_at 
                 2.1089115 
                 up 
                 CLIC4 
                 chloride intracellular channel 4 
               
               
                 229414_at 
                 2.1082094 
                 up 
                 PITPNC1 
                 phosphatidylinositol transfer protein, 
               
               
                   
                   
                   
                   
                 cytoplasmic 1 
               
               
                 228082_at 
                 2.1080198 
                 up 
                 ASAM 
                 adipocyte-specific adhesion molecule 
               
               
                 225212_at 
                 2.1078928 
                 up 
                 SLC25A25 
                 solute carrier family 25 (mitochondrial 
               
               
                   
                   
                   
                   
                 carrier; phosphate carrier), member 25 
               
               
                 204115_at 
                 2.1078105 
                 up 
                 GNG11 
                 guanine nucleotide binding protein (G 
               
               
                   
                   
                   
                   
                 protein), gamma 11 
               
               
                 229194_at 
                 2.1072176 
                 up 
                 PCGF5 
                 polycomb group ring finger 5 
               
               
                 219283_at 
                 2.107142 
                 up 
                 C1GALT1C1 
                 C1GALT1-specific chaperone 1 
               
               
                 215785_s_at 
                 2.1066854 
                 up 
                 CYFIP2 
                 cytoplasmic FMR1 interacting protein 2 
               
               
                 217202_s_at 
                 2.1064858 
                 up 
                 GLUL 
                 glutamate-ammonia ligase (glutamine 
               
               
                   
                   
                   
                   
                 synthetase) 
               
               
                 228949_at 
                 2.1053102 
                 up 
                 GPR177 
                 G protein-coupled receptor 177 
               
               
                 226136_at 
                 2.10407 
                 up 
                 GLIPR1 
                 GLI pathogenesis-related 1 
               
               
                 225590_at 
                 2.1038868 
                 up 
                 SH3RF1 
                 SH3 domain containing ring finger 1 
               
               
                 226160_at 
                 2.1030507 
                 up 
                 H6PD 
                 hexose-6-phosphate dehydrogenase 
               
               
                   
                   
                   
                   
                 (glucose 1-dehydrogenase) 
               
               
                 236154_at 
                 2.1026752 
                 up 
                 QKI 
                 CDNA FLJ39382 fis, clone 
               
               
                   
                   
                   
                   
                 PERIC2000473 
               
               
                 225034_at 
                 2.099384 
                 up 
                 ST3GAL1 
                 ST3 beta-galactoside alpha-2,3- 
               
               
                   
                   
                   
                   
                 sialyltransferase 1 
               
               
                 202724_s_at 
                 2.0982356 
                 up 
                 FOXO1 
                 forkhead box O1 
               
               
                 1559477_s_at 
                 2.0980742 
                 up 
                 MEIS1 
                 Meis homeobox 1 
               
               
                 226731_at 
                 2.0977373 
                 up 
                 PELO 
                 Pelota major mRNA, complete cds; 
               
               
                   
                   
                   
                   
                 alternatively spliced 
               
               
                 220253_s_at 
                 2.0964284 
                 up 
                 LRP12 
                 low density lipoprotein-related protein 
               
               
                   
                   
                   
                   
                 12 
               
               
                 1555270_a_at 
                 2.0956323 
                 up 
                 WFS1 
                 Wolfram syndrome 1 (wolframin) 
               
               
                 219054_at 
                 2.0956144 
                 up 
                 C5orf23 
                 chromosome 5 open reading frame 23 
               
               
                 1553962_s_at 
                 2.0940528 
                 up 
                 RHOB 
                 ras homolog gene family, member B 
               
               
                 201468_s_at 
                 2.0929265 
                 up 
                 NQO1 
                 NAD(P)H dehydrogenase, quinone 1 
               
               
                 211725_s_at 
                 2.0922117 
                 up 
                 BID 
                 BH3 interacting domain death agonist 
               
               
                 210665_at 
                 2.091109 
                 up 
                 TFPI 
                 tissue factor pathway inhibitor 
               
               
                   
                   
                   
                   
                 (lipoprotein-associated coagulation 
               
               
                   
                   
                   
                   
                 inhibitor) 
               
               
                 243797_at 
                 2.089624 
                 up 
                 STK17B 
                 serine/threonine kinase 17b 
               
               
                 204456_s_at 
                 2.0887516 
                 up 
                 GAS1 
                 growth arrest-specific 1 
               
               
                 243631_at 
                 2.0873725 
                 up 
                 LOC727815 
                 hypothetical LOC727815 
               
               
                 204396_s_at 
                 2.0871058 
                 up 
                 GRK5 
                 G protein-coupled receptor kinase 5 
               
               
                 213994_s_at 
                 2.0860326 
                 up 
                 SPON1 
                 spondin 1, extracellular matrix protein 
               
               
                 213790_at 
                 2.0849094 
                 up 
                 ADAM12 
                 ADAM metallopeptidase domain 12 
               
               
                 244752_at 
                 2.0830863 
                 up 
                 ZNF438 
                 zinc finger protein 438 
               
               
                 212554_at 
                 2.0824976 
                 up 
                 CAP2 
                 CAP, adenylate cyclase-associated 
               
               
                   
                   
                   
                   
                 protein, 2 (yeast) 
               
               
                 239108_at 
                 2.081294 
                 up 
                 FAR2 
                 Fatty acyl CoA reductase 2, mRNA 
               
               
                   
                   
                   
                   
                 (cDNA clone MGC: 22328 
               
               
                   
                   
                   
                   
                 IMAGE: 4732586) 
               
               
                 219284_at 
                 2.0798855 
                 up 
                 HSPBAP1 
                 HSPB (heat shock 27 kDa) associated 
               
               
                   
                   
                   
                   
                 protein 1 
               
               
                 221586_s_at 
                 2.0788653 
                 up 
                 E2F5 
                 E2F transcription factor 5, p130- 
               
               
                   
                   
                   
                   
                 binding 
               
               
                 218665_at 
                 2.0779874 
                 up 
                 FZD4 
                 frizzled homolog 4 ( Drosophila ) 
               
               
                 240395_at 
                 2.077514 
                 up 
                 LOC100128727 
                 hypothetical LOC100128727 
               
               
                 224583_at 
                 2.0774055 
                 up 
                 COTL1 
                 coactosin-like 1 ( Dictyostelium ) 
               
               
                 203426_s_at 
                 2.0749454 
                 up 
                 IGFBP5 
                 insulin-like growth factor binding 
               
               
                   
                   
                   
                   
                 protein 5 
               
               
                 238893_at 
                 2.0748096 
                 up 
                 LOC338758 
                 hypothetical protein LOC338758 
               
               
                 212298_at 
                 2.072682 
                 up 
                 NRP1 
                 neuropilin 1 
               
               
                 210145_at 
                 2.071591 
                 up 
                 PLA2G4A 
                 phospholipase A2, group IVA 
               
               
                   
                   
                   
                   
                 (cytosolic, calcium-dependent) 
               
               
                 229404_at 
                 2.0715733 
                 up 
                 TWIST2 
                 twist homolog 2 ( Drosophila ) 
               
               
                 205659_at 
                 2.0714095 
                 up 
                 HDAC9 
                 histone deacetylase 9 
               
               
                 213173_at 
                 2.071243 
                 up 
                 PCNX 
                 pecanex homolog ( Drosophila ) 
               
               
                 229287_at 
                 2.0710356 
                 up 
                 PCNX 
                 pecanex homolog ( Drosophila ) 
               
               
                 227027_at 
                 2.0672464 
                 up 
                 GFPT1 
                 glutamine-fructose-6-phosphate 
               
               
                   
                   
                   
                   
                 transaminase 1 
               
               
                 205290_s_at 
                 2.064931 
                 up 
                 BMP2 
                 bone morphogenetic protein 2 
               
               
                 227658_s_at 
                 2.0645716 
                 up 
                 PLEKHA3 
                 pleckstrin homology domain 
               
               
                   
                   
                   
                   
                 containing, family A (phosphoinositide 
               
               
                   
                   
                   
                   
                 binding specific) member 3 
               
               
                 209324_s_at 
                 2.0643253 
                 up 
                 RGS16 
                 regulator of G-protein signaling 16 
               
               
                 209699_x_at 
                 2.0639524 
                 up 
                 AKR1C2 
                 aldo-keto reductase family 1, member 
               
               
                   
                   
                   
                   
                 C2 (dihydrodiol dehydrogenase 2; bile 
               
               
                   
                   
                   
                   
                 acid binding protein; 3-alpha 
               
               
                   
                   
                   
                   
                 hydroxysteroid dehydrogenase, type 
               
               
                   
                   
                   
                   
                 III) 
               
               
                 221059_s_at 
                 2.063764 
                 up 
                 COTL1 
                 coactosin-like 1 ( Dictyostelium ) 
               
               
                 219374_s_at 
                 2.0623355 
                 up 
                 ALG9 
                 asparagine-linked glycosylation 9, 
               
               
                   
                   
                   
                   
                 alpha-1,2-mannosyltransferase 
               
               
                   
                   
                   
                   
                 homolog ( S. cerevisiae ) 
               
               
                 229942_at 
                 2.0615158 
                 up 
                 BNC2 
                 basonuclin 2 
               
               
                 212120_at 
                 2.0612128 
                 up 
                 RHOQ 
                 ras homolog gene family, member Q 
               
               
                 242281_at 
                 2.060927 
                 up 
                 GLUL 
                 glutamate-ammonia ligase (glutamine 
               
               
                   
                   
                   
                   
                 synthetase) 
               
               
                 202214_s_at 
                 2.0583868 
                 up 
                 CUL4B 
                 cullin 4B 
               
               
                 201150_s_at 
                 2.0579739 
                 up 
                 TIMP3 
                 TIMP metallopeptidase inhibitor 3 
               
               
                 203927_at 
                 2.0568886 
                 up 
                 NFKBIE 
                 nuclear factor of kappa light 
               
               
                   
                   
                   
                   
                 polypeptide gene enhancer in B-cells 
               
               
                   
                   
                   
                   
                 inhibitor, epsilon 
               
               
                 220980_s_at 
                 2.0566983 
                 up 
                 ADPGK 
                 ADP-dependent glucokinase 
               
               
                 212454_x_at 
                 2.053964 
                 up 
                 HNRPDL 
                 HnRNP JKTBP 
               
               
                 235391_at 
                 2.0537112 
                 up 
                 FAM92A1 
                 family with sequence similarity 92, 
               
               
                   
                   
                   
                   
                 member A1 
               
               
                 202784_s_at 
                 2.053589 
                 up 
                 NNT 
                 nicotinamide nucleotide 
               
               
                   
                   
                   
                   
                 transhydrogenase 
               
               
                 203810_at 
                 2.0534089 
                 up 
                 DNAJB4 
                 DnaJ (Hsp40) homolog, subfamily B, 
               
               
                   
                   
                   
                   
                 member 4 
               
               
                 222731_at 
                 2.0529802 
                 up 
                 ZDHHC2 
                 zinc finger, DHHC-type containing 2 
               
               
                 219682_s_at 
                 2.051939 
                 up 
                 TBX3 
                 T-box 3 
               
               
                 200755_s_at 
                 2.0517964 
                 up 
                 CALU 
                 calumenin 
               
               
                 210198_s_at 
                 2.051592 
                 up 
                 PLP1 
                 proteolipid protein 1 
               
               
                 203294_s_at 
                 2.0499084 
                 up 
                 LMAN1 
                 lectin, mannose-binding, 1 
               
               
                 210243_s_at 
                 2.0492911 
                 up 
                 B4GALT3 
                 UDP-Gal:betaGlcNAc beta 1,4- 
               
               
                   
                   
                   
                   
                 galactosyltransferase, polypeptide 3 
               
               
                 201772_at 
                 2.0489492 
                 up 
                 AZIN1 
                 antizyme inhibitor 1 
               
               
                 218513_at 
                 2.046744 
                 up 
                 C4orf43 
                 chromosome 4 open reading frame 43 
               
               
                 212110_at 
                 2.0458658 
                 up 
                 SLC39A14 
                 solute carrier family 39 (zinc 
               
               
                   
                   
                   
                   
                 transporter), member 14 
               
               
                 244246_at 
                 2.0455189 
                 up 
                 MIPOL1 
                 mirror-image polydactyly 1 
               
               
                 235359_at 
                 2.0454898 
                 up 
                 LRRC33 
                 leucine rich repeat containing 33 
               
               
                 211952_at 
                 2.0442946 
                 up 
                 IPO5 
                 importin 5 
               
               
                 239261_s_at 
                 2.0437918 
                 up 
                 CORIN 
                 corin, serine peptidase 
               
               
                 40560_at 
                 2.0437784 
                 up 
                 TBX2 
                 T-box 2 
               
               
                 231824_at 
                 2.0437446 
                 up 
                 LARP2 
                 La ribonucleoprotein domain family, 
               
               
                   
                   
                   
                   
                 member 2 
               
               
                 238417_at 
                 2.0436635 
                 up 
                 PGM2L1 
                 phosphoglucomutase 2-like 1 
               
               
                 235061_at 
                 2.0422926 
                 up 
                 PPM1K 
                 protein phosphatase 1K (PP2C domain 
               
               
                   
                   
                   
                   
                 containing) 
               
               
                 214077_x_at 
                 2.0414855 
                 up 
                 MEIS3P1 
                 Meis homeobox 3 pseudogene 1 
               
               
                 212977_at 
                 2.039824 
                 up 
                 CXCR7 
                 chemokine (C—X—C motif) receptor 7 
               
               
                 218178_s_at 
                 2.0365124 
                 up 
                 CHMP1B 
                 chromatin modifying protein 1B 
               
               
                 202581_at 
                 2.0352576 
                 up 
                 HSPA1A /// 
                 heat shock 70 kDa protein 1A /// heat 
               
               
                   
                   
                   
                 HSPA1B 
                 shock 70 kDa protein 1B 
               
               
                 239781_at 
                 2.034794 
                 up 
                 hCG_1815504 
                 hCG1815504 
               
               
                 204845_s_at 
                 2.0343878 
                 up 
                 ENPEP 
                 glutamyl aminopeptidase 
               
               
                   
                   
                   
                   
                 (aminopeptidase A) 
               
               
                 221207_s_at 
                 2.033731 
                 up 
                 NBEA 
                 neurobeachin 
               
               
                 242814_at 
                 2.033107 
                 up 
                 SERPINB9 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 9 
               
               
                 225793_at 
                 2.0320432 
                 up 
                 LIX1L 
                 Lix1 homolog (mouse)-like 
               
               
                 211467_s_at 
                 2.0315952 
                 up 
                 NFIB 
                 nuclear factor I/B 
               
               
                 205499_at 
                 2.0314283 
                 up 
                 SRPX2 
                 sushi-repeat-containing protein, X- 
               
               
                   
                   
                   
                   
                 linked 2 
               
               
                 202906_s_at 
                 2.0313315 
                 up 
                 NBN 
                 nibrin 
               
               
                 222343_at 
                 2.0312388 
                 up 
                 BCL2L11 
                 BCL2-like 11 (apoptosis facilitator) 
               
               
                 204719_at 
                 2.03084 
                 up 
                 ABCA8 
                 ATP-binding cassette, sub-family A 
               
               
                   
                   
                   
                   
                 (ABC1), member 8 
               
               
                 244128_x_at 
                 2.0301714 
                 up 
                 GLIS1 
                 GLIS family zinc finger 1 
               
               
                 202014_at 
                 2.0300674 
                 up 
                 PPP1R15A 
                 protein phosphatase 1, regulatory 
               
               
                   
                   
                   
                   
                 (inhibitor) subunit 15A 
               
               
                 210001_s_at 
                 2.028387 
                 up 
                 SOCS1 
                 suppressor of cytokine signaling 1 
               
               
                 203184_at 
                 2.0282688 
                 up 
                 FBN2 
                 fibrillin 2 
               
               
                 203835_at 
                 2.0257106 
                 up 
                 LRRC32 
                 leucine rich repeat containing 32 
               
               
                 213435_at 
                 2.0254192 
                 up 
                 SATB2 
                 SATB homeobox 2 
               
               
                 203001_s_at 
                 2.025328 
                 up 
                 STMN2 
                 stathmin-like 2 
               
               
                 216594_x_at 
                 2.0242531 
                 up 
                 AKR1C1 
                 aldo-keto reductase family 1, member 
               
               
                   
                   
                   
                   
                 C1 (dihydrodiol dehydrogenase 1; 20- 
               
               
                   
                   
                   
                   
                 alpha (3-alpha)-hydroxysteroid 
               
               
                   
                   
                   
                   
                 dehydrogenase) 
               
               
                 221062_at 
                 2.0242138 
                 up 
                 HS3ST3B1 
                 heparan sulfate (glucosamine) 3-O- 
               
               
                   
                   
                   
                   
                 sulfotransferase 3B1 
               
               
                 221685_s_at 
                 2.0240426 
                 up 
                 CCDC99 
                 coiled-coil domain containing 99 
               
               
                 210007_s_at 
                 2.0238538 
                 up 
                 GPD2 
                 glycerol-3-phosphate dehydrogenase 2 
               
               
                   
                   
                   
                   
                 (mitochondrial) 
               
               
                 209676_at 
                 2.0226731 
                 up 
                 TFPI 
                 tissue factor pathway inhibitor 
               
               
                   
                   
                   
                   
                 (lipoprotein-associated coagulation 
               
               
                   
                   
                   
                   
                 inhibitor) 
               
               
                 219921_s_at 
                 2.0220945 
                 up 
                 DOCK5 
                 dedicator of cytokinesis 5 
               
               
                 212558_at 
                 2.0209737 
                 up 
                 SPRY1 
                 sprouty homolog 1, antagonist of FGF 
               
               
                   
                   
                   
                   
                 signaling ( Drosophila ) 
               
               
                 228728_at 
                 2.0184631 
                 up 
                 C7orf58 
                 chromosome 7 open reading frame 58 
               
               
                 1557258_a_at 
                 2.018125 
                 up 
                 BCL10 
                 CDNA FLJ25924 fis, clone CBR05109 
               
               
                 213302_at 
                 2.017492 
                 up 
                 PFAS 
                 phosphoribosylformylglycinamidine 
               
               
                   
                   
                   
                   
                 synthase 
               
               
                 209289_at 
                 2.0158818 
                 up 
                 NFIB 
                 nuclear factor I/B 
               
               
                 230559_x_at 
                 2.0148904 
                 up 
                 FGD4 
                 FYVE, RhoGEF and PH domain 
               
               
                   
                   
                   
                   
                 containing 4 
               
               
                 220093_at 
                 2.0146642 
                 up 
                 ANTXR1 
                 anthrax toxin receptor 1 
               
               
                 214587_at 
                 2.0145714 
                 up 
                 COL8A1 
                 collagen, type VIII, alpha 1 
               
               
                 213359_at 
                 2.013772 
                 up 
                 HNRNPD 
                 HnRNP-C like protein 
               
               
                 200648_s_at 
                 2.0120223 
                 up 
                 GLUL 
                 glutamate-ammonia ligase (glutamine 
               
               
                   
                   
                   
                   
                 synthetase) 
               
               
                 241902_at 
                 2.0113673 
                 up 
                 MKX 
                 mohawk homeobox 
               
               
                 204114_at 
                 2.0113 
                 up 
                 NID2 
                 nidogen 2 (osteonidogen) 
               
               
                 225385_s_at 
                 2.0110688 
                 up 
                 HNRPLL 
                 heterogeneous nuclear 
               
               
                   
                   
                   
                   
                 ribonucleoprotein L-like 
               
               
                 227983_at 
                 2.0109632 
                 up 
                 RILPL2 
                 Rab interacting lysosomal protein-like 2 
               
               
                 203194_s_at 
                 2.0106804 
                 up 
                 NUP98 
                 nucleoporin 98 kDa 
               
               
                 1567107_s_at 
                 2.0090067 
                 up 
                 TPM4 
                 tropomyosin 4 
               
               
                 201941_at 
                 2.0086033 
                 up 
                 CPD 
                 carboxypeptidase D 
               
               
                 202710_at 
                 2.0079546 
                 up 
                 BET1 
                 blocked early in transport 1 homolog 
               
               
                   
                   
                   
                   
                 ( S. cerevisiae ) 
               
               
                 202908_at 
                 2.0073936 
                 up 
                 WFS1 
                 Wolfram syndrome 1 (wolframin) 
               
               
                 202302_s_at 
                 2.0070374 
                 up 
                 RSRC2 
                 arginine/serine-rich coiled-coil 2 
               
               
                 210839_s_at 
                 2.0057895 
                 up 
                 ENPP2 
                 ectonucleotide 
               
               
                   
                   
                   
                   
                 pyrophosphatase/phosphodiesterase 2 
               
               
                 216235_s_at 
                 2.0052087 
                 up 
                 EDNRA 
                 endothelin receptor type A 
               
               
                 218995_s_at 
                 2.0046716 
                 up 
                 EDN1 
                 endothelin 1 
               
               
                 238049_at 
                 2.0043075 
                 up 
                 GRAMD3 
                 GRAM domain containing 3 
               
               
                 1554334_a_at 
                 2.0030234 
                 up 
                 DNAJA4 
                 DnaJ (Hsp40) homolog, subfamily A, 
               
               
                   
                   
                   
                   
                 member 4 
               
               
                 202804_at 
                 2.0030096 
                 up 
                 ABCC1 
                 ATP-binding cassette, sub-family C 
               
               
                   
                   
                   
                   
                 (CFTR/MRP), member 1 
               
               
                 219872_at 
                 2.0028145 
                 up 
                 C4orf18 
                 chromosome 4 open reading frame 18 
               
               
                 237056_at 
                 2.0025263 
                 up 
                 INSC 
                 inscuteable homolog ( Drosophila ) 
               
               
                 209290_s_at 
                 2.0020652 
                 up 
                 NFIB 
                 nuclear factor I/B 
               
               
                 203404_at 
                 2.0020292 
                 up 
                 ARMCX2 
                 armadillo repeat containing, X-linked 2 
               
               
                 200799_at 
                 2.0019038 
                 up 
                 HSPA1A /// 
                 heat shock 70 kDa protein 1A /// heat 
               
               
                   
                   
                   
                 HSPA1B 
                 shock 70 kDa protein 1B 
               
               
                 226025_at 
                 2.0013952 
                 up 
                 ANKRD28 
                 ankyrin repeat domain 28 
               
               
                 207710_at 
                 200.50969 
                 down 
                 LCE2B 
                 late cornified envelope 2B 
               
               
                 221470_s_at 
                 100.54604 
                 down 
                 IL1F7 
                 interleukin 1 family, member 7 (zeta) 
               
               
                 211548_s_at 
                 92.36748 
                 down 
                 HPGD 
                 hydroxyprostaglandin dehydrogenase 
               
               
                   
                   
                   
                   
                 15-(NAD) 
               
               
                 1553081_at 
                 88.25469 
                 down 
                 WFDC12 
                 WAP four-disulfide core domain 12 
               
               
                 203914_x_at 
                 78.77154 
                 down 
                 HPGD 
                 hydroxyprostaglandin dehydrogenase 
               
               
                   
                   
                   
                   
                 15-(NAD) 
               
               
                 231930_at 
                 71.26495 
                 down 
                 ELMOD1 
                 ELMO/CED-12 domain containing 1 
               
               
                 1560531_at 
                 71.235 
                 down 
                 LCE1B 
                 late cornified envelope 1B 
               
               
                 203913_s_at 
                 67.80365 
                 down 
                 HPGD 
                 hydroxyprostaglandin dehydrogenase 
               
               
                   
                   
                   
                   
                 15-(NAD) 
               
               
                 206643_at 
                 55.867226 
                 down 
                 HAL 
                 histidine ammonia-lyase 
               
               
                 211549_s_at 
                 53.149216 
                 down 
                 HPGD 
                 hydroxyprostaglandin dehydrogenase 
               
               
                   
                   
                   
                   
                 15-(NAD) 
               
               
                 240420_at 
                 52.46811 
                 down 
                 AADACL2 
                 arylacetamide deacetylase-like 2 
               
               
                 209309_at 
                 51.06968 
                 down 
                 AZGP1 
                 alpha-2-glycoprotein 1, zinc-binding 
               
               
                 1569410_at 
                 45.91465 
                 down 
                 FLG2 
                 filaggrin family member 2 
               
               
                 239787_at 
                 41.795918 
                 down 
                 KCTD4 
                 potassium channel tetramerisation 
               
               
                   
                   
                   
                   
                 domain containing 4 
               
               
                 216935_at 
                 40.454136 
                 down 
                 C1orf46 
                 chromosome 1 open reading frame 46 
               
               
                 1553602_at 
                 33.973278 
                 down 
                 MUCL1 
                 mucin-like 1 
               
               
                 207720_at 
                 32.353355 
                 down 
                 LOR 
                 loricrin 
               
               
                 220625_s_at 
                 31.788977 
                 down 
                 ELF5 
                 E74-like factor 5 (ets domain 
               
               
                   
                   
                   
                   
                 transcription factor) 
               
               
                 223720_at 
                 25.761408 
                 down 
                 SPINK7 
                 serine peptidase inhibitor, Kazal type 7 
               
               
                   
                   
                   
                   
                 (putative) 
               
               
                 241412_at 
                 25.479097 
                 down 
                 BTC 
                 betacellulin 
               
               
                 224555_x_at 
                 21.945213 
                 down 
                 IL1F7 
                 interleukin 1 family, member 7 (zeta) 
               
               
                 235514_at 
                 21.287827 
                 down 
                 ASPRV1 
                 aspartic peptidase, retroviral-like 1 
               
               
                 237974_at 
                 21.200142 
                 down 
                 ABHD12B 
                 abhydrolase domain containing 12B 
               
               
                 1552532_a_at 
                 20.645466 
                 down 
                 ATP6V1C2 
                 ATPase, H+ transporting, lysosomal 
               
               
                   
                   
                   
                   
                 42 kDa, V1 subunit C2 
               
               
                 226188_at 
                 20.39768 
                 down 
                 HSPC159 
                 galectin-related protein 
               
               
                 202688_at 
                 20.340603 
                 down 
                 TNFSF10 
                 tumor necrosis factor (ligand) 
               
               
                   
                   
                   
                   
                 superfamily, member 10 
               
               
                 202687_s_at 
                 20.30895 
                 down 
                 TNFSF10 
                 tumor necrosis factor (ligand) 
               
               
                   
                   
                   
                   
                 superfamily, member 10 
               
               
                 205159_at 
                 20.243301 
                 down 
                 CSF2RB 
                 colony stimulating factor 2 receptor, 
               
               
                   
                   
                   
                   
                 beta, low-affinity (granulocyte- 
               
               
                   
                   
                   
                   
                 macrophage) 
               
               
                 1553534_at 
                 20.000898 
                 down 
                 NLRP10 
                 NLR family, pyrin domain containing 
               
               
                   
                   
                   
                   
                 10 
               
               
                 211712_s_at 
                 19.846176 
                 down 
                 ANXA9 
                 annexin A9 
               
               
                 228766_at 
                 19.823524 
                 down 
                 CD36 
                 CD36 molecule (thrombospondin 
               
               
                   
                   
                   
                   
                 receptor) 
               
               
                 219476_at 
                 19.65667 
                 down 
                 C1orf116 
                 chromosome 1 open reading frame 116 
               
               
                 206295_at 
                 19.309084 
                 down 
                 IL18 
                 interleukin 18 (interferon-gamma- 
               
               
                   
                   
                   
                   
                 inducing factor) 
               
               
                 220635_at 
                 19.078548 
                 down 
                 PSORS1C2 
                 psoriasis susceptibility 1 candidate 2 
               
               
                 223816_at 
                 18.854237 
                 down 
                 SLC46A2 
                 solute carrier family 46, member 2 
               
               
                 240512_x_at 
                 18.449383 
                 down 
                 KCTD4 
                 potassium channel tetramerisation 
               
               
                   
                   
                   
                   
                 domain containing 4 
               
               
                 1552544_at 
                 18.410263 
                 down 
                 SERPINA12 
                 serpin peptidase inhibitor, clade A 
               
               
                   
                   
                   
                   
                 (alpha-1 antiproteinase, antitrypsin), 
               
               
                   
                   
                   
                   
                 member 12 
               
               
                 207908_at 
                 18.13667 
                 down 
                 KRT2 
                 keratin 2 
               
               
                 202454_s_at 
                 17.877632 
                 down 
                 ERBB3 
                 v-erb-b2 erythroblastic leukemia viral 
               
               
                   
                   
                   
                   
                 oncogene homolog 3 (avian) 
               
               
                 233488_at 
                 17.474066 
                 down 
                 RNASE7 
                 ribonuclease, RNase A family, 7 
               
               
                 225667_s_at 
                 17.434992 
                 down 
                 FAM84A 
                 family with sequence similarity 84, 
               
               
                   
                   
                   
                   
                 member A 
               
               
                 234331_s_at 
                 17.273813 
                 down 
                 FAM84A 
                 family with sequence similarity 84, 
               
               
                   
                   
                   
                   
                 member A 
               
               
                 227717_at 
                 17.084187 
                 down 
                 FLJ41603 
                 FLJ41603 protein 
               
               
                 203608_at 
                 17.013868 
                 down 
                 ALDH5A1 
                 aldehyde dehydrogenase 5 family, 
               
               
                   
                   
                   
                   
                 member A1 
               
               
                 227241_at 
                 16.848194 
                 down 
                 MUC15 
                 mucin 15, cell surface associated 
               
               
                 209604_s_at 
                 16.352425 
                 down 
                 GATA3 
                 GATA binding protein 3 
               
               
                 204733_at 
                 16.28207 
                 down 
                 KLK6 
                 kallikrein-related peptidase 6 
               
               
                 1564307_a_at 
                 15.90927 
                 down 
                 A2ML1 
                 alpha-2-macroglobulin-like 1 
               
               
                 209602_s_at 
                 15.703371 
                 down 
                 GATA3 
                 GATA binding protein 3 
               
               
                 1554195_a_at 
                 15.667729 
                 down 
                 C5orf46 
                 chromosome 5 open reading frame 46 
               
               
                 222484_s_at 
                 15.34712 
                 down 
                 CXCL14 
                 chemokine (C—X—C motif) ligand 14 
               
               
                 1554252_a_at 
                 15.340231 
                 down 
                 LASS3 
                 LAG1 homolog, ceramide synthase 3 
               
               
                 203798_s_at 
                 15.19176 
                 down 
                 VSNL1 
                 visinin-like 1 
               
               
                 232170_at 
                 15.098177 
                 down 
                 S100A7A 
                 S100 calcium binding protein A7A 
               
               
                 209493_at 
                 15.042625 
                 down 
                 PDZD2 
                 PDZ domain containing 2 
               
               
                 219795_at 
                 15.010469 
                 down 
                 SLC6A14 
                 solute carrier family 6 (amino acid 
               
               
                   
                   
                   
                   
                 transporter), member 14 
               
               
                 213135_at 
                 14.684513 
                 down 
                 TIAM1 
                 T-cell lymphoma invasion and 
               
               
                   
                   
                   
                   
                 metastasis 1 
               
               
                 237120_at 
                 14.594361 
                 down 
                 KRT77 
                 keratin 77 
               
               
                 226789_at 
                 14.518254 
                 down 
                 LOC647121 
                 embigin homolog (mouse) pseudogene 
               
               
                 1555773_at 
                 13.957752 
                 down 
                 BPIL2 
                 bactericidal/permeability-increasing 
               
               
                   
                   
                   
                   
                 protein-like 2 
               
               
                 205439_at 
                 13.706697 
                 down 
                 GSTT2 
                 glutathione S-transferase theta 2 
               
               
                 219695_at 
                 13.657985 
                 down 
                 SMPD3 
                 sphingomyelin phosphodiesterase 3, 
               
               
                   
                   
                   
                   
                 neutral membrane (neutral 
               
               
                   
                   
                   
                   
                 sphingomyelinase II) 
               
               
                 213933_at 
                 13.583514 
                 down 
                 PTGER3 
                 prostaglandin E receptor 3 (subtype 
               
               
                   
                   
                   
                   
                 EP3) 
               
               
                 214329_x_at 
                 13.48385 
                 down 
                 TNFSF10 
                 tumor necrosis factor (ligand) 
               
               
                   
                   
                   
                   
                 superfamily, member 10 
               
               
                 218454_at 
                 13.372534 
                 down 
                 FLJ22662 
                 hypothetical protein FLJ22662 
               
               
                 213780_at 
                 13.321 
                 down 
                 TCHH 
                 trichohyalin 
               
               
                 231867_at 
                 13.271721 
                 down 
                 ODZ2 
                 odz, odd Oz/ten-m homolog 2 
               
               
                   
                   
                   
                   
                 ( Drosophila ) 
               
               
                 227238_at 
                 13.252493 
                 down 
                 MUC15 
                 mucin 15, cell surface associated 
               
               
                 243386_at 
                 13.026348 
                 down 
                 CASZ1 
                 castor zinc finger 1 
               
               
                 207324_s_at 
                 12.947083 
                 down 
                 DSC1 
                 desmocollin 1 
               
               
                 232165_at 
                 12.401502 
                 down 
                 EPPK1 
                 epiplakin 1 
               
               
                 204393_s_at 
                 12.384473 
                 down 
                 ACPP 
                 acid phosphatase, prostate 
               
               
                 1552797_s_at 
                 12.167754 
                 down 
                 PROM2 
                 prominin 2 
               
               
                 219681_s_at 
                 12.068543 
                 down 
                 RAB11FIP1 
                 RAB11 family interacting protein 1 
               
               
                   
                   
                   
                   
                 (class I) 
               
               
                 219115_s_at 
                 12.066238 
                 down 
                 IL20RA 
                 interleukin 20 receptor, alpha 
               
               
                 203797_at 
                 12.020528 
                 down 
                 VSNL1 
                 visinin-like 1 
               
               
                 1569886_a_at 
                 12.018516 
                 down 
                 GLB1L3 
                 galactosidase, beta 1-like 3 
               
               
                 212531_at 
                 12.014198 
                 down 
                 LCN2 
                 lipocalin 2 
               
               
                 200965_s_at 
                 11.87853 
                 down 
                 ABLIM1 
                 actin binding LIM protein 1 
               
               
                 206177_s_at 
                 11.859509 
                 down 
                 ARG1 
                 arginase, liver 
               
               
                 227449_at 
                 11.784953 
                 down 
                 EPHA4 
                 EPH receptor A4 
               
               
                 205108_s_at 
                 11.751713 
                 down 
                 APOB 
                 apolipoprotein B (including Ag(x) 
               
               
                   
                   
                   
                   
                 antigen) 
               
               
                 210096_at 
                 11.683115 
                 down 
                 CYP4B1 
                 cytochrome P450, family 4, subfamily 
               
               
                   
                   
                   
                   
                 B, polypeptide 1 
               
               
                 217014_s_at 
                 11.667914 
                 down 
                 AZGP1 /// 
                 alpha-2-glycoprotein 1, zinc-binding /// 
               
               
                   
                   
                   
                 AZGP1P1 
                 alpha-2-glycoprotein 1, zinc-binding 
               
               
                   
                   
                   
                   
                 pseudogene 1 
               
               
                 1564333_a_at 
                 11.665463 
                 down 
                 PSAPL1 
                 prosaposin-like 1 
               
               
                 222891_s_at 
                 11.499077 
                 down 
                 BCL11A 
                 B-cell CLL/lymphoma 11A (zinc 
               
               
                   
                   
                   
                   
                 finger protein) 
               
               
                 224262_at 
                 11.446743 
                 down 
                 IL1F10 
                 interleukin 1 family, member 10 (theta) 
               
               
                 238778_at 
                 11.35283 
                 down 
                 MPP7 
                 membrane protein, palmitoylated 7 
               
               
                   
                   
                   
                   
                 (MAGUK p55 subfamily member 7) 
               
               
                 219895_at 
                 11.33746 
                 down 
                 FAM70A 
                 family with sequence similarity 70, 
               
               
                   
                   
                   
                   
                 member A 
               
               
                 210020_x_at 
                 11.268426 
                 down 
                 CALML3 
                 calmodulin-like 3 
               
               
                 210085_s_at 
                 11.268161 
                 down 
                 ANXA9 
                 annexin A9 
               
               
                 207367_at 
                 11.168736 
                 down 
                 ATP12A 
                 ATPase, H+/K+ transporting, 
               
               
                   
                   
                   
                   
                 nongastric, alpha polypeptide 
               
               
                 207008_at 
                 11.107841 
                 down 
                 IL8RB 
                 interleukin 8 receptor, beta 
               
               
                 206193_s_at 
                 11.105947 
                 down 
                 CDSN 
                 corneodesmosin 
               
               
                 218963_s_at 
                 10.944303 
                 down 
                 KRT23 
                 keratin 23 (histone deacetylase 
               
               
                   
                   
                   
                   
                 inducible) 
               
               
                 206192_at 
                 10.920915 
                 down 
                 CDSN 
                 corneodesmosin 
               
               
                 207254_at 
                 10.88806 
                 down 
                 SLC15A1 
                 solute carrier family 15 (oligopeptide 
               
               
                   
                   
                   
                   
                 transporter), member 1 
               
               
                 220724_at 
                 10.756084 
                 down 
                 FLJ21511 
                 hypothetical protein FLJ21511 
               
               
                 219858_s_at 
                 10.733388 
                 down 
                 MFSD6 
                 major facilitator superfamily domain 
               
               
                   
                   
                   
                   
                 containing 6 
               
               
                 236119_s_at 
                 10.709725 
                 down 
                 SPRR2G 
                 small proline-rich protein 2G 
               
               
                 232164_s_at 
                 10.52053 
                 down 
                 EPPK1 
                 epiplakin 1 
               
               
                 207381_at 
                 10.421057 
                 down 
                 ALOX12B 
                 arachidonate 12-lipoxygenase, 12R 
               
               
                   
                   
                   
                   
                 type 
               
               
                 229764_at 
                 10.407254 
                 down 
                 TPRG1 
                 tumor protein p63 regulated 1 
               
               
                 218002_s_at 
                 10.403229 
                 down 
                 CXCL14 
                 chemokine (C—X—C motif) ligand 14 
               
               
                 227752_at 
                 10.369038 
                 down 
                 SPTLC3 
                 serine palmitoyltransferase, long chain 
               
               
                   
                   
                   
                   
                 base subunit 3 
               
               
                 206385_s_at 
                 10.252723 
                 down 
                 ANK3 
                 ankyrin 3, node of Ranvier (ankyrin G) 
               
               
                 236471_at 
                 10.205697 
                 down 
                 NFE2L3 
                 nuclear factor (erythroid-derived 2)- 
               
               
                   
                   
                   
                   
                 like 3 
               
               
                 205513_at 
                 10.141289 
                 down 
                 TCN1 
                 transcobalamin I (vitamin B12 binding 
               
               
                   
                   
                   
                   
                 protein, R binder family) 
               
               
                 219313_at 
                 10.072841 
                 down 
                 GRAMD1C 
                 GRAM domain containing 1C 
               
               
                 228575_at 
                 10.042443 
                 down 
                 IL20RB 
                 interleukin 20 receptor beta 
               
               
                 227177_at 
                 9.9979105 
                 down 
                 CORO2A 
                 coronin, actin binding protein, 2A 
               
               
                 220090_at 
                 9.935171 
                 down 
                 CRNN 
                 cornulin 
               
               
                 1556793_a_at 
                 9.737699 
                 down 
                 FAM83C 
                 family with sequence similarity 83, 
               
               
                   
                   
                   
                   
                 member C 
               
               
                 222242_s_at 
                 9.652021 
                 down 
                 KLK5 
                 kallikrein-related peptidase 5 
               
               
                 242204_at 
                 9.497831 
                 down 
                 WFDC5 
                 WAP four-disulfide core domain 5 
               
               
                 228523_at 
                 9.446722 
                 down 
                 NANOS1 
                 nanos homolog 1 ( Drosophila ) 
               
               
                 226185_at 
                 9.266244 
                 down 
                 CDS1 
                 CDP-diacylglycerol synthase 
               
               
                   
                   
                   
                   
                 (phosphatidate cytidylyltransferase) 1 
               
               
                 237690_at 
                 9.185177 
                 down 
                 GPR115 
                 G protein-coupled receptor 115 
               
               
                 214071_at 
                 9.122895 
                 down 
                 MPPE1 
                 MRNA; cDNA DKFZp686K2379 
               
               
                   
                   
                   
                   
                 (from clone DKFZp686K2379) 
               
               
                 225540_at 
                 9.112212 
                 down 
                 MAP2 
                 microtubule-associated protein 2 
               
               
                 227209_at 
                 9.101238 
                 down 
                 CNTN1 
                 Contactin 2 precursor (CNTN1) 
               
               
                 220624_s_at 
                 9.078715 
                 down 
                 ELF5 
                 E74-like factor 5 (ets domain 
               
               
                   
                   
                   
                   
                 transcription factor) 
               
               
                 243871_at 
                 9.058688 
                 down 
                 LOC100130476 
                 PREDICTED:  Homo sapiens  similar to 
               
               
                   
                   
                   
                   
                 hCG2036711 (LOC100130476), 
               
               
                   
                   
                   
                   
                 mRNA 
               
               
                 242998_at 
                 8.8784485 
                 down 
                 RDH12 
                 retinol dehydrogenase 12 (all-trans/9- 
               
               
                   
                   
                   
                   
                 cis/11-cis) 
               
               
                 219995_s_at 
                 8.86155 
                 down 
                 ZNF750 
                 zinc finger protein 750 
               
               
                 225846_at 
                 8.854407 
                 down 
                 RBM35A 
                 RNA binding motif protein 35A 
               
               
                 227747_at 
                 8.839586 
                 down 
                 MPZL3 
                 myelin protein zero-like 3 
               
               
                 213056_at 
                 8.795081 
                 down 
                 FRMD4B 
                 FERM domain containing 4B 
               
               
                 204702_s_at 
                 8.784606 
                 down 
                 NFE2L3 
                 nuclear factor (erythroid-derived 2)- 
               
               
                   
                   
                   
                   
                 like 3 
               
               
                 238017_at 
                 8.7703905 
                 down 
                 SDR16C5 
                 short chain dehydrogenase/reductase 
               
               
                   
                   
                   
                   
                 family 16C, member 5 
               
               
                 220414_at 
                 8.748902 
                 down 
                 CALML5 
                 calmodulin-like 5 
               
               
                 225792_at 
                 8.72326 
                 down 
                 HOOK1 
                 hook homolog 1 ( Drosophila ) 
               
               
                 209442_x_at 
                 8.710819 
                 down 
                 ANK3 
                 ankyrin 3, node of Ranvier (ankyrin G) 
               
               
                 204469_at 
                 8.700343 
                 down 
                 PTPRZ1 
                 protein tyrosine phosphatase, receptor- 
               
               
                   
                   
                   
                   
                 type, Z polypeptide 1 
               
               
                 226213_at 
                 8.644065 
                 down 
                 ERBB3 
                 v-erb-b2 erythroblastic leukemia viral 
               
               
                   
                   
                   
                   
                 oncogene homolog 3 (avian) 
               
               
                 205220_at 
                 8.635616 
                 down 
                 GPR109B 
                 G protein-coupled receptor 109B 
               
               
                 219369_s_at 
                 8.634883 
                 down 
                 OTUB2 
                 OTU domain, ubiquitin aldehyde 
               
               
                   
                   
                   
                   
                 binding 2 
               
               
                 206595_at 
                 8.616346 
                 down 
                 CST6 
                 cystatin E/M 
               
               
                 1556361_s_at 
                 8.6023035 
                 down 
                 ANKRD13C 
                 ankyrin repeat domain 13C 
               
               
                 1559226_x_at 
                 8.588551 
                 down 
                 LCE1E 
                 late cornified envelope 1E 
               
               
                 243582_at 
                 8.550055 
                 down 
                 SH3RF2 
                 SH3 domain containing ring finger 2 
               
               
                 221666_s_at 
                 8.532053 
                 down 
                 PYCARD 
                 PYD and CARD domain containing 
               
               
                 204455_at 
                 8.512845 
                 down 
                 DST 
                 dystonin 
               
               
                 201348_at 
                 8.504907 
                 down 
                 GPX3 
                 glutathione peroxidase 3 (plasma) 
               
               
                 212538_at 
                 8.472947 
                 down 
                 DOCK9 
                 dedicator of cytokinesis 9 
               
               
                 211361_s_at 
                 8.422554 
                 down 
                 SERPINB13 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 13 
               
               
                 205969_at 
                 8.273929 
                 down 
                 AADAC 
                 arylacetamide deacetylase (esterase) 
               
               
                 220013_at 
                 8.225659 
                 down 
                 ABHD9 
                 abhydrolase domain containing 9 
               
               
                 219756_s_at 
                 8.173803 
                 down 
                 POF1B 
                 premature ovarian failure, 1B 
               
               
                 230349_at 
                 8.170966 
                 down 
                 XKRX 
                 XK, Kell blood group complex 
               
               
                   
                   
                   
                   
                 subunit-related, X-linked 
               
               
                 238654_at 
                 8.165287 
                 down 
                 LOC147645 
                 hypothetical protein LOC147645 
               
               
                 220723_s_at 
                 8.1235 
                 down 
                 FLJ21511 
                 hypothetical protein FLJ21511 
               
               
                 225325_at 
                 8.100503 
                 down 
                 MFSD6 
                 major facilitator superfamily domain 
               
               
                   
                   
                   
                   
                 containing 6 
               
               
                 236514_at 
                 8.063193 
                 down 
                 ACOT8 
                 HIV-Nef associated acyl CoA 
               
               
                   
                   
                   
                   
                 thioesterase (hNAACTE) 
               
               
                 224650_at 
                 7.978321 
                 down 
                 MAL2 
                 mal, T-cell differentiation protein 2 
               
               
                 205709_s_at 
                 7.964628 
                 down 
                 CDS1 
                 CDP-diacylglycerol synthase 
               
               
                   
                   
                   
                   
                 (phosphatidate cytidylyltransferase) 1 
               
               
                 215704_at 
                 7.9460135 
                 down 
                 FLG 
                 PLAC2 placenta-specific 2 (non- 
               
               
                   
                   
                   
                   
                 protein coding) 
               
               
                 223544_at 
                 7.941029 
                 down 
                 TMEM79 
                 transmembrane protein 79 
               
               
                 243722_at 
                 7.872192 
                 down 
                 PYDC1 
                 PYD (pyrin domain) containing 1 
               
               
                 206642_at 
                 7.8642535 
                 down 
                 DSG1 
                 desmoglein 1 
               
               
                 204952_at 
                 7.8289723 
                 down 
                 LYPD3 
                 LY6/PLAUR domain containing 3 
               
               
                 217087_at 
                 7.8114066 
                 down 
                 C1orf68 
                 chromosome 1 open reading frame 68 
               
               
                 222549_at 
                 7.7580996 
                 down 
                 CLDN1 
                 claudin 1 
               
               
                 229385_s_at 
                 7.6575327 
                 down 
                 PLAC2 
                 placenta-specific 2 (non-protein 
               
               
                   
                   
                   
                   
                 coding) 
               
               
                 219267_at 
                 7.655961 
                 down 
                 GLTP 
                 glycolipid transfer protein 
               
               
                 217272_s_at 
                 7.6130595 
                 down 
                 SERPINB13 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 13 
               
               
                 1555383_a_at 
                 7.5732036 
                 down 
                 POF1B 
                 premature ovarian failure, 1B 
               
               
                 238028_at 
                 7.5382996 
                 down 
                 LOC100128918 
                 hypothetical protein LOC100128918 
               
               
                 1552502_s_at 
                 7.5355606 
                 down 
                 RHBDL2 
                 rhomboid, veinlet-like 2 ( Drosophila ) 
               
               
                 205568_at 
                 7.4951296 
                 down 
                 AQP9 
                 aquaporin 9 
               
               
                 205442_at 
                 7.491568 
                 down 
                 MFAP3L 
                 microfibrillar-associated protein 3-like 
               
               
                 227955_s_at 
                 7.4095197 
                 down 
                 EFNA5 
                 ephrin-A5 
               
               
                 210833_at 
                 7.343155 
                 down 
                 PTGER3 
                 prostaglandin E receptor 3 (subtype 
               
               
                   
                   
                   
                   
                 EP3) 
               
               
                 212543_at 
                 7.342191 
                 down 
                 AIM1 
                 absent in melanoma 1 
               
               
                 218186_at 
                 7.3316717 
                 down 
                 RAB25 
                 RAB25, member RAS oncogene 
               
               
                   
                   
                   
                   
                 family 
               
               
                 219403_s_at 
                 7.320557 
                 down 
                 HPSE 
                 heparanase 
               
               
                 210074_at 
                 7.306036 
                 down 
                 CTSL2 
                 cathepsin L2 
               
               
                 219850_s_at 
                 7.2735214 
                 down 
                 EHF 
                 ets homologous factor 
               
               
                 228708_at 
                 7.271517 
                 down 
                 RAB27B 
                 Small GTP-binding protein Rab27b 
               
               
                 227202_at 
                 7.2712536 
                 down 
                 CNTN1 
                 Contactin 2 precursor (CNTN1) 
               
               
                 228538_at 
                 7.258556 
                 down 
                 ZNF662 
                 zinc finger protein 662 
               
               
                 232158_x_at 
                 7.256812 
                 down 
                 NPAL1 
                 NIPA-like domain containing 1 
               
               
                 226803_at 
                 7.2564917 
                 down 
                 CHMP4C 
                 chromatin modifying protein 4C 
               
               
                 206488_s_at 
                 7.236786 
                 down 
                 CD36 
                 CD36 molecule (thrombospondin 
               
               
                   
                   
                   
                   
                 receptor) 
               
               
                 218035_s_at 
                 7.19059 
                 down 
                 RBM47 
                 RNA binding motif protein 47 
               
               
                 205185_at 
                 7.1835594 
                 down 
                 SPINK5 
                 serine peptidase inhibitor, Kazal type 5 
               
               
                 206115_at 
                 7.160374 
                 down 
                 EGR3 
                 early growth response 3 
               
               
                 221854_at 
                 7.152312 
                 down 
                 PKP1 
                 plakophilin 1 (ectodermal 
               
               
                   
                   
                   
                   
                 dysplasia/skin fragility syndrome) 
               
               
                 239770_at 
                 7.1368814 
                 down 
                 FAM62C 
                 family with sequence similarity 62 (C2 
               
               
                   
                   
                   
                   
                 domain containing), member C 
               
               
                 214091_s_at 
                 7.1271777 
                 down 
                 GPX3 
                 glutathione peroxidase 3 (plasma) 
               
               
                 218764_at 
                 7.120812 
                 down 
                 PRKCH 
                 protein kinase C, eta 
               
               
                 214536_at 
                 7.1027665 
                 down 
                 SLURP1 
                 secreted LY6/PLAUR domain 
               
               
                   
                   
                   
                   
                 containing 1 
               
               
                 222496_s_at 
                 7.0082264 
                 down 
                 RBM47 
                 RNA binding motif protein 47 
               
               
                 232056_at 
                 7.0050087 
                 down 
                 SCEL 
                 sciellin 
               
               
                 217496_s_at 
                 6.950076 
                 down 
                 IDE 
                 insulin-degrading enzyme 
               
               
                 215465_at 
                 6.9448395 
                 down 
                 ABCA12 
                 ATP-binding cassette, sub-family A 
               
               
                   
                   
                   
                   
                 (ABC1), member 12 
               
               
                 229070_at 
                 6.942199 
                 down 
                 C6orf105 
                 chromosome 6 open reading frame 105 
               
               
                 208937_s_at 
                 6.8969717 
                 down 
                 ID1 
                 inhibitor of DNA binding 1, dominant 
               
               
                   
                   
                   
                   
                 negative helix-loop-helix protein 
               
               
                 219630_at 
                 6.8924527 
                 down 
                 PDZK1IP1 
                 PDZK1 interacting protein 1 
               
               
                 1553454_at 
                 6.8833647 
                 down 
                 RPTN 
                 repetin 
               
               
                 1553589_a_at 
                 6.879349 
                 down 
                 PDZK1IP1 
                 PDZK1 interacting protein 1 
               
               
                 219388_at 
                 6.834852 
                 down 
                 GRHL2 
                 grainyhead-like 2 ( Drosophila ) 
               
               
                 207326_at 
                 6.8310184 
                 down 
                 BTC 
                 betacellulin 
               
               
                 228038_at 
                 6.8282814 
                 down 
                 SOX2 
                 SRY (sex determining region Y)-box 2 
               
               
                 36499_at 
                 6.82723 
                 down 
                 CELSR2 
                 cadherin, EGF LAG seven-pass G-type 
               
               
                   
                   
                   
                   
                 receptor 2 (flamingo homolog, 
               
               
                   
                   
                   
                   
                   Drosophila ) 
               
               
                 231148_at 
                 6.815531 
                 down 
                 IGFL2 
                 IGF-like family member 2 
               
               
                 213611_at 
                 6.770561 
                 down 
                 AQP5 
                 aquaporin 5 
               
               
                 231849_at 
                 6.6379747 
                 down 
                 KRT80 
                 keratin 80 
               
               
                 226535_at 
                 6.6363 
                 down 
                 ITGB6 
                 integrin, beta 6 
               
               
                 204942_s_at 
                 6.622183 
                 down 
                 ALDH3B2 
                 aldehyde dehydrogenase 3 family, 
               
               
                   
                   
                   
                   
                 member B2 
               
               
                 203178_at 
                 6.615657 
                 down 
                 GATM 
                 glycine amidinotransferase (L- 
               
               
                   
                   
                   
                   
                 arginine:glycine amidinotransferase) 
               
               
                 1557136_at 
                 6.601717 
                 down 
                 ATP13A4 
                 ATPase type 13A4 
               
               
                 213927_at 
                 6.5928116 
                 down 
                 MAP3K9 
                 mitogen-activated protein kinase 
               
               
                   
                   
                   
                   
                 kinase kinase 9 
               
               
                 220945_x_at 
                 6.560972 
                 down 
                 MANSC1 
                 MANSC domain containing 1 
               
               
                 206125_s_at 
                 6.5505314 
                 down 
                 KLK8 
                 kallikrein-related peptidase 8 
               
               
                 202712_s_at 
                 6.507372 
                 down 
                 CKMT1A /// 
                 creatine kinase, mitochondrial 1A /// 
               
               
                   
                   
                   
                 CKMT1B /// 
                 creatine kinase, mitochondrial 1B /// 
               
               
                   
                   
                   
                 LOC100133623 
                 similar to Creatine kinase, ubiquitous 
               
               
                   
                   
                   
                   
                 mitochondrial precursor (U-MtCK) 
               
               
                   
                   
                   
                   
                 (Mia-CK) (Acidic-type mitochondrial 
               
               
                   
                   
                   
                   
                 creatine kinase) 
               
               
                 1561225_at 
                 6.4982934 
                 down 
                 LOC338579 
                 hypothetical protein LOC338579 
               
               
                 224189_x_at 
                 6.491583 
                 down 
                 EHF 
                 ets homologous factor 
               
               
                 211788_s_at 
                 6.4853163 
                 down 
                 TREX2 
                 three prime repair exonuclease 2 
               
               
                 203180_at 
                 6.4791126 
                 down 
                 ALDH1A3 
                 aldehyde dehydrogenase 1 family, 
               
               
                   
                   
                   
                   
                 member A3 
               
               
                 1555890_at 
                 6.4574604 
                 down 
                 OR2A20P /// 
                 olfactory receptor, family 2, subfamily 
               
               
                   
                   
                   
                 OR2A9P 
                 A, member 20 pseudogene /// olfactory 
               
               
                   
                   
                   
                   
                 receptor, family 2, subfamily A, 
               
               
                   
                   
                   
                   
                 member 9 pseudogene 
               
               
                 226482_s_at 
                 6.4535813 
                 down 
                 hCG_20857 
                 thiosulfate sulfurtransferase KAT, 
               
               
                   
                   
                   
                 /// RP11- 
                 putative /// KAT protein 
               
               
                   
                   
                   
                 544M22.4 
               
               
                 208156_x_at 
                 6.4456053 
                 down 
                 EPPK1 
                 epiplakin 1 
               
               
                 228948_at 
                 6.4166746 
                 down 
                 EPHA4 
                 EPH receptor A4 
               
               
                 223658_at 
                 6.402442 
                 down 
                 KCNK6 
                 potassium channel, subfamily K, 
               
               
                   
                   
                   
                   
                 member 6 
               
               
                 230179_at 
                 6.3794336 
                 down 
                 LOC285812 
                 hypothetical protein LOC285812 
               
               
                 1554253_a_at 
                 6.3690333 
                 down 
                 LASS3 
                 LAG1 homolog, ceramide synthase 3 
               
               
                 240304_s_at 
                 6.356037 
                 down 
                 TMC5 
                 transmembrane channel-like 5 
               
               
                 207109_at 
                 6.272226 
                 down 
                 POU2F3 
                 POU class 2 homeobox 3 
               
               
                 206114_at 
                 6.2673965 
                 down 
                 EPHA4 
                 EPH receptor A4 
               
               
                 219232_s_at 
                 6.265491 
                 down 
                 EGLN3 
                 egl nine homolog 3 ( C. elegans ) 
               
               
                 41469_at 
                 6.259633 
                 down 
                 PI3 
                 peptidase inhibitor 3, skin-derived 
               
               
                 238710_at 
                 6.2384377 
                 down 
                 TMEM86A 
                 transmembrane protein 86A 
               
               
                 202193_at 
                 6.232698 
                 down 
                 LIMK2 
                 LIM domain kinase 2 
               
               
                 220664_at 
                 6.2243595 
                 down 
                 SPRR2C 
                 small proline-rich protein 2C 
               
               
                   
                   
                   
                   
                 (pseudogene) 
               
               
                 203021_at 
                 6.1999464 
                 down 
                 SLPI 
                 secretory leukocyte peptidase inhibitor 
               
               
                 210461_s_at 
                 6.1930823 
                 down 
                 ABLIM1 
                 actin binding LIM protein 1 
               
               
                 210015_s_at 
                 6.163196 
                 down 
                 MAP2 
                 microtubule-associated protein 2 
               
               
                 206392_s_at 
                 6.1626806 
                 down 
                 RARRES1 
                 retinoic acid receptor responder 
               
               
                   
                   
                   
                   
                 (tazarotene induced) 1 
               
               
                 212570_at 
                 6.1608458 
                 down 
                 ENDOD1 
                 endonuclease domain containing 1 
               
               
                 214070_s_at 
                 6.1544147 
                 down 
                 ATP10B 
                 ATPase, class V, type 10B 
               
               
                 226863_at 
                 6.136124 
                 down 
                 FAM110C 
                 family with sequence similarity 110, 
               
               
                   
                   
                   
                   
                 member C 
               
               
                 207192_at 
                 6.1150155 
                 down 
                 DNASE1L2 
                 deoxyribonuclease I-like 2 
               
               
                 215125_s_at 
                 6.1119647 
                 down 
                 UGT1A1 /// 
                 UDP glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A10 /// 
                 polypeptide A1 /// UDP 
               
               
                   
                   
                   
                 UGT1A3 /// 
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A4 /// 
                 polypeptide A10 /// UDP 
               
               
                   
                   
                   
                 UGT1A5 /// 
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A6 /// 
                 polypeptide A3 /// UDP 
               
               
                   
                   
                   
                 UGT1A7 /// 
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A8 /// 
                 polypeptide A4 /// UDP 
               
               
                   
                   
                   
                 UGT1A9 
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A5 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A6 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A7 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A8 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A9 
               
               
                 1554921_a_at 
                 6.0999765 
                 down 
                 SCEL 
                 sciellin 
               
               
                 225645_at 
                 6.0821557 
                 down 
                 EHF 
                 Ets homologous factor, mRNA (cDNA 
               
               
                   
                   
                   
                   
                 clone MGC: 47678 IMAGE: 6055934) 
               
               
                 219936_s_at 
                 6.0806403 
                 down 
                 GPR87 
                 G protein-coupled receptor 87 
               
               
                 219532_at 
                 6.073317 
                 down 
                 ELOVL4 
                 elongation of very long chain fatty 
               
               
                   
                   
                   
                   
                 acids (FEN1/Elo2, SUR4/Elo3, yeast)- 
               
               
                   
                   
                   
                   
                 like 4 
               
               
                 216258_s_at 
                 6.0713954 
                 down 
                 SERPINB13 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 13 
               
               
                 203328_x_at 
                 6.0695624 
                 down 
                 IDE 
                 insulin-degrading enzyme 
               
               
                 230323_s_at 
                 6.0668006 
                 down 
                 TMEM45B 
                 transmembrane protein 45B 
               
               
                 227180_at 
                 6.0664496 
                 down 
                 ELOVL7 
                 ELOVL family member 7, elongation 
               
               
                   
                   
                   
                   
                 of long chain fatty acids (yeast) 
               
               
                 219497_s_at 
                 6.0622134 
                 down 
                 BCL11A 
                 B-cell CLL/lymphoma 11A (zinc 
               
               
                   
                   
                   
                   
                 finger protein) 
               
               
                 212560_at 
                 6.057562 
                 down 
                 SORL1 
                 sortilin-related receptor, L(DLR class) 
               
               
                   
                   
                   
                   
                 A repeats-containing 
               
               
                 216074_x_at 
                 6.0346746 
                 down 
                 WWC1 
                 WW and C2 domain containing 1 
               
               
                 210117_at 
                 6.022336 
                 down 
                 SPAG1 
                 sperm associated antigen 1 
               
               
                 221872_at 
                 5.9994154 
                 down 
                 RARRES1 
                 retinoic acid receptor responder 
               
               
                   
                   
                   
                   
                 (tazarotene induced) 1 
               
               
                 238096_at 
                 5.9605427 
                 down 
                 LOC284023 
                 hypothetical protein LOC284023 
               
               
                 209603_at 
                 5.944856 
                 down 
                 GATA3 
                 GATA binding protein 3 
               
               
                 215554_at 
                 5.9089704 
                 down 
                 GPLD1 
                 glycosylphosphatidylinositol specific 
               
               
                   
                   
                   
                   
                 phospholipase D1 
               
               
                 203691_at 
                 5.895547 
                 down 
                 PI3 
                 peptidase inhibitor 3, skin-derived 
               
               
                 210130_s_at 
                 5.889496 
                 down 
                 TM7SF2 
                 transmembrane 7 superfamily member 2 
               
               
                 1553989_a_at 
                 5.889157 
                 down 
                 ATP6V1C2 
                 ATPase, H+ transporting, lysosomal 
               
               
                   
                   
                   
                   
                 42 kDa, V1 subunit C2 
               
               
                 235230_at 
                 5.864316 
                 down 
                 PLCXD2 
                 phosphatidylinositol-specific 
               
               
                   
                   
                   
                   
                 phospholipase C, X domain containing 2 
               
               
                 1554897_s_at 
                 5.809435 
                 down 
                 RHBDL2 
                 rhomboid, veinlet-like 2 ( Drosophila ) 
               
               
                 236172_at 
                 5.80707 
                 down 
                 LTB4R 
                 leukotriene B4 receptor 
               
               
                 228865_at 
                 5.8040857 
                 down 
                 C1orf116 
                 chromosome 1 open reading frame 116 
               
               
                 223659_at 
                 5.8040533 
                 down 
                 TMPRSS13 
                 transmembrane protease, serine 13 
               
               
                 205778_at 
                 5.800858 
                 down 
                 KLK7 
                 kallikrein-related peptidase 7 
               
               
                 219529_at 
                 5.7376733 
                 down 
                 CLIC3 
                 chloride intracellular channel 3 
               
               
                 216615_s_at 
                 5.662501 
                 down 
                 HTR3A 
                 5-hydroxytryptamine (serotonin) 
               
               
                   
                   
                   
                   
                 receptor 3A 
               
               
                 238567_at 
                 5.6408434 
                 down 
                 SGPP2 
                 sphingosine-1-phosphate phosphotase 2 
               
               
                 206165_s_at 
                 5.6202765 
                 down 
                 CLCA2 
                 chloride channel regulator 2 
               
               
                 206008_at 
                 5.6143503 
                 down 
                 TGM1 
                 transglutaminase 1 (K polypeptide 
               
               
                   
                   
                   
                   
                 epidermal type I, protein-glutamine- 
               
               
                   
                   
                   
                   
                 gamma-glutamyltransferase) 
               
               
                 211906_s_at 
                 5.612926 
                 down 
                 SERPINB4 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 4 
               
               
                 235955_at 
                 5.6074624 
                 down 
                 MARVELD2 
                 MARVEL domain containing 2 
               
               
                 206214_at 
                 5.594604 
                 down 
                 PLA2G7 
                 phospholipase A2, group VII (platelet- 
               
               
                   
                   
                   
                   
                 activating factor acetylhydrolase, 
               
               
                   
                   
                   
                   
                 plasma) 
               
               
                 202286_s_at 
                 5.5906916 
                 down 
                 TACSTD2 
                 tumor-associated calcium signal 
               
               
                   
                   
                   
                   
                 transducer 2 
               
               
                 206164_at 
                 5.5694885 
                 down 
                 CLCA2 
                 chloride channel regulator 2 
               
               
                 239381_at 
                 5.5625143 
                 down 
                 KLK7 
                 kallikrein-related peptidase 7 
               
               
                 227014_at 
                 5.5577726 
                 down 
                 ASPHD2 
                 aspartate beta-hydroxylase domain 
               
               
                   
                   
                   
                   
                 containing 2 
               
               
                 208539_x_at 
                 5.553559 
                 down 
                 SPRR2B 
                 small proline-rich protein 2B 
               
               
                 222847_s_at 
                 5.53052 
                 down 
                 EGLN3 
                 egl nine homolog 3 ( C. elegans ) 
               
               
                 227450_at 
                 5.5204797 
                 down 
                 ERP27 
                 endoplasmic reticulum protein 27 kDa 
               
               
                 225615_at 
                 5.499722 
                 down 
                 IFFO2 
                 intermediate filament family orphan 2 
               
               
                 219461_at 
                 5.4821987 
                 down 
                 PAK6 
                 p21 protein (Cdc42/Rac)-activated 
               
               
                   
                   
                   
                   
                 kinase 6 
               
               
                 206683_at 
                 5.4811287 
                 down 
                 ZNF165 
                 zinc finger protein 165 
               
               
                 1555310_a_at 
                 5.4699154 
                 down 
                 PAK6 
                 p21 protein (Cdc42/Rac)-activated 
               
               
                   
                   
                   
                   
                 kinase 6 
               
               
                 242828_at 
                 5.4434 
                 down 
                 FIGN 
                 fidgetin 
               
               
                 224329_s_at 
                 5.4422174 
                 down 
                 CNFN 
                 cornifelin 
               
               
                 219998_at 
                 5.4138575 
                 down 
                 HSPC159 
                 galectin-related protein 
               
               
                 33767_at 
                 5.4136043 
                 down 
                 NEFH 
                 neurofilament, heavy polypeptide 
               
               
                 205363_at 
                 5.4128237 
                 down 
                 BBOX1 
                 butyrobetaine (gamma), 2-oxoglutarate 
               
               
                   
                   
                   
                   
                 dioxygenase (gamma-butyrobetaine 
               
               
                   
                   
                   
                   
                 hydroxylase) 1 
               
               
                 211597_s_at 
                 5.409704 
                 down 
                 HOPX 
                 HOP homeobox 
               
               
                 203962_s_at 
                 5.383551 
                 down 
                 NEBL 
                 nebulette 
               
               
                 206032_at 
                 5.376959 
                 down 
                 DSC3 
                 desmocollin 3 
               
               
                 227570_at 
                 5.3740797 
                 down 
                 TMEM86A 
                 transmembrane protein 86A 
               
               
                 226926_at 
                 5.3653264 
                 down 
                 DMKN 
                 dermokine 
               
               
                 202191_s_at 
                 5.363796 
                 down 
                 GAS7 
                 growth arrest-specific 7 
               
               
                 206482_at 
                 5.34657 
                 down 
                 PTK6 
                 PTK6 protein tyrosine kinase 6 
               
               
                 223611_s_at 
                 5.3417473 
                 down 
                 LNX1 
                 ligand of numb-protein X 1 
               
               
                 204379_s_at 
                 5.287966 
                 down 
                 FGFR3 
                 fibroblast growth factor receptor 3 
               
               
                 212992_at 
                 5.2794547 
                 down 
                 AHNAK2 
                 AHNAK nucleoprotein 2 
               
               
                 217528_at 
                 5.258966 
                 down 
                 CLCA2 
                 chloride channel regulator 2 
               
               
                 236534_at 
                 5.2476907 
                 down 
                 BNIPL 
                 BCL2/adenovirus E1B 19 kD 
               
               
                   
                   
                   
                   
                 interacting protein like 
               
               
                 201131_s_at 
                 5.239927 
                 down 
                 CDH1 
                 cadherin 1, type 1, E-cadherin 
               
               
                   
                   
                   
                   
                 (epithelial) 
               
               
                 235099_at 
                 5.228119 
                 down 
                 CMTM8 
                 CKLF-like MARVEL transmembrane 
               
               
                   
                   
                   
                   
                 domain containing 8 
               
               
                 226755_at 
                 5.2196016 
                 down 
                 LOC642587 
                 CDNA FLJ33794 fis, clone 
               
               
                   
                   
                   
                   
                 CTONG1000009 
               
               
                 235146_at 
                 5.2194705 
                 down 
                 TMCC3 
                 transmembrane and coiled-coil domain 
               
               
                   
                   
                   
                   
                 family 3 
               
               
                 1554593_s_at 
                 5.2057705 
                 down 
                 SLC1A6 
                 solute carrier family 1 (high affinity 
               
               
                   
                   
                   
                   
                 aspartate/glutamate transporter), 
               
               
                   
                   
                   
                   
                 member 6 
               
               
                 205832_at 
                 5.1992483 
                 down 
                 CPA4 
                 carboxypeptidase A4 
               
               
                 213085_s_at 
                 5.183778 
                 down 
                 WWC1 
                 WW and C2 domain containing 1 
               
               
                 229518_at 
                 5.179313 
                 down 
                 FAM46B 
                 family with sequence similarity 46, 
               
               
                   
                   
                   
                   
                 member B 
               
               
                 226177_at 
                 5.172866 
                 down 
                 GLTP 
                 glycolipid transfer protein 
               
               
                 200862_at 
                 5.170659 
                 down 
                 DHCR24 
                 24-dehydrocholesterol reductase 
               
               
                 212242_at 
                 5.147954 
                 down 
                 TUBA4A 
                 tubulin, alpha 4a 
               
               
                 242103_at 
                 5.142739 
                 down 
                 TMEM86A 
                 transmembrane protein 86A 
               
               
                 206166_s_at 
                 5.137547 
                 down 
                 CLCA2 
                 chloride channel regulator 2 
               
               
                 210715_s_at 
                 5.117244 
                 down 
                 SPINT2 
                 serine peptidase inhibitor, Kunitz type, 2 
               
               
                 1554912_at 
                 5.1171923 
                 down 
                 FAM62C 
                 family with sequence similarity 62 (C2 
               
               
                   
                   
                   
                   
                 domain containing), member C 
               
               
                 1553077_at 
                 5.116311 
                 down 
                 SDR9C7 
                 short chain dehydrogenase/reductase 
               
               
                   
                   
                   
                   
                 family 9C, member 7 
               
               
                 206628_at 
                 5.108023 
                 down 
                 SLC5A1 
                 solute carrier family 5 (sodium/glucose 
               
               
                   
                   
                   
                   
                 cotransporter), member 1 
               
               
                 228698_at 
                 5.09854 
                 down 
                 SOX7 
                 SRY (sex determining region Y)-box 7 
               
               
                 220161_s_at 
                 5.089994 
                 down 
                 EPB41L4B 
                 erythrocyte membrane protein band 4.1 
               
               
                   
                   
                   
                   
                 like 4B 
               
               
                 202421_at 
                 5.073653 
                 down 
                 IGSF3 
                 immunoglobulin superfamily, member 3 
               
               
                 238909_at 
                 5.0720587 
                 down 
                 S100A10 
                 Calpactin I light chain, 5′UTR region 
               
               
                 225299_at 
                 5.0482273 
                 down 
                 MYO5B 
                 myosin VB 
               
               
                 235141_at 
                 5.0444136 
                 down 
                 MARVELD2 
                 MARVEL domain containing 2 
               
               
                 201236_s_at 
                 5.0438776 
                 down 
                 BTG2 
                 BTG family, member 2 
               
               
                 1555382_at 
                 5.0425205 
                 down 
                 POF1B 
                 premature ovarian failure, 1B 
               
               
                 1557094_at 
                 5.0291085 
                 down 
                 LOC653110 
                 hypothetical LOC653110 
               
               
                 201243_s_at 
                 5.024576 
                 down 
                 ATP1B1 
                 ATPase, Na+/K+ transporting, beta 1 
               
               
                   
                   
                   
                   
                 polypeptide 
               
               
                 207114_at 
                 5.0127378 
                 down 
                 LY6G6C 
                 lymphocyte antigen 6 complex, locus 
               
               
                   
                   
                   
                   
                 G6C 
               
               
                 227676_at 
                 4.999608 
                 down 
                 FAM3D 
                 family with sequence similarity 3, 
               
               
                   
                   
                   
                   
                 member D 
               
               
                 219680_at 
                 4.998101 
                 down 
                 NLRX1 
                 NLR family member X1 
               
               
                 202295_s_at 
                 4.9733486 
                 down 
                 CTSH 
                 cathepsin H 
               
               
                 206561_s_at 
                 4.97185 
                 down 
                 AKR1B10 
                 aldo-keto reductase family 1, member 
               
               
                   
                   
                   
                   
                 B10 (aldose reductase) 
               
               
                 218717_s_at 
                 4.965496 
                 down 
                 LEPREL1 
                 leprecan-like 1 
               
               
                 209212_s_at 
                 4.9630527 
                 down 
                 KLF5 
                 Kruppel-like factor 5 (intestinal) 
               
               
                 207414_s_at 
                 4.9624557 
                 down 
                 PCSK6 
                 proprotein convertase subtilisin/kexin 
               
               
                   
                   
                   
                   
                 type 6 
               
               
                 242271_at 
                 4.962056 
                 down 
                 SLC26A9 
                 solute carrier family 26, member 9 
               
               
                 216918_s_at 
                 4.960929 
                 down 
                 DST 
                 dystonin 
               
               
                 204855_at 
                 4.9595795 
                 down 
                 SERPINB5 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 5 
               
               
                 1553929_at 
                 4.9470873 
                 down 
                 ACER1 
                 alkaline ceramidase 1 
               
               
                 203961_at 
                 4.92486 
                 down 
                 NEBL 
                 nebulette 
               
               
                 205807_s_at 
                 4.9016848 
                 down 
                 TUFT1 
                 tuftelin 1 
               
               
                 203453_at 
                 4.897337 
                 down 
                 SCNN1A 
                 sodium channel, nonvoltage-gated 1 
               
               
                   
                   
                   
                   
                 alpha 
               
               
                 222383_s_at 
                 4.875127 
                 down 
                 ALOXE3 
                 arachidonate lipoxygenase 3 
               
               
                 1552319_a_at 
                 4.8667984 
                 down 
                 KLK8 
                 kallikrein-related peptidase 8 
               
               
                 216733_s_at 
                 4.8367143 
                 down 
                 GATM 
                 glycine amidinotransferase (L- 
               
               
                   
                   
                   
                   
                 arginine:glycine amidinotransferase) 
               
               
                 208153_s_at 
                 4.819246 
                 down 
                 FAT2 
                 FAT tumor suppressor homolog 2 
               
               
                   
                   
                   
                   
                 ( Drosophila ) 
               
               
                 1559224_at 
                 4.81139 
                 down 
                 LCE1E 
                 late cornified envelope 1E 
               
               
                 222892_s_at 
                 4.811261 
                 down 
                 TMEM40 
                 transmembrane protein 40 
               
               
                 213992_at 
                 4.8003573 
                 down 
                 COL4A6 
                 collagen, type IV, alpha 6 
               
               
                 206023_at 
                 4.7886114 
                 down 
                 NMU 
                 neuromedin U 
               
               
                 214734_at 
                 4.7853513 
                 down 
                 EXPH5 
                 exophilin 5 
               
               
                 60474_at 
                 4.7850847 
                 down 
                 FERMT1 
                 fermitin family homolog 1 
               
               
                   
                   
                   
                   
                 ( Drosophila ) 
               
               
                 219498_s_at 
                 4.7693014 
                 down 
                 BCL11A 
                 B-cell CLL/lymphoma 11A (zinc 
               
               
                   
                   
                   
                   
                 finger protein) 
               
               
                 59625_at 
                 4.763774 
                 down 
                 NOL3 
                 nucleolar protein 3 (apoptosis repressor 
               
               
                   
                   
                   
                   
                 with CARD domain) 
               
               
                 202179_at 
                 4.7527394 
                 down 
                 BLMH 
                 bleomycin hydrolase 
               
               
                 236128_at 
                 4.73937 
                 down 
                 ZNF91 
                 zinc finger protein 91 
               
               
                 203642_s_at 
                 4.735424 
                 down 
                 COBLL1 
                 COBL-like 1 
               
               
                 205011_at 
                 4.726828 
                 down 
                 VWA5A 
                 von Willebrand factor A domain 
               
               
                   
                   
                   
                   
                 containing 5A 
               
               
                 203407_at 
                 4.7218986 
                 down 
                 PPL 
                 periplakin 
               
               
                 205590_at 
                 4.7012725 
                 down 
                 RASGRP1 
                 RAS guanyl releasing protein 1 
               
               
                   
                   
                   
                   
                 (calcium and DAG-regulated) 
               
               
                 222603_at 
                 4.700272 
                 down 
                 ERMP1 
                 endoplasmic reticulum 
               
               
                   
                   
                   
                   
                 metallopeptidase 1 
               
               
                 203779_s_at 
                 4.6950703 
                 down 
                 MPZL2 
                 myelin protein zero-like 2 
               
               
                 210834_s_at 
                 4.694923 
                 down 
                 PTGER3 
                 prostaglandin E receptor 3 (subtype 
               
               
                   
                   
                   
                   
                 EP3) 
               
               
                 223484_at 
                 4.6944065 
                 down 
                 C15orf48 
                 chromosome 15 open reading frame 48 
               
               
                 206033_s_at 
                 4.676169 
                 down 
                 DSC3 
                 desmocollin 3 
               
               
                 232306_at 
                 4.6732864 
                 down 
                 CDH26 
                 cadherin-like 26 
               
               
                 215808_at 
                 4.67278 
                 down 
                 KLK10 
                 kallikrein-related peptidase 10 
               
               
                 202411_at 
                 4.671116 
                 down 
                 IFI27 
                 interferon, alpha-inducible protein 27 
               
               
                 207802_at 
                 4.665757 
                 down 
                 CRISP3 
                 cysteine-rich secretory protein 3 
               
               
                 221667_s_at 
                 4.658692 
                 down 
                 HSPB8 
                 heat shock 22 kDa protein 8 
               
               
                 219087_at 
                 4.6529336 
                 down 
                 ASPN 
                 asporin 
               
               
                 218741_at 
                 4.6508865 
                 down 
                 CENPM 
                 centromere protein M 
               
               
                 203741_s_at 
                 4.6428866 
                 down 
                 ADCY7 
                 adenylate cyclase 7 
               
               
                 203074_at 
                 4.63983 
                 down 
                 ANXA8 /// 
                 annexin A8 /// annexin A8-like 1 /// 
               
               
                   
                   
                   
                 ANXA8L1 /// 
                 annexin A8-like 2 
               
               
                   
                   
                   
                 ANXA8L2 
               
               
                 201286_at 
                 4.6295676 
                 down 
                 SDC1 
                 syndecan 1 
               
               
                 231733_at 
                 4.617893 
                 down 
                 CARD18 
                 caspase recruitment domain family, 
               
               
                   
                   
                   
                   
                 member 18 
               
               
                 209873_s_at 
                 4.6149898 
                 down 
                 PKP3 
                 plakophilin 3 
               
               
                 212573_at 
                 4.6098948 
                 down 
                 ENDOD1 
                 endonuclease domain containing 1 
               
               
                 244780_at 
                 4.60221 
                 down 
                 SGPP2 
                 sphingosine-1-phosphate phosphotase 2 
               
               
                 225177_at 
                 4.5943675 
                 down 
                 RAB11FIP1 
                 RAB11 family interacting protein 1 
               
               
                   
                   
                   
                   
                 (class I) 
               
               
                 223322_at 
                 4.591433 
                 down 
                 RASSF5 
                 Ras association (RalGDS/AF-6) 
               
               
                   
                   
                   
                   
                 domain family member 5 
               
               
                 227309_at 
                 4.5890346 
                 down 
                 YOD1 
                 YOD1 OTU deubiquinating enzyme 1 
               
               
                   
                   
                   
                   
                 homolog ( S. cerevisiae ) 
               
               
                 206515_at 
                 4.587165 
                 down 
                 CYP4F3 
                 cytochrome P450, family 4, subfamily 
               
               
                   
                   
                   
                   
                 F, polypeptide 3 
               
               
                 204995_at 
                 4.5868692 
                 down 
                 CDK5R1 
                 cyclin-dependent kinase 5, regulatory 
               
               
                   
                   
                   
                   
                 subunit 1 (p35) 
               
               
                 202826_at 
                 4.585347 
                 down 
                 SPINT1 
                 serine peptidase inhibitor, Kunitz type 1 
               
               
                 205651_x_at 
                 4.5728 
                 down 
                 RAPGEF4 
                 Rap guanine nucleotide exchange 
               
               
                   
                   
                   
                   
                 factor (GEF) 4 
               
               
                 222746_s_at 
                 4.5700636 
                 down 
                 BSPRY 
                 B-box and SPRY domain containing 
               
               
                 219722_s_at 
                 4.555332 
                 down 
                 GDPD3 
                 glycerophosphodiester 
               
               
                   
                   
                   
                   
                 phosphodiesterase domain containing 3 
               
               
                 205538_at 
                 4.549461 
                 down 
                 CORO2A 
                 coronin, actin binding protein, 2A 
               
               
                 210619_s_at 
                 4.5378346 
                 down 
                 HYAL1 
                 hyaluronoglucosaminidase 1 
               
               
                 204990_s_at 
                 4.5270753 
                 down 
                 ITGB4 
                 integrin, beta 4 
               
               
                 227204_at 
                 4.515133 
                 down 
                 PARD6G 
                 par-6 partitioning defective 6 homolog 
               
               
                   
                   
                   
                   
                 gamma ( C. elegans ) 
               
               
                 238063_at 
                 4.513157 
                 down 
                 TMEM154 
                 transmembrane protein 154 
               
               
                 219358_s_at 
                 4.5108666 
                 down 
                 ADAP2 
                 ArfGAP with dual PH domains 2 
               
               
                 206276_at 
                 4.498863 
                 down 
                 LY6D 
                 lymphocyte antigen 6 complex, locus D 
               
               
                 209792_s_at 
                 4.4899607 
                 down 
                 KLK10 
                 kallikrein-related peptidase 10 
               
               
                 208892_s_at 
                 4.489426 
                 down 
                 DUSP6 
                 dual specificity phosphatase 6 
               
               
                 206265_s_at 
                 4.488534 
                 down 
                 GPLD1 
                 glycosylphosphatidylinositol specific 
               
               
                   
                   
                   
                   
                 phospholipase D1 
               
               
                 235852_at 
                 4.484227 
                 down 
                 STON2 
                 CDNA FLJ37480 fis, clone 
               
               
                   
                   
                   
                   
                 BRAWH2013866, highly similar to 
               
               
                   
                   
                   
                   
                   Homo sapiens  stonin 2 mRNA 
               
               
                 221107_at 
                 4.484099 
                 down 
                 CHRNA9 
                 cholinergic receptor, nicotinic, alpha 9 
               
               
                 219691_at 
                 4.478258 
                 down 
                 SAMD9 
                 sterile alpha motif domain containing 9 
               
               
                 226499_at 
                 4.476055 
                 down 
                 NRARP 
                 MRNA full length insert cDNA clone 
               
               
                   
                   
                   
                   
                 EUROIMAGE 1499812 
               
               
                 227556_at 
                 4.4707904 
                 down 
                 NME7 
                 non-metastatic cells 7, protein 
               
               
                   
                   
                   
                   
                 expressed in (nucleoside-diphosphate 
               
               
                   
                   
                   
                   
                 kinase) 
               
               
                 1558846_at 
                 4.46551 
                 down 
                 PNLIPRP3 
                 pancreatic lipase-related protein 3 
               
               
                 215425_at 
                 4.46542 
                 down 
                 BTG3 
                 BTG family, member 3 
               
               
                 226226_at 
                 4.4539366 
                 down 
                 TMEM45B 
                 transmembrane protein 45B 
               
               
                 204204_at 
                 4.4521403 
                 down 
                 SLC31A2 
                 solute carrier family 31 (copper 
               
               
                   
                   
                   
                   
                 transporters), member 2 
               
               
                 208893_s_at 
                 4.4509206 
                 down 
                 DUSP6 
                 dual specificity phosphatase 6 
               
               
                 204029_at 
                 4.4487 
                 down 
                 CELSR2 
                 cadherin, EGF LAG seven-pass G-type 
               
               
                   
                   
                   
                   
                 receptor 2 (flamingo homolog, 
               
               
                   
                   
                   
                   
                   Drosophila ) 
               
               
                 201656_at 
                 4.4418707 
                 down 
                 ITGA6 
                 integrin, alpha 6 
               
               
                 206034_at 
                 4.426019 
                 down 
                 SERPINB8 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 8 
               
               
                 206391_at 
                 4.4257607 
                 down 
                 RARRES1 
                 retinoic acid receptor responder 
               
               
                   
                   
                   
                   
                 (tazarotene induced) 1 
               
               
                 228531_at 
                 4.4111724 
                 down 
                 SAMD9 
                 sterile alpha motif domain containing 9 
               
               
                 203638_s_at 
                 4.4092565 
                 down 
                 FGFR2 
                 fibroblast growth factor receptor 2 
               
               
                 206264_at 
                 4.4085407 
                 down 
                 GPLD1 
                 glycosylphosphatidylinositol specific 
               
               
                   
                   
                   
                   
                 phospholipase D1 
               
               
                 201015_s_at 
                 4.407748 
                 down 
                 JUP 
                 junction plakoglobin 
               
               
                 226029_at 
                 4.401417 
                 down 
                 VANGL2 
                 vang-like 2 (van gogh,  Drosophila ) 
               
               
                 202053_s_at 
                 4.3994246 
                 down 
                 ALDH3A2 
                 aldehyde dehydrogenase 3 family, 
               
               
                   
                   
                   
                   
                 member A2 
               
               
                 205675_at 
                 4.3889413 
                 down 
                 MTTP 
                 microsomal triglyceride transfer 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 203917_at 
                 4.3878665 
                 down 
                 CXADR 
                 coxsackie virus and adenovirus 
               
               
                   
                   
                   
                   
                 receptor 
               
               
                 1560250_s_at 
                 4.384614 
                 down 
                 LOC284242 
                 hypothetical protein LOC284242 
               
               
                 201242_s_at 
                 4.3839946 
                 down 
                 ATP1B1 
                 ATPase, Na+/K+ transporting, beta 1 
               
               
                   
                   
                   
                   
                 polypeptide 
               
               
                 203126_at 
                 4.3744597 
                 down 
                 IMPA2 
                 inositol(myo)-1(or 4)- 
               
               
                   
                   
                   
                   
                 monophosphatase 2 
               
               
                 219412_at 
                 4.3728795 
                 down 
                 RAB38 
                 RAB38, member RAS oncogene 
               
               
                   
                   
                   
                   
                 family 
               
               
                 220124_at 
                 4.371851 
                 down 
                 GAN 
                 gigaxonin 
               
               
                 211067_s_at 
                 4.3444204 
                 down 
                 GAS7 
                 growth arrest-specific 7 
               
               
                 220066_at 
                 4.3412647 
                 down 
                 NOD2 
                 nucleotide-binding oligomerization 
               
               
                   
                   
                   
                   
                 domain containing 2 
               
               
                 230188_at 
                 4.3192954 
                 down 
                 ICHTHYIN 
                 ichthyin protein 
               
               
                 202504_at 
                 4.3078084 
                 down 
                 TRIM29 
                 tripartite motif-containing 29 
               
               
                 1569144_a_at 
                 4.3075566 
                 down 
                 C9orf169 /// 
                 chromosome 9 open reading frame 169 
               
               
                   
                   
                   
                 LOC100130547 
                 /// hypothetical protein LOC100130547 
               
               
                 226733_at 
                 4.2923603 
                 down 
                 PFKFB2 
                 6-phosphofructo-2-kinase/fructose-2,6- 
               
               
                   
                   
                   
                   
                 biphosphatase 2 
               
               
                 222829_s_at 
                 4.292116 
                 down 
                 IL20RA 
                 interleukin 20 receptor, alpha 
               
               
                 229720_at 
                 4.2816586 
                 down 
                 BAG1 
                 BCL2-associated athanogene 
               
               
                 219395_at 
                 4.2743106 
                 down 
                 RBM35B 
                 RNA binding motif protein 35B 
               
               
                 208891_at 
                 4.2635026 
                 down 
                 DUSP6 
                 dual specificity phosphatase 6 
               
               
                 203585_at 
                 4.2597046 
                 down 
                 ZNF185 
                 zinc finger protein 185 (LIM domain) 
               
               
                 221690_s_at 
                 4.2536693 
                 down 
                 NLRP2 
                 NLR family, pyrin domain containing 2 
               
               
                 231270_at 
                 4.2472186 
                 down 
                 CA13 
                 carbonic anhydrase XIII 
               
               
                 244692_at 
                 4.2340446 
                 down 
                 CYP4F22 
                 cytochrome P450, family 4, subfamily 
               
               
                   
                   
                   
                   
                 F, polypeptide 22 
               
               
                 220413_at 
                 4.2331395 
                 down 
                 SLC39A2 
                 solute carrier family 39 (zinc 
               
               
                   
                   
                   
                   
                 transporter), member 2 
               
               
                 202289_s_at 
                 4.229875 
                 down 
                 TACC2 
                 transforming, acidic coiled-coil 
               
               
                   
                   
                   
                   
                 containing protein 2 
               
               
                 211362_s_at 
                 4.220602 
                 down 
                 SERPINB13 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 13 
               
               
                 203327_at 
                 4.2173615 
                 down 
                 IDE 
                 insulin-degrading enzyme 
               
               
                 1555173_at 
                 4.212528 
                 down 
                 STX19 
                 syntaxin 19 
               
               
                 213924_at 
                 4.212505 
                 down 
                 MPPE1 
                 MRNA; cDNA DKFZp686K2379 
               
               
                   
                   
                   
                   
                 (from clone DKFZp686K2379) 
               
               
                 204484_at 
                 4.199939 
                 down 
                 PIK3C2B 
                 phosphoinositide-3-kinase, class 2, 
               
               
                   
                   
                   
                   
                 beta polypeptide 
               
               
                 226907_at 
                 4.199478 
                 down 
                 PPP1R14C 
                 protein phosphatase 1, regulatory 
               
               
                   
                   
                   
                   
                 (inhibitor) subunit 14C 
               
               
                 205863_at 
                 4.1991963 
                 down 
                 S100A12 
                 S100 calcium binding protein A12 
               
               
                 222881_at 
                 4.1936674 
                 down 
                 HPSE 
                 heparanase 
               
               
                 201884_at 
                 4.1872177 
                 down 
                 CEACAM5 
                 carcinoembryonic antigen-related cell 
               
               
                   
                   
                   
                   
                 adhesion molecule 5 
               
               
                 228570_at 
                 4.181567 
                 down 
                 BTBD11 
                 BTB (POZ) domain containing 11 
               
               
                 210138_at 
                 4.179159 
                 down 
                 RGS20 
                 regulator of G-protein signaling 20 
               
               
                 228010_at 
                 4.178918 
                 down 
                 PPP2R2C 
                 protein phosphatase 2 (formerly 2A), 
               
               
                   
                   
                   
                   
                 regulatory subunit B, gamma isoform 
               
               
                 232181_at 
                 4.1646137 
                 down 
                 LOC153346 
                 hypothetical protein LOC153346 
               
               
                 41660_at 
                 4.1577396 
                 down 
                 CELSR1 
                 cadherin, EGF LAG seven-pass G-type 
               
               
                   
                   
                   
                   
                 receptor 1 (flamingo homolog, 
               
               
                   
                   
                   
                   
                   Drosophila ) 
               
               
                 227197_at 
                 4.152967 
                 down 
                 SGEF 
                 Src homology 3 domain-containing 
               
               
                   
                   
                   
                   
                 guanine nucleotide exchange factor 
               
               
                 225822_at 
                 4.1515694 
                 down 
                 TMEM125 
                 transmembrane protein 125 
               
               
                 219474_at 
                 4.142456 
                 down 
                 C3orf52 
                 chromosome 3 open reading frame 52 
               
               
                 205900_at 
                 4.1411896 
                 down 
                 KRT1 
                 keratin 1 
               
               
                 203367_at 
                 4.1374893 
                 down 
                 DUSP14 
                 dual specificity phosphatase 14 
               
               
                 225671_at 
                 4.136382 
                 down 
                 SPNS2 
                 spinster homolog 2 ( Drosophila ) 
               
               
                 55081_at 
                 4.132561 
                 down 
                 MICALL1 
                 MICAL-like 1 
               
               
                 223832_s_at 
                 4.123751 
                 down 
                 CAPNS2 
                 calpain, small subunit 2 
               
               
                 214490_at 
                 4.1185994 
                 down 
                 ARSF 
                 arylsulfatase F 
               
               
                 210372_s_at 
                 4.1101165 
                 down 
                 TPD52L1 
                 tumor protein D52-like 1 
               
               
                 209863_s_at 
                 4.1084065 
                 down 
                 TP63 
                 tumor protein p63 
               
               
                 210297_s_at 
                 4.1008377 
                 down 
                 MSMB 
                 microseminoprotein, beta- 
               
               
                 224210_s_at 
                 4.0987024 
                 down 
                 PXMP4 
                 peroxisomal membrane protein 4, 
               
               
                   
                   
                   
                   
                 24 kDa 
               
               
                 221245_s_at 
                 4.0908217 
                 down 
                 FZD5 
                 frizzled homolog 5 ( Drosophila ) 
               
               
                 205977_s_at 
                 4.087086 
                 down 
                 EPHA1 
                 EPH receptor A1 
               
               
                 230563_at 
                 4.0841923 
                 down 
                 RASGEF1A 
                 RasGEF domain family, member 1A 
               
               
                 226272_at 
                 4.0820107 
                 down 
                 RCAN3 
                 RCAN family member 3 
               
               
                 204004_at 
                 4.077613 
                 down 
                 PAWR 
                 PRKC, apoptosis, WT1, regulator 
               
               
                 205534_at 
                 4.076567 
                 down 
                 PCDH7 
                 protocadherin 7 
               
               
                 239272_at 
                 4.074428 
                 down 
                 MMP28 
                 matrix metallopeptidase 28 
               
               
                 204300_at 
                 4.0636954 
                 down 
                 PET112L 
                 PET112-like (yeast) 
               
               
                 235879_at 
                 4.043492 
                 down 
                 MBNL1 
                 MBNL protein 
               
               
                 1554179_s_at 
                 4.0318265 
                 down 
                 LYNX1 
                 Ly6/neurotoxin 1 
               
               
                 235272_at 
                 4.0244374 
                 down 
                 SBSN 
                 suprabasin 
               
               
                 235085_at 
                 4.018871 
                 down 
                 PRAGMIN 
                 homolog of rat pragma of Rnd2 
               
               
                 213954_at 
                 4.013676 
                 down 
                 FAM169A 
                 family with sequence similarity 169, 
               
               
                   
                   
                   
                   
                 member A 
               
               
                 226490_at 
                 4.012788 
                 down 
                 NHSL1 
                 NHS-like 1 
               
               
                 211002_s_at 
                 4.012248 
                 down 
                 TRIM29 
                 tripartite motif-containing 29 
               
               
                 212706_at 
                 3.9973824 
                 down 
                 LOC100132214 
                 similar to HSPC047 protein /// similar 
               
               
                   
                   
                   
                 /// 
                 to RAS p21 protein activator 4 /// 
               
               
                   
                   
                   
                 LOC100133005 
                 similar to HSPC047 protein /// RAS 
               
               
                   
                   
                   
                 /// 
                 p21 protein activator 4 
               
               
                   
                   
                   
                 LOC100134722 
               
               
                   
                   
                   
                 /// RASA4 
               
               
                 225354_s_at 
                 3.9922047 
                 down 
                 SH3BGRL2 
                 SH3 domain binding glutamic acid- 
               
               
                   
                   
                   
                   
                 rich protein like 2 
               
               
                 205190_at 
                 3.9871655 
                 down 
                 PLS1 
                 plastin 1 (I isoform) 
               
               
                 202054_s_at 
                 3.9822264 
                 down 
                 ALDH3A2 
                 aldehyde dehydrogenase 3 family, 
               
               
                   
                   
                   
                   
                 member A2 
               
               
                 232449_at 
                 3.9744756 
                 down 
                 BCO2 
                 beta-carotene oxygenase 2 
               
               
                 218342_s_at 
                 3.9690635 
                 down 
                 ERMP1 
                 endoplasmic reticulum 
               
               
                   
                   
                   
                   
                 metallopeptidase 1 
               
               
                 206043_s_at 
                 3.963122 
                 down 
                 ATP2C2 
                 ATPase, Ca++ transporting, type 2C, 
               
               
                   
                   
                   
                   
                 member 2 
               
               
                 206284_x_at 
                 3.962128 
                 down 
                 CLTB 
                 clathrin, light chain (Lcb) 
               
               
                 209126_x_at 
                 3.952012 
                 down 
                 KRT6B 
                 keratin 6B 
               
               
                 1553213_a_at 
                 3.9390984 
                 down 
                 KRT78 
                 keratin 78 
               
               
                 210413_x_at 
                 3.938409 
                 down 
                 SERPINB3 /// 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                 SERPINB4 
                 (ovalbumin), member 3 /// serpin 
               
               
                   
                   
                   
                   
                 peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 4 
               
               
                 223895_s_at 
                 3.9289596 
                 down 
                 EPN3 
                 epsin 3 
               
               
                 202546_at 
                 3.9224277 
                 down 
                 VAMP8 
                 vesicle-associated membrane protein 8 
               
               
                   
                   
                   
                   
                 (endobrevin) 
               
               
                 206453_s_at 
                 3.921748 
                 down 
                 NDRG2 
                 NDRG family member 2 
               
               
                 205020_s_at 
                 3.9133503 
                 down 
                 ARL4A 
                 ADP-ribosylation factor-like 4A 
               
               
                 213279_at 
                 3.907437 
                 down 
                 DHRS1 
                 dehydrogenase/reductase (SDR family) 
               
               
                   
                   
                   
                   
                 member 1 
               
               
                 214838_at 
                 3.9040148 
                 down 
                 SFT2D2 
                 SFT2 domain containing 2 
               
               
                 210102_at 
                 3.8968651 
                 down 
                 VWA5A 
                 von Willebrand factor A domain 
               
               
                   
                   
                   
                   
                 containing 5A 
               
               
                 225687_at 
                 3.8950646 
                 down 
                 FAM83D 
                 family with sequence similarity 83, 
               
               
                   
                   
                   
                   
                 member D 
               
               
                 1553695_a_at 
                 3.8867338 
                 down 
                 NLRX1 
                 NLR family member X1 
               
               
                 226064_s_at 
                 3.8825026 
                 down 
                 DGAT2 
                 diacylglycerol O-acyltransferase 
               
               
                   
                   
                   
                   
                 homolog 2 (mouse) 
               
               
                 205773_at 
                 3.8760667 
                 down 
                 CPEB3 
                 cytoplasmic polyadenylation element 
               
               
                   
                   
                   
                   
                 binding protein 3 
               
               
                 223232_s_at 
                 3.8725953 
                 down 
                 CGN 
                 cingulin 
               
               
                 209570_s_at 
                 3.870752 
                 down 
                 D4S234E 
                 DNA segment on chromosome 4 
               
               
                   
                   
                   
                   
                 (unique) 234 expressed sequence 
               
               
                 224806_at 
                 3.8689046 
                 down 
                 TRIM25 
                 tripartite motif-containing 25 
               
               
                 1554648_a_at 
                 3.8646846 
                 down 
                 DUOXA1 
                 dual oxidase maturation factor 1 
               
               
                 213501_at 
                 3.8544102 
                 down 
                 ACOX1 
                 acyl-Coenzyme A oxidase 1, palmitoyl 
               
               
                 220786 s_at 
                 3.844398 
                 down 
                 SLC38A4 
                 solute carrier family 38, member 4 
               
               
                 216060_s_at 
                 3.8402324 
                 down 
                 DAAM1 
                 dishevelled associated activator of 
               
               
                   
                   
                   
                   
                 morphogenesis 1 
               
               
                 224435_at 
                 3.8286057 
                 down 
                 C10orf57 /// 
                 chromosome 10 open reading frame 57 
               
               
                   
                   
                   
                 C10orf58 
                 /// chromosome 10 open reading frame 
               
               
                   
                   
                   
                   
                 58 
               
               
                 202489_s_at 
                 3.826976 
                 down 
                 FXYD3 
                 FXYD domain containing ion transport 
               
               
                   
                   
                   
                   
                 regulator 3 
               
               
                 228124_at 
                 3.8211079 
                 down 
                 ABHD12 
                 abhydrolase domain containing 12 
               
               
                 223748_at 
                 3.8204598 
                 down 
                 SLC4A11 
                 solute carrier family 4, sodium borate 
               
               
                   
                   
                   
                   
                 transporter, member 11 
               
               
                 225301_s_at 
                 3.8147264 
                 down 
                 MYO5B 
                 myosin VB 
               
               
                 205030_at 
                 3.803794 
                 down 
                 FABP7 
                 fatty acid binding protein 7, brain 
               
               
                 203997_at 
                 3.7991052 
                 down 
                 PTPN3 
                 protein tyrosine phosphatase, non- 
               
               
                   
                   
                   
                   
                 receptor type 3 
               
               
                 206409_at 
                 3.792147 
                 down 
                 TIAM1 
                 T-cell lymphoma invasion and 
               
               
                   
                   
                   
                   
                 metastasis 1 
               
               
                 230464_at 
                 3.7890499 
                 down 
                 S1PR5 
                 sphingosine-1-phosphate receptor 5 
               
               
                 217080_s_at 
                 3.788767 
                 down 
                 HOMER2 
                 homer homolog 2 ( Drosophila ) 
               
               
                 228596_at 
                 3.7859466 
                 down 
                 LOC728377 
                 similar to rho guanine nucleotide 
               
               
                   
                   
                   
                   
                 exchange factor 5 
               
               
                 219121_s_at 
                 3.7856553 
                 down 
                 RBM35A 
                 RNA binding motif protein 35A 
               
               
                 206605_at 
                 3.7852893 
                 down 
                 P11 
                 26 serine protease 
               
               
                 218796_at 
                 3.7840903 
                 down 
                 FERMT1 
                 fermitin family homolog 1 
               
               
                   
                   
                   
                   
                 ( Drosophila ) 
               
               
                 206004_at 
                 3.7830596 
                 down 
                 TGM3 
                 transglutaminase 3 (E polypeptide, 
               
               
                   
                   
                   
                   
                 protein-glutamine-gamma- 
               
               
                   
                   
                   
                   
                 glutamyltransferase) 
               
               
                 204519_s_at 
                 3.7812307 
                 down 
                 PLLP 
                 plasma membrane proteolipid 
               
               
                   
                   
                   
                   
                 (plasmolipin) 
               
               
                 203128_at 
                 3.7796383 
                 down 
                 SPTLC2 
                 serine palmitoyltransferase, long chain 
               
               
                   
                   
                   
                   
                 base subunit 2 
               
               
                 231875_at 
                 3.7795398 
                 down 
                 KIF21A 
                 kinesin family member 21A 
               
               
                 212096_s_at 
                 3.7734342 
                 down 
                 MTUS1 
                 mitochondrial tumor suppressor 1 
               
               
                 226003_at 
                 3.7700498 
                 down 
                 KIF21A 
                 kinesin family member 21A 
               
               
                 200832_s_at 
                 3.7699654 
                 down 
                 SCD 
                 stearoyl-CoA desaturase (delta-9- 
               
               
                   
                   
                   
                   
                 desaturase) 
               
               
                 208614_s_at 
                 3.7652352 
                 down 
                 FLNB 
                 filamin B, beta (actin binding protein 
               
               
                   
                   
                   
                   
                 278) 
               
               
                 35820_at 
                 3.763104 
                 down 
                 GM2A 
                 GM2 ganglioside activator 
               
               
                 235048_at 
                 3.7585585 
                 down 
                 FAM169A 
                 family with sequence similarity 169, 
               
               
                   
                   
                   
                   
                 member A 
               
               
                 202540_s_at 
                 3.7533727 
                 down 
                 HMGCR 
                 3-hydroxy-3-methylglutaryl-Coenzyme 
               
               
                   
                   
                   
                   
                 A reductase 
               
               
                 210375_at 
                 3.7446036 
                 down 
                 PTGER3 
                 prostaglandin E receptor 3 (subtype 
               
               
                   
                   
                   
                   
                 EP3) 
               
               
                 219010_at 
                 3.7444217 
                 down 
                 C1orf106 
                 chromosome 1 open reading frame 106 
               
               
                 226129_at 
                 3.7394128 
                 down 
                 FAM83H 
                 family with sequence similarity 83, 
               
               
                   
                   
                   
                   
                 member H 
               
               
                 232151_at 
                 3.7381117 
                 down 
                 MACC1 
                 metastasis associated in colon cancer 1 
               
               
                 236313_at 
                 3.736902 
                 down 
                 CDKN2B 
                 cyclin-dependent kinase inhibitor 2B 
               
               
                   
                   
                   
                   
                 (p15, inhibits CDK4) 
               
               
                 227962_at 
                 3.7365305 
                 down 
                 ACOX1 
                 acyl-Coenzyme A oxidase 1, palmitoyl 
               
               
                 235626_at 
                 3.7264879 
                 down 
                 CAMK1D 
                 calcium/calmodulin-dependent protein 
               
               
                   
                   
                   
                   
                 kinase ID 
               
               
                 1559190_s_at 
                 3.7257981 
                 down 
                 RDH13 
                 CDNA PSEC0082 fis, clone 
               
               
                   
                   
                   
                   
                 NT2RP2004966, highly similar to 
               
               
                   
                   
                   
                   
                 Retinol dehydrogenase 13 (EC 1.1.1.—) 
               
               
                 227735_s_at 
                 3.7186708 
                 down 
                 C10orf99 
                 chromosome 10 open reading frame 99 
               
               
                 227109_at 
                 3.7156994 
                 down 
                 CYP2R1 
                 cytochrome P450, family 2, subfamily 
               
               
                   
                   
                   
                   
                 R, polypeptide 1 
               
               
                 242773_at 
                 3.714043 
                 down 
                 SLC5A1 
                 solute carrier family 5 (sodium/glucose 
               
               
                   
                   
                   
                   
                 cotransporter), member 1 
               
               
                 223541_at 
                 3.713034 
                 down 
                 HAS3 
                 hyaluronan synthase 3 
               
               
                 1553057_at 
                 3.7106702 
                 down 
                 SERPINB12 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 12 
               
               
                 214279_s_at 
                 3.7052615 
                 down 
                 NDRG2 
                 NDRG family member 2 
               
               
                 221566_s_at 
                 3.7041054 
                 down 
                 NOL3 
                 nucleolar protein 3 (apoptosis repressor 
               
               
                   
                   
                   
                   
                 with CARD domain) 
               
               
                 219496_at 
                 3.6988554 
                 down 
                 ANKRD57 
                 ankyrin repeat domain 57 
               
               
                 225806_at 
                 3.6983435 
                 down 
                 JUB 
                 jub, ajuba homolog ( Xenopus laevis ) 
               
               
                 204765_at 
                 3.6892798 
                 down 
                 ARHGEF5 
                 Rho guanine nucleotide exchange 
               
               
                   
                   
                   
                   
                 factor (GEF) 5 
               
               
                 207430 s_at 
                 3.6888688 
                 down 
                 MSMB 
                 microseminoprotein, beta- 
               
               
                 226382_at 
                 3.6853971 
                 down 
                 LOC283070 
                 hypothetical protein LOC283070 
               
               
                 201693_s_at 
                 3.6807284 
                 down 
                 EGR1 
                 early growth response 1 
               
               
                 206277_at 
                 3.679081 
                 down 
                 P2RY2 
                 purinergic receptor P2Y, G-protein 
               
               
                   
                   
                   
                   
                 coupled, 2 
               
               
                 219821_s_at 
                 3.6787474 
                 down 
                 GFOD1 
                 glucose-fructose oxidoreductase 
               
               
                   
                   
                   
                   
                 domain containing 1 
               
               
                 212737_at 
                 3.6714 
                 down 
                 GM2A 
                 GM2 ganglioside activator 
               
               
                 209719_x_at 
                 3.6645396 
                 down 
                 SERPINB3 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 3 
               
               
                 205172_x_at 
                 3.6626048 
                 down 
                 CLTB 
                 clathrin, light chain (Lcb) 
               
               
                 1553764_a_at 
                 3.662437 
                 down 
                 JUB 
                 jub, ajuba homolog ( Xenopus laevis ) 
               
               
                 204351_at 
                 3.6600852 
                 down 
                 S100P 
                 S100 calcium binding protein P 
               
               
                 203148_s_at 
                 3.6579587 
                 down 
                 TRIM14 
                 tripartite motif-containing 14 
               
               
                 209000_s_at 
                 3.6571388 
                 down 
                 40064 
                 septin 8 
               
               
                 205786_s_at 
                 3.6454937 
                 down 
                 ITGAM 
                 integrin, alpha M (complement 
               
               
                   
                   
                   
                   
                 component 3 receptor 3 subunit) 
               
               
                 223298_s_at 
                 3.6409454 
                 down 
                 NT5C3 
                 5′-nucleotidase, cytosolic III 
               
               
                 1568868_at 
                 3.6400533 
                 down 
                 CYP27C1 
                 cytochrome P450, family 27, 
               
               
                   
                   
                   
                   
                 subfamily C, polypeptide 1 
               
               
                 210544_s_at 
                 3.6329489 
                 down 
                 ALDH3A2 
                 aldehyde dehydrogenase 3 family, 
               
               
                   
                   
                   
                   
                 member A2 
               
               
                 212314_at 
                 3.628236 
                 down 
                 KIAA0746 /// 
                 KIAA0746 protein /// serine 
               
               
                   
                   
                   
                 SERINC2 
                 incorporator 2 
               
               
                 206421_s_at 
                 3.622729 
                 down 
                 SERPINB7 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 7 
               
               
                 202539_s_at 
                 3.6214926 
                 down 
                 HMGCR 
                 3-hydroxy-3-methylglutaryl-Coenzyme 
               
               
                   
                   
                   
                   
                 A reductase 
               
               
                 1553211_at 
                 3.6197479 
                 down 
                 ANKFN1 
                 ankyrin-repeat and fibronectin type III 
               
               
                   
                   
                   
                   
                 domain containing 1 
               
               
                 202761_s_at 
                 3.6197405 
                 down 
                 SYNE2 
                 spectrin repeat containing, nuclear 
               
               
                   
                   
                   
                   
                 envelope 2 
               
               
                 205783_at 
                 3.6192052 
                 down 
                 KLK13 
                 kallikrein-related peptidase 13 
               
               
                 225502_at 
                 3.607785 
                 down 
                 DOCK8 
                 dedicator of cytokinesis 8 
               
               
                 216905_s_at 
                 3.6036117 
                 down 
                 ST14 
                 suppression of tumorigenicity 14 
               
               
                   
                   
                   
                   
                 (colon carcinoma) 
               
               
                 221779_at 
                 3.6017182 
                 down 
                 MICALL1 
                 MICAL-like 1 
               
               
                 204734_at 
                 3.6002238 
                 down 
                 KRT15 
                 keratin 15 
               
               
                 231732_at 
                 3.594498 
                 down 
                 SMPD3 
                 sphingomyelin phosphodiesterase 3, 
               
               
                   
                   
                   
                   
                 neutral membrane (neutral 
               
               
                   
                   
                   
                   
                 sphingomyelinase II) 
               
               
                 220030_at 
                 3.5835576 
                 down 
                 STYK1 
                 serine/threonine/tyrosine kinase 1 
               
               
                 39248_at 
                 3.5794623 
                 down 
                 AQP3 
                 aquaporin 3 (Gill blood group) 
               
               
                 222876_s_at 
                 3.5791473 
                 down 
                 ADAP2 
                 ArfGAP with dual PH domains 2 
               
               
                 204636_at 
                 3.5764592 
                 down 
                 COL17A1 
                 collagen, type XVII, alpha 1 
               
               
                 210553_x_at 
                 3.5725062 
                 down 
                 PCSK6 
                 proprotein convertase subtilisin/kexin 
               
               
                   
                   
                   
                   
                 type 6 
               
               
                 225864_at 
                 3.5664208 
                 down 
                 FAM84B 
                 family with sequence similarity 84, 
               
               
                   
                   
                   
                   
                 member B 
               
               
                 209211_at 
                 3.5630605 
                 down 
                 KLF5 
                 Kruppel-like factor 5 (intestinal) 
               
               
                 1552777_a_at 
                 3.5581756 
                 down 
                 RAET1E 
                 retinoic acid early transcript 1E 
               
               
                 239547_at 
                 3.5570898 
                 down 
                 HS3ST6 
                 heparan sulfate (glucosamine) 3-O- 
               
               
                   
                   
                   
                   
                 sulfotransferase 6 
               
               
                 224839_s_at 
                 3.5547016 
                 down 
                 GPT2 
                 glutamic pyruvate transaminase 
               
               
                   
                   
                   
                   
                 (alanine aminotransferase) 2 
               
               
                 1553364_at 
                 3.5530663 
                 down 
                 PNPLA1 
                 patatin-like phospholipase domain 
               
               
                   
                   
                   
                   
                 containing 1 
               
               
                 235117_at 
                 3.5501385 
                 down 
                 CHAC2 
                 ChaC, cation transport regulator 
               
               
                   
                   
                   
                   
                 homolog 2 ( E. coli ) 
               
               
                 222354_at 
                 3.5409195 
                 down 
                 F11R 
                 F11 receptor 
               
               
                 219976_at 
                 3.54039 
                 down 
                 HOOK1 
                 hook homolog 1 ( Drosophila ) 
               
               
                 211372_s_at 
                 3.5362017 
                 down 
                 IL1R2 
                 interleukin 1 receptor, type II 
               
               
                 219316_s_at 
                 3.5322564 
                 down 
                 FLVCR2 
                 feline leukemia virus subgroup C 
               
               
                   
                   
                   
                   
                 cellular receptor family, member 2 
               
               
                 224646_x_at 
                 3.5317452 
                 down 
                 H19 
                 H19, imprinted maternally expressed 
               
               
                   
                   
                   
                   
                 transcript (non-protein coding) 
               
               
                 65438_at 
                 3.5268037 
                 down 
                 KIAA1609 
                 KIAA1609 
               
               
                 226666_at 
                 3.5185058 
                 down 
                 DAAM1 
                 dishevelled associated activator of 
               
               
                   
                   
                   
                   
                 morphogenesis 1 
               
               
                 219597_s_at 
                 3.5163934 
                 down 
                 DUOX1 
                 dual oxidase 1 
               
               
                 205421_at 
                 3.5158527 
                 down 
                 SLC22A3 
                 solute carrier family 22 (extraneuronal 
               
               
                   
                   
                   
                   
                 monoamine transporter), member 3 
               
               
                 206714_at 
                 3.5117545 
                 down 
                 ALOX15B 
                 arachidonate 15-lipoxygenase, type B 
               
               
                 219752_at 
                 3.5069795 
                 down 
                 RASAL1 
                 RAS protein activator like 1 (GAP1 
               
               
                   
                   
                   
                   
                 like) 
               
               
                 203256_at 
                 3.5057578 
                 down 
                 CDH3 
                 cadherin 3, type 1, P-cadherin 
               
               
                   
                   
                   
                   
                 (placental) 
               
               
                 207558_s_at 
                 3.5035906 
                 down 
                 PITX2 
                 paired-like homeodomain 2 
               
               
                 231969_at 
                 3.4996755 
                 down 
                 STOX2 
                 storkhead box 2 
               
               
                 205249_at 
                 3.4971406 
                 down 
                 EGR2 
                 early growth response 2 (Krox-20 
               
               
                   
                   
                   
                   
                 homolog,  Drosophila ) 
               
               
                 1563900_at 
                 3.4969769 
                 down 
                 FAM83B 
                 family with sequence similarity 83, 
               
               
                   
                   
                   
                   
                 member B 
               
               
                 210026_s_at 
                 3.474502 
                 down 
                 CARD10 
                 caspase recruitment domain family, 
               
               
                   
                   
                   
                   
                 member 10 
               
               
                 225095_at 
                 3.4744895 
                 down 
                 SPTLC2 
                 KIAA0526 protein 
               
               
                 1553333_at 
                 3.474137 
                 down 
                 C1orf161 
                 chromosome 1 open reading frame 161 
               
               
                 239710_at 
                 3.4720347 
                 down 
                 FIGN 
                 fidgetin 
               
               
                 203780_at 
                 3.4676228 
                 down 
                 MPZL2 
                 myelin protein zero-like 2 
               
               
                 221843_s_at 
                 3.4610984 
                 down 
                 KIAA1609 
                 KIAA1609 
               
               
                 208191_x_at 
                 3.4576283 
                 down 
                 PSG4 
                 pregnancy specific beta-1-glycoprotein 4 
               
               
                 201428_at 
                 3.4539902 
                 down 
                 CLDN4 
                 claudin 4 
               
               
                 229296_at 
                 3.4521377 
                 down 
                 LOC100128501 
                 hypothetical protein LOC100128501 
               
               
                 211043_s_at 
                 3.446346 
                 down 
                 CLTB 
                 clathrin, light chain (Lcb) 
               
               
                 218432_at 
                 3.4458005 
                 down 
                 FBXO3 
                 F-box protein 3 
               
               
                 201005_at 
                 3.4436064 
                 down 
                 CD9 
                 CD9 molecule 
               
               
                 210868_s_at 
                 3.4410589 
                 down 
                 ELOVL6 
                 ELOVL family member 6, elongation 
               
               
                   
                   
                   
                   
                 of long chain fatty acids (FEN1/Elo2, 
               
               
                   
                   
                   
                   
                 SUR4/Elo3-like, yeast) 
               
               
                 227276_at 
                 3.4398205 
                 down 
                 PLXDC2 
                 plexin domain containing 2 
               
               
                 213820_s_at 
                 3.4357908 
                 down 
                 STARD5 
                 StAR-related lipid transfer (START) 
               
               
                   
                   
                   
                   
                 domain containing 5 
               
               
                 209301_at 
                 3.4329016 
                 down 
                 CA2 
                 carbonic anhydrase II 
               
               
                 204941_s_at 
                 3.4287107 
                 down 
                 ALDH3B2 
                 aldehyde dehydrogenase 3 family, 
               
               
                   
                   
                   
                   
                 member B2 
               
               
                 223199_at 
                 3.4269447 
                 down 
                 MKNK2 
                 MAP kinase interacting 
               
               
                   
                   
                   
                   
                 serine/threonine kinase 2 
               
               
                 224327_s_at 
                 3.4269319 
                 down 
                 DGAT2 
                 diacylglycerol O-acyltransferase 
               
               
                   
                   
                   
                   
                 homolog 2 (mouse) 
               
               
                 235678_at 
                 3.4267802 
                 down 
                 GM2A 
                 GM2 ganglioside activator 
               
               
                 236225_at 
                 3.426428 
                 down 
                 GGT6 
                 gamma-glutamyltransferase 6 
               
               
                 221567_at 
                 3.4161565 
                 down 
                 NOL3 
                 nucleolar protein 3 (apoptosis repressor 
               
               
                   
                   
                   
                   
                 with CARD domain) 
               
               
                 204546_at 
                 3.4134994 
                 down 
                 KIAA0513 
                 KIAA0513 
               
               
                 204058_at 
                 3.4133024 
                 down 
                 ME1 
                 malic enzyme 1, NADP(+)-dependent, 
               
               
                   
                   
                   
                   
                 cytosolic 
               
               
                 210065_s_at 
                 3.4122272 
                 down 
                 UPK1B 
                 uroplakin 1B 
               
               
                 1557165_s_at 
                 3.4083939 
                 down 
                 KLHL18 
                 kelch-like 18 ( Drosophila ) 
               
               
                 205014_at 
                 3.40602 
                 down 
                 FGFBP1 
                 fibroblast growth factor binding 
               
               
                   
                   
                   
                   
                 protein 1 
               
               
                 221669_s_at 
                 3.4037082 
                 down 
                 ACAD8 
                 acyl-Coenzyme A dehydrogenase 
               
               
                   
                   
                   
                   
                 family, member 8 
               
               
                 225525_at 
                 3.4010828 
                 down 
                 CTA- 
                 KIAA1671 protein /// hypothetical 
               
               
                   
                   
                   
                 221G9.4 /// 
                 protein LOC100131004 
               
               
                   
                   
                   
                 LOC100131004 
               
               
                 231118_at 
                 3.3923123 
                 down 
                 ANKRD35 
                 ankyrin repeat domain 35 
               
               
                 229337_at 
                 3.3913348 
                 down 
                 USP2 
                 ubiquitin specific peptidase 2 
               
               
                 219670_at 
                 3.3814268 
                 down 
                 BEND5 
                 BEN domain containing 5 
               
               
                 205048_s_at 
                 3.3812659 
                 down 
                 PSPH 
                 phosphoserine phosphatase 
               
               
                 1554062_at 
                 3.3779898 
                 down 
                 XG 
                 Xg blood group 
               
               
                 222866_s_at 
                 3.372543 
                 down 
                 FLVCR2 
                 feline leukemia virus subgroup C 
               
               
                   
                   
                   
                   
                 cellular receptor family, member 2 
               
               
                 219429_at 
                 3.369738 
                 down 
                 FA2H 
                 fatty acid 2-hydroxylase 
               
               
                 232500_at 
                 3.36646 
                 down 
                 C20orf74 
                 chromosome 20 open reading frame 74 
               
               
                 209600_s_at 
                 3.3606262 
                 down 
                 ACOX1 
                 acyl-Coenzyme A oxidase 1, palmitoyl 
               
               
                 236213_at 
                 3.3596435 
                 down 
                 LOC100130885 
                 hypothetical protein LOC100130885 
               
               
                 225536_at 
                 3.354181 
                 down 
                 TMEM54 
                 transmembrane protein 54 
               
               
                 201534_s_at 
                 3.353898 
                 down 
                 UBL3 
                 ubiquitin-like 3 
               
               
                 228729_at 
                 3.349102 
                 down 
                 CCNB1 
                 cyclin B1 
               
               
                 223839_s_at 
                 3.3401856 
                 down 
                 SCD /// 
                 stearoyl-CoA desaturase (delta-9- 
               
               
                   
                   
                   
                 SCDOS 
                 desaturase) /// stearoyl-CoA desaturase 
               
               
                   
                   
                   
                   
                 opposite strand 
               
               
                 243611_at 
                 3.3352149 
                 down 
                 MICALCL 
                 MICAL C-terminal like 
               
               
                 211382_s_at 
                 3.335143 
                 down 
                 TACC2 
                 transforming, acidic coiled-coil 
               
               
                   
                   
                   
                   
                 containing protein 2 
               
               
                 220149_at 
                 3.3329418 
                 down 
                 C2orf54 
                 chromosome 2 open reading frame 54 
               
               
                 227856_at 
                 3.3276808 
                 down 
                 C4orf32 
                 chromosome 4 open reading frame 32 
               
               
                 228469_at 
                 3.3271294 
                 down 
                 PPID 
                 Cyclophilin-40 
               
               
                 230518_at 
                 3.3258517 
                 down 
                 MPZL2 
                 myelin protein zero-like 2 
               
               
                 209558_s_at 
                 3.322049 
                 down 
                 HIP1R 
                 huntingtin interacting protein 1 related 
               
               
                 227015_at 
                 3.3209336 
                 down 
                 ASPHD2 
                 aspartate beta-hydroxylase domain 
               
               
                   
                   
                   
                   
                 containing 2 
               
               
                 201287_s_at 
                 3.32023 
                 down 
                 SDC1 
                 syndecan 1 
               
               
                 205470_s_at 
                 3.3177328 
                 down 
                 KLK11 
                 kallikrein-related peptidase 11 
               
               
                 209569_x_at 
                 3.3130386 
                 down 
                 D4S234E 
                 DNA segment on chromosome 4 
               
               
                   
                   
                   
                   
                 (unique) 234 expressed sequence 
               
               
                 228640_at 
                 3.3072002 
                 down 
                 PCDH7 
                 protocadherin 7 
               
               
                 225001_at 
                 3.305868 
                 down 
                 RAB3D 
                 RAB3D, member RAS oncogene 
               
               
                   
                   
                   
                   
                 family 
               
               
                 232082_x_at 
                 3.3027992 
                 down 
                 SPRR3 
                 small proline-rich protein 3 
               
               
                 223694_at 
                 3.3023326 
                 down 
                 TRIM7 
                 tripartite motif-containing 7 
               
               
                 215393_s_at 
                 3.3011584 
                 down 
                 COBLL1 
                 COBL-like 1 
               
               
                 229114_at 
                 3.3010995 
                 down 
                 GAB1 
                 GRB2-associated binding protein 1 
               
               
                 235405_at 
                 3.2997503 
                 down 
                 GSTA4 
                 glutathione S-transferase alpha 4 
               
               
                 232090_at 
                 3.2993267 
                 down 
                 LOC100128178 
                 similar to hCG2041313 
               
               
                 228256_s_at 
                 3.2980163 
                 down 
                 EPB41L4A 
                 erythrocyte membrane protein band 4.1 
               
               
                   
                   
                   
                   
                 like 4A 
               
               
                 227134_at 
                 3.2938037 
                 down 
                 SYTL1 
                 synaptotagmin-like 1 
               
               
                 218150_at 
                 3.2934453 
                 down 
                 ARL5A 
                 ADP-ribosylation factor-like 5A 
               
               
                 205403_at 
                 3.2927191 
                 down 
                 IL1R2 
                 interleukin 1 receptor, type II 
               
               
                 231771_at 
                 3.2887797 
                 down 
                 GJB6 
                 gap junction protein, beta 6, 30 kDa 
               
               
                 227782_at 
                 3.2884097 
                 down 
                 ZBTB7C 
                 zinc finger and BTB domain 
               
               
                   
                   
                   
                   
                 containing 7C 
               
               
                 227461_at 
                 3.287732 
                 down 
                 STON2 
                 stonin 2 
               
               
                 203509_at 
                 3.2846527 
                 down 
                 SORL1 
                 sortilin-related receptor, L(DLR class) 
               
               
                   
                   
                   
                   
                 A repeats-containing 
               
               
                 223168_at 
                 3.2830467 
                 down 
                 RHOU 
                 ras homolog gene family, member U 
               
               
                 209631_s_at 
                 3.2649126 
                 down 
                 GPR37 
                 G protein-coupled receptor 37 
               
               
                   
                   
                   
                   
                 (endothelin receptor type B-like) 
               
               
                 205029_s_at 
                 3.2629297 
                 down 
                 FABP7 
                 fatty acid binding protein 7, brain 
               
               
                 226649_at 
                 3.2610345 
                 down 
                 PANK1 
                 pantothenate kinase 1 
               
               
                 227889_at 
                 3.25648 
                 down 
                 LPCAT2 
                 lysophosphatidylcholine 
               
               
                   
                   
                   
                   
                 acyltransferase 2 
               
               
                 213094_at 
                 3.2563322 
                 down 
                 GPR126 
                 G protein-coupled receptor 126 
               
               
                 244261_at 
                 3.2521746 
                 down 
                 IL28RA 
                 interleukin 28 receptor, alpha 
               
               
                   
                   
                   
                   
                 (interferon, lambda receptor) 
               
               
                 201340_s_at 
                 3.2456722 
                 down 
                 ENC1 
                 ectodermal-neural cortex (with BTB- 
               
               
                   
                   
                   
                   
                 like domain) 
               
               
                 217974_at 
                 3.2413647 
                 down 
                 TM7SF3 
                 transmembrane 7 superfamily member 3 
               
               
                 223631_s_at 
                 3.2411804 
                 down 
                 C19orf33 
                 chromosome 19 open reading frame 33 
               
               
                 230765_at 
                 3.2385905 
                 down 
                 KIAA1239 
                 KIAA1239 
               
               
                 1552566_at 
                 3.2320094 
                 down 
                 BTBD16 
                 BTB (POZ) domain containing 16 
               
               
                 225613_at 
                 3.2306297 
                 down 
                 LOC100128443 
                 hypothetical protein LOC100128443 /// 
               
               
                   
                   
                   
                 /// MAST4 
                 microtubule associated 
               
               
                   
                   
                   
                   
                 serine/threonine kinase family member 4 
               
               
                 205776_at 
                 3.222692 
                 down 
                 FMO5 
                 flavin containing monooxygenase 5 
               
               
                 203007_x_at 
                 3.2214603 
                 down 
                 LYPLA1 
                 lysophospholipase I 
               
               
                 229103_at 
                 3.2176034 
                 down 
                 WNT3 
                 wingless-type MMTV integration site 
               
               
                   
                   
                   
                   
                 family, member 3 
               
               
                 224367_at 
                 3.2115495 
                 down 
                 BEX2 
                 brain expressed X-linked 2 
               
               
                 225834_at 
                 3.2113602 
                 down 
                 FAM72A /// 
                 family with sequence similarity 72, 
               
               
                   
                   
                   
                 FAM72B /// 
                 member A /// family with sequence 
               
               
                   
                   
                   
                 GCUD2 
                 similarity 72, member B /// gastric 
               
               
                   
                   
                   
                   
                 cancer up-regulated-2 
               
               
                 230266_at 
                 3.2071729 
                 down 
                 RAB7B 
                 RAB7B, member RAS oncogene 
               
               
                   
                   
                   
                   
                 family 
               
               
                 206059_at 
                 3.2045915 
                 down 
                 ZNF91 
                 zinc finger protein 91 
               
               
                 225807_at 
                 3.1980147 
                 down 
                 JUB 
                 jub, ajuba homolog ( Xenopus laevis ) 
               
               
                 203786_s_at 
                 3.196283 
                 down 
                 TPD52L1 
                 tumor protein D52-like 1 
               
               
                 1554895_a_at 
                 3.1930003 
                 down 
                 RHBDL2 
                 rhomboid, veinlet-like 2 ( Drosophila ) 
               
               
                 203665_at 
                 3.1928537 
                 down 
                 HMOX1 
                 heme oxygenase (decycling) 1 
               
               
                 204363_at 
                 3.1915643 
                 down 
                 F3 
                 coagulation factor III (thromboplastin, 
               
               
                   
                   
                   
                   
                 tissue factor) 
               
               
                 238164_at 
                 3.190472 
                 down 
                 USP6NL 
                 USP6 N-terminal like 
               
               
                 212322_at 
                 3.1838899 
                 down 
                 SGPL1 
                 sphingosine-1-phosphate lyase 1 
               
               
                 1566766_a_at 
                 3.1814005 
                 down 
                 MACC1 
                 metastasis associated in colon cancer 1 
               
               
                 207126_x_at 
                 3.1803102 
                 down 
                 UGT1A1 /// 
                 UDP glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A10 /// 
                 polypeptide A1 /// UDP 
               
               
                   
                   
                   
                 UGT1A4 /// 
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A6 /// 
                 polypeptide A10 /// UDP 
               
               
                   
                   
                   
                 UGT1A8 /// 
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A9 
                 polypeptide A4 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A6 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A8 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A9 
               
               
                 222223_s_at 
                 3.176874 
                 down 
                 IL1F5 
                 interleukin 1 family, member 5 (delta) 
               
               
                 239694_at 
                 3.174275 
                 down 
                 TRIM7 
                 tripartite motif-containing 7 
               
               
                 206969_at 
                 3.1713967 
                 down 
                 KRT34 
                 keratin 34 
               
               
                 207540_s_at 
                 3.1631026 
                 down 
                 SYK 
                 spleen tyrosine kinase 
               
               
                 235857_at 
                 3.157146 
                 down 
                 KCTD11 
                 potassium channel tetramerisation 
               
               
                   
                   
                   
                   
                 domain containing 11 
               
               
                 205829_at 
                 3.1498919 
                 down 
                 HSD17B1 
                 hydroxysteroid (17-beta) 
               
               
                   
                   
                   
                   
                 dehydrogenase 1 
               
               
                 209720_s_at 
                 3.1471493 
                 down 
                 SERPINB3 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 3 
               
               
                 226698_at 
                 3.1410942 
                 down 
                 FCHSD1 
                 FCH and double SH3 domains 1 
               
               
                 203147_s_at 
                 3.140271 
                 down 
                 TRIM14 
                 tripartite motif-containing 14 
               
               
                 214036_at 
                 3.1385825 
                 down 
                 EFNA5 
                 ephrin-A5 
               
               
                 1558378_a_at 
                 3.1375017 
                 down 
                 AHNAK2 
                 AHNAK nucleoprotein 2 
               
               
                 203887_s_at 
                 3.1370428 
                 down 
                 THBD 
                 thrombomodulin 
               
               
                 205015_s_at 
                 3.1335502 
                 down 
                 TGFA 
                 transforming growth factor, alpha 
               
               
                 218756_s_at 
                 3.1297085 
                 down 
                 DHRS11 
                 dehydrogenase/reductase (SDR family) 
               
               
                   
                   
                   
                   
                 member 11 
               
               
                 204256_at 
                 3.1214519 
                 down 
                 ELOVL6 
                 ELOVL family member 6, elongation 
               
               
                   
                   
                   
                   
                 of long chain fatty acids (FEN1/Elo2, 
               
               
                   
                   
                   
                   
                 SUR4/Elo3-like, yeast) 
               
               
                 206912_at 
                 3.120563 
                 down 
                 FOXE1 
                 forkhead box E1 (thyroid transcription 
               
               
                   
                   
                   
                   
                 factor 2) 
               
               
                 209885_at 
                 3.1201258 
                 down 
                 RHOD 
                 ras homolog gene family, member D 
               
               
                 229638_at 
                 3.1183026 
                 down 
                 IRX3 
                 iroquois homeobox 3 
               
               
                 220249_at 
                 3.116939 
                 down 
                 HYAL4 
                 hyaluronoglucosaminidase 4 
               
               
                 210347_s_at 
                 3.1119802 
                 down 
                 BCL11A 
                 B-cell CLL/lymphoma 11A (zinc 
               
               
                   
                   
                   
                   
                 finger protein) 
               
               
                 224480_s_at 
                 3.1057024 
                 down 
                 AGPAT9 
                 1-acylglycerol-3-phosphate O- 
               
               
                   
                   
                   
                   
                 acyltransferase 9 
               
               
                 236359_at 
                 3.10485 
                 down 
                 SCN4B 
                 sodium channel, voltage-gated, type 
               
               
                   
                   
                   
                   
                 IV, beta 
               
               
                 229374_at 
                 3.1005714 
                 down 
                 EPHA4 
                 EPH receptor A4 
               
               
                 226617_at 
                 3.0999246 
                 down 
                 ARL5A 
                 ADP-ribosylation factor-like 5A 
               
               
                 221856_s_at 
                 3.0998528 
                 down 
                 FAM63A 
                 family with sequence similarity 63, 
               
               
                   
                   
                   
                   
                 member A 
               
               
                 238720_at 
                 3.0991333 
                 down 
                 OMG 
                 OMGP mRNA for oligodendrocyte- 
               
               
                   
                   
                   
                   
                 myelin glycoprotein 
               
               
                 214295_at 
                 3.0939116 
                 down 
                 KIAA0485 
                 hypothetical LOC57235 
               
               
                 218951_s_at 
                 3.0916145 
                 down 
                 PLCXD1 
                 phosphatidylinositol-specific 
               
               
                   
                   
                   
                   
                 phospholipase C, X domain containing 1 
               
               
                 223574_x_at 
                 3.0913527 
                 down 
                 PPP2R2C 
                 protein phosphatase 2 (formerly 2A), 
               
               
                   
                   
                   
                   
                 regulatory subunit B, gamma isoform 
               
               
                 224685_at 
                 3.0898316 
                 down 
                 MLLT4 
                 myeloid/lymphoid or mixed-lineage 
               
               
                   
                   
                   
                   
                 leukemia (trithorax homolog, 
               
               
                   
                   
                   
                   
                   Drosophila ); translocated to, 4 
               
               
                 231778_at 
                 3.089387 
                 down 
                 DLX3 
                 distal-less homeobox 3 
               
               
                 229290_at 
                 3.0886714 
                 down 
                 DAPL1 
                 death associated protein-like 1 
               
               
                 218829_s_at 
                 3.0885017 
                 down 
                 CHD7 
                 chromodomain helicase DNA binding 
               
               
                   
                   
                   
                   
                 protein 7 
               
               
                 223894_s_at 
                 3.0799034 
                 down 
                 AKTIP 
                 AKT interacting protein 
               
               
                 226187_at 
                 3.0795898 
                 down 
                 CDS1 
                 CDP-diacylglycerol synthase 
               
               
                   
                   
                   
                   
                 (phosphatidate cytidylyltransferase) 1 
               
               
                 227944_at 
                 3.077466 
                 down 
                 PTPN3 
                 protein tyrosine phosphatase, non- 
               
               
                   
                   
                   
                   
                 receptor type 3 
               
               
                 241813_at 
                 3.0757666 
                 down 
                 MBD1 
                 methyl-CpG binding domain protein 1 
               
               
                 203287_at 
                 3.0720277 
                 down 
                 LAD1 
                 ladinin 1 
               
               
                 229546_at 
                 3.0575104 
                 down 
                 LOC653602 
                 hypothetical LOC653602 
               
               
                 218849_s_at 
                 3.0525377 
                 down 
                 PPP1R13L 
                 protein phosphatase 1, regulatory 
               
               
                   
                   
                   
                   
                 (inhibitor) subunit 13 like 
               
               
                 1558281_a_at 
                 3.0518956 
                 down 
                 TMEM184A 
                 transmembrane protein 184A 
               
               
                 224579_at 
                 3.0447147 
                 down 
                 SLC38A1 
                 solute carrier family 38, member 1 
               
               
                 222830_at 
                 3.0440314 
                 down 
                 GRHL1 
                 grainyhead-like 1 ( Drosophila ) 
               
               
                 209605_at 
                 3.037887 
                 down 
                 TST 
                 thiosulfate sulfurtransferase 
               
               
                   
                   
                   
                   
                 (rhodanese) 
               
               
                 206632_s_at 
                 3.0369 
                 down 
                 APOBEC3B 
                 apolipoprotein B mRNA editing 
               
               
                   
                   
                   
                   
                 enzyme, catalytic polypeptide-like 3B 
               
               
                 213030_s_at 
                 3.0361433 
                 down 
                 PLXNA2 
                 plexin A2 
               
               
                 213787_s_at 
                 3.0355 
                 down 
                 EBP 
                 emopamil binding protein (sterol 
               
               
                   
                   
                   
                   
                 isomerase) 
               
               
                 212095_s_at 
                 3.0337477 
                 down 
                 MTUS1 
                 mitochondrial tumor suppressor 1 
               
               
                 1564308_a_at 
                 3.0335965 
                 down 
                 MPP7 
                 membrane protein, palmitoylated 7 
               
               
                   
                   
                   
                   
                 (MAGUK p55 subfamily member 7) 
               
               
                 204059_s_at 
                 3.028911 
                 down 
                 ME1 
                 malic enzyme 1, NADP(+)-dependent, 
               
               
                   
                   
                   
                   
                 cytosolic 
               
               
                 218922_s_at 
                 3.0278475 
                 down 
                 LASS4 
                 LAG1 homolog, ceramide synthase 4 
               
               
                 219990_at 
                 3.021536 
                 down 
                 E2F8 
                 E2F transcription factor 8 
               
               
                 244758_at 
                 3.021281 
                 down 
                 SCAND3 
                 SCAN domain containing 3 
               
               
                 201427_s_at 
                 3.011953 
                 down 
                 SEPP1 
                 selenoprotein P, plasma, 1 
               
               
                 237899_at 
                 3.0117605 
                 down 
                 LOC729994 
                 hypothetical LOC729994 
               
               
                 233814_at 
                 3.0052407 
                 down 
                 EFNA5 
                 Receptor tyrosine kinase ligand LERK- 
               
               
                   
                   
                   
                   
                 7 precursor (EPLG7) 
               
               
                 226829_at 
                 3.0025802 
                 down 
                 AFAP1L2 
                 actin filament associated protein 1-like 2 
               
               
                 203397_s_at 
                 3.002098 
                 down 
                 GALNT3 
                 UDP-N-acetyl-alpha-D- 
               
               
                   
                   
                   
                   
                 galactosamine:polypeptide N- 
               
               
                   
                   
                   
                   
                 acetylgalactosaminyltransferase 3 
               
               
                   
                   
                   
                   
                 (GalNAc-T3) 
               
               
                 222809_x_at 
                 3.0019972 
                 down 
                 C14orf65 
                 chromosome 14 open reading frame 65 
               
               
                 234725_s_at 
                 3.0007038 
                 down 
                 SEMA4B 
                 sema domain, immunoglobulin domain 
               
               
                   
                   
                   
                   
                 (Ig), transmembrane domain (TM) and 
               
               
                   
                   
                   
                   
                 short cytoplasmic domain, 
               
               
                   
                   
                   
                   
                 (semaphorin) 4B 
               
               
                 203560_at 
                 2.9994648 
                 down 
                 GGH 
                 gamma-glutamyl hydrolase (conjugase, 
               
               
                   
                   
                   
                   
                 folylpolygammaglutamyl hydrolase) 
               
               
                 233565_s_at 
                 2.9988334 
                 down 
                 SDCBP2 
                 syndecan binding protein (syntenin) 2 
               
               
                 1553212_at 
                 2.9964101 
                 down 
                 KRT78 
                 keratin 78 
               
               
                 204135_at 
                 2.9959981 
                 down 
                 FILIP1L 
                 filamin A interacting protein 1-like 
               
               
                 223278_at 
                 2.995849 
                 down 
                 GJB2 
                 gap junction protein, beta 2, 26 kDa 
               
               
                 227385_at 
                 2.9950788 
                 down 
                 PPAPDC2 
                 phosphatidic acid phosphatase type 2 
               
               
                   
                   
                   
                   
                 domain containing 2 
               
               
                 216347_s_at 
                 2.9949014 
                 down 
                 PPP1R13B 
                 protein phosphatase 1, regulatory 
               
               
                   
                   
                   
                   
                 (inhibitor) subunit 13B 
               
               
                 203359_s_at 
                 2.9933915 
                 down 
                 MYCBP 
                 c-myc binding protein 
               
               
                 242064_at 
                 2.9917743 
                 down 
                 SDK2 
                 sidekick homolog 2 (chicken) 
               
               
                 1553114_a_at 
                 2.9870312 
                 down 
                 PTK6 
                 PTK6 protein tyrosine kinase 6 
               
               
                 236266 at 
                 2.985503 
                 down 
                 RORA 
                 Hypothetical protein LOC283666, 
               
               
                   
                   
                   
                   
                 mRNA (cDNA clone 
               
               
                   
                   
                   
                   
                 IMAGE: 4750925) 
               
               
                 242317_at 
                 2.9845624 
                 down 
                 HIGD1A 
                 HIG1 domain family, member 1A 
               
               
                 209203_s_at 
                 2.984112 
                 down 
                 BICD2 
                 bicaudal D homolog 2 ( Drosophila ) 
               
               
                 226245_at 
                 2.9801052 
                 down 
                 KCTD1 
                 potassium channel tetramerisation 
               
               
                   
                   
                   
                   
                 domain containing 1 
               
               
                 214765_s_at 
                 2.9758816 
                 down 
                 NAAA 
                 N-acylethanolamine acid amidase 
               
               
                 223216_x_at 
                 2.9703996 
                 down 
                 ZNF395 
                 zinc finger protein 395 
               
               
                 221215_s_at 
                 2.9702475 
                 down 
                 RIPK4 
                 receptor-interacting serine-threonine 
               
               
                   
                   
                   
                   
                 kinase 4 
               
               
                 221081_s_at 
                 2.9699113 
                 down 
                 DENND2D 
                 DENN/MADD domain containing 2D 
               
               
                 202154_x_at 
                 2.9669414 
                 down 
                 TUBB3 
                 tubulin, beta 3 
               
               
                 208126_s_at 
                 2.9666116 
                 down 
                 CYP2C18 
                 cytochrome P450, family 2, subfamily 
               
               
                   
                   
                   
                   
                 C, polypeptide 18 
               
               
                 213476_x_at 
                 2.966195 
                 down 
                 TUBB3 
                 tubulin, beta 3 
               
               
                 203722_at 
                 2.9630923 
                 down 
                 ALDH4A1 
                 aldehyde dehydrogenase 4 family, 
               
               
                   
                   
                   
                   
                 member A1 
               
               
                 227135_at 
                 2.9602783 
                 down 
                 NAAA 
                 N-acylethanolamine acid amidase 
               
               
                 214705_at 
                 2.9595757 
                 down 
                 INADL 
                 InaD-like ( Drosophila ) 
               
               
                 211985_s_at 
                 2.9585447 
                 down 
                 CALM1 /// 
                 calmodulin 1 (phosphorylase kinase, 
               
               
                   
                   
                   
                 CALM2 /// 
                 delta) /// calmodulin 2 (phosphorylase 
               
               
                   
                   
                   
                 CALM3 
                 kinase, delta) /// calmodulin 3 
               
               
                   
                   
                   
                   
                 (phosphorylase kinase, delta) 
               
               
                 238513_at 
                 2.9496446 
                 down 
                 PRRG4 
                 Proline rich Gla (G-carboxyglutamic 
               
               
                   
                   
                   
                   
                 acid) 4 (transmembrane), mRNA 
               
               
                   
                   
                   
                   
                 (cDNA clone MGC: 19793 
               
               
                   
                   
                   
                   
                 IMAGE: 3841745) 
               
               
                 243837_x_at 
                 2.947061 
                 down 
                 LOC100128500 
                 hypothetical protein LOC100128500 
               
               
                 218677_at 
                 2.9463606 
                 down 
                 S100A14 
                 S100 calcium binding protein A14 
               
               
                 218900_at 
                 2.9451632 
                 down 
                 CNNM4 
                 cyclin M4 
               
               
                 220266_s_at 
                 2.9415443 
                 down 
                 KLF4 
                 Kruppel-like factor 4 (gut) 
               
               
                 204341_at 
                 2.9409094 
                 down 
                 TRIM16 
                 tripartite motif-containing 16 
               
               
                 230769_at 
                 2.939519 
                 down 
                 DENND2C 
                 DENN/MADD domain containing 2C 
               
               
                 232693_s_at 
                 2.9363637 
                 down 
                 FBXO16 /// 
                 F-box protein 16 /// zinc finger protein 
               
               
                   
                   
                   
                 ZNF395 
                 395 
               
               
                 226246_at 
                 2.9359393 
                 down 
                 KCTD1 
                 potassium channel tetramerisation 
               
               
                   
                   
                   
                   
                 domain containing 1 
               
               
                 226421 at 
                 2.933277 
                 down 
                 AMMECR1 
                 Alport syndrome, mental retardation, 
               
               
                   
                   
                   
                   
                 midface hypoplasia and elliptocytosis 
               
               
                   
                   
                   
                   
                 chromosomal region gene 1 
               
               
                 225655_at 
                 2.9276872 
                 down 
                 UHRF1 
                 ubiquitin-like with PHD and ring 
               
               
                   
                   
                   
                   
                 finger domains 1 
               
               
                 222717_at 
                 2.926197 
                 down 
                 SDPR 
                 serum deprivation response 
               
               
                   
                   
                   
                   
                 (phosphatidylserine binding protein) 
               
               
                 235871_at 
                 2.9253323 
                 down 
                 LIPH 
                 lipase, member H 
               
               
                 223339_at 
                 2.9252036 
                 down 
                 ATPIF1 
                 ATPase inhibitory factor 1 
               
               
                 223233_s_at 
                 2.9242868 
                 down 
                 CGN 
                 cingulin 
               
               
                 225051_at 
                 2.9183056 
                 down 
                 EPB41 
                 erythrocyte membrane protein band 4.1 
               
               
                   
                   
                   
                   
                 (elliptocytosis 1, RH-linked) 
               
               
                 209372_x_at 
                 2.914044 
                 down 
                 TUBB2A /// 
                 tubulin, beta 2A /// tubulin, beta 2B 
               
               
                   
                   
                   
                 TUBB2B 
               
               
                 224495_at 
                 2.9137444 
                 down 
                 TMEM107 
                 transmembrane protein 107 
               
               
                 218722_s_at 
                 2.9108763 
                 down 
                 CCDC51 
                 coiled-coil domain containing 51 
               
               
                 228221_at 
                 2.9098802 
                 down 
                 SLC44A3 
                 solute carrier family 44, member 3 
               
               
                 207955_at 
                 2.907911 
                 down 
                 CCL27 
                 chemokine (C-C motif) ligand 27 
               
               
                 206094_x_at 
                 2.9065409 
                 down 
                 UGT1A1 /// 
                 UDP glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A10 /// 
                 polypeptide A1 /// UDP 
               
               
                   
                   
                   
                 UGT1A3 /// 
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A4 /// 
                 polypeptide A10 /// UDP 
               
               
                   
                   
                   
                 UGT1A5 /// 
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A6 /// 
                 polypeptide A3 /// UDP 
               
               
                   
                   
                   
                 UGT1A7 /// 
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A8 /// 
                 polypeptide A4 /// UDP 
               
               
                   
                   
                   
                 UGT1A9 
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A5 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A6 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A7 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A8 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A9 
               
               
                 231830_x_at 
                 2.902842 
                 down 
                 RAB11FIP1 
                 RAB11 family interacting protein 1 
               
               
                   
                   
                   
                   
                 (class I) 
               
               
                 1554966_a_at 
                 2.9024658 
                 down 
                 FILIP1L 
                 filamin A interacting protein 1-like 
               
               
                 226959_at 
                 2.9023726 
                 down 
                 LOC283070 
                 CDNA FLJ40058 fis, clone 
               
               
                   
                   
                   
                   
                 TCOLN1000180 
               
               
                 206400_at 
                 2.9014132 
                 down 
                 LGALS7 /// 
                 lectin, galactoside-binding, soluble, 7 
               
               
                   
                   
                   
                 LGALS7B 
                 /// lectin, galactoside-binding, soluble, 
               
               
                   
                   
                   
                   
                 7B 
               
               
                 1554246_at 
                 2.8979917 
                 down 
                 C1orf210 
                 chromosome 1 open reading frame 210 
               
               
                 227736_at 
                 2.8947847 
                 down 
                 C10orf99 
                 chromosome 10 open reading frame 99 
               
               
                 221123_x_at 
                 2.8909688 
                 down 
                 ZNF395 
                 zinc finger protein 395 
               
               
                 222890_at 
                 2.8908694 
                 down 
                 CCDC113 
                 coiled-coil domain containing 113 
               
               
                 208190_s_at 
                 2.890325 
                 down 
                 LSR 
                 lipolysis stimulated lipoprotein 
               
               
                   
                   
                   
                   
                 receptor 
               
               
                 229396_at 
                 2.8896506 
                 down 
                 OVOL1 
                 ovo-like 1( Drosophila ) 
               
               
                 227034_at 
                 2.888465 
                 down 
                 ANKRD57 
                 ankyrin repeat domain 57 
               
               
                 219648_at 
                 2.8866937 
                 down 
                 MREG 
                 melanoregulin 
               
               
                 218792_s_at 
                 2.8844924 
                 down 
                 BSPRY 
                 B-box and SPRY domain containing 
               
               
                 204542_at 
                 2.8817751 
                 down 
                 ST6GALNAC2 
                 ST6 (alpha-N-acetyl-neuraminyl-2,3- 
               
               
                   
                   
                   
                   
                 beta-galactosyl-1,3)-N- 
               
               
                   
                   
                   
                   
                 acetylgalactosaminide alpha-2,6- 
               
               
                   
                   
                   
                   
                 sialyltransferase 2 
               
               
                 238962_at 
                 2.877806 
                 down 
                 ZNF681 
                 zinc finger protein 681 
               
               
                 227964_at 
                 2.877196 
                 down 
                 FRMD8 
                 FERM domain containing 8 
               
               
                 238964_at 
                 2.8724544 
                 down 
                 FIGN 
                 fidgetin 
               
               
                 201564_s_at 
                 2.8720455 
                 down 
                 FSCN1 
                 fascin homolog 1, actin-bundling 
               
               
                   
                   
                   
                   
                 protein (Strongylocentrotus 
               
               
                   
                   
                   
                   
                 purpuratus) 
               
               
                 38340_at 
                 2.8708196 
                 down 
                 HIP1R 
                 huntingtin interacting protein 1 related 
               
               
                 218032_at 
                 2.8703704 
                 down 
                 SNN 
                 stannin 
               
               
                 204547_at 
                 2.8703067 
                 down 
                 RAB40B 
                 RAB40B, member RAS oncogene 
               
               
                   
                   
                   
                   
                 family 
               
               
                 213506_at 
                 2.8534102 
                 down 
                 F2RL1 
                 coagulation factor II (thrombin) 
               
               
                   
                   
                   
                   
                 receptor-like 1 
               
               
                 235095_at 
                 2.851771 
                 down 
                 CCDC64B 
                 coiled-coil domain containing 64B 
               
               
                 202962_at 
                 2.8498514 
                 down 
                 KIF13B 
                 kinesin family member 13B 
               
               
                 200606_at 
                 2.8482468 
                 down 
                 DSP 
                 desmoplakin 
               
               
                 220578_at 
                 2.8452191 
                 down 
                 ADAMTSL4 
                 ADAMTS-like 4 
               
               
                 218789_s_at 
                 2.840476 
                 down 
                 C11orf71 
                 chromosome 11 open reading frame 71 
               
               
                 242093_at 
                 2.8397858 
                 down 
                 SYTL5 
                 synaptotagmin-like 5 
               
               
                 228975_at 
                 2.8345933 
                 down 
                 SP6 
                 Sp6 transcription factor 
               
               
                 1569555_at 
                 2.832668 
                 down 
                 GDA 
                 guanine deaminase 
               
               
                 201694_s_at 
                 2.8325536 
                 down 
                 EGR1 
                 early growth response 1 
               
               
                 210128_s_at 
                 2.8322942 
                 down 
                 LTB4R 
                 leukotriene B4 receptor 
               
               
                 213805_at 
                 2.8317797 
                 down 
                 ABHD5 
                 abhydrolase domain containing 5 
               
               
                 238762_at 
                 2.8312757 
                 down 
                 MTHFD2L 
                 methylenetetrahydrofolate 
               
               
                   
                   
                   
                   
                 dehydrogenase (NADP+ dependent) 2- 
               
               
                   
                   
                   
                   
                 like 
               
               
                 1558111_at 
                 2.8277514 
                 down 
                 MBNL1 
                 muscleblind-like ( Drosophila ) 
               
               
                 223000_s_at 
                 2.8271255 
                 down 
                 F11R 
                 F11 receptor 
               
               
                 227998_at 
                 2.8236406 
                 down 
                 S100A16 
                 S100 calcium binding protein A16 
               
               
                 238206_at 
                 2.8226795 
                 down 
                 RXFP1 
                 relaxin/insulin-like family peptide 
               
               
                   
                   
                   
                   
                 receptor 1 
               
               
                 1552648_a_at 
                 2.82174 
                 down 
                 TNFRSF10A 
                 tumor necrosis factor receptor 
               
               
                   
                   
                   
                   
                 superfamily, member 10a 
               
               
                 235850_at 
                 2.8215306 
                 down 
                 WDR5B 
                 WD repeat domain 5B 
               
               
                 200636_s_at 
                 2.816918 
                 down 
                 PTPRF 
                 protein tyrosine phosphatase, receptor 
               
               
                   
                   
                   
                   
                 type, F 
               
               
                 218779_x_at 
                 2.813133 
                 down 
                 EPS8L1 
                 EPS8-like 1 
               
               
                 220456_at 
                 2.811995 
                 down 
                 SPTLC3 
                 serine palmitoyltransferase, long chain 
               
               
                   
                   
                   
                   
                 base subunit 3 
               
               
                 210652_s_at 
                 2.8102167 
                 down 
                 TTC39A 
                 tetratricopeptide repeat domain 39A 
               
               
                 239853_at 
                 2.809029 
                 down 
                 KLC3 
                 kinesin light chain 3 
               
               
                 205765_at 
                 2.8077855 
                 down 
                 CYP3A5 
                 cytochrome P450, family 3, subfamily 
               
               
                   
                   
                   
                   
                 A, polypeptide 5 
               
               
                 1552620_at 
                 2.8073084 
                 down 
                 SPRR4 
                 small proline-rich protein 4 
               
               
                 225779_at 
                 2.8072405 
                 down 
                 SLC27A4 
                 solute carrier family 27 (fatty acid 
               
               
                   
                   
                   
                   
                 transporter), member 4 
               
               
                 203699_s_at 
                 2.806607 
                 down 
                 DIO2 
                 deiodinase, iodothyronine, type II 
               
               
                 231810_at 
                 2.8063636 
                 down 
                 BRI3BP 
                 Cervical cancer oncogene binding 
               
               
                   
                   
                   
                   
                 protein 
               
               
                 221893_s_at 
                 2.7909083 
                 down 
                 ADCK2 
                 aarF domain containing kinase 2 
               
               
                 209260_at 
                 2.7901292 
                 down 
                 SFN 
                 stratifin 
               
               
                 205054_at 
                 2.7879531 
                 down 
                 NEB 
                 nebulin 
               
               
                 213050_at 
                 2.7861958 
                 down 
                 COBL 
                 cordon-bleu homolog (mouse) 
               
               
                 218028_at 
                 2.7856884 
                 down 
                 ELOVL1 
                 elongation of very long chain fatty 
               
               
                   
                   
                   
                   
                 acids (FEN1/Elo2, SUR4/Elo3, yeast)- 
               
               
                   
                   
                   
                   
                 like 1 
               
               
                 224496_s_at 
                 2.7819924 
                 down 
                 TMEM107 
                 transmembrane protein 107 
               
               
                 1553031_at 
                 2.7813523 
                 down 
                 GPR115 
                 G protein-coupled receptor 115 
               
               
                 223497_at 
                 2.7785342 
                 down 
                 FAM135A 
                 family with sequence similarity 135, 
               
               
                   
                   
                   
                   
                 member A 
               
               
                 204856_at 
                 2.7779574 
                 down 
                 B3GNT3 
                 UDP-GlcNAc:betaGal beta-1,3-N- 
               
               
                   
                   
                   
                   
                 acetylglucosaminyltransferase 3 
               
               
                 220911_s_at 
                 2.7676141 
                 down 
                 KIAA1305 
                 KIAA1305 
               
               
                 219696_at 
                 2.7632923 
                 down 
                 DENND1B 
                 DENN/MADD domain containing 1B 
               
               
                 1559096_x_at 
                 2.758654 
                 down 
                 FBXO9 
                 F-box protein 9 
               
               
                 204976_s_at 
                 2.7562022 
                 down 
                 AMMECR1 
                 Alport syndrome, mental retardation, 
               
               
                   
                   
                   
                   
                 midface hypoplasia and elliptocytosis 
               
               
                   
                   
                   
                   
                 chromosomal region gene 1 
               
               
                 218149_s_at 
                 2.7463727 
                 down 
                 ZNF395 
                 zinc finger protein 395 
               
               
                 229513_at 
                 2.7461805 
                 down 
                 STRBP 
                 Chromosome 9 open reading frame 45, 
               
               
                   
                   
                   
                   
                 mRNA (cDNA clone MGC: 45613 
               
               
                   
                   
                   
                   
                 IMAGE: 2989018) 
               
               
                 235605_at 
                 2.7404695 
                 down 
                 CASZ1 
                 castor zinc finger 1 
               
               
                 213201_s_at 
                 2.7397995 
                 down 
                 TNNT1 
                 troponin T type 1 (skeletal, slow) 
               
               
                 204141_at 
                 2.738532 
                 down 
                 TUBB2A 
                 tubulin, beta 2A 
               
               
                 230398_at 
                 2.7380996 
                 down 
                 TNS4 
                 tensin 4 
               
               
                 238013_at 
                 2.7366548 
                 down 
                 PLEKHA2 
                 pleckstrin homology domain 
               
               
                   
                   
                   
                   
                 containing, family A (phosphoinositide 
               
               
                   
                   
                   
                   
                 binding specific) member 2 
               
               
                 204532_x_at 
                 2.7337391 
                 down 
                 UGT1A1 /// 
                 UDP glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A10 /// 
                 polypeptide A1 /// UDP 
               
               
                   
                   
                   
                 UGT1A4 /// 
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A6 /// 
                 polypeptide A10 /// UDP 
               
               
                   
                   
                   
                 UGT1A8 /// 
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                 UGT1A9 
                 polypeptide A4 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A6 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A8 /// UDP 
               
               
                   
                   
                   
                   
                 glucuronosyltransferase 1 family, 
               
               
                   
                   
                   
                   
                 polypeptide A9 
               
               
                 204554_at 
                 2.7311485 
                 down 
                 PPP1R3D 
                 protein phosphatase 1, regulatory 
               
               
                   
                   
                   
                   
                 (inhibitor) subunit 3D 
               
               
                 205552_s_at 
                 2.7279844 
                 down 
                 OAS1 
                 2′,5′-oligoadenylate synthetase 1, 
               
               
                   
                   
                   
                   
                 40/46 kDa 
               
               
                 228565_at 
                 2.7276409 
                 down 
                 KIAA1804 
                 mixed lineage kinase 4 
               
               
                 228155_at 
                 2.7267504 
                 down 
                 C10orf57 /// 
                 chromosome 10 open reading frame 57 
               
               
                   
                   
                   
                 C10orf58 
                 /// chromosome 10 open reading frame 
               
               
                   
                   
                   
                   
                 58 
               
               
                 223427_s_at 
                 2.7255745 
                 down 
                 EPB41L4B 
                 erythrocyte membrane protein band 4.1 
               
               
                   
                   
                   
                   
                 like 4B 
               
               
                 204867_at 
                 2.7246413 
                 down 
                 GCHFR 
                 GTP cyclohydrolase I feedback 
               
               
                   
                   
                   
                   
                 regulator 
               
               
                 221802_s_at 
                 2.723564 
                 down 
                 KIAA1598 
                 KIAA1598 
               
               
                 231807_at 
                 2.7220626 
                 down 
                 KIAA1217 
                 KIAA1217 
               
               
                 205818_at 
                 2.7216518 
                 down 
                 DBC1 
                 deleted in bladder cancer 1 
               
               
                 226106_at 
                 2.7186909 
                 down 
                 RNF141 
                 ring finger protein 141 
               
               
                 205251_at 
                 2.718256 
                 down 
                 PER2 
                 period homolog 2 ( Drosophila ) 
               
               
                 201249_at 
                 2.7168527 
                 down 
                 SLC2A1 
                 solute carrier family 2 (facilitated 
               
               
                   
                   
                   
                   
                 glucose transporter), member 1 
               
               
                 215891_s_at 
                 2.712683 
                 down 
                 GM2A 
                 GM2 ganglioside activator 
               
               
                 206102_at 
                 2.7067106 
                 down 
                 GINS1 
                 GINS complex subunit 1 (Psf1 
               
               
                   
                   
                   
                   
                 homolog) 
               
               
                 205676_at 
                 2.704932 
                 down 
                 CYP27B1 
                 cytochrome P450, family 27, 
               
               
                   
                   
                   
                   
                 subfamily B, polypeptide 1 
               
               
                 230475_at 
                 2.704732 
                 down 
                 C15orf59 
                 chromosome 15 open reading frame 59 
               
               
                 1554878_a_at 
                 2.7038002 
                 down 
                 ABCD3 
                 ATP-binding cassette, sub-family D 
               
               
                   
                   
                   
                   
                 (ALD), member 3 
               
               
                 226968_at 
                 2.7027438 
                 down 
                 KIF1B 
                 kinesin family member 1B 
               
               
                 229997_at 
                 2.7027018 
                 down 
                 VANGL1 
                 vang-like 1 (van gogh,  Drosophila ) 
               
               
                 222833_at 
                 2.6967285 
                 down 
                 LPCAT2 
                 lysophosphatidylcholine 
               
               
                   
                   
                   
                   
                 acyltransferase 2 
               
               
                 202449_s_at 
                 2.6946986 
                 down 
                 RXRA 
                 retinoid X receptor, alpha 
               
               
                 222912_at 
                 2.6944733 
                 down 
                 ARRB1 
                 arrestin, beta 1 
               
               
                 1555292_at 
                 2.6942291 
                 down 
                 FAM40B 
                 family with sequence similarity 40, 
               
               
                   
                   
                   
                   
                 member B 
               
               
                 240303_at 
                 2.6937366 
                 down 
                 TMC5 
                 Transmembrane channel-like 5, mRNA 
               
               
                   
                   
                   
                   
                 (cDNA clone IMAGE: 5265527) 
               
               
                 203641_s_at 
                 2.6928594 
                 down 
                 COBLL1 
                 COBL-like 1 
               
               
                 208999_at 
                 2.6917293 
                 down 
                 40064 
                 septin 8 
               
               
                 210716_s_at 
                 2.6889458 
                 down 
                 CLIP1 
                 CAP-GLY domain containing linker 
               
               
                   
                   
                   
                   
                 protein 1 
               
               
                 204503_at 
                 2.6869638 
                 down 
                 EVPL 
                 envoplakin 
               
               
                 220658_s_at 
                 2.6862872 
                 down 
                 ARNTL2 
                 aryl hydrocarbon receptor nuclear 
               
               
                   
                   
                   
                   
                 translocator-like 2 
               
               
                 57163_at 
                 2.6833892 
                 down 
                 ELOVL1 
                 elongation of very long chain fatty 
               
               
                   
                   
                   
                   
                 acids (FEN1/Elo2, SUR4/Elo3, yeast)- 
               
               
                   
                   
                   
                   
                 like 1 
               
               
                 230630_at 
                 2.682703 
                 down 
                 AK3L1 /// 
                 adenylate kinase 3-like 1 /// adenylate 
               
               
                   
                   
                   
                 AK3L2 
                 kinase 3-like 2 
               
               
                 226690_at 
                 2.681126 
                 down 
                 ADCYAP1R1 
                 CDNA FLJ39226 fis, clone 
               
               
                   
                   
                   
                   
                 OCBBF2007232 
               
               
                 218845_at 
                 2.680393 
                 down 
                 DUSP22 
                 dual specificity phosphatase 22 
               
               
                 212702_s_at 
                 2.680374 
                 down 
                 BICD2 
                 bicaudal D homolog 2 ( Drosophila ) 
               
               
                 224516_s_at 
                 2.67937 
                 down 
                 CXXC5 
                 CXXC finger 5 
               
               
                 201732_s_at 
                 2.6788018 
                 down 
                 CLCN3 
                 chloride channel 3 
               
               
                 239273_s_at 
                 2.6781023 
                 down 
                 MMP28 
                 matrix metallopeptidase 28 
               
               
                 205739_x_at 
                 2.678095 
                 down 
                 ZNF107 
                 zinc finger protein 107 
               
               
                 225597_at 
                 2.6771371 
                 down 
                 SLC45A4 
                 solute carrier family 45, member 4 
               
               
                 204430_s_at 
                 2.6757636 
                 down 
                 SLC2A5 
                 solute carrier family 2 (facilitated 
               
               
                   
                   
                   
                   
                 glucose/fructose transporter), member 5 
               
               
                 212921_at 
                 2.6731923 
                 down 
                 SMYD2 
                 SET and MYND domain containing 2 
               
               
                 242123_at 
                 2.6718855 
                 down 
                 PAQR7 
                 progestin and adipoQ receptor family 
               
               
                   
                   
                   
                   
                 member VII 
               
               
                 227271_at 
                 2.6716337 
                 down 
                 FGF11 
                 fibroblast growth factor 11 
               
               
                 225987_at 
                 2.669063 
                 down 
                 STEAP4 
                 STEAP family member 4 
               
               
                 209790_s_at 
                 2.6684937 
                 down 
                 CASP6 
                 caspase 6, apoptosis-related cysteine 
               
               
                   
                   
                   
                   
                 peptidase 
               
               
                 222477_s_at 
                 2.6653984 
                 down 
                 TM7SF3 
                 transmembrane 7 superfamily member 3 
               
               
                 203411_s_at 
                 2.663246 
                 down 
                 LMNA 
                 lamin A/C 
               
               
                 224580_at 
                 2.660365 
                 down 
                 SLC38A1 
                 solute carrier family 38, member 1 
               
               
                 205569_at 
                 2.6560183 
                 down 
                 LAMP3 
                 lysosomal-associated membrane 
               
               
                   
                   
                   
                   
                 protein 3 
               
               
                 236496_at 
                 2.653787 
                 down 
                 DEGS2 
                 degenerative spermatocyte homolog 2, 
               
               
                   
                   
                   
                   
                 lipid desaturase ( Drosophila ) 
               
               
                 231775_at 
                 2.652064 
                 down 
                 TNFRSF10A 
                 tumor necrosis factor receptor 
               
               
                   
                   
                   
                   
                 superfamily, member 10a 
               
               
                 211950_at 
                 2.6516557 
                 down 
                 UBR4 
                 ubiquitin protein ligase E3 component 
               
               
                   
                   
                   
                   
                 n-recognin 4 
               
               
                 207431_s_at 
                 2.6450002 
                 down 
                 DEGS1 
                 degenerative spermatocyte homolog 1, 
               
               
                   
                   
                   
                   
                 lipid desaturase ( Drosophila ) 
               
               
                 200635_s_at 
                 2.6411211 
                 down 
                 PTPRF 
                 protein tyrosine phosphatase, receptor 
               
               
                   
                   
                   
                   
                 type, F 
               
               
                 230252_at 
                 2.640716 
                 down 
                 LPAR5 
                 lysophosphatidic acid receptor 5 
               
               
                 226584_s_at 
                 2.6402125 
                 down 
                 FAM110A 
                 family with sequence similarity 110, 
               
               
                   
                   
                   
                   
                 member A 
               
               
                 233955_x_at 
                 2.6379757 
                 down 
                 CXXC5 
                 CXXC finger 5 
               
               
                 213624_at 
                 2.63438 
                 down 
                 SMPDL3A 
                 sphingomyelin phosphodiesterase, 
               
               
                   
                   
                   
                   
                 acid-like 3A 
               
               
                 212449_s_at 
                 2.632708 
                 down 
                 LYPLA1 
                 lysophospholipase I 
               
               
                 231755_at 
                 2.6293309 
                 down 
                 IL1F8 
                 interleukin 1 family, member 8 (eta) 
               
               
                 216836_s_at 
                 2.6269796 
                 down 
                 ERBB2 
                 v-erb-b2 erythroblastic leukemia viral 
               
               
                   
                   
                   
                   
                 oncogene homolog 2, 
               
               
                   
                   
                   
                   
                 neuro/glioblastoma derived oncogene 
               
               
                   
                   
                   
                   
                 homolog (avian) 
               
               
                 212086_x_at 
                 2.6258197 
                 down 
                 LMNA 
                 lamin A/C 
               
               
                 211984_at 
                 2.623374 
                 down 
                 CALM1 /// 
                 calmodulin 1 (phosphorylase kinase, 
               
               
                   
                   
                   
                 CALM2 /// 
                 delta) /// calmodulin 2 (phosphorylase 
               
               
                   
                   
                   
                 CALM3 
                 kinase, delta) /// calmodulin 3 
               
               
                   
                   
                   
                   
                 (phosphorylase kinase, delta) 
               
               
                 229522_at 
                 2.6224053 
                 down 
                 SDR42E1 
                 short chain dehydrogenase/reductase 
               
               
                   
                   
                   
                   
                 family 42E, member 1 
               
               
                 229545_at 
                 2.6210556 
                 down 
                 FERMT1 
                 fermitin family homolog 1 
               
               
                   
                   
                   
                   
                 ( Drosophila ) 
               
               
                 218373_at 
                 2.6198244 
                 down 
                 AKTIP 
                 AKT interacting protein 
               
               
                 209502_s_at 
                 2.6195574 
                 down 
                 BAIAP2 
                 BAI1-associated protein 2 
               
               
                 1554541_a_at 
                 2.6188276 
                 down 
                 GPRIN2 
                 G protein regulated inducer of neurite 
               
               
                   
                   
                   
                   
                 outgrowth 2 
               
               
                 228067_at 
                 2.6184916 
                 down 
                 C2orf55 
                 chromosome 2 open reading frame 55 
               
               
                 218174_s_at 
                 2.6181328 
                 down 
                 C10orf57 
                 chromosome 10 open reading frame 57 
               
               
                 234931_at 
                 2.6159503 
                 down 
                 AYP1p1 
                 AYP1 pseudogene 1 
               
               
                 1553906_s_at 
                 2.6134384 
                 down 
                 FGD2 
                 FYVE, RhoGEF and PH domain 
               
               
                   
                   
                   
                   
                 containing 2 
               
               
                 232893_at 
                 2.6126134 
                 down 
                 LMBRD2 
                 LMBR1 domain containing 2 
               
               
                 215380_s_at 
                 2.6118267 
                 down 
                 GGCT 
                 gamma-glutamyl cyclotransferase 
               
               
                 1552691_at 
                 2.6064768 
                 down 
                 ARL11 
                 ADP-ribosylation factor-like 11 
               
               
                 209930_s_at 
                 2.603701 
                 down 
                 NFE2 
                 nuclear factor (erythroid-derived 2), 
               
               
                   
                   
                   
                   
                 45 kDa 
               
               
                 225327_at 
                 2.6030378 
                 down 
                 KIAA1370 
                 KIAA1370 
               
               
                 226198_at 
                 2.602333 
                 down 
                 TOM1L2 
                 target of myb1-like 2 (chicken) 
               
               
                 210872_x_at 
                 2.6014338 
                 down 
                 GAS7 
                 growth arrest-specific 7 
               
               
                 200831_s_at 
                 2.6004403 
                 down 
                 SCD 
                 stearoyl-CoA desaturase (delta-9- 
               
               
                   
                   
                   
                   
                 desaturase) 
               
               
                 227701_at 
                 2.5987177 
                 down 
                 C10orf118 
                 chromosome 10 open reading frame 
               
               
                   
                   
                   
                   
                 118 
               
               
                 230986_at 
                 2.5968971 
                 down 
                 KLF8 
                 CDNA selection clone ADS40 
               
               
                 220944_at 
                 2.5951362 
                 down 
                 PGLYRP4 
                 peptidoglycan recognition protein 4 
               
               
                 225611_at 
                 2.5939965 
                 down 
                 LOC100128443 
                 hypothetical protein LOC100128443 /// 
               
               
                   
                   
                   
                 /// MAST4 
                 microtubule associated 
               
               
                   
                   
                   
                   
                 serine/threonine kinase family member 4 
               
               
                 237159_x_at 
                 2.5931563 
                 down 
                 AP1S3 
                 adaptor-related protein complex 1, 
               
               
                   
                   
                   
                   
                 sigma 3 subunit 
               
               
                 208977_x_at 
                 2.5907562 
                 down 
                 TUBB2C 
                 tubulin, beta 2C 
               
               
                 202735_at 
                 2.5905764 
                 down 
                 EBP 
                 emopamil binding protein (sterol 
               
               
                   
                   
                   
                   
                 isomerase) 
               
               
                 203535_at 
                 2.590224 
                 down 
                 S100A9 
                 S100 calcium binding protein A9 
               
               
                 221698_s_at 
                 2.5864825 
                 down 
                 CLEC7A 
                 C-type lectin domain family 7, member A 
               
               
                 202596_at 
                 2.5864198 
                 down 
                 ENSA 
                 endosulfine alpha 
               
               
                 229776_at 
                 2.5856552 
                 down 
                 SLCO3A1 
                 solute carrier organic anion transporter 
               
               
                   
                   
                   
                   
                 family, member 3A1 
               
               
                 218802_at 
                 2.5770578 
                 down 
                 CCDC109B 
                 coiled-coil domain containing 109B 
               
               
                 219230_at 
                 2.5765135 
                 down 
                 TMEM100 
                 transmembrane protein 100 
               
               
                 226769_at 
                 2.5724943 
                 down 
                 FIBIN 
                 fin bud initiation factor homolog 
               
               
                   
                   
                   
                   
                 (zebrafish) 
               
               
                 211661_x_at 
                 2.5699801 
                 down 
                 PTAFR 
                 platelet-activating factor receptor 
               
               
                 218556_at 
                 2.5698657 
                 down 
                 ORMDL2 
                 ORM1-like 2 ( S. cerevisiae ) 
               
               
                 209218_at 
                 2.5663185 
                 down 
                 SQLE 
                 squalene epoxidase 
               
               
                 1557828_a_at 
                 2.564371 
                 down 
                 C5orf28 
                 CDNA FLJ36759 fis, clone 
               
               
                   
                   
                   
                   
                 UTERU2018566 
               
               
                 207169_x_at 
                 2.5612175 
                 down 
                 DDR1 
                 discoidin domain receptor tyrosine 
               
               
                   
                   
                   
                   
                 kinase 1 
               
               
                 213174_at 
                 2.5579307 
                 down 
                 TTC9 
                 tetratricopeptide repeat domain 9 
               
               
                 236760_at 
                 2.5566704 
                 down 
                 AMMECR1 
                 Alport syndrome, mental retardation, 
               
               
                   
                   
                   
                   
                 midface hypoplasia and elliptocytosis 
               
               
                   
                   
                   
                   
                 chromosomal region, gene 1, mRNA 
               
               
                   
                   
                   
                   
                 (cDNA clone IMAGE: 5405764) 
               
               
                 224008_s_at 
                 2.5530894 
                 down 
                 KCNK7 
                 potassium channel, subfamily K, 
               
               
                   
                   
                   
                   
                 member 7 
               
               
                 203970_s_at 
                 2.546217 
                 down 
                 PEX3 
                 peroxisomal biogenesis factor 3 
               
               
                 239533_at 
                 2.539709 
                 down 
                 GPR155 
                 G protein-coupled receptor 155 
               
               
                 202814_s_at 
                 2.5392075 
                 down 
                 HEXIM1 
                 hexamethylene bis-acetamide inducible 1 
               
               
                 212479_s_at 
                 2.5390153 
                 down 
                 RMND5A 
                 required for meiotic nuclear division 5 
               
               
                   
                   
                   
                   
                 homolog A ( S. cerevisiae ) 
               
               
                 208188_at 
                 2.5387063 
                 down 
                 KRT9 
                 keratin 9 
               
               
                 218888_s_at 
                 2.537066 
                 down 
                 NETO2 
                 neuropilin (NRP) and tolloid (TLL)- 
               
               
                   
                   
                   
                   
                 like 2 
               
               
                 202081_at 
                 2.5366287 
                 down 
                 IER2 
                 immediate early response 2 
               
               
                 1569065_s_at 
                 2.5342972 
                 down 
                 C15orf62 
                 chromosome 15 open reading frame 62 
               
               
                 238687_x_at 
                 2.531887 
                 down 
                 ZNF770 
                 zinc finger protein 770 
               
               
                 214639_s_at 
                 2.5304656 
                 down 
                 HOXA1 
                 homeobox A1 
               
               
                 200864_s_at 
                 2.5266373 
                 down 
                 RAB11A 
                 RAB11A, member RAS oncogene 
               
               
                   
                   
                   
                   
                 family 
               
               
                 221044_s_at 
                 2.5264642 
                 down 
                 TRIM34 /// 
                 tripartite motif-containing 34 /// 
               
               
                   
                   
                   
                 TRIM6 /// 
                 tripartite motif-containing 6 /// TRIM6- 
               
               
                   
                   
                   
                 TRIM6- 
                 TRIM34 readthrough transcript 
               
               
                   
                   
                   
                 TRIM34 
               
               
                 226002_at 
                 2.5262494 
                 down 
                 GAB1 
                 GRB2-associated binding protein 1 
               
               
                 218237_s_at 
                 2.5249395 
                 down 
                 SLC38A1 
                 solute carrier family 38, member 1 
               
               
                 228320_x_at 
                 2.5236611 
                 down 
                 CCDC64 
                 coiled-coil domain containing 64 
               
               
                 218094_s_at 
                 2.5231547 
                 down 
                 DBNDD2 /// 
                 dysbindin (dystrobrevin binding 
               
               
                   
                   
                   
                 SYS1- 
                 protein 1) domain containing 2 /// 
               
               
                   
                   
                   
                 DBNDD2 
                 SYS1-DBNDD2 readthrough transcript 
               
               
                 204451_at 
                 2.5215912 
                 down 
                 FZD1 
                 frizzled homolog 1 ( Drosophila ) 
               
               
                 237030_at 
                 2.5207937 
                 down 
                 ACPP 
                 acid phosphatase, prostate 
               
               
                 203215_s_at 
                 2.5199451 
                 down 
                 MYO6 
                 myosin VI 
               
               
                 204334_at 
                 2.5181212 
                 down 
                 KLF7 
                 Kruppel-like factor 7 (ubiquitous) 
               
               
                 221610_s_at 
                 2.5177839 
                 down 
                 STAP2 
                 signal transducing adaptor family 
               
               
                   
                   
                   
                   
                 member 2 
               
               
                 224414_s_at 
                 2.5176234 
                 down 
                 CARD6 
                 caspase recruitment domain family, 
               
               
                   
                   
                   
                   
                 member 6 
               
               
                 219428_s_at 
                 2.5164838 
                 down 
                 PXMP4 
                 peroxisomal membrane protein 4, 
               
               
                   
                   
                   
                   
                 24 kDa 
               
               
                 223805_at 
                 2.5157578 
                 down 
                 OSBPL6 
                 oxysterol binding protein-like 6 
               
               
                 208534_s_at 
                 2.515689 
                 down 
                 RASA4 /// 
                 RAS p21 protein activator 4 /// RAS 
               
               
                   
                   
                   
                 RASA4P 
                 p21 protein activator 4 pseudogene 
               
               
                 222725_s_at 
                 2.5121596 
                 down 
                 PALMD 
                 palmdelphin 
               
               
                 207847_s_at 
                 2.5091352 
                 down 
                 MUC1 
                 mucin 1, cell surface associated 
               
               
                 212882_at 
                 2.5058832 
                 down 
                 KLHL18 
                 kelch-like 18 ( Drosophila ) 
               
               
                 204653_at 
                 2.5022001 
                 down 
                 TFAP2A 
                 transcription factor AP-2 alpha 
               
               
                   
                   
                   
                   
                 (activating enhancer binding protein 2 
               
               
                   
                   
                   
                   
                 alpha) 
               
               
                 219518_s_at 
                 2.5002704 
                 down 
                 ELL3 
                 elongation factor RNA polymerase II- 
               
               
                   
                   
                   
                   
                 like 3 
               
               
                 201939_at 
                 2.4999027 
                 down 
                 PLK2 
                 polo-like kinase 2 ( Drosophila ) 
               
               
                 210582_s_at 
                 2.499334 
                 down 
                 LIMK2 
                 LIM domain kinase 2 
               
               
                 237252_at 
                 2.4946501 
                 down 
                 THBD 
                 thrombomodulin 
               
               
                 201349_at 
                 2.490851 
                 down 
                 SLC9A3R1 
                 solute carrier family 9 
               
               
                   
                   
                   
                   
                 (sodium/hydrogen exchanger), member 
               
               
                   
                   
                   
                   
                 3 regulator 1 
               
               
                 203216_s_at 
                 2.4889913 
                 down 
                 MYO6 
                 myosin VI 
               
               
                 213256_at 
                 2.4881077 
                 down 
                 39875 
                 membrane-associated ring finger 
               
               
                   
                   
                   
                   
                 (C3HC4) 3 
               
               
                 204989_s_at 
                 2.4878535 
                 down 
                 ITGB4 
                 integrin, beta 4 
               
               
                 213154_s_at 
                 2.484296 
                 down 
                 BICD2 
                 bicaudal D homolog 2 ( Drosophila ) 
               
               
                 214058_at 
                 2.4831367 
                 down 
                 MYCL1 
                 v-myc myelocytomatosis viral 
               
               
                   
                   
                   
                   
                 oncogene homolog 1, lung carcinoma 
               
               
                   
                   
                   
                   
                 derived (avian) 
               
               
                 220638_s_at 
                 2.4813514 
                 down 
                 CBLC 
                 Cas-Br-M (murine) ecotropic retroviral 
               
               
                   
                   
                   
                   
                 transforming sequence c 
               
               
                 218180_s_at 
                 2.4810977 
                 down 
                 EPS8L2 
                 EPS8-like 2 
               
               
                 235333_at 
                 2.480436 
                 down 
                 B4GALT6 
                 UDP-Gal:betaGlcNAc beta 1,4- 
               
               
                   
                   
                   
                   
                 galactosyltransferase, polypeptide 6 
               
               
                 203632_s_at 
                 2.4795673 
                 down 
                 GPRC5B 
                 G protein-coupled receptor, family C, 
               
               
                   
                   
                   
                   
                 group 5, member B 
               
               
                 229568_at 
                 2.4786081 
                 down 
                 MOBKL2B 
                 MOB1, Mps One Binder kinase 
               
               
                   
                   
                   
                   
                 activator-like 2B (yeast) 
               
               
                 206653_at 
                 2.4773498 
                 down 
                 POLR3G 
                 polymerase (RNA) III (DNA directed) 
               
               
                   
                   
                   
                   
                 polypeptide G (32 kD) 
               
               
                 201432_at 
                 2.4770842 
                 down 
                 CAT 
                 catalase 
               
               
                 224810_s_at 
                 2.4760013 
                 down 
                 ANKRD13A 
                 ankyrin repeat domain 13A 
               
               
                 1555942_a_at 
                 2.4756498 
                 down 
                 LOC642587 
                 CDNA FLJ33794 fis, clone 
               
               
                   
                   
                   
                   
                 CTONG1000009 
               
               
                 213726_x_at 
                 2.4728134 
                 down 
                 TUBB2C 
                 tubulin, beta 2C 
               
               
                 242197_x_at 
                 2.4713676 
                 down 
                 CD36 
                 CD36 antigen 
               
               
                 223394_at 
                 2.4701357 
                 down 
                 SERTAD1 
                 SERTA domain containing 1 
               
               
                 201641_at 
                 2.4696527 
                 down 
                 BST2 
                 bone marrow stromal cell antigen 2 
               
               
                 213288_at 
                 2.4695723 
                 down 
                 MBOAT2 
                 membrane bound O-acyltransferase 
               
               
                   
                   
                   
                   
                 domain containing 2 
               
               
                 221841_s_at 
                 2.467558 
                 down 
                 KLF4 
                 Kruppel-like factor 4 (gut) 
               
               
                 227970_at 
                 2.4662564 
                 down 
                 GPR157 
                 G protein-coupled receptor 157 
               
               
                 222996_s_at 
                 2.4653852 
                 down 
                 CXXC5 
                 CXXC finger 5 
               
               
                 209566_at 
                 2.4633334 
                 down 
                 INSIG2 
                 insulin induced gene 2 
               
               
                 214696_at 
                 2.4627934 
                 down 
                 C17orf91 
                 chromosome 17 open reading frame 91 
               
               
                 214234_s_at 
                 2.4618382 
                 down 
                 CYP3A5 
                 cytochrome P450, family 3, subfamily 
               
               
                   
                   
                   
                   
                 A, polypeptide 5 
               
               
                 223471_at 
                 2.4607677 
                 down 
                 RAB3IP 
                 RAB3A interacting protein (rabin3) 
               
               
                 234305_s_at 
                 2.4569333 
                 down 
                 GSDMC 
                 gasdermin C 
               
               
                 216388_s_at 
                 2.4562252 
                 down 
                 LTB4R 
                 leukotriene B4 receptor 
               
               
                 227624_at 
                 2.4547067 
                 down 
                 TET2 
                 tet oncogene family member 2 
               
               
                 223279_s_at 
                 2.453393 
                 down 
                 UACA 
                 uveal autoantigen with coiled-coil 
               
               
                   
                   
                   
                   
                 domains and ankyrin repeats 
               
               
                 40016_g_at 
                 2.452864 
                 down 
                 LOC100128443 
                 hypothetical protein LOC100128443 /// 
               
               
                   
                   
                   
                 /// MAST4 
                 microtubule associated 
               
               
                   
                   
                   
                   
                 serine/threonine kinase family member 4 
               
               
                 201341_at 
                 2.4487681 
                 down 
                 ENC1 
                 ectodermal-neural cortex (with BTB- 
               
               
                   
                   
                   
                   
                 like domain) 
               
               
                 242722_at 
                 2.4461777 
                 down 
                 LMO7 
                 LIM domain 7 
               
               
                 224301_x_at 
                 2.4447956 
                 down 
                 H2AFJ 
                 H2A histone family, member J 
               
               
                 225521_at 
                 2.4442914 
                 down 
                 ANAPC7 
                 anaphase promoting complex subunit 7 
               
               
                 206355_at 
                 2.442836 
                 down 
                 GNAL 
                 guanine nucleotide binding protein (G 
               
               
                   
                   
                   
                   
                 protein), alpha activating activity 
               
               
                   
                   
                   
                   
                 polypeptide, olfactory type 
               
               
                 219296_at 
                 2.4395428 
                 down 
                 ZDHHC13 
                 zinc finger, DHHC-type containing 13 
               
               
                 200752_s_at 
                 2.4395049 
                 down 
                 CAPN1 
                 calpain 1, (mu/I) large subunit 
               
               
                 209031_at 
                 2.4321353 
                 down 
                 CADM1 
                 cell adhesion molecule 1 
               
               
                 216641_s_at 
                 2.4319324 
                 down 
                 LAD1 
                 ladinin 1 
               
               
                 209758_s_at 
                 2.4311805 
                 down 
                 MFAP5 
                 microfibrillar associated protein 5 
               
               
                 228892_at 
                 2.4310536 
                 down 
                 SH3RF2 
                 SH3 domain containing ring finger 2 
               
               
                 223681_s_at 
                 2.4298599 
                 down 
                 INADL 
                 InaD-like ( Drosophila ) 
               
               
                 200768_s_at 
                 2.428787 
                 down 
                 MAT2A 
                 methionine adenosyltransferase II, 
               
               
                   
                   
                   
                   
                 alpha 
               
               
                 207455_at 
                 2.4276183 
                 down 
                 P2RY1 
                 purinergic receptor P2Y, G-protein 
               
               
                   
                   
                   
                   
                 coupled, 1 
               
               
                 220403_s_at 
                 2.4254568 
                 down 
                 P53AIP1 
                 p53-regulated apoptosis-inducing 
               
               
                   
                   
                   
                   
                 protein 1 
               
               
                 229800_at 
                 2.4252849 
                 down 
                 DCLK1 
                 KIAA0369 gene 
               
               
                 1555404_a_at 
                 2.4229205 
                 down 
                 DUOXA1 
                 dual oxidase maturation factor 1 
               
               
                 1558834_s_at 
                 2.4209795 
                 down 
                 C1orf62 
                 chromosome 1 open reading frame 62 
               
               
                 209291_at 
                 2.4183009 
                 down 
                 ID4 
                 inhibitor of DNA binding 4, dominant 
               
               
                   
                   
                   
                   
                 negative helix-loop-helix protein 
               
               
                 210831_s_at 
                 2.4178216 
                 down 
                 PTGER3 
                 prostaglandin E receptor 3 (subtype 
               
               
                   
                   
                   
                   
                 EP3) 
               
               
                 1559571_a_at 
                 2.4145973 
                 down 
                 ATP13A4 
                 ATPase type 13A4 
               
               
                 231928_at 
                 2.4141552 
                 down 
                 HES2 
                 hairy and enhancer of split 2 
               
               
                   
                   
                   
                   
                 ( Drosophila ) 
               
               
                 202005_at 
                 2.41391 
                 down 
                 ST14 
                 suppression of tumorigenicity 14 
               
               
                   
                   
                   
                   
                 (colon carcinoma) 
               
               
                 212406_s_at 
                 2.413782 
                 down 
                 PCMTD2 
                 protein-L-isoaspartate (D-aspartate) O- 
               
               
                   
                   
                   
                   
                 methyltransferase domain containing 2 
               
               
                 218826_at 
                 2.4101262 
                 down 
                 SLC35F2 
                 solute carrier family 35, member F2 
               
               
                 212707_s_at 
                 2.4100726 
                 down 
                 LOC100133005 
                 similar to RAS p21 protein activator 4 
               
               
                   
                   
                   
                 /// 
                 /// similar to HSPC047 protein /// RAS 
               
               
                   
                   
                   
                 LOC100134722 
                 p21 protein activator 4 /// RAS p21 
               
               
                   
                   
                   
                 /// RASA4 
                 protein activator 4 pseudogene 
               
               
                   
                   
                   
                 /// RASA4P 
               
               
                 208779_x_at 
                 2.4082775 
                 down 
                 DDR1 
                 discoidin domain receptor tyrosine 
               
               
                   
                   
                   
                   
                 kinase 1 
               
               
                 206873_at 
                 2.4066236 
                 down 
                 CA6 
                 carbonic anhydrase VI 
               
               
                 221750_at 
                 2.4064143 
                 down 
                 HMGCS1 
                 3-hydroxy-3-methylglutaryl-Coenzyme 
               
               
                   
                   
                   
                   
                 A synthase 1 (soluble) 
               
               
                 212321_at 
                 2.405509 
                 down 
                 SGPL1 
                 sphingosine-1-phosphate lyase 1 
               
               
                 201535_at 
                 2.4043798 
                 down 
                 UBL3 
                 ubiquitin-like 3 
               
               
                 231804_at 
                 2.4037292 
                 down 
                 RXFP1 
                 relaxin/insulin-like family peptide 
               
               
                   
                   
                   
                   
                 receptor 1 
               
               
                 200703_at 
                 2.4029148 
                 down 
                 DYNLL1 
                 dynein, light chain, LC8-type 1 
               
               
                 205968_at 
                 2.402016 
                 down 
                 KCNS3 
                 potassium voltage-gated channel, 
               
               
                   
                   
                   
                   
                 delayed-rectifier, subfamily S, member 3 
               
               
                 219856_at 
                 2.4011526 
                 down 
                 C1orf116 
                 chromosome 1 open reading frame 116 
               
               
                 217979_at 
                 2.400637 
                 down 
                 TSPAN13 
                 tetraspanin 13 
               
               
                 218739_at 
                 2.3995485 
                 down 
                 ABHD5 
                 abhydrolase domain containing 5 
               
               
                 33646_g_at 
                 2.3972998 
                 down 
                 GM2A 
                 GM2 ganglioside activator 
               
               
                 211071_s_at 
                 2.3966746 
                 down 
                 MLLT11 
                 myeloid/lymphoid or mixed-lineage 
               
               
                   
                   
                   
                   
                 leukemia (trithorax homolog, 
               
               
                   
                   
                   
                   
                   Drosophila ); translocated to, 11 
               
               
                 1569157_s_at 
                 2.3959668 
                 down 
                 ZNF846 
                 zinc finger protein 846 
               
               
                 222536_s_at 
                 2.3936675 
                 down 
                 ZNF395 
                 zinc finger protein 395 
               
               
                 213051_at 
                 2.39318 
                 down 
                 ZC3HAV1 
                 zinc finger CCCH-type, antiviral 1 
               
               
                 227335_at 
                 2.3928032 
                 down 
                 DIDO1 
                 death inducer-obliterator 1 
               
               
                 223265_at 
                 2.3924136 
                 down 
                 SH3BP5L 
                 SH3-binding domain protein 5-like 
               
               
                 218902_at 
                 2.390648 
                 down 
                 NOTCH1 
                 Notch homolog 1, translocation- 
               
               
                   
                   
                   
                   
                 associated ( Drosophila ) 
               
               
                 201975_at 
                 2.38955 
                 down 
                 CLIP1 
                 CAP-GLY domain containing linker 
               
               
                   
                   
                   
                   
                 protein 1 
               
               
                 203515_s_at 
                 2.388306 
                 down 
                 PMVK 
                 phosphomevalonate kinase 
               
               
                 202016_at 
                 2.3868265 
                 down 
                 MEST 
                 mesoderm specific transcript homolog 
               
               
                   
                   
                   
                   
                 (mouse) 
               
               
                 213280_at 
                 2.38649 
                 down 
                 GARNL4 
                 GTPase activating Rap/RanGAP 
               
               
                   
                   
                   
                   
                 domain-like 4 
               
               
                 209424_s_at 
                 2.381329 
                 down 
                 AMACR 
                 alpha-methylacyl-CoA racemase 
               
               
                 202720_at 
                 2.3791854 
                 down 
                 TES 
                 testis derived transcript (3 LIM 
               
               
                   
                   
                   
                   
                 domains) 
               
               
                 219272_at 
                 2.3777165 
                 down 
                 TRIM62 
                 tripartite motif-containing 62 
               
               
                 223454_at 
                 2.3772516 
                 down 
                 CXCL16 
                 chemokine (C—X—C motif) ligand 16 
               
               
                 205073_at 
                 2.3759983 
                 down 
                 CYP2J2 
                 cytochrome P450, family 2, subfamily 
               
               
                   
                   
                   
                   
                 J, polypeptide 2 
               
               
                 227263_at 
                 2.3751676 
                 down 
                 C8orf58 
                 chromosome 8 open reading frame 58 
               
               
                 227725_at 
                 2.3737078 
                 down 
                 ST6GALNAC1 
                 ST6 (alpha-N-acetyl-neuraminyl-2,3- 
               
               
                   
                   
                   
                   
                 beta-galactosyl-1,3)-N- 
               
               
                   
                   
                   
                   
                 acetylgalactosaminide alpha-2,6- 
               
               
                   
                   
                   
                   
                 sialyltransferase 1 
               
               
                 212830_at 
                 2.3727896 
                 down 
                 MEGF9 
                 multiple EGF-like-domains 9 
               
               
                 201733_at 
                 2.3707964 
                 down 
                 CLCN3 
                 chloride channel 3 
               
               
                 224836_at 
                 2.368579 
                 down 
                 TP53INP2 
                 tumor protein p53 inducible nuclear 
               
               
                   
                   
                   
                   
                 protein 2 
               
               
                 213562_s_at 
                 2.367167 
                 down 
                 SQLE 
                 squalene epoxidase 
               
               
                 230076_at 
                 2.3642602 
                 down 
                 PITPNM3 
                 PITPNM family member 3 
               
               
                 227880_s_at 
                 2.363816 
                 down 
                 LOC100132969 
                 hypothetical protein LOC100132969 /// 
               
               
                   
                   
                   
                 /// 
                 transmembrane protein 185A 
               
               
                   
                   
                   
                 TMEM185A 
               
               
                 226980_at 
                 2.362776 
                 down 
                 DEPDC1B 
                 DEP domain containing 1B 
               
               
                 224622_at 
                 2.3615942 
                 down 
                 TBC1D14 
                 TBC1 domain family, member 14 
               
               
                 231861_at 
                 2.3615434 
                 down 
                 LRP10 
                 low density lipoprotein receptor-related 
               
               
                   
                   
                   
                   
                 protein 10 
               
               
                 230864_at 
                 2.3605864 
                 down 
                 MGC42105 
                 serine/threonine-protein kinase NIM1 
               
               
                 227868_at 
                 2.3588343 
                 down 
                 LOC154761 
                 hypothetical LOC154761 
               
               
                 228647_at 
                 2.357218 
                 down 
                 LOC100049716 
                 hypothetical protein LOC100049716 
               
               
                 223289_s_at 
                 2.356582 
                 down 
                 USP38 
                 ubiquitin specific peptidase 38 
               
               
                 218816_at 
                 2.3564343 
                 down 
                 LRRC1 
                 leucine rich repeat containing 1 
               
               
                 235068_at 
                 2.355547 
                 down 
                 ZDHHC21 
                 zinc finger, DHHC-type containing 21 
               
               
                 212861_at 
                 2.3544407 
                 down 
                 MFSD5 
                 major facilitator superfamily domain 
               
               
                   
                   
                   
                   
                 containing 5 
               
               
                 227404_s_at 
                 2.3532495 
                 down 
                 EGR1 
                 Putative zinc finger protein mRNA, 3′ 
               
               
                   
                   
                   
                   
                 flank 
               
               
                 202669_s_at 
                 2.3530884 
                 down 
                 EFNB2 
                 ephrin-B2 
               
               
                 202506_at 
                 2.3506389 
                 down 
                 SSFA2 
                 sperm specific antigen 2 
               
               
                 228123_s_at 
                 2.3497157 
                 down 
                 ABHD12 
                 abhydrolase domain containing 12 
               
               
                 239598_s_at 
                 2.3495939 
                 down 
                 LPCAT2 
                 lysophosphatidylcholine 
               
               
                   
                   
                   
                   
                 acyltransferase 2 
               
               
                 201734_at 
                 2.3489254 
                 down 
                 CLCN3 
                 Chloride channel protein 3 (CLCN3) 
               
               
                 220599_s_at 
                 2.3469906 
                 down 
                 CARD14 
                 caspase recruitment domain family, 
               
               
                   
                   
                   
                   
                 member 14 
               
               
                 202341_s_at 
                 2.346867 
                 down 
                 TRIM2 
                 tripartite motif-containing 2 
               
               
                 225099_at 
                 2.3461185 
                 down 
                 FBXO45 
                 F-box protein 45 
               
               
                 225634_at 
                 2.3442137 
                 down 
                 ZC3HAV1 
                 zinc finger CCCH-type, antiviral 1 
               
               
                 204675_at 
                 2.341739 
                 down 
                 SRD5A1 
                 steroid-5-alpha-reductase, alpha 
               
               
                   
                   
                   
                   
                 polypeptide 1 (3-oxo-5 alpha-steroid 
               
               
                   
                   
                   
                   
                 delta 4-dehydrogenase alpha 1) 
               
               
                 222774_s_at 
                 2.3412967 
                 down 
                 NETO2 
                 neuropilin (NRP) and tolloid (TLL)- 
               
               
                   
                   
                   
                   
                 like 2 
               
               
                 207708_at 
                 2.3381183 
                 down 
                 ALOXE3 
                 arachidonate lipoxygenase 3 
               
               
                 226599_at 
                 2.3369987 
                 down 
                 FHDC1 
                 FH2 domain containing 1 
               
               
                 235475_at 
                 2.3346572 
                 down 
                 LOC100129720 
                 CDNA clone IMAGE: 5302722 
               
               
                 231211_s_at 
                 2.333402 
                 down 
                 LOC541469 
                 hypothetical protein LOC541469 
               
               
                 202950_at 
                 2.3329318 
                 down 
                 CRYZ 
                 crystallin, zeta (quinone reductase) 
               
               
                 223340_at 
                 2.3317142 
                 down 
                 ATL1 
                 atlastin GTPase 1 
               
               
                 236207_at 
                 2.3308241 
                 down 
                 SSFA2 
                 sperm specific antigen 2 
               
               
                 225245_x_at 
                 2.328221 
                 down 
                 H2AFJ 
                 H2A histone family, member J 
               
               
                 1554122_a_at 
                 2.3248432 
                 down 
                 HSD17B12 
                 hydroxysteroid (17-beta) 
               
               
                   
                   
                   
                   
                 dehydrogenase 12 
               
               
                 222853_at 
                 2.3233314 
                 down 
                 FLRT3 
                 fibronectin leucine rich transmembrane 
               
               
                   
                   
                   
                   
                 protein 3 
               
               
                 227163_at 
                 2.3232682 
                 down 
                 GSTO2 
                 glutathione S-transferase omega 2 
               
               
                 205774_at 
                 2.317882 
                 down 
                 F12 
                 coagulation factor XII (Hageman 
               
               
                   
                   
                   
                   
                 factor) 
               
               
                 45288_at 
                 2.317875 
                 down 
                 ABHD6 /// 
                 abhydrolase domain containing 6 /// 
               
               
                   
                   
                   
                 LOC643635 
                 similar to DEAD/H (Asp-Glu-Ala- 
               
               
                   
                   
                   
                   
                 Asp/His) box polypeptide 11 
               
               
                 201371_s_at 
                 2.3138196 
                 down 
                 CUL3 
                 cullin 3 
               
               
                 214355_x_at 
                 2.3121972 
                 down 
                 CTAGE4 /// 
                 CTAGE family, member 4 /// CTAGE 
               
               
                   
                   
                   
                 LOC100142659 
                 family member /// similar to CTAGE6 
               
               
                   
                   
                   
                 /// 
               
               
                   
                   
                   
                 LOC441294 
               
               
                 235987_at 
                 2.3110762 
                 down 
                 PRKXP1 
                 protein kinase, X-linked, pseudogene 1 
               
               
                 200813_s_at 
                 2.3108816 
                 down 
                 PAFAH1B1 
                 platelet-activating factor 
               
               
                   
                   
                   
                   
                 acetylhydrolase, isoform Ib, alpha 
               
               
                   
                   
                   
                   
                 subunit 45 kDa 
               
               
                 214651_s_at 
                 2.3090641 
                 down 
                 HOXA9 
                 homeobox A9 
               
               
                 201790_s_at 
                 2.3061028 
                 down 
                 DHCR7 
                 7-dehydrocholesterol reductase 
               
               
                 1557458_s_at 
                 2.3032465 
                 down 
                 SHB 
                 Src homology 2 domain containing 
               
               
                   
                   
                   
                   
                 adaptor protein B 
               
               
                 202748_at 
                 2.302949 
                 down 
                 GBP2 
                 guanylate binding protein 2, interferon- 
               
               
                   
                   
                   
                   
                 inducible 
               
               
                 229492_at 
                 2.300059 
                 down 
                 VANGL1 
                 vang-like 1 (van gogh,  Drosophila ) 
               
               
                 225108_at 
                 2.2977571 
                 down 
                 AGPS 
                 alkylglycerone phosphate synthase 
               
               
                 238638_at 
                 2.2977488 
                 down 
                 SLC37A2 
                 solute carrier family 37 (glycerol-3- 
               
               
                   
                   
                   
                   
                 phosphate transporter), member 2 
               
               
                 223594_at 
                 2.294716 
                 down 
                 TMEM117 
                 transmembrane protein 117 
               
               
                 225973_at 
                 2.294342 
                 down 
                 TAP2 
                 transporter 2, ATP-binding cassette, 
               
               
                   
                   
                   
                   
                 sub-family B (MDR/TAP) 
               
               
                 217118_s_at 
                 2.2925084 
                 down 
                 C22orf9 
                 chromosome 22 open reading frame 9 
               
               
                 210383_at 
                 2.2922642 
                 down 
                 SCN1A 
                 sodium channel, voltage-gated, type I, 
               
               
                   
                   
                   
                   
                 alpha subunit 
               
               
                 208866_at 
                 2.291897 
                 down 
                 CSNK1A1 
                 casein kinase 1, alpha 1 
               
               
                 223349_s_at 
                 2.2913735 
                 down 
                 BOK 
                 BCL2-related ovarian killer 
               
               
                 207911_s_at 
                 2.287757 
                 down 
                 TGM5 
                 transglutaminase 5 
               
               
                 212989_at 
                 2.2870367 
                 down 
                 SGMS1 
                 sphingomyelin synthase 1 
               
               
                 225517_at 
                 2.2865238 
                 down 
                 ZNF770 
                 zinc finger protein 770 
               
               
                 235606_at 
                 2.2857234 
                 down 
                 LOC344595 
                 hypothetical LOC344595 
               
               
                 214235_at 
                 2.285186 
                 down 
                 CYP3A5 
                 cytochrome P450, family 3, subfamily 
               
               
                   
                   
                   
                   
                 A, polypeptide 5 
               
               
                 213430_at 
                 2.283703 
                 down 
                 RUFY3 
                 RUN and FYVE domain containing 3 
               
               
                 219528_s_at 
                 2.2819934 
                 down 
                 BCL11B 
                 B-cell CLL/lymphoma 11B (zinc 
               
               
                   
                   
                   
                   
                 finger protein) 
               
               
                 1563805_a_at 
                 2.281725 
                 down 
                 FAM83C 
                 family with sequence similarity 83, 
               
               
                   
                   
                   
                   
                 member C 
               
               
                 213546_at 
                 2.276899 
                 down 
                 DKFZP586I1420 
                 hypothetical protein DKFZp586I1420 
               
               
                 206263_at 
                 2.274217 
                 down 
                 FMO4 
                 flavin containing monooxygenase 4 
               
               
                 225954_s_at 
                 2.2734365 
                 down 
                 MIDN 
                 midnolin 
               
               
                 215103_at 
                 2.2728736 
                 down 
                 CYP2C18 
                 cytochrome P450, family 2, subfamily 
               
               
                   
                   
                   
                   
                 C, polypeptide 18 
               
               
                 227228_s_at 
                 2.2723181 
                 down 
                 CCDC88C 
                 coiled-coil domain containing 88C 
               
               
                 220318_at 
                 2.2720828 
                 down 
                 EPN3 
                 epsin 3 
               
               
                 227981_at 
                 2.271106 
                 down 
                 CYB561D1 
                 cytochrome b-561 domain containing 1 
               
               
                 202562_s_at 
                 2.269635 
                 down 
                 C14orf1 
                 chromosome 14 open reading frame 1 
               
               
                 202788_at 
                 2.269064 
                 down 
                 MAPKAPK3 
                 mitogen-activated protein kinase- 
               
               
                   
                   
                   
                   
                 activated protein kinase 3 
               
               
                 231166_at 
                 2.2656186 
                 down 
                 GPR155 
                 G protein-coupled receptor 155 
               
               
                 1555716_a_at 
                 2.2642384 
                 down 
                 CXADR 
                 coxsackie virus and adenovirus 
               
               
                   
                   
                   
                   
                 receptor 
               
               
                 220966_x_at 
                 2.2637703 
                 down 
                 ARPC5L 
                 actin related protein 2/3 complex, 
               
               
                   
                   
                   
                   
                 subunit 5-like 
               
               
                 232034_at 
                 2.2627313 
                 down 
                 LOC203274 
                 CDNA FLJ31544 fis, clone 
               
               
                   
                   
                   
                   
                 NT2RI2000865 
               
               
                 226021_at 
                 2.2623584 
                 down 
                 RDH10 
                 retinol dehydrogenase 10 (all-trans) 
               
               
                 209608_s_at 
                 2.2597988 
                 down 
                 ACAT2 
                 acetyl-Coenzyme A acetyltransferase 2 
               
               
                 212978_at 
                 2.2586613 
                 down 
                 LRRC8B 
                 leucine rich repeat containing 8 family, 
               
               
                   
                   
                   
                   
                 member B 
               
               
                 223288_at 
                 2.2585614 
                 down 
                 USP38 
                 ubiquitin specific peptidase 38 
               
               
                 1555905_a_at 
                 2.2584996 
                 down 
                 C3orf23 
                 chromosome 3 open reading frame 23 
               
               
                 205109_s_at 
                 2.2583284 
                 down 
                 ARHGEF4 
                 Rho guanine nucleotide exchange 
               
               
                   
                   
                   
                   
                 factor (GEF) 4 
               
               
                 204465_s_at 
                 2.2553155 
                 down 
                 INA 
                 internexin neuronal intermediate 
               
               
                   
                   
                   
                   
                 filament protein, alpha 
               
               
                 209679_s_at 
                 2.2552056 
                 down 
                 LOC57228 
                 small trans-membrane and 
               
               
                   
                   
                   
                   
                 glycosylated protein 
               
               
                 217856_at 
                 2.2544947 
                 down 
                 RBM8A 
                 RNA binding motif protein 8A 
               
               
                 218261_at 
                 2.253576 
                 down 
                 AP1M2 
                 adaptor-related protein complex 1, mu 
               
               
                   
                   
                   
                   
                 2 subunit 
               
               
                 231990_at 
                 2.251771 
                 down 
                 USP15 
                 ubiquitin specific peptidase 15 
               
               
                 210933_s_at 
                 2.2504241 
                 down 
                 FSCN1 
                 fascin homolog 1, actin-bundling 
               
               
                   
                   
                   
                   
                 protein (Strongylocentrotus 
               
               
                   
                   
                   
                   
                 purpuratus) 
               
               
                 209872_s_at 
                 2.249547 
                 down 
                 PKP3 
                 plakophilin 3 
               
               
                 205602_x_at 
                 2.2482867 
                 down 
                 PSG7 
                 pregnancy specific beta-1-glycoprotein 7 
               
               
                 228851_s_at 
                 2.2482166 
                 down 
                 ENSA 
                 endosulfine alpha 
               
               
                 238846_at 
                 2.2471364 
                 down 
                 TNFRSF11A 
                 tumor necrosis factor receptor 
               
               
                   
                   
                   
                   
                 superfamily, member 11a, NFKB 
               
               
                   
                   
                   
                   
                 activator 
               
               
                 1553059_at 
                 22462165 
                 down 
                 PGLYRP3 
                 peptidoglycan recognition protein 3 
               
               
                 215513_at 
                 2.2452734 
                 down 
                 HYMAI 
                 hydatidiform mole associated and 
               
               
                   
                   
                   
                   
                 imprinted (non-protein coding) 
               
               
                 231062_at 
                 2.2450545 
                 down 
                 LOC100129122 
                 Clone IMAGE: 1257951, mRNA 
               
               
                   
                   
                   
                   
                 sequence 
               
               
                 204761_at 
                 2.244495 
                 down 
                 USP6NL 
                 USP6 N-terminal like 
               
               
                 219517_at 
                 2.2439237 
                 down 
                 ELL3 
                 elongation factor RNA polymerase II- 
               
               
                   
                   
                   
                   
                 like 3 
               
               
                 201791_s_at 
                 2.242235 
                 down 
                 DHCR7 
                 7-dehydrocholesterol reductase 
               
               
                 210058_at 
                 2.2416518 
                 down 
                 MAPK13 
                 mitogen-activated protein kinase 13 
               
               
                 225342_at 
                 2.2410355 
                 down 
                 AK3L1 /// 
                 adenylate kinase 3-like 1 /// adenylate 
               
               
                   
                   
                   
                 AK3L2 
                 kinase 3-like 2 
               
               
                 210059_s_at 
                 2.2387981 
                 down 
                 MAPK13 
                 mitogen-activated protein kinase 13 
               
               
                 206149_at 
                 2.236605 
                 down 
                 CHP2 
                 calcineurin B homologous protein 2 
               
               
                 201566_x_at 
                 2.2364604 
                 down 
                 ID2 
                 inhibitor of DNA binding 2, dominant 
               
               
                   
                   
                   
                   
                 negative helix-loop-helix protein 
               
               
                 223101_s_at 
                 2.2357152 
                 down 
                 ARPC5L 
                 actin related protein 2/3 complex, 
               
               
                   
                   
                   
                   
                 subunit 5-like 
               
               
                 209905_at 
                 2.2349339 
                 down 
                 HOXA9 
                 homeobox A9 
               
               
                 227383_at 
                 2.2334142 
                 down 
                 LOC727820 
                 hypothetical protein LOC727820 
               
               
                 219330_at 
                 2.2328598 
                 down 
                 VANGL1 
                 vang-like 1 (van gogh,  Drosophila ) 
               
               
                 232103_at 
                 2.229358 
                 down 
                 BPNT1 
                 3′(2′), 5′-bisphosphate nucleotidase 1 
               
               
                 225300_at 
                 2.2289581 
                 down 
                 C15orf23 
                 chromosome 15 open reading frame 23 
               
               
                 229596_at 
                 2.2280157 
                 down 
                 AMDHD1 
                 amidohydrolase domain containing 1 
               
               
                 232138_at 
                 2.2262597 
                 down 
                 MBNL2 
                 Muscleblind-like 2 ( Drosophila ), 
               
               
                   
                   
                   
                   
                 mRNA (cDNA clone 
               
               
                   
                   
                   
                   
                 IMAGE: 4157895) 
               
               
                 207236_at 
                 2.2259998 
                 down 
                 ZNF345 
                 zinc finger protein 345 
               
               
                 227224_at 
                 2.2250893 
                 down 
                 RALGPS2 
                 Ral GEF with PH domain and SH3 
               
               
                   
                   
                   
                   
                 binding motif 2 
               
               
                 221896_s_at 
                 2.224972 
                 down 
                 HIGD1A 
                 HIG1 domain family, member 1A 
               
               
                 200637_s_at 
                 2.2237906 
                 down 
                 PTPRF 
                 protein tyrosine phosphatase, receptor 
               
               
                   
                   
                   
                   
                 type, F 
               
               
                 214798_at 
                 2.2234876 
                 down 
                 ATP2C2 
                 ATPase, Ca++ transporting, type 2C, 
               
               
                   
                   
                   
                   
                 member 2 
               
               
                 226915_s_at 
                 2.223121 
                 down 
                 ARPC5L 
                 actin related protein 2/3 complex, 
               
               
                   
                   
                   
                   
                 subunit 5-like 
               
               
                 213533 at 
                 2.219701 
                 down 
                 D4S234E 
                 DNA segment on chromosome 4 
               
               
                   
                   
                   
                   
                 (unique) 234 expressed sequence 
               
               
                 213577_at 
                 2.218055 
                 down 
                 SQLE 
                 squalene epoxidase 
               
               
                 219956_at 
                 2.2179477 
                 down 
                 GALNT6 
                 UDP-N-acetyl-alpha-D- 
               
               
                   
                   
                   
                   
                 galactosamine:polypeptide N- 
               
               
                   
                   
                   
                   
                 acetylgalactosaminyltransferase 6 
               
               
                   
                   
                   
                   
                 (GalNAc-T6) 
               
               
                 200632_s_at 
                 2.2170808 
                 down 
                 NDRG1 
                 N-myc downstream regulated 1 
               
               
                 202488_s_at 
                 2.2170005 
                 down 
                 FXYD3 
                 FXYD domain containing ion transport 
               
               
                   
                   
                   
                   
                 regulator 3 
               
               
                 202967_at 
                 2.2159603 
                 down 
                 GSTA4 
                 glutathione S-transferase alpha 4 
               
               
                 209727_at 
                 2.2159023 
                 down 
                 GM2A 
                 GM2 ganglioside activator 
               
               
                 203081_at 
                 2.2149336 
                 down 
                 CTNNBIP1 
                 catenin, beta interacting protein 1 
               
               
                 1555416_a_at 
                 2.214861 
                 down 
                 ALOX15B 
                 arachidonate 15-lipoxygenase, type B 
               
               
                 236725_at 
                 2.2132413 
                 down 
                 WWC1 
                 WW and C2 domain containing 1 
               
               
                 225726_s_at 
                 2.213236 
                 down 
                 PLEKHH1 
                 pleckstrin homology domain 
               
               
                   
                   
                   
                   
                 containing, family H (with MyTH4 
               
               
                   
                   
                   
                   
                 domain) member 1 
               
               
                 203625_x_at 
                 2.21156 
                 down 
                 SKP2 
                 CDNA: FLJ22571 fis, clone HSI02239 
               
               
                 206417_at 
                 2.211349 
                 down 
                 CNGA1 
                 cyclic nucleotide gated channel alpha 1 
               
               
                 207602_at 
                 2.2072852 
                 down 
                 TMPRSS11D 
                 transmembrane protease, serine 11D 
               
               
                 202951_at 
                 2.2066703 
                 down 
                 STK38 
                 serine/threonine kinase 38 
               
               
                 220985_s_at 
                 2.2064672 
                 down 
                 RNF170 
                 ring finger protein 170 
               
               
                 205092_x_at 
                 2.2053156 
                 down 
                 ZBTB1 
                 zinc finger and BTB domain 
               
               
                   
                   
                   
                   
                 containing 1 
               
               
                 226844_at 
                 2.2050638 
                 down 
                 MOBKL2B 
                 MOB1, Mps One Binder kinase 
               
               
                   
                   
                   
                   
                 activator-like 2B (yeast) 
               
               
                 226448_at 
                 2.2045517 
                 down 
                 FAM89A 
                 family with sequence similarity 89, 
               
               
                   
                   
                   
                   
                 member A 
               
               
                 227997_at 
                 2.2044806 
                 down 
                 IL17RD 
                 interleukin 17 receptor D 
               
               
                 220225_at 
                 2.203769 
                 down 
                 IRX4 
                 iroquois homeobox 4 
               
               
                 40524_at 
                 2.2021623 
                 down 
                 PTPN21 
                 protein tyrosine phosphatase, non- 
               
               
                   
                   
                   
                   
                 receptor type 21 
               
               
                 202725_at 
                 2.199355 
                 down 
                 POLR2A 
                 polymerase (RNA) II (DNA directed) 
               
               
                   
                   
                   
                   
                 polypeptide A, 220 kDa 
               
               
                 207065_at 
                 2.198705 
                 down 
                 KRT75 
                 keratin 75 
               
               
                 224746_at 
                 2.1967638 
                 down 
                 KIAA1522 
                 KIAA1522 
               
               
                 202330_s_at 
                 2.196532 
                 down 
                 UNG 
                 uracil-DNA glycosylase 
               
               
                 201735_s_at 
                 2.1951425 
                 down 
                 CLCN3 
                 chloride channel 3 
               
               
                 212848_s_at 
                 2.1947465 
                 down 
                 C9orf3 
                 chromosome 9 open reading frame 3 
               
               
                 209389_x_at 
                 2.194297 
                 down 
                 DBI 
                 diazepam binding inhibitor (GABA 
               
               
                   
                   
                   
                   
                 receptor modulator, acyl-Coenzyme A 
               
               
                   
                   
                   
                   
                 binding protein) 
               
               
                 217188_s_at 
                 2.19428 
                 down 
                 C14orf1 
                 chromosome 14 open reading frame 1 
               
               
                 232843_s_at 
                 2.193926 
                 down 
                 DOCK8 
                 dedicator of cytokinesis 8 
               
               
                 210749_x_at 
                 2.1906087 
                 down 
                 DDR1 
                 discoidin domain receptor tyrosine 
               
               
                   
                   
                   
                   
                 kinase 1 
               
               
                 1569385_s_at 
                 2.1899562 
                 down 
                 TET2 
                 tet oncogene family member 2 
               
               
                 218640_s_at 
                 2.1887794 
                 down 
                 PLEKHF2 
                 pleckstrin homology domain 
               
               
                   
                   
                   
                   
                 containing, family F (with FYVE 
               
               
                   
                   
                   
                   
                 domain) member 2 
               
               
                 205535_s_at 
                 2.1884425 
                 down 
                 PCDH7 
                 protocadherin 7 
               
               
                 203395_s_at 
                 2.1880076 
                 down 
                 HES1 
                 hairy and enhancer of split 1, 
               
               
                   
                   
                   
                   
                 ( Drosophila ) 
               
               
                 225927_at 
                 2.1876142 
                 down 
                 MAP3K1 
                 mitogen-activated protein kinase 
               
               
                   
                   
                   
                   
                 kinase kinase 1 
               
               
                 44120_at 
                 2.1861672 
                 down 
                 ADCK2 
                 aarF domain containing kinase 2 
               
               
                 225367_at 
                 2.1861136 
                 down 
                 PGM2 
                 phosphoglucomutase 2 
               
               
                 202178_at 
                 2.1859634 
                 down 
                 PRKCZ 
                 protein kinase C, zeta 
               
               
                 205964_at 
                 2.1812165 
                 down 
                 ZNF426 
                 zinc finger protein 426 
               
               
                 224799_at 
                 2.1811337 
                 down 
                 NDFIP2 
                 Nedd4 family interacting protein 2 
               
               
                 209163_at 
                 2.1807954 
                 down 
                 CYB561 
                 cytochrome b-561 
               
               
                 228762_at 
                 2.1806395 
                 down 
                 LFNG 
                 LFNG O-fucosylpeptide 3-beta-N- 
               
               
                   
                   
                   
                   
                 acetylglucosaminyltransferase 
               
               
                 214786_at 
                 2.180576 
                 down 
                 MAP3K1 
                 mitogen-activated protein kinase 
               
               
                   
                   
                   
                   
                 kinase kinase 1 
               
               
                 239693_at 
                 2.1804395 
                 down 
                 SNX24 
                 Sorting nexin SNX24 (SNX24) 
               
               
                 225100_at 
                 2.176683 
                 down 
                 FBXO45 
                 F-box protein 45 
               
               
                 212175_s_at 
                 2.1766407 
                 down 
                 AK2 
                 adenylate kinase 2 
               
               
                 217744_s_at 
                 2.1757214 
                 down 
                 PERP 
                 PERP, TP53 apoptosis effector 
               
               
                 212831_at 
                 2.1755953 
                 down 
                 MEGF9 
                 multiple EGF-like-domains 9 
               
               
                 223075_s_at 
                 2.168681 
                 down 
                 AIF1L 
                 allograft inflammatory factor 1-like 
               
               
                 216699_s_at 
                 2.168667 
                 down 
                 KLK1 
                 kallikrein 1 
               
               
                 244546_at 
                 2.1682029 
                 down 
                 CYCS 
                 cytochrome c, somatic 
               
               
                 213365_at 
                 2.1674378 
                 down 
                 ERI2 
                 exoribonuclease 2 
               
               
                 201215_at 
                 2.1666453 
                 down 
                 PLS3 
                 plastin 3 (T isoform) 
               
               
                 203881_s_at 
                 2.165027 
                 down 
                 DMD 
                 dystrophin 
               
               
                 208854_s_at 
                 2.1649718 
                 down 
                 STK24 
                 serine/threonine kinase 24 (STE20 
               
               
                   
                   
                   
                   
                 homolog, yeast) 
               
               
                 212944_at 
                 2.1649513 
                 down 
                 SLC5A3 
                 solute carrier family 5 (sodium/myo- 
               
               
                   
                   
                   
                   
                 inositol cotransporter), member 3 
               
               
                 205416_s_at 
                 2.1644816 
                 down 
                 ATXN3 
                 ataxin 3 
               
               
                 228378_at 
                 2.164461 
                 down 
                 C12orf29 
                 chromosome 12 open reading frame 29 
               
               
                 219229_at 
                 2.1620889 
                 down 
                 SLCO3A1 
                 solute carrier organic anion transporter 
               
               
                   
                   
                   
                   
                 family, member 3A1 
               
               
                 218657_at 
                 2.1619468 
                 down 
                 RAPGEFL1 
                 Rap guanine nucleotide exchange 
               
               
                   
                   
                   
                   
                 factor (GEF)-like 1 
               
               
                 204005_s_at 
                 2.161023 
                 down 
                 PAWR 
                 PRKC, apoptosis, WT1, regulator 
               
               
                 208345_s_at 
                 2.1601677 
                 down 
                 POU3F1 
                 POU class 3 homeobox 1 
               
               
                 209733_at 
                 2.160098 
                 down 
                 LOC286440 
                 hypothetical protein LOC286440 
               
               
                 225136_at 
                 2.1593971 
                 down 
                 PLEKHA2 
                 pleckstrin homology domain 
               
               
                   
                   
                   
                   
                 containing, family A (phosphoinositide 
               
               
                   
                   
                   
                   
                 binding specific) member 2 
               
               
                 201565_s_at 
                 2.1581004 
                 down 
                 ID2 
                 inhibitor of DNA binding 2, dominant 
               
               
                   
                   
                   
                   
                 negative helix-loop-helix protein 
               
               
                 235148_at 
                 2.1576118 
                 down 
                 KRTCAP3 
                 keratinocyte associated protein 3 
               
               
                 201820_at 
                 2.1536007 
                 down 
                 KRT5 
                 keratin 5 
               
               
                 226269_at 
                 2.1534703 
                 down 
                 GDAP1 
                 ganglioside-induced differentiation- 
               
               
                   
                   
                   
                   
                 associated protein 1 
               
               
                 218705_s_at 
                 2.1520202 
                 down 
                 SNX24 
                 sorting nexin 24 
               
               
                 235896_s_at 
                 2.1518188 
                 down 
                 SMCR7 
                 Smith-Magenis syndrome chromosome 
               
               
                   
                   
                   
                   
                 region, candidate 7 
               
               
                 1559078_at 
                 2.1510541 
                 down 
                 BCL11A 
                 CDNA FLJ58516 complete cds, highly 
               
               
                   
                   
                   
                   
                 similar to B-cell lymphoma/leukemia 
               
               
                   
                   
                   
                   
                 11A 
               
               
                 223214_s_at 
                 2.1498406 
                 down 
                 ZHX1 
                 zinc fingers and homeoboxes 1 
               
               
                 229515_at 
                 2.149676 
                 down 
                 PAWR 
                 CDNA clone IMAGE: 3892559 
               
               
                 209815_at 
                 2.14831 
                 down 
                 PTCH1 
                 patched homolog 1 ( Drosophila ) 
               
               
                 227478_at 
                 2.1481898 
                 down 
                 SETBP1 
                 SET binding protein 1 
               
               
                 238686_at 
                 2.1473422 
                 down 
                 FBXO3 
                 F-box protein 3 
               
               
                 202838_at 
                 2.1467884 
                 down 
                 FUCA1 
                 fucosidase, alpha-L-1, tissue 
               
               
                 209598_at 
                 2.1460617 
                 down 
                 PNMA2 
                 paraneoplastic antigen MA2 
               
               
                 214975_s_at 
                 2.1457093 
                 down 
                 MTMR1 
                 myotubularin related protein 1 
               
               
                 203276_at 
                 2.1456895 
                 down 
                 LMNB1 
                 lamin B1 
               
               
                 203431_s_at 
                 2.1429577 
                 down 
                 RICS 
                 Rho GTPase-activating protein 
               
               
                 1554445_at 
                 2.1428692 
                 down 
                 ZNF85 
                 zinc finger protein 85 
               
               
                 208051_s_at 
                 2.141477 
                 down 
                 PAIP1 
                 poly(A) binding protein interacting 
               
               
                   
                   
                   
                   
                 protein 1 
               
               
                 225282_at 
                 2.140211 
                 down 
                 SMAP2 
                 small ArfGAP2 
               
               
                 238451_at 
                 2.1400113 
                 down 
                 MPP7 
                 membrane protein, palmitoylated 7 
               
               
                   
                   
                   
                   
                 (MAGUK p55 subfamily member 7) 
               
               
                 201079_at 
                 2.1399426 
                 down 
                 SYNGR2 
                 synaptogyrin 2 
               
               
                 225878_at 
                 2.139625 
                 down 
                 KIF1B 
                 kinesin family member 1B 
               
               
                 213693_s_at 
                 2.138388 
                 down 
                 MUC1 
                 mucin 1, cell surface associated 
               
               
                 218421_at 
                 2.137857 
                 down 
                 CERK 
                 ceramide kinase 
               
               
                 219090_at 
                 2.1377168 
                 down 
                 SLC24A3 
                 solute carrier family 24 
               
               
                   
                   
                   
                   
                 (sodium/potassium/calcium 
               
               
                   
                   
                   
                   
                 exchanger), member 3 
               
               
                 226071_at 
                 2.1368642 
                 down 
                 ADAMTSL4 
                 ADAMTS-like 4 
               
               
                 219410_at 
                 2.1362329 
                 down 
                 TMEM45A 
                 transmembrane protein 45A 
               
               
                 235200_at 
                 2.1350272 
                 down 
                 ZNF561 
                 zinc finger protein 561 
               
               
                 219459_at 
                 2.1346684 
                 down 
                 POLR3B 
                 polymerase (RNA) III (DNA directed) 
               
               
                   
                   
                   
                   
                 polypeptide B 
               
               
                 225313_at 
                 2.1338372 
                 down 
                 C20orf177 
                 chromosome 20 open reading frame 
               
               
                   
                   
                   
                   
                 177 
               
               
                 243963_at 
                 2.133164 
                 down 
                 SDCCAG8 
                 Serologically defined colon cancer 
               
               
                   
                   
                   
                   
                 antigen 8, mRNA (cDNA clone 
               
               
                   
                   
                   
                   
                 IMAGE: 5301251) 
               
               
                 210958_s_at 
                 2.1311638 
                 down 
                 LOC100128443 
                 hypothetical protein LOC100128443 /// 
               
               
                   
                   
                   
                 /// MAST4 
                 microtubule associated 
               
               
                   
                   
                   
                   
                 serine/threonine kinase family member 4 
               
               
                 210609_s_at 
                 2.129718 
                 down 
                 TP53I3 
                 tumor protein p53 inducible protein 3 
               
               
                 209949_at 
                 2.1277685 
                 down 
                 NCF2 
                 neutrophil cytosolic factor 2 
               
               
                 224055_x_at 
                 2.1269937 
                 down 
                 KCNK7 
                 potassium channel, subfamily K, 
               
               
                   
                   
                   
                   
                 member 7 
               
               
                 232127_at 
                 2.1264925 
                 down 
                 CLCN5 
                 chloride channel 5 
               
               
                 223455_at 
                 2.126378 
                 down 
                 TCHP 
                 trichoplein, keratin filament binding 
               
               
                 209512_at 
                 2.1262662 
                 down 
                 HSDL2 
                 hydroxysteroid dehydrogenase like 2 
               
               
                 207206_s_at 
                 2.1244593 
                 down 
                 ALOX12 
                 arachidonate 12-lipoxygenase 
               
               
                 1558924_s_at 
                 2.1232033 
                 down 
                 CLIP1 
                 CAP-GLY domain containing linker 
               
               
                   
                   
                   
                   
                 protein 1 
               
               
                 216268_s_at 
                 2.1227787 
                 down 
                 JAG1 
                 jagged 1 (Alagille syndrome) 
               
               
                 215100_at 
                 2.1208134 
                 down 
                 C6orf105 
                 chromosome 6 open reading frame 105 
               
               
                 229685_at 
                 2.1203196 
                 down 
                 LOC100134937 
                 hypothetical LOC100134937 
               
               
                 202263_at 
                 2.1194017 
                 down 
                 CYB5R1 
                 cytochrome b5 reductase 1 
               
               
                 212136_at 
                 2.1178362 
                 down 
                 ATP2B4 
                 ATPase, Ca++ transporting, plasma 
               
               
                   
                   
                   
                   
                 membrane 4 
               
               
                 225308_s_at 
                 2.11776 
                 down 
                 TANC1 
                 tetratricopeptide repeat, ankyrin repeat 
               
               
                   
                   
                   
                   
                 and coiled-coil containing 1 
               
               
                 224865_at 
                 2.117143 
                 down 
                 FAR1 
                 fatty acyl CoA reductase 1 
               
               
                 228954_at 
                 2.1161342 
                 down 
                 LYSMD4 
                 LysM, putative peptidoglycan-binding, 
               
               
                   
                   
                   
                   
                 domain containing 4 
               
               
                 1563088_a_at 
                 2.1154768 
                 down 
                 LOC284837 
                 hypothetical protein LOC284837 
               
               
                 222849_s_at 
                 2.1153836 
                 down 
                 SCRN3 
                 secernin 3 
               
               
                 1568815_a_at 
                 2.1149223 
                 down 
                 DDX50 
                 DEAD (Asp-Glu-Ala-Asp) box 
               
               
                   
                   
                   
                   
                 polypeptide 50 
               
               
                 1554608_at 
                 2.1143405 
                 down 
                 TGOLN2 
                 trans-golgi network protein 2 
               
               
                 206857_s_at 
                 2.1133657 
                 down 
                 FKBP1B 
                 FK506 binding protein 1B, 12.6 kDa 
               
               
                 213764_s_at 
                 2.1121294 
                 down 
                 MFAP5 
                 microfibrillar associated protein 5 
               
               
                 218559_s_at 
                 2.1115992 
                 down 
                 MAFB 
                 v-maf musculoaponeurotic 
               
               
                   
                   
                   
                   
                 fibrosarcoma oncogene homolog B 
               
               
                   
                   
                   
                   
                 (avian) 
               
               
                 203609_s_at 
                 2.1106138 
                 down 
                 ALDH5A1 
                 aldehyde dehydrogenase 5 family, 
               
               
                   
                   
                   
                   
                 member A1 
               
               
                 214605_x_at 
                 2.1089497 
                 down 
                 GPR1 
                 G protein-coupled receptor 1 
               
               
                 203888_at 
                 2.1086705 
                 down 
                 THBD 
                 thrombomodulin 
               
               
                 215549_x_at 
                 2.1083808 
                 down 
                 CTAGE4 
                 CTAGE family, member 4 
               
               
                 241990_at 
                 2.1072762 
                 down 
                 RHOV 
                 ras homolog gene family, member V 
               
               
                 229955_at 
                 2.1066082 
                 down 
                 FBXO3 
                 F-box protein 3, mRNA (cDNA clone 
               
               
                   
                   
                   
                   
                 IMAGE: 5296662) 
               
               
                 222396_at 
                 2.10537 
                 down 
                 HN1 
                 hematological and neurological 
               
               
                   
                   
                   
                   
                 expressed 1 
               
               
                 211203_s_at 
                 2.1050365 
                 down 
                 CNTN1 
                 contactin 1 
               
               
                 209234_at 
                 2.104905 
                 down 
                 KIF1B 
                 kinesin family member 1B 
               
               
                 1007_s_at 
                 2.10379 
                 down 
                 DDR1 
                 discoidin domain receptor tyrosine 
               
               
                   
                   
                   
                   
                 kinase 1 
               
               
                 205909_at 
                 2.103594 
                 down 
                 POLE2 
                 polymerase (DNA directed), epsilon 2 
               
               
                   
                   
                   
                   
                 (p59 subunit) 
               
               
                 205248_at 
                 2.1027164 
                 down 
                 DOPEY2 
                 dopey family member 2 
               
               
                 229958_at 
                 2.102053 
                 down 
                 CLN8 
                 ceroid-lipofuscinosis, neuronal 8 
               
               
                   
                   
                   
                   
                 (epilepsy, progressive with mental 
               
               
                   
                   
                   
                   
                 retardation) 
               
               
                 222256_s_at 
                 2.1013858 
                 down 
                 JMJD7 /// 
                 jumonji domain containing 7 /// 
               
               
                   
                   
                   
                 JMJD7- 
                 JMJD7-PLA2G4B readthrough 
               
               
                   
                   
                   
                 PLA2G4B /// 
                 transcript /// phospholipase A2, group 
               
               
                   
                   
                   
                 PLA2G4B 
                 IVB (cytosolic) 
               
               
                 212089_at 
                 2.1000233 
                 down 
                 LMNA 
                 lamin A/C 
               
               
                 206429_at 
                 2.0988882 
                 down 
                 F2RL1 
                 coagulation factor II (thrombin) 
               
               
                   
                   
                   
                   
                 receptor-like 1 
               
               
                 1559094_at 
                 2.098726 
                 down 
                 FBXO9 
                 F-box protein 9 
               
               
                 238697_at 
                 2.0983906 
                 down 
                 NCRNA00086 
                 Hypothetical protein MGC39606, 
               
               
                   
                   
                   
                   
                 mRNA (cDNA clone MGC: 33489 
               
               
                   
                   
                   
                   
                 IMAGE: 4813443) 
               
               
                 222904_s_at 
                 2.096099 
                 down 
                 TMC5 
                 transmembrane channel-like 5 
               
               
                 225182_at 
                 2.0955298 
                 down 
                 TMEM50B 
                 transmembrane protein 50B 
               
               
                 203575_at 
                 2.0948935 
                 down 
                 CSNK2A2 
                 casein kinase 2, alpha prime 
               
               
                   
                   
                   
                   
                 polypeptide 
               
               
                 211922_s_at 
                 2.094567 
                 down 
                 CAT 
                 catalase 
               
               
                 1553982_a_at 
                 2.0945106 
                 down 
                 RAB7B 
                 RAB7B, member RAS oncogene 
               
               
                   
                   
                   
                   
                 family 
               
               
                 201839_s_at 
                 2.0932202 
                 down 
                 EPCAM 
                 epithelial cell adhesion molecule 
               
               
                 47560_at 
                 2.0923448 
                 down 
                 LPHN1 
                 latrophilin 1 
               
               
                 212186_at 
                 2.0908222 
                 down 
                 ACACA 
                 acetyl-Coenzyme A carboxylase alpha 
               
               
                 219187_at 
                 2.0901995 
                 down 
                 FKBPL 
                 FK506 binding protein like 
               
               
                 241946_at 
                 2.0896347 
                 down 
                 ZDHHC21 
                 zinc finger, DHHC-type containing 21 
               
               
                 1553021_s_at 
                 2.0895314 
                 down 
                 BICD2 
                 bicaudal D homolog 2 ( Drosophila ) 
               
               
                 203002_at 
                 2.0893335 
                 down 
                 AMOTL2 
                 angiomotin like 2 
               
               
                 203865_s_at 
                 2.08908 
                 down 
                 ADARB1 
                 adenosine deaminase, RNA-specific, 
               
               
                   
                   
                   
                   
                 B1 (RED1 homolog rat) 
               
               
                 200696_s_at 
                 2.0890284 
                 down 
                 GSN 
                 gelsolin (amyloidosis, Finnish type) 
               
               
                 204967_at 
                 2.0882254 
                 down 
                 SHROOM2 
                 shroom family member 2 
               
               
                 202894_at 
                 2.0872073 
                 down 
                 EPHB4 
                 EPH receptor B4 
               
               
                 1558292_s_at 
                 2.0845475 
                 down 
                 PIGW 
                 phosphatidylinositol glycan anchor 
               
               
                   
                   
                   
                   
                 biosynthesis, class W 
               
               
                 235567_at 
                 2.0833743 
                 down 
                 RORA 
                 Hypothetical protein LOC283666, 
               
               
                   
                   
                   
                   
                 mRNA (cDNA clone 
               
               
                   
                   
                   
                   
                 IMAGE: 4750925) 
               
               
                 212991_at 
                 2.0831015 
                 down 
                 FBXO9 
                 F-box protein 9 
               
               
                 216718_at 
                 2.0828507 
                 down 
                 C1orf46 
                 chromosome 1 open reading frame 46 
               
               
                 1558152_at 
                 2.081475 
                 down 
                 LOC100131262 
                 hypothetical LOC100131262 
               
               
                 225211_at 
                 2.08033 
                 down 
                 PVRL1 
                 poliovirus receptor-related 1 
               
               
                   
                   
                   
                   
                 (herpesvirus entry mediator C) 
               
               
                 202987_at 
                 2.0792933 
                 down 
                 TRAF3IP2 
                 TRAF3 interacting protein 2 
               
               
                 222236_s_at 
                 2.0789578 
                 down 
                 ASAP3 
                 ArfGAP with SH3 domain, ankyrin 
               
               
                   
                   
                   
                   
                 repeat and PH domain 3 
               
               
                 239230_at 
                 2.0784454 
                 down 
                 HES5 
                 hairy and enhancer of split 5 
               
               
                   
                   
                   
                   
                 ( Drosophila ) 
               
               
                 202501_at 
                 2.0782366 
                 down 
                 MAPRE2 
                 microtubule-associated protein, RP/EB 
               
               
                   
                   
                   
                   
                 family, member 2 
               
               
                 242255_at 
                 2.0781825 
                 down 
                 LOC100130837 
                 CDNA clone IMAGE: 4799914 
               
               
                 202587_s_at 
                 2.0776887 
                 down 
                 AK1 
                 adenylate kinase 1 
               
               
                 201032_at 
                 2.0772772 
                 down 
                 BLCAP 
                 bladder cancer associated protein 
               
               
                 202850_at 
                 2.076881 
                 down 
                 ABCD3 
                 ATP-binding cassette, sub-family D 
               
               
                   
                   
                   
                   
                 (ALD), member 3 
               
               
                 225618_at 
                 2.0766106 
                 down 
                 ARHGAP27 
                 Rho GTPase activating protein 27 
               
               
                 203666_at 
                 2.074363 
                 down 
                 CXCL12 
                 chemokine (C—X—C motif) ligand 12 
               
               
                   
                   
                   
                   
                 (stromal cell-derived factor 1) 
               
               
                 218148_at 
                 2.0743272 
                 down 
                 CENPT 
                 centromere protein T 
               
               
                 203777_s_at 
                 2.0739517 
                 down 
                 RPS6KB2 
                 ribosomal protein S6 kinase, 70 kDa, 
               
               
                   
                   
                   
                   
                 polypeptide 2 
               
               
                 226929_at 
                 2.0733016 
                 down 
                 MTHFR 
                 5,10-methylenetetrahydrofolate 
               
               
                   
                   
                   
                   
                 reductase (NADPH) 
               
               
                 225998_at 
                 2.0714586 
                 down 
                 GAB1 
                 GRB2-associated binding protein 1 
               
               
                 222843_at 
                 2.0714424 
                 down 
                 FIGNL1 
                 fidgetin-like 1 
               
               
                 225598_at 
                 2.0712779 
                 down 
                 SLC45A4 
                 solute carrier family 45, member 4 
               
               
                 223213_s_at 
                 2.0709321 
                 down 
                 ZHX1 
                 zinc fingers and homeoboxes 1 
               
               
                 39729_at 
                 2.0675848 
                 down 
                 PRDX2 
                 peroxiredoxin 2 
               
               
                 235174_s_at 
                 2.0673625 
                 down 
                 LOC100128822 
                 hypothetical protein LOC100128822 
               
               
                 219184_x_at 
                 2.0669382 
                 down 
                 TIMM22 
                 translocase of inner mitochondrial 
               
               
                   
                   
                   
                   
                 membrane 22 homolog (yeast) 
               
               
                 207023_x_at 
                 2.066204 
                 down 
                 KRT10 
                 keratin 10 
               
               
                 227739_at 
                 2.0635765 
                 down 
                 LOC648245 
                 hypothetical LOC648245 
               
               
                 218021_at 
                 2.0624394 
                 down 
                 DHRS4 /// 
                 dehydrogenase/reductase (SDR family) 
               
               
                   
                   
                   
                 DHRS4L2 
                 member 4 /// dehydrogenase/reductase 
               
               
                   
                   
                   
                   
                 (SDR family) member 4 like 2 
               
               
                 202342_s_at 
                 2.061941 
                 down 
                 TRIM2 
                 tripartite motif-containing 2 
               
               
                 203332_s_at 
                 2.060985 
                 down 
                 INPP5D 
                 inositol polyphosphate-5-phosphatase, 
               
               
                   
                   
                   
                   
                 145 kDa 
               
               
                 227255_at 
                 2.058867 
                 down 
                 PDIK1L 
                 PDLIM1 interacting kinase 1 like 
               
               
                 219968_at 
                 2.0585458 
                 down 
                 ZNF589 
                 zinc finger protein 589 
               
               
                 210045_at 
                 2.058517 
                 down 
                 IDH2 
                 isocitrate dehydrogenase 2 (NADP+), 
               
               
                   
                   
                   
                   
                 mitochondrial 
               
               
                 211070_x_at 
                 2.0563624 
                 down 
                 DBI 
                 diazepam binding inhibitor (GABA 
               
               
                   
                   
                   
                   
                 receptor modulator, acyl-Coenzyme A 
               
               
                   
                   
                   
                   
                 binding protein) 
               
               
                 200653_s_at 
                 2.0558417 
                 down 
                 CALM1 /// 
                 calmodulin 1 (phosphorylase kinase, 
               
               
                   
                   
                   
                 CALM2 /// 
                 delta) /// calmodulin 2 (phosphorylase 
               
               
                   
                   
                   
                 CALM3 
                 kinase, delta) /// calmodulin 3 
               
               
                   
                   
                   
                   
                 (phosphorylase kinase, delta) 
               
               
                 200884_at 
                 2.0550563 
                 down 
                 CKB 
                 creatine kinase, brain 
               
               
                 227384_s_at 
                 2.054656 
                 down 
                 LOC727820 
                 hypothetical protein LOC727820 
               
               
                 201409_s_at 
                 2.0540502 
                 down 
                 PPP1CB 
                 protein phosphatase 1, catalytic 
               
               
                   
                   
                   
                   
                 subunit, beta isoform 
               
               
                 205184_at 
                 2.0536096 
                 down 
                 GNG4 
                 guanine nucleotide binding protein (G 
               
               
                   
                   
                   
                   
                 protein), gamma 4 
               
               
                 1554600_s_at 
                 2.0529914 
                 down 
                 LMNA 
                 lamin A/C 
               
               
                 201474_s_at 
                 2.051571 
                 down 
                 ITGA3 
                 integrin, alpha 3 (antigen CD49C, 
               
               
                   
                   
                   
                   
                 alpha 3 subunit of VLA-3 receptor) 
               
               
                 204633_s_at 
                 2.0505228 
                 down 
                 RPS6KA5 
                 ribosomal protein S6 kinase, 90 kDa, 
               
               
                   
                   
                   
                   
                 polypeptide 5 
               
               
                 212443_at 
                 2.0503902 
                 down 
                 NBEAL2 
                 neurobeachin-like 2 
               
               
                 210608_s_at 
                 2.0497348 
                 down 
                 FUT2 
                 fucosyltransferase 2 (secretor status 
               
               
                   
                   
                   
                   
                 included) 
               
               
                 1557036_at 
                 2.0495107 
                 down 
                 ZBTB1 
                 Zinc finger and BTB domain 
               
               
                   
                   
                   
                   
                 containing 1 (ZBTB1), transcript 
               
               
                   
                   
                   
                   
                 variant 1, mRNA 
               
               
                 207950_s_at 
                 2.0490613 
                 down 
                 ANK3 
                 ankyrin 3, node of Ranvier (ankyrin G) 
               
               
                 41858_at 
                 2.0485191 
                 down 
                 FRAG1 
                 FGF receptor activating protein 1 
               
               
                 234513_at 
                 2.0481179 
                 down 
                 ELOVL3 
                 elongation of very long chain fatty 
               
               
                   
                   
                   
                   
                 acids (FEN1/Elo2, SUR4/Elo3, yeast)- 
               
               
                   
                   
                   
                   
                 like 3 
               
               
                 223312_at 
                 2.0474238 
                 down 
                 C2orf7 
                 chromosome 2 open reading frame 7 
               
               
                 204137_at 
                 2.045931 
                 down 
                 GPR137B 
                 G protein-coupled receptor 137B 
               
               
                 229732_at 
                 2.0447505 
                 down 
                 ZNF823 
                 zinc finger protein 823 
               
               
                 206600_s_at 
                 2.0443823 
                 down 
                 LOC100133772 
                 similar to MCT /// solute carrier family 
               
               
                   
                   
                   
                 /// 
                 16, member 5 (monocarboxylic acid 
               
               
                   
                   
                   
                 SLC16A5 
                 transporter 6) 
               
               
                 209099_x_at 
                 2.0436616 
                 down 
                 JAG1 
                 jagged 1 (Alagille syndrome) 
               
               
                 221868_at 
                 2.043276 
                 down 
                 PAIP2B 
                 poly(A) binding protein interacting 
               
               
                   
                   
                   
                   
                 protein 2B 
               
               
                 202790_at 
                 2.0431542 
                 down 
                 CLDN7 
                 claudin 7 
               
               
                 227272_at 
                 2.0418959 
                 down 
                 C15orf52 
                 chromosome 15 open reading frame 52 
               
               
                 200950_at 
                 2.041765 
                 down 
                 ARPC1A 
                 actin related protein 2/3 complex, 
               
               
                   
                   
                   
                   
                 subunit 1A, 41 kDa 
               
               
                 226413_at 
                 2.0407355 
                 down 
                 LOC400027 
                 hypothetical gene supported by 
               
               
                   
                   
                   
                   
                 BC047417 
               
               
                 202039_at 
                 2.0400221 
                 down 
                 MYO18A /// 
                 myosin XVIIIA /// TGFB1-induced 
               
               
                   
                   
                   
                 TIAF1 
                 anti-apoptotic factor 1 
               
               
                 233528_s_at 
                 2.0383992 
                 down 
                 LOC652968 
                 hypothetical protein LOC652968 
               
               
                 211993_at 
                 2.036943 
                 down 
                 WNK1 
                 WNK lysine deficient protein kinase 1 
               
               
                 222668_at 
                 2.0368426 
                 down 
                 KCTD15 
                 potassium channel tetramerisation 
               
               
                   
                   
                   
                   
                 domain containing 15 
               
               
                 204718_at 
                 2.0357015 
                 down 
                 EPHB6 
                 EPH receptor B6 
               
               
                 202192_s_at 
                 2.0352569 
                 down 
                 GAS7 
                 growth arrest-specific 7 
               
               
                 208652_at 
                 2.0350847 
                 down 
                 PPP2CA 
                 protein phosphatase 2 (formerly 2A), 
               
               
                   
                   
                   
                   
                 catalytic subunit, alpha isoform 
               
               
                 226388_at 
                 2.0340674 
                 down 
                 TCEA3 
                 transcription elongation factor A (SII), 3 
               
               
                 226104_at 
                 2.033753 
                 down 
                 RNF170 
                 ring finger protein 170 
               
               
                 224160_s_at 
                 2.0337167 
                 down 
                 ACAD9 
                 acyl-Coenzyme A dehydrogenase 
               
               
                   
                   
                   
                   
                 family, member 9 
               
               
                 209125_at 
                 2.033617 
                 down 
                 KRT6A 
                 keratin 6A 
               
               
                 209529_at 
                 2.0331414 
                 down 
                 PPAP2C 
                 phosphatidic acid phosphatase type 2C 
               
               
                 226860_at 
                 2.0323775 
                 down 
                 TMEM19 
                 transmembrane protein 19 
               
               
                 226644_at 
                 2.0322123 
                 down 
                 MIB2 
                 mindbomb homolog 2 ( Drosophila ) 
               
               
                 203747_at 
                 2.0315192 
                 down 
                 AQP3 
                 aquaporin 3 (Gill blood group) 
               
               
                 1553960_at 
                 2.0313072 
                 down 
                 SNX21 
                 sorting nexin family member 21 
               
               
                 65630_at 
                 2.0311613 
                 down 
                 TMEM80 
                 transmembrane protein 80 
               
               
                 218171_at 
                 2.030586 
                 down 
                 VPS4B 
                 vacuolar protein sorting 4 homolog B 
               
               
                   
                   
                   
                   
                 ( S. cerevisiae ) 
               
               
                 236863_at 
                 2.0298839 
                 down 
                 C17orf67 
                 chromosome 17 open reading frame 67 
               
               
                 205293_x_at 
                 2.0297394 
                 down 
                 BAIAP2 
                 BAI1-associated protein 2 
               
               
                 231115_at 
                 2.0290804 
                 down 
                 POLH 
                 polymerase (DNA directed), eta 
               
               
                 209563_x_at 
                 2.0285957 
                 down 
                 CALM1 /// 
                 calmodulin 1 (phosphorylase kinase, 
               
               
                   
                   
                   
                 CALM2 /// 
                 delta) /// calmodulin 2 (phosphorylase 
               
               
                   
                   
                   
                 CALM3 
                 kinase, delta) /// calmodulin 3 
               
               
                   
                   
                   
                   
                 (phosphorylase kinase, delta) 
               
               
                 205668_at 
                 2.0280306 
                 down 
                 LY75 
                 lymphocyte antigen 75 
               
               
                 204347_at 
                 2.025962 
                 down 
                 AK3L1 /// 
                 adenylate kinase 3-like 1 /// adenylate 
               
               
                   
                   
                   
                 AK3L2 
                 kinase 3-like 2 
               
               
                 222482_at 
                 2.0252454 
                 down 
                 LOC100131851 
                 hypothetical protein LOC100131851 /// 
               
               
                   
                   
                   
                 /// 
                 hypothetical protein LOC100134497 /// 
               
               
                   
                   
                   
                 LOC100134497 
                 similar to single stranded DNA binding 
               
               
                   
                   
                   
                 /// 
                 protein 3 /// hypothetical LOC646674 
               
               
                   
                   
                   
                 LOC401002 
                 /// single stranded DNA binding 
               
               
                   
                   
                   
                 /// 
                 protein 3 
               
               
                   
                   
                   
                 LOC646674 
               
               
                   
                   
                   
                 /// SSBP3 
               
               
                 220056_at 
                 2.023061 
                 down 
                 IL22RA1 
                 interleukin 22 receptor, alpha 1 
               
               
                 211986_at 
                 2.022835 
                 down 
                 AHNAK 
                 AHNAK nucleoprotein 
               
               
                 1555097_a_at 
                 2.0222125 
                 down 
                 PTGFR 
                 prostaglandin F receptor (FP) 
               
               
                 225684_at 
                 2.0216835 
                 down 
                 FAM33A 
                 family with sequence similarity 33, 
               
               
                   
                   
                   
                   
                 member A 
               
               
                 209426_s_at 
                 2.0213833 
                 down 
                 AMACR 
                 alpha-methylacyl-CoA racemase 
               
               
                 203528_at 
                 2.0211873 
                 down 
                 SEMA4D 
                 sema domain, immunoglobulin domain 
               
               
                   
                   
                   
                   
                 (Ig), transmembrane domain (TM) and 
               
               
                   
                   
                   
                   
                 short cytoplasmic domain, 
               
               
                   
                   
                   
                   
                 (semaphorin) 4D 
               
               
                 222895_s_at 
                 2.021075 
                 down 
                 BCL11B 
                 B-cell CLL/lymphoma 11B (zinc 
               
               
                   
                   
                   
                   
                 finger protein) 
               
               
                 230836_at 
                 2.0209422 
                 down 
                 ST8SIA4 
                 ST8 alpha-N-acetyl-neuraminide 
               
               
                   
                   
                   
                   
                 alpha-2,8-sialyltransferase 4 
               
               
                 224443_at 
                 2.0197344 
                 down 
                 C1orf97 
                 chromosome 1 open reading frame 97 
               
               
                 217845_x_at 
                 2.0170114 
                 down 
                 HIGD1A 
                 HIG1 domain family, member 1A 
               
               
                 1555964_at 
                 2.0155482 
                 down 
                 ARL17 /// 
                 ADP-ribosylation factor-like 17 /// 
               
               
                   
                   
                   
                 ARL17P1 
                 ADP-ribosylation factor-like 17 
               
               
                   
                   
                   
                   
                 pseudogene 1 
               
               
                 204061_at 
                 2.0146167 
                 down 
                 PRKX 
                 protein kinase, X-linked 
               
               
                 213572_s_at 
                 2.0136144 
                 down 
                 SERPINB1 
                 serpin peptidase inhibitor, clade B 
               
               
                   
                   
                   
                   
                 (ovalbumin), member 1 
               
               
                 218218_at 
                 2.0132878 
                 down 
                 APPL2 
                 adaptor protein, phosphotyrosine 
               
               
                   
                   
                   
                   
                 interaction, PH domain and leucine 
               
               
                   
                   
                   
                   
                 zipper containing 2 
               
               
                 1554588_a_at 
                 2.0109353 
                 down 
                 TTC30B 
                 tetratricopeptide repeat domain 30B 
               
               
                 201563_at 
                 2.0097337 
                 down 
                 SORD 
                 sorbitol dehydrogenase 
               
               
                 39313_at 
                 2.0081642 
                 down 
                 WNK1 
                 KIAA0344 gene 
               
               
                 225551_at 
                 2.0059721 
                 down 
                 C1orf71 
                 chromosome 1 open reading frame 71 
               
               
                 52285_f_at 
                 2.0037622 
                 down 
                 CEP76 
                 centrosomal protein 76 kDa 
               
               
                 207593_at 
                 2.003508 
                 down 
                 ABCG4 
                 ATP-binding cassette, sub-family G 
               
               
                   
                   
                   
                   
                 (WHITE), member 4 
               
               
                 212115_at 
                 2.0030887 
                 down 
                 HN1L 
                 hematological and neurological 
               
               
                   
                   
                   
                   
                 expressed 1-like 
               
               
                 224605_at 
                 2.0020971 
                 down 
                 C4orf3 
                 chromosome 4 open reading frame 3 
               
               
                 1558882_at 
                 2.0020864 
                 down 
                 LOC401233 
                 similar to HIV TAT specific factor 1; 
               
               
                   
                   
                   
                   
                 cofactor required for Tat activation of 
               
               
                   
                   
                   
                   
                 HIV-1 transcription 
               
               
                 217752_s_at 
                 2.001705 
                 down 
                 CNDP2 
                 CNDP dipeptidase 2 (metallopeptidase 
               
               
                   
                   
                   
                   
                 M20 family) 
               
               
                 204241_at 
                 2.0012212 
                 down 
                 ACOX3 
                 acyl-Coenzyme A oxidase 3, pristanoyl 
               
               
                 219929_s_at 
                 2.0005429 
                 down 
                 ZFYVE21 
                 zinc finger, FYVE domain containing 
               
               
                   
                   
                   
                   
                 21 
               
               
                   
               
               
                 Salicin 0.5% vs Untreated Control 
               
               
                 24 hr treatment 
               
               
                 N = 7 Salicin 0.5%, N = 4 Control 
               
               
                 RMA normalization (performed on all 42 chips together) 
               
               
                 t-test with Benjamini and Hochberg FDR correction 
               
               
                 p-value cut-off: 0.05 
               
               
                 Fold change cutoff: 2.0 
               
            
           
         
       
     
     Selecting Second Subset of Genes 
     Because of the large amount of data associated with the gene expression level changes shown in Table 1, it is desirable to provide a further focus on genes associated with skin and aging. In one embodiment, further data sets extracted from the literature identify genes associated with physical skin aging attributes based on current knowledge of the biochemical pathways in skin to define functional youth gene assemblies. Such an assembly may then provide a gene expression focus for future further work on the same agent used to get the initial full genome data set or for other agents. For this next step, the method first uses a data set that identifies particular genes associated with biochemical pathways in skin  118  (see  FIG. 1C ). 
     Data about the biochemical pathways of genes are available from many sources of scientific literature, including databases of journal articles or from available unpublished data. To make it more useful in the present system, data collected may be supplemented with metadata classifying the conclusions reached in terminology or coding that clearly associates genes with skin or particular skin attributes. (See  FIG. 7  at  786 ). In some embodiments, research is done on biochemical pathways of the skin for any of the genes from Table 1. (See also,  FIG. 7  at  752 ). In some embodiments the biochemical pathway associated with physical appearance of skin aging comprises at least one of skin structural protein synthesis, degradation and maintenance, extracellular matrix assembly, cellular differentiation, skin barrier component synthesis, skin barrier integrity, water regulation, or regulation of melanin production and control. Structural protein synthesis includes, for example, elastin formation, keratinocyte differentiation and collagen production. Skin barrier component synthesis includes, for example, hyaluronic acid synthesis and lipid synthesis. Regulation of melanin production and control includes, for example, UV induced pigmentation and inhibition of tyrosinase. The data set on biochemical pathways associated with the physical appearance of skin aging known for selected genes is preferably collected and stored in database  730  in a format that promotes an intersection analysis with the data of Table 1. This can be done by building a table of all genes known to be associated with a biochemical pathway associated with the physical appearance of skin aging and finding its intersection with Table 1, or by starting the literature search with the genes in Table 1, which have already met the fold change criterion. 
     However approached, the intersection analysis of this step reduces the data of Table 1, by selecting from the first subset of genes a second subset of genes associated with the selected, identified biochemical pathways associated with the physical appearance of skin aging. With reference to the simplified example of  FIG. 1C  of the method, the method selects from genes (b, c, e, f, g and h) based on a biochemical pathway data set derived from review of scientific literature  120 . For example, if in the biochemical pathway data set the gene “h” has no apparent association with a biochemical pathway associated with the physical appearance of skin aging, it may be excluded from the second subset at this point. The resulting genes in the second subset in the simplified example would be (b, c, e, f and g) as shown at  211 . These genes correspond to hypothetical genes found in the intersection analysis to have a biochemical pathway associated with the physical appearance of skin aging. 
     The genes in the second subset for actual test results are categorized according to biological function or association with a plurality of biochemical pathways associated with the physical appearance of skin aging. For the experimental data for 0.05% salicin treated cultures (N=7) compared with untreated control cultures (N=4), Table 2 (see also,  FIG. 7  at  754 ) shows a list of genes derived from Table 1, by selecting from Table 1 approximately 200 genes identified in a data set by their relationship to human skin in the scientific literature. 
     For each gene listed in Table 2, a reference is provided which discusses the mechanism of action/biochemical pathway of the gene. The references are incorporated herein by reference. 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 2 
               
               
                   
               
               
                   
                 Fold 
                   
                 Gene 
                   
               
               
                 Probe Set ID 
                 change 
                 Direction 
                 Symbol 
                 Reference 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
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     Genes not chosen for the second subset of genes may nonetheless be considered for additional research based on secondary research factors  122 . For example, a hypothetical gene may have interesting aging-related pathways, not yet associated with skin, or in the case of hypothetical gene h, a gene may have a high fold value. 
     Grouping Second Subset of Genes with Attributes of Skin 
     Applying to Table 1 the data set specifying the associations with biochemical pathways with the physical appearance of skin aging is a meaningful focusing of the data, which results in the list of Table 2 (See  FIG. 7  at  754 ). Even the shorter list of about 200 genes in Table 2 can benefit from further focus. In particular, it has been found useful to further focus on particular skin attributes that are associated with skin aging. 
     Returning to the flowchart of  FIGS. 1A-1K  for the simplified example, for one or more skin attributes of interest, data is derived from the literature that identifies with each skin attribute the genes and their biochemical pathways that are recognized as affecting the skin attribute  123 . Thus,  FIG. 1D  shows a step of selecting from the second subset of hypothetical genes, which have biologically relevant fold changes and are identified with biochemical pathways with the physical appearance of skin aging, further subsets or groups associated with a particular skin attribute  124 . 
     According to the method, genes of the second subset are further processed into a plurality of subsets (potentially overlapping) within the second subset by categorizing or associating each gene by an association with one or more skin attribute(s). (Gene b is in the subset of skin structure and also in the subset of skin pigmentation). For example, the genes from the second subset may be transformed into skin attribute subsets, each associated with a particular physical sign of skin aging and appearance, listed as follows in  FIGS. 1E and 1F : 
     Skin structure attribute  126 . 
     Skin pigmentation attribute  128 . 
     Skin hydration attribute  130 . 
     Cell turnover attribute  132 . 
     Turning to the second subset as defined for the experimental data listed in Table 2, the use of skin attribute data sets is further explained. A data set identifying the relationship between a particular skin attribute and particular genes is developed based on the literature or on available unpublished data. The data set identifies biochemical pathways of the physical appearance of skin aging known to be associated with one of the genes of Table 2 and a particular skin attribute; it is preferably collected and stored in a format that promotes an intersection analysis with the data of Table 2. This can be done by building a table of all genes known to be associated with a biochemical pathway of the physical appearance of skin aging and a particular skin attribute of interest and finding its intersection with Table 2. In some embodiments, the genes involved in various biochemical pathways related to the particular attribute “skin structure” are chosen for analysis. Some of the biochemical pathways of interest for this skin attribute include skin structural proteins synthesis, degradation and maintenance and extracellular matrix assembly. However, other skin attributes and associated pathways may also be of interest. 
     The attributes skin structure, pigmentation, cell turnover and hydration are described below. One can derive from the literature for each attribute its own subset of genes associated with that attribute, which permits development of a data set identifying the relationship between each of these particular skin attributes and particular genes. However, a gene may be associated with more than one skin attribute. A brief discussion of general principles of skin aging is a useful preface to a discussion of skin attributes. 
     The stratum corneum is the layer of the skin that forms the top surface layer and serves to protect the skin while controlling moisture and the flow of substances in and out of the skin. As this barrier function is broken down, the skin suffers damaging effects, thus further contributing to premature aging. These damaging effects causing premature aging of the skin are a concern for many individuals wishing to maintain healthy, youthful looking and feeling skin. 
     Aging can occur from biological processes or environmental factors, and in some cases environmental factors that impact biological processes. These factors alone and in combination contribute to aging appearance and are responsible for the decline in skin health and function. Biological aging, which is intrinsic, is the result of changes, often genetically determined, that occur naturally within the body. Environmental aging, which is extrinsic, is the result of free radical damage generated by accumulated exposure to sunlight (photoaging), pollution, or cigarette smoke. Also, lifestyle choices like diet, sleep, and stress can affect how quickly one appears to age. 
     Whether from biological or environmental sources, the appearance of aging results from several mechanisms of action or biochemical pathways. For example, a loss of skin structure, a slowing skin cell turnover, pigmentation changes or a decrease in skin hydration. 
     One can group many of the detectable/sensible changes that occur with skin aging into four major skin attributes, skin structure, pigmentation, cell turnover and hydration. By defining these attributes and developing metrics for them, based where possible on instrumentation that makes the metrics more objective, research on interventions can be given focus. For example, with a chosen attribute and one or more genes and one or more biochemical pathways associated with it, the research can focus on particular parts of a biochemical pathway that can be enhanced to encourage the biochemical pathways that produce a more youthful version of that attribute or on inhibiting a biochemical pathway that produces a less youthful version of that attribute. It is believed that the biochemical pathways associated with genes can be regulated by many different factors. The focus on particular genes, particular biochemical pathways associated with the genes and particular skin attributes associated with those pathways may permit identifying an “intervention” where a specific technology can target the gene expression activity for a particular skin attribute to reflect a more youthful gene expression profile, ultimately influencing the physical appearance of the skin as it ages. 
     Functional youth gene assembly, refers to a group of genes, encompassing one or more mechanisms of aging, addressable for functional restoration or stabilization of a more youthful state in the skin. Each functional youth gene assembly may focus on a particular skin attribute that has youthful and non-youthful states. A functional youth gene assembly could also apply to characteristics in other tissues and organs. 
     By extension, a “youth gene family” is composed of a related group of functional youth gene assemblies and would address multiple (or all) the significant attributes of aging for skin (or another tissue or organ, such as adipose tissue, heart, brain, skeletal muscle, etc.). 
     Once it is defined, one can examine a functional youth gene assembly for a specific tissue associated with a specific function. For example, in skin, the youth gene family may comprise functional youth gene assemblies for skin pigmentation, structure, hydration and cell turnover. The skin is an easily accessible organ with easily measured or observed aging attributes. Therefore, one can readily examine manifestations of changed expression levels of a functional youth gene assembly for a specific attribute of skin. 
     This approach is part of an overall strategy to slow down the physical manifestation of the aging process in skin by developing a composition that addresses several genetic mechanisms of aging simultaneously, i.e., through actions targeted to expression levels of the members of functional youth gene assemblies, instead of in-depth analysis of an individual gene. The following focuses on four skin attributes for which it is useful to define a functional youth gene assembly. 
     A. Skin Structure 
     The skin structure group has genes that have biochemical pathways associated with the physical appearance of skin aging that include for example, skin structural proteins synthesis, degradation and maintenance and extracellular matrix assembly. Examples of skin structural protein synthesis include elastin formation, keratinocyte differentiation and collagen production. 
     Younger skin has the ability to balance damage and repair to collagen, a structural protein in the skin. This balance keeps skin looking smooth and wrinkle free. During the aging process, skin begins to lose this balance. Less and less collagen is created and more enzymes are produced which break down this protein resulting in lines and wrinkles. Increasing the production of structural proteins promotes youthful looking skin, whereas inhibiting the production of enzymes that break down the proteins in the skin is also beneficial. 
     B. Pigmentation 
     The pigmentation group has genes that have biochemical pathways associated with the physical appearance of skin aging that include for example, regulation of melanin production and control. All normal human skin contains chromophores that give the skin a characteristic coloration. The color of the skin is mostly due to melanin, eumelanin, hemoglobin and, to some degree, collagen and elastin. The primary function of pigmentation is the absorption of short wavelength light capable of damaging structural components in the deeper layers of the skin and the nuclear and mitochondrial DNA of keratinocytes, melanocytes, fibroblasts, lipocytes, Langerhans cells, other immune system cells and neural cells in the skin. 
     Aside from a sallow appearance, seen in thinner, lighter skinned individuals with poor circulation, around the globe the overall color of the skin does not reflect aging. However, across cultures the irregular distribution of skin color, sometimes called dispigmentation, is a key attribute that characterizes older skin and presents in the form of ephelides, letingines and hyperpigmented or hypopigmented scars. 
     The biochemical changes in the skin that drive an irregular pigmentation pattern can be grouped into several categories. Increased growth factor signaling by melanocyte-stimulating hormone and related cytokines, increased tyrosinase, an enzyme converting tyrosine to DOPA and on to melanin, and increased amounts of melanin transferred from the melanocytes to the keratinocytes. 
     During the aging process, melanocytes can cluster together. These clusters of melanocytes can then become overly active resulting in areas of hyperpigmentation, known as age spots or discoloration. 
     C. Cell Turnover 
     The cell turnover group has genes that have biochemical pathways associated with the physical appearance of skin aging that include for example, cellular differentiation. During the aging process, the outer layers of the skin do not slough off as they once did. The adhesion of these skin cells result in rough skin texture and dull, lifeless looking skin. When cell renewal slows with age, dead skin cells build up along the pores of the skin. This build up increases the appearance of pores, making them look larger than in youthful looking skin. 
     By increasing the cell renewal process, younger, healthier skin cells surface, promoting a smoother skin texture. When skin looks smoother, it reflects light more uniformly. Smoother skin appears more radiant and bright. Increasing cell renewal also stimulates a healthy exfoliation that results in the appearance of tighter pores. 
     D. Hydration 
     The skin hydration group has genes that have biochemical pathways associated with the physical appearance of skin aging that include for example, skin barrier component synthesis, skin barrier integrity and water regulation. Skin barrier component synthesis includes, for example, hyaluronic acid synthesis and lipid synthesis. 
     Moisture-binding glycosaminoglycans (GAG) found within the extracellular skin matrix play a role in the hydration and moisture levels within the skin. Ample moisturization within the extracellular matrix is a factor that helps maintain the strength and integrity of the structural proteins. Many GAGs are too large to enter through the epidermis, but there are ingredients that have been shown to increase GAG production. 
     Each skin attribute may be negatively impacted by one or more mechanisms that contribute to aging in the skin, or may be positively impacted by a mechanism that preserves youthful appearance. If biochemical processes affecting each attribute and the gene expression profile driving those biochemical pathways or processes can be addressed (up-regulated or down-regulated), a skin state more characteristic of a younger individual is established. 
     Referring to the simplified example of  FIGS. 1D-1F , the processing of steps  124 ,  126 ,  128 ,  130 ,  132  begins by focusing on one or more particular skin attributes. For each skin attribute, from the literature a set of genes may be found that has a biochemical pathway relevant to the skin attribute. With sufficient knowledge of the pathway, it can be determined from the literature what the function of the pathway is and thus, whether that pathway will assist a more youthful state of the skin attribute of interest if the pathway is up-regulated or down regulated. The data on a skin attribute and genes with a biochemical pathway relevant to it may be assembled as a dataset for that skin attribute.  FIGS. 1D-1F  show for the simplified genome (a-h) one format. For each of genes a-h in the table at step  120  and for each skin attribute, a row of data can show which genes have association with the skin attribute of interest and show a direction of regulation of the gene expression associated with a more youthful appearance. This is shown in the table at step  123  in one row for each of the skin attributes. (See rows  213   a - 213   d ). As will be seen, these data sets set up the intersection processing for individual skin attributes that leads to the tables at steps  126 ,  128 ,  130 , and  132 . 
     Correspondingly, for the microarray data in Table 2, from the genes in Table 2 a data set can be prepared that show association for a chosen skin attribute of interest, which of these genes has a pathway relevant to the skin attribute of interest and from the function of that pathway can be determined a direction of regulation of the gene associated with a more youthful appearance. The association of a gene and its pathway and one or more skin attributes may come from published or private research. Table 3 shows a dataset taken form the genes in Table 2, and identifying those genes with a pathway relevant to the skin attribute “skin structure”. For each gene in the list (of Table 3) there is a column entry in which a function relative to the skin attribute appears. The resulting skin attribute data set may be input into a database  730 , by a suitable process application module that stores and accesses such data and uses it for processing as contemplated by steps  124 ,  126 ,  128 ,  130 ,  132  in the hypothetical example. 
     The intersection analysis for the microarray data in Table 3 is similar to that shown in steps  124 ,  126 ,  128 ,  130 ,  132  (which deal with all four skin attributes identified above; for the data in Table 2, there is only one example skin attribute addressed in Table 3). The skin attribute data set of Table 3 may be processed to derive a skin attribute subset for a preliminary functional gene assembly. As the data of Table 2 is processed by intersection with a skin attribute data set designating genes with an association with a skin attributes of interest, it becomes necessary to consider for each gene the literature-reported regulation direction for the more youthful state of the skin attribute of interest. If a gene happens to have an association with more than one attribute, then a regulation direction for each skin attribute is identified in the particular skin attribute data set; up-regulation of a gene might be favorable for one skin attribute and down-regulation of the gene favorable for a different attribute. 
     Referring to again to  FIG. 1D  of the simplified example, the table at  123 , rows  213   a - d  show a simplified hypothetical example of how the datasets on genes of interest may reflect how the hypothetical genes are associated with a particular skin attribute and whether a pathway identified with the gene has an up or down regulation relative to a youthful direction for the particular skin attribute. Thus, for the “skin structure” attribute, genes b and f are shown as having an up-regulation association with a more youthful appearance as to that attribute. For “skin pigmentation”, genes b and c are shown as having an up-regulation association with more youthful appearance as to that attribute. For “skin hydration”, genes c and g are shown as having a down-regulation association, and gene e is shown as having an up-regulation association with more youthful appearance as to that attribute. For cell turnover, gene e is shown as having an up-regulation association and gene f is shown as having a down-regulation association with more youthful appearance as to that attribute. 
     As for the microarray data, Table 3, shows a data set comprising genes from Table 2 for which the literature shows a connection to the skin structure attribute, including a function with respect to skin structure which will determine the more youthful regulation direction. Once the more youthful regulation direction is specified for a gene, the data set of Table 3 can be used for intersection processing to find a skin attribute subset list for the gene assembly for the skin structure attribute. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE 3 
               
               
                   
               
               
                 Probe 
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     As a gene associated with a skin aging attribute can be a part of a specific biochemical pathway involved in the physical appearance of skin aging that improves the skin attribute in a youthful direction or one that can be a part of a specific biochemical pathway that increases the appearance of skin aging (i.e., changes skin appearance in a non-youthful direction), the intersection processing requires additional logic to include in the gene assembly for a particular skin attribute only those genes that are regulated in a direction reflective of youthful skin appearance. Thus, the genes of Table 3 (see also,  FIG. 7  at  756 ) are processed by a module identifying which genes were reported in the microarray a regulated in a direction (up or down regulated) that is the desired, more youthful direction. This criterion removes from the preliminary gene assembly of Table 3 any gene for which the microarray data shows that it up-regulates a pathway that decreases youthful appearance or that down-regulates a pathway that increases youthful appearance. This directional logic is step  134  of  FIG. 1G . 
     Returning to the simplified, hypothetical example,  FIGS. 1E and 1F , rows  215   a - d  show for each skin attribute the results or the answer to the question, whether or not the gene stays in the group. In the skin structure attribute example  126 , gene b has a fold change greater than 2, and the up regulation of that gene from the (hypothetical) gene expression level is consistent with the data from the literature that indicates that up regulation of that gene provides more youthful skin structure. However, gene f has a fold change greater than 2, but the down regulation shown by the (hypothetical) gene expression level for gene f is not consistent with the data from the literature. According to the (hypothetical) literature, down regulation of gene f provides a less youthful skin appearance. Therefore, gene b is kept in the group, while gene f is dropped from the group at this time. 
     For the skin pigmentation attribute  128  of the simplified example, genes b and c have a fold change greater than 2, and the up regulation of genes b and c from the (hypothetical) gene expression level are consistent with the data from the literature indicating that up regulation of both genes b and c provide more youthful skin structure. Therefore, both genes b and c are kept in the group. 
     In the skin hydration attribute  130  of the simplified example, genes c and g have a fold change greater than 2, but the up regulation shown by the (hypothetical) gene expression level is not consistent with the data from the literature. According to the (hypothetical) literature, down regulation of genes c and g provide a more youthful skin appearance. Gene e has a fold change greater than 2, and the up regulation of that gene from the (hypothetical) gene expression level is consistent with the data from the (hypothetical) literature indicating that up regulation of that gene provides more youthful skin structure. Therefore, genes c and g are dropped from the group at this time, but gene e is kept in the group. 
     In the cell turnover attribute  132  of the simplified example, gene e has a fold change greater than 2, and the up regulation of that gene from the (hypothetical) gene expression level is consistent with the data from the (hypothetical) literature indicating that up regulation of that gene provides more youthful skin structure. Gene f has a fold change greater than 2, and the down regulation of that gene from the (hypothetical) gene expression level is consistent with the data from the literature that indicates that down regulation of that gene provides more youthful skin structure. Therefore, both genes e and f are kept in the group. 
     Table 4 shows the result when the processing logic of the simplified example is applied to the data from actual microarray testing of tissue exposed to salicin and when the skin attribute is “skin structure”, which is the focus of the data set in Table 3. The intersection processing module using the data of Table 3 identifies those genes that not only have an association with skin structure but also have been found in the test data to be up-regulating a pathway that provides more youthful skin structure or genes down-regulating a pathway that provides less youthful skin structure. 
     Table 4 (see also,  FIG. 7  at  758 ) shows for the Affymetrix testing-derived data a group of genes exhibiting expression levels in a direction reflective of youthful skin appearance for the “skin structure” attribute. The up/down gene regulation shown by Affymetrix testing is thus for some genes consistent with scientific literature as to regulation of the gene in a more “youthful” direction. Table 4 is a subgroup of Table 3 and is a second subset of genes, further defined by applying the method steps sketched in  FIGS. 1A-1G  of the simplified example (through step  134 ) for the skin attribute “skin structure”. 
     Genes in Table 3 not chosen for Table 4 based on the logic requiring the alignment of the Affymetrix testing-derived data with the literature&#39;s position on regulation of the gene in a “youthful” direction may nonetheless be considered for additional research on “skin structure” but that must be based on secondary research factors. Table 4 shows only the genes that have the required alignment of “youthful” direction for “skin structure” in both the literature and the Affymetrix testing-derived data. 
                                             TABLE 4               Probe   Fold       Gene                   Set ID   change   Direction   Symbol   Gene Title   Function   Reference                  239272_at   4.074428   down   MMP28   matrix   Destroys   Matrix Biol. 2009                       metallopepti-   Collagen   March; 28(2): 74-83.                       dase 28       Epub 2009 Jan. 20       208188_at   3.736902   down   KRT9   keratin 9   structural   Mech Ageing                           protein   Dev. 2008                               October; 129(10):                                563-71. Epub 2008                               Jun. 3.       201820_at   3.736902   down   KRT5   keratin 5   Structural   Mech Ageing                           protein   Dev. 2008                               October; 129(10):                                563-71. Epub 2008                               Jun. 3.       202643_s_at   6.915339   up   TNFAIP3   tumor   Negative   FEBS Lett. 2003                       necrosis   Feedback   Feb. 11; 536(1-3):                       factor, alpha-   of NFKA   135-40                       induced   (aging                           protein 3   marker)           215078_at   5.712224   up   SOD2   superoxide   Protects   Journal of                       dismutase 2,   from UV   Investigative                       mitochondrial   damage   Dermatology                               (1994) 102, 476-                               480       215910_s_at   3.663163   up   FNDC3A   fibronectin   Collagen   FEBS Lett. 1994                       type III   Assembly   Apr. 18; 343(1):                       domain       47-50                       containing 3A               216005_at   2.719327   up   TNC   Tenascin   ECM   Dev Dyn. 2000                           Remodelling   June; 218(2): 235-                               59.       211958_at   2.711879   up   IGFBP5   insulin-like   Collagen   Arthritis Rheum.                       growth factor   Deposition   2006 September;                        binding       54(9): 3001-10                       protein 5               214702_at   2.709946   up   FN1   fibronectin 1   Structural   Exp Cell Res.                           protein   1990 November;                               191(1): 8-13       202724_s_at   2.098236   up   FOXO1   forkhead box   Induces   Am J Physiol Cell                       O1   Collagen   Physiol 292:                           Synthesis   C850-C856, 2007       201150_s_at   2.057974   up   TIMP3   TIMP   Inhibits   J Invest                       metallopepti-   MMP&#39;s   Dermatol. 1998                       dase inhibitor 3       April; 110(4): 416-                               21       203184_at   2.028269   up   FBN2   fibrillin 2   Elastin   J Invest Dermatol.                            Fibre   1996 May;                            Formation   106(5): 1090-5       1561042_at   2.150782   up   ITGB1   integrin, beta 1   Marker for   Br J Dermatol.                           skin   2003 April;                           structural   148(4): 770-8                           damage                               caused by                               UV           211981_at   2.121121   up   COL4A1   Collagen   Skin   J Clin Invest.                       Type 4 Alpha 1   Structural   1989 March;                           protein   83(3): 791-795                    
Youthful direction based on published literature.
 
     As can be seen, with a data set like Table 3 derived for other skin attributes, a table like Table 4 can be derived for skin attributes other than “skin structure”. 
     Confirmation 
     Determination of RNA Quantification for Second Subset of Genes 
     A gene assembly developed to the status of Table 4 may be further confirmed and refined by a different methodology with a different gene analysis tool, in particular, by performing further skin model testing that takes advantage of the narrowing of focus to a list of genes as in Table 4. 
     Different methodologies include determining RNA types and levels by RNA quantification metrics including, for example, Northern blot technique, Ribonuclease Protection Assay (RPA) and Real Time Polymerase Chain Reaction (RT-PCR). 
     Northern blot is a well-known process for detecting and quantifying mRNA levels. The northern blotting technique is often used for comparison of gene expression patterns for different tissue types. In terms of skin genomics, it is less used than the modern techniques but can be used as confirmation step in understanding gene expression in the skin. 
     Northern blots start with the extraction and isolation of mRNA from the sample. RNA samples are then separated by gel electrophoresis. Once separated, the RNA is then transferred to a positively charged membrane, most often made of nylon. Once transferred to the membrane, RNA is then immobilized to the membrane through covalent linkage with the use of UV light or heat. Hybridization probes (fragment of DNA or RNA used to detect the presence of specific sequences) to be used for the experiments are labeled and placed on the membrane for hybridization. The membrane is then washed to ensure probe binding is strong as well to avoid background signals. The signals are then detected by X-ray film and can be quantified by densitometry. (Alberts, B., et al.  Molecular Biology of the Cell,  5 th ed . pp. 538-539, New York: Taylor &amp; Francis Group (2008)). 
     Ribonuclease protection assay is a sensitive technique for detection, quantification and characterization of RNA. Isolated RNA is hybridized to a single stranded cDNA of the gene of interest. After annealing, the sample is subject to enzymatic digestion to remove all single stranded nucleic acids, leaving only double-stranded RNA. The double stranded nucleic acid fragments are then separated on high-resolution polyacylamide gels. Quantification is carried out similar to that of Northern Blot. The assay is much more sensitive than Northern blot, and can be used to quantify mRNAs that are expressed at low levels. (Applied Biosystems, Inc.,  The Basics: What is a Nuclease Protection Assay?© 2010, last accessed May 18, 2010, from http://www.ambion.com/techlib/basics/npa/index.html). 
     Real Time Polymerase Chain Reaction is a laboratory technique used for DNA quantification, which measures the accumulation of DNA product after each round of PCR amplification. This laboratory technique is also known as quantitative real time polymerase chain reaction (RTQ-PCR/Q-PCR/qPCR) or kinetic polymerase chain reaction, which is used to amplify and simultaneously quantify a targeted DNA molecule. The technique enables both detection and quantification (as absolute number of copies or relative amount when normalized to DNA input or additional normalizing genes) of one or more specific sequences in a DNA sample. 
     The amplified DNA is detected as the reaction progresses in real time, as compared to standard PCR, where the product of the reaction is detected at its end. Two common methods for detection of products in real-time PCR are: (1) non-specific fluorescent dyes that intercalate with any double-stranded DNA, and (2) sequence-specific DNA probes consisting of oligonucleotides that are labeled with a fluorescent reporter which permits detection only after hybridization of the probe with its complementary DNA target. 
     Reverse Transcription PCR (RT-PCT) is used for amplifying DNA from RNA. Reverse transcriptase reverse transcribes RNA into cDNA, which is then amplified by PCR. RT-PCR allows for a high sensitivity detection technique, where low copy number or less abundant RNA molecules can be detected. RT-PCR is widely used in expression profiling, to determine the expression of a gene or to identify the sequence of an RNA transcript, including transcription start and termination sites. 
     Real-time PCR may be combined with reverse transcription to quantify messenger RNA and Non-coding RNA in cells or tissues. Real-time reverse-transcription PCR is also known as qRT-PCR, RRT-PCR, or RT-rt PCR. 
     In some embodiments, Real Time Reverse Transcriptase Polymerase Chain Reaction (RT-rt-PCR) experiments on the second subset of genes are performed to confirm activity of the skin anti-aging agent acting on the gene. 
     In some embodiments, determining the levels of expression for the second subset of genes is done by using an RNA quantification metric. Selecting a further set of genes from a previous set of genes in a second sample of human skin tissue is based on measured levels of expression, which meet a criterion of biological relevance. 
     As seen in  FIG. 1G  of the simplified example, to perform confirmation of a skin attribute subset, or a preliminary functional youth gene assembly the next step is to expose a second sample of human or human equivalent skin tissue to the agent  136 . Preferably this is done with the same skin model as used with the microarray technology for measuring global gene expression. The qualities of the agent (concentration, solvent, etc.) should normally be the same. 
     In some embodiments, the agent tested is salicin at a concentration of 0.5% salicin, available from Symrise Corporation (Teterborro, N.J.). The salicin is dissolved in water. Affymetrix microarray testing provides results for thousands of genes, whereas RT-rt-PCR testing provides results for a smaller gene group. For RT-rt-PCR testing, about 90 genes are tested at a time for this particular experimental design (other designs may test as many as 390 at a time on the equipment identified below). The experimenter may choose this number based on cost. 
     To start a process of confirmation using a second gene analysis tool that works with smaller arrays and a different, perhaps more sensitive measurement of regulation by the agent, expose a second sample of human skin tissue to the agent and select a set of candidate genes for confirmation. For example, the set of candidate genes may be the genes of a preliminary functional youth gene assembly of a particular skin attribute, supplemented with a few other genes that are of interest based on secondary research. More that one candidate group may of course be explored by confirmation. For example, a candidate group may be built around the preliminary functional youth gene assembly of each of the skin attributes discussed above: skin structure, skin pigmentation, skin hydration and cell turnover. 
     The subsets of genes related to a particular skin attribute are conveniently tested on one test card. Referring again to the process schematically shown for a simplified hypothetical gene set in  FIGS. 1A-1G , the next step is to determine quantification of RNA and directions of regulation in the second exposed sample for each of the skin attribute subdivisions of the second subset of genes using a determination method different than for the first exposed sample  138 , for example, using an RT-rt-PCR method, for each attribute. For the simplified example set of genes of  FIG. 1G , we may assume all genes from all four attributes are tested on one chip. 
     To implement this step, RT-rt-PCR is conducted for specific genes known to be involved in skin aging. In one embodiment Custom TaqMan® Low Density Arrays (TLDA&#39;s) were configured using Applied Biosystems validated gene expression assays. The validated gene expression assays contain a TaqMan® fluorescent probe and primers for each target gene. Genes for the TLDA cards are selected based on either, published literature describing the genes functional role in skin cell biology and aging and/or the previous Affymetrix testing results. (See Tables 1-4). Five endogenous control genes may be included on each card. Thus, when a particular gene assembly is tested with RT-rt-PCR, the data resulting may cover more than just the set of genes as in Table 3. 
     cDNA is synthesized from an aliquot of total RNA using the High Capacity cDNA reverse transcription kit from Applied Biosystems (Foster City, Calif.) according to the manufacturer&#39;s suggested protocols. (High-Capacity cDNA Reverse Transcription Kits for 200 and 1000 Reactions Protocol (October, 2006)). cDNA was mixed with TaqMan® Universal Master Mix without UNG and loaded into the wells of the TLDA cards. The cards are run using an Applied Biosystems 7900HT instrument according to the manufacturer&#39;s cycling parameters. 
     As with the microassay, the analysis is done with a skin model exposed to the agent and a reference that is not exposed to the agent. The skin model not exposed to the agent may be used for calibration. The skin model may be human equivalent skin tissue. The target genes get normalized to a stable endogenous control (genes that are invariants in all cell types such as β 3 -actin). This normalization is to account for variations that may occur during sample loading. The unexposed information gathered is used for comparison against the tested sample. 
     The formula for ΔC T  (delta cycle threshold) is C T  (target) minus C T  (endogenous control gene). (ΔC T =C T  (target)−C T  (endogenous control gene)). The test system, data processing system  710  stores the data then uses process application modules  720  to take the C T  values for both the exposed and unexposed and get a ΔΔC T  value, which is reported for that specific gene in a log ratio scale. Once this data is collected and stored, such as in database  730  (see  FIG. 7 ), it is analyzed by conducting bioinformatics statistical analysis on data  140 . In one embodiment, data analysis is carried out according to the RQ analysis method using RQ Manager and StatMiner (v3.1) software programs. 
     At least part of the comparing of the data is performed by a computer system, such as the data processing system  710  (see  FIG. 7 ) for performing data access and storage and various computations specified by software (process application modules  720 ) corresponding to the functions occurring at various described steps of this method. Additional process application modules  722  perform a parametric t-test with a Benjamini and Hochberg false discovery rate correction is performed to identify genes with a statistically significant p value equal to or less than 0.05. The up or down regulation of the gene is also identifiable from the RT-rt-PCR analysis. Results of the change in threshold cycle (ΔC T ) values between the exposed and unexposed human skin tissues are calculated by a software program. The selected genes will have a cycle threshold of biological relevance. For these experiments, the selected genes have a cycle threshold of less than about &lt;35, which is a value of biological relevance. In every cycle of PCR (C T  value) the amount of DNA is approximately duplicated, thus, the C T  is in the logarithmic scale and inversely proportional to the quantity of DNA/RNA. Therefore, high C T  values represent low expression while highly expressed genes have low C T  values. Comparing the normalized expression of the two conditions it is possible to calculate the fold change of the expression of the gene, ΔΔC T  value. The fold change is the expression ratio: if the fold change is positive it means that the gene is up-regulated; if the fold change is negative it means it is down-regulated. This is represented in a log scale. 
     The C T  or cycle threshold is defined as the number of cycles required for the fluorescent signal to cross the threshold. C T  levels are inversely proportional to the amount of target DNA in the same. Standard real time reactions undergo 40 cycles of amplification. C T &lt;20 indicate strong positive reactions and an abundance of the targeted DNA. C T  values of 30-37 are positive reactions indicative of moderate amounts of target DNA. C T  values of 38-40 are weak reactions indicative of minimal amounts of target DNA. The C T  values are an criterion of biological relevance. The experimenter optionally chooses a criterion based on biological relevance for gene expression in aging skin. 
     Table 5 (see also,  FIG. 7  at  762 ) shows a testing-derived example of quantitative measurements of gene expression and the direction of regulation for genes associated with the skin attribute “skin structure”, derived from RT-rt-PCR analysis. As can be seen, the number of genes in Table 5 exceeds that in Table 4. This reflects that, in some cases, it may be useful to add to a test card a gene that did not show a sufficient fold change in the microarray data but is identified with a strong anti-aging effect or is otherwise known to be of possible interest for this skin attribute. It also may be useful to add to a test card a gene that showed a sufficient fold change in microarray data but has not yet been identified with a strong anti-aging effect. Optionally, the experimenter could add to a test card a gene that has a fold change greater than the selected fold change criterion (e.g., 2), but the regulation direction shown by the first gene expression level testing is not consistent with the data from the literature. This can provide a useful second look at a gene. 
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 5 
               
               
                   
               
               
                 Gene 
                 Gene 
                   
                   
                   
                   
               
               
                 Symbol 
                 Function 
                 Direction 
                 p-value 
                 Log10RG 
                 Reference 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 COL4A6 
                 Structural 
                 no data 
                   
                   
                 The Journal of Cell 
               
               
                   
                 protein in 
                   
                   
                   
                 Biology, Vol 130, 
               
               
                   
                 skin 
                   
                   
                   
                 1219-1229, Copyright © 
               
               
                   
                   
                   
                   
                   
                 1995 
               
               
                 SDC1 
                 Cell- 
                 down 
                 0.002811879 
                 −0.396098529 
                 Arch Dermatol Res. 
               
               
                   
                 extracellular 
                   
                   
                   
                 2008 August; 300(7): 
               
               
                   
                 matrix 
                   
                   
                   
                 393-395 
               
               
                   
                 interactions 
               
               
                 KRT1 
                 Epidermal 
                 down 
                 0.001131397 
                 −1.111598451 
                 Gene Expr Patterns. 
               
               
                   
                 structural 
                   
                   
                   
                 2005 Aug; 5(6): 801-8 
               
               
                   
                 protein 
               
               
                 MMP28 
                 Destroys 
                 no data 
                   
                   
                 Matrix Biol. 2009 
               
               
                   
                 Collagen 
                   
                   
                   
                 Mar; 28(2): 74-83. 
               
               
                   
                   
                   
                   
                   
                 Epub 2009 Jan 20 
               
               
                 KRT6B 
                 Epidermal 
                 no data 
                   
                   
                 Acta Derm Venereol 
               
               
                   
                 structural 
                   
                   
                   
                 2004; 84: 18-22 
               
               
                   
                 protein 
               
               
                 KRT15 
                 Epidermal 
                 no data 
                   
                   
                 J Invest Dermatol. 
               
               
                   
                 structural 
                   
                   
                   
                 1999 Mar; 112(3): 362-9 
               
               
                   
                 protein 
               
               
                 COL17A1 
                 Structural 
                 no data 
                   
                   
                 http://ghr.nlm.nih.gov/gene=col17a1 
               
               
                   
                 protein in 
               
               
                   
                 the skin 
               
               
                 FILIP1L 
                 Cytoskeleton 
                 no data 
                   
                   
                 Nature Genetics 33, 
               
               
                   
                 remodelling 
                   
                   
                   
                 487-491 (2003) 
               
               
                   
                   
                   
                   
                   
                 Published 
               
               
                   
                   
                   
                   
                   
                 online: March 2003;| 
               
               
                   
                   
                   
                   
                   
                 doi:10.1038/ng1119 
               
               
                 DSP 
                 Cellular 
                 down 
                 0.017260177 
                 −0.222288576 
                 FASEB J. 1996 
               
               
                   
                 Adhesion 
                   
                   
                   
                 Jun; 10(8): 871-81. 
               
               
                   
                 protein 
               
               
                 KRT9 
                 Structural 
                 no data 
                   
                   
                 Mech Ageing Dev. 
               
               
                   
                 protein 
                   
                   
                   
                 2008 
               
               
                   
                   
                   
                   
                   
                 Oct; 129(10): 563-71. 
               
               
                   
                   
                   
                   
                   
                 Epub 2008 Jun 3. 
               
               
                 KRT5 
                 Structural 
                 down 
                 0.001982117 
                 −0.444955798 
                 Mech Ageing Dev. 
               
               
                   
                 protein 
                   
                   
                   
                 2008 
               
               
                   
                   
                   
                   
                   
                 Oct; 129(10): 563-71. 
               
               
                   
                   
                   
                   
                   
                 Epub 2008 Jun 3. 
               
               
                 CAT 
                 Protects 
                 down 
                 0.000701114 
                 −0.476760771 
                 Journal of 
               
               
                   
                 from UV 
                   
                   
                   
                 Investigative 
               
               
                   
                 damage 
                   
                   
                   
                 Dermatology (2006) 
               
               
                   
                   
                   
                   
                   
                 126, 182-190 
               
               
                 TNFAIP3 
                 Negative 
                 no data 
                   
                   
                 FEBS Lett. 2003 Feb 
               
               
                   
                 Feedback of 
                   
                   
                   
                 11; 536(1-3): 135-40 
               
               
                   
                 NFKA 
               
               
                   
                 (aging 
               
               
                   
                 marker) 
               
               
                 SOD2 
                 Protects 
                 up 
                 0.027437424 
                 0.302541956 
                 Journal of 
               
               
                   
                 from UV 
                   
                   
                   
                 Investigative 
               
               
                   
                 damage 
                   
                   
                   
                 Dermatology (1994) 
               
               
                   
                   
                   
                   
                   
                 102, 476-480 
               
               
                 FNDC3A 
                 Collagen 
                 no data 
                   
                   
                 FEBS Lett. 1994 Apr 
               
               
                   
                 Assembly 
                   
                   
                   
                 18; 343(1): 47-50 
               
               
                 FGF2 
                 Inhibits 
                 no data 
                   
                   
                 Arteriosclerosis, 
               
               
                   
                 matrix 
                   
                   
                   
                 Thrombosis, and 
               
               
                   
                 collagen 
                   
                   
                   
                 Vascular Biology. 
               
               
                   
                 synthesis 
                   
                   
                   
                 1993; 13: 680-686 
               
               
                 TNC 
                 ECM 
                 up 
                 0.001112139 
                 0.142852906 
                 Dev Dyn. 2000 
               
               
                   
                 Remodelling 
                   
                   
                   
                 Jun; 218(2): 235-59. 
               
               
                 IGFBP5 
                 Collagen 
                 no data 
                   
                   
                 Arthritis Rheum. 2006 
               
               
                   
                 Deposition 
                   
                   
                   
                 Sep; 54(9): 3001-10 
               
               
                 FN1 
                 Structural 
                 up 
                 0.027437424 
                 0.241122656 
                 Exp Cell Res. 1990 
               
               
                   
                 protein 
                   
                   
                   
                 Nov; 191(1): 8-13 
               
               
                 TNFAIP6 
                 Induces 
                 no data 
                   
                   
                 BMC Immunol. 2009 
               
               
                   
                 MMP&#39;s 
                   
                   
                   
                 Mar 19; 10: 15 
               
               
                 SMAD7 
                 Negative 
                 up 
                 0.001982117 
                 0.232529868 
                 J Biol Chem. 2005 
               
               
                   
                 regulator of 
                   
                   
                   
                 Mar 4; 280(9): 8079-85. 
               
               
                   
                 collagen 
                   
                   
                   
                 Epub 2004 Dec 3 
               
               
                   
                 synthesis 
               
               
                 PRKCA 
                 Stimulates 
                 up 
                 0.01950064 
                 0.274898033 
                 Free Radic Biol Med. 
               
               
                   
                 Collagenase 
                   
                   
                   
                 1999 Oct; 27(7-8): 729-37 
               
               
                 FOXO1 
                 Induces 
                 up 
                 0.036848433 
                 0.238284357 
                 Am J Physiol Cell 
               
               
                   
                 Collagen 
                   
                   
                   
                 Physiol 292: C850-C856, 
               
               
                   
                 Synthesis 
                   
                   
                   
                 2007 
               
               
                 TIMP3 
                 Inhibits 
                 no data 
                   
                   
                 J Invest Dermatol. 
               
               
                   
                 MMP&#39;s 
                   
                   
                   
                 1998 Apr; 110(4): 416-21 
               
               
                 FBN2 
                 Elastin Fibre 
                 no data 
                   
                   
                 J Invest Dermatol. 
               
               
                   
                 Formation 
                   
                   
                   
                 1996 
               
               
                   
                   
                   
                   
                   
                 May; 106(5): 1090-5 
               
               
                 LOR 
                 Component 
                 down 
                 0.000701114 
                 −1.920784953 
                 J Biol Chem. 1992 
               
               
                   
                 of Cornefied 
                   
                   
                   
                 Sep 5; 267(25): 18060-6. 
               
               
                   
                 envelope 
               
               
                 KLK8 
                 Break down 
                 no data 
                   
                   
                 Journal of 
               
               
                   
                 of cellular 
                   
                   
                   
                 Investigative 
               
               
                   
                 adhesion 
                   
                   
                   
                 Dermatology (2005) 
               
               
                   
                 proteins 
                   
                   
                   
                 125, 1182-1189 
               
               
                 DSC3 
                 Cellular 
                 down 
                 0.005260102 
                 −0.293838188 
                 FASEB J. 1996 
               
               
                   
                 Adhesion 
                   
                   
                   
                 Jun; 10(8): 871-81. 
               
               
                   
                 protein 
               
               
                 PKP3 
                 Cellular 
                 no data 
                   
                   
                 FASEB J. 1996 
               
               
                   
                 Adhesion 
                   
                   
                   
                 Jun; 10(8): 871-81. 
               
               
                   
                 protein 
               
               
                 KLK10 
                 Cellular 
                 no data 
                   
                   
                 J Invest Dermatol 
               
               
                   
                 Adhesion 
                   
                   
                   
                 2003 121: 542-549 
               
               
                   
                 protein 
               
               
                 S100A8 
                 Increases 
                 down 
                 0.001131397 
                 −0.63072926 
                 Arch Dermatol Res. 
               
               
                   
                 with 
                   
                   
                   
                 2009 Aug; 301(7): 523-9. 
               
               
                   
                 photoaging- 
                   
                   
                   
                 Epub 2009 May 23. 
               
               
                   
                 destroys 
               
               
                   
                 proteins 
               
               
                 IL6 
                 Stimulates 
                 up 
                 0.001131397 
                 0.932203049 
                 Journal of 
               
               
                   
                 MMP&#39;s 
                   
                   
                   
                 Investigative 
               
               
                   
                   
                   
                   
                   
                 Dermatology (2004) 
               
               
                   
                   
                   
                   
                   
                 123, 1012-1019 
               
               
                 ITGB4 
                 Required for 
                 down 
                 0.001131397 
                 −0.828309922 
                 J Cell Biol. 1996 July 
               
               
                   
                 cell to cell 
                   
                   
                   
                 2; 134(2): 559-572 
               
               
                   
                 adhesion 
               
               
                 S100A9 
                 Mediates 
                 down 
                 0.001131397 
                 −0.651297398 
                 Biochem Biophys Res 
               
               
                   
                 fibronectin 
                   
                   
                   
                 Commun. 2007 March 
               
               
                   
                 adhesion 
                   
                   
                   
                 2; 354(1): 84-89 
               
               
                 ITGB1 
                 Marker for 
                 up 
                 0.01401738 
                 9.36E−02 
                 Br J Dermatol. 2003 
               
               
                   
                 skin 
                   
                   
                   
                 Apr; 148(4): 770-8 
               
               
                   
                 structural 
               
               
                   
                 damage 
               
               
                   
                 caused by 
               
               
                   
                 UV 
               
               
                 COL4A1 
                 Skin 
                 up 
                 0.016310135 
                 0.208638283 
                 J Clin Invest. 1989 
               
               
                   
                 Structural 
                   
                   
                   
                 March; 83(3): 791-795 
               
               
                   
                 protein 
               
               
                   
               
               
                 Taqman TLDA Analysis 
               
               
                 Relative Quantition - T-test with Benjamini and Hochberg correction 
               
               
                 HPRT as Endogenous Control Gene 
               
               
                 Untreated Control as Calibrator 
               
               
                 p value &lt;0.05 
               
               
                 Salicin 0.5% vs. Untreated Control 
               
            
           
         
       
     
     Selecting Third Subset of Genes 
     Functional Youth Gene Assembly 
     Results from the RT-rt-PCR experiments may or may not confirm that the candidate genes subject to confirmation testing are regulated in the direction reflective of youthful appearing skin based on the published scientific literature. 
     The RT-rt-PCR data thus provide an additional basis for refining a gene functional youth gene assembly that is derived from steps  102 - 134  of  FIGS. 1A-1G . If a gene as tested for a gene assembly is not confirmed as having the same direction that led to its selection from steps  102 - 134 , it may now be removed as a member of the gene assembly. Because the RT-rt-PCR data provide a new reading on the level of expression, a further expression level threshold can applied as a criterion for membership in an assembly. Genes are selected from those with expression levels determined based on a relative quantification analysis. 
     Referring now to the simplified example shown in  FIG. 1G , the next step is to select from the previously subdivided groups from the second subset of genes (the functional youth gene assemblies), a third subset of genes also subdivided by skin attribute regulated in a direction reflective of youthful skin appearance, with an appropriately selected biological relevance level, e.g., a cycle criterion level (for example, the criterion could be selected at 35 cycles or less). (For PCR data, the lower the cycle number, the stronger the gene expression.) 
     In  FIG. 1G  is a table showing a set of hypothetical results for the simplified sample set of genes a-h; in particular, it shows in row  216  ΔC T  values for genes b, c, e, f, g and h. (In the simplified example, we have assumed that genes a and d have no values from RT-rt-PCR, as those genes were previously filtered out of the second subset.) 
     As noted, some genes dropped at earlier stages of the process outlined in  FIGS. 1G-1K  may be reconsidered by adding them back into the RT-rt-PCR testing. In the simplified example, gene h shows a sufficient fold change in the hypothetical microarray data but has not yet been identified with a strong anti-aging effect. In the simplified example, gene g has a fold change greater than 2, but the regulation direction shown by the first gene expression level testing was not consistent with the data from the literature. Assuming gene g and gene h were reconsidered during the RT-rt-PCR testing, this results in hypothetical data in row  216 - 218 . 
     Referring to  FIGS. 1G-1K  describing the simplified example, the confirmation of direction of regulation criterion and the ΔC T  criterion are applied to the hypothetical data in row  216 - 218  to confirm/reject the results shown in the selection of genes in the table at  126  (corresponding to Table 4 derived from Affymetrix microarray testing data) to arrive at the following results for the simplified hypothetical: 
     Functional youth gene assembly for skin structure  144 : Gene b is confirmed because it meets the ΔC T  criterion and matches the direction of expression associated with more youthful skin structure per the literature data set on skin structure. 
     Functional youth gene assembly for skin pigmentation  146 : Gene b is confirmed because it meets the ΔC T  criterion and matches the direction of expression associated with more youthful skin pigmentation per the literature data set on skin pigmentation. Gene c is not confirmed because it does not meet the ΔC T  criterion. 
     Functional youth gene assembly for skin hydration  148 : Gene e is not confirmed because it does not meet the ΔC T  criterion. Gene g is added because it meets the ΔC T  criterion and matches the direction of expression associated with more youthful skin hydration per the literature data set on skin hydration. This is contrary to the microarray data. 
     Functional youth gene assembly for cell turnover  150 : Gene e is not confirmed because it does not meet the ΔC T  criterion; however, if the criterion had been set at 38, it would have met that level. Gene f is confirmed because it meets the ΔC T  criterion and matches the direction of expression associated with more youthful skin cell turnover per the literature data set on skin cell turnover. 
     Genes not chosen for the third subset of genes (gene h) may be considered for additional research based on secondary research factors  152 . 
     Turning to the testing-derived data example (actual Affymetrix data for salicin exposed tissue and data from RT-rt-PCR testing), Table 6 (see also,  FIG. 7  at  770 ) illustrates one embodiment of a functional youth gene assembly selected for the skin attribute “skin structure.” Table 6 thus represents a comparative analysis of the results of Table 5 and Table 4, by confirmation of direction of regulation criterion and the ΔC T  criterion applied to the hypothetical data. Thus, a gene appears in Table 6, only if (a) it appears in Table 4 and the data of Table 5 confirm that it have a strong-enough level of expression based on the ΔC T  criterion and that the data of Table 5 do not show a regulation direction that contradicts the more youthful direction that was the basis for inclusion in Table 4, or (b) although not in Table 4, it was added to the candidate list for secondary reasons and the result of the RT-rt-PCR testing provides strong evidence that it should be added, including a regulation direction that is consistent the more youthful direction and a strong ΔC T  value, exceeding the ΔC T  criterion. 
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 6 
               
               
                   
               
               
                 Gene 
                 Gene 
                   
                   
                   
                   
               
               
                 Symbol 
                 Description 
                 Direction 
                 p-value 
                 Log10RG 
                 Reference 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 FOXO1 
                 forkhead 
                 up 
                 0.036848433 
                 0.238284357 
                 Am J Physiol Cell 
               
               
                   
                 box O1 
                   
                   
                   
                 Physiol 292: 
               
               
                   
                   
                   
                   
                   
                 C850-C856, 2007 
               
               
                 ITGB1 
                 integrin, beta 1 
                 up 
                 0.01401738 
                 0.093562957 
                 Br J Dermatol. 
               
               
                   
                   
                   
                   
                   
                 2003 
               
               
                   
                   
                   
                   
                   
                 Apr; 148(4): 770-8 
               
               
                 FN1 
                 fibronectin 1 
                 up 
                 0.027437424 
                 0.241122656 
                 Exp Cell Res. 
               
               
                   
                   
                   
                   
                   
                 1990 
               
               
                   
                   
                   
                   
                   
                 Nov; 191(1): 8-13 
               
               
                 SOD2 
                 superoxide 
                 up 
                 0.027437424 
                 0.302541956 
                 Journal of 
               
               
                   
                 dismutase 2, 
                   
                   
                   
                 Investigative 
               
               
                   
                 mitochondrial 
                   
                   
                   
                 Dermatology 
               
               
                   
                   
                   
                   
                   
                 (1994) 102, 476-480 
               
               
                 COL4A1 
                 Collagen Type 
                 up 
                 0.016310135 
                 0.208638283 
                 J Clin Invest. 1989 
               
               
                   
                 4 Alpha 1 
                   
                   
                   
                 March; 83(3): 
               
               
                   
                   
                   
                   
                   
                 791-795 
               
               
                 S100A8 
                 S100 calcium 
                 down 
                 0.001131397 
                 −0.63072926 
                 Arch Dermatol 
               
               
                   
                 binding 
                   
                   
                   
                 Res. 2009 
               
               
                   
                 protein A8 
                   
                   
                   
                 Aug; 301(7): 523-9. 
               
               
                   
                 (calgranulim 
                   
                   
                   
                 Epub 2009 May 
               
               
                   
                 A or cystatin 
                   
                   
                   
                 23. 
               
               
                   
                 A) 
               
               
                   
               
            
           
         
       
     
     The RT-rt-PCR methodology permits not only a second reading on the activity of genes that have met the criteria for a gene assembly in steps  102 - 134 , it provides an opportunity to test a gene that has not met these criteria, but might meet certain secondary research factors that suggest it may be of interest for a particular gene assembly. Secondary research factors may suggest further testing of genes that have a high fold change without any literature support for their relevance in skin tissue, genes associated with anti-aging mechanisms of action but not thought of as skin-related, or genes that are strongly supported by literature as having an effect on skin aging, but not achieving a significant fold change cutoff in testing as described in steps  102 - 134  of the simplified example. Genes with significant fold change values that are not identified in the literature as having a favorable impact on a skin attribute may be considered for additional research. In the simplified sample set of genes, gene h not chosen for the third subset of genes is considered for additional research based on secondary research factors  152 . See  FIGS. 1G-1K . For example, genes such as Klotho (KL) which have published anti-aging benefits in mice may be of interest. Genes such as these may provide insights on identifying and discovering new novel pathways in the skin aging process. 
     A favorable impact on a skin attribute is a biologically relevant change that establishes a state of an attribute more similar to the non-aged state of the attribute. For example, a favorable impact is recognized when an agent that is applied to the skin results in a more youthful appearance. The present system and method may be used to extend more efficiently the search for agents that cause a favorable impact. For example if the potential of a possible useful agent needs basic exploration, it can be run through the entire method of  FIGS. 1A-1K  to see how the resulting functional youth gene assembly compares to that of other agents. Using more than one agent to execute the method decreases possible agent bias resulting from using a singular agent to determine a functional youth gene assembly. 
     For greater efficiency, once researchers have confidence in one or more functional youth gene assemblies, testing of an agent my be done by omitting full genome microarray studies and using only more limited studies for the genes included in one of more of the functional youth gene assemblies. 
     One outcome of using the entire method described to screen agents that trigger a relevant change in gene expression is to identify genes for further study, even if they are not yet reported in the literature. These may be genes that are not currently associated with any biochemical pathway associated with skin, but may be in the future, as there are advances in technology and further research studies. These genes may optionally be added to an appropriate functional youth gene assembly. 
     Genes with non-skin related anti-aging mechanisms of action may be subjected to further testing to determine the gene&#39;s effect, if any, on skin aging. For example, scientific literature suggests that the β-klotho gene appears to be involved in the aging process. See, U.S. Pat. No. 7,537,903. 
     Genes that are supported by literature as having an effect on skin aging, but not achieving the biologically relevant fold change cutoff in micro-array testing may be subjected to another round of micro-array testing with different concentrations of the agent or with different anti-aging agent(s). 
     In some embodiments, the functional youth gene assemblies, the groups of genes identified for a skin attribute in genome-wide microarray tests, are optionally refined based on the results from the RT-rt-PCR experiments. If the literature discloses that a gene with “up” regulation results in better skin structure, and the RT-rt-PCR data shows “down” regulation for this gene, the gene may be set aside for possible further research at a later date. Alternately, if the literature discloses a gene with “up” regulation results in better skin structure, and the RT-rt-PCR data shows “up” regulation for this gene, then the gene may be added to the functional youth gene assembly. 
     After application of secondary research factors, more genes are optionally added into one or more functional youth gene assembly  154 . 
     A method that utilizes the results of the groups of genes, the functional youth gene assemblies, may be used to guide further research on aging of the skin. 
     Data Processing System Implementation 
     Data Sets 
     As discussed above,  FIG. 7  shows a schematic diagram of a system for carrying out the method disclosed, including data set developed and used as the method proceeds and the test equipment used to develop various sets of data from the tissue samples of the skin models. This system can now be further explained with reference to  FIG. 8 , that shows the data sets used in the system and method and how they are transformed into the functional youth gene assemblies. The system  700  broadly comprises a data processing system  710  with a CPU and memory, in which there is an operating system  712 , and the test equipment that develops data, including a full genome microarray device  780  and a PCR testing device  790 . The test equipment is supplied, and the materials to be tested, prepared per the supplier&#39;s instructions, include the samples of agent exposed skin model  782  and the non-exposed skin model  784 . 
     The data processing system  710  includes a database  730  that receives and stores the data used in the process described above. The process applications modules  720  execute, including statistics modules  722  and applications using user selected process parameters  724  to perform the flowchart (see  FIGS. 1A-1K ) processes. The process applications modules  720  access the database  730  using suitable database management protocols  732 . 
     The database stores the various data sets involved including the full genome data sets  750   a ,  750   b  developed at the full genome microarray device  780 , the calculated ratio data  750   c  and the fold criterion result data set  752 , developed by application of the fold change criterion. The database  730  also stores the pathway criterion data set  754  that identifies the association between a gene and one or more biological pathways and the intersection dataset  755  resulting from the intersection of the fold criterion result data set  752  and the pathway criterion data set  754 . The database  730  further stores the skin attribute focus data sets  756  that defines the association between a particular skin attribute that is a under study and genes that are associated with that attribute in the literature. After the intersection analysis of a particular skin attribute focus data set  756  with the skin attribute/regulation direction data and the fold criterion result data  752  (which includes determining alignment of the more youthful regulation direction for the particular biochemical pathways), the developed skin attribute subset  758 , representing a preliminary functional youth gene assembly for a particular skin attribute is stored in database  730 . 
     The data processing system&#39;s database  730  also receives and holds data relevant to the PCR testing and results of the confirmation analysis for the preliminary functional youth gene assembly. This includes storing the PCR candidate data  760 , i.e., the listing of the genes based on the preliminary functional youth gene assembly as supplemented with genes of secondary interest that will be subject to PCR testing under the cycle level criterion or other parameters used in the analysis of the PCR testing data. After the PCR tests have been run, the database  730  receives the PCR cycle data  762  including the associated up/down regulation direction observed from testing. From the PCR cycle data set  762 , the processing applications  724  derives the Final Attribute Data  770 ,  772  for one or more skin attributes. 
     As noted, stored in memory are the process application modules  720 . These are software generally in two categories. A first category is the conventional statistical analysis programs  722 , such as GeneSpring GX software (version 10) or other commercial software to perform a parametric t-test with a Benjamini and Hochberg false discovery rate correction. The StatMiner (Version 3) software may be used for analysis of the PCR data. The second category is the flowchart process applications that implement the analysis and steps discussed above and shown in  FIGS. 1A-1K . The process application modules  720  that are custom-developed may be written in any suitable language, such as C++, or other languages suitable for the analysis and steps discussed above and shown in  FIGS. 1A-1K . 
       FIG. 8  shows in simplified form the progression of data sets as the system proceeds to execute the method. In particular,  FIG. 8  traces the test results data sets  802 ,  804 ,  806 ,  810 ,  812  and shows the effect of the literature-based data sets and user selected parameters.  FIG. 8  shows how the data sets stemming from the full genome microarray data  802 ,  804 ,  806 ,  808  and data set  810 , stemming from the PCR instrument, are modified to obtain a confirmed skin attribute subset  812 , that is a function youth gene assembly by the data processing steps outlined in the simplified hypothetical example of  FIGS. 1A-1K .  FIG. 8  also references Tables 1-6 that are based on actual whole genome microarray and PCR testing. 
     Screening Method 
     While a primary use of the present methodology is to develop the functional youth gene assemblies that provide a focus for further gene-level research on skin attributes, the methodology may also be used to screen agents for effectiveness to reduce skin aging. An agent may be chosen for testing to assess the efficacy of the particular agent and to explore the genetic pathway focus of its action. Known anti-aging agents have shown significantly different levels of gene expression in genes associated with a plurality of biochemical pathways of the skin. A screening method of this type could significantly lessen the number of costly and lengthy in vivo testing procedures done on many anti-aging product candidates. For example, many consumer studies on facial anti-aging products run for at least 12 weeks. Provided a reliable functional youth gene assembly is identified, testing the effects of an agent on the biochemical pathways associated with particular genes provides a focused way to develop data on the action of the an anti-aging candidate on a much shorter time frame and provides quantitative data for comparison to other agents. 
     A screening approach may be used to assess the likelihood of another agent working well in an anti-aging skin care product. A new agent triggering levels of gene expression to a functional youth gene assembly similar to or superior to a known skin anti-aging agent may be considered for further study, while a new agent that does not trigger similar levels of gene expression in those genes in a functional youth gene assembly may not be considered for further research investment. 
     The screening method may also be used for improving the effective properties of existing anti-aging skin care products, selecting new anti-aging ingredients for products, and selecting blends of anti-aging ingredients for products. From an understanding of which genes and which biochemical pathways have skin anti-aging effects, the properties of an agent as a promoter of a biochemical pathway associated with more youthful appearance or an inhibitor of a biochemical pathway associated with less youthful appearance may be improved. Using the screening method on many possible agent candidates instead of time-consuming clinical testing on fewer agent candidates is both a time-efficient and cost-effective way of performing research and development. The method helps to provide consumers with anti-aging products based on the most recent scientific research. 
     Other agents and agent blends including, for example, arNOX inhibitory agents derived from plant extracts may be tested. The plant for extract is optionally selected from broccoli, shitake, coleus, rosemary, lotus, artichoke, sea rose tangerine,  Oenothera biennis , astaxanthin, red orange,  Schisandra chinensis, Lonicera, Fagopyrum , carrot,  Narcissus tazetta  or olive. The arNOX inhibitory agents optionally include salicylates, for example, salicin, salicylic acid, salicyl hydroxamate, derivatives or combinations thereof. 
     While one embodiment of the present methodology is to develop the functional youth gene assemblies that provide a focus for further gene-level research on skin attributes, when the methodology is used to screen agents for effectiveness to reduce skin aging, it can assist in the formulation of a composition to reduce skin aging. Once an agent has been identified in testing to have efficacy as a promoter of a biochemical pathway associated with more youthful appearance or an inhibitor of a biochemical pathway associated with less youthful appearance for at least one skin attribute, that agent can be a candidate for an active ingredient in a composition to reduce skin aging. Provided a reliable functional youth gene assembly has been identified and efficacy of an agent on the biochemical pathways associated with particular genes in that assembly has been found, the composition can be targeted specifically to improvement of the skin attribute associated with that functional youth gene assembly. A composition can be formulated that addresses multiple skin attributes, once effective agents for the multiple skin attributes are found by the process and system disclosed herein. A composition can also include a pharmaceutically acceptable carrier. A pharmaceutical acceptable carrier refers to a carrier medium that does not interfere with the effectiveness of the biological activity of the active ingredient, is chemically inert, and is not toxic to the patient to whom it is administered. The type of the carrier may include powders, emollients, lotions, creams, liquids and the like. 
     Thus, the understanding of which genes and which biochemical pathways have skin anti-aging effects and the properties of an agent as a promoter of a biochemical pathway associated with more youthful appearance or an inhibitor of a biochemical pathway associated with less youthful appearance is improved by the methods discussed herein, this understanding can be translated into compositions that are directed to one or more skin attributes associated with a functional youth gene assembly. It is expected that agents showing an anti-aging efficacy will be derived from broccoli, shitake, coleus, rosemary, lotus, artichoke, sea rose tangerine,  Oenothera biennis , astaxanthin, red orange,  Schisandra chinensis, Lonicera, Fagopyrum , carrot,  Narcissus tazetta  or olive. They also may be derived from arNOX inhibitory agents that include salicylates, for example, salicin, salicylic acid, salicyl hydroxamate, derivatives or combinations thereof. These agents and their derivatives may then be deployed in skin anti-aging formulations with a sound basis in research at the genetic level. 
     In Vivo Testing 
     Evaluation of Composition Including Anti-Aging Agent 
     For further confirmation of the effects of an agent that is viewed as regulating in a youthful direction the pathways of a functional youth gene assembly for a skin attribute, consumer clinical studies may be conducted with a skin care product including the anti-aging agent tested with in vitro methods. Clinical studies with trained observation and measurement of skin parameters confirm changes in particular skin aging attributes as regulated by a particular functional youth gene assembly. 
     After a group of genes are selected as a functional youth gene assembly, in vitro studies including the assay methods discussed above, are used to screen agent candidates and limit the amount of in vivo studies used in product development. 
     A skin care product, ageLOC® Future Serum, including 0.5% salicin is the finished formulation used for evaluation in clinical testing. The ageLOC® Future Serum is commercially available from Nu Skin Enterprises, Inc. (Provo, Utah). 
     Twenty-nine out of thirty subjects completed the clinical study. Table 7 summarized the demographics of the study participants. 
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 Study Participant&#39;s demographic summary. 
               
            
           
           
               
               
               
               
            
               
                   
                 Demographic 
                   
                 All Subjects 
               
               
                   
                 Summary 
                   
                 (n = 30) 
               
               
                   
                   
               
               
                   
                 Age (Years) 
                 Mean Age ± Standard 
                 56.06 ± 7.76 
               
               
                   
                   
                 Deviation 
               
               
                   
                   
                 Minimum Age 
                 40.44 
               
               
                   
                   
                 Maximum Age 
                 70.28 
               
               
                   
                 Ethnicity 
                 Caucasian 
                   50% 
               
               
                   
                   
                 Asian 
                   50% 
               
               
                   
                 Fitzpatrick 
                 I 
                  5.10% 
               
               
                   
                 Skin Type 
                 II 
                 42.40% 
               
               
                   
                   
                 III 
                 47.50% 
               
               
                   
                 Demographic 
                   
                 All Subjects 
               
               
                   
                 Summary 
                   
                 (n = 30) 
               
               
                   
                   
               
            
           
         
       
     
     The Fitzpatrick skin classification is based on the skin&#39;s unprotected response to the first 30 to 45 minutes of sun exposure after a winter season without sun exposure: 
     I—Always burns easily; never tans; II—Always burns easily; tans minimally; III—Burns moderately; tans gradually; IV—Burns minimally; always tans well; V—rarely burns; tans profusely; VI—Never burns; deeply pigmented. 
     Clinical Procedures 
     At baseline (Visit 1), each prospective subject completed an Eligibility and Health Questionnaire, and read and signed a Confidentially Agreement, a Photography Release Form and an Informed Consent Agreement. Each subject was explained the type of study, the detailed procedures and materials to be tested, along with any known adverse reactions that may result from participation. Subjects arrived at the clinic having refrained from applying any moisturizer to the face at least 3 to 5 days prior to visit and having cleansed the face to remove all makeup at least 30 minutes prior to visit. Subjects were consequently not allowed to use any other topical cosmeceuticals, topical retinoid, or moisturizers during the 12 week duration of the study. 
     Subjects used the study product on their face twice daily for 12 weeks. Ordinal grading on a 9-point scale (0=none, 1-3=mild, 4-6=moderate, 7-9=severe) of facial fine lines, mottled pigmentation, uneven skin tone, tactile roughness, global firmness appearance, jaw-line contour, radiance and overall appearance was performed by investigator at baseline, week 1, week 4, week 8 and week 12. 
     Digital high-resolution photography was performed on the front, right and left sides of the face. Each image was taken while the subject&#39;s eyes were open. Each subject&#39;s baseline photograph was compared to each post-baseline photograph to ensure consistent placement and lighting. Color standards were imaged prior to each study visit. 
     Corneometry measurements were taken on each subject&#39;s left ocular bone (in line with pupil) to measure the moisture content of the stratum corneum. 
     Ultrasound measurements were taken on the left side of each subject&#39;s face to measure density of the facial skin in the crow&#39;s feet area. Measurements were taken with the probe oriented perpendicular to the body axis while the subjects were resting supine on a padded patient table. 
     A single cutometer measurement was taken on the right side of the subject&#39;s face, in line with the corner of the eye and the edge of the nostril, to measure the extensibility of the skin. 
     All clinical and corneometer measurements and evaluations were taken at baseline, week 1 (visit 2), week 4 (visit 3), week 8 (visit 4) and week 12 (visit 5). Ultrasound and cutometer measurements and evaluations were taken at baseline, week 4 (visit 3), week 8 (visit 4) and week 12 (visit 5). Completed patient&#39;s diaries were reviewed for compliance at each visit. 
     Biostatistics 
     Mean clinical grading and instrumentation scores at each visit were statistically compared to baseline scores using paired t-test. Changes from baseline were considered significant at the p≦0.05 level. Mean percent change from baseline and incidence of positive responders were calculated for all attributes. Comparisons, based on the average from baseline, were made between the test materials using analysis of variance (ANOVA). 
     Results 
     Twenty-nine of thirty subjects successfully completed the study with one subject unable to complete due to personal reasons. Compliance assessments indicated that subjects were following test formulation use instructions. 
       FIG. 2  depicts the result of clinical investigator grading showing a breakdown of the different sub-categories of wrinkles evaluated against baseline at week 1, week 4, week 8 and week 12 time points. 
       FIG. 3  depicts the result of clinical investigator grading showing change of each investigated parameter (except wrinkles) against baseline at week 1, week 4, week 8 and week 12 time points. 
     The clinical investigator&#39;s facial assessments indicated a statistically significant improvement in facial fine lines, tactile roughness, pore size, radiance and overall appearance at week 1 time point (P≦0.05). All of the benefits continued into weeks 4, 8 and 12. Statistically significant improvement in mottled pigmentation, global firmness, sub-categories of wrinkles and jaw-line contour was recorded at week 4 time point (P≦0.05) and continued through to week 12. 
     Corneometer measurements indicated statistical improvement in hydration at week 1 time point (P≦0.05). This improvement continued through week 8. Hydration of the stratum corneum was decreased significantly (P≦0.05) at the week 12 time point. 
       FIG. 4  depicts the result of corneometer grading showing moisture content of the stratum corneum, at week 1, week 4, week 8 and week 12 time points. 
     Cutometer measurements indicated statistical improvement in extensibility of the skin at week 12 time point (P≦0.05). 
       FIG. 5  depicts the results of cutometer readings showing extensibility measurements of the skin, evaluated against baseline at week 4, week 8 and week 12 time points. 
     Ultrasound measurements indicated statistical improvement in density of the skin at week 4 time point (P≦0.05). This improvement continued through week 12. 
       FIG. 6  depicts the result of density evaluation from ultrasound, against baseline at week 4, week 8 and week 12 time points. 
     No tolerability issues related to erythema, edema and scaling were observed by the investigator. Three subjects reported a slight stinging at week 8 (P≦0.05) and slight itching at week 12 (P≦0.05). 
     
       
         
           
               
             
               
                 TABLE 8 
               
             
            
               
                   
               
               
                 Mean values of Clinical Grading and Instrumentation 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                 Base- 
                   
                   
                   
                   
               
               
                   
                   
                 line 
                 Week 1 
                 Week 4 
                 Week 8 
                 Week 12 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                 Mean 
                 Mean 
                 % Change 
                 Mean 
                 % Change 
                 Mean 
                 % Change 
                 Mean 
                 % Change 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Crows Feet 
                 Wrinkles 
                 3.29 
                 3.21 
                   
                 (−0.5%) 
                 3.00 
                 
                   
                 
                 (−8.9%) 
                 2.71 
                 
                   
                 
                 (−17.8%) 
                 2.48 
                 
                   
                 
                 (−24.6%) 
               
               
                 Under-Eye  
                 Wrinkles 
                 3.19 
                 3.07 
                   
                 (−1.7%) 
                 2.79 
                 
                   
                 
                 (−12.4%) 
                 2.55 
                 
                   
                 
                 (−20.0%) 
                 2.24 
                 
                   
                 
                 (−29.7%) 
               
               
                 Area 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Cheek 
                 Wrinkles 
                 2.41 
                 2.29 
                   
                 (−1.5%) 
                 2.26 
                 
                   
                 
                 (−6.4%) 
                 2.12 
                 
                   
                 
                 (−12.1%) 
                 2.02 
                 
                   
                 
                 (−16.4%) 
               
               
                 Face 
                 Fine Lines  
                 4.29 
                 4.14 
                 
                   
                 
                 (−3.7%) 
                 3.76 
                 
                   
                 
                 (−12.4%) 
                 3.47 
                 
                   
                 
                 (−19.2%) 
                 3.10 
                 
                   
                 
                 (−27.7%) 
               
               
                   
                 (Overall) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 Mottled 
                 5.05 
                 5.05 
                   
                 (−0.7%) 
                 4.74 
                 
                   
                 
                 (−6.1%) 
                 4.57 
                 
                   
                 
                 (−9.5%) 
                 4.33 
                 
                   
                 
                 (−14.3%) 
               
               
                   
                 Pigmentation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 Uneven Skin  
                 5.05 
                 5.05 
                   
                 (−0.7%) 
                 4.74 
                 
                   
                 
                 (−6.1%) 
                 4.57 
                 
                   
                 
                 (−9.5%) 
                 4.34 
                 
                   
                 
                 (−13.9%) 
               
               
                   
                 Tone 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 Tactile  
                 3.48 
                 2.41 
                 
                   
                 
                 (−30.7%) 
                 2.02 
                 
                   
                 
                 (−42.0%) 
                 1.43 
                 
                   
                 
                 (−58.9%) 
                 0.98 
                 
                   
                 
                 (−71.7%) 
               
               
                   
                 Roughness/ 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 Smoothness 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 Global  
                 5.03 
                 5.04 
                   
                 (0.3%) 
                 4.86 
                 
                   
                 
                 (−3.4%) 
                 4.64 
                 
                   
                 
                 (−7.8%) 
                 4.48 
                 
                   
                 
                 (−10.9%) 
               
               
                   
                 Firmness 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 Appearance 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 Jawline  
                 5.16 
                 5.14 
                 . 
                 (0.0%) 
                 5.10 
                   
                 (−1.0%) 
                 4.95 
                 
                   
                 
                 (−4.0%) 
                 4.74 
                 
                   
                 
                 (−8.0%) 
               
               
                   
                 Contour 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 Pore Size 
                 4.41 
                 4.30 
                 
                   
                 
                 (−2.4%) 
                 4.05 
                 
                   
                 
                 (−8.2%) 
                 3.86 
                 
                   
                 
                 (−12.5%) 
                 3.71 
                 
                   
                 
                 (−16.0%) 
               
               
                   
                 Radiance 
                 5.81 
                 5.20 
                 
                   
                 
                 (−11.0%) 
                 4.90 
                 
                   
                 
                 (−15.7%) 
                 4.72 
                 
                   
                 
                 (−18.6%) 
                 4.59 
                 
                   
                 
                 (−21.0%) 
               
               
                   
                 Overall  
                 5.47 
                 5.21 
                 
                   
                 
                 (−4.2%) 
                 4.91 
                 
                   
                 
                 (−10.0%) 
                 4.67 
                 
                   
                 
                 (−14.5%) 
                 4.50 
                 
                   
                 
                 (−17.6%) 
               
               
                   
                 Appearance 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Left Ocular  
                 Corneometer 
                 56.49 
                 60.54  
                 
                   
                 
                 (7.3%) 
                 62.49 
                 
                   
                 
                 (10.6%) 
                 63.91 
                 
                   
                 
                 (13.1%) 
                 52.23 
                 
                   
                 
                 (−7.5%) 
               
               
                 Bone 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Cutometer 
                 Extensibility 
                 1.15 
                 N/A 
                 N/A 
                 1.17 
                   
                 (1.8%) 
                 1.17 
                   
                 (1.3%) 
                 1.26 
                 
                   
                 
                 (9.6%) 
               
               
                 Ultrasound 
                 Density 
                 18.55 
                 N/A 
                 N/A 
                 21.38 
                 
                   
                 
                 (15.2%) 
                 23.52 
                 
                   
                 
                 (26.7%) 
                 25.21 
                 
                   
                 
                 (35.8%) 
               
               
                   
               
               
                    Indicates a statistically significant (p ≦ 0.05) increase compared to Baseline 
               
               
                    Indicates a statistically significant (p ≦ 0.05) decrease compared to Baseline 
               
            
           
         
       
     
     All references disclosed herein, whether patent or non-patent, are hereby incorporated by reference as if each was included at its citation, in its entirety. 
     Although the present disclosure has been described with a certain degree of particularity, it is understood the disclosure has been made by way of example, and changes in detail or structure may be made without departing from the spirit of the disclosure as defined in the appended claims.