Patent Publication Number: US-2022233611-A1

Title: Compositions and methods for promoting healthy neural development in an unborn baby

Description:
RELATED APPLICATION 
     This application claims a right of priority to and the benefit of U.S. Provisional Application No. 62/844,503, filed on May 7, 2019, which is hereby incorporated by reference herein in its entirety. 
    
    
     STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH 
     This invention was made with government support under Grant Numbers AI007323, GM106996, and DE025172, awarded by the National Institutes of Health. The government has certain rights in the invention. 
    
    
     BACKGROUND 
     Dysbiosis of the maternal gut microbiome, in response to environmental challenges such as infection, altered diet, and stress during pregnancy has been increasingly associated with abnormalities in offspring brain function and behavior. However, whether the maternal gut microbiome begins to exert its influences during critical periods of embryonic brain development remains poorly understood. 
     The intestinal microbiota is an important modulator of brain function and behavior, but further research is necessary to resolve whether there are prenatal critical periods during which the microbiome impacts the development of the nervous system. Various model organisms reared devoid of microbial colonization (germ-free, GF) or depleted of the gut microbiome (antibiotic-treated, ABX) exhibit altered neurophysiology and behavior compared to conventionally-colonized (specific pathogen-free, SPF) controls. Only a subset of phenotypes can be corrected by postnatal restoration of the microbiome, suggesting a role for the early life microbiome in regulating developmental processes that impact brain function and behavior during adulthood. Thus, methods of modifying the maternal microbiome, for example to compensate for a depleted maternal microbiome, prenatally (i.e., during gestation) are needed. 
     SUMMARY 
     In some aspects, methods of promoting healthy neural development in an unborn baby include administering to a maternal subject gestating the unborn baby a composition that comprises trimethylamine N-oxide (TMAO), 5-aminovalerate (5-AV), imidazole propionate (IP), hippurate (HIP), or a combination thereof. 
     In certain aspects, methods of reducing adverse effects of antibiotic treatment on an unborn baby in a pregnant subject include administering to the pregnant subject, conjointly with the antibiotic treatment, a composition comprising trimethylamine N-oxide (TMAO), 5-aminovalerate (5-AV), imidazole propionate (IP), hippurate (HIP), or a combination thereof. 
     In some aspects, methods of conditioning a female subject for fostering healthy neural development in offspring are disclosed. These methods include administering to the female subject a composition comprising trimethylamine N-oxide (TMAO), 5-aminovalerate (5-AV), imidazole propionate (IP), hippurate (HIP), or a combination thereof, e.g., in which the composition is administered at least once during a period that runs from the first day of an expected-but-missed menstruation to a day that is two months after that first day. In some embodiments of these aspects, the composition is administered at least once during a period that runs from the second day of the expected-but-missed menstruation to a day that is 10 to 60 days (e.g., 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 35, 36, 37, 38, 39, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60) after said second day. 
     These aspects have many embodiments. For example, in certain embodiments healthy neural development includes healthy tactile sensory development. In some embodiments, the composition includes 5-AV and IP. In certain embodiments, the composition includes TMAO. In certain embodiments, healthy neural development includes healthy thalamocortical axon growth. In some embodiments, healthy neural development includes healthy netrin-G1a+thalamocortical axogenesis. The maternal subject and the unborn baby are preferably mammals, most preferably primates, especially humans. 
     In particularly preferred embodiments, the maternal subject and the unborn baby are humans. In certain such embodiments, the method includes administering the composition at least once during the first trimester of the gestating maternal subject&#39;s gestation period. In some embodiments, the method includes administering the composition at least once during a period that runs from the start of the third week after conception to the end of the eighth week after conception. In certain embodiments, the method includes administering the composition at least once during a period that runs from the 17 th  day post conception (dpc) to the 52 nd  dpc. This period can be varied, for example, it can start from any of the following dpcs: 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 and end at any one of the following dpcs: 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 70, 80, 90, 100, 150, 200, 250. In some embodiments, the method includes administering the composition at least once during the second trimester of the gestating maternal subject&#39;s gestation period. In certain embodiments, the method comprises administering the composition at least once during the third trimester of the gestating maternal subject&#39;s gestation period. In some embodiments, the unborn baby is an offspring of the maternal subject. 
     In some aspects, methods of promoting healthy neural development in an unborn baby include administering to a maternal subject gestating the unborn baby a bacterial composition comprising bacteria of the order Clostridiales. In some such embodiments (e.g., of any aspect involving the use of, as well as other embodiments relating to the use of bacteria of the order Clostridiales herein), the bacteria of the order Clostridiales include bacteria of the family Lachnospiraceae, family Ruminococcaceae, family Clostridiaceae, or a combination thereof. In certain embodiments, the bacteria of the order Clostridiales include bacteria of the genus  Clostridium , genus Dehalobacterium, genus  Ruminococcus , genus  Coprococcus , genus  Dorea , genus  Oscillospira , or a combination thereof. In some embodiments, the bacteria of the order Clostridiales are spore-forming bacteria. 
     In certain embodiments (e.g., of any aspect involving the use of bacteria of the order Clostridiales), the method includes administering the bacterial composition at least once during the first trimester of the gestating maternal subject&#39;s gestation period. In some embodiments, the method further includes administering the bacterial composition at least once during the two-month period before said gestation period starts. In certain embodiments, the method further includes administering to the maternal subject a composition comprising trimethylamine N-oxide (TMAO), 5-aminovalerate (5-AV), imidazole propionate (IP), hippurate (HIP), or a combination thereof. 
     In certain aspects, methods of conditioning a female subject for bringing about offspring with healthy neural development are disclosed. These aspects include administering to the female subject a bacterial composition comprising spore-forming bacteria of the order Clostridiales, in which the bacterial composition is administered at least once during a two-month period that ends with the day of an expected or possible conception for the female subject. 
     In some aspects, methods of selecting a female subject for conditioning to foster healthy neural development in offspring are disclosed. These aspects include determining that a compound in a serum sample from the female subject, bacteria of the order Clostridiales in a fecal sample from the female subject, or both satisfy an applicable criterion, and selecting the female subject for conditioning to foster healthy neural development in offspring. The compound is 2-(4-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate sulfate; 3-indoxyl sulfate; 3-phenylpropionate (hydrocinnamate); 7-ketodeoxycholate; alpha-ketoglutaramate; alpha-muricholate; beta-muricholate; biotin; deoxycholate; hippurate; imidazole propionate; indolepropionate; N,N,N-trimethyl-5-aminovalerate; p-cresol sulfate; phenylpropionylglycine; pyrraline; stachydrine; taurodeoxycholate; taurohyodeoxycholic acid; trimethylamine N-oxide; ursodeoxycholate; or a combination thereof. The applicable criterion for the compound (or a combination of compounds) is for the compound to have a level in a serum sample from the female subject that is at most 10%, 20%, 30%, 40%, 50%, 60%, or 70% of its level in a control serum sample representative of a healthy female subject. The applicable criterion for the bacteria of the order Clostridiales is for them to have a total level in a fecal sample from the female subject that is at most 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 14%, 16%, 18%, or 20% of their total level in a control fecal sample representative of a healthy female subject. 
     In some embodiments of these aspects related to selecting a female subject, the methods further include administering to the female subject a composition that comprises trimethylamine N-oxide (TMAO), 5-aminovalerate (5-AV), imidazole propionate (IP), hippurate (HIP), or a combination thereof; a bacterial composition that comprises spore-forming bacteria of the order Clostridiales; or a combination thereof. 
     In certain embodiments of these aspects related to selecting a female subject, the compound is 3-indoxyl sulfate; biotin; hippurate; imidazole propionate; N,N,N-trimethyl-5-aminovalerate; pyrraline; stachydrine; trimethylamine N-oxide; or a combination thereof; and the bacteria of the order Clostridiales are bacteria of the genus  Clostridium , genus Dehalobacterium, genus  Ruminococcus , genus  Coprococcus , genus  Dorea , genus  Oscillospira , or a combination thereof. In some of these methods, liquid chromatography-mass spectrometry is used to determine a level for the compound. In some embodiments, 16S rDNA sequencing is used to determine a total level for the bacteria. 
     In certain embodiments disclosed herein, the unborn baby or offspring is a fetus more than eight weeks after conception. 
     In certain embodiments, the present invention provides methods comprising administering to a maternal subject gestating a fetus a composition comprising: a compound selected from trimethylamine-N-oxide (TMAO), N,N,N-trimethyl-5-aminovaleric acid (TMAV), imidazole propionic acid (IP), 3-indoxyl sulfuric acid (3-IS), hippuric acid (HIP), perfluorooctanesulfonic acid (PFOS), 3-sulfo-L-alanine, alpha-ketoglutaramic acid, 4-hydroxyglutamic acid, extoine, stachydrine, biotin, pyroglutamine, chiro-inositol, N1-methyl-2-pyridone-5-carboxamide, O-sulfo-L-tyrosine, 2′deoxyuridine, pyrraline, N-delta-acetylornithine, phenyl sulfuric acid, phenylacetylglycine, anserine, homostachydrine, serine, N1-methyl-4-pyridone-3-carboxamide, methyl glycopyranoside (alpha+beta), 3-carboxy-1-methylpyridin-1-ium, hypotaurine, 1,5-anhydroglucitol (1,5-AG), 1-oleoyl-2-linoleoyl-GPC (18:1/18:2), methionine, glutamine, malic acid, pantothenic acid, 5,6-dihydrouridine, ceramide (d18:1/17:0 d17:1/18.0) N6-methyllysine, allantoin, N2-acetyllysine, N-acetylglutamine, stearoylcarnitine (C18), arachidoylcarnitine (C20), arabitol, xylitol, 1-methylhistamine, xanthosine, xanthine, 1-ribosyl-imidazoleacetic acid, 5-methyl-2′-deoxycytidine, sphingomyelin (d18:0/20:0, d16:0/22:0), 1-methyl-4-imidazoleacetic acid, inosine 5′-monophosphoric acid (IMP), 1,2-distearoyl-GPC (18:0/18:0), 3-methylcytidine, pipecolate, N-stearoyl-sphingadienine (d18:2/18:0), homoserine, carnosine, 1-palmitoyl-GPI (16:0), 1-stearoyl-GPI (18:0), N6-succinyladenosine, 2′-deoxycytidine, stearoyl-docosahexaenoyl-glycerol (18:0/22:6), trigonelline (N′-methylnicotinate), hydroxyasparagine, gamma-glutamylglutamic acid, 2-palmitoylglycerol (16:0), ceramide (d18:1/17:0, d17:1/18:0), thiamin (Vitamin B1), N6-methyllysine, N6,N6-dimethyllysine, 3-hydroxy-3-methylglutaric acid, campesterol, allantoin, stachydrine, N2-acetyllysine, phenyllactic acid (PLA), gamma-glutamyltryptophan, N-palmitoyl-sphingosine (d18:1/16:0), O-sulfo-L-tyrosine, indolelactic acid, gamma-glutamylglutamine, N-acetylglucosamine 6-phosphoric acid, 1-oleoyl-GPS (18:1), 3-hydroxypalmitoylcarnitine, myo-inositol, behenoyl sphingomyelin (d18:1/22:0), maltotetraose, maltotriose, N-acetylglucosamine/N-acetylgalactosamine, N1-methyladenosine, uracil, 1-oleoyl-GPI (18:1), sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0), 3-ureidopropionic acid, 5-oxoproline, gamma-glutamyltyrosine, 1-(1-enyl-stearoyl)-GPE (P-18:0), cytidine 2′,3′-cyclic monophosphoric acid, 2′-deoxyguanosine 5′-monophosphoric acid (dGMP), thymidine, N6,N6,N6-trimethyllysine, 1-palmitoyl-GPC (16:0), 1-(1-enyl-palmitoyl)-GPE (P-16:0), N-stearoyl-sphinganine (d18:0/18:0), N-arachidoyl-sphingosine (d18:1/20:0), 3′-dephosphocoenzyme A, 5-hydroxylysine, arabonic acid/xylonic acid, 1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6), glutamine, 1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0), N-behenoyl-sphingadienine (d18:2/22:0), xylulose 5-phosphoric acid, 1-oleoyl-GPC (18:1), 1-stearoyl-GPE (18:0), glycerol 3-phosphoric acid, N-stearoyl-sphingosine (d18:1/18:0), 7-methylguanine, N2,N2-dimethylguanosine, N-acetylglutamine, methionine, pro-hydroxy-pro, dihydroxyacetone phosphoric acid (DHAP), 1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6), sphingomyelin (d18:1/20:0, d16:1/22:0), uric acid, adenylosuccinic acid, cystathionine, spermine, mannitol/sorbitol, 2-hydroxyadipic acid, N-palmitoyl-sphinganine (d18:0/16:0), sphingomyelin (d18:0/18:0, d19:0/17:0), sphingomyelin (d18:1/24:1, d18:2/24:0), alpha-hydroxyisovaleric acid, citrulline, ribulonic acid/xylulonic acid, succinylcarnitine (C4-DC), ceramide (d16:1/24:1, d18:1/22:1), hypoxanthine, 5,6-dihydrouridine, gamma-aminobutyric acid (GABA), oleoyl ethanolamide, choline, 1-palmitoyl-GPE (16:0), palmitoyl-linoleoyl-glycerol (16:0/18:2), ceramide (d18:2/24:1, d18:1/24:2), cholesterol, 2′-O-methylcytidine, nicotinamide riboside, pantothenic acid, pyridoxal, N-acetylaspartic acid (NAA), C-glycosyltryptophan, methionine sulfoxide, spermidine, 1-palmitoyl-2-oleoyl-GPG (16:0/18:1), lignoceroyl sphingomyelin (d18:1/24:0), desmosterol, N1-methylinosine, cytidine, N-acetyl-aspartyl-glutamic acid (NAAG), sedoheptulose, galactonic acid, cytidine 5′-monophospho-N-acetylneuraminic acid, glycerophosphoinositol, uridine, salicylic acid, N-acetylglutamic acid, gamma-glutamyl-epsilon-lysine, glycerophosphoserine, 1-stearoyl-2-oleoyl-GPE (18:0/18:1), beta-alanine, 5-methylcytidine, methylphosphoric acid, imidazole lactic acid, sedoheptulose-7-phosphoric acid, 1-palmitoyl-2-stearoyl-GPE (16:0/18:0), guanosine 5′-diphosphoric acid (GDP), 3-ureidoisobutyric acid, tryptophan, isoleucine, methyl succinic acid, S-adenosylmethionine (SAM), taurine, gamma-glutamylthreonine, arabitol/xylitol, erythronic acid, fumaric acid, stearoylcarnitine (C18), deoxycarnitine, cytidine 5′-diphosphocholine, 1-stearoyl-2-arachidonoyl-GPC (18:0/20:4), 1-stearoyl-2-arachidonoyl-GPI (18:0/20:4), glycerophosphoglycerol, N6-carbamoylthreonyladenosine, flavin adenine dinucleotide (FAD), 2-oxoarginine, lactic acid, gulonic acid, phenylalanine, 3-(4-hydroxyphenyl)lactic acid, 2-hydroxyglutaric acid, palmitoleoyl ethanolamide, 1-palmitoyl-2-stearoyl-GPC (16:0/18:0), 1-stearoyl-2-oleoyl-GPC (18:0/18:1), palmitoyl-oleoyl-glycerol (16:0/18:1), betaine, N-acetylneuraminic acid, malic acid, phosphoethanolamine, 1-myristoyl-2-arachidonoyl-GPC (14:0/20:4), beta-citrylglutamic acid, 1-methylhistidine, leucine, ethylmalonic acid, prolylglycine, stearoyl-arachidonoyl-glycerol (18:0/20:4), orotidine, 5-(galactosylhydroxy)-L-lysine, N-acetylglucosaminylasparagine, eicosenoylcarnitine (C20:1), cytidine-5′-diphosphoethanolamine, glycosyl-N-stearoyl-sphingosine (d18:1/18:0), palmitoyl dihydrosphingomyelin (d18:0/16:0), sphingosine, inosine, guanosine 5′-monophosphoric acid (5′-GMP), dimethylglycine, N-acetylalanine, aspartic acid, creatine, ribitol, 2-methylcitric acid/homocitric acid, arachidoylcarnitine (C20), S-methylglutathione, 1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6), stearoyl sphingomyelin (d18:1/18:0), nicotinamide, N-formylmethionine, UDP-N-acetylglucosamine/galactosamine, glucoronic acid, 1,2-dipalmitoyl-GPE (16:0/16:0), pseudouridine, alanine, glutamic acid, 1-myristoyl-2-palmitoyl-GPC (14:0/16:0), 1,2-dipalmitoyl-GPC (16:0/16:0), 1-palmitoyl-2-oleoyl-GPC (16:0/18:1), sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1), glycerophosphoethanolamine, 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1), UDP-glucuronic acid, and 1-methylnicotinamide, or a salt thereof, or a combination thereof; and/or one or more bacterial species found in a maternal microbiome. 
     In certain embodiments, the present invention provides methods comprising administering to a female subject a composition comprising: a compound selected from trimethylamine-N-oxide (TMAO), N,N,N-trimethyl-5-aminovaleric acid (TMAV), imidazole propionic acid (IP), 3-indoxyl sulfuric acid (3-IS), hippuric acid (HIP), perfluorooctanesulfonic acid (PFOS), 3-sulfo-L-alanine, alpha-ketoglutaramic acid, 4-hydroxyglutamic acid, extoine, stachydrine, biotin, pyroglutamine, chiro-inositol, N1-methyl-2-pyridone-5-carboxamide, O-sulfo-L-tyrosine, 2′deoxyuridine, pyrraline, N-delta-acetylornithine, phenyl sulfuric acid, phenylacetylglycine, anserine, homostachydrine, serine, N1-methyl-4-pyridone-3-carboxamide, methyl glycopyranoside (alpha+beta), 3-carboxy-1-methylpyridin-1-ium, hypotaurine, 1,5-anhydroglucitol (1,5-AG), 1-oleoyl-2-linoleoyl-GPC (18:1/18:2), methionine, glutamine, malic acid, pantothenic acid, 5,6-dihydrouridine, ceramide (d18:1/17:0 d17:1/18.0) N6-methyllysine, allantoin, N2-acetyllysine, N-acetylglutamine, stearoylcarnitine (C18), arachidoylcarnitine (C20), arabitol, xylitol, 1-methylhistamine, xanthosine, xanthine, 1-ribosyl-imidazoleacetic acid, 5-methyl-2′-deoxycytidine, sphingomyelin (d18:0/20:0, d16:0/22:0), 1-methyl-4-imidazoleacetic acid, inosine 5′-monophosphoric acid (IMP), 1,2-distearoyl-GPC (18:0/18:0), 3-methylcytidine, pipecolate, N-stearoyl-sphingadienine (d18:2/18:0), homoserine, carnosine, 1-palmitoyl-GPI (16:0), 1-stearoyl-GPI (18:0), N6-succinyladenosine, 2′-deoxycytidine, stearoyl-docosahexaenoyl-glycerol (18:0/22:6), trigonelline (N′-methylnicotinate), hydroxyasparagine, gamma-glutamylglutamic acid, 2-palmitoylglycerol (16:0), ceramide (d18:1/17:0, d17:1/18:0), thiamin (Vitamin B1), N6-methyllysine, N6,N6-dimethyllysine, 3-hydroxy-3-methylglutaric acid, campesterol, allantoin, stachydrine, N2-acetyllysine, phenyllactic acid (PLA), gamma-glutamyltryptophan, N-palmitoyl-sphingosine (d18:1/16:0), O-sulfo-L-tyrosine, indolelactic acid, gamma-glutamylglutamine, N-acetylglucosamine 6-phosphoric acid, 1-oleoyl-GPS (18:1), 3-hydroxypalmitoylcarnitine, myo-inositol, behenoyl sphingomyelin (d18:1/22:0), maltotetraose, maltotriose, N-acetylglucosamine/N-acetylgalactosamine, N1-methyladenosine, uracil, 1-oleoyl-GPI (18:1), sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0), 3-ureidopropionic acid, 5-oxoproline, gamma-glutamyltyrosine, 1-(1-enyl-stearoyl)-GPE (P-18:0), cytidine 2′,3′-cyclic monophosphoric acid, 2′-deoxyguanosine 5′-monophosphoric acid (dGMP), thymidine, N6,N6,N6-trimethyllysine, 1-palmitoyl-GPC (16:0), 1-(1-enyl-palmitoyl)-GPE (P-16:0), N-stearoyl-sphinganine (d18:0/18:0), N-arachidoyl-sphingosine (d18:1/20:0), 3′-dephosphocoenzyme A, 5-hydroxylysine, arabonic acid/xylonic acid, 1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6), glutamine, 1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0), N-behenoyl-sphingadienine (d18:2/22:0), xylulose 5-phosphoric acid, 1-oleoyl-GPC (18:1), 1-stearoyl-GPE (18:0), glycerol 3-phosphoric acid, N-stearoyl-sphingosine (d18:1/18:0), 7-methylguanine, N2,N2-dimethylguanosine, N-acetylglutamine, methionine, pro-hydroxy-pro, dihydroxyacetone phosphoric acid (DHAP), 1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6), sphingomyelin (d18:1/20:0, d16:1/22:0), uric acid, adenylosuccinic acid, cystathionine, spermine, mannitol/sorbitol, 2-hydroxyadipic acid, N-palmitoyl-sphinganine (d18:0/16:0), sphingomyelin (d18:0/18:0, d19:0/17:0), sphingomyelin (d18:1/24:1, d18:2/24:0), alpha-hydroxyisovaleric acid, citrulline, ribulonic acid/xylulonic acid, succinylcarnitine (C4-DC), ceramide (d16:1/24:1, d18:1/22:1), hypoxanthine, 5,6-dihydrouridine, gamma-aminobutyric acid (GABA), oleoyl ethanolamide, choline, 1-palmitoyl-GPE (16:0), palmitoyl-linoleoyl-glycerol (16:0/18:2), ceramide (d18:2/24:1, d18:1/24:2), cholesterol, 2′-O-methylcytidine, nicotinamide riboside, pantothenic acid, pyridoxal, N-acetylaspartic acid (NAA), C-glycosyltryptophan, methionine sulfoxide, spermidine, 1-palmitoyl-2-oleoyl-GPG (16:0/18:1), lignoceroyl sphingomyelin (d18:1/24:0), desmosterol, N1-methylinosine, cytidine, N-acetyl-aspartyl-glutamic acid (NAAG), sedoheptulose, galactonic acid, cytidine 5′-monophospho-N-acetylneuraminic acid, glycerophosphoinositol, uridine, salicylic acid, N-acetylglutamic acid, gamma-glutamyl-epsilon-lysine, glycerophosphoserine, 1-stearoyl-2-oleoyl-GPE (18:0/18:1), beta-alanine, 5-methylcytidine, methylphosphoric acid, imidazole lactic acid, sedoheptulose-7-phosphoric acid, 1-palmitoyl-2-stearoyl-GPE (16:0/18:0), guanosine 5′-diphosphoric acid (GDP), 3-ureidoisobutyric acid, tryptophan, isoleucine, methyl succinic acid, S-adenosylmethionine (SAM), taurine, gamma-glutamylthreonine, arabitol/xylitol, erythronic acid, fumaric acid, stearoylcarnitine (C18), deoxycarnitine, cytidine 5′-diphosphocholine, 1-stearoyl-2-arachidonoyl-GPC (18:0/20:4), 1-stearoyl-2-arachidonoyl-GPI (18:0/20:4), glycerophosphoglycerol, N6-carbamoylthreonyladenosine, flavin adenine dinucleotide (FAD), 2-oxoarginine, lactic acid, gulonic acid, phenylalanine, 3-(4-hydroxyphenyl)lactic acid, 2-hydroxyglutaric acid, palmitoleoyl ethanolamide, 1-palmitoyl-2-stearoyl-GPC (16:0/18:0), 1-stearoyl-2-oleoyl-GPC (18:0/18:1), palmitoyl-oleoyl-glycerol (16:0/18:1), betaine, N-acetylneuraminic acid, malic acid, phosphoethanolamine, 1-myristoyl-2-arachidonoyl-GPC (14:0/20:4), beta-citrylglutamic acid, 1-methylhistidine, leucine, ethylmalonic acid, prolylglycine, stearoyl-arachidonoyl-glycerol (18:0/20:4), orotidine, 5-(galactosylhydroxy)-L-lysine, N-acetylglucosaminylasparagine, eicosenoylcarnitine (C20:1), cytidine-5′-diphosphoethanolamine, glycosyl-N-stearoyl-sphingosine (d18:1/18:0), palmitoyl dihydrosphingomyelin (d18:0/16:0), sphingosine, inosine, guanosine 5′-monophosphoric acid (5′-GMP), dimethylglycine, N-acetylalanine, aspartic acid, creatine, ribitol, 2-methylcitric acid/homocitric acid, arachidoylcarnitine (C20), S-methylglutathione, 1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6), stearoyl sphingomyelin (d18:1/18:0), nicotinamide, N-formylmethionine, UDP-N-acetylglucosamine/galactosamine, glucoronic acid, 1,2-dipalmitoyl-GPE (16:0/16:0), pseudouridine, alanine, glutamic acid, 1-myristoyl-2-palmitoyl-GPC (14:0/16:0), 1,2-dipalmitoyl-GPC (16:0/16:0), 1-palmitoyl-2-oleoyl-GPC (16:0/18:1), sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1), glycerophosphoethanolamine, 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1), UDP-glucuronic acid, and 1-methylnicotinamide, or a salt thereof, or a combination thereof; and/or one or more bacterial species found in a maternal microbiome; wherein the female subject is a fertile, ovulating female subject or a female subject seeking to implant an embryo. 
     Also disclosed herein are methods of inhibiting development of a disease or disorder in a fetus. 
     In certain embodiments, the present invention provides methods comprising administering to a maternal subject gestating the fetus, a composition comprising: a compound selected from trimethylamine-N-oxide (TMAO), N,N,N-trimethyl-5-aminovaleric acid (TMAV), imidazole propionic acid (IP), 3-indoxyl sulfuric acid (3-IS), hippuric acid (HIP), perfluorooctanesulfonic acid (PFOS), 3-sulfo-L-alanine, alpha-ketoglutaramic acid, 4-hydroxyglutamic acid, extoine, stachydrine, biotin, pyroglutamine, chiro-inositol, N1-methyl-2-pyridone-5-carboxamide, O-sulfo-L-tyrosine, 2′deoxyuridine, pyrraline, N-delta-acetylornithine, phenyl sulfuric acid, phenylacetylglycine, anserine, homostachydrine, serine, N1-methyl-4-pyridone-3-carboxamide, methyl glycopyranoside (alpha+beta), 3-carboxy-1-methylpyridin-1-ium, hypotaurine, 1,5-anhydroglucitol (1,5-AG), 1-oleoyl-2-linoleoyl-GPC (18:1/18:2), methionine, glutamine, malic acid, pantothenic acid, 5,6-dihydrouridine, ceramide (d18:1/17:0 d17:1/18.0) N6-methyllysine, allantoin, N2-acetyllysine, N-acetylglutamine, stearoylcarnitine (C18), arachidoylcarnitine (C20), arabitol, xylitol, 1-methylhistamine, xanthosine, xanthine, 1-ribosyl-imidazoleacetic acid, 5-methyl-2′-deoxycytidine, sphingomyelin (d18:0/20:0, d16:0/22:0), 1-methyl-4-imidazoleacetic acid, inosine 5′-monophosphoric acid (IMP), 1,2-distearoyl-GPC (18:0/18:0), 3-methylcytidine, pipecolate, N-stearoyl-sphingadienine (d18:2/18:0), homoserine, carnosine, 1-palmitoyl-GPI (16:0), 1-stearoyl-GPI (18:0), N6-succinyladenosine, 2′-deoxycytidine, stearoyl-docosahexaenoyl-glycerol (18:0/22:6), trigonelline (N′-methylnicotinate), hydroxyasparagine, gamma-glutamylglutamic acid, 2-palmitoylglycerol (16:0), ceramide (d18:1/17:0, d17:1/18:0), thiamin (Vitamin B1), N6-methyllysine, N6,N6-dimethyllysine, 3-hydroxy-3-methylglutaric acid, campesterol, allantoin, stachydrine, N2-acetyllysine, phenyllactic acid (PLA), gamma-glutamyltryptophan, N-palmitoyl-sphingosine (d18:1/16:0), O-sulfo-L-tyrosine, indolelactic acid, gamma-glutamylglutamine, N-acetylglucosamine 6-phosphoric acid, 1-oleoyl-GPS (18:1), 3-hydroxypalmitoylcarnitine, myo-inositol, behenoyl sphingomyelin (d18:1/22:0), maltotetraose, maltotriose, N-acetylglucosamine/N-acetylgalactosamine, N1-methyladenosine, uracil, 1-oleoyl-GPI (18:1), sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0), 3-ureidopropionic acid, 5-oxoproline, gamma-glutamyltyrosine, 1-(1-enyl-stearoyl)-GPE (P-18:0), cytidine 2′,3′-cyclic monophosphoric acid, 2′-deoxyguanosine 5′-monophosphoric acid (dGMP), thymidine, N6,N6,N6-trimethyllysine, 1-palmitoyl-GPC (16:0), 1-(1-enyl-palmitoyl)-GPE (P-16:0), N-stearoyl-sphinganine (d18:0/18:0), N-arachidoyl-sphingosine (d18:1/20:0), 3′-dephosphocoenzyme A, 5-hydroxylysine, arabonic acid/xylonic acid, 1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6), glutamine, 1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0), N-behenoyl-sphingadienine (d18:2/22:0), xylulose 5-phosphoric acid, 1-oleoyl-GPC (18:1), 1-stearoyl-GPE (18:0), glycerol 3-phosphoric acid, N-stearoyl-sphingosine (d18:1/18:0), 7-methylguanine, N2,N2-dimethylguanosine, N-acetylglutamine, methionine, pro-hydroxy-pro, dihydroxyacetone phosphoric acid (DHAP), 1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6), sphingomyelin (d18:1/20:0, d16:1/22:0), uric acid, adenylosuccinic acid, cystathionine, spermine, mannitol/sorbitol, 2-hydroxyadipic acid, N-palmitoyl-sphinganine (d18:0/16:0), sphingomyelin (d18:0/18:0, d19:0/17:0), sphingomyelin (d18:1/24:1, d18:2/24:0), alpha-hydroxyisovaleric acid, citrulline, ribulonic acid/xylulonic acid, succinylcarnitine (C4-DC), ceramide (d16:1/24:1, d18:1/22:1), hypoxanthine, 5,6-dihydrouridine, gamma-aminobutyric acid (GABA), oleoyl ethanolamide, choline, 1-palmitoyl-GPE (16:0), palmitoyl-linoleoyl-glycerol (16:0/18:2), ceramide (d18:2/24:1, d18:1/24:2), cholesterol, 2′-O-methylcytidine, nicotinamide riboside, pantothenic acid, pyridoxal, N-acetylaspartic acid (NAA), C-glycosyltryptophan, methionine sulfoxide, spermidine, 1-palmitoyl-2-oleoyl-GPG (16:0/18:1), lignoceroyl sphingomyelin (d18:1/24:0), desmosterol, N1-methylinosine, cytidine, N-acetyl-aspartyl-glutamic acid (NAAG), sedoheptulose, galactonic acid, cytidine 5′-monophospho-N-acetylneuraminic acid, glycerophosphoinositol, uridine, salicylic acid, N-acetylglutamic acid, gamma-glutamyl-epsilon-lysine, glycerophosphoserine, 1-stearoyl-2-oleoyl-GPE (18:0/18:1), beta-alanine, 5-methylcytidine, methylphosphoric acid, imidazole lactic acid, sedoheptulose-7-phosphoric acid, 1-palmitoyl-2-stearoyl-GPE (16:0/18:0), guanosine 5′-diphosphoric acid (GDP), 3-ureidoisobutyric acid, tryptophan, isoleucine, methyl succinic acid, S-adenosylmethionine (SAM), taurine, gamma-glutamylthreonine, arabitol/xylitol, erythronic acid, fumaric acid, stearoylcarnitine (C18), deoxycarnitine, cytidine 5′-diphosphocholine, 1-stearoyl-2-arachidonoyl-GPC (18:0/20:4), 1-stearoyl-2-arachidonoyl-GPI (18:0/20:4), glycerophosphoglycerol, N6-carbamoylthreonyladenosine, flavin adenine dinucleotide (FAD), 2-oxoarginine, lactic acid, gulonic acid, phenylalanine, 3-(4-hydroxyphenyl)lactic acid, 2-hydroxyglutaric acid, palmitoleoyl ethanolamide, 1-palmitoyl-2-stearoyl-GPC (16:0/18:0), 1-stearoyl-2-oleoyl-GPC (18:0/18:1), palmitoyl-oleoyl-glycerol (16:0/18:1), betaine, N-acetylneuraminic acid, malic acid, phosphoethanolamine, 1-myristoyl-2-arachidonoyl-GPC (14:0/20:4), beta-citrylglutamic acid, 1-methylhistidine, leucine, ethylmalonic acid, prolylglycine, stearoyl-arachidonoyl-glycerol (18:0/20:4), orotidine, 5-(galactosylhydroxy)-L-lysine, N-acetylglucosaminylasparagine, eicosenoylcarnitine (C20:1), cytidine-5′-diphosphoethanolamine, glycosyl-N-stearoyl-sphingosine (d18:1/18:0), palmitoyl dihydrosphingomyelin (d18:0/16:0), sphingosine, inosine, guanosine 5′-monophosphoric acid (5′-GMP), dimethylglycine, N-acetylalanine, aspartic acid, creatine, ribitol, 2-methylcitric acid/homocitric acid, arachidoylcarnitine (C20), S-methylglutathione, 1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6), stearoyl sphingomyelin (d18:1/18:0), nicotinamide, N-formylmethionine, UDP-N-acetylglucosamine/galactosamine, glucoronic acid, 1,2-dipalmitoyl-GPE (16:0/16:0), pseudouridine, alanine, glutamic acid, 1-myristoyl-2-palmitoyl-GPC (14:0/16:0), 1,2-dipalmitoyl-GPC (16:0/16:0), 1-palmitoyl-2-oleoyl-GPC (16:0/18:1), sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1), glycerophosphoethanolamine, 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1), UDP-glucuronic acid, and 1-methylnicotinamide, or a salt thereof, or a combination thereof; and/or one or more bacterial species found in a maternal microbiome. 
     In certain embodiments, the present invention provides methods comprising administering to a female subject a composition comprising: a compound selected from trimethylamine-N-oxide (TMAO), N,N,N-trimethyl-5-aminovaleric acid (TMAV), imidazole propionic acid (IP), 3-indoxyl sulfuric acid (3-IS), hippuric acid (HIP), perfluorooctanesulfonic acid (PFOS), 3-sulfo-L-alanine, alpha-ketoglutaramic acid, 4-hydroxyglutamic acid, extoine, stachydrine, biotin, pyroglutamine, chiro-inositol, N1-methyl-2-pyridone-5-carboxamide, O-sulfo-L-tyrosine, 2′deoxyuridine, pyrraline, N-delta-acetylornithine, phenyl sulfuric acid, phenylacetylglycine, anserine, homostachydrine, serine, N1-methyl-4-pyridone-3-carboxamide, methyl glycopyranoside (alpha+beta), 3-carboxy-1-methylpyridin-1-ium, hypotaurine, 1,5-anhydroglucitol (1,5-AG), 1-oleoyl-2-linoleoyl-GPC (18:1/18:2), methionine, glutamine, malic acid, pantothenic acid, 5,6-dihydrouridine, ceramide (d18:1/17:0 d17:1/18.0) N6-methyllysine, allantoin, N2-acetyllysine, N-acetylglutamine, stearoylcarnitine (C18), arachidoylcarnitine (C20), arabitol, xylitol, 1-methylhistamine, xanthosine, xanthine, 1-ribosyl-imidazoleacetic acid, 5-methyl-2′-deoxycytidine, sphingomyelin (d18:0/20:0, d16:0/22:0), 1-methyl-4-imidazoleacetic acid, inosine 5′-monophosphoric acid (IMP), 1,2-distearoyl-GPC (18:0/18:0), 3-methylcytidine, pipecolate, N-stearoyl-sphingadienine (d18:2/18:0), homoserine, carnosine, 1-palmitoyl-GPI (16:0), 1-stearoyl-GPI (18:0), N6-succinyladenosine, 2′-deoxycytidine, stearoyl-docosahexaenoyl-glycerol (18:0/22:6), trigonelline (N′-methylnicotinate), hydroxyasparagine, gamma-glutamylglutamic acid, 2-palmitoylglycerol (16:0), ceramide (d18:1/17:0, d17:1/18:0), thiamin (Vitamin B1), N6-methyllysine, N6,N6-dimethyllysine, 3-hydroxy-3-methylglutaric acid, campesterol, allantoin, stachydrine, N2-acetyllysine, phenyllactic acid (PLA), gamma-glutamyltryptophan, N-palmitoyl-sphingosine (d18:1/16:0), O-sulfo-L-tyrosine, indolelactic acid, gamma-glutamylglutamine, N-acetylglucosamine 6-phosphoric acid, 1-oleoyl-GPS (18:1), 3-hydroxypalmitoylcarnitine, myo-inositol, behenoyl sphingomyelin (d18:1/22:0), maltotetraose, maltotriose, N-acetylglucosamine/N-acetylgalactosamine, N1-methyladenosine, uracil, 1-oleoyl-GPI (18:1), sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0), 3-ureidopropionic acid, 5-oxoproline, gamma-glutamyltyrosine, 1-(1-enyl-stearoyl)-GPE (P-18:0), cytidine 2′,3′-cyclic monophosphoric acid, 2′-deoxyguanosine 5′-monophosphoric acid (dGMP), thymidine, N6,N6,N6-trimethyllysine, 1-palmitoyl-GPC (16:0), 1-(1-enyl-palmitoyl)-GPE (P-16:0), N-stearoyl-sphinganine (d18:0/18:0), N-arachidoyl-sphingosine (d18:1/20:0), 3′-dephosphocoenzyme A, 5-hydroxylysine, arabonic acid/xylonic acid, 1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6), glutamine, 1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0), N-behenoyl-sphingadienine (d18:2/22:0), xylulose 5-phosphoric acid, 1-oleoyl-GPC (18:1), 1-stearoyl-GPE (18:0), glycerol 3-phosphoric acid, N-stearoyl-sphingosine (d18:1/18:0), 7-methylguanine, N2,N2-dimethylguanosine, N-acetylglutamine, methionine, pro-hydroxy-pro, dihydroxyacetone phosphoric acid (DHAP), 1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6), sphingomyelin (d18:1/20:0, d16:1/22:0), uric acid, adenylosuccinic acid, cystathionine, spermine, mannitol/sorbitol, 2-hydroxyadipic acid, N-palmitoyl-sphinganine (d18:0/16:0), sphingomyelin (d18:0/18:0, d19:0/17:0), sphingomyelin (d18:1/24:1, d18:2/24:0), alpha-hydroxyisovaleric acid, citrulline, ribulonic acid/xylulonic acid, succinylcarnitine (C4-DC), ceramide (d16:1/24:1, d18:1/22:1), hypoxanthine, 5,6-dihydrouridine, gamma-aminobutyric acid (GABA), oleoyl ethanolamide, choline, 1-palmitoyl-GPE (16:0), palmitoyl-linoleoyl-glycerol (16:0/18:2), ceramide (d18:2/24:1, d18:1/24:2), cholesterol, 2′-O-methylcytidine, nicotinamide riboside, pantothenic acid, pyridoxal, N-acetylaspartic acid (NAA), C-glycosyltryptophan, methionine sulfoxide, spermidine, 1-palmitoyl-2-oleoyl-GPG (16:0/18:1), lignoceroyl sphingomyelin (d18:1/24:0), desmosterol, N1-methylinosine, cytidine, N-acetyl-aspartyl-glutamic acid (NAAG), sedoheptulose, galactonic acid, cytidine 5′-monophospho-N-acetylneuraminic acid, glycerophosphoinositol, uridine, salicylic acid, N-acetylglutamic acid, gamma-glutamyl-epsilon-lysine, glycerophosphoserine, 1-stearoyl-2-oleoyl-GPE (18:0/18:1), beta-alanine, 5-methylcytidine, methylphosphoric acid, imidazole lactic acid, sedoheptulose-7-phosphoric acid, 1-palmitoyl-2-stearoyl-GPE (16:0/18:0), guanosine 5′-diphosphoric acid (GDP), 3-ureidoisobutyric acid, tryptophan, isoleucine, methyl succinic acid, S-adenosylmethionine (SAM), taurine, gamma-glutamylthreonine, arabitol/xylitol, erythronic acid, fumaric acid, stearoylcarnitine (C18), deoxycarnitine, cytidine 5′-diphosphocholine, 1-stearoyl-2-arachidonoyl-GPC (18:0/20:4), 1-stearoyl-2-arachidonoyl-GPI (18:0/20:4), glycerophosphoglycerol, N6-carbamoylthreonyladenosine, flavin adenine dinucleotide (FAD), 2-oxoarginine, lactic acid, gulonic acid, phenylalanine, 3-(4-hydroxyphenyl)lactic acid, 2-hydroxyglutaric acid, palmitoleoyl ethanolamide, 1-palmitoyl-2-stearoyl-GPC (16:0/18:0), 1-stearoyl-2-oleoyl-GPC (18:0/18:1), palmitoyl-oleoyl-glycerol (16:0/18:1), betaine, N-acetylneuraminic acid, malic acid, phosphoethanolamine, 1-myristoyl-2-arachidonoyl-GPC (14:0/20:4), beta-citrylglutamic acid, 1-methylhistidine, leucine, ethylmalonic acid, prolylglycine, stearoyl-arachidonoyl-glycerol (18:0/20:4), orotidine, 5-(galactosylhydroxy)-L-lysine, N-acetylglucosaminylasparagine, eicosenoylcarnitine (C20:1), cytidine-5′-diphosphoethanolamine, glycosyl-N-stearoyl-sphingosine (d18:1/18:0), palmitoyl dihydrosphingomyelin (d18:0/16:0), sphingosine, inosine, guanosine 5′-monophosphoric acid (5′-GMP), dimethylglycine, N-acetylalanine, aspartic acid, creatine, ribitol, 2-methylcitric acid/homocitric acid, arachidoylcarnitine (C20), S-methylglutathione, 1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6), stearoyl sphingomyelin (d18:1/18:0), nicotinamide, N-formylmethionine, UDP-N-acetylglucosamine/galactosamine, glucoronic acid, 1,2-dipalmitoyl-GPE (16:0/16:0), pseudouridine, alanine, glutamic acid, 1-myristoyl-2-palmitoyl-GPC (14:0/16:0), 1,2-dipalmitoyl-GPC (16:0/16:0), 1-palmitoyl-2-oleoyl-GPC (16:0/18:1), sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1), glycerophosphoethanolamine, 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1), UDP-glucuronic acid, and 1-methylnicotinamide, or a salt thereof, or a combination thereof; and/or one or more bacterial species found in a maternal microbiome; wherein the female subject is a fertile, ovulating female subject or a female subject seeking to implant an embryo. 
     Such pharmaceutical preparations may be for use in treating or preventing a condition or disease as described herein. 
    
    
     
       BRIEF DESCRIPTION OF THE FIGURES 
         FIGS. 1A-1M : Depletion of the maternal microbiota during early gestation alters fetal brain gene expression and impairs fetal thalamocortical axonogenesis.  1 A, Heatmap of differentially expressed genes in embryonic brains of E14.5 offspring from conventionally colonized (specific pathogen-free, SPF) and antibiotic-treated (ABX) dams (Wald Test, p&lt;0.05, n=offspring from 3 dams).  1 B, Representative immunofluorescence images of Netrin-G1a (magenta in the original image) and L1 (cyan in the original image) staining in embryonic brain sections (rostra′ to caudal) from E14.5 offspring of SPF, ABX and germ-free (GF) dams. Scale bar=500 μm.  1 C, Average Netrin-G1a fluorescence intensity per matched area of region of interest (ROI) (“yellow-in-the-original-image” dotted lines) across 800 μm of rostral to caudal embryonic brain sections of E14.5 offspring from SPF, ABX, and GF dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF, 7 ABX, 4 GF dams).  1 D, Average L1 fluorescence normalized to control SPF ROI (“yellow-in-the-original-image” dotted lines) area across 800 μm of rostral to caudal embryonic brain sections of E14.5 offspring from SPF, ABX, and GF dams (Two-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF, 7 ABX, 4 GF dams).  1 E, Representative 3-D rendering of Netrin-G1a staining (purple in the original image) in cleared whole embryonic brains of E14.5 offspring from SPF, ABX, and GF dams. Th=thalamus. Scale bar=100 μm.  1 F, Volume of Netrin-G1a axons from cleared whole embryonic brains of E14.5 offspring of SPF, ABX, and GF dams. (Two-way ANOVA with Tukey&#39;s (SPF vs ABX); Mann-Whitney test (SPF vs GF), n=offspring from 5 dams per group).  1 G, Length of Netrin-G1a axons in cleared whole embryonic brains from E14.5 offspring of SPF, ABX, and GF dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 5 dams per group).  1 H, Distance from rostral tip of Netrin-G1a staining to the cortex in cleared whole embryonic brains from E14.5 offspring of SPF, ABX, and GF dams. (Two-way ANOVA with Tukey&#39;s (SPF vs ABX); Mann-Whitney test (SPF vs GF), n=offspring from 5 dams per group).  1 I, Average circumference of the Netrin-G1 a axonal bundle at the internal capsule (IC) in whole embryonic brains from E14.5 offspring of SPF, ABX, and GF dams. (Two-way ANOVA with Tukey&#39;s (SPF vs ABX); Mann-Whitney test (SPF vs GF), n=offspring from 5 dams per group).  1 J, Schematic of E14.5 thalamic (Th), striatal (St) and hypothalamic (Hy) explant co-culture for axon outgrowth assay. The bar (gray colored in the original image; to the left of Th) indicates site of Th axon quantification, proximal to St.  1 K, Representative TUJ1 fluorescence images of axon outgrowth from i) SPF Th explant proximal to SPF St explant (top left), ii) ABX Th explant proximal to ABX St (top right), iii) SPF Th explant proximal to ABX St explant (bottom left), iv) ABX Th explant proximal to SPF St explant (bottom right). Scale bar=250 μm.  1 L, Number of axons per 200 μm of Th perimeter proximal to St explant, normalized to measurements from Th monoculture. (Two-way ANOVA with Tukey&#39;s, n=offspring from 14 SPF+SPF, 20 ABX+ABX, 10 SPF+ABX, 10 ABX+SPF dams).  1 M, Length of Th axons proximal to St explant, normalized to measurements from Th monoculture. (Two-way ANOVA with Tukey&#39;s, n=offspring from 14 SPF+SPF, 20 ABX+ABX, 10 SPF+ABX, 10 ABX+SPF dams). Data are presented as mean±SEM, *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001, n.s.=not statistically significant. 
         FIGS. 2A-2D : Network analysis and qPCR validation of fetal brain RNAseq data.  2 A, DAVID gene ontology analysis of differentially expressed genes from whole embryonic brains from E14.5 offspring of SPF compared to those from ABX dams (Fisher exact, q&lt;0.05, n=offspring from 3 dams per group).  2 B, Quantitative RT-PCR for NTNG1 and LRRC4C expression in whole embryonic brains from E14.5 offspring of SPF, ABX or GF dams (Two-way ANOVA with Tukey&#39;s, n=offspring from 9 SPF, 15 ABX, 10 Sp dams).  2 C, STRING protein interaction network of genes downregulated in whole embryonic brains from E14.5 offspring of ABX dams compared to those from SPF dams (q&lt;0.05, n=offspring from 3 dams).  2 D, STRING protein interaction networks of genes upregulated in whole embryonic brains from E14.5 offspring of ABX dams compared to those from SPF dams (q&lt;0.05, n=offspring from 3 dams). Data are presented as mean±SEM. *p&lt;0.05, n.s.=not statistically significant. 
         FIGS. 3A-3I : Netrin-G1a thalamocortical axons in embryonic brains of E14.5 offspring from gnotobiotic dams.  3 A, Reference diagrams of E14.5 coronal embryonic brain sections.  3 B, Immunofluorescence images of Netrin-G1a in four independent embryonic brain sections from E14.5 offspring of SPF dams. 200 μm intervals. Scale bar: 500 μm.  3 C, Immunofluorescence image of Netrin-G1a in four independent embryonic brain sections from E14.5 offspring of ABX dams. 200 μm intervals. Scale bar: 500 μm.  3 D, Immunofluorescence image of Netrin-G1a in four independent embryonic brain sections from E14.5 offspring of GF dams. 200 μm intervals. Scale bar: 500 μm.  3 E, Immunofluorescence image of Netrin-G1a in four independent embryonic brain sections from E14.5 offspring of dams colonized with Sp bacteria. 200 μm intervals. Scale bar: 500 μm.  3 F, Average Netrin-G1 a fluorescence intensity per matched area of region of interest (ROI) (“yellow-in-the-original-image” dotted lines) in 800 μm of rostral to caudal embryonic brain sections of E14.5 offspring from SPF, ABX, GF and Sp-colonized dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF, 7 ABX, 4 GF, 5 Sp dams).  3 G, Total Netrin-G1a fluorescence intensity across 800 μm of rostral to caudal sections of E14.5 embryonic brains from SPF, ABX, GF, and Sp-colonized dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF, 7 ABX, 4 GF, 5 Sp dams).  3 H, Average area of Netrin-G1a-positive staining across 800 μm of rostral to caudal embryonic brain sections of E14.5 offspring from SPF, ABX, GF and Sp-colonized dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF, 7 ABX, 4 GF, 5 Sp dams).  3 I, Average DAPI fluorescence intensity normalized to per matched ROI (“yellow-in-the-original-image” dotted lines) in 800 μm of rostral to caudal embryonic brain sections of E14.5 offspring from SPF, ABX, GF and Sp-colonized dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF, 7 ABX, 4 GF, 5 Sp dams). Data are presented as mean±SEM. *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001, n.s.=not statistically significant. 
         FIGS. 4A-4E : L1 thalamocortical axons in embryonic brains of E14.5 offspring from gnotobiotic dams.  4 A and  4 B, Representative immunofluorescence images of Netrin-G1a (magenta in the original image) and L1 (cyan in the original image) in rostral to caudal embryonic brain sections from E14.5 offspring of SPF, ABX, GF and Sp-colonized dams. Scale bar=500 μm.  4 C, Average L1 fluorescence intensity normalized to matched area of region of interest (“yellow-in-the-original-image” dotted lines) across 800 μm of rostral to caudal sections from embryonic brain sections of E14.5 offspring from SPF, ABX, GF and Sp-colonized dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF, 7 ABX, 4 GF, 5 Sp dams).  4 D, Average area of L1-positive staining across 800 μm of rostral to caudal sections from embryonic brain sections of E14.5 offspring from SPF, ABX, GF and Sp-colonized dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 4 SPF, 5 ABX, 3 GF, 5 Sp dams).  4 E, L1 mean fluorescence intensity per L1-positive area across 800 μm of rostral to caudal sections from embryonic brain sections of E14.5 offspring from SPF, ABX, GF and Sp-colonized dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 4 SPF, 4 ABX, 4 GF, 4 Sp dams). Data are presented as mean±SEM, *p&lt;0.05, **p&lt;0.01, ****p&lt;0.0001, n. s.=not statistically significant. 
         FIGS. 5A-5L : Number and length of axons from thalamic explant monocultures and co-cultures with striatal and hypothalamic explants.  5 A, Diagram of E14.5 thalamic (Th) explant monoculture for the axon outgrowth assay. Representative immunofluorescence image of axon outgrowth from 48-hour monoculture of thalamic explants from E14.5 offspring of SPF, ABX and Sp-colonized dams. Scale bar=250 μm.  5 B, Number of axons in monoculture of Th explants from E14.5 offspring of SPF, ABX and Sp-colonized dams (One-way ANOVA with Tukey&#39;s, n=offspring from 26 SPF, 20 ABX, 10 Sp dams).  5 C, Length of axons in SPF, ABX, and Sp Th explant monoculture (One-way ANOVA with Tukey&#39;s, n=offspring from 20 dams).  5 D, Schematic of E14.5 Th, striatal (St) and hypothalamic (Hy) explant co-culture in axon outgrowth assay. The bar (gray colored in the original image; to the right of Th) indicates site of Th axon quantification, proximal to Hy. Representative fluorescence images of axon outgrowth from i) SPF Th explant proximal to SPF Hy explant (top left), ii) ABX Th explant proximal to ABX Hy explant (top right), iii) SPF Th explant proximal to ABX Hy explant (bottom left), iv) ABX Th explant proximal to SPF Hy explant (bottom right). Scale bar=250 μm.  5 E, Number of axons per 200 μm of Th perimeter proximal to Hy explant, normalized to measurements from corresponding Th monoculture. (One-way ANOVA with Tukey&#39;s, n=offspring from 14 SPF+SPF, 20 ABX+ABX, 9 SPF+ABX, 10 ABX+SPF dams).  5 F, Length of Th axons proximal to Hy explant, normalized to measurements from corresponding Th monoculture. (One-way ANOVA with Tukey&#39;s, n=offspring from 14 SPF+SPF, 18 ABX+ABX, 9 SPF+ABX, 10 ABX+SPF dams).  5 G, Schematic of E14.5 Th, St and Hy explant co-culture for axon outgrowth assay. The bar (gray colored in the original image; to the left of Th) indicates site of Th axon quantification, proximal to St. Representative fluorescence images of axon outgrowth from a i) SPF Th explant proximal to SPF St explant (top left), ii) ABX Th explant proximal to ABX St explant (top right), iii) Sp Th explant proximal to Sp St explant (bottom left), iv) Sp Th explant proximal to ABX St explant (bottom right). Scale bar=250 μm.  5 H, Number of axons per 200 μm of Th perimeter proximal to St explant, normalized to a measurement from corresponding Th monoculture. (One-way ANOVA with Tukey&#39;s, n=offspring from 14 SPF+SPF, 20 ABX+ABX, 14 Sp+Sp, 6 Sp+ABX dams).  5 I, Length of Th axons proximal to ST explant, normalized to measurements from corresponding Th monoculture. (One-way ANOVA with Tukey&#39;s, n=offspring from 14 SPF+SPF, 18 ABX+ABX, 14 Sp+Sp, 6 Sp+ABX dams).  5 J, Schematic of E14.5 Th, St and Hy explant co-culture in axon outgrowth assay. The bar (gray colored in the original image; to the right of Th) indicates site of Th axon quantification, proximal to Hy. Representative fluorescence images of axon outgrowth from a i) SPF Th explant proximal to an SPF Hy explant (top left), ii) ABX Th explant proximal to an ABX Hy explant (top right), iii) Sp Th explant proximal to a Sp Hy explant (bottom left), iv) Sp Th explant proximal to an ABX Hy explant (bottom right). Scale bar=250 μm. Red (in the original image) arrows highlight sparse short axons.  5 K, Number of axons per 200 μm of Th perimeter proximal to Hy explant, normalized to a measurement from Th corresponding monoculture. (One-way ANOVA with Tukey&#39;s, n=offspring from 14 SPF+SPF, 18 ABX+ABX, 14 Sp+Sp, 6 Sp+ABX dams).  5 L, Length of Th axons proximal to Hy explant, normalized to measurements from corresponding Th monoculture. (One-way ANOVA with Tukey&#39;s, n=offspring from 14 SPF+SPF, 18 ABX+ABX, 14 Sp+Sp, 6 Sp+ABX dams). Data are presented as mean±SEM. *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001, n. s.=not statistically significant. 
         FIGS. 6A-6G : Depletion of the maternal microbiota during early gestation yields adult offspring with deficient tactile sensory behavior.  6 A, Experimental timeline of vehicle or ABX treatment at 1 week prior to timed mating, conventionalization with SPF bedding on E14.5, and offspring behavioral testing at 6-8 weeks.  6 B, The von Frey filament test applies filaments with increasing force (0.4, 0.6, 1, 1.4, 2, 4 grams) to the hindpaw to identify the threshold mechanical force needed to elicit a sensorimotor response.  6 C, Force filament required to induce 50% paw withdrawal in adult offspring of SPF and ABX dams (One-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF and 7 ABX dams).  6 D, Adhesive removal test for sensorimotor behavioral measures sensitivity to detect and dexterity to remove an adhesive tape placed on the mouse forepaw.  6 E, Forepaw sensitivity, as measured as the latency to contact the adhesive tape, in adult offspring of SPF and ABX dams (One-way ANOVA with Tukey&#39;s, n=offspring from 6 dams per group).  6 F, Forepaw motor dexterity, as measured as the latency to remove the adhesive tape after first contact, in adult offspring of SPF and ABX dams (One-way ANOVA with Tukey&#39;s, n=offspring from 6 dams per group).  6 G, Data for latency to contact and latency to remove the forepaw adhesive in individual mice. (Two-way ANOVA with Sidak&#39;s, n=offspring from 6 dams per group). Data are presented as mean±SEM. Data shown for SPF and ABX are as displayed in  FIGS. 10A-10M, 12A-12I, 14A-14I, 7A-7F, and 17A-17F . Statistics reflect analysis together with experimental groups: Sp. **p&lt;0.01, ***p&lt;0.001. 
         FIGS. 7A-7F : Absence of sex differences in behavioral performance of offspring from gnotobiotic dams.  7 A, Force filament required to induce 50% paw withdrawal in adult offspring of SPF, ABX, and Sp dams (One-way ANOVA with Tukey&#39;s, n=10 SPF, 23 ABX, 25 Sp offspring).  7 B, Latency to contact the adhesive tape, in adult offspring of SPF, ABX, Sp dams (One-way ANOVA with Tukey&#39;s, n=25 SPF, 19 ABX, 39 Sp offspring).  7 C, Latency to remove the adhesive tape after first contact in adult offspring of SPF, ABX, and Sp dams (One-way ANOVA with Tukey&#39;s, n=25 SPF, 19 ABX, 39 Sp offspring).  7 D, Force filament required to induce 50% paw withdrawal in male and female adult offspring of SPF, ABX, and Sp dams. Male and female comparisons per litter (left) or individual offspring (right) (Two-way ANOVA with Tukey&#39;s, n=10 male, 10 female SPF; 7 male, 16 female ABX; 13 male, 12 female Sp offspring).  7 E, Latency to contact the adhesive tape in male and female adult offspring of SPF, ABX, Sp dams. Male and female comparisons per litter (left) or individual offspring (right) (Two-way ANOVA with Tukey&#39;s, 15 male, 10 female SPF; 4 male, 15 female ABX; 21 male, 18 female Sp offspring).  7 F, Latency to remove the adhesive tape after first contact in male and female adult offspring of SPF, ABX, and Sp dams. Male and female comparisons per litter (left) or individual offspring (right) (Two-way ANOVA with Tukey&#39;s, n=15 male, 10 female SPF; 4 male, 15 female ABX; 20 male, 18 female Sp offspring). Data are presented as mean±SEM. *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, n.s=not statistically significant. 
         FIGS. 8A-8F : Thermal, visual, motor and acoustic sensory behaviors in adult offspring of gnotobiotic dams.  8 A, Latency to withdraw in response to a hot plate in adult offspring of SPF, ABX, and Sp-colonized dams (One-way ANOVA with Tukey&#39;s; n=9 SPF, 19 ABX, 25 Sp offspring).  8 B, Visual depth discrimination determined by a response towards the “safe” or “cliff” zone in the visual cliff test in adult offspring of SPF, ABX, and Sp-colonized dams (One-way ANOVA with Tukey&#39;s; n=9 SPF, 19 ABX, 25 Sp offspring).  8 C, Percentage of time spent investigating novel texture in whisker texture test in adult offspring of SPF, ABX, and Sp-colonized dams (One-way ANOVA with Tukey&#39;s; n=5 SPF, 15 ABX, 18 Sp offspring).  8 D, Time spent on the rotarod in adult offspring of SPF, ABX, and Sp-colonized dams (One-way ANOVA with Tukey&#39;s; n=45 SPF, 20 ABX, 55 Sp offspring).  8 E, Habituation in response to three trials of 120 db acoustic tone in adult offspring of SPF, ABX, and Sp-colonized mice (Two-way ANOVA with Tukey&#39;s; n=45 SPF, 15 ABX, 54 Sp offspring).  8 F, Inhibitory effect of 70, 75, and 80 db prepulse on startle response to a 120 db acoustic tone in adult offspring of SPF, ABX, and Sp-colonized mice (Two-way ANOVA with Tukey&#39;s; n=45 SPF, 15 ABX, 54 Sp offspring). Data are presented as mean±SEM. *p&lt;0.05, **p&lt;0.01, n. s=not statistically significant. 
         FIGS. 9A-9F : Fetal brain gene expression in offspring of dams colonized with a consortium of spore-forming bacteria (Sp).  9 A, Principal coordinate analysis of 16S rDNA sequencing data of feces from SPF compared to Sp-colonized dams at E14.5 (n=4 dams per group)  9 B, Taxonomic diversity of the fecal microbiota of SPF and Sp-colonized dams (n=4 dams per group).  9 C, Heatmap of genes that were similarly differentially expressed in embryonic brains from E14.5 offspring of SPF and SP dams compared to ABX dams (p&lt;0.05; Wald test, n=offspring from 3 dams per group). Data shown for SPF and ABX are as displayed in  FIGS. 1A-1M . Red font (in the original image) indicates axonogenesis-related genes tested by qRT-PCR.  9 D, qRT-PCR for PRR12 expression in embryonic brains from E14.5 offspring of SPF, ABX, and Sp-colonized dams (One-way ANOVA with Tukey&#39;s; n=offspring from 11 SPF, 15 ABX, 8 Sp dams).  9 E, qRT-PCR for NRCAM, NRP2, PLXNA3, and SEMA3F expression in embryonic brains from E14.5 offspring of SPF, ABX, and Sp-colonized dams (Two-way ANOVA with Tukey&#39;s; n=offspring from 10 SPF, 10 ABX, 8 Sp dams).  9 F, qRT-PCR for expression of axonogenesis-related genes NTN1, SLIT1, DCC, UNC5A, UNC5B, UNC5C, ROBO1, ROBO2 in embryonic brains from E14.5 offspring of SPF, ABX, and Sp-colonized dams (Two-way ANOVA with Tukey&#39;s; n=offspring from 11 SPF, 16 ABX, 8 Sp dams). Data are presented as mean±SEM. *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001, n. s.=not statistically significant. 
         FIGS. 10A-10M : Gnotobiotic colonization of the maternal microbiota during early gestation prevents neurodevelopmental and behavioral abnormalities induced by maternal microbiota depletion.  10 A, Heatmap of differentially expressed genes (p&lt;0.05) in embryonic brains from E14.5 offspring of SPF, ABX, and Sp-colonized dams (Wald test, n=offspring from 3 dams).  10 B, Expression of NTNG1 and LRRC4C as measured by quantitative RT-PCR in embryonic brains of E14.5 offspring from SPF, ABX, and Sp-colonized dams (Two-way ANOVA with Tukey&#39;s, n=offspring from 9 SPF, 15 ABX, 8 Sp dams).  10 C, Representative immunofluorescence images of Netrin-G1a (magenta in the original image) and L1 (cyan in the original image) staining in embryonic brain sections (rostral to caudal) from E14.5 offspring from different dams. Scale bar=500 μm.  10 D, Average Netrin-G1a fluorescence intensity per matched area of region of interest (ROI) (“yellow-in-the-original-image” dotted lines) across 800 μm of rostral to caudal embryonic brain sections of E14.5 offspring from SPF, ABX, and Sp-colonized dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF, 7 ABX, 5 Sp dams).  10 E, Average L1 fluorescence intensity of L1 per matched area of ROI (“yellow-in-the-original-image” dotted lines) across 800 μm of rostral to caudal embryonic brain sections of E14.5 offspring from SPF, ABX, and Sp-colonized dams (Two-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF, 7 ABX, 5 Sp dams).  10 F, Representative 3-D rendering of Netrin-G1a staining (green in the original image) in cleared whole embryonic brains from E14.5 offspring of Sp dams. Scale bar=100 μm.  10 G, Volume of Netrin-G1a axons in cleared whole embryonic brains from E14.5 offspring of SPF, ABX, and Sp-colonized dams. (One-way ANOVA with Tukey&#39;s; n=offspring from 5 dams per group).  10 H, Length of Netrin-G1a axons in cleared whole embryonic brains from E14.5 offspring of SPF, ABX, and GF dams. (One-way ANOVA with Tukey&#39;s; n=offspring from 5 dams per group).  10 I, Distance from distal tip of Netrin-G1a staining to the cortex in whole embryonic brains from E14.5 offspring of SPF, ABX, and Sp-colonized dams. (One-way ANOVA with Tukey&#39;s; n=offspring from 5 dams per group).  10 J, Average circumference of the Netrin-G1a axonal bundle at the internal capsule (IC) in whole embryonic brains from E14.5 offspring of SPF, ABX, and Sp-colonized dams. (One-way ANOVA with Tukey&#39;s; n=offspring from 5 dams per group).  10 K, Experimental timeline of ABX treatment and Sp colonization prior to breeding, conventionalization with SPF microbiota on E14.5, and offspring behavioral testing at 6-8 weeks.  10 L, Force filament required to induce 50% paw withdrawal in adult offspring of SPF, ABX and Sp-colonized dams (One-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF, 7 ABX, 7 Sp dams).  10 M, left: Forepaw sensitivity, as measured as the latency to contact the adhesive tape, in adult offspring of SPF, ABX and Sp-colonized dams (One-way ANOVA with Tukey&#39;s, n=offspring from 6 SPF, 6 ABX, 7 Sp dams). right: Forepaw motor dexterity, as measured as the latency to remove the adhesive tape after first contact, in adult offspring of SPF, ABX and Sp-colonized dams (One-way ANOVA with Tukey&#39;s, n=offspring from 6 SPF, 6 ABX, 7 Sp dams). Data are presented as mean±SEM. Data shown for SPF and ABX are as displayed in  FIGS. 1A-1M, 6A-6G, 14A-14I, 3A-3I, 4A-4D, 5A-5L, and 7A-7F . *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001, n. s.=not statistically significant. 
         FIGS. 11A-11D : Fetal Netrin-G1a thalamocortical axons offspring of dams colonized with a consortium of  Bacteroides  species (BD).  11 A, Taxonomic diversity of the fecal microbiota of SPF and BD colonized dams (n=6 dams).  11 B, Representative immunofluorescence images of Netrin-G1a (magenta in the original image) and L1 (cyan in the original image) staining in embryonic brain sections (rostra′ to caudal) from E14.5 offspring of BD-colonized dams. Scale bar=500 μm.  11 C, Average Netrin-G1a fluorescence intensity per matched area of region of interest (ROI) (“yellow-in-the-original-image” dotted lines) across 800 μm of rostral to caudal embryonic brain sections of E14.5 offspring from SPF, ABX, and BD-colonized dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF, 7 ABX, 4 BD dams).  11 D, Average L1 fluorescence intensity per matched area of ROI (“yellow-in-the-original-image” dotted lines) across 800 μm of rostral to caudal embryonic brain sections of E14.5 offspring from SPF, ABX and BD-colonized dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF, 7 ABX, 4 BD dams). Data are presented as mean±SEM. Data shown for SPF and ABX are as displayed in  FIGS. 1A-1M, 10A-10M, 2A-2D, 3A -I. *p&lt;0.05, **p&lt;0.01, ****p&lt;0.0001, n. s.=not statistically significant. 
         FIGS. 12A-12I : The maternal microbiota modulates fetal brain metabolites during pregnancy.  12 A, Unsupervised hierarchical clustering of 753 maternal serum metabolites, classified by metabolite super pathway (n=6 dams per group).  12 B, Principal component analysis of 753 metabolites detected in maternal serum metabolomes from SPF, ABX, GF, and Sp-colonized dams on E14.5 (n=6 dams per group)  12 C, Principal component analysis of 567 metabolites detected in fetal brain metabolomes from E14.5 offspring of SPF, ABX, GF, and Sp-colonized dams (n=offspring from 6 dams per group).  12 D, Volcano plot of significantly regulated metabolites in SPF vs ABX (left) and SPF v GF (right). Orange dots (in the original image) indicate log 2fold&gt;0.5. Red dots (in the original image) indicate p-value&lt;0.05. Green dots (in the original image) indicate metabolites that are log 2fold&gt;0.5 and p-value&lt;0.05 (ANOVA with contrasts, n=offspring from 6 dams per group).  12 E, Volcano plot of significantly regulated metabolites in Sp vs ABX (left) and Sp v GF (right). Orange dots (in the original image) indicate log 2fold&gt;0.5. Red dots (in the original image) indicate p-value&lt;0.05. Green dots (in the original image) indicate metabolites that are log 2fold&gt;0.5 and p-value&lt;0.05 (ANOVA with contrasts, n=offspring from 6 dams per group).  12 F, Amino acid, lipid and xenobiotic metabolites significantly dysregulated in fetal brains of E14.5 offspring from ABX-treated dams compared to SPF controls (p&lt;0.05; One-Way ANOVA, n=offspring from 6 dams per group).  12 G, Amino acid, lipid and xenobiotic metabolites significantly dysregulated in fetal brains of E14.5 offspring from ABX-treated dams compared to Sp controls (p&lt;0.05; One-Way ANOVA, n=offspring from 6 dams per group).  12 H, Random Forest classification of top 30 metabolites in fetal brain that discriminate between maternal colonization with SPF and Sp microbiota compared to ABX and GF. Red highlight (in the original image) indicates select metabolites with &gt;2-fold decrease in ABX and GF compared to SPF and Sp (n=offspring from 6 dams per group).  12 I, Select metabolites significantly decreased in fetal brains from E14.5 embryos of ABX and GF dams versus SPF and Sp dams. (One-way ANOVA with Tukey&#39;s, n=offspring from 6 dams per group). Data are presented as mean±SEM. **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001. 
         FIGS. 13A-13C : The maternal microbiota modulates maternal serum metabolites during pregnancy.  13 A, Random Forest classification of top 30 metabolites in maternal serum that discriminate between maternal colonization with SPF and Sp compared to ABX and GF. Red font (in the original image) indicates metabolites similarly regulated in both maternal serum and fetal brain from SPF and Sp compared to ABX and GF conditions (n=6 dams per group).  13 B, Relative concentrations of N, N, N-trimethyl-5-aminovalerate, trimethylamine N-oxide, imidazole propionate, hippurate, and 3-indoxyl-sulfate in maternal sera of SPF, ABX, GF, and Sp dams (One-way ANOVA with Tukey&#39;s; n=6 dams per group).  13 C, Amino acid, lipid and xenobiotic metabolites significantly dysregulated in fetal brains of E14.5 offspring from GF dams compared to SPF controls (left) and GF dams compared to Sp dams (right) (p&lt;0.05; One-way ANOVA, n=offspring from 6 dams per group). Data are presented as mean±SEM. *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001, n. s.=not statistically significant. 
         FIGS. 14A-14I : The maternal microbiota modulates metabolites that promote fetal thalamocortical axonogenesis and adult sensory behavior.  14 A, Schematic of axon outgrowth assay with individual metabolite supplementation.  14 B, Representative fluorescence images of axon outgrowth from ABX thalamic explants proximal to an ABX striatal explant (top left), and supplemented with i) vehicle (top left), ii) Trimethylamine N-oxide (TMAO, 1 nM) iii) 5-aminovalerate (5-AV, 1 nM), iv) imidazole propionate (IP, 1 nM), v) 3-indoxyl-sulfate (3-IS, 1 nM) or vi) Hippurate (HIP, 1 nM). Scale bar=250 μm.  14 C, Number of axons per 200 μm of thalamic perimeter proximal to striatal explant (One-way ANOVA with Tukey&#39;s, n=offspring from 14 SPF+SPF, 13 ABX+ABX, 7 TMAO, 7 5-AV, 7 IP, 7 3-IS, 8 HIP dams).  14 D, Representative immunofluorescence images of Netrin-G1a (magenta in the original image) and L1 (cyan in the original image) staining in embryonic brain sections (rostral to caudal) from E14.5 offspring of ABX dams treated with vehicle or 4-microbial metabolites (4-MM: TMAO, 5-AV, IP, and HIP). Scale bar=500 μm.  14 E, Average Netrin-G1a fluorescence intensity per matched area of region of interest (ROI) (“yellow-in-the-original-image” dotted lines) across 800 μm of rostral to caudal embryonic brain sections of E14.5 offspring from ABX dams treated with vehicle or 4-MM. (Two-way ANOVA with Tukey&#39;s, n=offspring from 8 dams per group).  14 F, Average L1 fluorescence intensity of L1 per matched area of ROI (“yellow-in-the-original-image” dotted lines) across 800 μm of rostral to caudal embryonic brain sections of E14.5 offspring from ABX dams treated with vehicle or 4-MM. (Two-way ANOVA with Tukey&#39;s, n=offspring from 8 dams per group).  14 G, Experimental timeline for ABX+Veh and ABX+4-MM groups.  14 H, Force filament to induce 50% paw withdrawal in adult offspring of SPF, ABX, ABX+Veh, and ABX+4-MM dams (One-way ANOVA with Tukey&#39;s, n=offspring from 5 SPF, 7 ABX, 6 ABX+Veh, 7 ABX+4-MM dams).  14 I, Left: Latency to contact the adhesive tape in adult offspring of SPF, ABX, ABX+Veh and ABX+4-MM dams (One-way ANOVA with Tukey&#39;s, n=offspring from 6 SPF, 6 ABX, 5 ABX+Veh, 5 ABX+4-MM dams). Middle: Latency to remove the adhesive tape after first contact in offspring of SPF, ABX, ABX+Veh and ABX+4-MM dams (One-way ANOVA with Tukey&#39;s, n=offspring from 6 SPF, 6 ABX, 5 ABX+Veh, 5 ABX+4-MM dams). Right: Pairwise comparison of latency to contact and latency to remove in offspring of SPF, ABX, ABX+Veh and ABX+4-MM dams (Two-way ANOVA with Sidak&#39;s, n=offspring from 6 SPF, 6 ABX, 5 ABX+Veh, 5 ABX+4-MM dams). Data shown for SPF and ABX as reference controls are as presented in  FIGS. 1A-1M .  6 A- 6 G, and  10 A- 10 M. Data are presented as mean±SEM. *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001, n. s.=not statistically significant. 
         FIGS. 15A-15D : Dose effects of microbiome-dependent metabolites on thalamocortical axon outgrowth.  15 A, Number of axons per 200 μm of thalamic perimeter proximal to striatal explant from i) SPF thalamic explant proximal to an SPF striatal explant (“SPF+SPF St”, left), as positive control ii) ABX thalamic explant proximal to an ABX striatal explant (“ABX+ABX St”), as negative control, and iii) ABX+ABX St, supplemented with 1 nM, 100 nM, 10 uM of metabolites: trimethylamine N-oxide (TMAO), 5-aminovalerate (5-AV), imidazole propionate (IP), 3-indoxyl-sulfate (3-IS) or Hippurate (HIP). (One-way ANOVA with Tukey&#39;s, n=offspring from 14 SPF+SPF; 13 ABX+ABX; 7, 6, 7 TMAO; 3, 5, 7 5-AV; 5, 7, 7 IP; 3, 7, 7 3-IS; 6, 7, 8 HIP dams).  15 B, Length of axons per 200 μm of thalamic perimeter proximal to striatal explant from i) SPF+SPF St as positive control ii) ABX+ABX St, as negative control, and iii) ABX+ABX St, supplemented with 1 nM, 100 nM, 10 1.1M of metabolites: TMAO, 5-AV, IP, 3-IS or HIP. (One-way ANOVA with Tukey&#39;s, n=offspring from 14 SPF+SPF; 12 ABX+ABX; 7, 6, 6 TMAO; 3, 5, 6 5-AV; 5, 7, 6 IP; 3, 7, 4 3-IS; 6, 7, 7 HIP dams).  15 C, Number of axons per 200 μm of thalamic perimeter proximal to hypothalamic explant (Hy) from i) SPF+SPF Hy, as positive control ii) ABX+ABX Hy as negative control, and iii) ABX+ABX Hy, supplemented with 1 nM, 100 nM, 10 uM of metabolites: TMAO, 5-AV, IP, 3-IS or HIP. (One-way ANOVA with Tukey&#39;s, n=offspring from 14 SPF+SPF; 10 ABX+ABX; 6, 6, 7 TMAO; 3, 5, 7 5-AV; 3, 6, 7 IP; 3, 7, 5 3-IS; 5, 7, 8 HIP dams).  15 D, Length of axons per 200 μm of thalamic perimeter proximal to hypothalamic explant from i) SPF+SPF Hy as positive control ii) ABX+ABX Hy as negative control, and iii) ABX+ABX Hy, supplemented with 1 nM, 100 nM, 10 uM of metabolites: TMAO, 5-AV, IP, 3-IS or HIP. (One-way ANOVA with Tukey&#39;s, n=offspring from 14 SPF+SPF; 9 ABX+ABX; 6, 6, 6 TMAO; 3, 5, 6 5-AV; 3, 7, 6 IP; 3, 7, 4 3-IS; 5, 7, 7 HIP dams). Data are presented as mean±SEM. *p&lt;0.05. **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001, n. s.=not statistically significant. 
         FIGS. 16A-16D : Netrin-G1a thalamocortical axons in embryonic brains of E14.5 offspring from metabolite supplementation dams.  16 A, Immunofluorescence images of Netrin-G1a in four independent embryonic brain sections from E14.5 offspring of ABX+vehicle and ABX+4-MM dams at 200 μm intervals. Scale bar: 500 μm.  16 B, Total Netrin-G1a fluorescence intensity across 800 μm of rostral to caudal sections of E14.5 embryonic brains from ABX+vehicle and ABX+4-MM dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 8 dams per group).  16 C, Average area of Netrin-G1a-positive staining across 800 μm of rostral to caudal embryonic brain sections of E14.5 offspring from ABX+vehicle and ABX+4-MM dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 8 dams per group).  16 D, Average DAPI fluorescence intensity normalized to per matched area of region of interest (“yellow-in-the-original-image” dotted lines) in 800 μm of rostral to caudal embryonic brain sections of E14.5 offspring from ABX+vehicle and ABX+4-MM dams. (Two-way ANOVA with Tukey&#39;s, n=offspring from 8 dams per group). Data are presented as mean±SEM. *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001, n. s.=not statistically significant. 
         FIGS. 17A-17F : Absence of sex differences in behavioral performance of offspring from metabolite-treated dams.  17 A, Force filament required to induce 50% paw withdrawal in adult offspring of SPF, ABX, ABX+Veh, ABX+4-MM dams (One-way ANOVA with Tukey&#39;s, n=10 SPF, 23 ABX, 19 ABX+Veh, 29 ABX+4-MM offspring).  17 B, Latency to contact the adhesive tape, in adult offspring of SPF, ABX, ABX+Veh, ABX+4-MM dams (One-way ANOVA with Tukey&#39;s, n=25 SPF, 19 ABX, 19 ABX+Veh, 29 ABX+4-MM offspring).  17 C, Latency to remove the adhesive tape after first contact in adult offspring of SPF, ABX, and Sp dams (One-way ANOVA with Tukey&#39;s, n=25 SPF, 19 ABX, 19 ABX+Veh, 29 ABX+4-MM offspring).  17 D, Force filament to induce 50% paw withdrawal in male and female adult offspring of SPF, ABX, ABX+Veh, and ABX+4-MM dams. Male and female comparisons per litter (left) or individual offspring (right). (Two-way ANOVA with Tukey&#39;s, n=10 male, 10 female SPF; 7 male, 16 female ABX; 9 male, 10 female ABX+Veh; 13 male, 16 female ABX+4-MM dams).  17 E, Latency to contact the adhesive tape, in male and female adult offspring of SPF, ABX, ABX+Veh, ABX+4-MM dams. Male and female comparisons per litter (left) or individual offspring (right). (Two-way ANOVA with Tukey&#39;s, n=15 male, 10 female SPF; 4 male, 15 female ABX; 6 male, 11 female ABX+Veh; 11 male, 16 female ABX+4-MM dams).  17 F, Latency to remove the adhesive tape after first contact in male and female adult offspring of SPF, ABX, and Sp dams. Male and female comparisons per litter (left) or individual offspring (right). (Two-way ANOVA with Tukey&#39;s, n=15 male, 10 female SPF; 4 male, 15 female ABX; 6 male, 11 female ABX+Veh; 11 male, 16 female ABX+4-MM dams). Data are presented as mean±SEM. n. s=not statistically significant. 
         FIG. 18 : A schematic depicting that the maternal microbiome mediates brain development and behaviours. 
     
    
    
     DETAILED DESCRIPTION 
     In some embodiments, the methods of the present disclosure are directed to promoting healthy neural development in an unborn baby, for example by administering to a subject (e.g., a maternal subject gestating the unborn baby, a female subject who plans to, expects to, or suspects of being pregnant) a composition, a bacterial composition, or both as disclosed herein. 
     In some embodiments, the methods of the present disclosure are directed to methods of conditioning a female subject for fostering healthy neural development in offspring, for example by administering to the subject a composition, a bacterial composition, or both as disclosed herein. 
     A composition that can be administered in these methods may comprise trimethylamine N-oxide (TMAO), 5-aminovalerate (5-AV), imidazole propionate (IP), hippurate (HIP), or a combination thereof (e.g., 5-AV and IP; 5-AV, IP, and TMAO; all 4 (4-MM)). 
     A bacterial composition that can be administered in these methods may comprise bacteria of the order Clostridiales. These bacteria can be of any of the following families: Lachnospiraceae, Ruminococcaceae, Clostridiaceae, or a combination thereof. In some embodiments, these bacteria are of any of the following genuses:  Clostridium , Dehalobacterium,  Ruminococcus, Coprococcus, Dorea, Oscillospira , or a combination thereof. In certain embodiments, these bacteria are spore-forming bacteria. 
     Healthy neural development can include healthy thalamocortical axon growth, healthy netrin-G1a+thalamocortical axogenesis, healthy tactile sensory development, or a combination thereof. 
     The disclosed compositions can be administered at various times. For example, they can be administered at least once (e.g., once during the full period, twice during the full period, once a day) during a period that runs from the first day of an expected-but-missed menstruation to a day that is two months after said first day. An alternative timing can be a period that runs from the second day of the expected-but-missed menstruation to a day that is 37 days after said second day (e.g., which for humans corresponds approximately to the mouse period from E7.5 to E14.5, which in units of days post conception (dpc) can be from 17 dpc to 52 dpc, at least in some subjects). Such timings can be useful to female subjects who prefer not to or cannot get tested for pregnancy though a professional facility. The administration time can also be at least once during a two-month period that ends with the day of an expected conception for the female subject. Such a timing can be useful for a subject who is planning pregnancy. The timing is, in some embodiments, at least once within the first trimester, second trimester, third trimester, or a combination thereof. More specific periods include the period that runs from the start of the third week after conception to the end of the eighth week after conception, and the period that runs from the 17 th  dpc to the 52 nd  dpc. 
     The disclosed methods can also be used to reduce adverse effects of antibiotic treatment on an unborn baby in a pregnant subject. For example, administering to the pregnant subject a composition that comprises trimethylamine N-oxide (TMAO), 5-aminovalerate (5-AV), imidazole propionate (IP), hippurate (HIP), or a combination thereof can promote healthy neural development, at least in comparison to a lack of such administration, in the unborn baby. 
     In certain embodiments, the methods of the present disclosure are directed to methods for selecting a female subject for conditioning to foster healthy neural development in offspring. These methods include determining that a compound has a level in a serum sample from the female subject that is at most 10%, 20%, 30%, 40%, 50%, 60%, or 70% of its level in a control serum sample representative of a healthy female subject, that bacteria of the order Clostridiales have a total level in a fecal sample from the female subject that is at most 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 14%, 16%, 18%, or 20% of their total level in a control fecal sample representative of a healthy female subject, or both, and selecting the female subject for conditioning to foster healthy neural development in offspring. In some embodiments, these criteria can be relaxed. For example, even if a subject has levels (of the compound, of the bacteria) that are similar to those of a healthy control, the subject may still be selected for treatment (e.g., with the bacterial compositions, which can be part of the normal gastrointestinal microbiome of a human) as a prophylactic measure. 
     In various embodiments, offspring can include babies carried by a surrogate mother, in which the baby need not be the biological offspring of the gestating female. 
     In these methods of selecting a female subject, the compound can be 2-(4-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate sulfate; 3-indoxyl sulfate; 3-phenylpropionate (hydrocinnamate); 7-ketodeoxycholate; alpha-ketoglutaramate; alpha-muricholate; beta-muricholate; biotin; deoxycholate; hippurate; imidazole propionate; indolepropionate; N,N,N-trimethyl-5-aminovalerate; p-cresol sulfate; phenylpropionylglycine; pyrraline; stachydrine; taurodeoxycholate; taurohyodeoxycholic acid; trimethylamine N-oxide; ursodeoxycholate; or a combination thereof. Alternatively, the compound can be 3-indoxyl sulfate; biotin; hippurate; imidazole propionate; N,N,N-trimethyl-5-aminovalerate; pyrraline; stachydrine; trimethylamine N-oxide; or a combination thereof. The bacteria, in some of these embodiments, includes bacteria of the genus  Clostridium , genus Dehalobacterium, genus  Ruminococcus , genus  Coprococcus , genus  Dorea , genus  Oscillospira , or a combination thereof. Once a female subject is selected, she can be treated by administering to her a composition, bacterial composition, or both as provided herein. 
     In certain embodiments, the methods of the present disclosure are directed to promoting healthy neural development in a fetus, such as by administering to a maternal subject gestating the fetus (or to a female subject) a composition as described herein. Preferably, the method results in the fetus exhibiting a lesser degree of impaired neural development relative to a fetus gestated by similar a maternal subject (e.g., a maternal subject having a similar or identical maternal microbiome) not receiving the composition. Preferably, the method results in an increase in one or more of fetal brain gene expression, fetal axonogenesis (e.g., fetal thalamocortical axonogenesis), fetal axon development, and adult tactile sensory behavior relative to a fetus gestated by similar a maternal subject (e.g., a maternal subject having a similar or identical maternal microbiome) not receiving the composition. 
     In additional embodiments of any of the aspects disclosed herein, the conjugate base forms or the conjugate acid forms of the disclosed compounds can be used, either instead of or together with their conjugate form. For example, in certain embodiments, hippuric acid can be used instead of or in addition to hippurate, imidazolepropionic acid can be used instead of or in addition to imidazole propionate, and 5-aminovaleric acid can be used instead of or in addition to 5-aminovalerate. 
     In certain embodiments, the methods of the present disclosure are directed to inhibiting development of a disease or disorder in a fetus, e.g., by administering to a maternal subject gestating the fetus (or to a female subject) a composition as described herein. Preferably, the method results in the fetus exhibiting a lesser degree of development of the disease or disorder (e.g., a metabolic disorder, a cardiovascular disorder, a cerebrovascular disorder, stroke, Alzheimer&#39;s disease, schizophrenia, depression, or autism) during the fetal period and throughout the lifetime of the eventual child, adolescent, and adult, relative to a fetus gestated by a similar maternal subject (e.g., a maternal subject having a similar or identical maternal microbiome) not receiving the composition. 
     In certain embodiments, the methods further comprise administering the composition to the maternal subject or a female subject prior to gestation. In certain embodiments, the female subject is a fertile, ovulating female subject. In certain embodiments, the female subject is a female subject seeking to implant an embryo. 
     In certain embodiments, the composition comprises a compound selected from trimethylamine-N-oxide (TMAO), N,N,N-trimethyl-5-aminovaleric acid (TMAV), imidazole propionic acid (IP), 3-indoxyl sulfuric acid (3-IS), hippuric acid (HIP), perfluorooctanesulfonic acid (PFOS), 3-sulfo-L-alanine, alpha-ketoglutaramic acid, 4-hydroxyglutamic acid, extoine, stachydrine, biotin, pyroglutamine, chiro-inositol, N1-methyl-2-pyridone-5-carboxamide, O-sulfo-L-tyrosine, 2′deoxyuridine, pyrraline, N-delta-acetylornithine, phenyl sulfuric acid, phenylacetylglycine, anserine, homostachydrine, serine, N1-methyl-4-pyridone-3-carboxamide, methyl glycopyranoside (alpha+beta), 3-carboxy-1-methylpyridin-1-ium, hypotaurine, 1,5-anhydroglucitol (1,5-AG), 1-oleoyl-2-linoleoyl-GPC (18:1/18:2), methionine, glutamine, malic acid, pantothenic acid, 5,6-dihydrouridine, ceramide (d18:1/17:0 d17:1/18.0) N6-methyllysine, allantoin, N2-acetyllysine, N-acetylglutamine, stearoylcarnitine (C18), arachidoylcarnitine (C20), arabitol, xylitol, 1-methylhistamine, xanthosine, xanthine, 1-ribosyl-imidazoleacetic acid, 5-methyl-2′-deoxycytidine, sphingomyelin (d18:0/20:0, d16:0/22:0), 1-methyl-4-imidazoleacetic acid, inosine 5′-monophosphoric acid (IMP), 1,2-distearoyl-GPC (18:0/18:0), 3-methylcytidine, pipecolate, N-stearoyl-sphingadienine (d18:2/18:0), homoserine, carnosine, 1-palmitoyl-GPI (16:0), 1-stearoyl-GPI (18:0), N6-succinyladenosine, 2′-deoxycytidine, stearoyl-docosahexaenoyl-glycerol (18:0/22:6), trigonelline (N′-methylnicotinate), hydroxyasparagine, gamma-glutamylglutamic acid, 2-palmitoylglycerol (16:0), ceramide (d18:1/17:0, d17:1/18:0), thiamin (Vitamin B1), N6-methyllysine, N6,N6-dimethyllysine, 3-hydroxy-3-methylglutaric acid, campesterol, allantoin, stachydrine, N2-acetyllysine, phenyllactic acid (PLA), gamma-glutamyltryptophan, N-palmitoyl-sphingosine (d18:1/16:0), O-sulfo-L-tyrosine, indolelactic acid, gamma-glutamylglutamine, N-acetylglucosamine 6-phosphoric acid, 1-oleoyl-GPS (18:1), 3-hydroxypalmitoylcarnitine, myo-inositol, behenoyl sphingomyelin (d18:1/22:0), maltotetraose, maltotriose, N-acetylglucosamine/N-acetylgalactosamine, N1-methyladenosine, uracil, 1-oleoyl-GPI (18:1), sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0), 3-ureidopropionic acid, 5-oxoproline, gamma-glutamyltyrosine, 1-(1-enyl-stearoyl)-GPE (P-18:0), cytidine 2′,3′-cyclic monophosphoric acid, 2′-deoxyguanosine 5′-monophosphoric acid (dGMP), thymidine, N6,N6,N6-trimethyllysine, 1-palmitoyl-GPC (16:0), 1-(1-enyl-palmitoyl)-GPE (P-16:0), N-stearoyl-sphinganine (d18:0/18:0), N-arachidoyl-sphingosine (d18:1/20:0), 3′-dephosphocoenzyme A, 5-hydroxylysine, arabonic acid/xylonic acid, 1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6), glutamine, 1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0), N-behenoyl-sphingadienine (d18:2/22:0), xylulose 5-phosphoric acid, 1-oleoyl-GPC (18:1), 1-stearoyl-GPE (18:0), glycerol 3-phosphoric acid, N-stearoyl-sphingosine (d18:1/18:0), 7-methylguanine, N2,N2-dimethylguanosine, N-acetylglutamine, methionine, pro-hydroxy-pro, dihydroxyacetone phosphoric acid (DHAP), 1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6), sphingomyelin (d18:1/20:0, d16:1/22:0), uric acid, adenylosuccinic acid, cystathionine, spermine, mannitol/sorbitol, 2-hydroxyadipic acid, N-palmitoyl-sphinganine (d18:0/16:0), sphingomyelin (d18:0/18:0, d19:0/17:0), sphingomyelin (d18:1/24:1, d18:2/24:0), alpha-hydroxyisovaleric acid, citrulline, ribulonic acid/xylulonic acid, succinylcarnitine (C4-DC), ceramide (d16:1/24:1, d18:1/22:1), hypoxanthine, 5,6-dihydrouridine, gamma-aminobutyric acid (GABA), oleoyl ethanolamide, choline, 1-palmitoyl-GPE (16:0), palmitoyl-linoleoyl-glycerol (16:0/18:2), ceramide (d18:2/24:1, d18:1/24:2), cholesterol, 2′-O-methylcytidine, nicotinamide riboside, pantothenic acid, pyridoxal, N-acetylaspartic acid (NAA), C-glycosyltryptophan, methionine sulfoxide, spermidine, 1-palmitoyl-2-oleoyl-GPG (16:0/18:1), lignoceroyl sphingomyelin (d18:1/24:0), desmosterol, N1-methylinosine, cytidine, N-acetyl-aspartyl-glutamic acid (NAAG), sedoheptulose, galactonic acid, cytidine 5′-monophospho-N-acetylneuraminic acid, glycerophosphoinositol, uridine, salicylic acid, N-acetylglutamic acid, gamma-glutamyl-epsilon-lysine, glycerophosphoserine, 1-stearoyl-2-oleoyl-GPE (18:0/18:1), beta-alanine, 5-methylcytidine, methylphosphoric acid, imidazole lactic acid, sedoheptulose-7-phosphoric acid, 1-palmitoyl-2-stearoyl-GPE (16:0/18:0), guanosine 5′-diphosphoric acid (GDP), 3-ureidoisobutyric acid, tryptophan, isoleucine, methyl succinic acid, S-adenosylmethionine (SAM), taurine, gamma-glutamylthreonine, arabitol/xylitol, erythronic acid, fumaric acid, stearoylcarnitine (C18), deoxycarnitine, cytidine 5′-diphosphocholine, 1-stearoyl-2-arachidonoyl-GPC (18:0/20:4), 1-stearoyl-2-arachidonoyl-GPI (18:0/20:4), glycerophosphoglycerol, N6-carbamoylthreonyladenosine, flavin adenine dinucleotide (FAD), 2-oxoarginine, lactic acid, gulonic acid, phenylalanine, 3-(4-hydroxyphenyl)lactic acid, 2-hydroxyglutaric acid, palmitoleoyl ethanolamide, 1-palmitoyl-2-stearoyl-GPC (16:0/18:0), 1-stearoyl-2-oleoyl-GPC (18:0/18:1), palmitoyl-oleoyl-glycerol (16:0/18:1), betaine, N-acetylneuraminic acid, malic acid, phosphoethanolamine, 1-myristoyl-2-arachidonoyl-GPC (14:0/20:4), beta-citrylglutamic acid, 1-methylhistidine, leucine, ethylmalonic acid, prolylglycine, stearoyl-arachidonoyl-glycerol (18:0/20:4), orotidine, 5-(galactosylhydroxy)-L-lysine, N-acetylglucosaminylasparagine, eicosenoylcarnitine (C20:1), cytidine-5′-diphosphoethanolamine, glycosyl-N-stearoyl-sphingosine (d18:1/18:0), palmitoyl dihydrosphingomyelin (d18:0/16:0), sphingosine, inosine, guanosine 5′-monophosphoric acid (5′-GMP), dimethylglycine, N-acetylalanine, aspartic acid, creatine, ribitol, 2-methylcitric acid/homocitric acid, arachidoylcarnitine (C20), S-methylglutathione, 1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6), stearoyl sphingomyelin (d18:1/18:0), nicotinamide, N-formylmethionine, UDP-N-acetylglucosamine/galactosamine, glucoronic acid, 1,2-dipalmitoyl-GPE (16:0/16:0), pseudouridine, alanine, glutamic acid, 1-myristoyl-2-palmitoyl-GPC (14:0/16:0), 1,2-dipalmitoyl-GPC (16:0/16:0), 1-palmitoyl-2-oleoyl-GPC (16:0/18:1), sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1), glycerophosphoethanolamine, 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1), UDP-glucuronic acid, and 1-methylnicotinamide, or a salt thereof, or a combination thereof. 
     In certain embodiments, the composition comprises a compound selected from trimethylamine-N-oxide (TMAO), N,N,N-trimethyl-5-aminovaleric acid (TMAV), imidazole propionic acid (IP), 3-indoxyl sulfuric acid (3-IS), hippuric acid (HIP), perfluorooctanesulfonic acid (PFOS), 3-sulfo-L-alanine, alpha-ketoglutaramic acid, 4-hydroxyglutamic acid, extoine, stachydrine, biotin, pyroglutamine, chiro-inositol, N1-methyl-2-pyridone-5-carboxamide, O-sulfo-L-tyrosine, 2′deoxyuridine, pyrraline, N-delta-acetylornithine, phenylsulfuric acid, phenylacetylglycine, anserine, homostachydrine, serine, N1-methyl-4-pyridone-3-carboxamide, methyl glycopyranoside (alpha+beta), 3-carboxy-1-methylpyridin-1-ium, hypotaurine, 1,5-anhydroglucitol (1,5-AG), 1-oleoyl-2-linoleoyl-GPC (18:1/18:2), methionine, glutamine, malic acid, pantothenic acid, 5,6-dihydrouridine, ceramide (d18:1/17:0 d17:1/18.0) N6-methyllysine, allantoin, N2-acetyllysine, N-acetylglutamine, stearoylcarnitine (C18), arachidoylcarnitine (C20), arabitol, and xylitol, or a salt thereof, or a combination thereof. In certain embodiments, the composition comprises a compound selected from 3-sulfo-L-alanine, TMAV, IP, TMAO, 3-IS, phenylsulfuric acid, stachydrine, hippuric acid, homostachydrine, pyrraline, alpha-ketoglutaramic acid, O-sulfo-L-tyrosine, methionine, 3-carboxy-1-methylpyridin-1-ium, biotin, glutamine, malic acid, pantothenic acid, pyroglutamine, anserine, 5,6-dihydrouridine, phenylacetylglycine, ceramide (d18:1/17:0 d17:1/18.0), N6-methyllysine, allantoin, N2-acetyllysine, N-acetylglutamine, stearoylcarnitine (C18), arachidoylcarnitine (C20), arabitol, and xylitol, or a salt thereof, or a combination thereof. In certain embodiments, the composition comprises a compound selected from methionine, glutamine, malic acid, pantothenic acid, 5,6-dihydrouridine, ceramide (d18:1/17:0 d17:1/18.0), N6-methyllysine, allantoin, N2-acetyllysine, N-acetylglutamine, stearoylcarnitine (C18), arachidoylcarnitine (C20), arabitol, and xylitol, or a salt thereof, or a combination thereof. In certain embodiments, the composition comprises a compound selected from TMAO, TMAV, HIP, IP, and 3-IS, or a salt thereof, or a combination thereof. In certain embodiments, the composition comprises a compound selected from TMAO, TMAV, and HIP, or a salt thereof, or a combination thereof. In certain embodiments, the composition comprises a compound selected from TMAO, TMAV, IP, and 3-IS, or a salt thereof, or a combination thereof. In certain embodiments, the composition comprises a compound selected from TMAO, TMAV, IP, and HIP, or a salt thereof, or a combination thereof. In certain embodiments, the composition comprises a compound selected from TMAV or TMAO, or a salt thereof, or a combination thereof. In certain embodiments, the composition comprises the compound TMAO or a salt thereof. 
     In some embodiments, the present invention is drawn to a composition comprising at least one bacterial species or bacterial strain (e.g., a probiotic bacterial strain) capable of promoting healthy neural development in a fetus and/or inhibiting development of a disease or disorder in a subject, optionally wherein the at least one bacterial species or bacterial strain is alive and capable of proliferation. Such bacteria (e.g., probiotic bacteria) inhibit one or more adverse effects of maternal microbiota depletion (e.g., in ABX subjects) on neural development, e.g., fetal brain gene expression, thalamocortical axon outgrowth, and offspring sensory behavior. In some embodiments, such bacteria restore expression of one or more genes relevant to axon guidance. In certain embodiments, the at least one bacterial species or bacterial strain is a bacterial species found in a maternal microbiome. In some embodiments, the one or more bacterial species is a spore-forming bacterial species. 
     In certain embodiments, the one or more bacteria in the composition are spore-forming bacteria. In certain embodiments, the one or more spore-forming bacteria are selected from order Clostridiales (e.g., family Lachnospiraceae, family Clostridiaceae, family Ruminococcaceae, family Dehalobacteriaceae), order Turicibacterales (e.g., family Turicibacteraceae), order Anaeroplasmatales (e.g., family Anaeroplasmataceae), order Erysipelotrichales (e.g., family Erysipelotrichaceae), and order RF39, or a combination thereof. In certain embodiments, the one or more spore-forming bacteria are selected from order Clostridiales. 
     In certain embodiments, the one or more bacteria in the composition are selected from order Lactobacillales (e.g., genus  Enterococcus ), order Clostridiales (e.g., family Clostridiaceae, family Peptostreptococcaceae, family Lachnospiraceae), order Turicibacterales (e.g., genus  Turicibacter ), order Erysipelotrichales (e.g., genus  Eubacterium ), order Enterobacteriales, order Bacteroidales (e.g., genus  Bacteroides ), or a combination thereof. In certain embodiments, the one or more bacteria are selected from order Bacteroidales (e.g., genus  Bacteroides ). 
     In certain embodiments, the one or more bacteria in the composition are selected from phylum Firmicutes, phylum Tenericutes, phylum Bacteroidetes, or a combination thereof. In certain embodiments, the one or more bacteria in the composition from phylum Firmicutes comprises one or more bacteria selected from class Clostridia, class Bacilli (e.g., order Lactobacillales, order Turicibacterales), class Erysipelotrichi, and class Gammaproteobacteria. In certain embodiments, the one or more bacteria in the composition from phylum Bacteroidetes comprises one or more bacteria selected from genus  Bacteroides  (e.g.,  B. thetraiotaomicron, B. uniformis, B. vulgatus, B. ovatus, B. fragilus ). In certain embodiments, the one or more bacteria in the composition from phylum Tenericutes comprises one or more bacteria selected from class Mollicutes (e.g., order Anaeroplasmatales, order RF39). 
     Definitions 
     “Impaired neural development,” as used herein, refers to abnormalities in brain function and behavior, in offspring. Examples of impaired neural development include, but are not limited to, impairments in fetal brain gene expression, fetal axonogenesis (such as fetal thalamocortical axonogenesis), and/or adult tactile sensory behavior (e.g., tactile hyposensitivity in sensorimotor behavioral tasks). Examples of “healthy neural development,” as used herein, include, but are not limited to, healthy development in fetal brain gene expression, fetal axonogenesis, fetal axon development, and/or adult tactile sensory behavior. 
     “Microbiome,” as used herein, refers to the microorganisms in a given environment, such as the body or a part of the body. The “maternal microbiome,” as used herein, refers to the microorganisms in a maternal subject (i.e., a pregnant or gestating subject), particularly in the gut of the maternal subject. The gut microbiome modulates the bioavailability of hundreds of biochemicals in the circulating blood. During pregnancy, the maternal gut environment supplies nutrients and growth factors, from the maternal diet and other nutritional intake, to nurture offspring growth. 
     A “depleted” maternal microbiome is characterized by a reduced level of one or more microbial species (e.g., one or more bacterial species), such as 95%, 90%, 85%, 80%, 75%, 70%, 65%, 60%, 55%, 50%, 45%, 40%, 35%, 30%, 25%, 20%, 15%, 10%, 5%, 4%, 3%, 2%, 1%, 0.5%, or 0.1% of the level relative to a maternal subject without a depleted maternal microbiome. 
     “Germ-free” (GF) subjects, as used herein, are subjects with no microorganisms living in or on them. “Antibiotic-treated” (ABX) subjects, as used herein, are subjects treated with one or more antibiotic compounds, many representative examples of which are known in the art. 
     The term “subject” to which administration is contemplated includes, but is not limited to, humans (i.e., a male or female of any age group, e.g., a pediatric subject (e.g., infant, child, adolescent) or adult subject (e.g., young adult, middle-aged adult or senior adult)) and/or other primates (e.g., cynomolgus monkeys, rhesus monkeys); and/or mammals, including commercially relevant mammals such as cattle, pigs, horses, sheep, goats, cats, and/or dogs. Preferred subjects are humans. 
     An “ovulating” female subject, as used herein, refers to a female subject having a regular cycle of menses, e.g., a female between menarche and menopause that is not employing hormonal birth control that inhibits ovulation. A “fertile” female subject, as used herein, refers to an ovulating female subject able to conceive offspring. 
     As used herein, a therapeutic that “prevents” a disorder or condition refers to a compound or composition that, in a statistical sample, reduces the occurrence of the disorder or condition in the treated sample relative to an untreated control sample, or delays the onset or reduces the severity of one or more symptoms of the disorder or condition relative to the untreated control sample. 
     The term “treating” includes prophylactic and/or therapeutic treatments. The term “prophylactic or therapeutic” treatment is art-recognized and includes administration to the subject of one or more of the disclosed compositions. If it is administered prior to clinical manifestation of the unwanted condition (e.g., disease or other unwanted state of the subject) then the treatment is prophylactic (i.e., it protects the subject against developing the unwanted condition), whereas if it is administered after manifestation of the unwanted condition, the treatment is therapeutic (i.e., it is intended to diminish, ameliorate, or stabilize the existing unwanted condition or side effects thereof). 
     The term “prodrug” is intended to encompass compounds which, under physiologic conditions, are converted into therapeutically active agents. A common method for making a prodrug is to include one or more selected moieties which are hydrolyzed under physiologic conditions to reveal the desired molecule. In other embodiments, the prodrug is converted by an enzymatic activity of the host animal. For example, esters or carbonates (e.g., esters or carbonates of alcohols or carboxylic acids) and esters or amides of phosphates and phosphonic acids are preferred prodrugs of the present invention. 
     As used herein, the term “about” is defined as being close to as understood by one of ordinary skill in the art. In one non-limiting embodiment, the term “about” is defined to be within 10%, preferably within 5%, more preferably within 1%, and most preferably within 0.5%. 
     As used herein, “stably stored” or “storage-stable” refer to a composition in which cells are able to withstand storage for extended periods of time (e.g., at least one month, or two, three, four, six, or twelve months or more) with a less than 95%, 90%, 80%, 70%, 60%, 50%, 40%, 30%, 20%, 15%, 10%, 5%, or 1% decrease in cell viability. 
     As used herein, the phrase “conjoint administration” refers to any form of administration of two or more different therapeutic compounds such that the second compound is administered while the previously administered therapeutic compound is still effective in the body (e.g., the two compounds are simultaneously effective in the subject, which may include synergistic effects of the two compounds). For example, the different therapeutic compounds can be administered either in the same formulation or in a separate formulation, either concomitantly or sequentially. In certain embodiments, the different therapeutic compounds can be administered within one hour, 12 hours, 24 hours, 36 hours, 48 hours, 72 hours, or a week of one another. Thus, a subject who receives such treatment can benefit from a combined effect of different therapeutic compounds. 
     Bacterial Compositions 
     In certain aspects, provided herein are bacterial compositions that include bacteria of the order Clostridiales. In some embodiments, the bacteria of the order Clostridiales include bacteria of the family Lachnospiraceae, family Ruminococcaceae, family Clostridiaceae, or a combination thereof. In certain embodiments, the bacteria of the order Clostridiales include bacteria of the genus  Clostridium , genus Dehalobacterium, genus  Ruminococcus , genus  Coprococcus , genus  Dorea , genus  Oscillospira , or a combination thereof. The bacteria of the order Clostridiales can be spore-forming bacteria. In some embodiments, the bacteria are selected from those presented in Table 2. 
     In certain aspects, provided herein are bacterial compositions comprising one or more bacteria and optionally a compound selected from trimethylamine-N-oxide (TMAO), N,N,N-trimethyl-5-aminovaleric acid (TMAV), imidazole propionic acid (IP), 3-indoxyl sulfuric acid (3-IS), hippuric acid (HIP), perfluorooctanesulfonic acid (PFOS), 3-sulfo-L-alanine, alpha-ketoglutaramic acid, 4-hydroxyglutamic acid, extoine, stachydrine, biotin, pyroglutamine, chiro-inositol, N1-methyl-2-pyridone-5-carboxamide, O-sulfo-L-tyrosine, 2′deoxyuridine, pyrraline, N-delta-acetylornithine, phenylsulfuric acid, phenylacetylglycine, anserine, homostachydrine, serine, N1-methyl-4-pyridone-3-carboxamide, methyl glycopyranoside (alpha+beta), 3-carboxy-1-methylpyridin-1-ium, hypotaurine, 1,5-anhydroglucitol (1,5-AG), 1-oleoyl-2-linoleoyl-GPC (18:1/18:2), methionine, glutamine, malic acid, pantothenic acid, 5,6-dihydrouridine, ceramide (d18:1/17:0 d17:1/18.0) N6-methyllysine, allantoin, N2-acetyllysine, N-acetylglutamine, stearoylcarnitine (C18), arachidoylcarnitine (C20), arabitol, xylitol, 1-methylhistamine, xanthosine, xanthine, 1-ribosyl-imidazoleacetic acid, 5-methyl-2′-deoxycytidine, sphingomyelin (d18:0/20:0, d16:0/22:0), 1-methyl-4-imidazoleacetic acid, inosine 5′-monophosphoric acid (IMP), 1,2-distearoyl-GPC (18:0/18:0), 3-methylcytidine, pipecolate, N-stearoyl-sphingadienine (d18:2/18:0), homoserine, carnosine, 1-palmitoyl-GPI (16:0), 1-stearoyl-GPI (18:0), N6-succinyladenosine, 2′-deoxycytidine, stearoyl-docosahexaenoyl-glycerol (18:0/22:6), trigonelline (N′-methylnicotinate), hydroxyasparagine, gamma-glutamylglutamic acid, 2-palmitoylglycerol (16:0), ceramide (d18:1/17:0, d17:1/18:0), thiamin (Vitamin B1), N6-methyllysine, N6,N6-dimethyllysine, 3-hydroxy-3-methylglutaric acid, campesterol, allantoin, stachydrine, N2-acetyllysine, phenyllactic acid (PLA), gamma-glutamyltryptophan, N-palmitoyl-sphingosine (d18:1/16:0), O-sulfo-L-tyrosine, indolelactic acid, gamma-glutamylglutamine, N-acetylglucosamine 6-phosphoric acid, 1-oleoyl-GPS (18:1), 3-hydroxypalmitoylcarnitine, myo-inositol, behenoyl sphingomyelin (d18:1/22:0), maltotetraose, maltotriose, N-acetylglucosamine/N-acetylgalactosamine, N1-methyladenosine, uracil, 1-oleoyl-GPI (18:1), sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0), 3-ureidopropionic acid, 5-oxoproline, gamma-glutamyltyrosine, 1-(1-enyl-stearoyl)-GPE (P-18:0), cytidine 2′,3′-cyclic monophosphoric acid, 2′-deoxyguanosine 5′-monophosphoric acid (dGMP), thymidine, N6,N6,N6-trimethyllysine, 1-palmitoyl-GPC (16:0), 1-(1-enyl-palmitoyl)-GPE (P-16:0), N-stearoyl-sphinganine (d18:0/18:0), N-arachidoyl-sphingosine (d18:1/20:0), 3′-dephosphocoenzyme A, 5-hydroxylysine, arabonic acid/xylonic acid, 1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6), glutamine, 1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0), N-behenoyl-sphingadienine (d18:2/22:0), xylulose 5-phosphoric acid, 1-oleoyl-GPC (18:1), 1-stearoyl-GPE (18:0), glycerol 3-phosphoric acid, N-stearoyl-sphingosine (d18:1/18:0), 7-methylguanine, N2,N2-dimethylguanosine, N-acetylglutamine, methionine, pro-hydroxy-pro, dihydroxyacetone phosphoric acid (DHAP), 1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6), sphingomyelin (d18:1/20:0, d16:1/22:0), uric acid, adenylosuccinic acid, cystathionine, spermine, mannitol/sorbitol, 2-hydroxyadipic acid, N-palmitoyl-sphinganine (d18:0/16:0), sphingomyelin (d18:0/18:0, d19:0/17:0), sphingomyelin (d18:1/24:1, d18:2/24:0), alpha-hydroxyisovaleric acid, citrulline, ribulonic acid/xylulonic acid, succinylcarnitine (C4-DC), ceramide (d16:1/24:1, d18:1/22:1), hypoxanthine, 5,6-dihydrouridine, gamma-aminobutyric acid (GABA), oleoyl ethanolamide, choline, 1-palmitoyl-GPE (16:0), palmitoyl-linoleoyl-glycerol (16:0/18:2), ceramide (d18:2/24:1, d18:1/24:2), cholesterol, 2′-O-methylcytidine, nicotinamide riboside, pantothenic acid, pyridoxal, N-acetylaspartic acid (NAA), C-glycosyltryptophan, methionine sulfoxide, spermidine, 1-palmitoyl-2-oleoyl-GPG (16:0/18:1), lignoceroyl sphingomyelin (d18:1/24:0), desmosterol, N1-methylinosine, cytidine, N-acetyl-aspartyl-glutamic acid (NAAG), sedoheptulose, galactonic acid, cytidine 5′-monophospho-N-acetylneuraminic acid, glycerophosphoinositol, uridine, salicylic acid, N-acetylglutamic acid, gamma-glutamyl-epsilon-lysine, glycerophosphoserine, 1-stearoyl-2-oleoyl-GPE (18:0/18:1), beta-alanine, 5-methylcytidine, methylphosphoric acid, imidazole lactic acid, sedoheptulose-7-phosphoric acid, 1-palmitoyl-2-stearoyl-GPE (16:0/18:0), guanosine 5′-diphosphoric acid (GDP), 3-ureidoisobutyric acid, tryptophan, isoleucine, methyl succinic acid, S-adenosylmethionine (SAM), taurine, gamma-glutamylthreonine, arabitol/xylitol, erythronic acid, fumaric acid, stearoylcarnitine (C18), deoxycarnitine, cytidine 5′-diphosphocholine, 1-stearoyl-2-arachidonoyl-GPC (18:0/20:4), 1-stearoyl-2-arachidonoyl-GPI (18:0/20:4), glycerophosphoglycerol, N6-carbamoylthreonyladenosine, flavin adenine dinucleotide (FAD), 2-oxoarginine, lactic acid, gulonic acid, phenylalanine, 3-(4-hydroxyphenyl)lactic acid, 2-hydroxyglutaric acid, palmitoleoyl ethanolamide, 1-palmitoyl-2-stearoyl-GPC (16:0/18:0), 1-stearoyl-2-oleoyl-GPC (18:0/18:1), palmitoyl-oleoyl-glycerol (16:0/18:1), betaine, N-acetylneuraminic acid, malic acid, phosphoethanolamine, 1-myristoyl-2-arachidonoyl-GPC (14:0/20:4), beta-citrylglutamic acid, 1-methylhistidine, leucine, ethylmalonic acid, prolylglycine, stearoyl-arachidonoyl-glycerol (18:0/20:4), orotidine, 5-(galactosylhydroxy)-L-lysine, N-acetylglucosaminylasparagine, eicosenoylcarnitine (C20:1), cytidine-5′-diphosphoethanolamine, glycosyl-N-stearoyl-sphingosine (d18:1/18:0), palmitoyl dihydrosphingomyelin (d18:0/16:0), sphingosine, inosine, guanosine 5′-monophosphoric acid (5′-GMP), dimethylglycine, N-acetylalanine, aspartic acid, creatine, ribitol, 2-methylcitric acid/homocitric acid, arachidoylcarnitine (C20), S-methylglutathione, 1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6), stearoyl sphingomyelin (d18:1/18:0), nicotinamide, N-formylmethionine, UDP-N-acetylglucosamine/galactosamine, glucoronic acid, 1,2-dipalmitoyl-GPE (16:0/16:0), pseudouridine, alanine, glutamic acid, 1-myristoyl-2-palmitoyl-GPC (14:0/16:0), 1,2-dipalmitoyl-GPC (16:0/16:0), 1-palmitoyl-2-oleoyl-GPC (16:0/18:1), sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1), glycerophosphoethanolamine, 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1), UDP-glucuronic acid, and 1-methylnicotinamide, or a salt thereof, or a combination thereof. 
     In certain aspects, provided herein are bacterial compositions comprising one or more bacteria and optionally a compound selected from trimethylamine-N-oxide (TMAO), N,N,N-trimethyl-5-aminovaleric acid (TMAV), imidazole propionic acid (IP), 3-indoxyl sulfuric acid (3-IS), hippuric acid (HIP), perfluorooctanesulfonic acid (PFOS), 3-sulfo-L-alanine, alpha-ketoglutaramic acid, 4-hydroxyglutamic acid, extoine, stachydrine, biotin, pyroglutamine, chiro-inositol, N1-methyl-2-pyridone-5-carboxamide, O-sulfo-L-tyrosine, 2′deoxyuridine, pyrraline, N-delta-acetylornithine, phenylsulfuric acid, phenylacetylglycine, anserine, homostachydrine, serine, N1-methyl-4-pyridone-3-carboxamide, methyl glycopyranoside (alpha+beta), 3-carboxy-1-methylpyridin-1-ium, hypotaurine, 1,5-anhydroglucitol (1,5-AG), 1-oleoyl-2-linoleoyl-GPC (18:1/18:2), methionine, glutamine, malic acid, pantothenic acid, 5,6-dihydrouridine, ceramide (d18:1/17:0 d17:1/18.0) N6-methyllysine, allantoin, N2-acetyllysine, N-acetylglutamine, stearoylcarnitine (C18), arachidoylcarnitine (C20), arabitol, and xylitol, or a salt thereof, or a combination thereof. In certain aspects, provided herein are bacterial compositions comprising one or more bacteria and optionally a compound selected from 3-sulfo-L-alanine, TMAV, IP, TMAO, 3-IS, phenylsulfuric acid, stachydrine, hippuric acid, homostachydrine, pyrraline, alpha-ketoglutaramic acid, O-sulfo-L-tyrosine, methionine, 3-carboxy-1-methylpyridin-1-ium, biotin, glutamine, malic acid, pantothenic acid, pyroglutamine, anserine, 5,6-dihydrouridine, phenylacetylglycine, ceramide (d18:1/17:0 d17:1/18.0), N6-methyllysine, allantoin, N2-acetyllysine, N-acetylglutamine, stearoylcarnitine (C18), arachidoylcarnitine (C20), arabitol, and xylitol, or a salt thereof, or a combination thereof. In certain embodiments, provided herein are bacterial compositions comprising one or more bacteria and optionally a compound selected from methionine, glutamine, malic acid, pantothenic acid, 5,6-dihydrouridine, ceramide (d18:1/17:0 d17:1/18.0), N6-methyllysine, allantoin, N2-acetyllysine, N-acetylglutamine, stearoylcarnitine (C18), arachidoylcarnitine (C20), arabitol, and xylitol, or a salt thereof, or a combination thereof. In certain embodiments, provided herein are bacterial compositions comprising one or more bacteria and optionally a compound selected from TMAO, TMAV, HIP, IP, and 3-IS, or a salt thereof, or a combination thereof. In certain embodiments, provided herein are bacterial compositions comprising one or more bacteria and optionally a compound selected from TMAO, TMAV, and HIP, or a salt thereof, or a combination thereof. In certain embodiments, provided herein are bacterial compositions comprising one or more bacteria and optionally a compound selected from TMAO, TMAV, IP, and 3-IS, or a salt thereof, or a combination thereof. In certain embodiments, provided herein are bacterial compositions comprising one or more bacteria and optionally a compound selected from TMAO, TMAV, IP, and HIP, or a salt thereof, or a combination thereof. In certain embodiments, provided herein are bacterial compositions comprising one or more bacteria and optionally a compound selected from TMAV or TMAO, or a salt thereof, or a combination thereof. In certain embodiments, provided herein are bacterial compositions comprising one or more bacteria and optionally TMAO or a salt thereof. In certain embodiments, the one or more bacteria in the composition are spore-forming bacteria. 
     Preferably the bacterium is of a bacterial species found in the maternal microbiome (e.g., the maternal gut microbiome), including, but not limited to, a bacterial species selected from spore-forming bacteria (such as order Clostridiales (e.g., family Lachnospiraceae, family Clostridiaceae, family Ruminococcaceae, family Dehalobacteriaceae), order Turicibacterales (e.g., family Turicibacteraceae), order Anaeroplasmatales (e.g., family Anaeroplasmataceae), order Erysipelotrichales (e.g., family Erysipelotrichaceae), and order RF39), order Lactobacillales (e.g., genus  Enterococcus ), order Clostridiales (e.g., family Clostridiaceae, family Peptostreptococcaceae, family Lachnospiraceae), order Turicibacterales (e.g., genus  Turicibacter ), order Erysipelotrichales (e.g., genus  Eubacterium ), order Enterobacteriales, order Bacteroidales (e.g., genus  Bacteroides ), phylum Firmicutes (e.g., class Clostridia, class Bacilli (e.g., order Lactobacillales, order Turicibacterales), class Erysipelotrichi, and class Gammaproteobacteria), phylum Bacteroidetes (e.g., genus  Bacteroides  (such as  B. thetraiotaomicron, B. uniformis, B. vulgatus, B. ovatus, B. fragilus )), phylum Tenericutes (e.g., class Mollicutes (e.g., order Anaeroplasmatales, order RF39)), or a combination thereof. In some embodiments, the bacterial formulation comprises a bacterium and/or a combination of bacteria described herein and a pharmaceutically acceptable carrier. 
     In certain embodiments, at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% of the bacteria in the bacterial composition are spore-forming bacteria selected from order Clostridiales (e.g., family Lachnospiraceae, family Clostridiaceae, family Ruminococcaceae, family Dehalobacteriaceae), order Turicibacterales (e.g., family Turicibacteraceae), order Anaeroplasmatales (e.g., family Anaeroplasmataceae), order Erysipelotrichales (e.g., family Erysipelotrichaceae), and order RF39, or a combination thereof, such as order Clostridiales. In certain embodiments, at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% of the bacteria in the bacterial composition are selected from order Lactobacillales (e.g., genus  Enterococcus ), order Clostridiales (e.g., family Clostridiaceae, family Peptostreptococcaceae, family Lachnospiraceae), order Turicibacterales (e.g., genus  Turicibacter ), order Erysipelotrichales (e.g., genus  Eubacterium ), order Enterobacteriales, and order Bacteroidales (e.g., genus  Bacteroides ), or a combination thereof. In certain embodiments, at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% of the bacteria in the bacterial composition are selected from phylum Firmicutes, phylum Tenericutes, phylum Bacteroidetes, or a combination thereof. 
     In certain embodiments, substantially all of the bacteria in the bacterial composition are spore-forming bacteria selected from order Clostridiales (e.g., family Lachnospiraceae, family Clostridiaceae, family Ruminococcaceae, family Dehalobacteriaceae), order Turicibacterales (e.g., family Turicibacteraceae), order Anaeroplasmatales (e.g., family Anaeroplasmataceae), order Erysipelotrichales (e.g., family Erysipelotrichaceae), and order RF39, or a combination thereof, such as order Clostridiales. In certain embodiments, substantially all of the bacteria in the bacterial composition are selected from order Lactobacillales (e.g., genus  Enterococcus ), order Clostridiales (e.g., family Clostridiaceae, family Peptostreptococcaceae, family Lachnospiraceae), order Turicibacterales (e.g., genus  Turicibacter ), order Erysipelotrichales (e.g., genus  Eubacterium ), order Enterobacteriales, and order Bacteroidales (e.g., genus  Bacteroides ), or a combination thereof. In certain embodiments, substantially all of the bacteria in the bacterial composition are phylum Firmicutes, phylum Tenericutes, or phylum Bacteroidetes, or a combination thereof. 
     In certain embodiments, the bacterial composition comprises at least 1×10 3  colony forming units (CFUs), 1×10 4  colony forming units (CFUs), 1×10 5  colony forming units (CFUs), 5×10 5  colony forming units (CFUs), 1×10 6  colony forming units (CFUs), 2×10 6  colony forming units (CFUs), 3×10 6  colony forming units (CFUs), 4×10 6  colony forming units (CFUs), 5×10 6  colony forming units (CFUs), 6×10 6  colony forming units (CFUs), 7×10 6  colony forming units (CFUs), 8×10 6  colony forming units (CFUs), 9×10 6  colony forming units (CFUs), 1×10 7  colony forming units (CFUs), 2×10 7  colony forming units (CFUs), 3×10 7  colony forming units (CFUs), 4×10 7  colony forming units (CFUs), 5×10 7  colony forming units (CFUs), 6×10 7  colony forming units (CFUs), 7×10 7  colony forming units (CFUs), 8×10 7  colony forming units (CFUs), 9×10 7  colony forming units (CFUs), 1×10 8  colony forming units (CFUs), 2×10 8  colony forming units (CFUs), 3×10 8  colony forming units (CFUs), 4×10 8  colony forming units (CFUs), 5×10 8  colony forming units (CFUs), 6×10 8  colony forming units (CFUs), 7×10 8  colony forming units (CFUs), 8×10 8  colony forming units (CFUs), 9×10 8  colony forming units (CFUs), 1×10 9  colony forming units (CFUs), 5×10 9  colony forming units (CFUs), 1×10 10  colony forming units (CFUs) 5×10 10  colony forming units (CFUs), 1×10 11  colony forming units (CFUs) 5×10 11  colony forming units (CFUs), 1×10 12  colony forming units (CFUs) 5×10 12  colony forming units (CFUs), 1×10 13  colony forming units (CFUs) spore-forming bacteria selected from order Clostridiales (e.g., family Lachnospiraceae, family Clostridiaceae, family Ruminococcaceae, family Dehalobacteriaceae), order Turicibacterales (e.g., family Turicibacteraceae), order Anaeroplasmatales (e.g., family Anaeroplasmataceae), order Erysipelotrichales (e.g., family Erysipelotrichaceae), and order RF39, or a combination thereof, such as order Clostridiales. 
     In certain embodiments, the bacterial composition comprises at least 1×10 3  colony forming units (CFUs), 1×10 4  colony forming units (CFUs), 1×10 5  colony forming units (CFUs), 5×10 5  colony forming units (CFUs), 1×10 6  colony forming units (CFUs), 2×10 6  colony forming units (CFUs), 3×10 6  colony forming units (CFUs), 4×10 6  colony forming units (CFUs), 5×10 6  colony forming units (CFUs), 6×10 6  colony forming units (CFUs), 7×10 6  colony forming units (CFUs), 8×10 6  colony forming units (CFUs), 9×10 6  colony forming units (CFUs), 1×10 7  colony forming units (CFUs), 2×10 7  colony forming units (CFUs), 3×10 7  colony forming units (CFUs), 4×10 7  colony forming units (CFUs), 5×10 7  colony forming units (CFUs), 6×10 7  colony forming units (CFUs), 7×10 7  colony forming units (CFUs), 8×10 7  colony forming units (CFUs), 9×10 7  colony forming units (CFUs), 1×10 8  colony forming units (CFUs), 2×10 8  colony forming units (CFUs), 3×10 8  colony forming units (CFUs), 4×10 8  colony forming units (CFUs), 5×10 8  colony forming units (CFUs), 6×10 8  colony forming units (CFUs), 7×10 8  colony forming units (CFUs), 8×10 8  colony forming units (CFUs), 9×10 8  colony forming units (CFUs), 1×10 9  colony forming units (CFUs), 5×10 9  colony forming units (CFUs), 1×10 10  colony forming units (CFUs) 5×10 10  colony forming units (CFUs), 1×10 11  colony forming units (CFUs) 5×10 11  colony forming units (CFUs), 1×10 12  colony forming units (CFUs) 5×10 12  colony forming units (CFUs), 1×10 13  colony forming units (CFUs) of bacteria selected from order Lactobacillales (e.g., genus  Enterococcus ), order Clostridiales (e.g., family Clostridiaceae, family Peptostreptococcaceae, family Lachnospiraceae), order Turicibacterales (e.g., genus  Turicibacter ), order Erysipelotrichales (e.g., genus  Eubacterium ), order Enterobacteriales, and order Bacteroidales (e.g., genus  Bacteroides ), or a combination thereof. 
     In certain embodiments, the bacterial composition comprises at least 1×10 3  colony forming units (CFUs), 1×10 4  colony forming units (CFUs), 1×10 5  colony forming units (CFUs), 5×10 5  colony forming units (CFUs), 1×10 6  colony forming units (CFUs), 2×10 6  colony forming units (CFUs), 3×10 6  colony forming units (CFUs), 4×10 6  colony forming units (CFUs), 5×10 6  colony forming units (CFUs), 6×10 6  colony forming units (CFUs), 7×10 6  colony forming units (CFUs), 8×10 6  colony forming units (CFUs), 9×10 6  colony forming units (CFUs), 1×10 4  colony forming units (CFUs), 2×10 7  colony forming units (CFUs), 3×10 7  colony forming units (CFUs), 4×10 7  colony forming units (CFUs), 5×10 7  colony forming units (CFUs), 6×10 7  colony forming units (CFUs), 7×10 7  colony forming units (CFUs), 8×10 7  colony forming units (CFUs), 9×10 7  colony forming units (CFUs), 1×10 8  colony forming units (CFUs), 2×10 8  colony forming units (CFUs), 3×10 8  colony forming units (CFUs), 4×10 8  colony forming units (CFUs), 5×10 8  colony forming units (CFUs), 6×10 8  colony forming units (CFUs), 7×10 8  colony forming units (CFUs), 8×10 8  colony forming units (CFUs), 9×10 8  colony forming units (CFUs), 1×10 9  colony forming units (CFUs), 5×10 9  colony forming units (CFUs), 1×10 10  colony forming units (CFUs) 5×10 10  colony forming units (CFUs), 1×10 11  colony forming units (CFUs) 5×10 11  colony forming units (CFUs), 1×10 12  colony forming units (CFUs) 5×10 12  colony forming units (CFUs), 1×10 13  colony forming units (CFUs) of phylum Firmicutes, phylum Tenericutes, or phylum Bacteroidetes, or a combination thereof. 
     The selected dosage level will depend upon a variety of factors including the subject&#39;s diet, the route of administration, the time of administration, the residence time of the particular microorganism being employed, the duration of the treatment, other drugs, compounds and/or materials used in combination with the particular composition employed, the age, sex, weight, condition, general health and prior medical history of the patient being treated, and like factors well known in the medical arts. 
     A physician or veterinarian having ordinary skill in the art can readily determine and prescribe the effective amount of the pharmaceutical composition required. For example, the physician or veterinarian could prescribe and/or administer doses of the bacteria employed in the pharmaceutical composition at levels lower than that required in order to achieve the desired therapeutic effect and gradually increase the dosage until the desired effect is achieved. 
     In some embodiments, probiotic formulations containing a bacteria selected from spore-forming bacteria (order Clostridiales (e.g., family Lachnospiraceae, family Clostridiaceae, family Ruminococcaceae, family Dehalobacteriaceae), order Turicibacterales (e.g., family Turicibacteraceae), order Anaeroplasmatales (e.g., family Anaeroplasmataceae), order Erysipelotrichales (e.g., family Erysipelotrichaceae), order RF39), order Lactobacillales (e.g., genus  Enterococcus ), order Clostridiales (e.g., family Clostridiaceae, family Peptostreptococcaceae, family Lachnospiraceae), order Turicibacterales (e.g., genus  Turicibacter ), order Erysipelotrichales (e.g., genus  Eubacterium ), order Enterobacteriales, order Bacteroidales (e.g., genus  Bacteroides ), phylum Firmicutes (e.g., class Clostridia, class Bacilli (e.g., order Lactobacillales, order Turicibacterales), class Erysipelotrichi, and class Gammaproteobacteria), phylum Bacteroidetes (e.g., genus  Bacteroides  (such as  B. thetraiotaomicron, B. uniformis, B. vulgatus, B. ovatus, B. fragilus )), and phylum Tenericutes (e.g., class Mollicutes (e.g., order Anaeroplasmatales, order RF39)), or a combination thereof are provided as encapsulated, enteric coated, or powder forms, with doses ranging up to 10 11  cfu (e.g., up to 10 10  cfu). In some embodiments, the composition comprises 5×10 11  cfu of a bacteria selected from spore-forming bacteria (order Clostridiales (e.g., family Lachnospiraceae, family Clostridiaceae, family Ruminococcaceae, family Dehalobacteriaceae), order Turicibacterales (e.g., family Turicibacteraceae), order Anaeroplasmatales (e.g., family Anaeroplasmataceae), order Erysipelotrichales (e.g., family Erysipelotrichaceae), order RF39), order Lactobacillales (e.g., genus  Enterococcus ), order Clostridiales (e.g., family Clostridiaceae, family Peptostreptococcaceae, family Lachnospiraceae), order Turicibacterales (e.g., genus  Turicibacter ), order Erysipelotrichales (e.g., genus  Eubacterium ), order Enterobacteriales, order Bacteroidales (e.g., genus  Bacteroides ), phylum Firmicutes (e.g., class Clostridia, class Bacilli (e.g., order Lactobacillales, order Turicibacterales), class Erysipelotrichi, and class Gammaproteobacteria), phylum Bacteroidetes (e.g., genus  Bacteroides  (such as  B. thetraiotaomicron, B. uniformis, B. vulgatus, B. ovatus, B. fragilus )), and phylum Tenericutes (e.g., class Mollicutes (e.g., order Anaeroplasmatales, order RF39)), or a combination thereof, and 10% (w/w) corn starch in a capsule. In some embodiments, the capsule is enteric coated, e.g., for duodenal release at pH 5.5. In some embodiments, the composition comprises a powder of freeze-dried a bacteria selected from spore-forming bacteria (order Clostridiales (e.g., family Lachnospiraceae, family Clostridiaceae, family Ruminococcaceae, family Dehalobacteriaceae), order Turicibacterales (e.g., family Turicibacteraceae), order Anaeroplasmatales (e.g., family Anaeroplasmataceae), order Erysipelotrichales (e.g., family Erysipelotrichaceae), order RF39), order Lactobacillales (e.g., genus  Enterococcus ), order Clostridiales (e.g., family Clostridiaceae, family Peptostreptococcaceae, family Lachnospiraceae), order Turicibacterales (e.g., genus  Turicibacter ), order Erysipelotrichales (e.g., genus  Eubacterium ), order Enterobacteriales, order Bacteroidales (e.g., genus  Bacteroides ), phylum Firmicutes (e.g., class Clostridia, class Bacilli (e.g., order Lactobacillales, order Turicibacterales), class Erysipelotrichi, and class Gammaproteobacteria), phylum Bacteroidetes (e.g., genus  Bacteroides  (such as  B. thetraiotaomicron, B. uniformis, B. vulgatus, B. ovatus, B. fragilus )), and phylum Tenericutes (e.g., class Mollicutes (e.g., order Anaeroplasmatales, order RF39)), or a combination thereof, which is deemed to have “Qualified Presumption of Safety” (QPS) status. In some embodiments, the composition is storage-stable at frozen or refrigerated temperature. 
     Methods for producing microbial compositions may include three main processing steps. The steps are: organism banking, organism production, and preservation. In certain embodiments, a sample that contains an abundance of a bacteria selected from spore-forming bacteria (order Clostridiales (e.g., family Lachnospiraceae, family Clostridiaceae, family Ruminococcaceae, family Dehalobacteriaceae), order Turicibacterales (e.g., family Turicibacteraceae), order Anaeroplasmatales (e.g., family Anaeroplasmataceae), order Erysipelotrichales (e.g., family Erysipelotrichaceae), order RF39), order Lactobacillales (e.g., genus  Enterococcus ), order Clostridiales (e.g., family Clostridiaceae, family Peptostreptococcaceae, family Lachnospiraceae), order Turicibacterales (e.g., genus  Turicibacter ), order Erysipelotrichales (e.g., genus  Eubacterium ), order Enterobacteriales, order Bacteroidales (e.g., genus  Bacteroides ), phylum Firmicutes (e.g., class Clostridia, class Bacilli (e.g., order Lactobacillales, order Turicibacterales), class Erysipelotrichi, and class Gammaproteobacteria), phylum Bacteroidetes (e.g., genus  Bacteroides  (such as  B. thetraiotaomicron, B. uniformis, B. vulgatus, B. ovatus, B. fragilus )), phylum Tenericutes (e.g., class Mollicutes (e.g., order Anaeroplasmatales, order RF39)), or a combination thereof, may be cultured by avoiding an isolation step. 
     For banking, a bacteria selected from spore-forming bacteria (order Clostridiales (e.g., family Lachnospiraceae, family Clostridiaceae, family Ruminococcaceae, family Dehalobacteriaceae), order Turicibacterales (e.g., family Turicibacteraceae), order Anaeroplasmatales (e.g., family Anaeroplasmataceae), order Erysipelotrichales (e.g., family Erysipelotrichaceae), order RF39), order Lactobacillales (e.g., genus  Enterococcus ), order Clostridiales (e.g., family Clostridiaceae, family Peptostreptococcaceae, family Lachnospiraceae), order Turicibacterales (e.g., genus  Turicibacter ), order Erysipelotrichales (e.g., genus  Eubacterium ), order Enterobacteriales, order Bacteroidales (e.g., genus  Bacteroides ), phylum Firmicutes (e.g., class Clostridia, class Bacilli (e.g., order Lactobacillales, order Turicibacterales), class Erysipelotrichi, and class Gammaproteobacteria), phylum Bacteroidetes (e.g., genus  Bacteroides  (such as  B. thetraiotaomicron, B. uniformis, B. vulgatus, B. ovatus, B. fragilus )), and phylum Tenericutes (e.g., class Mollicutes (e.g., order Anaeroplasmatales, order RF39)), or a combination thereof, included in the microbial composition may be (1) isolated directly from a specimen or taken from a banked stock, (2) optionally cultured on a nutrient agar or broth that supports growth to generate viable biomass, and (3) the biomass optionally preserved in multiple aliquots in long-term storage. 
     In embodiments using a culturing step, the agar or broth may contain nutrients that provide essential elements and specific factors that enable growth. An example would be a medium composed of 20 g/L glucose, 10 g/L yeast extract, 10 g/L soy peptone, 2 g/L citric acid, 1.5 g/L sodium phosphate monobasic, 100 mg/L ferric ammonium citrate, 80 mg/L magnesium sulfate, 10 mg/L hemin chloride, 2 mg/L calcium chloride, 1 mg/L menadione. Another example would be a medium composed of 10 g/L beef extract, 10 g/L peptone, 5 g/L sodium chloride, 5 g/L dextrose, 3 g/L yeast extract, 3 g/L sodium acetate, 1 g/L soluble starch, and 0.5 g/L L-cysteine HCl, at pH 6.8. A variety of microbiological media and variations are well known in the art (e.g., R. M. Atlas, Handbook of Microbiological Media (2010) CRC Press). Culture media can be added to the culture at the start, may be added during the culture, or may be intermittently/continuously flowed through the culture. The strains in the bacterial composition may be cultivated alone, as a subset of the microbial composition, or as an entire collection comprising the microbial composition. As an example, a first strain may be cultivated together with a second strain in a mixed continuous culture, at a dilution rate lower than the maximum growth rate of either cell to prevent the culture from washing out of the cultivation. 
     The inoculated culture is incubated under favorable conditions for a time sufficient to build biomass. For microbial compositions for human use this is often at 37° C. temperature, pH, and other parameter with values similar to the normal human niche. The environment may be actively controlled, passively controlled (e.g., via buffers), or allowed to drift. For example, for anaerobic bacterial compositions, an anoxic/reducing environment may be employed. This can be accomplished by addition of reducing agents such as cysteine to the broth, and/or stripping it of oxygen. As an example, a culture of a bacterial composition may be grown at 37° C., pH 7, in the medium above, pre-reduced with 1 g/L cysteine-HCl. 
     When the culture has generated sufficient biomass, it may be preserved for banking. The organisms may be placed into a chemical milieu that protects from freezing (adding ‘cryoprotectants’), drying (‘lyoprotectants’), and/or osmotic shock (‘osmoprotectants’), dispensing into multiple (optionally identical) containers to create a uniform bank, and then treating the culture for preservation. Containers are generally impermeable and have closures that assure isolation from the environment. Cryopreservation treatment is accomplished by freezing a liquid at ultra-low temperatures (e.g., at or below −80° C.). Dried preservation removes water from the culture by evaporation (in the case of spray drying or ‘cool drying’) or by sublimation (e.g., for freeze drying, spray freeze drying). Removal of water improves long-term microbial composition storage stability at temperatures elevated above cryogenic conditions. Microbial composition banking may be done by culturing and preserving the strains individually, or by mixing the strains together to create a combined bank. As an example of cryopreservation, a microbial composition culture may be harvested by centrifugation to pellet the cells from the culture medium, the supernatant decanted and replaced with fresh culture broth containing 15% glycerol. The culture can then be aliquoted into 1 mL cryotubes, sealed, and placed at −80° C. for long-term viability retention. This procedure achieves acceptable viability upon recovery from frozen storage. 
     Microbial production may be conducted using similar culture steps to banking, including medium composition and culture conditions described above. It may be conducted at larger scales of operation, especially for clinical development or commercial production. At larger scales, there may be several subcultivations of the microbial composition prior to the final cultivation. At the end of cultivation, the culture is harvested to enable further formulation into a dosage form for administration. This can involve concentration, removal of undesirable medium components, and/or introduction into a chemical milieu that preserves the microbial composition and renders it acceptable for administration via the chosen route. For example, a microbial composition may be cultivated to a concentration of 10 10  CFU/mL, then concentrated 20-fold by tangential flow microfiltration; the spent medium may be exchanged by diafiltering with a preservative medium consisting of 2% gelatin, 100 mM trehalose, and 10 mM sodium phosphate buffer. The suspension can then be freeze-dried to a powder and titrated. 
     After drying, the powder may be blended to an appropriate potency, and mixed with other cultures and/or a filler such as microcrystalline cellulose for consistency and ease of handling, and the bacterial composition formulated as provided herein. 
     In certain aspects, provided are bacterial compositions for administration in subjects. In some embodiments, the bacterial compositions are combined with additional active and/or inactive materials in order to produce a final product, which may be in single dosage unit or in a multi-dose format. 
     In some embodiments, the composition comprises at least one carbohydrate. A “carbohydrate” refers to a sugar or polymer of sugars. The terms “saccharide,” “polysaccharide,” “carbohydrate,” and “oligosaccharide” may be used interchangeably. Most carbohydrates are aldehydes or ketones with many hydroxyl groups, usually one on each carbon atom of the molecule. Carbohydrates generally have the molecular formula C n H 2n O n . A carbohydrate may be a monosaccharide, a disaccharide, trisaccharide, oligosaccharide, or polysaccharide. The most basic carbohydrate is a monosaccharide, such as glucose, sucrose, galactose, mannose, ribose, arabinose, xylose, and fructose. Disaccharides are two joined monosaccharides. Exemplary disaccharides include sucrose, maltose, cellobiose, and lactose. Typically, an oligosaccharide includes between three and six monosaccharide units (e.g., raffinose, stachyose), and polysaccharides include six or more monosaccharide units. Exemplary polysaccharides include starch, glycogen, and cellulose. Carbohydrates may contain modified saccharide units such as 2′-deoxyribose wherein a hydroxyl group is removed, 2′-fluororibose wherein a hydroxyl group is replaced with a fluorine, or N-acetylglucosamine, a nitrogen-containing form of glucose (e.g., 2′-fluororibose, deoxyribose, and hexose). Carbohydrates may exist in many different forms, for example, conformers, cyclic forms, acyclic forms, stereoisomers, tautomers, anomers, and isomers. 
     In some embodiments, the composition comprises at least one lipid. As used herein, a “lipid” includes fats, oils, triglycerides, cholesterol, phospholipids, fatty acids in any form including free fatty acids. Fats, oils and fatty acids can be saturated, unsaturated (cis or trans) or partially unsaturated (cis or trans). In some embodiments the lipid comprises at least one fatty acid selected from lauric acid (12:0), myristic acid (14:0), palmitic acid (16:0), palmitoleic acid (16:1), margaric acid (17:0), heptadecenoic acid (17:1), stearic acid (18:0), oleic acid (18:1), linoleic acid (18:2), linolenic acid (18:3), octadecatetraenoic acid (18:4), arachidic acid (20:0), eicosenoic acid (20:1), eicosadienoic acid (20:2), eicosatetraenoic acid (20:4), eicosapentaenoic acid (20:5) (EPA), docosanoic acid (22:0), docosenoic acid (22:1), docosapentaenoic acid (22:5), docosahexaenoic acid (22:6) (DHA), and tetracosanoic acid (24:0). In some embodiments the composition comprises at least one modified lipid, for example a lipid that has been modified by cooking. 
     In some embodiments, the composition comprises at least one supplemental mineral or mineral source. Examples of minerals include, without limitation: chloride, sodium, calcium, iron, chromium, copper, iodine, zinc, magnesium, manganese, molybdenum, phosphorus, potassium, and selenium. Suitable forms of any of the foregoing minerals include soluble mineral salts, slightly soluble mineral salts, insoluble mineral salts, chelated minerals, mineral complexes, non-reactive minerals such as carbonyl minerals, and reduced minerals, and combinations thereof. 
     In some embodiments, the composition comprises at least one supplemental vitamin. The at least one vitamin can be fat-soluble or water soluble vitamins. Suitable vitamins include but are not limited to vitamin C, vitamin A, vitamin E, vitamin B12, vitamin K, riboflavin, niacin, vitamin D, vitamin B6, folic acid, pyridoxine, thiamine, pantothenic acid, and biotin. Suitable forms of any of the foregoing are salts of the vitamin, derivatives of the vitamin, compounds having the same or similar activity of the vitamin, and metabolites of the vitamin. 
     In some embodiments, the composition comprises an excipient. Non-limiting examples of suitable excipients include a buffering agent, a preservative, a stabilizer, a binder, a compaction agent, a lubricant, a dispersion enhancer, a disintegration agent, a flavoring agent, a sweetener, and a coloring agent. 
     In some embodiments, the excipient is a buffering agent. Non-limiting examples of suitable buffering agents include sodium citrate, magnesium carbonate, magnesium bicarbonate, calcium carbonate, and calcium bicarbonate. 
     In some embodiments, the excipient comprises a preservative. Non-limiting examples of suitable preservatives include antioxidants, such as alpha-tocopherol and ascorbate, and antimicrobials, such as parabens, chlorobutanol, and phenol. 
     In some embodiments, the composition comprises a binder as an excipient. Non-limiting examples of suitable binders include starches, pregelatinized starches, gelatin, polyvinylpyrolidone, cellulose, methylcellulose, sodium carboxymethylcellulose, ethylcellulose, polyacrylamides, polyvinyloxoazolidone, polyvinylalcohols, C12-C18 fatty acid alcohol, polyethylene glycol, polyols, saccharides, oligosaccharides, and combinations thereof. 
     In some embodiments, the composition comprises a lubricant as an excipient. Non-limiting examples of suitable lubricants include magnesium stearate, calcium stearate, zinc stearate, hydrogenated vegetable oils, sterotex, polyoxyethylene monostearate, talc, polyethyleneglycol, sodium benzoate, sodium lauryl sulfate, magnesium lauryl sulfate, and light mineral oil. 
     In some embodiments, the composition comprises a dispersion enhancer as an excipient. Non-limiting examples of suitable dispersants include starch, alginic acid, polyvinylpyrrolidones, guar gum, kaolin, bentonite, purified wood cellulose, sodium starch glycolate, isoamorphous silicate, and microcrystalline cellulose as high HLB emulsifier surfactants. 
     In some embodiments, the compositions of the present invention are combined with a carrier (e.g., a pharmaceutically acceptable carrier) which is physiologically compatible with the gastrointestinal tissue of the subject(s) to which it is administered. Carriers can be comprised of solid-based, dry materials for formulation into tablet, capsule or powdered form; or the carrier can be comprised of liquid or gel-based materials for formulations into liquid or gel forms. The specific type of carrier, as well as the final formulation depends, in part, upon the selected route(s) of administration. The therapeutic composition of the present invention may also include a variety of carriers and/or binders. In some embodiments, the carrier is micro-crystalline cellulose (MCC) added in an amount sufficient to complete the one gram dosage total weight. Carriers can be solid-based dry materials for formulations in tablet, capsule or powdered form, and can be liquid or gel-based materials for formulations in liquid or gel forms, which forms depend, in part, upon the routes of administration. Typical carriers for dry formulations include, but are not limited to: trehalose, malto-dextrin, rice flour, microcrystalline cellulose (MCC) magnesium sterate, inositol, FOS, GOS, dextrose, sucrose, and like carriers. Suitable liquid or gel-based carriers include but are not limited to: water and physiological salt solutions; urea; alcohols and derivatives (e.g., methanol, ethanol, propanol, butanol); glycols (e.g., ethylene glycol, propylene glycol, and the like). Preferably, water-based carriers possess a neutral pH value (i.e., pH 7.0). Other carriers or agents for administering the compositions described herein are known in the art, e.g., in U.S. Pat. No. 6,461,607. 
     In some embodiments, the composition comprises a disintegrant as an excipient. In some embodiments the disintegrant is a non-effervescent disintegrant. Non-limiting examples of suitable non-effervescent disintegrants include starches such as corn starch, potato starch, pregelatinized and modified starches thereof, sweeteners, clays, such as bentonite, micro-crystalline cellulose, alginates, sodium starch glycolate, gums such as agar, guar, locust bean, karaya, pectin, and tragacanth. In some embodiments the disintegrant is an effervescent disintegrant. Non-limiting examples of suitable effervescent disintegrants include sodium bicarbonate in combination with citric acid, and sodium bicarbonate in combination with tartaric acid. 
     In some embodiments, the bacterial formulation comprises an enteric coating or micro encapsulation. In certain embodiments, the enteric coating or micro encapsulation improves targeting to a desired region of the gastrointestinal tract. For example, in certain embodiments, the bacterial composition comprises an enteric coating and/or microcapsules that dissolves at a pH associated with a particular region of the gastrointestinal tract. In some embodiments, the enteric coating and/or microcapsules dissolve at a pH of about 5.5-6.2 to release in the duodenum, at a pH value of about 7.2-7.5 to release in the ileum, and/or at a pH value of about 5.6-6.2 to release in the colon. Exemplary enteric coatings and microcapsules are described, for example, in U.S. Pat. Pub. No. 2016/0022592, which is hereby incorporated by reference in its entirety. 
     In some embodiments, the composition is a food product (e.g., a food or beverage) such as a health food or beverage, a food or beverage for infants, a food or beverage for pregnant women, athletes, senior citizens or other specified group, a functional food, a beverage, a food or beverage for specified health use, a dietary supplement, a food or beverage for patients, or an animal feed. Specific examples of the foods and beverages include various beverages such as juices, refreshing beverages, tea beverages, drink preparations, jelly beverages, and functional beverages; alcoholic beverages such as beers; carbohydrate-containing foods such as rice food products, noodles, breads, and pastas; paste products such as fish hams, sausages, paste products of seafood; retort pouch products such as curries, food dressed with a thick starchy sauces, and Chinese soups; soups; dairy products such as milk, dairy beverages, ice creams, cheeses, and yogurts; fermented products such as fermented soybean pastes, yogurts, fermented beverages, and pickles; bean products; various confectionery products, including biscuits, cookies, and the like, candies, chewing gums, gummies, cold desserts including jellies, cream caramels, and frozen desserts; instant foods such as instant soups and instant soy-bean soups; microwavable foods; and the like. Further, the examples also include health foods and beverages prepared in the forms of powders, granules, tablets, capsules, liquids, pastes, and jellies. The composition may be a fermented food product, such as, but not limited to, a fermented milk product. Non-limiting examples of fermented food products include kombucha, sauerkraut, pickles, miso, tempeh, natto, kimchi, raw cheese, and yogurt. The composition may also be a food additive, such as, but not limited to, an acidulent (e.g., vinegar). Food additives can be divided into several groups based on their effects. Non-limiting examples of food additives include acidulents (e.g., vinegar, citric acid, tartaric acid, malic acid, fumaric acid, and lactic acid), acidity regulators, anticaking agents, antifoaming agents, foaming agents, antioxidants (e.g., vitamin C), bulking agents (e.g., starch), food coloring, fortifying agents, color retention agents, emulsifiers, flavors and flavor enhancers (e.g., monosodium glutamate), flour treatment agents, glazing agents, humectants, tracer gas, preservatives, stabilizers, sweeteners, and thickeners. 
     In certain embodiments, the bacteria disclosed herein are administered in conjunction with a prebiotic to the subject. Prebiotics are carbohydrates which are generally indigestible by a host animal and are selectively fermented or metabolized by bacteria. Prebiotics may be short-chain carbohydrates (e.g., oligosaccharides) and/or simple sugars (e.g., mono- and di-saccharides) and/or mucins (heavily glycosylated proteins) that alter the composition or metabolism of a microbiome in the host. The short chain carbohydrates are also referred to as oligosaccharides, and usually contain from 2 or 3 and up to 8, 9, 10, 15 or more sugar moieties. When prebiotics are introduced to a host, the prebiotics affect the bacteria within the host and do not directly affect the host. In certain aspects, a prebiotic composition can selectively stimulate the growth and/or activity of one of a limited number of bacteria in a host. Prebiotics include oligosaccharides such as fructooligosaccharides (FOS) (including inulin), galactooligosaccharides (GOS), trans-galactooligosaccharides, xylooligosaccharides (XOS), chitooligosaccharides (COS), soy oligosaccharides (e.g., stachyose and raffinose) gentiooligosaccharides, isomaltooligosaccharides, mannooligosaccharides, maltooligosaccharides and mannanoligosaccharides. Oligosaccharides are not necessarily single components, and can be mixtures containing oligosaccharides with different degrees of oligomerization, sometimes including the parent disaccharide and the monomeric sugars. Various types of oligosaccharides are found as natural components in many common foods, including fruits, vegetables, milk, and honey. Specific examples of oligosaccharides are lactulose, lactosucrose, palatinose, glycosyl sucrose, guar gum, gum Arabic, tagalose, amylose, amylopectin, pectin, xylan, and cyclodextrins. Prebiotics may also be purified or chemically or enzymatically synthesized. 
     Pharmaceutical Compositions 
     The compositions and methods of the present invention may be utilized to treat a subject in need thereof. In certain embodiments, the subject is a mammal such as a human, or a non-human mammal. When administered to subject, such as a human, the composition or the compound is preferably administered as a pharmaceutical composition comprising, for example, a compound of the invention and a pharmaceutically acceptable carrier. Pharmaceutically acceptable carriers are well known in the art and include, for example, aqueous solutions such as water or physiologically buffered saline or other solvents or vehicles such as glycols, glycerol, oils such as olive oil, or injectable organic esters. In preferred embodiments, when such pharmaceutical compositions are for human administration, particularly for invasive routes of administration (i.e., routes, such as injection or implantation, that circumvent transport or diffusion through an epithelial barrier), the aqueous solution is pyrogen-free, or substantially pyrogen-free. The excipients can be chosen, for example, to effect delayed release of an agent or to selectively target one or more cells, tissues or organs. The pharmaceutical composition can be in dosage unit form such as tablet, capsule (including sprinkle capsule and gelatin capsule), granule, lyophile for reconstitution, powder, solution, syrup, suppository, injection or the like. The composition can also be present in a transdermal delivery system, e.g., a skin patch. The composition can also be present in a solution suitable for topical administration, such as an eye drop. 
     A pharmaceutically acceptable carrier can contain physiologically acceptable agents that act, for example, to stabilize, increase solubility or to increase the absorption of a compound such as a compound of the invention. Such physiologically acceptable agents include, for example, carbohydrates, such as glucose, sucrose or dextrans, antioxidants, such as ascorbic acid or glutathione, chelating agents, low molecular weight proteins or other stabilizers or excipients. The choice of a pharmaceutically acceptable carrier, including a physiologically acceptable agent, depends, for example, on the route of administration of the composition. The preparation or pharmaceutical composition can be a self-emulsifying drug delivery system or a self-microemulsifying drug delivery system. The pharmaceutical composition (preparation) also can be a liposome or other polymer matrix, which can have incorporated therein, for example, a compound of the invention. Liposomes, for example, which comprise phospholipids or other lipids, are nontoxic, physiologically acceptable and metabolizable carriers that are relatively simple to make and administer. 
     The phrase “pharmaceutically acceptable” is employed herein to refer to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of a subject without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio. 
     “Pharmaceutically acceptable salt” is used herein to refer to an acid addition salt or a basic addition salt which is suitable for or compatible with the treatment of patients. 
     The term “pharmaceutically acceptable acid addition salt” as used herein means any non-toxic organic or inorganic salt of the disclosed compounds. Illustrative inorganic acids which form suitable salts include hydrochloric, hydrobromic, sulfuric and phosphoric acids, as well as metal salts such as sodium monohydrogen orthophosphate and potassium hydrogen sulfate. Illustrative organic acids that form suitable salts include mono-, di-, and tricarboxylic acids such as glycolic, lactic, pyruvic, malonic, succinic, glutaric, fumaric, malic, tartaric, bitartaric, citric, ascorbic, maleic, benzoic, phenylacetic, cinnamic, salicylic, and sulfosalicylic acids, as well as sulfonic acids such as p-toluene sulfonic and methanesulfonic acids. Either the mono or di-acid salts can be formed, and such salts may exist in either a hydrated, solvated or substantially anhydrous form. In general, the acid addition salts of compounds disclosed herein are more soluble in water and various hydrophilic organic solvents, and generally demonstrate higher melting points in comparison to their free base forms. The selection of the appropriate salt will be known to one skilled in the art. Other non-pharmaceutically acceptable salts, e.g., oxalates, may be used, for example, in the isolation of compounds disclosed herein for laboratory use, or for subsequent conversion to a pharmaceutically acceptable acid addition salt. 
     The term “pharmaceutically acceptable basic addition salt” as used herein means any non-toxic organic or inorganic base addition salt of any acid compounds disclosed herein. Illustrative inorganic bases which form suitable salts include lithium, sodium, potassium, calcium, magnesium, or barium hydroxide. Illustrative organic bases which form suitable salts include aliphatic, alicyclic, or aromatic organic amines such as methylamine, trimethylamine and picoline or ammonia. The selection of the appropriate salt will be known to a person skilled in the art. 
     The phrase “pharmaceutically acceptable carrier” as used herein means a pharmaceutically acceptable material, composition or vehicle, such as a liquid or solid filler, diluent, excipient, solvent or encapsulating material. Each carrier must be “acceptable” in the sense of being compatible with the other ingredients of the formulation and not injurious to the subject. Some examples of materials which can serve as pharmaceutically acceptable carriers include: (1) sugars, such as lactose, glucose and sucrose; (2) starches, such as corn starch and potato starch; (3) cellulose, and its derivatives, such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; (4) powdered tragacanth; (5) malt; (6) gelatin; (7) talc; (8) excipients, such as cocoa butter and suppository waxes; (9) oils, such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; (10) glycols, such as propylene glycol; (11) polyols, such as glycerin, sorbitol, mannitol and polyethylene glycol; (12) esters, such as ethyl oleate and ethyl laurate; (13) agar; (14) buffering agents, such as magnesium hydroxide and aluminum hydroxide; (15) alginic acid; (16) pyrogen-free water; (17) isotonic saline; (18) Ringer&#39;s solution; (19) ethyl alcohol; (20) phosphate buffer solutions; and (21) other non-toxic compatible substances employed in pharmaceutical formulations. 
     A pharmaceutical composition (preparation) can be administered to a subject by any of a number of routes of administration including, for example, orally (for example, drenches as in aqueous or non-aqueous solutions or suspensions, tablets, capsules (including sprinkle capsules and gelatin capsules), boluses, powders, granules, pastes for application to the tongue); absorption through the oral mucosa (e.g., sublingually); anally, rectally or vaginally (for example, as a pessary, cream or foam); parenterally (including intramuscularly, intravenously, subcutaneously or intrathecally as, for example, a sterile solution or suspension); nasally; intraperitoneally; subcutaneously; transdermally (for example as a patch applied to the skin); and topically (for example, as a cream, ointment or spray applied to the skin, or as an eye drop). The compound may also be formulated for inhalation. In certain embodiments, a compound may be simply dissolved or suspended in sterile water. Details of appropriate routes of administration and compositions suitable for same can be found in, for example, U.S. Pat. Nos. 6,110,973, 5,763,493, 5,731,000, 5,541,231, 5,427,798, 5,358,970 and 4,172,896, as well as in patents cited therein. 
     The formulations may conveniently be presented in unit dosage form and may be prepared by any methods well known in the art of pharmacy. The amount of active ingredient which can be combined with a carrier material to produce a single dosage form will vary depending upon the subject being treated, the particular mode of administration. The amount of active ingredient that can be combined with a carrier material to produce a single dosage form will generally be that amount of the compound which produces a therapeutic effect. Generally, out of one hundred percent, this amount will range from about 1 percent to about ninety-nine percent of active ingredient, preferably from about 5 percent to about 70 percent, most preferably from about 10 percent to about 30 percent. 
     Methods of preparing these formulations or compositions include the step of bringing into association an active compound, such as a compound of the invention, with the carrier and, optionally, one or more accessory ingredients. In general, the formulations are prepared by uniformly and intimately bringing into association a compound of the present invention with liquid carriers, or finely divided solid carriers, or both, and then, if necessary, shaping the product. 
     Formulations of the invention suitable for oral administration may be in the form of capsules (including sprinkle capsules and gelatin capsules), cachets, pills, tablets, lozenges (using a flavored basis, usually sucrose and acacia or tragacanth), lyophile, powders, granules, or as a solution or a suspension in an aqueous or non-aqueous liquid, or as an oil-in-water or water-in-oil liquid emulsion, or as an elixir or syrup, or as pastilles (using an inert base, such as gelatin and glycerin, or sucrose and acacia) and/or as mouth washes and the like, each containing a predetermined amount of a compound of the present invention as an active ingredient. Compositions or compounds may also be administered as a bolus, electuary or paste. 
     To prepare solid dosage forms for oral administration (capsules (including sprinkle capsules and gelatin capsules), tablets, pills, dragees, powders, granules and the like), the active ingredient is mixed with one or more pharmaceutically acceptable carriers, such as sodium citrate or dicalcium phosphate, and/or any of the following: (1) fillers or extenders, such as starches, lactose, sucrose, glucose, mannitol, and/or silicic acid; (2) binders, such as, for example, carboxymethylcellulose, alginates, gelatin, polyvinyl pyrrolidone, sucrose and/or acacia; (3) humectants, such as glycerol; (4) disintegrating agents, such as agar-agar, calcium carbonate, potato or tapioca starch, alginic acid, certain silicates, and sodium carbonate; (5) solution retarding agents, such as paraffin; (6) absorption accelerators, such as quaternary ammonium compounds; (7) wetting agents, such as, for example, cetyl alcohol and glycerol monostearate; (8) absorbents, such as kaolin and bentonite clay; (9) lubricants, such a talc, calcium stearate, magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate, and mixtures thereof; (10) complexing agents, such as, modified and unmodified cyclodextrins; and (11) coloring agents. In the case of capsules (including sprinkle capsules and gelatin capsules), tablets and pills, the pharmaceutical compositions may also comprise buffering agents. Solid compositions of a similar type may also be employed as fillers in soft and hard-filled gelatin capsules using such excipients as lactose or milk sugars, as well as high molecular weight polyethylene glycols and the like. 
     A tablet may be made by compression or molding, optionally with one or more accessory ingredients. Compressed tablets may be prepared using binder (for example, gelatin or hydroxypropylmethyl cellulose), lubricant, inert diluent, preservative, disintegrant (for example, sodium starch glycolate or cross-linked sodium carboxymethyl cellulose), surface-active or dispersing agent. Molded tablets may be made by molding in a suitable machine a mixture of the powdered compound moistened with an inert liquid diluent. 
     The tablets, and other solid dosage forms of the pharmaceutical compositions, such as dragees, capsules (including sprinkle capsules and gelatin capsules), pills and granules, may optionally be scored or prepared with coatings and shells, such as enteric coatings and other coatings well known in the pharmaceutical-formulating art. They may also be formulated so as to provide slow or controlled release of the active ingredient therein using, for example, hydroxypropylmethyl cellulose in varying proportions to provide the desired release profile, other polymer matrices, liposomes and/or microspheres. They may be sterilized by, for example, filtration through a bacteria-retaining filter, or by incorporating sterilizing agents in the form of sterile solid compositions that can be dissolved in sterile water, or some other sterile injectable medium immediately before use. These compositions may also optionally contain opacifying agents and may be of a composition that they release the active ingredient(s) only, or preferentially, in a certain portion of the gastrointestinal tract, optionally, in a delayed manner. Examples of embedding compositions that can be used include polymeric substances and waxes. The active ingredient can also be in micro-encapsulated form, if appropriate, with one or more of the above-described excipients. 
     Liquid dosage forms useful for oral administration include pharmaceutically acceptable emulsions, lyophiles for reconstitution, microemulsions, solutions, suspensions, syrups and elixirs. In addition to the active ingredient, the liquid dosage forms may contain inert diluents commonly used in the art, such as, for example, water or other solvents, cyclodextrins and derivatives thereof, solubilizing agents and emulsifiers, such as ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylene glycol, oils (in particular, cottonseed, groundnut, corn, germ, olive, castor and sesame oils), glycerol, tetrahydrofuryl alcohol, polyethylene glycols and fatty acid esters of sorbitan, and mixtures thereof. 
     Besides inert diluents, the oral compositions can also include adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring, coloring, perfuming and preservative agents. 
     Suspensions, in addition to the active compounds, may contain suspending agents as, for example, ethoxylated isostearyl alcohols, polyoxyethylene sorbitol and sorbitan esters, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar-agar and tragacanth, and mixtures thereof. 
     Formulations of the pharmaceutical compositions for rectal, vaginal, or urethral administration may be presented as a suppository, which may be prepared by mixing one or more active compounds with one or more suitable nonirritating excipients or carriers comprising, for example, cocoa butter, polyethylene glycol, a suppository wax or a salicylate, and which is solid at room temperature, but liquid at body temperature and, therefore, will melt in the rectum or vaginal cavity and release the active compound. 
     Formulations of the pharmaceutical compositions for administration to the mouth may be presented as a mouthwash, or an oral spray, or an oral ointment. 
     Alternatively or additionally, compositions can be formulated for delivery via a catheter, stent, wire, or other intraluminal device. Delivery via such devices may be especially useful for delivery to the bladder, urethra, ureter, rectum, or intestine. 
     Formulations which are suitable for vaginal administration also include pessaries, tampons, creams, gels, pastes, foams or spray formulations containing such carriers as are known in the art to be appropriate. 
     Dosage forms for the topical or transdermal administration include powders, sprays, ointments, pastes, creams, lotions, gels, solutions, patches and inhalants. The active compound may be mixed under sterile conditions with a pharmaceutically acceptable carrier, and with any preservatives, buffers, or propellants that may be required. 
     The ointments, pastes, creams and gels may contain, in addition to an active compound, excipients, such as animal and vegetable fats, oils, waxes, paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicic acid, talc and zinc oxide, or mixtures thereof. 
     Powders and sprays can contain, in addition to an active compound, excipients such as lactose, talc, silicic acid, aluminum hydroxide, calcium silicates and polyamide powder, or mixtures of these substances. Sprays can additionally contain customary propellants, such as chlorofluorohydrocarbons and volatile unsubstituted hydrocarbons, such as butane and propane. 
     Transdermal patches have the added advantage of providing controlled delivery of a compound of the present invention to the body. Such dosage forms can be made by dissolving or dispersing the active compound in the proper medium. Absorption enhancers can also be used to increase the flux of the compound across the skin. The rate of such flux can be controlled by either providing a rate controlling membrane or dispersing the compound in a polymer matrix or gel. 
     Ophthalmic formulations, eye ointments, powders, solutions and the like, are also contemplated as being within the scope of this invention. Exemplary ophthalmic formulations are described in U.S. Publication Nos. 2005/0080056, 2005/0059744, 2005/0031697 and 2005/004074 and U.S. Pat. No. 6,583,124, the contents of which are incorporated herein by reference. If desired, liquid ophthalmic formulations have properties similar to that of lacrimal fluids, aqueous humor or vitreous humor or are compatible with such fluids. A preferred route of administration is local administration (e.g., topical administration, such as eye drops, or administration via an implant). 
     The phrases “parenteral administration” and “administered parenterally” as used herein means modes of administration other than enteral and topical administration, usually by injection, and includes, without limitation, intravenous, intramuscular, intraarterial, intrathecal, intracapsular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subcuticular, intraarticular, intraocular, subcapsular, subarachnoid, intraspinal and intrasternal injection and infusion. 
     Pharmaceutical compositions suitable for parenteral administration comprise one or more active compounds in combination with one or more pharmaceutically acceptable sterile isotonic aqueous or nonaqueous solutions, dispersions, suspensions or emulsions, or sterile powders which may be reconstituted into sterile injectable solutions or dispersions just prior to use, which may contain antioxidants, buffers, bacteriostats, solutes which render the formulation isotonic with the blood of the intended recipient or suspending or thickening agents. 
     Examples of suitable aqueous and nonaqueous carriers that may be employed in the pharmaceutical compositions of the invention include water, ethanol, polyols (such as glycerol, propylene glycol, polyethylene glycol, and the like), and suitable mixtures thereof, vegetable oils, such as olive oil, and injectable organic esters, such as ethyl oleate. Proper fluidity can be maintained, for example, by the use of coating materials, such as lecithin, by the maintenance of the required particle size in the case of dispersions, and by the use of surfactants. 
     These compositions may also contain adjuvants such as preservatives, wetting agents, emulsifying agents and dispersing agents. Prevention of the action of microorganisms may be ensured by the inclusion of various antibacterial and antifungal agents, for example, paraben, chlorobutanol, phenol sorbic acid, and the like. It may also be desirable to include isotonic agents, such as sugars, sodium chloride, and the like into the compositions. In addition, prolonged absorption of the injectable pharmaceutical form may be brought about by the inclusion of agents that delay absorption such as aluminum monostearate and gelatin. 
     In some cases, in order to prolong the effect of a drug, it is desirable to slow the absorption of the drug from subcutaneous or intramuscular injection. This may be accomplished by the use of a liquid suspension of crystalline or amorphous material having poor water solubility. The rate of absorption of the drug then depends upon its rate of dissolution, which, in turn, may depend upon crystal size and crystalline form. Alternatively, delayed absorption of a parenterally administered drug form is accomplished by dissolving or suspending the drug in an oil vehicle. 
     Injectable depot forms are made by forming microencapsulated matrices of the subject compounds in biodegradable polymers such as polylactide-polyglycolide. Depending on the ratio of drug to polymer, and the nature of the particular polymer employed, the rate of drug release can be controlled. Examples of other biodegradable polymers include poly(orthoesters) and poly(anhydrides). Depot injectable formulations are also prepared by entrapping the drug in liposomes or microemulsions that are compatible with body tissue. 
     For use in the methods of this invention, active compounds can be given per se or as a pharmaceutical composition containing, for example, about 0.1 to about 99.5% (more preferably, about 0.5 to about 90%) of active ingredient in combination with a pharmaceutically acceptable carrier. 
     Methods of introduction may also be provided by rechargeable or biodegradable devices. Various slow release polymeric devices have been developed and tested in vivo in recent years for the controlled delivery of drugs, including proteinacious biopharmaceuticals. A variety of biocompatible polymers (including hydrogels), including both biodegradable and non-degradable polymers, can be used to form an implant for the sustained release of a compound at a particular target site. 
     Actual dosage levels of the active ingredients in the pharmaceutical compositions may be varied so as to obtain an amount of the active ingredient that is effective to achieve the desired therapeutic response for a particular patient, composition, and mode of administration, without being toxic to the patient. 
     The selected dosage level will depend upon a variety of factors including the activity of the particular compound or combination of compounds employed, or the ester, salt or amide thereof, the route of administration, the time of administration, the rate of excretion of the particular compound(s) being employed, the duration of the treatment, other drugs, compounds and/or materials used in combination with the particular compound(s) employed, the age, sex, weight, condition, general health and prior medical history of the subject being treated, and like factors well known in the medical arts. 
     A physician or veterinarian having ordinary skill in the art can readily determine and prescribe the therapeutically effective amount of the pharmaceutical composition required. For example, the physician or veterinarian could start doses of the pharmaceutical composition or compound at levels lower than that required in order to achieve the desired therapeutic effect and gradually increase the dosage until the desired effect is achieved. By “therapeutically effective amount” is meant the concentration of a compound that is sufficient to elicit the desired therapeutic effect. It is generally understood that the effective amount of the compound will vary according to the weight, sex, age, and medical history of the subject. Other factors which influence the effective amount may include, but are not limited to, the severity of the subject&#39;s condition, the disorder being treated, the stability of the compound, and, if desired, another type of therapeutic agent being administered with the compound of the invention. A larger total dose can be delivered by multiple administrations of the agent. Methods to determine efficacy and dosage are known to those skilled in the art (Isselbacher et al. (1996) Harrison&#39;s Principles of Internal Medicine 13 ed., 1814-1882, herein incorporated by reference). 
     In general, a suitable daily dose of an active compound used in the compositions and methods of the invention will be that amount of the compound that is the lowest dose effective to produce a therapeutic effect. Such an effective dose will generally depend upon the factors described above. 
     If desired, the effective daily dose of the active compound may be administered as one, two, three, four, five, six or more sub-doses administered separately at appropriate intervals throughout the day, optionally, in unit dosage forms. In certain embodiments of the present invention, the active compound may be administered two or three times daily. In preferred embodiments, the active compound will be administered once daily. 
     In certain embodiments, compounds of the invention may be used alone or conjointly administered with another type of therapeutic agent. 
     In certain embodiments, conjoint administration of compounds of the invention with one or more additional therapeutic agent(s) provides improved efficacy relative to each individual administration of the compound of the invention or the one or more additional therapeutic agent(s). In certain such embodiments, the conjoint administration provides an additive effect, wherein an additive effect refers to the sum of each of the effects of individual administration of the compound of the invention and the one or more additional therapeutic agent(s). 
     This invention includes the use of pharmaceutically acceptable salts of compounds of the invention in the compositions and methods of the present invention. In certain embodiments, contemplated salts of the invention include, but are not limited to, alkyl, dialkyl, trialkyl or tetra-alkyl ammonium salts. In certain embodiments, contemplated salts of the invention include, but are not limited to, L-arginine, benenthamine, benzathine, betaine, calcium hydroxide, choline, deanol, diethanolamine, diethylamine, 2-(diethylamino)ethanol, ethanolamine, ethylenediamine, N-methylglucamine, hydrabamine, 1H-imidazole, lithium, L-lysine, magnesium, 4-(2-hydroxyethyl)morpholine, piperazine, potassium, 1-(2-hydroxyethyl)pyrrolidine, sodium, triethanolamine, tromethamine, and zinc salts. In certain embodiments, contemplated salts of the invention include, but are not limited to, Na, Ca, K, Mg, Zn or other metal salts. 
     The pharmaceutically acceptable acid addition salts can also exist as various solvates, such as with water, methanol, ethanol, dimethylformamide, and the like. Mixtures of such solvates can also be prepared. The source of such solvate can be from the solvent of crystallization, inherent in the solvent of preparation or crystallization, or adventitious to such solvent. 
     Wetting agents, emulsifiers and lubricants, such as sodium lauryl sulfate and magnesium stearate, as well as coloring agents, release agents, coating agents, sweetening, flavoring and perfuming agents, preservatives and antioxidants can also be present in the compositions. 
     Examples of pharmaceutically acceptable antioxidants include: (1) water-soluble antioxidants, such as ascorbic acid, cysteine hydrochloride, sodium bisulfate, sodium metabisulfite, sodium sulfite and the like; (2) oil-soluble antioxidants, such as ascorbyl palmitate, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), lecithin, propyl gallate, alpha-tocopherol, and the like; and (3) metal-chelating agents, such as citric acid, ethylenediamine tetraacetic acid (EDTA), sorbitol, tartaric acid, phosphoric acid, and the like. 
     EXAMPLES 
     Example 1: The Maternal Microbiome Modulates Fetal Neurodevelopment and Offspring Sensory Behaviour 
     Summary 
     “Dysbiosis” of the maternal gut microbiome, in response to environmental challenges such as infection, altered diet and stress during pregnancy, has been increasingly associated with abnormalities in offspring brain function and behavior. However, whether the maternal gut microbiome regulates neurodevelopment in the absence of environmental challenge remains unclear. In addition, whether the maternal microbiome exerts such influences during critical periods of embryonic brain development is poorly understood. Here we investigate how depletion, and selective colonization, of the maternal gut microbiota influences fetal neurodevelopment. Embryos from antibiotic-treated and germ-free dams exhibit widespread transcriptomic alterations in the fetal brain relative to conventionally-colonized controls, with reduced expression of several genes involved in axonogenesis. In addition, embryos from microbiome-depleted mothers exhibit deficient thalamocortical axons and impaired thalamic axon outgrowth in response to cell-extrinsic guidance cues and growth factors. Consistent with the importance of fetal thalamocortical axonogenesis for shaping sensory processing neural circuits, restricted depletion of the maternal microbiome from pre-conception through mid-gestation yields offspring that exhibit tactile hyposensitivity in sensorimotor behavioral tasks. Gnotobiotic colonization of antibiotic-treated dams with a limited consortium of bacteria indigenous to the gut microbiome prevents abnormalities in fetal brain gene expression, fetal thalamocortical axonogenesis and adult tactile sensory behavior associated with maternal microbiome depletion. Metabolomic profiling reveals that the maternal microbiome regulates levels of numerous small molecules in the maternal serum as well as the brains of fetal offspring. Select microbiome-dependent metabolites—trimethylamine N-oxide, 5-aminovalerate, imidazole propionate, and hippurate—sufficiently promote axon outgrowth from fetal thalamic explants. Moreover, maternal supplementation with the metabolites during early gestation abrogates deficiencies in fetal thalamocortical axons and prevents abnormalities in tactile sensory behavior in offspring from microbiome-depleted dams. Altogether, these findings reveal that the maternal gut microbiome promotes fetal thalamocortical axonogenesis and offspring sensory behavior, likely by direct signaling of microbially modulated metabolites to neurons in the developing brain. 
     Results and Discussion 
     The intestinal microbiome is an important modulator of brain function and behavior 1 . However, whether the maternal gut microbiome impacts the brain development during prenatal critical periods is poorly understood. Various model organisms reared devoid of microbial colonization (germ-free, GF) or depleted of the gut microbiome (antibiotic-treated, ABX) exhibit altered neurophysiology and behavior compared to conventionally-colonized (specific pathogen-free, SPF) controls 2-4 . Interestingly, only a subset of phenotypes can be corrected by postnatal restoration of the microbiome 5-8 , suggesting a role for the early life microbiome in regulating developmental processes that impact brain function and behavior in adulthood. Indeed, in animal models, the gut microbiome is required for mediating adverse effects of maternal challenges, such as immune activation 9,10 , high fat diet 6  and psychosocial stress 11,12 , on neurobehavioral abnormalities in adult offspring. It remains unclear, however, whether such microbial influences on neurodevelopment originate antenatally, via disrupted function of the maternal microbiome, and/or postnatally, via vertically transmitted alterations in the neonatal microbiome 13-15 . Moreover, while existing studies report that the maternal gut microbiome can modulate host responses to acute dietary-, stress- or inflammation-related insults, whether it impacts offspring development in the absence of environmental challenges requires investigation. Herein, we examine roles for the maternal gut microbiome during homeostasis in regulating early embryonic brain development and later-life behavior of the offspring. 
     To determine whether the maternal microbiome influences fetal neurodevelopment, we first examined fetal brains from offspring of murine dams that were reared SPF, GF, or treated with broad-spectrum ABX to deplete the maternal gut microbiome from pre-conception through midgestation [embryonic day (E)14.5]. Transcriptomic profiling revealed that depletion of the maternal microbiome altered the expression of 333 genes in fetal brains of E14.5 embryos, including many involved in axonogenesis ( FIG. 1A , Table 1). Gene ontology analysis indicated that these genes were relevant for cell proliferation, cell junction, cell-matrix adhesion and cellular developmental processes ( FIG. 2A ). The 160 downregulated genes mapped to protein interaction networks that included those relevant to axon guidance, Wnt signaling, cell morphogenesis, neuronal differentiation and glutamatergic synapse ( FIG. 2C ), whereas the 173 upregulated genes mapped to networks that included those relevant to apoptosis, long-term depression, cell adhesion and GABAergic synapse ( FIG. 2D ). Validation by qPCR revealed consistent downregulation of Netrin-G1 a (NTNG1), a glycosylphosphatidylinositol-tethered protein highly expressed by developing thalamocortical axons 16 , in fetal brains from offspring of both ABX and GF dams ( FIG. 2B ). Consistent with observed reductions in NTNG1 transcript ( FIG. 1A ,  FIG. 2C ), fetal brain sections from E14.5 offspring of both ABX and GF dams exhibited reduced Netrin-G1a+immunoreactivity localized to thalamocortical neurons ( FIGS. 1B-1C ,  FIGS. 3A-3I ). In addition, evaluation of three-dimensional representations of Netrin-G1a+thalamocortical axons in cleared whole embryonic brains revealed decreased axonal volume and length in E14.5 offspring from microbiome-depleted dams, with corresponding increases in distances from the leading axon to the cortex and reduced circumference of the axonal bundle at the internal capsule ( FIGS. 1E-1I ). Notably, fetal brains from ABX offspring displayed decreased L1+ axonal immunoreactivity compared to SPF control, but no significant differences in neuronal DAPI levels in the thalamus ( FIG. 1D ,  FIGS. 31 and 4A-4E ). This suggests that the reductions in Netrin-G1a expression reflect decreases in thalamocortical axonal projections, rather than diminished receptor expression on existing axons or the absence of thalamic neurons themselves. 
     These findings align with recent studies reporting reductions in adult axonal markers in the cortex and myenteric plexus in response to microbiota depletion 17-20  (Example 3). Overall, results from these experiments suggest that the maternal microbiome is required to support fetal thalamocortical axonogenesis in the developing offspring. 
     Axonogenesis involves cell intrinsic and extrinsic factors that work in concert to direct axon polarity, elongation and pathfinding. To gain insight into whether the reductions in Netrin-G1a+thalamocortical axons seen in response to maternal microbiome depletion were due to impaired axon formation, deficient axon guidance, or both, we cultured E14.5 thalamic explants, either alone or in the presence of endogenous cues from striatal and hypothalamic explants 21,22 . Monoculture of E14.5 thalamic explants from offspring of either SPF or ABX dams resulted in substantial axon outgrowth ( FIGS. 5A-5C ), suggesting that the reductions in Netrin-Ole axons seen in embryos of microbiome-depleted dams are not due to an intrinsic inability of the thalamus to form or elongate axons. Indeed, thalamic neurons from embryos of ABX dams generated increased numbers of axons when grown in cell culture matrices containing growth factors, with no significant difference in axon length, as compared to SPF controls ( FIGS. 5A-5C ); this suggests enhanced capacity for axon formation, but not elongation, in fetal thalamic neurons from ABX dams that are grown in rich media. However, in response to co-culture with fetal striatal and hypothalamic explants from ABX dams, fetal thalamic neurons from embryos of ABX dams exhibited impaired axon outgrowth, with decreased number and length of axons as compared to co-cultured control explants from SPF mothers ( FIGS. 1J-1M , white vs. black). These abnormalities in cue-mediated axonal outgrowth were observed for thalamic axons proximal to the striatal explant ( FIGS. 1J-1M , white vs. black), which produces growth promoting and attractive guidance cues 23,24 , as well as axons proximal to the hypothalamic explant ( FIGS. 5D-5F , white vs. black), which produces growth-inhibiting and repulsive guidance cues 25,26 . Taken together, these results indicate that fetal thalamic neurons from E14.5 offspring of ABX dams display deficient axon outgrowth in response to cell-extrinsic tissue-derived factors. 
     To gain further insight into whether depletion of the maternal microbiome alters tissue-derived cues to impair axon outgrowth, fetal thalamic explants from E14.5 embryos of SPF or ABX dams were co-cultured with striatal and hypothalamic explants from the contrasting experimental group. When thalamic explants from E14.5 embryos of SPF dams were co-cultured with fetal striatal and hypothalamic explants from offspring of ABX dams, there were no significant differences in the number or length of axons from SPF thalamic neurons proximal to the ABX striatal ( FIGS. 1J-1M ; purple in the original image vs. black) or hypothalamic explants ( FIGS. 5D-5F ; purple in the original image vs. black). This suggests that tissue-derived factors from ABX dams sufficiently support axon outgrowth from SPF thalamic neurons. In contrast, when thalamic explants from E14.5 embryos of ABX dams were co-cultured with fetal striatal and hypothalamic explants from offspring of SPF dams, fetal thalamic neurons from ABX offspring exhibited deficiencies in axon outgrowth, at levels similar to those seen in response to co-culture with ABX tissues ( FIGS. 1J-1M ,  FIGS. 5D-5F ; teal in the original image vs. white). This suggests that endogenous soluble factors from SPF explants are not sufficient to correct impairments in axon outgrowth of ABX thalamic neurons, and that ABX thalamic neurons display incorrect responses to factors from SPF tissues. Such impairments in axon outgrowth in response to tissue-derived cues could be attributed to erroneously repulsive responses to attractive guidance cues 27,28 , hyperresponsiveness to repulsive cues 29  and/or cue-induced disruptions in responses to neurotrophic factors present in the culture media 30 . Overall, these findings indicate that tissue-derived cues are necessary but not sufficient for mediating maternal microbiota-dependent reductions in thalamic axonogenesis and further suggest that depletion of the maternal microbiome impairs responses of embryonic thalamocortical neurons to axonogenic cues. 
     From prenatal through early postnatal development, thalamocortical axons are guided to the somatosensory cortex, where they form dense synaptic contacts with layer 4 neurons to mediate sensory processing 31-34 . To gain insight into whether microbiome-induced alterations in fetal thalamocortical axonogenesis confer lasting influences on offspring behavior, SPF dams were treated with ABX or vehicle from pre-conception through E14.5, and then colonized with a conventional SPF microbiome for the remainder of gestation through offspring postnatal development ( FIG. 6A ). Conventionalized offspring of ABX- or vehicle-treated dams were tested in a battery of sensory behavioral tasks ( FIGS. 6A-6G ,  FIGS. 7A-7F and 8A-8F ). In the von Frey filament test for hindpaw sensorimotor function 35,36 , adult offspring of ABX dams required significantly increased force thresholds for paw withdrawal in response to hindpaw stimulation compared to control offspring from SPF dams ( FIGS. 6B-6C ), suggesting impaired tactile sensation. Consistent with this, in the adhesive removal test for forepaw sensorimotor function 37 , adult offspring of ABX dams exhibited significantly increased latency to detect and contact the forepaw stimulus compared to control offspring from SPF dams ( FIGS. 6D-6E ). There was no difference in the time taken to remove the adhesive after first contact ( FIG. 6F ), suggesting that ABX offspring exhibit deficient initial paw tactile sensation, but no disruption in motor response ( FIG. 6G ). Statistically significant effects of the maternal microbiome on offspring tactile sensory behavior were observed when data were averaged by litter to represent individual dams as biological replicates ( FIGS. 6A-6G ), as well as when data from individual offspring were analyzed ( FIGS. 7A-7C ). There was no statistically significant difference in behavioral performance between male and female mice in these tasks ( FIGS. 7D-7F ). In addition, abnormalities in sensory behavior appeared to be limited to paw tactile responses, as there were no differences in behavioral performance between ABX and control SPF offspring in the hot plate test for thermosensory behavior 38 , the visual cliff test for visual sensory behavior 39 , the whisker-dependent texture discrimination test for vibrissae sensory perception 40 , the rotarod test for motor coordination 41  and the prepulse inhibition task for acoustic startle response and sensorimotor gating 42  ( FIG. 8A-8F ). Altogether, these results demonstrate that depletion of the maternal gut microbiome during early to mid-gestation impairs fetal thalamocortical axonogenesis and yields adult offspring with disrupted neurobehavioral responses to forepaw and hindpaw tactile stimuli. 
     The gut microbiome is comprised of several hundred different bacterial taxa, many of which exhibit specialized functions and differential interactions with host physiology” 43-46 . To determine whether the effects of the maternal microbiome on offspring neurodevelopment and behavior are mediated by particular bacterial taxa, we colonized ABX-treated dams during preconception with a consortium of bacteria representing one of the two dominant phyla of the gut microbiota—Firmicutes and Bacteroidetes ( FIGS. 9A-10B and 11A , Tables 2 and 3). Colonization of ABX-treated dams with Clostridia-dominant spore-forming bacteria (Sp) of the phylum Firmicutes abrogated many adverse effects of maternal microbiota depletion on fetal brain gene expression and thalamocortical axon outgrowth ( FIGS. 10A-10M ). E14.5 fetal brains from embryos of Sp-colonized dams exhibited transcriptomic profiles that clustered closely with samples derived from SPF controls, with restored expression of many genes relevant to axon guidance ( FIG. 10A ;  FIGS. 9C-9F , Table 1). Notably, reductions in NTNG1 expression and Netrin-G1a+thalamocortical axons observed in response to maternal microbiome depletion were prevented by maternal colonization with Sp bacteria ( FIGS. 10B-10J ,  FIGS. 3A-3I and 4A-4E ,  FIGS. 9C-9F ). In contrast, colonizing ABX-treated dams with a consortium of  Bacteroides  (BD), containing  B. thetaiotaomicron, B. uniformis, B. vulgatus, B. ovatus  and  B. fragilis  ( FIG. 11A ), conferred only a modest increase in Netrin-G1a+thalamocortical axons in fetal brains from E14.5 offspring, which exhibited statistical significance by group, but not across individual rostral to caudal sections compared to ABX controls ( FIGS. 11B-11D ). Fetal thalamic explants from E14.5 embryos of Sp-colonized dams also exhibited significantly increased axon outgrowth compared to controls from ABX-treated dams ( FIGS. 5G-5L ). Deficiencies in paw tactile sensory behavior in the adhesive removal and von Frey filament tests seen in adult offspring of ABX-treated dams were also prevented by maternal colonization with Sp bacteria ( FIGS. 10K-10M ), with no differences in performance between males and females and in other sensory behavioral tasks ( FIGS. 7A-7F and 8A-8F ). Overall, these findings suggest that limited bacterial taxa, including Sp bacteria in particular, are sufficient to prevent the adverse effects of maternal microbiota depletion on fetal thalamocortical axonogenesis and offspring sensory behavior. 
     The gut microbiome modulates the bioavailability of hundreds of biochemicals in the circulating blood 8,47-49 . During pregnancy, the maternal intrauterine environment supplies nutrients and growth factors to nurture offspring growth, which is particularly important for the rapidly developing fetal brain 50,51 . The blood brain barrier begins forming at E16.5 and continues developing during the first three weeks of postnatal life 52,53 , rendering the developing fetal brain permeable to circulating metabolites. Based on our finding that the maternal microbiota is important for regulating fetal neurodevelopment, we hypothesized that the maternal microbiome regulates maternal circulating metabolites and thereby conditions metabolite profiles in the fetus. To investigate this, we performed tandem liquid chromatography mass spectrometry to globally profile biochemicals in maternal sera and fetal brain lysates from SPF, ABX, GF and Sp-colonized dams on E14.5 of gestation. A total of 753 metabolites were identified in maternal sera and 567 in fetal brain lysates, spanning amino acid, carbohydrate, co-factor and vitamin, energy, lipid, nucleotide, peptide and xenobiotic biochemical super pathways (Tables 4 and 5). Supervised hierarchical clustering of samples based on differential levels of maternal blood metabolites led to co-clustering of samples derived from SPF and Sp dams compared to GF and ABX dams ( FIG. 12A ). Metabolomic profiles in maternal blood from ABX and GF mice clustered closely by principal component analysis (PCA), whereas those from SPF and Sp-colonized dams formed a separate co-cluster ( FIG. 12B ). This suggests that Sp bacteria recapitulate many of the effects of the SPF microbiota on maternal blood biochemical profiles, and further aligns with the phenotypic similarities between offspring of ABX and GF dams versus SPF and Sp dams in fetal axonogenesis and adult sensory behavior. Random Forests analysis identified 30 maternal blood metabolites that discriminate maternal microbiota status with 100% predictive accuracy ( FIG. 13A ). Overall, these data reveal widespread effects of the maternal microbiome on circulating serum biochemicals during pregnancy. 
     Interestingly, metabolomic profiles from fetal brain lysates of SPF dams clustered away from profiles from fetal brain lysates of Sp-colonized, ABX, and GF dams ( FIG. 12C ), suggesting that there are global alterations in fetal brain metabolomic profiles from E14.5 fetal brains of offspring from gnotobiotic mothers. 165 fetal brain metabolites were commonly downregulated in embryos from ABX and GF dams, relative to SPF controls ( FIG. 12D , Table 4). 27 fetal brain metabolites were commonly downregulated in embryos from ABX and GF dams, relative to Sp controls ( FIG. 12E , Table 4). Pathway analysis revealed alterations in several amino acid, lipid, and xenobiotic metabolites in fetal brain lysates from ABX and GF dams compared to SPF and Sp dams ( FIGS. 12F-12G ,  FIG. 13C ). Random Forests analysis identified the top 30 fetal brain metabolites that were predictive with 87.5% accuracy of maternal SPF and Sp versus ABX and GF microbiota status ( FIG. 12H ). 22 metabolites were similarly and significantly decreased in fetal brain lysates from ABX and GF dams relative to both SPF and Sp dams (Table 5). Of these 22 fetal brain metabolites, 8 were similarly differentially regulated in maternal sera from ABX and GF dams compared to SPF and Sp controls (Table 5), suggesting that the maternal microbiome modulates the bioavailability of these metabolites in maternal blood with direct effects on the bioavailability of the same metabolites in fetal brain. Overall, these findings reveal that the maternal microbiome modulates biochemical profiles and select metabolites in the fetal brains of developing offspring. 
     To further determine whether particular microbiota-dependent metabolites in the fetal brain mediate the ability of the maternal microbiome to promote fetal thalamocortical axonogenesis, thalamic explants from E14.5 embryos of ABX-treated dams were exposed to physiologically-relevant levels of select fetal brain biochemicals, and axon outgrowth was evaluated ex vivo. The metabolites trimethylamine-N-oxide (TMAO), N, N, N-trimethyl-5-aminovalerate (TMAV), imidazole propionate (IP), 3-indoxyl sulfate (3-IS) and hippurate (HIP) were selected based on their&gt;2-fold reduction in both maternal blood and fetal brain lysates from ABX and GF dams, relative to SPF controls, and their restoration to SPF levels by maternal colonization with Sp bacteria ( FIG. 12I ,  FIG. 13B ). In addition, each metabolite is known to be regulated in adult stool, blood and/or prefrontal cortex by the gut microbiome 8,47,54,55 . Fetal thalamic explants harvested from E14.5 embryos of ABX dams exhibited impaired axonogenesis in response to co-culture with ABX striatal and hypothalamic explants, as previously described ( FIGS. 1J-1M ,  FIG. 5A-5L , white vs. black). Notably, exposure to physiologically-relevant concentrations of TMAO, 5-AV, IP or HIP, but not 3-IS, significantly increased axon number to levels seen in fetal brain explants from embryos of SPF dams ( FIGS. 14A-14C ,  FIG. 15A ). 5-AV and IP also significantly increased axon length, whereas TMAO and 3-IS induced modest, but not statistically significant, increases in axon length, while HIP had no effect ( FIG. 15B ). No statistically significant changes were found in number and length of ABX thalamic axons proximal to hypothalamus in response to TMAO, 5-AV, IP, 3-IS, or HIP ( FIGS. 15C-15D ). To further test whether maternal metabolite supplementation impacts fetal neurodevelopment in vivo, ABX-treated dams were injected intraperitoneally with a cocktail of TMAO, 5-AV, IP, and HIP metabolites (4-MM) or vehicle from E7-14 of gestation, the developmental time frame during which thalamocortical axonogenesis occurs 56,57  Metabolite dosages were calculated based on maternal serum metabolomic data and physiological concentrations reported in literature to reflect daily levels needed to achieve those observed in SPF dams (see Methods section). Notably, maternal supplementation with 4-MM prevented the reductions in Netrin-G1 thalamocortical axons seen with maternal microbiome depletion ( FIGS. 14D-14F ,  FIG. 16A-16D ). Consistent with results from the axon outgrowth assay, these findings suggest that select microbial metabolites, including 4-MM, are important for promoting fetal thalamocortical axonogenesis. Furthermore, adult offspring of ABX dams that were supplemented with 4 MM exhibited improvements in tactile sensory behavior in the von Frey filament and adhesive removal tasks, relative to vehicle-treated ABX controls, which were statistically significant when analyzed by dam ( FIGS. 14G-141 ) as well as by individual offspring ( FIGS. 17A-17C ). There were no significant differences observed between male and female mice in these behavioral tasks ( FIGS. 17D-17F ). Altogether, results from this study reveal that the maternal microbiome promotes fetal thalamocortical axonogenesis and postnatal tactile sensory behavior, likely via microbiome-dependent biochemicals, such as TMAO, 5-AV, IP, and HIP, in the fetal brain. 
     The gut microbiome modulates numerous bioactive molecules in the intestine, serum and various extraintestinal organs 54,58,59 . Findings from this work reveal that during pregnancy, the maternal gut microbiome regulates metabolites, not only in the maternal compartment, but also in the fetus itself, including the embryonic brain. Select fetal brain metabolites that are regulated by the maternal gut microbiome induce axon outgrowth from thalamic explants and promote fetal thalamocortical axonogenesis and adult tactile sensory behavior in offspring of microbiome-depleted dams. While the molecular mechanisms underlying the effects of select microbial metabolites on neurons remain unclear, some metabolites, such as TMAO, TMAV and HIP, have been associated with neurological conditions and factors related to neurite outgrowth 60-65  (Example 3). In addition, findings from this study parallel recent evidence that malnutrition-induced alterations in the maternal microbiome were associated with reduced white matter in the brains of adolescent and adult offspring and that inflammation-induced alterations in the maternal gut microbiome disrupted somatosensory cortical architecture in adult offspring 20,66-69.  Furthermore, a recent study of microbiomes in malnourished children reported that children with severe acute malnutrition exhibited dysregulation of several proteins associated with axonogenesis, including semaphorins, neurotrophins, netrin, slit and ephrin, which were ameliorated by treatment with microbiota-directed diets” 70 . Results presented herein support an important role for the maternal microbiome in promoting offspring neurodevelopment, and further suggest that interactions between the microbiome and nervous system begin prenatally through influences of the maternal gut microbiome on fetal brain metabolomic profiles and gene expression. Altogether, findings from this study identify early to mid-gestation as a critical period during which the maternal microbiome promotes fetal neurodevelopment to support developmental processes underlying adult tactile sensory behavior. 
     Example 2: Methods Used for Example 1 
     Mice 
     C57Bl/6J mice were purchased from Jackson Laboratories, reared as SPF or rederived as GF, and bred in flexible film isolators at the UCLA Center for Health Sciences barrier facility. Animals were maintained on a 12-h light-dark schedule in a temperature-controlled environment with autoclaved “breeder” chow (Lab Diets 5K52) and standard chow (Lab Diet 5010) and autoclaved water provided ad libitum. 
     Sample Size Determination 
     6-8 week-old mice were randomly assigned to experimental groups, which included age- and sex-matched cohorts of males and females for timed matings. Given that maternal microbiome status is the primary experimental variable across experiments, biological sample sizes reflect independent dams. Experiments evaluating fetal outcomes include at least 2 randomly selected embryos per dam, where data from offspring from a single dam were averaged to represent the dam as the biological “n”. For behavioral assays, all offspring were behaviorally tested and data from offspring from the same dam were averaged to represent the dam as the biological “n”. These data are presented in  FIGS. 1A-1M, 6A-6G, 10A-10M, 12A-121, and 14A-141 , whereas behavioral data per individual offspring are presented in the other figures. All experiments were performed in accordance with the NIH Guide for the Care and Use of Laboratory Animals using protocols approved by the Institutional Animal Care and Use Committee at UCLA. 
     Antibiotic Treatment and Conventionalization 
     4-5 week old SPF mice were gavaged twice daily (08:00 and 17:00) for 1 week with a cocktail of neomycin (100 mg/kg), metronidazole (100 mg/kg), and vancomycin (50 mg/kg), according to methods previously described to mimic GF status 71 . Ampicillin (1 mg/ml) was provided ad libitum in drinking water. Breeders were then paired and time-mated, where up to 2 additional weeks were required to conception. Gestational day 0.5 was determined by observation of copulation plug. Dams were then separated and maintained on ABX drinking water until E14.5 to preclude the daily stress of oral gavage in pregnant dams (1 mg/ml ampicillin, 1 mg/ml neomycin, and 0.5 mg/ml vancomycin; metronidazole was excluded due to its confounding bitter taste). Fecal samples from ABX-treated dams were collected and plated anaerobically on Schaedler&#39;s broth and tryptic soy agar to confirm bacterial clearance. For behavioral assays, pregnant dams were conventionalized at E14.5 with SPF bedding that was gathered from a male and female C57Bl/6J cage 72 . Pregnant dams were maintained in SPF bedding for the remainder of gestation, and offspring were reared with SPF bedding, added weekly, until behavioral testing. Conventionalization was validated by fecal 16S rDNA sequencing, as described in the “16S rDNA sequencing” section below. 
     Gnotobiotic Colonization 
     Mice were treated with ABX as described in the “antibiotic treatment” section above, then given sterile water and orally gavaged 1 day later with Sp or BD bacteria. Sp-colonized mice were generated as previously described′. Briefly, fecal pellets from C57Bl/6J SPF mice were freshly suspended in a 10× volume of pre-reduced PBS in an anaerobic chamber. Chloroform was added to 3% (vol/vol), the sample was shaken vigorously and incubated at 37° C. for 1 hr. Chloroform was removed by percolation with CO 2  from a compressed cylinder. 200 ul of the resultant suspension was orally gavaged into adult GF C57Bl/6J “founder” mice housed in designated gnotobiotic isolators. Fecal samples were collected from the Sp mice at &gt;2 weeks after gavage and suspended at 50 mg/ml in pre-reduced PBS. 200 ul of the suspension was orally gavaged to ABX-treated experimental mice. For the  Bacteroides  (BD) consortium,  B. thetaiotaomicron  (ATCC 29148),  B. vulgatus  (ATCC 8482) and  B. uniformis  (ATCC 8492),  B. ovatus  (ATCC 8483) and  B. fragilis  (NCTC 9343) were grown in Brain Heart Infusion media (BD Biosciences) supplemented with 5 μg/ml hemin (Frontier Scientific) and 0.5 μg/ml vitamin K1 (Sigma Aldrich) under anaerobic conditions. A 200 μl suspension of 1:1:1:1:1 OD of each strain was orally gavaged into ABX-treated mice. Colonization status was validated by 16S rDNA sequencing of fecal samples collected on E14.5 ( FIGS. 9B and 11A ). For BD, total relative abundance of  Bacteroides  was 95.24%, and individual species distributions were determined by qPCR as  B. thetaiotaomicron:  9.38%,  B. vulgatus:  18.75% and  B. uniformis:  15.63%,  B. ovatus:  46.88% and  B. fragilis:  9.38%. 
     Fetal Brain RNA Sequencing 
     Dams were sacrificed on E14.5 by cervical dislocation to preclude confounding effects of CO 2  on maternal and fetal physiology. Embryonic brains were microdissected from SPF, ABX, and Sp colonized mice and placed in Trizol (Invitrogen). RNA was extracted using the RNAeasy Mini kit with on-column genomic DNA-digest (Qiagen), and cDNA synthesis was performed using the qScript cDNA synthesis kit (Quantabio). RNA quality of RIN&gt;8.0 was confirmed using the 4200 Tapestation system (Agilent). RNA was prepared using the TruSeq RNA Library Prep kit and 2×69 bp paired-end sequencing was performed using the Illumina HiSeq 4000 platform by the UCLA Neuroscience Genomics Core. FastQC v0.11.8 and HiSAT2 2.1.0 74,75  were used for quality filtering and mapping. Reads were aligned to UCSC Genome Browser assembly ID: mm10. Differential expression analysis was conducted using DESeq2 1.24.0 76 . Heatmaps were generated using the pheatmap package for R. GO term enrichment analysis of differentially expressed genes with q&lt;0.05 was conducted using DAVID v6.8 77 . 
     Quantitative RT-PCR 
     Dams were sacrificed on E14.5 by cervical dislocation to preclude confounding effects of CO 2  on maternal and fetal physiology. Embryonic brains were microdissected on E14.5 and sonicated in Trizol for RNA isolation using the RNAeasy Mini kit with on-column genomic DNA-digest (Qiagen). cDNA synthesis was performed using the qScript cDNA synthesis kit (Quantabio). qRT-PCR was performed on a QuantStudio 5 thermocycler (ThermoFisher Scientific) using SYBR green master mix with Rox passive reference dye and validated primer sets obtained from Primerbank (Harvard). 
     Axon Outgrowth Assay 
     Dams were sacrificed on E14.5 by cervical dislocation to preclude confounding effects of CO 2  on maternal and fetal physiology. Thalamic, striatal, and hypothalamic explants were isolated from E14.5 embryonic brains and transferred to ice-cold HBSS (Invitrogen). Explants were sliced to ˜500 μm and placed on a thin layer of 50 μl BD Matrigel (Beckton Dickinson) on a 15 mm coverslip. Each coverslip contained a thalamic explant at the center and a striatal and hypothalamic explant on each side, at 1 mm equidistant from the thalamic explant. Explants were incubated in warmed neurobasal complete media containing 1× neurobasal medium (Thermofisher Scientific), 1× GlutaMax (Thermofisher Scientific), and 2% B-27 (Thermofisher Scientific) for 48 hrs at 37° C., and fed with fresh media every 24 hrs. After 48 hrs, media was gently aspirated and replaced with 4% PFA for 1 hr and processed for immunofluorescence staining with 1:500 (3 tubulin III anti-mouse antibody (EMD Millipore MAB1637). Axons were imaged using a Leica DMi8 epifluorescence microscope and quantified using Fiji software 78 . Axon numbers were quantified per 200 μm of thalamus at a distance of 200 μm from the thalamus. Length of axons was quantified by averaging length of the 10 longest axons proximal to striatum or hypothalamus. Data for number and length of axons in the explant co-culture system was normalized by subtraction of data from monoculture of thalamic explants from the corresponding experimental group. 
     Metabolite Supplementation 
     Thalamic, striatal, and hypothalamic explants from ABX-treated dams were harvested and cultured as described in the “axon outgrowth assay” section above. For metabolite treatment, BD Matrigel was supplemented with 10 1.1M, 100 nM, or 1 nM of trimethylamine-N-oxide (TMAO), 5-aminovalerate (5-AV), imidazole propionate (IP), 3-indoxyl-sulfate (3-IS), or hippurate (llip) 48,79-81 . 5-aminovalerate is a precursor to N,N,N-trimethyl-5-aminovalerate (TMAV), which is not commercially available, and both are implicated in carnitine metabolism 82,83 . Metabolite concentrations were determined as physiologically relevant, based on reported concentrations detected in blood and/or cerebrum from the mouse multiple tissue metabolomic database (MMIvIDB), human metabolome database (HMDB) and existing literature 48,79-81 . Axons were stained, imaged and analyzed as described in the “axon outgrowth assay” section above. 
     In Vivo Metabolite Supplementation 
     To test the effects of TMAO, 5-AV, IP, and HIP on fetal axonogenesis and behavior, physiological concentrations of metabolites were administered intraperitoneally as a single dose per each day in order to limit stress to pregnant dams. Controls were injected with vehicle. Metabolite concentrations were calculated based on physiological levels reported in mouse blood 48,79-81 , total blood volume of pregnant mouse dams (approximately 58.5 ml/kg 84 ), and relative reductions observed in maternal sera of ABX dams compared SPF dams (Table 5). The metabolite mixture (4-MM): 121 ug (TMAO), 9 ug (5-AV), 92 ug (IP), and 2 ug (HIP) in 200 ul of 0.1 M PBS was injected intraperitoneally into E7.5 ABX dams once a day for 7 days. To assess fetal thalamocortical axon levels, dams treated with 4-MM or vehicle were sacrificed on E14.5, and fetal brains were harvested and processed as described in the “immunofluorescence staining” and “modified CLARITY” sections below. To test for behavioral effects, E14.5 pregnant dams were taken off antibiotic water (ANV) on E14.5, transferred into cages with sterile water, and conventionalized as described in the “conventionalization” section above. Adult offspring (P42-P56) were tested in the von Frey filament test and adhesive removal test as described in the “behavioral assay” section below. 
     Immunofluorescence Staining 
     E14.5 embryos were fixed in 4% paraformaldehyde for 24 hrs at 4° C., cryoprotected in 30% sucrose 24 hrs at 4° C. and sectioned at 10 μm using a Leica CM1950 cryostat. Sections were blocked with 10% donkey serum for 1 hr. Primary antibodies were diluted in 3% donkey serum and incubated for 15-18 hrs at 4° C. with Netrin-G1a anti-goat antibody (1:100, R&amp;D Systems, AF1166) or Neural Cell Adhesion Molecule L1 anti-rat antibody (1:500, EMD Millipore, MAB5272). Sections were then incubated for 2 hrs at room temperature in their corresponding donkey anti-goat and anti-rat secondary antibodies conjugated to Alexa Fluor 568 or 488 (1:1000, Thermofisher Scientific). Images were acquired using the Zeiss Axio Examiner LSM 780 confocal microscope. Rostral to caudal sections were adjusted in Fiji: process&gt;noise&gt;despeckle, to remove non-specific staining. Fluorescence intensity of stains was quantified in Fiji based on a set region of interest drawn to encompass Netrin-G1a staining observed in SPF samples. 
     Tissue Clearing and Imaging 
     E14.5 embryos were collected and fixed in 4% paraformaldehyde for 48 hours at 4° C. Tissue was rendered transparent using methods for CLARITY-based clearing 85  with the following modifications. Tissues were incubated in a hydrogel solution containing 4% paraformaldehyde, 4% acrylamide (Bio-Rad), 0.05% bis-acrylamide (Bio-Rad), 0.25% VA-044 (A4P4B0.05) for 3 days at 4° C. Prior to hydrogel polymerization, the solution was exchanged with new solution lacking bis-acrylamide and paraformaldehyde (A4PO4) and polymerized at 37° C. for 3 hrs. Samples were passively cleared in 8% SDS for 2 weeks at 42° C., and then incubated with primary antibodies (Netrin-G1 a anti-goat (1:100, R&amp;D Systems, AF1166) and L1 anti-rat (1:500, EMD Millipore, MAB5272)) for 1 week at 25° C. Samples were washed and then incubated in secondary antibodies (1:1000, Thermofisher Scientific) for 5 days at 25° C. Samples were equilibrated for 15-18 hrs in a histodenz-based refractive index matching solution (RI 1.47; Sigma Aldrich, D2158) and imaged on a Zeiss LSM 780 with 488 or 561 nm illumination using a 5× objective with 3 um z-slices. Images were adjusted for brightness and contrast post hoc using Arivis Vision4D v3.0. 3D reconstructions were optically z-sliced for quantification of stain volume, length of axons, circumference of internal capsule and distance of rostral axon tip to cortical surface. Positively stained areas of interest were segmented and visualized using CTAn and CTVol software packages (Bruker Corporation), respectively. 
     Behavioral Assays 
     For behavioral assays, investigators were blinded to experimental groups. For each behavioral test, cages were brought to the testing room at least 30 minutes before testing to enable acclimation and reduce stress. Equipment and testing chambers were thoroughly cleaned with Accel disinfectant (Unimed) before and after each trial. 
     Adhesive Removal Test 
     The adhesive removal test was performed according to methods adapted from Bouet et al. 2009 37 . Briefly, mice were acclimated to the testing cage for 5 min A small adhesive tape (0.3 cm×0.4 cm) was gently applied to both forepaws, and mice were returned to the testing cage. Mice were observed for contact time, as defined as the latency to which the mouse reacts to the presence of the adhesive tape, and for removal time, as defined as the latency to which the mouse removes both pieces of tape completely. Contact time and removal time were manually recorded using a standard lab multi-timer by experimenters blinded to the mouse experimental group. 
     Von Frey Filament Test 
     The von Frey filament test was performed according to methods adapted from Dixon et al., 1980 86 . Briefly, mice were placed on a wide gauge, wire mesh surface in a testing chamber and acclimated for 10 minutes daily for two consecutive days prior to testing day. On the testing day, mice were placed in the testing chamber, acclimated for 10 minutes, and von Frey filaments were applied from the underside of the mesh to the plantar surface of the hindpaw. The process is repeated with increasing gauges (0.4, 0.6, 1, 1.4, 2, 4, 6 grams of force) of von Frey filaments until stimulation elicits a hindpaw withdrawal, wherein the mouse responds by flicking its paw away from the stimulus. Upon paw withdrawal, the next weaker stimulus is defined as threshold. Responses of up-down paw stimulation were manually recorded and analyzed according to the Chaplan Method of 50% paw withdrawal threshold 36 . 
     Prepulse Inhibition Test 
     The prepulse inhibition test was performed to measure sensorimotor gating 87 . Mice were placed in a restraint tube mounted on a startle measuring platform (San Diego Instruments) and acclimated to the testing chamber for 10 minutes. White noise is presented in the recording chamber for 5 minutes, followed by 6 startle presentations and a pseudorandomized prepulse inhibition phase, which consisted of either no startle, 120 db startle stimulus only, or 70 db prepulse with startle, 75 db prepulse with startle, or 80 db prepulse with startle. Acoustic startle was recorded with a pliezo-electric sensory, and the percent prepulse inhibition was defined as: [((the startle stimulus only−prepulse with startle)/startle stimulus only)*100]. 
     Hot Plate Test 
     To test for somatic pain response 1 , mice were acclimated to a clear plastic cylinder for 30 s, then placed on an advanced hot plate (VWR) that was heated to 52° C. The latency to show nociceptive response as indicated by a paw lick, paw flick, vocalization, or a jump was recorded, and mouse was immediately returned to the home cage. 
     Novel Whisker Texture Test 
     The whisker texture test was performed according to methods adapted from Wu et al., 2013 2 . Mice were habituated in 50 cm×50 cm white plexiglass testing chamber for 10 minutes for 2 consecutive days. On testing day, mice were first subjected to a learning phase in which they were placed in the testing chamber for 5 minutes with two objects of identical texture (aluminum oxide sand paper, 80 grit). Mice were then returned to home cage for 5 minutes. In the test phase, mice were placed back into chamber with two objects, one with the original texture (80 grit) and one with new texture (220 grit). The trials were recorded with an overhead video camera and Ethovision software (Noldus) was used to analyze number of times and duration spent investigating the novel and familiar textures. 
     Visual Cliff Avoidance Test 
     To assess depth perception and visual impairment 3 , mice were placed in a 42.5 cm×60 cm clear plexiglass testing chamber on top of a 3 ft×4 ft rectangular table. One third of the chamber hung over the edge of the table to create a visual effect of a cliff drop-off at a height of 3 ft. Mice were placed in the middle of the chamber 10 times. Mice were given 5 minutes to either exit off the platform towards the table or toward the cliff side of the chamber. Each choice was recorded and averaged by an experimenter blinded to mouse experimental group. 
     Rotarod Test 
     To test for motor coordination and balance 4 , mice were placed in one of 4 compartments in a rotarod apparatus (Rotamex, Columbus Instruments) consisting of a cylinder that rotates speeds accelerating from 5 rpm to 60 rpm in 300 seconds. On the first day, mice acclimated to the apparatus with no rotation for 2 minutes. On the testing day, mice were returned to the apparatus and rotation was initiated. Latency to fall and final speed achieved by the accelerating rod before falling was detected by an infrared sensor and recorded. Mice were tested three times and scores were averaged. 
     16S rDNA Sequencing 
     Bacterial genomic DNA was extracted from mouse fecal samples using the MoBio PowerSoil Kit. The library was generated according to methods adapted from Caporaso et al. 2011 88 . The V4 regions of the 16S rRNA gene were PCR amplified using individually barcoded universal primers and 30 ng of the extracted genomic DNA. The PCR reaction was set up in triplicate, and the PCR product was purified using the Qiaquick PCR purification kit (Qiagen). 250 ng of purified PCR product from each sample were pooled and sequenced by Laragen, Inc. using the Illumina MiSeq platform and 2×250 bp reagent kit for paired-end sequencing. Operational taxonomic units (OTUs) were chosen by open reference OTU picking based on 97% sequence similarity to the Greengenes 13_5 database. Taxonomy assignment and rarefaction were performed using QIIME1.8.0 89 . 
     Metabolomics 
     At E14.5 maternal serum was collected by cardiac puncture, separated using SST vacutainer tubes (Beckton Dickinson) and frozen at −80° C. Embryonic brains were collected and immediately snap frozen in liquid nitrogen. Each fetal brain sample consisted of 5 embryonic brains pooled from the same litter. Samples were prepared using the automated MicroLab STAR system (Hamilton Company) and analyzed on GC/MS, LC/MS and LC/MS/MS platforms by Metabolon, Inc. Protein fractions were removed by serial extractions with organic aqueous solvents, concentrated using a TurboVap system (Zymark) and vacuum dried. For LC/MS and LC-MS/MS, samples were reconstituted in acidic or basic LC-compatible solvents containing &gt;11 injection standards and run on a Waters ACQUITY UPLC and Thermo-Finnigan LTQ mass spectrometer, with a linear ion-trap frontend and a Fourier transform ion cyclotron resonance mass spectrometer back-end. For GC/MS, samples were derivatized under dried nitrogen using bistrimethyl-silyl-trifluoroacetamide and analyzed on a Thermo-Finnigan Trace DSQ fast-scanning single-quadrupole mass spectrometer using electron impact ionization. Chemical entities were identified by comparison to metabolomic library entries of purified standards. Following log transformation and imputation with minimum observed values for each compound, data were analyzed using one-way ANOVA to test for group effects. P and q-values were calculated based on two-way ANOVA contrasts. Principal components analysis was used to visualize variance distributions. Supervised Random Forest analysis was conducted to identify metabolomics prediction accuracies. Volcano plots were generated using R, with differentially regulated metabolites at q&lt;0.05. 
     Statistical Methods 
     Statistical analysis was performed using Prism software (GraphPad). Data were assessed for normal distribution and plotted in the figures as mean±SEM. For each figure, n=the number of independent maternal biological replicates. For assessments involving fetal brains, each maternal biological sample reflects an average of 2-5 embryo “technical” replicates. For behavioral assessments, all offspring were tested. Data for littermates from the same dam were averaged and presented in the  FIGS. 1A-1M, 6A-6G, 10A-10M, 12A-12I, and 14A-14I  with n=independent maternal dams; individual data for each offspring are provided in the other figures. No samples or animals were excluded from the analyses. Differences among &gt;2 groups with only one variable were assessed using one-way ANOVA with Tukey&#39;s post hoc test. Taxonomic comparisons from 16S rDNA sequencing analysis were analyzed by Kruskal-Wallis test with Tukey&#39;s post hoc test. Two-way ANOVA with Tukey&#39;s post-hoc test was used for &gt;2 groups with two variables. Significant differences emerging from the above tests are indicated in the figures by *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001. Notable non-significant differences are indicated in the figures by “n.s.”. 
     Example 3: Additional Discussion Regarding Example 1 
     Gut Microbiota Modulation of Axons and Myelination 
     Results from this study reveal that the maternal microbiome promotes fetal thalamocortical axonogenesis. We observe deficiencies in L1 and Netrin-G1a expression in E14.5 brains of ABX dams ( FIGS. 1B-1D ). Consistent with a previous report, we observe only modest changes in L1 expression in E14.5 brains of fetuses from GF dams relative to SPF controls 90  ( FIGS. 1B-1D ), pointing to potential compensatory effects of GF rearing as compared to acute microbiome depletion. Our finding extends several previous reports that the gut microbiota modulates axon structure and axonal myelination in adult animals. Adolescent (4 weeks) and adult (12 weeks) GF mice display reduced white matter structure in the corpus callosum, anterior commissure and internal capsule 20 , which is a defining anatomical structure for thalamocortical axon projections ( FIGS. 1E-1I ). Consistent with this, brains of GF mice also exhibit reduced expression of neuronal (NeuN), axonal (neurofilament-L), and myelination (MBP) markers relative to control mice colonized with a healthy human microbiota 19 . In a recent ultrastructural study, microbiota depleted mice exhibited reduced axon diameter and increased myelination in the brain′. Finally, children aged 6-36 months with healthy microbiome exhibit increased expression of central nervous system development proteins compared to children with severe acute malnutrition microbiomes. These proteins are associated with axonogenesis, including semaphorins (SEMA3A, SEMA5A, SEMA6A, SEMA6B), neurotrophins (NTRK2, NTRK3), netrin (UNC5D), slit (SLITRK5) and ephrin (EFNA5), which were ameliorated by treatment with microbiota-directed diets”. Microbiome-dependent alterations in axons may extend beyond the brain itself, as adult GF and ABX-treated mice exhibited reduced axonal innervations of the colonic epithelium 17  and ABX treatment of a mouse model of multiple sclerosis increased axon numbers in the spinal cord 92 . Altogether, we propose that the maternal gut microbiome during pregnancy plays an important role in regulating fetal thalamocortical axonogenesis, 
     Potential Mechanisms of Microbially Modulated Metabolites 
     Results from this study indicate that the maternal microbiome modulates numerous biochemicals in the fetal brain, and that select metabolites—TMAO, 5-AV, IP, and HIP—promote fetal thalamocortical axonogenesis and offspring tactile sensory behavior. While microbiome-dependent regulation of TMAO, 5-AV, IP and HIP has been reported across metabolomic datasets for adult mouse and human blood, urine, and/or intestine 48,54,93,94 , little is known regarding the functional roles for each metabolite on host physiology. 
     Dysregulation of TMAO, produced through a two-step enzymatic process performed by gut microbes and the liver, has been implicated in metabolic, cardiovascular, cerebrovascular, stroke and Alzheimer&#39;s disease 62,64,95  Although a cognate receptor for TMAO has not been described, TMAO is reported to modulate glucocorticoid receptors and the Gi3y subunit of GPCRs, to promote protein stability and folding as an organic osmolyte, and to regulate the phosphorylation of insulin-like growth factor 2 (IGF2) 96-99 . Such effects on IGF2 have been reported to increase sympathetic neurite outgrowth 100 , which could be relevant to the observed axonogenic effects of TMAO on thalamocortical neurons. 
     TMAV is metabolized from dietary glycine and is associated with glucose metabolism and diets rich in whole grain 82,94,101 . Increases in TMAV have been associated with type 1 diabetes with microalbuminuria and metformin-treated type 2 diabetes 102,103 , but the relation of TMAV to axon or brain development has not been previously reported. 5-AV, a precursor for TMAV, is microbially produced from L-lysine. L-lysine monooxygenase (DavB) and 5-aminovaleramide amidohydrolase (DavA) are key enzymes in the 5-AV pathway, whereby DavB catalyzes the oxidation of L-lysine to produce 5-aminovaleramide; DavA then converts 5-aminovaleramide into 5-AV 104,105 . 5-AV has been shown to negatively regulate baclofen, a GABAB receptor agonist, to suppress naloxone-stimulated luteinizing hormone-releasing hormone 106 . Further, 5-AV has been associated with reductions in the inhibitory effect of baclofen on norepinephrine release from noradrenergic terminals 106 . Separately, application of 5-AV onto rat hippocampal slices reduced pyramidal cell GABAB-mediated ICE inhibitory postsynaptic potential (IPSP) 107 . Though the exact mechanism by which 5-AV alters axon outgrowth is unclear, one hypothesis is that the influences of 5-AV on GABAB receptors, which are key regulators of synaptic release and axonal trafficking 108,109 , can impact cortical neuronal migration and axon/dendrite morphological maturation by modulating cAMP signaling 110,111 . 
     IP is a product of direct microbial, but not murine, metabolism 47 . IP is a microbial metabolite derived from histidine and has been reported to impair insulin signaling through mTORC1 48 . IP is associated with nonalcoholic fatty liver disease and is a potential inducer of steatosis and hepatic inflammation 112,113 . In another study, IP was found in urine of IBS patients 112,113. There have been no previous reports of IP regulation of axon development, however, activation of mTOR has been shown to increase axonal growth capacity 114  and promote axon regeneration after injury or disease 115,116 . 
     HIP, synthesized through glycine conjugation with benzoate in the liver, is a metabolite of folic acid, which affects neural tube formation and brain development 65 . Decreased excretion of HIP has been described in patients with schizophrenia, depression, stroke, autism, and gastrointestinal disorder, and in animal models of acute and chronic stress 117-119 . While HIP has not been previously implicated in axon development, the HIP precursor, benzoate, has been shown to have anti-inflammatory properties and to reduce microglial and astroglial inflammatory responses in the experimental autoimmune encephalomyelitits (EAE) model of multiple sclerosis 120 . 
     Overall, a few previous reports have associated altered microbiome-related metabolites with altered neurodevelopment and adverse neurological outcomes. However, extensive further research is needed to uncover functional roles for microbially-modulated metabolites on host health and disease, and to identify the molecular and cellular mechanisms underlying the axonogenic effects of TMAO, 5-AV, IP and HIP on thalamic neurons. 
     Example 4: References for Examples 1-3 
     
         
         1 Vuong, H. E., Yano, J. M., Fung, T. C. &amp; Hsiao, E. Y. The Microbiome and Host Behavior.  Annu Rev Neurosci  40, 21-49, doi:10.1146/annurev-neuro-072116-031347 (2017). 
         2 Clarke, G. et al. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner.  Molecular psychiatry  18, 666-673, doi:10.1038/mp.2012.77 (2013). 
         3 Phelps, D. et al. Microbial colonization is required for normal neurobehavioral development in zebrafish.  Sci Rep  7, 11244, doi:10.1038/s41598-017-10517-5 (2017). 
         4 Sharon, G. et al. Commensal bacteria play a role in mating preference of  Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America  107, 20051-20056, doi:10.1073/pnas.1009906107 (2010). 
         5 Bravo, J. A. et al. Ingestion of  Lactobacillus  strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.  Proceedings of the National Academy of Sciences of the United States of America  108, 16050-16055, doi:10.1073/pnas.1102999108 (2011). 
         6 Buffington, S. A. et al. Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring.  Cell  165, 1762-1775, doi:10.1016/j.cell.2016.06.001 (2016). 
         7 Hsiao, E. Y. et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.  Cell  155, 1451-1463, doi:10.1016/j.cell.2013.11.024 (2013). 
         8 Olson, C. A. et al. The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.  Cell  174, 497, doi:10.1016/j.cell.2018.06.051 (2018). 
         9 Kim, S. et al. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.  Nature  549, 528-532, doi:10.1038/nature23910 (2017). 
         10 Shin Yim, Y. et al. Reversing behavioural abnormalities in mice exposed to maternal inflammation.  Nature  549, 482-487, doi:10.1038/nature23909 (2017). 
         11 De Palma, G. et al. Microbiota and host determinants of behavioural phenotype in maternally separated mice.  Nature communications  6, 7735, doi:10.1038/ncomms8735 (2015). 
         12 Jasarevic, E. et al. The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus.  Nat Neurosci  21, 1061-1071, doi:10.1038/s41593-018-0182-5 (2018). 
         13 Backhed, F. et al. Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life.  Cell Host Microbe  17, 690-703, doi:10.1016/j.chom.2015.04.004 (2015). 
         14 Ferretti, P. et al. Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome.  Cell Host Microbe  24, 133-145 e135, doi:10.1016/j.chom.2018.06.005 (2018). 
         15 Mueller, N. T., Bakacs, E., Combellick, J., Grigoryan, Z. &amp; Dominguez-Bello, M. G. The infant microbiome development: mom matters.  Trends Mol Med  21, 109-117, doi:10.1016/j.molmed.2014.12.002 (2015). 
         16 Nakashiba, T. et al. Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins.  I Neurosci  20, 6540-6550 (2000). 
         17 De Vadder, F. et al. Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks.  Proc Natl Acad Sci USA  115, 6458-6463, doi:10.1073/pnas.1720017115 (2018). 
         18 Gacias, M. et al. Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior.  eLife  5, doi:10.7554/eLife.13442 (2016). 
         19 Lu, J. et al. Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice.  Scientific reports  8, 5443, doi:10.1038/s41598-018-23692-w (2018). 
         20 Lu, J. et al. Microbiota influence the development of the brain and behaviors in C57BL/6J mice.  PLoS One  13, e0201829, doi:10.1371/journal.pone.0201829 (2018). 
         21 Rennie, S., Lotto, R. B. &amp; Price, D. J. Growth-promoting interactions between the murine neocortex and thalamus in organotypic co-cultures.  Neuroscience  61, 547-564 (1994). 
         22 Yamada, A. et al. Role of pre- and postsynaptic activity in thalamocortical axon branching.  Proc Nall Acad Sci USA  107, 7562-7567, doi:10.1073/pnas.0900613107 (2010). 
         23 Braisted, J. E. et al. Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection.  J Neurosci  20, 5792-5801 (2000). 
         24 Mitsogiannis, M. D., Little, G. E. &amp; Mitchell, K. J. Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance.  Neural Dev  12, 6, doi:10.1186/s13064-017-0083-4 (2017). 
         25 Braisted, J. E., Ringstedt, T. &amp; O&#39;Leary, D. D. Slits are chemorepellents endogenous to hypothalamus and steer thalamocortical axons into ventral telencephalon.  Cereb Cortex  19 Suppl 1, i144-151, doi:10.1093/cercor/bhp035 (2009). 
         26 Braisted, J. E., Tuttle, R. &amp; O&#39;Leary D, D. Thalamocortical axons are influenced by chemorepellent and chemoattractant activities localized to decision points along their path.  Dev Biol  208, 430-440, doi:10.1006/dbio.1999.9216 (1999). 
         27 Song, H. et al. Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.  Science  281, 1515-1518, doi:10.1126/science.281.5382.1515 (1998). 
         28 Song, H. J., Ming, G. L. &amp; Poo, M. M. cAMP-induced switching in turning direction of nerve growth cones.  Nature  388, 275-279, doi:10.1038/40864 (1997). 
         29 Stevens, A. &amp; Jacobs, J. R. Integrins regulate responsiveness to slit repellent signals.  J Neurosci  22, 4448-4455, doi:20026413 (2002). 
         30 Dontchev, V. D. &amp; Letourneau, P. C. Nerve growth factor and semaphorin 3A signaling pathways interact in regulating sensory neuronal growth cone motility.  J Neurosci  22, 6659-6669, doi:20026638 (2002). 
         31 Enriquez-Barreto, L., Palaz7etti, C., Brennaman, L. H., Maness, P. F. &amp; Fairen, A. Neural cell adhesion molecule, NCAM, regulates thalamocortical axon pathfinding and the organization of the cortical somatosensory representation in mouse.  Front Mol Neurosci  5, 76, doi:10.3389/fnmo1.2012.00076 (2012). 
         32 Leingartner, A. et al. Cortical area size dictates performance at modality-specific behaviors.  Proc Nall Acad Sci USA  104, 4153-4158, doi:10.1073/pnas.0611723104 (2007). 
         33 Li, C. X., Chappell, T. D., Ramshur, J. T. &amp; Waters, R. S. Forelimb amputation-induced reorganization in the ventral posterior lateral nucleus (VPL) provides a substrate for large-scale cortical reorganization in rat forepaw barrel subfield (FBS).  Brain Res  1583, 89-108, doi:10.1016/j.brainres.2014.07.022 (2014). 
         34 Petersen, C. C. The functional organization of the barrel cortex.  Neuron  56, 339-355, doi:10.1016/j.neuron.2007.09.017 (2007). 
         35 Xiong, W. et al. Enhancing excitatory activity of somatosensory cortex alleviates neuropathic pain through regulating homeostatic plasticity.  Sci Rep  7, 12743, doi:10.1038/s41598-017-12972-6 (2017). 
         36 Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M. &amp; Yaksh, T. L. Quantitative assessment of tactile allodynia in the rat paw.  J Neurosci Methods  53, 55-63 (1994). 
         37 Bouet, V. et al. The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice.  Nat Protoc  4, 1560-1564, doi:10.1038/nprot.2009.125 (2009). 
         38 Eddy, N. B. &amp; Leimbach, D. Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines. 1  Pharmacol Exp Ther  107, 385-393 (1953). 
         39 Fox, M. W. The visual cliff test for the study of visual depth perception in the mouse.  Anim Behav  13, 232-233 (1965). 
         40 Wu, H. P., Ioffe, J. C., Iverson, M. M., Boon, J. M. &amp; Dyck, R. H. Novel, whisker-dependent texture discrimination task for mice.  Behav Brain Res  237, 238-242, doi:10.1016/j.bbr.2012.09.044 (2013). 
         41 Deacon, R. M. Measuring motor coordination in mice.  J Vis Exp , e2609, doi:10.3791/2609 (2013). 
         42 Valsamis, B. &amp; Schmid, S. Habituation and prepulse inhibition of acoustic startle in rodents.  J Vis Exp , e3446, doi:10.3791/3446 (2011). 
         43 Turnbaugh, P. J. et al. A core gut microbiome in obese and lean twins.  Nature  457, 480-484, doi:10.1038/nature07540 (2009). 
         44 Belkaid, Y. &amp; Hand, T. W. Role of the microbiota in immunity and inflammation.  Cell  157, 121141, doi:10.1016/j.cell.2014.03.011 (2014). 
         45 Labus, J. S. et al. Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome.  Microbiome  5, 49, doi:10.1186/s40168-017-0260-z (2017). 
         46 Schretter, C. E. et al. A gut microbial factor modulates locomotor behaviour in  Drosophila. Nature  563, 402-406, doi:10.1038/s41586-018-0634-9 (2018). 
         47 Fujisaka, S. et al. Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites.  Cell Rep  22, 3072-3086, doi:10.1016/j.celrep.2018.02.060 (2018). 
         48 Koh, A. et al. Microbially Produced Imidsyole Propionate Impairs Insulin Signaling through mTORC1 . Cell  175, 947-961 e917, doi:10.1016/j.cell.2018.09.055 (2018). 
         49 Schugar, R. C. et al. The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.  Cell Rep  19, 2451-2461, doi:10.1016/j.celrep.2017.05.077 (2017). 
         50 Buss, C., Entringer, S. &amp; Wadhwa, P. D. Fetal programming of brain development: intrauterine stress and susceptibility to psychopathology.  Sci Signal  5, pt 7, doi:10.1126/scisignal.2003406 (2012). 
         51 Monk, C., Georgieff, M. K. &amp; Osterholm, E. A. Research review: maternal prenatal distress and poor nutrition—mutually influencing risk factors affecting infant neurocognitive development.  J Child Psychol Psychiatry  54, 115-130, doi:10.1111/jcpp.12000 (2013). 
         52 Braniste, V. et al. The gut microbiota influences blood-brain barrier permeability in mice.  Sci Transl Med  6, 263ra158, doi:10.1126/scitranslmed.3009759 (2014). 
         53 Saunders, N. R., Liddelow, S. A. &amp; Dziegielewska, K. M. Barrier mechanisms in the developing brain.  Front Pharmacol  3, 46, doi:10.3389/fphar.2012.00046 (2012). 
         54 Wikoff, W. R. et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites.  Proc Natl Acad Sci USA  106, 3698-3703, doi:10.1073/pnas.0812874106 (2009). 
         55 Matsumoto, M. et al. Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study.  Frontiers in systems neuroscience  7, 9, doi:10.3389/fnsys.2013.00009 (2013). 
         56 Anton-Bolanos, N. et al. Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice.  Science  364, 987-990, doi:10.1126/science.aav7617 (2019). 
         57 Molnar, Z., Garel, S., Lopez-Bendito, G., Maness, P. &amp; Price, D. J. Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain.  Eur . 1  Neurosci  35, 15731585, doi:10.1111/j.1460-9568.2012.08119.x (2012). 
         58 Vernocchi, P., Del Chierico, F. &amp; Putignani, L. Gut Microbiota Profiling: Metabolomics Based Approach to Unravel Compounds Affecting Human Health.  Front Microbiol  7, 1144, doi:10.3389/fmicb.2016.01144 (2016). 
         59 Holmes, E., Li, J. V., Athanasiou, T., Ashrafian, H. &amp; Nicholson, J. K. Understanding the role of gut microbiome-host metabolic signal disruption in health and disease.  Trends Microbiol  19, 349359, doi:10.1016/j.tim.2011.05.006 (2011). 
         60 Barrea, L. et al. Trimethylamine-N-oxide (TMAO) as Novel Potential Biomarker of Early Predictors of Metabolic Syndrome.  Nutrients  10, doi:10.3390/nu10121971 (2018). 
         61 Cai, H. L. et al. Metabolomic analysis of biochemical changes in the plasma and urine of first-episode neuroleptic-naive schizophrenia patients after treatment with risperidone. .1  Proteome Res  11, 4338-4350, doi:10.1021/pr300459d (2012). 
         62 Haghikia, A. et al. Gut Microbiota-Dependent Trimethylamine N-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes.  Arterioscler Thromb Vasc Biol  38, 2225-2235, doi:10.1161/ATVBAHA.118.311023 (2018). 
         63 Li, D. et al. Trimethylamine-N-oxide promotes brain aging and cognitive impairment in mice.  Aging Cell, e 12768, doi:10.111 1 / a ce1.12768 (2018). 
         64 Vogt, N. M. et al. The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer&#39;s disease.  Alzheimers Res Ther  10, 124, doi:10.1186/s13195-018-0451-2 (2018). 
         65 Webb, R. E., Shah, E. &amp; Stokstad, E. L. Effect of folic acid and vitamin B-12 on excretion of hippuric acid and formiminoglutamic acid.  Proc Soc Exp Biol Med  121, 19-24, doi:10.3181/00379727-121-30685 (1966). 
         66 Ong, I. M. et al. Gut microbiome populations are associated with structure-specific changes in white matter architecture.  Transl Psychiatry  8, 6, doi:10.1038/s41398-017-0022-5 (2018). 
         67 Indrio, F. et al. Epigenetic Matters: The Link between Early Nutrition, Microbiome, and Longterm Health Development.  Front Pediatr  5, 178, doi:10.3389/fped.2017.00178 (2017). 
         68 Keunen, K., van Elburg, R. M., van Bel, F. &amp; Benders, M. J. Impact of nutrition on brain development and its neuroprotective implications following preterm birth.  Pediatr Res  77, 148155, doi:10.1038/pr.2014.171 (2015). 
         69 Ou, X., Thakali, K. M., Shankar, K., Andres, A. &amp; Badger, T. M. Maternal adiposity negatively influences infant brain white matter development.  Obesity  ( Silver Spring ) 23, 1047-1054, doi:10.1002/oby.21055 (2015). 
         70 Gehrig, J. L. et al. Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.  Science  365, doi:10.1126/science.aau4732 (2019). 
         71 Reikvam, D. H. et al. Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression.  PLoS One  6, e17996, doi:10.1371/journal.pone.0017996 (2011). 
         72 McVey Neufeld, K. A., Perez-Burgos, A., Mao, Y. K., Bienenstock, J. &amp; Kunze, W. A. The gut microbiome restores intrinsic and extrinsic nerve function in germ-free mice accompanied by changes in calbindin.  Neurogastroenterol Motil  27, 627-636, doi:10.1111/nmo.12534 (2015). 
         73 Yano, J. M. et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.  Cell  161, 264-276, doi:10.1016/j.cell.2015.02.047 (2015). 
         74 Kim, D., Langmead, B. &amp; Salzberg, S. L. HISAT: a fast spliced aligner with low memory requirements.  Nat Methods  12, 357-360, doi:10.1038/nmeth.3317 (2015). 
         75 Pertea, M., Kim, D., Pertea, G. M., Leek, J. T. &amp; Salzberg, S. L. Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown.  Nat Protoc  11, 16501667, doi:10.1038/nprot.2016.095 (2016). 
         76 Love, M. I., Huber, W. &amp; Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 . Genome Biol  15, 550, doi:10.1186/s13059-014-0550-8 (2014). 
         77 Huang da, W., Sherman, B. T. &amp; Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.  Nat Protoc  4, 44-57, doi:10.1038/nprot.2008.211 (2009). 
         78 Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis.  Nat Methods  9, 676-682, doi:10.1038/nmeth.2019 (2012). 
         79 Mishima, E. et al. Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS-based metabolomics approach.  Kidney Int  92, 634-645, doi:10.1016/j.kint.2017.02.011 (2017). 
         80 Soga, T. et al. Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption.  I Biol Chem  281 , 16768-16776, doi:10.1074/jbc.M601876200 (2006). 
         81 Soga, T. et al. Quantitative metabolome analysis using capillary electrophoresis mass spectrometry. 0.1  Proteome Res  2, 488-494 (2003). 
         82 Karkkainen, O. et al. Whole grain intake associated molecule 5-aminovaleric acid betaine decreases beta-oxidation of fatty acids in mouse cardiomyocytes.  Sci Rep  8 , 13036, doi:10.1038/s41598-018-31484-5 (2018). 
         83 Fothergill, J. C. &amp; Guest, J. R. Catabolism of L-lysine by  Pseudomonas aeruginosa. J Gen Microbiol  99, 139-155, doi:10.1099/00221287-99-1-139 (1977). 
         84 Diehl, K. H. et al. A good practice guide to the administration of substances and removal of blood, including routes and volumes. .1 −    Appl Toxicol  21, 15-23 (2001). 
         85 Chung, K. et al. Structural and molecular interrogation of intact biological systems.  Nature  497, 332-337, doi:10.1038/nature12107 (2013). 
         86 Deuis, J. R., Dvorakova, L. S. &amp; Vetter, I. Methods Used to Evaluate Pain Behaviors in Rodents.  Front Mol Neurosci  10, 284, doi:10.3389/fnmo1.2017.00284 (2017). 
         87 Perry, W., Minassian, A., Lopez, B., Maron, L. &amp; Lincoln, A. Sensorimotor gating deficits in adults with autism.  Biol Psychiatry  61, 482-486, doi:10.1016/j.biopsych.2005.09.025 (2007). 
         88 Caporaso, J. G. et al. Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample.  Proceedings of the National Academy of Sciences of the United States of America  108 Suppl 1, 4516-4522, doi:10.1073/pnas.1000080107 (2011). 
         89 Caporaso, J. G. et al. QI1ME allows analysis of high-throughput community sequencing data.  Nature methods  7, 335-336, doi:10.1038/nmeth.f.303 (2010). 
         90 Thion, M. S. et al. Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner.  Cell  172, 500-516 e516, doi:10.1016/j.cell.2017.11.042 (2018). 
         91 Radulescu, C. I. et al. Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease.  Neurobiol Dis  127, 65-75, doi:10.1016/j.nbd.2019.02.011 (2019). 
         92 Mestre, L. et al. Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive Multiple Sclerosis.  Front Immunol  10, 1374, doi:10.3389/fimmu.2019.01374 (2019). 
         93 Zhu, W. et al. Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.  Cell  165, 111-124, doi:10.1016/j.cell.2016.02.011 (2016). 
         94 Koistinen, V. M. et al. Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation.  Microbiome  7, 103, doi:10.1186/s40168-019-0718-2 (2019). 
         95 Janeiro, M. H., Ramirez, M. J., Milagro, F. I., Martinez, J. A. &amp; Solas, M. Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target.  Nutrients  10, doi:10.3390/nu10101398 (2018). 
         96 Kumar, R., Lee, J. C., Bolen, D. W. &amp; Thompson, E. B. The conformation of the glucocorticoid receptor afl/taul domain induced by osmolyte binds co-regulatory proteins.  I—Biol Chem  276, 18146-18152, doi:10.1074/jbc.M100825200 (2001). 
         97 Schugar, R. C., Willard, B., Wang, Z. &amp; Brown, J. M. Postprandial gut microbiota-driven choline metabolism links dietary cues to adipose tissue dysfunction.  Adipocyte  7, 49-56, doi:10.1080/21623945.2017.1398295 (2018). 
         98 Seldin, M. M. et al. Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-kappaB.  J Am Heart Assoc  5, doi:10.1161/JAHA.115.002767 (2016). 
         99 Zou, Q., Bennion, B. J., Daggett, V. &amp; Murphy, K. P. The molecular mechanism of stabilization of proteins by TMAO and its ability to counteract the effects of urea.  J Am Chem Soc  124, 11921202, doi:10.1021/ja004206b (2002). 
         100 Jeong, E. Y. et al. Enhancement of IGF-2-induced neurite outgrowth by IGF-binding protein-2 and osteoglycin in SH-SYSY human neuroblastoma cells.  Neurosci Lett  548, 249-254, doi:10.1016/j.neulet.2013.05.038 (2013). 
         101 Karkkainen, O. et al. Diets rich in whole grains increase betainized compounds associated with glucose metabolism.  Am . 1 −    Clin Nutr  108, 971-979, doi:10.1093/ajcninqy169 (2018). 
         102 Adam, J. et al. Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues.  Diabetes  65, 3776-3785, doi:10.2337/db16-0512 (2016). 
         103 Haukka, J. K. et al. Metabolomic Profile Predicts Development of Microalbuminuria in Individuals with Type 1 Diabetes.  Sci Rep  8, 13853, doi:10.1038/s41598-018-32085-y (2018). 
         104 Revelles, O., Espinosa-Urgel, M., Fuhrer, T., Sauer, U. &amp; Ramos, J. L. Multiple and interconnected pathways for L-lysine catabolism in  Pseudomonas putida  KT2440 . J Bacteriol  187, 7500-7510, doi:10.1128/JB.187.21.7500-7510.2005 (2005). 
         105 Revelles, 0., Espinosa-Urgel, M., Molin, S. &amp; Ramos, J. L. The davDT operon of  Pseudomonas putida , involved in lysine catabolism, is induced in response to the pathway intermediate delta-aminovaleric acid.  J Bacteriol  186, 3439-3446, doi:10.1128/JB.186.11.3439-3446.2004 (2004). 
         106 Masotto, C., Wisniewski, G. &amp; Negro-Vilar, A. Different gamma-aminobutyric acid receptor subtypes are involved in the regulation of opiate-dependent and independent luteinizing hormone-releasing hormone secretion.  Endocrinology  125, 548-553, doi:10.1210/endo-125-1-548 (1989). 
         107 Domann, R., Dorn, T. &amp; Witte, 0. W. Afterpotentials following penicillin-induced paroxysmal depolarizations in rat hippocampal CA1 pyramidal cells in vitro.  Pflugers Arch  417, 469-478 (1991). 
         108 Dinamarca, M. C. et al. Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing.  Nat Commun  10, 1331, doi:10.1038/s41467-019-09164-3 (2019). 
         109 Biermann, B. et al. The Sushi domains of GABAB receptors function as axonal targeting signals. .1  Neurosci  30, 1385-1394, doi:10.1523/JNEUROSCI.3172-09.2010 (2010). 
         110 Bony, G. et al. Non-hyperpolarizing GABAB receptor activation regulates neuronal migration and neurite growth and specification by cAMP/LKB1 . Nat Commun  4 , 1800, doi:10.1038/ncomms2820 (2013). 
         111 Priest, C. A. &amp; Puche, A. C. GABAB receptor expression and function in olfactory receptor neuron axon growth. .1  Neurobiol  60, 154-165, doi:10.1002/neu.20011 (2004). 
         112 Knudsen, C., Neyrinck, A. M., Lanthier, N. &amp; Delzenne, N. M. Microbiota and nonalcoholic fatty liver disease: promising prospects for clinical interventions?  Curr Opin  Clin  Nutr Metab  Care, doi:10.1097/MC0.0000000000000584 (2019). 
         113 Yamamoto, M., Pinto-Sanchez, M. I., Bercik, P. &amp; Britz-McKibbin, P. Metabolomics reveals elevated urinary excretion of collagen degradation and epithelial cell turnover products in irritable bowel syndrome patients. Metabolomics 15, 82, doi:10.1007/s11306-019-1543-0 (2019). 
         114 Abe, N., Borson, S. H., Gambello, M. J., Wang, F. &amp; Cavalli, V. Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves.  I Biol Chem  285, 28034-28043, doi:10.1074/jbc.M110.125336 (2010). 
         115 Zhang, J., Yang, D., Huang, H., Sun, Y. &amp; Hu, Y. Coordination of Necessary and Permissive Signals by PTEN Inhibition for CNS Axon Regeneration.  Front Neurosci  12, 558, doi:10.3389/fnins.2018.00558 (2018). 
         116 Terenzio, M. et al. Locally translated mTOR controls axonal local translation in nerve injury.  Science  359, 1416-1421, doi:10.1126/science.aan1053 (2018). 
         117 Lees, H. J., Swann, J. R., Wilson, I. D., Nicholson, J. K. &amp; Holmes, E. Hippurate: the natural history of a mammalian-microbial cometabolite. .1  Proteome Res  12, 1527-1546, doi:10.1021/pr300900b (2013). 
         118 Jung, J. Y. et al. 1H-NMR-based metabolomics study of cerebral infarction.  Stroke  42, 12821288, doi:10.1161/STROKEAHA.110.598789 (2011). 
         119 Pallister, T. et al. Hippurate as a metabolomic marker of gut microbiome diversity: Modulation by diet and relationship to metabolic syndrome.  Sci Rep  7, 13670, doi:10.1038/s41598-017-13722-4 (2017). 
         120 Mangalam, A. et al. Profile of Circulatory Metabolites in a Relapsing-remitting Animal Model of Multiple Sclerosis using Global Metabolomics.  J Clin Cell Immunol  4, doi:10.4172/2155-9899.1000150 (2013). 
       
    
     Example 5: Table 1 for Examples 1-3, Provided as Parts Tables 1A and 1B 
     Tables 1A and 1B (collectively “Table 1”) relate to genes differentially regulated in fetal brains from E14.5 offspring of SPF, ABX or Sp dams [log 2(fold change), p&lt;0.05]. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE 1A 
               
               
                   
               
               
                 gene 
                 SPF1 
                 SPF2 
                 SPF3 
                 ABX1 
                 ABX2 
                 ABχ3 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 1700017B05Rik 
                 −0.013691 
                 −0.002052 
                 0.015593 
                 0.025156 
                 0.058023 
                 0.028209 
               
               
                 1810055G02Rik 
                 −0.061343 
                 0.014947 
                 0.044343 
                 0.197809 
                 0.145103 
                 0.091112 
               
               
                 2610015P09Rik 
                 −0.011342 
                 0.011362 
                 −0.000109 
                 −0.021900 
                 −0.004519 
                 −0.017002 
               
               
                 2610020C07Rik 
                 −0.014458 
                 −0.001735 
                 0.016030 
                 0.050565 
                 0.046883 
                 0.061797 
               
               
                 2700046A07Rik 
                 −0.009163 
                 −0.004508 
                 0.013571 
                 0.023998 
                 0.044703 
                 0.049588 
               
               
                 2810408I11Rik 
                 0.007824 
                 −0.005805 
                 −0.002053 
                 −0.010604 
                 −0.013178 
                 −0.013934 
               
               
                 2810468N07Rik 
                 −0.004334 
                 0.002402 
                 0.001923 
                 −0.008982 
                 0.002462 
                 0.016393 
               
               
                 3830406C13Rik 
                 −0.001768 
                 0.000824 
                 0.000942 
                 0.044060 
                 0.044487 
                 0.034581 
               
               
                 4930447A16Rik 
                 −0.013183 
                 0.001102 
                 0.011971 
                 −0.018683 
                 −0.030010 
                 −0.023630 
               
               
                 4930511A08Rik 
                 0.000961 
                 −0.001008 
                 0.000046 
                 0.023827 
                 0.024982 
                 0.028427 
               
               
                 4933439C10Rik 
                 0.005944 
                 −0.005483 
                 −0.000484 
                 −0.035563 
                 −0.021005 
                 −0.034008 
               
               
                 5930403L14Rik 
                 −0.007801 
                 −0.012516 
                 0.020101 
                 0.009663 
                 0.040193 
                 0.038374 
               
               
                 6330415G19Rik 
                 0.023579 
                 −0.023759 
                 −0.000208 
                 −0.029023 
                 −0.023986 
                 −0.032611 
               
               
                 6330549D23Rik 
                 −0.002816 
                 0.008622 
                 −0.005846 
                 −0.000361 
                 −0.003263 
                 0.008310 
               
               
                 6430573F11Rik 
                 −0.002783 
                 0.003907 
                 −0.001133 
                 0.030136 
                 0.035753 
                 0.047103 
               
               
                 6530402F18Rik 
                 −0.009169 
                 −0.019152 
                 0.027893 
                 0.016504 
                 0.006367 
                 0.035088 
               
               
                 9130019P16Rik 
                 0.008037 
                 −0.003473 
                 −0.004598 
                 0.041812 
                 −0.004955 
                 0.026020 
               
               
                 9430065F17Rik 
                 0.006487 
                 −0.004295 
                 −0.002215 
                 0.040504 
                 0.034990 
                 0.043795 
               
               
                 A330069E16Rik 
                 0.021457 
                 0.000467 
                 −0.022255 
                 −0.039767 
                 −0.021666 
                 −0.028666 
               
               
                 A930003O13Rik 
                 0.008534 
                 −0.004075 
                 −0.004498 
                 0.031827 
                 0.020610 
                 0.015188 
               
               
                 Acad9 
                 0.014002 
                 −0.004695 
                 −0.009413 
                 0.011991 
                 −0.017004 
                 0.017679 
               
               
                 Acsbg1 
                 −0.001349 
                 0.011006 
                 −0.009733 
                 0.035657 
                 0.019684 
                 0.025965 
               
               
                 Acsf2 
                 −0.014025 
                 0.009749 
                 0.004169 
                 0.045994 
                 0.027336 
                 0.014967 
               
               
                 Adamts8 
                 −0.005227 
                 −0.004093 
                 0.009275 
                 0.038792 
                 0.005886 
                 0.003352 
               
               
                 Agap3 
                 −0.004007 
                 0.002240 
                 0.001759 
                 0.006894 
                 0.015122 
                 0.019847 
               
               
                 Airn 
                 −0.014368 
                 0.024494 
                 −0.010444 
                 0.060721 
                 0.016651 
                 −0.007511 
               
               
                 Ak7 
                 0.006079 
                 −0.015814 
                 0.009604 
                 0.026037 
                 0.027584 
                 0.033285 
               
               
                 Aldoc 
                 −0.008723 
                 0.003713 
                 0.004970 
                 0.050519 
                 0.042087 
                 0.025349 
               
               
                 Alpl 
                 −0.026255 
                 0.032967 
                 −0.007348 
                 0.063191 
                 −0.003241 
                 0.009526 
               
               
                 Ankrd11 
                 −0.007986 
                 −0.002796 
                 0.010717 
                 0.009465 
                 0.021113 
                 0.019980 
               
               
                 Ankrd6 
                 0.010002 
                 −0.008794 
                 −0.001270 
                 0.009612 
                 0.021290 
                 0.033858 
               
               
                 Ap1s1 
                 −0.005761 
                 0.004385 
                 0.001357 
                 0.011485 
                 −0.023600 
                 −0.026905 
               
               
                 Ap3s1 
                 0.026425 
                 −0.021761 
                 −0.005080 
                 −0.016582 
                 −0.033174 
                 −0.032931 
               
               
                 Arhgap10 
                 −0.010300 
                 −0.001443 
                 0.011658 
                 0.036992 
                 0.026512 
                 0.048041 
               
               
                 Arid1a 
                 −0.006357 
                 −0.013669 
                 0.019811 
                 0.013765 
                 0.017112 
                 0.037745 
               
               
                 Arl6ip1 
                 −0.005105 
                 0.005298 
                 −0.000212 
                 0.019671 
                 0.028489 
                 0.009925 
               
               
                 Armt1 
                 −0.005414 
                 0.000823 
                 0.004573 
                 −0.018029 
                 −0.007078 
                 −0.012271 
               
               
                 Arrb2 
                 0.000805 
                 0.000221 
                 −0.001027 
                 0.010841 
                 0.029075 
                 0.035742 
               
               
                 Arsa 
                 −0.013241 
                 0.014601 
                 −0.001495 
                 0.020089 
                 0.002528 
                 0.001705 
               
               
                 Arxes2 
                 0.034379 
                 −0.017030 
                 −0.017974 
                 −0.019434 
                 −0.002059 
                 0.000409 
               
               
                 Ate1 
                 0.008769 
                 −0.008560 
                 −0.000260 
                 −0.023434 
                 −0.021123 
                 −0.017943 
               
               
                 Atg4d 
                 −0.016432 
                 0.023325 
                 −0.007194 
                 0.022272 
                 0.004867 
                 0.009955 
               
               
                 Atn1 
                 −0.013192 
                 0.027587 
                 −0.014796 
                 0.035722 
                 0.022566 
                 −0.011805 
               
               
                 Atp5h 
                 0.001910 
                 −0.002401 
                 0.000488 
                 −0.020770 
                 −0.010187 
                 −0.019857 
               
               
                 Atp6ap2 
                 0.011443 
                 −0.007599 
                 −0.003915 
                 −0.028920 
                 −0.020698 
                 −0.019311 
               
               
                 Atp6v1b2 
                 0.000791 
                 −0.002553 
                 0.001759 
                 −0.018028 
                 −0.020296 
                 −0.018980 
               
               
                 Atp8b1 
                 −0.000387 
                 0.000071 
                 0.000316 
                 0.034696 
                 0.036054 
                 0.005977 
               
               
                 Atpaf1 
                 −0.000147 
                 0.005012 
                 −0.004881 
                 0.035659 
                 0.031654 
                 0.018562 
               
               
                 Atxn2 
                 0.011466 
                 −0.021734 
                 0.010024 
                 0.024880 
                 0.027287 
                 0.055831 
               
               
                 Aven 
                 −0.006599 
                 0.003708 
                 0.002868 
                 0.028375 
                 0.039584 
                 0.014862 
               
               
                 AW209491 
                 0.000205 
                 0.007619 
                 −0.007866 
                 0.037580 
                 0.045194 
                 0.032102 
               
               
                 AW549877 
                 0.026798 
                 −0.010848 
                 −0.016333 
                 −0.027213 
                 −0.008327 
                 −0.012785 
               
               
                 Axin2 
                 0.005063 
                 −0.011303 
                 0.006174 
                 0.019507 
                 0.039106 
                 0.049395 
               
               
                 B230307C23Rik 
                 0.023502 
                 −0.013659 
                 −0.010136 
                 0.018593 
                 0.011025 
                 −0.002458 
               
               
                 B3galt2 
                 0.025716 
                 −0.015715 
                 −0.010354 
                 −0.025490 
                 −0.024071 
                 −0.028417 
               
               
                 B4galt4 
                 0.000734 
                 0.000744 
                 −0.001479 
                 −0.018939 
                 −0.004451 
                 −0.045745 
               
               
                 Bahcc1 
                 −0.009021 
                 0.017805 
                 −0.008950 
                 0.033934 
                 0.040962 
                 0.048132 
               
               
                 Baiap2l1 
                 −0.006255 
                 −0.005406 
                 0.011591 
                 0.026503 
                 0.020592 
                 0.032249 
               
               
                 BC020402 
                 0.009038 
                 −0.011837 
                 0.002720 
                 −0.027330 
                 −0.042233 
                 −0.023153 
               
               
                 BC024139 
                 −0.016769 
                 0.039915 
                 −0.023999 
                 0.037852 
                 0.027411 
                 0.046107 
               
               
                 Blzf1 
                 0.005958 
                 −0.019611 
                 0.013445 
                 0.028175 
                 0.040626 
                 0.041971 
               
               
                 Bola1 
                 −0.018362 
                 0.007986 
                 0.010201 
                 0.003714 
                 0.008970 
                 0.049348 
               
               
                 Brd4 
                 0.003335 
                 −0.021785 
                 0.018168 
                 0.037761 
                 0.012085 
                 0.025806 
               
               
                 Brox 
                 0.012174 
                 0.003414 
                 −0.015729 
                 −0.026016 
                 −0.010931 
                 −0.034093 
               
               
                 C1galt1c1 
                 −0.000854 
                 0.001332 
                 −0.000478 
                 0.016391 
                 −0.015485 
                 −0.002103 
               
               
                 C1ql3 
                 −0.004347 
                 −0.002109 
                 0.006433 
                 −0.017748 
                 0.007530 
                 0.002770 
               
               
                 C330006A16Rik 
                 −0.015080 
                 0.023234 
                 −0.008445 
                 0.044709 
                 0.012585 
                 0.016892 
               
               
                 C77080 
                 −0.004162 
                 0.003333 
                 0.000819 
                 0.013053 
                 −0.006343 
                 0.031779 
               
               
                 C77370 
                 0.027254 
                 −0.013995 
                 −0.013650 
                 −0.025613 
                 −0.017690 
                 −0.037493 
               
               
                 Cadm2 
                 0.040193 
                 0.002283 
                 −0.043698 
                 −0.030855 
                 −0.021279 
                 −0.064849 
               
               
                 Camk1d 
                 0.000337 
                 −0.012317 
                 0.011879 
                 −0.015921 
                 −0.043106 
                 −0.038512 
               
               
                 Camk2d 
                 0.004607 
                 0.030487 
                 −0.035868 
                 −0.010691 
                 −0.031988 
                 −0.053633 
               
               
                 Capn3 
                 0.027683 
                 0.018873 
                 −0.047729 
                 0.014403 
                 0.043743 
                 0.075704 
               
               
                 Capns2 
                 0.004877 
                 −0.004142 
                 −0.000750 
                 0.038492 
                 −0.000046 
                 0.026689 
               
               
                 Card9 
                 −0.003258 
                 0.007833 
                 −0.004607 
                 −0.003916 
                 0.014272 
                 0.011576 
               
               
                 Carns1 
                 −0.004446 
                 0.017186 
                 −0.012907 
                 0.006516 
                 0.026279 
                 0.010374 
               
               
                 Cartpt 
                 −0.002567 
                 0.007039 
                 −0.004499 
                 0.004503 
                 −0.008416 
                 0.003896 
               
               
                 Casp9 
                 −0.014370 
                 0.008107 
                 0.006156 
                 0.015928 
                 −0.005713 
                 0.015670 
               
               
                 Casz1 
                 −0.022234 
                 0.021494 
                 0.000409 
                 0.060426 
                 0.024529 
                 0.027321 
               
               
                 Cc2d1a 
                 −0.257968 
                 0.083484 
                 0.142951 
                 0.335001 
                 0.272811 
                 0.208523 
               
               
                 Ccbl2 
                 0.003477 
                 0.003221 
                 −0.006721 
                 −0.026898 
                 −0.037175 
                 −0.014036 
               
               
                 Ccdc102a 
                 −0.031371 
                 0.017031 
                 0.013834 
                 0.035437 
                 0.051464 
                 0.014786 
               
               
                 Ccdc137 
                 0.008489 
                 −0.005540 
                 −0.002988 
                 −0.038536 
                 −0.019412 
                 −0.029305 
               
               
                 Ccdc162 
                 0.002568 
                 −0.006305 
                 0.003717 
                 0.007030 
                 0.018654 
                 0.026689 
               
               
                 Ccdc18 
                 −0.000572 
                 −0.008631 
                 0.009148 
                 −0.007838 
                 0.006226 
                 −0.032179 
               
               
                 Ccdc71l 
                 0.005088 
                 0.000476 
                 −0.005584 
                 0.022939 
                 0.031096 
                 0.004786 
               
               
                 Ccdc88b 
                 −0.011836 
                 0.001540 
                 0.010211 
                 0.017762 
                 0.017957 
                 −0.001311 
               
               
                 Ccne1 
                 0.002665 
                 −0.012001 
                 0.009254 
                 0.039234 
                 0.020589 
                 0.039957 
               
               
                 Cd34 
                 −0.003419 
                 0.006727 
                 −0.003332 
                 −0.036170 
                 −0.016832 
                 −0.025070 
               
               
                 Cdc14b 
                 0.009504 
                 −0.006412 
                 −0.003141 
                 0.006548 
                 0.013176 
                 0.040384 
               
               
                 Cdca2 
                 −0.266534 
                 0.070071 
                 0.162103 
                 0.411964 
                 0.319834 
                 0.252383 
               
               
                 Cdh20 
                 0.008465 
                 0.002678 
                 −0.011214 
                 0.020026 
                 0.032882 
                 0.042300 
               
               
                 Cdh24 
                 −0.017059 
                 −0.005905 
                 0.022672 
                 0.031148 
                 0.016972 
                 0.044253 
               
               
                 Cdk6 
                 −0.003797 
                 0.001883 
                 0.001906 
                 0.007143 
                 0.007508 
                 0.019817 
               
               
                 Cdr1 
                 −0.016600 
                 0.003017 
                 0.013422 
                 0.058517 
                 0.040913 
                 0.022276 
               
               
                 Celsr2 
                 −0.025725 
                 0.030497 
                 −0.005334 
                 0.043664 
                 0.062178 
                 0.014182 
               
               
                 Cenpb 
                 −0.017236 
                 0.007523 
                 0.009559 
                 0.014506 
                 0.021959 
                 0.032934 
               
               
                 Cep250 
                 −0.013055 
                 −0.005236 
                 0.018109 
                 0.019258 
                 0.021353 
                 0.019959 
               
               
                 Cep85l 
                 −0.003983 
                 0.012911 
                 −0.009019 
                 0.015615 
                 0.028534 
                 0.053004 
               
               
                 Cerk 
                 −0.010242 
                 0.009021 
                 0.001156 
                 0.002380 
                 0.010758 
                 0.014197 
               
               
                 Chml 
                 0.009298 
                 −0.001418 
                 −0.007932 
                 0.031669 
                 0.035364 
                 0.044170 
               
               
                 Cit 
                 −0.018667 
                 −0.016421 
                 0.034460 
                 0.021447 
                 0.019356 
                 0.055051 
               
               
                 Cklf 
                 −0.008200 
                 −0.009877 
                 0.017908 
                 −0.014710 
                 0.010322 
                 −0.015076 
               
               
                 Cks1b 
                 −0.001601 
                 0.016342 
                 −0.014911 
                 0.001054 
                 0.005292 
                 0.003786 
               
               
                 Clic3 
                 −0.005059 
                 −0.002885 
                 0.007911 
                 0.011067 
                 0.008871 
                 0.015261 
               
               
                 Clic6 
                 0.002859 
                 0.021987 
                 −0.025237 
                 −0.047145 
                 −0.018982 
                 −0.052512 
               
               
                 Clmn 
                 −0.009099 
                 −0.005537 
                 0.014523 
                 0.082723 
                 −0.002874 
                 0.014205 
               
               
                 Clock 
                 0.014457 
                 −0.002232 
                 −0.012353 
                 −0.014854 
                 −0.008199 
                 −0.024915 
               
               
                 Cmc1 
                 −0.018338 
                 −0.000061 
                 0.018168 
                 0.004406 
                 0.049142 
                 0.051443 
               
               
                 Cntnap5b 
                 −0.016586 
                 0.008286 
                 0.008158 
                 0.003131 
                 0.008968 
                 0.008780 
               
               
                 Coch 
                 −0.001445 
                 0.018071 
                 −0.016839 
                 0.026409 
                 0.030949 
                 0.038882 
               
               
                 Col7a1 
                 −0.002193 
                 −0.002355 
                 0.004537 
                 0.017110 
                 0.018107 
                 0.023445 
               
               
                 Commd9 
                 −0.002758 
                 0.007875 
                 −0.005150 
                 −0.021648 
                 −0.023572 
                 −0.003816 
               
               
                 Cplx2 
                 0.017446 
                 −0.017357 
                 −0.000299 
                 0.021516 
                 0.008766 
                 0.016710 
               
               
                 Cpped1 
                 0.032194 
                 −0.005421 
                 −0.027405 
                 −0.057051 
                 −0.027413 
                 −0.015832 
               
               
                 Cramp1l 
                 −0.004812 
                 −0.012143 
                 0.016798 
                 0.019807 
                 0.017316 
                 0.035009 
               
               
                 Creb3l1 
                 0.000881 
                 −0.009094 
                 0.008160 
                 0.022693 
                 0.024629 
                 0.027213 
               
               
                 Creb5 
                 0.006540 
                 −0.017713 
                 0.011008 
                 0.000149 
                 0.012897 
                 0.039606 
               
               
                 Crebrf 
                 0.009161 
                 −0.011623 
                 0.002384 
                 −0.023723 
                 −0.019569 
                 −0.023265 
               
               
                 Cryab 
                 −0.002842 
                 0.002140 
                 0.000697 
                 0.021712 
                 0.031529 
                 0.028885 
               
               
                 Cryzl1 
                 −0.009324 
                 −0.008925 
                 0.018077 
                 0.023165 
                 0.022803 
                 0.057894 
               
               
                 Ctrl 
                 −0.017782 
                 0.017056 
                 0.000515 
                 −0.012540 
                 −0.013972 
                 −0.007952 
               
               
                 Ctsa 
                 −0.021223 
                 0.017967 
                 0.002985 
                 0.029892 
                 0.040181 
                 0.008847 
               
               
                 Ctss 
                 0.004135 
                 0.008322 
                 −0.012541 
                 0.023067 
                 0.037548 
                 0.010570 
               
               
                 Cuedc1 
                 0.004721 
                 0.008828 
                 −0.013648 
                 0.023554 
                 0.031999 
                 0.025011 
               
               
                 Cyb561 
                 −0.025178 
                 0.009752 
                 0.015095 
                 −0.008772 
                 −0.042851 
                 −0.036849 
               
               
                 Cyb5a 
                 0.008189 
                 0.004498 
                 −0.012774 
                 0.039605 
                 0.030557 
                 0.008247 
               
               
                 Cycs 
                 −0.008731 
                 0.004820 
                 0.003872 
                 0.019464 
                 0.029763 
                 0.038929 
               
               
                 Cyp27b1 
                 −0.009895 
                 0.016250 
                 −0.006495 
                 0.005391 
                 0.032703 
                 0.031313 
               
               
                 D030068K23Rik 
                 0.014014 
                 −0.006894 
                 −0.007222 
                 0.014070 
                 0.008443 
                 0.025314 
               
               
                 D11Wsu47e 
                 0.016323 
                 −0.014643 
                 −0.001848 
                 0.026474 
                 0.015762 
                 0.009628 
               
               
                 Dbx2 
                 −0.009244 
                 0.022217 
                 −0.013236 
                 −0.000435 
                 0.030839 
                 0.016024 
               
               
                 Ddx25 
                 −0.020833 
                 0.014566 
                 0.006031 
                 0.044811 
                 0.051798 
                 0.024080 
               
               
                 Ddx27 
                 −0.002956 
                 0.005537 
                 −0.002596 
                 0.030404 
                 0.034883 
                 0.032498 
               
               
                 Deb1 
                 −0.001152 
                 −0.011867 
                 0.012911 
                 −0.019768 
                 −0.032047 
                 −0.030629 
               
               
                 Dennd1c 
                 0.000212 
                 −0.002196 
                 0.001981 
                 0.006279 
                 −0.004790 
                 0.005813 
               
               
                 Dennd2a 
                 −0.014606 
                 0.001585 
                 0.012888 
                 0.018377 
                 0.020808 
                 0.029888 
               
               
                 Dimt1 
                 0.013622 
                 −0.006121 
                 −0.007598 
                 −0.020443 
                 −0.019826 
                 −0.010126 
               
               
                 Dio3os 
                 −0.012568 
                 −0.002213 
                 0.014650 
                 −0.033654 
                 −0.031932 
                 −0.025854 
               
               
                 Dlx5 
                 −0.014187 
                 0.002352 
                 0.011716 
                 0.024353 
                 0.034172 
                 0.027894 
               
               
                 Dmd 
                 0.001628 
                 0.005958 
                 −0.007619 
                 0.031223 
                 0.015562 
                 0.012080 
               
               
                 Dnaaf2 
                 −0.001262 
                 −0.013143 
                 0.014274 
                 0.023126 
                 0.038542 
                 0.027179 
               
               
                 Dnah8 
                 −0.008404 
                 0.023940 
                 −0.015847 
                 −0.016825 
                 −0.037441 
                 −0.047572 
               
               
                 Dnase1 
                 −0.008909 
                 −0.006020 
                 0.014812 
                 0.041121 
                 0.026113 
                 0.026609 
               
               
                 Dok2 
                 −0.013260 
                 0.004552 
                 0.008614 
                 0.037157 
                 0.033690 
                 0.013780 
               
               
                 Dpp10 
                 0.019643 
                 −0.002160 
                 −0.017727 
                 −0.029691 
                 −0.032823 
                 −0.036993 
               
               
                 Dpy19l3 
                 0.009264 
                 −0.018870 
                 0.009422 
                 −0.049102 
                 −0.026817 
                 −0.012825 
               
               
                 E130012A19Rik 
                 −0.000807 
                 0.000399 
                 0.000407 
                 0.005042 
                 0.029057 
                 0.041743 
               
               
                 E130307A14Rik 
                 0.007925 
                 −0.013096 
                 0.005081 
                 0.009247 
                 0.006031 
                 0.007514 
               
               
                 E2f8 
                 0.004428 
                 −0.003275 
                 −0.001165 
                 0.005423 
                 0.044469 
                 0.036104 
               
               
                 Ece1 
                 −0.009918 
                 −0.009007 
                 0.018741 
                 0.049753 
                 0.025776 
                 0.016607 
               
               
                 Efhb 
                 −0.024910 
                 0.013484 
                 0.011106 
                 0.000963 
                 0.007163 
                 0.031476 
               
               
                 Elk4 
                 0.002294 
                 0.009720 
                 −0.012100 
                 0.032681 
                 0.027819 
                 0.031420 
               
               
                 Emp2 
                 0.017869 
                 −0.025995 
                 0.007762 
                 0.051533 
                 0.021452 
                 0.042750 
               
               
                 En2 
                 −0.000753 
                 −0.006176 
                 0.006898 
                 0.019659 
                 0.023398 
                 0.034555 
               
               
                 Epas1 
                 −0.024938 
                 0.022076 
                 0.002475 
                 0.021593 
                 0.030437 
                 0.036091 
               
               
                 Ephb2 
                 −0.015079 
                 −0.004089 
                 0.018958 
                 0.009054 
                 0.022220 
                 0.034428 
               
               
                 Epor 
                 −0.019207 
                 −0.003296 
                 0.022200 
                 0.036909 
                 0.025510 
                 0.048726 
               
               
                 Erbb2 
                 −0.018271 
                 0.015545 
                 0.002525 
                 0.044054 
                 0.015948 
                 0.011309 
               
               
                 Esd 
                 −0.004985 
                 0.002110 
                 0.002862 
                 −0.025372 
                 −0.028868 
                 −0.009583 
               
               
                 Exo5 
                 0.007018 
                 −0.010454 
                 0.003377 
                 −0.034123 
                 −0.001907 
                 −0.009558 
               
               
                 Exph5 
                 0.004080 
                 0.006158 
                 −0.010294 
                 0.062642 
                 0.020350 
                 0.009826 
               
               
                 F11r 
                 −0.016389 
                 0.009750 
                 0.006498 
                 0.046693 
                 0.031773 
                 0.016056 
               
               
                 F8 
                 0.007068 
                 0.005149 
                 −0.012296 
                 −0.011191 
                 −0.040813 
                 −0.050165 
               
               
                 Fah 
                 0.009051 
                 −0.004302 
                 −0.004792 
                 −0.012398 
                 −0.032889 
                 −0.038826 
               
               
                 Fam122b 
                 −0.008536 
                 0.009272 
                 −0.000791 
                 0.014354 
                 −0.016323 
                 −0.015643 
               
               
                 Fam126a 
                 0.008034 
                 −0.006720 
                 −0.001353 
                 −0.008075 
                 −0.012619 
                 0.000457 
               
               
                 Fam160b2 
                 −0.008582 
                 0.008630 
                 −0.000100 
                 0.022511 
                 −0.003434 
                 0.006279 
               
               
                 Fam199x 
                 0.023852 
                 0.003553 
                 −0.027875 
                 −0.004559 
                 −0.010494 
                 −0.045552 
               
               
                 Fam19a1 
                 −0.030689 
                 0.011926 
                 0.018274 
                 0.041559 
                 0.028945 
                 0.054458 
               
               
                 Fam207a 
                 −0.006397 
                 0.005546 
                 0.000825 
                 −0.021166 
                 −0.014093 
                 0.000665 
               
               
                 Fam208a 
                 −0.020957 
                 −0.007026 
                 0.027550 
                 0.040359 
                 0.027260 
                 0.034140 
               
               
                 Fam20a 
                 0.002328 
                 0.002379 
                 −0.004718 
                 0.005715 
                 0.021642 
                 0.020349 
               
               
                 Fam43b 
                 −0.010221 
                 −0.010278 
                 0.020284 
                 0.027201 
                 0.025763 
                 0.044832 
               
               
                 Fam76b 
                 −0.000292 
                 0.011086 
                 −0.010878 
                 0.019934 
                 −0.016597 
                 0.014410 
               
               
                 Fgf1 
                 −0.010076 
                 0.026548 
                 −0.016851 
                 −0.030351 
                 −0.016212 
                 −0.028811 
               
               
                 Fkbp1b 
                 −0.004434 
                 0.005703 
                 −0.001288 
                 0.119524 
                 0.006504 
                 0.007270 
               
               
                 Fndc3c1 
                 −0.000850 
                 −0.005531 
                 0.006357 
                 0.012678 
                 −0.002435 
                 −0.001269 
               
               
                 Fndc5 
                 0.013699 
                 0.007673 
                 −0.021619 
                 0.045342 
                 0.013837 
                 −0.003374 
               
               
                 Foxn2 
                 0.040966 
                 −0.015444 
                 −0.026432 
                 −0.001597 
                 −0.018413 
                 −0.006774 
               
               
                 Frem3 
                 0.006236 
                 −0.004570 
                 −0.001688 
                 0.002182 
                 0.012172 
                 0.042928 
               
               
                 Fuk 
                 −0.007673 
                 −0.001861 
                 0.009481 
                 0.018893 
                 0.028899 
                 0.028713 
               
               
                 Fut9 
                 0.037894 
                 −0.018821 
                 −0.019834 
                 −0.034702 
                 −0.014858 
                 −0.029450 
               
               
                 Gabra2 
                 −0.012137 
                 0.020750 
                 −0.008840 
                 0.038159 
                 0.027390 
                 0.032088 
               
               
                 Gabra4 
                 0.027922 
                 −0.033223 
                 0.004643 
                 −0.031251 
                 −0.057597 
                 −0.027506 
               
               
                 Gabrg1 
                 −0.022641 
                 −0.006214 
                 0.028384 
                 0.016926 
                 0.030820 
                 0.053906 
               
               
                 Gabrg2 
                 −0.006649 
                 −0.000634 
                 0.007249 
                 0.017533 
                 0.031502 
                 0.029195 
               
               
                 Gale 
                 −0.007989 
                 0.014799 
                 −0.006925 
                 −0.009497 
                 0.017537 
                 0.006901 
               
               
                 Galntl6 
                 0.003718 
                 −0.000059 
                 −0.003669 
                 0.034606 
                 0.010471 
                 0.015599 
               
               
                 Gas2l1 
                 −0.006452 
                 0.003168 
                 0.003262 
                 0.021277 
                 0.030483 
                 −0.008577 
               
               
                 Gcc1 
                 0.007802 
                 −0.013064 
                 0.005172 
                 0.023867 
                 0.030108 
                 0.025183 
               
               
                 Gcnt1 
                 −0.023484 
                 0.001719 
                 0.021414 
                 −0.021974 
                 −0.031170 
                 −0.041239 
               
               
                 Gemin4 
                 −0.016717 
                 0.005171 
                 0.011395 
                 0.036510 
                 0.027933 
                 0.024970 
               
               
                 Glg1 
                 0.008494 
                 −0.010990 
                 0.002427 
                 0.037385 
                 0.000554 
                 0.010301 
               
               
                 Gli1 
                 −0.005896 
                 −0.002743 
                 0.008599 
                 0.023753 
                 0.017393 
                 0.054424 
               
               
                 Glis3 
                 −0.013147 
                 0.039712 
                 −0.027435 
                 0.016750 
                 0.017155 
                 0.018998 
               
               
                 Glra2 
                 −0.016243 
                 −0.007444 
                 0.023386 
                 0.051520 
                 0.006376 
                 0.004759 
               
               
                 Gm11346 
                 0.000188 
                 0.008639 
                 −0.008881 
                 0.032643 
                 0.007474 
                 −0.002293 
               
               
                 Gm11974 
                 −0.011616 
                 −0.005927 
                 0.017378 
                 0.025509 
                 0.020509 
                 −0.015357 
               
               
                 Gm14164 
                 −0.011594 
                 0.012996 
                 −0.001507 
                 0.022174 
                 0.023665 
                 0.019001 
               
               
                 Gm15880 
                 0.005391 
                 0.010988 
                 −0.016525 
                 −0.027724 
                 −0.027951 
                 −0.030568 
               
               
                 Gm16740 
                 0.001744 
                 −0.005880 
                 0.004117 
                 0.015317 
                 0.012325 
                 0.021215 
               
               
                 Gm17750 
                 −0.030053 
                 0.011486 
                 0.018096 
                 0.061282 
                 0.042948 
                 0.016125 
               
               
                 Gm17769 
                 −0.002742 
                 −0.004903 
                 0.007614 
                 0.014283 
                 0.019365 
                 0.019778 
               
               
                 Gm20324 
                 −0.003894 
                 0.000389 
                 0.003495 
                 0.031336 
                 0.024251 
                 0.037550 
               
               
                 Gm6981 
                 0.003595 
                 −0.003087 
                 −0.000515 
                 0.009235 
                 0.021544 
                 0.013821 
               
               
                 Gm7173 
                 0.023755 
                 −0.003202 
                 −0.020903 
                 −0.034955 
                 −0.032778 
                 −0.024608 
               
               
                 Gpatch1 
                 0.009433 
                 −0.006669 
                 −0.002813 
                 0.276563 
                 −0.004951 
                 0.271455 
               
               
                 Gpm6a 
                 0.029635 
                 −0.017120 
                 −0.012981 
                 −0.021001 
                 −0.014083 
                 −0.030517 
               
               
                 Gpr137 
                 −0.003506 
                 0.016493 
                 −0.013146 
                 0.028135 
                 0.054863 
                 0.017631 
               
               
                 Gps2 
                 −0.004506 
                 0.003335 
                 0.001160 
                 0.009569 
                 0.006660 
                 0.012407 
               
               
                 Grhl3 
                 −0.026228 
                 0.013782 
                 0.012092 
                 0.018489 
                 0.036071 
                 0.048555 
               
               
                 Gria1 
                 0.022711 
                 −0.017778 
                 −0.005231 
                 −0.027065 
                 −0.034088 
                 −0.027728 
               
               
                 Grik4 
                 −0.007499 
                 0.015619 
                 −0.008249 
                 0.018959 
                 0.011380 
                 0.004104 
               
               
                 Grin1 
                 −0.002179 
                 0.013335 
                 −0.011264 
                 0.006259 
                 0.074773 
                 0.024808 
               
               
                 Gsr 
                 −0.000673 
                 −0.000140 
                 0.000813 
                 0.004357 
                 0.034764 
                 0.025348 
               
               
                 Gsta4 
                 −0.018132 
                 0.007389 
                 0.010572 
                 0.027919 
                 0.025005 
                 0.033530 
               
               
                 Gstm6 
                 −0.005456 
                 −0.001919 
                 0.007345 
                 0.028025 
                 0.030047 
                 0.023084 
               
               
                 Gtf3c3 
                 0.011578 
                 −0.002246 
                 −0.009411 
                 0.018668 
                 0.009081 
                 −0.005064 
               
               
                 Gucy1b3 
                 0.016377 
                 0.008318 
                 −0.025028 
                 −0.028804 
                 −0.016967 
                 −0.031624 
               
               
                 Hcn4 
                 −0.018446 
                 0.011088 
                 0.007180 
                 0.017274 
                 0.017466 
                 0.051995 
               
               
                 Hdgf 
                 −0.000720 
                 −0.009349 
                 0.010004 
                 0.028164 
                 0.023238 
                 0.010883 
               
               
                 Hebp2 
                 −0.011866 
                 −0.004097 
                 0.015822 
                 −0.022133 
                 −0.011312 
                 −0.029528 
               
               
                 Heca 
                 0.017557 
                 −0.001909 
                 −0.015842 
                 0.038117 
                 0.021492 
                 0.009732 
               
               
                 Hist1h2bg 
                 0.000117 
                 −0.005956 
                 0.005815 
                 0.002649 
                 0.006984 
                 0.043465 
               
               
                 Hist1h4b 
                 −0.017282 
                 −0.004497 
                 0.021508 
                 0.024550 
                 0.021334 
                 0.042603 
               
               
                 Hist2h3b 
                 −0.013489 
                 −0.005956 
                 0.019241 
                 0.031055 
                 0.060190 
                 0.007006 
               
               
                 Hmgb1 
                 0.024149 
                 −0.018646 
                 −0.005838 
                 −0.013967 
                 0.003214 
                 −0.000944 
               
               
                 Hnrnph2 
                 0.010933 
                 −0.003525 
                 −0.007472 
                 −0.007997 
                 −0.006749 
                 −0.016987 
               
               
                 Hpca 
                 −0.002052 
                 0.019062 
                 −0.017241 
                 −0.027830 
                 −0.022917 
                 −0.051506 
               
               
                 Hs6st2 
                 0.021908 
                 −0.003338 
                 −0.018863 
                 −0.032517 
                 −0.017529 
                 −0.029308 
               
               
                 Hsd3b6 
                 0.004440 
                 −0.006236 
                 0.001774 
                 0.010785 
                 0.013232 
                 0.015326 
               
               
                 Htr2c 
                 0.000032 
                 0.001532 
                 −0.001566 
                 0.027368 
                 0.047326 
                 0.034566 
               
               
                 ICa1 
                 0.004933 
                 0.008384 
                 −0.013412 
                 −0.030380 
                 −0.018243 
                 −0.049227 
               
               
                 Il1rap 
                 0.003743 
                 −0.001886 
                 −0.001865 
                 0.028159 
                 0.025304 
                 0.029632 
               
               
                 Inpp5f 
                 0.017837 
                 −0.001651 
                 −0.016390 
                 −0.016983 
                 −0.021727 
                 −0.019904 
               
               
                 Iqcb1 
                 0.019984 
                 −0.001183 
                 −0.019065 
                 −0.034960 
                 −0.009793 
                 −0.004832 
               
               
                 Irs1 
                 −0.002404 
                 −0.004789 
                 0.007164 
                 0.017327 
                 0.010217 
                 0.023965 
               
               
                 Irs4 
                 0.003252 
                 0.021427 
                 −0.025059 
                 0.048015 
                 0.049916 
                 0.028053 
               
               
                 Irx2 
                 −0.011814 
                 0.010835 
                 0.000889 
                 0.034875 
                 0.024138 
                 0.018274 
               
               
                 Ism1 
                 −0.002012 
                 0.003227 
                 −0.001221 
                 0.028359 
                 0.017715 
                 0.024066 
               
               
                 Itga1 
                 0.006588 
                 −0.019118 
                 0.012336 
                 −0.029112 
                 −0.004857 
                 −0.025854 
               
               
                 Jak2 
                 0.022039 
                 −0.010863 
                 −0.011432 
                 −0.014345 
                 −0.017060 
                 −0.030606 
               
               
                 Kank2 
                 −0.031797 
                 0.030973 
                 0.000141 
                 0.054543 
                 0.033444 
                 0.018352 
               
               
                 Kcnd1 
                 0.003423 
                 −0.002401 
                 −0.001028 
                 0.005455 
                 0.014243 
                 0.036797 
               
               
                 Kcnh2 
                 −0.015605 
                 0.000170 
                 0.015270 
                 0.030850 
                 0.028812 
                 0.043416 
               
               
                 Kctd5 
                 −0.018456 
                 −0.005896 
                 0.024021 
                 0.026000 
                 0.026669 
                 0.037530 
               
               
                 Kdm1b 
                 0.023451 
                 −0.025446 
                 0.001580 
                 −0.037429 
                 −0.014961 
                 −0.033708 
               
               
                 Khk 
                 −0.000828 
                 0.000802 
                 0.000026 
                 0.023286 
                 0.028787 
                 0.028469 
               
               
                 Kif27 
                 −0.007329 
                 −0.000466 
                 0.007756 
                 0.030706 
                 0.017263 
                 0.010164 
               
               
                 Kiss1r 
                 −0.014366 
                 0.005794 
                 0.008464 
                 0.017392 
                 0.014083 
                 0.026831 
               
               
                 Kitl 
                 0.043310 
                 −0.028800 
                 −0.015535 
                 −0.015555 
                 −0.035147 
                 −0.038968 
               
               
                 Kmt2d 
                 0.022014 
                 −0.037309 
                 0.014575 
                 −0.011650 
                 −0.013011 
                 0.031589 
               
               
                 Knstrn 
                 −0.003808 
                 −0.012292 
                 0.015954 
                 −0.030941 
                 −0.016816 
                 −0.020409 
               
               
                 Kri1 
                 −0.009467 
                 0.000410 
                 0.008997 
                 0.042767 
                 0.024702 
                 0.004916 
               
               
                 Lama5 
                 −0.012741 
                 −0.000298 
                 0.012925 
                 0.042904 
                 0.024527 
                 0.022320 
               
               
                 Lamtor5 
                 0.023062 
                 −0.010714 
                 −0.012627 
                 −0.029369 
                 −0.015333 
                 −0.018669 
               
               
                 Lars2 
                 −0.009459 
                 0.000777 
                 0.008625 
                 0.035127 
                 0.015773 
                 0.014660 
               
               
                 Lbh 
                 −0.009505 
                 0.005817 
                 0.003640 
                 0.007157 
                 0.008740 
                 0.022590 
               
               
                 Lingo1 
                 0.002140 
                 0.011866 
                 −0.014125 
                 0.009461 
                 0.017063 
                 0.017708 
               
               
                 Lipt2 
                 0.010499 
                 0.009588 
                 −0.020299 
                 −0.018888 
                 −0.028080 
                 −0.035831 
               
               
                 Lmx1b 
                 −0.017149 
                 0.032330 
                 −0.015732 
                 −0.020461 
                 −0.023881 
                 −0.036729 
               
               
                 LOC100862268 
                 0.009827 
                 −0.002010 
                 −0.007874 
                 −0.044395 
                 −0.032873 
                 −0.014472 
               
               
                 Loxl2 
                 −0.016265 
                 0.043373 
                 −0.028131 
                 0.085802 
                 0.036707 
                 0.017138 
               
               
                 Lpcat1 
                 −0.006534 
                 0.003221 
                 0.003291 
                 0.001024 
                 0.010501 
                 0.002687 
               
               
                 Lppr4 
                 −0.005162 
                 0.004518 
                 0.000627 
                 0.041989 
                 0.029693 
                 0.018026 
               
               
                 Lrfn1 
                 −0.009936 
                 0.020630 
                 −0.010918 
                 0.052619 
                 0.028086 
                 −0.014969 
               
               
                 Lrp1b 
                 0.026165 
                 −0.004242 
                 −0.022340 
                 0.021101 
                 0.023812 
                 0.003189 
               
               
                 Lrp5 
                 −0.018291 
                 0.007110 
                 0.011006 
                 0.043552 
                 0.054254 
                 −0.003701 
               
               
                 Lrr1 
                 −0.021191 
                 0.002217 
                 0.018696 
                 0.020177 
                 0.020899 
                 0.022818 
               
               
                 Lrrc29 
                 0.005285 
                 −0.011797 
                 0.006439 
                 0.041038 
                 −0.007727 
                 0.003862 
               
               
                 Lsm12 
                 0.000810 
                 −0.005931 
                 0.005100 
                 −0.005960 
                 0.027091 
                 0.003818 
               
               
                 Magel2 
                 −0.003451 
                 −0.002270 
                 0.005704 
                 0.028603 
                 0.011827 
                 0.017125 
               
               
                 Map1a 
                 −0.020664 
                 0.001537 
                 0.018856 
                 0.021269 
                 0.028047 
                 0.035120 
               
               
                 Map3k14 
                 −0.032854 
                 0.006272 
                 0.025962 
                 −0.012985 
                 0.026582 
                 −0.001720 
               
               
                 Map3k19 
                 −0.008404 
                 −0.004815 
                 0.013126 
                 0.057283 
                 0.020289 
                 0.022257 
               
               
                 Map3k5 
                 −0.081534 
                 0.147625 
                 −0.078253 
                 0.053402 
                 0.108373 
                 −0.079263 
               
               
                 Map7d1 
                 −0.018393 
                 0.004044 
                 0.014156 
                 0.023904 
                 0.022336 
                 0.016662 
               
               
                 Mapk8 
                 0.017699 
                 −0.014199 
                 −0.003683 
                 −0.016678 
                 −0.025807 
                 −0.023579 
               
               
                 Mapkapk2 
                 −0.019839 
                 0.009033 
                 0.010602 
                 0.028023 
                 0.016046 
                 0.036993 
               
               
                 Maz 
                 −0.016298 
                 −0.001251 
                 0.017351 
                 0.015865 
                 0.024987 
                 0.027710 
               
               
                 Mcc 
                 −0.014304 
                 0.000542 
                 0.013627 
                 0.067357 
                 0.007270 
                 0.021967 
               
               
                 Mcfd2 
                 0.000426 
                 0.009580 
                 −0.010072 
                 −0.002821 
                 −0.020723 
                 −0.020233 
               
               
                 Mdc1 
                 −0.030340 
                 0.001336 
                 0.028405 
                 0.048642 
                 0.041175 
                 0.034226 
               
               
                 Med10 
                 0.009287 
                 −0.008403 
                 −0.000939 
                 −0.022674 
                 −0.021754 
                 −0.024607 
               
               
                 Mier2 
                 −0.008238 
                 0.008359 
                 −0.000169 
                 0.012308 
                 0.019737 
                 0.053714 
               
               
                 Mier3 
                 0.020612 
                 −0.000336 
                 −0.020570 
                 −0.013814 
                 −0.019443 
                 −0.029076 
               
               
                 Mir3081 
                 0.000351 
                 −0.009182 
                 0.008775 
                 0.010811 
                 0.005576 
                 0.035663 
               
               
                 Mir411 
                 0.006437 
                 0.003800 
                 −0.010294 
                 0.019085 
                 0.013746 
                 0.025397 
               
               
                 Mir6236 
                 −0.013751 
                 0.005090 
                 0.008561 
                 0.076410 
                 0.032753 
                 −0.000536 
               
               
                 Mir6353 
                 0.003664 
                 −0.002011 
                 −0.001660 
                 −0.005129 
                 0.046421 
                 0.037742 
               
               
                 Mllt6 
                 0.011340 
                 −0.008914 
                 −0.002500 
                 0.005730 
                 0.020099 
                 0.026116 
               
               
                 Mpeg1 
                 −0.024779 
                 0.038005 
                 −0.014010 
                 0.011250 
                 0.034966 
                 0.025008 
               
               
                 Mpnd 
                 0.010233 
                 0.007810 
                 −0.018215 
                 −0.013031 
                 −0.032260 
                 −0.013999 
               
               
                 Mrpl22 
                 0.009821 
                 −0.002185 
                 −0.007692 
                 −0.004029 
                 −0.016490 
                 −0.021003 
               
               
                 Mrps18b 
                 −0.002930 
                 −0.007410 
                 0.010281 
                 −0.016610 
                 −0.029240 
                 −0.028656 
               
               
                 Mrps33 
                 0.012591 
                 −0.011405 
                 −0.001286 
                 −0.019534 
                 −0.015692 
                 −0.002915 
               
               
                 Mtcl1 
                 −0.017168 
                 0.013297 
                 0.003703 
                 0.020775 
                 0.022441 
                 0.021541 
               
               
                 Mttp 
                 0.002595 
                 0.003111 
                 −0.005723 
                 −0.017351 
                 −0.019059 
                 −0.046066 
               
               
                 Mtx3 
                 0.013996 
                 −0.007548 
                 −0.006551 
                 −0.010210 
                 −0.011360 
                 −0.014171 
               
               
                 Mum1 
                 0.007587 
                 0.006498 
                 −0.014189 
                 0.009866 
                 −0.003450 
                 −0.009214 
               
               
                 Mvk 
                 −0.000333 
                 −0.003340 
                 0.003664 
                 −0.001120 
                 0.008702 
                 0.005543 
               
               
                 Myh14 
                 −0.008945 
                 0.002133 
                 0.006766 
                 0.082437 
                 0.007931 
                 0.003062 
               
               
                 Myo5b 
                 −0.004927 
                 0.011230 
                 −0.006369 
                 0.048034 
                 0.001301 
                 −0.006029 
               
               
                 Myo6 
                 −0.007993 
                 0.003364 
                 0.004596 
                 0.021841 
                 −0.007853 
                 −0.022369 
               
               
                 Mzf1 
                 −0.017218 
                 0.001290 
                 0.015739 
                 −0.018263 
                 −0.023176 
                 −0.011228 
               
               
                 Nans 
                 0.000711 
                 0.001281 
                 −0.001995 
                 −0.034288 
                 0.001118 
                 −0.018664 
               
               
                 Nap1l5 
                 0.006232 
                 −0.008835 
                 0.002560 
                 −0.033905 
                 −0.043003 
                 −0.046929 
               
               
                 Ncmap 
                 −0.003776 
                 0.015359 
                 −0.011718 
                 0.025284 
                 0.005807 
                 0.024104 
               
               
                 Ncor2 
                 −0.015291 
                 0.028574 
                 −0.013713 
                 −0.024608 
                 −0.030869 
                 −0.007514 
               
               
                 Ndufs4 
                 0.011829 
                 −0.009173 
                 −0.002736 
                 −0.031533 
                 −0.020066 
                 −0.015932 
               
               
                 Necab1 
                 0.008373 
                 −0.000349 
                 −0.008070 
                 −0.031710 
                 −0.029761 
                 −0.041638 
               
               
                 Nek11 
                 −0.002918 
                 −0.011713 
                 0.014507 
                 −0.007641 
                 −0.025728 
                 −0.009841 
               
               
                 Nexn 
                 0.028425 
                 −0.004457 
                 −0.024463 
                 −0.018251 
                 −0.010557 
                 −0.010331 
               
               
                 Nfs1 
                 −0.002135 
                 −0.006732 
                 0.008823 
                 −0.034498 
                 −0.025832 
                 −0.026292 
               
               
                 Nipa2 
                 0.013274 
                 −0.015719 
                 0.002297 
                 −0.039300 
                 −0.012938 
                 −0.031812 
               
               
                 Nipal2 
                 −0.014130 
                 0.005121 
                 0.008903 
                 −0.020718 
                 −0.034423 
                 −0.030661 
               
               
                 Nmd3 
                 0.017927 
                 −0.005239 
                 −0.012867 
                 −0.020403 
                 −0.024094 
                 −0.037752 
               
               
                 Nol4 
                 0.016709 
                 −0.018429 
                 0.001505 
                 −0.041465 
                 −0.012868 
                 −0.014388 
               
               
                 Notch3 
                 −0.040705 
                 0.008761 
                 0.031013 
                 0.028291 
                 0.041644 
                 0.044335 
               
               
                 Nptxr 
                 −0.003279 
                 0.006671 
                 −0.003415 
                 0.031615 
                 0.017866 
                 0.024378 
               
               
                 Npy1r 
                 0.001244 
                 0.011105 
                 −0.012445 
                 0.037032 
                 0.018236 
                 −0.030671 
               
               
                 Nr5a2 
                 0.009878 
                 0.005378 
                 −0.015382 
                 −0.004256 
                 −0.006021 
                 0.002077 
               
               
                 Nrcam 
                 0.012295 
                 −0.006825 
                 −0.005549 
                 0.009287 
                 0.011469 
                 0.003472 
               
               
                 Nsun6 
                 0.020092 
                 −0.009873 
                 −0.010431 
                 −0.030156 
                 −0.021543 
                 −0.029621 
               
               
                 Ntn1 
                 0.005978 
                 −0.001328 
                 −0.004671 
                 −0.028408 
                 −0.019801 
                 −0.035034 
               
               
                 Ntng1 
                 0.021517 
                 0.009888 
                 −0.031951 
                 −0.029923 
                 −0.039840 
                 −0.032436 
               
               
                 Nudt11 
                 −0.004422 
                 −0.014007 
                 0.018239 
                 0.007596 
                 −0.004717 
                 −0.003711 
               
               
                 Nup214 
                 0.017379 
                 0.013747 
                 −0.031641 
                 −0.041918 
                 −0.047491 
                 −0.043206 
               
               
                 Oxsm 
                 0.004297 
                 −0.011414 
                 0.007048 
                 0.001348 
                 0.024905 
                 0.025040 
               
               
                 Pcdh20 
                 0.023639 
                 −0.001203 
                 −0.022811 
                 −0.026525 
                 −0.038849 
                 −0.038645 
               
               
                 Pcdh7 
                 0.003534 
                 0.011239 
                 −0.014898 
                 −0.010953 
                 −0.019754 
                 −0.035595 
               
               
                 Pcdha11 
                 −0.022670 
                 0.006607 
                 0.015785 
                 −0.010027 
                 −0.044659 
                 −0.044411 
               
               
                 Pcdha7-g 
                 −0.010005 
                 −0.006479 
                 0.016342 
                 −0.034866 
                 −0.006901 
                 −0.025434 
               
               
                 Pcdhb12 
                 −0.012498 
                 0.006894 
                 0.005523 
                 −0.027142 
                 −0.044063 
                 −0.026985 
               
               
                 Pcdhb20 
                 0.018064 
                 0.000261 
                 −0.018557 
                 −0.025144 
                 −0.023118 
                 −0.031505 
               
               
                 Pcdhb22 
                 −0.011889 
                 0.008329 
                 0.003484 
                 −0.035698 
                 −0.027813 
                 −0.037372 
               
               
                 Pcdhgb5 
                 −0.003894 
                 −0.009070 
                 0.012872 
                 −0.039541 
                 −0.035397 
                 −0.050953 
               
               
                 Pde4d 
                 −0.006608 
                 0.012885 
                 −0.006364 
                 −0.044989 
                 −0.031616 
                 −0.035750 
               
               
                 Pdia4 
                 −0.006346 
                 0.001444 
                 0.004878 
                 0.033812 
                 0.031569 
                 0.002745 
               
               
                 Pdss2 
                 0.004271 
                 0.007096 
                 −0.011436 
                 0.029407 
                 0.016528 
                 0.035478 
               
               
                 Pex11b 
                 0.001524 
                 −0.000007 
                 −0.001519 
                 −0.035175 
                 −0.028986 
                 −0.013867 
               
               
                 Pgbd1 
                 0.004859 
                 0.000938 
                 −0.005818 
                 −0.022896 
                 0.001550 
                 −0.011179 
               
               
                 Phf5a 
                 0.001928 
                 −0.016349 
                 0.014257 
                 −0.031943 
                 −0.026539 
                 0.000463 
               
               
                 Phyhip 
                 0.008792 
                 0.006281 
                 −0.015192 
                 −0.017888 
                 −0.036329 
                 −0.038415 
               
               
                 Pip4k2a 
                 0.010530 
                 −0.002978 
                 −0.007615 
                 −0.013783 
                 −0.020200 
                 −0.030017 
               
               
                 Pisd-ps3 
                 −0.045314 
                 0.010817 
                 0.033364 
                 −0.003239 
                 −0.038375 
                 −0.055206 
               
               
                 Plagl2 
                 0.006606 
                 0.005413 
                 −0.012095 
                 −0.017949 
                 −0.019388 
                 −0.048270 
               
               
                 Plcd 
                 −0.007514 
                 0.019600 
                 −0.012291 
                 0.031706 
                 −0.000887 
                 0.018776 
               
               
                 Pld2 
                 0.008658 
                 0.005440 
                 −0.014205 
                 −0.037315 
                 −0.041158 
                 −0.016724 
               
               
                 Plek 
                 0.023422 
                 0.012021 
                 −0.036133 
                 −0.020604 
                 −0.009310 
                 −0.016587 
               
               
                 Plekhn1 
                 −0.018748 
                 −0.000333 
                 0.018836 
                 0.010464 
                 0.045068 
                 0.034149 
               
               
                 Plp2 
                 0.003632 
                 0.000865 
                 −0.004509 
                 −0.039208 
                 −0.068040 
                 −0.034770 
               
               
                 Plxna3 
                 0.010246 
                 0.003164 
                 −0.013512 
                 −0.020572 
                 −0.022906 
                 −0.029430 
               
               
                 Pmaip1 
                 −0.015985 
                 0.012651 
                 0.003187 
                 −0.033896 
                 −0.040987 
                 −0.031887 
               
               
                 Poli 
                 −0.008654 
                 −0.003660 
                 0.012231 
                 −0.004677 
                 −0.054700 
                 −0.033878 
               
               
                 Polr3c 
                 0.001293 
                 −0.004817 
                 0.003512 
                 −0.008154 
                 −0.017295 
                 0.011259 
               
               
                 Polr3gl 
                 −0.016605 
                 −0.000946 
                 0.017351 
                 0.011359 
                 0.014296 
                 0.008375 
               
               
                 Polrmt 
                 −0.008069 
                 0.010393 
                 −0.002386 
                 0.032318 
                 0.002574 
                 0.025351 
               
               
                 Pou2f2 
                 0.007522 
                 −0.004407 
                 −0.003144 
                 0.027385 
                 0.023020 
                 0.044023 
               
               
                 Pou6f2 
                 0.016915 
                 −0.003890 
                 −0.013190 
                 −0.038737 
                 −0.031669 
                 −0.004319 
               
               
                 Ppap2b 
                 0.003073 
                 −0.006233 
                 0.003140 
                 −0.027927 
                 −0.031911 
                 −0.038361 
               
               
                 Ppp1r3fos 
                 0.025256 
                 0.005432 
                 −0.031256 
                 0.011713 
                 −0.016233 
                 0.018778 
               
               
                 Prr12 
                 0.019562 
                 0.007179 
                 −0.027145 
                 −0.038234 
                 −0.023189 
                 −0.032791 
               
               
                 Prr36 
                 0.010415 
                 −0.017502 
                 0.006927 
                 0.013732 
                 −0.000494 
                 0.039650 
               
               
                 Prrc2a 
                 −0.022121 
                 −0.014583 
                 0.036009 
                 0.017364 
                 0.031456 
                 0.041011 
               
               
                 Prrg1 
                 0.024562 
                 −0.009391 
                 −0.015495 
                 −0.030528 
                 −0.066212 
                 −0.030298 
               
               
                 Psg16 
                 0.010298 
                 −0.002768 
                 −0.007589 
                 −0.030109 
                 −0.021847 
                 −0.067258 
               
               
                 Pstpip2 
                 −0.014425 
                 0.015278 
                 −0.001007 
                 −0.018167 
                 −0.028999 
                 −0.029915 
               
               
                 Ptch2 
                 −0.010309 
                 0.007732 
                 0.002517 
                 0.032688 
                 0.030106 
                 0.024728 
               
               
                 Ptk2b 
                 −0.022265 
                 0.013349 
                 0.008657 
                 −0.055288 
                 −0.024587 
                 −0.035177 
               
               
                 Ptprf 
                 −0.024287 
                 0.002195 
                 0.021723 
                 0.020469 
                 0.022752 
                 0.024853 
               
               
                 Pus7 
                 −0.016915 
                 0.000304 
                 0.016418 
                 −0.018272 
                 −0.034009 
                 −0.034447 
               
               
                 Pxn 
                 0.011143 
                 −0.006321 
                 −0.004887 
                 −0.018441 
                 0.002311 
                 0.002613 
               
               
                 Rapgef1 
                 −0.006112 
                 −0.015870 
                 0.021718 
                 0.022698 
                 0.017193 
                 0.035272 
               
               
                 Rcan2 
                 −0.016526 
                 0.020618 
                 −0.004340 
                 −0.023357 
                 −0.041106 
                 −0.021282 
               
               
                 Reps2 
                 0.022723 
                 −0.007819 
                 −0.015185 
                 −0.039149 
                 −0.031480 
                 −0.041976 
               
               
                 Rgs17 
                 0.012416 
                 −0.005070 
                 −0.007428 
                 −0.028242 
                 −0.043635 
                 −0.022940 
               
               
                 Rhof 
                 0.005288 
                 −0.012451 
                 0.007082 
                 −0.030062 
                 −0.034903 
                 −0.025996 
               
               
                 Ric8b 
                 0.015228 
                 −0.007809 
                 −0.007541 
                 −0.014912 
                 −0.034270 
                 −0.020248 
               
               
                 Rilpl1 
                 0.002712 
                 0.003608 
                 −0.006341 
                 −0.005501 
                 −0.007587 
                 −0.009483 
               
               
                 Rin3 
                 −0.014830 
                 0.004207 
                 0.010502 
                 0.016494 
                 0.034052 
                 0.035408 
               
               
                 Rint1 
                 0.010160 
                 −0.003744 
                 −0.006471 
                 −0.038676 
                 −0.050862 
                 −0.006302 
               
               
                 Rn45s 
                 0.012530 
                 0.006240 
                 −0.018962 
                 −0.034615 
                 −0.051512 
                 −0.018833 
               
               
                 Rnf126 
                 −0.028653 
                 0.014928 
                 0.013304 
                 0.013297 
                 0.022822 
                 0.023288 
               
               
                 Rnpep 
                 −0.007857 
                 −0.000687 
                 0.008498 
                 0.034274 
                 0.014885 
                 0.027546 
               
               
                 Rnpepl1 
                 −0.019349 
                 −0.001627 
                 0.020697 
                 0.040673 
                 0.015002 
                 0.031729 
               
               
                 Rpl19 
                 −0.009816 
                 0.005865 
                 0.003901 
                 −0.003314 
                 −0.026377 
                 −0.009122 
               
               
                 Rpl23a 
                 −0.007372 
                 −0.011625 
                 0.018808 
                 −0.010686 
                 0.007123 
                 0.001361 
               
               
                 Rpl3 
                 −0.007286 
                 0.015932 
                 −0.008780 
                 −0.002991 
                 −0.023046 
                 −0.018411 
               
               
                 Rpn2 
                 −0.012772 
                 0.012127 
                 0.000538 
                 0.040068 
                 0.020043 
                 0.007737 
               
               
                 Rps12 
                 −0.006454 
                 0.012701 
                 −0.006331 
                 −0.000015 
                 −0.018088 
                 −0.004917 
               
               
                 Rps2 
                 −0.003782 
                 −0.002971 
                 0.006730 
                 −0.003623 
                 −0.009712 
                 0.008957 
               
               
                 Rwdd2b 
                 0.010165 
                 −0.003971 
                 −0.006249 
                 −0.010412 
                 −0.037133 
                 −0.065397 
               
               
                 Rxfp3 
                 −0.012760 
                 0.021961 
                 −0.009457 
                 0.036721 
                 0.013645 
                 0.025178 
               
               
                 Ryr2 
                 0.009468 
                 0.012583 
                 −0.022309 
                 −0.038208 
                 −0.022667 
                 −0.030954 
               
               
                 S100a11 
                 0.002840 
                 0.013107 
                 −0.016099 
                 −0.006264 
                 0.004612 
                 −0.019450 
               
               
                 Sall2 
                 −0.011825 
                 0.002894 
                 0.008853 
                 0.016678 
                 0.017757 
                 0.025393 
               
               
                 Sarnp 
                 0.019599 
                 −0.029818 
                 0.009746 
                 −0.014753 
                 0.004823 
                 −0.021101 
               
               
                 Sash3 
                 0.000140 
                 −0.019687 
                 0.019285 
                 0.000651 
                 −0.035287 
                 −0.030888 
               
               
                 Scaf1 
                 −0.024879 
                 0.010482 
                 0.014076 
                 0.024125 
                 0.031139 
                 0.036283 
               
               
                 Scd4 
                 0.000404 
                 −0.001321 
                 0.000916 
                 0.039579 
                 0.005706 
                 0.029497 
               
               
                 Scn1a 
                 0.029830 
                 −0.000974 
                 −0.029465 
                 −0.030302 
                 −0.026805 
                 −0.066524 
               
               
                 Scrib 
                 −0.019934 
                 0.010178 
                 0.009551 
                 0.014896 
                 0.026881 
                 0.030888 
               
               
                 Scrt1 
                 0.001305 
                 0.010579 
                 −0.011973 
                 −0.022429 
                 −0.024621 
                 −0.024599 
               
               
                 Scube1 
                 −0.025287 
                 0.029126 
                 −0.004362 
                 −0.031709 
                 −0.034672 
                 −0.038635 
               
               
                 Scx 
                 −0.012935 
                 0.024398 
                 −0.011776 
                 −0.013270 
                 −0.029412 
                 −0.027498 
               
               
                 Sdha 
                 0.004352 
                 0.005067 
                 −0.009465 
                 −0.002049 
                 −0.011239 
                 −0.007797 
               
               
                 Sema3f 
                 0.001632 
                 −0.004266 
                 0.002624 
                 −0.025954 
                 −0.024357 
                 −0.019785 
               
               
                 Sema6a 
                 0.012876 
                 0.024367 
                 −0.038004 
                 −0.060562 
                 −0.022630 
                 −0.065122 
               
               
                 Senp7 
                 0.019679 
                 −0.011813 
                 −0.008072 
                 −0.018142 
                 −0.014763 
                 −0.039642 
               
               
                 Sfxn4 
                 0.007113 
                 −0.000770 
                 −0.006375 
                 −0.030690 
                 −0.025937 
                 −0.022274 
               
               
                 Sgk3 
                 −0.002299 
                 −0.019698 
                 0.021697 
                 −0.057281 
                 −0.023063 
                 −0.044107 
               
               
                 Sh3bgrl2 
                 −0.003420 
                 0.013913 
                 −0.010603 
                 −0.017819 
                 −0.026839 
                 −0.025606 
               
               
                 Sh3bp4 
                 −0.008671 
                 −0.002980 
                 0.011576 
                 0.033888 
                 0.030763 
                 0.018081 
               
               
                 Shisa9 
                 0.008869 
                 0.008787 
                 −0.017819 
                 −0.039235 
                 −0.030927 
                 −0.023212 
               
               
                 Shmt2 
                 −0.011753 
                 −0.026609 
                 0.037577 
                 0.039428 
                 0.032039 
                 0.030435 
               
               
                 Sigmar1 
                 0.004379 
                 −0.003622 
                 −0.000769 
                 0.022653 
                 0.023540 
                 0.038625 
               
               
                 Slc10a3 
                 0.004188 
                 −0.008621 
                 0.004395 
                 0.038554 
                 0.020932 
                 0.031304 
               
               
                 Slc15a4 
                 0.011103 
                 −0.003419 
                 −0.007752 
                 −0.037626 
                 −0.019966 
                 −0.058918 
               
               
                 Slc17a5 
                 0.019953 
                 −0.017586 
                 −0.002615 
                 −0.035722 
                 −0.024544 
                 −0.025056 
               
               
                 Slc1a5 
                 −0.013425 
                 0.006442 
                 0.006890 
                 −0.035908 
                 −0.038050 
                 −0.017909 
               
               
                 Slc22a12 
                 −0.014598 
                 0.006600 
                 0.007887 
                 0.001005 
                 −0.016955 
                 −0.002747 
               
               
                 Slc24a3 
                 −0.006701 
                 −0.011528 
                 0.018054 
                 −0.043770 
                 −0.022563 
                 −0.030934 
               
               
                 Slc25a1 
                 −0.017147 
                 0.009831 
                 0.007163 
                 0.014053 
                 0.032417 
                 0.020103 
               
               
                 Slc29a4 
                 0.016903 
                 −0.016003 
                 −0.001088 
                 0.033645 
                 0.017912 
                 0.032389 
               
               
                 Slc35f3 
                 −0.015911 
                 0.019353 
                 −0.003664 
                 0.001338 
                 −0.023620 
                 −0.000806 
               
               
                 Slc36a4 
                 0.019354 
                 0.014566 
                 −0.034534 
                 −0.035845 
                 −0.010997 
                 −0.050029 
               
               
                 Slc37a2 
                 −0.010758 
                 −0.007981 
                 0.018557 
                 0.020876 
                 0.027231 
                 0.031998 
               
               
                 Slc52a2 
                 −0.013902 
                 0.025494 
                 −0.011934 
                 0.013856 
                 0.011449 
                 0.033675 
               
               
                 Slc6a8 
                 −0.003339 
                 −0.001963 
                 0.005286 
                 0.018356 
                 0.030737 
                 0.018864 
               
               
                 Slco2b1 
                 −0.010552 
                 0.011054 
                 −0.000583 
                 0.043834 
                 0.048050 
                 0.014267 
               
               
                 Slitrk4 
                 0.007124 
                 0.014255 
                 −0.021628 
                 −0.022324 
                 −0.033070 
                 −0.034216 
               
               
                 Smarca5-ps 
                 0.005849 
                 0.009971 
                 −0.015954 
                 −0.037944 
                 −0.027329 
                 −0.024792 
               
               
                 Smim20 
                 −0.022286 
                 0.005181 
                 0.016826 
                 −0.028832 
                 −0.042365 
                 −0.016469 
               
               
                 Smim3 
                 −0.010199 
                 0.006428 
                 0.003716 
                 0.052992 
                 0.021058 
                 0.012297 
               
               
                 Smim8 
                 −0.019799 
                 0.019320 
                 0.000213 
                 −0.007489 
                 −0.007999 
                 −0.011845 
               
               
                 Smpdl3a 
                 −0.026893 
                 −0.013970 
                 0.039987 
                 −0.024862 
                 −0.022771 
                 −0.024425 
               
               
                 Snhg1 
                 −0.003079 
                 −0.011730 
                 0.014683 
                 −0.029954 
                 −0.015735 
                 0.001372 
               
               
                 Snora15 
                 0.000551 
                 −0.013847 
                 0.013169 
                 −0.038679 
                 −0.026570 
                 −0.037862 
               
               
                 Snora23 
                 0.021673 
                 −0.001825 
                 −0.020153 
                 −0.012766 
                 −0.021076 
                 −0.025328 
               
               
                 Snord91a 
                 0.002435 
                 −0.005583 
                 0.003132 
                 0.011095 
                 0.044474 
                 0.020983 
               
               
                 Socs6 
                 −0.000791 
                 0.026411 
                 −0.026097 
                 −0.027661 
                 −0.030910 
                 −0.019523 
               
               
                 Sox13 
                 0.000539 
                 0.005293 
                 −0.005853 
                 0.025914 
                 0.029097 
                 0.030091 
               
               
                 Sox4 
                 −0.001663 
                 −0.004362 
                 0.006005 
                 0.000642 
                 0.006085 
                 0.007327 
               
               
                 Spry3 
                 0.010023 
                 0.013463 
                 −0.023778 
                 0.000726 
                 0.016737 
                 −0.000700 
               
               
                 Spsb1 
                 −0.000132 
                 0.013928 
                 −0.013930 
                 −0.021138 
                 −0.020941 
                 −0.005620 
               
               
                 Sqrdl 
                 −0.004965 
                 0.003341 
                 0.001611 
                 −0.017190 
                 −0.027351 
                 −0.028406 
               
               
                 Srbd1 
                 0.000813 
                 −0.000241 
                 −0.000572 
                 −0.020799 
                 0.011609 
                 −0.020928 
               
               
                 Src 
                 −0.021455 
                 0.005947 
                 0.015256 
                 0.017420 
                 0.028482 
                 0.024690 
               
               
                 Srcap 
                 0.002458 
                 −0.015759 
                 0.013153 
                 0.014770 
                 0.014343 
                 0.026788 
               
               
                 Srp54b 
                 0.001813 
                 0.008845 
                 −0.010726 
                 −0.024740 
                 −0.020908 
                 −0.005128 
               
               
                 St3gal3 
                 −0.001947 
                 0.013125 
                 −0.011283 
                 0.023552 
                 0.019318 
                 0.034874 
               
               
                 St8sia6 
                 0.043534 
                 −0.024469 
                 −0.020073 
                 −0.043456 
                 −0.041574 
                 −0.026120 
               
               
                 Stard5 
                 −0.005244 
                 −0.006021 
                 0.011199 
                 −0.018216 
                 −0.025443 
                 −0.034054 
               
               
                 Stxbp3-ps 
                 0.011052 
                 0.009172 
                 −0.020440 
                 −0.037943 
                 −0.013422 
                 −0.040494 
               
               
                 Supt6 
                 0.003228 
                 −0.005452 
                 0.002208 
                 0.014245 
                 0.014766 
                 0.024974 
               
               
                 Sv2b 
                 0.038616 
                 −0.001189 
                 −0.038457 
                 −0.042965 
                 −0.049963 
                 −0.040797 
               
               
                 Svopl 
                 −0.015065 
                 0.015237 
                 −0.000331 
                 −0.006704 
                 0.002560 
                 −0.012317 
               
               
                 Synpo2 
                 −0.023778 
                 0.012197 
                 0.011290 
                 0.027852 
                 0.057355 
                 0.010588 
               
               
                 Syt17 
                 0.013027 
                 −0.003593 
                 −0.009529 
                 −0.036883 
                 −0.014745 
                 −0.025348 
               
               
                 Syt3 
                 −0.008239 
                 0.009751 
                 −0.001570 
                 −0.020546 
                 −0.036464 
                 −0.028218 
               
               
                 Syvn1 
                 −0.019328 
                 0.009312 
                 0.009824 
                 0.011102 
                 0.037692 
                 0.039538 
               
               
                 Tacc1 
                 −0.000906 
                 0.005976 
                 −0.005092 
                 −0.021800 
                 0.021032 
                 −0.026515 
               
               
                 Tada1 
                 0.001590 
                 −0.003640 
                 0.002043 
                 −0.034684 
                 −0.008010 
                 −0.027514 
               
               
                 Taf1a 
                 0.017011 
                 −0.005710 
                 −0.011459 
                 −0.020314 
                 −0.009568 
                 −0.020910 
               
               
                 Taf4a 
                 0.031887 
                 0.009970 
                 −0.042877 
                 −0.033405 
                 −0.042192 
                 −0.044984 
               
               
                 Taok2 
                 0.004774 
                 0.000322 
                 −0.005113 
                 0.017756 
                 0.021997 
                 0.014852 
               
               
                 Tas1r1 
                 0.001524 
                 −0.001561 
                 0.000035 
                 −0.015380 
                 −0.008555 
                 −0.003584 
               
               
                 Tatdn1 
                 −0.025233 
                 0.020336 
                 0.004527 
                 −0.031775 
                 −0.030837 
                 −0.031760 
               
               
                 Tbc1d10a 
                 −0.008675 
                 0.001772 
                 0.006860 
                 0.022187 
                 −0.001686 
                 0.006209 
               
               
                 Tbc1d4 
                 −0.009719 
                 0.003963 
                 0.005707 
                 −0.019637 
                 0.001366 
                 −0.005345 
               
               
                 Tbc1d9 
                 −0.004999 
                 0.005437 
                 −0.000457 
                 −0.001518 
                 0.017596 
                 0.007560 
               
               
                 Tbx2 
                 −0.029950 
                 0.019117 
                 0.010360 
                 0.081200 
                 0.023088 
                 0.017227 
               
               
                 Tcf3 
                 −0.030448 
                 −0.003033 
                 0.032783 
                 0.022485 
                 0.023775 
                 0.043199 
               
               
                 Tenm1 
                 0.010046 
                 0.015652 
                 −0.026052 
                 −0.023777 
                 −0.035682 
                 −0.030103 
               
               
                 Tfcp2l1 
                 0.020540 
                 −0.001251 
                 −0.019568 
                 −0.036448 
                 −0.034980 
                 −0.037405 
               
               
                 Them4 
                 0.002209 
                 0.014996 
                 −0.017390 
                 −0.025831 
                 −0.014387 
                 −0.016045 
               
               
                 Thoc7 
                 0.016809 
                 −0.017870 
                 0.000852 
                 −0.036856 
                 −0.027174 
                 −0.034740 
               
               
                 Thsd4 
                 0.006019 
                 0.005836 
                 −0.011929 
                 −0.047726 
                 −0.046408 
                 −0.006245 
               
               
                 Tigar 
                 −0.002701 
                 0.011342 
                 −0.008714 
                 0.017069 
                 0.037864 
                 0.033421 
               
               
                 Timm9 
                 −0.005605 
                 0.013310 
                 −0.007798 
                 −0.004740 
                 −0.000800 
                 0.012257 
               
               
                 Tm4sf1 
                 0.028563 
                 −0.006535 
                 −0.022502 
                 −0.015783 
                 −0.005930 
                 −0.017539 
               
               
                 Tmc7 
                 −0.006083 
                 0.004833 
                 0.001228 
                 −0.011373 
                 0.004561 
                 −0.031664 
               
               
                 Tmem170b 
                 −0.000658 
                 −0.004610 
                 0.005251 
                 −0.001248 
                 0.008376 
                 −0.007683 
               
               
                 Tmem180 
                 −0.003636 
                 −0.001435 
                 0.005057 
                 −0.042603 
                 −0.028332 
                 −0.022672 
               
               
                 Tmem185b 
                 0.011836 
                 −0.014195 
                 0.002240 
                 −0.001541 
                 −0.004751 
                 −0.012033 
               
               
                 Tmem203 
                 −0.012320 
                 0.001317 
                 0.010908 
                 −0.022027 
                 −0.025258 
                 −0.015142 
               
               
                 Tmem29 
                 0.005702 
                 −0.007076 
                 0.001345 
                 −0.014522 
                 −0.030633 
                 −0.053734 
               
               
                 Tmem81 
                 −0.021138 
                 −0.000753 
                 0.021574 
                 −0.020405 
                 −0.030635 
                 −0.031197 
               
               
                 Tmem8b 
                 −0.017438 
                 0.006082 
                 0.011195 
                 0.026036 
                 0.020533 
                 0.009567 
               
               
                 Tmem9 
                 0.009546 
                 −0.004700 
                 −0.004894 
                 −0.028288 
                 −0.032638 
                 −0.018057 
               
               
                 Tmppe 
                 −0.016695 
                 −0.004086 
                 0.020531 
                 0.021167 
                 0.022400 
                 0.031954 
               
               
                 Tnfrsf19 
                 0.006787 
                 −0.010305 
                 0.003462 
                 0.008369 
                 0.027508 
                 0.031933 
               
               
                 Tomm5 
                 0.000929 
                 0.012976 
                 −0.014031 
                 −0.017698 
                 −0.038827 
                 −0.037850 
               
               
                 Tpcn1 
                 −0.011163 
                 0.008714 
                 0.002378 
                 0.009310 
                 0.040114 
                 0.049309 
               
               
                 Trim13 
                 0.019233 
                 −0.004542 
                 −0.014903 
                 −0.029189 
                 −0.013496 
                 −0.030691 
               
               
                 Trim9 
                 0.007306 
                 −0.006910 
                 −0.000431 
                 −0.006094 
                 −0.006103 
                 −0.001308 
               
               
                 Tshz3 
                 0.002918 
                 0.015158 
                 −0.018274 
                 −0.048314 
                 −0.012300 
                 −0.039350 
               
               
                 Tspan13 
                 0.007890 
                 −0.000036 
                 −0.007897 
                 −0.006777 
                 −0.009938 
                 −0.012938 
               
               
                 Ttc39aos1 
                 −0.003346 
                 0.009217 
                 −0.005917 
                 −0.023948 
                 −0.012736 
                 −0.006059 
               
               
                 Tuft1 
                 0.001296 
                 0.001697 
                 −0.002998 
                 0.003914 
                 −0.008725 
                 0.001321 
               
               
                 Txnrd3 
                 0.003943 
                 −0.004030 
                 0.000075 
                 −0.040823 
                 −0.029196 
                 −0.022389 
               
               
                 Ubap2 
                 0.007254 
                 −0.021887 
                 0.014378 
                 0.011429 
                 0.026834 
                 0.034243 
               
               
                 Ubb 
                 0.005381 
                 −0.007630 
                 0.002217 
                 −0.023365 
                 −0.020315 
                 −0.010179 
               
               
                 Ube2j2 
                 0.008102 
                 −0.008789 
                 0.000637 
                 0.010031 
                 −0.007326 
                 −0.011033 
               
               
                 Ube2r2 
                 −0.003064 
                 −0.004666 
                 0.007698 
                 0.021720 
                 0.012959 
                 0.021269 
               
               
                 Uck2 
                 0.001256 
                 −0.007776 
                 0.006484 
                 0.023998 
                 0.030929 
                 0.022775 
               
               
                 Utp11l 
                 0.003668 
                 0.007234 
                 −0.010967 
                 −0.016373 
                 −0.014688 
                 −0.019780 
               
               
                 Vac14 
                 0.009450 
                 −0.014758 
                 0.005192 
                 0.004690 
                 0.010709 
                 0.039612 
               
               
                 Vamp7 
                 −0.007581 
                 0.009221 
                 −0.001691 
                 −0.048348 
                 −0.037779 
                 −0.013205 
               
               
                 Vangl2 
                 −0.008416 
                 −0.013115 
                 0.021290 
                 0.016466 
                 0.019586 
                 0.050076 
               
               
                 Vasp 
                 −0.026147 
                 0.013322 
                 0.012474 
                 0.032668 
                 0.028802 
                 0.036944 
               
               
                 Vcpip1 
                 0.021563 
                 −0.002627 
                 −0.019228 
                 −0.021589 
                 −0.015551 
                 −0.022061 
               
               
                 Vwa8 
                 −0.001728 
                 0.008831 
                 −0.007148 
                 0.028282 
                 0.021707 
                 0.021273 
               
               
                 Vwc2l 
                 −0.009752 
                 0.011764 
                 −0.002095 
                 −0.027229 
                 −0.022005 
                 −0.026290 
               
               
                 Wfs1 
                 0.017082 
                 0.008069 
                 −0.025499 
                 −0.028008 
                 −0.024851 
                 −0.042632 
               
               
                 Xlr3a 
                 −0.000673 
                 0.002167 
                 −0.001497 
                 −0.029158 
                 −0.021372 
                 −0.030573 
               
               
                 Xylt1 
                 0.007624 
                 0.025160 
                 −0.033409 
                 −0.031928 
                 −0.042862 
                 −0.034861 
               
               
                 Yipf2 
                 0.016655 
                 −0.004826 
                 −0.011983 
                 0.011403 
                 −0.006338 
                 0.034880 
               
               
                 Zbtb45 
                 0.018195 
                 −0.004690 
                 −0.013692 
                 −0.036749 
                 −0.026237 
                 −0.029094 
               
               
                 Zbtb46 
                 0.023025 
                 0.001658 
                 −0.025086 
                 −0.023924 
                 −0.033067 
                 −0.041451 
               
               
                 Zc3h10 
                 0.011316 
                 −0.015060 
                 0.003617 
                 −0.008523 
                 −0.023412 
                 −0.002397 
               
               
                 Zc3h12b 
                 0.008060 
                 0.015084 
                 −0.023435 
                 −0.029989 
                 −0.037946 
                 −0.030011 
               
               
                 Zc3h18 
                 −0.014044 
                 −0.004449 
                 0.018301 
                 0.014335 
                 0.028638 
                 0.029885 
               
               
                 Zeb2os 
                 0.011561 
                 −0.004064 
                 −0.007569 
                 −0.040244 
                 −0.029679 
                 −0.027164 
               
               
                 Zfhx3 
                 0.016317 
                 −0.003908 
                 −0.012561 
                 −0.031074 
                 −0.014626 
                 −0.011462 
               
               
                 Zfp212 
                 −0.004695 
                 −0.000668 
                 0.005345 
                 −0.005263 
                 0.004276 
                 0.009323 
               
               
                 Zfp330 
                 0.006770 
                 −0.006066 
                 −0.000733 
                 −0.018707 
                 −0.020203 
                 −0.030827 
               
               
                 Zfp35 
                 0.020093 
                 0.002335 
                 −0.022749 
                 −0.038052 
                 −0.015884 
                 −0.041656 
               
               
                 Zfp362 
                 0.002379 
                 −0.011557 
                 0.009102 
                 0.035827 
                 0.021264 
                 0.019315 
               
               
                 Zfp36l1 
                 0.010031 
                 −0.020700 
                 0.010448 
                 0.035114 
                 0.041138 
                 0.016446 
               
               
                 Zfp628 
                 0.018878 
                 −0.012513 
                 −0.006558 
                 0.005431 
                 −0.020178 
                 0.001984 
               
               
                 Zfp651 
                 −0.007410 
                 0.010234 
                 −0.002882 
                 0.023355 
                 0.014911 
                 0.014142 
               
               
                 Zfp710 
                 0.000379 
                 −0.013536 
                 0.013035 
                 0.017175 
                 0.033010 
                 0.025302 
               
               
                 Zfp809 
                 −0.013000 
                 0.011480 
                 0.001416 
                 0.003336 
                 −0.001140 
                 −0.008168 
               
               
                 Zfp839 
                 −0.002056 
                 0.000260 
                 0.001793 
                 0.006397 
                 0.014099 
                 0.007840 
               
               
                 Zfp85 
                 0.014042 
                 0.018837 
                 −0.033456 
                 −0.021231 
                 −0.046299 
                 −0.031123 
               
               
                 Zfp850 
                 0.010219 
                 −0.008903 
                 −0.001380 
                 0.006155 
                 −0.004383 
                 −0.006469 
               
               
                 Zfpm1 
                 −0.021619 
                 −0.001184 
                 0.022465 
                 0.000153 
                 0.020359 
                 −0.023700 
               
               
                 Zic5 
                 −0.011661 
                 0.014379 
                 −0.002840 
                 −0.037437 
                 −0.021909 
                 −0.049901 
               
               
                 Zmynd10 
                 −0.015754 
                 −0.000094 
                 0.015677 
                 −0.025473 
                 −0.032960 
                 −0.029013 
               
               
                 Zscan12 
                 0.004344 
                 −0.016879 
                 0.012376 
                 −0.016942 
                 −0.015238 
                 −0.011926 
               
               
                 Zscan2 
                 −0.004701 
                 0.013244 
                 −0.008638 
                 0.014394 
                 0.032285 
                 0.032744 
               
               
                 Zswim8 
                 −0.017699 
                 0.000092 
                 0.017393 
                 0.015412 
                 0.021578 
                 0.035259 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 1B 
               
               
                   
               
               
                 gene 
                 SP1 
                 SP2 
                 SP3 
                 SPF v ABX p-value 
                 Sp v ABX p-value 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1700017B05Rik 
                 0.018638 
                 −0.004432 
                 0.049365 
                 0.020742 
                 0.346030 
               
               
                 1810055G02Rik 
                 0.031917 
                 0.020735 
                 −0.014757 
                 0.003495 
                 0.971940 
               
               
                 2610015P09Rik 
                 0.018861 
                 −0.000999 
                 0.032038 
                 0.296571 
                 0.025047 
               
               
                 2610020C07Rik 
                 0.035140 
                 0.036800 
                 −0.012333 
                 0.992996 
                 0.011782 
               
               
                 2700046A07Rik 
                 −0.001661 
                 −0.007484 
                 −0.002094 
                 0.013359 
                 0.116251 
               
               
                 2810408I11Rik 
                 0.004373 
                 0.009511 
                 0.020696 
                 0.295913 
                 0.044638 
               
               
                 2810468N07Rik 
                 0.014534 
                 0.026114 
                 0.051083 
                 0.383007 
                 0.015117 
               
               
                 3830406C13Rik 
                 0.020414 
                 0.064631 
                 0.034712 
                 0.927670 
                 0.005845 
               
               
                 4930447A16Rik 
                 −0.028895 
                 −0.028465 
                 −0.018808 
                 0.049218 
                 0.914526 
               
               
                 4930511A08Rik 
                 0.011405 
                 0.005374 
                 0.003392 
                 0.781974 
                 0.036947 
               
               
                 4933439C10Rik 
                 −0.007199 
                 −0.023143 
                 −0.006832 
                 0.021055 
                 0.166271 
               
               
                 5930403L14Rik 
                 0.037099 
                 0.001931 
                 −0.005865 
                 0.047893 
                 0.233449 
               
               
                 6330415G19Rik 
                 −0.011281 
                 −0.015162 
                 −0.007935 
                 0.027276 
                 0.187974 
               
               
                 6330549D23Rik 
                 −0.018105 
                 −0.024910 
                 −0.055949 
                 0.002299 
                 0.030601 
               
               
                 6430573F11Rik 
                 0.031887 
                 0.018290 
                 0.038128 
                 0.014222 
                 0.629827 
               
               
                 6530402F18Rik 
                 0.006070 
                 −0.017917 
                 −0.021293 
                 0.209688 
                 0.043199 
               
               
                 9130019P16Rik 
                 −0.002109 
                 −0.019938 
                 −0.001767 
                 0.136514 
                 0.041045 
               
               
                 9430065F17Rik 
                 0.011807 
                 0.018180 
                 0.003938 
                 0.008398 
                 0.095445 
               
               
                 A330069E16Rik 
                 −0.031137 
                 −0.015269 
                 −0.018878 
                 0.023845 
                 0.535954 
               
               
                 A930003O13Rik 
                 −0.003694 
                 −0.002218 
                 −0.000522 
                 0.063207 
                 0.040377 
               
               
                 Acad9 
                 −0.020673 
                 −0.013996 
                 −0.036059 
                 0.964761 
                 0.003238 
               
               
                 Acsbg1 
                 −0.009494 
                 −0.002390 
                 −0.024497 
                 0.195912 
                 0.032880 
               
               
                 Acsf2 
                 0.007830 
                 0.021217 
                 0.002728 
                 0.715813 
                 0.026933 
               
               
                 Adamts8 
                 −0.005202 
                 −0.008857 
                 −0.014714 
                 0.008054 
                 0.365332 
               
               
                 Agap3 
                 0.003172 
                 −0.004897 
                 −0.009828 
                 0.036757 
                 0.180482 
               
               
                 Airn 
                 −0.032133 
                 0.008081 
                 −0.013357 
                 0.212826 
                 0.044750 
               
               
                 Ak7 
                 0.030155 
                 0.012369 
                 0.058683 
                 0.113220 
                 0.045880 
               
               
                 Aldoc 
                 0.019091 
                 0.005108 
                 −0.009872 
                 0.167400 
                 0.036699 
               
               
                 Alpl 
                 −0.018661 
                 −0.005526 
                 −0.019086 
                 0.819387 
                 0.014538 
               
               
                 Ankrd11 
                 0.007595 
                 0.014692 
                 0.002831 
                 0.897735 
                 0.004728 
               
               
                 Ankrd6 
                 0.018971 
                 0.010460 
                 0.002472 
                 0.187595 
                 0.028505 
               
               
                 Ap1s1 
                 0.011447 
                 0.022753 
                 0.017971 
                 0.041310 
                 0.298544 
               
               
                 Ap3s1 
                 −0.015266 
                 0.013899 
                 0.004645 
                 0.039435 
                 0.292725 
               
               
                 Arhgap10 
                 0.018213 
                 0.023605 
                 −0.012254 
                 0.329280 
                 0.020090 
               
               
                 Arid1a 
                 0.014766 
                 0.016211 
                 −0.004863 
                 0.039376 
                 0.036938 
               
               
                 Arl6ip1 
                 −0.014357 
                 −0.012329 
                 −0.038201 
                 0.466523 
                 0.016309 
               
               
                 Armt1 
                 0.007545 
                 0.015379 
                 0.022269 
                 0.032507 
                 0.176439 
               
               
                 Arrb2 
                 0.007874 
                 0.024731 
                 0.023994 
                 0.020977 
                 0.008638 
               
               
                 Arsa 
                 −0.028240 
                 −0.004958 
                 −0.037616 
                 0.334779 
                 0.034061 
               
               
                 Arxes2 
                 0.022150 
                 0.034058 
                 0.015139 
                 0.028753 
                 0.562367 
               
               
                 Ate1 
                 −0.016000 
                 −0.011618 
                 −0.026385 
                 0.590575 
                 0.028250 
               
               
                 Atg4d 
                 −0.022400 
                 −0.003575 
                 −0.023475 
                 0.581787 
                 0.042946 
               
               
                 Atn1 
                 −0.039266 
                 −0.019820 
                 −0.026779 
                 0.028445 
                 0.762889 
               
               
                 Atp5h 
                 0.006702 
                 −0.002794 
                 0.005798 
                 0.414676 
                 0.041331 
               
               
                 Atp6ap2 
                 0.001933 
                 −0.018617 
                 0.000114 
                 0.001091 
                 0.018647 
               
               
                 Atp6v1b2 
                 −0.008792 
                 −0.012530 
                 −0.025810 
                 0.069472 
                 0.029589 
               
               
                 Atp8b1 
                 0.003365 
                 0.013959 
                 0.000712 
                 0.034991 
                 0.104766 
               
               
                 Atpaf1 
                 0.010982 
                 0.016225 
                 0.009383 
                 0.026162 
                 0.675041 
               
               
                 Atxn2 
                 0.021957 
                 0.020479 
                 0.019710 
                 0.036812 
                 0.110005 
               
               
                 Aven 
                 0.004074 
                 0.016877 
                 0.016698 
                 0.028744 
                 0.212447 
               
               
                 AW209491 
                 0.003241 
                 0.022375 
                 0.015654 
                 0.010607 
                 0.424536 
               
               
                 AW549877 
                 −0.000175 
                 0.002798 
                 0.031642 
                 0.036804 
                 0.255979 
               
               
                 Axin2 
                 0.010689 
                 −0.004838 
                 0.018189 
                 0.015686 
                 0.104696 
               
               
                 B230307C23Rik 
                 −0.012088 
                 −0.017021 
                 −0.034730 
                 0.559672 
                 0.037047 
               
               
                 B3galt2 
                 −0.037332 
                 −0.008679 
                 −0.009353 
                 0.048749 
                 0.560575 
               
               
                 B4galt4 
                 0.007768 
                 0.027834 
                 −0.007646 
                 0.129087 
                 0.029637 
               
               
                 Bahcc1 
                 0.025570 
                 0.013260 
                 0.018734 
                 0.025823 
                 0.744577 
               
               
                 Baiap2l1 
                 0.026465 
                 0.023471 
                 0.030968 
                 0.048076 
                 0.251265 
               
               
                 BC020402 
                 −0.014143 
                 −0.034449 
                 −0.031436 
                 0.004676 
                 0.127490 
               
               
                 BC024139 
                 0.037316 
                 −0.009068 
                 0.019397 
                 0.223102 
                 0.008794 
               
               
                 Blzf1 
                 0.021608 
                 0.035501 
                 0.048987 
                 0.043345 
                 0.020862 
               
               
                 Bola1 
                 −0.000238 
                 −0.023571 
                 −0.011696 
                 0.165591 
                 0.030429 
               
               
                 Brd4 
                 0.017478 
                 −0.001701 
                 −0.003086 
                 0.044653 
                 0.090765 
               
               
                 Brox 
                 −0.012965 
                 −0.006479 
                 −0.024291 
                 0.027580 
                 0.408589 
               
               
                 C1galt1c1 
                 −0.037322 
                 −0.035471 
                 −0.025821 
                 0.111284 
                 0.007125 
               
               
                 C1ql3 
                 0.037193 
                 0.027143 
                 0.014681 
                 0.872241 
                 0.031389 
               
               
                 C330006A16Rik 
                 0.002048 
                 −0.021937 
                 −0.000064 
                 0.107636 
                 0.037658 
               
               
                 C77080 
                 −0.012379 
                 −0.018685 
                 −0.022032 
                 0.330408 
                 0.023274 
               
               
                 C77370 
                 −0.008607 
                 −0.018310 
                 −0.050701 
                 0.031353 
                 0.879897 
               
               
                 Cadm2 
                 −0.031666 
                 0.007890 
                 −0.057798 
                 0.028136 
                 0.492641 
               
               
                 Camk1d 
                 0.002103 
                 −0.021799 
                 −0.059723 
                 0.042962 
                 0.630926 
               
               
                 Camk2d 
                 −0.008343 
                 −0.012511 
                 −0.036507 
                 0.039911 
                 0.438039 
               
               
                 Capn3 
                 0.051819 
                 0.028995 
                 0.059326 
                 0.997838 
                 0.020373 
               
               
                 Capns2 
                 −0.003440 
                 −0.012476 
                 −0.000049 
                 0.088467 
                 0.033376 
               
               
                 Card9 
                 −0.023401 
                 −0.012078 
                 −0.017604 
                 0.546193 
                 0.034352 
               
               
                 Carns1 
                 0.024050 
                 0.039077 
                 0.042899 
                 0.081707 
                 0.011544 
               
               
                 Cartpt 
                 −0.035145 
                 −0.028518 
                 −0.033365 
                 0.073177 
                 0.029756 
               
               
                 Casp9 
                 −0.017788 
                 −0.036192 
                 −0.004406 
                 0.539597 
                 0.046217 
               
               
                 Casz1 
                 0.002292 
                 0.032986 
                 0.017368 
                 0.020482 
                 0.212097 
               
               
                 Cc2d1a 
                 0.097035 
                 0.099738 
                 −0.034594 
                 0.011647 
                 0.502015 
               
               
                 Ccbl2 
                 −0.006229 
                 0.000580 
                 0.001696 
                 0.043134 
                 0.054697 
               
               
                 Ccdc102a 
                 0.010610 
                 0.025094 
                 0.025529 
                 0.042402 
                 0.398813 
               
               
                 Ccdc137 
                 −0.039338 
                 −0.025673 
                 0.003822 
                 0.041148 
                 0.509689 
               
               
                 Ccdc162 
                 −0.013561 
                 −0.001696 
                 −0.010546 
                 0.144079 
                 0.027583 
               
               
                 Ccdc18 
                 −0.006137 
                 0.022216 
                 0.056094 
                 0.510450 
                 0.026744 
               
               
                 Ccdc71l 
                 −0.009176 
                 −0.006485 
                 0.005317 
                 0.093585 
                 0.049559 
               
               
                 Ccdc88b 
                 −0.016783 
                 −0.013084 
                 −0.010888 
                 0.364219 
                 0.042417 
               
               
                 Ccne1 
                 0.006161 
                 0.025424 
                 0.051622 
                 0.024593 
                 0.743732 
               
               
                 Cd34 
                 −0.026160 
                 −0.009905 
                 0.005988 
                 0.041522 
                 0.203911 
               
               
                 Cdc14b 
                 −0.001812 
                 −0.022454 
                 −0.006940 
                 0.142560 
                 0.028082 
               
               
                 Cdca2 
                 0.104941 
                 0.080389 
                 −0.102077 
                 0.028613 
                 0.652675 
               
               
                 Cdh20 
                 0.021184 
                 0.006032 
                 0.069896 
                 0.006466 
                 0.491841 
               
               
                 Cdh24 
                 0.042088 
                 0.015338 
                 0.007160 
                 0.030229 
                 0.528470 
               
               
                 Cdk6 
                 0.210440 
                 0.004094 
                 0.026616 
                 0.023904 
                 0.917203 
               
               
                 Cdr1 
                 0.035166 
                 0.051098 
                 0.010499 
                 0.020388 
                 0.027370 
               
               
                 Celsr2 
                 −0.014931 
                 0.014921 
                 −0.028445 
                 0.009650 
                 0.344513 
               
               
                 Cenpb 
                 0.015016 
                 0.020412 
                 0.012149 
                 0.021735 
                 0.450704 
               
               
                 Cep250 
                 0.018036 
                 0.018775 
                 0.014792 
                 0.048492 
                 0.764264 
               
               
                 Cep85l 
                 −0.007781 
                 0.011068 
                 −0.013573 
                 0.005658 
                 0.466966 
               
               
                 Cerk 
                 −0.010458 
                 −0.022563 
                 −0.016745 
                 0.411210 
                 0.019926 
               
               
                 Chml 
                 −0.004348 
                 0.005401 
                 0.025792 
                 0.423096 
                 0.004320 
               
               
                 Cit 
                 0.035513 
                 0.019627 
                 0.016589 
                 0.043276 
                 0.571517 
               
               
                 Cklf 
                 0.017535 
                 0.024583 
                 0.025101 
                 0.651082 
                 0.045471 
               
               
                 Cks1b 
                 −0.029856 
                 −0.029412 
                 −0.022161 
                 0.931788 
                 0.010456 
               
               
                 Clic3 
                 0.022312 
                 0.032462 
                 0.057672 
                 0.028433 
                 0.575114 
               
               
                 Clic6 
                 0.008745 
                 −0.058586 
                 −0.067127 
                 0.040161 
                 0.867916 
               
               
                 Clmn 
                 −0.034623 
                 −0.003282 
                 0.017750 
                 0.072765 
                 0.036426 
               
               
                 Clock 
                 −0.007399 
                 0.001717 
                 0.022307 
                 0.142595 
                 0.048130 
               
               
                 Cmc1 
                 −0.002725 
                 0.000092 
                 0.007827 
                 0.037876 
                 0.867438 
               
               
                 Cntnap5b 
                 0.028115 
                 0.034920 
                 0.036105 
                 0.049453 
                 0.478204 
               
               
                 Coch 
                 0.022825 
                 0.028824 
                 0.025967 
                 0.023138 
                 0.653057 
               
               
                 Col7a1 
                 −0.030405 
                 −0.004274 
                 −0.008851 
                 0.603427 
                 0.012553 
               
               
                 Commd9 
                 0.017122 
                 0.012919 
                 0.011169 
                 0.193251 
                 0.017034 
               
               
                 Cplx2 
                 −0.008452 
                 0.003553 
                 −0.020655 
                 0.181157 
                 0.035215 
               
               
                 Cpped1 
                 −0.022119 
                 −0.007738 
                 −0.015496 
                 0.041069 
                 0.287429 
               
               
                 Cramp1l 
                 0.011951 
                 0.015843 
                 −0.008129 
                 0.036474 
                 0.128318 
               
               
                 Creb3l1 
                 0.026893 
                 0.012759 
                 0.059775 
                 0.002724 
                 0.056047 
               
               
                 Creb5 
                 −0.011651 
                 −0.018401 
                 −0.014097 
                 0.214237 
                 0.021926 
               
               
                 Crebrf 
                 −0.014195 
                 −0.015965 
                 −0.014085 
                 0.026364 
                 0.460324 
               
               
                 Cryab 
                 0.002648 
                 0.045479 
                 −0.004698 
                 0.045840 
                 0.373904 
               
               
                 Cryzl1 
                 0.022225 
                 0.025653 
                 0.001220 
                 0.012692 
                 0.815966 
               
               
                 Ctrl 
                 0.022104 
                 0.018738 
                 0.001256 
                 0.360539 
                 0.047253 
               
               
                 Ctsa 
                 0.002983 
                 0.003214 
                 0.014448 
                 0.046033 
                 0.128335 
               
               
                 Ctss 
                 −0.017689 
                 −0.003842 
                 0.008522 
                 0.093315 
                 0.045646 
               
               
                 Cuedc1 
                 −0.000589 
                 0.026350 
                 −0.007672 
                 0.041105 
                 0.117277 
               
               
                 Cyb561 
                 −0.006971 
                 −0.019293 
                 −0.021704 
                 0.048446 
                 0.375684 
               
               
                 Cyb5a 
                 −0.000247 
                 0.012845 
                 0.022998 
                 0.036503 
                 0.249784 
               
               
                 Cycs 
                 0.025624 
                 0.038795 
                 0.042975 
                 0.207770 
                 0.005689 
               
               
                 Cyp27b1 
                 −0.012760 
                 0.008048 
                 −0.020800 
                 0.099154 
                 0.022989 
               
               
                 D030068K23Rik 
                 0.023832 
                 0.056173 
                 0.026594 
                 0.031285 
                 0.793041 
               
               
                 D11Wsu47e 
                 −0.025550 
                 −0.012995 
                 −0.005751 
                 0.198305 
                 0.015147 
               
               
                 Dbx2 
                 −0.014612 
                 −0.011878 
                 −0.008449 
                 0.271487 
                 0.049120 
               
               
                 Ddx25 
                 0.011662 
                 0.018683 
                 0.006078 
                 0.016479 
                 0.516485 
               
               
                 Ddx27 
                 0.015589 
                 0.003057 
                 0.016676 
                 0.478136 
                 0.003401 
               
               
                 Deb1 
                 −0.014179 
                 −0.023216 
                 −0.043748 
                 0.049450 
                 0.947544 
               
               
                 Dennd1c 
                 0.039914 
                 0.021151 
                 0.018293 
                 0.526756 
                 0.012549 
               
               
                 Dennd2a 
                 0.015498 
                 0.018643 
                 0.017465 
                 0.035084 
                 0.580602 
               
               
                 Dimt1 
                 0.023691 
                 −0.003179 
                 0.011145 
                 0.194220 
                 0.033471 
               
               
                 Dio3os 
                 −0.024838 
                 −0.034409 
                 −0.003964 
                 0.021019 
                 0.463275 
               
               
                 Dlx5 
                 0.008132 
                 0.013721 
                 0.015256 
                 0.169939 
                 0.010225 
               
               
                 Dmd 
                 −0.013903 
                 −0.025774 
                 −0.006702 
                 0.048507 
                 0.714606 
               
               
                 Dnaaf2 
                 0.036197 
                 0.008713 
                 0.025264 
                 0.031924 
                 0.673984 
               
               
                 Dnah8 
                 −0.016055 
                 0.001490 
                 −0.037444 
                 0.024992 
                 0.264581 
               
               
                 Dnase1 
                 0.023842 
                 0.009648 
                 0.013157 
                 0.197763 
                 0.010572 
               
               
                 Dok2 
                 0.003324 
                 0.008689 
                 0.025085 
                 0.034923 
                 0.239246 
               
               
                 Dpp10 
                 −0.015441 
                 −0.007954 
                 −0.079981 
                 0.046930 
                 0.923224 
               
               
                 Dpy19l3 
                 −0.008278 
                 −0.002545 
                 −0.039768 
                 0.035831 
                 0.361002 
               
               
                 E130012A19Rik 
                 0.031515 
                 0.049468 
                 0.017424 
                 0.038801 
                 0.968489 
               
               
                 E130307A14Rik 
                 −0.038934 
                 0.001919 
                 −0.024048 
                 0.583594 
                 0.043410 
               
               
                 E2f8 
                 0.026167 
                 0.034633 
                 0.008660 
                 0.009712 
                 0.917045 
               
               
                 Ece1 
                 0.015416 
                 0.011281 
                 0.018303 
                 0.017200 
                 0.212793 
               
               
                 Efhb 
                 −0.017393 
                 −0.024828 
                 −0.031038 
                 0.003463 
                 0.316554 
               
               
                 Elk4 
                 0.001924 
                 0.005306 
                 0.002035 
                 0.102711 
                 0.004677 
               
               
                 Emp2 
                 0.013323 
                 0.008407 
                 0.019759 
                 0.015086 
                 0.313877 
               
               
                 En2 
                 0.010765 
                 0.007161 
                 0.022204 
                 0.028315 
                 0.970905 
               
               
                 Epas1 
                 0.008288 
                 0.028333 
                 0.013615 
                 0.046416 
                 0.376189 
               
               
                 Ephb2 
                 0.007012 
                 0.015649 
                 0.016260 
                 0.035094 
                 0.363879 
               
               
                 Epor 
                 0.027620 
                 −0.013964 
                 −0.026050 
                 0.012732 
                 0.049408 
               
               
                 Erbb2 
                 −0.019501 
                 −0.005355 
                 −0.006818 
                 0.105376 
                 0.016819 
               
               
                 Esd 
                 0.016940 
                 −0.012689 
                 0.012556 
                 0.073803 
                 0.020485 
               
               
                 Exo5 
                 0.003297 
                 0.017595 
                 0.019780 
                 0.275763 
                 0.036255 
               
               
                 Exph5 
                 0.001529 
                 0.014966 
                 0.011504 
                 0.022686 
                 0.107954 
               
               
                 F11r 
                 0.004515 
                 0.013337 
                 −0.003539 
                 0.025888 
                 0.057087 
               
               
                 F8 
                 −0.053619 
                 −0.014388 
                 −0.017645 
                 0.033635 
                 0.718812 
               
               
                 Fah 
                 −0.001477 
                 −0.013936 
                 −0.017790 
                 0.034176 
                 0.192238 
               
               
                 Fam122b 
                 0.014118 
                 0.034620 
                 0.022356 
                 0.680812 
                 0.038356 
               
               
                 Fam126a 
                 0.015455 
                 0.001616 
                 0.017247 
                 0.468843 
                 0.048096 
               
               
                 Fam160b2 
                 −0.020819 
                 −0.023256 
                 −0.026721 
                 0.359031 
                 0.007140 
               
               
                 Fam199x 
                 −0.005638 
                 0.010653 
                 0.025052 
                 0.173394 
                 0.048549 
               
               
                 Fam19a1 
                 0.021594 
                 0.023319 
                 0.054835 
                 0.004305 
                 0.504384 
               
               
                 Fam207a 
                 0.033239 
                 0.023405 
                 −0.002020 
                 0.393933 
                 0.023381 
               
               
                 Fam208a 
                 0.014999 
                 0.021287 
                 −0.019797 
                 0.060989 
                 0.011493 
               
               
                 Fam20a 
                 −0.017786 
                 −0.002093 
                 −0.008460 
                 0.195143 
                 0.036055 
               
               
                 Fam43b 
                 0.036932 
                 0.021262 
                 −0.013308 
                 0.012179 
                 0.563795 
               
               
                 Fam76b 
                 0.038818 
                 0.043033 
                 0.034589 
                 0.729838 
                 0.010527 
               
               
                 Fgf1 
                 −0.018777 
                 −0.018809 
                 −0.024725 
                 0.046123 
                 0.735814 
               
               
                 Fkbp1b 
                 0.018456 
                 0.123274 
                 0.042743 
                 0.163818 
                 0.012659 
               
               
                 Fndc3c1 
                 −0.025908 
                 −0.035647 
                 −0.017845 
                 0.039584 
                 0.900612 
               
               
                 Fndc5 
                 −0.011716 
                 0.002985 
                 −0.030904 
                 0.239289 
                 0.043973 
               
               
                 Foxn2 
                 0.015202 
                 0.030201 
                 0.026947 
                 0.481911 
                 0.038159 
               
               
                 Frem3 
                 −0.004221 
                 −0.009371 
                 −0.010530 
                 0.136985 
                 0.034447 
               
               
                 Fuk 
                 0.017014 
                 0.031916 
                 0.014904 
                 0.046977 
                 0.738661 
               
               
                 Fut9 
                 −0.006006 
                 −0.008610 
                 −0.002278 
                 0.035590 
                 0.131621 
               
               
                 Gabra2 
                 −0.010751 
                 0.015139 
                 −0.020382 
                 0.024792 
                 0.032847 
               
               
                 Gabra4 
                 −0.008958 
                 −0.007002 
                 −0.049786 
                 0.023421 
                 0.316284 
               
               
                 Gabrg1 
                 0.034790 
                 0.025006 
                 0.006969 
                 0.056384 
                 0.026992 
               
               
                 Gabrg2 
                 0.016472 
                 0.031945 
                 0.004880 
                 0.009039 
                 0.020003 
               
               
                 Gale 
                 −0.031557 
                 −0.026603 
                 −0.014513 
                 0.717324 
                 0.031829 
               
               
                 Galntl6 
                 0.041419 
                 0.018695 
                 0.036613 
                 0.049727 
                 0.932152 
               
               
                 Gas2l1 
                 0.022574 
                 0.048417 
                 0.037917 
                 0.011182 
                 0.096764 
               
               
                 Gcc1 
                 0.015686 
                 0.013415 
                 0.044273 
                 0.014638 
                 0.069673 
               
               
                 Gcnt1 
                 −0.031554 
                 −0.005250 
                 0.017868 
                 0.005124 
                 0.030855 
               
               
                 Gemin4 
                 0.012289 
                 0.005809 
                 0.029216 
                 0.036616 
                 0.088258 
               
               
                 Glg1 
                 −0.010511 
                 −0.017862 
                 −0.025994 
                 0.021195 
                 0.284436 
               
               
                 Gli1 
                 0.047563 
                 0.006019 
                 0.009137 
                 0.027881 
                 0.024868 
               
               
                 Glis3 
                 −0.005923 
                 −0.028775 
                 −0.013641 
                 0.333521 
                 0.004438 
               
               
                 Glra2 
                 −0.016204 
                 −0.020663 
                 −0.015720 
                 0.351010 
                 0.043765 
               
               
                 Gm11346 
                 −0.019898 
                 −0.002056 
                 −0.027717 
                 0.022763 
                 0.920717 
               
               
                 Gm11974 
                 −0.014786 
                 −0.027986 
                 −0.018898 
                 0.353110 
                 0.031054 
               
               
                 Gm14164 
                 0.019515 
                 0.032459 
                 0.060170 
                 0.045991 
                 0.482338 
               
               
                 Gm15880 
                 −0.029035 
                 −0.014696 
                 −0.005096 
                 0.463778 
                 0.026944 
               
               
                 Gm16740 
                 0.012690 
                 0.014370 
                 0.067154 
                 0.022138 
                 0.447401 
               
               
                 Gm17750 
                 −0.006194 
                 0.027237 
                 0.018766 
                 0.027149 
                 0.330994 
               
               
                 Gm17769 
                 0.004824 
                 −0.004512 
                 −0.001662 
                 0.354129 
                 0.047460 
               
               
                 Gm20324 
                 −0.005273 
                 0.017530 
                 0.007365 
                 0.023321 
                 0.964918 
               
               
                 Gm6981 
                 −0.000080 
                 −0.015038 
                 −0.014025 
                 0.029086 
                 0.677523 
               
               
                 Gm7173 
                 0.008156 
                 −0.014436 
                 −0.014937 
                 0.019471 
                 0.976726 
               
               
                 Gpatch1 
                 0.431739 
                 −0.003996 
                 0.280313 
                 0.219813 
                 0.041289 
               
               
                 Gpm6a 
                 −0.002108 
                 −0.004307 
                 −0.014204 
                 0.027061 
                 0.087990 
               
               
                 Gpr137 
                 0.017024 
                 0.017506 
                 0.002054 
                 0.048779 
                 0.008619 
               
               
                 Gps2 
                 0.028868 
                 0.029826 
                 0.017192 
                 0.033398 
                 0.175325 
               
               
                 Grhl3 
                 0.009362 
                 −0.004203 
                 0.020328 
                 0.016927 
                 0.122013 
               
               
                 Gria1 
                 −0.013471 
                 −0.008409 
                 −0.069541 
                 0.948533 
                 0.016241 
               
               
                 Grik4 
                 0.026827 
                 0.054345 
                 0.052835 
                 0.922786 
                 0.011260 
               
               
                 Grin1 
                 0.010083 
                 0.012392 
                 0.080391 
                 0.038090 
                 0.915147 
               
               
                 Gsr 
                 −0.010725 
                 −0.003364 
                 −0.014168 
                 0.005286 
                 0.015590 
               
               
                 Gsta4 
                 0.012697 
                 0.017652 
                 0.043070 
                 0.023978 
                 0.803534 
               
               
                 Gstm6 
                 0.002286 
                 0.011797 
                 0.033479 
                 0.580243 
                 0.031027 
               
               
                 Gtf3c3 
                 0.090914 
                 0.003015 
                 0.013426 
                 0.011348 
                 0.286818 
               
               
                 Gucy1b3 
                 −0.004266 
                 0.009719 
                 −0.006044 
                 0.036949 
                 0.406598 
               
               
                 Hcn4 
                 0.019155 
                 0.016333 
                 −0.010748 
                 0.007430 
                 0.013347 
               
               
                 Hdgf 
                 0.008440 
                 0.017392 
                 0.027469 
                 0.048896 
                 0.058432 
               
               
                 Hebp2 
                 0.008291 
                 0.016743 
                 −0.009318 
                 0.049848 
                 0.160435 
               
               
                 Heca 
                 0.001433 
                 −0.001576 
                 −0.006025 
                 0.031399 
                 0.759350 
               
               
                 Hist1h2bg 
                 −0.019083 
                 −0.027260 
                 −0.008214 
                 0.110010 
                 0.046006 
               
               
                 Hist1h4b 
                 0.015243 
                 0.001834 
                 0.041077 
                 0.066468 
                 0.041696 
               
               
                 Hist2h3b 
                 −0.004677 
                 −0.003625 
                 0.032882 
                 0.020184 
                 0.907305 
               
               
                 Hmgb1 
                 0.052492 
                 −0.014904 
                 0.043829 
                 0.035175 
                 0.488319 
               
               
                 Hnrnph2 
                 −0.004077 
                 0.003290 
                 0.038536 
                 0.034967 
                 0.116214 
               
               
                 Hpca 
                 −0.020165 
                 −0.015338 
                 −0.073335 
                 0.770022 
                 0.032902 
               
               
                 Hs6st2 
                 −0.028857 
                 −0.013711 
                 −0.032853 
                 0.371762 
                 0.043064 
               
               
                 Hsd3b6 
                 0.002284 
                 −0.036960 
                 −0.041971 
                 0.049202 
                 0.961327 
               
               
                 Htr2c 
                 0.003401 
                 0.010898 
                 0.046356 
                 0.032362 
                 0.919583 
               
               
                 ICa1 
                 −0.001715 
                 −0.012359 
                 −0.047567 
                 0.020965 
                 0.637254 
               
               
                 Il1rap 
                 0.025303 
                 0.038021 
                 0.015543 
                 0.004016 
                 0.909725 
               
               
                 Inpp5f 
                 −0.015269 
                 −0.007679 
                 −0.025605 
                 0.031420 
                 0.393950 
               
               
                 Iqcb1 
                 0.016659 
                 0.007740 
                 0.012789 
                 0.007165 
                 0.008668 
               
               
                 Irs1 
                 0.011937 
                 0.005462 
                 0.005573 
                 0.037654 
                 0.717298 
               
               
                 Irs4 
                 0.011919 
                 0.020235 
                 −0.026328 
                 0.217456 
                 0.035111 
               
               
                 Irx2 
                 0.025774 
                 0.000577 
                 0.017257 
                 0.039486 
                 0.253553 
               
               
                 Ism1 
                 −0.006999 
                 0.005236 
                 0.002375 
                 0.027306 
                 0.005707 
               
               
                 Itga1 
                 −0.010312 
                 0.021954 
                 0.021167 
                 0.046973 
                 0.404084 
               
               
                 Jak2 
                 −0.011425 
                 −0.010001 
                 −0.012302 
                 0.049424 
                 0.049844 
               
               
                 Kank2 
                 0.028024 
                 0.031366 
                 0.025058 
                 0.164542 
                 0.031171 
               
               
                 Kcnd1 
                 0.000315 
                 −0.014348 
                 −0.013143 
                 0.046624 
                 0.385936 
               
               
                 Kcnh2 
                 0.018974 
                 0.015479 
                 0.028023 
                 0.036855 
                 0.634312 
               
               
                 Kctd5 
                 0.028005 
                 0.009671 
                 0.001124 
                 0.134992 
                 0.026917 
               
               
                 Kdm1b 
                 −0.008466 
                 −0.004597 
                 0.003408 
                 0.014526 
                 0.123053 
               
               
                 Khk 
                 0.027590 
                 0.009110 
                 0.005840 
                 0.816021 
                 0.022254 
               
               
                 Kif27 
                 −0.023430 
                 −0.000880 
                 −0.004603 
                 0.024864 
                 0.054733 
               
               
                 Kiss1r 
                 −0.003762 
                 −0.024762 
                 −0.000403 
                 0.024309 
                 0.304737 
               
               
                 Kitl 
                 −0.005738 
                 −0.011038 
                 −0.023262 
                 0.157655 
                 0.032926 
               
               
                 Kmt2d 
                 0.096876 
                 0.065628 
                 0.005145 
                 0.162448 
                 0.034969 
               
               
                 Knstrn 
                 −0.020536 
                 0.005269 
                 0.041495 
                 0.037241 
                 0.295019 
               
               
                 Kri1 
                 −0.006259 
                 −0.007213 
                 −0.004070 
                 0.008644 
                 0.181103 
               
               
                 Lama5 
                 0.011523 
                 0.008852 
                 −0.001478 
                 0.123793 
                 0.025420 
               
               
                 Lamtor5 
                 0.001776 
                 0.005946 
                 0.012516 
                 0.015375 
                 0.027874 
               
               
                 Lars2 
                 −0.007470 
                 −0.015614 
                 −0.005249 
                 0.027652 
                 0.282781 
               
               
                 Lbh 
                 −0.011895 
                 −0.007872 
                 −0.009642 
                 0.023526 
                 0.073483 
               
               
                 Lingo1 
                 −0.000110 
                 −0.012315 
                 −0.051318 
                 0.108854 
                 0.040087 
               
               
                 Lipt2 
                 −0.006800 
                 −0.009957 
                 0.015414 
                 0.014612 
                 0.013521 
               
               
                 Lmx1b 
                 −0.000908 
                 −0.010401 
                 0.002150 
                 0.188943 
                 0.020214 
               
               
                 LOC100862268 
                 −0.016624 
                 −0.012309 
                 −0.017358 
                 0.325547 
                 0.018428 
               
               
                 Loxl2 
                 −0.019644 
                 0.063617 
                 0.043249 
                 0.043888 
                 0.047965 
               
               
                 Lpcat1 
                 −0.010591 
                 −0.030695 
                 −0.012863 
                 0.046482 
                 0.084511 
               
               
                 Lppr4 
                 0.011425 
                 0.009866 
                 0.011001 
                 0.046268 
                 0.472235 
               
               
                 Lrfn1 
                 −0.010303 
                 −0.016641 
                 −0.025801 
                 0.668287 
                 0.043557 
               
               
                 Lrp1b 
                 −0.009740 
                 −0.013339 
                 −0.058090 
                 0.004669 
                 0.342096 
               
               
                 Lrp5 
                 0.010065 
                 −0.012394 
                 −0.016613 
                 0.027559 
                 0.016373 
               
               
                 Lrr1 
                 −0.006631 
                 −0.005001 
                 −0.007123 
                 0.012557 
                 0.157604 
               
               
                 Lrrc29 
                 −0.011883 
                 −0.032442 
                 −0.014291 
                 0.006046 
                 0.586725 
               
               
                 Lsm12 
                 −0.016523 
                 −0.014899 
                 −0.023510 
                 0.045080 
                 0.000860 
               
               
                 Magel2 
                 −0.004009 
                 −0.017388 
                 −0.010299 
                 0.381163 
                 0.027234 
               
               
                 Map1a 
                 0.033386 
                 0.033376 
                 −0.012497 
                 0.746662 
                 0.008371 
               
               
                 Map3k14 
                 −0.023962 
                 −0.029427 
                 −0.042339 
                 0.017543 
                 0.746454 
               
               
                 Map3k19 
                 −0.000946 
                 0.018588 
                 −0.009143 
                 0.039981 
                 0.515667 
               
               
                 Map3k5 
                 −0.080160 
                 −0.077027 
                 −0.080044 
                 0.024002 
                 0.039304 
               
               
                 Map7d1 
                 0.018792 
                 0.008053 
                 0.007415 
                 0.783532 
                 0.011803 
               
               
                 Mapk8 
                 −0.004944 
                 −0.011569 
                 −0.014343 
                 0.049502 
                 0.018504 
               
               
                 Mapkapk2 
                 0.012316 
                 0.007317 
                 0.019279 
                 0.042055 
                 0.348361 
               
               
                 Maz 
                 0.014000 
                 0.006374 
                 0.015134 
                 0.017093 
                 0.213478 
               
               
                 Mcc 
                 0.023116 
                 0.027314 
                 0.010548 
                 0.020662 
                 0.218258 
               
               
                 Mcfd2 
                 0.009132 
                 0.018027 
                 0.003504 
                 0.020501 
                 0.251379 
               
               
                 Mdc1 
                 0.038584 
                 −0.004562 
                 0.011400 
                 0.032824 
                 0.393925 
               
               
                 Med10 
                 0.008634 
                 −0.009239 
                 0.015578 
                 0.238786 
                 0.049517 
               
               
                 Mier2 
                 0.005842 
                 0.008916 
                 0.014886 
                 0.003054 
                 0.188440 
               
               
                 Mier3 
                 −0.016152 
                 0.019792 
                 0.016457 
                 0.063984 
                 0.022814 
               
               
                 Mir3081 
                 −0.015702 
                 0.000201 
                 −0.014117 
                 0.014512 
                 0.060784 
               
               
                 Mir411 
                 −0.020688 
                 −0.001140 
                 −0.009810 
                 0.099324 
                 0.031397 
               
               
                 Mir6236 
                 0.012516 
                 −0.003319 
                 0.013316 
                 0.181492 
                 0.034979 
               
               
                 Mir6353 
                 0.006485 
                 0.004458 
                 0.005059 
                 0.024869 
                 0.945670 
               
               
                 Mllt6 
                 0.035633 
                 0.030711 
                 0.029398 
                 0.015416 
                 0.013526 
               
               
                 Mpeg1 
                 −0.008183 
                 0.002809 
                 −0.022620 
                 0.041339 
                 0.100833 
               
               
                 Mpnd 
                 −0.041822 
                 −0.042997 
                 −0.045820 
                 0.012077 
                 0.148882 
               
               
                 Mrpl22 
                 0.020230 
                 −0.003243 
                 0.022213 
                 0.183606 
                 0.048035 
               
               
                 Mrps18b 
                 0.016544 
                 0.007835 
                 0.026162 
                 0.016675 
                 0.064731 
               
               
                 Mrps33 
                 0.018575 
                 0.010301 
                 0.020973 
                 0.302529 
                 0.044620 
               
               
                 Mtcl1 
                 0.024644 
                 0.005838 
                 0.009012 
                 0.662584 
                 0.026472 
               
               
                 Mttp 
                 −0.012786 
                 −0.016086 
                 −0.000475 
                 0.339442 
                 0.028464 
               
               
                 Mtx3 
                 0.000892 
                 0.015037 
                 0.011776 
                 0.047104 
                 0.445012 
               
               
                 Mum1 
                 −0.037530 
                 −0.033799 
                 −0.040715 
                 0.048264 
                 0.199749 
               
               
                 Mvk 
                 −0.024913 
                 −0.025223 
                 −0.010270 
                 0.252348 
                 0.047026 
               
               
                 Myh14 
                 0.006294 
                 0.004921 
                 0.021386 
                 0.020653 
                 0.598630 
               
               
                 Myo5b 
                 −0.021851 
                 −0.007909 
                 −0.015674 
                 0.713086 
                 0.044993 
               
               
                 Myo6 
                 −0.030094 
                 −0.019024 
                 −0.032756 
                 0.042033 
                 0.167508 
               
               
                 Mzf1 
                 −0.029430 
                 −0.030792 
                 −0.038825 
                 0.314615 
                 0.043194 
               
               
                 Nans 
                 0.006464 
                 0.005343 
                 0.015659 
                 0.871903 
                 0.041878 
               
               
                 Nap1l5 
                 −0.019423 
                 −0.014022 
                 −0.020209 
                 0.985883 
                 0.013392 
               
               
                 Ncmap 
                 −0.005604 
                 −0.010358 
                 −0.007121 
                 0.176687 
                 0.035744 
               
               
                 Ncor2 
                 −0.029185 
                 −0.031420 
                 −0.051929 
                 0.031998 
                 0.782385 
               
               
                 Ndufs4 
                 −0.021712 
                 −0.017029 
                 −0.015262 
                 0.168259 
                 0.046741 
               
               
                 Necab1 
                 −0.003495 
                 −0.010480 
                 −0.001512 
                 0.015047 
                 0.041328 
               
               
                 Nek11 
                 0.035591 
                 0.003662 
                 −0.003164 
                 0.040074 
                 0.698646 
               
               
                 Nexn 
                 −0.001135 
                 0.015271 
                 0.041953 
                 0.012171 
                 0.556460 
               
               
                 Nfs1 
                 −0.010039 
                 −0.014407 
                 −0.021444 
                 0.286667 
                 0.047529 
               
               
                 Nipa2 
                 −0.022149 
                 −0.006146 
                 0.003086 
                 0.368505 
                 0.039745 
               
               
                 Nipal2 
                 −0.014866 
                 −0.011007 
                 −0.020556 
                 0.022815 
                 0.280505 
               
               
                 Nmd3 
                 −0.002417 
                 −0.014549 
                 −0.011316 
                 0.042559 
                 0.157364 
               
               
                 Nol4 
                 −0.011938 
                 −0.007492 
                 −0.016707 
                 0.022873 
                 0.291237 
               
               
                 Notch3 
                 0.024110 
                 0.012356 
                 0.058559 
                 0.028682 
                 0.153752 
               
               
                 Nptxr 
                 0.009444 
                 −0.001270 
                 −0.037407 
                 0.049716 
                 0.380070 
               
               
                 Npy1r 
                 −0.005141 
                 −0.031118 
                 −0.040788 
                 0.025919 
                 0.738308 
               
               
                 Nr5a2 
                 0.018370 
                 −0.004263 
                 0.063872 
                 0.129014 
                 0.036957 
               
               
                 Nrcam 
                 −0.027789 
                 −0.036241 
                 0.005793 
                 0.568245 
                 0.040336 
               
               
                 Nsun6 
                 −0.024628 
                 −0.024481 
                 −0.007071 
                 0.845330 
                 0.044071 
               
               
                 Ntn1 
                 −0.000454 
                 0.004978 
                 −0.022781 
                 0.039911 
                 0.523536 
               
               
                 Ntng1 
                 −0.020643 
                 −0.009866 
                 −0.072752 
                 0.018614 
                 0.014514 
               
               
                 Nudt11 
                 −0.034167 
                 −0.042052 
                 −0.043198 
                 0.005847 
                 0.110883 
               
               
                 Nup214 
                 −0.016064 
                 −0.010920 
                 −0.017894 
                 0.227635 
                 0.015183 
               
               
                 Oxsm 
                 0.000108 
                 −0.027689 
                 −0.024744 
                 0.043659 
                 0.656196 
               
               
                 Pcdh20 
                 −0.046386 
                 0.011414 
                 −0.051713 
                 0.030321 
                 0.296739 
               
               
                 Pcdh7 
                 −0.009136 
                 −0.003067 
                 −0.021611 
                 0.029445 
                 0.358402 
               
               
                 Pcdha11 
                 −0.016520 
                 −0.006303 
                 −0.033986 
                 0.717416 
                 0.015041 
               
               
                 Pcdha7-g 
                 0.015709 
                 0.021023 
                 0.019379 
                 0.000916 
                 0.055733 
               
               
                 Pcdhb12 
                 −0.022938 
                 −0.027371 
                 −0.035569 
                 0.084061 
                 0.046426 
               
               
                 Pcdhb20 
                 0.015139 
                 0.023659 
                 −0.028714 
                 0.022486 
                 0.393469 
               
               
                 Pcdhb22 
                 −0.026040 
                 0.003917 
                 −0.043745 
                 0.006210 
                 0.731849 
               
               
                 Pcdhgb5 
                 −0.006142 
                 −0.031473 
                 −0.043141 
                 0.029102 
                 0.811529 
               
               
                 Pde4d 
                 −0.016159 
                 −0.022694 
                 −0.035925 
                 0.043676 
                 0.872993 
               
               
                 Pdia4 
                 0.014149 
                 0.006092 
                 0.041729 
                 0.042968 
                 0.065241 
               
               
                 Pdss2 
                 −0.005670 
                 0.010365 
                 0.003197 
                 0.048344 
                 0.738162 
               
               
                 Pex11b 
                 −0.011763 
                 −0.031600 
                 −0.021690 
                 0.389610 
                 0.012478 
               
               
                 Pgbd1 
                 0.005909 
                 0.027700 
                 0.045936 
                 0.190243 
                 0.037125 
               
               
                 Phf5a 
                 0.013185 
                 −0.012260 
                 0.030815 
                 0.015158 
                 0.015097 
               
               
                 Phyhip 
                 −0.027370 
                 −0.056446 
                 −0.017696 
                 0.096354 
                 0.042792 
               
               
                 Pip4k2a 
                 −0.005582 
                 0.001053 
                 0.018494 
                 0.155510 
                 0.018271 
               
               
                 Pisd-ps3 
                 0.015974 
                 0.014262 
                 0.041224 
                 0.008284 
                 0.084244 
               
               
                 Plagl2 
                 −0.024060 
                 −0.038497 
                 −0.053664 
                 0.289714 
                 0.044201 
               
               
                 Plcd 
                 −0.026596 
                 0.007100 
                 −0.023762 
                 0.372860 
                 0.013936 
               
               
                 Pld2 
                 −0.001880 
                 −0.010518 
                 0.005762 
                 0.302955 
                 0.044939 
               
               
                 Plek 
                 0.014273 
                 0.035281 
                 0.001704 
                 0.042558 
                 0.134711 
               
               
                 Plekhn1 
                 0.001478 
                 0.015303 
                 0.008011 
                 0.003210 
                 0.261697 
               
               
                 Plp2 
                 −0.042152 
                 −0.007583 
                 −0.062007 
                 0.026038 
                 0.658918 
               
               
                 Plxna3 
                 −0.012183 
                 −0.025374 
                 −0.010284 
                 0.043487 
                 0.564727 
               
               
                 Pmaip1 
                 −0.033413 
                 −0.021818 
                 −0.033117 
                 0.002717 
                 0.521253 
               
               
                 Poli 
                 −0.027254 
                 −0.016261 
                 −0.021448 
                 0.430680 
                 0.033796 
               
               
                 Polr3c 
                 0.032982 
                 0.024394 
                 0.034560 
                 0.118620 
                 0.016826 
               
               
                 Polr3gl 
                 −0.026299 
                 −0.019661 
                 −0.007798 
                 0.015321 
                 0.342353 
               
               
                 Polrmt 
                 −0.008579 
                 −0.003345 
                 −0.019847 
                 0.088073 
                 0.013188 
               
               
                 Pou2f2 
                 0.023079 
                 0.011029 
                 0.023008 
                 0.073404 
                 0.016659 
               
               
                 Pou6f2 
                 −0.019664 
                 −0.023395 
                 −0.044026 
                 0.778235 
                 0.038026 
               
               
                 Ppap2b 
                 −0.013443 
                 −0.018915 
                 −0.041617 
                 0.000165 
                 0.023058 
               
               
                 Ppp1r3fos 
                 −0.022930 
                 −0.034195 
                 −0.022321 
                 0.177841 
                 0.036070 
               
               
                 Prr12 
                 0.000408 
                 0.006244 
                 −0.014256 
                 0.038289 
                 0.218137 
               
               
                 Prr36 
                 −0.001649 
                 −0.016707 
                 −0.011756 
                 0.425295 
                 0.020097 
               
               
                 Prrc2a 
                 0.028833 
                 0.018199 
                 −0.008305 
                 0.010493 
                 0.492499 
               
               
                 Prrg1 
                 −0.029342 
                 −0.025494 
                 −0.039247 
                 0.033721 
                 0.673008 
               
               
                 Psg16 
                 −0.034634 
                 −0.027356 
                 −0.043255 
                 0.026303 
                 0.465575 
               
               
                 Pstpip2 
                 −0.023110 
                 −0.016239 
                 −0.022393 
                 0.117648 
                 0.014116 
               
               
                 Ptch2 
                 0.019629 
                 0.021218 
                 0.017524 
                 0.043590 
                 0.500718 
               
               
                 Ptk2b 
                 −0.033335 
                 −0.046415 
                 −0.020438 
                 0.024813 
                 0.295167 
               
               
                 Ptprf 
                 0.027177 
                 0.012659 
                 0.005862 
                 0.056717 
                 0.017803 
               
               
                 Pus7 
                 −0.012930 
                 −0.010325 
                 −0.022733 
                 0.040313 
                 0.162859 
               
               
                 Pxn 
                 0.008070 
                 0.027649 
                 0.044857 
                 0.034487 
                 0.376161 
               
               
                 Rapgef1 
                 0.026076 
                 0.008201 
                 −0.010935 
                 0.016439 
                 0.161608 
               
               
                 Rcan2 
                 −0.006063 
                 −0.002870 
                 −0.042517 
                 0.008899 
                 0.489697 
               
               
                 Reps2 
                 −0.002231 
                 0.005908 
                 −0.055310 
                 0.038873 
                 0.146985 
               
               
                 Rgs17 
                 −0.018515 
                 −0.027431 
                 −0.040410 
                 0.034399 
                 0.393311 
               
               
                 Rhof 
                 0.014475 
                 −0.008579 
                 −0.036521 
                 0.544761 
                 0.031812 
               
               
                 Ric8b 
                 −0.022708 
                 −0.009367 
                 −0.008797 
                 0.047973 
                 0.057975 
               
               
                 Rilpl1 
                 0.018131 
                 0.014790 
                 0.026362 
                 0.029016 
                 0.268459 
               
               
                 Rin3 
                 0.018495 
                 0.001943 
                 −0.017445 
                 0.000006 
                 0.000009 
               
               
                 Rint1 
                 0.000529 
                 −0.020646 
                 −0.026900 
                 0.178331 
                 0.038604 
               
               
                 Rn45s 
                 −0.024654 
                 −0.026216 
                 −0.056303 
                 0.023593 
                 0.309697 
               
               
                 Rnf126 
                 −0.013695 
                 −0.010554 
                 −0.002962 
                 0.040727 
                 0.066057 
               
               
                 Rnpep 
                 0.018020 
                 0.009638 
                 0.014513 
                 0.347253 
                 0.022571 
               
               
                 Rnpepl1 
                 0.014489 
                 0.006981 
                 −0.012017 
                 0.792351 
                 0.024831 
               
               
                 Rpl19 
                 0.051816 
                 0.002780 
                 −0.007315 
                 0.133847 
                 0.036330 
               
               
                 Rpl23a 
                 0.020451 
                 0.039462 
                 0.034281 
                 0.029363 
                 0.197851 
               
               
                 Rpl3 
                 0.007858 
                 −0.009074 
                 0.018929 
                 0.422576 
                 0.046796 
               
               
                 Rpn2 
                 0.004384 
                 0.007587 
                 0.016861 
                 0.954155 
                 0.011491 
               
               
                 Rps12 
                 0.004672 
                 0.011981 
                 0.018951 
                 0.021748 
                 0.521966 
               
               
                 Rps2 
                 −0.002592 
                 0.061200 
                 0.044995 
                 0.078156 
                 0.017869 
               
               
                 Rwdd2b 
                 −0.025276 
                 −0.036682 
                 −0.018135 
                 0.049240 
                 0.612527 
               
               
                 Rxfp3 
                 0.003426 
                 −0.016492 
                 −0.010865 
                 0.609581 
                 0.042259 
               
               
                 Ryr2 
                 0.006002 
                 −0.014505 
                 −0.067860 
                 0.036844 
                 0.235109 
               
               
                 S100a11 
                 0.011627 
                 0.020455 
                 0.031766 
                 0.463287 
                 0.029505 
               
               
                 Sall2 
                 0.001304 
                 0.005391 
                 0.019090 
                 0.126702 
                 0.016347 
               
               
                 Sarnp 
                 0.024587 
                 0.022710 
                 0.020918 
                 0.015203 
                 0.317385 
               
               
                 Sash3 
                 −0.038351 
                 −0.033062 
                 −0.032397 
                 0.048925 
                 0.223167 
               
               
                 Scaf1 
                 0.010574 
                 0.029857 
                 0.014365 
                 0.017131 
                 0.535487 
               
               
                 Scd4 
                 0.010427 
                 0.007816 
                 0.010159 
                 0.022813 
                 0.340116 
               
               
                 Scn1a 
                 −0.024593 
                 −0.017361 
                 −0.047242 
                 0.012351 
                 0.015618 
               
               
                 Scrib 
                 0.019390 
                 0.013519 
                 0.010277 
                 0.006038 
                 0.169800 
               
               
                 Scrt1 
                 0.009206 
                 −0.010709 
                 0.048185 
                 0.018440 
                 0.057750 
               
               
                 Scube1 
                 −0.031373 
                 −0.015979 
                 −0.039461 
                 0.402390 
                 0.049442 
               
               
                 Scx 
                 −0.021443 
                 −0.024279 
                 −0.055883 
                 0.001297 
                 0.018102 
               
               
                 Sdha 
                 0.003565 
                 0.013838 
                 0.012220 
                 0.030519 
                 0.813458 
               
               
                 Sema3f 
                 −0.010080 
                 −0.025308 
                 −0.044520 
                 0.047955 
                 0.410188 
               
               
                 Sema6a 
                 −0.036419 
                 −0.053792 
                 −0.062240 
                 0.014880 
                 0.000975 
               
               
                 Senp7 
                 −0.023767 
                 −0.022385 
                 −0.017452 
                 0.025477 
                 0.982830 
               
               
                 Sfxn4 
                 −0.026274 
                 −0.015870 
                 −0.004334 
                 0.030785 
                 0.122576 
               
               
                 Sgk3 
                 −0.010629 
                 −0.028230 
                 −0.043582 
                 0.038094 
                 0.818412 
               
               
                 Sh3bgrl2 
                 −0.030125 
                 −0.014748 
                 −0.065309 
                 0.043309 
                 0.381214 
               
               
                 Sh3bp4 
                 −0.002200 
                 0.015595 
                 0.010299 
                 0.028955 
                 0.614611 
               
               
                 Shisa9 
                 0.004435 
                 −0.013156 
                 −0.006440 
                 0.032249 
                 0.231346 
               
               
                 Shmt2 
                 0.016896 
                 0.008504 
                 0.033869 
                 0.018573 
                 0.009103 
               
               
                 Sigmar1 
                 0.018354 
                 0.032954 
                 0.014076 
                 0.008505 
                 0.283162 
               
               
                 Slc10a3 
                 −0.006094 
                 0.037101 
                 0.007231 
                 0.012541 
                 0.622515 
               
               
                 Slc15a4 
                 −0.028915 
                 −0.003453 
                 0.003059 
                 0.033385 
                 0.012740 
               
               
                 Slc17a5 
                 −0.005964 
                 −0.009700 
                 −0.021747 
                 0.160643 
                 0.002824 
               
               
                 Slc1a5 
                 0.006838 
                 −0.018641 
                 0.025391 
                 0.067103 
                 0.023492 
               
               
                 Slc22a12 
                 −0.035056 
                 −0.017173 
                 −0.044232 
                 0.033994 
                 0.998381 
               
               
                 Slc24a3 
                 −0.029199 
                 −0.031243 
                 −0.034836 
                 0.034300 
                 0.121706 
               
               
                 Slc25a1 
                 0.002239 
                 0.000769 
                 −0.018320 
                 0.618569 
                 0.041550 
               
               
                 Slc29a4 
                 0.035100 
                 0.035407 
                 0.012864 
                 0.064916 
                 0.031130 
               
               
                 Slc35f3 
                 −0.021162 
                 −0.038196 
                 −0.038610 
                 0.210300 
                 0.038326 
               
               
                 Slc36a4 
                 −0.032364 
                 −0.036189 
                 −0.038922 
                 0.045337 
                 0.647478 
               
               
                 Slc37a2 
                 0.013064 
                 −0.013841 
                 −0.012535 
                 0.024325 
                 0.261275 
               
               
                 Slc52a2 
                 0.006082 
                 −0.021065 
                 −0.021000 
                 0.026544 
                 0.305108 
               
               
                 Slc6a8 
                 0.013178 
                 0.029358 
                 0.009919 
                 0.034750 
                 0.641018 
               
               
                 Slco2b1 
                 0.033816 
                 0.028829 
                 −0.011804 
                 0.046977 
                 0.556896 
               
               
                 Slitrk4 
                 −0.026302 
                 −0.011678 
                 −0.009704 
                 0.030259 
                 0.242694 
               
               
                 Smarca5-ps 
                 −0.046446 
                 −0.010108 
                 −0.014790 
                 0.521651 
                 0.034725 
               
               
                 Smim20 
                 −0.008697 
                 −0.033753 
                 −0.019639 
                 0.001939 
                 0.043682 
               
               
                 Smim3 
                 0.007351 
                 0.013678 
                 0.019040 
                 0.321499 
                 0.027693 
               
               
                 Smim8 
                 −0.004283 
                 0.032803 
                 0.039115 
                 0.410445 
                 0.032207 
               
               
                 Smpdl3a 
                 −0.023696 
                 −0.021220 
                 −0.050329 
                 0.148628 
                 0.023830 
               
               
                 Snhg1 
                 0.001395 
                 0.007754 
                 0.041992 
                 0.040737 
                 0.401207 
               
               
                 Snora15 
                 −0.022127 
                 −0.023847 
                 −0.015141 
                 0.226943 
                 0.011575 
               
               
                 Snora23 
                 0.000930 
                 0.005307 
                 0.029130 
                 0.027766 
                 0.697849 
               
               
                 Snord91a 
                 0.014503 
                 0.027195 
                 0.003526 
                 0.473271 
                 0.042213 
               
               
                 Socs6 
                 −0.007457 
                 −0.009155 
                 0.033285 
                 0.736071 
                 0.031995 
               
               
                 Sox13 
                 0.022255 
                 0.009403 
                 0.037126 
                 0.105570 
                 0.003372 
               
               
                 Sox4 
                 −0.011833 
                 −0.007360 
                 −0.006515 
                 0.039293 
                 0.175793 
               
               
                 Spry3 
                 −0.044153 
                 −0.012015 
                 −0.023512 
                 0.465213 
                 0.044173 
               
               
                 Spsb1 
                 −0.034845 
                 −0.021166 
                 −0.039115 
                 0.045003 
                 0.271950 
               
               
                 Sqrdl 
                 −0.016003 
                 −0.003938 
                 −0.005364 
                 0.043374 
                 0.256555 
               
               
                 Srbd1 
                 −0.001835 
                 0.018203 
                 0.030946 
                 0.952371 
                 0.012168 
               
               
                 Src 
                 0.025614 
                 0.011662 
                 −0.005819 
                 0.071406 
                 0.034419 
               
               
                 Srcap 
                 0.013889 
                 0.010037 
                 0.001168 
                 0.033057 
                 0.137941 
               
               
                 Srp54b 
                 0.003898 
                 0.033965 
                 0.021679 
                 0.924223 
                 0.030002 
               
               
                 St3gal3 
                 0.014004 
                 0.000853 
                 −0.030394 
                 0.009096 
                 0.281437 
               
               
                 St8sia6 
                 −0.029909 
                 −0.014567 
                 −0.036468 
                 0.046459 
                 0.906104 
               
               
                 Stard5 
                 −0.012664 
                 −0.021311 
                 −0.039125 
                 0.024665 
                 0.079743 
               
               
                 Stxbp3-ps 
                 −0.041555 
                 −0.034946 
                 −0.010246 
                 0.001381 
                 0.502383 
               
               
                 Supt6 
                 0.005264 
                 0.005502 
                 0.001141 
                 0.681687 
                 0.027374 
               
               
                 Sv2b 
                 −0.027744 
                 0.019267 
                 −0.038717 
                 0.047655 
                 0.525657 
               
               
                 Svopl 
                 0.007425 
                 0.033150 
                 0.037057 
                 0.045666 
                 0.443553 
               
               
                 Synpo2 
                 0.018899 
                 0.009129 
                 0.038190 
                 0.047874 
                 0.241506 
               
               
                 Syt17 
                 −0.016357 
                 −0.011964 
                 −0.018973 
                 0.042350 
                 0.423596 
               
               
                 Syt3 
                 −0.003711 
                 0.003187 
                 −0.036472 
                 0.007208 
                 0.195332 
               
               
                 Syvn1 
                 0.038976 
                 0.013094 
                 0.000391 
                 0.047307 
                 0.115132 
               
               
                 Tacc1 
                 −0.031168 
                 −0.026673 
                 −0.028568 
                 0.826929 
                 0.012318 
               
               
                 Tada1 
                 0.007209 
                 −0.009175 
                 −0.013250 
                 0.003895 
                 0.037537 
               
               
                 Taf1a 
                 0.001648 
                 0.006096 
                 0.011809 
                 0.022153 
                 0.233880 
               
               
                 Taf4a 
                 −0.025033 
                 −0.020285 
                 −0.046823 
                 0.005478 
                 0.017439 
               
               
                 Taok2 
                 0.013017 
                 0.006513 
                 0.006553 
                 0.015141 
                 0.109765 
               
               
                 Tas1r1 
                 −0.030587 
                 −0.031952 
                 −0.033793 
                 0.517938 
                 0.026129 
               
               
                 Tatdn1 
                 −0.027544 
                 −0.017623 
                 −0.027386 
                 0.215561 
                 0.009350 
               
               
                 Tbc1d10a 
                 −0.032363 
                 −0.010165 
                 −0.021231 
                 0.421191 
                 0.032140 
               
               
                 Tbc1d4 
                 0.025394 
                 0.060200 
                 0.001359 
                 0.021283 
                 0.067948 
               
               
                 Tbc1d9 
                 −0.000923 
                 −0.010408 
                 −0.030709 
                 0.027054 
                 0.039845 
               
               
                 Tbx2 
                 −0.009147 
                 0.027857 
                 −0.009265 
                 0.041785 
                 0.641620 
               
               
                 Tcf3 
                 0.015857 
                 0.017926 
                 0.036660 
                 0.024555 
                 0.700512 
               
               
                 Tenm1 
                 −0.012318 
                 −0.013079 
                 −0.051320 
                 0.008946 
                 0.644578 
               
               
                 Tfcp2l1 
                 −0.023127 
                 −0.010180 
                 −0.078130 
                 0.160185 
                 0.021888 
               
               
                 Them4 
                 0.016759 
                 0.003096 
                 0.018030 
                 0.131877 
                 0.004031 
               
               
                 Thoc7 
                 −0.009868 
                 −0.045513 
                 −0.047251 
                 0.011767 
                 0.084348 
               
               
                 Thsd4 
                 −0.027370 
                 −0.025840 
                 −0.055998 
                 0.028647 
                 0.316746 
               
               
                 Tigar 
                 0.022699 
                 −0.001033 
                 0.025361 
                 0.883286 
                 0.044757 
               
               
                 Timm9 
                 −0.011365 
                 −0.019122 
                 −0.053909 
                 0.005228 
                 0.626517 
               
               
                 Tm4sf1 
                 0.008194 
                 0.021260 
                 0.043833 
                 0.387656 
                 0.030942 
               
               
                 Tmc7 
                 0.039193 
                 0.002364 
                 0.011948 
                 0.007576 
                 0.141423 
               
               
                 Tmem170b 
                 0.029747 
                 0.047088 
                 0.010735 
                 0.024699 
                 0.531595 
               
               
                 Tmem180 
                 −0.003963 
                 −0.038750 
                 −0.026556 
                 0.034971 
                 0.013434 
               
               
                 Tmem185b 
                 −0.017185 
                 −0.036561 
                 −0.043515 
                 0.117839 
                 0.047499 
               
               
                 Tmem203 
                 −0.009165 
                 0.019021 
                 0.007152 
                 0.017875 
                 0.111372 
               
               
                 Tmem29 
                 −0.024870 
                 0.006120 
                 −0.014121 
                 0.005064 
                 0.035425 
               
               
                 Tmem81 
                 −0.011352 
                 −0.013953 
                 0.000315 
                 0.176745 
                 0.048772 
               
               
                 Tmem8b 
                 0.012024 
                 −0.012465 
                 −0.026381 
                 0.037704 
                 0.842948 
               
               
                 Tmem9 
                 −0.031405 
                 −0.009650 
                 −0.030312 
                 0.077764 
                 0.027167 
               
               
                 Tmppe 
                 −0.004292 
                 0.003297 
                 −0.016387 
                 0.033296 
                 0.741548 
               
               
                 Tnfrsf19 
                 0.013263 
                 0.011495 
                 0.032847 
                 0.010138 
                 0.745693 
               
               
                 Tomm5 
                 −0.030245 
                 −0.028115 
                 −0.017621 
                 0.025877 
                 0.534480 
               
               
                 Tpcn1 
                 0.030030 
                 0.042158 
                 −0.001416 
                 0.055730 
                 0.035567 
               
               
                 Trim13 
                 0.010992 
                 −0.000632 
                 −0.001788 
                 0.019807 
                 0.860509 
               
               
                 Trim9 
                 0.016622 
                 0.044166 
                 0.015041 
                 0.022648 
                 0.393678 
               
               
                 Tshz3 
                 −0.006809 
                 −0.017449 
                 −0.038020 
                 0.251620 
                 0.020916 
               
               
                 Tspan13 
                 0.015132 
                 0.003456 
                 0.011988 
                 0.490731 
                 0.028235 
               
               
                 Ttc39aos1 
                 0.012827 
                 0.009621 
                 0.024336 
                 0.013988 
                 0.394096 
               
               
                 Tuft1 
                 −0.028904 
                 −0.018103 
                 −0.038787 
                 0.022311 
                 0.801384 
               
               
                 Txnrd3 
                 0.017104 
                 −0.003527 
                 −0.020654 
                 0.044973 
                 0.471432 
               
               
                 Ubap2 
                 0.010416 
                 0.014737 
                 0.022548 
                 0.131212 
                 0.024075 
               
               
                 Ubb 
                 0.027814 
                 −0.001839 
                 −0.001780 
                 0.003985 
                 0.001519 
               
               
                 Ube2j2 
                 −0.035874 
                 −0.031261 
                 −0.035263 
                 0.042438 
                 0.731477 
               
               
                 Ube2r2 
                 0.014788 
                 0.011837 
                 0.019800 
                 0.016326 
                 0.296872 
               
               
                 Uck2 
                 0.003620 
                 0.015707 
                 0.024337 
                 0.177775 
                 0.023297 
               
               
                 Utp11l 
                 0.006537 
                 0.021734 
                 0.008165 
                 0.159251 
                 0.046604 
               
               
                 Vac14 
                 0.005399 
                 −0.009972 
                 −0.019644 
                 0.338518 
                 0.010671 
               
               
                 Vamp7 
                 −0.020817 
                 −0.038301 
                 −0.028122 
                 0.032586 
                 0.196035 
               
               
                 Vangl2 
                 0.027570 
                 0.011155 
                 −0.004344 
                 0.014601 
                 0.180576 
               
               
                 Vasp 
                 0.022478 
                 0.009889 
                 0.013098 
                 0.060357 
                 0.027992 
               
               
                 Vcpip1 
                 −0.000370 
                 0.002315 
                 0.011009 
                 0.064182 
                 0.044061 
               
               
                 Vwa8 
                 0.016948 
                 −0.021590 
                 −0.004131 
                 0.010375 
                 0.793385 
               
               
                 Vwc2l 
                 −0.003988 
                 −0.004835 
                 −0.011561 
                 0.006493 
                 0.055444 
               
               
                 Wfs1 
                 −0.017658 
                 0.003797 
                 −0.027011 
                 0.036360 
                 0.126604 
               
               
                 Xlr3a 
                 −0.001045 
                 0.007115 
                 −0.029520 
                 0.041290 
                 0.002879 
               
               
                 Xylt1 
                 −0.001563 
                 −0.034582 
                 −0.036647 
                 0.343656 
                 0.043102 
               
               
                 Yipf2 
                 −0.008423 
                 −0.021047 
                 −0.016476 
                 0.011844 
                 0.321436 
               
               
                 Zbtb45 
                 −0.009410 
                 −0.032308 
                 −0.026251 
                 0.854544 
                 0.033262 
               
               
                 Zbtb46 
                 −0.020206 
                 −0.010232 
                 −0.043049 
                 0.014133 
                 0.275086 
               
               
                 Zc3h10 
                 0.022429 
                 0.016654 
                 0.023124 
                 0.011035 
                 0.054442 
               
               
                 Zc3h12b 
                 −0.017373 
                 −0.022318 
                 −0.048962 
                 0.041581 
                 0.514408 
               
               
                 Zc3h18 
                 0.010884 
                 0.005419 
                 0.032800 
                 0.136289 
                 0.006597 
               
               
                 Zeb2os 
                 −0.016041 
                 0.000340 
                 −0.017544 
                 0.001761 
                 0.130684 
               
               
                 Zfhx3 
                 0.007403 
                 0.013639 
                 0.012865 
                 0.551818 
                 0.046705 
               
               
                 Zfp212 
                 −0.030576 
                 −0.008674 
                 −0.030651 
                 0.815397 
                 0.038840 
               
               
                 Zfp330 
                 −0.038913 
                 −0.038766 
                 −0.026564 
                 0.011652 
                 0.035811 
               
               
                 Zfp35 
                 0.005323 
                 0.035270 
                 −0.028103 
                 0.807564 
                 0.016913 
               
               
                 Zfp362 
                 0.010752 
                 0.000498 
                 0.009570 
                 0.033042 
                 0.123477 
               
               
                 Zfp36l1 
                 −0.004408 
                 0.005355 
                 0.048543 
                 0.039471 
                 0.379769 
               
               
                 Zfp628 
                 0.075411 
                 0.012088 
                 0.002199 
                 0.011149 
                 0.177113 
               
               
                 Zfp651 
                 −0.000945 
                 −0.008611 
                 −0.019467 
                 0.147411 
                 0.023751 
               
               
                 Zfp710 
                 −0.000914 
                 0.022121 
                 0.031224 
                 0.038968 
                 0.540622 
               
               
                 Zfp809 
                 −0.027268 
                 −0.025658 
                 −0.034189 
                 0.952685 
                 0.028810 
               
               
                 Zfp839 
                 −0.023959 
                 −0.009542 
                 −0.016994 
                 0.466468 
                 0.040120 
               
               
                 Zfp85 
                 −0.022880 
                 −0.021387 
                 0.018662 
                 0.042518 
                 0.131547 
               
               
                 Zfp850 
                 0.023734 
                 0.022703 
                 0.027762 
                 0.886796 
                 0.028716 
               
               
                 Zfpm1 
                 −0.036579 
                 −0.024816 
                 −0.040454 
                 0.003382 
                 0.120900 
               
               
                 Zic5 
                 −0.009495 
                 −0.010065 
                 −0.046133 
                 0.832814 
                 0.025530 
               
               
                 Zmynd10 
                 −0.034549 
                 −0.026550 
                 −0.023509 
                 0.014819 
                 0.028386 
               
               
                 Zscan12 
                 −0.001104 
                 0.005937 
                 0.033403 
                 0.262373 
                 0.036247 
               
               
                 Zscan2 
                 0.017638 
                 0.030782 
                 0.035367 
                 0.040146 
                 0.929530 
               
               
                 Zswim8 
                 0.015606 
                 0.024358 
                 −0.011696 
                 0.041154 
                 0.222639 
               
               
                   
               
            
           
         
       
     
     Example 6: Table 2 for Examples 1-3, Provided as Parts Tables 2A and 2B 
     Tables 2A and 2B (collectively “Table 2”) relate 16S rDNA sequencing of SPF vs. Sp fecal microbiota. The “No” in the tables 2A and 2B is used to connect the two tables to each other (e.g., to relate the taxonomic unit of Table 2A to the values in Table 2B, which do not fit into a single table here due to space constraints), and need not correspond to the “No” used in Tables 3A and 3B. 
     
       
         
           
               
               
             
               
                 TABLE 2A 
               
               
                   
               
               
                 #OTU ID 
                 No 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 Unassigned; Other; Other; Other; Other; Other 
                 1 
               
               
                 k_Bacteria; p_Actinobacteria; c_Actinobacteria; o_Bifidobacteriales; 
                 2 
               
               
                 f_Bifidobacteriaceae; g_ Bifidobacterium   
               
               
                 k_Bacteria; p_Actinobacteria; c_Coriobacteriia; o_Coriobacteriales; 
                 3 
               
               
                 f_Coriobacteriaceae; g 
               
               
                 k_Bacteria; p_Actinobacteria; c_Coriobacteriia; o_Coriobacteriales; 
                 4 
               
               
                 f_Coriobacteriaceae; g_ Adlercreutzia   
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; f_; g 
                 5 
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; f_Bacteroidaceae; 
                 6 
               
               
                 g_ Bacteroides   
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; 
                 7 
               
               
                 f_Porphyromonadaceae; g_ Parabacteroides   
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; f_Prevotellaceae; 
                 8 
               
               
                 g_ Prevotella   
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; f_Rikenellaceae; 
                 9 
               
               
                 g —   
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; f_S24-7; g —   
                 10 
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; 
                 11 
               
               
                 f_[Odoribacteraceae]; g_ Odoribacter   
               
               
                 k_Bacteria; p_Cyanobacteria; c_4C0d-2; o_MLE1-12; f_; g —   
                 12 
               
               
                 k_Bacteria; p_Cyanobacteria; c_4C0d-2; o_YS2; f_; g —   
                 13 
               
               
                 k_Bacteria; p_Cyanobacteria; c_Chloroplast; o_Streptophyta; f_; g —   
                 14 
               
               
                 k_Bacteria; p_Firmicutes; c_Bacilli; Other; Other; Other 
                 15 
               
               
                 k_Bacteria; p_Firmicutes; c_Bacilli; o_Bacillales; Other; Other 
                 16 
               
               
                 k_Bacteria; p_Firmicutes; c_Bacilli; o_Bacillales; f_Bacillaceae; g_ Bacillus   
                 17 
               
               
                 k_Bacteria; p_Firmicutes; c_Bacilli; o_Bacillales; f_Staphylococcaceae; 
                 18 
               
               
                 g_ Staphylococcus   
               
               
                 k_Bacteria; p_Firmicutes; c_Bacilli; o_Lactobacillales; f_Enterococcaceae; 
                 19 
               
               
                 g_ Enterococcus   
               
               
                 k_Bacteria; p_Firmicutes; c_Bacilli; o_Lactobacillales; f_Lactobacillaceae; 
                 20 
               
               
                 g_ Lactobacillus   
               
               
                 k_Bacteria; p_Firmicutes; c_Bacilli; o_Lactobacillales; f_Streptococcaceae; 
                 21 
               
               
                 g_ Lactococcus   
               
               
                 k_Bacteria; p_Firmicutes; c_Bacilli; o_Lactobacillales; f_Streptococcaceae; 
                 22 
               
               
                 g_ Streptococcus   
               
               
                 k_Bacteria; p_Firmicutes; c_Bacilli; o_Turicibacterales; f_Turicibacteraceae; 
                 23 
               
               
                 g_ Turicibacter   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; Other; Other 
                 24 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_; g —   
                 25 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Clostridiaceae; 
                 26 
               
               
                 Other 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Clostridiaceae; g —   
                 27 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Clostridiaceae; 
                 28 
               
               
                 g_ Candidatus Arthromitus   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Clostridiaceae; 
                 29 
               
               
                 g_ Clostridium   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Dehalobacteriaceae; 
                 30 
               
               
                 g_ Dehalobacterium   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Lachnospiraceae; 
                 31 
               
               
                 Other 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Lachnospiraceae; g —   
                 32 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Lachnospiraceae; 
                 33 
               
               
                 g_ Blautia   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Lachnospiraceae; 
                 34 
               
               
                 g_ Coprococcus   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Lachnospiraceae; 
                 35 
               
               
                 g_ Dorea   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Lachnospiraceae; 
                 36 
               
               
                 g_ Roseburia   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Lachnospiraceae; 
                 37 
               
               
                 g_[ Ruminococcus ] 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; 
                 38 
               
               
                 f_Peptostreptococcaceae; g —   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Ruminococcaceae; 
                 39 
               
               
                 Other 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Ruminococcaceae; g —   
                 40 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Ruminococcaceae; 
                 41 
               
               
                 g_ Oscillospira   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Ruminococcaceae; 
                 42 
               
               
                 g_ Ruminococcus   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_[Mogibacteriaceae]; 
                 43 
               
               
                 g —   
               
               
                 k_Bacteria; p_Firmicutes; c_Erysipelotrichi; o_Erysipelotrichales; 
                 44 
               
               
                 f_Erysipelotrichaceae; g —   
               
               
                 k_Bacteria; p_Firmicutes; c_Erysipelotrichi; o_Erysipelotrichales; 
                 45 
               
               
                 f_Erysipelotrichaceae; g_ Allobaculum   
               
               
                 k_Bacteria; p_Proteobacteria; c_Alphaproteobacteria; o_; f_; g —   
                 46 
               
               
                 k_Bacteria; p_Proteobacteria; c_Betaproteobacteria; o_Burkholderiales; 
                 47 
               
               
                 f_Alcaligenaceae; g_ Sutterella   
               
               
                 k_Bacteria; p_Proteobacteria; c_Deltaproteobacteria; o_Desulfovibrionales; 
                 48 
               
               
                 f_Desulfovibrionaceae; g —   
               
               
                 k_Bacteria; p_Proteobacteria; c_Deltaproteobacteria; o_Desulfovibrionales; 
                 49 
               
               
                 f_Desulfovibrionaceae; g_ Bilophila   
               
               
                 k_Bacteria; p_Proteobacteria; c_Deltaproteobacteria; o_Desulfovibrionales; 
                 50 
               
               
                 f_Desulfovibrionaceae; g_ Desulfovibrio   
               
               
                 k_Bacteria; p_Proteobacteria; c_Gammaproteobacteria; o_Enterobacteriales; 
                 51 
               
               
                 f_Enterobacteriaceae; Other 
               
               
                 k_Bacteria; p_Proteobacteria; c_Gammaproteobacteria; o_Enterobacteriales; 
                 52 
               
               
                 f_Enterobacteriaceae; g —   
               
               
                 k_Bacteria; p_Proteobacteria; c_Gammaproteobacteria; o_Enterobacteriales; 
                 53 
               
               
                 f_Enterobacteriaceae; g_ Morganella   
               
               
                 k_Bacteria; p_Proteobacteria; c_Gammaproteobacteria; o_Enterobacteriales; 
                 54 
               
               
                 f_Enterobacteriaceae; g_ Proteus   
               
               
                 k_Bacteria; p_Proteobacteria; c_Gammaproteobacteria; o_Pseudomonadales; 
                 55 
               
               
                 f_Moraxellaceae; g —   
               
               
                 k_Bacteria; p_Proteobacteria; c_Gammaproteobacteria; o_Pseudomonadales; 
                 56 
               
               
                 f_Moraxellaceae; g_ Acinetobacter   
               
               
                 k_Bacteria; p_Tenericutes; c_Mollicutes; o_Anaeroplasmatales; 
                 57 
               
               
                 f_Anaeroplasmataceae; g_ Anaeroplasma   
               
               
                 k_Bacteria; p_Tenericutes; c_Mollicutes; o_RF39; f_; g —   
                 58 
               
               
                 k_Bacteria; p_Verrucomicrobia; c_Verrucomicrobiae; o_Verrucomicrobiales; 
                 59 
               
               
                 f_Verrucomicrobiaceae; g_ Akkermansia   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 2B 
               
               
                   
               
               
                 No 
                 SPF 
                 SPF 
                 SPF 
                 SPF 
                 Sp 
                 Sp 
                 Sp 
                 Sp 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 1 
                 0.000053 
                 0.000035 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 2 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 3 
                 0.000088 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 4 
                 0.001069 
                 0.001073 
                 0.000369 
                 0.000643 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 5 
                 0.002174 
                 0.000969 
                 0.002277 
                 0.001608 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 6 
                 0.087961 
                 0.035185 
                 0.062068 
                 0.049326 
                 0.000018 
                 0.000014 
                 0.000020 
                 0.000000 
               
               
                 7 
                 0.002016 
                 0.002388 
                 0.006137 
                 0.009789 
                 0.000129 
                 0.000086 
                 0.000059 
                 0.000000 
               
               
                 8 
                 0.027451 
                 0.008757 
                 0.024723 
                 0.017608 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 9 
                 0.006083 
                 0.065299 
                 0.047169 
                 0.077124 
                 0.000000 
                 0.000043 
                 0.000000 
                 0.000000 
               
               
                 10 
                 0.620863 
                 0.237054 
                 0.501377 
                 0.319813 
                 0.000331 
                 0.000229 
                 0.000357 
                 0.000195 
               
               
                 11 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 12 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 13 
                 0.001683 
                 0.001160 
                 0.003990 
                 0.000784 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 14 
                 0.000000 
                 0.000000 
                 0.000217 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 15 
                 0.000000 
                 0.000000 
                 0.000087 
                 0.000040 
                 0.000000 
                 0.000000 
                 0.000020 
                 0.000000 
               
               
                 16 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 17 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 18 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 19 
                 0.000035 
                 0.000017 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 20 
                 0.038231 
                 0.004586 
                 0.025243 
                 0.006854 
                 0.000202 
                 0.000243 
                 0.000258 
                 0.000180 
               
               
                 21 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000015 
               
               
                 22 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 23 
                 0.001350 
                 0.000485 
                 0.020776 
                 0.008281 
                 0.035306 
                 0.007929 
                 0.000119 
                 0.002869 
               
               
                 24 
                 0.000000 
                 0.000000 
                 0.000043 
                 0.000000 
                 0.000644 
                 0.000057 
                 0.000000 
                 0.000015 
               
               
                 25 
                 0.085945 
                 0.313621 
                 0.132398 
                 0.249824 
                 0.499917 
                 0.542613 
                 0.509793 
                 0.411759 
               
               
                 26 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000754 
                 0.000072 
                 0.000991 
                 0.000075 
               
               
                 27 
                 0.001017 
                 0.000588 
                 0.000542 
                 0.000462 
                 0.081099 
                 0.009517 
                 0.039468 
                 0.018443 
               
               
                 28 
                 0.024120 
                 0.001021 
                 0.001453 
                 0.000784 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 29 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000975 
                 0.000014 
                 0.000218 
                 0.000165 
               
               
                 30 
                 0.000561 
                 0.001315 
                 0.000976 
                 0.002633 
                 0.000846 
                 0.000572 
                 0.000000 
                 0.000000 
               
               
                 31 
                 0.000245 
                 0.001004 
                 0.000087 
                 0.000221 
                 0.001490 
                 0.000887 
                 0.013163 
                 0.000315 
               
               
                 32 
                 0.038143 
                 0.134285 
                 0.036802 
                 0.103013 
                 0.143194 
                 0.232651 
                 0.139694 
                 0.244785 
               
               
                 33 
                 0.000000 
                 0.000017 
                 0.000000 
                 0.000020 
                 0.000000 
                 0.000043 
                 0.000000 
                 0.000030 
               
               
                 34 
                 0.001613 
                 0.004431 
                 0.001496 
                 0.001869 
                 0.013339 
                 0.012923 
                 0.016057 
                 0.013517 
               
               
                 35 
                 0.000684 
                 0.001713 
                 0.002299 
                 0.005829 
                 0.005041 
                 0.001288 
                 0.003251 
                 0.001877 
               
               
                 36 
                 0.000000 
                 0.000017 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 37 
                 0.004645 
                 0.012098 
                 0.006636 
                 0.013447 
                 0.038526 
                 0.026434 
                 0.042124 
                 0.007284 
               
               
                 38 
                 0.000018 
                 0.000000 
                 0.000000 
                 0.000020 
                 0.000000 
                 0.000043 
                 0.000000 
                 0.000015 
               
               
                 39 
                 0.000070 
                 0.001142 
                 0.000087 
                 0.000382 
                 0.000110 
                 0.001331 
                 0.001388 
                 0.003935 
               
               
                 40 
                 0.008116 
                 0.040325 
                 0.019887 
                 0.029768 
                 0.059831 
                 0.073648 
                 0.083733 
                 0.179830 
               
               
                 41 
                 0.020281 
                 0.044219 
                 0.015614 
                 0.037024 
                 0.035545 
                 0.063358 
                 0.036990 
                 0.090396 
               
               
                 42 
                 0.001630 
                 0.018051 
                 0.008176 
                 0.016080 
                 0.029088 
                 0.017990 
                 0.007929 
                 0.006233 
               
               
                 43 
                 0.000000 
                 0.000294 
                 0.000000 
                 0.000181 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 44 
                 0.000824 
                 0.000675 
                 0.000586 
                 0.001990 
                 0.014774 
                 0.002218 
                 0.012449 
                 0.001517 
               
               
                 45 
                 0.000088 
                 0.000744 
                 0.003405 
                 0.001508 
                 0.000000 
                 0.000014 
                 0.000000 
                 0.000000 
               
               
                 46 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 47 
                 0.009886 
                 0.006352 
                 0.015506 
                 0.013467 
                 0.000000 
                 0.000000 
                 0.000059 
                 0.000000 
               
               
                 48 
                 0.000105 
                 0.000952 
                 0.000195 
                 0.001246 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 49 
                 0.000298 
                 0.005175 
                 0.000130 
                 0.001367 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 50 
                 0.001087 
                 0.004050 
                 0.001345 
                 0.011658 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 51 
                 0.000035 
                 0.000017 
                 0.000260 
                 0.000040 
                 0.000055 
                 0.000043 
                 0.000000 
                 0.000030 
               
               
                 52 
                 0.000876 
                 0.000121 
                 0.043374 
                 0.008884 
                 0.000129 
                 0.000186 
                 0.000198 
                 0.000240 
               
               
                 53 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 54 
                 0.000053 
                 0.000052 
                 0.000065 
                 0.000020 
                 0.000018 
                 0.000072 
                 0.000040 
                 0.000015 
               
               
                 55 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 56 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 57 
                 0.008169 
                 0.043008 
                 0.003231 
                 0.000985 
                 0.024212 
                 0.000000 
                 0.034552 
                 0.016235 
               
               
                 58 
                 0.002384 
                 0.007667 
                 0.009889 
                 0.005186 
                 0.014406 
                 0.005424 
                 0.057031 
                 0.000015 
               
               
                 59 
                 0.000053 
                 0.000035 
                 0.001084 
                 0.000221 
                 0.000018 
                 0.000057 
                 0.000040 
                 0.000015 
               
               
                   
               
            
           
         
       
     
     Example 7: Table 3 for Examples 1-3, Provided as Parts Tables 3A and 3B 
     Tables 3A and 3B (collectively “Table 3”) relate to fecal 16S rDNA sequencing from BD colonized dams. The “No” in the tables 3A and 3B is used to connect the two tables to each other (e.g., to relate the taxonomic unit of Table 3A to the values in Table 3B, which do not fit into a single table here due to space constraints), and need not correspond to the “No” used in Tables 2A and 2B. 
     
       
         
           
               
               
             
               
                 TABLE 3A 
               
               
                   
               
               
                 Taxonomy 
                 No 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 Unassigned; Other; Other; Other; Other; Other 
                 1 
               
               
                 k_Bacteria; p_Actinobacteria; c_Coriobacteriia; o_Coriobacteriales; 
                 2 
               
               
                 f_Coriobacteriaceae; g_ Adlercreutzia   
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; f_; g —   
                 3 
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; f_Bacteroidaceae; 
                 4 
               
               
                 g_ Bacteroides   
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; 
                 5 
               
               
                 f_Porphyromonadaceae; g_ Parabacteroides   
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; f_Prevotellaceae; 
                 6 
               
               
                 g_ Prevotella   
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; f_Rikenellaceae; 
                 7 
               
               
                 g —   
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; f_Rikenellaceae; 
                 8 
               
               
                 g_AF12 
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; f_S24-7; g —   
                 9 
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; 
                 10 
               
               
                 f_[Odoribacteraceae]; g_ Odoribacter   
               
               
                 k_Bacteria; p_Bacteroidetes; c_Bacteroidia; o_Bacteroidales; 
                 11 
               
               
                 f_[Paraprevotellaceae]; g_[ Prevotella ] 
               
               
                 k_Bacteria; p_Cyanobacteria; c_4C0d-2; o_YS2; f_; g —   
                 12 
               
               
                 k_Bacteria; p_Deferribacteres; c_Deferribacteres; o_Deferribacterales; 
                 13 
               
               
                 f_Deferribacteraceae; g_ Mucispirillum   
               
               
                 k_Bacteria; p_Firmicutes; c_Bacilli; o_Bacillales; Other; Other 
                 14 
               
               
                 k_Bacteria; p_Firmicutes; c_Bacilli; o_Lactobacillales; f_Enterococcaceae; 
                 15 
               
               
                 g_ Enterococcus   
               
               
                 k_Bacteria; p_Firmicutes; c_Bacilli; o_Lactobacillales; f_Lactobacillaceae; 
                 16 
               
               
                 g_ Lactobacillus   
               
               
                 k_Bacteria; p_Firmicutes; c_Bacilli; o_Turicibacterales; f_Turicibacteraceae; 
                 17 
               
               
                 g_ Turicibacter   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; Other; Other 
                 18 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_; g —   
                 19 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Christensenellaceae; 
                 20 
               
               
                 g —   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Clostridiaceae; 
                 21 
               
               
                 Other 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Clostridiaceae; g —   
                 22 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Clostridiaceae; 
                 23 
               
               
                 g_ Candidatus Arthromitus   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Clostridiaceae; 
                 24 
               
               
                 g_ Clostridium   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Dehalobacteriaceae; 
                 25 
               
               
                 g_ Dehalobacterium   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Lachnospiraceae; 
                 26 
               
               
                 Other 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Lachnospiraceae; g —   
                 27 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Lachnospiraceae; 
                 28 
               
               
                 g_ Blautia   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Lachnospiraceae; 
                 29 
               
               
                 g_ Coprococcus   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Lachnospiraceae; 
                 30 
               
               
                 g_ Dorea   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Lachnospiraceae; 
                 31 
               
               
                 g_[ Ruminococcus ] 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Peptococcaceae; g —   
                 32 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; 
                 33 
               
               
                 f_Peptostreptococcaceae; Other 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; 
                 34 
               
               
                 f_Peptostreptococcaceae; g —   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Ruminococcaceae; g —   
                 35 
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Ruminococcaceae; 
                 36 
               
               
                 g_ Oscillospira   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_Ruminococcaceae; 
                 37 
               
               
                 g_ Ruminococcus   
               
               
                 k_Bacteria; p_Firmicutes; c_Clostridia; o_Clostridiales; f_[Mogibacteriaceae]; 
                 38 
               
               
                 g —   
               
               
                 k_Bacteria; p_Firmicutes; c_Erysipelotrichi; o_Erysipelotrichales; 
                 39 
               
               
                 f_Erysipelotrichaceae; g —   
               
               
                 k_Bacteria; p_Firmicutes; c_Erysipelotrichi; o_Erysipelotrichales; 
                 40 
               
               
                 f_Erysipelotrichaceae; g_ Allobaculum   
               
               
                 k_Bacteria; p_Firmicutes; c_Erysipelotrichi; o_Erysipelotrichales; 
                 41 
               
               
                 f_Erysipelotrichaceae; g_ Coprobacillus   
               
               
                 k_Bacteria; p_Firmicutes; c_Erysipelotrichi; o_Erysipelotrichales; 
                 42 
               
               
                 f_Erysipelotrichaceae; g_[ Eubacterium ] 
               
               
                 k_Bacteria; p_Proteobacteria; c_Alphaproteobacteria; o_; f_; g —   
                 43 
               
               
                 k_Bacteria; p_Proteobacteria; c_Alphaproteobacteria; o_RF32; f_; g —   
                 44 
               
               
                 k_Bacteria; p_Proteobacteria; c_Betaproteobacteria; o_Burkholderiales; 
                 45 
               
               
                 f_Alcaligenaceae; g_ Sutterella   
               
               
                 k_Bacteria; p_Proteobacteria; c_Deltaproteobacteria; o_Desulfovibrionales; 
                 46 
               
               
                 f_Desulfovibrionaceae; g —   
               
               
                 k_Bacteria; p_Proteobacteria; c_Deltaproteobacteria; o_Desulfovibrionales; 
                 47 
               
               
                 f_Desulfovibrionaceae; g_ Bilophila   
               
               
                 k_Bacteria; p_Proteobacteria; c_Deltaproteobacteria; o_Desulfovibrionales; 
                 48 
               
               
                 f_Desulfovibrionaceae; g_ Desulfovibrio   
               
               
                 k_Bacteria; p_Proteobacteria; c_Epsilonproteobacteria; o_Campylobacterales; 
                 49 
               
               
                 f_Helicobacteraceae; Other 
               
               
                 k_Bacteria; p_Proteobacteria; c_Epsilonproteobacteria; o_Campylobacterales; 
                 50 
               
               
                 f_Helicobacteraceae; g_ Flexispira   
               
               
                 k_Bacteria; p_Proteobacteria; c_Epsilonproteobacteria; o_Campylobacterales; 
                 51 
               
               
                 f_Helicobacteraceae; g_ Helicobacter   
               
               
                 k_Bacteria; p_Proteobacteria; c_Gammaproteobacteria; o_Enterobacteriales; 
                 52 
               
               
                 f_Enterobacteriaceae; g —   
               
               
                 k_Bacteria; p_Tenericutes; c_Mollicutes; o_Anaeroplasmatales; 
                 53 
               
               
                 f_Anaeroplasmataceae; g_ Anaeroplasma   
               
               
                 k_Bacteria; p_Tenericutes; c_Mollicutes; o_RF39; f_; g —   
                 54 
               
               
                 k_Bacteria; p_Verrucomicrobia; c_Verrucomicrobiae; o_Verrucomicrobiales; 
                 55 
               
               
                 f_Verrucomicrobiaceae; g_ Akkermansia   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 3B 
               
               
                   
               
               
                 No 
                 BD1 
                 BD2 
                 BD3 
                 BD4 
                 BD5 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1 
                 0.000041 
                 0.000115 
                 0.000110 
                 0.000125 
                 0.000145 
               
               
                 2 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 3 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 4 
                 0.913785 
                 0.965081 
                 0.959434 
                 0.961139 
                 0.962127 
               
               
                 5 
                 0.000000 
                 0.000000 
                 0.000024 
                 0.000010 
                 0.000026 
               
               
                 6 
                 0.000027 
                 0.000012 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 7 
                 0.000014 
                 0.000023 
                 0.000024 
                 0.000010 
                 0.000043 
               
               
                 8 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 9 
                 0.000027 
                 0.000058 
                 0.000110 
                 0.000042 
                 0.000120 
               
               
                 10 
                 0.000000 
                 0.000000 
                 0.000012 
                 0.000000 
                 0.000000 
               
               
                 11 
                 0.000082 
                 0.000023 
                 0.000049 
                 0.000031 
                 0.000009 
               
               
                 12 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 13 
                 0.000000 
                 0.000012 
                 0.000000 
                 0.000010 
                 0.000009 
               
               
                 14 
                 0.000014 
                 0.000058 
                 0.000000 
                 0.001190 
                 0.000026 
               
               
                 15 
                 0.000219 
                 0.000230 
                 0.000085 
                 0.000177 
                 0.000060 
               
               
                 16 
                 0.000027 
                 0.000035 
                 0.000049 
                 0.000000 
                 0.000009 
               
               
                 17 
                 0.000260 
                 0.000219 
                 0.000329 
                 0.000282 
                 0.000273 
               
               
                 18 
                 0.001532 
                 0.000622 
                 0.000268 
                 0.000480 
                 0.000316 
               
               
                 19 
                 0.000315 
                 0.000219 
                 0.000097 
                 0.000136 
                 0.000111 
               
               
                 20 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 21 
                 0.001177 
                 0.000426 
                 0.000134 
                 0.000334 
                 0.000333 
               
               
                 22 
                 0.000219 
                 0.000092 
                 0.000061 
                 0.000084 
                 0.000077 
               
               
                 23 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 24 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 25 
                 0.000014 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 26 
                 0.000575 
                 0.000703 
                 0.000000 
                 0.000731 
                 0.000265 
               
               
                 27 
                 0.000698 
                 0.000346 
                 0.000304 
                 0.000198 
                 0.000171 
               
               
                 28 
                 0.016841 
                 0.008710 
                 0.007124 
                 0.005543 
                 0.006968 
               
               
                 29 
                 0.005062 
                 0.002431 
                 0.000146 
                 0.002025 
                 0.000837 
               
               
                 30 
                 0.000014 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 31 
                 0.000000 
                 0.000012 
                 0.000012 
                 0.000000 
                 0.000009 
               
               
                 32 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 33 
                 0.000465 
                 0.000184 
                 0.000256 
                 0.000261 
                 0.000239 
               
               
                 34 
                 0.046952 
                 0.013779 
                 0.013907 
                 0.016732 
                 0.015354 
               
               
                 35 
                 0.000014 
                 0.000012 
                 0.000000 
                 0.000021 
                 0.000009 
               
               
                 36 
                 0.000014 
                 0.000012 
                 0.000000 
                 0.000010 
                 0.000017 
               
               
                 37 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 38 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 39 
                 0.000000 
                 0.000012 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 40 
                 0.000055 
                 0.000012 
                 0.000049 
                 0.000000 
                 0.000026 
               
               
                 41 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 42 
                 0.002709 
                 0.001682 
                 0.003629 
                 0.001054 
                 0.000666 
               
               
                 43 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 44 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 45 
                 0.000000 
                 0.000000 
                 0.000012 
                 0.000000 
                 0.000000 
               
               
                 46 
                 0.000000 
                 0.000012 
                 0.000000 
                 0.000000 
                 0.000017 
               
               
                 47 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 48 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 49 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 50 
                 0.000027 
                 0.000000 
                 0.000024 
                 0.000042 
                 0.000009 
               
               
                 51 
                 0.000014 
                 0.000000 
                 0.000000 
                 0.000010 
                 0.000017 
               
               
                 52 
                 0.008797 
                 0.004862 
                 0.013749 
                 0.009280 
                 0.011716 
               
               
                 53 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000010 
                 0.000000 
               
               
                 54 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
                 0.000000 
               
               
                 55 
                 0.000014 
                 0.000012 
                 0.000000 
                 0.000031 
                 0.000000 
               
               
                   
               
            
           
         
       
     
     Example 8: Table 4 for Examples 1-3, Provided as Parts Tables 4A Through 4E 
     Tables 4A through 4E (collectively “Table 4”) relate to metabolites in E14.5 SPF, ABX, GF, and Sp fetal brains. The cells can be classified from the given data based on p&lt;0.05 or 0.05&lt;p&lt;0.10, as well as based on the mean values being significantly higher or not for each comparison. PSO stands for pathway sort order. Table 4C provides “fold of change,” in which columns 2 through 7 are the ANOVA contrasts, and the “GE” is group effect for one-way ANOVA. The ANOVA contrasts are further provided in Tables 4D and 4E. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 4A 
               
               
                   
               
               
                 PSO 
                 Super Pathway 
                 Sub Pathway 
                 Biochemical Name 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 1 
                 Amino_Acid 
                 Glycine, Serine and 
                 glycine 
               
               
                 2 
                   
                 Threonine Metabolism 
                 N-acetylglycine 
               
               
                 5 
                   
                   
                 dimethylglycine 
               
               
                 6 
                   
                   
                 betaine 
               
               
                 9 
                   
                   
                 serine 
               
               
                 10 
                   
                   
                 N-acetylserine 
               
               
                 14 
                   
                   
                 3-phosphoserine 
               
               
                 16 
                   
                   
                 threonine 
               
               
                 17 
                   
                   
                 N-acetylthreonine 
               
               
                 18 
                   
                   
                 allo-threonine 
               
               
                 21 
                   
                   
                 homoserine 
               
               
                 28 
                   
                 Alanine and Aspartate 
                 alanine 
               
               
                 30 
                   
                 Metabolism 
                 N-acetylalanine 
               
               
                 34 
                   
                   
                 aspartate 
               
               
                 35 
                   
                   
                 N-acetylaspartate (NAA) 
               
               
                 38 
                   
                   
                 asparagine 
               
               
                 39 
                   
                   
                 N-acetylasparagine 
               
               
                 40 
                   
                   
                 hydroxyasparagine** 
               
               
                 41 
                   
                 Glutamate Metabolism 
                 glutamate 
               
               
                 42 
                   
                   
                 glutamine 
               
               
                 43 
                   
                   
                 alpha-ketoglutaramate* 
               
               
                 44 
                   
                   
                 N-acetylglutamate 
               
               
                 45 
                   
                   
                 N-acetylglutamine 
               
               
                 47 
                   
                   
                 4-hydroxyglutamate 
               
               
                 50 
                   
                   
                 glutamate, gamma-methyl ester 
               
               
                 51 
                   
                   
                 pyroglutamine* 
               
               
                 52 
                   
                   
                 N-acetyl-aspartyl-glutamate (NAAG) 
               
               
                 53 
                   
                   
                 beta-citrylglutamate 
               
               
                 54 
                   
                   
                 gamma-aminobutyrate (GABA) 
               
               
                 55 
                   
                   
                 carboxyethyl-GABA 
               
               
                 56 
                   
                   
                 N-methyl-GABA 
               
               
                 59 
                   
                   
                 S-1-pyrroline-5-carboxylate 
               
               
                 65 
                   
                 Histidine Metabolism 
                 histidine 
               
               
                 66 
                   
                   
                 1-methylhistidine 
               
               
                 67 
                   
                   
                 3-methylhistidine 
               
               
                 68 
                   
                   
                 N-acetylhistidine 
               
               
                 74 
                   
                   
                 imidazole propionate 
               
               
                 75 
                   
                   
                 formiminoglutamate 
               
               
                 76 
                   
                   
                 imidazole lactate 
               
               
                 77 
                   
                   
                 carnosine 
               
               
                 80 
                   
                   
                 anserine 
               
               
                 82 
                   
                   
                 1-methylhistamine 
               
               
                 83 
                   
                   
                 1-methyl-4-imidazoleacetate 
               
               
                 84 
                   
                   
                 1-ribosyl-imidazoleacetate* 
               
               
                 92 
                   
                 Lysine Metabolism 
                 lysine 
               
               
                 93 
                   
                   
                 N2-acetyllysine 
               
               
                 99 
                   
                   
                 N6-methyllysine 
               
               
                 100 
                   
                   
                 N6,N6-dimethyllysine 
               
               
                 101 
                   
                   
                 N6,N6,N6-trimethyllysine 
               
               
                 102 
                   
                   
                 5-hydroxylysine 
               
               
                 103 
                   
                   
                 5-(galactosylhydroxy)-L-lysine 
               
               
                 105 
                   
                   
                 2-aminoadipate 
               
               
                 107 
                   
                   
                 2-oxoadipate 
               
               
                 113 
                   
                   
                 pipecolate 
               
               
                 114 
                   
                   
                 6-oxopiperidine-2-carboxylate 
               
               
                 117 
                   
                   
                 5-aminovalerate 
               
               
                 119 
                   
                   
                 N,N,N-trimethyl-5-aminovalerate 
               
               
                 120 
                   
                 Phenylalanine 
                 phenylalanine 
               
               
                 121 
                   
                 Metabolism 
                 N-acetylphenylalanine 
               
               
                 122 
                   
                   
                 1-carboxyethylphenylalanine 
               
               
                 126 
                   
                   
                 phenyllactate (PLA) 
               
               
                 137 
                   
                 Tyrosine Metabolism 
                 tyrosine 
               
               
                 138 
                   
                   
                 N-acetyltyrosine 
               
               
                 150 
                   
                   
                 3-(4-hydroxyphenyl)lactate 
               
               
                 154 
                   
                   
                 phenol sulfate 
               
               
                 180 
                   
                   
                 o-Tyrosine 
               
               
                 181 
                   
                   
                 O-methyltyrosine 
               
               
                 191 
                   
                   
                 N-formylphenylalanine 
               
               
                 210 
                   
                 Tryptophan Metabolism 
                 tryptophan 
               
               
                 217 
                   
                   
                 C-glycosyltryptophan 
               
               
                 221 
                   
                   
                 kynurenine 
               
               
                 227 
                   
                   
                 N-formylanthranilic acid 
               
               
                 241 
                   
                   
                 indolelactate 
               
               
                 254 
                   
                   
                 3-indoxyl sulfate 
               
               
                 261 
                   
                 Leucine, Isoleucine and 
                 leucine 
               
               
                 263 
                   
                 Valine Metabolism 
                 1-carboxyethylleucine 
               
               
                 265 
                   
                   
                 4-methyl-2-oxopentanoate 
               
               
                 273 
                   
                   
                 isovalerylcarnitine (C5) 
               
               
                 280 
                   
                   
                 beta-hydroxyisovalerate 
               
               
                 296 
                   
                   
                 isoleucine 
               
               
                 299 
                   
                   
                 1-carboxyethylisoleucine 
               
               
                 300 
                   
                   
                 3-methyl-2-oxovalerate 
               
               
                 301 
                   
                   
                 alpha-hydroxyisovalerate 
               
               
                 303 
                   
                   
                 2-methylbutyrylcarnitine (C5) 
               
               
                 306 
                   
                   
                 tiglylcarnitine (C5:1-DC) 
               
               
                 311 
                   
                   
                 ethylmalonate 
               
               
                 312 
                   
                   
                 methylsuccinate 
               
               
                 318 
                   
                   
                 valine 
               
               
                 321 
                   
                   
                 1-carboxyethylvaline 
               
               
                 323 
                   
                   
                 3-methyl-2-oxobutyrate 
               
               
                 326 
                   
                   
                 isobutyrylcarnitine (C4) 
               
               
                 328 
                   
                   
                 3-hydroxyisobutyrate 
               
               
                 332 
                   
                 Methionine, Cysteine, 
                 methionine 
               
               
                 333 
                   
                 SAM and Taurine 
                 N-acetylmethionine 
               
               
                 334 
                   
                 Metabolism 
                 N-formylmethionine 
               
               
                 337 
                   
                   
                 methionine sulfoxide 
               
               
                 342 
                   
                   
                 S-adenosylmethionine (SAM) 
               
               
                 343 
                   
                   
                 S-adenosylhomocysteine (SAH) 
               
               
                 349 
                   
                   
                 cystathionine 
               
               
                 351 
                   
                   
                 cysteine 
               
               
                 353 
                   
                   
                 S-methylcysteine 
               
               
                 362 
                   
                   
                 cysteine sulfinic acid 
               
               
                 363 
                   
                   
                 hypotaurine 
               
               
                 364 
                   
                   
                 taurine 
               
               
                 365 
                   
                   
                 N-acetyltaurine 
               
               
                 367 
                   
                   
                 taurocyamine 
               
               
                 369 
                   
                   
                 3-sulfo-L-alanine 
               
               
                 371 
                   
                 Urea cycle; Arginine 
                 arginine 
               
               
                 372 
                   
                 and Proline Metabolism 
                 argininosuccinate 
               
               
                 373 
                   
                   
                 urea 
               
               
                 375 
                   
                   
                 ornithine 
               
               
                 379 
                   
                   
                 2-oxoarginine* 
               
               
                 380 
                   
                   
                 citrulline 
               
               
                 381 
                   
                   
                 homoarginine 
               
               
                 382 
                   
                   
                 homocitrulline 
               
               
                 383 
                   
                   
                 proline 
               
               
                 386 
                   
                   
                 dimethylarginine (SDMA + ADMA) 
               
               
                 387 
                   
                   
                 N-acetylarginine 
               
               
                 392 
                   
                   
                 N-delta-acetylornithine 
               
               
                 397 
                   
                   
                 trans-4-hydroxyproline 
               
               
                 399 
                   
                   
                 pro-hydroxy-pro 
               
               
                 405 
                   
                   
                 argininate* 
               
               
                 410 
                   
                 Creatine Metabolism 
                 guanidinoacetate 
               
               
                 411 
                   
                   
                 creatine 
               
               
                 412 
                   
                   
                 creatinine 
               
               
                 418 
                   
                 Polyamine Metabolism 
                 putrescine 
               
               
                 421 
                   
                   
                 spermidine 
               
               
                 426 
                   
                   
                 spermine 
               
               
                 429 
                   
                   
                 5-methylthioadenosine (MTA) 
               
               
                 430 
                   
                   
                 N-acetylputrescine 
               
               
                 436 
                   
                   
                 (N(1) + N(8))-acetylspermidine 
               
               
                 438 
                   
                 Guanidino and Acetamido 
                 1-methylguanidine 
               
               
                 439 
                   
                 Metabolism 
                 4-guanidinobutanoate 
               
               
                 442 
                   
                 Glutathione Metabolism 
                 glutathione, reduced (GSH) 
               
               
                 443 
                   
                   
                 glutathione, oxidized (GSSG) 
               
               
                 445 
                   
                   
                 cysteine-glutathione disulfide 
               
               
                 446 
                   
                   
                 S-methylglutathione 
               
               
                 447 
                   
                   
                 S-lactoylglutathione 
               
               
                 451 
                   
                   
                 5-oxoproline 
               
               
                 454 
                   
                   
                 2-hydroxybutyrate/2-hydroxyisobutyrate 
               
               
                 456 
                   
                   
                 ophthalmate 
               
               
                 459 
                   
                   
                 4-hydroxy-nonenal-glutathione 
               
               
                 460 
                   
                   
                 3′-dephospho-CoA-glutathione* 
               
               
                 461 
                   
                   
                 CoA-glutathione* 
               
               
                 465 
                 Peptide 
                 Gamma-glutamyl Amino 
                 gamma-glutamylalanine 
               
               
                 467 
                   
                 Acid 
                 gamma-glutamylglutamate 
               
               
                 468 
                   
                   
                 gamma-glutamylglutamine 
               
               
                 469 
                   
                   
                 gamma-glutamylglycine 
               
               
                 471 
                   
                   
                 gamma-glutamylisoleucine* 
               
               
                 472 
                   
                   
                 gamma-glutamylleucine 
               
               
                 473 
                   
                   
                 gamma-glutamyl-alpha-lysine 
               
               
                 474 
                   
                   
                 gamma-glutamyl-epsilon-lysine 
               
               
                 475 
                   
                   
                 gamma-glutamylmethionine 
               
               
                 476 
                   
                   
                 gamma-glutamylphenylalanine 
               
               
                 477 
                   
                   
                 gamma-glutamylthreonine 
               
               
                 478 
                   
                   
                 gamma-glutamyltryptophan 
               
               
                 479 
                   
                   
                 gamma-glutamyltyrosine 
               
               
                 480 
                   
                   
                 gamma-glutamylvaline 
               
               
                 756 
                   
                 Dipeptide 
                 prolylglycine 
               
               
                 929 
                   
                 Acetylated Peptides 
                 phenylacetylglycine 
               
               
                 955 
                 Carbohydrate 
                 Glycolysis, 
                 1,5-anhydroglucitol (1,5-AG) 
               
               
                 958 
                   
                 Gluconeogenesis, and 
                 glucose 
               
               
                 959 
                   
                 Pyruvate Metabolism 
                 glucose 6-phosphate 
               
               
                 965 
                   
                   
                 fructose 1,6-diphosphate/ 
               
               
                   
                   
                   
                 glucose 1,6-diphosphate/ 
               
               
                   
                   
                   
                 myo-inositol diphosphates 
               
               
                 967 
                   
                   
                 dihydroxyacetone phosphate (DHAP) 
               
               
                 972 
                   
                   
                 3-phosphoglycerate 
               
               
                 973 
                   
                   
                 phosphoenolpyruvate (PEP) 
               
               
                 974 
                   
                   
                 pyruvate 
               
               
                 975 
                   
                   
                 lactate 
               
               
                 978 
                   
                   
                 glycerate 
               
               
                 981 
                   
                 Pentose Phosphate 
                 6-phosphogluconate 
               
               
                 982 
                   
                 Pathway 
                 ribulose 5-phosphate 
               
               
                 983 
                   
                   
                 ribose 5-phosphate 
               
               
                 984 
                   
                   
                 ribose 1-phosphate 
               
               
                 986 
                   
                   
                 sedoheptulose-7-phosphate 
               
               
                 993 
                   
                 Pentose Metabolism 
                 ribose 
               
               
                 994 
                   
                   
                 ribitol 
               
               
                 995 
                   
                   
                 ribonate 
               
               
                 997 
                   
                   
                 xylulose 5-phosphate 
               
               
                 1018 
                   
                   
                 arabitol/xylitol 
               
               
                 1020 
                   
                   
                 arabonate/xylonate 
               
               
                 1023 
                   
                   
                 sedoheptulose 
               
               
                 1024 
                   
                   
                 ribulonate/xylulonate* 
               
               
                 1028 
                   
                 Glycogen Metabolism 
                 maltotetraose 
               
               
                 1030 
                   
                   
                 maltotriose 
               
               
                 1033 
                   
                   
                 maltose 
               
               
                 1073 
                   
                 Fructose, Mannose and 
                 fructose 
               
               
                 1078 
                   
                 Galactose Metabolism 
                 mannitol/sorbitol 
               
               
                 1079 
                   
                   
                 mannose 
               
               
                 1080 
                   
                   
                 mannose-6-phosphate 
               
               
                 1090 
                   
                   
                 galactose 1-phosphate 
               
               
                 1099 
                   
                   
                 galactonate 
               
               
                 1104 
                   
                 Nucleotide Sugar 
                 UDP-glucose 
               
               
                 1108 
                   
                   
                 UDP-galactose 
               
               
                 1109 
                   
                   
                 UDP-glucuronate 
               
               
                 1111 
                   
                   
                 guanosine 5′-diphospho-fucose 
               
               
                 1115 
                   
                   
                 UDP-N-acetylglucosamine/galactosamine 
               
               
                 1116 
                   
                   
                 cytidine 5′-monophospho-N- 
               
               
                   
                   
                   
                 acetylneuraminic acid 
               
               
                 1123 
                   
                 Aminosugar Metabolism 
                 glucosamine-6-phosphate 
               
               
                 1127 
                   
                   
                 glucuronate 
               
               
                 1131 
                   
                   
                 N-acetylglucosamine 6-phosphate 
               
               
                 1132 
                   
                   
                 N-acetyl-glucosamine 1-phosphate 
               
               
                 1138 
                   
                   
                 N-acetylneuraminate 
               
               
                 1149 
                   
                   
                 N-acetylglucosaminylasparagine 
               
               
                 1150 
                   
                   
                 erythronate* 
               
               
                 1152 
                   
                   
                 N-acetylglucosamine/ 
               
               
                   
                   
                   
                 N-acetylgalactosamine 
               
               
                 1157 
                 Energy 
                 TCA Cycle 
                 citrate 
               
               
                 1163 
                   
                   
                 alpha-ketoglutarate 
               
               
                 1165 
                   
                   
                 succinylcarnitine (C4-DC) 
               
               
                 1166 
                   
                   
                 succinate 
               
               
                 1167 
                   
                   
                 fumarate 
               
               
                 1169 
                   
                   
                 malate 
               
               
                 1179 
                   
                   
                 2-methylcitrate/homocitrate 
               
               
                 1181 
                   
                 Oxidative 
                 acetylphosphate 
               
               
                 1183 
                   
                 Phosphorylation 
                 phosphate 
               
               
                 1201 
                 Lipid 
                 Medium Chain Fatty Acid 
                 caproate (6:0) 
               
               
                 1203 
                   
                   
                 caprylate (8:0) 
               
               
                 1204 
                   
                   
                 pelargonate (9:0) 
               
               
                 1205 
                   
                   
                 caprate (10:0) 
               
               
                 1217 
                   
                 Long Chain Fatty Acid 
                 palmitate (16:0) 
               
               
                 1218 
                   
                   
                 palmitoleate (16:1n7) 
               
               
                 1223 
                   
                   
                 stearate (18:0) 
               
               
                 1225 
                   
                   
                 oleate/vaccenate (18:1) 
               
               
                 1236 
                   
                   
                 arachidate (20:0) 
               
               
                 1239 
                   
                   
                 eicosenoate (20:1) 
               
               
                 1244 
                   
                   
                 erucate (22:1n9) 
               
               
                 1247 
                   
                   
                 nervonate (24:1n9)* 
               
               
                 1253 
                   
                 Polyunsaturated Fatty 
                 hexadecadienoate (16:2n6) 
               
               
                 1258 
                   
                 Acid (n3 and n6) 
                 eicosapentaenoate (EPA; 20:5n3) 
               
               
                 1259 
                   
                   
                 docosapentaenoate (n3 DPA; 22:5n3) 
               
               
                 1260 
                   
                   
                 docosahexaenoate (DHA; 22:6n3) 
               
               
                 1264 
                   
                   
                 nisinate (24:6n3) 
               
               
                 1265 
                   
                   
                 linoleate (18:2n6) 
               
               
                 1267 
                   
                   
                 linolenate [alpha or gamma; 
               
               
                   
                   
                   
                 (18:3n3 or 6)] 
               
               
                 1269 
                   
                   
                 dihomo-linolenate (20:3n3 or n6) 
               
               
                 1270 
                   
                   
                 arachidonate (20:4n6) 
               
               
                 1271 
                   
                   
                 adrenate (22:4n6) 
               
               
                 1272 
                   
                   
                 docosapentaenoate (n6 DPA; 22:5n6) 
               
               
                 1273 
                   
                   
                 docosadienoate (22:2n6) 
               
               
                 1274 
                   
                   
                 dihomo-linoleate (20:2n6) 
               
               
                 1276 
                   
                   
                 mead acid (20:3n9) 
               
               
                 1277 
                   
                   
                 docosatrienoate (22:3n6)* 
               
               
                 1351 
                   
                 Fatty Acid, 
                 glutarate (C5-DC) 
               
               
                 1355 
                   
                 Dicarboxylate 
                 2-hydroxyglutarate 
               
               
                 1359 
                   
                   
                 2-hydroxyadipate 
               
               
                 1360 
                   
                   
                 3-hydroxyadipate* 
               
               
                 1363 
                   
                   
                 maleate 
               
               
                 1372 
                   
                   
                 sebacate (C10-DC) 
               
               
                 1430 
                   
                 Fatty Acid, Amino 
                 2-aminoheptanoate 
               
               
                 1446 
                   
                 Fatty Acid Metabolism 
                 butyrylcarnitine (C4) 
               
               
                 1449 
                   
                 (also BCAA Metabolism) 
                 propionylcarnitine (C3) 
               
               
                 1452 
                   
                   
                 methylmalonate (MMA) 
               
               
                 1480 
                   
                 Fatty Acid 
                 acetylcarnitine (C2) 
               
               
                 1482 
                   
                 Metabolism(Acyl 
                 3-hydroxybutyrylcarnitine (1) 
               
               
                 1483 
                   
                 Carnitine) 
                 3-hydroxybutyrylcarnitine (2) 
               
               
                 1485 
                   
                   
                 hexanoylcarnitine (C6) 
               
               
                 1487 
                   
                   
                 3-hydroxyhexanoylcarnitine (1) 
               
               
                 1488 
                   
                   
                 octanoylcarnitine (C8) 
               
               
                 1495 
                   
                   
                 laurylcarnitine (C12) 
               
               
                 1496 
                   
                   
                 myristoylcarnitine (C14) 
               
               
                 1498 
                   
                   
                 palmitoylcarnitine (C16) 
               
               
                 1499 
                   
                   
                 palmitoleoylcarnitine (C16:1)* 
               
               
                 1500 
                   
                   
                 stearoylcarnitine (C18) 
               
               
                 1501 
                   
                   
                 linoleoylcarnitine (C18:2)* 
               
               
                 1503 
                   
                   
                 3-hydroxyoleoylcarnitine 
               
               
                 1504 
                   
                   
                 oleoylcarnitine (C18:1) 
               
               
                 1506 
                   
                   
                 myristoleoylcarnitine (C14:1)* 
               
               
                 1517 
                   
                   
                 arachidoylcarnitine (C20)* 
               
               
                 1518 
                   
                   
                 arachidonoylcarnitine (C20:4) 
               
               
                 1519 
                   
                   
                 adrenoylcarnitine (C22:4)* 
               
               
                 1521 
                   
                   
                 meadoylcarnitine (C20:3n9)* 
               
               
                 1522 
                   
                   
                 dihomo-linolenoylcarnitine (C20:3n3 or 6)* 
               
               
                 1523 
                   
                   
                 dihomo-linoleoylcarnitine (C20:2)* 
               
               
                 1524 
                   
                   
                 eicosenoylcarnitine (C20:1)* 
               
               
                 1527 
                   
                   
                 docosatrienoylcarnitine (C22:3)* 
               
               
                 1528 
                   
                   
                 docosapentaenoylcarnitine (C22:5n3)* 
               
               
                 1529 
                   
                   
                 docosahexaenoylcarnitine (C22:6)* 
               
               
                 1536 
                   
                   
                 pentadecanoylcarnitine (C15)* 
               
               
                 1537 
                   
                   
                 docosapentaenoylcarnitine (C22:5n6)* 
               
               
                 1539 
                   
                   
                 3-hydroxypalmitoylcarnitine 
               
               
                 1541 
                   
                 Carnitine Metabolism 
                 deoxycarnitine 
               
               
                 1542 
                   
                   
                 carnitine 
               
               
                 1547 
                   
                 Ketone Bodies 
                 3-hydroxybutyrate (BHBA) 
               
               
                 1565 
                   
                 Fatty Acid, Monohydroxy 
                 2-hydroxyheptanoate* 
               
               
                 1567 
                   
                   
                 2-hydroxydecanoate 
               
               
                 1582 
                   
                   
                 3-hydroxydecanoate 
               
               
                 1711 
                   
                 Eicosanoid 
                 12-HHTrE 
               
               
                 1718 
                   
                 Endocannabinoid 
                 oleoyl ethanolamide 
               
               
                 1721 
                   
                   
                 palmitoyl ethanolamide 
               
               
                 1731 
                   
                   
                 N-stearoyltaurine 
               
               
                 1732 
                   
                   
                 N-palmitoyltaurine 
               
               
                 1744 
                   
                   
                 palmitoleoyl ethanolamide* 
               
               
                 1753 
                   
                 Inositol Metabolism 
                 myo-inositol 
               
               
                 1754 
                   
                   
                 chiro-inositol 
               
               
                 1782 
                   
                 Phospholipid Metabolism 
                 choline 
               
               
                 1783 
                   
                   
                 choline phosphate 
               
               
                 1784 
                   
                   
                 cytidine 5′-diphosphocholine 
               
               
                 1786 
                   
                   
                 glycerophosphorylcholine (GPC) 
               
               
                 1788 
                   
                   
                 phosphoethanolamine 
               
               
                 1789 
                   
                   
                 cytidine-5′-diphosphoethanolamine 
               
               
                 1790 
                   
                   
                 glycerophosphoethanolamine 
               
               
                 1791 
                   
                   
                 glycerophosphoserine* 
               
               
                 1792 
                   
                   
                 glycerophosphoinositol* 
               
               
                 1793 
                   
                   
                 trimethylamine N-oxide 
               
               
                 1811 
                   
                 Phosphatidylcholine 
                 1-myristoyl-2-palmitoyl-GPC (14:0/16:0) 
               
               
                 1815 
                   
                 (PC) 
                 1-myristoyl-2-arachidonoyl-GPC (14:0/20:4)* 
               
               
                 1827 
                   
                   
                 1,2-dipalmitoyl-GPC (16:0/16:0) 
               
               
                 1828 
                   
                   
                 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1)* 
               
               
                 1829 
                   
                   
                 1-palmitoyl-2-stearoyl-GPC (16:0/18:0) 
               
               
                 1831 
                   
                   
                 1-palmitoyl-2-oleoyl-GPC (16:0/18:1) 
               
               
                 1834 
                   
                   
                 1-palmitoyl-2-linoleoyl-GPC (16:0/18:2) 
               
               
                 1837 
                   
                   
                 1-palmitoyl-2-gamma-linolenoyl-GPC (16:0/18:3n6)* 
               
               
                 1841 
                   
                   
                 1-palmitoyl-2-dihomo-linolenoyl-GPC (16:0/20:3n3 or 6)* 
               
               
                 1845 
                   
                   
                 1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6) 
               
               
                 1851 
                   
                   
                 1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6) 
               
               
                 1866 
                   
                   
                 1,2-distearoyl-GPC (18:0/18:0) 
               
               
                 1867 
                   
                   
                 1-stearoyl-2-oleoyl-GPC (18:0/18:1) 
               
               
                 1870 
                   
                   
                 1-stearoyl-2-linoleoyl-GPC (18 :0/18:2)* 
               
               
                 1878 
                   
                   
                 1-stearoyl-2-arachidonoyl-GPC (18:0/20:4) 
               
               
                 1884 
                   
                   
                 1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6) 
               
               
                 1889 
                   
                   
                 1,2-dioleoyl-GPC (18:1/18:1) 
               
               
                 1892 
                   
                   
                 1-oleoyl-2-linoleoyl-GPC (18:1/18:2)* 
               
               
                 1902 
                   
                   
                 1-oleoyl-2-docosahexaenoyl-GPC (18:1/22:6)* 
               
               
                 1903 
                   
                   
                 1,2-dilinoleoyl-GPC (18:2/18:2) 
               
               
                 1907 
                   
                   
                 1-linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6)* 
               
               
                 1945 
                   
                 Phosphatidylethanolamine 
                 1,2-dipalmitoyl-GPE (16:0/16:0)* 
               
               
                 1948 
                   
                 (PE) 
                 1-palmitoyl-2-stearoyl-GPE (16:0/18:0)* 
               
               
                 1949 
                   
                   
                 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) 
               
               
                 1950 
                   
                   
                 1-palmitoyl-2-linoleoyl-GPE (16:0/18:2) 
               
               
                 1953 
                   
                   
                 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4)* 
               
               
                 1955 
                   
                   
                 1-palmitoyl-2-docosahexaenoyl-GPE (16:0/22:6)* 
               
               
                 1962 
                   
                   
                 1-stearoyl-2-oleoyl-GPE (18:0/18:1) 
               
               
                 1970 
                   
                   
                 1-stearoyl-2-arachidonoyl-GPE (18:0/20:4) 
               
               
                 1974 
                   
                   
                 1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6)* 
               
               
                 1975 
                   
                   
                 1,2-dioleoyl-GPE (18:1/18:1) 
               
               
                 1976 
                   
                   
                 1-oleoyl-2-linoleoyl-GPE (18:1/18:2)* 
               
               
                 1979 
                   
                   
                 1-oleoyl-2-arachidonoyl-GPE (18:1/20:4)* 
               
               
                 1982 
                   
                   
                 1-oleoyl-2-docosahexaenoyl-GPE (18:1/22:6)* 
               
               
                 1985 
                   
                   
                 1-linoleoyl-2-arachidonoyl-GPE (18:2/20:4)* 
               
               
                 2016 
                   
                 Phosphatidylserine (PS) 
                 1-palmitoyl-2-oleoyl-GPS (16:0/18:1) 
               
               
                 2021 
                   
                   
                 1-stearoyl-2-oleoyl-GPS (18:0/18:1) 
               
               
                 2024 
                   
                   
                 1-stearoyl-2-arachidonoyl-GPS (18:0/20:4) 
               
               
                 2034 
                   
                 Phosphatidylglycerol 
                 1-palmitoyl-2-oleoyl-GPG (16:0/18:1) 
               
               
                   
                   
                 (PG) 
               
               
                 2052 
                   
                 Phosphatidylinositol 
                 1-palmitoyl-2-arachidonoyl-GPI (16:0/20:4)* 
               
               
                 2067 
                   
                 (PI) 
                 1-stearoyl-2-arachidonoyl-GPI (18:0/20:4) 
               
               
                 2072 
                   
                   
                 1-oleoyl-2-arachidonoyl-GPI (18:1/20:4)* 
               
               
                 2105 
                   
                 Lysophospholipid 
                 1-palmitoyl-GPC (16:0) 
               
               
                 2106 
                   
                   
                 2-palmitoyl-GPC (16:0)* 
               
               
                 2107 
                   
                   
                 1-palmitoleoyl-GPC (16:1)* 
               
               
                 2113 
                   
                   
                 1-stearoyl-GPC (18:0) 
               
               
                 2115 
                   
                   
                 1-oleoyl-GPC (18:1) 
               
               
                 2118 
                   
                   
                 1-linoleoyl-GPC (18:2) 
               
               
                 2136 
                   
                   
                 1-arachidonoyl-GPC (20:4n6)* 
               
               
                 2157 
                   
                   
                 1-palmitoyl-GPE (16:0) 
               
               
                 2164 
                   
                   
                 1-stearoyl-GPE (18:0) 
               
               
                 2165 
                   
                   
                 2-stearoyl-GPE (18:0)* 
               
               
                 2166 
                   
                   
                 1-oleoyl-GPE (18:1) 
               
               
                 2168 
                   
                   
                 1-linoleoyl-GPE (18:2)* 
               
               
                 2179 
                   
                   
                 1-arachidonoyl-GPE (20:4n6)* 
               
               
                 2192 
                   
                   
                 1-palmitoyl-GPS (16:0)* 
               
               
                 2193 
                   
                   
                 1-stearoyl-GPS (18:0)* 
               
               
                 2194 
                   
                   
                 1-oleoyl-GPS (18:1) 
               
               
                 2199 
                   
                   
                 1-palmitoyl-GPG (16:0)* 
               
               
                 2203 
                   
                   
                 1-oleoyl-GPG (18:1)* 
               
               
                 2206 
                   
                   
                 1-palmitoyl-GPI (16:0) 
               
               
                 2209 
                   
                   
                 1-stearoyl-GPI (18:0) 
               
               
                 2211 
                   
                   
                 1-oleoyl-GPI (18:1)* 
               
               
                 2217 
                   
                   
                 1-arachidonoyl-GPI (20:4)* 
               
               
                 2310 
                   
                 Plasmalogen 
                 1-(1-enyl-palmitoyl)-2-oleoyl-GPE (P-16:0/18:1)* 
               
               
                 2311 
                   
                   
                 1-(1-enyl-palmitoyl)-2-linoleoyl-GPE (P-16:0/18:2)* 
               
               
                 2312 
                   
                   
                 1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0)* 
               
               
                 2313 
                   
                   
                 1-(1-enyl-palmitoyl)-2-palmitoleoyl-GPC (P-16:0/16:1)* 
               
               
                 2314 
                   
                   
                 1-(1-enyl-palmitoyl)-2-arachidonoyl-GPE (P-16:0/20:4)* 
               
               
                 2318 
                   
                   
                 1-(1-enyl-stearoyl)-2-oleoyl-GPE (P-18:0/18:1) 
               
               
                 2327 
                   
                   
                 1-(1-enyl-stearoyl)-2-arachidonoyl-GPE (P-18:0/20:4)* 
               
               
                 2343 
                   
                 Lysoplasmalogen 
                 1-(1-enyl-palmitoyl)-GPE (P-16:0)* 
               
               
                 2345 
                   
                   
                 1-(1-enyl-oleoyl)-GPE (P-18:1)* 
               
               
                 2347 
                   
                   
                 1-(1-enyl-stearoyl)-GPE (P-18:0)* 
               
               
                 2348 
                   
                   
                 1-(1-enyl-oleoyl)-2-oleoyl-GPE (P-18:1/18:1)* 
               
               
                 2350 
                   
                 Glycerolipid Metabolism 
                 glycerol 
               
               
                 2351 
                   
                   
                 glycerol 3-phosphate 
               
               
                 2356 
                   
                   
                 glycerophosphoglycerol 
               
               
                 2357 
                   
                 Monoacylglycerol 
                 1-myristoylglycerol (14:0) 
               
               
                 2360 
                   
                   
                 1-palmitoylglycerol (16:0) 
               
               
                 2361 
                   
                   
                 1-palmitoleoylglycerol (16:1)* 
               
               
                 2364 
                   
                   
                 1-oleoylglycerol (18:1) 
               
               
                 2371 
                   
                   
                 1-arachidonylglycerol (20:4) 
               
               
                 2374 
                   
                   
                 1-docosahexaenoylglycerol (22:6) 
               
               
                 2375 
                   
                   
                 2-myristoylglycerol (14:0) 
               
               
                 2376 
                   
                   
                 2-palmitoylglycerol (16:0) 
               
               
                 2379 
                   
                   
                 2-oleoylglycerol (18:1) 
               
               
                 2381 
                   
                   
                 2-arachidonoylglycerol (20:4) 
               
               
                 2383 
                   
                   
                 2-docosahexaenoylglycerol (22:6)* 
               
               
                 2394 
                   
                 Diacylglycerol 
                 diacylglycerol (14:0/18:1, 16:0/16:1) [2]* 
               
               
                 2395 
                   
                   
                 diacylglycerol (16:1/18:2 [2], 16:0/18:3 [1])* 
               
               
                 2407 
                   
                   
                 palmitoyl-palmitoyl-glycerol (16:0/16:0) [2]* 
               
               
                 2411 
                   
                   
                 palmitoyl-oleoyl-glycerol (16:0/18:1) [2]* 
               
               
                 2413 
                   
                   
                 palmitoyl-linoleoyl-glycerol (16:0/18:2) [2]* 
               
               
                 2416 
                   
                   
                 palmitoleoyl-oleoyl-glycerol (16:1/18:1) [2]* 
               
               
                 2418 
                   
                   
                 palmitoy1-dihomo-linolenoyl-glycerol (16:0/20:3n3 or 6) [2]* 
               
               
                 2419 
                   
                   
                 palmitoyl-arachidonoyl-glycerol (16:0/20:4) [1]* 
               
               
                 2420 
                   
                   
                 palmitoyl-arachidonoyl-glycerol (16:0/20:4) [2]* 
               
               
                 2422 
                   
                   
                 palmitoyl-docosahexaenoyl-glycerol (16:0/22:6) [1]* 
               
               
                 2423 
                   
                   
                 palmitoyl-docosahexaenoyl-glycerol (16:0/22:6) [2]* 
               
               
                 2426 
                   
                   
                 stearoyl-linoleoyl-glycerol (18:0/18:2) [2]* 
               
               
                 2429 
                   
                   
                 oleoyl-oleoyl-glycerol (18:1/18:1) [2]* 
               
               
                 2431 
                   
                   
                 oleoyl-linoleoyl-glycerol (18:1/18:2) [1] 
               
               
                 2432 
                   
                   
                 oleoyl-linoleoyl-glycerol (18:1/18:2) [2] 
               
               
                 2442 
                   
                   
                 stearoyl-arachidonoyl-glycerol (18:0/20:4) [1]* 
               
               
                 2443 
                   
                   
                 stearoyl-arachidonoyl-glycerol (18:0/20:4) [2]* 
               
               
                 2445 
                   
                   
                 oleoyl-arachidonoyl-glycerol (18:1/20:4) [2]* 
               
               
                 2448 
                   
                   
                 stearoyl-docosahexaenoyl-glycerol (18:0/22:6) [1]* 
               
               
                 2449 
                   
                   
                 stearoyl-docosahexaenoyl-glycerol (18:0/22:6) [2]* 
               
               
                 2474 
                   
                 Sphingolipid Synthesis 
                 sphinganine 
               
               
                 2480 
                   
                 Dihydroceramides 
                 N-palmitoyl-sphinganine (d18:0/16:0) 
               
               
                 2481 
                   
                   
                 N-stearoyl-sphinganine (d18:0/18:0)* 
               
               
                 2488 
                   
                 Ceramides 
                 N-palmitoyl-sphingosine (d18:1/16:0) 
               
               
                 2491 
                   
                   
                 N-stearoyl-sphingosine (d18:1/18:0)* 
               
               
                 2493 
                   
                   
                 N-arachidoyl-sphingosine (d18:1/20:0)* 
               
               
                 2498 
                   
                   
                 N-stearoyl-sphingadienine (d18:2/18:0)* 
               
               
                 2499 
                   
                   
                 N-behenoyl-sphingadienine (d18:2/22:0)* 
               
               
                 2513 
                   
                   
                 ceramide (d18:1/14:0, d16:1/16:0)* 
               
               
                 2514 
                   
                   
                 ceramide (d18:1/17:0, d17:1/18:0)* 
               
               
                 2517 
                   
                   
                 ceramide (d16:1/24:1, d18:1/22:1)* 
               
               
                 2518 
                   
                   
                 ceramide (d18:2/24:1, d18:1/24:2)* 
               
               
                 2520 
                   
                 Hexosylceramides (HCER) 
                 glycosyl-N-stearoyl-sphinganine (d18:0/18:0)* 
               
               
                 2522 
                   
                   
                 glycosyl-N-palmitoyl-sphingosine (d18:1/16:0) 
               
               
                 2523 
                   
                   
                 glycosyl-N-stearoyl-sphingosine (d18:1/18:0) 
               
               
                 2525 
                   
                   
                 glycosyl-N-behenoyl-sphingosine (d18:1/22:0)* 
               
               
                 2543 
                   
                   
                 glycosyl ceramide (d18:1/20:0, d16:1/22:0)* 
               
               
                 2547 
                   
                   
                 glycosyl ceramide (d18:2/24:1, d18:1/24:2)* 
               
               
                 2549 
                   
                 Lactosylceramides 
                 lactosyl-N-palmitoyl-sphingosine (d18:1/16:0) 
               
               
                   
                   
                 (LCER) 
               
               
                 2561 
                   
                 Dihydrosphingomyelins 
                 palmitoyl dihydrosphingomyelin (d18:0/16:0)* 
               
               
                 2563 
                   
                   
                 sphingomyelin (d18:0/18:0, d19:0/17:0)* 
               
               
                 2564 
                   
                   
                 sphingomyelin (d18:0/20:0, d16:0/22:0)* 
               
               
                 2565 
                   
                 Sphingomyelins 
                 palmitoyl sphingomyelin (d18:1/16:0) 
               
               
                 2566 
                   
                   
                 hydroxypalmitoyl sphingomyelin (d18:1/16:0(OH))** 
               
               
                 2567 
                   
                   
                 stearoyl sphingomyelin (d18:1/18:0) 
               
               
                 2568 
                   
                   
                 behenoyl sphingomyelin (d18:1/22:0)* 
               
               
                 2569 
                   
                   
                 tricosanoyl sphingomyelin (d18:1/23:0)* 
               
               
                 2570 
                   
                   
                 lignoceroyl sphingomyelin (d18:1/24:0) 
               
               
                 2575 
                   
                   
                 sphingomyelin (d18:1/14:0, d16:1/16:0)* 
               
               
                 2577 
                   
                   
                 sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* 
               
               
                 2579 
                   
                   
                 sphingomyelin (d18:2/16:0, d18:1/16:1)* 
               
               
                 2580 
                   
                   
                 sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) 
               
               
                 2581 
                   
                   
                 sphingomyelin (d18:1/18:1, d18:2/18:0) 
               
               
                 2583 
                   
                   
                 sphingomyelin (d18:1/20:0, d16:1/22:0)* 
               
               
                 2588 
                   
                   
                 sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)* 
               
               
                 2591 
                   
                   
                 sphingomyelin (d18:1/24:1, d18:2/24:0)* 
               
               
                 2592 
                   
                   
                 sphingomyelin (d18:2/24:1, d18:1/24:2)* 
               
               
                 2594 
                   
                 Sphingosines 
                 sphingosine 
               
               
                 2610 
                   
                 Mevalonate Metabolism 
                 3-hydroxy-3-methylglutarate 
               
               
                 2624 
                   
                 Sterol 
                 desmosterol 
               
               
                 2625 
                   
                   
                 cholesterol 
               
               
                 2649 
                   
                   
                 4-cholesten-3-one 
               
               
                 2652 
                   
                   
                 campesterol 
               
               
                 2669 
                   
                   
                 7-hydroxycholesterol (alpha or beta) 
               
               
                 3453 
                 Nucleotide 
                 Purine Metabolism, 
                 inosine 5′-monophosphate (IMP) 
               
               
                 3454 
                   
                 (Hypo(Xanthine/Inosine 
                 inosine 
               
               
                 3455 
                   
                 containing 
                 hypoxanthine 
               
               
                 3456 
                   
                   
                 xanthine 
               
               
                 3458 
                   
                   
                 xanthosine 
               
               
                 3461 
                   
                   
                 N1-methylinosine 
               
               
                 3462 
                   
                   
                 2′-deoxyinosine 
               
               
                 3464 
                   
                   
                 urate 
               
               
                 3466 
                   
                   
                 allantoin 
               
               
                 3471 
                   
                 Purine Metbolism, 
                 adenosine 5′-diphosphate (ADP) 
               
               
                 3472 
                   
                 Adenine containing 
                 adenosine 5′-monophosphate (AMP) 
               
               
                 3473 
                   
                   
                 adenosine 3′-monophosphate (3′-AMP) 
               
               
                 3474 
                   
                   
                 adenosine 2′-monophosphate (2′-AMP) 
               
               
                 3478 
                   
                   
                 adenylosuccinate 
               
               
                 3479 
                   
                   
                 adenosine 
               
               
                 3480 
                   
                   
                 adenine 
               
               
                 3485 
                   
                   
                 N1-methyladenosine 
               
               
                 3495 
                   
                   
                 N6-carbamoylthreonyladenosine 
               
               
                 3498 
                   
                   
                 2′-deoxyadenosine 5′-monophosphate 
               
               
                 3505 
                   
                   
                 N6-succinyladenosine 
               
               
                 3507 
                   
                 Purine Metabolism, 
                 guanosine 5′-diphosphate (GDP) 
               
               
                 3508 
                   
                 Guanine containing 
                 guanosine 5′-monophosphate (5′-GMP) 
               
               
                 3513 
                   
                   
                 guanosine 
               
               
                 3514 
                   
                   
                 guanine 
               
               
                 3516 
                   
                   
                 7-methylguanine 
               
               
                 3522 
                   
                   
                 N2,N2-dimethylguanosine 
               
               
                 3528 
                   
                   
                 2′-deoxyguanosine 5′-monophosphate (dGMP) 
               
               
                 3530 
                   
                   
                 2′-deoxyguanosine 
               
               
                 3533 
                   
                   
                 N-carbamoylaspartate 
               
               
                 3534 
                   
                 Pyrimidine Metabolism, 
                 dihydroorotate 
               
               
                 3535 
                   
                 Orotate containing 
                 orotate 
               
               
                 3537 
                   
                   
                 orotidine 
               
               
                 3541 
                   
                 Pyrimidine Metabolism, 
                 uridine 5′-diphosphate (UDP) 
               
               
                 3542 
                   
                 Uracil containing 
                 uridine 5′-monophosphate (UMP) 
               
               
                 3547 
                   
                   
                 uridine 
               
               
                 3548 
                   
                   
                 uracil 
               
               
                 3549 
                   
                   
                 pseudouridine 
               
               
                 3550 
                   
                   
                 5,6-dihydrouridine 
               
               
                 3552 
                   
                   
                 5-methyluridine (ribothymidine) 
               
               
                 3563 
                   
                   
                 2′-deoxyuridine 
               
               
                 3565 
                   
                   
                 3-ureidoisobutyrate 
               
               
                 3566 
                   
                   
                 3-ureidopropionate 
               
               
                 3567 
                   
                   
                 beta-alanine 
               
               
                 3568 
                   
                   
                 N-acetyl-beta-alanine 
               
               
                 3572 
                   
                 Pyrimidine Metabolism, 
                 cytidine diphosphate 
               
               
                 3573 
                   
                 Cytidine containing 
                 cytidine 5′-monophosphate (5′-CMP) 
               
               
                 3576 
                   
                   
                 cytidine 2′,3′-cyclic monophosphate 
               
               
                 3577 
                   
                   
                 cytidine 
               
               
                 3578 
                   
                   
                 cytosine 
               
               
                 3579 
                   
                   
                 3-methylcytidine 
               
               
                 3580 
                   
                   
                 5-methylcytidine 
               
               
                 3585 
                   
                   
                 2′-deoxycytidine 5′-monophosphate 
               
               
                 3587 
                   
                   
                 2′-deoxycytidine 
               
               
                 3588 
                   
                   
                 2′-O-methylcytidine 
               
               
                 3589 
                   
                   
                 5-methyl-2′-deoxycytidine 
               
               
                 3598 
                   
                 Pyrimidine Metabolism, 
                 thymidine 
               
               
                 3599 
                   
                 Thymine containing 
                 thymine 
               
               
                 3602 
                   
                   
                 3-aminoisobutyrate 
               
               
                 3603 
                   
                 Purine and Pyrimidine 
                 methylphosphate 
               
               
                   
                   
                 Metabolism 
               
               
                 3607 
                   
                 Dinucleotide 
                 (3′-5′)-adenylyluridine 
               
               
                 3608 
                   
                   
                 (3′-5′)-adenylyladenosine* 
               
               
                 3624 
                 Cofactors and 
                 Nicotinate and 
                 nicotinamide 
               
               
                 3627 
                 Vitamins 
                 Nicotinamide Metabolism 
                 nicotinamide riboside 
               
               
                 3628 
                   
                   
                 nicotinamide adenine 
               
               
                   
                   
                   
                 dinucleotide (NAD+) 
               
               
                 3636 
                   
                   
                 1-methylnicotinamide 
               
               
                 3641 
                   
                   
                 trigonelline (N′-methylnicotinate) 
               
               
                 3643 
                   
                   
                 N1-Methyl-2-pyridone-5-carboxamide 
               
               
                 3644 
                   
                   
                 N1-Methyl-4-pyridone-3-carboxamide 
               
               
                 3648 
                   
                 Riboflavin Metabolism 
                 riboflavin (Vitamin B2) 
               
               
                 3649 
                   
                   
                 flavin adenine dinucleotide (FAD) 
               
               
                 3650 
                   
                   
                 flavin mononucleotide (FMN) 
               
               
                 3651 
                   
                 Pantothenate and CoA 
                 pantothenate 
               
               
                 3653 
                   
                 Metabolism 
                 phosphopantetheine 
               
               
                 3654 
                   
                   
                 3′-dephosphocoenzyme A 
               
               
                 3656 
                   
                   
                 coenzyme A 
               
               
                 3658 
                   
                   
                 pantetheine 
               
               
                 3662 
                   
                 Ascorbate and Aldarate 
                 ascorbate (Vitamin C) 
               
               
                 3663 
                   
                 Metabolism 
                 dehydroascorbate 
               
               
                 3664 
                   
                   
                 threonate 
               
               
                 3667 
                   
                   
                 oxalate (ethanedioate) 
               
               
                 3668 
                   
                   
                 gulonate* 
               
               
                 3670 
                   
                 Tocopherol Metabolism 
                 alpha-tocopherol 
               
               
                 3694 
                   
                 Biotin Metabolism 
                 biotin 
               
               
                 3698 
                   
                 Folate Metabolism 
                 5-methyltetrahydrofolate (5MeTHF) 
               
               
                 3714 
                   
                 Hemoglobin and 
                 heme 
               
               
                 3715 
                   
                 Porphyrin Metabolism 
                 bilirubin (Z,Z) 
               
               
                 3718 
                   
                   
                 biliverdin 
               
               
                 3727 
                   
                 Thiamine Metabolism 
                 thiamin (Vitamin B1) 
               
               
                 3728 
                   
                   
                 thiamin monophosphate 
               
               
                 3751 
                   
                 Vitamin B6 Metabolism 
                 pyridoxamine 
               
               
                 3754 
                   
                   
                 pyridoxal 
               
               
                 3757 
                 Xenobiotics 
                 Benzoate Metabolism 
                 hippurate 
               
               
                 3771 
                   
                   
                 benzoate 
               
               
                 3978 
                   
                 Food Component/Plant 
                 3-formylindole 
               
               
                 4000 
                   
                   
                 gluconate 
               
               
                 4079 
                   
                   
                 ergothioneine 
               
               
                 4108 
                   
                   
                 homostachydrine* 
               
               
                 4131 
                   
                   
                 mannonate* 
               
               
                 4144 
                   
                   
                 N-glycolylneuraminate 
               
               
                 4221 
                   
                   
                 stachydrine 
               
               
                 4246 
                   
                   
                 methyl glucopyranoside (alpha + beta) 
               
               
                 4274 
                   
                   
                 pyrraline 
               
               
                 4363 
                   
                 Bacterial/Fungal 
                 tartronate (hydroxymalonate) 
               
               
                 4756 
                   
                 Drug - Topical Agents 
                 salicylate 
               
               
                 4832 
                   
                 Chemical 
                 sulfate* 
               
               
                 4835 
                   
                   
                 O-sulfo-L-tyrosine 
               
               
                 4899 
                   
                   
                 ectoine 
               
               
                 4926 
                   
                   
                 phenol red 
               
               
                 4930 
                   
                   
                 perfluorooctanesulfonate (PFOS) 
               
               
                 4971 
                   
                   
                 thioproline 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 4B 
               
               
                   
               
               
                 PSO 
                 Platform 
                 Comp ID 
                 KEGG 
                 HMDB 
                 PUBCHEM 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1 
                 LC/MS pos early 
                 58 
                 C00037 
                 HMDB00123 
                 750 
               
               
                 2 
                 LC/MS pos early 
                 27710 
                   
                 HMDB00532 
                 10972 
               
               
                 5 
                 LC/MS pos early 
                 5086 
                 C01026 
                 HMDB00092 
                 673 
               
               
                 6 
                 LC/MS pos early 
                 3141 
                 C00719 
                 HMDB00043 
                 247 
               
               
                 9 
                 LC/MS pos early 
                 1648 
                 C00065 
                 HMDB00187 
                 5951 
               
               
                 10 
                 LC/MS polar 
                 37076 
                   
                 HMDB02931 
                 65249 
               
               
                 14 
                 LC/MS pos early 
                 543 
                 C01005 
                 HMDB00272 
                 68841 
               
               
                 16 
                 LC/MS pos early 
                 1284 
                 C00188 
                 HMDB00167 
                 6288 
               
               
                 17 
                 LC/MS neg 
                 33939 
                   
                 HMDB62557 
                 152204 
               
               
                 18 
                 LC/MS polar 
                 15142 
                 C05519 
                 HMDB04041 
                 99289 
               
               
                 21 
                 LC/MS polar 
                 18351 
                 C00263 
                 HMDB00719 
                 12647 
               
               
                 28 
                 LC/MS pos early 
                 1126 
                 C00041 
                 HMDB00161 
                 5950 
               
               
                 30 
                 LC/MS polar 
                 1585 
                 C02847 
                 HMDB00766 
                 88064 
               
               
                 34 
                 LC/MS pos early 
                 443 
                 C00049 
                 HMDB00191 
                 5960 
               
               
                 35 
                 LC/MS polar 
                 22185 
                 C01042 
                 HMDB00812 
                 65065 
               
               
                 38 
                 LC/MS pos early 
                 512 
                 C00152 
                 HMDB00168 
                 6267 
               
               
                 39 
                 LC/MS polar 
                 33942 
                   
                 HMDB06028 
                 99715 
               
               
                 40 
                 LC/MS pos early 
                 62060 
                 C03124 
                 HMDB32332 
                 97663 
               
               
                 41 
                 LC/MS pos early 
                 57 
                 C00025 
                 HMDB00148 
                 611 
               
               
                 42 
                 LC/MS pos early 
                 53 
                 C00064 
                 HMDB00641 
                 5961 
               
               
                 43 
                 LC/MS polar 
                 62101 
               
               
                 44 
                 LC/MS polar 
                 15720 
                 C00624 
                 HMDB01138 
                 70914 
               
               
                 45 
                 LC/MS pos early 
                 33943 
                 C02716 
                 HMDB06029 
                 182230 
               
               
                 47 
                 LC/MS pos early 
                 40499 
                 C03079 
                 HMDB01344 
                 439902 
               
               
                 50 
                 LC/MS pos early 
                 33487 
                   
                 HMDB61715 
                 68662 
               
               
                 51 
                 LC/MS pos early 
                 46225 
                   
                   
                 134508 
               
               
                 52 
                 LC/MS pos early 
                 35665 
                 C12270 
                 HMDB01067 
                 5255 
               
               
                 53 
                 LC/MS neg 
                 54923 
                 C20775 
                   
                 7E+07 
               
               
                 54 
                 LC/MS pos early 
                 1416 
                 C00334 
                 HMDB00112 
                 119 
               
               
                 55 
                 LC/MS pos early 
                 40007 
                   
                 HMDB02201 
                 2572 
               
               
                 56 
                 LC/MS pos early 
                 39577 
                 C15987 
                   
                 70703 
               
               
                 59 
                 LC/MS pos early 
                 42370 
                 C04322 
                 HMDB01301 
                 1196 
               
               
                 65 
                 LC/MS pos early 
                 59 
                 C00135 
                 HMDB00177 
                 6274 
               
               
                 66 
                 LC/MS pos early 
                 30460 
                 C01152 
                 HMDB00001 
                 92105 
               
               
                 67 
                 LC/MS pos early 
                 15677 
                 C01152 
                 HMDB00479 
                 64969 
               
               
                 68 
                 LC/MS pos early 
                 33946 
                 C02997 
                 HMDB32055 
                 75619 
               
               
                 74 
                 LC/MS pos early 
                 40730 
                   
                 HMDB02271 
                 70630 
               
               
                 75 
                 LC/MS pos early 
                 43493 
                 C00439 
                 HMDB00854 
                 439233 
               
               
                 76 
                 LC/MS pos early 
                 15716 
                 C05568 
                 HMDB02320 
                 440129 
               
               
                 77 
                 LC/MS pos early 
                 1768 
                 C00386 
                 HMDB00033 
                 439224 
               
               
                 80 
                 LC/MS pos early 
                 15747 
                 C01262 
                 HMDB00194 
                 112072 
               
               
                 82 
                 LC/MS pos early 
                 43831 
                 C05127 
                 HMDB00898 
                 3614 
               
               
                 83 
                 LC/MS pos early 
                 32350 
                 C05828 
                 HMDB02820 
                 75810 
               
               
                 84 
                 LC/MS pos early 
                 61868 
                 C05131 
                 HMDB02331 
                 5E+06 
               
               
                 92 
                 LC/MS pos early 
                 1301 
                 C00047 
                 HMDB00182 
                 5962 
               
               
                 93 
                 LC/MS polar 
                 36751 
                 C12989 
                 HMDB00446 
                 92907 
               
               
                 99 
                 LC/MS pos early 
                 62860 
                 C02728 
                 HMDB02038 
                 164795 
               
               
                 100 
                 LC/MS pos early 
                 62862 
                 C05545 
                 HMDB13287 
                 193344 
               
               
                 101 
                 LC/MS pos early 
                 1498 
                 C03793 
                 HMDB01325 
                 440120 
               
               
                 102 
                 LC/MS pos early 
                 15685 
                 C16741 
                 HMDB00450 
                 1029 
               
               
                 103 
                 LC/MS pos early 
                 43582 
               
               
                 105 
                 LC/MS neg 
                 6146 
                 C00956 
                 HMDB00510 
                 469 
               
               
                 107 
                 LC/MS polar 
                 38347 
                 C00322 
                 HMDB00225 
                 71 
               
               
                 113 
                 LC/MS pos early 
                 1444 
                 C00408 
                 HMDB00070 
                 849 
               
               
                 114 
                 LC/MS polar 
                 43231 
                   
                 HMDB61705 
                 3E+06 
               
               
                 117 
                 LC/MS pos early 
                 18319 
                 C00431 
                 HMDB03355 
                 138 
               
               
                 119 
                 LC/MS pos early 
                 57687 
               
               
                 120 
                 LC/MS pos early 
                 64 
                 C00079 
                 HMDB00159 
                 6140 
               
               
                 121 
                 LC/MS neg 
                 33950 
                 C03519 
                 HMDB00512 
                 74839 
               
               
                 122 
                 LC/MS neg 
                 62566 
               
               
                 126 
                 LC/MS polar 
                 22130 
                 C05607 
                 HMDB00779 
                 3848 
               
               
                 137 
                 LC/MS neg 
                 1299 
                 C00082 
                 HMDB00158 
                 6057 
               
               
                 138 
                 LC/MS neg 
                 32390 
                   
                 HMDB00866 
                 68310 
               
               
                 150 
                 LC/MS neg 
                 32197 
                 C03672 
                 HMDB00755 
                 9378 
               
               
                 154 
                 LC/MS neg 
                 32553 
                 C02180 
                 HMDB60015 
                 74426 
               
               
                 180 
                 LC/MS pos early 
                 43392 
                   
                 HMDB06050 
                 91482 
               
               
                 181 
                 LC/MS pos early 
                 37451 
                   
                 HMDB14903 
                 76957 
               
               
                 191 
                 LC/MS neg 
                 48433 
                   
                   
                 759256 
               
               
                 210 
                 LC/MS pos early 
                 54 
                 C00078 
                 HMDB00929 
                 6305 
               
               
                 217 
                 LC/MS pos early 
                 48782 
                   
                   
                 1E+07 
               
               
                 221 
                 LC/MS pos early 
                 15140 
                 C00328 
                 HMDB00684 
                 161166 
               
               
                 227 
                 LC/MS polar 
                 43549 
                 C05653 
                 HMDB04089 
                 101399 
               
               
                 241 
                 LC/MS neg 
                 18349 
                 C02043 
                 HMDB00671 
                 92904 
               
               
                 254 
                 LC/MS neg 
                 27672 
                   
                 HMDB00682 
                 10258 
               
               
                 261 
                 LC/MS pos early 
                 60 
                 C00123 
                 HMDB00687 
                 6106 
               
               
                 263 
                 LC/MS neg 
                 62559 
               
               
                 265 
                 LC/MS neg 
                 22116 
                 C00233 
                 HMDB00695 
                 70 
               
               
                 273 
                 LC/MS pos early 
                 34407 
                   
                 HMDB00688 
                 6E+06 
               
               
                 280 
                 LC/MS polar 
                 12129 
                   
                 HMDB00754 
                 69362 
               
               
                 296 
                 LC/MS pos early 
                 1125 
                 C00407 
                 HMDB00172 
                 6306 
               
               
                 299 
                 LC/MS neg 
                 62558 
               
               
                 300 
                 LC/MS neg 
                 15676 
                 C00671 
                 HMDB03736 
                 47 
               
               
                 301 
                 LC/MS polar 
                 46537 
                   
                 HMDB00407 
                 99823 
               
               
                 303 
                 LC/MS pos early 
                 45095 
                   
                 HMDB00378 
                 6E+06 
               
               
                 306 
                 LC/MS pos early 
                 35428 
                   
                 HMDB02366 
                 2E+07 
               
               
                 311 
                 LC/MS polar 
                 15765 
                   
                 HMDB00622 
                 11756 
               
               
                 312 
                 LC/MS polar 
                 15745 
                   
                 HMDB01844 
                 10349 
               
               
                 318 
                 LC/MS pos early 
                 1649 
                 C00183 
                 HMDB00883 
                 6287 
               
               
                 321 
                 LC/MS neg 
                 62562 
               
               
                 323 
                 LC/MS polar 
                 44526 
                 C00141 
                 HMDB00019 
                 49 
               
               
                 326 
                 LC/MS pos early 
                 33441 
                   
                 HMDB00736 
                 168379 
               
               
                 328 
                 LC/MS polar 
                 1549 
                 C06001 
                 HMDB00336 
                 87 
               
               
                 332 
                 LC/MS pos early 
                 1302 
                 C00073 
                 HMDB00696 
                 6137 
               
               
                 333 
                 LC/MS neg 
                 1589 
                 C02712 
                 HMDB11745 
                 448580 
               
               
                 334 
                 LC/MS neg 
                 2829 
                 C03145 
                 HMDB01015 
                 439750 
               
               
                 337 
                 LC/MS pos early 
                 18374 
                 C02989 
                 HMDB02005 
                 158980 
               
               
                 342 
                 LC/MS pos early 
                 15915 
                 C00019 
                 HMDB01185 
                 34756 
               
               
                 343 
                 LC/MS neg 
                 42382 
                 C00021 
                 HMDB00939 
                 439155 
               
               
                 349 
                 LC/MS pos early 
                 15705 
                 C02291 
                 HMDB00099 
                 439258 
               
               
                 351 
                 LC/MS pos early 
                 1868 
                 C00097 
                 HMDB00574 
                 5862 
               
               
                 353 
                 LC/MS pos early 
                 39592 
                   
                 HMDB02108 
                 24417 
               
               
                 362 
                 LC/MS pos early 
                 37443 
                 C00606 
                 HMDB00996 
                 109 
               
               
                 363 
                 LC/MS pos early 
                 590 
                 C00519 
                 HMDB00965 
                 107812 
               
               
                 364 
                 LC/MS neg 
                 2125 
                 C00245 
                 HMDB00251 
                 1123 
               
               
                 365 
                 LC/MS neg 
                 48187 
                   
                   
                 159864 
               
               
                 367 
                 LC/MS neg 
                 35117 
                 C01959 
                 HMDB03584 
                 68340 
               
               
                 369 
                 LC/MS polar 
                 47089 
                 C00506 
                 HMDB02757 
                 72886 
               
               
                 371 
                 LC/MS pos early 
                 1638 
                 C00062 
                 HMDB00517 
                 232 
               
               
                 372 
                 LC/MS pos early 
                 15497 
                 C03406 
                 HMDB00052 
                 828 
               
               
                 373 
                 LC/MS pos early 
                 1670 
                 C00086 
                 HMDB00294 
                 1176 
               
               
                 375 
                 LC/MS pos early 
                 1493 
                 C00077 
                 HMDB03374 
                 6262 
               
               
                 379 
                 LC/MS pos early 
                 55072 
                 C03771 
                 HMDB04225 
                 558 
               
               
                 380 
                 LC/MS pos early 
                 2132 
                 C00327 
                 HMDB00904 
                 9750 
               
               
                 381 
                 LC/MS pos early 
                 22137 
                 C01924 
                 HMDB00670 
                 9085 
               
               
                 382 
                 LC/MS polar 
                 22138 
                 C02427 
                 HMDB00679 
                 65072 
               
               
                 383 
                 LC/MS neg 
                 1898 
                 C00148 
                 HMDB00162 
                 145742 
               
               
                 386 
                 LC/MS pos early 
                 36808 
                 C03626 
                 HMDB01539 
                 123831 
               
               
                 387 
                 LC/MS pos early 
                 33953 
                 C02562 
                 HMDB04620 
                 67427 
               
               
                 392 
                 LC/MS neg 
                 43249 
                   
                   
                 1E+07 
               
               
                 397 
                 LC/MS pos early 
                 32306 
                 C01157 
                 HMDB00725 
                 5810 
               
               
                 399 
                 LC/MS pos early 
                 35127 
                   
                 HMDB06695 
                 1E+07 
               
               
                 405 
                 LC/MS pos early 
                 57461 
                   
                 HMDB03148 
                 160437 
               
               
                 410 
                 LC/MS pos early 
                 43802 
                 C00581 
                 HMDB00128 
                 763 
               
               
                 411 
                 LC/MS pos early 
                 27718 
                 C00300 
                 HMDB00064 
                 586 
               
               
                 412 
                 LC/MS pos early 
                 513 
                 C00791 
                 HMDB00562 
                 588 
               
               
                 418 
                 LC/MS pos early 
                 1408 
                 C00134 
                 HMDB01414 
                 1045 
               
               
                 421 
                 LC/MS pos early 
                 485 
                 C00315 
                 HMDB01257 
                 1102 
               
               
                 426 
                 LC/MS pos early 
                 603 
                 C00750 
                 HMDB01256 
                 1103 
               
               
                 429 
                 LC/MS pos early 
                 1419 
                 C00170 
                 HMDB01173 
                 439176 
               
               
                 430 
                 LC/MS pos early 
                 37496 
                 C02714 
                 HMDB02064 
                 122356 
               
               
                 436 
                 LC/MS pos early 
                 57814 
               
               
                 438 
                 LC/MS pos early 
                 48114 
                 C02294 
                 HMDB01522 
                 10111 
               
               
                 439 
                 LC/MS pos early 
                 15681 
                 C01035 
                 HMDB03464 
                 500 
               
               
                 442 
                 LC/MS pos early 
                 2127 
                 C00051 
                 HMDB00125 
                 124886 
               
               
                 443 
                 LC/MS pos early 
                 27727 
                 C00127 
                 HMDB03337 
                 65359 
               
               
                 445 
                 LC/MS pos early 
                 35159 
                   
                 HMDB00656 
                 4E+06 
               
               
                 446 
                 LC/MS pos early 
                 33944 
                 C11347 
                   
                 4E+06 
               
               
                 447 
                 LC/MS pos early 
                 15731 
                 C03451 
                 HMDB01066 
                 440018 
               
               
                 451 
                 LC/MS neg 
                 1494 
                 C01879 
                 HMDB00267 
                 7405 
               
               
                 454 
                 LC/MS polar 
                 52281 
               
               
                 456 
                 LC/MS pos early 
                 34592 
                   
                 HMDB05765 
                 7E+06 
               
               
                 459 
                 LC/MS neg 
                 48487 
               
               
                 460 
                 LC/MS neg 
                 62807 
               
               
                 461 
                 LC/MS neg 
                 62804 
                 C00920 
                   
                 1E+07 
               
               
                 465 
                 LC/MS pos early 
                 37063 
                   
                 HMDB29142 
                 440103 
               
               
                 467 
                 LC/MS pos early 
                 36738 
                 C05282 
                 HMDB11737 
                 92865 
               
               
                 468 
                 LC/MS pos early 
                 2730 
                 C05283 
                 HMDB11738 
                 150914 
               
               
                 469 
                 LC/MS pos early 
                 33949 
                   
                 HMDB11667 
                 165527 
               
               
                 471 
                 LC/MS pos early 
                 34456 
                   
                 HMDB11170 
                 1E+07 
               
               
                 472 
                 LC/MS neg 
                 18369 
                   
                 HMDB11171 
                 151023 
               
               
                 473 
                 LC/MS pos early 
                 55015 
                   
                   
                 65254 
               
               
                 474 
                 LC/MS pos early 
                 33934 
                   
                 HMDB03869 
                 7E+06 
               
               
                 475 
                 LC/MS pos early 
                 44872 
                   
                 HMDB29155 
                 7E+06 
               
               
                 476 
                 LC/MS neg 
                 33422 
                   
                 HMDB00594 
                 111299 
               
               
                 477 
                 LC/MS pos early 
                 33364 
                   
                 HMDB29159 
                 8E+07 
               
               
                 478 
                 LC/MS pos early 
                 33947 
                   
                 HMDB29160 
                 4E+06 
               
               
                 479 
                 LC/MS pos early 
                 2734 
                   
                 HMDB11741 
                 94340 
               
               
                 480 
                 LC/MS pos early 
                 43829 
                   
                 HMDB11172 
                 7E+06 
               
               
                 756 
                 LC/MS pos early 
                 40703 
                   
                 HMDB11178 
                 6E+06 
               
               
                 929 
                 LC/MS neg 
                 33945 
                 C05598 
                 HMDB00821 
                 68144 
               
               
                 955 
                 LC/MS neg 
                 20675 
                 C07326 
                 HMDB02712 
                 64960 
               
               
                 958 
                 LC/MS polar 
                 20488 
                 C00031 
                 HMDB00122 
                 79025 
               
               
                 959 
                 LC/MS polar 
                 31260 
                 C00668 
                 HMDB01401 
                 5958 
               
               
                 965 
                 LC/MS neg 
                 46896 
                 C00354 
               
               
                 967 
                 LC/MS neg 
                 15522 
                 C00111 
                 HMDB01473 
                 668 
               
               
                 972 
                 LC/MS neg 
                 1414 
                 C00597 
                 HMDB00807 
                 724 
               
               
                 973 
                 LC/MS neg 
                 597 
                 C00074 
                 HMDB00263 
                 1005 
               
               
                 974 
                 LC/MS polar 
                 22250 
                 C00022 
                 HMDB00243 
                 1060 
               
               
                 975 
                 LC/MS polar 
                 527 
                 C00186 
                 HMDB00190 
                 612 
               
               
                 978 
                 LC/MS polar 
                 1572 
                 C00258 
                 HMDB00139 
                 752 
               
               
                 981 
                 LC/MS neg 
                 15442 
                 C00345 
                 HMDB01316 
                 91493 
               
               
                 982 
                 LC/MS polar 
                 1474 
                 C00199 
                 HMDB00618 
                 439184 
               
               
                 983 
                 LC/MS polar 
                 561 
                 C00117 
                 HMDB01548 
               
               
                 984 
                 LC/MS polar 
                 1763 
                 C00620 
                 HMDB01489 
                 439236 
               
               
                 986 
                 LC/MS pos early 
                 35649 
                 C05382 
                 HMDB01068 
                 616 
               
               
                 993 
                 LC/MS polar 
                 1471 
                 C00121 
                 HMDB00283 
                 5779 
               
               
                 994 
                 LC/MS polar 
                 15772 
                 C00474 
                 HMDB00508 
                 6912 
               
               
                 995 
                 LC/MS polar 
                 27731 
                 C01685 
                 HMDB00867 
                 5E+06 
               
               
                 997 
                 LC/MS polar 
                 37285 
                 C00231 
                 HMDB00868 
                 439190 
               
               
                 1018 
                 LC/MS polar 
                 48885 
                 C01904 
                   
                 6912 
               
               
                 1020 
                 LC/MS polar 
                 48255 
               
               
                 1023 
                 LC/MS polar 
                 53237 
                   
                 HMDB03219 
                 5E+06 
               
               
                 1024 
                 LC/MS polar 
                 61858 
               
               
                 1028 
                 LC/MS neg 
                 15910 
                 C02052 
                 HMDB01296 
                 446495 
               
               
                 1030 
                 LC/MS neg 
                 44688 
                 C01835 
                 HMDB01262 
                 439586 
               
               
                 1033 
                 LC/MS polar 
                 15586 
                 C00208 
                 HMDB00163 
                 1E+07 
               
               
                 1073 
                 LC/MS polar 
                 577 
                 C00095 
                 HMDB00660 
                 5984 
               
               
                 1078 
                 LC/MS polar 
                 46142 
                 C00794 
                 HMDB00247 
                 5780 
               
               
                 1079 
                 LC/MS polar 
                 584 
                 C00159 
                 HMDB00169 
                 18950 
               
               
                 1080 
                 LC/MS polar 
                 1469 
                 C00275 
                 HMDB01078 
                 439198 
               
               
                 1090 
                 LC/MS polar 
                 15706 
                 C00446 
                 HMDB00645 
                 123912 
               
               
                 1099 
                 LC/MS polar 
                 27719 
                 C00880 
                 HMDB00565 
                 128869 
               
               
                 1104 
                 LC/MS polar 
                 32344 
                 C00029 
                 HMDB00286 
                 8629 
               
               
                 1108 
                 LC/MS polar 
                 15860 
                 C00052 
                 HMDB00302 
                 18068 
               
               
                 1109 
                 LC/MS neg 
                 2763 
                 C00167 
                 HMDB00935 
                 17473 
               
               
                 1111 
                 LC/MS polar 
                 15903 
               
               
                 1115 
                 LC/MS neg 
                 46148 
               
               
                 1116 
                 LC/MS polar 
                 36831 
                 C00128 
                 HMDB01176 
                 448209 
               
               
                 1123 
                 LC/MS polar 
                 580 
                 C00352 
                 HMDB01254 
                 439217 
               
               
                 1127 
                 LC/MS polar 
                 15443 
                 C00191 
                 HMDB00127 
                 444791 
               
               
                 1131 
                 LC/MS polar 
                 15107 
                 C00357 
                 HMDB02817 
                 439219 
               
               
                 1132 
                 LC/MS polar 
                 15741 
                 C04256 
                 HMDB01367 
                 440364 
               
               
                 1138 
                 LC/MS pos early 
                 32377 
                 C00270 
                 HMDB00230 
                 439197 
               
               
                 1149 
                 LC/MS pos early 
                 48149 
                 C04540 
                 HMDB00489 
                 123826 
               
               
                 1150 
                 LC/MS polar 
                 42420 
                   
                 HMDB00613 
                 3E+06 
               
               
                 1152 
                 LC/MS pos early 
                 46539 
                   
                 HMDB00215 
                 24139 
               
               
                 1157 
                 LC/MS neg 
                 1564 
                 C00158 
                 HMDB00094 
                 311 
               
               
                 1163 
                 LC/MS polar 
                 528 
                 C00026 
                 HMDB00208 
                 51 
               
               
                 1165 
                 LC/MS pos early 
                 37058 
                   
                 HMDB61717 
                 7E+07 
               
               
                 1166 
                 LC/MS polar 
                 1437 
                 C00042 
                 HMDB00254 
                 1110 
               
               
                 1167 
                 LC/MS polar 
                 1643 
                 C00122 
                 HMDB00134 
                 444972 
               
               
                 1169 
                 LC/MS neg 
                 1303 
                 C00149 
                 HMDB00156 
                 525 
               
               
                 1179 
                 LC/MS neg 
                 52282 
               
               
                 1181 
                 LC/MS polar 
                 15488 
                 C00227 
                 HMDB01494 
                 186 
               
               
                 1183 
                 LC/MS neg 
                 42109 
                 C00009 
                 HMDB01429 
                 1061 
               
               
                 1201 
                 LC/MS neg 
                 32489 
                 C01585 
                 HMDB00535 
                 8892 
               
               
                 1203 
                 LC/MS neg 
                 32492 
                 C06423 
                 HMDB00482 
                 379 
               
               
                 1204 
                 LC/MS neg 
                 12035 
                 C01601 
                 HMDB00847 
                 8158 
               
               
                 1205 
                 LC/MS neg 
                 1642 
                 C01571 
                 HMDB00511 
                 2969 
               
               
                 1217 
                 LC/MS neg 
                 1336 
                 C00249 
                 HMDB00220 
                 985 
               
               
                 1218 
                 LC/MS neg 
                 33447 
                 C08362 
                 HMDB03229 
                 445638 
               
               
                 1223 
                 LC/MS neg 
                 1358 
                 C01530 
                 HMDB00827 
                 5281 
               
               
                 1225 
                 LC/MS neg 
                 52285 
               
               
                 1236 
                 LC/MS neg 
                 1118 
                 C06425 
                 HMDB02212 
                 10467 
               
               
                 1239 
                 LC/MS neg 
                 33587 
                 C16526 
                 HMDB02231 
                 5E+06 
               
               
                 1244 
                 LC/MS neg 
                 1552 
                 C08316 
                 HMDB02068 
                 5E+06 
               
               
                 1247 
                 LC/MS neg 
                 52674 
                 C08323 
                 HMDB02368 
                 5E+06 
               
               
                 1253 
                 LC/MS neg 
                 57652 
                   
                 HMDB00477 
               
               
                 1258 
                 LC/MS neg 
                 18467 
                 C06428 
                 HMDB01999 
                 446284 
               
               
                 1259 
                 LC/MS neg 
                 32504 
                 C16513 
                 HMDB06528 
                 6E+06 
               
               
                 1260 
                 LC/MS neg 
                 44675 
                 C06429 
                 HMDB02183 
                 445580 
               
               
                 1264 
                 LC/MS neg 
                 57810 
                   
                 HMDB02007 
                 1E+07 
               
               
                 1265 
                 LC/MS neg 
                 1105 
                 C01595 
                 HMDB00673 
                 5E+06 
               
               
                 1267 
                 LC/MS neg 
                 34035 
                 C06426 
                 HMDB03073 
                 5E+06 
               
               
                 1269 
                 LC/MS neg 
                 35718 
                 C03242 
                 HMDB02925 
                 5E+06 
               
               
                 1270 
                 LC/MS neg 
                 1110 
                 C00219 
                 HMDB01043 
                 444899 
               
               
                 1271 
                 LC/MS neg 
                 32980 
                 C16527 
                 HMDB02226 
                 5E+06 
               
               
                 1272 
                 LC/MS neg 
                 37478 
                 C16513 
                 HMDB01976 
                 6E+06 
               
               
                 1273 
                 LC/MS neg 
                 32415 
                 C16533 
                 HMDB61714 
                 5E+06 
               
               
                 1274 
                 LC/MS neg 
                 17805 
                 C16525 
                 HMDB05060 
                 6E+06 
               
               
                 1276 
                 LC/MS neg 
                 35174 
                   
                 HMDB10378 
                 5E+06 
               
               
                 1277 
                 LC/MS neg 
                 57467 
               
               
                 1351 
                 LC/MS polar 
                 396 
                 C00489 
                 HMDB00661 
                 743 
               
               
                 1355 
                 LC/MS polar 
                 37253 
                 C02630 
                 HMDB00606 
                 43 
               
               
                 1359 
                 LC/MS polar 
                 31934 
                 C02360 
                 HMDB00321 
                 193530 
               
               
                 1360 
                 LC/MS polar 
                 62069 
                   
                 HMDB00345 
                 151913 
               
               
                 1363 
                 LC/MS polar 
                 20676 
                 C01384 
                 HMDB00176 
                 444266 
               
               
                 1372 
                 LC/MS polar 
                 32398 
                 C08277 
                 HMDB00792 
                 5192 
               
               
                 1430 
                 LC/MS pos early 
                 43761 
                   
                   
                 227939 
               
               
                 1446 
                 LC/MS pos early 
                 32412 
                 C02862 
                 HMDB02013 
                 439829 
               
               
                 1449 
                 LC/MS pos early 
                 32452 
                 C03017 
                 HMDB00824 
                 107738 
               
               
                 1452 
                 LC/MS polar 
                 1496 
                 C02170 
                 HMDB00202 
                 487 
               
               
                 1480 
                 LC/MS pos early 
                 32198 
                 C02571 
                 HMDB00201 
                 1 
               
               
                 1482 
                 LC/MS pos early 
                 43264 
                   
                 HMDB13127 
                 5E+07 
               
               
                 1483 
                 LC/MS pos early 
                 52984 
                   
                 HMDB13127 
               
               
                 1485 
                 LC/MS pos late 
                 32328 
                   
                 HMDB00705 
                 6E+06 
               
               
                 1487 
                 LC/MS pos early 
                 62557 
               
               
                 1488 
                 LC/MS pos late 
                 33936 
                 C02838 
                 HMDB00791 
                 123701 
               
               
                 1495 
                 LC/MS pos late 
                 34534 
                   
                 HMDB02250 
                 1E+07 
               
               
                 1496 
                 LC/MS pos late 
                 33952 
                   
                 HMDB05066 
                 6E+06 
               
               
                 1498 
                 LC/MS pos late 
                 44681 
                 C02990 
                 HMDB00222 
                 461 
               
               
                 1499 
                 LC/MS pos late 
                 53223 
                   
                   
                 7E+07 
               
               
                 1500 
                 LC/MS pos late 
                 34409 
                   
                 HMDB00848 
                 6E+06 
               
               
                 1501 
                 LC/MS pos late 
                 46223 
                   
                 HMDB06469 
                 6E+06 
               
               
                 1503 
                 LC/MS pos late 
                 61840 
               
               
                 1504 
                 LC/MS pos late 
                 35160 
                   
                 HMDB05065 
                 6E+06 
               
               
                 1506 
                 LC/MS pos late 
                 48182 
                   
                   
                 9E+07 
               
               
                 1517 
                 LC/MS pos late 
                 57513 
                   
                 HMDB06460 
               
               
                 1518 
                 LC/MS pos late 
                 57518 
               
               
                 1519 
                 LC/MS pos late 
                 57528 
               
               
                 1521 
                 LC/MS pos late 
                 62436 
               
               
                 1522 
                 LC/MS pos late 
                 57521 
               
               
                 1523 
                 LC/MS pos late 
                 57520 
               
               
                 1524 
                 LC/MS pos late 
                 57519 
               
               
                 1527 
                 LC/MS pos late 
                 57527 
               
               
                 1528 
                 LC/MS pos late 
                 57529 
               
               
                 1529 
                 LC/MS pos late 
                 57523 
               
               
                 1536 
                 LC/MS pos late 
                 57522 
               
               
                 1537 
                 LC/MS pos late 
                 57530 
               
               
                 1539 
                 LC/MS pos late 
                 61839 
               
               
                 1541 
                 LC/MS pos early 
                 36747 
                 C01181 
                 HMDB01161 
                 134 
               
               
                 1542 
                 LC/MS pos early 
                 15500 
                 C00318 
                 HMDB00062 
                 10917 
               
               
                 1547 
                 LC/MS polar 
                 542 
                 C01089 
                 HMDB00357 
                 441 
               
               
                 1565 
                 LC/MS polar 
                 61827 
                   
                   
                 3E+06 
               
               
                 1567 
                 LC/MS neg 
                 42489 
                   
                   
                 21488 
               
               
                 1582 
                 LC/MS neg 
                 22053 
                   
                 HMDB02203 
                 26612 
               
               
                 1711 
                 LC/MS neg 
                 57393 
                 C20388 
                 HMDB12535 
                 5E+06 
               
               
                 1718 
                 LC/MS pos late 
                 38102 
                   
                 HMDB02088 
                 5E+06 
               
               
                 1721 
                 LC/MS pos late 
                 38165 
                 C16512 
                 HMDB02100 
                 4671 
               
               
                 1731 
                 LC/MS neg 
                 39730 
                   
                   
                 168274 
               
               
                 1732 
                 LC/MS neg 
                 39835 
               
               
                 1744 
                 LC/MS pos late 
                 57541 
                   
                 HMDB13648 
                 1E+07 
               
               
                 1753 
                 LC/MS polar 
                 1124 
                 C00137 
                 HMDB00211 
                 892 
               
               
                 1754 
                 LC/MS polar 
                 37112 
                 C19891 
                 HMDB34220 
               
               
                 1782 
                 LC/MS pos early 
                 15506 
                 C00114 
                 HMDB00097 
                 305 
               
               
                 1783 
                 LC/MS pos early 
                 34396 
                 C00588 
                 HMDB01565 
                 1014 
               
               
                 1784 
                 LC/MS polar 
                 34418 
                 C00307 
                 HMDB01413 
                 13804 
               
               
                 1786 
                 LC/MS pos early 
                 15990 
                 C00670 
                 HMDB00086 
                 71920 
               
               
                 1788 
                 LC/MS pos early 
                 1600 
                 C00346 
                 HMDB00224 
                 1015 
               
               
                 1789 
                 LC/MS neg 
                 34410 
                 C00570 
                 HMDB01564 
                 123727 
               
               
                 1790 
                 LC/MS pos early 
                 37455 
                 C01233 
                 HMDB00114 
                 123874 
               
               
                 1791 
                 LC/MS pos early 
                 57404 
                   
                   
                 3E+06 
               
               
                 1792 
                 LC/MS pos early 
                 52307 
                   
                   
                 167572 
               
               
                 1793 
                 LC/MS pos early 
                 40406 
                 C01104 
                 HMDB00925 
                 1145 
               
               
                 1811 
                 LC/MS pos late 
                 19258 
                   
                 HMDB07869 
                 129657 
               
               
                 1815 
                 LC/MS pos late 
                 53195 
                   
                 HMDB07883 
               
               
                 1827 
                 LC/MS pos late 
                 19130 
                   
                 HMDB00564 
                 452110 
               
               
                 1828 
                 LC/MS pos late 
                 52470 
                   
                 HMDB07969 
               
               
                 1829 
                 LC/MS pos late 
                 52616 
                   
                 HMDB07970 
               
               
                 1831 
                 LC/MS pos late 
                 52461 
                   
                 HMDB07972 
                 6E+06 
               
               
                 1834 
                 LC/MS pos late 
                 42446 
                   
                 HMDB07973 
                 5E+06 
               
               
                 1837 
                 LC/MS pos late 
                 54812 
                   
                 HMDB07974 
               
               
                 1841 
                 LC/MS pos late 
                 52454 
               
               
                 1845 
                 LC/MS pos late 
                 52462 
                   
                 HMDB07982 
                 1E+07 
               
               
                 1851 
                 LC/MS pos late 
                 52610 
                   
                 HMDB07991 
                 6E+06 
               
               
                 1866 
                 LC/MS pos late 
                 19132 
                   
                 HMDB08036 
                 94190 
               
               
                 1867 
                 LC/MS pos late 
                 52438 
                   
                 HMDB08038 
               
               
                 1870 
                 LC/MS pos late 
                 52452 
                   
                 HMDB08039 
               
               
                 1878 
                 LC/MS pos late 
                 42450 
                   
                 HMDB08048 
                 2E+07 
               
               
                 1884 
                 LC/MS pos late 
                 52611 
                   
                 HMDB08057 
               
               
                 1889 
                 LC/MS pos late 
                 52457 
                   
                   
                 1E+07 
               
               
                 1892 
                 LC/MS pos late 
                 52453 
               
               
                 1902 
                 LC/MS pos late 
                 52697 
                   
                 HMDB08123 
               
               
                 1903 
                 LC/MS pos late 
                 52603 
                   
                 HMDB08138 
                 5E+06 
               
               
                 1907 
                 LC/MS pos late 
                 52710 
                   
                 HMDB08147 
               
               
                 1945 
                 LC/MS pos late 
                 57341 
                   
                 HMDB08923 
                 445468 
               
               
                 1948 
                 LC/MS pos late 
                 57388 
                   
                 HMDB08925 
                 5E+06 
               
               
                 1949 
                 LC/MS pos late 
                 19263 
                   
                 HMDB05320 
                 5E+06 
               
               
                 1950 
                 LC/MS pos late 
                 42449 
                   
                 HMDB05322 
                 1E+07 
               
               
                 1953 
                 LC/MS pos late 
                 52464 
                   
                 HMDB05323 
                 1E+07 
               
               
                 1955 
                 LC/MS pos late 
                 52465 
                   
                 HMDB05324 
                 1E+07 
               
               
                 1962 
                 LC/MS pos late 
                 42448 
                   
                 HMDB08993 
               
               
                 1970 
                 LC/MS pos late 
                 52447 
                   
                 HMDB09003 
                 5E+06 
               
               
                 1974 
                 LC/MS pos late 
                 52466 
                   
                 HMDB05334 
                 1E+07 
               
               
                 1975 
                 LC/MS pos late 
                 52609 
                   
                   
                 1E+07 
               
               
                 1976 
                 LC/MS pos late 
                 52687 
                   
                 HMDB05349 
                 1E+07 
               
               
                 1979 
                 LC/MS pos late 
                 55041 
                   
                 HMDB09069 
               
               
                 1982 
                 LC/MS pos late 
                 53209 
               
               
                 1985 
                 LC/MS pos late 
                 53189 
                   
                 HMDB09102 
               
               
                 2016 
                 LC/MS pos late 
                 19261 
                 C13880 
                 HMDB12357 
                 5E+06 
               
               
                 2021 
                 LC/MS pos late 
                 19265 
                   
                 HMDB10163 
                 1E+07 
               
               
                 2024 
                 LC/MS pos late 
                 52235 
                   
                 HMDB12383 
               
               
                 2034 
                 LC/MS pos late 
                 52448 
                   
                   
                 5E+06 
               
               
                 2052 
                 LC/MS pos late 
                 52467 
                   
                 HMDB09789 
               
               
                 2067 
                 LC/MS pos late 
                 52449 
                   
                 HMDB09815 
               
               
                 2072 
                 LC/MS pos late 
                 54994 
                   
                 HMDB09844 
               
               
                 2105 
                 LC/MS pos late 
                 33955 
                   
                 HMDB10382 
                 86554 
               
               
                 2106 
                 LC/MS pos late 
                 35253 
                   
                 HMDB61702 
                 2E+07 
               
               
                 2107 
                 LC/MS pos late 
                 33230 
                   
                 HMDB10383 
                 2E+07 
               
               
                 2113 
                 LC/MS pos late 
                 33961 
                   
                 HMDB10384 
                 497299 
               
               
                 2115 
                 LC/MS pos late 
                 48258 
                   
                 HMDB02815 
                 2E+07 
               
               
                 2118 
                 LC/MS pos late 
                 34419 
                 C04100 
                 HMDB10386 
                 1E+07 
               
               
                 2136 
                 LC/MS neg 
                 34061 
                 C05208 
                 HMDB10395 
               
               
                 2157 
                 LC/MS pos late 
                 35631 
                   
                 HMDB11503 
                 1E+07 
               
               
                 2164 
                 LC/MS pos late 
                 42398 
                   
                 HMDB11130 
                 1E+07 
               
               
                 2165 
                 LC/MS neg 
                 41220 
                   
                 HMDB11129 
               
               
                 2166 
                 LC/MS pos late 
                 35628 
                   
                 HMDB11506 
                 1E+07 
               
               
                 2168 
                 LC/MS pos late 
                 36600 
                   
                 HMDB11507 
                 5E+07 
               
               
                 2179 
                 LC/MS neg 
                 35186 
                   
                 HMDB11517 
                 4E+07 
               
               
                 2192 
                 LC/MS neg 
                 46130 
                   
                   
                 1E+07 
               
               
                 2193 
                 LC/MS neg 
                 45966 
                   
                   
                 1E+07 
               
               
                 2194 
                 LC/MS neg 
                 19260 
                   
                 HMDB61694 
                 1E+07 
               
               
                 2199 
                 LC/MS neg 
                 45970 
                   
                   
                 3E+06 
               
               
                 2203 
                 LC/MS neg 
                 45968 
               
               
                 2206 
                 LC/MS neg 
                 35305 
                   
                 HMDB61695 
               
               
                 2209 
                 LC/MS neg 
                 19324 
                   
                 HMDB61696 
               
               
                 2211 
                 LC/MS neg 
                 36602 
               
               
                 2217 
                 LC/MS neg 
                 34214 
                   
                 HMDB61690 
               
               
                 2310 
                 LC/MS pos late 
                 52477 
                   
                 HMDB11342 
               
               
                 2311 
                 LC/MS pos late 
                 52677 
                   
                 HMDB11343 
               
               
                 2312 
                 LC/MS pos late 
                 52716 
                   
                 HMDB11206 
                 1E+07 
               
               
                 2313 
                 LC/MS pos late 
                 52713 
                   
                 HMDB11207 
               
               
                 2314 
                 LC/MS pos late 
                 52673 
                   
                 HMDB11352 
               
               
                 2318 
                 LC/MS pos late 
                 52614 
                   
                 HMDB11375 
               
               
                 2327 
                 LC/MS pos late 
                 52475 
                   
                 HMDB05779 
                 1E+07 
               
               
                 2343 
                 LC/MS pos late 
                 39270 
               
               
                 2345 
                 LC/MS pos late 
                 44621 
               
               
                 2347 
                 LC/MS pos late 
                 39271 
               
               
                 2348 
                 LC/MS pos late 
                 54691 
                   
                 HMDB11441 
               
               
                 2350 
                 LC/MS neg 
                 15122 
                 C00116 
                 HMDB00131 
                 753 
               
               
                 2351 
                 LC/MS pos early 
                 43847 
                 C00093 
                 HMDB00126 
                 754 
               
               
                 2356 
                 LC/MS polar 
                 48857 
                 C03274 
                   
                 439964 
               
               
                 2357 
                 LC/MS neg 
                 35625 
                 C01885 
                 HMDB11561 
                 79050 
               
               
                 2360 
                 LC/MS neg 
                 21127 
                   
                 HMDB31074 
                 14900 
               
               
                 2361 
                 LC/MS neg 
                 52431 
                   
                 HMDB11565 
               
               
                 2364 
                 LC/MS neg 
                 21184 
                   
                 HMDB11567 
                 5E+06 
               
               
                 2371 
                 LC/MS neg 
                 34397 
                 C13857 
                 HMDB11549 
                 5E+06 
               
               
                 2374 
                 LC/MS neg 
                 35153 
                   
                 HMDB11587 
               
               
                 2375 
                 LC/MS neg 
                 34383 
                   
                 HMDB11530 
                 137938 
               
               
                 2376 
                 LC/MS neg 
                 33419 
                   
                 HMDB11533 
                 123409 
               
               
                 2379 
                 LC/MS neg 
                 21232 
                   
                 HMDB11537 
                 5E+06 
               
               
                 2381 
                 LC/MS neg 
                 19266 
                 C13856 
                 HMDB04666 
                 5E+06 
               
               
                 2383 
                 LC/MS neg 
                 48675 
                   
                 HMDB11557 
               
               
                 2394 
                 LC/MS pos late 
                 54954 
               
               
                 2395 
                 LC/MS pos late 
                 54966 
               
               
                 2407 
                 LC/MS pos late 
                 54990 
                   
                 HMDB07098 
               
               
                 2411 
                 LC/MS pos late 
                 54942 
                 C13861 
                 HMDB07102 
               
               
                 2413 
                 LC/MS pos late 
                 52634 
                   
                 HMDB07103 
               
               
                 2416 
                 LC/MS pos late 
                 52631 
               
               
                 2418 
                 LC/MS pos late 
                 54941 
               
               
                 2419 
                 LC/MS pos late 
                 54957 
                   
                 HMDB07112 
               
               
                 2420 
                 LC/MS pos late 
                 54958 
                   
                 HMDB07112 
               
               
                 2422 
                 LC/MS pos late 
                 57373 
                   
                 HMDB07121 
               
               
                 2423 
                 LC/MS pos late 
                 57374 
                   
                 HMDB07121 
               
               
                 2426 
                 LC/MS pos late 
                 54947 
               
               
                 2429 
                 LC/MS pos late 
                 54946 
                   
                 HMDB07218 
               
               
                 2431 
                 LC/MS pos late 
                 46798 
                   
                 HMDB07219 
               
               
                 2432 
                 LC/MS pos late 
                 46799 
                   
                 HMDB07219 
               
               
                 2442 
                 LC/MS pos late 
                 57450 
               
               
                 2443 
                 LC/MS pos late 
                 57449 
               
               
                 2445 
                 LC/MS pos late 
                 54961 
                   
                 HMDB07228 
               
               
                 2448 
                 LC/MS pos late 
                 57387 
               
               
                 2449 
                 LC/MS pos late 
                 57368 
               
               
                 2474 
                 LC/MS pos late 
                 17769 
                 C00836 
                 HMDB00269 
                 3126 
               
               
                 2480 
                 LC/MS pos late 
                 52604 
                   
                 HMDB11760 
                 5E+06 
               
               
                 2481 
                 LC/MS pos late 
                 1759 
                   
                   
                 5E+06 
               
               
                 2488 
                 LC/MS pos late 
                 44877 
                   
                 HMDB04949 
                 5E+06 
               
               
                 2491 
                 LC/MS pos late 
                 54979 
                   
                 HMDB04950 
                 5E+06 
               
               
                 2493 
                 LC/MS pos late 
                 57424 
                   
                 HMDB04951 
                 5E+06 
               
               
                 2498 
                 LC/MS pos late 
                 57417 
               
               
                 2499 
                 LC/MS pos late 
                 57372 
               
               
                 2513 
                 LC/MS pos late 
                 57432 
               
               
                 2514 
                 LC/MS pos late 
                 57434 
               
               
                 2517 
                 LC/MS pos late 
                 57437 
               
               
                 2518 
                 LC/MS pos late 
                 57443 
               
               
                 2520 
                 LC/MS pos late 
                 57418 
                   
                   
                 6E+06 
               
               
                 2522 
                 LC/MS pos late 
                 53013 
               
               
                 2523 
                 LC/MS pos late 
                 52234 
               
               
                 2525 
                 LC/MS pos late 
                 57371 
               
               
                 2543 
                 LC/MS pos late 
                 57595 
               
               
                 2547 
                 LC/MS pos late 
                 57453 
               
               
                 2549 
                 LC/MS pos late 
                 53010 
               
               
                 2561 
                 LC/MS pos late 
                 52434 
                   
                   
                 1E+07 
               
               
                 2563 
                 LC/MS pos late 
                 57473 
                   
                 HMDB12087 
               
               
                 2564 
                 LC/MS pos late 
                 57476 
               
               
                 2565 
                 LC/MS pos late 
                 37506 
                   
                   
                 1E+07 
               
               
                 2566 
                 LC/MS pos late 
                 62851 
               
               
                 2567 
                 LC/MS pos late 
                 19503 
                 C00550 
                 HMDB01348 
                 6E+06 
               
               
                 2568 
                 LC/MS pos late 
                 48492 
                   
                 HMDB12103 
               
               
                 2569 
                 LC/MS pos late 
                 52436 
                   
                 HMDB12105 
               
               
                 2570 
                 LC/MS pos late 
                 57330 
               
               
                 2575 
                 LC/MS pos late 
                 42463 
                   
                 HMDB12097 
                 1E+07 
               
               
                 2577 
                 LC/MS pos late 
                 52433 
               
               
                 2579 
                 LC/MS pos late 
                 42459 
               
               
                 2580 
                 LC/MS pos late 
                 52615 
               
               
                 2581 
                 LC/MS pos late 
                 37529 
                   
                 HMDB12101 
                 6E+06 
               
               
                 2583 
                 LC/MS pos late 
                 48490 
                   
                 HMDB12102 
               
               
                 2588 
                 LC/MS pos late 
                 48493 
                   
                 HMDB12104 
               
               
                 2591 
                 LC/MS pos late 
                 47153 
                   
                 HMDB12107 
               
               
                 2592 
                 LC/MS pos late 
                 52437 
               
               
                 2594 
                 LC/MS pos late 
                 17747 
                 C00319 
                 HMDB00252 
                 5E+06 
               
               
                 2610 
                 LC/MS polar 
                 531 
                 C03761 
                 HMDB00355 
                 1662 
               
               
                 2624 
                 LC/MS pos late 
                 6065 
                 C01802 
                 HMDB02719 
                 439577 
               
               
                 2625 
                 LC/MS pos late 
                 63 
                 C00187 
                 HMDB00067 
                 1E+07 
               
               
                 2649 
                 LC/MS pos late 
                 38125 
                 C00599 
                 HMDB00921 
                 91477 
               
               
                 2652 
                 LC/MS pos late 
                 33997 
                 C01789 
                 HMDB02869 
                 173183 
               
               
                 2669 
                 LC/MS pos late 
                 47890 
                   
                 HMDB06119 
                 107722 
               
               
                 3453 
                 LC/MS pos early 
                 2133 
                 C00130 
                 HMDB00175 
                 8582 
               
               
                 3454 
                 LC/MS neg 
                 1123 
                 C00294 
                 HMDB00195 
                 6021 
               
               
                 3455 
                 LC/MS pos early 
                 3127 
                 C00262 
                 HMDB00157 
                 790 
               
               
                 3456 
                 LC/MS pos early 
                 3147 
                 C00385 
                 HMDB00292 
                 1188 
               
               
                 3458 
                 LC/MS neg 
                 15136 
                 C01762 
                 HMDB00299 
                 64959 
               
               
                 3461 
                 LC/MS pos early 
                 48351 
                   
                 HMDB02721 
                 65095 
               
               
                 3462 
                 LC/MS neg 
                 15076 
                 C05512 
                 HMDB00071 
                 65058 
               
               
                 3464 
                 LC/MS neg 
                 1604 
                 C00366 
                 HMDB00289 
                 1175 
               
               
                 3466 
                 LC/MS pos early 
                 1107 
                 C02350 
                 HMDB00462 
                 204 
               
               
                 3471 
                 LC/MS neg 
                 3108 
                 C00008 
                 HMDB01341 
                 6022 
               
               
                 3472 
                 LC/MS pos early 
                 32342 
                 C00020 
                 HMDB00045 
                 6083 
               
               
                 3473 
                 LC/MS neg 
                 35142 
                 C01367 
                 HMDB03540 
                 41211 
               
               
                 3474 
                 LC/MS neg 
                 36815 
                 C00946 
                 HMDB11617 
                 94136 
               
               
                 3478 
                 LC/MS neg 
                 57838 
                 C03794 
                 HMDB00536 
                 195 
               
               
                 3479 
                 LC/MS pos early 
                 555 
                 C00212 
                 HMDB00050 
                 60961 
               
               
                 3480 
                 LC/MS pos early 
                 554 
                 C00147 
                 HMDB00034 
                 190 
               
               
                 3485 
                 LC/MS pos early 
                 15650 
                 C02494 
                 HMDB03331 
                 27476 
               
               
                 3495 
                 LC/MS neg 
                 35157 
                   
                 HMDB41623 
                 161466 
               
               
                 3498 
                 LC/MS neg 
                 46333 
                 C00360 
                 HMDB00905 
                 12599 
               
               
                 3505 
                 LC/MS pos early 
                 48130 
                   
                 HMDB00912 
                 165243 
               
               
                 3507 
                 LC/MS neg 
                 2848 
                 C00035 
                 HMDB01201 
                 8977 
               
               
                 3508 
                 LC/MS pos early 
                 2849 
                 C00144 
                 HMDB01397 
                 6804 
               
               
                 3513 
                 LC/MS pos early 
                 1573 
                 C00387 
                 HMDB00133 
                 6802 
               
               
                 3514 
                 LC/MS pos early 
                 32352 
                 C00242 
                 HMDB00132 
                 764 
               
               
                 3516 
                 LC/MS pos early 
                 35114 
                 C02242 
                 HMDB00897 
                 11361 
               
               
                 3522 
                 LC/MS pos early 
                 35137 
                   
                 HMDB04824 
                 92919 
               
               
                 3528 
                 LC/MS pos early 
                 35662 
                 C00362 
                 HMDB01044 
                 65059 
               
               
                 3530 
                 LC/MS neg 
                 1411 
                 C00330 
                 HMDB00085 
                 187790 
               
               
                 3533 
                 LC/MS polar 
                 1594 
                 C00438 
                 HMDB00828 
                 93072 
               
               
                 3534 
                 LC/MS polar 
                 601 
                 C00337 
                 HMDB03349 
                 648 
               
               
                 3535 
                 LC/MS polar 
                 1505 
                 C00295 
                 HMDB00226 
                 967 
               
               
                 3537 
                 LC/MS polar 
                 35172 
                   
                 HMDB00788 
                 92751 
               
               
                 3541 
                 LC/MS neg 
                 5345 
                 C00015 
                 HMDB00295 
                 6031 
               
               
                 3542 
                 LC/MS pos early 
                 2856 
                 C00105 
                 HMDB00288 
                 6030 
               
               
                 3547 
                 LC/MS neg 
                 606 
                 C00299 
                 HMDB00296 
                 6029 
               
               
                 3548 
                 LC/MS neg 
                 605 
                 C00106 
                 HMDB00300 
                 1174 
               
               
                 3549 
                 LC/MS neg 
                 33442 
                 C02067 
                 HMDB00767 
                 15047 
               
               
                 3550 
                 LC/MS neg 
                 61833 
                   
                   
                 94312 
               
               
                 3552 
                 LC/MS neg 
                 35136 
                   
                 HMDB00884 
                 445408 
               
               
                 3563 
                 LC/MS neg 
                 52602 
                 C00526 
                 HMDB00012 
                 13712 
               
               
                 3565 
                 LC/MS pos early 
                 57549 
                 C05100 
                 HMDB02031 
                 160663 
               
               
                 3566 
                 LC/MS pos early 
                 3155 
                 C02642 
                 HMDB00026 
                 111 
               
               
                 3567 
                 LC/MS pos early 
                 55 
                 C00099 
                 HMDB00056 
                 239 
               
               
                 3568 
                 LC/MS polar 
                 37432 
                 C01073 
                   
                 76406 
               
               
                 3572 
                 LC/MS neg 
                 2841 
                 C00112 
                 HMDB01546 
                 6132 
               
               
                 3573 
                 LC/MS pos early 
                 2372 
                 C00055 
                 HMDB00095 
                 6131 
               
               
                 3576 
                 LC/MS neg 
                 37465 
                 C02354 
                 HMDB11691 
                 417654 
               
               
                 3577 
                 LC/MS pos early 
                 514 
                 C00475 
                 HMDB00089 
                 6175 
               
               
                 3578 
                 LC/MS pos early 
                 573 
                 C00380 
                 HMDB00630 
                 597 
               
               
                 3579 
                 LC/MS pos early 
                 35132 
                   
                   
                 159649 
               
               
                 3580 
                 LC/MS pos early 
                 22119 
                   
                 HMDB00982 
                 92918 
               
               
                 3585 
                 LC/MS pos early 
                 533 
                 C00239 
                 HMDB01202 
                 13945 
               
               
                 3587 
                 LC/MS pos early 
                 15949 
                 C00881 
                 HMDB00014 
                 13711 
               
               
                 3588 
                 LC/MS pos early 
                 57554 
                   
                   
                 150971 
               
               
                 3589 
                 LC/MS pos early 
                 38159 
                 C03592 
                 HMDB02224 
                 440055 
               
               
                 3598 
                 LC/MS neg 
                 2183 
                 C00214 
                 HMDB00273 
                 5789 
               
               
                 3599 
                 LC/MS neg 
                 604 
                 C00178 
                 HMDB00262 
                 1135 
               
               
                 3602 
                 LC/MS pos early 
                 1566 
                 C05145 
                 HMDB03911 
                 64956 
               
               
                 3603 
                 LC/MS pos early 
                 37070 
                   
                 HMDB61711 
                 13130 
               
               
                 3607 
                 LC/MS neg 
                 52740 
                   
                   
                 112074 
               
               
                 3608 
                 LC/MS neg 
                 62396 
                   
                   
                 94231 
               
               
                 3624 
                 LC/MS pos early 
                 594 
                 C00153 
                 HMDB01406 
                 936 
               
               
                 3627 
                 LC/MS pos early 
                 33013 
                 C03150 
                 HMDB00855 
                 439924 
               
               
                 3628 
                 LC/MS neg 
                 5278 
                 C00003 
                 HMDB00902 
                 5893 
               
               
                 3636 
                 LC/MS pos early 
                 27665 
                 C02918 
                 HMDB00699 
                 1E+07 
               
               
                 3641 
                 LC/MS pos early 
                 32401 
                 C01004 
                 HMDB00875 
                 5570 
               
               
                 3643 
                 LC/MS neg 
                 40469 
                 C05842 
                 HMDB04193 
                 69698 
               
               
                 3644 
                 LC/MS pos early 
                 57584 
                 C05843 
                 HMDB04194 
                 440810 
               
               
                 3648 
                 LC/MS neg 
                 1827 
                 C00255 
                 HMDB00244 
                 493570 
               
               
                 3649 
                 LC/MS neg 
                 2134 
                 C00016 
                 HMDB01248 
                 643975 
               
               
                 3650 
                 LC/MS neg 
                 15797 
                 C00061 
                 HMDB01520 
                 710 
               
               
                 3651 
                 LC/MS pos early 
                 1508 
                 C00864 
                 HMDB00210 
                 6613 
               
               
                 3653 
                 LC/MS neg 
                 15504 
                 C01134 
                 HMDB01416 
                 987 
               
               
                 3654 
                 LC/MS neg 
                 18289 
                 C00882 
                 HMDB01373 
                 444485 
               
               
                 3656 
                 LC/MS neg 
                 46322 
                 C00010 
                 HMDB01423 
                 317 
               
               
                 3658 
                 LC/MS polar 
                 57555 
                 C00831 
                   
                 439322 
               
               
                 3662 
                 LC/MS pos early 
                 32354 
                 C00072 
                 HMDB00044 
               
               
                 3663 
                 LC/MS polar 
                 1659 
                 C05422 
                 HMDB01264 
                 835 
               
               
                 3664 
                 LC/MS polar 
                 27738 
                 C01620 
                 HMDB00943 
                 151152 
               
               
                 3667 
                 LC/MS neg 
                 20694 
                 C00209 
                 HMDB02329 
                 971 
               
               
                 3668 
                 LC/MS polar 
                 46957 
                 C00257 
                 HMDB03290 
                 1E+07 
               
               
                 3670 
                 LC/MS pos late 
                 1561 
                 C02477 
                 HMDB01893 
                 14985 
               
               
                 3694 
                 LC/MS pos early 
                 568 
                 C00120 
                 HMDB00030 
                 171548 
               
               
                 3698 
                 LC/MS neg 
                 18330 
                 C00440 
                 HMDB01396 
                 146 
               
               
                 3714 
                 LC/MS pos late 
                 41754 
                 C00032 
                 HMDB03178 
                 26945 
               
               
                 3715 
                 LC/MS pos late 
                 43807 
                 C00486 
                 HMDB00054 
                 5E+06 
               
               
                 3718 
                 LC/MS pos late 
                 2137 
                 C00500 
                 HMDB01008 
                 5E+06 
               
               
                 3727 
                 LC/MS pos early 
                 5341 
                 C00378 
                 HMDB00235 
                 1130 
               
               
                 3728 
                 LC/MS neg 
                 15798 
                 C01081 
                 HMDB02666 
                 3E+06 
               
               
                 3751 
                 LC/MS pos early 
                 2150 
                 C00534 
                 HMDB01431 
                 1052 
               
               
                 3754 
                 LC/MS pos early 
                 1651 
                 C00250 
                 HMDB01545 
                 1050 
               
               
                 3757 
                 LC/MS neg 
                 15753 
                 C01586 
                 HMDB00714 
                 464 
               
               
                 3771 
                 LC/MS neg 
                 15778 
                 C00180 
                 HMDB01870 
                 243 
               
               
                 3978 
                 LC/MS pos early 
                 62863 
                 C08493 
                 HMDB29737 
                 10256 
               
               
                 4000 
                 LC/MS polar 
                 587 
                 C00257 
                 HMDB00625 
                 10690 
               
               
                 4079 
                 LC/MS pos early 
                 37459 
                 C05570 
                 HMDB03045 
                 3E+06 
               
               
                 4108 
                 LC/MS pos early 
                 33009 
                 C08283 
                 HMDB33433 
                 441447 
               
               
                 4131 
                 LC/MS polar 
                 62864 
                   
                   
                 3E+06 
               
               
                 4144 
                 LC/MS pos early 
                 37123 
                 C03410 
                 HMDB00833 
                 123802 
               
               
                 4221 
                 LC/MS pos early 
                 34384 
                 C10172 
                 HMDB04827 
                 115244 
               
               
                 4246 
                 LC/MS neg 
                 46144 
               
               
                 4274 
                 LC/MS pos early 
                 48428 
                   
                 HMDB33143 
                 122228 
               
               
                 4363 
                 LC/MS neg 
                 20693 
                 C02287 
                 HMDB35227 
                 45 
               
               
                 4756 
                 LC/MS polar 
                 1515 
                 C00805 
                 HMDB01895 
                 338 
               
               
                 4832 
                 LC/MS neg 
                 46960 
                 C00059 
                 HMDB01448 
                 1118 
               
               
                 4835 
                 LC/MS neg 
                 45413 
                   
                   
                 514186 
               
               
                 4899 
                 LC/MS pos early 
                 35651 
                 C06231 
                   
                 126041 
               
               
                 4926 
                 LC/MS neg 
                 36817 
                 C12600 
                   
                 4766 
               
               
                 4930 
                 LC/MS polar 
                 57564 
                 C18142 
                 HMDB59586 
                 74483 
               
               
                 4971 
                 LC/MS pos early 
                 53231 
                   
                   
                 93176 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE 4C 
               
               
                   
               
               
                   
                 Sp/ 
                 ABX/ 
                 GF/ 
                 Sp/ 
                 GF/ 
                 GF/ 
                   
               
               
                 PSO 
                 SPF 
                 SPF 
                 SPF 
                 ABX 
                 ABX 
                 Sp 
                 GE 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 1 
                 0.83 
                 0.82 
                 0.94 
                 1.01 
                 1.15 
                 1.14 
                   
               
               
                 2 
                 0.91 
                 1.01 
                 1.38 
                 0.91 
                 1.37 
                 1.51 
               
               
                 5 
                 0.76 
                 0.69 
                 0.83 
                 1.10 
                 1.20 
                 1.09 
                 Y 
               
               
                 6 
                 0.81 
                 0.66 
                 0.80 
                 1.23 
                 1.21 
                 0.98 
                 Y 
               
               
                 9 
                 0.85 
                 1.07 
                 1.04 
                 0.79 
                 0.97 
                 1.23 
               
               
                 10 
                 0.80 
                 0.82 
                 0.90 
                 0.98 
                 1.10 
                 1.12 
                 Y 
               
               
                 14 
                 0.80 
                 1.01 
                 1.53 
                 0.79 
                 1.51 
                 1.91 
               
               
                 16 
                 0.79 
                 0.80 
                 0.92 
                 0.98 
                 1.14 
                 1.17 
               
               
                 17 
                 0.90 
                 0.84 
                 1.01 
                 1.07 
                 1.19 
                 1.12 
               
               
                 18 
                 0.79 
                 0.68 
                 0.82 
                 1.16 
                 1.21 
                 1.04 
               
               
                 21 
                 0.39 
                 0.29 
                 0.52 
                 1.32 
                 1.78 
                 1.35 
                 Y 
               
               
                 28 
                 0.82 
                 0.83 
                 0.86 
                 0.99 
                 1.04 
                 1.05 
                 y 
               
               
                 30 
                 0.82 
                 0.72 
                 0.83 
                 1.15 
                 1.16 
                 1.01 
                 Y 
               
               
                 34 
                 0.82 
                 0.81 
                 0.83 
                 1.01 
                 1.03 
                 1.01 
                 Y 
               
               
                 35 
                 0.79 
                 0.69 
                 0.73 
                 1.15 
                 1.06 
                 0.92 
                 Y 
               
               
                 38 
                 0.95 
                 0.95 
                 0.96 
                 1.00 
                 1.01 
                 1.01 
               
               
                 39 
                 0.92 
                 0.87 
                 0.98 
                 1.06 
                 1.13 
                 1.07 
               
               
                 40 
                 0.69 
                 0.55 
                 0.56 
                 1.27 
                 1.03 
                 0.81 
                 Y 
               
               
                 41 
                 0.87 
                 0.84 
                 0.86 
                 1.04 
                 1.03 
                 0.99 
                 Y 
               
               
                 42 
                 0.86 
                 0.70 
                 0.67 
                 1.23 
                 0.96 
                 0.78 
                 Y 
               
               
                 43 
                 1.87 
                 0.77 
                 0.63 
                 2.42 
                 0.81 
                 0.34 
                 Y 
               
               
                 44 
                 0.77 
                 0.76 
                 0.75 
                 1.02 
                 1.00 
                 0.98 
                 y 
               
               
                 45 
                 0.83 
                 0.70 
                 0.69 
                 1.18 
                 0.97 
                 0.83 
                 Y 
               
               
                 47 
                 0.64 
                 1.04 
                 1.05 
                 0.61 
                 1.01 
                 1.65 
                 Y 
               
               
                 50 
                 0.82 
                 0.71 
                 0.84 
                 1.16 
                 1.19 
                 1.02 
               
               
                 51 
                 0.97 
                 0.73 
                 0.51 
                 1.34 
                 0.70 
                 0.52 
                 Y 
               
               
                 52 
                 0.84 
                 0.80 
                 0.74 
                 1.05 
                 0.93 
                 0.88 
                 Y 
               
               
                 53 
                 0.88 
                 0.85 
                 0.81 
                 1.04 
                 0.95 
                 0.92 
                 Y 
               
               
                 54 
                 0.80 
                 0.75 
                 0.72 
                 1.06 
                 0.96 
                 0.90 
                 Y 
               
               
                 55 
                 0.83 
                 0.88 
                 0.60 
                 0.94 
                 0.68 
                 0.72 
               
               
                 56 
                 0.76 
                 1.22 
                 0.72 
                 0.62 
                 0.59 
                 0.95 
               
               
                 59 
                 0.81 
                 1.70 
                 0.63 
                 0.47 
                 0.37 
                 0.78 
                 y 
               
               
                 65 
                 0.96 
                 1.14 
                 0.96 
                 0.85 
                 0.85 
                 1.00 
               
               
                 66 
                 0.81 
                 1.35 
                 0.81 
                 0.60 
                 0.60 
                 1.00 
                 Y 
               
               
                 67 
                 0.73 
                 1.01 
                 0.70 
                 0.72 
                 0.70 
                 0.96 
               
               
                 68 
                 0.70 
                 0.94 
                 1.02 
                 0.74 
                 1.08 
                 1.46 
                 y 
               
               
                 74 
                 1.60 
                 0.33 
                 0.33 
                 4.81 
                 0.99 
                 0.20 
                 Y 
               
               
                 75 
                 1.22 
                 1.80 
                 1.53 
                 0.68 
                 0.85 
                 1.26 
                 y 
               
               
                 76 
                 0.90 
                 0.81 
                 0.76 
                 1.11 
                 0.94 
                 0.84 
                 Y 
               
               
                 77 
                 0.39 
                 0.34 
                 0.52 
                 1.15 
                 1.53 
                 1.33 
                 Y 
               
               
                 80 
                 0.82 
                 0.40 
                 0.42 
                 2.04 
                 1.04 
                 0.51 
                 Y 
               
               
                 82 
                 0.42 
                 0.27 
                 0.22 
                 1.54 
                 0.82 
                 0.53 
                 y 
               
               
                 83 
                 0.51 
                 0.36 
                 0.41 
                 1.42 
                 1.15 
                 0.81 
                 y 
               
               
                 84 
                 0.33 
                 0.43 
                 0.36 
                 0.76 
                 0.85 
                 1.11 
                 Y 
               
               
                 92 
                 0.89 
                 0.90 
                 0.94 
                 0.98 
                 1.04 
                 1.06 
               
               
                 93 
                 0.88 
                 0.49 
                 0.58 
                 1.80 
                 1.18 
                 0.66 
                 Y 
               
               
                 99 
                 0.86 
                 0.64 
                 0.57 
                 1.35 
                 0.89 
                 0.66 
                 Y 
               
               
                 100 
                 0.75 
                 0.57 
                 0.57 
                 1.30 
                 0.99 
                 0.76 
                 Y 
               
               
                 101 
                 0.73 
                 0.61 
                 0.65 
                 1.19 
                 1.06 
                 0.90 
                 Y 
               
               
                 102 
                 0.66 
                 0.79 
                 0.66 
                 0.83 
                 0.83 
                 1.00 
                 Y 
               
               
                 103 
                 0.82 
                 0.77 
                 0.82 
                 1.07 
                 1.06 
                 0.99 
                 Y 
               
               
                 105 
                 0.85 
                 1.05 
                 1.07 
                 0.80 
                 1.02 
                 1.27 
               
               
                 107 
                 1.01 
                 1.09 
                 1.50 
                 0.93 
                 1.38 
                 1.49 
               
               
                 113 
                 0.75 
                 0.57 
                 0.47 
                 1.32 
                 0.83 
                 0.63 
                 Y 
               
               
                 114 
                 0.96 
                 1.02 
                 1.70 
                 0.94 
                 1.66 
                 1.77 
               
               
                 117 
                 0.98 
                 0.85 
                 0.60 
                 1.16 
                 0.71 
                 0.62 
               
               
                 119 
                 1.79 
                 0.09 
                 0.16 
                 19.45 
                 1.71 
                 0.09 
                 Y 
               
               
                 120 
                 0.90 
                 0.82 
                 0.79 
                 1.10 
                 0.96 
                 0.88 
                 Y 
               
               
                 121 
                 1.09 
                 0.83 
                 0.81 
                 1.31 
                 0.98 
                 0.74 
               
               
                 122 
                 0.95 
                 0.79 
                 0.82 
                 1.19 
                 1.03 
                 0.87 
               
               
                 126 
                 0.73 
                 0.60 
                 0.58 
                 1.22 
                 0.96 
                 0.79 
                 y 
               
               
                 137 
                 0.97 
                 0.89 
                 0.79 
                 1.10 
                 0.90 
                 0.82 
                 y 
               
               
                 138 
                 0.85 
                 0.75 
                 0.52 
                 1.14 
                 0.70 
                 0.61 
                 Y 
               
               
                 150 
                 1.01 
                 0.81 
                 0.79 
                 1.24 
                 0.97 
                 0.78 
                 Y 
               
               
                 154 
                 0.63 
                 0.44 
                 0.44 
                 1.43 
                 1.00 
                 0.70 
                 Y 
               
               
                 180 
                 0.91 
                 0.95 
                 1.00 
                 0.96 
                 1.04 
                 1.09 
               
               
                 181 
                 0.88 
                 0.91 
                 1.07 
                 0.97 
                 1.19 
                 1.22 
               
               
                 191 
                 0.98 
                 0.40 
                 0.77 
                 2.41 
                 1.90 
                 0.79 
               
               
                 210 
                 0.79 
                 0.81 
                 0.77 
                 0.98 
                 0.95 
                 0.97 
                 Y 
               
               
                 217 
                 0.78 
                 0.71 
                 0.73 
                 1.11 
                 1.03 
                 0.93 
                 Y 
               
               
                 221 
                 0.91 
                 0.86 
                 0.82 
                 1.06 
                 0.95 
                 0.89 
               
               
                 227 
                 0.85 
                 0.34 
                 0.88 
                 2.49 
                 2.60 
                 1.04 
               
               
                 241 
                 0.74 
                 0.48 
                 0.59 
                 1.56 
                 1.24 
                 0.80 
               
               
                 254 
                 0.56 
                 0.31 
                 0.08 
                 1.79 
                 0.25 
                 0.14 
                 Y 
               
               
                 261 
                 0.86 
                 0.82 
                 0.81 
                 1.04 
                 0.98 
                 0.95 
                 y 
               
               
                 263 
                 0.92 
                 0.78 
                 0.97 
                 1.18 
                 1.24 
                 1.05 
               
               
                 265 
                 1.33 
                 1.28 
                 1.26 
                 1.04 
                 0.98 
                 0.95 
               
               
                 273 
                 0.95 
                 0.90 
                 1.12 
                 1.05 
                 1.25 
                 1.18 
               
               
                 280 
                 0.72 
                 0.89 
                 0.80 
                 0.81 
                 0.90 
                 1.11 
                 Y 
               
               
                 296 
                 0.87 
                 0.77 
                 0.77 
                 1.13 
                 1.01 
                 0.89 
                 Y 
               
               
                 299 
                 1.15 
                 0.75 
                 0.66 
                 1.54 
                 0.89 
                 0.58 
               
               
                 300 
                 1.35 
                 0.96 
                 1.21 
                 1.40 
                 1.26 
                 0.90 
               
               
                 301 
                 0.64 
                 0.83 
                 0.71 
                 0.77 
                 0.85 
                 1.10 
                 Y 
               
               
                 303 
                 0.95 
                 0.90 
                 0.97 
                 1.05 
                 1.07 
                 1.02 
               
               
                 306 
                 0.87 
                 0.83 
                 0.87 
                 1.04 
                 1.05 
                 1.01 
               
               
                 311 
                 0.89 
                 0.69 
                 0.81 
                 1.30 
                 1.18 
                 0.90 
                 Y 
               
               
                 312 
                 0.72 
                 0.67 
                 0.77 
                 1.08 
                 1.15 
                 1.06 
                 Y 
               
               
                 318 
                 0.87 
                 0.85 
                 0.91 
                 1.02 
                 1.07 
                 1.05 
               
               
                 321 
                 0.95 
                 0.69 
                 0.88 
                 1.37 
                 1.27 
                 0.92 
                 y 
               
               
                 323 
                 1.23 
                 1.13 
                 1.21 
                 1.09 
                 1.07 
                 0.98 
               
               
                 326 
                 1.01 
                 1.03 
                 1.20 
                 0.99 
                 1.17 
                 1.18 
               
               
                 328 
                 0.80 
                 0.76 
                 1.02 
                 1.06 
                 1.34 
                 1.27 
               
               
                 332 
                 0.74 
                 0.68 
                 0.69 
                 1.09 
                 1.02 
                 0.94 
                 Y 
               
               
                 333 
                 1.03 
                 0.69 
                 0.89 
                 1.49 
                 1.28 
                 0.86 
                 Y 
               
               
                 334 
                 0.82 
                 0.86 
                 0.85 
                 0.95 
                 0.98 
                 1.03 
                 y 
               
               
                 337 
                 0.77 
                 0.47 
                 0.73 
                 1.65 
                 1.57 
                 0.95 
                 Y 
               
               
                 342 
                 0.87 
                 0.79 
                 0.77 
                 1.09 
                 0.97 
                 0.89 
                 Y 
               
               
                 343 
                 0.82 
                 0.91 
                 0.81 
                 0.90 
                 0.89 
                 0.98 
               
               
                 349 
                 0.70 
                 0.53 
                 0.70 
                 1.31 
                 1.31 
                 1.00 
                 Y 
               
               
                 351 
                 0.68 
                 1.04 
                 0.66 
                 0.66 
                 0.63 
                 0.96 
                 y 
               
               
                 353 
                 0.67 
                 1.21 
                 1.04 
                 0.55 
                 0.86 
                 1.56 
               
               
                 362 
                 0.80 
                 0.86 
                 0.98 
                 0.92 
                 1.14 
                 1.23 
               
               
                 363 
                 0.80 
                 0.96 
                 0.98 
                 0.84 
                 1.02 
                 1.22 
                 Y 
               
               
                 364 
                 0.84 
                 0.80 
                 0.77 
                 1.05 
                 0.97 
                 0.92 
                 Y 
               
               
                 365 
                 0.92 
                 0.74 
                 0.94 
                 1.25 
                 1.27 
                 1.01 
               
               
                 367 
                 0.64 
                 0.71 
                 0.54 
                 0.89 
                 0.75 
                 0.84 
                 Y 
               
               
                 369 
                 0.92 
                 0.37 
                 0.40 
                 2.49 
                 1.08 
                 0.43 
                 Y 
               
               
                 371 
                 0.88 
                 0.88 
                 0.93 
                 1.00 
                 1.06 
                 1.06 
               
               
                 372 
                 0.76 
                 0.82 
                 0.86 
                 0.93 
                 1.05 
                 1.12 
               
               
                 373 
                 0.98 
                 0.79 
                 0.87 
                 1.25 
                 1.11 
                 0.89 
               
               
                 375 
                 0.84 
                 0.77 
                 0.92 
                 1.08 
                 1.19 
                 1.11 
               
               
                 379 
                 0.82 
                 0.80 
                 0.78 
                 1.02 
                 0.97 
                 0.95 
               
               
                 380 
                 0.82 
                 0.78 
                 0.71 
                 1.05 
                 0.92 
                 0.88 
               
               
                 381 
                 0.90 
                 0.86 
                 0.77 
                 1.06 
                 0.90 
                 0.85 
               
               
                 382 
                 0.95 
                 0.84 
                 0.52 
                 1.13 
                 0.62 
                 0.55 
                 Y 
               
               
                 383 
                 0.82 
                 0.87 
                 0.93 
                 0.94 
                 1.06 
                 1.13 
               
               
                 386 
                 1.07 
                 0.89 
                 0.93 
                 1.21 
                 1.05 
                 0.87 
               
               
                 387 
                 0.84 
                 0.86 
                 0.80 
                 0.98 
                 0.93 
                 0.96 
               
               
                 392 
                 1.01 
                 0.75 
                 0.40 
                 1.35 
                 0.54 
                 0.40 
                 Y 
               
               
                 397 
                 0.86 
                 0.93 
                 0.91 
                 0.92 
                 0.97 
                 1.06 
                 Y 
               
               
                 399 
                 0.81 
                 0.67 
                 0.69 
                 1.22 
                 1.03 
                 0.85 
                 Y 
               
               
                 405 
                 0.68 
                 0.70 
                 0.65 
                 0.97 
                 0.93 
                 0.96 
               
               
                 410 
                 0.91 
                 0.88 
                 1.00 
                 1.03 
                 1.13 
                 1.09 
               
               
                 411 
                 0.88 
                 0.82 
                 0.83 
                 1.07 
                 1.01 
                 0.94 
                 Y 
               
               
                 412 
                 0.88 
                 0.83 
                 0.93 
                 1.06 
                 1.12 
                 1.06 
               
               
                 418 
                 0.91 
                 0.99 
                 0.93 
                 0.93 
                 0.94 
                 1.01 
               
               
                 421 
                 0.71 
                 0.77 
                 0.73 
                 0.93 
                 0.94 
                 1.02 
                 y 
               
               
                 426 
                 0.68 
                 0.74 
                 0.70 
                 0.92 
                 0.95 
                 1.03 
               
               
                 429 
                 0.92 
                 0.79 
                 0.84 
                 1.16 
                 1.06 
                 0.92 
               
               
                 430 
                 1.16 
                 0.94 
                 1.10 
                 1.23 
                 1.17 
                 0.95 
               
               
                 436 
                 1.01 
                 0.68 
                 0.97 
                 1.47 
                 1.41 
                 0.96 
                 Y 
               
               
                 438 
                 0.72 
                 0.72 
                 0.72 
                 1.00 
                 1.00 
                 1.00 
               
               
                 439 
                 0.72 
                 0.83 
                 0.82 
                 0.87 
                 0.98 
                 1.13 
                 y 
               
               
                 442 
                 0.75 
                 1.06 
                 0.66 
                 0.71 
                 0.62 
                 0.88 
               
               
                 443 
                 0.84 
                 0.87 
                 0.83 
                 0.96 
                 0.95 
                 0.99 
               
               
                 445 
                 1.10 
                 0.21 
                 1.00 
                 5.28 
                 4.83 
                 0.92 
               
               
                 446 
                 0.77 
                 0.82 
                 0.84 
                 0.94 
                 1.03 
                 1.10 
                 Y 
               
               
                 447 
                 0.66 
                 1.50 
                 0.46 
                 0.44 
                 0.31 
                 0.70 
                 Y 
               
               
                 451 
                 0.74 
                 0.65 
                 0.63 
                 1.13 
                 0.97 
                 0.86 
                 Y 
               
               
                 454 
                 0.95 
                 1.37 
                 2.06 
                 0.69 
                 1.51 
                 2.18 
               
               
                 456 
                 0.56 
                 0.72 
                 0.92 
                 0.77 
                 1.29 
                 1.66 
                 Y 
               
               
                 459 
                 1.35 
                 0.13 
                 0.96 
                 10.23 
                 7.30 
                 0.71 
                 Y 
               
               
                 460 
                 0.94 
                 0.89 
                 0.72 
                 1.06 
                 0.82 
                 0.77 
               
               
                 461 
                 0.91 
                 1.14 
                 1.02 
                 0.80 
                 0.90 
                 1.12 
               
               
                 465 
                 0.48 
                 0.81 
                 0.63 
                 0.59 
                 0.78 
                 1.32 
                 y 
               
               
                 467 
                 0.60 
                 0.77 
                 0.56 
                 0.78 
                 0.73 
                 0.94 
                 Y 
               
               
                 468 
                 0.67 
                 0.78 
                 0.59 
                 0.86 
                 0.76 
                 0.88 
                 Y 
               
               
                 469 
                 0.53 
                 0.79 
                 0.66 
                 0.67 
                 0.84 
                 1.25 
                 Y 
               
               
                 471 
                 0.91 
                 0.89 
                 0.75 
                 1.01 
                 0.84 
                 0.83 
               
               
                 472 
                 0.86 
                 0.81 
                 0.84 
                 1.07 
                 1.04 
                 0.97 
               
               
                 473 
                 0.94 
                 0.79 
                 1.11 
                 1.19 
                 1.40 
                 1.18 
               
               
                 474 
                 0.78 
                 0.66 
                 0.75 
                 1.18 
                 1.14 
                 0.97 
                 Y 
               
               
                 475 
                 0.61 
                 0.82 
                 0.60 
                 0.74 
                 0.72 
                 0.98 
                 y 
               
               
                 476 
                 1.01 
                 0.81 
                 0.86 
                 1.25 
                 1.06 
                 0.85 
               
               
                 477 
                 0.74 
                 0.74 
                 0.77 
                 1.00 
                 1.04 
                 1.04 
                 y 
               
               
                 478 
                 0.57 
                 0.73 
                 0.58 
                 0.77 
                 0.80 
                 1.03 
                 Y 
               
               
                 479 
                 0.87 
                 0.66 
                 0.63 
                 1.33 
                 0.95 
                 0.72 
                 y 
               
               
                 480 
                 0.90 
                 0.88 
                 0.86 
                 1.02 
                 0.97 
                 0.96 
               
               
                 756 
                 0.90 
                 0.74 
                 0.81 
                 1.21 
                 1.09 
                 0.90 
               
               
                 929 
                 0.80 
                 0.45 
                 0.45 
                 1.79 
                 1.00 
                 0.56 
                 Y 
               
               
                 955 
                 0.53 
                 0.80 
                 2.04 
                 0.66 
                 2.54 
                 3.85 
                 Y 
               
               
                 958 
                 0.70 
                 0.58 
                 3.16 
                 1.20 
                 5.42 
                 4.51 
                 Y 
               
               
                 959 
                 0.77 
                 0.55 
                 0.74 
                 1.41 
                 1.34 
                 0.95 
                 Y 
               
               
                 965 
                 0.88 
                 0.58 
                 0.82 
                 1.51 
                 1.41 
                 0.93 
                 Y 
               
               
                 967 
                 0.74 
                 0.70 
                 0.69 
                 1.07 
                 0.99 
                 0.93 
                 Y 
               
               
                 972 
                 0.99 
                 0.85 
                 1.07 
                 1.17 
                 1.26 
                 1.08 
               
               
                 973 
                 0.99 
                 0.87 
                 1.14 
                 1.15 
                 1.32 
                 1.15 
               
               
                 974 
                 0.82 
                 0.76 
                 0.87 
                 1.08 
                 1.15 
                 1.06 
                 y 
               
               
                 975 
                 0.77 
                 0.73 
                 0.78 
                 1.05 
                 1.07 
                 1.02 
                 Y 
               
               
                 978 
                 1.10 
                 0.61 
                 1.14 
                 1.81 
                 1.87 
                 1.03 
               
               
                 981 
                 1.68 
                 0.60 
                 1.12 
                 2.81 
                 1.87 
                 0.66 
                 Y 
               
               
                 982 
                 0.80 
                 0.47 
                 0.79 
                 1.69 
                 1.66 
                 0.99 
               
               
                 983 
                 1.24 
                 1.23 
                 1.22 
                 1.00 
                 0.99 
                 0.98 
               
               
                 984 
                 1.13 
                 1.12 
                 1.12 
                 1.01 
                 1.00 
                 0.99 
               
               
                 986 
                 0.80 
                 0.68 
                 0.76 
                 1.17 
                 1.12 
                 0.95 
                 Y 
               
               
                 993 
                 0.73 
                 0.94 
                 0.87 
                 0.78 
                 0.93 
                 1.19 
                 y 
               
               
                 994 
                 0.72 
                 0.67 
                 0.83 
                 1.07 
                 1.23 
                 1.15 
                 Y 
               
               
                 995 
                 0.83 
                 0.86 
                 0.89 
                 0.97 
                 1.04 
                 1.07 
               
               
                 997 
                 0.74 
                 0.72 
                 0.68 
                 1.03 
                 0.94 
                 0.91 
                 Y 
               
               
                 1018 
                 0.87 
                 0.61 
                 0.77 
                 1.42 
                 1.25 
                 0.88 
                 Y 
               
               
                 1020 
                 0.71 
                 0.59 
                 0.66 
                 1.20 
                 1.12 
                 0.93 
                 Y 
               
               
                 1023 
                 0.79 
                 0.66 
                 0.74 
                 1.20 
                 1.12 
                 0.93 
                 Y 
               
               
                 1024 
                 0.68 
                 0.79 
                 0.71 
                 0.85 
                 0.89 
                 1.04 
                 Y 
               
               
                 1028 
                 0.72 
                 0.58 
                 0.61 
                 1.24 
                 1.04 
                 0.84 
                 Y 
               
               
                 1030 
                 0.69 
                 0.53 
                 0.61 
                 1.30 
                 1.14 
                 0.88 
                 Y 
               
               
                 1033 
                 0.67 
                 0.52 
                 0.69 
                 1.28 
                 1.31 
                 1.02 
               
               
                 1073 
                 0.88 
                 0.64 
                 1.06 
                 1.38 
                 1.66 
                 1.20 
                 y 
               
               
                 1078 
                 0.76 
                 0.67 
                 0.70 
                 1.13 
                 1.04 
                 0.92 
                 Y 
               
               
                 1079 
                 0.62 
                 0.56 
                 0.87 
                 1.11 
                 1.56 
                 1.40 
                 Y 
               
               
                 1080 
                 0.78 
                 0.53 
                 0.77 
                 1.48 
                 1.46 
                 0.99 
                 Y 
               
               
                 1090 
                 0.66 
                 0.38 
                 0.64 
                 1.75 
                 1.71 
                 0.98 
                 y 
               
               
                 1099 
                 0.77 
                 0.74 
                 0.74 
                 1.03 
                 0.99 
                 0.96 
                 Y 
               
               
                 1104 
                 0.87 
                 0.80 
                 0.87 
                 1.09 
                 1.09 
                 1.00 
               
               
                 1108 
                 0.79 
                 0.72 
                 0.86 
                 1.10 
                 1.20 
                 1.09 
                 y 
               
               
                 1109 
                 0.98 
                 0.89 
                 0.91 
                 1.10 
                 1.01 
                 0.92 
                 y 
               
               
                 1111 
                 0.59 
                 0.39 
                 0.62 
                 1.53 
                 1.61 
                 1.05 
                 Y 
               
               
                 1115 
                 0.89 
                 0.81 
                 0.85 
                 1.10 
                 1.05 
                 0.96 
                 Y 
               
               
                 1116 
                 0.73 
                 0.68 
                 0.74 
                 1.07 
                 1.09 
                 1.02 
                 Y 
               
               
                 1123 
                 0.84 
                 0.50 
                 0.78 
                 1.68 
                 1.55 
                 0.92 
               
               
                 1127 
                 0.86 
                 0.83 
                 0.85 
                 1.04 
                 1.03 
                 0.99 
                 Y 
               
               
                 1131 
                 0.53 
                 0.53 
                 0.59 
                 1.00 
                 1.13 
                 1.12 
                 Y 
               
               
                 1132 
                 0.82 
                 1.10 
                 0.80 
                 0.74 
                 0.73 
                 0.98 
               
               
                 1138 
                 0.87 
                 0.84 
                 0.80 
                 1.03 
                 0.95 
                 0.93 
                 Y 
               
               
                 1149 
                 0.82 
                 0.80 
                 0.82 
                 1.03 
                 1.03 
                 0.99 
                 Y 
               
               
                 1150 
                 0.76 
                 0.74 
                 0.77 
                 1.02 
                 1.04 
                 1.01 
                 Y 
               
               
                 1152 
                 0.72 
                 0.70 
                 0.61 
                 1.02 
                 0.87 
                 0.86 
                 y 
               
               
                 1157 
                 1.03 
                 0.94 
                 1.10 
                 1.10 
                 1.18 
                 1.07 
               
               
                 1163 
                 1.16 
                 1.11 
                 1.35 
                 1.04 
                 1.21 
                 1.16 
               
               
                 1165 
                 0.65 
                 0.75 
                 0.71 
                 0.87 
                 0.94 
                 1.09 
                 Y 
               
               
                 1166 
                 1.03 
                 1.11 
                 1.37 
                 0.93 
                 1.23 
                 1.33 
               
               
                 1167 
                 0.78 
                 0.78 
                 0.77 
                 1.01 
                 0.99 
                 0.98 
                 y 
               
               
                 1169 
                 0.88 
                 0.81 
                 0.80 
                 1.09 
                 0.98 
                 0.90 
                 Y 
               
               
                 1179 
                 0.82 
                 0.79 
                 0.83 
                 1.05 
                 1.05 
                 1.01 
                 Y 
               
               
                 1181 
                 1.08 
                 0.93 
                 1.08 
                 1.16 
                 1.16 
                 1.00 
               
               
                 1183 
                 0.92 
                 0.89 
                 0.70 
                 1.02 
                 0.78 
                 0.76 
                 Y 
               
               
                 1201 
                 1.18 
                 1.09 
                 0.95 
                 1.08 
                 0.87 
                 0.81 
               
               
                 1203 
                 0.84 
                 1.06 
                 1.03 
                 0.80 
                 0.97 
                 1.22 
               
               
                 1204 
                 1.13 
                 1.41 
                 1.40 
                 0.80 
                 0.99 
                 1.24 
               
               
                 1205 
                 0.92 
                 0.96 
                 1.13 
                 0.96 
                 1.17 
                 1.23 
               
               
                 1217 
                 0.75 
                 0.95 
                 0.77 
                 0.79 
                 0.81 
                 1.02 
               
               
                 1218 
                 0.68 
                 0.86 
                 0.62 
                 0.79 
                 0.73 
                 0.92 
                 Y 
               
               
                 1223 
                 0.78 
                 0.96 
                 0.84 
                 0.81 
                 0.87 
                 1.08 
               
               
                 1225 
                 0.52 
                 0.90 
                 0.50 
                 0.58 
                 0.56 
                 0.97 
                 Y 
               
               
                 1236 
                 0.65 
                 0.97 
                 0.80 
                 0.68 
                 0.82 
                 1.22 
               
               
                 1239 
                 0.66 
                 0.84 
                 0.67 
                 0.79 
                 0.80 
                 1.02 
               
               
                 1244 
                 0.62 
                 1.17 
                 0.72 
                 0.53 
                 0.61 
                 1.16 
               
               
                 1247 
                 0.60 
                 0.85 
                 0.52 
                 0.71 
                 0.62 
                 0.87 
                 y 
               
               
                 1253 
                 0.76 
                 0.86 
                 0.82 
                 0.88 
                 0.96 
                 1.09 
                 Y 
               
               
                 1258 
                 0.60 
                 0.99 
                 0.54 
                 0.61 
                 0.55 
                 0.89 
                 Y 
               
               
                 1259 
                 0.47 
                 0.98 
                 0.42 
                 0.49 
                 0.43 
                 0.89 
                 Y 
               
               
                 1260 
                 0.43 
                 0.77 
                 0.37 
                 0.56 
                 0.48 
                 0.87 
                 Y 
               
               
                 1264 
                 0.38 
                 1.03 
                 0.32 
                 0.37 
                 0.31 
                 0.83 
               
               
                 1265 
                 0.49 
                 0.89 
                 0.54 
                 0.55 
                 0.61 
                 1.11 
                 Y 
               
               
                 1267 
                 0.76 
                 0.91 
                 0.71 
                 0.83 
                 0.78 
                 0.94 
               
               
                 1269 
                 0.41 
                 0.88 
                 0.44 
                 0.46 
                 0.49 
                 1.07 
                 Y 
               
               
                 1270 
                 0.45 
                 0.77 
                 0.42 
                 0.58 
                 0.54 
                 0.93 
                 Y 
               
               
                 1271 
                 0.61 
                 0.87 
                 0.57 
                 0.71 
                 0.65 
                 0.93 
               
               
                 1272 
                 0.51 
                 0.78 
                 0.49 
                 0.66 
                 0.63 
                 0.96 
               
               
                 1273 
                 0.52 
                 0.83 
                 0.65 
                 0.63 
                 0.79 
                 1.25 
               
               
                 1274 
                 0.51 
                 0.88 
                 0.53 
                 0.58 
                 0.60 
                 1.04 
                 y 
               
               
                 1276 
                 0.51 
                 1.09 
                 0.49 
                 0.47 
                 0.45 
                 0.95 
               
               
                 1277 
                 0.50 
                 0.94 
                 0.57 
                 0.52 
                 0.60 
                 1.14 
               
               
                 1351 
                 0.98 
                 0.68 
                 0.81 
                 1.45 
                 1.20 
                 0.83 
                 y 
               
               
                 1355 
                 0.79 
                 0.77 
                 0.79 
                 1.02 
                 1.03 
                 1.01 
                 Y 
               
               
                 1359 
                 0.74 
                 0.72 
                 0.70 
                 1.03 
                 0.98 
                 0.95 
                 y 
               
               
                 1360 
                 0.88 
                 0.80 
                 1.03 
                 1.10 
                 1.29 
                 1.17 
               
               
                 1363 
                 0.87 
                 0.85 
                 0.94 
                 1.02 
                 1.11 
                 1.08 
               
               
                 1372 
                 0.86 
                 1.08 
                 1.02 
                 0.80 
                 0.94 
                 1.18 
               
               
                 1430 
                 0.80 
                 0.73 
                 0.89 
                 1.09 
                 1.22 
                 1.12 
               
               
                 1446 
                 1.07 
                 0.93 
                 1.15 
                 1.15 
                 1.23 
                 1.07 
                 y 
               
               
                 1449 
                 0.91 
                 0.84 
                 0.96 
                 1.08 
                 1.14 
                 1.05 
               
               
                 1452 
                 0.97 
                 0.69 
                 0.89 
                 1.39 
                 1.29 
                 0.92 
                 Y 
               
               
                 1480 
                 0.94 
                 0.81 
                 0.99 
                 1.16 
                 1.22 
                 1.05 
                 Y 
               
               
                 1482 
                 0.79 
                 0.82 
                 1.14 
                 0.96 
                 1.39 
                 1.44 
               
               
                 1483 
                 0.80 
                 0.86 
                 0.90 
                 0.92 
                 1.04 
                 1.13 
               
               
                 1485 
                 1.26 
                 0.98 
                 1.50 
                 1.29 
                 1.53 
                 1.19 
                 Y 
               
               
                 1487 
                 0.95 
                 0.86 
                 0.91 
                 1.10 
                 1.06 
                 0.97 
               
               
                 1488 
                 1.45 
                 0.91 
                 1.74 
                 1.60 
                 1.92 
                 1.20 
                 Y 
               
               
                 1495 
                 1.37 
                 0.82 
                 1.77 
                 1.68 
                 2.17 
                 1.29 
                 Y 
               
               
                 1496 
                 1.24 
                 0.81 
                 1.19 
                 1.52 
                 1.46 
                 0.96 
                 Y 
               
               
                 1498 
                 1.03 
                 0.70 
                 0.91 
                 1.48 
                 1.30 
                 0.88 
                 Y 
               
               
                 1499 
                 1.25 
                 0.77 
                 1.34 
                 1.62 
                 1.74 
                 1.07 
                 Y 
               
               
                 1500 
                 0.90 
                 0.69 
                 0.77 
                 1.31 
                 1.13 
                 0.86 
                 Y 
               
               
                 1501 
                 1.22 
                 0.76 
                 1.66 
                 1.60 
                 2.17 
                 1.36 
                 Y 
               
               
                 1503 
                 0.73 
                 0.89 
                 0.59 
                 0.82 
                 0.66 
                 0.81 
                 Y 
               
               
                 1504 
                 1.07 
                 0.71 
                 1.14 
                 1.50 
                 1.60 
                 1.06 
                 Y 
               
               
                 1506 
                 1.50 
                 0.83 
                 1.90 
                 1.81 
                 2.29 
                 1.27 
                 Y 
               
               
                 1517 
                 1.03 
                 0.75 
                 0.83 
                 1.36 
                 1.10 
                 0.80 
                 Y 
               
               
                 1518 
                 0.92 
                 0.76 
                 0.96 
                 1.21 
                 1.27 
                 1.05 
               
               
                 1519 
                 0.86 
                 0.68 
                 0.93 
                 1.26 
                 1.36 
                 1.08 
                 y 
               
               
                 1521 
                 1.00 
                 0.99 
                 1.09 
                 1.01 
                 1.10 
                 1.09 
               
               
                 1522 
                 1.04 
                 0.77 
                 1.25 
                 1.34 
                 1.62 
                 1.21 
                 Y 
               
               
                 1523 
                 1.05 
                 0.76 
                 1.07 
                 1.39 
                 1.42 
                 1.02 
                 Y 
               
               
                 1524 
                 0.97 
                 0.69 
                 0.82 
                 1.40 
                 1.19 
                 0.85 
                 Y 
               
               
                 1527 
                 0.66 
                 0.71 
                 0.74 
                 0.94 
                 1.04 
                 1.12 
               
               
                 1528 
                 0.79 
                 0.82 
                 0.68 
                 0.97 
                 0.84 
                 0.86 
               
               
                 1529 
                 0.84 
                 0.82 
                 0.81 
                 1.03 
                 0.99 
                 0.96 
               
               
                 1536 
                 0.93 
                 0.73 
                 1.06 
                 1.28 
                 1.45 
                 1.13 
               
               
                 1537 
                 0.97 
                 0.73 
                 0.83 
                 1.34 
                 1.14 
                 0.85 
               
               
                 1539 
                 0.86 
                 0.82 
                 0.60 
                 1.04 
                 0.73 
                 0.70 
                 Y 
               
               
                 1541 
                 0.83 
                 0.73 
                 0.77 
                 1.13 
                 1.05 
                 0.93 
                 y 
               
               
                 1542 
                 0.95 
                 0.90 
                 0.95 
                 1.06 
                 1.05 
                 0.99 
               
               
                 1547 
                 0.82 
                 1.05 
                 3.32 
                 0.79 
                 3.16 
                 4.03 
                 Y 
               
               
                 1565 
                 0.96 
                 0.35 
                 0.77 
                 2.77 
                 2.23 
                 0.81 
               
               
                 1567 
                 1.02 
                 0.70 
                 0.93 
                 1.45 
                 1.32 
                 0.91 
               
               
                 1582 
                 1.08 
                 0.95 
                 0.97 
                 1.14 
                 1.02 
                 0.90 
               
               
                 1711 
                 0.69 
                 0.40 
                 0.64 
                 1.75 
                 1.61 
                 0.92 
               
               
                 1718 
                 0.78 
                 0.83 
                 0.72 
                 0.95 
                 0.87 
                 0.92 
                 Y 
               
               
                 1721 
                 0.88 
                 0.95 
                 0.92 
                 0.93 
                 0.98 
                 1.05 
               
               
                 1731 
                 0.63 
                 0.79 
                 0.63 
                 0.79 
                 0.80 
                 1.01 
               
               
                 1732 
                 0.47 
                 0.73 
                 0.47 
                 0.64 
                 0.65 
                 1.00 
                 y 
               
               
                 1744 
                 0.79 
                 0.84 
                 0.79 
                 0.94 
                 0.94 
                 1.00 
                 y 
               
               
                 1753 
                 0.74 
                 0.64 
                 0.60 
                 1.15 
                 0.93 
                 0.81 
                 Y 
               
               
                 1754 
                 1.70 
                 0.72 
                 0.90 
                 2.35 
                 1.24 
                 0.53 
                 Y 
               
               
                 1782 
                 0.70 
                 0.83 
                 0.72 
                 0.84 
                 0.86 
                 1.03 
                 Y 
               
               
                 1783 
                 0.92 
                 0.95 
                 0.97 
                 0.97 
                 1.02 
                 1.05 
               
               
                 1784 
                 0.94 
                 0.66 
                 0.77 
                 1.43 
                 1.18 
                 0.82 
                 Y 
               
               
                 1786 
                 1.02 
                 0.76 
                 0.94 
                 1.34 
                 1.24 
                 0.92 
                 Y 
               
               
                 1788 
                 0.88 
                 0.82 
                 0.80 
                 1.08 
                 0.98 
                 0.91 
                 Y 
               
               
                 1789 
                 0.87 
                 0.80 
                 0.82 
                 1.08 
                 1.02 
                 0.95 
                 Y 
               
               
                 1790 
                 0.95 
                 0.83 
                 0.89 
                 1.14 
                 1.07 
                 0.94 
                 Y 
               
               
                 1791 
                 0.83 
                 0.81 
                 0.75 
                 1.02 
                 0.93 
                 0.91 
                 y 
               
               
                 1792 
                 0.84 
                 0.87 
                 0.74 
                 0.96 
                 0.84 
                 0.88 
                 Y 
               
               
                 1793 
                 0.38 
                 0.08 
                 0.04 
                 4.61 
                 0.48 
                 0.10 
                 Y 
               
               
                 1811 
                 0.93 
                 0.88 
                 0.86 
                 1.07 
                 0.99 
                 0.93 
                 y 
               
               
                 1815 
                 0.82 
                 0.78 
                 0.80 
                 1.05 
                 1.03 
                 0.98 
                 y 
               
               
                 1827 
                 0.91 
                 0.86 
                 0.88 
                 1.05 
                 1.02 
                 0.97 
                 Y 
               
               
                 1828 
                 0.95 
                 0.93 
                 0.90 
                 1.03 
                 0.97 
                 0.95 
               
               
                 1829 
                 0.87 
                 0.73 
                 0.79 
                 1.18 
                 1.07 
                 0.91 
                 Y 
               
               
                 1831 
                 0.91 
                 0.87 
                 0.88 
                 1.05 
                 1.01 
                 0.96 
                 Y 
               
               
                 1834 
                 0.91 
                 0.99 
                 0.99 
                 0.92 
                 1.00 
                 1.09 
               
               
                 1837 
                 0.83 
                 0.93 
                 0.96 
                 0.89 
                 1.04 
                 1.16 
               
               
                 1841 
                 0.82 
                 0.97 
                 0.93 
                 0.84 
                 0.96 
                 1.14 
                 y 
               
               
                 1845 
                 0.89 
                 0.82 
                 0.84 
                 1.08 
                 1.02 
                 0.95 
                 Y 
               
               
                 1851 
                 0.76 
                 0.78 
                 0.66 
                 0.97 
                 0.85 
                 0.87 
                 Y 
               
               
                 1866 
                 0.66 
                 0.56 
                 0.44 
                 1.19 
                 0.79 
                 0.66 
                 Y 
               
               
                 1867 
                 0.88 
                 0.84 
                 0.79 
                 1.04 
                 0.93 
                 0.90 
                 Y 
               
               
                 1870 
                 0.85 
                 0.94 
                 0.99 
                 0.90 
                 1.05 
                 1.16 
               
               
                 1878 
                 0.86 
                 0.82 
                 0.77 
                 1.04 
                 0.93 
                 0.90 
                 Y 
               
               
                 1884 
                 0.79 
                 0.83 
                 0.69 
                 0.95 
                 0.84 
                 0.88 
                 Y 
               
               
                 1889 
                 0.97 
                 1.01 
                 0.91 
                 0.95 
                 0.90 
                 0.95 
               
               
                 1892 
                 0.81 
                 1.11 
                 1.17 
                 0.73 
                 1.06 
                 1.46 
                 Y 
               
               
                 1902 
                 0.75 
                 0.86 
                 0.67 
                 0.86 
                 0.77 
                 0.89 
                 Y 
               
               
                 1903 
                 0.54 
                 0.93 
                 0.94 
                 0.59 
                 1.02 
                 1.73 
                 Y 
               
               
                 1907 
                 0.78 
                 1.00 
                 0.99 
                 0.78 
                 1.00 
                 1.28 
               
               
                 1945 
                 0.90 
                 0.90 
                 0.85 
                 1.00 
                 0.95 
                 0.95 
                 y 
               
               
                 1948 
                 0.86 
                 0.78 
                 0.76 
                 1.10 
                 0.98 
                 0.89 
                 Y 
               
               
                 1949 
                 0.88 
                 0.91 
                 0.82 
                 0.97 
                 0.90 
                 0.94 
                 Y 
               
               
                 1950 
                 0.89 
                 1.10 
                 0.99 
                 0.81 
                 0.90 
                 1.12 
               
               
                 1953 
                 0.83 
                 0.92 
                 0.86 
                 0.91 
                 0.93 
                 1.03 
               
               
                 1955 
                 0.85 
                 0.94 
                 0.74 
                 0.90 
                 0.79 
                 0.88 
               
               
                 1962 
                 0.84 
                 0.85 
                 0.75 
                 0.99 
                 0.89 
                 0.89 
                 Y 
               
               
                 1970 
                 0.85 
                 0.90 
                 0.81 
                 0.95 
                 0.90 
                 0.94 
                 y 
               
               
                 1974 
                 0.80 
                 0.88 
                 0.69 
                 0.90 
                 0.79 
                 0.87 
                 Y 
               
               
                 1975 
                 0.89 
                 1.05 
                 0.94 
                 0.85 
                 0.89 
                 1.05 
               
               
                 1976 
                 0.77 
                 1.18 
                 1.06 
                 0.66 
                 0.90 
                 1.38 
               
               
                 1979 
                 0.87 
                 1.06 
                 0.95 
                 0.82 
                 0.90 
                 1.09 
               
               
                 1982 
                 0.86 
                 0.99 
                 0.76 
                 0.88 
                 0.77 
                 0.87 
               
               
                 1985 
                 0.74 
                 1.15 
                 1.06 
                 0.65 
                 0.92 
                 1.42 
               
               
                 2016 
                 0.90 
                 0.93 
                 0.92 
                 0.97 
                 0.99 
                 1.02 
               
               
                 2021 
                 0.92 
                 0.91 
                 0.88 
                 1.00 
                 0.97 
                 0.97 
               
               
                 2024 
                 0.86 
                 0.91 
                 0.85 
                 0.94 
                 0.93 
                 0.99 
               
               
                 2034 
                 0.84 
                 0.72 
                 0.73 
                 1.17 
                 1.01 
                 0.86 
                 Y 
               
               
                 2052 
                 0.77 
                 0.83 
                 0.71 
                 0.93 
                 0.85 
                 0.91 
                 Y 
               
               
                 2067 
                 0.80 
                 0.83 
                 0.77 
                 0.96 
                 0.92 
                 0.96 
                 Y 
               
               
                 2072 
                 0.76 
                 0.91 
                 0.74 
                 0.84 
                 0.81 
                 0.97 
                 y 
               
               
                 2105 
                 0.83 
                 0.56 
                 0.65 
                 1.49 
                 1.16 
                 0.78 
               
               
                 2106 
                 0.91 
                 0.61 
                 0.76 
                 1.50 
                 1.25 
                 0.83 
                 y 
               
               
                 2107 
                 0.88 
                 0.65 
                 0.75 
                 1.36 
                 1.17 
                 0.86 
               
               
                 2113 
                 0.89 
                 0.56 
                 0.71 
                 1.60 
                 1.28 
                 0.80 
               
               
                 2115 
                 0.88 
                 0.61 
                 0.68 
                 1.45 
                 1.12 
                 0.77 
               
               
                 2118 
                 0.86 
                 0.85 
                 0.94 
                 1.01 
                 1.11 
                 1.10 
               
               
                 2136 
                 0.49 
                 0.75 
                 0.39 
                 0.65 
                 0.51 
                 0.78 
               
               
                 2157 
                 0.89 
                 0.61 
                 0.72 
                 1.45 
                 1.18 
                 0.81 
               
               
                 2164 
                 0.80 
                 0.70 
                 0.68 
                 1.15 
                 0.97 
                 0.85 
                 Y 
               
               
                 2165 
                 0.60 
                 0.91 
                 0.64 
                 0.67 
                 0.70 
                 1.05 
               
               
                 2166 
                 0.96 
                 0.75 
                 0.84 
                 1.27 
                 1.11 
                 0.87 
               
               
                 2168 
                 0.91 
                 0.84 
                 0.99 
                 1.08 
                 1.18 
                 1.09 
               
               
                 2179 
                 0.88 
                 0.57 
                 0.92 
                 1.53 
                 1.60 
                 1.04 
               
               
                 2192 
                 0.73 
                 0.50 
                 0.69 
                 1.46 
                 1.38 
                 0.95 
               
               
                 2193 
                 0.81 
                 0.38 
                 0.71 
                 2.12 
                 1.87 
                 0.88 
                 y 
               
               
                 2194 
                 0.66 
                 0.76 
                 0.59 
                 0.87 
                 0.78 
                 0.90 
               
               
                 2199 
                 0.43 
                 0.82 
                 0.37 
                 0.53 
                 0.45 
                 0.85 
                 y 
               
               
                 2203 
                 0.60 
                 0.98 
                 0.64 
                 0.61 
                 0.65 
                 1.07 
               
               
                 2206 
                 0.61 
                 0.59 
                 0.52 
                 1.04 
                 0.87 
                 0.84 
               
               
                 2209 
                 0.60 
                 0.63 
                 0.53 
                 0.96 
                 0.85 
                 0.88 
                 y 
               
               
                 2211 
                 0.74 
                 0.61 
                 0.62 
                 1.22 
                 1.02 
                 0.84 
               
               
                 2217 
                 0.56 
                 0.91 
                 0.51 
                 0.61 
                 0.56 
                 0.92 
                 y 
               
               
                 2310 
                 0.88 
                 1.04 
                 0.90 
                 0.85 
                 0.86 
                 1.02 
               
               
                 2311 
                 0.84 
                 1.23 
                 1.01 
                 0.69 
                 0.83 
                 1.20 
               
               
                 2312 
                 0.77 
                 0.73 
                 0.67 
                 1.05 
                 0.91 
                 0.87 
                 Y 
               
               
                 2313 
                 0.87 
                 0.81 
                 0.75 
                 1.08 
                 0.93 
                 0.86 
               
               
                 2314 
                 0.82 
                 0.99 
                 0.88 
                 0.83 
                 0.89 
                 1.07 
               
               
                 2318 
                 0.84 
                 1.01 
                 0.81 
                 0.84 
                 0.81 
                 0.97 
               
               
                 2327 
                 0.80 
                 0.92 
                 0.82 
                 0.87 
                 0.89 
                 1.03 
               
               
                 2343 
                 0.77 
                 0.73 
                 0.65 
                 1.05 
                 0.90 
                 0.85 
                 Y 
               
               
                 2345 
                 0.79 
                 0.91 
                 0.70 
                 0.87 
                 0.77 
                 0.88 
                 Y 
               
               
                 2347 
                 0.76 
                 0.75 
                 0.63 
                 1.01 
                 0.84 
                 0.83 
                 Y 
               
               
                 2348 
                 0.89 
                 1.16 
                 0.97 
                 0.77 
                 0.84 
                 1.09 
               
               
                 2350 
                 0.84 
                 0.85 
                 0.85 
                 0.99 
                 1.00 
                 1.01 
               
               
                 2351 
                 0.64 
                 0.79 
                 0.68 
                 0.81 
                 0.86 
                 1.06 
                 y 
               
               
                 2356 
                 0.76 
                 0.66 
                 0.77 
                 1.14 
                 1.17 
                 1.02 
                 Y 
               
               
                 2357 
                 0.72 
                 0.91 
                 0.80 
                 0.78 
                 0.88 
                 1.12 
               
               
                 2360 
                 0.71 
                 0.94 
                 0.69 
                 0.76 
                 0.74 
                 0.97 
               
               
                 2361 
                 0.61 
                 1.00 
                 0.75 
                 0.61 
                 0.75 
                 1.24 
               
               
                 2364 
                 0.74 
                 0.95 
                 0.76 
                 0.77 
                 0.80 
                 1.03 
               
               
                 2371 
                 0.50 
                 1.02 
                 0.74 
                 0.49 
                 0.73 
                 1.49 
               
               
                 2374 
                 0.44 
                 1.03 
                 0.58 
                 0.43 
                 0.57 
                 1.34 
               
               
                 2375 
                 0.75 
                 0.80 
                 0.73 
                 0.94 
                 0.91 
                 0.98 
               
               
                 2376 
                 0.60 
                 0.74 
                 0.56 
                 0.81 
                 0.76 
                 0.94 
               
               
                 2379 
                 0.74 
                 0.81 
                 0.65 
                 0.91 
                 0.81 
                 0.89 
               
               
                 2381 
                 0.44 
                 0.81 
                 0.70 
                 0.54 
                 0.86 
                 1.59 
               
               
                 2383 
                 0.49 
                 0.99 
                 0.56 
                 0.49 
                 0.57 
                 1.15 
               
               
                 2394 
                 0.72 
                 0.88 
                 0.74 
                 0.82 
                 0.85 
                 1.04 
                 y 
               
               
                 2395 
                 0.58 
                 0.95 
                 0.86 
                 0.61 
                 0.90 
                 1.47 
                 Y 
               
               
                 2407 
                 0.81 
                 0.81 
                 0.90 
                 1.01 
                 1.11 
                 1.10 
               
               
                 2411 
                 0.81 
                 0.83 
                 0.79 
                 0.98 
                 0.96 
                 0.97 
               
               
                 2413 
                 0.63 
                 0.84 
                 0.72 
                 0.75 
                 0.86 
                 1.15 
                 Y 
               
               
                 2416 
                 1.03 
                 1.30 
                 1.16 
                 0.79 
                 0.90 
                 1.13 
               
               
                 2418 
                 0.65 
                 0.94 
                 0.88 
                 0.69 
                 0.93 
                 1.36 
                 Y 
               
               
                 2419 
                 0.78 
                 1.04 
                 0.76 
                 0.75 
                 0.73 
                 0.97 
               
               
                 2420 
                 0.78 
                 0.84 
                 0.76 
                 0.93 
                 0.91 
                 0.97 
                 y 
               
               
                 2422 
                 0.71 
                 0.96 
                 0.61 
                 0.74 
                 0.63 
                 0.85 
                 Y 
               
               
                 2423 
                 0.41 
                 0.62 
                 0.19 
                 0.66 
                 0.31 
                 0.47 
                 Y 
               
               
                 2426 
                 0.61 
                 0.87 
                 0.69 
                 0.70 
                 0.79 
                 1.13 
                 Y 
               
               
                 2429 
                 0.85 
                 0.91 
                 0.82 
                 0.93 
                 0.90 
                 0.97 
               
               
                 2431 
                 0.58 
                 0.85 
                 0.71 
                 0.68 
                 0.83 
                 1.22 
               
               
                 2432 
                 0.72 
                 0.96 
                 0.84 
                 0.74 
                 0.87 
                 1.17 
                 Y 
               
               
                 2442 
                 0.78 
                 0.93 
                 0.96 
                 0.84 
                 1.03 
                 1.23 
               
               
                 2443 
                 0.77 
                 0.80 
                 0.81 
                 0.95 
                 1.01 
                 1.06 
                 y 
               
               
                 2445 
                 0.77 
                 0.89 
                 0.78 
                 0.86 
                 0.88 
                 1.02 
               
               
                 2448 
                 0.95 
                 0.92 
                 0.61 
                 1.03 
                 0.66 
                 0.64 
                 y 
               
               
                 2449 
                 0.66 
                 0.72 
                 0.55 
                 0.91 
                 0.76 
                 0.84 
                 Y 
               
               
                 2474 
                 0.86 
                 0.84 
                 0.79 
                 1.02 
                 0.95 
                 0.93 
               
               
                 2480 
                 0.77 
                 0.83 
                 0.70 
                 0.92 
                 0.84 
                 0.91 
                 Y 
               
               
                 2481 
                 0.84 
                 0.79 
                 0.65 
                 1.06 
                 0.83 
                 0.78 
                 Y 
               
               
                 2488 
                 0.72 
                 0.83 
                 0.58 
                 0.87 
                 0.70 
                 0.80 
                 Y 
               
               
                 2491 
                 0.79 
                 0.72 
                 0.68 
                 1.09 
                 0.94 
                 0.86 
                 Y 
               
               
                 2493 
                 0.75 
                 0.72 
                 0.65 
                 1.05 
                 0.91 
                 0.87 
                 Y 
               
               
                 2498 
                 0.69 
                 0.58 
                 0.47 
                 1.19 
                 0.80 
                 0.68 
                 Y 
               
               
                 2499 
                 0.72 
                 0.71 
                 0.67 
                 1.02 
                 0.95 
                 0.93 
                 Y 
               
               
                 2513 
                 0.78 
                 0.90 
                 0.77 
                 0.87 
                 0.86 
                 0.99 
                 Y 
               
               
                 2514 
                 0.73 
                 0.63 
                 0.56 
                 1.16 
                 0.88 
                 0.76 
                 Y 
               
               
                 2517 
                 0.80 
                 0.84 
                 0.71 
                 0.95 
                 0.85 
                 0.89 
                 Y 
               
               
                 2518 
                 0.70 
                 0.75 
                 0.72 
                 0.93 
                 0.96 
                 1.03 
                 Y 
               
               
                 2520 
                 0.87 
                 0.94 
                 0.89 
                 0.92 
                 0.95 
                 1.03 
               
               
                 2522 
                 0.95 
                 1.08 
                 1.11 
                 0.88 
                 1.02 
                 1.16 
               
               
                 2523 
                 0.88 
                 0.86 
                 0.82 
                 1.01 
                 0.95 
                 0.93 
               
               
                 2525 
                 0.87 
                 0.88 
                 0.95 
                 0.99 
                 1.08 
                 1.09 
               
               
                 2543 
                 0.90 
                 0.94 
                 0.94 
                 0.95 
                 1.00 
                 1.05 
               
               
                 2547 
                 0.75 
                 0.90 
                 0.99 
                 0.83 
                 1.10 
                 1.33 
               
               
                 2549 
                 0.98 
                 0.90 
                 1.22 
                 1.08 
                 1.35 
                 1.25 
               
               
                 2561 
                 0.81 
                 0.82 
                 0.82 
                 0.98 
                 0.99 
                 1.01 
                 y 
               
               
                 2563 
                 0.84 
                 0.67 
                 0.70 
                 1.24 
                 1.03 
                 0.83 
                 Y 
               
               
                 2564 
                 0.55 
                 0.40 
                 0.39 
                 1.38 
                 0.98 
                 0.71 
                 Y 
               
               
                 2565 
                 0.98 
                 0.93 
                 0.99 
                 1.05 
                 1.06 
                 1.01 
               
               
                 2566 
                 0.86 
                 0.84 
                 0.88 
                 1.03 
                 1.05 
                 1.02 
               
               
                 2567 
                 0.96 
                 0.84 
                 0.84 
                 1.15 
                 1.01 
                 0.87 
                 y 
               
               
                 2568 
                 0.80 
                 0.64 
                 0.60 
                 1.25 
                 0.95 
                 0.76 
                 Y 
               
               
                 2569 
                 0.67 
                 0.53 
                 0.71 
                 1.26 
                 1.33 
                 1.06 
                 y 
               
               
                 2570 
                 0.80 
                 0.64 
                 0.73 
                 1.25 
                 1.15 
                 0.92 
                 Y 
               
               
                 2575 
                 0.96 
                 0.87 
                 0.98 
                 1.10 
                 1.12 
                 1.02 
               
               
                 2577 
                 0.96 
                 0.75 
                 0.87 
                 1.28 
                 1.15 
                 0.90 
               
               
                 2579 
                 0.88 
                 0.80 
                 0.91 
                 1.10 
                 1.14 
                 1.04 
               
               
                 2580 
                 0.77 
                 0.55 
                 0.62 
                 1.39 
                 1.13 
                 0.81 
                 Y 
               
               
                 2581 
                 0.91 
                 0.75 
                 0.82 
                 1.21 
                 1.09 
                 0.90 
               
               
                 2583 
                 0.84 
                 0.68 
                 0.69 
                 1.24 
                 1.02 
                 0.83 
                 Y 
               
               
                 2588 
                 0.92 
                 0.84 
                 0.88 
                 1.09 
                 1.04 
                 0.95 
               
               
                 2591 
                 0.91 
                 0.75 
                 0.70 
                 1.21 
                 0.93 
                 0.77 
                 Y 
               
               
                 2592 
                 0.80 
                 0.81 
                 0.94 
                 0.98 
                 1.16 
                 1.18 
                 Y 
               
               
                 2594 
                 0.88 
                 0.84 
                 0.82 
                 1.05 
                 0.98 
                 0.94 
               
               
                 2610 
                 0.73 
                 0.52 
                 0.57 
                 1.40 
                 1.11 
                 0.79 
                 Y 
               
               
                 2624 
                 0.91 
                 0.78 
                 0.73 
                 1.17 
                 0.94 
                 0.80 
                 Y 
               
               
                 2625 
                 0.86 
                 0.78 
                 0.72 
                 1.11 
                 0.93 
                 0.84 
                 Y 
               
               
                 2649 
                 1.10 
                 0.66 
                 0.97 
                 1.67 
                 1.46 
                 0.87 
                 Y 
               
               
                 2652 
                 0.80 
                 0.65 
                 0.57 
                 1.22 
                 0.87 
                 0.71 
                 Y 
               
               
                 2669 
                 1.20 
                 0.11 
                 0.74 
                 10.96 
                 6.75 
                 0.62 
               
               
                 3453 
                 0.51 
                 0.57 
                 0.43 
                 0.90 
                 0.76 
                 0.85 
                 Y 
               
               
                 3454 
                 0.90 
                 0.90 
                 0.82 
                 1.00 
                 0.91 
                 0.91 
                 Y 
               
               
                 3455 
                 0.81 
                 0.80 
                 0.71 
                 1.01 
                 0.89 
                 0.88 
                 y 
               
               
                 3456 
                 0.56 
                 0.45 
                 0.31 
                 1.24 
                 0.69 
                 0.56 
                 Y 
               
               
                 3458 
                 0.38 
                 0.67 
                 0.28 
                 0.57 
                 0.42 
                 0.74 
                 Y 
               
               
                 3461 
                 0.83 
                 0.69 
                 0.73 
                 1.20 
                 1.05 
                 0.88 
                 Y 
               
               
                 3462 
                 0.94 
                 0.91 
                 0.79 
                 1.03 
                 0.87 
                 0.84 
                 Y 
               
               
                 3464 
                 0.84 
                 0.46 
                 0.69 
                 1.81 
                 1.49 
                 0.83 
                 Y 
               
               
                 3466 
                 0.72 
                 0.60 
                 0.57 
                 1.19 
                 0.95 
                 0.80 
                 Y 
               
               
                 3471 
                 1.03 
                 0.77 
                 1.07 
                 1.35 
                 1.40 
                 1.04 
                 y 
               
               
                 3472 
                 1.01 
                 0.98 
                 1.07 
                 1.03 
                 1.10 
                 1.07 
               
               
                 3473 
                 1.16 
                 0.78 
                 0.92 
                 1.49 
                 1.18 
                 0.79 
                 y 
               
               
                 3474 
                 1.15 
                 0.83 
                 1.05 
                 1.40 
                 1.27 
                 0.91 
                 Y 
               
               
                 3478 
                 0.73 
                 0.75 
                 0.69 
                 0.97 
                 0.91 
                 0.94 
                 Y 
               
               
                 3479 
                 0.85 
                 0.86 
                 1.06 
                 0.98 
                 1.23 
                 1.25 
               
               
                 3480 
                 0.89 
                 1.01 
                 0.98 
                 0.88 
                 0.97 
                 1.10 
               
               
                 3485 
                 0.70 
                 0.61 
                 0.61 
                 1.16 
                 1.00 
                 0.87 
                 Y 
               
               
                 3495 
                 0.87 
                 0.78 
                 0.77 
                 1.12 
                 0.99 
                 0.88 
                 Y 
               
               
                 3498 
                 1.05 
                 1.18 
                 1.17 
                 0.89 
                 1.00 
                 1.12 
               
               
                 3505 
                 0.65 
                 0.73 
                 0.53 
                 0.89 
                 0.72 
                 0.81 
                 Y 
               
               
                 3507 
                 0.83 
                 0.73 
                 0.76 
                 1.13 
                 1.04 
                 0.92 
                 Y 
               
               
                 3508 
                 0.83 
                 0.90 
                 0.82 
                 0.92 
                 0.91 
                 0.98 
                 Y 
               
               
                 3513 
                 0.83 
                 1.05 
                 0.89 
                 0.79 
                 0.84 
                 1.07 
               
               
                 3514 
                 0.73 
                 1.07 
                 0.82 
                 0.69 
                 0.76 
                 1.11 
               
               
                 3516 
                 0.74 
                 0.69 
                 0.68 
                 1.07 
                 0.98 
                 0.91 
                 Y 
               
               
                 3522 
                 0.76 
                 0.58 
                 0.68 
                 1.32 
                 1.17 
                 0.89 
                 Y 
               
               
                 3528 
                 0.84 
                 0.74 
                 0.64 
                 1.15 
                 0.87 
                 0.76 
                 y 
               
               
                 3530 
                 0.91 
                 0.94 
                 0.88 
                 0.98 
                 0.94 
                 0.96 
               
               
                 3533 
                 1.11 
                 1.07 
                 1.58 
                 1.04 
                 1.48 
                 1.42 
                 Y 
               
               
                 3534 
                 0.97 
                 0.89 
                 1.88 
                 1.08 
                 2.10 
                 1.94 
                 Y 
               
               
                 3535 
                 0.99 
                 0.81 
                 0.94 
                 1.22 
                 1.15 
                 0.95 
               
               
                 3537 
                 0.81 
                 0.77 
                 0.81 
                 1.05 
                 1.05 
                 1.00 
                 y 
               
               
                 3541 
                 0.58 
                 0.81 
                 0.55 
                 0.72 
                 0.68 
                 0.95 
               
               
                 3542 
                 0.97 
                 0.99 
                 1.11 
                 0.98 
                 1.12 
                 1.14 
               
               
                 3547 
                 0.82 
                 0.86 
                 0.74 
                 0.95 
                 0.86 
                 0.90 
                 Y 
               
               
                 3548 
                 0.68 
                 0.82 
                 0.61 
                 0.82 
                 0.74 
                 0.90 
                 Y 
               
               
                 3549 
                 0.97 
                 0.80 
                 0.85 
                 1.21 
                 1.06 
                 0.88 
                 Y 
               
               
                 3550 
                 0.91 
                 0.73 
                 0.71 
                 1.26 
                 0.98 
                 0.78 
                 Y 
               
               
                 3552 
                 1.14 
                 0.91 
                 0.73 
                 1.25 
                 0.80 
                 0.64 
                 Y 
               
               
                 3563 
                 1.07 
                 0.78 
                 0.86 
                 1.37 
                 1.11 
                 0.81 
               
               
                 3565 
                 0.74 
                 0.63 
                 0.76 
                 1.18 
                 1.20 
                 1.02 
               
               
                 3566 
                 0.79 
                 0.64 
                 0.62 
                 1.23 
                 0.98 
                 0.79 
                 Y 
               
               
                 3567 
                 0.83 
                 0.74 
                 0.75 
                 1.13 
                 1.02 
                 0.90 
                 Y 
               
               
                 3568 
                 0.84 
                 0.79 
                 1.03 
                 1.06 
                 1.31 
                 1.23 
                 Y 
               
               
                 3572 
                 0.58 
                 0.81 
                 0.65 
                 0.72 
                 0.81 
                 1.12 
               
               
                 3573 
                 0.90 
                 0.98 
                 1.06 
                 0.92 
                 1.09 
                 1.18 
               
               
                 3576 
                 0.64 
                 0.65 
                 0.63 
                 0.99 
                 0.97 
                 0.98 
                 Y 
               
               
                 3577 
                 0.77 
                 0.84 
                 0.73 
                 0.92 
                 0.87 
                 0.95 
                 Y 
               
               
                 3578 
                 0.86 
                 0.90 
                 1.01 
                 0.96 
                 1.12 
                 1.17 
               
               
                 3579 
                 0.54 
                 0.50 
                 0.45 
                 1.07 
                 0.90 
                 0.84 
                 Y 
               
               
                 3580 
                 0.82 
                 0.72 
                 0.75 
                 1.14 
                 1.04 
                 0.92 
                 y 
               
               
                 3585 
                 0.76 
                 0.93 
                 0.89 
                 0.81 
                 0.95 
                 1.17 
               
               
                 3587 
                 0.59 
                 0.68 
                 0.54 
                 0.86 
                 0.80 
                 0.93 
                 Y 
               
               
                 3588 
                 0.80 
                 0.73 
                 0.72 
                 1.10 
                 0.98 
                 0.89 
                 Y 
               
               
                 3589 
                 0.46 
                 0.35 
                 0.36 
                 1.31 
                 1.04 
                 0.79 
                 Y 
               
               
                 3598 
                 0.72 
                 0.79 
                 0.64 
                 0.91 
                 0.82 
                 0.89 
                 Y 
               
               
                 3599 
                 1.09 
                 0.81 
                 0.96 
                 1.35 
                 1.18 
                 0.88 
               
               
                 3602 
                 0.68 
                 0.91 
                 0.80 
                 0.74 
                 0.87 
                 1.18 
               
               
                 3603 
                 0.67 
                 0.74 
                 0.75 
                 0.91 
                 1.02 
                 1.12 
                 Y 
               
               
                 3607 
                 0.49 
                 1.11 
                 0.44 
                 0.44 
                 0.40 
                 0.90 
                 Y 
               
               
                 3608 
                 0.56 
                 1.00 
                 0.61 
                 0.56 
                 0.61 
                 1.08 
                 Y 
               
               
                 3624 
                 0.84 
                 0.85 
                 0.84 
                 0.99 
                 0.99 
                 1.00 
                 Y 
               
               
                 3627 
                 0.88 
                 0.70 
                 0.72 
                 1.26 
                 1.03 
                 0.82 
               
               
                 3628 
                 0.85 
                 0.85 
                 0.88 
                 1.00 
                 1.04 
                 1.04 
               
               
                 3636 
                 1.58 
                 1.35 
                 1.41 
                 1.17 
                 1.04 
                 0.89 
                 Y 
               
               
                 3641 
                 0.90 
                 0.58 
                 0.55 
                 1.55 
                 0.95 
                 0.61 
                 Y 
               
               
                 3643 
                 1.59 
                 1.08 
                 0.93 
                 1.48 
                 0.86 
                 0.58 
                 Y 
               
               
                 3644 
                 1.65 
                 1.04 
                 0.97 
                 1.58 
                 0.94 
                 0.59 
                 Y 
               
               
                 3648 
                 0.89 
                 0.95 
                 0.88 
                 0.94 
                 0.92 
                 0.98 
               
               
                 3649 
                 0.87 
                 0.77 
                 0.77 
                 1.13 
                 1.00 
                 0.88 
                 Y 
               
               
                 3650 
                 0.77 
                 0.85 
                 0.71 
                 0.91 
                 0.83 
                 0.92 
               
               
                 3651 
                 0.98 
                 0.80 
                 0.72 
                 1.22 
                 0.90 
                 0.74 
                 Y 
               
               
                 3653 
                 0.65 
                 0.97 
                 0.69 
                 0.68 
                 0.71 
                 1.05 
                 Y 
               
               
                 3654 
                 0.84 
                 0.82 
                 0.65 
                 1.03 
                 0.79 
                 0.77 
                 Y 
               
               
                 3656 
                 0.81 
                 0.94 
                 0.84 
                 0.87 
                 0.89 
                 1.03 
               
               
                 3658 
                 0.65 
                 0.78 
                 0.57 
                 0.84 
                 0.74 
                 0.88 
                 y 
               
               
                 3662 
                 0.67 
                 1.07 
                 0.60 
                 0.63 
                 0.57 
                 0.91 
               
               
                 3663 
                 0.85 
                 0.24 
                 0.66 
                 3.56 
                 2.77 
                 0.78 
               
               
                 3664 
                 1.08 
                 0.51 
                 1.20 
                 2.10 
                 2.35 
                 1.12 
                 y 
               
               
                 3667 
                 1.03 
                 0.61 
                 0.99 
                 1.68 
                 1.62 
                 0.96 
               
               
                 3668 
                 0.80 
                 0.74 
                 0.78 
                 1.07 
                 1.05 
                 0.98 
                 Y 
               
               
                 3670 
                 0.61 
                 1.31 
                 0.90 
                 0.46 
                 0.69 
                 1.49 
               
               
                 3694 
                 0.81 
                 0.37 
                 0.44 
                 2.17 
                 1.17 
                 0.54 
                 Y 
               
               
                 3698 
                 1.12 
                 0.92 
                 0.80 
                 1.22 
                 0.87 
                 0.71 
               
               
                 3714 
                 0.42 
                 0.89 
                 0.41 
                 0.47 
                 0.46 
                 0.97 
                 Y 
               
               
                 3715 
                 0.53 
                 0.78 
                 0.66 
                 0.68 
                 0.84 
                 1.25 
                 y 
               
               
                 3718 
                 0.66 
                 0.92 
                 0.71 
                 0.72 
                 0.78 
                 1.08 
               
               
                 3727 
                 0.64 
                 0.67 
                 0.56 
                 0.96 
                 0.84 
                 0.88 
                 Y 
               
               
                 3728 
                 0.89 
                 0.84 
                 0.83 
                 1.06 
                 0.99 
                 0.93 
               
               
                 3751 
                 0.81 
                 0.95 
                 0.58 
                 0.85 
                 0.61 
                 0.72 
                 Y 
               
               
                 3754 
                 0.89 
                 0.83 
                 0.72 
                 1.07 
                 0.87 
                 0.81 
                 Y 
               
               
                 3757 
                 0.42 
                 0.24 
                 0.24 
                 1.72 
                 1.00 
                 0.58 
                 Y 
               
               
                 3771 
                 0.92 
                 0.96 
                 1.12 
                 0.96 
                 1.17 
                 1.22 
               
               
                 3978 
                 0.84 
                 0.59 
                 0.81 
                 1.43 
                 1.37 
                 0.96 
               
               
                 4000 
                 1.01 
                 0.67 
                 1.24 
                 1.52 
                 1.86 
                 1.22 
                 y 
               
               
                 4079 
                 0.98 
                 1.19 
                 0.79 
                 0.83 
                 0.66 
                 0.80 
                 Y 
               
               
                 4108 
                 0.72 
                 0.38 
                 0.46 
                 1.91 
                 1.24 
                 0.65 
                 Y 
               
               
                 4131 
                 0.88 
                 0.94 
                 1.00 
                 0.93 
                 1.07 
                 1.14 
               
               
                 4144 
                 0.95 
                 0.75 
                 0.84 
                 1.26 
                 1.12 
                 0.88 
                 y 
               
               
                 4221 
                 0.77 
                 0.44 
                 0.57 
                 1.75 
                 1.28 
                 0.73 
                 Y 
               
               
                 4246 
                 1.45 
                 0.62 
                 0.98 
                 2.32 
                 1.57 
                 0.68 
                 Y 
               
               
                 4274 
                 0.98 
                 0.46 
                 0.40 
                 2.14 
                 0.87 
                 0.41 
                 Y 
               
               
                 4363 
                 1.03 
                 0.56 
                 0.78 
                 1.84 
                 1.39 
                 0.76 
               
               
                 4756 
                 0.92 
                 0.71 
                 0.74 
                 1.29 
                 1.04 
                 0.80 
               
               
                 4832 
                 0.95 
                 1.06 
                 0.96 
                 0.90 
                 0.91 
                 1.02 
               
               
                 4835 
                 0.95 
                 0.47 
                 0.58 
                 2.01 
                 1.22 
                 0.61 
                 Y 
               
               
                 4899 
                 1.68 
                 0.81 
                 0.62 
                 2.09 
                 0.77 
                 0.37 
                 Y 
               
               
                 4926 
                 0.91 
                 0.91 
                 18.88 
                 1.00 
                 20.85 
                 20.85 
                 Y 
               
               
                 4930 
                 2.31 
                 1.16 
                 1.25 
                 1.99 
                 1.07 
                 0.54 
                 Y 
               
               
                 4971 
                 0.47 
                 1.08 
                 0.56 
                 0.44 
                 0.52 
                 1.19 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 4D 
               
             
            
               
                   
                   
               
               
                   
                 Sp/SPF 
                 ABX/SPF 
                 GF/SPF 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 PSO 
                 p-value 
                 q-value 
                 p-value 
                 q-value 
                 p-value 
                 q-value 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 1 
                 0.0548 
                 0.0477 
                 0.0416 
                 0.0281 
                 0.5657 
                 0.2280 
               
               
                 2 
                 0.5443 
                 0.2032 
                 0.9539 
                 0.2475 
                 0.1960 
                 0.1011 
               
               
                 5 
                 0.0091 
                 0.0213 
                 0.0012 
                 0.0040 
                 0.0690 
                 0.0459 
               
               
                 6 
                 0.0331 
                 0.0377 
                 0.0003 
                 0.0022 
                 0.0297 
                 0.0247 
               
               
                 9 
                 0.2191 
                 0.1076 
                 0.4977 
                 0.1556 
                 0.6786 
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                 10 
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                 14 
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                 16 
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                 17 
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                 18 
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                 21 
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                 28 
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                 30 
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                 34 
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                 35 
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                 38 
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                 39 
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                 40 
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                 41 
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                 42 
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                 43 
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                 44 
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                 45 
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                 47 
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                 50 
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                 51 
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                 52 
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                 53 
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                 54 
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                 55 
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                 56 
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                 59 
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                 65 
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                 66 
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                 67 
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                 68 
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                 74 
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                 75 
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                 76 
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                 77 
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                 80 
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                 82 
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                 83 
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                 84 
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                 92 
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                 93 
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                 99 
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                 100 
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                 101 
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                 102 
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                 103 
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                 105 
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                 107 
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                 113 
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                 114 
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                 117 
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                 119 
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                 120 
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                 121 
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                 122 
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                 126 
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                 137 
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                 138 
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                 150 
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                 154 
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                 180 
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                 181 
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                 191 
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                 210 
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                 217 
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                 221 
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                 227 
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                 241 
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                 254 
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                 261 
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                 263 
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                 265 
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                 273 
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                 280 
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                 296 
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                 299 
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                 300 
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                 301 
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                 303 
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                 306 
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                 311 
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                 312 
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                 318 
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                 321 
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                 323 
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                 326 
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                 328 
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                 332 
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                 333 
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                 334 
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                 337 
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                 342 
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                 343 
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                 349 
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                 351 
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                 353 
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                 362 
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                 363 
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                 364 
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                 365 
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                 367 
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                 369 
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                 371 
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                 372 
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                 373 
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                 375 
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                 379 
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                 380 
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                 381 
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                 382 
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                 383 
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                 386 
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                 387 
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                 392 
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                 397 
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                 399 
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                 405 
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                 410 
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                 411 
                 0.0330 
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                 412 
                 0.1453 
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                 418 
                 0.2303 
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                 421 
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                 426 
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                 429 
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                 430 
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                 436 
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                 438 
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                 439 
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                 442 
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                 443 
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                 445 
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                 446 
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                 447 
                 0.2880 
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                 451 
                 0.0141 
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                 454 
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                 456 
                 0.0039 
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                 459 
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                 460 
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                 461 
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                 465 
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                 467 
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                 468 
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                 469 
                 0.0037 
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                 471 
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                 472 
                 0.1667 
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                 473 
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                 474 
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                 475 
                 0.0411 
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                 476 
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                 0.1640 
               
               
                 477 
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                 478 
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                 479 
                 0.3103 
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                 480 
                 0.3659 
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                 756 
                 0.3654 
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                 929 
                 0.5433 
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                 955 
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                 958 
                 0.3663 
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                 959 
                 0.1689 
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                 965 
                 0.2470 
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                 0.0969 
               
               
                 967 
                 0.0286 
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                 972 
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                 973 
                 0.8061 
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                 974 
                 0.0447 
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                 0.1791 
                 0.0949 
               
               
                 975 
                 0.0005 
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                 0.0010 
                 0.0032 
               
               
                 978 
                 0.9885 
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                 0.2643 
               
               
                 981 
                 0.0542 
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                 0.2267 
                 0.0893 
                 0.6479 
                 0.2526 
               
               
                 982 
                 0.4432 
                 0.1744 
                 0.0189 
                 0.0171 
                 0.4315 
                 0.1814 
               
               
                 983 
                 0.9472 
                 0.2949 
                 0.8998 
                 0.2365 
                 0.6677 
                 0.2567 
               
               
                 984 
                 0.3448 
                 0.1469 
                 0.3587 
                 0.1256 
                 0.4059 
                 0.1733 
               
               
                 986 
                 0.0624 
                 0.0518 
                 0.0033 
                 0.0064 
                 0.0320 
                 0.0262 
               
               
                 993 
                 0.0148 
                 0.0272 
                 0.4881 
                 0.1535 
                 0.2286 
                 0.1140 
               
               
                 994 
                 0.0012 
                 0.0093 
                 0.0003 
                 0.0021 
                 0.0457 
                 0.0339 
               
               
                 995 
                 0.0638 
                 0.0521 
                 0.1599 
                 0.0694 
                 0.2922 
                 0.1376 
               
               
                 997 
                 0.0215 
                 0.0318 
                 0.0158 
                 0.0152 
                 0.0053 
                 0.0081 
               
               
                 1018 
                 0.0900 
                 0.0627 
                 0.0000 
                 0.0001 
                 0.0047 
                 0.0075 
               
               
                 1020 
                 0.0287 
                 0.0345 
                 0.0035 
                 0.0064 
                 0.0170 
                 0.0174 
               
               
                 1023 
                 0.0217 
                 0.0319 
                 0.0002 
                 0.0018 
                 0.0049 
                 0.0076 
               
               
                 1024 
                 0.0027 
                 0.0145 
                 0.0472 
                 0.0305 
                 0.0085 
                 0.0109 
               
               
                 1028 
                 0.1334 
                 0.0791 
                 0.0128 
                 0.0134 
                 0.0090 
                 0.0111 
               
               
                 1030 
                 0.0753 
                 0.0566 
                 0.0030 
                 0.0060 
                 0.0086 
                 0.0109 
               
               
                 1033 
                 0.1458 
                 0.0850 
                 0.0289 
                 0.0222 
                 0.1117 
                 0.0658 
               
               
                 1073 
                 0.4055 
                 0.1633 
                 0.0188 
                 0.0171 
                 0.9752 
                 0.3338 
               
               
                 1078 
                 0.0016 
                 0.0108 
                 0.0001 
                 0.0005 
                 0.0001 
                 0.0011 
               
               
                 1079 
                 0.0262 
                 0.0342 
                 0.0095 
                 0.0111 
                 0.2445 
                 0.1201 
               
               
                 1080 
                 0.2055 
                 0.1030 
                 0.0061 
                 0.0083 
                 0.1997 
                 0.1020 
               
               
                 1090 
                 0.1167 
                 0.0732 
                 0.0096 
                 0.0111 
                 0.1746 
                 0.0941 
               
               
                 1099 
                 0.0249 
                 0.0338 
                 0.0150 
                 0.0149 
                 0.0128 
                 0.0148 
               
               
                 1104 
                 0.1581 
                 0.0910 
                 0.0287 
                 0.0222 
                 0.1761 
                 0.0942 
               
               
                 1108 
                 0.0419 
                 0.0418 
                 0.0133 
                 0.0134 
                 0.1971 
                 0.1012 
               
               
                 1109 
                 0.6916 
                 0.2378 
                 0.0258 
                 0.0213 
                 0.0405 
                 0.0310 
               
               
                 1111 
                 0.0517 
                 0.0465 
                 0.0038 
                 0.0065 
                 0.1108 
                 0.0654 
               
               
                 1115 
                 0.0624 
                 0.0518 
                 0.0026 
                 0.0055 
                 0.0142 
                 0.0156 
               
               
                 1116 
                 0.0131 
                 0.0257 
                 0.0056 
                 0.0078 
                 0.0259 
                 0.0229 
               
               
                 1123 
                 0.4137 
                 0.1653 
                 0.0221 
                 0.0187 
                 0.3392 
                 0.1526 
               
               
                 1127 
                 0.0211 
                 0.0316 
                 0.0045 
                 0.0069 
                 0.0153 
                 0.0163 
               
               
                 1131 
                 0.0093 
                 0.0213 
                 0.0160 
                 0.0152 
                 0.0518 
                 0.0369 
               
               
                 1132 
                 0.1700 
                 0.0926 
                 0.6435 
                 0.1878 
                 0.0936 
                 0.0576 
               
               
                 1138 
                 0.0251 
                 0.0338 
                 0.0104 
                 0.0118 
                 0.0017 
                 0.0038 
               
               
                 1149 
                 0.0057 
                 0.0192 
                 0.0023 
                 0.0053 
                 0.0058 
                 0.0086 
               
               
                 1150 
                 0.0137 
                 0.0262 
                 0.0079 
                 0.0096 
                 0.0192 
                 0.0188 
               
               
                 1152 
                 0.0663 
                 0.0522 
                 0.0569 
                 0.0340 
                 0.0157 
                 0.0167 
               
               
                 1157 
                 0.9363 
                 0.2935 
                 0.6088 
                 0.1806 
                 0.6641 
                 0.2558 
               
               
                 1163 
                 0.3487 
                 0.1475 
                 0.4639 
                 0.1495 
                 0.1786 
                 0.0949 
               
               
                 1165 
                 0.0005 
                 0.0056 
                 0.0114 
                 0.0126 
                 0.0042 
                 0.0069 
               
               
                 1166 
                 0.7412 
                 0.2482 
                 0.4717 
                 0.1513 
                 0.1773 
                 0.0946 
               
               
                 1167 
                 0.0315 
                 0.0366 
                 0.0193 
                 0.0172 
                 0.0247 
                 0.0224 
               
               
                 1169 
                 0.0391 
                 0.0401 
                 0.0016 
                 0.0046 
                 0.0007 
                 0.0024 
               
               
                 1179 
                 0.0346 
                 0.0379 
                 0.0080 
                 0.0096 
                 0.0489 
                 0.0355 
               
               
                 1181 
                 0.5308 
                 0.1999 
                 0.4388 
                 0.1446 
                 0.5643 
                 0.2280 
               
               
                 1183 
                 0.3341 
                 0.1438 
                 0.2221 
                 0.0884 
                 0.0003 
                 0.0014 
               
               
                 1201 
                 0.6309 
                 0.2222 
                 0.7208 
                 0.2018 
                 0.8625 
                 0.3088 
               
               
                 1203 
                 0.1969 
                 0.1019 
                 0.6710 
                 0.1942 
                 0.8455 
                 0.3061 
               
               
                 1204 
                 0.5120 
                 0.1952 
                 0.1269 
                 0.0577 
                 0.1178 
                 0.0681 
               
               
                 1205 
                 0.3455 
                 0.1469 
                 0.6358 
                 0.1859 
                 0.3340 
                 0.1517 
               
               
                 1217 
                 0.0487 
                 0.0447 
                 0.5537 
                 0.1687 
                 0.0778 
                 0.0511 
               
               
                 1218 
                 0.0081 
                 0.0209 
                 0.2226 
                 0.0884 
                 0.0021 
                 0.0044 
               
               
                 1223 
                 0.0920 
                 0.0633 
                 0.5789 
                 0.1745 
                 0.2451 
                 0.1201 
               
               
                 1225 
                 0.0182 
                 0.0297 
                 0.4807 
                 0.1520 
                 0.0185 
                 0.0184 
               
               
                 1236 
                 0.0501 
                 0.0455 
                 0.6842 
                 0.1969 
                 0.3370 
                 0.1526 
               
               
                 1239 
                 0.0940 
                 0.0641 
                 0.2318 
                 0.0908 
                 0.0870 
                 0.0549 
               
               
                 1244 
                 0.1143 
                 0.0722 
                 0.9588 
                 0.2475 
                 0.3050 
                 0.1415 
               
               
                 1247 
                 0.0625 
                 0.0518 
                 0.2825 
                 0.1053 
                 0.0204 
                 0.0196 
               
               
                 1253 
                 0.0042 
                 0.0169 
                 0.1081 
                 0.0511 
                 0.0397 
                 0.0307 
               
               
                 1258 
                 0.0044 
                 0.0169 
                 0.9563 
                 0.2475 
                 0.0011 
                 0.0032 
               
               
                 1259 
                 0.0197 
                 0.0311 
                 0.7007 
                 0.1994 
                 0.0100 
                 0.0121 
               
               
                 1260 
                 0.0178 
                 0.0293 
                 0.3749 
                 0.1300 
                 0.0074 
                 0.0101 
               
               
                 1264 
                 0.1640 
                 0.0923 
                 0.7715 
                 0.2128 
                 0.0881 
                 0.0552 
               
               
                 1265 
                 0.0063 
                 0.0199 
                 0.4549 
                 0.1476 
                 0.0232 
                 0.0215 
               
               
                 1267 
                 0.1873 
                 0.0980 
                 0.7023 
                 0.1994 
                 0.0899 
                 0.0560 
               
               
                 1269 
                 0.0071 
                 0.0206 
                 0.5167 
                 0.1594 
                 0.0168 
                 0.0173 
               
               
                 1270 
                 0.0212 
                 0.0317 
                 0.4066 
                 0.1371 
                 0.0149 
                 0.0161 
               
               
                 1271 
                 0.2503 
                 0.1176 
                 0.7887 
                 0.2163 
                 0.1964 
                 0.1011 
               
               
                 1272 
                 0.0850 
                 0.0610 
                 0.4064 
                 0.1371 
                 0.0909 
                 0.0564 
               
               
                 1273 
                 0.0286 
                 0.0345 
                 0.2812 
                 0.1053 
                 0.1121 
                 0.0658 
               
               
                 1274 
                 0.0260 
                 0.0342 
                 0.4067 
                 0.1371 
                 0.0465 
                 0.0343 
               
               
                 1276 
                 0.0764 
                 0.0567 
                 0.9658 
                 0.2488 
                 0.0825 
                 0.0532 
               
               
                 1277 
                 0.0949 
                 0.0642 
                 0.5427 
                 0.1663 
                 0.1451 
                 0.0800 
               
               
                 1351 
                 0.7712 
                 0.2561 
                 0.0131 
                 0.0134 
                 0.1758 
                 0.0942 
               
               
                 1355 
                 0.0084 
                 0.0209 
                 0.0049 
                 0.0071 
                 0.0128 
                 0.0148 
               
               
                 1359 
                 0.0699 
                 0.0537 
                 0.0477 
                 0.0305 
                 0.0236 
                 0.0218 
               
               
                 1360 
                 0.3241 
                 0.1413 
                 0.2133 
                 0.0861 
                 0.9511 
                 0.3284 
               
               
                 1363 
                 0.2205 
                 0.1080 
                 0.2480 
                 0.0954 
                 0.7531 
                 0.2828 
               
               
                 1372 
                 0.1691 
                 0.0924 
                 0.6654 
                 0.1930 
                 0.8791 
                 0.3125 
               
               
                 1430 
                 0.2336 
                 0.1110 
                 0.1155 
                 0.0531 
                 0.7501 
                 0.2822 
               
               
                 1446 
                 0.3972 
                 0.1611 
                 0.3729 
                 0.1296 
                 0.1014 
                 0.0608 
               
               
                 1449 
                 0.4257 
                 0.1687 
                 0.1443 
                 0.0635 
                 0.7732 
                 0.2865 
               
               
                 1452 
                 0.6222 
                 0.2205 
                 0.0018 
                 0.0050 
                 0.2910 
                 0.1376 
               
               
                 1480 
                 0.2975 
                 0.1322 
                 0.0096 
                 0.0111 
                 0.8213 
                 0.2991 
               
               
                 1482 
                 0.1755 
                 0.0947 
                 0.2191 
                 0.0877 
                 0.9634 
                 0.3309 
               
               
                 1483 
                 0.0839 
                 0.0607 
                 0.2273 
                 0.0893 
                 0.2445 
                 0.1201 
               
               
                 1485 
                 0.0564 
                 0.0487 
                 0.9090 
                 0.2379 
                 0.0029 
                 0.0055 
               
               
                 1487 
                 0.4882 
                 0.1896 
                 0.1128 
                 0.0524 
                 0.3045 
                 0.1415 
               
               
                 1488 
                 0.0472 
                 0.0435 
                 0.9923 
                 0.2543 
                 0.0141 
                 0.0156 
               
               
                 1495 
                 0.2233 
                 0.1081 
                 0.2683 
                 0.1018 
                 0.0081 
                 0.0108 
               
               
                 1496 
                 0.1398 
                 0.0823 
                 0.0738 
                 0.0393 
                 0.1609 
                 0.0875 
               
               
                 1498 
                 0.9880 
                 0.3040 
                 0.0047 
                 0.0069 
                 0.3986 
                 0.1714 
               
               
                 1499 
                 0.1241 
                 0.0764 
                 0.0420 
                 0.0281 
                 0.0286 
                 0.0241 
               
               
                 1500 
                 0.2032 
                 0.1024 
                 0.0006 
                 0.0028 
                 0.0143 
                 0.0156 
               
               
                 1501 
                 0.2558 
                 0.1190 
                 0.0716 
                 0.0387 
                 0.0031 
                 0.0056 
               
               
                 1503 
                 0.0172 
                 0.0288 
                 0.3248 
                 0.1160 
                 0.0003 
                 0.0017 
               
               
                 1504 
                 0.8159 
                 0.2659 
                 0.0072 
                 0.0094 
                 0.3279 
                 0.1496 
               
               
                 1506 
                 0.0715 
                 0.0547 
                 0.2859 
                 0.1057 
                 0.0022 
                 0.0046 
               
               
                 1517 
                 0.7317 
                 0.2468 
                 0.0046 
                 0.0069 
                 0.0445 
                 0.0332 
               
               
                 1518 
                 0.5518 
                 0.2056 
                 0.0733 
                 0.0392 
                 0.7864 
                 0.2891 
               
               
                 1519 
                 0.3448 
                 0.1469 
                 0.0184 
                 0.0170 
                 0.5347 
                 0.2182 
               
               
                 1521 
                 0.7746 
                 0.2568 
                 0.8307 
                 0.2231 
                 0.5747 
                 0.2301 
               
               
                 1522 
                 0.9261 
                 0.2915 
                 0.0898 
                 0.0447 
                 0.1337 
                 0.0750 
               
               
                 1523 
                 0.8055 
                 0.2640 
                 0.0315 
                 0.0235 
                 0.6361 
                 0.2511 
               
               
                 1524 
                 0.6031 
                 0.2164 
                 0.0004 
                 0.0022 
                 0.0360 
                 0.0288 
               
               
                 1527 
                 0.0665 
                 0.0522 
                 0.1610 
                 0.0696 
                 0.0940 
                 0.0576 
               
               
                 1528 
                 0.2146 
                 0.1060 
                 0.2077 
                 0.0853 
                 0.0377 
                 0.0295 
               
               
                 1529 
                 0.3545 
                 0.1489 
                 0.3191 
                 0.1152 
                 0.2719 
                 0.1305 
               
               
                 1536 
                 0.6262 
                 0.2210 
                 0.1112 
                 0.0519 
                 0.6477 
                 0.2526 
               
               
                 1537 
                 0.8225 
                 0.2675 
                 0.2419 
                 0.0938 
                 0.3417 
                 0.1534 
               
               
                 1539 
                 0.2014 
                 0.1021 
                 0.0827 
                 0.0426 
                 0.0004 
                 0.0018 
               
               
                 1541 
                 0.1004 
                 0.0660 
                 0.0157 
                 0.0152 
                 0.0395 
                 0.0306 
               
               
                 1542 
                 0.3747 
                 0.1548 
                 0.0708 
                 0.0385 
                 0.3478 
                 0.1549 
               
               
                 1547 
                 0.5716 
                 0.2107 
                 0.9753 
                 0.2508 
                 0.0327 
                 0.0265 
               
               
                 1565 
                 0.9697 
                 0.3014 
                 0.1068 
                 0.0509 
                 0.7466 
                 0.2814 
               
               
                 1567 
                 0.9168 
                 0.2896 
                 0.0633 
                 0.0361 
                 0.7791 
                 0.2875 
               
               
                 1582 
                 0.6348 
                 0.2231 
                 0.9787 
                 0.2513 
                 0.9842 
                 0.3356 
               
               
                 1711 
                 0.4223 
                 0.1677 
                 0.0600 
                 0.0347 
                 0.1683 
                 0.0913 
               
               
                 1718 
                 0.0160 
                 0.0282 
                 0.0500 
                 0.0315 
                 0.0027 
                 0.0053 
               
               
                 1721 
                 0.0170 
                 0.0287 
                 0.2792 
                 0.1053 
                 0.1217 
                 0.0697 
               
               
                 1731 
                 0.1086 
                 0.0705 
                 0.1284 
                 0.0578 
                 0.1056 
                 0.0627 
               
               
                 1732 
                 0.0286 
                 0.0345 
                 0.1384 
                 0.0619 
                 0.0282 
                 0.0241 
               
               
                 1744 
                 0.0207 
                 0.0316 
                 0.0809 
                 0.0420 
                 0.0226 
                 0.0213 
               
               
                 1753 
                 0.0277 
                 0.0345 
                 0.0025 
                 0.0055 
                 0.0006 
                 0.0023 
               
               
                 1754 
                 0.0125 
                 0.0248 
                 0.3481 
                 0.1228 
                 0.9189 
                 0.3196 
               
               
                 1782 
                 0.0003 
                 0.0041 
                 0.0289 
                 0.0222 
                 0.0007 
                 0.0024 
               
               
                 1783 
                 0.1458 
                 0.0850 
                 0.3440 
                 0.1219 
                 0.5211 
                 0.2144 
               
               
                 1784 
                 0.5126 
                 0.1952 
                 0.0039 
                 0.0065 
                 0.0645 
                 0.0431 
               
               
                 1786 
                 0.7888 
                 0.2600 
                 0.0000 
                 0.0002 
                 0.1827 
                 0.0966 
               
               
                 1788 
                 0.0463 
                 0.0435 
                 0.0035 
                 0.0064 
                 0.0017 
                 0.0038 
               
               
                 1789 
                 0.0629 
                 0.0518 
                 0.0061 
                 0.0083 
                 0.0131 
                 0.0150 
               
               
                 1790 
                 0.2736 
                 0.1246 
                 0.0007 
                 0.0030 
                 0.0164 
                 0.0170 
               
               
                 1791 
                 0.0956 
                 0.0642 
                 0.0729 
                 0.0392 
                 0.0086 
                 0.0109 
               
               
                 1792 
                 0.0243 
                 0.0336 
                 0.0732 
                 0.0392 
                 0.0004 
                 0.0018 
               
               
                 1793 
                 0.0018 
                 0.0110 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 1811 
                 0.2022 
                 0.1022 
                 0.0224 
                 0.0189 
                 0.0136 
                 0.0154 
               
               
                 1815 
                 0.0511 
                 0.0462 
                 0.0210 
                 0.0183 
                 0.0359 
                 0.0288 
               
               
                 1827 
                 0.0410 
                 0.0412 
                 0.0038 
                 0.0065 
                 0.0095 
                 0.0116 
               
               
                 1828 
                 0.2319 
                 0.1105 
                 0.0908 
                 0.0447 
                 0.0269 
                 0.0234 
               
               
                 1829 
                 0.0521 
                 0.0466 
                 0.0003 
                 0.0022 
                 0.0030 
                 0.0056 
               
               
                 1831 
                 0.0691 
                 0.0535 
                 0.0087 
                 0.0104 
                 0.0130 
                 0.0150 
               
               
                 1834 
                 0.0912 
                 0.0631 
                 0.8257 
                 0.2228 
                 0.7553 
                 0.2831 
               
               
                 1837 
                 0.0672 
                 0.0525 
                 0.4757 
                 0.1514 
                 0.6439 
                 0.2521 
               
               
                 1841 
                 0.0114 
                 0.0232 
                 0.7067 
                 0.1998 
                 0.2837 
                 0.1345 
               
               
                 1845 
                 0.0922 
                 0.0633 
                 0.0090 
                 0.0106 
                 0.0198 
                 0.0193 
               
               
                 1851 
                 0.0139 
                 0.0262 
                 0.0306 
                 0.0232 
                 0.0006 
                 0.0024 
               
               
                 1866 
                 0.0090 
                 0.0213 
                 0.0019 
                 0.0050 
                 0.0001 
                 0.0008 
               
               
                 1867 
                 0.0499 
                 0.0455 
                 0.0160 
                 0.0152 
                 0.0014 
                 0.0036 
               
               
                 1870 
                 0.0405 
                 0.0411 
                 0.4123 
                 0.1381 
                 0.8618 
                 0.3088 
               
               
                 1878 
                 0.0375 
                 0.0394 
                 0.0120 
                 0.0128 
                 0.0013 
                 0.0034 
               
               
                 1884 
                 0.0288 
                 0.0345 
                 0.0973 
                 0.0471 
                 0.0017 
                 0.0038 
               
               
                 1889 
                 0.5884 
                 0.2138 
                 0.7778 
                 0.2137 
                 0.1166 
                 0.0676 
               
               
                 1892 
                 0.0752 
                 0.0566 
                 0.3546 
                 0.1245 
                 0.2182 
                 0.1094 
               
               
                 1902 
                 0.0538 
                 0.0476 
                 0.3969 
                 0.1348 
                 0.0084 
                 0.0109 
               
               
                 1903 
                 0.0006 
                 0.0059 
                 0.6230 
                 0.1829 
                 0.5669 
                 0.2280 
               
               
                 1907 
                 0.2068 
                 0.1033 
                 0.8675 
                 0.2305 
                 0.9916 
                 0.3375 
               
               
                 1945 
                 0.0786 
                 0.0581 
                 0.0850 
                 0.0430 
                 0.0159 
                 0.0168 
               
               
                 1948 
                 0.0559 
                 0.0485 
                 0.0044 
                 0.0068 
                 0.0022 
                 0.0046 
               
               
                 1949 
                 0.0343 
                 0.0378 
                 0.1087 
                 0.0511 
                 0.0031 
                 0.0056 
               
               
                 1950 
                 0.2685 
                 0.1232 
                 0.3529 
                 0.1242 
                 0.8509 
                 0.3064 
               
               
                 1953 
                 0.0886 
                 0.0623 
                 0.4607 
                 0.1488 
                 0.1507 
                 0.0824 
               
               
                 1955 
                 0.2317 
                 0.1105 
                 0.7745 
                 0.2132 
                 0.0378 
                 0.0295 
               
               
                 1962 
                 0.0467 
                 0.0435 
                 0.0585 
                 0.0344 
                 0.0029 
                 0.0055 
               
               
                 1970 
                 0.0617 
                 0.0518 
                 0.2124 
                 0.0861 
                 0.0138 
                 0.0155 
               
               
                 1974 
                 0.0868 
                 0.0616 
                 0.4107 
                 0.1378 
                 0.0084 
                 0.0109 
               
               
                 1975 
                 0.3281 
                 0.1423 
                 0.6139 
                 0.1813 
                 0.5231 
                 0.2148 
               
               
                 1976 
                 0.1638 
                 0.0923 
                 0.3077 
                 0.1118 
                 0.8335 
                 0.3030 
               
               
                 1979 
                 0.4077 
                 0.1638 
                 0.5491 
                 0.1677 
                 0.7717 
                 0.2864 
               
               
                 1982 
                 0.4393 
                 0.1733 
                 0.8521 
                 0.2272 
                 0.1430 
                 0.0793 
               
               
                 1985 
                 0.2107 
                 0.1043 
                 0.4184 
                 0.1394 
                 0.8870 
                 0.3131 
               
               
                 2016 
                 0.2000 
                 0.1020 
                 0.3786 
                 0.1307 
                 0.2785 
                 0.1328 
               
               
                 2021 
                 0.2644 
                 0.1217 
                 0.2679 
                 0.1018 
                 0.1227 
                 0.0699 
               
               
                 2024 
                 0.1691 
                 0.0924 
                 0.4538 
                 0.1476 
                 0.1497 
                 0.0821 
               
               
                 2034 
                 0.0629 
                 0.0518 
                 0.0021 
                 0.0053 
                 0.0027 
                 0.0053 
               
               
                 2052 
                 0.0363 
                 0.0394 
                 0.1278 
                 0.0577 
                 0.0064 
                 0.0092 
               
               
                 2067 
                 0.0224 
                 0.0321 
                 0.0593 
                 0.0346 
                 0.0082 
                 0.0108 
               
               
                 2072 
                 0.0453 
                 0.0429 
                 0.5134 
                 0.1588 
                 0.0280 
                 0.0240 
               
               
                 2105 
                 0.3666 
                 0.1522 
                 0.0287 
                 0.0222 
                 0.0529 
                 0.0373 
               
               
                 2106 
                 0.5821 
                 0.2132 
                 0.0201 
                 0.0177 
                 0.1236 
                 0.0702 
               
               
                 2107 
                 0.4095 
                 0.1641 
                 0.0375 
                 0.0264 
                 0.1132 
                 0.0660 
               
               
                 2113 
                 0.5529 
                 0.2056 
                 0.0359 
                 0.0259 
                 0.1489 
                 0.0819 
               
               
                 2115 
                 0.4946 
                 0.1903 
                 0.0558 
                 0.0337 
                 0.0822 
                 0.0532 
               
               
                 2118 
                 0.1650 
                 0.0923 
                 0.2025 
                 0.0838 
                 0.5402 
                 0.2200 
               
               
                 2136 
                 0.1751 
                 0.0947 
                 0.3200 
                 0.1152 
                 0.0845 
                 0.0540 
               
               
                 2157 
                 0.4918 
                 0.1901 
                 0.0437 
                 0.0290 
                 0.1009 
                 0.0607 
               
               
                 2164 
                 0.0747 
                 0.0566 
                 0.0102 
                 0.0117 
                 0.0034 
                 0.0059 
               
               
                 2165 
                 0.1129 
                 0.0719 
                 0.3057 
                 0.1116 
                 0.1384 
                 0.0772 
               
               
                 2166 
                 0.5884 
                 0.2138 
                 0.0952 
                 0.0463 
                 0.1986 
                 0.1017 
               
               
                 2168 
                 0.4012 
                 0.1623 
                 0.2840 
                 0.1053 
                 0.8893 
                 0.3131 
               
               
                 2179 
                 0.5866 
                 0.2138 
                 0.0575 
                 0.0343 
                 0.4381 
                 0.1834 
               
               
                 2192 
                 0.2598 
                 0.1201 
                 0.0312 
                 0.0235 
                 0.2109 
                 0.1066 
               
               
                 2193 
                 0.6240 
                 0.2207 
                 0.0152 
                 0.0149 
                 0.2129 
                 0.1073 
               
               
                 2194 
                 0.1190 
                 0.0741 
                 0.0888 
                 0.0443 
                 0.0485 
                 0.0353 
               
               
                 2199 
                 0.0448 
                 0.0428 
                 0.3891 
                 0.1330 
                 0.0138 
                 0.0155 
               
               
                 2203 
                 0.1164 
                 0.0732 
                 0.6948 
                 0.1988 
                 0.2237 
                 0.1119 
               
               
                 2206 
                 0.1325 
                 0.0788 
                 0.0645 
                 0.0366 
                 0.0254 
                 0.0229 
               
               
                 2209 
                 0.0833 
                 0.0605 
                 0.0417 
                 0.0281 
                 0.0139 
                 0.0155 
               
               
                 2211 
                 0.2750 
                 0.1249 
                 0.0560 
                 0.0337 
                 0.0920 
                 0.0569 
               
               
                 2217 
                 0.0385 
                 0.0399 
                 0.6518 
                 0.1894 
                 0.0255 
                 0.0229 
               
               
                 2310 
                 0.3826 
                 0.1563 
                 0.6344 
                 0.1859 
                 0.4011 
                 0.1721 
               
               
                 2311 
                 0.4184 
                 0.1665 
                 0.2032 
                 0.0839 
                 0.9296 
                 0.3227 
               
               
                 2312 
                 0.0036 
                 0.0164 
                 0.0008 
                 0.0033 
                 0.0001 
                 0.0006 
               
               
                 2313 
                 0.4932 
                 0.1902 
                 0.2142 
                 0.0861 
                 0.0865 
                 0.0547 
               
               
                 2314 
                 0.1989 
                 0.1020 
                 0.9039 
                 0.2371 
                 0.3942 
                 0.1702 
               
               
                 2318 
                 0.2850 
                 0.1284 
                 0.8459 
                 0.2260 
                 0.1606 
                 0.0875 
               
               
                 2327 
                 0.1595 
                 0.0915 
                 0.7144 
                 0.2004 
                 0.2137 
                 0.1074 
               
               
                 2343 
                 0.0140 
                 0.0262 
                 0.0073 
                 0.0094 
                 0.0005 
                 0.0022 
               
               
                 2345 
                 0.0547 
                 0.0477 
                 0.4353 
                 0.1439 
                 0.0075 
                 0.0103 
               
               
                 2347 
                 0.0150 
                 0.0273 
                 0.0160 
                 0.0152 
                 0.0003 
                 0.0014 
               
               
                 2348 
                 0.6456 
                 0.2260 
                 0.2830 
                 0.1053 
                 0.8884 
                 0.3131 
               
               
                 2350 
                 0.1878 
                 0.0980 
                 0.2129 
                 0.0861 
                 0.2994 
                 0.1399 
               
               
                 2351 
                 0.0004 
                 0.0051 
                 0.0402 
                 0.0275 
                 0.0017 
                 0.0038 
               
               
                 2356 
                 0.0198 
                 0.0311 
                 0.0022 
                 0.0053 
                 0.0283 
                 0.0241 
               
               
                 2357 
                 0.1659 
                 0.0923 
                 0.4181 
                 0.1394 
                 0.3269 
                 0.1495 
               
               
                 2360 
                 0.2235 
                 0.1081 
                 0.4487 
                 0.1471 
                 0.2069 
                 0.1051 
               
               
                 2361 
                 0.3381 
                 0.1452 
                 0.7991 
                 0.2179 
                 0.6023 
                 0.2402 
               
               
                 2364 
                 0.1868 
                 0.0980 
                 0.5694 
                 0.1720 
                 0.3092 
                 0.1428 
               
               
                 2371 
                 0.1001 
                 0.0660 
                 0.8120 
                 0.2202 
                 0.6437 
                 0.2521 
               
               
                 2374 
                 0.0525 
                 0.0467 
                 0.7956 
                 0.2177 
                 0.2565 
                 0.1241 
               
               
                 2375 
                 0.2803 
                 0.1269 
                 0.1729 
                 0.0737 
                 0.2444 
                 0.1201 
               
               
                 2376 
                 0.1088 
                 0.0705 
                 0.1646 
                 0.0710 
                 0.0993 
                 0.0601 
               
               
                 2379 
                 0.1843 
                 0.0975 
                 0.2257 
                 0.0891 
                 0.0827 
                 0.0532 
               
               
                 2381 
                 0.0891 
                 0.0624 
                 0.2917 
                 0.1070 
                 0.6854 
                 0.2625 
               
               
                 2383 
                 0.0643 
                 0.0521 
                 0.5668 
                 0.1716 
                 0.1260 
                 0.0711 
               
               
                 2394 
                 0.0210 
                 0.0316 
                 0.3783 
                 0.1307 
                 0.0611 
                 0.0415 
               
               
                 2395 
                 0.0038 
                 0.0164 
                 0.5901 
                 0.1768 
                 0.3208 
                 0.1471 
               
               
                 2407 
                 0.0991 
                 0.0657 
                 0.0869 
                 0.0437 
                 0.3387 
                 0.1526 
               
               
                 2411 
                 0.0649 
                 0.0521 
                 0.0837 
                 0.0427 
                 0.0371 
                 0.0294 
               
               
                 2413 
                 0.0001 
                 0.0027 
                 0.0694 
                 0.0382 
                 0.0038 
                 0.0064 
               
               
                 2416 
                 0.6176 
                 0.2196 
                 0.1180 
                 0.0541 
                 0.3773 
                 0.1644 
               
               
                 2418 
                 0.0046 
                 0.0169 
                 0.6502 
                 0.1894 
                 0.3113 
                 0.1434 
               
               
                 2419 
                 0.1624 
                 0.0922 
                 0.8803 
                 0.2330 
                 0.1207 
                 0.0693 
               
               
                 2420 
                 0.0372 
                 0.0394 
                 0.1086 
                 0.0511 
                 0.0214 
                 0.0204 
               
               
                 2422 
                 0.0598 
                 0.0509 
                 0.9172 
                 0.2393 
                 0.0083 
                 0.0108 
               
               
                 2423 
                 0.0094 
                 0.0213 
                 0.2131 
                 0.0861 
                 0.0000 
                 0.0004 
               
               
                 2426 
                 0.0005 
                 0.0054 
                 0.2399 
                 0.0932 
                 0.0087 
                 0.0109 
               
               
                 2429 
                 0.2051 
                 0.1030 
                 0.4357 
                 0.1439 
                 0.1204 
                 0.0693 
               
               
                 2431 
                 0.0469 
                 0.0435 
                 0.6202 
                 0.1825 
                 0.1842 
                 0.0969 
               
               
                 2432 
                 0.0083 
                 0.0209 
                 0.7253 
                 0.2027 
                 0.1761 
                 0.0942 
               
               
                 2442 
                 0.1478 
                 0.0859 
                 0.8064 
                 0.2193 
                 0.7849 
                 0.2891 
               
               
                 2443 
                 0.0163 
                 0.0285 
                 0.0428 
                 0.0285 
                 0.0537 
                 0.0374 
               
               
                 2445 
                 0.0450 
                 0.0428 
                 0.3723 
                 0.1296 
                 0.0526 
                 0.0372 
               
               
                 2448 
                 0.5207 
                 0.1970 
                 0.5978 
                 0.1787 
                 0.0149 
                 0.0161 
               
               
                 2449 
                 0.0055 
                 0.0186 
                 0.0219 
                 0.0186 
                 0.0002 
                 0.0014 
               
               
                 2474 
                 0.1808 
                 0.0961 
                 0.1395 
                 0.0619 
                 0.0590 
                 0.0404 
               
               
                 2480 
                 0.0045 
                 0.0169 
                 0.0332 
                 0.0243 
                 0.0005 
                 0.0022 
               
               
                 2481 
                 0.0371 
                 0.0394 
                 0.0107 
                 0.0120 
                 0.0001 
                 0.0008 
               
               
                 2488 
                 0.0029 
                 0.0150 
                 0.0703 
                 0.0385 
                 0.0000 
                 0.0004 
               
               
                 2491 
                 0.0167 
                 0.0286 
                 0.0024 
                 0.0055 
                 0.0004 
                 0.0020 
               
               
                 2493 
                 0.0060 
                 0.0195 
                 0.0026 
                 0.0055 
                 0.0002 
                 0.0014 
               
               
                 2498 
                 0.0885 
                 0.0623 
                 0.0306 
                 0.0232 
                 0.0016 
                 0.0038 
               
               
                 2499 
                 0.0104 
                 0.0222 
                 0.0130 
                 0.0134 
                 0.0044 
                 0.0072 
               
               
                 2513 
                 0.0028 
                 0.0145 
                 0.1401 
                 0.0619 
                 0.0019 
                 0.0042 
               
               
                 2514 
                 0.0106 
                 0.0222 
                 0.0012 
                 0.0040 
                 0.0001 
                 0.0008 
               
               
                 2517 
                 0.0194 
                 0.0310 
                 0.0676 
                 0.0378 
                 0.0012 
                 0.0034 
               
               
                 2518 
                 0.0003 
                 0.0041 
                 0.0025 
                 0.0055 
                 0.0008 
                 0.0027 
               
               
                 2520 
                 0.1306 
                 0.0780 
                 0.4579 
                 0.1482 
                 0.2646 
                 0.1277 
               
               
                 2522 
                 0.8132 
                 0.2655 
                 0.4760 
                 0.1514 
                 0.3804 
                 0.1653 
               
               
                 2523 
                 0.1104 
                 0.0713 
                 0.0936 
                 0.0457 
                 0.0270 
                 0.0234 
               
               
                 2525 
                 0.2281 
                 0.1096 
                 0.2717 
                 0.1028 
                 0.7022 
                 0.2668 
               
               
                 2543 
                 0.3249 
                 0.1413 
                 0.5644 
                 0.1712 
                 0.5335 
                 0.2182 
               
               
                 2547 
                 0.0437 
                 0.0428 
                 0.4813 
                 0.1520 
                 0.8825 
                 0.3131 
               
               
                 2549 
                 0.7965 
                 0.2620 
                 0.4758 
                 0.1514 
                 0.2817 
                 0.1339 
               
               
                 2561 
                 0.0273 
                 0.0345 
                 0.0440 
                 0.0290 
                 0.0412 
                 0.0313 
               
               
                 2563 
                 0.1660 
                 0.0923 
                 0.0064 
                 0.0086 
                 0.0079 
                 0.0107 
               
               
                 2564 
                 0.0206 
                 0.0316 
                 0.0029 
                 0.0060 
                 0.0013 
                 0.0034 
               
               
                 2565 
                 0.7399 
                 0.2482 
                 0.1970 
                 0.0818 
                 0.8012 
                 0.2923 
               
               
                 2566 
                 0.0719 
                 0.0548 
                 0.0466 
                 0.0302 
                 0.1348 
                 0.0754 
               
               
                 2567 
                 0.6504 
                 0.2261 
                 0.0375 
                 0.0264 
                 0.0429 
                 0.0321 
               
               
                 2568 
                 0.0958 
                 0.0642 
                 0.0030 
                 0.0060 
                 0.0009 
                 0.0027 
               
               
                 2569 
                 0.0424 
                 0.0418 
                 0.0188 
                 0.0171 
                 0.1251 
                 0.0708 
               
               
                 2570 
                 0.0657 
                 0.0521 
                 0.0014 
                 0.0042 
                 0.0126 
                 0.0147 
               
               
                 2575 
                 0.5810 
                 0.2132 
                 0.2394 
                 0.0932 
                 0.7882 
                 0.2892 
               
               
                 2577 
                 0.6112 
                 0.2184 
                 0.0852 
                 0.0430 
                 0.2963 
                 0.1388 
               
               
                 2579 
                 0.1690 
                 0.0924 
                 0.0378 
                 0.0264 
                 0.3443 
                 0.1542 
               
               
                 2580 
                 0.0682 
                 0.0531 
                 0.0007 
                 0.0032 
                 0.0045 
                 0.0072 
               
               
                 2581 
                 0.5201 
                 0.1970 
                 0.0367 
                 0.0262 
                 0.1406 
                 0.0782 
               
               
                 2583 
                 0.1795 
                 0.0960 
                 0.0045 
                 0.0069 
                 0.0048 
                 0.0076 
               
               
                 2588 
                 0.2229 
                 0.1081 
                 0.0267 
                 0.0217 
                 0.0728 
                 0.0481 
               
               
                 2591 
                 0.3315 
                 0.1431 
                 0.0211 
                 0.0183 
                 0.0040 
                 0.0066 
               
               
                 2592 
                 0.0085 
                 0.0209 
                 0.0161 
                 0.0152 
                 0.4130 
                 0.1744 
               
               
                 2594 
                 0.1249 
                 0.0764 
                 0.0578 
                 0.0343 
                 0.0357 
                 0.0288 
               
               
                 2610 
                 0.0764 
                 0.0567 
                 0.0013 
                 0.0040 
                 0.0039 
                 0.0065 
               
               
                 2624 
                 0.3112 
                 0.1367 
                 0.0280 
                 0.0222 
                 0.0088 
                 0.0110 
               
               
                 2625 
                 0.1087 
                 0.0705 
                 0.0212 
                 0.0183 
                 0.0052 
                 0.0080 
               
               
                 2649 
                 0.3812 
                 0.1563 
                 0.0407 
                 0.0278 
                 0.8738 
                 0.3112 
               
               
                 2652 
                 0.2180 
                 0.1073 
                 0.0672 
                 0.0377 
                 0.0066 
                 0.0093 
               
               
                 2669 
                 0.6185 
                 0.2196 
                 0.0772 
                 0.0405 
                 0.8669 
                 0.3093 
               
               
                 3453 
                 0.0242 
                 0.0336 
                 0.0542 
                 0.0334 
                 0.0031 
                 0.0056 
               
               
                 3454 
                 0.0444 
                 0.0428 
                 0.0494 
                 0.0312 
                 0.0012 
                 0.0033 
               
               
                 3455 
                 0.0019 
                 0.0111 
                 0.0012 
                 0.0040 
                 0.0000 
                 0.0002 
               
               
                 3456 
                 0.1786 
                 0.0958 
                 0.0475 
                 0.0305 
                 0.0014 
                 0.0034 
               
               
                 3458 
                 0.0003 
                 0.0041 
                 0.0613 
                 0.0352 
                 0.0000 
                 0.0002 
               
               
                 3461 
                 0.1908 
                 0.0992 
                 0.0125 
                 0.0132 
                 0.0263 
                 0.0231 
               
               
                 3462 
                 0.3962 
                 0.1610 
                 0.2241 
                 0.0887 
                 0.0066 
                 0.0093 
               
               
                 3464 
                 0.3465 
                 0.1470 
                 0.0005 
                 0.0026 
                 0.0306 
                 0.0253 
               
               
                 3466 
                 0.0265 
                 0.0342 
                 0.0021 
                 0.0053 
                 0.0006 
                 0.0022 
               
               
                 3471 
                 0.9736 
                 0.3020 
                 0.0529 
                 0.0331 
                 0.6629 
                 0.2558 
               
               
                 3472 
                 0.9410 
                 0.2935 
                 0.8073 
                 0.2193 
                 0.3894 
                 0.1685 
               
               
                 3473 
                 0.3425 
                 0.1467 
                 0.1141 
                 0.0526 
                 0.4976 
                 0.2061 
               
               
                 3474 
                 0.1635 
                 0.0923 
                 0.0402 
                 0.0275 
                 0.6912 
                 0.2636 
               
               
                 3478 
                 0.0289 
                 0.0345 
                 0.0589 
                 0.0345 
                 0.0095 
                 0.0116 
               
               
                 3479 
                 0.1493 
                 0.0865 
                 0.1882 
                 0.0790 
                 0.5662 
                 0.2280 
               
               
                 3480 
                 0.5984 
                 0.2156 
                 0.8916 
                 0.2354 
                 0.9427 
                 0.3261 
               
               
                 3485 
                 0.0114 
                 0.0232 
                 0.0012 
                 0.0040 
                 0.0008 
                 0.0027 
               
               
                 3495 
                 0.0979 
                 0.0651 
                 0.0041 
                 0.0067 
                 0.0034 
                 0.0059 
               
               
                 3498 
                 0.5917 
                 0.2140 
                 0.1733 
                 0.0737 
                 0.2553 
                 0.1240 
               
               
                 3505 
                 0.0114 
                 0.0232 
                 0.0556 
                 0.0337 
                 0.0013 
                 0.0034 
               
               
                 3507 
                 0.0797 
                 0.0586 
                 0.0106 
                 0.0120 
                 0.0228 
                 0.0214 
               
               
                 3508 
                 0.0021 
                 0.0118 
                 0.0537 
                 0.0332 
                 0.0009 
                 0.0028 
               
               
                 3513 
                 0.2646 
                 0.1217 
                 0.6812 
                 0.1968 
                 0.3490 
                 0.1549 
               
               
                 3514 
                 0.3741 
                 0.1548 
                 0.4891 
                 0.1535 
                 0.6556 
                 0.2546 
               
               
                 3516 
                 0.0065 
                 0.0199 
                 0.0014 
                 0.0042 
                 0.0012 
                 0.0033 
               
               
                 3522 
                 0.1280 
                 0.0775 
                 0.0035 
                 0.0064 
                 0.0298 
                 0.0247 
               
               
                 3528 
                 0.2914 
                 0.1299 
                 0.0835 
                 0.0427 
                 0.0161 
                 0.0169 
               
               
                 3530 
                 0.6132 
                 0.2186 
                 0.7112 
                 0.2003 
                 0.4071 
                 0.1735 
               
               
                 3533 
                 0.2981 
                 0.1322 
                 0.4774 
                 0.1515 
                 0.0028 
                 0.0055 
               
               
                 3534 
                 0.8764 
                 0.2804 
                 0.6160 
                 0.1816 
                 0.0061 
                 0.0089 
               
               
                 3535 
                 0.9155 
                 0.2896 
                 0.0937 
                 0.0457 
                 0.6611 
                 0.2557 
               
               
                 3537 
                 0.0338 
                 0.0377 
                 0.0151 
                 0.0149 
                 0.0419 
                 0.0316 
               
               
                 3541 
                 0.1127 
                 0.0719 
                 0.6886 
                 0.1974 
                 0.0873 
                 0.0549 
               
               
                 3542 
                 0.7662 
                 0.2549 
                 0.9583 
                 0.2475 
                 0.2509 
                 0.1226 
               
               
                 3547 
                 0.0007 
                 0.0065 
                 0.0077 
                 0.0096 
                 0.0000 
                 0.0002 
               
               
                 3548 
                 0.0010 
                 0.0080 
                 0.0613 
                 0.0352 
                 0.0001 
                 0.0006 
               
               
                 3549 
                 0.7416 
                 0.2482 
                 0.0088 
                 0.0105 
                 0.0532 
                 0.0374 
               
               
                 3550 
                 0.5658 
                 0.2094 
                 0.0190 
                 0.0171 
                 0.0142 
                 0.0156 
               
               
                 3552 
                 0.4037 
                 0.1629 
                 0.4328 
                 0.1436 
                 0.0426 
                 0.0320 
               
               
                 3563 
                 0.4968 
                 0.1904 
                 0.1138 
                 0.0526 
                 0.2681 
                 0.1291 
               
               
                 3565 
                 0.1300 
                 0.0780 
                 0.0420 
                 0.0281 
                 0.0635 
                 0.0427 
               
               
                 3566 
                 0.1118 
                 0.0717 
                 0.0036 
                 0.0064 
                 0.0015 
                 0.0037 
               
               
                 3567 
                 0.0657 
                 0.0521 
                 0.0038 
                 0.0065 
                 0.0053 
                 0.0080 
               
               
                 3568 
                 0.0569 
                 0.0489 
                 0.0192 
                 0.0172 
                 0.7120 
                 0.2700 
               
               
                 3572 
                 0.0334 
                 0.0377 
                 0.5222 
                 0.1604 
                 0.0886 
                 0.0554 
               
               
                 3573 
                 0.2473 
                 0.1167 
                 0.8240 
                 0.2228 
                 0.5571 
                 0.2259 
               
               
                 3576 
                 0.0102 
                 0.0222 
                 0.0288 
                 0.0222 
                 0.0221 
                 0.0210 
               
               
                 3577 
                 0.0001 
                 0.0026 
                 0.0033 
                 0.0064 
                 0.0000 
                 0.0002 
               
               
                 3578 
                 0.2476 
                 0.1167 
                 0.3862 
                 0.1326 
                 0.9624 
                 0.3309 
               
               
                 3579 
                 0.0043 
                 0.0169 
                 0.0034 
                 0.0064 
                 0.0011 
                 0.0033 
               
               
                 3580 
                 0.0954 
                 0.0642 
                 0.0111 
                 0.0123 
                 0.0250 
                 0.0227 
               
               
                 3585 
                 0.0252 
                 0.0338 
                 0.5135 
                 0.1588 
                 0.2787 
                 0.1328 
               
               
                 3587 
                 0.0000 
                 0.0001 
                 0.0001 
                 0.0007 
                 0.0000 
                 0.0000 
               
               
                 3588 
                 0.0078 
                 0.0209 
                 0.0005 
                 0.0026 
                 0.0003 
                 0.0017 
               
               
                 3589 
                 0.0059 
                 0.0193 
                 0.0008 
                 0.0033 
                 0.0013 
                 0.0034 
               
               
                 3598 
                 0.0039 
                 0.0164 
                 0.0367 
                 0.0262 
                 0.0003 
                 0.0014 
               
               
                 3599 
                 0.6955 
                 0.2387 
                 0.2867 
                 0.1057 
                 0.7785 
                 0.2875 
               
               
                 3602 
                 0.0654 
                 0.0521 
                 0.7969 
                 0.2177 
                 0.3002 
                 0.1400 
               
               
                 3603 
                 0.0080 
                 0.0209 
                 0.0315 
                 0.0235 
                 0.0411 
                 0.0313 
               
               
                 3607 
                 0.0470 
                 0.0435 
                 0.5630 
                 0.1712 
                 0.0297 
                 0.0247 
               
               
                 3608 
                 0.0223 
                 0.0321 
                 0.8988 
                 0.2365 
                 0.0510 
                 0.0366 
               
               
                 3624 
                 0.0054 
                 0.0186 
                 0.0067 
                 0.0089 
                 0.0055 
                 0.0083 
               
               
                 3627 
                 0.6088 
                 0.2180 
                 0.0478 
                 0.0305 
                 0.0782 
                 0.0511 
               
               
                 3628 
                 0.1849 
                 0.0975 
                 0.1812 
                 0.0765 
                 0.3182 
                 0.1462 
               
               
                 3636 
                 0.0064 
                 0.0199 
                 0.0597 
                 0.0347 
                 0.0392 
                 0.0305 
               
               
                 3641 
                 0.4532 
                 0.1780 
                 0.0025 
                 0.0055 
                 0.0005 
                 0.0022 
               
               
                 3643 
                 0.0003 
                 0.0041 
                 0.3915 
                 0.1336 
                 0.5707 
                 0.2290 
               
               
                 3644 
                 0.0040 
                 0.0164 
                 0.7307 
                 0.2038 
                 0.9146 
                 0.3192 
               
               
                 3648 
                 0.0849 
                 0.0610 
                 0.3833 
                 0.1320 
                 0.0461 
                 0.0341 
               
               
                 3649 
                 0.0424 
                 0.0418 
                 0.0007 
                 0.0030 
                 0.0005 
                 0.0022 
               
               
                 3650 
                 0.2000 
                 0.1020 
                 0.3075 
                 0.1118 
                 0.0965 
                 0.0587 
               
               
                 3651 
                 0.6854 
                 0.2376 
                 0.0044 
                 0.0069 
                 0.0002 
                 0.0014 
               
               
                 3653 
                 0.0092 
                 0.0213 
                 0.8277 
                 0.2228 
                 0.0163 
                 0.0170 
               
               
                 3654 
                 0.0761 
                 0.0567 
                 0.0481 
                 0.0305 
                 0.0002 
                 0.0011 
               
               
                 3656 
                 0.3493 
                 0.1475 
                 0.7140 
                 0.2004 
                 0.4046 
                 0.1732 
               
               
                 3658 
                 0.0368 
                 0.0394 
                 0.3339 
                 0.1189 
                 0.0258 
                 0.0229 
               
               
                 3662 
                 0.9285 
                 0.2917 
                 0.3212 
                 0.1153 
                 0.8509 
                 0.3064 
               
               
                 3663 
                 0.6881 
                 0.2376 
                 0.0771 
                 0.0405 
                 0.4082 
                 0.1735 
               
               
                 3664 
                 0.8371 
                 0.2708 
                 0.0375 
                 0.0264 
                 0.6870 
                 0.2626 
               
               
                 3667 
                 0.9126 
                 0.2896 
                 0.1669 
                 0.0717 
                 0.9067 
                 0.3176 
               
               
                 3668 
                 0.0261 
                 0.0342 
                 0.0056 
                 0.0078 
                 0.0215 
                 0.0204 
               
               
                 3670 
                 0.4144 
                 0.1653 
                 0.3356 
                 0.1193 
                 0.7271 
                 0.2752 
               
               
                 3694 
                 0.4864 
                 0.1893 
                 0.0004 
                 0.0025 
                 0.0017 
                 0.0038 
               
               
                 3698 
                 0.5218 
                 0.1970 
                 0.7344 
                 0.2041 
                 0.2026 
                 0.1032 
               
               
                 3714 
                 0.0031 
                 0.0157 
                 0.6019 
                 0.1792 
                 0.0027 
                 0.0053 
               
               
                 3715 
                 0.0103 
                 0.0222 
                 0.3680 
                 0.1286 
                 0.0731 
                 0.0482 
               
               
                 3718 
                 0.2237 
                 0.1081 
                 0.9102 
                 0.2379 
                 0.5205 
                 0.2144 
               
               
                 3727 
                 0.0000 
                 0.0008 
                 0.0001 
                 0.0006 
                 0.0000 
                 0.0000 
               
               
                 3728 
                 0.3102 
                 0.1366 
                 0.1275 
                 0.0577 
                 0.1000 
                 0.0603 
               
               
                 3751 
                 0.1212 
                 0.0752 
                 0.7036 
                 0.1994 
                 0.0008 
                 0.0027 
               
               
                 3754 
                 0.2859 
                 0.1285 
                 0.0837 
                 0.0427 
                 0.0032 
                 0.0056 
               
               
                 3757 
                 0.0000 
                 0.0008 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 3771 
                 0.6871 
                 0.2376 
                 0.8631 
                 0.2297 
                 0.8469 
                 0.3061 
               
               
                 3978 
                 0.5977 
                 0.2156 
                 0.1399 
                 0.0619 
                 0.7387 
                 0.2790 
               
               
                 4000 
                 0.7347 
                 0.2473 
                 0.0932 
                 0.0457 
                 0.2557 
                 0.1240 
               
               
                 4079 
                 0.8714 
                 0.2798 
                 0.1472 
                 0.0646 
                 0.0621 
                 0.0420 
               
               
                 4108 
                 0.0336 
                 0.0377 
                 0.0000 
                 0.0001 
                 0.0000 
                 0.0004 
               
               
                 4131 
                 0.7310 
                 0.2468 
                 0.9343 
                 0.2433 
                 0.6398 
                 0.2520 
               
               
                 4144 
                 0.6993 
                 0.2391 
                 0.0197 
                 0.0175 
                 0.1272 
                 0.0716 
               
               
                 4221 
                 0.0223 
                 0.0321 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0003 
               
               
                 4246 
                 0.0340 
                 0.0377 
                 0.0068 
                 0.0090 
                 0.6059 
                 0.2406 
               
               
                 4274 
                 0.8733 
                 0.2799 
                 0.0036 
                 0.0064 
                 0.0003 
                 0.0016 
               
               
                 4363 
                 0.8887 
                 0.2838 
                 0.0681 
                 0.0379 
                 0.2316 
                 0.1149 
               
               
                 4756 
                 0.4899 
                 0.1898 
                 0.0583 
                 0.0344 
                 0.0979 
                 0.0594 
               
               
                 4832 
                 0.2738 
                 0.1246 
                 0.2556 
                 0.0980 
                 0.4107 
                 0.1738 
               
               
                 4835 
                 0.7093 
                 0.2411 
                 0.0004 
                 0.0025 
                 0.0027 
                 0.0053 
               
               
                 4899 
                 0.1277 
                 0.0775 
                 0.5813 
                 0.1745 
                 0.0416 
                 0.0315 
               
               
                 4926 
                 0.8925 
                 0.2845 
                 0.8925 
                 0.2354 
                 0.0070 
                 0.0097 
               
               
                 4930 
                 0.0000 
                 0.0001 
                 0.2618 
                 0.0998 
                 0.0828 
                 0.0532 
               
               
                 4971 
                 0.1580 
                 0.0910 
                 0.5798 
                 0.1745 
                 0.1922 
                 0.1003 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 4E 
               
             
            
               
                   
                   
               
               
                   
                 Sp/ABX 
                 GF/ABX 
                 GF/Sp 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 PSO 
                 p-value 
                 q-value 
                 p-value 
                 q-value 
                 p-value 
                 q-value 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 1 
                 0.8917 
                 0.5563 
                 0.1267 
                 0.3091 
                 0.1609 
                 0.5562 
               
               
                 2 
                 0.5072 
                 0.4333 
                 0.2155 
                 0.3855 
                 0.0648 
                 0.4168 
               
               
                 5 
                 0.3900 
                 0.3727 
                 0.0802 
                 0.2676 
                 0.3465 
                 0.7016 
               
               
                 6 
                 0.0506 
                 0.1713 
                 0.0562 
                 0.2376 
                 0.9585 
                 0.8691 
               
               
                 9 
                 0.0641 
                 0.1838 
                 0.7898 
                 0.6001 
                 0.1067 
                 0.5131 
               
               
                 10 
                 0.8368 
                 0.5346 
                 0.2106 
                 0.3803 
                 0.1487 
                 0.5562 
               
               
                 14 
                 0.3008 
                 0.3317 
                 0.1547 
                 0.3609 
                 0.0194 
                 0.2317 
               
               
                 16 
                 0.8637 
                 0.5475 
                 0.2699 
                 0.4251 
                 0.2055 
                 0.5984 
               
               
                 17 
                 0.5051 
                 0.4333 
                 0.0564 
                 0.2376 
                 0.1932 
                 0.5864 
               
               
                 18 
                 0.5041 
                 0.4333 
                 0.4624 
                 0.5230 
                 0.9457 
                 0.8691 
               
               
                 21 
                 0.3804 
                 0.3666 
                 0.3223 
                 0.4661 
                 0.9073 
                 0.8681 
               
               
                 28 
                 0.8984 
                 0.5563 
                 0.7342 
                 0.5835 
                 0.6409 
                 0.8251 
               
               
                 30 
                 0.1043 
                 0.2278 
                 0.0667 
                 0.2508 
                 0.8144 
                 0.8519 
               
               
                 34 
                 0.9011 
                 0.5563 
                 0.8090 
                 0.6041 
                 0.9064 
                 0.8681 
               
               
                 35 
                 0.2546 
                 0.2999 
                 0.6489 
                 0.5695 
                 0.4855 
                 0.7453 
               
               
                 38 
                 0.9840 
                 0.5782 
                 0.9418 
                 0.6284 
                 0.9258 
                 0.8691 
               
               
                 39 
                 0.7121 
                 0.4942 
                 0.4316 
                 0.5036 
                 0.6730 
                 0.8315 
               
               
                 40 
                 0.1827 
                 0.2616 
                 0.9116 
                 0.6254 
                 0.2193 
                 0.6064 
               
               
                 41 
                 0.5689 
                 0.4508 
                 0.6138 
                 0.5695 
                 0.9476 
                 0.8691 
               
               
                 42 
                 0.0500 
                 0.1713 
                 0.5935 
                 0.5688 
                 0.0161 
                 0.2066 
               
               
                 43 
                 0.0000 
                 0.0007 
                 0.1850 
                 0.3746 
                 0.0000 
                 0.0001 
               
               
                 44 
                 0.8981 
                 0.5563 
                 0.8933 
                 0.6233 
                 0.9951 
                 0.8795 
               
               
                 45 
                 0.1288 
                 0.2311 
                 0.7327 
                 0.5835 
                 0.0679 
                 0.4298 
               
               
                 47 
                 0.0001 
                 0.0019 
                 0.9421 
                 0.6284 
                 0.0000 
                 0.0026 
               
               
                 50 
                 0.3096 
                 0.3368 
                 0.2838 
                 0.4431 
                 0.9536 
                 0.8691 
               
               
                 51 
                 0.0359 
                 0.1496 
                 0.0114 
                 0.1024 
                 0.0001 
                 0.0026 
               
               
                 52 
                 0.6346 
                 0.4691 
                 0.4478 
                 0.5190 
                 0.2233 
                 0.6097 
               
               
                 53 
                 0.5166 
                 0.4340 
                 0.3668 
                 0.4776 
                 0.1289 
                 0.5309 
               
               
                 54 
                 0.5193 
                 0.4340 
                 0.6166 
                 0.5695 
                 0.2579 
                 0.6316 
               
               
                 55 
                 0.7881 
                 0.5248 
                 0.2108 
                 0.3803 
                 0.3198 
                 0.6817 
               
               
                 56 
                 0.0863 
                 0.2155 
                 0.0374 
                 0.2039 
                 0.6752 
                 0.8321 
               
               
                 59 
                 0.0394 
                 0.1566 
                 0.0119 
                 0.1042 
                 0.5790 
                 0.7830 
               
               
                 65 
                 0.1339 
                 0.2311 
                 0.1067 
                 0.2848 
                 0.9002 
                 0.8681 
               
               
                 66 
                 0.0024 
                 0.0325 
                 0.0010 
                 0.0306 
                 0.7145 
                 0.8380 
               
               
                 67 
                 0.2056 
                 0.2747 
                 0.0711 
                 0.2551 
                 0.5567 
                 0.7770 
               
               
                 68 
                 0.0509 
                 0.1713 
                 0.7325 
                 0.5835 
                 0.0250 
                 0.2775 
               
               
                 74 
                 0.0000 
                 0.0000 
                 0.9507 
                 0.6291 
                 0.0000 
                 0.0000 
               
               
                 75 
                 0.0512 
                 0.1713 
                 0.2229 
                 0.3875 
                 0.4242 
                 0.7283 
               
               
                 76 
                 0.1850 
                 0.2618 
                 0.3984 
                 0.4995 
                 0.0369 
                 0.3243 
               
               
                 77 
                 0.7740 
                 0.5212 
                 0.6904 
                 0.5790 
                 0.9111 
                 0.8681 
               
               
                 80 
                 0.0181 
                 0.0987 
                 0.8231 
                 0.6041 
                 0.0111 
                 0.1537 
               
               
                 82 
                 0.2972 
                 0.3287 
                 0.9509 
                 0.6291 
                 0.3254 
                 0.6900 
               
               
                 83 
                 0.2580 
                 0.3016 
                 0.7178 
                 0.5835 
                 0.4344 
                 0.7283 
               
               
                 84 
                 0.4436 
                 0.4017 
                 0.6744 
                 0.5775 
                 0.7261 
                 0.8380 
               
               
                 92 
                 0.8109 
                 0.5274 
                 0.4620 
                 0.5230 
                 0.3329 
                 0.6976 
               
               
                 93 
                 0.0100 
                 0.0718 
                 0.5070 
                 0.5413 
                 0.0423 
                 0.3453 
               
               
                 99 
                 0.0217 
                 0.1120 
                 0.2581 
                 0.4219 
                 0.0016 
                 0.0466 
               
               
                 100 
                 0.1137 
                 0.2311 
                 0.9466 
                 0.6291 
                 0.1005 
                 0.5102 
               
               
                 101 
                 0.2485 
                 0.2999 
                 0.6493 
                 0.5695 
                 0.4757 
                 0.7453 
               
               
                 102 
                 0.1453 
                 0.2422 
                 0.1714 
                 0.3733 
                 0.9239 
                 0.8691 
               
               
                 103 
                 0.4127 
                 0.3838 
                 0.4558 
                 0.5230 
                 0.9401 
                 0.8691 
               
               
                 105 
                 0.3363 
                 0.3473 
                 0.7033 
                 0.5824 
                 0.5560 
                 0.7770 
               
               
                 107 
                 0.7779 
                 0.5212 
                 0.6755 
                 0.5775 
                 0.4855 
                 0.7453 
               
               
                 113 
                 0.1309 
                 0.2311 
                 0.1766 
                 0.3736 
                 0.0075 
                 0.1289 
               
               
                 114 
                 0.7008 
                 0.4913 
                 0.1085 
                 0.2848 
                 0.2116 
                 0.6023 
               
               
                 117 
                 0.4347 
                 0.3960 
                 0.3941 
                 0.4991 
                 0.1109 
                 0.5146 
               
               
                 119 
                 0.0000 
                 0.0000 
                 0.0059 
                 0.0770 
                 0.0000 
                 0.0000 
               
               
                 120 
                 0.3416 
                 0.3473 
                 0.6244 
                 0.5695 
                 0.1567 
                 0.5562 
               
               
                 121 
                 0.2413 
                 0.2964 
                 0.8079 
                 0.6041 
                 0.1615 
                 0.5562 
               
               
                 122 
                 0.4630 
                 0.4136 
                 0.8773 
                 0.6181 
                 0.5606 
                 0.7770 
               
               
                 126 
                 0.3134 
                 0.3388 
                 0.9179 
                 0.6254 
                 0.2684 
                 0.6409 
               
               
                 137 
                 0.4537 
                 0.4086 
                 0.2240 
                 0.3875 
                 0.0571 
                 0.4034 
               
               
                 138 
                 0.6950 
                 0.4913 
                 0.0519 
                 0.2360 
                 0.0229 
                 0.2599 
               
               
                 150 
                 0.0678 
                 0.1925 
                 0.6914 
                 0.5790 
                 0.0301 
                 0.2992 
               
               
                 154 
                 0.1614 
                 0.2443 
                 1.0000 
                 0.6499 
                 0.1614 
                 0.5562 
               
               
                 180 
                 0.8101 
                 0.5274 
                 0.8403 
                 0.6048 
                 0.6592 
                 0.8268 
               
               
                 181 
                 0.7774 
                 0.5212 
                 0.4219 
                 0.5036 
                 0.2816 
                 0.6480 
               
               
                 191 
                 0.1771 
                 0.2595 
                 0.2268 
                 0.3879 
                 0.8807 
                 0.8620 
               
               
                 210 
                 0.7774 
                 0.5212 
                 0.5512 
                 0.5606 
                 0.7526 
                 0.8380 
               
               
                 217 
                 0.2425 
                 0.2964 
                 0.6882 
                 0.5790 
                 0.4347 
                 0.7283 
               
               
                 221 
                 0.6866 
                 0.4905 
                 0.4818 
                 0.5299 
                 0.2734 
                 0.6411 
               
               
                 227 
                 0.0570 
                 0.1757 
                 0.0395 
                 0.2100 
                 0.8559 
                 0.8610 
               
               
                 241 
                 0.2015 
                 0.2715 
                 0.6268 
                 0.5695 
                 0.4182 
                 0.7283 
               
               
                 254 
                 0.0078 
                 0.0610 
                 0.0000 
                 0.0068 
                 0.0000 
                 0.0000 
               
               
                 261 
                 0.6739 
                 0.4870 
                 0.8377 
                 0.6041 
                 0.5328 
                 0.7770 
               
               
                 263 
                 0.4187 
                 0.3872 
                 0.3589 
                 0.4766 
                 0.9109 
                 0.8681 
               
               
                 265 
                 0.8984 
                 0.5563 
                 0.5609 
                 0.5622 
                 0.4794 
                 0.7453 
               
               
                 273 
                 0.7334 
                 0.5011 
                 0.1088 
                 0.2848 
                 0.1975 
                 0.5917 
               
               
                 280 
                 0.0391 
                 0.1566 
                 0.3214 
                 0.4661 
                 0.2478 
                 0.6228 
               
               
                 296 
                 0.1886 
                 0.2645 
                 0.8972 
                 0.6233 
                 0.2328 
                 0.6153 
               
               
                 299 
                 0.2279 
                 0.2893 
                 0.9055 
                 0.6254 
                 0.1876 
                 0.5850 
               
               
                 300 
                 0.2365 
                 0.2953 
                 0.5503 
                 0.5606 
                 0.5469 
                 0.7770 
               
               
                 301 
                 0.0108 
                 0.0724 
                 0.1225 
                 0.3029 
                 0.2442 
                 0.6224 
               
               
                 303 
                 0.7027 
                 0.4913 
                 0.6393 
                 0.5695 
                 0.9302 
                 0.8691 
               
               
                 306 
                 0.9759 
                 0.5766 
                 0.7557 
                 0.5925 
                 0.7787 
                 0.8418 
               
               
                 311 
                 0.0015 
                 0.0272 
                 0.0376 
                 0.2039 
                 0.1616 
                 0.5562 
               
               
                 312 
                 0.5547 
                 0.4482 
                 0.1987 
                 0.3759 
                 0.4748 
                 0.7453 
               
               
                 318 
                 0.8247 
                 0.5300 
                 0.6009 
                 0.5693 
                 0.7619 
                 0.8380 
               
               
                 321 
                 0.0378 
                 0.1538 
                 0.1191 
                 0.3026 
                 0.5578 
                 0.7770 
               
               
                 323 
                 0.6526 
                 0.4749 
                 0.9420 
                 0.6284 
                 0.7055 
                 0.8380 
               
               
                 326 
                 0.9918 
                 0.5795 
                 0.3433 
                 0.4761 
                 0.3484 
                 0.7016 
               
               
                 328 
                 0.6245 
                 0.4679 
                 0.0968 
                 0.2845 
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                 332 
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                 333 
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                 334 
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                 337 
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                 342 
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                 343 
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                 349 
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                 351 
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                 353 
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                 362 
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                 363 
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                 364 
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                 365 
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                 367 
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                 369 
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                 372 
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                 373 
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                 375 
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                 382 
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                 383 
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                 386 
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                 387 
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                 392 
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                 397 
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                 399 
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                 405 
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                 410 
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                 411 
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                 412 
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                 418 
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                 421 
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                 426 
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                 429 
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                 430 
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                 436 
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                 438 
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                 439 
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                 442 
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                 443 
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                 445 
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                 446 
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                 447 
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                 451 
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                 456 
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                 459 
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                 460 
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                 461 
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                 465 
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                 467 
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                 468 
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                 469 
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                 471 
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                 472 
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                 473 
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                 474 
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                 475 
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                 476 
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                 477 
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                 478 
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                 479 
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                 480 
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                 756 
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                 929 
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                 955 
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                 958 
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                 959 
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                 965 
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                 967 
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                 972 
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                 973 
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                 974 
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                 975 
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                 978 
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                 981 
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                 982 
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                 983 
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                 984 
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                 986 
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                 993 
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                 994 
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                 995 
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                 997 
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                 1018 
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                 1020 
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                 1023 
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                 1024 
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                 1028 
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                 1030 
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                 1033 
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                 1073 
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                 1078 
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                 1079 
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                 1080 
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                 1090 
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                 1099 
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                 1104 
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                 1108 
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                 1109 
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                 1111 
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                 1115 
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                 1116 
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                 1123 
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                 1127 
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                 1131 
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                 1132 
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                 1138 
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                 1149 
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                 1150 
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                 1152 
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                 1157 
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                 1163 
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                 1165 
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                 1166 
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                 1167 
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                 1169 
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                 1179 
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                 1181 
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                 1183 
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                 1201 
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                 1203 
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                 1204 
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                 1205 
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                 1217 
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                 1218 
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                 1223 
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                 1225 
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                 1236 
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                 1239 
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                 1244 
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                 1247 
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                 1253 
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                 1258 
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                 1259 
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                 1260 
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                 1264 
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                 1265 
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                 1267 
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                 1269 
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                 1270 
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                 1271 
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                 1272 
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                 1273 
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                 1274 
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                 1276 
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                 1277 
                 0.2702 
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                 1351 
                 0.0246 
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                 1355 
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                 1359 
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                 1360 
                 0.7865 
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                 1363 
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                 1372 
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                 1430 
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                 1446 
                 0.0908 
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                 1449 
                 0.4880 
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                 1452 
                 0.0057 
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                 1480 
                 0.0876 
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                 1482 
                 0.8932 
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                 0.1623 
                 0.5562 
               
               
                 1483 
                 0.5727 
                 0.4527 
                 0.9634 
                 0.6339 
                 0.5422 
                 0.7770 
               
               
                 1485 
                 0.0448 
                 0.1640 
                 0.0022 
                 0.0478 
                 0.1862 
                 0.5850 
               
               
                 1487 
                 0.3523 
                 0.3477 
                 0.5522 
                 0.5606 
                 0.7317 
                 0.8380 
               
               
                 1488 
                 0.0481 
                 0.1705 
                 0.0145 
                 0.1190 
                 0.5732 
                 0.7827 
               
               
                 1495 
                 0.0265 
                 0.1275 
                 0.0006 
                 0.0251 
                 0.1077 
                 0.5131 
               
               
                 1496 
                 0.0027 
                 0.0354 
                 0.0032 
                 0.0542 
                 0.9359 
                 0.8691 
               
               
                 1498 
                 0.0049 
                 0.0517 
                 0.0313 
                 0.1861 
                 0.4069 
                 0.7283 
               
               
                 1499 
                 0.0012 
                 0.0250 
                 0.0002 
                 0.0150 
                 0.4594 
                 0.7415 
               
               
                 1500 
                 0.0120 
                 0.0774 
                 0.1777 
                 0.3736 
                 0.1868 
                 0.5850 
               
               
                 1501 
                 0.0060 
                 0.0536 
                 0.0000 
                 0.0068 
                 0.0398 
                 0.3434 
               
               
                 1503 
                 0.1279 
                 0.2311 
                 0.0034 
                 0.0550 
                 0.0992 
                 0.5102 
               
               
                 1504 
                 0.0042 
                 0.0494 
                 0.0007 
                 0.0251 
                 0.4521 
                 0.7415 
               
               
                 1506 
                 0.0071 
                 0.0583 
                 0.0002 
                 0.0150 
                 0.1233 
                 0.5308 
               
               
                 1517 
                 0.0021 
                 0.0325 
                 0.3098 
                 0.4633 
                 0.0216 
                 0.2516 
               
               
                 1518 
                 0.2135 
                 0.2800 
                 0.1219 
                 0.3029 
                 0.7443 
                 0.8380 
               
               
                 1519 
                 0.1253 
                 0.2311 
                 0.0672 
                 0.2508 
                 0.7404 
                 0.8380 
               
               
                 1521 
                 0.9421 
                 0.5646 
                 0.7271 
                 0.5835 
                 0.7821 
                 0.8418 
               
               
                 1522 
                 0.0752 
                 0.2002 
                 0.0032 
                 0.0542 
                 0.1574 
                 0.5562 
               
               
                 1523 
                 0.0186 
                 0.0987 
                 0.0112 
                 0.1024 
                 0.8197 
                 0.8519 
               
               
                 1524 
                 0.0012 
                 0.0250 
                 0.0541 
                 0.2376 
                 0.1008 
                 0.5102 
               
               
                 1527 
                 0.6329 
                 0.4691 
                 0.7653 
                 0.5937 
                 0.8571 
                 0.8610 
               
               
                 1528 
                 0.9839 
                 0.5782 
                 0.3664 
                 0.4776 
                 0.3561 
                 0.7016 
               
               
                 1529 
                 0.9418 
                 0.5646 
                 0.9150 
                 0.6254 
                 0.8574 
                 0.8610 
               
               
                 1536 
                 0.2549 
                 0.2999 
                 0.0457 
                 0.2206 
                 0.3492 
                 0.7016 
               
               
                 1537 
                 0.3395 
                 0.3473 
                 0.8190 
                 0.6041 
                 0.4640 
                 0.7418 
               
               
                 1539 
                 0.6187 
                 0.4657 
                 0.0239 
                 0.1518 
                 0.0079 
                 0.1319 
               
               
                 1541 
                 0.3704 
                 0.3613 
                 0.6673 
                 0.5775 
                 0.6364 
                 0.8251 
               
               
                 1542 
                 0.3291 
                 0.3473 
                 0.3550 
                 0.4766 
                 0.9579 
                 0.8691 
               
               
                 1547 
                 0.5510 
                 0.4474 
                 0.0349 
                 0.1980 
                 0.0095 
                 0.1438 
               
               
                 1565 
                 0.0995 
                 0.2247 
                 0.1886 
                 0.3753 
                 0.7181 
                 0.8380 
               
               
                 1567 
                 0.0514 
                 0.1713 
                 0.1082 
                 0.2848 
                 0.7006 
                 0.8380 
               
               
                 1582 
                 0.6160 
                 0.4647 
                 0.9628 
                 0.6339 
                 0.6489 
                 0.8251 
               
               
                 1711 
                 0.2539 
                 0.2999 
                 0.5787 
                 0.5622 
                 0.5486 
                 0.7770 
               
               
                 1718 
                 0.5919 
                 0.4576 
                 0.1954 
                 0.3759 
                 0.4361 
                 0.7283 
               
               
                 1721 
                 0.1512 
                 0.2443 
                 0.6197 
                 0.5695 
                 0.3348 
                 0.6976 
               
               
                 1731 
                 0.9262 
                 0.5621 
                 0.9144 
                 0.6254 
                 0.9881 
                 0.8795 
               
               
                 1732 
                 0.4243 
                 0.3886 
                 0.4206 
                 0.5036 
                 0.9947 
                 0.8795 
               
               
                 1744 
                 0.5087 
                 0.4333 
                 0.5348 
                 0.5566 
                 0.9676 
                 0.8695 
               
               
                 1753 
                 0.2935 
                 0.3257 
                 0.5427 
                 0.5598 
                 0.1050 
                 0.5131 
               
               
                 1754 
                 0.0014 
                 0.0272 
                 0.4012 
                 0.4995 
                 0.0100 
                 0.1466 
               
               
                 1782 
                 0.0594 
                 0.1764 
                 0.1090 
                 0.2848 
                 0.7514 
                 0.8380 
               
               
                 1783 
                 0.5924 
                 0.4576 
                 0.7553 
                 0.5925 
                 0.3999 
                 0.7283 
               
               
                 1784 
                 0.0174 
                 0.0987 
                 0.2076 
                 0.3788 
                 0.2118 
                 0.6023 
               
               
                 1786 
                 0.0000 
                 0.0007 
                 0.0004 
                 0.0215 
                 0.1142 
                 0.5146 
               
               
                 1788 
                 0.2512 
                 0.2999 
                 0.7611 
                 0.5929 
                 0.1518 
                 0.5562 
               
               
                 1789 
                 0.2869 
                 0.3217 
                 0.7359 
                 0.5835 
                 0.4608 
                 0.7415 
               
               
                 1790 
                 0.0089 
                 0.0665 
                 0.1755 
                 0.3736 
                 0.1507 
                 0.5562 
               
               
                 1791 
                 0.8874 
                 0.5563 
                 0.3204 
                 0.4661 
                 0.2587 
                 0.6316 
               
               
                 1792 
                 0.5911 
                 0.4576 
                 0.0275 
                 0.1661 
                 0.0819 
                 0.4886 
               
               
                 1793 
                 0.0000 
                 0.0008 
                 0.0089 
                 0.0919 
                 0.0000 
                 0.0000 
               
               
                 1811 
                 0.2616 
                 0.3026 
                 0.8182 
                 0.6041 
                 0.1804 
                 0.5850 
               
               
                 1815 
                 0.6708 
                 0.4860 
                 0.8005 
                 0.6041 
                 0.8626 
                 0.8610 
               
               
                 1827 
                 0.2900 
                 0.3230 
                 0.6911 
                 0.5790 
                 0.5020 
                 0.7580 
               
               
                 1828 
                 0.5922 
                 0.4576 
                 0.5475 
                 0.5606 
                 0.2612 
                 0.6345 
               
               
                 1829 
                 0.0363 
                 0.1496 
                 0.3586 
                 0.4766 
                 0.2069 
                 0.5984 
               
               
                 1831 
                 0.3354 
                 0.3473 
                 0.8571 
                 0.6114 
                 0.4304 
                 0.7283 
               
               
                 1834 
                 0.1364 
                 0.2318 
                 0.9269 
                 0.6282 
                 0.1602 
                 0.5562 
               
               
                 1837 
                 0.2408 
                 0.2964 
                 0.7994 
                 0.6041 
                 0.1581 
                 0.5562 
               
               
                 1841 
                 0.0260 
                 0.1275 
                 0.4799 
                 0.5295 
                 0.1075 
                 0.5131 
               
               
                 1845 
                 0.2742 
                 0.3117 
                 0.7228 
                 0.5835 
                 0.4534 
                 0.7415 
               
               
                 1851 
                 0.7175 
                 0.4958 
                 0.1004 
                 0.2848 
                 0.1904 
                 0.5863 
               
               
                 1866 
                 0.4976 
                 0.4305 
                 0.2195 
                 0.3875 
                 0.0643 
                 0.4168 
               
               
                 1867 
                 0.5923 
                 0.4576 
                 0.3013 
                 0.4575 
                 0.1241 
                 0.5308 
               
               
                 1870 
                 0.1911 
                 0.2658 
                 0.5162 
                 0.5450 
                 0.0577 
                 0.4034 
               
               
                 1878 
                 0.5989 
                 0.4592 
                 0.3385 
                 0.4761 
                 0.1454 
                 0.5562 
               
               
                 1884 
                 0.5446 
                 0.4466 
                 0.0735 
                 0.2580 
                 0.2178 
                 0.6063 
               
               
                 1889 
                 0.4130 
                 0.3838 
                 0.0684 
                 0.2522 
                 0.2887 
                 0.6507 
               
               
                 1892 
                 0.0105 
                 0.0719 
                 0.7495 
                 0.5914 
                 0.0051 
                 0.1021 
               
               
                 1902 
                 0.2507 
                 0.2999 
                 0.0530 
                 0.2376 
                 0.3927 
                 0.7252 
               
               
                 1903 
                 0.0020 
                 0.0325 
                 0.9348 
                 0.6284 
                 0.0024 
                 0.0680 
               
               
                 1907 
                 0.1561 
                 0.2443 
                 0.8592 
                 0.6114 
                 0.2104 
                 0.6023 
               
               
                 1945 
                 0.9674 
                 0.5743 
                 0.4211 
                 0.5036 
                 0.4446 
                 0.7345 
               
               
                 1948 
                 0.2513 
                 0.2999 
                 0.7634 
                 0.5935 
                 0.1528 
                 0.5562 
               
               
                 1949 
                 0.5600 
                 0.4491 
                 0.1070 
                 0.2848 
                 0.2865 
                 0.6507 
               
               
                 1950 
                 0.0497 
                 0.1713 
                 0.2671 
                 0.4245 
                 0.3546 
                 0.7016 
               
               
                 1953 
                 0.3117 
                 0.3380 
                 0.4666 
                 0.5230 
                 0.7705 
                 0.8418 
               
               
                 1955 
                 0.3568 
                 0.3511 
                 0.0674 
                 0.2508 
                 0.3336 
                 0.6976 
               
               
                 1962 
                 0.9114 
                 0.5574 
                 0.1815 
                 0.3746 
                 0.2181 
                 0.6063 
               
               
                 1970 
                 0.4974 
                 0.4305 
                 0.1732 
                 0.3733 
                 0.4791 
                 0.7453 
               
               
                 1974 
                 0.3480 
                 0.3474 
                 0.0505 
                 0.2355 
                 0.2760 
                 0.6423 
               
               
                 1975 
                 0.1455 
                 0.2422 
                 0.2588 
                 0.4219 
                 0.7282 
                 0.8380 
               
               
                 1976 
                 0.0216 
                 0.1120 
                 0.4143 
                 0.5036 
                 0.1128 
                 0.5146 
               
               
                 1979 
                 0.1612 
                 0.2443 
                 0.3770 
                 0.4841 
                 0.5873 
                 0.7858 
               
               
                 1982 
                 0.3398 
                 0.3473 
                 0.1021 
                 0.2848 
                 0.4705 
                 0.7431 
               
               
                 1985 
                 0.0467 
                 0.1693 
                 0.5029 
                 0.5402 
                 0.1661 
                 0.5616 
               
               
                 2016 
                 0.6755 
                 0.4870 
                 0.8330 
                 0.6041 
                 0.8348 
                 0.8578 
               
               
                 2021 
                 0.9932 
                 0.5795 
                 0.6421 
                 0.5695 
                 0.6482 
                 0.8251 
               
               
                 2024 
                 0.5150 
                 0.4340 
                 0.4712 
                 0.5230 
                 0.9437 
                 0.8691 
               
               
                 2034 
                 0.1335 
                 0.2311 
                 0.9181 
                 0.6254 
                 0.1599 
                 0.5562 
               
               
                 2052 
                 0.5201 
                 0.4340 
                 0.1615 
                 0.3616 
                 0.4337 
                 0.7283 
               
               
                 2067 
                 0.6403 
                 0.4711 
                 0.3621 
                 0.4766 
                 0.6517 
                 0.8251 
               
               
                 2072 
                 0.1572 
                 0.2443 
                 0.1039 
                 0.2848 
                 0.8171 
                 0.8519 
               
               
                 2105 
                 0.1672 
                 0.2483 
                 0.7675 
                 0.5941 
                 0.2704 
                 0.6409 
               
               
                 2106 
                 0.0634 
                 0.1838 
                 0.3699 
                 0.4799 
                 0.3070 
                 0.6785 
               
               
                 2107 
                 0.1812 
                 0.2616 
                 0.5744 
                 0.5622 
                 0.4250 
                 0.7283 
               
               
                 2113 
                 0.1153 
                 0.2311 
                 0.4629 
                 0.5230 
                 0.3799 
                 0.7228 
               
               
                 2115 
                 0.1968 
                 0.2703 
                 0.8429 
                 0.6055 
                 0.2700 
                 0.6409 
               
               
                 2118 
                 0.9029 
                 0.5563 
                 0.4954 
                 0.5353 
                 0.4230 
                 0.7283 
               
               
                 2136 
                 0.7034 
                 0.4913 
                 0.4358 
                 0.5066 
                 0.6869 
                 0.8380 
               
               
                 2157 
                 0.1619 
                 0.2443 
                 0.6697 
                 0.5775 
                 0.3201 
                 0.6817 
               
               
                 2164 
                 0.3501 
                 0.3476 
                 0.6313 
                 0.5695 
                 0.1642 
                 0.5589 
               
               
                 2165 
                 0.5508 
                 0.4474 
                 0.6280 
                 0.5695 
                 0.9098 
                 0.8681 
               
               
                 2166 
                 0.2437 
                 0.2964 
                 0.6778 
                 0.5782 
                 0.4447 
                 0.7345 
               
               
                 2168 
                 0.8103 
                 0.5274 
                 0.3486 
                 0.4761 
                 0.4818 
                 0.7453 
               
               
                 2179 
                 0.1591 
                 0.2443 
                 0.2351 
                 0.3921 
                 0.8139 
                 0.8519 
               
               
                 2192 
                 0.2607 
                 0.3026 
                 0.3177 
                 0.4661 
                 0.8957 
                 0.8681 
               
               
                 2193 
                 0.0433 
                 0.1640 
                 0.1861 
                 0.3748 
                 0.4394 
                 0.7305 
               
               
                 2194 
                 0.8745 
                 0.5533 
                 0.7578 
                 0.5929 
                 0.6416 
                 0.8251 
               
               
                 2199 
                 0.2222 
                 0.2893 
                 0.0840 
                 0.2676 
                 0.5829 
                 0.7858 
               
               
                 2203 
                 0.2282 
                 0.2893 
                 0.4013 
                 0.4995 
                 0.7039 
                 0.8380 
               
               
                 2206 
                 0.7021 
                 0.4913 
                 0.6515 
                 0.5695 
                 0.4072 
                 0.7283 
               
               
                 2209 
                 0.7281 
                 0.5004 
                 0.6080 
                 0.5695 
                 0.3927 
                 0.7252 
               
               
                 2211 
                 0.3753 
                 0.3628 
                 0.7981 
                 0.6041 
                 0.5246 
                 0.7740 
               
               
                 2217 
                 0.0942 
                 0.2167 
                 0.0646 
                 0.2508 
                 0.8445 
                 0.8610 
               
               
                 2310 
                 0.1841 
                 0.2616 
                 0.1950 
                 0.3759 
                 0.9724 
                 0.8705 
               
               
                 2311 
                 0.0447 
                 0.1640 
                 0.2344 
                 0.3921 
                 0.3707 
                 0.7146 
               
               
                 2312 
                 0.5323 
                 0.4420 
                 0.2612 
                 0.4221 
                 0.0883 
                 0.4997 
               
               
                 2313 
                 0.5651 
                 0.4500 
                 0.6088 
                 0.5695 
                 0.2823 
                 0.6480 
               
               
                 2314 
                 0.1623 
                 0.2443 
                 0.3326 
                 0.4750 
                 0.6520 
                 0.8251 
               
               
                 2318 
                 0.2100 
                 0.2772 
                 0.1137 
                 0.2931 
                 0.7236 
                 0.8380 
               
               
                 2327 
                 0.2886 
                 0.3225 
                 0.3721 
                 0.4811 
                 0.8613 
                 0.8610 
               
               
                 2343 
                 0.7723 
                 0.5212 
                 0.2678 
                 0.4245 
                 0.1673 
                 0.5618 
               
               
                 2345 
                 0.2277 
                 0.2893 
                 0.0415 
                 0.2154 
                 0.3614 
                 0.7037 
               
               
                 2347 
                 0.9766 
                 0.5766 
                 0.0877 
                 0.2729 
                 0.0927 
                 0.5044 
               
               
                 2348 
                 0.1321 
                 0.2311 
                 0.2274 
                 0.3879 
                 0.7487 
                 0.8380 
               
               
                 2350 
                 0.9394 
                 0.5646 
                 0.8270 
                 0.6041 
                 0.7685 
                 0.8418 
               
               
                 2351 
                 0.0549 
                 0.1757 
                 0.1667 
                 0.3679 
                 0.5529 
                 0.7770 
               
               
                 2356 
                 0.3408 
                 0.3473 
                 0.2658 
                 0.4245 
                 0.8675 
                 0.8610 
               
               
                 2357 
                 0.5479 
                 0.4474 
                 0.8603 
                 0.6114 
                 0.6696 
                 0.8314 
               
               
                 2360 
                 0.6340 
                 0.4691 
                 0.6009 
                 0.5693 
                 0.9622 
                 0.8691 
               
               
                 2361 
                 0.4778 
                 0.4222 
                 0.7888 
                 0.6001 
                 0.6561 
                 0.8251 
               
               
                 2364 
                 0.4396 
                 0.3992 
                 0.6469 
                 0.5695 
                 0.7497 
                 0.8380 
               
               
                 2371 
                 0.1537 
                 0.2443 
                 0.8214 
                 0.6041 
                 0.2242 
                 0.6097 
               
               
                 2374 
                 0.0871 
                 0.2155 
                 0.3760 
                 0.4841 
                 0.3822 
                 0.7245 
               
               
                 2375 
                 0.7645 
                 0.5185 
                 0.8326 
                 0.6041 
                 0.9295 
                 0.8691 
               
               
                 2376 
                 0.8157 
                 0.5274 
                 0.7779 
                 0.5988 
                 0.9608 
                 0.8691 
               
               
                 2379 
                 0.9018 
                 0.5563 
                 0.5705 
                 0.5622 
                 0.6562 
                 0.8251 
               
               
                 2381 
                 0.4894 
                 0.4290 
                 0.5093 
                 0.5413 
                 0.1840 
                 0.5850 
               
               
                 2383 
                 0.1840 
                 0.2616 
                 0.3225 
                 0.4661 
                 0.7214 
                 0.8380 
               
               
                 2394 
                 0.1243 
                 0.2311 
                 0.2913 
                 0.4492 
                 0.6084 
                 0.8054 
               
               
                 2395 
                 0.0130 
                 0.0808 
                 0.6430 
                 0.5695 
                 0.0354 
                 0.3175 
               
               
                 2407 
                 0.9444 
                 0.5650 
                 0.4218 
                 0.5036 
                 0.4623 
                 0.7415 
               
               
                 2411 
                 0.8949 
                 0.5563 
                 0.6834 
                 0.5790 
                 0.7823 
                 0.8418 
               
               
                 2413 
                 0.0095 
                 0.0696 
                 0.1895 
                 0.3753 
                 0.1468 
                 0.5562 
               
               
                 2416 
                 0.2734 
                 0.3117 
                 0.4735 
                 0.5240 
                 0.6964 
                 0.8380 
               
               
                 2418 
                 0.0128 
                 0.0808 
                 0.5694 
                 0.5622 
                 0.0435 
                 0.3453 
               
               
                 2419 
                 0.1246 
                 0.2311 
                 0.0914 
                 0.2784 
                 0.8665 
                 0.8610 
               
               
                 2420 
                 0.5868 
                 0.4576 
                 0.4232 
                 0.5036 
                 0.7935 
                 0.8449 
               
               
                 2422 
                 0.0734 
                 0.2002 
                 0.0104 
                 0.1024 
                 0.3603 
                 0.7037 
               
               
                 2423 
                 0.1282 
                 0.2311 
                 0.0007 
                 0.0251 
                 0.0270 
                 0.2876 
               
               
                 2426 
                 0.0076 
                 0.0609 
                 0.1055 
                 0.2848 
                 0.2171 
                 0.6063 
               
               
                 2429 
                 0.6126 
                 0.4643 
                 0.4182 
                 0.5036 
                 0.7580 
                 0.8380 
               
               
                 2431 
                 0.1221 
                 0.2311 
                 0.3934 
                 0.4991 
                 0.4665 
                 0.7420 
               
               
                 2432 
                 0.0181 
                 0.0987 
                 0.3080 
                 0.4633 
                 0.1423 
                 0.5562 
               
               
                 2442 
                 0.2232 
                 0.2893 
                 0.9776 
                 0.6396 
                 0.2334 
                 0.6153 
               
               
                 2443 
                 0.6514 
                 0.4749 
                 0.9108 
                 0.6254 
                 0.5737 
                 0.7827 
               
               
                 2445 
                 0.2344 
                 0.2947 
                 0.2646 
                 0.4245 
                 0.9384 
                 0.8691 
               
               
                 2448 
                 0.9076 
                 0.5571 
                 0.0461 
                 0.2206 
                 0.0582 
                 0.4034 
               
               
                 2449 
                 0.5356 
                 0.4425 
                 0.0595 
                 0.2435 
                 0.1866 
                 0.5850 
               
               
                 2474 
                 0.8804 
                 0.5560 
                 0.6482 
                 0.5695 
                 0.5452 
                 0.7770 
               
               
                 2480 
                 0.3736 
                 0.3623 
                 0.0830 
                 0.2676 
                 0.3713 
                 0.7146 
               
               
                 2481 
                 0.5681 
                 0.4508 
                 0.0567 
                 0.2376 
                 0.0170 
                 0.2130 
               
               
                 2488 
                 0.1556 
                 0.2443 
                 0.0031 
                 0.0542 
                 0.0738 
                 0.4614 
               
               
                 2491 
                 0.3989 
                 0.3757 
                 0.4702 
                 0.5230 
                 0.1257 
                 0.5309 
               
               
                 2493 
                 0.7144 
                 0.4948 
                 0.3117 
                 0.4633 
                 0.1742 
                 0.5773 
               
               
                 2498 
                 0.5980 
                 0.4592 
                 0.2048 
                 0.3759 
                 0.0796 
                 0.4860 
               
               
                 2499 
                 0.9211 
                 0.5621 
                 0.6360 
                 0.5695 
                 0.7077 
                 0.8380 
               
               
                 2513 
                 0.0751 
                 0.2002 
                 0.0559 
                 0.2376 
                 0.8802 
                 0.8620 
               
               
                 2514 
                 0.3463 
                 0.3473 
                 0.3045 
                 0.4599 
                 0.0572 
                 0.4034 
               
               
                 2517 
                 0.5486 
                 0.4474 
                 0.0832 
                 0.2676 
                 0.2391 
                 0.6213 
               
               
                 2518 
                 0.3423 
                 0.3473 
                 0.6378 
                 0.5695 
                 0.6262 
                 0.8182 
               
               
                 2520 
                 0.4220 
                 0.3875 
                 0.7001 
                 0.5811 
                 0.6725 
                 0.8315 
               
               
                 2522 
                 0.3457 
                 0.3473 
                 0.8662 
                 0.6127 
                 0.2692 
                 0.6409 
               
               
                 2523 
                 0.9294 
                 0.5621 
                 0.5386 
                 0.5590 
                 0.4826 
                 0.7453 
               
               
                 2525 
                 0.9111 
                 0.5574 
                 0.4665 
                 0.5230 
                 0.4024 
                 0.7283 
               
               
                 2543 
                 0.6767 
                 0.4870 
                 0.9625 
                 0.6339 
                 0.7112 
                 0.8380 
               
               
                 2547 
                 0.1665 
                 0.2483 
                 0.5764 
                 0.5622 
                 0.0588 
                 0.4034 
               
               
                 2549 
                 0.6467 
                 0.4737 
                 0.0817 
                 0.2676 
                 0.1866 
                 0.5850 
               
               
                 2561 
                 0.8192 
                 0.5274 
                 0.9742 
                 0.6388 
                 0.8444 
                 0.8610 
               
               
                 2563 
                 0.1241 
                 0.2311 
                 0.9291 
                 0.6282 
                 0.1453 
                 0.5562 
               
               
                 2564 
                 0.3928 
                 0.3742 
                 0.7265 
                 0.5835 
                 0.2336 
                 0.6153 
               
               
                 2565 
                 0.3303 
                 0.3473 
                 0.2933 
                 0.4503 
                 0.9358 
                 0.8691 
               
               
                 2566 
                 0.8272 
                 0.5305 
                 0.5797 
                 0.5622 
                 0.7361 
                 0.8380 
               
               
                 2567 
                 0.0922 
                 0.2167 
                 0.9478 
                 0.6291 
                 0.1042 
                 0.5131 
               
               
                 2568 
                 0.1188 
                 0.2311 
                 0.5943 
                 0.5688 
                 0.0421 
                 0.3453 
               
               
                 2569 
                 0.7019 
                 0.4913 
                 0.3509 
                 0.4761 
                 0.5772 
                 0.7827 
               
               
                 2570 
                 0.0943 
                 0.2167 
                 0.3472 
                 0.4761 
                 0.4366 
                 0.7283 
               
               
                 2575 
                 0.5220 
                 0.4345 
                 0.3582 
                 0.4766 
                 0.7757 
                 0.8418 
               
               
                 2577 
                 0.2102 
                 0.2772 
                 0.4688 
                 0.5230 
                 0.5844 
                 0.7858 
               
               
                 2579 
                 0.4349 
                 0.3960 
                 0.2238 
                 0.3875 
                 0.6515 
                 0.8251 
               
               
                 2580 
                 0.0542 
                 0.1757 
                 0.4499 
                 0.5197 
                 0.2169 
                 0.6063 
               
               
                 2581 
                 0.1288 
                 0.2311 
                 0.4892 
                 0.5349 
                 0.3895 
                 0.7252 
               
               
                 2583 
                 0.0863 
                 0.2155 
                 0.9790 
                 0.6396 
                 0.0907 
                 0.5044 
               
               
                 2588 
                 0.2704 
                 0.3106 
                 0.6243 
                 0.5695 
                 0.5320 
                 0.7770 
               
               
                 2591 
                 0.1471 
                 0.2433 
                 0.4643 
                 0.5230 
                 0.0355 
                 0.3175 
               
               
                 2592 
                 0.7752 
                 0.5212 
                 0.0881 
                 0.2729 
                 0.0504 
                 0.3818 
               
               
                 2594 
                 0.6856 
                 0.4905 
                 0.8129 
                 0.6041 
                 0.5226 
                 0.7738 
               
               
                 2610 
                 0.0753 
                 0.2002 
                 0.6346 
                 0.5695 
                 0.1788 
                 0.5847 
               
               
                 2624 
                 0.1982 
                 0.2712 
                 0.6000 
                 0.5693 
                 0.0771 
                 0.4764 
               
               
                 2625 
                 0.4206 
                 0.3872 
                 0.5346 
                 0.5566 
                 0.1614 
                 0.5562 
               
               
                 2649 
                 0.0059 
                 0.0536 
                 0.0562 
                 0.2376 
                 0.3034 
                 0.6748 
               
               
                 2652 
                 0.5148 
                 0.4340 
                 0.2860 
                 0.4447 
                 0.0938 
                 0.5048 
               
               
                 2669 
                 0.0280 
                 0.1320 
                 0.1059 
                 0.2848 
                 0.5070 
                 0.7596 
               
               
                 3453 
                 0.6988 
                 0.4913 
                 0.2050 
                 0.3759 
                 0.3697 
                 0.7146 
               
               
                 3454 
                 0.9582 
                 0.5712 
                 0.1073 
                 0.2848 
                 0.1181 
                 0.5242 
               
               
                 3455 
                 0.8397 
                 0.5354 
                 0.0643 
                 0.2508 
                 0.0428 
                 0.3453 
               
               
                 3456 
                 0.4812 
                 0.4241 
                 0.1233 
                 0.3029 
                 0.0306 
                 0.2992 
               
               
                 3458 
                 0.0267 
                 0.1275 
                 0.0016 
                 0.0422 
                 0.2238 
                 0.6097 
               
               
                 3461 
                 0.1794 
                 0.2616 
                 0.7325 
                 0.5835 
                 0.3086 
                 0.6785 
               
               
                 3462 
                 0.7023 
                 0.4913 
                 0.0904 
                 0.2777 
                 0.0425 
                 0.3453 
               
               
                 3464 
                 0.0047 
                 0.0517 
                 0.0841 
                 0.2676 
                 0.1882 
                 0.5850 
               
               
                 3466 
                 0.2729 
                 0.3117 
                 0.5765 
                 0.5622 
                 0.1056 
                 0.5131 
               
               
                 3471 
                 0.0565 
                 0.1757 
                 0.0212 
                 0.1420 
                 0.6393 
                 0.8251 
               
               
                 3472 
                 0.7507 
                 0.5113 
                 0.2731 
                 0.4282 
                 0.4303 
                 0.7283 
               
               
                 3473 
                 0.0162 
                 0.0939 
                 0.3477 
                 0.4761 
                 0.1119 
                 0.5146 
               
               
                 3474 
                 0.0016 
                 0.0282 
                 0.0172 
                 0.1295 
                 0.3091 
                 0.6785 
               
               
                 3478 
                 0.7286 
                 0.5004 
                 0.3977 
                 0.4995 
                 0.6140 
                 0.8107 
               
               
                 3479 
                 0.8920 
                 0.5563 
                 0.0659 
                 0.2508 
                 0.0503 
                 0.3818 
               
               
                 3480 
                 0.5085 
                 0.4333 
                 0.8352 
                 0.6041 
                 0.6488 
                 0.8251 
               
               
                 3485 
                 0.3407 
                 0.3473 
                 0.8628 
                 0.6114 
                 0.2632 
                 0.6364 
               
               
                 3495 
                 0.1476 
                 0.2433 
                 0.9375 
                 0.6284 
                 0.1285 
                 0.5309 
               
               
                 3498 
                 0.3963 
                 0.3754 
                 0.8121 
                 0.6041 
                 0.5384 
                 0.7770 
               
               
                 3505 
                 0.4588 
                 0.4111 
                 0.1039 
                 0.2848 
                 0.3543 
                 0.7016 
               
               
                 3507 
                 0.3431 
                 0.3473 
                 0.7293 
                 0.5835 
                 0.5422 
                 0.7770 
               
               
                 3508 
                 0.1538 
                 0.2443 
                 0.0806 
                 0.2676 
                 0.7243 
                 0.8380 
               
               
                 3513 
                 0.1333 
                 0.2311 
                 0.1841 
                 0.3746 
                 0.8522 
                 0.8610 
               
               
                 3514 
                 0.1222 
                 0.2311 
                 0.2607 
                 0.4221 
                 0.6530 
                 0.8251 
               
               
                 3516 
                 0.5175 
                 0.4340 
                 0.9399 
                 0.6284 
                 0.4708 
                 0.7431 
               
               
                 3522 
                 0.1013 
                 0.2257 
                 0.3453 
                 0.4761 
                 0.4614 
                 0.7415 
               
               
                 3528 
                 0.4692 
                 0.4181 
                 0.4296 
                 0.5036 
                 0.1383 
                 0.5562 
               
               
                 3530 
                 0.8917 
                 0.5563 
                 0.6426 
                 0.5695 
                 0.7424 
                 0.8380 
               
               
                 3533 
                 0.7342 
                 0.5011 
                 0.0145 
                 0.1190 
                 0.0303 
                 0.2992 
               
               
                 3534 
                 0.7285 
                 0.5004 
                 0.0019 
                 0.0462 
                 0.0042 
                 0.0925 
               
               
                 3535 
                 0.1140 
                 0.2311 
                 0.2034 
                 0.3759 
                 0.7393 
                 0.8380 
               
               
                 3537 
                 0.7091 
                 0.4932 
                 0.6344 
                 0.5695 
                 0.9177 
                 0.8691 
               
               
                 3541 
                 0.2248 
                 0.2893 
                 0.1794 
                 0.3736 
                 0.8911 
                 0.8658 
               
               
                 3542 
                 0.8063 
                 0.5274 
                 0.2310 
                 0.3905 
                 0.1534 
                 0.5562 
               
               
                 3547 
                 0.3238 
                 0.3458 
                 0.0066 
                 0.0842 
                 0.0572 
                 0.4034 
               
               
                 3548 
                 0.0742 
                 0.2002 
                 0.0070 
                 0.0854 
                 0.2742 
                 0.6411 
               
               
                 3549 
                 0.0183 
                 0.0987 
                 0.4057 
                 0.5016 
                 0.1008 
                 0.5102 
               
               
                 3550 
                 0.0631 
                 0.1838 
                 0.8948 
                 0.6233 
                 0.0484 
                 0.3787 
               
               
                 3552 
                 0.1138 
                 0.2311 
                 0.1875 
                 0.3753 
                 0.0068 
                 0.1213 
               
               
                 3563 
                 0.0294 
                 0.1325 
                 0.6125 
                 0.5695 
                 0.0820 
                 0.4886 
               
               
                 3565 
                 0.5592 
                 0.4491 
                 0.8370 
                 0.6041 
                 0.7038 
                 0.8380 
               
               
                 3566 
                 0.1183 
                 0.2311 
                 0.7143 
                 0.5835 
                 0.0588 
                 0.4034 
               
               
                 3567 
                 0.1998 
                 0.2715 
                 0.8892 
                 0.6233 
                 0.2500 
                 0.6228 
               
               
                 3568 
                 0.6043 
                 0.4610 
                 0.0084 
                 0.0919 
                 0.0265 
                 0.2876 
               
               
                 3572 
                 0.1181 
                 0.2311 
                 0.2684 
                 0.4245 
                 0.6263 
                 0.8182 
               
               
                 3573 
                 0.3454 
                 0.3473 
                 0.4205 
                 0.5036 
                 0.0888 
                 0.4997 
               
               
                 3576 
                 0.6347 
                 0.4691 
                 0.9016 
                 0.6245 
                 0.7246 
                 0.8380 
               
               
                 3577 
                 0.1196 
                 0.2311 
                 0.0177 
                 0.1305 
                 0.3492 
                 0.7016 
               
               
                 3578 
                 0.7635 
                 0.5185 
                 0.3616 
                 0.4766 
                 0.2298 
                 0.6153 
               
               
                 3579 
                 0.9242 
                 0.5621 
                 0.6417 
                 0.5695 
                 0.5758 
                 0.7827 
               
               
                 3580 
                 0.3075 
                 0.3362 
                 0.7120 
                 0.5835 
                 0.5088 
                 0.7600 
               
               
                 3585 
                 0.0947 
                 0.2167 
                 0.6588 
                 0.5739 
                 0.2063 
                 0.5984 
               
               
                 3587 
                 0.0564 
                 0.1757 
                 0.0088 
                 0.0919 
                 0.3910 
                 0.7252 
               
               
                 3588 
                 0.2554 
                 0.2999 
                 0.8628 
                 0.6114 
                 0.1933 
                 0.5864 
               
               
                 3589 
                 0.3985 
                 0.3757 
                 0.8302 
                 0.6041 
                 0.5259 
                 0.7740 
               
               
                 3598 
                 0.3169 
                 0.3414 
                 0.0399 
                 0.2100 
                 0.2552 
                 0.6290 
               
               
                 3599 
                 0.1514 
                 0.2443 
                 0.4277 
                 0.5036 
                 0.5029 
                 0.7580 
               
               
                 3602 
                 0.1067 
                 0.2298 
                 0.4316 
                 0.5036 
                 0.3860 
                 0.7252 
               
               
                 3603 
                 0.5341 
                 0.4424 
                 0.8982 
                 0.6233 
                 0.4548 
                 0.7415 
               
               
                 3607 
                 0.0136 
                 0.0833 
                 0.0083 
                 0.0919 
                 0.8241 
                 0.8538 
               
               
                 3608 
                 0.0293 
                 0.1325 
                 0.0657 
                 0.2508 
                 0.6931 
                 0.8380 
               
               
                 3624 
                 0.9279 
                 0.5621 
                 0.9314 
                 0.6284 
                 0.9965 
                 0.8795 
               
               
                 3627 
                 0.1279 
                 0.2311 
                 0.8037 
                 0.6041 
                 0.1964 
                 0.5917 
               
               
                 3628 
                 0.9903 
                 0.5795 
                 0.7214 
                 0.5835 
                 0.7305 
                 0.8380 
               
               
                 3636 
                 0.3080 
                 0.3362 
                 0.8352 
                 0.6041 
                 0.4134 
                 0.7283 
               
               
                 3641 
                 0.0142 
                 0.0854 
                 0.5193 
                 0.5467 
                 0.0033 
                 0.0776 
               
               
                 3643 
                 0.0023 
                 0.0325 
                 0.1619 
                 0.3616 
                 0.0001 
                 0.0031 
               
               
                 3644 
                 0.0087 
                 0.0665 
                 0.6521 
                 0.5695 
                 0.0031 
                 0.0771 
               
               
                 3648 
                 0.3678 
                 0.3597 
                 0.2309 
                 0.3905 
                 0.7567 
                 0.8380 
               
               
                 3649 
                 0.0801 
                 0.2064 
                 0.9139 
                 0.6254 
                 0.0650 
                 0.4168 
               
               
                 3650 
                 0.7836 
                 0.5240 
                 0.4937 
                 0.5353 
                 0.6798 
                 0.8357 
               
               
                 3651 
                 0.0112 
                 0.0738 
                 0.2116 
                 0.3803 
                 0.0006 
                 0.0192 
               
               
                 3653 
                 0.0149 
                 0.0877 
                 0.0261 
                 0.1631 
                 0.7961 
                 0.8458 
               
               
                 3654 
                 0.8166 
                 0.5274 
                 0.0201 
                 0.1413 
                 0.0121 
                 0.1630 
               
               
                 3656 
                 0.5640 
                 0.4500 
                 0.6367 
                 0.5695 
                 0.9158 
                 0.8691 
               
               
                 3658 
                 0.2269 
                 0.2893 
                 0.1717 
                 0.3733 
                 0.8661 
                 0.8610 
               
               
                 3662 
                 0.2810 
                 0.3162 
                 0.2413 
                 0.4006 
                 0.9217 
                 0.8691 
               
               
                 3663 
                 0.1609 
                 0.2443 
                 0.3205 
                 0.4661 
                 0.6665 
                 0.8314 
               
               
                 3664 
                 0.0570 
                 0.1757 
                 0.0158 
                 0.1236 
                 0.5441 
                 0.7770 
               
               
                 3667 
                 0.1378 
                 0.2318 
                 0.2031 
                 0.3759 
                 0.8206 
                 0.8519 
               
               
                 3668 
                 0.4944 
                 0.4305 
                 0.5523 
                 0.5606 
                 0.9280 
                 0.8691 
               
               
                 3670 
                 0.0837 
                 0.2140 
                 0.1951 
                 0.3759 
                 0.6368 
                 0.8251 
               
               
                 3694 
                 0.0023 
                 0.0325 
                 0.5766 
                 0.5622 
                 0.0085 
                 0.1331 
               
               
                 3698 
                 0.3311 
                 0.3473 
                 0.3420 
                 0.4761 
                 0.0629 
                 0.4168 
               
               
                 3714 
                 0.0104 
                 0.0719 
                 0.0090 
                 0.0919 
                 0.9463 
                 0.8691 
               
               
                 3715 
                 0.0704 
                 0.1968 
                 0.3434 
                 0.4761 
                 0.3581 
                 0.7028 
               
               
                 3718 
                 0.1859 
                 0.2619 
                 0.4513 
                 0.5197 
                 0.5542 
                 0.7770 
               
               
                 3727 
                 0.5952 
                 0.4584 
                 0.0421 
                 0.2154 
                 0.1184 
                 0.5242 
               
               
                 3728 
                 0.5890 
                 0.4576 
                 0.8945 
                 0.6233 
                 0.5022 
                 0.7580 
               
               
                 3751 
                 0.2320 
                 0.2930 
                 0.0020 
                 0.0462 
                 0.0312 
                 0.2992 
               
               
                 3754 
                 0.4775 
                 0.4222 
                 0.1407 
                 0.3366 
                 0.0353 
                 0.3175 
               
               
                 3757 
                 0.0036 
                 0.0444 
                 1.0000 
                 0.6499 
                 0.0036 
                 0.0827 
               
               
                 3771 
                 0.8174 
                 0.5274 
                 0.7150 
                 0.5835 
                 0.5524 
                 0.7770 
               
               
                 3978 
                 0.3288 
                 0.3473 
                 0.2446 
                 0.4041 
                 0.8450 
                 0.8610 
               
               
                 4000 
                 0.0480 
                 0.1705 
                 0.0082 
                 0.0919 
                 0.4183 
                 0.7283 
               
               
                 4079 
                 0.1101 
                 0.2298 
                 0.0023 
                 0.0479 
                 0.0850 
                 0.4957 
               
               
                 4108 
                 0.0005 
                 0.0121 
                 0.2899 
                 0.4489 
                 0.0059 
                 0.1143 
               
               
                 4131 
                 0.6703 
                 0.4860 
                 0.6994 
                 0.5811 
                 0.4197 
                 0.7283 
               
               
                 4144 
                 0.0446 
                 0.1640 
                 0.3567 
                 0.4766 
                 0.2443 
                 0.6224 
               
               
                 4221 
                 0.0001 
                 0.0019 
                 0.0450 
                 0.2206 
                 0.0082 
                 0.1319 
               
               
                 4246 
                 0.0000 
                 0.0015 
                 0.0216 
                 0.1420 
                 0.0110 
                 0.1537 
               
               
                 4274 
                 0.0052 
                 0.0517 
                 0.3017 
                 0.4575 
                 0.0004 
                 0.0158 
               
               
                 4363 
                 0.0892 
                 0.2167 
                 0.4952 
                 0.5353 
                 0.2879 
                 0.6507 
               
               
                 4756 
                 0.2067 
                 0.2747 
                 0.7881 
                 0.6001 
                 0.3141 
                 0.6797 
               
               
                 4832 
                 0.0326 
                 0.1393 
                 0.0580 
                 0.2403 
                 0.7786 
                 0.8418 
               
               
                 4835 
                 0.0010 
                 0.0234 
                 0.4269 
                 0.5036 
                 0.0064 
                 0.1195 
               
               
                 4899 
                 0.0440 
                 0.1640 
                 0.1216 
                 0.3029 
                 0.0012 
                 0.0380 
               
               
                 4926 
                 1.0000 
                 0.5814 
                 0.0051 
                 0.0717 
                 0.0051 
                 0.1021 
               
               
                 4930 
                 0.0000 
                 0.0007 
                 0.5097 
                 0.5413 
                 0.0001 
                 0.0026 
               
               
                 4971 
                 0.0559 
                 0.1757 
                 0.0703 
                 0.2551 
                 0.9080 
                 0.8681 
               
               
                   
               
            
           
         
       
     
     Example 9: Table 5 for Examples 1-3, Provided as Parts Tables 5A Though 5F 
     Tables 5A through 5F (collectively “Table 5”) relate to the top 22 maternal serum and fetal brain metabolites downregulated in GF and ABX relative to SPF and Sp. The cells can be classified from the given data based on p&lt;0.05 or 0.05&lt;p&lt;0.10, as well as based on the mean values being significantly higher or not for each comparison. In addition, the biochemicals found unpregulated in SPF and Sp compared to ABX and GF in both serum and brain can be extracted from the provided data (imidazole propionate; N,N,N-trimethyl-5-aminovalerate; 3-indoxyl sulfate; trimethylamine N-oxide; biotin; hippurate; stachydrine; pyrraline). 
     Tables 5A through 5C provide data for maternal serum, whereas Tables 5D through 5F provide data for fetal brain. Tables 5A and 5D provide “fold of change,” and the remaining sub-tables of Table 5 provide the ANOVA contrasts. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE 5A 
               
               
                   
               
               
                 Biochemical Name 
                 Sp/SPF 
                 ABX/SPF 
                 GF/SPF 
                 Sp/ABX 
                 GF/ABX 
                 GF/Sp 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 alpha-ketoglutaramate* 
                 1.37 
                 0.61 
                 0.49 
                 2.23 
                 0.81 
                 0.36 
               
               
                 imidazole propionate 
                 2.40 
                 0.35 
                 0.22 
                 6.90 
                 0.62 
                 0.09 
               
               
                 N,N,N-trimethyl-5-aminovalerate 
                 2.37 
                 0.13 
                 0.19 
                 18.06 
                 1.45 
                 0.08 
               
               
                 indolepropionate 
                 0.70 
                 0.01 
                 0.00 
                 54.72 
                 0.24 
                 0.00 
               
               
                 3-indoxyl sulfate 
                 0.52 
                 0.43 
                 0.00 
                 1.20 
                 0.00 
                 0.00 
               
               
                 trimethylamine N-oxide 
                 0.36 
                 0.16 
                 0.02 
                 2.33 
                 0.10 
                 0.04 
               
               
                 beta-muricholate 
                 6.42 
                 0.01 
                 0.01 
                 676.89 
                 1.27 
                 0.00 
               
               
                 alpha-muricholate 
                 8.04 
                 0.04 
                 0.04 
                 221.52 
                 1.00 
                 0.00 
               
               
                 deoxycholate 
                 1.69 
                 0.01 
                 0.02 
                 115.92 
                 1.05 
                 0.01 
               
               
                 taurodeoxycholate 
                 0.07 
                 0.00 
                 0.00 
                 21.07 
                 1.00 
                 0.05 
               
               
                 ursodeoxycholate 
                 3.73 
                 0.02 
                 0.02 
                 201.13 
                 1.00 
                 0.00 
               
               
                 taurohyodeoxycholic acid 
                 0.16 
                 0.01 
                 0.00 
                 17.84 
                 0.47 
                 0.03 
               
               
                 7-ketodeoxycholate 
                 3.31 
                 0.00 
                 0.00 
                 717.10 
                 1.00 
                 0.00 
               
               
                 biotin 
                 1.50 
                 0.44 
                 0.44 
                 3.41 
                 0.99 
                 0.29 
               
               
                 hippurate 
                 0.47 
                 0.02 
                 0.02 
                 23.99 
                 0.78 
                 0.03 
               
               
                 p-cresol sulfate 
                 0.59 
                 0.02 
                 0.02 
                 30.11 
                 1.04 
                 0.03 
               
               
                 phenylpropionylglycine 
                 0.60 
                 0.01 
                 0.01 
                 72.57 
                 1.00 
                 0.01 
               
               
                 3-(3-hydroxyphenyl)propionate sulfate 
                 0.07 
                 0.01 
                 0.01 
                 7.24 
                 1.00 
                 0.14 
               
               
                 2-(4-hydroxyphenyl)propionate 
                 0.99 
                 0.06 
                 0.06 
                 16.71 
                 1.00 
                 0.06 
               
               
                 3-phenylpropionate (hydrocinnamate) 
                 1.72 
                 0.07 
                 0.12 
                 25.21 
                 1.72 
                 0.07 
               
               
                 stachydrine 
                 0.92 
                 0.63 
                 0.59 
                 1.45 
                 0.94 
                 0.65 
               
               
                 pyrraline 
                 1.03 
                 0.59 
                 0.44 
                 1.73 
                 0.74 
                 0.43 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 5B 
               
             
            
               
                   
                   
               
               
                   
                 Sp/SPF 
                 ABX/SPF 
                 GF/SPF 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Biochemical Name 
                 p-value 
                 q-value 
                 p-value 
                 q-value 
                 p-value 
                 q-value 
               
               
                   
               
               
                 alpha-ketoglutaramate* 
                 0.1410 
                 0.7037 
                 0.0422 
                 0.2485 
                 0.0048 
                 0.0281 
               
               
                 imidazole propionate 
                 0.0014 
                 0.0451 
                 0.0001 
                 0.0021 
                 0.0000 
                 0.0000 
               
               
                 N,N,N-trimethyl-5-aminovalerate 
                 0.0001 
                 0.0038 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 indolepropionate 
                 0.4484 
                 0.9734 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 3-indoxyl sulfate 
                 0.1140 
                 0.6811 
                 0.0350 
                 0.2157 
                 0.0000 
                 0.0000 
               
               
                 trimethylamine N-oxide 
                 0.0259 
                 0.3001 
                 0.0001 
                 0.0010 
                 0.0000 
                 0.0000 
               
               
                 beta-muricholate 
                 0.0245 
                 0.2975 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 alpha-muricholate 
                 0.0457 
                 0.3999 
                 0.0010 
                 0.0117 
                 0.0010 
                 0.0068 
               
               
                 deoxycholate 
                 0.3135 
                 0.9011 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 taurodeoxycholate 
                 0.0263 
                 0.3001 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 ursodeoxycholate 
                 0.0259 
                 0.3001 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 taurohyodeoxycholic acid 
                 0.2745 
                 0.8757 
                 0.0000 
                 0.0007 
                 0.0000 
                 0.0000 
               
               
                 7-ketodeoxycholate 
                 0.1494 
                 0.7164 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 biotin 
                 0.0342 
                 0.3258 
                 0.0001 
                 0.0011 
                 0.0001 
                 0.0007 
               
               
                 hippurate 
                 0.1238 
                 0.7020 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 p-cresol sulfate 
                 0.3343 
                 0.9196 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 phenylpropionylglycine 
                 0.2613 
                 0.8757 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 3-(3-hydroxyphenyl)propionate sulfate 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 2-(4-hydroxyphenyl)propionate 
                 0.3603 
                 0.9196 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 3-phenylpropionate (hydrocinnamate) 
                 0.8014 
                 1.0000 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 stachydrine 
                 0.6362 
                 0.9975 
                 0.0247 
                 0.1690 
                 0.0090 
                 0.0468 
               
               
                 pyrraline 
                 0.8498 
                 1.0000 
                 0.0673 
                 0.3424 
                 0.0002 
                 0.0014 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 5C 
               
             
            
               
                   
                   
               
               
                   
                 Sp/ABX 
                 GF/ABX 
                 GF/Sp 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Biochemical Name 
                 p-value 
                 q-value 
                 p-value 
                 q-value 
                 p-value 
                 q-value 
               
               
                   
               
               
                 alpha-ketoglutaramate* 
                 0.0009 
                 0.0093 
                 0.3789 
                 0.9355 
                 0.0001 
                 0.0005 
               
               
                 imidazole propionate 
                 0.0000 
                 0.0000 
                 0.0451 
                 0.4249 
                 0.0000 
                 0.0000 
               
               
                 N,N,N-trimethyl-5-aminovalerate 
                 0.0000 
                 0.0000 
                 0.0781 
                 0.5552 
                 0.0000 
                 0.0000 
               
               
                 indolepropionate 
                 0.0000 
                 0.0000 
                 0.3756 
                 0.9355 
                 0.0000 
                 0.0000 
               
               
                 3-indoxyl sulfate 
                 0.5737 
                 0.6872 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 trimethylamine N-oxide 
                 0.0369 
                 0.1821 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 beta-muricholate 
                 0.0000 
                 0.0000 
                 0.6005 
                 1.0000 
                 0.0000 
                 0.0000 
               
               
                 alpha-muricholate 
                 0.0000 
                 0.0000 
                 1.0000 
                 1.0000 
                 0.0000 
                 0.0000 
               
               
                 deoxycholate 
                 0.0000 
                 0.0000 
                 0.8840 
                 1.0000 
                 0.0000 
                 0.0000 
               
               
                 taurodeoxycholate 
                 0.0000 
                 0.0003 
                 1.0000 
                 1.0000 
                 0.0000 
                 0.0002 
               
               
                 ursodeoxycholate 
                 0.0000 
                 0.0000 
                 1.0000 
                 1.0000 
                 0.0000 
                 0.0000 
               
               
                 taurohyodeoxycholic acid 
                 0.0011 
                 0.0112 
                 0.3075 
                 0.9193 
                 0.0000 
                 0.0005 
               
               
                 7-ketodeoxycholate 
                 0.0000 
                 0.0000 
                 1.0000 
                 1.0000 
                 0.0000 
                 0.0000 
               
               
                 biotin 
                 0.0000 
                 0.0000 
                 0.9763 
                 1.0000 
                 0.0000 
                 0.0000 
               
               
                 hippurate 
                 0.0000 
                 0.0000 
                 0.4182 
                 0.9628 
                 0.0000 
                 0.0000 
               
               
                 p-cresol sulfate 
                 0.0000 
                 0.0000 
                 0.9657 
                 1.0000 
                 0.0000 
                 0.0000 
               
               
                 phenylpropionylglycine 
                 0.0000 
                 0.0000 
                 1.0000 
                 1.0000 
                 0.0000 
                 0.0000 
               
               
                 3-(3-hydroxyphenyl)propionate sulfate 
                 0.0000 
                 0.0000 
                 1.0000 
                 1.0000 
                 0.0000 
                 0.0000 
               
               
                 2-(4-hydroxyphenyl)propionate 
                 0.0000 
                 0.0000 
                 1.0000 
                 1.0000 
                 0.0000 
                 0.0000 
               
               
                 3-phenylpropionate (hydrocinnamate) 
                 0.0000 
                 0.0000 
                 0.2181 
                 0.8254 
                 0.0000 
                 0.0000 
               
               
                 stachydrine 
                 0.0706 
                 0.2607 
                 0.6835 
                 1.0000 
                 0.0288 
                 0.0948 
               
               
                 pyrraline 
                 0.0448 
                 0.2021 
                 0.0280 
                 0.3460 
                 0.0001 
                 0.0008 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE 5D 
               
               
                   
               
               
                 Biochemical Name 
                 Sp/SPF 
                 ABX/SPF 
                 GF/SPF 
                 Sp/ABX 
                 GF/ABX 
                 GF/Sp 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 glutamine 
                 0.86 
                 0.70 
                 0.67 
                 1.23 
                 0.96 
                 0.78 
               
               
                 alpha-ketoglutaramate* 
                 1.87 
                 0.77 
                 0.63 
                 2.42 
                 0.81 
                 0.34 
               
               
                 pyroglutamine* 
                 0.97 
                 0.73 
                 0.51 
                 1.34 
                 0.70 
                 0.52 
               
               
                 imidazole propionate 
                 1.60 
                 0.33 
                 0.33 
                 4.81 
                 0.99 
                 0.20 
               
               
                 anserine 
                 0.82 
                 0.40 
                 0.42 
                 2.04 
                 1.04 
                 0.51 
               
               
                 N2-acetyllysine 
                 0.88 
                 0.49 
                 0.58 
                 1.80 
                 1.18 
                 0.66 
               
               
                 N6-methyllysine 
                 0.86 
                 0.64 
                 0.57 
                 1.35 
                 0.89 
                 0.66 
               
               
                 N,N,N-trimethyl-5-aminovalerate 
                 1.79 
                 0.09 
                 0.16 
                 19.45 
                 1.71 
                 0.09 
               
               
                 3-indoxyl sulfate 
                 0.56 
                 0.31 
                 0.08 
                 1.79 
                 0.25 
                 0.14 
               
               
                 3-sulfo-L-alanine 
                 0.92 
                 0.37 
                 0.40 
                 2.49 
                 1.08 
                 0.43 
               
               
                 phenylacetylglycine 
                 0.80 
                 0.45 
                 0.45 
                 1.79 
                 1.00 
                 0.56 
               
               
                 arachidoylcarnitine (C20)* 
                 1.03 
                 0.75 
                 0.83 
                 1.36 
                 1.10 
                 0.80 
               
               
                 trimethylamine N-oxide 
                 0.38 
                 0.08 
                 0.04 
                 4.61 
                 0.48 
                 0.10 
               
               
                 sphingomyelin (d18:1/20:0, d16:1/22:0)* 
                 0.84 
                 0.68 
                 0.69 
                 1.24 
                 1.02 
                 0.83 
               
               
                 trigonelline (N′-methylnicotinate) 
                 0.90 
                 0.58 
                 0.55 
                 1.55 
                 0.95 
                 0.61 
               
               
                 pantothenate 
                 0.98 
                 0.80 
                 0.72 
                 1.22 
                 0.90 
                 0.74 
               
               
                 biotin 
                 0.81 
                 0.37 
                 0.44 
                 2.17 
                 1.17 
                 0.54 
               
               
                 hippurate 
                 0.42 
                 0.24 
                 0.24 
                 1.72 
                 1.00 
                 0.58 
               
               
                 homostachydrine* 
                 0.72 
                 0.38 
                 0.46 
                 1.91 
                 1.24 
                 0.65 
               
               
                 stachydrine 
                 0.77 
                 0.44 
                 0.57 
                 1.75 
                 1.28 
                 0.73 
               
               
                 pyrraline 
                 0.98 
                 0.46 
                 0.40 
                 2.14 
                 0.87 
                 0.41 
               
               
                 O-sulfo-L-tyrosine 
                 0.95 
                 0.47 
                 0.58 
                 2.01 
                 1.22 
                 0.61 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 5E 
               
             
            
               
                   
                   
               
               
                   
                 Sp/SPF 
                 ABX/SPF 
                 GF/SPF 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Biochemical Name 
                 p-value 
                 q-value 
                 p-value 
                 q-value 
                 p-value 
                 q-value 
               
               
                   
               
               
                 glutamine 
                 0.0903 
                 0.0627 
                 0.0010 
                 0.0037 
                 0.0003 
                 0.0015 
               
               
                 alpha-ketoglutaramate* 
                 0.0006 
                 0.0059 
                 0.1065 
                 0.0509 
                 0.0061 
                 0.0089 
               
               
                 pyroglutamine* 
                 0.9870 
                 0.3040 
                 0.0347 
                 0.0252 
                 0.0001 
                 0.0006 
               
               
                 imidazole propionate 
                 0.0121 
                 0.0243 
                 0.0000 
                 0.0001 
                 0.0000 
                 0.0001 
               
               
                 anserine 
                 0.5221 
                 0.1970 
                 0.0042 
                 0.0068 
                 0.0025 
                 0.0052 
               
               
                 N2-acetyllysine 
                 0.3313 
                 0.1431 
                 0.0010 
                 0.0038 
                 0.0049 
                 0.0076 
               
               
                 N6-methyllysine 
                 0.1851 
                 0.0975 
                 0.0010 
                 0.0037 
                 0.0001 
                 0.0006 
               
               
                 N,N,N-trimethyl-5-aminovalerate 
                 0.0019 
                 0.0111 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 3-indoxyl sulfate 
                 0.0326 
                 0.0377 
                 0.0000 
                 0.0005 
                 0.0000 
                 0.0000 
               
               
                 3-sulfo-L-alanine 
                 0.5338 
                 0.2006 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0001 
               
               
                 phenylacetylglycine 
                 0.5433 
                 0.2032 
                 0.0079 
                 0.0096 
                 0.0079 
                 0.0107 
               
               
                 arachidoylcarnitine (C20)* 
                 0.7317 
                 0.2468 
                 0.0046 
                 0.0069 
                 0.0445 
                 0.0332 
               
               
                 trimethylamine N-oxide 
                 0.0018 
                 0.0110 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 sphingomyelin (d18:1/20:0, d16:1/22:0)* 
                 0.1795 
                 0.0960 
                 0.0045 
                 0.0069 
                 0.0048 
                 0.0076 
               
               
                 trigonelline (N′-methylnicotinate) 
                 0.4532 
                 0.1780 
                 0.0025 
                 0.0055 
                 0.0005 
                 0.0022 
               
               
                 pantothenate 
                 0.6854 
                 0.2376 
                 0.0044 
                 0.0069 
                 0.0002 
                 0.0014 
               
               
                 biotin 
                 0.4864 
                 0.1893 
                 0.0004 
                 0.0025 
                 0.0017 
                 0.0038 
               
               
                 hippurate 
                 0.0000 
                 0.0008 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0000 
               
               
                 homostachydrine* 
                 0.0336 
                 0.0377 
                 0.0000 
                 0.0001 
                 0.0000 
                 0.0004 
               
               
                 stachydrine 
                 0.0223 
                 0.0321 
                 0.0000 
                 0.0000 
                 0.0000 
                 0.0003 
               
               
                 pyrraline 
                 0.8733 
                 0.2799 
                 0.0036 
                 0.0064 
                 0.0003 
                 0.0016 
               
               
                 O-sulfo-L-tyrosine 
                 0.7093 
                 0.2411 
                 0.0004 
                 0.0025 
                 0.0027 
                 0.0053 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 5F 
               
             
            
               
                   
                   
               
               
                   
                 Sp/ABX 
                 GF/ABX 
                 GF/Sp 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Biochemical Name 
                 p-value 
                 q-value 
                 p-value 
                 q-value 
                 p-value 
                 q-value 
               
               
                   
               
               
                 glutamine 
                 0.0500 
                 0.1713 
                 0.5935 
                 0.5688 
                 0.0161 
                 0.2066 
               
               
                 alpha-ketoglutaramate* 
                 0.0000 
                 0.0007 
                 0.1850 
                 0.3746 
                 0.0000 
                 0.0001 
               
               
                 pyroglutamine* 
                 0.0359 
                 0.1496 
                 0.0114 
                 0.1024 
                 0.0001 
                 0.0026 
               
               
                 imidazole propionate 
                 0.0000 
                 0.0000 
                 0.9507 
                 0.6291 
                 0.0000 
                 0.0000 
               
               
                 anserine 
                 0.0181 
                 0.0987 
                 0.8231 
                 0.6041 
                 0.0111 
                 0.1537 
               
               
                 N2-acetyllysine 
                 0.0100 
                 0.0718 
                 0.5070 
                 0.5413 
                 0.0423 
                 0.3453 
               
               
                 N6-methyllysine 
                 0.0217 
                 0.1120 
                 0.2581 
                 0.4219 
                 0.0016 
                 0.0466 
               
               
                 N,N,N-trimethyl-5-aminovalerate 
                 0.0000 
                 0.0000 
                 0.0059 
                 0.0770 
                 0.0000 
                 0.0000 
               
               
                 3-indoxyl sulfate 
                 0.0078 
                 0.0610 
                 0.0000 
                 0.0068 
                 0.0000 
                 0.0000 
               
               
                 3-sulfo-L-alanine 
                 0.0000 
                 0.0004 
                 0.5749 
                 0.5622 
                 0.0000 
                 0.0009 
               
               
                 phenylacetylglycine 
                 0.0303 
                 0.1333 
                 1.0000 
                 0.6499 
                 0.0303 
                 0.2992 
               
               
                 arachidoylcarnitine (C20)* 
                 0.0021 
                 0.0325 
                 0.3098 
                 0.4633 
                 0.0216 
                 0.2516 
               
               
                 trimethylamine N-oxide 
                 0.0000 
                 0.0008 
                 0.0089 
                 0.0919 
                 0.0000 
                 0.0000 
               
               
                 sphingomyelin (d18:1/20:0, d16:1/22:0)* 
                 0.0863 
                 0.2155 
                 0.9790 
                 0.6396 
                 0.0907 
                 0.5044 
               
               
                 trigonelline (N′-methylnicotinate) 
                 0.0142 
                 0.0854 
                 0.5193 
                 0.5467 
                 0.0033 
                 0.0776 
               
               
                 pantothenate 
                 0.0112 
                 0.0738 
                 0.2116 
                 0.3803 
                 0.0006 
                 0.0192 
               
               
                 biotin 
                 0.0023 
                 0.0325 
                 0.5766 
                 0.5622 
                 0.0085 
                 0.1331 
               
               
                 hippurate 
                 0.0036 
                 0.0444 
                 1.0000 
                 0.6499 
                 0.0036 
                 0.0827 
               
               
                 homostachydrine* 
                 0.0005 
                 0.0121 
                 0.2899 
                 0.4489 
                 0.0059 
                 0.1143 
               
               
                 stachydrine 
                 0.0001 
                 0.0019 
                 0.0450 
                 0.2206 
                 0.0082 
                 0.1319 
               
               
                 pyrraline 
                 0.0052 
                 0.0517 
                 0.3017 
                 0.4575 
                 0.0004 
                 0.0158 
               
               
                 O-sulfo-L-tyrosine 
                 0.0010 
                 0.0234 
                 0.4269 
                 0.5036 
                 0.0064 
                 0.1195 
               
               
                   
               
            
           
         
       
     
     INCORPORATION BY REFERENCE 
     All publications and patents mentioned herein are hereby incorporated by reference in their entirety as if each individual publication or patent was specifically and individually indicated to be incorporated by reference. In case of conflict, the present application, including any definitions herein, will control. 
     EQUIVALENTS 
     While specific embodiments of the subject invention have been discussed, the above specification is illustrative and not restrictive. Many variations of the invention will become apparent to those skilled in the art upon review of this specification and the claims below. The full scope of the invention should be determined by reference to the claims, along with their full scope of equivalents, and the specification, along with such variations.