Patent Publication Number: US-8115027-B2

Title: NPY Y5 antagonist

Description:
This application is a Divisional of application Ser. No. 11/520,772 filed Sep. 14, 2006, now U.S. Pat. No. 7,781,461 which is a Divisional of Ser. No. 10/747,034 filed Dec. 30, 2003, now abandoned which is a Divisional of Ser. No. 10/111,981 filed on May 1, 2002, now U.S. Pat. No. 6,699,891 issued Mar. 2, 2004 and for which priority is claimed under 35 U.S.C. §120. Application Ser. No. 10/111,981 is the national phase of PCT International Application No. PCT/JP00/08197 filed on Nov. 21, 2000 under 35 USC §371. This application also claims priority of application Ser. Nos. 11-336469 and 11-353786 filed in Japan on Nov. 26, 1999 and Dec. 14, 1999, respectively, under 35 U.S.C. §119. 
    
    
     TECHNICAL FIELD 
     The present invention relates to a pharmaceutical composition for use as an NPY Y5 receptor antagonist, specifically, anti-obestic agent and novel compounds having an anti-obestic activity. 
     BACKGROUND ART 
     Neuropeptide Y (hereinafter referred to as NPY) is a peptide which consists of 36 amino acid residues and was isolated from porcine brain in 1982. NPY is widely distributed in the central nervous system and peripheral tissues of humans and animals. 
     It has been reported that NPY possesses a stimulating activity of food intake, an anti-seizure activity, a learning promoting activity, an anti-anxiety activity, an anti-stress activity, etc. in central nervous system, and it may be pivotally involved in the central nervous system diseases such as depression, Alzheimer&#39;s disease and Parkinson&#39;s disease. NPY is thought to be associated with the cardiovascular diseases, since it induces a contraction of smooth muscles such as blood vessels or cardiac muscles in the peripheral tissues. Furthermore, NPY is also known to be involved in the metabolic diseases such as obesity, diabetes, and hormone abnormalities (Trends in Pharmacological Sciences, Vol. 15, and 153 (1994)). Therefore, an NPY receptor antagonist is expected as a medicine for preventing or treating various diseases involved in the NPY receptor. 
     Subtypes of Y1, Y2, Y3, Y4, Y5, and Y6 have now been identified as the NPY receptor (Trends in Pharmacological Sciences, Vol. 18, and 372 (1997)). It has been suggested that the Y5 receptor is at least involved in the feeding behavior and its antagonist is expected as an anti-obestic agent (Peptides, Vol. 18, and 445 (1997)). 
     Quinazoline compounds having similar structures to those of the compounds of the present invention and exhibiting an NPY receptor antagonistic activity are described in WO97/20820, WO97/20821, WO97/20823 and the like. In addition, it is described that urea derivatives having a sulfonamide group and amide derivatives having a sulfonyl group in WO 99/64394 and benzyl sulfonamide derivatives in EP1010691-A, have an NPY antagonistic activity. 
     Compounds having similar structures to those of the compounds of the present invention are described in JP59-16871-A and WO97/15567. Their activities are quite different from that of the present invention and these documents do not suggest the present invention. 
     DISCLOSURE OF INVENTION 
     The object of the present invention is to provide a superior pharmaceutical composition for use as an NPY Y5 receptor antagonist and novel compounds having the activity. 
     The present invention provides
     [1] A pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I):   

     
       
         
         
             
             
         
       
         
         wherein R 1  is optionally substituted lower alkyl, optionally substituted cycloalkyl or optionally substituted aryl, 
         R 2  is hydrogen or lower alkyl, and R 1  and R 2  taken together may form lower alkylene, 
         n is 1 or 2, 
         X is optionally substituted lower alkylene, 
         optionally substituted lower alkenylene, 
         optionally substituted —CO-lower alkylene, 
         optionally substituted —CO-lower alkenylene or 
       
    
     
       
         
         
             
             
         
       
         
         
           
             wherein R 3 , R 4 , R 5  and R 6  are each independently hydrogen or lower alkyl, 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
              is optionally substituted cycloalkylene, optionally substituted cycloalkenylene, optionally substituted bicycloalkylene, optionally substituted arylene or optionally substituted heterocyclediyl and p and q are each independently 0 or 1, 
           
         
         —NR 2 —X— may be 
       
    
     
       
         
         
             
             
         
       
         
         
           
             wherein 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
              is piperidinediyl, piperazinediyl, pyridinediyl, pyrazinediyl, pyrrolidinediyl or pyrrolediyl and U is single bond, lower alkylene or lower alkenylene, 
           
         
         Y is OCONR 7 , CONR 7 , CSNR 7 , NR 7 CO or NR 7 CS, 
         R 7  is hydrogen or lower alkyl, and 
         Z is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted amino, optionally substituted lower alkoxy, optionally substituted carbocyclyl or optionally substituted heterocyclyl, prodrug, pharmaceutically acceptable salt or solvate thereof, 
         [2] The pharmaceutical composition for use as an NPY Y5 receptor antagonist described in [1] wherein R 2  is hydrogen or lower alkyl and Z is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted carbocyclyl, optionally substituted heterocyclyl or optionally substituted amino, provided that R 1  is optionally substituted C3 to C10 alkyl when Z is optionally substituted amino, 
         [3] The pharmaceutical composition for use as an NPY Y5 receptor antagonist described in [1] wherein R 1  is optionally substituted lower alkyl or optionally 
       
    
     
       
         
         
             
             
         
       
         
          substituted 
       
    
     
       
         
         
             
             
         
       
         
          cycloalkyl, X is optionally substituted lower alkylene, optionally substituted lower alkenylene or 
         wherein is the same as defined in [1], and 
         Z is optionally substituted lower alkyl, optionally substituted carbocyclyl or optionally substituted heterocyclyl, 
         [4] The pharmaceutical composition for use as an NPY Y5 receptor antagonist described in any one of [1] to [3] wherein R 1  is optionally substituted C3 to C10 alkyl, 
         [5] The pharmaceutical composition for use as an NPY Y5 receptor antagonist described in any one of [1] to [4] which is an anti-obestic agent, 
         [6] The pharmaceutical composition for use as an NPY Y5 receptor antagonist described in any one of [1] to [4] which is an anorectic agent, 
         [7] A method for treating and/or preventing obesity comprising administering an effective dose of an NPY Y5 receptor antagonist described in any one of [1] to [4], 
         [8] A method for suppressing food intake comprising administering an effective dose of an NPY Y5 receptor antagonist described in any one of [1] to [4], 
         [9] Use of an NPY Y5 receptor antagonist described in any one of [1] to [4] for manufacturing a medicine for treating and/or preventing obesity, 
         [10] Use of an NPY Y5 receptor antagonist described in any one of [1] to [4] for manufacturing a medicine for suppressing food intake, 
         [11] A compound of the formula (I): 
       
    
     
       
         
         
             
             
         
       
         
         wherein X is C2 to C6 alkylene or C3 to C6 alkenylene, R 1  is optionally substituted C3 to C10 alkyl or optionally substituted C5 to C6 cycloalkyl and the other symbols are the same as defined in [1], provided that Z is not lower alkylphenylamino, hydroxy(lower)alkylphenylamino and acylphenylamino when Y is NR 7 CO, prodrug, pharmaceutically acceptable salt or solvate thereof, 
         [12] The compound described in [11] wherein Z is optionally substituted lower alkyl or optionally substituted phenyl, prodrug, pharmaceutically acceptable salt or solvate thereof, 
         [13] A compound of the formula (I): 
       
    
     
       
         
         
             
             
         
       
         
         wherein X is 
       
    
     
       
         
         
             
             
         
       
         
          is optionally substituted cycloalkylene, optionally substituted cycloalkenylene, optionally substituted bicycloalkylene or optionally substituted piperidinylene, R 1  is optionally substituted C3 to C10 alkyl or optionally substituted C5 to C6 cycloalkyl and the other symbols are the same as defined in [1], prodrug, pharmaceutically acceptable salt or solvate thereof, 
         [14] The compound described in [13] wherein is optionally substituted cyclohexylene or optionally substituted piperidinylene and p and q are simultaneously 0, prodrug, pharmaceutically acceptable salt or solvate thereof, 
         [15] The compound described in [13] or [14] wherein Y is CONH, prodrug, pharmaceutically acceptable salt or solvate thereof, 
         [16] The compound described in any one of [13] to [15] wherein Z is optionally substituted lower alkyl, optionally substituted phenyl, optionally substituted pyridyl or optionally substituted benzopyranyl, prodrug, pharmaceutically acceptable salt or solvate thereof, 
         [17] A compound of the formula (I): 
       
    
     
       
         
         
             
             
         
       
         
         wherein X is 
       
    
     
       
         
         
             
             
         
       
         
         R 1  is optionally substituted C3 to C10 alkyl or optionally substituted C5 to C6 cycloalkyl, Z is p-(lower)alkylphenyl and the other symbols are the same as defined in [1], provided that Z is not p-n-butylphenyl when R 1  is isopropyl, prodrug, pharmaceutically acceptable salt or solvate thereof, 
         [18] A compound of the formula (I): 
       
    
     
       
         
         
             
             
         
       
         
         wherein X is 
       
    
     
       
         
         
             
             
         
       
         
          is heteroarylene, R 1  is optionally substituted C3 to C10 alkyl or optionally substituted C5 to C6 cycloalkyl and the other symbols are the same as defined in [1], prodrug, pharmaceutically acceptable salt or solvate thereof, 
         [19] The compound described in [18] wherein 
       
    
     
       
         
         
             
             
         
       
         
          is thiophenediyl or furandiyl, prodrug, pharmaceutically acceptable salt or solvate thereof and 
         [20] A pharmaceutical composition comprising the compound described in any one of [11] to [19], prodrug, pharmaceutically acceptable salt or solvate thereof. 
       
    
    
    
     BEST MODE FOR CARRYING OUT THE INVENTION 
     In the present specification, the term “halogen” includes fluorine, chlorine, bromine and iodine. Fluorine or chlorine is preferable. 
     The term “protective group” in “optionally protected hydroxy” and “optionally protected hydroxy(lower)alkyl” includes all of hydroxy protecting groups usually used. For example, acyl such as acetyl, trichloroacetyl and benzoyl, lower alkoxycarbonyl such as t-butoxycarbonyl, lower alkylsulfonyl such as methane sulfonyl, lower alkoxy(lower)alkyl such as methoxymethyl, trialkylsilyl such as t-butyldimethylsilyl are included. 
     The term “lower alkyl” includes C1 to C10 straight or branched alkyl. The examples of “lower alkyl” are methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, hexyl, isohexyl, n-heptyl, isoheptyl, n-octyl, isooctyl, n-nonyl and n-decyl. 
     “Lower alkyl” represented by R 1  is preferably C3 to C10 alkyl, more preferably C3 to C6 alkyl and most preferably isopropyl or t-butyl. 
     “Lower alkyl” in other cases is preferably C1 to C6 alkyl and more preferably C1 to C4 alkyl. 
     The examples of substituents of “optionally substituted lower alkyl” represented by Z are, (1) halogen; (2) cyano;
     (3) the following groups (i) to (xvi), which are optionally substituted with one or more substituents selected from “a substituents group β” defined below,
       (i) hydroxy, (ii) lower alkoxy, (iii) mercapto, (iv) lower alkylthio, (v) acyl, (vi) acyloxy, (vii) carboxy, (viii) lower alkoxycarbonyl, (ix) imino, (x) carbamoyl, (xi) thiocarbamoyl, (xii) lower alkylcarbamoyl, (xiii) lower alkylthiocarbamoyl, (xiv) amino, (xv) lower alkylamino or (xvi) heterocyclylcarbonyl;
 
or
   
       (4) a group of the formula:   

     
       
         
         
             
             
         
       
         
         wherein R 10  and R 11  are each independently hydrogen or lower alkyl and when this group has two or more of R 10  and/or two or more of R 11 , each R 10  and/or each R 11  may be different, 
         W is single bond, O, S or NR 12 , 
         R 12  is hydrogen, lower alkyl or phenyl, 
       
    
     
       
         
         
             
             
         
       
         
          is cycloalkyl, bicycloalkyl, cycloalkenyl, aryl or heterocyclyl, each of which is optionally substituted with one or more of substituents selected from “a substituents group α” defined below and 
         s is an integer of 0 to 4. 
       
    
     In the present specification, “a substituents group α” is a group constituting of (1) halogen; (2) oxo; (3) cyano; (4) nitro; (5) imino optionally substituted with lower alkyl or hydroxy;
     (6) the following groups (i) to (xxi), which are optionally substituted with one or more of groups selected from the substituents group β,
       (i) hydroxy, (ii) lower alkyl, (iii) lower alkenyl, (iv) lower alkoxy, (v) carboxy, (vi) lower alkoxycarbonyl, (vii) acyl, (viii) acyloxy, (ix) imino, (x) mercapto, (xi) lower alkylthio, (xii) carbamoyl, (xiii) lower alkylcarbamoyl, (xiv) cycloalkylcarbamoyl, (xv) thiocarbamoyl, (xvi) lower alkylthiocarbamoyl, (xvii) lower alkylsulfinyl, (xviii) lower alkylsulfonyl, (xix) sulfamoyl, (xx) lower alkylsulfamoyl and (xxi) cycloalkylsulfamoyl;   
       (7) the following groups (i) to (v), which are optionally substituted with the substituents group β, lower alkyl, lower alkoxy(lower)alkyl, optionally protected hydroxy(lower)alkyl, halogeno(lower)alkyl, lower alkylsulfonyl and/or arylsulfonyl,
       (i) cycloalkyl, (ii) cycloalkenyl, (iii) cycloalkyloxy, (iv) amino and (v) alkylenedioxy;
 
and
   
       (8) the following groups (i) to (xii), which are optionally substituted with the substituents group β, lower alkyl, halogeno(lower)alkyl and/or oxo,
       (i) phenyl, (ii) naphthyl, (iii) phenoxy, (iv) phenyl(lower)alkoxy, (v) phenylthio, (vi) phenyl(lower)alkylthio, (vii) phenylazo, (viii) heterocyclyl, (ix) heterocyclyloxy, (x) heterocyclylthio, (xi) heterocyclylcarbonyl and (xii) heterocyclylsulfonyl.   
       

     The preferable examples of the substituents group α as substituents for B ring are halogen; nitro; hydroxy;
     optionally substituted lower alkyl wherein the substituents is halogen, cyano, phenyl, carboxy and/or lower alkoxycarbonyl;   lower alkenyl; lower alkoxycarbonyl(lower)alkenyl;   optionally substituted lower alkoxy wherein the substituents is halogen, hydroxy, lower alkoxy, carboxy, lower alkoxycarbonyl, lower alkylamino and/or cyano;   acyl; hydroxyimino; lower alkylthio; lower alkylsulfinyl; sulfamoyl;   optionally substituted amino wherein the substituents is lower alkyl, optionally protected hydroxy(lower)alkyl, phenyl and/or acyl;   alkylenedioxy; cyanophenyl; heterocyclylphenyl; biphenylyl; phenoxy; phenylazo optionally substituted with lower alkyl; or   optionally substituted heterocyclyl wherein the substituents is optionally protected hydroxy, mercapto, halogen, lower alkyl, cycloalkyl, lower alkoxycarbonyl, amino, lower alkoxycarbonyl amino, carbamoyl, oxo, phenyl, lower alkoxyphenyl or heterocyclyl. More preferable examples are halogen; lower alkyl optionally substituted with halogen; or lower alkoxy optionally substituted with halogen.   

     “A substituents group β” is a group consisting of halogen, optionally protected hydroxy, mercapto, lower alkoxy, lower alkenyl, amino, lower alkylamino, lower alkoxycarbonylamino, lower alkylthio, acyl, carboxy, lower alkoxycarbonyl, carbamoyl, cyano, cycloalkyl, phenyl, phenoxy, lower alkylphenyl, lower alkoxyphenyl, halogenophenyl, naphthyl and heterocyclyl. 
     Examples of the substituents for “optionally substituted lower alkyl” represented by any other than Z (e.g., R 1 ) are one or more substituents selected from the substituents group β. The lower alkyl may be substituted with these substituents at any possible positions. 
     The lower alkyl part in “lower alkoxy”, “lower alkoxycarbonyl”, “lower alkoxycarbonyl(lower)alkyl”, “lower alkylphenyl”, “lower alkoxyphenyl”, “lower alkylcarbamoyl”, “lower alkylthiocarbamoyl”, “lower alkylamino”, “halogeno(lower)alkyl”, “hydroxy(lower)alkyl”, “phenyl(lower)alkoxy”, “lower alkylthio”, “phenyl(lower)alkylthio”, “lower alkoxycarbonylamino”, “lower alkoxycarbonyl(lower)alkenyl”, “lower alkylsulfinyl”, “lower alkylsulfonyl”, “aryl(lower)alkoxycarbonyl”, “lower alkylbenzoyl” and “lower alkoxybenzoyl” is the same as defined in the above “lower alkyl”. 
     Examples of substituents for “optionally substituted lower alkoxy” are one or more substituents selected from the substituents group β. Preferable examples are phenyl, lower alkylphenyl, lower alkoxyphenyl, naphthyl and heterocyclyl. 
     The term “cycloalkyl” includes C3 to C8 cyclic alkyl and preferably C5 to C6 cyclic alkyl. Examples are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl. 
     Examples of substituents for “optionally substituted cycloalkyl” are one or more substituents selected from the substituents group α and the cycloalkyl may be substituted with these substituents at any possible positions. 
     The term “bicycloalkyl” includes a group which is formed by excluding one hydrogen from a C5 to C8 aliphatic cycle containing two rings which possess two or more of atoms in common. Examples are bicyclo[2.1.0]pentyl, bicyclo[2.2.1]heptyl, bicyclo[2.2.2]octyl and bicyclo[3.2.1]octyl. 
     The term “lower alkenyl” includes C2 to C10, preferably C2 to C8 and more preferably C3 to C6 straight or branched alkenyl having one or more double bonds at any possible positions. Examples are vinyl, propenyl, isopropenyl, butenyl, isobutenyl, prenyl, butadienyl, pentenyl, isopentenyl, pentadienyl, hexenyl, isohexenyl, hexadienyl, heptenyl, octenyl, nonenyl and decenyl. 
     The “lower alkenyl” part in “lower alkoxycarbonyl(lower)alkenyl” is the same as the above “lower alkenyl”. 
     Examples of the substituents for “optionally substituted lower alkenyl” are halogen, lower alkoxy, lower alkenyl, amino, lower alkylamino, lower alkoxycarbonylamino, lower alkylthio, acyl, carboxy, lower alkoxycarbonyl, carbamoyl, cyano, cycloalkyl, phenyl, lower alkylphenyl, lower alkoxyphenyl, naphthyl and/or heterocyclyl. 
     The term “acyl” includes (1) C1 to C10, preferably C1 to C6 and more preferably C1 to C4 straight or branched alkylcarbonyl or alkenylcarbonyl, (2) C4 to C9 and preferably C4 to C7 cycloalkylcarbonyl and (3) C7 to C11 arylcarbonyl. Examples are formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, pivaloyl, hexanoyl, acryloyl, propioloyl, methacryloyl, crotonoyl, cyclopropylcarbonyl, cyclohexylcarbonyl, cyclooctylcarbonyl and benzoyl. 
     The “acyl” part in “acyloxy” is the same as the above. 
     The term “cycloalkenyl” includes a group having at least one double bond at any possible positions in the above cycloalkyl. Examples are cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl and cyclohexadienyl. 
     Examples of substituents for “optionally substituted cycloalkenyl” are one or more substituents selected from the substituents group β. 
     Examples of substituents for “optionally substituted amino” are the substituents group β, optionally substituted benzoyl and/or optionally substituted heterocyclylcarbonyl wherein the substituents is hydroxy, lower alkyl, lower alkoxy and/or lower alkylthio. 
     The term “aryl” includes a monocyclic of polycyclic aromatic carbocyclyl group and examples are phenyl, naphthyl, anthryl and phenanthryl, “Aryl” includes aryl fused with other a non-aromatic carbocyclyl group, for example, indanyl, indenyl, biphenylyl, acenaphthyl, tetrahydronaphthyl and fluorenyl. Phenyl is preferable. 
     The aryl part in “aryl lower alkoxycarbonyl” is the same as the above. 
     The term “optionally substituted aryl” and “optionally substituted phenyl” represented by Z include the above “aryl” and “phenyl” respectively, which may be substituted with the substituents group α or lower alkyl which may be substituted with one or more group selected from the substituents group α. 
     Examples of the substituents for “optionally substituted aryl” and “optionally substituted phenyl” represented by any other than Z are one or more groups selected from the substituents group β. 
     The term “carbocyclyl” includes the above “cycloalkyl”, “cycloalkenyl”, “bicycloalkyl” and “aryl”. 
     The term “non-aromatic carbocyclyl” includes the above “cycloalkyl”, “cycloalkenyl” and “bicycloalkyl”. 
     The term “optionally substituted carbocyclyl” includes the above “optionally substituted cycloalkyl”, “optionally substituted cycloalkenyl”, “optionally substituted bicycloalkyl” and “optionally substituted aryl”. 
     The term “heterocyclyl” includes a heterocyclic group containing at least one heteroatom arbitrarily selected from O, S and N. For example, 5-or 6-membered heteroaryl such as pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyridazinyl, pyrimidinyl, oxazolyl, oxadiazolyl, isothiazolyl, thiazolyl, thiadiazolyl, furyl and thienyl; fused heterocyclyl consisting of two rings such as indolyl, isoindolyl, indazolyl, indolizinyl, indolinyl, isoindolinyl, quinolyl, isoquinolyl, cinnolinyl, phthalazinyl, quinazolinyl, naphthyridinyl, quinoxalinyl, purinyl, pteridinyl, benzopyranyl, benzimidazolyl, benzisoxazolyl, benzoxazolyl benzoxadiazolyl, benzisothiazolyl, benzothiazolyl, benzothiadiazolyl, benzofuryl, isobenzofuryl, benzothienyl, benzotriazolyl, imidazopyridyl, triazoropyridyl, imidazothiazolyl, pyrazinopyridazinyl, quinazolinyl, quinolyl, isoquinolyl, naphthyridinyl, dihydropyridyl, tetrahydroquinolyl and tetrahydrobenzothienyl; fused heterocyclyl consisting of three rings such as carbazolyl, acridinyl, xanthenyl, phenothiazinyl, phenoxathiinyl, phenoxazinyl and dibenzofuryl; and non-aromatic heterocyclyl such as dioxanyl, thiiranyl, oxiranyl, oxathiolanyl, azetidinyl, thianyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyrazolinyl, piperidyl, piperazinyl, morpholinyl, morpholino, thiomorpholinyl, thiomorpholino, dihydropyridyl, tetrahydrofuryl, tetrahydropyranyl, tetrahydrothiazolyl and tetrahydroisothiazolyl. 
     “Fused heterocyclyl” fused with a ring other than a heterocycle (e.g., benzothiazolyl), may connect at any possible position. 
     Substituents for “optionally substituted heterocyclyl” are the same as those for the above “optionally substituted aryl”. 
     Heterocyclyl parts in “heterocyclylcarbonyl”, “heterocyclyloxy”, “heterocyclylthio” and “heterocyclyl substituted phenyl” are the same as the above “heterocyclyl”. 
     The term “lower alkylene” includes a bivalent group comprising 1 to 6 of methylene, preferably 2 to 6 of methylene and more preferably 3 to 6 of methylene. For example, methylene, ethylene, trimethylene, tetramethylene, pentamethylene and hexamethylene are included. Tetramethylene is preferable. 
     “R 1  and R 2  taken together may form lower alkylene” includes the case 
                         
Preferable examples are
 
     
       
         
         
             
             
         
       
     
     Lower alkylene part in “lower alkylenedioxy” is the same as the above “lower alkylene”. Methylenedioxy or ethylenedioxy is preferable. 
     The term “lower alkenylene” includes a bivalent group comprising 2 to 6 of methylene, preferably 3 to 6 of methylene and more preferably 4 to 5 of methylene and including at least one double bond. 
     The term “cycloalkylene” includes a bivalent group which is formed by excluding one hydrogen from the above “cycloalkyl”. A preferable example of cycloalkylene represented by X is 1,4-cyclohexanediyl. 
     The term “cycloalkenylene” includes a group containing at least one double bonds in the above cycloalkylene. 
     The term “bicycloalkylene” includes a group which is formed by excluding one hydrogen from the above “bicycloalkyl”. Examples are bicyclo[2.1.0]pentylene, bicyclo[2.2.1]heptylene, bicyclo[2.2.2]octylene, and bicyclo[3.2.1]octylene. 
     The term “heterocyclediyl” includes a bivalent group which is formed by excluding one hydrogen from the above “heterocyclyl”. Piperidinediyl, pyridinediyl, pyrimidinediyl, pyrazinediyl, pyrrolidinediyl or pyrrolediyl is preferable and piperidinediyl is more preferable. 
     The term “arylene” includes a bivalent group which is formed by excluding one hydrogen from the above “aryl”. Phenylene is preferable. 
     The term “heteroarylene” includes aromatic groups in the above “heterocyclediyl”. Examples are pyrrolediyl, imidazolediyl, pyrazolecliyl, pyridinediyl, pyridazinediyl, pyrimidinediyl, pyrazinediyl, triazolediyl, triazinediyl, isoxazolediyl, oxazolediyl, oxadiazolediyl, isothiazolediyl, thiazolediyl, thiadiazolediyl, furandiyl and thiophenediyl. 
     One or more groups selected from the substituents group β are examples of substituents for “optionally substituted lower alkylene”, “optionally substituted lower alkenylene”, “optionally substituted cycloalkylene”, “optionally substituted cyclohexylene”, “optionally substituted bicycloalkylene”, “optionally substituted cycloalkenylene”, “optionally substituted phenylene”, “optionally substituted heterocyclediyl” and “optionally substituted piperidinylene”. Halogen, hydroxy, lower alkyl, halogeno(lower)alkyl, lower alkoxy, amino, lower alkylamino, acyl, carboxy or lower alkoxycarbonyl is preferable. These substituents may attach to any possible positions. 
     When —NR 2 —X— 
                         
is U is preferably single bond or methylene.
 
More preferably,
 
                         
is
 
     
       
         
         
             
             
         
       
     
     The compounds of the present invention include any formable and pharmaceutically acceptable salts thereof. Examples of “the pharmaceutically acceptable salt” are salts with mineral acids such as hydrochloric acid, sulfuric acid, nitric acid and phosphoric acid; salts with organic acids such as para-toluenesulfonic acid, methanesulfonic acid, oxalic acid and citric acid; salts with organic bases such as ammonium, trimethylammonium and triethylammonium; salts with alkaline metals such as sodium and potassium; and salts with alkaline earth metals such as calcium and magnesium. 
     The compounds of the present invention include solvates thereof. Hydrate is preferable and arbitrary numbers of water molecules may coordinate to the compound of the present invention. 
     The compounds of the present invention include prodrugs thereof. Prodrug includes derivatives of the compounds of the present invention which have a chemically or metabolically decomposable group and can be converted into pharmaceutically active compounds of the present invention in vivo by solvolysis or under the physiological conditions. The methods for selecting and producing suitable prodrugs are described in Design of Prodrugs, Elsevier, Amsterdam 1985. 
     When a compound (I) of the present invention has carboxy, examples of prodrugs are an ester derivative and an amide derivative, which can be produced by reacting a compound (I) having carboxy with a suitable alcohol or a suitable amine, respectively. 
     When a compound (I) of the present invention has hydroxy, an example of prodrugs is an acyloxy derivative, which can be synthesized by reacting a compound (I) having hydroxy with a suitable acyl halide or a suitable acid anhydride. 
     When a compound (I) of the present invention has amino, an example of prodrugs is an amide derivative, which can be synthesized by reacting a compound (I) having amino with a suitable acid halide or a suitable mixed acid anhydride. 
     When the compound (I) of the present invention has an asymmetric carbon atom, it includes racemates, all of enantiomers and all of stereoisomers such as diastereomer, epimer and enantiomer thereof. 
     When the compound (I) of the present invention having one or more double bonds forms an E isomer or Z isomer, the compound (I) includes both isomers. When X is cycloalkylene, the compound (I) includes both of cis isomer and trans isomer. 
     For example, the compound (I) of the present invention can be synthesized by the following methods. 
     (Compounds wherein Y═CONR 7 ) 
                         
wherein Hal is halogen, Q is an amino protecting group and the other symbols are the same as the above.
 
Step A
 
     Compound 1 is reacted with Amino Compound 2 having the desired substituent Z and R 7  in a suitable solvent at 0° C. to 50° C. for several minutes to several hours. As solvents, tetrahydrofuran, dimethylformamide, diethyl ether, dichloromethane, toluene, benzene, xylene, cyclohexane, hexane, chloroform, ethyl acetate, butyl acetate, pentane, heptane, dioxane, acetone, acetonitrile, water, a mixture thereof etc. can be used. An activator such as thionyl chloride, acid halide, acid anhydride and activated ester can be used, if necessary. 
     Step B 
     Compound 3 is deprotected by the usual method and reacted with Sulfonyl Halide 4 having the desired substituent R 1  in a suitable solvent at 0° C. to 50° C. for several minutes to several hours to give Compound (I-A) wherein n is 2. Tetrahydrofuran, dimethylformamide, diethyl ether, dichloromethane, toluene, benzene, xylene, cyclohexane, hexane, chloroform, ethyl acetate, butyl acetate, pentane, heptane, dioxane, acetone, acetonitrile, water and the mixture thereof etc. can be used as a solvent. 
     Step C 
     Compound (I-B) wherein n is 1 can be synthesized by reacting Compound 3 with Sulfinyl Halide 5 having substituent R 1 . The conditions for the reaction are the same as those of the above Step B. 
     Step D 
     Compound (I-B) obtained in Step C is oxidized by the usual method to give Compound (I-A) wherein n is 2. m-Chloroperbenzoic acid, peracetic acid, hydrogen peroxide, trifluoroperacetic acid, sodium periodate, sodium hypochlorite, potassium permanganate etc. can be used as an oxidizer and the reaction may be carried out at 0° C. to 50° C. Examples of solvents are tetrahydrofuran, dimethylformamide, diethyl ether, dichloromethane, toluene, benzene, xylene, cyclohexane, hexane, chloroform, ethyl acetate, butyl acetate, pentane, heptane, dioxane, acetone, acetonitrile, water, methanol, ethanol, isopropanol and mixture thereof. 
     In case X is heterocyclediyl containing at least one N atom and the N atom connects to CONR 7 —Z in the compound (I), the following reaction may be employed to obtain Compound (I-A′) or (I-B′). Step D may be carried out just after Step C or Step E. 
                         
wherein R is lower alkyl or aryl and L is a leaving group.
 
Step C
 
     Compound 5 is reacted with Compound 6 in a similar manner to the above Step C to give Compound 7. 
     Step E 
     Thus obtained Compound 7 is treated with a base in a suitable solvent to give Compound 8. For example, barium hydroxide, sodium hydroxide, potassium hydroxide, hydrazine or lithium propanethiolate can be used as a base. As a solvent, tetrahydrofuran, dimethylformamide, dioxane, acetone, acetonitrile, methanol, ethanol, propanol, water, the mixture thereof or the like can be used. The reaction can be carried out at 0° C. to 100° C. for several minutes to several tens hours. 
     Step F 
     Compound 8 is reacted with Compound 9 having a leaving group and a desired substituent in a suitable solvent in the presence or absence of a base at 0° C. to 100° C. for several minutes to several days to give Compound (I-B′). Examples of the leaving group are phenoxy, chloro and trichloromethyl. Examples of the base are triethylamine, pyridine, diisopropylethylamine, sodium hydroxide, potassium carbonate and sodium hydrogencarbonate. Examples of the solvent are tetrahydrofuran, dimethylformamide, diethyl ether, dichloromethane, toluene, benzene, xylene, cyclohexane, hexane, chloroform, ethyl acetate, butyl acetate, pentane, heptane, dioxane, acetone, acetonitrile, methanol, ethanol and the mixture thereof. 
     Step D 
     Compound (I-B′) is reacted in a similar manner to the above Step D to give Compound (I-A′). 
     (Compound wherein Y═NR 7 CO) 
                         
wherein each of the symbols is the same as the above.
 
Step G and Step B
 
     Compound 10 is reacted with Compound 11 under the same reaction condition as that in Step B. Thus obtained Compound 12 is reacted in a similar manner to the above Step B to give Compound (I-C) wherein n=2. 
     Step C and Step D 
     To synthesize Compound (I-D), Compound 12 obtained in Step G may be reacted in similar manners to the above Step C and Step D. 
     (Compound wherein Y═OCONR 7 ) 
                         
wherein each of symbols is the same as the above.
 
Step H
 
     Compound 13 is reacted with Isocianate Compound 14 having a substituent Z in a suitable solvent in the presence or absence of a suitable catalyst at 0° C. to 100° C. for several minutes to several clays to give Compound 15. Examples of the solvent are tetrahydrofuran, dimethylformamide, diethyl ether, dichloromethane, toluene, benzene, xylene, cyclohexane, hexane, chloroform, ethyl acetate, butyl acetate, pentane, heptane, dioxane, acetone, acetonitrile and the mixture thereof. 
     Step C and Step D 
     Thus obtained Compound 15 is reacted in similar manners to Step C and Step D to give Compound (I-E) of the present invention. 
     (Compound wherein Y═CSNR 7  or NR 7 CS) 
     Compound (I) wherein Y is CSNR 7  or NR 7 CS can be synthesized by reacting Compound (I) wherein Y is CONR 7  or NR 7 CO synthesized in any one of the above methods with the Lawesson&#39;s reagent or phosphorus pentasulfide in a suitable solvent at 30° C. to 100° C. for several minutes to several hours. Examples of the solvent are tetrahydrofuran, dimethylformamide, diethyl ether, dichloromethane, toluene, benzene, xylene, cyclohexane, hexane, chloroform, ethyl acetate, butyl acetate, pentane, heptane, dioxane, acetone, acetonitrile and the mixture thereof. 
     Amino groups may be protected with a suitable protecting group in the usual manner at a suitable step. For example, phthalimide, lower alkoxycarbonyl, lower alkenyloxycarbonyl, halogenoalkoxycarbonyl, aryl(lower)alkoxycarbonyl, trialkylsilyl, lower alkylsulfonyl, halogeno(lower)alkylsulfonyl, arylsulfonyl, lower alkylcarbonyl and arylcarbonyl can be used as the protecting group. 
     After protection of the amino group, the compound is subjected to the above-mentioned reactions and the obtained compound is deprotected by treatment of an acid or a base in a suitable solvent at a suitable stage. Examples of a solvent is tetrahydrofuran, dimethylformamide, diethyl ether, dichloromethane, toluene, benzene, xylene, cyclohexane, hexane, chloroform, ethyl acetate, butyl acetate, pentane, heptane, dioxane, acetone, acetonitrile and the mixture thereof. Examples of a base are hydrazine, pyridine, sodium hydroxide and potassium hydroxide and examples of an acid are hydrochloric acid, trifluoroacetic acid and hydrofluoric acid. 
     All of the compounds of the present invention have an NPY Y5 antagonistic activity and the following compounds are specifically preferable. 
     In the formula (I),
     a compound wherein R 1  is optionally substituted lower alkyl or optionally substituted cycloalkyl (hereinafter referred to as “R 1  is R1-1”),   a compound wherein R 1  is C3 to C10 alkyl or C5 to C6 cycloalkyl, each of which is optionally substituted with halogen (hereinafter referred to as “R 1  is R1-2”),   a compound wherein R 1  is C3 to C10 alkyl optionally substituted with halogen (hereinafter referred to as “R 1  is R1-3”),   a compound wherein R 1  is isopropyl or t-butyl (hereinafter referred to as “R 1  is R1-4”),   a compound wherein R 2  is hydrogen or C1 to C3 alkyl (hereinafter referred to as “R 2  is R2-1”),   a compound wherein R 2  is hydrogen (hereinafter referred to as “R 2  is R2-2”),   a compound wherein X is optionally substituted lower alkylene, optionally substituted lower alkenylene or   

     
       
         
         
             
             
         
       
         
         wherein 
       
    
     
       
         
         
             
             
         
       
         
          is optionally substituted cycloalkylene, optionally substituted cycloalkenylene, optionally substituted bicycloalkylene, optionally substituted phenylene or optionally substituted heterocyclediyl (hereinafter referred to as “X is X-1”), 
         a compound wherein X is C2 to C6 alkylene, C3 to C6 alkenylene or 
       
    
     
       
         
         
             
             
         
       
         
         wherein 
       
    
     
       
         
         
             
             
         
       
         
          is optionally substituted cycloalkylene, optionally substituted cycloalkenylene, optionally substituted bicycloalkylene, optionally substituted phenylene, optionally substituted piperidinylene, optionally substituted thiophenediyl or optionally substituted furandiyl (hereinafter referred to as “X is X-2”), 
         a compound wherein X is C2 to C6 alkylene or 
       
    
                         
wherein is optionally substituted cycloalkylene, optionally substituted phenylene, optionally substituted piperidinylene, optionally substituted thiophenediyl or optionally substituted furandiyl (hereinafter referred to as “X is X-3”),
     a compound wherein X is (i) C2 to C6 alkylene or (ii) cycloalkylene or phenylene, each of which is optionally substituted with halogen, hydroxy, lower alkyl or halogeno(lower)alkyl (hereinafter referred to as “X is X-4”),   a compound wherein X is C2 to C6 alkylene or to C5 to C6 cycloalkylene (hereinafter referred to as “X is X-5”),   a compound wherein X is C3 to C6 alkylene or 1,4-cyclohexylene (hereinafter referred to as “X is X-6”),   a compound wherein Y is CONR 7 , CSNR 7 , NR 7 CO or NR 7 CS and R 7  is hydrogen or C1 to C3 alkyl (hereinafter referred to as “Y is Y-1”),   a compound wherein Y is CONH, CSNH or NHCO (hereinafter referred to as “Y is Y-2”),   a compound wherein Y is CONH (hereinafter referred to as “Y is Y-3”),   a compound wherein Z is optionally substituted lower alkyl, optionally substituted carbocyclyl or optionally substituted heterocyclyl (hereinafter referred to as “Z is Z-1”),   a compound wherein Z is —(CR 8 R 9 )r-W-(CR 10 R 11 )s-V
       wherein R 8 , R 9 , R 10  and R 11  are each independently hydrogen or lower alkyl and when Z has two or more of R 8 , two or more of R 9 , two or more of R 10  and for two or more of R 11 , each of R 8 , R 9 , R 10  and R 11  may be different, W is single band, O, S or NR 12 , R 12  is hydrogen, lower alkyl or phenyl, V is hydrogen, optionally substituted cycloalkyl, optionally substituted bicycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl, r is an integer of 1 to 4 and s is an integer of 0 to 4 (hereinafter referred to as “Z is Z-2”),   
       a compound wherein Z is —(CH 2 )r-W—(CH 2 )s-V
       wherein W is single bond, O, S or NR 12 , R 12  is hydrogen or lower alkyl, V is optionally substituted aryl or optionally substituted heterocyclyl wherein the substituents is halogen, hydroxy, lower alkyl, halogeno(lower)alkyl, lower alkoxy, lower alkenyl, amino, lower alkylamino, acyl, carboxy, lower alkoxycarbonyl, phenyl or monocyclic heteroaryl, r is an integer of 1 to 4 and s is an integer of 0 to 4 (hereinafter referred to as “Z is Z-3),   
       a compound wherein Z is —(CH 2 )r-W—(CH 2 )s-V
       wherein W is single bond, O, S, NH or NMe, V is optionally substituted phenyl or optionally substituted heteroaryl wherein the substituents is halogen, lower alkyl, halogeno(lower)alkyl, lower alkoxy, amino or lower alkylamino, r is an integer of 1 to 3 and s is an integer of 0 or 1 (hereinafter referred to as “Z is Z-4”),   
       a compound wherein Z is optionally substituted carbocyclyl,
       wherein the substituent is halogen; hydroxy;   optionally substituted lower alkyl wherein the substituents is halogen, hydroxy, carboxy, lower alkoxycarbonyl, cyano and for phenyl;   lower alkenyl optionally substituted with lower alkoxycarbonyl;   optionally substituted lower alkoxy wherein the substituents is halogen, hydroxy, lower alkoxy, carboxy, lower alkoxycarbonyl, lower alkylamino, cycloalkyl, cyano and/or heterocyclyl;   cycloalkyl; cycloalkyloxy; acyl; lower alkylthio; carbamoyl; lower alkylcarbamoyl; cycloalkylcarbamoyl; hydroxy imino;   optionally substituted amino wherein the substituents is lower alkyl, optionally protected hydroxy(lower)alkyl, lower alkoxy(lower)alkyl, acyl, lower alkylsulfonyl, arylsulfonyl and/or phenyl;   phenyl optionally substituted with halogen, cyano, phenyl and for heterocyclyl;   lower alkylsulfinyl; lower alkylsulfamoyl; cycloalkylsulfamoyl;   nitro; cyano; alkylenedioxy; phenylazo optionally substituted with lower alkyl; phenoxy; oxo;   
       optionally substituted heterocyclyl wherein the substituents is optionally protected hydroxy, mercapto, halogen, lower alkyl, cycloalkyl, lower alkoxycarbonyl, acyl, amino, lower alkoxycarbonylamino, carbamoyl, oxo, phenyl, lower alkoxyphenyl, halogenophenyl, heterocyclyl and/or oxo;   heterocyclylsulfonyl optionally substituted with lower alkyl; heterocyclyloxy;   heterocyclylcarbonyl optionally substituted with lower alkyl (hereinafter referred to as “Z is Z-5),   a compound wherein Z is optionally substituted phenyl
       wherein the substituents is halogen; hydroxy; lower alkyl optionally substituted with halogen, hydroxy, lower alkoxycarbonyl, cyano and/or phenyl; lower alkoxycarbonyl(lower)alkenyl; lower alkoxy optionally substituted with halogen, lower alkoxy, lower alkoxycarbonyl, cycloalkyl and/or heterocyclyl; cycloalkyl;   cycloalkyloxy; acyl; lower alkylthio; carbamoyl; lower alkylcarbamoyl; amino optionally substituted with lower alkyl, hydroxy(lower)alkyl, acyl, lower alkylsulfonyl and/or phenyl; phenyl optionally substituted with halogen, cyano, phenyl and/or heterocyclyl;   lower alkyl sulfamoyl; cycloalkylsulfamoyl; nitro; alkylenedioxy; phenylazo optionally substituted with lower alkyl; phenoxy; oxo;   heterocyclyl optionally substituted with hydroxy, halogen, lower alkyl, lower alkoxycarbonyl, amino, carbamoyl, phenyl, halogenophenyl, heterocyclyl and/or oxo;   heterocyclyloxy; and/or heterocyclylsulfonyl optionally substituted with lower alkyl (hereinafter referred to as “Z is Z-6”),   
       a compound wherein Z is optionally substituted phenyl
       wherein the substituents is halogen; lower alkyl optionally substituted with halogen, hydroxy, lower alkoxycarbonyl and/or phenyl; lower alkoxy optionally substituted with halogen and/or cycloalkyl; cycloalkyl; cycloalkyloxy; acyl; lower alkylthio; lower alkylcarbamoyl; amino optionally substituted with lower alkyl, hydroxy(lower)alkyl, acyl and/or phenyl; phenyl optionally substituted with piperidyl; cycloalkylsulfamoyl;   alkylenedioxy; phenoxy;   morpholinyl or morpholino, each of which is optionally substituted with lower alkyl;   piperidyl optionally substituted with hydroxy, lower alkyl, lower alkoxycarbonyl, phenyl,   halogenophenyl and/or oxo; pyrrolidinyl optionally substituted with hydroxy, carbamoyl and/or oxo;   piperazinyl optionally substituted with phenyl or pyrimidinyl; dihydropyridyl; pyrrolyl;   pyrrolinyl; imidazolyl optionally substituted with halogen and/or lower alkyl; pyrazolyl;   thienyl; thiadiazolyl; furyl; oxazolyl; isoxazolyl; tetrazolyl optionally substituted with lower alkyl and/or phenyl; indolinyl; indolyl; tetrahydroquinolyl; benzothiazolyl optionally substituted with lower alkyl; tetrahydroisothiazolyl optionally substituted with oxo;   benzopyranyl optionally substituted with oxo; tetrahydropyranyloxy; tetrahydrofuryloxy;   morpholinosulfonyl optionally substituted with lower alkyl; and/or piperidylsulfonyl optionally substituted with lower alkyl (hereinafter referred to as “Z is Z-7”),   
       a compound wherein Z is optionally substituted phenyl
       wherein the substituents is halogen, lower alkyl, halogeno(lower)alkyl, lower alkoxy,   cycloalkyloxy, lower alkylcarbamoyl, phenyl, lower alkyl morpholino and/or tetrahydropyranyloxy (hereinafter referred to as “Z is Z-8”),   
       a compound wherein Z is optionally substituted heterocyclyl
       wherein the substituents is halogen, hydroxy, lower alkyl, halogeno(lower)alkyl, lower alkoxy, mercapto, lower alkylthio, acyl, carboxy, lower alkoxycarbonyl, amino, lower alkylamino, phenyl, naphthyl, phenylthio optionally substituted with halogen, phenoxy optionally substituted with halogen, oxo, and/or heterocyclyl optionally substituted with lower alkyl (hereinafter referred to as “Z is Z-9”),   
       a compound wherein Z is thienyl, pyrazolyl, thiazolyl, thiadiazolyl, pyridyl, pyrimidinyl,   pyrazinyl, triazinyl, indolyl, isoindolyl, indolinyl, isoindolinyl, indazolyl, benzopyranyl,   benzothiazolyl, benzothienyl, benzothiazolyl, benzothiazolinyl, benzothiadiazolyl, quinolyl,   isoquinolyl, dihydrobenzofuryl, carbazolyl, acridinyl or dibenzofuryl, each of which is optionally substituted with substituents selected from the group of lower alkyl; halogeno(lower)alkyl; lower alkoxy; lower alkoxycarbonyl; acyl; lower   alkoxycarbonyl(lower)alkyl; mercapto; phenyl, naphthyl, phenylthio or phenoxy, each of which is optionally substituted with halogen; furyl; nitro; oxo; and morpholino optionally substituted with lower alkyl) (hereinafter referred to as “Z is Z-10”),   a compound wherein Z is thienyl, thiazolyl, thiadiazolyl, pyridyl, pyrazinyl, indolyl, isoindolinyl, benzopyranyl, quinolyl, carbazolyl, dibenzofuryl, benzopyranyl, benzothienyl or benzothiazolyl, each of which is optionally substituted with one or more substituents selected from the group of lower alkyl, halogeno(lower)alkyl, lower alkoxy, lower alkoxycarbonyl, acyl, phenyl, naphthyl, phenylthio, lower alkyl morpholino and oxo) (hereinafter referred to as “2 is Z-11),   a compound wherein R 1  is R1-2, R 2  is R2-2, n is 2 and a combination of X, Y and Z, i.e., (X, Y, Z), is any one of the followings.   (X, Y, Z)=(X-3, Y-2, Z-1), (X-3, Y-2, Z-2), (X-3, Y-2, Z-3), (X-3, Y-2, Z-4), (X-3, Y-2, Z-5), (X-3, Y-2, Z-6), (X-3, Y-2, Z-7), (X-3, Y-2, Z-8), (X-3, Y-2, Z-9), (X-3, Y-2, Z-10), (X-3, Y-2, Z-11), (X-3, Y-3, Z-1), (X-3, Y-3, Z-2), (X-3, Y-3, Z-3), (X-3, Y-3, Z-4), (X-3, Y-3, Z-5), (X-3, Y-3, Z-6), (X-3, Y-3, Z-7), (X-3, Y-3, Z-8), (X-3, Y-3, Z-9), (X-3, Y-3, Z-10), (X-3, Y-3, Z-11), (X-4, Y-2, Z-1), (X-4, Y-2, Z-2), (X-4, Y-2, Z-3), (X-4, Y-2, Z-4), (X-4, Y-2, Z-5), (X-4, Y-2, Z-6), (X-4, Y-2, Z-7), (X-4, Y-2, Z-8), (X-4, Y-2, Z-9), (X-4, Y-2, Z-10), (X-4, Y-2, Z-11), (X-4, Y-3, Z-1), (X-4, Y-3, Z-2), (X-4, Y-3, Z-3), (X-4, Y-3, Z-4), (X-4, Y-3, Z-5), (X-4, Y-3, Z-6), (X-4, Y-3, Z-7), (X-4, Y-3, Z-8), (X-4, Y-3, Z-9), (X-4, Y-3, Z-10), (X-4, Y-3, Z-11), (X-5, Y-2, Z-1), (X-5, Y-2, Z-2), (X-5, Y-2, Z-3), (X-5, Y-2, Z-4), (X-5, Y-2, Z-5), (X-5, Y-2, Z-6), (X-5, Y-2, Z-7), (X-5, Y-2, Z-8), (X-5, Y-2, Z-9), (X-5, Y-2, Z-10), (X-5, Y-2, Z-11), (X-5, Y-3, Z-1), (X-5, Y-3, Z-2), (X-5, Y-3, Z-3), (X-5, Y-3, Z-4), (X-5, Y-3, Z-5), (X-5, Y-3, Z-6), (X-5, Y-3, Z-7), (X-5, Y-3, Z-8), (X-5, Y-3, Z-9), (X-5, Y-3, Z-10) or (X-5, Y-3, Z-11),
 
the pharmaceutically acceptable salt, solvate or prodrug thereof.
   

     The NPY Y5 receptor antagonist of the present invention is effective for all of the diseases in which NPY Y5 is involved and it is especially useful for preventing and/or treating obesity and suppressing food intake. Moreover, the antagonist is effective for preventing and/or treating the diseases in which obesity acts as a risk factor, for example, diabetes, hypertension, hyperlipemia atherosclerosis and acute coronary syndrome. 
     In addition, the NPY Y5 receptor antagonist of the present invention has a low affinity for NPY Y1 and Y2 receptors, and has a high selectivity for NPY Y5 receptor. NPY causes a sustained vasoconstrictive action in the periphery and this action is mainly via Y1 receptor. Since Y5 receptor is not involved in this action at all, the NPY Y5 receptor antagonist has a low risk of inducing side effects based on the peripheral vasoconstriction, and is expected to be suitably used as a safe medicine. 
     The NPY Y5 receptor antagonist shows an anti-obestic effect by suppressing food intake. Therefore, it is one of the features that this antagonist does not induce side effects, e.g., an indigestion caused by an anti-obestic agent which inhibits digestion and absorption, and a central side effect such as anti-depression caused by a serotonin transporter inhibitor showing an anti-obesity effect. 
     A compound of the present invention can be administered orally or parenterally as an anti-obestic agent or anorectic agent. In the case of oral administration, it may be in any usual form such as tablets, granules, powders, capsules, pills, solutions, syrups, buccal tablets and sublingual tablets. When the compound is parenterally administered any usual form is preferable, for example, injections (e.g., intravenous, intramuscular), suppositories, endermic gents and vapors. Oral administration is particularly preferable because the compounds of the present invention show a high oral absorbability. 
     A pharmaceutical composition may be manufactured by mixing an effective amount of a compound of the present invention with various pharmaceutical additives suitable for the administration form, such as excipients, binders, moistening agents, disintegrators, lubricants and diluents. When the composition is of an injection, an active ingredient together with a suitable carrier can be sterilized to give a pharmaceutical composition. 
     Examples of the excipients include lactose, saccharose, glucose, starch, calcium carbonate and crystalline cellulose. Examples of the binders include methylcellulose, carboxymethylcellulose, hydroxypropylcellulose, gelatin and polyvinylpyrrolidone. Examples of the disintegrators include carboxymethylcellulose, sodium carboxymethylcellulose, starch, sodium alginate, agar and sodium lauryl sulfate. Examples of the lubricants include talc, magnesium stearate and macrogol. Cacao oil, macrogol, methylcellulose etc. may be used as base materials of suppositories. When the composition is manufactured as solutions, emulsified injections or suspended injections, dissolving accelerators, suspending agents, emulsifiers, stabilizers, preservatives, isotonic agents and the like may be added. For oral administration, sweetening agents, flavors and the like may be added. 
     Although the dosage of a compound of the present invention as an anti-obestic agent or anorectic agent should be determined in consideration of the patient&#39;s age and body weight, the type and degree of diseases, the administration route etc., a usual oral dosage for an adult is 0.05 to 100 mg/kg/day and preferable is 0.1 to 10 mg/kg/day. For parenteral administration, although the dosage highly varies with administration routes, a usual dosage is 0.005 to 10 mg/kg/day, preferably, 0.01 to 1 mg/kg/day. The dosage may be administered in one to several divisions per day. 
     The present invention is further explained by the following Examples and Experiments, which are not intended to limit the scope of the present invention. 
     EXAMPLES 
     Example 1 
     Synthesis of Compound (I-7) 
     
       
         
         
             
             
         
       
     
     Sodium carbonate (995 mg, 9.38 mmol) was dissolved in 30 ml of water and starting material amino acid (1.0 g, 8.53 mmol) and N-carbethoxyphthalimide (2.49 g, 11.4 mmol) were added thereto. The mixture was stirred at room temperature overnight. The pH of the mixture was adjusted to 1 by adding conc. hydrochloric acid. Precipitated crystals were washed with water and dried to give the desired compound (1.72 g, 82% yield). 
       1 H-NMR (CD 3 OD) δ ppm: 1.59-1.77 (m, 4H), 2.34 (t, 2H, J=6.3 Hz), 3.69 (t, 2H, J=6.6 Hz), 7.78-7.87 (m, 4H). 
     
       
         
         
             
             
         
       
     
     The compound obtained in Step 1 (1.0 g, 4.0 mmol) was dissolved in 5 ml of dichloromethane at room temperature. Oxalyl chloride (0.459 ml, 5.2 mmol) and trace amounts of DMF were added to the mixture under ice-cooling and the mixture was reacted under ice-cooling and at room temperature, each for 30 min. After the solvent was removed under reduced pressure, 5 ml of dichloromethane was added. Under ice-cooling, 4-butylaniline (664 mg, 4.4 mmol) and triethylamine (0.564 ml, 4.4 mmol) were added thereto and the mixture was reacted for 30 min. at room temperature. The reactant was poured into water and extracted with chloroform. The organic layer was washed with water and dried over magnesium sulfate anhydride. The solvent was removed under reduced pressure and the residue was purified by silica gel chromatography to give the desired compound (1.49 g, 97% yield). 
       1 H-NMR, (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.27-1.39 (m, 2H), 1.51-1.62 (m, 2H), 1.72-1.84 (m, 4H), 2.40-2.46 (m, 2H), 2.56 (t, 2H, J=7.5 Hz), 3.76 (t, 1H, J=5.7 Hz), 7.12 (d, 2H, J=7.8 Hz), 7.33 (s, 1H), 7.42 (d, 2H, J=8.1 Hz), 7.71-7.73 (m, 2H), 7.83-7.86 (m, 2H). 
     
       
         
         
             
             
         
       
     
     After the compound obtained in Step 2 (1.49 g, 3.9 mmol) was dissolved in 30 ml of ethanol, hydrazine monohydrate (0.591 mg, 11.8 mmol) was added and the mixture was reacted at 50° C. for 3 hours. The solvent was removed, 1 mol/l aqueous NaOH was added and the solution was extracted with ethyl acetate. The organic layer was washed with water and dried over magnesium sulfate anhydride. The solvent was removed under reduced pressure to give the desired compound (808 mg, 83% yield) 
       1 H-NMR (CD 3 OD) δ ppm: 0.93 (t, 3H, J=7.2 Hz), 1.28-1.40 (m, 2H), 1.50-1.62 (m, 4H), 1.67-1.77 (m, 2H), 2.37 (t, 2H, J=7.5 Hz), 2.56 (t, 2H, J=7.8 Hz), 2.68 (t, 2H, J=7.2 Hz), 7.11 (d, 2H, J=8.1 Hz), 7.42 (d, 2H, J=8.4 Hz). 
     
       
         
         
             
             
         
       
     
     The compound obtained in Step 3 (808 mg, 3.25 mmol) was suspended in 5 ml of dichloromethane under ice-cooling and isopropylsulfonyl chloride (696 mg, 4.9 mmol) and triethylamine (494 mg, 4.9 mmol) were added. After the mixture was reacted under ice-cooling for an hour, the reactant was poured into water and extracted with chloroform. The organic layer was washed with water and dried over magnesium sulfate anhydride. The solvent was removed under reduced pressure and the residue was purified by silica gel chromatography to give the desired compound quantitatively.  1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.27-1.40 (m, 2H), 1.36 (d, 6H, J=6.6 Hz), 1.51-1.69 (m, 4H), 1.77-1.86 (m, 2H), 2.38 (t, 2H, J=7.2 Hz), 2.56 (t, 2H, J=7.5 Hz), 3.12-3.21 (m, 3H), 4.38 (t, 1H, J=5.7 Hz), 7.11 (d, 2H, J=8.4 Hz), 7.36-7.41 (m, 3H). 
     Example 2 
     Synthesis of Compound (I-10) 
     
       
         
         
             
             
         
       
     
     The desired compound was synthesized in a similar manner to Step 4 in Example 1 except that tert-butylsulfinyl chloride (689 mg, 4.9 mmol) and triethylamine (494 mg, 4.9 mmol) were added to the compound obtained in Step 3 in Example 1. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.22 (s, 9H), 1.30-1.37 (m, 2H), 1.51-1.68 (m, 4H), 1.76-1.86 (m, 2H), 2.31-2.40 (m, 2H), 2.56 (t, 2H, J=7.5 Hz), 3.15-3.26 (m, 3H), 7.11 (t, 2H, J=8.7 Hz), 7.42 (d, 2H, J=8.1 Hz), 7.54 (s, 1H). 
     Example 3 
     Synthesis of Compound (I-11) 
     
       
         
         
             
             
         
       
     
     The compound obtained in Example 2 (352 mg, 1.0 mmol) was dissolved in 5 ml of dichloromethane under ice-cooling and mCPBA (259 mg, 1.5 mmol) was added to the solution. The solution was reacted at room temperature for an hour and the insoluble material was filtered off. The filtrate was washed with 1 mol/l NaOH, Na 2 S 2 O 5  and water, successively, and dried over magnesium sulfate anhydride. The solvent was removed under reduced pressure and the residue was purified by silica gel chromatography to give the desired compound (338 mg, 92% yield). 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.29-1.39 (m, 2H), 1.39 (s, 9H), 1.51-1.68 (m, 4H), 1.76-1.84 (m, 2H), 2.37 (t, 2H, J=7.5 Hz), 2.56 (t, 2H, J=7.8 Hz), 3.19-3.26 (m, 2H), 4.20 (t, 1H, J=5.7 Hz), 7.11 (t, 2H, J=8.1 Hz), 7.42 (d, 2H, J=8.7 Hz), 7.46 (s, 1H). 
     Example 4 
     Synthesis of Compound (I-72) 
     
       
         
         
             
             
         
       
     
     Starting material amino acid (a mixture of cis isomer and trans isomer) (1.0 g, 8.53 mmol) was dissolved in 7.5 ml of methanol. Thionyl chloride (1.0 ml, 13.7 mmol) was added to the mixture under ice-cooling and the mixture was stirred at room temperature overnight. After the mixture was concentrated under reduced pressure, diethylether was added and precipitated crystals were obtained by filtration. The crystals were washed with diethylether and dried to give the desired compound (1.25 g, 93% yield). 
       1 H-NMR (CDCl 3 ) δ ppm: 1.50-2.60 (m, 9H), 3.08-3.36 (m, 1H), 3.67 (s, 3H, CO 2 Me of cis isomer), 3.71 (s, 3H, CO 2 Me of trans isomer), 8.15-8.55 (m, 3H). 
     
       
         
         
             
             
         
       
     
     The desired sulfonamide (a mixture of cis isomer and trans isomer) was synthesized from starting material methyl ester in similar manners to Step 3 in Example 1 and Example 2. 
     Cis isomer 
       1 H-NMR (CDCl 3 ) δ ppm: 1.39 (s, 9H), 1.52-1.99 (m, 8H), 2.43-2.53 (m, 1H), 3.42-3.55 (m, 1H), 3.69 (s, 3H), 3.85 (d, 1H, J=9.0 Hz). 
     
       
         
         
             
             
         
       
     
     Starting material sulfonamide (19.4 g, 70.0 mmol, a mixture of cis isomer and trans isomer) was dissolved in 30 ml of methanol. To the mixture, 28% sodium methoxide (284 ml, 140.0 mmol) was added and refluxed with stirring under ice-cooling. After the solvent was removed, the residue was diluted with chloroform, and 1 mol/l HCl was added with stirring under ice-cooling until pH of an aqueous layer reached 3. The aqueous layer was extracted with chloroform and the organic layer was washed with water and dried over magnesium sulfate anhydride. The obtained crude crystals were recrystallized from hexane-ethyl acetate to give the desired sulfonamide (trans isomer, 7.75 g, 40% yield). 
     Trans isomer 
       1 H-NMR (CD 3 OD) δ ppm: 1.16-1.32 (m, 2H), 1.39 (s, 9H), 1.44-1.52 (m, 2H), 1.98-2.09 (m, 2H), 2.14-2.29 (m, 3H), 3.18-3.37 (m, 1H), 3.63 (d, 1H, J=9.0 Hz), 3.67 (s, 3H). 
     
       
         
         
             
             
         
       
     
     Starting material methyl ester (4.77 g, 17.2 mmol) was dissolved in 95 ml of methanol and 1 mol/l NaOH (43 ml, 43.0 mmol) was added with stirring under ice-cooling. The mixture was stirred at room temperature overnight and concentrated under reduced pressure. After 1 mol/l HCl was added with stirring until pH of the mixture reached 3 under ice-cooling, the precipitated crystals were collected by filtration, washed with water and dried. The obtained crude crystals were recrystallized from hexane-ethylacetate to give the desired carboxylic acid (4.20 g, 93% yield). 
       1 H-NMR (CDCl 3 ) δ ppm: 1.18-1.35 (m, 2H), 1.39 (s, 91-1, 1.46-1.63 (m, 2H), 2.01-2.14 (m, 2H), 2.14-2.32 (m, 3H), 3.18-3.35 (m, 1H), 3.80 (d, 1H, J=9.6 Hz). 
     
       
         
         
             
             
         
       
     
     A starting material carboxylic acid (5.86 g, 22.3 mmol) was dissolved in 88 ml of dichloromethane at room temperature. To the mixture, oxalyl chloride (2.34 ml, 26.7 mmol) and catalytic amount of DMF were added under ice-cooling and stirred at room temperature for an hour. After the solvent was removed under reduced pressure, dichloromethane (115 ml), substituted aniline (5.05 g, 24.5 mmol) and triethylamine (4.65 ml, 33.4 mmol) were added. The mixture was stirred at room temperature for 2.5 hours, the ice-cooling water was poured thereto, and the mixture was extracted with chloroform. An organic layer was washed with water and dried over magnesium sulfate anhydride. The solvent was removed under reduced pressure and ethyl acetate and hexane were added to the residue. The precipitated crystals were collected with filtration to give the desired amide (7.00 g, 70% yield). 
       1 H-NMR (CDCl 3 ) δ ppm: 1.25 (d, 6H, J=6.3 Hz), 1.17-1.42 (m, 2H), 1.40 (s, 9H), 1.60-1.78 (m, 2H), 1.98-2.43 (m, 7H), 3.20-3.43 (m, 3H), 3.67 (d, 1H, J=9.6 Hz), 3.74-3.86 (m, 2H), 6.86 (d, 2H, J=9.0 Hz), 7.04 (s, 1H), 7.38 (d, 2H, J=9.0 Hz). 
     Example 5 
     Synthesis of Compound (I-2) 
     
       
         
         
             
             
         
       
     
     After starting material diamine (461 mg, 2.5 mmol) was suspended in dichloromethane under ice-cooling, an acid chloride (500 mg, 2.5 mmol) and triethylamine (773 mg, 7.5 mmol) were added and the mixture was reacted for 30 min. Water and dichloromethane were added to the reactant and insoluble materials were filtered off. The organic layer was washed with water and dried over magnesium sulfate anhydride. The solvent was removed under reduced pressure to give the desired compound as a residue (100 mg, 15% yield). 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.2 Hz), 1.30-1.42 (m, 2H), 1.57-1.67 (m, 2H), 2.66 (t, 2H, J=7.8 Hz), 3.50 (brs, 1H), 6.57 (s, 1H), 6.68 (d, 2H, J=8.7 Hz), 7.26 (d, 2H, J=8.4 Hz), 7.39 (d, 2H, J=8.7 Hz), 7.68 (s, 1H), 7.75 (d, 2H, J=8.1 Hz). 
     
       
         
         
             
             
         
       
     
     The desired compound was synthesized in a similar manner to Step 4 in Example 1. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.94 (t, 3H, J=7.5 Hz), 1.34-1.44 (m, 2H), 1.40 (d, 6H, J=6.6 Hz), 1.59-1.68 (m, 2H), 2.69 (t, 2H, J=7.8 Hz), 3.24-3.35 (m, 1H), 6.49 (s, 1H), 7.23-7.32 (m, 4H), 7.6 (d, 2H, J=8.7 Hz), 7.79 (d, 2H, J=8.1 Hz), 7.85 (s, 1H). 
     Example 6 
     Synthesis of Compound (I-31) 
     
       
         
         
             
             
         
       
     
     A starting material diamine (8.37 g, 73.3 mmol) was dissolved in 30 ml of dioxane at room temperature and a solution of Boc 2 O (2 g, 9.2 mmol) in dioxane (30 ml) was added. The mixture was reacted at room temperature for 3 days and the solvent was removed. Water was added to the residue and the mixture was extracted with chloroform. The organic layer was washed with water and dried over magnesium sulfate anhydride. The solvent was removed under reduced pressure to give the desired compound as a residue (1.8 g, 92% yield based on Boc 2 O) 
       1 H-NMR (CDCl 3 ) δ ppm: 1.07-1.26 (m, 9H), 1.44 (s, 9H), 1.84-2.00 (m, 4H), 2.58-2.67 (m, 1H), 3.37 (brs, 1H), 4.43 (brs, 1H). 
     
       
         
         
             
             
         
       
     
     The desired compound was synthesized in a similar manner to Step 1 in Example 5. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.2 Hz), 1.26-1.42 (m, 6H), 1.45 (s, 9H), 1.54-1.68 (m, 2H), 1.99-2.12 (m, 4H), 2.64 (t, 2H, J=7.8 Hz), 3.4.3 (brs, 1H), 3.90-4.00 (m, 1H), 4.48 (d, 1H, J=5.7 Hz), 5.95 (d, 1H, J=8.4 Hz), 7.21 (d, 2H, J=8.4 Hz), 7.65 (d, 2H, J=8.4 Hz). 
     
       
         
         
             
             
         
       
     
     A starting material Boc compound (2.08 g, 5.55 mmol) was dissolved in 20 ml of ethyl acetate under ice-cooling and 20 ml of 4 mol/l HCl/AcOEt was added. The mixture was reacted at room temperature for an hour and the solvent was removed under reduced pressure to give the desired compound as a residue (1.7 g, 98% yield). 
       1 H-NMR (CD 3 OD) δ ppm: 0.93 (t, 3H, J=7.2 Hz), 1.29-1.41 (m, 2H), 1.50-1.66 (m, 6H), 2.02-2.18 (m, 4H), 2.66 (t, 2H, J=7.8 Hz), 3.13 (brs, 1H), 3.82-3.94 (m, 1H), 7.26 (d, 2H, J=8.7 Hz), 7.72 (d, 2H, J=8.4 Hz). 
     
       
         
         
             
             
         
       
     
     The desired compound was synthesized in a similar manner to Step 4 in Example 1. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.5 Hz), 1.21 (s, 9H), 1.28-1.62 (m, 8H), 2.07-2.14 (m, 4H), 2.64 (t, 2H, J=7.8 Hz), 3.11 (d, 1H, J=5.1 Hz), 3.20 (brs, 1H), 3.90-4.04 (m, 1H), 6.06-6.14 (m, 1H), 7.21 (t, 2H, J=8.1 Hz), 7.67 (t, 2H, J=8.4 Hz). 
     Example 7 
     Synthesis of Compound (I-32) 
     
       
         
         
             
             
         
       
     
     The desired compound was synthesized from the compound obtained in Example 6 in a similar manner to Example 3. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.2 Hz), 1.27-1.65 (m, 8H), 1.40 (s, 9H), 2.10-2.23 (m, 4H), 2.65 (t, 2H, J=7.5 Hz), 3.23-3.35 (m, 1H), 3.49 (s, 1H), 3.88-4.02 (m, 1H), 5.84-5.92 (m, 1H), 7.13 (t, 2H, J=8.4 Hz), 7.65 (d, 2H, J=8.1 Hz). 
     Example 8 
     Synthesis of Compound (I-5) 
     
       
         
         
             
             
         
       
     
     The desired compound was synthesized in a similar manner to Step 2 in Example 1. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.94 (t, 3H, J=7.5 Hz), 1.30-1.42 (m, 2H), 1.50-1.65 (m, 2H), 2.61 (t, 2H, J=7.8 Hz), 7.20 (d, 2H, J=7.2 Hz), 7.48-7.51 (m, 3H), 7.72 (s, 1H), 7.88-7.90 (m, 1H). 
     
       
         
         
             
             
         
       
     
     To a mixture of a starting material nitro compound (593 mg, 1.95 mmol) and tin (358 mg, 3.0 mmol), 30 ml of 6 mol/l HCl and 6 ml of THF were added and reacted at 50° C. for 3 hours. After cooling, the solvent was removed and the residue was neutralized 10% with NaOH and extracted with chloroform. The organic layer was washed with water and dried over magnesium sulfate anhydride. The solvent was removed under reduced pressure and the residue was purified by silica gel chromatography to give the desired compound (110 mg, 21% yield). 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.26-1.39 (m, 2H), 1.49-1.59 (m, 2H), 2.50 (t, 2H, J=7.8 Hz), 4.37 (s, 1H), 6.65 (d, 2H, J=8.4 Hz), 6.97 (d, 2H, J=8.4 Hz), 7.14 (d, 1H, J=8.4 Hz), 7.43 (d, 1H, J=8.7 Hz). 
     
       
         
         
             
             
         
       
     
     The desired compound was synthesized in a similar manner to Step 4 in Example 1. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.2 Hz), 1.28-1.41 (m, 2H), 1.46 (d, 6H, J=6.9 Hz), 1.53-1.63 (m, 2H), 2.59 (t, 2H, J=7.8 Hz), 3.35-3.44 (m, 1H), 7.15 (d, 2H, J=8.7 Hz), 7.38 (s, 1H), 7.45 (d, 2H, J=8.7 Hz), 7.57 (s, 1Hz), 
     Example 9 
     Synthesis of Compound (I-4) 
     
       
         
         
             
             
         
       
     
     The desired compound was synthesized in a similar manner to Step 4 in Example 1. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.44 (d, 6H, J=6.9 Hz), 3.33-3.43 (m, 1H), 3.88 (s, 9H), 6.24-6.36 (m, 1H), 7.11-7.14 (m, 2H). 
     
       
         
         
             
             
         
       
     
     The desired compound was synthesized in a similar manner to Step 4 in Example 4. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.44 (d, 6H, J=6.3 Hz), 3.33-3.45 (m, 1H), 6.25-6.28 (m, 1H), 7.27-7.28 (m, 1H), 7.51 (s, 1H). 
     
       
         
         
             
             
         
       
     
     The desired compound was synthesized in a similar manner to Step 2 in Example 1. 
       1 H-NMR (CD 3 OD) δ ppm: 0.92 (t, 3H, J=6.9 Hz), 1.28-1.41 (m, 2H), 1.46 (d, 6H, J=6.3 Hz), 1.53-1.63 (m, 2H), 2.58 (t, 2H, J=7.8 Hz), 3.33-3.43 (m, 1H), 6.27-6.29 (m, 1H), 7.14-7.16 (m, 3H), 7.50 (d, 2H, J=8.4 Hz), 7.90 (s, 1H). 
     Example 10 
     Synthesis of Compound (I-28) 
     
       
         
         
             
             
         
       
     
     The desired compound was synthesized in a similar manner to Step 1 in Example 1. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.37-1.52 (m, 3H), 1.74-4.79 (m, 2H), 2.07-2.13 (m, 2H), 2.28-2.42 (m, 2H), 3.72-3.81 (m, 1H), 4.09-4.20 (m, 1H), 7.68-7.73 (m, 2H), 7.81-7.85 (m, 2H). 
     
       
         
         
             
             
         
       
     
     4-butylphenyl isocyanate (2.85 g, 16.3 mmol) was dissolved in 30 ml of THF, and a starting material alcohol (1.0 g, 4.08 mmol) and bis(tributyltin)oxide (972 mg, 1.63 mmol) were added. After the mixture was stirred overnight, the solvent was removed, water was added and the solution was extracted with chloroform. The organic layer was washed with water and dried over magnesium sulfate anhydride. The solvent was removed under reduced pressure and the residue was purified by silica gel chromatography to give the desired compound (332 mg, 19% yield). 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=6.9 Hz), 1.30-1.40 (m, 2H), 1.48-1.62 (m, 4H), 1.79-1.83 (m, 2H), 2.21-2.25 (m, 2H), 2.37-2.50 (m, 2H), 2.57 (t, 2H, J=7.8 Hz), 4.11-4.22 (m, 1H), 4.77-4.87 (m, 1H), 6.49 (s, 1H), 7.11 (d, 2H, J=8.7 Hz), 7.28 (d, 2H, J=8.7 Hz), 7.69-7.73 (m, 2H), 7.80-7.84 (m, 2H). 
     
       
         
         
             
             
         
       
     
     The desired compound was synthesized in similar manners to Step 3 in Example 1 and Example 2. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.21 (s, 9H), 1.30-4.62 (m, 8H), 2.08 (d, 4H, J=11.1 Hz), 2.56 (t, 2H, J=7.8 Hz), 3.04 (d, 1H, J=4.8 Hz), 3.20-3.30 (m, 1H), 4.65-4.76 (m, 1H), 6.57 (s, 1H), 7.10 (d, 2H, J=8.7 Hz), 7.26 (d, 2H, J=8.1 Hz). 
     Example 11 
     Synthesis of Compound (I-29) 
     
       
         
         
             
             
         
       
     
     The desired compound was synthesized in a similar manner to Example 3. 
       1 H NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.23-1.62 (m, 8H), 1.40 (s, 9H), 2.12 (d, 4H, J=14.4 Hz), 2.56 (t, 2H, J=7.8 Hz), 3.28-3.40 (m, 1H), 3.90 (s, 1H), 4.60-4.73 (m, 1H), 6.57 (s, 1H), 7.10 (d, 2H, J=8.4 Hz), 7.25 (d, 2H, J=8.4 Hz). 
     Example 12 
     Synthesis of Compound (I-114) 
     
       
         
         
             
             
         
       
     
     Lawesson&#39;s reagent [2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide] (132 mg) was added to a solution of 100 mg of Compound (I-110) synthesized in a similar manner to Example 1 in toluene (2.7 ml) and the mixture was stirred at 80° C. for 3 hours. The reactant was concentrated under reduced pressure and the residue was purified by silica gel chromatography (ethyl acetate: n-hexane=1:1) to give pale yellow crystals (82.3 mg, 79%). The crystals were recrystallized from methylene chloride-diisopropyl ether to give the desired compound as colorless needles (50.5 mg, 48%). 
     Example 13 
     Synthesis of Compound (I-120) 
     
       
         
         
             
             
         
       
     
     Ethyl 4-amino-1-piperidinecarboxylate (300 mg) and triethylamine (258 mg) were dissolved in 5 ml of dichloromethane. To the mixture, 2 ml of solution of t-butylsulfinyl chloride (222 mg) in dichloromethane was added and the mixture was stirred at room temperature for 4 hours. The solution was partitioned into an aqueous solution of potassium hydrogen sulfate and ethyl acetate. The organic layer was washed with brine and dried over magnesium sulfate anhydride. The solvent was removed under reduced pressure and the residue was purified by silica gel chromatography to give 378 mg of 4-t-butylsulfinylamino-1-ethoxycarbonyl piperidine. 
     
       
         
         
             
             
         
       
     
     In a mixture of 5 ml of 2-propanol and 5 ml of water, 378 mg of 4-t-butylsulfinylamino-1-ethoxycarbonyl piperidine was suspended and 1.77 g of barium hydroxide was added. The mixture was refluxed with stirring and heating for 4 hours. The mixture was diluted with methanol and the insoluble material was filtered off. The solvent was removed under reduced pressure to give 4-t-butylsulfinylaminopiperidine. Without purification, the obtained material was dissolved in 5 ml of THF, and 984 mg of N-phenoxycarbonyl-4-butyl aniline and 236 mg of diisopropyl ethylamine were added, followed by stirring at room temperature overnight. An aqueous solution of potassium hydrogen sulfate was added to the mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over magnesium sulfate anhydride. The solvent was removed under reduced pressure and the residue was purified by silica gel chromatography to give 291 mg of 4-t-butylsulfinylaminopiperidine-1-carboxylic acid(4-t-butylphenyl)amide. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.89 (t, 3H, J=7.3 Hz), 1.19 (s, 9H), 1.25-1.38 (m, 4H), 1.40-1.60 (m, 4H), 1.89-2.03 (m, 3H), 2.52 (t, 2H, J=7.7 Hz), 2.89-3.04 (m, 2H), 3.14 (d, 1H, J=5.2 Hz), 3.37 (m, 1H), 3.96 (m, 2H), 6.67 (s, 1H), 7.05 (d, 2H, J=8.5 Hz), 7.22 (d, 2H, J=8.5 Hz). 
     
       
         
         
             
             
         
       
     
     In a mixture of 2 ml of methanol and 2 ml of methylene chloride, 291 mg of 4-t-butylsulfinylaminopiperidine-1-carboxylic acid(4-t-butylphenyl)amide was dissolved. To the mixture, 570 mg of 80%-MMPP (magnesium monoperoxyphthalate hexahydrate) was added and the mixture was stirred at room temperature for 2 hours. The solution was diluted with water and extracted with ethyl acetate. The organic layer was washed with brine and dried over magnesium sulfate anhydride. The solvent was removed under reduced pressure and the residue was purified by silica gel chromatography to give 130 mg of 4-t-butylsulfonylaminopiperidine-1-carboxylic acid(4-butylphenyl)amide (I-120). 
     Other Compounds (I) are synthesized by the similar methods. The structures and physical properties are shown below. 
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
I-2
 
       1 H-NMR (CDCl 3 ) δ ppm: 0.94 (t, 3H, J=7.5 Hz), 1.34-1.44 (m, 2H), 1.40 (d, 6H, J=6.6 Hz), 1.59-1.68 (m, 2H), 2.69 (t, 2H, J=7.8 Hz), 3.24-3.35 (m, 1H), 6.49 (s, 1H), 7.23-7.32 (m, 4H), 7.6 (d, 2H, J=8.7 Hz), 7.79 (d, 2H, J=8.1 Hz), 7.85 (s, 1H). 
     I-3 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.2 Hz), 1.30-1.39 (m, 2H), 1.37 (d, 6H, J=6.9 Hz), 1.57 (quint, 2H, J=7.5 Hz), 1.96 (quint, 2H, J=6.6 Hz), 2.49 (t, 2H, J=6.6 Hz), 2.57 (t, 2H, J=7.8 Hz), 3.16-3.26 (m, 3H), 4.62 (brs, 1H), 7.12 (d, 2H, J=8.1 Hz), 7.43 (d, 2H, J =8.4 Hz), 7.64 (s, 1H). 
     I-4 
       1 H-NMR (CD 3 OD) δ ppm: 0.92 (t, 3H, J=6.9 Hz), 1.28-1.41 (m, 2H), 1.46 (d, 6H, J=6.3 Hz), 1.53-1.63 (m, 2H), 2.58 (t, 2H, J=7.8 Hz), 3.33-3.43 (m, 1H), 6.27-6.29 (m, 1H), 7.14-7.16 (m, 3H), 7.50 (d, 2H, J=8.4 Hz), 7.90 (s, 1H). 
     I-5 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.2 Hz), 1.28-1.41 (m, 2H), 1.46 (d, 6H, J=6.9 Hz), 1.53-1.63 (m, 2H), 2.59 (t, 2H, J=7.8 Hz), 3.35-3.44 (m, 1H), 7.15 (d, 2H, J=8.7 Hz), 7.38 (s, 1H), 7.45 (d, 2H, J=8.7 Hz), 7.57 (s, 1H). 
     I-6 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.29-1.39 (m, 2H), 1.37 (d, 6H, J=6.9 Hz), 1.55 (quint, 2H, J=7.5 Hz), 2.55 (t, 2H, J=5.1 Hz), 3.18-3.27 (m, 1H), 3.92 (d, 2H, J=6.0 Hz), 5.51 (t, 1H, J=5.7 Hz), 7.10 (d, 2H, J=8.4 Hz), 7.39 (d, 2H, J=8.4 Hz), 8.23 (s, 1H). 
     I-7 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.28-1.88 (m, 2H), 1.37 (d, 6H, J=6.9 Hz), 1.51-1.67 (m, 4H), 1.78-1.88 (m, 2H), 2.39 (t, 2H, J=7.2 Hz), 2.57 (t, 2H, J=7.5 Hz), 3.12-3.22 (m, 3H), 4.30-4.37 (m, 1H), 7.12 (d, 2H, J=8.4 Hz), 7.36-7.42 (m, 3H). 
     I-8 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.21-1.47 (m, 4H), 1.35 (d, 6H, J=6.6 Hz), 1.51-1.63 (m, 4H), 1.67-1.77 (m, 2H), 2.34 (t, 2H, J=7.5 Hz), 2.55 (t, 2H, J=7.8 Hz), 3.08-3.17 (m, 3H), 4.71 (t, 1H, J=6.0 Hz), 7.09 (d, 2H, J=8.1 Hz), 7.43 (d, 2H, J=8.4 Hz), 7.74 (s, 1H). 
     I-9 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.29-1.39 (m, 2H), 1.35 (d, 6H, J=6.9 Hz), 1.50-1.60 (m, 2H), 2.54 (t, 2H, J=7.8 Hz), 2.64 (t, 2H, J=5.7 Hz), 3.14-3.23 (m, 1H), 3.41-3.47 (m, 2H), 5.29 (t, 1H, J=6.3 Hz), 7.10 (d, 2H, J=8.4 Hz), 7.39 (d, 2H, J=8.4 Hz), 7.91 (s, 1H). 
     I-10 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.22 (s, 9H), 1.30-1.37 (m, 2H), 1.51-1.68 (m, 4H), 1.76-1.86 (m, 2H), 2.31-2.40 (m, 2H), 2.56 (t, 2H, J=7.5 Hz), 3.15-3.26 (m, 3H), 7.11 (t, 2H, J=8.7 Hz), 7.42 (d, 2H, J=8.1 Hz), 7.54 (s, 1H). 
     I-11 
     mp: 128-129° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.29-1.39 (m, 2H), 1.39 (s, 9H), 1.51-1.68 (m, 4H), 1.76-1.84 (m, 2H), 2.37 (t, 2H, J=7.5 Hz), 2.56 (t, 2H, J=7.8 Hz), 3.19-3.26 (m, 2H), 4.20 (t, 1H, J=5.7 Hz), 7.11 (d, 2H, J=8.1 Hz), 7.42 (d, 2H, J=8.7 Hz), 7.46 (s, 1H). 
     I-12 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.28-1.37 (m, 2H), 1.47-1.68 (m, 6H), 2.23 (t, 2H, J=7.2 Hz), 2.56 (t, 2H, J=7.5 Hz), 2.90-2.97 (m, 2H), 5.10 (brs, 1H), 7.11 (d, 2H, J=8.4 Hz), 7.36 (d, 2H, J=8.1 Hz), 7.50-7.68 (m, 3H), 7.93 (d, 1H, J=8.1 Hz), 8.06 (d, 1H, J=8.4 Hz), 8.24 (d, 1H, J=7.5 Hz), 8.66 (d, 1H, J=8.7 Hz). 
     I-13 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.28-1.40 (m, 2H), 1.45-1.73 (m, 6H), 2.23 (t, 2H, J=7.5 Hz), 2.56 (t, 2H, J=7.8 Hz), 2.88 (s, 6H), 2.88-2.95 (m, 2H), 5.04 (brs, 1H), 7.10 (d, 2H, J=8.1 Hz), 7.17 (d, 1H, J=7.2 Hz), 7.37 (d, 2H, J=8.4 Hz), 7.48-7.54 (m, 2H), 8.23 (d, 1H, J=7.2 Hz), 8.30 (d, 1H, J=8.7 Hz), 8.53 (d, 1H, J=8.4 Hz), 
     I-14 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.30-1.43 (m, 6H), 1.36 (d, 6H, J=6.6 Hz), 1.51-1.62 (m, 4H), 1.67-1.78 (m, 2H), 2.34 (t, 2H, J=7.5 Hz), 2.56 (t, 2H, J=7.8 Hz), 3.09-3.20 (m, 3H), 4.34 (brs, 1H), 7.10 (d, 2H, J=8.4 Hz), 7.41-7.44 (m, 3H). 
     I-15 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.23 (s, 9H), 1.27-1.80 (m, 12H), 2.30-2.38 (m, 2H), 2.56 (t, 2H, J=7.5 Hz), 3.15 (brs, 2H), 7.11 (d, 2H, J=7.8 Hz), 7.43 (d, 2H, J=7.8 Hz), 7.59 (s, 1H). 
     I-16 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.29-1.44 (m, 6H), 1.39 (s, 9H), 1.51-1.61 (m, 4H), 1.68-1.78 (m, 2H), 2.35 (t, 2H, J=7.5 Hz), 2.56 (t, 2H, J=8.1 Hz), 3.15-3.21 (m, 2H), 4.14-4.23 (m, 1H), 7.11 (d, 2H, J=7.8 Hz), 7.36-7.44 (m, 3H). 
     I-19 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.5 Hz), 1.21 (s, 9H), 1.30-1.40 (m, 2H), 1.55-1.72 (m, 6H), 2.64 (t, 2H, J=7.8 Hz), 3.08-3.33 (m, 3H), 3.42-3.50 (m, 2H), 6.39 (s, 1H), 7.22 (d, 2H, J=8.4 Hz), 7.69 (d, 2H, J=8.1 Hz). 
     I-20 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.2 Hz), 1.31-1.39 (m, 2H), 1.39 (s, 9H), 1.55-1.72 (m, 6H), 2.64 (t, 2H, J=7.8 Hz), 3.24 (quart, 2H, J=6.6 Hz), 3.48 (quart, 2H, J=6.6 Hz), 4.21 (t, 1H, J=6.3 Hz), 6.29 (s, 1H), 7.22 (d, 2H, J=7.8 Hz), 7.67 (d, 2H, J=8.1 Hz). 
     I-21 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.23 (s, 9H), 1.30-1.42 (m, 2H), 1.50-2.02 (m, 10H), 2.30-2.42 (m, 1H), 2.57 (t, 2H, J=8.1 Hz), 3.10 (brs, 1H), 3.57 (brs, 1H), 7.12 (d, 2H, J=8.4 Hz), 7.41 (d, 2H, J=7.8 Hz). 
     I-22 
     mp: 78-79° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.30-1.40 (m, 2H), 1.40 (s, 9H), 1.50-1.65 (m, 4H), 1.70-1.98 (m, 8H), 2.30-2.40 (m, 1H), 2.57 (t, 2H, J=7.5 Hz), 3.58-3.70 (m, 1H), 4.16 (d, 1H, J=9.3 Hz), 7.11-7.15 (m, 3H), 7.40 (d, 2H, J=8.1 Hz). 
     I-23 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.21 (s, 9H), 1.21-1.41 (m, 4H), 1.51-1.64 (m, 4H), 1.86-2.01 (m, 4H), 2.12-2.25 (m, 1H), 2.56 (t, 2H, J=7.5 Hz), 2.87-2.96 (m, 1H), 3.00-3.12 (m, 1H), 3.23-3.34 (m, 1H), 3.67-3.75 (m, 1H), 7.11 (d, 2H, J=8.1 Hz), 7.40 (d, 2H, J=8.4 Hz). 
     I-24 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.25-1.37 (m, 2H), 1.40 (s, 9H), 1.48-1.65 (m, 6H), 1.90 (d, 2H, J=11.7 Hz), 2.02 (d, 2H, J=11.7 Hz), 2.12-2.24 (m, 1H), 2.56 (t, 2H, J=7.5 Hz), 3.04 (t, 2H, J=6.3 Hz), 4.31 (t, 1H, J=5.7 Hz), 7.11 (d, 2H, J=8.1 Hz), 7.42 (d, 2H, J=8.4 Hz). 
     I-25 
     mp: 232-233° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.23-1.40 (m, 4H), 1.40 (s, 9H), 1.51-1.76 (m, 4H), 2.01-2.26 (m, 5H), 2.56 (t, 2H, J=7.5 Hz), 3.22-3.38 (m, 1H), 3.79 (d, 1H, J=9.3 Hz), 7.11 (d, 2H, J=8.7 Hz), 7.17 (s, 1H), 7.40 (d, 2H, J=8.4 Hz). 
     I-26 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.22 (s, 9H), 1.28-1.40 (m, 2H), 1.52-1.62 (m, 2H), 1.85-1.96 (m, 1H), 2.00-2.14 (m, 1H), 2.38-2.53 (m, 2H), 2.56 (t, 2H, J=7.5 Hz), 3.22-3.37 (m, 3H), 7.11 (d, 2H, J=8.4 Hz), 7.45 (d, 2H, J=8.4 Hz), 8.19 (s, 1H). 
     I-27 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.30-1.40 (m, 2H), 1.40 (s, 9H), 1.52-1.61 (m, 2H), 1.95 (quint, 2H, J=6.3 Hz), 2.50 (t, 2H, J=6.9 Hz), 2.56 (t, 2H, J=7.8 Hz), 3.31 (quart, 2H, J=6.0 Hz), 4.30-4.36 (m, 1H), 7.12 (d, 2H, J=8.4 Hz), 7.43 (d, 2H, J =8.4 Hz), 7.65 (s, 1H). 
     I-28 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.21 (s, 9H), 1.30-1.62 (m, 8H), 2.08 (d, 4H, J=11.1 Hz), 2.56 (t, 2H, J=7.8 Hz), 3.04 (d, 1H, J=4.8 Hz), 3.20-3.30 (m, 1H), 4.65-4.76 (m, 1H), 6.57 (s, 1H), 7.10 (d, 2H, J=8.7 Hz), 7.26 (d, 2H, J=8.1 Hz). 
     I-29 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.2 Hz), 1.23-1.62 (m, 8H), 1.40 (s, 9H), 2.12 (d, 4H, J=14.4 Hz), 2.56 (t, 2H, J=7.8 Hz), 3.28-3.40 (m, 1H), 3.90 (s, 1H), 4.60-4.73 (m, 1H), 6.57 (s, 1H), 7.10 (d, 2H, J=8.4 Hz), 7.25 (d, 2H, J=8.4 Hz). 
     I-30 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.26-1.39 (m, 2H), 1.51-1.64 (m, 4H), 1.72-1.81 (m, 2H), 2.34 (t, 2H, J=6.9 Hz), 2.56 (t, 2H, J=7.8 Hz), 2.95-3.01 (m, 2H), 4.84 (t, 1H, J=5.7 Hz), 6.99-7.12 (m, 6H), 7.19-7.24 (m, 1H), 7.30 (s, 1H), 7.38-7.43 (m, 4H), 7.79 (d, 2H, J=8.7 Hz). 
     I-31 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.5 Hz), 1.21 (s, 9H), 1.28-1.62 (m, 8H), 2.07-2.14 (m, 4H), 2.64 (t, 2H, J=7.8 Hz), 3.11 (d, 1H, J=5.1 Hz), 3.20 (brs, 1H), 3.90-4.04 (m, 1H), 6.06-6.14 (m, 1H), 7.21 (t, 2H, J=8.1 Hz), 7.67 (t, 2H, J=8.4 Hz). 
     I-32 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.2 Hz), 1.27-1.65 (m, 8H), 1.40 (s, 9H), 2.10-2.23 (m, 4H), 2.65 (t, 2H, J=7.5 Hz), 3.23-3.35 (m, 1H), 3.49 (s, 1H), 3.88-4.02 (m, 1H), 5.84-5.92 (m, 1H), 7.13 (t, 2H, J=8.4 Hz), 7.65 (d, 2H, J=8.1 Hz). 
     I-33 
       1 H-NMR (CDCl 3 ) δ ppm: 0.94 (t, 3H, J=7.2 Hz), 1.30-1.42 (m, 2H), 1.32 (s, 9H), 1.57-1.66 (m, 2H), 2.67 (t, 2H, J=7.8 Hz), 5.61 (s, 1H), 6.93 (d, 2H, J=8.7 Hz), 7.25 (d, 2H, J=8.4 Hz), 7.49 (d, 2H, J=9.0 Hz), 7.80 (d, 2H, J=8.1 Hz), 8.22 (s, 1H). 
     I-34 
       1 H-NMR (CD 3 OD) δ ppm: 0.95 (t, 3H, J=7.5 Hz), 1.35 (s, 9H), 1.35-1.44 (m, 2H), 1.57-1.69 (m, 2H), 2.69 (t, 2H, J=7.5 Hz), 7.28-7.33 (m, 4H), 7.56 (d, 2H, J=9.0 Hz), 7.83 (d, 2H, J=8.4 Hz). 
     I-36 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.5 Hz), 1.31-1.70 (m, 11H), 1.39 (s, 9H), 1.75-1.85 (m, 1H), 2.65 (t, 2H, J=8.1 Hz), 3.13 (t, 2H, J=6.6 Hz), 3.40 (t, 2H, J=7.2 Hz), 4.10 (t, 1H, J=5.7 Hz), 6.21 (t, 1H, J=5.7 Hz), 7.23 (d, 2H, J=8.1 Hz), 7.67 (d, 2H, J=8.4 Hz). 
     I-37 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.5 Hz), 0.95-1.10 (m, 2H), 1.31-1.40 (m, 2H), 1.39 (s, 9H), 1.55-1.63 (m, 4H), 1.80-1.92 (m, 4H), 2.65 (t, 2H, J=7.8 Hz), 3.03 (t, 2H, J=6.6 Hz), 3.31 (t, 2H, J=6.6 Hz), 4.06 (t, 1H, J=6.0 Hz), 6.22 (t, 1H, J=6.0 Hz), 7.23 (d, 2H, J=8.4 Hz), 7.67 (d, 2H, J=8.1 Hz). 
     I-39 
       1 H-NMR (CDCl 3 ) δ ppm: 1.13 (t, 3H, J=7.2 Hz), 1.39 (s, 9H), 1.69-1.97 (m, 8H), 2.27-2.38 (m, 1H), 3.29-3.35 (m, 4H), 3.60-3.70 (m, 1H), 4.52 (d, 1H, J=9.3 Hz), 6.64 (d, 2H, J=8.4 Hz), 7.22 (s, 1H), 7.31 (d, 2H, J=9.0 Hz). 
     I-40 
       1 H-NMR (CDCl 3 ) δ ppm: 1.38 (s, 9H), 1.68-1.96 (m, 8H), 2.30-2.40 (m, 1H), 3.11 (t, 4H, J=4.8 Hz), 3.60-3.72 (m, 1H), 3.86 (t, 4H, J=4.8 Hz), 4.51 (brs, 1H), 6.89 (d, 2H, J=9.0 Hz), 7.42 (d, 2H, J=8.7 Hz). 
     I-41 
     mp: &gt;278° C. (dec.) 
       1 H-NMR (CDCl 3 ) δ ppm: 1.18-1.40 (m, 2H), 1.40 (s, 9H), 1.62-1.75 (m, 2H), 2.01-2.27 (m, 5H), 3.10-3.13 (m, 4H), 3.22-3.38 (m, 1H), 3.72 (d, 1H, J=9.3 Hz), 3.85-3.88 (m, 4H), 6.87 (d, 2H, J=9.0 Hz), 7.10 (s, 1H), 7.40 (d, 2H, J=9.0 Hz). 
     I-42 
       1 H-NMR (CDCl 3 ) δ ppm: 1.40 (s, 9H), 1.61-1.97 (m, 8H), 2.16 (s, 3H), 2.33-2.43 (m, 1H), 3.60-3.70 (m, 1H), 4.66 (brs, 1H), 7.12 (d, 1H, J=8.7 Hz), 7.46-7.50 (m, 1H), 7.62 (s, H), 7.75-7.78 (m, 1H), 7.86-7.91 (m, 2H). 
     I-43 
       1 H-NMR (CDCl 3 ) δ ppm: 1.40 (s, 9H), 1.62-2.00 (m, 8H), 1.87 (s, 3H), 2.36-2.47 (m, 1H), 3.24 (s, 3H), 3.64-3.74 (m, 1H), 4.87 (brs, 1H), 7.13 (d, 2H, J=9.0 Hz), 7.64 (d, 2H, J=8.4 Hz), 7.81 (s, H). 
     I-44 
     mp: 235-236° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.13 (t, 6H, J=6.9 Hz), 1.18-1.33 (m, 2H), 1.40 (s, 9H), 1.60-1.77 (m, 2H), 2.00-2.26 (m, 5H), 3.28-3.35 (m, 4H), 3.73 (d, 1H, J=9.3 Hz), 6.60-6.70 (m, 2H), 7.03 (brs, 1H), 7.31 (d, 2H, J=7.8 Hz). 
     I-45 
     mp: &gt;268° C. (dec.) 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.34 (m, 2H), 1.40 (s, 9H), 1.56-1.76 (m, 8H), 2.00-2.26 (m, 5H), 3.06-3.14 (m, 4H), 3.24-3.36 (m, 1H), 3.72 (d, 1H, J=9.3 Hz), 6.90 (d, 2H, J=8.7 Hz), 7.09 (s, 1H), 7.36 (d, 2H, J=8.7 Hz). 
     I-46 
     mp: &gt;272° C. (dec.) 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.28 (s, 9H), 1.31-1.59 (m, 7H), 1.87-2.00 (m, 4H), 2.23-2.34 (m, 1H), 3.00-3.16 (m, 1H), 4.35-4.45 (m, 2H), 6.81 (d, 1H, J=9.0 Hz), 7.16 (t, 1H, J=7.2 Hz), 7.43 (t, 1H, J=8.4 Hz), 7.52-7.58 (m, 3H), 8.04 (d, 1H, J=7.8 Hz), 8.43 (s, 1H). 
     I-47 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.36 (m, 2H), 1.40 (s, 9H), 1.62-1.77 (m, 2H), 1.98-2.32 (m, 5H), 3.31-3.40 (m, 1H), 3.62 (d, 1H, J=9.0 Hz), 7.08 (s, 1H), 7.29 (d, 2H, J=9.0 Hz), 7.61 (d, 2H, J=9.0 Hz). 
     I-48 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22-1.36 (m, 2H), 1.40 (s, 5H), 1.62-1.77 (m, 2H), 2.00-2.31 (m, 5H), 3.24-3.40 (m, 1H), 3.62 (d, 1H, J=10.2 Hz), 7.01 (t, 2H, J=8.7 Hz), 7.09 (s, 1H), 7.42-7.50 (m, 2H). 
     I-49 
     mp: 270° C. (dec.) 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.36 (m, 2H), 1.40 (s, 9H), 1.61-1.77 (m, 2H), 1.95-2.30 (m, 9H), 3.17-3.38 (m, 5H), 3.67 (d, 1H, J=9.8 Hz), 6.50 (d, 2H, J=9.0 Hz), 6.97 (s, 1H), 7.30 (d, 2H, J=9.0 Hz). 
     I-50 
     mp: 252-253° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.21-1.37 (m, 2H), 1.40 (s, 9H), 1.62-1.78 (m, 2H), 1.98-2.32 (m, 5H), 3.26-3.40 (m, 1H), 3.68 (d, 1H, J=9.6 Hz), 6.94-7.02 (m, 4H), 7.08 (t, 1H, J=7.5 Hz), 7.13 (s, 1H), 7.31 (t, 2H, J=7.5 Hz), 7.46 (d, 2H, J=9.0 Hz). 
     I-51 
     mp: 278-279° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.02 (d, 6H, J=6.9 Hz), 1.35 (s, 9H), 1.39-1.71 (m, 6H), 1.90-2.09 (m, 2H), 3.16-3.30 (m, 1H), 3.46 (d, 1H, J=9.0 Hz), 4.92-5.01 (m, 1H), 6.91-6.95 (m 2H), 7.00-7.07 (m, 3H), 7.13-7.16 (m, 2H), 7.30-7.36 (m, 2H). 
     I-52 
     mp: 276-277° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.36 (m, 2H), 1.40 (s, 9H), 1.60-1.78 (m, 2H), 1.98-2.30 (m, 5H), 2.36 (s, 3H), 2.58 (t, 4H, J=4.5 Hz), 3.17 (t, 4H, J=4.5 Hz),3.21-3.40(m, 1H), 3.64 (d, 1H, J=9.0 Hz), 6.88 (d, 2H, J=9.0 Hz), 7.01 (s, 1H), 7.37 (d, 2H, J=9.0 Hz). 
     I-53 
     mp: &gt;300° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.20-1.54 (m, 4H), 1.27 (s, 9H), 1.73-1.88 (m, 2H), 1.89-2.01 (m, 2H), 2.13-2.25 (m, 1H), 2.98-3.12 (m, 1H), 3.15-3.31 (m, 8H), 6.76-6.84 (m, 2H), 6.93 (d, 2H, J=9.0 Hz), 6.99 (d, 2H, J=8.1 Hz), 7.24 (d, 2H, J=8.1 Hz), 7.46 (d, 2H, J=9.0 Hz), 9.60 (s, 1H). 
     I-54 
     mp: &gt;215° C. (dec.) 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.27-2.00 (m, 18H), 2.14-2.26 (m, 1H), 2.53-2.84 (m, 4H), 2.86-3.30 (m, 2H), 3.46-3.54 (m, 1H), 3.62-3.74 (m, 2H), 6.78 (d, 1H, J=8.7 Hz), 6.87 (d, 2H, J=7.8 Hz), 7.42 (d, 2H, J=8.7 Hz), 9.58 (s, 1H). 
     I-55 
     mp: &gt;290° C. (dec.) 
       1 H-NMR (CDCl 3 ) δ ppm: 1.23-1.40 (m, 2H), 1.40 (s, 9H), 1.60-1.76 (m, 2H), 2.02-2.27 (m, 5H), 3.20 (t, 4H, J=5.4 Hz), 3.21-3.32 (m, 1H), 3.67 (d, 1H, J=9.3 Hz), 3.98 (t, 4H, J=4.8 Hz), 6.52 (t, 1H, J=4.8 Hz), 6.93 (d, 2H, J=8.4 Hz), 7.06 (s, 1H), 7.41 (d, 2H, J=8.7 Hz), 8.33 (d, 2H, J=4.8 Hz). 
     I-56 
     mp: &gt;232° C. (dec.) 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.27-1.48 (m, 4H), 1.80-1.99 (m, 4H), 2.14-2.25 (m, 1H), 3.04-3.24 (m, 8H), 3.68 (s, 3H), 3.76 (s, 3H), 6.44-6.47 (m, 1H), 6.66 (s, 1H), 6.76-6.84 (m, 2H), 6.92 (d, 2H, J=8.4 Hz), 7.46 (d, 2H, J=8.4 Hz), 9.61 (s, 1H). 
     I-57 
     mp: 284-285° C. (dec.) 
       1 H-NMR (CDCl 3 ) δ ppm: 1.27 (t, 3H, J=7.2 Hz), 1.40 (s, 9H), 1.61-2.24 (m, 9H), 2.35-2.49 (m, 1H), 2.76 (t, 2H, J=10.2 Hz), 3.04-3.15 (m, 2H), 3.20-3.36 (m, 1H), 3.55-3.59 (m, 2H), 3.87 (d, 1H, J=9.6 Hz), 4.12-4.19 (m, 2H), 6.90 (d, 2H, J=8.7 Hz), 2.79 (s, 1H), 7.40 (d, 2H, J=8.7 Hz). 
     I-58 
     mp: &gt;299° C. (dec.) 
       1 H-NMR (CDCl 3 ) δ ppm: 1.26-1.33 (m, 2H), 1.40 (s, 9H), 1.56-2.42 (m, 19H), 2.73-2.81 (m, 4H), 3.16-3.26 (m, 4H), 3.64 (d, 1H, J=9.6 Hz), 6.87 (d, 2H, J=8.7 Hz), 7.04 (s, 1H), 7.37 (d, 2H, J=9.0 Hz). 
     I-59 
     mp: &gt;270° C. (dec.) 
       1 H-NMR (CDCl 3 ) δ ppm: 1.26-1.47 (m, 2H), 1.47 (s, 9H), 1.60-1.80 (m, 4H), 2.01-2.32 (m, 5H), 3.28-3.40 (m, 3H), 3.62-3.74 (m, 3H), 5.74-5.96 (m, 2H), 6.92 (d, 2H, J=8.7 Hz), 7.13 (s, 1H), 7.39 (d, 2H, J=9.0 Hz). 
     I-60 
     mp: 247-250° C. (dec.) 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.37 (m, 2H), 1.40 (s, 9H), 1.60-1.78 (m, 2H), 1.98-2.33 (m, 5H), 2.93-3.03 (m, 2H), 3.22-3.40 (m, 1H), 3.52 (t, 2H, J=6.0 Hz), 3.62 (d, 1H, J=8.4 Hz), 4.36 (s, 2H), 6.93 (d, 2H, J=8.7 Hz), 7.00 (s, 1H), 7.11-7.22 (m, 4H), 7.39 (d, 2H, J=8.7 Hz). 
     I-61 
     mp: 260-281° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.21-1.38 (m, 2H), 1.41 (s, 9H), 1.64-1.80 (m, 2H), 2.02-2.33 (m, 5H), 3.24-3.40 (m, 1H), 3.61 (d, 1H, J=9.0 Hz), 6.33 (t, 2H, J=2.1 Hz), 7.04 (t, 2H, J=2.1 Hz), 7.14 (s, 1H), 7.34 (d, 2H, J=9.0 Hz), 7.56 (d, 2H, J=9.0 Hz). 
     I-62 
     mp: 260-262° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22-1.39 (m, 2H), 1.41 (s, 9H), 1.64-1.82 (m, 2H), 2.02-2.35 (m, 5H), 3.24-3.40 (m, 1H), 3.62 (d, 1H, J=9.6 Hz), 7.31 (d, 2H, J=9.0 Hz), 7.51 (s, 1H), 7.69 (d, 2H, J=9.0 Hz). 
     I-63 
     mp: 248° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.38 (m, 2H), 1.40 (s, 9H), 1.61-1.78 (m, 2H), 1.98-2.32 (m, 5H), 3.22-3.45 (m, 1H), 3.64 (d, 1H, J=9.3 Hz), 7.11 (s, 1H), 7.37-7.46 (m, 4H). 
     I-64 
     mp: 272-275° C. (dec.) 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.20-1.53 (m, 4H), 1.27 (s, 9H), 1.75-1.88 (m, 2H), 1.88-2.00 (m, 2H), 2.11-2.24 (m, 1H), 2.96-3.12 (m, 1H), 5.96 (s, 2H), 6.77 (d, 1H, J=8.7 Hz), 6.82 (d, 1H, J=8.4 Hz), 6.95 (dd, 1H, J=1.8, 8.4 Hz), 7.29 (d, 1H, J=1.8 Hz), 9.70 (s, 1H), 
     I-65 
     mp: 293-296° C. (dec.) 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.20-1.70 (m, 10H), 1.27 (s, 1.79-2.038 (m, 4H), 2.18-2.33 (m, 1H), 2.98-3.30 (m, 5H), 6.79 (d, 1H, J=9.0 Hz), 6.97 (d, 2H, J=8.1 Hz), 7.43-7.57 (m, 4H), 7.62 (d, 2H, J=8.1 Hz), 9.82 (s, 1H). 
     I-66 
     mp: &gt;300° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.27-1.53 (m, 4H), 1.86-1.99 (m, 4H), 2.22-2.34 (m, 1H), 2.39 (s, 3H), 3.00-3.14 (m, 1H), 6.25 (s, 1H), 6.79 (d, 1H, J=9.0 Hz), 7.47-7.50 (m, 1H), 7.69-7.76 (m, 1H), 10.27 (s, 1H). 
     I-67 
     mp: 248-249° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.20-1.54 (m, 4H), 1.27 (s, 9H), 1.77-1.90 (m, 2H), 1.90-2.02 (m, 2H), 2.02 (s, 3H), 2.17-2.32 (m, 1H), 2.96-3.13 (m, 1H), 6.78 (d, 1H, J=8.7 Hz), 7.12-7.30 (m, 3H), 7.89 (s, 1H), 9.79 (s, 1H), 9.88 (s, 1H). 
     I-68 
     mp: &gt;300° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.20-1.54 (m, 4H), 1.27 (s, 9H), 1.77-1.89 (m, 2H), 1.89-2.03 (m, 2H), 2.00 (s, 3H), 2.14-2.28 (m, 1H), 2.95-3.13 (m, 1H), 6.78 (d, 1H, J=8.7 Hz), 7.40-7.54 (m, 4H), 9.72 (s, 1H), 9.83 (s, 1H). 
     I-69 
     mp: 199-201° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.21-1.53 (m, 4H), 1.27 (s, 9H), 1.76-1.89 (m, 2H), 1.89-2.02 (m, 2H), 2.13-2.30 (m, 1H), 2.85 (s, 6H), 2.94-3.14 (m, 1H), 6.40 (dd, 1H, J=2.4, 8.4 Hz), 6.78 (d, 1H, J=8.7 Hz), 6.90 (d, 1H, J=8.4 Hz), 7.05 (t, 2H, J=8.4 Hz), 9.60 (s, 1H). 
     I-70 
     mp: 227-230° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.22-1.52 (m, 4H), 1.27 (s, 9H), 1.72-1.87 (m, 2H), 1.87-2.01 (m, 2H), 2.12-2.29 (m, 1H), 2.96-3.12 (m, 1H), 5.00 (s, 2H), 6.22 (d, 1H, J=7.5 Hz), 6.66 (d, 1H, J=7.5 Hz), 6.78 (d, 1H, J=9.0 Hz), 6.86 (d, 1H, J=7.5 Hz), 6.89-6.95 (m, 1H), 9.46 (s, 1H). 
     I-71 
     mp: 270-272° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.22-1.52 (m, 4H), 1.26 (s, 9H), 1.73-1.86 (m, 2H), 1.88-2.00 (m, 2H), 2.08-2.22 (m, 1H), 2.95-3.11 (m, 1H), 4.80 (s, 2H), 6.47 (d, 2H, J=8.4 Hz), 6.77 (d, 1H, J=8.4 Hz), 7.20 (d, 2H, J=8.4 Hz), 9.35 (s, 1H). 
     I-72 
     mp: 262-263° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.25 (d, 6H, J=6.3 Hz), 1.17-1.42 (m, 2H), 1.40 (s, 9H), 1.60-1.78 (m, 2H), 1.98-2.43 (m, 7H), 3.20-3.43 (m, 3H), 3.67 (d, 1H, J=9.6 Hz), 3.74-3.86 (m, 2H), 6.86 (d, 2H, J=9.0 Hz), 7.04 (s, 1H), 7.38 (d, 2H, J=9.0 Hz). 
     I-73 
     mp: 218-219° C. 
       1 H-NMR (CD 3 OD) δ ppm: 1.36 (s, 9H), 1.36-1.69 (m, 4H), 1.45 (s, 9H), 1.88-2.02 (m, 3H), 2.06-2.30 (m, 4H), 3.05-3.44 (m, 3H), 3.46-3.56 (m, 1H), 4.16-4.26 (m, 1H), 6.51 (d, 2H, J=9.0 Hz), 7.30 (d, 2H, J=8.7 Hz). 
     I-74 
     mp: 295-296° C. (dec.) 
       1 H-NMR (CD 3 OD) δ ppm: 1.36 (s, 9H), 1.36-1.67 (m, 4H), 1.92-2.13 (m, 4H), 2.26-2.40 (m, 2H), 2.62-2.75 (m, 1H), 3.16-3.25 (m, 1H), 3.58-3.98 (m, 4H), 4.16-4.25 (m, 1H), 7.20-7.30 (m, 2H), 7.62 (d, 2H, J=9.0 Hz). 
     I-75 
     mp 250-251° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.23-1.55 (m, 4H), 1.27 (s, 9H), 1.78-1.90 (m, 2H), 1.90-2.02 (m, 2H), 2.15-2.28 (m, 1H), 2.98-3.14 (m, 1H), 3.06 (t, 2H, J=8.4 Hz), 3.87 (t, 2H, J=8.4 Hz), 6.67 (dd, 1H, J=1.5, 7.2 Hz), 6.80 (d, 1H, J=8.4 Hz), 6.94-7.05 (m, 2H), 7.12-7.19 (m, 1H), 7.16 (d, 2H, J=9.3 Hz), 7.57 (d, 2H, J=9.3 Hz), 9.73 (s, 1H). 
     I-76 
     mp: 265-266° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.23-1.58 (m, 4H), 1.28 (s, 9H), 1.83-2.04 (m, 4H), 2.20-2.36 (m, 1H), 2.97-3.16 (m, 1H), 6.67 (d, 1H, J=3.0 Hz), 6.82 (d, 1H, J=8.4 Hz), 7.07-7.22 (m, 2H), 7.47-7.53 (m, 1H), 7.50 (d, 2H, J=9.0 Hz), 7.58 (d, 1H, J=3.0 Hz), 7.64 (d, 1H, J=7.5 Hz), 7.79 (d, 2H, J=9.0 Hz), 10.02 (s, 1H). 
     I-77 
     mp: 281° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.21-1.56 (m, 4H), 1.27 (s, 9H), 1.80-2.03 (m, 4H), 2.18-2.31(m, 1H), 2.97-3.14 (m, 1H), 6.51 (dd, 1H, J=2.1, 2.7 Hz), 6.81 (d, 1H, J=9.0 Hz), 7.67-7.78 (m, 6H), 8.41 (d, 1H, J=2.1 Hz), 9.96 (s, 1H). 
     I-78 
     mp: &gt;300° C. (dec.) 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.27-1.52 (m, 4H), 1.74-2.04 (m, 7H), 2.10-2.25 (m, 2H), 2.96-3.20 (m, 2H), 3.48-3.53 (m, 1H), 3.75-3.84 (m, 1H), 6.39 (d, 2H, J=8.4 Hz), 6.79 (d, 1H, J=8.4 Hz), 7.02 (s, 1H), 7.30 (s, 1H), 7.36 (d, 2H, J=8.1 Hz), 9.48 (s, 1H). 
     I-79 
     mp: 243-250° C. (dec.) 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.27-1.54 (m, 4H), 1.85-1.99 (m, 4H), 2.24-2.33 (m, 1H), 3.00-3.14 (m, 1H), 6.82 (d, 1H, J=8.7 Hz), 7.77 (d, 2H, J=8.4 Hz), 8.07 (d, 2H, J =8.4 Hz). 
     I-80 
     mp: &gt;300° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.22-1.58 (m, 4H), 1.27 (s, 9H), 1.80-2.03 (m, 4H), 2.18-2.32 (m, 1H), 2.98-3.14 (m, 1H), 6.80 (d, 1H, J=8.7 Hz), 7.35-7.50 (m, 2H), 7.99 (s, 1H), 8.11 (s, 1H), 9.79 (s, 1H), 12.94 (s, 1H). 
     I-81 
     mp: 261-262° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.21-1.57 (m, 4H), 1.27 (s, 9H), 1.78-2.02 (m, 4H), 2.17-2.30 (m, 1H), 2.96-3.16 (m, 1H), 6.34 (s, 1H), 6.80 (d, 1H, J=8.7 Hz), 7.14-7.32 (m, 3H), 7.85 (s, 1H), 9.58 (s, 1H), 10.95 (s, 1H). 
     I-82 
       1 H-NMR (CDCl 3 ) δ ppm: 0.86 (s, 18H), 1.24-1.37 (m, 2H), 1.37 (s, 9H), 1.56-1.74 (m, 2H), 1.95-2.19 (m, 5H), 3.18-3.32 (m, 1H), 3.44 (t, 4H, J=6.3 Hz), 3.70 (t, 4H, J=6.3 Hz), 4.39 (d, 1H, J=9.0 Hz), 6.59 (d, 2H, J=9.0 Hz), 7.31 (d, 2H, J=8.7 Hz), 7.43 (s, 1H), 
     I-83 
     mp: 264-265° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.27-2.52 (m, 4H), 1.78-1.88 (m, 2H), 1.90-2.00 (m, 2H), 2.14-2.26 (m, 1H), 2.96-3.14 (m, 1H), 6.72-6.82 (m, 2H), 6.99 (t, 4H, J=7.8 Hz), 7.18 (t, 2H, J=7.5 Hz), 7.46 (d, 2H, J=9.0 Hz), 8.00 (s, 1H), 9.65 (s, 1H). 
     I-84 
     mp: 257° C. (dec.) 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.23-1.57 (m, 4H), 1.27 (s, 9H), 1.83-2.03 (m, 4H), 2.23-2.35 (m, 1H), 2.98-3.15 (m, 1H), 6.80 (d, 1H, J=8.1 Hz), 7.87 (d, 2H, J=9.0 Hz), 8.34 (d, 2H, J=9.0 Hz), 9.21 (s, 1H), 10.20 (s, 1H). 
     I-85 
     mp: 256-258° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.22-1.53 (m, 4H), 1.26 (s, 9H), 1.79-2.01 (m, 4H), 2.25 (s, 3H), 2.28-2.42 (m, 1H), 2.97-3.02 (m, 1H), 6.71 (d, 1H, J=0.9 Hz), 6.80 (d, 1H, J=8.1 Hz), 11.91 (s, 1H). 
     I-86 
     mp: 228-230° C. 
       1 H-NMR (CD 3 OD) δ ppm: 1.36 (s, 9H), 1.36-1.48 (m, 2H), 1.55-1.70 (m, 2H), 1.87-1.98 (m, 2H), 2.08-2.17 (m, 2H), 2.20-2.32 (m, 1H), 3.15-3.27 (m, 1H), 3.50 (t, 4H, J=5.7 Hz), 3.69 (t, 4H, J=5.7 Hz), 6.72 (d, 2H, J=9.0 Hz), 7.29-7.33 (m, 2H). 
     I-87 
     mp: 183-184° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.27-1.48 (m, 4H), 1.73-1.89 (m, 4H), 1.90-2.00 (m, 2H), 2.16-2.28 (m, 1H), 2.28 (t, 2H, J=7.5 Hz), 2.51-2.54 (m, 2H), 2.97-3.13 (m, 1H), 3.58 (s, 3H), 6.79 (d, 1H, J=8.7 Hz), 7.08 (d, 2H, J=8.7 Hz), 7.49 (d, 2H, J=8.4 Hz), 9.73 (s, 1H). 
     I-88 
     mp: 217-218° C. 
       1 H-NMR (CD 3 OD) δ ppm: 1.36 (s, 9H), 1.36-1.46 (m, 2H), 1.55-1.69 (m, 2H), 1.83-2.00 (m, 4H), 2.07-2.18 (m, 2H), 2.26-2.36 (m, 3H), 2.61 (t, 2H, J=7.5 Hz), 3.14-3.26 (m, 1H), 7.13 (d, 2H, J=8.1 Hz), 7.44 (d, 2H, J=8.1 Hz). 
     I-89 
       1 H-NMR (CDCl 3 ) δ ppm: 0.08 (d, 6H, J=3.3 Hz), 0.88 (s, 9H), 1.21-1.36 (m, 2H), 1.39 (s, 9H), 1.61-1.74 (m, 2H), 1.88-2.23 (m, 6H), 3.06-3.11 (m, 1H), 3.24-3.74 (m, 4H), 3.92 (d, 1H, J=9.6 Hz), 4.48-4.56 (m, 1H), 6.47 (d, 2H, J=9.0 Hz), 7.17 (s, 1H), 7.32 (d, 2H, J=9.0 Hz). 
     I-90 
     mp: amorphous 
       1 H-NMR (CD 3 OD) δ ppm: 1.36 (s, 9H), 1.36-1.47 (m, 2H), 1.56-1.70 (m, 3H), 1.88-2.30 (m, 6H), 3.05-3.49 (m, 5H), 4.50 (brs, 1H), 6.50 (d, 2H, J=9.0 Hz), 7.29 (d, 2H, J=9.0 Hz). 
     I-91 
     mp: 105-106° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.3 Hz), 1.25-1.27 (m, 2H), 1.36 (d, 6H, J=6.9 Hz), 1.51-1.59 (m, 2H), 2.56 (t, 2H, J=7.8 Hz), 3.27 (sept, 1H, J=6.9 Hz), 7.12 (d, 2H, J=8.6 Hz), 7.32 (t, 1H, J=7.8 Hz), 7.45 (brd, 1H, J=7.8 Hz), 7.53 (d, 2H, J=8.6 Hz), 7.58 (d, 1H, J=7.8 Hz), 7.71-7.72 (m, 2H), 8.27 (s, 1H). 
     I-92 
     mp: 163-164° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 1.32-1.39 (m, 2H), 1.55-1.65 (m, 2H), 1.87 (s, 3H), 1.95 (s, 3H), 2.60 (t, 2H, J=7.6 Hz), 7.07 (d, 2H, J=8.4 Hz), 7.18 (d, 2H, J=8.5 Hz), 7.54 (d, 2H, J=8.5 Hz), 7.91 (brs, 1H), 8.18 (d, 2H, J=8.4 Hz), 8.77 (s, 1H). 
     I-93 
     mp: 173° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 1.32-1.40 (m, 2H), 1.39 (d, 61-1, J=6.9 Hz), 1.55-1.62 (m, 2H), 2.60 (t, 2H, J=7.8 Hz), 3.13 (sept, 1H, J=6.9 Hz), 4.39 (d, 2H, J=6.3 Hz), 4.45 (t, 1H, J=6.3 Hz), 7.18 (d, 2H, J=8.7 Hz), 7.46 (d, 2H, J=8.7 Hz), 7.54 (d, 2H, J=8.7 Hz), 7.80 (s, 1H), 7.85 (d, 2H, J=8.7 Hz). 
     I-94 
     mp: 159-160° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 1.32-1.39 (m, 2H), 1.54-1.80 (m, 2H), 1.79 (s, 3H), 1.80 (s, 3H), 2.60t, 2H, J=7.7 Hz), 3.18 (s, 3H), 7.18 (d, 2H, J=8.5 Hz), 7.30 (d, 2H, J=8.8 Hz), 7.52 (d, 2H, J=8.5 Hz), 7.70 (brs, 1H), 7.84 (d, 2H, J=8.8 Hz), 8.77 (s, 1H). 
     I-95 
     mp: 177-178° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.94 (t, 3H, J=7.2 Hz), 1.31-1.48 (m, 8H), 1, 54-1.66 (m, 2H), 2.55 (s, 3H), 2.62 (t, 2H, J=7.6 Hz), 3.92 (sept, 1H, J=6.6 Hz), 7.20 (d, 2H, J=8.45 Hz), 7.74 (d, 2H, J=8.5 Hz), 9.01 (brs, 1H), 9.17 (s, 1H). 
     I-96 
     mp: 220-223° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 1.28-1.42 (m, 2H), 1.50 (d, 6H, J=6.8 Hz), 1.54-1.65 (m, 2H), 2.62 (t, 2H, J=7.6 Hz), 4.08 (sept, 11-1, J=7.1 Hz), 7.20 (d, 2H, J=8.5 Hz), 7.48 (d, 2H, J=8.5 Hz), 7.71 (brs, 1H), 8.51 (brs, 1H), 8.95 (s, 1H). 
     I-97 
     mp: 195-197° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.6 Hz), 0.94 (t, 3H, J=7.3 Hz), 1.32-1.44 (m, 6H), 1.54-1.64 (m, 2H), 1.66-1.78 (m, 2H), 2.62 (t, 2H, J=7.7 Hz), 2.86 (brs, 2H), 3.98 (sept, 1H, J=7.1 Hz), 7.19 (d, 2H, J=8.5 Hz), 7.63 (d, 2H, J=8.4 Hz), 8.72 (brs, 1H), 8.81 (brs, 1H). 
     I-98 
     mp: 216-218° C. 
       1 H-NMR (CDCl 3 +CD 3 OD) δ ppm: 0.93 (t, 3H, J=7.4 Hz), 1.29-1.40 (m, 2H), 1.43 (d, 2H, J =6.9 Hz), 1.51-1.63 (m, 2H), 2.60 (t, 2H, J=7.8 Hz), 3.65 (sept, 1H, J=6.9 Hz), 7.18 (d, 2H, J=8.5 Hz), 7.22 (d, 1H, J=8.8 Hz), 7.55 (d, 2H, J=8.5 Hz), 8.18 (dd, 1H, J=8.8, 2.4 Hz), 8.63 (d, 1H, J=2.4 Hz). 
     I-99 
     mp: 201-202° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 1.22-1.40 (m, 2H), 1.49 (d, 2H, J=7.1 Hz), 1.51-1.63(m 2H),2.59 (t, 2H, J=7.7Hz), 4.22 (sept, 1H, J=7.1 Hz), 7.16 (d, 2H, J=8.4 Hz), 7.41 (brs, 1H), 7.52 (d, 2H, J=8.4 Hz), 8.10 (brs, 1H), 8.13 (d, 1H, J=2.2 Hz), 8.61 (brs, 1H). 
     I-100 
     mp: 160-162° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 1.22-1.42 (m, 2H), 1.45 (d, 2H, J=6.9 Hz), 1.51-1.63 (m, 2H), 2.61 (t, 2H, J=7.8 Hz), 3.37 (sept, 1H, J=6.9 Hz), 6.89 (brs, 1H), 7.19 (d, 2H, J=8.4 Hz), 7.65 (d, 2H, J=8.4 Hz), 7.80 (dd, 1H, J=8.4, 2.4 Hz), 8.27 (d, 1H, J=8.4 Hz), 8.45 (d, 1H, J=2.4 Hz), 9.75 (brs, 1H). 
     I-101, I-214 
     mp: 192-194° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 1.27-1.41 (m, 2H), 1.35 (s, 9H), 1.50-1.66 (m, 2H), 2.60 (t, 2H, J=7.6 Hz), 5.58 (brs, 1H), 7.07 (d, 2H, J=8.5 Hz), 7.17 (d, 2H, J =8.5 Hz), 7.52 (d, 2H, J=8.5 Hz), 7.71 (brs, 1H), 7.79 (d, 2H, J=8.5 Hz). 
     I-102 
     mp: 216-217° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 1.26-1.42 (m, 2H), 1.45 (s, 9H), 1.70-1.83 (m, 2H), 2.60 (t, 2H, J=7.7 Hz), 6.42 (brs, 1H), 7.18 (d, 2H, J=8.5 Hz), 7.35 (d, 2H, J =8.5 Hz), 7.51 (d, 2H, J=8.5 Hz), 7.68 (brs, 1H), 7.82 (d, 2H, J=8.5 Hz). 
     I-103 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.3 Hz), 1.28-1.36 (m, 2H), 1.32 (d, 6H, J=6.9 Hz), 1.49-1.59 (m, 2H), 2.54 (t, 2H, J=7.7 Hz), 3.23 (sept, 1H, J=6.9 Hz), 3.46 (s, 3H), 6.76 (brs, 1H), 6.91 (d, 2H, J=8.2 Hz), 6.99 (d, 2H, J=8.8 Hz), 7.03 (d, 2H, J=8.2 Hz), 7.25 (d, 2H, J=8.8 Hz). 
     I-104 
     mp: 182-183° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 1.28-1.40 (m, 2H); 1.51-1.63 (m, 2H), 1.64-1.88 (m, 4H), 1.90-2.23 (m, 4H), 2.60 (t, 2H, J=7.6 Hz), 3.39 (m, 1H), 6.16 (brs, 1H), 7.07 (d, 2H, J=8.5 Hz), 7.16 (d, 2H, J=8.5 Hz), 7.52 (d, 2H, J=8.5 Hz),7.74 (brs, 1H), 7.77 (d, 2H, J=8.5 Hz). 
     I-105 
     mp: 190-191° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 1.28-1.41 (m, 2H), 1.52-1.69 (m, 4H), 1.75-1.90 (m, 2H), 1.92-2.07 (m, 4H), 2.58 (t, 2H, J=7.6 Hz), 3.59 (m, 1H), 6.53 (brs, 1H), 7.18 (d, 2H, J=8.5 Hz), 7.31 (d, 2H, J=8.5 Hz), 7.52 (d, 2H, J=8.5 Hz), 7.67 (brs, 1H), 7.84 (d, 2H, J=8.5 Hz). 
     I-106 
     mp: 194-197° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 1.22-1.41 (m, 2H), 1.53-1.65 (m, 2H), 1.90 (s, 6H), 2.60 (t, 2H, J=7.8 Hz), 6.86 (brs, 1H), 7.18 (d, 2H, J=8.5 Hz), 7.43 (d, 2H, J=8.5 Hz), 7.51 (d, 2H, J=8.5 Hz), 7.71 (brs, 1H), 7.84 (d, 2H, J=8.5 Hz). 
     mp: 215-218° C. 
       1 H-NMR (CDCl 3 +CD 3 OD) δ ppm: 0.97 (t, 3H, J=7.4 Hz), 1.24-1.40 (m, 4H), 1.39 (s, 9H), 1.42-1.50 (m, 2H), 1.54-1.72 (m, 2H), 1.76-1.82 (m, 2H), 1.91-2.00 (m, 2H), 2.06-2.22 (m, 3H), 3.24 (7, 1H), 4.00 (t, 2H, J=6.6 Hz), 6.78 (d, 1H, J=8.8 Hz), 6.98 (dd, 1H, J=8.8, 2.5 Hz), 7.09 (d, 1H, J=8.8 Hz). 
     I-167 
     mp: 212-213° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.96 (t, 3H, J=7.5 Hz), 1.26-1.34 (m, 2H), 1.40 (s, 9H), 1.45-1.50 (m, 2H), 1, 68-1.77 (m, 4H), 2.03-2.08 (m, 2H), 2.17 (m, 1H), 2.26-2.29 (m, 2H), 3.29 (m, 1H), 3.60 (d, 3H, J=9.0 Hz), 4.25 (t, 2H, J=6.8 Hz), 6.71 (d, 1H, J=8.4 Hz), 7.01 (brs, 1H), 7.91 (dd, 1H, J=8.4, 3.3 Hz), 8.08 (d, 1H, J=3.3 Hz). 
     I-168 
     mp: 230-232° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22-1.35 (m, 2H), 1.40 (s, 9H), 1.63-1.77 (m, 2H), 2.03-2.08 (m, 2H), 2.15-2.29 (m, 3H), 3.31 (m, 1H), 3.63 (d, 1H, J=9.3 Hz), 6.89 (d, 1H, J=9.4 Hz), 7.10 (brd, 2H, J=7.4 Hz), 7.12 (brs, 1H), 7.18 (t, 1H, J=7.4 Hz), 7.36 (brt, 2H, J=7.4 Hz), 8.09-8.15 (m, 2H). 
     I-169 
     mp: 159-160° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.97 (t, 3H, J=7.3), 1.20-1.35 (m, 2H), 1.40 (s, 9H), 1.37-1.49 (m, 2H), 1.61-1.78 (m, 4H), 2.05-2.08 (m, 2H), 2.23-2.26 (m, 2H), 2.36 (s, 3H), 2.97 (brs, 1H), 3.32 (m, 1H), 3.86 (brs, 1H), 4.30 (t, 2H, J=6.5 Hz), 6.25 (s, 1H), 7.92 (brs, 1H). 
     I-170 
     mp: 180-181° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.88-0.89 (m, 2H), 1.39 (s, 9H), 1.42-1.60 (m, 2H) 1.86-1.90 (m, 2H), 2.04-2.09 (m, 2H) 2.42 (s, 3H), 2.91 (m, 1H), 3.20 (m, 1H), 3.63 (d, 1H, J=9.2Hz), 6.38 (s, 
     I-107 
     mp: 211-212° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 1.24-1.40 (m, 2H), 1.50-1.62 (m, 2H), 2.60 (t, 2H, J=7.6 Hz), 6.19 (brs, 1H), 7.17 (d, 2H, J=8.5 Hz), 7.18 (d, 2H, J=8.5 Hz), 7.51 (d, 2H, J=8.5 Hz), 7.66 (brs, 1H), 7.86 (d, 2H, J=8.5 Hz). 
     I-108 
     mp: 298-300° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 0.90 (t, 3H, J=7.3 Hz), 1.22-1.39 (m, 2H), 1.48-1.60 (m, 2H), 2.54 (t, 2H, J=7.3 Hz), 7.04 (d, 2H, J=8.8 Hz), 7.12 (d, 2H, J=8.5 Hz), 7.64 (d, 2H, J=8.5 Hz), 7.69 (d, 2H, J=8.8 Hz), 9.80 (s, 1H). 
     I-109 
     mp: 122-123° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.90 (t, 3H, J=7.4 Hz), 0.97 (t, 3H, J=7.7 Hz), 1.26-1.38 (m, 2H), 1.30 (s, 6H), 1.50-1.66 (m, 4H), 1.72-1.83 (m, 4H), 2.34 (t, 2H, J=7.1 Hz), 2.55 (t, 2H, J=7.6 Hz), 3.19 (q, 1H, J=6.0 Hz), 4.60 (brs, 1H) 7.08 (d, 2H, J=8.5 Hz), 7.42 (d, 2H, J=8.5 Hz), 7.85 (s, 1H). 
     I-110 
     mp: 109-110° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.4 Hz), 1.10 (d, 6H, J=6.7 Hz), 1.29-1.38 (m, 2H), 1.55 (s, 9H), 1.60-1.70 (m, 2H), 1.78-1.89 (m, 2H), 2.26 (m, 1H), 2.39 (t, 2H, J=7.0 Hz), 2.57 (t, 2H, J=7.7 Hz), 2.90 (d, 2H, J=6.6 Hz), 3.16 (brs, 1H), 4.24 (brs, 1H), 7.12 (d, 2H, J=8.5 Hz), 7.40 (d, 2H, J=8.5 Hz). 
     I-111 
     mp: 64-65° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.3 Hz), 1.02 (t, 3H, J=7.5 Hz), 1.35 (d, 3H, J=6.7 Hz), 1.26-1.38 (m, 2H), 1.48-1.69 (m, 5H), 1.76-1.87 (m, 2H), 2.04 (m, 1H), 2.38 (t, 2H, J=7.3 Hz), 2.56 (t, 2H, J=7.6 Hz), 2.91 (m, 1H), 3.16 (brs, 2H), 4.42 (brs, 1H), 7.11 (d, 2H, J=8.5 Hz), 7.42 (d, 2H, J=8.5 Hz), 7.47 (brs, 1H). 
     I-112 
     mp: 79-80° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.36 (s, 9H), 1.52-1.62 (m, 2H), 1.67-1.76 (m, 2H), 2.22 (t, 2H, J=7.4 Hz), 3.16 (q, 2H, J=6.3 Hz), 3.78 (s, 3H), 4.33 (d, 2H, J=5.4 Hz), 4.62 (brs, 1H), 6.20 (brs, 1H), 6.85 (d, 2H, J=8.8 Hz), 7.19 (d, 2H, J=8.8 Hz). 
     I-113 
     mp: 125-126° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.38 (s, 9H), 1.62-1.70 (m, 2H), 1.76-1.88 (m, 2H), 2.46 (t, 2H, J=7.4 Hz), 3.22 (q, 2H, J=6.1 Hz), 4.22 (t, 1H, J=6.1 Hz), 7.24 (dd, 1H, J=8.9, 2.3 Hz), 7.36 (d, 1H, J=2.3 Hz), 7.65 (brs, 1H), 8.29 (d, 1H, J=8.9 Hz). 
     I-114 
     mp: 89-91° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.0 Hz), 1.06 (d, 6H, J=7.0 Hz), 1.36 (m, 1H), 1.50-1.72 (m, 5H), 1.94-2.06 (m, 2H), 2.26 (m, 1H), 2.60 (t, 2H, J=7.7 Hz), 2.84 (t, 2H, J=7.7 Hz), 2.93 (d, 2H, J=6.3 Hz), 3.20 (t, 2H, J=6.6 Hz), 4.30 (brs, 1H), 7.19 (d, 2H, J=8.5 Hz), 7.63 (d, 2H, J=8.5 Hz), 9.15 (brs, 1H). 
     I-115 
     mp: 94-96° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.5 Hz), 1.03 (t, 3H, J=7.5 Hz), 1.23-1.40 (m, 5H), 1.42-1.65 (m, 6H), 1.75 (m, 1H), 2.02 (m, 1H), 2.24 (t, 2H, J=7.0 Hz), 2.59 (t, 2H, J=8.0 Hz), 2.90 (m, 1H), 3.14 (q, 2H, J=6.6 Hz), 4.20 (m, 1H), 4.40 (d, 2H, J=5.4 Hz), 5.70 (brs, 1H), 7.14 (d, 2H, J=8.1 Hz), 7.18 (d, 2H, J=8.1 Hz). 
     I-116 
     mp: 89-91° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.97 (t, 3H, J=7.3 Hz), 1.02 (t, 3H, J=7.5 Hz), 1.35 (d, 3H, J=7.0 Hz), 1.40-1.90 (m, 9H), 2.04 (m, 1H), 2.37 (t, 2H, J=7.0 Hz), 2.90 (m, 1H), 3.17 (q, 2H, J=6.6 Hz), 3.93 (t, 2H, J=6.6 Hz), 4.32 (m, 1H), 6.84 (d, 2H, J=9.0 Hz), 7.31 (brs, 1H), 7.40 (d, 2H, J=9.0 Hz). 
     I-117 
     mp: 110-111° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.02 (t, 3H, J=7.5 Hz), 1.34 (d, 3H, J=6.6 Hz), 1.45-1.70 (m, 3H), 1.75-1.85 (m, 2H), 2.05 (m, 1H), 2.36 (t, 2H, J=7.5 Hz), 2.90 (m, 1H), 3.16 (q, 2H, J=6.6 Hz), 3.78 (s, 3H), 4.50 (m, 1H), 6.84 (d, 2H, J=6.8 Hz), 7.42 (d, 2H, J=6.8 Hz), 7.48 (brs, 1H). 
     I-118 
     mp: 113-115° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.92 (t, 3H, J=7.0 Hz), 1.20-1.34 (m, 1H), 1.37 (d, 6H, J=7.0 Hz), 1.48-1.70 (m, 3H), 2.43 (q, 2H, J=6.6 Hz), 2.58 (t, 2H, J=7.7 Hz), 3.30-3.31 (m, 3H), 4.75 (m, 1H), 6.04 (d, 1H, J=15.0 Hz), 6.77 (dt, 1H, J=7.7, 15.0 Hz), 7.14 (d, 2H, J=8.4 Hz), 7.55 (d, 2H, J=8.4 Hz), 7.85 (brs, 1H). 
     I-119 
     mp: 139-140° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.19 (s, 9H), 1.47 (m, 2H), 1.61 (m, 2H), 2.18 (t, 2H, J=7.6 Hz), 3.03 (q, 2H, J=6.3 Hz), 4.09 (t, 1H, J=5.9 Hz), 6.85 (brd, 1H, J=8.0 Hz), 7.00 (t, 1H, J=8.0 Hz), 7.16 (brd, 1H, J=8.0), 7.48 (brs, 1H), 7.57 (brs, 1H). 
     I-120 
     mp: 183° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.3 Hz), 1.20-1.58 (m, 6H), 1.40 (s, 9H), 2.07 (dd, 1H, J=12.9, 3.1 Hz), 2.52 (t, 2H, J=7.7 Hz), 2.95 (dd, 2H, J=11.5, 2.5 Hz), 3.46 (m, 1H), 3.88-4.07 (m, 3H), 6.47 (s, 1H), 7.08 (d, 2H, J=8.5 Hz), 7.22 (d, 2H, J=8.5 Hz). 
     I-121 
     mp: 163-166° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.3 Hz), 1.32-1.62 (m, 6H), 1.45 (s, 9H), 1.95-2.07 (m, 3H), 2.20 (m, 1H), 2.46 (td, 1H, J=10.4, 3.7 Hz), 2.37 (t, 2H, J=7.6 Hz), 3.43 (brd, 2H, J=10.4 Hz), 4.80 (s, 1H), 7.12 (d, 2H, J=−8.4 Hz) 7.14 (s, 1H), 7.39 (d, 2H, J=8.4 Hz). 
     I-122 
     mp: 188-189° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.25-1.41 (m, 2H), 1.42 (s, 9H), 1.50-1.62 (m, 2H), 1.78-1.95 (m, 4H), 2.00-2.20 (m, 6H), 2.57 (t, 2H, J=7.5 Hz), 3.99 (brs, 1H), 7.10 (brs, 1H), 7.12 (d, 2H, J=6.51 Hz), 7.41 (d, 2H, J=6.51 Hz). 
     I-123 
     mp: 197-198° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.91 (t, 3H, J=7.5 Hz), 1.24-1.40 (m, 2H), 1.39 (s, 9H), 1.50-1.70 (m, 2H), 1.99 (brs, 12H), 2.56 (t, 2H, J=7.5 Hz), 3.47 (brs, 1H), 7.10 (s, 1H), 7.11 (d, 2H, J=8.5 Hz), 7.38 (d, 2H, J=8.5 Hz). 
     I-124 
     mp: 258-260° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.40 (m, 2H), 1.41 (s, 9H), 1.62-1.81 (m, 2H), 2.03-2.35 (m, 5H), 2.37 (s, 3H), 2.71 (s, 3H), 3.32 (m, 1H), 3.64 (d, 1H, J=8.4 Hz), 7.08 (brs, 1H), 7.24 (m, 1H), 7.33 (m, 2H), 7.60 (d, 1H, J=8.1 Hz), 7.77 (s, 1H), 7.80 (d, 1H, J=8.4 Hz), 8.14 (m, 1H). 
     I-125 
     mp: 297-299° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.28-1.56 (m, 4H), 1.80-2.01 (m, 4H), 2.47 (m, 1H), 2.76 (brs, 1H), 3.05 (m, 2H), 6.78 (d, 1H, J=9.0 Hz), 7.23 (d, 1H, J=9.0 Hz), 7.46 (dd, 1H, J=2.0, 9.0 Hz), 8.03 (d, 1H, J=2.0 Hz). 
     I-126 
     mp: 198-199° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 118-1.39 (m, 2H), 1.40 (s, 9H), 1.60-4.79 (m, 2H), 1.98-2.35 (m, 5H), 3.30 (m, 1H), 3.67 (d, 1H, J=9.6 Hz), 5.89 (tt, 1H, J=3.0, 50.0 Hz), 6.97 (d, 1H, J=7.8 Hz), 7.21 (s, 1H), 7.30-7.40 (m, 2H), 7.55 (s, 11-1) 
     I-127 
     mp: 262-264° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.39 (m, 2H), 1.41 (s, 9H), 1.60-1.80 (m, 2H), 2.00-2.36 (m, 5H), 2.57 (s, 3H), 3.33 (m, 1H), 3.62 (d, 1H, J=8.7 Hz), 7.28 (brs, 1H), 7.62 (d, 2H, J=8.7 Hz), 7.94 (d, 2H, J=8.7 Hz). 
     I-128 
     mp: 252-254° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.18-1.39 (m, 2H), 1.40 (s, 9H), 1.58-1.79 (m, 2H), 1.99-2.30 (m, 5H), 2.46 (s, 3H), 3.32 (m, 1H), 3.64 (m, 1H), 7.11 (brs, 1H), 7.23 (d, 2H, J=9.0 Hz), 7.44 (d, 2H, J=9.0 Hz). 
     I-129 
     mp: &gt;300° C. 
       1 H-NMR (CDCl 3 +CD 3 OD) δ ppm: 1.30-1.45 (m, 2H), 1.42 (s, 9H), 1.70-1.88 (m, 2H), 2.10-2.37 (m, 4H), 2.52 (m, 1H), 3.34 (m, 1H), 7.43-7.54 (m, 3H), 7.82 (d, 1H, J=6.7 Hz), 7.88 (d, 1H, J=8.5 Hz), 7.98-8.07 (m, 2H), 8.44 (s, 1H), 8.46 (s, 1H). 
     I-130 
     mp: 123-124° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.18-1.34 (m, 2H), 1.40 (s, 9H), 1.62-1.75 (m, 2H), 2.00-2.28 (m, 5H), 3.31 (m, 1H), 3.61 (d, 1H, J=9.5 Hz), 5.59 (s, 1H), 7.17 (s, 1H), 7.30-7.37 (m, 6H), 7.41 (d, 1H, J=8.5 Hz), 7.84 (d, 1H, J=2.1 Hz). 
     I-131 
     mp: 202-204° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.27-1.38 (m, 2H), 1.38 (s, 9H), 1.62-1.75 (m, 2H), 1.97-2.04 (m, 2H), 2.18-2.27 (m, 3H), 3.26 (m, 1H), 3.81 (s, 3H), 4.62 (d, 1H, J=7.9 Hz), 7.12 (d, 1H, J=7.8 Hz), 7.40 (t, 1H, J=7.8 Hz), 7.51 (s, 3H), 7.61 (d, 1H, J=7.8 Hz), 7.71 (s, 1H), 8.21 (brs, 1H). 
     I-132 
     mp: 236-237° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.23-1.43 (m, 2H), 1.41 (s, 9H), 1.66-1.80 (m, 2H), 2.08-2.12 (m, 2H), 2.23-2.31 (m, 3H), 3.34 (m, 1H), 3.87 (d, 1H, J=9.5 Hz), 4.02 (s, 3H), 7.30 (td, 1H, J=7.3, 1.1 Hz), 7.36 (s, 1H), 7.39 (td, 1H, J=7.3, 1.5 Hz), 7.53 (brd, 1H, J=7.3 Hz), 7.84 (brd, 1H, J=7.3 Hz), 8.05 (s, 1H), 8.73 (s, 1H). 
     I-133 
     mp: 198-200° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 0.97 (t, 3H, J=6.7 Hz), 1.18-1.81 (m, 7H), 1.39 (s, 9H), 1.98-2.05 (m, 2H), 2.21-2.24 (m, 3H), 3.29 (m, 1H), 4.00 (dd, 1H, J=10.7, 6.7 Hz), 4.09 (dd, 1H, J=10.7, 6.1 Hz), 4.27 (d, 1H, J=9.8 Hz), 6.37 (d, 1H, J=15.9 Hz), 7.47 (d, 2H, J=8.51 Hz), 7.59 (d, 2H, J=8.5 Hz), 7.62 (d, 1H, J=15.9 Hz), 7.83 (brs, 1H). 
     I-134 
     mp: 212-213° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.21-1.32 (m, 2H), 1.39 (s, 9H), 1.59-1.73 (m, 2H), 1.99-2.04 (m, 2H), 2.10-2.26 (m, 3H), 3.26 (m, 1H), 3.72 (d, 1H, J=9.6 Hz), 6.74 (m, 1H), 7.02 (d, 2H, J=7.4 Hz), 7.11 (t, 1H, J=7.4 Hz), 7.13-7.19 (m, 2H), 7.22-7.26 (m, 2H), 7.34 (t, 2H, J=7.4 Hz). 
     I-135 
     mp: 294-296° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.28-1.55 (m, 4H), 1.81-2.05 (m, 4H), 2.26 (m, 1H), 2.98-3.20 (m, 2H), 6.78 (d, J=9.0 Hz), 7.31 (t, 1H, J=7.5 Hz), 7.54-7.72 (m, 5H), 7.94 (brs, 1H). 
     I-136 
     mp: &gt;300° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.28 (s, 9H), 1.29-1.59 (m, 4H), 1.81-2.02 (m, 4H), 2.27 (m, 1H), 3.06 (m, 1H), 6.81 (d, 1H, J=8.71 Hz), 7.38 (t, 1H, J=7.2 Hz), 7.48 (t, 2H, J=7.2 Hz), 7.62-7.81 (m, 10H), 9.93 (brs, 1H). 
     I-137 
     mp: 291-292° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.25-1.39 (m, 2H), 1.41 (s, 9H), 1.61-1.80 (m, 2H), 2.01-2.36 (m, 5H), 3.32 (m, 1H), 3.63 (d, 1H, J=9.3 Hz), 7.20 (brs, 1H), 7.53-7.74 (m, 8H). 
     I-138 
     mp: 259-262° C. 
       1 H-NMR (CD 3 OD) δ ppm: 1.40 (s, 9H), 1.40-1.80 (m, 4H), 2.00-2.30 (m, 4H), 2.45 (m, 1H), 3.00 (s, 3H), 3.15-3.30 (m, 2H), 7.90 (d, 1H, J=8.4 Hz), 8.12 (d, 1H, J=9.0 Hz), 8.39 (d, 1H, J =9.0 Hz), 8.72 (s, 1H), 8.92 (d, 1H, J=8.4 Hz), 10.4 (s, 1H). 
     I-139 
     mp: 265-268° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.25-1.40 (m, 2H), 1.40 (s, 9H), 168-1.81 (m, 2H), 2.05-2.10 (m, 2H), 2.23-2.37 (m, 3H), 3.32 (m, 1H), 4.27 (d, 1H, J=9.1 Hz), 7.53 (t, 1H, J=7.9 Hz), 7.63 (td, 1H, J=7.9, 1.4 Hz), 7.77 (d, 1H, J=7.9 Hz), 8.03 (d, 1H, J=7.9 Hz), 8.37 (brs, 1H), 8.85-8.86 (m, 2H). 
     I-140 
     mp: 258-260° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.40 (m, 2H), 1.41 (s, 9H), 1.52-1.85 (m, 2H), 2.03-2.35 (m, 5H), 3.34 (m, 1H), 3.75 (m, 1H), 7.35-7.66 (m, 3H), 8.05 (d, 1H, J=9.0 Hz), 8.11 (d, 1H, J=9.0 Hz), 8.40 (brs, 1H), 8.83 (s, 1H). 
     I-141 
     mp: 205-206° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.37 (m, 2H), 1.40 (s, 9H), 1.43-1.62 (m, 2H), 1.90-2.01 (m, 2H), 2.02-2.23 (m, 3H), 3.27 (m, 1H), 3.63 (d, 1H, J=9.6 Hz), 3.70 (s, 3H), 6.64 (d, 1H, J=8.8 Hz), 7.28-7.41 (m, 5H), 7.45 (brs, 1H), 8.26 (d, 1H, J=8.8 Hz). 
     I-142 
     mp: 277-280° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.23-0.34 (m, 2H), 1.34 (s, 9H), 1.34-1.55 (m, 5H), 1.76-1.80 (m, 2H), 2.97 (m, 1H), 3.31 (d, 1H, J=9.6 Hz), 7.18 (s, 1H), 7.50-7.59 (m, 4H), 7.77 (dd, 1H, J=7.4, 1.0 Hz), 7.91-7.98 (m, 2H), 8.39 (dd, 1H, J=7.4, 1.9 Hz). 
     I-143 
     mp: 202-203° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.23-1.40 (m, 2H), 1.40 (s, 9H), 1.57-1.71 (m, 2H), 2.05-2.10 (m, 2H), 2.18-2.28 (m, 3H), 3.31 (m, 1H), 3.91 (s, 3H), 3.93 (s, 3H), 4.05 (d, 1H, J=9.5 Hz), 8.15 (s, 1H), 9.56 (s, 1H). 
     I-144 
     mp: 177-178° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.27-1.39 (m, 2H), 1.40 (s, 9H), 1.65-1.79 (m, 2H), 2.04-2.07 (m, 2H), 2.12-2.34 (m, 3H), 3.22 (m, 1H), 3.93 (d, 1H, J=9.1 Hz), 6.90-7.03 (m, 3H), 7.25 (m, 3H), 7.77 (dd, 1H, J=4.9, 1.7 Hz), 7.81 (brs, 1H), 8.72 (dd, 1H, J=7.8, 1.5 Hz), 
     I-145 
     mp: &gt;300° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.30 (s, 9H), 1.44-1.70 (m, 4H), 2.05-2.19 (m, 4H), 2.73 (m, 1H), 3.18 (m, 1H), 6.86 (d, 1H, J=8.8 Hz), 7.62 (t, 2H, J=8.5 Hz), 7.86 (t, 2H, J=8.5 Hz), 7.89 (d, 2H, J=8.5 Hz), 8.16 (d, 2H, J=8.5 Hz). 
     I-146 
     mp: 240-242° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.26-1.53 (m, 4H), 1.27 (s, 9H), 1.74-1.83 (m, 2H), 1.90-1.97 (m, 2H), 2.26 (m, 1H), 3.04 (m, 1H), 6.59 (brs, 1H), 6.74-6.79 (m, 3H), 7.74 (s, 1H), 10.32 (s, 1H), 12.80 (s, 1H). 
     I-147 
     mp: 167-169° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.05-1.28 (m, 2H), 1.38 (s, 9H), 1.47-1.70 (m, 2H), 1.80-2.00 (m, 3H), 2.13-2.25 (m, 2H), 2.75 (t, 2H, J=6.9 Hz), 3.24 (m, 1H), 3.49 (dt, 2H, J=6.3, 6.9 Hz), 3.58 (d, 1H, J=8.7 Hz), 3.87 (s, 6H), 5.40 (brs, 1H), 6.71 (m, 2H), 6.82 (d, 1H, J=8.7 Hz). 
     I-148 
     mp: 171-172° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.16-1.38 (m, 2H), 1.39 (s, 9H), 1.50-1.79 (m, 4H), 1.85-2.02 (m, 3H), 2.15-2.30 (m, 2H), 2.35-2.56 (m, 6H), 3.25 (m, 1H), 3.33 (q, 2H, J=6.0 Hz), 3.63 (d, 1H, J=9.0 Hz), 3.72 (t, 4H, J=4.6 Hz), 6.77 (brs, 1H). 
     I-149 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.36 (m, 2H), 1.28 (t, 3H, J=7.2 Hz), 1.39 (s, 9H), 1.45-1.70 (m, 2H), 1.85-2.30 (m, 7H), 2.43 (s, 3H), 3.05-3.42 (m, 3H), 3.46-3.80 (m, 3H), 7.31 (d, 1H, J=7.2 Hz), 7.40-7.52 (m, 3H), 8.18 (brs, 1H). 
     I-150 
     mp: 203-204° C. 
       1 H-MMR (CDCl 3 ) δ ppm: 1.15-1.37 (m, 2H), 1.39 (s, 9H), 1.42-1.70 (m, 2H), 1.85-2.29 (m, 5H), 2.76 (t, 2H, J=6.0 Hz), 3.26 (m, 1H), 3.49 (q, 2H, J=6.0 Hz), 3.61 (m, 1H), 4.03 (s, 2H), 5.88 (brs, 1H), 7.15, (dd, J=7.0, 8.8 Hz), 7.30-7.35 (m, 2H). 
     I-151 
     mp: 181-183° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.15-1.30 (m, 2H), 1.39 (s, 9H), 1.45-1.64 (m, 2H), 1.88-2.05 (m, 3H), 2.15-2.25 (m, 2H), 2.69 (t, 2H, J=6.0 Hz), 3.28 (m, 1H), 3.47 (q, 2H, J=6.0 Hz), 3.58 (d, 1H, J=9.9 Hz), 3.87 (s, 2H), 5.83 (brs, 1H), 7.00 (m, 1H), 7.20 (m, 2H). 
     I-152 
     mp: 222-224° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.16-1.37 (m, 2H), 1.39 (s, 9H), 1.49-1.70 (m, 2H), 1.90-2.25 (m, 5H), 3.26 (m, 1H), 3.36 (t, 2H, J=6.4 Hz), 3.66 (dt, 3H, J=6.0, 6.4 Hz), 5.87 (t, 1H, J=6.0 Hz), 7.58 (s, 1H), 7.68 (dd, 1H, J=7.0, 8.5 Hz), 7.83 (dd, 1H, J=7.0, 8.5 Hz), 8.19 (t, 2H, J=8.5 Hz). 
     I-153 
     mp: 207-209° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.05-1.25 (m, 2H), 1.38 (s, 9H), 1.40-2.03 (m, 10H), 2.05-2.25 (m, 2H), 2.58 (s, 3H), 2.76 (m, 1H), 3.05-3.35 (m, 2H), 3.97 (d, 1H, J=9.5 Hz), 4.94 (t, 1H, J=4.0 Hz), 8.42 (d, 1H, J=5.5 Hz), 8.97 (d, 1H, J=5.5 Hz). 
     I-154 
     mp: 1.84-185° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.05-1.25 (m, 2H), 1.37 (s, 9H), 1.50-1.69 (m, 2H), 1.85-2.05 (m, 3H), 2.10-2.21 (m, 2H), 3.24 (m, 1H), 3.64 (m, 1H), 4.87 (s, 1H), 4.88 (s, 1H), 5.67 (brs, 1H), 7.42 (d, 2H, J=5.5 Hz), 7.52 (m, 2H), 7.78 (m, 1H), 7.82 (m, 1H), 7.95 (d, 1H, J=7.0 Hz). 
     I-155 
     mp: 208-210° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.26 (s, 9H), 1.27-1.50 (m, 4H), 1.75-2.00 (m, 4H), 2.16 (m, 1H), 2.81 (s, 3H), 3.02 (m, 1H) 6.79 (d, 1H, J=8.5 Hz), 10.00 (s, 1H), 10.66 (s, 1H). 
     I-156 
     mp: 256-257° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.39 (m, 2H), 1.41 (s, 9H), 1.60-1.81 (m, 2H), 2.01-2.35 (m, 5H), 2.69 (t, 2H, J=6.0 Hz), 3.11 (t, 2H, J=6.0 Hz), 3.30 (m, 1H), 3.61 (d, 1H, J=9.3 Hz), 7.21 (d, 1H, J=8.0 Hz), 7.31 (s, 1H), 7.70 (d, 1H, J=8.0 Hz), 7.99 (s, 1H). 
     I-157 
     mp: 269-271° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.45 (m, 2H), 1.41 (s, 9H), 1.70-1.90 (m, 2H), 2.10-2.45 (m, 5H), 3.37 (m, 1H), 3.68 (m, 1H), 7.45 (dd, 1H, J=4.0, 8.0 Hz), 7.53 (brs, 1H), 7.72 (t, 1H, J=8.0 Hz), 7.83 (d, 1H, J=8.0 Hz), 8.02 (d, 1H, J=8.0 Hz), 8.18 (d, 1H, J=8.0 Hz), 8.93 (d, 1H, J=4.0 Hz). 
     I-158 
     mp: 253-255° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.40 (m, 2H), 1.42 (s, 9H), 1.60-1.90 (m, 2H), 2.06-2.50 (m, 5H), 2.72 (s, 3H), 3.33 (m, 1H), 3.78 (d, 1H, J=9.2 Hz), 7.52 (t, 1H, J=7.0 Hz), 7.62-7.80 (m, 2H), 7.94 (brs, 1H), 8.05 (d, 1H, J=8.5 Hz), 8.20 (s, 1H). 
     I-159 
     mp: 253-255° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.39 (m, 2H), 1.40 (s, 9H), 1.60-1.80 (m, 2H), 1.98-2.30 (m, 5H), 2.71 (s, 3H), 3.31 (m, 1H), 3.68 (d, 1H, J=9.0 Hz), 7.41 (brs, 1H), 7.61 (d, 2H, J=9.0 Hz), 7.70 (d, 2H, J=9.0 Hz), 
     I-160 
     mp: 211-212° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.32 (m, 2H), 1.39 (t, 3H, J=7.0 Hz), 1.40 (s, 9H), 1.55-1.79 (m, 2H), 1.98-2.35 (m, 5H), 3.31 (m, 1H), 3.65 (d, 1H, J=9.5 Hz), 4.03 (q, 2H, J=7.0 Hz), 6.64 (d, 1H, J=8.0 Hz), 6.92 (d, 1H, J=8.0 Hz), 7.10 (s, 1H), 7.19 (t, 1H, J=8.0 Hz), 7.30 (brs, 1H). 
     I-161 
     mp: 202-203° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.96 (t, 1H, J=7.3 Hz), 1.29-1.39 (m, 2H), 1.40 (s, 9H), 1.41-1.58 (m, 2H), 1.60-1.80 (m, 4H), 1.98-2.31 (m, 5H), 3.31 (m, 1H), 3.66 (d, 1H, J=8.5 Hz), 3.96 (t, 2H, J=6.4 Hz), 6.64 (d, 1H, J=8.0 Hz), 6.90 (d, 1H, J=8.0 Hz), 7.11 (s, 1H), 7.19 (t, 1H, J =8.0 Hz), 7.81 (brs, 1H). 
     I-162 
     mp: 177-180° C. 
       1 H-NMR, (CDCl 3 ) δ ppm: 1.18-1.38 (m, 2H), 1.39 (s, 9H), 1.59-1.78 (m, 2H), 1.95-2.05 (m, 2H), 2.07-2.25 (m, 3H), 3.26 (m, 1H), 3.46 (s, 3H), 4.17 (d, 1H, J=9.5 Hz), 5.15 (s, 2H), 6.77 (d, 1H, J=8.0 Hz), 7.10-7.23 (m, 2H), 7.34 (s, 1H), 7.58 (s, 1H), 
     I-163 
     mp: 175-178° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.28-1.50 (m, 4H), 1.78-2.00 (m, 4H), 2.22 (m, 1H), 2.96-3.15 (m, 2H), 6.67 (m, 1H), 6.79 (d, 1H, J=8.5 Hz), 7.18 (m, 2H), 7.38 (s, 1H), 9.81 (s, 1H). 
     I-164 
     mp: 232-233° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.97 (t, 3H, J=7.3 Hz), 1.22-1.30 (m, 2H), 1.40 (s, 9H), 1.44-1.51 (2H), 1.67-1.77 (m, 4H), 2.02-2.24 (m, 5H), 3.22 (m, 1H), 3.62 (d, 1H, J=9.6 Hz), 4.25 (t, 2H, J=6.8 Hz), 6.71 (d, 1H, J=8.4 Hz), 7.01 (brs, 1H), 7.91 (dd, 1H, J=8.4, 3.3 Hz), 8.08 (d, 1H, J=3.3 Hz). 
     I-165 
     mp: 199-200° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.96 (t, 3H, J=7.4 Hz), 1.24-1.50 (m, 4H), 1.40 (s, 9H), 1.67-1.76 (m, 3H), 2.03-2.08 (m, 2H), 2.24-2.35 (m, 3H), 3.29 (m, 1H), 3.76 (d, 1H, J=9.1 Hz), 3.91 (t, 2H, J=6.6 Hz), 6.41 (dd, 1H, J=8.8, 2.5 Hz), 6.55 (d, 1H, J=2.5 Hz), 6.82 (d, 1H, J=8.8Hz), 7.43 (s, 1H) 8.95 (s, 1H). 
     I-166 1H), 7.15 (m, 2H), 7.28 (m, 1H), 7.45 (m, 2H), 7.84 (brs, 1H). 
     I-171 
     mp: 173-174° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.98 (t, 3H, J=7.5 Hz), 1.29-1.40 (m, 2H), 1.40 (s, 9H), 1.55 (m, 2H), 1.62-1.83 (m, 4H), 2.09-2.12 (m, 2H), 2.24-2.32 (m, 3H), 3.32 (m, 1H), 3.63 (d, 1H, J=9.5 Hz), 3.99 (t, 2H, J=6.4 Hz), 7.22 (dd, 1H, J=9.4, 2.7 Hz), 7.66 (d, 1H, J=2.7 Hz), 8.63 (d, 1H, J=9.4 Hz), 10.17 (s, 1H). 
     I-172 
     mp: 238-242° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.96 (t, 3H, J=7.3 Hz), 1.23-1.52 (m, 4H), 1.40 (s, 9H), 1.61-1.78 (m, 4H), 2.05-2.28 (m, 5H), 3.30 (m, 1H), 3.66 (d, 1H, J=9.4 Hz), 3.84 (brs, 2H), 3.90 (t, 2H, J=6.4 Hz), 6.32-6.35 (m, 2H), 6.96 (brs, 1H), 6.97 (d, 1H, J=9.4 Hz). 
     I-173 
     mp: 165-166° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.23-1.26 (m, 2H), 1.40 (s, 9H), 1.67-1.72 (m, 2H), 2.01-2.06 (m, 2H), 2.11-2.28 (m, 3H), 3.31 (m, 1H), 3.60 (s, 2H), 3.69 (s, 3H), 4.02 (brs, 1H), 7.01 (d, 1H, J=8.0 Hz), 7.25 (t, 1H, J=8.0 Hz), 7.43 (d, 1H, J=8.0 Hz), 7.49 (brs, 1H), 7.51 (brs, 1H). 
     I-174 
     mp: 264-265° C. 
       1 H-NMR (CDCl 3 +CD 3 OD) δ ppm: 1.26-1.29 (m, 2H), 1.39 (s, 9H), 1.62-1.69 (m, 2H), 1.96-2.00 (m, 2H), 2.18-2.21 (m, 3H), 3.25 (m, 1H), 3.58 (s, 2H), 7.01 (d, 1H, J=7.5 Hz), 7.26 (t, 1H, J=7.5 Hz), 7.42 (brs, 1H), 7.50 (d, 1H, J=7.5 Hz). 
     I-175 
     mp: 90-94° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.16-1.23 (m, 2H), 1.37 (s, 9H), 1.44-1.56 (m, 2H), 1.73-1.85 (m, 3H), 2.11-2.15 (m, 2H), 3.57 (t, 2H, J=6.4 Hz), 3.21 (m, 1H), 3.58 (m, 2H), 3.84 (d, 1H, J=9.3 Hz), 5.56 (brs, 1H), 7.01 (s, 1H), 7.11 (t, 1H, J=7.5 Hz), 7.21 (t, 1H, J=7.5 Hz), 7.38 (d, 1H, J=7.5 Hz), 7.59 (d, 1H, J=7.5 Hz), 8.24 (brs, 1H). 
     I-176 
     mp: 116-118° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.18-1.38 (m, 2H), 1.40 (s, 9H), 1.60-1.79 (m, 2H), 1.95-2.30 (m, 5H), 3.30 (m, 1H), 3.69 (m, 1H), 3.80 (s, 3H), 4.64 (s, 2H), 6.67 (d, 1H, J=8.0 Hz), 7.00 (d, 1H, J=8.5 Hz), 7.15-7.24 (m, 2H), 7.32 (brs, 1H). 
     I-177 
     mp: 219-220° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.28-1.50 (m, 4H), 1.75-2.01 (m, 4H), 2.18-2.30 (m, 1H), 2.95-3.15 (m, 2H), 4.61 (s, 2H), 6.56 (m, 1H), 6.80 (d, 1H, J=8.5 Hz), 7.16 (m, 2H), 7.28 (brs, 1H), 9.87 (brs, 1H). 
     I-178 
     mp: 170-173° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.18-1.39 (m, 2H), 1.40 (s, 9H), 1.50-1.80 (m, 2H), 1.90-2.33 (m, 5H), 2.36 (s, 6H), 2.75 (t, 2H, J=5.5 Hz), 3.30 (m, 1H), 3.70 (m, 1H), 4.08 (t, 2H, J 5.5 Hz), 6.68 (d, 1H, J=8.0 Hz), 6.94 (d, 1H, J=7.5 Hz), 7.15-7.23 (m, 2H), 7.33 (brs, 1H). 
     I-179 
     mp: 191-193° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.39 (m, 2H), 1.40 (s, 9H), 1.58-1.80 (m, 2H), 1.98-2.32 (m, 5H), 3.30 (m, 1H), 3.70 (d, 1H, J=9.5 Hz), 4.77 (s, 2H), 6.73 (d, 1H, J=8.0 Hz), 7.04 (d, 1H, J=8.0 Hz), 7.20-7.31 (m, 2H), 7.48 (brs, 1H). 
     I-180 
     mp: 174-176° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.10-1.30 (m, 2H), 1.40 (s, 9H), 1.45-1.65 (m, 2H), 1.81-2.02 (m, 3H), 2.15-2.30 (m, 2H), 2.58 (t, 2H, J=6.5 Hz), 3.25 (m, 1H), 3.37 (dt, 2H, J=5.5, 6.5 Hz), 3.60 (d, 1H, J=9.5 Hz), 3.71 (s, 2H), 5.73 (brs, 1H), 7.20-7.40 (m, 5H), 
     I-181 
     mp 176-178° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.15-1.30 (m, 2H), 1.39 (s, 9H), 1.45-1.70 (m, 6H), 1.85-2.01 (m, 3H), 2.15-2.28 (m, 2H), 2.63 (t, 2H, J=7.0 Hz), 3.25 (dt, 2H, J=6.0, 7.0 Hz), 3.27 (m, 1H), 3.63 (m, 1H), 5.35 (brs, 1H), 7.17 (m, 3H), 7.29 (m, 2H). 
     I-182 
     mp: 152-154° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.15-1.30 (m, 2H), 1.39 (s, 9H), 1.45-1.65 (m, 2H), 1.85-2.05 (m, 3H), 2.09-2.25 (m, 2H), 3.25 (m, 1H), 3.45 (dt, 2H, J=5.0, 5.0 Hz), 3.55 (t, 2H, J=5.0 Hz), 3.60 (m, 1H), 4.51 (s, 2H), 5.81 (brs, 1H), 7.29-7.40 (m, 5H). 
     I-183 
     mp: 208-211° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.31 (m, 2H), 1.39 (s, 9H), 1.62-1.68 (m, 2H), 1.98-2.25 (m, 5H), 3.30 (m, 1H), 3.57 (d, 1H, J=9.2 Hz), 4.59 (d, 2H, J=5.8 Hz), 5.76 (brs, 1H), 7.37 (dd, 1H, J=8.4, 2.0 Hz), 7.46-7.52 (m, 2H), 7.69 (brs, 1H), 7.78-7.83 (m, 3H). 
     I-184 
     mp: 180-182° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22-1.37 (m, 2H), 1.40 (s, 9H), 1.60-1.69 (m, 2H), 2.05-2.09 (m, 2H), 2.21-2.27 (m, 3H), 3.45 (m, 1H), 3.64 (d, 1H, J=9.6 Hz), 4.77 (d, 2H, J=4.9 Hz), 7.43 (d, 1H, J=8.6 Hz), 7.46 (brs, 1H), 7.61 (t, 1H, J=7.7 Hz), 7.73 (t, 1, 1H, J=7.7 Hz), 7.87 (t, 1H, J=7.7 Hz), 8.20 (t, 1H, J=7.7 Hz), 8.24 (d, 1H, J=8.6 Hz). 
     I-185 
     mp: 260-261° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22-1.32 (m, 2H), 1.39 (s, 9H), 1.60-1.70 (m, 2H), 1.97-2.01 (m, 2H), 2.11 (m, 1H), 2.21-2.24 (m, 2H), 3.30 (m, 1H), 3.61 (d, 1H, J=9.3 Hz), 4.95 (d, 2H, J=6.0 Hz), 5.85 (brs, 1H), 7.33 (d, 1H, J=4.8 Hz), 7.62 (dd, 1H, J=8.4, 6.9 Hz), 7.75 (dd, 1H, J=8.1, 6.9 Hz), 8.00 (d, 1H, J=8.1 Hz), 8.20 (d, 1H, J=8.4 Hz), 8.42 (d, 1H, J=4.8 Hz). 
     I-186 
     mp: 231-233° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.23-1.40 (m, 2H), 1.40 (s, 9H), 1.62-1.76 (m, 2H), 2.04-2.10 (m, 2H), 2.22-2.32 (m, 3H), 3.30 (m, 1H), 3.95 (d, 1H, J=9.3 Hz), 5.04 (d, 2H, J=4.1 Hz), 7.61 (d, 1H, J=5.8 Hz), 7.63 (brs, 1H), 7.65 (dd, 1H, J=8.2, 6.9 Hz), 7.73 (dd, 1H, J=8.5, 6.9 Hz), 7.86 (d, 1H, J=8.2 Hz), 8.10 (d, 1H, J=8.5 Hz), 8.42 (d, 1H, J=5.8 Hz). 
     I-187 
     mp: 184-187° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.97 (t, 3H, J=7.3 Hz), 1.18-1.30 (m, 2H), 1.39 (s, 9H), 1.42-1.65 (m, 4H), 1.70-1.80 (m, 2H), 1.94-2.08 (m, 3H), 2.18-2.26 (m, 2H), 3.29 (m, 1H), 3.61 (d, 1H, J=9.5 Hz), 3.93 (t, 2H, J=6.4 Hz), 4.39 (d, 2H, J=5.5 Hz), 5.67 (brs, 1H), 6.79-6.83 (m, 3H), 7.23 (t, 1H, J=7.6 Hz). 
     I-188 
     mp: 224-226° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 16-1.31 (m, 2H),1.38 (s, 9H), 1.55-1.70 (m, 2H), 1.92-2.07 (m, 3H), 2.17-2.23 (m, 2H), 3.21 (m, 1H), 3.81 (s, 3H), 3.83 (s, 6H), 4.05 (d, 1H, J=9.8 Hz), 4.34 (d, 2H, J=5.8 Hz), 5.96 (brs, 1H), 6.47 (s, 2H). 
     I-189 
     mp: 217-218° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.15-1.30 (m, 2H), 1.37 (s, 9H), 1.52-1.66 (m, 2H), 1.90-2.06 (m, 3H), 2.13-2.20 (m, 2H), 2.93 (s, 6H), 3.24 (m, 1H), 3.94 (d, 1H, J=9.5 Hz), 4.30 (d, 2H, J=5.5 Hz), 5.73 (brs, 1H), 6.69 (d, 2H, J=8.9 Hz), 7.12 (d, 2H, J=8.9 Hz). 
     I-190 
     mp: amorphous solid 
       1 H-NMR (CDCl 3 ) δ ppm: 1.17-1.32 (m, 2H), 1.39 (s, 9H), 1.54-1.72 (m, 2H), 1.96-2.13 (m, 3H), 2.18-2.27 (m, 2H), 3.30 (m, 1H), 3.63 (d, 1H, J=9.2 Hz), 4.51 (d, 2H, J=5.8 Hz), 5.82 (brs, 1H), 7.40 (d, 2H, J=8.5 Hz), 8.02 (d, 2H, J=8.5 Hz), 8.64 (s, 1H). 
     I-191 
     mp: 126-128° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.97 (t, 3H, J=7.4 Hz), 1.10-1.28 (m, 2H), 1.36 (s, 9H), 1.42-1.86 (m, 9H), 2.06-2.18 (m, 2H), 3.22 (m, 1H), 3.95 (t, 2H, J=4.5 Hz), 4.16 (brs, 1H), 4.85 (s, 2H), 6.82-6.95 (m, 3H), 7.26 (t, 1H, J=7.8 Hz), 8.54 (brs, 1H). 
     I-192 
     mp: 178-181° C. 
       1 H-MMR (CDCl 3 ) δ ppm: 0.96 (t, 3H, J=7.3 Hz), 1.18-1.52 (m, 4H), 1.39 (s, 9H), 1.58-1.76 (m, 4H), 1.92-2.00 (m, 2H), 2.02-2.29 (m, 3H), 3.28 (m, 1H), 3.78 (d, 1H, J=9.5 Hz), 3.39 (t, 2H, J=6.6 Hz), 6.00 (brs, 1H), 6.78 (s, 4H), 7.35 (brs, 1H). 
     I-193 
     mp: 187-188° C. 
       1 H-NMR (CDCl 3 +CD 3 OD) δ ppm: 1.21-1.40 (m, 2H), 1.38 (s, 9H), 1.52-1.69 (m, 2H), 1.90-2.00 (m, 21H), 2.02-2.20 (m, 3H), 3.22 (m, 1H), 3.75 (s, 3H), 6.79 (s, 4H). 
     I-194 
     mp: 251-253° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.24-1.50 (m, 4H), 1.72-1.83 (m, 2H), 1.91-1.99 (m, 2H), 2.16 (m, 1H), 3.02 (m, 1H), 3.82 (s, 3H), 6.79 (d, 1H, J=8.2 Hz), 7.01 (d, 2H, J=8.8 Hz), 7.85 (d, 2H, J=8.8 Hz), 9.72 (brs, 1H), 8.64 (brs, 1H). 
     I-195 
     mp: 183-185° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22-1.37 (m, 2H), 1.40 (s, 9H), 1.58-1.75 (m, 2H), 2.05-2.10 (m, 2H), 2.20-2.30 (m, 3H), 3.32 (m, 1H), 3.70 (s, 2H), 3.73 (s, 3H), 6.79 (s, 1H), 8.83 (brs, 1H). 
     I-196 
     mp: 185-187° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.39 (m, 2H), 1.40 (s, 9H), 1.44 (t, 6H, J=7.0 Hz), 1.60-1.80 (m, 2H), 1.95-2.35 (m, 5H), 3.30 (m, 1H), 3.62 (d, 1H, J=8.9 Hz), 4.06 (q, 2H, J=7.0 Hz), 4.09 (q, 2H, J=7.0 Hz), 6.08 (s, 1H), 7.02 (s, 1H), 7.36 (s, 1H). 
     I-197 
     mp: 211-213° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.40 (m, 2H), 1.41 (s, 9H), 1.60-1.80 (m, 2H), 2.00-2.36 (m, 5H), 2.61 (s, 3H), 3.32 (m, 1H), 3.64 (d, 1H, J=9.2 Hz), 7.28 (s, 1H), 7.43 (t, 1H, J=7.5 Hz), 7.69 (d, 1H, J=7.5 Hz), 7.85 (d, 1H, J=7.5 Hz), 8.02 (s, 1H). 
     I-198 
     mp: 268-269° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.39 (m, 2H), 1.40 (s, 9H), 1.42-2.32 (m, 7H), 2.90-3.10 (m, 4H), 3.30 (m, 1H), 3.68 (d, 1H, J=8.8 Hz), 6.59 (s, 1H), 7.18 (d, 1H, J=8.7 Hz), 7.59 (d, 1H, J=8.7 Hz), 7.77 (brs, 1H). 
     I-199 mp: 221-224° C. 
     I-200 mp: 237-240° C. 
     I-201 mp: 87-90° C. 
     I-202 mp: 222-223° C. 
     I-203 mp: 255-257° C. 
     I-204 mp: 234-236° C. 
     I-205 mp: 208-210° C. 
     I-206 mp: 217-218° C. 
     I-207 mp: 275-279° C. 
     I-208 mp: 248-250° C. 
     I-209 mp: 256-258° C. 
     I-210 mp: 270-271° C. 
     I-211 mp: 219-220° C. 
     I-212 mp: 260-261° C. 
     I-213 mp: &gt;300° C. 
     I-214 mp: 206-207° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.4 Hz), 1.30-1.42 (m, 2H), 1.49 (d, 6H, J=6.9 Hz), 1.53-1.65 (m, 2H), 2.61 (t, 2H, J=7.7 Hz), 4.15 (sept, 1H, J=6.9 Hz), 7.04 (d, 1H, J=8.2 Hz), 7.20 (d, 2H, J=8.2 Hz), 7.51 (d, 2H, J=8.2 Hz), 7.89 (d, 1H, J=8.8 Hz), 8.18 (s, 1H), 10.55 (s, 1H). 
     I-215 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (t, 3H, J=7.3 Hz), 1.30-1.41 (m, 2H), 1.52-1.63 (m, 2H), 1.95 (s, 6H), 2.61 (t, 2H, J=7.8 Hz), 6.99 (brs, 1H), 7.20 (d, 2H, J=8.5 Hz), 7.65 (d, 2H, J=8.5 Hz), 7.93 (dd, 1H, J=8.5, 2.5 Hz), 8.28 (d, 1H, J=8.5 Hz), 8.55 (d, 1H, J=2.5 Hz), 9.76 (brs, 1H). 
     Ia-1 
     mp 221-224° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.19-1.38 (m, 2H), 1.40 (s, 9H), 1.62-1.77 (m, 2H), 2.00-2.31 (m, 5H), 3.18 (t, 4H, J=4.8 Hz), 3.21-3.38 (m, 1H), 3.85 (t, 4H, J=4.8 Hz), 6.64-6.32 (m, 2H), 7.11 (s, 1H), 7.20 (t, 1H, J=7.8 Hz), 7.45 (s, 1H). 
     Ia-3 
     mp 87-90° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.25 (d, 6H, J=6.3 Hz), 1.37 (d, 6H, J=6.9 Hz), 1.59-1.70 (m, 2H), 1.76-1.88 (m, 2H), 2.32-2.42 (m, 4H), 3.11-3.23 (m, 3.39 (d, 2H, J=10.8 Hz), 3.74-3.86 (m, 2H), 4.34 (t, 1H, J=9.0 Hz), 6.86 (d, 2H, J=9.0 Hz), 7.30 (s, 1H), 7.40 (d, 2H, J=9.0 Hz). 
     Ia-4 
     mp 233-234° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.25 (d, 6H, J=6.3 Hz), 1.40 (s, 9H), 1.26-1.37 (m, 2H), 1.62-1.78 (m, 2H), 2.00-2.22 (m, 5H), 2.42 (t, 2H, J=11.7 Hz), 3.20-3.40 (m, 1H), 3.46 (d, 2H, J=10.5 Hz), 3.67 (d, 1H, J=9.3 Hz), 3.72-3.84 (m, 2H), 6.62-6.76 (m, 2H), 7.10 (s, 1H), 7.18 (t, 1H, J=7.8 Hz), 7.42 (s, 1H). 
     Ia-5 
     mp 125-126° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.25 (d, 6H, J=6.3 Hz), 1.40 (s, 9H), 1.59-1.70 (m, 2H), 1.77-1.84 (m, 2H), 2.30-2.46 (m, 4H), 3.24 (q, 2H, J=6.6 Hz), 3.38 (d, 2H, J=11.7 Hz), 3.74-3.88 (m, 2H), 4.08 (t, 1H, J=5.7 Hz), 6.87 (d, 2H, J=8.7 Hz), 7.30 (s, 1H), 7.41 (d, 2H, J=8.7 Hz), 
     Ia-6 
     mp 229-230° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.25 (d, 6H, J=6.3 Hz), 1.26-1.34 (m, 2H), 1.39 (d, 6H, J=6.9 Hz), 1.61-1.77 (m, 2H), 1.98-1.26 (m, 5H), 2.32-2.46 (m, 2H), 3.15 (quintet, 1H, J=6.6 Hz), 3.22-3.35 (m, 1H), 3.39 (d, 2H, J=11.4 Hz), 3.74-3.92 (m, 2H), 3.88 (d, 1H, J=8.4 Hz), 6.96-6.71 (m, 2H), 7.05 (brs, 1H), 7.39 (d, 2H, J=9.3 Hz). 
     Ia-7 
     mp 253-254° C. 
       1 H-NMR (DMSO) δ ppm: 1.24-1.60 (m, 4H), 1.27 (s, 9H), 1.77-2.07 (m, 4H), 2.16-2.34 (m, 1H), 2.97-3.15 (m, 1H), 6.78 (d, 1H, J=7.2 Hz), 7.01 (t, 1H, J=6.0 Hz), 7.27 (t, 2H, J=6.6 Hz), 7.58 (d, 2H, J=7.5 Hz), 9.78 (s, 1H). 
     Ia-8 
     mp 257-258° C. 
       1 H-NMR (DMSO) δ ppm: 1.22-1.54 (m, 4H), 1.27 (s, 9H) 1.77-1.88 (m, 2H), 1.88-2.00 (m, 2H), 2.16-2.34 (m, 1H), 2.23 (s, 3H), 2.92-3.14 (m, 1H), 6.77 (d, 1H, J=8.4 Hz), 7.07 (d, 2H, J=8.4 Hz), 7.46 (d, 2H, J=8.1 Hz), 9.68 (s, 1H). 
     Ia-9 
     mp 231-232° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.21 (t, 3H, J=7.5 Hz), 1.22-1.38 (m, 2H), 1.40 (s, 9H), 1.62-1.78 (m, 2H), 1.98-2.31 (m, 5H), 2.61 (q, 2H, J=7.5 Hz), 3.24-3.38 (m, 1H), 3.70 (d, 1H, J=9.9 Hz), 7.11 (s, 1H), 7.14 (d, 2H, J=8.7 Hz), 7.40 (d, 2H, J=8.7 Hz). 
     Ia-10 
     mp 233-234° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.96 (t, 31-1, J=7.2 Hz), 1.20-1.37 (m, 2H), 1.40 (s, 9H), 1.56-1.78 (m, 4H), 1.98-2.32 (m, 5H), 2.54 (t, 2H, J=7.2 Hz), 3.23-3.39 (m, 1H), 3.66 (d, 1H, J=9.6 Hz), 7.08 (s, 1H), 7.12 (d, 2H, J=8.4 Hz), 7.39 (d, 2H, J=8.4 Hz). 
     Ia-11 
     mp 243-244° C. 
       1 H-NMR (CDCL 3 ) δ ppm:1.22 (d, 6H, J=6.9), 1.22-1.77 (m, 4H), 1.40 (s, 9H), 2.01-2.30 (m, 5H), 2.83-2.92 (m, 1H), 3.24-3.40 (m, 1H), 3.66-3.69 (m, 1H), 7.09 (s, 1H), 7.17 (d, 2H, J=8.4Hz), 7.41 (d, 2H, J=8.1 Hz). 
     Ia-12 
     mp 246-247° C. 
       1 H-NMR (CDCL 3 ) δ ppm: 0.80 (t, 3H, J=7.5), 1.20 (d, 3H, J=7.2), 1.26-1.77 (m, 6H), 1.40 (s, 9H), 2.01-2.27 (m, 5H), 2.51-2.60 (m, 1H), 3.20-3.38 (m, 1H), 3.64-3.69 (m, 1H), 7.08 (s, 1H), 7.12 (d, 2H, J=8.4Hz), 7.41 (d, 2H, J=8.4Hz). 
     Ia-13 
     mp 278-279° C. 
       1 H-NMR (CDCL 3 ) δ ppm:1.22-1.52 (m, 4H), 1.29 (s, 9H), 1.61-1.77 (m, 2H), 2.02-2.30 (m, 5H), 3.20-3.38 (m, 1H), 3.66-3.69 (m, 1H), 7.10 (s, 1H), 7.33 (d, 2H, J=9.0 Hz), 7.42 (d, 2H, J=8.7 Hz). 
     Ia-14 
     mp 263-264° C. 
       1 H-NMR (DMSO) δ ppm: 1.24-1.51 (m, 4H), 1.27 (s, 9H), 1.82-1.99 (m, 4H), 2.19-2.28 (m, 1H), 2.98-3.12 (m, 1H), 6.78 (d, 1H, J=8.7 Hz), 7.33 (d, 2H, J=8.7 Hz), 7.61 (d, 2H, J=9.0 Hz), 9.94 (s, 1H). 
     Ia-15 
     mp 209-210° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.25 (d, 6H, J=6.3 Hz), 1.40 (s, 9H), 1.70-1.98 (m, 8H), 2.19-2.38 (m, 3H), 3.39 (d, 2H, J=11.7 Hz), 3.58-3.92 (m, 3H), 4.12-4.26 (m, 1H), 6.82-6.96 (m, 2H), 7.10 (br, 1H), 7.41 (d, 2H, J=8.1 Hz). 
     Ia-16 
     mp 238-240° C. 
       1 H-NMR (DMSO) δ ppm: 1.22-1.52 (m, 4H), 1.27 (s, 9H), 1.81-1.84 (m, 2H), 1.93-1.97 (m, 2H), 2.16-2.23 (m, 1H), 2.95-3.12 (m, 1H), 3.70 (s, 3H), 6.77 (d, 1H, J=8.4 Hz), 6.85(d, 2H, J=9.0 Hz), 7.48 (d, 2H, J=9.3 Hz), 9.64 (s, 1H). 
     Ia-17 
     mp 245-246° C. 
       1 H-NMR (DMSO) δ ppm: 1.22-1.52 (m, 4H), 1.27 (s, 9H), 1.83-1.87 (m, 2H), 1.94-1.99 (m, 2H), 2.20-2.28 (m, 1H), 2.98-3.12 (m, 1H), 6.78 (d, 1H, J=8.7 Hz), 7.28 (d, 2H, J=8.7 Hz), 7.69 (d, 2H, J=9.0 Hz), 9.64 (s, 1H). 
     Ia-18 
     mp 240-241° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22-1.78 (m, 4H), 1.40 (s, 9H), 2.05-2.33 (m, 5H),3.22-3.44 (m, 1H), 3.64-3.67 (m, 1H), 6.61 (s, 1H), 6.69-6.77 (m, 2H). 
     Ia-19 
     mp 240-241° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.24-1.77 (m, 4H), 1.40 (s, 9H), 2.05-2.30 (m, 5H), 3.22-3.38 (m, 1H), 3.70-3.74 (m, 1H), 7.00-7.15 (m, 3H), 7.36 (s, 1H), 8.29-8.34 (m, 1H). 
     Ia-20 
     mp 239-240° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.24-1.78 (m, 4H), 1.40 (s, 9H), 2.02-2.30 (m, 5H), 3.22-3.40 (m, 1H), 3.63-3.66 (m, 1H), 6.89-6.84 (m, 1H), 7.10-7.17 (m, 2H), 7.22-7.34 (m, 1H), 7.48-7.51 (m, 1H). 
     Ia-21 
     mp 259-260° C. 
       1 H-NMR (CDCl 3 /DMSO) δ ppm: 1.21 (d, 6H, J=6.0 Hz), 1.22-1.44 (m, 2H), 1.40 (s, 9H), 1.60-1.78 (m, 2H), 1.87-2.03 (m, 2H), 2.08-2.29 (m, 3H), 2.39 (t, 2H, J=10.2 Hz), 3.14-3.32 (m, 1H), 3.19 (d, 2H, J=11.4 Hz), 3.77-3.93 (m, 2H), 5.33 (d, 1H, J=9.0 Hz), 6.84 (dd, 1H, JFH, HH=8.1, 8.1 Hz), 7.20 (d, 1H, J=7.8 Hz), 7.49 (d, 1H, JFH=14.7 Hz), 8.86 (s, 1H). 
     Ia-22 
     mp 234-235° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20 (d, 6H, J=5.7 Hz), 1.22-1.44 (m, 2H), 1.38 (s, 9H), 1.54-1.76 (m, 2H), 1.94-2.32 (m, 5H), 2.27 (s, 3H), 2.39 (t, 2H, J=10.8 Hz), 2.87 (d, 2H, J=11.4 Hz), 3.20-3.40 (m, 1H), 3.76-3.92 (m, 2H), 3.91 (d, 1H, J=9.3 Hz), 6.93 (d, 1H, J=8.1 Hz), 7.21 (brs, 1H), 7.27 (brs, 1H), 7.36 (brs, 1H). 
     Ia-23 
     mp 195-196° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.44 (m, 4H), 1.41 (s, 9H), 1.59-1.76 (m, 2H), 2.03-2.14 (m, 2H), 2.15-2.33 (m, 3H), 3.20-3.40 (m, 1H), 3.64 (s, 1H, J=9.0 Hz), 7.19-7.24 (m, 1H), 7.44 (brs, 1H), 7.52-7.63 (m, 2H), 8.17 (d, 1H, J=8.7 Hz). 
     Ia-24 
     mp 209-210° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22-1.39 (m, 2H), 1.56 (s, 9H), 1.61-1.78 (m, 2H), 2.00-2.12 (m, 2H), 2.17-2.33 (m, 3H), 3.24-3.39 (m, 1H), 3.67 (d, 1H, J=9.6 Hz), 6.90-7.01 (m, 1H), 7.21 (s, 1H), 7.95-8.06 (m, 1H). 
     Ia-25 
     mp 278-281° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.10 (d, 6H, J=6.3 Hz), 1.27 (s, 9H), 1.28-1.55 (m, 4H), 1.78-2.00 (m, 4H), 2.11-2.26 (m, 1H), 2.31 (t, 2H, J=11.1 Hz), 3.00-3.10 (m, 1H), 3.08 (d, 1H, J=10.8 Hz), 3.67-3.80 (m, 2H), 6.78 (d, 1H, J=8.7 Hz), 7.08 (d, 1H, J=9.0 Hz), 7.41 (dd, 1H, J=2.4, 8.7 Hz), 7.78 (d, 1H, J=8.7 Hz), 9.85 (s, 1H). 
     Ia-26 
     mp 253-255° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.13 (d, 6H, J=6.0 Hz), 1.27 (s, 9H), 1.28-1.52 (m, 4H), 1.78-2.00 (m, 4H), 2.21 (t, 2H, J=11.1 Hz), 2.26-2.36 (m, 1H), 2.96-3.10 (m, 1H), 3.56 (d, 1H, J=12.3 Hz), 3.60-3.72 (m, 2H), 6.66-6.84 (m, 4H), 7.47 (t, 1H, J=9.3 Hz), 9.28 (s, 1H). 
     Ia-27 
     mp 223-226° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.09 (d, 6H, J=6.3 Hz), 1.27 (s, 9H), 1.28-1.54 (m, 4H), 1.77-2.01 (m, 4H), 2.32 (t, 2H, J=11.1 Hz), 2.32-2.42 (m, 1H), 2.90 (d, 1H, J=11.4 Hz), 2.96-3.12 (m, 1H), 3.76-3.92 (m, 2H), 6.78-6.98 (m, 3H), 7.68 (dd, 1H, J=3.3, 8.7 Hz), 8.84 (s, 1H). 
     Ia-28 
     mp 237-238° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22-1.44 (m, 2H), 1.25 (d, 6H, J=6.3 Hz), 1.40 (s, 9H), 1.61-1.79 (m, 2H), 2.05-2.32 (m, 5H), 2.21 (s, 3H), 2.38 (t, 2H, J=10.2 Hz), 3.22-3.42 (m, 1H), 3.40 (d, 2H, J=11.1 Hz), 3.65 (d, 1H, J=9.3 Hz), 3.72-3.90 (m, 2H), 6.70-6.78 (m, 2H), 6.81 (brs, 1H), 7.50 (d, 1H, J=9.6 Hz). 
     Ia-29 
     mp 208-209° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22 (d, 6H, J=6.0 Hz), 1.23-1.40 (m, 2H), 1.40 (s, 9H), 1.60-1.78 (m, 2H), 2.00-2.16 (m, 2H), 2.14-2.33 (m, 3H), 2.45 (t, 2H, J=11.1 Hz), 3.21 (d, 2H, J=10.8 Hz), 3.24-3.38 (m, 1H), 3.63 (d, 1H, J=9.3 Hz), 3.80-3.94 (m, 2H), 5.33 (d, 1H, J=9.0 Hz), 6.66 (dd, 1H, JFH, HH=6.6, 6.6 Hz), 7.16 (brs, 1H), 7.89 (dd, 1H, JFH, HH=9.0, 9.0 Hz). 
     Ia-30 
     mp 284-287° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.08 (d, 6H, J=6.0 Hz), 1.26 (s, 9H), 1.28-1.53 (m, 4H), 1.82-2.22 (m, 4H), 2.25-2.39 (m, 1H), 2.78 (t, 2H, J=10.5 Hz), 2.97-3.14 (m, 1H), 3.18 (d, 2H, J=11.4 Hz), 3.65-3.76 (m, 2H), 6.79 (d, 1H, J=8.7 Hz), 9.75 (s, 1H). 
     Ia-31 
     mp 200-201° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22-1.40 (m, 2H), 1.40 (s, 9H), 1.62-1.76 (m, 2H), 2.04-2.32 (m, 5H), 3.22-3.40 (m, 1H), 3.62-3.66 (m, 1H), 7.22-7.24 (m, 1H), 7.38-7.38 (m, 1H), 7.60 (s, 1H), 8.33-8.36 (m, 1H). 
     Ia-32 
     mp 260-261° C. 
       1 H-NMR (CDCl 3 /DMSO) δ ppm: 1.25-1.42 (m, 2H), 1.38 (s, 9H), 1.64 (q, 2H, J=13.5 Hz), 1.95 (d, 2H, J=12.3 Hz), 2.16 (d, 2H, J=10.5 Hz), 2.18-2.32 (m, 1H), 3.14-3.30 (m, 1H), 5.53 (d, 1H, J=9.0 Hz), 7.31 (d, 1H, J=8.7 Hz), 7.46 (dd, 1H, J=2.4, 8.7 Hz), 7.90 (d, 1H, J=2.1 Hz), 9.35 (s, 1H). 
     Ia-33 
     mp 227° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H) 1.30-1.56 (m, 4H), 1.78-2.01 (m, 2H), 2.12-2.36 (m, 2H), 2.96-3.13 (m, 1H), 3.70 (s, 3H), 3.71 (s, 3H), 6.77 (d, 1H, J=8.7 Hz), 6.85 (d, 1H, J =8.7 Hz), 7.06 (dd, 1H, J=2.4, 8.7 Hz), 7.33 (d, 1H, J=2.4 Hz), 9.65 (s, 1H). 
     Ia-35 
     mp 214-216° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.23-1.38 (m, 2H), 1.40 (s, 9H), 1.60-1.76 (m, 2H), 2.00-2.12 (m, 2H), 2.20-2.32 (m, 3H), 3.24-3.39 (m, 1H), 3.68 (d, 1H, J=9.0 Hz), 6.77 (d, 1H, J=8.7 Hz), 7.00 (dd, 1H, J=2.4, 8.7 Hz), 7.77 (s, 1H), 8.45 (d, 1H, J=2.4 Hz). 
     Ia-36 
     mp 241-242° C. 
       1 H-NMR (CDCl 3 /DMSO) δ ppm: 1.25-1.42 (m, 2H), 1.37 (s, 9H), 1.62 (q, 2H, J=11.7 Hz), 1.93 (d, 2H, J=12.0 Hz), 2.12 (d, 2H, J=10.8 Hz), 2.16-2.30 (m, 1H), 3.12-3.28 (m, 1H), 3.84 (s, 3H), 6.07 (d, 1H, J=8.4 Hz), 6.89 (dd, 1H, JFH, HH=9.3, 9.3 Hz), 7.24 (d, 1H, J=8.7 Hz), 7.55 (d, 1H, JFH=13.5 Hz), 9.32 (s, 1H). 
     Ia-37 
     mp 248-249° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.60-0.73 (m, 1H), 0.91 (d, 6H, J=6.6), 1.12-1.40 (m, 2H), 1.40 (s, 9H), 1.54-1.88 (m, 5H), 1.98-2.29 (m, 7H), 3.22-3.37 (m, 1H), 3.51-3.54 (m, 2H), 3.72 (d, 1H, J=9.6), 6.88 (d, 1H, J=8.7), 7.06 (s, 1H), 7.35 (d, 1H, J=9.0). 
     Ia-38 
     mp 237-238° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.01 (d, 6H, J=6.6), 1.20-1.40 (m, 2H), 1.40 (s, 9H), 1.60-1.74 (m, 4H), 1.99-2.28 (m, 7H), 2.69-2.82 (m, 2H), 3.02-3.14 (m, 2H), 3.20-3.38 (m, 1H), 3.80-3.90 (m, 1H), 6.83-6.86 (m, 2H), 7.14 (s, 1H), 7.34 (d, 1H, J=8.4). 
     Ia-39 
     mp 234-235° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.36 (m, 2H), 1.40 (s, 9H), 1.60-1.77 (m, 2H), 1.90-2.32 (m, 5M), 3.21-3.39 (m, 1H), 3.65 (d, 1H, J=9.6 Hz), 6.87 (d, 1H, J=8.7 Hz), 7.04 (s, 1H), 7.37 (dd, 1H, J=2.7, 8.7 Hz), 7.56 (d, 1H, J=2.7 Hz). 
     Ia-40 
     mp 257-258° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.14 (d, 6H, J=6.0 Hz), 1.27 (s, 9H), 1.28-1.53 (m, 4H), 1.78-2.00 (m, 4H), 2.13-2.256 (m, 1H), 2.30 (t, 2H, J=11.7 Hz), 2.97-3.12 (m, 1H), 3.53-3.67 (m, 2H), 4.01 (d, 1H, J=12.3 Hz), 6.80 (dd, 1H, J=3.0, 9.0 Hz), 7.79 (d, 1H, J=9.0 Hz), 8.27 (s, 1H), 9.66 (s, 1H). 
     Ia-41 
     mp 245-246° C. 
       1 H-NMR (CDCl 3 /DMSO) δ ppm: 1.25-1.42 (m, 2H), 1.37 (s, 9H), 1.62 (q, 2H, J=12.6 Hz), 1.94 (d, 2H, J=11.1 Hz), 2.13 (d, 2H, J=11.1 Hz), 2.18-2.35 (m, 1H), 3.11-3.29 (m, 1H), 6.07 (d, 1H, J=8.1 Hz), 6.95-7.06 (m, 1H), 7.14-7.27 (m, 1H), 7.44 (d, 1H, J=7.2 Hz), 7.79 (s, 1H), 9.48 (s, 1H). 
     Ia-43 
     mp 294-295° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.26 (s, 9H), 1.28-1.53 (m, 4H), 1.76-1.87 (m, 2H), 1.89-2.00 (m, 2H), 2.13-2.25 (m, 1H), 2.96-3.10 (m, 5H), 3.52-3.60 (m, 4H), 6.78 (d, 1H, J=9.0 Hz), 6.88 (d, 2H, J=9.0 Hz), 7.44 (d, 2H, J=9.0 Hz), 9.59 (s, 1H). 
     Ia-44 
     mp 250-252° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.13 (d, 6H, J=6.3 Hz), 1.21-1.38 (m, 2H), 1.41 (s, 9H), 1.63-1.80 (m, 2H), 1.93 (t, 2H, J=10.8 Hz), 2.00-2.10 (m, 2H), 2.16-2.32 (m, 3H) 3.24-3.39 (m, 1H), 3.54 (d, 2H, J=10.2 Hz), 3.64-3.78 (m, 3H), 7.47 (s, 1H), 7.69 (d, 2H, J=9.0 Hz), 7.73 (d, 2H, J=9.0 Hz). 
     Ia-45 
     mp 193° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.10 (t, 6H, J=7.2 Hz), 1.26 (s, 9H), 1.28-1.52 (m, 4H), 1.75-1.86 (m, 2H), 1.89-2.01 (m, 2H), 2.10-2.22 (m, 1H), 2.96-3.10 (m, 1H), 3.30-3.52 (m, 12H), 6.60 (d, 2H, J=9.0 Hz), 6.80 (d, 1H, J=9.0 Hz), 7.33 (d, 2H, J=9.0 Hz), 9.46 (s, 1H). 
     Ia-46 
     mp &gt;300° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.28 (s, 9H), 1.28-1.58 (m, 4H), 1.83-2.04 (m, 4H), 2.23-2.36 (m, 1H), 2.46 (s, 3H), 3.00-3.14 (m, 1H), 6.79 (d, 1H, J=8.7 Hz), 7.34 (d, 1H, J=8.7 Hz), 7.78 (d, 2H, J=8.7 Hz), 7.89 (d, 1H, J=8.4 Hz), 7.91 (s, 1H), 8.00 (d, 2H, J=8.7 Hz), 10.13 (s, 1H). 
     Ia-47 
     mp 236-237° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.97 (d, 6H, J=6.6 Hz), 1.01 (d, 6H, J=6.6 Hz), 1.20-1.37 (m, 2H), 1.40 (s, 9H), 1.60-1.84 (m, 3H), 1.97-2.31 (m, 5H), 2.50 (t, 1H, J=10.8 Hz), 2.78 (dt, 1H, J=3.3, 11.4 Hz), 3.25-3.38 (m, 1H), 3.45 (d, 1H, J=11.4 Hz), 3.75 (dt, 1H, J=2.4, 11.4 Hz), 4.02 (dt, 1H, J=2.4, 11.4 Hz), 6.88 (d, 2H, J=9.0 Hz), 7.05 (s, 1H), 7.39 (d, 2H, J=9.0 Hz). 
     Ia-48 
     mp 228-229° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.88 (t, 6H, J=7.2 Hz), 1.19-1.45 (m, 4H), 1.40 (s, 9H), 1.45-1.76 (m, 4H), 1.76-1.92 (m, 1H), 1.96-2.30 (m, 5H), 2.66-3.20 (m, 3H), 3.20-3.40 (m, 1H), 3.78 (d, 1H, J=9.3 Hz), 3.82 (s, 1H), 6.62-6.98 (m, 2H), 7.09 (brs, 1H), 7.37 (d, 2H, J=7.8 Hz). 
     Ia-49 
     mp 262-263° C. 
       1 H-NMR (CDCl 3 /DMSO) δ ppm: 1.21 (d, 6H, J=5.7 Hz), 1.26-1.34 (m, 2H), 1.37 (d, 6H, J=5.4 Hz), 1.52-1.76 (m, 2H), 1.85-2.03 (m, 2H), 2.03-2.30 (m, 3H), 2.30-2.53 (m, 2H), 3.02-3.33 (m, 4H), 3.75-3.98 (m, 2H), 5.70 (brs, 1H), 6.73-6.98 (m, 1H), 7.14-7.25 (m, 1H), 7.52 (d, 1H, JFH=13.5 Hz), 8.86 (brs, 1H). 
     Ia-50 
     mp 232-233° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.21 (d, 6H, J=6.3 Hz), 1.22-1.37 (m, 2H), 1.38 (d, 6H, J=6.9 Hz), 1.68 (q, 2H, J=12.6 Hz), 1.98-2.26 (m, 5H), 2.29 (s, 3H), 2.41 (t, 2H, J=10.2 Hz), 2.88 (d, 2H, J=11.1 Hz), 3.15 (septet, 1H, J=6.6 Hz), 3.21-3.37 (m, 1H), 3.77-3.92 (m, 2H), 3.87 (d, 1H, J=7.8 Hz), 6.88-7.06 (m, 3H), 7.35 (s, 1H). 
     Ia-51 
     mp 211-212° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.20-1.42 (m, 2H), 1.26 (d, 6H, J=6.3 Hz), 1.38 (d, 6H, J=6.9 Hz), 1.62-1.78 (m, 2H), 1.99-2.28 (m, 5H), 2.49 (dd, 2H, J=10.5, 10.5 Hz), 3.17 (quint, 1H, J=6.9 Hz), 3.20-3.38 (m, 1H), 3.66-3.99 (m, 2H), 3.90-4.01 (m, 3H), 6.62 (d, 1H, J=9.0 Hz), 7.06 (s, 1H), 7.90 (dd, 1H, J=2.4, 9.0 Hz), 8.09 (d, 1H, J=2.4 Hz). 
     Ia-52 
     mp 247-249° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.21-1.36 (m, 2H), 1.40 (s, 9H) 1.62-1.78 (m, 2H), 1.98-2.32 (m, 5H), 2.55 (t, 4H, J=6.0 Hz), 3.23-3.38 (m, 1H), 3.55 (t, 4H, J=6.0 Hz), 3.72 (d, 1H, J=9.6 Hz), 6.94 (d, 2H, J=9.0 Hz), 7.10 (s, 1H), 7.42 (d, 1H, J=9.0 Hz). 
     Ia-53 
     mp 234-235° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22-1.38 (m, 2H), 1.41 (s, 9H) 1.84-1.80 (m, 2H), 2.00-2.32 (m, 5H), 3.25-3.40 (m, 1H), 3.73 (d, 1H, J=9.3 Hz), 7.43 (s, 1H), 7.48 (t, 2H, J=7.5 Hz), 7.55-7.66 (m, 3H), 7.68-7.89 (m, 4H). 
     Ia-54 
     mp 235-236° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.24-1.39 (m, 2H), 1.25 (d, 6H, J=6.3 Hz), 1.39 (d, 6H, J=6.9 Hz), 1.60-1.80 (m, 2H), 2.00-2.28 (m, 5H), 2.21 (s, 3H), 2.38 (t, 2H, J=10.8 Hz), 3.15 (septet, 1H, J=6.3 Hz), 3.23-3.38 (m, 1H), 3.40 (d, 2H, J=11.7 Hz), 3.72-3.88 (m, 2H), 3.87 (d, 1H, J=9.3 Hz), 6.78-6.86 (m, 3H), 7.50 (d, 1H, J=9.6 Hz). 
     Ia-55 
     mp 185-186° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.14 (d, 6H, J=6.3 Hz), 1.22-1.38 (m, 2H), 1.41 (s, 9H), 1.62-1.78 (m, 2H), 2.02 (t, 2H, J=10.5 Hz), 2.02-2.10 (m, 2H), 2.16-2.31 (m, 3H), 3.24-3.39 (m, 1H), 3.56 (d, 2H, J=9.3 Hz), 3.63-3.80 (m, 3H), 7.46 (dd, 1H, J=1.5, 8.1 Hz), 7.51 (t, 1H, J=8.1 Hz), 7.63 (s, 1H), 7.81 (t, 1H, J=1.8 Hz), 7.98 (dt, 1H, J=1.8, 8.1 Hz). 
     Ia-56 
     mp 229-230° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.28-1.54 (m, 4H), 1.38 (s, 6H), 1.78-1.84 (m, 2H), 1.90-2.00 (m, 2H), 2.15-2.30 (m, 1H), 2.97-3.13 (m, 1H), 4.90 (s, 1H), 6.79 (d, 1H, J=9.0 Hz), 7.34 (d, 2H, J=8.7 Hz), 7.48 (d, 2H, J=8.4 Hz), 9.72 (s, 1H). 
     Ia-57 
     mp 211-212° C. 
       1 H-NMR (CDCl 3 /DMSO) δ ppm: 1.24-1.40 (m, 2H), 1.38 (s, 9H), 1.57-1.74 (m, 2H), 1.91 (s, 3H), 1.92-2.01 (m, 2H), 2.12-2.24 (m, 2H), 2.51 (brs, 1H), 3.18-3.33 (m, 1H), 4.96 (d, 1H, J=9.3 Hz), 7.16-7.53 (m, 9 Hz) 7.41 (s, 1H). 
     Ia-58 
     mp 298-299° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.24 (s, 9H), 1.27 (s, 9H), 1.28-1.54 (m, 4H), 1.75-2.02 (m, 4H), 2.14-2.28 (m, 1H), 2.97-3.11 (m, 1H), 6.78 (d, 1H, J=8.4 Hz), 7.18 (d, 2H, J=9.0 Hz), 7.48 (d, 2H, J=9.0 Hz), 9.46 (s, 1H), 9.76 (s, 1H). 
     Ia-59 
     mp 253-254° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22-1.40 (m, 2H), 1.41 (s, 9H), 1.65-1.81 (m, 2H), 2.04-2.16 (m, 2H), 2.22-2.36 (m, 2H), 3.24-3.41 (m, 1H), 3.74 (d, 1H, J=9.6 Hz), 7.40-7.54 (m, 3H), 7.88-8.01 (m, 3H), 8.66 (d, 1H, J=1.5 Hz), 9.57 (d, 1H, J=1.2 Hz). 
     Ia-60 
     mp 213-214° C. 
       1 H-NMR (DMSO) δ ppm: 1.32-1.50 (m, 2H), 1.35 (s, 1.52-1.70 (m, 2H), 1.88-2.00 (m, 2H), 2.04-2.16 (m, 2H), 2.22-2.38 (m, 1H) 2.65 (s, 3H), 2.99-3.15 (m, 1H), 6.46 (d, 1H, J=9.3 Hz), 7.28 (d, 1H, J=9.0 Hz), 7.81 (s, 1H), 8.20 (s, 1H), 8.47 (s, 1H), 9.89 (s, 1H). 
     Ia-61 
     mp 274-275° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 1H), 1.28-1.58 (m, 4H), 1.84-2.08 (m, 4H), 2.22-2.40 (m, 1H), 2.99-3.15 (m, 1H), 3.01 (s, 3H), 6.81 (d, 1H, J=8.1 Hz), 7.78 (d, 2H, J=7.8 Hz), 7.84 (d, 2H, J=8.4 Hz), 8.18 (s, 1H), 10.43 (s, 1H). 
     Ia-62 
     mp 235-236° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22-1.39 (m, 2H), 1.41 (s, 3H), 1.66-1.80 (m, 2H), 2.01-2.12 (m, 2H), 2.14-2.22 (m, 1H), 2.23-2.34 (m, 2H), 3.24-3.42 (m, 1H), 3.69 (d, 1H, J=9.5 Hz), 6.44 (d, 1H, J=9.3 Hz), 7.27 (brs, 1H), 7.28 (d, 1H, J=9.3 Hz), 7.37 (dd, 1H, J=2.4, 9.0 Hz), 7.68 (d, 1H, J=9.6 Hz), 8.04 (d, 1H, J=2.4 Hz). 
     Ia-63 
     mp 277-279° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.28-1.54 (m, 4H), 1.77-2.02 (m, 4H), 2.15-2.29 (m, 1H), 2.90 (s, 3H), 2.96-3.13 (m, 1H), 6.79 (d, 1H, J=8.7 Hz), 7.12 (d, 2H, J=9.0 Hz), 7.54 (d, 2H, J=9.0 Hz), 9.50 (s, 1H), 9.81 (s, 1H). 
     Ia-64 
     mp 259-260° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.26 (s, 9H), 1.26-1.50 (m, 4H), 1.74-1.99 (m, 4H), 2.10-2.25 (m, 1H), 2.95-3.10 (m, 1H), 6.78 (d, 1H, J=8.7 Hz), 6.97 (d, 2H, J=9.0 Hz), 7.42 (d, J =9.0 Hz), 7.50-7.71 (m, 5H), 9.73 (s, 1H), 10.05 (s, 1H). 
     Ia-65 
     mp 292-293° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.28-1.54 (m, 4H), 1.62-1.72 (m, 2H), 1.77-1.87 (m, 2H), 1.91-2.10 (m, 4H), 2.13-2.25 (m, 1H), 2.98-3.12 (m, 1H), 3.41-3.52 (m, 2H), 5.09 (s, 1H), 6.79 (d, 1H, J=9.0 Hz), 6.91 (d, 2H, J=9.0 Hz), 7.37 (d, 2H, J=9.0 Hz), 7.42 (d, 2H, J =9.0 Hz), 7.51 (d, 2H, J=9.0 Hz), 9.56 (s, 1H). 
     Ia-66 
     mp &gt;300° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.28-1.58 (m, 4H), 1.85-2.02 (m, 4H), 2.40-2.52 (m, 1H), 3.00-3.16 (m, 1H), 6.81 (d, 1H, J=9.0 Hz), 7.50-7.58 (m, 3H), 7.90-7.97 (m, 2H), 12.58 (s, 1H). 
     Ia-67 
     mp 199-200° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.14 (d, 6H, J=6.3 Hz), 1.28 (s, 9H), 1.31-1.48 (m, 4H), 1.76-1.88 (m, 2H), 2.17 (t, 2H, J=11.1 Hz), 2.82 (t, 2H, J=11.7 Hz), 3.46 (d, 2H, J=11.4 Hz), 3.20-3.36 (m, 1H), 3.62-3.74 (m, 2H), 4.02 (d, 2H, J=12.9 Hz), 6.83 (d, 2H, J=9.0 Hz), 6.89 (d, 1H, J=8.7 Hz), 7.28 (d, 2H, J=9.0 Hz), 8.27 (s, 1H). 
     Ia-68 
     mp 237-239° C. 
       1 H-NMR (CDCl 3 /DMSO) δ ppm: 1.40 (s, 9H), 1.49-1.65 (m, 2H), 1.99-2.10 (m, 2H), 2.95 (t, 2H, J=11.1 Hz), 3.36-3.52 (m, 1H), 4.17 (d, 1H, J=12.9 Hz), 5.84 (d, 1H, J=8.7 Hz), 6.39 (d, 1H, J=9.6 Hz), 7.21 (d, 1H, J=9.3 Hz), 7.51 (dd, 1H, J=2.4, 9.3 Hz), 7.72 (d, 1H, J=9.9 Hz), 7.85 (d, 1H, J=2.7 Hz), 8.04 (s, 1H). 
     Ia-69 
     mp 259-260° C. 
       1 H-NMR (DMSO) δ ppm: 1.25-1.55 (m, 4H), 1.27 (s, 9H), 1.82-2.05 (m, 4H), 2.22-2.36 (m, 1H), 2.98-3.17 (m, 1H), 4.16 (s, 3H), 6.80 (d, 1H, J=8.4 Hz), 7.77-7.87 (m, 4H), 10.16 (s, 1H). 
     Ia-70 
     mp 259-260° C. 
       1 H-NMR (DMSO) δ ppm: 1.28 (s, 9H), 1.36-1.56 (m, 2H), 1.30-1.92 (m, 2H), 2.86-3.02 (m, 2H), 3.36-3.52 (m, 1H), 4.04-4.20 (m, 2H), 6.92 (d, 1H, J=7.5 Hz), 7.38-7.58 (m, 3H), 8.00-8.14 (m, 2H), 8.90 (s, 1H), 9.08 (s, 1H), 9.63 (s, 1H). 
     Ia-71 
     mp 228-229° C. 
       1 H-NMR (CDCl 3 /DMSO) δ ppm: 1.27-1.42 (m, 2H), 1.38 (s, 9H), 1.57-1.75 (m, 2H), 1.90-2.02 (m, 2H), 2.12-2.34 (m, 3H), 3.14-3.32 (m, 1H), 5.37 (d, 1H, J=9.3 Hz), 7.38-7.43 (m, 3H), 7.46 (d, 2H, J=8.7 Hz), 7.51-7.60 (m, 2H), 7.68 (d, 2H, J=9.0 Hz), 9.33 (s, 1H). 
     Ia-75 
     mp 169-170° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.58-0.72 (m, 1H), 0.80 (d, 3H, J=6.6 Hz), 0.94 (d, 3H, J=6.0 Hz), 1.14-1.35 (m, 3H), 1.39 (s, 9H), 1.48-1.66 (m, 2H), 1.74-2.06 (m, 5H), 2.06-2.44 (m, 6H), 3.18-3.35 (m, 1H), 3.64-3.74 (m, 1H), 4.46-4.60 (m, 1H), 6.98-7.38 (m, 5H). 
     Ia-76 
     mp 236-237° C. 
       1 H-NMR (CDCl 3 /DMSO) δ ppm: 1.27-1.42 (m, 2H), 1.38 (d, 6H, J=6.6 Hz), 1.60-1.78 (m, 2H), 1.94-2.06 (m, 2H), 2.12-2.30 (m, 3H), 3.06-3.34 (m, 2H), 5.10 (brs, 1H), 6.41 (d, 1H, J =9.9 Hz), 7.25 (d, 1H, J=8.4 Hz), 7.48 (dd, 1H, J=2.4, 8.7 Hz), 7.68 (d, 1H, J=9.9 Hz), 8.12 (d, 1H, J=2.4 Hz), 8.88 (brs, 1H). 
     Ia-77 
     mp 117-118° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.38 (d, 6H, J=6.9 Hz), 1.65 (quintet, 2H, J=5.4 Hz), 1.75-1.91 (m, 2H), 2.42 (t, 2H, J=7.4 Hz), 3.10-3.24 (m, 3H), 4.77 (brs, 1H), 6.41 (d, 1H, J=9.6Hz), 7.18-7.26 (m, 1H), 7.48 (dd, 1H, J=1.8, 8.7 Hz), 7.67 (d, 1H, J=9.9 Hz), 8.01 (s, 1H), 8.23 (brs, 1H). 
     Ia-78 
     mp 138-139° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.41 (s, 9H), 1.64 (quintet, 2H, J=6.6 Hz), 1.84 (quintet, 2H, J=7.3 Hz), 2.42 (t, 2H, J=7.5 Hz), 3.26 (q, 2H, J=6.5 Hz), 4.59 (brs, 1H), 6.41 (d, 1H, J=9.3 Hz), 7.23 (d, 1H, J=8.7 Hz), 7.49 (dd, 1H, J=2.4, 9.0 Hz), 7.67 (d, 1H, J=9.9 Hz), 8.03 (d, 1H, J=2.4 Hz), 8.28 (brs, 1H). 
     Ia-79 
     mp 289-290° C. 
       1 H-NMR (DMSO) δ ppm: 1.24-1.63 (m, 4H), 1.28 (s, 9H), 1.84-2.08 (m, 4H), 2.24-2.41 (m, 1H), 3.00-3.16 (m, 1H), 6.82 (d, 1H, J=8.1 Hz), 7.36-7.60 (m, 5H), 7.86-7.99 (m, 2H), 8.28 (s, 1H), 10.50 (s, 1H). 
     Ia-80 
     mp 239-240° C. 
       1 H-NMR (DMSO) δ ppm: 1.22 (d, 1H, J=6.6 Hz), 1.23-1.40 (m, 2H), 1.40-1.59 (m, 2H), 1.83-2.04 (m, 4H), 2.23-2.39 (m, 1H), 2.98-3.23 (m, 2H), 7.00 (d, 1H, J=7.8 Hz), 7.36-7.59 (m, 5H) 7.85-7.97 (m, 2H), 8.29 (s, 1H), 10.50 (s, 1H). 
     Ia-81 
     mp 205-206° C. 
       1 H-NMR (CDCl 3 /DMSO) δ ppm: 1.40 (s, 9H), 1.66 (quintet, 2H, J=7.0 Hz), 1.85 (quintet, 2H, J=7.2 Hz), 2.45 (t, 2H, J=7.5 Hz), 3.24 (t, J=6.5 Hz), 5.17 (brs, 1H), 7.36-7.54 (m, 5H), 7.85 (d, 1H, J=8.4 Hz), 8.07 (dd, 1H, J=1.8, 8.1 Hz), 8.23 (d, 1H, J=1.8 Hz), 9.61 (s, 1H). 
     Ia-82 
     mp 216-217° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.14 (d, 6H, J=6.3 Hz), 1.22 (d, 6H, J=6.9 Hz), 1.22-1.53 (m, 4H), 1.76-1.98 (m, 2H), 2.21 (t, 2H, J=10.8 Hz), 2.22-2.36 (m, 1H), 2.96-3.20 (m, 2H), 3.57 (d, 2H, J=12.0 Hz), 3.60-3.74 (m, 1H), 6.66-6.85 (m, 2H), 6.98 (d, 1H, J=7.8 Hz), 7.47 (d, 1H, J=8.7 Hz), 9.30 (s, 1H). 
     Ia-83 
     mp 118-119° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.41 (d, 6H, J=6.3 Hz), 1.26 (s, 9H), 1.40-1.67 (m, 4H), 2.17-2.36 (m, 3H), 2.97-3.10 (m, 2H), 3.57 (d, 2H, J=12.0 Hz), 3.61-3.74 (m, 1H), 6.67-6.92 (m, 3H), 7.48 (t, 1H, J=9.0 Hz), 9.37 (s, 1H). 
     Ia-84 
     mp 265-267° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.21 (d, 6H, J=6.6 Hz), 1.20-1.57 (m, 4H), 1.60-2.30 (m, 9H), 2.99-3.20 (m, 4H), 3.40-3.52 (m, 2H), 5.09 (s, 1H), 6.91 (d, 2H, J=8.7 Hz), 6.98 (d, 1H, J=7.5 Hz), 7.37 (d, 2H, J=8.7 Hz), 7.42 (d, 2H, J=8.7 Hz), 7.51 (d, 2H, J=8.7 Hz), 9.56 (s, 1H). 
     Ia-85 
     mp 185-186° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.26 (s, 9H), 1.42-1.72 (m, 6H), 1.96-2.10 (m, 2H), 2.26 (t, 2H, J=6.9 Hz), 2.96-3.12 (m, 4H), 3.41-3.52 (m, 2H), 5.09 (s, 1H), 6.88 (d, J=8.7 Hz), 6.92 (d, 2H, J=9.0 Hz), 7.37 (d, 2H, J=8.7 Hz), 7.43 (d, 2H, J=9.0 Hz), 7.52 (d, 2H, J=8.7 Hz), 9.63 (s, 1H). 
     Ia-86 
     mp 162-164° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.21 (d, 6H, J=6.6 Hz), 1.41-1.73 (m, 6H), 1.96-2.10 (m, 2H), 2.26 (t, 2H, J=7.2 Hz), 2.91-3.20 (m, 5H), 3.42-3.52 (m, 2H), 5.09 (s, 1H), 6.92 (d, 2H, J=9.3 Hz), 6.99 (t, 1H, J=6.0 Hz), 7.37 (d, 2H, J=8.7 Hz), 7.43 (d, 2H, J=9.3 Hz), 7.52 (d, 2H, J=8.7 Hz), 9.64 (s, 1H). 
     Ia-87 
     mp 245-247° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.22 (d, 6H, J=6.6 Hz), 1.22-1.58 (m, 4H), 1.81-2.02 (m, 4H), 2.22-2.36 (m, 1H), 3.00-3.20 (m, 2H), 3.01 (s, 3H), 6.99 (d, 1H, J=8.4 Hz), 7.75-7.88 (m, 2H), 8.19 (d, 1H, J=1.2 Hz), 10.43 (s, 1H). 
     Ia-88 
     mp 208-209° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.22 (d, 6H, J=6.9 Hz), 1.22-1.55 (m, 4H), 1.75-1.98 (m, 4H), 2.11-2.24 (m, 1H), 2.98-3.20 (m, 2H), 5.96 (s, 2H), 6.82 (d, 1H, J=8.4 Hz), 6.91-7.03 (m, 2H), 7.30 (d, 1H, J=1.8 Hz), 9.72 (s, 1H). 
     Ia-89 
     mp 142-143° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.40-1.66 (m, 4H), 2.26 (t, 2H, J=7.5 Hz), 3.02 (q, 2H, J=6.6 Hz), 5.96 (s, 2H), 6.82 (d, 1H, J=8.4 Hz), 6.88 (t, 1H, J=8.4 Hz), 6.94 (dd, 1H, J=1.8, 8.4 Hz), 7.30 (d, 1H, J=1.8 Hz), 9.78 (s, 1H). 
     Ia-90 
     mp 100° C. 
       1 H-NMR, (DMSO-d 6 ) δ ppm: 1.20 (d, 6H, J=6.9 Hz), 1.40-1.66 (m, 4H), 2.26 (t, 2H, J=7.5 Hz), 2.89-2.99 (m, 2H), 3.13 (quint, 1H, J=6.6 Hz), 5.96 (s, 2H), 6.83 (d, 1H, J=8.1 Hz), 6.91-7.02 (m, 2H), 7.30 (d, 1H, J=1.8 Hz), 9.78 (s, 1H). 
     Ia-91 
     mp 189-190° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.26 (s, 9H), 1.43-1.71 (m, 4H), 2.40 (t, 2H, J=7.5 Hz), 2.97-3.09 (m, 2H), 3.01 (s, 3H), 6.85-6.93 (m, 1H), 7.76-7.88 (m, 2H), 8.20 (d, 1H, J=1.2 Hz), 10.49 (s, 1H). 
     Ia-104 
     mp 238-241° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.3-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.50 (m, 1H), 3.05 (m, 1H), 6.55 (brs, 1H), 6.79 (d, 1H, J=8.2), 7.15 (t, 1H, J=4.8), 8.64 (d, 2H, J=4.8). 
     Ia-105 
     mp 232-234° C. 
       1 H-NMR (DMSO) δ ppm: 1.26 (s, 9H), 1.2-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.55 (m, 1H), 3.05 (m, 1H), 6.77 (d, 1H, J=8.7), 9.92 (s, 2H), 10.93 (s, 1H). 
     Ia-106 
     mp 226-228° C. 
       1 H-NMR (DMSO) δ ppm: 1.28 (s, 9H), 1.22-1.58 (m, 4H), 1.82-2.04 (m, 4H), 2.29 (m, 1H), 3.07 (m, 1H), 6.79 (d, 1H, J=8.7 Hz), 7.61 (d-d, 1H, J=1.8 Hz, 8.7 Hz), 8.04 (d, 1H, J=8.7 Hz), 8.48 (d, 1H, 2.1 Hz), 9.35 (s, 1H), 10.05 (s, 1H). 
     Ia-107 
     mp 282-283° C. 
       1 H-NMR (DMSO) δ ppm: 1.22-1.57 (m, 4H), 1.27 (s, 9H), 1.80-2.04 (m, 4H), 2.27 (m, 1H), 3.06 (m, 1H), 6.81 (d, 1H, J=8.7 Hz), 7.32 (m, 1H), 7.44 (t, 2H, J=7.5 Hz), 7.57-7.72 (m, 6H), 9.91 (s, 1H). 
     Ia-108 
     mp 191-192° C. 
       1 H-NMR (DMSO) δ ppm: 1.24-1.58 (m, 4H), 1.28 (s, 9H), 1.86-2.04 (m, 4H), 2.70 (m, 1H), 3.08 (m, 1H), 6.83 (d, 1H, J=8.7 Hz), 7.63-7.79 (m, 2H), 8.31 (d, 1H, J=7.2 Hz), 10.27 (s, 1H). 
     Ia-109 
     mp 283-285° C. 
       1 H-NMR (DMSO) δ ppm: 1.24-1.60 (m, 4H), 1.28 (s, 9H), 1.87-2.04 (m, 4H), 2.42 (m, 1H), 3.09 (m, 1H), 3.87 (s, 2H), 6.82 (d, 1H, J=8.7 Hz), 7.28-7.43 (m, 3H), 7.60 (d, 2H, J=7.8 Hz), 7.68 (d, 1H, J=7.2 Hz), 7.89 (d, 1H, J=7.5 Hz), 9.48 (s, 1H). 
     Ia-110 
     mp 263-265° C. 
       1 H-NMR (DMSO) δ ppm: 1.24-1.54 (m, 4H), 1.27 (s, 9H), 1.76-1.87 (m, 2H), 1.89-2.01 (m, 2H), 2.17 (m, 1H), 3.04 (m, 1H), 4.01 (s, 4H), 6.01 (s, 2H), 6.44 (d, 2H, J=8.7 Hz), 6.77 (d, 1H, J=8.7 Hz), 7.39 (d, 2H, J=9.0 Hz), 9.44 (s, 1H). 
     Ia-111 
     mp 239-241° C. 
       1 H-NMR (DMSO) δ ppm: 1.24-1.54 (m, 4H), 1.27 (s, 9H), 1.62-1.76 (m, 4H), 1.80-2.02 (m, 4H), 2.30 (m, 1H), 2.47-2.59 (m, 2H), 2.66-2.76 (m, 2H), 6.08 (m, 1H), 6.79 (d, 1H, J=9.0 Hz), 6.88 (d, 1H, J=6.9 Hz), 7.02 (t, 1H, J=7.5 Hz), 7.13 (d, 1H, J=7.5 Hz), 8.98 (s, 1H). 
     Ia-124 
     mp 247-249° C. 
       1 H-NMR (DMSO) δ ppm: 1.15 (d, 6H, J=6.3 Hz), 1.30 (s, 9H), 2.15-2.26 (m, 2H), 3.48-3.57 (m, 2H), 3.63-3.76 (m, 2H), 6.92 (d, 2H, J=8.7 Hz), 7.59 (d, 2H, J=9.0 Hz), 7.38 (d, 2H, J=9.0 Hz), 7.87 (d, 2H, J=8.7 Hz), 9.92 (brs, 1H), 9.98 (brs, 1H). 
     Ia-125 
     mp 228-232° C. 
       1 H-NMR (DMSO) δ ppm: 1.30 (s, 9H), 1.95-2.08 (m, 2H), 2.77-2.89 (m, 4H), 7.17 (d, 1H, J=8.4 Hz), 7.39 (d, 2H, J=9.0 Hz), 7.42-7.48 (m, 1H), 7.64 (brs, 1H), 7.87 (d, 2H, J=9.0 Hz), 9.99 (brs, 2H). 
     Ia-126 
     mp 244-246° C. 
       1 H-NMR (DMSO) δ ppm: 1.31 (s, 9H), 7.42 (d, 2H, J=8.4 Hz), 7.81 (d-d, 1H, J=2.1 Hz, 8.7 Hz), 7.93 (d, 2H, J=9.0 Hz), 8.05 (d, 1H, J=9.0 Hz), 8.66 (d, 1H, J=2.1 Hz), 9.29 (s, 1H), 10.05 (brs, 1H), 10.39 (brs, 1H). 
     Ia-127 
     mp 238-239° C. 
       1 H-NMR (DMSO) δ ppm: 1.30 (s, 9H), 4.18-4.27 (m, 4H), 6.81 (d, 1H, J=8.4 Hz), 7.16 (d-d, 1H, J=2.7 Hz, 9.0 Hz), 7.34-7.42 (m, 3H), 7.85 (d, 2H, J=8.4 Hz), 9.94 (brs, 1H), 9.99 (brs, 1H). 
     Ia-128 
     mp 286-287° C. 
       1 H-NMR (DMSO) δ ppm: 1.31 (s, 9H), 7.41 (d, 2H, J=8.7 Hz), 7.71 (d, 2H, J=8.4 Hz), 7.91 (d, 2H, J=8.7 Hz), 7.99 (d, 2H, J=8.7 Hz), 10.05 (brs, 1H), 10.44 (brs, 1H). 
     Ia-129 
     mp 232-234° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.3-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.25 (1H, m), 3.07 (m, 1H), 6.80 (d, 1H, J=9.0), 7.37 (d, 1H, J=8.1), 7.53 (t, 1H, J=8.1), 7.75 (t, 1H, J=8.1), 8.12 (s, 1H), 10.16 (s, 1H). 
     Ia-130 
     mp 274-277° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.23-1.58 (m, 4H), 1.81-2.03 (m, 4H), 2.28 (m, 1H), 3.07 (m, 1H), 6.80 (d, 1H, J=8.4 Hz), 7.36 (d-d, 1H, J=0.9 Hz, 5.7 Hz), 7.43 (d-d, 1H, J=2.1 Hz, 8.7 Hz), 7.60 (d, 1H, J=5.4 Hz), 7.78 (d, 1H, J=8.7 Hz), 8.40 (d, 1H, 1.8 Hz), 9.97 (brs, 1H). 
     Ia-131 
     mp 259-260° C. 
       1 H-NMR (DMSO) δ ppm: 1.31 (s, 9H), 7.40 (d, 1H, J=4.8 Hz), 7.41 (d, 2H, J=8.7 Hz), 7.66 (d, 1H, J=5.1 Hz), 7.67 (d-d, 1H, J=1.8 Hz, 8.7 Hz), 7.84 (d, 1H, J=9.0 Hz), 7.92 (d, 2H, J=8.7 Hz), 8.50 (s, 1H), 10.03 (brs, 1H), 10.27 (brs 1H). 
     Ia-132 
     mp 265-266° C. 
       1 H-NMR (DMSO) δ ppm: 1.17 (d, 6H, J=6.6 Hz), 1.31 (s, 9H), 4.10 (m, 1H), 7.35-7.46 (m, 3H), 7.54 (d, 1H, J=7.5 Hz), 7.87-7.97 (m, 3H), 8.15 (brs, 1H), 8.20 (d, 1H, J=7.5 Hz), 10.03 (brs, 1H), 10.25 (brs, 1H). 
     Ia-133 
     mp 249-250° C. 
       1 H-NMR (DMSO) δ ppm: 1.31 (s, 9H), 7.41 (d, 2H, J=8.7 Hz), 7.45 (d, 1H, J=5.4 Hz), 7.67 (d-d, 1H, J=1.8 Hz, 8.7 Hz), 7.76 (d, 1H, J=5.4 Hz), 7.92 (d, 2H, J=8.7 Hz), 7.95 (d, 1H, J=8.1 Hz), 8.39 (d, 1H, J=1.8 Hz), 10.02 (brs, 1H), 10.23 (brs, 1H). 
     Ia-134 
     mp 305-306° C. 
       1 H-NMR (DMSO) δ ppm: 1.25 (m, 2H), 1.25 (s, 9H), 1.52 (m, 2H), 1.82 (m, 2H), 1.94 (m, 2H), 2.13 (m, 1H), 3.04 (m, 1H), 6.00 (d, 1H, J=8.1), 6.74 (d, 1H, J=8.4), 7.3-7.5 (m, 6H), 7.85 (d, 2H, J=7.5), 8.31 (d, 1H, J=8.4). 
     Ia-135 
     mp 220-222° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.3-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.37 (m, 1H), 3.03 (m, 1H), 6.80 (d, 1H, J=8.7), 7.04 (m, 1H), 7.29 (m, 1H), 7.79 (m, 1H), 9.60 (s, 1H). 
     Ia-136 
     mp 263-264° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.3-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.20 (m, 1H), 3.03 (m, 1H), 6.80 (d, 1H, J=8.4), 6.87 (m, 1H), 7.31 (m, 2H), 10.21 (s, 1H). 
     Ia-137 
     mp 260-262° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.3-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.30 (m, 1H), 3.05 (m, 1H), 6.80 (d, 1H, J=8.4), 7.13 (t, 2H, J=8.1), 7.31 (m, 1H), 9.52 (s, 1H). 
     Ia-138 
     mp 270-273° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.3-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.12 (m, 1H), 3.05 (m, 1H), 6.79 (d, 1H, J=9.0), 7.31 (m, 2H), 7.80 (m, 1H), 10.05 (s, 1H). 
     Ia-139 
     mp 267-270° C. 
       1 H-NMR (DMSO) δ ppm: 1.30 (s, 9H), 4.05 (s, 4H), 6.04 (s, 2H), 6.51 (d, 2H, J=8.7 Hz), 7.34 (d, 2H, J=8.4 Hz), 7.54 (d, 2H, J=8.4 Hz), 7.87 (d, 2H, J=8.4 Hz), 9.82 (brs, 1H), 9.97 (brs, 1H). 
     Ia-140 
     mp 227-229° C. 
       1 H-NMR (DMSO) δ ppm: 1.22 (d, 6H, J=6.6 Hz), 1.20-1.57 (m, 4H) 1.80-2.01 (m, 4H), 2.27 (m, 1H), 2.95-3.22 (m, 2H), 6.99 (d, 1H, J=7.8 Hz), 7.65 (d, 2H, J=8.7 Hz), 7.80 (d, 2H, J=8.4 Hz), 10.18 (brs, 1H). 
     Ia-141 
     mp 205-207° C. 
       1 H-NMR (DMSO) δ ppm: 1.22 (d, 6H, J=6.9 Hz), 1.20-1.55 (m, 4H), 1.75-2.05 (m, 6H), 2.21 (m, 1H), 2.72-2.85 (m, 4H), 2.93-3.20 (m, 2H), 6.98 (d, 1H, J=8.1 Hz), 7.10 (d, 1H, J=8.1 Hz), 7.26 (d-d, 1H, J=2.1 Hz, 8.1 Hz), 7.51 (s, 1H), 9.67 (brs, 1H). 
     Ia-142 
     mp 295-296° C. 
       1 H-NMR (DMSO) δ ppm: 1.15 (d, 6H, J=6.6), 1.27 (s, 9H), 1.3-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.27 (m, 1H), 3.05 (m, 1H), 4.07 (m, 1H), 6.80 (d, 1H, J=8.7), 7.64 (d, 2H, J=8.7), 7.79 (d, 2H, J=8.7), 8.06 (d, 1H, J=7.5), 10.01 (s, 1H). 
     Ia-143 
     mp 146-147° C. 
       1 H-NMR (DMSO) δ ppm: 1.26 (s, 9H), 1.5-1.7 (m, 4H), 2.36 (t, 2H, J=7.8), 3.03 (q, 2H, J=6.3), 6.89 (t, 1H, J=6.3), 7.66 (d, 2H, J=8.4), 7.80 (d, 2H, J=8.4), 10.25 (s, 1H). 
     Ia-144 
     mp 138-140° C. 
       1 H-NMR, (DMSO) δ ppm: 1.21 (d, 6H, J=6.0), 1.4-1.7 (m, 4H), 2.37 (t, 2H, J=7.5), 2.96 (q, 2H, J=6.3), 3.14 (m, 1H), 6.99 (t, 1H, J=5.4), 7.66 (d, 2H, J=7.8), 7.81 (d, 2H, J=7.8), 10.26 (s, 1H). 
     Ia-146 
     mp 134-136° C. 
       1 H-NMR (DMSO) δ ppm: 1.26 (s, 9H), 1.39 (m, 2H), 1.4-1.7 (m, 4H), 2.28 (t, 2H, J=7.2), 2.79 (m, 4H), 3.02 (q, 2H, J=7.2), 6.88 (t, 1H, J=6.0), 7.10 (t, 1H, J=6.0), 7.51 (s, 1H), 9.73 (s, 1H). 
     Ia-146 
     mp 135-137° C. 
       1 H-NMR (DMSO) δ ppm: 1.20 (d, 6H, J=6.6), 1.4-1.7 (m, 4H), 1.99 (m, 2H), 2.28 (t, 2H, J=7.2), 2.79 (m, 4H), 2.94 (q, 2H, J=6.3), 3.13 (m, 1H), 6.98 (t, 1H, J=6.9), 7.10 (d, 2H, J=8.1), 7.26 (d, 2H, J=8.1), 7.51 (s, 1H), 9.73 (s, 1H). 
     Ia-147 
     mp 206-207° C. 
       1 H-NMR (DMSO) δ ppm: 1.29 (s, 9H), 4.54 (d, 2H, J=5.7 Hz), 7.35 (d, 2H, J=9.0 Hz), 7.52 (d, 2H, J=7.8 Hz), 7.69 (d, 2H, J=8.1 Hz), 7.83 (d, 2H, J=8.7 Hz), 9.02 (t, 1H, J=5.7 Hz), 9.97 (brs, 1H). 
     Ia-148 
     mp 250-251° C. 
       1 H-NMR (DMSO) δ ppm: 1.30 (s, 9H), 7.18 (t, 2H, J=9.3 Hz), 7.40 (d, 2H, J=8.7 Hz), 7.76 (d-d, 2H, J=5.1 Hz, 9.3 Hz), 7.88 (d, 2H, J=9.0 Hz), 10.02 (brs, 1H), 10.17 (brs, 1H). 
     Ia-149 
     mp 220-222° C. 
       1 H-NMR (DMSO) δ ppm: 1.30 (s, 9H), 3.74 (s, 3H), 6.92 (d, 2H, J=9.0 Hz), 7.38 (d, 2H, J =9.0 Hz), 7.64 (d, 2H, J=9.0 Hz), 7.87 (d, 2H, J=9.0 Hz), 9.99 (s, 2H). 
     Ia-150 
     mp 264-266° C. 
       1 H-NMR (DMSO) δ ppm: 1.31 (s, 9H), 1.66-1.76 (m, 4H), 2.57-2.66 (m, 2H), 2.71-2.80 (m, 2H), 6.98 (m, 1H), 7.06-7.16 (m, 2H), 7.38 (d, 2H, J=9.0 Hz), 7.90 (d, 2H, J=8.7 Hz), 9.60 (s, 1H), 9.99 (s, 1H). 
     Ia-151 
     mp 235-236° C. 
       1 H-NMR (DMSO) δ ppm: 1.03-1.39 (m, 5H), 1.27 (s, 9H), 1.55-1.87 (m, 5H), 3.73 (m, 1H), 7.31 (d, 2H, J=8.7 Hz), 7.76 (d, 2H, J=8.4 Hz), 8.01 (d, 1H, J=7.8 Hz), 9.90 (s, 1H). 
     Ia-152 
     mp 244-246° C. 
       1 H-NMR (DMSO) δ ppm: 0.50-0.72 (m, 4H), 1.27 (s, 9H), 2.81 (m, 1H), 7.31 (d, 2H, J=8.7 Hz), 7.73 (d, 2H, J=8.7 Hz), 8.30 (d, 1H, J=4.2 Hz), 9.91 (brs, 1H). 
     Ia-153 
     mp &gt;300° C. 
       1 H-NMR (DMSO) δ ppm: 1.06 (m, 6H), 1.27 (s, 9H), 1.2-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.25 (m, 1H), 2.7 (m, 1H), 3.05 (m, 1H), 3.51 (m, 4H), 4.30 (m, 1H), 6.80 (d, 1H, J=8.4), 7.34 (d, 2H, J=8.4), 7.65 (d, 2H, J=8.4), 10.01 (s, 1H). 
     Ia-154 
     mp 247-249° C. 
       1 H-NMR (DMSO) δ ppm: 1.05 (m, 6H), 1.27 (s, 9H), 1.2-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.23 (m, 1H), 2.77 (m, 1H), 3.05 (m, 1H), 3.52 (m, 4H), 4.33 (m, 1H), 6.80 (d, 1H, J=9.0), 7.03 (d, 1H, J=7.8), 7.35 (t, 1H, J=7.8), 7.59 (d, 1H, J=7.8), 7.68 (s, 1H), 9.96 (s, 1H). 
     Ia-155 
     mp 258-259° C. 
       1 H-NMR (DMSO) δ ppm: 1.25 (m, 2H), 1.50 (m, 2H), 1.86 (m, 2H), 1.99 (m, 2H), 2.28 (m, 1H) 2.93 (s, 3H), 3.10 (m, 1H), 7.02 (d, 1H, J=7.5), 7.65 (d, 2H, J=8.4), 7.80 (d, 2H, J=8.4), 10.20 (s, 1H). 
     Ia-156 
     mp 250-253° C. 
       1 H-NMR (DMSO) δ ppm: 1.28 (m, 2H), 1.50 (m, 2H), 1.82 (m, 2H), 2.00 (m, 4H), 2.22 (m, 1H), 2.79 (m, 4H), 2.92 (s, 3H), 3.11 (m, 1H), 7.01 (d, 1H, J=(0.1), 7.26 (d, 1H, J=8.1), 7.51 (s, 1H), 9.68 (s, 1H). 
     Ia-157 
     mp 259-262° C. 
       1 H-NMR (DMSO) δ ppm: 1.13 (d, 6H, J=6.0), 1.25 (m, 2H), 1.50 (m, 2H), 1.80 (m, 2H), 1.95 (m, 2H), 2.17 (m, 3H), 2.92 (s, 3H), 3.10 (m, 1H), 3.70 (m, 2H), 3.68 (m, 2H), 6.86 (d, 2H, J=9.3), 7.00 (d, 1H, J=7.2), 7.43 (d, 2H, J=9.3), 9.58 (s, 1H). 
     Ia-158 
     mp 298-300° C. 
       1 H-NMR (DMSO) δ ppm: 1.31 (s, 9H), 7.30-7.50 (m, 5H), 7.63-7.71 (m, 4H), 7.87 (d, 2H, J=8.7 Hz), 7.91 (d, 2H, J=9.0 Hz), 10.03 (brs, 1H), 10.22 (brs, 1H). 
     Ia-159 
     mp 278-281° C. 
       1 H-NMR (DMSO) δ ppm: 0.74-1.87 (m, 20H), 1.29 (s, 9H), 3.76 (m, 1H), 7.32 (d, 2H, J=8.4 Hz), 7.75 (d, 2H, J=8.7 Hz), 7.75 (d, 1H, J=8.7 Hz), 7.90 (brs, 1H). 
     Ia-160 
     mp 227-228° C. 
       1 H-NMR (DMSO) δ ppm: 1.22-1.55 (m, 4H), 1.27 (s, 9H), 1.80-2.02 (m, 4H), 2.23 (m, 1H), 3.06 (m, 1H), 6.78 (d, J=8.7 Hz), 7.45 (t, 1H, J=9.9 Hz), 7.82 (m, 1H), 8.12 (d-d, 1H, J=2.4 Hz, 6.3 Hz), 10.17 (brs, 1H). 
     Ia-161 
     mp 259-260° C. 
       1 H-NMR (DMSO) δ ppm: 1.22-1.54 (m, 4H), 1.27 (s, 9H), 1.78-2.01 (m, 4H), 2.16 (s, 3H), 2.21 (m, 1H), 3.05 (m, 1H), 6.77 (d, 1H, J=8.4 Hz), 7.12-7.21 (m, 2H), 7.53 (m, 1H), 9.90 (brs, 1H). 
     Ia-162 
     mp 222-226° C. 
       1 H-NMR (DMSO) δ ppm: 1.15 (d, 6H, J=6.3 Hz), 1.26 (d, 6H, J=6.9 Hz), 2.16-2.26 (m, 2H), 3.31 (m, 1H), 3.48-3.58 (m, 2H), 3.63-3.76 (m, 2H), 6.92 (d, 2H, J=9.0H), 7.32 (d, 2H, J=8.7 Hz), 7.59 (d, 2H, 9.0 Hz), 7.89 (d, 2H, J=9.0 Hz), 9.92 (s, 1H), 10.13 (brs, 1H). 
     Ia-163 
     mp 197-200° C. 
       1 H-NMR (DMSO) δ ppm: 1.26 (d, 6H, J=6.3 Hz), 1.95-2.09 (m, 2H), 2.77-2.90 (m, 4H), 3.32 (m, 1H), 7.17 (d, 1H, J=8.1 Hz), 7.32 (d, 2H, J=8.7 Hz), 7.45 (d-d, 1H, J=1.8 Hz, 8.1 Hz), 7.64 (brs, 1H), 7.90 (d, 2H, J=8.7 Hz), 9.99 (brs, 1H), 10.13 (brs, 1H). 
     Ia-164 
     mp 145-247° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.3-2.0 (m, 16H), 2.19 (m, 1H), 3.05 (m, 1H), 4.74 (m, 1H), 6.79 (d, 1H, J=9.0), 6.80 (d, 2H, J=9.0), 7.47 (d, 2H, J=9.0), 9.63 (s, 1H). 
     Ia-165 
     mp &gt;300° C. 
       1 H-NMR (DMSO) δ ppm: 1.03-2.02 (m, 18H), 1.27 (s, 9H), 2.26 (m, 1H), 3.06 (m, 1H), 3.73 (m, 1H), 6.78 (d, 1H, J=8.7 Hz), 7.63 (d, 2H, J=9.0 Hz), 7.78 (d, 2H, J=8.7 Hz), 8.02 (d, 1H, J=8.1 Hz), 10.00 (brs, 1H). 
     Ia-166 
     mp 200-201° C. 
       1 H-NMR (DMSO) δ ppm: 1.03-2.02 (m, 18H), 1.27 (s, 9H), 2.25 (m, 1H), 3.06 (m, 1H), 3.73 (m, 1H), 6.78 (d, 1H, J=8.7 Hz), 7.33 (t, 1H, J=8.1 Hz), 7.46 (d, 1H, J=8.1 Hz), 7.76 (m, 1H), 7.94 (m, 1H), 8.14 (d, 1H, J=8.1 Hz), 9.92 (brs, 1H). 
     Ia-167 
     mp 282-285° C. 
       1 H-NMR (DMSO) δ ppm: 1.22-1.57 (m, 4H), 1.27 (s, 9H), 1.87-2.03 (m, 4H), 2.49 (m, 1H), 3.07 (m, 1H), 6.83 (d, 1H, J=8.7 Hz), 13.20 (brs, 1H). 
     Ia-168 
     mp 120-124° C. 
       1 H-NMR (DMSO) δ ppm: 0.94-1.66 (m, 14H), 1.27 (s, 9H), 1.80-2.04 (m, 4H), 2.25 (m, 1H), 2.92 (m, 1H), 3.06 (m, 1H), 6.78 (d, 1H, J=8.7 Hz), 7.42-7.53 (m, 2H), 7.63 (d, 1H, J=7.2 Hz), 7.73 (m, 1H), 8.17 (m, 1H), 10.11 (brs, 1H). 
     Ia-169 
     mp 256-257° C. 
       1 H-NMR (DMSO) δ ppm: 0.93-1.20 (m, 5H), 1.24-1.64 (m, 9H), 1.27 (s, 9H), 1.80-2.02 (m, 4H), 2.27 (m, 1H), 2.87 (m, 1H), 3.06 (m, 1H), 6.79 (d, 1H, J=9.0 Hz), 7.48 (d, 1H, J=7.2 Hz), 7.68-7.79 (m, 4H), 10.17 (brs, 1H). 
     Ia-171 
     mp 242-244° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (m, 12H), 1.45 (m, 4H), 1.90 (m, 4H), 2.25 (m, 1H), 3.07 (m, 1H), 3.67 (m, 2H), 6.77 (d, 1H, J=8.7), 6.90 (d, 1H, J=7.8), 7.31 (t, 1H, J=7.5), 7.53 (d, 1H, J=7.8), 7.59 (s, 1H), 9.89 (s, 1H). 
     Ia-172 
     mp &gt;310° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (m, 12H), 1.38 (m, 4H), 1.84 (m, 2H), 1.97 (m, 2H), 2.25 (m, 1H), 3.07 (m, 1H), 3.36 (m, 2H), 6.81 (d, 1H, J=8.7), 7.20 (d, 2H, J=6.7), 7.61 (d, 2H, J=8.7), 9.94 (s, 1H). 
     Ia-173 
     mp 279-281° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.3-1.5 (m, 4H), 1.83 (m, 6H), 1.93 (m, 2H), 2.21 (m, 1H), 2.36 (m, 2H), 3.05 (m, 1H), 3.54 (m, 2H), 6.79 (d, 1H, J=8.7), 7.16 (d, 2H, J=9.0), 7.56 (d, 2H, J=9.0), 9.83 (s, 1H). 
     Ia-174 
     mp 258-262° C. 
       1 H-NMR (DMSO) δ ppm: 0.29 (m, 2H), 0.53 (m, 2H), 1.20 (m, 1H), 1.27 (s, 9H), 1.3-1.5 (m, 4H), 1.7-2.0 (m, 4H), 2.20 (m, 1H), 3.05 (m, 1H), 3.75 (d, 2H, J=6.9), 6.79 (d, 1H, J=9.0), 6.83 (d, 2H, J=9.0), 7.46 (d, 2H, J=9.0), 9.64 (s, 1H). 
     Ia-175 
     mp 246-248° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.3-2.0 (m, 18H), 2.19 (m, 1H), 3.04 (m, 1H), 4.23 (m, 1H), 6.79 (d, 1H, J=8.7), 6.84 (d, 2H, J=9.0), 7.45 (d, 2H, J=9.0), 9.64 (s, 1H). 
     Ia-176 
     mp 200-202° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.3-2.0 (m, 18H), 2.21 (m, 1H), 3.05 (m, 1H), 4.23 (m, 1H), 6.57 (d, 1H, J=6.9), 6.80 (d, 1H, J=9.0), 7.0-7.2 (m, 2H), 7.28 (s, 1H), 9.74 (s, 1H). 
     Ia-177 
     mp 266-268° C. 
       1 H-NMR (DMSO) δ ppm: 1.22-1.56 (m, 4H), 1.27 (s, 9H), 1.79-2.02 (m, 4H), 2.25 (m, 1H), 3.05 (m, 1H), 6.56 (m, 1H), 6.77-6.84 (m, 2H), 7.58-7.71 (m, 5H), 9.92 (brs, 1H). 
     Ia-178 
     mp 223-224° C. 
       1 H-NMR (DMSO) δ ppm: 1.26-1.54 (m, 4H), 1.27 (s, 9H), 1.81-2.02 (m, 4H), 2.45 (m, 1H), 3.06 (m, 1H), 6.80 (d, 1H, J=8.7 Hz), 8.15 (d-d, 1H, J=2.4 Hz, 9.0 Hz), 8.27 (d, 1H, J=9.0 Hz), 8.70 (m, 1H), 10.85 (brs, 1H). 
     Ia-179 
     mp 224-227° C. 
       1 H-NMR (DMSO) δ ppm: 1.24-1.56 (m, 4H), 1.27 (s, 9H), 1.80-2.03 (m, 4H), 2.27 (m, 1H), 3.06 (m, 1H), 6.80 (d, 1H, J=8.7 Hz), 6.90 (d, 1H, J=1.8 Hz), 7.72-7.84 (m, 4H), 8.60 (d, 1H, J=1.8 Hz), 10.09 (brs, 1H). 
     Ia-180 
     mp 226-227° C. 
       1 H-NMR (DMSO) δ ppm: 0.92 (d, 6H, J=6.6 Hz), 1.26-1.55 (m, 4H), 1.27 (s, 9H), 1.80-2.03 (m, 4H), 2.27 (m, 1H), 3.05 (m, 1H), 3.20 (m, 1H), 6.80 (d, 1H, J=8.7 Hz), 7.42 (d, 1H, J=7.2 Hz), 7.67-7.79 (m, 4H), 10.19 (brs, 1H). 
     Ia-181 
     mp 191-192° C. 
       1 H-NMR (DMSO) δ ppm: 0.95 (d, 6H, J=6.6 Hz), 1.26-1.55 (m, 4H), 1.27 (s, 9H), 1.80-2.03 (m, 4H), 2.25 (m, 1H), 3.06 (m, 1H), 3.23 (m, 1H), 6.80 (d, 1H, J=8.4 Hz), 7.41-7.53 (m, 2H), 7.58 (d, 1H, J=7.2 Hz), 7.73 (m, 1H), 8.18 (m, 1H), 10.13 (brs, 1H). 
     Ia-182 
     mp 192-193° C. 
       1 H-NMR (DMSO) δ ppm: 0.30 (m, 2H), 0.55 (m, 2H), 1.2-1.5 (m, 5H), 1.27 (s, 1H), 1.8-2.0 (m, 4H), 2.20 (m, 1H), 3.04 (m, 1H), 3.75 (d, 2H, J=6.9), 6.58 (m, 1H), 6.79 (d, 1H, J=8.7), 7.0-7.2 (m, 2H), 7.31 (s, 1H), 9.76 (s, 1H). 
     Ia-183 
     mp &gt;310° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.3-1.5 (m, 4H), 1.82 (m, 2H), 1.97 (m, 2H), 2.04 (m, 2H), 2.39 (m, 1H), 2.46 (t, 2H, J=7.8), 3.07 (m, 1H), 3.79 (t, 2H, J=7.5), 6.79 (d, 1H, J=8.7), 7.56 (m, 4H), 9.80 (s, 1H). 
     Ia-184 
     mp 281-283° C. 
       1 H-NMR (DMSO) δ ppm: 1.24-1.57 (m, 4H), 1.27 (s, 9H), 1.80-2.04 (m, 4H), 2.27 (m, 1H), 3.06 (m, 1H), 6.80 (d, 1H, J=9.0 Hz), 7.33 (s, 1H), 7.75 (d, 2H, J=9.3 Hz), 7.91 (d, 2H, J=8.7 Hz), 8.16 (s, 1H), 10.09 (brs, 1H). 
     Ia-185 
     mp 226-227° C. 
       1 H-NMR (DMSO) δ ppm: 1.24-1.58 (m, 10H), 1.27 (s, 9H), 1.81-2.02 (m, 4H), 2.28 (m, 1H), 2.78-2.88 (m, 4H), 3.06 (m, 1H), 6.80 (d, 1H, J=8.7 Hz), 7.64 (d, 2H, J=8.7 Hz), 7.82 (d, 2H, J=8.7 Hz), 10.25 (brs, 1H). 
     Ia-186 
     mp 148-150° C. 
       1 H-NMR (DMSO) δ ppm: 1.25-1.60 (m, 10H), 1.27 (s, 9H), 1.82-2.03 (m, 4H), 2.24 (m, 1H), 2.82-2.92 (m, 4H), 3.06 (m, 1H), 6.79 (d, 1H, J=8.4 Hz), 7.36 (m, 1H), 7.55 (t, 1H, J=7.8 Hz), 7.84 (m, 1H), 8.06 (m, 1H), 10.18 (brs, 1H). 
     Ia-187 
     mp &gt;310° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.36 (s, 9H), 1.43 (m, 4H), 1.85 (m, 2H), 1.93 (m, 2H), 2.27 (m, 1H), 3.06 (m, 1H), 6.80 (d, 1H, J=8.7), 7.58 (s, 1H), 7.62 (d, 2H), 7.75 (d, 2H, J=9.0), 10.00 (s, 1H). 
     Ia-188 
     mp 285-292° C. 
       1 H-NMR (DMSO) δ ppm: 0.85 (t, 3H, J=7.5), 1.11 (d, 3H, J=6.3), 1.26 (s, 9H), 1.3-1.6 (m, 6H), 1.85 (m, 2H), 1.95 (m, 2H), 2.27 (m, 1H), 3.06 (m, 1H), 3.90 (m, 1H), 6.80 (d, 1H, J=8.4), 7.64 (d, 2H, J=8.7), 7.79 (d, 2H, J=8.7), 7.99 (d, 1H, J=8.1), 10.02 (s, 1H). 
     Ia-189 
     mp 278-281° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.2-2.0 (m, 17H), 2.03 (m, 2H), 3.03 (m, 1H), 6.79 (d, 1H, J=8.4), 7.1-7.3 (m, 3H), 7.94 (s, 1H), 9.78 (m, 2H). 
     Ia-190 
     mp &gt;310° C. 
       1 H-NMR (DMSO) δ ppm: 1.1-2.0 (m, 17H), 1.27 (s, 9H), 2.25 (m, 2H), 3.03 (m, 1H), 6.79 (d, 1H, J=8.7), 7.48 (m, 4H), 9.71 (m, 2H). 
     Ia-191 
     mp 275-277° C. 
       1 H-NMR (DMSO) δ ppm: 1.16 (d, 6H, J=6.6 Hz), 1.31 (s, 9H), 4.09 (m, 1H), 7.41 (d, 2H, J=8.7 Hz), 7.84 (s, 4H), 7.90 (d, 2H, J=9.0 Hz), 8.11 (d, 1H, J=7.5 Hz), 10.04 (brs, 1H), 10.30 (brs, 1H). 
     Ia-192 
     mp 204-205° C. 
       1 H-NMR (DMSO) δ ppm: 1.15 (d, 6H, J=6.6 Hz), 1.20-1.56 (m, 4H), 1.22 (d, 6H, J=6.6 Hz), 1.78-2.00 (m, 4H), 2.25 (m, 1H), 2.98-3.22 (m, 2H), 4.06 (m, 1H), 6.99 (d, 1H, J=8.1 Hz), 7.34 (t, 1H, J=8.1 Hz), 7.46 (d, 1H, J=7.8 Hz), 7.75 (m, 1H), 7.96 (m, 1H), 8.17 (d, 1H, J=8.7 Hz), 9.94 (brs, 1H). 
     Ia-193 
     mp 285-286° C. 
       1 H-NMR (DMSO) δ ppm: 1.15 (d, 6H, J=6.6 Hz), 1.20-1.56 (m, 4H), 1.22 (d, 6H, J=6.9 Hz), 1.79-2.00 (m, 4H), 2.26 (m, 1H), 2.97-3.20 (m, 2H), 4.07 (m, 1H), 6.99 (d, 1H, J=7.8 Hz), 7.64 (d, 2H, J=8.7 Hz), 7.79 (d, 2H, J=8.7 Hz), 8.06 (d, 1H, J=7.5 Hz), 10.02 (brs, 1H). 
     Ia-194 
     mp 248-250° C. 
       1 H-NMR (DMSO) δ ppm: 1.22-1.57 (m, 4H), 1.22 (d, 6H, J=6.6 Hz), 1.78-2.00 (m, 4H), 2.25 (m, 1H), 2.98-3.22 (m, 2H), 6.56 (m, 1H), 6.82 (d, 1H, J=3.3 Hz), 6.99 (d, 1H, J=7.8 Hz), 7.58-7.71 (m, 5H), 9.92 (brs, 1H). 
     Ia-195 
     mp 271-275° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.28-1.56 (m, 4H), 1.80-2.02 (m, 4H), 2.25 (m, 1H), 3.06 (m, 1H), 6.80 (d, 1H, J=9.0 Hz), 7.57 (s, 1H), 7.62-7.74 (m, 4H), 8.39 (s, 1H), 9.99 (brs, 1H). 
     Ia-196 
     mp 226-228° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.30 (m, 2H), 1.23 (d, 6H, J=6.9), 1.2-2.0 (m, 4H), 2.20 (m, 1H), 3.10 (m, 2H), 3.76 (d, 2H, J=6.9), 6.83 (d, 2H, J=8.7), 6.99 (d, 1H, J=8.1), 7.46 (d, 2H, J=8.7), 9.65 (s, 1H). 
     Ia-197 
     mp 173-175° C. 
       1 H-NMR (DMSO) δ ppm: 0.31 (m, 2H), 0.56 (m, 2H), 1.22 (d, 6H, J=6.6), 1.2-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.22 (m, 1H), 3.10 (m, 1H), 3.76 (d, 1H, J=7.2), 6.58 (d, 1H, J=8.1), 7.0-7.2 (m, 2H), 7.32 (s, 1H), 9.78 (s, 1H). 
     Ia-198 
     mp 233-235° C. 
       1 H-NMR (DMSO) δ ppm: 1.25 (d, 6H, J=6.9), 1.2-2.0 (m, 16H), 2.19 (m, 1H), 3.10 (m, 2H), 4.73 (m, 1H), 6.80 (d, 2H, J=8.7), 6.98 (d, 1H, J=7.8), 7.45 (d, 2H, J=8.7), 9.63 (s, 1H). 
     Ia-199 
     mp 185-186° C. 
       1 H-NMR (DMSO) δ ppm: 1.22 (d, 6H, J=6.9), 1.2-2.0 (m, 16H), 2.22 (m, 1H), 3.10 (m, 2H), 4.73 (m, 1H), 6.54 (m, 1H), 7.0-7.2 (m, 2H), 7.3 (s, 1H), 9.75 (s, 1H). 
     Ia-200 
     mp 235-237° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.3-1.6 (m, 6H), 1.8-2.0 (m, 6H), 2.20 (m, 1H), 3.05 (m, 1H), 3.45 (m, 2H), 3.82 (m, 2H), 4.47 (m, 1H), 6.79 (d, 1H, J=9.0), 6.89 (d, 2H, J=9.0), 7.47 (d, 2H, J=9.0), 9.66 (s, 1H). 
     Ia-201 
     mp 300-301° C. 
       1 H-NMR (DMSO) δ ppm: 1.15 (d, 6H, J=6.6 Hz), 1.26-1.56 (m, 4H), 1.27 (s, 9H), 1.82-2.03 (m, 4H), 2.23 (s, 3H), 2.37 (m, 1H), 3.06 (m, 1H), 4.07 (m, 1H), 6.81 (d, 1H, J=8.7 Hz), 7.52 (d, 1H, J=8.4 Hz), 7.62 (d, 1H, J=8.4 Hz), 7.68 (s, 1H), 8.09 (d, 1H, J=7.5 Hz), 9.22 (brs, 1H). 
     Ia-202 
     mp 269-270° C. 
       1 H-NMR (DMSO) δ ppm: 1.25-1.26 (m, 4H), 1.27 (s, 9H), 1.80-2.03 (m, 4H), 2.25 (m, 1H), 3.07 (m, 1H), 6.80 (d, 1H, J=8.4 Hz), 7.11 (m, 1H), 7.42 (d, 1H, J=3.6 Hz), 7.48 (m, 1H), 7.58 (d, 2H, J=8.7 Hz), 7.64 (d, 2H, J=8.4 Hz), 9.92 (brs, 1H). 
     Ia-203 
     mp 271-273° C. 
       1 H-NMR (DMSO) δ ppm: 1.14-1.54 (m, 9H), 1.26 (s, 9H), 1.63-1.88 (m, 7H), 1.89-2.01 (m, 2H), 2.21 (m, 1H), 2.42 (m, 1H), 3.04 (m, 1H), 6.79 (d, 1H, J=9.0 Hz), 7.11 (d, 2H, J=8.4 Hz), 7.47 (d, 2H, J=8.1 Hz), 9.70 (brs, 1H). 
     Ia-204 
     mp 250-251° C. 
       1 H-NMR (DMSO) δ ppm: 1.22-1.39 (m, 2H), 1.22 (d, 6H, J=6.6 Hz), 1.40-1.57 (m, 2H), 1.80-2.01 (m, 4H), 2.28 (m, 1H), 2.98-3.21 (m, 2H), 7.00 (d, 1H, J=7.8 Hz), 7.34 (s, 1H), 7.75 (d, 2H, J=9.0 Hz), 7.91 (d, 2H, J=8.7 Hz), 8.17 (s, 1H), 10.10 (brs, 1H). 
     Ia-205 
     mp 239-240° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.2-1.5 (m, 4H), 1.8-2.0 (m, 5H), 2.08 (m, 2H), 3.05 (m, 1H), 3.80 (m, 4H), 4.95 (m, 1H), 6.79 (d, 1H, J=8.7), 6.83 (d, 2H, J=8.7), 7.48 (d, 2H, J=8.7), 9.66 (s, 1H). 
     Ia-206 
     mp 236-238° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.2-1.7 (m, 8H), 1.8-2.0 (m, 6H), 2.18 (m, 1H), 3.04 (m, 1H), 3.3-3.6 (m, 2H), 3.85 (m, 3H), 6.80 (d, 1H, J=9.0), 6.84 (d, 2H, J=9.0), 7.47 (d, 2H, J=9.0), 9.65 (s, 1H). 
     Ia-207 
     mp 224-226° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.2-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.24 (m, 1H), 2.39 (m, 2H), 3.06 (m, 1H), 3.50 (t, 2H, J=7.5), 3.70 (t, 2H, J=6.3), 6.78 (d, 1H, J=6.6), 6.83 (m, 1H), 7.25 (m, 1H), 7.27 (m, 1H), 7.54 (s, 1H), 9.61 (s, 1H). 
     Ia-208 
     mp 275-277° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.3-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.22 (m, 1H), 2.38 (m, 2H), 3.07 (m, 1H), 3.47 (t, 2H, J=6.9), 3.69 (t, 2H, J=6.6), 6.80 (d, 1H, J=8.7), 7.14 (d, 2H, J=8.4), 7.58 (d, 2H, J=8.4), 9.83 (s, 1H). 
     Ia-209 
     mp 214-215° C. 
       1 H-NMR (DMSO) δ ppm: 1.26-1.56 (m, 4H), 1.27 (s, 9H), 1.80-2.03 (m, 4H), 2.25 (m, 1H), 3.06 (m, 1H), 6.59 (m, 1H), 6.81 (d, 1H, J=8.4 Hz), 6.86 (d, 1H, J=2.7 Hz), 7.28-7.40 (m, 2H), 7.47 (m, 1H), 7.75 (s, 1H), 8.01 (s, 1H), 9.91 (brs, 1H). 
     Ia-210 
     mp 272-275° C. 
       1 H-NMR (DMSO) δ ppm: 1.31 (s, 9H), 6.59 (m, 1H), 6.87 (d, 1H, J=3.3 Hz), 7.41 (d, 2H, J=8.7 Hz), 7.68 (d, 2H, J=8.7 Hz), 7.72 (m, 1H), 7.83 (d, 2H, J=8.7 Hz), 7.90 (d, 2H, J=8.7 Hz), 10.03 (brs, 1H), 10.22 (brs, 1H). 
     Ia-211 
     mp 251-255° C. 
       1 H-NMR (DMSO) δ ppm: 1.31 (s, 9H), 7.36 (s, 1H), 7.41 (d, 2H, J=8.4 Hz), 7.91 (d, 2H, J =8.4 Hz), 7.92-8.00 (m, 4H), 8.19 (s, 1H), 10.06 (brs, 1H), 10.38 (brs, 1H). 
     Ia-212 
     mp 241-244° C. 
       1 H-NMR (DMSO) δ ppm: 1.30 (s, 9H), 1.50-1.78 (m, 6H), 1.81-1.97 (m, 2H), 4.78 (m, 1H), 6.87 (d, 2H, J=9.0 Hz), 7.38 (d, 2H, J=8.7 Hz), 7.61 (d, 2H, J=9.0 Hz), 7.87 (d, 2H, J=8.7 Hz), 9.97 (brs, 1H), 9.99 (brs, 1H). 
     Ia-213 
     mp 283-286° C. 
       1 H-NMR (DMSO) δ ppm: 1.31 (s, 9H), 7.12 (d-d, 1H, J=3.6 Hz, 5.1 Hz), 7.41 (d, 2H, J=9.0 Hz), 7.46 (m, 1H), 7.50 (d-d, 1H, J=1.2 Hz, 5.1 Hz), 7.64 (d, 2H, J=8.7 Hz), 7.82 (d, 2H, J=8.7 Hz), 7.90 (d, 2H, J=9.3 Hz), 10.03 (brs, 1H), 10.22 (brs, 1H). 
     Ia-216 
     mp 224-225° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.22 (d, 6H, J=6.9), 1.2-1.5 (m, 4H), 1.8-2.0 (m, 4H), 2.45 (m, 1H), 3.12 (m, 2H), 6.99 (d, 1H, J=8.1), 8.15 (m, 1H), 8.27 (d, 1H, J=9.0), 8.69 (s, 1H), 10.86 (s, 1H). 
     Ia-219 
     mp 270-272° C. 
       1 H-NMR (DMSO) δ ppm: 1.28 (s, 9H), 1.34-1.51 (m, 2H), 1.80-1.92 (m, 2H), 2.83-2.97 (m, 2H), 3.32 (m, 1H), 3.99-4.12 (m, 2H), 6.92 (d, 1H, J=8.7 Hz), 7.57 (d, 2H, J=8.7 Hz), 7.68 (d, 2H, J=9.0 Hz), 8.90 (brs, 1H). 
     Ia-220 
     mp 187-189° C. 
       1 H-NMR (DMSO) δ ppm: 1.28 (s, 9H), 1.31-1.51 (m, 2H), 1.78-1.90 (m, 2H), 2.78-2.93 (m, 2H), 3.30 (m, 1H), 3.97-4.09 (m, 2H), 6.90 (d, 1H, J=8.7 Hz), 7.06 (t, 2H, J=9.0 Hz), 7.44 (d-d, 2H, J=4.8 Hz, 9.0 Hz), 8.53 (brs, 1H). 
     Ia-221 
     mp 260-262° C. 
       1 H-NMR (DMSO) δ ppm: 1.12-1.50 (m, 7H), 1.28 (s, 9H), 1.63-1.90 (m, 7H), 2.40 (m, 1H), 2.76-2.91 (m, 2H), 3.28 (m, 1H), 3.96-4.09 (m, 2H), 6.90 (d, 1H, J=8.7 Hz), 7.06 (d, 2H, J=8.4 Hz), 7.32 (d, 2H, J=8.4 Hz), 8.40 (brs, 1H). 
     Ia-222 
     mp 265-267° C. 
       1 H-NMR (DMSO) δ ppm: 1.23 (d, 6H, J=6.6 Hz), 1.31-1.48 (m, 2H), 1.77-1.90 (m, 2H), 2.84-2.98 (m, 2H), 3.16 (m, 1H), 3.33 (m, 1H), 3.96-4.10 (m, 2H), 7.11 (d, 1H, J=7.8 Hz), 7.57 (d, 2H, J=8.7 Hz), 7.67 (d, 2H, J=8.4 Hz), 8.90 (brs, 1H). 
     Ia-223 
     mp 183-186° C. 
       1 H-NMR (DMSO) δ ppm: 1.23 (d, 6H, J=6.9 Hz), 1.28-1.47 (m, 2H), 1.76-1.88 (m, 2H), 2.80-3.16 (m, 2H), 3.16 (m, 1H), 3.32 (m, 1H), 3.94-4.07 (m, 2H), 7.00-7.14 (m, 3H), 7.44 (d-d, 2H, J=4.8 Hz, 9.0 Hz), 8.53 (brs, 1H). 
     Ia-224 
     mp 232-234° C. 
       1 H-NMR (DMSO) δ ppm: 1.12-1.46 (m, 7H), 1.23 (d, 6H, J=6.6 Hz), 1.63-1.87 (m, 7H), 2.40 (m, 1H), 2.78-2.93 (m, 2H), 3.15 (m, 1H), 3.31 (m, 1H), 3.94-4.07 (m, 2H), 7.06 (d, 2H, J =8.4 Hz), 7.09 (d, 1H, J=8.1 Hz), 7.32 (d, 2H, J=8.4 Hz), 8.39 (brs, 1H). 
     Ia-225 
     mp 222-224° C. 
       1 H-NMR (DMSO) δ ppm: 1.28 (s, 9H), 1.30-1.61 (m, 4H), 1.77-1.98 (m, 4H), 2.66-2.90 (m, 2H), 3.28 (m, 1H), 3.40-3.50 (m, 2H), 3.79-3.88 (m, 2H), 3.96-408 (m, 2H), 4.44 (m, 1H), 6.85 (d, 2H, J=9.0 Hz), 6.91 (d, 1H, J=9.0 Hz), 7.31 (d, 2H, J=9.3 Hz), 8.34 (brs, 1H). 
     Ia-226 
     mp 194-195° C. 
       1 H-NMR (CDCl 3 /DMSO) δ ppm: 1.39 (d, 6H, J=7.2 Hz), 1.66 (quintet, 2H, J=6.8 Hz), 1.87 (quintet, 2H, J=7.7 Hz), 2.47 (t, 2H, J=7.5 Hz), 3.11-3.22 (m, 1H), 3.21 (t, 2H, J=6.2 Hz), 5.00 (brs, 1H), 7.35-7.56 (m, 5H), 7.86 (d, 1H, J=8.4 Hz), 8.05 (dd, 1H, J=1.8, 8.1 Hz), 8.20 (d, 1H, J=1.8 Hz), 9.24 (s, 1H). 
     Ia-227 
     mp &gt;300° C. 
       1 H-NMR (DMSO) δ ppm: 1.22 (d, 6H, J=6.3 Hz), 1.20-1.40 (m, 4H), 1.74-2.10 (m, 4H), 2.20-2.40 (m, 1H), 2.39 (s, 3H), 3.00-3.30 (m, 2H), 6.25 (s, 1H), 6.99 (brs, 1H), 7.43-7.57 (m, 1H), 7.71 (d, 1H, J=8.1 Hz), 7.76 (s, 1H), 10.27 (s, 1H). 
     Ia-228 
     mp 168-169° C. 
       1 H-NMR (DMSO) δ ppm: 1.26 (s, 9H), 1.49 (quintet, 2H, J=7.5 Hz), 1.64 (quintet, 2H, J=7.4 Hz), 2.38 (t, 2H, J=7.2 Hz), 2.40 (s, 3H), 3.04 (q, 2H, J=6.5 Hz), 6.25 (s, 1H), 6.89 (t, 1H, J=6.0 Hz), 7.48 (dd, 1H, J=1.8, 8.4 Hz), 7.71 (d, 1H, J=8.4 Hz), 7.77 (d, 1H, J=1.8 Hz), 10.33 (s, 1H). 
     Ia-229 
     mp 174-175° C. 
       1 H-NMR (DMSO) δ ppm: 1.21 (d, 6H, J=6.6 Hz), 1.42-1.56 (m, 2H), 1.56-1.70 (m, 2H), 2.33-2.42 (m, 2H), 2.40 (s, 3H), 2.90-3.02 (m, 2H), 3.14 (septet, 1H, J=6.5 Hz), 6.26 (s, 1H), 6.99 (brs, 1H), 7.48 (d, 1H, J=8.4 Hz), 7.71 (d, 1H, J=8.7 Hz), 7.77 (s, 1H), 10.33 (s, 1H). 
     Ia-230 
     mp 194-195° C. 
       1 H-NMR (DMSO) δ ppm: 0.86 (d, 6H, J=6.9 Hz), 1.25-1.65 (m, 4H), 1.27 (s, 9H), 1.81-2.05 (m, 5H), 2.23-2.35 (m, 1H), 2.99-3.15 (m, 1H), 3.36 (d, 2H, J=7.2 Hz), 6.80 (d, 1H, J=8.4 Hz), 7.80 (d, 1H, J=8.4 Hz), 7.87 (d, 1H, J=8.4 Hz), 8.19 (s, 1H), 10.44 (s, 1H). 
     Ia-231 
     mp 221-222° C. 
       1 H-NMR (DMSO) δ ppm: 0.86 (d, 6H, J=6.9 Hz), 1.22-1.40 (m, 2H), 1.23 (d, 6H, J=6.9 Hz), 1.40-1.58 (m, 2H), 1.82-2.04 (m, 5H), 2.22-2.37 (m, 1H), 3.00-3.16 (m, 1H), 3.15 (septet, 1H, J=6.6 Hz), 3.36 (d, 2H, J=7.5 Hz), 6.99 (d, 1H, J=7.5 Hz), 7.80 (d, 1H, J=8.4 Hz), 7.86 (d, 1H, J=8.4 Hz), 8.19 (s, 1H), 10.45 (s, 1H). 
     Ia-232 
     mp 196-197° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (d, 6H, J=6.6 Hz), 1.42 (s, 1H), 1.60-1.70 (m, 2H), 1.88 (quintet, 2H, J=7.4 Hz), 2.02-2.20 (m, 1H), 2.46 (t, 2H, J=7.7 Hz), 3.29 (q, 2H, J=6.1 Hz), 3.48 (d, 2H, J=7.8 Hz), 4.26 (t, 1H, J=6.0 Hz), 7.76 (d, 1H, J=8.1 Hz), 7.90 (dd, 1H, J=1.8, 8.1 Hz), 8.07 (d, 1H, J=1.5 Hz), 8.39 (s, 1H). 
     Ia-233 
     mp 151-152° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 0.93 (d, 6H, J=6.6 Hz), 1.40 (d, 6H, J=6.6 Hz), 1.62-1.69 (m, 2H), 1.88 (quintet, 2H, J=7.3 Hz), 2.03-2.16 (m, 1H), 2.47 (t, 2H, J=7.5 Hz), 3.21 (septet, 1H, J=6.8 Hz), 3.23 (q, 2H, J=6.3 Hz), 3.48 (d, 2H, J=7.5 Hz), 4.43 (t, 1H, J=6.0 Hz), 7.76 (d, 1H, J=8.4 Hz), 7.91 (dd, 1H, J=1.8, 8.4 Hz), 8.06 (d, 1H, J=1.8 Hz), 8.36 (s, 1H). 
     Ia-234 
     mp 219-220° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.28 (s, 9H), 1.30-1.50 (m, 2H), 1.74-1.88 (m, 2H), 2.83 (t, 2H, J=11.1 Hz), 3.20-3.32 (m, 1H), 3.94-4.07 (m, 2H), 5.94 (s, 2H), 6.77 (d, 1H, J=8.8 Hz), 6.82 (dd, 1H, J=1.8, 8.7 Hz), 6.89 (d, 1H, J=8.7 Hz), 7.11 (d, 1H, J=1.8 Hz), 8.38 (s, 1H). 
     Ia-235 
     mp 280-282° C. 
       1 H-NMR (DMSO-d 6 ) δ ppm: 1.27 (s, 9H), 1.26-1.57 (m, 4H), 1.86-2.03 (m, 4H), 2.38-2.50 (m, 1H), 3.00-3.14 (m, 1H), 6.81 (d, 1H, J=8.4 Hz), 7.29 (t, 1H, J=8.4 Hz), 7.43 (t, 1H, J=7.5 Hz), 7.73 (d, 1H, J=8.4 Hz), 7.96 (d, 1H, J=7.5 Hz), 12.27 (s, 1H). 
     Ia-237 
     mp 204-205° C. 
       1 H-NMR (DMSO) δ ppm: 1.23 (d, 6H, J=6.6 Hz), 1.29-1.61 (m, 4H), 1.75-1.98 (m, 4H), 2.78-2.92 (m, 2H), 3.15 (m, 1H), 3.29 (m, 1H), 3.38-3.51 (m, 2H), 3.78-3.89 (m, 2H), 3.94-4.06 (m, 2H), 4.44 (m, 1H), 6.85 (d, 2H, J=9.0 Hz), 7.10 (d, 1H, J=7.8 Hz), 7.31 (d, 2H, J=9.3 Hz), 8.34 (brs, 1H). 
     Ia-238 
     mp 128-130° C. 
       1 H-NMR (DMSO) δ ppm: 1.26 (s, 9H), 1.41-1.53 (m, 2H), 1.55-1.68 (m, 2H), 2.44 (t, 2H, J =7.2 Hz), 2.98-3.07 (m, 2H), 6.90 (t, 1H, J=6.0 Hz), 8.16 (d-d, 1H, J=2.1 Hz, 8.7 Hz), 8.29 (d, 1H, J=8.7 Hz), 8.70 (m, 1H), 10.91 (brs, 1H). 
     Ia-239 
     mp 256-258° C. 
       1 H-NMR (DMSO) δ ppm: 1.26-1.53 (m, 4H), 1.26 (s, 9H), 1.76-2.00 (m, 4H), 2.23 (s, 3H), 2.39 (m, 1H), 3.04 (m, 1H), 6.80 (d, 1H, J=8.7 Hz), 7.57 (d-d, 1H, J=2.4 Hz, 8.4 Hz), 7.97 (d, 1H, J=8.4 Hz), 8.12 (m, 1H), 10.26 (brs, 1H). 
     Ia-240 
     mp 288-290° C. 
       1 H-NMR (DMSO) δ ppm: 1.26-1.53 (m, 4H), 1.27 (s, 9H), 1.78-1.90 (m, 4H), 2.40 (m, 1H), 3.04 (m, 1H), 6.81 (d, 1H, J=8.7 Hz), 7.07 (m, 1H), 7.75 (m, 1H), 8.07 (d, 1H, J=8.4 Hz), 8.29 (m, 1H), 10.36 (brs, 1H). 
     Ia-241 
     mp 249-250° C. 
       1 H-NMR (DMSO) δ ppm: 1.28 (s, 9H), 1.34-1.50 (m, 2H), 1.79-1.90 (m, 2H), 2.74-2.98 (m, 2H), 3.32 (m, 1H), 4.02-4.14 (m, 2H), 6.91 (d, 1H, J=8.4 Hz), 7.94 (d, 1H, J=9.0 Hz), 8.04 (d-d, 1H, J=2.1 Hz, 9.0 Hz), 8.60 (s, 1H), 9.76 (brs, 1H). 
     Ia-242 
     mp 250-252° C. 
       1 H-NMR (DMSO) δ ppm: 1.24 (s, 9H), 1.27 (s, 9H), 1.24-1.54 (m, 4H), 1.76-1.88 (m, 2H), 1.90-2.01 (m, 2H), 2.21 (m, 1H), 3.05 (m, 1H), 6.79 (d, 1H, J=8.7 Hz), 6.88 (d, 2H, J=9.0 Hz), 7.48 (d, 2H, J=9.0 Hz), 9.72 (brs, 1H). 
     mp 250-252° C. 
       1 H-NMR (DMSO) δ ppm: 1.15 (d, 6H, J=6.6 Hz), 1.28 (s, 9H), 1.35-1.52 (m, 2H), 1.78-1.92 (m, 2H), 2.20 (s, 3H), 2.81-2.96 (m, 2H), 3.33 (m, 1H), 3.96-4.16 (m, 3H), 6.92 (d, 1H, J=8.7 Hz), 7.27 (d, 1H, J=8.1 Hz), 7.60 (m, 1H), 7.66 (m, 1H), 8.06 (d, 1H, J=7.8 Hz), 8.14 (brs, 1H). 
     Ia-244 
     mp 211-213° C. 
       1 H-NMR (DMSO) δ ppm: 1.29 (s, 9H), 1.35-1.52 (m, 2H), 1.81-1.93 (m, 2H), 2.83-2.97 (m, 2H), 3.32 (m, 1H), 4.03-4.14 (m, 2H), 6.93 (d, 1H, J=8.7 Hz), 7.55 (d-d, 1H, J=2.1 Hz, 9.0 Hz), 7.94 (d, 1H, J=9.0 Hz), 8.29 (d, 1H, J=1.8 Hz), 8.78 (brs, 1H), 9.19 (s, 1H). 
     Ia-245 
     mp 196-197° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.2-1.6 (m, 6H), 1.8-2.0 (m, 6H), 2.23 (m, 1H), 3.05 (m, 1H), 3.73 (m, 4H), 4.99 (s, 1H), 6.79 (d, 1H, J=8.7), 7.13 (d, 1H, J=6.8), 7.22 (t, 1H, J=6.8), 7.49 (d, 1H, J=6.8), 7.72 (s, 1H), 9.78 (s, 1H). 
     Ia-246 
     mp 242-244° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.2-1.5 (m, 4H), 1.65 (m, 4H), 1.8-2.0 (m, 4H), 2.23 (m, 1H), 2.71 (m, 1H), 3.06 (m, 1H), 3.43 (m, 2H), 3.93 (m, 2H), 6.79 (d, 1H, J=8.7), 6.91 (d, 1H, J=8.7), 7.20 (t, 1H, J=7.5), 7.40 (d, 1H, J=7.5), 7.53 (s, 1H), 9.76 (s, 1H). 
     Ia-247 
     mp 242-245° C. 
       1 H-NMR (DMSO) δ ppm: 1.27 (s, 9H), 1.2-1.6 (m, 6H), 1.8-2.0 (m, 6H), 2.23 (m, 1H), 3.05 (m, 1H), 3.74 (m, 4H), 4.94 (brs, 1H), 6.79 (d, 1H, J=8.7), 7.38 (d, 1H, J=8.7), 7.52 (d, 1H, J=8.7), 9.76 (s, 1H). 
     Ia-248 
     mp 272-274° C. 
       1 H-NMR (CDCl 3 ) δ ppm: 1.27 (s, 9H), 1.2-1.5 (m, 4H), 1.62 (m, 4H), 1.8-2.0 (m, 4H), 2.22 (m, 1H), 2.68 (m, 1H), 3.05 (m, 1H), 3.41 (m, 2H), 3.92 (m, 2H), 6.79 (d, 1H, J=9.0), 7.15 (d, 2H, J=8.7), 7.50 (d, 2H, J=8.7), 9.73 (s, 1H). 
     Ia-249 mp 174-176° C. 
     Ia-250 mp 255-257° C. 
     Ia-252 mp 249-251° C. 
     Ia-253 mp 120-121° C. 
     Ia-254 mp 236-237° C. 
     Ia-255 mp 172-174° C. 
     Ia-256 mp 257-259° C. 
     Ia-257 mp 179-180° C. 
     Ia-258 mp 227-229° C. 
     Ia-259 mp 135-136° C. 
     Experiment 1 
     Affinity for NPY Y5 Receptor 
     cDNA sequence encoding a human NPY Y5 receptor (WO96/16542) was cloned in the expression vector pME18S (Takebe et al. Mol. Cell. Biol. 8, 8957). The obtained expression vector was transfected into a host CHO cells by using a Lipefect AMINE reagent (Trademark, Giro BRL Co. Ltd.) according to an instruction protocol to obtain the cells that stably express NPY Y5 receptor. 
     The membranes prepared from the above CHO cells expressing NPY Y5 receptor, the compound of the present invention and 30,000 cpm [ 125 I] peptide YY (60 pM of final concentration: Amersham) were incubated in the assay buffer (20 mM HEPES-Hanks buffer containing 0.1% bovine serum albumin, pH 7.4) at 25° C. for 2 hours and then the mixture was filtered with a glassfilter GF/C treated with polyethyleneimine. After the glassfilter was washed with 50 mM Tris-HCl buffer (pH 7.4), the radioactivity on the filter was measured with a gamma counter. The non-specific binding was detected in the presence of 200 nM of peptide YY. The 50% inhibitory concentration of the test compound against the specific peptide YY binding (IC 50  value) was calculated (Inui, A. et al. Endocrinology 131, 2090-2096 (1992)). The results are shown in Tables 1 and 2. 
     The compounds of the present invention inhibited the binding of peptide YY (NPY homologue) to NPY Y5 receptors. In other words, the compounds of the present invention showed affinity for the NPY Y5 receptor. 
     Experiment 2 
     cAMP Production Inhibitory Activity in CHO Cells 
     After CHO cells expressing human NPY Y5 receptor, were incubated in the presence of 2.5 mM isobutylmethylxanthine (SIGMA) at 37° C. for 20 min, the compound of the present invention was added and incubated for 5 min. Then, 50 nM NPY and 10 μM forskolin (SIGMA) were added to the cells and incubated for 30 min. After the reaction was terminated by adding 1N HCl, the amount of cAMP in the supernatant was measured with ETA kit (Amersham LIFE SCIENCE). The inhibitory activity of NPY against forskolin stimulated cAMP was regarded as 100% and the 50% inhibitory concentration (IC 50  value) of the compound of the present invention against the NPY activity was calculated. The results are shown in Tables 1 to 4. 
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 1 
               
               
                   
                   
               
               
                   
                   
                 binding 
                 cAMP 
               
               
                   
                 Compound 
                 IC 50 (nM) 
                 IC 50 (nM) 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 I-2 
                 7.5 
                 72 
               
               
                   
                 I-7 
                 3 
                 &lt;10 
               
               
                   
                 I-11 
                 1.3 
                 5 
               
               
                   
                 I-18 
                 4.4 
                 29 
               
               
                   
                 I-20 
                 7 
                 21 
               
               
                   
                 I-22 
                 8.6 
                 51 
               
               
                   
                 I-24 
                 9.6 
                 71 
               
               
                   
                 I-25 
                 0.6 
                 2.6 
               
               
                   
                 I-41 
                 5.3 
                 38.2 
               
               
                   
                 I-44 
                 1.0 
                 13.4 
               
               
                   
                 I-45 
                 1.2 
                 27.9 
               
               
                   
                 I-46 
                 0.8 
                 10.5 
               
               
                   
                 I-47 
                 0.6 
                 14.9 
               
               
                   
                 I-49 
                 0.4 
                 8.1 
               
               
                   
                 I-50 
                 0.3 
                 8.4 
               
               
                   
                 I-53 
                 4.1 
                 21 
               
               
                   
                 I-55 
                 9.0 
                 40 
               
               
                   
                 I-57 
                 4.8 
                 47 
               
               
                   
                 I-59 
                 0.8 
                 35 
               
               
                   
                 I-60 
                 0.69 
                 18 
               
               
                   
                 I-61 
                 0.26 
                 5.3 
               
               
                   
                 I-62 
                 0.58 
                 16 
               
               
                   
                 I-63 
                 1.3 
                 50 
               
               
                   
                 I-64 
                 2.2 
                 80 
               
               
                   
                 I-65 
                 1.8 
                 72 
               
               
                   
                 I-66 
                 1.5 
                 30 
               
               
                   
                 I-67 
                 2 
                 17 
               
               
                   
                 I-69 
                 3.8 
                 13 
               
               
                   
                 I-72 
                 2.3 
                 2.1 
               
               
                   
                 I-75 
                 0.55 
                 3.4 
               
               
                   
                 I-76 
                 0.61 
                 5.5 
               
               
                   
                 I-77 
                 1.8 
                 28 
               
               
                   
                 I-79 
                 0.59 
                 25 
               
               
                   
                 I-83 
                 0.61 
                 29 
               
               
                   
                 I-84 
                 1.3 
                 25 
               
               
                   
                 I-86 
                 3.4 
                 100 
               
               
                   
                 I-87 
                 0.66 
                 21 
               
               
                   
                 I-90 
                 2.8 
                 50 
               
               
                   
                 I-92 
                 7 
                 61 
               
               
                   
                 I-101 
                 3.9 
                 38 
               
               
                   
                 I-102 
                 1.7 
                 14 
               
               
                   
                 I-106 
                 6.4 
                 29 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 2 
               
               
                   
                   
               
             
            
               
                   
                 I-109 
                 1.2 
                 3.2 
               
               
                   
                 I-110 
                 4.3 
                 13.6 
               
               
                   
                 I-111 
                 1.8 
                 6.1 
               
               
                   
                 I-114 
                 7 
                 30 
               
               
                   
                 I-116 
                 1.2 
                 11 
               
               
                   
                 I-120 
                 1.4 
                 4.8 
               
               
                   
                 I-123 
                 1.8 
                 168 
               
               
                   
                 I-126 
                 0.6 
                 13.2 
               
               
                   
                 I-127 
                 1.4 
                 30.4 
               
               
                   
                 I-128 
                 1.3 
                 10.2 
               
               
                   
                 I-129 
                 2.1 
                 174 
               
               
                   
                 I-130 
                 1.1 
                 42.5 
               
               
                   
                 I-131 
                 1.1 
                 34.8 
               
               
                   
                 I-132 
                 2.2 
                 30.4 
               
               
                   
                 I-133 
                 0.9 
                 21.1 
               
               
                   
                 I-134 
                 0.5 
                 10.0 
               
               
                   
                 I-135 
                 0.7 
                 22.0 
               
               
                   
                 I-136 
                 2.8 
                 — 
               
               
                   
                 I-137 
                 1.4 
                 68.2 
               
               
                   
                 I-138 
                 1.0 
                 18.6 
               
               
                   
                 I-139 
                 0.41 
                 7.6 
               
               
                   
                 I-140 
                 0.48 
                 8.9 
               
               
                   
                 I-141 
                 0.42 
                 7.4 
               
               
                   
                 I-142 
                 0.49 
                 28 
               
               
                   
                 I-143 
                 3.5 
                 44 
               
               
                   
                 I-144 
                 3.4 
                 52 
               
               
                   
                 I-146 
                 2.3 
                 20 
               
               
                   
                 I-147 
                 7.1 
                 63 
               
               
                   
                 I-149 
                 0.83 
                 15 
               
               
                   
                 I-150 
                 0.17 
                 5.2 
               
               
                   
                 I-151 
                 0.17 
                 2.6 
               
               
                   
                 I-152 
                 0.88 
                 46 
               
               
                   
                 I-153 
                 1.7 
                 29 
               
               
                   
                 I-154 
                 1.1 
                 11 
               
               
                   
                 I-156 
                 0.81 
                 17 
               
               
                   
                 I-160 
                 0.61 
                 8.8 
               
               
                   
                 I-161 
                 0.49 
                 3.1 
               
               
                   
                 I-162 
                 1.7 
                 32 
               
               
                   
                 I-163 
                 2.3 
                 83 
               
               
                   
                 I-164 
                 0.71 
                 5.9 
               
               
                   
                 I-165 
                 0.44 
                 47 
               
               
                   
                 I-166 
                 0.37 
                 9.7 
               
               
                   
                 I-167 
                 0.72 
                 39 
               
               
                   
                 I-168 
                 2.1 
                 32 
               
               
                   
                 I-171 
                 2.4 
                 71 
               
               
                   
                 I-172 
                 0.91 
                 36 
               
               
                   
                 I-187 
                 0.58 
                 13 
               
               
                   
                 I-191 
                 1.1 
                 11 
               
               
                   
                 I-196 
                 1.4 
                 6.8 
               
               
                   
                 I-197 
                 6.7 
                 38 
               
               
                   
                 I-198 
                 7.2 
                 33 
               
               
                   
                 I-199 
                 4.8 
                 31 
               
               
                   
                 I-202 
                 6.7 
                 67 
               
               
                   
                 I-204 
                 1.0 
                 6.3 
               
               
                   
                 I-205 
                 2.9 
                 17 
               
               
                   
                 I-206 
                 5.9 
                 54 
               
               
                   
                 I-207 
                 4.6 
                 23 
               
               
                   
                 I-210 
                 1.1 
                 13 
               
               
                   
                 I-212 
                 0.67 
                 7.5 
               
               
                   
                 I-213 
                 0.44 
                 4.0 
               
               
                   
                 Ia-1 
                 4.8 
                 31 
               
               
                   
                 Ia-3 
                 9.2 
                 150 
               
               
                   
                 Ia-4 
                 1.4 
                 15 
               
               
                   
                 Ia-5 
                 1.6 
                 43 
               
               
                   
                 Ia-6 
                 2.4 
                 23 
               
               
                   
                 Ia-8 
                 2.9 
                 34 
               
               
                   
                 Ia-9 
                 0.94 
                 11 
               
               
                   
                 Ia-10 
                 0.47 
                 2.7 
               
               
                   
                 Ia-11 
                 0.64 
                 7.2 
               
               
                   
                 Ia-12 
                 0.94 
                 5.5 
               
               
                   
                 Ia-13 
                 1.5 
                 3.3 
               
               
                   
                 Ia-14 
                 4.8 
                 28 
               
               
                   
                 Ia-16 
                 0.1 
                 — 
               
               
                   
                 Ia-17 
                 0.1 
                 1.9 
               
               
                   
                 Ia-20 
                 4.9 
                 100 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 3 
               
               
                   
                   
               
             
            
               
                   
                 Ia-21 
                 3.4 
                 35 
               
               
                   
                 Ia-22 
                 3.1 
                 38 
               
               
                   
                 Ia-24 
                 5.2 
                 74 
               
               
                   
                 Ia-25 
                 1.1 
                 18 
               
               
                   
                 Ia-26 
                 1.9 
                 27 
               
               
                   
                 Ia-28 
                 5.2 
                 130 
               
               
                   
                 Ia-29 
                 1 
                 7.3 
               
               
                   
                 Ia-30 
                 2.6 
                 25 
               
               
                   
                 Ia-31 
                 3.8 
                 11 
               
               
                   
                 Ia-32 
                 0.52 
                 6.7 
               
               
                   
                 Ia-33 
                 1.8 
                 64 
               
               
                   
                 Ia-35 
                 1.8 
                 — 
               
               
                   
                 Ia-36 
                 1.6 
                 86 
               
               
                   
                 Ia-37 
                 0.73 
                 3.8 
               
               
                   
                 Ia-38 
                 1 
                 2.2 
               
               
                   
                 Ia-39 
                 1.5 
                 3.5 
               
               
                   
                 Ia-40 
                 2.2 
                 9.3 
               
               
                   
                 Ia-41 
                 2.5 
                 9 
               
               
                   
                 Ia-42 
                 3.6 
                 20 
               
               
                   
                 Ia-44 
                 4.8 
                 27 
               
               
                   
                 Ia-45 
                 4.8 
                 42 
               
               
                   
                 Ia-46 
                 0.87 
                 8.3 
               
               
                   
                 Ia-47 
                 0.82 
                 3.8 
               
               
                   
                 Ia-48 
                 1.2 
                 6.1 
               
               
                   
                 Ia-49 
                 2.6 
                 83 
               
               
                   
                 Ia-50 
                 1.7 
                 24 
               
               
                   
                 Ia-51 
                 1.3 
                 3.4 
               
               
                   
                 Ia-52 
                 1.9 
                 22 
               
               
                   
                 Ia-53 
                 0.22 
                 8.1 
               
               
                   
                 Ia-54 
                 0.44 
                 9 
               
               
                   
                 Ia-55 
                 1.1 
                 27 
               
               
                   
                 Ia-56 
                 2.3 
                 96 
               
               
                   
                 Ia-57 
                 0.93 
                 31 
               
               
                   
                 Ia-58 
                 2.5 
                 110 
               
               
                   
                 Ia-59 
                 0.71 
                 16 
               
               
                   
                 Ia-60 
                 0.95 
                 10 
               
               
                   
                 Ia-61 
                 0.68 
                 19 
               
               
                   
                 Ia-62 
                 1.1 
                 29 
               
               
                   
                 Ia-63 
                 3.9 
                 370 
               
               
                   
                 Ia-64 
                 7.1 
                 96 
               
               
                   
                 Ia-65 
                 1.1 
                 11 
               
               
                   
                 Ia-66 
                 0.59 
                 3.2 
               
               
                   
                 Ia-67 
                 6.3 
                 75 
               
               
                   
                 Ia-68 
                 9.5 
                 180 
               
               
                   
                 Ia-69 
                 2.7 
                 33 
               
               
                   
                 Ia-70 
                 1.5 
                 31 
               
               
                   
                 Ia-71 
                 1.3 
                 12 
               
               
                   
                 Ia-76 
                 2.2 
                 — 
               
               
                   
                 Ia-78 
                 2 
                 150 
               
               
                   
                 Ia-79 
                 0.82 
                 — 
               
               
                   
                 Ia-80 
                 0.44 
                 3.0 
               
               
                   
                 Ia-81 
                 2.7 
                 4.5 
               
               
                   
                 Ia-83 
                 1.2 
                 53 
               
               
                   
                 Ia-84 
                 0.25 
                 13 
               
               
                   
                 Ia-85 
                 0.22 
                 14 
               
               
                   
                 Ia-86 
                 0.73 
                 11 
               
               
                   
                 Ia-87 
                 0.49 
                 61 
               
               
                   
                 Ia-88 
                 0.62 
                 48 
               
               
                   
                 Ia-91 
                 4 
                 150 
               
               
                   
                 Ia-106 
                 1.9 
                 24 
               
               
                   
                 Ia-107 
                 0.14 
                 1.3 
               
               
                   
                 Ia-109 
                 0.6 
                 3.9 
               
               
                   
                 Ia-110 
                 0.3 
                 1.1 
               
               
                   
                 Ia-111 
                 5.1 
                 28 
               
               
                   
                 Ia-124 
                 1.1 
                 22 
               
               
                   
                 Ia-125 
                 4.1 
                 46 
               
               
                   
                 Ia-126 
                 2.3 
                 58 
               
               
                   
                 Ia-127 
                 6.1 
                 160 
               
               
                   
                 Ia-129 
                 1.3 
                 26 
               
               
                   
                 Ia-130 
                 0.21 
                 3 
               
               
                   
                 Ia-131 
                 1.3 
                 17 
               
               
                   
                 Ia-132 
                 2.8 
                 76 
               
               
                   
                 Ia-133 
                 1.7 
                 8.8 
               
               
                   
                 Ia-135 
                 8.2 
                 49 
               
               
                   
                 Ia-136 
                 1.6 
                 13 
               
               
                   
                 Ia-138 
                 2.2 
                 28 
               
               
                   
                 Ia-139 
                 1.9 
                 25 
               
               
                   
                 Ia-140 
                 1 
                 24 
               
               
                   
                 Ia-141 
                 1 
                 5.7 
               
               
                   
                 Ia-142 
                 0.67 
                 5.5 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 4 
               
               
                   
                   
               
             
            
               
                   
                 Ia-143 
                 7.8 
                 39 
               
               
                   
                 Ia-144 
                 6.1 
                 57 
               
               
                   
                 Ia-145 
                 7 
                 86 
               
               
                   
                 Ia-146 
                 9.9 
                 79 
               
               
                   
                 Ia-158 
                 0.71 
                 1.7 
               
               
                   
                 Ia-160 
                 0.76 
                 140 
               
               
                   
                 Ia-161 
                 1.9 
                 18 
               
               
                   
                 Ia-163 
                 7 
                 400 
               
               
                   
                 Ia-164 
                 0.38 
                 4.7 
               
               
                   
                 Ia-168 
                 0.95 
                 13 
               
               
                   
                 Ia-169 
                 1.9 
                 88 
               
               
                   
                 Ia-173 
                 6.9 
                 140 
               
               
                   
                 Ia-174 
                 0.35 
                 5.4 
               
               
                   
                 Ia-175 
                 0.49 
                 9.2 
               
               
                   
                 Ia-176 
                 0.63 
                 5.1 
               
               
                   
                 Ia-177 
                 0.49 
                 7.5 
               
               
                   
                 Ia-178 
                 4.6 
                 16 
               
               
                   
                 Ia-179 
                 0.89 
                 19 
               
               
                   
                 Ia-180 
                 1.9 
                 11 
               
               
                   
                 Ia-181 
                 7.7 
                 25 
               
               
                   
                 Ia-182 
                 0.24 
                 2.1 
               
               
                   
                 Ia-183 
                 1.9 
                 7.8 
               
               
                   
                 Ia-184 
                 0.38 
                 — 
               
               
                   
                 Ia-185 
                 0.94 
                 4.4 
               
               
                   
                 Ia-186 
                 0.93 
                 12 
               
               
                   
                 Ia-187 
                 1.9 
                 60 
               
               
                   
                 Ia-188 
                 0.75 
                 28 
               
               
                   
                 Ia-189 
                 3.5 
                 95 
               
               
                   
                 Ia-190 
                 0.34 
                 1000 
               
               
                   
                 Ia-191 
                 0.49 
                 220 
               
               
                   
                 Ia-192 
                 5.9 
                 200 
               
               
                   
                 Ia-193 
                 1.4 
                 43 
               
               
                   
                 Ia-194 
                 0.22 
                 8.1 
               
               
                   
                 Ia-195 
                 1.4 
                 31 
               
               
                   
                 Ia-196 
                 0.39 
                 1.3 
               
               
                   
                 Ia-197 
                 0.44 
                 2.5 
               
               
                   
                 Ia-198 
                 0.23 
                 2.6 
               
               
                   
                 Ia-199 
                 0.11 
                 1.6 
               
               
                   
                 Ia-200 
                 1.4 
                 18 
               
               
                   
                 Ia-201 
                 3.1 
                 74 
               
               
                   
                 Ia-202 
                 0.37 
                 3.4 
               
               
                   
                 Ia-203 
                 0.2 
                 2.6 
               
               
                   
                 Ia-204 
                 1 
                 6.3 
               
               
                   
                 Ia-205 
                 2.4 
                 99 
               
               
                   
                 Ia-206 
                 1.9 
                 460 
               
               
                   
                 Ia-207 
                 0.55 
                 5.9 
               
               
                   
                 Ia-208 
                 1.2 
                 9.7 
               
               
                   
                 Ia-209 
                 0.55 
                 — 
               
               
                   
                 Ia-210 
                 2.8 
                 99 
               
               
                   
                 Ia-211 
                 4.8 
                 240 
               
               
                   
                 Ia-212 
                 0.52 
                 2.6 
               
               
                   
                 Ia-213 
                 0.91 
                 28 
               
               
                   
                 Ia-219 
                 2.5 
                 28 
               
               
                   
                 Ia-221 
                 0.47 
                 1.5 
               
               
                   
                 Ia-222 
                 3.7 
                 18 
               
               
                   
                 Ia-224 
                 0.1 
                 1.2 
               
               
                   
                 Ia-225 
                 3.4 
                 20 
               
               
                   
                 Ia-226 
                 0.37 
                 21 
               
               
                   
                 Ia-227 
                 0.59 
                 — 
               
               
                   
                 Ia-228 
                 0.96 
                 — 
               
               
                   
                 Ia-229 
                 1.9 
                 — 
               
               
                   
                 Ia-230 
                 0.32 
                 — 
               
               
                   
                 Ia-231 
                 0.29 
                 — 
               
               
                   
                 Ia-232 
                 0.7 
                 — 
               
               
                   
                 Ia-233 
                 0.63 
                 — 
               
               
                   
                 Ia-235 
                 5.5 
                 — 
               
               
                   
                 Ia-237 
                 1.1 
                 15 
               
               
                   
                 Ia-241 
                 1.9 
                 — 
               
               
                   
                 Ia-243 
                 1.3 
                 — 
               
               
                   
                 Ia-246 
                 0.26 
                 20 
               
               
                   
                 Ia-247 
                 0.79 
                 31 
               
               
                   
                 Ia-248 
                 0.27 
                 17 
               
               
                   
                 Ia-250 
                 1.9 
                 — 
               
               
                   
                 Ia-252 
                 1.2 
                 — 
               
               
                   
                 Ia-253 
                 0.53 
                 — 
               
               
                   
                 Ia-254 
                 2.0 
                 — 
               
               
                   
                 Ia-255 
                 3.2 
                 — 
               
               
                   
                 Ia-256 
                 5.7 
                 — 
               
               
                   
                 Ia-257 
                 8.6 
                 — 
               
               
                   
                 Ia-258 
                 1.8 
                 — 
               
               
                   
                   
               
            
           
         
       
     
     As shown in Tables 1 to 4, the compounds of the present invention have an NPY Y5 receptor antagonistic activity. 
     Experiment 3 
     Using the membranes prepared from Y1-expression cells (human neuroblastoma, SK-N-MC) and the membranes prepared from Y2-expression cells (human neuroblastoma, SMS-KAN), the experiment was carried out in a similar way as Experiment 1 to determine the affinity for NPY Y1 receptor and NPY Y2 receptor. 
     Binding IC 50  values for NPY Y1 and NPY Y2 receptors of I-27, I-32, I-41, I-45, I-46, I-47, I-48, I-49, I-59, I-61, I-63, I-64, I-66, I-69, I-72, I-152, I-154, I-204, I-205, I-212, Ia-3, Ia-5, Ia-6, Ia-12, Ia-16, Ia-17, Ia-20, Ia-21, Ia-22, Ia-26, Ia-28, Ia-29, Ia-30, Ia-31, Ia-32, Ia-33, Ia-37, Ia-39, Ia-40, Ia-50, Ia-51, Ia-54, Ia-62, Ia-67, Ia-124, Ia-126, Ia-139, Ia-140, Ia-142, Ia-178, Ia-199 and Ia-200 were 100,000 nM or higher and each compound had a selectivity for NPY Y5 receptor. 
     Formulation Example 1 
     
       
         
           
               
             
               
                   
               
               
                 Tablets 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Compound (I-1) 
                 15 
                 mg 
               
               
                   
                 Starch 
                 15 
                 mg 
               
               
                   
                 Lactose 
                 15 
                 mg 
               
               
                   
                 Crystalline cellulose 
                 19 
                 mg 
               
               
                   
                 Polyvinyl alcohol 
                 3 
                 mg 
               
               
                   
                 Distilled water 
                 30 
                 ml 
               
               
                   
                 Calcium stearate 
                 3 
                 mg 
               
               
                   
                   
               
            
           
         
       
     
     After all of the above ingredients except for calcium stearate are uniformly mixed, the mixture is crushed and granulated, and dried to obtain a suitable size of granules. After calcium stearate is added to the granules, tablets are formed by compression molding. 
     Formulation Example 2 
     
       
         
           
               
             
               
                   
               
               
                 Capsules 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Compound (I-2) 
                 10 mg 
               
               
                   
                 Magnesium stearate 
                 10 mg 
               
               
                   
                 Lactose 
                 80 mg 
               
               
                   
                   
               
            
           
         
       
     
     After the above ingredients are mixed to prepare powders or granules, the obtained are filled in capsules. 
     Formulation Example 3 
     
       
         
           
               
             
               
                   
               
               
                 Granules 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Compound (I-3) 
                  30 g 
               
               
                   
                 Lactose 
                 265 g 
               
               
                   
                 Magnesium Stearate 
                  5 g 
               
               
                   
                   
               
            
           
         
       
     
     After the above ingredients are mixed uniformly and formed by compression molding, the obtained are crushed, granulated and sieved to prepare suitable volume of granules. 
     Industrial Applicability 
     As shown in the above Experiments, the compounds of the present invention have an NPY Y5 receptor antagonistic activity. Therefore, the compounds of the present invention are useful as an anti-obestic agent and anorectic agent.