Patent Publication Number: US-4255579-A

Title: 11-Substituted hexahydro-2,6-methano-3-benzazocines

Description:
RELATED APPLICATIONS 
     This is a continuation-in-part of my prior, copending application Ser. No. 877,166, filed Feb. 13, 1978, now U.S. Pat. No. 4,180,667 patented Dec. 25, 1979, which in turn is a continuation-in-part of my prior application Ser. No. 741,227, filed Nov. 12, 1976, now U.S. Pat. No. 4,100,164 patented July 11, 1978, which in turn is a continuation-in-part of my prior, now abandoned application Ser. No. 695,977, filed June 14, 1976, which in turn is a continuation-in-part of my prior, now abandoned application Ser. No. 576,313, filed May 12, 1975, which in turn is a continuation-in-part of my prior application Ser. No. 471,571, filed May 20, 1974, now U.S. Pat. No. 3,932,422, patented Jan. 13, 1976. 
    
    
     BACKGROUND OF THE INVENTION 
     a. Field of the Invention 
     This invention relates to 11(eq)-substituted-2,6-methano-3-benzazocines useful as analgesics and narcotic antagonists. 
     b. Description of the Prior Art 
     2,6-Methano-3-benzazocines substituted in the 11-position with a lower-alkyl group are known. (See for example Gordon et al. U.S. Pat. No. 2,924,603, patented Feb. 9, 1960). Moreover, it is known that compounds in the 5,14-endo-etheno- and ethanotetrahydrooripavine series having ketone, carbinol or lower-alkenyl groups at the 7-position thereof have unusual analgesic potency relative to morphine. [See Bentley et al., J. Am. Chem. Soc. 89, 3267-3292 (1967)]. Consequently there has been much interest in the field of analgesics in incorporating the ketone, carbinol or lower-alkenyl function present in the latter series at the 11-position of 2,6-methano-3-benzazocine-type analgesics, but all synthetic efforts in this direction have previously been unsuccessful. 
     Certain species of 8-R 2  -9-R 2  &#39;-6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(ax)-R 3  -11(eq)-CH 2  Z-2,6-methano-3-benzazocines where R 2  represents a variety of substituents, not including methoxymethoxy; Z represents various ketone functions, CH 2  COR 5 , but not including the oxime or carboxymethyloxime thereof, and where R 5  is other than cyclo-lower-alkyl or either phenyl or phenyl-lower-alkyl substituted in either case in the phenyl ring thereof by a variety of simple substituents; and where Z also represents ##STR1## but not the isomeric group ##STR2## (where R 5  is lower-alkyl and R 6  &#39; and R 8  are hydrogen or lower-alkyl), are disclosed in my Japanese Patent Appln. No. 60,111/75, filed May 20, 1975, published Dec. 25, 1975, with corresponding identical disclosure in my U.S. Pat. No. 3,932,422, patented Jan. 13, 1976. 
     SUMMARY OF THE INVENTION 
     In a composition of matter aspect, the invention relates to certain 7-R 2  &#34;-8-R 2  -9-R 2  &#39;-10-R 2  &#34;&#39;-6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(ax)-R 3  -11(eq)-CH 2  Z-2,6-methano-3-benzazocines, where Z is a ketone, carbinol or lower-alkenyl function and R 1 , R 2 , R 2  &#39;, R 2  &#34;, R 2  &#34;&#39;, R 3  and R 4  are hydrogen, lower-alkyl or other organic groups more specifically defined hereinafter, which are useful as analgesics and narcotic antagonists. 
     In a process aspect, the invention relates to a process for preparing certain 7-R 2  &#34;-8-R 2  -9-R 2  &#39;-10-R 2  &#34;&#39;-6(eq)-R 4  -1,2,3,4,5, 6-hexahydro-3-R 1  -11(ax)-R 3  -11(eq)-CH 2  Z-2,6-methano-3-benzazocines comprising heating, with formic acid in an inert organic solvent or with a benzyl-di-lower-alkylammonium formate or a tri-lower-alkylammonium formate, certain 6-R 2  &#34;-7-R 2  -8-R 2  &#39;-9-R 2  &#34;&#39;-1-R 1  -3-Y-4aα-R 3  -5α-R 4  -1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinolines. 
     DETAILED DESCRIPTION INCLUSIVE OF THE PREFERRED EMBODIMENTS 
     More specifically this invention has, as its ultimate object, the obtainment of a new class of chemical compounds, useful as analgesics and narcotic antagonists, having the formula I: ##STR3## and chemically designated 7-R 2  &#34;-8-R 2  -9-R 2  &#39;-10-R 2  &#34;&#39;-6(eq)-R 2  -1,2,3,4,5,6-hexahydro-3-R 1  -11(ax)-R 3  -11(eq)-CH 2  Z-2,6-methano-3-benzazocines. 
     The new 7-R 2  &#34;-8-R 2  -9-R 2  &#39;-10-R 2  &#34;-6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(ax)-R 3  -11(eq)-CH 2  Z-2,6-methano-3-benzazocines of formula I and other novel intermediates useful in their preparation are obtained according to my invention by novel reactions, including molecular rearrangements involving novel intermediates, according to the general reaction sequence as follows: ##STR4## 
     Thus the 7-R 2  &#34;-8-R 2  -9-R 2  &#39;-10-R 2  &#34;&#39;-6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(ax)-R 3  -11(eq)-CH 2  Z-2,6-methano-3-benzazocines having the formula I are prepared via any of several methods from the intermediate 6-R 2  &#34;-7-R 2  -8-R 2  &#39;-9-R 2  &#34;&#39;-1-R 1  -3-Y-3-R 8  -4aα-R 3  -5α-R 4  -1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinolines of formula II, which themselves are obtained from the 2-R 1  -3-(4-R 2  -3-R 2  &#34;[or 5-R 2  ]-6-R 2  &#34;&#39;-benzyl)-4-R 3  -5-R 4  -7-Y&#39;-2-azabicyclo[2.2.2]-oct-5-enes of formula IV which, in turn, are prepared according to standard procedures by reaction of a Grignard reagent derived from a 4-R 2  -3-R 2  &#39;- (or R 2  &#34;)-2-R 2  &#34;&#39;-benzyl halide of formula VI with a 3-R 3  -4-R 4  -1-R 1  -pyridinium halide of formula VII and reaction of the resulting 1-R 1  -2-(4-R 2  -3-R 2  &#39;[or R 2  &#34;]-2-R 2  &#34;&#39;-benzyl)-3-R 3  -4-R 4  -1, 2-dihydropyridine of formula VIII with a dienophile, CH 2  ═CHY&#39;. The 6-R 2  &#34;-7-R 2  -8-R 2  &#39;-9-R 2  &#34;&#39;-1-R 1  -2-Q-4aα-R 3  -5α-R 4  -1,2,3,4,4a,5,10,10a-octahydro-3,5-ethenobenzo[g]quinolines of formula IIIa are obtained along with certain compounds of formula I from the compounds of formula II where Y is COR 5  and R 8  is hydrogen. 
     In the final products and intermediates depicted in the above reaction sequences: 
     R 1  is hydrogen, lower-alkyl, lower-alkanoyl (only when R 4  is hydrogen), lower-alkenyl, lower-alkynyl, halo-lower-alkenyl, cyclo-lower-alkyl,cyclo-lower-alkyl-lower-alkyl, 2- or 3-furylmethyl, or such 2- or 3-furylmethyl substituted on the unsubstituted ring carbon atoms by from one to three methyl groups, phenyl-lower-alkyl, or phenyl-lower-alkyl substituted in the phenyl ring by from one to two members of the group consisting of halogen (including bromine, chlorine and fluorine), lower-alkyl, hydroxy, lower-alkanoyloxy, lower-alkoxy, lower-alkylmercapto, trifluoromethyl, amino, lower-alkanoylamino or a single methylenedioxy attached to adjacent carbon atoms; 
     R 2 , R 2  &#39;, R 2  &#34; and R 2  &#34;&#39; are each hydrogen, or three of them are hydrogen and the fourth is halogen (including bromine, chlorine or fluorine), lower-alkyl, hydroxy, lower-alkanoyloxy, lower-alkoxy, lower-alkylmercapto, trifluoromethyl, nitro, amino, lower-alkanoylamino, lower-alkoxycarbonylamino or phenyl, or two of the adjacent such groups together are methylenedioxy; 
     R 3  is hydrogen or lower-alkyl; 
     R 4  is hydrogen, lower-alkyl, lower-alkoxy-lower-alkyl, hydroxy-lower-alkyl, lower-alkylthio-lower-alkyl, lower-alkylsulfinyl-lower-alkyl, phenylthio-lower-alkyl, phenylsulfinyl-lower-alkyl, lower-alkenyl or halo-lower-alkyl, or R 3  and R 4  together are divalent lower-alkylene, --(CH 2 ) n  --, where n is one of the integers 3 or 4; 
     Z is one of the groups ##STR5## or the ethylene glycol ketal thereof, ##STR6## or a group of the formula: ##STR7## 
     R 5  and R 6  are the same or different hydrogen, lower-alkyl, cyclo-lower-alkyl-lower-alkyl, phenyl or phenyl-lower-alkyl; 
     R 7  is hydrogen, lower-alkanoyl, benzoyl, or benzoyl substituted by from one to three members of the group consisting of lower-alkyl, lower-alkoxy, hydroxy, halo (including chlorine, bromine and fluorine) or trifluoromethyl; 
     R 8  is hydrogen or lower-alkyl; 
     Y is carboxy, cyano, carbo-lower-alkoxy, COR 5 , COO-lower-alkylene-cyclo-lower-alkyl, COO-lower-alkylene-phenyl, or a group of the formula: ##STR8## 
     Y&#39; is carboxy, cyano, carbo-lower-alkoxy, COO-lower-alkylene-cyclo-lower-alkyl, COO-lower-alkylene-phenyl or lower-alkanoyl; and Hal is halogen. 
     Also within the purview of the invention are compounds of the formula I where R 1 , R 3  and R 4  are each lower-alkyl; R 2  is hydrogen, hydroxy or methoxymethoxy, R 2  being hydroxy only when Z has the definitions (b), (c), (d) or (e) below, and R 2  being methoxymethoxy only when Z has the definition (a) below; R 2  &#39;, R 2  &#34; and R 2  &#34;&#39; are each hydrogen; and Z is either (a) CH 2  COR 5  where R 5  is lower-alkyl (b) the oxime of O-carboxymethyloxime (═NOCH 2  COOH) of a compound where Z is CH 2  COR 5 , where R 5  is lower-alkyl; (c) CH 2  COR 5 , where R 5  is cyclo-lower-alkyl; (d) CH 2  COR 5 , where R 5  is either phenyl or phenyl-lower-alkyl substituted in either case in the phenyl ring by from one to two members of the group consisting of lower-alkyl, lower-alkoxy, lower-alkylmercapto, trifluoromethyl or methylenedioxy attached to adjacent carbon atoms; or (e) the group ##STR9## where R 5  is lower-alkyl, R 6  &#39; is hydrogen or lower-alkyl and R 8  is hydrogen or lower-alkyl. 
     As used herein, the terms lower-alkyl or lower-alkoxy mean saturated, acyclic groups which may be straight or branched containing from one to about seven carbon atoms as exemplified by methyl, ethyl, propyl, isopropyl, butyl, nonadjacent t-butyl, methoxy, ethoxy, propoxy, isopropoxy, or t-butoxy. 
     As used herein, the terms lower-alkenyl, halo-lower-alkenyl and lower-alkynyl represent monovalent groups of from three to seven carbon atoms containing one double or triple bond as illustrated, for example, by 1-propenyl, 2-butenyl, 4-pentenyl, 3-methyl-2-butenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 2-propynyl, 2-butynyl, 4-pentynyl, 2-hexynyl, and the like. The term halo-lower-alkenyl includes, for example, 2-chloroethenyl, 2-bromoethenyl, 3,3-dichloro-2-propenyl, 1-bromo-2-methylpropenyl, and the like. 
     As used herein, the term cyclo-lower-alkyl alkyl means saturated carbocyclic groups containing from three to seven ring carbon atoms as illustrated, for example, by cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, 2-methylcyclobutyl, 4-ethylcyclohexyl, and the like. 
     As used herein, the term lower-alkanoyl means such groups derived from saturated, aliphatic monocarboxylic acids having from one to four carbon atoms, as illustrated, for example, by formyl, acetyl, propionyl, butyryl, isobutyryl, and the like. 
     As used herein, the term lower-alkylene means a saturated, divalent radical, which can be straight or branched, and having from one to four carbon atoms, as illustrated, for example, by methylene [--CH 2  --], 1,2-ethylene [--CH 2  CH 2  --], 1,3-propylene [--CH 2  CH 2  CH 2  --], 1,2-(1-methylethylene)[--CH(CH 3 )CH 2  --], 1,4-butylene [--CH 2  CH 2  CH 2  CH 2  --], and the like. 
     As determined by standard pharmacological test procedures to be described hereinafter, the compounds of formula I have been found to have useful analgesic activity, and as indicated by pharmacological test data presented hereinafter, some compounds of formula I have also been found to have useful narcotic antagonist activity. The compounds of formula I are thus useful as analgesic agents and narcotic antagonists. 
     Preferred compounds within the ambit of formula I are those where Z is the group CH 2  COR 5  where R 5  is lower-alkyl, cyclo-lower-alkyl-lower-alkyl or phenyl-lower-alkyl, and R 1 , R 2 , R 2  &#39;, R 2  &#34;, R 2  &#34;&#39;, R 3  and R 4  have the meanings given above, and particularly preferred compounds are those of the latter type where R 1 , R 3  and R 4  are each lower-alkyl; R 2  is hydroxy; and R 2  &#39;, R 2  &#34; and R 2  &#34;&#39; are each hydrogen. 
     In accordance with the above general description, the 7-R 2  &#34;-8-R 2  -9-R 2  &#39;-10-R 2  &#34;&#39;-6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(ax)-R 3  -11(eq)-CH 2  Z-2,6-methano-3-benzazocines of formula I where Z is ##STR10## and R 1 , R 2 , R 2  &#39;, R 2  &#34;, R 2  &#34;&#39;, R 3 , R 4 , R 5 , R 6  and R 8  have the meanings given above are prepared by heating, with formic acid in an organic solvent, for example toluene, xylene or mesitylene, or with a benzyl-di-lower-alkylammonium or a tri-lower-alkylammonium formate at a temperature in the range from 120°-150° C., a 6-R 2  &#34;-7-R 2  -8-R 2  &#39;-9-R 2  &#34;&#39;-1-R 1  -3-Y-3-R 8  -4aα-R 3  -5α-R 4  -1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline of formula II where R 8  is hydrogen and Y is either COR 5  (to give the compounds of formula I where Z is CH 2  COR 5 ) or the group: ##STR11## where R 7  is hydrogen (to give the compounds of formula I where Z is ##STR12## A preferred solvent is mesitylene. The compounds of formula II where Y is COR 5  or the group ##STR13## where R 7  is hydrogen are thus intermediates for preparing the compounds of formula I where Z is, respectively, the groups --CH 2  COR 5  or ##STR14## 
     The compounds of formula I where R 5  is benzyl (or benzyl substituted in the phenyl ring thereof by the substituents enumerated above) and R 1 , R 2 , R 2  &#39;, R 2  &#34;, R 2  &#34;&#39;, R 3 , R 4 , R 6  and R 8  have the meanings given above can also be prepared by reaction of a lower-alkyl β-[7-R 2  &#34;-8-R 2  -9-R 2  &#39;-10-R 2  &#34;&#39;-6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(ax)-R 3  -2,6-methano-3-benzazocin-11(eq)-yl]propionate of formula Ia with an alkali metal salt of phenylacetic acid (or a phenylacetic acid substituted in the phenyl ring thereof), the latter prepared by reaction of the desired phenylacetic acid with two molar equivalents of an alkali metal amide, followed by hydrolysis and simultaneous decarboxylation of the resulting condensation product. The method is illustrated by the reaction using unsubstituted phenylacetic acid: ##STR15## where Alk represents lower-alkyl. The esters of formula Ia and the method for their preparation are disclosed in Lewis and Michne U.S. Pat. No. 4,119,628, patented Oct. 10, 1978, and c.i.p. thereof Ser. No. 878,308, filed Feb. 16, 1978, which applications are more fully described below, the disclosures of which are incorporated herein by reference. 
     The oximes or O-carboxymethyloximes of the compounds of formula I where Z is ##STR16## are prepared by reacting the latter with hydroxylamine or O-carboxymethylhydroxylamine in an inert organic solvent, for example a lower-alkanol. The reaction is carried out by heating the reactants in the solvent at the reflux temperature of the latter. 
     The compounds of formula I where Z is ##STR17## where R 8  is lower-alkyl, are prepared by treatment of the compounds of formula IIB, where R 8  is hydrogen and Y is a proton activating group, i.e. an ester or keto (COR 5 ) group, with a strong base, for example a lithium di-lower-alkylamide, a preferred base being lithium diisopropylamide, and reaction of the resulting lithium salt with a lower-alkyl ester of a strong mineral acid, for example a lower-alkyl halide or a di-lower-alkyl sulfate. The ester or keto group Y in the compounds of formula IIA thus obtained can then be converted to other groups, for example ##STR18## before conversion of the latter to the compounds of formula I where Z is ##STR19## and R 8  is lower-alkyl by heating the compounds of formula II where R 8  is lower-alkyl with formic acid in an organic solvent or with a benzyl-di-lower-alkylammonium or tri-lower-alkylammonium formate as described above. 
     As indicated in the above reaction sequence, alkylation of the compounds of formula IIB via the lithium salt results in epimerization of the Y group. It had been previously thought that the group Y in the compounds of formula IIB as obtained by cyclization of the compounds of formula IV possesses the β-configuration, i.e. the group Y is cis to the 2,5-methano bridge (vide infra), and such steric configuration of the group Y is disclosed in Sterling Drug Inc.-owned Japanese Provisional Patent Publication No. 160,275, published Dec. 26, 1976 from Japanese Patent Appln. 60,111/75, filed May 20, 1975 as well as in U.S. Pat. No. 3,932,422, patented Jan. 13, 1976 on application Ser. No. 471,571, filed May 20, 1974 and on which Japanese Appln. No. 60,111/75 was based. However, since the time of preparation and filing of the Japanese application on which the patent publication is based, some uncertainty has developed over whether the group Y has the α- or β-configuration. In any event, alkylation of the compounds of formula IIB via the lithium salt results in epimerization of the group Y, and in fact, the compounds of formula IIA where R 8  is hydrogen and the Y group is in either the α- or the β-configuration can be prepared from the respective β-Y or α-Y compounds by treatment first with a strong base and then with acid. In view of the fact then that either of the groups Y and R 8  in the compounds of formulas IIA and IIB, respectively, can occupy either the α- or the β-configuration, the compounds of formulas IIA and IIB can be generally represented by the formula: ##STR20## where R 8  is hydrogen or lower-alkyl. 
     Insofar as the structures of the 2,6-methano-3-benzazocines of formula I are concerned, the question of the steric configuration at the 3-position of the compounds of formula II is moot, because the asymmetry at the 3-position is destroyed on conversion of the compounds of formula II to the compounds of formula I, and the compounds of formula II having both possible steric configurations at the 3-position are fully operable for the preparation of the compounds of formula I. 
     Insofar as the steric configuration of the group Q in the compounds of formula IIIa is concerned, a study of molecular models of hypothetical reaction intermediates indicates that the group Q probably has the β-configuration, i.e. Q is cis to the 3,5-etheno bridge, but the configuration has not been rigorously established. 
     The compounds of formula I where Z is the group: ##STR21## where R 7  is hydrogen and R 5 , R 6  and R 8  have the meanings given above are prepared from the corresponding compounds where Z is the group ##STR22## by hydroxylation of the latter, for example with concentrated sulfuric acid and hydrolysis of the resulting hydrogen sulfate ester. The compounds of formula I where Z is the group ##STR23## are thus intermediates for the carbinols of formula I. 
     The compounds of formula I where Z is the group ##STR24## where each of R 6  and R 7  is hydrogen and R 5  and R 8  have the meanings given above are prepared by selective reduction of the corresponding compounds where Z is ##STR25## When R 5  is hydrogen the selective reduction is carried out with an alkali metal aluminum hydride in an inert organic solvent such as dioxane, tetrahydrofuran or diethyl ether at temperatures in the range from about 0° C. to 100° C. When R 5  is lower-alkyl, cyclo-lower-alkyl-lower-alkyl, phenyl or phenyl-lower-alkyl, the reduction is carried out with an alkali metal borohydride in an inert organic solvent, for example lower-alkanols, such as methanol, ethanol or isopropanol. 
     The compounds of formula I where Z is ##STR26## R 5  and R 6  are each lower-alkyl, cyclo-lower-alkyl, cyclo-lower-alkyl-lower-alkyl, phenyl, phenyl-lower-alkyl, or substituted-phenyl or phenyl-lower-alkyl, R 7  is hydrogen and R 8  is hydrogen or lower-alkyl are prepared by reaction of the corresponding compounds where Z is ##STR27## where R 5  is lower-alkyl, cyclo-lower-alkyl, cyclo-lower-alkyl-lower-alkyl, phenyl, phenyl-lower-alkyl or substituted-phenyl or phenyl-lower-alkyl with one molar equivalent of an appropriate organo lithium, R 6  Li, where R 6  has the meanings given above. The reaction is carried out in an inert organic solvent such as benzene or toluene. In this manner compounds where R 5  and R 6  are either the same or different lower-alkyl, cyclo-lower-alkyl, cyclo-lower-alkyl-lower-alkyl, phenyl, phenyl-lower-alkyl, or substituted phenyl or phenyl-lower-alkyl groups can be prepared depending upon the identity of the R 5  group and the choice of the particular organo lithium. 
     The compounds of formula I where Z is ##STR28## are prepared from the corresponding compounds where Z is ##STR29## by use of the Wittig reaction which comprises reacting the latter with a lower-alkylidene triphenylphosphorane, the latter prepared by reaction of a lower-alkyl triphenyl phosphonium halide with an alkali metal hydride, in an inert organic solvent, for example dimethylsulfoxide, as illustrated by the reaction sequence where Bz represents the 11-(hexahydro-2,6-methano-3-benzazocinyl) portion of formula I: ##STR30## 
     The compounds of formula I where Z is ##STR31## where R 5 , R 6  &#39; and R 8  have the meanings given above are prepared by dehydration, under acid conditions, of the corresponding carbinol where Z is the group ##STR32## where R 6  is lower-alkyl, the compounds of formula I where R 6  is methylene (═CH 2 ) being of course produced when R 6  is methyl. Suitable acid media for dehydration are sulfuric acid or acetic acid in combination with a strong organic or inorganic acid, for example methanesulfonic acid. 
     Neither of the two above-described processes for preparing the compounds of formula I where Z is ##STR33## is disclosed in my above-identified Japanese Patent Appln. No. 60,111/76 or U.S. Pat. No. 3,932,422. In fact the process disclosed in those prior publications for preparing compounds of formula I where Z is ##STR34## is inoperative for the preparation of the compounds where Z is the group ##STR35## 
     The compounds of formula I where Z is ##STR36## R 5  and R 6  are each hydrogen or the same or different lower-alkyl, cyclo-lower-alkyl, cyclo-lower-alkyl-lower-alkyl, phenyl, phenyl-lower-alkyl or substituted phenyl or phenyl-lower-alkyl, R 8  has the meanings given above, and R 7  is lower-alkanoyl, benzoyl or substituted-benzoyl are prepared by esterification of the corresponding compounds where R 7  is hydrogen, for example with an appropriate acid halide, anhydride or other acylating agent. The reaction is advantageously carried out using an appropriate acid halide in a pyridine solvent which serves as an acid-acceptor to take up the hydrogen halide split out during the course of the reaction. 
     The compounds of formula I where R 1  is lower-alkenyl, lower-alkynyl, halo-lower-alkenyl or 2- or 3-furylmethyl (or such 2- or 3-furylmethyl substituted by from one to three methyl groups) are advantageously prepared from the corresponding compounds where R 1  is hydrogen by reaction of the latter with an appropriate lower-alkenyl halide, lower-alkynyl halide or halo-lower-alkenyl halide, as the case may be, in an inert organic solvent, for example a lower-alkanol, acetone or dimethylformamide (hereinafter designated DMF), in the presence of an acid-acceptor, for example an alkali metal carbonate or bicarbonate. A preferred solvent is DMF. 
     The compounds of formula I where R 2 , R 2  &#39;, R 2  &#34; or R 2  &#34;&#39; is lower-alkanoyloxy are advantageously prepared from the corresponding compounds where R 2 , R 2  &#39;, R 2  &#34; or R 2  &#34;&#39; is hydroxy by esterification with an appropriate lower-alkanoyl halide in the presence of pyridine. 
     The compounds of formula I where R 2 , R 2  &#39;, R 2  &#34; or R 2  &#34;&#39; is amino are prepared by hydrolysis of the corresponding compounds where R 2 , R 2  &#39;, R 2  &#34; or R 2  &#34;&#39; is lower-alkanoylamino or lower-alkoxycarbonylamino by heating the latter in aqueous alkali. 
     Alternatively, the compounds of formula I where R 2 , R 2  &#39;, R 2  &#34; or R 2  &#34;&#39; is amino are prepared by reaction of the compounds of formula I where Z is ##STR37## and R 1  is hydrogen with nitric acid in glacial acetic acid. The reaction is carried out at temperatures from 0° to 5° C. The resulting nitro compound is then alkylated as desired in the manner described above to prepare compounds where R 1  has the other various meanings given above, and in a final step, the nitro group is reduced to the corresponding amino group by either catalytic means, for example with hydrogen over palladium-on-charcoal, or by chemical means, for example by iron and hydrochloric acid or by tin and hydrochloric acid. 
     The compounds of formula I where R 2  is methoxymethoxy are prepared by reaction of the corresponding compounds where R 2  is hydroxy with dimethoxymethane in the presence of a catalytic amount of a strong acid and in an inert organic solvent. The reaction is carried out by refluxing a solution of the reactants in the chosen solvent, for example chloroform, methylene dichloride, ethylene dichloride and the like, under a Soxhlet extractor containing molecular sieves having a pore size sufficient to trap and hold molecules of methanol. 
     In this way the methanol produced in the reversible reaction is removed from the reaction mixture as it is formed, and the reaction proceeds to completion. It has been found that 4A molecular sieves have a porosity of the proper size for this purpose. 
     The compounds of formula I where R 2  is methoxymethoxy are particularly useful as intermediates for preparing the corresponding compounds where R 2  is hydroxy and which contain acid sensitive groups elsewhere in the molecule, for example compounds where Z is CH 2  COR 5  where R 5  is cyclopropyl, since the methoxymethoxy group is readily cleaved under mild acid conditions. 
     As indicated in the reaction sequence shown above, the 6-R 2  &#34;-7-R 2  -8-R 2  &#39;-9-R 2  &#34;&#39;-1-R 1  -2-Q-4aα-R 3  -5α-R 4  -1,2,3,4,4a,5,10,  10a-octahydro-3,5l -ethenobenzo[g]quinolines of formula IIIa where Q is H 2 , CH-lower-alkyl, CH-cyclo-lower-alkyl, CH-cyclo-lower-alkyl-lower-alkyl, CH-phenyl, CH-lower-alkylphenyl, or substituted CH-phenyl or CH-lower-alkylphenyl are produced along with the compounds of formula I (where Z is --CH 2  COR 5 ) when the compounds of formula II where Y is COR 5  and R 8  is hydrogen are heated with formic acid in an organic solvent or with a benzyl-di-lower-alkylammonium formate or a tri-lower-alkylammonium formate as described above. When the benzazocines of formula I are the desired product, it is preferred to carry out the reaction in mesitylene using a concentration of 0.05 molar in starting material of formula II and 1.0 molar in formic acid. This mixture gives a reaction temperature at reflux of about 120° C. and affords the benzazocines of formfula I and the benzo[g]quinolines of formula IIIa in a ratio of from 2:1 to 3:1. By progressively decreasing the formic acid concentration, successively higher boiling mixtures are produced, which result in production of progressively increased relative amounts of the benzo[g]quinolines. Thus at formic acid concentration of 0.5 molar and 0.15 molar (0.05 molar in starting material), the benzo[g]quinolines and benzazocines are produced in ratios of about 2:1 and 7:1, respectively. Similarly, by using a ratio of 1 mole of starting material to 5 moles of, respectively, benzyldimethylammonium formate or trimethylammonium formate or triethylammonium formate and heating the mixture (in the absence of any organic solvent) at 150° C. for about fifteen minutes, a mixture of benzo[g]quinoline and benzazocine is produced in ratios of 10:1, 3:1 and 20:1, respectively. 
     The two transformations thus take place simultaneously under the given conditions and are best seen by reference to the reaction sequence: ##STR38## where R 1 , R 2 , R 2  &#39;, R 2  &#34;, R 2  &#39;&#34;, R 3 , R 4 , R 5 , R 8  and Q have the meanings given above. It will be seen from the above that the compounds of formula I result by rupture, under the reaction conditions, of bond (b) in the compounds of formula II, whereas the compounds of formula IIIa result when bond (a) is broken, followed by ring closure between the nitrogen atom and the carbonyl group of the COR 5  moiety. 
     An alternative process for preparing the compounds of formula I which does not result in production of compounds of formula IIIa is the process described in T. R. Lewis and W. F. Michne U.S. Pat. No. 4,119,628, the disclosure of which is incorporated herein by reference, which is useful for the preparation of the compounds of formula I when Z is ##STR39## where R 8  is hydrogen and R 5  has all the meanings given above. According to the Lewis and Michne process, a lower-alkyl 1-R 1  -3-R 5  CO-4aα-R 3  -5α-R 4  -6-R 2  &#34;-7-R 2  -8-R 2  &#39;-9-R 2  &#34;&#39; 1,2,3,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline-3-carboxylate having the formula IX is heated with formic acid in an inert organic solvent, for example toluene, xylene, or mesitylene, or with a benzyl-di-lower-alkylammonium formate or a tri-lower-alkylammonium formate using the same conditions as described above for the conversion of the compounds of formula II to the compounds of formula I. The reaction results in simultaneous ring opening between the carbon atoms at the 2-and 3-positions of the compounds of formula IX and hydrolysis and decarboxylation of the 3-cabo-lower-alkoxy group, COOAlk, according to the following reaction: ##STR40## where R 1 , R 2 , R 2  &#39;, R 2  &#34;, R 2  &#34;&#39;, R 3 , R 4  and R 5  have the meanings given above, and Alk represnts lower-alkyl. 
     The compounds of formula IX and the methods for their preparation are described in the above-identified Lewis and Michne U.S. Pat. No. 4,119,628. 
     The compounds of formulas II, IIA, IIB, IIIa and IV, and methods for their preparation are described in detail in U.S. Pat. Nos. 3,932,422 and 4,100,164 and in the parent application hereof, Ser. No. 877,166, now U.S. Pat. No. 4,180,667 the disclosures of all of which are incorporated herein by reference. 
     The compounds of formula I where R 1  is benzyl can be catalytically debenzylated to give the corresponding compounds where R 1  is hydrogen. The latter can then be realkylated with an appropriate alkylating agent to give other different compounds where R 1  has the meanings, other than hydrogen, given above. Reduction is carried out in an inert organic solvent, for example ethanol, isopropanol, and the like, and at pressures from 40 to 100 p.s.i.g. A preferred catalyst is palladium-on-charcoal. The alkylation of the compounds of formula I where R 1  is hydrogen is carried out in an inert organic solvent, for example acetone, ethanol or DMF, and in the presence of an acid-acceptor, for example alkali metal carbonates or bicarbonates. 
     Due to the presence of a basic amino grouping, the free base forms represented by formula I react with organic and inorganic acids to form acid-addition salts. The acid-addition salt forms are prepared from any organic or inorganic acid. They are obtained in conventional fashion, for instance either by direct mixing of the base with the acid or, when this is not appropriate, by dissolving either or both of the base and the acid separately in water or an organic solvent and mixing the two solutions, or by dissolving both the base and the acid together in a solvent. The resulting acid-addition salt is isolated by filtration, if it is insoluble in the reaction medium, or by evaporation of the reaction medium to leave the acid-addition salt as a residue. The acid moieties or anions in these salt forms are in themselves neither novel nor critical and therefore can be any acid anion or acid-like substance capable of salt formation with the base. 
     Representative acids for the formation of the acid-addition salts include formic acid, acetic acid, isobutyric acid, alpha-mercaptopropionic acid, trifluoroacetic acid, malic acid, fumaric acid, succinic acid, succinamic acid, tannic acid, glutamic acid, tartaric acid, oxalic acid, pyromucic acid, citric acid, lactic acid, glycolic acid, glyconic acid, saccharic acid, ascorbic acid, penicillin, benzoic acid, phthalic acid, salicylic acid, 3,5-dddnitrobenzoic acid, anthranilic acid, cholic acid, 2-pyridinecarboxylic acid, pamoic acid, 3-hydroxy-2-naphthoic acid, picric acid, quinic acid, tropic acid, 3-indoleacetic acid, barbituric acid, sulfamic acid, methanesulfonic acid, ethanesulfonic acid, isethionic acid, benzenesulfonic acid, p-toluenesulfonic acid, butylarsonic acid, methanephosphonic acid, acidic resins, hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydriodic acid, perchloric acid, nitric acid, sulfuric acid, phosphoric acid, arsenic acid, and the like. 
     All of the acid-addition salts are useful as sources of the free base forms, by reaction with an inorganic base. It will thus be appreciated that if one or more of the characteristics, such as solubility, molecular weight, physical appearance, toxicity, or the like of a given base or acid-addition salt thereof render that form unsuitable for the purpose at hand, it can be readily converted to another, more suitable form. For pharmaceutical purposes, acid-addition salts of relatively non-toxic, pharmaceutically-acceptable acids, for example hydrochloric acid, lactic acid, tartaric acid, and the like, are of course employed. 
     The compounds of this invention can exist in stereochemically isomeric forms, that is, optical isomers and geometric isomers, and all such isomers are considered to be within the purview of the invention. If desired, the isolation or the production of a particular stereochemical form can be accomplished by application of the general principles known in the prior art. In the nomenclature employed for the compounds of formula I herein, &#34;ax&#34; stands for axial and &#34;eq&#34; for equatorial, and the configurations are given with reference to the hydroaromatic ring. Thus, the 6(eq), 11(ax) compounds of formula I are in the cis configuration, whereas the 6(eq), 11(eq) compounds are in the trans configuration. 
     In standard pharmacological test procedures, the compounds of formula I and the acid-addition salts thereof have been found useful as depressants of the central nervous system, and more particularly have been found useful as analgesics and as antagonists of strong analgesics such as phenazocine, meperidine and morphine. 
     The compounds of formula I can be administered in the same manner as known analgesics and antagonists of strong analgesics, i.e. parenterally or orally in any of the conventional pharmaceutical forms, as for instance solutions, suspensions, tablets, capsules, and the like. 
     As described above, and as will be seen hereinbelow, many of the species of formula I are readily interconvertible by simple and well-known reactions such as reduction, oxidation, hydrolysis, esterification, etherification, and the like, so that they are also useful as intermediates for each other. 
     The useful properties of the compounds of this invention were demonstrated by standard pharmacological procedures readily carried out by technicians having ordinary skill in pharmacological test procedures, so that the actual determination of the numerical biological data definitive for a particular test compound can be ascertained without the need for any extensive experimentation. 
     The test procedures used to determine the analgesic and analgesic antagonist activities of the compounds of the invention have been described in detail in the prior art and are as follows: the acetylcholine-induced abdominal constriction test, which is a primary analgesic screening test designed to measure the ability of a test agent to suppress acetylchloline-induced abdominal constriction in mice, described by Collier et al., Brit. J. Pharmacol. Chemotherap. 32, 295 (1968); a modification of the ant-bradykinin test, which is also a primary analgesic screening procedure, described by Berkowitz et al., J. Pharmacol. Exp. Therap. 177, 500-508 (1971), Blane et al., J. Pharm. Pharmacol. 19, 367-373 (1967), Botha et al., Eur. J. Pharmacol. 6, 312-321 (1969) and Deffenu et al., J. Pharm. Pharmacol. 18, 135 (1966); the phenyl-p-quinone-induced writhing test, also a primary analgesic screening test, designed to measure the ability of a test agent to prevent phenyl-p-quinone-induced writhing in mice, described by Pearl and Harris, J. Pharmacol. Exptl. Therap. 154, 319-323 (1966); the rat tail flick radiant thermal heat analgesic (agonist) test described by D&#39;Amour and Smith, J. Pharmacol. Exptl. Therap. 72, 74 (1941) as modified by Bass and VanderBrook, J. Am. Pharm. Assoc. Sci. Ed. 41, 569 (1956); and the phenazocine antagonist test, which is designed to measure the ability of a test agent to antagonize the effect of phenazocine in the above-indicated rat tail flick response test, described by Harris and Pierson, J. Pharmacol. Exptl. Therap. 143, 141 (1964). 
     The structures of the compounds of this invention were established by the modes of synthesis, by elementary analyses and by ultraviolet, infrared and nuclear magnetic resonance spectra. The course of reactions and homogeneity of the products were ascertained by thin layer chromatography. 
     The manner and process of making and using the invention, and the best mode contemplated by the inventor of carrying out this invention, will now be described so as to enable any person skilled in the art to which it pertains to make and use the same. The melting points are uncorrected unless noted otherwise. 
     In the various tables accompanying the following examples, the weights of the principal, organic starting materials (S.M.) and products (Prod.) are given in grams in the appropriate columns headed &#34;Wt.S.M./Wt.Prod.&#34;, and the melting points of the final products, together with the solvent of recrystallization, are given in the last column. 
     Where weights of only one of several reactants are given, the weights of such other reactants can be calculated on a proportionate molar basis from the amounts used in the example referred to for the preparative procedure employed. In some instances, the products were neither characterized nor purified, either by distillation or recrystallization, but rather were used directly in the next step as isolated from the reaction mixture. 
     The particular form of the starting material or product, whether base or salt, is specified along with the weights by use of designations such as &#34;base&#34;, &#34;HCl&#34;, &#34;HBr&#34;, etc. to indicate that the weights are given, respectively, for the free base or the hydrochloride, hydrobromide, etc. salts. 
    
    
     EXAMPLE 1 
     A. A solution of 11 g. (0.039 mole) of 1-methyl-3-acetyl-5α-ethyl-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline hydrochloride in 20 ml. of a solution prepared by adding 89 ml. of trimethylamine to 94 ml. of formic acid was stirred and heated under reflux for about 15 minutes. The mixture was allowed to cool, diluted with 100 ml. of water and washed with 50 ml. of diethyl ether. The aqueous layer was basified with 15 ml. of concentrated ammonium hydroxide and extracted twice with diethyl ether. The combined organic extracts, on washing once with water, drying and concentration to dryness, afforded 10 g. of a solid residue which was dissolved in about 30 ml. of absolute ethanol, the solution acidified with 13 ml. of ethereal hydrogen chloride, and diluted to 250 ml. with additional ether. The solid which separated was collected, washed, and set aside. The filtrate was washed with dilute ammonium hydroxide, dried, filtered and taken to dryness to give 3.1 g. of residue which was dissolved in diethyl ether and acidified with ethereal hydrogen chloride. The gummy, semi-crystalline material which separated was recrystallized from ethanol/ether to give 0.8 g. of 6(eq)-ethyl-1,2,3,4,5,6-hexahydro-3-methyl-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine hydrochloride, m.p. 192°-196° C. 
     B. An alternative method for the preparation of the compounds of formula I from the compounds of formula II is illustrated by the following procedure: 
     A mixture of 10.0 g. (0.03 mole) of 1-methyl-3-acetyl-5α-ethyl-7-hydroxy-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline in 675 ml. of mesitylene and 25 ml. of formic acid was stirred and refluxed for about eight hours while adding additional formic acid from time to time in order to maintain the pot temperature at 117°-119° C. The mixture was then cooled, extracted with dilute hydrochloric acid and the acid extracts washed first with diethyl ether, then basified with ammonium hydroxide and extracted once again with ethyl acetate. The organic extracts, on washing with brine, drying and evaporation to dryness, afforded 8.4 g. of solid which was recrystallized from ethyl acetate to give 3.7 g. of 6(eq)-ethyl-1,2,3,4,5,6-hexahydro-3-methyl-8-hydroxy-11(eq)-(3-oxobutyl-2,6-methano-3-benzazocine, m.p. 190°-192° C. 
     Following a procedure similar to that described in Example 1 A or B above, using an appropriate 7-R 2  -1-R 1  -3-COR 5  -4aα-R 3  -5α-R 4  -1,2,3,4,4a,5,10,10a-octahydro-2,5methanobenzo[g]quinoline of formula II, the following 8-R 2  -6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(ax)-R 3  -11(eq)-(oxo-lower-alkyl)-2,6-methano-3-benzazocines of formula I in Table 1 a are prepared, where R 2  &#39;, R 2  &#34;, R 2  &#39;&#34; and R 8  in each case are hydrogen. The particular procedure used, that of Example 1 A or 1 B, is indicated by the letter designation (A) or (B), respectively, below the Example number. Unless noted otherwise, products were isolated as, and melting points recorded for, the free base form. 
     
                                           TABLE 1a                                
__________________________________________________________________________
Example                                                                   
      R.sub.1 /CH.sub.2 Z                                                 
                     R.sub.2                                              
                         R.sub.3 /R.sub.4                                 
                             Wt.II/Wt.I                                   
                                   m.p. (° C.)/Solv.               
__________________________________________________________________________
1C    CH.sub.3       H   CH.sub.3                                         
                             10 (base)                                    
                                   207-208 (a)                            
(A)   CH.sub.2 CH.sub.2 COCH.sub.3                                        
                         C.sub.2 H.sub.5                                  
                             2.1 (salt)                                   
                                   ethanol/ether                          
                             (a)                                          
1D    C.sub.3 H.sub.5 --CH.sub.2 (c)                                      
                     H   H   16 (base)                                    
                                   206-208 (b)                            
(B)   CH.sub.2 CH.sub.2 COCH.sub.3                                        
                         C.sub.2 H.sub.5                                  
                             7.8 (base)                                   
                                   ethanol/ether                          
1E    C.sub.6 H.sub.5 CH.sub.2                                            
                     CH.sub.3 O                                           
                         H   18.8 (base)                                  
                                   104-106                                
(B)   CH.sub.2 CH.sub.2 COCH.sub.3                                        
                         CH.sub.3                                         
                             7.2 (base)                                   
                                   ethanol                                
1F    C.sub.6 H.sub.5 CH.sub.2                                            
                     CH.sub.3 O                                           
                         H   39 (base)                                    
                                   122-125                                
(B)   CH.sub.2 CH.sub.2 COCH.sub.3                                        
                         C.sub.2 H.sub.5                                  
                             10.6 (base)                                  
                                   ethanol                                
1G    C.sub.6 H.sub.5 CH.sub.2                                            
                     CH.sub.3 O                                           
                         CH.sub.3                                         
                             19.5 (base)                                  
                                   132-135                                
(B)   CH.sub.2 CH.sub.2 COCH.sub.3                                        
                         CH.sub.3                                         
                             11.5 (base)                                  
                                   ethanol                                
1H    CH.sub.3       CH.sub.3 O                                           
                         H   4.9 (base)                                   
                                   132-134                                
(B)   CH.sub.2 CH.sub.2 COC.sub.5 H.sub.11                                
                         CH.sub.3                                         
                             3.3 (salt)                                   
                                   ethanol/ether                          
                             (d)                                          
1J    C.sub.6 H.sub.5 CH.sub.2                                            
                     H   CH.sub.3                                         
                             55.3 (base)                                  
                                   229-232                                
(B)   CH.sub.2 CH.sub.2 COCH.sub.3                                        
                         CH.sub.3                                         
                             37.7 (HCl)                                   
                                   ethanol/ether                          
1K    C.sub.6 H.sub.5 CH.sub.2                                            
                     CH.sub.3 O                                           
                         H   18.7 (base)                                  
                                   244-246                                
(B)   CH.sub.2 CH.sub.2 COC(CH.sub.3).sub.3                               
                         CH.sub.3                                         
                             15.3 (HCl)                                   
                                   ethanol/ether                          
1L    C.sub.6 H.sub.5 CH.sub.2                                            
                     CH.sub.3 O                                           
                         CH.sub.3                                         
                             39.2 (base)                                  
                                   248-255                                
(B)   CH.sub.2 CH.sub.2 COC(CH.sub.3).sub.3                               
                         CH.sub.3                                         
                             33.0 (HCl)                                   
                                   ethanol/ether                          
1M    CH.sub.3       CH.sub.3 O                                           
                         CH.sub.3                                         
                             base  217-221                                
(B)   CH.sub.2 CH.sub.2 COCH.sub.2 CH.sub.3                               
                         CH.sub.3                                         
                             salt (e)                                     
                                   ethanol/ether                          
1N    CH.sub.3       CH.sub.3 O                                           
                         CH.sub.3                                         
                             base  176-179                                
(B)   CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.2 CH.sub.3                       
                         CH.sub.3                                         
                             salt (e)                                     
                                   acetone/ether                          
1P    C.sub.3 H.sub.5 --CH.sub.2 (c)                                      
                     CH.sub.3 O                                           
                         CH.sub.3                                         
                             base  219-220                                
(B)   CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.3 CH.sub.3                       
                         CH.sub.3                                         
                             HCl   acetone                                
1Q    CH.sub.3       CH.sub.3 O                                           
                         H   base  183.5-185                              
(B)   CH.sub. 2 CH.sub.2 CO(CH.sub.2).sub.3 CH.sub.3                      
                         CH.sub.3                                         
                             salt (f)                                     
                                   acetone                                
1R    C.sub.6 H.sub.5 CH.sub.2                                            
                     CH.sub.3 O                                           
                         CH.sub.3                                         
                             base  226-228                                
(B)   CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.3 CH.sub.3                       
                         CH.sub.3                                         
                             HCl   acetone                                
1S    CH.sub.3       CH.sub.3 O                                           
                         CH.sub.3                                         
                             base  146-148                                
      CH.sub.2 CH.sub.2 COCH.sub.2 CH(CH.sub.3).sub.2                     
                         CH.sub.3                                         
                             salt (e)                                     
                                   acetone/ether                          
1T    C.sub.6 H.sub.5 CH.sub.2                                            
                     H   CH.sub.3                                         
                             base  190-193                                
      CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.4 CH.sub.3                       
                         CH.sub.3                                         
                             HCl   acetone/ether                          
1U    C.sub.6 H.sub.5 CH.sub.2                                            
                     CH.sub.3 O                                           
                         CH.sub.3                                         
                             base  226-227                                
      CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.4 CH.sub.3                       
                         CH.sub.3                                         
                             HCl   acetone/ether                          
IV    CH.sub.3       CH.sub.3 O                                           
                         CH.sub.3                                         
                             base  229-231                                
      CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.2 CH(CH.sub.3).sub.2             
                         CH.sub.3                                         
                             HCl   acetone                                
1W    CH.sub.3       CH.sub.3 O                                           
                         CH.sub.3                                         
                             base  178-181 (g)                            
      CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.5 CH.sub.3                       
                         CH.sub.3                                         
                             HCl   acetone/ether                          
1X    CH.sub.3       CH.sub.3 O                                           
                         H   base  oil                                    
      CH.sub.2 CH.sub.2 CO(CH.sub. 2).sub.2 CH(CH.sub.3).sub.2            
                         CH.sub.3                                         
                             base                                         
1Y    CH.sub.3       CH.sub.3 O                                           
                         CH.sub.3                                         
                             base  209-212                                
      CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.3 CH.sub.3                       
                         CH.sub.3                                         
                             HCl   ethanol/ether                          
1Z    CH.sub.3       CH.sub.3 O                                           
                         CH.sub.3                                         
                             base  137-141                                
      CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.2 C.sub.6 H.sub.5                
                         CH.sub.3                                         
                             HBr . H.sub.2 O                              
                                   H.sub.2 O                              
__________________________________________________________________________
 (a) pToluenesulfonate hemihydrate                                        
 (b) Hydrochloride                                                        
 (c) Cyclopropylmethyl?                                                   
 (d) pToluenesulfonate                                                    
 (e) Methanesulfonate                                                     
 (f) Picrate                                                              
 (g) The ptoluenesulfonate has m.p. 188- 190° C. (from acetone)    
 
    
     Following a procedure similar to that described in Example 1A or 1B above, using an appropriate 7-R 2  -1-R 1  -3-lower-alkanoyl-4aα-R 3  -5α-R 4  -1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline of formula II, there are obtained the following 8-R 2  -6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11-(ax)-R 3  -11(eq)-(CH 2  CH 2  COR 5 )-2,6-methano-3-benzazocines of formula I in Table 1b, where in each case R 2  &#39;, R 2  &#34;, R 2  &#39;&#34; and R 8  are each hydrogen. 
     
                       TABLE 1b                                                    
______________________________________                                    
Example                                                                   
       R.sub.1 /CH.sub.2 Z R.sub.2  R.sub.3 /R.sub.4                      
______________________________________                                    
1AA    CH.sub.3            CH.sub.3 O                                     
                                    CH.sub.3                              
       CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.4 CH.sub.3                      
                                    C.sub.2 H.sub.5                       
1AB    C.sub.6 H.sub.5 CH.sub.2                                           
                           CH.sub.3 O                                     
                                    CH.sub.3                              
       CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.2 CH(CH.sub.3).sub.2            
                                    CH.sub.3                              
1AC    CH.sub.3            CH.sub.3 O                                     
                                    CH.sub.3                              
       CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.2 CH(CH.sub.3).sub.2            
                                    C.sub.2 H.sub.5                       
1AD    CH.sub.3            CH.sub.3 O                                     
                                    CH.sub.3                              
       CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.3 CH(CH.sub.3).sub.2            
                                    CH.sub.3                              
______________________________________                                    
 
    
     Following a procedure similar to that described above in Example 1A or 1B, using an appropriate 7-R 2  -8-R 2  &#39;-1-R 1  -3-lower-alkanoyl-4aα-R 3  -5α-R 4  -1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline of formula II, it is contemplated that the following 8-R 2  -9-R 2  &#39;-6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(ax)-R 3  -11(eq)-(CH 2  CH 2  COR 5 )-2,6-methano-3-benzazocines of formula I in Table 1c can be prepared, where in each case R 2  &#34;, R 2  &#34;&#39; and R 8  are hydrogen. 
     
                                           TABLE 1c                                
__________________________________________________________________________
Example                                                                   
     R.sub.1 /CH.sub.2 Z                                                  
                   R.sub.2 /R.sub.2 &#39;                                     
                            R.sub.3 /R.sub.4                              
__________________________________________________________________________
1AE  C.sub.6 H.sub.5 CH.sub.2                                             
                   H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        C.sub.2 H.sub.5                               
1AF  CH.sub.3      H        CH.sub.3                                      
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.3                                      
1AG  C.sub.6 H.sub.5 CH.sub.2                                             
                   H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.3                                      
1AH  C.sub.6 H.sub.5 CH.sub.2                                             
                   HO       H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.3                                      
1AJ  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COC.sub.3 H.sub.7                                  
                   H        C.sub.2 H.sub.5                               
1AK  cyclohexyl    CH.sub.3 S                                             
                            H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.3                                      
1AL  4-BrC.sub.6 H.sub.4 CH.sub.2 CH.sub.2                                
                   CH.sub.3 O                                             
                            H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.3                                      
1AM  4-ClC.sub.6 H.sub.4 CH.sub.2 CH.sub.2                                
                   CH.sub.3 CONH                                          
                            H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.3                                      
1AN  4-FC.sub.6 H.sub.4 CH.sub.2 CH.sub.2                                 
                   C.sub.2 HOCONH                                         
                            H                                             
     CH.sub. 2 CH.sub.2 CONH.sub.3                                        
                   H        CH.sub.3                                      
1AP  4-Cl-3-CH.sub.3 C.sub.6 H.sub.3 CH.sub.2 CH.sub.2                    
                   H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.3                                      
1AQ  3-CH.sub.3 COOC.sub.6 H.sub.4 CH.sub.2 CH.sub.2                      
                   H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.3                                      
1AR  3,4-(CH.sub.3 O).sub.2 C.sub.6 H.sub.3 CH.sub.2 CH.sub.2             
                   H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.3                                      
1AS  4-CH.sub.3 SC.sub.6 H.sub.4 CH.sub.2 CH.sub.2                        
                   H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.3                                      
1AT  3-CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2                         
                   H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.3                                      
1AU  3-CH.sub.3 CONHC.sub.6 H.sub.4 CH.sub.2 CH.sub.2                     
                   H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.3                                      
1AV                                                                       
      ##STR41##    H        H                                             
     CH.sub. 2 CH.sub.2 COCH.sub.3                                        
                   H        CH.sub.3                                      
1AW  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   Cl       CH.sub.3                                      
1AX  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   Br       CH.sub.3                                      
1AY  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   F        CH.sub.3                                      
1AZ  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   CF.sub.3 CH.sub.3                                      
1BA  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   CH.sub.3 CH.sub.3                                      
1BB  CH.sub.3      C.sub.6 H.sub.5                                        
                            H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.3                                      
1BC  CH.sub.3                                                             
                    ##STR42##                                             
                            H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                            CH.sub.3                                      
1BD  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        H                                             
1BE  CH.sub.3      H        H                                             
     Ch.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.2 CH.sub.2 Cl                          
1BF  CH.sub.3      H                                                      
                             ##STR43##                                    
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H                                                      
1BG  CH.sub.3      H                                                      
                             ##STR44##                                    
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H                                                      
1BH  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.2 CH.sub.2 OCH.sub.3                   
1BJ  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COC.sub.6 H.sub.5                                  
                   H        C.sub.2 H.sub.5                               
1BK  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.2 CH.sub.2 SC.sub.6 H.sub.5            
1BL  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.2 CH.sub.2 SOC.sub.6 H.sub.5           
1BM  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CHCH.sub.2                                    
1BN  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.2 CH.sub.2 SCH.sub.3                   
1BP  CH.sub.3      H        H                                             
     CH.sub.2 CH.sub.2 COCH.sub.3                                         
                   H        CH.sub.2 CH.sub.2 OH                          
1BQ  CH.sub.3      CH.sub.3 O                                             
                            CH.sub.3                                      
     COCH.sub.2 -cyclopropyl                                              
                   H        CH.sub.3                                      
1BR  CH.sub.3      CH.sub.3 O                                             
                            CH.sub.3                                      
     COCH.sub.2 - cyclopentyl                                             
                   H        CH.sub.3                                      
1BS  CH.sub.3      CH.sub.3 O                                             
                            CH.sub.3                                      
     COCH.sub.2 -cyclohexyl                                               
                   H        CH.sub.3                                      
1BT  CH.sub.3      CH.sub.3 O                                             
                            CH.sub.3                                      
     CO(CH.sub.2).sub.2 -cyclohexyl                                       
                   H        CH.sub.3                                      
__________________________________________________________________________
 
    
     EXAMPLE 1BU 
     Heating 1,5α,8-trimethyl-3-acetyl-1,2,3,4,4a,5,10,10a-octahydro-2,5methanobenzo[g]quinoline with formic acid in mesitylene using the procedure described above in Example 1 B affords 3,6(eq),9-trimethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine. 
     EXAMPLE 1BV 
     Heating 1-benzyl-3-acetyl-3,4aα,5α-trimethyl-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline with formic acid in mesitylene using the procedure described above in Example 1B affords 3-benzyl-11(ax),6(eq)-dimethyl-1,2,3,4,5,6-hexahydro-11(eq)-(2-methyl-3-oxobutyl)-2,6-methano-3-benzazocine. 
     EXAMPLE 1BW 
     Heating 1-acetyl-3-pentanoyl-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline with formic acid in mesitylene using the procedure described above in Example 1B affords 3-acetyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxoheptyl)-2,6-methano-3-benzazocine. 
     EXAMPLE 2. 
     A. A solution of 27.0 g. (0.072 mole) of 3-benzyl-8-methoxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine (described in Example 1E) was dissolved in 250 ml. of 48% hydrobromic acid and the mixture heated under reflux for about eleven hours. The mixture was concentrated to a small volume in vacuo, diluted with 100 ml.of water, concentrated again, and finally boiled with about 50 ml. of isopropanol. The solid which separated was collected and dried to give 23 g. of 3-benzyl-8-hydroxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine hydrobromide, m.p. 156°-165° C. 
     Following a procedure similar to that described in Example 2A above using an appropriate 8-methoxy-3-methyl-11(ax)-R 3  -6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-CH 2  CH 2  COR 5  -2,6-methano-3-benzazocine of formula I, the following 8-hydroxy-3-R 1  -11(ax)-R 3  -6(eq)-R 4  -1,2,3,4,5,6-hexahydro-11(eq)-CH 2  CH 2  COR 5  -2,6-methano-3-benzazocines of formula I in Table 2a were prepared where, unless noted otherwise, in each case R 2  is hydroxy, R 2  &#39;, R 2  &#34;, R 2  &#39;&#34; and R 8  are each hydrogen, and R 1 , R 3  and R 4  are each methyl. The form (base or salt) of the starting material and product is given in parentheses along with the respective weights. 
     
                                           TABLE 2a                                
__________________________________________________________________________
Example                                                                   
     R.sub.5     Wt.S.M./Wt.Prod.                                         
                          m.p. (° C.)/Solv.                        
__________________________________________________________________________
 2B  C.sub.5 H.sub.11 (b)                                                 
                4.0 (salt) (a)                                            
                          107-109                                         
                1.8 (base)                                                
                          ethanol                                         
2C   C.sub.2 H.sub.5                                                      
                3.5 (base)                                                
                          265-268                                         
                2.5 (HCl) ethanol/ether                                   
2D   C.sub.3 H.sub.7                                                      
                5.0 (base)                                                
                          264-266                                         
                3.7 (HCl) ethanol                                         
2E   C.sub.4 H.sub.9 (b)                                                  
                5.1 (base)                                                
                          120-122                                         
                1.9 (base)                                                
                          ethyl acetate                                   
2F   (CH.sub.2).sub.2 CH(CH.sub.3).sub.2                                  
                4.0 (HCl) 260-263 (c) (d)                                 
                3.3 (HCl) isopropanol                                     
2G   C.sub.6 H.sub.13                                                     
                4.5 (HCl) 206-209                                         
                2.8 (HCl) isopropanol                                     
2H   C.sub.5 H.sub.11                                                     
                4.5 (HCl) 252-255 (e)                                     
                1.7 (HCl) isopropanol                                     
2J   CH.sub.2 CH(CH.sub.3).sub.2                                          
                5.5 (base)                                                
                          251-254                                         
                2.6 (HCl) ethanol                                         
2K   (CH.sub.2).sub.2 CH(CH.sub.3).sub.2 (b)                              
                7.0 (base)                                                
                          101-103.5                                       
                1.6 (base)                                                
                          ethyl acetate/                                  
                          hexane                                          
2L   (CH.sub.2).sub.2 C.sub.6 H.sub.5                                     
                8.1 (salt) (a)                                            
                          233-235 (s)                                     
                1.6 (CH.sub.3 SO.sub.3 H)                                 
                          ethanol                                         
2M   CH.sub.3   5.8 (base)                                                
                          170-173 (f)                                     
                1.3 (base)                                                
                          ethanol                                         
2N   (CH.sub.2).sub.4 CH.sub.3 (g)                                        
                3.3 (base)                                                
                          140-143                                         
                1.4 (base)                                                
                          ethanol                                         
2P   (CH.sub.2).sub.4 CH.sub.3 (h)                                        
                9.7 (base)                                                
                          138.5-141.5                                     
                4.4 (base)                                                
                          ethanol                                         
2Q   (CH.sub.2).sub.4 CH.sub.3 (i)                                        
                9.2 (base)                                                
                          253-257                                         
                8.6 (HCl) acetone/ether                                   
2R   (CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                  
                6.5 (base)                                                
                          116.5-118.5                                     
                4.2 (base)                                                
                          ethyl acetate/                                  
                          hexane                                          
2S   (CH.sub.2).sub.2 CH(CH.sub.3).sub.2 (g)                              
                5.4 (base)                                                
                          264.5-267                                       
                2.2 (HCl) ethanol                                         
2T   (CH.sub.2).sub.2 CH(CH.sub.3).sub.2 (i)                              
                21.7 (base)                                               
                          160.5-163.5                                     
                24.0 (HCl)                                                
                          ethanol/ether                                   
2U   (CH.sub.2).sub.2 CH(CH.sub.3).sub.2 (j)                              
                4.0 (HCl) 270-273                                         
                3.0 (HCl) ethanol/ether                                   
2V   (CH.sub.2).sub.2 cyclopentyl                                         
                12.7 (base)                                               
                          230-235 (k)                                     
                4.8(H.sub.2 SO.sub.4)                                     
                          ethanol/ether                                   
2W   C.sub.6 H.sub.5                                                      
                5.8 (base)                                                
                          182-184.5                                       
                1.9 (base)                                                
                          ethyl acetate/                                  
                          hexane                                          
2X   3-CH.sub.3 C.sub.6 H.sub.4                                           
                6.5 (base)                                                
                          203-206                                         
                1.9 (base)                                                
                          methanol                                        
2Y   4-CH.sub.3 C.sub.6 H.sub.4                                           
                3.0 (base)                                                
                          273-276                                         
                1.8 (CH.sub.3 SO.sub.3 H)                                 
                          methanol                                        
2Z   CH.sub.2 C.sub.6 CH.sub.5                                            
                4.2 (base)                                                
                          228-231                                         
                3.1 (CH.sub.3 SO.sub.3 HO)                                
                          methanol                                        
2AA  CH.sub.2 C.sub.6 H.sub.4 CH.sub.3 (3)                                
                5 (base)  232-234                                         
                3.0 (CH.sub.3 SO.sub.3 H)                                 
                          methanol                                        
2AB  CH(CH.sub.3).sub.2                                                   
                5.3 (base)                                                
                          263-266                                         
                1.9 (HCl) isopropanol/ether                               
2AC  cyclopentyl                                                          
                6.8 (base)                                                
                          142-148                                         
                1.8 (base)                                                
                          ethyl acetate/hexane                            
2AD  (CH.sub.2).sub.2 cyclobutyl                                          
                5.5 (CH.sub.3 SO.sub.3 H)                                 
                          271-275                                         
                3.9 (HCl) methanol/ether                                  
2AE  CH.sub.2 cyclobutyl                                                  
                2.4 (base)                                                
                          278-281                                         
                1.6 (HCl) isopropanol/methanol                            
2AF  (CH.sub.2).sub.2 CH(CH.sub.3).sub.2 (1)                              
                5.0 (base)                                                
                          218-223                                         
                2.6 (CH.sub.3 SO.sub.3 H)                                 
                          ethanol/ether                                   
2AG  (CH.sub.2).sub.4 CH.sub.3 (1)                                        
                3.9 (base)                                                
                          192-195                                         
                2.4 (CH.sub.2 SO.sub.3 H)                                 
                          ethanol/ether                                   
2AH  (CH.sub.2).sub.4 CH.sub. 3 (m)                                       
                6.5 (base)                                                
                          213-217                                         
                5.7 (H.sub.2 SO.sub.4)                                    
                          ethanol                                         
2AJ  (CH.sub.2).sub.4 CH.sub.3 (n)                                        
                5.0 (base)                                                
                          207-211                                         
                2.7 (H.sub.2 SO.sub.4)                                    
                          ethanol/ether                                   
2AK  C(CH.sub.3).sub.2 (CH.sub.2).sub.3 CH.sub.3                          
                3.1 (base)                                                
                          178-181                                         
                1.4 (CH.sub.3 SO.sub.3 H)                                 
                          methanol/acetone                                
2AL  C(CH.sub.3).sub.2 C.sub.2 H.sub.5                                    
                6.7 (base)                                                
                          253-255                                         
                4.1 (CH.sub.3 SO.sub.3 H)                                 
                          methanol/ether                                  
2AM  C(CH.sub.3).sub.3 (CH.sub.2).sub.2 CH.sub.3                          
                ca. 7.6 (CH.sub.3 SO.sub.3 H)                             
                          217-220                                         
                1.3 (CH.sub.3 SO.sub.3 H)                                 
                          methanol                                        
2AN  (CH.sub.2).sub.4 CH.sub.3 (p)                                        
                21.4 (base)                                               
                          196-199                                         
                20.0 (HBr)                                                
                          (q)                                             
2AP  CH.sub.2 cyclopentyl                                                 
                8.9 (base)                                                
                          192-196                                         
                6.4 (H.sub.2 SO.sub.4)                                    
                          ethanol/ether                                   
2AQ  (CH.sub.2).sub.2 CH(CH.sub.3).sub.3                                  
                12.7(base)                                                
                          185-190                                         
                10.4 (HBr)                                                
                          (r)                                             
__________________________________________________________________________
 (a) pToluenesulfonate-                                                   
 (b) R.sub.3 is hydrogen                                                  
 (c) A sample of the racemic base was resolved with 1 and dmandelic acid t
 give, respectively, the 1mandelate, m.p. 190-193° C. (from        
 acetone),[α].sub.D.sup.25 = -6.9°, and the dmandelate, m.p. 
 191-193° C. (from acetone), [α].sub.D.sup.25 = +5.5°.
 Cleavage of the two mandelate salts to the respective free bases and     
 conversion of the latter to the hydrochlorides gave, respectively, the 1 
 and dhydrochlorides, m.p. 240-242° C. (from ethanol/ether),       
 [α].sub.D.sup.25 = -32.2° and m.p. 240-242° C. (from 
 ethanol/ether), [α].sub.D.sup.25 = +32.1°. The l and d      
 methanesulfonates showed, respectively, m.p. 215-218° C.,         
 [α].sub.D.sup.25 = -26.3° and m.p. 214-216° C.,      
 [α].sub.D.sup.25 = +27.3°. The dhydrobromide showed m.p.    
 237-239° C., [α].sub.D.sup.22 = +28.9°.              
 (d) The methanesulfonate has m.p. 189-191° C. (from acetone/diethy
 ether).                                                                  
 (e) The methanesulfonate has m.p. 178-179° C. (from acetone); the 
 free base has m.p. 131-133° C. (from methanol); and the           
 2naphthalenesulfonate has m.p. 195-198° C. (from methanol/diethyl 
 ether). A sample of the racemic base was resolved with 1 and d mandelic  
 acid to give, respectively, the 1 mandelate, m.p. 196-198° C. (fro
 acetone), [α].sub.D.sup.25 = -5.2°, and the d mandelate, m.p
 195-197° C. (from acetone), [α].sub.D.sup.25 = +5.3°.
 Cleavage of the two mandelate salts to the respective free bases and     
 converison of the latter to the methanesulfonates gave, respectively, the
 l and d methanesulfonates, m.p. 212-214° C. (from methanol/diethyl
 ether), [α].sub.D.sup.25 = -25.7° and m.p. 212-214° C
 (from methanol/diethyl ether), [α].sub.D.sup.25 = +26.7°.   
 (f) The methanesulfonate has m.p. 265-268° C. (from ethanol/ether)
 (g) R.sub.4 is C.sub.2 H.sub.5                                           
 (h) R.sub.1 is hydrogen                                                  
 (i) R.sub.1 is benzyl                                                    
 (j) R.sub.3 /R.sub.4 are --(CH.sub.2).sub.4                              
 (k) A sample of the racemic base was resolved with d and lmandelic acid t
 give, respectively, the dmandelate, m.p. 200-202° C. (from acetone
 and the 1mandelate, m.p. 198-201° C. (from acetone). Cleavage of  
 the mandelate salts to the respective free bases and conversion of the   
 latter to the methanesulfonates gave, respectively, the 1 and            
 dmethanesulfonates, m.p. 246-249° C. (from methanol/ether),       
 [α].sub.D.sup.25 = -24.4° and m.p. 246-248° C. (from 
 methanol/ether), [α].sub.D.sup.25 = +25.8°.                 
 (l) R.sub.3 and R.sub.4 are both C.sub.2 H.sub.5.                        
 (m) R.sub.3 and R.sub.4 together are --(CH.sub.2).sub.4                  
 (n) R.sub.3 is C.sub.2 H.sub.5 ; R.sub.4 is                              
 (p) R.sub.1 is benzyl.                                                   
 (q) The crude hydrobromide salt as isolated directly from the reaction   
 mixture showed m.p. 196-199° C. A small sample recrystallized from
 ethanol/ether gave m.p. 201-205° C.                               
 (r) The crude hydrobromide salt as isolated directly from the reaction   
 mixture showed m.p. 185-190° C. A small sample recrystallized from
 ethanol/ether gave m.p. 199-202° C.                               
 (s) The ethanesulfonate shows m.p. 226-228° C. (from acetone).    
 
    
     Following a procedure similar to that described in Example 2 above, using an appropriate 8-methoxy-3,6(eq),11(ax)-trimethyl-1,2,3,4,5,6-hexahydro-11(eq)-CH 2  CH 2  COR 5  -2,6-methano-3-benzazocine of formula I, the following 8-hydroxy-3,6(eq), 11(ax)-trimethyl-1,2,3,4,5,6-hexahydro-11(eq)-CH 2  CH 2  COR 5  -2,6-methano-3-benzazocines are prepared where, in each case, R 2  is hydroxy; R 2  &#39;, R 2  &#34;, R 2  &#39;&#34; and R 8  are each hydrogen; and R 1 , R 3  and R 4  are each methyl. 
     
                       TABLE 2b                                                    
______________________________________                                    
Example           R.sub.5                                                 
______________________________________                                    
2AR               CH.sub.2 -cyclopropyl                                   
2AS               CH.sub.2 -cyclopentyl                                   
2AT               CH.sub.2 -cyclohexyl                                    
2AU               CH.sub.2 CH.sub.2 -cyclohexyl                           
______________________________________                                    
 
    
     EXAMPLE 3 
     A. A solution of 23.1 g. (0.05 mole) of 3-benzyl-8-hydroxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine hydrobromide (described in Example 2A) in 150 ml. of DMF was reduced with hydrogen over 10 g. of 10% palladium-on-charcoal using the procedure described in Example 9A below. The product obtained was recrystallized from ethanol to give 16.1 g. of 8-hydroxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine hydrobromide, m.p. 235°-237° C. (from ethanol). 
     Following a procedure similar to that described in Example 3A above using an appropriate 8-R 2  -3-benzyl-11(ax)-R 3  -6(eq)-R 4  -1,2,3,4,5,6-hexahydro-11(eq)-CH 2  Z-2,6-methano-3-benzazocine of formula I, the following 8-R 2  -11(ax)-R 3  -6(eq)-R 4  -1,2,3,4,5,6-hexahydro-11(eq)-CH 2  Z-2,6-methano-3-benzazocines of formula I in Table 3 were prepared where in each case R 1 , R 2  &#39;, R 2  &#34;, R 2  &#34;&#39; and R 8  are hydrogen. Compounds for which no value for R 6  is given are the ketones (Z is CH 2  COR 5 ). Otherwise the compounds are the carbinols [Z is CH 2  C(R 5 )(R 6 )OH]. The form (base or salt) of the starting material and product is given in parentheses along with the respective weights. 
     
                                           TABLE 3                                 
__________________________________________________________________________
Example                                                                   
     R.sub.2                                                              
         R.sub.5 /R.sub.6                                                 
                  R.sub.3 /R.sub.4                                        
                      Wt.S.M./Wt.Prod.                                    
                                m.p.(°C.)/Solv.                    
__________________________________________________________________________
3B   CH.sub.3 O                                                           
         CH.sub.3 H   21.2 (base)                                         
                                189-193                                   
         --       CH.sub.3                                                
                      11.4 (HCl)                                          
                                ethanol                                   
3C   CH.sub.3 0                                                           
         C.sub.5 H.sub.11                                                 
                  CH.sub.3                                                
                      13.8 (HCl)                                          
                                179-182                                   
         --       CH.sub.3                                                
                      5.8 (HCl) methanol/ether                            
3D   H   C.sub.5 H.sub.11                                                 
                  CH.sub.3                                                
                      4.2 (HCl) 155-157                                   
         --       CH.sub.3                                                
                      2.2 (HCl) acetone/ether                             
3E   CH.sub.3 O                                                           
         CH.sub.3 CH.sub.3                                                
                      11.8 (HCl)                                          
                                130.0-132.5                               
         CH.sub.3 CH.sub.3                                                
                      6.5 (base)                                          
                                --                                        
3F   CH.sub.3 O                                                           
         C.sub.4 H.sub.9                                                  
                  CH.sub.3                                                
                      9.0 (HCl) 170-172                                   
         --       CH.sub.3                                                
                      6.3 (HCl) acetone                                   
3G   HO  (CH.sub.2).sub.4 CH.sub.3                                        
                  CH.sub.3                                                
                      4.7 (HCl) 209-211                                   
         --       CH.sub.3                                                
                      2.6 (HCl) (a)                                       
                                ethanol                                   
3H   HO  (CH.sub.2).sub.2 CH(CH.sub.3).sub.2                              
                  CH.sub.3                                                
                      24.0(HCl) 160.5-163.5                               
         --       CH.sub.3                                                
                      4.6 (base)                                          
                                ethyl acetate                             
3J   CH.sub.3 O                                                           
         (CH.sub.2).sub.2 CH(CH.sub.3 ).sub.2                             
                  CH.sub.3                                                
                      17.5(HCl) 158-167                                   
                  CH.sub.3                                                
                      2.8 (H.sub.3 PO.sub.4 )                             
                                water                                     
__________________________________________________________________________
 (a) The free base has m.p. 137-141° C. (from ethyl acetate)       
 
    
     EXAMPLE 4 
     A. A mixture of 11.4 g. (0.03 mole) of 8-hydroxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine hydrobromide (described in Example 3A), 5.4 g. of sodium bicarbonate and 5.2 g. (0.04 mole) of cyclopropylmethyl bromide in 150 ml. of DMF was heated under reflux for about nine hours and then concentrated to a small volume in vacuo. The residue was partitioned between ammonium hydroxide and ethyl acetate, the organic layer separated, and the aqueous layer extracted with additional portions of ethyl acetate. The combined extracts were washed once with water, then with brine, dried, filtered and taken to dryness to give 12.1 g. of crude product which was converted to the hydrochloride salt. The latter was recrystallized once from acetonitrile and once from ethanol/ether to give 5.2 g. of 3-cyclopropylmethyl-8-hydroxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine hydrochloride, m.p. 147°-154° C. 
     B. Following a procedure similar to that described in Example 4A, 3-cyclopropylmethyl-8-methoxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine (12.9 g.) was prepared by reaction of 15.0 g. (0.04 mole) of 8-methoxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)2,6-methano-3-benzazocine (described in Example 3B) with cyclopropylmethyl bromide in the presence of sodium bicarbonate in DMF. 
     C. 3,6(eq)-Dimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine p-toluenesulfonate (9.9 g.) m.p. 199°-201° C. (from ethanol), was prepared by reductive alkylation of 11.4 g. of 8-hydroxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine hydrobromide (described in Example 3A) with formaldehyde and triethylamine over palladium-on-charcoal in ethanol under about 50 p.s.i. of hydrogen, the product being isolated in the manner described above in Example 4A. 
     D. 3,6-(eq)-Dimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine (7.5 g.) was prepared by reductive alkylation of 8.2 g. of 8-methoxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine hydrochloride (described in Example 3B) with formaldehyde and triethylamine over palladium-on-charcoal in ethanol under about 50 p.s.i. of hydrogen using the procedure described in Example 4C. The hydrochloride salt gives m.p. 181°-183° C. (from ethanol). 
     E. 3,6(eq),11(ax)-Trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine hydrochloride (5.5 g.), m.p. 212°-214° C. (from acetone) was prepared by reductive alkylation of 7.2 g. of 6(eq),11(ax)-dimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine with 2.0 cc. of 37% aqueous formaldehyde and 3.8 cc. of 97% formic acid. The p- toluenesulfonate gives m.p. 200°-201° C. (from ethanol/diethyl ether). 
     F. 3-Cyclobutylmethyl-6(eq),11(ax)-dimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine hydrochloride (2.1 g.), m.p. 207°-209° C. (from acetone) was prepared by reaction of 0.15 mole (from 5.9 g. of the hydrochloride) of 6(eq),11(ax)-dimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine with 2.5 g. of cyclobutylmethyl bromide in 60 ml. of DMF in the presence of 1.5 g. of sodium bicarbonate. 
     G. 3,6(eq),11(ax)-Trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxoheptyl)-2,6-methano-3-benzazocine hydrochloride (3.2 g.), m.p. 209°-211° C. (from acetone/ether) was prepared by the reductive alkylation of 5.3 g. of 6(eq), 11(ax)-dimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxoheptyl)-2,6-methano-3-benzazocine with 1.5 ml. of 37% aqueous formaldehyde in 100 ml. of ethanol over 1.0 g. of palladium-on charcoal under a hydrogen pressure of about 45 p.s.i. 
     H. 3-Ethyl-6(eq),11(ax)-dimethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine was prepared by reaction of 0.02 mole of 6(eq),11(ax)-dimethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methane-3-benzazocine with 5 ml. of acetic anhydride in 50 ml. of dry pyridine. The resulting 3-acetyl-6(eq),11(ax)-dimethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine (3.4 g., m.p. 56°-59° C.) was dissolved in 100 ml. of toluene with 11 ml. of ethylene glycol and 0.5 g. of p-toluenesulfonic acid and the mixture distilled until no further water was produced. The corresponding ethylene glycol ketal (4.0 g.) was isolated as an oil from the toluene solution after washing the latter with aqueous bicarbonate. Reduction of the ketal with 1.2 g. of lithium aluminum hydride in 150 ml. of tetrahydrofuran using the procedure described above in Example 8A afforded 1.7 g. of the final product in the form of the ethylene glycol ketal hydrochloride, m.p. 198°-201° C. (from ethyl acetate). Hydrolysis of the latter in dilute hydrochloric acid gives the free ketone. 
     J. 3-Cyclopropylmethyl-6(eq),11(ax)-dimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine methanesulfonate (2.4 g.), m.p. 211°-213° C. (from methanol) was prepared by reaction of 3.8 g. (0.01 mole) of 6(eq),11(ax)-dimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine with 1.7 g. (0.013 mole) of cyclopropylmethyl bromide in 25 ml. of DMF in the presence of 2.1 g. of sodium bicarbonate. 
     K. 3-Ethyl-6(eq),11(ax)-dimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxo-6-methylheptyl)-2,6-methano-3-benzazocine (1.6 g.) m.p. 116°-118.5° C. (from ethyl acetate/hexane) was prepared by reaction of 6.0 g. (0.018 mole) of 6(eq),11(ax)-dimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxo-6-methyl-heptyl)-2,6-methano-3-benzazocine with 2.11 ml. (0.026 mole) of ethyl iodide in 45 ml. of DMF in the presence of 2.2 g. of sodium bicarbonate. 
     L. 3-Cyclopropylmethyl-6(eq),11(ax)-dimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxo-6-methylheptyl)-2,6-methano-3-benzazocine methanesulfonate (2.2 g.), m.p. 190.5-193.0 (from ethanol/ether) was prepared by reaction of 4.2 g. (0.012 mole) of 6(eq),11(ax)-dimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxo-6-methylheptyl)-2,6-methano-3-benzazocine with 1.8 g. (0.013 mole) of cyclopropylmethyl bromide in 30 ml. of DMF in the presence of 1.1 g. of sodium bicarbonate. 
     M. 3-Ethyl-6(eq),11(ax)-dimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine (3.8 g.), m.p. 140.5°-144° C. (from ethanol) was prepared by reaction of 6.2 g. (0.018 mole) of 6(eq),11(ax)-dimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine with 2.2 ml. (0.027 mole) of ethyl iodide in 45 ml. of DMF in the presence of 2.3 g. of sodium bicarbonate. 
     N. 3-Propyl-6(eq),11(ax)-dimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine methanesulfonate (2.1 g.), m.p. 154°-157° C. (from ethanol) was prepared by reaction of 3.6 g. (0.011 mole) of 6(eq),11(ax)dimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine with 1.53 ml. (0.016 mole) of propyl iodide in 30 ml. of DMF in the presence of 1.32 g. of sodium bicarbonate. 
     P. 3-(2-Phenylethyl)-6(eq),11(ax)-dimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxo-6-methylheptyl)-2,6-methano-3-benzazocine hydrosulfate (1.9 g.), m.p. 206°-208° C. (from ethanol/ether) was prepared by reaction of 5.0 g. (0.014 mole) of 6(eq), 11(ax)-dimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxo-6-methylheptyl)-2,6-methano-3-benzazocine with 2.1 ml. (0.015 mole) of 2-phenylethyl bromide in 70 ml. of DMF in the presence of 1.3 g. of sodium bicarbonate. 
     Following a procedure similar to that described in Example 4A, using the 8-hydroxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine described in Example 3A and an appropriate alkylating agent, R 1  Hal, there are prepared the following compounds of formula I in Table 4, where in each instance R 2  is HO; R 2  &#39;, R 2  &#34;, R 2  &#34;&#39; and R 3  are each hydrogen; R 4  is CH 3  ; and CH 2  Z is CH 2  CH 2  COCH 3 . 
     
                       TABLE 4                                                     
______________________________________                                    
Example           R.sub.                                                  
______________________________________                                    
4Q                CH.sub.2 CH═CH.sub.2                                
4R                CH.sub.2 CH═C(CH.sub.3).sub.2                       
4S                CH.sub.2 C.tbd.CH                                       
4T                CH.sub.2 C.tbd.CCH.sub.3                                
4U                CH.sub.2 CH═CCl.sub.2                               
______________________________________                                    
 
    
     EXAMPLE 5 
     A. A solution of 4.7 g. (0.16 mole) of 6(eq)-ethyl-1,2,3,4,5,6-hexahydro-3-methyl-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine (from the hydrochloride described in Example 1 A) in 28 ml. of diethyl ether was added dropwise with stirring to 28 ml. (0.05 mole) of a 1.8 M solution of methyl lithium in diethyl ether. The mixture was stirred under nitrogen for about one hour, poured into an ice/aqueous ammonium chloride solution, and the ether layer separated and washed with water. The organic layer was dried, filtered, and taken to dryness to give 4.9 g. of residue which was converted to the methanesulfonate salt in methanol/diethyl ether. The latter was recrystallized from methanol/diethyl ether to give 2.5 g. of 3-methyl-6(eq)-ethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-3-hydroxy-butyl)-2,6-methano-3-benzazocine methanesulfonate, m.p. 173°-174° C. 
     Following a procedure similar to that described in Example 5A, using an appropriate 8-R 2  -6-(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine described above and an appropriate lower-alkyl lithium (R 6  Li), there were prepared the 8-R 2  -6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(eq)-(3-methyl-3-hydroxy-lower-alkyl)-2,6-methano-3-benzazocines of formula I in Table 5a where, in each instance, R 2  &#39;, R 2  &#34;, R 2  &#34;&#39; and R 7  are hydrogen. Unless noted otherwise, products were isolated as, and melting points recorded for, the free base form. 
     
                                           TABLE 5a                                
__________________________________________________________________________
Example                                                                   
     R.sub.1 /R.sub.2                                                     
             R.sub.3 /R.sub.4                                             
                 R.sub.5 /R.sub.6                                         
                          Wt.S.M./Wt. Prod.                               
                                    m.p.(°C.)/Solv.                
__________________________________________________________________________
 5B  CH.sub.3                                                             
             H   CH.sub.3 3.6 (base)                                      
                                    203-206                               
     HO      C.sub.2 H.sub.5                                              
                 CH.sub.3 1.2 (base)                                      
                                    ethyl acetate                         
5C   C.sub.3 H.sub.5 --CH.sub.2 (a)                                       
             H   CH.sub.3 4.0 (base)                                      
                                    184-186                               
     H       C.sub.2 H.sub.5                                              
                 CH.sub.3 2.2 (HCl) CH.sub.3 CN/ether                     
5D   C.sub.3 H.sub.5 --CH.sub.2 (a)                                       
             H   CH.sub.3 11.4 (base)                                     
                                    138-140                               
     HO      CH.sub.3                                                     
                 CH.sub.3 3.3 (base)                                      
                                    ethyl acetate                         
5E   C.sub.6 H.sub.5 CH.sub.2                                             
             H   CH.sub.3 3.78 (base)                                     
                                    252                                   
     CH.sub.3 O                                                           
             CH.sub.3                                                     
                 t-C.sub.4 H.sub.9                                        
                          1.25 (HCl)                                      
                                    ethanol                               
5F   CH.sub.3                                                             
             H   CH.sub.3 4.2 (base)                                      
                                    182-183                               
     HO      CH.sub.3                                                     
                 CH.sub.3 2.6 (base)                                      
                                    ethyl acetate                         
5G   CH.sub.3                                                             
             H   CH.sub.3 7.5 (base)                                      
                                    oil                                   
     CH.sub.3 O                                                           
             CH.sub.3                                                     
                 C.sub.4 H.sub.9                                          
                          11.3 (base)                                     
5H   C.sub.6 H.sub.5 CH.sub.2                                             
             H   CH.sub.3 3.78 (base)                                     
                                    oil                                   
     CH.sub.3 O                                                           
             CH.sub.3                                                     
                 C.sub.2 H.sub.5                                          
                          4.5 (base)                                      
5J   C.sub.3 H.sub.5 --CH.sub.2 (a)                                       
             H   CH.sub.3 13.4 (base)                                     
                                    184-185 (c)                           
     HO(c)   CH.sub.3                                                     
                 C.sub.4 H.sub.9                                          
                          10.2 (b)  ethanol/ether                         
5K   C.sub.6 H.sub.5 CH.sub.2                                             
             H   CH.sub.3 20.0 (base)                                     
                                    oil                                   
     CH.sub.3 O                                                           
             CH.sub.3                                                     
                 C.sub.3 H.sub.7                                          
                          21.8 (base)                                     
5L   C.sub.6 H.sub.5 CH.sub.2                                             
             CH.sub.3                                                     
                 CH.sub.3 11.5 (base)                                     
                                    223-227                               
     CH.sub.3 O                                                           
             CH.sub.3                                                     
                 t-C.sub.4 H.sub.9                                        
                          2.4 (HCl) ethanol/ether                         
5M   C.sub.3 H.sub.5 CH.sub.2 (a)                                         
             H   CH.sub.3 12.0 (base)                                     
                                    --                                    
     CH.sub.3 O                                                           
             C.sub.2 H.sub.5                                              
                 t-C.sub.4 H.sub.9                                        
                          12.9 (base)                                     
                                    --                                    
5N   C.sub.6 H.sub.5 CH.sub.2                                             
             CH.sub.3                                                     
                 CH.sub.3 18.8 (HCl)                                      
                                    246-248                               
     H       CH.sub.3                                                     
                 t-C.sub.4 H.sub.9                                        
                          3.6 (HCl) ethanol/ether                         
5P   C.sub.6 H.sub.5 CH.sub.2                                             
             CH.sub.3                                                     
                 CH.sub.3 13.7 (base)                                     
                                    233-234                               
     CH.sub.3 O                                                           
             CH.sub.3                                                     
                 CH.sub.3 12.1 (HCl)                                      
                                    ethanol/ether                         
5Q   C.sub.6 H.sub.5 CH.sub.2                                             
             H   t-C.sub.4 H.sub.9                                        
                          37.7 (base)                                     
                                    249                                   
     CH.sub.3 O                                                           
             CH.sub.3                                                     
                 CH.sub.3 8.7 (HCl) ethanol/ether                         
5R   C.sub.6 H.sub.5 CH.sub.2                                             
             CH.sub.3                                                     
                 t-C.sub.4 H.sub.9                                        
                          11.9 (base)                                     
                                    249-252                               
     CH.sub.3 O                                                           
             CH.sub.3                                                     
                 CH.sub.3 4.0 (HCl) ethanol                               
5S   CH.sub.3                                                             
             CH.sub.3                                                     
                 (CH.sub.2).sub.2 CH(CH.sub.3).sub.2                      
                          20.4 (base)                                     
     CH.sub.3 O                                                           
             CH.sub.3                                                     
                 CH.sub.3 (d)                                             
__________________________________________________________________________
 (a) Cyclopropylmethyl                                                    
 (b) Methanesulfonate                                                     
 (c) Starting material was methyl ether described in Example 4B, and the  
 product obtained from reaction with butyl lithium was cleaved, without   
 characterization, to the 8HO compound with sodium propanethiol using the 
 procedure described in Example 9A                                        
 (d) The product was separated into two isomeric pairs of racemates by hig
 pressure liquid chromatography on silica gel in 60% hexane/40% ethyl     
 acetate. There was thus obtained 3.6 g. of one isomer, designated Isomer 
 I, isolated as the hydrochloride, m.p. 195-197° C. (from          
 ethanol/ether) and 3.5 g. of another isomer, designated Isomer II,       
 isolated as the free base, as a syrup.                                   
 
    
     Following a procedure similar to that described in Example 5A, using an appropriate 8-R 2  -6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(ax)-R 3  -11(eq)-CH 2  CH 2  COR 5  -2,6-methano-3-benzazocine described above and an appropriate lower-alkyl, phenyl or phenyllower-alkyl lithium, R 6  Li, there are obtained the respective 8-R 2  -6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(ax)-R 3  -11(eq)-CH 2  CH 2  C(R 5 )(R 6 )OH-2,6-methano-3-benzazocines of formula I listed in Table 5b where, in each instance, R 2  &#39;, R 2  &#34;, R 2  &#34;&#39;, R 7  and R 8  are hydrogen. 
     
                                           TABLE 5b                                
__________________________________________________________________________
Example                                                                   
     R.sub.1      R.sub.2 R.sub.3                                         
                             R.sub.4                                      
                                R.sub.5                                   
                                   R.sub.6                                
__________________________________________________________________________
 5T  cyclohexyl   CH.sub.3 S                                              
                          H  CH.sub.3                                     
                                CH.sub.3                                  
                                   CH.sub.3                               
5U   4-BrC.sub.6 H.sub.4 CH.sub.2 CH.sub.2                                
                  CH.sub.3 O                                              
                          H  CH.sub.3                                     
                                CH.sub.3                                  
                                   CH.sub.3                               
5V   4-ClC.sub.6 H.sub.4 CH.sub.2 CH.sub.2                                
                  CH.sub.3 CONH                                           
                          H  CH.sub.3                                     
                                CH.sub.3                                  
                                   CH.sub.3                               
5W   4-FC.sub.6 H.sub.4 CH.sub.2 CH.sub.2                                 
                  C.sub.2 H.sub.5 OCONH                                   
                          H  CH.sub.3                                     
                                CH.sub.3                                  
                                   CH.sub.3                               
5X   4-Cl-3-CH.sub.3 C.sub. 6 H.sub.3 CH.sub.2 CH.sub.2                   
                  H       H  CH.sub.3                                     
                                CH.sub.3                                  
                                   CH.sub.3                               
5Y   3-CH.sub.3 COOC.sub.6 H.sub.4 CH.sub.2 CH.sub.2                      
                  H       H  CH.sub.3                                     
                                CH.sub.3                                  
                                   CH.sub.3                               
5Z   3,4-(CH.sub.3 O).sub.2 C.sub.6 H.sub.3 CH.sub.2 CH.sub.2             
                  H       H  CH.sub.3                                     
                                CH.sub.3                                  
                                   CH.sub.3                               
5AA  4-CH.sub.3 SC.sub.6 H.sub.4 CH.sub.2 CH.sub.2                        
                  H       H  CH.sub.3                                     
                                CH.sub.3                                  
                                   CH.sub.3                               
5AB  3-CF.sub.3 C.sub.6 H.sub.4 CH.sub.2 CH.sub.2                         
                  H       H  CH.sub.3                                     
                                CH.sub.3                                  
                                   CH.sub.3                               
5AC  3-CH.sub.3 CONHC.sub.6 H.sub.4 CH.sub.2 CH.sub.2                     
                  H       H  CH.sub.3                                     
                                CH.sub.3                                  
                                   CH.sub.3                               
5AD                                                                       
      ##STR45##   H       H  CH.sub.3                                     
                                CH.sub.3                                  
                                   CH.sub.3                               
5AE  CH.sub.3     H       H  C.sub.2 H.sub.5                              
                                C.sub.6 H.sub.5                           
                                   CH.sub.3                               
5AF  CH.sub.3     H       H  C.sub.2 H.sub.5                              
                                CH.sub.3                                  
                                   C.sub.6 H.sub.5                        
5AG  CH.sub.3     H       CH.sub.3                                        
                             C.sub.2 H.sub.5                              
                                CH.sub.3                                  
                                   C.sub.6 H.sub.5 CH.sub.2 CH.sub.2      
__________________________________________________________________________
 
    
     EXAMPLE 5AH 
     Reaction of 3,6(eq),9-trimethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine (described in Example 1BJ) with methyl lithium in diethyl ether using the procedure described in Example 5A affords 3,6(eq),9-trimethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3-methylbutyl)-2,6-methano-3-benzazocine. 
     EXAMPLE 6 
     A. Reaction of the 3-[2-(4-fluorophenyl)ethyl]-8-ethoxycarbonylamino-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-3-hydroxybutyl)-2,6-methano-3-benzazocine (described in Example 5V) with aqueous alkali in ethanol affords 3-[2-(4-fluorophenyl)ethyl]-8-amino-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-3-hydroxybutyl)-2,6-methano-3-benzazocine. 
     Following a procedure similar to that described in Example 6A, the following 8-R 2  -6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(eq)-(3-methyl-3-hydroxy-lower-alkyl)-2,6-methano-3-benzazocines of formula I are also prepared: 
     B. 3-[2-(3-Hydroxyphenyl)ethyl]-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-3-hydroxybutyl)-2,6-methano-3-benzazocine by alkaline hydrolysis of 3-[2-(3-acetoxyphenyl)ethyl]6-(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-3-hydroxybutyl)-2,6-methano-3-benzazocine (described in Example 5X); and 
     C. 3-[2-(3-Aminophenyl)ethyl]-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-3-hydroxybutyl)-2,6-methano-3-benzazocine by alkaline hydrolysis of 3-[2-(3-acetylaminophenyl)ethyl]-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-3-hydroxybutyl)-2,6-methano-3-benzazocine (described in Example 5AB). 
     EXAMPLE 7 
     A. Reaction of 8-hydroxy-3,6(eq)-dimethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-3-hydroxybutyl)-2,6-methano-3-benzazocine (described in Example 5F) with acetic anhydride affords 8-acetoxy-3,6(eq)-dimethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-3-acetoxybutyl)-2,6-methano-3-benzazocine. 
     Following a procedure similar to that described in Example 7A, using the 3-methyl-6(eq)-ethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-3-hydroxybutyl)-2,6-methano-3-benzazocine described in Example 5A and an appropriate acid chloride in the presence of pyridine, there are obtained the following 3-methyl-6(eq)-ethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-3-R 7  O-butyl)-2,6-methano-3-benzazocines of formula I in Table 7 where, in each instance, R 1 , R 5  and R 6  are CH 3  ; R 2 , R 2  &#39;, R 2  &#34;, R 2  &#39;&#34;, R 3  and R 8  are each hydrogen; and R 4  is C 2  H 5 . 
     
                       TABLE 7                                                     
______________________________________                                    
Example           R.sub.7                                                 
______________________________________                                    
7B                C.sub.6 H.sub.5 CO                                      
7C                4-CH.sub.3 C.sub.6 H.sub.4 CO                           
7D                3-CH.sub.3 OC.sub.6 H.sub.4 CO                          
7E                4-ClC.sub.6 H.sub.4 CO                                  
7F                4-BrC.sub.6 H.sub.4 CO                                  
7G                4-FC.sub.6 H.sub.4 CO                                   
7H                3-CF.sub.3 C.sub.6 H.sub.4 CO                           
______________________________________                                    
 
    
     EXAMPLE 8 
     A. The 3,6(eq)-dimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine p-toluenesulfonate (15.9 g., 0.03 mole) described in Example 1H was hydrolyzed to the free base, and the latter (10.5 g.) dissolved in diethyl ether was added to a stirred slurry of 600 mg. (0.005 mole) of lithium aluminum hydride in ether. The mixture was refluxed for one hour, quenched by the careful addition of 1.2 ml. of water in 10 ml. of tetrahydrofuran followed by excess dilute sodium hydroxide, filtered and the filtrate evaporated to dryness. The residue (10 g.) was converted to the p-toluenesulfonate salt which was recrystallized from ethanol/ether to give 6.2 g. of 3,6(eq)-dimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxyoctyl)-2,6-methano-3-benzazocine p-toluenesulfonate, m.p. 135°-137° C. 
     B. Reduction of 26.0 g. (0.075 mole) of ethyl 3-[8-methoxy-3,6(eq),11(ax)-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-11(eq)-yl]propionate (described in Lewis and Michne U.S. Pat. No. 4,148,794) with 3.6 g. (0.094 mole) of lithium aluminum hydride in 130 ml. of diethyl ether and isolation of the product in the form of the free base afforded 19.0 g. of 8-methoxy-3,6(eq),11(ax)-trimethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxypropyl)-2,6-methano-3-benzazocine, which after several recrystallizations of a small sample from ethanol gave material having m.p. 128°-130° C. 
     C. Reduction of 3-cyclopropylmethyl-6(eq)-ethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine (described in Example 1D) with lithium aluminum hydride in diethyl ether using the procedure described in Example 8A affords 3-cyclopropylmethyl-6(eq)-ethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxybutyl)-2,6-methano-3-benzazocine. 
     EXAMPLE 9 
     A. A solution of 4.72 g. (0.01 mole) of 3-benzyl-6(eq)-methyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3,4,4-trimethylpentyl)-2,6-methano-3-benzazocine (described in Example 5E) in 50 ml. of DMF was reduced with hydrogen over 0.5 g. of palladium-on-charcoal under a hydrogen pressure of about 50 p.s.i. When reduction was complete, the catalyst was removed by filtration, and the solution, containing 6(eq)-methyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3,4,4-trimethylpentyl)-2,6-methano-3-benzazocine was treated with 1.68 g. (0.02 mole) of sodium bicarbonate and 2.0 g. (0.015 mole) of cyclopropylmethyl bromide, and the mixture was warmed with stirring on a steam bath for one hour. 
     The reaction mixture containing crude 3-cyclopropylmethyl-6(eq)-methyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3,4,4-trimethylpentyl)-2,6-methano-3-benzazocine, was distilled at atmospheric pressure, collecting 25 ml. of distillate, and then treated with 2.1 g. (0.05 mole) of a 57% dispersion of sodium hydride in mineral oil and 5 ml. of DMF. The mixture was cooled in an ice bath and treated dropwise with stirring under nitrogen with 4.6 ml. of propanethiol. After refluxing and stirring for about four hours, the reaction mixture was poured into a solution of aqueous ammonium chloride and extracted with 50 ml. of diethyl ether. The product was isolated in the usual manner in the form of the free base which was recrystallized from ethanol to give 2.4 g. of 3-cyclopropylmethyl-6(eq)-methyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3,4,4-trimethylpentyl)-2,6-methano-3-benzazocine, m.p. 195°-198° C. The methanesulfonate gave m.p. 232° C. 
     Following a procedure similar to that described in Example 9A, using an appropriate 8-methoxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-3-benzyl-11(ax)-R 3  -11(eq)-CH 2  Z-2,6-methano-3-benzazocine and an appropriate alkylating agent, R 1  -Hal, (or reductive alkylation with formaldehyde and formic acid using the procedure described in Example 4C), there were obtained the 8-hydroxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-3-R 1  -11(ax)-R 3  -11(eq)-CH 2  Z-2,6-methano-3-benzazocines of formula I in Table 9 where, in each instance unless noted otherwise, R 2  is hydroxy; R 2  &#39;, R 2  &#34;, R 2  &#34;&#39;, R 7  and R 8  are each hydrogen; and R 4  is CH 3 . Compounds for which no value for R 6  is given are the ketones (Z is CH 2  COR 5 ). The compounds are otherwise the carbinols [Z is CH 2  C(R 5 )(R 6 )OH]. Melting points of the products are given in each case for the methanesulfonate salt, and yields are also given for the methanesulfonate unless noted otherwise. 
     
                                           TABLE 9                                 
__________________________________________________________________________
Example                                                                   
     R.sub.1 /R.sub.3                                                     
               R.sub.5 /R.sub.6                                           
                   Wt.S.M./Wt. Prod                                       
                             m.p. (°C.)/Solv.                      
__________________________________________________________________________
9B   CH.sub.3  CH.sub.3                                                   
                   4.72 (HCl)                                             
                             206-208                                      
     H         t-C.sub.4 H.sub.9                                          
                   2.7       methanol/ether                               
9C   CH.sub.3  CH.sub.3                                                   
                   10.9 (base)                                            
                             144-146                                      
     H         C.sub.3 H.sub.7                                            
                   7.4 (base)                                             
                             acetone                                      
9D   C.sub.3 H.sub.5 --CH.sub.2 (a)                                       
               CH.sub.3                                                   
                   2.5 (HCl) 249-252                                      
     CH.sub.3  t-C.sub.4 H.sub.9                                          
                   1.4       methanol/ether                               
9E   C.sub.3 H.sub.5 --CH.sub.2 (a)                                       
               CH.sub.3                                                   
                   9.2 (base)                                             
                             182-183                                      
     H         C.sub.3 H.sub.7                                            
                   1.8       ethanol/ether                                
9F   C.sub.3 H.sub.5 --CH.sub.2 (a)                                       
               CH.sub.3                                                   
                   12.9 (base)                                            
                             225-228                                      
     H(b)      t-C.sub.4 H.sub.9                                          
                   0.42      methanol/ether                               
9G   C.sub.3 H.sub.5 --CH.sub.2 (a)                                       
               t-C.sub.4 H.sub.9                                          
                   3.4 (HCl) 266-268 (h)                                  
     CH.sub.3  CH.sub.3 (c)                                               
                   1.4       methanol/ether                               
9H   CH.sub.3  t-C.sub.4 H.sub.9                                          
                   4.9 (HCl) 219-223 (base)                               
     CH.sub.3  CH.sub.3                                                   
                   1.1 (base)                                             
                             ethyl acetate                                
9J   CH.sub.3  CH.sub.3                                                   
                   11.8 (HCl)                                             
                             179-182 (base)                               
     CH.sub. 3 CH.sub.3                                                   
                   1.3 (base)                                             
                             ethyl acetate                                
9K   CH.sub.3  C.sub.4 H.sub.9                                            
                   9.0 (HCl) 283-285 (HCl)                                
     CH.sub.3  --  2.1 (HC1) methanol/ether                               
9L   CH.sub.3  t-C.sub.4 H.sub.9                                          
                   4.7 (HCl) 190-195(d)                                   
     CH.sub.3  --  1.5 (d)   ethanol/ether                                
9M   C.sub.3 H.sub.5 --CH.sub.2 (a)                                       
               t-C.sub.4 H.sub.9                                          
                   12.3 (HCl)                                             
                             248-250(CH.sub.3 SO.sub.3 H)                 
     H         CH.sub.3 (j)                                               
                   1.3 (CH.sub.3 SO.sub.3 H)                              
                             methanol/ether                               
9N   C.sub.3 H.sub.5 --CH.sub.2 (a)                                       
               CH.sub.3                                                   
                   11.8 (HCl)                                             
                             236-238 (HCl)                                
     CH.sub.3  CH.sub.3                                                   
                   1.2 (HCl) ethanol                                      
9P   C.sub.4 H.sub.7 --CH.sub.2 (e) (f)                                   
               C.sub.5 H.sub.11                                           
                   5.9 (HCl) 213-216 (HCl)                                
     CH.sub.3  --  3.2 (HCl) isopropanol                                  
9Q   CH.sub.3  t-C.sub.4 H.sub.9                                          
                   2.4 (HCl) 242-247 (g)                                  
     CH.sub.3  CH.sub.3                                                   
                   2.4 (CH.sub.3 SO.sub.3 H)                              
                             methanol                                     
9R   CH.sub.3  t-C.sub.4 H.sub.9                                          
                   5.2 (HCl) 212-215                                      
     H         CH.sub.3                                                   
                   2.3 (CH.sub.3 SO.sub.3 H)                              
                             methanol                                     
__________________________________________________________________________
  (a)Cyclopropylmethyl                                                    
  (b)R.sub.4 is C.sub.2 H.sub.5                                           
  (c)Isomeric with compound of Example 9D which was prepared via compound 
 of Example 5L. Compound of Example 9G prepared via compound of Example 1L
  (d)Ethanesulfonate.                                                     
  (e)Cyclobutylmethyl                                                     
  (f)Debenzylated product reacted with 0.013 mole of cyclobutane carboxyli
 acid chloride in chloroform in the presence of triethylamine, and the    
 resulting amide, without purification, converted to the ethylene glycol  
 ketal by reaction with ethylene glycol in the presence of ptoluenesulfoni
 acid in toluene. The ketal was then reduced in tetrahydrofuran with      
 lithium aluminum hydride using the procedure of Example 3A and the       
 product, identical with the compund of Example 4F isolated from an acid  
 medium and then cleaved with sodium propylsulfide.                       
  (g)Isomeric with the compound of Example 9H. Isomers both prepared by   
 reaction of methyl lithium with the same tbutyl ketone (R.sub.5 is       
 tC.sub.4 H.sub.9). Isomeric products, i.e. 3benzyl-6(eq),                
 11(ax)dimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3,4,4-tr
methylpentyl)-2,6-methano-3-benzazocine, are readily separated from one   
 another in the crude product by conversion to the hydrochloride salt. One
 isomeric form is insoluble in ethanol and gives rise to the isomer of    
 Example 9H. The other, much more soluble in ethanol, gives rise to the   
 isomer of Example 9Q. The isomer of Example 9Q predominates over that of 
 Example 9H when methyl lithium is reacted with the tbutyl ketone. The    
 opposite is D.sup.when tbutyl lithium is reacted with the methyl ketone  
 (R.sub.5 is CH.sub.3 -                                                   
  (h)Samples of the free base were resolved into the two optical isomers b
 treating the corresponding racemic des Ncyclopropyl methyl ether (R.sub.1
 is hydrogen and R.sub.2 is CH.sub.3 O) with d and 1 mandelic acid. The   
 former afforded the corresponding dbase. dmandelate (m.p. 163-166°
 C., from ethyl acetate) and the latter the corresponding 1base.1 mandelat
 (m.p. 162-165° C., from ethyl acetate). Conversion of each of thes
 to the free bases and conversion of the free bases to the corresponding  
 Ncyclopropylmethyl-8-hydroxycompounds using the procedure described in   
 Example 9A, and isolation of the products in the form of the             
 methanesulfonate salts afforded to the respective dbase. methanesulfonate
 m.p. 279-282° C. (from methanol), [α].sub.D.sup.25 = +61.0  
 and 1base.methanesulfonate, m.p. 281-285° C. (from methanol),     
 [α].sub.D.sup.25 = -61.3°.                                  
  (j)Isomeric with compound of Example 9A which was prepared via compound 
 of Example 1E. Compound of Example 9M was prepared via compound of Exampl
 1K.                                                                      
 
    
     EXAMPLE 10 
     Using a procedure similar to that described above in Example 9A, 3.19 g. (0.007 mole) of 3-benzyl-6(e),11(ax)-dimethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3,4,4-trimethylpentyl)-2,6-methano-3-benzazocine (described in Example 5N) was debenzylated by reduction over 0.35 g. of palladium-on-charcoal and the resulting 6(eq),11(ax)-dimethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3,4,4-trimethylpentyl)-2,6-methano-3-benzazocine reacted with 2.0 g. (0.015 mole) of cyclopropylmethyl bromide and 1.7 g. (0.020 mole) of sodium bicarbonate and the product isolated in the form of the hydrochloride salt to give 1.5 g. of 3-cyclopropylmethyl-6(eq), 11(ax)-dimethyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3,4-4-trimethylpentyl)-2,6-methano-3-benzazocine hydrochloride, m.p. 232°-233° C. (from ethanol/ether). 
     EXAMPLE 11 
     A. A solution of 15 g. (0.04 mole) of 3-benzyl-8-methoxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine (described in Example 1E) was catalytically debenzylated and the resulting nor-base alkylated with cyclopropylmethyl bromide in the presence of sodium bicarbonate using the procedure described in Example 9A. The resulting 3-cyclopropylmethyl-8-methoxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine (12.9 g.) was dissolved in 125 ml. of toluene and added to 45 ml. of a 2.1 M solution of n-butyl lithium in hexane at -65° C. using the procedure described in Example 5A. The resulting 3-cyclopropylmethyl-8-methoxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3-methylheptyl)-2,6-methano-3-benzazocine (13.4 g.) was dissolved in 130 ml. of DMF and the ether group cleaved by treatment with 7.1 g. (0.168 mole) of a 57% mineral oil dispersion of sodium hydride and 12.8 g. (0.168 mole) of propanethiol in the manner described above in Example 9A. The product was converted to the methanesulfonate salt which was crystallized from ethanol/ether to give 10.2 g. of 3-cyclopropylmethyl-8-hydroxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3-methylheptyl)-2,6-methano-3-benzazocine methanesulfonate, m.p. 184°-185° C. 
     Following a procedure similar to that described in Example 11A, using the 3-benzyl-8-methoxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxobutyl)-2,6-methano-3-benzazocine described in Example 1E, ethyl lithium and an appropriate alkylating agent, R 1  -Hal, (or reductive alkylation with formaldehyde and formic acid using the procedure described in Example 4C), there were obtained the 8-hydroxy-3-R 1  -6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3-methylpentyl)-2,6-methano-3-benzazocines of formula I in Table 11 where, in each instance, R 2  is hydroxy; R 2  &#39;, R 2  &#34;, R 2  &#39;&#34;, R 3 , R 7  and R 8  are hydrogen; R 4  and R 5  are CH 3  ; and R 6  is C 2  H 5 . In each instance, the melting points are given for the methanesulfonate salt, and the yield of product is given for the free base. 
     
                       TABLE 11                                                    
______________________________________                                    
Ex-                                                                       
ample R.sub.1      Wt.S.M./Wt. Prod.                                      
                                m.p.(°C.)/Solv.                    
______________________________________                                    
11B   cyclopropyl-CH.sub.2                                                
                   15.0 (base)  195-196                                   
                   8.3 (base)   acetone                                   
11C   CH.sub.3     15.0 (base)  155-157                                   
                   11.0 (base)  ethanol                                   
______________________________________                                    
 
    
     EXAMPLE 12 
     A. A 5.7 g. sample of 3-methyl-8-methoxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3-methylheptyl)-2,6-methano-3-benzazocine described in Example 5G in DMF was cleaved with sodium propylsulfide (0.063 mole) using the procedure described in Example 9A and the product (3.4 g. of crude base) converted to the methanesulfonate salt which was recrystallized from ethanol/ether to give 2.6 g. of 3-methyl-8-hydroxy-6(eq)-methyl-1,2,3,4,5,6-hexahydro-11(eq)-(3-hydroxy-3-methylheptyl)-2,6-methano-3-benzazocine methanesulfonate, m.p. 184°-186° C. 
     Following a procedure similar to that described in Example 12A using an appropriate 8-methoxy-6(eq)-methyl-11(ax)-R 3  -1,2,3,4,5,6-hexahydro-3-R 1  -11(eq)-CH 2  Z-2,6-methano-3-benzazocine, the following 8-hydroxy-6(eq)-methyl-11(ax)-R 3  -1,2,3,4,5,6-hexahydro-3-R 1  -11(eq)-CH 2  Z-2,6-methano-3-benzazocines of formula I were prepared where, in each case, R 2  &#39;, R 2  &#34;, R 2  &#39;&#34;, R 7  and R 8  are hydrogen; R 4  is CH 3  ; and R 2  is hydroxy. Where no value for R 6  is given, the compound has the ketone structure (Z is CH 2  COR 5 ) but otherwise has the carbinol structure [Z is CH 2  C(R 5 )(R 6 )OH]. 
     
                                           TABLE 12                                
__________________________________________________________________________
Example                                                                   
     R.sub.1 R.sub.3                                                      
           R.sub.5 /R.sub.6                                               
                      Wt.S.M./Wt. Prod.                                   
                                m.p.(°C.)/Solv.                    
__________________________________________________________________________
12B  CH.sub.3                                                             
           C.sub. 5 H.sub.11                                              
                      6.4 (base)                                          
                                176-177 (a)                               
     H     H          1.8 (a)   acetone                                   
12C  C.sub.3 H.sub.5 --CH.sub.2                                           
           C.sub.4 H.sub.9                                                
                      5.0 (base)                                          
                                235-237 (HCl)                             
     CH.sub.3                                                             
           --         2.5 (HCl) isopropanol                               
12D  CH.sub.3                                                             
           CH.sub.2 CH.sub.2 --C.sub.3 H.sub.5                            
                      6.2 (base)                                          
                                128-130 (b)                               
     CH.sub.3                                                             
           --         0.9 (base)                                          
                                ethyl acetate/hexane                      
12E  CH.sub.3                                                             
           (CH.sub.2).sub.2 CH(CH.sub.3).sub.2 (c)                        
                      2.9 (HCl) 204-206                                   
     CH.sub.3                                                             
           CH.sub.3   2.13 (CH.sub.3 SO.sub.3 H)                          
                                methanol/ether                            
12F  CH.sub.3                                                             
           (CH.sub.2).sub.2 CH(CH.sub.2).sub.2 (d)                        
                      3.15 (base)                                         
                                238-241                                   
     CH.sub.3                                                             
           CH.sub.3   1.48 (HCl)                                          
                                ethanol/ether                             
__________________________________________________________________________
 (a) pToluenesulfonate                                                    
 (b) The hydrochloride has m.p. 271-237° C. (from methanol/ether)  
 (c) Isomer I, prepared from Isomer I of Example 5S, and isomeric with    
 compound of Example 12F.                                                 
 (d) Isomer II, prepared from Isomer II of Example 5S, and isomeric with  
 compound of Example 12E.                                                 
 
    
     EXAMPLE 13 
     A. A solution of 1.8 g. (0.0046 mole) of 1-benzyl-3-(2-hydroxy-2-propyl)-5α-methyl-7-methoxy-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline hydrochloride was dissolved in 100 ml. of mesitylene and the solution treated with 3.8 ml. (0.1 mole) of formic acid and refluxed and stirred for about twenty-four hours. On cooling, the mixture was extracted with three 5 ml. portions of 1 M phosphoric acid, and the combined aqueous extracts washed twice with diethyl ether and then basified by the cautious addition of 6.6 g. of potassium hydroxide pellets. The oil which separated was extracted with diethyl ether, and the ether extracts worked up in the usual manner to give an oil which was converted to the hydrochloride salt. The latter was recrystallized from ethanol/ether to give 0.3 g. of 3-benzyl-6(eq)-methyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-2-butenyl)-2,6-methano-3-benzazocine hydrochoride, m.p. 232°-235° C. 
     B. Following a procedure similar to that described in Example 13A 19.6 g. (0.062 mole) of 1-methyl-3-(2-hydroxy-2-propyl)-5α-methyl-7-methoxy-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline in 1 liter of mesitylene and 38 ml. of formic acid was heated and stirred under reflux for twenty-four hours and worked up in the manner described in Example 13A to give 8.5 g. (0.028 mole) of 3,6(eq)-dimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-2-butenyl)-2,6-methano-3-benzazocine as an oil which, without further chracterization, was cleaved with 0.15 mole of sodium propylsulfide in 75 ml. of DMF using the procedure described in Example 9A. The product was converted to the methanesulfonate salt which was recrystallized from ethanol to give 1.6 g. of 3,6(eq)-dimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-methyl-2-butenyl)-2,6-methano-3-benzazocine methanesulfonate, m.p. 226°-229° C. 
     Following a procedure similar to that described in Example 13A, using an appropriate 7-R 2  -1-R 1  -3-C(R 5 )(R 6 )OR 7  -4aα-R 3  -5α-R 4  -1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline in refluxing mesitylene/formic acid, there are obtained the respective 8-R 2  -6(eq)-R 4  -1,2,3,4,5,6-hexahydro-3-R 1  -11(ax)R 3  -11(eq)-(2-lower-alkenyl)-2,6-methano-3-benzazocines of formula I in Table 13 where, in each instance, R 2  &#39;, R 2  &#34;, R 2  &#39;&#34; and R 8  are hydrogen, and Z is --CH═CR 5  R 6 . 
     
                       TABLE 13                                                    
______________________________________                                    
Example R.sub.1       R.sub.2                                             
                             R.sub.3                                      
                                  R.sub.4                                 
                                       R.sub.5                            
                                            R.sub.6                       
______________________________________                                    
13C     CH.sub.3      H      H    C.sub.3 H.sub.7                         
                                       CH.sub.3                           
                                            CH.sub.3                      
13D     CH.sub.3      H      H    C.sub.2 H.sub.5                         
                                       CH.sub.3                           
                                            CH.sub.3                      
13E     CH.sub.3      H      H    CH.sub.3                                
                                       CH.sub.3                           
                                            CH.sub.3                      
13F     CH.sub.3      HO     H    C.sub.2 H.sub.5                         
                                       CH.sub.3                           
                                            CH.sub.3                      
13G     cyclopropyl-CH.sub.2                                              
                      H      H    C.sub.2 H.sub.5                         
                                       CH.sub.3                           
                                            CH.sub.3                      
13H     C.sub.6 H.sub.5 CH.sub.2 CH.sub.2                                 
                      H      H    C.sub.2 H.sub.5                         
                                       CH.sub.3                           
                                            CH.sub.3                      
13J     CH.sub.3      H      H    C.sub.2 H.sub.5                         
                                       CH.sub.3                           
                                            C.sub.3 H.sub.7               
13K     CH.sub.3      H      CH.sub.3                                     
                                  C.sub.2 H.sub.5                         
                                       CH.sub.3                           
                                            CH.sub.3                      
13L     CH.sub.3      H      H    C.sub.2 H.sub.5                         
                                       CH.sub.3                           
                                            H                             
______________________________________                                    
 
    
     EXAMPLE 14 
     A. To a solution of 0.042 mole of diisopropylamide in hexane (prepared from 16.8 ml. of a 2.5 M solution of butyl lithium in hexane and 4.2 g. of diisopropylamine) was added a solution of 2.72 g. (0.02 mole) of phenylacetic acid in 200 ml. of tetrahydrofuran (THF) over a twenty minute period while maintaining the temperature at 0° to -5° C. The mixture was stirred for about one hour at 0° C. and then treated with a solution of 3.45 g. (0.01 mole) of ethyl β-[3,6(eq),11(ax)-trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-11(eq)-yl]propionate in 25 ml. of THF. The mixture was stirred at ambient temperature for about two hours, the solvent removed in vacuo and the residual gum was treated with 30 ml. of dilute hydrochloric acid and 75 ml. of water. The mixture was refluxed with stirring for about an hour, poured onto ice, basified with 10% sodium hydroxide and extracted three times with ether. Washing of the combined extracts with saturated brine, drying over anhydrous magnesium sulfate and evaporation to dryness afforded 4.0 g. of an oil which was dissolved in acetone and treated with a solution of methanesulfonic acid in acetone. There was thus obtained 2.2 g. of 3,6(eq),11(ax)-trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3 oxo-4-phenylbutyl)-2,6-methano-3-benzazocine methanesulfonate, m.p. 189°-192° C. 
     B. Following a procedure similar to that described in Example 14A, 6.5 g. (0.043 mole) of 3-methylphenylacetic acid was reacted with 0.096 mole of diisopropylamide (prepared from 47 ml. of a 2.0 M solution of n-butyl lithium in hexane and 9.6 g. of diisopropylamine) and the resulting lithio salt reacted with 7.5 g. (0.022 mole) of ethyl β-[3,6(eq),11(ax)-trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-11(eq)-yl]propionate in 400 ml. of THF. The product was isolated in the form of the free base to give 7.4 g. of 3,6(eq),11(ax)-trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-[3-oxo-4-(3-methylphenyl)butyl]-2,6-methano-3-benzazocine as an oil. A small amount was converted to the hydrochloride salt which, on repeated recrystallization from methanol/ether, afforded material having m.p. 180°-181° C. 
     EXAMPLE 15 
     A solution of 5.0 g. (0.013 mole) of 3,6(eq),11(ax)-trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine hydrochloride, 1.25 g. (0.017 mole) of hydroxylamine hydrochloride and 1.25 g. of sodium acetate in 50 ml. of ethanol and 10 ml. of water was heated on a steam bath for thirty minutes. The mixture was then cooled to room temperature and diluted with 100 ml. of water and the solid which separated was collected and dried to give 4 g. of crude product which was boiled with toluene for about an hour and then collected and dried to give 3.0 g. of 3,6(eq),11(ax)-trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine oxime hydrochloride, m.p. 214°-216° C. 
     EXAMPLE 16 
     A. A solution of 6.9 g. (0.018 mole) of 3,6(eq),11(ax)-trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine hydrochloride, 2.1 g. (0.019 mole) of O-carboxymethylhydroxylamine hemihydrochloride and 5.2 g. (0.038 mole) of sodium acetate in 100 ml. of ethanol and 30 ml. of water was refluxed for about twelve hours, diluted with 50 ml. of hot water, and the solid which separated was collected and dried to give 5.5 g. of 3,6(eq),11(ax)-trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine O-carboxymethyloxime hydrate. 
     B. Following a procedure similar to that described in Example 16A, 7.96 g. (0.02 mole) of 3,6(eq),11(ax)-trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxo-6-methylheptyl)-2,6-methano-3-benzazocine hydrochloride was reacted with 2.4 g. (0.02 mole) of carboxymethylhydroxylamine hemihydrochloride in 100 ml. of ethanol and 30 ml. of water in the presence of 6.0 g. of sodium acetate to give 6.5 g. of 3,6(eq),11(ax)-trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxo-6-methylheptyl)-2,6-methano-3-benzazocine O-carboxymethyloxime hydrate. 
     The preparation of the compounds of Formula I using the process of Lewis and Michne U.S. Pat. No. 4,119,628 and c.i.p. thereof, U.S. Pat. No. 4,148,794 is illustrated by the following preparations in Examples 17A-17AG, inclusive. 
     EXAMPLE 17 
     A. A solution of 24.5 g. (0.056 mole) of ethyl 3-(1-oxo-3-cyclopropylpropyl)-7-methoxy-1,4aα,5α-trimethyl-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline-3-carboxylate in a solution of 1120 ml. of mesitylene and 42 ml. of formic acid was stirred and refluxed at 117° C. for twenty-four hours. The mixture was extracted with 420 ml. of water and 60 ml. of dilute hydrochloric acid, the organic layer washed with water, and the combined aqueous layers extracted once with diethyl ether and basified with 35% sodium hydroxide. Extraction of the aqueous layer with diethyl ether, washing the ether extracts first with water, then with brine, drying and evaporation to dryness afforded 5.3 g. of an oil which was dissolved in ethanol and treated with ethereal hydrogen chloride. There was thus obtained 4.6 g. of 3,6(eq),11(ax)-trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxo-5-cyclopropylpentyl)-2,6-methano-3-benzazocine hydrochloride, m.p. 224°-226° C. 
     Following a procedure similar to that described in Example 17A, using an appropriate lower-alkyl 1-R 1  -3-R 5  CO-4aα-R 3  -5α-R 4  -7-R 2  -1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline-3-carboxylate of formula IX, which are described in Lewis and Michne U.S. Pat. No. 4,119,628 and c.i.p. thereof U.S. Pat. No. 4,148,794, there were prepared the 3-R 1  -6(eq)-R 4  -11(ax)-R 3  -1,2,3,4,5,6-hexahydro-11(eq)-CH 2  CH 2  COR 5  -2,6-methano-3-benzazocines of formula I in Table 17 where, in each instance, R 2  &#39;, R 2  &#34; and R 2  &#39;&#34; are hydrogen and Z is CH 2  COR 5 . The Example numbers where the alternative preparations of the same species from the 7-R 2  -1-R 1  -3-COR 5  -4aα-R 3  -5α-R 4  -1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinolines of formula II have been described above are given in parentheses in the column headed &#34;Example&#34;. The reaction conditions used, that is procedure A described in Example 1A using trimethylammonium formate or procedure B described in Example 1B using formic acid in refluxing mesitylene, are also indicated in the column headed &#34;Example&#34; by the respective designations A and B. 
     
                                           TABLE 17                                
__________________________________________________________________________
                          Wt. S.M.                                        
                                  M.P. (°C.)                       
Example                                                                   
       R.sub.1 /R.sub.2                                                   
            R.sub.3 R.sub.4                                               
                R.sub.5   Wt. Prod.                                       
                                  Solv.                                   
__________________________________________________________________________
17B(1AA)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                CH.sub.3  57.1 (base)                                     
                                  183-186                                 
B      CH.sub.3 O                                                         
            CH.sub.3      6.6(HCl)                                        
                                  ethanol/ether                           
17C(1U)                                                                   
       C.sub.6 H.sub.5 CH.sub.2                                           
            CH.sub.3                                                      
                (CH.sub.2).sub.4 CH.sub.3                                 
                          139.9 (base)                                    
                                  223-227                                 
B      CH.sub.3 O                                                         
            CH.sub.3      35.9 (HCl)                                      
                                  ethanol/ether                           
17D(1AB)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                (CH.sub.2).sub.4 (CH.sub.3                                
                          24.1 (base)                                     
                                  oil (b)                                 
B      H    CH.sub.3      17.8 (base)                                     
17E(1AR)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                (CH.sub.2).sub.4 CH.sub.3                                 
                          7.0 (base)                                      
                                  225-227.5                               
B      CH.sub.3 O                                                         
            C.sub.2 H.sub.5                                               
                          4.1 (HCl)                                       
                                  acetone/ether                           
17F(1AC)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                (CH.sub.2).sub.2 CH(CH.sub.3).sub.2                       
                          27.9 (base)                                     
                                  oil (c)                                 
B      H    CH.sub.3      20.7 (base)                                     
17G(1AS)                                                                  
       C.sub.6 H.sub.5 CH.sub.2                                           
            CH.sub.3                                                      
                (CH.sub.2).sub.2 CH(CH.sub.3).sub.2                       
                          75.9 (base)                                     
                                  oil                                     
B      CH.sub.3 O                                                         
            CH.sub.3      57.1 (base)                                     
17H(1AD)                                                                  
       CH.sub.3                                                           
            H   (CH.sub.2).sub.2 CH(CH.sub.3).sub.2                       
                          28.3 (base)                                     
                                  159-162.5 (d)                           
B      CH.sub.3 O                                                         
            CH.sub.3      9.8 (oxalate)                                   
                                  ethanol/ether                           
17J(1AT)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                (CH.sub.2).sub.2 CH(CH.sub.3).sub.2                       
                          31.2 (base)                                     
                                  250-252                                 
B      CH.sub.3 O                                                         
            C.sub.2 H.sub.5                                               
                          7.3 (HCl)                                       
                                  ethanol/ether                           
17K(1AF)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                (CH.sub.2).sub.3 CH(CH.sub.3).sub.2                       
                          23.7 (base)                                     
                                  197-200                                 
B      CH.sub.3 O                                                         
            CH.sub.3      8.2 (HCl)                                       
                                  ethanol/ether                           
17L(1AE)  B                                                               
       CH.sub.3 CH.sub.3 O                                                
             ##STR46##                                                    
                (CH.sub.2).sub.2 CH(CH.sub.3).sub.2                       
                          13.5 (base) 6.6 (HCl)(1/2 H.sub.2 O)            
                                  169-173 ethanol/ether                   
17M(1AH)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                CH.sub.2 cyclobutyl                                       
                          20 (base)                                       
                                  oil (e)                                 
A      CH.sub.3 O                                                         
            CH.sub.3      8.9 (base)                                      
17N(1AJ)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                (CH.sub.2).sub.2 cyclopentyl                              
                          43.7 (base)                                     
                                  219-223                                 
B      CH.sub.3 O                                                         
            CH.sub.3      19.5 (HCl)                                      
                                  ethanol/ether                           
17P(1AK)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                (CH.sub.2).sub.2 cyclopentyl                              
                          20.6 (base)                                     
                                  231-235 (a)                             
B      H    CH.sub.3      8.5 (H.sub.2 SO.sub.4)                          
                                  ethanol/ether                           
17Q(1AM)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                C.sub.6 H.sub.5                                           
                          21.6 (base)                                     
                                  94-97                                   
B      H    CH.sub.3      6.0 (base)                                      
                                  ethanol                                 
17R(1AN)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                C.sub.6 H.sub.5                                           
                          35.2 (base)                                     
                                  102-106                                 
B      CH.sub.3 O                                                         
            CH.sub.3      14.8 (base)                                     
                                  ethanol                                 
17S(1AP)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                C.sub.6 H.sub.4 H.sub.3 (3)                               
                          12.6 (base)                                     
                                  94-96                                   
A      CH.sub.3 O                                                         
            CH.sub.3      6.9 (base)                                      
                                  methanol                                
17T(1AQ)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                C.sub.6 H.sub.4 CH.sub.3 (4)                              
                          4.0 (base)                                      
                                  87-89                                   
A      CH.sub.3 O                                                         
            CH.sub.3      2.1 (base)                                      
                                  methanol                                
17U(1AV)                                                                  
       CH.sub.3                                                           
            CH.sub.3                                                      
                (CH.sub.2).sub.2 cyclobutyl                               
                          12.4 (base)                                     
                                  153-155                                 
A      CH.sub.3 O                                                         
            CH.sub.3      8.3 (CH.sub.3 SO.sub.3 H)                       
                                  acetone/                                
                                  ether                                   
17V    CH.sub.3                                                           
            CH.sub.3                                                      
                CH(CH.sub.3).sub.2                                        
                          10.0 (base)                                     
                                  211-214                                 
A      CH.sub.3 O                                                         
            CH.sub.3      5.6 (CH.sub.3 SO.sub.3 H)                       
                                  acetone                                 
17W    CH.sub.3                                                           
            CH.sub.3                                                      
                cyclopentyl                                               
                          11.5 (base)                                     
                                  138-141                                 
A      CH.sub.3 O                                                         
            CH.sub.3      7.3 (CH.sub.3 SO.sub.3 H)                       
                                  acetone/                                
                                  ether                                   
17X    CH.sub.3                                                           
            CH.sub.3                                                      
                (CH.sub.2).sub.2 cyclobutyl                               
                          12.4 (base)                                     
                                  153-155                                 
A      CH.sub.3 O                                                         
            CH.sub.3      8.3 (CH.sub.3 SO.sub.3 H)                       
                                  acetone/                                
                                  ether                                   
17Y    CH.sub.3                                                           
            CH.sub.3                                                      
                CH.sub.2 cyclobutyl                                       
                          20 (base)                                       
                                  166-168                                 
A      CH.sub.3 O                                                         
            CH.sub.3      5.2 (CH.sub.3 SO.sub.3 H)                       
                                  acetone/                                
                                  ether                                   
17Z    C.sub.6 H.sub.5 CH.sub.2                                           
            CH.sub.3                                                      
                (CH.sub.2).sub.2 CH(CH.sub.3).sub.2                       
                          52 (base)                                       
                                  228-230                                 
A      CH.sub.3 O                                                         
            CH.sub.3      22.5 (HCl)                                      
                                  ethanol                                 
17AA   C.sub.6 H.sub.5 CH.sub.2                                           
            CH.sub.3                                                      
                (CH.sub.2).sub.4 CH.sub.3                                 
                          96.8 (base)                                     
                                  oil                                     
       CH.sub.3 O                                                         
            CH.sub.3      75.3 (base)                                     
17AB   CH.sub.3                                                           
            CH.sub.3                                                      
                cyclopropyl                                               
                          47.7 (base)                                     
                                  128.5-121.5                             
A      CH.sub.3 O                                                         
            CH.sub.3      3.6 (base)                                      
                                  ethanol                                 
17AC   CH.sub.3                                                           
            C.sub.2 H.sub.5                                               
                (CH.sub.2).sub.2 CH(CH.sub.3).sub.2                       
                          50.4 (base)                                     
                                  220-221                                 
A      CH.sub.3 O                                                         
            C.sub.2 H.sub.5                                               
                          2.0 (HCl)                                       
                                  acetone/                                
                                  ether                                   
17AD   CH.sub.3                                                           
            C.sub.2 H.sub.5                                               
                (CH.sub.2).sub.4 CH.sub.3                                 
                          41.5 (base)                                     
                                  198-199                                 
B      CH.sub.3 O                                                         
            C.sub.2 H.sub.5                                               
                          6.9 (HCl)                                       
                                  ethanol/                                
                                  ether                                   
17AE A CH.sub.3 CH.sub.3 O                                                
             ##STR47##                                                    
                (CH.sub.2).sub.4 CH.sub.3                                 
                          49.1 (base) 19.3 (base)                         
                                  oil                                     
17AF   CH.sub.3                                                           
            C.sub.2 H.sub.5                                               
                (CH.sub.2).sub.4 CH.sub.3                                 
                          42.3 (base                                      
                                  164-167                                 
A      CH.sub.3 O                                                         
            CH.sub.3      2.1 (p-tosylate)                                
                                  ethanol/                                
                                  ether                                   
17AG   CH.sub.3                                                           
            CH.sub.3                                                      
                CH.sub.2 cyclopentyl                                      
                          70.9 (base)                                     
                                  242-245                                 
B      CH.sub.3 O                                                         
            CH.sub.3      37.3 (HCl)                                      
                                  ethanol/ether                           
__________________________________________________________________________
 (a) The free base was obtained as an amber oil.                          
 (b) The H.sub.2 SO.sub.4 salt gave m.p. 191-193° C.               
 (c) The H.sub.2 SO.sub.4 salt gave m.p. 190-196° C.               
 (d) The ptosylate salt gave m.p. 131-135° C.                      
 (e) The methaneuslfonate gave m.p. 166-168° C.                    
 
    
     The β-keto esters of formula IX, which are required as starting materials for each of Examples 17AB through 17AG are not specifically disclosed in U.S. Pat. No. 4,148,794. The species required for Examples 17AB through 17AG were prepared according to the procedure described in U.S. Pat. No. 4,148,794 by reaction of an appropriate ethyl 7-methoxy-1-methyl-4aα-R 3  -5α-R 4  -1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline-3-carboxylate with lithium diisopropylamide in tetrahydrofuran and reaction of the resulting lithium salt with an appropriate acid chloride (R 3  COCl). These β-keto esters of formula IX used as starting materials for Examples 17AB through 17AG are given in Examples 17ABa through 17AGa, respectively, in Table 17a below where the values for R 1 , R 2 , R 3 , R 4  and R 5  have the corresponding meanings given in Table 17 above, and where the weights of starting materials are given for the ethyl 7-methoxy-1-methyl- 4aα-R 3  -5α-R 4  -1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline-3-carboxylate. 
     
                       TABLE 17a                                                   
______________________________________                                    
Example     Wt. S.M.      Wt. Prod.                                       
______________________________________                                    
17ABa       60.0          51.2 (base)-oil                                 
17ACa       50.0          50.4 (base)-oil                                 
17ADa       42.0          41.5 (base)-oil                                 
17AEa       47.8          51.0 (base)-oil                                 
17AFa       40.0          42.3 (base)-oil                                 
17AGa       60.0          70.9 (base)-oil                                 
______________________________________                                    
 
    
     EXAMPLE 17AH-17AL 
     Certain species of the compounds of formula I were prepared by reaction of ethyl 3-[8-methoxy-3,6(eq),11(ax)trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-11(eq)-yl]propionate (hereinafter referred to as the &#34;propionate ester&#34;) with a twenty molar percent excess of lithium diisopropylamide (prepared by reaction of butyl lithium wit diisopropylamine) and reaction of the resulting lithium salt with a molar excess of an appropriate acid chloride, followed by decarboxylation of the resulting β-keto ester by heating the latter, as before, in trimethylammonium formate. There were thus prepared the following compounds of formula I: 
     Example 17AH--3,6(eq),11(ax)-Trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(4,4-dimethyl-3-oxooctyl)-2,6-methano-3-benzazocine picrate (3.0 g., m.p. 136°-139° C. from ethanol) prepared by reacting 9.6 g. (0.028 mole) of the propionate ester with 0.033 mole of lithium diisopropylamide in 200 ml. of tetrahydrofuran; reacting the resulting lithium salt with 7.9 g. (0.049 mole) of α,α-dimethylhexanoyl chloride; and boiling a solution of 5.2 g. (0.011 mole) of the resulting β-keto ester in 25 ml. of trimethylammonium formate for twelve minutes; 
     Example 17AJ--3,6(eq),11(ax)-Trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(4,4-dimethyl-3-oxohexyl)-2,6-methano-3-benzazocine methanesulfonate (3.1 g., m.p. 200°-202° C. from acetone) prepared by reacting 14.1 g. (0.041 mole) of the propionate ester with 0.052 mole of lithium diisopropylamide in 275 ml. of tetrahydrofuran; reacting the resulting lithium salt with 8.2 g. (0.061 mole) of α,α-dimethylbutyryl chloride; and boiling a solution of 20.5 g. of the resulting β-keto ester in 100 ml. of trimethylammonium formate for eighteen minutes; 
     Example 17AK--3,6(eq),11(ax)-Trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(4,4-dimethyl-3-oxoheptyl)-2,6-methano-3-benzazocine picrate (10.7 g., m.p. 183°-187° C. from ethanol) prepared by reacting 15.8 g. (0.046 mole) of the propionate ester with 0.055 mole of lithium diisopropylamide in 400 ml. of tetrahydrofuran; reacting the resulting lithium salt with 11.6 g. (0.078 mole) of α,α-dimethylpentanoyl chloride; and boiling a solution of 19.8 g. (0.046 mole) of the resulting β-keto ester in 100 ml. of trimethylammonium formate. 
     Example 17AL--3,6(eq),11(ax)-Trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-cyclopropyl-3-oxopropyl)-2,6-methano-3-benzazocine (8.0 g. as an oil) prepared by reaction of 5.5 g. (0.015 mole) of ethyl 3-[8-methoxymethoxy-3,6(eq),11(ax)-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-11(eq)-yl]propionate with 0.018 mole of lithium diisopropylamide in 150 ml. of tetrahydrofuran; reacting the resulting lithium salt with 2.8 g. (0.027 mole) of cyclopropanecarboonyl chloride; and boiling the resulting β-keto ester in 70 ml. of trimethylammonium formate. 
     EXAMPLE 18 
     A mixture of about 0.047 mole of methyl β-[3,6(eq),11(ax)-trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-11(eq)-yl]propionate, 350 ml. of methylene dichloride, 125 ml. of dimethoxymethane and 0.5 ml. of ethanesulfonic acid was heated under reflux under a Soxhlet extractor containing 4A molecular sieves for twenty-seven hours. The reaction mixture was then filtered into a mixture of 50 ml. of 2.5 N sodium hydroxide and 250 g. of ice, and the solid which separated was collected and air-dried to give 10.4 g. of recovered starting material. The filtrate was extracted two times with methylene dichloride, and the combined extracts, on drying and evaporation to dryness, afforded 9.2 g. of methyl β-[3,6(eq),11(ax)-trimethyl-8-methoxymethoxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-11(eq)-yl]propionate as an oil. 
     A solution of the latter (5.5 g., 0.015 mole) in 150 ml. of tetrahydrofuran (THF) was added to a solution of lithium diisopropylamide [prepared from 7.9 ml. of a 2.3 M solution of butyl lithium and 1.8 g. (0.018 mole) of diisopropylamine in tetrahydrofuran] while maintaining the temperature at -70° C., and the mixture was stirred for thirty minutes. The resulting solution was treated with a solution of 2.8 g. (0.027 mole) of cyclopropanecarbonyl chloride in THF added over a period of one minute. The solution was then stirred for thirty minutes and poured into 200 ml. of saturated aqueous sodium bicarbonate. The mixture was extracted with diethyl ether, and the ether extracts were washed with saturated sodium chloride, dried over anhydrous magnesium sulfate and evaporated to dryness to give 8 g. of an oil which was boiled for eleven minutes with 10 ml. of trimethylammonium formate. The mixture was concentrated to about 35 ml. in vacuo, and the residue was suspended in water, the pH adjusted to 8.0 and extracted with methylene dichloride. Work-up of the organic extracts as before afforded 5.1 g. of an oil which was suspended in 100 ml. of ethanol and 10 ml. of 5% potassium hydroxide and refluxed overnight. The mixture was again adjusted to pH 8, concentrated uner reduced pressure and extracted again with methylene dichloride. Evaporation of the extracts to dryness afforded 4.0 g. of crude product which was converted to the methanesulfonate which, on recrystallization from isopropanol, afforded 1.8 g. of 3,6(eq),11(ax)-trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-cyclopropyl-3-oxopropyl)-2,6-methano-3-benzazocine methanesulfonate, m.p. 213°-215° C. 
     EXAMPLE 19 
     A solution of 5.0 g. (0.015 mole) of ethyl β-[3,6(eq),11(ax)-trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-11(eq)-yl]propionate in 25 ml. of toluene was cooled in an acetone/dry ice bath and treated with 10 mkl. of a 1.6 M solution of t-butyl lithium in pentane over a period of about thirty minutes under a nitrogen atmosphere. The mixture was then stirred for an additional thirty minutes, allowed to warm to ambient temperature and then poured into a solution containing 50 g. of ammonium chloride in 100 ml. of water. The mixture was extracted two times with ether, the combined extracts were washed with saturated brine, dried over magnesium sulfate and evaporated to dryness to give 6 g. of an oil which was refluxed in a solution of 50 ml. of ethanol and 50 ml. of 5% potassium hydroxide for about forty-eight hours. Extraction of the mixture with ether and work-up of the ether extracts as before afforded 5.3 g. of an oil which was dissolved in acetone and treated with methanesulfonic acid to give 2.4 g. of 3,6(eq),11(ax)-trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-(4,4-dimethyl-3-oxopentyl)-2,6-methano-3-benzazocine methanesulfonate, m.p. 174-176. 
     EXAMPLE 20 
     Following a procedure similar to that described in Example 18, 15.4 g. (0.045 mole) of ethyl β-[3,6(eq),11(ax)trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-11(eq)-yl]propionate was converted to the lithium salt by reaction of the former with a slight molar excess of lithium diisopropylamide in THF, and the resulting lithium salt was treated with 12.9 g. (0.078 mole) of 1-bromohexane. There was thus obtained 14.9 g. of ethyl α-hexyl-β-[3,6(eq),11-(ax)-trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-11(eq)-yl]propionate as an oil. The picrate salt gives m.p. 175°-177° C. (from ethanol). 
     The latter (7.0 g., 0.016 mole), dissolved in 60 ml. of THF, was added to a solution of 20 ml. of a 1.9 M solution of methyl lithium in diethyl ether under a nitrogen atmosphere while maintaining the temperature at 0° C. When addition was complete the mixture was stirred at ambient temperature for four hours, then poured into aqueous bicarbonate, and the mixture extracted with diethyl ether. Isolation of the product from the ether extracts as before afforded 7.8 g. of 3,6(eq),11(ax)-trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-{3-[2-(2-hydroxy)propyl]octyl}-2,6-methano-3-benzazocine as an oil. The methanesulfonate gave m.p. 164°-166° C. (from acetone). 
     The latter (3.2 g., 0.006 mole) was cleaved with sodium propylsulfide in 100 ml. of DMF using the procedure described above in Example 9A. The product was isolated in the form of the methanesulfonate to give 1.6 g. of 3,6(eq),11(ax)-trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq){3-[2(2-hydroxy)propyl]octyl}-2,6-methano-3-benzazocine methanesulfonate, m.p. 192°-195° C. (from methanol). 
     EXAMPLE 21 
     A mixture of 3.3 g. (0.008 mole) of 3,6(eq),11(ax)-trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq){3-[2-(2-hydroxy)propyl]octyl}-2,6-methano-3-benzazocine (described in Example 20) in 10 ml. of acetic anhydride containing 0.8 g. of methanesulfonic acid was boiled for ten minutes, then concentrated to a small volume, basified with aqueous sodium hydroxide, boiled for several more minutes, then cooled, extracted and the dried extracts taken to dryness to give 3.2 g. of an oil which was dissolved in acetone and treated with methanesulfonic acid. There was thus obtained, after several recrystallizations from acetone, 1.2 g. of 3,6(eq),11(ax)-trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-{2[2-(1-propenyl)]octyl}-2,6-methano-3-benzazocine methanesulfonate, m.p. 176°-178° C. 
     EXAMPLE 22 
     A mixture containing 1.6 g. of a 50% mineral oil suspension of sodium hydride (0.033 mole) in 30 ml. of dimethylsulfoxide (DMSO) was heated at 70°-80° C. until no further gas was given off. The mixture was then cooled to ambient temperature, treated with 11.7 g. (0.033 mole) of methyl tripheenyl phosphonium bromide in 35 ml. of DMSO, and the mixture was stirred for one-half hour at ambient temperature. The mixture thus prepared was treated with a solution of 8.0 g. (0.022 mole) of 3,6(eq),11(ax)-trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-6-methyl-3-oxo-heptyl)-2,6-methano-3-benzazocine in 35 ml. of DMSO, and the mixture was stirred at ambient temperature under a nitrogen atmosphere for about forty-eight hours and then poured into 200 ml. of water. The resulting mixture was extracted three times with water, washed with saturated brine, dried over magnesium sulfate and concentrated to dryness to give a waxy solid, which was dissolved n a 60:40:2 mixture of hexane:ether:isopropanol and chromatographed on 200 g. of an activated silica gel column, the product being eluted with the same solvent system. The first 300 ml. of eluate were discarded, and the next 1,200 ml. were combined and taken to dryness to give 3.5 g. of 3,6(eq),11(ax)-trimethyl-8-methoxy-1,2,3,4,5,6-hexahydro-11(eq)-[3-(3-methylbutyl)-3-butenyl]-2,6-methano-3-benzazocine. 
     The latter was cleaved with 0.048 mole of sodium propylsulfide in 70 ml. of DMF using the procedure described above in Example 9A. The product was isolated in the form of the methanesulfonate to give 2.4 g. of 3,6(eq),11(ax)-trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-[3-(3-methylbutyl)-3-butenyl]-2,6-methano-3-benzazocine methanesulfonate, m.p. 231°-235° C. 
     EXAMPLE 23 
     A solution of 3.0 g. (0.0064 mole) of 3,6(eq),11(ax)-trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine ethanesulfonate and 1.5 ml. of acetic anhydride in 25 ml. of pyridine was stirred at ambient temperature for three and one-half hours, then poured into a mixture of 100 ml. of ether and 100 ml. of dilute sodium hydroxide. The organic layer was separated, the aqueous layer was extracted twice with ether, and the combined ether extracts were washed twice with water, dried over magnesium sulfate and taken to dryness to give 2.7 g. of a gum, which was dissolved in acetone and treated with a molar excess of methanesulfonic acid. Several recrystallizations of the resulting solid from acetone/ether afforded 2.0 g. of 3,6(eq),11(ax)-trimethyl-8-acetoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine methanesulfonate, m.p. 189°-190° C. 
     EXAMPLE 24 
     Following a procedure similar to that described in Example 18, a solution of 4.2 g. (0.004 mole) of 3,6(eq),11(ax)trimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl-2,6-methano-3-benzazocine in 4.0 ml. of dimethoxymethane and 65 ml. of methylene dichloride containing a catalytic amount of ethanesulfonic acid was refluxed under a Soxhlet extractor containing 4A molecular sieves and the product isolated in the form of the free base to give 1.75 g. of 3,6(eq),11(ax)trimethyl-8-methoxymethoxy-1,2,3,4,5,6-hexahydro-11(eq)-(3-oxooctyl)-2,6-methano-3-benzazocine as a waxy solid, m.p. 46°-48° C. 
     BIOLOGICAL TEST RESULTS 
     The compounds of formula I are generally active in the acetylcholine-induced abdominal constriction test (Ach), a primary analgesic screening test, and also in either the rat tail flick radiant thermal heat analgesic test (Tail Flick Agon.) or the rat tail flick phenazocine antagonist test (Phen.). Some of the species have also been tested and found active in the phenyl-p-quinone-induced writhing (PPQ) and anti-bradykinin (BK) tests, which are also primary analgesic screening procedures. 
     Data so obtained for the compounds, identified by reference to the preceding examples and expressed either in terms of the ED 50  (mg./kg., subcutaneous administration) or in terms of percent inhibition, are given below. Where more than one form of a given species has been described in the examples, such as the free base, or a particular salt form or a d- or 1-form, if resolution into optical isomers was carried out, the compounds are so-identified along with the example number. 
     The finding of inactivity in a given test is indicated by the letter I. All doses are expressed in milligrams per kilogram (mg./kg.). 
     
         __________________________________________________________________________
                                   Tail Flick                             
Example   Ach  Phen.  PPQ  BK      Agonist                                
__________________________________________________________________________
1A        1.7  I      --   --      14 ± 2                              
1B        0.3  I      --   --      6.9 ± 0.8                           
1C        1.1  --     --   --      11 ± 1.0                            
1D        7.4  24     64%/50                                              
                           --      I                                      
1H        18   I      --   40%/10  I/240                                  
1M        1.9  I      --   --      5.9 ± 0.95                          
1N        0.89 I      --   --      2.0 ± 0.22                          
1P        87%/75                                                          
               7.8    --   --      I                                      
          33%/25                                                          
10        ˜6.9                                                      
               I      --   --      16%/120                                
                                   14%/10                                 
1S        1.0  I      --   --      4.3 ± 0.52                          
1U        53%/75                                                          
               I      --   --      I                                      
          43%/25                                                          
          7%/7.5                                                          
1V        2.0  I      --   2.4     16 ± 3.3                            
1W        60%/75                                                          
               I      --   --      I                                      
          20%/25                                                          
1Y        0.63 I      --   --      1.35                                   
1Z        11   21     --   --      I                                      
1AA,17B   3.5  --     --   --      66%/120                                
1AB,17D   ˜1.9                                                      
               I/1.0,10,80                                                
                      --   --      16                                     
1AC,17F   ˜1.3                                                      
               I/1.0,10,80                                                
                      --   --      15                                     
1AD,17H   11   I/80   --   --      13%/120                                
1AE,17L   1.2  I/80   --   --      31                                     
1AF,17K   7.5  I/80   --   --      70%/120                                
                                   24%/60                                 
                                   9%/30                                  
1AG,17A   1.3  I/80   --   --      9.4                                    
1AH       ˜0.71                                                     
               I/1.0  --   --      2.6                                    
1AJ,17N   10   26%/80 --   --      33%/240                                
                                   12%/120                                
1AK,17P(H.sub.2 SO.sub.4)                                                 
          5.6  I/80   --   28      16%/120                                
1AK (base)                                                                
          60%/75                                                          
               I/80   --   --      I/120,240                              
          47%/25                                                          
          33%/10                                                          
1AL,14A   ˜0.22                                                     
               I/0.1-1.0,10                                               
                      --   --      0.86                                   
1AM,17Q   0.081                                                           
               I/0.1-1.0,10                                               
                      --   --      0.28                                   
1AN,17R   0.025                                                           
               I/0.01-0.1                                                 
                      --   --      0.18                                   
1AP,17S   0.24 I/0.1  --   --      0.46                                   
1AQ,17T   0.90 I/0.1  --   --      1.5                                    
1AV       5.6  I/80   --   I/10    19%/60                                 
                           80%/20  48%/120                                
                                   43%/240                                
2B        1.4  I      --   0.24    42 ± 21                             
2C        ˜0.18                                                     
               I      --   --      0.99 ± 0.14                         
2D        0.023                                                           
               I      --   --      0.099 ± 0.014                       
2E        0.19 I      --   --      0.95 ± 0.11                         
2F(d,l-HCl)                                                               
          0.074                                                           
               0.30   0.018                                               
                           0.032   47%/240                                
2F(d-HCl) 13%/10                                                          
               I      --   --      I                                      
          27%/1.0                                                         
          27%/0.5                                                         
2F(1-HCl) 0.016                                                           
               ˜0.088                                               
                      --   --      9%/120                                 
2F(d,l-CH.sub.3 SO.sub.3 H)                                               
          0.049                                                           
               --     --   --      --                                     
2G        12   0.04   --   2.2     16                                     
2H(d,l-HCl)                                                               
          0.24 0.008 (a)                                                  
                      0.28 0.043   I                                      
          26(p.o.)                                                        
               7.8(p.o.)                                                  
2H(d,l-CH.sub.3 SO.sub.3 H)                                               
          0.23 --     --   --      --                                     
2H(1-CH.sub.3 SO.sub.3 H)                                                 
          0.74 0.005  0.052                                               
                           0.022   I/95                                   
          0.19                                                            
2H(d-CH.sub.3 SO.sub.3 H)                                                 
          6.3  I/80   5.6  I/50    I/85                                   
          ˜11                                                       
2H(napsylate)                                                             
          0.10 ˜2(i.p.)                                             
                      --   --      --                                     
2J        0.019                                                           
               I      --   --      0.067                                  
2K        0.24 I      --   --      1.5                                    
2L(CH.sub.3 SO.sub.3 H)                                                   
          8.1  0.015  --   0%/10,50                                       
                                   I                                      
2L(CH.sub. 2 H.sub.5 SO.sub.3 H)                                          
          14   I/80   --   I/100   --                                     
2M(base)  0.25 --     --   100%/0.5                                       
                                   70%/60                                 
2M(CH.sub.3 SO.sub.3 H)                                                   
          0.17 --     0.21 0.19    2.5                                    
2N        4.2  0.42   --   --      I/120                                  
2R        5.3  0.029  --   --      I/120                                  
2S        0.15 1.1    --   --      13%/120                                
2U        0.066                                                           
               0.86   --   --      59%/120                                
                                   36%/60                                 
                                   19%/30                                 
2V(d,l-H.sub. 2 SO.sub.4)                                                 
          60%/75                                                          
               0.012  --   0%/25   I/100                                  
          47%/25                                                          
2V(d-CH.sub.3 SO.sub.3 H)                                                 
          85%/75                                                          
               ˜0.43                                                
                      --   --      --                                     
          33%/25                                                          
2W        0.0012                                                          
               --     --   --      0.00135                                
2X        0.0036                                                          
               I/0.001                                                    
                      --   --      0.0046                                 
2Y        0.011                                                           
               I/0.01 --   --      0.028                                  
2Z        1.3  ˜0.004                                               
                      --   0.28    I/120                                  
2AA       8.2  0.0052 --   --      I/120                                  
2AB       11   I/80   --   0.12    11,24                                  
          22(p.o.)                 40%/60                                 
                                   58%/120                                
                                   53%/240                                
2AD       1.9  0.016  --   --      I/120                                  
2AE       0.0055                                                          
               I/0.001-1.0                                                
                      --   --      0.044                                  
2AF       0.27 0.56                20%/120                                
2AJ       0.029                                                           
               0.065  --   --      13%/1.0                                
                                   34%/1.0                                
                                   14%/40                                 
                                   21%/120                                
2AK       12   4.5    --   --      I/120                                  
2AL       4.8  1.9    --   --      I/120                                  
2AM       9.2  3.7    --   --      --                                     
3C        13   I      --   I/50    40%60(i.p.)                            
                           100%/50(i.p.)                                  
3D        2.7  I      --   --      25%/30                                 
3G(HCl)   13%/25                                                          
               I      --   --      40%/120(i.p.)                          
          13%/2.5                  33%/60(i.p.)                           
3G(base)  8.9  I/80   --   --      I/120                                  
3H        100%/75                                                         
               I      --   --      I                                      
          27%/25                                                          
3J        16   I/80   --   --      I/60,120                               
4A        8.9  0.088  --   --      I/120                                  
4C        6.9  I      --   --      64 ± 12                             
4D        5.4 I                                                           
               --     --   17%/120                                        
                                   64%/240                                
4E(HCl)   1.5  I      --   --      30 ± 7.4                            
4F        13%/75                                                          
               I      --   --      I                                      
          7%/25                                                           
4H        7%/75                                                           
               I      --   --      I                                      
          13%/25                                                          
4J        87%/75                                                          
               0.013  --   --      I/120                                  
          47%/25                                                          
4K        7.5  0.037  --   --      I/120                                  
4L        27%/75                                                          
               0.0078 --   --      I/120                                  
          27%/25                                                          
4M        5.1  0.026  --   --      I/120                                  
4N        40%/75                                                          
               0.011  --   --      I/240                                  
          27%/25                                                          
5A        1.6  I      --   --      11 ± 2.2                            
5B        2.1  I      --   --      10%/60                                 
5C        4.7  61%/80 11   --      I                                      
5D        16   0.046  21   40%/100 I                                      
                           25%/50                                         
                           40%/10                                         
5F        8.2  I      5.9  --      I                                      
5S        3.9  I/10   --   I/10    --                                     
8A        2.8  I      --   --      60 ± 6.9                            
8B        0.68 I/10   --   17      23                                     
9A        93%/75                                                          
               0.27   --   --      --                                     
          33%/25                                                          
          27%/10                                                          
9B        40%/75                                                          
               I      --   --      I                                      
          27%/25                                                          
9C        2.6  I      --   --      68 ± 14                             
9D        67%/75                                                          
               0.022  --   --      I                                      
          33%/25                                                          
          13%/1.0                                                         
9E        7.6  0.019  --   --      I                                      
9F        34   0.47   --   --      I                                      
9G(d,1-CH.sub.3 SO.sub.3 H)                                               
          8.9  0.71   --   I/28    I                                      
9G(1-CH.sub.3 SO.sub.3 H)                                                 
          3.8  0.34   --   --      I                                      
9H        100%/75                                                         
               I      --   --      I                                      
          47%/25                                                          
9J        3.8  2.3    --   7.9     I                                      
9K        0.017                                                           
               I      --   0.012   0.039 ± 0.006                       
9L        6.6  2.4    &#39;    ˜5                                       
                                   I                                      
9M        9.0  1.1    --   --      I/15                                   
9N        4.5  0.006  --   --      I                                      
9P        20%/75                                                          
               0.26   --   --      I/120(i.p.)                            
          27%/25                                                          
9Q        100%/75                                                         
               0.33   --   --      I                                      
          47%/25                                                          
9R        87%/75                                                          
               I      --   --      I                                      
          13%/25                                                          
10        33%/75                                                          
               12     --   --      I/120                                  
          13%/25                                                          
11A       6.5  0.025  --   --      I                                      
11B       7.9  0.040  --   --      I                                      
11C       3.3  I      --   --      17%/120                                
                                   43%/240                                
12A       2.5  I      --   --      56                                     
12B       1.4  26%/10(i.p.)                                               
                      --   0.70    15%/60(i.p.)                           
12C       93%/75                                                          
               0.0034 --   --      I                                      
          13%/25                                                          
12D(base) 0.023                                                           
               0.050  0.034                                               
                           0.024   --                                     
12D(HCl)  --   --     --   1.0(p.o.)                                      
                                   --                                     
13E       22   0.032  --   I/100   I/120                                  
12F       14   0.020  --   I/50    I/120                                  
13B       1.6  I      --   --      22%/120                                
                                   72%/60                                 
                                   72%/30                                 
15        2.0  0.060  --   --      I/120                                  
16A       7%/75                                                           
               I      --   --      I                                      
          13%/25                                                          
16B       7%/75                                                           
               I      --   --      --                                     
          20%/25                                                          
17V       5.0  I/80   --   4.7     12%/60                                 
                                   42%/120                                
                                   28%/240                                
17W       4.7  I/40   --   --      100                                    
17AB      2.1  I/10.0,10,80                                               
                      --   --      16                                     
17AE      1.1  I/80   --   --      36%/60                                 
17AF      0.88 I/80   --   --      26%/120                                
                                   33%/120(i.p.)                          
18        0.23 I/10                2.7                                    
22        4.3  6.8    --   8.3     I/120,240                              
23        0.38 43-63% --   0.17    I/120                                  
               0.001-0.1                                                  
__________________________________________________________________________
 (a) 0.098 mg./kg. vs. morphine                                           
 
    
     The compound of Example 2P has also been found to be active in the phenazocine tail flick antagonist test, the ED 50  (subcutaneous administration) for that species being 7.8 mg./kg. 
     In the tail flick antagonist test, the 50% effective Antagonist Doses (AD 50&#39;s ) of the narcotic antagonists, nalorphine and naloxone, are similar versus anti-agonist doses of the narcotics, morphine, meperidine and phenazocine. It has been shown that the AD 50  values of nalorphine and naloxone are about four times higher versus the compound of Example 2M (the methanesulfonate) than they are versus an equi-agonist dose of morphine. This is considered to be an indication of differences in the receptor-combining properties of the drugs. Determination of the AD 50&#39;s  of nalorphine or naloxone versus the higher homologs of the compound of Example 2M, namely the species of Examples 2C, 2D and 9K might categorize these latter species as being similar to morphine, and different from the compound of Example 2M, or vice versa.