Patent Publication Number: US-2020276160-A1

Title: Triptan Powders for Pulmonary Delivery

Description:
RELATED APPLICATION 
     This application is a continuation of U.S. application Ser. No. 16/282,791, filed Feb. 22, 2019, which is a continuation of U.S. application Ser. No. 16/026,210, filed Jul. 3, 2018, now abandoned, which is a continuation of U.S. application Ser. No. 15/200,335, filed Jul. 1, 2016, now U.S. Pat. No. 10,034,857, issued Jul. 31, 2018, which claims the benefit of U.S. Provisional Application No. 62/188,338, filed on Jul. 2, 2015. The entire teachings of the above applications are incorporated herein by reference. 
    
    
     BACKGROUND OF THE INVENTION 
     Sumatriptan, which has the structure below, is a drug used in the treatment of migraine. 
     
       
         
         
             
             
         
       
     
     Sumatriptan is available in the form of tablets for oral administration, solution for injection and solution for nasal spray. 
     SUMMARY OF THE INVENTION 
     The invention provides stable, spray-dried, particle formulations containing a triptan, such as sumatriptan, or a pharmaceutically acceptable salt of thereof, which are useful for pulmonary administration to the respiratory tract for treating migraine. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     In one embodiment, the invention is a stable, pharmaceutical composition of a triptan or a pharmaceutically acceptable salt thereof formulated for pulmonary delivery comprising spray-dried particles (also referred to herein as “powders” or “dry powders”) comprising the triptan or pharmaceutically acceptable salt thereof, wherein the triptan or salt thereof is present in the particles in amorphous form, crystalline form, or in a combination of both amorphous and crystalline forms. 
     Examples of triptans which can be formulated according to the invention included sumatriptan, zolmitriptan, rizatriptan, naratriptan, eletriptan, almortriptan, frovatriptan and avitriptan. In one embodiment, the triptan is not zolmitriptan. In preferred embodiments, the triptan is sumatriptan. A preferred sumatriptan salt is sumatriptan succinate. 
     In one embodiment, the invention is a pharmaceutical composition of a triptan, or a pharmaceutically acceptable salt thereof for pulmonary delivery comprising spray-dried particles containing the triptan or a pharmaceutically acceptable salt thereof and having a tap density of less than about 0.2 g/cm 3 . In one aspect of the invention, the tap density is from about 0.02 to 0.20 g/cm 3 . In another aspect of the invention, the tap density is from about 0.02 to 0.175 g/cm 3 . In a further aspect of the invention, the tap density is from about 0.03 to 0.175 g/cm 3 . In a further aspect of the invention, the tap density is from about 0.06 to 0.175 g/cm 3 . In one aspect of the invention, the tap density is from about 0.03 to 0.15 g/cm 3 . In another aspect of the invention the volume mean geometric diameter is about 3 μm to 20 μm, 5 μm to 20 μm, 5 μm to 10 μm, 7 μm to 15 μm, or 7 μm to 10 μm. 
     In one embodiment, the invention is a pharmaceutical composition for pulmonary delivery comprising particles containing a triptan or a pharmaceutically acceptable salt thereof and having a volume mean geometric diameter of greater than about 5 microns (μm) and a tap density of less than about 0.20 g/cm 3 . 
     In another embodiment, the invention is a method of delivering a triptan to the pulmonary system of a patient comprising the steps of: 
     providing a spray-dried particle formulation of the triptan or a pharmaceutically acceptable salt thereof in a compartment and an inhaler to a patient wherein said powder comprises particles of the triptan or a pharmaceutically acceptable salt thereof; dispersing the powder by breath actuation of the patient; and delivering the particles to the patient&#39;s respiratory system. 
     In one aspect of this invention, an inhaler is a dry powder inhaler. A variety of inhalers can be used including the Aerolizer, Diskus, Flexhaler, Handihaler, Neohaler, Pressair, Rotahaler, Turbohaler, and Twisthaler. Other dry powder inhalers which can be used are described in U.S. Pat. Nos. 6,766,799, 7,278,425 and 8,496,002 each of which are hereby incorporated in by reference for their disclosure relating to the inhalation devices described therein. In one aspect of the invention, the compartment is a capsule or a blister pack. In one aspect of the invention, the inhaler has a resistance of about 0.05 to about 0.25, about 0.15 to about 0.25, 0.05 to about 0.15, 0.2 to about 0.25, or about 0.2. Resistance as referred herein is measured in: Square root of Cm H2O /Liters per minute. 
     In another aspect of the invention, the triptan powder in said compartment has a volume median geometric diameter of greater than about 3 μm, of about 3 μm to about 30 μm, of about 3 μm to about 20 μm, of about 5 μm to about 20 μm, of about 5 μm to about 15 μm, of about 5 μm to about 10 μm, or of about 7 μm to about 10 μm. In one specific embodiment, the particles in said compartment have a volume median geometric diameter of 6-10 μm and the particles delivered to the patient&#39;s respiratory tract have a volume median geometric diameter of 8-9 μm. In another embodiment, the particles delivered to the patient&#39;s respiratory tract have a volume median geometric diameter of 6-8 μm. In another embodiment, the particles delivered to the patient&#39;s respiratory tract have a 5 to 20% smaller, 5 to 10% smaller, or 8 to 15% smaller volume median geometric diameter than the particles in said compartment. 
     In one embodiment, the invention is a pharmaceutical composition for pulmonary delivery comprising particles comprising a triptan or a pharmaceutically acceptable salt thereof having a volume median geometric diameter of greater than about 5 μm and a tap density of less than about 0.20 g/cm 3 . 
     In one embodiment, the particles comprise the triptan or a pharmaceutically acceptable salt thereof, a phospholipid and a salt. In another aspect of this invention, the particles comprise the triptan or a pharmaceutically acceptable salt thereof, a phospholipid, a salt, an optional amino acid, and an optional sugar and/or sugar alcohol. 
     Examples of salts suitable for use in the compositions of the invention include, but are not limited to sodium chloride (NaCl), sodium citrate, sodium lactate, and potassium chloride. Examples of phospholipids suitable for use in the compositions of the invention include, but are not limited to, dipalmitoylphosphatidylcholine (DPPC) dilauroylphosphatidylcholine (DLPC), disaturated-phosphatidylcholine (DSPC). In one embodiment, the sodium chloride is present in 1%, 2%, or 3% by weight. Examples of amino acids suitable for use in the compositions of the invention include, but are not limited to, hydrophobic amino acids such as leucine, isoleucine, alanine, valine, phenylalanine and glycine. In one embodiment, the chiral amino acid is an L-amino acid, and the term leucine as used herein refers to L-leucine unless otherwise indicated. Examples of sugars and sugar alcohols suitable for use in the compositions of the invention include, but are not limited to, lactose, trehalose, mannitol, maltodextrin and polyglycitol. The maltodextrin can have a dextrose equivalence (DE) of 3 to 20%. In certain embodiments, the maltodextrin has a DE of 4-7%, 10-12% or 16-19%. In one embodiment, the maltodextrin has a DE of 10.7%. In certain embodiments, the polyglycitol is SD-30 or SD-60. 
     In one embodiment, the particles comprise sumatriptan or a pharmaceutically acceptable salt thereof, DPPC, sodium chloride and maltodextrin. 
     In one embodiment, the particles comprise sumatriptan or a pharmaceutically acceptable salt thereof, DPPC, sodium chloride and 1-leucine. 
     In one embodiment, the pharmaceutical composition contains a powder comprising 5 to 50% triptan or a pharmaceutically acceptable salt thereof, 5-20% phospholipid, and 1-10% sodium chloride as measured by percent of dry solids in the powder. In preferred embodiments, the pharmaceutical composition contains a powder comprising 25 to 55% or 30 to 50% triptan or a pharmaceutically acceptable salt thereof, 5-20% phospholipid, 1-10% sodium chloride and 25 to 60% or 30 to 50% of an excipient selected from maltodextrins, lactose, glycine, trehalose, mannitol and 1-leucine, as measured by percent of dry solids in the powder. In one embodiment, the tritan is sumatriptan free base. In another embodiment the triptan is a sumatriptan salt, such as sumatriptan succinate salt. 
     In one embodiment, the pharmaceutical composition contains a powder comprising 25 to 55% or 30 to 50% triptan or a pharmaceutically acceptable salt thereof, preferably sumatriptan free base, 15-20% phospholipid, 1-5% sodium chloride and 25 to 55% or 30 to 50% of an excipient selected from maltodextrins, and 1-leucine, as measured by percent of dry solids in the powder. In a preferred embodiment, the powder comprises 30 to 50% triptan or a pharmaceutically acceptable salt thereof, preferably sumatriptan free base, about 18% phospholipid, such as DPPC, about 2% sodium chloride and 30 to 50% of an excipient selected from maltodextrins, such as polyglycitol (for example, SD-30 or SD-60) or maltodextrin (DE=10.7%), as measured by percent of dry solids in the powder. 
     In one embodiment the triptan is sumatriptan (free base or succinate salt) and the pharmaceutical composition has a formulation shown in Table 1 or Table 2, where the amount of each component is provided as weight %. 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                 Sumatriptan 
                   
                 Sodium 
                   
                 Sugar/Sugar 
               
               
                 Succinate 
                 DPPC 
                 Chloride 
                 Amino Acid 
                 alcohol 
               
               
                   
               
             
            
               
                 25% 
                 18% 
                 2% 
                 55% (leucine) 
                 0 
               
               
                 50% 
                 18% 
                 2% 
                 30% (leucine) 
                 0 
               
               
                 50% 
                 18% 
                 2% 
                 0 
                 30% (maltodextrin; 
               
               
                   
                   
                   
                   
                 DE = 4.0-7.0%, 
               
               
                   
                   
                   
                   
                 10.7%, 16.0-19.0%) 
               
               
                 50% 
                 18% 
                 2% 
                 0 
                 30% (lactose) 
               
               
                 50% 
                 18% 
                 2% 
                 0 
                 30% (mannitol) 
               
               
                 50% 
                 18% 
                 2% 
                 0 
                 30% (trehalose) 
               
               
                 25% 
                 18% 
                 2% 
                 0 
                 55% (trehalose) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 2 
               
               
                   
               
               
                 Sumatriptan 
                   
                 Sodium 
                   
                 Sugar/Sugar 
               
               
                 Free base 
                 DPPC 
                 Chloride 
                 Amino Acid 
                 alcohol 
               
               
                   
               
             
            
               
                 50% 
                 18% 
                 2% 
                 30% (leucine) 
                 0 
               
               
                 50% 
                 18% 
                 2% 
                 0 
                 30% (maltodextrin; 
               
               
                   
                   
                   
                   
                 DE = 4.0-7.0%, 
               
               
                   
                   
                   
                   
                 10.7%, 16.0-19.0%) 
               
               
                 50% 
                 18% 
                 2% 
                 0 
                 30% (lactose) 
               
               
                 50% 
                 18% 
                 2% 
                 30% (glycine) 
                 0 
               
               
                   
               
            
           
         
       
     
     In one embodiment, particles of this invention have an external surface area of greater than 10 m 2 /g. In another embodiment, the external surface area is greater than 15 m 2 /g, greater than 20 m 2 /g or about 10 to about 50 m 2 /g. 
     Gravimetric analysis, using Cascade impactors, is a method of measuring the size distribution of airborne particles. The Andersen Cascade Impactor (ACI) is an eight-stage impactor that can separate aerosols into nine distinct fractions based on aerodynamic size. The size cutoffs of each stage are dependent upon the flow rate at which the ACI is operated. Preferably the ACI is calibrated at 60 L/min. In one embodiment, a two-stage collapsed ACI is used for particle optimization. The two-stage collapsed ACI consists of stages 0, 2 and F of the eight-stage ACI and allows for the collection of two separate powder fractions. At each stage an aerosol stream passes through the nozzles and impinges upon the surface. Particles in the aerosol stream with a large enough inertia will impact upon the plate. Smaller particles that do not have enough inertia to impact on the plate will remain in the aerosol stream and be carried to the next stage. 
     The ACI is calibrated so that the fraction of powder that is collected on a first stage is referred to herein as “fine particle fraction” or “FPF”. The FPF corresponds to the percentage of particles that have an aerodynamic diameter of less than 5.6 μm. The fraction of powder that passed the first stage of the ACI and is deposited on the collection filter is referred to as “FPF(3.4)”. This corresponds to the percentage of particles having an aerodynamic diameter of less than 3.4 μm. 
     The FPF fraction has been demonstrated to correlate to the fraction of the powder that is deposited in the lungs of the patient, while the FPF(3.4) has been demonstrated to correlate to the fraction of the powder that reaches the deep lung of a patient. 
     In accordance with the invention, the FPF of the inhalable powder of the nominal dose contained in the capsule (i.e., the percentage of particles in the powder contained in the capsule that have an aerodynamic diameter of less than 5.6 μm) is about 20%, 30%, 40% or more. In one embodiment the FPF of the nominal dose of the inhalable powder contained in the capsule is about 50%, 60%, or 70%. In one embodiment the FPF is about 30% to about 90% of the nominal dose of the inhalable powder contained in the inhaler. In one embodiment the FPF is about 50% to about 60% of the nominal dose of the inhalable powder contained in the inhaler. In one embodiment the FPF is about 40% to about 60% of the nominal dose of the inhalable powder contained in the inhaler. In one embodiment the FPF is about 50% to about 56% of the nominal dose of the inhalable powder contained in the inhaler. In one embodiment the FPF is about 30% to about 60% of the nominal dose of the inhalable powder contained in the inhaler. In one embodiment the FPF is about 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60% of the nominal dose of the inhalable powder contained in the inhaler. 
     In accordance with the invention, the FPF(3.4) of the inhalable powder of the nominal dose contained in the capsule (i.e., the percentage of particles in the powder contained in the capsule that have an aerodynamic diameter of less than 3.4 μm) is about 30%, 40%, 50% or more. In one embodiment the FPF(3.4) of the nominal dose of the inhalable powder contained in the capsule is about 30% or more. In one embodiment the FPF(3.4) is at least about 40% or 50% of the nominal dose of the inhalable powder contained in the inhaler. In one embodiment the FPF(3.4) is about 30% to 60% of the nominal dose of the inhalable powder contained in the inhaler. In one embodiment the FPF(3.4) is about 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60% of the nominal dose of the inhalable powder contained in the inhaler. 
     As used herein, the term “nominal powder dose” is the total amount of powder held in the capsule. As used herein, the term “nominal drug dose” is the total amount of triptan or triptan salt contained in the nominal powder dose. The nominal powder dose is related to the nominal drug dose by the load percent of drug in the powder. 
     In one embodiment, the nominal powder dose is 25-50 mg by dry weight. In a further embodiment, the nominal powder dose is 25-40 mg by dry weight. In a still further embodiment, the nominal powder dose is 30-35 mg by dry weight or 32-38 mg by dry weight. 
     Another method for measuring the size distribution of airborne particles is the Multi-stage liquid Impinger (MSLI). The Multi-stage liquid Impinger (MSLI) operates on the same principles as the Anderson Cascade Impactor (ACI), but instead of eight stages there are five in the MSLI. Additionally, instead of each stage consisting of a solid plate, each MSLI stage consists of a methanol-wetted glass frit. The wetted stage is used to prevent bouncing and re-entrainment, which can occur using the ACI. The MSLI is used to provide an indication of the flow rate dependence of the powder. This can be accomplished by operating the MSLI at 30, 60, and 90 L/min and measuring the fraction of the powder collected on stage 1 and the collection filter. If the fractions on each stage remain relatively constant across the different flow rates, then the powder is considered to be approaching flow rate independence. 
     In one embodiment, the inhalable powders of the invention have a tap density of less than about 0.075 g/cm 3 . For example, the particles have a tap density between 0.02 and 0.20 g/cm 3 , between 0.02 and 0.15 g/cm 3 , between 0.03 and 0.12 g/cm 3 , between 0.05 and 0.15 g/cm 3 , or less than about 0.15 g/cm 3 , or a tap density less than about 0.10 g/cm 3 , or a tap density less than about 0.15 g/cm 3 , or between 0.06 to 0.15 g/cm 3 . Tap density can be measured by using instruments known to those skilled in the art such as the Dual Platform Microprocessor Controlled Tap Density Tester (Vankel, N.C.) or a GEOPYC™ instrument (Micrometrics Instrument Corp., Norcross, Ga., 30093). Tap density is a standard measure of the envelope mass density. Tap density can be determined using the method of USP Bulk Density and Tapped Density, United States Pharmacopeia convention, Rockville, Md., 10 th  Supplement, 4950-4951, 1999. Features which can contribute to low tap density include irregular surface texture and porous structure. The envelope mass density of an isotropic particle is defined as the mass of the particle divided by the minimum sphere envelope volume within which it can be enclosed. In one embodiment of the invention, the particles have an envelope mass density of less than about 0.4 g/cm 3 . 
     The inhalable powder of the invention has a preferred particle size, e.g., a volume mean geometric diameter (VMGD) of at least about 1 micron (μm). In embodiments, the VMGD is greater than 3 μm or greater than 5 μm. In other embodiments, the VMGD is between about 5 μm and 20 μm, between about 5 μm and 10 μm, between about 6 μm and 15 μm and between about 7 μm and 12 μm. In another aspect of the invention, the powder particles have a VMGD of about 2 μm to 15 μm, 3 μm to 12 μm, 3 μm to 8 μm, 5 μm to 9 μm, or 6 μm to 9 μm. The diameter of the spray-dried particles, for example, the VMGD, can be measured using a laser diffraction instrument (for example Helos, manufactured by Sympatec, Princeton, N.J.). Other instruments for measuring particle diameter are well known in the art. The diameter of particles in a sample will range depending upon factors such as particle composition and methods of synthesis. The distribution of size of particles in a sample can be selected to permit optimal deposition to targeted sites within the respiratory tract. 
     The particles of the inhalable powder of the invention preferably have a “mass median aerodynamic diameter” (MMAD), also referred to herein as “aerodynamic diameter”, between about 1 μm and about 5 μm or any subrange encompassed between about 1 μm and about 5 μm. For example, but not limited to, the MMAD is between about 1 μm and about 3 μm, or the MMAD is between about 3 μm and about 5 μm. In one embodiment, the MMAD is between 1.5 μm and 2.5 μm. Experimentally, aerodynamic diameter can be determined by employing a gravitational settling method, whereby the time for an ensemble of powder particles to settle a certain distance is used to infer directly the aerodynamic diameter of the particles. An indirect method for measuring the mass median aerodynamic diameter (MMAD) is the multi-stage liquid impinger (MSLI). The aerodynamic diameter, d aer , can be calculated from the equation: 
       d aer =d g √ρ tap  
 
     where d g  is the geometric diameter, for example the MMGD, and ρ is the powder density. 
     Powders for use in capsules of this invention are typically produced by spray drying. In some cases, spray-drying can produce extremely dry particles which may have poor handling properties and may be difficult to compact into a capsule in a dense manner. A nitrogen source with a specified moisture level may be blown over, across, or through the dry powder to add a specific moisture content to the dry powder. Such moisture can provide the desired working density of the powder. Moisture content can be about 1-10% by weight, about 1-5% by weight, or 2-3% by weight. Spray drying methods in accordance with the invention are described in the Examples herein and in U.S. Pat. Nos. 6,848,197 and 8,197,845, incorporated herein by reference. 
     In certain embodiments, the triptan particles of the invention are prepared by the following process. DPPC, and the triptan salt or free base are allowed to equilibrate to room temperature before weighing. Required amounts of water and ethanol are transferred to the aqueous and organic phase feed vessels respectively, and then stirred. In embodiments in which the triptan is sumatriptan in the form of the succinate salt, the required amounts of sodium chloride, the excipient of choice (for example, L-leucine, glycine, maltodextrin, mannitol, or trehalose) and sumatriptan succinate are dissolved in the aqueous phase vessel. The required amount of DPPC is dissolved in the organic phase vessel. 
     In embodiments in which the triptan is sumatriptan free base, the required amounts of sodium chloride and the excipient of choice (for example, L-leucine, glycine, maltodextrin, mannitol, or trehalose) are dissolved in the aqueous phase vessel. The required amount of sumatriptan free base and DPPC are dissolved in the organic phase vessel. 
     Spray drying is initiated by starting the drying gas flow and heating up the drying gas by setting the desired inlet temperature. After the spray dryer outlet temperature reaches a suitable temperature, for example 55° C., the liquid skid inlet is set to allow blank solvents to be atomized with the aid of nitrogen into the spray dryer, and the system is allowed to cool and stabilize, for example, at a temperature of 40 to 50° C., preferably 44° C. Product filter pulsing is initiated and product filter purge flow is set to 10 to 20 scfh, preferably about 15 scfh. After the system stabilizes, the liquid skid inlet is switched to the feed solvents prepared above and the process is continued till the feed solvents run out. At the point when feed solvents run out, the liquid skid inlet is switched back to blank solvents which are allowed to spray for about 5 to 20 minutes. At this point, powder collected at the bottom of the product filter is transferred to its final collection vessel in a glove box maintained at a relative humidity of about 10 to 20%, preferably about 15%. After spraying the blank solvent for 5 to 20 minutes, preferably about 10 minutes, the system is shut down by shutting down the liquid lines, atomization gas, drying gas heater, drying gas inlet and finally the exhaust. 
     The inhalable powder comprising a triptan as described above is used to fill capsules suitable for use in an inhaler. The term “capsule material” as used herein refers to the material from which the shell of the capsule for inhalation is made. In one embodiment, the capsule material according to the invention is selected from among gelatin, cellulose derivatives, starch, starch derivatives, chitosan and synthetic plastics. 
     If gelatin is used as the capsule material, examples according to the invention may be selected from among polyethyleneglycol (PEG), PEG 3350, glycerol, sorbitol, propyleneglycol, PEO-PPO block copolymers and other polyalcohols and polyethers. If cellulose derivatives are used as the capsule material, examples according to the invention may be selected from hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose, methylcellulose, hydroxymethylcellulose and hydroxyethylcellulose. If synthetic plastics are used as the capsule material, examples according to the invention may be selected from polyethylene, polycarbonate, polyester, polypropylene and polyethylene terephthalate. In one embodiment, the capsule material further comprises titanium dioxide. In one preferred embodiment the capsule comprises HPMC and titanium dioxide. In one embodiment, the capsule comprises carrageenan. In a further embodiment, the capsule comprises potassium chloride. In a still further embodiment, the capsule comprises, HPMC, carrageenan, potassium chloride, and titanium dioxide. In one embodiment, the capsule size is selected from 000, 00, 0, 1, or 2. In a specific embodiment, the capsule size is 00. In another specific embodiment, the capsule size is 2. 
     In one specific embodiment, the capsule is a hydroxypropylmethylcellulose (HPMC) capsule. In another specific embodiment, the capsule is a hydroxypropylmethylcellulose size 00 capsule. In one specific embodiment the capsule material comprises HPMC and titanium dioxide and the capsule size is 00. 
     In one embodiment, a 00 capsule contains between 15 and 50 mg of sumatriptan by dry weight. In another embodiment, a 00 capsule contains between 20 and 40 mg of sumatriptan by dry weight. In another embodiment, a 00 capsule contains between 25 and 35 mg of sumatriptan by dry weight. In another embodiment, a 00 capsule contains about 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 mg of sumatriptan by dry weight. 
     In one aspect of the invention, the powders have low electrostatic charge to enable high dispersion from the capsule. 
     The capsules of the invention are particularly suitable for use in a dry powder inhaler for the delivery of a dry powder composition comprising an effective amount of a triptan, preferably sumatriptan or salt thereof, to a subject in need thereof, for example, for treating migraine or duster headache. 
     In one embodiment, the invention provides a method for treating migraine in a subject in need thereof, preferably a human patient, comprising the step of administering to the subject a therapeutically effective amount of a triptan composition of the invention. The composition is preferably administered to the subject&#39;s pulmonary system, for example, using an inhaler, such as a dry powder inhaler, as described herein. The triptan compositions of the invention are useful for the acute treatment of migraine, providing relief of one or more symptoms of migraine, for example, pain, nausea, photophobia or phonophobia, and/or shortening the duration of migraine. In certain embodiments, administration of a triptan composition of the invention provides relief of pain. In certain embodiments, administration of a triptan composition of the invention provides relief of pain and at least one of nausea, photophobia and phonophobia. In certain embodiments, administration of a triptan composition of the invention provides relief of at least pain and nausea. In certain embodiments, administration of a triptan composition of the invention provides relief of each of pain, nausea, photophobia and phonophobia. The migraine to be treated can be migraine with or without aura. In preferred embodiments, administration of the triptan formulation of the invention provides relief of pain within about 15 minutes or within about 30 minutes of administration. 
     In another embodiment, the invention provides a method for treating cluster headache in a subject in need thereof, preferably a human patient, comprising the step of administering to the subject a therapeutically effective amount of a triptan composition of the invention. The triptan compositions of the invention are useful for acute treatment of cluster headache, that is, providing relief from one or more symptoms of cluster headache and/or shortening the duration of cluster headache. 
     The composition of the invention is preferably administered to the subject&#39;s pulmonary system, for example, using an inhaler, such as a dry powder inhaler, as described herein. 
     In one embodiment, the subject to be treated is an adult human. In another embodiment, the subject to be treated is a pediatric human, for example a human from about 6 to about 11 years of age, about 12 to about 17 years of age, or about 6 to about 17 years of age. In another embodiment, the subject is a human infant, for example, up to two years of age, a human of about 6 years of age or less. 
     As used herein, the term “therapeutically effective amount” means the amount needed to achieve the desired effect or efficacy. A therapeutically effective amount of a triptan composition for treating migraine or cluster headache is an amount of the triptan composition which provides relief from migraine or cluster headache or one or more symptoms of migraine or cluster headache. Such an amount of the triptan composition thereof preferably shortens the duration and/or intensity of a migraine or cluster headache or one or more symptoms thereof, such as pain and/or aura. The actual effective amount of drug can vary according to the specific drug or combination thereof being utilized, the particular composition formulated, the mode of administration, and the age, weight, condition of the patient, and severity of the episode being treated. 
     In certain embodiments, the triptan formulation is administered to the subject two or more times for a single migraine episode or cluster headache. For example, a first dose can be administered to the subject, followed by a second or more doses at appropriate time intervals, such as about 1 or 2 hour intervals. 
     The present invention will be further understood by reference to the following non-limiting examples. 
     EXAMPLES 
     Example 1 
     Example 1: Evaluation of Different Excipients 
     Four excipients were compared as a part of this evaluation—L-leucine, Maltodextrin (DE=10.7%), Lactose, and Mannitol. Tables 3, 4, 5, and 6 provide a summary of the aerosol properties for L-leucine, Maltodextrins (DE=10.7%), Lactose, and Mannitol based formulations respectively. Table 7 summarizes the solid state properties of one L-leucine based and one Maltodextrin based formulation. Process parameters used for all these evaluations are summarized in Tables 29, 30, 31, and 32 respectively. 
     L-Leucine 
     Reagent grade L-leucine (Sigma Aldrich) was evaluated as a part of this study. Two Sumatriptan succinate loads (25% and 50%), three total solid concentrations of the spray drying solution (2 g/L, 4 g/L, and 6 g/L), and four solvent flow ratios (8:32 v:v Aqueous:Organic, 16:24 v:v Aqueous:Organic, 24:16 v:v Aqueous:Organic, and 32:8 v:v Aqueous:Organic) are evaluated with L-leucine. Process parameters used for this evaluation are detailed in Table 27. Table 1 below details the aerosol results obtained from this evaluation. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Aerosol properties summary for L-leu based Sumatriptan succinate formulations 
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 Lot Number 
                 117077 
                 117078 
                 117079 
                 117080 
                 117081 
                 117082 
                 117083 
                 117084 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 Total solid 
                 2 
                 4 
                 6 
                 4 
                 2 
                 4 
                 6 
                 4 
               
               
                 concentration (g/L) 
                   
                   
                   
                   
                   
                   
                   
                   
               
            
           
           
               
               
               
            
               
                 Sumatriptan succinate (%) 
                 25 
                 50 
               
               
                 L-leucine (%) 
                 55 
                 30 
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 Aqueous Flow (mL/min) 
                 8 
                 16 
                 24 
                 32 
                 8 
                 16 
                 24 
                 32 
               
               
                 Organic flow (mL/min) 
                 32 
                 24 
                 16 
                 8 
                 32 
                 24 
                 16 
                 8 
               
               
                 Fine particle fraction, 
                 56 
                 49 
                 39 
                 35 
                 39 
                 38 
                 26 
                 21 
               
               
                 &lt;5.6 um (%) (Size 00) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Water content (%) 
                 1.69 
                 2.18 
                 2.03 
                 1.75 
                 1.87 
                 2.68 
                 1.52 
                 1.39 
               
               
                 gPSD (VMGD 1 bar, mm) 
                 3.8 
                 10.6 
                 15.2 
                 11.1 
                 7.1 
                 9.5 
                 11.5 
                 15.6 
               
               
                 Bulk/Aerated Density (g/cc) 
                 0.063 
                 0.041 
                 0.049 
                 0.078 
                 0.066 
                 0.059 
                 0.081 
                 0.096 
               
               
                 Tap Density (g/cc) 
                 0.091 
                 0.063 
                 0.067 
                 0.129 
                 0.116 
                 0.079 
                 0.105 
                 0.121 
               
               
                   
               
            
           
         
       
     
     Formulations with the higher aqueous ratio are observed to produce particles with a lower FPF value and a higher gPSD, for both 25% and 50% Sumatriptan succinate formulations. Formulations with the higher aqueous ratios are also observed to produce more dense powder particles. In this and subsequent tables the amounts of Sumatriptan succinate and excipients are presented as fractions by weight of total solids. 
     Table 2 below details the solid state results obtained for the powder containing 50% Sumatriptan succinate and 30% L-leucine, spray dried at an Aqueous:Organic ratio of 24:16 v:v. and at a total solid concentration of 6 g/L. 
     
       
         
           
               
             
               
                 TABLE 2 
               
               
                   
               
               
                 Summary of Solid state properties for 
               
               
                 50% Sumatriptan succinate formulation 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Lot Number 
                 117083 
               
               
                   
                 Total solid concentration (g/L) 
                 6 
               
               
                   
                 Sumatriptan succinate (%) 
                 50 
               
               
                   
                 L-leucine 
                 30 
               
               
                   
                 XRPD 
                 PC-T1 
               
               
                   
                 TGA-120 (%) 
                 NT 
               
               
                   
                 Low T Endotherm 1/Tg (° C.) 
                 52.6 
               
               
                   
                 Low T Endotherm 2/Tg (° C.) 
                 59.7 
               
               
                   
                 Recrystallization Exotherm (° C.) 
                 Broad 
               
               
                   
                 High T Melt Endotherm 
                 Broad 
               
               
                   
                   
               
            
           
         
       
     
     Maltodextrins 
     Maltodextrin having a dextrose equivalent of 10.7% (Sigma Aldrich) is evaluated as a part of this study. Three total solid concentrations of the spray drying solution (2 g/L, 4 g/L, and 6 g/L), and two solvent flow ratios (16:24 v:v Aqueous:Organic, and 24:16 v:v Aqueous:Organic) are evaluated with Maltodextrins (DE=10.7%). The Sumatriptan load is kept constant at 50%. Process parameters used for this evaluation are detailed in Table 28. Table 3 below details the results obtained from this evaluation. 
                     TABLE 3                  Aerosol properties summary for Maltodextrins       based Sumatriptan succinate formulations                                 Lot Number   117091   117092   117093   117094                                         Total solid concentration (g/L)   2   4   2   4                     Sumatriptan succinate (%)   50       Maltodextrins (DE = 10.7%) (%)   30                                 Aqueous Flow (mL/min)   16   16   24   24       Organic flow (mL/min)   24   24   16   16       Fine particle fraction, &lt;5.6 um (%)   34   35   28   27       (Size 00)       Water content (%)   NT   NT   NT   NT       gPSD (VMGD 1 bar, mm)   12.6   9.9   7.3   6.8       Bulk/Aerated Density (g/cc)   0.019   0.034   0.104   0.119       Tap Density (g/cc)   0.022   0.043   0.114   0.128                    
For both solvent ratios with Maltodextrin (DE=10.7%), the gPSD and FPF are observed to decrease and the density is observed to increase as the total solid concentration increases from 2 g/L to 4 g/L Table 4 below summarizes the solid state properties of the formulation spray dried at an Aqueous:Organic ratio of 16:26 v:v at 2 g/L total solid concentration.
 
     
       
         
           
               
             
               
                 TABLE 4 
               
               
                   
               
               
                 Solid state properties of Lot 117091 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Lot Number 
                 117091 
               
               
                   
                 Total solid concentration (g/L) 
                 2 
               
               
                   
                 Sumatriptan succinate (%) 
                 50 
               
               
                   
                 Maltodextrins (%) 
                 30 
               
               
                   
                 XRPD 
                 A-T2 
               
               
                   
                 TGA-120 (%) 
                 NT 
               
               
                   
                 Low T Endotherm 1/Tg (° C.) 
                 42 
               
               
                   
                 Low T Endotherm 2/Tg (° C.) 
                 49.3 
               
               
                   
                 Recrystallization Exotherm (° C.) 
                 None 
               
               
                   
                 High T Melt Endotherm 
                 None 
               
               
                   
                   
               
            
           
         
       
     
     Lactose 
     Inhalation grade lactose (DFE Pharma) was evaluated as a part of this study. Two total solid concentrations of the spray drying solution (2 g/L and 4 g/L), and two solvent flow ratios (16:24 v:v Aqueous:Organic and 24:16 Aqueous:Organic) were evaluated with Lactose. Process parameters used for this evaluation are detailed in Table 29. Table 5 below details the results obtained from this evaluation. 
                     TABLE 5                  Aerosol properties summary for Lactose based       Sumatriptan succinate formulations                                 Lot Number   117103   117104   117105   117106                                         Total solid concentration (g/L)   2   4   2   4                     Sumatriptan succinate (%)   50       Lactose (%)   30                                 Aqueous Flow (mL/min)   16   16   24   24       Organic flow (mL/min)   24   24   16   16       Fine particle fraction, &lt;5.6 um (%)   23   28   22   21       (Size 00)       Water content (%)   2.36   2.31   3.89   4.22       gPSD (VMGD 1 bar, mm)   7.1   6.5   8.2   8.8       Bulk/Aerated Density (g/cc)   0.150   0.100   0.141   0.144       Tap Density (g/cc)   0.181   0.129   0.17   0.186                    
For both solvent ratios with Lactose, the gPSD, water content, and FPF are observed is observed to stay constant with varied total solid concentration and a constant Aqueous:Organic ratio.
 
     Mannitol 
     USP grade Mannitol (BDH) was evaluated as a part of this study. Two total solid concentrations of the spray drying solution (2 g/L and 4 g/L), and two solvent flow ratios (16:24 v:v Aqueous:Organic and 24:16 Aqueous:Organic) were evaluated with Lactose. Process parameters used for this evaluation are detailed in Table 29. Table 6 below details the results obtained from this evaluation. 
                     TABLE 6                  Aerosol properties summary for Mannitol       based Sumatriptan succinate formulations                                 Lot Number   117107   117108   117109   117110                                         Total solid concentration (g/L)   2   4   2   4                     Sumatriptan succinate (%)   50       Mannitol (%)   30                                 Aqueous Flow (mL/min)   16   16   24   24       Organic flow (mL/min)   24   24   16   16       Fine particle fraction, &lt;5.6 um (%)   31   27   NT   NT       (Size 00)       Water content (%)   2.59   3.23   NT   NT       gPSD (VMGD 1 bar, mm)   5.4   6.9   44.7   NT       Bulk/Aerated Density (g/cc)   0.098   0.104   0.139   NT       Tap Density (g/cc)   0.147   0.126   0.156   NT                    
For the Mannitol based formulations, not enough powder was produced for the 24:16 Aqueous:Organic flow formulations. For the 16:24 Aqueous:Organic flow formulations, the FPF was observed to decrease and the gPSD, water content, and density were observed to increase as the total solid concentration increased from 2 g/L to 4 g/L.
 
     Example 2: Increased Atomization Gas 
     This evaluation was performed to evaluate the effect of increased atomization gas on the gPSD and FPF of the resultant powder. For the purpose of this evaluation, a 50:30:18:2 Sumatriptan succinate:Maltodextrin:DPPC:NaCl formulation was spray dried using the process parameters described in Table 33. The Aqueous:Organic ratio was maintained at 20:80 v:v and the spray dryer outlet temperature was maintained at 44° C. Table 7 summarizes the aerosol data from this evaluation. 
                     TABLE 7                  Effect of increase in atomization gas flow on the properties       of Maltodextrin based Sumatriptan succinate formulations                             Lot Number   117153-1   117153-2   117153-3                                     Total solid concentration (g/L)   4   4   4       Atomization gas flow rate   22   33   44       Fine particle fraction, &lt;5.6 um (%)   48   62   56       (Size 00)       Water content (%)   3.8   3.91   3.72       gPSD (VMGD 1 bar, mm)   7.4   7.3   6.3       Bulk/Aerated Density (g/cc)   0.052   0.042   0.058       Tap Density (g/cc)   0.083   0.066   0.075                    
As expected, increasing the atomization gas flow rate is observed to slightly increase the FPF and decrease the gPSD of the powder formulation.
 
     Example 3: Formulations Produced Using Maltodextrins Having Varied D.E. Values 
     Sumatriptan succinate Maltodextrins with four different Dextrose equivalent (D.E.) values were compared as a part of this study. Two atomizing gas air cap configurations (67147—single hole air cap, and 67-6-20-150—six hole air cap, both from Spraying systems company) and two liquid flow ratios (16:24 Aqueous:Organic v:v, and 24:16 Aqueous:Organic v:v) were evaluated. The spray drying outlet temperature was maintained at 44° C. 
     Three of these evaluations were performed using Maltodextrins procured from Sigma Chemicals Limited (St. Louis, Mo.), and the fourth evaluation was conducted using Maltodextrins acquired from Ingredion (Westchester, Ill.) and from Grain Processing Corporation (Muscatine, Iowa). The spray drying outlet temperature was maintained at 44° C. for all four evaluations. 
     1. Six Hole Air Cap at 20:80 Aqueous:Organic Ratio (Sigma Maltodextrins) 
     Four Maltodextrins from Sigma Chemicals were evaluated—Maltodextrin (DE=4.0-7.0%), Maltodextrin (DE=10.7%), Maltodextrin (DE=13.0-16.5%), and Maltodextrin (DE=16.0-19.0%) with a single hole air cap (Model 67147, Spraying systems Co.) at a 20:80 v:v Aqueous:Organic ratio. 
     Table 8 summarizes the formulation components and aerosol data for the first comparison listed above and Table 34 lists the process parameters used for this comparison. 
                     TABLE 8                  Aerosol properties of Sumatriptan succinate formulations with       Maltodextrins from Sigma (20:80 Aq:Org ratio, 1-hole air cap)                                 Lot Number   117177   117178   117179   117180                                         Total solid concentration (g/L)   4   4   4   4       Sumatriptan succinate (%)   50   50   50   50       Maltodextrin (DE = 4.0-7.0%) (%)   30       Maltodextrin (DE = 10.7%) (%)       30       Maltodextrin (DE = 13.0-16.5%)           30       (%)       Maltodextrin (DE = 16.0-19.0%)               30       (%)       DPPC (%)   18   18   18   18       Sodium chloride (%)   2   2   2   2       Fine particle fraction, &lt;5.6 um (%)   48   51   53   44       (Size 00)       Water content (%)   5.74   4.5   4.82   5.49       gPSD (VMGD 1 bar, mm)   4.5   3.3   2.9   3.2       Bulk/Aerated Density (g/cc)   0.067   0.062   0.071   0.091       Tap Density (g/cc)   0.123   0.119   0.109   0.121                    
As seen in Table 8, all aerosol properties stay constant over the course of this evaluation. The only change seen is that the density of the powder is observed to increase as the dextrose equivalent value increases.
 
     2. Six Hole Air Cap at 40:60 Aq:Org Ratio (Sigma Maltodextrins) 
     Four Maltodextrins from Sigma Chemicals were evaluated—Maltodextrin (DE=4.0-7.0%), Maltodextrin (DE=10.7%), Maltodextrin (DE=13.0-16.5%), and Maltodextrin (DE=16.0-19.0%) with a six hole air cap (Model 67-6-20-150, Spraying systems Co.) 
     Table 9 summarizes the formulation components and aerosol data for the second comparison listed above and Table 35 lists the process parameters used for this comparison. 
                     TABLE 9                  Aerosol properties of Sumatriptan succinate formulations with       Maltodextrins from Sigma (20:80 Aq:Org ratio, 6-hole air cap)                                 Lot Number   117186   117188   117190   117191                                         Total solid concentration (g/L)   6   6   6   6       Sumatriptan succinate (%)   50   50   50   50       Maltodextrin (DE = 4.0-7.0%) (%)   30       Maltodextrin (DE = 10.7%) (%)       30       Maltodextrin (DE = 13.0-16.5%)           30       (%)       Maltodextrin (DE = 16.0-19.0%)               30       (%)       DPPC (%)   18   18   18   18       Sodium chloride (%)   2   2   2   2       Fine particle fraction, &lt;5.6 um (%)   34   36   34   40       (Size 00)       Water content (%)   4.76   5.02   5.11   4.44       gPSD (VMGD 1 bar, mm)   6.4   6.3   5.7   5.7       Bulk/Aerated Density (g/cc)   0.046   0.093   0.087   0.085       Tap Density (g/cc)   0.066   0.129   0.111   0.111                    
As seen in table 9 above, all four powders are observed to have lower FPF and densities, but slightly higher gPSDs as compared to the powders produced with a 20:80 ratio and the same nozzle during the first evaluation. However, these observations may also be due to a higher total solid concentration used in this evaluation.
 
     3. Single Hole Air Cap at 40:60 Aq:Org Ratio (Sigma Maltodextrins) 
     Four Maltodextrins from Sigma Chemicals were evaluated—Maltodextrin (DE=4.0-7.0%), Maltodextrin (DE=10.7%), Maltodextrin (DE=13.0-16.5%), and Maltodextrin (DE=16.0-19.0%) with a single hole air cap (Model 67147, Spraying systems Co.) at a 20:80 v:v Aqueous:Organic ratio. 
     Table 10 summarizes the formulation components and aerosol data for the third comparison listed above and Table 36 lists the process parameters used for this comparison. 
                     TABLE 10                  Aerosol properties of Sumatriptan succinate formulations with       Maltodextrins from Sigma (40:60 Aq:Org ratio, 1-hole air cap)                                 Lot Number   117164   117165   117166   117167                                         Total solid concentration (g/L)   6   6   6   6       Sumatriptan succinate (%)   50   50   50   50       Maltodextrin (DE = 4.0-7.0%) (%)   30       Maltodextrin (DE = 10.7%) (%)       30       Maltodextrin (DE = 13.0-16.5%)           30       (%)       Maltodextrin (DE = 16.0-19.0%)               30       (%)       DPPC (%)   18   18   18   18       Sodium chloride (%)   2   2   2   2       Fine particle fraction, &lt;5.6 um (%)   49   44   45   50       (Size 00)       Water content (%)   NT   NT   NT   NT       gPSD (VMGD 1 bar, mm)   3.9   4.2   4.1   4.4       Bulk/Aerated Density (g/cc)   0.097   0.135   0.124   0.135       Tap Density (g/cc)   0.152   0.147   0.143   0.157                    
As seen in Table 10 above, these powders seem to have a higher FPF and higher density but a lower gPSD as compared to the powders produced using a six hole nozzle at the same Aqueous:Organic ratio and total solid concentration.
 
     4. Six Hole Air Cap at 20:80 Aq:Org Ratio (GPC and Ingredion Maltodextrins) 
     Two Maltodextrins from Ingredion (Stabilite SD-30, and Stabilite SD-60) and five Maltodextrins from Grain Processing Corporation (Maltrin M-100, Maltrin M-150, Maltrin M-180, Maltrin M-200, and Maltrin M-250) were evaluated. Table 11 summarizes the formulation components and aerosol data for the third comparison listed above and Table 37 lists the process parameters used for this fourth comparison. 
                     TABLE 11                  Aerosol properties of Sumatriptan succinate formulations with Maltodextrins       from Ingredion &amp; GPC (20:80 Aq: Org ratio, 6-hole air cap)                                             Lot Number   155039   155040   155034   155035   155036   155037   155038                                                     Total solid   4   4   4   4   4   4   4       concentration (g/L)                                   Sumatriptan succinate (%)   50   50   50   50   50   50   50       Stabilite SD-30,   30                               Polyglycitol (%)                                   Stabilite SD-60,       30                           Polyglycitol (%)                                   Maltrin M-100,           30                       Maltodextrin (%)                                   Maltrin M-150,               30                   Maltodextrin (%)                                   Maltrin M-180,                   30               Maltodextrin (%)                                   Maltrin M-200,Corn                       30           syrup solids (%)                                   Maltrin M-250,Corn                           30       syrup solids (%)                                   DPPC (%)   18   18   18   18   18   18   18       Sodium chloride (%)   2   2   2   2   2   2   2       Fine particle fraction,   86   83   77   71   82   72   76       &lt;5.6 um (%) (Size 2)                                   Water content (%)   NT   NT   NT   NT   NT   NT   NT       gPSD (VMGD 1 bar, mm)   2.3   3   2.7   2.5   2.3   2.3   2.4       Bulk/Aerated Density (g/cc)   0.07   0.06   0.06   0.08   0.08   0.06   0.08       Tap Density (g/cc)   0.11   0.11   0.1   0.12   0.12   0.13   0.13                    
FPF measurement for these powders was done using a size 2 capsule as opposed to size 00 capsules for the earlier evaluation. Values for FPF, gPSD, and densities for all powders were observed to be similar.
 
     Example 4: Increased Spray Drying Outlet Temperature on L-Leu Based Formulation 
     Two spray drying outlet temperatures were evaluated−44° C. and 60° C. Additionally, Maltodextrins M-250 was compared to L-leucine at both spray dryer outlet temperatures. The Aqueous:Organic ratio used for all four powders was maintained at 20:80 v:v Process parameters for these evaluations are detailed in Table 38. Results for Fine particle fraction of these powders are listed in Table 12 below. 
                     TABLE 12                  FPF results for Sumatriptan succinate powders produced       at varied spray dryer outlet temperatures                                 Lot Number   155046   155047   155048   155049                                         Total solid concentration (g/L)   4   4   4   4       Outlet Temperature (° C.)   44   60   44   60       Sumatriptan succinate (%)   50   50   50   50       L-leucine (%)           30   30       Maltrin M-250, Corn syrup solids   30   30       (%)       DPPC (%)   18   18   18   18       Sodium chloride (%)   2   2   2   2       Fine particle fraction, &lt;5.6 um (%)   61   51   40   36       (Size 00)       Fine particle fraction, &lt;5.6 um (%)   80   66   53   46       (Size 2)                    
Powders produced at 44° C. were observed to have a higher FPF value as compared to powders produced at 60° C. Additionally, powders produced with Maltrin M-250 were observed to have a higher FPF as compared to the L-leucine powders.
 
     Example 5: Varied Sumatriptan Succinate Loads at 44° C. Spray Dryer Outlet Temperature 
     The effect of Sumatriptan succinate load on the aerosol and solid state properties of spray dried Sumatriptan succinate powder produced at an outlet temperature of 44° C. was evaluated for this study. Sumatriptan succinate load was varied from 40% to 70%, for which the L-leucine load was decreased from 40% to 10%. The DPPC ratio was maintained at 18%, and the Sodium chloride ratio was maintained at 2%. Aerosol data from these powders is summarized in Table 13 below. Process parameters used for this evaluation are detailed in Table 39. 
                     TABLE 13                  FPF results with increased Sumatriptan succinate       load at 44 C. spray dryer outlet temp                                 Lot Number   155004   155005   155006   155007                                         Total solid concentration (g/L)   4   4   4   4       Sumatriptan succinate (%)   40   50   60   70       L-leucine (%)   40   30   20   10                     DPPC (%)   18       Sodium chloride (%)   2                                 Fine particle fraction, &lt;5.6 um (%)   52   35   46   37       (Size 00)       Fine particle fraction, &lt;5.6 um (%)   54   49   45   32       (Size 2)       Water content (%)   NT   NT   3.33   2.98       gPSD (VMGD 1 bar, mm)   2.5   2.6   2.4   2.8       Bulk/Aerated Density (g/cc)   0.089   0.091   0.129   0.142       Tap Density (g/cc)   0.128   0.142   0.176   0.226                    
The FPF of the formulations is observed to decrease as the Sumatriptan succinate load increases. Both the particle size and the density values are observed to go up as the drug load goes up. In this and subsequent tables the FPF values presented are measured using only size 2 capsules.
 
     Example 6: Varied DPPC Loads at 44° C. Spray Dryer Outlet Temperature 
     The effect of DPPC load on the aerosol and solid state properties of spray dried Sumatriptan succinate powder produced at an outlet temperature of 44° C. was evaluated for this study. Four DPPC loads are evaluated—8%, 18%, 28%, and 38% and the Sumatriptan succinate load is kept constant. An increase in the DPPC load is balanced by decreasing the L-leucine load of the formulation. Table 40 details the process parameters used for this evaluation. Table 14 details the aerosol results for the four powders produced during this evaluation. 
                     TABLE 14                  FPF results with increased DPPC load       at 44 C. spray dryer outlet temp                                 Lot Number   155018   155019   155020   155021                                         Total solid concentration (g/L)   4   4   4   4                     Sumatriptan succinate (%)   50                                 L-leucine (%)   40   30   20   10       DPPC (%)   8   18   28   38                     Sodium chloride (%)   2                                 Fine particle fraction, &lt;5.6 um (%)   51   55   53   48       (Size 2)       gPSD (VMGD 1 bar, mm)   6.5   5.3   5   5.5       Bulk/Aerated Density (g/cc)   0.064   0.069   0.077   0.103       Tap Density (g/cc)   0.093   0.096   0.108   0.133                    
The FPF and gPSD are observed to stay constant as the DPPC load increases. However, the density values are observed to increase as the DPPC load increases.
 
     Example 7: Comparison of Different Maltodextrins (Spray Dryer Outlet Temperatures of 50 and 60° C.) 
     Two Maltodextrins from Ingredion (Stabilite SD-30, and Stabilite SD-60) and five Maltodextrins from Grain Processing Corporation (Maltrin M-100, Maltrin M-150, Maltrin M-180, Maltrin M-200, and Maltrin M-250) were evaluated during this study. 
     1. Spray Dryer Outlet Temperature of 50° C. 
     Four Maltodextrins were evaluated at 50° C.—SD-30, SD-60, M-200, and M-250. The Aqueous:Organic ratio was maintained at 20:80 v:v at a total liquid flow rate of 40 mL/min. Process parameters listed in Table 41 are used to produce this powder. Results from this evaluation are shown in Table 15 below. 
                     TABLE 15                  Aerosol results from Sumatriptan succinate       powders spray dried at 50 C.                                 Lot Number   155043   155044   155041   155042                                         Total solid concentration (g/L)   4   4   4   4       Sumatriptan succinate (%)   50   50   50   50       Stabilite SD-30, Polyglycitol (%)   30       Stabilite SD-60, Polyglycitol (%)       30       Maltrin M-200, Corn syrup solids           30       (%)       Maltrin M-250, Corn syrup solids               30       (%)       DPPC (%)   18   18   18   18       Sodium chloride (%)   2   2   2   2       Fine particle fraction, &lt;5.6 um (%)   76   78   80   76       (Size 2)       Water content (%)       gPSD (VMGD 1 bar, mm)   2.1   2.3   2.3   2.6       Bulk/Aerated Density (g/cc)   0.08   0.08   0.08   0.08       Tap Density (g/cc)   0.15   0.13   0.14   0.13                    
Values for FPF, gPSD, bulk density, and tap density for all four maltodextrin powders are observed to stay consistent for all four Maltodextrins.
 
     2. Spray Dryer Outlet Temperature of 60° C. 
     Seven Maltodextrins are evaluated at 60° C.—SD-30, SD-60, M-100, M-150, M-180, M-200, and M-250. The Aqueous:Organic ratio was maintained at 20:80 v:v at a total liquid flow rate of 40 mL/min. Process parameters listed in Table 42 are used to produce this powder. Results from this evaluation are shown in Table 16 below. 
                     TABLE 16                  Aerosol results from Sumatriptan succinate powders spray dried at 60° C.                                             Lot Number   155059   155060   155061   155062   155063   155064   155065                                                     Total solid   4   4   4   4   4   4   4       concentration (g/L)                                   Sumatriptan succinate (%)   50   50   50   50   50   50   50       Stabilite SD-30,                           30       Polyglycitol (%)                                   Stabilite SD-60,                       30           Polyglycitol (%)                                   Maltrin M-100,                   30               Maltodextrin (%)                                   Maltrin M-150,               30                   Maltodextrin (%)                                   Maltrin M-180,           30                       Maltodextrin (%)                                   Maltrin M-200,Corn       30                           syrup solids (%)                                   Maltrin M-250,Corn   30                               syrup solids (%)                                   DPPC (%)   18   18   18   18   18   18   18       Sodium chloride (%)   2   2   2   2   2   2   2       Fine particle fraction,   34   48   45   48   46   46   44       &lt;5.6 um (%) (Size 00)                                   Fine particle fraction,   51   54   57   62   62   52   52       &lt;5.6 um (%) (Size 2)                                   Water content (%)   3.43   2.32   2.23   2   2.71   2.86   3.36       gPSD (VMGD 1 bar, mm)   11.2   9.4   7.3   6.1   7   7.2   7.9       Bulk/Aerated Density (g/cc)   0.020   0.033   0.049   0.067   0.072   0.069   0.065       Tap Density (g/cc)   0.033   0.057   0.076   0.085   0.097   0.102   0.088                    
Values for FPF and water content are observed to stay consistent for all four Maltodextrins. However, particles produced with the M-200 and M-250 are observed to have a relatively lower density value and a relatively higher gPSD value as compared to the other maltodextrins.
 
     Example 8: Spray Dryer Setup Configurations 
     This study is conducted to evaluate different spray drying configurations for the production of SD-30 based Sumatriptan succinate formulations. Table 17 below details the spray dryer configurations and the results from evaluating these powders. Parameters used for the production of these powders are listed in Table 43. 
                     TABLE 17                  Sumatriptan succinate powder spray dried with varied spray dryer configurations                                                 Lot Number   155091   155092   155094   155095   155097   155098   155100-1   155100-2                                                         Total solid concentration (g/L)   4   4   4   4   4   4   4   4       Sumatriptan succinate (%)   50   50   50   50   50   50   50   50       Stabilite SD-30,    30   30   30   30   30   30   30   30       Polyglycitol (%)                                       DPPC (%)   18   18   18   18   18   18   18   18       Sodium chloride (%)   2   2   2   2   2   2   2   2       Fine particle fraction, &lt;5.6 um   69   42   68   43                       (%) (Size 00)                                       Fine particle fraction, &lt;5.6 um   80   60   82   56   67   66   84   78       Bulk/Aerated Density (g/cc)           0.079   0.065   0.073   0.086   0.089   0.076       Tap Density (g/cc)           0.113   0.098   0.114   0.132   0.132   0.118       Configuration   Bottom   Top inlet   Bottom   Top   Bottom   Bottom   Bottom   Top inlet           inlet   product   inlet   inlet   inlet   inlet   inlet   product           product   filter    product   product   product   product   product   filter with           filter    with   filter    filter    filter    filter    filter with   Manual           with   Automatic   with   with   with   with   Manual   spray           Manual   spray   Manual   Automatic   Automatic   Automatic   spray   dryer            dryer    dryer    spray   spray   spray   spray   dryer unit   unit           spray    unit   dryer   dryer    dryer    dryer    (control)               unit       unit   unit   unit   unit                   (control)       (control)       (Nozzle #   (Nozzle #                                   1)-Moist   2)-Moist                                   deposits   deposits                                   on piping   on piping                                   observed   observed                    
Additional studies described in the following examples are conducted to evaluate the cause of moist deposits as well as the reason for non-comparable data for powders produced on the Automatic Spray dryer and the Manual Spray dryer.
 
     Example 9: Varied Sumatriptan Succinate Loads at 60° C. Outlet Temperature 
     The effect of Sumatriptan succinate load on the aerosol and solid state properties of spray dried Sumatriptan succinate powder produced at an outlet temperature of 60° C. was evaluated for this study. Sumatriptan succinate load was varied from 50% to 50%, for which the L-leucine or SD-30 load was decreased from 75% to 30%. The DPPC ratio was maintained at 18%, and the Sodium chloride ratio was maintained at 2%. 
     1. L-Leucine Based Formulations 
     Process parameters used for this evaluation are described in Table 44. Table 18 details the results from this evaluation. 
                     TABLE 18                  Varied Sumatriptan succinate load for L-leu based formulation (60 C.)                                                         Lot Number   155104   155105   155106   155107   155108   155109   155110   155111   155112   155113                                                                 Total solid concentration (g/L)   4   4   4   4   4   4   4   4   4   4       Sumatriptan succinate (%)   5   10   15   20   25   30   35   40   45   50       L-leucine (%)   75   70   65   60   55   50   45   40   35   30       DPPC (%)   18   18   18   18   18   18   18   18   18   18       Sodium chloride (%)   2   2   2   2   2   2   2   2   2   2       Fine particle fraction, &lt;5.6 um   77   74   71   70   71   58   61   61   64   66       (%) (Size 2)                                               Water content (%)                                               gPSD (VMGD 1 bar, mm)   2.2   2.3   2.5   2.1   2   2.3   2.4   2.7   3.4   3.1       Bulk/Aerated Density (g/cc)   0.087   0.093   0.087   0.092   0.104   0.104   0.107   0.103   0.103   0.092       Tap Density (g/cc)   0.120   0.134   0.124   0.116   0.135   0.161   0.144   0.128   0.129   0.165                    
As the Sumatriptan succinate increases, the FPF value is observed to decrease slightly and the gPSD is observed to increase slightly. Both bulk and tap density values stay relatively constant.
 
     2. SD-30 Based Formulations 
     Process parameters used for this evaluation are mentioned in Table 45. Table 19 details the results from this evaluation. 
                     TABLE 19                  Varied Sumatriptan succinate load for SD-30 based formulation (60 C.)                                                         Lot Number   155125   155126   155127   155128   155129   155130   155131   155132   155133   155134                                                                 Total solid    4   4   4   4   4   4   4   4   4   4       concentration (g/L)                                               Sumatriptan    5   10   15   20   25   30   35   40   45   50       succinate (%)                                               Stabilite SD-30,    75   70   65   60   55   50   45   40   35   30       Polyglycitol (%)                                               DPPC (%)   18   18   18   18   18   18   18   18   18   18       Sodium chloride (%)   2   2   2   2   2   2   2   2   2   2       Fine particle fraction,    60   55   71   70   76   65   70   70   67   71       &lt;5.6 um (%) (Size 2)                                               Bulk/Aerated    0.093   0.143   0.085   0.098   0.092   0.086   0.081   0.065   0.101   0.096       Density (g/cc)                                               Tap Density (g/cc)   0.120   0.168   0.115   0.130   0.156   0.113   0.111   0.087   0.133   0.166       XRPD       A-T2       A-T2   A-T2   A-T2       A-T2       A-T2       TGA-120 (%)       4.48       3.17   2.67   1.71       1.45       2.14       Low T Endotherm        41.6        42.2    42   42.3       42.5       43.6       1/Tg (° C.)       (sharp)       (sharp)                               Low T Endotherm        none       none   none   61.1        63.2        62.9        2/Tg (° C.)                       (small)       (small)       (small)       Recrystallization        none       none   none   none       none       none       Exotherm (° C.)                                               High T Melt        none       none   none   none       none       none       Endotherm                    
Legend for Solid state data: A-T2: Diffractogram is amorphous with the exception of 1-2 peaks associated with the excipients, Tg: Glass transition intercept
 
     As the Sumatriptan succinate increases, the FPF observed to decrease slightly and the gPSD is observed to increase slightly. Both bulk and tap density values stay relatively constant. 
     Example 10: Stability of SD-30 Formulations Produced at Varied Spray Dryer Outlet Temperatures 
     Three spray dryer outlet temperatures are evaluated with the SD-30 based formulation—44° C., 50° C., and 60° C. Process parameters used for this evaluation are listed in Table 46. Table 20 summarizes the aerosol properties of these formulations at t=0, and t=2 week and 1 month at 40° C. storage conditions. Table 21 summarizes the solid state data over the course of this stability study. 
     
       
         
           
               
             
               
                 TABLE 20 
               
             
            
               
                   
               
               
                 Aerosol data for SD-30 based powders produced 
               
               
                 at varied outlet temperatures 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                   
                 VMGD 
                 FPF 
               
               
                 Lot # 
                 Formulation 
                 Condition 
                 (um) 
                 (%) 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 189065-1 
                 30:50:18:2 
                 t = 0 
                 7.5 
                 60 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 SumatriptanS:SD- 
                 40 C. 
                 1 
                 week 
                   
                 61 
               
               
                   
                 30:DPPC:NaCl 
                   
                 1 
                 month 
                   
                 68 
               
               
                   
                 (Outlet = 60) 
               
            
           
           
               
               
               
               
               
            
               
                 189065-2 
                 30:50:18:2 
                 t = 0 
                 5 
                 69 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 SumatriptanS:SD- 
                 40 C. 
                 1 
                 week 
                   
                 67 
               
               
                   
                 30:DPPC:NaCl 
                   
                 1 
                 month 
                   
                 67 
               
               
                   
                 (Outlet = 50) 
               
            
           
           
               
               
               
               
               
            
               
                 189065-3 
                 30:50:18:2 
                 t = 0 
                 6.2 
                 75 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 SumatriptanS:SD- 
                 40 C. 
                 1 
                 week 
                   
                 73 
               
               
                   
                 30:DPPC:NaCl 
                   
                 1 
                 month 
                   
                 67 
               
               
                   
                 (Outlet = 44) 
               
               
                   
                   
               
            
           
         
       
     
     The FPF value for all three formulations stays consistent throughout the stability evaluation. No evidence of API crystallization/nucleation was observed by XRPD or DSC. Endothermic shifting observed from t=0 with growth of peak in the 50-53 C area, likely due to DPPC phase transition/transformation. All samples have consistent weight loss by TGA. No clear physical differences between formulations from solid state characterization. 189065-1 (highest outlet) may have higher % of initial “transformed” DPPC as evident by 2nd endotherm (˜50&#39;s C) and what appears to be less thermal crystallization. 
     
       
         
           
               
             
               
                 TABLE 21 
               
             
            
               
                   
               
               
                 Solid state data for SD-30 based powders produced at varied outlet temperatures 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 TGA-120 
                 Low T 1 
                 Low T 2 
                 Recryst.  
                 Recryst. 
                 Melt  
               
               
                 Lot # 
                 Formulation 
                 Condition 
                 XRPD 
                 (%) 
                 (° C.) 
                 (° C.) 
                 (° C.) 
                 ΔH (J/g) 
                 (° C.) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 189065-1 
                 30:50:18:2 
                 t = 0 
                 A-T2 
                 2.39 
                 38.1 (Tg) 
                 41.8, 58.7 
                 unclear 
                 n.c. 
                 none 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 SumatriptanS:SD-30: 
                 40 C. 
                 1 week 
                 A-T2 
                 1.78 
                 39.6 (Tg) 
                 42.4, 52.8 
                 none 
                 none 
                 none 
               
               
                   
                 DPPC:NaCl  
                   
                 1 month 
                 A-T2 
                 1.71 
                 39.7 (Tg) 
                 42.7, 54.2 
                 none 
                 none 
                 none 
               
               
                   
                 (Outlet = 60) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 189065-2 
                 30:50:18:2 
                 t = 0 
                 A-T2 
                 2.22 
                 38.7 (Tg) 
                 41.6 
                 67.7 
                 n.c. 
                 none 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 SumatriptanS:SD-30: 
                 40 C. 
                 1 week 
                 A-T2 
                 1.69 
                 39.7 (Tg) 
                 42.6, 53.0 
                 69.8 (broad) 
                 n.c. 
                 none 
               
               
                   
                 DPPC:NaCl  
                   
                 1 month 
                 A-T2 
                 1.80 
                 40.0 (Tg) 
                 42.9, 54.0 
                 69.9 (broad) 
                 n.c. 
                 none 
               
               
                   
                 (Outlet = 50) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 189065-3 
                 30:50:18:2 
                 t = 0 
                 A-T2 
                 1.96 
                 38.6 (Tg) 
                 41.6 
                 67.9 (broad) 
                 n.c. 
                 Unk 153, 164 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 SumatriptanS:SD-30: 
                 40 C. 
                 1 week 
                 A-T2 
                 1.57 
                 40.3 (Tg) 
                 42.7, 53.1* 
                 74.2 (broad) 
                 n.c. 
                 none 
               
               
                   
                 DPPC:NaC1  
                   
                 1 month 
                 A-T2 
                 1.39 
                 40.6 (Tg) 
                 43.2, 53.9 
                 73.5 (broad) 
                 n.c. 
                 none 
               
               
                   
                 (Outlet = 44) 
               
               
                   
               
               
                 1. “n.c.” = not calculated due to size, shape, or proximity to other events. Event is small 
               
               
                 2. Unk = unknown events possibly related to artifacts or small melts from thermal crystallization (not observed in 40 C. samples). 
               
               
                 3. *estimated value 
               
               
                 4. A-T2: Diffractogram is amorphous with the exception of 1-2 peaks associated with the excipients 
               
               
                 5. Tg: Glass transition intercept. 
               
            
           
         
       
     
     Example 11: Comparison of Formulations Produced with a 6-Hole Air Cap and a 1-Hole Air Cap 
     This evaluation was conducted to compare the stability two variations over 3 months at 40° C.—(i) varied air cap configurations with varied Aqueous:Organic ratios at a higher outlet temperature, and (ii) varied outlet temperatures with same air-cap configurations. Both the SD-30 based formulations and the L-leucine formulations were evaluated. 
     1. SD-30 Based Formulations 
     Table 22 summarizes the aerosol stability data and Table 23 summarizes the solid state stability data. Process parameters used for the production of the 6-hole air cap formulation are listed in Table 47. Process parameters used for the production of the 1-hole air cap formulations are listed in Table 48. 
                     TABLE 22                  Aerosol data for SD-30 based formulations evaluated        for Air cap config, Aq:Org ratio and Outlet temp.                                                     VMGD   pBulk    pTap    FPF        Lot #   Formulation   Condition   (um)   (g/cc)   (g/cc)   (%)                                                 189111   30:50:18:2   t = 0   6.3   0.04   0.05   59                                                 SumatriptanS:   20 C.   2 week   7.6           66           SD-30:DPPC:       1 month   7.3           71           NaCl (6-hole       3 month               65           air cap,       6 month                           60 C. outlet)   40 C.   2 week   6.9           63                   1 month   6.4           58                   3 month               56                   6 month                                                         189107   30:50:18:2   t = 0   4.3   0.05   0.07   68                                                 SumatriptanS:   20 C.   2 week   4           81           SD-30:DPPC:       1 month   4.6           73           NaCl (1-hole        3 month               71           air cap,       6 month                           60 C. outlet)   40 C.   2 week   4.3           65                   1 month   4           57                   3 month               58                   6 month                                                         189108   30:50:18:2   t = 0   3.5   0.07   0.09   70                                                 SumatriptanS:   20 C.   2 week   3.4           86           SD-30 :DPPC:       1 month   3.3           77           NaCl (1-hole        3 month               72           air cap,       6 month                           45 C. outlet)   40 C.   2 week   3.5           66                   1 month   3.3           61                   3 month               59                   6 month                    
The FPF value of all three formulations is observed to drop down significantly over the course of 3 months. Similar solid state characteristics observed across all lots. No API crystallization observed (XRD) except for a single peak at ˜21 2Theta. Small thermal recrystallization peaks observed. No melting due to thermal recrystallization observed up to 180 C. Endothermic shifting observed from t=0 which is likely due to DPPC phase transition (most evident in 40 C samples). Lot S189108 (1-hole, 45 C) has a slightly higher moisture content than Lot S189107 (1-hole, 60 C) which is likely due to the outlet temperature.
 
     
       
         
           
               
             
               
                 TABLE 23 
               
             
            
               
                   
               
               
                 Solid state data for SD-30 based formulations evaluated for Air cap config, Aq:Org ratio and Outlet temp. 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 TGA- 
                   
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 120 
                 Low T 1 
                 Low T 2 
                 Recryst.  
                 Recryst. 
                 Melt 
               
               
                 Lot # 
                 Formulation 
                 Condition 
                 XRPD 
                 (%) 
                 (° C.) 
                 (° C.) 
                 (° C.) 
                 ΔH (J/g) 
                 (° C.) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 189111 
                 30:50:18:2 
                 t = 0 
                 A-T2 
                 2.41 
                 39.8  
                 (Tg) 
                 42.2 
                 67.0 (small) 
                 n.c. 
                 none 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 SumatriptanS: 
                 20 C. 
                 2 week 
                 A-T2 
                 2.33 
                 42.3  
                 (Tg) 
                 44.0 
                 68.6 (small) 
                 n.c. 
                 none 
               
               
                   
                 SD-30:DPPC: 
                   
                 1 month 
                 A-T2 
                 1.96 
                 41.5  
                 (Tg) 
                 43.7 
                 73.3 (small) 
                 n.c. 
                 none 
               
               
                   
                 NaCl (6-hole 
                   
                 3 month 
                 A-T2 
                 1.59 
                 43.3  
                 (Tg) 
                 45.2 
                 47.3, 55.4, 74.2 
                 n.c., n.c., n.c. 
                 none 
               
               
                   
                 air cap,  
                   
                 6 month 
                 A-T2 
                 1.65 
                 41.7  
                 (Tg) 
                 44.3 
                 66 
                 n.c. 
                 none 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 60 C. outlet) 
                 40 C. 
                 2 week 
                 A-T2 
                 1.53 
                 Unclear 
                 49.5 
                 none 
                 none 
                 none 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                 1 month 
                 A-T2 
                 1.98 
                 40.9  
                 (Tg  
                 51.0 
                 67.9 (small) 
                 n.c. 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                   
                 shoulder)** 
                   
                   
                   
                   
               
               
                   
                   
                   
                 3 month 
                 A-T2 
                 1.56 
                 48.5  
                 (Tg) 
                 52.7 
                 68.5, 100.8 
                 n.c., n.c. 
                 none 
               
               
                   
                   
                   
                 6 month 
                 A-T2 
                 1.76 
                 47.3  
                 (Tg) 
                 53.5 
                 66.9 
                 n.c. 
                 154 (?) 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 189107 
                 30:50:18:2 
                 t = 0 
                 A-T2 
                 0.96 
                 40.7  
                 (Tg) 
                 43.3, 45.6 
                 75.7, 148.3 
                 n.c., 0.33 
                 none 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 SumatriptanS: 
                 20 C. 
                 2 week 
                 A-T2 
                 1.78 
                 43.1  
                 (Tg) 
                 44.2 
                 65.8, 146.6 
                 n.c., n.c 
                 none 
               
               
                   
                 SD-30:DPPC: 
                   
                 1 month 
                 A-T2 
                 1.50 
                 41.5  
                 (Tg) 
                 44.6, 57.8 
                 69.9, 145.6 
                 n.c., n.c 
                 none 
               
               
                   
                 NaCl (1-hole 
                   
                 3 month 
                 A-T2 
                 1.32 
                 46.8  
                 (Tg) 
                 49.5, 63.2, 
                 77.1, 146.7 
                 n.c., n.c 
                 none 
               
               
                   
                 air cap,  
                   
                   
                   
                   
                   
                   
                 90.2, 107.3 
                   
                   
                   
               
               
                   
                 60 C. outlet) 
                   
                 6 month 
                 A-T2 
                 1.41 
                 43.4  
                 (Tg) 
                 46.1, 61.7 
                 72.4 
                 n.c. 
                 none 
               
               
                   
                   
                 40 C. 
                 2 week 
                 A-T2 
                 1.48 
                 47.6  
                 (Tg) 
                 52.0 
                 81.0, 143.8 
                 n.c., n.c. 
                 none 
               
               
                   
                   
                   
                 1 month 
                 A-T2 
                 1.68 
                 47.6  
                 (Tg) 
                 52.9 
                 90.6, 142.4 
                 n.c, n.c 
                 none 
               
               
                   
                   
                   
                 3 month 
                 A-T2 
                 1.53 
                 48.6  
                 (Tg) 
                 55.6 
                 92.6, 141.8 
                 n.c., n.c. 
                 none 
               
               
                   
                   
                   
                 6 month 
                 A-T2 
                 1.59 
                 50.6  
                 (Tg)**** 
                 55.1 
                 68.1, 87.2, 139.4 
                 n.c., n.c., n.c. 
                 none 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 189108 
                 30:50:18:2 
                 t = 0 
                 A-T2 
                 1.72 
                 41.6 
                 (Tg) 
                 43.8, 44.8 
                 53.7, 70.1, 152.2 
                 n.c., n.c., 0.34 
                 none 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 SumatriptanS: 
                 20 C. 
                 2 week 
                 A-T2 
                 2.21 
                 41.4  
                 (Tg) 
                 44.6, 48.4 
                 70.3, 152.3 
                 n.c., n.c. 
                 none 
               
               
                   
                 SD-30:DPPC: 
                   
                 1 month 
                 A-T2 
                 1.90 
                 41.9  
                 (Tg) 
                 45.1, 56.3 
                 71.5 
                 n.c. 
                 none 
               
               
                   
                 NaCl (1-hole 
                   
                 3 month 
                 A-T2 
                 1.42 
                 46.4  
                 (Tg) 
                 48.9, 61.0 
                 74.9, 147.2 
                 n.c., n.c. 
                 none 
               
               
                   
                 air cap, 
                   
                 6 month 
                 A-T2 
                 1.72 
                 42.8  
                 (Tg) 
                 45.3, 58.7 
                 70.6, 148.2 
                 n.c., n.c. 
                 none 
               
               
                   
                 45 C. outlet) 
                 40 C. 
                 2 week 
                 A-T2 
                 1.97 
                 47.3  
                 (Tg) 
                 51.6 
                 148.0 
                 0.237 
                 None 
               
               
                   
                   
                   
                 1 month 
                 A-T2 
                 2.04 
                 48.2  
                 (Tg)*** 
                 52.8 
                 91.4 
                 n.c. 
                 none 
               
               
                   
                   
                   
                 3 month 
                 A-T2 
                 1.63 
                 48.1  
                 (Tg1), 
                 54.9 
                 66.9, 93.5, 141.4 
                 n.c., n.c., n.c. 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 53.6  
                 (Tg2) 
                   
                   
                   
                   
               
               
                   
                   
                   
                 6 month 
                 A-T2 
                 1.7 
                 43.3  
                 (Tg)**** 
                 55.3 
                 67.8, 105.4 
                 n.c., n.c. 
                 none 
               
               
                   
               
               
                 1. “n.c.” = not calculated due to size, shape, or proximity to other events. Event is small. 
               
               
                 2. Unk = unknown events possibly related to artifacts or small melts from thermal crystallization (not observed in 40 C. samples). 
               
               
                 3. A-T2: Diffractogram is amorphous with the exception of 1-2 peaks associated with the excipients 
               
               
                 4. Tg: Glass transition intercept 
               
               
                 5. **Tg for 189111 1M40C is calcualted as part of a shoulder within the endotherm. This method may not accurately reflect the correct Tg value of this event is a true Tg. 
               
               
                 6. ***Tg for 189108 1M40C shows shoulder within endotherm indicating the Tg value may be lower than what is reported. 
               
            
           
         
       
     
     2. L-Leucine Based Formulations 
     Two Sumatriptan succinate loads are evaluated with L-leucine—20% and 30%. Table 25 summarizes the aerosol data and Table 26 summarizes the solid state data at t=0 and over the course of one month storage at both 20 C and 40 C (With time points at 2 weeks and 1 month). Process parameters used for the production of these 1-hole air cap formulations are listed in Table 48. 
                                             TABLE 25               Lot #   Formulation   Condition   VMGD (um)   pBulk (g/cc)   pTap (g/cc)   FPF (%)                  189121   20:60:18:2   t = 0   12.4   0.07   0.09   49                                                     Sumatriptan   20 C.   Capsules   1 week   13.2           53           succinate:           2 weeks   12.7           49           L-leucine:           1 month   12.3           46           DPPC:NaCl       Bulk   1 week               59                   powder   2 weeks               53                   in vials   1 month               45               40 C.   Capsules   1 week   12.9           42                       2 weeks   14.5           41                       1 month   13.7           34                   Bulk   1 week               45                   powder   2 weeks               68                   in vials   1 month               39                                         189122   30:50:18:2   t = 0   11.2   0.07   0.12   48                                                     Sumatriptan   20 C.   Capsules   1 week   11.8           51           succinate:           2 weeks   11.4           50           L-leucine:           1 month   11.4           44           DPPC:NaCl       Bulk   1 week               49                   powder   2 weeks               49                   in vials   1 month               48               40 C.   Capsules   1 week   15.3           39                       2 weeks   15.3           39                       1 month   15.6           33                   Bulk   1 week               45                   powder   2 weeks               44                   in vials   1 month               38                    
The FPF values are consistently lower than the SD-30 based formulation. The gPSD values are significantly higher than the SD-30 based formulation. No evidence of API crystallization/nucleation observed except for 40 C 1 Month Capsule for 189121 shows hint of nucleation by XRD. Unclear glass transition behavior, potential sub Tg events. The value that was initially calculated as “sub Tg” may in fact be the Tg or potentially one of the Tg events in a multi Tg systems (which would indicate a lack of homogeneity). Potential thermal crystallization of API observed by DSC in the 80-150 C region. Weight loss by TGA remains stable though 1M samples show systemic drop in weight loss.
 
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 26 
               
               
                   
               
               
                   
                   
                   
                   
                 TGA- 
                   
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 120 
                 Low T 1 
                 Low T 2 
                 Recryst.  
                 Recryst. 
                 Melt 
               
               
                 Lot # 
                 Formulation 
                 Condition 
                 XRPD 
                 (%) 
                 (° C.) 
                 (° C.) 
                 (° C.) 
                 ΔH (J/g) 
                 (° C.) 
               
               
                   
               
             
            
               
                 189121 
                 20:60:18:2 
                 t = 0 
                 PC-T2 
                 0.96 
                 no clear Tg 
                 51.6, 63.2 
                 none 
                 none 
                 none 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 Sumatriptan 
                 20 C. 
                 Capsules 
                 1 week 
                 PC-T2 
                 1.08 
                 no clear Tg 
                 51.1, 63.1 
                 none 
                 none 
                 none 
               
               
                   
                 succinate: 
                   
                   
                 2 weeks 
                 PC-T2 
                 0.94 
                 no clear Tg 
                 50.9, 63.1 
                 83.2 (broad) 
                 n.c. 
                 none 
               
               
                   
                 L-leucine: 
                   
                   
                 1 month 
                 PC-T2 
                 0.21 
                 34.3 (Tg? 
                 52.3, 62.8 
                 none 
                 none 
                 none 
               
               
                   
                 DPPC:NaCl 
                   
                   
                   
                   
                   
                 unclear) 
                   
                   
                   
                   
               
               
                   
                   
                   
                 Bulk 
                 1 week 
                 NT 
                 NT 
                 NT 
                 NT 
                 NT 
                 NT 
                 NT 
               
               
                   
                   
                   
                 powder 
                 2 weeks 
                 PC-T2 
                 1.19 
                 no clear Tg 
                 51.4, 63.4 
                 81.5 (broad) 
                 n.c. 
                 none 
               
               
                   
                   
                   
                 in vials 
                 1 month 
                 PC-T2 
                 0.50 
                 36.3 (Tg? 
                 54.0, 64.0 
                 small (broad) 
                 n.c. 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                   
                 unclear) 
                   
                   
                   
                   
               
               
                   
                   
                 40 C. 
                 Capsules 
                 1 week 
                 PC-T2 
                 1.21 
                 no clear Tg 
                 50.1, 63.7 
                 149.6 
                 11.2 
                 none 
               
               
                   
                   
                   
                   
                 2 weeks 
                 PC-T2 
                 1.11 
                 no clear Tg 
                 51.6, 63.9 
                 98.3, 146.1 
                 n.c. 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (unclear) 
                   
                   
               
               
                   
                   
                   
                   
                 1 month 
                 PC 
                 0.56 
                 27.4 (sub Tg?) 
                 52.2. 64.1 
                 99.2 (broad) 
                 n.c. 
                 none 
               
               
                   
                   
                   
                 Bulk 
                 1 week 
                 NT 
                 NT 
                 NT 
                 NT 
                 NT 
                 NT 
                 NT 
               
               
                   
                   
                   
                 powder 
                 2 weeks 
                 PC-T2 
                 1.15 
                 no clear Tg 
                 51.6, 63.8 
                 88.2, 144.2 
                 n.c. 
                 none 
               
               
                   
                   
                   
                 in vials 
                   
                   
                   
                   
                   
                 (unclear) 
                   
                   
               
               
                   
                   
                   
                   
                 1 month 
                 PC-T2 
                 0.35 
                 35.9 (sub Tg?) 
                 52.8, 63.6 
                 small (broad) 
                 n.c. 
                 none 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 189122 
                 30:50:18:2 
                 t = 0 
                 PC-T2 
                 1.28 
                 no clear Tg 
                 51.1, 63.2 
                 none 
                 none 
                 none 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 Sumatriptan 
                 20 C. 
                 Capsules 
                 1 week 
                 PC-T2 
                 1.02 
                 no clear Tg 
                 50.4, 62.8 
                 none 
                 none 
                 none 
               
               
                   
                 succinate: 
                   
                   
                 2 weeks 
                 PC-T2 
                 1.18 
                 no clear Tg 
                 50.1, 62.6 
                 unclear (broad) 
                 n.c. 
                 none 
               
               
                   
                 L-leucine: 
                   
                   
                 1 month 
                 PC-T2 
                 0.51 
                 29.3 (sub Tg?) 
                 50.9, 62.2 
                 unclear (broad) 
                 n.c. 
                 none 
               
               
                   
                 DPPC:NaCl 
                   
                 Bulk 
                 1 week 
                 NT 
                 NT 
                 NT 
                 NT 
                 NT 
                 NT 
                 NT 
               
               
                   
                   
                   
                 Powder 
                 2 weeks 
                 PC-T2 
                 1.51 
                 no clear Tg 
                 50.7, 62.9 
                 unclear (broad) 
                 n.c. 
                 none 
               
               
                   
                   
                   
                 in vials 
                 1 month 
                 PC-T2 
                 0.40 
                 26.8 (sub Tg?) 
                 51.2, 62.6 
                 unclear (broad) 
                 n.c. 
                 none 
               
               
                   
                   
                 40 C. 
                 Capsules 
                 1 week 
                 PC-T2 
                 1.41 
                 no clear Tg 
                 50.0, 63.7 
                 150.6 
                 1.87 
                 none 
               
               
                   
                   
                   
                   
                 2 weeks 
                 PC-T2 
                 1.47 
                 no clear Tg 
                 49.4, 63.2 
                 92.3 (small, 
                 n.c. 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 broad?) 
                   
                   
               
               
                   
                   
                   
                   
                 1 month 
                 PC-T2 
                 0.82 
                 30.8 (sub Tg?) 
                 52.2, 63.1 
                 100 (broad),  
                 n.c. 
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                 no clear Tg 
                   
                 154, 170 
                   
                   
               
               
                   
                   
                   
                 Bulk 
                 1 week 
                 NT 
                 NT 
                 NT 
                 NT 
                 NT 
                 NT 
                 NT 
               
               
                   
                   
                   
                 powder 
                 2 weeks 
                 PC-T2 
                 1.60 
                 no clear Tg 
                 50.7, 63.4 
                 none 
                 none 
                 none 
               
               
                   
                   
                   
                 in vials 
                 1 month 
                 PC-T2 
                 0.41 
                 34.2 (sub Tg?) 
                 51.6, 62.5 
                 100 broad, 167 
                 n.c 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                   
                 no clear Tg 
                   
                   
                   
                   
               
               
                   
               
               
                 1. “n.c.” = not calculated due to size, shape, or proximity to other events. Event is small. 
               
               
                 2. A-T2: Diffractogram is amorphous with the exception of 1-2 peaks associated with the excipients 
               
               
                 3. Tg: Glass transition intercept 
               
               
                 4. *** Drop in Tg may be due to appearance of separation between Tg and initial endotherm, which in previous samples overlapped resulting in a higher Tg intercept calculation. 
               
               
                 5. The value that was initially calculated as “sub Tg” may in fact be the Tg or potentially one of the Tg events in a multi Tg systems (which would indicate a lack of homogeneity) 
               
            
           
         
       
     
     2. Spray Drying Process Parameters 
       
     
       
         
           
               
               
               
               
               
             
               
                   
                 TABLE 27 
               
               
                   
                   
               
               
                   
                 Lot Number 
                 117048 
                 117049 
                 117050 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Total solid concentration (g/L) 
                 4 
                 4 
                 4 
               
               
                   
                 Inlet Temperature (° C.) 
                 78 
                 78 
                 78 
               
               
                   
                 Outlet Temperature (° C.) 
                 44 
                 44 
                 44 
               
               
                   
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
               
               
                   
                 Atomization Gas Flow Rate 
                 22 
                 22 
                 22 
               
               
                   
                 (g/min) 
               
               
                   
                 Aqueous Flow (mL/min) 
                 8 
                 8 
                 8 
               
               
                   
                 Organic flow (mL/min) 
                 32 
                 32 
                 32 
               
               
                   
                 Product filter purge gas flow 
                 15 
                 15 
                 15 
               
               
                   
                 (scfh) 
               
               
                   
                 Sumatriptan succinate (%) 
                 5 
                 20 
                 50 
               
               
                   
                 L-leucine (%) 
                 75 
                 60 
                 30 
               
               
                   
                 DPPC (%) 
                 18 
                 18 
                 18 
               
               
                   
                 Sodium chloride (%) 
                 2 
                 2 
                 2 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 28 
               
               
                   
                   
               
               
                   
                 Lot Number 
                 117072 
                 117073 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Total solid concentration (g/L) 
                 4 
                 4 
               
               
                   
                 Inlet Temperature (° C.) 
                 78 
                 106 
               
               
                   
                 Outlet Temperature (° C.) 
                 44 
                 60 
               
               
                   
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
               
               
                   
                 Atomization Gas Flow Rate 
                 22 
                 22 
               
               
                   
                 (g/min) 
               
               
                   
                 Aqueous Flow (mL/min) 
                 8 
                 8 
               
               
                   
                 Organic flow (mL/min) 
                 32 
                 32 
               
               
                   
                 Product filter purge gas flow 
                 15 
                 15 
               
               
                   
                 (scfh) 
               
               
                   
                 Sumatriptan succinate (%) 
                 80 
                 80 
               
               
                   
                 L-leucine (%) 
               
               
                   
                 DPPC (%) 
                 18 
                 18 
               
               
                   
                 Sodium chloride (%) 
                 2 
                 2 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 29 
               
               
                   
               
               
                 Lot Number 
                 117077 
                 117078 
                 117079 
                 117080 
                 117081 
                 117082 
                 117083 
                 117084 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 Total solid 
                 2 
                 4 
                 6 
                 4 
                 2 
                 4 
                 6 
                 4 
               
               
                 concentration (g/L) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Inlet Temperature (° C.) 
                 78 
                 91 
                 100 
                 108 
                 78 
                 85 
                 95 
                 104 
               
               
                 Outlet Temperature 
                 44 
                 44 
                 44 
                 44 
                 44 
                 44 
                 44 
                 44 
               
               
                 (° C.) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Drying Gas Rate 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 (kg/hr) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Atomization Gas Flow 
                 22 
                 22 
                 22 
                 22 
                 22 
                 22 
                 22 
                 22 
               
               
                 Rate (g/min) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Aqueous Flow 
                 8 
                 16 
                 24 
                 32 
                 8 
                 16 
                 24 
                 32 
               
               
                 (mL/min) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Organic flow (mL/min) 
                 32 
                 24 
                 16 
                 8 
                 32 
                 24 
                 16 
                 8 
               
               
                 Secondary drying gas 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 flow (kg/hr) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Secondary drying gas 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 temperature (° C.) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Product filter purge gas 
                 15 
                 15 
                 15 
                 15 
                 15 
                 15 
                 15 
                 15 
               
               
                 flow (scfh) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
                 2850 
                 2850 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 30 
               
               
                   
               
               
                 Lot Number 
                 117091 
                 117092 
                 117093 
                 117094 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Total solid concentration 
                 2 
                 4 
                 2 
                 4 
               
               
                 (g/L) 
               
               
                 Inlet Temperature (° C.) 
                 83 
                 84.5 
                 93 
                 94 
               
               
                 Outlet Temperature 
                 44 
                 44 
                 44 
                 44 
               
               
                 (° C.) 
               
               
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
                 100 
               
               
                 Atomization Gas Flow 
                 22 
                 22 
                 22 
                 22 
               
               
                 Rate (g/min) 
               
               
                 Aqueous Flow (mL/min) 
                 16 
                 16 
                 24 
                 24 
               
               
                 Organic flow (mL/min) 
                 24 
                 24 
                 16 
                 16 
               
               
                 Secondary drying gas 
                 50 
                 50 
                 50 
                 50 
               
               
                 flow (kg/hr) 
               
               
                 Secondary drying gas 
                 44 
                 44 
                 44 
                 44 
               
               
                 temperature (° C.) 
               
               
                 Product filter purge gas 
                 15 
                 15 
                 15 
                 15 
               
               
                 flow (scfh) 
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6-20- 
                 67-6-20- 
                 67-6-20- 
                 67-6-20- 
               
               
                   
                 150 
                 150 
                 150 
                 150 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 31 
               
               
                   
               
               
                 Lot Number 
                 117103 
                 117104 
                 117105 
                 117106 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Total solid concentration 
                 2 
                 4 
                 2 
                 4 
               
               
                 (g/L) 
               
               
                 Inlet Temperature (° C.) 
                 87 
                 87 
                 99 
                 99 
               
               
                 Outlet Temperature 
                 44 
                 44 
                 44 
                 44 
               
               
                 (° C.) 
               
               
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
                 100 
               
               
                 Atomization Gas Flow 
                 22 
                 22 
                 22 
                 22 
               
               
                 Rate (g/min) 
               
               
                 Aqueous Flow (mL/min) 
                 16 
                 16 
                 24 
                 24 
               
               
                 Organic flow (mL/min) 
                 24 
                 24 
                 16 
                 16 
               
               
                 Secondary drying gas 
                 50 
                 50 
                 50 
                 50 
               
               
                 flow (kg/hr) 
               
               
                 Secondary drying gas 
                 44 
                 44 
                 44 
                 44 
               
               
                 temperature (° C.) 
               
               
                 Product filter purge gas 
                 15 
                 15 
                 15 
                 15 
               
               
                 flow (scfh) 
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6-20- 
                 67-6-20- 
                 67-6-20- 
                 67-6-20- 
               
               
                   
                 150 
                 150 
                 150 
                 150 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 32 
               
               
                   
               
               
                 Lot Number 
                 117107 
                 117108 
                 117109 
                 117110 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Total solid concentration 
                 2 
                 4 
                 2 
                 4 
               
               
                 (g/L) 
               
               
                 Inlet Temperature (° C.) 
                 87 
                 87 
                 99 
                 99 
               
               
                 Outlet Temperature (° C.) 
                 44 
                 44 
                 44 
                 44 
               
               
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
                 100 
               
               
                 Atomization Gas Flow Rate 
                 22 
                 22 
                 22 
                 22 
               
               
                 (g/min) 
               
               
                 Aqueous Flow (mL/min) 
                 16 
                 16 
                 24 
                 24 
               
               
                 Organic flow (mL/min) 
                 24 
                 24 
                 16 
                 16 
               
               
                 Secondary drying gas flow 
                 50 
                 50 
                 50 
                 50 
               
               
                 (kg/hr) 
               
               
                 Secondary drying gas 
                 44 
                 44 
                 44 
                 44 
               
               
                 temperature (° C.) 
               
               
                 Product filter purge gas flow 
                 15 
                 15 
                 15 
                 15 
               
               
                 (scfh) 
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6- 
                 67-6- 
                 67-6- 
                 67-6- 
               
               
                   
                 20-150 
                 20-150 
                 20-150 
                 20-150 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                 TABLE 33 
               
               
                   
               
               
                 Lot Number 
                 117153-1 
                 117153-2 
                 117153-3 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Total solid concentration (g/L) 
                 4 
                 4 
                 4 
               
               
                 Inlet Temperature (° C.) 
                 78 
                 78 
                 78 
               
               
                 Outlet Temperature (° C.) 
                 44 
                 44 
                 44 
               
               
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
               
               
                 Atomization Gas Flow Rate (g/min) 
                 22 
                 33 
                 44 
               
               
                 Aqueous Flow (mL/min) 
                 8 
                 8 
                 8 
               
               
                 Organic flow (mL/min) 
                 32 
                 32 
                 32 
               
               
                 Secondary drying gas flow (kg/hr) 
                 0 
                 0 
                 0 
               
               
                 Secondary drying gas temperature 
                 0 
                 0 
                 0 
               
               
                 (° C.) 
               
               
                 Product filter purge gas flow (scfh) 
                 15 
                 15 
                 15 
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6- 
                 67-6- 
                 67-6- 
               
               
                   
                 20-150 
                 20-150 
                 20-150 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 34 
               
               
                   
               
               
                 Lot Number 
                 117177 
                 117178 
                 117179 
                 117180 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Total solid concentration 
                 4 
                 4 
                 4 
                 4 
               
               
                 (g/L) 
               
               
                 Inlet Temperature (° C.) 
                 78 
                 78 
                 78 
                 78 
               
               
                 Outlet Temperature (° C.) 
                 44 
                 44 
                 44 
                 44 
               
               
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
                 100 
               
               
                 Atomization Gas Flow 
                 44 
                 44 
                 44 
                 44 
               
               
                 Rate (g/min) 
               
               
                 Aqueous Flow (mL/min) 
                 8 
                 8 
                 8 
                 8 
               
               
                 Organic flow (mL/min) 
                 32 
                 32 
                 32 
                 32 
               
               
                 Secondary drying gas flow 
                 0 
                 0 
                 0 
                 0 
               
               
                 (kg/hr) 
               
               
                 Secondary drying gas 
                 0 
                 0 
                 0 
                 0 
               
               
                 temperature (° C.) 
               
               
                 Product filter purge gas 
                 15 
                 15 
                 15 
                 15 
               
               
                 flow (scfh) 
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6- 
                 67-6- 
                 67-6- 
                 67-6- 
               
               
                   
                 20-150 
                 20-150 
                 20-150 
                 20-150 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 35 
               
               
                   
               
               
                 Lot Number 
                 117186 
                 117188 
                 117190 
                 117191 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Total solid concentration 
                 6 
                 6 
                 6 
                 6 
               
               
                 (g/L) 
               
               
                 Inlet Temperature (° C.) 
                 86 
                 87 
                 86 
                 87 
               
               
                 Outlet Temperature (° C.) 
                 44 
                 44 
                 44 
                 44 
               
               
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
                 100 
               
               
                 Atomization Gas Flow Rate 
                 44 
                 44 
                 44 
                 44 
               
               
                 (g/min) 
               
               
                 Aqueous Flow (mL/min) 
                 16 
                 16 
                 16 
                 16 
               
               
                 Organic flow (mL/min) 
                 24 
                 24 
                 24 
                 24 
               
               
                 Secondary drying gas flow 
                 0 
                 0 
                 0 
                 0 
               
               
                 (kg/hr) 
               
               
                 Secondary drying gas 
                 0 
                 0 
                 0 
                 0 
               
               
                 temperature (° C.) 
               
               
                 Product filter purge gas flow 
                 15 
                 15 
                 15 
                 15 
               
               
                 (scfh) 
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6- 
                 67-6- 
                 67-6- 
                 67-6- 
               
               
                   
                 20-150 
                 20-150 
                 20-150 
                 20-150 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 36 
               
               
                   
               
               
                 Lot Number 
                 117164 
                 117165 
                 117166 
                 117167 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Total solid concentration 
                 6 
                 6 
                 6 
                 6 
               
               
                 (g/L) 
               
               
                 Inlet Temperature (° C.) 
                 89 
                 89 
                 89 
                 89 
               
               
                 Outlet Temperature (° C.) 
                 44 
                 44 
                 44 
                 44 
               
               
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
                 100 
               
               
                 Atomization Gas Flow Rate 
                 44 
                 44 
                 44 
                 44 
               
               
                 (g/min) 
               
               
                 Aqueous Flow (mL/min) 
                 16 
                 16 
                 16 
                 16 
               
               
                 Organic flow (mL/min) 
                 24 
                 24 
                 24 
                 24 
               
               
                 Secondary drying gas flow 
                 0 
                 0 
                 0 
                 0 
               
               
                 (kg/hr) 
               
               
                 Secondary drying gas 
                 0 
                 0 
                 0 
                 0 
               
               
                 temperature (° C.) 
               
               
                 Product filter purge gas flow 
                 15 
                 15 
                 15 
                 15 
               
               
                 (scfh) 
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67147 
                 67147 
                 67147 
                 67147 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE 37 
               
               
                   
               
               
                 Lot Number 
                 155039 
                 155040 
                 155034 
                 155035 
                 155036 
                 155037 
                 155038 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Total solid  
                 4 
                 4 
                 4 
                 4 
                 4 
                 4 
                 4 
               
               
                 concentration (g/L) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Inlet Temperature (° C.) 
                 79 
                 79 
                 79 
                 79 
                 79 
                 79 
                 79 
               
               
                 Outlet Temperature (° C.) 
                 44 
                 44 
                 44 
                 44 
                 44 
                 44 
                 44 
               
               
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 Atomization Gas  
                 33 
                 33 
                 33 
                 33 
                 33 
                 33 
                 33 
               
               
                 Flow Rate (g/min) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Aqueous Flow (mL/min) 
                 8 
                 8 
                 8 
                 8 
                 8 
                 8 
                 8 
               
               
                 Organic flow (mL/min) 
                 32 
                 32 
                 32 
                 32 
                 32 
                 32 
                 32 
               
               
                 Secondary drying gas 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 flow (kg/hr) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Secondary drying gas 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 temperature (° C.) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Product filter purge  
                 15 
                 15 
                 15 
                 15 
                 15 
                 15 
                 15 
               
               
                 gas flow (scfh) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6-20-150 
                   
                   
                   
                   
                   
                   
               
               
                 Fluid cap 
                 2850 
                   
                   
                   
                   
                   
                   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 38 
               
               
                   
               
               
                 Lot Number 
                 155046 
                 155047 
                 155048 
                 155049 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Total solid concentration 
                 4 
                 4 
                 4 
                 4 
               
               
                 (g/L) 
               
               
                 Inlet Temperature (° C.) 
                 81 
                 100 
                 81 
                 100 
               
               
                 Outlet Temperature (° C.) 
                 44 
                 60 
                 44 
                 60 
               
               
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
                 100 
               
               
                 Atomization Gas Flow Rate 
                 22 
                 22 
                 22 
                 22 
               
               
                 (g/min) 
               
               
                 Aqueous Flow (mL/min) 
                 8 
                 8 
                 8 
                 8 
               
               
                 Organic flow (mL/min) 
                 32 
                 32 
                 32 
                 32 
               
               
                 Secondary drying gas flow 
                 0 
                 0 
                 0 
                 0 
               
               
                 (kg/hr) 
               
               
                 Secondary drying gas 
                 0 
                 0 
                 0 
                 0 
               
               
                 temperature (° C.) 
               
               
                 Product filter purge gas flow 
                 15 
                 15 
                 15 
                 15 
               
               
                 (scfh) 
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6- 
                 67-6- 
                 67-6- 
                 67-6- 
               
               
                   
                 20-150 
                 20-150 
                 20-150 
                 20-150 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                 TABLE 39 
               
               
                   
                   
               
             
            
               
                   
                 Total solid concentration (g/L) 
                 4 
               
               
                   
                 Inlet Temperature (° C.) 
                 79 
               
               
                   
                 Outlet Temperature (° C.) 
                 44 
               
               
                   
                 Drying Gas Rate (kg/hr) 
                 100 
               
               
                   
                 Atomization Gas Flow Rate (g/min) 
                 22 
               
               
                   
                 Aqueous Flow (mL/min) 
                 8 
               
               
                   
                 Organic flow (mL/min) 
                 32 
               
               
                   
                 Secondary drying gas flow (kg/hr) 
                 0 
               
               
                   
                 Secondary drying gas temperature 
                 0 
               
               
                   
                 (° C.) 
               
               
                   
                 Product filter purge gas flow (scfh) 
                 15 
               
               
                   
                 Aqueous phase 
                 Water 
               
               
                   
                 Organic phase 
                 Ethanol 
               
               
                   
                 Aircap 
                 67-6-20-150 
               
               
                   
                 Fluid cap 
                 2850 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                 TABLE 40 
               
               
                   
                   
               
             
            
               
                   
                 Total solid concentration (g/L) 
                 4 
               
               
                   
                 Inlet Temperature (° C.) 
                 79 
               
               
                   
                 Outlet Temperature (° C.) 
                 44 
               
               
                   
                 Drying Gas Rate (kg/hr) 
                 100 
               
               
                   
                 Atomization Gas Flow Rate (g/min) 
                 22 
               
               
                   
                 Aqueous Flow (mL/min) 
                 8 
               
               
                   
                 Organic flow (mL/min) 
                 32 
               
               
                   
                 Secondary drying gas flow (kg/hr) 
                 0 
               
               
                   
                 Secondary drying gas temperature (° C.) 
                 0 
               
               
                   
                 Product filter purge gas flow (scfh) 
                 15 
               
               
                   
                 Aqueous phase 
                 Water 
               
               
                   
                 Organic phase 
                 Ethanol 
               
               
                   
                 Aircap 
                 67-6-20-150 
               
               
                   
                 Fluid cap 
                 2850 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 41 
               
               
                   
               
               
                 Lot Number 
                 155043 
                 155044 
                 155041 
                 155042 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Total solid concentration (g/L) 
                 4 
                 4 
                 4 
                 4 
               
               
                 Inlet Temperature (° C.) 
                 87 
                 87 
                 87 
                 87 
               
               
                 Outlet Temperature (° C.) 
                 50 
                 50 
                 50 
                 50 
               
               
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
                 100 
               
               
                 Atomization Gas Flow Rate 
                 33 
                 33 
                 33 
                 33 
               
               
                 (g/min) 
               
               
                 Aqueous Flow (mL/min) 
                 8 
                 8 
                 8 
                 8 
               
               
                 Organic flow (mL/min) 
                 32 
                 32 
                 32 
                 32 
               
               
                 Secondary drying gas flow (kg/hr) 
                 0 
                 0 
                 0 
                 0 
               
               
                 Secondary drying gas temperature 
                 0 
                 0 
                 0 
                 0 
               
               
                 (° C.) 
               
               
                 Product filter purge gas flow 
                 15 
                 15 
                 15 
                 15 
               
               
                 (scfh) 
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6- 
                 67-6- 
                 67-6- 
                 67-6- 
               
               
                   
                 20-150 
                 20-150 
                 20-150 
                 20-150 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE 42 
               
               
                   
               
               
                 Lot Number 
                 155059 
                 155060 
                 155061 
                 155062 
                 155063 
                 155064 
                 155065 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Total solid 
                 4 
                 4 
                 4 
                 4 
                 4 
                 4 
                 4 
               
               
                 concentration (g/L) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Inlet Temperature 
                 120 
                 120 
                 120 
                 120 
                 120 
                 120 
                 120 
               
               
                 (° C.) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Outlet Temperature 
                 60 
                 60 
                 60 
                 60 
                 60 
                 60 
                 60 
               
               
                 (° C.) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Drying Gas 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 Rate (kg/hr) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Atomization Gas  
                 44 
                 44 
                 44 
                 44 
                 44 
                 44 
                 44 
               
               
                 Flow Rate (g/min) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Aqueous Flow 
                 12 
                 12 
                 12 
                 12 
                 12 
                 12 
                 12 
               
               
                 (mL/min) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Organic flow 
                 48 
                 48 
                 48 
                 48 
                 48 
                 48 
                 48 
               
               
                 (mL/min) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Secondary drying  
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 gas flow (kg/hr) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Secondary drying  
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 gas temperature 
                   
                   
                   
                   
                   
                   
                   
               
               
                 (° C.) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Product filter purge  
                 15 
                 15 
                 15 
                 15 
                 15 
                 15 
                 15 
               
               
                 gas flow (scfh) 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
                 2850 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 43 
               
               
                   
               
               
                 Lot Number 
                 155091 
                 155092 
                 155094 
                 155095 
                 155097 
                 155098 
                 155100-1 
                 155100-2 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 Total solid concentration 
                 4 
                 4 
                 4 
                 4 
                 4 
                 4 
                 4 
                 4 
               
               
                 (g/L) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Inlet Temperature (° C.) 
                 79 
                 79 
                 79 
                 79 
                 79 
                 79 
                 79 
                 79 
               
               
                 Outlet Temperature (° C.) 
                 44 
                 44 
                 44 
                 44 
                 44 
                 44 
                 44 
                 44 
               
               
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 Atomization Gas Flow 
                 33 
                 33 
                 33 
                 33 
                 33 
                 33 
                 33 
                 33 
               
               
                 Rate (g/min) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Aqueous Flow (mL/min) 
                 8 
                 8 
                 8 
                 8 
                 8 
                 8 
                 8 
                 8 
               
               
                 Organic flow (mL/min) 
                 32 
                 32 
                 32 
                 32 
                 32 
                 32 
                 32 
                 32 
               
               
                 Secondary drying gas flow 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 (kg/hr) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Secondary drying gas 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 temperature (° C.) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Product filter purge gas 
                 15 
                 15 
                 15 
                 15 
                 15 
                 15 
                 15 
                 15 
               
               
                 flow (scfh) 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
                 2850 
                 2850 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE 44 
               
               
                   
               
             
            
               
                 Lot Number 
                 155104 
                 155105 
                 155106 
                 155107 
                 155108 
                 155109 
               
               
                   
               
               
                 Total solid 
                 4 
                 4 
                 4 
                 4 
                 4 
                 4 
               
               
                 concentration  
                   
                   
                   
                   
                   
                   
               
               
                 (g/L) 
                   
                   
                   
                   
                   
                   
               
               
                 Inlet 
                 103 
                 103 
                 103 
                 103 
                 103 
                 103 
               
               
                 Temperature 
                   
                   
                   
                   
                   
                   
               
               
                 (° C.) 
                   
                   
                   
                   
                   
                   
               
               
                 Outlet 
                 60 
                 60 
                 60 
                 60 
                 60 
                 60 
               
               
                 Temperature 
                   
                   
                   
                   
                   
                   
               
               
                 (° C.) 
                   
                   
                   
                   
                   
                   
               
               
                 Drying Gas 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 Rate (kg/hr) 
                   
                   
                   
                   
                   
                   
               
               
                 Atomization 
                 33 
                 33 
                 33 
                 33 
                 33 
                 33 
               
               
                 Gas Flow 
                   
                   
                   
                   
                   
                   
               
               
                 Rate (g/min) 
                   
                   
                   
                   
                   
                   
               
               
                 Aqueous 
                 8 
                 8 
                 8 
                 8 
                 8 
                 8 
               
               
                 Flow 
                   
                   
                   
                   
                   
                   
               
               
                 (mL/min) 
                   
                   
                   
                   
                   
                   
               
               
                 Organic flow 
                 32 
                 32 
                 32 
                 32 
                 32 
                 32 
               
               
                 (mL/min) 
                   
                   
                   
                   
                   
                   
               
               
                 Secondary 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 drying gas 
                   
                   
                   
                   
                   
                   
               
               
                 flow (kg/hr) 
                   
                   
                   
                   
                   
                   
               
               
                 Secondary 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 drying gas 
                   
                   
                   
                   
                   
                   
               
               
                 temperature 
                   
                   
                   
                   
                   
                   
               
               
                 (° C.) 
                   
                   
                   
                   
                   
                   
               
               
                 Product filter 
                 15 
                 15 
                 15 
                 15 
                 15 
                 15 
               
               
                 purge gas 
                   
                   
                   
                   
                   
                   
               
               
                 flow (scfh) 
                   
                   
                   
                   
                   
                   
               
               
                 Aqueous 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 phase 
                   
                   
                   
                   
                   
                   
               
               
                 Organic 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
            
           
           
               
               
               
               
               
               
            
               
                 phase 
                   
                   
                   
                   
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Lot Number 
                 155110 
                 155111 
                 155112 
                 155113 
                 155114 
                 155115 
               
               
                   
               
               
                 Total solid 
                 4 
                 4 
                 4 
                 4 
                 4 
                 4 
               
               
                 concentration  
                   
                   
                   
                   
                   
                   
               
               
                 (g/L) 
                   
                   
                   
                   
                   
                   
               
               
                 Inlet 
                 103 
                 103 
                 103 
                 103 
                 117 
                 125 
               
               
                 Temperature 
                   
                   
                   
                   
                   
                   
               
               
                 (° C.) 
                   
                   
                   
                   
                   
                   
               
               
                 Outlet 
                 60 
                 60 
                 60 
                 60 
                 60 
                 60 
               
               
                 Temperature 
                   
                   
                   
                   
                   
                   
               
               
                 (° C.) 
                   
                   
                   
                   
                   
                   
               
               
                 Drying Gas 
                 100 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 Rate (kg/hr) 
                   
                   
                   
                   
                   
                   
               
               
                 Atomization 
                 33 
                 33 
                 33 
                 33 
                 33 
                 33 
               
               
                 Gas Flow 
                   
                   
                   
                   
                   
                   
               
               
                 Rate (g/min) 
                   
                   
                   
                   
                   
                   
               
               
                 Aqueous 
                 8 
                 8 
                 8 
                 8 
                 12 
                 16 
               
               
                 Flow 
                   
                   
                   
                   
                   
                   
               
               
                 (mL/min) 
                   
                   
                   
                   
                   
                   
               
               
                 Organic flow 
                 32 
                 32 
                 32 
                 32 
                 48 
                 64 
               
               
                 (mL/min) 
                   
                   
                   
                   
                   
                   
               
               
                 Secondary 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 drying gas 
                   
                   
                   
                   
                   
                   
               
               
                 flow (kg/hr) 
                   
                   
                   
                   
                   
                   
               
               
                 Secondary 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 drying gas 
                   
                   
                   
                   
                   
                   
               
               
                 temperature 
                   
                   
                   
                   
                   
                   
               
               
                 (° C.) 
                   
                   
                   
                   
                   
                   
               
               
                 Product filter 
                 15 
                 15 
                 15 
                 15 
                 15 
                 15 
               
               
                 purge gas 
                   
                   
                   
                   
                   
                   
               
               
                 flow (scfh) 
                   
                   
                   
                   
                   
                   
               
               
                 Aqueous 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 phase 
                   
                   
                   
                   
                   
                   
               
               
                 Organic 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 phase 
                   
                   
                   
                   
                   
                   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 45 
               
               
                   
               
             
            
               
                 Lot Number 
                 155125 
                 155126 
                 155127 
                 155128 
                 155129 
               
               
                   
               
               
                 Total solid concentration 
                 4 
                 4 
                 4 
                 4 
                 4 
               
               
                 (g/L) 
               
               
                 Inlet Temperature (° C.) 
                 103 
                 103 
                 103 
                 103 
                 103 
               
               
                 Outlet Temperature (° C.) 
                 60 
                 60 
                 60 
                 60 
                 60 
               
               
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 Atomization Gas Flow Rate 
                 33 
                 33 
                 33 
                 33 
                 33 
               
               
                 (g/min) 
               
               
                 Aqueous Flow (mL/min) 
                 8 
                 8 
                 8 
                 8 
                 8 
               
               
                 Organic flow (mL/min) 
                 32 
                 32 
                 32 
                 32 
                 32 
               
               
                 Secondary drying gas flow 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 (kg/hr) 
               
               
                 Secondary drying gas 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 temperature (° C.) 
               
               
                 Product filter purge gas flow 
                 15 
                 15 
                 15 
                 15 
                 15 
               
               
                 (scfh) 
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Lot Number 
                 155130 
                 155131 
                 155132 
                 155133 
                 155134 
               
               
                   
               
               
                 Total solid 
                 4 
                 4 
                 4 
                 4 
                 4 
               
               
                 concentration (g/L) 
               
               
                 Inlet Temperature (° C.) 
                 103 
                 103 
                 103 
                 103 
                 103 
               
               
                 Outlet Temperature 
                 60 
                 60 
                 60 
                 60 
                 60 
               
               
                 (° C.) 
               
               
                 Drying Gas Rate 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 (kg/hr) 
               
               
                 Atomization Gas Flow 
                 33 
                 33 
                 33 
                 33 
                 33 
               
               
                 Rate (g/min) 
               
               
                 Aqueous Flow 
                 8 
                 8 
                 8 
                 8 
                 8 
               
               
                 (mL/min) 
               
               
                 Organic flow (mL/min) 
                 32 
                 32 
                 32 
                 32 
                 32 
               
               
                 Secondary drying gas 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 flow (kg/hr) 
               
               
                 Secondary drying gas 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 temperature (° C.) 
               
               
                 Product filter purge gas 
                 15 
                 15 
                 15 
                 15 
                 15 
               
               
                 flow (scfh) 
               
               
                 Aqueous phase 
                 Water 
                 Water 
                 Water 
                 Water 
                 Water 
               
               
                 Organic phase 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
                 Ethanol 
               
               
                 Aircap 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
                 67-6-20-150 
               
               
                 Fluid cap 
                 2850 
                 2850 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 46 
               
               
                   
                   
               
               
                   
                 189065- 
                 189065- 
                 189065- 
               
               
                   
                 1 
                 2 
                 3 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Param- 
                 Total solid concentration (g/L) 
                 4 
                 4 
                 4 
               
               
                 eters 
                 Inlet Temperature (° C.) 
                 78 
                 87 
                 103 
               
               
                   
                 Outlet Temperature (° C.) 
                 40 
                 50 
                 60 
               
               
                   
                 Drying Gas Rate (kg/hr) 
                 100 
                 100 
                 100 
               
               
                   
                 Atomization Gas Flow Rate 
                 22 
                 22 
                 22 
               
               
                   
                 (g/min) 
               
               
                   
                 Aqueous Flow (mL/min) 
                 8 
                 8 
                 8 
               
               
                   
                 Organic flow (mL/min) 
                 32 
                 32 
                 32 
               
               
                   
                 Secondary drying gas 
                 0 
                 0 
                 0 
               
               
                   
                 flow (kg/hr) 
               
               
                   
                 Secondary drying gas 
                 0 
                 0 
                 0 
               
               
                   
                 temperature (° C.) 
               
               
                   
                 Product filter purge 
                 15 
                 15 
                 15 
               
               
                   
                 gas flow (scfh) 
               
               
                 Atom- 
                 Air cap 
                 67-6- 
                 67-6- 
                 67-6-20- 
               
               
                 ization 
                   
                 20-150 
                 20-150 
                 150 
               
               
                 nozzle 
                 Fluid cap 
                 2850 
                 2850 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                   
                 TABLE 47 
               
               
                   
                   
               
               
                   
                 Value 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 Parameters 
                 Total solid concentration (g/L) 
                 4 
               
               
                   
                 Inlet Temperature (° C.) 
                 103 
               
               
                   
                 Outlet Temperature (° C.) 
                 60 
               
               
                   
                 Drying Gas Rate (kg/hr) 
                 100 
               
               
                   
                 Atomization Gas Flow Rate (g/min) 
                 22 
               
               
                   
                 Aqueous Flow (mL/min) 
                 8 
               
               
                   
                 Organic flow (mL/min) 
                 32 
               
               
                   
                 Secondary drying gas flow (kg/hr) 
                 0 
               
               
                   
                 Secondary drying gas temperature (° C.) 
                 0 
               
               
                   
                 Product filter purge gas flow (scfh) 
                 15 
               
               
                 Atomization 
                 Air cap 
                 67-6-20-150 
               
               
                 nozzle 
                 Fluid cap 
                 2850 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                   
                 TABLE 48 
               
               
                   
                   
               
               
                   
                 Value 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 Parameters 
                 Total solid concentration (g/L) 
                 4 
               
               
                   
                 Inlet Temperature (° C.) 
                 103 
               
               
                   
                 Outlet Temperature (° C.) 
                 60 
               
               
                   
                 Drying Gas Rate (kg/hr) 
                 100 
               
               
                   
                 Atomization Gas Flow Rate (g/min) 
                 22 
               
               
                   
                 Aqueous Flow (mL/min) 
                 16 
               
               
                   
                 Organic flow (mL/min) 
                 24 
               
               
                   
                 Secondary drying gas flow (kg/hr) 
                 0 
               
               
                   
                 Secondary drying gas temperature (° C.) 
                 0 
               
               
                   
                 Product filter purge gas flow (scfh) 
                 15 
               
               
                 Atomization 
                 Air cap 
                 67147 
               
               
                 nozzle 
                 Fluid cap 
                 2850 
               
               
                   
               
            
           
         
       
     
     While this invention has been particularly shown and described with references to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention encompassed by the appended claims. It should also be understood that the embodiments described herein are not mutually exclusive and that features from the various embodiments may be combined in whole or in part in accordance with the invention.