Patent Publication Number: US-11655440-B2

Title: Methods and devices for aseptic dry transfer

Description:
CROSS REFERENCE TO RELATED APPLICATION 
     This is a national stage application under 35 U.S.C. § 371 of International Application No. PCT/US2018/062470 filed on Nov. 26, 2018, which claims the benefit of priority under 35 U.S.C § 120 of U.S. Provisional Application Ser. No. 62/592,709 filed on Nov. 30, 2017, the contents of which are relied upon and incorporated herein by reference in their entirety. 
    
    
     BACKGROUND 
     The following relates generally to product transfer, and more specifically to transferring dry product in an aseptic system. 
     Products, such as dry powders, may be difficult to transfer out of a container based on the properties of the container. For example, dry powders may not completely transfer out of a system due to product hang up. Powders may get hung up on rough or flat surfaces, which leads to a loss of usable product. Dry powders, such as dissolvable microcarriers, may be transported in a sealed container to prevent contamination from the environment. In many cases, cell growth or regulatory standards may require a closed, aseptic, or sterile environment. 
     The deployment of dissolvable microcarriers in adherent cell cultures allows more surface area per unit volume for cell growth than two dimensional surfaces. Traditionally, cell growth within bioreactors was limited by the surface area available on traditional two-dimensional adherent surfaces. Microcarriers may have the ability to easily scale up cell growth within bioreactors. Dry microcarriers may have a substantially spherical shape with a diameter of about 30 microns. Once hydrated, microcarriers may have a diameter of about 250 microns. 
     Complete product transfer may be significant for the cost and yields desired by a consumer. Product that remains in the container may be unusable and can result in the loss of money and a lower process yield. To enable increased product transfer in systems such as aseptic cell cultures with microcarriers, an aseptic transfer device may be needed to introduce product (e.g., the microcarriers) into the system (e.g., culture vessel). 
     SUMMARY 
     The present disclosure is directed towards a device and systems for product delivery. In some embodiments, the product delivery device can include an inlet port, a conical section including a wide end and a narrow end, an outlet port flush with the narrow end of the conical section and extending away from the conical section, and a securement feature configured to connect the wide end of the conical section to a container. 
     In some embodiments, the diameter of the narrow end is smaller than the diameter of the wide end. In some embodiments, walls of the conical section extend from the wide end to the narrow end and can define an angle of the conical section. In some cases, the angle of the conical section can vary along a circumference of the narrow end, the wide end, or both. In other cases, the angle of the conical section can be uniform along a circumference of the narrow end, the wide end, or both. 
     In some embodiments, the device or system can further include a single piece cap that can include the inlet port, the conical section, the outlet port, and the securement feature. According to various aspects of the disclosure, the securement feature can be configured to form a wedge fit with the container. In some cases, the cap can be formed by injection molding. 
     In some embodiments, the device or system can further include a two-piece cap that can include the inlet port, the conical section, the outlet port, and the securement feature. According to various aspects of the disclosure, the device or system can also include a first piece comprising a stopper, and a second piece comprising the securement feature, wherein the first piece can engage with the second piece to create a seal when connected to the container. 
     In some embodiments, the device or system can further include a three or more-piece cap including the inlet port, the conical section, the outlet port, and the securement feature. According to various aspects of the disclosure, the device or system can also include a first piece including the conical section and the outlet port, a second piece including the securement feature, and a third piece including a gasket, wherein the first piece engages with the second piece to deform the gasket when connected to the container. 
     In some embodiments, the gasket can include an internal angle based at least in part on an angle of the conical section. In some embodiments, the securement feature includes threads configured to engage an internal surface of the container. 
     In some embodiments, the product delivery device can include at least one of polyethylene, polypropylene, polystyrene, polycarbonate, or silicon. In some embodiments, the inlet port and outlet port include an external barb. 
     A system for product delivery can include a container at least partially filled with the product, and a product delivery device including a conical section with a wide end and a narrow end, and an outlet port flush with the narrow end of the conical section, wherein the product is transferred from the conical section through the outlet port. 
     In some embodiments, the device or system can further include an inlet port, and a securement feature configured to connect the wide end of the conical section to the container. According to various aspects of the disclosure, the device or system can also include a dip tube connected to the inlet port and extending to an opposite side of the container that the inlet port. 
     In some embodiments, the device or system can further include a gasket between the product delivery device and the container, the gasket configured to deform to create a hermetic seal. In some embodiments, the device or system can be aseptic. 
     In some embodiments, the product is a dry free flowing powder. In some cases, the product is dissolvable microcarriers. 
     Another system for product delivery can include a container at least partially filled with the aseptic dry product, a product delivery device including a conical section with a wide end and a narrow end, and an outlet port flush with the narrow end of the conical section. According to his system, the dry product is transferred from the conical section through the outlet port, a pressure source connected to an inlet port, and a receiving vessel, where the aseptic dry product is collected. 
     In some embodiments, the device or system can further include a gasket between the product delivery device and the container, the gasket being configured to deform to create a hermetic seal. In some embodiments, the device or system can be closed to the environment. In some embodiments, the device or system can be aseptic or sterile. 
     In some embodiments, the device or system can further include a dip tube connected to the inlet port that extends into the container. The dip tube can be configured to transfer pressure from the pressure source into the container. 
     In some embodiments, the product is a dry, free-flowing powder. In some cases, the product includes dissolvable microcarriers. In some examples, the dry product can be hydrated in the receiving vessel. In some embodiments, the inlet port and outlet port include an external barb. 
     In some embodiments, the device or system can further include a first tube connected to the inlet port, a first clamp configured to pinch the first tube, a second tube connected to the outlet port, and a second clamp configured to pinch the second tube. 
     One or more representative embodiments is provided to illustrate the various features, characteristics, and advantages of the disclosed subject matter. The embodiments are provided in the context of glass electrochemical sensors. It should be understood, however, that many of the concepts can be used in a variety of other settings, situations, and configurations. For example, the features, characteristics, advantages, etc., of one embodiment can be used alone or in various combinations and sub-combinations with one another. 
     The Summary is provided to introduce a selection of concepts in a simplified form that are further described below in the Detailed Description. The Summary and the Background are not intended to identify key concepts or essential aspects of the disclosed subject matter, nor should they be used to constrict or limit the scope of the claims. For example, the scope of the claims should not be limited based on whether the recited subject matter includes any or all aspects noted in the Summary and/or addresses any of the issues noted in the Background. 
    
    
     
       BRIEF DESCRIPTION OF DRAWINGS 
       The preferred and other embodiments are disclosed in association with the accompanying drawings in which: 
         FIG.  1    illustrates a cross-sectional view of an example of a closed system for product transfer in accordance with various aspects of the present disclosure. 
         FIG.  2    illustrates a cross-sectional view of an example of a product delivery system in accordance with various aspects of the present disclosure. 
         FIG.  3    illustrates a cross-sectional view of an example of a product delivery device in accordance with various aspects of the present disclosure. 
         FIG.  4    illustrates a cross-sectional view of an example of an alternative product delivery system in accordance with various aspects of the present disclosure. 
         FIG.  5    illustrates a cross-sectional view of an example of a single piece product delivery system in accordance with various aspects of the present disclosure. 
         FIG.  6    illustrates a cross-sectional view of an example of a two-piece product delivery system in accordance with various aspects of the present disclosure. 
         FIG.  7    illustrates a cross-sectional view of an example of a three-piece product delivery system in accordance with various aspects of the present disclosure. 
     
    
    
     DETAILED DESCRIPTION 
     The present disclosure relates to devices and systems for delivering materials (e.g., dry products) wherein the devices and systems enable as complete of a transfer as possible, including, but in no way limited to, the aseptic transfer of dissolvable microcarriers (DMCs). An easy to use container can enable the optimal delivery of product while minimizing the product lost, which can be hung up in the container (e.g., the lid and outlet port of the container). Such a device can be valuable for systems that require specific environmental standards, such as a clean room, to avoid contamination. The transfer can enable the system to remain closed to the outside environment, allowing reduced requirements for the external environment of the system. In some cases, product that is sterile or aseptic could remain sterile or aseptic using the devices and systems described herein. The devices and systems described can also be designed to withstand abnormal pressure (e.g., above or below atmospheric pressure). A pressure gradient in combination with the described devices and systems can allow a more complete delivery of product. In some cases, the product to be delivered by this device can be dry or wet, and the product can be a fluid or a solid. 
     Conventional systems for delivering materials (e.g., dry products) can be unable to minimize the residual material in a container due to the geometry of such devices. The present disclosure relates to a product delivery system that enables improved product transfer by reducing resistance of the path for a product to exit the container in the system, which allows for minimized product hang up. This disclosure lends itself to the transfer of DMCs in a closed system, thus enabling the process of adherent cell growth in a bioreactor. In particular, this system can include a container at least partially filled with product (e.g., aseptic dry DMCs), and a cap device that connects to the container. In some examples, this process also allows for the use of back pressure to force more product out of the container and allows for a more rapid flow out of the container, relative to the use of gravity alone, and through any associated tubing. The product can leave the container through an outlet port that is flush with a narrow end of a conical section. The outlet port may not extend into the conical section, which reduces the resistance of the path for a product to exit the container. Although this disclosure can be described in relation to the transfer of DMCs, the devices and systems can be applied to the transfer of a variety of materials. 
       FIG.  1    illustrates a cross-sectional view of an example of a closed system  100  for product transfer in accordance with various aspects of the present disclosure. As illustrated in  FIG.  1   , the system  100  can include a container  105 , a product delivery device  110 , a pressure source  120 , and a receiving vessel  125 . 
     The container  105  can be at least partially filled with a product  115  (e.g., a free-flowing powder such as dry DMCs). The container  105 , as shown in  FIG.  1   , is inverted. Before the container  105  is inverted, a dip tube can be inserted in the inlet port, the product delivery device  110  (e.g., a cap) can be secured onto the container  105 , and the tubing  130  and  135  can be connected to the inlet port and outlet port, respectively. The container  105  can be secured in an inverted position by a clamp or other commonly known configurations for positioning a device. 
     The product delivery device  110  can be secured onto the container  105  (e.g., screwing onto internal or external threads on the container), formed as an integral part of the container  105  by any number of manufacturing methods, including, but in no way limited to,  3 D printing, blow molding, and the like. The product delivery device  110  can have a conical internal shape, where internal is defined herein as being disposed between the walls of the device  110 . The conical section of the product delivery device  110  can allow for optimized transfer of product  115  to the receiving vessel  125  by reducing residual product in the container  105 . 
     The pressure source  120  can be connected to the inlet of the product delivery device  110  by tubing  130 , which can include a vent  140  and vent filter to catch or otherwise prevent contaminates from entering the container  105 . Alternatively, the vent  140  can be attached to the container  105 , rather than the tubing  130 . In any event, the tubing  130  and vent  140  form a fluid flow path between the pressure source  120  and the inlet of the container  105 . The pressure source  120  can provide pressure through the tubing  130  to the dip tube in the container  105  in order to provide pressure at the top of the container  105 . As illustrated in  FIG.  1   , the top of the container  105  is shown with no product  115 . Consequently, the addition of pressure to the container  105  can apply a force on the product  115  to move to a lower pressure area (e.g., the receiving vessel  125 ). Thus, the product  115  will travel out of the container  105  and have minimal, if any, product hang up in the container  105  due to the shape of the conical section and the placement of the outlet port. 
     Receiving vessel  125  can be connected to the outlet of the product delivery device  110  by tubing  135 . In some examples, the receiving vessel  125  can be a bioreactor where the product  115  transferred from the container  105  can aid in cell growth. If the product  115  were DMCs, then the DMCs can be hydrated within the receiving vessel  125 . 
     The entire system  100  can be closed and be configured to maintain an aseptic or sterile environment. The size of the container  105 , product delivery device  110 , and other aspects of the system  100  can be a variety of sizes, based on the amount of the product  115 . 
       FIG.  2    illustrates a cross-sectional view of an example of a product delivery system  200  in accordance with various aspects of the present disclosure. As illustrated in  FIG.  2   , the system  200  can include a container  205 , a product delivery device  210 , product  215 , an inlet port  220 , and an outlet port  225 . The container  205  can be an example of container  105  as shown in  FIG.  1   . Product delivery device  210  can be an example of product delivery device  110 . 
     The inlet port  220  of the product delivery device  210  can be connected to a dip tube  240  that extends from the inlet port  220  to the opposite side of the container  205  (e.g., the top of the container  205 ). A pressure source ( 120  from  FIG.  1   ) can be connected to the inlet port  220  outside of the container  205  and can provide pressure through the dip tube  240  into the container  205  in order to provide pressure at the top of the container  205  where the top of the container  205  is shown with no product  215 . The addition of pressure to the container  205  can apply a force on the product  215  to move to a lower pressure area. Thus, the product  215  will travel out of the container  205  and have minimal if any product hang up in the container  205  due to the shape of the conical section and the placement of the outlet port  225 . 
     In some cases, the tubing that is fluidly connected to the inlet port  220  can include a clamp  230 . The clamp  230  can temporarily engage the tubing (e.g., tubing  130  in  FIG.  1   ) to create a pinch in the tubing to prevent product  215  from flowing further into the tubing. Another clamp  235  can be placed on tubing that is fluidly connected to the outlet port  225 . Clamp  235  can be similar to clamp  230 , and clamp  235  can temporarily engage the tubing (e.g., tubing  135  in  FIG.  1   ) to create a pinch in the tubing to prevent product  215  from flowing further into the tubing. Once the system is ready for operation, the clamps  230  and  235  can be disengaged to allow product, pressurized air, or other elements to flow through the tubing. For example, the clamps  230  and  235  can be disengaged after tubing on the far side of the clamp, the side opposite the outlet port  225 , is welded to other tubing in the system and evacuated of any undesirable elements. These clamps  230  and  235  can allow for cleaner tube welds and for maintaining the seal of the system  200  from the external environment. Thus, the system  200  can remain closed. 
     According to various aspects of this disclosure, the outlet port  225  can be arranged on the product delivery device  210  such that the uppermost portion of the outlet port  225  is flush with the interior conical section of the container  205 . For example, the edge between the conical section and the outlet port  225  can be continuous and smooth such that there is reduced resistance for a product  215  to exit the container  205  through the outlet port  225 . 
       FIG.  3    illustrates a cross-sectional view of an example of a product delivery device  300 , in accordance with various aspects of the present disclosure. As illustrated in  FIG.  3   , the product delivery device  300  can include an inlet port  310 , an outlet port  315 , and a conical section  320 . 
     Inlet port  310  can be arranged anywhere on the device  300  apart from and physically separated from the outlet port  315 . In some examples, the inlet port  310  can be connected to the conical section  320  at a distance from the outlet port  315 . As illustrated in  FIG.  3   , the inlet port  310  can be flush with the conical section  320 . In other cases, the inlet port  310  can extend into the conical section  320  and can include a dip tube disposed therein. 
     The outlet port  315  can be attached to the narrow end  330  of the conical section. The outlet port  315  can be flush with the conical section  320  (e.g., a continuous surface with a corner). The outlet port  315  can be positioned anywhere on the device  300  provided that the outlet port  315  is flush with the narrow end of the conical section. 
     Conical section  320  can also include a wide end  325  and a narrow end  330 . The narrow end  330  can have a diameter that is smaller than the diameter of the wide end  325 . Dotted lines  335  and  345  are shown to clarify the angles of the conical section  320  walls. Angles  340  and  350  are depicted between the plane of the wide end  325  and dotted lines  345  and  355 , respectively. Angles  340  and  350  can be different or the same. If the angles  340  and  350  are different, the angles around the entire conical section can vary along the circumference of the wide end  325 , the narrow end  330 , or both. If the angles  340  and  350  are the same, the angles around the entire conical section can be uniform along the circumference of the wide end  325  and the narrow end  330 . Angles  340  and  350  can be greater than 0 degrees, for example greater than 25 degrees. 
       FIG.  4    illustrates a cross-sectional view of an example of an alternative product delivery system  400  in accordance with various aspects of the present disclosure. As illustrated in  FIG.  4   , system  400  can include a container  405 , inlet port  410 , and outlet port  420 . This system  400  can be implemented in system  100 . 
     Container  405  can be at least partially filled with product  415 . In some cases, container  405  can have a conical shape as illustrated in  FIG.  4   . 
     Inlet port  410  can be secured to the top of the container  405 . In some examples, inlet port  410  can allow pressure to be transferred into the container  405  to apply a pressure to the product  415 . The pressure can force the product  415  out of the container  405  through the outlet port  420 . 
     Outlet port  420  can be connected to the conical section of the container  405 . The outlet port  420  can be flush with the narrow end of the conical section of the container  405 . 
       FIG.  5    illustrates a cross-sectional view of an example of a single piece product delivery system  500 , in accordance with various aspects of the present disclosure. As illustrated in  FIG.  5   , system  500  can include a container  505  and a product delivery device  510 . 
     Product delivery device  510  can be a single piece of material that includes securement features  515 , a conical section  520 , an outlet port  535 , and an inlet port  540 . Product delivery device  510  can be formed by any number of manufacturing methodologies including, but in no way limited to, injection molding. In some examples, the product delivery device  510  can be manufactured of any suitable material, including, but in no way limited to, at least one of polyethylene, polypropylene, polystyrene, polycarbonate, or silicone. 
     Securement features  515 - a  and  515 - b  can attach the wide end  525  of the conical section  520  to the container  505 . In some cases, securement feature  515 - a  can engage with threads of the container  505 . As shown, the securement features  515 - a  of the container  505  are illustrated as external threads formed as circumferential protrusions on the lower outer surface of the container  505  adjacent to the bottommost opening in the container, where they can be rotationally engaged with internal threads formed on the inner circumferential surface of the product delivery device. However, in some cases, the securement feature  515 - a  can engage with internal threads of the container  505 . Securement feature  515 - b  can form a wedge or interference fit with the inside or top of the container mouth. The securement features  515 - b  can have an internal angle similar in geometry to the conical section  520  to allow smooth flow of product. The securement features  515 - a  and  515 - b  allow for an improved seal between the product delivery device  510  and the container  505 . In some cases, the seal can allow the system  500  to be closed. 
     Conical section  520  can include a wide end  525  and a narrow end  530 . An outlet port  535  can be flush with the narrow end  530 . As illustrated, outlet port  535  and inlet port  540  can include one or more external barbs  545  and  550 , respectively. Barbs  545  and  550  allow for tubing to securely connect to each port. In some cases, the barbs  545  and  550  allow tubing to remain connected to the ports when the system is pressurized. 
       FIG.  6    illustrates a cross-sectional view of an example of a two-piece product delivery system  600  in accordance with various aspects of the present disclosure. As illustrated in  FIG.  6   , system  600  can include a container  605  and a two-piece product delivery device  610 . 
     Product delivery device  610  can be two separate component pieces, combined to form the delivery device  610 . The first piece can include a collar piece  613  including a distal lip  614 , having the securement features  615  formed on an inner surface of the collar piece  613 , as illustrated in  FIG.  6   . The second piece of the product delivery device  610  can include the conical section  620 , a stopper  625  including a seating lip  627  that engages the distal lip  614  of the collar piece  613 , an inlet port  635 , and an outlet port  640 . In some examples, the product delivery device  610  can be formed of at least one or more of polyethylene, polypropylene, polystyrene, polycarbonate, or silicone. 
     Securement features  615  can attach the wide end of the conical section  620  to the container  605 . In some cases, securement feature  615  can engage with threads of the container  605 . As shown, the threads are formed as protrusions circumferentially formed on the external wall of the bottommost opening of the container  605 , however, in some cases, the securement feature  615  can engage with internal threads of the container  605 . When the securement features  615  of the first piece, such as the collar  613 , engage with the threads of the container  605 , the second piece can be positioned between the first piece and the container&#39;s mouth such that the edges of the stopper  625  are secured. More specifically, according to one embodiment, the seating lip  627  of the stopper  625  engages the distal lip  614  of the collar piece  613 , and is compressed between the distal lip  614  of the collar piece and the end of the container  605  as it is advanced along the securement features. This configuration allows for a compressed seal between the product delivery device  610  and the container  605 . In some cases, the seal can allow the system  600  to be closed. 
     Conical section  620  can include a wide end  621  and a narrow end  622 , which can be hollowed out of the stopper  625 . Stopper  625  can be made of a flexible material (e.g., silicone), and the collar piece  613  can be made of a rigid material (e.g., polyethylene). The angle of the conical section  620  can be the same or differ along the circumference of the wide end  621 , the narrow end  622 , or both. If the angles are the same around the entire conical section, they can be uniform along the circumference of the wide end and the narrow end, as shown. In some cases, the angles can be greater than 0 degrees, for example greater than 25 degrees. 
     An outlet port  640  can be flush with the narrow end of the conical section  620 . As illustrated, inlet port  635  and outlet port  640  can extend away from the container  605 . The outlet port  640  can be centered within the stopper  625 . Although not shown, the inlet port  635  and outlet port  640  can include external barbs. 
       FIG.  7    illustrates a cross-sectional view of an example of a three-piece product delivery system  700  in accordance with various aspects of the present disclosure. As illustrated in  FIG.  7   , the system  700  can include a container  705  and a three-piece product delivery device  710 . 
     The three-piece product delivery device  710  can be formed of three separate and distinct pieces, which can be manufactured of the same or different types of material. The first piece of the three-piece product delivery device  710  can include a collar piece  713  including a distal lip  714 , and a securement feature  715  formed on an inner surface thereof, as illustrated in  FIG.  7   . The second piece of the three-piece product delivery device  710  can include conical section  720 , an outlet port  735 , and an inlet port  740 . As illustrated in  FIG.  7   , the second piece includes a seating lip  727  formed on an upper periphery of the conical section  720 , the seating lip  727  being configured to interface with the distal lip  714  of the collar piece  713  when assembled. The third piece of the three-piece product delivery device  710  can include a gasket  725 . As illustrated in  FIG.  7   , the gasket  725  engages the seating lip  727  of the second piece and is compressed between the top end of the container  705 , the seating lip  727  of the conical section  720 , and the distal lip  714  of the collar piece  713 . In some examples, the product delivery device  710  can be manufactured of any combination of materials including, but in no way limited to, polyethylene, polypropylene, polystyrene, polycarbonate, and/or silicone. 
     As illustrated in  FIG.  7   , securement features  715  can operate to secure the wide end of the conical section  720  to the container  705 . In some cases, securement feature  715  can engage with threads of the container  705 . As shown, the threads are formed as protrusions circumferentially formed on the external wall of the bottommost opening of the container, however, in some cases, the securement feature  715  can engage with internal threads of the container  705 . When the securement features  715  of the collar  713  engage with the threads of the container  705 , the seating lip  727  of the second piece and the gasket  725  of the third piece can be positioned between the distal lip  714  of the collar  713  of the first piece and the mouth of the container  705 , such that the intermediate elements are compressed, thereby sealing the interface between the various pieces. The gasket  725  can be made of a flexible material that can be deformed when force is added. The gasket  725  in the system  700  can be deformed to create a seal between the container  705  and the conical section  720 . The gasket  725  can have an internal angle similar in geometry to the conical section  720  to allow smooth flow of product. The securement features  715  and gasket  725  allow for an improved seal between the product delivery device  710  and the container  705 . In some cases, the seal can allow the system  700  to be closed. 
     The conical section  720  can include a wide end and a narrow end. An outlet port  735  can be flush with the narrow end. As illustrated, the outlet port  735  and the inlet port  740  can include one or more external barbs  745  and  750 , respectively. Barbs  745  and  750  allow for tubing to securely connect to each port. In some cases, the barbs  745  and  750  can be important when the system is pressurized to allow tubing to remain connected to the ports. 
     According to an aspect (1) of the present disclosure, a product delivery device is provided. The product delivery device comprises: an inlet port; a conical section including a wide end and a narrow end; an outlet port disposed flush with the narrow end of the conical section extending away from the conical section; and a securement feature formed on the product delivery device, wherein the securement feature is configured to couple the wide end of the conical section to a container. 
     According to an aspect (2) of the present disclosure, the product delivery device of aspect (1) is provided, wherein the diameter of the narrow end is smaller than the diameter of the wide end. 
     According to an aspect (3) of the present disclosure, the product delivery device of aspect (2) is provided, wherein walls of the conical section extend from the wide end to the narrow end and define an angle of the conical section. 
     According to an aspect (4) of the present disclosure, the product delivery device of aspect (4) is provided, wherein, wherein the angle of the conical section varies along a circumference of the narrow end or the wide end. 
     According to an aspect (5) of the present disclosure, the product delivery device of aspect (3) is provided, wherein the angle of the conical section is uniform along a circumference of the narrow end or the wide end. 
     According to an aspect (6) of the present disclosure, the product delivery device of any of aspects (1)-(5) is provided, further comprising a single piece cap including the inlet port, the conical section, the outlet port, and the securement feature. 
     According to an aspect (7) of the present disclosure, the product delivery device of aspect (6) is provided, wherein, wherein the securement feature is configured to form a compression fit with the container. 
     According to an aspect (8) of the present disclosure, the product delivery device of aspect (6) is provided, wherein the cap is formed by injection molding. 
     According to an aspect (9) of the present disclosure, the product delivery device of any of aspects (1)-(8) is provided, further comprising a two-piece cap including the inlet port, the conical section, the outlet port, and the securement feature. 
     According to an aspect (10) of the present disclosure, the product delivery device of aspect (9) is provided, further comprising: a first piece including a stopper; and a second piece including the securement feature, wherein the first piece engages with the second piece to create a seal when connected to the container. 
     According to an aspect (11) of the present disclosure, the product delivery device of any of aspects (1)-(10) is provided, further comprising a three-piece cap including the inlet port, the conical section, the outlet port, and the securement feature. 
     According to an aspect (12) of the present disclosure, the product delivery device of aspect (11) is provided, further comprising: a first piece comprising the inlet port, the conical section and the outlet port; a second piece comprising the securement feature; and a third piece comprising a gasket, wherein the first piece engages with the second piece to deform the gasket when connected to the container. 
     According to an aspect (13) of the present disclosure, the product delivery device of aspect (12) is provided, wherein the gasket comprises an internal angle based at least in part on an angle of the conical section. 
     According to an aspect (14) of the present disclosure, the product delivery device of any of aspects (1)-(13) is provided, wherein the securement feature comprises threads configured to engage an external surface of the container. 
     According to an aspect (15) of the present disclosure, the product delivery device of any of aspects (1)-(14) is provided, wherein the product delivery device comprises at least one of polyethylene, polypropylene, polystyrene, polycarbonate, or silicone. 
     According to an aspect (16) of the present disclosure, the product delivery device of any of aspects (1)-(15) is provided, wherein the inlet port and outlet port comprise an external barb. 
     According to an aspect (17) of the present disclosure, a system for product delivery is provided. The system for product delivery comprises: a container; and a product delivery device comprising: a conical section with a wide end and a narrow end; and an outlet port flush with the narrow end of the conical section, wherein the product is transferred from the conical section through the outlet port. 
     According to an aspect (18) of the present disclosure, the system for product delivery of aspect (17) is provided, further comprising: an inlet port; and a securement feature configured to connect the wide end of the conical section to the container. 
     According to an aspect (19) of the present disclosure, the system for product delivery of aspect (18) is provided, further comprising a dip tube connected to the inlet port and extending into the container to a side opposite the inlet port. 
     According to an aspect (20) of the present disclosure, the system for product delivery of aspect (18) is provided, further comprising a gasket between the product delivery device and the container, the gasket configured to deform to create a hermetic seal. 
     According to an aspect (21) of the present disclosure, the system for product delivery of any of aspects (17)-(20) is provided, wherein the container further comprises a product, the product including a dry free flowing powder. 
     According to an aspect (22) of the present disclosure, the system for product delivery of aspect (21) is provided, wherein the product comprises dissolvable microcarriers. 
     According to an aspect (23) of the present disclosure a system for aseptic dry product delivery is provided. The system for aseptic dry product delivery comprises: a container; a product delivery device including: a conical section with a wide end and a narrow end; and an outlet port disposed flush with the narrow end of the conical section, wherein the dry product is transferred from the conical section through the outlet port; a pressure source connected to an inlet port; and a receiving vessel configured to receive the aseptic dry product. 
     According to an aspect (24) of the present disclosure, the system for product delivery of aspect (23) is provided, further comprising a gasket disposed between the product delivery device and the container, the gasket configured to deform to create a hermetic seal within the system. 
     According to an aspect (25) of the present disclosure, the system for product delivery of any of aspects (23)-(24) is provided, wherein the system is closed to the environment. 
     According to an aspect (26) of the present disclosure, the system for product delivery of any of aspects (23)-(25) is provided, wherein a dip tube connected to the inlet port extends into the container, and wherein the dip tube is configured to transfer pressure from the pressure source into the container. 
     According to an aspect (27) of the present disclosure, the system for product delivery of any of aspects (23)-(26) is provided, wherein the inlet port and outlet port comprise an external barb. 
     According to an aspect (28) of the present disclosure, the system for product delivery of any of aspects (23)-(27) is provided, further comprising: a first tube connected to the inlet port; a first clamp configured to pinch the first tube; a second tube connected to the outlet port; and a second clamp configured to pinch the second tube. 
     According to an aspect (29) of the present disclosure, the system for product delivery of any of aspects (23)-(28) is provided, wherein the container is at least partially filled with an aseptic dry product, the dry product comprising dissolvable microcarriers. 
     According to an aspect (30) of the present disclosure, the system for product delivery of aspect (29) is provided, wherein the dry product is hydrated in the receiving vessel. 
     It should be appreciated that some components, features, and/or configurations can be described in only one embodiment, but these same components, features, and/or configurations can be applied or used in or with many other embodiments and should be considered applicable to the other embodiments, unless stated otherwise or unless such a component, feature, and/or configuration is technically impossible to use with the other embodiment. Thus, the components, features, and/or configurations of the various embodiments can be combined in any manner and such combinations are expressly contemplated and disclosed by this statement. 
     The terms recited in the claims should be given their ordinary and customary meaning as determined by reference to relevant entries in widely used general dictionaries and/or relevant technical dictionaries, commonly understood meanings by those in the art, etc., with the understanding that the broadest meaning imparted by any one or combination of these sources should be given to the claim terms (e.g., two or more relevant dictionary entries should be combined to provide the broadest meaning of the combination of entries, etc.) subject only to the following exceptions: (a) if a term is used in a manner that is more expansive than its ordinary and customary meaning, the term should be given its ordinary and customary meaning plus the additional expansive meaning, or (b) if a term has been explicitly defined to have a different meaning by reciting the term followed by the phrase “as used in this document shall mean” or similar language (e.g., “this term means,” “this term is defined as,” “for the purposes of this disclosure this term shall mean,” etc.). 
     In this disclosure, the term “closed system” can refer to a system that is sealed from the external environment of the system such that the internal and external environments of the system do not interact or have minimized interactions. 
     In this disclosure, the term “aseptic” can refer to the absence of microorganisms. 
     In this disclosure, the term “sterile” can refer to the absence of all microorganisms. 
     References to specific examples, use of “i.e.,” use of the word “invention,” etc., are not meant to invoke exception (b) or otherwise restrict the scope of the recited claim terms. Other than situations where exception (b) applies, nothing contained in this document should be considered a disclaimer or disavowal of claim scope. 
     The subject matter recited in the claims is not coextensive with and should not be interpreted to be coextensive with any embodiment, feature, or combination of features shown in this document. This is true even if only a single embodiment of the feature or combination of features is illustrated and described in this document. Thus, the appended claims should be given their broadest interpretation in view of the prior art and the meaning of the claim terms. 
     Spatial or directional terms, such as “left,” “right,” “front,” “back,” “top,” “bottom,” and the like, relate to the subject matter as it is shown in the drawings. However, it is to be understood that the described subject matter can assume various alternative orientations and, accordingly, such terms are not to be considered as limiting. 
     Articles such as “the,” “a,” and “an” can connote the singular or plural. Also, the word “or” when used without a preceding “either” (or other similar language indicating that “or” is unequivocally meant to be exclusive e.g., only one of x or y, etc.) shall be interpreted to be inclusive (e.g., “x or y” means one or both x or y). 
     The term “and/or” shall also be interpreted to be inclusive (e.g., “x and/or y” means one or both x or y). In situations where “and/or” or “or” are used as a conjunction for a group of three or more items, the group should be interpreted to include one item alone, all the items together, or any combination or number of the items. Moreover, terms used in the specification and claims such as have, having, include, and including should be construed to be synonymous with the terms comprise and comprising. 
     Unless otherwise indicated, all numbers or expressions, such as those expressing dimensions, physical characteristics, and the like, used in the specification (other than the claims) are understood to be modified in all instances by the term “approximately.” At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the claims, each numerical parameter recited in the specification or claims which is modified by the term “approximately” should at least be construed in light of the number of recited significant digits and by applying ordinary rounding techniques. 
     All disclosed ranges are to be understood to encompass and provide support for claims that recite any and all subranges or any and all individual values subsumed by each range. For example, a stated range of 1 to 10 should be considered to include and provide support for claims that recite any and all subranges or individual values that are between and/or inclusive of the minimum value of 1 and the maximum value of 10; that is, all subranges beginning with a minimum value of 1 or more and ending with a maximum value of 10 or less (e.g., 5.5 to 10, 2.34 to 3.56, and so forth) or any values from 1 to 10 (e.g., 3, 5.8, 9.9994, and so forth). 
     All disclosed numerical values are to be understood as being variable from 0-100% in either direction and thus provide support for claims that recite such values or any and all ranges or subranges that can be formed by such values. For example, a stated numerical value of 8 should be understood to vary from 0 to 16 (100% in either direction) and provide support for claims that recite the range itself (e.g., 0 to 16), any subrange within the range (e.g., 2 to 12.5) or any individual value within that range (e.g., 15.2). 
     The operations presented in this document are not inherently related to any particular apparatus. Various general-purpose systems can also be used in accordance with the teachings in this document, or it can prove convenient to construct more specialized apparatuses to perform the required method steps. The required structure for a variety of these systems will be apparent to those of skill in the art, along with equivalent variations. 
     The foregoing description of the embodiments has been provided for purposes of illustration and description. It is not intended to be exhaustive or to limit the disclosure. Individual elements or features of a particular embodiment are generally not limited to that particular embodiment, but, where applicable, are interchangeable and can be used in a selected embodiment, even if not specifically shown or described. The same can also be varied in many ways. Such variations are not to be regarded as a departure from the disclosure, and all such modifications are intended to be included within the scope of the disclosure.