Patent Publication Number: US-2020291442-A1

Title: Production of steviol glycosides in recombinant hosts

Description:
BACKGROUND OF THE INVENTION 
     Field of the Invention 
     This disclosure relates to recombinant production of steviol glycosides, glycosides of steviol precursors, and steviol glycoside precursors in recombinant hosts. In particular, this disclosure relates to production of steviol glycosides comprising steviol-13-O-glucoside (13-SMG), steviol-19-O-glucoside (19-SMG), steviol-1,2-bioside, steviol-1,3-bioside, 1,2-stevioside, 1,3-stevioside, rubusoside, Rebaudioside A (RebA), Rebaudioside B (RebB), Rebaudioside C (RebC), Rebaudioside D (RebD), Rebaudioside E (RebE), Rebaudioside F (RebF), Rebaudioside M (RebM), Rebaudioside Q (RebQ), Rebaudioside I (RebI), dulcoside A, mono-glycosylated ent-kaurenoic acids, di-glycosylated ent-kaurenoic acids, tri-glycosylated ent-kaurenoic acids, mono-glycosylated ent-kaurenols, di-glycosylated ent-kaurenols, tri-glycosylated ent-kaurenols, tri-glycosylated steviol glycosides, tetra-glycosylated steviol glycosides, penta-glycosylated steviol glycosides, hexa-glycosylated steviol glycosides, hepta-glycosylated steviol glycosides, or isomers thereof in recombinant hosts. 
     Description of Related Art 
     Sweeteners are well known as ingredients used most commonly in the food, beverage, or confectionary industries. The sweetener can either be incorporated into a final food product during production or for stand-alone use, when appropriately diluted, as a tabletop sweetener or an at-home replacement for sugars in baking. Sweeteners include natural sweeteners such as sucrose, high fructose corn syrup, molasses, maple syrup, and honey and artificial sweeteners such as aspartame, saccharine, and sucralose.  Stevia  extract is a natural sweetener that can be isolated and extracted from a perennial shrub,  Stevia rebaudiana. Stevia  is commonly grown in South America and Asia for commercial production of  Stevia  extract.  Stevia  extract, purified to various degrees, is used commercially as a high intensity sweetener in foods and in blends or alone as a tabletop sweetener. 
     Chemical structures for several steviol glycosides are shown in  FIG. 2 , including the diterpene steviol and various steviol glycosides. Extracts of the  Stevia  plant generally comprise steviol glycosides that contribute to the sweet flavor, although the amount of each steviol glycoside often varies, inter alia, among different production batches. 
     Recovery and purification of steviol glycosides from the  Stevia  plant have proven to be labor intensive and inefficient. Moreover, steviol glycoside compositions obtained from a plant-derived  Stevia  extract generally contain  Stevia  plant-derived components that can contribute to off-flavors. As such, there remains a need for a recombinant production system that can accumulate high yields of desired steviol glycosides, such as Reb A, RebD, and/or RebM and produce steviol glycoside compositions that are enriched for a one or more desired steviol glycosides relative to a steviol glycoside composition of  Stevia  plant with a reduced level of  Stevia  plant-derived components relative to a steviol glycoside composition obtained from a plant-derived  Stevia  extract. There also remains a need for improved production of steviol glycosides in recombinant hosts for commercial uses. As well, there remains a need for increasing uridine diphosphate glucose (UDP-glucose) formation in recombinant hosts in order to produce higher yields of steviol glycosides, including Reb A, RebD, and/or RebM. 
     SUMMARY OF THE INVENTION 
     It is against the above background that the present invention provides certain advantages over the prior art. 
     Although this invention as disclosed herein is not limited to specific advantages or functionalities (such for example, the ability to scale up production of a one or more steviol glycosides or glycosides of a steviol precursor, purify the one or more steviol glycosides or glycosides of the steviol precursor, and produce steviol glycoside compositions where the different proportions of the various steviol glycosides provide the advantage of having a reduced level of  Stevia  plant-derived components relative to a steviol glycoside composition obtained from a plant-derived  Stevia  extract), the invention provides a recombinant host cell capable of producing one or more steviol glycosides or a steviol glycoside composition in a cell culture, comprising:
         (a) a recombinant gene encoding a polypeptide capable of debranching glycogen; and/or   (b) a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate.       

     In one aspect of the recombinant host cells disclosed herein, the polypeptide capable of debranching glycogen is capable of 4-α-glucanotransferase activity and α-1,6-amyloglucosidase activity. 
     In one aspect, the recombinant host cells disclosed herein further comprise:
         (c) a gene encoding a polypeptide capable of synthesizing uridine 5′-triphosphate (UTP) from uridine diphosphate (UDP);   (d) a gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate; and/or   (e) a gene encoding a polypeptide capable of synthesizing uridine diphosphate glucose (UDP-glucose) from UTP and glucose-1-phosphate.       

     In one aspect of the recombinant host cells disclosed herein:
         (a) the polypeptide capable of debranching glycogen comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:157;   (b) the polypeptide capable of synthesizing glucose-1-phosphate comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:159;   (c) the polypeptide capable of synthesizing UTP from UDP comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:123;   (d) the polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:2, 119, or 143 or a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:141, 145, or 147; and/or   (e) the polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:121 or 127, a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:125, 129, 133, 135, 137, or 139 or a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in SEQ ID NO:131.       

     In one aspect, the recombinant host cells disclosed herein further comprise:
         (a) a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-13 hydroxyl group thereof;   (b) a gene encoding a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside;   (c) a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof;   (d) a gene encoding a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside;   (e) a gene encoding a polypeptide capable of synthesizing geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP);   (f) a gene encoding a polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP;   (g) a gene encoding an a polypeptide capable of synthesizing ent-kaurene from ent-copalyl diphosphate;   (h) a gene encoding a polypeptide capable of synthesizing ent-kaurenoic acid from ent-kaurene;   (i) a gene encoding a polypeptide capable of reducing cytochrome P450 complex; and/or   (j) a gene encoding a polypeptide capable of synthesizing steviol from ent-kaurenoic acid;       

     wherein at least one of the genes is a recombinant gene. 
     In one aspect of the recombinant host cells disclosed herein:
         (a) the polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-13 hydroxyl group thereof comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:7;   (b) the polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside comprises a polypeptide having at least 50% sequence identity to the amino acid sequence set forth in SEQ ID NO:9;   (c) the polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:4;   (d) the polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside comprises a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:11; a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:13; or a polypeptide having at least 65% sequence identity to the amino acid sequence set forth in SEQ ID NO:16;   (e) the polypeptide capable of synthesizing GGPP comprises a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:20, 22, 24, 26, 28, 30, 32, or 116;   (f) the polypeptide capable of synthesizing ent-copalyl diphosphate comprises a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:34, 36, 38, 40, 42, or 120;   (g) the polypeptide capable of synthesizing ent-kaurene comprises a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:44, 46, 48, 50, or 52;   (h) the polypeptide capable of synthesizing ent-kaurenoic acid comprises a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:60, 62, 66, 68, 70, 72, 74, 76, or 117;   (i) the polypeptide capable of reducing cytochrome P450 complex comprises a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:78, 80, 82, 84, 86, 88, 90, 92; and/or   (j) the polypeptide capable of synthesizing steviol comprises a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:94, 97, 100, 101, 102, 103, 104, 106, 108, 110, 112, or 114.       

     In one aspect, the recombinant host cells disclosed herein comprise:
         (a) the gene encoding the polypeptide capable of debranching glycogen having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:157;   (b) the gene encoding the polypeptide capable of synthesizing glucose-1-phosphate having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:159;   (c) the gene encoding the polypeptide capable of synthesizing uridine 5′-triphosphate (UTP) from uridine diphosphate (UDP) having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:123;   (d) the gene encoding the polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate having at least 60% sequence identity to the amino acid sequences set forth in any one of SEQ ID NOs:2 or 119; and   (e) the gene encoding the polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:121; and       

     one or more of:
         (f) the gene encoding the polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-13 hydroxyl group thereof having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:7;   (g) the gene encoding the polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside having at least 50% sequence identity to the amino acid sequence set forth in SEQ ID NO:9;   (h) the gene encoding the polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:4;   (i) the gene encoding the polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside comprises the polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:11; the polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:13; or the polypeptide having at least 65% sequence identity to the amino acid sequence set forth in SEQ ID NO:16;       

     wherein at least one of the genes is a recombinant gene. 
     In one aspect, the recombinant host cells disclosed herein comprise:
         (a) the recombinant gene encoding the polypeptide capable of debranching glycogen having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:157; and/or   (b) the recombinant gene encoding the polypeptide capable of synthesizing glucose-1-phosphate having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:159;   wherein the recombinant gene encoding the polypeptide capable of debranching glycogen and/or the recombinant gene encoding the polypeptide capable of synthesizing glucose-1-phosphate are overexpressed relative to a corresponding host cell lacking the one or more recombinant genes.       

     In one aspect of the recombinant host cells disclosed herein, the gene encoding the polypeptide capable of debranching glycogen and/or the gene encoding the polypeptide capable of synthesizing glucose-1-phosphate are overexpressed by at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% relative to a corresponding host cell lacking the one or more recombinant genes. 
     In one aspect of the recombinant host cells disclosed herein, expression of the one or more recombinant genes increase the amount of UDP-glucose accumulated by the cell relative to a corresponding host lacking the one or more recombinant genes. 
     In one aspect of the recombinant host cells disclosed herein, the expression of the one or more recombinant genes increases the amount of UDP-glucose accumulated by the cell by at least 10%, at least 25%, or at least 50%, at least 100%, at least 150%, at least 200%, or at least 250% relative to a corresponding host lacking the one or more recombinant genes. 
     In one aspect of the recombinant host cells disclosed herein, the expression of the one or more recombinant genes increases an amount of the one or more steviol glycosides or the steviol glycoside composition produced by the cell relative to a corresponding host lacking the one or more recombinant genes. 
     In one aspect of the recombinant host cells disclosed herein, the expression of the one or more recombinant genes increases the amount of the one or more steviol glycosides produced by the cell by at least 5%, or at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% relative to a corresponding host cell lacking the one or more recombinant genes. 
     In one aspect of the recombinant host cells disclosed herein, the expression of the one or more recombinant genes increases an amount of RebA, RebD, and/or RebM produced by the cell by at least 5%, or at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% relative to a corresponding host cell lacking the one or more recombinant genes. 
     In one aspect of the recombinant host cells disclosed herein, the expression of the one or more recombinant genes decreases the amount of the one of one or more steviol glycosides or the steviol glycoside composition accumulated by the cell relative to a corresponding host lacking the one or more recombinant genes. 
     In one aspect of the recombinant host cells disclosed herein, the expression of the one or more recombinant genes decreases the amount of the one or more steviol glycosides accumulated by the cell by at least 5%, or at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50% relative to a corresponding host cell lacking the one or more recombinant genes relative to a corresponding host lacking the one or more recombinant genes. 
     In one aspect of the recombinant host cells disclosed herein, the expression of the one or more recombinant genes decreases an amount of 13-SMG accumulated by the cell relative to a corresponding host lacking the one or more recombinant genes. 
     In one aspect of the recombinant host cells disclosed herein, the expression of the one or more recombinant genes increases the amount of total steviol glycosides produced by the cell by at least 5%, or at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% relative to a corresponding host lacking the one or more recombinant genes. 
     In one aspect of the recombinant host cells disclosed herein, the expression of the one or more recombinant genes decreases the amount of total steviol glycosides produced by the cell by less than 10%, or less than 5%, or less than 2.5% relative to a corresponding host lacking the one or more recombinant genes. 
     In one aspect of the recombinant host cells disclosed herein, the one or more steviol glycosides is, or the steviol glycoside composition comprises, steviol-13-O-glucoside (13-SMG), steviol-1,2-Bioside, steviol-1,3-Bioside, steviol-19-O-glucoside (19-SMG), 1,2-Stevioside, 1,3-stevioside (RebG), rubusoside, rebaudioside A (RebA), rebaudioside B (RebB), rebaudioside C (RebC), rebaudioside D (RebD), rebaudioside E (RebE), rebaudioside F (RebF), rebaudioside M (RebM), rebaudioside Q (RebQ), rebaudioside I (RebI), dulcoside A, and/or an isomer thereof. 
     In one aspect of the recombinant host cells disclosed herein, the recombinant host cell is a plant cell, a mammalian cell, an insect cell, a fungal cell from  Aspergillus  genus or a yeast cell from  Saccharomyces cerevisiae, Schizosaccharomyces pombe, Yarrowia lipolytica, Candida glabrata, Ashbya gossypii, Cyberlindnera jadinii, Pichia pastoris, Kluyveromyces lactis, Hansenula polymorpha, Candida boidinii, Arxula adeninivorans, Xanthophyllomyces dendrorhous,  or  Candida albicans  species, an algal cell or a bacterial cell from  Escherichia coli  species or  Bacillus  genus. 
     In one aspect of the recombinant host cells disclosed herein, the recombinant host cell is a  Saccharomyces cerevisiae  cell. 
     In one aspect of the recombinant host cells disclosed herein, the recombinant host cell is a  Yarrowia lipolytica  cell. 
     The invention also provides a method of producing one or more steviol glycosides or a steviol glycoside composition in a cell culture, comprising culturing the recombinant host cells disclosed herein in the cell culture, under conditions in which the genes are expressed, and wherein the one or more steviol glycosides or the steviol glycoside composition is produced by the recombinant host cell. 
     In one aspect of the methods disclosed herein, the genes are constitutively expressed. 
     In one aspect of the methods disclosed herein, the expression of the genes is induced. 
     In one aspect of the methods disclosed herein, the amount of RebA, RebD, and/or RebM produced by the cell is increased by at least 5%, or at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% relative to a corresponding host lacking the one or more recombinant genes. 
     In one aspect of the methods disclosed herein, the amount of 13-SMG accumulated by the cell is decreased by at least 10%, at least 25%, or at least 50% relative to a corresponding host lacking the one or more recombinant genes. 
     In one aspect of the methods disclosed herein, the amount of total steviol glycosides produced by the cell is increased by at least 5%, or at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% relative to a corresponding host lacking the one or more recombinant genes. 
     In one aspect of the methods disclosed herein, the amount of total steviol glycosides produced by the cell is decreased by less than 10%, or less than 5%, or less than 2.5% relative to a corresponding host lacking the one or more recombinant genes. 
     In one aspect of the methods disclosed herein, the recombinant host cell is grown in a fermentor at a temperature for a period of time, wherein the temperature and period of time facilitate the production of the one or more steviol glycosides or the steviol glycoside composition. 
     In one aspect of the methods disclosed herein, the amount of UDP-glucose accumulated by the cell by at least 10%, at least 25%, or at least 50%, at least 100%, at least 150%, at least 200%, or at least 250% relative to a corresponding host lacking the one or more recombinant genes. 
     In one aspect, the methods disclosed herein further comprise isolating the produced one or more steviol glycosides or the steviol glycoside composition from the cell culture. 
     In one aspect of the methods disclosed herein, the isolating step comprises separating a liquid phase of the cell culture from a solid phase of the cell culture to obtain a supernatant comprising the produced one or more steviol glycosides or the steviol glycoside composition, and:
         (a) contacting the supernatant with one or more adsorbent resins in order to obtain at least a portion of the produced one or more steviol glycosides or the steviol glycoside composition; or   (b) contacting the supernatant with one or more ion exchange or reversed-phase chromatography columns in order to obtain at least a portion of the produced one or more steviol glycosides or the steviol glycoside composition; or   (c) crystallizing or extracting the produced one or more steviol glycosides or the steviol glycoside composition;       

     thereby isolating the produced one or more steviol glycosides or the steviol glycoside composition. 
     In one aspect, the methods disclosed herein further comprise recovering the one or more steviol glycosides or the steviol glycoside composition from the cell culture. 
     In one aspect of the methods disclosed herein, the recovered one or more steviol glycosides or the steviol glycoside composition is enriched for the one or more steviol glycosides relative to a steviol glycoside composition of  Stevia  plant and has a reduced level of  Stevia  plant-derived components relative to a steviol glycoside composition obtained from a plant-derived  Stevia  extract. 
     The invention also provides a method for producing one or more steviol glycosides or a steviol glycoside composition, comprising whole-cell bioconversion of a plant-derived or synthetic steviol and/or steviol glycosides in a cell culture of a recombinant host cell using:
         (a) a polypeptide capable of debranching glycogen, comprising a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:157; and/or   (b) a polypeptide capable of synthesizing glucose-1-phosphate, comprising a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:159; and       

     optionally, one or more of:
         (c) a polypeptide capable of synthesizing UTP from UDP, comprising a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:123;   (d) a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, comprising a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in any one of SEQ ID NO:2, 119, or 143; or at least 55% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:141, 145, or 147; and/or   (e) a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate, comprising a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in any one of SEQ ID NO:121 or 127; at least 55% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:125, 129, 133, 135, 137, or 139; or at least 70% sequence identity to the amino acid sequence set forth in SEQ ID NO:131, and       

     one or more of:
         (f) a polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-13 hydroxyl group thereof;   (g) a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside;   (h) a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof; and/or   (i) a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside;       

     wherein at least one of the polypeptides is a recombinant polypeptide expressed in the recombinant host cell; and producing the one or more steviol glycosides or the steviol glycoside composition thereby. 
     In one aspect of the methods disclosed herein:
         (f) the polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-13 hydroxyl group thereof comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:7;   (g) the polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside comprises a polypeptide having at least 50% sequence identity to the amino acid sequence set forth in SEQ ID NO:9;   (h) the polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:4;   (i) the polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside comprises a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:11; a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:13; or a polypeptide having at least 65% sequence identity to the amino acid sequence set forth in SEQ ID NO:16.       

     In one aspect of the methods disclosed herein, the recombinant host cell is a plant cell, a mammalian cell, an insect cell, a fungal cell from  Aspergillus  genus or a yeast cell from  Saccharomyces cerevisiae, Schizosaccharomyces pombe, Yarrowia lipolytica, Candida glabrata, Ashbya gossypii, Cyberlindnera jadinii, Pichia pastoris, Kluyveromyces lactis, Hansenula polymorpha, Candida boidinii, Arxula adeninivorans, Xanthophyllomyces dendrorhous,  or  Candida albicans  species, an algal cell or a bacterial cell from  Escherichia coli  species or  Bacillus  genus. 
     In one aspect of the methods disclosed herein, the recombinant host cell is a  Saccharomyces cerevisiae  cell. 
     In one aspect of the methods disclosed herein, the recombinant host cell is a  Yarrowia lipolytica  cell. 
     In one aspect of the methods disclosed herein, the one or more steviol glycosides is, or the steviol glycoside composition comprises, steviol-13-O-glucoside (13-SMG), steviol-1,2-Bioside, steviol-1,3-Bioside, steviol-19-O-glucoside (19-SMG), 1,2-stevioside, 1,3-stevioside (RebG), rubusoside, rebaudioside A (RebA), rebaudioside B (RebB), rebaudioside C (RebC), rebaudioside D (RebD), rebaudioside E (RebE), rebaudioside F (RebF), rebaudioside M (RebM), rebaudioside Q (RebQ), rebaudioside I (RebI), dulcoside A, and/or an isomer thereof. 
     The invention also provides a cell culture, comprising the recombinant host cells disclosed herein, the cell culture further comprising:
         (a) the one or more steviol glycosides or the steviol glycoside composition produced by the recombinant host cell;   (b) glucose, fructose, sucrose, xylose, rhamnose, UDP-glucose, UDP-rhamnose, UDP-xylose, and/or N-acetyl-glucosamine; and   (c) supplemental nutrients comprising trace metals, vitamins, salts, YNB, and/or amino acids;       

     wherein the one or more steviol glycosides or the steviol glycoside composition is present at a concentration of at least 1 mg/liter of the cell culture; 
     wherein the cell culture is enriched for the one or more steviol glycosides or the steviol glycoside composition relative to a steviol glycoside composition from a  Stevia  plant and has a reduced level of  Stevia  plant-derived components relative to a plant-derived  Stevia  extract. 
     The invention also provides a cell culture, comprising the recombinant host cells disclosed herein, the cell culture further comprising:
         (a) the one or more steviol glycosides or the steviol glycoside composition produced by the recombinant host cell;   (b) glucose, fructose, sucrose, xylose, rhamnose, UDP-glucose, UDP-rhamnose, UDP-xylose, and/or N-acetyl-glucosamine; and   (c) supplemental nutrients comprising trace metals, vitamins, salts, YNB, and/or amino acids;       

     wherein UDP-glucose is present in the cell culture at a concentration of at least 100 μM; 
     wherein the cell culture is enriched for UGP-glucose relative to a steviol glycoside composition from a  Stevia  plant and has a reduced level of  Stevia  plant-derived components relative to a plant-derived  Stevia  extract. 
     The invention also provides a cell lysate from the recombinant host cells disclosed herein grown in the cell culture, comprising:
         (a) the one or more steviol glycosides or the steviol glycoside composition produced by the recombinant host cell;   (b) glucose, fructose, sucrose, xylose, rhamnose, UDP-glucose, UDP-rhamnose, UDP-xylose, and/or N-acetyl-glucosamine; and/or   (c) supplemental nutrients comprising trace metals, vitamins, salts, yeast nitrogen base, YNB, and/or amino acids;       

     wherein the one or more steviol glycosides or the steviol glycoside composition produced by the recombinant host cell is present at a concentration of at least 1 mg/liter of the cell culture. 
     The invention also provides one or more steviol glycosides produced by the recombinant host cells disclosed herein; 
     wherein the one or more steviol glycosides produced by the recombinant host cell are present in relative amounts that are different from a steviol glycoside composition from a  Stevia  plant and have a reduced level of  Stevia  plant-derived components relative to a plant-derived  Stevia  extract. 
     The invention also provides one or more steviol glycosides produced by the methods disclosed herein; 
     wherein the one or more steviol glycosides produced by the recombinant host cell are present in relative amounts that are different from a steviol glycoside composition from a  Stevia  plant and have a reduced level of  Stevia  plant-derived components relative to a plant-derived  Stevia  extract. 
     The invention also provides a sweetener composition, comprising the one or more steviol glycosides disclosed herein. 
     The invention also provides a food product comprising, the sweetener composition disclosed herein. 
     The invention also provides a beverage or a beverage concentrate, comprising the sweetener composition disclosed herein. 
     These and other features and advantages of the present invention will be more fully understood from the following detailed description taken together with the accompanying claims. It is noted that the scope of the claims is defined by the recitations therein and not by the specific discussion of features and advantages set forth in the present description. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       The following detailed description of the embodiments of the present invention can be best understood when read in conjunction with the following drawings, where like structure is indicated with like reference numerals and in which: 
         FIG. 1  shows the biochemical pathway for producing steviol from geranylgeranyl diphosphate using geranylgeranyl diphosphate synthase (GGPPS), ent-copalyl diphosphate synthase (CDPS), ent-kaurene synthase (KS), ent-kaurene oxidase (KO), and ent-kaurenoic acid hydroxylase (KAH) polypeptides. 
         FIG. 2  shows representative primary steviol glycoside glycosylation reactions catalyzed by suitable UGT enzymes and chemical structures for several of the compounds found in  Stevia  extracts. 
         FIG. 3  shows representative reactions catalyzed by enzymes involved in the UDP-glucose biosynthetic pathway, including uracil permease (FUR4), uracil phosphoribosyltransferase (FUR1), orotate phosphoribosyltransferase 1 (URA5), orotate phosphoribosyltransferase 2 (URA10), orotidine 5′-phosphate decarboxylase (URA3), uridylate kinase (URA6), nucleoside diphosphate kinase (YNK1), phosphoglucomutase-1 (PGM1), phosphoglucomutase-2 (PGM2), UTP-glucose-1-phosphate uridylyltransferase (UGP1), glycogenin glucosyltransferase-1 (GLG1), glycogenin glucosyltransferase-2 (GLG-2), glycogen synthase-1 (GSY1), glycogen synthase-2 (GSY2), glycogen branching enzyme (GLC3), glycogen debranching enzyme (GDB1), and glycogen phosphorylase (GPH1). See, e.g., Daran et al., 1995,  Eur. J. Biochem.  233(2):520-30; François and Parrou, 2001,  FEMS Microbiol. Rev.  25(1):125-45. 
     
    
    
     Skilled artisans will appreciate that elements in the Figures are illustrated for simplicity and clarity and have not necessarily been drawn to scale. For example, the dimensions of some of the elements in the Figures can be exaggerated relative to other elements to help improve understanding of the embodiment(s) of the present invention. 
     DETAILED DESCRIPTION OF THE INVENTION 
     All publications, patents and patent applications cited herein are hereby expressly incorporated by reference for all purposes. 
     Before describing the present invention in detail, a number of terms will be defined. As used herein, the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise. For example, reference to a “nucleic acid” means one or more nucleic acids. 
     It is noted that terms like “preferably,” “commonly,” and “typically” are not utilized herein to limit the scope of the claimed invention or to imply that certain features are critical, essential, or even important to the structure or function of the claimed invention. Rather, these terms are merely intended to highlight alternative or additional features that can or cannot be utilized in a particular embodiment of the present invention. 
     For the purposes of describing and defining the present invention it is noted that the term “substantially” is utilized herein to represent the inherent degree of uncertainty that can be attributed to any quantitative comparison, value, measurement, or other representation. The term “substantially” is also utilized herein to represent the degree by which a quantitative representation can vary from a stated reference without resulting in a change in the basic function of the subject matter at issue. 
     Methods well known to those skilled in the art can be used to construct genetic expression constructs and recombinant cells according to this invention. These methods include in vitro recombinant DNA techniques, synthetic techniques, in vivo recombination techniques, and polymerase chain reaction (PCR) techniques. See, for example, techniques as described in Green &amp; Sambrook, 2012, MOLECULAR CLONING: A LABORATORY MANUAL, Fourth Edition, Cold Spring Harbor Laboratory, New York; Ausubel et al., 1989, CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, Greene Publishing Associates and Wiley Interscience, New York, and PCR Protocols: A Guide to Methods and Applications (Innis et al., 1990, Academic Press, San Diego, Calif.). 
     As used herein, the terms “polynucleotide,” “nucleotide,” “oligonucleotide,” and “nucleic acid” can be used interchangeably to refer to nucleic acid comprising DNA, RNA, derivatives thereof, or combinations thereof, in either single-stranded or double-stranded embodiments depending on context as understood by the skilled worker. 
     As used herein, the terms “microorganism,” “microorganism host,” and “microorganism host cell” can be used interchangeably. As used herein, the terms “recombinant host” and “recombinant host cell” can be used interchangeably. The person of ordinary skill in the art will appreciate that the terms “microorganism,” microorganism host,” and “microorganism host cell,” when used to describe a cell comprising a recombinant gene, may be taken to mean “recombinant host” or “recombinant host cell.” As used herein, the term “recombinant host” is intended to refer to a host, the genome of which has been augmented by at least one DNA sequence. Such DNA sequences include but are not limited to genes that are not naturally present, DNA sequences that are not normally transcribed into RNA or translated into a protein (“expressed”), and other genes or DNA sequences which one desires to introduce into a host. It will be appreciated that typically the genome of a recombinant host described herein is augmented through stable introduction of one or more recombinant genes. Generally, introduced DNA is not originally resident in the host that is the recipient of the DNA, but it is within the scope of this disclosure to isolate a DNA segment from a given host, and to subsequently introduce one or more additional copies of that DNA into the same host, e.g., to enhance production of the product of a gene or alter the expression pattern of a gene. In some instances, the introduced DNA will modify or even replace an endogenous gene or DNA sequence by, e.g., homologous recombination or site-directed mutagenesis. In some aspects, the introduced DNA is introduced into the genome in a location different than where the corresponding endogenous DNA segment originally resided. Suitable recombinant hosts include microorganisms. 
     As used herein, the term “recombinant gene” refers to a gene or DNA sequence that is introduced into a recipient host, regardless of whether the same or a similar gene or DNA sequence may already be present in such a host. “Introduced,” or “augmented” in this context, is known in the art to mean introduced or augmented by the hand of man. Thus, a recombinant gene can be a DNA sequence from another species or can be a DNA sequence that originated from or is present in the same species but has been incorporated into a host by recombinant methods to form a recombinant host. It will be appreciated that a recombinant gene that is introduced into a host can be identical to a DNA sequence that is normally present in the host being transformed, and is introduced to provide one or more additional copies of the DNA to thereby permit overexpression or modified expression of the gene product of that DNA. In some aspects, said recombinant genes are encoded by cDNA. In other embodiments, recombinant genes are synthetic and/or codon-optimized for expression in  S. cerevisiae.    
     As used herein, the term “engineered biosynthetic pathway” refers to a biosynthetic pathway that occurs in a recombinant host, as described herein. In some aspects, one or more steps of the biosynthetic pathway do not naturally occur in an unmodified host. In some embodiments, a heterologous version of a gene is introduced into a host that comprises an endogenous version of the gene. 
     As used herein, the term “endogenous” gene refers to a gene that originates from and is produced or synthesized within a particular organism, tissue, or cell. In some embodiments, the endogenous gene is a yeast gene. In some embodiments, the gene is endogenous to  S. cerevisiae,  including, but not limited to  S. cerevisiae  strain S288C. In some embodiments, an endogenous yeast gene is overexpressed. As used herein, the term “overexpress” is used to refer to the expression of a gene in an organism at levels higher than the level of gene expression in a wild type organism. See, e.g., Prelich, 2012,  Genetics  190:841-54. See, e.g., Giaever &amp; Nislow, 2014,  Genetics  197(2):451-65. In some aspects, overexpression can be performed by integration using the USER cloning system; see, e.g., Nour-Eldin et al., 2010, Methods Mol Biol. 643:185-200. As used herein, the terms “deletion,” “deleted,” “knockout,” and “knocked out” can be used interchangeably to refer to an endogenous gene that has been manipulated to no longer be expressed in an organism, including, but not limited to,  S. cerevisiae.  In some aspects, the terms “deletion,” “deleted,” “knockout,” and “knocked out” can be used interchangeably to refer to an endogenous gene that has been mutated so that the endogenous gene has reduced activity or no activity. 
     As used herein, the terms “heterologous sequence” and “heterologous coding sequence” are used to describe a sequence derived from a species other than the recombinant host. In some embodiments, the recombinant host is an  S. cerevisiae  cell, and a heterologous sequence is derived from an organism other than  S. cerevisiae.  A heterologous coding sequence, for example, can be from a prokaryotic microorganism, a eukaryotic microorganism, a plant, an animal, an insect, or a fungus different than the recombinant host expressing the heterologous sequence. In some embodiments, a coding sequence is a sequence that is native to the host. 
     As used herein, the terms “heterologous sequence” and “heterologous coding sequence” are used to describe a sequence derived from a species other than the recombinant host. In some embodiments, the recombinant host is an  S. cerevisiae  cell, and a heterologous sequence is derived from an organism other than  S. cerevisiae.  A heterologous coding sequence, for example, can be from a prokaryotic microorganism, a eukaryotic microorganism, a plant, an animal, an insect, or a fungus different than the recombinant host expressing the heterologous sequence. In some embodiments, a coding sequence is a sequence that is native to the host. 
     As used herein, the term “constitutive,” “constitutive expression,” or “constitutively expressed” refers to a continuous transcription of a gene resulting in the continuous expression of a protein. 
     As used herein, the term “inducible,” “inducible expression,” or “inducibly expressed” refers to the expression of a gene in response to a stimuli. Stimuli include, but are not limited to, chemicals, stress, or biotic stimuli. 
     A “selectable marker” can be one of any number of genes that complement host cell auxotrophy, provide antibiotic resistance, or result in a color change. Linearized DNA fragments of the gene replacement vector then are introduced into the cells using methods well known in the art (see below). Integration of the linear fragments into the genome and the disruption of the gene can be determined based on the selection marker and can be verified by, for example, PCR or Southern blot analysis. Subsequent to its use in selection, a selectable marker can be removed from the genome of the host cell by, e.g., Cre-LoxP systems (see, e.g., Gossen et al., 2002,  Ann. Rev. Genetics  36:153-173 and U.S. 2006/0014264). Alternatively, a gene replacement vector can be constructed in such a way as to include a portion of the gene to be disrupted, where the portion is devoid of any endogenous gene promoter sequence and encodes none, or an inactive fragment of, the coding sequence of the gene. 
     As used herein, the terms “variant” and “mutant” are used to describe a protein sequence that has been modified at one or more amino acids, compared to the wild-type sequence of a particular protein. 
     As used herein, the term “inactive fragment” is a fragment of the gene that encodes a protein having, e.g., less than 10% (e.g., less than 9%, less than 8%, less than 7%, less than 6%, less than 5%, less than 4%, less than 3%, less than 2%, less than 1%, or 0%) of the activity of the protein produced from the full-length coding sequence of the gene. Such a portion of a gene is inserted in a vector in such a way that no known promoter sequence is operably linked to the gene sequence, but that a stop codon and a transcription termination sequence are operably linked to the portion of the gene sequence. This vector can be subsequently linearized in the portion of the gene sequence and transformed into a cell. By way of single homologous recombination, this linearized vector is then integrated in the endogenous counterpart of the gene with inactivation thereof. 
     As used herein, the term “steviol glycoside” refers to rebaudioside A (RebA) (CAS #58543-16-1), rebaudioside B (RebB) (CAS #58543-17-2), rebaudioside C (RebC) (CAS #63550-99-2), rebaudioside D (RebD) (CAS #63279-13-0), rebaudioside E (RebE) (CAS #63279-14-1), rebaudioside F (RebF) (CAS #438045-89-7), rebaudioside M (RebM) (CAS #1220616-44-3), Rubusoside (CAS #63849-39-4), Dulcoside A (CAS #64432-06-0), rebaudioside I (RebI) (MassBank Record: FU000332), rebaudioside Q (RebQ), 1,2-Stevioside (CAS #57817-89-7), 1,3-Stevioside (RebG), Steviol-1,2-Bioside (MassBank Record: FU000299), Steviol-1,3-Bioside, Steviol-13-O-glucoside (13-SMG), Steviol-19-O-glucoside (19-SMG), a tri-glycosylated steviol glycoside, a tetra-glycosylated steviol glycoside, a penta-glycosylated steviol glycoside, a hexa-glycosylated steviol glycoside, a hepta-glycosylated steviol glycoside, and isomers thereof. See  FIG. 2 ; see also, Steviol Glycosides Chemical and Technical Assessment 69th JECFA, 2007, prepared by Harriet Wallin, Food Agric. Org. 
     As used herein, the terms “steviol glycoside precursor” and “steviol glycoside precursor compound” are used to refer to intermediate compounds in the steviol glycoside biosynthetic pathway. Steviol glycoside precursors include, but are not limited to, geranylgeranyl diphosphate (GGPP), ent-copalyl-diphosphate, ent-kaurene, ent-kaurenol, ent-kaurenal, ent-kaurenoic acid, and steviol. See  FIG. 1 . In some embodiments, steviol glycoside precursors are themselves steviol glycoside compounds. For example, 19-SMG, rubusoside, 1,2-stevioside, and RebE are steviol glycoside precursors of RebM. See  FIG. 2 . Also as used herein, the terms “steviol precursor” and “steviol precursor compound” are used to refer to intermediate compounds in the steviol biosynthetic pathway. Steviol precursors may also be steviol glycoside precursors, and include, but are not limited to, geranylgeranyl diphosphate (GGPP), ent-copalyl-diphosphate, ent-kaurene, ent-kaurenol, ent-kaurenal, and ent-kaurenoic acid. 
     As used herein, the term “contact” is used to refer to any physical interaction between two objects. For example, the term “contact” may refer to the interaction between an enzyme and a substrate. In another example, the term “contact” may refer to the interaction between a liquid (e.g., a supernatant) and an adsorbent resin. 
     Steviol glycosides and/or steviol glycoside precursors can be produced in vivo (i.e., in a recombinant host), in vitro (i.e., enzymatically), or by whole cell bioconversion. As used herein, the terms “produce” and “accumulate” can be used interchangeably to describe synthesis of steviol glycosides and steviol glycoside precursors in vivo, in vitro, or by whole cell bioconversion. 
     As used herein, the terms “culture broth,” “culture medium,” and “growth medium” can be used interchangeably to refer to a liquid or solid that supports growth of a cell. A culture broth can comprise glucose, fructose, sucrose, trace metals, vitamins, salts, yeast nitrogen base (YNB), and/or amino acids. The trace metals can be divalent cations, including, but not limited to, Mn 2+  and/or Mg 2+ . In some embodiments, Mn 2+  can be in the form of MnCl 2  dihydrate and range from approximately 0.01 g/L to 100 g/L. In some embodiments, Mg 2+  can be in the form of MgSO 4  heptahydrate and range from approximately 0.01 g/L to 100 g/L. For example, a culture broth can comprise i) approximately 0.02-0.03 g/L MnCl 2  dihydrate and approximately 0.5-3.8 g/L MgSO 4  heptahydrate, ii) approximately 0.03-0.06 g/L MnCl 2  dihydrate and approximately 0.5-3.8 g/L MgSO 4  heptahydrate, and/or iii) approximately 0.03-0.17 g/L MnCl 2  dihydrate and approximately 0.5-7.3 g/L MgSO 4  heptahydrate. Additionally, a culture broth can comprise one or more steviol glycosides produced by a recombinant host, as described herein. 
     Recombinant steviol glycoside-producing  Saccharomyces cerevisiae  ( S. cerevisiae ) strains are described in WO 2011/153378, WO 2013/022989, WO 2014/122227, and WO 2014/122328, each of which is incorporated by reference in their entirety. Methods of producing steviol glycosides in recombinant hosts, by whole cell bio-conversion, and in vitro are also described in WO 2011/153378, WO 2013/022989, WO 2014/122227, and WO 2014/122328. 
     In some embodiments, a recombinant host comprising a gene encoding a polypeptide capable of synthesizing geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP) (e.g., a geranylgeranyl diphosphate synthase (GGPPS) polypeptide); a gene encoding a polypeptide capable of synthesizing ent-copalyldiphosphate from GGPP (e.g., a ent-copalyl diphosphate synthase (CDPS) polypeptide); a gene encoding a polypeptide capable of synthesizing ent-kaurene from ent-copalyl diphosphate (e.g., a kaurene synthase (KS) polypeptide); a gene encoding a polypeptide capable of synthesizing ent-kaurenoic acid, ent-kaurenol, and/or ent-kaurenal from ent-kaurene (e.g., a kaurene oxidase (KO) polypeptide); a gene encoding a polypeptide capable of reducing cytochrome P450 complex (e.g., a cytochrome P450 reductase (CPR) polypeptide or a P450 oxidoreductase (POR) polypeptide; for example, but not limited to a polypeptide capable of electron transfer from NADPH to cytochrome P450 complex during conversion of NADPH to NADP + , which is utilized as a cofactor for terpenoid biosynthesis); a gene encoding a polypeptide capable of synthesizing steviol from ent-kaurenoic acid (e.g., a steviol synthase (KAH) polypeptide); and/or a gene encoding a bifunctional polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP and synthesizing ent-kaurene from ent-copalyl diphosphate (e.g., an ent-copalyl diphosphate synthase (CDPS)—ent-kaurene synthase (KS) polypeptide) can produce steviol in vivo. See, e.g.,  FIG. 1 . The skilled worker will appreciate that one or more of these genes can be endogenous to the host provided that at least one (and in some embodiments, all) of these genes is a recombinant gene introduced into the recombinant host. 
     In some embodiments, a recombinant host comprising a gene encoding a polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-13 hydroxyl group (e.g., a UGT85C2 polypeptide); a gene encoding a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside (e.g., a UGT76G1 polypeptide); a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group (e.g., a UGT74G1 polypeptide); and/or a gene encoding a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside (e.g., a UGT91D2 or a EUGT11 polypeptide) can produce a steviol glycoside in vivo. The skilled worker will appreciate that one or more of these genes can be endogenous to the host provided that at least one (and in some embodiments, all) of these genes is a recombinant gene introduced into the recombinant host. 
     In some embodiments, steviol glycosides and/or steviol glycoside precursors are produced in vivo through expression of one or more enzymes involved in the steviol glycoside biosynthetic pathway in a recombinant host. For example, a recombinant host comprising a gene encoding a polypeptide capable of synthesizing GGPP from FPP and IPP; a gene encoding a polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP; a gene encoding a polypeptide capable of synthesizing ent-kaurene from ent-copalyl diphosphate; a gene encoding a polypeptide capable of synthesizing ent-kaurenoic acid, ent-kaurenol, and/or ent-kaurenal from ent-kaurene; a gene encoding a polypeptide capable of reducing cytochrome P450 complex; a gene encoding a bifunctional polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP and synthesizing ent-kaurene from ent-copalyl diphosphate; a gene encoding a polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-13 hydroxyl group; a gene encoding a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group; and/or a gene encoding a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside can produce a steviol glycoside and/or steviol glycoside precursors in vivo. See, e.g.,  FIGS. 1 and 2 . The skilled worker will appreciate that one or more of these genes can be endogenous to the host provided that at least one (and in some embodiments, all) of these genes is a recombinant gene introduced into the recombinant host. 
     In some embodiments, a steviol-producing recombinant microorganism comprises heterologous nucleic acids encoding a polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-13 hydroxyl group; a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group; and a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside. 
     In some embodiments, a steviol-producing recombinant microorganism comprises heterologous nucleic acids encoding a polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-13 hydroxyl group, a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside, and a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside polypeptides. 
     In some aspects, a polypeptide capable of glycosylating steviol or a steviol glycoside at its C-13 hydroxyl group, a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside, a polypeptide capable of glycosylating steviol or the steviol glycoside at its C-19 carboxyl group, and/or a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside, transfers a glucose molecule from uridine diphosphate glucose (UDP-glucose) to steviol and/or a steviol glycoside. 
     In some aspects, UDP-glucose is produced in vivo through expression of one or more enzymes involved in the UDP-glucose biosynthetic pathway in a recombinant host. For example, a recombinant host comprising a gene encoding a polypeptide capable of transporting uracil into the host cell (e.g., uracil permease (FUR4)); a gene encoding a polypeptide capable of synthesizing uridine monophosphate (UMP) from uracil (e.g., uracil phosphoribosyltransferase (FUR1)); a gene encoding a polypeptide capable of synthesizing orotidine monophosphate (OMP) from orotate or orotic acid (e.g., orotate phosphoribosyltransferase 1 (URA5) and orotate phosphoribosyltransferase 2 (URA10)); a gene encoding a polypeptide capable of synthesizing UMP from OMP (e.g., orotidine 5′-phosphate decarboxylase (URA3)); a gene encoding a polypeptide capable of synthesizing uridine diphosphate (UDP) from UMP (e.g., uridylate kinase (URA6)); a gene encoding a polypeptide capable of synthesizing uridine 5′-triphosphate (UTP) from UDP (i.e., a polypeptide capable of catalyzing the transfer of gamma phosphates from nucleoside triphosphates, e.g., nucleoside diphosphate kinase (YNK1)); a gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., phosphoglucomutase-1 (PGM1) and phosphoglucomutase-2 (PGM2)); a gene encoding a polypeptide capable of debranching glycogen (e.g., glycogen debranching enzyme (GDB1)); a gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., glycogen phosphorylase (GPH1)); and/or a gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., UTP-glucose-1-phosphate uridylyltransferase (UGP1)) can produce UDP-glucose in vivo. See, e.g.,  FIG. 3 . The skilled worker will appreciate that one or more of these genes may be endogenous to the host. 
     In some embodiments, a recombinant host comprises a gene encoding a polypeptide capable of synthesizing UTP from UDP. In some aspects, the gene encoding a polypeptide capable of synthesizing UTP from UDP is a recombinant gene. In some aspects, the recombinant gene comprises a nucleotide sequence native to the host. In other aspects, the recombinant gene comprises a heterologous nucleotide sequence. In some aspects, the recombinant gene is operably linked to a promoter. In some aspects, the recombinant gene is operably linked to a terminator, for example but not limited to, tCYC1 (SEQ ID NO:154) or tADH1 (SEQ ID NO:155). In some aspects, the promoter and terminator drive high expression of the recombinant gene. In some aspects, the recombinant gene is operably linked to a strong promoter, for example but not limited to, pTEF1 (SEQ ID NO:148), pPGK1 (SEQ ID NO:149), pTDH3 (SEQ ID NO:150), pTEF2 (SEQ ID NO:151), pTPI1 (SEQ ID NO:152), or pPDC1 (SEQ ID NO:153). In some aspects, the recombinant gene comprises a nucleotide sequence that originated from or is present in the same species as the recombinant host. In some aspects, expression of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP results in a total expression level of genes encoding a polypeptide capable of synthesizing UTP from UDP that is higher than the expression level of endogenous genes encoding a polypeptide capable of synthesizing UTP from UDP, i.e., an overexpression of a polypeptide capable of synthesizing UTP from UDP. 
     In some aspects, the gene encoding the polypeptide capable of synthesizing UTP from UDP is a gene present in the same species as the recombinant host, i.e., an endogenous gene. In some embodiments, the wild-type promoter of an endogenous gene encoding the polypeptide capable of synthesizing UTP from UDP can be exchanged for a strong promoter. In some aspects, the strong promoter drives high expression of the endogenous gene (i.e., overexpression of the gene). In other embodiments, the wild-type enhancer of an endogenous gene encoding a polypeptide capable of synthesizing UTP from UDP can be exchanged for a strong enhancer. In some embodiments, the strong enhancer drives high expression of the endogenous gene (i.e., overexpression of the gene). In some embodiments, both the wild-type enhancer (i.e., operably linked to the promoter) and the wild-type promoter (i.e., operably linked to the endogenous gene) of the endogenous gene can be exchanged for a strong enhancer and strong promoter, respectively, resulting in overexpression of a polypeptide capable of synthesizing UTP from UDP (i.e., relative to the expression level of endogenous genes operably linked to wild-type enhancers and/or promoters). The endogenous gene operably linked to the strong enhancer and/or promoter may be located at the native loci, and/or may be located elsewhere in the genome. 
     For example, in some embodiments, a recombinant host comprising an endogenous gene encoding a polypeptide capable of synthesizing UTP from UDP, operably linked to a wild-type promoter, further comprises a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP, comprising a nucleotide sequence native to the host, operably linked to, e.g., a wild-type promoter, a promoter native to the host, or a heterologous promoter. In another example, in some embodiments, a recombinant host comprising an endogenous gene encoding a polypeptide capable of synthesizing UTP from UDP, operably linked to a wild-type promoter, further comprises a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP, comprising a heterologous nucleotide sequence, operably linked to, e.g., a wild-type promoter, a promoter native to the host, or a heterologous promoter. In yet another example, in some embodiments, a recombinant host comprises an endogenous gene encoding a polypeptide capable of synthesizing UTP from UDP, operably linked to, e.g., a strong promoter native to the host, or a heterologous promoter. 
     The person of ordinary skill in the art will appreciate that, e.g., expression of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP; expression of a recombinant gene and an endogenous gene encoding a polypeptide capable of synthesizing UTP from UDP, and expression of an endogenous gene encoding a polypeptide capable of synthesizing UTP from UDP, wherein the wild-type promoter and/or enhancer of the endogenous gene are exchanged for a strong promoter and/or enhancer, each result in overexpression of a polypeptide capable of synthesizing UTP from UDP relative to a corresponding host not expressing a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP and/or a corresponding host expressing only a native gene encoding a polypeptide capable of synthesizing UTP from UDP, operably linked to the wild-type promoter and enhancer—i.e., as used herein, the term “expression” may include “overexpression.” 
     In some embodiments, a polypeptide capable of synthesizing UTP from UDP is overexpressed such that the total expression level of genes encoding the polypeptide capable of synthesizing UTP from UDP is at least 5% higher than the expression level of endogenous genes encoding a polypeptide capable of synthesizing UTP from UDP. In some embodiments, the total expression level of genes encoding a polypeptide capable of synthesizing UTP from UDP is at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% higher than the expression level of endogenous genes encoding a polypeptide capable of synthesizing UTP from UDP. 
     In some embodiments, a recombinant host comprises a gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate. In some aspects, the gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate is a recombinant gene. In some aspects, the recombinant gene comprises a nucleotide sequence native to the host. In other aspects, the recombinant gene comprises a heterologous nucleotide sequence. In some aspects, the recombinant gene is operably linked to a promoter. In some aspects, the recombinant gene is operably linked to a terminator, for example but not limited to, tCYC1 (SEQ ID NO:154) or tADH1 (SEQ ID NO:155). In some aspects, the promoter and terminator drive high expression of the recombinant gene. In some aspects, the recombinant gene is operably linked to a strong promoter, for example but not limited to, pTEF1 (SEQ ID NO:148), pPGK1 (SEQ ID NO:149), pTDH3 (SEQ ID NO:150), pTEF2 (SEQ ID NO:151), pTPI1 (SEQ ID NO:152), or pPDC1 (SEQ ID NO:153). In some aspects, the recombinant gene comprises a nucleotide sequence that originated from or is present in the same species as the recombinant host. In some aspects, expression of a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate results in a total expression level of genes encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate that is higher than the expression level of endogenous genes encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, i.e., an overexpression of a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate. 
     In some aspects, the gene encoding the polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate is a gene present in the same species as the recombinant host, i.e., an endogenous gene. In some embodiments, the wild-type promoter of an endogenous gene encoding the polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate can be exchanged for a strong promoter. In some aspects, the strong promoter drives high expression of the endogenous gene (i.e., overexpression of the gene). In other embodiments, the wild-type enhancer of an endogenous gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate can be exchanged for a strong enhancer. In some embodiments, the strong enhancer drives high expression of the endogenous gene (i.e., overexpression of the gene). In some embodiments, both the wild-type enhancer (i.e., operably linked to the promoter) and the wild-type promoter (i.e., operably linked to the endogenous gene) of the endogenous gene can be exchanged for a strong enhancer and strong promoter, respectively, resulting in overexpression of a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate (i.e., relative to the expression level of endogenous genes operably linked to wild-type enhancers and/or promoters). The endogenous gene operably linked to the strong enhancer and/or promoter may be located at the native loci, and/or may be located elsewhere in the genome. 
     For example, in some embodiments, a recombinant host comprising an endogenous gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, operably linked to a wild-type promoter, further comprises a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, comprising a nucleotide sequence native to the host, operably linked to, e.g., a wild-type promoter, a promoter native to the host, or a heterologous promoter. In another example, in some embodiments, a recombinant host comprising an endogenous gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, operably linked to a wild-type promoter, further comprises a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, comprising a heterologous nucleotide sequence, operably linked to, e.g., a wild-type promoter, a promoter native to the host, or a heterologous promoter. In yet another example, in some embodiments, a recombinant host comprises an endogenous gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, operably linked to, e.g., a strong promoter native to the host, or a heterologous promoter. 
     In some embodiments, a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate is overexpressed such that the total expression level of genes encoding the polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate is at least 5% higher than the expression level of endogenous genes encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate. In some embodiments, the total expression level of genes encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate is at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% higher than the expression level of endogenous genes encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate. 
     In some embodiments, a recombinant host comprises a gene encoding a polypeptide capable of debranching glycogen. In some aspects, debranching glycogen comprises glycogen breakdown and/or glucose mobilization. In some aspects, debranching glycogen comprises breakdown of glycogen into glucose-1-phosphate. In some aspects, the polypeptide capable of debranching glycogen comprises a polypeptide capable of intramolecularly transferring α-1,4-linked glucose and/or α-1,4-linked glucan of glycogen to a new position (i.e., 4-α-glucanotransferase activity), and/or capable of hydrolyzing an α-1,6 linkage of glycogen (i.e., α-1,6-amyloglucosidase activity). In some aspects, the polypeptide capable of debranching glycogen comprises a bifunctional polypeptide capable of 4-α-glucanotransferase activity and capable of α-1,6-amyloglucosidase activity. In some aspects, the recombinant host can comprise a first polypeptide capable of 4-α-glucanotransferase activity and a second peptide capable of α-1,6-amyloglucosidase activity. In some aspects, the gene encoding a polypeptide capable of debranching glycogen is a recombinant gene. In some aspects, the recombinant gene comprises a nucleotide sequence native to the host. In other aspects, the recombinant gene comprises a heterologous nucleotide sequence. In some aspects, the recombinant gene is operably linked to a promoter. In some aspects, the recombinant gene is operably linked to a terminator, for example but not limited to, tCYC1 (SEQ ID NO:154) or tADH1 (SEQ ID NO:155). In some aspects, the promoter and terminator drive high expression of the recombinant gene. In some aspects, the recombinant gene is operably linked to a strong promoter, for example but not limited to, pTEF1 (SEQ ID NO:148), pPGK1 (SEQ ID NO:149), pTDH3 (SEQ ID NO:150), pTEF2 (SEQ ID NO:151), pTPI1 (SEQ ID NO:152), or pPDC1 (SEQ ID NO:153). In some aspects, the recombinant gene comprises a nucleotide sequence that originated from or is present in the same species as the recombinant host. In some aspects, expression of a recombinant gene encoding a polypeptide capable of debranching glycogen results in a total expression level of genes encoding a polypeptide capable of debranching glycogen that is higher than the expression level of endogenous genes encoding a polypeptide capable of debranching glycogen, i.e., an overexpression of a polypeptide capable of debranching glycogen. 
     In some aspects, the gene encoding the polypeptide capable of debranching glycogen is a gene present in the same species as the recombinant host, i.e., an endogenous gene. In some embodiments, the wild-type promoter of an endogenous gene encoding the polypeptide capable of debranching glycogen can be exchanged for a strong promoter. In some aspects, the strong promoter drives high expression of the endogenous gene (i.e., overexpression of the gene). In other embodiments, the wild-type enhancer of an endogenous gene encoding a polypeptide capable of debranching glycogen can be exchanged for a strong enhancer. In some embodiments, the strong enhancer drives high expression of the endogenous gene (i.e., overexpression of the gene). In some embodiments, both the wild-type enhancer (i.e., operably linked to the promoter) and the wild-type promoter (i.e., operably linked to the endogenous gene) of the endogenous gene can be exchanged for a strong enhancer and strong promoter, respectively, resulting in overexpression of a polypeptide capable of debranching glycogen (i.e., relative to the expression level of endogenous genes operably linked to wild-type enhancers and/or promoters). The endogenous gene operably linked to the strong enhancer and/or promoter may be located at the native loci, and/or may be located elsewhere in the genome. 
     For example, in some embodiments, a recombinant host comprising an endogenous gene encoding a polypeptide capable of debranching glycogen, operably linked to a wild-type promoter, further comprises a recombinant gene encoding a polypeptide capable of debranching glycogen, comprising a nucleotide sequence native to the host, operably linked to, e.g., a wild-type promoter, a promoter native to the host, or a heterologous promoter. In another example, in some embodiments, a recombinant host comprising an endogenous gene encoding a polypeptide capable of debranching glycogen, operably linked to a wild-type promoter, further comprises a recombinant gene encoding a polypeptide capable of debranching glycogen, comprising a heterologous nucleotide sequence, operably linked to, e.g., a wild-type promoter, a promoter native to the host, or a heterologous promoter. In yet another example, in some embodiments, a recombinant host comprises an endogenous gene encoding a polypeptide capable of debranching glycogen, operably linked to, e.g., a strong promoter native to the host, or a heterologous promoter. 
     In some embodiments, a polypeptide capable of debranching glycogen is overexpressed such that the total expression level of genes encoding the polypeptide capable of debranching glycogen is at least 5% higher than the expression level of endogenous genes encoding a polypeptide capable of debranching glycogen. In some embodiments, the total expression level of genes encoding a polypeptide capable of debranching glycogen is at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% higher than the expression level of endogenous genes encoding a polypeptide capable of debranching glycogen. 
     In some embodiments, a recombinant host comprises a gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen. In some aspects, the gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen comprises a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and an α-1,4-linked glucose of glycogen. In some aspects, the gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen is a recombinant gene. In some aspects, the recombinant gene comprises a nucleotide sequence native to the host. In other aspects, the recombinant gene comprises a heterologous nucleotide sequence. In some aspects, the recombinant gene is operably linked to a promoter. In some aspects, the recombinant gene is operably linked to a terminator, for example but not limited to, tCYC1 (SEQ ID NO:154) or tADH1 (SEQ ID NO:155). In some aspects, the promoter and terminator drive high expression of the recombinant gene. In some aspects, the recombinant gene is operably linked to a strong promoter, for example but not limited to, pTEF1 (SEQ ID NO:148), pPGK1 (SEQ ID NO:149), pTDH3 (SEQ ID NO:150), pTEF2 (SEQ ID NO:151), pTPI1 (SEQ ID NO:152), or pPDC1 (SEQ ID NO:153). In some aspects, the recombinant gene comprises a nucleotide sequence that originated from or is present in the same species as the recombinant host. In some aspects, expression of a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen results in a total expression level of genes encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen that is higher than the expression level of endogenous genes encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, i.e., an overexpression of a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen. 
     In some aspects, the gene encoding the polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen is a gene present in the same species as the recombinant host, i.e., an endogenous gene. In some embodiments, the wild-type promoter of an endogenous gene encoding the polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen can be exchanged for a strong promoter. In some aspects, the strong promoter drives high expression of the endogenous gene (i.e., overexpression of the gene). In other embodiments, the wild-type enhancer of an endogenous gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen can be exchanged for a strong enhancer. In some embodiments, the strong enhancer drives expression of the endogenous gene (i.e., overexpression of the gene). In some embodiments, both the wild-type enhancer (i.e., operably linked to the promoter) and the wild-type promoter (i.e., operably linked to the endogenous gene) of the endogenous gene can be exchanged for a strong enhancer and strong promoter, respectively, resulting in overexpression of a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen (i.e., relative to the expression level of endogenous genes operably linked to wild-type enhancers and/or promoters). The endogenous gene operably linked to the strong enhancer and/or promoter may be located at the native loci, and/or may be located elsewhere in the genome. 
     For example, in some embodiments, a recombinant host comprising an endogenous gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, operably linked to a wild-type promoter, further comprises a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, comprising a nucleotide sequence native to the host, operably linked to, e.g., a wild-type promoter, a promoter native to the host, or a heterologous promoter. In another example, in some embodiments, a recombinant host comprising an endogenous gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, operably linked to a wild-type promoter, further comprises a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, comprising a heterologous nucleotide sequence, operably linked to, e.g., a wild-type promoter, a promoter native to the host, or a heterologous promoter. In yet another example, in some embodiments, a recombinant host comprises an endogenous gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, operably linked to, e.g., a strong promoter native to the host, or a heterologous promoter. 
     In some embodiments, a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen is overexpressed such that the total expression level of genes encoding the polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen is at least 5% higher than the expression level of endogenous genes encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen. In some embodiments, the total expression level of genes encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen is at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% higher than the expression level of endogenous genes encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen. 
     In some embodiments, a recombinant host comprises a gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate. In some aspects, the gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate is a recombinant gene. In some aspects, the recombinant gene comprises a nucleotide sequence native to the host. In other aspects, the recombinant gene comprises a heterologous nucleotide sequence. In some aspects, the recombinant gene is operably linked to a promoter. In some aspects, the recombinant gene is operably linked to a terminator, for example but not limited to, tCYC1 (SEQ ID NO:154) or tADH1 (SEQ ID NO:155). In some aspects, the promoter and terminator drive high expression of the recombinant gene. In some aspects, the recombinant gene is operably linked to a strong promoter, for example but not limited to, pTEF1 (SEQ ID NO:148), pPGK1 (SEQ ID NO:149), pTDH3 (SEQ ID NO:150), pTEF2 (SEQ ID NO:151), pTPI1 (SEQ ID NO:152), or pPDC1 (SEQ ID NO:153). In some aspects, the recombinant gene comprises a nucleotide sequence that originated from or is present in the same species as the recombinant host. In some aspects, expression of a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate results in a total expression level of genes encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate that is higher than the expression level of endogenous genes encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate, i.e., an overexpression of a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate. 
     In some aspects, the gene encoding the polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate is a gene present in the same species as the recombinant host, i.e., an endogenous gene. In some embodiments, the wild-type promoter of an endogenous gene encoding the polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate can be exchanged for a strong promoter. In some aspects, the strong promoter drives high expression of the endogenous gene (i.e., overexpression of the gene). In other embodiments, the wild-type enhancer of an endogenous gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate can be exchanged for a strong enhancer. In some embodiments, the strong enhancer drives high expression of the endogenous gene (i.e., overexpression of the gene). In some embodiments, both the wild-type enhancer (i.e., operably linked to the promoter) and the wild-type promoter (i.e., operably linked to the endogenous gene) of the endogenous gene can be exchanged for a strong enhancer and strong promoter, respectively, resulting in overexpression of a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (i.e., relative to the expression level of endogenous genes operably linked to wild-type enhancers and/or promoters). The endogenous gene operably linked to the strong enhancer and/or promoter may be located at the native loci, and/or may be located elsewhere in the genome. 
     For example, in some embodiments, a recombinant host comprising an endogenous gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate, operably linked to a wild-type promoter, further comprises a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate, comprising a nucleotide sequence native to the host, operably linked to, e.g., a wild-type promoter, a promoter native to the host, or a heterologous promoter. In another example, in some embodiments, a recombinant host comprising an endogenous gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate, operably linked to a wild-type promoter, further comprises a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate, comprising a heterologous nucleotide sequence, operably linked to, e.g., a wild-type promoter, a promoter native to the host, or a heterologous promoter. In yet another example, in some embodiments, a recombinant host comprises an endogenous gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate, operably linked to, e.g., a strong promoter native to the host, or a heterologous promoter. 
     In some embodiments, a recombinant host comprising a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate is overexpressed such that the total expression level of genes encoding the polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate is at least 5% higher than the expression level of endogenous genes encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate. In some embodiments, the total expression level of genes encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate is at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% higher than the expression level of endogenous genes encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate. 
     In some aspects, a recombinant host comprising one or more genes encoding one or more polypeptides capable of synthesizing UTP from UDP, one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate, one or more genes encoding one or more polypeptide capable of debranching glycogen, one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate may further comprise a recombinant gene encoding a polypeptide capable of transporting uracil into the host cell; a recombinant gene encoding a polypeptide capable of synthesizing uridine monophosphate (UMP) from uracil; a recombinant gene encoding a polypeptide capable of synthesizing orotidine monophosphate (OMP) from orotate or orotic acid; a recombinant gene encoding a polypeptide capable of synthesizing UMP from OMP; and/or a recombinant gene encoding a polypeptide capable of synthesizing uridine diphosphate (UDP) from UMP. In some embodiments, a recombinant host comprising one or more genes encoding one or more polypeptides capable of synthesizing UTP from UDP, one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate, one or more genes encoding one or more polypeptides capable of debranching glycogen, one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate may overexpress a gene encoding a polypeptide capable of transporting uracil into the host cell; a gene encoding a polypeptide capable of synthesizing uridine monophosphate (UMP) from uracil; a gene encoding a polypeptide capable of synthesizing orotidine monophosphate (OMP) from orotate or orotic acid; a gene encoding a polypeptide capable of synthesizing UMP from OMP; and/or a gene encoding a polypeptide capable of synthesizing uridine diphosphate (UDP) from UMP. 
     In some aspects, the polypeptide capable of synthesizing UTP from UDP comprises a polypeptide having the amino acid sequence set forth in SEQ ID NO:123 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:122). 
     In some aspects, the polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate comprises a polypeptide having the amino acid sequence set forth in SEQ ID NO:2 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:1), SEQ ID NO:119 (encoded by the nucleotide sequence set forth in SEQ ID NO:118), SEQ ID NO:141 (encoded by the nucleotide sequence set forth in SEQ ID NO:140), SEQ ID NO:143 (encoded by the nucleotide sequence set forth in SEQ ID NO:142), SEQ ID NO:145 (encoded by the nucleotide sequence set forth in SEQ ID NO:144), or SEQ ID NO:147 (encoded by the nucleotide sequence set forth in SEQ ID NO:146). 
     In some aspects, the polypeptide capable of debranching glycogen comprises a polypeptide having the amino acid sequence set forth in SEQ ID NO:157 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:156). 
     In some aspects, the polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen comprises a polypeptide having the amino acid sequence set forth in SEQ ID NO:159 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:158). 
     In some aspects, the polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate comprises a polypeptide having the amino acid sequence set forth in SEQ ID NO:121 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:120), SEQ ID NO:125 (encoded by the nucleotide sequence set forth in SEQ ID NO:124), SEQ ID NO:127 (encoded by the nucleotide sequence set forth in SEQ ID NO:126), SEQ ID NO:129 (encoded by the nucleotide sequence set forth in SEQ ID NO:128), SEQ ID NO:131 (encoded by the nucleotide sequence set forth in SEQ ID NO:130), SEQ ID NO:133 (encoded by the nucleotide sequence set forth in SEQ ID NO:132), SEQ ID NO:135 (encoded by the nucleotide sequence set forth in SEQ ID NO:134), SEQ ID NO:137 (encoded by the nucleotide sequence set forth in SEQ ID NO:136), or SEQ ID NO:139 (encoded by the nucleotide sequence set forth in SEQ ID NO:138). 
     In some embodiments, a recombinant host comprises a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP and a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate. In some embodiments, a recombinant host comprises a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate. In some embodiments, a recombinant host comprises a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate. In some embodiments, a recombinant host comprises a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate. 
     In some embodiments, a recombinant host comprises a recombinant gene encoding a polypeptide capable of debranching glycogen and a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen. In some embodiments, a recombinant host comprises a recombinant gene encoding a polypeptide capable of debranching glycogen, a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, a polypeptide capable of synthesizing UTP from UDP, and a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate. In some embodiments, a recombinant host comprises a recombinant gene encoding a polypeptide capable of debranching glycogen, a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP, and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate. In some embodiments, a recombinant host comprises a recombinant gene encoding a polypeptide capable of debranching glycogen, a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate. In some embodiments, a recombinant host comprises a recombinant gene encoding a polypeptide capable of debranching glycogen, a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate. 
     In some embodiments, a recombinant host comprises two or more recombinant genes encoding a polypeptide involved in the UDP-glucose biosynthetic pathway, e.g., a gene encoding a polypeptide capable of converting glucose-6-phosphate having a first amino acid sequence and a gene encoding a polypeptide capable of converting glucose-6-phosphate having a second amino acid sequence distinct from the first amino acid sequence. For example, in some embodiments, a recombinant host comprises a gene encoding a polypeptide having the amino acid sequence of PGM1 (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2) and a gene encoding a polypeptide having the amino acid sequence of PGM2 (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, or SEQ ID NO:147). In certain such embodiments, the two or more genes encoding a polypeptide involved in the UDP-glucose biosynthetic pathway comprise nucleotide sequences native to the recombinant host cell (e.g., a recombinant  S. cerevisiae  host cell comprising a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:2 and a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:119). In other such embodiments, one of the two or more genes encoding a polypeptide involved in the UDP-glucose biosynthetic pathway comprises a nucleotide sequence native to the recombinant host cell, while one or more of the two or more genes encoding a polypeptide involved in the UDP-glucose biosynthetic pathway comprises a heterologous nucleotide sequence. For example, in some embodiments, a recombinant  S. cerevisiae  host cell expressing a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:121 (i.e., a recombinant host overexpressing the polypeptide) further expresses a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate having the amino acid sequence set forth in, e.g., SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, or SEQ ID NO:139. In another example, in some embodiments, a recombinant  S. cerevisiae  host cell expressing a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:119 (i.e., a recombinant host overexpressing the polypeptide) further expresses a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate having the amino acid sequence set forth in, e.g., SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, or SEQ ID NO:147. Accordingly, as used herein, the term “a recombinant gene” may include “one or more recombinant genes.” 
     In some embodiments, a recombinant host comprises two or more copies of a recombinant gene encoding a polypeptide involved in the UDP-glucose biosynthetic pathway or the steviol glycoside biosynthetic pathway. In some embodiments, a recombinant host is preferably transformed with, e.g., two copies, three copies, four copies, or five copies of a recombinant gene encoding a polypeptide involved in the UDP-glucose biosynthetic pathway or the steviol glycoside biosynthetic pathway. For example, in some embodiments, a recombinant host is transformed with two copies of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), two copies of a recombinant gene encoding a polypeptide capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), or two copies of a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159). The person of ordinary skill in the art will appreciate that, in some embodiments, recombinant genes may be replicated in a host cell independently of cell replication; accordingly, a recombinant host cell may comprise, e.g., more copies of a recombinant gene than the number of copies the cell was transformed with. Accordingly, as used herein, the term “a recombinant gene” may include “one or more copies of a recombinant gene.” 
     In some aspects, expression of a polypeptide capable of synthesizing UTP from UDP, a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, a polypeptide capable of debranching glycogen, a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and/or a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate in a recombinant host cell increases the amount of UDP-glucose produced by the cell. In some aspects, expression of a polypeptide capable of synthesizing UTP from UDP, a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, a polypeptide capable of debranching glycogen, a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and/or a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate in a recombinant host cell maintains, or even increases, the pool of UDP-glucose available for, e.g., glycosylation of a steviol or a steviol glycoside. In some aspects, expression of a polypeptide capable of synthesizing UTP from UDP, a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, a polypeptide capable of debranching glycogen, a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and/or a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate in a recombinant host cell increases the speed with which UDP-glucose is regenerated, thus maintaining, or even increasing, the UDP-glucose pool, which can be used to synthesize one or more steviol glycosides. 
     In some embodiments, expression of a recombinant gene encoding a polypeptide capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157) and a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159) in a recombinant host cell increases the amount of UDP-glucose produced by the cell by at least 10%, e.g., at least 25%, or at least 50%, or at least 75%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200%, or at least 225%, or at least 250%, or at least 275%, or at least 300%, calculated as an increase in intracellular UDP-glucose concentration relative to a corresponding host lacking the recombinant genes. 
     In some embodiments, expression of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g. a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, or SEQ ID NO:147), a recombinant gene encoding a polypeptide capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, or SEQ ID NO:139) in a recombinant host cell increases the amount of UDP-glucose produced by the cell by at least 10%, e.g., at least 25%, or at least 50%, or at least 75%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200%, or at least 225%, or at least 250%, or at least 275%, or at least 300%, calculated as an increase in intracellular UDP-glucose concentration relative to a corresponding host lacking the recombinant genes. 
     In certain such embodiments, one or more of the recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP, the recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, the recombinant gene encoding a polypeptide capable of debranching glycogen, the recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and the recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate comprise a nucleotide sequence native to the host cell. For example, in some embodiments, expression of a recombinant gene encoding a polypeptide capable of debranching glycogen having the amino acid sequence set forth in SEQ ID NO:157 and a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen having the amino acid sequence set forth in SEQ ID NO:159 in a steviol glycoside-producing  S. cerevisiae  host cell (i.e., providing a recombinant host overexpressing the polypeptides) increases the amount of UDP-glucose produced by the cell by at least 10%, e.g., at least 25%, or at least 50%, or at least 75%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200%, or at least 225%, or at least 250%, or at least 275%, or at least 300%, calculated as an increase in intracellular UDP-glucose concentration relative to a corresponding host lacking the recombinant genes. 
     In another example, in some embodiments, expression of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP having the amino acid sequence set forth in SEQ ID NO:123, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:2 and/or SEQ ID NO:119, a recombinant gene encoding a polypeptide capable of debranching glycogen having the amino acid sequence set forth in SEQ ID NO:157, a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen having the amino acid sequence set forth in SEQ ID NO:159, and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:121 in a steviol glycoside-producing  S. cerevisiae  host cell (i.e., providing a recombinant host overexpressing the polypeptides) increases the amount of UDP-glucose produced by the cell by at least 10%, e.g., at least 25%, or at least 50%, or at least 75%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200%, or at least 225%, or at least 250%, or at least 275%, or at least 300%, calculated as an increase in intracellular UDP-glucose concentration relative to a corresponding host lacking the recombinant genes. 
     In some aspects, expression of a polypeptide capable of synthesizing UTP from UDP, a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, a polypeptide capable of debranching glycogen, a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and/or a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate in a steviol-glycoside producing recombinant host cell further expressing a gene encoding a polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-13 hydroxyl group; a gene encoding a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group; and/or a gene encoding a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside, increases the amount of one or more steviol glycosides produced by the cell, and/or decreases the amount of one or more steviol glycosides produced by the cell. In some embodiments, the steviol glycoside-producing host further expresses a gene encoding a polypeptide capable of synthesizing GGPP from FPP and IPP; a gene encoding a polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP; a gene encoding a polypeptide capable of synthesizing ent-kaurene from ent-copalyl diphosphate; a gene encoding a polypeptide capable of synthesizing ent-kaurenoic acid, ent-kaurenol, and/or ent-kaurenal from ent-kaurene; a gene encoding a polypeptide capable of reducing cytochrome P450 complex; and a gene encoding a polypeptide capable of synthesizing steviol from ent-kaurenoic acid; and/or a gene encoding a bifunctional polypeptide capable of synthesizing ent-copalyldiphosphate from GGPP and synthesizing ent-kaurene from ent-copalyl diphosphate. 
     In some aspects, the polypeptide capable of synthesizing geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP) comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:20 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:19), SEQ ID NO:22 (encoded by the nucleotide sequence set forth in SEQ ID NO:21), SEQ ID NO:24 (encoded by the nucleotide sequence set forth in SEQ ID NO:23), SEQ ID NO:26 (encoded by the nucleotide sequence set forth in SEQ ID NO:25), SEQ ID NO:28 (encoded by the nucleotide sequence set forth in SEQ ID NO:27), SEQ ID NO:30 (encoded by the nucleotide sequence set forth in SEQ ID NO:29), SEQ ID NO:32 (encoded by the nucleotide sequence set forth in SEQ ID NO:31), or SEQ ID NO:116 (encoded by the nucleotide sequence set forth in SEQ ID NO:115). In some embodiments, a recombinant host comprising a gene encoding a polypeptide capable of synthesizing geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP) further comprises one or more genes encoding one or more polypeptides capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147), one or more genes encoding one or more polypeptides capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139). In some embodiments, the recombinant host is an  S. cerevisiae  host cell overexpressing one or more genes encoding one or more polypeptides involved in the UDP-glucose biosynthetic pathway (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:121, SEQ ID NO:123, SEQ ID NO:157, and/or SEQ ID NO:159). 
     In some aspects, the polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:34 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:33), SEQ ID NO:36 (encoded by the nucleotide sequence set forth in SEQ ID NO:35), SEQ ID NO:38 (encoded by the nucleotide sequence set forth in SEQ ID NO:37), SEQ ID NO:40 (encoded by the nucleotide sequence set forth in SEQ ID NO:39), or SEQ ID NO:42 (encoded by the nucleotide sequence set forth in SEQ ID NO:41). In some embodiments, the polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP lacks a chloroplast transit peptide. In some embodiments, a recombinant host comprising a gene encoding a polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP further comprises one or more genes encoding one or more polypeptides capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147), one or more genes encoding one or more polypeptides capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139). In some embodiments, the recombinant host is an  S. cerevisiae  host cell overexpressing one or more genes encoding one or more polypeptides involved in the UDP-glucose biosynthetic pathway (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:121, SEQ ID NO:123, SEQ ID NO:157, and/or SEQ ID NO:159). 
     In some aspects, the polypeptide capable of synthesizing ent-kaurene from ent-copalyl diphosphate comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:44 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:43), SEQ ID NO:46 (encoded by the nucleotide sequence set forth in SEQ ID NO:45), SEQ ID NO:48 (encoded by the nucleotide sequence set forth in SEQ ID NO:47), SEQ ID NO:50 (encoded by the nucleotide sequence set forth in SEQ ID NO:49), or SEQ ID NO:52 (encoded by the nucleotide sequence set forth in SEQ ID NO:51). In some embodiments, a recombinant host comprising a gene encoding a polypeptide capable of synthesizing ent-kaurene from ent-copalyl diphosphate further comprises one or more genes encoding one or more polypeptides capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147), one or more genes encoding one or more polypeptides capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139). In some embodiments, the recombinant host is an  S. cerevisiae  host cell overexpressing one or more genes encoding one or more polypeptides involved in the UDP-glucose biosynthetic pathway (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:121, SEQ ID NO:123, SEQ ID NO:157, and/or SEQ ID NO:159). 
     In some embodiments, a recombinant host comprises a gene encoding a bifunctional polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP and synthesizing ent-kaurene from ent-copalyl diphosphate. In some aspects, the bifunctional polypeptide comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:54 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:53), SEQ ID NO:56 (encoded by the nucleotide sequence set forth in SEQ ID NO:55), or SEQ ID NO:58 (encoded by the nucleotide sequence set forth in SEQ ID NO:57). In some embodiments, a recombinant host comprising a gene encoding a bifunctional polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP and synthesizing ent-kaurene from ent-copalyl diphosphate further comprises one or more genes encoding one or more polypeptides capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147), one or more genes encoding one or more polypeptides capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139). In some embodiments, the recombinant host is an  S. cerevisiae  host cell overexpressing one or more genes encoding one or more polypeptides involved in the UDP-glucose biosynthetic pathway (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:121, SEQ ID NO:123, SEQ ID NO:157, and/or SEQ ID NO:159). 
     In some aspects, the polypeptide capable of synthesizing ent-kaurenoic acid, ent-kaurenol, and/or ent-kaurenal from ent-kaurene comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:60 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:59), SEQ ID NO:62 (encoded by the nucleotide sequence set forth in SEQ ID NO:61), SEQ ID NO:117 (encoded by the nucleotide sequence set forth in SEQ ID NO:63 or SEQ ID NO:64), SEQ ID NO:66 (encoded by the nucleotide sequence set forth in SEQ ID NO:65), SEQ ID NO:68 (encoded by the nucleotide sequence set forth in SEQ ID NO:67), SEQ ID NO:70 (encoded by the nucleotide sequence set forth in SEQ ID NO:69), SEQ ID NO:72 (encoded by the nucleotide sequence set forth in SEQ ID NO:71), SEQ ID NO:74 (encoded by the nucleotide sequence set forth in SEQ ID NO:73), or SEQ ID NO:76 (encoded by the nucleotide sequence set forth in SEQ ID NO:75). In some embodiments, a recombinant host comprising a gene encoding a polypeptide capable of synthesizing ent-kaurenoic acid, ent-kaurenol, and/or ent-kaurenal from ent-kaurene further comprises one or more genes encoding one or more polypeptides capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147), one or more genes encoding one or more polypeptides capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139). In some embodiments, the recombinant host is an  S. cerevisiae  host cell overexpressing one or more genes encoding one or more polypeptides involved in the UDP-glucose biosynthetic pathway (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:121, SEQ ID NO:123, SEQ ID NO:157, and/or SEQ ID NO:159). 
     In some aspects, the polypeptide capable of reducing cytochrome P450 complex comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:78 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:77), SEQ ID NO:80 (encoded by the nucleotide sequence set forth in SEQ ID NO:79), SEQ ID NO:82 (encoded by the nucleotide sequence set forth in SEQ ID NO:81), SEQ ID NO:84 (encoded by the nucleotide sequence set forth in SEQ ID NO:83), SEQ ID NO:86 (encoded by the nucleotide sequence set forth in SEQ ID NO:85), SEQ ID NO:88 (encoded by the nucleotide sequence set forth in SEQ ID NO:87), SEQ ID NO:90 (encoded by the nucleotide sequence set forth in SEQ ID NO:89), or SEQ ID NO:92 (encoded by the nucleotide sequence set forth in SEQ ID NO:91). In some embodiments, a recombinant host comprising a gene encoding a polypeptide capable of reducing cytochrome P450 complex further comprises one or more genes encoding one or more polypeptides capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147), one or more genes encoding one or more polypeptides capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139). In some embodiments, the recombinant host is an  S. cerevisiae  host cell overexpressing one or more genes encoding one or more polypeptides involved in the UDP-glucose biosynthetic pathway (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:121, SEQ ID NO:123, SEQ ID NO:157, and/or SEQ ID NO:159). 
     In some aspects, the polypeptide capable of synthesizing steviol from ent-kaurenoic acid comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:94 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:93), SEQ ID NO:97 (encoded by the nucleotide sequence set forth in SEQ ID NO:95 or SEQ ID NO:96), SEQ ID NO:100 (encoded by the nucleotide sequence set forth in SEQ ID NO:98 or SEQ ID NO:99), SEQ ID NO:101, SEQ ID NO:102, SEQ ID NO:103, SEQ ID NO:104, SEQ ID NO:106 (encoded by the nucleotide sequence set forth in SEQ ID NO:105), SEQ ID NO:108 (encoded by the nucleotide sequence set forth in SEQ ID NO:107), SEQ ID NO:110 (encoded by the nucleotide sequence set forth in SEQ ID NO:109), SEQ ID NO:112 (encoded by the nucleotide sequence set forth in SEQ ID NO:111), or SEQ ID NO:114 (encoded by the nucleotide sequence set forth in SEQ ID NO:113). In some embodiments, a recombinant host comprising a gene encoding a polypeptide capable of synthesizing steviol from ent-kaurenoic acid further comprises one or more genes encoding one or more polypeptides capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147), one or more genes encoding one or more polypeptides capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139). In some embodiments, the recombinant host is an  S. cerevisiae  host cell overexpressing one or more genes encoding one or more polypeptides involved in the UDP-glucose biosynthetic pathway (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:121, SEQ ID NO:123, SEQ ID NO:157, and/or SEQ ID NO:159). 
     In some embodiments, a recombinant host comprises a nucleic acid encoding a polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-13 hydroxyl group (e.g., UGT85C2 polypeptide) (SEQ ID NO:7), a nucleic acid encoding a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside (e.g., UGT76G1 polypeptide) (SEQ ID NO:9), a nucleic acid encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group (e.g., UGT74G1 polypeptide) (SEQ ID NO:4), a nucleic acid encoding a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside (e.g., EUGT11 polypeptide) (SEQ ID NO:16). In some aspects, the polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside (e.g., UGT91D2 polypeptide) can be a UGT91D2e polypeptide (SEQ ID NO:11) or a UGT91D2e-b polypeptide (SEQ ID NO:13). In some embodiments, a recombinant host comprising a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside further comprises one or more genes encoding one or more polypeptides capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147), one or more genes encoding one or more polypeptides capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139). In some embodiments, the recombinant host is an  S. cerevisiae  host cell overexpressing one or more genes encoding one or more polypeptides involved in the UDP-glucose biosynthetic pathway (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:121, SEQ ID NO:123, SEQ ID NO:157, and/or SEQ ID NO:159). 
     In some aspects, the polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-13 hydroxyl group is encoded by the nucleotide sequence set forth in SEQ ID NO:5 or SEQ ID NO:6, the polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside is encoded by the nucleotide sequence set forth in SEQ ID NO:8, the polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group is encoded by the nucleotide sequence set forth in SEQ ID NO:3, the polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside is encoded by the nucleotide sequence set forth in SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, or SEQ ID NO:15. The skilled worker will appreciate that expression of these genes may be necessary to produce a particular steviol glycoside but that one or more of these genes can be endogenous to the host provided that at least one (and in some embodiments, all) of these genes is a recombinant gene introduced into the recombinant host. 
     In some embodiments, expression of a recombinant gene encoding a polypeptide capable of debranching glycogen and a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen in a steviol glycoside-producing recombinant host increases the amount of one or more steviol glycosides, e.g., RebA, RebD, and/or RebM, produced by the cell by at least 10%, at least 25%, or at least 50%, at least 100%, at least 150%, at least 200%, or at least 250%, calculated as an increase in intracellular steviol glycoside concentration relative to a corresponding host lacking the one or more recombinant genes. 
     For example, in some embodiments, expression of a recombinant gene encoding a polypeptide capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157) and a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159) in a steviol glycoside-producing host increases the amount of one or more steviol glycosides, e.g., RebA, RebD, and/or RebM, produced by the cell by at least 10%, at least 25%, or at least 50%, at least 100%, at least 150%, at least 200%, or at least 250%, calculated as an increase in intracellular steviol glycoside concentration relative to a corresponding host lacking the one or more recombinant genes. 
     In some embodiments, expression of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, a recombinant gene encoding a polypeptide capable of debranching glycogen, a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate in a steviol glycoside-producing recombinant host increases the amount of one or more steviol glycosides, e.g., rubusoside, RebB, RebA, RebD, and/or RebM, produced by the cell by at least 10%, at least 25%, or at least 50%, at least 100%, at least 150%, at least 200%, or at least 250%, calculated as an increase in intracellular steviol glycoside concentration relative to a corresponding host lacking the one or more recombinant genes. 
     For example, in some embodiments, expression of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g. a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, or SEQ ID NO:147), a recombinant gene encoding a polypeptide capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, or SEQ ID NO:139) in a steviol glycoside-producing host increases the amount of one or more steviol glycosides, e.g., rubusoside, RebB, RebA, RebD, and/or RebM, produced by the cell by at least 10%, at least 25%, or at least 50%, at least 100%, at least 150%, at least 200%, or at least 250%, calculated as an increase in intracellular steviol glycoside concentration relative to a corresponding host lacking the one or more recombinant genes. 
     In some embodiments, expression of a recombinant gene encoding a recombinant gene encoding a polypeptide capable of debranching glycogen and a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen in a steviol glycoside-producing recombinant host decreases the amount of one or more steviol glycosides, e.g., 13-SMG, produced by the cell by at least 5%, e.g., at least 10%, or at least 15%, or at least 20%, or at least 25%, calculated as a decrease in intracellular steviol glycoside concentration relative to a corresponding steviol glycoside-producing host lacking the recombinant genes. 
     For example, in some embodiments, expression of a recombinant gene encoding a polypeptide capable of debranching glycogen having the amino acid sequence set forth in SEQ ID NO:157 and a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen having the amino acid sequence set forth in SEQ ID NO:159 in a steviol glycoside-producing recombinant host decreases the amount of 13-SMG produced by the cell by at least 5%, e.g., at least 7.5%, or at least 10%, or at least 15%, or at least 20%, at least 25%, or at least 50%, calculated as decrease in intracellular 13-SMG concentration relative to a corresponding host lacking the one or more recombinant genes. 
     In some embodiments, expression of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, a recombinant gene encoding a polypeptide capable of debranching glycogen, a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate in a steviol glycoside-producing recombinant host decreases the amount of one or more steviol glycosides, e.g., 13-SMG and RebD, produced by the cell by at least 5%, e.g., at least 10%, or at least 15%, or at least 20%, or at least 25%, or at least 30%, or at least 35%, or at least 40%, or at least 45%, or at least 50%, calculated as a decrease in intracellular steviol glycoside concentration relative to a corresponding steviol glycoside-producing host lacking the recombinant genes. 
     For example, in some embodiments, expression of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP having the amino acid sequence set forth in SEQ ID NO:123, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:2, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:119, a recombinant gene encoding a polypeptide capable of debranching glycogen having the amino acid sequence set forth in SEQ ID NO:157, a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen having the amino acid sequence set forth in SEQ ID NO:159, a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:121, and further expression of a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate having the amino acid sequence set forth in, e.g., SEQ ID NO:127, SEQ ID NO:133, SEQ ID NO:129, SEQ ID NO:125, SEQ ID NO:139, or SEQ ID NO:135, in a steviol glycoside-producing recombinant host decreases the amount of 13-SMG produced by the cell by at least 5%, e.g., at least 7.5%, or at least 10%, or at least 15%, or at least 20%, or at least 25%, or at least 30%, at least 35%, or at least 50%, calculated as a decrease in intracellular 13-SMG concentration relative to a corresponding host lacking the one or more recombinant genes. 
     In some embodiments, expression of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, a recombinant gene encoding a polypeptide capable of debranching glycogen, a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate in a steviol glycoside-producing recombinant host increases the total amount of steviol glycosides (i.e., the total amount of mono-, di-, tri-, tetra-penta-, hexa-, and hepta-glycosylated steviol compounds) by at least 5%, e.g., at least 7.5%, or at least 10%, or at least 12.5%, or at least 15%, or at least 17.5%, or at least 20%, or at least 25%, or at least 27.5%, or at least 30%, or at least 35%, calculated as an increase in intracellular steviol glycoside concentration relative to a corresponding steviol glycoside-producing host lacking the recombinant genes. 
     For example, in some embodiments, expression of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP having the amino acid sequence set forth in SEQ ID NO:123, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:2, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:119, a recombinant gene encoding a polypeptide capable of debranching glycogen having the amino acid sequence set forth in SEQ ID NO:157, a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen having the amino acid sequence set forth in SEQ ID NO:159, a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:121, and further expression of a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate having the amino acid sequence set forth in, e.g., SEQ ID NO:133, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:125, SEQ ID NO:139, or SEQ ID NO:135, in a steviol glycoside-producing recombinant host increases the total amount of steviol glycosides (i.e., the total amount of mono-, di-, tri-, tetra-penta-, hexa-, and hepta-glycosylated steviol compounds) by at least 5%, e.g., at least 7.5%, or at least 10%, or at least 12.5%, or at least 15%, or at least 17.5%, or at least 20%, or at least 25%, or at least 27.5%, or at least 30%, or at least 35%, calculated as an increase in intracellular steviol glycoside concentration relative to a corresponding steviol glycoside-producing host lacking the recombinant genes. 
     In some other embodiments, the total amount of steviol glycosides produced by a steviol glycoside-producing recombinant host cell is unchanged (i.e., increased or decreased by less than 5%, or less than 4%, or less than 3%, or less than 2%, or less than 1%) by expression in the host of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, a recombinant gene encoding a polypeptide capable of debranching glycogen, a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and/or a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate. 
     For example, in some embodiments, expression of a recombinant gene encoding a polypeptide capable of debranching glycogen having the amino acid sequence set forth in SEQ ID NO:157 and a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen having the amino acid sequence set forth in SEQ ID NO:159 in a steviol glycoside-producing recombinant host increases the total amount of steviol glycosides produced by the host by less than 5%, e.g., less than 4%, or less than 3%, or less than 2%. 
     In another example, in some embodiments, expression of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP having the amino acid sequence set forth in SEQ ID NO:123, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:2, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:119, a recombinant gene encoding a polypeptide capable of debranching glycogen having the amino acid sequence set forth in SEQ ID NO:157, a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen having the amino acid sequence set forth in SEQ ID NO:159, and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:121 in a steviol glycoside-producing recombinant host increases the total amount of steviol glycosides produced by the host by less than 5%, e.g., less than 4%, or less than 3%, or less than 2%. 
     The person of ordinary skill in the art will appreciate that, in such embodiments, expression of one or more genes encoding a polypeptide involved in the involved in the UDP-glucose biosynthetic pathway may affect the relative levels of steviol glycosides produced by the recombinant host, e.g., by increasing the level of UDP-glucose available as a substrate for a polypeptide capable of glycosylating a steviol or a steviol glycoside. 
     For example, in some embodiments, expression of a recombinant gene encoding a polypeptide capable of debranching glycogen having the amino acid sequence set forth in SEQ ID NO:157 and a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen having the amino acid sequence set forth in SEQ ID NO:159 in a steviol glycoside-producing recombinant host increases the total amount of steviol glycosides produced by the host by less than 5%, e.g., less than 4%, or less than 3%, or less than 2%, increases the amount of RebA, RebD, and/or RebM produced by the host by at least 10%, at least 25%, or at least 50%, at least 100%, at least 150%, at least 200%, or at least 250%, calculated as an increase in intracellular steviol glycoside concentration relative to a corresponding host lacking the one or more recombinant genes and decreases the amount of 13-SMG produced by the host cell by at least 5%, e.g., at least 10%, at least 20%, at least 25%, or at least 50%, calculated as a decrease in intracellular 13-SMG concentration relative to a corresponding host lacking the one or more recombinant genes. 
     In another example, in some embodiments, expression of a recombinant gene encoding a polypeptide capable of synthesizing UTP from UDP having the amino acid sequence set forth in SEQ ID NO:123, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:2, a recombinant gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:119, a recombinant gene encoding a polypeptide capable of debranching glycogen having the amino acid sequence set forth in SEQ ID NO:157, a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen having the amino acid sequence set forth in SEQ ID NO:159, and a recombinant gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate having the amino acid sequence set forth in SEQ ID NO:121 in a steviol glycoside-producing recombinant host increases the total amount of steviol glycosides produced by the host by less than 5%, e.g., less than 4%, or less than 3%, or less than 2%, increases the amount of RebM produced by the host by at least 10%, at least 25%, or at least 50%, at least 100%, at least 150%, at least 200%, or at least 250%, calculated as an increase in intracellular RebM concentration relative to a corresponding host lacking the one or more recombinant genes, and decreases the amount of RebD produced by the host by at least 10%, e.g., at least 20%, or at least 30%, at least 40%, or at least 50%, calculated as a decrease in intracellular RebD concentration relative to a corresponding host lacking the one or more recombinant genes. 
     In some embodiments, a recombinant host cell comprises one or more genes encoding one or more polypeptides capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157) and/or one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159). In some embodiments, a recombinant host cell comprises one or more genes encoding one or more polypeptides capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147), one or more genes encoding one or more polypeptides capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139). 
     In certain embodiments, a recombinant host comprises one or more recombinant genes having a nucleotide sequence native to the host that encode one or more polypeptides capable of synthesizing UTP from UDP, one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate, one or more polypeptides capable of debranching glycogen, one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and/or one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate, i.e., a recombinant host overexpresses one or more polypeptides capable of synthesizing UTP from UDP, one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate, one or more polypeptides capable of debranching glycogen, one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and/or one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate. 
     In certain such embodiments, a recombinant host cell overexpresses one or more genes encoding one or more polypeptides capable of synthesizing UTP from UDP (e.g., an  S. cerevisiae  host cell expressing a recombinant gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., an  S. cerevisiae  host cell expressing a recombinant gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, and/or SEQ ID NO:119), one or more genes encoding one or more polypeptides capable of debranching glycogen (e.g., an  S. cerevisiae  host cell expressing a recombinant gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., an  S. cerevisiae  host cell expressing a recombinant gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., an  S. cerevisiae  host cell expressing a recombinant gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:121). 
     In one example, a recombinant  S. cerevisiae  host cell overexpresses a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:157 and a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:159. In another example, a recombinant  S. cerevisiae  host cell overexpresses a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:123, a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:119, a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:157, and a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:159. 
     In certain embodiments, a recombinant host cell comprising one or more genes encoding one or more polypeptides capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147), one or more genes encoding one or more polypeptides capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), one or more genes encoding one or more polypeptides capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139), further comprises a gene encoding a polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-13 hydroxyl group (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:7); a gene encoding a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:9); a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:4); and/or a gene encoding a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:11, SEQ ID NO:13, or SEQ ID NO:16). In certain such embodiments, the recombinant host cell further comprises a gene encoding a polypeptide capable of synthesizing GGPP from FPP and IPP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:20); a gene encoding a polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:40); a gene encoding a polypeptide capable of synthesizing ent-kaurene from ent-copalyl diphosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:52); a gene encoding a polypeptide capable of synthesizing ent-kaurenoic acid, ent-kaurenol, and/or ent-kaurenal from ent-kaurene (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:60 or SEQ ID NO:117); a gene encoding a polypeptide capable of reducing cytochrome P450 complex (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:78, SEQ ID NO:86, or SEQ ID NO:92); and/or a gene encoding a polypeptide capable of synthesizing steviol from ent-kaurenoic acid (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:94). 
     In some embodiments, a recombinant host comprises two or more genes encoding two or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., two or more polypeptides having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147), and/or two or more genes encoding two or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., two or more polypeptides having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139). 
     In certain such embodiments, a recombinant host comprises two or more genes encoding two or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate, e.g., two or more genes encoding two or more polypeptides having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147. In one example, a recombinant host comprises a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:2 and a polypeptide having the amino acid sequence set forth in SEQ ID NO:119. In another example, a recombinant host comprises a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:2, a polypeptide having the amino acid sequence set forth in SEQ ID NO:119, and a polypeptide having the amino acid sequence set forth in SEQ ID NO:145. In some embodiments, the recombinant host further comprises a gene encoding a polypeptide capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), a gene encoding a polypeptide capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), a gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and/or one or more genes encoding one or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139). 
     In certain such embodiments, a recombinant host comprises two or more genes encoding two or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate, e.g., two or more genes encoding two or more polypeptides having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139. In one example, a recombinant host comprises a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:121 and a polypeptide having the amino acid sequence set forth in SEQ ID NO:125. In another example, a recombinant host comprises a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:121 and a polypeptide having the amino acid sequence set forth in SEQ ID NO:127. In another example, a recombinant host comprises a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:121 and a polypeptide having the amino acid sequence set forth in SEQ ID NO:129. In another example, a recombinant host comprises a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:121 and a polypeptide having the amino acid sequence set forth in SEQ ID NO:131. In another example, a recombinant host comprises a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:121 and a gene encoding a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:133. In another example, a recombinant host comprises a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:121 and a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:135. In another example, a recombinant host comprises a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:121 and a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:137. In another example, a recombinant host comprises a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:121 and a gene encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO:139. In some embodiments, the recombinant host further comprises a gene encoding a polypeptide capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), a gene encoding a polypeptide capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), a gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), and/or one or more genes encoding one or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., one or more polypeptides having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147). 
     In certain such embodiments, a recombinant host comprising two or more genes encoding two or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., two or more polypeptides having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147), and/or two or more genes encoding two or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., two or more polypeptides having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139) is a host cell overexpressing one or more genes encoding one or more polypeptides involved in the UDP-glucose biosynthetic pathway (e.g., an  S. cerevisiae  host cell expressing one or more genes encoding one or more polypeptides having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:121, SEQ ID NO:123, SEQ ID NO:157, and/or SEQ ID NO:159). 
     In certain embodiments, a recombinant host cell comprising two or more genes encoding two or more polypeptides capable of converting glucose-6-phosphate to glucose-1-phosphate (e.g., two or more polypeptides having the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:119, SEQ ID NO:141, SEQ ID NO:143, SEQ ID NO:145, and/or SEQ ID NO:147), and/or two or more genes encoding two or more polypeptides capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate (e.g., two or more polypeptides having the amino acid sequence set forth in SEQ ID NO:121, SEQ ID NO:125, SEQ ID NO:127, SEQ ID NO:129, SEQ ID NO:131, SEQ ID NO:133, SEQ ID NO:135, SEQ ID NO:137, and/or SEQ ID NO:139), further comprises a gene encoding polypeptide capable of synthesizing UTP from UDP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:123), a gene encoding a polypeptide capable of debranching glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:157), a gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:159), a gene encoding a polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-13 hydroxyl group (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:7); a gene encoding a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:9); a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:4); and/or a gene encoding a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:11, SEQ ID NO:13, or SEQ ID NO:16). In certain such embodiments, the recombinant host cell further comprises a gene encoding a polypeptide capable of synthesizing GGPP from FPP and IPP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:20); a gene encoding a polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:40); a gene encoding a polypeptide capable of synthesizing ent-kaurene from ent-copalyl diphosphate (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:52); a gene encoding a polypeptide capable of synthesizing ent-kaurenoic acid, ent-kaurenol, and/or ent-kaurenal from ent-kaurene (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:60 or SEQ ID NO:117); a gene encoding a polypeptide capable of reducing cytochrome P450 complex (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:78, SEQ ID NO:86, or SEQ ID NO:92); and/or a gene encoding a polypeptide capable of synthesizing steviol from ent-kaurenoic acid (e.g., a polypeptide having the amino acid sequence set forth in SEQ ID NO:94). 
     In some embodiments, one or more steviol glycosides or a steviol glycoside composition is produced in an in vitro method, comprising adding a polypeptide capable of debranching glycogen comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:157 and/or a polypeptide capable of synthesizing glucose-1-phosphate comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:159; and, optionally, one or more of: a polypeptide capable of synthesizing UTP from UDP comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:123; a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:2, 119, or 143 or a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:141, 145, or 147; and/or a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:121 or 127, a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:125, 129, 133, 135, 137, or 139 or a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in SEQ ID NO:131; and one or more of: a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-13 hydroxyl group thereof comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:7; a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside comprises a polypeptide having at least 50% sequence identity to the amino acid sequence set forth in SEQ ID NO:9; a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:4; a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside comprises a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:11; a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:13; or a polypeptide having at least 65% sequence identity to the amino acid sequence set forth in SEQ ID NO:16; and a plant-derived or synthetic steviol, steviol precursors, and/or steviol glycosides to a reaction mixture; wherein at least one of the polypeptide is a recombinant polypeptide; and producing the one or more steviol glycosides or the steviol glycoside composition thereby. 
     In one aspect of the in vitro methods disclosed herein, the reaction mixture comprises: (a) one or more steviol glycosides or steviol glycoside composition; (b) a polypeptide capable of debranching glycogen having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:157 and/or a polypeptide capable of synthesizing glucose-1-phosphate comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:159; and, optionally, one or more of: a polypeptide capable of synthesizing UTP from UDP comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:123; a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:2, 119, or 143 or a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:141, 145, or 147; and/or a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:121 or 127, a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:125, 129, 133, 135, 137, or 139 or a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in SEQ ID NO:131; and one or more of: a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-13 hydroxyl group thereof comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:7; a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside comprises a polypeptide having at least 50% sequence identity to the amino acid sequence set forth in SEQ ID NO:9; a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:4; a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside comprises a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:11; a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:13; or a polypeptide having at least 65% sequence identity to the amino acid sequence set forth in SEQ ID NO:16; (c) uridine diphosphate (UDP)-glucose, UDP-rhamnose, UDP-xylose, and/or N-acetyl-glucosamine ; and/or (d) reaction buffer and/or salts. 
     In one aspect of the in vitro methods disclosed herein, the one or more steviol glycosides is, or the steviol glycoside composition comprises, steviol-13-O-glucoside (13-SMG), steviol-1,2-Bioside, steviol-1,3-Bioside, steviol-19-O-glucoside (19-SMG), 1,2-stevioside, 1,3-stevioside (RebG), rubusoside, rebaudioside A (RebA), rebaudioside B (RebB), rebaudioside C (RebC), rebaudioside D (RebD), rebaudioside E (RebE), rebaudioside F (RebF), rebaudioside M (RebM), rebaudioside Q (RebQ), rebaudioside I (RebI), dulcoside A, and/or an isomer thereof. 
     In some embodiments, one or more steviol glycosides or a steviol glycoside composition is produced by whole cell bioconversion. For whole cell bioconversion to occur, a host cell expressing one or more enzymes involved in the steviol glycoside pathway takes up and modifies a steviol glycoside precursor in the cell; following modification in vivo, a steviol glycoside remains in the cell and/or is excreted into the culture medium. For example, a host cell expressing a gene encoding a polypeptide capable of synthesizing UTP from UDP, a gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, a gene encoding a polypeptide capable of debranching glycogen, a gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and/or a gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate; and further expressing a gene encoding a polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-13 hydroxyl group; a gene encoding a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group; and/or a gene encoding a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside can take up steviol and glycosylate steviol in the cell; following glycosylation in vivo, a steviol glycoside can be excreted into the culture medium. In certain such embodiments, the host cell may further express a gene encoding a polypeptide capable of synthesizing GGPP from FPP and IPP; a gene encoding a polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP; a gene encoding a polypeptide capable of synthesizing ent-kaurene from ent-copalyl diphosphate; a gene encoding a polypeptide capable of synthesizing ent-kaurenoic acid, ent-kaurenol, and/or ent-kaurenal from ent-kaurene; a gene encoding a polypeptide capable of reducing cytochrome P450 complex; a gene encoding a polypeptide capable of synthesizing steviol from ent-kaurenoic acid; and/or a gene encoding a bifunctional polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP and synthesizing ent-kaurene from ent-copalyl diphosphate. 
     In some embodiments, the method for producing one or more steviol glycosides or a steviol glycoside composition disclosed herein comprises whole-cell bioconversion of plant-derived or synthetic steviol and/or steviol glycosides in a cell culture medium of a recombinant host cell using: (a) a polypeptide capable of debranching glycogen, and/or (b) a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen; optionally, one or more of: (c) a polypeptide capable of synthesizing UTP from UDP, (d) a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, and/or (e) a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate; and one or more of: (f) a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-13 hydroxyl group thereof; (g) a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; (h) a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof; and/or (i) a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; wherein at least one of the polypeptides is a recombinant polypeptide expressed in the recombinant host cell; and producing the one or more steviol glycosides or the steviol glycoside composition thereby. 
     In some embodiments of the methods for producing one or more steviol glycosides or a steviol glycoside composition disclosed herein comprises whole-cell bioconversion of plant-derived or synthetic steviol and/or steviol glycosides in a cell culture medium of a recombinant host cell disclosed herein, the polypeptide capable of debranching glycogen comprises a polypeptide having the amino acid sequence set forth in SEQ ID NO:157; and/or the polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen comprises a polypeptide having the amino acid sequence set forth in SEQ ID NO:159. 
     In some embodiments, a polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-13 hydroxyl group thereof; a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof; and/or a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside can be displayed on the surface of the recombinant host cells disclosed herein by fusing it with anchoring motifs. 
     In some embodiments, the cell is permeabilized to take up a substrate to be modified or to excrete a modified product. In some embodiments, a permeabilizing agent can be added to aid the feedstock entering into the host and product getting out. In some embodiments, the cells are permeabilized with a solvent such as toluene, or with a detergent such as Triton-X or Tween. In some embodiments, the cells are permeabilized with a surfactant, for example a cationic surfactant such as cetyltrimethylammonium bromide (CTAB). In some embodiments, the cells are permeabilized with periodic mechanical shock such as electroporation or a slight osmotic shock. For example, a crude lysate of the cultured microorganism can be centrifuged to obtain a supernatant. The resulting supernatant can then be applied to a chromatography column, e.g., a C18 column, and washed with water to remove hydrophilic compounds, followed by elution of the compound(s) of interest with a solvent such as methanol. The compound(s) can then be further purified by preparative HPLC. See also, WO 2009/140394. 
     In some embodiments, steviol, one or more steviol glycoside precursors, one or more steviol glycosides, or a steviol glycoside composition are produced by co-culturing of two or more hosts. In some embodiments, one or more hosts, each expressing one or more enzymes involved in the steviol glycoside pathway, produce steviol, one or more steviol glycoside precursors, and/or one or more steviol glycosides. For example, a host expressing a gene encoding a polypeptide capable of synthesizing GGPP from FPP and IPP; a gene encoding a polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP; a gene encoding a polypeptide capable of synthesizing ent-kaurene from ent-copalyl diphosphate; a gene encoding a polypeptide capable of synthesizing ent-kaurenoic acid, ent-kaurenol, and/or ent-kaurenal from ent-kaurene; a gene encoding a polypeptide capable of reducing cytochrome P450 complex; a gene encoding a polypeptide capable of synthesizing steviol from ent-kaurenoic acid; and/or a gene encoding a bifunctional polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP and synthesizing ent-kaurene from ent-copalyl diphosphate and a host expressing a gene encoding a polypeptide capable of synthesizing UTP from UDP, a gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, a gene encoding a polypeptide capable of debranching glycogen, a gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, and/or a gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate; and further expressing a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-13 hydroxyl group; a gene encoding a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group; and/or a gene encoding a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside, produce one or more steviol glycosides. 
     In some embodiments, the steviol glycoside comprises, for example, but not limited to, 13-SMG, steviol-1,2-bioside, steviol-1,3-bioside, 19-SMG, 1,2-stevioside, 1,3-stevioside (RebG), rubusoside, RebA, RebB, RebC, RebD, RebE, RebF, RebM, RebQ, RebI, dulcoside A, di-glycosylated steviol, tri-glycosylated steviol, tetra-glycosylated steviol, penta-glycosylated steviol, hexa-glycosylated steviol, hepta-glycosylated steviol, or isomers thereof. 
     In some embodiments, a steviol glycoside or steviol glycoside precursor composition produced in vivo, in vitro, or by whole cell bioconversion does not comprise or comprises a reduced amount or reduced level of plant-derived components than a  Stevia  extract from, inter alia, a  Stevia  plant. Plant-derived components can contribute to off-flavors and include pigments, lipids, proteins, phenolics, saccharides, spathulenol and other sesquiterpenes, labdane diterpenes, monoterpenes, decanoic acid, 8,11,14-eicosatrienoic acid, 2-methyloctadecane, pentacosane, octacosane, tetracosane, octadecanol, stigmasterol, β-sitosterol, α- and β-amyrin, lupeol, β-amryin acetate, pentacyclic triterpenes, centauredin, quercitin, epi-alpha-cadinol, carophyllenes and derivatives, beta-pinene, beta-sitosterol, and gibberellin. In some embodiments, the plant-derived components referred to herein are non-glycoside compounds. 
     As used herein, the terms “detectable amount,” “detectable concentration,” “measurable amount,” and “measurable concentration” refer to a level of steviol glycosides measured in AUC, μM/OD 600 , mg/L, μM, or mM. Steviol glycoside production (i.e., total, supernatant, and/or intracellular steviol glycoside levels) can be detected and/or analyzed by techniques generally available to one skilled in the art, for example, but not limited to, liquid chromatography-mass spectrometry (LC-MS), thin layer chromatography (TLC), high-performance liquid chromatography (HPLC), ultraviolet-visible spectroscopy/spectrophotometry (UV-Vis), mass spectrometry (MS), and nuclear magnetic resonance spectroscopy (NMR). 
     As used herein, the term “undetectable concentration” refers to a level of a compound that is too low to be measured and/or analyzed by techniques such as TLC, HPLC, UV-Vis, MS, or NMR. In some embodiments, a compound of an “undetectable concentration” is not present in a steviol glycoside or steviol glycoside precursor composition. 
     After the recombinant microorganism has been grown in culture for the period of time, wherein the temperature and period of time facilitate the production of a steviol glycoside, steviol and/or one or more steviol glycosides can then be recovered from the culture using various techniques known in the art. Steviol glycosides can be isolated using a method described herein. For example, following fermentation, a culture broth can be centrifuged for 30 min at 7000 rpm at 4° C. to remove cells, or cells can be removed by filtration. The cell-free lysate can be obtained, for example, by mechanical disruption or enzymatic disruption of the host cells and additional centrifugation to remove cell debris. Mechanical disruption of the dried broth materials can also be performed, such as by sonication. The dissolved or suspended broth materials can be filtered using a micron or sub-micron prior to further purification, such as by preparative chromatography. The fermentation media or cell-free lysate can optionally be treated to remove low molecular weight compounds such as salt; and can optionally be dried prior to purification and re-dissolved in a mixture of water and solvent. 
     The supernatant or cell-free lysate can be purified as follows: a column can be filled with, for example, HP20 Diaion resin (aromatic type Synthetic Adsorbent; Supelco) or other suitable non-polar adsorbent or reversed-phase chromatography resin, and an aliquot of supernatant or cell-free lysate can be loaded on to the column and washed with water to remove the hydrophilic components. The steviol glycoside product can be eluted by stepwise incremental increases in the solvent concentration in water or a gradient from, e. g., 0%→100% methanol). The levels of steviol glycosides, glycosylated ent-kaurenol, and/or glycosylated ent-kaurenoic acid in each fraction, including the flow-through, can then be analyzed by LC-MS. Fractions can then be combined and reduced in volume using a vacuum evaporator. Additional purification steps can be utilized, if desired, such as additional chromatography steps and crystallization. For example, steviol glycosides can be isolated by methods not limited to ion exchange chromatography, reversed-phase chromatography (i.e., using a C18 column), extraction, crystallization, and carbon columns and/or decoloring steps. 
     In one embodiment, a recombinant host cell capable of producing one or more steviol glycosides or a steviol glycoside composition in a cell culture comprises a recombinant gene encoding a polypeptide capable of debranching glycogen; and/or a recombinant gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, wherein the polypeptide capable of debranching glycogen is capable of 4-α-glucanotransferase activity and α-1,6-amyloglucosidase activity, wherein the recombinant host cell further comprises a gene encoding a polypeptide capable of synthesizing uridine 5′-triphosphate (UTP) from uridine diphosphate (UDP); a gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate; and/or a gene encoding a polypeptide capable of synthesizing uridine diphosphate glucose (UDP-glucose) from UTP and glucose-1-phosphate, wherein: the polypeptide capable of debranching glycogen comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:157; the polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:159; the polypeptide capable of synthesizing UTP from UDP comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:123; the polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in any one of SEQ ID NO:2, 119, or 143 or a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:141, 145, or 147; and/or the polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate comprises a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in any one of SEQ ID NO:121 or 127, a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:125, 129, 133, 135, 137, or 139 or a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in SEQ ID NO:131. 
     In another embodiment, the recombinant host cell discussed above further comprises a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-13 hydroxyl group thereof; a gene encoding a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside; a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof; and/or a gene encoding a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside; and further comprises a gene encoding a polypeptide capable of synthesizing geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP); a gene encoding a polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP; a gene encoding an a polypeptide capable of synthesizing ent-kaurene from ent-copalyl diphosphate; a gene encoding a polypeptide capable of synthesizing ent-kaurenoic acid from ent-kaurene; a gene encoding a polypeptide capable of reducing cytochrome P450 complex; and/or a gene encoding a polypeptide capable of synthesizing steviol from ent-kaurenoic acid, wherein the polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-13 hydroxyl group thereof comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:7; the polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside comprises a polypeptide having at least 50% sequence identity to the amino acid sequence set forth in SEQ ID NO:9; the polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:4; the polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside comprises a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:11; a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:13; or a polypeptide having at least 65% sequence identity to the amino acid sequence set forth in SEQ ID NO:16; the polypeptide capable of synthesizing GGPP comprises a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in any one of SEQ ID NO:20, 22, 24, 26, 28, 30, 32, or 116; the polypeptide capable of synthesizing ent-copalyl diphosphate comprises a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in any one of SEQ ID NO:34, 36, 38, 40, 42, or 120; the polypeptide capable of synthesizing ent-kaurene comprises a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in any one of SEQ ID NO:44, 46, 48, 50, or 52; the polypeptide capable of synthesizing ent-kaurenoic acid comprises a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:60, 62, 117, SEQ ID NO:66, 68, 70, 72, 74, or 76; the polypeptide capable of reducing cytochrome P450 complex comprises a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:78, 80, 82, 84, 86, 88, 90, 92; and/or the polypeptide capable of synthesizing steviol comprises a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:94, 97, 100, 101, 102, 103, 104, 106, 108, 110, 112, or 114. 
     In another embodiment, the recombinant host cell discussed above comprises a gene encoding a polypeptide capable of debranching glycogen having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:157; a gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:159; a gene encoding a polypeptide capable of synthesizing uridine 5′-triphosphate (UTP) from uridine diphosphate (UDP) having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:123; a gene encoding a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate having at least 60% sequence identity to the amino acid sequences set forth in any one of SEQ ID NOs:2 or 119; and a gene encoding a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:121; and one or more of: a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-13 hydroxyl group thereof having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:7; a gene encoding a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside having at least 50% sequence identity to the amino acid sequence set forth in SEQ ID NO:9; a gene encoding a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:4; a gene encoding a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside comprises a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:11; a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:13; or a polypeptide having at least 65% sequence identity to the amino acid sequence set forth in SEQ ID NO:16. 
     In another embodiment, the recombinant host cell discussed above comprises a gene encoding a polypeptide capable of debranching glycogen having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:157; and/or a gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:159; wherein the gene encoding a polypeptide capable of debranching glycogen and/or the gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen are overexpressed relative to a corresponding host cell lacking the one or more recombinant genes, wherein the gene encoding a polypeptide capable of debranching glycogen and/or the gene encoding a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen are overexpressed by at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% relative to a corresponding host cell lacking the one or more recombinant genes. 
     In another embodiment, the expression of the one or more recombinant genes comprising the recombinant host cell increase the amount of UDP-glucose accumulated by the recombinant host cell relative to a corresponding host lacking the one or more recombinant genes, wherein expression of the one or more recombinant genes increases the amount of UDP-glucose accumulated by the cell by at least 10%, at least 25%, or at least 50%, at least 100%, at least 150%, at least 200%, or at least 250% relative to a corresponding host lacking the one or more recombinant genes, wherein expression of the one or more recombinant genes increases an amount of the one or more steviol glycosides or the steviol glycoside composition produced by the cell relative to a corresponding host lacking the one or more recombinant genes, wherein expression of the one or more recombinant genes increases the amount of the one or more steviol glycosides produced by the cell by at least 5%, or at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% relative to a corresponding host cell lacking the one or more recombinant genes, wherein expression of the one or more recombinant genes increases an amount of RebA, RebD, and/or RebM produced by the cell by at least 5%, or at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% relative to a corresponding host cell lacking the one or more recombinant genes, wherein expression of the one or more recombinant genes decreases the amount of the one of one or more steviol glycosides or the steviol glycoside composition accumulated by the cell relative to a corresponding host lacking the one or more recombinant genes, wherein expression of the one or more recombinant genes decreases the amount of the one or more steviol glycosides accumulated by the cell by at least 5%, or at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50% relative to a corresponding host cell lacking the one or more recombinant genes relative to a corresponding host lacking the one or more recombinant genes, wherein expression of the one or more recombinant genes decreases an amount of 13-SMG accumulated by the cell relative to a corresponding host lacking the one or more recombinant genes, wherein expression of the one or more recombinant genes increases the amount of total steviol glycosides produced by the cell by at least 5%, or at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% relative to a corresponding host lacking the one or more recombinant genes, and/or wherein expression of the one or more recombinant genes decreases the amount of total steviol glycosides produced by the cell by less than 10%, or less than 5%, or less than 2.5% relative to a corresponding host lacking the one or more recombinant genes. 
     In one embodiment of the recombinant host cells discussed above, the one or more steviol glycosides is, or the steviol glycoside composition comprises, steviol-13-O-glucoside (13-SMG), steviol-1,2-Bioside, steviol-1,3-Bioside, steviol-19-O-glucoside (19-SMG), 1,2-Stevioside, 1,3-stevioside (RebG), rubusoside, rebaudioside A (RebA), rebaudioside B (RebB), rebaudioside C (RebC), rebaudioside D (RebD), rebaudioside E (RebE), rebaudioside F (RebF), rebaudioside M (RebM), rebaudioside Q (RebQ), rebaudioside I (RebI), dulcoside A, and/or an isomer thereof. 
     In one embodiment of the recombinant host cells discussed above, the recombinant host cell is a plant cell, a mammalian cell, an insect cell, a fungal cell, an algal cell or a bacterial cell. 
     In one embodiment, a method of producing one or more steviol glycosides or a steviol glycoside composition in a cell culture, comprises culturing the recombinant host cells discussed above in the cell culture, under conditions in which the genes are expressed, and wherein the one or more steviol glycosides or the steviol glycoside composition is produced by the recombinant host cells, wherein the genes are constitutively expressed or wherein the expression of the genes is induced, wherein the amount of RebA, RebD, and/or RebM produced by the cell is increased by at least 5%, or at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% relative to a corresponding host lacking the one or more recombinant genes, wherein the amount of 13-SMG accumulated by the cell is decreased by at least 10%, at least 25%, or at least 50% relative to a corresponding host lacking the one or more recombinant genes, wherein the amount of total steviol glycosides produced by the cell is increased by at least 5%, or at least 10%, or at least 15%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or at least 100%, or at least 125%, or at least 150%, or at least 175%, or at least 200% relative to a corresponding host lacking the one or more recombinant genes, wherein the amount of total steviol glycosides produced by the cell decreases the amount of total steviol glycosides produced by the cell by less than 10%, or less than 5%, or less than 2.5% relative to a corresponding host lacking the one or more recombinant genes, wherein the recombinant host cell is grown in a fermentor at a temperature for a period of time, wherein the temperature and period of time facilitate the production of the one or more steviol glycosides or the steviol glycoside composition, and/or wherein the amount of UDP-glucose accumulated by the cell by at least 10%, at least 25%, or at least 50%, at least 100%, at least 150%, at least 200%, or at least 250% relative to a corresponding host lacking the one or more recombinant genes. 
     In one embodiment, the method of producing one or more steviol glycosides or a steviol glycoside composition in a cell culture further comprises isolating the produced one or more steviol glycosides or the steviol glycoside composition from the cell culture, wherein the isolating step comprises separating a liquid phase of the cell culture from a solid phase of the cell culture to obtain a supernatant comprising the produced one or more steviol glycosides or the steviol glycoside composition, and contacting the supernatant with one or more adsorbent resins in order to obtain at least a portion of the produced one or more steviol glycosides or the steviol glycoside composition; or contacting the supernatant with one or more ion exchange or reversed-phase chromatography columns in order to obtain at least a portion of the produced one or more steviol glycosides or the steviol glycoside composition; or crystallizing or extracting the produced one or more steviol glycosides or the steviol glycoside composition; thereby isolating the produced one or more steviol glycosides or the steviol glycoside composition. 
     In one embodiment, the method of producing one or more steviol glycosides or a steviol glycoside composition in a cell culture further comprises recovering the one or more steviol glycosides or the steviol glycoside composition from the cell culture, wherein the produced one or more steviol glycosides or the steviol glycoside composition is enriched for the one or more steviol glycosides relative to a steviol glycoside composition of  Stevia  plant and has a reduced level of  Stevia  plant-derived components relative to a steviol glycoside composition obtained from a plant-derived  Stevia  extract. 
     In one embodiment, the method of producing one or more steviol glycosides or a steviol glycoside composition comprises whole-cell bioconversion of a plant-derived or synthetic steviol and/or steviol glycosides in a cell culture of a recombinant host cell using a polypeptide capable of debranching glycogen, comprising a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:157; and/or a polypeptide capable of synthesizing glucose-1-phosphate from phosphate and glycogen, comprising a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:159; and optionally, one or more of a polypeptide capable of synthesizing UTP from UDP, comprising a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:123; a polypeptide capable of converting glucose-6-phosphate to glucose-1-phosphate, comprising a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in any one of SEQ ID NO:2, 119, or 143; or at least 55% sequence identity to the amino acid sequence set forth in any one of SEQ ID NO:141, 145, or 147; and/or a polypeptide capable of synthesizing UDP-glucose from UTP and glucose-1-phosphate, comprising a polypeptide having at least 60% sequence identity to the amino acid sequence set forth in any one of SEQ ID NO:121 or 127; at least 55% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:125, 129, 133, 135, 137, or 139; or at least 70% sequence identity to the amino acid sequence set forth in SEQ ID NO:131, and one or more of a polypeptide capable of glycosylating a steviol or the steviol glycoside at its C-13 hydroxyl group thereof; a polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof; and/or a polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; wherein at least one of the polypeptides is a recombinant polypeptide expressed in the recombinant host cell; and producing the one or more steviol glycosides or the steviol glycoside composition thereby, wherein the polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-13 hydroxyl group thereof comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:7; the polypeptide capable of beta 1,3 glycosylation of the C3′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside comprises a polypeptide having at least 50% sequence identity to the amino acid sequence set forth in SEQ ID NO:9; the polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group thereof comprises a polypeptide having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:4; the polypeptide capable of beta 1,2 glycosylation of the C2′ of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside comprises a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:11; a polypeptide having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:13; or a polypeptide having at least 65% sequence identity to the amino acid sequence set forth in SEQ ID NO:16. 
     In one embodiment, the recombinant host cell used in the method of producing one or more steviol glycosides or a steviol glycoside composition in a cell culture is a plant cell, a mammalian cell, an insect cell, a fungal cell, an algal cell, or a bacterial cell, wherein the one or more steviol glycosides is, or the steviol glycoside composition comprises, steviol-13-O-glucoside (13-SMG), steviol-1,2-Bioside, steviol-1,3-Bioside, steviol-19-O-glucoside (19-SMG), 1,2-stevioside, 1,3-stevioside (RebG), rubusoside, rebaudioside A (RebA), rebaudioside B (RebB), rebaudioside C (RebC), rebaudioside D (RebD), rebaudioside E (RebE), rebaudioside F (RebF), rebaudioside M (RebM), rebaudioside Q (RebQ), rebaudioside I (RebI), dulcoside A, and/or an isomer thereof. 
     As used herein, the terms “or” and “and/or” is utilized to describe multiple components in combination or exclusive of one another. For example, “x, y, and/or z” can refer to “x” alone, “y” alone, “z” alone, “x, y, and z,” “(x and y) or z,” “x or (y and z),” or “x or y or z.” In some embodiments, “and/or” is used to refer to the exogenous nucleic acids that a recombinant cell comprises, wherein a recombinant cell comprises one or more exogenous nucleic acids selected from a group. In some embodiments, “and/or” is used to refer to production of steviol glycosides and/or steviol glycoside precursors. In some embodiments, “and/or” is used to refer to production of steviol glycosides, wherein one or more steviol glycosides are produced. In some embodiments, “and/or” is used to refer to production of steviol glycosides, wherein one or more steviol glycosides are produced through one or more of the following steps: culturing a recombinant microorganism, synthesizing one or more steviol glycosides in a recombinant microorganism, and/or isolating one or more steviol glycosides. 
     Functional Homologs 
     Functional homologs of the polypeptides described above are also suitable for use in producing steviol glycosides in a recombinant host. A functional homolog is a polypeptide that has sequence similarity to a reference polypeptide, and that carries out one or more of the biochemical or physiological function(s) of the reference polypeptide. A functional homolog and the reference polypeptide can be a natural occurring polypeptide, and the sequence similarity can be due to convergent or divergent evolutionary events. As such, functional homologs are sometimes designated in the literature as homologs, or orthologs, or paralogs. Variants of a naturally occurring functional homolog, such as polypeptides encoded by mutants of a wild type coding sequence, can themselves be functional homologs. Functional homologs can also be created via site-directed mutagenesis of the coding sequence for a polypeptide, or by combining domains from the coding sequences for different naturally-occurring polypeptides (“domain swapping”). Techniques for modifying genes encoding functional polypeptides described herein are known and include, inter alia, directed evolution techniques, site-directed mutagenesis techniques and random mutagenesis techniques, and can be useful to increase specific activity of a polypeptide, alter substrate specificity, alter expression levels, alter subcellular location, or modify polypeptide-polypeptide interactions in a desired manner. Such modified polypeptides are considered functional homologs. The term “functional homolog” is sometimes applied to the nucleic acid that encodes a functionally homologous polypeptide. 
     Functional homologs can be identified by analysis of nucleotide and polypeptide sequence alignments. For example, performing a query on a database of nucleotide or polypeptide sequences can identify homologs of steviol glycoside biosynthesis polypeptides. Sequence analysis can involve BLAST, Reciprocal BLAST, or PSI-BLAST analysis of non-redundant databases using a UGT amino acid sequence as the reference sequence. Amino acid sequence is, in some instances, deduced from the nucleotide sequence. Those polypeptides in the database that have greater than 40% sequence identity are candidates for further evaluation for suitability as a steviol glycoside biosynthesis polypeptide. Amino acid sequence similarity allows for conservative amino acid substitutions, such as substitution of one hydrophobic residue for another or substitution of one polar residue for another. If desired, manual inspection of such candidates can be carried out in order to narrow the number of candidates to be further evaluated. Manual inspection can be performed by selecting those candidates that appear to have domains present in steviol glycoside biosynthesis polypeptides, e.g., conserved functional domains. In some embodiments, nucleic acids and polypeptides are identified from transcriptome data based on expression levels rather than by using BLAST analysis. 
     Conserved regions can be identified by locating a region within the primary amino acid sequence of a steviol glycoside biosynthesis polypeptide that is a repeated sequence, forms some secondary structure (e.g., helices and beta sheets), establishes positively or negatively charged domains, or represents a protein motif or domain. See, e.g., the Pfam web site describing consensus sequences for a variety of protein motifs and domains on the World Wide Web at sanger.ac.uk/Software/Pfam/ and pfam.janelia.org/. The information included at the Pfam database is described in Sonnhammer et al.,  Nucl. Acids Res.,  26:320-322 (1998); Sonnhammer et al., Proteins, 28:405-420 (1997); and Bateman et al.,  Nucl. Acids Res.,  27:260-262 (1999). Conserved regions also can be determined by aligning sequences of the same or related polypeptides from closely related species. Closely related species preferably are from the same family. In some embodiments, alignment of sequences from two different species is adequate to identify such homologs. 
     Typically, polypeptides that exhibit at least 40% amino acid sequence identity are useful to identify conserved regions. Conserved regions of related polypeptides exhibit at least 45% amino acid sequence identity (e.g., at least 50%, at least 60%, at least 70%, at least 80%, or at least 90% amino acid sequence identity). In some embodiments, a conserved region exhibits at least 92%, 94%, 96%, 98%, or 99% amino acid sequence identity. 
     For example, polypeptides suitable for producing steviol in a recombinant host include functional homologs of UGTs. 
     Methods to modify the substrate specificity of, for example, a UGT, are known to those skilled in the art, and include without limitation site-directed/rational mutagenesis approaches, random directed evolution approaches and combinations in which random mutagenesis/saturation techniques are performed near the active site of the enzyme. For example see Osmani et al., 2009, Phytochemistry 70: 325-347. 
     A candidate sequence typically has a length that is from 80% to 200% of the length of the reference sequence, e.g., 82, 85, 87, 89, 90, 93, 95, 97, 99, 100, 105, 110, 115, 120, 130, 140, 150, 160, 170, 180, 190, or 200% of the length of the reference sequence. A functional homolog polypeptide typically has a length that is from 95% to 105% of the length of the reference sequence, e.g., 90, 93, 95, 97, 99, 100, 105, 110, 115, or 120% of the length of the reference sequence, or any range between. A % identity for any candidate nucleic acid or polypeptide relative to a reference nucleic acid or polypeptide can be determined as follows. A reference sequence (e.g., a nucleic acid sequence or an amino acid sequence described herein) is aligned to one or more candidate sequences using the computer program Clustal Omega (version 1.2.1, default parameters), which allows alignments of nucleic acid or polypeptide sequences to be carried out across their entire length (global alignment). Chenna et al., 2003,  Nucleic Acids Res.  31(13):3497-500. 
     Clustal Omega calculates the best match between a reference and one or more candidate sequences, and aligns them so that identities, similarities and differences can be determined. Gaps of one or more residues can be inserted into a reference sequence, a candidate sequence, or both, to maximize sequence alignments. For fast pairwise alignment of nucleic acid sequences, the following default parameters are used: word size: 2; window size: 4; scoring method: %age; number of top diagonals: 4; and gap penalty: 5. For multiple alignment of nucleic acid sequences, the following parameters are used: gap opening penalty: 10.0; gap extension penalty: 5.0; and weight transitions: yes. For fast pairwise alignment of protein sequences, the following parameters are used: word size: 1; window size: 5; scoring method: % age; number of top diagonals: 5; gap penalty: 3. For multiple alignment of protein sequences, the following parameters are used: weight matrix: blosum; gap opening penalty: 10.0; gap extension penalty: 0.05; hydrophilic gaps: on; hydrophilic residues: Gly, Pro, Ser, Asn, Asp, Gln, Glu, Arg, and Lys; residue-specific gap penalties: on. The Clustal Omega output is a sequence alignment that reflects the relationship between sequences. Clustal Omega can be run, for example, at the Baylor College of Medicine Search Launcher site on the World Wide Web (searchlauncher.bcm.tmc.edu/multi-align/multi-align.html) and at the European Bioinformatics Institute site at http://www.ebi.ac.uk/Tools/msa/clustalo/. 
     To determine a % identity of a candidate nucleic acid or amino acid sequence to a reference sequence, the sequences are aligned using Clustal Omega, the number of identical matches in the alignment is divided by the length of the reference sequence, and the result is multiplied by 100. It is noted that the % identity value can be rounded to the nearest tenth. For example, 78.11, 78.12, 78.13, and 78.14 are rounded down to 78.1, while 78.15, 78.16, 78.17, 78.18, and 78.19 are rounded up to 78.2. 
     It will be appreciated that functional UGT proteins (e.g., a polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-19 carboxyl group) can include additional amino acids that are not involved in the enzymatic activities carried out by the enzymes. In some embodiments, UGT proteins are fusion proteins. The terms “chimera,” “fusion polypeptide,” “fusion protein,” “fusion enzyme,” “fusion construct,” “chimeric protein,” “chimeric polypeptide,” “chimeric construct,” and “chimeric enzyme” can be used interchangeably herein to refer to proteins engineered through the joining of two or more genes that code for different proteins. 
     In some embodiments, a nucleic acid sequence encoding a UGT polypeptide (e.g., a polypeptide capable of glycosylating the steviol or the steviol glycoside at its C-19 carboxyl group) can include a tag sequence that encodes a “tag” designed to facilitate subsequent manipulation (e.g., to facilitate purification or detection), secretion, or localization of the encoded polypeptide. Tag sequences can be inserted in the nucleic acid sequence encoding the polypeptide such that the encoded tag is located at either the carboxyl or amino terminus of the polypeptide. Non-limiting examples of encoded tags include green fluorescent protein (GFP), human influenza hemagglutinin (HA), glutathione S transferase (GST), polyhistidine-tag (HIS tag), and Flag™ tag (Kodak, New Haven, Conn.). Other examples of tags include a chloroplast transit peptide, a mitochondrial transit peptide, an amyloplast peptide, signal peptide, or a secretion tag. 
     In some embodiments, a fusion protein is a protein altered by domain swapping. As used herein, the term “domain swapping” is used to describe the process of replacing a domain of a first protein with a domain of a second protein. In some embodiments, the domain of the first protein and the domain of the second protein are functionally identical or functionally similar. In some embodiments, the structure and/or sequence of the domain of the second protein differs from the structure and/or sequence of the domain of the first protein. In some embodiments, a UGT polypeptide (e.g., a polypeptide capable of glycosylating a steviol or a steviol glycoside at its C-19 carboxyl group) is altered by domain swapping. 
     In some embodiments, a fusion protein is a protein altered by circular permutation, which consists in the covalent attachment of the ends of a protein that would be opened elsewhere afterwards. Thus, the order of the sequence is altered without causing changes in the amino acids of the protein. In some embodiments, a targeted circular permutation can be produced, for example but not limited to, by designing a spacer to join the ends of the original protein. Once the spacer has been defined, there are several possibilities to generate permutations through generally accepted molecular biology techniques, for example but not limited to, by producing concatemers by means of PCR and subsequent amplification of specific permutations inside the concatemer or by amplifying discrete fragments of the protein to exchange to join them in a different order. The step of generating permutations can be followed by creating a circular gene by binding the fragment ends and cutting back at random, thus forming collections of permutations from a unique construct. 
     Steviol and Steviol Glycoside Biosynthesis Nucleic Acids 
     A recombinant gene encoding a polypeptide described herein comprises the coding sequence for that polypeptide, operably linked in sense orientation to one or more regulatory regions suitable for expressing the polypeptide. Because many microorganisms are capable of expressing multiple gene products from a polycistronic mRNA, multiple polypeptides can be expressed under the control of a single regulatory region for those microorganisms, if desired. A coding sequence and a regulatory region are considered to be operably linked when the regulatory region and coding sequence are positioned so that the regulatory region is effective for regulating transcription or translation of the sequence. Typically, the translation initiation site of the translational reading frame of the coding sequence is positioned between one and about fifty nucleotides downstream of the regulatory region for a monocistronic gene. 
     In many cases, the coding sequence for a polypeptide described herein is identified in a species other than the recombinant host, i.e., is a heterologous nucleic acid. Thus, if the recombinant host is a microorganism, the coding sequence can be from other prokaryotic or eukaryotic microorganisms, from plants or from animals. In some case, however, the coding sequence is a sequence that is native to the host and is being reintroduced into that organism. A native sequence can often be distinguished from the naturally occurring sequence by the presence of non-natural sequences linked to the exogenous nucleic acid, e.g., non-native regulatory sequences flanking a native sequence in a recombinant nucleic acid construct. In addition, stably transformed exogenous nucleic acids typically are integrated at positions other than the position where the native sequence is found. “Regulatory region” refers to a nucleic acid having nucleotide sequences that influence transcription or translation initiation and rate, and stability and/or mobility of a transcription or translation product. Regulatory regions include, without limitation, promoter sequences, enhancer sequences, response elements, protein recognition sites, inducible elements, protein binding sequences, 5′ and 3′ untranslated regions (UTRs), transcriptional start sites, termination sequences, polyadenylation sequences, introns, and combinations thereof. A regulatory region typically comprises at least a core (basal) promoter. A regulatory region also may include at least one control element, such as an enhancer sequence, an upstream element or an upstream activation region (UAR). A regulatory region is operably linked to a coding sequence by positioning the regulatory region and the coding sequence so that the regulatory region is effective for regulating transcription or translation of the sequence. For example, to operably link a coding sequence and a promoter sequence, the translation initiation site of the translational reading frame of the coding sequence is typically positioned between one and about fifty nucleotides downstream of the promoter. A regulatory region can, however, be positioned as much as about 5,000 nucleotides upstream of the translation initiation site, or about 2,000 nucleotides upstream of the transcription start site. 
     The choice of regulatory regions to be included depends upon several factors, including, but not limited to, efficiency, selectability, inducibility, desired expression level, and preferential expression during certain culture stages. It is a routine matter for one of skill in the art to modulate the expression of a coding sequence by appropriately selecting and positioning regulatory regions relative to the coding sequence. It will be understood that more than one regulatory region may be present, e.g., introns, enhancers, upstream activation regions, transcription terminators, and inducible elements. 
     One or more genes can be combined in a recombinant nucleic acid construct in “modules” useful for a discrete aspect of steviol and/or steviol glycoside production. Combining a plurality of genes in a module, particularly a polycistronic module, facilitates the use of the module in a variety of species. For example, a steviol biosynthesis gene cluster, or a UGT gene cluster, can be combined in a polycistronic module such that, after insertion of a suitable regulatory region, the module can be introduced into a wide variety of species. As another example, a UGT gene cluster can be combined such that each UGT coding sequence is operably linked to a separate regulatory region, to form a UGT module. Such a module can be used in those species for which monocistronic expression is necessary or desirable. In addition to genes useful for a steviol or steviol glycoside production, a recombinant construct typically also contains an origin of replication, and one or more selectable markers for maintenance of the construct in appropriate species. 
     It will be appreciated that because of the degeneracy of the genetic code, a number of nucleic acids can encode a particular polypeptide; i.e., for many amino acids, there is more than one nucleotide triplet that serves as the codon for the amino acid. Thus, codons in the coding sequence for a given polypeptide can be modified such that optimal expression in a particular host is obtained, using appropriate codon bias tables for that host (e.g., microorganism). As isolated nucleic acids, these modified sequences can exist as purified molecules and can be incorporated into a vector or a virus for use in constructing modules for recombinant nucleic acid constructs. 
     In some cases, it is desirable to inhibit one or more functions of an endogenous polypeptide in order to divert metabolic intermediates towards a steviol or steviol glycoside biosynthesis. For example, it may be desirable to downregulate synthesis of sterols in a yeast strain in order to further increase the steviol or the steviol glycoside production, e.g., by downregulating squalene epoxidase. As another example, it may be desirable to inhibit degradative functions of certain endogenous gene products, e.g., glycohydrolases that remove glucose moieties from secondary metabolites or phosphatases as discussed herein. In such cases, a nucleic acid that overexpresses the polypeptide or gene product may be included in a recombinant construct that is transformed into the strain. Alternatively, mutagenesis can be used to generate mutants in genes for which it is desired to increase or enhance function. 
     Host Microorganisms 
     Recombinant hosts can be used to express polypeptides for producing steviol glycosides, including, but not limited to, a plant cell, comprising a plant cell that is grown in a plant, a mammalian cell, an insect cell, a fungal cell, an algal cell, or a bacterial cell. 
     A number of prokaryotes and eukaryotes are also suitable for use in constructing the recombinant microorganisms described herein, e.g., gram-negative bacteria, yeast, and fungi. A species and strain selected for use as a steviol glycoside production strain is first analyzed to determine which production genes are endogenous to the strain and which genes are not present. Genes for which an endogenous counterpart is not present in the strain are advantageously assembled in one or more recombinant constructs, which are then transformed into the strain in order to supply the missing function(s). 
     Typically, the recombinant microorganism is grown in a fermenter at a temperature(s) for a period of time, wherein the temperature and period of time facilitate the production of a steviol glycoside. The constructed and genetically engineered microorganisms provided by the invention can be cultivated using conventional fermentation processes, including, inter alia, chemostat, batch, fed-batch cultivations, semi-continuous fermentations such as draw and fill, continuous perfusion fermentation, and continuous perfusion cell culture. Depending on the particular microorganism used in the method, other recombinant genes such as isopentenyl biosynthesis genes and terpene synthase and cyclase genes may also be present and expressed. Levels of substrates and intermediates, e.g., isopentenyl diphosphate, dimethylallyl diphosphate, GGPP, ent-kaurene and ent-kaurenoic acid, can be determined by extracting samples from culture media for analysis according to published methods. 
     In some aspects, the recombinant microorganism is grown in a deep well plate. It will be understood that while data on production of steviol glycosides by the recombinant microorganism grown in deep well cultures, in some aspects, may be more easily collected than that in fermentation cultures, the small culture volume of the deep well (e.g., 1 ml or 0.5 ml) can effect differences in the environment of the microorganism and, therefore its efficiency and effectiveness in producing steviol glycosides. For example, nutrient availability, cellular waste product buildup, pH, temperature, agitation, and aeration may differ significantly between fermentation and deep well cultures. Accordingly, uptake of nutrients or other enzyme substrates may vary, affecting the cellular metabolism (e.g., changing the amount and/or profile of products accumulated by a recombinant microorganism). See, e.g., Duetz,  Trends Microbiol  15(10):469-75 (2007). 
     Carbon sources of use in the instant method include any molecule that can be metabolized by the recombinant host cell to facilitate growth and/or production of the steviol glycosides. Examples of suitable carbon sources include, but are not limited to, sucrose (e.g., as found in molasses), fructose, xylose, ethanol, glycerol, glucose, cellulose, starch, cellobiose or other glucose-comprising polymer. In embodiments employing yeast as a host, for example, carbons sources such as sucrose, fructose, xylose, ethanol, glycerol, and glucose are suitable. The carbon source can be provided to the host organism throughout the cultivation period or alternatively, the organism can be grown for a period of time in the presence of another energy source, e.g., protein, and then provided with a source of carbon only during the fed-batch phase. 
     It will be appreciated that the various genes and modules discussed herein can be present in two or more recombinant hosts rather than a single host. When a plurality of recombinant hosts is used, they can be grown in a mixed culture to accumulate steviol and/or steviol glycosides. 
     Alternatively, the two or more hosts each can be grown in a separate culture medium and the product of the first culture medium, e.g., steviol, can be introduced into second culture medium to be converted into a subsequent intermediate, or into an end product such as, for example, RebA. The product produced by the second, or final host is then recovered. It will also be appreciated that in some embodiments, a recombinant host is grown using nutrient sources other than a culture medium and utilizing a system other than a fermenter. 
     Exemplary prokaryotic and eukaryotic species are described in more detail below. However, it will be appreciated that other species can be suitable. However, it will be appreciated that other species can be suitable to express polypeptides for the producing steviol glycosides. 
     For example, suitable species can be in a genus such as  Agaricus, Aspergillus, Bacillus, Candida, Corynebacterium, Eremothecium, Escherichia, Fusarium/Gibberella, Kluyveromyces, Laetiporus, Lentinus, Phaffia, Phanerochaete, Pichia  (formally known as  Hansuela ),  Scheffersomyces, Physcomitrella, Rhodoturula, Saccharomyces, Schizosaccharomyces, Sphaceloma, Xanthophyllomyces, Humicola, lssatchenkia, Brettanomyces, Yamadazyma, Lachancea, Zygosaccharomyces, Komagataella, Kazachstania, Xanthophyllomyces, Geotrichum, Blakeslea, Dunaliella, Haematococcus, Chlorella, Undaria, Sargassum, Laminaria, Scenedesmus, Pachysolen, Trichosporon, Acremonium, Aureobasidium, Cryptococcus, Corynascus, Chrysosporium, Filibasidium, Fusarium, Magnaporthe, Monascus, Mucor, Myceliophthora, Mortierella, Neocallimastix, Neurospora, Paecilomyces, Penicillium, Piromyces, Pachysolen, Phanerochaete, Podospora, Pycnoporus, Rhizopus, Schizophyllum, Sordaria, Talaromyces, Rasmsonia, Thermoascus, Thielavia, Tolypocladium, Kloeckera, Pachysolen, Schwanniomyces, Trametes, Trichoderma, Acinetobacter, Nocardia, Xanthobacter, Streptomyces, Erwinia, Klebsiella, Serratia, Pseudomonas, Salmonella, Choroflexus, Chloronema, Chlorobium, Pelodictyon, Chromatium, Rhode - spirillum, Rhodobacter, Rhodomicrobium,  or  Yarrowia.    
     Exemplary species from such genera include  Lentinus tigrinus, Laetiporus sulphureus, Phanerochaete chrysosporium, Pichia pastoris, Pichia kudriavzevii, Cyberlindnera jadinii, Physcomitrella patens, Rhodoturula glutinis, Rhodoturula mucilaginosa, Phaffia rhodozyma, Xanthophyllomyces dendrorhous, lssatchenkia orientalis, Saccharomyces cerevisiae, Saccharomyces bayanus, Saccharomyces pastorianus, Saccharomyces carlsbergensis, Hansuela polymorpha, Brettanomyces anomalus, Yamadazyma philogaea, Fusarium fujikuroil Gibberella fujikuroi, Candida utilis, Candida glabrata, Candida krusei, Candida revkaufi, Candida pulcherrima, Candida tropicalis, Aspergillus niger, Aspergillus oryzae, Aspergillus fumigatus, Penicillium chrysogenum, Penicillium citrinum, Acremonium chrysogenum, Trichoderma reesei, Rasamsonia emersonfi  (formerly known as  Talaromyces emersonfi ),  Aspergillus sojae, Chrysosporium lucknowense, Myceliophtora thermophyla, Candida albicans, Bacillus subtilis, Bacillus amyloliquefaciens, Bacillius licheniformis, Bacillus puntis, Bacillius megaterium, Bacillius halofurans, Baciilius punilus, Serratia marcessans, Pseudomonas aeruginosa, Salmonella typhimurium, Blakeslea trispora, Dunaliella salina, Haematococcus pluvialis, Chlorella sp., Undaria pinnatifida, Sargassum, Laminaria japonica, Scenedesmus almeriensis, Salmonella typhi, Choroflexus aurantiacus, Chloronema gigateum, Chlorobium limicola, Pelodictyon luteolum, Chromatium okenii, Rhode - spirillum rubrum, Rhodobacter spaeroides, Rhodobacter capsulatus, Rhodomicrobium vanellii, Pachysolen tannophilus, Trichosporon beigelii,  and  Yarrowia lipolytica.    
     In some embodiments, a microorganism can be a prokaryote such as  Escherichia  bacteria cells, for example,  Escherichia coli  cells;  Lactobacillus  bacteria cells;  Lactococcus  bacteria cells;  Cornebacterium  bacteria cells;  Acetobacter  bacteria cells;  Acinetobacter  bacteria cells; or  Pseudomonas  bacterial cells. 
     In some embodiments, a microorganism can be an algal cell such as  Blakeslea trispora, Dunaliella salina, Haematococcus pluvialis, Chlorella  sp.,  Undaria pinnatifida, Sargassum, Laminaria japonica, Scenedesmus almeriensis  species. 
     In some embodiments, a microorganism can be a fungi from the genera including but not limited to  Acremonium, Arxula, Agaricus, Aspergillus, Agaricus, Aureobasidium, Brettanomyces, Candida, Cryptococcus, Corynascus, Chrysosporium, Debaromyces, Filibasidium, Fusarium, Gibberella, Humicola, Magnaporthe, Monascus, Mucor, Myceliophthora, Mortierella, Neocallimastix, Neurospora, Paecilomyces, Penicillium, Piromyces, Phanerochaete Podospora, Pycnoporus, Rhizopus, Schizophyllum, Schizosaccharomyces, Sordaria, Scheffersomyces, Talaromyces, Rhodotorula, Rhodosporidium, Rasmsonia, Zygosaccharomyces, Thermoascus, Thielavia, Trichosporon, Tolypocladium, Trametes,  and  Trichoderma.  Fungal species include, but are not limited to,  Aspergillus niger, Aspergillus oryzae, Aspergillus fumigatus, Penicillium chrysogenum, Penicillium citrinum, Acremonium chrysogenum, Trichoderma reesei, Rasamsonia emersonii  (formerly known as  Talaromyces emersonii ),  Aspergillus sojae, Chrysosporium lucknowense, Myceliophtora thermophyla.    
     In some embodiments, a microorganism can be an Ascomycete such as  Gibberella fujikuroi, Kluyveromyces lactis, Schizosaccharomyces pombe, Geotrichum Aspergillus niger, Yarrowia lipolytica, Ashbya gossypii, Yamadazyma philogaea, Lachancea kluyveri, Kodamaea ohmeri,  or  S. cerevisiae.    
       Agaricus, Gibberella,  and  Phanerochaete  spp. 
       Agaricus, Gibberella,  and  Phanerochaete  spp. can be useful because they are known to produce large amounts of isoprenoids in culture. Thus, the terpene precursors for producing large amounts of steviol glycosides are already produced by endogenous genes. Thus, modules comprising recombinant genes for steviol glycoside biosynthesis polypeptides can be introduced into species from such genera without the necessity of introducing mevalonate or MEP pathway genes. 
       Arxula Adeninivorans  ( Blastobotrys Adeninivorans ) 
       Arxula adeninivorans  is dimorphic yeast (it grows as budding yeast like the baker&#39;s yeast up to a temperature of 42° C., above this threshold it grows in a filamentous form) with unusual biochemical characteristics. It can grow on a wide range of substrates and can assimilate nitrate. It has successfully been applied to the generation of strains that can produce natural plastics or the development of a biosensor for estrogens in environmental samples. 
       Rhodotorula  sp. 
       Rhodotorula  is unicellular, pigmented yeast. The oleaginous red yeast,  Rhodotorula glutinis,  has been shown to produce lipids and carotenoids from crude glycerol (Saenge et al., 2011,  Process Biochemistry  46(1):210-8).  Rhodotorula toruloides  strains have been shown to be an efficient fed-batch fermentation system for improved biomass and lipid productivity (Li et al., 2007,  Enzyme and Microbial Technology  41:312-7). 
       Schizosaccharomyces  spp. 
       Schizosaccharomyces  is a genus of fission yeasts. Similar to  S. cerevisiae, Schizosaccharomyces  is a model organism in the study of eukaryotic cell biology. It provides an evolutionary distant comparison to  S. cerevisiae.  Species include but are not limited to  S. cryophilius  and  S. pombe.  (See Hoffman et al., 2015, Genetics. 201(2):403-23). 
       Humicola  spp. 
       Humicola  is a genus of filamentous fungi. Species include but are not limited to  H. alopallonella  and  H. siamensis.    
       Brettanomyces  spp. 
       Brettanomyces  is a non-spore forming genus of yeast. It is from the Saccharomycetaceae family and commonly used in the brewing and wine industries.  Brettanomyces  produces several sensory compounds that contribute to the complexity of wine, specifically red wine.  Brettanomyces  species include but are not limited to  B. bruxellensis  and  B. claussenii.  See, e.g., Fugelsang et al., 1997,  Wine Microbiology.    
       Trichosporon  spp. 
       Trichosporon  is a genus of the fungi family.  Trichosporon  species are yeast commonly isolated from the soil, but can also be found in the skin microbiota of humans and animals. Species include, for example but are not limited to,  T. aquatile, T. beigelii,  and  T. dermatis.    
       Debaromyces  spp. 
       Debaromyces  is a genus of the ascomycetous yeast family, in which species are characterized as a salt-tolerant marine species. Species include but are not limited to  D. hansenii  and  D. hansenius.    
       Physcomitrella  spp. 
       Physcomitrella mosses,  when grown in suspension culture, have characteristics similar to yeast or other fungal cultures. This genera can be used for producing plant secondary metabolites, which can be difficult to produce in other types of cells. 
       Saccharomyces  spp. 
       Saccharomyces  is a widely used chassis organism in synthetic biology, and can be used as the recombinant microorganism platform. For example, there are libraries of mutants, plasmids, detailed computer models of metabolism and other information available for  S. cerevisiae,  allowing for rational design of various modules to enhance product yield. Methods are known for making recombinant microorganisms. Examples of  Saccharomyces  species include  S. castellii,  also known as  Naumovozyma castelli.    
       Zygosaccharomyces  spp. 
       Zygosaccharomyces  is a genus of yeast. Originally classified under the  Saccharomyces  genus it has since been reclassified. It is widely known in the food industry because several species are extremely resistant to commercially used food preservation techniques. Species include but are not limited to  Z. bisporus  and  Z. cidri.  (See Barnett et al, Yeasts: Characteristics and Identification, 1983). 
       Geotrichum  spp. 
       Geotrichum  is a fungi commonly found in soil, water and sewage worldwide. It&#39;s often identified in plants, cereal and dairy products. Species include, for example but are not limited to,  G. candidum  and  G. klebahnii  (see Carmichael et al.,  Mycologica,  1957, 49(6):820-830.) 
       Kazachstania  sp 
       Kazachstania  is a yeast genus in the family Sacchromycetaceae. 
       Torulaspora  spp. 
       Torulaspora  is a genus of yeasts and species include but are not limited to  T. franciscae  and  T. globosa.    
       Aspergillus  spp. 
       Aspergillus  species such as  A. oryzae, A. niger  and  A. sojae  are widely used microorganisms in food production and can also be used as the recombinant microorganism platform. Nucleotide sequences are available for genomes of  A. nidulans, A. fumigatus, A. oryzae, A. clavatus, A. flavus, A. niger,  and  A. terreus,  allowing rational design and modification of endogenous pathways to enhance flux and increase product yield. Metabolic models have been developed for  Aspergillus,  as well as transcriptomic studies and proteomics studies.  A. niger  is cultured for the industrial production of a number of food ingredients such as citric acid and gluconic acid, and thus species such as  A. niger  are generally suitable for producing steviol glycosides. 
     
       Yarrowia Lipolytica  
     
       Yarrowia lipolytica  is dimorphic yeast (see  Arxula adeninivorans ) and belongs to the family Hemiascomycetes. The entire genome of  Yarrowia lipolytica  is known.  Yarrowia  species is aerobic and considered to be non-pathogenic.  Yarrowia  is efficient in using hydrophobic substrates (e.g., alkanes, fatty acids, and oils) and can grow on sugars. It has a high potential for industrial applications and is an oleaginous microorganism.  Yarrowia lipolyptica  can accumulate lipid content to approximately 40% of its dry cell weight and is a model organism for lipid accumulation and remobilization. See e.g., Nicaud, 2012,  Yeast  29(10):409-18; Beopoulos et al., 2009,  Biochimie  91(6):692-6; Bankar et al., 2009,  Appl Microbiol Biotechnol.  84(5):847-65. 
     
       Rhodosporidium Toruloides  
     
       Rhodosporidium toruloides  is oleaginous yeast and useful for engineering lipid-production pathways (See e.g. Zhu et al., 2013,  Nature Commun.  3:1112; Ageitos et al., 2011,  Applied Microbiology and Biotechnology  90(4):1219-27). 
     
       Candida Boidinii  
     
       Candida boidinii  is methylotrophic yeast (it can grow on methanol). Like other methylotrophic species such as  Hansenula polymorpha  and  Pichia pastoris,  it provides an excellent platform for producing heterologous proteins. Yields in a multigram range of a secreted foreign protein have been reported. A computational method, IPRO, recently predicted mutations that experimentally switched the cofactor specificity of  Candida boidinii  xylose reductase from NADPH to NADH. See, e.g., Mattanovich et al., 2012,  Methods Mol Biol.  824:329-58; Khoury et al., 2009,  Protein Sci.  18(10):2125-38. 
       Hansenula Polymorpha  ( Pichia Angusta ) 
       Hansenula polymorpha  is methylotrophic yeast (see  Candida boidinii ). It can furthermore grow on a wide range of other substrates; it is thermo-tolerant and can assimilate nitrate (see also,  Kluyveromyces lactis ). It has been applied to producing hepatitis B vaccines, insulin and interferon alpha-2a for the treatment of hepatitis C, furthermore to a range of technical enzymes. See, e.g., Xu et al., 2014,  Virol Sin.  29(6):403-9. 
       Candida Krusei  ( Issatchenkia Orientalis ) 
       Candida krusei ,  scientific name  Issatchenkia orientalis,  is widely used in chocolate production.  C. krusei  is used to remove the bitter taste of and break down cacao beans. In addition to this species involvement in chocolate production,  C. krusei  is commonly found in the immunocompromised as a fungal nosocomial pathogen (see Mastromarino et al.,  New Microbiolgica,  36:229-238; 2013) 
     
       Kluyveromyces Lactis  
     
       Kluyveromyces lactis  is yeast regularly applied to the production of kefir. It can grow on several sugars, most importantly on lactose which is present in milk and whey. It has successfully been applied among others for producing chymosin (an enzyme that is usually present in the stomach of calves) for producing cheese. Production takes place in fermenters on a 40,000 L scale. See, e.g., van Ooyen et al., 2006,  FEMS Yeast Res.  6(3):381-92. 
     
       Pichia Pastoris  
     
       Pichia pastoris  is methylotrophic yeast (see  Candida boidinii  and  Hansenula polymorpha ). It is also commonly referred to as  Komagataella pastoris.  It provides an efficient platform for producing foreign proteins. Platform elements are available as a kit and it is worldwide used in academia for producing proteins. Strains have been engineered that can produce complex human N-glycan (yeast glycans are similar but not identical to those found in humans). See, e.g., Piirainen et al., 2014,  N Biotechnol.  31(6):532-7. 
     
       Scheffersomyces Stipitis  
     
       Scheffersomyces stipitis  also known as  Pichia stipitis  is a homothallic yeast found in haploid form. Commonly used instead of  S. cerevisiae  due to its enhanced respiratory capacity that results from and alternative respiratory system (see Papini et al.,  Microbial Cell Factories,  11:136 (2012)). 
     In some embodiments, a microorganism can be an insect cell such as  Drosophilia,  specifically,  Drosophilia melanogaster.    
     In some embodiments, a microorganism can be an algal cell such as, for example but not limited to,  Blakeslea trispora, Dunaliella salina, Haematococcus pluvialis, Chlorella  sp., 
     In some embodiments, a microorganism can be a cyanobacterial cell such as, for example but not limited to,  Blakeslea trispora, Dunaliella salina, Haematococcus pluvialis, Chlorella  sp.,  Undaria pinnatifida, Sargassum, Laminaria japonica,  and  Scenedesmus almeriensis.    
     In some embodiments, a microorganism can be a bacterial cell. Examples of bacteria include, but are not limited to, the genera  Bacillus  (e.g.,  B. subtilis, B. amyloliquefaciens, B. licheniformis, B. puntis, B. megaterium, B. halodurans, B. pumilus ),  Acinetobacter, Nocardia, Xanthobacter, Escherichia  (e.g.,  E. coli ),  Streptomyces, Erwinia, Klebsiella, Serratia  (e.g.,  S. marcessans ),  Pseudomonas  (e.g.,  P. aeruginosa ),  Salmonella  (e.g.,  S. typhimurium,  and  S. typhi ). Bacterial cells may also include, but are not limited to, photosynthetic bacteria (e.g., green non-sulfur bacteria (e.g.,  Choroflexus  bacteria (e.g.,  C. aurantiacus ),  Chloronema  (e.g.,  C. gigateum ), green sulfur bacteria (e.g.,  Chlorobium  bacteria (e.g.,  C. limicola ),  Pelodictyon  (e.g.,  P. luteolum ), purple sulfur bacteria (e.g.,  Chromatium  (e.g.,  C. okenii )), and purple non-sulfur bacteria (e.g.,  Rhode - spirillum  (e.g.,  R. rubrum ),  Rhodobacter  (e.g.,  R. sphaeroides, R. capsulatus ), and  Rhodomicrobium  bacteria (e.g.,  R. vanellii )). 
     
       E. Coli  
     
       E. coli,  another widely used platform organism in synthetic biology, can also be used as the recombinant microorganism platform. Similar to  Saccharomyces,  there are libraries of mutants, plasmids, detailed computer models of metabolism and other information available for  E. coli,  allowing for rational design of various modules to enhance product yield. Methods similar to those described above for  Saccharomyces  can be used to make recombinant  E. coli  microorganisms. 
     It can be appreciated that the recombinant host cell disclosed herein can comprise a plant cell, comprising a plant cell that is grown in a plant, a mammalian cell, an insect cell, a fungal cell from  Aspergillus  genus; a yeast cell from  Saccharomyces  (e.g.,  S. cerevisiae, S. bayanus, S. pastorianus,  and  S. carlsbergensis ),  Schizosaccharomyces  (e.g.,  S. pombe ),  Yarrowia  (e.g.,  Y. lipolytica ),  Candida  (e.g.,  C. glabrata, C. albicans, C. krusei, C. revkaufi, C. pulcherrima, Candida tropicalis, C. utilis,  and  C. boidinii ),  Ashbya  (e.g.,  A. gossypii ),  Cyberlindnera  (e.g.,  C. jadinii ),  Pichia  (e.g.,  P. pastoris  and  P. kudriavzevii ),  Kluyveromyces  (e.g.,  K. lactis ),  Hansenual  (e.g.,  H. polymorpha ),  Arxula  (e.g.,  A. adeninivorans ),  Xanthophyllomyces  (e.g.,  X. dendrorhous ),  Issatchenkia  (e.g.,  I. orientali ),  Torulaspora  (e.g.,  T. franciscae  and  T. globosa ),  Geotrichum  (e.g.,  G. candidum  and  G. klebahni ),  Zygosaccharomyces  (e.g.,  Z. bisporus  and  Z. cidri ),  Yamadazyma  (e.g.,  Y. philogaea ),  Lanchancea  (e.g.,  L. kluyven ),  Kodamaea  (e.g.,  K. ohmen ),  Brettanomyces  (e.g.,  B. anomalus ),  Trichosporon  (e.g.,  T. aquatile, T. beigelii,  and  T. dermatis ),  Debaromyces  (e.g.,  D. hansenuis  and  D. hansenii ),  Scheffersomyces  (e.g.,  S. stipis ),  Rhodosporidium  (e.g.,  R. toruloides ),  Pachysolen  (e.g.,  P. tannophilus ), and  Physcomitrella, Rhodotorula, Kazachstania, Gibberella, Agaricus,  and  Phanerochaete  genera; an insect cell including, but not limited to,  Drosophilia melanogaster,  an algal cell including, but not limited to,  Blakeslea trispora, Dunaliella salina, Haematococcus pluvialis, Chlorella  sp.,  Undaria pinnatifida, Sargassum, Laminaria japonica,  and  Scenedesmus almeriensis  species; or a bacterial cell from  Bacillus  genus (e.g.,  B. subtilis, B. amyloliquefaciens, B. licheniformis, B. puntis, B. megaterium, B. halodurans,  and  B. pumilus )  Acinetobacter, Nocardia, Xanthobacter genera, Escherichia  (e.g.,  E. coli ),  Streptomyces, Erwinia, Klebsiella, Serratia  (e.g.,  S. marcessans ),  Pseudomonas  (e.g.,  P. aeruginosa ),  Salmonella  (e.g.,  S. typhimurium  and  S. typhi ), and further including,  Choroflexus  bacteria (e.g.,  C. aurantiacus ),  Chloronema  (e.g.,  C. gigateum ), green sulfur bacteria (e.g.,  Chlorobium  bacteria (e.g.,  C. limicola ),  Pelodictyon  (e.g.,  P. luteolum )), purple sulfur bacteria (e.g.,  Chromatium  (e.g.,  C. okenii )), and purple non-sulfur bacteria (e.g.,  Rhode - spirillum  (e.g.,  R. rubrum ),  Rhodobacter  (e.g.,  R. sphaeroides  and  R. capsulatus ), and  Rhodomicrobium  bacteria (e.g.,  R. vanellii ). 
     Steviol Glycoside Compositions 
     Steviol glycosides do not necessarily have equivalent performance in different food systems. It is therefore desirable to have the ability to direct the synthesis to steviol glycoside compositions of choice. Recombinant hosts described herein can produce compositions that are selectively enriched for specific steviol glycosides (e.g., RebD or RebM) and have a consistent taste profile. As used herein, the term “enriched” is used to describe a steviol glycoside composition with an increased proportion of a particular steviol glycoside, compared to a steviol glycoside composition (extract) from a  Stevia  plant. Thus, the recombinant hosts described herein can facilitate the production of compositions that are tailored to meet the sweetening profile desired for a given food product and that have a proportion of each steviol glycoside that is consistent from batch to batch. In some embodiments, hosts described herein do not produce or produce a reduced amount of undesired plant by-products found in  Stevia  extracts. Thus, steviol glycoside compositions produced by the recombinant hosts described herein are distinguishable from compositions derived from  Stevia  plants. 
     The amount of an individual steviol glycoside (e.g., RebA, RebB, RebD, or RebM) accumulated can be from about 1 to about 7,000 mg/L, e.g., about 1 to about 10 mg/L, about 3 to about 10 mg/L, about 5 to about 20 mg/L, about 10 to about 50 mg/L, about 10 to about 100 mg/L, about 25 to about 500 mg/L, about 100 to about 1,500 mg/L, or about 200 to about 1,000 mg/L, at least 1,000 mg/L, at least 1,200 mg/L, at least at least 1,400 mg/L, at least 1,600 mg/L, at least 1,800 mg/L, at least 2,800 mg/L, or at least 7,000 mg/L. In some aspects, the amount of an individual steviol glycoside can exceed 7,000 mg/L. The amount of a combination of steviol glycosides (e.g., RebA, RebB, RebD, or RebM) accumulated can be from about 1 mg/L to about 7,000 mg/L, e.g., about 200 to about 1,500, at least 2,000 mg/L, at least 3,000 mg/L, at least 4,000 mg/L, at least 5,000 mg/L, at least 6,000 mg/L, or at least 7,000 mg/L. In some aspects, the amount of a combination of steviol glycosides can exceed 7,000 mg/L. In general, longer culture times will lead to greater amounts of product. Thus, the recombinant microorganism can be cultured for from 1 day to 7 days, from 1 day to 5 days, from 3 days to 5 days, about 3 days, about 4 days, or about 5 days. 
     The amount of compounds accumulated by the recombinant host may be reported as a “flux.” For example, the “total flux” may be calculated as a sum (in g/L RebD equivalents) of measured RebA, RebB, RebD, RebE, RebM, 13-SMG, rubusoside, steviol-1,2-bioside, di-glycosylated steviol, tri-glycosylated steviol, tetra-glycosylated steviol, penta-glycosylated steviol, hexa-glycosylated steviol, hepta-glycosylated steviol, copalol, ent-kaurenoic acid, glycosylated ent-kaurenoic acid, glycosylated ent-kaurenol, ent-kaurenal, geranylgeraniol, ent-kaurenal, and ent-kaurene levels. Individual compounds, such as individual steviol glycosides, or groups of compounds, such as the group of steviol glycosides, may be reported as a fraction of total flux. For example, “steviol glycoside/flux” may calculated as ((“total flux”−(geranylgeraniol+copalol+ent-kaurene+glycosylated ent-kaurenol+ent-kaurenol+ent-kaurenal+ent-kaurenoic acid+glycosylated ent-kaurenoic acid)/“total flux”). 
     It will be appreciated that the various genes and modules discussed herein can be present in two or more recombinant microorganisms rather than a single microorganism. When a plurality of recombinant microorganisms is used, they can be grown in a mixed culture to produce steviol and/or steviol glycosides. For example, a first microorganism can comprise one or more biosynthesis genes for producing a steviol glycoside precursor, while a second microorganism comprises steviol glycoside biosynthesis genes. The product produced by the second, or final microorganism is then recovered. It will also be appreciated that in some embodiments, a recombinant microorganism is grown using nutrient sources other than a culture medium and utilizing a system other than a fermenter. 
     Alternatively, the two or more microorganisms each can be grown in a separate culture medium and the product of the first culture medium, e.g., steviol, can be introduced into second culture medium to be converted into a subsequent intermediate, or into an end product such as RebA. The product produced by the second, or final microorganism is then recovered. It will also be appreciated that in some embodiments, a recombinant microorganism is grown using nutrient sources other than a culture medium and utilizing a system other than a fermenter. 
     Steviol glycosides and compositions obtained by the methods disclosed herein can be used to make food products, dietary supplements and sweetener compositions. See, e.g., WO 2011/153378, WO 2013/022989, WO 2014/122227, and WO 2014/122328. 
     For example, substantially pure steviol or steviol glycoside such as RebM or RebD can be included in food products such as ice cream, carbonated drinks, fruit juices, yogurts, baked goods, chewing gums, hard and soft candies, and sauces. Substantially pure steviol or the steviol glycoside can also be included in non-food products such as pharmaceutical products, medicinal products, dietary supplements and nutritional supplements. Substantially pure steviol or the steviol glycosides may also be included in animal feed products for both the agriculture industry and the companion animal industry. Alternatively, a mixture of steviol and/or steviol glycosides can be made by culturing recombinant microorganisms separately, each producing a specific steviol glycoside, recovering the steviol or the steviol glycoside in substantially pure form from each microorganism and then combining the compounds to obtain a mixture comprising each compound in the desired proportion. The recombinant microorganisms described herein permit more precise and consistent mixtures to be obtained compared to current  Stevia  products. 
     In another alternative, a substantially pure steviol or steviol glycoside can be incorporated into a food product along with other sweeteners, e.g., saccharin, dextrose, sucrose, fructose, erythritol, aspartame, sucralose, monatin, or acesulfame potassium. The weight ratio of the steviol or the steviol glycoside relative to other sweeteners can be varied as desired to achieve a satisfactory taste in the final food product. See, e.g., U.S. 2007/0128311. In some embodiments, the steviol or the steviol glycoside may be provided with a flavor (e.g., citrus) as a flavor modulator. 
     Compositions produced by a recombinant microorganism described herein can be incorporated into food products. For example, a steviol glycoside composition produced by a recombinant microorganism can be incorporated into a food product in an amount ranging from about 20 mg steviol glycoside/kg food product to about 1800 mg steviol glycoside/kg food product on a dry weight basis, depending on the type of steviol glycoside and food product. For example, a steviol glycoside composition produced by a recombinant microorganism can be incorporated into a dessert, cold confectionary (e.g., ice cream), dairy product (e.g., yogurt), or beverage (e.g., a carbonated beverage) such that the food product has a maximum of 500 mg steviol glycoside/kg food on a dry weight basis. A steviol glycoside composition produced by a recombinant microorganism can be incorporated into a baked good (e.g., a biscuit) such that the food product has a maximum of 300 mg steviol glycoside/kg food on a dry weight basis. A steviol glycoside composition produced by a recombinant microorganism can be incorporated into a sauce (e.g., chocolate syrup) or vegetable product (e.g., pickles) such that the food product has a maximum of 1000 mg steviol glycoside/kg food on a dry weight basis. A steviol glycoside composition produced by a recombinant microorganism can be incorporated into bread such that the food product has a maximum of 160 mg steviol glycoside/kg food on a dry weight basis. A steviol glycoside composition produced by a recombinant microorganism, plant, or plant cell can be incorporated into a hard or soft candy such that the food product has a maximum of 1600 mg steviol glycoside/kg food on a dry weight basis. A steviol glycoside composition produced by a recombinant microorganism, plant, or plant cell can be incorporated into a processed fruit product (e.g., fruit juices, fruit filling, jams, and jellies) such that the food product has a maximum of 1000 mg steviol glycoside/kg food on a dry weight basis. In some embodiments, a steviol glycoside composition produced herein is a component of a pharmaceutical composition. See, e.g., Steviol Glycosides Chemical and Technical Assessment 69th JECFA, 2007, prepared by Harriet Wallin, Food Agric. Org.; EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), “Scientific Opinion on the safety of steviol glycosides for the proposed uses as a food additive,” 2010, EFSA Journal 8(4):1537; U.S. Food and Drug Administration GRAS Notice 323; U.S Food and Drug Administration GRAS Notice 329; WO 2011/037959; WO 2010/146463; WO 2011/046423; and WO 2011/056834. 
     For example, such a steviol glycoside composition can have from 90-99 weight % RebA and an undetectable amount of  Stevia  plant-derived contaminants, and be incorporated into a food product at from 25-1600 mg/kg, e.g., 100-500 mg/kg, 25-100 mg/kg, 250-1000 mg/kg, 50-500 mg/kg or 500-1000 mg/kg on a dry weight basis. 
     Such a steviol glycoside composition can be a RebB-enriched composition having greater than 3 weight % RebB and be incorporated into the food product such that the amount of RebB in the product is from 25-1600 mg/kg, e.g., 100-500 mg/kg, 25-100 mg/kg, 250-1000 mg/kg, 50-500 mg/kg or 500-1000 mg/kg on a dry weight basis. Typically, the RebB-enriched composition has an undetectable amount of  Stevia  plant-derived contaminants. 
     Such a steviol glycoside composition can be a RebD-enriched composition having greater than 3 weight % RebD and be incorporated into the food product such that the amount of RebD in the product is from 25-1600 mg/kg, e.g., 100-500 mg/kg, 25-100 mg/kg, 250-1000 mg/kg, 50-500 mg/kg or 500-1000 mg/kg on a dry weight basis. Typically, the RebD-enriched composition has an undetectable amount of  Stevia  plant-derived contaminants. 
     Such a steviol glycoside composition can be a RebE-enriched composition having greater than 3 weight % RebE and be incorporated into the food product such that the amount of RebE in the product is from 25-1600 mg/kg, e.g., 100-500 mg/kg, 25-100 mg/kg, 250-1000 mg/kg, 50-500 mg/kg or 500-1000 mg/kg on a dry weight basis. Typically, the RebE-enriched composition has an undetectable amount of  Stevia  plant-derived contaminants. 
     Such a steviol glycoside composition can be a RebM-enriched composition having greater than 3 weight % RebM and be incorporated into the food product such that the amount of RebM in the product is from 25-1600 mg/kg, e.g., 100-500 mg/kg, 25-100 mg/kg, 250-1000 mg/kg, 50-500 mg/kg or 500-1000 mg/kg on a dry weight basis. Typically, the RebM-enriched composition has an undetectable amount of  Stevia  plant-derived contaminants. 
     In some embodiments, a substantially pure steviol or steviol glycoside is incorporated into a tabletop sweetener or “cup-for-cup” product. Such products typically are diluted to the appropriate sweetness level with one or more bulking agents, e.g., maltodextrins, known to those skilled in the art. Steviol glycoside compositions enriched for RebA, RebB, RebD, RebE, or RebM, can be package in a sachet, for example, at from 10,000 to 30,000 mg steviol glycoside/kg product on a dry weight basis, for tabletop use. In some embodiments, a steviol glycoside produced in vitro, in vivo, or by whole cell bioconversion. 
     The invention also provides an isolated nucleic acid molecule encoding a polypeptide or a catalytically active portion thereof capable of debranching glycogen comprising a polypeptide or a catalytically active portion thereof having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:157 or a polypeptide or a catalytically active portion thereof capable of synthesizing glucose-1-phosphate comprising a polypeptide or a catalytically active portion thereof having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:159. 
     In one aspect of the isolated nucleic acids disclosed herein, the nucleic acid is cDNA. 
     The invention also provides a polypeptide or a catalytically active portion thereof capable of debranching glycogen comprising a polypeptide or a catalytically active portion thereof having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:157 or a polypeptide or a catalytically active portion thereof capable of synthesizing glucose-1-phosphate comprising a polypeptide or a catalytically active portion thereof having at least 55% sequence identity to the amino acid sequence set forth in SEQ ID NO:159. 
     In one aspect of the polypeptides or the catalytically active portion thereof disclosed herein, the polypeptide or the catalytically active portion thereof is a purified polypeptide or a catalytically active portion thereof. 
     The invention will be further described in the following examples, which do not limit the scope of the invention described in the claims. 
     EXAMPLES 
     The Examples that follow are illustrative of specific embodiments of the invention, and various uses thereof. They are set forth for explanatory purposes only, and are not to be taken as limiting the invention. 
     Example 1: Strain Engineering 
     Steviol glycoside-producing  S. cerevisiae  strains were constructed as described in WO 2011/153378, WO 2013/022989, WO 2014/122227, and WO 2014/122328, each of which is incorporated by reference in its entirety. For example, yeast strains comprising and expressing a native gene encoding a YNK1 polypeptide (SEQ ID NO:122, SEQ ID NO:123), a native gene encoding a PGM1 polypeptide (SEQ ID NO:1, SEQ ID NO:2), a native gene encoding a PGM2 polypeptide (SEQ ID NO:118, SEQ ID NO:119), a native gene encoding a UGP1 polypeptide (SEQ ID NO:120, SEQ ID NO:121), a native gene encoding a GDB1 polypeptide (SEQ ID NO:156, SEQ ID NO:157), a native gene encoding a GPH1 polypeptide (SEQ ID NO:158, SEQ ID NO:159), a recombinant gene encoding a GGPPS polypeptide (SEQ ID NO:19, SEQ ID NO:20), a recombinant gene encoding a truncated CDPS polypeptide (SEQ ID NO:39, SEQ ID NO:40), a recombinant gene encoding a KS polypeptide (SEQ ID NO:51, SEQ ID NO:52), a recombinant gene encoding a KO polypeptide (SEQ ID NO:59, SEQ ID NO:60), a recombinant gene encoding a KO polypeptide (SEQ ID NO:63, SEQ ID NO:64), a recombinant gene encoding an ATR2 polypeptide (SEQ ID NO:91, SEQ ID NO:92), a recombinant gene encoding a KAHe1 polypeptide (SEQ ID NO:93, SEQ ID NO:94), a recombinant gene encoding a CPR8 polypeptide (SEQ ID NO:85, SEQ ID NO:86), a recombinant gene encoding a CPR1 polypeptide (SEQ ID NO:77, SEQ ID NO:78), a recombinant gene encoding a UGT76G1 polypeptide (SEQ ID NO:8, SEQ ID NO:9), a recombinant gene encoding a UGT85C2 polypeptide (SEQ ID NO:5/SEQ ID NO:6, SEQ ID NO:7), a recombinant gene encoding a UGT74G1 polypeptide (SEQ ID NO:3, SEQ ID NO:4), a recombinant gene encoding a UGT91d2e-b polypeptide (SEQ ID NO:12, SEQ ID NO:13), a recombinant gene encoding an EUGT11 polypeptide (SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16), a recombinant gene encoding a KAH polypeptide (SEQ ID NO:96, SEQ ID NO:97), a recombinant gene encoding a KO polypeptide (SEQ ID NO:117, SEQ ID NO:64), and additional copies of the gene encoding a YNK1 polypeptide (SEQ ID NO:122, SEQ ID NO:123), the gene encoding a PGM1 polypeptide (SEQ ID NO:1, SEQ ID NO:2), the gene encoding a PGM2 polypeptide (SEQ ID NO:118, SEQ ID NO:119), the gene encoding a UGP1 polypeptide (SEQ ID NO:120, SEQ ID NO:121), and the gene encoding an ERC1 transporter polypeptide (i.e., of the MATE family) (SEQ ID NO:160, SEQ ID NO:161) were engineered to accumulate steviol glycosides. 
     Example 2: Overexpression of GDB1 and GPH1 
     A steviol glycoside-producing  S. cerevisiae  strain as described in Example 1 was transformed with vectors comprising additional copies of the gene encoding a GDB1 polypeptide (SEQ ID NO:156, SEQ ID NO:157), operably linked to a TPI1 promoter (SEQ ID NO:152) and a ADH1 terminator (SEQ ID NO:155) and the gene encoding a GPH1 polypeptide (SEQ ID NO:158, SEQ ID NO:159), operably linked to a pPDC1 promoter (SEQ ID NO:153) and a tCYC1 terminator (SEQ ID NO:154). 
     Fed-batch fermentation with cultures of the transformed  S. cerevisiae  strain and a control  S. cerevisiae  strain (a steviol glycoside-producing  S. cerevisiae  strain as described in Example 1) was carried out aerobically in 2L fermenters at 30° C. with an approximate 16 h growth phase in minimal medium comprising glucose, ammonium sulfate, trace metals, vitamins, salts, and buffer followed by an approximate 100 h feeding phase with a glucose-comprising defined feed medium. A pH near 6.0 and glucose-limiting conditions were maintained. Extractions of whole culture samples (without cell removal) were performed and extracts were analyzed by LC-UV to determine levels of steviol glycosides. 
     LC-UV was conducted with an Agilent 1290 instrument comprising a variable wavelength detector (VWD), a thermostatted column compartment (TCC), an autosampler, an autosampler cooling unit, and a binary pump, using SB-C18 rapid resolution high definition (RRHD) 2.1 mm×300 mm, 1.8 μm analytical columns (two 150 mm columns in series; column temperature of 65° C.). Steviol glycosides were separated by a reversed-phase C18 column followed by detection by UV absorbance at 210 mm. Quantification of steviol glycosides was done by comparing the peak area of each analyte to standards of RebA and applying a correction factor for species with differing molar absorptivities. For LC-UV, 0.5 mL cultures were spun down, the supernatant was removed, and the wet weight of the pellets was calculated. The LC-UV results were normalized by pellet wet weight. Total steviol glycoside values of the fed-batch fermentation were calculated based upon the measured levels of steviol glycosides calculated as a sum (in g/L RebD equivalents) of measured RebA, RebB, RebD, RebE, RebM, 13-SMG, rubusoside, steviol-1,2-bioside, di-glycosylated steviol, tri-glycosylated steviol, tetra-glycosylated steviol, penta-glycosylated steviol, hexa-glycosylated steviol, and hepta-glycosylated steviol. Total flux was calculated as a sum (in g/L RebD equivalents) of measured RebA, RebB, RebD, RebE, RebM, 13-SMG, rubusoside, steviol-1,2-bioside, di-glycosylated steviol, tri-glycosylated steviol, tetra-glycosylated steviol, penta-glycosylated steviol, hexa-glycosylated steviol, hepta-glycosylated steviol, copalol, ent-kaurenoic acid, glycosylated ent-kaurenoic acid, glycosylated ent-kaurenol, ent-kaurenal, geranylgeraniol, ent-kaurenal, and ent-kaurene levels. Results are shown in Table 1. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Steviol Glycoside accumulation by transformed  S. cerevisiae   
               
               
                 strain and  S. cerevisiae  control strain. 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 RebD + 
                 Total 
                 Total 
               
               
                   
                 13-SMG 
                 RebA 
                 RebD 
                 RebM 
                 RebM 
                 SGs 
                 Flux 
               
               
                 Strains 
                 (g/L) 
                 (g/L) 
                 (g/L) 
                 (g/L) 
                 (g/L) 
                 (g/L) 
                 (g/L) 
               
               
                   
               
               
                 Control 
                 1.59 
                 0.49 
                 1.26 
                 5.91 
                 7.2 
                 11.53 
                 23.08 
               
               
                 +GDB1 
                 1.13 
                 0.53 
                 1.63 
                 6.60 
                 8.2 
                 11.60 
                 26.29 
               
               
                 +GPH1 
               
               
                 Change 
                 −29% 
                 8% 
                 29% 
                 12% 
                 14% 
                 1% 
                 14% 
               
               
                   
               
               
                 End point fermentation titer (120 h) g/L as in RebD equivalent 
               
            
           
         
       
     
     Percent change in steviol glycoside production (% increase or % decrease) was calculated as follows. The amount of a particular steviol glycoside (e.g., RebM) produced by the control strain (in g/L) was subtracted from the amount of the particular steviol glycoside produced by the experimental strain overexpressing GPH1 and GDB1 (in g/L). That resulting value was then divided by the amount of the particular steviol glycoside produced by the control strain (in g/L) and multiplied by 100. A positive number using this equation signifies a percent increase in a particular steviol glycoside produced by the strain overexpressing GPH1 and GDB1 (in g/L), whereas a negative number using this equation signifies a percent decrease in a particular steviol glycoside (e.g., 13-SMG) produced by the strain overexpressing GPH1 and GDB1 (in g/L). 
     Overexpression of GPH1 and GDB1 resulted in a 29% decrease in 13-SMG accumulation, and an increase of 8%, 29% and 12% in RebA, RebD and RebM accumulation, respectively, in comparison to the control strain. There was also a 14% increase in RebD+RebM accumulation. Furthermore, there was a 14% increase in total flux accumulated by the strain overexpressing GPH1 and GDB1 genes, compared to the control strain. The total amount of steviol glycosides accumulated changed negligibly. Without being bound by theory, the lack of a significant change in total steviol glycoside accumulation and the decrease in 13-SMG accumulation suggests that overexpression of GPH1 and GDB1 in a steviol glycoside producing recombinant host enhances the flux of glycosylation pathways towards higher molecular weight steviol glycosides, e.g. RebD and RebM, altering the production profile, rather than simply increasing steviol glycoside production, generally. 
     Having described the invention in detail and by reference to specific embodiments thereof, it will be apparent that modifications and variations are possible without departing from the scope of the invention defined in the appended claims. More specifically, although some aspects of the present invention are identified herein as particularly advantageous, it is contemplated that the present invention is not necessarily limited to these particular aspects of the invention. 
     
       
         
           
               
             
               
                 TABLE 3 
               
               
                   
               
               
                 Sequences disclosed herein. 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 1 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 atgtcacttc taatagattc tgtaccaaca gttgcttata aggaccaaaa accgggtact 
                 60 
               
               
                   
               
               
                 tcaggtttac gtaagaagac caaggttttc atggatgagc ctcattatac tgagaacttc 
                 120 
               
               
                   
               
               
                 attcaagcaa caatgcaatc tatccctaat ggctcagagg gaaccacttt agttgttgga 
                 180 
               
               
                   
               
               
                 ggagatggtc gtttctacaa cgatgttatc atgaacaaga ttgccgcagt aggtgctgca 
                 240 
               
               
                   
               
               
                 aacggtgtca gaaagttagt cattggtcaa ggcggtttac tttcaacacc agctgcttct 
                 300 
               
               
                   
               
               
                 catataatta gaacatacga ggaaaagtgt accggtggtg gtatcatatt aactgcctca 
                 360 
               
               
                   
               
               
                 cacaacccag gcggtccaga gaatgattta ggtatcaagt ataatttacc taatggtggg 
                 420 
               
               
                   
               
               
                 ccagctccag agagtgtcac taacgctatc tgggaagcgt ctaaaaaatt aactcactat 
                 480 
               
               
                   
               
               
                 aaaattataa agaacttccc caagttgaat ttgaacaagc ttggtaaaaa ccaaaaatat 
                 540 
               
               
                   
               
               
                 ggcccattgt tagtggacat aattgatcct gccaaagcat acgttcaatt tctgaaggaa 
                 600 
               
               
                   
               
               
                 atttttgatt ttgacttaat taaaagcttc ttagcgaaac agcgcaaaga caaagggtgg 
                 660 
               
               
                   
               
               
                 aagttgttgt ttgactcctt aaatggtatt acaggaccat atggtaaggc tatatttgtt 
                 720 
               
               
                   
               
               
                 gatgaatttg gtttaccggc agaggaagtt cttcaaaatt ggcacccttt acctgatttc 
                 780 
               
               
                   
               
               
                 ggcggtttac atcccgatcc gaatctaacc tatgcacgaa ctcttgttga cagggttgac 
                 840 
               
               
                   
               
               
                 cgcgaaaaaa ttgcctttgg agcagcctcc gatggtgatg gtgataggaa tatgatttac 
                 900 
               
               
                   
               
               
                 ggttatggcc ctgctttcgt ttcgccaggt gattctgttg ccattattgc cgaatatgca 
                 960 
               
               
                   
               
               
                 cccgaaattc catacttcgc caaacaaggt atttatggct tggcacgttc atttcctaca 
                 1020 
               
               
                   
               
               
                 tcctcagcca ttgatcgtgt tgcagcaaaa aagggattaa gatgttacga agttccaacc 
                 1080 
               
               
                   
               
               
                 ggctggaaat tcttctgtgc cttatttgat gctaaaaagc tatcaatctg tggtgaagaa 
                 1140 
               
               
                   
               
               
                 tccttcggta caggttccaa tcatatcaga gaaaaggacg gtctatgggc cattattgct 
                 1200 
               
               
                   
               
               
                 tggttaaata tcttggctat ctaccatagg cgtaaccctg aaaaggaagc ttcgatcaaa 
                 1260 
               
               
                   
               
               
                 actattcagg acgaattttg gaacgagtat ggccgtactt tcttcacaag atacgattac 
                 1320 
               
               
                   
               
               
                 gaacatatcg aatgcgagca ggccgaaaaa gttgtagctc ttttgagtga atttgtatca 
                 1380 
               
               
                   
               
               
                 aggccaaacg tttgtggctc ccacttccca gctgatgagt ctttaaccgt tatcgattgt 
                 1440 
               
               
                   
               
               
                 ggtgattttt cgtatagaga tctagatggc tccatctctg aaaatcaagg ccttttcgta 
                 1500 
               
               
                   
               
               
                 aagttttcga atgggactaa atttgttttg aggttatccg gcacaggcag ttctggtgca 
                 1560 
               
               
                   
               
               
                 acaataagat tatacgtaga aaagtatact gataaaaagg agaactatgg ccaaacagct 
                 1620 
               
               
                   
               
               
                 gacgtcttct tgaaacccgt catcaactcc attgtaaaat tcttaagatt taaagaaatt 
                 1680 
               
               
                   
               
               
                 ttaggaacag acgaaccaac agtccgcaca tag 
                 1713 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 2 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 MSLLIDSVPT VAYKDQKPGT SGLRKKTKVF MDEPHYTENF IQATMQSIPN GSEGTTLVVG 
                 60 
               
               
                   
               
               
                 GDGRFYNDVI MNKIAAVGAA NGVRKLVIGQ GGLLSTPAAS HIIRTYEEKC TGGGIILTAS 
                 120 
               
               
                   
               
               
                 HNPGGPENDL GIKYNLPNGG PAPESVTNAI WEASKKLTHY KIIKNFPKLN LNKLGKNQKY 
                 180 
               
               
                   
               
               
                 GPLLVDIIDP AKAYVQFLKE IFDFDLIKSF LAKQRKDKGW KLLFDSLNGI TGPYGKAIFV 
                 240 
               
               
                   
               
               
                 DEFGLPAEEV LQNWHPLPDF GGLHPDPNLT YARTLVDRVD REKIAFGAAS DGDGDRNMIY 
                 300 
               
               
                   
               
               
                 GYGPAFVSPG DSVAIIAEYA PEIPYFAKQG IYGLARSFPT SSAIDRVAAK KGLRCYEVPT 
                 360 
               
               
                   
               
               
                 GWKFFCALFD AKKLSICGEE SFGTGSNHIR EKDGLWAIIA WLNILAIYHR RNPEKEASIK 
                 420 
               
               
                   
               
               
                 TIQDEFWNEY GRTFFTRYDY EHIECEQAEK VVALLSEFVS RPNVCGSHFP ADESLTVIDC 
                 480 
               
               
                   
               
               
                 GDFSYRDLDG SISENQGLFV KFSNGTKFVL RLSGTGSSGA TIRLYVEKYT DKKENYGQTA 
                 540 
               
               
                   
               
               
                 DVFLKPVINS IVKFLRFKEI LGTDEPTVRT 
                 570 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 3 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 atggcagagc aacaaaagat caaaaagtca cctcacgtct tacttattcc atttcctctg 
                 60 
               
               
                   
               
               
                 caaggacata tcaacccatt catacaattt gggaaaagat tgattagtaa gggtgtaaag 
                 120 
               
               
                   
               
               
                 acaacactgg taaccactat ccacactttg aattctactc tgaaccactc aaatactact 
                 180 
               
               
                   
               
               
                 actacaagta tagaaattca agctatatca gacggatgcg atgagggtgg ctttatgtct 
                 240 
               
               
                   
               
               
                 gccggtgaat cttacttgga aacattcaag caagtgggat ccaagtctct ggccgatcta 
                 300 
               
               
                   
               
               
                 atcaaaaagt tacagagtga aggcaccaca attgacgcca taatctacga ttctatgaca 
                 360 
               
               
                   
               
               
                 gagtgggttt tagacgttgc tatcgaattt ggtattgatg gaggttcctt tttcacacaa 
                 420 
               
               
                   
               
               
                 gcatgtgttg tgaattctct atactaccat gtgcataaag ggttaatctc tttaccattg 
                 480 
               
               
                   
               
               
                 ggtgaaactg tttcagttcc aggttttcca gtgttacaac gttgggaaac cccattgatc 
                 540 
               
               
                   
               
               
                 ttacaaaatc atgaacaaat acaatcacct tggtcccaga tgttgtttgg tcaattcgct 
                 600 
               
               
                   
               
               
                 aacatcgatc aagcaagatg ggtctttact aattcattct ataagttaga ggaagaggta 
                 660 
               
               
                   
               
               
                 attgaatgga ctaggaagat ctggaatttg aaagtcattg gtccaacatt gccatcaatg 
                 720 
               
               
                   
               
               
                 tatttggaca aaagacttga tgatgataaa gataatggtt tcaatttgta caaggctaat 
                 780 
               
               
                   
               
               
                 catcacgaat gtatgaattg gctggatgac aaaccaaagg aatcagttgt atatgttgct 
                 840 
               
               
                   
               
               
                 ttcggctctc ttgttaaaca tggtccagaa caagttgagg agattacaag agcacttata 
                 900 
               
               
                   
               
               
                 gactctgacg taaacttttt gtgggtcatt aagcacaaag aggaggggaa actgccagaa 
                 960 
               
               
                   
               
               
                 aacctttctg aagtgataaa gaccggaaaa ggtctaatcg ttgcttggtg taaacaattg 
                 1020 
               
               
                   
               
               
                 gatgttttag ctcatgaatc tgtaggctgt tttgtaacac attgcggatt caactctaca 
                 1080 
               
               
                   
               
               
                 ctagaagcca tttccttagg cgtacctgtc gttgcaatgc ctcagttctc cgatcagaca 
                 1140 
               
               
                   
               
               
                 accaacgcta aacttttgga cgaaatacta ggggtgggtg tcagagttaa agcagacgag 
                 1200 
               
               
                   
               
               
                 aatggtatcg tcagaagagg gaacctagct tcatgtatca aaatgatcat ggaagaggaa 
                 1260 
               
               
                   
               
               
                 agaggagtta tcataaggaa aaacgcagtt aagtggaagg atcttgcaaa ggttgccgtc 
                 1320 
               
               
                   
               
               
                 catgaaggcg gctcttcaga taatgatatt gttgaatttg tgtccgaact aatcaaagcc 
                 1380 
               
               
                   
               
               
                 taa 
                 1383 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 4 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MAEQQKIKKS PHVLLIPFPL QGHINPFIQF GKRLISKGVK TTLVTTIHTL NSTLNHSNTT 
                 60 
               
               
                   
               
               
                 TTSIEIQAIS DGCDEGGFMS AGESYLETFK QVGSKSLADL IKKLQSEGTT IDAIIYDSMT 
                 120 
               
               
                   
               
               
                 EWVLDVAIEF GIDGGSFFTQ ACVVNSLYYH VHKGLISLPL GETVSVPGFP VLQRWETPLI 
                 180 
               
               
                   
               
               
                 LQNHEQIQSP WSQMLFGQFA NIDQARWVFT NSFYKLEEEV IEWTRKIWNL KVIGPTLPSM 
                 240 
               
               
                   
               
               
                 YLDKRLDDDK DNGFNLYKAN HHECMNWLDD KPKESVVYVA FGSLVKHGPE QVEEITRALI 
                 300 
               
               
                   
               
               
                 DSDVNFLWVI KHKEEGKLPE NLSEVIKTGK GLIVAWCKQL DVLAHESVGC FVTHCGFNST 
                 360 
               
               
                   
               
               
                 LEAISLGVPV VAMPQFSDQT TNAKLLDEIL GVGVRVKADE NGIVRRGNLA SCIKMIMEEE 
                 420 
               
               
                   
               
               
                 RGVIIRKNAV KWKDLAKVAV HEGGSSDNDI VEFVSELIKA 
                 460 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 5 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 atggatgcaa tggctacaac tgagaagaaa ccacacgtca tcttcatacc atttccagca 
                 60 
               
               
                   
               
               
                 caaagccaca ttaaagccat gctcaaacta gcacaacttc tccaccacaa aggactccag 
                 120 
               
               
                   
               
               
                 ataaccttcg tcaacaccga cttcatccac aaccagtttc ttgaatcatc gggcccacat 
                 180 
               
               
                   
               
               
                 tgtctagacg gtgcaccggg tttccggttc gaaaccattc cggatggtgt ttctcacagt 
                 240 
               
               
                   
               
               
                 ccggaagcga gcatcccaat cagagaatca ctcttgagat ccattgaaac caacttcttg 
                 300 
               
               
                   
               
               
                 gatcgtttca ttgatcttgt aaccaaactt ccggatcctc cgacttgtat tatctcagat 
                 360 
               
               
                   
               
               
                 gggttcttgt cggttttcac aattgacgct gcaaaaaagc ttggaattcc ggtcatgatg 
                 420 
               
               
                   
               
               
                 tattggacac ttgctgcctg tgggttcatg ggtttttacc atattcattc tctcattgag 
                 480 
               
               
                   
               
               
                 aaaggatttg caccacttaa agatgcaagt tacttgacaa atgggtattt ggacaccgtc 
                 540 
               
               
                   
               
               
                 attgattggg ttccgggaat ggaaggcatc cgtctcaagg atttcccgct ggactggagc 
                 600 
               
               
                   
               
               
                 actgacctca atgacaaagt tttgatgttc actacggaag ctcctcaaag gtcacacaag 
                 660 
               
               
                   
               
               
                 gtttcacatc atattttcca cacgttcgat gagttggagc ctagtattat aaaaactttg 
                 720 
               
               
                   
               
               
                 tcattgaggt ataatcacat ttacaccatc ggcccactgc aattacttct tgatcaaata 
                 780 
               
               
                   
               
               
                 cccgaagaga aaaagcaaac tggaattacg agtctccatg gatacagttt agtaaaagaa 
                 840 
               
               
                   
               
               
                 gaaccagagt gtttccagtg gcttcagtct aaagaaccaa attccgtcgt ttatgtaaat 
                 900 
               
               
                   
               
               
                 tttggaagta ctacagtaat gtctttagaa gacatgacgg aatttggttg gggacttgct 
                 960 
               
               
                   
               
               
                 aatagcaacc attatttcct ttggatcatc cgatcaaact tggtgatagg ggaaaatgca 
                 1020 
               
               
                   
               
               
                 gttttgcccc ctgaacttga ggaacatata aagaaaagag gctttattgc tagctggtgt 
                 1080 
               
               
                   
               
               
                 tcacaagaaa aggtcttgaa gcacccttcg gttggagggt tcttgactca ttgtgggtgg 
                 1140 
               
               
                   
               
               
                 ggatcgacca tcgagagctt gtctgctggg gtgccaatga tatgctggcc ttattcgtgg 
                 1200 
               
               
                   
               
               
                 gaccagctga ccaactgtag gtatatatgc aaagaatggg aggttgggct cgagatggga 
                 1260 
               
               
                   
               
               
                 accaaagtga aacgagatga agtcaagagg cttgtacaag agttgatggg agaaggaggt 
                 1320 
               
               
                   
               
               
                 cacaaaatga ggaacaaggc taaagattgg aaagaaaagg ctcgcattgc aatagctcct 
                 1380 
               
               
                   
               
               
                 aacggttcat cttctttgaa catagacaaa atggtcaagg aaatcaccgt gctagcaaga 
                 1440 
               
               
                   
               
               
                 aactagttac aaagttgttt cacattgtgc tttctattta agatgtaact ttgttctaat 
                 1500 
               
               
                   
               
               
                 ttaatattgt ctagatgtat tgaaccataa gtttagttgg tctcaggaat tgatttttaa 
                 1560 
               
               
                   
               
               
                 tgaaataatg gtcattaggg gtgagt 
                 1586 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 6 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggatgcaa tggcaactac tgagaaaaag cctcatgtga tcttcattcc atttcctgca 
                 60 
               
               
                   
               
               
                 caatctcaca taaaggcaat gctaaagtta gcacaactat tacaccataa gggattacag 
                 120 
               
               
                   
               
               
                 ataactttcg tgaataccga cttcatccat aatcaatttc tggaatctag tggccctcat 
                 180 
               
               
                   
               
               
                 tgtttggacg gagccccagg gtttagattc gaaacaattc ctgacggtgt ttcacattcc 
                 240 
               
               
                   
               
               
                 ccagaggcct ccatcccaat aagagagagt ttactgaggt caatagaaac caactttttg 
                 300 
               
               
                   
               
               
                 gatcgtttca ttgacttggt cacaaaactt ccagacccac caacttgcat aatctctgat 
                 360 
               
               
                   
               
               
                 ggctttctgt cagtgtttac tatcgacgct gccaaaaagt tgggtatccc agttatgatg 
                 420 
               
               
                   
               
               
                 tactggactc ttgctgcatg cggtttcatg ggtttctatc acatccattc tcttatcgaa 
                 480 
               
               
                   
               
               
                 aagggttttg ctccactgaa agatgcatca tacttaacca acggctacct ggatactgtt 
                 540 
               
               
                   
               
               
                 attgactggg taccaggtat ggaaggtata agacttaaag attttccttt ggattggtct 
                 600 
               
               
                   
               
               
                 acagacctta atgataaagt attgatgttt actacagaag ctccacaaag atctcataag 
                 660 
               
               
                   
               
               
                 gtttcacatc atatctttca cacctttgat gaattggaac catcaatcat caaaaccttg 
                 720 
               
               
                   
               
               
                 tctctaagat acaatcatat ctacactatt ggtccattac aattacttct agatcaaatt 
                 780 
               
               
                   
               
               
                 cctgaagaga aaaagcaaac tggtattaca tccttacacg gctactcttt agtgaaagag 
                 840 
               
               
                   
               
               
                 gaaccagaat gttttcaatg gctacaaagt aaagagccta attctgtggt ctacgtcaac 
                 900 
               
               
                   
               
               
                 ttcggaagta caacagtcat gtccttggaa gatatgactg aatttggttg gggccttgct 
                 960 
               
               
                   
               
               
                 aattcaaatc attactttct atggattatc aggtccaatt tggtaatagg ggaaaacgcc 
                 1020 
               
               
                   
               
               
                 gtattacctc cagaattgga ggaacacatc aaaaagagag gtttcattgc ttcctggtgt 
                 1080 
               
               
                   
               
               
                 tctcaggaaa aggtattgaa acatccttct gttggtggtt tccttactca ttgcggttgg 
                 1140 
               
               
                   
               
               
                 ggctctacaa tcgaatcact aagtgcagga gttccaatga tttgttggcc atattcatgg 
                 1200 
               
               
                   
               
               
                 gaccaactta caaattgtag gtatatctgt aaagagtggg aagttggatt agaaatggga 
                 1260 
               
               
                   
               
               
                 acaaaggtta aacgtgatga agtgaaaaga ttggttcagg agttgatggg ggaaggtggc 
                 1320 
               
               
                   
               
               
                 cacaagatga gaaacaaggc caaagattgg aaggaaaaag ccagaattgc tattgctcct 
                 1380 
               
               
                   
               
               
                 aacgggtcat cctctctaaa cattgataag atggtcaaag agattacagt cttagccaga 
                 1440 
               
               
                   
               
               
                 aactaa 
                 1446 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 7 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MDAMATTEKK PHVIFIPFPA QSHIKAMLKL AQLLHHKGLQ ITFVNTDFIH NQFLESSGPH 
                 60 
               
               
                   
               
               
                 CLDGAPGFRF ETIPDGVSHS PEASIPIRES LLRSIETNFL DRFIDLVTKL PDPPTCIISD 
                 120 
               
               
                   
               
               
                 GFLSVFTIDA AKKLGIPVMM YWTLAACGFM GFYHIHSLIE KGFAPLKDAS YLTNGYLDTV 
                 180 
               
               
                   
               
               
                 IDWVPGMEGI RLKDFPLDWS TDLNDKVLMF TTEAPQRSHK VSHHIFHTFD ELEPSIIKTL 
                 240 
               
               
                   
               
               
                 SLRYNHIYTI GPLQLLLDQI PEEKKQTGIT SLHGYSLVKE EPECFQWLQS KEPNSVVYVN 
                 300 
               
               
                   
               
               
                 FGSTTVMSLE DMTEFGWGLA NSNHYFLWII RSNLVIGENA VLPPELEEHI KKRGFIASWC 
                 360 
               
               
                   
               
               
                 SQEKVLKHPS VGGFLTHCGW GSTIESLSAG VPMICWPYSW DQLTNCRYIC KEWEVGLEMG 
                 420 
               
               
                   
               
               
                 TKVKRDEVKR LVQELMGEGG HKMRNKAKDW KEKARIAIAP NGSSSLNIDK MVKEITVLAR 
                 480 
               
               
                   
               
               
                 N 
                 481 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 8 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggaaaaca agaccgaaac aacagttaga cgtaggcgta gaatcattct gtttccagta 
                 60 
               
               
                   
               
               
                 ccttttcaag ggcacatcaa tccaatacta caactagcca acgttttgta ctctaaaggt 
                 120 
               
               
                   
               
               
                 ttttctatta caatctttca caccaatttc aacaaaccaa aaacatccaa ttacccacat 
                 180 
               
               
                   
               
               
                 ttcacattca gattcatact tgataatgat ccacaagatg aacgtatttc aaacttacct 
                 240 
               
               
                   
               
               
                 acccacggtc ctttagctgg aatgagaatt ccaatcatca atgaacatgg tgccgatgag 
                 300 
               
               
                   
               
               
                 cttagaagag aattagagtt acttatgttg gcatccgaag aggacgagga agtctcttgt 
                 360 
               
               
                   
               
               
                 ctgattactg acgctctatg gtactttgcc caatctgtgg ctgatagttt gaatttgagg 
                 420 
               
               
                   
               
               
                 agattggtac taatgacatc cagtctgttt aactttcacg ctcatgttag tttaccacaa 
                 480 
               
               
                   
               
               
                 tttgacgaat tgggatactt ggaccctgat gacaagacta ggttagagga acaggcctct 
                 540 
               
               
                   
               
               
                 ggttttccta tgttgaaagt caaagatatc aagtctgcct attctaattg gcaaatcttg 
                 600 
               
               
                   
               
               
                 aaagagatct taggaaagat gatcaaacag acaaaggctt catctggagt gatttggaac 
                 660 
               
               
                   
               
               
                 agtttcaaag agttagaaga gtctgaattg gagactgtaa tcagagaaat tccagcacct 
                 720 
               
               
                   
               
               
                 tcattcctga taccattacc aaaacatttg actgcttcct cttcctcttt gttggatcat 
                 780 
               
               
                   
               
               
                 gacagaacag tttttcaatg gttggaccaa caaccaccta gttctgtttt gtacgtgtca 
                 840 
               
               
                   
               
               
                 tttggtagta cttctgaagt cgatgaaaag gacttccttg aaatcgcaag aggcttagtc 
                 900 
               
               
                   
               
               
                 gatagtaagc agtcattcct ttgggtcgtg cgtccaggtt tcgtgaaagg ctcaacatgg 
                 960 
               
               
                   
               
               
                 gtcgaaccac ttccagatgg ttttctaggc gaaagaggta gaatagtcaa atgggttcct 
                 1020 
               
               
                   
               
               
                 caacaggaag ttttagctca tggcgctatt ggggcattct ggactcattc cggatggaat 
                 1080 
               
               
                   
               
               
                 tcaactttag aatcagtatg cgaaggggta cctatgatct tttcagattt tggtcttgat 
                 1140 
               
               
                   
               
               
                 caaccactga acgcaagata catgtctgat gttttgaaag tgggtgtata tctagaaaat 
                 1200 
               
               
                   
               
               
                 ggctgggaaa ggggtgaaat agctaatgca ataagacgtg ttatggttga tgaagagggg 
                 1260 
               
               
                   
               
               
                 gagtatatca gacaaaacgc aagagtgctg aagcaaaagg ccgacgtttc tctaatgaag 
                 1320 
               
               
                   
               
               
                 ggaggctctt catacgaatc cttagaatct cttgtttcct acatttcatc actgtaa 
                 1377 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 9 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MENKTETTVR RRRRIILFPV PFQGHINPIL QLANVLYSKG FSITIFHTNF NKPKTSNYPH 
                 60 
               
               
                   
               
               
                 FTFRFILDND PQDERISNLP THGPLAGMRI PIINEHGADE LRRELELLML ASEEDEEVSC 
                 120 
               
               
                   
               
               
                 LITDALWYFA QSVADSLNLR RLVLMTSSLF NFHAHVSLPQ FDELGYLDPD DKTRLEEQAS 
                 180 
               
               
                   
               
               
                 GFPMLKVKDI KSAYSNWQIL KEILGKMIKQ TKASSGVIWN SFKELEESEL ETVIREIPAP 
                 240 
               
               
                   
               
               
                 SFLIPLPKHL TASSSSLLDH DRTVFQWLDQ QPPSSVLYVS FGSTSEVDEK DFLEIARGLV 
                 300 
               
               
                   
               
               
                 DSKQSFLWVV RPGFVKGSTW VEPLPDGFLG ERGRIVKWVP QQEVLAHGAI GAFWTHSGWN 
                 360 
               
               
                   
               
               
                 STLESVCEGV PMIFSDFGLD QPLNARYMSD VLKVGVYLEN GWERGEIANA IRRVMVDEEG 
                 420 
               
               
                   
               
               
                 EYIRQNARVL KQKADVSLMK GGSSYESLES LVSYISSL 
                 458 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 10 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggctacat ctgattctat tgttgatgac aggaagcagt tgcatgtggc tactttccct 
                 60 
               
               
                   
               
               
                 tggcttgctt tcggtcatat actgccttac ctacaactat caaaactgat agctgaaaaa 
                 120 
               
               
                   
               
               
                 ggacataaag tgtcattcct ttcaacaact agaaacattc aaagattatc ttcccacata 
                 180 
               
               
                   
               
               
                 tcaccattga ttaacgtcgt tcaattgaca cttccaagag tacaggaatt accagaagat 
                 240 
               
               
                   
               
               
                 gctgaagcta caacagatgt gcatcctgaa gatatccctt acttgaaaaa ggcatccgat 
                 300 
               
               
                   
               
               
                 ggattacagc ctgaggtcac tagattcctt gagcaacaca gtccagattg gatcatatac 
                 360 
               
               
                   
               
               
                 gactacactc actattggtt gccttcaatt gcagcatcac taggcatttc tagggcacat 
                 420 
               
               
                   
               
               
                 ttcagtgtaa ccacaccttg ggccattgct tacatgggtc catccgctga tgctatgatt 
                 480 
               
               
                   
               
               
                 aacggcagtg atggtagaac taccgttgaa gatttgacaa ccccaccaaa gtggtttcca 
                 540 
               
               
                   
               
               
                 tttccaacta aagtctgttg gagaaaacac gacttagcaa gactggttcc atacaaggca 
                 600 
               
               
                   
               
               
                 ccaggaatct cagacggcta tagaatgggt ttagtcctta aagggtctga ctgcctattg 
                 660 
               
               
                   
               
               
                 tctaagtgtt accatgagtt tgggacacaa tggctaccac ttttggaaac attacaccaa 
                 720 
               
               
                   
               
               
                 gttcctgtcg taccagttgg tctattacct ccagaaatcc ctggtgatga gaaggacgag 
                 780 
               
               
                   
               
               
                 acttgggttt caatcaaaaa gtggttagac gggaagcaaa aaggctcagt ggtatatgtg 
                 840 
               
               
                   
               
               
                 gcactgggtt ccgaagtttt agtatctcaa acagaagttg tggaacttgc cttaggtttg 
                 900 
               
               
                   
               
               
                 gaactatctg gattgccatt tgtctgggcc tacagaaaac caaaaggccc tgcaaagtcc 
                 960 
               
               
                   
               
               
                 gattcagttg aattgccaga cggctttgtc gagagaacta gagatagagg gttggtatgg 
                 1020 
               
               
                   
               
               
                 acttcatggg ctccacaatt gagaatcctg agtcacgaat ctgtgtgcgg tttcctaaca 
                 1080 
               
               
                   
               
               
                 cattgtggtt ctggttctat agttgaagga ctgatgtttg gtcatccact tatcatgttg 
                 1140 
               
               
                   
               
               
                 ccaatctttg gtgaccagcc tttgaatgca cgtctgttag aagataaaca agttggaatt 
                 1200 
               
               
                   
               
               
                 gaaatcccac gtaatgagga agatggatgt ttaaccaagg agtctgtggc cagatcatta 
                 1260 
               
               
                   
               
               
                 cgttccgttg tcgttgaaaa ggaaggcgaa atctacaagg ccaatgcccg tgaactttca 
                 1320 
               
               
                   
               
               
                 aagatctaca atgacacaaa agtagagaag gaatatgttt ctcaatttgt agattaccta 
                 1380 
               
               
                   
               
               
                 gagaaaaacg ctagagccgt agctattgat catgaatcct aa 
                 1422 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 11 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MATSDSIVDD RKQLHVATFP WLAFGHILPY LQLSKLIAEK GHKVSFLSTT RNIQRLSSHI 
                 60 
               
               
                   
               
               
                 SPLINVVQLT LPRVQELPED AEATTDVHPE DIPYLKKASD GLQPEVTRFL EQHSPDWIIY 
                 120 
               
               
                   
               
               
                 DYTHYWLPSI AASLGISRAH FSVTTPWAIA YMGPSADAMI NGSDGRTTVE DLTTPPKWFP 
                 180 
               
               
                   
               
               
                 FPTKVCWRKH DLARLVPYKA PGISDGYRMG LVLKGSDCLL SKCYHEFGTQ WLPLLETLHQ 
                 240 
               
               
                   
               
               
                 VPVVPVGLLP PEIPGDEKDE TWVSIKKWLD GKQKGSVVYV ALGSEVLVSQ TEVVELALGL 
                 300 
               
               
                   
               
               
                 ELSGLPFVWA YRKPKGPAKS DSVELPDGFV ERTRDRGLVW TSWAPQLRIL SHESVCGFLT 
                 360 
               
               
                   
               
               
                 HCGSGSIVEG LMFGHPLIML PIFGDQPLNA RLLEDKQVGI EIPRNEEDGC LTKESVARSL 
                 420 
               
               
                   
               
               
                 RSVVVEKEGE IYKANARELS KIYNDTKVEK EYVSQFVDYL EKNARAVAID HES 
                 473 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 12 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggctactt ctgattccat cgttgacgat agaaagcaat tgcatgttgc tacttttcca 
                 60 
               
               
                   
               
               
                 tggttggctt tcggtcatat tttgccatac ttgcaattgt ccaagttgat tgctgaaaag 
                 120 
               
               
                   
               
               
                 ggtcacaagg tttcattctt gtctaccacc agaaacatcc aaagattgtc ctctcatatc 
                 180 
               
               
                   
               
               
                 tccccattga tcaacgttgt tcaattgact ttgccaagag tccaagaatt gccagaagat 
                 240 
               
               
                   
               
               
                 gctgaagcta ctactgatgt tcatccagaa gatatccctt acttgaaaaa ggcttccgat 
                 300 
               
               
                   
               
               
                 ggtttacaac cagaagttac tagattcttg gaacaacatt ccccagattg gatcatctac 
                 360 
               
               
                   
               
               
                 gattatactc attactggtt gccatccatt gctgcttcat tgggtatttc tagagcccat 
                 420 
               
               
                   
               
               
                 ttctctgtta ctactccatg ggctattgct tatatgggtc catctgctga tgctatgatt 
                 480 
               
               
                   
               
               
                 aacggttctg atggtagaac taccgttgaa gatttgacta ctccaccaaa gtggtttcca 
                 540 
               
               
                   
               
               
                 tttccaacaa aagtctgttg gagaaaacac gatttggcta gattggttcc atacaaagct 
                 600 
               
               
                   
               
               
                 ccaggtattt ctgatggtta cagaatgggt atggttttga aaggttccga ttgcttgttg 
                 660 
               
               
                   
               
               
                 tctaagtgct atcatgaatt cggtactcaa tggttgcctt tgttggaaac attgcatcaa 
                 720 
               
               
                   
               
               
                 gttccagttg ttccagtagg tttgttgcca ccagaaattc caggtgacga aaaagacgaa 
                 780 
               
               
                   
               
               
                 acttgggttt ccatcaaaaa gtggttggat ggtaagcaaa agggttctgt tgtttatgtt 
                 840 
               
               
                   
               
               
                 gctttgggtt ccgaagcttt ggtttctcaa accgaagttg ttgaattggc tttgggtttg 
                 900 
               
               
                   
               
               
                 gaattgtctg gtttgccatt tgtttgggct tacagaaaac ctaaaggtcc agctaagtct 
                 960 
               
               
                   
               
               
                 gattctgttg aattgccaga tggtttcgtt gaaagaacta gagatagagg tttggtttgg 
                 1020 
               
               
                   
               
               
                 acttcttggg ctccacaatt gagaattttg tctcatgaat ccgtctgtgg tttcttgact 
                 1080 
               
               
                   
               
               
                 cattgtggtt ctggttctat cgttgaaggt ttgatgtttg gtcacccatt gattatgttg 
                 1140 
               
               
                   
               
               
                 ccaatctttg gtgaccaacc attgaacgct agattattgg aagataagca agtcggtatc 
                 1200 
               
               
                   
               
               
                 gaaatcccaa gaaatgaaga agatggttgc ttgaccaaag aatctgttgc tagatctttg 
                 1260 
               
               
                   
               
               
                 agatccgttg tcgttgaaaa agaaggtgaa atctacaagg ctaacgctag agaattgtcc 
                 1320 
               
               
                   
               
               
                 aagatctaca acgataccaa ggtcgaaaaa gaatacgttt cccaattcgt tgactacttg 
                 1380 
               
               
                   
               
               
                 gaaaagaatg ctagagctgt tgccattgat catgaatctt ga 
                 1422 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 13 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 MATSDSIVDD RKQLHVATFP WLAFGHILPY LQLSKLIAEK GHKVSFLSTT RNIQRLSSHI 
                 60 
               
               
                   
               
               
                 SPLINVVQLT LPRVQELPED AEATTDVHPE DIPYLKKASD GLQPEVTRFL EQHSPDWIIY 
                 120 
               
               
                   
               
               
                 DYTHYWLPSI AASLGISRAH FSVTTPWAIA YMGPSADAMI NGSDGRTTVE DLTTPPKWFP 
                 180 
               
               
                   
               
               
                 FPTKVCWRKH DLARLVPYKA PGISDGYRMG MVLKGSDCLL SKCYHEFGTQ WLPLLETLHQ 
                 240 
               
               
                   
               
               
                 VPVVPVGLLP PEIPGDEKDE TWVSIKKWLD GKQKGSVVYV ALGSEALVSQ TEVVELALGL 
                 300 
               
               
                   
               
               
                 ELSGLPFVWA YRKPKGPAKS DSVELPDGFV ERTRDRGLVW TSWAPQLRIL SHESVCGFLT 
                 360 
               
               
                   
               
               
                 HCGSGSIVEG LMFGHPLIML PIFGDQPLNA RLLEDKQVGI EIPRNEEDGC LTKESVARSL 
                 420 
               
               
                   
               
               
                 RSVVVEKEGE IYKANARELS KIYNDTKVEK EYVSQFVDYL EKNARAVAID HES 
                 473 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 14 
               
               
                 
                   O. sativa 
                 
               
            
           
           
               
               
            
               
                 atggactccg gctactcctc ctcctacgcc gccgccgccg ggatgcacgt cgtgatctgc 
                 60 
               
               
                   
               
               
                 ccgtggctcg ccttcggcca cctgctcccg tgcctcgacc tcgcccagcg cctcgcgtcg 
                 120 
               
               
                   
               
               
                 cggggccacc gcgtgtcgtt cgtctccacg ccgcggaaca tatcccgcct cccgccggtg 
                 180 
               
               
                   
               
               
                 cgccccgcgc tcgcgccgct cgtcgccttc gtggcgctgc cgctcccgcg cgtcgagggg 
                 240 
               
               
                   
               
               
                 ctccccgacg gcgccgagtc caccaacgac gtcccccacg acaggccgga catggtcgag 
                 300 
               
               
                   
               
               
                 ctccaccgga gggccttcga cgggctcgcc gcgcccttct cggagttctt gggcaccgcg 
                 360 
               
               
                   
               
               
                 tgcgccgact gggtcatcgt cgacgtcttc caccactggg ccgcagccgc cgctctcgag 
                 420 
               
               
                   
               
               
                 cacaaggtgc catgtgcaat gatgttgttg ggctctgcac atatgatcgc ttccatagca 
                 480 
               
               
                   
               
               
                 gacagacggc tcgagcgcgc ggagacagag tcgcctgcgg ctgccgggca gggacgccca 
                 540 
               
               
                   
               
               
                 gcggcggcgc caacgttcga ggtggcgagg atgaagttga tacgaaccaa aggctcatcg 
                 600 
               
               
                   
               
               
                 ggaatgtccc tcgccgagcg cttctccttg acgctctcga ggagcagcct cgtcgtcggg 
                 660 
               
               
                   
               
               
                 cggagctgcg tggagttcga gccggagacc gtcccgctcc tgtcgacgct ccgcggtaag 
                 720 
               
               
                   
               
               
                 cctattacct tccttggcct tatgccgccg ttgcatgaag gccgccgcga ggacggcgag 
                 780 
               
               
                   
               
               
                 gatgccaccg tccgctggct cgacgcgcag ccggccaagt ccgtcgtgta cgtcgcgcta 
                 840 
               
               
                   
               
               
                 ggcagcgagg tgccactggg agtggagaag gtccacgagc tcgcgctcgg gctggagctc 
                 900 
               
               
                   
               
               
                 gccgggacgc gcttcctctg ggctcttagg aagcccactg gcgtctccga cgccgacctc 
                 960 
               
               
                   
               
               
                 ctccccgccg gcttcgagga gcgcacgcgc ggccgcggcg tcgtggcgac gagatgggtt 
                 1020 
               
               
                   
               
               
                 cctcagatga gcatactggc gcacgccgcc gtgggcgcgt tcctgaccca ctgcggctgg 
                 1080 
               
               
                   
               
               
                 aactcgacca tcgaggggct catgttcggc cacccgctta tcatgctgcc gatcttcggc 
                 1140 
               
               
                   
               
               
                 gaccagggac cgaacgcgcg gctaatcgag gcgaagaacg ccggattgca ggtggcaaga 
                 1200 
               
               
                   
               
               
                 aacgacggcg atggatcgtt cgaccgagaa ggcgtcgcgg cggcgattcg tgcagtcgcg 
                 1260 
               
               
                   
               
               
                 gtggaggaag aaagcagcaa agtgtttcaa gccaaagcca agaagctgca ggagatcgtc 
                 1320 
               
               
                   
               
               
                 gcggacatgg cctgccatga gaggtacatc gacggattca ttcagcaatt gagatcttac 
                 1380 
               
               
                   
               
               
                 aaggattga 
                 1389 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 15 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggatagtg gctactcctc atcttatgct gctgccgctg gtatgcacgt tgtgatctgc 
                 60 
               
               
                   
               
               
                 ccttggttgg cctttggtca cctgttacca tgtctggatt tagcccaaag actggcctca 
                 120 
               
               
                   
               
               
                 agaggccata gagtatcatt tgtgtctact cctagaaata tctctcgttt accaccagtc 
                 180 
               
               
                   
               
               
                 agacctgctc tagctcctct agttgcattc gttgctcttc cacttccaag agtagaagga 
                 240 
               
               
                   
               
               
                 ttgccagacg gcgctgaatc tactaatgac gtaccacatg atagacctga catggtcgaa 
                 300 
               
               
                   
               
               
                 ttgcatagaa gagcctttga tggattggca gctccatttt ctgagttcct gggcacagca 
                 360 
               
               
                   
               
               
                 tgtgcagact gggttatagt cgatgtattt catcactggg ctgctgcagc cgcattggaa 
                 420 
               
               
                   
               
               
                 cataaggtgc cttgtgctat gatgttgtta gggtcagcac acatgatcgc atccatagct 
                 480 
               
               
                   
               
               
                 gatagaagat tggaaagagc tgaaacagaa tccccagccg cagcaggaca aggtaggcca 
                 540 
               
               
                   
               
               
                 gctgccgccc caacctttga agtggctaga atgaaattga ttcgtactaa aggtagttca 
                 600 
               
               
                   
               
               
                 gggatgagtc ttgctgaaag gttttctctg acattatcta gatcatcatt agttgtaggt 
                 660 
               
               
                   
               
               
                 agatcctgcg tcgagttcga acctgaaaca gtacctttac tatctacttt gagaggcaaa 
                 720 
               
               
                   
               
               
                 cctattactt tccttggtct aatgcctcca ttacatgaag gaaggagaga agatggtgaa 
                 780 
               
               
                   
               
               
                 gatgctactg ttaggtggtt agatgcccaa cctgctaagt ctgttgttta cgttgcattg 
                 840 
               
               
                   
               
               
                 ggttctgagg taccactagg ggtggaaaag gtgcatgaat tagcattagg acttgagctg 
                 900 
               
               
                   
               
               
                 gccggaacaa gattcctttg ggctttgaga aaaccaaccg gtgtttctga cgccgacttg 
                 960 
               
               
                   
               
               
                 ctaccagctg ggttcgaaga gagaacaaga ggccgtggtg tcgttgctac tagatgggtc 
                 1020 
               
               
                   
               
               
                 ccacaaatga gtattctagc tcatgcagct gtaggggcct ttctaaccca ttgcggttgg 
                 1080 
               
               
                   
               
               
                 aactcaacaa tagaaggact gatgtttggt catccactta ttatgttacc aatctttggc 
                 1140 
               
               
                   
               
               
                 gatcagggac ctaacgcaag attgattgag gcaaagaacg caggtctgca ggttgcacgt 
                 1200 
               
               
                   
               
               
                 aatgatggtg atggttcctt tgatagagaa ggcgttgcag ctgccatcag agcagtcgcc 
                 1260 
               
               
                   
               
               
                 gttgaggaag agtcatctaa agttttccaa gctaaggcca aaaaattaca agagattgtg 
                 1320 
               
               
                   
               
               
                 gctgacatgg cttgtcacga aagatacatc gatggtttca tccaacaatt gagaagttat 
                 1380 
               
               
                   
               
               
                 aaagactaa 
                 1389 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 16 
               
               
                 
                   O. sativa 
                 
               
            
           
           
               
               
            
               
                 MDSGYSSSYA AAAGMHVVIC PWLAFGHLLP CLDLAQRLAS RGHRVSFVST PRNISRLPPV 
                 60 
               
               
                   
               
               
                 RPALAPLVAF VALPLPRVEG LPDGAESTND VPHDRPDMVE LHRRAFDGLA APFSEFLGTA 
                 120 
               
               
                   
               
               
                 CADWVIVDVF HHWAAAAALE HKVPCAMMLL GSAHMIASIA DRRLERAETE SPAAAGQGRP 
                 180 
               
               
                   
               
               
                 AAAPTFEVAR MKLIRTKGSS GMSLAERFSL TLSRSSLVVG RSCVEFEPET VPLLSTLRGK 
                 240 
               
               
                   
               
               
                 PITFLGLMPP LHEGRREDGE DATVRWLDAQ PAKSVVYVAL GSEVPLGVEK VHELALGLEL 
                 300 
               
               
                   
               
               
                 AGTRFLWALR KPTGVSDADL LPAGFEERTR GRGVVATRWV PQMSILAHAA VGAFLTHCGW 
                 360 
               
               
                   
               
               
                 NSTIEGLMFG HPLIMLPIFG DQGPNARLIE AKNAGLQVAR NDGDGSFDRE GVAAAIRAVA 
                 420 
               
               
                   
               
               
                 VEEESSKVFQ AKAKKLQEIV ADMACHERYI DGFIQQLRSY KD 
                 462 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 17 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 MDSGYSSSYA AAAGMHVVIC PWLAFGHLLP CLDLAQRLAS RGHRVSFVST PRNISRLPPV 
                 60 
               
               
                   
               
               
                 RPALAPLVAF VALPLPRVEG LPDGAESTND VPHDRPDMVE LHRRAFDGLA APFSEFLGTA 
                 120 
               
               
                   
               
               
                 CADWVIVDVF HHWAAAAALE HKVPCAMMLL GSAHMIASIA DRRLERAETE SPAAAGQGRP 
                 180 
               
               
                   
               
               
                 AAAPTFEVAR MKLIRTKGSS GMSLAERFSL TLSRSSLVVG RSCVEFEPET VPLLSTLRGK 
                 240 
               
               
                   
               
               
                 PITFLGLLPP EIPGDEKDET WVSIKKWLDG KQKGSVVYVA LGSEALVSQT EVVELALGLE 
                 300 
               
               
                   
               
               
                 LSGLPFVWAY RKPKGPAKSD SVELPDGFVE RTRDRGLVWT SWAPQLRILS HESVCGFLTH 
                 360 
               
               
                   
               
               
                 CGSGSIVEGL MFGHPLIMLP IFGDQPLNAR LLEDKQVGIE IARNDGDGSF DREGVAAAIR 
                 420 
               
               
                   
               
               
                 AVAVEEESSK VFQAKAKKLQ EIVADMACHE RYIDGFIQQL RSYKD 
                 465 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 18 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 MATSDSIVDD RKQLHVATFP WLAFGHILPY LQLSKLIAEK GHKVSFLSTT RNIQRLSSHI 
                 60 
               
               
                   
               
               
                 SPLINVVQLT LPRVQELPED AEATTDVHPE DIPYLKKASD GLQPEVTRFL EQHSPDWIIY 
                 120 
               
               
                   
               
               
                 DYTHYWLPSI AASLGISRAH FSVTTPWAIA YMGPSADAMI NGSDGRTTVE DLTTPPKWFP 
                 180 
               
               
                   
               
               
                 FPTKVCWRKH DLARLVPYKA PGISDGYRMG MVLKGSDCLL SKCYHEFGTQ WLPLLETLHQ 
                 240 
               
               
                   
               
               
                 VPVVPVGLMP PLHEGRREDG EDATVRWLDA QPAKSVVYVA LGSEVPLGVE KVHELALGLE 
                 300 
               
               
                   
               
               
                 LAGTRFLWAL RKPTGVSDAD LLPAGFEERT RGRGVVATRW VPQMSILAHA AVGAFLTHCG 
                 360 
               
               
                   
               
               
                 WNSTIEGLMF GHPLIMLPIF GDQGPNARLI EAKNAGLQVP RNEEDGCLTK ESVARSLRSV 
                 420 
               
               
                   
               
               
                 VVEKEGEIYK ANARELSKIY NDTKVEKEYV SQFVDYLEKN ARAVAIDHES 
                 470 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 19 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggctttgg taaacccaac cgctcttttc tatggtacct ctatcagaac aagacctaca 
                 60 
               
               
                   
               
               
                 aacttactaa atccaactca aaagctaaga ccagtttcat catcttcctt accttctttc 
                 120 
               
               
                   
               
               
                 tcatcagtta gtgcgattct tactgaaaaa catcaatcta atccttctga gaacaacaat 
                 180 
               
               
                   
               
               
                 ttgcaaactc atctagaaac tcctttcaac tttgatagtt atatgttgga aaaagtcaac 
                 240 
               
               
                   
               
               
                 atggttaacg aggcgcttga tgcatctgtc ccactaaaag acccaatcaa aatccatgaa 
                 300 
               
               
                   
               
               
                 tccatgagat actctttatt ggcaggcggt aagagaatca gaccaatgat gtgtattgca 
                 360 
               
               
                   
               
               
                 gcctgcgaaa tagtcggagg taatatcctt aacgccatgc cagccgcatg tgccgtggaa 
                 420 
               
               
                   
               
               
                 atgattcata ctatgtcttt ggtgcatgac gatcttccat gtatggataa tgatgacttc 
                 480 
               
               
                   
               
               
                 agaagaggta aacctatttc acacaaggtc tacggggagg aaatggcagt attgaccggc 
                 540 
               
               
                   
               
               
                 gatgctttac taagtttatc tttcgaacat atagctactg ctacaaaggg tgtatcaaag 
                 600 
               
               
                   
               
               
                 gatagaatcg tcagagctat aggggagttg gcccgttcag ttggctccga aggtttagtg 
                 660 
               
               
                   
               
               
                 gctggacaag ttgtagatat cttgtcagag ggtgctgatg ttggattaga tcacctagaa 
                 720 
               
               
                   
               
               
                 tacattcaca tccacaaaac agcaatgttg cttgagtcct cagtagttat tggcgctatc 
                 780 
               
               
                   
               
               
                 atgggaggag gatctgatca gcagatcgaa aagttgagaa aattcgctag atctattggt 
                 840 
               
               
                   
               
               
                 ctactattcc aagttgtgga tgacattttg gatgttacaa aatctaccga agagttgggg 
                 900 
               
               
                   
               
               
                 aaaacagctg gtaaggattt gttgacagat aagacaactt acccaaagtt gttaggtata 
                 960 
               
               
                   
               
               
                 gaaaagtcca gagaatttgc cgaaaaactt aacaaggaag cacaagagca attaagtggc 
                 1020 
               
               
                   
               
               
                 tttgatagac gtaaggcagc tcctttgatc gcgttagcca actacaatgc gtaccgtcaa 
                 1080 
               
               
                   
               
               
                 aattga 
                 1086 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 20 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MALVNPTALF YGTSIRTRPT NLLNPTQKLR PVSSSSLPSF SSVSAILTEK HQSNPSENNN 
                 60 
               
               
                   
               
               
                 LQTHLETPFN FDSYMLEKVN MVNEALDASV PLKDPIKIHE SMRYSLLAGG KRIRPMMCIA 
                 120 
               
               
                   
               
               
                 ACEIVGGNIL NAMPAACAVE MIHTMSLVHD DLPCMDNDDF RRGKPISHKV YGEEMAVLTG 
                 180 
               
               
                   
               
               
                 DALLSLSFEH IATATKGVSK DRIVRAIGEL ARSVGSEGLV AGQVVDILSE GADVGLDHLE 
                 240 
               
               
                   
               
               
                 YIHIHKTAML LESSVVIGAI MGGGSDQQIE KLRKFARSIG LLFQVVDDIL DVTKSTEELG 
                 300 
               
               
                   
               
               
                 KTAGKDLLTD KTTYPKLLGI EKSREFAEKL NKEAQEQLSG FDRRKAAPLI ALANYNAYRQ 
                 360 
               
               
                   
               
               
                 N 
                 361 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 21 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggctgagc aacaaatatc taacttgctg tctatgtttg atgcttcaca tgctagtcag 
                 60 
               
               
                   
               
               
                 aaattagaaa ttactgtcca aatgatggac acataccatt acagagaaac gcctccagat 
                 120 
               
               
                   
               
               
                 tcctcatctt ctgaaggcgg ttcattgtct agatacgacg agagaagagt ctctttgcct 
                 180 
               
               
                   
               
               
                 ctcagtcata atgctgcctc tccagatatt gtatcacaac tatgtttttc cactgcaatg 
                 240 
               
               
                   
               
               
                 tcttcagagt tgaatcacag atggaaatct caaagattaa aggtggccga ttctccttac 
                 300 
               
               
                   
               
               
                 aactatatcc taacattacc atcaaaagga attagaggtg cctttatcga ttccctgaac 
                 360 
               
               
                   
               
               
                 gtatggttgg aggttccaga ggatgaaaca tcagtcatca aggaagttat tggtatgctc 
                 420 
               
               
                   
               
               
                 cacaactctt cattaatcat tgatgacttc caagataatt ctccacttag aagaggaaag 
                 480 
               
               
                   
               
               
                 ccatctaccc atacagtctt cggccctgcc caggctatca atactgctac ttacgttata 
                 540 
               
               
                   
               
               
                 gttaaagcaa tcgaaaagat acaagacata gtgggacacg atgcattggc agatgttacg 
                 600 
               
               
                   
               
               
                 ggtactatta caactatttt ccaaggtcag gccatggact tgtggtggac agcaaatgca 
                 660 
               
               
                   
               
               
                 atcgttccat caatacagga atacttactt atggtaaacg ataaaaccgg tgctctcttt 
                 720 
               
               
                   
               
               
                 agactgagtt tggagttgtt agctctgaat tccgaagcca gtatttctga ctctgcttta 
                 780 
               
               
                   
               
               
                 gaaagtttat ctagtgctgt ttccttgcta ggtcaatact tccaaatcag agacgactat 
                 840 
               
               
                   
               
               
                 atgaacttga tcgataacaa gtatacagat cagaaaggct tctgcgaaga tcttgatgaa 
                 900 
               
               
                   
               
               
                 ggcaagtact cactaacact tattcatgcc ctccaaactg attcatccga tctactgacc 
                 960 
               
               
                   
               
               
                 aacatccttt caatgagaag agtgcaagga aagttaacgg cacaaaagag atgttggttc 
                 1020 
               
               
                   
               
               
                 tggaaatga 
                 1029 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 22 
               
               
                 
                   G. fujikuroi 
                 
               
            
           
           
               
               
            
               
                 MAEQQISNLL SMFDASHASQ KLEITVQMMD TYHYRETPPD SSSSEGGSLS RYDERRVSLP 
                 60 
               
               
                   
               
               
                 LSHNAASPDI VSQLCFSTAM SSELNHRWKS QRLKVADSPY NYILTLPSKG IRGAFIDSLN 
                 120 
               
               
                   
               
               
                 VWLEVPEDET SVIKEVIGML HNSSLIIDDF QDNSPLRRGK PSTHTVFGPA QAINTATYVI 
                 180 
               
               
                   
               
               
                 VKAIEKIQDI VGHDALADVT GTITTIFQGQ AMDLWWTANA IVPSIQEYLL MVNDKTGALF 
                 240 
               
               
                   
               
               
                 RLSLELLALN SEASISDSAL ESLSSAVSLL GQYFQIRDDY MNLIDNKYTD QKGFCEDLDE 
                 300 
               
               
                   
               
               
                 GKYSLTLIHA LQTDSSDLLT NILSMRRVQG KLTAQKRCWF WK 
                 342 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 23 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggaaaaga ctaaggagaa agcagaacgt atcttgctgg agccatacag atacttatta 
                 60 
               
               
                   
               
               
                 caactaccag gaaagcaagt ccgttctaaa ctatcacaag cgttcaatca ctggttaaaa 
                 120 
               
               
                   
               
               
                 gttcctgaag ataagttaca aatcattatt gaagtcacag aaatgctaca caatgcttct 
                 180 
               
               
                   
               
               
                 ttactgatcg atgatataga ggattcttcc aaactgagaa gaggttttcc tgtcgctcat 
                 240 
               
               
                   
               
               
                 tccatatacg gggtaccaag tgtaatcaac tcagctaatt acgtctactt cttgggattg 
                 300 
               
               
                   
               
               
                 gaaaaagtat tgacattaga tcatccagac gctgtaaagc tattcaccag acaacttctt 
                 360 
               
               
                   
               
               
                 gaattgcatc aaggtcaagg tttggatatc tattggagag acacttatac ttgcccaaca 
                 420 
               
               
                   
               
               
                 gaagaggagt acaaagcaat ggttctacaa aagactggcg gtttgttcgg acttgccgtt 
                 480 
               
               
                   
               
               
                 ggtctgatgc aacttttctc tgattacaag gaggacttaa agcctctgtt ggataccttg 
                 540 
               
               
                   
               
               
                 ggcttgtttt tccagattag agatgactac gctaacttac attcaaagga atattcagaa 
                 600 
               
               
                   
               
               
                 aacaaatcat tctgtgaaga tttgactgaa gggaagttta gttttccaac aatccacgcc 
                 660 
               
               
                   
               
               
                 atttggtcaa gaccagaatc tactcaagtg caaaacattc tgcgtcagag aacagagaat 
                 720 
               
               
                   
               
               
                 attgacatca aaaagtattg tgttcagtac ttggaagatg ttggttcttt tgcttacaca 
                 780 
               
               
                   
               
               
                 agacatacac ttagagaatt agaggcaaaa gcatacaagc aaatagaagc ctgtggaggc 
                 840 
               
               
                   
               
               
                 aatccttctc tagtggcatt ggttaaacat ttgtccaaaa tgttcaccga ggaaaacaag 
                 900 
               
               
                   
               
               
                 taa 
                 903 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 24 
               
               
                 
                   M. musculus 
                 
               
            
           
           
               
               
            
               
                 MEKTKEKAER ILLEPYRYLL QLPGKQVRSK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS 
                 60 
               
               
                   
               
               
                 LLIDDIEDSS KLRRGFPVAH SIYGVPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL 
                 120 
               
               
                   
               
               
                 ELHQGQGLDI YWRDTYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLDTL 
                 180 
               
               
                   
               
               
                 GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN 
                 240 
               
               
                   
               
               
                 IDIKKYCVQY LEDVGSFAYT RHTLRELEAK AYKQIEACGG NPSLVALVKH LSKMFTEENK 
                 300 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 25 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggcaagat tctattttct taacgcacta ttgatggtta tctcattaca atcaactaca 
                 60 
               
               
                   
               
               
                 gccttcactc cagctaaact tgcttatcca acaacaacaa cagctctaaa tgtcgcctcc 
                 120 
               
               
                   
               
               
                 gccgaaactt ctttcagtct agatgaatac ttggcctcta agataggacc tatagagtct 
                 180 
               
               
                   
               
               
                 gccttggaag catcagtcaa atccagaatt ccacagaccg ataagatctg cgaatctatg 
                 240 
               
               
                   
               
               
                 gcctactctt tgatggcagg aggcaagaga attagaccag tgttgtgtat cgctgcatgt 
                 300 
               
               
                   
               
               
                 gagatgttcg gtggatccca agatgtcgct atgcctactg ctgtggcatt agaaatgata 
                 360 
               
               
                   
               
               
                 cacacaatgt ctttgattca tgatgatttg ccatccatgg ataacgatga cttgagaaga 
                 420 
               
               
                   
               
               
                 ggtaaaccaa caaaccatgt cgttttcggc gaagatgtag ctattcttgc aggtgactct 
                 480 
               
               
                   
               
               
                 ttattgtcaa cttccttcga gcacgtcgct agagaaacaa aaggagtgtc agcagaaaag 
                 540 
               
               
                   
               
               
                 atcgtggatg ttatcgctag attaggcaaa tctgttggtg ccgagggcct tgctggcggt 
                 600 
               
               
                   
               
               
                 caagttatgg acttagaatg tgaagctaaa ccaggtacca cattagacga cttgaaatgg 
                 660 
               
               
                   
               
               
                 attcatatcc ataaaaccgc tacattgtta caagttgctg tagcttctgg tgcagttcta 
                 720 
               
               
                   
               
               
                 ggtggtgcaa ctcctgaaga ggttgctgca tgcgagttgt ttgctatgaa tataggtctt 
                 780 
               
               
                   
               
               
                 gcctttcaag ttgccgacga tatccttgat gtaaccgctt catcagaaga tttgggtaaa 
                 840 
               
               
                   
               
               
                 actgcaggca aagatgaagc tactgataag acaacttacc caaagttatt aggattagaa 
                 900 
               
               
                   
               
               
                 gagagtaagg catacgcaag acaactaatc gatgaagcca aggaaagttt ggctcctttt 
                 960 
               
               
                   
               
               
                 ggagatagag ctgccccttt attggccatt gcagatttca ttattgatag aaagaattga 
                 1020 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 26 
               
               
                 T. pseudonana 
               
            
           
           
               
               
            
               
                 MARFYFLNAL LMVISLQSTT AFTPAKLAYP TTTTALNVAS AETSFSLDEY LASKIGPIES 
                 60 
               
               
                   
               
               
                 ALEASVKSRI PQTDKICESM AYSLMAGGKR IRPVLCIAAC EMFGGSQDVA MPTAVALEMI 
                 120 
               
               
                   
               
               
                 HTMSLIHDDL PSMDNDDLRR GKPTNHVVFG EDVAILAGDS LLSTSFEHVA RETKGVSAEK 
                 180 
               
               
                   
               
               
                 IVDVIARLGK SVGAEGLAGG QVMDLECEAK PGTTLDDLKW IHIHKTATLL QVAVASGAVL 
                 240 
               
               
                   
               
               
                 GGATPEEVAA CELFAMNIGL AFQVADDILD VTASSEDLGK TAGKDEATDK TTYPKLLGLE 
                 300 
               
               
                   
               
               
                 ESKAYARQLI DEAKESLAPF GDRAAPLLAI ADFIIDRKN 
                 339 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 27 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgcacttag caccacgtag agtccctaga ggtagaagat caccacctga cagagttcct 
                 60 
               
               
                   
               
               
                 gaaagacaag gtgccttggg tagaagacgt ggagctggct ctactggctg tgcccgtgct 
                 120 
               
               
                   
               
               
                 gctgctggtg ttcaccgtag aagaggagga ggcgaggctg atccatcagc tgctgtgcat 
                 180 
               
               
                   
               
               
                 agaggctggc aagccggtgg tggcaccggt ttgcctgatg aggtggtgtc taccgcagcc 
                 240 
               
               
                   
               
               
                 gccttagaaa tgtttcatgc ttttgcttta atccatgatg atatcatgga tgatagtgca 
                 300 
               
               
                   
               
               
                 actagaagag gctccccaac tgttcacaga gccctagctg atcgtttagg cgctgctctg 
                 360 
               
               
                   
               
               
                 gacccagatc aggccggtca actaggagtt tctactgcta tcttggttgg agatctggct 
                 420 
               
               
                   
               
               
                 ttgacatggt ccgatgaatt gttatacgct ccattgactc cacatagact ggcagcagta 
                 480 
               
               
                   
               
               
                 ctaccattgg taacagctat gagagctgaa accgttcatg gccaatatct tgatataact 
                 540 
               
               
                   
               
               
                 agtgctagaa gacctgggac cgatacttct cttgcattga gaatagccag atataagaca 
                 600 
               
               
                   
               
               
                 gcagcttaca caatggaacg tccactgcac attggtgcag ccctggctgg ggcaagacca 
                 660 
               
               
                   
               
               
                 gaactattag cagggctttc agcatacgcc ttgccagctg gagaagcctt ccaattggca 
                 720 
               
               
                   
               
               
                 gatgacctgc taggcgtctt cggtgatcca agacgtacag ggaaacctga cctagatgat 
                 780 
               
               
                   
               
               
                 cttagaggtg gaaagcatac tgtcttagtc gccttggcaa gagaacatgc cactccagaa 
                 840 
               
               
                   
               
               
                 cagagacaca cattggatac attattgggt acaccaggtc ttgatagaca aggcgcttca 
                 900 
               
               
                   
               
               
                 agactaagat gcgtattggt agcaactggt gcaagagccg aagccgaaag acttattaca 
                 960 
               
               
                   
               
               
                 gagagaagag atcaagcatt aactgcattg aacgcattaa cactgccacc tcctttagct 
                 1020 
               
               
                   
               
               
                 gaggcattag caagattgac attagggtct acagctcatc ctgcctaa 
                 1068 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 28 
               
               
                 
                   S. clavuligerus 
                 
               
            
           
           
               
               
            
               
                 MHLAPRRVPR GRRSPPDRVP ERQGALGRRR GAGSTGCARA AAGVHRRRGG GEADPSAAVH 
                 60 
               
               
                   
               
               
                 RGWQAGGGTG LPDEVVSTAA ALEMFHAFAL IHDDIMDDSA TRRGSPTVHR ALADRLGAAL 
                 120 
               
               
                   
               
               
                 DPDQAGQLGV STAILVGDLA LTWSDELLYA PLTPHRLAAV LPLVTAMRAE TVHGQYLDIT 
                 180 
               
               
                   
               
               
                 SARRPGTDTS LALRIARYKT AAYTMERPLH IGAALAGARP ELLAGLSAYA LPAGEAFQLA 
                 240 
               
               
                   
               
               
                 DDLLGVFGDP RRTGKPDLDD LRGGKHTVLV ALAREHATPE QRHTLDTLLG TPGLDRQGAS 
                 300 
               
               
                   
               
               
                 RLRCVLVATG ARAEAERLIT ERRDQALTAL NALTLPPPLA EALARLTLGS TAHPA 
                 355 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 29 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgtcatatt tcgataacta cttcaatgag atagttaatt ccgtgaacga catcattaag 
                 60 
               
               
                   
               
               
                 tcttacatct ctggcgacgt accaaaacta tacgaagcct cctaccattt gtttacatca 
                 120 
               
               
                   
               
               
                 ggaggaaaga gactaagacc attgatcctt acaatttctt ctgatctttt cggtggacag 
                 180 
               
               
                   
               
               
                 agagaaagag catactatgc tggcgcagca atcgaagttt tgcacacatt cactttggtt 
                 240 
               
               
                   
               
               
                 cacgatgata tcatggatca agataacatt cgtagaggtc ttcctactgt acatgtcaag 
                 300 
               
               
                   
               
               
                 tatggcctac ctttggccat tttagctggt gacttattgc atgcaaaagc ctttcaattg 
                 360 
               
               
                   
               
               
                 ttgactcagg cattgagagg tctaccatct gaaactatca tcaaggcgtt tgatatcttt 
                 420 
               
               
                   
               
               
                 acaagatcta tcattatcat atcagaaggt caagctgtcg atatggaatt cgaagataga 
                 480 
               
               
                   
               
               
                 attgatatca aggaacaaga gtatttggat atgatatctc gtaaaaccgc tgccttattc 
                 540 
               
               
                   
               
               
                 tcagcttctt cttccattgg ggcgttgata gctggagcta atgataacga tgtgagatta 
                 600 
               
               
                   
               
               
                 atgtccgatt tcggtacaaa tcttgggatc gcatttcaaa ttgtagatga tatacttggt 
                 660 
               
               
                   
               
               
                 ttaacagctg atgaaaaaga gctaggaaaa cctgttttca gtgatatcag agaaggtaaa 
                 720 
               
               
                   
               
               
                 aagaccatat tagtcattaa gactttagaa ttgtgtaagg aagacgagaa aaagattgtg 
                 780 
               
               
                   
               
               
                 ttaaaagcgc taggcaacaa gtcagcatca aaggaagagt tgatgagttc tgctgacata 
                 840 
               
               
                   
               
               
                 atcaaaaagt actcattgga ttacgcctac aacttagctg agaaatacta caaaaacgcc 
                 900 
               
               
                   
               
               
                 atcgattctc taaatcaagt ttcaagtaaa agtgatattc cagggaaggc attgaaatat 
                 960 
               
               
                   
               
               
                 cttgctgaat tcaccatcag aagacgtaag taa 
                 993 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 30 
               
               
                 
                   S. acidocaldarius 
                 
               
            
           
           
               
               
            
               
                 MSYFDNYFNE IVNSVNDIIK SYISGDVPKL YEASYHLFTS GGKRLRPLIL TISSDLFGGQ 
                 60 
               
               
                   
               
               
                 RERAYYAGAA IEVLHTFTLV HDDIMDQDNI RRGLPTVHVK YGLPLAILAG DLLHAKAFQL 
                 120 
               
               
                   
               
               
                 LTQALRGLPS ETIIKAFDIF TRSIIIISEG QAVDMEFEDR IDIKEQEYLD MISRKTAALF 
                 180 
               
               
                   
               
               
                 SASSSIGALI AGANDNDVRL MSDFGTNLGI AFQIVDDILG LTADEKELGK PVFSDIREGK 
                 240 
               
               
                   
               
               
                 KTILVIKTLE LCKEDEKKIV LKALGNKSAS KEELMSSADI IKKYSLDYAY NLAEKYYKNA 
                 300 
               
               
                   
               
               
                 IDSLNQVSSK SDIPGKALKY LAEFTIRRRK 
                 330 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 31 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggtcgcac aaactttcaa cctggatacc tacttatccc aaagacaaca acaagttgaa 
                 60 
               
               
                   
               
               
                 gaggccctaa gtgctgctct tgtgccagct tatcctgaga gaatatacga agctatgaga 
                 120 
               
               
                   
               
               
                 tactccctcc tggcaggtgg caaaagatta agacctatct tatgtttagc tgcttgcgaa 
                 180 
               
               
                   
               
               
                 ttggcaggtg gttctgttga acaagccatg ccaactgcgt gtgcacttga aatgatccat 
                 240 
               
               
                   
               
               
                 acaatgtcac taattcatga tgacctgcca gccatggata acgatgattt cagaagagga 
                 300 
               
               
                   
               
               
                 aagccaacta atcacaaggt gttcggggaa gatatagcca tcttagcggg tgatgcgctt 
                 360 
               
               
                   
               
               
                 ttagcttacg cttttgaaca tattgcttct caaacaagag gagtaccacc tcaattggtg 
                 420 
               
               
                   
               
               
                 ctacaagtta ttgctagaat cggacacgcc gttgctgcaa caggcctcgt tggaggccaa 
                 480 
               
               
                   
               
               
                 gtcgtagacc ttgaatctga aggtaaagct atttccttag aaacattgga gtatattcac 
                 540 
               
               
                   
               
               
                 tcacataaga ctggagcctt gctggaagca tcagttgtct caggcggtat tctcgcaggg 
                 600 
               
               
                   
               
               
                 gcagatgaag agcttttggc cagattgtct cattacgcta gagatatagg cttggctttt 
                 660 
               
               
                   
               
               
                 caaatcgtcg atgatatcct ggatgttact gctacatctg aacagttggg gaaaaccgct 
                 720 
               
               
                   
               
               
                 ggtaaagacc aggcagccgc aaaggcaact tatccaagtc tattgggttt agaagcctct 
                 780 
               
               
                   
               
               
                 agacagaaag cggaagagtt gattcaatct gctaaggaag ccttaagacc ttacggttca 
                 840 
               
               
                   
               
               
                 caagcagagc cactcctagc gctggcagac ttcatcacac gtcgtcagca ttaa 
                 894 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 32 
               
               
                   Synechococcus  sp. 
               
            
           
           
               
               
            
               
                 MVAQTFNLDT YLSQRQQQVE EALSAALVPA YPERIYEAMR YSLLAGGKRL RPILCLAACE 
                 60 
               
               
                   
               
               
                 LAGGSVEQAM PTACALEMIH TMSLIHDDLP AMDNDDFRRG KPTNHKVFGE DIAILAGDAL 
                 120 
               
               
                   
               
               
                 LAYAFEHIAS QTRGVPPQLV LQVIARIGHA VAATGLVGGQ VVDLESEGKA ISLETLEYIH 
                 180 
               
               
                   
               
               
                 SHKTGALLEA SVVSGGILAG ADEELLARLS HYARDIGLAF QIVDDILDVT ATSEQLGKTA 
                 240 
               
               
                   
               
               
                 GKDQAAAKAT YPSLLGLEAS RQKAEELIQS AKEALRPYGS QAEPLLALAD FITRRQH 
                 297 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 33 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgaaaaccg ggtttatctc accagcaaca gtatttcatc acagaatctc accagcgacc 
                 60 
               
               
                   
               
               
                 actttcagac atcacttatc acctgctact acaaactcta caggcattgt cgccttaaga 
                 120 
               
               
                   
               
               
                 gacatcaact tcagatgtaa agcagtttct aaagagtact ctgatctgtt gcagaaagat 
                 180 
               
               
                   
               
               
                 gaggcttctt tcacaaaatg ggacgatgac aaggtgaaag atcatcttga taccaacaaa 
                 240 
               
               
                   
               
               
                 aacttatacc caaatgatga gattaaggaa tttgttgaat cagtaaaggc tatgttcggt 
                 300 
               
               
                   
               
               
                 agtatgaatg acggggagat aaacgtctct gcatacgata ctgcatgggt tgctttggtt 
                 360 
               
               
                   
               
               
                 caagatgtcg atggatcagg tagtcctcag ttcccttctt ctttagaatg gattgccaac 
                 420 
               
               
                   
               
               
                 aatcaattgt cagatggatc atggggagat catttgctgt tctcagctca cgatagaatc 
                 480 
               
               
                   
               
               
                 atcaacacat tagcatgcgt tattgcactt acaagttgga atgttcatcc ttctaagtgt 
                 540 
               
               
                   
               
               
                 gaaaaaggtt tgaattttct gagagaaaac atttgcaaat tagaagatga aaacgcagaa 
                 600 
               
               
                   
               
               
                 catatgccaa ttggttttga agtaacattc ccatcactaa ttgatatcgc gaaaaagttg 
                 660 
               
               
                   
               
               
                 aacattgaag tacctgagga tactccagca cttaaagaga tctacgcacg tagagatatc 
                 720 
               
               
                   
               
               
                 aagttaacta agatcccaat ggaagttctt cacaaggtac ctactacttt gttacattct 
                 780 
               
               
                   
               
               
                 ttggaaggaa tgcctgattt ggagtgggaa aaactgttaa agctacaatg taaagatggt 
                 840 
               
               
                   
               
               
                 agtttcttgt tttccccatc tagtaccgca ttcgccctaa tgcaaacaaa agatgagaaa 
                 900 
               
               
                   
               
               
                 tgcttacagt atctaacaaa tatcgtcact aagttcaacg gtggcgtgcc taatgtgtac 
                 960 
               
               
                   
               
               
                 ccagtcgatt tgtttgaaca tatttgggtt gttgatagac tgcagagatt ggggattgcc 
                 1020 
               
               
                   
               
               
                 agatacttca aatcagagat aaaagattgt gtagagtata tcaataagta ctggaccaaa 
                 1080 
               
               
                   
               
               
                 aatggaattt gttgggctag aaatactcac gttcaagata tcgatgatac agccatggga 
                 1140 
               
               
                   
               
               
                 ttcagagtgt tgagagcgca cggttatgac gtcactccag atgtttttag acaatttgaa 
                 1200 
               
               
                   
               
               
                 aaagatggta aattcgtttg ctttgcaggg caatcaacac aagccgtgac aggaatgttt 
                 1260 
               
               
                   
               
               
                 aacgtttaca gagcctctca aatgttgttc ccaggggaga gaattttgga agatgccaaa 
                 1320 
               
               
                   
               
               
                 aagttctctt acaattactt aaaggaaaag caaagtacca acgaattgct ggataaatgg 
                 1380 
               
               
                   
               
               
                 ataatcgcta aagatctacc tggtgaagtt ggttatgctc tggatatccc atggtatgct 
                 1440 
               
               
                   
               
               
                 tccttaccaa gattggaaac tcgttattac cttgaacaat acggcggtga agatgatgtc 
                 1500 
               
               
                   
               
               
                 tggataggca agacattata cagaatgggt tacgtgtcca ataacacata tctagaaatg 
                 1560 
               
               
                   
               
               
                 gcaaagctgg attacaataa ctatgttgca gtccttcaat tagaatggta cacaatacaa 
                 1620 
               
               
                   
               
               
                 caatggtacg tcgatattgg tatagagaag ttcgaatctg acaacatcaa gtcagtcctg 
                 1680 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 34 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MKTGFISPAT VFHHRISPAT TFRHHLSPAT TNSTGIVALR DINFRCKAVS KEYSDLLQKD 
                 60 
               
               
                   
               
               
                 EASFTKWDDD KVKDHLDTNK NLYPNDEIKE FVESVKAMFG SMNDGEINVS AYDTAWVALV 
                 120 
               
               
                   
               
               
                 QDVDGSGSPQ FPSSLEWIAN NQLSDGSWGD HLLFSAHDRI INTLACVIAL TSWNVHPSKC 
                 180 
               
               
                   
               
               
                 EKGLNFLREN ICKLEDENAE HMPIGFEVTF PSLIDIAKKL NIEVPEDTPA LKEIYARRDI 
                 240 
               
               
                   
               
               
                 KLTKIPMEVL HKVPTTLLHS LEGMPDLEWE KLLKLQCKDG SFLFSPSSTA FALMQTKDEK 
                 300 
               
               
                   
               
               
                 CLQYLTNIVT KFNGGVPNVY PVDLFEHIWV VDRLQRLGIA RYFKSEIKDC VEYINKYWTK 
                 360 
               
               
                   
               
               
                 NGICWARNTH VQDIDDTAMG FRVLRAHGYD VTPDVFRQFE KDGKFVCFAG QSTQAVTGMF 
                 420 
               
               
                   
               
               
                 NVYRASQMLF PGERILEDAK KFSYNYLKEK QSTNELLDKW IIAKDLPGEV GYALDIPWYA 
                 480 
               
               
                   
               
               
                 SLPRLETRYY LEQYGGEDDV WIGKTLYRMG YVSNNTYLEM AKLDYNNYVA VLQLEWYTIQ 
                 540 
               
               
                   
               
               
                 QWYVDIGIEK FESDNIKSVL VSYYLAAASI FEPERSKERI AWAKTTILVD KITSIFDSSQ 
                 600 
               
               
                   
               
               
                 SSKEDITAFI DKFRNKSSSK KHSINGEPWH EVMVALKKTL HGFALDALMT HSQDIHPQLH 
                 660 
               
               
                   
               
               
                 QAWEMWLTKL QDGVDVTAEL MVQMINMTAG RWVSKELLTH PQYQRLSTVT NSVCHDITKL 
                 720 
               
               
                   
               
               
                 HNFKENSTTV DSKVQELVQL VFSDTPDDLD QDMKQTFLTV MKTFYYKAWC DPNTINDHIS 
                 780 
               
               
                   
               
               
                 KVFEIVI 
                 787 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 35 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgcctgatg cacacgatgc tccacctcca caaataagac agagaacact agtagatgag 
                 60 
               
               
                   
               
               
                 gctacccaac tgctaactga gtccgcagaa gatgcatggg gtgaagtcag tgtgtcagaa 
                 120 
               
               
                   
               
               
                 tacgaaacag caaggctagt tgcccatgct acatggttag gtggacacgc cacaagagtg 
                 180 
               
               
                   
               
               
                 gccttccttc tggagagaca acacgaagac gggtcatggg gtccaccagg tggatatagg 
                 240 
               
               
                   
               
               
                 ttagtcccta cattatctgc tgttcacgca ttattgacat gtcttgcctc tcctgctcag 
                 300 
               
               
                   
               
               
                 gatcatggcg ttccacatga tagactttta agagctgttg acgcaggctt gactgccttg 
                 360 
               
               
                   
               
               
                 agaagattgg ggacatctga ctccccacct gatactatag cagttgagct ggttatccca 
                 420 
               
               
                   
               
               
                 tctttgctag agggcattca acacttactg gaccctgctc atcctcatag tagaccagcc 
                 480 
               
               
                   
               
               
                 ttctctcaac atagaggctc tcttgtttgt cctggtggac tagatgggag aactctagga 
                 540 
               
               
                   
               
               
                 gctttgagat cacacgccgc agcaggtaca ccagtaccag gaaaagtctg gcacgcttcc 
                 600 
               
               
                   
               
               
                 gagactttgg gcttgagtac cgaagctgct tctcacttgc aaccagccca aggtataatc 
                 660 
               
               
                   
               
               
                 ggtggctctg ctgctgccac agcaacatgg ctaaccaggg ttgcaccatc tcaacagtca 
                 720 
               
               
                   
               
               
                 gattctgcca gaagatacct tgaggaatta caacacagat actctggccc agttccttcc 
                 780 
               
               
                   
               
               
                 attaccccta tcacatactt cgaaagagca tggttattga acaattttgc agcagccggt 
                 840 
               
               
                   
               
               
                 gttccttgtg aggctccagc tgctttgttg gattccttag aagcagcact tacaccacaa 
                 900 
               
               
                   
               
               
                 ggtgctcctg ctggagcagg attgcctcca gatgctgatg atacagccgc tgtgttgctt 
                 960 
               
               
                   
               
               
                 gcattggcaa cacatgggag aggtagaaga ccagaagtac tgatggatta caggactgac 
                 1020 
               
               
                   
               
               
                 gggtatttcc aatgctttat tggggaaagg actccatcaa tttcaacaaa cgctcacgta 
                 1080 
               
               
                   
               
               
                 ttggaaacat tagggcatca tgtggcccaa catccacaag atagagccag atacggatca 
                 1140 
               
               
                   
               
               
                 gccatggata ccgcatcagc ttggctgctg gcagctcaaa agcaagatgg ctcttggtta 
                 1200 
               
               
                   
               
               
                 gataaatggc atgcctcacc atactacgct actgtttgtt gcacacaagc cctagccgct 
                 1260 
               
               
                   
               
               
                 catgcaagtc ctgcaactgc accagctaga cagagagctg tcagatgggt tttagccaca 
                 1320 
               
               
                   
               
               
                 caaagatccg atggcggttg gggtctatgg cattcaactg ttgaagagac tgcttatgcc 
                 1380 
               
               
                   
               
               
                 ttacagatct tggccccacc ttctggtggt ggcaatatcc cagtccaaca agcacttact 
                 1440 
               
               
                   
               
               
                 agaggcagag caagattgtg tggagccttg ccactgactc ctttatggca tgataaggat 
                 1500 
               
               
                   
               
               
                 ttgtatactc cagtaagagt agtcagagct gccagagctg ctgctctgta cactaccaga 
                 1560 
               
               
                   
               
               
                 gatctattgt taccaccatt gtaa 
                 1584 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 36 
               
               
                 
                   S. clavuligerus 
                 
               
            
           
           
               
               
            
               
                 MPDAHDAPPP QIRQRTLVDE ATQLLTESAE DAWGEVSVSE YETARLVAHA TWLGGHATRV 
                 60 
               
               
                   
               
               
                 AFLLERQHED GSWGPPGGYR LVPTLSAVHA LLTCLASPAQ DHGVPHDRLL RAVDAGLTAL 
                 120 
               
               
                   
               
               
                 RRLGTSDSPP DTIAVELVIP SLLEGIQHLL DPAHPHSRPA FSQHRGSLVC PGGLDGRTLG 
                 180 
               
               
                   
               
               
                 ALRSHAAAGT PVPGKVWHAS ETLGLSTEAA SHLQPAQGII GGSAAATATW LTRVAPSQQS 
                 240 
               
               
                   
               
               
                 DSARRYLEEL QHRYSGPVPS ITPITYFERA WLLNNFAAAG VPCEAPAALL DSLEAALTPQ 
                 300 
               
               
                   
               
               
                 GAPAGAGLPP DADDTAAVLL ALATHGRGRR PEVLMDYRTD GYFQCFIGER TPSISTNAHV 
                 360 
               
               
                   
               
               
                 LETLGHHVAQ HPQDRARYGS AMDTASAWLL AAQKQDGSWL DKWHASPYYA TVCCTQALAA 
                 420 
               
               
                   
               
               
                 HASPATAPAR QRAVRWVLAT QRSDGGWGLW HSTVEETAYA LQILAPPSGG GNIPVQQALT 
                 480 
               
               
                   
               
               
                 RGRARLCGAL PLTPLWHDKD LYTPVRVVRA ARAAALYTTR DLLLPPL 
                 527 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 37 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgaacgccc tatccgaaca cattttgtct gaattgagaa gattattgtc tgaaatgagt 
                 60 
               
               
                   
               
               
                 gatggcggat ctgttggtcc atctgtgtat gatacggccc aggccctaag attccacggt 
                 120 
               
               
                   
               
               
                 aacgtaacag gtagacaaga tgcatatgct tggttgatcg cccagcaaca agcagatgga 
                 180 
               
               
                   
               
               
                 ggttggggct ctgccgactt tccactcttt agacatgctc caacatgggc tgcacttctc 
                 240 
               
               
                   
               
               
                 gcattacaaa gagctgatcc acttcctggc gcagcagacg cagttcagac cgcaacaaga 
                 300 
               
               
                   
               
               
                 ttcttgcaaa gacaaccaga tccatacgct catgccgttc ctgaggatgc ccctattggt 
                 360 
               
               
                   
               
               
                 gctgaactga tcttgcctca gttttgtgga gaggctgctt ggttgttggg aggtgtggcc 
                 420 
               
               
                   
               
               
                 ttccctagac acccagccct attaccatta agacaggctt gtttagtcaa actgggtgca 
                 480 
               
               
                   
               
               
                 gtcgccatgt tgccttcagg acacccattg ctccactcct gggaggcatg gggtacttct 
                 540 
               
               
                   
               
               
                 ccaacaacag cctgtccaga cgatgatggt tctataggta tctcaccagc agctacagcc 
                 600 
               
               
                   
               
               
                 gcctggagag cccaggctgt gaccagaggc tcaactcctc aagtgggcag agctgacgca 
                 660 
               
               
                   
               
               
                 tacttacaaa tggcttcaag agcaacgaga tcaggcatag aaggagtctt ccctaatgtt 
                 720 
               
               
                   
               
               
                 tggcctataa acgtattcga accatgctgg tcactgtaca ctctccatct tgccggtctg 
                 780 
               
               
                   
               
               
                 ttcgcccatc cagcactggc tgaggctgta agagttatcg ttgctcaact tgaagcaaga 
                 840 
               
               
                   
               
               
                 ttgggagtgc atggcctcgg accagcttta cattttgctg ccgacgctga tgatactgca 
                 900 
               
               
                   
               
               
                 gttgccttat gcgttctgca tttggctggc agagatcctg cagttgacgc attgagacat 
                 960 
               
               
                   
               
               
                 tttgaaattg gtgagctctt tgttacattc ccaggagaga gaaatgctag tgtctctacg 
                 1020 
               
               
                   
               
               
                 aacattcacg ctcttcatgc tttgagattg ttaggtaaac cagctgccgg agcaagtgca 
                 1080 
               
               
                   
               
               
                 tacgtcgaag caaatagaaa tccacatggt ttgtgggaca acgaaaaatg gcacgtttca 
                 1140 
               
               
                   
               
               
                 tggctttatc caactgcaca cgccgttgca gctctagctc aaggcaagcc tcaatggaga 
                 1200 
               
               
                   
               
               
                 gatgaaagag cactagccgc tctactacaa gctcaaagag atgatggtgg ttggggagct 
                 1260 
               
               
                   
               
               
                 ggtagaggat ccactttcga ggaaaccgcc tacgctcttt tcgctttaca cgttatggac 
                 1320 
               
               
                   
               
               
                 ggatctgagg aagccacagg cagaagaaga atcgctcaag tcgtcgcaag agccttagaa 
                 1380 
               
               
                   
               
               
                 tggatgctag ctagacatgc cgcacatgga ttaccacaaa caccactctg gattggtaag 
                 1440 
               
               
                   
               
               
                 gaattgtact gtcctactag agtcgtaaga gtagctgagc tagctggcct gtggttagca 
                 1500 
               
               
                   
               
               
                 ttaagatggg gtagaagagt attagctgaa ggtgctggtg ctgcacctta a 
                 1551 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 38 
               
               
                 
                   B. japonicum 
                 
               
            
           
           
               
               
            
               
                 MNALSEHILS ELRRLLSEMS DGGSVGPSVY DTAQALRFHG NVTGRQDAYA WLIAQQQADG 
                 60 
               
               
                   
               
               
                 GWGSADFPLF RHAPTWAALL ALQRADPLPG AADAVQTATR FLQRQPDPYA HAVPEDAPIG 
                 120 
               
               
                   
               
               
                 AELILPQFCG EAAWLLGGVA FPRHPALLPL RQACLVKLGA VAMLPSGHPL LHSWEAWGTS 
                 180 
               
               
                   
               
               
                 PTTACPDDDG SIGISPAATA AWRAQAVTRG STPQVGRADA YLQMASRATR SGIEGVFPNV 
                 240 
               
               
                   
               
               
                 WPINVFEPCW SLYTLHLAGL FAHPALAEAV RVIVAQLEAR LGVHGLGPAL HFAADADDTA 
                 300 
               
               
                   
               
               
                 VALCVLHLAG RDPAVDALRH FEIGELFVTF PGERNASVST NIHALHALRL LGKPAAGASA 
                 360 
               
               
                   
               
               
                 YVEANRNPHG LWDNEKWHVS WLYPTAHAVA ALAQGKPQWR DERALAALLQ AQRDDGGWGA 
                 420 
               
               
                   
               
               
                 GRGSTFEETA YALFALHVMD GSEEATGRRR IAQVVARALE WMLARHAAHG LPQTPLWIGK 
                 480 
               
               
                   
               
               
                 ELYCPTRVVR VAELAGLWLA LRWGRRVLAE GAGAAP 
                 516 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 39 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggttttgt cttcttcttg tactacagta ccacacttat cttcattagc tgtcgtgcaa 
                 60 
               
               
                   
               
               
                 cttggtcctt ggagcagtag gattaaaaag aaaaccgata ctgttgcagt accagccgct 
                 120 
               
               
                   
               
               
                 gcaggaaggt ggagaagggc cttggctaga gcacagcaca catcagaatc cgcagctgtc 
                 180 
               
               
                   
               
               
                 gcaaagggca gcagtttgac ccctatagtg agaactgacg ctgagtcaag gagaacaaga 
                 240 
               
               
                   
               
               
                 tggccaaccg atgacgatga cgccgaacct ttagtggatg agatcagggc aatgcttact 
                 300 
               
               
                   
               
               
                 tccatgtctg atggtgacat ttccgtgagc gcatacgata cagcctgggt cggattggtt 
                 360 
               
               
                   
               
               
                 ccaagattag acggcggtga aggtcctcaa tttccagcag ctgtgagatg gataagaaat 
                 420 
               
               
                   
               
               
                 aaccagttgc ctgacggaag ttggggcgat gccgcattat tctctgccta tgacaggctt 
                 480 
               
               
                   
               
               
                 atcaataccc ttgcctgcgt tgtaactttg acaaggtggt ccctagaacc agagatgaga 
                 540 
               
               
                   
               
               
                 ggtagaggac tatctttttt gggtaggaac atgtggaaat tagcaactga agatgaagag 
                 600 
               
               
                   
               
               
                 tcaatgccta ttggcttcga attagcattt ccatctttga tagagcttgc taagagccta 
                 660 
               
               
                   
               
               
                 ggtgtccatg acttccctta tgatcaccag gccctacaag gaatctactc ttcaagagag 
                 720 
               
               
                   
               
               
                 atcaaaatga agaggattcc aaaagaagtg atgcataccg ttccaacatc aatattgcac 
                 780 
               
               
                   
               
               
                 agtttggagg gtatgcctgg cctagattgg gctaaactac ttaaactaca gagcagcgac 
                 840 
               
               
                   
               
               
                 ggaagttttt tgttctcacc agctgccact gcatatgctt taatgaatac cggagatgac 
                 900 
               
               
                   
               
               
                 aggtgtttta gctacatcga tagaacagta aagaaattca acggcggcgt ccctaatgtt 
                 960 
               
               
                   
               
               
                 tatccagtgg atctatttga acatatttgg gccgttgata gacttgaaag attaggaatc 
                 1020 
               
               
                   
               
               
                 tccaggtact tccaaaagga gatcgaacaa tgcatggatt atgtaaacag gcattggact 
                 1080 
               
               
                   
               
               
                 gaggacggta tttgttgggc aaggaactct gatgtcaaag aggtggacga cacagctatg 
                 1140 
               
               
                   
               
               
                 gcctttagac ttcttaggtt gcacggctac agcgtcagtc ctgatgtgtt taaaaacttc 
                 1200 
               
               
                   
               
               
                 gaaaaggacg gtgaattttt cgcatttgtc ggacagtcta atcaagctgt taccggtatg 
                 1260 
               
               
                   
               
               
                 tacaacttaa acagagcaag ccagatatcc ttcccaggcg aggatgtgct tcatagagct 
                 1320 
               
               
                   
               
               
                 ggtgccttct catatgagtt cttgaggaga aaagaagcag agggagcttt gagggacaag 
                 1380 
               
               
                   
               
               
                 tggatcattt ctaaagatct acctggtgaa gttgtgtata ctttggattt tccatggtac 
                 1440 
               
               
                   
               
               
                 ggcaacttac ctagagtcga ggccagagac tacctagagc aatacggagg tggtgatgac 
                 1500 
               
               
                   
               
               
                 gtttggattg gcaagacatt gtataggatg ccacttgtaa acaatgatgt atatttggaa 
                 1560 
               
               
                   
               
               
                 ttggcaagaa tggatttcaa ccactgccag gctttgcatc agttagagtg gcaaggacta 
                 1620 
               
               
                   
               
               
                 aaaagatggt atactgaaaa taggttgatg gactttggtg tcgcccaaga agatgccctt 
                 1680 
               
               
                   
               
               
                 agagcttatt ttcttgcagc cgcatctgtt tacgagcctt gtagagctgc cgagaggctt 
                 1740 
               
               
                   
               
               
                 gcatgggcta gagccgcaat actagctaac gccgtgagca cccacttaag aaatagccca 
                 1800 
               
               
                   
               
               
                 tcattcagag aaaggttaga gcattctctt aggtgtagac ctagtgaaga gacagatggc 
                 1860 
               
               
                   
               
               
                 tcctggttta actcctcaag tggctctgat gcagttttag taaaggctgt cttaagactt 
                 1920 
               
               
                   
               
               
                 actgattcat tagccaggga agcacagcca atccatggag gtgacccaga agatattata 
                 1980 
               
               
                   
               
               
                 cacaagttgt taagatctgc ttgggccgag tgggttaggg aaaaggcaga cgctgccgat 
                 2040 
               
               
                   
               
               
                 agcgtgtgca atggtagttc tgcagtagaa caagagggat caagaatggt ccatgataaa 
                 2100 
               
               
                   
               
               
                 cagacctgtc tattattggc tagaatgatc gaaatttctg ccggtagggc agctggtgaa 
                 2160 
               
               
                   
               
               
                 gcagccagtg aggacggcga tagaagaata attcaattaa caggctccat ctgcgacagt 
                 2220 
               
               
                   
               
               
                 cttaagcaaa aaatgctagt ttcacaggac cctgaaaaaa atgaagagat gatgtctcac 
                 2280 
               
               
                   
               
               
                 gtggatgacg aattgaagtt gaggattaga gagttcgttc aatatttgct tagactaggt 
                 2340 
               
               
                   
               
               
                 gaaaaaaaga ctggatctag cgaaaccagg caaacatttt taagtatagt gaaatcatgt 
                 2400 
               
               
                   
               
               
                 tactatgctg ctcattgccc acctcatgtc gttgatagac acattagtag agtgattttc 
                 2460 
               
               
                   
               
               
                 gagccagtaa gtgccgcaaa gtaaccgcgg 
                 2490 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 40 
               
               
                 
                   Z. mays 
                 
               
            
           
           
               
               
            
               
                 MVLSSSCTTV PHLSSLAVVQ LGPWSSRIKK KTDTVAVPAA AGRWRRALAR AQHTSESAAV 
                 60 
               
               
                   
               
               
                 AKGSSLTPIV RTDAESRRTR WPTDDDDAEP LVDEIRAMLT SMSDGDISVS AYDTAWVGLV 
                 120 
               
               
                   
               
               
                 PRLDGGEGPQ FPAAVRWIRN NQLPDGSWGD AALFSAYDRL INTLACVVTL TRWSLEPEMR 
                 180 
               
               
                   
               
               
                 GRGLSFLGRN MWKLATEDEE SMPIGFELAF PSLIELAKSL GVHDFPYDHQ ALQGIYSSRE 
                 240 
               
               
                   
               
               
                 IKMKRIPKEV MHTVPTSILH SLEGMPGLDW AKLLKLQSSD GSFLFSPAAT AYALMNTGDD 
                 300 
               
               
                   
               
               
                 RCFSYIDRTV KKFNGGVPNV YPVDLFEHIW AVDRLERLGI SRYFQKEIEQ CMDYVNRHWT 
                 360 
               
               
                   
               
               
                 EDGICWARNS DVKEVDDTAM AFRLLRLHGY SVSPDVFKNF EKDGEFFAFV GQSNQAVTGM 
                 420 
               
               
                   
               
               
                 YNLNRASQIS FPGEDVLHRA GAFSYEFLRR KEAEGALRDK WIISKDLPGE VVYTLDFPWY 
                 480 
               
               
                   
               
               
                 GNLPRVEARD YLEQYGGGDD VWIGKTLYRM PLVNNDVYLE LARMDFNHCQ ALHQLEWQGL 
                 540 
               
               
                   
               
               
                 KRWYTENRLM DFGVAQEDAL RAYFLAAASV YEPCRAAERL AWARAAILAN AVSTHLRNSP 
                 600 
               
               
                   
               
               
                 SFRERLEHSL RCRPSEETDG SWFNSSSGSD AVLVKAVLRL TDSLAREAQP IHGGDPEDII 
                 660 
               
               
                   
               
               
                 HKLLRSAWAE WVREKADAAD SVCNGSSAVE QEGSRMVHDK QTCLLLARMI EISAGRAAGE 
                 720 
               
               
                   
               
               
                 AASEDGDRRI IQLTGSICDS LKQKMLVSQD PEKNEEMMSH VDDELKLRIR EFVQYLLRLG 
                 780 
               
               
                   
               
               
                 EKKTGSSETR QTFLSIVKSC YYAAHCPPHV VDRHISRVIF EPVSAAK 
                 827 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 41 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 cttcttcact aaatacttag acagagaaaa cagagctttt taaagccatg tctcttcagt 
                 60 
               
               
                   
               
               
                 atcatgttct aaactccatt ccaagtacaa cctttctcag ttctactaaa acaacaatat 
                 120 
               
               
                   
               
               
                 cttcttcttt ccttaccatc tcaggatctc ctctcaatgt cgctagagac aaatccagaa 
                 180 
               
               
                   
               
               
                 gcggttccat acattgttca aagcttcgaa ctcaagaata cattaattct caagaggttc 
                 240 
               
               
                   
               
               
                 aacatgattt gcctctaata catgagtggc aacagcttca aggagaagat gctcctcaga 
                 300 
               
               
                   
               
               
                 ttagtgttgg aagtaatagt aatgcattca aagaagcagt gaagagtgtg aaaacgatct 
                 360 
               
               
                   
               
               
                 tgagaaacct aacggacggg gaaattacga tatcggctta cgatacagct tgggttgcat 
                 420 
               
               
                   
               
               
                 tgatcgatgc cggagataaa actccggcgt ttccctccgc cgtgaaatgg atcgccgaga 
                 480 
               
               
                   
               
               
                 accaactttc cgatggttct tggggagatg cgtatctctt ctcttatcat gatcgtctca 
                 540 
               
               
                   
               
               
                 tcaataccct tgcatgcgtc gttgctctaa gatcatggaa tctctttcct catcaatgca 
                 600 
               
               
                   
               
               
                 acaaaggaat cacgtttttc cgggaaaata ttgggaagct agaagacgaa aatgatgagc 
                 660 
               
               
                   
               
               
                 atatgccaat cggattcgaa gtagcattcc catcgttgct tgagatagct cgaggaataa 
                 720 
               
               
                   
               
               
                 acattgatgt accgtacgat tctccggtct taaaagatat atacgccaag aaagagctaa 
                 780 
               
               
                   
               
               
                 agcttacaag gataccaaaa gagataatgc acaagatacc aacaacattg ttgcatagtt 
                 840 
               
               
                   
               
               
                 tggaggggat gcgtgattta gattgggaaa agctcttgaa acttcaatct caagacggat 
                 900 
               
               
                   
               
               
                 ctttcctctt ctctccttcc tctaccgctt ttgcattcat gcagacccga gacagtaact 
                 960 
               
               
                   
               
               
                 gcctcgagta tttgcgaaat gccgtcaaac gtttcaatgg aggagttccc aatgtctttc 
                 1020 
               
               
                   
               
               
                 ccgtggatct tttcgagcac atatggatag tggatcggtt acaacgttta gggatatcga 
                 1080 
               
               
                   
               
               
                 gatactttga agaagagatt aaagagtgtc ttgactatgt ccacagatat tggaccgaca 
                 1140 
               
               
                   
               
               
                 atggcatatg ttgggctaga tgttcccatg tccaagacat cgatgataca gccatggcat 
                 1200 
               
               
                   
               
               
                 ttaggctctt aagacaacat ggataccaag tgtccgcaga tgtattcaag aactttgaga 
                 1260 
               
               
                   
               
               
                 aagagggaga gtttttctgc tttgtggggc aatcaaacca agcagtaacc ggtatgttca 
                 1320 
               
               
                   
               
               
                 acctataccg ggcatcacaa ttggcgtttc caagggaaga gatattgaaa aacgccaaag 
                 1380 
               
               
                   
               
               
                 agttttctta taattatctg ctagaaaaac gggagagaga ggagttgatt gataagtgga 
                 1440 
               
               
                   
               
               
                 ttataatgaa agacttacct ggcgagattg ggtttgcgtt agagattcca tggtacgcaa 
                 1500 
               
               
                   
               
               
                 gcttgcctcg agtagagacg agattctata ttgatcaata tggtggagaa aacgacgttt 
                 1560 
               
               
                   
               
               
                 ggattggcaa gactctttat aggatgccat acgtgaacaa taatggatat ctggaattag 
                 1620 
               
               
                   
               
               
                 caaaacaaga ttacaacaat tgccaagctc agcatcagct cgaatgggac atattccaaa 
                 1680 
               
               
                   
               
               
                 agtggtatga agaaaatagg ttaagtgagt ggggtgtgcg cagaagtgag cttctcgagt 
                 1740 
               
               
                   
               
               
                 gttactactt agcggctgca actatatttg aatcagaaag gtcacatgag agaatggttt 
                 1800 
               
               
                   
               
               
                 gggctaagtc aagtgtattg gttaaagcca tttcttcttc ttttggggaa tcctctgact 
                 1860 
               
               
                   
               
               
                 ccagaagaag cttctccgat cagtttcatg aatacattgc caatgctcga cgaagtgatc 
                 1920 
               
               
                   
               
               
                 atcactttaa tgacaggaac atgagattgg accgaccagg atcggttcag gccagtcggc 
                 1980 
               
               
                   
               
               
                 ttgccggagt gttaatcggg actttgaatc aaatgtcttt tgaccttttc atgtctcatg 
                 2040 
               
               
                   
               
               
                 gccgtgacgt taacaatctc ctctatctat cgtggggaga ttggatggaa aaatggaaac 
                 2100 
               
               
                   
               
               
                 tatatggaga tgaaggagaa ggagagctca tggtgaagat gataattcta atgaagaaca 
                 2160 
               
               
                   
               
               
                 atgacctaac taacttcttc acccacactc acttcgttcg tctcgcggaa atcatcaatc 
                 2220 
               
               
                   
               
               
                 gaatctgtct tcctcgccaa tacttaaagg caaggagaaa cgatgagaag gagaagacaa 
                 2280 
               
               
                   
               
               
                 taaagagtat ggagaaggag atggggaaaa tggttgagtt agcattgtcg gagagtgaca 
                 2340 
               
               
                   
               
               
                 catttcgtga cgtcagcatc acgtttcttg atgtagcaaa agcattttac tactttgctt 
                 2400 
               
               
                   
               
               
                 tatgtggcga tcatctccaa actcacatct ccaaagtctt gtttcaaaaa gtctagtaac 
                 2460 
               
               
                   
               
               
                 ctcatcatca tcatcgatcc attaacaatc agtggatcga tgtatccata gatgcgtgaa 
                 2520 
               
               
                   
               
               
                 taatatttca tgtagagaag gagaacaaat tagatcatgt agggttatca 
                 2570 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 42 
               
               
                 
                   A. thaliana 
                 
               
            
           
           
               
               
            
               
                 MSLQYHVLNS IPSTTFLSST KTTISSSFLT ISGSPLNVAR DKSRSGSIHC SKLRTQEYIN 
                 60 
               
               
                   
               
               
                 SQEVQHDLPL IHEWQQLQGE DAPQISVGSN SNAFKEAVKS VKTILRNLTD GEITISAYDT 
                 120 
               
               
                   
               
               
                 AWVALIDAGD KTPAFPSAVK WIAENQLSDG SWGDAYLFSY HDRLINTLAC VVALRSWNLF 
                 180 
               
               
                   
               
               
                 PHQCNKGITF FRENIGKLED ENDEHMPIGF EVAFPSLLEI ARGINIDVPY DSPVLKDIYA 
                 240 
               
               
                   
               
               
                 KKELKLTRIP KEIMHKIPTT LLHSLEGMRD LDWEKLLKLQ SQDGSFLFSP SSTAFAFMQT 
                 300 
               
               
                   
               
               
                 RDSNCLEYLR NAVKRFNGGV PNVFPVDLFE HIWIVDRLQR LGISRYFEEE IKECLDYVHR 
                 360 
               
               
                   
               
               
                 YWTDNGICWA RCSHVQDIDD TAMAFRLLRQ HGYQVSADVF KNFEKEGEFF CFVGQSNQAV 
                 420 
               
               
                   
               
               
                 TGMFNLYRAS QLAFPREEIL KNAKEFSYNY LLEKREREEL IDKWIIMKDL PGEIGFALEI 
                 480 
               
               
                   
               
               
                 PWYASLPRVE TRFYIDQYGG ENDVWIGKTL YRMPYVNNNG YLELAKQDYN NCQAQHQLEW 
                 540 
               
               
                   
               
               
                 DIFQKWYEEN RLSEWGVRRS ELLECYYLAA ATIFESERSH ERMVWAKSSV LVKAISSSFG 
                 600 
               
               
                   
               
               
                 ESSDSRRSFS DQFHEYIANA RRSDHHFNDR NMRLDRPGSV QASRLAGVLI GTLNQMSFDL 
                 660 
               
               
                   
               
               
                 FMSHGRDVNN LLYLSWGDWM EKWKLYGDEG EGELMVKMII LMKNNDLTNF FTHTHFVRLA 
                 720 
               
               
                   
               
               
                 EIINRICLPR QYLKARRNDE KEKTIKSMEK EMGKMVELAL SESDTFRDVS ITFLDVAKAF 
                 780 
               
               
                   
               
               
                 YYFALCGDHL QTHISKVLFQ KV 
                 802 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 43 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgaatttga gtttgtgtat agcatctcca ctattgacca aatctaatag accagctgct 
                 60 
               
               
                   
               
               
                 ttatcagcaa ttcatacagc tagtacatcc catggtggcc aaaccaaccc tacgaatctg 
                 120 
               
               
                   
               
               
                 ataatcgata cgaccaagga gagaatacaa aaacaattca aaaatgttga aatttcagtt 
                 180 
               
               
                   
               
               
                 tcttcttatg atactgcgtg ggttgccatg gttccatcac ctaattctcc aaagtctcca 
                 240 
               
               
                   
               
               
                 tgtttcccag aatgtttgaa ttggctgatt aacaaccagt tgaatgatgg atcttggggt 
                 300 
               
               
                   
               
               
                 ttagtcaatc acacgcacaa tcacaaccat ccacttttga aagattcttt atcctcaact 
                 360 
               
               
                   
               
               
                 ttggcttgca tcgtggccct aaagagatgg aacgtaggtg aggatcagat taacaagggg 
                 420 
               
               
                   
               
               
                 cttagtttca ttgaatctaa cttggcttcc gcgactgaaa aatctcaacc atctccaata 
                 480 
               
               
                   
               
               
                 ggattcgata tcatctttcc aggtctgtta gagtacgcca aaaatctaga tatcaactta 
                 540 
               
               
                   
               
               
                 ctgtctaagc aaactgattt ctcactaatg ttacacaaga gagaattaga acaaaagaga 
                 600 
               
               
                   
               
               
                 tgtcattcaa acgaaatgga tggttaccta gcttatatct ctgaaggtct tggtaatctt 
                 660 
               
               
                   
               
               
                 tacgattgga atatggtgaa aaagtaccag atgaaaaatg gctcagtttt caattcccct 
                 720 
               
               
                   
               
               
                 tctgcaactg cggcagcatt cattaaccat caaaatccag gatgcctgaa ctatttgaat 
                 780 
               
               
                   
               
               
                 tcactactag acaaattcgg caacgcagtt ccaactgtat accctcacga tttgtttatc 
                 840 
               
               
                   
               
               
                 agattgagta tggtggatac aattgaaaga cttggtatat cccaccactt tagagtcgag 
                 900 
               
               
                   
               
               
                 atcaaaaatg ttttggatga gacataccgt tgttgggtgg agagagatga acaaatcttt 
                 960 
               
               
                   
               
               
                 atggatgttg tgacgtgcgc gttggccttt agattgttgc gtattaacgg ttacgaagtt 
                 1020 
               
               
                   
               
               
                 agtccagatc cacttgccga aattacaaac gaattagctt taaaggatga atacgccgct 
                 1080 
               
               
                   
               
               
                 cttgaaacat atcatgcgtc acatatcctt taccaagagg acttatcatc tggaaaacaa 
                 1140 
               
               
                   
               
               
                 attcttaaat ctgctgattt cctgaaggaa atcatatcca ctgatagtaa tagactgtcc 
                 1200 
               
               
                   
               
               
                 aaactgatcc ataaagaggt tgaaaatgca cttaagttcc ctattaacac cggcttagaa 
                 1260 
               
               
                   
               
               
                 cgtattaaca caagacgtaa catccagctt tacaacgtag acaatactag aatcttgaaa 
                 1320 
               
               
                   
               
               
                 accacttacc attcttccaa catatcaaac actgattacc taagattagc tgttgaagat 
                 1380 
               
               
                   
               
               
                 ttctacacat gtcagtctat ctatagagaa gagctgaaag gattagagag atgggtcgtt 
                 1440 
               
               
                   
               
               
                 gagaataagc tagatcaatt gaaatttgcc agacaaaaga cagcttattg ttacttctca 
                 1500 
               
               
                   
               
               
                 gttgccgcca ctttatcaag tccagaattg tcagatgcac gtatttcttg ggctaaaaac 
                 1560 
               
               
                   
               
               
                 ggaattttga caactgttgt tgatgatttc tttgatattg gcgggacaat cgacgaattg 
                 1620 
               
               
                   
               
               
                 acaaacctga ttcaatgcgt tgaaaagtgg aatgtcgatg tcgataaaga ctgttgctca 
                 1680 
               
               
                   
               
               
                 gaacatgtta gaatactgtt cttggctctg aaagatgcta tctgttggat cggggatgag 
                 1740 
               
               
                   
               
               
                 gctttcaaat ggcaagctag agatgtgacg tctcacgtca ttcaaacctg gctagaactg 
                 1800 
               
               
                   
               
               
                 atgaactcta tgttgagaga agcaatttgg actagagatg catacgttcc tacattaaac 
                 1860 
               
               
                   
               
               
                 gagtatatgg aaaacgctta tgtctccttt gctttgggtc ctatcgttaa gcctgccata 
                 1920 
               
               
                   
               
               
                 tactttgtag gaccaaagct atccgaggaa atcgtcgaat catcagaata ccataacttg 
                 1980 
               
               
                   
               
               
                 ttcaagttaa tgtccacaca aggcagatta cttaatgata ttcattcttt caaaagagag 
                 2040 
               
               
                   
               
               
                 tttaaggaag gaaagttaaa tgctgttgct ctgcatcttt ctaatggcga aagtggtaaa 
                 2100 
               
               
                   
               
               
                 gtcgaagagg aagtagttga ggaaatgatg atgatgatca aaaacaagag aaaggagttg 
                 2160 
               
               
                   
               
               
                 atgaaactaa tcttcgaaga gaacggttca attgttccta gagcatgtaa ggatgcattt 
                 2220 
               
               
                   
               
               
                 tggaacatgt gtcatgtgct aaactttttc tacgcaaacg acgatggttt tactgggaac 
                 2280 
               
               
                   
               
               
                 acaatactag atacagtaaa agacatcata tacaaccctt tggtcttagt aaacgaaaac 
                 2340 
               
               
                   
               
               
                 gaggagcaaa gataa 
                 2355 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 44 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MNLSLCIASP LLTKSNRPAA LSAIHTASTS HGGQTNPTNL IIDTTKERIQ KQFKNVEISV 
                 60 
               
               
                   
               
               
                 SSYDTAWVAM VPSPNSPKSP CFPECLNWLI NNQLNDGSWG LVNHTHNHNH PLLKDSLSST 
                 120 
               
               
                   
               
               
                 LACIVALKRW NVGEDQINKG LSFIESNLAS ATEKSQPSPI GFDIIFPGLL EYAKNLDINL 
                 180 
               
               
                   
               
               
                 LSKQTDFSLM LHKRELEQKR CHSNEMDGYL AYISEGLGNL YDWNMVKKYQ MKNGSVFNSP 
                 240 
               
               
                   
               
               
                 SATAAAFINH QNPGCLNYLN SLLDKFGNAV PTVYPHDLFI RLSMVDTIER LGISHHFRVE 
                 300 
               
               
                   
               
               
                 IKNVLDETYR CWVERDEQIF MDVVTCALAF RLLRINGYEV SPDPLAEITN ELALKDEYAA 
                 360 
               
               
                   
               
               
                 LETYHASHIL YQEDLSSGKQ ILKSADFLKE IISTDSNRLS KLIHKEVENA LKFPINTGLE 
                 420 
               
               
                   
               
               
                 RINTRRNIQL YNVDNTRILK TTYHSSNISN TDYLRLAVED FYTCQSIYRE ELKGLERWVV 
                 480 
               
               
                   
               
               
                 ENKLDQLKFA RQKTAYCYFS VAATLSSPEL SDARISWAKN GILTTVVDDF FDIGGTIDEL 
                 540 
               
               
                   
               
               
                 TNLIQCVEKW NVDVDKDCCS EHVRILFLAL KDAICWIGDE AFKWQARDVT SHVIQTWLEL 
                 600 
               
               
                   
               
               
                 MNSMLREAIW TRDAYVPTLN EYMENAYVSF ALGPIVKPAI YFVGPKLSEE IVESSEYHNL 
                 660 
               
               
                   
               
               
                 FKLMSTQGRL LNDIHSFKRE FKEGKLNAVA LHLSNGESGK VEEEVVEEMM MMIKNKRKEL 
                 720 
               
               
                   
               
               
                 MKLIFEENGS IVPRACKDAF WNMCHVLNFF YANDDGFTGN TILDTVKDII YNPLVLVNEN 
                 780 
               
               
                   
               
               
                 EEQR 
                 784 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 45 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgaatctgt ccctttgtat agctagtcca ctgttgacaa aatcttctag accaactgct 
                 60 
               
               
                   
               
               
                 ctttctgcaa ttcatactgc cagtactagt catggaggtc aaacaaaccc aacaaatttg 
                 120 
               
               
                   
               
               
                 ataatcgata ctactaagga gagaatccaa aagctattca aaaatgttga aatctcagta 
                 180 
               
               
                   
               
               
                 tcatcttatg acaccgcatg ggttgcaatg gtgccatcac ctaattcccc aaaaagtcca 
                 240 
               
               
                   
               
               
                 tgttttccag agtgcttgaa ttggttaatc aataatcagt taaacgatgg ttcttggggt 
                 300 
               
               
                   
               
               
                 ttagtcaacc acactcataa ccacaatcat ccattattga aggactcttt atcatcaaca 
                 360 
               
               
                   
               
               
                 ttagcctgta ttgttgcatt gaaaagatgg aatgtaggtg aagatcaaat caacaagggt 
                 420 
               
               
                   
               
               
                 ttatcattca tagaatccaa tctagcttct gctaccgaca aatcacaacc atctccaatc 
                 480 
               
               
                   
               
               
                 gggttcgaca taatcttccc tggtttgctg gagtatgcca aaaaccttga tatcaactta 
                 540 
               
               
                   
               
               
                 ctgtctaaac aaacagattt ctctttgatg ctacacaaaa gagagttaga gcagaaaaga 
                 600 
               
               
                   
               
               
                 tgccattcta acgaaattga cgggtactta gcatatatct cagaaggttt gggtaatttg 
                 660 
               
               
                   
               
               
                 tatgactgga acatggtcaa aaagtatcag atgaaaaatg gatccgtatt caattctcct 
                 720 
               
               
                   
               
               
                 tctgcaactg ccgcagcatt cattaatcat caaaaccctg ggtgtcttaa ctacttgaac 
                 780 
               
               
                   
               
               
                 tcactattag ataagtttgg aaatgcagtt ccaacagtct atcctttgga cttgtacatc 
                 840 
               
               
                   
               
               
                 agattatcta tggttgacac tatagagaga ttaggtattt ctcatcattt cagagttgag 
                 900 
               
               
                   
               
               
                 atcaaaaatg ttttggacga gacatacaga tgttgggtcg aaagagatga gcaaatcttt 
                 960 
               
               
                   
               
               
                 atggatgtcg tgacctgcgc tctggctttt agattgctaa ggatacacgg atacaaagta 
                 1020 
               
               
                   
               
               
                 tctcctgatc aactggctga gattacaaac gaactggctt tcaaagacga atacgccgca 
                 1080 
               
               
                   
               
               
                 ttagaaacat accatgcatc ccaaatactt taccaggaag acctaagttc aggaaaacaa 
                 1140 
               
               
                   
               
               
                 atcttgaagt ctgcagattt cctgaaaggc attctgtcta cagatagtaa taggttgtct 
                 1200 
               
               
                   
               
               
                 aaattgatac acaaggaagt agaaaacgca ctaaagtttc ctattaacac tggtttagag 
                 1260 
               
               
                   
               
               
                 agaatcaata ctaggagaaa cattcagctg tacaacgtag ataatacaag gattcttaag 
                 1320 
               
               
                   
               
               
                 accacctacc atagttcaaa catttccaac acctattact taagattagc tgtcgaagac 
                 1380 
               
               
                   
               
               
                 ttttacactt gtcaatcaat ctacagagag gagttaaagg gcctagaaag atgggtagtt 
                 1440 
               
               
                   
               
               
                 caaaacaagt tggatcaact gaagtttgct agacagaaga cagcatactg ttatttctct 
                 1500 
               
               
                   
               
               
                 gttgctgcta ccctttcatc cccagaattg tctgatgcca gaataagttg ggccaaaaat 
                 1560 
               
               
                   
               
               
                 ggtattctta caactgtagt cgatgatttc tttgatattg gaggtactat tgatgaactg 
                 1620 
               
               
                   
               
               
                 acaaatctta ttcaatgtgt tgaaaagtgg aacgtggatg tagataagga ttgctgcagt 
                 1680 
               
               
                   
               
               
                 gaacatgtga gaatactttt cctggctcta aaagatgcaa tatgttggat tggcgacgag 
                 1740 
               
               
                   
               
               
                 gccttcaagt ggcaagctag agatgttaca tctcatgtca tccaaacttg gcttgaactg 
                 1800 
               
               
                   
               
               
                 atgaactcaa tgctaagaga agcaatctgg acaagagatg catacgttcc aacattgaac 
                 1860 
               
               
                   
               
               
                 gaatacatgg aaaacgctta cgtctcattt gccttgggtc ctattgttaa gccagccata 
                 1920 
               
               
                   
               
               
                 tactttgttg ggccaaagtt atccgaagag attgttgagt cttccgaata tcataaccta 
                 1980 
               
               
                   
               
               
                 ttcaagttaa tgtcaacaca aggcagactt ctgaacgata tccactcctt caaaagagaa 
                 2040 
               
               
                   
               
               
                 ttcaaggaag gtaagctaaa cgctgttgct ttgcacttgt ctaatggtga atctggcaaa 
                 2100 
               
               
                   
               
               
                 gtggaagagg aagtcgttga ggaaatgatg atgatgatca aaaacaagag aaaggaattg 
                 2160 
               
               
                   
               
               
                 atgaaattga ttttcgagga aaatggttca atcgtaccta gagcttgtaa agatgctttt 
                 2220 
               
               
                   
               
               
                 tggaatatgt gccatgttct taacttcttt tacgctaatg atgatggctt cactggaaat 
                 2280 
               
               
                   
               
               
                 acaatattgg atacagttaa agatatcatc tacaacccac ttgttttggt caatgagaac 
                 2340 
               
               
                   
               
               
                 gaggaacaaa gataa 
                 2355 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 46 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MNLSLCIASP LLTKSSRPTA LSAIHTASTS HGGQTNPTNL IIDTTKERIQ KLFKNVEISV 
                 60 
               
               
                   
               
               
                 SSYDTAWVAM VPSPNSPKSP CFPECLNWLI NNQLNDGSWG LVNHTHNHNH PLLKDSLSST 
                 120 
               
               
                   
               
               
                 LACIVALKRW NVGEDQINKG LSFIESNLAS ATDKSQPSPI GFDIIFPGLL EYAKNLDINL 
                 180 
               
               
                   
               
               
                 LSKQTDFSLM LHKRELEQKR CHSNEIDGYL AYISEGLGNL YDWNMVKKYQ MKNGSVFNSP 
                 240 
               
               
                   
               
               
                 SATAAAFINH QNPGCLNYLN SLLDKFGNAV PTVYPLDLYI RLSMVDTIER LGISHHFRVE 
                 300 
               
               
                   
               
               
                 IKNVLDETYR CWVERDEQIF MDVVTCALAF RLLRIHGYKV SPDQLAEITN ELAFKDEYAA 
                 360 
               
               
                   
               
               
                 LETYHASQIL YQEDLSSGKQ ILKSADFLKG ILSTDSNRLS KLIHKEVENA LKFPINTGLE 
                 420 
               
               
                   
               
               
                 RINTRRNIQL YNVDNTRILK TTYHSSNISN TYYLRLAVED FYTCQSIYRE ELKGLERWVV 
                 480 
               
               
                   
               
               
                 QNKLDQLKFA RQKTAYCYFS VAATLSSPEL SDARISWAKN GILTTVVDDF FDIGGTIDEL 
                 540 
               
               
                   
               
               
                 TNLIQCVEKW NVDVDKDCCS EHVRILFLAL KDAICWIGDE AFKWQARDVT SHVIQTWLEL 
                 600 
               
               
                   
               
               
                 MNSMLREAIW TRDAYVPTLN EYMENAYVSF ALGPIVKPAI YFVGPKLSEE IVESSEYHNL 
                 660 
               
               
                   
               
               
                 FKLMSTQGRL LNDIHSFKRE FKEGKLNAVA LHLSNGESGK VEEEVVEEMM MMIKNKRKEL 
                 720 
               
               
                   
               
               
                 MKLIFEENGS IVPRACKDAF WNMCHVLNFF YANDDGFTGN TILDTVKDII YNPLVLVNEN 
                 780 
               
               
                   
               
               
                 EEQR 
                 784 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 47 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggctatgc cagtgaagct aacacctgcg tcattatcct taaaagctgt gtgctgcaga 
                 60 
               
               
                   
               
               
                 ttctcatccg gtggccatgc tttgagattc gggagtagtc tgccatgttg gagaaggacc 
                 120 
               
               
                   
               
               
                 cctacccaaa gatctacttc ttcctctact actagaccag ctgccgaagt gtcatcaggt 
                 180 
               
               
                   
               
               
                 aagagtaaac aacatgatca ggaagctagt gaagcgacta tcagacaaca attacaactt 
                 240 
               
               
                   
               
               
                 gtggatgtcc tggagaatat gggaatatcc agacattttg ctgcagagat aaagtgcata 
                 300 
               
               
                   
               
               
                 ctagacagaa cttacagatc ttggttacaa agacacgagg aaatcatgct ggacactatg 
                 360 
               
               
                   
               
               
                 acatgtgcta tggcttttag aatcctaaga ttgaacggat acaacgtttc atcagatgaa 
                 420 
               
               
                   
               
               
                 ctataccacg ttgtagaggc atctggtctg cataattctt tgggtgggta tcttaacgat 
                 480 
               
               
                   
               
               
                 accagaacac tacttgaatt acacaaggct tcaacagtta gtatctctga ggatgaatct 
                 540 
               
               
                   
               
               
                 atcttagatt caattggctc tagatccaga acattgctta gagaacaatt ggagtctggt 
                 600 
               
               
                   
               
               
                 ggcgcactga gaaagccttc tttattcaaa gaggttgaac atgcactgga tggacctttt 
                 660 
               
               
                   
               
               
                 tacaccacac ttgatagact tcatcatagg tggaatattg aaaacttcaa cattattgag 
                 720 
               
               
                   
               
               
                 caacacatgt tggagactcc atacttatct aaccagcata catcaaggga tatcctagca 
                 780 
               
               
                   
               
               
                 ttgtcaatta gagatttttc ctcctcacaa ttcacttatc aacaagagct acagcatctg 
                 840 
               
               
                   
               
               
                 gagagttggg ttaaggaatg tagattagat caactacagt tcgcaagaca gaaattagcg 
                 900 
               
               
                   
               
               
                 tacttttacc tatcagccgc aggcaccatg ttttctcctg agctttctga tgcgagaaca 
                 960 
               
               
                   
               
               
                 ttatgggcca aaaacggggt gttgacaact attgttgatg atttctttga tgttgccggt 
                 1020 
               
               
                   
               
               
                 tctaaagagg aattggaaaa cttagtcatg ctggtcgaaa tgtgggatga acatcacaaa 
                 1080 
               
               
                   
               
               
                 gttgaattct attctgagca ggtcgaaatc atcttctctt ccatctacga ttctgtcaac 
                 1140 
               
               
                   
               
               
                 caattgggtg agaaggcctc tttggttcaa gacagatcaa ttacaaaaca ccttgttgaa 
                 1200 
               
               
                   
               
               
                 atatggttag acttgttaaa gtccatgatg acggaagttg aatggagact gtcaaaatac 
                 1260 
               
               
                   
               
               
                 gtgcctacag aaaaggaata catgattaat gcctctctta tcttcggcct aggtccaatc 
                 1320 
               
               
                   
               
               
                 gttttaccag ctttgtattt cgttggtcca aagatttcag aaagtatagt aaaggaccca 
                 1380 
               
               
                   
               
               
                 gaatatgatg aattgttcaa actaatgtca acatgtggta gattgttgaa tgacgtgcaa 
                 1440 
               
               
                   
               
               
                 acgttcgaaa gagaatacaa tgagggtaaa ctgaattctg tcagtctatt ggttcttcac 
                 1500 
               
               
                   
               
               
                 ggaggcccaa tgtctatttc agacgcaaag aggaaattac aaaagcctat tgatacgtgt 
                 1560 
               
               
                   
               
               
                 agaagagatc ttctttcttt ggtccttaga gaagagtctg tagtaccaag accatgtaag 
                 1620 
               
               
                   
               
               
                 gaactattct ggaaaatgtg taaagtgtgc tatttctttt actcaacaac tgatgggttt 
                 1680 
               
               
                   
               
               
                 tctagtcaag tcgaaagagc aaaagaggta gacgctgtca taaatgagcc actgaagttg 
                 1740 
               
               
                   
               
               
                 caaggttctc atacactggt atctgatgtt taa 
                 1773 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 48 
               
               
                 
                   Z. mays 
                 
               
            
           
           
               
               
            
               
                 MAMPVKLTPA SLSLKAVCCR FSSGGHALRF GSSLPCWRRT PTQRSTSSST TRPAAEVSSG 
                 60 
               
               
                   
               
               
                 KSKQHDQEAS EATIRQQLQL VDVLENMGIS RHFAAEIKCI LDRTYRSWLQ RHEEIMLDTM 
                 120 
               
               
                   
               
               
                 TCAMAFRILR LNGYNVSSDE LYHVVEASGL HNSLGGYLND TRTLLELHKA STVSISEDES 
                 180 
               
               
                   
               
               
                 ILDSIGSRSR TLLREQLESG GALRKPSLFK EVEHALDGPF YTTLDRLHHR WNIENFNIIE 
                 240 
               
               
                   
               
               
                 QHMLETPYLS NQHTSRDILA LSIRDFSSSQ FTYQQELQHL ESWVKECRLD QLQFARQKLA 
                 300 
               
               
                   
               
               
                 YFYLSAAGTM FSPELSDART LWAKNGVLTT IVDDFFDVAG SKEELENLVM LVEMWDEHHK 
                 360 
               
               
                   
               
               
                 VEFYSEQVEI IFSSIYDSVN QLGEKASLVQ DRSITKHLVE IWLDLLKSMM TEVEWRLSKY 
                 420 
               
               
                   
               
               
                 VPTEKEYMIN ASLIFGLGPI VLPALYFVGP KISESIVKDP EYDELFKLMS TCGRLLNDVQ 
                 480 
               
               
                   
               
               
                 TFEREYNEGK LNSVSLLVLH GGPMSISDAK RKLQKPIDTC RRDLLSLVLR EESVVPRPCK 
                 540 
               
               
                   
               
               
                 ELFWKMCKVC YFFYSTTDGF SSQVERAKEV DAVINEPLKL QGSHTLVSDV 
                 590 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 49 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgcagaact tccatggtac aaaggaaagg atcaaaaaga tgtttgacaa gattgaattg 
                 60 
               
               
                   
               
               
                 tccgtttctt cttatgatac agcctgggtt gcaatggtcc catcccctga ttgcccagaa 
                 120 
               
               
                   
               
               
                 acaccttgtt ttccagaatg tactaaatgg atcctagaaa atcagttggg tgatggtagt 
                 180 
               
               
                   
               
               
                 tggtcacttc ctcatggcaa tccacttcta gttaaagatg cattatcttc cactcttgct 
                 240 
               
               
                   
               
               
                 tgtattctgg ctcttaaaag atggggaatc ggtgaggaac agattaacaa aggactgaga 
                 300 
               
               
                   
               
               
                 ttcatagaac tcaactctgc tagtgtaacc gataacgaac aacacaaacc aattggattt 
                 360 
               
               
                   
               
               
                 gacattatct ttccaggtat gattgaatac gctatagact tagacctgaa tctaccacta 
                 420 
               
               
                   
               
               
                 aaaccaactg acattaactc catgttgcat cgtagagccc ttgaattgac atcaggtgga 
                 480 
               
               
                   
               
               
                 ggcaaaaatc tagaaggtag aagagcttac ttggcctacg tctctgaagg aatcggtaag 
                 540 
               
               
                   
               
               
                 ctgcaagatt gggaaatggc tatgaaatac caacgtaaaa acggatctct gttcaatagt 
                 600 
               
               
                   
               
               
                 ccatcaacaa ctgcagctgc attcatccat atacaagatg ctgaatgcct ccactatatt 
                 660 
               
               
                   
               
               
                 cgttctcttc tccagaaatt tggaaacgca gtccctacaa tataccctct cgatatctat 
                 720 
               
               
                   
               
               
                 gccagacttt caatggtaga tgccctggaa cgtcttggta ttgatagaca tttcagaaag 
                 780 
               
               
                   
               
               
                 gagagaaagt tcgttctgga tgaaacatac agattttggt tgcaaggaga agaggagatt 
                 840 
               
               
                   
               
               
                 ttctccgata acgcaacctg tgctttggcc ttcagaatat tgagacttaa tggttacgat 
                 900 
               
               
                   
               
               
                 gtctctcttg aagatcactt ctctaactct ctgggcggtt acttaaagga ctcaggagca 
                 960 
               
               
                   
               
               
                 gctttagaac tgtacagagc cctccaattg tcttacccag acgagtccct cctggaaaag 
                 1020 
               
               
                   
               
               
                 caaaattcta gaacttctta cttcttaaaa caaggtttat ccaatgtctc cctctgtggt 
                 1080 
               
               
                   
               
               
                 gacagattgc gtaaaaacat aattggagag gtgcatgatg ctttaaactt ttccgaccac 
                 1140 
               
               
                   
               
               
                 gctaacttac aaagattagc tattcgtaga aggattaagc attacgctac tgacgataca 
                 1200 
               
               
                   
               
               
                 aggattctaa aaacttccta cagatgctca acaatcggta accaagattt tctaaaactt 
                 1260 
               
               
                   
               
               
                 gcagtggaag atttcaatat ctgtcaatca atacaaagag aggaattcaa gcatattgaa 
                 1320 
               
               
                   
               
               
                 agatgggtcg ttgaaagacg tctagacaag ttaaagttcg ctagacaaaa agaggcctat 
                 1380 
               
               
                   
               
               
                 tgctatttct cagccgcagc aacattgttt gcccctgaat tgtctgatgc tagaatgtct 
                 1440 
               
               
                   
               
               
                 tgggccaaaa atggtgtatt gacaactgtg gttgatgatt tcttcgatgt cggaggctct 
                 1500 
               
               
                   
               
               
                 gaagaggaat tagttaactt gatagaattg atcgagcgtt gggatgtgaa tggcagtgca 
                 1560 
               
               
                   
               
               
                 gatttttgta gtgaggaagt tgagattatc tattctgcta tccactcaac tatctctgaa 
                 1620 
               
               
                   
               
               
                 ataggtgata agtcatttgg ctggcaaggt agagatgtaa agtctcaagt tatcaagatc 
                 1680 
               
               
                   
               
               
                 tggctggact tattgaaatc aatgttaact gaagctcaat ggtcttcaaa caagtctgtt 
                 1740 
               
               
                   
               
               
                 cctaccctag atgagtatat gacaaccgcc catgtttcat tcgcacttgg tccaattgta 
                 1800 
               
               
                   
               
               
                 cttccagcct tatacttcgt tggcccaaag ttgtcagaag aggttgcagg tcatcctgaa 
                 1860 
               
               
                   
               
               
                 ctactaaacc tctacaaagt cacatctact tgtggcagac tactgaatga ttggagaagt 
                 1920 
               
               
                   
               
               
                 tttaagagag aatccgagga aggtaagctc aacgctatta gtttatacat gatccactcc 
                 1980 
               
               
                   
               
               
                 ggtggtgctt ctacagaaga ggaaacaatc gaacatttca aaggtttgat tgattctcag 
                 2040 
               
               
                   
               
               
                 agaaggcaac tgttacaatt ggtgttgcaa gagaaggata gtatcatacc tagaccatgt 
                 2100 
               
               
                   
               
               
                 aaagatctat tttggaatat gattaagtta ttacacactt tctacatgaa agatgatggc 
                 2160 
               
               
                   
               
               
                 ttcacctcaa atgagatgag gaatgtagtt aaggcaatca ttaacgaacc aatctcactg 
                 2220 
               
               
                   
               
               
                 gatgaattat ga 
                 2232 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 50 
               
               
                 
                   P. trichocarpa 
                 
               
            
           
           
               
               
            
               
                 MSCIRPWFCP SSISATLTDP ASKLVTGEFK TTSLNFHGTK ERIKKMFDKI ELSVSSYDTA 
                 60 
               
               
                   
               
               
                 WVAMVPSPDC PETPCFPECT KWILENQLGD GSWSLPHGNP LLVKDALSST LACILALKRW 
                 120 
               
               
                   
               
               
                 GIGEEQINKG LRFIELNSAS VTDNEQHKPI GFDIIFPGMI EYAKDLDLNL PLKPTDINSM 
                 180 
               
               
                   
               
               
                 LHRRALELTS GGGKNLEGRR AYLAYVSEGI GKLQDWEMAM KYQRKNGSLF NSPSTTAAAF 
                 240 
               
               
                   
               
               
                 IHIQDAECLH YIRSLLQKFG NAVPTIYPLD IYARLSMVDA LERLGIDRHF RKERKFVLDE 
                 300 
               
               
                   
               
               
                 TYRFWLQGEE EIFSDNATCA LAFRILRLNG YDVSLEDHFS NSLGGYLKDS GAALELYRAL 
                 360 
               
               
                   
               
               
                 QLSYPDESLL EKQNSRTSYF LKQGLSNVSL CGDRLRKNII GEVHDALNFP DHANLQRLAI 
                 420 
               
               
                   
               
               
                 RRRIKHYATD DTRILKTSYR CSTIGNQDFL KLAVEDFNIC QSIQREEFKH IERWVVERRL 
                 480 
               
               
                   
               
               
                 DKLKFARQKE AYCYFSAAAT LFAPELSDAR MSWAKNGVLT TVVDDFFDVG GSEEELVNLI 
                 540 
               
               
                   
               
               
                 ELIERWDVNG SADFCSEEVE IIYSAIHSTI SEIGDKSFGW QGRDVKSHVI KIWLDLLKSM 
                 600 
               
               
                   
               
               
                 LTEAQWSSNK SVPTLDEYMT TAHVSFALGP IVLPALYFVG PKLSEEVAGH PELLNLYKVM 
                 660 
               
               
                   
               
               
                 STCGRLLNDW RSFKRESEEG KLNAISLYMI HSGGASTEEE TIEHFKGLID SQRRQLLQLV 
                 720 
               
               
                   
               
               
                 LQEKDSIIPR PCKDLFWNMI KLLHTFYMKD DGFTSNEMRN VVKAIINEPI SLDEL 
                 775 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 51 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgtctatca accttcgctc ctccggttgt tcgtctccga tctcagctac tttggaacga 
                 60 
               
               
                   
               
               
                 ggattggact cagaagtaca gacaagagct aacaatgtga gctttgagca aacaaaggag 
                 120 
               
               
                   
               
               
                 aagattagga agatgttgga gaaagtggag ctttctgttt cggcctacga tactagttgg 
                 180 
               
               
                   
               
               
                 gtagcaatgg ttccatcacc gagctcccaa aatgctccac ttttcccaca gtgtgtgaaa 
                 240 
               
               
                   
               
               
                 tggttattgg ataatcaaca tgaagatgga tcttggggac ttgataacca tgaccatcaa 
                 300 
               
               
                   
               
               
                 tctcttaaga aggatgtgtt atcatctaca ctggctagta tcctcgcgtt aaagaagtgg 
                 360 
               
               
                   
               
               
                 ggaattggtg aaagacaaat aaacaagggt ctccagttta ttgagctgaa ttctgcatta 
                 420 
               
               
                   
               
               
                 gtcactgatg aaaccataca gaaaccaaca gggtttgata ttatatttcc tgggatgatt 
                 480 
               
               
                   
               
               
                 aaatatgcta gagatttgaa tctgacgatt ccattgggct cagaagtggt ggatgacatg 
                 540 
               
               
                   
               
               
                 atacgaaaaa gagatctgga tcttaaatgt gatagtgaaa agttttcaaa gggaagagaa 
                 600 
               
               
                   
               
               
                 gcatatctgg cctatgtttt agaggggaca agaaacctaa aagattggga tttgatagtc 
                 660 
               
               
                   
               
               
                 aaatatcaaa ggaaaaatgg gtcactgttt gattctccag ccacaacagc agctgctttt 
                 720 
               
               
                   
               
               
                 actcagtttg ggaatgatgg ttgtctccgt tatctctgtt ctctccttca gaaattcgag 
                 780 
               
               
                   
               
               
                 gctgcagttc cttcagttta tccatttgat caatatgcac gccttagtat aattgtcact 
                 840 
               
               
                   
               
               
                 cttgaaagct taggaattga tagagatttc aaaaccgaaa tcaaaagcat attggatgaa 
                 900 
               
               
                   
               
               
                 acctatagat attggcttcg tggggatgaa gaaatatgtt tggacttggc cacttgtgct 
                 960 
               
               
                   
               
               
                 ttggctttcc gattattgct tgctcatggc tatgatgtgt cttacgatcc gctaaaacca 
                 1020 
               
               
                   
               
               
                 tttgcagaag aatctggttt ctctgatact ttggaaggat atgttaagaa tacgttttct 
                 1080 
               
               
                   
               
               
                 gtgttagaat tatttaaggc tgctcaaagt tatccacatg aatcagcttt gaagaagcag 
                 1140 
               
               
                   
               
               
                 tgttgttgga ctaaacaata tctggagatg gaattgtcca gctgggttaa gacctctgtt 
                 1200 
               
               
                   
               
               
                 cgagataaat acctcaagaa agaggtcgag gatgctcttg cttttccctc ctatgcaagc 
                 1260 
               
               
                   
               
               
                 ctagaaagat cagatcacag gagaaaaata ctcaatggtt ctgctgtgga aaacaccaga 
                 1320 
               
               
                   
               
               
                 gttacaaaaa cctcatatcg tttgcacaat atttgcacct ctgatatcct gaagttagct 
                 1380 
               
               
                   
               
               
                 gtggatgact tcaatttctg ccagtccata caccgtgaag aaatggaacg tcttgatagg 
                 1440 
               
               
                   
               
               
                 tggattgtgg agaatagatt gcaggaactg aaatttgcca gacagaagct ggcttactgt 
                 1500 
               
               
                   
               
               
                 tatttctctg gggctgcaac tttattttct ccagaactat ctgatgctcg tatatcgtgg 
                 1560 
               
               
                   
               
               
                 gccaaaggtg gagtacttac aacggttgta gacgacttct ttgatgttgg agggtccaaa 
                 1620 
               
               
                   
               
               
                 gaagaactgg aaaacctcat acacttggtc gaaaagtggg atttgaacgg tgttcctgag 
                 1680 
               
               
                   
               
               
                 tacagctcag aacatgttga gatcatattc tcagttctaa gggacaccat tctcgaaaca 
                 1740 
               
               
                   
               
               
                 ggagacaaag cattcaccta tcaaggacgc aatgtgacac accacattgt gaaaatttgg 
                 1800 
               
               
                   
               
               
                 ttggatctgc tcaagtctat gttgagagaa gccgagtggt ccagtgacaa gtcaacacca 
                 1860 
               
               
                   
               
               
                 agcttggagg attacatgga aaatgcgtac atatcatttg cattaggacc aattgtcctc 
                 1920 
               
               
                   
               
               
                 ccagctacct atctgatcgg acctccactt ccagagaaga cagtcgatag ccaccaatat 
                 1980 
               
               
                   
               
               
                 aatcagctct acaagctcgt gagcactatg ggtcgtcttc taaatgacat acaaggtttt 
                 2040 
               
               
                   
               
               
                 aagagagaaa gcgcggaagg gaagctgaat gcggtttcat tgcacatgaa acacgagaga 
                 2100 
               
               
                   
               
               
                 gacaatcgca gcaaagaagt gatcatagaa tcgatgaaag gtttagcaga gagaaagagg 
                 2160 
               
               
                   
               
               
                 gaagaattgc ataagctagt tttggaggag aaaggaagtg tggttccaag ggaatgcaaa 
                 2220 
               
               
                   
               
               
                 gaagcgttct tgaaaatgag caaagtgttg aacttatttt acaggaagga cgatggattc 
                 2280 
               
               
                   
               
               
                 acatcaaatg atctgatgag tcttgttaaa tcagtgatct acgagcctgt tagcttacag 
                 2340 
               
               
                   
               
               
                 aaagaatctt taacttga 
                 2358 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 52 
               
               
                 
                   A. thaliana 
                 
               
            
           
           
               
               
            
               
                 MSINLRSSGC SSPISATLER GLDSEVQTRA NNVSFEQTKE KIRKMLEKVE LSVSAYDTSW 
                 60 
               
               
                   
               
               
                 VAMVPSPSSQ NAPLFPQCVK WLLDNQHEDG SWGLDNHDHQ SLKKDVLSST LASILALKKW 
                 120 
               
               
                   
               
               
                 GIGERQINKG LQFIELNSAL VTDETIQKPT GFDIIFPGMI KYARDLNLTI PLGSEVVDDM 
                 180 
               
               
                   
               
               
                 IRKRDLDLKC DSEKFSKGRE AYLAYVLEGT RNLKDWDLIV KYQRKNGSLF DSPATTAAAF 
                 240 
               
               
                   
               
               
                 TQFGNDGCLR YLCSLLQKFE AAVPSVYPFD QYARLSIIVT LESLGIDRDF KTEIKSILDE 
                 300 
               
               
                   
               
               
                 TYRYWLRGDE EICLDLATCA LAFRLLLAHG YDVSYDPLKP FAEESGFSDT LEGYVKNTFS 
                 360 
               
               
                   
               
               
                 VLELFKAAQS YPHESALKKQ CCWTKQYLEM ELSSWVKTSV RDKYLKKEVE DALAFPSYAS 
                 420 
               
               
                   
               
               
                 LERSDHRRKI LNGSAVENTR VTKTSYRLHN ICTSDILKLA VDDFNFCQSI HREEMERLDR 
                 480 
               
               
                   
               
               
                 WIVENRLQEL KFARQKLAYC YFSGAATLFS PELSDARISW AKGGVLTTVV DDFFDVGGSK 
                 540 
               
               
                   
               
               
                 EELENLIHLV EKWDLNGVPE YSSEHVEIIF SVLRDTILET GDKAFTYQGR NVTHHIVKIW 
                 600 
               
               
                   
               
               
                 LDLLKSMLRE AEWSSDKSTP SLEDYMENAY ISFALGPIVL PATYLIGPPL PEKTVDSHQY 
                 660 
               
               
                   
               
               
                 NQLYKLVSTM GRLLNDIQGF KRESAEGKLN AVSLHMKHER DNRSKEVIIE SMKGLAERKR 
                 720 
               
               
                   
               
               
                 EELHKLVLEE KGSVVPRECK EAFLKMSKVL NLFYRKDDGF TSNDLMSLVK SVIYEPVSLQ 
                 780 
               
               
                   
               
               
                 KESLT 
                 785 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 53 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggaatttg atgaaccatt ggttgacgaa gcaagatctt tagtgcagcg tactttacaa 
                 60 
               
               
                   
               
               
                 gattatgatg acagatacgg cttcggtact atgtcatgtg ctgcttatga tacagcctgg 
                 120 
               
               
                   
               
               
                 gtgtctttag ttacaaaaac agtcgatggg agaaaacaat ggcttttccc agagtgtttt 
                 180 
               
               
                   
               
               
                 gaatttctac tagaaacaca atctgatgcc ggaggatggg aaatcgggaa ttcagcacca 
                 240 
               
               
                   
               
               
                 atcgacggta tattgaatac agctgcatcc ttacttgctc taaaacgtca cgttcaaact 
                 300 
               
               
                   
               
               
                 gagcaaatca tccaacctca acatgaccat aaggatctag caggtagagc tgaacgtgcc 
                 360 
               
               
                   
               
               
                 gctgcatctt tgagagcaca attggctgca ttggatgtgt ctacaactga acacgtcggt 
                 420 
               
               
                   
               
               
                 tttgagataa ttgttcctgc aatgctagac ccattagaag ccgaagatcc atctctagtt 
                 480 
               
               
                   
               
               
                 ttcgattttc cagctaggaa acctttgatg aagattcatg atgctaagat gagtagattc 
                 540 
               
               
                   
               
               
                 aggccagaat acttgtatgg caaacaacca atgaccgcct tacattcatt agaggctttc 
                 600 
               
               
                   
               
               
                 ataggcaaaa tcgacttcga taaggtaaga caccaccgta cccatgggtc tatgatgggt 
                 660 
               
               
                   
               
               
                 tctccttcat ctaccgcagc ctacttaatg cacgcttcac aatgggatgg tgactcagag 
                 720 
               
               
                   
               
               
                 gcttacctta gacacgtgat taaacacgca gcagggcagg gaactggtgc tgtaccatct 
                 780 
               
               
                   
               
               
                 gctttcccat caacacattt tgagtcatct tggattctta ccacattgtt tagagctgga 
                 840 
               
               
                   
               
               
                 ttttcagctt ctcatcttgc ctgtgatgag ttgaacaagt tggtcgagat acttgagggc 
                 900 
               
               
                   
               
               
                 tcattcgaga aggaaggtgg ggcaatcggt tacgctccag ggtttcaagc agatgttgat 
                 960 
               
               
                   
               
               
                 gatactgcta aaacaataag tacattagca gtccttggaa gagatgctac accaagacaa 
                 1020 
               
               
                   
               
               
                 atgatcaagg tatttgaagc taatacacat tttagaacat accctggtga aagagatcct 
                 1080 
               
               
                   
               
               
                 tctttgacag ctaattgtaa tgctctatca gccttactac accaaccaga tgcagcaatg 
                 1140 
               
               
                   
               
               
                 tatggatctc aaattcaaaa gattaccaaa tttgtctgtg actattggtg gaagtctgat 
                 1200 
               
               
                   
               
               
                 ggtaagatta aagataagtg gaacacttgc tacttgtacc catctgtctt attagttgag 
                 1260 
               
               
                   
               
               
                 gttttggttg atcttgttag tttattggag cagggtaaat tgcctgatgt tttggatcaa 
                 1320 
               
               
                   
               
               
                 gagcttcaat acagagtcgc catcacattg ttccaagcat gtttaaggcc attactagac 
                 1380 
               
               
                   
               
               
                 caagatgccg aaggatcatg gaacaagtct atcgaagcca cagcctacgg catccttatc 
                 1440 
               
               
                   
               
               
                 ctaactgaag ctaggagagt ttgtttcttc gacagattgt ctgagccatt gaatgaggca 
                 1500 
               
               
                   
               
               
                 atccgtagag gtatcgcttt cgccgactct atgtctggaa ctgaagctca gttgaactac 
                 1560 
               
               
                   
               
               
                 atttggatcg aaaaggttag ttacgcacct gcattattga ctaaatccta tttgttagca 
                 1620 
               
               
                   
               
               
                 gcaagatggg ctgctaagtc tcctttaggc gcttccgtag gctcttcttt gtggactcca 
                 1680 
               
               
                   
               
               
                 ccaagagaag gattggataa gcatgtcaga ttattccatc aagctgagtt attcagatcc 
                 1740 
               
               
                   
               
               
                 cttccagaat gggaattaag agcctccatg attgaagcag ctttgttcac accacttcta 
                 1800 
               
               
                   
               
               
                 agagcacata gactagacgt tttccctaga caagatgtag gtgaagacaa atatcttgat 
                 1860 
               
               
                   
               
               
                 gtagttccat tcttttggac tgccgctaac aacagagata gaacttacgc ttccactcta 
                 1920 
               
               
                   
               
               
                 ttcctttacg atatgtgttt tatcgcaatg ttaaacttcc agttagacga attcatggag 
                 1980 
               
               
                   
               
               
                 gccacagccg gtatcttatt cagagatcat atggatgatt tgaggcaatt gattcatgat 
                 2040 
               
               
                   
               
               
                 cttttggcag agaaaacttc cccaaagagt tctggtagaa gtagtcaggg cacaaaagat 
                 2100 
               
               
                   
               
               
                 gctgactcag gtatagagga agacgtgtca atgtccgatt cagcttcaga ttcccaggat 
                 2160 
               
               
                   
               
               
                 agaagtccag aatacgactt ggttttcagt gcattgagta cctttacaaa acatgtcttg 
                 2220 
               
               
                   
               
               
                 caacacccat ctatacaaag tgcctctgta tgggatagaa aactacttgc tagagagatg 
                 2280 
               
               
                   
               
               
                 aaggcttact tacttgctca tatccaacaa gcagaagatt caactccatt gtctgaattg 
                 2340 
               
               
                   
               
               
                 aaagatgtgc ctcaaaagac tgatgtaaca agagtttcta catctactac taccttcttt 
                 2400 
               
               
                   
               
               
                 aactgggtta gaacaacttc cgcagaccat atatcctgcc catactcctt ccactttgta 
                 2460 
               
               
                   
               
               
                 gcatgccatc taggcgcagc attgtcacct aaagggtcta acggtgattg ctatccttca 
                 2520 
               
               
                   
               
               
                 gctggtgaga agttcttggc agctgcagtc tgcagacatt tggccaccat gtgtagaatg 
                 2580 
               
               
                   
               
               
                 tacaacgatc ttggatcagc tgaacgtgat tctgatgaag gtaatttgaa ctccttggac 
                 2640 
               
               
                   
               
               
                 ttccctgaat tcgccgattc cgcaggaaac ggagggatag aaattcagaa ggccgctcta 
                 2700 
               
               
                   
               
               
                 ttaaggttag ctgagtttga gagagattca tacttagagg ccttccgtcg tttacaagat 
                 2760 
               
               
                   
               
               
                 gaatccaata gagttcacgg tccagccggt ggtgatgaag ccagattgtc cagaaggaga 
                 2820 
               
               
                   
               
               
                 atggcaatcc ttgaattctt cgcccagcag gtagatttgt acggtcaagt atacgtcatt 
                 2880 
               
               
                   
               
               
                 agggatattt ccgctcgtat tcctaaaaac gaggttgaga aaaagagaaa attggatgat 
                 2940 
               
               
                   
               
               
                 gctttcaatt ga 
                 2952 
               
               
                   
               
               
                 SEQ ID NO: 54 
                   
               
               
                 
                   P. amygdali 
                 
                   
               
               
                 MEFDEPLVDE ARSLVQRTLQ DYDDRYGFGT MSCAAYDTAW VSLVTKTVDG RKQWLFPECF 
                 60 
               
               
                   
               
               
                 EFLLETQSDA GGWEIGNSAP IDGILNTAAS LLALKRHVQT EQIIQPQHDH KDLAGRAERA 
                 120 
               
               
                   
               
               
                 AASLRAQLAA LDVSTTEHVG FEIIVPAMLD PLEAEDPSLV FDFPARKPLM KIHDAKMSRF 
                 180 
               
               
                   
               
               
                 RPEYLYGKQP MTALHSLEAF IGKIDFDKVR HHRTHGSMMG SPSSTAAYLM HASQWDGDSE 
                 240 
               
               
                   
               
               
                 AYLRHVIKHA AGQGTGAVPS AFPSTHFESS WILTTLFRAG FSASHLACDE LNKLVEILEG 
                 300 
               
               
                   
               
               
                 SFEKEGGAIG YAPGFQADVD DTAKTISTLA VLGRDATPRQ MIKVFEANTH FRTYPGERDP 
                 360 
               
               
                   
               
               
                 SLTANCNALS ALLHQPDAAM YGSQIQKITK FVCDYWWKSD GKIKDKWNTC YLYPSVLLVE 
                 420 
               
               
                   
               
               
                 VLVDLVSLLE QGKLPDVLDQ ELQYRVAITL FQACLRPLLD QDAEGSWNKS IEATAYGILI 
                 480 
               
               
                   
               
               
                 LTEARRVCFF DRLSEPLNEA IRRGIAFADS MSGTEAQLNY IWIEKVSYAP ALLTKSYLLA 
                 540 
               
               
                   
               
               
                 ARWAAKSPLG ASVGSSLWTP PREGLDKHVR LFHQAELFRS LPEWELRASM IEAALFTPLL 
                 600 
               
               
                   
               
               
                 RAHRLDVFPR QDVGEDKYLD VVPFFWTAAN NRDRTYASTL FLYDMCFIAM LNFQLDEFME 
                 660 
               
               
                   
               
               
                 ATAGILFRDH MDDLRQLIHD LLAEKTSPKS SGRSSQGTKD ADSGIEEDVS MSDSASDSQD 
                 720 
               
               
                   
               
               
                 RSPEYDLVFS ALSTFTKHVL QHPSIQSASV WDRKLLAREM KAYLLAHIQQ AEDSTPLSEL 
                 780 
               
               
                   
               
               
                 KDVPQKTDVT RVSTSTTTFF NWVRTTSADH ISCPYSFHFV ACHLGAALSP KGSNGDCYPS 
                 840 
               
               
                   
               
               
                 AGEKFLAAAV CRHLATMCRM YNDLGSAERD SDEGNLNSLD FPEFADSAGN GGIEIQKAAL 
                 900 
               
               
                   
               
               
                 LRLAEFERDS YLEAFRRLQD ESNRVHGPAG GDEARLSRRR MAILEFFAQQ VDLYGQVYVI 
                 960 
               
               
                   
               
               
                 RDISARIPKN EVEKKRKLDD AFN 
                 983 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 55 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggcttcta gtacacttat ccaaaacaga tcatgtggcg tcacatcatc tatgtcaagt 
                 60 
               
               
                   
               
               
                 tttcaaatct tcagaggtca accactaaga tttcctggca ctagaacccc agctgcagtt 
                 120 
               
               
                   
               
               
                 caatgcttga aaaagaggag atgccttagg ccaaccgaat ccgtactaga atcatctcct 
                 180 
               
               
                   
               
               
                 ggctctggtt catatagaat agtaactggc ccttctggaa ttaaccctag ttctaacggg 
                 240 
               
               
                   
               
               
                 cacttgcaag agggttcctt gactcacagg ttaccaatac caatggaaaa atctatcgat 
                 300 
               
               
                   
               
               
                 aacttccaat ctactctata tgtgtcagat atttggtctg aaacactaca gagaactgaa 
                 360 
               
               
                   
               
               
                 tgtttgctac aagtaactga aaacgtccag atgaatgagt ggattgagga aattagaatg 
                 420 
               
               
                   
               
               
                 tactttagaa atatgacttt aggtgaaatt tccatgtccc cttacgacac tgcttgggtg 
                 480 
               
               
                   
               
               
                 gctagagttc cagcgttgga cggttctcat gggcctcaat tccacagatc tttgcaatgg 
                 540 
               
               
                   
               
               
                 attatcgaca accaattacc agatggggac tggggcgaac cttctctttt cttgggttac 
                 600 
               
               
                   
               
               
                 gatagagttt gtaatacttt agcctgtgtg attgcgttga aaacatgggg tgttggggca 
                 660 
               
               
                   
               
               
                 caaaacgttg aaagaggaat tcagttccta caatctaaca tatacaagat ggaggaagat 
                 720 
               
               
                   
               
               
                 gacgctaatc atatgccaat aggattcgaa atcgtattcc ctgctatgat ggaagatgcc 
                 780 
               
               
                   
               
               
                 aaagcattag gtttggattt gccatacgat gctactattt tgcaacagat ttcagccgaa 
                 840 
               
               
                   
               
               
                 agagagaaaa agatgaaaaa gatcccaatg gcaatggtgt acaaataccc aaccacttta 
                 900 
               
               
                   
               
               
                 cttcactcct tagaaggctt gcatagagaa gttgattgga ataagttgtt acaattacaa 
                 960 
               
               
                   
               
               
                 tctgaaaatg gtagttttct ttattcacct gcttcaaccg catgcgcctt aatgtacact 
                 1020 
               
               
                   
               
               
                 aaggacgtta aatgttttga ttacttaaac cagttgttga tcaagttcga ccacgcatgc 
                 1080 
               
               
                   
               
               
                 ccaaatgtat atccagtcga tctattcgaa agattatgga tggttgacag attgcagaga 
                 1140 
               
               
                   
               
               
                 ttagggatct ccagatactt tgaaagagag attagagatt gtttacaata cgtctacaga 
                 1200 
               
               
                   
               
               
                 tattggaaag attgtggaat cggatgggct tctaactctt ccgtacaaga tgttgatgat 
                 1260 
               
               
                   
               
               
                 acagccatgg cgtttagact tttaaggact catggtttcg acgtaaagga agattgcttt 
                 1320 
               
               
                   
               
               
                 agacagtttt tcaaggacgg agaattcttc tgcttcgcag gccaatcatc tcaagcagtt 
                 1380 
               
               
                   
               
               
                 acaggcatgt ttaatctttc aagagccagt caaacattgt ttccaggaga atctttattg 
                 1440 
               
               
                   
               
               
                 aaaaaggcta gaaccttctc tagaaacttc ttgagaacaa agcatgagaa caacgaatgt 
                 1500 
               
               
                   
               
               
                 ttcgataaat ggatcattac taaagatttg gctggtgaag tcgagtataa cttgaccttc 
                 1560 
               
               
                   
               
               
                 ccatggtatg cctctttgcc tagattagaa cataggacat acttagatca atatggaatc 
                 1620 
               
               
                   
               
               
                 gatgatatct ggataggcaa atctttatac aaaatgcctg ctgttaccaa cgaagttttc 
                 1680 
               
               
                   
               
               
                 ctaaagttgg caaaggcaga ctttaacatg tgtcaagctc tacacaaaaa ggaattggaa 
                 1740 
               
               
                   
               
               
                 caagtgataa agtggaacgc gtcctgtcaa ttcagagatc ttgaattcgc cagacaaaaa 
                 1800 
               
               
                   
               
               
                 tcagtagaat gctattttgc tggtgcagcc acaatgttcg aaccagaaat ggttcaagct 
                 1860 
               
               
                   
               
               
                 agattagtct gggcaagatg ttgtgtattg acaactgtct tagacgatta ctttgaccac 
                 1920 
               
               
                   
               
               
                 gggacacctg ttgaggaact tagagtgttt gttcaagctg tcagaacatg gaatccagag 
                 1980 
               
               
                   
               
               
                 ttgatcaacg gtttgccaga gcaagctaaa atcttgttta tgggcttata caaaacagtt 
                 2040 
               
               
                   
               
               
                 aacacaattg cagaggaagc attcatggca cagaaaagag acgtccatca tcatttgaaa 
                 2100 
               
               
                   
               
               
                 cactattggg acaagttgat aacaagtgcc ctaaaggagg ccgaatgggc agagtcaggt 
                 2160 
               
               
                   
               
               
                 tacgtcccaa catttgatga atacatggaa gtagctgaaa tttctgttgc tctagaacca 
                 2220 
               
               
                   
               
               
                 attgtctgta gtaccttgtt ctttgcgggt catagactag atgaggatgt tctagatagt 
                 2280 
               
               
                   
               
               
                 tacgattacc atctagttat gcatttggta aacagagtcg gtagaatctt gaatgatata 
                 2340 
               
               
                   
               
               
                 caaggcatga agagggaggc ttcacaaggt aagatctcat cagttcaaat ctacatggag 
                 2400 
               
               
                   
               
               
                 gaacatccat ctgttccatc tgaggccatg gcgatcgctc atcttcaaga gttagttgat 
                 2460 
               
               
                   
               
               
                 aattcaatgc agcaattgac atacgaagtt cttaggttca ctgcggttcc aaaaagttgt 
                 2520 
               
               
                   
               
               
                 aagagaatcc acttgaatat ggctaaaatc atgcatgcct tctacaagga tactgatgga 
                 2580 
               
               
                   
               
               
                 ttctcatccc ttactgcaat gacaggattc gtcaaaaagg ttcttttcga acctgtgcct 
                 2640 
               
               
                   
               
               
                 gagtaa 
                 2646 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 56 
               
               
                 
                   P. patens 
                 
               
            
           
           
               
               
            
               
                 MASSTLIQNR SCGVTSSMSS FQIFRGQPLR FPGTRTPAAV QCLKKRRCLR PTESVLESSP 
                 60 
               
               
                   
               
               
                 GSGSYRIVTG PSGINPSSNG HLQEGSLTHR LPIPMEKSID NFQSTLYVSD IWSETLQRTE 
                 120 
               
               
                   
               
               
                 CLLQVTENVQ MNEWIEEIRM YFRNMTLGEI SMSPYDTAWV ARVPALDGSH GPQFHRSLQW 
                 180 
               
               
                   
               
               
                 IIDNQLPDGD WGEPSLFLGY DRVCNTLACV IALKTWGVGA QNVERGIQFL QSNIYKMEED 
                 240 
               
               
                   
               
               
                 DANHMPIGFE IVFPAMMEDA KALGLDLPYD ATILQQISAE REKKMKKIPM AMVYKYPTTL 
                 300 
               
               
                   
               
               
                 LHSLEGLHRE VDWNKLLQLQ SENGSFLYSP ASTACALMYT KDVKCFDYLN QLLIKFDHAC 
                 360 
               
               
                   
               
               
                 PNVYPVDLFE RLWMVDRLQR LGISRYFERE IRDCLQYVYR YWKDCGIGWA SNSSVQDVDD 
                 420 
               
               
                   
               
               
                 TAMAFRLLRT HGFDVKEDCF RQFFKDGEFF CFAGQSSQAV TGMFNLSRAS QTLFPGESLL 
                 480 
               
               
                   
               
               
                 KKARTFSRNF LRTKHENNEC FDKWIITKDL AGEVEYNLTF PWYASLPRLE HRTYLDQYGI 
                 540 
               
               
                   
               
               
                 DDIWIGKSLY KMPAVTNEVF LKLAKADFNM CQALHKKELE QVIKWNASCQ FRDLEFARQK 
                 600 
               
               
                   
               
               
                 SVECYFAGAA TMFEPEMVQA RLVWARCCVL TTVLDDYFDH GTPVEELRVF VQAVRTWNPE 
                 660 
               
               
                   
               
               
                 LINGLPEQAK ILFMGLYKTV NTIAEEAFMA QKRDVHHHLK HYWDKLITSA LKEAEWAESG 
                 720 
               
               
                   
               
               
                 YVPTFDEYME VAEISVALEP IVCSTLFFAG HRLDEDVLDS YDYHLVMHLV NRVGRILNDI 
                 780 
               
               
                   
               
               
                 QGMKREASQG KISSVQIYME EHPSVPSEAM AIAHLQELVD NSMQQLTYEV LRFTAVPKSC 
                 840 
               
               
                   
               
               
                 KRIHLNMAKI MHAFYKDTDG FSSLTAMTGF VKKVLFEPVP E 
                 881 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 57 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgcctggta aaattgaaaa tggtacccca aaggacctca agactggaaa tgattttgtt 
                 60 
               
               
                   
               
               
                 tctgctgcta agagtttact agatcgagct ttcaaaagtc atcattccta ctacggatta 
                 120 
               
               
                   
               
               
                 tgctcaactt catgtcaagt ttatgataca gcttgggttg caatgattcc aaaaacaaga 
                 180 
               
               
                   
               
               
                 gataatgtaa aacagtggtt gtttccagaa tgtttccatt acctcttaaa aacacaagcc 
                 240 
               
               
                   
               
               
                 gcagatggct catggggttc attgcctaca acacagacag cgggtatcct agatacagcc 
                 300 
               
               
                   
               
               
                 tcagctgtgc tggcattatt gtgccacgca caagagcctt tacaaatatt ggatgtatct 
                 360 
               
               
                   
               
               
                 ccagatgaaa tggggttgag aatagaacac ggtgtcacat ccttgaaacg tcaattagca 
                 420 
               
               
                   
               
               
                 gtttggaatg atgtggagga caccaaccat attggcgtcg agtttatcat accagcctta 
                 480 
               
               
                   
               
               
                 ctttccatgc tagaaaagga attagatgtt ccatcttttg aatttccatg taggtccatc 
                 540 
               
               
                   
               
               
                 ttagagagaa tgcacgggga gaaattaggt catttcgacc tggaacaagt ttacggcaag 
                 600 
               
               
                   
               
               
                 ccaagctcat tgttgcactc attggaagca tttctcggta agctagattt tgatcgacta 
                 660 
               
               
                   
               
               
                 tcacatcacc tataccacgg cagtatgatg gcatctccat cttcaacggc tgcttatctt 
                 720 
               
               
                   
               
               
                 attggggcta caaaatggga tgacgaagcc gaagattacc taagacatgt aatgcgtaat 
                 780 
               
               
                   
               
               
                 ggtgcaggac atgggaatgg aggtatttct ggtacatttc caactactca tttcgaatgt 
                 840 
               
               
                   
               
               
                 agctggatta tagcaacgtt gttaaaggtt ggctttactt tgaagcaaat tgacggcgat 
                 900 
               
               
                   
               
               
                 ggcttaagag gtttatcaac catcttactt gaggcgcttc gtgatgagaa tggtgtcata 
                 960 
               
               
                   
               
               
                 ggctttgccc ctagaacagc agatgtagat gacacagcca aagctctatt ggccttgtca 
                 1020 
               
               
                   
               
               
                 ttggtaaacc agccagtgtc acctgatatc atgattaagg tctttgaggg caaagaccat 
                 1080 
               
               
                   
               
               
                 tttaccactt ttggttcaga aagagatcca tcattgactt ccaacctgca cgtcctttta 
                 1140 
               
               
                   
               
               
                 tctttactta aacaatctaa cttgtctcaa taccatcctc aaatcctcaa aacaacatta 
                 1200 
               
               
                   
               
               
                 ttcacttgta gatggtggtg gggttccgat cattgtgtca aagacaaatg gaatttgagt 
                 1260 
               
               
                   
               
               
                 cacctatatc caactatgtt gttggttgaa gccttcactg aagtgctcca tctcattgac 
                 1320 
               
               
                   
               
               
                 ggtggtgaat tgtctagtct gtttgatgaa tcctttaagt gtaagattgg tcttagcatc 
                 1380 
               
               
                   
               
               
                 tttcaagcgg tacttagaat aatcctcacc caagacaacg acggctcttg gagaggatac 
                 1440 
               
               
                   
               
               
                 agagaacaga cgtgttacgc aatattggct ttagttcaag cgagacatgt atgctttttc 
                 1500 
               
               
                   
               
               
                 actcacatgg ttgacagact gcaatcatgt gttgatcgag gtttctcatg gttgaaatct 
                 1560 
               
               
                   
               
               
                 tgctcttttc attctcaaga cctgacttgg acctctaaaa cagcttatga agtgggtttc 
                 1620 
               
               
                   
               
               
                 gtagctgaag catataaact agctgcttta caatctgctt ccctggaggt tcctgctgcc 
                 1680 
               
               
                   
               
               
                 accattggac attctgtcac gtctgccgtt ccatcaagtg atcttgaaaa atacatgaga 
                 1740 
               
               
                   
               
               
                 ttggtgagaa aaactgcgtt attctctcca ctggatgagt ggggtctaat ggcttctatc 
                 1800 
               
               
                   
               
               
                 atcgaatctt catttttcgt accattactg caggcacaaa gagttgaaat ataccctaga 
                 1860 
               
               
                   
               
               
                 gataatatca aggtggacga agataagtac ttgtctatta tcccattcac atgggtcgga 
                 1920 
               
               
                   
               
               
                 tgcaataata ggtctagaac tttcgcaagt aacagatggc tatacgatat gatgtacctt 
                 1980 
               
               
                   
               
               
                 tcattactcg gctatcaaac cgacgagtac atggaagctg tagctgggcc agtgtttggg 
                 2040 
               
               
                   
               
               
                 gatgtttcct tgttacatca aacaattgat aaggtgattg ataatacaat gggtaacctt 
                 2100 
               
               
                   
               
               
                 gcgagagcca atggaacagt acacagtggt aatggacatc agcacgaatc tcctaatata 
                 2160 
               
               
                   
               
               
                 ggtcaagtcg aggacacctt gactcgtttc acaaattcag tcttgaatca caaagacgtc 
                 2220 
               
               
                   
               
               
                 cttaactcta gctcatctga tcaagatact ttgagaagag agtttagaac attcatgcac 
                 2280 
               
               
                   
               
               
                 gctcatataa cacaaatcga agataactca cgattcagta agcaagcctc atccgatgcg 
                 2340 
               
               
                   
               
               
                 ttttcctctc ctgaacaatc ttactttcaa tgggtgaact caactggtgg ctcacatgtc 
                 2400 
               
               
                   
               
               
                 gcttgcgcct attcatttgc cttctctaat tgcctcatgt ctgcaaattt gttgcagggt 
                 2460 
               
               
                   
               
               
                 aaagacgcat ttccaagcgg aacgcaaaag tacttaatct cctctgttat gagacatgcc 
                 2520 
               
               
                   
               
               
                 acaaacatgt gtagaatgta taacgacttt ggctctattg ccagagacaa cgctgagaga 
                 2580 
               
               
                   
               
               
                 aatgttaata gtattcattt tcctgagttt actctctgta acggaacttc tcaaaaccta 
                 2640 
               
               
                   
               
               
                 gatgaaagga aggaaagact tctgaaaatc gcaacttacg aacaagggta tttggataga 
                 2700 
               
               
                   
               
               
                 gcactagagg ccttggaaag acagagtaga gatgatgccg gagacagagc tggatctaaa 
                 2760 
               
               
                   
               
               
                 gatatgagaa agttgaaaat cgttaagtta ttctgtgatg ttacggactt atacgatcag 
                 2820 
               
               
                   
               
               
                 ctctacgtta tcaaagattt gtcatcctct atgaagtaa 
                 2859 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 58 
               
               
                 
                   G. fujikuroi 
                 
               
            
           
           
               
               
            
               
                 MPGKIENGTP KDLKTGNDFV SAAKSLLDRA FKSHHSYYGL CSTSCQVYDT AWVAMIPKTR 
                 60 
               
               
                   
               
               
                 DNVKQWLFPE CFHYLLKTQA ADGSWGSLPT TQTAGILDTA SAVLALLCHA QEPLQILDVS 
                 120 
               
               
                   
               
               
                 PDEMGLRIEH GVTSLKRQLA VWNDVEDTNH IGVEFIIPAL LSMLEKELDV PSFEFPCRSI 
                 180 
               
               
                   
               
               
                 LERMHGEKLG HFDLEQVYGK PSSLLHSLEA FLGKLDFDRL SHHLYHGSMM ASPSSTAAYL 
                 240 
               
               
                   
               
               
                 IGATKWDDEA EDYLRHVMRN GAGHGNGGIS GTFPTTHFEC SWIIATLLKV GFTLKQIDGD 
                 300 
               
               
                   
               
               
                 GLRGLSTILL EALRDENGVI GFAPRTADVD DTAKALLALS LVNQPVSPDI MIKVFEGKDH 
                 360 
               
               
                   
               
               
                 FTTFGSERDP SLTSNLHVLL SLLKQSNLSQ YHPQILKTTL FTCRWWWGSD HCVKDKWNLS 
                 420 
               
               
                   
               
               
                 HLYPTMLLVE AFTEVLHLID GGELSSLFDE SFKCKIGLSI FQAVLRIILT QDNDGSWRGY 
                 480 
               
               
                   
               
               
                 REQTCYAILA LVQARHVCFF THMVDRLQSC VDRGFSWLKS CSFHSQDLTW TSKTAYEVGF 
                 540 
               
               
                   
               
               
                 VAEAYKLAAL QSASLEVPAA TIGHSVTSAV PSSDLEKYMR LVRKTALFSP LDEWGLMASI 
                 600 
               
               
                   
               
               
                 IESSFFVPLL QAQRVEIYPR DNIKVDEDKY LSIIPFTWVG CNNRSRTFAS NRWLYDMMYL 
                 660 
               
               
                   
               
               
                 SLLGYQTDEY MEAVAGPVFG DVSLLHQTID KVIDNTMGNL ARANGTVHSG NGHQHESPNI 
                 720 
               
               
                   
               
               
                 GQVEDTLTRF TNSVLNHKDV LNSSSSDQDT LRREFRTFMH AHITQIEDNS RFSKQASSDA 
                 780 
               
               
                   
               
               
                 FSSPEQSYFQ WVNSTGGSHV ACAYSFAFSN CLMSANLLQG KDAFPSGTQK YLISSVMRHA 
                 840 
               
               
                   
               
               
                 TNMCRMYNDF GSIARDNAER NVNSIHFPEF TLCNGTSQNL DERKERLLKI ATYEQGYLDR 
                 900 
               
               
                   
               
               
                 ALEALERQSR DDAGDRAGSK DMRKLKIVKL FCDVTDLYDQ LYVIKDLSSS MK 
                 952 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 59 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggatgctg tgacgggttt gttaactgtc ccagcaaccg ctataactat tggtggaact 
                 60 
               
               
                   
               
               
                 gctgtagcat tggcggtagc gctaatcttt tggtacctga aatcctacac atcagctaga 
                 120 
               
               
                   
               
               
                 agatcccaat caaatcatct tccaagagtg cctgaagtcc caggtgttcc attgttagga 
                 180 
               
               
                   
               
               
                 aatctgttac aattgaagga gaaaaagcca tacatgactt ttacgagatg ggcagcgaca 
                 240 
               
               
                   
               
               
                 tatggaccta tctatagtat caaaactggg gctacaagta tggttgtggt atcatctaat 
                 300 
               
               
                   
               
               
                 gagatagcca aggaggcatt ggtgaccaga ttccaatcca tatctacaag gaacttatct 
                 360 
               
               
                   
               
               
                 aaagccctga aagtacttac agcagataag acaatggtcg caatgtcaga ttatgatgat 
                 420 
               
               
                   
               
               
                 tatcataaaa cagttaagag acacatactg accgccgtct tgggtcctaa tgcacagaaa 
                 480 
               
               
                   
               
               
                 aagcatagaa ttcacagaga tatcatgatg gataacatat ctactcaact tcatgaattc 
                 540 
               
               
                   
               
               
                 gtgaaaaaca acccagaaca ggaagaggta gaccttagaa aaatctttca atctgagtta 
                 600 
               
               
                   
               
               
                 ttcggcttag ctatgagaca agccttagga aaggatgttg aaagtttgta cgttgaagac 
                 660 
               
               
                   
               
               
                 ctgaaaatca ctatgaatag agacgaaatc tttcaagtcc ttgttgttga tccaatgatg 
                 720 
               
               
                   
               
               
                 ggagcaatcg atgttgattg gagagacttc tttccatacc taaagtgggt cccaaacaaa 
                 780 
               
               
                   
               
               
                 aagttcgaaa atactattca acaaatgtac atcagaagag aagctgttat gaaatcttta 
                 840 
               
               
                   
               
               
                 atcaaagagc acaaaaagag aatagcgtca ggcgaaaagc taaatagtta tatcgattac 
                 900 
               
               
                   
               
               
                 cttttatctg aagctcaaac tttaaccgat cagcaactat tgatgtcctt gtgggaacca 
                 960 
               
               
                   
               
               
                 atcattgaat cttcagatac aacaatggtc acaacagaat gggcaatgta cgaattagct 
                 1020 
               
               
                   
               
               
                 aaaaacccta aattgcaaga taggttgtac agagacatta agtccgtctg tggatctgaa 
                 1080 
               
               
                   
               
               
                 aagataaccg aagagcatct atcacagctg ccttacatta cagctatttt ccacgaaaca 
                 1140 
               
               
                   
               
               
                 ctgagaagac actcaccagt tcctatcatt cctctaagac atgtacatga agataccgtt 
                 1200 
               
               
                   
               
               
                 ctaggcggct accatgttcc tgctggcaca gaacttgccg ttaacatcta cggttgcaac 
                 1260 
               
               
                   
               
               
                 atggacaaaa acgtttggga aaatccagag gaatggaacc cagaaagatt catgaaagag 
                 1320 
               
               
                   
               
               
                 aatgagacaa ttgattttca aaagacgatg gccttcggtg gtggtaagag agtttgtgct 
                 1380 
               
               
                   
               
               
                 ggttccttgc aagccctttt aactgcatct attgggattg ggagaatggt tcaagagttc 
                 1440 
               
               
                   
               
               
                 gaatggaaac tgaaggatat gactcaagag gaagtgaaca cgataggcct aactacacaa 
                 1500 
               
               
                   
               
               
                 atgttaagac cattgagagc tattatcaaa cctaggatct aa 
                 1542 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 60 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MDAVTGLLTV PATAITIGGT AVALAVALIF WYLKSYTSAR RSQSNHLPRV PEVPGVPLLG 
                 60 
               
               
                   
               
               
                 NLLQLKEKKP YMTFTRWAAT YGPIYSIKTG ATSMVVVSSN EIAKEALVTR FQSISTRNLS 
                 120 
               
               
                   
               
               
                 KALKVLTADK TMVAMSDYDD YHKTVKRHIL TAVLGPNAQK KHRIHRDIMM DNISTQLHEF 
                 180 
               
               
                   
               
               
                 VKNNPEQEEV DLRKIFQSEL FGLAMRQALG KDVESLYVED LKITMNRDEI FQVLVVDPMM 
                 240 
               
               
                   
               
               
                 GAIDVDWRDF FPYLKWVPNK KFENTIQQMY IRREAVMKSL IKEHKKRIAS GEKLNSYIDY 
                 300 
               
               
                   
               
               
                 LLSEAQTLTD QQLLMSLWEP IIESSDTTMV TTEWAMYELA KNPKLQDRLY RDIKSVCGSE 
                 360 
               
               
                   
               
               
                 KITEEHLSQL PYITAIFHET LRRHSPVPII PLRHVHEDTV LGGYHVPAGT ELAVNIYGCN 
                 420 
               
               
                   
               
               
                 MDKNVWENPE EWNPERFMKE NETIDFQKTM AFGGGKRVCA GSLQALLTAS IGIGRMVQEF 
                 480 
               
               
                   
               
               
                 EWKLKDMTQE EVNTIGLTTQ MLRPLRAIIK PRI 
                 513 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 61 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 aagcttacta gtaaaatgga cggtgtcatc gatatgcaaa ccattccatt gagaaccgct 
                 60 
               
               
                   
               
               
                 attgctattg gtggtactgc tgttgctttg gttgttgcat tatacttttg gttcttgaga 
                 120 
               
               
                   
               
               
                 tcctacgctt ccccatctca tcattctaat catttgccac cagtacctga agttccaggt 
                 180 
               
               
                   
               
               
                 gttccagttt tgggtaattt gttgcaattg aaagaaaaaa agccttacat gaccttcacc 
                 240 
               
               
                   
               
               
                 aagtgggctg aaatgtatgg tccaatctac tctattagaa ctggtgctac ttccatggtt 
                 300 
               
               
                   
               
               
                 gttgtctctt ctaacgaaat cgccaaagaa gttgttgtta ccagattccc atctatctct 
                 360 
               
               
                   
               
               
                 accagaaaat tgtcttacgc cttgaaggtt ttgaccgaag ataagtctat ggttgccatg 
                 420 
               
               
                   
               
               
                 tctgattatc acgattacca taagaccgtc aagagacata ttttgactgc tgttttgggt 
                 480 
               
               
                   
               
               
                 ccaaacgccc aaaaaaagtt tagagcacat agagacacca tgatggaaaa cgtttccaat 
                 540 
               
               
                   
               
               
                 gaattgcatg ccttcttcga aaagaaccca aatcaagaag tcaacttgag aaagatcttc 
                 600 
               
               
                   
               
               
                 caatcccaat tattcggttt ggctatgaag caagccttgg gtaaagatgt tgaatccatc 
                 660 
               
               
                   
               
               
                 tacgttaagg atttggaaac caccatgaag agagaagaaa tcttcgaagt tttggttgtc 
                 720 
               
               
                   
               
               
                 gatccaatga tgggtgctat tgaagttgat tggagagact ttttcccata cttgaaatgg 
                 780 
               
               
                   
               
               
                 gttccaaaca agtccttcga aaacatcatc catagaatgt acactagaag agaagctgtt 
                 840 
               
               
                   
               
               
                 atgaaggcct tgatccaaga acacaagaaa agaattgcct ccggtgaaaa cttgaactcc 
                 900 
               
               
                   
               
               
                 tacattgatt acttgttgtc tgaagcccaa accttgaccg ataagcaatt attgatgtct 
                 960 
               
               
                   
               
               
                 ttgtgggaac ctattatcga atcttctgat accactatgg ttactactga atgggctatg 
                 1020 
               
               
                   
               
               
                 tacgaattgg ctaagaatcc aaacatgcaa gacagattat acgaagaaat ccaatccgtt 
                 1080 
               
               
                   
               
               
                 tgcggttccg aaaagattac tgaagaaaac ttgtcccaat tgccatactt gtacgctgtt 
                 1140 
               
               
                   
               
               
                 ttccaagaaa ctttgagaaa gcactgtcca gttcctatta tgccattgag atatgttcac 
                 1200 
               
               
                   
               
               
                 gaaaacaccg ttttgggtgg ttatcatgtt ccagctggta ctgaagttgc tattaacatc 
                 1260 
               
               
                   
               
               
                 tacggttgca acatggataa gaaggtctgg gaaaatccag aagaatggaa tccagaaaga 
                 1320 
               
               
                   
               
               
                 ttcttgtccg aaaaagaatc catggacttg tacaaaacta tggcttttgg tggtggtaaa 
                 1380 
               
               
                   
               
               
                 agagtttgcg ctggttcttt acaagccatg gttatttctt gcattggtat cggtagattg 
                 1440 
               
               
                   
               
               
                 gtccaagatt ttgaatggaa gttgaaggat gatgccgaag aagatgttaa cactttgggt 
                 1500 
               
               
                   
               
               
                 ttgactaccc aaaagttgca tccattattg gccttgatta acccaagaaa gtaactcgag 
                 1560 
               
               
                   
               
               
                 ccgcgg 
                 1566 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 62 
               
               
                 
                   L. sativa 
                 
               
            
           
           
               
               
            
               
                 MDGVIDMQTI PLRTAIAIGG TAVALVVALY FWFLRSYASP SHHSNHLPPV PEVPGVPVLG 
                 60 
               
               
                   
               
               
                 NLLQLKEKKP YMTFTKWAEM YGPIYSIRTG ATSMVVVSSN EIAKEVVVTR FPSISTRKLS 
                 120 
               
               
                   
               
               
                 YALKVLTEDK SMVAMSDYHD YHKTVKRHIL TAVLGPNAQK KFRAHRDTMM ENVSNELHAF 
                 180 
               
               
                   
               
               
                 FEKNPNQEVN LRKIFQSQLF GLAMKQALGK DVESIYVKDL ETTMKREEIF EVLVVDPMMG 
                 240 
               
               
                   
               
               
                 AIEVDWRDFF PYLKWVPNKS FENIIHRMYT RREAVMKALI QEHKKRIASG ENLNSYIDYL 
                 300 
               
               
                   
               
               
                 LSEAQTLTDK QLLMSLWEPI IESSDTTMVT TEWAMYELAK NPNMQDRLYE EIQSVCGSEK 
                 360 
               
               
                   
               
               
                 ITEENLSQLP YLYAVFQETL RKHCPVPIMP LRYVHENTVL GGYHVPAGTE VAINIYGCNM 
                 420 
               
               
                   
               
               
                 DKKVWENPEE WNPERFLSEK ESMDLYKTMA FGGGKRVCAG SLQAMVISCI GIGRLVQDFE 
                 480 
               
               
                   
               
               
                 WKLKDDAEED VNTLGLTTQK LHPLLALINP RK 
                 512 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 63 
               
               
                 
                   R. suavissimus 
                 
               
            
           
           
               
               
            
               
                 atggccaccc tccttgagca tttccaagct atgccctttg ccatccctat tgcactggct 
                 60 
               
               
                   
               
               
                 gctctgtctt ggctgttcct cttttacatc aaagtttcat tcttttccaa caagagtgct 
                 120 
               
               
                   
               
               
                 caggctaagc tccctcctgt gccagtggtt cctgggctgc cggtgattgg gaatttactg 
                 180 
               
               
                   
               
               
                 caactcaagg agaagaaacc ctaccagact tttacaaggt gggctgagga gtatggacca 
                 240 
               
               
                   
               
               
                 atctattcta tcaggactgg tgcttccacc atggtcgttc tcaataccac ccaagttgca 
                 300 
               
               
                   
               
               
                 aaagaggcca tggtgaccag atatttatcc atctcaacca gaaagctatc aaacgcacta 
                 360 
               
               
                   
               
               
                 aagattctta ctgctgataa atgtatggtt gcaataagtg actacaacga ttttcacaag 
                 420 
               
               
                   
               
               
                 atgataaagc gatacatact ctcaaatgtt cttggaccta gtgctcagaa gcgtcaccgg 
                 480 
               
               
                   
               
               
                 agcaacagag ataccttgag agctaatgtc tgcagccgat tgcattctca agtaaagaac 
                 540 
               
               
                   
               
               
                 tctcctcgag aagctgtgaa tttcagaaga gtttttgagt gggaactctt tggaattgca 
                 600 
               
               
                   
               
               
                 ttgaagcaag cctttggaaa ggacatagaa aagcccattt atgtggagga acttggcact 
                 660 
               
               
                   
               
               
                 acactgtcaa gagatgagat ctttaaggtt ctagtgcttg acataatgga gggtgcaatt 
                 720 
               
               
                   
               
               
                 gaggttgatt ggagagattt cttcccttac ctgagatgga ttccgaatac gcgcatggaa 
                 780 
               
               
                   
               
               
                 acaaaaattc agcgactcta tttccgcagg aaagcagtga tgactgccct gatcaacgag 
                 840 
               
               
                   
               
               
                 cagaagaagc gaattgcttc aggagaggaa atcaactgtt atatcgactt cttgcttaag 
                 900 
               
               
                   
               
               
                 gaagggaaga cactgacaat ggaccaaata agtatgttgc tttgggagac ggttattgaa 
                 960 
               
               
                   
               
               
                 acagcagata ctacaatggt aacgacagaa tgggctatgt atgaagttgc taaagactca 
                 1020 
               
               
                   
               
               
                 aagcgtcagg atcgtctcta tcaggaaatc caaaaggttt gtggatcgga gatggttaca 
                 1080 
               
               
                   
               
               
                 gaggaatact tgtcccaact gccgtacctg aatgcagttt tccatgaaac gctaaggaag 
                 1140 
               
               
                   
               
               
                 cacagtccgg ctgcgttagt tcctttaaga tatgcacatg aagataccca actaggaggt 
                 1200 
               
               
                   
               
               
                 tactacattc cagctggaac tgagattgct ataaacatat acgggtgtaa catggacaag 
                 1260 
               
               
                   
               
               
                 catcaatggg aaagccctga ggaatggaaa ccggagagat ttttggaccc gaaatttgat 
                 1320 
               
               
                   
               
               
                 cctatggatt tgtacaagac catggctttt ggggctggaa agagggtatg tgctggttct 
                 1380 
               
               
                   
               
               
                 cttcaggcaa tgttaatagc gtgcccgacg attggtaggc tggtgcagga gtttgagtgg 
                 1440 
               
               
                   
               
               
                 aagctgagag atggagaaga agaaaatgta gatactgttg ggctcaccac tcacaaacgc 
                 1500 
               
               
                   
               
               
                 tatccaatgc atgcaatcct gaagccaaga agtta 
                 1535 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 64 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggctacct tgttggaaca ttttcaagct atgccattcg ctattccaat tgctttggct 
                 60 
               
               
                   
               
               
                 gctttgtctt ggttgttttt gttctacatc aaggtttctt tcttctccaa caaatccgct 
                 120 
               
               
                   
               
               
                 caagctaaat tgccaccagt tccagttgtt ccaggtttgc cagttattgg taatttgttg 
                 180 
               
               
                   
               
               
                 caattgaaag aaaagaagcc ataccaaacc ttcactagat gggctgaaga atatggtcca 
                 240 
               
               
                   
               
               
                 atctactcta ttagaactgg tgcttctact atggttgtct tgaacactac tcaagttgcc 
                 300 
               
               
                   
               
               
                 aaagaagcta tggttaccag atacttgtct atctctacca gaaagttgtc caacgccttg 
                 360 
               
               
                   
               
               
                 aaaattttga ccgctgataa gtgcatggtt gccatttctg attacaacga tttccacaag 
                 420 
               
               
                   
               
               
                 atgatcaaga gatatatctt gtctaacgtt ttgggtccat ctgcccaaaa aagacataga 
                 480 
               
               
                   
               
               
                 tctaacagag ataccttgag agccaacgtt tgttctagat tgcattccca agttaagaac 
                 540 
               
               
                   
               
               
                 tctccaagag aagctgtcaa ctttagaaga gttttcgaat gggaattatt cggtatcgct 
                 600 
               
               
                   
               
               
                 ttgaaacaag ccttcggtaa ggatattgaa aagccaatct acgtcgaaga attgggtact 
                 660 
               
               
                   
               
               
                 actttgtcca gagatgaaat cttcaaggtt ttggtcttgg acattatgga aggtgccatt 
                 720 
               
               
                   
               
               
                 gaagttgatt ggagagattt tttcccatac ttgcgttgga ttccaaacac cagaatggaa 
                 780 
               
               
                   
               
               
                 actaagatcc aaagattata ctttagaaga aaggccgtta tgaccgcctt gattaacgaa 
                 840 
               
               
                   
               
               
                 caaaagaaaa gaattgcctc cggtgaagaa atcaactgct acatcgattt cttgttgaaa 
                 900 
               
               
                   
               
               
                 gaaggtaaga ccttgaccat ggaccaaatc tctatgttgt tgtgggaaac cgttattgaa 
                 960 
               
               
                   
               
               
                 actgctgata ccacaatggt tactactgaa tgggctatgt acgaagttgc taaggattct 
                 1020 
               
               
                   
               
               
                 aaaagacaag acagattata ccaagaaatc caaaaggtct gcggttctga aatggttaca 
                 1080 
               
               
                   
               
               
                 gaagaatact tgtcccaatt gccatacttg aatgctgttt tccacgaaac tttgagaaaa 
                 1140 
               
               
                   
               
               
                 cattctccag ctgctttggt tccattgaga tatgctcatg aagatactca attgggtggt 
                 1200 
               
               
                   
               
               
                 tattacattc cagccggtac tgaaattgcc attaacatct acggttgcaa catggacaaa 
                 1260 
               
               
                   
               
               
                 caccaatggg aatctccaga agaatggaag ccagaaagat ttttggatcc taagtttgac 
                 1320 
               
               
                   
               
               
                 ccaatggact tgtacaaaac tatggctttt ggtgctggta aaagagtttg cgctggttct 
                 1380 
               
               
                   
               
               
                 ttacaagcta tgttgattgc ttgtccaacc atcggtagat tggttcaaga atttgaatgg 
                 1440 
               
               
                   
               
               
                 aagttgagag atggtgaaga agaaaacgtt gatactgttg gtttgaccac ccataagaga 
                 1500 
               
               
                   
               
               
                 tatccaatgc atgctatttt gaagccaaga tcttaa 
                 1536 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 65 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 aagcttacta gtaaaatggc ctccatcacc catttcttac aagattttca agctactcca 
                 60 
               
               
                   
               
               
                 ttcgctactg cttttgctgt tggtggtgtt tctttgttga tattcttctt cttcatccgt 
                 120 
               
               
                   
               
               
                 ggtttccact ctactaagaa aaacgaatat tacaagttgc caccagttcc agttgttcca 
                 180 
               
               
                   
               
               
                 ggtttgccag ttgttggtaa tttgttgcaa ttgaaagaaa agaagccata caagactttc 
                 240 
               
               
                   
               
               
                 ttgagatggg ctgaaattca tggtccaatc tactctatta gaactggtgc ttctaccatg 
                 300 
               
               
                   
               
               
                 gttgttgtta actctactca tgttgccaaa gaagctatgg ttaccagatt ctcttcaatc 
                 360 
               
               
                   
               
               
                 tctaccagaa agttgtccaa ggctttggaa ttattgacct ccaacaaatc tatggttgcc 
                 420 
               
               
                   
               
               
                 acctctgatt acaacgaatt tcacaagatg gtcaagaagt acatcttggc cgaattattg 
                 480 
               
               
                   
               
               
                 ggtgctaatg ctcaaaagag acacagaatt catagagaca ccttgatcga aaacgtcttg 
                 540 
               
               
                   
               
               
                 aacaaattgc atgcccatac caagaattct ccattgcaag ctgttaactt cagaaagatc 
                 600 
               
               
                   
               
               
                 ttcgaatctg aattattcgg tttggctatg aagcaagcct tgggttatga tgttgattcc 
                 660 
               
               
                   
               
               
                 ttgttcgttg aagaattggg tactaccttg tccagagaag aaatctacaa cgttttggtc 
                 720 
               
               
                   
               
               
                 agtgacatgt tgaagggtgc tattgaagtt gattggagag actttttccc atacttgaaa 
                 780 
               
               
                   
               
               
                 tggatcccaa acaagtcctt cgaaatgaag attcaaagat tggcctctag aagacaagcc 
                 840 
               
               
                   
               
               
                 gttatgaact ctattgtcaa agaacaaaag aagtccattg cctctggtaa gggtgaaaac 
                 900 
               
               
                   
               
               
                 tgttacttga attacttgtt gtccgaagct aagactttga ccgaaaagca aatttccatt 
                 960 
               
               
                   
               
               
                 ttggcctggg aaaccattat tgaaactgct gatacaactg ttgttaccac tgaatgggct 
                 1020 
               
               
                   
               
               
                 atgtacgaat tggctaaaaa cccaaagcaa caagacagat tatacaacga aatccaaaac 
                 1080 
               
               
                   
               
               
                 gtctgcggta ctgataagat taccgaagaa catttgtcca agttgcctta cttgtctgct 
                 1140 
               
               
                   
               
               
                 gtttttcacg aaaccttgag aaagtattct ccatctccat tggttccatt gagatacgct 
                 1200 
               
               
                   
               
               
                 catgaagata ctcaattggg tggttattat gttccagccg gtactgaaat tgctgttaat 
                 1260 
               
               
                   
               
               
                 atctacggtt gcaacatgga caagaatcaa tgggaaactc cagaagaatg gaagccagaa 
                 1320 
               
               
                   
               
               
                 agatttttgg acgaaaagta cgatccaatg gacatgtaca agactatgtc ttttggttcc 
                 1380 
               
               
                   
               
               
                 ggtaaaagag tttgcgctgg ttctttacaa gctagtttga ttgcttgtac ctccatcggt 
                 1440 
               
               
                   
               
               
                 agattggttc aagaatttga atggagattg aaagacggtg aagttgaaaa cgttgatacc 
                 1500 
               
               
                   
               
               
                 ttgggtttga ctacccataa gttgtatcca atgcaagcta tcttgcaacc tagaaactga 
                 1560 
               
               
                   
               
               
                 ctcgagccgc gg 
                 1572 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 66 
               
               
                 
                   C. mollissima 
                 
               
            
           
           
               
               
            
               
                 MASITHFLQD FQATPFATAF AVGGVSLLIF FFFIRGFHST KKNEYYKLPP VPVVPGLPVV 
                 60 
               
               
                   
               
               
                 GNLLQLKEKK PYKTFLRWAE IHGPIYSIRT GASTMVVVNS THVAKEAMVT RFSSISTRKL 
                 120 
               
               
                   
               
               
                 SKALELLTSN KSMVATSDYN EFHKMVKKYI LAELLGANAQ KRHRIHRDTL IENVLNKLHA 
                 180 
               
               
                   
               
               
                 HTKNSPLQAV NFRKIFESEL FGLAMKQALG YDVDSLFVEE LGTTLSREEI YNVLVSDMLK 
                 240 
               
               
                   
               
               
                 GAIEVDWRDF FPYLKWIPNK SFEMKIQRLA SRRQAVMNSI VKEQKKSIAS GKGENCYLNY 
                 300 
               
               
                   
               
               
                 LLSEAKTLTE KQISILAWET IIETADTTVV TTEWAMYELA KNPKQQDRLY NEIQNVCGTD 
                 360 
               
               
                   
               
               
                 KITEEHLSKL PYLSAVFHET LRKYSPSPLV PLRYAHEDTQ LGGYYVPAGT EIAVNIYGCN 
                 420 
               
               
                   
               
               
                 MDKNQWETPE EWKPERFLDE KYDPMDMYKT MSFGSGKRVC AGSLQASLIA CTSIGRLVQE 
                 480 
               
               
                   
               
               
                 FEWRLKDGEV ENVDTLGLTT HKLYPMQAIL QPRN 
                 514 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 67 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgatttcct tgttgttggg ttttgttgtc tcctccttct tgtttatctt cttcttgaaa 
                 60 
               
               
                   
               
               
                 aaattgttgt tcttcttcag tcgtcacaaa atgtccgaag tttctagatt gccatctgtt 
                 120 
               
               
                   
               
               
                 ccagttccag gttttccatt gattggtaac ttgttgcaat tgaaagaaaa gaagccacac 
                 180 
               
               
                   
               
               
                 aagactttca ccaagtggtc tgaattatat ggtccaatct actctatcaa gatgggttcc 
                 240 
               
               
                   
               
               
                 tcttctttga tcgtcttgaa ctctattgaa accgccaaag aagctatggt cagtagattc 
                 300 
               
               
                   
               
               
                 tcttcaatct ctaccagaaa gttgtctaac gctttgactg ttttgacctg caacaaatct 
                 360 
               
               
                   
               
               
                 atggttgcta cctctgatta cgatgacttt cataagttcg tcaagagatg cttgttgaac 
                 420 
               
               
                   
               
               
                 ggtttgttgg gtgctaatgc tcaagaaaga aaaagacatt acagagatgc cttgatcgaa 
                 480 
               
               
                   
               
               
                 aacgttacct ctaaattgca tgcccatacc agaaatcatc cacaagaacc agttaacttc 
                 540 
               
               
                   
               
               
                 agagccattt tcgaacacga attattcggt gttgctttga aacaagcctt cggtaaagat 
                 600 
               
               
                   
               
               
                 gtcgaatcca tctatgtaaa agaattgggt gtcaccttgt ccagagatga aattttcaag 
                 660 
               
               
                   
               
               
                 gttttggtcc acgacatgat ggaaggtgct attgatgttg attggagaga tttcttccca 
                 720 
               
               
                   
               
               
                 tacttgaaat ggatcccaaa caactctttc gaagccagaa ttcaacaaaa gcacaagaga 
                 780 
               
               
                   
               
               
                 agattggctg ttatgaacgc cttgatccaa gacagattga atcaaaacga ttccgaatcc 
                 840 
               
               
                   
               
               
                 gatgatgact gctacttgaa tttcttgatg tctgaagcta agaccttgac catggaacaa 
                 900 
               
               
                   
               
               
                 attgctattt tggtttggga aaccattatc gaaactgctg ataccacttt ggttactact 
                 960 
               
               
                   
               
               
                 gaatgggcta tgtacgaatt ggccaaacat caatctgttc aagatagatt attcaaagaa 
                 1020 
               
               
                   
               
               
                 atccaatccg tctgcggtgg tgaaaagatc aaagaagaac aattgccaag attgccttac 
                 1080 
               
               
                   
               
               
                 gtcaatggtg tttttcacga aaccttgaga aagtattctc cagctccatt ggttccaatt 
                 1140 
               
               
                   
               
               
                 agatacgctc atgaagatac ccaaattggt ggttatcata ttccagccgg ttctgaaatt 
                 1200 
               
               
                   
               
               
                 gccattaaca tctacggttg caacatggat aagaagagat gggaaagacc tgaagaatgg 
                 1260 
               
               
                   
               
               
                 tggccagaaa gatttttgga agatagatac gaatcctccg acttgcataa gactatggct 
                 1320 
               
               
                   
               
               
                 tttggtgctg gtaaaagagt ttgtgctggt gctttacaag ctagtttgat ggctggtatt 
                 1380 
               
               
                   
               
               
                 gctatcggta gattggttca agaattcgaa tggaagttga gagatggtga agaagaaaac 
                 1440 
               
               
                   
               
               
                 gttgatactt acggtttgac ctcccaaaag ttgtatccat tgatggccat tatcaaccca 
                 1500 
               
               
                   
               
               
                 agaagatctt aa 
                 1512 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 68 
               
               
                 
                   T. halophila 
                 
               
            
           
           
               
               
            
               
                 MASMISLLLG FVVSSFLFIF FLKKLLFFFS RHKMSEVSRL PSVPVPGFPL IGNLLQLKEK 
                 60 
               
               
                   
               
               
                 KPHKTFTKWS ELYGPIYSIK MGSSSLIVLN SIETAKEAMV SRFSSISTRK LSNALTVLTC 
                 120 
               
               
                   
               
               
                 NKSMVATSDY DDFHKFVKRC LLNGLLGANA QERKRHYRDA LIENVTSKLH AHTRNHPQEP 
                 180 
               
               
                   
               
               
                 VNFRAIFEHE LFGVALKQAF GKDVESIYVK ELGVTLSRDE IFKVLVHDMM EGAIDVDWRD 
                 240 
               
               
                   
               
               
                 FFPYLKWIPN NSFEARIQQK HKRRLAVMNA LIQDRLNQND SESDDDCYLN FLMSEAKTLT 
                 300 
               
               
                   
               
               
                 MEQIAILVWE TIIETADTTL VTTEWAMYEL AKHQSVQDRL FKEIQSVCGG EKIKEEQLPR 
                 360 
               
               
                   
               
               
                 LPYVNGVFHE TLRKYSPAPL VPIRYAHEDT QIGGYHIPAG SEIAINIYGC NMDKKRWERP 
                 420 
               
               
                   
               
               
                 EEWWPERFLE DRYESSDLHK TMAFGAGKRV CAGALQASLM AGIAIGRLVQ EFEWKLRDGE 
                 480 
               
               
                   
               
               
                 EENVDTYGLT SQKLYPLMAI INPRRS 
                 506 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 69 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 aagcttacta gtaaaatgga catgatgggt attgaagctg ttccatttgc tactgctgtt 
                 60 
               
               
                   
               
               
                 gttttgggtg gtatttcctt ggttgttttg atcttcatca gaagattcgt ttccaacaga 
                 120 
               
               
                   
               
               
                 aagagatccg ttgaaggttt gccaccagtt ccagatattc caggtttacc attgattggt 
                 180 
               
               
                   
               
               
                 aacttgttgc aattgaaaga aaagaagcca cataagacct ttgctagatg ggctgaaact 
                 240 
               
               
                   
               
               
                 tacggtccaa ttttctctat tagaactggt gcttctacca tgatcgtctt gaattcttct 
                 300 
               
               
                   
               
               
                 gaagttgcca aagaagctat ggtcactaga ttctcttcaa tctctaccag aaagttgtcc 
                 360 
               
               
                   
               
               
                 aacgccttga agattttgac cttcgataag tgtatggttg ccacctctga ttacaacgat 
                 420 
               
               
                   
               
               
                 tttcacaaaa tggtcaaggg tttcatcttg agaaacgttt taggtgctcc agcccaaaaa 
                 480 
               
               
                   
               
               
                 agacatagat gtcatagaga taccttgatc gaaaacatct ctaagtactt gcatgcccat 
                 540 
               
               
                   
               
               
                 gttaagactt ctccattgga accagttgtc ttgaagaaga ttttcgaatc cgaaattttc 
                 600 
               
               
                   
               
               
                 ggtttggctt tgaaacaagc cttgggtaag gatatcgaat ccatctatgt tgaagaattg 
                 660 
               
               
                   
               
               
                 ggtactacct tgtccagaga agaaattttt gccgttttgg ttgttgatcc aatggctggt 
                 720 
               
               
                   
               
               
                 gctattgaag ttgattggag agattttttc ccatacttgt cctggattcc aaacaagtct 
                 780 
               
               
                   
               
               
                 atggaaatga agatccaaag aatggatttt agaagaggtg ctttgatgaa ggccttgatt 
                 840 
               
               
                   
               
               
                 ggtgaacaaa agaaaagaat cggttccggt gaagaaaaga actcctacat tgatttcttg 
                 900 
               
               
                   
               
               
                 ttgtctgaag ctaccacttt gaccgaaaag caaattgcta tgttgatctg ggaaaccatc 
                 960 
               
               
                   
               
               
                 atcgaaattt ccgatacaac tttggttacc tctgaatggg ctatgtacga attggctaaa 
                 1020 
               
               
                   
               
               
                 gacccaaata gacaagaaat cttgtacaga gaaatccaca aggtttgcgg ttctaacaag 
                 1080 
               
               
                   
               
               
                 ttgactgaag aaaacttgtc caagttgcca tacttgaact ctgttttcca cgaaaccttg 
                 1140 
               
               
                   
               
               
                 agaaagtatt ctccagctcc aatggttcca gttagatatg ctcatgaaga tactcaattg 
                 1200 
               
               
                   
               
               
                 ggtggttacc atattccagc tggttctcaa attgccatta acatctacgg ttgcaacatg 
                 1260 
               
               
                   
               
               
                 aacaaaaagc aatgggaaaa tcctgaagaa tggaagccag aaagattctt ggacgaaaag 
                 1320 
               
               
                   
               
               
                 tatgacttga tggacttgca taagactatg gcttttggtg gtggtaaaag agtttgtgct 
                 1380 
               
               
                   
               
               
                 ggtgctttac aagcaatgtt gattgcttgc acttccatcg gtagattcgt tcaagaattt 
                 1440 
               
               
                   
               
               
                 gaatggaagt tgatgggtgg tgaagaagaa aacgttgata ctgttgcttt gacctcccaa 
                 1500 
               
               
                   
               
               
                 aaattgcatc caatgcaagc cattattaag gccagagaat gactcgagcc gcgg 
                 1554 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 70 
               
               
                 
                   V. vinifera 
                 
               
            
           
           
               
               
            
               
                 MDMMGIEAVP FATAVVLGGI SLVVLIFIRR FVSNRKRSVE GLPPVPDIPG LPLIGNLLQL 
                 60 
               
               
                   
               
               
                 KEKKPHKTFA RWAETYGPIF SIRTGASTMI VLNSSEVAKE AMVTRFSSIS TRKLSNALKI 
                 120 
               
               
                   
               
               
                 LTFDKCMVAT SDYNDFHKMV KGFILRNVLG APAQKRHRCH RDTLIENISK YLHAHVKTSP 
                 180 
               
               
                   
               
               
                 LEPVVLKKIF ESEIFGLALK QALGKDIESI YVEELGTTLS REEIFAVLVV DPMAGAIEVD 
                 240 
               
               
                   
               
               
                 WRDFFPYLSW IPNKSMEMKI QRMDFRRGAL MKALIGEQKK RIGSGEEKNS YIDFLLSEAT 
                 300 
               
               
                   
               
               
                 TLTEKQIAML IWETIIEISD TTLVTSEWAM YELAKDPNRQ EILYREIHKV CGSNKLTEEN 
                 360 
               
               
                   
               
               
                 LSKLPYLNSV FHETLRKYSP APMVPVRYAH EDTQLGGYHI PAGSQIAINI YGCNMNKKQW 
                 420 
               
               
                   
               
               
                 ENPEEWKPER FLDEKYDLMD LHKTMAFGGG KRVCAGALQA MLIACTSIGR FVQEFEWKLM 
                 480 
               
               
                   
               
               
                 GGEEENVDTV ALTSQKLHPM QAIIKARE 
                 508 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 71 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 aagcttaaaa tgagtaagtc taatagtatg aattctacat cacacgaaac cctttttcaa 
                 60 
               
               
                   
               
               
                 caattggtct tgggtttgga ccgtatgcca ttgatggatg ttcactggtt gatctacgtt 
                 120 
               
               
                   
               
               
                 gctttcggcg catggttatg ttcttatgtg atacatgttt tatcatcttc ctctacagta 
                 180 
               
               
                   
               
               
                 aaagtgccag ttgttggata caggtctgta ttcgaaccta catggttgct tagacttaga 
                 240 
               
               
                   
               
               
                 ttcgtctggg aaggtggctc tatcataggt caagggtaca ataagtttaa agactctatt 
                 300 
               
               
                   
               
               
                 ttccaagtta ggaaattggg aactgatatt gtcattatac cacctaacta tattgatgaa 
                 360 
               
               
                   
               
               
                 gtgagaaaat tgtcacagga caagactaga tcagttgaac ctttcattaa tgattttgca 
                 420 
               
               
                   
               
               
                 ggtcaataca caagaggcat ggttttcttg caatctgact tacaaaaccg tgttatacaa 
                 480 
               
               
                   
               
               
                 caaagactaa ctccaaaatt ggtttccttg accaaggtca tgaaggaaga gttggattat 
                 540 
               
               
                   
               
               
                 gctttaacaa aagagatgcc tgatatgaaa aatgacgaat gggtagaagt agatatcagt 
                 600 
               
               
                   
               
               
                 agtataatgg tgagattgat ttccaggatc tccgccagag tctttctagg gcctgaacac 
                 660 
               
               
                   
               
               
                 tgtcgtaacc aggaatggtt gactactaca gcagaatatt cagaatcact tttcattaca 
                 720 
               
               
                   
               
               
                 gggtttatct taagagttgt acctcatatc ttaagaccat tcatcgcccc tctattacct 
                 780 
               
               
                   
               
               
                 tcatacagga ctctacttag aaacgtttca agtggtagaa gagtcatcgg tgacatcata 
                 840 
               
               
                   
               
               
                 agatctcagc aaggggatgg taacgaagat atactttcct ggatgagaga tgctgccaca 
                 900 
               
               
                   
               
               
                 ggagaggaaa agcaaatcga taacattgct cagagaatgt taattctttc tttagcatca 
                 960 
               
               
                   
               
               
                 atccacacta ctgcgatgac catgacacat gccatgtacg atctatgtgc ttgccctgag 
                 1020 
               
               
                   
               
               
                 tacattgaac cattaagaga tgaagttaaa tctgttgttg gggcttctgg ctgggacaag 
                 1080 
               
               
                   
               
               
                 acagcgttaa acagatttca taagttggac tccttcctaa aagagtcaca aagattcaac 
                 1140 
               
               
                   
               
               
                 ccagtattct tattgacatt caatagaatc taccatcaat ctatgacctt atcagatggc 
                 1200 
               
               
                   
               
               
                 actaacattc catctggaac acgtattgct gttccatcac acgcaatgtt gcaagattct 
                 1260 
               
               
                   
               
               
                 gcacatgtcc caggtccaac cccacctact gaatttgatg gattcagata tagtaagata 
                 1320 
               
               
                   
               
               
                 cgttctgata gtaactacgc acaaaagtac ctattctcca tgaccgattc ttcaaacatg 
                 1380 
               
               
                   
               
               
                 gctttcggat acggcaagta tgcttgtcca ggtagatttt acgcgtctaa tgagatgaaa 
                 1440 
               
               
                   
               
               
                 ctaacattag ccattttgtt gctacaattt gagttcaaac taccagatgg taaaggtcgt 
                 1500 
               
               
                   
               
               
                 cctagaaata tcactatcga ttctgatatg attccagacc caagagctag actttgcgtc 
                 1560 
               
               
                   
               
               
                 agaaaaagat cacttagaga tgaatgaccg cgg 
                 1593 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 72 
               
               
                 
                   G. fujikuroi 
                 
               
            
           
           
               
               
            
               
                 MSKSNSMNST SHETLFQQLV LGLDRMPLMD VHWLIYVAFG AWLCSYVIHV LSSSSTVKVP 
                 60 
               
               
                   
               
               
                 VVGYRSVFEP TWLLRLRFVW EGGSIIGQGY NKFKDSIFQV RKLGTDIVII PPNYIDEVRK 
                 120 
               
               
                   
               
               
                 LSQDKTRSVE PFINDFAGQY TRGMVFLQSD LQNRVIQQRL TPKLVSLTKV MKEELDYALT 
                 180 
               
               
                   
               
               
                 KEMPDMKNDE WVEVDISSIM VRLISRISAR VFLGPEHCRN QEWLTTTAEY SESLFITGFI 
                 240 
               
               
                   
               
               
                 LRVVPHILRP FIAPLLPSYR TLLRNVSSGR RVIGDIIRSQ QGDGNEDILS WMRDAATGEE 
                 300 
               
               
                   
               
               
                 KQIDNIAQRM LILSLASIHT TAMTMTHAMY DLCACPEYIE PLRDEVKSVV GASGWDKTAL 
                 360 
               
               
                   
               
               
                 NRFHKLDSFL KESQRFNPVF LLTFNRIYHQ SMTLSDGTNI PSGTRIAVPS HAMLQDSAHV 
                 420 
               
               
                   
               
               
                 PGPTPPTEFD GFRYSKIRSD SNYAQKYLFS MTDSSNMAFG YGKYACPGRF YASNEMKLTL 
                 480 
               
               
                   
               
               
                 AILLLQFEFK LPDGKGRPRN ITIDSDMIPD PRARLCVRKR SLRDE 
                 525 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 73 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 aagcttaaaa tggaagatcc tactgtctta tatgcttgtc ttgccattgc agttgcaact 
                 60 
               
               
                   
               
               
                 ttcgttgtta gatggtacag agatccattg agatccatcc caacagttgg tggttccgat 
                 120 
               
               
                   
               
               
                 ttgcctattc tatcttacat cggcgcacta agatggacaa gacgtggcag agagatactt 
                 180 
               
               
                   
               
               
                 caagagggat atgatggcta cagaggatct acattcaaaa tcgcgatgtt agaccgttgg 
                 240 
               
               
                   
               
               
                 atcgtgatcg caaatggtcc taaactagct gatgaagtca gacgtagacc agatgaagag 
                 300 
               
               
                   
               
               
                 ttaaacttta tggacggatt aggagcattc gtccaaacta agtacacctt aggtgaagct 
                 360 
               
               
                   
               
               
                 attcataacg atccatacca tgtcgatatc ataagagaaa aactaacaag aggccttcca 
                 420 
               
               
                   
               
               
                 gccgtgcttc ctgatgtcat tgaagagttg acacttgcgg ttagacagta cattccaaca 
                 480 
               
               
                   
               
               
                 gaaggtgatg aatgggtgtc cgtaaactgt tcaaaggccg caagagatat tgttgctaga 
                 540 
               
               
                   
               
               
                 gcttctaata gagtctttgt aggtttgcct gcttgcagaa accaaggtta cttagatttg 
                 600 
               
               
                   
               
               
                 gcaatagact ttacattgtc tgttgtcaag gatagagcca tcatcaatat gtttccagaa 
                 660 
               
               
                   
               
               
                 ttgttgaagc caatagttgg cagagttgta ggtaacgcca ccagaaatgt tcgtagagct 
                 720 
               
               
                   
               
               
                 gttccttttg ttgctccatt ggtggaggaa agacgtagac ttatggaaga gtacggtgaa 
                 780 
               
               
                   
               
               
                 gactggtctg aaaaacctaa tgatatgtta cagtggataa tggatgaagc tgcatccaga 
                 840 
               
               
                   
               
               
                 gatagttcag tgaaggcaat cgcagagaga ttgttaatgg tgaacttcgc ggctattcat 
                 900 
               
               
                   
               
               
                 acctcatcaa acactatcac tcatgctttg taccaccttg ccgaaatgcc tgaaactttg 
                 960 
               
               
                   
               
               
                 caaccactta gagaagagat cgaaccatta gtcaaagagg agggctggac caaggctgct 
                 1020 
               
               
                   
               
               
                 atgggaaaaa tgtggtggtt agattcattt ctaagagaat ctcaaagata caatggcatt 
                 1080 
               
               
                   
               
               
                 aacatcgtat ctttaactag aatggctgac aaagatatta cattgagtga tggcacattt 
                 1140 
               
               
                   
               
               
                 ttgccaaaag gtactctagt ggccgttcca gcgtattcta ctcatagaga tgatgctgtc 
                 1200 
               
               
                   
               
               
                 tacgctgatg ccttagtatt cgatcctttc agattctcac gtatgagagc gagagaaggt 
                 1260 
               
               
                   
               
               
                 gaaggtacaa agcaccagtt cgttaatact tcagtcgagt acgttccatt tggtcacgga 
                 1320 
               
               
                   
               
               
                 aagcatgctt gtccaggaag attcttcgcc gcaaacgaat tgaaagcaat gttggcttac 
                 1380 
               
               
                   
               
               
                 attgttctaa actatgatgt aaagttgcct ggtgacggta aacgtccatt gaacatgtat 
                 1440 
               
               
                   
               
               
                 tggggtccaa cagttttgcc tgcaccagca ggccaagtat tgttcagaaa gagacaagtt 
                 1500 
               
               
                   
               
               
                 agtctataac cgcgg 
                 1515 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 74 
               
               
                 
                   T. versicolor 
                 
               
            
           
           
               
               
            
               
                 MEDPTVLYAC LAIAVATFVV RWYRDPLRSI PTVGGSDLPI LSYIGALRWT RRGREILQEG 
                 60 
               
               
                   
               
               
                 YDGYRGSTFK IAMLDRWIVI ANGPKLADEV RRRPDEELNF MDGLGAFVQT KYTLGEAIHN 
                 120 
               
               
                   
               
               
                 DPYHVDIIRE KLTRGLPAVL PDVIEELTLA VRQYIPTEGD EWVSVNCSKA ARDIVARASN 
                 180 
               
               
                   
               
               
                 RVFVGLPACR NQGYLDLAID FTLSVVKDRA IINMFPELLK PIVGRVVGNA TRNVRRAVPF 
                 240 
               
               
                   
               
               
                 VAPLVEERRR LMEEYGEDWS EKPNDMLQWI MDEAASRDSS VKAIAERLLM VNFAAIHTSS 
                 300 
               
               
                   
               
               
                 NTITHALYHL AEMPETLQPL REEIEPLVKE EGWTKAAMGK MWWLDSFLRE SQRYNGINIV 
                 360 
               
               
                   
               
               
                 SLTRMADKDI TLSDGTFLPK GTLVAVPAYS THRDDAVYAD ALVFDPFRFS RMRAREGEGT 
                 420 
               
               
                   
               
               
                 KHQFVNTSVE YVPFGHGKHA CPGRFFAANE LKAMLAYIVL NYDVKLPGDG KRPLNMYWGP 
                 480 
               
               
                   
               
               
                 TVLPAPAGQV LFRKRQVSL 
                 499 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 75 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggcatttt tctctatgat ttcaattttg ttgggatttg ttatttcttc tttcatcttc 
                 60 
               
               
                   
               
               
                 atctttttct tcaaaaagtt acttagtttt agtaggaaaa acatgtcaga agtttctact 
                 120 
               
               
                   
               
               
                 ttgccaagtg ttccagtagt gcctggtttt ccagttattg ggaatttgtt gcaactaaag 
                 180 
               
               
                   
               
               
                 gagaaaaagc ctcataaaac tttcactaga tggtcagaga tatatggacc tatctactct 
                 240 
               
               
                   
               
               
                 ataaagatgg gttcttcatc tcttattgta ttgaacagta cagaaactgc taaggaagca 
                 300 
               
               
                   
               
               
                 atggtcacta gattttcatc aatatctacc agaaaattgt caaacgccct aacagttcta 
                 360 
               
               
                   
               
               
                 acctgcgata agtctatggt cgccacttct gattatgatg acttccacaa attagttaag 
                 420 
               
               
                   
               
               
                 agatgtttgc taaatggact tcttggtgct aatgctcaaa agagaaaaag acactacaga 
                 480 
               
               
                   
               
               
                 gatgctttga ttgaaaatgt gagttccaag ctacatgcac acgctagaga tcatccacaa 
                 540 
               
               
                   
               
               
                 gagccagtta actttagagc aattttcgaa cacgaattgt ttggtgtagc attaaagcaa 
                 600 
               
               
                   
               
               
                 gccttcggta aagacgtaga atccatatac gtcaaggagt taggcgtaac attatcaaaa 
                 660 
               
               
                   
               
               
                 gatgaaatct ttaaggtgct tgtacatgat atgatggagg gtgcaattga tgtagattgg 
                 720 
               
               
                   
               
               
                 agagatttct tcccatattt gaaatggatc cctaataagt cttttgaagc taggatacaa 
                 780 
               
               
                   
               
               
                 caaaagcaca agagaagact agctgttatg aacgcactta tacaggacag attgaagcaa 
                 840 
               
               
                   
               
               
                 aatgggtctg aatcagatga tgattgttac cttaacttct taatgtctga ggctaaaaca 
                 900 
               
               
                   
               
               
                 ttgactaagg aacagatcgc aatccttgtc tgggaaacaa tcattgaaac agcagatact 
                 960 
               
               
                   
               
               
                 accttagtca caactgaatg ggccatatac gagctagcca aacatccatc tgtgcaagat 
                 1020 
               
               
                   
               
               
                 aggttgtgta aggagatcca gaacgtgtgt ggtggagaga aattcaagga agagcagttg 
                 1080 
               
               
                   
               
               
                 tcacaagttc cttaccttaa cggcgttttc catgaaacct tgagaaaata ctcacctgca 
                 1140 
               
               
                   
               
               
                 ccattagttc ctattagata cgcccacgaa gatacacaaa tcggtggcta ccatgttcca 
                 1200 
               
               
                   
               
               
                 gctgggtccg aaattgctat aaacatctac gggtgcaaca tggacaaaaa gagatgggaa 
                 1260 
               
               
                   
               
               
                 agaccagaag attggtggcc agaaagattc ttagatgatg gcaaatatga aacatctgat 
                 1320 
               
               
                   
               
               
                 ttgcataaaa caatggcttt cggagctggc aaaagagtgt gtgccggtgc tctacaagcc 
                 1380 
               
               
                   
               
               
                 tccctaatgg ctggtatcgc tattggtaga ttggtccaag agttcgaatg gaaacttaga 
                 1440 
               
               
                   
               
               
                 gatggtgaag aggaaaatgt cgatacttat gggttaacat ctcaaaagtt atacccacta 
                 1500 
               
               
                   
               
               
                 atggcaatca tcaatcctag aagatcctaa 
                 1530 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 76 
               
               
                 
                   A. thaliana 
                 
               
            
           
           
               
               
            
               
                 MAFFSMISIL LGFVISSFIF IFFFKKLLSF SRKNMSEVST LPSVPVVPGF PVIGNLLQLK 
                 60 
               
               
                   
               
               
                 EKKPHKTFTR WSEIYGPIYS IKMGSSSLIV LNSTETAKEA MVTRFSSIST RKLSNALTVL 
                 120 
               
               
                   
               
               
                 TCDKSMVATS DYDDFHKLVK RCLLNGLLGA NAQKRKRHYR DALIENVSSK LHAHARDHPQ 
                 180 
               
               
                   
               
               
                 EPVNFRAIFE HELFGVALKQ AFGKDVESIY VKELGVTLSK DEIFKVLVHD MMEGAIDVDW 
                 240 
               
               
                   
               
               
                 RDFFPYLKWI PNKSFEARIQ QKHKRRLAVM NALIQDRLKQ NGSESDDDCY LNFLMSEAKT 
                 300 
               
               
                   
               
               
                 LTKEQIAILV WETIIETADT TLVTTEWAIY ELAKHPSVQD RLCKEIQNVC GGEKFKEEQL 
                 360 
               
               
                   
               
               
                 SQVPYLNGVF HETLRKYSPA PLVPIRYAHE DTQIGGYHVP AGSEIAINIY GCNMDKKRWE 
                 420 
               
               
                   
               
               
                 RPEDWWPERF LDDGKYETSD LHKTMAFGAG KRVCAGALQA SLMAGIAIGR LVQEFEWKLR 
                 480 
               
               
                   
               
               
                 DGEEENVDTY GLTSQKLYPL MAIINPRRS 
                 509 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 77 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgcaatcag attcagtcaa agtctctcca tttgatttgg tttccgctgc tatgaatggc 
                 60 
               
               
                   
               
               
                 aaggcaatgg aaaagttgaa cgctagtgaa tctgaagatc caacaacatt gcctgcacta 
                 120 
               
               
                   
               
               
                 aagatgctag ttgaaaatag agaattgttg acactgttca caacttcctt cgcagttctt 
                 180 
               
               
                   
               
               
                 attgggtgtc ttgtatttct aatgtggaga cgttcatcct ctaaaaagct ggtacaagat 
                 240 
               
               
                   
               
               
                 ccagttccac aagttatcgt tgtaaagaag aaagagaagg agtcagaggt tgatgacggg 
                 300 
               
               
                   
               
               
                 aaaaagaaag tttctatttt ctacggcaca caaacaggaa ctgccgaagg ttttgctaaa 
                 360 
               
               
                   
               
               
                 gcattagtcg aggaagcaaa agtgagatat gaaaagacct ctttcaaggt tatcgatcta 
                 420 
               
               
                   
               
               
                 gatgactacg ctgcagatga tgatgaatat gaggaaaaac tgaaaaagga atccttagcc 
                 480 
               
               
                   
               
               
                 ttcttcttct tggccacata cggtgatggt gaacctactg ataatgctgc taacttctac 
                 540 
               
               
                   
               
               
                 aagtggttca cagaaggcga cgataaaggt gaatggctga aaaagttaca atacggagta 
                 600 
               
               
                   
               
               
                 tttggtttag gtaacagaca atatgaacat ttcaacaaga tcgctattgt agttgatgat 
                 660 
               
               
                   
               
               
                 aaacttactg aaatgggagc caaaagatta gtaccagtag gattagggga tgatgatcag 
                 720 
               
               
                   
               
               
                 tgtatagaag atgacttcac cgcctggaag gaattggtat ggccagaatt ggatcaactt 
                 780 
               
               
                   
               
               
                 ttaagggacg aagatgatac ttctgtgact accccataca ctgcagccgt attggagtac 
                 840 
               
               
                   
               
               
                 agagtggttt accatgataa accagcagac tcatatgctg aagatcaaac ccatacaaac 
                 900 
               
               
                   
               
               
                 ggtcatgttg ttcatgatgc acagcatcct tcaagatcta atgtggcttt caaaaaggaa 
                 960 
               
               
                   
               
               
                 ctacacacct ctcaatcaga taggtcttgt actcacttag aattcgatat ttctcacaca 
                 1020 
               
               
                   
               
               
                 ggactgtctt acgaaactgg cgatcacgtt ggcgtttatt ccgagaactt gtccgaagtt 
                 1080 
               
               
                   
               
               
                 gtcgatgaag cactaaaact gttagggtta tcaccagaca catacttctc agtccatgct 
                 1140 
               
               
                   
               
               
                 gataaggagg atgggacacc tatcggtggt gcttcactac caccaccttt tcctccttgc 
                 1200 
               
               
                   
               
               
                 acattgagag acgctctaac cagatacgca gatgtcttat cctcacctaa aaaggtagct 
                 1260 
               
               
                   
               
               
                 ttgctggcat tggctgctca tgctagtgat cctagtgaag ccgataggtt aaagttcctg 
                 1320 
               
               
                   
               
               
                 gcttcaccag ccggaaaaga tgaatatgca caatggatcg tcgccaacca acgttctttg 
                 1380 
               
               
                   
               
               
                 ctagaagtga tgcaaagttt tccatctgcc aagcctccat taggtgtgtt cttcgcagca 
                 1440 
               
               
                   
               
               
                 gtagctccac gtttacaacc aagatactac tctatcagtt catctcctaa gatgtctcct 
                 1500 
               
               
                   
               
               
                 aacagaatac atgttacatg tgctttggtg tacgagacta ctccagcagg cagaattcac 
                 1560 
               
               
                   
               
               
                 agaggattgt gttcaacctg gatgaaaaat gctgtccctt taacagagtc acctgattgc 
                 1620 
               
               
                   
               
               
                 tctcaagcat ccattttcgt tagaacatca aatttcagac ttccagtgga tccaaaagtt 
                 1680 
               
               
                   
               
               
                 ccagtcatta tgataggacc aggcactggt cttgccccat tcaggggctt tcttcaagag 
                 1740 
               
               
                   
               
               
                 agattggcct tgaaggaatc tggtacagaa ttgggttctt ctatcttttt ctttggttgc 
                 1800 
               
               
                   
               
               
                 cgtaatagaa aagttgactt tatctacgag gacgagctta acaattttgt tgagacagga 
                 1860 
               
               
                   
               
               
                 gcattgtcag aattgatcgt cgcattttca agagaaggga ctgccaaaga gtacgttcag 
                 1920 
               
               
                   
               
               
                 cacaagatga gtcaaaaagc ctccgatata tggaaacttc taagtgaagg tgcctatctt 
                 1980 
               
               
                   
               
               
                 tatgtctgtg gcgatgcaaa gggcatggcc aaggatgtcc atagaactct gcatacaatt 
                 2040 
               
               
                   
               
               
                 gttcaggaac aagggagtct ggattcttcc aaggctgaat tgtacgtcaa aaacttacag 
                 2100 
               
               
                   
               
               
                 atgtctggaa gatacttaag agatgtttgg taa 
                 2133 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 78 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MQSDSVKVSP FDLVSAAMNG KAMEKLNASE SEDPTTLPAL KMLVENRELL TLFTTSFAVL 
                 60 
               
               
                   
               
               
                 IGCLVFLMWR RSSSKKLVQD PVPQVIVVKK KEKESEVDDG KKKVSIFYGT QTGTAEGFAK 
                 120 
               
               
                   
               
               
                 ALVEEAKVRY EKTSFKVIDL DDYAADDDEY EEKLKKESLA FFFLATYGDG EPTDNAANFY 
                 180 
               
               
                   
               
               
                 KWFTEGDDKG EWLKKLQYGV FGLGNRQYEH FNKIAIVVDD KLTEMGAKRL VPVGLGDDDQ 
                 240 
               
               
                   
               
               
                 CIEDDFTAWK ELVWPELDQL LRDEDDTSVT TPYTAAVLEY RVVYHDKPAD SYAEDQTHTN 
                 300 
               
               
                   
               
               
                 GHVVHDAQHP SRSNVAFKKE LHTSQSDRSC THLEFDISHT GLSYETGDHV GVYSENLSEV 
                 360 
               
               
                   
               
               
                 VDEALKLLGL SPDTYFSVHA DKEDGTPIGG ASLPPPFPPC TLRDALTRYA DVLSSPKKVA 
                 420 
               
               
                   
               
               
                 LLALAAHASD PSEADRLKFL ASPAGKDEYA QWIVANQRSL LEVMQSFPSA KPPLGVFFAA 
                 480 
               
               
                   
               
               
                 VAPRLQPRYY SISSSPKMSP NRIHVTCALV YETTPAGRIH RGLCSTWMKN AVPLTESPDC 
                 540 
               
               
                   
               
               
                 SQASIFVRTS NFRLPVDPKV PVIMIGPGTG LAPFRGFLQE RLALKESGTE LGSSIFFFGC 
                 600 
               
               
                   
               
               
                 RNRKVDFIYE DELNNFVETG ALSELIVAFS REGTAKEYVQ HKMSQKASDI WKLLSEGAYL 
                 660 
               
               
                   
               
               
                 YVCGDAKGMA KDVHRTLHTI VQEQGSLDSS KAELYVKNLQ MSGRYLRDVW 
                 710 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 79 
               
               
                 
                   S. grosvenorii 
                 
               
            
           
           
               
               
            
               
                 atgaaggtca gtccattcga attcatgtcc gctattatca agggtagaat ggacccatct 
                 60 
               
               
                   
               
               
                 aactcctcat ttgaatctac tggtgaagtt gcctccgtta tctttgaaaa cagagaattg 
                 120 
               
               
                   
               
               
                 gttgccatct tgaccacttc tattgctgtt atgattggtt gcttcgttgt cttgatgtgg 
                 180 
               
               
                   
               
               
                 agaagagctg gttctagaaa ggttaagaat gtcgaattgc caaagccatt gattgtccat 
                 240 
               
               
                   
               
               
                 gaaccagaac ctgaagttga agatggtaag aagaaggttt ccatcttctt cggtactcaa 
                 300 
               
               
                   
               
               
                 actggtactg ctgaaggttt tgctaaggct ttggctgatg aagctaaagc tagatacgaa 
                 360 
               
               
                   
               
               
                 aaggctacct tcagagttgt tgatttggat gattatgctg ccgatgatga ccaatacgaa 
                 420 
               
               
                   
               
               
                 gaaaaattga agaacgaatc cttcgccgtt ttcttgttgg ctacttatgg tgatggtgaa 
                 480 
               
               
                   
               
               
                 cctactgata atgctgctag attttacaag tggttcgccg aaggtaaaga aagaggtgaa 
                 540 
               
               
                   
               
               
                 tggttgcaaa acttgcacta tgctgttttt ggtttgggta acagacaata cgaacacttc 
                 600 
               
               
                   
               
               
                 aacaagattg ctaaggttgc cgacgaatta ttggaagctc aaggtggtaa tagattggtt 
                 660 
               
               
                   
               
               
                 aaggttggtt taggtgatga cgatcaatgc atcgaagatg atttttctgc ttggagagaa 
                 720 
               
               
                   
               
               
                 tctttgtggc cagaattgga tatgttgttg agagatgaag atgatgctac tactgttact 
                 780 
               
               
                   
               
               
                 actccatata ctgctgctgt cttggaatac agagttgtct ttcatgattc tgctgatgtt 
                 840 
               
               
                   
               
               
                 gctgctgaag ataagtcttg gattaacgct aatggtcatg ctgttcatga tgctcaacat 
                 900 
               
               
                   
               
               
                 ccattcagat ctaacgttgt cgtcagaaaa gaattgcata cttctgcctc tgatagatcc 
                 960 
               
               
                   
               
               
                 tgttctcatt tggaattcaa catttccggt tccgctttga attacgaaac tggtgatcat 
                 1020 
               
               
                   
               
               
                 gttggtgtct actgtgaaaa cttgactgaa actgttgatg aagccttgaa cttgttgggt 
                 1080 
               
               
                   
               
               
                 ttgtctccag aaacttactt ctctatctac accgataacg aagatggtac tccattgggt 
                 1140 
               
               
                   
               
               
                 ggttcttcat tgccaccacc atttccatca tgtactttga gaactgcttt gaccagatac 
                 1200 
               
               
                   
               
               
                 gctgatttgt tgaactctcc aaaaaagtct gctttgttgg ctttagctgc tcatgcttct 
                 1260 
               
               
                   
               
               
                 aatccagttg aagctgatag attgagatac ttggcttctc cagctggtaa agatgaatat 
                 1320 
               
               
                   
               
               
                 gcccaatctg ttatcggttc ccaaaagtct ttgttggaag ttatggctga attcccatct 
                 1380 
               
               
                   
               
               
                 gctaaaccac cattaggtgt tttttttgct gctgttgctc caagattgca acctagattc 
                 1440 
               
               
                   
               
               
                 tactccattt catcctctcc aagaatggct ccatctagaa tccatgttac ttgtgctttg 
                 1500 
               
               
                   
               
               
                 gtttacgata agatgccaac tggtagaatt cataagggtg tttgttctac ctggatgaag 
                 1560 
               
               
                   
               
               
                 aattctgttc caatggaaaa gtcccatgaa tgttcttggg ctccaatttt cgttagacaa 
                 1620 
               
               
                   
               
               
                 tccaatttta agttgccagc cgaatccaag gttccaatta tcatggttgg tccaggtact 
                 1680 
               
               
                   
               
               
                 ggtttggctc cttttagagg ttttttacaa gaaagattgg ccttgaaaga atccggtgtt 
                 1740 
               
               
                   
               
               
                 gaattgggtc catccatttt gtttttcggt tgcagaaaca gaagaatgga ttacatctac 
                 1800 
               
               
                   
               
               
                 gaagatgaat tgaacaactt cgttgaaacc ggtgctttgt ccgaattggt tattgctttt 
                 1860 
               
               
                   
               
               
                 tctagagaag gtcctaccaa agaatacgtc caacataaga tggctgaaaa ggcttctgat 
                 1920 
               
               
                   
               
               
                 atctggaact tgatttctga aggtgcttac ttgtacgttt gtggtgatgc taaaggtatg 
                 1980 
               
               
                   
               
               
                 gctaaggatg ttcatagaac cttgcatacc atcatgcaag aacaaggttc tttggattct 
                 2040 
               
               
                   
               
               
                 tccaaagctg aatccatggt caagaacttg caaatgaatg gtagatactt aagagatgtt 
                 2100 
               
               
                   
               
               
                 tggtaa 
                 2106 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 80 
               
               
                 
                   S. grosvenorii 
                 
               
            
           
           
               
               
            
               
                 MKVSPFEFMS AIIKGRMDPS NSSFESTGEV ASVIFENREL VAILTTSIAV MIGCFVVLMW 
                 60 
               
               
                   
               
               
                 RRAGSRKVKN VELPKPLIVH EPEPEVEDGK KKVSIFFGTQ TGTAEGFAKA LADEAKARYE 
                 120 
               
               
                   
               
               
                 KATFRVVDLD DYAADDDQYE EKLKNESFAV FLLATYGDGE PTDNAARFYK WFAEGKERGE 
                 180 
               
               
                   
               
               
                 WLQNLHYAVF GLGNRQYEHF NKIAKVADEL LEAQGGNRLV KVGLGDDDQC IEDDFSAWRE 
                 240 
               
               
                   
               
               
                 SLWPELDMLL RDEDDATTVT TPYTAAVLEY RVVFHDSADV AAEDKSWINA NGHAVHDAQH 
                 300 
               
               
                   
               
               
                 PFRSNVVVRK ELHTSASDRS CSHLEFNISG SALNYETGDH VGVYCENLTE TVDEALNLLG 
                 360 
               
               
                   
               
               
                 LSPETYFSIY TDNEDGTPLG GSSLPPPFPS CTLRTALTRY ADLLNSPKKS ALLALAAHAS 
                 420 
               
               
                   
               
               
                 NPVEADRLRY LASPAGKDEY AQSVIGSQKS LLEVMAEFPS AKPPLGVFFA AVAPRLQPRF 
                 480 
               
               
                   
               
               
                 YSISSSPRMA PSRIHVTCAL VYDKMPTGRI HKGVCSTWMK NSVPMEKSHE CSWAPIFVRQ 
                 540 
               
               
                   
               
               
                 SNFKLPAESK VPIIMVGPGT GLAPFRGFLQ ERLALKESGV ELGPSILFFG CRNRRMDYIY 
                 600 
               
               
                   
               
               
                 EDELNNFVET GALSELVIAF SREGPTKEYV QHKMAEKASD IWNLISEGAY LYVCGDAKGM 
                 660 
               
               
                   
               
               
                 AKDVHRTLHT IMQEQGSLDS SKAESMVKNL QMNGRYLRDV W 
                 701 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 81 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggcagaat tagatacact tgatatagta gtattaggtg ttatcttttt gggtactgtg 
                 60 
               
               
                   
               
               
                 gcatacttta ctaagggtaa attgtggggt gttaccaagg atccatacgc taacggattc 
                 120 
               
               
                   
               
               
                 gctgcaggtg gtgcttccaa gcctggcaga actagaaaca tcgtcgaagc tatggaggaa 
                 180 
               
               
                   
               
               
                 tcaggtaaaa actgtgttgt tttctacggc agtcaaacag gtacagcgga ggattacgca 
                 240 
               
               
                   
               
               
                 tcaagacttg caaaggaagg aaagtccaga ttcggtttga acactatgat cgccgatcta 
                 300 
               
               
                   
               
               
                 gaagattatg acttcgataa cttagacact gttccatctg ataacatcgt tatgtttgta 
                 360 
               
               
                   
               
               
                 ttggctactt acggtgaagg cgaaccaaca gataacgccg tggatttcta tgagttcatt 
                 420 
               
               
                   
               
               
                 actggcgaag atgcctcttt caatgagggc aacgatcctc cactaggtaa cttgaattac 
                 480 
               
               
                   
               
               
                 gttgcgttcg gtctgggcaa caatacctac gaacactaca actcaatggt caggaacgtt 
                 540 
               
               
                   
               
               
                 aacaaggctc tagaaaagtt aggagctcat agaattggag aagcaggtga gggtgacgac 
                 600 
               
               
                   
               
               
                 ggagctggaa ctatggaaga ggacttttta gcttggaaag atccaatgtg ggaagccttg 
                 660 
               
               
                   
               
               
                 gctaaaaaga tgggcttgga ggaaagagaa gctgtatatg aacctatttt cgctatcaat 
                 720 
               
               
                   
               
               
                 gagagagatg atttgacccc tgaagcgaat gaggtatact tgggagaacc taataagcta 
                 780 
               
               
                   
               
               
                 cacttggaag gtacagcgaa aggtccattc aactcccaca acccatatat cgcaccaatt 
                 840 
               
               
                   
               
               
                 gcagaatcat acgaactttt ctcagctaag gatagaaatt gtctgcatat ggaaattgat 
                 900 
               
               
                   
               
               
                 atttctggta gtaatctaaa gtatgaaaca ggcgaccata tcgcgatctg gcctaccaac 
                 960 
               
               
                   
               
               
                 ccaggtgaag aggtcaacaa atttcttgac attctagatc tgtctggtaa gcaacattcc 
                 1020 
               
               
                   
               
               
                 gtcgtaacag tgaaagcctt agaacctaca gccaaagttc cttttccaaa tccaactacc 
                 1080 
               
               
                   
               
               
                 tacgatgcta tattgagata ccatctggaa atatgcgctc cagtttctag acagtttgtc 
                 1140 
               
               
                   
               
               
                 tcaactttag cagcattcgc ccctaatgat gatatcaaag ctgagatgaa ccgtttggga 
                 1200 
               
               
                   
               
               
                 tcagacaaag attacttcca cgaaaagaca ggaccacatt actacaatat cgctagattt 
                 1260 
               
               
                   
               
               
                 ttggcctcag tctctaaagg tgaaaaatgg acaaagatac cattttctgc tttcatagaa 
                 1320 
               
               
                   
               
               
                 ggccttacaa aactacaacc aagatactat tctatctctt cctctagttt agttcagcct 
                 1380 
               
               
                   
               
               
                 aaaaagatta gtattactgc tgttgtcgaa tctcagcaaa ttccaggtag agatgaccca 
                 1440 
               
               
                   
               
               
                 ttcagaggtg tagcgactaa ctacttgttc gctttgaagc agaaacaaaa cggtgatcca 
                 1500 
               
               
                   
               
               
                 aatccagctc cttttggcca atcatacgag ttgacaggac caaggaataa gtatgatggt 
                 1560 
               
               
                   
               
               
                 atacatgttc cagtccatgt aagacattct aactttaagc taccatctga tccaggcaaa 
                 1620 
               
               
                   
               
               
                 cctattatca tgatcggtcc aggtaccggt gttgcccctt ttagaggctt cgtccaagag 
                 1680 
               
               
                   
               
               
                 agggcaaaac aagccagaga tggtgtagaa gttggtaaaa cactgctgtt ctttggatgt 
                 1740 
               
               
                   
               
               
                 agaaagagta cagaagattt catgtatcaa aaagagtggc aagagtacaa ggaagctctt 
                 1800 
               
               
                   
               
               
                 ggcgacaaat tcgaaatgat tacagctttt tcaagagaag gatctaaaaa ggtttatgtt 
                 1860 
               
               
                   
               
               
                 caacacagac tgaaggaaag atcaaaggaa gtttctgatc ttctatccca aaaagcatac 
                 1920 
               
               
                   
               
               
                 ttctacgttt gcggagacgc cgcacatatg gcacgtgaag tgaacactgt gttagcacag 
                 1980 
               
               
                   
               
               
                 atcatagcag aaggccgtgg tgtatcagaa gccaagggtg aggaaattgt caaaaacatg 
                 2040 
               
               
                   
               
               
                 agatcagcaa atcaatacca agtgtgttct gatttcgtaa ctttacactg taaagagaca 
                 2100 
               
               
                   
               
               
                 acatacgcga attcagaatt gcaagaggat gtctggagtt aa 
                 2142 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 82 
               
               
                 
                   G. fujikuroi 
                 
               
            
           
           
               
               
            
               
                 MAELDTLDIV VLGVIFLGTV AYFTKGKLWG VTKDPYANGF AAGGASKPGR TRNIVEAMEE 
                 60 
               
               
                   
               
               
                 SGKNCVVFYG SQTGTAEDYA SRLAKEGKSR FGLNTMIADL EDYDFDNLDT VPSDNIVMFV 
                 120 
               
               
                   
               
               
                 LATYGEGEPT DNAVDFYEFI TGEDASFNEG NDPPLGNLNY VAFGLGNNTY EHYNSMVRNV 
                 180 
               
               
                   
               
               
                 NKALEKLGAH RIGEAGEGDD GAGTMEEDFL AWKDPMWEAL AKKMGLEERE AVYEPIFAIN 
                 240 
               
               
                   
               
               
                 ERDDLTPEAN EVYLGEPNKL HLEGTAKGPF NSHNPYIAPI AESYELFSAK DRNCLHMEID 
                 300 
               
               
                   
               
               
                 ISGSNLKYET GDHIAIWPTN PGEEVNKFLD ILDLSGKQHS VVTVKALEPT AKVPFPNPTT 
                 360 
               
               
                   
               
               
                 YDAILRYHLE ICAPVSRQFV STLAAFAPND DIKAEMNRLG SDKDYFHEKT GPHYYNIARF 
                 420 
               
               
                   
               
               
                 LASVSKGEKW TKIPFSAFIE GLTKLQPRYY SISSSSLVQP KKISITAVVE SQQIPGRDDP 
                 480 
               
               
                   
               
               
                 FRGVATNYLF ALKQKQNGDP NPAPFGQSYE LTGPRNKYDG IHVPVHVRHS NFKLPSDPGK 
                 540 
               
               
                   
               
               
                 PIIMIGPGTG VAPFRGFVQE RAKQARDGVE VGKTLLFFGC RKSTEDFMYQ KEWQEYKEAL 
                 600 
               
               
                   
               
               
                 GDKFEMITAF SREGSKKVYV QHRLKERSKE VSDLLSQKAY FYVCGDAAHM AREVNTVLAQ 
                 660 
               
               
                   
               
               
                 IIAEGRGVSE AKGEEIVKNM RSANQYQVCS DFVTLHCKET TYANSELQED VWS 
                 713 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 83 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 atgcaatcgg aatccgttga agcatcgacg attgatttga tgactgctgt tttgaaggac 
                 60 
               
               
                   
               
               
                 acagtgatcg atacagcgaa cgcatctgat aacggagact caaagatgcc gccggcgttg 
                 120 
               
               
                   
               
               
                 gcgatgatgt tcgaaattcg tgatctgttg ctgattttga ctacgtcagt tgctgttttg 
                 180 
               
               
                   
               
               
                 gtcggatgtt tcgttgtttt ggtgtggaag agatcgtccg ggaagaagtc cggcaaggaa 
                 240 
               
               
                   
               
               
                 ttggagccgc cgaagatcgt tgtgccgaag aggcggctgg agcaggaggt tgatgatggt 
                 300 
               
               
                   
               
               
                 aagaagaagg ttacgatttt cttcggaaca caaactggaa cggctgaagg tttcgctaag 
                 360 
               
               
                   
               
               
                 gcacttttcg aagaagcgaa agcgcgatat gaaaaggcag cgtttaaagt gattgatttg 
                 420 
               
               
                   
               
               
                 gatgattatg ctgctgattt ggatgagtat gcagagaagc tgaagaagga aacatatgct 
                 480 
               
               
                   
               
               
                 ttcttcttct tggctacata tggagatggt gagccaactg ataatgctgc caaattttat 
                 540 
               
               
                   
               
               
                 aaatggttta ctgagggaga cgagaaaggc gtttggcttc aaaaacttca atatggagta 
                 600 
               
               
                   
               
               
                 tttggtcttg gcaacagaca atatgaacat ttcaacaaga ttggaatagt ggttgatgat 
                 660 
               
               
                   
               
               
                 ggtctcaccg agcagggtgc aaaacgcatt gttcccgttg gtcttggaga cgacgatcaa 
                 720 
               
               
                   
               
               
                 tcaattgaag acgatttttc ggcatggaaa gagttagtgt ggcccgaatt ggatctattg 
                 780 
               
               
                   
               
               
                 cttcgcgatg aagatgacaa agctgctgca actccttaca cagctgcaat ccctgaatac 
                 840 
               
               
                   
               
               
                 cgcgtcgtat ttcatgacaa acccgatgcg ttttctgatg atcatactca aaccaatggt 
                 900 
               
               
                   
               
               
                 catgctgttc atgatgctca acatccatgc agatccaatg tggctgttaa aaaagagctt 
                 960 
               
               
                   
               
               
                 catactcctg aatccgatcg ttcatgcaca catcttgaat ttgacatttc tcacactgga 
                 1020 
               
               
                   
               
               
                 ttatcttatg aaactgggga tcatgttggt gtatactgtg aaaacctaat tgaagtagtg 
                 1080 
               
               
                   
               
               
                 gaagaagctg ggaaattgtt aggattatca acagatactt atttctcgtt acatattgat 
                 1140 
               
               
                   
               
               
                 aacgaagatg gttcaccact tggtggacct tcattacaac ctccttttcc tccttgtact 
                 1200 
               
               
                   
               
               
                 ttaagaaaag cattgactaa ttatgcagat ctgttaagct ctcccaaaaa gtcaactttg 
                 1260 
               
               
                   
               
               
                 cttgctctag ctgctcatgc ttccgatccc actgaagctg atcgtttaag atttcttgca 
                 1320 
               
               
                   
               
               
                 tctcgcgagg gcaaggatga atatgctgaa tgggttgttg caaaccaaag aagtcttctt 
                 1380 
               
               
                   
               
               
                 gaagtcatgg aagctttccc gtcagctaga ccgccacttg gtgttttctt tgcagcggtt 
                 1440 
               
               
                   
               
               
                 gcaccgcgtt tacagcctcg ttactactct atttcttcct ccccaaagat ggaaccaaac 
                 1500 
               
               
                   
               
               
                 aggattcatg ttacttgcgc gttggtttat gaaaaaactc ccgcaggtcg tatccacaaa 
                 1560 
               
               
                   
               
               
                 ggaatctgct caacctggat gaagaacgct gtacctttga ccgaaagtca agattgcagt 
                 1620 
               
               
                   
               
               
                 tgggcaccga tttttgttag aacatcaaac ttcagacttc caattgaccc gaaagtcccg 
                 1680 
               
               
                   
               
               
                 gttatcatga ttggtcctgg aaccgggttg gctccattta ggggttttct tcaagaaaga 
                 1740 
               
               
                   
               
               
                 ttggctctta aagaatccgg aaccgaactc gggtcatcta ttttattctt cggttgtaga 
                 1800 
               
               
                   
               
               
                 aaccgcaaag tggattacat atatgagaat gaactcaaca actttgttga aaatggtgcg 
                 1860 
               
               
                   
               
               
                 ctttctgagc ttgatgttgc tttctcccgc gatggcccga cgaaagaata cgtgcaacat 
                 1920 
               
               
                   
               
               
                 aaaatgaccc aaaaggcttc tgaaatatgg aatatgcttt ctgagggagc atatttatat 
                 1980 
               
               
                   
               
               
                 gtatgtggtg atgctaaagg catggctaaa gatgtacacc gtacacttca caccattgtg 
                 2040 
               
               
                   
               
               
                 caagaacagg gaagtttgga ctcgtctaaa gcggagttgt atgtgaagaa tctacaaatg 
                 2100 
               
               
                   
               
               
                 tcaggaagat acctccgtga tgtttggtaa 
                 2130 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 84 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MQSESVEAST IDLMTAVLKD TVIDTANASD NGDSKMPPAL AMMFEIRDLL LILTTSVAVL 
                 60 
               
               
                   
               
               
                 VGCFVVLVWK RSSGKKSGKE LEPPKIVVPK RRLEQEVDDG KKKVTIFFGT QTGTAEGFAK 
                 120 
               
               
                   
               
               
                 ALFEEAKARY EKAAFKVIDL DDYAADLDEY AEKLKKETYA FFFLATYGDG EPTDNAAKFY 
                 180 
               
               
                   
               
               
                 KWFTEGDEKG VWLQKLQYGV FGLGNRQYEH FNKIGIVVDD GLTEQGAKRI VPVGLGDDDQ 
                 240 
               
               
                   
               
               
                 SIEDDFSAWK ELVWPELDLL LRDEDDKAAA TPYTAAIPEY RVVFHDKPDA FSDDHTQTNG 
                 300 
               
               
                   
               
               
                 HAVHDAQHPC RSNVAVKKEL HTPESDRSCT HLEFDISHTG LSYETGDHVG VYCENLIEVV 
                 360 
               
               
                   
               
               
                 EEAGKLLGLS TDTYFSLHID NEDGSPLGGP SLQPPFPPCT LRKALTNYAD LLSSPKKSTL 
                 420 
               
               
                   
               
               
                 LALAAHASDP TEADRLRFLA SREGKDEYAE WVVANQRSLL EVMEAFPSAR PPLGVFFAAV 
                 480 
               
               
                   
               
               
                 APRLQPRYYS ISSSPKMEPN RIHVTCALVY EKTPAGRIHK GICSTWMKNA VPLTESQDCS 
                 540 
               
               
                   
               
               
                 WAPIFVRTSN FRLPIDPKVP VIMIGPGTGL APFRGFLQER LALKESGTEL GSSILFFGCR 
                 600 
               
               
                   
               
               
                 NRKVDYIYEN ELNNFVENGA LSELDVAFSR DGPTKEYVQH KMTQKASEIW NMLSEGAYLY 
                 660 
               
               
                   
               
               
                 VCGDAKGMAK DVHRTLHTIV QEQGSLDSSK AELYVKNLQM SGRYLRDVW 
                 709 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 85 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgcaatcta actccgtgaa gatttcgccg cttgatctgg taactgcgct gtttagcggc 
                 60 
               
               
                   
               
               
                 aaggttttgg acacatcgaa cgcatcggaa tcgggagaat ctgctatgct gccgactata 
                 120 
               
               
                   
               
               
                 gcgatgatta tggagaatcg tgagctgttg atgatactca caacgtcggt tgctgtattg 
                 180 
               
               
                   
               
               
                 atcggatgcg ttgtcgtttt ggtgtggcgg agatcgtcta cgaagaagtc ggcgttggag 
                 240 
               
               
                   
               
               
                 ccaccggtga ttgtggttcc gaagagagtg caagaggagg aagttgatga tggtaagaag 
                 300 
               
               
                   
               
               
                 aaagttacgg ttttcttcgg cacccaaact ggaacagctg aaggcttcgc taaggcactt 
                 360 
               
               
                   
               
               
                 gttgaggaag ctaaagctcg atatgaaaag gctgtcttta aagtaattga tttggatgat 
                 420 
               
               
                   
               
               
                 tatgctgctg atgacgatga gtatgaggag aaactaaaga aagaatcttt ggcctttttc 
                 480 
               
               
                   
               
               
                 tttttggcta cgtatggaga tggtgagcca acagataatg ctgccagatt ttataaatgg 
                 540 
               
               
                   
               
               
                 tttactgagg gagatgcgaa aggagaatgg cttaataagc ttcaatatgg agtatttggt 
                 600 
               
               
                   
               
               
                 ttgggtaaca gacaatatga acattttaac aagatcgcaa aagtggttga tgatggtctt 
                 660 
               
               
                   
               
               
                 gtagaacagg gtgcaaagcg tcttgttcct gttggacttg gagatgatga tcaatgtatt 
                 720 
               
               
                   
               
               
                 gaagatgact tcaccgcatg gaaagagtta gtatggccgg agttggatca attacttcgt 
                 780 
               
               
                   
               
               
                 gatgaggatg acacaactgt tgctactcca tacacagctg ctgttgcaga atatcgcgtt 
                 840 
               
               
                   
               
               
                 gtttttcatg aaaaaccaga cgcgctttct gaagattata gttatacaaa tggccatgct 
                 900 
               
               
                   
               
               
                 gttcatgatg ctcaacatcc atgcagatcc aacgtggctg tcaaaaagga acttcatagt 
                 960 
               
               
                   
               
               
                 cctgaatctg accggtcttg cactcatctt gaatttgaca tctcgaacac cggactatca 
                 1020 
               
               
                   
               
               
                 tatgaaactg gggaccatgt tggagtttac tgtgaaaact tgagtgaagt tgtgaatgat 
                 1080 
               
               
                   
               
               
                 gctgaaagat tagtaggatt accaccagac acttactcct ccatccacac tgatagtgaa 
                 1140 
               
               
                   
               
               
                 gacgggtcgc cacttggcgg agcctcattg ccgcctcctt tcccgccatg cactttaagg 
                 1200 
               
               
                   
               
               
                 aaagcattga cgtgttatgc tgatgttttg agttctccca agaagtcggc tttgcttgca 
                 1260 
               
               
                   
               
               
                 ctagctgctc atgccaccga tcccagtgaa gctgatagat tgaaatttct tgcatccccc 
                 1320 
               
               
                   
               
               
                 gccggaaagg atgaatattc tcaatggata gttgcaagcc aaagaagtct ccttgaagtc 
                 1380 
               
               
                   
               
               
                 atggaagcat tcccgtcagc taagccttca cttggtgttt tctttgcatc tgttgccccg 
                 1440 
               
               
                   
               
               
                 cgcttacaac caagatacta ctctatttct tcctcaccca agatggcacc ggataggatt 
                 1500 
               
               
                   
               
               
                 catgttacat gtgcattagt ctatgagaaa acacctgcag gccgcatcca caaaggagtt 
                 1560 
               
               
                   
               
               
                 tgttcaactt ggatgaagaa cgcagtgcct atgaccgaga gtcaagattg cagttgggcc 
                 1620 
               
               
                   
               
               
                 ccaatatacg tccgaacatc caatttcaga ctaccatctg accctaaggt cccggttatc 
                 1680 
               
               
                   
               
               
                 atgattggac ctggcactgg tttggctcct tttagaggtt tccttcaaga gcggttagct 
                 1740 
               
               
                   
               
               
                 ttaaaggaag ccggaactga cctcggttta tccattttat tcttcggatg taggaatcgc 
                 1800 
               
               
                   
               
               
                 aaagtggatt tcatatatga aaacgagctt aacaactttg tggagactgg tgctctttct 
                 1860 
               
               
                   
               
               
                 gagcttattg ttgctttctc ccgtgaaggc ccgactaagg aatatgtgca acacaagatg 
                 1920 
               
               
                   
               
               
                 agtgagaagg cttcggatat ctggaacttg ctttctgaag gagcatattt atacgtatgt 
                 1980 
               
               
                   
               
               
                 ggtgatgcca aaggcatggc caaagatgta catcgaaccc tccacacaat tgtgcaagaa 
                 2040 
               
               
                   
               
               
                 cagggatctc ttgactcgtc aaaggcagaa ctctacgtga agaatctaca aatgtcagga 
                 2100 
               
               
                   
               
               
                 agatacctcc gtgacgtttg gtaa 
                 2124 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 86 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MQSNSVKISP LDLVTALFSG KVLDTSNASE SGESAMLPTI AMIMENRELL MILTTSVAVL 
                 60 
               
               
                   
               
               
                 IGCVVVLVWR RSSTKKSALE PPVIVVPKRV QEEEVDDGKK KVTVFFGTQT GTAEGFAKAL 
                 120 
               
               
                   
               
               
                 VEEAKARYEK AVFKVIDLDD YAADDDEYEE KLKKESLAFF FLATYGDGEP TDNAARFYKW 
                 180 
               
               
                   
               
               
                 FTEGDAKGEW LNKLQYGVFG LGNRQYEHFN KIAKVVDDGL VEQGAKRLVP VGLGDDDQCI 
                 240 
               
               
                   
               
               
                 EDDFTAWKEL VWPELDQLLR DEDDTTVATP YTAAVAEYRV VFHEKPDALS EDYSYTNGHA 
                 300 
               
               
                   
               
               
                 VHDAQHPCRS NVAVKKELHS PESDRSCTHL EFDISNTGLS YETGDHVGVY CENLSEVVND 
                 360 
               
               
                   
               
               
                 AERLVGLPPD TYSSIHTDSE DGSPLGGASL PPPFPPCTLR KALTCYADVL SSPKKSALLA 
                 420 
               
               
                   
               
               
                 LAAHATDPSE ADRLKFLASP AGKDEYSQWI VASQRSLLEV MEAFPSAKPS LGVFFASVAP 
                 480 
               
               
                   
               
               
                 RLQPRYYSIS SSPKMAPDRI HVTCALVYEK TPAGRIHKGV CSTWMKNAVP MTESQDCSWA 
                 540 
               
               
                   
               
               
                 PIYVRTSNFR LPSDPKVPVI MIGPGTGLAP FRGFLQERLA LKEAGTDLGL SILFFGCRNR 
                 600 
               
               
                   
               
               
                 KVDFIYENEL NNFVETGALS ELIVAFSREG PTKEYVQHKM SEKASDIWNL LSEGAYLYVC 
                 660 
               
               
                   
               
               
                 GDAKGMAKDV HRTLHTIVQE QGSLDSSKAE LYVKNLQMSG RYLRDVW 
                 707 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 87 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgtcctcca actccgattt ggtcagaaga ttggaatctg ttttgggtgt ttctttcggt 
                 60 
               
               
                   
               
               
                 ggttctgtta ctgattccgt tgttgttatt gctaccacct ctattgcttt ggttatcggt 
                 120 
               
               
                   
               
               
                 gttttggttt tgttgtggag aagatcctct gacagatcta gagaagttaa gcaattggct 
                 180 
               
               
                   
               
               
                 gttccaaagc cagttactat cgttgaagaa gaagatgaat tcgaagttgc ttctggtaag 
                 240 
               
               
                   
               
               
                 accagagttt ctattttcta cggtactcaa actggtactg ctgaaggttt tgctaaggct 
                 300 
               
               
                   
               
               
                 ttggctgaag aaatcaaagc cagatacgaa aaagctgccg ttaaggttat tgatttggat 
                 360 
               
               
                   
               
               
                 gattacacag ccgaagatga caaatacggt gaaaagttga agaaagaaac tatggccttc 
                 420 
               
               
                   
               
               
                 ttcatgttgg ctacttatgg tgatggtgaa cctactgata atgctgctag attttacaag 
                 480 
               
               
                   
               
               
                 tggttcaccg aaggtactga tagaggtgtt tggttggaac atttgagata cggtgtattc 
                 540 
               
               
                   
               
               
                 ggtttgggta acagacaata cgaacacttc aacaagattg ccaaggttgt tgatgatttg 
                 600 
               
               
                   
               
               
                 ttggttgaac aaggtgccaa gagattggtt actgttggtt tgggtgatga tgatcaatgc 
                 660 
               
               
                   
               
               
                 atcgaagatg atttctccgc ttggaaagaa gccttgtggc cagaattgga tcaattattg 
                 720 
               
               
                   
               
               
                 caagatgata ccaacaccgt ttctactcca tacactgctg ttattccaga atacagagtt 
                 780 
               
               
                   
               
               
                 gttatccacg atccatctgt tacctcttat gaagatccat actctaacat ggctaacggt 
                 840 
               
               
                   
               
               
                 aatgcctctt acgatattca tcatccatgt agagctaacg ttgccgtcca aaaagaattg 
                 900 
               
               
                   
               
               
                 cataagccag aatctgacag aagttgcatc catttggaat tcgatatttt cgctactggt 
                 960 
               
               
                   
               
               
                 ttgacttacg aaaccggtga tcatgttggt gtttacgctg ataattgtga tgatactgta 
                 1020 
               
               
                   
               
               
                 gaagaagccg ctaagttgtt gggtcaacca ttggatttgt tgttctccat tcataccgat 
                 1080 
               
               
                   
               
               
                 aacaacgacg gtacttcttt gggttcttct ttgccaccac catttccagg tccatgtact 
                 1140 
               
               
                   
               
               
                 ttgagaactg ctttggctag atatgccgat ttgttgaatc caccaaaaaa ggctgctttg 
                 1200 
               
               
                   
               
               
                 attgctttag ctgctcatgc tgatgaacca tctgaagctg aaagattgaa gttcttgtca 
                 1260 
               
               
                   
               
               
                 tctccacaag gtaaggacga atattctaaa tgggttgtcg gttcccaaag atccttggtt 
                 1320 
               
               
                   
               
               
                 gaagttatgg ctgaatttcc atctgctaaa ccaccattgg gtgtattttt tgctgctgtt 
                 1380 
               
               
                   
               
               
                 gttcctagat tgcaacctag atattactcc atctcttcca gtccaagatt tgctccacat 
                 1440 
               
               
                   
               
               
                 agagttcatg ttacttgcgc tttggtttat ggtccaactc caactggtag aattcacaga 
                 1500 
               
               
                   
               
               
                 ggtgtatgtt cattctggat gaagaatgtt gtcccattgg aaaagtctca aaactgttct 
                 1560 
               
               
                   
               
               
                 tgggccccaa ttttcatcag acaatctaat ttcaagttgc cagccgatca ttctgttcca 
                 1620 
               
               
                   
               
               
                 atagttatgg ttggtccagg tactggttta gctcctttta gaggtttctt acaagaaaga 
                 1680 
               
               
                   
               
               
                 ttggccttga aagaagaagg tgctcaagtt ggtcctgctt tgttgttttt tggttgcaga 
                 1740 
               
               
                   
               
               
                 aacagacaaa tggacttcat ctacgaagtc gaattgaaca actttgtcga acaaggtgct 
                 1800 
               
               
                   
               
               
                 ttgtccgaat tgatcgttgc tttttcaaga gaaggtccat ccaaagaata cgtccaacat 
                 1860 
               
               
                   
               
               
                 aagatggttg aaaaggcagc ttacatgtgg aacttgattt ctcaaggtgg ttacttctac 
                 1920 
               
               
                   
               
               
                 gtttgtggtg atgctaaagg tatggctaga gatgttcata gaacattgca taccatcgtc 
                 1980 
               
               
                   
               
               
                 caacaagaag aaaaggttga ttctaccaag gccgaatcca tcgttaagaa attgcaaatg 
                 2040 
               
               
                   
               
               
                 gacggtagat acttgagaga tgtttggtga 
                 2070 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 88 
               
               
                 R. suavissimus 
               
            
           
           
               
               
            
               
                 MSSNSDLVRR LESVLGVSFG GSVTDSVVVI ATTSIALVIG VLVLLWRRSS DRSREVKQLA 
                 60 
               
               
                   
               
               
                 VPKPVTIVEE EDEFEVASGK TRVSIFYGTQ TGTAEGFAKA LAEEIKARYE KAAVKVIDLD 
                 120 
               
               
                   
               
               
                 DYTAEDDKYG EKLKKETMAF FMLATYGDGE PTDNAARFYK WFTEGTDRGV WLEHLRYGVF 
                 180 
               
               
                   
               
               
                 GLGNRQYEHF NKIAKVVDDL LVEQGAKRLV TVGLGDDDQC IEDDFSAWKE ALWPELDQLL 
                 240 
               
               
                   
               
               
                 QDDTNTVSTP YTAVIPEYRV VIHDPSVTSY EDPYSNMANG NASYDIHHPC RANVAVQKEL 
                 300 
               
               
                   
               
               
                 HKPESDRSCI HLEFDIFATG LTYETGDHVG VYADNCDDTV EEAAKLLGQP LDLLFSIHTD 
                 360 
               
               
                   
               
               
                 NNDGTSLGSS LPPPFPGPCT LRTALARYAD LLNPPKKAAL IALAAHADEP SEAERLKFLS 
                 420 
               
               
                   
               
               
                 SPQGKDEYSK WVVGSQRSLV EVMAEFPSAK PPLGVFFAAV VPRLQPRYYS ISSSPRFAPH 
                 480 
               
               
                   
               
               
                 RVHVTCALVY GPTPTGRIHR GVCSFWMKNV VPLEKSQNCS WAPIFIRQSN FKLPADHSVP 
                 540 
               
               
                   
               
               
                 IVMVGPGTGL APFRGFLQER LALKEEGAQV GPALLFFGCR NRQMDFIYEV ELNNFVEQGA 
                 600 
               
               
                   
               
               
                 LSELIVAFSR EGPSKEYVQH KMVEKAAYMW NLISQGGYFY VCGDAKGMAR DVHRTLHTIV 
                 660 
               
               
                   
               
               
                 QQEEKVDSTK AESIVKKLQM DGRYLRDVW 
                 689 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 89 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgacttctg cactttatgc ctccgatctt ttcaaacaat tgaaaagtat catgggaacg 
                 60 
               
               
                   
               
               
                 gattctttgt ccgatgatgt tgtattagtt attgctacaa cttctctggc actggttgct 
                 120 
               
               
                   
               
               
                 ggtttcgttg tcttattgtg gaaaaagacc acggcagatc gttccggcga gctaaagcca 
                 180 
               
               
                   
               
               
                 ctaatgatcc ctaagtctct gatggcgaaa gatgaggatg atgacttaga tctaggttct 
                 240 
               
               
                   
               
               
                 ggaaaaacga gagtctctat cttcttcggc acacaaaccg gaacagccga aggattcgct 
                 300 
               
               
                   
               
               
                 aaagcacttt cagaagagat caaagcaaga tacgaaaagg cggctgtaaa agtaatcgat 
                 360 
               
               
                   
               
               
                 ttggatgatt acgctgccga tgatgaccaa tatgaggaaa agttgaaaaa ggaaacattg 
                 420 
               
               
                   
               
               
                 gctttctttt gtgtagccac gtatggtgat ggtgaaccaa ccgataacgc cgcaagattc 
                 480 
               
               
                   
               
               
                 tacaagtggt ttactgaaga gaacgaaaga gatatcaagt tgcagcaact tgcttacggc 
                 540 
               
               
                   
               
               
                 gtttttgcct taggtaacag acaatacgag cactttaaca agataggtat tgtcttagat 
                 600 
               
               
                   
               
               
                 gaagagttat gcaaaaaggg tgcgaagaga ttgattgaag tcggtttagg agatgatgat 
                 660 
               
               
                   
               
               
                 caatctatcg aggatgactt taatgcatgg aaggaatctt tgtggtctga attagataag 
                 720 
               
               
                   
               
               
                 ttacttaagg acgaagatga taaatccgtt gccactccat acacagccgt cattccagaa 
                 780 
               
               
                   
               
               
                 tatagagtag ttactcatga tccaagattc acaacacaga aatcaatgga aagtaatgtg 
                 840 
               
               
                   
               
               
                 gctaatggta atactaccat cgatattcat catccatgta gagtagacgt tgcagttcaa 
                 900 
               
               
                   
               
               
                 aaggaattgc acactcatga atcagacaga tcttgcatac atcttgaatt tgatatatca 
                 960 
               
               
                   
               
               
                 cgtactggta tcacttacga aacaggtgat cacgtgggtg tctacgctga aaaccatgtt 
                 1020 
               
               
                   
               
               
                 gaaattgtag aggaagctgg aaagttgttg ggccatagtt tagatcttgt tttctcaatt 
                 1080 
               
               
                   
               
               
                 catgccgata aagaggatgg ctcaccacta gaaagtgcag tgcctccacc atttccagga 
                 1140 
               
               
                   
               
               
                 ccatgcaccc taggtaccgg tttagctcgt tacgcggatc tgttaaatcc tccacgtaaa 
                 1200 
               
               
                   
               
               
                 tcagctctag tggccttggc tgcgtacgcc acagaacctt ctgaggcaga aaaactgaaa 
                 1260 
               
               
                   
               
               
                 catctaactt caccagatgg taaggatgaa tactcacaat ggatagtagc tagtcaacgt 
                 1320 
               
               
                   
               
               
                 tctttactag aagttatggc tgctttccca tccgctaaac ctcctttggg tgttttcttc 
                 1380 
               
               
                   
               
               
                 gccgcaatag cgcctagact gcaaccaaga tactattcaa tttcatcctc acctagactg 
                 1440 
               
               
                   
               
               
                 gcaccatcaa gagttcatgt cacatccgct ttagtgtacg gtccaactcc tactggtaga 
                 1500 
               
               
                   
               
               
                 atccataagg gcgtttgttc aacatggatg aaaaacgcgg ttccagcaga gaagtctcac 
                 1560 
               
               
                   
               
               
                 gaatgttctg gtgctccaat ctttatcaga gcctccaact tcaaactgcc ttccaatcct 
                 1620 
               
               
                   
               
               
                 tctactccta ttgtcatggt cggtcctggt acaggtcttg ctccattcag aggtttctta 
                 1680 
               
               
                   
               
               
                 caagagagaa tggccttaaa ggaggatggt gaagagttgg gatcttcttt gttgtttttc 
                 1740 
               
               
                   
               
               
                 ggctgtagaa acagacaaat ggatttcatc tacgaagatg aactgaataa ctttgtagat 
                 1800 
               
               
                   
               
               
                 caaggagtta tttcagagtt gataatggct ttttctagag aaggtgctca gaaggagtac 
                 1860 
               
               
                   
               
               
                 gtccaacaca aaatgatgga aaaggccgca caagtttggg acttaatcaa agaggaaggc 
                 1920 
               
               
                   
               
               
                 tatctatatg tctgtggtga tgcaaagggt atggcaagag atgttcacag aacacttcat 
                 1980 
               
               
                   
               
               
                 actatagtcc aggaacagga aggcgttagt tcttctgaag cggaagcaat tgtgaaaaag 
                 2040 
               
               
                   
               
               
                 ttacaaacag agggaagata cttgagagat gtgtggtaa 
                 2079 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 90 
               
               
                 
                   A. thaliana 
                 
               
            
           
           
               
               
            
               
                 MTSALYASDL FKQLKSIMGT DSLSDDVVLV IATTSLALVA GFVVLLWKKT TADRSGELKP 
                 60 
               
               
                   
               
               
                 LMIPKSLMAK DEDDDLDLGS GKTRVSIFFG TQTGTAEGFA KALSEEIKAR YEKAAVKVID 
                 120 
               
               
                   
               
               
                 LDDYAADDDQ YEEKLKKETL AFFCVATYGD GEPTDNAARF YKWFTEENER DIKLQQLAYG 
                 180 
               
               
                   
               
               
                 VFALGNRQYE HFNKIGIVLD EELCKKGAKR LIEVGLGDDD QSIEDDFNAW KESLWSELDK 
                 240 
               
               
                   
               
               
                 LLKDEDDKSV ATPYTAVIPE YRVVTHDPRF TTQKSMESNV ANGNTTIDIH HPCRVDVAVQ 
                 300 
               
               
                   
               
               
                 KELHTHESDR SCIHLEFDIS RTGITYETGD HVGVYAENHV EIVEEAGKLL GHSLDLVFSI 
                 360 
               
               
                   
               
               
                 HADKEDGSPL ESAVPPPFPG PCTLGTGLAR YADLLNPPRK SALVALAAYA TEPSEAEKLK 
                 420 
               
               
                   
               
               
                 HLTSPDGKDE YSQWIVASQR SLLEVMAAFP SAKPPLGVFF AAIAPRLQPR YYSISSSPRL 
                 480 
               
               
                   
               
               
                 APSRVHVTSA LVYGPTPTGR IHKGVCSTWM KNAVPAEKSH ECSGAPIFIR ASNFKLPSNP 
                 540 
               
               
                   
               
               
                 STPIVMVGPG TGLAPFRGFL QERMALKEDG EELGSSLLFF GCRNRQMDFI YEDELNNFVD 
                 600 
               
               
                   
               
               
                 QGVISELIMA FSREGAQKEY VQHKMMEKAA QVWDLIKEEG YLYVCGDAKG MARDVHRTLH 
                 660 
               
               
                   
               
               
                 TIVQEQEGVS SSEAEAIVKK LQTEGRYLRD VW 
                 692 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 91 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgtcttcct cttcctcttc cagtacctct atgattgatt tgatggctgc tattattaaa 
                 60 
               
               
                   
               
               
                 ggtgaaccag ttatcgtctc cgacccagca aatgcctctg cttatgaatc agttgctgca 
                 120 
               
               
                   
               
               
                 gaattgtctt caatgttgat cgaaaacaga caattcgcca tgatcgtaac tacatcaatc 
                 180 
               
               
                   
               
               
                 gctgttttga tcggttgtat tgtcatgttg gtatggagaa gatccggtag tggtaattct 
                 240 
               
               
                   
               
               
                 aaaagagtcg aacctttgaa accattagta attaagccaa gagaagaaga aatagatgac 
                 300 
               
               
                   
               
               
                 ggtagaaaga aagttacaat atttttcggt acccaaactg gtacagctga aggttttgca 
                 360 
               
               
                   
               
               
                 aaagccttag gtgaagaagc taaggcaaga tacgaaaaga ctagattcaa gatagtcgat 
                 420 
               
               
                   
               
               
                 ttggatgact atgccgctga tgacgatgaa tacgaagaaa agttgaagaa agaagatgtt 
                 480 
               
               
                   
               
               
                 gcatttttct ttttggcaac ctatggtgac ggtgaaccaa ctgacaatgc agccagattc 
                 540 
               
               
                   
               
               
                 tacaaatggt ttacagaggg taatgatcgt ggtgaatggt tgaaaaactt aaagtacggt 
                 600 
               
               
                   
               
               
                 gttttcggtt tgggtaacag acaatacgaa catttcaaca aagttgcaaa ggttgtcgac 
                 660 
               
               
                   
               
               
                 gatattttgg tcgaacaagg tgctcaaaga ttagtccaag taggtttggg tgacgatgac 
                 720 
               
               
                   
               
               
                 caatgtatag aagatgactt tactgcctgg agagaagctt tgtggcctga attagacaca 
                 780 
               
               
                   
               
               
                 atcttgagag aagaaggtga caccgccgtt gctaccccat atactgctgc agtattagaa 
                 840 
               
               
                   
               
               
                 tacagagttt ccatccatga tagtgaagac gcaaagttta atgatatcac tttggccaat 
                 900 
               
               
                   
               
               
                 ggtaacggtt atacagtttt cgatgcacaa cacccttaca aagctaacgt tgcagtcaag 
                 960 
               
               
                   
               
               
                 agagaattac atacaccaga atccgacaga agttgtatac acttggaatt tgatatcgct 
                 1020 
               
               
                   
               
               
                 ggttccggtt taaccatgaa gttgggtgac catgtaggtg ttttatgcga caatttgtct 
                 1080 
               
               
                   
               
               
                 gaaactgttg atgaagcatt gagattgttg gatatgtccc ctgacactta ttttagtttg 
                 1140 
               
               
                   
               
               
                 cacgctgaaa aagaagatgg tacaccaatt tccagttctt taccacctcc attccctcca 
                 1200 
               
               
                   
               
               
                 tgtaacttaa gaacagcctt gaccagatac gcttgcttgt tatcatcccc taaaaagtcc 
                 1260 
               
               
                   
               
               
                 gccttggttg ctttagccgc tcatgctagt gatcctactg aagcagaaag attgaaacac 
                 1320 
               
               
                   
               
               
                 ttagcatctc cagccggtaa agatgaatat tcaaagtggg tagttgaatc tcaaagatca 
                 1380 
               
               
                   
               
               
                 ttgttagaag ttatggcaga atttccatct gccaagcctc cattaggtgt cttctttgct 
                 1440 
               
               
                   
               
               
                 ggtgtagcac ctagattgca accaagattc tactcaatca gttcttcacc taagatcgct 
                 1500 
               
               
                   
               
               
                 gaaactagaa ttcatgttac atgtgcatta gtctacgaaa agatgccaac cggtagaatt 
                 1560 
               
               
                   
               
               
                 cacaagggtg tatgctctac ttggatgaaa aatgctgttc cttacgaaaa atcagaaaag 
                 1620 
               
               
                   
               
               
                 ttgttcttag gtagaccaat cttcgtaaga caatcaaact tcaagttgcc ttctgattca 
                 1680 
               
               
                   
               
               
                 aaggttccaa taatcatgat aggtcctggt acaggtttag ccccattcag aggtttcttg 
                 1740 
               
               
                   
               
               
                 caagaaagat tggctttagt tgaatctggt gtcgaattag gtccttcagt tttgttcttt 
                 1800 
               
               
                   
               
               
                 ggttgtagaa acagaagaat ggatttcatc tatgaagaag aattgcaaag attcgtcgaa 
                 1860 
               
               
                   
               
               
                 tctggtgcat tggccgaatt atctgtagct ttttcaagag aaggtccaac taaggaatac 
                 1920 
               
               
                   
               
               
                 gttcaacata agatgatgga taaggcatcc gacatatgga acatgatcag tcaaggtgct 
                 1980 
               
               
                   
               
               
                 tatttgtacg tttgcggtga cgcaaagggt atggccagag atgtccatag atctttgcac 
                 2040 
               
               
                   
               
               
                 acaattgctc aagaacaagg ttccatggat agtaccaaag ctgaaggttt cgtaaagaac 
                 2100 
               
               
                   
               
               
                 ttacaaactt ccggtagata cttgagagat gtctggtga 
                 2139 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 92 
               
               
                 
                   A. thaliana 
                 
               
            
           
           
               
               
            
               
                 MSSSSSSSTS MIDLMAAIIK GEPVIVSDPA NASAYESVAA ELSSMLIENR QFAMIVTTSI 
                 60 
               
               
                   
               
               
                 AVLIGCIVML VWRRSGSGNS KRVEPLKPLV IKPREEEIDD GRKKVTIFFG TQTGTAEGFA 
                 120 
               
               
                   
               
               
                 KALGEEAKAR YEKTRFKIVD LDDYAADDDE YEEKLKKEDV AFFFLATYGD GEPTDNAARF 
                 180 
               
               
                   
               
               
                 YKWFTEGNDR GEWLKNLKYG VFGLGNRQYE HFNKVAKVVD DILVEQGAQR LVQVGLGDDD 
                 240 
               
               
                   
               
               
                 QCIEDDFTAW REALWPELDT ILREEGDTAV ATPYTAAVLE YRVSIHDSED AKFNDITLAN 
                 300 
               
               
                   
               
               
                 GNGYTVFDAQ HPYKANVAVK RELHTPESDR SCIHLEFDIA GSGLTMKLGD HVGVLCDNLS 
                 360 
               
               
                   
               
               
                 ETVDEALRLL DMSPDTYFSL HAEKEDGTPI SSSLPPPFPP CNLRTALTRY ACLLSSPKKS 
                 420 
               
               
                   
               
               
                 ALVALAAHAS DPTEAERLKH LASPAGKDEY SKWVVESQRS LLEVMAEFPS AKPPLGVFFA 
                 480 
               
               
                   
               
               
                 GVAPRLQPRF YSISSSPKIA ETRIHVTCAL VYEKMPTGRI HKGVCSTWMK NAVPYEKSEK 
                 540 
               
               
                   
               
               
                 LFLGRPIFVR QSNFKLPSDS KVPIIMIGPG TGLAPFRGFL QERLALVESG VELGPSVLFF 
                 600 
               
               
                   
               
               
                 GCRNRRMDFI YEEELQRFVE SGALAELSVA FSREGPTKEY VQHKMMDKAS DIWNMISQGA 
                 660 
               
               
                   
               
               
                 YLYVCGDAKG MARDVHRSLH TIAQEQGSMD STKAEGFVKN LQTSGRYLRD VW 
                 712 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 93 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggaagcct cttacctata catttctatt ttgcttttac tggcatcata cctgttcacc 
                 60 
               
               
                   
               
               
                 actcaactta gaaggaagag cgctaatcta ccaccaaccg tgtttccatc aataccaatc 
                 120 
               
               
                   
               
               
                 attggacact tatacttact caaaaagcct ctttatagaa ctttagcaaa aattgccgct 
                 180 
               
               
                   
               
               
                 aagtacggac caatactgca attacaactc ggctacagac gtgttctggt gatttcctca 
                 240 
               
               
                   
               
               
                 ccatcagcag cagaagagtg ctttaccaat aacgatgtaa tcttcgcaaa tagacctaag 
                 300 
               
               
                   
               
               
                 acattgtttg gcaaaatagt gggtggaaca tcccttggca gtttatccta cggcgatcaa 
                 360 
               
               
                   
               
               
                 tggcgtaatc taaggagagt agcttctatc gaaatcctat cagttcatag gttgaacgaa 
                 420 
               
               
                   
               
               
                 tttcatgata tcagagtgga tgagaacaga ttgttaatta gaaaacttag aagttcatct 
                 480 
               
               
                   
               
               
                 tctcctgtta ctcttataac agtcttttat gctctaacat tgaacgtcat tatgagaatg 
                 540 
               
               
                   
               
               
                 atctctggca aaagatattt cgacagtggg gatagagaat tggaggagga aggtaagaga 
                 600 
               
               
                   
               
               
                 tttcgagaaa tcttagacga aacgttgctt ctagccggtg cttctaatgt tggcgactac 
                 660 
               
               
                   
               
               
                 ttaccaatat tgaactggtt gggagttaag tctcttgaaa agaaattgat cgctttgcag 
                 720 
               
               
                   
               
               
                 aaaaagagag atgacttttt ccagggtttg attgaacagg ttagaaaatc tcgtggtgct 
                 780 
               
               
                   
               
               
                 aaagtaggca aaggtagaaa aacgatgatc gaactcttat tatctttgca agagtcagaa 
                 840 
               
               
                   
               
               
                 cctgagtact atacagatgc tatgataaga tcttttgtcc taggtctgct ggctgcaggt 
                 900 
               
               
                   
               
               
                 agtgatactt cagcgggcac tatggaatgg gccatgagct tactggtcaa tcacccacat 
                 960 
               
               
                   
               
               
                 gtattgaaga aagctcaagc tgaaatcgat agagttatcg gtaataacag attgattgac 
                 1020 
               
               
                   
               
               
                 gagtcagaca ttggaaatat cccttacatc gggtgtatta tcaatgaaac tctaagactc 
                 1080 
               
               
                   
               
               
                 tatccagcag ggccattgtt gttcccacat gaaagttctg ccgactgcgt tatttccggt 
                 1140 
               
               
                   
               
               
                 tacaatatac ctagaggtac aatgttaatc gtaaaccaat gggcgattca tcacgatcct 
                 1200 
               
               
                   
               
               
                 aaagtctggg atgatcctga aacctttaaa cctgaaagat ttcaaggatt agaaggaact 
                 1260 
               
               
                   
               
               
                 agagatggtt tcaaacttat gccattcggt tctgggagaa gaggatgtcc aggtgaaggt 
                 1320 
               
               
                   
               
               
                 ttggcaataa ggctgttagg gatgacacta ggctcagtga tccaatgttt tgattgggag 
                 1380 
               
               
                   
               
               
                 agagtaggag atgagatggt tgacatgaca gaaggtttgg gtgtcacact tcctaaggcc 
                 1440 
               
               
                   
               
               
                 gttccattag ttgccaaatg taagccacgt tccgaaatga ctaatctcct atccgaactt 
                 1500 
               
               
                   
               
               
                 taa 
                 1503 
               
               
                   
               
               
                 SEQ ID NO: 94 
                   
               
               
                 
                   S. rebaudiana 
                 
                   
               
               
                 MEASYLYISI LLLLASYLFT TQLRRKSANL PPTVFPSIPI IGHLYLLKKP LYRTLAKIAA 
                 60 
               
               
                   
               
               
                 KYGPILQLQL GYRRVLVISS PSAAEECFTN NDVIFANRPK TLFGKIVGGT SLGSLSYGDQ 
                 120 
               
               
                   
               
               
                 WRNLRRVASI EILSVHRLNE FHDIRVDENR LLIRKLRSSS SPVTLITVFY ALTLNVIMRM 
                 180 
               
               
                   
               
               
                 ISGKRYFDSG DRELEEEGKR FREILDETLL LAGASNVGDY LPILNWLGVK SLEKKLIALQ 
                 240 
               
               
                   
               
               
                 KKRDDFFQGL IEQVRKSRGA KVGKGRKTMI ELLLSLQESE PEYYTDAMIR SFVLGLLAAG 
                 300 
               
               
                   
               
               
                 SDTSAGTMEW AMSLLVNHPH VLKKAQAEID RVIGNNRLID ESDIGNIPYI GCIINETLRL 
                 360 
               
               
                   
               
               
                 YPAGPLLFPH ESSADCVISG YNIPRGTMLI VNQWAIHHDP KVWDDPETFK PERFQGLEGT 
                 420 
               
               
                   
               
               
                 RDGFKLMPFG SGRRGCPGEG LAIRLLGMTL GSVIQCFDWE RVGDEMVDMT EGLGVTLPKA 
                 480 
               
               
                   
               
               
                 VPLVAKCKPR SEMTNLLSEL 
                 500 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 95 
               
               
                 
                   R. suavissimus 
                 
               
            
           
           
               
               
            
               
                 atggaagtaa cagtagctag tagtgtagcc ctgagcctgg tctttattag catagtagta 
                 60 
               
               
                   
               
               
                 agatgggcat ggagtgtggt gaattgggtg tggtttaagc cgaagaagct ggaaagattt 
                 120 
               
               
                   
               
               
                 ttgagggagc aaggccttaa aggcaattcc tacaggtttt tatatggaga catgaaggag 
                 180 
               
               
                   
               
               
                 aactctatcc tgctcaaaca agcaagatcc aaacccatga acctctccac ctcccatgac 
                 240 
               
               
                   
               
               
                 atagcacctc aagtcacccc ttttgtcgac caaaccgtga aagcttacgg taagaactct 
                 300 
               
               
                   
               
               
                 tttaattggg ttggccccat accaagggtg aacataatga atccagaaga tttgaaggac 
                 360 
               
               
                   
               
               
                 gtcttaacaa aaaatgttga ctttgttaag ccaatatcaa acccacttat caagttgcta 
                 420 
               
               
                   
               
               
                 gctacaggta ttgcaatcta tgaaggtgag aaatggacta aacacagaag gattatcaac 
                 480 
               
               
                   
               
               
                 ccaacattcc attcggagag gctaaagcgt atgttacctt catttcacca aagttgtaat 
                 540 
               
               
                   
               
               
                 gagatggtca aggaatggga gagcttggtg tcaaaagagg gttcatcatg tgagttggat 
                 600 
               
               
                   
               
               
                 gtctggcctt ttcttgaaaa tatgtcggca gatgtgatct cgagaacagc atttggaact 
                 660 
               
               
                   
               
               
                 agctacaaaa aaggacagaa aatctttgaa ctcttgagag agcaagtaat atatgtaacg 
                 720 
               
               
                   
               
               
                 aaaggctttc aaagttttta cattccagga tggaggtttc tcccaactaa gatgaacaag 
                 780 
               
               
                   
               
               
                 aggatgaatg agattaacga agaaataaaa ggattaatca ggggtattat aattgacaga 
                 840 
               
               
                   
               
               
                 gagcaaatca ttaaggcagg tgaagaaacc aacgatgact tattaggtgc acttatggag 
                 900 
               
               
                   
               
               
                 tcaaacttga aggacattcg ggaacatggg aaaaacaaca aaaatgttgg gatgagtatt 
                 960 
               
               
                   
               
               
                 gaagatgtaa ttcaggagtg taagctgttt tactttgctg ggcaagaaac cacttcagtg 
                 1020 
               
               
                   
               
               
                 ttgctggctt ggacaatggt tttacttggt caaaatcaga actggcaaga tcgagcaaga 
                 1080 
               
               
                   
               
               
                 caagaggttt tgcaagtctt tggaagcagc aagccagatt ttgatggtct agctcacctt 
                 1140 
               
               
                   
               
               
                 aaagtcgtaa ccatgatttt gcttgaagtt cttcgattat acccaccagt cattgaactt 
                 1200 
               
               
                   
               
               
                 attcgaacca ttcacaagaa aacacaactt gggaagctct cactaccaga aggagttgaa 
                 1260 
               
               
                   
               
               
                 gtccgcttac caacactgct cattcaccat gacaaggaac tgtggggtga tgatgcaaac 
                 1320 
               
               
                   
               
               
                 cagttcaatc cagagaggtt ttcggaagga gtttccaaag caacaaagaa ccgactctca 
                 1380 
               
               
                   
               
               
                 ttcttcccct tcggagccgg tccacgcatt tgcattggac agaacttttc tatgatggaa 
                 1440 
               
               
                   
               
               
                 gcaaagttgg ccttagcatt gatcttgcaa cacttcacct ttgagctttc tccatctcat 
                 1500 
               
               
                   
               
               
                 gcacatgctc cttcccatcg tataaccctt caaccacagt atggtgttcg tatcatttta 
                 1560 
               
               
                   
               
               
                 catcgacgtt ag 
                 1572 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 96 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggaagtca ctgtcgcctc ttctgtcgct ttatccttag tcttcatttc cattgtcgtc 
                 60 
               
               
                   
               
               
                 agatgggctt ggtccgttgt caactgggtt tggttcaaac caaagaagtt ggaaagattc 
                 120 
               
               
                   
               
               
                 ttgagagagc aaggtttgaa gggtaattct tatagattct tgtacggtga catgaaggaa 
                 180 
               
               
                   
               
               
                 aattctattt tgttgaagca agccagatcc aaaccaatga acttgtctac ctctcatgat 
                 240 
               
               
                   
               
               
                 attgctccac aagttactcc attcgtcgat caaactgtta aagcctacgg taagaactct 
                 300 
               
               
                   
               
               
                 ttcaattggg ttggtccaat tcctagagtt aacatcatga acccagaaga tttgaaggat 
                 360 
               
               
                   
               
               
                 gtcttgacca agaacgttga cttcgttaag ccaatttcca acccattgat taaattgttg 
                 420 
               
               
                   
               
               
                 gctactggta ttgccattta cgaaggtgaa aagtggacta agcatagaag aatcatcaac 
                 480 
               
               
                   
               
               
                 cctaccttcc actctgaaag attgaagaga atgttaccat ctttccatca atcctgtaat 
                 540 
               
               
                   
               
               
                 gaaatggtta aggaatggga atccttggtt tctaaagaag gttcttcttg cgaattggat 
                 600 
               
               
                   
               
               
                 gtttggccat tcttggaaaa tatgtctgct gatgtcattt ccagaaccgc tttcggtacc 
                 660 
               
               
                   
               
               
                 tcctacaaga agggtcaaaa gattttcgaa ttgttgagag agcaagttat ttacgttacc 
                 720 
               
               
                   
               
               
                 aagggtttcc aatccttcta catcccaggt tggagattct tgccaactaa aatgaacaag 
                 780 
               
               
                   
               
               
                 cgtatgaacg agatcaacga agaaattaaa ggtttgatca gaggtattat tatcgacaga 
                 840 
               
               
                   
               
               
                 gaacaaatta ttaaagctgg tgaagaaacc aacgatgatt tgttgggtgc tttgatggag 
                 900 
               
               
                   
               
               
                 tccaacttga aggatattag agaacatggt aagaacaaca agaatgttgg tatgtctatt 
                 960 
               
               
                   
               
               
                 gaagatgtta ttcaagaatg taagttattc tacttcgctg gtcaagagac cacttctgtt 
                 1020 
               
               
                   
               
               
                 ttgttagcct ggactatggt cttgttaggt caaaaccaaa attggcaaga tagagctaga 
                 1080 
               
               
                   
               
               
                 caagaagttt tgcaagtctt cggttcttcc aagccagact ttgatggttt ggcccacttg 
                 1140 
               
               
                   
               
               
                 aaggttgtta ctatgatttt gttagaagtt ttgagattgt acccaccagt cattgagtta 
                 1200 
               
               
                   
               
               
                 atcagaacca ttcataaaaa gactcaattg ggtaaattat ctttgccaga aggtgttgaa 
                 1260 
               
               
                   
               
               
                 gtcagattac caaccttgtt gattcaccac gataaggaat tatggggtga cgacgctaat 
                 1320 
               
               
                   
               
               
                 caatttaatc cagaaagatt ttccgaaggt gtttccaagg ctaccaaaaa ccgtttgtcc 
                 1380 
               
               
                   
               
               
                 ttcttcccat ttggtgctgg tccacgtatt tgtatcggtc aaaacttttc catgatggaa 
                 1440 
               
               
                   
               
               
                 gccaagttgg ctttggcttt aatcttgcaa cacttcactt tcgaattgtc tccatcccat 
                 1500 
               
               
                   
               
               
                 gcccacgctc cttctcatag aatcacttta caaccacaat acggtgtcag aatcatctta 
                 1560 
               
               
                   
               
               
                 cacagaagat aa 
                 1572 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 97 
               
               
                 
                   R. suavissimus 
                 
               
            
           
           
               
               
            
               
                 MEVTVASSVA LSLVFISIVV RWAWSVVNWV WFKPKKLERF LREQGLKGNS YRFLYGDMKE 
                 60 
               
               
                   
               
               
                 NSILLKQARS KPMNLSTSHD IAPQVTPFVD QTVKAYGKNS FNWVGPIPRV NIMNPEDLKD 
                 120 
               
               
                   
               
               
                 VLTKNVDFVK PISNPLIKLL ATGIAIYEGE KWTKHRRIIN PTFHSERLKR MLPSFHQSCN 
                 180 
               
               
                   
               
               
                 EMVKEWESLV SKEGSSCELD VWPFLENMSA DVISRTAFGT SYKKGQKIFE LLREQVIYVT 
                 240 
               
               
                   
               
               
                 KGFQSFYIPG WRFLPTKMNK RMNEINEEIK GLIRGIIIDR EQIIKAGEET NDDLLGALME 
                 300 
               
               
                   
               
               
                 SNLKDIREHG KNNKNVGMSI EDVIQECKLF YFAGQETTSV LLAWTMVLLG QNQNWQDRAR 
                 360 
               
               
                   
               
               
                 QEVLQVFGSS KPDFDGLAHL KVVTMILLEV LRLYPPVIEL IRTIHKKTQL GKLSLPEGVE 
                 420 
               
               
                   
               
               
                 VRLPTLLIHH DKELWGDDAN QFNPERFSEG VSKATKNRLS FFPFGAGPRI CIGQNFSMME 
                 480 
               
               
                   
               
               
                 AKLALALILQ HFTFELSPSH AHAPSHRITL QPQYGVRIIL HRR 
                 523 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 98 
               
               
                 
                   P. avium 
                 
               
            
           
           
               
               
            
               
                 atggaagcat caagggctag ttgtgttgcg ctatgtgttg tttgggtgag catagtaatt 
                 60 
               
               
                   
               
               
                 acattggcat ggagggtgct gaattgggtg tggttgaggc caaagaaact agaaagatgc 
                 120 
               
               
                   
               
               
                 ttgagggagc aaggccttac aggcaattct tacaggcttt tgtttggaga caccaaggat 
                 180 
               
               
                   
               
               
                 ctctcgaaga tgctggaaca aacacaatcc aaacccatca aactctccac ctcccatgat 
                 240 
               
               
                   
               
               
                 atagcgccac gagtcacccc atttttccat cgaactgtga actctaatgg caagaattct 
                 300 
               
               
                   
               
               
                 tttgtttgga tgggccctat accaagagtg cacatcatga atccagaaga tttgaaagat 
                 360 
               
               
                   
               
               
                 gccttcaaca gacatgatga ttttcataag acagtaaaaa atcctatcat gaagtctcca 
                 420 
               
               
                   
               
               
                 ccaccgggca ttgtaggcat tgaaggtgag caatgggcta aacacagaaa gattatcaac 
                 480 
               
               
                   
               
               
                 ccagcattcc atttagagaa gctaaagggt atggtaccaa tattttacca aagttgtagc 
                 540 
               
               
                   
               
               
                 gagatgatta acaaatggga gagcttggtg tccaaagaga gttcatgtga gttggatgtg 
                 600 
               
               
                   
               
               
                 tggccttatc ttgaaaattt taccagcgat gtgatttccc gagctgcatt tggaagtagc 
                 660 
               
               
                   
               
               
                 tatgaagagg gaaggaaaat atttcaacta ctaagagagg aagcaaaagt ttattcggta 
                 720 
               
               
                   
               
               
                 gctctacgaa gtgtttacat tccaggatgg aggtttctac caaccaagca gaacaagaag 
                 780 
               
               
                   
               
               
                 acgaaggaaa ttcacaatga aattaaaggc ttacttaagg gcattataaa taaaagggaa 
                 840 
               
               
                   
               
               
                 gaggcgatga aggcagggga agccactaaa gatgacttac taggaatact tatggagtcc 
                 900 
               
               
                   
               
               
                 aacttcaggg aaattcagga acatgggaac aacaaaaatg ctggaatgag tattgaagat 
                 960 
               
               
                   
               
               
                 gtaattggag agtgtaagtt gttttacttt gctgggcaag agaccacttc ggtgttgctt 
                 1020 
               
               
                   
               
               
                 gtttggacaa tgattttact aagccaaaat caggattggc aagctcgtgc aagagaagag 
                 1080 
               
               
                   
               
               
                 gtcttgaaag tctttggaag caacatccca acctatgaag agctaagtca cctaaaagtt 
                 1140 
               
               
                   
               
               
                 gtgaccatga ttttacttga agttcttcga ttatacccat cagtcgttgc gcttcctcga 
                 1200 
               
               
                   
               
               
                 accactcaca agaaaacaca gcttggaaaa ttatcattac cagctggagt ggaagtctcc 
                 1260 
               
               
                   
               
               
                 ttgcccatac tgcttgttca ccatgacaaa gagttgtggg gtgaggatgc aaatgagttc 
                 1320 
               
               
                   
               
               
                 aagccagaga ggttttcaga gggagtttca aaggcaacaa agaacaaatt tacatactta 
                 1380 
               
               
                   
               
               
                 cctttcggag ggggtccaag gatttgcatt ggacaaaact ttgccatggt ggaagctaaa 
                 1440 
               
               
                   
               
               
                 ttggccttgg ccctgatttt acaacacttt gcctttgagc tttctccatc ctatgctcat 
                 1500 
               
               
                   
               
               
                 gctccttctg cagttataac ccttcaacct caatttggtg ctcatatcat tttgcataaa 
                 1560 
               
               
                   
               
               
                 cgttga 
                 1566 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 99 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggaagctt ctagagcatc ttgtgttgct ttgtgtgttg tttgggtttc catcgttatt 
                 60 
               
               
                   
               
               
                 actttggctt ggagagtttt gaattgggtc tggttaagac caaaaaagtt ggaaagatgc 
                 120 
               
               
                   
               
               
                 ttgagagaac aaggtttgac tggtaactct tacagattgt tgttcggtga taccaaggac 
                 180 
               
               
                   
               
               
                 ttgtctaaga tgttggaaca aactcaatcc aagcctatca agttgtctac ctctcatgat 
                 240 
               
               
                   
               
               
                 attgctccaa gagttactcc attcttccat agaactgtta actccaacgg taagaactct 
                 300 
               
               
                   
               
               
                 tttgtttgga tgggtccaat tccaagagtc catattatga accctgaaga tttgaaggac 
                 360 
               
               
                   
               
               
                 gctttcaaca gacatgatga tttccataag accgtcaaga acccaattat gaagtctcca 
                 420 
               
               
                   
               
               
                 ccaccaggta tagttggtat tgaaggtgaa caatgggcca aacatagaaa gattattaac 
                 480 
               
               
                   
               
               
                 ccagccttcc acttggaaaa gttgaaaggt atggttccaa tcttctacca atcctgctct 
                 540 
               
               
                   
               
               
                 gaaatgatta acaagtggga atccttggtt tccaaagaat cttcctgtga attggatgtc 
                 600 
               
               
                   
               
               
                 tggccatatt tggaaaactt cacctccgat gttatttcca gagctgcttt tggttcttct 
                 660 
               
               
                   
               
               
                 tacgaagaag gtagaaagat cttccaatta ttgagagaag aagccaaggt ttactccgtt 
                 720 
               
               
                   
               
               
                 gctttgagat ctgtttacat tccaggttgg agattcttgc caactaagca aaacaaaaag 
                 780 
               
               
                   
               
               
                 accaaagaaa tccacaacga aatcaagggt ttgttgaagg gtatcatcaa caagagagaa 
                 840 
               
               
                   
               
               
                 gaagctatga aggctggtga agctacaaaa gatgatttgt tgggtatctt gatggaatcc 
                 900 
               
               
                   
               
               
                 aacttcagag aaatccaaga acacggtaac aacaagaatg ccggtatgtc tattgaagat 
                 960 
               
               
                   
               
               
                 gttatcggtg aatgcaagtt gttctacttt gctggtcaag aaactacctc cgttttgttg 
                 1020 
               
               
                   
               
               
                 gtttggacca tgattttgtt gtcccaaaat caagattggc aagctagagc tagagaagaa 
                 1080 
               
               
                   
               
               
                 gtcttgaaag ttttcggttc taacatccca acctacgaag aattgtctca cttgaaggtt 
                 1140 
               
               
                   
               
               
                 gtcactatga tcttgttgga agtattgaga ttatacccat ccgttgttgc attgccaaga 
                 1200 
               
               
                   
               
               
                 actactcata agaaaactca attgggtaaa ttgtccttgc cagctggtgt tgaagtttct 
                 1260 
               
               
                   
               
               
                 ttgccaattt tgttagtcca ccacgacaaa gaattgtggg gtgaagatgc taatgaattc 
                 1320 
               
               
                   
               
               
                 aagccagaaa gattctccga aggtgtttct aaagctacca agaacaagtt cacttacttg 
                 1380 
               
               
                   
               
               
                 ccatttggtg gtggtccaag aatatgtatt ggtcaaaatt tcgctatggt cgaagctaaa 
                 1440 
               
               
                   
               
               
                 ttggctttgg ctttgatctt gcaacatttc gctttcgaat tgtcaccatc ttatgctcat 
                 1500 
               
               
                   
               
               
                 gctccatctg ctgttattac attgcaacca caatttggtg cccatatcat cttgcataag 
                 1560 
               
               
                   
               
               
                 agataac 
                 1567 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 100 
               
               
                 
                   P. avium 
                 
               
            
           
           
               
               
            
               
                 MEASRASCVA LCVVWVSIVI TLAWRVLNWV WLRPKKLERC LREQGLTGNS YRLLFGDTKD 
                 60 
               
               
                   
               
               
                 LSKMLEQTQS KPIKLSTSHD IAPRVTPFFH RTVNSNGKNS FVWMGPIPRV HIMNPEDLKD 
                 120 
               
               
                   
               
               
                 AFNRHDDFHK TVKNPIMKSP PPGIVGIEGE QWAKHRKIIN PAFHLEKLKG MVPIFYQSCS 
                 180 
               
               
                   
               
               
                 EMINKWESLV SKESSCELDV WPYLENFTSD VISRAAFGSS YEEGRKIFQL LREEAKVYSV 
                 240 
               
               
                   
               
               
                 ALRSVYIPGW RFLPTKQNKK TKEIHNEIKG LLKGIINKRE EAMKAGEATK DDLLGILMES 
                 300 
               
               
                   
               
               
                 NFREIQEHGN NKNAGMSIED VIGECKLFYF AGQETTSVLL VWTMILLSQN QDWQARAREE 
                 360 
               
               
                   
               
               
                 VLKVFGSNIP TYEELSHLKV VTMILLEVLR LYPSVVALPR TTHKKTQLGK LSLPAGVEVS 
                 420 
               
               
                   
               
               
                 LPILLVHHDK ELWGEDANEF KPERFSEGVS KATKNKFTYL PFGGGPRICI GQNFAMVEAK 
                 480 
               
               
                   
               
               
                 LALALILQHF AFELSPSYAH APSAVITLQP QFGAHIILHK R 
                 521 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 101 
               
               
                 
                   P. mume 
                 
               
            
           
           
               
               
            
               
                 ASWVAVLSVV WVSMVIAWAW RVLNWVWLRP KKLEKCLREQ GLAGNSYRLL FGDTKDLSKM 
                 60 
               
               
                   
               
               
                 LEQTQSKPIK LSTSHDIAPH VTPFFHQTVN SYGKNSFVWM GPIPRVHIMN PEDLKDTFNR 
                 120 
               
               
                   
               
               
                 HDDFHKVVKN PIMKSLPQGI VGIEGEQWAK HRKIINPAFH LEKLKGMVPI FYRSCSEMIN 
                 180 
               
               
                   
               
               
                 KWESLVSKES SCELDVWPYL ENFTSDVISR AAFGSSYEEG RKIFQLLREE AKIYTVAMRS 
                 240 
               
               
                   
               
               
                 VYIPGWRFLP TKQNKKAKEI HNEIKGLLKG IINKREEAMK AGEATKDDLL GILMESNFRE 
                 300 
               
               
                   
               
               
                 IQEHGNNKNA GMSIEDVIGE CKLFYFAGQE TTSVLLVWTM VLLSQNQDWQ ARAREEVLQV 
                 360 
               
               
                   
               
               
                 FGSNIPTYEE LSQLKVVTMI LLEVLRLYPS VVALPRTTHK KTQLGKLSLP AGVEVSLPIL 
                 420 
               
               
                   
               
               
                 LVHHDKELWG EDANEFKPER FSEGVSKATK NQFTYFPFGG GPRICIGQNF AMMEAKLALS 
                 480 
               
               
                   
               
               
                 LILRHFALEL SPLYAHAPSV TITLQPQYGA HIILHKR 
                 517 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 102 
               
               
                 
                   P. mume 
                 
               
            
           
           
               
               
            
               
                 MEASRPSCVA LSVVLVSIVI AWAWRVLNWV WLRPNKLERC LREQGLTGNS YRLLFGDTKE 
                 60 
               
               
                   
               
               
                 ISMMVEQAQS KPIKLSTTHD IAPRVIPFSH QIVYTYGRNS FVWMGPTPRV TIMNPEDLKD 
                 120 
               
               
                   
               
               
                 AFNKSDEFQR AISNPIVKSI SQGLSSLEGE KWAKHRKIIN PAFHLEKLKG MLPTFYQSCS 
                 180 
               
               
                   
               
               
                 EMINKWESLV FKEGSREMDV WPYLENLTSD VISRAAFGSS YEEGRKIFQL LREEAKFYTI 
                 240 
               
               
                   
               
               
                 AARSVYIPGW RFLPTKQNKR MKEIHKEVRG LLKGIINKRE DAIKAGEAAK GNLLGILMES 
                 300 
               
               
                   
               
               
                 NFREIQEHGN NKNAGMSIED VIGECKLFYF AGQETTSVLL VWTLVLLSQN QDWQARAREE 
                 360 
               
               
                   
               
               
                 VLQVFGTNIP TYDQLSHLKV VTMILLEVLR LYPAVVELPR TTYKKTQLGK FLLPAGVEVS 
                 420 
               
               
                   
               
               
                 LHIMLAHHDK ELWGEDAKEF KPERFSEGVS KATKNQFTYF PFGAGPRICI GQNFAMLEAK 
                 480 
               
               
                   
               
               
                 LALSLILQHF TFELSPSYAH APSVTITLHP QFGAHFILHK R 
                 521 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 103 
               
               
                 
                   P. mume 
                 
               
            
           
           
               
               
            
               
                 CVALSVVLVS IVIAWAWRVL NWVWLRPNKL ERCLREQGLT GNSYRLLFGD TKEISMMVEQ 
                 60 
               
               
                   
               
               
                 AQSKPIKLST THDIAPRVIP FSHQIVYTYG RNSFVWMGPT PRVTIMNPED LKDAFNKSDE 
                 120 
               
               
                   
               
               
                 FQRAISNPIV KSISQGLSSL EGEKWAKHRK IINPAFHLEK LKGMLPTFYQ SCSEMINKWE 
                 180 
               
               
                   
               
               
                 SLVFKEGSRE MDVWPYLENL TSDVISRAAF GSSYEEGRKI FQLLREEAKF YTIAARSVYI 
                 240 
               
               
                   
               
               
                 PGWRFLPTKQ NKRMKEIHKE VRGLLKGIIN KREDAIKAGE AAKGNLLGIL MESNFREIQE 
                 300 
               
               
                   
               
               
                 HGNNKNAGMS IEDVIGECKL FYFAGQETTS VLLVWTLVLL SQNQDWQARA REEVLQVFGT 
                 360 
               
               
                   
               
               
                 NIPTYDQLSH LKVVTMILLE VLRLYPAVVE LPRTTYKKTQ LGKFLLPAGV EVSLHIMLAH 
                 420 
               
               
                   
               
               
                 HDKELWGEDA KEFKPERFSE GVSKATKNQF TYFPFGAGPR ICIGQNFAML EAKLALSLIL 
                 480 
               
               
                   
               
               
                 QHFTFELSPS YAHAPSVTIT LHPQFGAHFI LHKR 
                 514 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 104 
               
               
                 
                   P. persica 
                 
               
            
           
           
               
               
            
               
                 MGPIPRVHIM NPEDLKDTFN RHDDFHKVVK NPIMKSLPQG IVGIEGDQWA KHRKIINPAF 
                 60 
               
               
                   
               
               
                 HLEKLKGMVP IFYQSCSEMI NIWKSLVSKE SSCELDVWPY LENFTSDVIS RAAFGSSYEE 
                 120 
               
               
                   
               
               
                 GRKIFQLLRE EAKVYTVAVR SVYIPGWRFL PTKQNKKTKE IHNEIKGLLK GIINKREEAM 
                 180 
               
               
                   
               
               
                 KAGEATKDDL LGILMESNFR EIQEHGNNKN AGMSIEDVIG ECKLFYFAGQ ETTSVLLVWT 
                 240 
               
               
                   
               
               
                 MVLLSQNQDW QARAREEVLQ VFGSNIPTYE ELSHLKVVTM ILLEVLRLYP SVVALPRTTH 
                 300 
               
               
                   
               
               
                 KKTQLGKLSL PAGVEVSLPI LLVHHDKELW GEDANEFKPE RFSEGVSKAT KNQFTYFPFG 
                 360 
               
               
                   
               
               
                 GGPRICIGQN FAMMEAKLAL SLILQHFTFE LSPQYSHAPS VTITLQPQYG AHLILHKR 
                 418 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 105 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgggtttgt tcccattaga ggattcctac gcgctggtct ttgaaggact agcaataaca 
                 60 
               
               
                   
               
               
                 ctggctttgt actatctact gtctttcatc tacaaaacat ctaaaaagac atgtacacct 
                 120 
               
               
                   
               
               
                 cctaaagcat ctggtgaaat cattccaatt acaggaatca tattgaatct gctatctggc 
                 180 
               
               
                   
               
               
                 tcaagtggtc tacctattat cttagcactt gcctctttag cagacagatg tggtcctatt 
                 240 
               
               
                   
               
               
                 ttcaccatta ggctgggtat taggagagtg ctagtagtat caaattggga aatcgctaag 
                 300 
               
               
                   
               
               
                 gagattttca ctacccacga tttgatagtt tctaatagac caaaatactt agccgctaag 
                 360 
               
               
                   
               
               
                 attcttggtt tcaattatgt ttcattctct ttcgctccat acggcccata ttgggtcgga 
                 420 
               
               
                   
               
               
                 atcagaaaga ttattgctac aaaactaatg tcttcttcca gacttcagaa gttgcaattt 
                 480 
               
               
                   
               
               
                 gtaagagttt ttgaactaga aaactctatg aaatctatca gagaatcatg gaaggagaaa 
                 540 
               
               
                   
               
               
                 aaggatgaag agggaaaggt attagttgag atgaaaaagt ggttctggga actgaatatg 
                 600 
               
               
                   
               
               
                 aacatagtgt taaggacagt tgctggtaaa caatacactg gtacagttga tgatgccgat 
                 660 
               
               
                   
               
               
                 gcaaagcgta tctccgagtt attcagagaa tggtttcact acactggcag atttgtcgtt 
                 720 
               
               
                   
               
               
                 ggagacgctt ttccttttct aggttggttg gacctgggcg gatacaaaaa gacaatggaa 
                 780 
               
               
                   
               
               
                 ttagttgcta gtagattgga ctcaatggtc agtaaatggt tagatgagca tcgtaaaaag 
                 840 
               
               
                   
               
               
                 caagctaacg atgacaaaaa ggaggatatg gatttcatgg atatcatgat ctccatgaca 
                 900 
               
               
                   
               
               
                 gaagcaaatt caccacttga aggatacggc actgatacta ttatcaagac cacatgtatg 
                 960 
               
               
                   
               
               
                 actttgattg tttcaggagt tgatacaacc tcaatcgtac ttacttgggc cttatcactt 
                 1020 
               
               
                   
               
               
                 ttgttaaaca acagagatac tttgaaaaag gcacaagagg aattagatat gtgcgtaggt 
                 1080 
               
               
                   
               
               
                 aaaggaagac aagtcaacga gtctgatctt gttaacttga tatacttgga agcagtgctt 
                 1140 
               
               
                   
               
               
                 aaagaggctt taagacttta cccagcagcg ttcttaggcg gaccaagagc attcttggaa 
                 1200 
               
               
                   
               
               
                 gattgtactg ttgctggtta tagaattcca aagggcacct gcttgttgat taacatgtgg 
                 1260 
               
               
                   
               
               
                 aaactgcata gagatccaaa catttggagt gatccttgcg aattcaagcc agaaagattt 
                 1320 
               
               
                   
               
               
                 ttgacaccta atcaaaagga tgttgatgtg atcggtatgg atttcgaatt gataccattt 
                 1380 
               
               
                   
               
               
                 ggtgccggca gaagatattg tccaggtact agattggctt tacagatgtt gcatatcgta 
                 1440 
               
               
                   
               
               
                 ttagcgacat tgctgcaaaa cttcgaaatg tcaacaccaa acgatgcgcc agtcgatatg 
                 1500 
               
               
                   
               
               
                 actgcttctg ttggcatgac aaatgccaaa gcatcacctt tagaagtctt gctatcacct 
                 1560 
               
               
                   
               
               
                 cgtgttaaat ggtcctaa 
                 1578 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 106 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MGLFPLEDSY ALVFEGLAIT LALYYLLSFI YKTSKKTCTP PKASGEHPIT GHLNLLSGSS 
                 60 
               
               
                   
               
               
                 GLPHLALASL ADRCGPIFTI RLGIRRVLVV SNWEIAKEIF TTHDLIVSNR PKYLAAKILG 
                 120 
               
               
                   
               
               
                 FNYVSFSFAP YGPYWVGIRK IIATKLMSSS RLQKLQFVRV FELENSMKSI RESWKEKKDE 
                 180 
               
               
                   
               
               
                 EGKVLVEMKK WFWELNMNIV LRTVAGKQYT GTVDDADAKR ISELFREWFH YTGRFVVGDA 
                 240 
               
               
                   
               
               
                 FPFLGWLDLG GYKKTMELVA SRLDSMVSKW LDEHRKKQAN DDKKEDMDFM DIMISMTEAN 
                 300 
               
               
                   
               
               
                 SPLEGYGTDT IIKTTCMTLI VSGVDTTSIV LTWALSLLLN NRDTLKKAQE ELDMCVGKGR 
                 360 
               
               
                   
               
               
                 QVNESDLVNL IYLEAVLKEA LRLYPAAFLG GPRAFLEDCT VAGYRIPKGT CLLINMWKLH 
                 420 
               
               
                   
               
               
                 RDPNIWSDPC EFKPERFLTP NQKDVDVIGM DFELIPFGAG RRYCPGTRLA LQMLHIVLAT 
                 480 
               
               
                   
               
               
                 LLQNFEMSTP NDAPVDMTAS VGMTNAKASP LEVLLSPRVK WS 
                 522 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 107 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgatacaag ttttaactcc aattctactc ttcctcatct tcttcgtttt ctggaaagtc 
                 60 
               
               
                   
               
               
                 tacaaacatc aaaagactaa aatcaatcta ccaccaggtt ccttcggctg gccatttttg 
                 120 
               
               
                   
               
               
                 ggtgaaacct tagccttact tagagcaggc tgggattctg agccagaaag attcgtaaga 
                 180 
               
               
                   
               
               
                 gagcgtatca aaaagcatgg atctccactt gttttcaaga catcactatt tggagacaga 
                 240 
               
               
                   
               
               
                 ttcgctgttc tttgcggtcc agctggtaat aagtttttgt tctgcaacga aaacaaatta 
                 300 
               
               
                   
               
               
                 gtggcatctt ggtggccagt ccctgtaagg aagttgttcg gtaaaagttt actcacaata 
                 360 
               
               
                   
               
               
                 agaggagatg aagcaaaatg gatgagaaaa atgctattgt cttacttggg tccagatgca 
                 420 
               
               
                   
               
               
                 tttgccacac attatgccgt tactatggat gttgtaacac gtagacatat tgatgtccat 
                 480 
               
               
                   
               
               
                 tggaggggca aggaggaagt taatgtattt caaacagtta agttgtacgc attcgaatta 
                 540 
               
               
                   
               
               
                 gcttgtagat tattcatgaa cctagatgac ccaaaccaca tcgcgaaact cggtagtctt 
                 600 
               
               
                   
               
               
                 ttcaacattt tcctcaaagg gatcatcgag cttcctatag acgttcctgg aactagattt 
                 660 
               
               
                   
               
               
                 tactccagta aaaaggccgc agctgccatt agaattgaat tgaaaaagct cattaaagct 
                 720 
               
               
                   
               
               
                 agaaaactcg aattgaagga gggtaaggcg tcttcttcac aggacttgct ttctcatcta 
                 780 
               
               
                   
               
               
                 ttaacatcac ctgatgagaa tgggatgttc ttgacagaag aggaaatagt cgataacatt 
                 840 
               
               
                   
               
               
                 ctacttttgt tattcgctgg tcacgatacc tctgcactat caataacact tttgatgaaa 
                 900 
               
               
                   
               
               
                 accttaggtg aacacagtga tgtgtacgac aaggttttga aggaacaatt agaaatttcc 
                 960 
               
               
                   
               
               
                 aaaacaaagg aggcttggga atcactaaag tgggaagata tccagaagat gaagtactca 
                 1020 
               
               
                   
               
               
                 tggtcagtaa tctgtgaagt catgagattg aatcctcctg tcatagggac atacagagag 
                 1080 
               
               
                   
               
               
                 gcgttggttg atatcgacta tgctggttac actatcccaa aaggatggaa gttgcattgg 
                 1140 
               
               
                   
               
               
                 tcagctgttt ctactcaaag agacgaagcc aatttcgaag atgtaactag attcgatcca 
                 1200 
               
               
                   
               
               
                 tccagatttg aaggggcagg ccctactcca ttcacatttg tgcctttcgg tggaggtcct 
                 1260 
               
               
                   
               
               
                 agaatgtgtt taggcaaaga gtttgccagg ttagaagtgt tagcatttct ccacaacatt 
                 1320 
               
               
                   
               
               
                 gttaccaact ttaagtggga tcttctaatc cctgatgaga agatcgaata tgatccaatg 
                 1380 
               
               
                   
               
               
                 gctactccag ctaagggctt gccaattaga cttcatccac accaagtcta a 
                 1431 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 108 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MIQVLTPILL FLIFFVFWKV YKHQKTKINL PPGSFGWPFL GETLALLRAG WDSEPERFVR 
                 60 
               
               
                   
               
               
                 ERIKKHGSPL VFKTSLFGDR FAVLCGPAGN KFLFCNENKL VASWWPVPVR KLFGKSLLTI 
                 120 
               
               
                   
               
               
                 RGDEAKWMRK MLLSYLGPDA FATHYAVTMD VVTRRHIDVH WRGKEEVNVF QTVKLYAFEL 
                 180 
               
               
                   
               
               
                 ACRLFMNLDD PNHIAKLGSL FNIFLKGIIE LPIDVPGTRF YSSKKAAAAI RIELKKLIKA 
                 240 
               
               
                   
               
               
                 RKLELKEGKA SSSQDLLSHL LTSPDENGMF LTEEEIVDNI LLLLFAGHDT SALSITLLMK 
                 300 
               
               
                   
               
               
                 TLGEHSDVYD KVLKEQLEIS KTKEAWESLK WEDIQKMKYS WSVICEVMRL NPPVIGTYRE 
                 360 
               
               
                   
               
               
                 ALVDIDYAGY TIPKGWKLHW SAVSTQRDEA NFEDVTRFDP SRFEGAGPTP FTFVPFGGGP 
                 420 
               
               
                   
               
               
                 RMCLGKEFAR LEVLAFLHNI VTNFKWDLLI PDEKIEYDPM ATPAKGLPIR LHPHQV 
                 476 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 109 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggagtctt tagtggttca tacagtaaat gctatctggt gtattgtaat cgtcgggatt 
                 60 
               
               
                   
               
               
                 ttctcagttg gttatcacgt ttacggtaga gctgtggtcg aacaatggag aatgagaaga 
                 120 
               
               
                   
               
               
                 tcactgaagc tacaaggtgt taaaggccca ccaccatcca tcttcaatgg taacgtctca 
                 180 
               
               
                   
               
               
                 gaaatgcaac gtatccaatc cgaagctaaa cactgctctg gcgataacat tatctcacat 
                 240 
               
               
                   
               
               
                 gattattctt cttcattatt cccacacttc gatcactgga gaaaacagta cggcagaatc 
                 300 
               
               
                   
               
               
                 tacacatact ctactggatt aaagcaacac ttgtacatca atcatccaga aatggtgaag 
                 360 
               
               
                   
               
               
                 gagctatctc agactaacac attgaacttg ggtagaatca cccatataac caaaagattg 
                 420 
               
               
                   
               
               
                 aatcctatct taggtaacgg aatcataacc tctaatggtc ctcattgggc ccatcagcgt 
                 480 
               
               
                   
               
               
                 agaattatcg cctacgagtt tactcatgat aagatcaagg gtatggttgg tttgatggtt 
                 540 
               
               
                   
               
               
                 gagtctgcta tgcctatgtt gaataagtgg gaggagatgg taaagagagg cggagaaatg 
                 600 
               
               
                   
               
               
                 ggatgcgaca taagagttga tgaggacttg aaagatgttt cagcagatgt gattgcaaaa 
                 660 
               
               
                   
               
               
                 gcctgtttcg gatcctcatt ttctaaaggt aaggctattt tctctatgat aagagatttg 
                 720 
               
               
                   
               
               
                 cttacagcta tcacaaagag aagtgttcta ttcagattca acggattcac tgatatggtc 
                 780 
               
               
                   
               
               
                 tttgggagta aaaagcatgg tgacgttgat atagacgctt tagaaatgga attggaatca 
                 840 
               
               
                   
               
               
                 tccatttggg aaactgtcaa ggaacgtgaa atagaatgta aagatactca caaaaaggat 
                 900 
               
               
                   
               
               
                 ctgatgcaat tgattttgga aggggcaatg cgttcatgtg acggtaacct ttgggataaa 
                 960 
               
               
                   
               
               
                 tcagcatata gaagatttgt tgtagataat tgtaaatcta tctacttcgc agggcatgat 
                 1020 
               
               
                   
               
               
                 agtacagctg tctcagtgtc atggtgtttg atgttactgg ccctaaaccc atcatggcaa 
                 1080 
               
               
                   
               
               
                 gttaagatcc gtgatgaaat tctgtcttct tgcaaaaatg gtattccaga tgccgaaagt 
                 1140 
               
               
                   
               
               
                 atcccaaacc ttaaaacagt gactatggtt attcaagaga caatgagatt ataccctcca 
                 1200 
               
               
                   
               
               
                 gcaccaatcg tcgggagaga agcctctaaa gatatcagat tgggcgatct agttgttcct 
                 1260 
               
               
                   
               
               
                 aaaggcgtct gtatatggac actaatacca gctttacaca gagatcctga gatttgggga 
                 1320 
               
               
                   
               
               
                 ccagatgcaa acgatttcaa accagaaaga ttttctgaag gaatttcaaa ggcttgtaag 
                 1380 
               
               
                   
               
               
                 tatcctcaaa gttacattcc atttggtctg ggtcctagaa catgcgttgg taaaaacttt 
                 1440 
               
               
                   
               
               
                 ggcatgatgg aagtaaaggt tcttgtttcc ctgattgtct ccaagttctc tttcactcta 
                 1500 
               
               
                   
               
               
                 tctcctacct accaacatag tcctagtcac aaacttttag tagaaccaca acatggggtg 
                 1560 
               
               
                   
               
               
                 gtaattagag tggtttaa 
                 1578 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 110 
               
               
                 
                   A. thaliana 
                 
               
            
           
           
               
               
            
               
                 MESLVVHTVN AIWCIVIVGI FSVGYHVYGR AVVEQWRMRR SLKLQGVKGP PPSIFNGNVS 
                 60 
               
               
                   
               
               
                 EMQRIQSEAK HCSGDNIISH DYSSSLFPHF DHWRKQYGRI YTYSTGLKQH LYINHPEMVK 
                 120 
               
               
                   
               
               
                 ELSQTNTLNL GRITHITKRL NPILGNGIIT SNGPHWAHQR RIIAYEFTHD KIKGMVGLMV 
                 180 
               
               
                   
               
               
                 ESAMPMLNKW EEMVKRGGEM GCDIRVDEDL KDVSADVIAK ACFGSSFSKG KAIFSMIRDL 
                 240 
               
               
                   
               
               
                 LTAITKRSVL FRFNGFTDMV FGSKKHGDVD IDALEMELES SIWETVKERE IECKDTHKKD 
                 300 
               
               
                   
               
               
                 LMQLILEGAM RSCDGNLWDK SAYRRFVVDN CKSIYFAGHD STAVSVSWCL MLLALNPSWQ 
                 360 
               
               
                   
               
               
                 VKIRDEILSS CKNGIPDAES IPNLKTVTMV IQETMRLYPP APIVGREASK DIRLGDLVVP 
                 420 
               
               
                   
               
               
                 KGVCIWTLIP ALHRDPEIWG PDANDFKPER FSEGISKACK YPQSYIPFGL GPRTCVGKNF 
                 480 
               
               
                   
               
               
                 GMMEVKVLVS LIVSKFSFTL SPTYQHSPSH KLLVEPQHGV VIRVV 
                 525 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 111 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atgtacttcc tactacaata cctcaacatc acaaccgttg gtgtctttgc cacattgttt 
                 60 
               
               
                   
               
               
                 ctctcttatt gtttacttct ctggagaagt agagcgggta acaaaaagat tgccccagaa 
                 120 
               
               
                   
               
               
                 gctgccgctg catggcctat tatcggccac ctccacttac ttgcaggtgg atcccatcaa 
                 180 
               
               
                   
               
               
                 ctaccacata ttacattggg taacatggca gataagtacg gtcctgtatt cacaatcaga 
                 240 
               
               
                   
               
               
                 ataggcttgc atagagctgt agttgtctca tcttgggaaa tggcaaagga atgttcaaca 
                 300 
               
               
                   
               
               
                 gctaatgatc aagtgtcttc ttcaagacct gaactattag cttctaagtt gttgggttat 
                 360 
               
               
                   
               
               
                 aactacgcca tgtttggttt ttcaccatac ggttcatact ggagagaaat gagaaagatc 
                 420 
               
               
                   
               
               
                 atctctctcg aattactatc taattccaga ttggaactat tgaaagatgt tagagcctca 
                 480 
               
               
                   
               
               
                 gaagttgtca catctattaa ggaactatac aaattgtggg cggaaaagaa gaatgagtca 
                 540 
               
               
                   
               
               
                 ggattggttt ctgtcgagat gaaacaatgg ttcggagatt tgactttaaa cgtgatcttg 
                 600 
               
               
                   
               
               
                 agaatggtgg ctggtaaaag atacttctcc gcgagtgacg cttcagaaaa caaacaggcc 
                 660 
               
               
                   
               
               
                 cagcgttgta gaagagtctt cagagaattc ttccatctct ccggcttgtt tgtggttgct 
                 720 
               
               
                   
               
               
                 gatgctatac cttttcttgg atggctcgat tggggaagac acgagaagac cttgaaaaag 
                 780 
               
               
                   
               
               
                 accgccatag aaatggattc catcgcccag gagtggcttg aggaacatag acgtagaaaa 
                 840 
               
               
                   
               
               
                 gattctggag atgataattc tacccaagat ttcatggacg ttatgcaatc tgtgctagat 
                 900 
               
               
                   
               
               
                 ggcaaaaatc taggcggata cgatgctgat acgattaaca aggctacatg cttaactctt 
                 960 
               
               
                   
               
               
                 atatcaggtg gcagtgatac tactgtagtt tctttgacat gggctcttag tcttgtgtta 
                 1020 
               
               
                   
               
               
                 aacaatagag atactttgaa aaaggcacag gaagagttag acatccaagt cggtaaggaa 
                 1080 
               
               
                   
               
               
                 agattggtta acgagcaaga catcagtaag ttagtttact tgcaagcaat agtaaaagag 
                 1140 
               
               
                   
               
               
                 acactcagac tttatccacc aggtcctttg ggtggtttga gacaattcac tgaagattgt 
                 1200 
               
               
                   
               
               
                 acactaggtg gctatcacgt ttcaaaagga actagattaa tcatgaactt atccaagatt 
                 1260 
               
               
                   
               
               
                 caaaaagatc cacgtatttg gtctgatcct actgaattcc aaccagagag attccttacg 
                 1320 
               
               
                   
               
               
                 actcataaag atgtcgatcc acgtggtaaa cactttgaat tcattccatt cggtgcagga 
                 1380 
               
               
                   
               
               
                 agacgtgcat gtcctggtat cacattcgga ttacaagtac tacatctaac attggcatct 
                 1440 
               
               
                   
               
               
                 ttcttgcatg cgtttgaatt ttcaacacca tcaaatgagc aggttaacat gagagaatca 
                 1500 
               
               
                   
               
               
                 ttaggtctta cgaatatgaa atctacccca ttagaagttt tgatttctcc aagactatcc 
                 1560 
               
               
                   
               
               
                 cttaattgct tcaaccttat gaaaatttga 
                 1590 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 112 
               
               
                 
                   V. vinifera 
                 
               
            
           
           
               
               
            
               
                 MYFLLQYLNI TTVGVFATLF LSYCLLLWRS RAGNKKIAPE AAAAWPIIGH LHLLAGGSHQ 
                 60 
               
               
                   
               
               
                 LPHITLGNMA DKYGPVFTIR IGLHRAVVVS SWEMAKECST ANDQVSSSRP ELLASKLLGY 
                 120 
               
               
                   
               
               
                 NYAMFGFSPY GSYWREMRKI ISLELLSNSR LELLKDVRAS EVVTSIKELY KLWAEKKNES 
                 180 
               
               
                   
               
               
                 GLVSVEMKQW FGDLTLNVIL RMVAGKRYFS ASDASENKQA QRCRRVFREF FHLSGLFVVA 
                 240 
               
               
                   
               
               
                 DAIPFLGWLD WGRHEKTLKK TAIEMDSIAQ EWLEEHRRRK DSGDDNSTQD FMDVMQSVLD 
                 300 
               
               
                   
               
               
                 GKNLGGYDAD TINKATCLTL ISGGSDTTVV SLTWALSLVL NNRDTLKKAQ EELDIQVGKE 
                 360 
               
               
                   
               
               
                 RLVNEQDISK LVYLQAIVKE TLRLYPPGPL GGLRQFTEDC TLGGYHVSKG TRLIMNLSKI 
                 420 
               
               
                   
               
               
                 QKDPRIWSDP TEFQPERFLT THKDVDPRGK HFEFIPFGAG RRACPGITFG LQVLHLTLAS 
                 480 
               
               
                   
               
               
                 FLHAFEFSTP SNEQVNMRES LGLTNMKSTP LEVLISPRLS SCSLYN 
                 526 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 113 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggaaccta acttttactt gtcattacta ttgttgttcg tgaccttcat ttctttaagt 
                 60 
               
               
                   
               
               
                 ctgtttttca tcttttacaa acaaaagtcc ccattgaatt tgccaccagg gaaaatgggt 
                 120 
               
               
                   
               
               
                 taccctatca taggtgaaag tttagaattc ctatccacag gctggaaggg acatcctgaa 
                 180 
               
               
                   
               
               
                 aagttcatat ttgatagaat gcgtaagtac agtagtgagt tattcaagac ttctattgta 
                 240 
               
               
                   
               
               
                 ggcgaatcca cagttgtttg ctgtggggca gctagtaaca aattcctatt ctctaacgaa 
                 300 
               
               
                   
               
               
                 aacaaactgg taactgcctg gtggccagat tctgttaaca aaatcttccc aacaacttca 
                 360 
               
               
                   
               
               
                 ctggattcta atttgaagga ggaatctata aagatgagaa agttgctgcc acagttcttc 
                 420 
               
               
                   
               
               
                 aaaccagaag cacttcaaag atacgtcggc gttatggatg taatcgcaca aagacatttt 
                 480 
               
               
                   
               
               
                 gtcactcact gggacaacaa aaatgagatc acagtttatc cacttgctaa aagatacact 
                 540 
               
               
                   
               
               
                 ttcttgcttg cgtgtagact gttcatgtct gttgaggatg aaaatcatgt ggcgaaattc 
                 600 
               
               
                   
               
               
                 tcagacccat tccaactaat cgctgcaggc atcatttcac ttcctatcga tcttcctggt 
                 660 
               
               
                   
               
               
                 actccattca acaaggccat aaaggcttca aatttcatta gaaaagagct gataaagatt 
                 720 
               
               
                   
               
               
                 atcaaacaaa gacgtgttga tctggcagag ggtacagcat ctccaaccca ggatatcttg 
                 780 
               
               
                   
               
               
                 tcacatatgc tattaacatc tgatgaaaac ggtaaatcta tgaacgagtt gaacattgcc 
                 840 
               
               
                   
               
               
                 gacaagattc ttggactatt gataggaggc cacgatacag cttcagtagc ttgcacattt 
                 900 
               
               
                   
               
               
                 ctagtgaagt acttaggaga attaccacat atctacgata aagtctacca agagcaaatg 
                 960 
               
               
                   
               
               
                 gaaattgcca agtccaaacc tgctggggaa ttgttgaatt gggatgactt gaaaaagatg 
                 1020 
               
               
                   
               
               
                 aagtattcat ggaatgtggc atgtgaggta atgagattgt caccaccttt acaaggtggt 
                 1080 
               
               
                   
               
               
                 tttagagagg ctataactga ctttatgttt aacggtttct ctattccaaa agggtggaag 
                 1140 
               
               
                   
               
               
                 ttatactggt ccgccaactc tacacacaaa aatgcagaat gtttcccaat gcctgagaaa 
                 1200 
               
               
                   
               
               
                 ttcgatccta ccagatttga aggtaatggt ccagcgcctt atacatttgt accattcggt 
                 1260 
               
               
                   
               
               
                 ggaggcccta gaatgtgtcc tggaaaggaa tacgctagat tagaaatctt ggttttcatg 
                 1320 
               
               
                   
               
               
                 cataatctgg tcaaacgttt taagtgggaa aaggttattc cagacgaaaa gattattgtc 
                 1380 
               
               
                   
               
               
                 gatccattcc caatcccagc taaagatctt ccaatccgtt tgtatcctca caaagcttaa 
                 1440 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 114 
               
               
                 
                   M. truncatula 
                 
               
            
           
           
               
               
            
               
                 MEPNFYLSLL LLFVTFISLS LFFIFYKQKS PLNLPPGKMG YPIIGESLEF LSTGWKGHPE 
                 60 
               
               
                   
               
               
                 KFIFDRMRKY SSELFKTSIV GESTVVCCGA ASNKFLFSNE NKLVTAWWPD SVNKIFPTTS 
                 120 
               
               
                   
               
               
                 LDSNLKEESI KMRKLLPQFF KPEALQRYVG VMDVIAQRHF VTHWDNKNEI TVYPLAKRYT 
                 180 
               
               
                   
               
               
                 FLLACRLFMS VEDENHVAKF SDPFQLIAAG IISLPIDLPG TPFNKAIKAS NFIRKELIKI 
                 240 
               
               
                   
               
               
                 IKQRRVDLAE GTASPTQDIL SHMLLTSDEN GKSMNELNIA DKILGLLIGG HDTASVACTF 
                 300 
               
               
                   
               
               
                 LVKYLGELPH IYDKVYQEQM EIAKSKPAGE LLNWDDLKKM KYSWNVACEV MRLSPPLQGG 
                 360 
               
               
                   
               
               
                 FREAITDFMF NGFSIPKGWK LYWSANSTHK NAECFPMPEK FDPTRFEGNG PAPYTFVPFG 
                 420 
               
               
                   
               
               
                 GGPRMCPGKE YARLEILVFM HNLVKRFKWE KVIPDEKIIV DPFPIPAKDL PIRLYPHKA 
                 479 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 115 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atggcctctg ttactttggg ttcctggatc gtcgtccacc accataacca tcaccatcca 
                 60 
               
               
                   
               
               
                 tcatctatcc taactaaatc tcgttcaaga tcctgtccta ttacactaac caaaccaatc 
                 120 
               
               
                   
               
               
                 tcttttcgtt caaagagaac agtttcctct agtagttcta tcgtgtcctc tagtgtcgtc 
                 180 
               
               
                   
               
               
                 actaaggaag acaatctgag acagtctgaa ccttcttcct ttgatttcat gtcatatatc 
                 240 
               
               
                   
               
               
                 attactaagg cagaactagt gaataaggct cttgattcag cagttccatt aagagagcca 
                 300 
               
               
                   
               
               
                 ttgaaaatcc atgaagcaat gagatactct cttctagctg gcgggaagag agtcagacct 
                 360 
               
               
                   
               
               
                 gtactctgca tagcagcgtg cgaattagtt ggtggcgagg aatcaaccgc tatgcctgcc 
                 420 
               
               
                   
               
               
                 gcttgtgctg tagaaatgat tcatacaatg tcactgatac acgatgattt gccatgtatg 
                 480 
               
               
                   
               
               
                 gataacgatg atctgagaag gggtaagcca actaaccata aggttttcgg cgaagatgtt 
                 540 
               
               
                   
               
               
                 gccgtcttag ctggtgatgc tttgttatct ttcgcgttcg aacatttggc atccgcaaca 
                 600 
               
               
                   
               
               
                 tcaagtgatg ttgtgtcacc agtaagagta gttagagcag ttggagaact ggctaaagct 
                 660 
               
               
                   
               
               
                 attggaactg agggtttagt tgcaggtcaa gtcgtcgata tctcttccga aggtcttgat 
                 720 
               
               
                   
               
               
                 ttgaatgatg taggtcttga acatctcgaa ttcatccatc ttcacaagac agctgcactt 
                 780 
               
               
                   
               
               
                 ttagaagcca gtgcggttct cggcgcaatt gttggcggag ggagtgatga cgaaattgag 
                 840 
               
               
                   
               
               
                 agattgagga agtttgctag atgtatagga ttactgttcc aagtagtaga cgatatacta 
                 900 
               
               
                   
               
               
                 gatgtgacaa agtcttccaa agagttggga aaaacagctg gtaaagattt gattgccgac 
                 960 
               
               
                   
               
               
                 aaattgacct accctaagat tatggggcta gaaaaatcaa gagaatttgc cgagaaactc 
                 1020 
               
               
                   
               
               
                 aatagagagg cgcgtgatca actgttgggt ttcgattctg ataaagttgc accactctta 
                 1080 
               
               
                   
               
               
                 gccttagcca actacatcgc ttacagacaa aactaa 
                 1116 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 116 
               
               
                 
                   A. thaliana 
                 
               
            
           
           
               
               
            
               
                 MASVTLGSWI VVHHHNHHHP SSILTKSRSR SCPITLTKPI SFRSKRTVSS SSSIVSSSVV 
                 60 
               
               
                   
               
               
                 TKEDNLRQSE PSSFDFMSYI ITKAELVNKA LDSAVPLREP LKIHEAMRYS LLAGGKRVRP 
                 120 
               
               
                   
               
               
                 VLCIAACELV GGEESTAMPA ACAVEMIHTM SLIHDDLPCM DNDDLRRGKP TNHKVFGEDV 
                 180 
               
               
                   
               
               
                 AVLAGDALLS FAFEHLASAT SSDVVSPVRV VRAVGELAKA IGTEGLVAGQ VVDISSEGLD 
                 240 
               
               
                   
               
               
                 LNDVGLEHLE FIHLHKTAAL LEASAVLGAI VGGGSDDEIE RLRKFARCIG LLFQVVDDIL 
                 300 
               
               
                   
               
               
                 DVTKSSKELG KTAGKDLIAD KLTYPKIMGL EKSREFAEKL NREARDQLLG FDSDKVAPLL 
                 360 
               
               
                   
               
               
                 ALANYIAYRQ N 
                 371 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 117 
               
               
                 
                   R. suavissimus 
                 
               
            
           
           
               
               
            
               
                 MATLLEHFQA MPFAIPIALA ALSWLFLFYI KVSFFSNKSA QAKLPPVPVV PGLPVIGNLL 
                 60 
               
               
                   
               
               
                 QLKEKKPYQT FTRWAEEYGP IYSIRTGAST MVVLNTTQVA KEAMVTRYLS ISTRKLSNAL 
                 120 
               
               
                   
               
               
                 KILTADKCMV AISDYNDFHK MIKRYILSNV LGPSAQKRHR SNRDTLRANV CSRLHSQVKN 
                 180 
               
               
                   
               
               
                 SPREAVNFRR VFEWELFGIA LKQAFGKDIE KPIYVEELGT TLSRDEIFKV LVLDIMEGAI 
                 240 
               
               
                   
               
               
                 EVDWRDFFPY LRWIPNTRME TKIQRLYFRR KAVMTALINE QKKRIASGEE INCYIDFLLK 
                 300 
               
               
                   
               
               
                 EGKTLTMDQI SMLLWETVIE TADTTMVTTE WAMYEVAKDS KRQDRLYQEI QKVCGSEMVT 
                 360 
               
               
                   
               
               
                 EEYLSQLPYL NAVFHETLRK HSPAALVPLR YAHEDTQLGG YYIPAGTEIA INIYGCNMDK 
                 420 
               
               
                   
               
               
                 HQWESPEEWK PERFLDPKFD PMDLYKTMAF GAGKRVCAGS LQAMLIACPT IGRLVQEFEW 
                 480 
               
               
                   
               
               
                 KLRDGEEENV DTVGLTTHKR YPMHAILKPR S 
                 511 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 118 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 atgtcatttc aaattgaaac ggttcccacc aaaccatatg aagaccaaaa gcctggtacc 
                 60 
               
               
                   
               
               
                 tctggtttgc gtaagaagac aaaggtgttt aaagacgaac ctaactacac agaaaatttc 
                 120 
               
               
                   
               
               
                 attcaatcga tcatggaagc tattccagag ggttctaaag gtgccactct tgttgtcggt 
                 180 
               
               
                   
               
               
                 ggtgatgggc gttactacaa tgatgtcatt cttcataaga ttgccgctat cggtgctgcc 
                 240 
               
               
                   
               
               
                 aacggtatta aaaagttagt tattggccag catggtcttc tgtctacgcc agccgcttct 
                 300 
               
               
                   
               
               
                 cacatcatga gaacctacga ggaaaaatgt actggtggta ttatcttaac cgcctcacat 
                 360 
               
               
                   
               
               
                 aatccaggtg gtccagaaaa tgacatgggt attaagtata acttatccaa tgggggtcct 
                 420 
               
               
                   
               
               
                 gctcctgaat ccgtcacaaa tgctatttgg gagatttcca aaaagcttac cagctataag 
                 480 
               
               
                   
               
               
                 attatcaaag acttcccaga actagacttg ggtacgatag gcaagaacaa gaaatacggt 
                 540 
               
               
                   
               
               
                 ccattactcg ttgacattat cgatattaca aaagattatg tcaacttctt gaaggaaatc 
                 600 
               
               
                   
               
               
                 ttcgatttcg acttaatcaa gaaattcatc gataatcaac gttctactaa gaattggaag 
                 660 
               
               
                   
               
               
                 ttactgtttg acagtatgaa cggtgtaact ggaccatacg gtaaggctat tttcgttgat 
                 720 
               
               
                   
               
               
                 gaatttggtt taccggcgga tgaggtttta caaaactggc atccttctcc ggattttggt 
                 780 
               
               
                   
               
               
                 ggtatgcatc cagatccaaa cttaacttat gccagttcgt tagtgaaaag agtagatcgt 
                 840 
               
               
                   
               
               
                 gaaaagattg agtttggtgc tgcatccgat ggtgatggtg atagaaatat gatttacggt 
                 900 
               
               
                   
               
               
                 tacggcccat ctttcgtttc tccaggtgac tccgtcgcaa ttattgccga atatgcagct 
                 960 
               
               
                   
               
               
                 gaaatcccat atttcgccaa gcaaggtata tatggtctgg cccgttcatt ccctacctca 
                 1020 
               
               
                   
               
               
                 ggagccatag accgtgttgc caaggcccat ggtctaaact gttatgaggt cccaactggc 
                 1080 
               
               
                   
               
               
                 tggaaatttt tctgtgcttt gttcgacgct aaaaaattat ctatttgtgg tgaagaatcg 
                 1140 
               
               
                   
               
               
                 tttggtactg gttccaacca cgtaagggaa aaggacggtg tttgggccat tatggcgtgg 
                 1200 
               
               
                   
               
               
                 ttgaacatct tggccattta caacaagcat catccggaga acgaagcttc tattaagacg 
                 1260 
               
               
                   
               
               
                 atacagaatg aattctgggc aaagtacggc cgtactttct tcactcgtta tgattttgaa 
                 1320 
               
               
                   
               
               
                 aaagttgaaa cagaaaaagc taacaagatt gtcgatcaat tgagagcata tgttaccaaa 
                 1380 
               
               
                   
               
               
                 tcgggtgttg ttaattccgc cttcccagcc gatgagtctc ttaaggtcac cgattgtggt 
                 1440 
               
               
                   
               
               
                 gatttttcat acacagattt ggacggttct gtttctgacc atcaaggttt atatgtcaag 
                 1500 
               
               
                   
               
               
                 ctttccaatg gtgcaagatt cgttctaaga ttgtcaggta caggttcttc aggtgctacc 
                 1560 
               
               
                   
               
               
                 attagattgt acattgaaaa atactgcgat gataaatcac aataccaaaa gacagctgaa 
                 1620 
               
               
                   
               
               
                 gaatacttga agccaattat taactcggtc atcaagttct tgaactttaa acaagtttta 
                 1680 
               
               
                   
               
               
                 ggaactgaag aaccaacggt tcgtacttaa 
                 1710 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 119 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 MSFQIETVPT KPYEDQKPGT SGLRKKTKVF KDEPNYTENF IQSIMEAIPE GSKGATLVVG 
                 60 
               
               
                   
               
               
                 GDGRYYNDVI LHKIAAIGAA NGIKKLVIGQ HGLLSTPAAS HIMRTYEEKC TGGIILTASH 
                 120 
               
               
                   
               
               
                 NPGGPENDMG IKYNLSNGGP APESVTNAIW EISKKLTSYK IIKDFPELDL GTIGKNKKYG 
                 180 
               
               
                   
               
               
                 PLLVDIIDIT KDYVNFLKEI FDFDLIKKFI DNQRSTKNWK LLFDSMNGVT GPYGKAIFVD 
                 240 
               
               
                   
               
               
                 EFGLPADEVL QNWHPSPDFG GMHPDPNLTY ASSLVKRVDR EKIEFGAASD GDGDRNMIYG 
                 300 
               
               
                   
               
               
                 YGPSFVSPGD SVAIIAEYAA EIPYFAKQGI YGLARSFPTS GAIDRVAKAH GLNCYEVPTG 
                 360 
               
               
                   
               
               
                 WKFFCALFDA KKLSICGEES FGTGSNHVRE KDGVWAIMAW LNILAIYNKH HPENEASIKT 
                 420 
               
               
                   
               
               
                 IQNEFWAKYG RTFFTRYDFE KVETEKANKI VDQLRAYVTK SGVVNSAFPA DESLKVTDCG 
                 480 
               
               
                   
               
               
                 DFSYTDLDGS VSDHQGLYVK LSNGARFVLR LSGTGSSGAT IRLYIEKYCD DKSQYQKTAE 
                 540 
               
               
                   
               
               
                 EYLKPIINSV IKFLNFKQVL GTEEPTVRT 
                 569 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 120 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 atgtccacta agaagcacac caaaacacat tccacttatg cattcgagag caacacaaac 
                 60 
               
               
                   
               
               
                 agcgttgctg cctcacaaat gagaaacgcc ttaaacaagt tggcggactc tagtaaactt 
                 120 
               
               
                   
               
               
                 gacgatgctg ctcgcgctaa gtttgagaac gaactggatt cgtttttcac gcttttcagg 
                 180 
               
               
                   
               
               
                 agatatttgg tagagaagtc ttctagaacc accttggaat gggacaagat caagtctccc 
                 240 
               
               
                   
               
               
                 aacccggatg aagtggttaa gtatgaaatt atttctcagc agcccgagaa tgtctcaaac 
                 300 
               
               
                   
               
               
                 ctttccaaat tggctgtttt gaagttgaac ggtgggctgg gtacctccat gggctgcgtt 
                 360 
               
               
                   
               
               
                 ggccctaaat ctgttattga agtgagagag ggaaacacct ttttggattt gtctgttcgt 
                 420 
               
               
                   
               
               
                 caaattgaat acttgaacag acagtacgat agcgacgtgc cattgttatt gatgaattct 
                 480 
               
               
                   
               
               
                 ttcaacactg acaaggatac ggaacacttg attaagaagt attccgctaa cagaatcaga 
                 540 
               
               
                   
               
               
                 atcagatctt tcaatcaatc caggttccca agagtctaca aggattcttt attgcctgtc 
                 600 
               
               
                   
               
               
                 cccaccgaat acgattctcc actggatgct tggtatccac caggtcacgg tgatttgttt 
                 660 
               
               
                   
               
               
                 gaatctttac acgtatctgg tgaactggat gccttaattg cccaaggaag agaaatatta 
                 720 
               
               
                   
               
               
                 tttgtttcta acggtgacaa cttgggtgct accgtcgact taaaaatttt aaaccacatg 
                 780 
               
               
                   
               
               
                 atcgagactg gtgccgaata tataatggaa ttgactgata agaccagagc cgatgttaaa 
                 840 
               
               
                   
               
               
                 ggtggtactt tgatttctta cgatggtcaa gtccgtttat tggaagtcgc ccaagttcca 
                 900 
               
               
                   
               
               
                 aaagaacaca ttgacgaatt caaaaatatc agaaagttta ccaacttcaa cacgaataac 
                 960 
               
               
                   
               
               
                 ttatggatca atctgaaagc agtaaagagg ttgatcgaat cgagcaattt ggagatggaa 
                 1020 
               
               
                   
               
               
                 atcattccaa accaaaaaac tataacaaga gacggtcatg aaattaatgt cttacaatta 
                 1080 
               
               
                   
               
               
                 gaaaccgctt gtggtgctgc tatcaggcat tttgatggtg ctcacggtgt tgtcgttcca 
                 1140 
               
               
                   
               
               
                 agatcaagat tcttgcctgt caagacctgt tccgatttgt tgctggttaa atcagatcta 
                 1200 
               
               
                   
               
               
                 ttccgtctgg aacacggttc tttgaagtta gacccatccc gttttggtcc aaacccatta 
                 1260 
               
               
                   
               
               
                 atcaagttgg gctcgcattt caaaaaggtt tctggtttta acgcaagaat ccctcacatc 
                 1320 
               
               
                   
               
               
                 ccaaaaatcg tcgagctaga tcatttgacc atcactggta acgtcttttt aggtaaagat 
                 1380 
               
               
                   
               
               
                 gtcactttga ggggtactgt catcatcgtt tgctccgacg gtcataaaat cgatattcca 
                 1440 
               
               
                   
               
               
                 aacggctcca tattggaaaa tgttgtcgtt actggtaatt tgcaaatctt ggaacattga 
                 1500 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 121 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 MSTKKHTKTH STYAFESNTN SVAASQMRNA LNKLADSSKL DDAARAKFEN ELDSFFTLFR 
                 60 
               
               
                   
               
               
                 RYLVEKSSRT TLEWDKIKSP NPDEVVKYEI ISQQPENVSN LSKLAVLKLN GGLGTSMGCV 
                 120 
               
               
                   
               
               
                 GPKSVIEVRE GNTFLDLSVR QIEYLNRQYD SDVPLLLMNS FNTDKDTEHL IKKYSANRIR 
                 180 
               
               
                   
               
               
                 IRSFNQSRFP RVYKDSLLPV PTEYDSPLDA WYPPGHGDLF ESLHVSGELD ALIAQGREIL 
                 240 
               
               
                   
               
               
                 FVSNGDNLGA TVDLKILNHM IETGAEYIME LTDKTRADVK GGTLISYDGQ VRLLEVAQVP 
                 300 
               
               
                   
               
               
                 KEHIDEFKNI RKFTNFNTNN LWINLKAVKR LIESSNLEME IIPNQKTITR DGHEINVLQL 
                 360 
               
               
                   
               
               
                 ETACGAAIRH FDGAHGVVVP RSRFLPVKTC SDLLLVKSDL FRLEHGSLKL DPSRFGPNPL 
                 420 
               
               
                   
               
               
                 IKLGSHFKKV SGFNARIPHI PKIVELDHLT ITGNVFLGKD VTLRGTVIIV CSDGHKIDIP 
                 480 
               
               
                   
               
               
                 NGSILENVVV TGNLQILEH 
                 499 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 122 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 atgtctagtc aaacagaaag aacttttatt gcggtaaaac cagatggtgt ccagaggggc 
                 60 
               
               
                   
               
               
                 ttagtatctc aaattctatc tcgttttgaa aaaaaaggtt acaaactagt tgctattaaa 
                 120 
               
               
                   
               
               
                 ttagttaaag cggatgataa attactagag caacattacg cagagcatgt tggtaaacca 
                 180 
               
               
                   
               
               
                 tttttcccaa agatggtatc ctttatgaag tctggtccca ttttggccac ggtctgggag 
                 240 
               
               
                   
               
               
                 ggaaaagatg tggttagaca aggaagaact attcttggtg ctactaatcc tttgggcagt 
                 300 
               
               
                   
               
               
                 gcaccaggta ccattagagg tgatttcggt attgacctag gcagaaacgt ctgtcacggc 
                 360 
               
               
                   
               
               
                 agtgattctg ttgatagcgc tgaacgtgaa atcaatttgt ggtttaagaa ggaagagtta 
                 420 
               
               
                   
               
               
                 gttgattggg aatctaatca agctaagtgg atttatgaat ga 
                 462 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 123 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 MSSQTERTFI AVKPDGVQRG LVSQILSRFE KKGYKLVAIK LVKADDKLLE QHYAEHVGKP 
                 60 
               
               
                   
               
               
                 FFPKMVSFMK SGPILATVWE GKDVVRQGRT ILGATNPLGS APGTIRGDFG IDLGRNVCHG 
                 120 
               
               
                   
               
               
                 SDSVDSAERE INLWFKKEEL VDWESNQAKW IYE 
                 153 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 124 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 atggctgctg ctgatactga aaagttgaac aatttgagat ccgccgtttc tggtttgacc 
                 60 
               
               
                   
               
               
                 caaatttctg ataacgaaaa gtccggtttc atcaacttgg tcagtagata tttgtctggt 
                 120 
               
               
                   
               
               
                 gaagctcaac acgttgaatg gtctaaaatt caaactccaa ccgataagat cgttgttcca 
                 180 
               
               
                   
               
               
                 tacgatactt tgtctgctgt tccagaagat gctgctcaaa caaaatcttt gttggataag 
                 240 
               
               
                   
               
               
                 ttggtcgtct tgaagttgaa cggtggtttg ggtactacta tgggttgtac tggtccaaag 
                 300 
               
               
                   
               
               
                 tctgttatcg aagttagaaa cggtttgacc ttcttggatt tgatcgtcat ccaaatcgaa 
                 360 
               
               
                   
               
               
                 tccttgaaca agaagtacgg ttgttctgtt cctttgttgt tgatgaactc tttcaacacc 
                 420 
               
               
                   
               
               
                 catgaagata cccaaaagat cgtcgaaaag tactccggtt ctaacattga agttcacacc 
                 480 
               
               
                   
               
               
                 ttcaatcaat cccaataccc aagattggtt gtcgatgaat ttttgccatt gccatctaaa 
                 540 
               
               
                   
               
               
                 ggtgaaactg gtaaagatgg ttggtatcca ccaggtcatg gtgatgtttt tccatccttg 
                 600 
               
               
                   
               
               
                 atgaattccg gtaagttgga tgctttgttg tcccaaggta aagaatacgt tttcgttgcc 
                 660 
               
               
                   
               
               
                 aactctgata acttgggtgc agttgttgat ttgaagatct tgaaccactt gatccaaaac 
                 720 
               
               
                   
               
               
                 aagaacgaat actgcatgga agttactcca aagactttgg ctgatgttaa gggtggtact 
                 780 
               
               
                   
               
               
                 ttgatttctt acgatggtaa ggttcaatta ttggaaatcg cccaagttcc agatgaacac 
                 840 
               
               
                   
               
               
                 gttaatgaat tcaagtccat cgaaaagttt aagatcttta acactaacaa cttgtgggtc 
                 900 
               
               
                   
               
               
                 aacttgaacg ccattaagag attggttcaa gctgatgctt tgaagatgga aattattcca 
                 960 
               
               
                   
               
               
                 aatccaaaag aagtcaacgg tgtcaaggta ttgcaattgg aaactgctgc tggtgctgct 
                 1020 
               
               
                   
               
               
                 attaagtttt tcgataatgc catcggtatc aacgtcccaa gatctagatt tttgcctgtt 
                 1080 
               
               
                   
               
               
                 aaggcttcct ctgacttgtt gttagttcaa tcagacttgt acaccgaaaa ggatggttac 
                 1140 
               
               
                   
               
               
                 gttattagaa acccagctag aaaggatcca gctaacccat ctattgaatt gggtccagaa 
                 1200 
               
               
                   
               
               
                 ttcaaaaagg tcggtgattt cttgaagaga ttcaagtcta tcccatccat catcgaattg 
                 1260 
               
               
                   
               
               
                 gactcattga aagtttctgg tgatgtctgg tttggttcca acgttgtttt gaaaggtaag 
                 1320 
               
               
                   
               
               
                 gttgttgttg ctgccaaatc cggtgaaaaa ttggaaattc cagatggtgc cttgattgaa 
                 1380 
               
               
                   
               
               
                 aacaaagaag ttcatggtgc ctccgacatt tga 
                 1413 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 125 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 MAAADTEKLN NLRSAVSGLT QISDNEKSGF INLVSRYLSG EAQHVEWSKI QTPTDKIVVP 
                 60 
               
               
                   
               
               
                 YDTLSAVPED AAQTKSLLDK LVVLKLNGGL GTTMGCTGPK SVIEVRNGLT FLDLIVIQIE 
                 120 
               
               
                   
               
               
                 SLNKKYGCSV PLLLMNSFNT HEDTQKIVEK YSGSNIEVHT FNQSQYPRLV VDEFLPLPSK 
                 180 
               
               
                   
               
               
                 GETGKDGWYP PGHGDVFPSL MNSGKLDALL SQGKEYVFVA NSDNLGAVVD LKILNHLIQN 
                 240 
               
               
                   
               
               
                 KNEYCMEVTP KTLADVKGGT LISYDGKVQL LEIAQVPDEH VNEFKSIEKF KIFNTNNLWV 
                 300 
               
               
                   
               
               
                 NLNAIKRLVQ ADALKMEIIP NPKEVNGVKV LQLETAAGAA IKFFDNAIGI NVPRSRFLPV 
                 360 
               
               
                   
               
               
                 KASSDLLLVQ SDLYTEKDGY VIRNPARKDP ANPSIELGPE FKKVGDFLKR FKSIPSIIEL 
                 420 
               
               
                   
               
               
                 DSLKVSGDVW FGSNVVLKGK VVVAAKSGEK LEIPDGALIE NKEVHGASDI 
                 470 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 126 
               
               
                 
                   A. pullulans 
                 
               
            
           
           
               
               
            
               
                 atgtcctctg aaatggctac tcatttgaaa cctaatggtg gtgccgaatt cgaaaaaaga 
                 60 
               
               
                   
               
               
                 catcatggta agacccaatc ccatgttgct tttgaaaaca cttctacatc tgttgctgcc 
                 120 
               
               
                   
               
               
                 tcccaaatga gaaatgcttt gaatactttg tgcgattccg ttactgatcc agctgaaaag 
                 180 
               
               
                   
               
               
                 caaagattcg aaaccgaaat ggataacttc ttcgccttgt ttagaagata cttgaacgat 
                 240 
               
               
                   
               
               
                 aaggctaagg gtaacgaaat cgaatggtct agaattgctc caccaaaacc agaacaagtt 
                 300 
               
               
                   
               
               
                 gttgcttatc aagacttgcc tgaacaagaa tccgttgaat tcttgaacaa attggccgtc 
                 360 
               
               
                   
               
               
                 ttgaagttga atggtggttt gggtacttct atgggttgtg ttggtccaaa gtctgttatc 
                 420 
               
               
                   
               
               
                 gaagttagag atggtatgtc cttcttggat ttgtccgtta gacaaatcga atacttgaat 
                 480 
               
               
                   
               
               
                 agaacctacg gtgttaacgt tccattcgtc ttgatgaatt ctttcaacac tgatgctgat 
                 540 
               
               
                   
               
               
                 accgccaaca ttatcaaaaa gtacgaaggt cacaacatcg acatcatgac cttcaatcaa 
                 600 
               
               
                   
               
               
                 tctagatacc caagaatctt gaaggattct ttgttgccag ctccaaaatc tgccaactct 
                 660 
               
               
                   
               
               
                 caaatttctg attggtatcc accaggtcat ggtgacgttt ttgaatcctt gtacaactct 
                 720 
               
               
                   
               
               
                 ggtatcttgg ataagttgtt ggaaagaggt gtcgaaatcg ttttcttgtc caatgctgat 
                 780 
               
               
                   
               
               
                 aatttgggtg ccgttgttga tttgaagatc ttgcaacata tggttgatac caaggccgaa 
                 840 
               
               
                   
               
               
                 tatatcatgg aattgactga taagactaag gccgatgtta agggtggtac tattattgac 
                 900 
               
               
                   
               
               
                 tatgaaggtc aagccagatt attggaaatt gcccaagttc caaaagaaca cgtcaacgaa 
                 960 
               
               
                   
               
               
                 ttcaagtcca tcaagaagtt taagtacttc aacaccaaca acatctggat gaacttgaga 
                 1020 
               
               
                   
               
               
                 gctgttaaga gaatcgtcga aaacaacgaa ttggccatgg aaattatccc aaacggtaaa 
                 1080 
               
               
                   
               
               
                 tctattccag ccgacaaaaa aggtgaagcc gatgtttcta tagttcaatt ggaaactgct 
                 1140 
               
               
                   
               
               
                 gttggtgctg ccattagaca ttttaacaat gctcatggtg tcaacgtccc aagaagaaga 
                 1200 
               
               
                   
               
               
                 tttttgccag ttaagacctg ctccgatttg atgttggtta agtctgactt gtacactttg 
                 1260 
               
               
                   
               
               
                 aagcacggtc aattgattat ggacccaaat agatttggtc cagccccatt gattaagttg 
                 1320 
               
               
                   
               
               
                 ggtggtgatt ttaagaaggt ttcctcattc caatccagaa tcccatccat tcctaaaatc 
                 1380 
               
               
                   
               
               
                 ttggaattgg atcatttgac cattaccggt ccagttaact tgggtagagg tgttactttt 
                 1440 
               
               
                   
               
               
                 aagggtactg ttattatcgt tgcctccgaa ggtcaaacca ttgatattcc acctggttcc 
                 1500 
               
               
                   
               
               
                 attttggaaa acgttgttgt tcaaggttcc ttgagattat tagaacatta a 
                 1551 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 127 
               
               
                 
                   A. pullulans 
                 
               
            
           
           
               
               
            
               
                 MSSEMATHLK PNGGAEFEKR HHGKTQSHVA FENTSTSVAA SQMRNALNTL CDSVTDPAEK 
                 60 
               
               
                   
               
               
                 QRFETEMDNF FALFRRYLND KAKGNEIEWS RIAPPKPEQV VAYQDLPEQE SVEFLNKLAV 
                 120 
               
               
                   
               
               
                 LKLNGGLGTS MGCVGPKSVI EVRDGMSFLD LSVRQIEYLN RTYGVNVPFV LMNSFNTDAD 
                 180 
               
               
                   
               
               
                 TANIIKKYEG HNIDIMTFNQ SRYPRILKDS LLPAPKSANS QISDWYPPGH GDVFESLYNS 
                 240 
               
               
                   
               
               
                 GILDKLLERG VEIVFLSNAD NLGAVVDLKI LQHMVDTKAE YIMELTDKTK ADVKGGTIID 
                 300 
               
               
                   
               
               
                 YEGQARLLEI AQVPKEHVNE FKSIKKFKYF NTNNIWMNLR AVKRIVENNE LAMEIIPNGK 
                 360 
               
               
                   
               
               
                 SIPADKKGEA DVSIVQLETA VGAAIRHFNN AHGVNVPRRR FLPVKTCSDL MLVKSDLYTL 
                 420 
               
               
                   
               
               
                 KHGQLIMDPN RFGPAPLIKL GGDFKKVSSF QSRIPSIPKI LELDHLTITG PVNLGRGVTF 
                 480 
               
               
                   
               
               
                 KGTVIIVASE GQTIDIPPGS ILENVVVQGS LRLLEH 
                 516 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 128 
               
               
                 
                   A. thaliana 
                 
               
            
           
           
               
               
            
               
                 atggctgcta ctactgaaaa cttgccacaa ttgaaatctg ccgttgatgg tttgactgaa 
                 60 
               
               
                   
               
               
                 atgtccgaat ctgaaaagtc cggtttcatc tctttggtca gtagatattt gtctggtgaa 
                 120 
               
               
                   
               
               
                 gcccaacata tcgaatggtc taaaattcaa actccaaccg acgaaatcgt tgtcccatac 
                 180 
               
               
                   
               
               
                 gaaaaaatga ctccagtttc tcaagatgtc gccgaaacta agaatttgtt ggataagttg 
                 240 
               
               
                   
               
               
                 gtcgtcttga agttgaatgg tggtttgggt actactatgg gttgtactgg tccaaagtct 
                 300 
               
               
                   
               
               
                 gttatcgaag ttagagatgg tttaaccttc ttggacttga tcgtcatcca aatcgaaaac 
                 360 
               
               
                   
               
               
                 ttgaacaaca agtacggttg caaggttcca ttggtcttga tgaattcttt caacacccat 
                 420 
               
               
                   
               
               
                 gatgataccc acaagatcgt tgaaaagtac accaactcca acgttgatat ccacaccttc 
                 480 
               
               
                   
               
               
                 aatcaatcta agtacccaag agttgttgcc gatgaatttg ttccatggcc atctaaaggt 
                 540 
               
               
                   
               
               
                 aagactgaca aagaaggttg gtatccacca ggtcatggtg atgtttttcc agctttaatg 
                 600 
               
               
                   
               
               
                 aactccggta agttggatac tttcttgtcc caaggtaaag aatacgtttt cgttgccaac 
                 660 
               
               
                   
               
               
                 tctgataact tgggtgctat agttgatttg accatcttga agcacttgat ccaaaacaag 
                 720 
               
               
                   
               
               
                 aacgaatact gcatggaagt tactccaaag actttggctg atgttaaggg tggtactttg 
                 780 
               
               
                   
               
               
                 atttcttacg aaggtaaggt tcaattattg gaaatcgccc aagttccaga tgaacacgtt 
                 840 
               
               
                   
               
               
                 aatgaattca agtccatcga aaagttcaag atcttcaaca ccaacaactt gtgggttaac 
                 900 
               
               
                   
               
               
                 ttgaaggcca tcaagaaatt ggttgaagct gatgctttga agatggaaat tatcccaaac 
                 960 
               
               
                   
               
               
                 ccaaaagaag ttgacggtgt taaggtattg caattggaaa ctgctgctgg tgctgctatt 
                 1020 
               
               
                   
               
               
                 agatttttcg ataatgccat cggtgttaac gtcccaagat ctagattttt gccagttaag 
                 1080 
               
               
                   
               
               
                 gcttcctccg atttgttgtt ggttcaatct gacttgtaca ccttggttga cggttttgtt 
                 1140 
               
               
                   
               
               
                 acaagaaaca aggctagaac taacccatcc aacccatcta ttgaattggg tccagaattc 
                 1200 
               
               
                   
               
               
                 aaaaaggttg ccacattctt gtccagattc aagtctattc catccatcgt cgaattggac 
                 1260 
               
               
                   
               
               
                 tcattgaaag tttctggtga tgtctggttt ggttcctcta tagttttgaa gggtaaggtt 
                 1320 
               
               
                   
               
               
                 actgttgctg ctaaatctgg tgttaagttg gaaattccag atagagccgt tgtcgaaaac 
                 1380 
               
               
                   
               
               
                 aaaaacatta acggtcctga agatttgtga 
                 1410 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 129 
               
               
                 
                   A. thaliana 
                 
               
            
           
           
               
               
            
               
                 MAATTENLPQ LKSAVDGLTE MSESEKSGFI SLVSRYLSGE AQHIEWSKIQ TPTDEIVVPY 
                 60 
               
               
                   
               
               
                 EKMTPVSQDV AETKNLLDKL VVLKLNGGLG TTMGCTGPKS VIEVRDGLTF LDLIVIQIEN 
                 120 
               
               
                   
               
               
                 LNNKYGCKVP LVLMNSFNTH DDTHKIVEKY TNSNVDIHTF NQSKYPRVVA DEFVPWPSKG 
                 180 
               
               
                   
               
               
                 KTDKEGWYPP GHGDVFPALM NSGKLDTFLS QGKEYVFVAN SDNLGAIVDL TILKHLIQNK 
                 240 
               
               
                   
               
               
                 NEYCMEVTPK TLADVKGGTL ISYEGKVQLL EIAQVPDEHV NEFKSIEKFK IFNTNNLWVN 
                 300 
               
               
                   
               
               
                 LKAIKKLVEA DALKMEIIPN PKEVDGVKVL QLETAAGAAI RFFDNAIGVN VPRSRFLPVK 
                 360 
               
               
                   
               
               
                 ASSDLLLVQS DLYTLVDGFV TRNKARTNPS NPSIELGPEF KKVATFLSRF KSIPSIVELD 
                 420 
               
               
                   
               
               
                 SLKVSGDVWF GSSIVLKGKV TVAAKSGVKL EIPDRAVVEN KNINGPEDL 
                 469 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 130 
               
               
                 
                   E. coli 
                 
               
            
           
           
               
               
            
               
                 atggctgcta ttaacaccaa ggttaagaag gctgttattc cagttgctgg tttgggtact 
                 60 
               
               
                   
               
               
                 agaatgttgc cagctacaaa agccattcca aaagaaatgt taccattggt cgataagcca 
                 120 
               
               
                   
               
               
                 ttgatccaat acgttgtcaa cgaatgtatt gctgctggta ttaccgaaat cgttttggtt 
                 180 
               
               
                   
               
               
                 actcactcct ccaagaactc cattgaaaat catttcgaca cctcattcga attggaagcc 
                 240 
               
               
                   
               
               
                 atgttggaaa agagagtcaa gagacaatta ttggacgaag tccaatctat ttgcccacca 
                 300 
               
               
                   
               
               
                 catgttacta tcatgcaagt tagacaaggt ttggctaaag gtttgggtca tgctgttttg 
                 360 
               
               
                   
               
               
                 tgtgctcatc cagttgttgg tgatgaacca gttgcagtta ttttgccaga tgttatcttg 
                 420 
               
               
                   
               
               
                 gacgaatacg aatccgattt gtctcaagat aacttggctg aaatgatcag aagattcgac 
                 480 
               
               
                   
               
               
                 gaaactggtc actcccaaat tatggttgaa cctgttgctg atgttactgc ttatggtgtt 
                 540 
               
               
                   
               
               
                 gttgattgca agggtgttga attggctcca ggtgaatctg ttccaatggt tggtgttgta 
                 600 
               
               
                   
               
               
                 gaaaagccaa aagctgatgt tgctccatct aatttggcta tcgttggtag atatgttttg 
                 660 
               
               
                   
               
               
                 tccgctgata tttggccttt gttggctaaa actccaccag gtgctggtga cgaaattcaa 
                 720 
               
               
                   
               
               
                 ttgactgatg ctatcgacat gttgatcgaa aaagaaaccg ttgaagccta ccacatgaag 
                 780 
               
               
                   
               
               
                 ggtaaatctc atgattgtgg taacaagttg ggttacatgc aagcttttgt tgaatacggt 
                 840 
               
               
                   
               
               
                 atcagacata acaccttagg tactgaattc aaggcttggt tggaagaaga aatgggtatc 
                 900 
               
               
                   
               
               
                 aagaagtaa 
                 909 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 131 
               
               
                 
                   E. coli 
                 
               
            
           
           
               
               
            
               
                 MAAINTKVKK AVIPVAGLGT RMLPATKAIP KEMLPLVDKP LIQYVVNECI AAGITEIVLV 
                 60 
               
               
                   
               
               
                 THSSKNSIEN HFDTSFELEA MLEKRVKRQL LDEVQSICPP HVTIMQVRQG LAKGLGHAVL 
                 120 
               
               
                   
               
               
                 CAHPVVGDEP VAVILPDVIL DEYESDLSQD NLAEMIRRFD ETGHSQIMVE PVADVTAYGV 
                 180 
               
               
                   
               
               
                 VDCKGVELAP GESVPMVGVV EKPKADVAPS NLAIVGRYVL SADIWPLLAK TPPGAGDEIQ 
                 240 
               
               
                   
               
               
                 LTDAIDMLIE KETVEAYHMK GKSHDCGNKL GYMQAFVEYG IRHNTLGTEF KAWLEEEMGI 
                 300 
               
               
                   
               
               
                 KK 
                 302 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 132 
               
               
                 
                   R. suavissimus 
                 
               
            
           
           
               
               
            
               
                 atggctgctg ttgctactga taagatctct aagttgaagt ctgaagttgc tgccttgtcc 
                 60 
               
               
                   
               
               
                 caaatttctg aaaacgaaaa gtccggtttc atcaacttgg tcagtagata tttgtctggt 
                 120 
               
               
                   
               
               
                 actgaagcta ctcacgttga atggtctaaa attcaaactc caaccgatga agttgttgtt 
                 180 
               
               
                   
               
               
                 ccatatgata ctttggctcc aactccagaa gatccagctg aaactaagaa gttgttagat 
                 240 
               
               
                   
               
               
                 aagttggtcg tcttgaagtt gaacggtggt ttgggtacta ctatgggttg tactggtcca 
                 300 
               
               
                   
               
               
                 aagtctgtta tcgaagttag aaacggtttg accttcttgg atttgatcgt cattcaaatc 
                 360 
               
               
                   
               
               
                 gaaaccttga acaacaagta cggttgtaac gttcctttgt tgttgatgaa ctctttcaac 
                 420 
               
               
                   
               
               
                 acccatgatg acaccttcaa gatcgttgaa agatacacca agtccaacgt tcaaatccat 
                 480 
               
               
                   
               
               
                 accttcaatc aatcccaata cccaagattg gttgtcgaag ataattctcc attgccatct 
                 540 
               
               
                   
               
               
                 aagggtcaaa ctggtaaaga tggttggtat ccaccaggtc atggtgatgt ttttccatct 
                 600 
               
               
                   
               
               
                 ttgagaaact ccggtaagtt ggatttgttg ttatcccaag gtaaagaata cgttttcatc 
                 660 
               
               
                   
               
               
                 tccaactctg ataacttggg tgcagttgtt gatttgaaga tcttgtccca tttggtccaa 
                 720 
               
               
                   
               
               
                 aaaaagaacg aatactgcat ggaagttacc ccaaaaactt tggctgatgt taagggtggt 
                 780 
               
               
                   
               
               
                 actttgattt cttacgaagg tagaacccaa ttattggaaa ttgcccaagt tccagatcaa 
                 840 
               
               
                   
               
               
                 cacgttaacg aattcaagtc catcgaaaag ttcaagatct ttaacaccaa caatttgtgg 
                 900 
               
               
                   
               
               
                 gtcaacttga acgccattaa gagattagtt gaagctgatg ccttgaaaat ggaaatcatc 
                 960 
               
               
                   
               
               
                 ccaaatccaa aagaagtcga cggtattaag gtcttgcaat tggaaactgc tgctggtgct 
                 1020 
               
               
                   
               
               
                 gctattagat ttttcaatca tgccatcggt atcaacgtcc caagatctag atttttgcca 
                 1080 
               
               
                   
               
               
                 gttaaggcta cctccgattt gttattggtt caatctgact tgtacaccgt cgaagatggt 
                 1140 
               
               
                   
               
               
                 ttcgttatta gaaacactgc tagaaagaat ccagccaacc catctgttga attgggtcca 
                 1200 
               
               
                   
               
               
                 gaattcaaaa aggttgccaa cttcttgtcc agattcaagt ctattccatc catcatcgaa 
                 1260 
               
               
                   
               
               
                 ttggactcat tgaaggttgt tggtgatgta tggtttggtg ctggtgttgt tttgaaaggt 
                 1320 
               
               
                   
               
               
                 aaggttacta ttactgctaa gccaggtgtt aagttggaaa ttccagataa ggctgtcttg 
                 1380 
               
               
                   
               
               
                 gaaaacaagg atattaacgg tcctgaagat ttgtga 
                 1416 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 133 
               
               
                 
                   R. suavissimus 
                 
               
            
           
           
               
               
            
               
                 MAAVATDKIS KLKSEVAALS QISENEKSGF INLVSRYLSG TEATHVEWSK IQTPTDEVVV 
                 60 
               
               
                   
               
               
                 PYDTLAPTPE DPAETKKLLD KLVVLKLNGG LGTTMGCTGP KSVIEVRNGL TFLDLIVIQI 
                 120 
               
               
                   
               
               
                 ETLNNKYGCN VPLLLMNSFN THDDTFKIVE RYTKSNVQIH TFNQSQYPRL VVEDNSPLPS 
                 180 
               
               
                   
               
               
                 KGQTGKDGWY PPGHGDVFPS LRNSGKLDLL LSQGKEYVFI SNSDNLGAVV DLKILSHLVQ 
                 240 
               
               
                   
               
               
                 KKNEYCMEVT PKTLADVKGG TLISYEGRTQ LLEIAQVPDQ HVNEFKSIEK FKIFNTNNLW 
                 300 
               
               
                   
               
               
                 VNLNAIKRLV EADALKMEII PNPKEVDGIK VLQLETAAGA AIRFFNHAIG INVPRSRFLP 
                 360 
               
               
                   
               
               
                 VKATSDLLLV QSDLYTVEDG FVIRNTARKN PANPSVELGP EFKKVANFLS RFKSIPSIIE 
                 420 
               
               
                   
               
               
                 LDSLKVVGDV WFGAGVVLKG KVTITAKPGV KLEIPDKAVL ENKDINGPED L 
                 471 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 134 
               
               
                 
                   H. vulgare 
                 
               
            
           
           
               
               
            
               
                 atggctgctg ctgcagttgc tgctgattct aaaattgatg gtttgagaga tgctgttgcc 
                 60 
               
               
                   
               
               
                 aagttgggtg aaatttctga aaacgaaaag gccggtttca tctccttggt ttctagatat 
                 120 
               
               
                   
               
               
                 ttgtctggtg aagccgaaca aatcgaatgg tctaaaattc aaactccaac cgatgaagtt 
                 180 
               
               
                   
               
               
                 gttgttccat atgatacttt ggctccacca cctgaagatt tggatgctat gaaggctttg 
                 240 
               
               
                   
               
               
                 ttggataagt tggttgtctt gaagttgaat ggtggtttgg gtactactat gggttgtact 
                 300 
               
               
                   
               
               
                 ggtccaaagt ctgttatcga agttagaaac ggtttcacct tcttggattt gatcgttatc 
                 360 
               
               
                   
               
               
                 caaattgaat ccttgaacaa gaagtacggt tgctctgttc ctttgttgtt gatgaactct 
                 420 
               
               
                   
               
               
                 ttcaacaccc atgatgacac ccaaaagatc gttgaaaagt actccaactc caacatcgaa 
                 480 
               
               
                   
               
               
                 atccacacct tcaatcaatc tcaataccca agaatcgtca ccgaagattt tttgccattg 
                 540 
               
               
                   
               
               
                 ccatctaaag gtcaaactgg taaagatggt tggtatccac caggtcatgg tgatgttttt 
                 600 
               
               
                   
               
               
                 ccatctttga acaactccgg taagttggat accttgttgt ctcaaggtaa agaatacgtt 
                 660 
               
               
                   
               
               
                 ttcgttgcca actctgataa cttgggtgct atcgttgata ttaagatctt gaaccacttg 
                 720 
               
               
                   
               
               
                 atccacaatc aaaacgaata ctgcatggaa gttactccaa agactttggc tgatgttaag 
                 780 
               
               
                   
               
               
                 ggtggtactt tgatttctta cgaaggtaga gttcaattat tggaaatcgc ccaagttcca 
                 840 
               
               
                   
               
               
                 gatgaacacg ttgatgaatt caagtccatc gaaaagttca aaatcttcaa caccaacaac 
                 900 
               
               
                   
               
               
                 ttgtgggtta acttgaaggc cattaagaga ttggttgatg ctgaagcttt gaaaatggaa 
                 960 
               
               
                   
               
               
                 atcatcccaa accctaaaga agttgacggt gttaaggtat tgcaattgga aactgctgct 
                 1020 
               
               
                   
               
               
                 ggtgctgcta ttagattctt tgaaaaagcc atcggtatca acgtcccaag atctagattt 
                 1080 
               
               
                   
               
               
                 ttgccagtta aggctacctc tgacttgttg ttggttcaat cagacttgta caccttggtt 
                 1140 
               
               
                   
               
               
                 gacggttacg ttattagaaa tccagctaga gttaagccat ccaacccatc tattgaattg 
                 1200 
               
               
                   
               
               
                 ggtccagaat tcaagaaggt cgctaatttc ttggctagat tcaagtctat cccatccatc 
                 1260 
               
               
                   
               
               
                 gttgaattgg actcattgaa agtttctggt gatgtctctt ttggttccgg tgttgttttg 
                 1320 
               
               
                   
               
               
                 aagggtaatg ttactattgc tgctaaggct ggtgttaagt tggaaattcc agatggtgct 
                 1380 
               
               
                   
               
               
                 gttttggaaa acaaggatat taacggtcca gaagatattt ga 
                 1422 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 135 
               
               
                 
                   H. vulgare 
                 
               
            
           
           
               
               
            
               
                 MAAAAVAADS KIDGLRDAVA KLGEISENEK AGFISLVSRY LSGEAEQIEW SKIQTPTDEV 
                 60 
               
               
                   
               
               
                 VVPYDTLAPP PEDLDAMKAL LDKLVVLKLN GGLGTTMGCT GPKSVIEVRN GFTFLDLIVI 
                 120 
               
               
                   
               
               
                 QIESLNKKYG CSVPLLLMNS FNTHDDTQKI VEKYSNSNIE IHTFNQSQYP RIVTEDFLPL 
                 180 
               
               
                   
               
               
                 PSKGQTGKDG WYPPGHGDVF PSLNNSGKLD TLLSQGKEYV FVANSDNLGA IVDIKILNHL 
                 240 
               
               
                   
               
               
                 IHNQNEYCME VTPKTLADVK GGTLISYEGR VQLLEIAQVP DEHVDEFKSI EKFKIFNTNN 
                 300 
               
               
                   
               
               
                 LWVNLKAIKR LVDAEALKME IIPNPKEVDG VKVLQLETAA GAAIRFFEKA IGINVPRSRF 
                 360 
               
               
                   
               
               
                 LPVKATSDLL LVQSDLYTLV DGYVIRNPAR VKPSNPSIEL GPEFKKVANF LARFKSIPSI 
                 420 
               
               
                   
               
               
                 VELDSLKVSG DVSFGSGVVL KGNVTIAAKA GVKLEIPDGA VLENKDINGP EDI 
                 473 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 136 
               
               
                 
                   O. sativa 
                 
               
            
           
           
               
               
            
               
                 atggctgacg aaaaattggc caaattgaga gaagctgttg ctggtttgtc tcaaatctct 
                 60 
               
               
                   
               
               
                 gataacgaaa agtccggttt catttccttg gttgctagat atttgtccgg tgaagaagaa 
                 120 
               
               
                   
               
               
                 catgttgaat gggctaaaat tcatacccca accgatgaag ttgttgttcc atatgatact 
                 180 
               
               
                   
               
               
                 ttggaagctc caccagaaga tttggaagaa acaaaaaagt tgttgaacaa gttggccgtc 
                 240 
               
               
                   
               
               
                 ttgaagttga atggtggttt gggtactact atgggttgta ctggtccaaa gtctgttatc 
                 300 
               
               
                   
               
               
                 gaagttagaa acggtttcac cttcttggat ttgatcgtca tccaaatcga atccttgaac 
                 360 
               
               
                   
               
               
                 aaaaagtacg gttccaacgt tcctttgttg ttgatgaact ctttcaacac ccatgaagat 
                 420 
               
               
                   
               
               
                 accttgaaga tcgttgaaaa gtacaccaac tccaacatcg aagttcacac cttcaatcaa 
                 480 
               
               
                   
               
               
                 tctcaatacc caagagttgt tgccgatgaa tttttgccat ggccatctaa aggtaagact 
                 540 
               
               
                   
               
               
                 tgtaaagatg gttggtatcc accaggtcat ggtgatattt ttccatcctt gatgaacagt 
                 600 
               
               
                   
               
               
                 ggtaagttgg acttgttgtt gtcccaaggt aaagaatacg ttttcattgc caactccgat 
                 660 
               
               
                   
               
               
                 aacttgggtg ctatagttga tatgaagatt ttgaaccact tgatccacaa gcaaaacgaa 
                 720 
               
               
                   
               
               
                 tactgtatgg aagttactcc aaagactttg gctgatgtta agggtggtac tttgatctct 
                 780 
               
               
                   
               
               
                 tacgaagata aggttcaatt attggaaatc gcccaagttc cagatgctca tgttaatgaa 
                 840 
               
               
                   
               
               
                 ttcaagtcca tcgaaaagtt caagatcttt aacaccaaca acttgtgggt taacttgaag 
                 900 
               
               
                   
               
               
                 gccattaaga gattagttga agctgacgct ttgaagatgg aaattatccc aaacccaaaa 
                 960 
               
               
                   
               
               
                 gaagttgacg gtgttaaggt attgcaattg gaaactgctg ctggtgctgc tattagattt 
                 1020 
               
               
                   
               
               
                 ttcgatcatg ctatcggtat caacgtccca agatctagat ttttaccagt taaggctacc 
                 1080 
               
               
                   
               
               
                 tccgacttgc aattagttca atctgacttg tacaccttgg ttgatggttt cgttactaga 
                 1140 
               
               
                   
               
               
                 aatccagcta gaactaatcc atccaaccca tctattgaat tgggtccaga attcaagaag 
                 1200 
               
               
                   
               
               
                 gttggttgtt ttttgggtag attcaagtct atcccatcca tcgttgaatt ggacactttg 
                 1260 
               
               
                   
               
               
                 aaagtttctg gtgatgtttg gttcggttcc tccattacat tgaaaggtaa ggttactatt 
                 1320 
               
               
                   
               
               
                 accgctcaac caggtgttaa gttggaaatt ccagatggtg ctgtcatcga aaacaaggat 
                 1380 
               
               
                   
               
               
                 attaacggtc ctgaagattt gtga 
                 1404 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 137 
               
               
                 
                   O. sativa 
                 
               
            
           
           
               
               
            
               
                 MADEKLAKLR EAVAGLSQIS DNEKSGFISL VARYLSGEEE HVEWAKIHTP TDEVVVPYDT 
                 60 
               
               
                   
               
               
                 LEAPPEDLEE TKKLLNKLAV LKLNGGLGTT MGCTGPKSVI EVRNGFTFLD LIVIQIESLN 
                 120 
               
               
                   
               
               
                 KKYGSNVPLL LMNSFNTHED TLKIVEKYTN SNIEVHTFNQ SQYPRVVADE FLPWPSKGKT 
                 180 
               
               
                   
               
               
                 CKDGWYPPGH GDIFPSLMNS GKLDLLLSQG KEYVFIANSD NLGAIVDMKI LNHLIHKQNE 
                 240 
               
               
                   
               
               
                 YCMEVTPKTL ADVKGGTLIS YEDKVQLLEI AQVPDAHVNE FKSIEKFKIF NTNNLWVNLK 
                 300 
               
               
                   
               
               
                 AIKRLVEADA LKMEIIPNPK EVDGVKVLQL ETAAGAAIRF FDHAIGINVP RSRFLPVKAT 
                 360 
               
               
                   
               
               
                 SDLQLVQSDL YTLVDGFVTR NPARTNPSNP SIELGPEFKK VGCFLGRFKS IPSIVELDTL 
                 420 
               
               
                   
               
               
                 KVSGDVWFGS SITLKGKVTI TAQPGVKLEI PDGAVIENKD INGPEDL 
                 467 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 138 
               
               
                 
                   S. tuberosum 
                 
               
            
           
           
               
               
            
               
                 atggctactg ctactacttt gtctccagct gatgctgaaa agttgaacaa tttgaaatct 
                 60 
               
               
                   
               
               
                 gctgtcgccg gtttgaatca aatctctgaa aacgaaaagt ccggtttcat caacttggtt 
                 120 
               
               
                   
               
               
                 ggtagatatt tgtctggtga agcccaacat attgactggt ctaaaattca aactccaacc 
                 180 
               
               
                   
               
               
                 gatgaagttg ttgtcccata tgataagttg gctccattgt ctgaagatcc agctgaaaca 
                 240 
               
               
                   
               
               
                 aaaaagttgt tggacaagtt ggtcgtcttg aagttgaatg gtggtttggg tactactatg 
                 300 
               
               
                   
               
               
                 ggttgtactg gtccaaagtc tgttatcgaa gttagaaacg gtttgacctt cttggatttg 
                 360 
               
               
                   
               
               
                 atcgtcaagc aaattgaagc tttgaacgct aagttcggtt gttctgttcc tttgttgttg 
                 420 
               
               
                   
               
               
                 atgaactctt tcaacaccca tgatgacacc ttgaagatcg ttgaaaagta cgccaactcc 
                 480 
               
               
                   
               
               
                 aacattgata tccacacctt caatcaatcc caatacccaa gattggttac cgaagatttt 
                 540 
               
               
                   
               
               
                 gctccattgc catgtaaagg taactctggt aaagatggtt ggtatccacc aggtcatggt 
                 600 
               
               
                   
               
               
                 gatgtttttc catccttgat gaattccggt aagttggatg ctttgttggc taagggtaaa 
                 660 
               
               
                   
               
               
                 gaatacgttt tcgttgccaa ctctgataac ttgggtgcta tcgttgattt gaaaatcttg 
                 720 
               
               
                   
               
               
                 aaccacttga tcttgaacaa gaacgaatac tgcatggaag ttactccaaa gactttggct 
                 780 
               
               
                   
               
               
                 gatgttaagg gtggtacttt gatttcttac gaaggtaagg ttcaattatt ggaaatcgcc 
                 840 
               
               
                   
               
               
                 caagttccag atgaacacgt taatgaattc aagtccatcg aaaagtttaa gatcttcaac 
                 900 
               
               
                   
               
               
                 actaacaact tgtgggtcaa cttgtctgcc attaagagat tggttgaagc tgatgccttg 
                 960 
               
               
                   
               
               
                 aaaatggaaa ttattccaaa cccaaaagaa gtcgatggtg tcaaagtatt gcaattggaa 
                 1020 
               
               
                   
               
               
                 actgctgctg gtgctgctat taagtttttc gatagagcta ttggtgccaa cgttccaaga 
                 1080 
               
               
                   
               
               
                 tctagatttt tgccagttaa ggctacctct gacttgttgt tggttcaatc agacttgtac 
                 1140 
               
               
                   
               
               
                 actttgactg atgaaggtta cgttattaga aacccagcta gatccaatcc atccaaccca 
                 1200 
               
               
                   
               
               
                 tctattgaat tgggtccaga attcaagaag gtagccaatt ttttgggtag attcaagtct 
                 1260 
               
               
                   
               
               
                 atcccatcca tcatcgattt ggattctttg aaagttactg gtgatgtctg gtttggttct 
                 1320 
               
               
                   
               
               
                 ggtgttactt tgaaaggtaa agttaccgtt gctgctaagt caggtgttaa gttggaaatt 
                 1380 
               
               
                   
               
               
                 ccagatggtg ctgttattgc caacaaggat attaacggtc cagaagatat ctaa 
                 1434 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 139 
               
               
                 
                   S. tuberosum 
                 
               
            
           
           
               
               
            
               
                 MATATTLSPA DAEKLNNLKS AVAGLNQISE NEKSGFINLV GRYLSGEAQH IDWSKIQTPT 
                 60 
               
               
                   
               
               
                 DEVVVPYDKL APLSEDPAET KKLLDKLVVL KLNGGLGTTM GCTGPKSVIE VRNGLTFLDL 
                 120 
               
               
                   
               
               
                 IVKQIEALNA KFGCSVPLLL MNSFNTHDDT LKIVEKYANS NIDIHTFNQS QYPRLVTEDF 
                 180 
               
               
                   
               
               
                 APLPCKGNSG KDGWYPPGHG DVFPSLMNSG KLDALLAKGK EYVFVANSDN LGAIVDLKIL 
                 240 
               
               
                   
               
               
                 NHLILNKNEY CMEVTPKTLA DVKGGTLISY EGKVQLLEIA QVPDEHVNEF KSIEKFKIFN 
                 300 
               
               
                   
               
               
                 TNNLWVNLSA IKRLVEADAL KMEIIPNPKE VDGVKVLQLE TAAGAAIKFF DRAIGANVPR 
                 360 
               
               
                   
               
               
                 SRFLPVKATS DLLLVQSDLY TLTDEGYVIR NPARSNPSNP SIELGPEFKK VANFLGRFKS 
                 420 
               
               
                   
               
               
                 IPSIIDLDSL KVTGDVWFGS GVTLKGKVTV AAKSGVKLEI PDGAVIANKD INGPEDI 
                 477 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 140 
               
               
                 
                   A. thaliana 
                 
               
            
           
           
               
               
            
               
                 atgttcttgt tggttacctc ttgcttcttg ccagattctg gttcttctgt taaggtcagt 
                 60 
               
               
                   
               
               
                 ttgttcatct tcggtgtctc attggtttct acctctccaa ttgatggtca aaaaccaggt 
                 120 
               
               
                   
               
               
                 acttctggtt tgagaaagaa ggtcaaggtt ttcaagcaac ctaactactt ggaaaacttc 
                 180 
               
               
                   
               
               
                 gttcaagcta ctttcaacgc tttgactacc gaaaaagtta agggtgctac tttggttgtt 
                 240 
               
               
                   
               
               
                 tctggtgatg gtagatatta ctccgaacaa gccattcaaa tcatcgttaa gatggctgct 
                 300 
               
               
                   
               
               
                 gctaacggtg ttagaagagt ttgggttggt caaaactctt tgttgtctac tccagctgtt 
                 360 
               
               
                   
               
               
                 tccgccatta ttagagaaag agttggtgct gatggttcta aagctactgg tgctttcatt 
                 420 
               
               
                   
               
               
                 ttgactgctt ctcataatcc aggtggtcca actgaagatt tcggtattaa gtacaacatg 
                 480 
               
               
                   
               
               
                 gaaaatggtg gtccagcccc agaatctatt actgataaga tatacgaaaa caccaagacc 
                 540 
               
               
                   
               
               
                 atcaaagaat acccaattgc agaagatttg ccaagagttg atatctctac tatcggtatc 
                 600 
               
               
                   
               
               
                 acttctttcg aaggtcctga aggtaaattc gacgttgaag tttttgattc cgctgatgat 
                 660 
               
               
                   
               
               
                 tacgtcaagt tgatgaagtc catcttcgac ttcgaatcca tcaagaagtt gttgtcttac 
                 720 
               
               
                   
               
               
                 ccaaagttca ccttttgtta cgatgcattg catggtgttg ctggtgctta tgctcataga 
                 780 
               
               
                   
               
               
                 attttcgttg aagaattggg tgctccagaa tcctctttat tgaactgtgt tccaaaagaa 
                 840 
               
               
                   
               
               
                 gattttggtg gtggtcatcc agatccaaat ttgacttatg ccaaagaatt ggttgccaga 
                 900 
               
               
                   
               
               
                 atgggtttgt ctaagactga tgatgctggt ggtgaaccac ctgaatttgg tgctgctgca 
                 960 
               
               
                   
               
               
                 gatggtgatg ctgatagaaa tatgatcttg ggtaaaagat tcttcgtcac cccatctgat 
                 1020 
               
               
                   
               
               
                 tccgttgcta ttattgctgc taatgctgtt ggtgctattc catacttttc atccggtttg 
                 1080 
               
               
                   
               
               
                 aaaggtgttg ctagatctat gccaacttct gctgctttgg atgttgttgc taagaatttg 
                 1140 
               
               
                   
               
               
                 ggtttgaagt tcttcgaagt tccaactggt tggaaattct tcggtaattt gatggatgca 
                 1200 
               
               
                   
               
               
                 ggtatgtgtt ctgtttgcgg tgaagaatca tttggtactg gttccgatca tatcagagaa 
                 1260 
               
               
                   
               
               
                 aaggatggta tttgggctgt tttggcttgg ttgtctattt tggctcacaa gaacaaagaa 
                 1320 
               
               
                   
               
               
                 accttggatg gtaatgccaa gttggttact gttgaagata tcgttagaca acattgggct 
                 1380 
               
               
                   
               
               
                 acttacggta gacattacta cactagatac gactacgaaa acgttgatgc tacagctgct 
                 1440 
               
               
                   
               
               
                 aaagaattga tgggtttatt ggtcaagttg caatcctcat tgccagaagt taacaagatc 
                 1500 
               
               
                   
               
               
                 atcaagggta tccatcctga agttgctaat gttgcttctg ctgatgaatt cgaatacaag 
                 1560 
               
               
                   
               
               
                 gatccagttg atggttccgt ttctaaacat caaggtatca gatacttgtt tgaagatggt 
                 1620 
               
               
                   
               
               
                 tccagattgg ttttcagatt gtctggtaca ggttctgaag gtgctactat tagattgtac 
                 1680 
               
               
                   
               
               
                 atcgaacaat acgaaaagga cgcctctaag attggtagag attctcaaga tgctttgggt 
                 1740 
               
               
                   
               
               
                 ccattggttg atgttgcttt gaagttgtcc aagatgcaag aattcactgg tagatcttct 
                 1800 
               
               
                   
               
               
                 ccaaccgtta ttacctga 
                 1818 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 141 
               
               
                 
                   A. thaliana 
                 
               
            
           
           
               
               
            
               
                 MFLLVTSCFL PDSGSSVKVS LFIFGVSLVS TSPIDGQKPG TSGLRKKVKV FKQPNYLENF 
                 60 
               
               
                   
               
               
                 VQATFNALTT EKVKGATLVV SGDGRYYSEQ AIQIIVKMAA ANGVRRVWVG QNSLLSTPAV 
                 120 
               
               
                   
               
               
                 SAIIRERVGA DGSKATGAFI LTASHNPGGP TEDFGIKYNM ENGGPAPESI TDKIYENTKT 
                 180 
               
               
                   
               
               
                 IKEYPIAEDL PRVDISTIGI TSFEGPEGKF DVEVFDSADD YVKLMKSIFD FESIKKLLSY 
                 240 
               
               
                   
               
               
                 PKFTFCYDAL HGVAGAYAHR IFVEELGAPE SSLLNCVPKE DFGGGHPDPN LTYAKELVAR 
                 300 
               
               
                   
               
               
                 MGLSKTDDAG GEPPEFGAAA DGDADRNMIL GKRFFVTPSD SVAIIAANAV GAIPYFSSGL 
                 360 
               
               
                   
               
               
                 KGVARSMPTS AALDVVAKNL GLKFFEVPTG WKFFGNLMDA GMCSVCGEES FGTGSDHIRE 
                 420 
               
               
                   
               
               
                 KDGIWAVLAW LSILAHKNKE TLDGNAKLVT VEDIVRQHWA TYGRHYYTRY DYENVDATAA 
                 480 
               
               
                   
               
               
                 KELMGLLVKL QSSLPEVNKI IKGIHPEVAN VASADEFEYK DPVDGSVSKH QGIRYLFEDG 
                 540 
               
               
                   
               
               
                 SRLVFRLSGT GSEGATIRLY IEQYEKDASK IGRDSQDALG PLVDVALKLS KMQEFTGRSS 
                 600 
               
               
                   
               
               
                 PTVIT 
                 605 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 142 
               
               
                 
                   E. coli 
                 
               
            
           
           
               
               
            
               
                 atggccattc ataatagagc tggtcaacca gcacaacaat ccgatttgat taacgttgct 
                 60 
               
               
                   
               
               
                 caattgaccg cccaatatta cgttttgaaa cctgaagctg gtaacgctga acatgctgtt 
                 120 
               
               
                   
               
               
                 aagtttggta cttctggtca tagaggttct gctgctagac attcttttaa cgaaccacat 
                 180 
               
               
                   
               
               
                 attttggcta tcgctcaagc tattgctgaa gaaagagcta agaacggtat tactggtcca 
                 240 
               
               
                   
               
               
                 tgttacgttg gtaaagatac ccatgctttg tctgaaccag ctttcatttc tgttttggaa 
                 300 
               
               
                   
               
               
                 gttttggctg ctaacggtgt tgatgttatc gttcaagaaa acaacggttt cactccaact 
                 360 
               
               
                   
               
               
                 ccagctgttt ctaatgctat tttggttcac aacaaaaagg gtggtccatt ggctgatggt 
                 420 
               
               
                   
               
               
                 atagttatta ctccatctca taacccacct gaagatggtg gtattaagta caatccacca 
                 480 
               
               
                   
               
               
                 aatggtggtc cagctgatac aaatgttact aaggttgttg aagatagagc caacgctttg 
                 540 
               
               
                   
               
               
                 ttagctgatg gtttgaaagg tgtcaagaga atctctttgg atgaagctat ggcttcaggt 
                 600 
               
               
                   
               
               
                 catgtcaaag aacaagattt ggttcaacca ttcgttgaag gtttggctga tatagttgat 
                 660 
               
               
                   
               
               
                 atggctgcta ttcaaaaggc tggtttgact ttgggtgttg atccattggg tggttctggt 
                 720 
               
               
                   
               
               
                 attgaatact ggaaaagaat cggtgaatat tacaacttga acttgaccat cgtcaacgat 
                 780 
               
               
                   
               
               
                 caagttgacc aaactttcag attcatgcac ttggataagg atggtgctat tagaatggac 
                 840 
               
               
                   
               
               
                 tgttcttctg aatgtgctat ggctggttta ttggctttga gagataagtt cgatttggct 
                 900 
               
               
                   
               
               
                 tttgctaacg atccagatta cgatagacat ggtatcgtta ctccagcagg tttgatgaat 
                 960 
               
               
                   
               
               
                 ccaaatcatt acttggctgt tgccatcaac tacttgtttc aacatagacc acaatggggt 
                 1020 
               
               
                   
               
               
                 aaggatgttg ctgttggtaa aactttggtt tcctccgcta tgatcgatag agttgttaac 
                 1080 
               
               
                   
               
               
                 gatttgggta gaaagttggt tgaagttcca gttggtttca agtggtttgt tgacggtttg 
                 1140 
               
               
                   
               
               
                 tttgatggtt cttttggttt tggtggtgaa gaatctgctg gtgcttcatt tttgagattt 
                 1200 
               
               
                   
               
               
                 gatggtactc catggtccac tgacaaagat ggtattatca tgtgtttgtt ggctgctgaa 
                 1260 
               
               
                   
               
               
                 attactgctg ttactggtaa gaatccacaa gaacactaca acgaattggc taagagattt 
                 1320 
               
               
                   
               
               
                 ggtgctccat cttacaatag attgcaagct gctgctactt ctgctcaaaa agctgcttta 
                 1380 
               
               
                   
               
               
                 tctaagttgt ccccagaaat ggtttctgct tctactttag ctggtgatcc aattacagct 
                 1440 
               
               
                   
               
               
                 agattgactg ctgctccagg taatggtgct tctattggtg gtttaaaggt tatgactgat 
                 1500 
               
               
                   
               
               
                 aacggttggt ttgctgcaag accatctggt actgaagatg cttacaaaat ctactgcgaa 
                 1560 
               
               
                   
               
               
                 tccttcttgg gtgaagaaca tagaaagcaa attgaaaaag aagccgtcga aatcgtcagt 
                 1620 
               
               
                   
               
               
                 gaagttttga agaatgccta a 
                 1641 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 143 
               
               
                 
                   E. coli 
                 
               
            
           
           
               
               
            
               
                 MAIHNRAGQP AQQSDLINVA QLTAQYYVLK PEAGNAEHAV KFGTSGHRGS AARHSFNEPH 
                 60 
               
               
                   
               
               
                 ILAIAQAIAE ERAKNGITGP CYVGKDTHAL SEPAFISVLE VLAANGVDVI VQENNGFTPT 
                 120 
               
               
                   
               
               
                 PAVSNAILVH NKKGGPLADG IVITPSHNPP EDGGIKYNPP NGGPADTNVT KVVEDRANAL 
                 180 
               
               
                   
               
               
                 LADGLKGVKR ISLDEAMASG HVKEQDLVQP FVEGLADIVD MAAIQKAGLT LGVDPLGGSG 
                 240 
               
               
                   
               
               
                 IEYWKRIGEY YNLNLTIVND QVDQTFRFMH LDKDGAIRMD CSSECAMAGL LALRDKFDLA 
                 300 
               
               
                   
               
               
                 FANDPDYDRH GIVTPAGLMN PNHYLAVAIN YLFQHRPQWG KDVAVGKTLV SSAMIDRVVN 
                 360 
               
               
                   
               
               
                 DLGRKLVEVP VGFKWFVDGL FDGSFGFGGE ESAGASFLRF DGTPWSTDKD GIIMCLLAAE 
                 420 
               
               
                   
               
               
                 ITAVTGKNPQ EHYNELAKRF GAPSYNRLQA AATSAQKAAL SKLSPEMVSA STLAGDPITA 
                 480 
               
               
                   
               
               
                 RLTAAPGNGA SIGGLKVMTD NGWFAARPSG TEDAYKIYCE SFLGEEHRKQ IEKEAVEIVS 
                 540 
               
               
                   
               
               
                 EVLKNA 
                 546 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 144 
               
               
                 
                   R. suavissimus 
                 
               
            
           
           
               
               
            
               
                 atgtcctccg gtaagattaa gagagttcaa actactccat tcgacggtca aaaaccaggt 
                 60 
               
               
                   
               
               
                 acttctggtt tgagaaagaa ggttaaggtt ttcacccaac ctaactactt gcaaaacttc 
                 120 
               
               
                   
               
               
                 gttcaatcta ccttcaacgc tttgccatct gataaggtaa aaggtgctag attggttgtt 
                 180 
               
               
                   
               
               
                 tctggtgatg gtagatactt ctccaaagaa gccattcaaa tcatcattaa gatggctgct 
                 240 
               
               
                   
               
               
                 ggtaacggtg ttaagtctgt ttgggttggt caaaatggtt tgttgtctac tccagctgtt 
                 300 
               
               
                   
               
               
                 tctgctgttg ttagagaaag agttggtgct gatggttgta aagcttctgg tgctttcatt 
                 360 
               
               
                   
               
               
                 ttgactgctt ctcataatcc aggtggtcca aatgaagatt tcggtatcaa gtacaacatg 
                 420 
               
               
                   
               
               
                 gaaaatggtg gtccagctcc agaatctatt accaacaaaa tctacgaaaa caccacccaa 
                 480 
               
               
                   
               
               
                 atcaaagaat acttgaccgt tgatttgcca gaagttgata ttactaagcc aggtgttact 
                 540 
               
               
                   
               
               
                 accttcgaag ttgaaggtgg tactttcact gttgatgttt tcgattctgc ttccgattac 
                 600 
               
               
                   
               
               
                 gtcaagttga tgaagtccat tttcgacttc gaatccatca gaaagttgtt gtcctctcca 
                 660 
               
               
                   
               
               
                 aagttcacct tttgttttga tgcattgcat ggtgttggtg gtgcttacgc taaaagaatt 
                 720 
               
               
                   
               
               
                 ttcgttgaag aattgggtgc caaagaatcc tctttgttga actgtgttcc taaagaagat 
                 780 
               
               
                   
               
               
                 tttggtggtg gtcatccaga tccaaatttg acatatgcta aagaattggt cgccagaatg 
                 840 
               
               
                   
               
               
                 ggtttgtcta agtctaatac tcaaaacgaa ccaccagaat ttggtgctgc tgcagatggt 
                 900 
               
               
                   
               
               
                 gatgctgata gaaatatggt tttgggtaag agattcttcg ttaccccatc tgattccgtt 
                 960 
               
               
                   
               
               
                 gctattattg ctgctaatgc tgttgaagct atcccatact tttctactgg tttgaaaggt 
                 1020 
               
               
                   
               
               
                 gttgctagat ctatgccaac ttctgctgct ttggatgttg ttgctaaaca cttgaacttg 
                 1080 
               
               
                   
               
               
                 aagttcttcg aagtaccaac tggttggaag tttttcggta atttgatgga tgctggtttg 
                 1140 
               
               
                   
               
               
                 tgttctgttt gcggtgaaga atcttttggt actggttccg atcatatcag agaaaaggat 
                 1200 
               
               
                   
               
               
                 ggtatttggg ctgttttggc ttggttgtca attattgcca tcaagaacaa ggataacatc 
                 1260 
               
               
                   
               
               
                 ggtggtgata agttggttac cgttgaagat atcgttagaa aacattgggc tacttacggt 
                 1320 
               
               
                   
               
               
                 agacattact acactagata cgattacgaa aacgttgatg ctggtaaggc taaagatttg 
                 1380 
               
               
                   
               
               
                 atggcatcat tggtcaactt gcaatcatct ttgcctgaag ttaacaagat cgttaagggt 
                 1440 
               
               
                   
               
               
                 atctgttccg atgttgcaaa tgttgttggt gccgatgaat tcgaatacaa ggattctgtt 
                 1500 
               
               
                   
               
               
                 gatggttcca tctccaaaca tcaaggtatc agatacttgt tcgaagatgg ttcaagattg 
                 1560 
               
               
                   
               
               
                 gttttcagat tgtctggtac aggttctgaa ggtgctacta ttagattgta catcgaacaa 
                 1620 
               
               
                   
               
               
                 tacgaaaatg acccatccaa gatctccaga gaatcttctg aagctttggc tccattggtt 
                 1680 
               
               
                   
               
               
                 gaagttgctt tgaaattgtc caagatgcaa gaattcactg gtagatcagc tccaactgtt 
                 1740 
               
               
                   
               
               
                 attacctga 
                 1749 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 145 
               
               
                 
                   R. suavissimus 
                 
               
            
           
           
               
               
            
               
                 MSSGKIKRVQ TTPFDGQKPG TSGLRKKVKV FTQPNYLQNF VQSTFNALPS DKVKGARLVV 
                 60 
               
               
                   
               
               
                 SGDGRYFSKE AIQIIIKMAA GNGVKSVWVG QNGLLSTPAV SAVVRERVGA DGCKASGAFI 
                 120 
               
               
                   
               
               
                 LTASHNPGGP NEDFGIKYNM ENGGPAPESI TNKIYENTTQ IKEYLTVDLP EVDITKPGVT 
                 180 
               
               
                   
               
               
                 TFEVEGGTFT VDVFDSASDY VKLMKSIFDF ESIRKLLSSP KFTFCFDALH GVGGAYAKRI 
                 240 
               
               
                   
               
               
                 FVEELGAKES SLLNCVPKED FGGGHPDPNL TYAKELVARM GLSKSNTQNE PPEFGAAADG 
                 300 
               
               
                   
               
               
                 DADRNMVLGK RFFVTPSDSV AIIAANAVEA IPYFSTGLKG VARSMPTSAA LDVVAKHLNL 
                 360 
               
               
                   
               
               
                 KFFEVPTGWK FFGNLMDAGL CSVCGEESFG TGSDHIREKD GIWAVLAWLS IIAIKNKDNI 
                 420 
               
               
                   
               
               
                 GGDKLVTVED IVRKHWATYG RHYYTRYDYE NVDAGKAKDL MASLVNLQSS LPEVNKIVKG 
                 480 
               
               
                   
               
               
                 ICSDVANVVG ADEFEYKDSV DGSISKHQGI RYLFEDGSRL VFRLSGTGSE GATIRLYIEQ 
                 540 
               
               
                   
               
               
                 YENDPSKISR ESSEALAPLV EVALKLSKMQ EFTGRSAPTV IT 
                 582 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 146 
               
               
                 
                   S. rebaudiana 
                 
               
            
           
           
               
               
            
               
                 atggcctctt tcaaggttaa cagagttgaa tcctctccaa tcgaaggtca aaaaccaggt 
                 60 
               
               
                   
               
               
                 acttctggtt tgagaaagaa ggttaaggtt ttcacccaac cacattactt gcacaacttc 
                 120 
               
               
                   
               
               
                 gttcaatcta ctttcaacgc tttgtctgcc gaaaaagtta agggttctac tttggttgtt 
                 180 
               
               
                   
               
               
                 tccggtgatg gtagatatta ctccaaggat gccattcaaa tcatcattaa gatggctgct 
                 240 
               
               
                   
               
               
                 gctaacggtg ttagaagagt ttgggttggt caaaatggtt tgttgtctac tccagctgtt 
                 300 
               
               
                   
               
               
                 tctgctgttg ttagagaaag agttggtgct gatggttcta aatctaacgg tgctttcatt 
                 360 
               
               
                   
               
               
                 ttgactgcct ctcataatcc aggtggtcca aatgaagatt tcggtatcaa gtacaacatg 
                 420 
               
               
                   
               
               
                 gaaaatggtg gtccagctcc agaaggtatt actgataaga tttttgaaaa caccaagacc 
                 480 
               
               
                   
               
               
                 atcaaagaat acttcattgc tgaaggtttg ccagacgttg atatttccgc tattggtatc 
                 540 
               
               
                   
               
               
                 tcttcattct ctggtccaga tggtcaattc gatgttgatg ttttcgattc ctcttccgac 
                 600 
               
               
                   
               
               
                 tacgtcaaat tgatgaagtc catcttcgac ttccaatcca tcaagaagtt gattacctcc 
                 660 
               
               
                   
               
               
                 ccacaatttt ctttctgtta cgatgcttta catggtgttg gtggtgctta tgctaagcca 
                 720 
               
               
                   
               
               
                 atttttgttg atgaattggg tgccaaagaa tcctctttgt tgaactgtgt tcctaaagaa 
                 780 
               
               
                   
               
               
                 gattttggtg gtggtcatcc agatccaaat ttgacttacg ctaaagaatt ggtttccaga 
                 840 
               
               
                   
               
               
                 atgggtttgg gtaagaatcc agattctaat ccaccagaat ttggtgctgc tgcagatggt 
                 900 
               
               
                   
               
               
                 gatgctgata gaaatatgat cttgggtaaa agattcttcg tcaccccatc tgattccgtt 
                 960 
               
               
                   
               
               
                 gctattattg ctgctaatgc cgttcaatca atcccatact tttcatccgg tttgaaaggt 
                 1020 
               
               
                   
               
               
                 gttgctagat ctatgccaac ttctgctgct ttggatgttg ttgctaagtc tttgaacttg 
                 1080 
               
               
                   
               
               
                 aagttcttcg aagttccaac tggttggaag tttttcggta atttgatgga tgctggtttg 
                 1140 
               
               
                   
               
               
                 tgttctgttt gcggtgaaga atcatttggt actggttccg atcatatcag agaaaaggat 
                 1200 
               
               
                   
               
               
                 ggtatttggg ctgttttggc ttggttgtct attttggctc ataagaacaa ggacaacttg 
                 1260 
               
               
                   
               
               
                 aacggtggta acttggttac tgttgaagat atcgttaagc aacattgggc tacttacggt 
                 1320 
               
               
                   
               
               
                 agacattact acactagata cgactacgaa aacgttgatg ctggtgctgc aaaagaattg 
                 1380 
               
               
                   
               
               
                 atggctcatt tggttaagtt gcaatcctcc atctctgatg ttaacacctt cattaagggt 
                 1440 
               
               
                   
               
               
                 atcagatccg atgttgctaa tgttgcatct gctgatgaat tcgaatacaa ggatccagtt 
                 1500 
               
               
                   
               
               
                 gacggttcta tttccaaaca tcaaggtatt agatacttgt ttgaagatgg ttccagattg 
                 1560 
               
               
                   
               
               
                 gttttcagat tgtctggtac aggttctgaa ggtgctacta ttagattgta catcgaacaa 
                 1620 
               
               
                   
               
               
                 tacgaaaagg attcctctaa gaccggtaga gattctcaag aagctttggc tccattagtt 
                 1680 
               
               
                   
               
               
                 gaagttgcct tgaaattgtc caagatgcaa gaattcactg gtagatctgc tccaactgtt 
                 1740 
               
               
                   
               
               
                 attacctga 
                 1749 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 147 
               
               
                 S. rebaudiana 
               
            
           
           
               
               
            
               
                 MASFKVNRVE SSPIEGQKPG TSGLRKKVKV FTQPHYLHNF VQSTFNALSA EKVKGSTLVV 
                 60 
               
               
                   
               
               
                 SGDGRYYSKD AIQIIIKMAA ANGVRRVWVG QNGLLSTPAV SAVVRERVGA DGSKSNGAFI 
                 120 
               
               
                   
               
               
                 LTASHNPGGP NEDFGIKYNM ENGGPAPEGI TDKIFENTKT IKEYFIAEGL PDVDISAIGI 
                 180 
               
               
                   
               
               
                 SSFSGPDGQF DVDVFDSSSD YVKLMKSIFD FQSIKKLITS PQFSFCYDAL HGVGGAYAKP 
                 240 
               
               
                   
               
               
                 IFVDELGAKE SSLLNCVPKE DFGGGHPDPN LTYAKELVSR MGLGKNPDSN PPEFGAAADG 
                 300 
               
               
                   
               
               
                 DADRNMILGK RFFVTPSDSV AIIAANAVQS IPYFSSGLKG VARSMPTSAA LDVVAKSLNL 
                 360 
               
               
                   
               
               
                 KFFEVPTGWK FFGNLMDAGL CSVCGEESFG TGSDHIREKD GIWAVLAWLS ILAHKNKDNL 
                 420 
               
               
                   
               
               
                 NGGNLVTVED IVKQHWATYG RHYYTRYDYE NVDAGAAKEL MAHLVKLQSS ISDVNTFIKG 
                 480 
               
               
                   
               
               
                 IRSDVANVAS ADEFEYKDPV DGSISKHQGI RYLFEDGSRL VFRLSGTGSE GATIRLYIEQ 
                 540 
               
               
                   
               
               
                 YEKDSSKTGR DSQEALAPLV EVALKLSKMQ EFTGRSAPTV IT 
                 582 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 148 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 gcacacacca tagcttcaaa atgtttctac tcctttttta ctcttccaga ttttctcgga 
                 60 
               
               
                   
               
               
                 ctccgcgcat cgccgtacca cttcaaaaca cccaagcaca gcatactaaa tttcccctct 
                 120 
               
               
                   
               
               
                 ttcttcctct agggtgtcgt taattacccg tactaaaggt ttggaaaaga aaaaagagac 
                 180 
               
               
                   
               
               
                 cgcctcgttt ctttttcttc gtcgaaaaag gcaataaaaa tttttatcac gtttcttttt 
                 240 
               
               
                   
               
               
                 cttgaaaatt tttttttttg atttttttct ctttcgatga cctcccattg atatttaagt 
                 300 
               
               
                   
               
               
                 taataaacgg tcttcaattt ctcaagtttc agtttcattt ttcttgttct attacaactt 
                 360 
               
               
                   
               
               
                 tttttacttc ttgctcatta gaaagaaagc atagcaatct aatctaagtt ttaattacaa 
                 420 
               
               
                   
               
               
                 ggatcc 
                 426 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 149 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 ggaagtacct tcaaagaatg gggtcttatc ttgttttgca agtaccactg agcaggataa 
                 60 
               
               
                   
               
               
                 taatagaaat gataatatac tatagtagag ataacgtcga tgacttccca tactgtaatt 
                 120 
               
               
                   
               
               
                 gcttttagtt gtgtattttt agtgtgcaag tttctgtaaa tcgattaatt tttttttctt 
                 180 
               
               
                   
               
               
                 tcctcttttt attaacctta atttttattt tagattcctg acttcaactc aagacgcaca 
                 240 
               
               
                   
               
               
                 gatattataa catctgcata ataggcattt gcaagaatta ctcgtgagta aggaaagagt 
                 300 
               
               
                   
               
               
                 gaggaactat cgcatacctg catttaaaga tgccgatttg ggcgcgaatc ctttattttg 
                 360 
               
               
                   
               
               
                 gcttcaccct catactatta tcagggccag aaaaaggaag tgtttccctc cttcttgaat 
                 420 
               
               
                   
               
               
                 tgatgttacc ctcataaagc acgtggcctc ttatcgagaa agaaattacc gtcgctcgtg 
                 480 
               
               
                   
               
               
                 atttgtttgc aaaaagaaca aaactgaaaa aacccagaca cgctcgactt cctgtcttcc 
                 540 
               
               
                   
               
               
                 tattgattgc agcttccaat ttcgtcacac aacaaggtcc tagcgacggc tcacaggttt 
                 600 
               
               
                   
               
               
                 tgtaacaagc aatcgaaggt tctggaatgg cgggaaaggg tttagtacca catgctatga 
                 660 
               
               
                   
               
               
                 tgcccactgt gatctccaga gcaaagttcg ttcgatcgta ctgttactct ctctctttca 
                 720 
               
               
                   
               
               
                 aacagaattg tccgaatcgt gtgacaacaa cagcctgttc tcacacactc ttttcttcta 
                 780 
               
               
                   
               
               
                 accaaggggg tggtttagtt tagtagaacc tcgtgaaact tacatttaca tatatataaa 
                 840 
               
               
                   
               
               
                 cttgcataaa ttggtcaatg caagaaatac atatttggtc ttttctaatt cgtagttttt 
                 900 
               
               
                   
               
               
                 caagttctta gatgctttct ttttctcttt tttacagatc atcaaggaag taattatcta 
                 960 
               
               
                   
               
               
                 ctttttacaa caaatataaa acaa 
                 984 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 150 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 cattatcaat actgccattt caaagaatac gtaaataatt aatagtagtg attttcctaa 
                 60 
               
               
                   
               
               
                 ctttatttag tcaaaaaatt agccttttaa ttctgctgta acccgtacat gcccaaaata 
                 120 
               
               
                   
               
               
                 gggggcgggt tacacagaat atataacatc gtaggtgtct gggtgaacag tttattcctg 
                 180 
               
               
                   
               
               
                 gcatccacta aatataatgg agcccgcttt ttaagctggc atccagaaaa aaaaagaatc 
                 240 
               
               
                   
               
               
                 ccagcaccaa aatattgttt tcttcaccaa ccatcagttc ataggtccat tctcttagcg 
                 300 
               
               
                   
               
               
                 caactacaga gaacaggggc acaaacaggc aaaaaacggg cacaacctca atggagtgat 
                 360 
               
               
                   
               
               
                 gcaacctgcc tggagtaaat gatgacacaa ggcaattgac ccacgcatgt atctatctca 
                 420 
               
               
                   
               
               
                 ttttcttaca ccttctatta ccttctgctc tctctgattt ggaaaaagct gaaaaaaaag 
                 480 
               
               
                   
               
               
                 gttgaaacca gttccctgaa attattcccc tacttgacta ataagtatat aaagacggta 
                 540 
               
               
                   
               
               
                 ggtattgatt gtaattctgt aaatctattt cttaaacttc ttaaattcta cttttatagt 
                 600 
               
               
                   
               
               
                 tagtcttttt tttagtttta aaacaccaag aacttagttt cgaataaaca cacataaaca 
                 660 
               
               
                   
               
               
                 aacaaa 
                 666 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 151 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 gatctgggcc gtatacttac atatagtaga tgtcaagcgt aggcgcttcc cctgccggct 
                 60 
               
               
                   
               
               
                 gtgagggcgc cataaccaag gtatctatag accgccaatc agcaaactac ctccgtacat 
                 120 
               
               
                   
               
               
                 tcatgttgca cccacacatt tatacaccca gaccgcgaca aattacccat aaggttgttt 
                 180 
               
               
                   
               
               
                 gtgacggcgt cgtacaagag aacgtgggaa ctttttaggc tcaccaaaaa agaaagaaaa 
                 240 
               
               
                   
               
               
                 aatacgagtt gctgacagaa gcctcaagaa aaaaaaaatt cttcttcgac tatgctggag 
                 300 
               
               
                   
               
               
                 gcagagatga tcgagccggt agttaactat atatagctaa attggttcca tcaccttctt 
                 360 
               
               
                   
               
               
                 ttctggtgtc gctccttcta gtgctatttc tggcttttcc tatttttttt tttccatttt 
                 420 
               
               
                   
               
               
                 tctttctctc tttctaatat ataaattctc ttgcattttc tatttttctc tctatctatt 
                 480 
               
               
                   
               
               
                 ctacttgttt attcccttca aggttttttt ttaaggagta cttgttttta gaatatacgg 
                 540 
               
               
                   
               
               
                 tcaacgaact ataattaact aaaca 
                 565 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 152 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 agttataata atcctacgtt agtgtgagcg ggatttaaac tgtgaggacc ttaatacatt 
                 60 
               
               
                   
               
               
                 cagacacttc tgcggtatca ccctacttat tcccttcgag attatatcta ggaacccatc 
                 120 
               
               
                   
               
               
                 aggttggtgg aagattaccc gttctaagac ttttcagctt cctctattga tgttacacct 
                 180 
               
               
                   
               
               
                 ggacacccct tttctggcat ccagttttta atcttcagtg gcatgtgaga ttctccgaaa 
                 240 
               
               
                   
               
               
                 ttaattaaag caatcacaca attctctcgg ataccacctc ggttgaaact gacaggtggt 
                 300 
               
               
                   
               
               
                 ttgttacgca tgctaatgca aaggagccta tatacctttg gctcggctgc tgtaacaggg 
                 360 
               
               
                   
               
               
                 aatataaagg gcagcataat ttaggagttt agtgaacttg caacatttac tattttccct 
                 420 
               
               
                   
               
               
                 tcttacgtaa atatttttct ttttaattct aaatcaatct ttttcaattt tttgtttgta 
                 480 
               
               
                   
               
               
                 ttcttttctt gcttaaatct ataactacaa aaaacacata cataaactaa aa 
                 532 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 153 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 gatctatgcg actgggtgag catatgttcc gctgatgtga tgtgcaagat aaacaagcaa 
                 60 
               
               
                   
               
               
                 ggcagaaact aacttcttct tcatgtaata aacacacccc gcgtttattt acctatctct 
                 120 
               
               
                   
               
               
                 aaacttcaac accttatatc ataactaata tttcttgaga taagcacact gcacccatac 
                 180 
               
               
                   
               
               
                 cttccttaaa aacgtagctt ccagtttttg gtggttccgg cttccttccc gattccgccc 
                 240 
               
               
                   
               
               
                 gctaaacgca tatttttgtt gcctggtggc atttgcaaaa tgcataacct atgcatttaa 
                 300 
               
               
                   
               
               
                 aagattatgt atgctcttct gacttttcgt gtgatgaggc tcgtggaaaa aatgaataat 
                 360 
               
               
                   
               
               
                 ttatgaattt gagaacaatt ttgtgttgtt acggtatttt actatggaat aatcaatcaa 
                 420 
               
               
                   
               
               
                 ttgaggattt tatgcaaata tcgtttgaat atttttccga ccctttgagt acttttcttc 
                 480 
               
               
                   
               
               
                 ataattgcat aatattgtcc gctgcccctt tttctgttag acggtgtctt gatctacttg 
                 540 
               
               
                   
               
               
                 ctatcgttca acaccacctt attttctaac tatttttttt ttagctcatt tgaatcagct 
                 600 
               
               
                   
               
               
                 tatggtgatg gcacattttt gcataaacct agctgtcctc gttgaacata ggaaaaaaaa 
                 660 
               
               
                   
               
               
                 atatataaac aaggctcttt cactctcctt gcaatcagat ttgggtttgt tccctttatt 
                 720 
               
               
                   
               
               
                 ttcatatttc ttgtcatatt cctttctcaa ttattatttt ctactcataa cctcacgcaa 
                 780 
               
               
                   
               
               
                 aataacacag tcaaatctat caaaa 
                 805 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 154 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 atccgctcta accgaaaagg aaggagttag acaacctgaa gtctaggtcc ctatttattt 
                 60 
               
               
                   
               
               
                 tttttaatag ttatgttagt attaagaacg ttatttatat ttcaaatttt tctttttttt 
                 120 
               
               
                   
               
               
                 ctgtacaaac gcgtgtacgc atgtaacatt atactgaaaa ccttgcttga gaaggttttg 
                 180 
               
               
                   
               
               
                 ggacgctcga ag 
                 192 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 155 
               
               
                 Artificial Sequence 
               
            
           
           
               
               
            
               
                 gtagatacgt tgttgacact tctaaataag cgaatttctt atgatttatg atttttatta 
                 60 
               
               
                   
               
               
                 ttaaataagt tataaaaaaa ataagtgtat acaaatttta aagtgactct taggttttaa 
                 120 
               
               
                   
               
               
                 aacgaaaatt cttattcttg agtaactctt tcctgtaggt caggttgctt tctcaggtat 
                 180 
               
               
                   
               
               
                 agcatgaggt cgctc 
                 195 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 156 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 atgaatagat cattactgct acgtttgtcg gataccggtg aacccattac aagctgctct 
                 60 
               
               
                   
               
               
                 tacggaaaag gtgtcttgac gctaccacca attccgctcc ctaaggacgc cccaaaggac 
                 120 
               
               
                   
               
               
                 caaccgctct atacggtcaa gctactggta tctgcaggtt cccctgtcgc tagggatggg 
                 180 
               
               
                   
               
               
                 ctagtttgga ctaattgccc accagatcac aacacgccct tcaagaggga caaattttac 
                 240 
               
               
                   
               
               
                 aaaaaaatca ttcattccag ctttcacgag gatgactgca ttgacctgaa tgtctacgct 
                 300 
               
               
                   
               
               
                 ccaggctcgt actgctttta tctatctttc aggaacgata acgaaaaact tgagacaaca 
                 360 
               
               
                   
               
               
                 aggaaatact actttgttgc cttgcccatg ctttatataa acgatcagtt cctacctttg 
                 420 
               
               
                   
               
               
                 aattccatcg ctttacaaag tgttgtatcg aaatggctgg gctctgactg ggagcccatc 
                 480 
               
               
                   
               
               
                 ctatcgaaaa ttgccgctaa aaactacaat atggtacatt tcacccctct acaggaaaga 
                 540 
               
               
                   
               
               
                 ggcgagtcta actcgcctta ctctatatac gaccaattgc agttcgacca ggaacacttt 
                 600 
               
               
                   
               
               
                 aagtctcctg aagacgtgaa aaatttagtt gagcatatac atcgcgattt aaacatgctt 
                 660 
               
               
                   
               
               
                 tcattaacag atattgtttt taaccacaca gctaataatt ctccttggtt agttgagcac 
                 720 
               
               
                   
               
               
                 ccggaggctg ggtataacca catcactgcg ccacatctaa tcagcgccat agagctcgac 
                 780 
               
               
                   
               
               
                 caagaattgc tcaattttag taggaatttg aaatcctggg gctatcctac cgaactgaaa 
                 840 
               
               
                   
               
               
                 aatatagaag atctcttcaa gatcatggac ggtattaaag tgcatgtttt agggtcgttg 
                 900 
               
               
                   
               
               
                 aaactgtggg aatattatgc ggtaaacgtg caaacagctc ttcgggatat caaagcccat 
                 960 
               
               
                   
               
               
                 tggaatgacg aatctaacga aagttacagt tttcccgaga atattaaaga catctcgtcc 
                 1020 
               
               
                   
               
               
                 gatttcgtaa aactagcttc ctttgtgaag gacaacgtca ctgagcctaa cttcggcact 
                 1080 
               
               
                   
               
               
                 cttggtgaaa gaaactcaaa caggattaac gtgccaaaat ttattcaact actgaagctc 
                 1140 
               
               
                   
               
               
                 attaacgatg gtggtagtga tgacagtgaa tcttcgttgg ccacggctca aaacatcttg 
                 1200 
               
               
                   
               
               
                 aacgaggtca acttaccctt atatagagaa tacgacgatg atgtcagtga gatactcgag 
                 1260 
               
               
                   
               
               
                 caactgttca atcgtatcaa atatttgaga ttagatgacg gtgggcccaa gcaaggtcca 
                 1320 
               
               
                   
               
               
                 gtgaccgttg acgtgccctt aacagagcct tattttacga ggttcaaagg aaaagatggt 
                 1380 
               
               
                   
               
               
                 actgattatg ccctcgccaa caatggctgg atatggaatg gtaacccact agtggatttt 
                 1440 
               
               
                   
               
               
                 gcatcgcaga attcaagagc ttatttacgt agagaagtta tcgtgtgggg ggactgtgtc 
                 1500 
               
               
                   
               
               
                 aagttaagat acggtaaaag ccctgaagac tctccgtatc tgtgggaaag aatgtccaag 
                 1560 
               
               
                   
               
               
                 tatatagaaa tgaacgccaa gatatttgac gggttcagaa ttgacaactg ccattctact 
                 1620 
               
               
                   
               
               
                 ccaatacatg ttggcgaata tttcctagat ttggcaagaa aatacaaccc gaacctatat 
                 1680 
               
               
                   
               
               
                 gtcgttgcag agctgttttc tggttccgaa acactagatt gtctgtttgt tgaacggttg 
                 1740 
               
               
                   
               
               
                 ggtatctcct ctttaatcag agaggcaatg caagcctggt ccgaagaaga gttgtctaga 
                 1800 
               
               
                   
               
               
                 ttagtccata agcatggcgg gaggcccatt ggctcctata agtttgttcc tatggatgac 
                 1860 
               
               
                   
               
               
                 ttctcatatc ctgcggatat taatttaaac gaggagcatt gtttcaacga ctccaacgat 
                 1920 
               
               
                   
               
               
                 aactccataa gatgtgtatc agagatcatg attccaaaga ttttaaccgc cactccgcca 
                 1980 
               
               
                   
               
               
                 cacgctttat tcatggactg tacccatgat aatgaaactc cctttgaaaa aagaacagtg 
                 2040 
               
               
                   
               
               
                 gaggatactt tgcccaatgc tgcattggtg gctctttgct cgtccgccat tggatctgtt 
                 2100 
               
               
                   
               
               
                 tatggctacg acgaaatttt tccacattta ctgaatttgg tcactgaaaa aagacattat 
                 2160 
               
               
                   
               
               
                 gacatttcta cgcctactgg tagcccctcg ataggaataa ccaaagtcaa ggccactttg 
                 2220 
               
               
                   
               
               
                 aattcgatta gaacgagtat aggagaaaag gcgtatgaca ttgaagactc agaaatgcat 
                 2280 
               
               
                   
               
               
                 gtgcatcacc agggccagta cattactttt catcgtatgg atgttaaatc cggaaaaggt 
                 2340 
               
               
                   
               
               
                 tggtacttga tagcaaggat gaaattttct gacaatgatg accctaacga gactttacca 
                 2400 
               
               
                   
               
               
                 ccagtggtgt taaaccaatc cacctgttct ctcaggtttt cgtatgcttt ggaaagagtt 
                 2460 
               
               
                   
               
               
                 ggcgatgaaa ttcccaacga cgataaattc attaaaggta ttcccacgaa attaaaggag 
                 2520 
               
               
                   
               
               
                 cttgaagggt ttgacatttc ttatgatgat tctaagaaga tttcaacgat aaaactgccc 
                 2580 
               
               
                   
               
               
                 aatgaattcc ctcaaggatc tattgccatt tttgagaccc aacagaatgg tgtggacgaa 
                 2640 
               
               
                   
               
               
                 tccttagatc attttataag gtcaggtgct ttaaaggcca cttcaagttt gactctagag 
                 2700 
               
               
                   
               
               
                 tcaataaatt ccgtcttgta tcgtagtgag ccggaagaat acgatgttag cgccggcgaa 
                 2760 
               
               
                   
               
               
                 ggtggtgctt atattattcc taattttgga aagcctgtgt attgtggtct gcaaggttgg 
                 2820 
               
               
                   
               
               
                 gtttccgtat taagaaaaat tgtgttttac aatgatttag cacatcccct cagtgcaaat 
                 2880 
               
               
                   
               
               
                 ttaagaaatg gacattgggc tttagactac actatcagta gacttaatta ctatagcgat 
                 2940 
               
               
                   
               
               
                 gaagcaggaa tcaatgaagt gcagaactgg ctgcgttcaa ggtttgatag agtgaaaaag 
                 3000 
               
               
                   
               
               
                 ttaccgagct acttagtgcc cagttatttc gccttaatta tcggcatcct ctatggttgt 
                 3060 
               
               
                   
               
               
                 tgtcgcttaa aagcaataca gctaatgtcc cgtaatattg gtaaatctac attgtttgta 
                 3120 
               
               
                   
               
               
                 caaagcttat ctatgacatc aatccagatg gtttccagaa tgaagtcaac ctctatttta 
                 3180 
               
               
                   
               
               
                 ccaggcgaaa atgttccatc tatggctgca gggttgccac actttagcgt aaactacatg 
                 3240 
               
               
                   
               
               
                 agatgttggg ggagagatgt attcatatcg ctaagaggta tgctattaac aacaggtaga 
                 3300 
               
               
                   
               
               
                 tttgatgaag ctaaagctca tatactagcc tttgcaaaga ctttgaagca tggtttaatt 
                 3360 
               
               
                   
               
               
                 ccaaacttgc tggatgccgg tagaaacccg agatataatg ctcgtgatgc tgcctggttc 
                 3420 
               
               
                   
               
               
                 ttcttgcaag ctgtacagga ttatgtttat attgttcctg atggcgaaaa aatattacaa 
                 3480 
               
               
                   
               
               
                 gagcaagtaa caaggagatt cccactggat gatacttaca ttcctgtaga tgatccaagg 
                 3540 
               
               
                   
               
               
                 gcatttagtt actctagtac cttggaggag atcatttatg aaattttgag taggcatgcc 
                 3600 
               
               
                   
               
               
                 aagggaatta aattcagaga ggctaatgca ggtccaaatt tagatcgtgt tatgactgat 
                 3660 
               
               
                   
               
               
                 aaagggttta atgttgaaat tcatgtcgat tggtcgactg gcttaattca tggtggatct 
                 3720 
               
               
                   
               
               
                 cagtataact gtggtacttg gatggataag atgggtgaaa gtgaaaaagc agggtctgtt 
                 3780 
               
               
                   
               
               
                 ggtattcctg gaacacccag agatggagcc gcaatagaaa tcaatgggct tttaaaaagt 
                 3840 
               
               
                   
               
               
                 gctttaaggt ttgttattga actaaaaaac aagggattgt ttaagttttc cgatgtggag 
                 3900 
               
               
                   
               
               
                 acgcaggacg gcgggaggat cgatttcact gaatggaatc aattacttca agacaatttc 
                 3960 
               
               
                   
               
               
                 gaaaaaagat attatgttcc ggaggatcca tcacaggatg cagattatga cgtgagcgct 
                 4020 
               
               
                   
               
               
                 aaattgggtg ttaatagacg ggggatatac agagatttgt acaaatcagg aaagccttat 
                 4080 
               
               
                   
               
               
                 gaagattatc agttaagacc aaattttgct attgccatga ctgtggcacc agagttattt 
                 4140 
               
               
                   
               
               
                 gtgcctgagc atgccataaa agcaatcacc attgcagatg aagtcttaag aggtccagta 
                 4200 
               
               
                   
               
               
                 ggtatgcgta ctttagaccc aagcgattac aattaccgtc cgtactacaa caacggagaa 
                 4260 
               
               
                   
               
               
                 gattcggatg attttgccac ctcaaagggt agaaactatc accaaggccc tgagtgggtc 
                 4320 
               
               
                   
               
               
                 tggctttacg gctacttttt aagagcgttc catcatttcc actttaaaac cagtccacgt 
                 4380 
               
               
                   
               
               
                 tgtcagaatg ctgccaaaga gaaaccatcc tcttatttgt atcaacaatt atactacaga 
                 4440 
               
               
                   
               
               
                 ttaaaaggcc atagaaaatg gatttttgaa agtgtgtggg caggattgac agagctaacc 
                 4500 
               
               
                   
               
               
                 aataaagatg gtgaagtatg caatgactca agccccacgc aagcctggag ttctgcttgt 
                 4560 
               
               
                   
               
               
                 ttgttagatc tattttatga tttatgggat gcctacgaag atgattcctg a 
                 4611 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 157 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 MNRSLLLRLS DTGEPITSCS YGKGVLTLPP IPLPKDAPKD QPLYTVKLLV SAGSPVARDG 
                 60 
               
               
                   
               
               
                 LVWTNCPPDH NTPFKRDKFY KKIIHSSFHE DDCIDLNVYA PGSYCFYLSF RNDNEKLETT 
                 120 
               
               
                   
               
               
                 RKYYFVALPM LYINDQFLPL NSIALQSVVS KWLGSDWEPI LSKIAAKNYN MVHFTPLQER 
                 180 
               
               
                   
               
               
                 GESNSPYSIY DQLQFDQEHF KSPEDVKNLV EHIHRDLNML SLTDIVFNHT ANNSPWLVEH 
                 240 
               
               
                   
               
               
                 PEAGYNHITA PHLISAIELD QELLNFSRNL KSWGYPTELK NIEDLFKIMD GIKVHVLGSL 
                 300 
               
               
                   
               
               
                 KLWEYYAVNV QTALRDIKAH WNDESNESYS FPENIKDISS DFVKLASFVK DNVTEPNFGT 
                 360 
               
               
                   
               
               
                 LGERNSNRIN VPKFIQLLKL INDGGSDDSE SSLATAQNIL NEVNLPLYRE YDDDVSEILE 
                 420 
               
               
                   
               
               
                 QLFNRIKYLR LDDGGPKQGP VTVDVPLTEP YFTRFKGKDG TDYALANNGW IWNGNPLVDF 
                 480 
               
               
                   
               
               
                 ASQNSRAYLR REVIVWGDCV KLRYGKSPED SPYLWERMSK YIEMNAKIFD GFRIDNCHST 
                 540 
               
               
                   
               
               
                 PIHVGEYFLD LARKYNPNLY VVAELFSGSE TLDCLFVERL GISSLIREAM QAWSEEELSR 
                 600 
               
               
                   
               
               
                 LVHKHGGRPI GSYKFVPMDD FSYPADINLN EEHCFNDSND NSIRCVSEIM IPKILTATPP 
                 660 
               
               
                   
               
               
                 HALFMDCTHD NETPFEKRTV EDTLPNAALV ALCSSAIGSV YGYDEIFPHL LNLVTEKRHY 
                 720 
               
               
                   
               
               
                 DISTPTGSPS IGITKVKATL NSIRTSIGEK AYDIEDSEMH VHHQGQYITF HRMDVKSGKG 
                 780 
               
               
                   
               
               
                 WYLIARMKFS DNDDPNETLP PVVLNQSTCS LRFSYALERV GDEIPNDDKF IKGIPTKLKE 
                 840 
               
               
                   
               
               
                 LEGFDISYDD SKKISTIKLP NEFPQGSIAI FETQQNGVDE SLDHFIRSGA LKATSSLTLE 
                 900 
               
               
                   
               
               
                 SINSVLYRSE PEEYDVSAGE GGAYIIPNFG KPVYCGLQGW VSVLRKIVFY NDLAHPLSAN 
                 960 
               
               
                   
               
               
                 LRNGHWALDY TISRLNYYSD EAGINEVQNW LRSRFDRVKK LPSYLVPSYF ALIIGILYGC 
                 1020 
               
               
                   
               
               
                 CRLKAIQLMS RNIGKSTLFV QSLSMTSIQM VSRMKSTSIL PGENVPSMAA GLPHFSVNYM 
                 1080 
               
               
                   
               
               
                 RCWGRDVFIS LRGMLLTTGR FDEAKAHILA FAKTLKHGLI PNLLDAGRNP RYNARDAAWF 
                 1140 
               
               
                   
               
               
                 FLQAVQDYVY IVPDGEKILQ EQVTRRFPLD DTYIPVDDPR AFSYSSTLEE IIYEILSRHA 
                 1200 
               
               
                   
               
               
                 KGIKFREANA GPNLDRVMTD KGFNVEIHVD WSTGLIHGGS QYNCGTWMDK MGESEKAGSV 
                 1260 
               
               
                   
               
               
                 GIPGTPRDGA AIEINGLLKS ALRFVIELKN KGLFKFSDVE TQDGGRIDFT EWNQLLQDNF 
                 1320 
               
               
                   
               
               
                 EKRYYVPEDP SQDADYDVSA KLGVNRRGIY RDLYKSGKPY EDYQLRPNFA IAMTVAPELF 
                 1380 
               
               
                   
               
               
                 VPEHAIKAIT IADEVLRGPV GMRTLDPSDY NYRPYYNNGE DSDDFATSKG RNYHQGPEWV 
                 1440 
               
               
                   
               
               
                 WLYGYFLRAF HHFHFKTSPR CQNAAKEKPS SYLYQQLYYR LKGHRKWIFE SVWAGLTELT 
                 1500 
               
               
                   
               
               
                 NKDGEVCNDS SPTQAWSSAC LLDLFYDLWD AYEDDS 
                 1536 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 158 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 atgccgccag ctagtactag tactaccaat gatatgataa ccgaagaacc tacttctcca 
                 60 
               
               
                   
               
               
                 caccaaatcc caaggcttac aaggagactt acggggtttc ttccccaaga aatcaagtca 
                 120 
               
               
                   
               
               
                 attgacacga tgattccttt aaagtcaaga gcgttatgga ataagcatca agtcaaaaaa 
                 180 
               
               
                   
               
               
                 tttaacaagg cagaagattt tcaagataga ttcattgacc atgtggaaac tacattagca 
                 240 
               
               
                   
               
               
                 cgttccctat ataattgtga tgacatggct gcttatgaag ctgcttcgat gagtattcgt 
                 300 
               
               
                   
               
               
                 gacaatttgg tcattgactg gaacaaaact cagcagaaat tcaccacaag agacccaaag 
                 360 
               
               
                   
               
               
                 agagtttact atttgtcttt ggagtttttg atgggtaggg ctttggataa tgccctgatt 
                 420 
               
               
                   
               
               
                 aatatgaaga ttgaagatcc ggaagaccct gctgcctcaa agggaaaacc aagagaaatg 
                 480 
               
               
                   
               
               
                 attaaagggg ctttggatga tttaggtttc aagttagagg atgtcttgga ccaagaaccg 
                 540 
               
               
                   
               
               
                 gacgcaggtt taggtaatgg tggtctaggt cgtcttgcag cttgcttcgt cgactcaatg 
                 600 
               
               
                   
               
               
                 gcaacggaag gcatccctgc ctggggttat ggtctacgtt atgagtatgg tatctttgct 
                 660 
               
               
                   
               
               
                 caaaagatta ttgacggtta ccaggtggaa actccagatt actggttaaa ttctggtaat 
                 720 
               
               
                   
               
               
                 ccatgggaaa ttgaacgtaa cgaagtgcaa attcctgtca ccttttatgg ttatgttgat 
                 780 
               
               
                   
               
               
                 agaccagaag gcggtaaaac tacactgagt gcgtcacaat ggatcggtgg ggaaagagtt 
                 840 
               
               
                   
               
               
                 cttgctgtcg cgtatgattt cccagttccg ggtttcaaga cttccaatgt aaataactta 
                 900 
               
               
                   
               
               
                 agactatggc aagcaaggcc aacaacagaa tttgattttg caaaattcaa taatggtgac 
                 960 
               
               
                   
               
               
                 tataaaaact ctgtggctca gcaacaacgc gcagagtcta taaccgctgt gttgtatcca 
                 1020 
               
               
                   
               
               
                 aacgataact ttgctcaagg taaggagttg aggttgaaac agcagtactt ctggtgtgct 
                 1080 
               
               
                   
               
               
                 gcatccttac acgacatctt aagaagattc aaaaaatcca agaggccatg gactgaattt 
                 1140 
               
               
                   
               
               
                 cctgaccaag tggctattca gttgaatgat actcatccaa ctttagccat cgttgaatta 
                 1200 
               
               
                   
               
               
                 cagagagttt tggtcgatct agaaaaacta gattggcacg aggcttggga catcgtgacc 
                 1260 
               
               
                   
               
               
                 aagacttttg cttatactaa ccacactgtt atgcaagagg ccctggaaaa atggcccgtc 
                 1320 
               
               
                   
               
               
                 ggcctctttg gccatttgct acccagacat ttggaaatta tatatgatat caactggttc 
                 1380 
               
               
                   
               
               
                 ttcttgcaag atgtggccaa aaaattcccc aaggatgttg atcttttgtc tcgtatatcc 
                 1440 
               
               
                   
               
               
                 atcatcgaag aaaactctcc agaaagacag atcagaatgg cctttttggc tattgttggt 
                 1500 
               
               
                   
               
               
                 tcacacaagg ttaatggtgt tgctgaattg cactctgaat taatcaaaac gaccatattt 
                 1560 
               
               
                   
               
               
                 aaagattttg tcaagttcta tggtccatca aagtttgtca atgtcactaa cggtatcaca 
                 1620 
               
               
                   
               
               
                 ccaaggagat ggttgaagca agctaaccct tcattggcta aactgatcag tgaaaccctt 
                 1680 
               
               
                   
               
               
                 aacgatccaa cagaggagta tttgttggac atggccaaac tgacccagtt gggaaaatat 
                 1740 
               
               
                   
               
               
                 gttgaagata aggagttttt gaaaaaatgg aaccaagtca agcttaataa taagatcaga 
                 1800 
               
               
                   
               
               
                 ttagtagatt taatcaaaaa ggaaaatgat ggagtagaca tcattaacag agagtatttg 
                 1860 
               
               
                   
               
               
                 gacgacacct tgtttgatat gcaagttaaa cgtattcatg aatataagcg tcaacagcta 
                 1920 
               
               
                   
               
               
                 aacgtctttg gtattatata ccgttacctg gcaatgaaga atatgctgaa gaacggtgct 
                 1980 
               
               
                   
               
               
                 tcgatcgaag aagttgccaa gaaatatcca cgcaaggttt caatctttgg tggtaagagt 
                 2040 
               
               
                   
               
               
                 gctcctggtt actacatggc taagctgatc ataaaattga tcaactgtgt tgctgacatt 
                 2100 
               
               
                   
               
               
                 gttaataacg acgagtcaat tgagcatttg ttgaaggttg tctttgttgc tgattataat 
                 2160 
               
               
                   
               
               
                 gtttctaagg ctgaaatcat tattccagca agtgacttga gtgagcatat ttctactgct 
                 2220 
               
               
                   
               
               
                 ggtactgaag cgtctggtac ttctaatatg aagtttgtta tgaacggtgg tttgattatt 
                 2280 
               
               
                   
               
               
                 ggtactgttg atggtgccaa tgtggaaatc acaagggaaa ttggtgaaga taatgtcttc 
                 2340 
               
               
                   
               
               
                 ttgtttggta acctaagtga aaatgtcgaa gaattgagat acaaccatca ataccatcca 
                 2400 
               
               
                   
               
               
                 caagatttac catctagttt ggattctgtt ttatcctaca ttgaaagtgg acaattttct 
                 2460 
               
               
                   
               
               
                 ccagaaaatc caaatgaatt caaaccttta gtcgacagta ttaagtacca cggcgattat 
                 2520 
               
               
                   
               
               
                 tacctggtca gtgatgactt tgaatcctat ctggccaccc atgaattagt ggaccaggag 
                 2580 
               
               
                   
               
               
                 ttccacaatc aaaggtcaga atggttaaaa aagagtgtcc tgagcgttgc aaacgtcggc 
                 2640 
               
               
                   
               
               
                 ttctttagca gtgatcgttg tatcgaggaa tactccgata ccatttggaa cgttgaacca 
                 2700 
               
               
                   
               
               
                 gtgacttag 
                 2709 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 159 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 MPPASTSTTN DMITEEPTSP HQIPRLTRRL TGFLPQEIKS IDTMIPLKSR ALWNKHQVKK 
                 60 
               
               
                   
               
               
                 FNKAEDFQDR FIDHVETTLA RSLYNCDDMA AYEAASMSIR DNLVIDWNKT QQKFTTRDPK 
                 120 
               
               
                   
               
               
                 RVYYLSLEFL MGRALDNALI NMKIEDPEDP AASKGKPREM IKGALDDLGF KLEDVLDQEP 
                 180 
               
               
                   
               
               
                 DAGLGNGGLG RLAACFVDSM ATEGIPAWGY GLRYEYGIFA QKIIDGYQVE TPDYWLNSGN 
                 240 
               
               
                   
               
               
                 PWEIERNEVQ IPVTFYGYVD RPEGGKTTLS ASQWIGGERV LAVAYDFPVP GFKTSNVNNL 
                 300 
               
               
                   
               
               
                 RLWQARPTTE FDFAKFNNGD YKNSVAQQQR AESITAVLYP NDNFAQGKEL RLKQQYFWCA 
                 360 
               
               
                   
               
               
                 ASLHDILRRF KKSKRPWTEF PDQVAIQLND THPTLAIVEL QRVLVDLEKL DWHEAWDIVT 
                 420 
               
               
                   
               
               
                 KTFAYTNHTV MQEALEKWPV GLFGHLLPRH LEIIYDINWF FLQDVAKKFP KDVDLLSRIS 
                 480 
               
               
                   
               
               
                 IIEENSPERQ IRMAFLAIVG SHKVNGVAEL HSELIKTTIF KDFVKFYGPS KFVNVTNGIT 
                 540 
               
               
                   
               
               
                 PRRWLKQANP SLAKLISETL NDPTEEYLLD MAKLTQLGKY VEDKEFLKKW NQVKLNNKIR 
                 600 
               
               
                   
               
               
                 LVDLIKKEND GVDIINREYL DDTLFDMQVK RIHEYKRQQL NVFGIIYRYL AMKNMLKNGA 
                 660 
               
               
                   
               
               
                 SIEEVAKKYP RKVSIFGGKS APGYYMAKLI IKLINCVADI VNNDESIEHL LKVVFVADYN 
                 720 
               
               
                   
               
               
                 VSKAEIIIPA SDLSEHISTA GTEASGTSNM KFVMNGGLII GTVDGANVEI TREIGEDNVF 
                 780 
               
               
                   
               
               
                 LFGNLSENVE ELRYNHQYHP QDLPSSLDSV LSYIESGQFS PENPNEFKPL VDSIKYHGDY 
                 840 
               
               
                   
               
               
                 YLVSDDFESY LATHELVDQE FHNQRSEWLK KSVLSVANVG FFSSDRCIEE YSDTIWNVEP 
                 900 
               
               
                   
               
               
                 VT 
                 902 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 160 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 MSKQFSHTTN DRRSSIIYST SVGKAGLFTP ADYIPQESEE NLIEGEEQEG SEEEPSYTGN 
                 60 
               
               
                   
               
               
                 DDETEREGEY HSLLDANNSR TLQQEAWQQG YDSHDRKRLL DEERDLLIDN KLLSQHGNGG 
                 120 
               
               
                   
               
               
                 GDIESHGHGQ AIGPDEEERP AEIANTWESA IESGQKISTT FKRETQVITM NALPLIFTFI 
                 180 
               
               
                   
               
               
                 LQNSLSLASI FSVAHLGTKE LGGVTLGSMT ANITGLAAIQ GLCTCLGTLC AQAYGAKNYH 
                 240 
               
               
                   
               
               
                 LVGVLVQRCA VITILAFLPM MYVWFVWSEK ILALMIPERE LCALAANYLR VTAFGVPGFI 
                 300 
               
               
                   
               
               
                 LFECGKRFLQ CQGIFHASTI VLFVCAPLNA LMNYLLVWND KIGIGYLGAP LSVVINYWLM 
                 360 
               
               
                   
               
               
                 TLGLLIYAMT TKHKERPLKC WNGIIPKEQA FKNWRKMINL AIPGVVMVEA EFLGFEVLTI 
                 420 
               
               
                   
               
               
                 FASHLGTDAL GAQSIVATIA SLAYQVPFSI SVSTSTRVAN FIGASLYDSC MITCRVSLLL 
                 480 
               
               
                   
               
               
                 SFVCSSMNMF VICRYKEQIA SLFSTESAVV KMVVDTLPLL AFMQLFDAFN ASTAGCLRGQ 
                 540 
               
               
                   
               
               
                 GRQKIGGYIN LVAFYCLGVP MAYVLAFLYH LGVGGLWLGI TSALVMMSVC QGYAVFHGDR 
                 600 
               
               
                   
               
               
                 RRILGAARKR NAETHTS 
                 617 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 161 
               
               
                 
                   S. cerevisiae 
                 
               
            
           
           
               
               
            
               
                 atgtctaaac aatttagtca taccaccaac gacagaagat catcgattat ctactccacc 
                 60 
               
               
                   
               
               
                 agtgtcggaa aggcagggct tttcacgcct gcagactaca tcccacagga gtcagaagaa 
                 120 
               
               
                   
               
               
                 aacttaattg agggcgaaga gcaagagggt agcgaagaag aaccttccta taccggcaat 
                 180 
               
               
                   
               
               
                 gacgatgaga cggagaggga aggtgaatac cattcgttat tagatgccaa caattcgcgg 
                 240 
               
               
                   
               
               
                 acattgcaac aagaagcgtg gcaacaaggt tatgactctc acgaccgtaa gcgtttgctt 
                 300 
               
               
                   
               
               
                 gacgaagaac gggacctgct aatagacaac a