Patent Publication Number: US-7909765-B2

Title: Method and apparatus for determining true intraocular pressure

Description:
CROSS REFERENCE TO RELATED APPLICATIONS 
     The present application claims benefit under 35 USC §120 as a divisional application of copending U.S. application Ser. No. 11/222,166 filed Sep. 8, 2005, now U.S. Pat. No. 7,481,767. 
    
    
     FIELD OF THE INVENTION 
     The invention relates generally to the field of ophthalmology, and more specifically to a method and apparatus for providing an intraocular pressure (IOP) measurement that is substantially independent of corneal effects, whereby the measured IOP value approaches true IOP. 
     BACKGROUND OF THE INVENTION 
     Tonometers for measuring IOP were originally developed as “contact” type instruments, meaning that a portion of the instrument is brought into contact with the cornea during the measurement procedure. A well-known instrument of this type is the Goldmann applanation tonometer (GAT) originally developed during the 1950s. The GAT measures the force required to flatten (“applanate”) a known area of the cornea, and is used today as a standard against which other types of tonometers are compared to assess measurement accuracy. 
     Patient discomfort caused by contact tonometers such as the GAT led to the development of “non-contact” tonometers (NCTs) which operate by directing an air pulse at the patient&#39;s cornea to cause applanation. As the cornea is deformed by the fluid pulse, an opto-electronic system monitors the cornea by detecting corneally reflected light from a beam obliquely incident upon the cornea, and a peak detector signal occurs at the moment of applanation when the reflecting surface of the cornea is flat. 
     In state of the art NCTs, a pressure transducer measures the pump plenum pressure as the pulse is generated to provide a plenum pressure signal, whereby the plenum pressure at the moment applanation is achieved (indicated by a sharp peak in the applanation signal) can be determined. The plenum pressure at applanation is then converted to an IOP value in units of millimeters mercury (mmHg) using a linear regression equation stored during instrument clinical calibration relative to GAT as a reference. A primary index of an NCT&#39;s reliability is the standard deviation of differences S d  of matched pairs of NCT and GAT clinical readings. 
     Current NCTs provide reasonably reliable IOP measurements, however recent studies indicate that corneal effects can have a significant impact on conventional NCT readings. This is not surprising, given that the cornea must be acted upon during the pressure measurement process and the air pulse must expend some of its energy “bending” the corneal tissue itself. Consequently, IOP readings are falsely inflated to a degree that varies from patient to patient depending upon the physical properties and characteristics of the patient&#39;s cornea at the time of measurement, such as thickness, hydration, and intrinsic tissue properties. True IOP is independent of the properties of the cornea. 
     During a non-contact IOP measurement, the cornea is deformed from its original convex state through a first state of applanation to a slightly concave state, and is allowed to return from concavity through a second state of applanation to convexity as the air pulse decays. Indeed, a second peak corresponding to the second state of applanation is known to occur in an applanation signal. U.S. Pat. No. 6,419,631 describes a non-contact tonometry method in which both a first plenum pressure P 1  and a second plenum pressure P 2  are used to calculate IOP. In one disclosed embodiment, a first IOP value (IOP 1 ) is calculated by inputting P 1  to a stored regression equation derived from a plot of clinical GAT measurements against P 1  measurements for a population of eyes, a second IOP value (IOP 2 ) is calculated by inputting P 2  to another stored regression equation derived from a plot of clinical GAT measurements against P 2  measurements for a population of eyes, and the two IOP values (IOP 1  and IOP 2 ) are averaged to yield a final result. In another disclosed embodiment, the pressures P 1  and P 2  are averaged and the result is input to a single stored regression equation derived from a plot of clinical GAT measurements against the average of P 1  and P 2  as measured for a population of eyes. A recent study of pre- and post-LASIK eyes demonstrates an unexpectedly large change in IOP after LASIK surgery when IOP is calculated according to this method, evidence that corneal effects continue to influence IOP measurement. 
     U.S. Pat. No. 6,817,981 describes a measurement approach intended to identify eyes having above-normal intraocular pressure. Under this approach, a standard NCT measurement of IOP is made and corneal hysteresis associated with the IOP measurement is found by calculating a pressure difference between the inward applanation pressure P 1  and the outward applanation pressure P 2 . The standard IOP measurement value and the corneal hysteresis define a point in two-dimensional space. The location of the point is then compared to a normality line or curve in the two-dimensional space defined by data points from a statistically significant population of eyes, whereby a difference of the measured IOP from an expected IOP for a given corneal hysteresis value can be observed. 
     The PASCAL® Dynamic Contour Tonometer developed by SMT Swiss Microtechnology AG is a contact tonometer designed to measure true IOP. The PASCAL® tonometer comprises a concave sensor tip intended to match the convex contour of the cornea. The sensor tip is spring loaded to provide constant appositional force to the cornea, and includes a solid state piezoresistive pressure sensor for continuously measuring IOP. 
     SUMMARY OF THE INVENTION 
     It is thus an object of the present invention to provide a non-contact tonometer capable of measuring true IOP. A related object of the invention is to measure true IOP by evaluating measurement results obtained using existing NCT technology in a novel manner. 
     These and other objects are achieved generally by a method of measuring intraocular pressure comprising the steps of A) directing a fluid pulse at a cornea to cause reversible deformation of the cornea from an original state of convexity through a first state of applanation to a state of concavity, and back through a second state of applanation to the state of convexity; B) acquiring a first pressure value (P 1 ) associated with the fluid pulse at a time of the first state of applanation and a second pressure value (P 2 ) associated with the fluid pulse at a time of the second state of applanation; and C) calculating an intraocular pressure value using a predetermined function of the first pressure value (P 1 ) and the second pressure value (P 2 ), wherein the function was empirically derived to minimize cornea-related influence on the intraocular pressure value. In an embodiment of the present invention, the empirically derived function is expressible as
 
IOP=K 1 *( F *P1+P2)+ K   2  
 
wherein F≠−0.43, and K 1  and K 2  are constants.
 
     The invention also comprises a non-contact tonometer programmed to carry out the method using the empirically derived function, which may be stored in instrument memory. 
     The invention further provides a method of deriving a function for calculating intraocular pressure generally comprising the steps of A) referencing empirical data taken with respect to a plurality of eyes, the empirical data measuring a first pressure value (P 1 ) associated with a first applanation of a cornea during a reversible deformation of the cornea and a second pressure value (P 2 ) associated with a second applanation of the cornea during the reversible deformation, the first and second pressure vales (P 1  and P 2 ) being obtained both before and after surgical alteration of the cornea for each of the plurality of eyes; B) choosing a form of the function wherein the first pressure value (P 1 ) and the second pressure value (P 2 ) are independently weighted variables; and C) determining relative weights of the first and second pressure values (P 1  and P 2 ) so as to minimize change in the intraocular pressure value between measurements made before surgical alteration of the cornea and measurements made after surgical alteration of the cornea. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       The nature and mode of operation of the present invention will now be more fully described in the following detailed description taken with the accompanying drawing figures, in which: 
         FIG. 1  is a schematic view of an NCT embodying the present invention; 
         FIGS. 2A through 2E  are a sequential series of views showing stages of deformation of a cornea during measurement of IOP in accordance with a method of the present invention; 
         FIG. 3  is a graph showing an applanation signal and a plenum pressure signal during an NCT measurement in accordance with the present invention; 
         FIG. 4  is a graph in which the absolute difference between pre- and post-LASIK IOP calculations is plotted as a function of a scale factor weighting a first plenum pressure value relative to a second plenum pressure value in the function used to calculate IOP; 
         FIG. 5  is a graph of central corneal thickness versus IOP for a population of normal eyes, where IOP is calculated according to an optimized function of the present invention; 
         FIG. 6  is a graph of central corneal thickness versus IOP for a population of glaucomatous eyes, where IOP is calculated according to an optimized function of the present invention; 
         FIG. 7  is a graph of IOP versus central corneal thickness for a population of eyes both with and without Iopidine-induced IOP reduction, where IOP is calculated according to an optimized function of the present invention; 
         FIG. 8  is a graph of average plenum pressure versus GAT measurement values for a population of eyes; 
         FIG. 9  is a flow chart illustrating a measurement process in accordance with an embodiment of the present invention; and 
         FIG. 10  is a graph showing post-LASIK IOP measurements made in accordance with the present invention plotted against pre-LASIK IOP measurements made in accordance with the present invention. 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
       FIG. 1  shows a non-contact tonometer  10  in schematic view. A test portion of NCT  10  is depicted as generally including a nosepiece  12  in which a fluid discharge tube  14  is fixed. The fluid discharge tube  14  defines a test axis TA that is aligned with a vertex of cornea C when measurement is carried out. The test portion of NCT  10  further includes a pump mechanism  16  having a plenum chamber  17  in flow communication with an entry end of fluid discharge tube  14 , a piston  18  movable to compress fluid within plenum chamber  17 , and a drive motor  20  connected to the piston. As will be familiar to persons skilled in the art of non-contact tonometry, the pump mechanism  16  is operable to rapidly increase fluid pressure within plenum chamber  17 , thereby generating a fluid pulse that is discharged from an exit end of fluid discharge tube  14  in the direction of cornea C to cause deformation of the cornea. In the depicted embodiment, motor  20  is energized by a current source  22  in response to a command signal from a microcontroller  24 . As used herein, the term “microcontroller” means any integrated circuit that includes at least a central processing unit (CPU) and a memory. The memory preferably includes a non-volatile memory device for retaining stored information when power is turned off. Suitable non-contact tonometers for practicing the present invention include, but are not limited to, the AT-555 Non-Contact Tonometer and the Ocular Response Analyzer (ORA) manufactured by Reichert, Inc., assignee of the present application. 
       FIGS. 2A-2E  show a corneal deformation cycle caused by the fluid pulse.  FIG. 2A  shows cornea C in its original and natural convex state.  FIG. 2B  shows cornea C in a first state of applanation as the cornea is pushed inwardly by the fluid pulse, and  FIG. 2C  shows cornea C in a concave state as the air pulse pushes the corneal tissue beyond its flattened state of  FIG. 2B . The air pulse then decays and the cornea is allowed to pass through a second state of applanation, shown in  FIG. 2D , as the cornea deforms in an outward direction to return to its original and natural convex state depicted again in  FIG. 2E . 
     Corneal deformation may be monitored by an optoelectronic monitoring system such as that shown in  FIG. 1 , wherein a light source  26  is obliquely aimed at the cornea, and a photosensitive detector  28  is arranged on an opposite side of the test axis TA to receive corneally reflected light. As will be understood, when cornea C is convex ( FIGS. 2A ,  2 E) or concave ( FIG. 2C ), a beam from light source  26  will become fanned out after reflection by the curved corneal surface and the signal generated by photosensitive detector  28  will be relatively weak. However, when cornea C is in an applanated state ( FIGS. 2B and 2D ), the light beam from light source  26  remains well-defined after reflection by the flattened corneal surface such that more light reaches photosensitive detector  28  and a peak signal is generated by the detector. The signal information generated by photosensitive detector  28  during the corneal deformation cycle, referred to herein as the “applanation signal,” is processed by a filter  30 , converted to digital form by analog-to-digital converter  32 , and input to microcontroller  24  where it may be stored by memory  34 . An applanation signal from a typical NCT measurement is plotted in  FIG. 3 , and includes a pair of well-defined signal peaks A 1  and A 2  corresponding to a first applanation event during inward deformation of cornea C (see  FIG. 2B ) and a second applanation event during outward deformation of cornea C (see  FIG. 2D ), respectively. 
     The pressure within plenum chamber  17  is also monitored during the corneal deformation cycle. In the embodiment shown, a pressure sensor  36  is positioned in plenum chamber  17  near the entry end of fluid discharge tube  14  to generate signal information representative of the plenum pressure associated with the fluid pulse. The signal information generated by pressure sensor  36  is processed by a filter  38 , converted to digital form by analog-to-digital converter  40 , and input to microcontroller  24  where it may be stored by memory  34 . A pressure signal from an NCT measurement according to the invention is plotted in  FIG. 3 , and is characterized by a Gaussian bell curve shape. It is preferable to adjust the parameters of pump mechanism  16  to provide a pressure signal that is at least approximately symmetrical about a moment in time and has a suitable spread, whereby a first pressure P 1  coinciding with first applanation A 1  and a second pressure P 2  coinciding with second applanation A 2  may be accurately determined by evaluating the applanation and pressure signals. For example, parameters that may be adjusted to optimize the shape of the pressure signal as a function of time include the weight of piston  18  and the time profile of the energizing current delivered by current source  22  to motor  20 . Evaluation of the applanation signal and pressure signal is performed by microcontroller  24 . 
     Thus, during a single corneal deformation cycle, two digital pressure values are obtained corresponding to the detected plenum pressure at the time of inward applanation ( FIG. 2B ) and at the time of outward applanation ( FIG. 2D ). For purposes of this specification, the first or inward pressure value is denoted P 1 , and the second or outward pressure value is denoted P 2 . The pressure values P 1  and P 2  are expressed in raw form as a digital “count” proportional to the amplitude of the pressure signal generated by pressure sensor  36 . 
     Based on analysis of data from various clinical trials, it was observed that pressure values P 1  and P 2  respond independently to various factors such as central corneal thickness, surgical alteration of the cornea, and clinically induced changes in IOP. Therefore, in accordance with the present invention, an “optimum combination” of the two independent parameters P 1  and P 2  was sought to yield the best IOP value. 
     More specifically, a function for calculating IOP from pressure values P 1  and P 2  was empirically derived from clinical data, wherein the function was optimized so as to minimize cornea-related influence on the calculated IOP value. In a current embodiment, clinical data comprising plenum pressure values P 1  and P 2  measured both before and after surgical alteration of the cornea in a plurality of eyes were used. The clinical data involved measurements taken before and after LASIK (Laser-Assisted In Situ Keratomileusis) surgery and are set forth in Table I below. 
                         TABLE I                  Pre-LASIK                             P1 bef         Post-LASIK                             (raw count)   P2 bef  (raw count)   P1 aft  (raw count)   P2 aft  (raw count)               249   168   203   147       247   166   196   141       269   181   209   149       286   194   197   152       200   111   179   105       210   128   182   114       229   175   182   146       231   158   197   154       246   171   217   163       227   146   187   123       227   139   175   111       257   148   177   120                    
In addition to the data shown in Table I above, further clinical data giving P 1 , P 2 , and central corneal thickness (CCT) for various populations of eyes were used.
 
     The function for calculating IOP was assumed to be a linear combination of pressure values P 1  and P 2 , and optimization was based on i) minimizing the difference between reported IOP measured before surgical alteration of the cornea and reported IOP measured after surgical alteration of the cornea, since theoretically, the corneal alteration should have essentially no effect on true IOP; and ii) minimizing statistical correlation between reported IOP and central corneal thickness, since true IOP is independent of central corneal thickness. As used herein, the term “minimize” and its alternate forms are used in a broad sense to include reducing a parameter. 
     Without loss of generality, the linear function for calculating IOP can be written
 
IOP= K   1 *( F *P1+P2)+ K   2   (1)
 
wherein “K 1 ” is slope, “K 2 ” is an offset determined by properties of the NCT measurement apparatus that influence the pressure signal, and “F” is a scale factor weighting P 1  relative to P 2 .
 
     Thus, the task of optimizing the above IOP function involves finding the value of scale factor F that minimizes the absolute value of the difference between pre-surgery and post-surgery IOP as calculated by the function. The value of F may be approximated by plotting ΔIOP, defined as
 
ΔIOP=|( F *P1 aft +P2 aft )−( F *P1 bef +P2 bef )|  (2)
 
against scale factor F and locating the minimum, where P 1   aft  is the average first pressure P 1  measured post-LASIK from Table I, P 2   aft  is the average second pressure P 2  measured post-LASIK from Table I, P 1   bef  is the average first pressure P 1  measured pre-LASIK from Table I, and P 2   bef  is the average second pressure P 2  measured pre-LASIK from Table I. Referring to Table II below, ΔIOP is calculated at incremental values of F, and a plot corresponding to Table II is provided at  FIG. 4 .
 
                                 TABLE II                       F   ΔIOP                                                    0.0   21.67           −0.1   16.86           −0.2   12.05           −0.3   7.24           −0.4   2.43           −0.5   2.38           −0.6   7.18           −0.7   11.99           −0.8   16.80           −0.9   21.61           −1.0   26.42                        
It is apparent from  FIG. 4  that a relatively well-defined minimum in the curve occurs very close to F=−0.45.
 
     The task of optimizing the IOP function of equation (1) may additionally involve adjusting F such that correlation between calculated IOP and central corneal thickness is essentially removed. Clinical data used for this adjustment included pressure and central corneal thickness data taken on a population of 184 normal eyes, a population of 319 glaucomatous eyes, and a population of 310 eyes measured both in their natural state and a state of lowered IOP induced by administering Iopidine to the eye. By plotting statistical correlation (R 2 ) as a function of scale factor F, it was found that a scale factor F=−0.43 essentially removed all statistical correlation between IOP and central corneal thickness in the population of Iopidine eyes (R 2 =0) and in the population of normal eyes (the population of normal eyes (R 2 =0.0006). With respect to the population of glaucomatous eyes, a scale factor F=−0.43 resulted in a slight statistical correlation between IOP and central corneal thickness (R 2 =0.1139). Plots demonstrating the lack of statistical correlation between calculated IOP and central corneal thickness for the three populations mentioned above are presented in  FIGS. 5 ,  6 , and  7 . Accordingly, the scale factor F was empirically optimized to be −0.43, such that
 
IOP= K   1 *(P2−0.43*P1)+ K   2   (3)
 
It is emphasized that error exists with respect to every measurement, and thus the empirically derived value of scale factor F may be expressed with an associated tolerance range. For present purposes, scale factor F=−0.43±0.1.
 
     As mentioned above, the values of K 1  and K 2  are specific to a given NCT, and therefore each NCT must be calibrated in order to provide accurate measurement results. One theoretical possibility for calibration is to determine K 1  and K 2  for each specific instrument by calibrating each instrument directly or indirectly against GAT. This may be done by measuring a plurality of eyes with GAT and measuring the same plurality of eyes with the instrument to be calibrated to obtain P 1  and P 2  raw count values for the same plurality of eyes. In an embodiment of the present invention, the data may then be evaluated through two regression steps. The first step is a normal linear regression of average plenum pressure (P 1 +P 2 )/2 against GAT values to find a scale factor relating pressure in arbitrary digital “count” units to an equivalent pressure in millimeters mercury and give a GAT-equivalent IOP (referred to herein as “IOPG”) from pressures P 1  and P 2 .  FIG. 8  shows a plot of (P 1 +P 2 )/2 versus GAT using data from a clinical study performed at the Wilmer Eye Institute at Johns Hopkins Hospital in Baltimore, Md. The study was performed using GAT and an NCT manufactured by Reichert, Inc., owner of the present application. Data were collected on 339 eyes ranging in GAT IOP reading from 3.0 mmHg to 57.3 mmHg. Two NCT measurements per eye and three GAT measurements per eye were taken with random right/left eye selection and random GAT—NCT sequence. The data are presented in Table III appearing at the end of this Detailed Description. Mathematically,
 
(P1+P2)/2=6.69*GAT+97.845  (4)
 
By definition, IOPG=GAT. Solving equation (4) for GAT provides IOPG in terms of P 1  and P 2  as follows:
 
IOPG=GAT=0.149*((P1+P2)/2)−15  (5)
 
     The second step is an orthogonal linear regression of (P 2 −0.43*P 1 ) against IOPG. By choosing scale factor K 1  such that the slope becomes 1, and forcing the y-intercept through 0, K 1  and K 2  are determined such that computed IOP is correlated to IOPG and thus ultimately to GAT. The orthogonal linear regression yielded IOP in millimeters mercury as a function of P 1  and P 2  as follows:
 
IOP=0.225*(P2−0.43 *P 1)+5.16  (6)
 
wherein 5.16 is a baseline corrected offset and P 1  and P 2  are baseline corrected pressure count values. Equation (6) applies for the particular NCT used in the clinical study.
 
     An alternative approach may be used based on a linear regression of (P 2 −0.43*P 1 ) directly against GAT, which will provide a slightly different but acceptable result. 
     Of course, it is highly impractical to calibrate each NCT intended for commercial sale in this manner. Instead, in order to calibrate each commercial NCT, a “master” NCT is calibrated as described above, and the calibrated master NCT is used as a reference standard for calibrating production NCTs intended for sale to customers. This latter step is preferably performed using a tonometer calibration tool and calibration methodology as described in commonly-owned U.S. Pat. No. 6,679,842. The tonometer calibration tool is used to determine an average value of P 1  (baseline corrected count) provided by the master NCT for each of three different calibration pressure settings A (low), B (medium), and C (high) of the tonometer calibration tool. These plenum pressure calibration values associated with the master NCT are designated P 1   A   M , P 1   B   M , and P 1   C   M , respectively. It is then necessary to determine an average value of P 1  (baseline corrected count) provided by a subject production NCT for each of the three different calibration pressure settings A (low), B (medium), and C (high) of the tonometer calibration tool. These plenum pressure calibration values associated with the production NCT are designated P 1   A   P , P 1   B   P , and P 1   C   P , respectively. Then, a linear regression of the production NCT pressure values versus the master NCT pressure values is performed:
 
(P1 A   P ,P1 B   P ,P1 C   P )≠m ABC *(P1 A   M ,P1 B   M ,P1 C   M )+b ABC   (7)
 
wherein m ABC  and b ABC  are calibration constants for the production NCT. The calibration constants m ABC  and b ABC  are used to convert the raw pressure values measured by a given production NCT into equivalent pressure values of the master NCT so that equation (6), derived for calculating IOP in the master NCT, is valid for calculating IOP in the production NCT. Accordingly, if the raw plenum pressure values measured by a production NCT are P 1   S  and P 2   S , then new calibration-converted plenum pressures  P 1     S  and  P 2     S  are calculated as follows:
 
  P1   S =(1/ m   ABC )*(P1 S   −b   ABC )  (8a)
 
  P2   S =(1/ m   ABC )*(P2 S   −b   ABC )  (8b)
 
     The converted pressure values  P 1     S  and  P 2     S  may then be inputted to equation (6) to calculate IOP:
 
IOP=0.225*(  P2   S −0.43*  P1   S )+5.16  (9)
 
     Thus, the parameters K 1  and K 2  derived for calculating IOP in the master NCT based on empirical data, and the calibration parameters m ABC  and b ABC  used for converting raw pressure values, are stored in memory  34  of each production instrument, along with programming code for performing the calculations set forth in equations (8a), (8b) and (9) above. 
       FIG. 9  is a flow chart showing the measurement process carried out by an NCT calibrated and programmed in accordance with the present invention. The test axis TA of the NCT is aligned with the patient&#39;s eye in step  100 , and a fluid pulse, for example an air puff, is directed at the cornea in step  102 . Blocks  104  and  106  represent generation of a pressure signal and applanation signal as described above with respect to  FIG. 3 . In step  108 , the pressure and applanation signals are digitized and the digitized signals are processed to determine pressure values P 1  and P 2 . The pressure values P 1  and P 2  are adjusted in step  110  based on calibration of the instrument as described above to yield calibration corrected pressure values  P 1    and  P 2   . In step  112  the calibration corrected pressure values  P 1    and  P 2    are input to the predetermined function for calculating IOP, which function may be stored in instrument memory, preferably non-volatile memory, during instrument calibration. Finally, the calculated IOP is reported in step  114 , for example by displaying, printing, or audibly reporting the IOP value. 
       FIG. 10  demonstrates the effectiveness of the present invention with respect to the data set of Table I above. Using the optimized function of the present invention, IOP measurements in units of mmHg taken before and after LASIK surgery for the population of eyes were strongly correlated (R 2 =0.95). As discussed above, this should be the case because each eye should have essentially constant IOP regardless of corneal shape or other corneal properties. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE III 
               
               
                   
               
               
                   
                   
                   
                   
                 (P1 + 
                 P2 − 
                   
               
               
                 GAT 
                 CCT - 
                 P1 - 
                 P2 - 
                 P2)/2 
                 .43 * P1 
                 IOPG 
               
               
                 (mmHg) 
                 (mm) 
                 (count) 
                 (count) 
                 (count) 
                 (count) 
                 (mmHg) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 15.6 
                 0.618 
                 246.7 
                 156.8 
                 201.7 
                 50.7 
                 15.2 
               
               
                 19.0 
                 0.611 
                 272.1 
                 175.4 
                 223.8 
                 58.4 
                 18.4 
               
               
                 26.0 
                 0.555 
                 333.9 
                 259.3 
                 296.6 
                 115.7 
                 29.3 
               
               
                 21.3 
                 0.515 
                 280.8 
                 217.5 
                 249.2 
                 96.7 
                 22.2 
               
               
                 21.3 
                 0.589 
                 267.8 
                 175.3 
                 221.5 
                 60.1 
                 18.1 
               
               
                 17.6 
                 0.510 
                 277.8 
                 223.7 
                 250.7 
                 104.2 
                 22.5 
               
               
                 27.3 
                 0.482 
                 282.1 
                 245.2 
                 263.6 
                 123.9 
                 24.4 
               
               
                 6.3 
                 0.618 
                 182.4 
                 97.4 
                 139.9 
                 19.0 
                 5.9 
               
               
                 6.0 
                 0.664 
                 190.7 
                 140.9 
                 165.8 
                 58.9 
                 9.8 
               
               
                 25.3 
                 0.568 
                 304.2 
                 230.1 
                 267.2 
                 99.3 
                 24.9 
               
               
                 25.3 
                 0.593 
                 324.5 
                 252.5 
                 288.5 
                 113.0 
                 28.1 
               
               
                 22.3 
                 0.513 
                 269.6 
                 209.7 
                 239.6 
                 93.8 
                 20.8 
               
               
                 13.3 
                 0.601 
                 207.3 
                 133.7 
                 170.5 
                 44.6 
                 10.5 
               
               
                 24.6 
                 0.598 
                 329.2 
                 260.1 
                 294.6 
                 118.5 
                 29.0 
               
               
                 12.3 
                 0.527 
                 232.1 
                 156.0 
                 194.0 
                 56.2 
                 14.0 
               
               
                 20.3 
                 0.585 
                 238.0 
                 158.3 
                 198.2 
                 56.0 
                 14.6 
               
               
                 18.3 
                 0.531 
                 245.1 
                 188.0 
                 216.6 
                 82.7 
                 17.4 
               
               
                 24.6 
                 0.533 
                 307.5 
                 223.9 
                 265.7 
                 91.6 
                 24.7 
               
               
                 18.6 
                 0.589 
                 267.9 
                 216.2 
                 242.1 
                 101.0 
                 21.2 
               
               
                 12.0 
                 0.485 
                 195.5 
                 144.7 
                 170.1 
                 60.6 
                 10.4 
               
               
                 19.6 
                 0.550 
                 238.5 
                 162.2 
                 200.4 
                 59.7 
                 15.0 
               
               
                 9.3 
                 0.556 
                 202.0 
                 137.8 
                 169.9 
                 51.0 
                 10.4 
               
               
                 19.3 
                 0.619 
                 250.6 
                 186.6 
                 218.6 
                 78.8 
                 17.7 
               
               
                 8.3 
                 0.578 
                 194.6 
                 120.1 
                 157.3 
                 36.4 
                 8.5 
               
               
                 10.6 
                 0.719 
                 193.2 
                 139.1 
                 166.2 
                 56.0 
                 9.8 
               
               
                 17.6 
                 0.544 
                 277.1 
                 203.1 
                 240.1 
                 83.9 
                 20.9 
               
               
                 15.3 
                 0.509 
                 217.2 
                 176.0 
                 196.6 
                 82.6 
                 14.4 
               
               
                 13.3 
                 0.556 
                 222.4 
                 179.8 
                 201.1 
                 84.2 
                 15.1 
               
               
                 10.3 
                 0.477 
                 214.5 
                 158.2 
                 186.4 
                 66.0 
                 12.9 
               
               
                 11.3 
                 0.562 
                 213.1 
                 142.0 
                 177.6 
                 50.4 
                 11.5 
               
               
                 13.0 
                 0.576 
                 246.4 
                 162.8 
                 204.6 
                 56.9 
                 15.6 
               
               
                 24.3 
                 0.516 
                 260.1 
                 217.1 
                 238.6 
                 105.2 
                 20.7 
               
               
                 27.0 
                 0.548 
                 299.8 
                 243.9 
                 271.9 
                 115.0 
                 25.6 
               
               
                 15.3 
                 0.591 
                 247.1 
                 158.9 
                 203.0 
                 52.7 
                 15.3 
               
               
                 31.3 
                 0.568 
                 335.5 
                 295.3 
                 315.4 
                 151.1 
                 32.1 
               
               
                 28.0 
                 0.542 
                 301.2 
                 238.9 
                 270.0 
                 109.4 
                 25.4 
               
               
                 18.6 
                 0.506 
                 236.5 
                 186.5 
                 211.5 
                 84.8 
                 16.6 
               
               
                 12.6 
                 0.564 
                 198.9 
                 122.4 
                 160.7 
                 36.9 
                 9.0 
               
               
                 18.0 
                 0.570 
                 258.7 
                 198.3 
                 228.5 
                 87.0 
                 19.1 
               
               
                 9.3 
                 0.502 
                 218.4 
                 126.9 
                 172.6 
                 33.0 
                 10.8 
               
               
                 15.3 
                 0.575 
                 272.8 
                 190.2 
                 231.5 
                 72.9 
                 19.6 
               
               
                 18.3 
                 0.551 
                 254.7 
                 174.9 
                 214.8 
                 65.4 
                 17.1 
               
               
                 10.0 
                 0.536 
                 214.7 
                 126.6 
                 170.7 
                 34.3 
                 10.5 
               
               
                 14.6 
                 0.498 
                 211.7 
                 166.6 
                 189.1 
                 75.5 
                 13.3 
               
               
                 18.0 
                 0.548 
                 223.1 
                 170.5 
                 196.8 
                 74.6 
                 14.4 
               
               
                 24.6 
                 0.575 
                 283.4 
                 200.6 
                 242.0 
                 78.7 
                 21.2 
               
               
                 18.0 
                 0.489 
                 248.9 
                 178.8 
                 213.9 
                 71.8 
                 17.0 
               
               
                 22.3 
                 0.586 
                 291.2 
                 191.8 
                 241.5 
                 66.6 
                 21.1 
               
               
                 18.3 
                 0.582 
                 263.5 
                 187.5 
                 225.5 
                 74.1 
                 18.7 
               
               
                 24.0 
                 0.552 
                 291.5 
                 263.2 
                 277.3 
                 137.8 
                 26.5 
               
               
                 10.6 
                 0.509 
                 201.0 
                 148.2 
                 174.6 
                 61.8 
                 11.1 
               
               
                 19.3 
                 0.590 
                 286.6 
                 222.0 
                 254.3 
                 98.8 
                 23.0 
               
               
                 20.3 
                 0.565 
                 259.2 
                 198.4 
                 228.8 
                 87.0 
                 19.2 
               
               
                 17.3 
                 0.656 
                 279.9 
                 210.5 
                 245.2 
                 90.2 
                 21.6 
               
               
                 15.3 
                 0.539 
                 232.2 
                 158.2 
                 195.2 
                 58.4 
                 14.2 
               
               
                 16.6 
                 0.641 
                 245.5 
                 189.7 
                 217.6 
                 84.1 
                 17.5 
               
               
                 11.3 
                 0.498 
                 201.8 
                 133.7 
                 167.7 
                 46.9 
                 10.1 
               
               
                 15.6 
                 0.571 
                 247.8 
                 171.3 
                 209.5 
                 64.7 
                 16.3 
               
               
                 18.6 
                 0.556 
                 252.2 
                 166.7 
                 209.4 
                 58.2 
                 16.3 
               
               
                 12.6 
                 0.543 
                 203.0 
                 132.9 
                 167.9 
                 45.6 
                 10.1 
               
               
                 22.3 
                 0.607 
                 323.2 
                 219.7 
                 271.4 
                 80.8 
                 25.6 
               
               
                 15.3 
                 0.543 
                 273.1 
                 188.2 
                 230.7 
                 70.8 
                 19.5 
               
               
                 13.0 
                 0.574 
                 247.3 
                 172.2 
                 209.7 
                 65.8 
                 16.3 
               
               
                 22.3 
                 0.656 
                 302.2 
                 231.4 
                 266.8 
                 101.5 
                 24.9 
               
               
                 12.0 
                 0.525 
                 213.0 
                 143.3 
                 178.1 
                 51.7 
                 11.6 
               
               
                 25.0 
                 0.618 
                 280.2 
                 206.0 
                 243.1 
                 85.5 
                 21.3 
               
               
                 13.3 
                 0.559 
                 176.3 
                 104.3 
                 140.3 
                 28.5 
                 6.0 
               
               
                 19.3 
                 0.564 
                 236.2 
                 163.7 
                 200.0 
                 62.1 
                 14.9 
               
               
                 23.6 
                 0.588 
                 252.4 
                 188.1 
                 220.3 
                 79.6 
                 17.9 
               
               
                 11.3 
                 0.542 
                 194.9 
                 131.2 
                 163.0 
                 47.3 
                 9.4 
               
               
                 18.3 
                 0.570 
                 251.4 
                 182.9 
                 217.2 
                 74.8 
                 17.5 
               
               
                 21.0 
                 0.612 
                 272.2 
                 204.3 
                 238.3 
                 87.3 
                 20.6 
               
               
                 21.3 
                 0.564 
                 292.9 
                 241.1 
                 267.0 
                 115.1 
                 24.9 
               
               
                 18.0 
                 0.521 
                 254.0 
                 189.2 
                 221.6 
                 80.0 
                 18.1 
               
               
                 25.3 
                 0.619 
                 298.9 
                 253.2 
                 276.1 
                 124.7 
                 26.3 
               
               
                 18.0 
                 0.541 
                 259.3 
                 170.9 
                 215.1 
                 59.4 
                 17.1 
               
               
                 15.6 
                 0.527 
                 239.6 
                 174.0 
                 206.8 
                 71.0 
                 15.9 
               
               
                 22.0 
                 0.563 
                 271.4 
                 191.0 
                 231.2 
                 74.3 
                 19.6 
               
               
                 20.3 
                 0.602 
                 310.3 
                 212.9 
                 261.6 
                 79.4 
                 24.1 
               
               
                 11.6 
                 0.581 
                 216.3 
                 144.7 
                 180.5 
                 51.7 
                 12.0 
               
               
                 25.3 
                 0.512 
                 285.2 
                 238.9 
                 262.0 
                 116.2 
                 24.2 
               
               
                 14.3 
                 0.554 
                 239.5 
                 165.0 
                 202.2 
                 62.0 
                 15.2 
               
               
                 5.6 
                 0.571 
                 157.9 
                 83.4 
                 120.7 
                 15.5 
                 3.0 
               
               
                 16.6 
                 0.609 
                 274.5 
                 200.4 
                 237.5 
                 82.4 
                 20.5 
               
               
                 19.0 
                 0.521 
                 254.7 
                 174.7 
                 214.7 
                 65.2 
                 17.1 
               
               
                 13.3 
                 0.548 
                 228.5 
                 159.2 
                 193.8 
                 61.0 
                 14.0 
               
               
                 20.6 
                 0.541 
                 254.8 
                 200.7 
                 227.7 
                 91.2 
                 19.0 
               
               
                 14.3 
                 0.600 
                 235.3 
                 181.0 
                 208.2 
                 79.8 
                 16.1 
               
               
                 15.0 
                 0.593 
                 261.0 
                 183.9 
                 222.5 
                 71.7 
                 18.3 
               
               
                 18.6 
                 0.547 
                 262.4 
                 198.8 
                 230.6 
                 86.0 
                 19.5 
               
               
                 18.6 
                 0.639 
                 292.9 
                 225.9 
                 259.4 
                 100.0 
                 23.8 
               
               
                 7.0 
                 0.529 
                 184.0 
                 111.4 
                 147.7 
                 32.3 
                 7.1 
               
               
                 10.3 
                 0.526 
                 210.7 
                 141.3 
                 176.0 
                 50.7 
                 11.3 
               
               
                 17.6 
                 0.500 
                 243.2 
                 176.1 
                 209.6 
                 71.5 
                 16.3 
               
               
                 12.6 
                 0.531 
                 226.8 
                 139.3 
                 183.0 
                 41.8 
                 12.4 
               
               
                 19.6 
                 0.541 
                 240.9 
                 178.4 
                 209.7 
                 74.8 
                 16.3 
               
               
                 25.6 
                 0.591 
                 313.6 
                 258.7 
                 286.2 
                 123.9 
                 27.8 
               
               
                 15.3 
                 0.492 
                 210.8 
                 162.7 
                 186.8 
                 72.1 
                 12.9 
               
               
                 26.3 
                 0.604 
                 339.3 
                 269.3 
                 304.3 
                 123.4 
                 30.5 
               
               
                 18.6 
                 0.508 
                 249.9 
                 189.4 
                 219.7 
                 82.0 
                 17.8 
               
               
                 6.3 
                 0.493 
                 164.5 
                 93.7 
                 129.1 
                 22.9 
                 4.3 
               
               
                 16.6 
                 0.585 
                 258.9 
                 188.9 
                 223.9 
                 77.6 
                 18.5 
               
               
                 19.0 
                 0.522 
                 232.8 
                 200.4 
                 216.6 
                 100.3 
                 17.4 
               
               
                 15.0 
                 0.481 
                 233.3 
                 174.0 
                 203.6 
                 73.7 
                 15.4 
               
               
                 12.0 
                 0.561 
                 228.4 
                 155.0 
                 191.7 
                 56.8 
                 13.7 
               
               
                 22.0 
                 0.566 
                 276.6 
                 217.5 
                 247.1 
                 98.5 
                 21.9 
               
               
                 24.3 
                 0.538 
                 261.3 
                 191.5 
                 226.4 
                 79.1 
                 18.8 
               
               
                 16.0 
                 0.554 
                 236.9 
                 175.8 
                 206.4 
                 73.9 
                 15.8 
               
               
                 17.6 
                 0.543 
                 282.6 
                 217.3 
                 249.9 
                 95.8 
                 22.4 
               
               
                 18.0 
                 0.541 
                 237.0 
                 179.6 
                 208.3 
                 77.7 
                 16.1 
               
               
                 15.0 
                 0.493 
                 242.1 
                 175.3 
                 208.7 
                 71.2 
                 16.2 
               
               
                 17.0 
                 0.616 
                 263.1 
                 186.6 
                 224.8 
                 73.5 
                 18.6 
               
               
                 28.3 
                 0.534 
                 294.3 
                 247.0 
                 270.6 
                 120.5 
                 25.5 
               
               
                 18.3 
                 0.575 
                 265.5 
                 196.0 
                 230.7 
                 81.8 
                 19.5 
               
               
                 21.0 
                 0.499 
                 269.1 
                 217.6 
                 243.3 
                 101.9 
                 21.4 
               
               
                 21.3 
                 0.591 
                 266.8 
                 206.7 
                 236.8 
                 91.9 
                 20.4 
               
               
                 17.3 
                 0.478 
                 250.5 
                 178.9 
                 214.7 
                 71.2 
                 17.1 
               
               
                 10.3 
                 0.575 
                 200.4 
                 136.3 
                 168.3 
                 50.1 
                 10.2 
               
               
                 20.0 
                 0.651 
                 245.7 
                 162.0 
                 203.8 
                 56.3 
                 15.5 
               
               
                 13.3 
                 0.499 
                 207.0 
                 149.3 
                 178.1 
                 60.3 
                 11.6 
               
               
                 18.0 
                 0.535 
                 255.4 
                 184.6 
                 220.0 
                 74.8 
                 17.9 
               
               
                 17.0 
                 0.576 
                 263.9 
                 179.8 
                 221.9 
                 66.3 
                 18.2 
               
               
                 16.6 
                 0.594 
                 250.7 
                 170.1 
                 210.4 
                 62.3 
                 16.5 
               
               
                 20.6 
                 0.594 
                 288.7 
                 216.3 
                 252.5 
                 92.2 
                 22.7 
               
               
                 5.3 
                 0.523 
                 145.8 
                 88.1 
                 116.9 
                 25.4 
                 2.5 
               
               
                 18.0 
                 0.557 
                 254.9 
                 193.8 
                 224.3 
                 84.2 
                 18.5 
               
               
                 4.3 
                 0.539 
                 163.6 
                 94.6 
                 129.1 
                 24.2 
                 4.3 
               
               
                 3.6 
                 0.559 
                 177.3 
                 85.6 
                 131.4 
                 9.4 
                 4.6 
               
               
                 23.0 
                 0.563 
                 304.3 
                 216.6 
                 260.4 
                 85.8 
                 23.9 
               
               
                 12.6 
                 0.499 
                 212.9 
                 139.5 
                 176.2 
                 48.0 
                 11.3 
               
               
                 20.3 
                 0.499 
                 242.1 
                 200.7 
                 221.4 
                 96.6 
                 18.1 
               
               
                 22.3 
                 0.628 
                 304.3 
                 236.5 
                 270.4 
                 105.7 
                 25.4 
               
               
                 27.3 
                 0.526 
                 289.3 
                 228.9 
                 259.1 
                 104.5 
                 23.7 
               
               
                 14.0 
                 0.588 
                 235.8 
                 156.0 
                 195.9 
                 54.6 
                 14.3 
               
               
                 16.0 
                 0.570 
                 247.4 
                 180.2 
                 213.8 
                 73.8 
                 17.0 
               
               
                 17.3 
                 0.535 
                 258.6 
                 193.7 
                 226.2 
                 82.5 
                 18.8 
               
               
                 20.3 
                 0.616 
                 261.5 
                 155.7 
                 208.6 
                 43.3 
                 16.2 
               
               
                 6.3 
                 0.570 
                 181.8 
                 112.5 
                 147.1 
                 34.4 
                 7.0 
               
               
                 16.3 
                 0.536 
                 236.0 
                 166.5 
                 201.3 
                 65.0 
                 15.1 
               
               
                 18.0 
                 0.568 
                 240.1 
                 168.2 
                 204.2 
                 65.0 
                 15.5 
               
               
                 13.0 
                 0.518 
                 219.7 
                 148.7 
                 184.2 
                 54.2 
                 12.5 
               
               
                 22.6 
                 0.571 
                 287.6 
                 255.3 
                 271.4 
                 131.6 
                 25.6 
               
               
                 9.0 
                 0.544 
                 210.1 
                 148.9 
                 179.5 
                 58.6 
                 11.8 
               
               
                 12.3 
                 0.505 
                 195.1 
                 137.6 
                 166.4 
                 53.7 
                 9.9 
               
               
                 26.3 
                 0.649 
                 369.0 
                 281.3 
                 325.2 
                 122.6 
                 33.6 
               
               
                 17.6 
                 0.560 
                 242.8 
                 168.5 
                 205.6 
                 64.1 
                 15.7 
               
               
                 13.3 
                 0.530 
                 208.6 
                 141.1 
                 174.8 
                 51.4 
                 11.1 
               
               
                 20.6 
                 0.600 
                 265.0 
                 180.3 
                 222.6 
                 66.4 
                 18.3 
               
               
                 12.0 
                 0.588 
                 220.4 
                 131.9 
                 176.2 
                 37.2 
                 11.3 
               
               
                 20.3 
                 0.557 
                 244.5 
                 180.8 
                 212.7 
                 75.6 
                 16.8 
               
               
                 10.6 
                 0.565 
                 200.3 
                 118.3 
                 159.3 
                 32.2 
                 8.8 
               
               
                 16.3 
                 0.525 
                 237.7 
                 177.2 
                 207.4 
                 75.0 
                 16.0 
               
               
                 57.6 
                 0.607 
                 518.6 
                 495.3 
                 507.0 
                 272.3 
                 60.8 
               
               
                 25.3 
                 0.558 
                 290.0 
                 209.6 
                 249.8 
                 84.9 
                 22.3 
               
               
                 21.3 
                 0.561 
                 271.1 
                 189.7 
                 230.4 
                 73.1 
                 19.4 
               
               
                 15.6 
                 0.586 
                 241.4 
                 165.9 
                 203.6 
                 62.1 
                 15.4 
               
               
                 17.3 
                 0.503 
                 237.6 
                 178.0 
                 207.8 
                 75.9 
                 16.1 
               
               
                 16.6 
                 0.513 
                 203.1 
                 124.2 
                 163.6 
                 36.9 
                 9.5 
               
               
                 21.0 
                 0.545 
                 283.4 
                 215.3 
                 249.3 
                 93.5 
                 22.3 
               
               
                 15.6 
                 0.591 
                 245.9 
                 165.2 
                 205.6 
                 59.4 
                 15.7 
               
               
                 20.3 
                 0.541 
                 261.5 
                 203.8 
                 232.7 
                 91.4 
                 19.8 
               
               
                 17.3 
                 0.528 
                 225.8 
                 159.5 
                 192.7 
                 62.4 
                 13.8 
               
               
                 17.0 
                 0.553 
                 271.0 
                 188.9 
                 230.0 
                 72.4 
                 19.4 
               
               
                 16.0 
                 0.477 
                 199.6 
                 143.7 
                 171.7 
                 57.9 
                 10.7 
               
               
                 15.3 
                 0.635 
                 250.0 
                 193.5 
                 221.8 
                 86.1 
                 18.1 
               
               
                 15.3 
                 0.476 
                 207.2 
                 153.0 
                 180.1 
                 63.9 
                 11.9 
               
               
                 12.0 
                 0.575 
                 187.4 
                 140.7 
                 164.0 
                 60.1 
                 9.5 
               
               
                 27.3 
                 0.603 
                 323.1 
                 257.2 
                 290.1 
                 118.3 
                 28.4 
               
               
                 24.6 
                 0.607 
                 306.7 
                 266.6 
                 286.7 
                 134.8 
                 27.8 
               
               
                 28.3 
                 0.594 
                 327.8 
                 274.5 
                 301.1 
                 133.6 
                 30.0 
               
               
                 22.6 
                 0.574 
                 272.6 
                 184.0 
                 228.3 
                 66.8 
                 19.1 
               
               
                 19.3 
                 0.523 
                 230.5 
                 156.8 
                 193.6 
                 57.6 
                 13.9 
               
               
                 18.3 
                 0.588 
                 280.2 
                 222.7 
                 251.4 
                 102.2 
                 22.6 
               
               
                 21.3 
                 0.606 
                 261.6 
                 170.7 
                 216.1 
                 58.2 
                 17.3 
               
               
                 27.0 
                 0.575 
                 289.6 
                 234.7 
                 262.2 
                 110.2 
                 24.2 
               
               
                 22.0 
                 0.522 
                 290.1 
                 225.1 
                 257.6 
                 100.4 
                 23.5 
               
               
                 21.3 
                 0.511 
                 269.4 
                 208.6 
                 239.0 
                 92.7 
                 20.7 
               
               
                 25.0 
                 0.478 
                 292.4 
                 245.4 
                 268.9 
                 119.6 
                 25.2 
               
               
                 3.3 
                 0.608 
                 151.2 
                 64.6 
                 107.9 
                 −0.4 
                 1.1 
               
               
                 21.0 
                 0.666 
                 248.2 
                 209.9 
                 229.1 
                 103.2 
                 19.2 
               
               
                 24.3 
                 0.566 
                 298.3 
                 246.6 
                 272.4 
                 118.3 
                 25.7 
               
               
                 30.0 
                 0.601 
                 342.6 
                 267.7 
                 305.1 
                 120.4 
                 30.6 
               
               
                 20.0 
                 0.517 
                 246.2 
                 189.2 
                 217.7 
                 83.3 
                 17.5 
               
               
                 18.3 
                 0.587 
                 231.1 
                 162.4 
                 196.8 
                 63.1 
                 14.4 
               
               
                 21.3 
                 0.610 
                 280.8 
                 201.4 
                 241.1 
                 80.6 
                 21.0 
               
               
                 14.3 
                 0.559 
                 257.1 
                 204.8 
                 231.0 
                 94.3 
                 19.5 
               
               
                 14.0 
                 0.572 
                 223.1 
                 148.9 
                 186.0 
                 53.0 
                 12.8 
               
               
                 17.3 
                 0.534 
                 236.2 
                 170.9 
                 203.5 
                 69.3 
                 15.4 
               
               
                 22.6 
                 0.541 
                 277.4 
                 198.0 
                 237.7 
                 78.7 
                 20.5 
               
               
                 19.0 
                 0.589 
                 268.0 
                 188.8 
                 228.4 
                 73.6 
                 19.1 
               
               
                 13.3 
                 0.500 
                 209.7 
                 165.8 
                 187.8 
                 75.6 
                 13.1 
               
               
                 5.6 
                 0.582 
                 188.6 
                 118.2 
                 153.4 
                 37.1 
                 7.9 
               
               
                 20.3 
                 0.524 
                 240.7 
                 181.8 
                 211.2 
                 78.3 
                 16.6 
               
               
                 22.3 
                 0.592 
                 287.7 
                 218.3 
                 253.0 
                 94.5 
                 22.8 
               
               
                 15.3 
                 0.576 
                 259.1 
                 180.8 
                 219.9 
                 69.4 
                 17.9 
               
               
                 19.0 
                 0.564 
                 243.4 
                 187.4 
                 215.4 
                 82.7 
                 17.2 
               
               
                 14.0 
                 0.556 
                 249.5 
                 163.7 
                 206.6 
                 56.4 
                 15.9 
               
               
                 10.3 
                 0.499 
                 192.3 
                 127.1 
                 159.7 
                 44.5 
                 8.9 
               
               
                 20.0 
                 0.580 
                 215.7 
                 134.7 
                 175.2 
                 41.9 
                 11.2 
               
               
                 18.3 
                 0.470 
                 258.0 
                 224.6 
                 241.3 
                 113.7 
                 21.1 
               
               
                 13.0 
                 0.544 
                 225.8 
                 161.5 
                 193.6 
                 64.4 
                 13.9 
               
               
                 13.6 
                 0.577 
                 242.0 
                 169.6 
                 205.8 
                 65.6 
                 15.8 
               
               
                 20.6 
                 0.606 
                 220.5 
                 197.8 
                 209.1 
                 102.9 
                 16.3 
               
               
                 31.6 
                 0.541 
                 303.6 
                 225.8 
                 264.7 
                 95.3 
                 24.6 
               
               
                 30.3 
                 0.581 
                 356.1 
                 291.9 
                 324.0 
                 138.8 
                 33.4 
               
               
                 24.0 
                 0.560 
                 288.9 
                 211.5 
                 250.2 
                 87.3 
                 22.4 
               
               
                 18.0 
                 0.581 
                 243.3 
                 194.0 
                 218.6 
                 89.4 
                 17.7 
               
               
                 20.6 
                 0.536 
                 248.4 
                 186.3 
                 217.4 
                 79.5 
                 17.5 
               
               
                 37.0 
                 0.516 
                 328.8 
                 277.0 
                 302.9 
                 135.7 
                 30.3 
               
               
                 15.3 
                 0.547 
                 211.7 
                 125.0 
                 168.3 
                 33.9 
                 10.2 
               
               
                 16.6 
                 0.563 
                 241.6 
                 177.9 
                 209.8 
                 74.1 
                 16.4 
               
               
                 10.6 
                 0.501 
                 212.1 
                 139.9 
                 176.0 
                 48.7 
                 11.3 
               
               
                 18.6 
                 0.594 
                 277.3 
                 207.5 
                 242.4 
                 88.2 
                 21.2 
               
               
                 18.0 
                 0.564 
                 256.3 
                 180.5 
                 218.4 
                 70.3 
                 17.6 
               
               
                 9.6 
                 0.549 
                 213.2 
                 125.5 
                 169.3 
                 33.8 
                 10.3 
               
               
                 14.6 
                 0.518 
                 211.0 
                 139.4 
                 175.2 
                 48.7 
                 11.2 
               
               
                 18.3 
                 0.556 
                 233.1 
                 166.0 
                 199.5 
                 65.8 
                 14.8 
               
               
                 19.3 
                 0.571 
                 253.5 
                 172.5 
                 213.0 
                 63.5 
                 16.8 
               
               
                 20.3 
                 0.494 
                 242.6 
                 164.6 
                 203.6 
                 60.3 
                 15.4 
               
               
                 23.3 
                 0.575 
                 298.9 
                 193.3 
                 246.1 
                 64.8 
                 21.8 
               
               
                 20.0 
                 0.583 
                 249.4 
                 168.3 
                 208.8 
                 61.1 
                 16.2 
               
               
                 19.0 
                 0.538 
                 261.6 
                 192.2 
                 226.9 
                 79.7 
                 18.9 
               
               
                 18.3 
                 0.509 
                 247.6 
                 205.5 
                 226.6 
                 99.0 
                 18.9 
               
               
                 12.6 
                 0.596 
                 251.1 
                 167.0 
                 209.0 
                 59.0 
                 16.2 
               
               
                 20.6 
                 0.552 
                 284.2 
                 226.2 
                 255.2 
                 104.0 
                 23.1 
               
               
                 17.6 
                 0.634 
                 269.4 
                 204.6 
                 237.0 
                 88.8 
                 20.4 
               
               
                 16.3 
                 0.536 
                 236.1 
                 153.3 
                 194.7 
                 51.8 
                 14.1 
               
               
                 12.6 
                 0.616 
                 259.9 
                 211.0 
                 235.4 
                 99.3 
                 20.2 
               
               
                 10.0 
                 0.493 
                 178.4 
                 113.9 
                 146.2 
                 37.2 
                 6.8 
               
               
                 19.3 
                 0.570 
                 250.6 
                 176.0 
                 213.3 
                 68.2 
                 16.9 
               
               
                 19.0 
                 0.554 
                 259.5 
                 184.5 
                 222.0 
                 73.0 
                 18.2 
               
               
                 13.6 
                 0.554 
                 213.2 
                 147.8 
                 180.5 
                 56.2 
                 12.0 
               
               
                 23.0 
                 0.603 
                 324.6 
                 220.6 
                 272.6 
                 81.1 
                 25.7 
               
               
                 19.6 
                 0.549 
                 271.8 
                 187.7 
                 229.7 
                 70.8 
                 19.3 
               
               
                 14.0 
                 0.578 
                 262.8 
                 168.1 
                 215.4 
                 55.1 
                 17.2 
               
               
                 24.3 
                 0.678 
                 307.0 
                 263.9 
                 285.5 
                 131.9 
                 27.7 
               
               
                 11.0 
                 0.536 
                 215.7 
                 139.4 
                 177.6 
                 46.6 
                 11.5 
               
               
                 29.0 
                 0.610 
                 291.1 
                 232.3 
                 261.7 
                 107.1 
                 24.1 
               
               
                 13.3 
                 0.519 
                 192.4 
                 119.6 
                 156.0 
                 36.9 
                 8.3 
               
               
                 15.6 
                 0.582 
                 207.1 
                 131.5 
                 169.3 
                 42.5 
                 10.3 
               
               
                 21.6 
                 0.570 
                 261.0 
                 185.8 
                 223.4 
                 73.6 
                 18.4 
               
               
                 14.6 
                 0.562 
                 216.8 
                 152.8 
                 184.8 
                 59.6 
                 12.6 
               
               
                 19.3 
                 0.569 
                 247.0 
                 180.2 
                 213.6 
                 74.0 
                 16.9 
               
               
                 22.0 
                 0.627 
                 298.4 
                 226.4 
                 262.4 
                 98.1 
                 24.2 
               
               
                 18.3 
                 0.536 
                 305.7 
                 191.2 
                 248.5 
                 59.7 
                 22.1 
               
               
                 20.6 
                 0.523 
                 268.5 
                 215.4 
                 242.0 
                 99.9 
                 21.2 
               
               
                 22.6 
                 0.616 
                 288.6 
                 249.7 
                 269.1 
                 125.6 
                 25.2 
               
               
                 20.0 
                 0.539 
                 239.4 
                 155.9 
                 197.6 
                 53.0 
                 14.5 
               
               
                 16.3 
                 0.539 
                 230.8 
                 162.3 
                 196.6 
                 63.1 
                 14.4 
               
               
                 25.0 
                 0.560 
                 239.1 
                 158.8 
                 199.0 
                 56.0 
                 14.7 
               
               
                 22.6 
                 0.617 
                 326.7 
                 219.2 
                 273.0 
                 78.8 
                 25.8 
               
               
                 16.6 
                 0.599 
                 277.5 
                 188.9 
                 233.2 
                 69.6 
                 19.9 
               
               
                 19.6 
                 0.526 
                 223.0 
                 167.4 
                 195.2 
                 71.6 
                 14.2 
               
               
                 14.3 
                 0.544 
                 242.1 
                 173.2 
                 207.7 
                 69.1 
                 16.0 
               
               
                 20.0 
                 0.557 
                 275.3 
                 207.5 
                 241.4 
                 89.1 
                 21.1 
               
               
                 9.6 
                 0.621 
                 205.4 
                 117.9 
                 161.7 
                 29.6 
                 9.2 
               
               
                 19.0 
                 0.525 
                 247.6 
                 155.3 
                 201.5 
                 48.8 
                 15.1 
               
               
                 14.6 
                 0.558 
                 226.9 
                 150.2 
                 188.5 
                 52.6 
                 13.2 
               
               
                 22.6 
                 0.522 
                 276.4 
                 206.3 
                 241.3 
                 87.4 
                 21.1 
               
               
                 15.6 
                 0.596 
                 239.6 
                 179.7 
                 209.6 
                 76.7 
                 16.3 
               
               
                 15.3 
                 0.596 
                 262.4 
                 179.2 
                 220.8 
                 66.4 
                 18.0 
               
               
                 34.6 
                 0.539 
                 345.8 
                 305.2 
                 325.5 
                 156.5 
                 33.7 
               
               
                 21.6 
                 0.599 
                 314.8 
                 247.2 
                 281.0 
                 111.8 
                 27.0 
               
               
                 10.0 
                 0.515 
                 211.5 
                 143.6 
                 177.6 
                 52.7 
                 11.5 
               
               
                 14.6 
                 0.499 
                 247.4 
                 188.7 
                 218.1 
                 82.3 
                 17.6 
               
               
                 18.3 
                 0.532 
                 263.1 
                 191.2 
                 227.2 
                 78.0 
                 19.0 
               
               
                 18.6 
                 0.527 
                 247.5 
                 175.1 
                 211.3 
                 68.7 
                 16.6 
               
               
                 32.3 
                 0.593 
                 343.3 
                 274.9 
                 309.1 
                 127.3 
                 31.2 
               
               
                 17.6 
                 0.513 
                 214.4 
                 162.6 
                 188.5 
                 70.4 
                 13.2 
               
               
                 24.3 
                 0.601 
                 307.7 
                 241.7 
                 274.7 
                 109.3 
                 26.1 
               
               
                 16.6 
                 0.500 
                 238.2 
                 174.2 
                 206.2 
                 71.8 
                 15.8 
               
               
                 16.3 
                 0.477 
                 200.0 
                 148.0 
                 174.0 
                 62.0 
                 11.0 
               
               
                 15.0 
                 0.574 
                 270.4 
                 173.9 
                 222.2 
                 57.7 
                 18.2 
               
               
                 16.6 
                 0.513 
                 223.9 
                 158.7 
                 191.3 
                 62.5 
                 13.6 
               
               
                 16.0 
                 0.494 
                 258.9 
                 196.1 
                 227.5 
                 84.8 
                 19.0 
               
               
                 17.0 
                 0.563 
                 268.6 
                 186.7 
                 227.6 
                 71.2 
                 19.0 
               
               
                 23.6 
                 0.567 
                 269.4 
                 205.5 
                 237.4 
                 89.7 
                 20.5 
               
               
                 18.6 
                 0.523 
                 260.7 
                 182.9 
                 221.8 
                 70.8 
                 18.2 
               
               
                 11.3 
                 0.526 
                 206.3 
                 137.8 
                 172.1 
                 49.1 
                 10.7 
               
               
                 20.6 
                 0.547 
                 280.3 
                 209.3 
                 244.8 
                 88.8 
                 21.6 
               
               
                 21.6 
                 0.560 
                 258.3 
                 199.1 
                 228.7 
                 88.1 
                 19.2 
               
               
                 14.3 
                 0.490 
                 229.1 
                 175.1 
                 202.1 
                 76.6 
                 15.2 
               
               
                 14.3 
                 0.592 
                 258.5 
                 182.5 
                 220.5 
                 71.3 
                 18.0 
               
               
                 23.3 
                 0.533 
                 270.2 
                 187.0 
                 228.6 
                 70.8 
                 19.2 
               
               
                 18.3 
                 0.572 
                 252.2 
                 173.9 
                 213.1 
                 65.5 
                 16.9 
               
               
                 20.0 
                 0.504 
                 246.0 
                 193.7 
                 219.9 
                 88.0 
                 17.9 
               
               
                 21.3 
                 0.573 
                 283.9 
                 211.7 
                 247.8 
                 89.6 
                 22.0 
               
               
                 17.0 
                 0.476 
                 240.1 
                 164.2 
                 202.2 
                 61.0 
                 15.2 
               
               
                 39.0 
                 0.566 
                 377.8 
                 338.3 
                 358.1 
                 175.9 
                 38.5 
               
               
                 15.0 
                 0.506 
                 206.0 
                 134.6 
                 170.3 
                 46.0 
                 10.5 
               
               
                 19.3 
                 0.534 
                 254.5 
                 188.3 
                 221.4 
                 78.9 
                 18.1 
               
               
                 15.6 
                 0.576 
                 281.4 
                 202.0 
                 241.7 
                 81.0 
                 21.1 
               
               
                 21.6 
                 0.611 
                 301.2 
                 238.2 
                 269.7 
                 108.6 
                 25.3 
               
               
                 19.6 
                 0.609 
                 272.5 
                 207.9 
                 240.2 
                 90.7 
                 20.9 
               
               
                 24.6 
                 0.516 
                 269.2 
                 214.8 
                 242.0 
                 99.1 
                 21.2 
               
               
                 17.6 
                 0.562 
                 259.6 
                 185.8 
                 222.7 
                 74.2 
                 18.3 
               
               
                 20.0 
                 0.546 
                 255.8 
                 196.2 
                 226.0 
                 86.2 
                 18.8 
               
               
                 17.3 
                 0.544 
                 260.5 
                 171.8 
                 216.1 
                 59.8 
                 17.3 
               
               
                 22.0 
                 0.557 
                 289.8 
                 203.2 
                 246.5 
                 78.5 
                 21.8 
               
               
                 13.6 
                 0.513 
                 215.8 
                 142.4 
                 179.1 
                 49.6 
                 11.8 
               
               
                 13.6 
                 0.486 
                 196.6 
                 138.9 
                 167.7 
                 54.4 
                 10.1 
               
               
                 29.0 
                 0.624 
                 348.8 
                 295.2 
                 322.0 
                 145.2 
                 33.1 
               
               
                 25.6 
                 0.542 
                 309.6 
                 255.2 
                 282.4 
                 122.1 
                 27.2 
               
               
                 16.0 
                 0.581 
                 243.0 
                 178.5 
                 210.8 
                 74.0 
                 16.5 
               
               
                 12.3 
                 0.592 
                 249.6 
                 179.0 
                 214.3 
                 71.7 
                 17.0 
               
               
                 21.0 
                 0.534 
                 264.2 
                 208.6 
                 236.4 
                 94.9 
                 20.3 
               
               
                 19.0 
                 0.611 
                 261.1 
                 167.9 
                 214.5 
                 55.7 
                 17.1 
               
               
                 8.6 
                 0.582 
                 176.5 
                 100.9 
                 138.7 
                 25.1 
                 5.7 
               
               
                 16.6 
                 0.528 
                 242.5 
                 175.5 
                 209.0 
                 71.2 
                 16.2 
               
               
                 18.0 
                 0.573 
                 228.8 
                 158.1 
                 193.4 
                 59.8 
                 13.9 
               
               
                 18.3 
                 0.518 
                 241.2 
                 179.8 
                 210.5 
                 76.1 
                 16.5 
               
               
                 23.3 
                 0.566 
                 310.2 
                 236.8 
                 273.5 
                 103.4 
                 25.9 
               
               
                 9.6 
                 0.526 
                 184.4 
                 127.9 
                 156.2 
                 48.6 
                 8.3 
               
               
                 5.6 
                 0.379 
                 140.0 
                 84.5 
                 112.2 
                 24.3 
                 1.8 
               
               
                 22.6 
                 0.651 
                 304.5 
                 247.4 
                 275.9 
                 116.5 
                 26.2 
               
               
                 4.0 
                 0.543 
                 152.3 
                 69.0 
                 110.7 
                 3.5 
                 1.5 
               
               
                 13.0 
                 0.525 
                 223.1 
                 163.4 
                 193.2 
                 67.5 
                 13.9 
               
               
                 21.3 
                 0.577 
                 268.3 
                 181.9 
                 225.1 
                 66.5 
                 18.6 
               
               
                 20.3 
                 0.546 
                 235.4 
                 181.3 
                 208.4 
                 80.0 
                 16.1 
               
               
                 11.6 
                 0.566 
                 205.5 
                 125.7 
                 165.6 
                 37.3 
                 9.8 
               
               
                 17.3 
                 0.546 
                 256.8 
                 184.3 
                 220.6 
                 73.9 
                 18.0 
               
               
                 57.3 
                 0.618 
                 530.3 
                 490.5 
                 510.4 
                 262.4 
                 61.3 
               
               
                 21.3 
                 0.561 
                 263.9 
                 188.8 
                 226.4 
                 75.4 
                 18.8 
               
               
                 17.3 
                 0.575 
                 260.7 
                 185.4 
                 223.0 
                 73.3 
                 18.3 
               
               
                 13.6 
                 0.486 
                 203.1 
                 138.7 
                 170.9 
                 51.4 
                 10.5 
               
               
                 17.3 
                 0.511 
                 216.6 
                 161.7 
                 189.1 
                 68.5 
                 13.3 
               
               
                 27.0 
                 0.590 
                 327.2 
                 267.3 
                 297.2 
                 126.6 
                 29.4 
               
               
                 12.3 
                 0.732 
                 238.3 
                 158.8 
                 198.5 
                 56.4 
                 14.7 
               
               
                 30.3 
                 0.519 
                 340.9 
                 306.9 
                 323.9 
                 160.3 
                 33.4 
               
               
                 25.6 
                 0.526 
                 283.7 
                 250.1 
                 266.9 
                 128.1 
                 24.9 
               
               
                 17.6 
                 0.548 
                 276.6 
                 187.5 
                 232.0 
                 68.5 
                 19.7 
               
               
                 14.0 
                 0.457 
                 207.9 
                 161.8 
                 184.8 
                 72.4 
                 12.6 
               
               
                 18.3 
                 0.612 
                 277.3 
                 210.7 
                 244.0 
                 91.5 
                 21.5 
               
               
                 12.6 
                 0.519 
                 218.8 
                 152.4 
                 185.6 
                 58.4 
                 12.7 
               
               
                 18.6 
                 0.594 
                 264.2 
                 197.3 
                 230.7 
                 83.7 
                 19.5 
               
               
                 25.0 
                 0.601 
                 287.8 
                 226.3 
                 257.1 
                 102.5 
                 23.4 
               
               
                 25.3 
                 0.615 
                 301.6 
                 239.0 
                 270.3 
                 109.3 
                 25.4 
               
               
                 35.6 
                 0.598 
                 368.5 
                 323.3 
                 345.9 
                 164.9 
                 36.7 
               
               
                 20.0 
                 0.531 
                 229.7 
                 150.5 
                 190.1 
                 51.7 
                 13.4