Patent Publication Number: US-4322528-A

Title: Polycyclic chlorinated hydrocarbons containing bridgehead or imino nitrogen

Description:
This is a division of application Ser. No. 7979, filed Jan 31, 1979, now U.S. Pat. No. 4,228,078, which is a division of application Ser. No. 878,794, filed Feb. 17, 1978, now U.S. Pat. No. 4,182,884, which is a division of application Ser. No. 725,578, filed Sept. 22, 1976, now U.S. Pat. No. 4,087,434. 
    
    
     BACKGROUND OF THE INVENTION 
     A well-known class of insecticides includes the polychlorinated cyclic hydrocarbons with endomethylenebridged structures. Most of these compounds are prepared by the well-known Diols-Alder [4+2] cycloaddition reaction. 
     The tradenames of various of these insecticides are: Chlordane, Heptachlor, Heptachlor epoxide, Betadihydroheptachlor, Telodrin, Aldrin, Dieldrin, Endrin, Endosulfan (Thiodane), Aldodan, Mirex and Nonachlor. 
     These insecticides are conventionally used for the control of cockroaches, ants, termites and other household pests, soil insects and a variety of vegetable and field crop pests. They are good contact insecticides whose symptoms of poisoning include disturbance of the ganglia of the central nervous system upon absorption by the insect. 
     In U.S. applications Ser. Nos. 454,576 (filed Mar. 25, 1974 in the name of Wong, and now abandoned), and 672,322, filed Mar. 31, 1976, now U.S. Pat. No. 4,081,448, there is disclosed a class of compounds possessing an activity similar to the polychlorinated cyclic hydrocarbons. These compounds are, for the most part, the bridgehead nitrogen analogs of the above-noted commercial insecticides. However, they are advantageous in many respects, one being that they are more readily degraded after performing their function thereby lessening the deleterious impact on the environment. 
     SUMMARY OF THE INVENTION 
     The present invention relates to a novel class of compounds possessing an insecticidal activity similar to the polychlorinated cyclic hydrocarbons. They usually contain a nitrogen in the ring system. The presence of the hetero-N atom has several favorable effects on the insecticidal function of the compound. 
     The compounds of the present invention may be prepared by reacting pentachloro-α-pyrrolenine with itself or an appropriate olefin in a cycloaddition reaction, followed by, in some cases, further treatment to yield a desired derivative. 
     DETAILED DESCRIPTION OF THE INVENTION 
     The commercial chlorinated hydrocarbon insecticides have been found to be disadvantageous due to the accumulation of their residues in the environment posing a threat to the general health. As a consequence, the use of the commercial insecticides has been stringently regulated on both the Federal and State levels, thereby severely limiting their applicability. In addition, test colonies have developed widespread resistance to the above-described chlorinated hydrocarbon insecticides, thereby further restricting their applicability. 
     The polycyclic amines of the present invention lend themselves to relatively easy hydrolysis at the bridgehead nitrogen due to the presence of the N--CCl 2  moiety to an amino acid which may be biodegraded further. This biodegradation pathway is unavailable to the above-described commercial insecticides and is highly advantageous in that it solves the notorious residue problem associated with the latter. Also, the lone pair electrons of the nitrogen of these amines will enhance the hydrophilicity as well as the complexation equilibrium constant to the ganglia reception sites via hydrogen bonding. This will have a favorable impact on the transport and the pharmacological effects of the insecticide on the nervous system of the insects. 
     It has been found that many of the polycyclic amines described in the above-mentioned copending applications are much less toxic than their non-nitrogenous commercial analogs on dermal application to rats. The presence of the hetero nitrogen atom apparently reduces the hazard to users of the insecticides and to wildlife. These advantages, coupled with the fact that the amino analogs differ in structure and properties from the chlorinated hydrocarbons, reduces the problem of build-up pest resistance considerably. 
    
    
     The compounds of the invention may be prepared by cycloaddition reactions employing pentachloro-α-pyrrolenine and the appropriate olefin. The reaction conditions required for producing the required product depend in each case upon the reactants employed. The following non-limiting Examples are set forth to show the methods of preparation of the compounds of the invention. 
     The reaction of most olefins with pentachloro-α-pyrrolenine produces a reaction product comprising a 1-azapentachlorobicyclo [2.2.1] hept-2-ene nucleus with the substituent attached to the vinyl group in the olefin reactant occupying either the 5 or 6 position. In some instances a mixture of the two regioisomers is produced. It is impossible in some instances to preclude by analysis the existence of one of the regioisomers in the reaction mixture. In each of the following examples a diligent effort was made to correctly characterize the product. It is to be understood, however, by those skilled in the art that the crude reaction product in those examples specifying a single isomer may also additionally contain minor amounts of the regioisomer. 
     EXAMPLE 1 
     This Example illustrates the following equation: ##STR1## 
     Pentachloro-α-pyrrolenine [1.17 g, 4.9 mmole] and vinyl chloride [0.62 g, 9.9 mmole] were dissolved in 5.6 ml of toluene and heated in a sealed tube at 110° C. for 96 hours. The reaction mixture was decolorized with activated charcoal and the toluene removed in vacuuo. The yellow semi-solid residue was recrystallized from a methylene chloride-pentane mixture to yield 0.78 g (53%) of white crystalline-1-aza-2,3,4,5 (endo),7,7-hexachlorobicyclo[2,2,1]hept-2-ene having a m.p. 77°-79° C.;  1  H NMR δ(CDCl 3 ,δTMS=0)2.43 (q,J3Hz,1H), 3.25 (q,J8Hz, 1H), and 4.70 (q,J3Hz, 1H). 
     Anal. Calcd. for C 6  H 3  N Cl 6  : C, 23.84; H, 0.99; N, 4.64. Found: C, 23.80; H, 1.02; N, 4.56. 
     EXAMPLE 2 
     A mixture of 2 g (8.4 mmol) of pentachloro-α-pyrrolenine and 0.556 g (8.4 mmol) of cyclopentadiene was allowed to stand at room temperature overnight. The reaction mixture was dissolved in 50% aqueous ethanol and cooled. The precipitate was recovered and sublimed at 55° C., 0.1 mm to yield 1.9 g (74%) of 2-aza-3,3,4,5,6-pentachlorotricyclo [5.2.1.0 2 ,6 ]deca-4,8-diene, ##STR2## m.p. 173°-174° C. 
     Anal. Calcd for C 9  H 6  N Cl 5  : C, 35.35; H, 1.96; N, 4.58. Found: C, 35.36; H, 1.94; N, 4.46. 
     A mixture of 5.0 g (16.37 mmol) of the above compound and 3.02 g (17.5 mmol of m-chloroperbenzoic acid in 25 ml of chloroform was stirred at room temperature for 14 days. The reaction mixture was extracted successively with 3×3 ml of 5% aqueous sodium bisulfite solution and 3×3 ml of 5% aqueous sodium bicarbonate solution. The organic layer was dried, evaporated, and the residue recrystallized three times from ether, yielding 3.40 g of 2-aza-8,9-epoxy-3,3,4,5,6-pentachlorotricyclo[5.2.1.0 2 .6 ] dec-4-ene, m.p. 90° s;  1  H NMR δ(CDCl 3  --TMS) 3.62-3.43 (m,2H), 3.23 (m,1H), 2.91 (m,1H), 2.12-1.83 (m,2H): ##STR3## 
     Anal. Calcd for C 9  H 6  NOCl 5  : C, 33.63; H, 1.88; N,4.36. Found: C, 34.07; H, 2.33; N, 4.12. 
     10 g of the above compound (30 mmole) were heated in 10 one-gram batches in sealed tubes at 140° C. for 17 hours. 
     The reaction produces a mixture containing substantially equal amounts of the following alcohols a and b: ##STR4## The products may be separated according to the following procedure 
     The light brown, gummy residue of each tube was dissolved in separate 20 ml batches of CHCl 3 . 0.280 g of active MnO 2  was added to each batch. The heterogeneous reaction mixtures were shaken for two hours, filtered, combined and stripped to dryness. The residue, 9.88 g, was diluted to 10 ml with 95% EtOH and divided into 10 one-ml portions. To each portion was added 10.4 ml of fresh 2,4-dinitrophenylhydrazine (DNP) reagent (20 mg/ml)(0.53 eq). The resulting precipitates were filtered off, washed with 5 ml of cold EtOH and air-dried. The yield was 6.38 g of the dinitrophenylhydrazone of the enone formed by the above oxidation of the mixture of alcohols. The hydrazone was recrystallized 5 times from 95% EtOH, m.p. 251°-252° C., and converted to the enone as shown in the equation below. ##STR5## 
     To 0.4995 g (1 mmol) of the above hydrazone in 50 ml of 1,2-dimethoxyethane was added 9.375 ml of 20% aqueous TiCl 3  (15 eq) [J. E. McMurry et al, JOC, Vol. 40, p. 1502 (1975)]. The biphasic mixture was refluxed for 1 hour with stirring. After cooling, 40 ml of H 2  O was added and the solution extracted with Et 2  O (1×20 ml and 4×10 ml). The ether extracts were dried over MgSO 4  and evaporated to dryness. The crude yield was 0.265 g (82.9%). The solid enone was recrystallized successively from EtOH/H 2  O and CH 2  Cl 2  /pentane and dried at room temperature/0.05 mm Hg over P 2  O 5  and paraffin, m.p. 59°-60° C. The product was identified as 1-aza-7,8,9,10,10-pentachlorotricyclo [5.2.1.0 2 .6 ] dec-4-en-3-one. This enone was formed when the enol b shown above was oxidized by MnO 2 . 
     IRν(cm -1  CHCl 3 ) 3090, 3050, 2990, 2920, 1715, 1620, 154, 1450 
     UVλ max   EtOH  220 nm (E=9320) 
       1  H NMR δ(CDCl 3  /TMS) 6.9 (d, 9 Hz, 1H), 5.8 (m, 1H), 4.1 (d, 8 Hz, 1H), 3.75 (m, 1H). 
     Anal. Calcd for C 9  H 4  NOCl 5  : C, 33.80; H, 1.25; N, 4.38. Found: C, 33.85; H, 1.79; N, 4.65. 
     0.4 g of the above enone was dissolved in 20 ml of acetone and photolyzed with a 1200 w high pressure mercury lamp at 20° C. for 12 hours. The product formed was recrystallized from aq. ethanol. M.P. 77°-78°;  1  H NMR (CDCl 3 , δTHS=0)3.5 (m, 2H), 3.88 (m,1H), 4.07 (m, 1H). The &#34;caged&#34; product was identified as 1-aza-2,3,9,10,10-pentachloropentacyclo [5.3.0.0 2 ,5.0 3 ,9.0 4 ,8 ] decan-6-one and having the structural formula: ##STR6## 
     Anal. calcd for C 9  H 4  NOCl 5  : C, 33.80; H, 1.25; N, 4.38. Found: C, 33.39; H, 1.75; N, 4.30 
     Recovery of the alcohol a is described below. The mother liquor following removal of the dinitrophenylhydrazone precipitate was treated with 2 ml of acetone to remove excess dinitrophenylhydrazino and filtered. The filtrate was stripped down under vacuum, diluted with H 2  O, neutralized with NaHCO 3  and extracted with CH 2  Cl 2 . The extracts were dried over K 2  CO 3  and stripped to yield 4.5 g of a gummy solid residue which was recrystallized 5 times from EtOH/H 2  O and dried at room temperature/0.05 mm Hg over P 2  O 5 , m.p. 99°-100° C. 
       1  H NMR δ(CDCL 3  /TMS) 6.35 (m,2H), 3.92 (m,1H), 3.78 (m, 1H), 3.65 (s, 1H exchanges in D 2  O), 3.50 (q, 1H). 
     The product was identified as 2-aza-3,3,4,5,6-pentachlorotricyclo [5.2.1.0 2 .6 ] deca-4,8,dien-10-ol having the structural formula: ##STR7## 
     Anal. Calcd for C 9  H 6  NOCl 5  : C, 33.59; H, 1.87; N, 4.35. Found: C, 33.40; H, 1.99; N, 4.09. 
     EXAMPLE 3 
     This Example illustrates the equation: ##STR8## 
     Example 2 describes the reaction between cyclopentadiene and pentachloro-α-pyrrolenine at room temperature. At low temperatures and in the presence of boron trifluoride, the cycloadduct pictured above is produced which cannot be isolated due to its instability at room temperature. It rearranges at room temperature to the cycloadduct obtained when boron trifluoride is not present. This isomeric adduct may be chlorinated, however, to produce a stable product. 
     Pentachloro-α-pyrrolenine, 5 g (21 mmole), and BF 3 . Et 2  O, 3.58 g (25 mmole), were dissolved in 15 ml of anhydrous ether and stirred for 10 minutes at room temperature. The orange solution was cooled to -80° C. and 1.38 g (21 mmole) of cyclopentadiene was added. After 8 hours the Et 2  O was blown off at -80° C. with a stream of N 2 . The gummy residue was dissolved in 15 ml of CH 2  Cl 2  containing 1.47 g of Cl 2  (28.6 mmole) and the solution was irradiated in a low temperature cell at -80° C. with a GE 300W Reflector Flood Lamp (output primarily at 590 mm). The excess Cl 2  was allowed to escape and the CH 2  Cl 2  evaporated under vacuum. The brown oil produced, 6.3 g (98.4%) was molecularly distilled at 50° C./0.03 mm Hg yielding 5.2 g (81%) of a yellow oil. The oil was decolorized with activated charcoal and dried over K 2  CO 3  in CHCl 3 . After removal of the CHCl 3  under vacuum, there remained 4.85 g (75%) of 4-aza-2,3,5,5,6,8,9-heptachlorotricyclo[5.2.1.0 2 .6 ]dec-3-ene: ##STR9## 
       1  H NMR δ(CDCl 3  --TMS) 4.25 (m, 2H), 2.90 (M. 2H), 2.60 (m, 2H) 
     IR ν(cm -1 , smear) 1710 cm -1 . 
     UV λ max   EtOH  272 nm  (4520). 
     Anal. Calcd for C 9  H 6  NCl 7  : C, 28.68; H, 1.59; N, 3.72. Found: C, 28.17; H, 1.74; N, 3.63. 
     EXAMPLE 4 
     This Example illustrates the equation: ##STR10## Only one of the two possible regioisomers was found in the product according to glpc analysis. This product was identified as 1-aza-5-phenyl-2,3,4,7,7-pentachlorobicyclo[2.2.1]-2-heptene using nmr method. 
     In a 25 ml round-bottomed flask equipped with a reflux condenser and a drying tube was placed a 4.92 g (20.5 mmole) of pentachloro-α-pyrrolenine and 2.14 g of styrene (20.5 mmole). The mixture was heated at reflux for 24 hours. The dark brown reaction mixture was decolorized once with activated charcoal, then stripped of solvent and distilled at 130° and 2 mm Hg to give 4.4 g (62%) of a yellow liquid. Upon standing in the freezer (-20° C.) for 24 hours, the clear pale yellow distillate solidified, m.p. 56°-61° C.; 
       1  H NMR (CDCl 3 , δTMS=O) 2.68 (q, 1H), 3.02 (q, 1H), 3.9 (q, 1H), J=-14, 4.6, 9.4 Hz, 7.1-7.5 (m, 5H) 
     Anal. Calcd for C 12  H 8  N Cl 5  : C, 41.92; H, 2.35; N, 4.08 Found: C, 41.78; H, 2.56; N, 3.95. 
     EXAMPLE 5 
     This Example illustrates the preparation of 1-aza-4,5-benzo-7,8,9,10,10-pentachlorotricyclo[5.2.1.0 2 .6 ]-8-decene. Only one product was found by glpc analysis in the reaction mixture. Its structure was determined by nmr method. ##STR11## 
     To a solution of indene (1.19 g, 12.5 mmol) in 20 ml of toluene was added 2.46 g (12.5 mmol) of pentachloro-α-pyrrolenine. The mixture was heated at reflux for 24 hours protected from moisture. The red brown reaction mixture was stripped of solvent to give a brown solid which, when recrystallized five times from methylene chloride, gave white crystals (1.98 g, 54%), m.p. 130°-131°: 
       1  H NMR (CDCl 3 , δTMS=O) 3.1 (m, 2H), 3.68 (m, 1H), 4.36 (d, 1H). J=8 Hz. 7.1-7.5 (m, 4H) 
     Anal. Calcd for C 13  H 8  Cl 5  N: C, 43.92; H, 2.27: N, 3.94. Found: C, 43.65; H, 2.48; N, 3.90 
     EXAMPLE 6 
     This Example illustrates the equation: ##STR12## A mixture of two regioisomers in a ratio of 2:1 resulted from this reaction: 1-aza-6-ethoxycarbonyl-2,3,4,7,7-pentachlorobicyclo[2.2.1]hept-2-ene and 1-aza-5-ethoxycarbonyl-2,3,4,7,7-pentachlorobicyclo[2.2.1]hept-2-ene. 
     In a 100 ml round-bottomed flask equipped with a reflux condenser and a drying tube was placed 15 ml of oxylene, 3.44 g of pentachloro-α-pyrrolenine (14.36 mmol) and 1.44 g (14.35 mmol) of ethyl acrylate. The mixture was heated at reflux for 48 hours at which time there was no evidence (by gas chromatography) of continuing reaction. The reaction mixture was stripped of solvent and the red-brown liquid distilled at 75° and 0.6 mm to give 1.12 g of a pale yellow liquid;  1  H NMR (CDCl 3 , δTMS=O) 3.57-3.65 (m, 1H); 2.58 (d, 2H), 1.33 (t, 3H), J=7H z ); 4.24 (q, 2H, J=7H z ). 
     Anal. Calcd for C 9  H 8  Cl 5  NO 2  : C, 31.81; H, 2.36; N, 4.12. Found: C, 31.59; H, 2.46; N, 4.07. 
     EXAMPLE 7 
     The Example illustrates the equation: ##STR13## A mixture of two regioisomers in a ratio of 2.2.1 resulted from this reaction. The major isomer was determined to be 1-aza-6-methloxycarbonyl-2,3,4,7,7-pentachlorobicyclo[2.2.1]hept-2-ene and the minor isomer 1-aza-5-methloxycarbonyl-2,3,4,7,7-pentachlorobicyclo[2.2.1]hept-2-ene by means of nmr spectroscopy. They were separated by recrystallization. 
     In a 10 ml round-bottom flask equipped with a reflux condenser and a drying tube was placed 4.92 g of pentachloro-α-pyrrolenine (20.5 mmol) and 1.76 g methyl acrylate (20.5 mmol). The mixture was heated at reflux for 48 hours at which time there was no evidence by gas chromatography of continuing reaction. The red-brown liquid was distilled at 120° C. and 0.8 mm to give a pale orange distillate which solidified upon standing at -20° C. The solid mixture was recrystallized four times from methylene chloride-pentane to yield pure 6-methoxycarbonyl isomer in the precipitate, m.p. 57°-61°, and the minor 5-methoxycarbonyl isomer in the mother liquor. 
       1  H NMR (CDCL 3 , δTMS=O) 6-methoxycarbonyl isomer: 2.47 (q, 1H); 2.62 (q, 1H); 3.51 (q, 1H), J=-13.3, 4.7, 9.3 Hz, 3.80 (s, 3H) 5-methoxycarbonyl isomer: 2.80 (q, 1H), 2.93 (q, 1H), J=-13.3, 4.0, 9.0 Hz, 3.77 (s, 3H). 
     Anal. Calcd for C 8  H 6  Cl 5  NO 2  : C, 29.49; H, 1.89; N, 4.30 Found: C, 29.16; H, 2.18; N, 4.24. 
     EXAMPLE 8 
     This Example illustrates the preparation of 1-aza-5-octyl-2,3,4,7,7-pentachlorobicyclo[2.2.1]hept-2-ene. Only one product was found by glpc analysis. ##STR14## 
     In a glass tube was placed 0.492 g (2.05 mmol) of pentachloro-α-pyrrolenine and 0.292 g of 1-decene (2.05 mmol). The tube was sealed under vacuum and heated to 140° C. for 40 hours. The dark brown liquid was distilled at 1.2 mm. and 95°-120° C. (oil bath temperature) to give a clear colorless liquid. 
     Anal. Calcd for C 14  H 20  Cl 5  N: C, 44.16; H, 5.33; N, 3.70 Found: C, 44.18; H, 5.26; N, 3.68. 
     EXAMPLE 9 
     This Example illustrates the equation: ##STR15## A mixture of two regioisomers in a ratio of 1:1 resulted from this reaction: 1-aza-6-chloromethyl-2,3,4,7,7-pentachlorobicyclo[2.2.1]hept-2-ene and 1-aza-5-chloromethyl-2,3,4,7,7-pentachlorobicyclo[2.2.1]hept-2-ene. The latter compound was isolated pure by precipitation. 
     In a 100 ml round-bottomed flask was placed 3.44 g of pentachloro-α-pyrrolenine (14.34 mmol) and 1.10 g of 3-chloropropene (14.34 mmol) in 35 ml toluene. The mixture was heated at reflux for 48 hours. The solution was evaporated and the residual brown liquid was distilled at 110° C. and 0.3 mm. The pale yellow distillate partially crystallized upon standing at 25°. The solid precipitate was shown by nmr to be the 5-chloromethyl compound, m.p. 88°-93°; 
       1  H NMR (CDCL 3 , δTMS=O) 5-chloromethyl isomer: 3.77 (m, 1H), 2.11 (q, 1H); 2.84 (q, 1H); 3.13 (m, 2H), J=-12.7, 3.3 Hz, 6-chloromethyl isomer: 1.89 (q, 1H), 2.6 (q, 1H), 3.93 (q, 1H), 3.16 (m, 2H). 
     Anal. Calcd for C 7  H 5  Cl 6  N: C, 26.62; H, 1.60; N, 4.43 Found: C, 26.56; H, 1.93; N, 4.45 
     EXAMPLE 10 
     The Example illustrates the preparation of 1-aza-5(4-chlorophenyl)-2,3,4,7,7-pentachlorobicyclo[2.2.1]hept-2-ene. Only one product was formed by glpc analysis. ##STR16## 
     In a 25 ml round-bottomed flask equipped with a reflux condenser and a drying tube was placed 4.92 g of pentachloro-α-pyrrolenine (20.5 mmol) and 2.78 g of para-chlorostyrene (20.5 mmol). The mixture was heated in an oil bath at 140° C. for 26 hours. The brown solid which formed as the reaction vessel was cooled and decolorized once with activated charcoal and recrystallized four times from methylene chloride to give white crystals. m.p. 164°-166° C.; 
       1  H NMR (CDCl 3 , δTMS=O) 2.62 (q, 1H); 3.03 (q, 1H), 3.88 (q, 1H), J=-13.4, 4.6, 9.4 Hz, 7.05-7.4 (m, 4H) 
     Anal. Calcd for C 12  H 7  Cl 6  N: C, 38.14; H, 1.87; N, 3.71. Found: C, 38.01; H, 1.88; N, 3.86. 
     EXAMPLE 11 
     This Example illustrates the preparation of 1-aza-5-ethoxy-2,3,4,7,7-pentachlorobicyclo[2.2.1]hept-2-ene. No other isomer could be isolated from the reaction product. ##STR17## 
     In a 25 ml round-bottomed flask equipped with a reflux condenser and a drying tube was placed 492 mg of pentachloro-α-pyrrolenine (2.05 mmol) and 148 mg of ethyl vinyl ether (2.05 mmol) in 5 ml of benzene. The mixture was heated at reflux for 50 hours at which time there was no evidence of continuing reaction. The light brown reaction mixture was stripped of its solvent with a rotary evaporator. The residue chromatographed on a silica gel column and eluted with chloroform-hexane giving 158 mg of a white solid, m.p. 43°-6° C. 
       1  H NMR (CDCl 3 , δTMS=O): 1.16 (t, 3H), 3.7 (m, 2H), J=7.5 Hz 2.14 (q, 1H), 2.96 (q, 1H) 4.38 (q, 1H), J=2.5, -13, 7.5 Hz 
     Anal. Calcd for C 8  H 8  Cl 5  N; C, 32.55; H, 2.72; N, 4.74. Found: C, 32.50; H, 2.54; N, 5.10 
     EXAMPLE 12 
     This Example illustrates the preparation of 1-aza-5-(4-methoxyphenyl)-2,3,4,7,7-pentachlorobicyclo[2.2.1]hept-2-ene. Only one regioisomer was found in the reaction product. ##STR18## 
     In a 25 ml round-bottomed flask equipped with a reflux condenser and a drying tube were placed 492 mg of pentachloro-α-pyrrolenine (2.05 mmol) and 275 mg of 4-vinylanisole (2.05 mmol) in 5 ml of benzene. The mixture was heated at reflux for 31 hours. The dark brown reaction mixture was stripped of solvent with a rotary evaporator and the product was distilled at 1 mm and 120° C. to give a clear pale yellow liquid which solidified after standing at -20° C. overnight. M.P. 79°-80° C.;  1  H NMR (CDCl 3 , δTMS=O) 2.60 (q, 1H), 2.99 (q, 1H), 3.80 (q, 1H). J=-13, 6.0, 11.5 Hz. 3.77 (s, 3H), 6.7-7.25 (m, 4). 
     Anal. Calcd for C 13  H 10  Cl 5  N: C, 41.77; H, 2.68; N, 3.75. Found: C, 42.07; H, 2.81; N, 3.53. 
     EXAMPLE 13 
     This Example illustrates the preparation of 1-aza-5,5-dimethyl-2,3,4,7,7-pentachlorobicyclo[2.2.1]hept-2-ene. Only one regioisomer was found in the reaction product. ##STR19## 
     A mixture of 492 mg of pentachloro-α-pyrrolenine (2.05 mmol) and 0.5 g of condensed isobutylene in a sealed thick-walled glass tube was heated at 100° C. for 72 hours. The reaction mixture was evaporated and chromatographed on silica gel eluted with chloroform-isooctane. The eluent was decolorized and evaporated to give 206 mg of a white solid, m.p. 95°-99° C.;  1  H NMR (CDCl 3  δTMS=O) 1.12 (s, 3H), 1.51 (s, 3H), 2.17 (d, 1H), 2.68 (d, 1H). J=-14 Hz. 
     Anal. Calcd for C 8  H 8  Cl 5  N: C, 32.53; H, 2.73; N, 4.74. Found: C, 32.71; H, 2.73; N, 4.67. 
     EXAMPLE 14 
     This Example illustrates the preparation of 1-aza-5-methyl-2,3,4,7,7-pentachlorobicyclo[2.2.1]hept-2-ene which was the major regioisomer found in the reaction product. ##STR20## 
     Following the procedure of Example 13 pentachloro-α-pyrrolenine and propene-1 were reacted to yield the above product, m.p. 90°-93° C.;  1  H NMR (CDCl 3 , δTMS=O) 1.11 (d, 3H, J=6.7 Hz), 1.44-2.0 (m, 1H), 2.48-3.04 (m, 2H). 
     Anal. Calcd for C 7  H 6  Cl 5  N: C, 29.88; H, 2.15; N, 4.98. Found: C, 29.64; H, 2.29; N, 4.27 
     EXAMPLE 15 
     This Example illustrates the preparation of 1-aza-5-methyl-5-phenyl-2,3,4,7,7-pentachlorobicyclo[2.1.1]hept-2-ene. Only one product was found according to glpc analysis. ##STR21## 
     A mixture of b 2.46 g (10.3 mmol) of pentachloro-α-pyrrolenine and 1.21 g (10.3 mmol) of α-methylstyrene in 20 ml of toluene was refluxed for 42 hours. The mixture was evaporated and chromatographed on silica gel with hexane to yield 341 mg of a white solid, m.p. 75°-79° C.;  1  H NMR (CDCL 3 , δTMS=O) 1.96 (s, 3H), 7.2-7.6 (m, 5H), 2.79 (d, 1H); 3.35 (d, 1H). J=-14 Hz. 
     Anal. Calcd for C 13  H 10  Cl 5  N: C, 43.72; H, 2.82; N, 3.91. Found: C, 43.71; H, 2.91; N, 3.92. 
     EXAMPLE 16 
     This Example illustrates the preparation of 1-aza-2,3,4,7,7-pentachlorobicyclo[2.2.1]hept-2-ene. ##STR22## 
     Following the procedure of Example 13 pentachloro-α-pyrrolenine and ethylene were reacted to yield a white solid, m.p. 66°-71° C.;  1  H NMR (CDCl 3 , δTMS=O), 1.954 (m, 1H), 2.474 (m, 1H), 2.192 (m, 1H), 2.617 (m, 1H). 
     Anal. Calcd for C 6  H 4  Cl 5  N: C, 26.95; H, 1.51; N, 5.25. Found: C, 26.82; H, 1.96; N, 5.10. 
     EXAMPLE 17 
     This Example illustrates the equation: ##STR23## 
     1-aza-5-methylcarbonyl-2,3,4,7,7-pentachlorobicyclo[2.2.1]-2-heptene (17). 1-aza-6-methylcarbonyl-2,3,4,7,7-pentachlorobicyclo[2.2.1]-2-heptene (17a). To 5 ml of distilled toluene contained in a 25 ml round-bottomed flask was added 0.492 g of pentachloro-α-pyrrolenine (0.00205 mol) and 0.144 g of methyl vinyl ketone (0.00205 mol). The mixture was heated at reflux for 48 hours. The dark brown reacion mixture was cooled to room temperature and stripped on a rotary evaporator. The remaining material was dissolved in 1 ml of hexane and eluted through an 11 m glass column packed with 50 g of silica gel in hexane. The eluent containing the major product (retention time 1.8 min, T c  =175°) was stripped off to give 0.0692 g (10.7%) of a white solid (17), M.P 95°-99°. The eluent containing the minor product (retention time 2.2 min, T c  =175°) was stripped off to give 0.016 g (2.5%) of an off-white solid (17a);  1  H NMR (17) δ2.47 (q, 1H), 2.47 (s, 3H), 2.80 (q, 1H), 3.72 (q, 1H). J=-13, 8.5, and 4.0H z . 
     Anal. Calcd for C 8  H 6  NCl 5  : C, 31.06; H, 1.95; N, 4.53. Found: C, 31.00; H, 1.96; N, 4.56. 
     EXAMPLE 18 
     This Example illustrates the equation: ##STR24## 
     The above regioisomer was found in the reaction mixture as the major reaction product. Minor amounts of the 5-trifluoromethyl isomer were also found. 
     1-aza-6-trifluoromethyl-2,3,4,7,7-pentachlorobicyclo[2.2.1]2-heptene. 
     To approximately 0.5 g (0.0052 mmol) of 3,3,3-trifluoropropene condensed at -78° in a heavy-walled glass tube was added 0.492 g of pentachloro-α-pyrrolenine. The tube was sealed under vacuum and heated in an oven at 165° C. for 65 hours. The tube containing the clear, dark brown reaction mixture was cooled in dry ice/acetone prior to opening, and afterwards was warmed slowly to room temperature. The remaining dark liquid was dissolved in 1 ml of hexane and eluted through an 11 mm glass column packed with 50 g of silica gel in hexane. The polarity of the eluent was increased to 3:1 hexane:chloroform until the product was collected. The eluent containing the product was filtered through a 0.45 micron millipore filter and evaporated on a rotary evaporator to give 0.058 g (8.4%) of a pale yellow liquid which solidified on standing for one hour at -20° C. 
     Anal. Calcd for C 7  H 3  NF 3  Cl 5  : C, 25.07; H, 0.90; N, 4.18. Found: C, 24.86; H, 0.93; N, 4.05. 
       1  H NMR δ2.16 (q), 2.79 (q), methylene H 
     EXAMPLE 19 
     This Example illustrates the preparation of a diaza-decachloro caged compound or dimer of pentachloro-α-pyrrolenine having the structural formula: ##STR25## 
     10 g of penachloro-α-pyrrolenine (PCP) (42 mmol) was refluxed in 100 ml of CCl 4  for five days in the presence of 1.11 g of AlCl 3  (84 mmol). The solution was extracted with water, dried, concentrated, and chromatographed on a silica gel column and eluted with pentane. 4.65 g of the starting pyrrolenine was recovered. The product (4.55 g) was eluted with acetone and decolorized with charcoal to give 4.3 g of a white solid. 
     UV (Et 2  O): end absorption; after standing at 25°: 
     λmax 282(1015), equivalent to 99.1% regeneration of pentachloro-α-pyrrolenine (PCP). 
     MW (φ 2  O freezing point depression) determination: 
     
         ______________________________________                                    
             Calcd.     Found                                             
______________________________________                                    
PCP            239.5        252.6                                         
Dimer          479          505                                           
______________________________________                                    
 
    
     mp 127°-133° (DSC, 20°/min scanning) 
     IR (CCl 4 , cm -1 , all major bands) 
     Mirex: 655, 1058, 1130, 1145 
     Dimer: 655, 1058, 1128, 1145, 1152, 1172 
     Stability: t 1/2  (25°) 9 days 
     This dimer also forms a stable complex with two equivalent of AlCl 3  in CCl 4 . 
     Characterization of AlCl 3  complex of dimer is as follows: 
     UV (CCl 4 ): 515 nm (E=3475) 
     IR (CCl 4 , cm -1 ): 
     Dimer: 655, 1058, 1128, 1145, 1152, 1172 
     Dimer-2 AlCl 3  complex: 450, 650, 660, 1160, 1128, 1145, 1155, 1200 
     Stability: Stable at 25° C. indefinitely. The favored structure of this dimer product is 1,4-diaza-2,3,3,5,6,7,8,9,10,10-decachloropentacyclo[5.3.0.0. 2 .6.0..sup.4.9.0. 5 .8 ] decane as shown. 
     Correct combustion analysis, chromatographic or spectral characterization was obtained for all compounds. Ir spectra were run on Beckman IR-12, Nmr spectra were determined with the Varian A-60 instrument, using tetramethylsilane as internal reference (δ0). Glpc analyses were performed on a Hewlett Packard 5750B chromatograph with dual flame ionization detector. All analyses were done on a 10 ft.×0.125 in. aluminum column packed with 20% SE-30 on Chromosorb W AW DMCS and at 30 cc/min of nitrogen, T 1  =270°, T D  =240°, T C  =170° (unless otherwise noted). High pressure liquid chromatography was done on Waters Associates instrument using 1 ft. μ-porasil column, 254 nm uv detector, and chloroform at 0.6 ml/ min. Melting points are uncorrected. 
     It is to be understood that all of the above structural formulas and names of products were deduced from the analytical data set forth. This is not to preclude the possibility, however, of structures other than those depicted. It is to be understood that the invention includes the compounds and reaction mixtures produced according to the methods set forth in the above Examples and described elsewhere in the specification. 
     EXAMPLE 20 
     Several of the compounds of the above examples were tested for their insecticidal activity against a variety of insects. The insects treated, the method of treatment and the solutions employed are set forth in Table 1. 
     
                       TABLE 1                                                     
______________________________________                                    
ORGANISM TEST METHOD  TEST SOLUTION**                                     
______________________________________                                    
Housefly Contact spray                                                    
                      500 ppm in acetone                                  
German   Contact spray                                                    
                      500 ppm in acetone                                  
cockroach                                                                 
American Contact spray                                                    
                      500 ppm in acetone                                  
cockroach                                                                 
Alfalfa  Contact spray                                                    
                      500 ppm in acetone                                  
weevil                                                                    
Cotton aphid                                                              
         Leaf dip*    40 ppm - acetone + adjuvant                         
                      dispersed in water                                  
2-Spot Mite                                                               
         Leaf Dip*    40 ppm - acetone + adjuvant                         
                      dispersed in water                                  
Mite eggs                                                                 
         Leaf dip*    40 ppm - acetone + adjuvant                         
                      dispersed in water                                  
Cabbage  Leaf dip     500 ppm - acetone + adjuvant                        
looper                dispersed in water                                  
Mock     Leaf dip     500 ppm - acetone + adjuvant                        
colorado              dispersed in water                                  
potato                                                                    
beetle                                                                    
Tobacco  Leaf dip     500 ppm - acetone + adjuvant                        
budworm               dispersed in water                                  
Housefly Soil mix     2400 ppm - acetone + adju-                          
larvae                vant dispersed in water                             
Aphid    Soil drench  80 ppm - acetone + adju-                            
                      vant dispersed in water                             
Aphid    Foliage spray                                                    
                      2000 ppm - acetone + adju-                          
         Potted plant vant dispersed in water                             
Alfalfa  Foliage spray                                                    
                      2000 ppm - acetone + adju-                          
weevil   Potted plant vant dispersed in water                             
Housefly Cardboard    18.75 mg/6 ml - kerosene:                           
         surface spray                                                    
                      acetone 1:1                                         
Argentine ant                                                             
         Cardboard    6 mg/6 ml - kerosene:                               
         surface spray                                                    
                      acetone 1:1                                         
______________________________________                                    
 *Infested prior to dip                                                   
 **Screen dose given, continued with serial dilutions when active         
 
    
     The results of the test are set forth in Table 2. 
     
                                           TABLE 2                                 
__________________________________________________________________________
                                                     Parathion-           
                                    Hock         Cotton                   
                                                     resistant            
                                    Colorado                              
                                         7-Day Ex-                        
                                                 Aphid                    
                                                     Two-spotted          
Com-                                Potato                                
                                         posure  Adult                    
                                                     Spider Mite          
pound                                                                     
    Alfalfa                                                               
        House-                                                            
             American                                                     
                   German                                                 
                         Tobacco                                          
                               Cabbage                                    
                                    Beetle                                
                                         Housefly                         
                                                 Leaf Dip                 
Ex- Weevil                                                                
        fly  Cockroach                                                    
                   Cockroach                                              
                         Budworm                                          
                               Looper                                     
                                    2nd Stg.                              
                                         Larvae                           
                                                  ##STR26##               
ample                                                                     
    Adult                                                                 
        Adult                                                             
             Nymph Adults                                                 
                         Larvae                                           
                               Larvae                                     
                                    Larva                                 
                                         Treatment                        
                                                 or %                     
                                                      ##STR27##           
Num-                                                                      
    Contact Spray        Leaf Feed                                        
                                          ##STR28##                       
                                                 C @ Control @ ppm*       
ber                                                                       
     ##STR29##                                                            
                          ##STR30##      @ ppm*  ppm*                     
                                                     Egg  Adult           
__________________________________________________________________________
Ex. 3                                                                     
     ##STR31##                                                            
        83@100                                                            
              ##STR32##                                                   
                   45@500                                                 
                          ##STR33##                                       
                               26@500                                     
                                     ##STR34##                            
                                          ##STR35##                       
                                             67@40                        
                                                 NA  31@40                
                                                          NA              
Ex. 4                                                                     
    NA  10@100                                                            
             NA    NA    66@500                                           
                               NA   50@500                                
                                         43@40                            
                                             NA  NA  77@40                
                                                          NA              
Ex. 7                                                                     
    NA  26@100                                                            
             NA    NA    13@500                                           
                               NA   NA   13@40                            
                                             NA  36@10                    
                                                     NA   NA              
Ex. 5                                                                     
    NA  42@100                                                            
             NA    NA     6@500                                           
                               NA   NA   47@40                            
                                             NA  NA  13@40                
                                                          NA              
Ex. 19                                                                    
    NA  73@100                                                            
             15@250                                                       
                   NA    NA    NA   NA   47@40                            
                                             NA                           
                                                  ##STR36##               
                                                     21@40                
                                                          NA              
Std.                                                                      
    Methyl                                                                
        Dibron                                                            
             Diazinon                                                     
                   Diazinon                                               
                         Methyl                                           
                               Methyl                                     
                                    Methoxy-                              
                                         Diazinon                         
                                                 Dibron                   
                                                     Tedion               
                                                          Dibron          
Para-                                                                     
         ##STR37##                                                        
              ##STR38##                                                   
                    ##STR39##                                             
                         Para- Para-                                      
                                    chlor                                 
                                          ##STR40##                       
                                             37@40                        
                                                  ##STR41##               
                                                      ##STR42##           
                                                           ##STR43##      
thion                    thion thion                                      
                                     ##STR44##                            
 ##STR45##                                                                
                          ##STR46##                                       
                                ##STR47##                                 
                                    Methyl-                               
                                    para-                                 
                                    thion                                 
                                     ##STR48##                            
__________________________________________________________________________
 *LD.sub.90 values underlined; % control not underlined                   
 NA  not active