Patent Publication Number: US-2022211927-A1

Title: Method for trendng automated peritoneal dialysis treatments

Description:
PRIORITY CLAIM 
     This application claims priority to and the benefit as a continuation application of U.S. patent application Ser. No. 16/921,478, entitled “Method and Apparatus for Trending Automated Peritoneal Dialysis Treatments”, filed Jul. 6, 2020, which claims priority to and the benefit as a continuation application of U.S. patent application Ser. No. 15/945,391, entitled, “Drain and Fill Logic for Automated Peritoneal Dialysis”, filed Apr. 4, 2018, now U.S. Pat. No. 10,702,645, which claims priority to and the benefit as a continuation application of U.S. patent application Ser. No. 14/854,923, entitled, “Drain and Fill Logic for Automated Peritoneal Dialysis”, filed Sep. 15, 2015, now U.S. Pat. No. 9,943,632, which claims priority to and the benefit as a continuation application of U.S. patent application Ser. No. 13/458,625, entitled, “Drain and Fill Logic for Automated Peritoneal Dialysis”, filed Apr. 27, 2012, now U.S. Pat. No. 9,132,222, which claims priority to and the benefit as a continuation application of U.S. patent application Ser. No. 12/362,259, entitled, “Drain and Fill Logic for Automated Peritoneal Dialysis”, filed Jan. 29, 2009, now U.S. Pat. No. 8,182,673, the entire contents of each of which are incorporated herein by reference and relied upon. U.S. patent application Ser. No. 14/854,923 is also a continuation of U.S. patent application Ser. No. 13/402,355, entitled, “Method for Optimizing Tidal Therapies Employing Ultrafiltrate Trending”, filed Feb. 22, 2012, now U.S. Pat. No. 9,433,719, which claims priority to and the benefit as a continuation application of U.S. patent application Ser. No. 12/362,240, entitled, “Method for Optimizing Tidal Therapies Employing Ultrafiltrate Trending”, filed Jan. 29, 2009, now U.S. Pat. No. 8,142,649, the entire contents of each of which are incorporated herein by reference and relied upon. 
    
    
     BACKGROUND 
     The present disclosure relates generally to peritoneal dialysis, and in particular to peritoneal dialysis systems useful in manipulating the number of cycles, drain volumes and fill volumes in a multi-cycle dialysis therapy. The calculations and manipulations are useful in assuring use of all or nearly all a prescribed dialysis solution volume in treating a particular patient during a particular therapy. 
     Automated Peritoneal Dialysis (“APD”) is a natural evolution of Continuous Ambulatory Peritoneal Dialysis (“CAPD”), in which the patient introduces the entire contents of a dialysate solution bag into his/her peritoneum and allows the volume to dwell for three to six hours. After the dwell period, the fluid is drained using gravity. The above process is typically repeated three or four times each day as necessary. Working adults may perform an exchange at home before leaving for work, one at work during their lunch hour, one when the patient arrives home from work and one just before the patient goes to bed. Some school-aged patients follow a similar routine except that they perform their mid-day exchange at school. 
     APD machines (sometimes called “cyclers”) perform sequential exchanges during the night when the patient is sleeping, making APD a more convenient therapy. Also, the treatment is carried out in the privacy of the patient&#39;s home, so that others do not have to know that the patient is on dialysis. It is no surprise that most patients would prefer APD over CAPD. 
     However, there are some important differences between CAPD and APD. CAPD is typically performed with the patient sitting upright in a chair, whereas APD is performed with the patient lying down. The patient&#39;s internal catheter may work its way down into the bottom of the patient&#39;s peritoneal cavity (pelvic area) during the day when the patient is ambulatory so that it is not in an optimum position for draining when the patient is in a prone or sleeping position. Even with the catheter in the correct position, a supine or sitting position is generally better for draining than is the prone or sleeping position. Thus APD treatments can experience incomplete drains. 
     Continuous Cycling Peritoneal Dialysis (“CCPD”) is one popular APD therapy because it performs a full drain after every dwell, minimizing the potential for overfill due to the fluid that is ultrafiltered from the patient&#39;s body. CCPD can however present a challenge when a patient does not drain well. In a night therapy, the patient cannot be awakened every 1.5 hours, so that the patient can sit up and ensure a complete drain. 
     Accordingly, APD cyclers in some instances advance from drain to fill after a minimum percentage of the patient&#39;s previous fill volume has been drained, for example, when the drain flow rate has slowed down to a point that time is being wasted that could be used for therapeutic benefit. Alarms will typically be posted if the drain flow rate slows to a certain rate before the minimum drain percentage has been exceeded. The HomeChoice/Pro® APD cycler, provided by the assignee of the present disclosure, is considered one of the best draining cyclers on the market, producing fewer alarms when compared to its competitors. Even still, low drain volume alarms occur relatively frequently. 
     An APD cycler with improved drain control is needed accordingly. 
     SUMMARY 
     As discussed above, automated Peritoneal Dialysis (“APD”) cyclers perform sequential exchanges during the night making APD a convenient dialysis therapy. An alternative PD therapy, continuous ambulatory peritoneal dialysis (“CAPD”) is performed during the day, making CAPD more life intrusive. During CAPD, however, the patient is awake and can move around and sit up during drains, allowing drains to be performed completely. 
     At night, when the patient is performing APD, the patient is lying down. The patient&#39;s internal catheter may have shifted during the day, making the patient susceptible to an incomplete drain. The APD system of the present disclosure is programmed to advance to a fill if a drain flow rate slows to a certain point and a minimum drain volume has been achieved. If the drain has not reached this minimum volume, which is often based upon a certain percentage of the programmed fill, the system will alarm. When an alarm occurs, the patient is awakened, which is not desirable. The system of the present disclosure greatly reduces the number of low drain alarms. 
     Another therapy concern enhancing the low drain problem is a limit placed on how full the patient can be filled. Multiple incomplete drains leave an ever increasing residual volume of fluid in the patient. If the residual volume increases to a certain point, the next fill may push the patient&#39;s intra-peritoneal volume (“IPV”) past an allowable limit. The subsequent fill may therefore be shorted to prevent overfilling, but this may cause the treatment not to use all of the fluid for treatment. 
     To remedy the above, in one primary embodiment, the system begins a CCPD treatment that attempts to drain the patient completely after each drain. When performed properly, the CCPD therapy is quite effective. The patient&#39;s initial drain (at night, just before bed) and final drain (in the morning, after waking) should be relatively if not totally complete because the patient can sit-up and move around to help move the patient&#39;s catheter into areas of his/her peritoneum that are pocketing fluid. 
     It is the intermediate drains that may be difficult to complete especially considering that the therapy needs to move along and cannot wait while a low drain flow rate occurs while attempting to drain the patient completely. When the low flow rate is sensed, the system determines that it is time to move to the next fill. If the previous drain was almost complete, e.g., 85% of prescribed, the system in one embodiment continues to provide the prescribed CCPD therapy. If all subsequent drains are complete, the final drain can remove the additional, e.g., 15%, fluid from the delinquent drain. 
     If multiple “almost complete” drains occur, the patient can begin to build a substantial residual volume due to the cumulative effects of the incomplete drains. If the system determines that a next fill will increase the patient&#39;s intra-peritoneal volume (“IPV”) past an allowable volume, e.g., 1.9 times the prescribed fill volume, the system switches to a tidal therapy that reduces the prescribed drain to a tidal volume, increasing the likelihood of the system having a subsequent successful drain. The tidal therapy also reduces succeeding fills, such that the patient&#39;s IPV does not exceed the allowable limit. 
     The now tidal therapy may add one or more cycle if needed to use all of the prescribed fresh solution. A logic flow diagram is shown below with various equations for determining when the one or more additional cycle is needed. Whether or not a cycle is added, the system divides the remaining unused therapy fluid and the remaining therapy time evenly over the number of remaining cycles. 
     The switch to tidal therapy attempts to reduce low drain alarms that occur if the actual drain does not meet a threshold percentage, e.g., 85%, of the prescribed drain. The tidal therapy allows a larger residual volume to reside within the patient at the end of a drain, increasing the likelihood that a flow rate at the end of the drain will be high and that the drain will not be ended early due to a low drain flow rate. The tidal therapy uses all of the remaining fresh dialysate, so that the patient is not deprived of any therapeutic benefit. The tidal therapy is also completed on time and ensures that the patient is not overfilled with dialysis fluid at any time. 
     In one embodiment, a dialysis system is provided, the dialysis system including at least one dialysis fluid pump configured to pump a dialysis fluid to and from a patient during the therapy, the dialysis system also including a logic implementer configured to control the dialysis fluid pumped by the at least one dialysis fluid pump to and from the patient during the therapy, the logic implementer also configured to calculate cumulative ultrafiltration and to reduce a prescribed fill volume if an amount of a prior incomplete drain causes the cumulative ultrafiltration at an end of the prior drain to exceed a negative ultrafiltration limit. 
     In another embodiment, a dialysis system is provided, the dialysis system including at least one dialysis fluid pump configured to pump a dialysis fluid to and from a patient during a multi-cycle dialysis therapy, the dialysis system also including a logic implementer configured to control the at least one dialysis fluid pump, the logic implementer also configured to calculate cumulative drain volume and cumulative fill volume to determine a number of remaining cycles by dividing a total remaining therapy volume by a calculated fill volume, wherein the calculated fill volume is higher or lower than a prescribed fill volume, in order to use substantially all a prescribed therapy volume. 
     In yet another embodiment, a dialysis system is provided, the dialysis system including at least one dialysis fluid pump configured to pump a dialysis fluid to and from a patient during a multi-cycle dialysis therapy, the dialysis system also including a logic implementer configured to control the at least one dialysis fluid pump during the therapy, the logic implementer also configured to calculate cumulative drain volume and cumulative fill volume to determine a number of remaining cycles by (i) adding one plus (a total remaining therapy volume divided by a prescribed fill volume) if a prior drain was a complete drain or (ii) dividing the total remaining therapy volume by (the prescribed fill volume multiplied by a prescribed tidal percent) if the prior drain was not a complete drain, and if a cycle is added, to calculate a new fill volume by dividing the total remaining therapy volume by the number of remaining cycles. 
     In another embodiment, a tidal therapy is provided in which a predicted amount of patient UF for each cycle is obtained from a trend of UF values for the patient, for the tidal therapy, and for a particular dialysate, having a particular osmotic agent or dextrose level. In this manner, UF can be predicted very accurately. 
     Knowing predicted UF accurately allows the system to predict the patient&#39;s intraperitoneal volume or IPV very accurately. For example, assuming that the patient&#39;s initial drain is a successful complete drain (patient awake), the patient is then filled to a known level. The subsequent dwell will remove an amount of UF from the patient that should closely approximate the predicted removal of UF. Thus the actual IPV at the end of the dwell should closely approach the actual fill amount (which is known) plus a predicted UF removed (which is based on trended UF). 
     The UF trend is stored and updated in one embodiment at the cycler or automated peritoneal dialysis (“APD”) machine. The patient can recall the trend at any time to view same including historical trending data. The APD machine can be linked via a data network, such as an internet, so that a dialysis clinician or doctor can also view the patient&#39;s UF trend remotely. In an alternative embodiment, the UF trend is stored and updated on a remote server, which the patient can access via the data network. 
     The UF trend in one embodiment plots patient single day UF data. If the patient removes 2000 ml of UF on day X, 2000 ml is recorded for day X. And the daily UF in one embodiment is the UF removed over the nightly treatment, that is, the UF removed after the initial drain (from previous days last fill or from day exchange) and prior to the last fill, if provided. Here, the daily UF is that removed over the course of multiple tidal dwells. This total UF can be measured accurately because the patient is drained completely on the initial drain. The measured UF, which is entered into the trend is then the total amount of drained fluid, not including the initial drain, but including the last drain, which is typically a complete drain with the patient awake, less the total amount of fresh dialysis fluid pumped to the patient, but not including the final fill. The APD machine can measure each of these values accurately to provide a true UF data point. 
     In an alternative embodiment, the trended UF data is averaged UF data for a particular therapy using a particular dialysate glucose level. The average can for example be a rolling seven or thirty day average that averages the last seven or thirty day&#39;s UF entries, respectively, for each dialysate glucose solution used by the patient, to form a rolling average UF volume for such glucose level solution. Such averaging tends to smooth UF anomalies for treatments that may have undergone unusual events, such as alarms or other stoppage. 
     In view of the above embodiments, it is accordingly an advantage of the present disclosure to provide improved Continuous Cycling Peritoneal Dialysis (“CCPD”) and tidal automated peritoneal dialysis (“APD”) therapies. 
     Another advantage of the system of the present disclosure is to provide an APD therapy that tends to limit low drain alarms. 
     A further advantage of the system of the present disclosure is to provide an APD therapy that tends to limit patient overfilling. 
     Yet another advantage of the system of the present disclosure is to provide an APD therapy that tends use all available fresh dialysis fluid over the course of treatment. 
     A further advantage of the system of the present disclosure is to provide an APD therapy that adjusts to an incomplete drain to prevent a patient overfill. 
     Still another advantage of the system of the present disclosure is to provide an APD therapy that reacts to an incomplete drain to ensure that all available treatment fluid is used over the course of treatment. 
     Still a further advantage of the system of the present disclosure is to provide an APD therapy that employs ultrafiltration (“UF”) trending to provide trending data that allows for accurate prediction of UF and overall intra-peritoneal volume (“IPV”). 
     Additional features and advantages are described herein, and will be apparent from the following Detailed Description and the figures. 
    
    
     
       BRIEF DESCRIPTION OF THE FIGURES 
         FIG. 1  is a perspective view of one embodiment of a dialysis system having a drain and fill sequence according to the present disclosure. 
         FIG. 2  is a perspective view of one embodiment of a disposable cassette operable with the dialysis system having a drain and fill sequence according to the present disclosure. 
         FIG. 3  is an intra-peritoneal volume (“IPV”) versus time graph showing an example therapy in which a continuous cycling peritoneal dialysis (“CCPD”) treatment is performed according to a prescribed therapy. 
         FIG. 4  is an IPV versus time graph showing an example therapy in which a continuous cycling peritoneal dialysis (“CCPD”) treatment uses a total volume of dialysis fluid but accumulates a large IPV due to incomplete drains. 
         FIG. 5  is an IPV versus time graph showing an example therapy in which a continuous cycling peritoneal dialysis (“CCPD”) treatment accumulates less IPV than the treatment of  FIG. 4  but does not use a total volume of dialysis fluid. 
         FIGS. 6A-6C  are IPV versus time graphs showing two example therapy performed according to the principles of the present disclosure. 
         FIGS. 7A-7E  are IPV versus time graphs showing additional example therapies performed according to the principles of the present disclosure. 
         FIG. 8  is a chart showing percentages of when low drain alarms occur relative to how much fluid has been drained from the patient when the alarm occurs. 
         FIGS. 9 and 10  is an IPV versus time graph showing other example therapies performed after an occasion when a previous fill uses less than, more than, respectively, a prescribed amount of fresh dialysate. 
         FIGS. 11A-11C  are logic flow diagrams illustrating embodiments of methods performed by the system of the present disclosure. 
         FIG. 12  is one example of a trend of UF removed from a patient over a number of treatment days, and for different dextrose level dialysates used, the trend used in combination with a tidal PD therapy. 
         FIGS. 13 to 16  are IPV versus time graphs showing various examples of a tidal therapy performed using patient trended UF data. 
         FIG. 17  is another example of a rolling average trend of UF removed from a patient over a number of treatment days. 
         FIG. 18  is an IPV versus time graph showing one example of a tidal therapy performed using patient trended UF data, and in which UF is removed gradually from the patient over a dwell to limit the IPV. 
     
    
    
     DETAILED DESCRIPTION 
     Dialysis System Generally 
     Referring now to the drawings and in particular to  FIGS. 1 to 2 , a renal failure therapy system  10  is provided. System  10  is applicable generally to any type of automated peritoneal dialysis (“APD”) system. System  10  in the illustrated embodiment includes a dialysis instrument  12 . Dialysis instrument  12  is configured for the type of APD therapy system provided. Dialysis instrument  12  includes a central processing unit (“CPU”) and memory, and may include one or more additional processor and memory (e.g., safety, valve, heater, pump, video and audio (e.g., voice guidance) controllers) operable with the CPU, the totality of which may be called a logic implementer. The logic implementer operates with a user interface (“UI”) such as a graphical user-machine interface (“GUI”), e.g., via a video controller component of the logic implementer. The GUI includes a video monitor  20  and one or more types of input devices  22 , such as a touch screen or electromechanical input device (e.g., a membrane switch). 
     The logic implementer in cooperation with video monitor  20  provides therapy instructions and setup confirmation to the patient or caregiver visually via characters/graphics. For example, characters/graphics can be displayed to (i) provide instructions regarding placement of a distal end of the patient line onto instrument  12  (discussed below) for priming and/or (ii) inform the patient when the patient line has been primed fully. Additionally or alternatively, a voice guidance controller of the logic implementer in cooperation with speakers  24  provides (i) and/or (ii) listed above. 
     As seen in  FIG. 1 , dialysis instrument  12  accepts and operates with a disposable set  30 . Disposable set  30  includes one or more supply bag  32   a  to  32   c  (referred to herein collectively as supply bags  32  or individually, generally as supply bag  32 ), shown here as dual-chamber supply bags separating two fluids via a peel or frangible seal  34 . Disposable set  30  also includes a drain bag (not illustrated), a warmer bag  36 , and patient tubes  38   a  to  38   d , respectively (referred to herein collectively as tubing or tubes  38  or individually, generally as tube  38 ) and a disposable pumping/valve cassette  50  ( FIG. 2 ). 
     Warmer bag  36  is used in a batch heating operation in which the top of instrument  12  batch heats fluid within bag  36 . System  10  can also pump spent fluid to a house drain, such as a bathtub, a toilet or sink, instead of to a drain bag, in which case the drain bag is not needed. 
     While three supply bags  32  are shown, system  10  can employ any suitable number of supply bags. Supply bags  32  are shown having multiple chambers  42   a  and  42   b , separated by frangible seal  34 , which hold different solutions depending on the type of therapy employed. For example, chambers  42   a  and  42   b  can hold buffer and glucose for an overall PD dialysate having a desired glucose level. Supply bags  32  are alternatively single chamber bags, which hold a single premixed solution, such as premixed PD dialysate having a desired glucose level. 
     As seen in  FIGS. 1 and 2 , a disposable cassette  50  connects to supply bags  32 , drain bag and warmer bag  36  via tubes  38   a ,  38   b  and  38   c , respectively. Tube  38   d  runs from cassette  50  to a patient connection  44 . Cassette  50  in one embodiment includes a rigid structure having rigid outer walls  52  and a middle, base wall (not shown) from which pump chambers ( 60   a  and  60   b  as shown in  FIG. 2 ), valve chambers (e.g., volcano valve chambers) and rigid fluid pathways extend. Rigid fluid ports  56  extend from a side wall  52  and communicate fluidly with the rigid cassette pathways and connect sealingly to tubing  38 . Tubing  38  can be fixed to ports  56 , in which case the bags  32  are spiked to allow fluid from the bags to flow through tubing  38  into cassette  50 . Alternatively, tubing  38  is fixed to bags  32 , in which case ports  56  are spiked to allow fluid from the bags  32  and tubing  38  into cassette  50 . 
     A pair of flexible membranes or sheets  58  (only one shown) is sealed to outer rigid walls  52  of the cassette. Cassette  50  is sealed within instrument  12  such that sheeting  58  forms the outer surfaces of the rigid fluid pathways of the cassette. One of the sheets is moved to pump fluid through pump chambers ( 60   a  and  60   b ) and to open and close the cassette valves. 
     Instrument  12  can actuate the pump and valve chambers of cassette  50  pneumatically, mechanically or both. The illustrated embodiment uses pneumatic actuation. The HomeChoice® APD system uses a pneumatic system described in U.S. Pat. No. 5,350,357 (“the &#39;357 patent”), the entire contents of which are incorporated herein by reference. As seen in  FIG. 2 , instrument  12  includes a flexible membrane  14 , which creates different sealed areas with cassette sheeting  58  at each of the pump and valve chambers of cassette  50 . Membrane  14  moves with the sheeting  58  in those areas to either open/close a valve chamber or pump fluid through (into and out of) a pump chamber. An interface plate (not shown) is located behind membrane  14  and includes first and second chamber halves (not shown) that mate with chamber halves  60   a  and  60   b  of cassette  50  to form a pair of fixed volume pump chambers. 
     Instrument  12  in the illustrated embodiment includes a door  16 , which closes against cassette  50 . Door  16  includes a press plate  18 , which can be operated mechanically (e.g., via the closing of the door) and/or pneumatically (e.g., via an inflatable bladder located in the door behind the press plate). Pressing plate  18  against cassette  50  in turn presses cassette  50  against pumping membrane  14 , which cooperates with sheeting  58  of cassette  50  to pump fluid through chambers  60   a  and  60   b  and to open and close the cassette valve chambers. 
     The cassette interface plate is located behind membrane  14 . Cassette interface plate is configured to apply positive or negative pressure to the cooperating membrane  14  and cassette sheeting  58  at the different valve and pump areas. For example, positive pressure is applied to membrane  14 /sheeting  58  at areas of the membrane/sheeting located within the internal walls of cassette  50  that define pump chambers  60   a  and  60   b  to push fluid out of the pump chambers and within the chamber halves of the interface plate (not shown). Negative pressure is applied to membrane  14 /sheeting  58  at those same areas to pull fluid into the pump chambers. Likewise, positive pressure is applied to membrane  14 /sheeting  58  at areas of the sheeting within the internal walls of cassette  50  and the interface plate defining the valve chambers to close outlet ports of the valve chambers. Negative pressure is applied to membrane  14 /sheeting  58  at those same areas to open the outlets of the valve chambers. 
     U.S. Pat. No. 6,814,547 (“the &#39;547 patent”) assigned to the assignee of the present disclosure, discloses a pumping mechanism in connection with  FIGS. 17A and 17B  and associated written description, incorporated herein by reference, which uses a combination of pneumatic and mechanical actuation. FIGS. 15, 16A and 16B of the &#39;547 patent and associated written description, incorporated herein by reference, teach the use of mechanically actuated valves. One or both of these mechanisms can be used instead of the purely pneumatic system of the HomeChoice® machine. 
     The &#39;357 patent and the &#39;547 patent also teach different systems and methods, incorporated herein expressly by reference, of knowing and controlling the amount of fresh dialysate delivered to the patient, the amount of effluent dialysate removed from the patient, and thus the amount of additional fluid or ultrafiltrate (“UF”) removed from the patient. UF is the blood water that the patient accumulates between treatments due to the patient&#39;s failed kidneys. The dialysis treatment removes this blood water as UF in an attempt to bring the patient back to his or her dry weight. Either of the systems and method of the &#39;357 patent and the &#39;547 patent can be used as described below for controlling the fill and drain volumes according to the methods of system  10 . 
     Drain and Fill Logic for Automated Peritoneal Dialysis 
     Referring now to  FIG. 3 , one example plot of the intra-peritoneal patient volume (“IPV”) versus time over an ideal CCPD for system  10  is illustrated. Here, each drain empties completely the fluid from the patient&#39;s peritoneum, including the previous fill volume plus any UF that has occurred during the previous dwell period. As seen in  FIG. 3 , therapy starts with an initial drain to empty, followed by a number of identical cycles consisting of a fill to a prescribed volume, a dwell of a prescribed duration, and a drain that removes the original fill volume plus all of the UF that has been absorbed from the patient.  FIG. 3  illustrates a five cycle therapy having a 2000 ml fill volume and 150 ml/cycle UF volume. The initial drain recovers all of the fluid from the previous day&#39;s last fill that has remained in the patient&#39;s peritoneal cavity throughout the day. 
     Patients sometimes pocket fluid so that a drain that is supposed to be to empty does not remove all of the previous fill volume. System  10  in one embodiment sets a minimum drain percentage that must be obtained when the fluid flow slows or stops. If the minimum drain volume is not met, system  10  posts a low drain volume alarm. In such a case, the therapy does not advance to fill, that is, if the drain volume is not equal to or greater than the minimum drain percentage. In  FIG. 3 , system  10  fills the patient to the prescribed fill volume in each fill because the minimum drain percentage for each drain has been met. One example minimum drain percentage for system  10  is about 85% of the fill volume. 
     System  10  in one embodiment calculates the amount of UF obtained at the end of the drain phase of each cycle as follows: 
       UF=sum of the volumes drained−sum of the volumes filled
 
     The initial drain and last fills are not included in the UF calculation. Calculated UF will be positive as long as more spent fluid drained than fresh dialysis fluid filled. A zero UF value means that the volume drained after any number of cycles is equal to the volume filled during those cycles. A drain that does not recover all of the fluid that was delivered to the patient during the previous fill results in a negative UF determination. Unless the patient is absorbing fluid, a negative UF implies that the patient&#39;s intra-peritoneal volume is in excess of a prescribed fill volume. 
     It is normal for the intra-peritoneal volume to exceed the prescribed fill volume. The intra-peritoneal volume during a CCPD dwell phase consists of the following volumes: intra-peritoneal volume (“IPV”)=prescribed fill volume+residual volume at end of a previous drain+UF from dwell. It is also not unusual for the residual volume in the patient&#39;s peritoneum to equal 5 to 10% of the prescribed fill volume at the end of a drain cycle. 
     The UF that has accumulated during a dwell will depend upon the osmotic gradient (a function of the dextrose level of the dialysate), the time in dwell and the transport characteristics of the patient&#39;s peritoneum. UF can range from zero to 25% of the prescribed fill volume. Thus, it is not unusual for the intra-peritoneal volume reach about 130% of the prescribed fill volume. In practice, it is expected that the IPV will vary between 100 and 130% of the prescribed fill volume. 
     When the residual volume at the end of drain increases, e.g., to more than five or ten percent of the prescribed fill volume, the patient&#39;s intra-peritoneal volume increases accordingly during the next fill and dwell. If system  10  sets an 85% minimum drain percentage limit, the increase in residual volume is limited to 15% per cycle plus the actual UF obtained during the cycle. Successive fill cycles after successive drains just meeting the 85% minimum drain percentage requirement will cause the patient&#39;s intra-peritoneal volume to increase at each successive cycle. System  10  also tracks cumulative UF and places a limit on the maximum negative UF value allowed. If this value is exceeded at any time during a therapy, system  10  will not advance from drain phase to the next fill phase even if the minimum drain percentage has been met when the drain ends. System  10  in one embodiment allows the patient or caregiver, in certain instances, to override the negative UF alarm and allow the therapy to advance to the next fill. 
       FIG. 4  illustrates a therapy in which successive drains just meet the minimum 85% drain volume and system  10  advances the therapy in each case to the next full fill. System  10  allows the intra-peritoneal volume to increase past the 130% of prescribed fill volume limit (2600 ml, after third fill), through the 160% of prescribed fill volume limit (3200 ml, after fourth fill) and into the 190% of prescribed fill volume limit (3800 ml, after fifth fill). The actual UF per cycle in the therapy of  FIG. 4  is 150 ml per cycle which equals 7.5% of the 2000 ml fill volume. 
     System  10  in  FIG. 4  posts a negative UF alarm when drain 4 ends with the minimum drain percentage just met because the cumulative negative UF has reached its limit, e.g., 1200 ml (four drains×15% of 2000 ml). The patient or caregiver in the illustrated example elects to bypass the negative UF alarm, so that system  10  advances to the fifth full fill, in which case the patient&#39;s intra-peritoneal volume exceeds a 190% of the fill volume limit (1.9×2000=3800 ml). 
     The therapy illustrated by  FIG. 4  fills the patient with 2000 ml of fluid during each of the night fills using all 10,000 ml of solution available for use during therapy. However, during this therapy, the patient&#39;s IPV reaches 3950 ml, which is 197.5% of the prescribed fill volume. Furthermore, the patient encounters and has to address an alarm (negative UF) that interrupts his/her sleep. 
       FIG. 5  illustrates an embodiment in which the patient volume stays below 190% of the prescribed fill volume. The patient does not encounter any alarms during the night. As seen, the therapy of  FIG. 5  encounters the same drain issues as the therapy illustrated in  FIG. 2 . Drains 1 through 4 each end with only 85% of the preceding fill volume recovered. Cumulative negative UF increases in 15% steps to 45% at the end of drain 3. 
     System  10  in the example of  FIG. 4  places a 40% limit on negative UF (as opposed to 60% (=1200/2000 in  FIG. 4 ), so that system  10  causes Fill  4  to be shorted by 5%, limiting the negative UF at 40%. System  10  shorts Fill  5  by 15% because Drain 4 was also 15% short. The maximum value for the IPV is 3550 ml (177.5% of prescribed fill volume) during this therapy. The 40% negative UF limit could have been set to a lower value, such as 30%, limiting the maximum IPV to 3250 ml. 
     The therapy illustrated in  FIG. 5  prevented the IPV from exceeding 190% of the prescribed fill volume but did allow the IPV to exceed 160% of the prescribed fill volume. The therapy of  FIG. 5  used only 9,600 ml of the 10,000 ml of dialysis fluid that was available. Assuming the fluid could have been used to its maximum potential, the therapy illustrated in  FIG. 5  was 96% effective in delivering the maximum possible therapeutic benefit. The therapies illustrated in  FIGS. 3 and 4 , on the other hand, were 100% effective. 
     The therapies illustrated in  FIGS. 4 and 5  are considered to be CCPD therapies because all drains are prescribed to go to empty. The only drains that actually made it to empty, however, were the initial drain and the last drain in which the patient was awake and could move around, or sit up, to drain fully. The CCPD therapies are accordingly pseudo-tidal in nature. If they had been programmed as tidal therapies with a tidal percent of 85%, all of the drains in  FIGS. 4 and 5  would have ended when 85% of the programmed fill volume plus expected UF had been drained. The following fills would have brought the patient volume back to 100% of the programmed fill volume. 
       FIGS. 6A-6C  and  FIGS. 7A-7E  demonstrate of a method of one embodiment, with respectively, 75% and 65% tidal volumes, rather than the 85% discussed above with respect to  FIG. 5 . In  FIGS. 6A-6C , the operation of a 75% tidal system is depicted, each with an additional cycle as compared to  FIG. 5 . In  FIG. 6A , the system operates as intended, and in this case, an “ideal” patient responds as intended. In  FIG. 6A , 2000 ml is used for the first, 100% fill, and all drains except the first and the last are about 1698 ml. This represents 75% of a 2105 ml fill volume and a calculated 120 ml UF. Note that 6 cycles with 120 ml of UF would remove a total of about 720 ml ultrafiltrate over the duration of the nocturnal therapy. The patient volume does not appear to reach even 2200 ml, i.e., does not even reach 10% over the initial patient volume (IPV). As seen in  FIG. 6A , each cycle lasts about 1.5 hours and there are a total of six cycles, for a 9-hour therapy, from about 10:30 pm to about 7:30 the next morning. 
     In  FIG. 6B , the same 2105 ml fill volume is used, but in this case, the patient does not drain as expected. The same drain volume, about 1698 ml, is expected, but does not occur in every drain cycle. In the first drain cycle, only about 1450 ml is drained. In addition, drains 3 and 4 are also short, as can be seen by observing the increasing patient volume fill. Even in this situation, however, the peak patient fill volume appears to reach about 2800 ml, i.e., about 140% of IPV, which is not ideal but is considerably less than the 161% required for a “moderate excess” intraperitoneal volume and is far less than the previous situation seen in  FIG. 4  or  FIG. 5 . 
     The total prescribed therapy volume is also used in the therapy depicted in  FIG. 6C . In  FIG. 6C , cycles 1, 3, 4 and 5 have short drains, as seen by the increasing patient fill volume over the six cycles, rising to almost 3000 ml. The tidal therapy shown in  FIG. 6C  shorts the last fill by about 100 ml in order to limit the IPV to 140% of the prescribed fill volume. This reduces the effectiveness of the 10,000 ml night therapy by about 1% based upon the actual fluid volume used, (10000−100)/10000=99%. Note that no alarms were necessary in any of the therapies depicted in  FIGS. 6A-6C . 
     If a fluid volume exceeding a predetermined limit remains unused nearly every day, a switch can be made from a 75% tidal therapy to a 65% tidal therapy allowing the base residual volume to increase by another 10%.  FIGS. 7A-7E  illustrate how such a therapy would limit the IPV while using all of the available fluid and maintaining the predicted dwell times. The patient would seldom observe a low drain volume alarm or a negative UF alarm when the base therapy is assumed to be tidal instead of CCPD. In  FIG. 7A , the therapy is now 65% tidal therapy, with 2 additional cycles over those of  FIG. 5  required in order to use the total prescribed therapy volume.  FIG. 7A  depicts a relatively ideal situation, in which a patient has all drains, except the first and the last, at about 1436 ml, representing 65% of 2040 ml of fill volume and 110 ml UF (110 ml UF over 7 cycles would remove about 770 ml UF). Each cycle is now a little shorter, about 1 hour and 15 minutes, for a total therapy time of about 8 hours and 45 minutes. In this idealized situation, the patient fill volume does not exceed 2200 ml, that is, does not go over about 110% of the prescribed fill volume. 
     The patient response in  FIG. 7B  is somewhat less ideal, with the first drain about 200 ml short (about 10% less than expected). Each drain is expected to be about 1436 ml, with 65% of 2040 ml fill volume (1326 ml) and 110 ml UF. While the first drain is short, the remaining drains are on target until the last drain, which is about 2350 ml. This therapy is still very well-behaved, with no alarms and patient IPV not exceeding the negligible excess level (less than 130% IPV). In  FIG. 7C , however, several drains are short, e.g., the first and second drains are about 200 ml short. The tidal therapy is offset each time by the 200 ml drain shortage, i.e., the tidal therapy volume increases by about 200 ml. Nevertheless, since the patient volume does not exceed the negligible excess level, the subsequent fills on cycles 2 and 3 are not shorted. Thus, the total therapy volume is used and the patient is still not upset by unnecessary alarms during the nocturnal therapy. Of course, if the volume were to exceed one of the thresholds, the controls could be programmed to short one or more of the cycle fill volumes. 
       FIG. 7D  depicts another patient therapy with some of the same shortcomings as  FIG. 7D . As in  FIG. 7D , there are two additional cycles and two short drains, drains 1 and 4, as seen by the increase in IPV at cycles 2 and 5. The negligible excess level is not exceeded, and as before, there are no alarms since the IPV level does not exceed the negligible excess level of less than 130% of patient volume. The total therapy volume is also used in this situation.  FIG. 7E  depicts another therapy performance. In this depiction, the first, third and fourth drains are each short by about 200 ml. Thus, the total patient volume rises by about 600 ml, which is still within the negligible excess IPV limit. 
     The therapies of  FIGS. 6A-6C  and  FIGS. 7A-7E  limit the maximum patient fill volume while using all the dialysis solution that is prescribed and available. At the same time, the therapy may be programmed to withhold therapy volume if the patient drain is much less than expected and the patient fill volume would cross an unacceptable threshold. Extra cycles may be added, each cycle an appropriate amount shorter, so that each fill is as effective as possible, the available solution is used, the available time is used, and alarms that disturb and disrupt a patient are kept to a minimum. 
     If drains continue to be shorted beyond the three shown in  FIG. 7E , however, such that maximum IPV grows (or is predicted to grow) to 2650 ml or greater (thirty percent or greater than initial fill volume), system  10  will stop offsetting the base patient volume and will short the next fill. The offset of the base patient volume is limited to 30% of the initial fill volume less the expected UF per cycle. System  10  in one embodiment posts a low drain volume alarm if ending the drain would result in an IPV on the next fill that would exceed 130% of the programmed fill volume not including UF. In one embodiment, system  10  limits the maximum IPV to 130% of the programmed fill volume (initial fill volume for tidal therapies). The offset limit can be adjusted to a value other than 30% if necessary, for example from 20% to 40%. The offset limit with tidal is similar to the negative UF limit that was imposed on the CCPD Therapy. 
     The method disclosed herein may progress gradually from an 85% CCPD (pseudo tidal) therapy to a 75% tidal therapy to a 65% tidal therapy and even to a 55% tidal therapy as it seeks to use all of the available dialysis solution, minimize the increased intra peritoneal volume and minimize the number of low drain alarms. Patient volume offsets will be allowed as long as they do not exceed a predetermined programmable limit that will be defaulted to 30%. Cycles will be added each time the tidal percentage decreases so that all of the dialysis solution volume is used. The base patient fill volume may also be adjusted up or down 5-10% during this process so that no fluid volume is wasted. 
     As discussed in more detail below, in one embodiment, system  10  trends UF based upon the dialysis solution used. For example, for a particular patient, the expected UF per therapy might be 500 ml with 1.5% dextrose, 750 ml with 2.0% dextrose, 1000 ml with 2.5% dextrose and 1500 ml with 4.25% dextrose. System  10  in one embodiment is programmed to notify the patient if the programmed total UF at the beginning of treatment differs by more than 20% from the trended UF for the particular dextrose concentration being used. 
     It is believed that system  10  will encounter fewer low drain volume alarms and virtually no negative UF alarms when compared to current CCPD therapies. The system will consistently use the total dialysate volume available and will not allow the patient&#39;s IPV to exceed 160% of the programmed fill volume. 
       FIG. 8  shows that the occurrence of non-initial drain alarms that are posted during a therapy would be expected to decrease to less than half (0.450/0.94) its current number if the minimum drain percentage were decreased from 85% to 65%. The alarm decrease would be to about ⅝ (0.6/0.94) if the minimum drain percentage were decreased to 75% from 65%. 
     System  10  in one embodiment also averages both the per cycle fill volume and per cycle dwell time after manual drains or bypasses in fill that alter the volume of fluid remaining, as will be explained below for  FIGS. 11A-11C . System  10  recalculates the therapy after such manual drain or bypass in fill that alters the volume of fluid remaining, calculating a revised average dwell time for each the remaining cycles. System  10  also calculates a revised (potentially) remaining number of cycles, which is calculated by dividing the total remaining therapy fluid volume less a “last fill” or “wet day” fill volume by the prescribed fill volume: 
       cycles remaining=(total remaining therapy volume−last fill volume (if any))/programmed fill volume
 
     System  10  in one implementation rounds up a fractional portion of a cycle if it is greater than 0.4 and divides both the total remaining therapy volume and therapy time equally over the rounded-up number of cycles remaining. Otherwise, the calculated number of cycles is truncated, and system  10  divides both the total remaining therapy volume and therapy time equally over the truncated number of cycles remaining. 
       FIGS. 9-10  illustrate how cycles can be added or at least not dropped in order to use all of the available fluid. The same concept carries over into drains when cycles are added. The principle is to use as much fluid as possible so as to give the maximum benefit to the patient while wasting as little fluid as possible. 
       FIG. 9  illustrates a treatment in which the first fill uses less fluid than normal because of a bypass of the fill, for example, if a user feels full and uses a manual drain or does not use a full fill. As a result, 500, 750 or 1000 ml of fluid (out of 2000 ml) was used in the first fill. System  10  spreads the remaining volume evenly over the remaining cycles, which are increased in  FIG. 8  from three to four. If the full 2000 ml is used in the first fill then the top or highest fill line shows that the therapy proceeds with three additional 2000 ml fills for total of 8000 ml. If only 500 ml is used in the first fill then the second or next highest fill line shows that the four fills at about 1875 ml are performed to use the total 8000 ml. If only 750 ml is used in the first fill then the third line shows that the four fills of about 1810 ml are performed to use the total 8000 ml. If only 1000 ml is used in the first fill then the lowest of the four fill lines shows that the four fills at about 1746 ml are performed to use the total 8000 ml. The result again is a more effective therapy. 
       FIG. 10  illustrates a scenario in which the first fill uses more fluid than normal because of a manual drain in the first fill. Here, system  10  averages the remaining therapy volume over the remaining four cycles instead of dropping a cycle and retaining the original fill volume. The result again is a more effective therapy. 
     Referring now to  FIG. 11A , flow diagram  100  illustrates one embodiment of a system  10  which may be used in either CCPD or tidal mode. The method begins at oval  102 . At block  104 , the user sets a programmable negative UF limit that is used to determine when to use shorter fill volumes after one or more incomplete drains when running a CCPD therapy or a Tidal therapy. As seen in blocks  106 ,  108 , the system  10  tracks UF and calls for a short fill if needed, in both CCPD mode and in Tidal mode. 
     At block  110 , system  10  performs an initial drain, followed at block  112  by performing a fill. Per block  114 , for drains after the initial drain, a shorter fill volume will be used, i.e., the fill is shorted, if the previous drain falls short of the target volume and the UF limit is exceeded. After the fill, a dwell at block  116  is performed, the dwell calculated as discussed below. After the dwell, a drain is performed at block  118 . Based on the drain, the number of remaining cycles and the dwell time is calculated at block  120 . The dwell time is calculated at block  120  to use all the allocated therapy time. In both the CCPD and tidal modes, system  10  tracks UF, offsets the residual patient volume and maintains the tidal fill volume if a tidal drain is incomplete as long as the sum of the increases in residual patient volume and expected UF do not exceed the negative UF Limit. 
     For CCPD therapies, system  10  calculates the remaining number of CCPD cycles using the equation: Cycles Remaining=(total remaining therapy volume−last fill volume (if any))/(programmed fill volume) 
     For Tidal therapies after an incomplete tidal drain, or after a complete full drain, system  10  calculates the remaining number of tidal cycles using the equation: Cycles Remaining=1+(Remaining Therapy Volume−Fill Volume−Last Fill Volume)/(Tidal PerCent*Fill Volume). 
     For Tidal therapies after a complete tidal drain, system  10  calculates the remaining number of tidal cycles using the equation: Cycles Remaining=(Remaining Therapy Volume−Last Fill Volume)/(Tidal PerCent*Fill Volume). 
     At diamond  122 , if the fractional number of cycles exceeds 0.85, the number of cycles is rounded up to the nearest integer, per block  124 . For example, if the fractional number of cycles remaining is 4.9, the number of cycles remaining is rounded up to 5; if the number of cycles remaining is 0.9, the number of cycles remaining is rounded up to 1. At diamond  126 , system  10  compares the number of remaining cycles to zero. If the number of cycles remaining is greater than zero, the next fill is performed, per block  112  and the process is repeated. If the number of cycles is zero, the therapy is complete, per block  130 . 
     Returning to diamond  122 , if the fractional number of cycles is less than 0.85, method  100  moves to block  128 , where the number of cycles is rounded down or truncated. At the next step, at diamond  126 , system  10  compares the number of remaining cycles to zero. If the number of cycles remaining is greater than zero, the next fill is performed, per block  112  and the process is repeated. If the number of cycles is zero, the therapy is complete, per block  130 . 
     Referring now to  FIG. 11B , flow diagram  140  illustrates one embodiment of a system  10  which may be used in either CCPD or tidal mode. The method begins at oval  142 . At block  144 , the user sets a programmable negative UF limit that is used to determine when to use shorter fill volumes after one or more incomplete drains when running a CCPD therapy or a Tidal therapy. As seen in blocks  146 ,  148 , the system  10  tracks UF and calls for a short fill if needed, in both CCPD mode and in Tidal mode. 
     At block  150 , system  10  performs an initial drain, followed by a fill at block  152 . If the previous drain falls short of the target volume and the UF limit is exceeded, then per block  154 , for drains after the initial drain, a shorter fill volume will be used, i.e., the fill is shorted. After the fill, a dwell at block  156  is performed, the dwell calculated as discussed below. After the dwell, a drain is performed at block  158 . Based on the drain, the number of remaining cycles and the dwell time is calculated at block  160  in order to use all of the allocated therapy time. In both the CCPD and tidal modes, system  10  tracks UF, offsets the residual patient volume and maintains the tidal fill volume if a tidal drain is incomplete, as long as the sum of the increases in residual patient volume and expected UF do not exceed the negative UF Limit. 
     For CCPD therapies, system  10  calculates the remaining number of CCPD cycles using the equation: Cycles Remaining=(total remaining therapy volume−last fill volume (if any))/(programmed fill volume). 
     For Tidal therapies after a tidal drain that ends prematurely due to an empty patient, or after a tidal full drain, system  10  calculates the remaining number of tidal cycles using the equation: Cycles Remaining=1+(Remaining Therapy Volume−Fill Volume Last Fill Volume)/(Tidal PerCent*Fill Volume). 
     For Tidal therapies after a normal tidal drain, system  10  calculates the remaining number of tidal cycles using the equation: Cycles Remaining=(Remaining Therapy Volume−Last Fill Volume)/(Tidal PerCent*Fill Volume). 
     At diamond  162 , if the fractional number of cycles exceeds 0.85, the number of cycles is rounded up to the nearest integer, per block  164 . For example, if the fractional number of cycles remaining is 4.9, the number of cycles remaining is rounded up to 5. At diamond  166 , system  10  compares the number of remaining cycles to zero. If the number of cycles remaining is greater than zero, the next fill is performed, per block  152  and the process is repeated. If the number of cycles is zero, the therapy is complete, per block  170 . 
     Returning to diamond  162 , if the fractional number of cycles is less than 0.85, the process path of method  100  moves to diamond  168 . At this point, the fractional number of cycles is compared to 0.40 (40% of a cycle). If the fractional number remaining is less than 0.40, the number of cycles is rounded down, or truncated at block  172  and the process moves to diamond  166 , where the remaining number of cycles is compared to zero. If the number of cycles remaining is greater than zero, the next fill is performed, per block  152  and the process is repeated. If the number of cycles is zero, the therapy is complete, per block  170 . 
     Returning to diamond  168 , if the fractional number of cycles is greater than 0.40, a new higher fill volume is calculated with a truncated number of cycles at block  174 . At diamond  176 , the ratio of Increased Fill to Prescribed Fill is calculated. If the ratio is not greater than 1.05, i.e., the volume increase is less than 5%, the increased fill volume is taken as the new set point at block  178 . The number of cycles is truncated at block  172 , and the number of remaining cycles is then compared to zero at diamond  166 . If no cycles remain, the therapy is completed at block  170 . If 1 or more cycles remains, the process advances to block  152  and is repeated. 
     Returning to diamond  176 , if the increase is greater than 5%, a decreased fill volume is calculated, based on a rounded-up number of cycles at block  180 . The number of cycles is rounded up at block  182  and the set fill volume is reset to a decreased fill volume. The process then returns to diamond  166  for another cycle if appropriate. 
     Example for Patient A: Tables 1, 2, 3 and 4 contain system  10  drain volume/fill volume (DV/FV) ratios, UF/fill (UF/FV) volume and ratios of unused fluid volume/fill (Unused Fluid/FV) volume ratios for CCPD therapies for Patient A with the negative UF limits set to 40%, 30%, 25% and 20%, respectively. The average drain volume/fill volume ratio in Drain 5 of 5 decreases as the fraction of unused fluid volume increases when the negative UF limit decreases from 40% to 20%. The maximum drain/fill volume (DV/FV) ratio decreases from 1.69 to 1.45. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 5 x 2 Liter CCPD Therapy with Negative UF Limit Set to 40% 
               
               
                 Patient A 
               
            
           
           
               
               
               
               
            
               
                   
                 DV/FV 
                 UF/FV 
                 Unused Fluid/FV 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Day 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1 
                 0.85 
                 0.89 
                 0.93 
                 1.02 
                 1.71 
                   
                   
                 −0.15 
                 −0.26 
                 −0.33 
                 −0.31 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 2 
                 0.85 
                 0.87 
                 0.97 
                 0.96 
                 1.75 
                   
                   
                 −0.15 
                 −0.28 
                 −0.31 
                 −0.35 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 3 
                 0.87 
                 0.89 
                 0.94 
                 0.95 
                 1.75 
                   
                   
                 −0.13 
                 −0.24 
                 −0.3 
                 −0.35 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 4 
                 0.87 
                 0.9 
                 0.99 
                 1.04 
                 1.6 
                   
                   
                 −0.13 
                 −0.23 
                 −0.24 
                 −0.2 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 5 
                 0.86 
                 0.9 
                 0.94 
                 1.04 
                 1.66 
                   
                   
                 −0.14 
                 −0.24 
                 −0.3 
                 −0.26 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 6 
                 0.85 
                 0.9 
                 0.93 
                 0.97 
                 1.75 
                   
                   
                 −0.15 
                 −0.25 
                 −0.32 
                 −0.35 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 7 
                 0.85 
                 0.91 
                 0.99 
                 0.97 
                 1.68 
                   
                   
                 −0.15 
                 −0.24 
                 −0.25 
                 −0.28 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 8 
                 0.85 
                 0.89 
                 0.98 
                 1.04 
                 1.64 
                   
                   
                 −0.15 
                 −0.26 
                 −0.28 
                 −0.24 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 9 
                 0.86 
                 0.87 
                 0.98 
                 1.05 
                 1.64 
                   
                   
                 −0.14 
                 −0.27 
                 −0.29 
                 −0.24 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 10 
                 0.85 
                 0.87 
                 0.94 
                 0.95 
                 1.79 
                   
                   
                 −0.15 
                 −0.28 
                 −0.34 
                 −0.39 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 11 
                 0.87 
                 0.87 
                 0.95 
                 0.98 
                 1.73 
                   
                   
                 −0.13 
                 −0.26 
                 −0.31 
                 −0.33 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 12 
                 0.85 
                 0.89 
                 0.97 
                 1 
                 1.69 
                   
                   
                 −0.15 
                 −0.26 
                 −0.29 
                 −0.29 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 13 
                 0.85 
                 0.89 
                 0.98 
                 1.04 
                 1.64 
                   
                   
                 −0.15 
                 −0.26 
                 −0.28 
                 −0.24 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 14 
                 0.87 
                 0.89 
                 0.99 
                 1.02 
                 1.63 
                   
                   
                 −0.13 
                 −0.24 
                 −0.25 
                 −0.23 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 15 
                 0.87 
                 0.87 
                 0.95 
                 0.99 
                 1.72 
                   
                   
                 −0.13 
                 −0.26 
                 −0.31 
                 −0.32 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 16 
                 0.87 
                 0.88 
                 0.94 
                 1.05 
                 1.66 
                   
                   
                 −0.13 
                 −0.25 
                 −0.31 
                 −0.26 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 17 
                 0.85 
                 0.9 
                 0.95 
                 1.04 
                 1.66 
                   
                   
                 −0.15 
                 −0.25 
                 −0.3 
                 −0.26 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 18 
                 0.85 
                 0.88 
                 0.94 
                 1 
                 1.73 
                   
                   
                 −0.15 
                 −0.27 
                 −0.33 
                 −0.33 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 19 
                 0.87 
                 0.91 
                 0.92 
                 1.02 
                 1.68 
                   
                   
                 −0.13 
                 −0.22 
                 −0.3 
                 −0.28 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 20 
                 0.86 
                 0.9 
                 0.93 
                 0.99 
                 1.72 
                   
                   
                 −0.14 
                 −0.24 
                 −0.31 
                 −0.32 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 AVE 
                 0.86 
                 0.89 
                 0.96 
                 1.01 
                 1.69 
                   
                   
                 −0.14 
                 −0.25 
                 −0.30 
                 −0.29 
                 0.40 
                   
                   
                 0.00 
                 0.00 
                 0.00 
                 0.00 
                 0.00 
                   
                   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 5 x 2 Liter CCPD Therapy with Negative UF Limit Set to 30% 
               
               
                 Patient A  
               
            
           
           
               
               
               
               
            
               
                   
                 DV/FV 
                 UF/FV 
                 Unused Fluid/FV 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Day 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1 
                 0.86 
                 0.88 
                 0.96 
                 1 
                 1.7 
                   
                   
                 −0.14 
                 −0.26 
                 −0.3 
                 −0.3 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 2 
                 0.85 
                 0.91 
                 0.96 
                 0.95 
                 1.7 
                   
                   
                 −0.15 
                 −0.24 
                 −0.28 
                 −0.33 
                 0.37 
                   
                   
                 0 
                 0 
                 0 
                 −0.03 
                 −0.03 
                   
                   
               
               
                 3 
                 0.87 
                 0.89 
                 0.93 
                 0.98 
                 1.69 
                   
                   
                 −0.13 
                 −0.24 
                 −0.31 
                 −0.33 
                 0.36 
                   
                   
                 0 
                 0 
                 −0.01 
                 −0.04 
                 −0.04 
                   
                   
               
               
                 4 
                 0.86 
                 0.91 
                 0.93 
                 1.02 
                 1.68 
                   
                   
                 −0.14 
                 −0.23 
                 −0.3 
                 −0.28 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 5 
                 0.85 
                 0.87 
                 0.92 
                 0.98 
                 1.64 
                   
                   
                 −0.15 
                 −0.28 
                 −0.36 
                 −0.38 
                 0.26 
                   
                   
                 0 
                 0 
                 −0.06 
                 −0.14 
                 −0.14 
                   
                   
               
               
                 6 
                 0.86 
                 0.89 
                 0.92 
                 1.01 
                 1.67 
                   
                   
                 −0.14 
                 −0.25 
                 −0.33 
                 −0.32 
                 0.35 
                   
                   
                 0 
                 0 
                 −0.03 
                 −0.05 
                 −0.05 
                   
                   
               
               
                 7 
                 0.85 
                 0.9 
                 0.98 
                 1 
                 1.67 
                   
                   
                 −0.15 
                 −0.25 
                 −0.27 
                 −0.27 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 8 
                 0.86 
                 0.9 
                 0.95 
                 1.05 
                 1.64 
                   
                   
                 −0.14 
                 −0.24 
                 −0.29 
                 −0.24 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 9 
                 0.87 
                 0.88 
                 0.92 
                 1.04 
                 1.66 
                   
                   
                 −0.13 
                 −0.25 
                 −0.33 
                 −0.29 
                 0.37 
                   
                   
                 0 
                 0 
                 −0.03 
                 −0.03 
                 −0.03 
                   
                   
               
               
                 10 
                 0.85 
                 0.91 
                 0.95 
                 1.04 
                 1.65 
                   
                   
                 −0.15 
                 −0.24 
                 −0.29 
                 −0.25 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 11 
                 0.85 
                 0.9 
                 0.99 
                 1.02 
                 1.64 
                   
                   
                 −0.15 
                 −0.25 
                 −0.26 
                 −0.24 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 12 
                 0.85 
                 0.87 
                 0.91 
                 0.97 
                 1.63 
                   
                   
                 −0.15 
                 −0.28 
                 −0.37 
                 −0.4 
                 0.23 
                   
                   
                 0 
                 0 
                 −0.07 
                 −0.17 
                 −0.17 
                   
                   
               
               
                 13 
                 0.87 
                 0.89 
                 0.93 
                 0.99 
                 1.69 
                   
                   
                 −0.13 
                 −0.24 
                 −0.31 
                 −0.32 
                 0.37 
                   
                   
                 0 
                 0 
                 −0.01 
                 −0.03 
                 −0.03 
                   
                   
               
               
                 14 
                 0.87 
                 0.89 
                 0.95 
                 0.95 
                 1.7 
                   
                   
                 −0.13 
                 −0.24 
                 −0.29 
                 −0.34 
                 0.36 
                   
                   
                 0 
                 0 
                 0 
                 −0.04 
                 −0.04 
                   
                   
               
               
                 15 
                 0.86 
                 0.9 
                 0.96 
                 0.98 
                 1.7 
                   
                   
                 −0.14 
                 −0.24 
                 −0.28 
                 −0.3 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 16 
                 0.85 
                 0.87 
                 0.93 
                 0.96 
                 1.65 
                   
                   
                 −0.15 
                 −0.28 
                 −0.35 
                 −0.39 
                 0.26 
                   
                   
                 0 
                 0 
                 −0.05 
                 −0.14 
                 −0.14 
                   
                   
               
               
                 17 
                 0.85 
                 0.91 
                 0.97 
                 1.03 
                 1.64 
                   
                   
                 −0.15 
                 −0.24 
                 −0.27 
                 −0.24 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 18 
                 0.86 
                 0.91 
                 0.91 
                 1.04 
                 1.66 
                   
                   
                 −0.14 
                 −0.23 
                 −0.32 
                 −0.28 
                 0.38 
                   
                   
                 0 
                 0 
                 −0.02 
                 −0.02 
                 −0.02 
                   
                   
               
               
                 19 
                 0.87 
                 0.91 
                 0.95 
                 1.01 
                 1.66 
                   
                   
                 −0.13 
                 −0.22 
                 −0.27 
                 −0.26 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 20 
                 0.87 
                 0.89 
                 0.99 
                 0.99 
                 1.66 
                   
                   
                 −0.13 
                 −0.24 
                 −0.25 
                 −0.26 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 AVE 
                 0.86 
                 0.89 
                 0.95 
                 1.00 
                 1.67 
                   
                   
                 −0.14 
                 −0.25 
                 −0.30 
                 −0.30 
                 0.37 
                   
                   
                 0.00 
                 0.00 
                 −0.01 
                 −0.03 
                 −0.03 
                   
                   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 5 x 2 Liter CCPD Therapy with Negative UF Limit Set to 25% 
               
               
                 Patient A 
               
            
           
           
               
               
               
               
            
               
                   
                 DV/FV 
                 UF/FV 
                 Unused Fluid/FV 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Day 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1 
                 0.87 
                 0.9 
                 0.95 
                 0.95 
                 1.62 
                   
                   
                 −0.13 
                 −0.23 
                 −0.28 
                 −0.33 
                 0.29 
                   
                   
                 0 
                 0 
                 −0.03 
                 −0.11 
                 −0.11 
                   
                   
               
               
                 2 
                 0.87 
                 0.89 
                 0.92 
                 1.04 
                 1.58 
                   
                   
                 −0.13 
                 −0.24 
                 −0.32 
                 −0.28 
                 0.30 
                   
                   
                 0 
                 0 
                 −0.07 
                 −0.1 
                 −0.1 
                   
                   
               
               
                 3 
                 0.86 
                 0.91 
                 0.91 
                 1 
                 1.58 
                   
                   
                 −0.14 
                 −0.23 
                 −0.32 
                 −0.32 
                 0.26 
                   
                   
                 0 
                 0 
                 −0.07 
                 −0.14 
                 −0.14 
                   
                   
               
               
                 4 
                 0.86 
                 0.89 
                 0.93 
                 0.98 
                 1.58 
                   
                   
                 −0.14 
                 −0.25 
                 −0.32 
                 −0.34 
                 0.24 
                   
                   
                 0 
                 0 
                 −0.07 
                 −0.16 
                 −0.16 
                   
                   
               
               
                 5 
                 0.86 
                 0.88 
                 0.95 
                 1.05 
                 1.58 
                   
                   
                 −0.14 
                 −0.26 
                 −0.31 
                 −0.26 
                 0.32 
                   
                   
                 0 
                 −0.01 
                 −0.07 
                 −0.08 
                 −0.08 
                   
                   
               
               
                 6 
                 0.86 
                 0.91 
                 0.91 
                 1.02 
                 1.58 
                   
                   
                 −0.14 
                 −0.23 
                 −0.32 
                 −0.3 
                 0.28 
                   
                   
                 0 
                 0 
                 −0.07 
                 −0.12 
                 −0.12 
                   
                   
               
               
                 7 
                 0.87 
                 0.89 
                 0.93 
                 0.99 
                 1.59 
                   
                   
                 −0.13 
                 −0.24 
                 −0.31 
                 −0.32 
                 0.27 
                   
                   
                 0 
                 0 
                 −0.06 
                 −0.13 
                 −0.13 
                   
                   
               
               
                 8 
                 0.85 
                 0.89 
                 0.99 
                 0.95 
                 1.62 
                   
                   
                 −0.15 
                 −0.26 
                 −0.27 
                 −0.32 
                 0.30 
                   
                   
                 0 
                 −0.01 
                 −0.03 
                 −0.1 
                 −0.1 
                   
                   
               
               
                 9 
                 0.87 
                 0.89 
                 0.99 
                 1.02 
                 1.63 
                   
                   
                 −0.13 
                 −0.24 
                 −0.25 
                 −0.23 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 10 
                 0.86 
                 0.89 
                 0.98 
                 0.97 
                 1.63 
                   
                   
                 −0.14 
                 −0.25 
                 −0.27 
                 −0.3 
                 0.33 
                   
                   
                 0 
                 0 
                 −0.02 
                 −0.07 
                 −0.07 
                   
                   
               
               
                 11 
                 0.86 
                 0.91 
                 0.96 
                 0.98 
                 1.63 
                   
                   
                 −0.14 
                 −0.23 
                 −0.27 
                 −0.29 
                 0.34 
                   
                   
                 0 
                 0 
                 −0.02 
                 −0.06 
                 −0.06 
                   
                   
               
               
                 12 
                 0.85 
                 0.89 
                 0.95 
                 1.01 
                 1.58 
                   
                   
                 −0.15 
                 −0.26 
                 −0.31 
                 −0.3 
                 0.28 
                   
                   
                 0 
                 −0.01 
                 −0.07 
                 −0.12 
                 −0.12 
                   
                   
               
               
                 13 
                 0.87 
                 0.87 
                 0.99 
                 0.99 
                 1.62 
                   
                   
                 −0.13 
                 −0.26 
                 −0.27 
                 −0.28 
                 0.34 
                   
                   
                 0 
                 −0.01 
                 −0.03 
                 −0.06 
                 −0.06 
                   
                   
               
               
                 14 
                 0.85 
                 0.87 
                 0.99 
                 1.04 
                 1.58 
                   
                   
                 −0.15 
                 −0.28 
                 −0.29 
                 −0.25 
                 0.33 
                   
                   
                 0 
                 −0.03 
                 −0.07 
                 −0.07 
                 −0.07 
                   
                   
               
               
                 15 
                 0.87 
                 0.89 
                 0.94 
                 1.03 
                 1.6 
                   
                   
                 −0.13 
                 −0.24 
                 −0.3 
                 −0.27 
                 0.33 
                   
                   
                 0 
                 0 
                 −0.05 
                 −0.07 
                 −0.07 
                   
                   
               
               
                 16 
                 0.85 
                 0.87 
                 0.96 
                 1.02 
                 1.56 
                   
                   
                 −0.15 
                 −0.28 
                 −0.32 
                 −0.3 
                 0.25 
                   
                   
                 0 
                 −0.03 
                 −0.1 
                 −0.16 
                 −0.15 
                   
                   
               
               
                 17 
                 0.85 
                 0.89 
                 0.98 
                 0.99 
                 1.61 
                   
                   
                 −0.15 
                 −0.26 
                 −0.28 
                 −0.29 
                 0.32 
                   
                   
                 0 
                 −0.01 
                 −0.04 
                 −0.08 
                 −0.08 
                   
                   
               
               
                 18 
                 0.86 
                 0.91 
                 0.97 
                 0.96 
                 1.64 
                   
                   
                 −0.14 
                 −0.23 
                 −0.26 
                 −0.3 
                 0.34 
                   
                   
                 0 
                 0 
                 −0.01 
                 −0.06 
                 −0.06 
                   
                   
               
               
                 19 
                 0.87 
                 0.89 
                 0.92 
                 1.04 
                 1.58 
                   
                   
                 −0.13 
                 −0.24 
                 −0.32 
                 −0.28 
                 0.30 
                   
                   
                 0 
                 0 
                 −0.07 
                 −0.1 
                 −0.1 
                   
                   
               
               
                 20 
                 0.86 
                 0.88 
                 0.97 
                 0.95 
                 1.6 
                   
                   
                 −0.14 
                 −0.26 
                 −0.29 
                 −0.34 
                 0.26 
                   
                   
                 0 
                 −0.01 
                 −0.05 
                 −0.14 
                 −0.14 
                   
                   
               
               
                 AVE 
                 0.86 
                 0.89 
                 0.95 
                 1.00 
                 1.60 
                   
                   
                 −0.14 
                 −0.25 
                 −0.29 
                 −0.30 
                 0.30 
                   
                   
                 0.00 
                 −0.01 
                 −0.05 
                 −0.10 
                 −0.1 
                   
                   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 5 x 2 Liter CCPD Therapy with Negative UF Limit Set to 20% 
               
               
                 Patient A 
               
            
           
           
               
               
               
               
            
               
                   
                 DV/FV 
                 UF/FV 
                 Unused Fluid/FV 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Day 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1 
                 0.86 
                 0.9 
                 0.96 
                 0.95 
                 1.48 
                   
                   
                 −0.14 
                 −0.24 
                 −0.28 
                 −0.33 
                 0.15 
                   
                   
                 0 
                 −0.04 
                 −0.12 
                 −0.25 
                 −0.25 
                   
                   
               
               
                 2 
                 0.87 
                 0.87 
                 0.93 
                 0.98 
                 1.41 
                   
                   
                 −0.13 
                 −0.26 
                 −0.33 
                 −0.35 
                 0.06 
                   
                   
                 0 
                 −0.06 
                 −0.19 
                 −0.34 
                 −0.34 
                   
                   
               
               
                 3 
                 0.85 
                 0.89 
                 0.97 
                 1 
                 1.45 
                   
                   
                 −0.15 
                 −0.26 
                 −0.29 
                 −0.29 
                 0.16 
                   
                   
                 0 
                 −0.06 
                 −0.15 
                 −0.24 
                 −0.24 
                   
                   
               
               
                 4 
                 0.87 
                 0.89 
                 0.94 
                 1.02 
                 1.46 
                   
                   
                 −0.13 
                 −0.24 
                 −0.3 
                 −0.28 
                 0.18 
                   
                   
                 0 
                 −0.04 
                 −0.14 
                 −0.22 
                 −0.22 
                   
                   
               
               
                 5 
                 0.85 
                 0.91 
                 0.99 
                 1 
                 1.51 
                   
                   
                 −0.15 
                 −0.24 
                 −0.25 
                 −0.25 
                 0.26 
                   
                   
                 0 
                 −0.04 
                 −0.09 
                 −0.14 
                 −0.14 
                   
                   
               
               
                 6 
                 0.87 
                 0.89 
                 0.96 
                 0.95 
                 1.48 
                   
                   
                 −0.13 
                 −0.24 
                 −0.28 
                 −0.33 
                 0.15 
                   
                   
                 0 
                 −0.04 
                 −0.12 
                 −0.25 
                 −0.25 
                   
                   
               
               
                 7 
                 0.85 
                 0.89 
                 0.96 
                 0.96 
                 1.44 
                   
                   
                 −0.15 
                 −0.26 
                 −0.3 
                 −0.34 
                 0.10 
                   
                   
                 0 
                 −0.06 
                 −0.16 
                 −0.3 
                 −0.3 
                   
                   
               
               
                 8 
                 0.86 
                 0.88 
                 0.96 
                 1.05 
                 1.44 
                   
                   
                 −0.14 
                 −0.26 
                 −0.3 
                 −0.25 
                 0.19 
                   
                   
                 0 
                 −0.06 
                 −0.16 
                 −0.21 
                 −0.21 
                   
                   
               
               
                 9 
                 0.85 
                 0.88 
                 0.96 
                 1.04 
                 1.42 
                   
                   
                 −0.15 
                 −0.27 
                 −0.31 
                 −0.27 
                 0.15 
                   
                   
                 0 
                 −0.07 
                 −0.18 
                 −0.25 
                 −0.25 
                   
                   
               
               
                 10 
                 0.86 
                 0.91 
                 0.92 
                 1 
                 1.46 
                   
                   
                 −0.14 
                 −0.23 
                 −0.31 
                 −0.31 
                 0.15 
                   
                   
                 0 
                 −0.03 
                 −0.14 
                 −0.25 
                 −0.25 
                   
                   
               
               
                 11 
                 0.86 
                 0.87 
                 0.95 
                 0.97 
                 1.41 
                   
                   
                 −0.14 
                 −0.27 
                 −0.32 
                 −0.35 
                 0.06 
                   
                   
                 0 
                 −0.07 
                 −0.19 
                 −0.34 
                 −0.34 
                   
                   
               
               
                 12 
                 0.87 
                 0.9 
                 0.91 
                 1.05 
                 1.45 
                   
                   
                 −0.13 
                 −0.23 
                 −0.32 
                 −0.27 
                 0.18 
                   
                   
                 0 
                 −0.03 
                 −0.15 
                 −0.22 
                 −0.22 
                   
                   
               
               
                 13 
                 0.85 
                 0.88 
                 0.96 
                 0.96 
                 1.42 
                   
                   
                 −0.15 
                 −0.27 
                 −0.31 
                 −0.35 
                 0.07 
                   
                   
                 0 
                 −0.07 
                 −0.18 
                 −0.33 
                 −0.33 
                   
                   
               
               
                 14 
                 0.87 
                 0.89 
                 0.93 
                 1.03 
                 1.45 
                   
                   
                 −0.13 
                 −0.24 
                 −0.31 
                 −0.28 
                 0.17 
                   
                   
                 0 
                 −0.04 
                 −0.15 
                 −0.23 
                 −0.23 
                   
                   
               
               
                 15 
                 0.87 
                 0.88 
                 0.98 
                 0.96 
                 1.48 
                   
                   
                 −0.13 
                 −0.25 
                 −0.27 
                 −0.31 
                 0.17 
                   
                   
                 0 
                 −0.05 
                 −0.12 
                 −0.23 
                 −0.23 
                   
                   
               
               
                 16 
                 0.85 
                 0.87 
                 0.94 
                 0.98 
                 1.38 
                   
                   
                 −0.15 
                 −0.28 
                 −0.34 
                 −0.36 
                 0.02 
                   
                   
                 0 
                 −0.08 
                 −0.22 
                 −0.38 
                 −0.38 
                   
                   
               
               
                 17 
                 0.87 
                 0.91 
                 0.91 
                 0.99 
                 1.47 
                   
                   
                 −0.13 
                 −0.22 
                 −0.31 
                 −0.32 
                 0.15 
                   
                   
                 0 
                 −0.02 
                 −0.13 
                 −0.25 
                 −0.25 
                   
                   
               
               
                 18 
                 0.87 
                 0.91 
                 0.94 
                 1.04 
                 1.5 
                   
                   
                 −0.13 
                 −0.22 
                 −0.28 
                 −0.24 
                 0.26 
                   
                   
                 0 
                 −0.02 
                 −0.1 
                 −0.14 
                 −0.14 
                   
                   
               
               
                 19 
                 0.85 
                 0.9 
                 0.92 
                 1.02 
                 1.42 
                   
                   
                 −0.15 
                 −0.25 
                 −0.33 
                 −0.31 
                 0.11 
                   
                   
                 0 
                 −0.05 
                 −0.18 
                 −0.29 
                 −0.29 
                   
                   
               
               
                 20 
                 0.86 
                 0.91 
                 0.96 
                 1.03 
                 1.5 
                   
                   
                 −0.14 
                 −0.23 
                 −0.27 
                 −0.24 
                 0.26 
                   
                   
                 0 
                 −0.03 
                 −0.1 
                 −0.14 
                 −0.14 
                   
                   
               
               
                 AVE 
                 0.86 
                 0.89 
                 0.95 
                 1.00 
                 1.45 
                   
                   
                 −0.14 
                 −0.25 
                 −0.30 
                 −0.30 
                 0.15 
                   
                   
                 0.00 
                 −0.05 
                 −0.15 
                 −0.25 
                 −0.25 
                   
                   
               
               
                   
               
            
           
         
       
     
     Example for Patient B: Tables 5, 6, 7 and 8 contain system  10  drain volume/fill volume ratios, UF/fill volume ratios and unused fluid volume/fill volume ratios for CCPD therapies for Patient B with the negative UF limits set to 40%, 30%, 25% and 20%, respectively. The average drain volume/fill volume (DV/FV) ratio in Drain 5 of 5 decreases as the fraction of unused fluid volume increases when the negative UF Limit decreases from 40% to 20%. The maximum DV/FV ratio decreases from 1.67 to 1.43, as seen in  FIG. 5-8 . 
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 5 x 2 Liter CCPD Therapy with Negative UF Limit Set to 40% 
               
               
                 Patient B 
               
            
           
           
               
               
               
               
            
               
                   
                 DV/FV 
                 UF/FV 
                 Unused Fluid/FV 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Day 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1 
                 0.87 
                 0.89 
                 0.96 
                 1.14 
                 1.54 
                   
                   
                 −0.13 
                 −0.24 
                 −0.28 
                 −0.14 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 2 
                 0.86 
                 0.93 
                 1.05 
                 1.03 
                 1.53 
                   
                   
                 −0.14 
                 −0.21 
                 −0.16 
                 −0.13 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 3 
                 0.87 
                 0.87 
                 0.85 
                 0.98 
                 1.79 
                   
                   
                 −0.13 
                 −0.26 
                 −0.41 
                 −0.43 
                 0.36 
                   
                   
                 0 
                 0 
                 −0.01 
                 −0.04 
                 −0.04 
                   
                   
               
               
                 4 
                 0.87 
                 0.9 
                 0.87 
                 1.03 
                 1.73 
                   
                   
                 −0.13 
                 −0.23 
                 −0.36 
                 −0.33 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 5 
                 0.85 
                 0.86 
                 1.05 
                 0.94 
                 1.7 
                   
                   
                 −0.15 
                 −0.29 
                 −0.24 
                 −0.3 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 6 
                 0.85 
                 0.89 
                 0.99 
                 1.09 
                 1.58 
                   
                   
                 −0.15 
                 −0.26 
                 −0.27 
                 −0.18 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 7 
                 0.85 
                 0.87 
                 0.98 
                 0.91 
                 1.79 
                   
                   
                 −0.15 
                 −0.28 
                 −0.3 
                 −0.39 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 8 
                 0.85 
                 0.93 
                 0.88 
                 0.89 
                 1.8 
                   
                   
                 −0.15 
                 −0.22 
                 −0.34 
                 −0.45 
                 0.35 
                   
                   
                 0 
                 0 
                 0 
                 −0.05 
                 −0.05 
                   
                   
               
               
                 9 
                 0.86 
                 0.89 
                 0.95 
                 1.15 
                 1.55 
                   
                   
                 −0.14 
                 −0.25 
                 −0.3 
                 −0.15 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 10 
                 0.85 
                 0.87 
                 0.87 
                 0.94 
                 1.79 
                   
                   
                 −0.15 
                 −0.28 
                 −0.41 
                 −0.47 
                 0.32 
                   
                   
                 0 
                 0 
                 −0.01 
                 −0.08 
                 −0.08 
                   
                   
               
               
                 11 
                 0.86 
                 0.91 
                 0.85 
                 1 
                 1.78 
                   
                   
                 −0.14 
                 −0.23 
                 −0.38 
                 −0.38 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 12 
                 0.86 
                 0.89 
                 1.03 
                 1 
                 1.62 
                   
                   
                 −0.14 
                 −0.25 
                 −0.22 
                 −0.22 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 13 
                 0.85 
                 0.87 
                 1.03 
                 0.96 
                 1.69 
                   
                   
                 −0.15 
                 −0.28 
                 −0.25 
                 −0.29 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 14 
                 0.86 
                 0.93 
                 1.04 
                 1.05 
                 1.52 
                   
                   
                 −0.14 
                 −0.21 
                 −0.17 
                 −0.12 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 15 
                 0.87 
                 0.91 
                 1.01 
                 0.94 
                 1.67 
                   
                   
                 −0.13 
                 −0.22 
                 −0.21 
                 −0.27 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 16 
                 0.87 
                 0.9 
                 0.93 
                 0.87 
                 1.8 
                   
                   
                 −0.13 
                 −0.23 
                 −0.3 
                 −0.43 
                 0.37 
                   
                   
                 0 
                 0 
                 0 
                 −0.03 
                 −0.03 
                   
                   
               
               
                 17 
                 0.87 
                 0.85 
                 0.86 
                 1.15 
                 1.65 
                   
                   
                 −0.13 
                 −0.28 
                 −0.42 
                 −0.27 
                 0.38 
                   
                   
                 0 
                 0 
                 −0.02 
                 −0.02 
                 −0.02 
                   
                   
               
               
                 18 
                 0.85 
                 0.88 
                 1.04 
                 1.07 
                 1.56 
                   
                   
                 −0.15 
                 −0.27 
                 −0.23 
                 −0.16 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 19 
                 0.87 
                 0.92 
                 0.91 
                 1.09 
                 1.61 
                   
                   
                 −0.13 
                 −0.21 
                 −0.3 
                 −0.21 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 20 
                 0.87 
                 0.89 
                 1.04 
                 1 
                 1.6 
                   
                   
                 −0.13 
                 −0.24 
                 −0.2 
                 −0.2 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 AVE 
                 0.86 
                 0.89 
                 0.96 
                 1.01 
                 1.67 
                   
                   
                 −0.14 
                 −0.25 
                 −0.29 
                 −0.28 
                 0.39 
                   
                   
                 0.00 
                 0.00 
                 0.00 
                 −0.01 
                 −0.01 
                   
                   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 5 x 2 Liter CCPD Therapy with Negative UF Limit Set to 30% 
               
               
                 Patient B 
               
            
           
           
               
               
               
               
            
               
                   
                 DV/FV 
                 UF/FV 
                 Unused Fluid/FV 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Day 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1 
                 0.87 
                 0.93 
                 0.94 
                 0.98 
                 1.68 
                   
                   
                 −0.13 
                 −0.2 
                 −0.26 
                 −0.28 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 2 
                 0.87 
                 0.85 
                 0.92 
                 1.08 
                 1.62 
                   
                   
                 −0.13 
                 −0.28 
                 −0.36 
                 −0.28 
                 0.34 
                   
                   
                 0 
                 0 
                 −0.06 
                 −0.06 
                 −0.06 
                   
                   
               
               
                 3 
                 0.85 
                 0.93 
                 1.05 
                 1.08 
                 1.49 
                   
                   
                 −0.15 
                 −0.22 
                 −0.17 
                 −0.09 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 4 
                 0.87 
                 0.9 
                 0.91 
                 1.1 
                 1.6 
                   
                   
                 −0.13 
                 −0.23 
                 −0.32 
                 −0.22 
                 0.38 
                   
                   
                 0 
                 0 
                 −0.02 
                 −0.02 
                 −0.02 
                   
                   
               
               
                 5 
                 0.86 
                 0.91 
                 0.95 
                 0.93 
                 1.7 
                   
                   
                 −0.14 
                 −0.23 
                 −0.28 
                 −0.35 
                 0.35 
                   
                   
                 0 
                 0 
                 0 
                 −0.05 
                 −0.05 
                   
                   
               
               
                 6 
                 0.87 
                 0.85 
                 1.03 
                 0.9 
                 1.7 
                   
                   
                 −0.13 
                 −0.28 
                 −0.25 
                 −0.35 
                 0.35 
                   
                   
                 0 
                 0 
                 0 
                 −0.05 
                 −0.05 
                   
                   
               
               
                 7 
                 0.86 
                 0.91 
                 0.93 
                 0.92 
                 1.7 
                   
                   
                 −0.14 
                 −0.23 
                 −0.3 
                 −0.38 
                 0.32 
                   
                   
                 0 
                 0 
                 0 
                 −0.08 
                 −0.08 
                   
                   
               
               
                 8 
                 0.87 
                 0.88 
                 0.99 
                 1.12 
                 1.54 
                   
                   
                 −0.13 
                 −0.25 
                 −0.26 
                 −0.14 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 9 
                 0.87 
                 0.89 
                 0.91 
                 1.06 
                 1.64 
                   
                   
                 −0.13 
                 −0.24 
                 −0.33 
                 −0.27 
                 0.37 
                   
                   
                 0 
                 0 
                 −0.03 
                 −0.03 
                 −0.03 
                   
                   
               
               
                 10 
                 0.86 
                 0.85 
                 1.05 
                 1.13 
                 1.51 
                   
                   
                 −0.14 
                 −0.29 
                 −0.24 
                 −0.11 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 11 
                 0.85 
                 0.9 
                 0.91 
                 1.1 
                 1.6 
                   
                   
                 −0.15 
                 −0.25 
                 −0.34 
                 −0.24 
                 0.36 
                   
                   
                 0 
                 0 
                 −0.04 
                 −0.04 
                 −0.04 
                   
                   
               
               
                 12 
                 0.86 
                 0.91 
                 1.02 
                 1.11 
                 1.5 
                   
                   
                 −0.14 
                 −0.23 
                 −0.21 
                 −0.1 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 13 
                 0.85 
                 0.85 
                 1.05 
                 1.14 
                 1.51 
                   
                   
                 −0.15 
                 −0.3 
                 −0.25 
                 −0.11 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 14 
                 0.85 
                 0.9 
                 1.05 
                 1 
                 1.6 
                   
                   
                 −0.15 
                 −0.25 
                 −0.2 
                 −0.2 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 15 
                 0.86 
                 0.93 
                 0.87 
                 0.97 
                 1.66 
                   
                   
                 −0.14 
                 −0.21 
                 −0.34 
                 −0.37 
                 0.29 
                   
                   
                 0 
                 0 
                 −0.04 
                 −0.11 
                 −0.11 
                   
                   
               
               
                 16 
                 0.85 
                 0.85 
                 0.97 
                 1.15 
                 1.55 
                   
                   
                 −0.15 
                 −0.3 
                 −0.33 
                 −0.18 
                 0.37 
                   
                   
                 0 
                 0 
                 −0.03 
                 −0.03 
                 −0.03 
                   
                   
               
               
                 17 
                 0.87 
                 0.87 
                 0.92 
                 0.95 
                 1.66 
                   
                   
                 −0.13 
                 −0.26 
                 −0.34 
                 −0.39 
                 0.27 
                   
                   
                 0 
                 0 
                 −0.04 
                 −0.13 
                 −0.13 
                   
                   
               
               
                 18 
                 0.87 
                 0.93 
                 0.94 
                 1.05 
                 1.61 
                   
                   
                 −0.13 
                 −0.2 
                 −0.26 
                 −0.21 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 19 
                 0.85 
                 0.93 
                 0.85 
                 1.01 
                 1.63 
                   
                   
                 −0.15 
                 −0.22 
                 −0.37 
                 −0.36 
                 0.27 
                   
                   
                 0 
                 0 
                 −0.07 
                 −0.13 
                 −0.13 
                   
                   
               
               
                 20 
                 0.87 
                 0.9 
                 1.05 
                 1.05 
                 1.53 
                   
                   
                 −0.13 
                 −0.23 
                 −0.18 
                 −0.13 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 AVE 
                 0.86 
                 0.89 
                 0.97 
                 1.04 
                 1.60 
                   
                   
                 −0.14 
                 −0.25 
                 −0.28 
                 −0.24 
                 0.36 
                   
                   
                 0.00 
                 0.00 
                 −0.02 
                 −0.04 
                 −0.04 
                   
                   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 5 x 2 Liter CCPD Therapy with Negative UF Limit Set to 25% 
               
               
                 Patient B 
               
            
           
           
               
               
               
               
            
               
                   
                 DV/FV 
                 UF/FV 
                 Unused Fluid/FV 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Day 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1 
                 0.87 
                 0.93 
                 1.03 
                 0.97 
                 1.6 
                   
                   
                 −0.13 
                 −0.2 
                 −0.17 
                 −0.2 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 2 
                 0.86 
                 0.88 
                 1 
                 1.1 
                 1.54 
                   
                   
                 −0.14 
                 −0.26  
                 −0.26 
                 −0.16 
                 0.38 
                   
                   
                 0 
                 −0.01 
                 −0.02 
                 −0.02 
                 −0.02 
                   
                   
               
               
                 3 
                 0.87 
                 0.89 
                 0.91 
                 1.1 
                 1.55 
                   
                   
                 −0.13 
                 −0.24  
                 −0.33 
                 −0.23 
                 0.32 
                   
                   
                 0 
                 0 
                 −0.08 
                 −0.08 
                 −0.08 
                   
                   
               
               
                 4 
                 0.87 
                 0.93 
                 0.97 
                 0.87 
                 1.65 
                   
                   
                 −0.13 
                 −0.2 
                 −0.23 
                 −0.36 
                 0.29 
                   
                   
                 0 
                 0 
                 0 
                 −0.11 
                 −0.11 
                   
                   
               
               
                 5 
                 0.86 
                 0.89 
                 1 
                 1.01 
                 1.64 
                   
                   
                 −0.14 
                 −0.25  
                 −0.25 
                 −0.24 
                 0.40 
                   
                   
                 0 
                 0 
                 0 
                 0 
                 0 
                   
                   
               
               
                 6 
                 0.87 
                 0.92 
                 0.88 
                 0.88 
                 1.57 
                   
                   
                 −0.13 
                 −0.21  
                 −0.33 
                 −0.45 
                 0.12 
                   
                   
                 0 
                 0 
                 −0.08 
                 −0.28 
                 −0.28 
                   
                   
               
               
                 7 
                 0.86 
                 0.87 
                 0.93 
                 0.94 
                 1.54 
                   
                   
                 −0.14 
                 −0.27  
                 −0.34 
                 −0.4 
                 0.14 
                   
                   
                 0 
                 −0.02 
                 −0.11 
                 −0.26 
                 −0.26 
                   
                   
               
               
                 8 
                 0.86 
                 0.93 
                 0.89 
                 1.09 
                 1.56 
                   
                   
                 −0.14 
                 −0.21  
                 −0.32 
                 −0.23 
                 0.33 
                   
                   
                 0 
                 0 
                 −0.07 
                 −0.07 
                 −0.07 
                   
                   
               
               
                 9 
                 0.87 
                 0.87 
                 0.91 
                 0.89 
                 1.54 
                   
                   
                 −0.13 
                 −0.26  
                 −0.35 
                 −0.46 
                 0.08 
                   
                   
                 0 
                 −0.01 
                 −0.11 
                 −0.32 
                 −0.32 
                   
                   
               
               
                 10 
                 0.85 
                 0.85 
                 1.04 
                 0.94 
                 1.69 
                   
                   
                 −0.15 
                 −0.3 
                 −0.26 
                 −0.32 
                 0.27 
                   
                   
                 0 
                 −0.05 
                 −0.06 
                 −0.13 
                 −0.13 
                   
                   
               
               
                 11 
                 0.85 
                 0.86 
                 0.91 
                 1.14 
                 1.47 
                   
                   
                 −0.15 
                 −0.29  
                 −0.38 
                 −0.24 
                 0.23 
                   
                   
                 0 
                 −0.04 
                 −0.17 
                 −0.17 
                 −0.17 
                   
                   
               
               
                 12 
                 0.87 
                 0.86 
                 0.88 
                 0.87 
                 1.49 
                   
                   
                 −0.13 
                 −0.27  
                 −0.39 
                 −0.52 
                 −0.03 
                   
                   
                 0 
                 −0.02 
                 −0.16 
                 −0.43 
                 −0.43 
                   
                   
               
               
                 13 
                 0.86 
                 0.9 
                 0.94 
                 1.06 
                 1.59 
                   
                   
                 −0.14 
                 −0.24 
                 −0.3 
                 −0.24 
                 0.35 
                   
                   
                 0 
                 0 
                 −0.05 
                 −0.05 
                 −0.05 
                   
                   
               
               
                 14 
                 0.85 
                 0.92 
                 0.87 
                 1.14 
                 1.51 
                   
                   
                 −0.15 
                 −0.23  
                 −0.36 
                 −0.22 
                 0.29 
                   
                   
                 0 
                 0 
                 −0.11 
                 −0.11 
                 −0.11 
                   
                   
               
               
                 15 
                 0.87 
                 0.88 
                 0.87 
                 0.98 
                 1.52 
                   
                   
                 −0.13 
                 −0.25  
                 −0.38 
                 −0.4 
                 0.12 
                   
                   
                 0 
                 0 
                 −0.13 
                 −0.28 
                 −0.28 
                   
                   
               
               
                 16 
                 0.87 
                 0.92 
                 0.91 
                 0.9 
                 1.6 
                   
                   
                 −0.13 
                 −0.21 
                 −0.3 
                 −0.4 
                 0.20 
                   
                   
                 0 
                 0 
                 −0.05 
                 −0.2 
                 −0.2 
                   
                   
               
               
                 17 
                 0.87 
                 0.86 
                 1.04 
                 1.14 
                 1.47 
                   
                   
                 −0.13 
                 −0.27  
                 −0.23 
                 −0.09 
                 0.38 
                   
                   
                 0 
                 −0.02 
                 −0.02 
                 −0.02 
                 −0.02 
                   
                   
               
               
                 18 
                 0.86 
                 0.89 
                 0.98 
                 1.04 
                 1.61 
                   
                   
                 −0.14 
                 −0.25  
                 −0.27 
                 −0.23 
                 0.38 
                   
                   
                 0 
                 0 
                 −0.02 
                 −0.02 
                 −0.02 
                   
                   
               
               
                 19 
                 0.85 
                 0.85 
                 0.88 
                 1.1 
                 1.43 
                   
                   
                 −0.15 
                 −0.3 
                 −0.42 
                 −0.32 
                 0.11 
                   
                   
                 0 
                 −0.05 
                 −0.22 
                 −0.29 
                 −0.29 
                   
                   
               
               
                 20 
                 0.87 
                 0.85 
                 1.05 
                 1.07 
                 1.53 
                   
                   
                 −0.13 
                 −0.28  
                 −0.23 
                 −0.16 
                 0.37 
                   
                   
                 0 
                 −0.03 
                 −0.03 
                 −0.03 
                 −0.03 
                   
                   
               
               
                 AVE 
                 0.86 
                 0.89 
                 0.94 
                 1.01 
                 1.55 
                   
                   
                 −0.14 
                 −0.25  
                 −0.31 
                 −0.29 
                 0.26 
                   
                   
                 0.00 
                 −0.01 
                 −0.07 
                 −0.14 
                 −0.14 
                   
                   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 8 
               
             
            
               
                   
               
               
                 5 x 2 Liter CCPD Therapy with Negative UF Limit Set to 20% 
               
               
                 Patient B 
               
            
           
           
               
               
               
               
            
               
                   
                 DV/FV 
                 UF/FV 
                 Unused Fluid/FV 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Day 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1 
                 0.85 
                 0.85 
                 0.92 
                 0.97 
                 1.32 
                   
                   
                 −0.15 
                 −0.3 
                 −0.38 
                 −0.41 
                 −0.09 
                   
                   
                 0 
                 −0.1 
                 −0.28 
                 −0.49 
                 −0.49 
                   
                   
               
               
                 2 
                 0.85 
                 0.89 
                 1.03 
                 0.93 
                 1.51 
                   
                   
                 −0.15 
                 −0.26 
                 −0.23 
                 −0.3 
                 0.21 
                   
                   
                 0 
                 −0.06 
                 −0.09 
                 −0.19 
                 −0.19 
                   
                   
               
               
                 3 
                 0.87 
                 0.91 
                 0.92 
                 1.1 
                 1.48 
                   
                   
                 −0.13 
                 −0.22 
                 −0.3 
                 −0.2 
                 0.28 
                   
                   
                 0 
                 −0.02 
                 −0.12 
                 −0.12 
                 −0.12 
                   
                   
               
               
                 4 
                 0.85 
                 0.9 
                 1.02 
                 0.87 
                 1.52 
                   
                   
                 −0.15 
                 −0.25 
                 −0.23 
                 −0.36 
                 0.16 
                   
                   
                 0 
                 −0.05 
                 −0.08 
                 −0.24 
                 −0.24 
                   
                   
               
               
                 5 
                 0.87 
                 0.86 
                 0.97 
                 0.94 
                 1.43 
                   
                   
                 −0.13 
                 −0.27 
                 −0.3 
                 −0.36 
                 0.07 
                   
                   
                 0 
                 −0.07 
                 −0.17 
                 −0.33 
                 −0.33 
                   
                   
               
               
                 6 
                 0.87 
                 0.89 
                 0.89 
                 0.91 
                 1.41 
                   
                   
                 −0.13 
                 −0.24 
                 −0.35 
                 −0.44 
                 −0.03 
                   
                   
                 0 
                 −0.04 
                 −0.19 
                 −0.43 
                 −0.43 
                   
                   
               
               
                 7 
                 0.86 
                 0.92 
                 0.99 
                 1.04 
                 1.54 
                   
                   
                 −0.14 
                 −0.22 
                 −0.23 
                 −0.19 
                 0.35 
                   
                   
                 0 
                 −0.02 
                 −0.05 
                 −0.05 
                 −0.05 
                   
                   
               
               
                 8 
                 0.85 
                 0.86 
                 0.97 
                 1.14 
                 1.37 
                   
                   
                 −0.15 
                 −0.29 
                 −0.32 
                 −0.18 
                 0.19 
                   
                   
                 0 
                 −0.09 
                 −0.21 
                 −0.21 
                 −0.21 
                   
                   
               
               
                 9 
                 0.87 
                 0.93 
                 0.88 
                 0.91 
                 1.48 
                   
                   
                 −0.13 
                 −0.2 
                 −0.32 
                 −0.41 
                 0.07 
                   
                   
                 0 
                 0 
                 −0.12 
                 −0.33 
                 −0.33 
                   
                   
               
               
                 10 
                 0.86 
                 0.85 
                 0.92 
                 0.92 
                 1.34 
                   
                   
                 −0.14 
                 −0.29 
                 −0.37 
                 −0.45 
                 −0.11 
                   
                   
                 0 
                 −0.09 
                 −0.26 
                 −0.51 
                 −0.51 
                   
                   
               
               
                 11 
                 0.85 
                 0.89 
                 0.91 
                 0.85 
                 1.39 
                   
                   
                 −0.15 
                 −0.26 
                 −0.35 
                 −0.5 
                 −0.11 
                   
                   
                 0 
                 −0.06 
                 −0.21 
                 −0.51 
                 −0.51 
                   
                   
               
               
                 12 
                 0.86 
                 0.92 
                 0.87 
                 1.14 
                 1.43 
                   
                   
                 −0.14 
                 −0.22 
                 −0.35 
                 −0.21 
                 0.22 
                   
                   
                 0 
                 −0.02 
                 −0.17 
                 −0.18 
                 −0.18 
                   
                   
               
               
                 13 
                 0.85 
                 0.87 
                 0.9 
                 1.01 
                 1.34 
                   
                   
                 −0.15 
                 −0.28 
                 −0.38 
                 −0.37 
                 −0.03 
                   
                   
                 0 
                 −0.08 
                 −0.26 
                 −0.43 
                 −0.43 
                   
                   
               
               
                 14 
                 0.85 
                 0.89 
                 0.98 
                 0.97 
                 1.46 
                   
                   
                 −0.15 
                 −0.26 
                 −0.28 
                 −0.31 
                 0.15 
                   
                   
                 0 
                 −0.06 
                 −0.14 
                 −0.25 
                 −0.25 
                   
                   
               
               
                 15 
                 0.87 
                 0.9 
                 1 
                 0.93 
                 1.54 
                   
                   
                 −0.13 
                 −0.23 
                 −0.23 
                 −0.3 
                 0.24 
                   
                   
                 0 
                 −0.03 
                 −0.06 
                 −0.16 
                 −0.16 
                   
                   
               
               
                 16 
                 0.87 
                 0.85 
                 0.86 
                 0.94 
                 1.3 
                   
                   
                 −0.13 
                 −0.28 
                 −0.42 
                 −0.48 
                 −0.18 
                   
                   
                 0 
                 −0.08 
                 −0.3 
                 −0.58 
                 −0.58 
                   
                   
               
               
                 17 
                 0.87 
                 0.9 
                 1.01 
                 0.95 
                 1.55 
                   
                   
                 −0.13 
                 −0.23 
                 −0.22 
                 −0.27 
                 0.28 
                   
                   
                 0 
                 −0.03 
                 −0.05 
                 −0.12 
                 −0.12 
                   
                   
               
               
                 18 
                 0.87 
                 0.88 
                 0.86 
                 1.07 
                 1.36 
                   
                   
                 −0.13 
                 −0.25 
                 −0.39 
                 −0.32 
                 0.04 
                   
                   
                 0 
                 −0.05 
                 −0.24 
                 −0.36 
                 −0.36 
                   
                   
               
               
                 19 
                 0.86 
                 0.93 
                 1 
                 1.12 
                 1.47 
                   
                   
                 −0.14 
                 −0.21 
                 −0.21 
                 −0.09 
                 0.38 
                   
                   
                 0 
                 −0.01 
                 −0.02 
                 −0.02 
                 −0.02 
                   
                   
               
               
                 20 
                 0.87 
                 0.85 
                 0.96 
                 0.94 
                 1.4 
                   
                   
                 −0.13 
                 −0.28 
                 −0.32 
                 −0.38 
                 0.02 
                   
                   
                 0 
                 −0.08 
                 −0.2 
                 −0.38 
                 −0.38 
                   
                   
               
               
                 AVE 
                 0.86 
                 0.89 
                 0.94 
                 0.98 
                 1.43 
                   
                   
                 −0.14 
                 −0.25 
                 −0.31 
                 −0.33 
                 0.11 
                   
                   
                 0.00 
                 −0.05 
                 −0.16 
                 −0.29 
                 −0.29 
                   
                   
               
               
                   
               
            
           
         
       
     
     With the negative UF Limit set at 20%, neither Patient A nor Patient B encounters a drain/fill volume ratio that exceeds 1.6 during the course of the twenty therapies comprising data contained in Tables 4 and 8, each therapy including five cycles. The unused fluid/fill volume ratio with the 20% negative UF limit in Tables 4 and 8 averages 25% and 29%, which means that 25% and 29% of 2000 ml (500 ml to 580 ml) of dialysis solution is unused. Thus, system  10 , using the negative UF limit to determine when to short fill volumes without increasing the number of cycles, would reduce the effectiveness of the 10,000 ml therapy by around 5% (500/10,000=5%, to 580/10,000=5.8%). 
     Referring now to  FIG. 11C , flow diagram  200  illustrates one embodiment of a system  10  in which CCPD therapy is intended and begun. In this embodiment, the therapy may be switched to tidal therapy if the drains are incomplete or if too much dialysis fluid is not being used. The method begins at oval  202 . At block  204 , the system  10  performs an initial drain, followed by block  206  with a fill. Per block  260 , for drains after the initial drain, a shorter fill volume will be used, i.e., the fill is shorted, if the previous drain falls short of the target volume and the UF limit is exceeded. The user sets a programmable negative UF limit, such as 40% negative UF, that is used to determine when to use shorter fill volumes after one or more incomplete drains when running a CCPD therapy, or if a switch has been made, when running a Tidal therapy. Other limits may be used, as mentioned above for the processes of  FIGS. 11A and 11B . 
     After the fill, a dwell at block  208  is performed, the dwell calculated as previously discussed. After the dwell, a drain is performed at block  210 . Based on the drain, the ratio of the drain volume to fill volume is calculated, and the ratio for the last twenty drains is calculated and stored at block  212 . At diamond  214 , the system questions whether a short fill was enabled for the previous cycle. If not, the ratio for the previous twenty cycles is compared to determine whether any of the cycles had a ratio greater than 1.9 at diamond  220 . If not, the process continues to block  226  where the number of remaining cycles and the dwell time is calculated. If any of the previous twenty cycles had a ratio greater than 1.9, then the process enables short fills at the set limit for negative UF, such as 40% UF, at block  222 , and then proceeds to block  224 . 
     Returning to diamond  214 , if a short fill was enabled for a previous cycle, the process continues to diamond  216 . At this point, the ratios are analyzed to determine whether the ratio exceeded 1.6 for five of the twenty previous cycles. Other embodiments may use other benchmarks than five of the previous twenty cycles, for example, four or six of the previous ten cycles. If yes, the negative UF limit may be reset or lowered 10% and the process continued to block  224 . If not, the process also continues to block  224 . At block  224 , the patient fill volume is reset to the negative UF limit minus the accumulated negative UF. For all the eventualities from blocks  222  and  224 , and diamonds  214 ,  216  and  220 , the next step is block  226 , at which the remaining number of cycles and the dwell time for each is calculated. 
     For CCPD therapies, system  10  calculates the remaining number of CCPD cycles using the equation: Cycles Remaining=(total remaining therapy volume−last fill volume (if any))/(programmed fill volume). For Tidal therapies after an incomplete tidal drain, or after a complete full drain, system  10  calculates the remaining number of tidal cycles using the equation: Cycles Remaining=1+(Remaining Therapy Volume−Fill Volume−Last Fill Volume)/(Tidal PerCent*Fill Volume). For Tidal therapies after a complete tidal drain, system  10  calculates the remaining number of tidal cycles using the equation: Cycles Remaining=(Remaining Therapy Volume−Last Fill Volume)/(Tidal PerCent*Fill Volume). 
     At diamond  228  if the fractional number of cycles exceeds 0.85, the number of cycles is rounded up to the nearest integer, per block  230 . At diamond  232 , system  10  compares the number of remaining cycles to zero. If the number of cycles remaining is greater than zero, the next fill is performed, per block  206  and the process is repeated. If the number of cycles is zero, the decision tree proceeds to diamond  234 . If no additional cycles were required in ten or more of the previous twenty therapies, the therapy is complete, per block  240 . If additional cycles were required in ten or more of the previous twenty therapies, diamond  236  asks whether the current therapy is tidal (not CCPD). If the current therapy is tidal and is not CCPD, a recommendation is made for the next therapy to reduce the tidal volume by 10% in block  242 . Therapy is adjudged complete for this particular therapy at block  240 . Returning to block  236 , if the patient is presently using CCPD therapy, and additional cycles were required in ten or more (half of more) of the previous twenty therapies, a switch to 75% tidal therapy is recommended for the next therapy, after which the present therapy is complete. 
     Returning to diamond  228 , if the fractional number of cycles is less than 0.85, the process moves to diamond  244 , and the number of fractional cycles is compared to 0.40. If the fractional number of cycles is less than 0.40, the remaining number of cycles is truncated at block  258  and the truncated or rounded down number of cycles is compared to zero at block  232 . If the number of remaining cycles is zero, the process follows the decision tree discussed above for diamond  234 . If the number of remaining cycles is an integer of 1 or more, the next fill is performed, per block  206 . 
     Returning to diamond  244 , if the fractional cycle remaining exceeds 0.4, a truncated number or rounded down number of cycles is used to calculate an increased fill volume at block  246 . At block  248 , the increased fill volume based on the lower number of cycles is compared with the fill volume based on the present prescription. The fill volume is calculated to use the total therapy volume in the rounded down or truncated number of cycles. The volumes are calculated as follows: 
       higher fill volume=(remaining therapy volume−last fill volume)/rounded down number of cycles.
 
     If the ratio of the increased fill volume to prescribed fill volume based on the lower number cycles is less than 1.05 (i.e., the increase is less than 5%), as seen at diamond  248 , system  10  resets the fill volume for the next fill to the calculated increased fill volume at block  250 . The system then uses the truncated number of cycles, per block  258 , and returns through comparison diamond  232  to the next fill at block  206  or the decision tree at block  234 . The ratio at block  248  may be greater than 1.05, reflecting a significant increase in the fill volume of the next cycle compared with the most recent. In order to avoid such abrupt changes, the system  10  at block  252  then rounds up the previously-truncated number of cycles (from block  246 ) and then calculates a decreased fill volume using the higher number of cycles. The calculation used is: 
       lower fill volume=(remaining therapy volume−last fill volume)/rounded up number of cycles.
 
     The system  10  then uses this rounded-up number and a decreased fill volume at block  254  for the next cycle. This decreased fill volume is noted and is tracked at block  256  as an added cycle. The added cycle is noted in comparison diamond  234 . 
     Example for Patient C, per Table 9 and  FIG. 11C : The negative UF limit may be combined with the Unused fluid volume limit to better control the operation of system  10 , as seen in  FIG. 11C . Table 9 contains four sub-tables, three similar to the others discussed above, and a fourth sub-table that depicts the actual fill volume/programmed fill volume (Actual FV/Programmed FV). This fourth sub-table demonstrates that the increased fill volume due to incomplete drains, in this case, does not exceed 20% of the programmed fill volume, as was the case above in the Example for Patient A and Patient B. However, in this case, a cycle is added any time the Unused Fluid/Fill Volume ratio in any of columns 3 through 5 goes more negative than −0.40. In fifteen of the 20 therapies all of the available fluid is used (see column 6, “0” unused fluid/FV ratio). 
     
       
         
           
               
             
               
                 TABLE 9 
               
             
            
               
                   
               
               
                 5 x 2 Therapy Changes to 2 x 2 + 3 shorted + 1 with new fill volume (remainder of fluid) 
               
               
                 CCPD Therapy with Negative UFLimit Set to 20% 
               
            
           
           
               
               
            
               
                   
                 Patient C 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Day 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 DV/FV 
                 UF/FV 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1 
                 0.86 
                 0.87 
                 0.85 
                 0.9 
                 0.96 
                 1.59 
                 −0.14 
                 −0.27 
                 −0.42 
                 −0.52 
                 −0.56 
                 0.03 
               
               
                 2 
                 0.86 
                 0.87 
                 0.94 
                 0.94 
                 1.4 
                   
                 −0.14 
                 −0.27 
                 −0.33 
                 −0.39 
                 0.01 
                   
               
               
                 3 
                 0.85 
                 0.87 
                 0.94 
                 0.93 
                 1.38 
                 1.4 
                 −0.15 
                 −0.28 
                 −0.34 
                 −0.41 
                 −0.03 
                 0.37 
               
               
                 4 
                 0.85 
                 0.85 
                 0.86 
                 0.9 
                 0.91 
                 1.67 
                 −0.15 
                 −0.3 
                 −0.44 
                 −0.54 
                 −0.63 
                 0.04 
               
               
                 5 
                 0.85 
                 0.87 
                 0.87 
                 1 
                 1.31 
                 1.3 
                 −0.15 
                 −0.28 
                 −0.41 
                 −0.41 
                 −0.1 
                 0.20 
               
               
                 6 
                 0.87 
                 0.87 
                 0.95 
                 0.93 
                 1.43 
                   
                 −0.13 
                 −0.26 
                 −0.31 
                 −0.38 
                 0.05 
                   
               
               
                 7 
                 0.87 
                 0.87 
                 0.91 
                 1.01 
                 1.39 
                   
                 −0.13 
                 −0.26 
                 −0.35 
                 −0.34 
                 0.05 
                   
               
               
                 8 
                 0.86 
                 0.86 
                 0.95 
                 0.91 
                 1.39 
                 1.4 
                 −0.14 
                 −0.28 
                 −0.33 
                 −0.42 
                 −0.03 
                 0.37 
               
               
                 9 
                 0.85 
                 0.86 
                 0.85 
                 0.93 
                 1.05 
                 1.5 
                 −0.15 
                 −0.29 
                 −0.44 
                 −0.51 
                 −0.46 
                 0.04 
               
               
                 10 
                 0.85 
                 0.85 
                 0.91 
                 0.91 
                 0.99 
                 1.6 
                 −0.15 
                 −0.3 
                 −0.39 
                 −0.48 
                 −0.49 
                 0.11 
               
               
                 11 
                 0.87 
                 0.85 
                 0.94 
                 1 
                 1.38 
                   
                 −0.13 
                 −0.28 
                 −0.34 
                 −0.34 
                 0.04 
                   
               
               
                 12 
                 0.87 
                 0.86 
                 0.86 
                 0.92 
                 0.92 
                 1.62 
                 −0.13 
                 −0.27 
                 −0.41 
                 −0.49 
                 −0.57 
                 0.05 
               
               
                 13 
                 0.85 
                 0.87 
                 0.86 
                 1.03 
                 1.3 
                 1.5 
                 −0.15 
                 −0.28 
                 −0.42 
                 −0.39 
                 −0.09 
                 0.41 
               
               
                 14 
                 0.85 
                 0.85 
                 0.88 
                 1.04 
                 1.28 
                 1.45 
                 −0.15 
                 −0.3 
                 −0.42 
                 −0.38 
                 −0.1 
                 0.35 
               
               
                 15 
                 0.85 
                 0.87 
                 0.88 
                 0.9 
                 0.9 
                 1.63 
                 −0.15 
                 −0.28 
                 −0.4 
                 −0.5 
                 −0.6 
                 0.03 
               
               
                 16 
                 0.87 
                 0.86 
                 0.88 
                 1.01 
                 1.34 
                 1.3 
                 −0.13 
                 −0.27 
                 −0.39 
                 −0.38 
                 −0.04 
                 0.26 
               
               
                 17 
                 0.85 
                 0.85 
                 0.94 
                 0.92 
                 1.34 
                 1.45 
                 −0.15 
                 −0.3 
                 −0.36 
                 −0.44 
                 −0.1 
                 0.35 
               
               
                 18 
                 0.86 
                 0.86 
                 0.88 
                 0.85 
                 0.9 
                 1.7 
                 −0.14 
                 −0.28 
                 −0.4 
                 −0.55 
                 −0.65 
                 0.05 
               
               
                 19 
                 0.87 
                 0.86 
                 0.86 
                 1.05 
                 1.32 
                 1.36 
                 −0.13 
                 −0.27 
                 −0.41 
                 −0.36 
                 −0.04 
                 0.32 
               
               
                 20 
                 0.87 
                 0.87 
                 0.89 
                 1 
                 1.37 
                   
                 −0.13 
                 −0.26 
                 −0.37 
                 −0.37 
                 0 
                   
               
               
                 AVE 
                 0.86 
                 0.89 
                 1.00 
                 1.37 
                 1.21 
                 1.50 
                 −0.14 
                 −0.28 
                 −0.38 
                 −0.43 
                 −0.22 
                 0.28 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Unused Fluid/FV 
                 Actual FV/Programmed FV 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1 
                 0 
                 0 
                 −0.07 
                 −0.29 
                 −0.61 
                 0 
                 1.00 
                 1.14 
                 1.20 
                 1.20 
                 0.81 
                 0.81 
               
               
                 2 
                 0 
                 0 
                 −0.07 
                 −0.2 
                 −0.39 
                   
                 1.00 
                 1.14 
                 1.20 
                 1.20 
                 1.20 
                 1.20 
               
               
                 3 
                 0 
                 0 
                 −0.08 
                 −0.22 
                 −0.43 
                 0 
                 1.00 
                 1.15 
                 1.20 
                 1.20 
                 0.72 
                 0.72 
               
               
                 4 
                 0 
                 0 
                 −0.1 
                 −0.34 
                 −0.68 
                 0 
                 1.00 
                 1.15 
                 1.20 
                 1.20 
                 0.84 
                 0.84 
               
               
                 5 
                 0 
                 0 
                 −0.08 
                 −0.29 
                 −0.5 
                 0 
                 1.00 
                 1.15 
                 1.20 
                 1.20 
                 0.75 
                 0.75 
               
               
                 6 
                 0 
                 0 
                 −0.06 
                 −0.17 
                 −0.35 
                   
                 1.00 
                 1.13 
                 1.20 
                 1.20 
                 1.20 
                 1.20 
               
               
                 7 
                 0 
                 0 
                 −0.06 
                 −0.21 
                 −0.35 
                   
                 1.00 
                 1.13 
                 1.20 
                 1.20 
                 1.20 
                 1.20 
               
               
                 8 
                 0 
                 0 
                 −0.08 
                 −0.21 
                 −0.43 
                 0 
                 1.00 
                 1.14 
                 1.20 
                 1.20 
                 0.72 
                 0.72 
               
               
                 9 
                 0 
                 0 
                 −0.09 
                 −0.33 
                 −0.64 
                 0 
                 1.00 
                 1.15 
                 1.20 
                 1.20 
                 0.82 
                 0.82 
               
               
                 10 
                 0 
                 0 
                 −0.1 
                 −0.29 
                 −0.57 
                 0 
                 1.00 
                 1.15 
                 1.20 
                 1.20 
                 0.79 
                 0.79 
               
               
                 11 
                 0 
                 0 
                 −0.08 
                 −0.22 
                 −0.36 
                   
                 1.00 
                 1.13 
                 1.20 
                 1.20 
                 1.20 
                 1.20 
               
               
                 12 
                 0 
                 0 
                 −0.07 
                 −0.28 
                 −0.57 
                 0 
                 1.00 
                 1.13 
                 1.20 
                 1.20 
                 0.79 
                 0.79 
               
               
                 13 
                 0 
                 0 
                 −0.08 
                 −0.3 
                 −0.49 
                 0 
                 1.00 
                 1.15 
                 1.20 
                 1.20 
                 0.75 
                 0.75 
               
               
                 14 
                 0 
                 0 
                 −0.1 
                 −0.32 
                 −0.5 
                 0 
                 1.00 
                 1.15 
                 1.20 
                 1.20 
                 0.75 
                 0.75 
               
               
                 15 
                 0 
                 0 
                 −0.08 
                 −0.28 
                 −0.58 
                 0 
                 1.00 
                 1.15 
                 1.20 
                 1.20 
                 0.79 
                 0.79 
               
               
                 16 
                 0 
                 0 
                 −0.07 
                 −0.26 
                 −0.44 
                 0 
                 1.00 
                 1.13 
                 1.20 
                 1.20 
                 0.72 
                 0.72 
               
               
                 17 
                 0 
                 0 
                 −0.1 
                 −0.26 
                 −0.5 
                 0 
                 1.00 
                 1.15 
                 1.20 
                 1.20 
                 0.75 
                 0.75 
               
               
                 18 
                 0 
                 0 
                 −0.08 
                 −0.28 
                 −0.63 
                 0 
                 1.00 
                 1.14 
                 1.20 
                 1.20 
                 0.82 
                 0.82 
               
               
                 19 
                 0 
                 0 
                 −0.07 
                 −0.28 
                 −0.44 
                 0 
                 1.00 
                 1.13 
                 1.20 
                 1.20 
                 0.72 
                 0.72 
               
               
                 20 
                 0 
                 0 
                 −0.06 
                 −0.23 
                 −0.4 
                   
                 1.00 
                 1.13 
                 1.20 
                 1.20 
                 1.20 
                 1.20 
               
               
                 AVE 
                 0.00 
                 0.00 
                 −0.08 
                 −0.26 
                 −0.49 
                 0.00 
                 1.00 
                 1.14 
                 1.20 
                 1.20 
                 0.88 
                 0.88 
               
               
                   
               
            
           
         
       
     
     At the present time in 2008, most APD patients perform CCPD therapies and there is no UF limit that results in an automatic shorting of the next fill when a drain is not complete. Succeeding fills are always full if the minimum drain volume was achieved during the previous drain. A negative UF alarm is sounded if the accumulation of negative UF exceeds an alarm limit, typically set at 50% of the programmed fill volume. The tracking of negative UF is based solely upon the volume drained less the volume filled and does not account for ultra-filtration across the peritoneal membrane. The method described herein tracks the ratio of the volume drained to the prescribed fill volume. Per the discussion above for  FIG. 11C , if this ratio exceeds 1.9 once in every twenty drains, or if the ratio exceeds 1.6 five times in every twenty drains, the system will suggest that the user Enable the negative UF limit algorithm to limit fill volumes and add cycles as necessary to reduce the magnitude and incidence of increased intra-peritoneal volume. 
       FIG. 11C  illustrates how the system monitors CCPD drain ratios and uses the results to suggest when the user should enable the negative UF limit algorithm to limit IIPV. The system will lower the UF threshold for shorting fills to limit the incidence of IIPV and low drain alarms. The system will also suggest when the user should switch to a tidal therapy. 
     As described above for block  220 , system  10  suggests activating the negative UF limit algorithm if a drain volume/fill volume ratio exceeds 1.9 during any of the Drains 2 through N drains (the last drain) in more than one per twenty therapies. 
     At block  216 , system  10  suggests lowering the negative UF limit setting if a drain/fill volume exceeds 1.6 during the first drain through N drains (the last drain) more than x occurrences in y therapies, e.g., more than five times in twenty therapies. Other embodiments may use other limits, for the drain volume/fill volume ratio, for the number of therapies in which a particular high ratio is encountered, or for both. 
     At diamond  220 , system  10  monitors the drain to fill volume ratio and also monitors the unused fluid/fill volume (FV) ratio and determines whether the unused fluid/FV exceeds a certain ratio in a number of cycles in a given therapy. For example, system  10  may set 40% (a ratio of 0.40) in any of cycles 2 through N−2 of N (that is, the second-next-to last, e.g., cycles 2-3 in a five-cycle therapy or cycles 2-4 in a six-cycle therapy). In another example, the system may use 50% (a ratio of 0.50) in cycles 2 through N−1 (next to last), e.g., cycles 2-4 in a five-cycle therapy or cycles 2-5 in a six-cycle therapy, for which an example is given in Table 9. Note that in Table 9, the UF/FV ratio for day 1 at cycle 2 is −0.27, which exceeds the negative 20% limit that was used when generating Table 9. Thus, the next cycle is shorted by 7%, leading to an Unused Fluid/FV for day 1, cycle 3, of −0.07. At cycle 3, the UF/FV ratio rises to −0.42, i.e., again negative UF. Cycle 4 is now shorted 29% (−0.29=−0.07−0.22 for Unused Fluid/FV at day 1, cycle 4, since −0.42−(−0.20)=−0.22). The result of Cycle 4 is still negative UF (−0.52) and cycle 5 is again shorted (−0.61 Unused Fluid/FV). Since 0.61 exceeds 0.50 (50%), the number of cycles is increased by 1 (adding a sixth cycle) and the target patient fill volume is decreased, so that the remainder of the dialysis fluid is used in the sixth cycle. 
     At block  254 , using the 50% example and if unused fluid/FV exceeds 50%, system  10  increases the remaining number of cycles by 1 and distributes the remaining dwell time and remaining therapy volume evenly over the increased remaining number of cycles (see, e.g., in Table 9, day 1, number of cycles increased to six when the unused fluid/FV ratio exceeds 0.50 (actually 0.61) in the column for cycle 4. At blocks  228  and  244  after the next fill cycle, system  10  calculates the unused Fluid/FV ratio (remaining cycler fraction) to zero for a therapy with a cycle added. 
     Returning to diamond  244 , if the unused fluid/FV ratio is less than 40%, the system instead moves to diamond  258  and eventually to diamond  234  when all of the available fluid has been delivered. At diamond  234 , system  10  monitors the frequency at which an increased number of cycles is needed to prevent fluid loss in excess of a given percentage A (e.g., 50%) of the fill volume. If the frequency is equal to or greater than 50% of the time (e.g., ten times or more over twenty therapies), system  10  at block  236  suggests that the patient be converted to a tidal therapy since the patient is already in effect performing an 85% tidal therapy. For example, switching to a 75% tidal therapy may be a more effective use of the fluid volume that is available while minimizing the magnitude of excess intra-peritoneal volume and reducing the frequency of low drain volume alarms. 
     At block  256 , system  10  uses UF trending discussed below to monitor the 75% (or current) tidal therapy. At diamond  234 , system  10  determines whether the frequency at which the patient&#39;s residual volume has to be offset over time is greater than a specified percentage of the time, e.g., 50% percent of the time. If so, system  10  suggests switching to a lower percentage, e.g., 65%, tidal therapy at block  242  for the next therapy. If the residual volume still has to be offset greater than a certain percentage, e.g., 50%, of the time, as determined at diamond  234 , the loop continues to lower the tidal percentage until the residual drain volume is lowered to an acceptable level, at which time the method of logic flow diagram  200  ends. Tidal therapies are still effective with regard to solute removal for tidal percentages as low as about 50%. Ultra-filtration can be maintained at tidal percentages lower than 50%. 
     If a patient still has drain issues with a tidal percentage of around 50%, the patient is a candidate for multi-pass continuous flow peritoneal dialysis (Multi-Pass CFPD) as discussed in US Pat. Appl. Publ. 20040019320, which is hereby incorporated herein by reference. Multi-Pass CFPD continuously fills and drains the patient using either a dual lumen catheter as discussed in US Pat. Appl. Publ. 20030204162 and U.S. Pat. No. 6,976,973, both of which are hereby incorporated herein by reference. Alternatively, two single lumen catheters may be used. The patient is only drained to below the prescribed fill volume prior to the start of the Multi-Pass CFPD therapy and at the end of the Multi-Pass CFPD therapy. Low drain volume alarms are virtually eliminated. Check Patient line alarms can still occur if the patient line becomes kinked. 
     Optimizing Tidal Therapies Via UF Trending 
     As discussed above, there is a need for an automated peritoneal dialysis therapy that ensures the use of all of the prescribed dialysis solution, can finish on time, can minimize if not eliminate low drain volume alarms and can prevent the volume of fluid in the patient&#39;s peritoneum from exceeding the programmed fill volume by more than about the amount of expected ultrafiltration (“UF”) obtained from the patient over one dwell cycle. Properly estimating a patient&#39;s UF for a given solution is therefore important. It is contemplated that system  10 , instead of using predicted UF values, uses recently trended UF values for the same type of treatment using the same type of PD solution. 
     Referring now to  FIG. 12 , a trend for a 50% tidal therapy with programmed UF based upon trending is shown for both 1.5% and 2.5% dextrose concentration dialysis solution types. The trended 50% therapy for the patient shows that about 2400 ml of UF is removed if that patient uses 2.5% dextrose and 1600 ml of UF is removed if that patient uses 1.5% dextrose. 
     The total UF is then divided out over the number of night therapy cycles (fills/dwells/drains) to determine the UF per cycle, e.g., four cycles resulting in 600 ml UF for 2.5% dextrose and 400 ml of UF for 1.5% dextrose. The values of 600 ml and 400 ml are added to the prescribed fill volumes to determine a patient&#39;s maximum allowable IPV in one embodiment. The maximum IPV is then used to determine the volume of residual fluid that should remain in the patient&#39;s peritoneum after a drain. For example, if the patient&#39;s maximum IPV is 2600 ml (2000 ml fill plus 600 ml UF), the residual volume for a fifty percent tidal drain should be 1300 ml. Just as important, the cycler of system  10  will attempt to remove 1300 ml over the drain. 
       FIG. 12  shows, for each dextrose level, each day&#39;s UF entry. System  10  in one embodiment determines the actual UF removed from the patient over the course of a night therapy (not counting last fill or day exchange). The actual UF measurement assumes a complete (to zero ml) drain prior to both the first fill and last or day fill (if performed). In this manner, System  10  knows how much fresh dialysate has been delivered to the patient and how much spent dialysate (including UF) has been removed from the patient over the nightly treatment. The difference is the night therapy UF, which is logged into data storage for the patient, the concentrate and therapy, and used to further update the trend. UF can be plotted as a single day ( FIG. 12 ) or as a rolling average ( FIG. 17 ). U.S. patent application Ser. No. 12/170,220 (“the Trending Application”), entitled “Dialysis System Having Trending and Alert Generation,” filed Nov. 3, 2008, the pertinent portions of which are incorporated expressly herein by reference and relied upon, discloses different rolling average UF trends and trends using statistical process control (“SPC”) for alarming/alerting. Such trends can be used alternatively or additionally to the single day trend shown in  FIG. 12 . 
       FIGS. 13, 14, 15 and 16  illustrate four different treatment scenarios. The continuous line indicates the volume of fluid that system  10  delivers and removes from the patient over time. The dashed line indicates the actual volume of fluid residing in the patient (“IPV”) at any given point in time. The difference between the machine delivered/removed volume and the actual volume is the patient&#39;s UF. The dotted line indicates the actual UF removed from the patient over time. 
       FIG. 13  illustrates a 50% tidal therapy using 1.5% dextrose dialysate. The trended 1600 ml total UF for such treatment is recalled from memory of system  10  and used to simulate the patient&#39;s actual IPV. The 1600 ml UF is split amongst ten treatments, yielding 160 ml removed per cycle as shown in  FIG. 13 .  FIG. 14  illustrates a 50% tidal therapy using 1.5% dextrose dialysate. The trended 2400 ml total UF for this treatment is recalled from memory of system  10  and used to simulate the patient&#39;s actual IPV. The 2400 ml UF is also split amongst ten treatments, yielding 240 ml removed per cycle as shown in  FIG. 14 . 
       FIG. 15  again illustrates a 50% tidal therapy using 1.5% dextrose dialysate. The trended 1600 ml total UF for such treatment is recalled from memory of system  10  and used to simulate the patient&#39;s actual IPV. Here, however, the total UF removed is only 1280 ml, short by 320 ml. The 1280 ml UF is again split amongst ten treatments, yielding 128 ml removed per cycle as shown in  FIG. 15 . Because the predicted UF from the patient&#39;s actual trend sets a good starting place, and because the 50% tidal therapy is forgiving in terms of having enough planned residual volume to accept lower than expected residual volumes (here due to less UF than expected), the treatment is able to use all of the prescribed solution, maintain the prescribed dwell times and finish therapy on time. 
       FIG. 16  again illustrates a 50% tidal therapy using 1.5% dextrose dialysate. The trended 1600 ml total UF for such treatment is recalled from memory of system  10  and used to simulate the patient&#39;s actual IPV. Here, however, the total UF removed is more than expected, 1920 ml, greater by 320 ml. The 1920 ml UF is again split amongst ten treatments, yielding 192 ml removed per cycle as shown in  FIG. 16 . Again, the predicted UF from the patient&#39;s actual trend sets a good starting place. The 50% tidal therapy is forgiving in terms of setting the planned residual volume high enough so that the planned drain can take place each cycle, which at least does not add to the effect of the additional UF. The treatment is thus able to use all of the prescribed solution, maintain prescribed dwell times, and finish therapy on time. 
     In the therapies of  FIGS. 15 and 16 , all of the dialysis solution is used, the dwell times are as prescribed, the potential for low drain alarms is minimized and the maximum patient volume is limited to less than that with CCPD therapies. The trending of the UF (based upon osmotic concentration) accordingly allows tidal treatments to be used in a very advantageous manner. 
     In one embodiment, system  10  trends a running average of the patient&#39;s UF and displays same for both the patient and clinician. The displayed trended time interval can be varied from a week to a month to multiple months (see also Trending Application). The user in one embodiment can scroll forward or may scroll backward to see the results for the preceding ninety days. System  10  in one embodiment enables the user to select the prescription ID axis (e.g., via input device  22  ( FIG. 1 ) or a touch screen operable with video monitor  20 ), after which system  10  changes the display to that shown in  FIG. 12 , in which two or more different prescriptions or dextrose levels are trended independently. 
       FIG. 17  shows which dialysate is used on a given day (prescription  1  or prescription  2 ), the desired UF volume, and a trended rolling seven day average actual UF. System  10  can therefore use as its predicted UF the previous day&#39;s UF volume (if the same therapy and dialysate is used) or an averaged UF data point for the same dialysate/treatment. As discussed in the Trending Application, the UF trends, e.g.,  FIGS. 12 and 17 , may be maintained at the logic implementer of the cycler  12  or at a remote server, e.g., located at a dialysis clinic or doctor&#39;s office. In either case, networked communication can allow any one or more of the patient, clinician and doctor to view the UF trend. 
     As discussed, using trended UF values allows the programmed UF to be withdrawn during the tidal therapy to be predicted quite accurately. The actual patient volume (“IPV”) will likewise trend very close to the IPV that the APD cycler  12  expects to be in the patient&#39;s peritoneum as illustrated in  FIGS. 13 to 16 . System  10  in one embodiment is programmed such that if the UF trend changes by more than a preset percentage, the system alerts the user so that he/she can consult a PD doctor or clinician. System  10  in one embodiment automatically adjusts the UF that is programmed for the osmotic agent being used to use the most recent UF trended data point. 
     Alternatively, the machine alerts the patent to make a change to the programmed UF, so that the user knows of the change. To this end, each osmotic agent or dextrose level dialysate can be associated with a different dialysate ID or number, which the patient enters into the system. System  10  then calls up a screen for the particular dialysate, so that the patient can make the machine suggested change. The Trending Application referenced above describes situations in which the patient&#39;s doctor or clinician is notified when the patient&#39;s UF trends too far away from an expected level for a particular dialysate. 
     It is important to drain the patient fully at the start of any APD therapy. This holds true for the 50% tidal therapy with UF based upon trending of multiple concentration osmotic agents. In the initial and final drains, however, the patient can be sitting up and will typically drain better, compared with draining when lying down in a supine position. The patient can also move around a little since he/she will be awake and is not inconvenienced when doing so. 
     System  10  in one embodiment knows how much fluid resides in the patient&#39;s peritoneum at the start of a therapy. The system remembers the type and volume that it filled the day before for a last fill. System  10  in one embodiment trends initial drain volumes and posts an alert if drain flow stops before the normal initial drain volume has been recovered knowing the previous day&#39;s last fill volume and dextrose level. System  10  can also query the user regarding any day exchange that the patient made the previous day not using machine  12  as a possible explanation for an abnormal initial drain. 
       FIG. 18  shows an alternative embodiment in which system  10  and machine  12  continuously remove UF during dwell so that the patient&#39;s IPV does not increase over the dwell. Here again, it is important to know the UF accurately for the patient and a particular dextrose level, in order to know how much fluid to remove from the patient over the dwell. The UF volume divided by the dwell time informs system  10  and cycler  12  of the proper flow rate at which to remove the UF volume from the patient. 
     While 50% tidal percentage with trended UF provides one very suitable therapy (see predicted results for different patients below), the percentage can be varied if desired or if a different percentage is predicted for a particular patient to have better clearance. For patients that typically drain well, the percentage can be higher, e.g., 65% or 75% and still allow prevent the vast majority of low drain alarms, prevent short fills, and complete therapy on time with the prescribed amount of dwell. Percentages below 50% are also possible. 
     Predicted Therapy Outcomes 
     Simulations were performed on APD Therapies (Tables 10 and 11) using PD prediction software called Renalsoft™, provided by the assignee of the present disclosure. The Trending Application referenced above discusses the prediction software in detail. The simulations were performed to show two different comparisons (i) 50% tidal (using trended UF prediction) versus standard APD Therapy (complete drains, no shorting of fills) and (ii) 85% tidal to simulate CCPD with 15% shorted next fills versus standard APD Therapy (complete drains, no shorting of fills). The software compared the therapies for the three patient body sizes and the four different PET categories, yielding twelve different patient types shown in Table 10. 
     
       
         
           
               
             
               
                 TABLE 10 
               
             
            
               
                   
               
               
                 Definition of Patient Types 
               
            
           
           
               
               
            
               
                 Patient Type 
                 Description: BSA Size and PET Category 
               
               
                   
               
            
           
           
               
               
            
               
                 1 
                 BSA-Less Than-1.71-PET-HIGH 
               
               
                 2 
                 BSA-1.71-2.00-PET-HIGH 
               
               
                 3 
                 BSA-Greater Than-2.00-PET-HIGH 
               
               
                 4 
                 BSA-Less Than-1.71-PET-HIGH-AVE 
               
               
                 5 
                 BSA-1.71-2.00-PET-HIGH-AVE 
               
               
                 6 
                 BSA-Greater Than-2.00-PET-HIGH-AVE 
               
               
                 7 
                 BSA-Less Than-1.71-PET-LOW 
               
               
                 8 
                 BSA-Greater Than-2.00-PET-LOW 
               
               
                 9 
                 BSA-Less Than-1.71-PET-LOW-AVE 
               
               
                 10 
                 BSA-Less Than-1.71-PET-LOW-AVE 
               
               
                 11 
                 BSA-1.71-2.00-PET-LOW-AVE 
               
               
                 12 
                 BSA-Greater Than-2.00-PET-LOW-AVE 
               
               
                   
               
            
           
         
       
     
     As seen in Table 11, in all instances, the 50% tidal therapy resulted in higher creatinine clearances when compared to a standard CCPD therapy with full drains and no shorted fills. The results were consistent for both dry days and wet days. As shown, 50% tidal therapy based upon actual patient UF trending with both 1.5% and 2.5% dextrose dialysate offers superior clearances. And as discussed herein, 50% tidal therapy is shown to have fewer low drain volume alarms and better control of the volume of fluid in the patient when compared to conventional APD. 
     
       
         
           
               
             
               
                 TABLE 11 
               
             
            
               
                   
               
               
                 Creatinine Clearance Increase (PerCent) for 50% Tidal over APD 
               
            
           
           
               
               
            
               
                 No Last Fill = Dry Day 
                 Last Fill = Wet Day 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                   
                 50% Tidal 
                 Standard APD 
                   
                   
                 50% Tidal 
                 Standard APD 
                   
               
               
                   
                 Creatinine 
                 Creatinine 
                   
                   
                 Creatinine 
                 Creatinine 
                   
               
               
                   
                 Clearance 
                 Clearance 
                   
                   
                 Clearance 
                 Clearance 
                   
               
               
                 Patient 
                 L/wk/ 
                 L/wk/ 
                 Percent 
                 Patient 
                 L/wk/ 
                 L/wk/ 
                 Percent 
               
               
                 Type 
                 1.73 m 2   
                 1.73 m 2   
                 Increase 
                 Type 
                 1.73 m 2   
                 1.73 m 2   
                 Increase 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 1 
                 49.98 
                 48.36 
                  3.3% 
                 1 
                 70.01 
                 68.34 
                 2.4% 
               
               
                 2 
                 48.62 
                 47.08 
                  3.3% 
                 2 
                 67.01 
                 65.43 
                 2.4% 
               
               
                 3 
                 39.06 
                 37.45 
                  4.3% 
                 3 
                 53.90 
                 52.26 
                 3.1% 
               
               
                 4 
                 44.70 
                 41.87 
                  6.8% 
                 4 
                 64.04 
                 61.19 
                 4.7% 
               
               
                 5 
                 35.63 
                 32.03 
                 11.2% 
                 5 
                 53.51 
                 51.67 
                 3.6% 
               
               
                 6 
                 35.38 
                 33.32 
                  6.2% 
                 6 
                 50.63 
                 48.57 
                 4.2% 
               
               
                 7 
                 25.36 
                 22.45 
                 13.0% 
                 7 
                 43.41 
                 40.46 
                 7.3% 
               
               
                 8 
                 23.51 
                 20.99 
                 12.0% 
                 8 
                 39.30 
                 36.78 
                 6.9% 
               
               
                 9 
                 24.58 
                 22.31 
                 10.2% 
                 9 
                 37.47 
                 35.20 
                 6.4% 
               
               
                 10 
                 36.73 
                 33.57 
                  9.4% 
                 10 
                 55.74 
                 52.55 
                 6.1% 
               
               
                 11 
                 30.90 
                 28.10 
                 10.0% 
                 11 
                 48.53 
                 45.70 
                 6.2% 
               
               
                 12 
                 26.56 
                 24.10 
                 10.2% 
                 12 
                 41.56 
                 39.08 
                 6.3% 
               
               
                   
               
            
           
         
       
     
     An alternative to the 50% tidal therapy is to short a subsequent fill in a CCPD therapy that experiences an incomplete drain when attempting to bring the patient&#39;s IPV to zero. The subsequent fill can be shorted by the amount that the previous drain was short. In this manner, system  10  limits the amount that the patient can be overfilled to the amount of fluid that has been ultrafiltered from the patient. Assuming, for example, that each drain is 15% short except for the last drain, the resulting change in creatinine clearance is shown in Table 12. For most patients, the clearances are reduced primarily because there is unused fluid left in the supply/heater bags at the end of the therapy. In the example illustrated below, 1080 ml out of a total therapy volume of 12000 ml (Dry Day) or 14000 ml (Wet Day) is not used. 
     
       
         
           
               
             
               
                 TABLE 12 
               
             
            
               
                   
               
               
                 Creatinine Clearances for Smart APD (85% Tidal) Versus APD 
               
            
           
           
               
               
            
               
                 No Last Fill = Dry Day 
                 Last Fill = Wet Day 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                   
                 85% Tidal 
                 Standard APD 
                   
                   
                 85% Tidal 
                 Standard APD 
                   
               
               
                   
                 Creatinine 
                 Creatinine 
                   
                   
                 Creatinine 
                 Creatinine 
                   
               
               
                   
                 Clearance 
                 Clearance 
                   
                   
                 Clearance 
                 Clearance 
                   
               
               
                 Patient 
                 L/wk/ 
                 L/wk/ 
                 Percent 
                 Patient 
                 L/wk/ 
                 L/wk/ 
                 Percent 
               
               
                 Type 
                 1.73 m 2   
                 1.73 m 2   
                 Change 
                 Type 
                 1.73 m 2   
                 1.73 m 2   
                 Change 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 1 
                 46.12 
                 48.36 
                 −4.6% 
                 1 
                 66.11 
                 68.34 
                 −3.3% 
               
               
                 2 
                 44.92 
                 47.08 
                 −4.6% 
                 2 
                 63.27 
                 65.43 
                 −3.3% 
               
               
                 3 
                 35.82 
                 37.45 
                 −4.4% 
                 3 
                 50.63 
                 52.26 
                 −3.1% 
               
               
                 4 
                 40.78 
                 41.87 
                 −2.6% 
                 4 
                 60.08 
                 61.19 
                 −1.8% 
               
               
                 5 
                 32.77 
                 32.03 
                  2.3% 
                 5 
                 50.60 
                 51.67 
                 −2.1% 
               
               
                 6 
                 32.32 
                 33.32 
                 −3.0% 
                 6 
                 47.55 
                 48.57 
                 −2.1% 
               
               
                 7 
                 22.70 
                 22.45 
                  1.1% 
                 7 
                 40.71 
                 40.46 
                  0.6% 
               
               
                 8 
                 21.15 
                 20.99 
                  0.8% 
                 8 
                 36.90 
                 36.78 
                  0.3% 
               
               
                 9 
                 22.27 
                 22.31 
                 −0.2% 
                 9 
                 35.12 
                 35.20 
                 −0.2% 
               
               
                 10 
                 33.28 
                 33.57 
                 −0.9% 
                 10 
                 52.23 
                 52.55 
                 −0.6% 
               
               
                 11 
                 27.95 
                 28.10 
                 −0.5% 
                 11 
                 45.53 
                 45.70 
                 −0.4% 
               
               
                 12 
                 23.97 
                 24.10 
                 −0.5% 
                 12 
                 38.93 
                 39.08 
                 −0.4% 
               
               
                   
               
            
           
         
       
     
     The data in Table 12 predicts a reduced creatinine clearance when system  10  shorts succeeding fills by the amount that preceding drains fall short of recovering 100% of the previous fill volume. This is to be expected because some of the fresh dialysis solution was not used. Tables 10 and 11 show that a 50% tidal therapy is at least as effective as a properly performed APD CCPD therapy and does not run the risk of low drain alarms or fill shorts that the APD CCPD therapy runs. 
     Patient Recirculation 
     Single lumen patient lines have a recirculation volume (volume of fluid left in the patient line at the end of drain and returned at the start of the next fill) that reduces the therapeutic affect of the therapy. For example, if the internal volume of the patient line  38   d  ( FIG. 1 ) is 42 ml and the fill volume is 1000 ml, 42/1000*100%=4.2% of the available fluid is wasted. Patients with larger fill volumes can use longer patient lines  38   d  without losing a larger percentage of their dialysis fluid. Patients with smaller fill volumes sometimes have to use shorter patient lines  38   d  with smaller inside diameters to avoid wasting a higher percentage of their dialysis solution. 
     The 50% tidal therapy discussed herein will drain and fill moving a smaller solution volume when compared to a standard APD therapy. A patient with a 2000 ml fill volume on 50% tidal is accordingly wasting the same percentage of dialysis solution as a patient with a 1000 ml fill volume on full drain APD. 
     In one embodiment, system  10  addresses the recirculation issue by limiting the length of the standard patient line to about twenty-two feet instead of the thirty-three feet that currently can be used. 
     Alternately, patient line  38   d  is a dual lumen patient line, so that only the transfer set volume is recirculated. Dual lumen patient line  38   d  does not result in an increase in the size of the patient&#39;s transfer set. Using dual lumen patient line  38   d  allows the length of the line to be any desired, suitable length, and the same disposable set  30  ( FIG. 1 ) and cassette  50  ( FIG. 2 ) can be used for both the low fill mode and the standard fill mode. One suitable dual lumen patient line  38   d  and method therefore is disclosed in U.S. patent application Ser. No. 11/773,795, entitled, “Dialysis System Having Dual Patient Line Connection And Prime”, filed Jul. 5, 2007, the relevant portion of which is incorporated herein by reference and relied upon. 
     It should be understood that various changes and modifications to the presently preferred embodiments described herein will be apparent to those skilled in the art. Such changes and modifications can be made without departing from the spirit and scope of the present subject matter and without diminishing its intended advantages. It is therefore intended that such changes and modifications be covered by the appended claims.