Patent Publication Number: US-2023157589-A1

Title: Focused sterilization and sterilized sub-assemblies for analyte monitoring systems

Description:
CROSS REFERENCE TO RELATED APPLICATIONS 
     This application is a continuation of U.S. patent application Ser. No. 17/708,685, filed Mar. 30, 2022, which is a continuation of U.S. patent application Ser. No. 17/112,700, filed Dec. 4, 2020, now U.S. Pat. No. 11,331,010, which is a continuation of International Patent Application No. PCT/US2019/035810, filed Jun. 6, 2019, which claims the benefit of U.S. Provisional Patent Application No. 62/681,906 filed Jun. 7, 2018, U.S. Provisional Patent Application No. 62/681,914 filed Jun. 7, 2018, U.S. Provisional Patent Application No. 62/776,536 filed Dec. 7, 2018, U.S. Provisional Patent Application No. 62/784,074 filed Dec. 21, 2018, U.S. Provisional Patent Application No. 62/788,475 filed Jan. 4, 2019, U.S. Provisional Patent Application No. 62/798,703 filed Jan. 30, 2019, U.S. Provisional Patent Application No. 62/829,100 filed Apr. 4, 2019, U.S. Provisional Patent Application No. 62/836,203 filed Apr. 19, 2019, U.S. Provisional Patent Application No. 62/836,193 filed Apr. 19, 2019, U.S. Provisional Patent Application No. 62/847,572 filed May 14, 2019, and U.S. Provisional Patent Application No. 62/849,442 filed May 17, 2019 which are hereby incorporated by reference in their entireties. 
    
    
     BACKGROUND 
     Diabetes is an incurable chronic disease in which the body does not produce or properly utilize insulin, a hormone produced by the pancreas that regulates blood glucose. When blood glucose levels rise, e.g., after a meal, insulin lowers the blood glucose levels by moving the blood glucose from the blood and into the body cells. When the pancreas does not produce sufficient insulin (a condition known as Type I Diabetes) or the body does not properly utilize insulin (a condition known as Type II Diabetes), the blood glucose remains in the blood, which could result in hyperglycemia or abnormally high blood sugar levels. 
     If symptoms of diabetes are not carefully monitored and treated, numerous complications can arise, including diabetic ketoacidosis, nonketotic hyperosmolar coma, cardiovascular disease, stroke, kidney failure, foot ulcers, eye damage, and nerve damage. Traditionally, monitoring has involved an individual pricking a finger to draw blood and testing the blood for glucose levels. Advancements that are more recent have allowed for continuous and long-term monitoring of blood glucose using biological sensors that are maintained in contact with bodily fluids for periods of days, weeks, or longer. 
     Analyte monitoring systems, for example, have been developed to facilitate long-term monitoring of bodily fluid analytes, such as glucose. Analyte monitoring systems typically include a sensor applicator configured to place a biological sensor into contact with a bodily fluid. More specifically, during delivery of the sensor to the skin of a user, at least a portion of the sensor is positioned below the skin surface, e.g., in the subcutaneous or dermal tissue. 
     It is important for devices implanted in the body or positioned below the skin to be sterile upon insertion. Sterilization can include any number of processes that effectively eliminate or kill transmissible agents, such as bacteria, fungi, and viruses. These transmittable agents, if not eliminated from the device, may be substantially detrimental to the health and safety of the user. 
     Some but not all analyte monitoring systems might require separate sterilization processes to sterilize the sensor and the electronic components. Electron beam sterilization, for example, is one example of radiation sterilization that can be used to terminally sterilize the sensor. Radiation sterilization, however, can harm the electronic components associated with the sensor. Consequently, the electronic components are commonly sterilized via gaseous chemical sterilization using, for example, ethylene oxide. Ethylene oxide, however, can damage the chemistry provided on the sensor. As such, integrating electronics and the sensor into one unit can complicate the sterilization process. 
     These issues can be worked around by separating the components into a sensor unit (e.g., a biological analyte sensor) and an adaptor unit (containing the data transmission electronics), so that each component can be packaged and sterilized separately using the appropriate sterilization method. This approach, however, requires additional components, additional packaging, additional process steps, and final user assembly of the two components, introducing a possibility of user error. Thus, a need exists for analyte monitoring systems that may be sterilized without separating the components. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       The following figures are included to illustrate certain aspects of the present disclosure, and should not be viewed as exclusive embodiments. The subject matter disclosed is capable of considerable modifications, alterations, combinations, and equivalents in form and function, without departing from the scope of this disclosure. 
         FIG.  1    is a conceptual diagram depicting an example analyte monitoring system that may incorporate one or more embodiments of the present disclosure. 
         FIGS.  2 A- 2 G  are progressive views of the assembly and application of the system of  FIG.  1    incorporating a two-piece architecture. 
         FIGS.  3 A and  3 B  are isometric and side views, respectively, of an example sensor control device. 
         FIGS.  4 A and  4 B  are isometric and exploded views, respectively, of the plug assembly of  FIGS.  3 A- 3 B . 
         FIGS.  5 A and  5 B  are exploded and bottom isometric views, respectively, of the electronics housing of  FIGS.  3 A- 3 B . 
         FIGS.  6 A and  6 B  are side and cross-sectional side views, respectively, of the sensor applicator of  FIG.  1    with the cap of  FIG.  2 B  coupled thereto. 
         FIG.  7 A  is an enlarged cross-sectional side view of the sensor control device of  FIG.  6 B  mounted within the cap of  FIG.  6 B . 
         FIG.  7 B  is an enlarged cross-sectional side view of another embodiment of the sensor control device of  FIG.  6 B  mounted within the sensor applicator of  FIG.  6 B . 
         FIGS.  8 - 12    are schematic diagrams of example external sterilization assemblies, according to one or more embodiments of the present disclosure. 
         FIG.  13    is an isometric view of an example sensor control device. 
         FIG.  14 A  is a side view of the sensor applicator of  FIG.  1   . 
         FIG.  14 B  is a cross-sectional side view of the sensor applicator of  FIG.  14 A . 
         FIG.  15    is a cross-sectional side view of the sensor applicator of  FIG.  14 A  and another example embodiment of the external sterilization assembly of  FIG.  14 B , according to one or additional more embodiments. 
         FIG.  16    is a cross-sectional side view of the sensor applicator of  FIG.  14 A  and another example embodiment of the external sterilization assembly of  FIG.  14 B , according to one or more additional embodiments. 
         FIGS.  17 A and  17 B  are isometric top and bottom views, respectively, of one example of the external sterilization assembly of  FIG.  14 B , according to one or more embodiments. 
         FIG.  18    is an isometric view of an example sensor control device. 
         FIG.  19 A  is a side view of the sensor applicator of  FIG.  1   . 
         FIG.  19 B  is a partial cross-sectional side view of the sensor applicator of  FIG.  3 A . 
         FIGS.  20 A- 20 C  are various views of the applicator insert of  FIG.  19 B , according to one or more embodiments of the disclosure. 
         FIG.  21    is another cross-sectional side view of the sensor applicator of  FIG.  19 A  showing a hybrid sterilization assembly, according to one or more embodiments of the disclosure. 
         FIGS.  22 A and  22 B  are isometric and cross-sectional side views, respectively, of another embodiment of the applicator insert of  FIGS.  20 A- 20 C . 
         FIG.  23    is a diagram of an example analyte monitoring system that may incorporate one or more embodiments of the present disclosure. 
         FIG.  24    is a schematic diagram of an example internal sterilization assembly, according to one or more additional embodiments of the present disclosure. 
         FIG.  25    is a schematic diagram of another example internal sterilization assembly, according to one or more additional embodiments of the present disclosure. 
         FIGS.  26 A and  26 B  are isometric and side views, respectively, of an example sensor control device. 
         FIGS.  27 A and  27 B  are isometric and exploded views, respectively, of the plug assembly of  FIGS.  26 A- 26 B . 
         FIG.  27 C  is an exploded isometric bottom view of the plug and the preservation vial. 
         FIGS.  28 A and  28 B  are exploded and bottom isometric views, respectively, of the electronics housing of  FIGS.  26 A- 26 B . 
         FIGS.  29 A and  29 B  are side and cross-sectional side views, respectively, of the sensor applicator of  FIG.  1    with the cap of  FIG.  2 B  coupled thereto. 
         FIG.  30    is a perspective view of an example embodiment of the cap of  FIGS.  29 A- 29 B . 
         FIG.  31    is a cross-sectional side view of the sensor control device positioned within the cap. 
         FIGS.  32 A and  32 B  are isometric and side views, respectively, of an example sensor control device. 
         FIGS.  33 A and  33 B  are exploded perspective top and bottom views, respectively, of the sensor control device of  FIGS.  32 A- 32 B . 
         FIGS.  34 A and  34 B  are side and cross-sectional side views, respectively, of the sensor applicator of  FIG.  1    with the cap of  FIG.  2 B  coupled thereto. 
         FIG.  35    is an enlarged cross-sectional side view of the sensor control device mounted within the sensor applicator. 
         FIG.  36    is an enlarged cross-sectional bottom view of the sensor control device mounted atop the cap post. 
         FIGS.  37 A- 37 C  are isometric, side, and bottom views, respectively, of an example sensor control device. 
         FIGS.  38 A and  38 B  are isometric exploded top and bottom views, respectively, of the sensor control device of  FIGS.  37 A- 37 C . 
         FIGS.  39 A- 39 D  show example assembly of the sensor control device of  FIGS.  37 A- 37 C . 
         FIGS.  40 A and  40 B  are side and cross-sectional side views, respectively, of a sensor applicator with the pre-assembled sensor control device of  FIGS.  37 A- 37 C  arranged therein. 
         FIGS.  41 A and  41 B  are enlarged cross-sectional views of the sensor control device during example radiation sterilization. 
         FIG.  42    is a plot that graphically depicts approximate penetration depth as a function of e-beam energy level for a one-sided e-beam sterilization (or irradiation) process. 
         FIG.  43    is a cross-sectional side view of a sensor applicator with the pre-assembled sensor control device of  FIGS.  37 A- 37 C  arranged therein, according to one or more additional embodiments. 
         FIG.  44    is a side view of an example sensor control device. 
         FIG.  45    is an exploded view of the sensor control device of  FIG.  44   . 
         FIG.  46 A  is a cross-sectional side view of the assembled sealed subassembly of  FIG.  45   , according to one or more embodiments. 
         FIG.  46 B  is a cross-sectional side view of the fully assembled sensor control device of  FIG.  44   . 
         FIGS.  47 A and  47 B  are side and cross-sectional side views, respectively, of an example embodiment of the sensor applicator of  FIG.  1    with the cap of  FIG.  2 B  coupled thereto. 
         FIG.  48    is a perspective view of an example embodiment of the cap of  FIGS.  47 A- 47 B . 
         FIG.  49    is a cross-sectional side view of the sensor control device positioned within the cap of  FIGS.  47 A- 47 B . 
         FIGS.  50 A and  50 B  are isometric and side views, respectively, of another example sensor control device. 
         FIGS.  51 A and  51 B  are exploded isometric top and bottom views, respectively of the sensor control device of  FIGS.  50 A- 50 B . 
         FIG.  52    is a cross-sectional side view of an assembled sealed subassembly, according to one or more embodiments. 
         FIGS.  53 A- 53 C  are progressive cross-sectional side views showing assembly of the sensor applicator with the sensor control device of  FIGS.  50 A- 50 B . 
         FIGS.  54 A and  54 B  are perspective and top views, respectively, of the cap post of  FIG.  53 C , according to one or more additional embodiments. 
         FIG.  55    is a cross-sectional side view of the sensor control device of  FIGS.  50 A- 50 B  positioned within the cap of  FIGS.  12 B- 12 C . 
         FIGS.  56 A and  56 B  are cross-sectional side views of the sensor applicator ready to deploy the sensor control device to a target monitoring location. 
         FIGS.  57 A- 57 C  are progressive cross-sectional side views showing assembly and disassembly of an example embodiment of the sensor applicator with the sensor control device of  FIGS.  50 A- 50 B . 
         FIG.  58 A  is an isometric bottom view of the housing, according to one or more embodiments. 
         FIG.  58 B  is an isometric bottom view of the housing with the sheath and other components at least partially positioned therein. 
         FIG.  59    is an enlarged cross-sectional side view of the sensor applicator with the sensor control device installed therein, according to one or more embodiments. 
         FIG.  60 A  is an isometric top view of the cap, according to one or more embodiments. 
         FIG.  60 B  is an enlarged cross-sectional view of the engagement between the cap and the housing, according to one or more embodiments. 
         FIGS.  61 A and  61 B  are isometric views of the sensor cap and the collar, respectively, according to one or more embodiments. 
         FIG.  62    is an isometric top view of an example sensor control device, according to one or more embodiments of the present disclosure. 
         FIG.  63    is a schematic side view of an example sensor applicator, according to one or more embodiments of the present disclosure. 
         FIGS.  64 A and  64 B  are exploded isometric views of the sensor applicator and the sensor control device of  FIGS.  62  and  63   . 
         FIGS.  65 A- 65 D  are progressive cross-sectional side views of the sensor applicator of  FIGS.  63  and  64 A- 64 B  depicting example deployment of a sensor control device, according to one or more embodiments. 
         FIG.  66    is an enlarged cross-sectional side view of an engagement between the sensor retainer and the sensor control device of  FIGS.  65 A- 65 D , according to one or more embodiments. 
         FIG.  67    is an exploded isometric view of another sensor applicator with the sensor control device of  FIG.  62   , according to one or more additional embodiments. 
         FIGS.  68 A- 68 D  are progressive cross-sectional side views of the sensor applicator of  FIG.  67    depicting example deployment of the sensor control device, according to one or more embodiments. 
         FIG.  69 A  is an enlarged schematic view of the sharp hub and the fingers of the sensor retainer. 
         FIGS.  69 B and  69 C  are enlarged schematic views of the fingers interacting with the upper portion of the needle shroud. 
         FIGS.  70 A and  70 B  are enlarged cross-sectional side views of example engagement between the sensor retainer and the sensor control device, according to one or more embodiments. 
         FIGS.  71 A and  71 B  are isometric and cross-sectional side views, respectively, of an example sensor retainer, according to one or more embodiments of the present disclosure. 
         FIGS.  72 A and  72 B  are enlarged cross-sectional side views of the sensor retainer of  FIGS.  71 A- 71 B  retaining the sensor control device, according to one or more embodiments. 
         FIGS.  73 A and  73 B  are side and cross-sectional side views, respectively, of an example sensor applicator, according to one or more embodiments. 
         FIGS.  74 A and  74 B  are isometric top and bottom views, respectively, of the internal applicator cover of  FIG.  73 B . 
         FIG.  75    is an isometric view of an example embodiment of the sensor cap of  FIG.  73 B , according to one or more embodiments. 
         FIG.  76    is an isometric, cross-sectional side view of the sensor cap of  FIG.  75    received by the internal applicator cover of  FIGS.  74 A- 74 B , according to one or more embodiments. 
         FIG.  77    shows progressive removal of the applicator cap of  FIG.  73 A  and the internal applicator cover of  FIGS.  74 A- 74 B  from the sensor applicator of  FIGS.  73 A- 73 B , according to one or more embodiments. 
         FIG.  78    is a schematic diagram of an example sensor applicator, according to one or more additional embodiments of the present disclosure. 
         FIG.  79    is an exploded view of an example sensor control device, according to one or more additional embodiments. 
         FIG.  80    is a bottom view of one embodiment of the sensor control device of  FIG.  79   . 
         FIGS.  81 A and  81 B  are isometric and side views, respectively, of a sensor control device in accordance with one or more embodiments of the present disclosure. 
         FIG.  82    is an exploded perspective top view of the sensor control device of  FIG.  81 A . 
         FIG.  83    is a cross-sectional side view in perspective of an example sensor control device assembly including a sensor control device of  FIG.  81 A  mounted within the sensor applicator, the sensor control device being compatible with the analyte monitoring system of  FIG.  1   . 
         FIG.  84    is an enlarged cross-sectional side view of the sensor control device assembly of  FIG.  83   . 
         FIG.  85    is a bottom view of a few members of the sensor control device assembly of  FIG.  83   , the members including the sensor control device held in a sensor carrier of the sensor applicator. 
         FIG.  86    is a schematic diagram of an example sterilization assembly, according to one or more embodiments of the present disclosure. 
         FIG.  87    is a schematic diagram of another example sterilization assembly, according to one or more embodiments of the present disclosure. 
         FIG.  88 A  is a schematic bottom view of another example sterilization assembly, according to one or more embodiments of the present disclosure. 
         FIGS.  88 B and  88 C  are schematic bottom views of alternative embodiments of the sterilization assembly of  FIG.  88 A , according to one or more additional embodiments of the present disclosure. 
         FIG.  89    is an isometric schematic view of an example sensor control device, according to one or more embodiments. 
         FIG.  90    is a schematic diagram of another example sterilization assembly, according to one or more embodiments. 
         FIGS.  91 A and  91 B  are side and isometric views, respectively, of an example sensor control device, according to one or more embodiments of the present disclosure. 
         FIGS.  92 A and  92 B  are exploded, isometric top and bottom views, respectively, of the sensor control device of  FIG.  2   , according to one or more embodiments. 
         FIG.  93    is a cross-sectional side view of the sensor control device of  FIGS.  91 A- 91 B and  92 A- 92 B , according to one or more embodiments. 
         FIG.  93 A  is an exploded isometric view of a portion of another embodiment of the sensor control device of  FIGS.  91 A- 91 B and  92 A- 92 B . 
         FIG.  94 A  is an isometric bottom view of the mount of  FIGS.  91 A- 91 B and  92 A- 92 B . 
         FIG.  94 B  is an isometric top view of the sensor cap of  FIGS.  91 A- 91 B and  92 A- 92 B . 
         FIGS.  95 A and  95 B  are side and cross-sectional side views, respectively, of an example sensor applicator, according to one or more embodiments. 
         FIGS.  96 A and  96 B  are perspective and top views, respectively, of the cap post of  FIG.  95 B , according to one or more embodiments. 
         FIG.  97    is a cross-sectional side view of the sensor control device positioned within the applicator cap, according to one or more embodiments. 
         FIG.  98    is a cross-sectional view of a sensor control device showing example interaction between the sensor and the sharp. 
         FIG.  99    is a cross-sectional side view of an example analyte monitoring system enclosure used to house at least a portion of a sensor control device. 
         FIG.  100 A  is an enlarged cross-sectional side view of the interface between the sensor applicator and the cap as indicated by the dashed box of  FIG.  99   . 
         FIG.  100 B  is an enlarged cross-sectional side view of the interface between the sensor applicator and the cap as indicated by the dashed box of  FIG.  99    during or after gaseous chemical sterilization. 
         FIG.  101    is a cross-sectional side view of another example analyte monitoring system enclosure used to house at least a portion of the sensor control device of  FIG.  1   . 
         FIGS.  102 A- 102 C  provide finite element analysis results corresponding to the interface between the housing and the cap during example gaseous chemical sterilization. 
         FIG.  103    is an isometric view of an example sensor control device. 
         FIGS.  104 A and  104 B  are exploded, isometric views of the sensor control device of  FIG.  103   , according to one or more embodiments. 
         FIG.  105    is a cross-sectional side view of the assembled sensor control device of  FIGS.  104 A- 104 B , according to one or more embodiments. 
         FIG.  106    is an isometric view of another example sensor control device. 
         FIGS.  107 A and  107 B  are exploded, isometric views of the sensor control device of  FIG.  106   , according to one or more embodiments. 
         FIG.  108    is a cross-sectional side view of the assembled sensor control device of  FIGS.  107 A- 107 B , according to one or more embodiments. 
         FIG.  109    is an isometric view of an example converting process for manufacturing a sensor control device in accordance with the principles of the present disclosure. 
         FIGS.  110 A- 110 E  depict progressive fabrication of the sensor control device of  FIG.  109   , according to one or more embodiments. 
         FIG.  111 A  is a top view of the sensor control device of  FIG.  109    in preparation for pressure testing and/or vacuum sealing, according to one or more embodiments. 
         FIG.  111 B  is a cross-sectional side view of the sensor control device of  FIG.  109    with a compressor. 
         FIG.  112    is a partial cross-sectional side view of an example sensor control device, according to one or more embodiments. 
         FIG.  113    is a cross-sectional side view of an example sensor applicator, according to one or more embodiments. 
         FIGS.  114 A and  114 B  are top and bottom perspective views, respectively, of an example embodiment of the plug of  FIGS.  27 A- 27 B . 
         FIGS.  115 A and  115 B  are perspective views depicting an example embodiment of the connector of  FIGS.  27 A- 27 B  in open and closed states, respectively. 
         FIG.  116    is a perspective view of an example embodiment of the sensor of  FIGS.  27 A- 27 B . 
         FIGS.  117 A and  117 B  are bottom and top perspective views, respectively, depicting an example embodiment of a sensor module assembly. 
         FIGS.  118 A and  118 B  are close-up partial views of an example embodiment of the sensor plug of  FIGS.  114 A- 114 B  having certain axial stiffening features. 
         FIG.  119    is a side view of an example sensor, according to one or more embodiments of the disclosure. 
         FIGS.  120 A and  120 B  are isometric and partially exploded isometric views of an example connector assembly, according to one or more embodiments. 
         FIG.  120 C  is an isometric bottom view of the connector of  FIGS.  120 A- 120 B . 
         FIGS.  121 A and  121 B  are isometric and partially exploded isometric views of another example connector assembly, according to one or more embodiments. 
         FIG.  121 C  is an isometric bottom view of the connector of  FIGS.  121 A- 121 B . 
     
    
    
     DETAILED DESCRIPTION 
     The present application is generally related to systems, devices, and methods for assembling an applicator and sensor control device for use in an in vivo analyte monitoring system. 
       FIG.  1    is a conceptual diagram depicting an example analyte monitoring system  100  that may incorporate one or more embodiments of the present disclosure. A variety of analytes can be detected and quantified using the system  100  (hereafter “the system  100 ”) including, but not limited to, acetyl choline, amylase, bilirubin, cholesterol, chorionic gonadotropin, creatine kinase (e.g., CK-MB), creatine, DNA, fructosamine, glucose, glutamine, growth hormones, hormones, ketones (e.g., ketone bodies), lactate, oxygen, peroxide, prostate-specific antigen, prothrombin, RNA, thyroid stimulating hormone, and troponin. The concentration of drugs, such as, but not limited to, antibiotics (e.g., gentamicin, vancomycin, and the like), digitoxin, digoxin, drugs of abuse, theophylline, and warfarin, may also be determined. 
     As illustrated, the system  100  includes a sensor applicator  102  (alternately referred to as an “inserter”), a sensor control device  104  (also referred to as an “in vivo analyte sensor control device”), and a reader device  106 . The sensor applicator  102  is used to deliver the sensor control device  104  to a target monitoring location on a user&#39;s skin (e.g., the arm of the user). Once delivered, the sensor control device  104  is maintained in position on the skin with an adhesive patch  108  coupled to the bottom of the sensor control device  104 . A portion of a sensor  110  extends from the sensor control device  104  and is positioned such that it can be transcutaneously positioned and otherwise retained under the surface of the user&#39;s skin during the monitoring period. 
     An introducer may be included to promote introduction of the sensor  110  into tissue. The introducer may comprise, for example, a needle often referred to as a “sharp.” Alternatively, the introducer may comprise other types of devices, such as a sheath or a blade. The introducer may transiently reside in proximity to the sensor  110  prior to tissue insertion and then be withdrawn afterward. While present, the introducer may facilitate insertion of the sensor  110  into tissue by opening an access pathway for the sensor  110  to follow. For example, the introducer may penetrate the epidermis to provide an access pathway to the dermis to allow subcutaneous implantation of the sensor  110 . After opening the access pathway, the introducer may be withdrawn (retracted) so that it does not represent a hazard while the sensor  110  remains in place. In illustrative embodiments, the introducer may be solid or hollow, beveled or non-beveled, and/or circular or non-circular in cross-section. In more particular embodiments, suitable introducers may be comparable in cross-sectional diameter and/or tip design to an acupuncture needle, which may have a cross-sectional diameter of about 250 microns. It is to be recognized, however, that suitable introducers may have a larger or smaller cross-sectional diameter if needed for particular applications. 
     In some embodiments, a tip of the introducer (while present) may be angled over the terminus of the sensor  110 , such that the introducer penetrates a tissue first and opens an access pathway for the sensor  110 . In other illustrative embodiments, the sensor  110  may reside within a lumen or groove of the introducer, with the introducer similarly opening an access pathway for the sensor  110 . In either case, the introducer is subsequently withdrawn after facilitating sensor  110  insertion. Moreover, the introducer (sharp) can be made of a variety of materials, such as various types of metals and plastics. 
     When the sensor control device  104  is properly assembled, the sensor  110  is placed in communication (e.g., electrical, mechanical, etc.) with one or more electrical components or sensor electronics included within the sensor control device  104 . In some applications, for example, the sensor control device  104  may include a printed circuit board (PCB) having a data processor (e.g., an application specific integrated circuit or ASIC) mounted thereto, and the sensor  110  may be operatively coupled to the data processor which, in turn, may be coupled with an antenna and a power source. 
     The sensor control device  104  and the reader device  106  are configured to communicate with one another over a local communication path or link  112 , which may be wired or wireless, uni- or bi-directional, and encrypted or non-encrypted. The reader device  106  may constitute an output medium for viewing analyte concentrations and alerts or notifications determined by the sensor  110  or a processor associated therewith, as well as allowing for one or more user inputs, according to some embodiments. The reader device  106  may be a multi-purpose smartphone or a dedicated electronic reader instrument. While only one reader device  106  is shown, multiple reader devices  106  may be present in certain instances. 
     The reader device  106  may also be in communication with a remote terminal  114  and/or a trusted computer system  116  via communication path(s)/link(s)  118  and/or  120 , respectively, which also may be wired or wireless, uni- or bi-directional, and encrypted or non-encrypted. The reader device  106  may also or alternately be in communication with a network  122  (e.g., a mobile telephone network, the internet, or a cloud server) via communication path/link  124 . The network  122  may be further communicatively coupled to remote terminal  114  via communication path/link  126  and/or the trusted computer system  116  via communication path/link  128 . 
     Alternately, the sensor control device  104  may communicate directly with the remote terminal  114  and/or the trusted computer system  116  without an intervening reader device  106  being present. For example, the sensor  110  may communicate with the remote terminal  114  and/or the trusted computer system  116  through a direct communication link to the network  122 , according to some embodiments, as described in U.S. Pat. No. 10,136,816, incorporated herein by reference in its entirety. 
     Any suitable electronic communication protocol may be used for each of the communication paths or links, such as near field communication (NFC), radio frequency identification (RFID), BLUETOOTH® or BLUETOOTH® low energy protocols, WiFi, or the like. The remote terminal  114  and/or the trusted computer system  116  may be accessible, according to some embodiments, by individuals other than a primary user who have an interest in the user&#39;s analyte levels. The reader device  106  may include a display  130  and an optional input component  132 . The display  130  may comprise a touch-screen interface, according to some embodiments. 
     In some embodiments, the sensor control device  104  may automatically forward data to the reader device  106 . For example, analyte concentration data may be communicated automatically and periodically, such as at a certain frequency as data is obtained or after a certain time period has passed, with the data being stored in a memory until transmittal (e.g., every minute, five minutes, or other predetermined time period). In other embodiments, the sensor control device  104  may communicate with the reader device  106  in a non-automatic manner and not according to a set schedule. For example, data may be communicated from the sensor control device  104  using RFID technology when the sensor electronics are brought into communication range of the reader device  106 . Until communicated to the reader device  106 , data may remain stored in a memory of the sensor control device  104 . Thus, a patient does not have to maintain close proximity to the reader device  106  at all times, and can instead upload data when convenient. In yet other embodiments, a combination of automatic and non-automatic data transfer may be implemented. For example, data transfer may continue on an automatic basis until the reader device  106  is no longer in communication range of the sensor control device  104 . 
     The sensor control device  104  is often included with the sensor applicator  104  in what is known as a “two-piece” architecture that requires final assembly by a user before the sensor  110  can be properly delivered to the target monitoring location. More specifically, the sensor  110  and the associated electrical components included in the sensor control device  104  are provided to the user in multiple (two) packages, and the user must open the packaging and follow instructions to manually assemble the components before delivering the sensor  110  to the target monitoring location with the sensor applicator  102 . 
     More recently, however, advanced designs of sensor control devices and sensor applicators have resulted in a one-piece architecture that allows the system to be shipped to the user in a single, sealed package that does not require any final user assembly steps. Rather, the user need only open one package and subsequently deliver the sensor control device to the target monitoring location. The one-piece system architecture may prove advantageous in eliminating component parts, various fabrication process steps, and user assembly steps. As a result, packaging and waste are reduced, and the potential for user error or contamination to the system is mitigated. 
     In the illustrated embodiment, the system  100  may comprise what is known as a “two-piece” architecture that requires final assembly by a user before the sensor  110  can be properly delivered to the target monitoring location. More specifically, the sensor  110  and the associated electrical components included in the sensor control device  104  are provided to the user in multiple (two) packages, where each may or may not be sealed with a sterile barrier but are at least enclosed in packaging. The user must open the packaging and follow instructions to manually assemble the components and subsequently deliver the sensor  110  to the target monitoring location with the sensor applicator  102 . 
       FIGS.  2 A- 2 G  are progressive views of the assembly and application of the system  100  incorporating a two-piece architecture.  FIGS.  2 A and  2 B  depict the first and second packages, respectively, provided to the user for final assembly. More specifically,  FIG.  2 A  depicts a sensor container or tray  202  that has a removable lid  204 . The user prepares the sensor tray  202  by removing the lid  204 , which acts as a sterile barrier to protect the internal contents of the sensor tray  202  and otherwise maintain a sterile internal environment. Removing the lid  204  exposes a platform  206  positioned within the sensor tray  202 , and a plug assembly  207  (partially visible) is arranged within and otherwise strategically embedded within the platform  206 . The plug assembly  207  includes a sensor module (not shown) and a sharp module (not shown). The sensor module carries the sensor  110  ( FIG.  1   ), and the sharp module carries an associated sharp used to help deliver the sensor  110  transcutaneously under the user&#39;s skin during application of the sensor control device  104  ( FIG.  1   ). 
       FIG.  2 B  depicts the sensor applicator  102  and the user preparing the sensor applicator  102  for final assembly. The sensor applicator  102  includes a housing  208  sealed at one end with an applicator cap  210 . In some embodiments, for example, an O-ring or another type of sealing gasket may seal an interface between the housing  208  and the applicator cap  210 . In at least one embodiment, the O-ring or sealing gasket may be molded onto one of the housing  208  and the applicator cap  210 . The applicator cap  210  provides a barrier that protects the internal contents of the sensor applicator  102 . In particular, the sensor applicator  102  contains an electronics housing (not shown) that retains the electrical components for the sensor control device  104  ( FIG.  1   ), and the applicator cap  210  may or may not maintain a sterile environment for the electrical components. Preparation of the sensor applicator  102  includes uncoupling the housing  208  from the applicator cap  210 , which can be accomplished by unscrewing the applicator cap  210  from the housing  208 . The applicator cap  210  can then be discarded or otherwise placed aside. 
       FIG.  2 C  depicts the user inserting the sensor applicator  102  into the sensor tray  202 . The sensor applicator  102  includes a sheath  212  configured to be received by the platform  206  to temporarily unlock the sheath  212  relative to the housing  208 , and also temporarily unlock the platform  206  relative to the sensor tray  202 . Advancing the housing  208  into the sensor tray  202  results in the plug assembly  207  ( FIG.  2 A ) arranged within the sensor tray  202 , including the sensor and sharp modules, being coupled to the electronics housing arranged within the sensor applicator  102 . 
     In  FIG.  2 D , the user removes the sensor applicator  102  from the sensor tray  202  by proximally retracting the housing  208  with respect to the sensor tray  202 . 
       FIG.  2 E  depicts the bottom or interior of the sensor applicator  102  following removal from the sensor tray  202  ( FIG.  2   ). The sensor applicator  102  is removed from the sensor tray  202  with the sensor control device  104  fully assembled therein and positioned for delivery to the target monitoring location. As illustrated, a sharp  220  extends from the bottom of the sensor control device  104  and carries a portion of the sensor  110  within a hollow or recessed portion thereof. The sharp  220  is configured to penetrate the skin of a user and thereby place the sensor  110  into contact with bodily fluid. 
       FIGS.  2 F and  2 G  depict example delivery of the sensor control device  104  to a target monitoring location  222 , such as the back of an arm of the user.  FIG.  2 F  shows the user advancing the sensor applicator  102  toward the target monitoring location  222 . Upon engaging the skin at the target monitoring location  222 , the sheath  212  collapses into the housing  208 , which allows the sensor control device  104  ( FIGS.  2 E and  2 G ) to advance into engagement with the skin. With the help of the sharp  220  ( FIG.  2 E ), the sensor  110  ( FIG.  2 E ) is advanced transcutaneously into the patient&#39;s skin at the target monitoring location  222 . 
       FIG.  2 G  shows the user retracting the sensor applicator  102  from the target monitoring location, with the sensor control device  104  successfully attached to the user&#39;s skin. The adhesive patch  108  ( FIG.  1   ) applied to the bottom of sensor control device  104  adheres to the skin to secure the sensor control device  104  in place. The sharp  220  ( FIG.  2 E ) is automatically retracted when the housing  208  is fully advanced at the target monitoring location  222 , while the sensor  110  ( FIG.  2 E ) is left in position to measure analyte levels. 
     For the two-piece architecture system, the sensor tray  202  ( FIG.  2 A ) and the sensor applicator  102  ( FIG.  2 B ) are provided to the user as separate packages, thus requiring the user to open each package and finally assemble the system. In some applications, the discrete, sealed packages allow the sensor tray  202  and the sensor applicator  102  to be sterilized in separate sterilization processes unique to the contents of each package and otherwise incompatible with the contents of the other. 
     More specifically, the sensor tray  202 , which includes the plug assembly  207  ( FIG.  2 A ), including the sensor  110  ( FIGS.  1  and  2 E ) and the sharp  220  ( FIG.  2 E ), may be sterilized using radiation sterilization, such as electron beam (or “e-beam”) irradiation. Radiation sterilization, however, can damage the electrical components arranged within the electronics housing of the sensor control device  104 . Consequently, if the sensor applicator  102 , which contains the electronics housing of the sensor control device  104 , needs to be sterilized, it may be sterilized via another method, such as gaseous chemical sterilization using, for example, ethylene oxide. Gaseous chemical sterilization, however, can damage the enzymes or other chemistry and biologics included on the sensor  110 . Because of this sterilization incompatibility, the sensor tray  202  and the sensor applicator  102  may be sterilized in separate sterilization processes and subsequently packaged separately, and thereby requiring the user to finally assemble the components upon receipt. 
     According to embodiments of the present disclosure, the system  100  ( FIG.  1   ) may comprise a one-piece architecture that incorporates sterilization techniques specifically designed for a one-piece architecture. The one-piece architecture allows the system  100  to be shipped to the user in a single, sealed package that does not require any final user assembly steps. Rather, the user need only open one package and subsequently deliver the sensor control device to the target monitoring location, as generally described above with reference to  FIGS.  2 E- 2 G . The one-piece system architecture described herein may prove advantageous in eliminating component parts, various fabrication process steps, and user assembly steps. As a result, packaging and waste are reduced, and the potential for user error or contamination to the system is mitigated. 
     Focused Electron Beam Sterilization with Collimator 
       FIGS.  3 A and  3 B  are isometric and side views, respectively, of an example sensor control device  302 , according to one or more embodiments of the present disclosure. The sensor control device  302  (alternately referred to as a “puck”) may be similar in some respects to the sensor control device  104  of  FIG.  1    and therefore may be best understood with reference thereto. The sensor control device  302  may replace the sensor control device  104  of  FIG.  1    and, therefore, may be used in conjunction with the sensor applicator  102  ( FIG.  1   ), which delivers the sensor control device  302  to a target monitoring location on a user&#39;s skin. 
     The sensor control device  302 , however, may be incorporated into a one-piece system architecture. Unlike the two-piece architecture system, for example, a user is not required to open multiple packages and finally assemble the sensor control device  302 . Rather, upon receipt by the user, the sensor control device  302  is already fully assembled and properly positioned within the sensor applicator  102 . To use the sensor control device  302 , the user need only break one barrier (e.g., the applicator cap  210  of  FIG.  2 B ) before promptly delivering the sensor control device  302  to the target monitoring location. 
     As illustrated, the sensor control device  302  includes an electronics housing  304  that is generally disc-shaped and may have a circular cross-section. In other embodiments, however, the electronics housing  304  may exhibit other cross-sectional shapes, such as ovoid (e.g., pill-shaped), a squircle, or polygonal, without departing from the scope of the disclosure. The electronics housing  304  may be configured to house or otherwise contain various electrical components used to operate the sensor control device  302 . 
     The electronics housing  304  may include a shell  306  and a mount  308  that is matable with the shell  306 . The shell  306  may be secured to the mount  308  via a variety of ways, such as a snap fit engagement, an interference fit, sonic welding, or one or more mechanical fasteners (e.g., screws). In some cases, the shell  306  may be secured to the mount  308  such that a sealed interface therebetween is generated. In such embodiments, a gasket or other type of seal material may be positioned at or near the outer diameter (periphery) of the shell  306  and the mount  308 , and securing the two components together may compress the gasket and thereby generate a sealed interface. In other embodiments, an adhesive may be applied to the outer diameter (periphery) of one or both of the shell  306  and the mount  308 . The adhesive secures the shell  306  to the mount  308  and provides structural integrity, but may also seal the interface between the two components and thereby isolate the interior of the electronics housing  304  from outside contamination. If the sensor control device  302  is assembled in a controlled environment, there may be no need to terminally sterilize the internal electrical components. Rather, the adhesive coupling may provide a sufficient sterile barrier for the assembled electronics housing  304 . 
     The sensor control device  302  may further include a plug assembly  310  that may be coupled to the electronics housing  304 . The plug assembly  310  may be similar in some respects to the plug assembly  207  of  FIG.  2 A . For example, the plug assembly  310  may include a sensor module  312  (partially visible) interconnectable with a sharp module  314  (partially visible). The sensor module  312  may be configured to carry and otherwise include a sensor  316  (partially visible), and the sharp module  314  may be configured to carry and otherwise include a sharp  318  (partially visible) used to help deliver the sensor  316  transcutaneously under a user&#39;s skin during application of the sensor control device  302 . As illustrated, corresponding portions of the sensor  316  and the sharp  318  extend from the electronics housing  304  and, more particularly, from the bottom of the mount  308 . The exposed portion of the sensor  316  may be received within a hollow or recessed portion of the sharp  318 . The remaining portion of the sensor  316  is positioned within the interior of the electronics housing  304 . 
       FIGS.  4 A and  4 B  are isometric and exploded views, respectively, of the plug assembly  310 , according to one or more embodiments. The sensor module  312  may include the sensor  316 , a plug  402 , and a connector  404 . The plug  402  may be designed to receive and support both the sensor  316  and the connector  404 . As illustrated, a channel  406  may be defined through the plug  402  to receive a portion of the sensor  316 . Moreover, the plug  402  may provide one or more deflectable arms  407  configured to snap into corresponding features provided on the bottom of the electronics housing  304  ( FIGS.  3 A- 3 B ). 
     The sensor  316  includes a tail  408 , a flag  410 , and a neck  412  that interconnects the tail  408  and the flag  410 . The tail  408  may be configured to extend at least partially through the channel  406  and extend distally from the plug  402 . The tail  408  includes an enzyme or other chemistry or biologic and, in some embodiments, a membrane may cover the chemistry. In use, the tail  408  is transcutaneously received beneath a user&#39;s skin, and the chemistry included thereon helps facilitate analyte monitoring in the presence of bodily fluids. 
     The flag  410  may comprise a generally planar surface having one or more sensor contacts  414  (three shown in  FIG.  4 B ) arranged thereon. The sensor contact(s)  414  may be configured to align with a corresponding number of compliant carbon impregnated polymer modules (not shown) encapsulated within the connector  404 . 
     The connector  404  includes one or more hinges  418  that enables the connector  404  to move between open and closed states. The connector  404  is depicted in  FIGS.  4 A- 4 B  in the closed state, but can pivot to the open state to receive the flag  410  and the compliant carbon impregnated polymer module(s) therein. The compliant carbon impregnated polymer module(s) provide electrical contacts  420  (three shown) configured to provide conductive communication between the sensor  316  and corresponding circuitry contacts provided within the electronics housing  304  ( FIGS.  3 A- 3 B ). The connector  404  can be made of silicone rubber and may serve as a moisture barrier for the sensor  316  when assembled in a compressed state and after application to a user&#39;s skin. 
     The sharp module  314  includes the sharp  318  and a sharp hub  422  that carries the sharp  318 . The sharp  318  includes an elongate shaft  424  and a sharp tip  426  at the distal end of the shaft  424 . The shaft  424  may be configured to extend through the channel  406  and extend distally from the plug  402 . Moreover, the shaft  424  may include a hollow or recessed portion  428  that at least partially circumscribes the tail  408  of the sensor  316 . The sharp tip  426  may be configured to penetrate the skin while carrying the tail  408  to put the active chemistry present on the tail  408  into contact with bodily fluids. 
     The sharp hub  422  may include a hub small cylinder  430  and a hub snap pawl  432 , each of which may be configured to help couple the plug assembly  310  (and the entire sensor control device  302 ) to the sensor applicator  102  ( FIG.  1   ). 
       FIGS.  5 A and  5 B  are exploded and bottom isometric views, respectively, of the electronics housing  304 , according to one or more embodiments. The shell  306  and the mount  308  operate as opposing clamshell halves that enclose or otherwise substantially encapsulate the various electronic components of the sensor control device  302  ( FIGS.  3 A- 3 B ). 
     A printed circuit board (PCB)  502  may be positioned within the electronics housing  304 . A plurality of electronic modules (not shown) may be mounted to the PCB  502  including, but not limited to, a data processing unit, resistors, transistors, capacitors, inductors, diodes, and switches. The data processing unit may comprise, for example, an application specific integrated circuit (ASIC) configured to implement one or more functions or routines associated with operation of the sensor control device  302 . More specifically, the data processing unit may be configured to perform data processing functions, where such functions may include but are not limited to, filtering and encoding of data signals, each of which corresponds to a sampled analyte level of the user. The data processing unit may also include or otherwise communicate with an antenna for communicating with the reader device  106  ( FIG.  1   ). 
     As illustrated, the shell  306 , the mount  308 , and the PCB  502  each define corresponding central apertures  504 ,  506 , and  508 , respectively. When the electronics housing  304  is assembled, the central apertures  504 ,  506 , and  508  coaxially align to receive the plug assembly  310  ( FIGS.  4 A- 4 B ) therethrough. A battery  510  may also be housed within the electronics housing  304  and configured to power the sensor control device  302 . 
     In  FIG.  5 B , a plug receptacle  512  may be defined in the bottom of the mount  308  and provide a location where the plug assembly  310  ( FIGS.  4 A- 4 B ) may be received and coupled to the electronics housing  304 , and thereby fully assemble the sensor control device  302  ( FIG.  3 A- 3 B ). The profile of the plug  402  ( FIGS.  4 A- 4 B ) may match or be shaped in complementary fashion to the plug receptacle  512 , and the plug receptacle  512  may provide one or more snap ledges  514  (two shown) configured to interface with and receive the deflectable arms  407  ( FIGS.  4 A- 4 B ) of the plug  402 . The plug assembly  310  is coupled to the electronics housing  304  by advancing the plug  402  into the plug receptacle  512  and allowing the deflectable arms  407  to lock into the corresponding snap ledges  514 . When the plug assembly  310  ( FIGS.  4 A- 4 B ) is properly coupled to the electronics housing  304 , one or more circuitry contacts  516  (three shown) defined on the underside of the PCB  502  may make conductive communication with the electrical contacts  420  ( FIGS.  4 A- 4 B ) of the connector  404  ( FIGS.  4 A- 4 B ). 
       FIGS.  6 A and  6 B  are side and cross-sectional side views, respectively, of the sensor applicator  102  with the applicator cap  210  coupled thereto. More specifically,  FIGS.  6 A- 6 B  depict how the sensor applicator  102  might be shipped to and received by a user, according to at least one embodiment. In some embodiments, however, the sensor applicator  102  might further be sealed within a bag (not shown) and delivered to the user within the bag. The bag may be made of a variety of materials that help prevent the ingress of humidity into the sensor applicator  102 , which might adversely affect the sensor  316 . In at least one embodiment, for example, the sealed back might be made of foil. Any and all of the sensor applicators described or discussed herein may be sealed within and delivered to the user within the bag. 
     According to the present disclosure, and as seen in  FIG.  6 B , the sensor control device  302  is already assembled and installed within the sensor applicator  102  prior to being delivered to the user. The applicator cap  210  may be threaded to the housing  208  and include a tamper ring  602 . Upon rotating (e.g., unscrewing) the applicator cap  210  relative to the housing  208 , the tamper ring  602  may shear and thereby free the applicator cap  210  from the sensor applicator  102 . Following which, the user may deliver the sensor control device  302  to the target monitoring location, as generally described above with reference to  FIGS.  2 E- 2 G . 
     In some embodiments, as mentioned above, the applicator cap  210  may be secured to the housing  208  via a sealed engagement to protect the internal components of the sensor applicator  102 . In at least one embodiment, for example, an O-ring or another type of sealing gasket may seal an interface between the housing  208  and the applicator cap  210 . The O-ring or sealing gasket may be a separate component part or alternatively molded onto one of the housing  208  and the applicator cap  210 . 
     The housing  208  may be made of a variety of rigid materials. In some embodiments, for example, the housing  208  may be made of a thermoplastic polymer, such as polyketone. In other embodiments, the housing  208  may be made of cyclic olefin copolymer (COC), which can help prevent moisture ingress into the interior of the sensor applicator  102 . As will be appreciated, any and all of the housings described or discussed herein may be made of polyketone or COC. 
     With specific reference to  FIG.  6 B , the sensor control device  302  may be loaded into the sensor applicator  102  by mating the sharp hub  422  with a sensor carrier  604  included within the sensor applicator  102 . Once the sensor control device  302  is mated with the sensor carrier  604 , the applicator cap  210  may then be secured to the sensor applicator  102 . 
     In the illustrated embodiment, a collimator  606  is positioned within the applicator cap  210  and may generally help support the sensor control device  302  while contained within the sensor applicator  102 . In some embodiments, the collimator  606  may form an integral part or extension of the applicator cap  210 , such as being molded with or overmolded onto the applicator cap  210 . In other embodiments, the collimator  606  may comprise a separate structure fitted within or attached to the applicator cap  210 , without departing from the scope of the disclosure. In yet other embodiments, as discussed below, the collimator  606  may be omitted in the package received by the user, but otherwise used while sterilizing and preparing the sensor applicator  102  for delivery. 
     The collimator  606  may be designed to receive and help protect parts of the sensor control device  302  that need to be sterile, and isolate the sterile components of the sensor applicator  102  from microbial contamination from other locations within the sensor control device  302 . To accomplish this, the collimator  606  may define or otherwise provide a sterilization zone  608  (alternately referred to as a “sterile barrier enclosure” or a “sterile sensor path”) configured to receive the sensor  316  and the sharp  318  as extending from the bottom of the electronics housing  304 . The sterilization zone  608  may generally comprise a hole or passageway extending at least partially through the body of the collimator  606 . In the illustrated embodiment, the sterilization zone  608  extends through the entire body of the collimator  606 , but may alternatively extend only partially therethrough, without departing from the scope of the disclosure. 
     When the sensor control device  302  is loaded into the sensor applicator  102  and the applicator cap  210  with the collimator  606  is secured thereto, the sensor  316  and the sharp  318  may be positioned within a sealed region  610  at least partially defined by the sterilization zone  608 . The sealed region  610  is configured to isolate the sensor  316  and the sharp  318  from external contamination and may include (encompass) select portions of the interior of the electronics housing  304  and the sterilization zone  608  of the collimator  606 . 
     While positioned within the sensor applicator  102 , the fully assembled sensor control device  302  may be subjected to radiation sterilization  612 . The radiation sterilization  612  may comprise, for example, e-beam irradiation, but other methods of sterilization may alternatively be used including, but not limited to, low energy X-ray irradiation. In some embodiments, the radiation sterilization  612  may be delivered either through continuous processing irradiation or through pulsed beam irradiation. In pulsed beam irradiation, the beam of radiation sterilization  612  is focused at a target location and the component part or device to be sterilized is moved to the target location at which point the radiation sterilization  612  is activated to provide a directed pulse of radiation. The radiation sterilization  612  is then turned off, and another component part or device to be sterilized is moved to the target location and the process is repeated. 
     The collimator  606  may be configured to focus the radiation (e.g., beams, waves, energy, etc.) from the radiation sterilization  612  toward the components that are required to be sterile, such as the sensor  316  and the sharp  318 . More specifically, the hole or passageway of the sterilization zone  608  allows transmission of the radiation to impinge upon and sterilize the sensor  316  and the sharp  318 , while the remaining portions of the collimator  606  prevent (impede) the propagating radiation from disrupting or damaging the electronic components within the electronics housing  304 . 
     The sterilization zone  608  can exhibit any suitable cross-sectional shape necessary to properly focus the radiation on the sensor  316  and the sharp  318  for sterilization. In the illustrated embodiment, for example, the sterilization zone  608  is circular cylindrical, but could alternatively exhibit a polygonal cross-sectional shape, such as cubic or rectangular (e.g., including parallelogram), without departing from the scope of the disclosure. 
     In the illustrated embodiment, the sterilization zone  608  provides a first aperture  614   a  at a first end and a second aperture  614   b  at a second end opposite the first end. The first aperture  614   a  may be configured to receive the sensor  316  and the sharp  318  into the sterilization zone  608 , and the second aperture  614   b  may allow the radiation (e.g., beams, waves, etc.) from the radiation sterilization  612  to enter the sterilization zone  608  and impinge upon the sensor  316  and the sharp  318 . In the illustrated embodiment, the first and second apertures  614   a,b  exhibit identical diameters. 
     The body of the collimator  606  reduces or eliminates the radiation sterilization  612  from penetrating through the body material and thereby damaging the electronic components within the electronics housing  304 . To accomplish this, in some embodiments, the collimator  606  may be made of a material that has a mass density greater than 0.9 grams per cubic centimeter (g/cc). One example material for the collimator  606  is polyethylene, but could alternatively comprise any material having a mass density similar to or greater than polyethylene. In some embodiments, for example, the material for the collimator  606  may comprise, but is not limited to, a metal (e.g., lead, stainless steel) or a high-density polymer. 
     In at least one embodiment, the design of the collimator  606  may be altered so that the collimator  606  may be made of a material that has a mass density less than 0.9 grams per cubic centimeter (g/cc) but still operate to reduce or eliminate the radiation sterilization  612  from impinging upon the electronic components within the electronics housing  304 . To accomplish this, in some embodiments, the size (e.g., length) of the collimator  606  may be increased such that the propagating electrons from the radiation sterilization  612  are required to pass through a larger amount of material before potentially impinging upon sensitive electronics. The larger amount of material may help absorb or dissipate the dose strength of the radiation sterilization  612  such that it becomes harmless to the sensitive electronics. In other embodiments, however, the converse may equally be true. More specifically, the size (e.g., length) of the collimator  606  may be decreased as long as the material for the collimator  606  exhibits a large enough mass density. 
     In addition to the radiation blocking characteristics of the body of the collimator  606 , in some embodiments, one or more shields  616  (one shown) may be positioned within the sensor housing  304  to protect sensitive electronic components from radiation while the sensor control device  302  is subjected to the radiation sterilization  612 . The shield  616 , for example, may be positioned to interpose a data processing unit  618  and the radiation source (e.g., an e-beam electron accelerator). In such embodiments, the shield  616  may be positioned adjacent to and otherwise aligned with the data processing unit  618  and the radiation source to block or mitigate radiation exposure (e.g., e-beam radiation or energy) that might otherwise damage the sensitive electronic circuitry of the data processing unit  618 . 
     The shield  616  may be made of any material capable of blocking (or substantially blocking) the transmission of radiation. Suitable materials for the shield  616  include, but are not limited to, lead, tungsten, iron-based metals (e.g., stainless steel), copper, tantalum, tungsten, osmium, or any combination thereof. Suitable metals may be corrosion-resistant, austenitic, and any non-magnetic metal with a density ranging between about 5 grams per cubic centimeter (g/cc) and about 15 g/cc. The shield  616  may be fabricated via a variety of manufacturing techniques including, but not limited to, stamping, casting, injection molding, sintering, two-shot molding, or any combination thereof. 
     In other embodiments, however, the shield  616  may comprise a metal-filled thermoplastic polymer such as, but not limited to, polyamide, polycarbonate, or polystyrene. In such embodiments, the shield  616  may be fabricated by mixing the shielding material in an adhesive matrix and dispensing the combination onto shaped components or otherwise directly onto the data processing unit  618 . Moreover, in such embodiments, the shield  616  may comprise an enclosure that encapsulates (or substantially encapsulates) the data processing unit  618 . 
     In some embodiments, a collimator seal  620  may be applied to the end of the collimator  606  to seal off the sterilization zone  608  and, thus, the sealed region  610 . As illustrated, the collimator seal  620  may seal the second aperture  614   b . The collimator seal  620  may be applied before or after the radiation sterilization  612 . In embodiments where the collimator seal  620  is applied before undertaking the radiation sterilization  612 , the collimator seal  620  may be made of a radiation permeable microbial barrier material that allows radiation to propagate therethrough. With the collimator seal  620  in place, the sealed region  610  is able to maintain a sterile environment for the assembled sensor control device  302  until the user removes (unthreads) the applicator cap  210 . 
     In some embodiments, the collimator seal  620  may comprise two or more layers of different materials. The first layer may be made of a synthetic material (e.g., a flash-spun high-density polyethylene fiber), such as Tyvek® available from DuPont®. Tyvek® is highly durable and puncture resistant and allows the permeation of vapors. The Tyvek® layer can be applied before or after the radiation sterilization  612 , and following the radiation sterilization  612 , a foil or other vapor and moisture resistant material layer may be sealed (e.g., heat sealed) over the Tyvek® layer to prevent the ingress of contaminants and moisture into the sterilization zone  608  and the sealed region  610 . In other embodiments, the collimator seal  620  may comprise only a single protective layer applied to the end of the collimator  606 . In such embodiments, the single layer is gas permeable for the sterilization process, but is also capable of protection against moisture and other harmful elements once the sterilization process is complete. Accordingly, the collimator seal  620  may operate as a moisture and contaminant layer, without departing from the scope of the disclosure. 
     It is noted that, while the sensor  316  and the sharp  318  extend from the bottom of the electronics housing  304  and into the sterilization zone  608  generally concentric with a centerline of the sensor applicator  102  and the applicator cap  210 , it is contemplated herein to have an eccentric arrangement. More specifically, in at least one embodiment, the sensor  316  and the sharp  318  may extend from the bottom of the electronics housing  304  eccentric to the centerline of the sensor applicator  102  and the applicator cap  210 . In such embodiments, the collimator  606  may be re-designed and otherwise configured such that the sterilization zone  608  is also eccentrically positioned to receive the sensor  316  and the sharp  318 , without departing from the scope of the disclosure. 
     In some embodiments, the collimator  606  may comprise a first or “internal” collimator capable of being housed within the applicator cap  210  or otherwise within the sensor applicator  102 , as generally described above. A second or “external” collimator (not shown) may also be included or otherwise used in the assembly (manufacturing) process to help sterilize the sensor applicator  102 . In such embodiments, the external collimator may be positioned external to the sensor applicator  102  and the applicator cap  210  and used simultaneously with the internal collimator  606  to help focus the radiation sterilization  612  on the sensor  316  and the sharp  318 . 
     In one embodiment, for example, the external collimator may initially receive the radiation sterilization  612 . Similar to the internal collimator  606 , the external collimator may provide or define a hole or passageway extending through the external collimator. The beams of the radiation sterilization  612  passing through the passageway of the external collimator may be focused and received into the sterilization zone  608  of the internal collimator  606  via the second aperture  614   b . Accordingly, the external collimator may operate to pre-focus the radiation energy, and the internal collimator  606  may fully focus the radiation energy on the sensor  316  and the sharp  318 . 
     In some embodiments, the internal collimator  606  may be omitted if the external collimator is capable of properly and fully focusing the radiation sterilization  612  to properly sterilize the sensor  316  and the sharp  318 . In such embodiments, the sensor applicator may be positioned adjacent the external collimator and subsequently subjected to the radiation sterilization  612 , and the external collimator may prevent radiation energy from damaging the sensitive electronics within the electronics housing  304 . Moreover, in such embodiments, the sensor applicator  102  may be delivered to the user without the internal collimator  606  positioned within the applicator cap  210 , thus eliminating complexity in manufacturing and use. 
       FIG.  7 A  is an enlarged cross-sectional side view of the sensor control device  302  mounted within the applicator cap  210 , according to one or more embodiments. As indicated above, portions of the sensor  316  and the sharp  318  may be arranged within the sealed region  610  and thereby isolated from external contamination. The sealed region  610  may include (encompass) select portions of the interior of the electronics housing  304  and the sterilization zone  608  of the collimator  606 . In one or more embodiments, the sealed region  610  may be defined and otherwise formed by at least a first seal  702   a , a second seal  702   b , and the collimator seal  620 . 
     The first seal  702   a  may be arranged to seal the interface between the sharp hub  422  and the top of the electronics housing  304 . More particularly, the first seal  702   a  may seal the interface between the sharp hub  422  and the shell  306 . Moreover, the first seal  702   a  may circumscribe the first central aperture  504  defined in the shell  306  such that contaminants are prevented from migrating into the interior of the electronics housing  304  via the first central aperture  504 . In some embodiments, the first seal  702   a  may form part of the sharp hub  422 . For example, the first seal  702   a  may be overmolded onto the sharp hub  422 . In other embodiments, the first seal  702   a  may be overmolded onto the top surface of the shell  306 . In yet other embodiments, the first seal  702   a  may comprise a separate structure, such as an O-ring or the like, that interposes the sharp hub  422  and the top surface of the shell  306 , without departing from the scope of the disclosure. 
     The second seal  702   b  may be arranged to seal the interface between the collimator  606  and the bottom of electronics housing  304 . More particularly, the second seal  702   b  may be arranged to seal the interface between the mount  308  and the collimator  606  or, alternatively, between the collimator  606  and the bottom of the plug  402  as received within the bottom of the mount  308 . In applications including the plug  402 , as illustrated, the second seal  702   b  may be configured to seal about and otherwise circumscribe the plug receptacle  512 . In embodiments that omit the plug  402 , the second seal  702   b  may alternatively circumscribe the second central aperture  506  ( FIG.  5 A ) defined in the mount  308 . Consequently, the second seal  702   b  may prevent contaminants from migrating into the sterilization zone  608  of the collimator  606  and also from migrating into the interior of the electronics housing  304  via the plug receptacle  512  (or alternatively the second central aperture  506 ). 
     In some embodiments, the second seal  702   b  may form part of the collimator  606 . For example, the second seal  702   b  may be overmolded onto the top of the collimator  606 . In other embodiments, the second seal  702   b  may be overmolded onto the plug  402  or the bottom of the mount  308 . In yet other embodiments, the second seal  702   b  may comprise a separate structure, such as an O-ring or the like, that interposes the collimator  606  and the plug  402  or the bottom of the mount  308 , without departing from the scope of the disclosure. 
     Upon loading the sensor control device  302  into the sensor applicator  102  ( FIG.  6 B ) and securing the applicator cap  210  to the sensor applicator  102 , the first and second seals  702   a,b  become compressed and generate corresponding sealed interfaces. The first and second seals  702   a,b  may be made of a variety of materials capable of generating a sealed interface between opposing structures. Suitable materials include, but are not limited to, silicone, a thermoplastic elastomer (TPE), polytetrafluoroethylene (PTFE or Teflon®), or any combination thereof. 
     As discussed above, the collimator seal  620  may be configured to seal off the bottom of the sterilization zone  608  and, thus, the bottom of the sealed region  610 . Accordingly, the first and second seals  702   a,b  and the collimator seal  620  each create corresponding barriers at their respective sealing locations. The combination of these seals  702   a,b  and  620  allows the sealed region  610  containing the sensor  316  and the sharp  318  to be terminally sterilized. 
       FIG.  7 B  is an enlarged cross-sectional side view of another embodiment of the sensor control device  302  mounted within the sensor applicator  102 , according to one or more embodiments. More specifically,  FIG.  7 B  depicts alternative embodiments of the first and second seals  702   a,b . The first seal  702   a  is again arranged to seal the interface between the sharp hub  422  and the top of the electronics housing  304  and, more particularly, seal off the first central aperture  504  defined in the shell  306 . In the illustrated embodiment, however, the first seal  702   a  may be configured to seal both axially and radially. More particularly, when the sensor control device  302  is introduced into the sensor applicator  102 , the sharp hub  422  is received by the sensor carrier  604 . The first seal  702   a  may be configured to simultaneously bias against one or more axially extending members  704  of the sensor carrier  604  and one or more radially extending members  706  of the sensor carrier  604 . Such dual biased engagement compresses the first seal  702   a  both axially and radially and thereby allows the first seal  702   a  to seal against the top of the electronics housing  304  in both the radial and axial directions. 
     The second seal  702   b  is again arranged to seal the interface between the collimator  606  and the bottom of electronics housing  304  and, more particularly, between the mount  308  and the collimator  606  or, alternatively, between the collimator  606  and the bottom of the plug  402  as received within the bottom of the mount  308 . In the illustrated embodiment, however, the second seal  702   b  may extend into the sterilization zone  608  and define or otherwise provide a cylindrical well  708  sized to receive the sensor  316  and the sharp  1408  as extending from the bottom of the mount  308 . In some embodiments, a desiccant  710  may be positioned within the cylindrical well to aid maintenance of a low humidity environment for biological components sensitive to moisture. 
     In some embodiments, the second seal  702   b  may be omitted and the collimator  606  may be directly coupled to the electronics housing  304 . More specifically, in at least one embodiment, the collimator  606  may be threadably coupled to the underside of the mount  308 . In such embodiments, the collimator  606  may provide or otherwise define a threaded extension configured to mate with a threaded aperture defined in the bottom of the mount  308 . Threadably coupling the collimator  606  to the mount  308  may seal the interface between the collimator  606  and the bottom of electronics housing  304 , and thus operate to isolate sealed region  610 . Moreover, in such embodiments, the pitch and gauge of the threads defined on the collimator  606  and the mount  308  may match those of the threaded engagement between the applicator cap  210  and the sensor applicator  102 . As a result, as the applicator cap  210  is threaded to or unthreaded from the sensor applicator  102 , the collimator  606  may correspondingly be threaded to or unthreaded from the electronics housing  404 . 
     Embodiments disclosed herein include: 
     A. An analyte monitoring system that includes a sensor applicator, a sensor control device positioned within the sensor applicator and including an electronics housing, a sensor extending from a bottom of the electronics housing, a sharp hub positioned adjacent a top of the electronics housing, and a sharp carried by the sharp hub and extending through the electronics housing and from the bottom of the electronics housing. The analyte monitoring system further including a cap coupled to the sensor applicator, and a collimator positioned within the cap and defining a sterilization zone that receives the sensor and the sharp extending from the bottom of the electronics housing. 
     B. A method of preparing an analyte monitoring system includes loading a sensor control device into a sensor applicator, the sensor control device including an electronics housing, a sensor extending from a bottom of the electronics housing, a sharp hub positioned adjacent a top of the electronics housing, and a sharp carried by the sharp hub and extending through the electronics housing and from the bottom of the electronics housing. The method further including securing a cap to the sensor applicator, wherein a collimator is arranged within the cap and defines a sterilization zone that receives the sensor and the sharp extending from the bottom of the electronics housing, sterilizing the sensor and the sharp with radiation sterilization while positioned within the sterilization zone, and preventing radiation from the radiation sterilization from damaging electronic components within the electronics housing with the collimator. 
     C. A method of preparing an analyte monitoring system includes loading a sensor control device into a sensor applicator, the sensor control device including an electronics housing, a sensor extending from a bottom of the electronics housing, a sharp hub positioned adjacent a top of the electronics housing, and a sharp carried by the sharp hub and extending through the electronics housing and from the bottom of the electronics housing. The method further including positioning the sensor applicator adjacent a collimator, subjecting the sensor and the sharp to radiation sterilization, and preventing radiation from the radiation sterilization from damaging the electronic components within the electronics housing with the collimator. 
     Each of embodiments A, B, and C may have one or more of the following additional elements in any combination: Element 1: wherein the sterilization zone comprises a passageway extending at least partially through the collimator. Element 2: wherein the sterilization zone comprises a cross-sectional shape selected from the group consisting of cubic, rectangular, and any combination thereof. Element 3: wherein the sterilization zone defines a first aperture at a first end and a second aperture at a second end, and wherein the first aperture receives the sensor and the sharp extending from the bottom of the electronics housing and a seal is arranged at the second aperture. Element 4: further comprising a sealed region encompassing the sterilization zone and a portion of an interior of the electronics housing, wherein the sealed region is defined by a first seal that seals an interface between the sharp hub and the top of the electronics housing, a second seal that seals an interface between the collimator and the bottom of the electronics housing, and a third seal that seals an end of the sterilization zone. Element 5: wherein the first seal circumscribes a central aperture defined in the top of the electronics housing and prevents contaminants from migrating into the portion of the interior of the electronics housing via the central aperture, and wherein the second seal circumscribes an aperture defined in the bottom of the electronics housing and prevents contaminants from migrating into the portion of the interior of the electronics housing via the aperture. Element 6: wherein the first seal provides one or both of an axial and a radial seal. Element 7: wherein the second seal extends into the sterilization zone and defines a cylindrical well that receives the sensor and the sharp. Element 8: further comprising a printed circuit board arranged within the electronics housing, a data processing unit mounted to the printed circuit board, and a shield positioned within the electronics housing to protect the data processing unit from radiation from a radiation sterilization process. Element 9: wherein the shield is made of a non-magnetic metal selected from the group consisting of lead, tungsten, iron, stainless steel, copper, tantalum, osmium, a thermoplastic polymer mixed with a non-magnetic metal, and any combination thereof. 
     Element 10: further comprising creating a sealed region as the cap is secured to the sensor applicator, the sealed region encompassing the sterilization zone and a portion of an interior of the electronics housing. Element 11: wherein creating the sealed region comprises sealing an interface between the sharp hub and the top of the electronics housing with a first seal, sealing an interface between the collimator and the bottom of the electronics housing with a second seal, and sealing an end of the sterilization zone with a third seal. Element 12: wherein sealing the interface between the sharp hub and the top of the electronics housing with the first seal comprises providing one or both of an axial seal and a radial seal with the first seal. Element 13: wherein the collimator comprises an internal collimator and sterilizing the sensor and the sharp with the radiation sterilization further comprises positioning the sensor applicator adjacent an external collimator arranged external to the sensor applicator, focusing the radiation with the external collimator to be received by the internal collimator, and preventing the radiation from damaging the electronic components within the electronics housing with the external and internal collimators. Element 14: wherein the sterilization zone defines a first aperture at a first end of the collimator and a second aperture at a second end of the collimator, and wherein sterilizing the sensor and the sharp comprises introducing radiation into the sterilization zone via the second aperture. Element 15: wherein preventing the radiation from the radiation sterilization from damaging the electronic components comprises blocking the radiation with the material of the collimator. Element 16: wherein a printed circuit board is arranged within the electronics housing and a data processing unit is mounted to the printed circuit board, the method further comprising protecting the data processing unit from radiation from the radiation sterilization process with a shield positioned within the electronics housing. 
     Element 17: wherein positioning the sensor applicator adjacent the collimator comprises arranging the collimator such that it resides external to the sensor applicator during the radiation sterilization. 
     By way of non-limiting example, exemplary combinations applicable to A, B, and C include: Element 2 with Element 3; Element 4 with Element 5; Element 4 with Element 6; Element 4 with Element 7; Element 8 with Element 9; Element 10 with Element 11; and Element 11 with Element 12. 
     External Sterilization Assemblies 
     Referring again briefly to  FIG.  1   , prior to being delivered to an end user, the sensor control device  104  must be sterilized to render the product free from viable microorganisms. The sensor  110  is commonly sterilized using radiation sterilization, such as electron beam (“e-beam”) irradiation. Radiation sterilization, however, can damage the electronic components within the sensor control device  104 , which are commonly sterilized via gaseous chemical sterilization (e.g., using ethylene oxide). Gaseous chemical sterilization, however, can damage the enzymes or other chemistry and biologics included on the sensor  110 . 
     In the past, this sterilization incompatibility has been circumvented by separating the sensor  110  and the electronic components and sterilizing each individually. This approach, however, requires additional parts, packaging, process steps, and final assembly by the user, which introduces a possibility of user error. According to the present disclosure, the sensor control device  104 , or any device requiring terminal sterilization, may be properly sterilized using an external sterilization assembly designed to focus sterilizing radiation (e.g., beams, waves, energy, etc.) toward component parts requiring sterilization, while simultaneously preventing the propagating radiation from disrupting or damaging sensitive electronic components. 
       FIG.  8    is a schematic diagram of an example external sterilization assembly  800 , according to one or more embodiments of the present disclosure. The external sterilization assembly  800  (hereafter the “assembly  800 ”) may be designed and otherwise configured to help sterilize a medical device  802 . The medical device  802  may comprise, for example, a sensor control device similar in some respects to the sensor control device  104  of  FIG.  1   , but could alternatively comprise other types of medical devices, health care products, or systems requiring terminal sterilization of specific component parts. Example medical devices or health care products that may incorporate the principles of the present disclosure include, but are not limited to, ingestible products, cardiac rhythm management (CRM) devices, under-skin sensing devices, externally mounted medical devices, or any combination thereof. 
     The medical device  802  may include a housing  804 , a part  806  requiring sterilization, and one or more radiation sensitive components  808 . In the illustrated embodiment, the radiation sensitive component  808  may be mounted to a printed circuit board (PCB)  810  positioned within the housing  804 , and the housing  804  may comprise an electronics housing for a sensor control device. The radiation sensitive component  808  may include one or more electronic modules such as, but not limited to, a data processing unit (e.g., an application specific integrated circuit or ASIC), a resistor, a transistor, a capacitor, an inductor, a diode, and a switch. In other embodiments, however, the radiation sensitive component  808  may comprise a radiation sensitive chemical solution or analyte, as described herein with reference to  FIG.  12   . 
     In some embodiments, the part  806  may comprise a sensor (e.g., the sensor  110  of  FIG.  1   ) that extends from the housing  804 . As illustrated, the part  806  may extend at an angle from the bottom of the housing  804 , but could alternatively extend perpendicular to the bottom or from another surface of the housing  804 . In at least one embodiment, the part  806  may further include a sharp that may also require sterilization and may help implant the sensor beneath the skin of a user. In some embodiments, as illustrated, the part  806  may be encapsulated with a cap  812  that provides a sealed barrier that protects exposed portions of the part  806  (e.g., the sensor and associated sharp) until the part  806  is needed for use. 
     The medical device  802  may be subjected to radiation sterilization  814  to properly sterilize the part  806  for use. Suitable radiation sterilization  814  processes include, but are not limited to, electron beam (e-beam) irradiation, gamma ray irradiation, X-ray irradiation, or any combination thereof. In embodiments that include the cap  812 , the cap  812  may be made of a material that permits propagation of the radiation  814  therethrough to facilitate radiation sterilization of the part  806 . Suitable materials for the cap  812  include, but are not limited to, a non-magnetic metal (e.g., aluminum, copper, gold, silver, etc.), a thermoplastic, ceramic, rubber (e.g., ebonite), a composite material (e.g., fiberglass, carbon fiber reinforced polymer, etc.), an epoxy, or any combination thereof. In some embodiments, the cap  812  may be transparent or translucent, but can otherwise be opaque, without departing from the scope of the disclosure. 
     The assembly  800  may include a radiation shield  816  positioned external to the medical device  802  and configured to help sterilize the part  806  while preventing (impeding) propagating radiation  814  from disrupting or damaging the radiation sensitive component(s)  808 . To accomplish this, the radiation shield  816  may provide a collimator  818  that generally comprises a hole or passageway extending at least partially through the body of the radiation shield  816 . The collimator  818  defines a sterilization zone  820  configured to focus the radiation  814  toward the part  806 . In the illustrated embodiment, the part  806  may also be received within the sterilization zone  820  for sterilization. 
     While focusing the radiation  814  (e.g., beams, waves, energy, etc.) toward the part  806 , the radiation shield  816  may be made of a material that reduces or eliminates the radiation  814  from penetrating therethrough and thereby damaging the radiation sensitive component(s)  808  within the housing  804 . In other words, the radiation shield  816  may be made of a material having a density sufficient to absorb the dose of the beam energy being delivered. In some embodiments, for example, the radiation shield  816  may be made of any material that has a mass density greater than 0.9 grams per cubic centimeter (g/cc). In other embodiments, however, the mass density of a suitable material may be less than 0.9 g/cc, without departing from the scope of the disclosure. Suitable materials for the radiation shield  816  include, but are not limited to, a high-density polymer, (e.g., polyethylene, polypropylene, polystyrene, polytetrafluoroethylene, etc.), a metal (e.g., lead, stainless steel, aluminum, etc.), any combination thereof, or any material having a mass density greater than 0.9 g/cc. 
     The collimator  818  can exhibit any suitable cross-sectional shape necessary to focus the radiation on the part  806  for sterilization. In the illustrated embodiment, for example, the collimator  818  is conical or frustoconical in shape. In other embodiments, however, the collimator  818  may exhibit a polygonal cross-sectional shape, such as cubic, rectangular (e.g., including parallelogram), or pyramidal, without departing from the scope of the disclosure. In yet other embodiments, the collimator  818  may exhibit a circular cross-sectional shape with parallel sides. 
     In the illustrated embodiment, the collimator  818  provides a first aperture  822   a  and a second aperture  822   b  where the first and second apertures  822   a,b  are defined at opposing ends of the sterilization zone  820 . The first aperture  822   a  may allow the radiation  814  to enter the sterilization zone  820  and impinge upon the part  806 , and the second aperture  822   b  may be configured to receive the part  806  into the sterilization zone  820 . In embodiments where the collimator  818  is conical or frustoconcial in shape, the second aperture  822   b  may have a diameter that is smaller than the diameter of the first aperture  822   a . In such embodiments, for example, the size of the second aperture  822   b  may range between about 0.5 mm and about 3.0 mm, and the size of the first aperture  822   a  may range between about 5.0 mm and about 16.0 mm. As will be appreciated, however, the respective diameters of the first and second apertures  822   a,b  may be greater or less than the ranges provided herein, without departing from the scope of the disclosure. Indeed, the diameters of the first and second apertures  822   a,b  may be scaled to the device size and need only be large enough to allow a sufficient dose of radiation to impinge upon the part  806 . Moreover, in at least one embodiment, the collimator  818  may be cylindrical in shape where the first and second apertures  822   a,b  exhibit identical diameters. 
     In some embodiments, the assembly  800  may further include a barrier shield  824  positioned within the housing  804 . The barrier shield  824  may be configured to help block radiation  814  (e.g., electrons) from propagating within the housing  804  toward the radiation sensitive component(s)  808 . The barrier shield  824  may be made of any of the materials mentioned above for the radiation shield  816 . In the illustrated embodiment, the barrier shield  824  is positioned vertically within the housing  804 , but may alternatively be positioned at any other angular configuration suitable for protecting the radiation sensitive component(s)  808 . 
       FIG.  9    is a schematic diagram of another example external sterilization assembly  900 , according to one or more additional embodiments of the present disclosure. The external sterilization assembly  900  (hereafter the “assembly  900 ”) may be similar in some respects to the assembly  800  of  FIG.  8    and therefore may be best understood with reference thereto, where like numerals will refer to similar components not described again. Similar to the assembly  800 , the assembly  900  may be designed and otherwise configured to help sterilize a medical device  902 . In the illustrated embodiment, the medical device  902  may comprise a two-piece sensor control device, but could alternatively comprise any of the medical devices mentioned herein with respect to the medical device  802 . 
     As illustrated, the medical device  902  includes a housing  904 , a part  906  requiring sterilization, and one or more radiation sensitive components  908  positioned within the housing  904 . The housing  904  may comprise packaging or an enclosure that contains the part  906  and the radiation sensitive component(s)  908 . The radiation sensitive component(s)  908  may comprise any of the electronic modules mentioned herein with respect to the radiation sensitive component(s)  808  of  FIG.  8   . The part  906  may comprise, for example a needle/sensor subassembly, and may be subjected to radiation sterilization  814  to properly sterilize the part  906  for use. 
     The assembly  900  may include a radiation shield  910  positioned external to the medical device  902  and configured to help sterilize the part  906  while preventing (impeding) propagating radiation  814  from damaging the radiation sensitive component(s)  908 . In the illustrated embodiment, the radiation shield  910  may define or otherwise provide an internal cavity  912  into which the medical device  902  may be positioned. Similar to the radiation shield  816  of  FIG.  8   , the radiation shield  910  may provide a collimator  914  that generally comprises a hole or passageway extending at least partially through the body of the radiation shield  910  and providing access into the cavity  912 . The collimator  914  may define a sterilization zone  916  that helps focus the radiation  814  toward the part  906 . The radiation shield  910  may be made of any of the materials mentioned above with respect to the radiation shield  816  to reduce or eliminate the radiation  814  from penetrating therethrough, except for at the collimator  914 , and thereby damaging the radiation sensitive component(s)  908  within the housing  904 . 
     To properly sterilize the part  906 , the radiation sterilization  814  may be directed at the medical device  902 . The collimator  914  and sterilization zone  916  may be configured to concentrate and/or focus the radiation sterilization  814  toward the part  906 , while the remaining portions of the radiation shield  910  prevent (impede) the propagating radiation  814  from damaging the radiation sensitive component(s)  908  within the housing  904 . In the illustrated embodiment, the collimator  914  and sterilization zone  916  exhibit a circular cross-sectional shape with parallel sides, but could alternatively exhibit other cross-sectional shapes including, but not limited to, conical, frustoconical, pyramidal, polygonal, or any combination thereof. 
     In some embodiments, the assembly  900  may further include the barrier shield  824  positioned within the housing  904  to help block radiation  814  (e.g., electrons) from propagating within the housing  904  toward the radiation sensitive component(s)  908 . 
       FIG.  10    is a schematic diagram of another example external sterilization assembly  1000 , according to one or more additional embodiments of the present disclosure. The external sterilization assembly  1000  (hereafter the “assembly  1000 ”) may be similar in some respects to the assembly  900  of  FIG.  15    and therefore may be best understood with reference thereto, where like numerals will refer to similar components not described again. Similar to the assembly  900 , the assembly  1000  may be designed and otherwise configured to help sterilize a medical device  1002 . In the illustrated embodiment, the medical device  1002  may comprise a sensor control device similar to the sensor control device  104  of  FIG.  1   , but could alternatively comprise any of the medical devices mentioned herein with respect to the medical device  802  of  FIG.  8   . 
     As illustrated, the medical device  1002  includes a housing  1004 , a part  1006  requiring sterilization, and one or more radiation sensitive components  1008  positioned within the housing  1004 . In the illustrated embodiment, the housing  1004  may comprise an electronics housing for a sensor control device (e.g., the sensor control device  104  of  FIG.  1   ) and the radiation sensitive component(s)  1008  may comprise any of the electronic modules mentioned herein with respect to the radiation sensitive component(s)  808  of  FIG.  8   . In some embodiments, the part  1006  may comprise a sensor (e.g., the sensor  110  of  FIG.  1   ) that extends from the housing  1004 , and may further include a sharp also requiring sterilization and used to help implant the sensor beneath the skin of a user. 
     The assembly  1000  may include a radiation shield  1010  positioned external to the medical device  1002  and configured to help sterilize the part  1006  while preventing (impeding) propagating radiation  814  from disrupting or damaging the radiation sensitive component(s)  1008 . The radiation shield  1010  may be made of any of the materials mentioned above with respect to the radiation shield  816  of  FIG.  8    to reduce or eliminate the radiation  814  from penetrating therethrough and thereby damaging the radiation sensitive component(s)  1008  within the housing  1004 . 
     In the illustrated embodiment, the radiation shield  1010  may define or otherwise provide an internal cavity  1012  into which the medical device  1002  may be positioned for sterilization. In some embodiments, the radiation shield  1010  may comprise a box and the internal cavity  1012  may be formed within the interior of the box. The radiation shield  1010  may also provide a collimator  1014  that extends at least partially through the body of the radiation shield  1010  and provides access into the cavity  1012 . The collimator  1014  may define a sterilization zone  1016  that focuses the radiation  814  toward the part  1006  for sterilization. 
     To properly sterilize the part  1006 , the radiation sterilization  814  may be directed at the medical device  1002 . The collimator  1014  and the sterilization zone  1016  may concentrate and/or focus the radiation sterilization  814  toward the part  1006 , while the remaining portions of the radiation shield  1010  prevent (impede) the propagating radiation  814  from damaging the radiation sensitive component(s)  1008  within the housing  1004 . In the illustrated embodiment, the collimator  1014  exhibits a circular cross-sectional shape with parallel sides, but could alternatively exhibit other cross-sectional shapes including, but not limited to, conical, frustoconical, pyramidal, polygonal, or any combination thereof. 
       FIG.  11    is a schematic diagram of another example external sterilization assembly  1100 , according to one or more additional embodiments of the present disclosure. The external sterilization assembly  1100  (hereafter the “assembly  1100 ”) may be similar in some respects to the assemblies  800 ,  900 , and  1000  of  FIGS.  8 ,  9 , and  10   , respectively, and therefore may be best understood with reference thereto. Similar to the assemblies  800 - 1000 , the assembly  1100  may be designed and otherwise configured to help sterilize a medical device  1102 . In the illustrated embodiment, the medical device  1102  may comprise a two piece sensor control device, but could alternatively comprise any of the medical devices mentioned herein with respect to the medical device  802 . 
     As illustrated, the medical device  1102  includes a housing  1104 , a part  1106  requiring sterilization, and one or more radiation sensitive components  1108  positioned within the housing  1104 . The radiation sensitive component(s)  1108  may comprise any of the electronic modules mentioned herein with respect to the radiation sensitive component(s)  808  of  FIG.  8   . In the illustrated embodiment, the part  1106  may comprise, for example, a needle/sensor subassembly, and may be subjected to radiation sterilization  814  to properly sterilize the part  1106  for use. 
     The assembly  1100  may include a radiation shield  1110  positioned external to the medical device  1102  and configured to help sterilize the part  1106  while preventing (impeding) propagating radiation  814  from damaging the radiation sensitive component(s)  1108 . The radiation shield  1110  may be made of any of the materials mentioned above with respect to the radiation shield  816  of  FIG.  8    to reduce or eliminate the radiation  814  from penetrating therethrough and thereby damaging the radiation sensitive component(s)  1108 . 
     In the illustrated embodiment, the radiation shield  1110  may comprise a clamshell structure including a first portion  1112   a  and a second portion  1112   b  matable (or engageable) with the first portion  1112   a . The radiation shield  1110  may also provide or otherwise define an internal cavity  1114  into which the medical device  1102  may be positioned for sterilization. In some embodiments, as illustrated, the first and second portions  1112   a,b  may cooperatively define a portion of the internal cavity  1114  such that when the first and second portions  1112   a,b  are properly mated, the internal cavity  1114  is formed. In other embodiments, however, the internal cavity  1114  may be defined wholly within the first portion  1112   a  or wholly within the second portion  1112   b.    
     In some embodiments, the assembly  1100  may further include an absorber  1116  configured to protect the medical device  1102 . In at least one embodiment, as illustrated, portions of the absorber  1116  may be provided by or otherwise form part of each of the first and second portions  1112   a,b . In such embodiments, the internal cavity  1114  may be defined, at least in part by the absorber  1116 . The absorber  1116  may be made of a material that absorbs stray radiation without causing Bremsstrahlung protons being generated. The material for the absorber  1116  may comprise, for example, any of the high-density polymers mentioned herein for the radiation shield  816  of  FIG.  8   . 
     Similar to the radiation shield  816  of  FIG.  8   , the radiation shield  1110  may provide a collimator. In the illustrated embodiment, however, the radiation shield  1110  provides or otherwise defines a first collimator  1118   a  and a second collimator  1118   b , but could alternatively include only one of the collimators  1118   a,b , without departing from the scope of the disclosure. The first collimator  1118   a  generally comprises a hole or passageway extending at least partially through the first portion  1112   a  of the radiation shield  1110 , and the second collimator  1118   b  generally comprises a hole or passageway extending at least partially through the second portion  1112   b . Each collimator  1118   a,b  provides access into the internal cavity  1114  and the collimators  1118   a,b  cooperatively define a sterilization zone  1120  that includes the internal cavity  1114  and helps focus the radiation  814  toward the part  1106  for sterilization. 
     To properly sterilize the part  1106 , the medical device  1102  may be positioned within the internal cavity  1114  and the opposing portions  1112   a,b  may be mated to encapsulate the medical device  1102 . The medical device  1102  may be situated within the sterilization zone  1120  once properly positioned within the cavity  1114 . The radiation sterilization  814  may then be directed at the medical device  1102  on opposing sides of the radiation shield  1110 , and the collimators  1118   a,b  may concentrate and/or focus the radiation sterilization  814  toward the part  1106  on opposing sides of the part  1106 . The remaining portions of the radiation shield  1110  prevent (impede) the propagating radiation  814  from damaging the radiation sensitive component(s)  1108  within the housing  1104 . In the illustrated embodiment, each collimator  1118   a,b  exhibits a conical or frustoconical cross-sectional shape, but could alternatively exhibit other cross-sectional shapes including, but not limited to, circular, pyramidal, polygonal, or any combination thereof. 
     In some embodiments, the assembly  1100  may further include one or more barrier shields  824  (two shown) positioned within the housing  1104  to help block radiation  814  (e.g., electrons) from propagating within the housing  1104  toward the radiation sensitive component(s)  1108 . 
       FIG.  12    is a schematic diagram of another example external sterilization assembly  1200 , according to one or more additional embodiments of the present disclosure. The external sterilization assembly  1200  (hereafter the “assembly  1200 ”) may be designed and otherwise configured to help sterilize a medical device  1202 , which, in the illustrated embodiment, comprises a hypodermic needle or syringe. As illustrated, the medical device  1202  includes a housing  1204  (e.g., a barrel or vial), a part  1206  requiring sterilization, and one or more radiation sensitive components  1208  positioned within the housing  1204 . In the illustrated embodiment, the radiation sensitive component  1208  may comprise a chemical solution or an analyte (e.g., an active agent, pharmaceutical, biologic, etc.) that may be sensitive to irradiation, and the part  1206  may comprise a needle designed to deliver the chemical solution. 
     In some embodiments, as illustrated, the part  1206  may be encased or otherwise surrounded by a cap  1210  (e.g., a needle cap) that encapsulates the part  1206 . Moreover, in at least one embodiment, the cap  1210  may be sealed against the housing  1204  with a sealing element  1212 , such as an O-ring or the like. The cap  1210  and the sealing element  1212  may cooperatively provide a sterile barrier system that surrounds and protects exposed portions of the part  1206  until required to be used. The part  1206  may be subjected to radiation sterilization  814  to properly sterilize the part  1206  for use. 
     The assembly  1200  may include a radiation shield  1214  positioned external to the medical device  1202  and configured to help sterilize the part  1206  while preventing (impeding) propagating radiation  814  from damaging the radiation sensitive component  1208 . As illustrated, the radiation shield  1214  may provide a collimator  1216  that generally comprises a hole or passageway extending at least partially through the body of the radiation shield  1214  and defines a sterilization zone  1218  configured to focus the radiation  814  toward the part  1206  for sterilization. In the illustrated embodiment, the part  1206  may also be received within the sterilization zone  1218 . The collimator  1216  allows transmission of the radiation  814  to impinge upon and sterilize the part  1206 , while the remaining portions of the radiation shield  1214  prevent (impede) the propagating radiation  814  from damaging the radiation sensitive component(s)  1208  within the housing  1204 . In the illustrated embodiment, the collimator  1216  is conical or frustoconical in shape, but may alternatively exhibit other cross-sectional shapes, such as polygonal, pyramidal, circular, or any combination thereof. 
     In embodiments including the cap  1210 , the body of the cap  1210  may comprise a material that permits propagation of radiation  814  therethrough to facilitate radiation sterilization of the part  1206 . Suitable materials for the cap  1210  may be the same as mentioned herein for the cap  812  of  FIG.  8   . 
     In some embodiments, the assembly  1200  may further include the barrier shield  824  positioned to help block radiation  814  (e.g., electrons) from propagating within the housing  1204  toward the radiation sensitive component  1208  (e.g., the chemical solution). In the illustrated embodiment, the barrier shield  824  may define or otherwise provide a central aperture  1220  configured to allow the radiation sensitive component  1208  to exit the housing  1204  via the part  1206  (e.g., the needle). In other embodiments, the barrier shield  824  may provide a tortuous pathway that allows the radiation sensitive component  1208  to exit the housing  1204  via the part  1206 . 
       FIG.  13    is an isometric view of an example sensor control device  1302 , according to one or more additional embodiments of the present disclosure. The sensor control device  1302  may be the same as or similar to the sensor control device  104  of  FIG.  1    and, therefore, may be used in conjunction with the sensor applicator  102  ( FIG.  1   ), which delivers the sensor control device  1302  to a target monitoring location on a user&#39;s skin. Moreover, the sensor control device  1302  may be alternately characterized as a medical device, similar to one or more of the medical devices  1402 - 1202  of  FIGS.  8 - 12    described herein. Accordingly, the sensor control device  1302  may also require proper sterilization prior to being used. 
     As illustrated, the sensor control device  1302  includes an electronics housing  1304  that is generally disc-shaped and may have a circular cross-section. In other embodiments, however, the electronics housing  1304  may exhibit other cross-sectional shapes, such as ovoid (e.g., pill-shaped), a squircle, or polygonal, without departing from the scope of the disclosure. The electronics housing  1304  may be configured to house or otherwise contain various electronic components used to operate the sensor control device  1302 . 
     The electronics housing  1304  may include a shell  1306  and a mount  1308  that is matable with the shell  1306 . The shell  1306  may be secured to the mount  1308  via a variety of ways, such as a snap fit engagement, an interference fit, sonic welding, one or more mechanical fasteners (e.g., screws), or any combination thereof. In some cases, the shell  1306  may be secured to the mount  1308  such that a sealed interface therebetween is generated. In such embodiments, a gasket or other type of seal material may be positioned at or near the outer diameter (periphery) of the shell  1306  and the mount  1308 , and securing the two components together may compress the gasket and thereby generate a sealed interface. In other embodiments, an adhesive may be applied to the outer diameter (periphery) of one or both of the shell  1306  and the mount  1308 . The adhesive secures the shell  1306  to the mount  1308  and provides structural integrity, but may also seal the interface between the two components and thereby isolate the interior of the electronics housing  1304  from outside contamination. 
     In the illustrated embodiment, the sensor control device  1302  may further include a plug assembly  1310  that may be coupled to the electronics housing  1304 . The plug assembly  1310  may include a sensor module  1312  (partially visible) interconnectable with a sharp module  1314  (partially visible). The sensor module  1312  may be configured to carry and otherwise include a sensor  1316  (partially visible), and the sharp module  1314  may be configured to carry and otherwise include a sharp  1318  (partially visible) used to help deliver the sensor  1316  transcutaneously under a user&#39;s skin during application of the sensor control device  1302 . The sharp module  1314  may include a sharp hub  1320  that carries the sharp  1318 . 
     As illustrated, corresponding portions of the sensor  1316  and the sharp  1318  extend from the electronics housing  1304  and, more particularly, from the bottom of the mount  1308 . The exposed portion of the sensor  1316  (alternately referred to as the “tail”) may be received within a hollow or recessed portion of the sharp  1318 . The remaining portions of the sensor  1316  are positioned within the interior of the electronics housing  1304 . 
       FIG.  14 A  is a side view of the sensor applicator  102  of  FIG.  1   . As illustrated, the sensor applicator  102  includes a housing  1402  and an applicator cap  1404  that may be removably coupled to the housing  1402 . In some embodiments, the applicator cap  1404  may be threaded to the housing  1402  and include a tamper ring  1406 . Upon rotating (e.g., unscrewing) the applicator cap  1404  relative to the housing  1402 , the tamper ring  1406  may shear and thereby free the applicator cap  1404  from the sensor applicator  102 . Once the applicator cap  1404  is removed, a user may then use the sensor applicator  102  to position the sensor control device  1302  ( FIGS.  13  and  14 B ) at a target monitoring location on the user&#39;s body. 
     In some embodiments, the applicator cap  1404  may be secured to the housing  1402  via a sealed engagement to protect the internal components of the sensor applicator  102 . In at least one embodiment, for example, an O-ring or another type of sealing gasket may seal an interface between the housing  1402  and the applicator cap  1404 . The O-ring or sealing gasket may be a separate component part or alternatively molded onto one of the housing  1402  and the applicator cap  1404 . 
       FIG.  14 B  is a cross-sectional side view of the sensor applicator  102 . As illustrated, the sensor control device  1302  may be received within the sensor applicator  102  and the applicator cap  1404  may be coupled to the sensor applicator  102  to secure the sensor control device  1302  therein. The sensor control device  1302  may include one or more radiation sensitive components  1408  arranged within the electronics housing  1304 . The radiation sensitive component  1408  can include an electronic component or module such as, but not limited to, a data processing unit, a resistor, a transistor, a capacitor, an inductor, a diode, a switch, or any combination thereof. The data processing unit may comprise, for example, an application specific integrated circuit (ASIC) configured to implement one or more functions or routines associated with operation of the sensor control device  1302 . In operation, the data processing unit may perform data processing functions, such as filtering and encoding of data signals corresponding to a sampled analyte level of the user. The data processing unit may also include or otherwise communicate with an antenna for communicating with the reader device  106  ( FIG.  1   ). 
     In the illustrated embodiment, a cap fill  1410  may be positioned within the applicator cap  1404  and may generally help support the sensor control device  1302  within the sensor applicator  102 . In one or more embodiments, the cap fill  1410  may comprise an integral part or extension of the applicator cap  1404 , such as being molded with or overmolded onto the applicator cap  1404 . In other embodiments, the cap fill  1410  may comprise a separate structure fitted within or otherwise attached to the applicator cap  1404 , without departing from the scope of the disclosure. 
     The sensor control device  1302  and, more particularly, the distal ends of the sensor  1316  and the sharp  1318  extending from the bottom of the electronics housing  1304 , may be sterilized while positioned within the sensor applicator  102 . More specifically, the fully assembled sensor control device  1302  may be subjected to radiation sterilization  1412 , which may be similar to the radiation sterilization  814  of  FIGS.  8 - 12   . The radiation sterilization  1412  may be delivered either through continuous processing irradiation or through pulsed beam irradiation. In pulsed beam irradiation, the beam of radiation sterilization  1412  is focused at a target location and the component part or device to be sterilized is moved to the target location at which point the irradiation is activated to provide a directed pulse of radiation. The radiation sterilization  1412  is then turned off, and another component part or device to be sterilized is moved to the target location and the process is repeated. 
     According to the present disclosure, an external sterilization assembly  1414  may be used to help focus the radiation  1412  in sterilizing the distal ends of the sensor  1316  and the sharp  1318 , while simultaneously preventing (impeding) propagating radiation  1412  from damaging the radiation sensitive component  1408 . As illustrated, the external sterilization assembly  1414  (hereafter the “assembly  1414 ”) may include a radiation shield  1416  positioned at least partially external to the sensor applicator  102 . The radiation shield  1416  may provide or define an external collimator  1418  configured to help focus the radiation  1412  (e.g., beams, waves, energy, etc.) toward the components to be sterilized. More specifically, the external collimator  1418  allows transmission of the radiation  1412  to impinge upon and sterilize the sensor  1316  and the sharp  1318 , but prevent the radiation  1412  from damaging the radiation sensitive component  1408  within the electronics housing  1304 . 
     In the illustrated embodiment, the external collimator  1418  is designed to align with an internal collimator  1420  defined by the cap fill  1410 . Similar to the external collimator  1418 , the internal collimator  1420  may help focus the radiation  1412  toward the components to be sterilized. As illustrated, the cap fill  1410  may define a radial shoulder  1422  sized to receive and otherwise mate with an end of the radiation shield  1416 , and the external collimator  1418  transitions to the internal collimator  1420  at the radial shoulder  1422 . In some embodiments, the transition between the external and internal collimators  1418 ,  1420  may be continuous, flush, or smooth. In other embodiments, however, the transition may be discontinuous or stepped, without departing from the scope of the disclosure. 
     The external and internal collimators  1418 ,  1420  may cooperatively define a sterilization zone  1424  that focuses the radiation  1412  and into which the distal ends of the sensor  1316  and the sharp  1318  may be positioned. The propagating radiation  1412  may traverse the sterilization zone  1424  to impinge upon and sterilize the sensor  1316  and the sharp  1318 . However, the cap fill  1410  and the radiation shield  1416  may each be made of materials that substantially prevent the radiation  1412  from penetrating the inner wall(s) of the sterilization zone  1424  and thereby damaging the radiation sensitive component  1408  within the housing  1304 . In other words, the cap fill  1410  and the radiation shield  1416  may each be made of materials having a density sufficient to absorb the dose of the beam energy being delivered. In some embodiments, for example, one or both of the cap fill  1410  and the radiation shield  1416  may be made of a material that has a mass density greater than 0.9 grams per cubic centimeter (g/cc). In other embodiments, however, the mass density of a suitable material may be less than 0.9 g/cc, without departing from the scope of the disclosure. Suitable materials for the cap fill  1410  and the radiation shield  1416  include, but are not limited to, a high-density polymer, (e.g., polyethylene, polypropylene, polystyrene, polytetrafluoroethylene, etc.), a metal (e.g., lead, stainless steel, aluminum, etc.), any combination thereof, or any material having a mass density greater than 0.9 g/cc. In at least one embodiment, the cap fill  1410  may be made of machined or 3D printed polypropylene and the radiation shield  1416  may be made of stainless steel. 
     In some embodiments, the design of the sterilization zone  1424  may be altered so that one or both of the cap fill  1410  and the radiation shield  1416  may be made of a material that has a mass density less than 0.9 g/cc but may still operate to prevent the radiation sterilization  1412  from damaging the radiation sensitive component  1408 . In such embodiments, the size (e.g., length) of the sterilization zone  1424  may be increased such that the propagating electrons from the radiation sterilization  1412  are required to pass through a larger amount of material before potentially impinging upon the radiation sensitive component  1408 . The larger amount of material may help absorb or dissipate the dose strength of the radiation  1412  such that it becomes harmless to the sensitive electronics. In other embodiments, however, the converse may equally be true. More specifically, the size (e.g., length) of the sterilization zone  1424  may be decreased as long as the material for the cap fill  1410  and/or the radiation shield  1416  exhibits a large enough mass density. 
     The sterilization zone  1424  defined by the external and internal collimators  1418 ,  1420  can exhibit any suitable cross-sectional shape necessary to properly focus the radiation  1412  on the sensor  1316  and the sharp  1318  for sterilization. In the illustrated embodiment, for example, the external collimator  1418  is conical or frustoconical in shape, but the internal collimator  1420  exhibits a circular cross-sectional shape with parallel sides. In other embodiments, however, one or both of the external and internal collimators  1418 ,  1420  may exhibit a polygonal cross-sectional shape, such as cubic or rectangular (e.g., including parallelogram), without departing from the scope of the disclosure. 
     In the illustrated embodiment, the sterilization zone  1424  provides a first aperture  1426   a  defined by the external collimator  1418  and a second aperture  1426   b  defined by the internal collimator  1420 , where the first and second apertures  1426   a,b  are located at opposing ends of the sterilization zone  1424 . The first aperture  1426   a  permits the radiation  1412  to enter the sterilization zone  1424 , and the second aperture  1426   b  provides a location where radiation  1412  can impact the sensor  1316  and the sharp  1318 . In the illustrated embodiment, the second aperture  1426   b  also provides a location where the sensor  1316  and the sharp  1318  may be received into the sterilization zone  1424 . 
     The diameter of the first aperture  1426   a  may be larger than the diameter of the second aperture  1426   b . In such embodiments, for example, the size of the first aperture  1426   a  may range between about 5.0 mm and about 16.0 mm, and the size of the second aperture  1426   b  may range between about 0.5 mm and about 3.0 mm. The respective diameters of the first and second apertures  1426   a,b , however, may be greater or less than the ranges provided herein, without departing from the scope of the disclosure, and depending on the application. Indeed, the diameters of the first and second apertures  1426   a,b  need only be large enough to allow a sufficient dose of radiation to impinge upon the sensor  1316  and the sharp  1318 . In some embodiments, the sterilization zone  1424  defined by the external and internal collimators  1418  may be substantially cylindrical and otherwise exhibit a circular or polygonal cross-section. In such embodiments, the first and second apertures  1426   a,b  may exhibit identical diameters and the walls of the sterilization zone  1424  may be substantially parallel between the first and second ends of the sterilization zone  1424 . 
     In some embodiments, a cap seal  1428  (shown in dashed lines) may be arranged at the interface between the cap fill  1410  and the radiation shield  1416 . The cap seal  1428  may comprise a radiation permeable microbial barrier. In some embodiments, for example, the cap seal  1428  may be made of a synthetic material (e.g., a flash-spun high-density polyethylene fiber), such as TYVEK® available from DuPont®. The cap seal  1428  may seal off a portion of the sterilization zone  1424  to help form part of a sealed region  1430  configured to isolate the sensor  1316  and the sharp  1318  from external contamination. 
     The sealed region  1430  may include (encompass) select portions of the interior of the electronics housing  1304  and the sterilization zone  1424 . In one or more embodiments, the sealed region  1430  may be defined and otherwise formed by at least the cap seal  1428 , a first or “top” seal  1432   a , and a second or “bottom” seal  1432   b . The cap seal  1428  and the top and bottom seals  1432   a,b  may each create corresponding barriers at their respective sealing locations, thereby allowing the sterilization zone  1424  containing the sensor  1316  and the sharp  1318  to be terminally sterilized. 
     The top seal  1432   a  may be arranged to seal the interface between the sharp hub  1320  and the top of the electronics housing  1304  (i.e., the shell  1306  of  FIG.  13   ) and thereby prevent contaminants from migrating into the interior of the electronics housing  1304 . In some embodiments, the top seal  1432   a  may form part of the sharp hub  1320 , such as being overmolded onto the sharp hub  1320 . In other embodiments, however, the top seal  1432   a  may form part of or be overmolded onto the top surface of the shell  1306 . In yet other embodiments, the top seal  1432   a  may comprise a separate structure, such as an O-ring or the like, that interposes the sharp hub  1320  and the top surface of the shell  1306 , without departing from the scope of the disclosure. 
     The bottom seal  1432   b  may be arranged to seal the interface between the cap fill  1410  and the bottom of electronics housing  1304  (i.e., the mount  1308  of  FIG.  13   ). The bottom seal  1432   b  may prevent contaminants from migrating into the sterilization zone  1424  and from migrating into the interior of the electronics housing  1304 . In some embodiments, the bottom seal  1432   b  may form part of the cap fill  1410 , such as being overmolded onto the top of the cap fill  1410 . In other embodiments, the bottom seal  1432   b  may form part of or be overmolded onto the bottom of the mount  1308 . In yet other embodiments, the bottom seal  1432   b  may comprise a separate structure, such as an O-ring or the like, that interposes the cap fill  1410  and the bottom of the mount  1308 , without departing from the scope of the disclosure. 
     Upon loading the sensor control device  1302  into the sensor applicator  102  and securing the applicator cap  1404  to the sensor applicator  102 , the top and bottom seals  1432   a,b  may compress and generate corresponding sealed interfaces. The top and bottom seals  1432   a,b  may be made of a variety of materials capable of generating a sealed interface between opposing structures. Suitable materials include, but are not limited to, silicone, a thermoplastic elastomer (TPE), polytetrafluoroethylene (e.g., TEFLON®), or any combination thereof. 
     It is noted that, while the sensor  1316  and the sharp  1318  extend from the bottom of the electronics housing  1304  and into the sterilization zone  1424  generally concentric with a centerline of the sensor applicator  102  and the applicator cap  1404 , it is contemplated herein to have an eccentric arrangement. More specifically, in at least one embodiment, the sensor  1316  and the sharp  1318  may extend from the bottom of the electronics housing  1304  eccentric to the centerline of the sensor applicator  102  and the applicator cap  1404 . In such embodiments, the external and internal collimators  1418 ,  1420  may be re-designed and otherwise configured such that the sterilization zone  1424  is also eccentrically positioned to receive the sensor  1316  and the sharp  1318 , without departing from the scope of the disclosure. 
     In some embodiments, the external sterilization assembly  1414  may further include a sterilization housing or “pod”  1434  coupled to or forming part of the radiation shield  1416 . The sterilization pod  1434  provides and otherwise defines a chamber  1436  sized to receive all or a portion of the sensor applicator  102 . Once properly seated (received) within the sterilization pod  1434 , the sensor applicator  102  may be subjected to the radiation sterilization  1412  to sterilize the sensor  1316  and the sharp  1318 . The sterilization pod  1434  may be made of any of the materials mentioned herein for the radiation shield  1416  to help prevent the radiation  1412  from propagating through the walls of the sterilization pod  1434 . 
     In some embodiments, the radiation shield  1416  may be removably coupled to the sterilization pod  1434  using one or more mechanical fasteners  1438  (one shown), but could alternatively be removably coupled via an interference fit, a snap fit engagement, etc. Removably coupling the radiation shield  1416  to the sterilization pod  1434  enables the radiation shield  1416  to be interchangeable with differently designed (sized) shields to fit particular sterilization applications for varying types and designs of the sensor applicator  102 . Accordingly, the sterilization pod  1434  may comprise a universal mount that allows the radiation shield  1416  to be interchanged with other shield designs having different parameters for the external collimator  1418 , as needed. 
     In some embodiments, the external sterilization assembly  1414  may further include a mounting tray  1440  coupled to or forming part of the sterilization pod  1434 . The sterilization pod  1434  may be removably coupled to the mounting tray  1440  using, for example, one or more mechanical fasteners  1442  (one shown). The mounting tray  1440  may provide or define a central aperture  1444  sized to receive the sensor applicator  102  and alignable with the chamber  1436  to enable the sensor applicator  102  to enter the chamber  1436 . As described below, in some embodiments, the mounting tray  1440  may define a plurality of central apertures  1444  for receiving a corresponding plurality of sensor applicators for sterilization. 
       FIG.  15    is a cross-sectional side view of the sensor applicator  102  and another example embodiment of the external sterilization assembly  1414 , according to one or more additional embodiments. As illustrated, the sensor control device  1302  is again received within the sensor applicator  102  and the applicator cap  1404  is coupled to the housing  1402  to secure the sensor control device  1302  therein. 
     In the illustrated embodiment, the applicator cap  1404  may be inverted and may define or otherwise provide a cap post  1502  sized to receive the distal ends of the sensor  1316  and the sharp  1318  extending from the bottom of the electronics housing  1304 . The cap post  1502  helps provide a portion of the sealed region  1430  configured to isolate the sensor  1316  and the sharp  1318  from external contamination. In the illustrated embodiment, the sealed region  1430  may be defined and otherwise formed by the cap post  1502  and the top and bottom seals  1432   a,b , which create corresponding barriers at their respective sealing locations. The top seal  1432   a  may again be arranged to seal the interface between the sharp hub  1320  and the top of the electronics housing  1304  (i.e., the shell  1306  of  FIG.  13   ), and the bottom seal  1432   b  may be arranged to seal an interface between the applicator cap  1404  and the bottom of electronics housing  1304  (i.e., the mount  1308  of  FIG.  13   ). In some embodiments, the bottom seal  1432   b  may interpose the cap post  1502  and the bottom of electronics housing  1304 . 
     In the illustrated embodiment, the radiation shield  1416  may be positioned external to the sensor applicator  102  and may extend into the inverted portion of the applicator cap  1404 . The external collimator  1418  provided by the radiation shield  1416  defines a sterilization zone  1504  configured to focus the radiation  1412  toward the sensor  1316  and the sharp  1318 . In the illustrated embodiment, the cap post  1502  and portions of the sensor  1316  and the sharp  1318  positioned within the cap post  1502  extend into the sterilization zone  1504 . Propagating radiation  1412  may traverse the sterilization zone  1504  to sterilize the sensor  1316  and the sharp  1318  positioned within the cap post  1502 . As indicated above, however, the radiation shield  1416  may be made of a material that substantially prevents the radiation  1412  from penetrating the wall(s) of the sterilization zone  1504  and thereby damaging the radiation sensitive component  1408  within the housing  1304 . 
     In the illustrated embodiment, the external collimator  1418  defines a first aperture  1506   a  at a first end of the sterilization zone  1504  and a second aperture  1506   b  at the second end of the sterilization zone  1504 . The first aperture  1506   a  permits the radiation  1412  to enter the sterilization zone  1504 , and the second aperture  1506   b  provides a location where radiation  1412  is focused toward the sensor  1316  and the sharp  1318 . The second aperture  1506   b  may also provide a location where the sensor  1316  and the sharp  1318  positioned within the cap post  1502  may be received into the sterilization zone  1504 . 
     As illustrated, the external collimator  1418  and associated sterilization zone  1504  are conical or frustoconical in shape, and the diameter of the first aperture  1506   a  is larger than the diameter of the second aperture  1506   b . The size of the first aperture  1506   a  may range between about 5.0 mm and about 16.0 mm, and the size of the second aperture  1506   b  may range between about 0.5 mm and about 3.0 mm, but could alternatively be greater or less than the provided ranges, without departing from the scope of the disclosure. Indeed, the sizes of the apertures  1506   a,b  may vary depending on the scale of the device. In other embodiments, however, the external collimator  1418  and associated sterilization zone  1504  may be substantially cylindrical and otherwise exhibit a circular or polygonal cross-section where the first and second apertures  1506   a,b  exhibit substantially identical diameters and the walls of the sterilization zone  1504  are substantially parallel. 
       FIG.  16    is a cross-sectional side view of the sensor applicator  102  and another example embodiment of the external sterilization assembly  1414 , according to one or more additional embodiments. As illustrated, the sensor control device  1302  is again received within the sensor applicator  102  and the applicator cap  1404  is coupled to the housing  1402  to secure the sensor control device  1302  therein. 
     In the illustrated embodiment, the applicator cap  1404  may again be inverted and may define or otherwise provide a cap post  1602  sized to receive the distal ends of the sensor  1316  and the sharp  1318  extending from the bottom of the electronics housing  1304 . Moreover, the radiation shield  1416  may be positioned external to the sensor applicator  102  and may extend into the inverted portion of the applicator cap  1404 . More specifically, the radiation shield  1416  may extend into the inverted portion of the applicator cap  1404  and to the bottom of the cap post  1602 . Unlike the cap post  1502  of  FIG.  15   , however, the bottom of the cap post  1602  may be open ended. In some embodiments, a cap seal  1604  may be arranged at the interface between the cap post  1602  and the radiation shield  1416  to seal off the open end of the cap post  1602 . The cap seal  1604  may be similar to the cap seal  1428  of  FIG.  14 B , and therefore will not be described again. 
     In some embodiments, a cap fill  1606  may be positioned within the applicator cap  1404 . In one or more embodiments, the cap fill  1606  may comprise an integral part or extension of the applicator cap  1404 , such as being molded with or overmolded onto the applicator cap  1404 . In other embodiments, the cap fill  1606  may comprise a separate structure fitted within or otherwise attached to the applicator cap  1404 , without departing from the scope of the disclosure. The cap fill  1606  may also provide or otherwise define an internal collimator  1608  that may help focus the radiation  1412  toward the components to be sterilized. In at least one embodiment, as illustrated, the cap post  1602  may be received within the internal collimator  1608 . 
     The external and internal collimators  1418 ,  1608  may cooperatively define a sterilization zone  1610  that focuses the radiation  1412  toward the sensor  1316  and the sharp  1318 . The propagating radiation  1412  may traverse the sterilization zone  1610  to impinge upon and sterilize the sensor  1316  and the sharp  1318 . However, the cap fill  1606  and the radiation shield  1416  may each be made of any of the materials mentioned herein that substantially prevent the radiation  1412  from penetrating the inner wall(s) of the sterilization zone  1610  and thereby damaging the radiation sensitive component  1408  within the housing  1304 . In at least one embodiment, the cap fill  1606  may be made of machined or 3D printed polypropylene and the radiation shield  1416  may be made of stainless steel. 
     The external and internal collimators  1418 ,  1608  can exhibit any suitable cross-sectional shape necessary to properly focus the radiation  1412  toward the sensor  1316  and the sharp  1318  for sterilization. In the illustrated embodiment, for example, the external collimator  1418  is conical or frustoconical in shape, and the internal collimator  1608  is substantially cylindrical with internal walls that are substantially parallel. In other embodiments, however, the external and internal collimators  1418 ,  1608  may exhibit other cross-sectional shapes, without departing from the scope of the disclosure. 
     In the illustrated embodiment, the external collimator  1418  defines a first aperture  1612   a  that permits the radiation  1412  to enter the sterilization zone  1610  and a second aperture  1612   b  positioned at or near the bottom opening to the cap post  1602  to focus the radiation  1412  at the sensor  1316  and the sharp  1318  positioned within the cap post  1602 . The diameter of the first aperture  1612   a  is larger than the diameter of the second aperture  1612   b  and, as with prior embodiments, the size of the first aperture  1612   a  may range between about 5.0 mm and about 16.0 mm, and the size of the second aperture  1612   b  may range between about 0.5 mm and about 3.0 mm. In the illustrated embodiment, the external collimator  1418  funnels the electrons of the radiation  1412  toward the bottom opening to the cap post  1602  and amplifies the electrons at the sensor  1316  and the sharp  1318 . 
     The cap seal  1604  may be arranged at the interface between the radiation shield  1416  and the cap post  1602  and/or the cap fill  1606 . The cap seal  1604  may seal off a portion of the sterilization zone  1610  to help form part of the sealed region  1430  configured to isolate the sensor  1316  and the sharp  1318  from external contamination. The sealed region  1430  may include (encompass) select portions of the interior of the electronics housing  1304  and the sterilization zone  1610 . In the illustrated embodiment, the sealed region  1430  may be defined and otherwise formed by the cap post  1602  and the top and bottom seals  1432   a,b , which create corresponding barriers at their respective sealing locations. The bottom seal  1432   b  may be arranged to seal an interface between the applicator cap  1404  and the bottom of electronics housing  1304  (i.e., the mount  1308  of  FIG.  13   ). 
       FIGS.  17 A and  17 B  are partially exploded isometric top and bottom views, respectively, of one example of the external sterilization assembly  1414 , according to one or more embodiments. In at least one embodiment, the assembly  1414  may be designed and otherwise configured to accommodate and help sterilize a plurality of sensor applicators  102  (i.e., with the sensor control devices positioned therein). In the illustrated embodiment, the mounting tray  1440  defines a plurality of central apertures  1444  ( FIG.  17 A ), and a plurality of sterilization pods  1434  may be aligned with the central apertures  1444  and coupled to the mounting tray  1440 . The sensor applicators  102  may be received within the sterilization pods  1434  via the central apertures  1444 , and each sterilization pod  1434  may have a corresponding shield  1416  ( FIG.  17 B ) coupled thereto or otherwise forming part thereof. 
     In some embodiments, the assembly  1414  may further include a cover  1702  matable with the mounting tray  1440 . The cover  1702  may include or define a plurality of apertures  1106  ( FIG.  17 B ) sized to receive the tops of the sensor applicators  102  when the cover  1702  is placed on top of the mounting tray  1440 . In some embodiments, the cover  1702  may be made of any of the materials mentioned herein for the radiation shield  1416  to help prevent the radiation sterilization from propagating through the walls of the assembly  1414 . With the cover  1702  mated with the mounting tray  1414 , the sensor applicators  102  may be encapsulated or otherwise encased within the assembly  1414 . 
     Embodiments disclosed herein include: 
     D. An external sterilization assembly that includes a radiation shield positionable external to a medical device having a part requiring sterilization and a radiation sensitive component, and a collimator defined by the radiation shield and alignable with the part requiring sterilization, wherein the collimator focuses radiation from a radiation sterilization process toward the part requiring sterilization and the radiation shield prevents the radiation from damaging the radiation sensitive component. 
     E. An external sterilization assembly that includes a radiation shield positionable external to a sensor applicator that includes a housing, a cap coupled to the housing, and a sensor control device positioned within the housing, wherein the sensor control device includes an electronics housing, a radiation sensitive component arranged within the electronics housing, and a sensor and a sharp extending from the electronics housing. The external sterilization assembly further including an external collimator defined by the radiation shield and alignable with the sensor and the sharp, wherein the external collimator focuses radiation from a radiation sterilization process toward the sensor and the sharp and the radiation shield prevents the radiation from damaging the radiation sensitive component. 
     F. A method including arranging a radiation shield external to a sensor applicator having a housing, a cap coupled to the housing, and a sensor control device positioned within the housing, wherein the sensor control device includes an electronics housing, a radiation sensitive component arranged within the electronics housing, and a sensor and a sharp extending from the electronics housing. The method further including focusing radiation from a radiation sterilization process toward the sensor and the sharp with an external collimator defined by the radiation shield, and preventing the radiation from damaging the radiation sensitive component with the radiation shield. 
     Each of embodiments D, E, and F may have one or more of the following additional elements in any combination: Element 1: wherein the radiation shield is made of a material selected from the group consisting of a high-density polymer, a metal, and any combination thereof. Element 2: wherein the radiation sensitive component is selected from the group consisting of an electronic module, a chemical solution, and any combination thereof. Element 3: wherein the collimator comprises a cross-sectional shape selected from the group consisting of conical, frustoconical, pyramidal, circular, cubic, rectangular, and any combination thereof. Element 4: further comprising a cap that encapsulates the part requiring sterilization and provides a sealed barrier. Element 5: wherein the radiation shield defines an internal cavity that receives the medical device, and the collimator focuses the radiation into the internal cavity. 
     Element 6: wherein the radiation shield is made of a material selected from the group consisting of a high-density polymer, a metal, and any combination thereof. Element 7: wherein the external collimator comprises a cross-sectional shape selected from the group consisting of conical, frustoconical, pyramidal, circular, cubic, rectangular, and any combination thereof. Element 8: further comprising a sterilization pod defining a chamber that receives at least a portion of the sensor applicator, wherein the radiation shield is removably coupled to the sterilization pod. Element 9: further comprising a mounting tray that defines a central aperture alignable with the chamber and sized to receive the sensor applicator, and a cover matable with the mounting tray to encase the sensor applicator. Element 10: wherein the external collimator is alignable with an internal collimator defined by a cap fill positioned within the cap, and wherein the external and internal collimators cooperatively define a sterilization zone into which the sensor and the sharp are received. Element 11: wherein the external collimator comprises a cross-sectional shape selected from the group consisting of conical, frustoconical, pyramidal, circular, cubic, rectangular, and any combination thereof. Element 12: further comprising a cap seal arranged at an interface between the external and internal collimators. Element 13: wherein the cap is inverted and provides a cap post that receives the sensor and the sharp. Element 14: wherein the external collimator and the cap post cooperatively define a sterilization zone and the sensor and the sharp positioned within the cap post extend into the sterilization zone. 
     Element 15: wherein arranging the radiation shield external to the sensor applicator comprises positioning the sensor applicator within a chamber defined by a sterilization pod, the radiation shield being removably coupled to the sterilization pod. Element 16: wherein positioning the sensor applicator within the chamber defined by the sterilization pod further comprise extending the sensor applicator through a central aperture defined by a mounting tray and aligned with the chamber, positioning a cover on the mounting tray and thereby encasing the sensor applicator, and undertaking the radiation sterilization process while the sensor applicator is encased by the cover. Element 17: wherein the external collimator comprises a cross-sectional shape selected from the group consisting of conical, frustoconical, pyramidal, circular, cubic, rectangular, and any combination thereof. 
     By way of non-limiting example, exemplary combinations applicable to D, E, and F include: Element 8 with Element 9; Element 10 with Element 11; Element 10 with Element 12; Element 13 with Element 14; and Element 15 with Element 16. 
     Hybrid Sterilization Assemblies 
     Referring again briefly, to  FIG.  1   , prior to being delivered to an end user, the sensor control device  104  must be sterilized to render the product free from viable microorganisms. The sensor  110  is commonly sterilized using radiation sterilization, such as electron beam (“e-beam”) irradiation. Radiation sterilization, however, can damage the electronic components within the sensor control device  104 , which are commonly sterilized via gaseous chemical sterilization (e.g., using ethylene oxide). Gaseous chemical sterilization, however, can damage the enzymes or other chemistry and biologics included on the sensor  110 . 
     In the past, this sterilization incompatibility has been circumvented by separating the sensor  110  and the electronic components and sterilizing each individually. This approach, however, requires additional parts, packaging, process steps, and final assembly by the user, which introduces a possibility of user error. According to the present disclosure, the sensor control device  104 , or any device requiring terminal sterilization, may be properly sterilized using external sterilization assemblies designed to focus sterilizing radiation (e.g., beams, waves, energy, etc.) toward component parts requiring sterilization, while simultaneously preventing the propagating radiation from disrupting or damaging sensitive electronic components. 
       FIG.  18    is an isometric view of an example sensor control device  1802 , according to one or more embodiments of the present disclosure. The sensor control device  1802  may be the same as or similar to the sensor control device  104  of  FIG.  1    and, therefore, may be used in conjunction with the sensor applicator  102  ( FIG.  1   ), which delivers the sensor control device  1802  to a target monitoring location on a user&#39;s skin. Accordingly, the sensor control device  1802  also requires proper sterilization prior to being used. 
     As illustrated, the sensor control device  1802  includes an electronics housing  1804  that is generally disc-shaped and may have a circular cross-section. In other embodiments, however, the electronics housing  1804  may exhibit other cross-sectional shapes, such as ovoid (e.g., pill- or egg-shaped), a squircle, polygonal, or any combination thereof, without departing from the scope of the disclosure. The electronics housing  1804  may be configured to house or otherwise contain various electronic components used to operate the sensor control device  1802 . 
     The electronics housing  1804  may include a shell  1806  and a mount  1808  that is matable with the shell  1806 . The shell  1806  may be secured to the mount  1808  via a variety of ways, such as a snap fit engagement, an interference fit, sonic or laser welding, one or more mechanical fasteners (e.g., screws), or any combination thereof. In some cases, the shell  1806  may be secured to the mount  1808  such that a sealed interface is generated therebetween. In such embodiments, a gasket or other type of seal material may be positioned at or near the outer diameter (periphery) of the shell  1806  and the mount  1808 , and securing the two components together may compress the gasket and thereby generate a sealed interface. In other embodiments, an adhesive may be applied to the outer diameter (periphery) of one or both of the shell  1806  and the mount  1808 . The adhesive secures the shell  1806  to the mount  1808  and provides structural integrity, but may also seal the interface between the two components and thereby isolate the interior of the electronics housing  1804  from outside contamination. 
     In the illustrated embodiment, the sensor control device  1802  may optionally include a plug assembly  1810  that may be coupled to the electronics housing  1804 . The plug assembly  1810  may include a sensor module  1812  (partially visible) interconnectable with a sharp module  1814  (partially visible). The sensor module  1812  may be configured to carry and otherwise include a sensor  1816  (partially visible), and the sharp module  1814  may be configured to carry and otherwise include an introducer or sharp  1818  (partially visible) used to help deliver the sensor  1816  transcutaneously under a user&#39;s skin during application of the sensor control device  1802 . In the illustrated embodiment, the sharp module  1814  includes a sharp hub  1820  that carries the sharp  1818 . 
     As illustrated, corresponding portions of the sensor  1816  and the sharp  1818  extend distally from the electronics housing  1804  and, more particularly, from the bottom of the mount  1808 . In at least one embodiment, the exposed portion of the sensor  1816  (alternately referred to as the “tail”) may be received within a hollow or recessed portion of the sharp  1818 . The remaining portions of the sensor  1816  are positioned within the interior of the electronics housing  1804 . 
       FIG.  19 A  is a side view of the sensor applicator  102  of  FIG.  1   . As illustrated, the sensor applicator  102  includes a housing  1902  and an applicator cap  1904  that may be removably coupled to the housing  1902 . In some embodiments, the applicator cap  1904  may be threaded to the housing  1902  and include a tamper ring  1906 . Upon rotating (e.g., unscrewing) the applicator cap  1904  relative to the housing  1902 , the tamper ring  1906  may shear and thereby free the applicator cap  1904  from the sensor applicator  102 . Once the applicator cap  1904  is removed, a user may then use the sensor applicator  102  to position the sensor control device  1802  ( FIG.  18   ) at a target monitoring location on the user&#39;s body. 
       FIG.  19 B  is a partial cross-sectional side view of the sensor applicator  102 . As illustrated, the sensor control device  1802  may be received within the sensor applicator  102  and the applicator cap  1904  may be coupled to the housing  1902  to secure the sensor control device  1802  within. The sensor control device  1802  may include one or more radiation sensitive components  1908  arranged within the electronics housing  1804 . The radiation sensitive component  1908  can include an electronic component or module such as, but not limited to, a data processing unit, a resistor, a transistor, a capacitor, an inductor, a diode, a switch, or any combination thereof. The data processing unit may comprise, for example, an application specific integrated circuit (ASIC) configured to implement one or more functions or routines associated with operation of the sensor control device  1802 . In operation, the data processing unit may perform data processing functions, such as filtering and encoding of data signals corresponding to a sampled analyte level of the user. The data processing unit may also include or otherwise communicate with an antenna for communicating with the reader device  106  ( FIG.  1   ). 
     In the illustrated embodiment, an applicator insert  1910  may be positioned within the applicator cap  1904  and may generally help support the sensor control device  1802  within the sensor applicator  102 . In one embodiment, the applicator insert  1910  may comprise an integral part or extension of the applicator cap  1904 , such as being molded with or overmolded onto the applicator cap  1904 . In other embodiments, the applicator insert  1910  may comprise a separate structure fitted within or otherwise attached to the applicator cap  1904 , without departing from the scope of the disclosure. In such embodiments, for example, screwing the applicator cap  1904  onto the housing  1908  may progressively advance an inner surface  1912  of the applicator insert  1910  into axial and/or radial engagement with a bottom edge, surface or portion of the applicator insert  1910  to thereby axially secure the applicator insert  1910  within the applicator cap  1904 . 
     The sensor applicator  102  may further include a sheath  1914  and, in some embodiments, the applicator insert  1910  may engage the sheath  1914  to rotationally fix the applicator insert  1910  within the applicator cap  1904 . More specifically, the applicator insert  1910  may provide or otherwise define one or more radial alignment features  1916  (one shown) matable with a corresponding groove or slot  1918  defined in the sheath  1914 . The radial alignment feature  1916  may comprise, for example, a rail, a flag, a tab, a protrusion, or the like extending from the main body of the applicator insert  1910  and may mate with the slot  1918  by sliding the radial alignment feature  1916  longitudinally into the slot  1918 , for example. Mating engagement between the radial alignment feature  1916  and the slot  1918  may also help angularly (rotationally) orient the applicator insert  1910  relative to the sensor control device  1802 . As will be appreciated, however, the matable structures may alternatively be reversed, where the radial alignment feature  1916  is instead provided on the sheath  1914  and the slot  1918  is provided on the applicator insert  1910 . 
     The applicator insert  1910  may provide and otherwise define an internal collimator  1920   a , which forms part of a hybrid sterilization assembly described in more detail below. The internal collimator  1920   a  may help define a portion of a sterilization zone  1922  and, more particularly, an upper portion  1924  of the sterilization zone  1922 . When the sensor control device  1802  is installed in the sensor applicator  102 , the distal ends of the sensor  1816  and the sharp  1818  may extend from the bottom of the electronics housing  1804  and reside within the upper portion  1924 . 
     In some embodiments, a microbial barrier  1926   a  may be positioned at an opening to the upper portion  1924  of the sterilization zone  1922 . The microbial barrier  1926   a  may help seal at least some of the upper portion  1924  of the sterilization zone  1922  to thereby isolate the distal ends of the sensor  1816  and the sharp  1818  from external contamination. The microbial barrier  1926   a  may be made of a radiation permeable material, such as a synthetic material (e.g., a flash-spun high-density polyethylene fiber). One example synthetic material comprises TYVEK®, available from DuPont®. In other embodiments, however, the microbial barrier  1926   a  may comprise, but is not limited to, tape, paper, film, foil, or any combination thereof. In at least one embodiment, the microbial barrier  1926   a  may comprise or otherwise be formed by a thinned portion of the applicator insert  1910 , without departing from the scope of the disclosure. 
     In some embodiments, a moisture barrier  1926   b  may be positioned or otherwise arranged at an opening  1928  to the applicator cap  1904 . Similar to the microbial barrier  1926   a , the moisture barrier  1926   b  may be configured to help isolate portions of the sensor applicator  102  from external contamination. The moisture barrier  1926   b  may be made of any of the materials mentioned above with reference to the microbial barrier  1926   a . In at least one embodiment, however, the moisture barrier  1926   b  may comprise a thinned portion of the applicator cap  1904 , without departing from the scope of the disclosure. In such embodiments, the opening  1928  would not be necessary. 
       FIGS.  20 A- 20 C  are various views of the applicator insert  1910 , according to one or more embodiments of the disclosure. More specifically,  FIG.  20 A  is an isometric top view,  FIG.  20 B  is an isometric bottom view, and  FIG.  20 C  is an isometric cross-sectional view of the applicator insert  1910 . As illustrated, the applicator insert  1910  includes a generally cylindrical body  2002  having a first or top end  2004   a  and a second or bottom end  2004   b  opposite the top end  2004   a . The top end  2004   a  is generally closed except for an aperture  2005  sized to receive the sensor  1816  ( FIG.  19 B ) and the sharp  1918  ( FIG.  19 B ) therethrough, and the bottom end  2004   b  is generally open. 
     The radial alignment feature  1916  described above is provided on a sidewall of the body  2002 . In some embodiments, additional radial alignment features  2006  (three shown) may be provided or otherwise defined on the sidewall of the body  2002 . In the illustrated embodiment, the additional radial alignment features  2006  each comprise a pair of longitudinally-extending tabs or projections  2008  angularly offset from each other on the sidewall to cooperatively define a slot  2010  therebetween. The slot  2010  may be size to receive a projection or tab provided on the sheath  1914  ( FIG.  19 B ) to help angularly (rotationally) orient the applicator insert  1910  relative to the sensor control device  1802  ( FIG.  19 B ). Moreover, similar to the arrangement of the radial alignment feature  1916 , the matable structures of the additional radial alignment features  2006  may alternatively be reversed, where the additional radial alignment features  2006  are instead provided on the sheath  1914  and the corresponding projection or tab is provided on the applicator insert  1910 . 
     As best seen in  FIGS.  20 A and  20 C , the applicator insert  1910  may further include one or more sensor locating features  2012  that may be used to also help properly orient the applicator insert  1910  relative to the sensor control device  1802  ( FIG.  19 B ) within the sensor applicator  102  ( FIG.  19 B ). As illustrated, the sensor locating features  2012  may be defined on and extend axially from the top end  2004   a  of the body  2002 . The sensor locating features  2012  may be sized to be received within corresponding apertures defined in the bottom of the sensor control device  1802 . In the illustrated embodiment, the sensor locating features  2012  comprise cylindrical projections, but could alternatively comprise other types of structural features suitable for mating with the corresponding features on the bottom of the sensor control device  1802 . The sensor locating features  2012 , in conjunction with the radial alignment feature  1916  and the additional radial alignment features  2006 , may prove especially advantageous in embodiments where the sensor control device  1802  comprises an eccentric orientation, where the sensor  1916  and the sharp  1918  are not concentric with the centerline of the sensor control device. 
     The internal collimator  1920   a  may be formed or otherwise provided at the top end  2004   a  of the applicator insert  1910 . As best seen in  FIG.  20 C , the internal collimator  1920   a  may be defined by the applicator insert  1910  and may include a collimating insert  2014  and a gasket  2016 . The internal collimator  1920   a  may be fabricated by first fabricating or otherwise producing the collimating insert  2014 . The applicator insert  1910  may then be overmolded onto the collimating insert  2014 . Also, the collimating insert  2014  could be insert molded into the applicator insert  1910 . Accordingly, the applicator insert  1910  may be made of a hard plastic. The gasket  2016  may then be molded onto the applicator insert  1910  in a second shot molding (overmolding) process. 
     The collimating insert  2014  may be made of a material that reduces or prevents sterilizing radiation from penetrating therethrough. Suitable materials for the collimating insert  2014  include, but are not limited to, a high-density polymer, (e.g., polyethylene, polypropylene, polystyrene, polytetrafluoroethylene, polyamide, etc.), a metal (e.g., lead, tungsten, stainless steel, aluminum, etc.), a composite material, or any combination thereof. In some embodiments, the collimating insert  2014  may be made of any material that has a mass density greater than 0.9 grams per cubic centimeter (g/cc). 
     The gasket  2016  may be made of any material that helps form a sealed interface with the bottom of the electronics housing  1804  ( FIG.  19 B ) when the applicator insert  1910  is installed in the sensor applicator  102  ( FIG.  19 B ). Suitable materials for the gasket  2016  include, but are not limited to, silicone, a thermoplastic elastomer (TPE), polytetrafluoroethylene (e.g., TEFLON®), or any combination thereof. As illustrated, the gasket  2016  may fill a void  2018  defined by the applicator insert  1910  and may provide an annular projection  2020  that protrudes past and/or from the upper surface of the top end  2004   a  of the body  2002 . The annular projection  2020  may prove advantageous in not only facilitating a sealed interface, but also in helping to take up tolerances as the applicator insert  1910  is installed in the sensor applicator  102 . Moreover, the mass of the gasket  2016  may also help absorb radiation during the sterilization processes described below, thus providing another layer of protection against radiation propagation. In at least one embodiment, the gasket  2016  may be large enough or of a material that absorbs sufficient radiation that the collimating insert  2014  may be omitted from the internal collimator  1920   a.    
       FIG.  21    is another cross-sectional side view of the sensor applicator  102  of  FIG.  19 A  showing a hybrid sterilization assembly  2102 , according to one or more embodiments of the disclosure. The hybrid sterilization assembly  2102 , alternately referred to as a “split collimation assembly” or “cooperative collimation assembly,” may be used to help sterilize the sensor control device  1802  and, more particularly, the distal ends of the sensor  1816  and the sharp  1818  extending from the bottom of the electronics housing  1804  while positioned within the sensor applicator  102 . More specifically, the fully assembled sensor control device  1802  may be subjected to radiation sterilization  2104  to sterilize the exposed portions of the sensor  1816  and the sharp  1818 . Suitable radiation sterilization  2104  processes include, but are not limited to, electron beam (e-beam) irradiation, gamma ray irradiation, X-ray irradiation, or any combination thereof. 
     The radiation sterilization  2104  may be delivered either through continuous processing irradiation or through pulsed beam irradiation. In pulsed beam irradiation, the beam of radiation sterilization  2104  is focused at a target location and the component part or device to be sterilized is moved to the target location at which point the irradiation is activated to provide a directed pulse of radiation. The radiation sterilization  2104  is then turned off, and another component part or device to be sterilized is moved to the target location and the process is repeated. 
     According to the present disclosure, the hybrid sterilization assembly  2102  may be used to help focus the radiation  2104  in sterilizing the distal ends of the sensor  1816  and the sharp  1818 , while simultaneously preventing (impeding) propagating radiation  2104  from damaging the radiation sensitive component  1908 . As illustrated, the hybrid sterilization assembly  2102  (hereafter the “assembly  2102 ”) may include the internal collimator  1920   a  previously described above and an external collimator  1920   b . As illustrated, the internal collimator  1920   a  may be arranged within the sensor applicator  102 , and the external collimator  1920   b  may extend into the sensor applicator  102  (i.e., the applicator cap  1904 ) by penetrating the opening  1928  to the applicator cap  1904 . The internal and external collimators  1920   a,b  may cooperatively define the sterilization zone  1922  that focuses the radiation  2104  (e.g., beams, waves, energy, etc.) to impinge upon and sterilize the sensor  1816  and the sharp  1818 . 
     In the illustrated embodiment, the external collimator  1920   b  is designed to align with the internal collimator  1920   a  and, more particularly, with the collimating insert  2014 . In at least one embodiment, for example, the collimating insert  2014 , may define a radial shoulder  2106  sized to receive and otherwise mate with an end of the external collimator  1920   b  extended into the applicator cap  1904 . The external collimator  1920   b  may transition to the internal collimator  1920   a  at the radial shoulder  2106 . In some embodiments, the transition between the internal and external collimators  1920   a,b  may be continuous, flush, or smooth. In other embodiments, however, the transition may be discontinuous or stepped, without departing from the scope of the disclosure. 
     Similar to the collimating insert  2014  of the internal collimator  1920   a , the external collimator  1920   b  may be made of a material that substantially prevents the radiation  2104  from penetrating the inner wall(s) of the sterilization zone  1922  and thereby damaging the radiation sensitive component  1908  within the electronics housing  1804 . Accordingly, the external collimator  1920   b  may be made of any of the materials mentioned herein as being suitable for the collimating insert  2014 . In at least one embodiment, the collimating insert  2014  and the external collimator  1920   b  may each be made of stainless steel. Moreover, however, as mentioned above the gasket  2016  may also provide a degree of shielding or protection against the radiation from damaging the radiation sensitive component  1908 . 
     The sterilization zone  1922  defined by the internal and external collimators  1920   a,b  can exhibit any suitable cross-sectional shape necessary to properly focus the radiation  2104  on the sensor  1816  and the sharp  1818  for sterilization. In the illustrated embodiment, for example, the external collimator  1920   b  is conical or frustoconical in shape, and the internal collimator  1920   a  exhibits a circular cross-sectional shape with parallel sides. In other embodiments, however, one or both of the internal and external collimators  1920   a,b  may exhibit a polygonal cross-sectional shape, such as cubic or rectangular (e.g., including parallelogram), without departing from the scope of the disclosure. 
     In the illustrated embodiment, the sterilization zone  1922  provides a first aperture  2108   a  defined by the external collimator  1920   b  and a second aperture  2108   b  defined by the internal collimator  1920   a , where the first and second apertures  2108   a,b  are located at opposing ends of the sterilization zone  1922 . The first aperture  2108   a  permits the radiation  2104  to enter the sterilization zone  1922 , and the second aperture  2108   b  provides a location where the sensor  1816  and the sharp  1818  may be received into the sterilization zone  1922 . 
     The diameter of the first aperture  2108   a  may be larger than the diameter of the second aperture  2108   b . For example, the size of the first aperture  2108   a  may range between about 5.0 mm and about 16.0 mm, and the size of the second aperture  2108   b  may range between about 0.5 mm and about 5.0 mm. The respective diameters of the first and second apertures  2108   a,b , however, may be greater or less than the ranges provided herein, without departing from the scope of the disclosure, and depending on the application. Indeed, the diameters of the first and second apertures  2108   a,b  need only be large enough to allow a sufficient dose of radiation to impinge upon the sensor  1816  and the sharp  1818 . In embodiments where the sterilization zone  1922  is substantially cylindrical and otherwise exhibit a circular or polygonal cross-section, the first and second apertures  2108   a,b  may exhibit identical diameters. In such embodiments, the walls of the sterilization zone  1922  may or may not be substantially parallel between the first and second ends of the sterilization zone  1922 . 
     The microbial barrier  1926   a  may be installed at the interface between the internal and external collimators  1920   a,b  and otherwise positioned at or near the radial shoulder  2106 . The microbial barrier  1926   a  may be present during the radiation sterilization process. As indicated above, the microbial barrier  1926   a  may help seal at least a portion of the sterilization zone  1922 . More particularly, the microbial barrier  1926   a  may seal off a portion of the sterilization zone  1922  to help form part of a sealed region  2110  configured to isolate the sensor  1816  and the sharp  1818  from external contamination. The sealed region  2110  may include (encompass) select portions of the interior of the electronics housing  1804  and the sterilization zone  1922 . In one or more embodiments, the sealed region  2110  may be defined and otherwise formed by at least the microbial barrier  1926   a , a first or “top” seal  2112   a , and a second or “bottom” seal  2112   b . The microbial barrier  1926   a  and the top and bottom seals  2112   a,b  may each create corresponding barriers at their respective sealing locations, thereby allowing the sterilization zone  1922  containing the sensor  1816  and the sharp  1818  to be terminally sterilized. 
     The top seal  2112   a  may be arranged to seal the interface between the sharp hub  1820  and the top of the electronics housing  1804  (i.e., the shell  1806  of  FIG.  18   ) and thereby prevent contaminants from migrating into the interior of the electronics housing  1804 . In some embodiments, the top seal  2112   a  may form part of the sharp hub  1820 , such as being overmolded onto the sharp hub  1820 . In other embodiments, however, the top seal  2112   a  may form part of or be overmolded onto the top surface of the shell  1806 . In yet other embodiments, the top seal  2112   a  may comprise a separate structure, such as an O-ring or the like, that interposes the sharp hub  1820  and the top surface of the shell  1806 , without departing from the scope of the disclosure. 
     The bottom seal  2112   b  may comprise the gasket  2016  ( FIG.  20 C ) and, more particularly, the annular projection  2020  ( FIGS.  20 A and  20 C ) overmolded onto the applicator insert  1910 . In operation, the bottom seal  2112   b  may be arranged to seal the interface between the applicator insert  1910  and the bottom of electronics housing  1804  (i.e., the mount  1808  of  FIG.  18   ). The bottom seal  2112   b  may prevent contaminants from migrating into the sterilization zone  1922  and from migrating into the interior of the electronics housing  1804 . 
     Upon loading the sensor control device  1802  into the sensor applicator  102  and securing the applicator cap  1904  to the sensor applicator  102 , the top and bottom seals  2112   a,b  may become progressively compressed and thereby generate corresponding sealed interfaces. The top and bottom seals  2112   a,b  may be made of a variety of materials capable of generating a sealed interface between opposing structures. Suitable materials include, but are not limited to, silicone, a thermoplastic elastomer (TPE), polytetrafluoroethylene (e.g., TEFLON®), or any combination thereof. 
     Once the radiation sterilization process is finished, the external collimator  1920   b  may be removed from the applicator cap  1904 , and the moisture barrier  1926   b  may be placed to occlude the opening  1928  in the applicator cap  1904 . Upon delivery, a user may simply remove the applicator cap  1904  in preparation for delivering the sensor control device  1802 . In at least one embodiment, removing the applicator cap  1904  will simultaneously remove the applicator insert  1910 , which may be received into the applicator cap  1904  in a manner that allows the applicator insert  1910  to be secured to the applicator cap  1904  for disassembly. In such embodiments, for example, the applicator insert  1910  may be coupled to the applicator cap  1904  using a snap fit engagement or the like. 
     In some embodiments, the electronics housing  1804  may be filled with a potting material  2114  that fills in voids within the sensor control device  1802 . The potting material  2114  may comprise a biocompatible material that meets the requirements of ISO 10993. In some embodiments, for example, the potting material  2114  may comprise a urethane material, such as Resinaid® 3672, or silicone materials, such as SI 5055 or SI 5240 available from Henkel®. In other embodiments, the potting material  2114  may comprise an acrylate adhesive material, such as GE4949 available from Delo®. 
     The potting material  2114  may also serve as an additional safety barrier for absorbing or deflecting propagating radiation  2104 . In at least one embodiment, for example, the potting material  2114  may exhibit an e-beam resistance of at least 85 kGy. Accordingly, instead of passing through air typically present within the electronics housing  1804 , the radiation  2104  may be required to pass through the potting material  2114  before impinging upon the radiation sensitive component(s)  1908 . Although the potting material  2114  may not comprise a high density material, it may nonetheless serve as another level of radiation shielding. Moreover, the potting material  2114  may also increase the robustness of the sensor control device  1802  and the electronics housing  1804 . Consequently, using the potting material  2114  may allow the electronics hosing  1804  to be made out of thinner materials, if desired. 
     It is noted that, while the sensor  1816  and the sharp  1818  extend from the bottom of the electronics housing  1804  and into the sterilization zone  1922  generally concentric with a centerline of the sensor applicator  102  and the applicator cap  1904 , it is contemplated herein to have an eccentric arrangement. More specifically, in at least one embodiment, the sensor  1816  and the sharp  1818  may extend from the bottom of the electronics housing  1804  eccentric to the centerline of the sensor applicator  102  and the applicator cap  1904 . In such embodiments, the internal and external collimators  1920   a,b  may be re-designed and otherwise configured such that the sterilization zone  1922  is also eccentrically positioned to receive the sensor  1816  and the sharp  1818 , without departing from the scope of the disclosure. 
       FIGS.  22 A and  22 B  are isometric and cross-sectional side views of another embodiment of the applicator insert  1910 . The applicator insert  1910  depicted in  FIGS.  22 A- 22 B  may be similar in most respects to the applicator insert  1910  of  FIGS.  20 A- 20 C . Unlike the applicator insert  1910  of  FIGS.  20 A- 20 C , however, the applicator insert  1910  of  FIGS.  22 A- 22 B  exhibits an eccentric orientation where the internal collimator  1920   a  is located eccentric to a centerline  2202  ( FIG.  22 B ) of the body  2002 . In such embodiments, the sensor control device  1802  ( FIGS.  19 B and  21   ) may also exhibit an eccentric orientation such that the sensor  1816  ( FIGS.  19 B and  21   ) and the sharp  1818  ( FIGS.  19 B and  21   ) are able to extend into the aperture  2005  defined in the top end  2004   a  of the applicator insert  1910 . Moreover, in such embodiments, the radial alignment feature  1916 , the additional radial alignment features  2006 , and the sensor locating features  2012  may prove particularly advantageous in helping to properly orient the applicator insert  1910  relative to the sensor control device  1802  within the sensor applicator  102  ( FIGS.  19 B and  21   ). 
     Embodiments disclosed herein include: 
     H. A sensor applicator that includes a housing having a sensor control device arranged therein, the sensor control device including a sensor, a sharp, and a radiation sensitive component, an applicator cap removably coupled to the housing, an applicator insert positionable within the applicator cap and defining an internal collimator that receives a distal end of the sensor and the sharp, and an external collimator extendable into the applicator cap, wherein the internal and external collimators cooperatively focus radiation from a radiation sterilization process toward the sensor and the sharp and simultaneously prevent the radiation from damaging the radiation sensitive component. 
     I. A method of sterilizing a sensor control device that includes positioning the sensor control device within a housing of a sensor applicator, the sensor control device including a sensor, a sharp, and a radiation sensitive component, receiving a distal end of the sensor and the sharp within an internal collimator defined by an applicator insert, removably coupling an applicator cap to the housing and thereby securing the applicator insert within the applicator cap, extending an external collimator into the applicator cap and aligning the external collimator with the internal collimator, and cooperatively focusing radiation from a radiation sterilization process toward the sensor and the sharp with the internal and external collimators while simultaneously preventing the radiation from damaging the radiation sensitive component. 
     J. A hybrid sterilization assembly that includes an applicator insert positionable within an applicator cap of a sensor applicator, an internal collimator defined by the applicator insert to receive a distal end of a sensor and a sharp of a sensor control device arranged within a housing of the sensor applicator, and an external collimator extendable into the applicator cap and alignable with the internal collimator, wherein the internal and external collimators cooperatively focus radiation from a radiation sterilization process toward the sensor and the sharp and simultaneously prevent the radiation from damaging the radiation sensitive component. 
     Each of embodiments H, I, and J may have one or more of the following additional elements in any combination: Element 1: wherein the applicator insert engages an inner surface of the applicator cap to axially secure the applicator insert within the applicator cap. Element 2: further comprising a sheath extending from the housing and into the applicator cap when the applicator cap is coupled to the housing, and one or more radial alignment features provided on the applicator insert and matable with one or more corresponding features provided on the sheath to rotationally orient the applicator insert relative to the sensor control device. Element 3: further comprising one or more sensor locating features provided on the applicator insert and matable with one or more corresponding features on the sensor control device to rotationally orient the applicator insert relative to the sensor control device. Element 4: wherein the internal collimator includes a collimating insert and the external collimator is alignable with the collimating insert. Element 5: wherein the collimating insert and the external collimator are each made of a material selected from the group consisting of a high-density polymer, a metal, a composite material, and any combination thereof. Element 6: wherein the internal collimator further includes a gasket engageable with a bottom of the sensor control device to generate a sealed interface. Element 7: wherein the external collimator comprises a cross-sectional shape selected from the group consisting of conical, frustoconical, pyramidal, circular, cubic, rectangular, and any combination thereof. Element 8: further comprising a potting material arranged within the sensor control device. 
     Element 9: further comprising engaging an inner surface of the applicator cap against the applicator insert and thereby axially securing the applicator insert within the applicator cap. Element 10: wherein the internal collimator includes a gasket, the method further comprising engaging the gasket against a bottom of the sensor control device as the applicator insert is axially secured within the applicator cap, and generating a sealed interface with the gasket against the bottom of the sensor control device. Element 11: wherein the internal and external collimators cooperatively define a sterilization zone that receives the sensor and the sharp, the method further comprising sealing at least a portion of the sterilization zone with a microbial barrier positioned at an interface between the internal and external collimators. Element 12: wherein the internal collimator includes a collimating insert and wherein aligning the external collimator with the internal collimator comprises aligning the external collimator with the collimating insert. Element 13: wherein the external collimator comprises a cross-sectional shape selected from the group consisting of conical, frustoconical, pyramidal, circular, cubic, rectangular, and any combination thereof. 
     Element 14: further comprising a microbial barrier positioned at an interface between the internal and external collimators. Element 15: wherein the internal collimator includes a collimating insert and wherein the collimating insert and the external collimator are each made of a material selected from the group consisting of a high-density polymer, a metal, a composite material, and any combination thereof. Element 16: wherein the internal collimator further includes a gasket engageable with a bottom of the sensor control device to generate a sealed interface. Element 17: wherein the external collimator comprises a cross-sectional shape selected from the group consisting of conical, frustoconical, pyramidal, circular, cubic, rectangular, and any combination thereof. 
     By way of non-limiting example, exemplary combinations applicable to H, I, and J include: Element 4 with Element 5; Element 4 with Element 6; Element 9 with Element 10; and Element 15 with Element 16. 
     Internal Sterilization Assemblies 
     Prior to being delivered to an end user, some medical devices must be sterilized to render the product free from viable microorganisms. Some medical devices, however, include under-skin sensing devices or sensors that must be sterilized using radiation sterilization, such as electron beam (“e-beam”) irradiation. Radiation sterilization, however, can damage electronic components associated with the medical device, which are commonly sterilized via gaseous chemical sterilization (e.g., using ethylene oxide). Gaseous chemical sterilization, however, can damage the enzymes or other chemistry and biologics included on the under-skin sensing devices. 
     In the past, this sterilization incompatibility has been circumvented by separating the under-skin sensing devices and the electronic components and sterilizing each individually. This approach, however, requires additional parts, packaging, process steps, and final assembly by the user, which introduces a possibility of user error. According to the present disclosure, any device requiring terminal sterilization, may be properly sterilized using an internal sterilization assembly designed to focus sterilizing radiation (e.g., beams, waves, energy, etc.) toward component parts requiring sterilization, while simultaneously preventing the propagating radiation from disrupting or damaging sensitive electronic components. 
       FIG.  23    is a schematic diagram of an example internal sterilization assembly  2300 , according to one or more embodiments of the present disclosure. The internal sterilization assembly  2300  (hereafter the “assembly  2300 ”) may be designed and otherwise configured to help sterilize a medical device  2302 . The medical device  2302  may comprise a type of a health care product including any device, mechanism, assembly, or system requiring terminal sterilization of one or more component parts. Suitable examples of the medical device  2302  include, but are not limited to, ingestible products, cardiac rhythm management (CRM) devices, under-skin sensing devices, externally mounted medical devices, medication delivery devices, or any combination thereof. 
     In the illustrated embodiment, the medical device  2302  comprises an under-skin sensing device or “sensor control device,” also referred to as an “in vivo analyte sensor control device”. As illustrated, the medical device  2302  may be housed within a sensor applicator  2304  (alternately referred to as an “inserter”) and a cap  2306  may be removably coupled to the sensor applicator  2304 . The medical device  2302  includes a housing  2308 , a part  2310  requiring sterilization, and one or more radiation sensitive components  2312 . In some embodiments, the part  2310  may comprise a sensor that extends from the housing  2308 . In at least one embodiment, the part  2310  may further include a sharp that may also require sterilization and may help implant the sensor beneath the skin of a user. As illustrated, the part  2310  may extend at an angle from the bottom of the housing  2308 , but could alternatively extend perpendicularly from the bottom or from another surface of the housing  2308 . Moreover, as illustrated, the part  2310  may extend from one end of the housing  2308  or otherwise offset from a centerline of the housing  2308 , but may alternatively extend concentric with the housing, without departing from the scope of the disclosure. 
     The sensor applicator  2304  is used to deliver the medical device  2302  to a target monitoring location on a user&#39;s skin (e.g., the arm of the user). In some embodiments, the cap  2306  may be threaded to the sensor applicator  2304  and removed from the sensor applicator  2304  by unscrewing the cap  2306  from engagement with the sensor applicator  2304 . Once the cap  2306  is removed, a user may then use the sensor applicator  2304  to position the medical device  2302  at a target monitoring location on the user&#39;s body. The part  2310  is positioned such that it can be transcutaneously positioned and otherwise retained under the surface of the user&#39;s skin. In some embodiments, the medical device  2302  may be spring loaded for ejection from the sensor applicator  2304 . Once delivered, the medical device  2302  may be maintained in position on the skin with an adhesive patch (not shown) coupled to the bottom of the medical device  2302 . 
     In the illustrated embodiment, the radiation sensitive component  2312  may be mounted to a printed circuit board (PCB)  2314  positioned within the housing  2308 . The radiation sensitive component  2312  may include one or more electronic modules such as, but not limited to, a data processing unit (e.g., an application specific integrated circuit or “ASIC”), a resistor, a transistor, a capacitor, an inductor, a diode, a switch, or any combination thereof. In other embodiments, however, the radiation sensitive component  2312  may comprise a radiation sensitive chemical solution or analyte (e.g., an active agent, pharmaceutical, biologic, etc.). In such embodiments, the medical device  2302  may alternatively comprise a hypodermic needle or syringe and the chemical solution or analyte may be positioned within an ampoule of the medical device  2302 . 
     The medical device  2302  may be subjected to radiation sterilization  2316  to properly sterilize the part  2310  for use. Suitable radiation sterilization  2316  processes include, but are not limited to, electron beam (e-beam) irradiation, gamma ray irradiation, X-ray irradiation, or any combination thereof. The cap  2306  may define a collimator  2318  that allows the radiation  2316  to impinge upon and sterilize the part  2310 . The cap  2306 , however, may also act as a radiation shield that helps prevent (impede) propagating radiation  2316  from disrupting or damaging the radiation sensitive component(s)  2312 . To accomplish this, the cap  2306  may be made of a material that reduces or prevents the radiation  2316  from penetrating therethrough. 
     More specifically, the cap  2306  may be made of a material having a density sufficient to absorb the dose of the radiation  2316  beam energy being delivered. In some embodiments, for example, the cap  2306  may be made of any material that has a mass density greater than 0.9 grams per cubic centimeter (g/cc). In other embodiments, however, the mass density of a suitable material may be less than 0.9 g/cc, without departing from the scope of the disclosure. Suitable materials for the cap  2306  include, but are not limited to, a high-density polymer, (e.g., polyethylene, polypropylene, polystyrene, polytetrafluoroethylene, etc.), a metal (e.g., lead, stainless steel, aluminum, etc.), any combination thereof, or any material having a mass density greater than 0.9 g/cc. 
     As illustrated, the collimator  2318  generally comprises a hole or passageway extending at least partially through the cap  2306 . The collimator  2318  defines a sterilization zone  2320  configured to focus the radiation  2316  toward the part  2310 . In the illustrated embodiment, the part  2310  may be received within the sterilization zone  2320  for sterilization. The collimator  2318  can exhibit any suitable cross-sectional shape necessary to focus the radiation  2316  on the part  2310  for sterilization. In the illustrated embodiment, for example, the collimator  2318  exhibits a circular cross-sectional shape with parallel sides. In other embodiments, however, the collimator  2318  may exhibit a polygonal cross-sectional shape, such as cubic or rectangular (e.g., including parallelogram), without departing from the scope of the disclosure. 
     In the illustrated embodiment, the collimator  2318  provides a first aperture  2322   a  and a second aperture  2322   b  where the first and second apertures  2322   a,b  are defined at opposing ends of the sterilization zone  2320 . The first aperture  2322   a  may allow the radiation  2316  to enter the sterilization zone  2320  and impinge upon the part  2310 , and the second aperture  2322   b  may be configured to receive the part  2310  into the sterilization zone  2320 . In embodiments where the collimator  2318  is cylindrical in shape, the first and second apertures  2322   a,b  exhibit identical diameters. 
     In some embodiments, a cap seal  2324  (shown in dashed lines) may be positioned at the opening of the collimator  2318  and otherwise at the first aperture  2322   a . The cap seal  2324  may comprise a radiation permeable, microbial barrier. In some embodiments, for example, the cap seal  2324  may be made of a synthetic material (e.g., a flash-spun high-density polyethylene fiber), such as TYVEK® available from DuPont®. In other embodiments, however, the cap seal  2324  may comprise, but it no limited to, tape, paper, foil, or any combination thereof. In yet other embodiments, the cap seal  2324  may comprise a thinned portion of the cap  2306 , without departing from the scope of the disclosure. In such embodiments, the first aperture  2322   a  would be omitted. 
     The cap seal  2324  may seal off a portion of the sterilization zone  2320  to isolate the part  2310  from external contamination, while simultaneously allowing the radiation  2316  to pass therethrough to sterilize the part  2310 . In some embodiments, a desiccant (not shown) may be arranged within the sterilization zone  2320 . 
     In some embodiments, the assembly  2300  may further include a barrier shield  2326  positioned within the housing  2308 . The barrier shield  2326  may be configured to help block radiation  2316  (e.g., electrons) from propagating within the housing  2308  toward the radiation sensitive component(s)  2312 . The barrier shield  2326  may be made of any of the materials mentioned above for the cap  2306 . In the illustrated embodiment, the barrier shield  2326  is positioned vertically within the housing  2308 , but may alternatively be positioned at any other angular configuration suitable for protecting the radiation sensitive component(s)  2312 . 
       FIG.  24    is a schematic diagram of another example internal sterilization assembly  2400 , according to one or more additional embodiments of the present disclosure. The internal sterilization assembly  2400  (hereafter the “assembly  2400 ”) may be similar in some respects to the assembly  2300  of  FIG.  23    and therefore may be best understood with reference thereto, where like numeral represent like components not described again in detail. Similar to the assembly  2300  of  FIG.  23   , for example, the assembly  2400  may be designed and otherwise configured to help sterilize a medical device  2402 , which may be similar to the medical device  2302  of  FIG.  23   . The medical device  2402  may comprise a sensor control device similar to the medical device  2302  of  FIG.  23   , but may alternatively comprise any of the health care products mentioned herein. 
     As illustrated, the medical device  2402  may be housed within a sensor applicator  2404  and, more specifically, within a pocket  2406  defined in the sensor applicator  2404 . In some embodiments, a desiccant (not shown) may be arranged within the pocket  2406 . Similar to the medical device  2302  of  FIG.  23   , the medical device  2402  may include the housing  2308 , the part  2310  requiring sterilization, and the radiation sensitive component(s)  2312 . In some embodiments, the assembly  2400  may further include the barrier shield  2326 , as generally described above. As illustrated, the part  2310  may extend perpendicularly from the bottom of the housing  2308 , but could alternatively extend at an angle or from another surface. Moreover, as illustrated, the part  2310  may extend along a centerline of the housing  2308 , but may alternatively extend eccentric to the centerline, without departing from the scope of the disclosure. 
     The sensor applicator  2404  is used to deliver the medical device  2402  to a target monitoring location on a user&#39;s skin (e.g., the arm of the user). As illustrated, the sensor applicator  2404  may include a spring-loaded button  2408  at least partially received within the sensor applicator  2404 . The button  2408  extends within a channel  2409  defined in the sensor applicator  2404  and is engageable with the top of the housing  2308  at its bottom end. In at least one embodiment, a sealed interface is created where the bottom of the button  2406  engages the housing  2308 . The medical device  2402  may be deployed for use from the pocket  2406  by pressing down on the button  2408 , which acts on the housing  2308  and thereby pushes the medical device  2402  distally and out of the pocket  2406  and away from the sensor applicator  2404 . The part  2310  is positioned such that it can be transcutaneously positioned and otherwise retained under the surface of the user&#39;s skin. Once delivered, the medical device  2402  may be maintained in position on the skin with an adhesive patch (not shown) coupled to the bottom of the medical device  2402 . 
     The medical device  2402  may be subjected to radiation sterilization  2316  to properly sterilize the part  2310  prior to use. In the illustrated embodiment, the radiation sterilization  2316  is directed to the top of the sensor applicator  2404  and the button  2408  defines a collimator  2410  that allows the radiation  2316  to impinge upon and sterilize the part  2310 . As illustrated, the collimator  2410  generally comprises a hole or passageway extending at least partially through the button  2408 . The collimator  2410  focuses the radiation  2316  toward the part  2310  and can exhibit any suitable cross-sectional shape necessary to focus the radiation  2316  on the part  2310  for sterilization. In the illustrated embodiment, for example, the collimator  2410  exhibits a circular cross-section with parallel sides. In other embodiments, however, the collimator  2410  may exhibit a polygonal cross-sectional shape, such as cubic or rectangular (e.g., including parallelogram), without departing from the scope of the disclosure. 
     Portions of the sensor applicator  2404  and the button  2408 , however, may also act as a radiation shield that helps prevent (impede) propagating radiation  2316  from disrupting or damaging the radiation sensitive component(s)  2312 , except through the collimator  2410 . To accomplish this, the sensor applicator  2404  and the button  2408  may be made of a material similar to the material of the cap  2306  of  FIG.  23   . In at least one embodiment, the radiation sterilization  2316  may be emitted from a device or machine configured to focus and/or aim the radiation  2316  directly into the collimator  2410 , and thereby mitigating radiation  2316  exposure to adjacent portions of the sensor applicator  2404 . 
     In some embodiments, a first seal  2412   a  (shown in dashed lines) may be positioned at the opening of the pocket  2406 , and a second seal  2412   b  may be arranged at the opening to the collimator  2410  at the top of the button  2406 . The seals  2412   a,b  may comprise radiation permeable, microbial barriers, similar to the cap seal  2324  of  FIG.  23   . The first seal  2412   a  may seal off the pocket  2406  on the bottom of the sensor applicator  2404  to isolate the part  2310  from external contamination, and the second seal  2412   b  may seal off the collimator  2410 , while simultaneously allowing the radiation  2316  to pass therethrough to sterilize the part  2310 . 
       FIG.  25    is a schematic diagram of another example internal sterilization assembly  2500 , according to one or more additional embodiments of the present disclosure. The internal sterilization assembly  2500  (hereafter the “assembly  2500 ”) may be similar in some respects to the assemblies  2300  and  2400  of  FIGS.  23  and  24    and therefore may be best understood with reference thereto, where like numeral represent like components not described again in detail. Similar to the assemblies  2300  and  2400  of  FIGS.  23  and  24   , for example, the assembly  2500  may be designed and otherwise configured to help sterilize a medical device  2502 , which may be similar to the medical devices  2302  and  2402  of  FIGS.  23  and  24   . The medical device  2502  may comprise a sensor control device similar to the medical devices  2302  and  2402  of  FIGS.  23  and  24   , but may alternatively comprise any of the health care products mentioned herein. 
     As illustrated, the medical device  2502  may be housed within a sensor applicator  2504 , which may include a spring-loaded sheath  2506 . The medical device  2502  may be positioned within a pocket  2508  defined at least partially by the sheath  2506 . In some embodiments, a desiccant (not shown) may be arranged within the pocket  2508 . Similar to the medical devices  2302  and  2402  of  FIGS.  23  and  24   , the medical device  2502  may include the housing  2308 , the part  2310  requiring sterilization, and the radiation sensitive component(s)  2312 . In some embodiments, the assembly  2500  may further include the barrier shield  2326 , as generally described above. 
     As illustrated, the part  2310  may extend perpendicularly from the bottom of the housing  2308 , but could alternatively extend at an angle or from another surface. Moreover, as illustrated, the part  2310  may extend along a centerline of the housing  2308 , but may alternatively extend eccentric to the centerline, without departing from the scope of the disclosure. 
     The sensor applicator  2504  is used to deliver the medical device  2502  to a target monitoring location on a user&#39;s skin (e.g., the arm of the user). The medical device  2502  may be deployed for use from the pocket  2508  by forcing the sheath  2506  against the user&#39;s skin and thereby causing the sheath  2506  to collapse into the body of the sensor applicator  2504 . Once the sheath  2506  collapses past the housing  2308 , the medical device  2502  may be discharged from the sensor applicator  2504 . The part  2310  is positioned such that it can be transcutaneously positioned and otherwise retained under the surface of the user&#39;s skin. Once delivered, the medical device  2502  may be maintained in position on the skin with an adhesive patch (not shown) coupled to the bottom of the medical device  2502 . 
     The medical device  2502  may be subjected to radiation sterilization  2316  to properly sterilize the part  2310  prior to use. In the illustrated embodiment, the radiation sterilization  2316  is directed to the top of the sensor applicator  2504 , which defines a collimator  2510  that allows the radiation  2316  to impinge upon and sterilize the part  2310 . As illustrated, the collimator  2510  generally comprises a hole or passageway extending through the body of the sensor applicator  2504 . The collimator  2510  focuses the radiation  2316  toward the part  2310  and can exhibit any suitable cross-sectional shape necessary to focus the radiation  2316  on the part  2310  for sterilization. In the illustrated embodiment, for example, the collimator  2510  exhibits a circular cross-sectional shape with parallel sides. In other embodiments, however, the collimator  2510  may exhibit a polygonal cross-sectional shape, such as cubic or rectangular (e.g., including parallelogram), without departing from the scope of the disclosure. 
     The sensor applicator  2504 , however, may also act as a radiation shield that helps prevent (impede) propagating radiation  2316  from disrupting or damaging the radiation sensitive component(s)  2312 , except through the collimator  2510 . To accomplish this, the sensor applicator  2504  may be made of a material similar to the material of the cap  2306  of  FIG.  23   . In at least one embodiment, however, the radiation sterilization  2316  may be emitted from a device or machine configured to focus and/or aim the radiation  2316  directly into the collimator  2510 , and thereby mitigating radiation  2316  exposure to adjacent portions of the sensor applicator  2504 . 
     In some embodiments, a first seal  2512   a  (shown in dashed lines) may be positioned at the opening of the pocket  2508 , and a second seal  2512   b  may be arranged at the opening to the collimator  2510  at the top of the sensor applicator  2504 . The seals  2512   a,b  may comprise radiation permeable, microbial barriers, similar to the cap seal  2324  of  FIG.  23   . The first seal  2512   a  may seal off the pocket  2508  on the bottom of the sensor applicator  2504  to isolate the part  2310  from external contamination, and the second seal  2512   b  may seal off the collimator  2510 , while simultaneously allowing the radiation  2316  to pass therethrough to sterilize the part  2310 . 
     Embodiments disclosed herein include: 
     K. An internal sterilization assembly that includes a sensor applicator, a medical device at least partially housed within the sensor applicator and having a part requiring sterilization and a radiation sensitive component, and a cap removably coupled to the sensor applicator and providing a collimator alignable with the part requiring sterilization, wherein the collimator focuses radiation from a radiation sterilization process toward the part requiring sterilization and the radiation is prevented from damaging the radiation sensitive component. 
     Embodiment K may have one or more of the following additional elements in any combination: Element 1: wherein the radiation sensitive component is selected from the group consisting of an electronic module, a chemical solution, and any combination thereof. Element 2: wherein the collimator comprises a cross-sectional shape selected from the group consisting of circular, cubic, rectangular, and any combination thereof. Element 3: wherein the medical device comprises an in vivo analyte sensor control device and the part requiring sterilization comprises at least one of a sensor and a sharp extending from the housing of the in vivo analyte sensor control device. Element 4: wherein the at least one of the sensor and the sharp extends at an angle from the bottom of the housing. Element 5: wherein the at least one of the sensor and the sharp extends perpendicularly from the bottom of the housing. Element 6: wherein the at least one of the sensor and the sharp extends from the bottom of the housing along a centerline of the housing. Element 7: wherein the at least one of the sensor and the sharp extends from the bottom of the housing offset from a centerline of the housing. Element 8: wherein the cap is made of a material having a mass density greater than 0.9 g/cc. Element 9: wherein the cap is made of a material selected from the group consisting of a high-density polymer, a metal, and any combination thereof. Element 10: wherein the medical device comprises an in vivo analyte sensor control device having a housing that houses the radiation sensitive component, the internal sterilization assembly further comprising a barrier shield positioned within the housing to block the radiation from propagating within the housing toward the radiation sensitive component. Element 11: further comprising a spring-loaded button at least partially received within the sensor applicator and engageable with a top of the medical device, wherein the collimator is defined through the button. Element 12: further comprising a sealed interface at the intersection of the button and the medical device. Element 13: wherein at least one of the button and the sensor applicator is made of a material selected from the group consisting of a high-density polymer, a metal, and any combination thereof. Element 14: wherein the sensor applicator includes a spring-loaded sheath and the medical device is housed within a pocket at least partially defined by the sheath. Element 15: wherein the collimator is defined through the sensor applicator. 
     By way of non-limiting example, exemplary combinations applicable to A, B, and C include: Element 3 with Element 4; Element 3 with Element 5; Element 3 with Element 6; Element 3 with Element 7; Element 8 with Element 9; Element 11 with Element 12; Element 11 with Element 13; and Element 14 with Element 15. 
     One-Piece Bio-Sensor Design with Sensor Preservation Vial 
       FIGS.  26 A and  26 B  are isometric and side views, respectively, of an example sensor control device  2602 , according to one or more embodiments of the present disclosure. The sensor control device  2602  (alternately referred to as a “puck”) may be similar in some respects to the sensor control device  104  of  FIG.  1    and therefore may be best understood with reference thereto. The sensor control device  2602  may replace the sensor control device  104  of  FIG.  1    and, therefore, may be used in conjunction with the sensor applicator  102  ( FIG.  1   ), which delivers the sensor control device  2602  to a target monitoring location on a user&#39;s skin. 
     The sensor control device  2602 , however, may be incorporated into a one-piece system architecture in contrast to the sensor control device  104  of  FIG.  1   . Unlike the two-piece architecture, for example, a user is not required to open multiple packages and finally assemble the sensor control device  2602 . Rather, upon receipt by the user, the sensor control device  2602  is already fully assembled and properly positioned within the sensor applicator  102  ( FIG.  1   ). To use the sensor control device  2602 , the user need only open one barrier (e.g., the applicator cap  210  of  FIG.  2 B ) before promptly delivering the sensor control device  2602  to the target monitoring location. 
     As illustrated, the sensor control device  2602  includes an electronics housing  2604  that is generally disc-shaped and may have a circular cross-section. In other embodiments, however, the electronics housing  2604  may exhibit other cross-sectional shapes, such as ovoid or polygonal, without departing from the scope of the disclosure. The electronics housing  2604  may be configured to house or otherwise contain various electrical components used to operate the sensor control device  2602 . 
     The electronics housing  2604  may include a shell  2606  and a mount  2608  that is matable with the shell  2606 . The shell  2606  may be secured to the mount  2608  via a variety of ways, such as a snap fit engagement, an interference fit, sonic welding, or one or more mechanical fasteners (e.g., screws). In some cases, the shell  2606  may be secured to the mount  2608  such that a sealed interface therebetween is generated. In such embodiments, a gasket or other type of seal material may be positioned at or near the outer diameter (periphery) of the shell  2606  and the mount  2608 , and securing the two components together may compress the gasket and thereby generate a sealed interface. In other embodiments, an adhesive may be applied to the outer diameter (periphery) of one or both of the shell  2606  and the mount  2608 . The adhesive secures the shell  2606  to the mount  2608  and provides structural integrity, but may also seal the interface between the two components and thereby isolate the interior of the electronics housing  2604  from outside contamination. If the sensor control device  2602  is assembled in a controlled environment, there may be no need to terminally sterilize the internal electrical components. Rather, the adhesive coupling may provide a sufficient sterile barrier for the assembled electronics housing  2604 . 
     The sensor control device  2602  may further include a plug assembly  2610  that may be coupled to the electronics housing  2604 . The plug assembly  2610  may be similar in some respects to the plug assembly  207  of  FIG.  2 A . For example, the plug assembly  2610  may include a sensor module  2612  (partially visible) interconnectable with a sharp module  2614  (partially visible). The sensor module  2612  may be configured to carry and otherwise include a sensor  2616  (partially visible), and the sharp module  2614  may be configured to carry and otherwise include a sharp  2618  (partially visible) used to help deliver the sensor  2616  transcutaneously under a user&#39;s skin during application of the sensor control device  2602 . As illustrated, corresponding portions of the sensor  2616  and the sharp  2618  extend from the electronics housing  2604  and, more particularly, from the bottom of the mount  2608 . The exposed portion of the sensor  2616  may be received within a hollow or recessed portion of the sharp  2618 . The remaining portion of the sensor  2616  is positioned within the interior of the electronics housing  2604 . 
     As discussed in more detail below, the sensor control device  2602  may further include a sensor preservation vial  2620  that provides a preservation barrier surrounding and protecting the exposed portions of the sensor  2616  and the sharp  2618  from gaseous chemical sterilization. 
       FIGS.  27 A and  27 B  are isometric and exploded views, respectively, of the plug assembly  2610 , according to one or more embodiments. The sensor module  2612  may include the sensor  2616 , a plug  2702 , and a connector  2704 . The plug  2702  may be designed to receive and support both the sensor  2616  and the connector  2704 . As illustrated, a channel  2706  may be defined through the plug  2702  to receive a portion of the sensor  2616 . Moreover, the plug  2702  may provide one or more deflectable arms  2707  configured to snap into corresponding features provided on the bottom of the electronics housing  2604  ( FIGS.  26 A- 26 B ). 
     The sensor  2616  includes a tail  2708 , a flag  2710 , and a neck  2712  that interconnects the tail  2708  and the flag  2710 . The tail  2708  may be configured to extend at least partially through the channel  2706  and extend distally from the plug  2702 . The tail  2708  includes an enzyme or other chemistry or biologic and, in some embodiments, a membrane may cover the chemistry. In use, the tail  2708  is transcutaneously received beneath a user&#39;s skin, and the chemistry included thereon helps facilitate analyte monitoring in the presence of bodily fluids. 
     The flag  2710  may comprise a generally planar surface having one or more sensor contacts  2714  (three shown in  FIG.  27 B ) arranged thereon. The sensor contact(s)  2714  may be configured to align with a corresponding number of compliant carbon impregnated polymer modules (tops of which shown at  2720 ) encapsulated within the connector  2704 . 
     The connector  2704  includes one or more hinges  2718  that enables the connector  2704  to move between open and closed states. The connector  2704  is depicted in  FIGS.  27 A- 27 B  in the closed state, but can pivot to the open state to receive the flag  2710  and the compliant carbon impregnated polymer module(s) therein. The compliant carbon impregnated polymer module(s) provide electrical contacts  2720  (three shown) configured to provide conductive communication between the sensor  2616  and corresponding circuitry contacts provided within the electrical housing  2604  ( FIGS.  26 A- 26 B ). The connector  2704  can be made of silicone rubber and may serve as a moisture barrier for the sensor  2616  when assembled in a compressed state and after application to a user&#39;s skin. 
     The sharp module  2614  includes the sharp  2618  and a sharp hub  2722  that carries the sharp  2618 . The sharp  2618  includes an elongate shaft  2724  and a sharp tip  2726  at the distal end of the shaft  2724 . The shaft  2724  may be configured to extend through the channel  2706  and extend distally from the plug  2702 . Moreover, the shaft  2724  may include a hollow or recessed portion  2728  that at least partially circumscribes the tail  2708  of the sensor  2616 . The sharp tip  2726  may be configured to penetrate the skin while carrying the tail  2708  to put the active chemistry present on the tail  2708  into contact with bodily fluids. 
     The sharp hub  2722  may include a hub small cylinder  2730  and a hub snap pawl  2732 , each of which may be configured to help couple the plug assembly  2610  (and the entire sensor control device  2602 ) to the sensor applicator  102  ( FIG.  1   ). 
     With specific reference to  FIG.  27 B , the preservation vial  2620  may comprise a generally cylindrical and elongate body  2734  having a first end  2736   a  and a second end  2736   b  opposite the first end  2736   a . The first end  2736   a  may be open to provide access into an inner chamber  2738  defined within the body  2734 . In contrast, the second end  2736   b  may be closed and may provide or otherwise define an enlarged head  2740 . The enlarged head  2740  exhibits an outer diameter that is greater than the outer diameter of the remaining portions of the body  2734 . In other embodiments, however, the enlarged head  2740  may be positioned at an intermediate location between the first and second ends  2736   a,b.    
       FIG.  27 C  is an exploded isometric bottom view of the plug  2702  and the preservation vial  2620 . As illustrated, the plug  2702  may define an aperture  2742  configured to receive the preservation vial  2620  and, more particularly, the first end  2736   a  of the body  2734 . The channel  2706  may terminate at the aperture  2742  such that components extending out of and distally from the channel  2706  will be received into the inner chamber  2738  when the preservation vial  2620  is coupled to the plug  2702 . 
     The preservation vial  2620  may be removably coupled to the plug  2702  at the aperture  2742 . In some embodiments, for example, the preservation vial  2620  may be received into the aperture  2742  via an interference or friction fit. In other embodiments, the preservation vial  2620  may be secured within the aperture  2742  with a frangible member (e.g., a shear ring) or substance that may be broken with minimal separation force. In such embodiments, for example, the preservation vial  2620  may be secured within the aperture  2742  with a tag (spot) of glue, a dab of wax, or the preservation vial  2620  may include an easily peeled off glue. As described below, the preservation vial  2620  may be separated from the plug  2702  prior to delivering the sensor control device  2602  ( FIGS.  26 A- 26 B ) to the target monitoring location on the user&#39;s skin. 
     Referring again to  FIGS.  27 A and  27 B , the inner chamber  2738  may be sized and otherwise configured to receive the tail  2708 , a distal section of the shaft  2724 , and the sharp tip  2726 , collectively referred to as the “distal portions of the sensor  2616  and the sharp  2618 .” The inner chamber  2738  may be sealed or otherwise isolated to prevent substances that might adversely interact with the chemistry of the sensor  2616  from migrating into the inner chamber  2738 . More specifically, the inner chamber  2728  may be sealed to protect or isolate the distal portions of the sensor  2616  and the sharp  2618  during a gaseous chemical sterilization process since gases used during gaseous chemical sterilization can adversely affect the enzymes (and other sensor components, such as membrane coatings that regulate analyte influx) provided on the tail  2708 . 
     In some embodiments, a seal  2744  ( FIG.  27 B ) may provide a sealed barrier between the inner chamber  2738  and the exterior environment. In at least one embodiment, the seal  2744  may be arranged within the inner chamber  2738 , but could alternatively be positioned external to the body  2734 , without departing from the scope of the disclosure. The distal portions of the sensor  2616  and the sharp  2618  may penetrate the seal  2744  and extend into the inner chamber  2738 , but the seal  2744  may maintain a sealed interface about the distal portions of the sensor  2616  and the sharp  2618  to prevent migration of contaminants into the inner chamber  2738 . The seal  2744  may be made of, for example, a pliable elastomer or a wax. 
     In other embodiments (or in addition to the seal  2744 ), a sensor preservation fluid  2746  ( FIG.  27 B ) may be present within the inner chamber  2738  and the distal portions of the sensor  2616  and the sharp  2618  may be immersed in or otherwise encapsulated by the preservation fluid  2746 . The preservation fluid  2746  may generate a sealed interface that prevents sterilization gases from interacting with the enzymes provided on the tail  2708 . 
     The plug assembly  2610  may be subjected to radiation sterilization to properly sterilize the sensor  2616  and the sharp  2618 . Suitable radiation sterilization processes include, but are not limited to, electron beam (e-beam) irradiation, gamma ray irradiation, X-ray irradiation, or any combination thereof. In some embodiments, the plug assembly  2610  may be subjected to radiation sterilization prior to coupling the preservation vial  2620  to the plug  2702 . In other embodiments, however, the plug assembly  2610  may sterilized after coupling the preservation vial  2620  to the plug  2702 . In such embodiments, the body  2734  of the preservation vial  2620  and the preservation fluid  2746  may comprise materials and/or substances that permit the propagation of radiation therethrough to facilitate radiation sterilization of the distal portions of the sensor  2616  and the sharp  2618 . 
     Suitable materials for the body  2734  include, but are not limited to, a non-magnetic metal (e.g., aluminum, copper, gold, silver, etc.), a thermoplastic, ceramic, rubber (e.g., ebonite), a composite material (e.g., fiberglass, carbon fiber reinforced polymer, etc.), an epoxy, or any combination thereof. In some embodiments, the material for the body  2734  may be transparent or translucent, but can otherwise be opaque, without departing from the scope of the disclosure. 
     The preservation fluid  2746  may comprise any inert and biocompatible fluid (i.e., liquid, gas, gel, wax, or any combination thereof) capable of encapsulating the distal portions of the sensor  2616  and the sharp  2618 . In some embodiments, the preservation fluid  2746  may also permit the propagation of radiation therethrough. The preservation fluid  2746  may comprise a fluid that is insoluble with the chemicals involved in gaseous chemical sterilization. Suitable examples of the preservation fluid  2746  include, but are not limited to, silicone oil, mineral oil, a gel (e.g., petroleum jelly), a wax, fresh water, salt water, a synthetic fluid, glycerol, sorbitan esters, or any combination thereof. As will be appreciated, gels and fluids that are more viscous may be preferred so that the preservation fluid  2746  does not flow easily. 
     In some embodiments, the preservation fluid  2746  may include an anti-inflammatory agent, such as nitric oxide or another known anti-inflammatory agent. The anti-inflammatory agent may prove advantageous in minimizing local inflammatory response caused by penetration of the sharp  2618  and the sensor  2616  into the skin of the user. It has been observed that inflammation can affect the accuracy of glucose readings, and by including the anti-inflammatory agent the healing process may be accelerated, which may result in obtaining accurate readings more quickly. 
       FIGS.  28 A and  28 B  are exploded and bottom isometric views, respectively, of the electronics housing  2604 , according to one or more embodiments. The shell  2606  and the mount  2608  operate as opposing clamshell halves that enclose or otherwise substantially encapsulate the various electronic components of the sensor control device  2602  ( FIGS.  26 A- 26 B ). 
     A printed circuit board (PCB)  2802  may be positioned within the electronics housing  2604 . A plurality of electronic modules (not shown) may be mounted to the PCB  2802  including, but not limited to, a data processing unit, resistors, transistors, capacitors, inductors, diodes, and switches. The data processing unit may comprise, for example, an application specific integrated circuit (ASIC) configured to implement one or more functions or routines associated with operation of the sensor control device  2602 . More specifically, the data processing unit may be configured to perform data processing functions, where such functions may include but are not limited to, filtering and encoding of data signals, each of which corresponds to a sampled analyte level of the user. The data processing unit may also include or otherwise communicate with an antenna for communicating with the reader device  106  ( FIG.  1   ). 
     As illustrated, the shell  2606 , the mount  2608 , and the PCB  2802  each define corresponding central apertures  2804 ,  2806 , and  2808 , respectively. When the electronics housing  2604  is assembled, the central apertures  2804 ,  2806 ,  2808  coaxially align to receive the plug assembly  2610  ( FIGS.  27 A- 27 B ) therethrough. A battery  2810  may also be housed within the electronics housing  2604  and configured to power the sensor control device  2602 . 
     In  FIG.  28 B , a plug receptacle  2812  may be defined in the bottom of the mount  2808  and provide a location where the plug assembly  2610  ( FIGS.  27 A- 27 B ) may be received and coupled to the electronics housing  2604 , and thereby fully assemble the sensor control device  2602  ( FIG.  26 A- 3 B ). The profile of the plug  2702  ( FIGS.  27 A- 27 C ) may match or be shaped in complementary fashion to the plug receptacle  2812 , and the plug receptacle  2812  may provide one or more snap ledges  2814  (two shown) configured to interface with and receive the deflectable arms  2707  ( FIGS.  27 A- 27 B ) of the plug  2702 . The plug assembly  2610  is coupled to the electronics housing  2604  by advancing the plug  2702  into the plug receptacle  2812  and allowing the deflectable arms  2707  to lock into the corresponding snap ledges  2814 . When the plug assembly  2610  ( FIGS.  27 A- 27 B ) is properly coupled to the electronics housing  2604 , one or more circuitry contacts  2816  (three shown) defined on the underside of the PCB  2802  may make conductive communication with the electrical contacts  2720  ( FIGS.  27 A- 27 B ) of the connector  2704  ( FIGS.  27 A- 27 B ). 
       FIGS.  29 A and  29 B  are side and cross-sectional side views, respectively, of an example embodiment of the sensor applicator  102  with the applicator cap  210  coupled thereto. More specifically,  FIGS.  29 A- 29 B  depict how the sensor applicator  102  might be shipped to and received by a user. According to the present disclosure, and as seen in  FIG.  29 B , the sensor control device  2602  is already assembled and installed within the sensor applicator  102  prior to being delivered to the user. 
     As indicated above, prior to coupling the plug assembly  2610  to the electronics housing  2604 , the plug assembly  2610  may be subjected to radiation sterilization to sterilize the distal portions of the sensor  2616  and the sharp  2618 . Once properly sterilized, the plug assembly  2610  may then be coupled to the electronics housing  2604 , as generally described above, and thereby form the fully assembled sensor control device  2602 . The sensor control device  2602  may then be loaded into the sensor applicator  102 , and the applicator cap  210  may be coupled to the sensor applicator  102 . The applicator cap  210  may be threaded to the housing  208  and include a tamper ring  2902 . Upon rotating (e.g., unscrewing) the applicator cap  210  relative to the housing  208 , the tamper ring  2902  may shear and thereby free the applicator cap  210  from the sensor applicator  102 . 
     According to the present disclosure, while loaded in the sensor applicator  102 , the sensor control device  2602  may be subjected to gaseous chemical sterilization  2904  configured to sterilize the electronics housing  2604  and any other exposed portions of the sensor control device  2602 . To accomplish this, a chemical may be injected into a sterilization chamber  2906  cooperatively defined by the sensor applicator  102  and the interconnected cap  210 . In some applications, the chemical may be injected into the sterilization chamber  2906  via one or more vents  2908  defined in the applicator cap  210  at its proximal end  2910 . Example chemicals that may be used for the gaseous chemical sterilization  2904  include, but are not limited to, ethylene oxide, vaporized hydrogen peroxide, and nitrogen oxide (e.g., nitrous oxide, nitrogen dioxide, etc.). 
     Since the distal portions of the sensor  2616  and the sharp  2618  are sealed within the preservation vial  2620 , the chemicals used during the gaseous chemical sterilization process do not interact with the enzymes, chemistry or biologics provided on the tail  2708 . 
     Once a desired sterility assurance level has been achieved within the sterilization chamber  2906 , the gaseous solution is removed and the sterilization chamber  2906  is aerated. Aeration may be achieved by a series of vacuums and subsequently circulating nitrogen gas or filtered air through the sterilization chamber  2906 . Once the sterilization chamber  2906  is properly aerated, the vents  2908  may be occluded with a seal  2912  (shown in dashed lines). 
     In some embodiments, the seal  2912  may comprise two or more layers of different materials. The first layer may be made of a synthetic material (e.g., a flash-spun high-density polyethylene fiber), such as Tyvek® available from DuPont®. Tyvek® is highly durable and puncture resistant and allows the permeation of vapors. The Tyvek® layer can be applied before the gaseous chemical sterilization process, and following the gaseous chemical sterilization process, a foil or other vapor and moisture resistant material layer may be sealed (e.g., heat sealed) over the Tyvek® layer to prevent the ingress of contaminants and moisture into the sterilization chamber  2906 . In other embodiments, the seal  2912  may comprise only a single protective layer applied to the applicator cap  210 . In such embodiments, the single layer is gas permeable for the sterilization process, but is also capable of protection against moisture and other harmful elements once the sterilization process is complete. 
     With the seal  2912  in place, the applicator cap  210  provides a barrier against outside contamination, and thereby maintains a sterile environment for the assembled sensor control device  2602  until the user removes (unthreads) the applicator cap  210 . The applicator cap  210  may also create a dust-free environment during shipping and storage that prevents an adhesive patch  2914  used to secure the sensor control device  2602  to the user&#39;s skin from becoming dirty. 
       FIG.  30    is a perspective view of an example embodiment of the applicator cap  210 , according to the present disclosure. As illustrated, the applicator cap  210  has a generally circular cross-section and defines a series of threads  7302  used to couple the applicator cap  210  to the sensor applicator  102  ( FIGS.  29 A and  29 B ). The vents  2908  are also visible in the bottom of the applicator cap  210 . 
     The applicator cap  210  may further provide and otherwise define a cap post  3004  centrally located within the interior of the applicator cap  210  and extending proximally from the bottom thereof. The cap post  3004  may be configured to help support the sensor control device  2602  while contained within the sensor applicator  102  ( FIGS.  29 A- 29 B ). Moreover, the cap post  3004  may define an opening  3006  configured to receive the preservation vial  2620  as the applicator cap  210  is coupled to the sensor applicator  102 . 
     In some embodiments, the opening  3006  to the cap post  3004  may include one or more compliant features  3008  that are expandable or flexible to enable the preservation vial  2620  to pass therethrough. In some embodiments, for example, the compliant feature(s)  3008  may comprise a collet-type device that includes a plurality of compliant fingers configured to flex radially outward to receive the preservation vial  2620 . In other embodiments, however, the compliant feature(s)  3008  may comprise an elastomer or another type of compliant material configured to expand radially to receive the preservation vial  2620 . 
       FIG.  31    is a cross-sectional side view of the sensor control device  2602  positioned within the applicator cap  210 , according to one or more embodiments. As illustrated, the cap post  3004  defines a post chamber  3102  configured to receive the preservation vial  2620 . The opening  3006  to the cap post  3004  provides access into the post chamber  3102  and exhibits a first diameter D 1 . In contrast, the enlarged head  2740  of the preservation vial  2620  exhibits a second diameter D 2  that is larger than the first diameter D 1  and greater than the outer diameter of the remaining portions of the preservation vial  2620 . Accordingly, as the preservation vial  2620  is extended into the post chamber  3102 , the compliant feature(s)  3008  of the opening  3006  may flex (expand) radially outward to receive the enlarged head  2740 . 
     In some embodiments, the enlarged head  2740  may provide or otherwise define an angled outer surface that helps bias the compliant feature(s)  3008  radially outward. The enlarged head  2740 , however, may also define an upper shoulder  3104  that prevents the preservation vial  2620  from reversing out of the post chamber  3102 . More specifically, the shoulder  3104  may comprise a sharp surface at the second diameter D 2  that will engage but not urge the compliant feature(s)  3008  to flex radially outward in the reverse direction. 
     Once the enlarged head  2740  bypasses the opening  3006 , the compliant feature(s)  3008  flex back to (or towards) their natural state. In some embodiments, the compliant feature(s)  3008  may engage the outer surface of the preservation vial  2620 , but may nonetheless allow the applicator cap  210  to rotate relative to the preservation vial  2620 . Accordingly, when a user removes the applicator cap  210  by rotating the applicator cap  210  relative to the sensor applicator  102  ( FIGS.  29 A- 29 B ), the preservation vial  2620  may remain stationary relative to the cap post  3004 . 
     Upon removing the applicator cap  210  from the sensor applicator  102 , and thereby also separating the sensor control device  2602  from the applicator cap  210 , the shoulder  3104  defined on the enlarged head  2740  will engage the compliant feature(s)  3008  at the opening  3006 . Because the diameter of the shoulder  3104  is greater than the diameter of the opening  3006 , the shoulder  3104  will bind against the compliant feature(s)  3008  and thereby separate the preservation vial  2620  from the sensor control device  2602 , which exposes the distal portions of the sensor  2616  and the sharp  2618 . Accordingly, the compliant feature(s)  3008  may prevent the enlarged head  2740  from exiting the post chamber  3102  via the opening  3006  upon separating the applicator cap  210  from the sensor applicator  102  and the sensor control device  2602 . The separated preservation vial  2620  will fall into and remain within the post chamber  3102 . 
     In some embodiments, instead of the opening  3006  including the compliant feature(s)  3008 , as generally described above, the opening  3006  may alternatively be threaded. In such embodiments, a small portion near the distal end of the preservation vial  2620  may also be threaded and configured to threadably engage the threads of the opening  3006 . The preservation vial  2620  may be received within the post chamber  3102  via threaded rotation. Upon removing the applicator cap  210  from the sensor applicator  102 , however, the opposing threads on the opening  3006  and the preservation vial  2620  bind and the preservation vial  2620  may be separated from the sensor control device  2602 . 
     Accordingly, there are several advantages to incorporating the sensor control device  2602  into an analyte monitoring system (e.g., the analyte monitoring system  100  of  FIG.  1   ). Since the sensor control device  2602  is finally assembled in a controlled environment, tolerances can be reduced or eliminated altogether, which allows the sensor control device  2602  to be thin and small. Moreover, since the sensor control device  2602  is finally assembled in a controlled environment, a thorough pre-test of the sensor control device  2602  can be undertaken at the factory, thus fully testing the sensor unit prior to packaging for final delivery. 
     Embodiments disclosed herein include: 
     L. A sensor control device that includes an electronics housing, a plug assembly matable with the electronics housing and including a sensor module that has a sensor and a sharp module that has a sharp, and a preservation vial coupled to the plug assembly and defining an inner chamber, wherein distal portions of the sensor and the sharp are receivable within the inner chamber and isolated within the inner chamber from gaseous chemical sterilization. 
     M. An analyte monitoring system that includes a sensor applicator, a sensor control device positioned within the sensor applicator and including an electronics housing, a plug assembly coupled to the electronics housing and including a sensor module that has a sensor and a sharp module that has a sharp, and a preservation vial coupled to the plug assembly and defining an inner chamber. The analyte monitoring system further including a cap coupled to the sensor applicator to provide a barrier that seals the sensor control device within the sensor applicator, wherein distal portions of the sensor and the sharp are received within the inner chamber and isolated within the inner chamber from gaseous chemical sterilization. 
     N. A method of preparing an analyte monitoring system including loading a sensor control device into a sensor applicator, the sensor control device including an electronics housing, a plug assembly matable with the electronics housing and including a sensor module that has a sensor and a sharp module that has a sharp, and a preservation vial coupled to the plug assembly and defining an inner chamber. The method further including securing a cap to the sensor applicator and thereby providing a barrier that seals the sensor control device within the sensor applicator, sterilizing the sensor control device with gaseous chemical sterilization while the sensor control device is positioned within the sensor applicator, and isolating distal portions of the sensor and the sharp received within the inner chamber from the gaseous chemical sterilization. 
     Each of embodiments L, M, and N may have one or more of the following additional elements in any combination: Element 1: wherein the sensor module further includes a plug and the preservation vial is removably coupled to the plug. Element 2: wherein the preservation vial provides an enlarged head and a diameter of the enlarged head is greater than a diameter of remaining portions of the preservation vial. Element 3: further comprising a seal that provides a sealed barrier between the inner chamber and exterior to the inner chamber, wherein the distal portions of the sensor and the sharp penetrate the seal and extend into the inner chamber. Element 4: further comprising a preservation fluid within the inner chamber that isolates the distal portions of the sensor and the sharp from the gaseous chemical sterilization. Element 5: wherein the distal portions of the sensor and the sharp are at least partially immersed in the preservation fluid. Element 6: wherein the preservation fluid comprises an inert and biocompatible fluid selected from the group consisting of silicone oil, mineral oil, a gel, a wax, fresh water, salt water, a synthetic fluid, glycerol, sorbitan esters, and any combination thereof. Element 7: wherein the preservation fluid includes an anti-inflammatory agent. 
     Element 8: wherein the cap provides a cap post that defines a post chamber and an opening that receives an enlarged head of the preservation vial into the post chamber. Element 9: wherein the opening includes one or more compliant features that flex radially outward to receive the enlarged head. Element 10: wherein the one or more compliant features comprise a plurality of compliant fingers. Element 11: wherein the one or more compliant features prevent the enlarged head from exiting the post chamber through the opening upon separating the cap from the sensor applicator and the sensor control device. Element 12: wherein the cap is rotatable relative to the preservation vial when the preservation vial is received within the post chamber. Element 13: further comprising a preservation fluid within the inner chamber that isolates the distal portions of the sensor and the sharp from the gaseous chemical sterilization. 
     Element 14: wherein loading the sensor control device into a sensor applicator is preceded by assembling the plug assembly, coupling the preservation vial to the plug assembly such that the distal portions of the sensor and the sharp are received within the inner chamber, and coupling the plug assembly to an electronics housing and thereby providing the sensor control device. Element 15: wherein coupling the preservation vial to the plug assembly is preceded by sterilizing the plug assembly with radiation sterilization. Element 16: wherein isolating the distal portions of the sensor and the sharp from the gaseous chemical sterilization comprises at least partially immersing the distal portions of the sensor and the sharp within a preservation fluid present within the inner chamber. Element 17: wherein the cap provides a cap post that defines a post chamber having one or more compliant features arranged at an opening to the post chamber, and wherein securing the cap to the sensor applicator comprises receiving an enlarged head of the preservation vial into the post chamber via the opening, and flexing the one or more compliant features radially outward to receive the enlarged head. 
     By way of non-limiting example, exemplary combinations applicable to L, M, and N include: Element 4 with Element 5; Element 4 with Element 6; Element 4 with Element 7; Element 8 with Element 9; Element 9 with Element 10; Element 9 with Element 17; Element 8 with Element 12; Element 8 with Element 13; and Element 14 with Element 15. 
     Isolating One-Piece Sensor Design with Focused E-beam Sterilization 
       FIGS.  32 A and  32 B  are isometric and side views, respectively, of an example sensor control device  3202 , according to one or more embodiments of the present disclosure. The sensor control device  3202  (alternately referred to as a “puck”) may be similar in some respects to the sensor control device  104  of  FIG.  1    and therefore may be best understood with reference thereto. In some applications, the sensor control device  3202  may replace the sensor control device  104  of  FIG.  1    and, therefore, may be used in conjunction with the sensor applicator  102  ( FIG.  1   ), which delivers the sensor control device  3202  to a target monitoring location on a user&#39;s skin. 
     The sensor control device  3202 , however, may be incorporated into a one-piece system architecture in contrast to the sensor control device  104  of  FIG.  1   . Unlike the two-piece architecture, for example, a user is not required to open multiple packages and finally assemble the sensor control device  3202  before use. Rather, upon receipt by the user, the sensor control device  3202  is already fully assembled and properly positioned within the sensor applicator  102  ( FIG.  1   ). To use the sensor control device  3202 , the user need only open one barrier (e.g., removing the applicator cap  210  of  FIG.  2 B ) before promptly delivering the sensor control device  3202  to the target monitoring location. 
     As illustrated, the sensor control device  3202  includes an electronics housing  3204  that is generally disc-shaped and may have a circular cross-section. In other embodiments, however, the electronics housing  3204  may exhibit other cross-sectional shapes, such as ovoid or polygonal, without departing from the scope of the disclosure. The electronics housing  3204  may be configured to house or otherwise contain various electrical components used to operate the sensor control device  3202 . 
     The electronics housing  3204  may include a shell  3206  and a mount  3208  that is matable with the shell  3206 . The shell  3206  may be secured to the mount  3208  via a variety of ways, such as a snap fit engagement, an interference fit, sonic (or ultrasonic) welding, using one or more mechanical fasteners (e.g., screws), or any combination thereof. In some embodiments, the interface between the shell  3206  and the mount  3208  may be sealed. In such embodiments, a gasket or other type of seal material may be positioned or applied at or near the outer diameter (periphery) of the shell  3206  and the mount  3208 . Securing the shell  3206  to the mount  3208  may compress the seal material and thereby generate a sealed interface. In at least one embodiment, an adhesive may be applied to the outer diameter (periphery) of one or both of the shell  3206  and the mount  3208 , and the adhesive may not only secure the shell  3206  to the mount  3208  but may also seal the interface. 
     In embodiments where a sealed interface is created between the shell  3206  and the mount  3208 , the interior of the electronics housing  3204  may be effectively isolated from outside contamination between the two components. In such embodiments, if the sensor control device  3202  is assembled in a controlled and sterile environment, there may be no need to sterilize the internal electrical components (e.g., via gaseous chemical sterilization). Rather, the sealed engagement may provide a sufficient sterile barrier for the assembled electronics housing  3204 . 
     The sensor control device  3202  may further include a sensor module  3210  (partially visible in  FIG.  32 B ) and a sharp module  3212  (partially visible). The sensor and sharp modules  3210 ,  3212  may be interconnectable and coupled to the electronics housing  3204 . The sensor module  3210  may be configured to carry and otherwise include a sensor  3214  ( FIG.  32 B ), and the sharp module  3212  may be configured to carry and otherwise include a sharp  3216  ( FIG.  32 B ) used to help deliver the sensor  3214  transcutaneously under a user&#39;s skin during application of the sensor control device  3202 . 
     As illustrated in  FIG.  32 B , corresponding portions of the sensor  3214  and the sharp  3216  extend from the electronics housing  3204  and, more particularly, from the bottom of the mount  3208 . The exposed portion of the sensor  3214  may be received within a hollow or recessed portion of the sharp  3216 . The remaining portion(s) of the sensor  3214  is/are positioned within the interior of the electronics housing  3204 . 
     An adhesive patch  3218  may be positioned on and otherwise attached to the underside of the mount  3208 . Similar to the adhesive patch  108  of  FIG.  1   , the adhesive patch  3218  may be configured to secure and maintain the sensor control device  3202  in position on the user&#39;s skin during operation. In some embodiments, a transfer adhesive  3220  may interpose the adhesive patch  3218  and the bottom of the mount  3208 . The transfer adhesive  3220  may help facilitate the assembly process of the sensor control device  3202 . 
       FIGS.  33 A and  33 B  are exploded perspective top and bottom views, respectively, of the sensor control device  3202 , according to one or more embodiments. As illustrated, the shell  3206  and the mount  3208  of the electronics housing  3204  operate as opposing clamshell halves that enclose or otherwise substantially encapsulate the various electronic components of the sensor control device  3202 . 
     A printed circuit board (PCB)  3302  may be positioned within the electronics housing  3204 . As shown in  FIG.  33 B , a plurality of electronic modules  3304  may be mounted to the underside of the PCB  3302 . Example electronic modules  3304  include, but are not limited to, resistors, transistors, capacitors, inductors, diodes, and switches. A data processing unit  3306  ( FIG.  33 B ) may also be mounted to the PCB  3302  and may comprise, for example, an application specific integrated circuit (ASIC) configured to implement one or more functions or routines associated with operation of the sensor control device  3202 . More specifically, the data processing unit  3306  may be configured to perform data processing functions, such as filtering and encoding of data signals, each of which corresponds to a sampled analyte level of the user. The data processing unit  3306  may also include or otherwise communicate with an antenna for communicating with the reader device  106  ( FIG.  1   ). 
     As illustrated, the shell  3206 , the mount  3208 , and the PCB  3302  each define corresponding central apertures  3308   a ,  3308   b ,  3308   c , respectively. When the sensor control device  3202  is assembled, the central apertures  3308   a - c  coaxially align to receive portions of the sensor and sharp modules  3210 ,  3212  therethrough. 
     A battery  3310  and a corresponding battery mount  3312  may also be housed within the electronics housing  3204 . The battery  3310  may be configured to power the sensor control device  3202 . 
     The sensor module  3210  may include the sensor  3214  and a connector  3314 . The sensor  3214  includes a tail  3316 , a flag  3318 , and a neck  3320  that interconnects the tail  3316  and the flag  3318 . The tail  3316  may be configured to extend through the central aperture  3308   b  defined in the mount  3208  and extend distally from the underside thereof. The tail  3316  includes an enzyme or other chemistry or biologic and, in some embodiments, a membrane may cover the chemistry. In use, the tail  3316  is transcutaneously received beneath a user&#39;s skin, and the chemistry included thereon helps facilitate analyte monitoring in the presence of bodily fluids. 
     The flag  3318  may comprise a generally planar surface having one or more sensor contacts  3322  (three shown in  FIG.  33 A ) disposed thereon. The flag  3318  may be configured to be received within the connector  3314  where the sensor contact(s)  3322  align with a corresponding number of compliant carbon impregnated polymer modules (not shown) encapsulated within the connector  3314 . 
     The connector  3314  includes one or more hinges  3324  that enables the connector  3314  to pivot between open and closed states. The connector  3314  is depicted in  FIGS.  33 A- 33 B  in the closed state, but can transition to the open state to receive the flag  3318  and the compliant carbon impregnated polymer module(s) therein. The compliant carbon impregnated polymer module(s) provide electrical contacts  3326  (three shown in  FIG.  33 A ) configured to provide conductive communication between the sensor  3214  and corresponding circuitry contacts  3328  provided on the PCB  3302 . When the sensor module  3210  is properly coupled to the electronics housing  3204 , the circuitry contacts  3328  make conductive communication with the electrical contacts  3326  of the connector  3314 . The connector  3314  can be made of silicone rubber and may serve as a moisture barrier for the sensor  3214 . 
     The sharp module  3212  includes the sharp  3216  and a sharp hub  3330  that carries the sharp  3216 . The sharp  3216  includes an elongate shaft  3332  and a sharp tip  3334  at the distal end of the shaft  3332 . The shaft  3332  may be configured to extend through each of the coaxially aligned central apertures  3308   a - c  and extend distally from the bottom of the mount  3208 . Moreover, the shaft  3332  may include a hollow or recessed portion  3336  that at least partially circumscribes the tail  3316  of the sensor  3214 . The sharp tip  3334  may be configured to penetrate the skin while carrying the tail  3316  to put the active chemistry of the tail  3316  into contact with bodily fluids. 
     The sharp hub  3330  may include a hub small cylinder  3338  and a hub snap pawl  3340 , each of which may be configured to help couple the sensor control device  3202  to the sensor applicator  102  ( FIG.  1   ). 
     Referring specifically to  FIG.  33 A , in some embodiments the sensor module  3210  may be at least partially received within a sensor mount pocket  3342  included within the electronics housing  3204 . In some embodiments, the sensor mount pocket  3342  may comprise a separate structure, but may alternatively form an integral part or extension of the mount  3208 . The sensor mount pocket  3342  may be shaped and otherwise configured to receive and seat the sensor  3214  and the connector  3314 . As illustrated, the sensor mount pocket  3342  defines an outer periphery  3344  that generally circumscribes the region where the sensor  3214  and the connector  3314  are to be received. In at least one embodiment, the outer periphery  3344  may be sealed to the underside of the PCB  3302  when the electronics housing  3204  is fully assembled. In such embodiments, a gasket (e.g., an O-ring or the like), an adhesive, or another type of seal material may be applied (arranged) at the outer periphery  3344  and may operate to seal the interface between the sensor mount pocket  3342  and the PCB  3302 . 
     Sealing the interface between the sensor mount pocket  3342  and the underside of the PCB  3302  may help create or define a sealed zone or region within the electronics housing  3204 . The sealed region may prove advantageous in helping to isolate (protect) the tail  3316  of the sensor  3214  from potentially harmful sterilization gases used during gaseous chemical sterilization. 
     Referring specifically to  FIG.  33 B , a plurality of channels or grooves  3346  may be provided or otherwise defined on the bottom of the mount  3208 . As illustrated, the grooves  3346  may form a plurality of concentric rings in combination with a plurality of radially extending channels. The adhesive patch  3218  ( FIGS.  32 A- 32 B ) may be attached to the underside of the mount  3208 , and, in some embodiments, the transfer adhesive  3220  ( FIGS.  32 A- 32 B ) may interpose the adhesive patch  3218  and the bottom of the mount  3208 . The grooves  3346  may prove advantageous in promoting the egress of moisture away from the center of the electronics housing  3204  beneath the adhesive patch  3218 . 
     In some embodiments, a cap post seal interface  3348  may be defined on the bottom of the mount  3208  at the center of the mount  3208 . As illustrated, the cap post seal interface  3348  may comprise a substantially flat portion of the bottom of the mount  3208 . The second central aperture  3308   b  is defined at the center of the cap post seal interface  3348  and the grooves  3346  may circumscribe the cap post seal interface  3348 . The cap post seal interface  3348  may provide a sealing surface that may help isolate (protect) the tail  3316  of the sensor  3214  from potentially harmful sterilization gases used during gaseous chemical sterilization. 
       FIGS.  34 A and  34 B  are side and cross-sectional side views, respectively, of the sensor applicator  102  with the applicator cap  210  coupled thereto. More specifically,  FIGS.  34 A- 34 B  depict how the sensor applicator  102  might be shipped to and received by a user. According to the present disclosure, and as seen in  FIG.  34 B , the sensor control device  3202  is already assembled and installed within the sensor applicator  102  prior to being delivered to the user. The applicator cap  210  may be threaded to the housing  208  and include a tamper ring  3402 . Upon rotating (e.g., unscrewing) the applicator cap  210  relative to the housing  208 , the tamper ring  3402  may shear and thereby free the applicator cap  210  from the sensor applicator  102 . Following which, the user may deliver the sensor control device  3202  to the target monitoring location, as generally described above with reference to  FIGS.  2 E- 2 G . 
     With specific reference to  FIG.  34 B , the sensor control device  3202  may be loaded into the sensor applicator  102  by mating the sharp hub  3330  with a sensor carrier  3404  included within the sensor applicator  102 . More specifically, the hub small cylinder  3338  and the hub snap pawl  3340  may be received by corresponding mating features of the sensor carrier  3404 . 
     Once the sensor control device  3202  is mated with the sensor carrier  3404 , the applicator cap  210  may then be secured to the sensor applicator  102 . As illustrated, the applicator cap  210  may provide and otherwise define a cap post  3406  centrally located within the interior of the applicator cap  210  and extending proximally from the bottom thereof. The cap post  3406  may be configured to help support the sensor control device  3202  while contained within the sensor applicator  102 . Moreover, the cap post  3406  may define a post chamber  3408  configured to receive the sensor  3214  and the sharp  3216  as extending from the bottom of the electronics housing  3204 . When the sensor control device  3202  is loaded into the sensor applicator  102 , the sensor  3214  and the sharp  3216  may be arranged within a sealed region  3410  at least partially defined by the post chamber  3408  and configured to isolate the sensor  3214  and the sharp  3216  during gaseous chemical sterilization. 
     In some embodiments, prior to assembling and loading the sensor control device  3202  into the sensor applicator  102 , the sensor and sharp modules  3210 ,  3212  may be subjected to radiation sterilization to sterilize the distal portions of the sensor  3214  and the sharp  3216 . Once properly sterilized, the sensor and sharp modules  3210 ,  3212  may then be coupled to the electronics housing  3204  and the fully assembled sensor control device  3202  may then be loaded into the sensor applicator  102  as described above. 
     In other embodiments, however, the fully assembled sensor control device  3202  may first be loaded into the sensor applicator  102  and the sensor and sharp modules  3210 ,  3212  may then be subjected to radiation sterilization  3412  while positioned within the sensor applicator  102 . The radiation sterilization  3412  may comprise, for example, e-beam irradiation, but other methods of sterilization may alternatively be used including, but not limited to, gamma ray irradiation, X-ray irradiation, or any combination thereof. 
     In some embodiments, as illustrated, the sensor control device  3202  may be subjected to “focused” radiation sterilization  3412 , where the radiation (e.g., beams, waves, etc.) from the radiation sterilization  3412  is applied and otherwise directed only toward the sensor and sharp modules  3210 ,  3212  (e.g., the sensor  3214  and the sharp  3216 ). In such embodiments, the electrical components  3304  ( FIG.  33 B ) coupled to the PCB  3302  ( FIGS.  33 A- 33 B ), including the data processing unit  3306  ( FIG.  33 B ), may be positioned out of the range of the propagating radiation and, therefore, will not be affected by the radiation. The electrical components  3304  and the data processing unit  3306 , for example, may be positioned on the PCB  3302  near its outer periphery so as not to fall within the range (span) of the focused radiation sterilization  3412 . In other embodiments, this may be accomplished by shielding the sensitive electrical components  3304  with proper electromagnetic shields. 
     According to the present disclosure, while loaded in the sensor applicator  102 , the sensor control device  3202  may be subjected to gaseous chemical sterilization  3414  to sterilize the electronics housing  3204  and any other exposed portions of the sensor control device  3202 . To accomplish this, a chemical may be injected into a sterilization chamber  3416  cooperatively defined by the sensor applicator  102  and the interconnected cap  210 . In some applications, the chemical may be injected via one or more vents  3418  defined in the applicator cap  210  at its proximal end  3420 . Example chemicals that may be used for the gaseous chemical sterilization  3414  include, but are not limited to, ethylene oxide, vaporized hydrogen peroxide, and nitrogen oxide (e.g., nitrous oxide, nitrogen dioxide, etc.). 
     Since the sensor  3214  and the sharp  3216  are sealed within the sealed region  3410 , the chemicals used during the gaseous chemical sterilization process do not interact with the enzymes, chemistry or biologics provided on the tail  3316 . 
     Once a desired sterility assurance level has been achieved within the sterilization chamber  3416 , the gaseous solution is removed and the sterilization chamber  3416  is aerated. Aeration may be achieved by a series of vacuums and subsequently circulating nitrogen gas or filtered air through the sterilization chamber  3416 . Once the sterilization chamber  3416  is properly aerated, the vents  3418  may be occluded with a seal  3422  (shown in dashed lines) applied to the proximal end  3420  of the applicator cap  210 . 
     In some embodiments, the seal  3422  may comprise two or more layers of different materials. The first layer may be made of a synthetic material (e.g., a flash-spun high-density polyethylene fiber), such as Tyvek® available from DuPont®. Tyvek® is highly durable and puncture resistant and allows the permeation of vapors. The Tyvek® layer can be applied before the gaseous chemical sterilization  3414 , and following the gaseous chemical sterilization  3414 , a foil or other vapor and moisture resistant material layer may be sealed (e.g., heat sealed) over the Tyvek® layer to prevent the ingress of contaminants and moisture into the sterilization chamber  3416 . In other embodiments, the seal  3422  may comprise only a single protective layer applied to the applicator cap  210 . In such embodiments, the single layer is gas permeable for the sterilization process, but is also capable of protection against moisture and other harmful elements once the sterilization process is complete. 
     With the seal  3422  in place, the applicator cap  210  provides a barrier against outside contamination, and thereby maintains a sterile environment for the assembled sensor control device  3202  until the user removes (unthreads) the applicator cap  210 . The applicator cap  210  may also create a dust-free environment during shipping and storage that prevents the adhesive patch  3218  used to secure the sensor control device  3202  to the user&#39;s skin from becoming dirty. 
       FIG.  35    is an enlarged cross-sectional side view of the sensor control device  3202  mounted within the sensor applicator  102  with the applicator cap  210  secured thereto, according to one or more embodiments. As indicated above, portions of the sensor  3214  and the sharp  3216  may be arranged within the sealed region  3410  and thereby protected from substances that might adversely interact with the chemistry of the sensor  3214 . More specifically, the gases used during the gaseous chemical sterilization  3414  ( FIG.  34 B ) can adversely affect the enzymes provided on the tail  3316  of the sensor  3214 , and the sealed region  3410  protects the tail  3316  from the ingress of such chemicals. 
     As illustrated, the sealed region  3410  may include (encompass) select portions of the interior of the electronics housing  3204  and the post chamber  3408  of the cap post  3406 . In one or more embodiments, the sealed region  3410  may be defined and otherwise formed by at least a first seal  3502   a , a second seal  3502   b , and a third seal  3502   c . The first seal  3502   a  may be arranged to seal the interface between the sharp hub  3330  and the shell  3206 . Moreover, the first seal  3502   a  may circumscribe the first central aperture  3308   a  defined in the shell  3206  such that fluids (e.g., gaseous chemicals) are prevented from migrating into the interior of the electronics housing  3204  via the first central aperture  3308   a.    
     In some embodiments, the first seal  3502   a  may form part of the sharp hub  3330 . For example, the first seal  3502   a  may be overmolded onto the sharp hub  3330 . In other embodiments, the first seal  3502   a  may be overmolded onto the top surface of the shell  3206 . In yet other embodiments, the first seal  3502   a  may comprise a separate structure, such as an O-ring or the like, that interposes the sharp hub  3330  and the top surface of the shell  3206 , without departing from the scope of the disclosure. 
     The second seal  3502   b  may be arranged to seal the interface between the cap post  3406  and the bottom of the mount  3208 , and the second seal  3502   b  may circumscribe the second central aperture  3308   b  defined in the mount  3208 . Consequently, the second seal  3502   b  may prevent fluids (e.g., gaseous chemicals) from migrating into the post chamber  3408  of the cap post  3406  and also from migrating into the interior of the electronics housing  3204  via the second central aperture  3308   b.    
     In some embodiments, the second seal  3502   b  may form part of the cap post  3406 . For example, the second seal  3502   b  may be overmolded onto the top of the cap post  3406 . In other embodiments, the second seal  3502   b  may be overmolded onto the cap post seal interface  3348  at the bottom of the mount  3208 . In yet other embodiments, the second seal  3502   b  may comprise a separate structure, such as an O-ring or the like, that interposes the cap post  3406  and the bottom of the mount  3208 , without departing from the scope of the disclosure. 
     Upon loading the sensor control device  3202  into the sensor applicator  102  and securing the applicator cap  210  to the sensor applicator  102 , the first and second seals  3502   a,b  become compressed and generate corresponding sealed interfaces. The first and second seals  3502   a,b  may be made of a variety of materials capable of generating a sealed interface between opposing structures. Suitable materials include, but are not limited to, silicone, a thermoplastic elastomer (TPE), polytetrafluoroethylene (Teflon®), rubber, an elastomer, or any combination thereof. 
     The third seal  3502   c  may be arranged to seal an interface between the sensor mount pocket  3342  and the PCB  3302  and, more particularly, between the outer periphery  3344  of the sensor mount pocket  3342  and the underside of the PCB  3302 . The third seal  3502   c  may comprise a gasket (e.g., an O-ring or the like), an adhesive, or another type of seal material applied (arranged) at the outer periphery  3344 . In operation, the third seal  3502   c  may prevent fluids (e.g., gaseous chemicals, liquids, etc.) from migrating into the interior of the sensor mount pocket  3342  and, therefore, into the post chamber  3408  to adversely react with the enzymes on the tail  3316 . 
     The applicator cap  210  may be secured to the sensor applicator  102  by threading the applicator cap  210  to the sensor applicator  102  via relative rotation. As the applicator cap  210  rotates relative to the sensor applicator  102 , the cap post  3406  advances until the second seal  3502   b  engages the cap post seal interface  3348  at the bottom of the mount  3208 . Upon engaging the cap post seal interface  3348 , the second seal  3502   b  may frictionally engage the mount  3208  and thereby urge corresponding rotation of the entire electronics housing  3204  in the same angular direction. 
     In prior art sensor control devices, such as the sensor control device  104  of  FIG.  1   , conical carrier grip features are commonly defined on the exterior of the electronics housing and configured to mate with corresponding conical features provided on radially biased arms of the sensor mount pocket  3342 . Mating engagement between these corresponding conical features helps prevent the electronics housing from rotating within the sensor applicator  102 . 
     In contrast, the electronics housing  3204  of the presently disclosed sensor control device  3202  provides or otherwise defines an angled and otherwise continuously smooth exterior surface  3504  about its outer diameter (periphery). In some embodiments, as illustrated, the smooth exterior surface  3504  may be provided on the mount  3208 , but may alternatively be provided on the shell  3206 , without departing from the scope of the disclosure. One or more radially biased arms of the sensor mount pocket  3342  may be positioned to engage the exterior surface  3504  to help center the sensor control device  3202  within the sensor applicator  102 . As the electronics housing  3204  is urged to rotate through frictional engagement between the second seal  3502   b  and the bottom of the mount  3208 , the exterior surface  3504  slidingly engages the radially biased arms, which do not inhibit rotation thereof. 
       FIG.  36    is an enlarged cross-sectional bottom view of the sensor control device  3202  positioned atop the cap post  3406 , according to one or more embodiments. As illustrated, the adhesive patch  3218  is positioned on the underside of the mount  3208  and the transfer adhesive  3220  interposes the adhesive patch  3218  and the mount  3208 . 
     The adhesive patch  3218  may occlude or otherwise cover most of the grooves  3346  defined on the bottom of the mount  3208 . Moreover, as illustrated, the adhesive patch  3218  may extend a short distance into the cap post seal interface  3348 . To enable the grooves  3346  to properly direct moisture away from the center of the electronics housing  3204  and from the cap post seal interface  3348 , the adhesive patch  3218  (and the transfer adhesive  3220 , if included) may provide or otherwise define one or more channels  3602  aligned with and otherwise arranged to fluidly communicate with the grooves  3346 . In the illustrated embodiment, the channels  3602  extend radially outward from the center of the electronics housing  3204 , but may alternatively be defined in other configurations and nonetheless interconnect with the grooves  3346  to facilitate fluid communication therebetween. 
     In operation, as moisture builds up around the center of the electronics housing  3204  and at the cap post seal interface  3348 , the moisture is able to flow into the grooves  3346  via the channels  3602 . Once in the grooves  3346 , the moisture is able to flow radially outward beneath the adhesive patch  3218  and toward the outer periphery of the sensor control device  3202 . 
     Embodiments disclosed herein include: 
     O. An analyte monitoring system that includes a sensor applicator, a sensor control device positioned within the sensor applicator and including an electronics housing having a shell and a mount matable with the shell, a printed circuit board positioned within the electronics housing, a sensor extending from a bottom of the mount, a sharp hub positioned adjacent a top of the shell, and a sharp carried by the sharp hub and extending through the electronics housing and from the bottom of the mount. The analyte monitoring system further including a cap coupled to the sensor applicator and providing a cap post that defines a post chamber that receives the sensor and the sharp extending from the bottom of the mount, and a sealed region encompassing the post chamber and a portion of an interior of the electronics housing, wherein the sealed region is defined by a first seal that seals an interface between the sharp hub and the shell, a second seal that seals an interface between the cap post and the bottom of the mount, and a third seal that seals an interface between the mount and the printed circuit board, and wherein portions of the sensor and the sharp reside within the sealed region and are thereby isolated from gaseous chemical sterilization. 
     P. A method of preparing an analyte monitoring system including loading a sensor control device into a sensor applicator, the sensor control device including an electronics housing having a shell and a mount matable with the shell, a printed circuit board positioned within the electronics housing, a sensor module having a sensor extending from a bottom of the mount, and a sharp module having a sharp hub and a sharp carried by the sharp hub, wherein the sharp extends through the electronics housing and from the bottom of the mount. The method further including securing a cap to the sensor applicator, wherein the cap provides a cap post that defines a post chamber that receives the sensor and the sharp extending from the bottom of the mount, creating a sealed region as the cap is secured to the sensor applicator, the sealed region encompassing the post chamber and a portion of an interior of the electronics housing, wherein portions of the sensor and the sharp reside within the sealed region, sterilizing the sensor control device with gaseous chemical sterilization while the sensor control device is positioned within the sensor applicator, and isolating the portions of the sensor and the sharp residing within the sealed region from the gaseous chemical sterilization. 
     Each of embodiments O and P may have one or more of the following additional elements in any combination: Element 1: wherein the first seal circumscribes a central aperture defined in the shell and prevents fluids from migrating into the portion of the interior of the electronics housing via the central aperture. Element 2: wherein the second seal circumscribes a central aperture defined in the mount and prevents fluids from migrating into the portion of the interior of the electronics housing via the central aperture and further prevents the fluids from migrating into the post chamber. Element 3: wherein the first seal is overmolded onto the sharp hub. Element 4: wherein the first seal interposes the sharp hub and a top surface of the shell. Element 5: wherein the second seal is overmolded onto the cap post. Element 6: wherein the second seal interposes the cap post and a bottom surface of the mount. Element 7: wherein the first and second seals are made of a material selected from the group consisting of silicone, a thermoplastic elastomer, polytetrafluoroethylene, and any combination thereof. Element 8: wherein the mount provides a sensor mount pocket that at least partially receives a sensor module within the electronics housing, and wherein the third seal is positioned at an outer periphery of the sensor mount pocket. Element 9: wherein the third seal comprises one of a gasket and an adhesive. Element 10: further comprising a plurality of grooves defined on the bottom of the mount, and a cap post seal interface defined on the bottom of the mount at a center of the mount, wherein the second seal seals against the cap post seal interface. Element 11: further comprising an adhesive patch coupled to the bottom of the mount and extending radially into the cap post seal interface, and one or more channels defined in the adhesive patch and interconnecting with the plurality of grooves to facilitate fluid communication between the cap post seal interface and the plurality of grooves. Element 12: wherein the electronics housing defines an angled and smooth exterior surface that allows the sensor control device to rotate unobstructed relative to the sensor applicator as the cap is coupled to the sensor applicator. 
     Element 13: wherein creating the sealed region as the cap is secured to the sensor applicator comprises sealing an interface between the sharp hub and the shell with a first seal, sealing an interface between the cap post and the bottom of the mount with a second seal, and sealing an interface between the mount and the printed circuit board with a third seal. Element 14: wherein loading the sensor control device into a sensor applicator is preceded by sterilizing the sensor and the sharp with radiation sterilization, and assembling the sensor and sharp modules to the electronics housing. Element 15: wherein sterilizing the sensor control device with the gaseous chemical sterilization is preceded by sterilizing the sensor and the sharp with radiation sterilization while the sensor control device is positioned within the sensor applicator. Element 16: wherein the radiation sterilization is at least one of focused radiation sterilization and low-energy radiation sterilization. Element 17: wherein the electronics housing defines an angled and smooth exterior surface, the method further comprising allowing the sensor control device to rotate relative to the sensor applicator as the cap is secured to the sensor applicator. 
     By way of non-limiting example, exemplary combinations applicable to O and P include: Element 1 with Element 2; Element 1 with Element 3; Element 1 with Element 4; Element 1 with Element 5; Element 1 with Element 6; Element 1 with Element 7; Element 1 with Element 8; Element 3 with Element 4; Element 3 with Element 5; Element 3 with Element 6; Element 10 with Element 11; and Element 15 with Element 16. 
     One-Piece Puck Architecture with ASIC Shields, Use of Low and Medium Energy Radiation Sterilization, and Magnetic Deflection 
       FIGS.  37 A- 37 C  are isometric, side, and bottom views, respectively, of an example sensor control device  3702 , according to one or more embodiments of the present disclosure. The sensor control device  3702  (alternately referred to as an on-body patch or unit) may be similar in some respects to the sensor control device  104  of  FIG.  1    and therefore may be best understood with reference thereto. The sensor control device  3702  may replace the sensor control device  104  of  FIG.  1    and, therefore, may be used in conjunction with the sensor applicator  102  ( FIG.  1   ), which delivers the sensor control device  3702  to a target monitoring location on a user&#39;s skin. However, in contrast to the sensor control device  104  of  FIG.  1   , various structural advantages and improvements allow the sensor control device  3702  to be incorporated into a one-piece system architecture. 
     Unlike the sensor control device  104  of  FIG.  1   , for example, a user is not required to open multiple packages and finally assemble the sensor control device  3702  prior to delivery to the target monitoring location. Rather, upon receipt by the user, the sensor control device  3702  may already be assembled and properly positioned within the sensor applicator  102 . To use the sensor control device  3702 , the user need only break one barrier (e.g., the applicator cap  210  of  FIG.  2 B ) before promptly delivering the sensor control device  3702  to the target monitoring location. 
     Referring first to  FIG.  37 A , the sensor control device  3702  comprises an electronics housing  3704  that is generally disc-shaped and may have a generally circular cross-section. In other embodiments, however, the electronics housing  3704  may exhibit other cross-sectional shapes, such as ovoid or polygonal, without departing from the scope of the disclosure. The electronics housing  3704  may include a shell  3706  and a mount  3708  that is matable with the shell  3706 . An adhesive patch  3710  may be positioned on and otherwise attached to the underside of the mount  3708 . Similar to the adhesive patch  108  of  FIG.  1   , the adhesive patch  3710  may be configured to secure and maintain the sensor control device  3702  in position on the user&#39;s skin during operation. 
     In some embodiments, the shell  3706  may define a reference feature  3712 . As illustrated, the reference feature  3712  may comprise a depression or blind pocket defined in the shell  3706  and extending a short distance into the interior of the electronics housing  3704 . The reference feature  3712  may operate as a “datum c” feature configured to help facilitate control of the sensor control device  3702  in at least one degree of freedom during factory assembly. In contrast, prior sensor control devices (e.g., the sensor control device  104  of  FIG.  1   ) typically include a tab extending radially from the side of the shell. The tab is used as an in-process clocking datum, but must be removed at the end of fabrication, and followed by an inspection of the shell where the tab once existed, which adds complexity to the prior fabrication process. 
     The shell  3706  may also define a central aperture  3714  sized to receive a sharp (not shown) that is extendable through the center of the electronics housing  3704 . 
       FIG.  37 B  depicts a portion of a sensor  3716  extending from the electronics housing  3704 . The remaining portion(s) of the sensor  3716  is/are positioned within the interior of the electronics housing  3704 . Similar to the sensor  110  of  FIG.  1   , the exposed portion of the sensor  3716  is configured to be transcutaneously positioned under the user&#39;s skin during use. The exposed portion of the sensor  3716  can include an enzyme or other chemistry or biologic and, in some embodiments, a membrane may cover the chemistry. 
     The sensor control device  3702  provides structural improvements that result in a height H and a diameter D that may be less than prior sensor control devices (e.g., the sensor control device  104  of  FIG.  1   ). In at least one embodiment, for example, the height H may be about 1 mm or more less than the height of prior sensor control devices, and the diameter D may be about 2 mm or more less than the diameter of prior sensor control devices. 
     Moreover, the structural improvements of the sensor control device  3702  allows the shell  3706  to provide or otherwise define a chamfered or angled outer periphery  3718 . In contrast, prior sensor control devices commonly require a rounded or outwardly arcuate outer periphery to accommodate internal components. The reduced height H, the reduced diameter D, and the angled outer periphery  3718  may each prove advantageous in providing a sensor control device  3702  that is thinner, smaller, and less prone to being prematurely detached by catching on sharp corners or the like while attached to the user&#39;s skin. 
       FIG.  37 C  depicts a central aperture  3720  defined in the underside of the mount  3708 . The central aperture  3720  may be sized to receive a combination sharp (not shown) and sensor  3716 , where the sensor  3716  is received within a hollow or recessed portion of the sharp. When the electronics housing  3704  is assembled, the central aperture  3720  coaxially aligns with the central aperture  3714  ( FIG.  37 A ) of the shell  3706  ( FIG.  37 A ) and the sharp penetrates the electronics housing by extending simultaneously through each central aperture  3714 ,  3720 . 
       FIGS.  38 A and  38 B  are exploded top and bottom views, respectively, of the sensor control device  3702 , according to one or more embodiments. The shell  3706  and the mount  3708  operate as opposing clamshell halves that enclose or otherwise substantially encapsulate the various electronic components of the sensor control device  3702 . As illustrated, the sensor control device  3702  may include a printed circuit board assembly (PCBA)  3802  that includes a printed circuit board (PCB)  3804  having a plurality of electronic modules  3806  coupled thereto. Example electronic modules  3806  include, but are not limited to, resistors, transistors, capacitors, inductors, diodes, and switches. Prior sensor control devices commonly stack PCB components on only one side of the PCB. In contrast, the PCB components  3806  in the sensor control device  3702  can be dispersed about the surface area of both sides (i.e., top and bottom surfaces) of the PCB  3804 . 
     Besides the electronic modules  3806 , the PCBA  3802  may also include a data processing unit  3808  mounted to the PCB  3804 . The data processing unit  3808  may comprise, for example, an application specific integrated circuit (ASIC) configured to implement one or more functions or routines associated with operation of the sensor control device  3702 . More specifically, the data processing unit  3808  may be configured to perform data processing functions, where such functions may include but are not limited to, filtering and encoding of data signals, each of which corresponds to a sampled analyte level of the user. The data processing unit  3808  may also include or otherwise communicate with an antenna for communicating with the reader device  106  ( FIG.  1   ). 
     A battery aperture  3810  may be defined in the PCB  3804  and sized to receive and seat a battery  3812  configured to power the sensor control device  3702 . An axial battery contact  3814   a  and a radial battery contact  3814   b  may be coupled to the PCB  3804  and extend into the battery aperture  3810  to facilitate transmission of electrical power from the battery  3812  to the PCB  3804 . As their names suggest, the axial battery contact  3814   a  may be configured to provide an axial contact for the battery  3812 , while the radial battery contact  3814   b  may provide a radial contact for the battery  3812 . Locating the battery  3812  within the battery aperture  3810  with the battery contacts  3814   a,b  helps reduce the height H ( FIG.  37 B ) of the sensor control device  3702 , which allows the PCB  3804  to be located centrally and its components to be dispersed on both sides (i.e., top and bottom surfaces). This also helps facilitate the chamfer  3718  ( FIG.  37 B ) provided on the electronics housing  3704 . 
     The sensor  3716  may be centrally located relative to the PCB  3804  and include a tail  3816 , a flag  3818 , and a neck  3820  that interconnects the tail  3816  and the flag  3818 . The tail  3816  may be configured to extend through the central aperture  3720  of the mount  3708  to be transcutaneously received beneath a user&#39;s skin. Moreover, the tail  3816  may have an enzyme or other chemistry included thereon to help facilitate analyte monitoring. 
     The flag  3818  may include a generally planar surface having one or more sensor contacts  3822  (three shown in  FIG.  38 B ) arranged thereon. The sensor contact(s)  3822  may be configured to align with and engage a corresponding one or more circuitry contacts  3824  (three shown in  FIG.  38 A ) provided on the PCB  3804 . In some embodiments, the sensor contact(s)  3822  may comprise a carbon impregnated polymer printed or otherwise digitally applied to the flag  3818 . Prior sensor control devices typically include a connector made of silicone rubber that encapsulates one or more compliant carbon impregnated polymer modules that serve as electrical conductive contacts between the sensor and the PCB. In contrast, the presently disclosed sensor contacts(s)  3822  provide a direct connection between the sensor  3716  and the PCB  3804  connection, which eliminates the need for the prior art connector and advantageously reduces the height H ( FIG.  37 B ). Moreover, eliminating the compliant carbon impregnated polymer modules eliminates a significant circuit resistance and therefor improves circuit conductivity. 
     The sensor control device  3702  may further include a compliant member  3826 , which may be arranged to interpose the flag  3818  and the inner surface of the shell  3706 . More specifically, when the shell  3706  and the mount  3708  are assembled to one another, the compliant member  3826  may be configured to provide a passive biasing load against the flag  3818  that forces the sensor contact(s)  3822  into continuous engagement with the corresponding circuitry contact(s)  3824 . In the illustrated embodiment, the compliant member  3826  is an elastomeric O-ring, but could alternatively comprise any other type of biasing device or mechanism, such as a compression spring or the like, without departing from the scope of the disclosure. 
     The sensor control device  3702  may further include one or more electromagnetic shields, shown as a first shield  3828   a  and a second shield  3828   b . The shields  3828   a,b  may be arranged between the shell  3706  and the mount  3708 ; i.e., within the electronics housing  3704  ( FIGS.  37 A- 37 B ). In the illustrated embodiment, the first shield  3828   a  is arranged above the PCB  3804  such that it faces the top surface of the PCB  3804 , and the second shield  3828   b  is arranged below the PCB  3804  such that it faces the bottom surface of the PCB  3804 . 
     The shields  3828   a,b  may be configured to protect sensitive electronic components from radiation while the sensor control device  3702  is subjected to radiation sterilization. More specifically, at least one of the shields  3828   a,b  may be positioned to interpose the data processing unit  3808  and a radiation source, such as an e-beam electron accelerator. In some embodiments, for example, at least one of the shields  3828   a,b  may be positioned adjacent to and otherwise aligned with the data processing unit  3808  and the radiation source to block or mitigate radiation absorbed dose that might otherwise damage the sensitive electronic circuitry of the data processing unit  3808 . 
     In the illustrated embodiment, the data processing unit  3808  interposes the first and second shields  3828   a,b  such that the first and second shields  3828   a,b  essentially bookend the data processing unit  3808  in the axial direction. In at least one embodiment, however, only one of the shields  3828   a,b  may be necessary to properly protect the data processing unit  3808  during radiation sterilization. For example, if the sensor control device  3702  is subjected to radiation sterilization directed toward the bottom of the mount  3708 , only the second shield  3828   b  may be needed to interpose the data processing unit  3808  and the radiation source, and the first shield  3828   a  may be omitted. Alternatively, if the sensor control device  3702  is subjected to radiation sterilization directed toward the top of the shell  3706 , only the first shield  3828   a  may be needed to interpose the data processing unit  3808  and the radiation source, and the second shield  3828   b  may be omitted. In other embodiments, however, both shields  3828   a,b  may be employed, without departing from the scope of the disclosure. 
     The shields  3828   a,b  may be made of any material capable of attenuating (or substantially attenuating) the transmission of radiation. Suitable materials for the shields  3828   a,b  include, but are not limited to, lead, tungsten, iron-based metals (e.g., stainless steel), copper, tantalum, tungsten, osmium, aluminum, carbon, or any combination thereof. Suitable metals for the shields  3828   a,b  may be corrosion-resistant, austenitic, and any non-magnetic metal with a density ranging between about 2 grams per cubic centimeter (g/cc) and about 23 g/cc. The shields  3828   a,b  may be fabricated via a variety of manufacturing techniques including, but not limited to, stamping, casting, injection molding, sintering, two-shot molding, or any combination thereof. 
     In other embodiments, however, the shields  3828   a,b  may comprise a metal-filled thermoplastic polymer such as, but not limited to, polyamide, polycarbonate, or polystyrene. In such embodiments, the shields  3828   a,b  may be fabricated by mixing the shielding material in an adhesive matrix and dispensing the combination onto shaped components or otherwise directly onto the data processing unit  3808 . Moreover, in such embodiments, the shields  3828   a,b  may comprise an enclosure that encapsulates (or substantially encapsulates) the data processing unit  3808 . In such embodiments, the shields  3828   a,b  may comprise a metal-filled thermoplastic polymer, as mentioned above, or may alternatively be made of any of the materials mentioned herein that are capable of attenuating (or substantially attenuating) the transmission of radiation. 
     The shell  3706  may provide or otherwise define a first clocking receptacle  3830   a  ( FIG.  38 B ) and a second clocking receptacle  3830   b  ( FIG.  38 B ), and the mount  3708  may provide or otherwise define a first clocking post  3832   a  ( FIG.  38 A ) and a second clocking post  3832   b  ( FIG.  38 A ). Mating the first and second clocking receptacles  3830   a,b  with the first and second clocking posts  3832   a,b , respectively, will properly align the shell  3706  to the mount  3708 . 
     Referring specifically to  FIG.  38 A , the inner surface of the mount  3708  may provide or otherwise define a plurality of pockets or depressions configured to accommodate various component parts of the sensor control device  3702  when the shell  3706  is mated to the mount  3708 . For example, the inner surface of the mount  3708  may define a battery locator  3834  configured to accommodate a portion of the battery  3812  when the sensor control device  3702  is assembled. An adjacent contact pocket  3836  may be configured to accommodate a portion of the axial contact  3814   a.    
     Moreover, a plurality of module pockets  3838  may be defined in the inner surface of the mount  3708  to accommodate the various electronic modules  3806  arranged on the bottom of the PCB  3804 . Furthermore, a shield locator  3840  may be defined in the inner surface of the mount  3708  to accommodate at least a portion of the second shield  3828   b  when the sensor control device  3702  is assembled. The battery locator  3834 , the contact pocket  3836 , the module pockets  3838 , and the shield locator  3840  all extend a short distance into the inner surface of the mount  3708  and, as a result, the overall height H ( FIG.  37 B ) of the sensor control device  3702  may be reduced as compared to prior sensor control devices. The module pockets  3838  may also help minimize the diameter of the PCB  3804  by allowing PCB components to be arranged on both sides (i.e., top and bottom surfaces). 
     Still referring to  FIG.  38 A , the mount  3708  may further include a plurality of carrier grip features  3842  (two shown) defined about the outer periphery of the mount  3708 . The carrier grip features  3842  are axially offset from the bottom  3844  of the mount  3708 , where a transfer adhesive (not shown) may be applied during assembly. In contrast to prior sensor control devices, which commonly include conical carrier grip features that intersect with the bottom of the mount, the presently disclosed carrier grip features  3842  are offset from the plane (i.e., the bottom  3844 ) where the transfer adhesive is applied. This may prove advantageous in helping ensure that the delivery system does not inadvertently stick to the transfer adhesive during assembly. Moreover, the presently disclosed carrier grip features  3842  eliminate the need for a scalloped transfer adhesive, which simplifies the manufacture of the transfer adhesive and eliminates the need to accurately clock the transfer adhesive relative to the mount  3708 . This also increases the bond area and, therefore, the bond strength. 
     Referring to  FIG.  38 B , the bottom  3844  of the mount  3708  may provide or otherwise define a plurality of grooves  3846 , which may be defined at or near the outer periphery of the mount  3708  and equidistantly spaced from each other. A transfer adhesive (not shown) may be coupled to the bottom  3844  and the grooves  3846  may be configured to help convey (transfer) moisture away from the sensor control device  3702  and toward the periphery of the mount  3708  during use. In some embodiments, the spacing of the grooves  3846  may interpose the module pockets  3838  ( FIG.  38 A ) defined on the opposing side (inner surface) of the mount  3708 . As will be appreciated, alternating the position of the grooves  3846  and the module pockets  3838  ensures that the opposing features on either side of the mount  3708  do not extend into each other. This may help maximize usage of the material for the mount  3708  and thereby help maintain a minimal height H ( FIG.  37 B ) of the sensor control device  3702 . The module pockets  3838  may also significantly reduce mold sink, and improve the flatness of the bottom  3844  that the transfer adhesive bonds to. 
     Still referring to  FIG.  38 B , the inner surface of the shell  3706  may also provide or otherwise define a plurality of pockets or depressions configured to accommodate various component parts of the sensor control device  3702  when the shell  3706  is mated to the mount  3708 . For example, the inner surface of the shell  3706  may define an opposing battery locator  3848  arrangeable opposite the battery locator  3834  ( FIG.  38 A ) of the mount  3708  and configured to accommodate a portion of the battery  3812  when the sensor control device  3702  is assembled. Moreover, a shield locator  3850  may be defined in the inner surface of the shell  3706  to accommodate at least a portion of the first shield  3828   a  when the sensor control device  3702  is assembled. The opposing battery locator  3848  and the shield locator  3850  extend a short distance into the inner surface of the shell  3706 , which helps reduce the overall height H ( FIG.  37 B ) of the sensor control device  3702 . 
     A sharp and sensor locator  3852  may also be provided by or otherwise defined on the inner surface of the shell  3706 . The sharp and sensor locator  3852  may be configured to receive both the sharp (not shown) and a portion of the sensor  3716 . Moreover, the sharp and sensor locator  3852  may be configured to align and/or mate with a corresponding sharp and sensor locator  2054  ( FIG.  38 A ) provided on the inner surface of the mount  3708 . 
       FIGS.  39 A- 39 D  show progressive example assembly of the sensor control device  3702 , according to one or more embodiments. In  FIG.  39 A , the battery  3812  has been loaded into the opposing battery locator  3848  and the first shield  3828   a  has been loaded into the shield locator  3850  defined in the inner surface of the shell  3706 . The compliant member  3826  and the flag  3818  of the sensor  3716  may each be mounted to the first clocking receptacle  3830   a . The tail  3816  of the sensor  3716  may be inserted into the sharp and the sensor locator  3852 . 
     In  FIG.  39 B , the PCB  3804  may be loaded into the shell  3706  to align the battery aperture  3810  with the battery  3812  and the axial and radial battery contacts  3814   a,b  facilitate electrical communication. 
     In  FIG.  39 C , the second shield  3828   b  has been loaded into the shield locator  3840  defined in the inner surface of the mount  3708 . The mount  3708  is now ready to be coupled to the shell  3706  ( FIGS.  39 A and  39 B ). To accomplish this, the first and second clocking receptacles  3830   a,b  ( FIG.  39 B ) of the shell  3706  may be coaxially aligned with the first and second clocking posts  3832   a,b  of the mount  3708 , respectively. An adhesive may be applied to one or both of the shell  3706  and the mount  3708  to secure the two components together. In one embodiment, for example, the adhesive may be applied around the outer diameter (periphery) of the shell  3706 , and the shell  3706  may then be transferred to the mount  3708  and mated with the corresponding outer diameter (periphery) of the mount  3708 . In other embodiments, the adhesive may be applied around the outer diameter (periphery) of the mount  3708  or the outer diameter (periphery) of both the shell  3706  and the mount  3708 , without departing from the scope of the disclosure. In at least one embodiment, an adhesive may be used to secure the first and second clocking receptacles  3830   a,b  to the first and second clocking posts  3832   a,b , respectively. 
       FIG.  39 D  shows the assembled sensor control device  3702 , which may be tested to ensure the sensor  3716  and the corresponding electronics of the sensor control device  3702  function properly. The adhesive may not only secure the shell  3706  to the mount  3708  and provide structural integrity, but may also seal the interface between the two components and thereby isolate the interior of the electronics housing  3704  from outside contamination. Consequently, there may be no need to sterilize the internal electrical components of the sensor control device  3702  via gaseous chemical sterilization (e.g., ethylene oxide). Rather, the adhesive provides a sterile and moisture barrier to the interior of the assembled sensor control device  3702 . 
     The adhesive patch  3710  may be applied to the bottom  3844  of the mount  3708 . In some embodiments, the adhesive patch  3710  may have a removable release liner that is removed to enable the adhesive patch  3710  to be attached to the bottom  3844  of the mount  3708 . 
     Either before or after securing the adhesive patch  3710 , a sharp module  3904  may be coupled to the sensor control device  3702 . As illustrated, the sharp module  3904  may include a sharp hub  3906  and a sharp  3908  carried by the sharp hub  3906  and extending through the electronics housing  3704 . To couple the sharp module  3904  to the sensor control device  3702 , a sharp tip  3910  of the sharp  3908  may be extended through the coaxially aligned central apertures  3714 ,  3720  ( FIGS.  37 A and  37 C ) of the shell  3706  and the mount  3708 , respectively. As the sharp tip  3910  penetrates the sensor control device  3702 , the tail  3816  may be received within a hollow or recessed portion of the sharp tip  3910 . The sharp tip  3910  may be configured to penetrate the skin while carrying the tail  3816  to put the active chemistry present on the tail  3816  into contact with bodily fluids. 
     The sharp tip  3910  may be advanced through the sensor control device  3702  until the sharp hub  3906  engages the upper surface of the shell  3706 . As illustrated, the sharp hub  3906  may include a hub small cylinder  3912  and a hub snap pawl  3914 , each of which may be configured to help couple the sensor control device  3702  to a sensor applicator (e.g., the sensor applicator  102  of  FIG.  1   ). 
       FIGS.  40 A and  40 B  are side and cross-sectional side views, respectively, of the sensor applicator  102  sealed with the applicator cap  210 . According to the present disclosure, and as seen in  FIG.  40 B , the sensor control device  3702  may already be assembled, as generally described above, and installed within the sensor applicator  102  prior to being delivered to a user. Accordingly,  FIGS.  40 A- 40 B  depict how the sensor applicator  102  might be shipped to and received by the user. 
     The applicator cap  210  may be configured to provide a barrier against outside contamination, and thereby maintains a sterile environment for the assembled sensor control device  3702  positioned within the sensor applicator  102 . The applicator cap  210  may also create a dust-free environment during shipping and storage that prevents the adhesive patch  3710  ( FIG.  40 B ) from becoming dirty. The applicator cap  210  may be threaded to the housing  208  and include a tamper ring  4002 . Upon rotating (e.g., unscrewing) the applicator cap  210  relative to the housing  208 , the tamper ring  4002  may shear and thereby free the applicator cap  210  from the sensor applicator  102 . 
     As shown in  FIG.  40 B , the sensor  3716  and the sharp  3908  are already incorporated into the assembled sensor control device  3702 . Consequently, there is no need for a two-piece architecture system that requires the sensor tray  202  ( FIG.  2   ) or a user to finally assemble the sensor control device  3702  as shown in and described with reference to  FIGS.  2 A- 2 D . Rather, according to the present disclosure, the sensor control device  3702  may be fully sterilized while loaded in the sensor applicator  102  prior to being packaged for shipment to a user. 
     More specifically, the sensor control device  3702  may be subjected to radiation sterilization  4004  while loaded (positioned) within the sensor applicator  102  to sterilize the sensor  3716  and the sharp  3908 . The radiation sterilization  4004  may comprise, for example, e-beam irradiation, but other methods of sterilization may alternatively be used including, but not limited to, gamma ray irradiation, low energy X-ray irradiation, or any combination thereof. 
     In some embodiments, as illustrated, the radiation sterilization  4004  may be applied to the sensor control device  3702  through the applicator cap  210  and otherwise through a proximal end  4006  of the applicator cap  210 . The applicator cap  210  may be made of any material that allows radiation to pass therethrough. In at least one embodiment, for example, cap  210  may be made of a thermoplastic. The radiation sterilization  4004  may propagate through the applicator cap  210  and impinge upon the sensor control device  3702  to inactivate or kill microorganisms or other contaminants that may be present on the sensor  3716  and the sharp  3908 . 
     In some embodiments, the radiation sterilization  4004  may comprise electron beam (e-beam) irradiation. E-beam irradiation is a penetrating process that allows the sensor control device  3702  to be already mounted within the sensor applicator  102  before the irradiation process. By sterilizing the sensor control device  3702  after it has been packaged, the possibility of contamination during the time between sterilization and packaging is reduced. 
       FIGS.  41 A and  41 B  are enlarged cross-sectional views of the sensor control device  3702  during example radiation sterilization  4004 , according to one or more embodiments of the present disclosure. In one aspect, one or more e-beam accelerators may be used to generate the radiation sterilization  4004  and, more particularly, to accelerate electrons into a concentrated highly charged electron stream. As materials pass through the stream of electrons, energy from the stream is absorbed and the absorption of this energy alters chemical and biological bonds. At certain levels of absorption, also known as the “absorbed dose,” DNA chains and reproductive cells of microorganisms are destroyed, and thereby effectively sterilizing the target device or package. The irradiation dosage is important, as too low of a dosage may not result in complete sterilization, while too high of a dosage may result in adverse effects on the materials of the sensor control device  3702  and the packaging (the applicator cap  210  of  FIG.  40 B ) being sterilized. 
     The electromagnetic shields  3828   a,b  included within the sensor control device  3702  may prove advantageous in shielding and otherwise protecting sensitive electronic components, such as the data processing unit  3808 , while the sensor control device  3702  is subjected to the radiation sterilization  4004 . 
     In  FIG.  41 A , one or both of the first and second shields  3828   a,b  may help shield the data processing unit  3808  from the absorbed dose of radiation from the radiation sterilization  4004 . More specifically, the electromagnetic shields  3828   a,b  may be aligned with and otherwise positioned to block or otherwise mitigate radiation exposure that might otherwise damage the data processing unit  3808 . In the illustrated embodiment, the radiation energy of the radiation sterilization  4004  propagates normal to the data processing unit  3808 , and at least the second shield  3828   b  interposes the data processing unit  3808  and the source of the radiation sterilization  4004 . 
     In  FIG.  41 B , the first shield  3828   a  covers and otherwise encapsulates the data processing unit  3808  and thereby helps shield the data processing unit  3808  from the absorbed dose of radiation from the radiation sterilization  4004 . More specifically, by forming an enclosure around the data processing unit  3808 , the first shield  3828   a  may be positioned to block or otherwise mitigate radiation exposure that might otherwise damage the data processing unit  3808 . In such embodiments, the second shield  3828   b  may not be necessary. 
     The e-beam irradiation process of the radiation sterilization  4004  may include a continuous exposure or an intermittent exposure, and the e-beam accelerator may be of a continuous or a varying power, depending upon available machinery and determinations to achieve the desired internal and surface dosage limitations. The penetration power of e-beam irradiation correlates to the density of the underlying material being subjected to the radiation sterilization  4004  and the energy level of the e-beam accelerator. The larger and denser the material, the higher the energy the e-beam accelerator must output to achieve full penetration. 
       FIG.  42    is a plot  4200  that graphically depicts an approximation of penetration depth as a function of the energy level of e-beam radiation sterilization for unit density materials such as water. As indicated by the plot  4200 , the higher the energy level of the electrons of the e-beam radiation sterilization, the deeper the radiation will penetrate into a selected material. Most standard e-beam sterilization processes operate at a 10 mega electron-volt (MeV) energy level which, according to the plot  4200 , will penetrate into a given material about 3.8 cm for a unit density material such as water (density=1 g/cc). 
     According to embodiments of the present disclosure, e-beam sterilization (e.g., the radiation sterilization  4004  of  FIGS.  40 B and  41 A- 41 B ) may be undertaken at lower energy levels and nonetheless achieve comparable or commensurate sterilization dose achieved at high energy levels (e.g., 10 MeV or more). In some embodiments, for example, radiation sterilization may be undertaken at an energy level ranging between about 0.5 MeV and about 3.0 MeV and can achieve an equivalent dose to irradiating at higher energy levels. In yet other embodiments, the radiation sterilization may be undertaken at an energy level as low as 0.1 MeV, without departing from the scope of the disclosure. 
     According to the plot  4200 , dosing at an energy level ranging between about 0.5 MeV and about 3.0 MeV equates to a penetration depth ranging between about 0.2 cm and about 1.0 cm for a material with density of 1 g/cc. Accordingly, at lower energy levels, it may be possible to shield sensitive electronic components with high density materials and small thicknesses such that little or no radiation penetrates the shield. 
     In view of the foregoing, the material and configuration of the shields  3828   a,b  ( FIGS.  41 A- 41 B ) may be selected and optimized (tuned) in view of low energy radiation sterilization to protect the data processing unit  3808  ( FIGS.  41 A- 41 B ). The penetration depth for a given material may be determined for example in the range of 0.2 to 2.0 MeV, by Equation (1) below obtained from ISO/ASTM 51649: 2005(E) “Standard Practice for Dosimetry in an Electron Beam Facility for Radiation Processing at Energies between 300 keV and 25 MeV.” 
     
       
         
           
             
               
                 
                   Rp 
                   = 
                   
                     
                       ( 
                       
                         
                           
                             0 
                             . 
                             5 
                           
                           ⁢ 
                           0 
                           ⁢ 
                           7 
                           ⁢ 
                           E 
                         
                         - 
                         
                           
                             0 
                             . 
                             1 
                           
                           ⁢ 
                           2 
                           ⁢ 
                           4 
                           ⁢ 
                           3 
                         
                       
                       ) 
                     
                     ρ 
                   
                 
               
               
                 
                   Equation 
                   ⁢ 
                       
                   
                     ( 
                     1 
                     ) 
                   
                 
               
             
           
         
       
     
     where “E” is the energy level (MeV) of the e-beam accelerator and “ρ” is the density (g/cm 3 ) of the given material. Equation 1 is derived from a Monte Carlo simulation for one-sided irradiation through polystyrene. As such, the computed penetration depth is an approximate value for polymeric and higher density materials. Based on the foregoing equation, Table 1 lists various materials that may be candidate materials for the shields  3828   a,b , their respective densities in g/cc, and their calculated penetration depth Rp at energy levels E of 1 MeV, 2 MeV, and 5 MeV: 
     
       
         
           
               
               
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                   
                   
                 Penetration Depth (mm) 
               
            
           
           
               
               
               
               
               
            
               
                 Element 
                 Density (g/cc) 
                 1 MeV 
                 2 MeV 
                 5 MeV 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Carbon 
                 2.3 
                 1.69 
                 3.94 
                 10.67 
               
               
                 Aluminum 
                 2.7 
                 1.42 
                 3.30 
                 8.93 
               
               
                 Iron 
                 7.9 
                 0.49 
                 1.13 
                 3.06 
               
               
                 Stainless Steel 
                 8.1 
                 0.47 
                 1.10 
                 2.99 
               
               
                 Copper 
                 8.9 
                 0.43 
                 1.00 
                 2.71 
               
               
                 Lead 
                 11.4 
                 0.34 
                 0.78 
                 2.12 
               
               
                 Tantalum 
                 16.7 
                 0.23 
                 0.53 
                 1.45 
               
               
                 Tungsten 
                 19.4 
                 0.20 
                 0.46 
                 1.25 
               
               
                 Osmium 
                 22.6 
                 0.17 
                 0.39 
                 1.07 
               
               
                   
               
            
           
         
       
     
     As indicated in Table 1, the higher the density of the material, the lower the penetration depth and, consequently, the thinner the material can be to adequately shield sensitive electronic components at lower energy levels. Moreover, the thinner the shield material, the thinner the product (e.g., the sensor control device  3702 ) can be. 
     According to one or more embodiments of the present disclosure, the shields  3828   a,b  that protect the data processing unit  3808  from radiation exposure may be any non-magnetic metal with a density of at least 2.0 g/cc. In other embodiments, the shields  3828   a,b  may be a non-magnetic metal with a density of at least 5.0 g/cc. According to Table 1, suitable materials for the shields  3828   a,b  can include, but are not limited to, iron, stainless steel, copper, lead, tantalum, tungsten, and osmium. Because of its low cost and availability, stainless steel may be a preferred material. In some embodiments, the material for the shields  3828   a,b  may be any non-magnetic metal with a density ranging between about 2.0 g/cc and about 23.0 g/cc. In other embodiments, the material for the shields  3828   a,b  may be a non-magnetic metal with a density ranging between about 5.0 g/cc and about 15.0 g/cc. 
     In other embodiments, the shields  3828   a,b  that protect the data processing unit  3808  from radiation exposure may be a metal-filled thermoplastic polymer where the shielding metal exhibits a density of at least 2.0 g/cc. In such embodiments, the metal-filled thermoplastic polymer may be, but not limited to, polyamide, polycarbonate, or polystyrene. In such embodiments, the shields  3828   a,b  may be fabricated by mixing the shielding material (metal) in an adhesive matrix and dispensing the combination onto shaped components or otherwise directly onto the data processing unit  3808 . Moreover, in such embodiments, the shield(s)  3828   a,b  may comprise an enclosure that encapsulates (or substantially encapsulates) the data processing unit  3808 . 
       FIG.  43    is a cross-sectional view of the sensor control device  3702  mounted within the sensor applicator  102  with the applicator cap  210  secured thereto, according to one or more additional embodiments. Similar to the embodiments of  FIGS.  41 A- 41 B , one or more shields may be used to protect sensitive electronic components of the sensor control device  3702 . Unlike the embodiments of  FIGS.  41 A- 41 B , however, the shields of  FIG.  43    are magnetic shields configured to divert propagating radiation from the radiation sterilization  4004  ( FIGS.  40 B and  41 A- 41 B ) away from or otherwise around the data processing unit  3808 . 
     More specifically, it is possible to locally deflect an electron beam away from a component of interest, such as the data processing unit  3808 , by generating a static magnetic field. Charged particles experience a force when travelling through a magnetic field, and the direction of this force is perpendicular to the direction of the field and the velocity of the charge. In equation form, a particle with mass m and charge q moving with velocity v in a magnetic field B experiences a force characterized by the following equation: 
         F=qv×B   Equation (2)
 
     This is a vector equation which indicates that the magnitude of the force F is: 
         F =( qvB )sin θ  Equation (3)
 
     where θ is the angle between the velocity v and the magnetic field B, and the direction of the force is perpendicular to both the velocity v and the magnetic field B (in a sense given by the right hand rule). An electron (charge −e) injected into a uniform magnetic field B and moving perpendicular to the field B experiences a force: 
         F=−evB   Equation (4)
 
     Now the force F remains perpendicular to the velocity v and the electron moves in a circular path of radius R. The radial (centripetal) acceleration is then: 
     
       
         
           
             
               
                 
                   a 
                   = 
                   
                     - 
                     
                       
                         v 
                         2 
                       
                       R 
                     
                   
                 
               
               
                 
                   Equation 
                   ⁢ 
                        
                   
                     ( 
                     5 
                     ) 
                   
                 
               
             
           
         
       
     
     Now apply Newton&#39;s second law of motion: 
     
       
         
           
             
               
                 
                   F 
                   = 
                   ma 
                 
               
               
                 
                   Equation 
                   ⁢ 
                       
                   
                     ( 
                     6 
                     ) 
                   
                 
               
             
           
         
       
       
         
           
             
               
                 
                   evB 
                   = 
                   
                     m 
                     ⁢ 
                     
                       
                         v 
                         2 
                       
                       R 
                     
                   
                 
               
               
                 
                   Equation 
                   ⁢ 
                       
                   
                     ( 
                     7 
                     ) 
                   
                 
               
             
           
         
       
     
     Thus, the radius R of the electron&#39;s path is: 
     
       
         
           
             
               
                 
                   R 
                   = 
                   
                     
                       m 
                       ⁢ 
                       v 
                     
                     
                       e 
                       ⁢ 
                       B 
                     
                   
                 
               
               
                 
                   Equation 
                   ⁢ 
                        
                   
                     ( 
                     8 
                     ) 
                   
                 
               
             
           
         
       
     
     Accordingly, an electron having a mass m with a charge e and traveling at a velocity v through a magnetic field B, perpendicular to the direction of the velocity v, will be deflected in a circle of radius R and at a tangent to this circle once outside the influence of the magnetic field B. The magnetic field may be placed (generated) anywhere along the path of the propagating radiation (e.g., the e-beam) before it can strike the component of interest (e.g., the data processing unit  3808 ). 
     In one embodiment, a first magnet  4302   a  may be arranged within the electronics housing  3704  adjacent the data processing unit  3808  to generate a static magnetic field. In the illustrated embodiment, the first magnet  4302   a  is arranged where the second shield  3828   b  of  FIGS.  41 A- 41 B  was placed. In such embodiments, a propagating radiation beam  4304  (e.g., e-beam) may pass through the first magnet  4302   a  and the static magnetic field generated by the first magnet  4302   a  will cause the radiation beam  4304  to be diverted away from the data processing unit  3808 . 
     In another embodiment, or in addition thereto, a second magnet  4302   b  may be arranged within the applicator cap  210  to generate a static magnetic field. In the illustrated embodiment, the second magnet  4302   b  is positioned to interpose the radiation source (e.g., an e-beam accelerator) and the data processing unit  3808 . A propagating radiation beam  4306  (e.g., e-beam) may pass through the second magnet  4302   b  and the static magnetic field generated by the second magnet  4302   b  will cause the radiation beam  4306  to be diverted away from the data processing unit  3808 . 
     In yet other embodiments, or in addition thereto, a third magnet  4302   c  may be arranged external to the applicator cap  210  and the sensor applicator  102  to generate a static magnetic field. In the illustrated embodiment, the third magnet  4302   c  is positioned outside of the applicator cap  210  and otherwise interposes the radiation source (e.g., an e-beam accelerator) and the data processing unit  3808 . A propagating radiation beam  4308  (e.g., e-beam) may pass through the third magnet  4302   c  and the static magnetic field generated by the third magnet  4302   c  will cause the radiation beam  4308  to be diverted away from the data processing unit  3808 . 
     As will be appreciated, precise alignment of the magnets  4302   a - c  relative to sensor control device  3702  would need to be taken into consideration and sufficient margin be applied to the location and field strength accordingly. 
     Embodiments disclosed herein include: 
     Q. A sensor control device that includes an electronics housing, a printed circuit board positioned within the electronics housing and having a data processing unit mounted thereto, a sensor extending from a bottom of the electronics housing, a sharp module removably coupled to the electronics housing and having a sharp that extends through the electronics housing and receives a portion of the sensor extending from the bottom of the electronics housing, and at least one shield positioned within the electronics housing to protect the data processing unit from radiation from a radiation sterilization process. 
     R. An analyte monitoring system that includes a sensor applicator, a sensor control device positioned within the sensor applicator and including an electronics housing, a printed circuit board positioned within the electronics housing and having a data processing unit mounted thereto, a sensor extending from a bottom of the electronics housing, a sharp module removably coupled to the electronics housing and having a sharp that extends through the electronics housing and receives a portion of the sensor extending from the bottom of the electronics housing, and at least one shield positioned within the electronics housing to protect the data processing unit from radiation from a radiation sterilization process. The analyte monitoring system further including a cap coupled to the sensor applicator to provide a barrier that seals the sensor control device within the sensor applicator. 
     S. A method of preparing an analyte monitoring system including loading a sensor control device into a sensor applicator, the sensor control device including an electronics housing, a printed circuit board positioned within the electronics housing and having a data processing unit mounted thereto, a sensor extending from a bottom of the electronics housing, a sharp module removably coupled to the electronics housing and having a sharp that extends through the electronics housing and receives a portion of the sensor extending from the bottom of the electronics housing, and at least one shield positioned within the electronics housing. The method further including securing a cap to the sensor applicator and thereby providing a barrier that seals the sensor control device within the sensor applicator, sterilizing the sensor and the sharp with radiation sterilization while the sensor control device is positioned within the sensor applicator, and shielding the data processing unit with the at least one shield from radiation from the radiation sterilization. 
     T. A sensor control device that includes an electronics housing having a shell matable with a mount, a printed circuit board positioned within the electronics housing and defining a battery aperture sized to receive a battery, an axial battery contact extending into the battery aperture to provide electrical communication, and a radial battery contact extending into the battery aperture to provide electrical communication. 
     Each of embodiments Q, R, S, and T may have one or more of the following additional elements in any combination: Element 1: further comprising a battery aperture defined in the printed circuit board, a battery received within the battery aperture, an axial battery contact coupled to the printed circuit board and extending into the battery aperture to facilitate electrical communication, and a radial battery contact coupled to the printed circuit board and extending into the battery aperture to facilitate electrical communication. Element 2: further comprising one or more sensor contacts arranged on a flag of the sensor, and one or more circuitry contacts provided on the printed circuit board and engageable with the one or more sensor contacts to facilitate direct connection between the sensor and the printed circuit board. Element 3: wherein the at least one shield interposes the data processing unit and a radiation source that facilitates radiation sterilization. Element 4: wherein the at least one shield comprises a first shield facing a bottom of the printed circuit board and a second shield facing a top of the printed circuit board, and wherein the data processing unit interposes the first and second shields. Element 5: wherein the at least one shield comprises an enclosure that encapsulates the data processing unit. Element 6: wherein the at least one shield is made of a non-magnetic metal that exhibits a density ranging between about 2 g/cc and about 23 g/cc. Element 7: wherein the at least one shield is made of thermoplastic polymer mixed with a non-magnetic metal having a density of at least 2.0 g/cc. Element 8: further comprising a plurality of electronic modules coupled to top and bottom surfaces of the printed circuit board. Element 9: wherein the electronics housing comprises a mount and the shell secured together and sealed with an adhesive. Element 10: wherein the at least one shield comprises a magnet arranged to divert the radiation away from the data processing unit. 
     Element 11: wherein the at least one shield interposes the data processing unit and a radiation source that facilitates radiation sterilization of the sensor and the sharp. Element 12: wherein the at least one shield is made with a non-magnetic metal having a density of at least 2.0 g/cc. Element 13: wherein the sensor control device is subjected to the radiation sterilization while positioned within the sensor applicator and at an energy level ranging between about 0.1 MeV and about 10.0 MeV. Element 14: wherein the at least one shield comprises a magnet arranged to divert the radiation away from the data processing unit. 
     Element 15: wherein the at least one shield interposes the data processing unit and a radiation source that facilitates the radiation sterilization, and wherein the at least one shield is made with a non-magnetic metal having a density of at least 2.0 g/cc, the method further comprising undertaking the radiation sterilization at an energy level ranging between about 0.1 MeV and about 10.0 MeV. Element 16: wherein the electronics housing comprises a shell matable with a mount, and wherein loading the sensor control device into the sensor applicator is preceded by sealing the shell to the mount with an adhesive and thereby generating a sterile barrier. Element 17: wherein the at least one shield comprises a magnet, and wherein shielding the data processing unit with the at least one shield comprises generating a static magnetic field with the magnet, and diverting the radiation away from the data processing unit with the static magnetic field. 
     Element 18: further comprising a plurality of electronic modules coupled to top and bottom surfaces of the printed circuit board. Element 19: wherein a plurality of module pockets are defined in an inner surface of the mount to accommodate the plurality of electronic modules. Element 20: wherein the mount and the shell are secured together and sealed with an adhesive. Element 21: wherein the shell defines a reference feature extending a short distance into an interior of the electronics housing. Element 22: further comprising an adhesive patch positioned on an underside of the mount. Element 23: wherein the shell defines an angled outer periphery. Element 24: further comprising a sensor partially arranged within the electronics housing and having a flag with one or more sensor contacts, and a compliant member arranged to interpose the flag and an inner surface of the shell and provide a passive biasing load against the flag to force the one or more sensor contacts into engagement with a corresponding one or more circuitry contacts provided on the printed circuit board. Element 25: wherein the compliant member comprises an elastomeric O-ring. Element 26: further comprising at least one shield positioned within the electronics housing, and a shield locator defined in an inner surface of the shell or the mount to accommodate at least a portion of the at least one shield. Element 27: wherein the at least one shield comprises a first shield and a second shield, and wherein the shield locator comprises a first shield locator defined in an inner surface of the shell to accommodate at least a portion of the first shield, and a second shield locator defined in an inner surface of the mount to accommodate at least a portion of the second shield. Element 28: further comprising one or more clocking receptacles defined on one of the mount or the shell, and one or more clocking posts defined on the other of the mount or the shell and sized to be received within the one or more clocking receptacles to properly align the shell to the mount. Element 29: wherein a battery locator is defined in an inner surface of at least one of the shell and the mount and sized to accommodate a portion of the battery. Element 30: wherein the inner surface of the at least one of the shell and the mount further defines a contact pocket adjacent the battery locator and sized to accommodate a portion of the axial contact. Element 31: further comprising a plurality of carrier grip features defined about an outer periphery of the mount and axially offset from a bottom of the mount. 
     By way of non-limiting example, exemplary combinations applicable to Q, R, S, and T include: Element 3 with Element 4; Element 12 with Element 13; Element 18 and Element 19; Element 20 and Element 21; Element 24 and Element 25; Element 26 and Element 27; and Element 28 and Element 30. 
     One-Piece Analyte Monitoring Systems with Sensor Cap 
     Referring briefly again to  FIGS.  1  and  2 A- 2 G , for the two-piece architecture system, the sensor tray  202  and the sensor applicator  102  are provided to the user as separate packages, thus requiring the user to open each package and finally assemble the system. In some applications, the discrete, sealed packages allow the sensor tray  202  and the sensor applicator  102  to be sterilized in separate sterilization processes unique to the contents of each package and otherwise incompatible with the contents of the other. More specifically, the sensor tray  202 , which includes the plug assembly  207 , including the sensor  110  and the sharp  220 , may be sterilized using radiation sterilization, such as electron beam (or “e-beam”) irradiation. Radiation sterilization, however, can damage the electrical components arranged within the electronics housing of the sensor control device  104 . Consequently, if the sensor applicator  102 , which contains the electronics housing of the sensor control device  104 , needs to be sterilized, it may be sterilized via another method, such as gaseous chemical sterilization using, for example, ethylene oxide. Gaseous chemical sterilization, however, can damage the enzymes or other chemistry and biologics included on the sensor  110 . Because of this sterilization incompatibility, the sensor tray  202  and the sensor applicator  102  are commonly sterilized in separate sterilization processes and subsequently packaged separately, which requires the user to finally assemble the components for use. 
     According to embodiments of the present disclosure, the sensor control device  104  may be modified to provide a one-piece architecture that may be subjected to sterilization techniques specifically designed for a one-piece architecture sensor control device. A one-piece architecture allows the sensor applicator  102  and the sensor control device  104  to be shipped to the user in a single, sealed package that does not require any final user assembly steps. Rather, the user need only open one package and subsequently deliver the sensor control device  104  to the target monitoring location. The one-piece system architecture described herein may prove advantageous in eliminating component parts, various fabrication process steps, and user assembly steps. As a result, packaging and waste are reduced, and the potential for user error or contamination to the system is mitigated. 
       FIG.  44    is a side view of an example sensor control device  4402 , according to one or more embodiments of the present disclosure. The sensor control device  4402  may be similar in some respects to the sensor control device  104  of  FIG.  1    and therefore may be best understood with reference thereto. Moreover, the sensor control device  4402  may replace the sensor control device  104  and, therefore, may be used in conjunction with the sensor applicator  102  of  FIG.  1   , which may deliver the sensor control device  4402  to a target monitoring location on a user&#39;s skin. 
     Unlike the sensor control device  104  of  FIG.  1   , however, the sensor control device  4402  may comprise a one-piece system architecture not requiring a user to open multiple packages and finally assemble the sensor control device  4402  prior to application. Rather, upon receipt by the user, the sensor control device  4402  may already be fully assembled and properly positioned within the sensor applicator  102  ( FIG.  1   ). To use the sensor control device  4402 , the user need only open one barrier (e.g., the applicator cap  210  of  FIG.  2 B ) before promptly delivering the sensor control device  4402  to the target monitoring location for use. 
     As illustrated, the sensor control device  4402  includes an electronics housing  4404  that is generally disc-shaped and may have a circular cross-section. In other embodiments, however, the electronics housing  4404  may exhibit other cross-sectional shapes, such as ovoid or polygonal, without departing from the scope of the disclosure. The electronics housing  4404  may be configured to house or otherwise contain various electrical components used to operate the sensor control device  4402 . In at least one embodiment, an adhesive patch  4405  may be arranged at the bottom of the electronics housing  4404 . The adhesive patch  4405  may be similar to the adhesive patch  108  of  FIG.  1   , and may thus help adhere the sensor control device  4402  to the user&#39;s skin for use. 
     The electronics housing  4404  may include a shell  4406  and a mount  4408  that is matable with the shell  4406 . The shell  4406  may be secured to the mount  4408  via a variety of ways, such as a snap fit engagement, an interference fit, sonic welding, one or more mechanical fasteners (e.g., screws), a gasket, an adhesive, or any combination thereof. In some cases, the shell  4406  may be secured to the mount  4408  such that a sealed interface therebetween is generated. In such embodiments, a seal member  4409 , such as a gasket or an adhesive, may be positioned at or near the outer diameter (periphery) of the shell  4406  and the mount  4408 , and securing the two components together may compress the seal member  4409  and thereby generate a sealed interface. The seal member  4409  secures the shell  4406  to the mount  4408  and provides structural integrity, but may also isolate the interior of the electronics housing  4404  from outside contamination. If the sensor control device  4402  is assembled in a controlled environment, there may be no need to terminally sterilize the internal electrical components. Rather, the sealed interface may provide a sufficient sterile barrier for the assembled electronics housing  4404 . 
     The sensor control device  4402  may further include a sensor  4410  (partially visible) and a sharp  4412  (partially visible) used to help deliver the sensor  4410  transcutaneously under a user&#39;s skin during application of the sensor control device  4402 . As illustrated, corresponding portions of the sensor  4410  and the sharp  4412  extend distally from the electronics housing  4404  and, more particularly, from the bottom of the mount  4408 . The sharp  4412  may include a sharp hub  4414  configured to secure and carry the sharp  4412 . To couple the sharp  4412  to the sensor control device  4402 , the sharp  4412  may be advanced axially through the electronics housing  4404  until the sharp hub  4414  engages an upper portion of the shell  4406 . As the sharp  4412  penetrates the electronics housing  4404 , the exposed portion of the sensor  4410  may be received within a hollow or recessed (arcuate) portion of the sharp  4412 . The remaining portion of the sensor  4410  is arranged within the interior of the electronics housing  4404 . 
     The sensor control device  4402  may further include a sensor cap  4416 , as shown exploded (detached). The sensor cap  4416  may be removably coupled to the sensor control device  4402  (e.g., the electronics housing  4404 ) at or near the bottom of the mount  4408 . As illustrated, the sensor cap  4416  may comprise a generally cylindrical and elongate body having a first end  4418   a  and a second end  4418   b  opposite the first end  4418   a . The first end  4418   a  may be open to provide access into an inner chamber  4420  defined within the body. In contrast, the second end  4418   b  may be closed and may provide or otherwise define an engagement feature  4422 . As described herein, the engagement feature  4422  may be configured to help the sensor cap  4416  mate with the cap (e.g., the applicator cap  210  of  FIG.  2 B ) of a sensor applicator (e.g., the sensor applicator  102  of  FIGS.  1  and  2 A- 2 G ) such that the sensor cap  4416  is removed from the sensor control device  4402  upon removing the cap from the sensor applicator. While the engagement feature  4422  is shown at or near the second end  4418   b  of the sensor cap  4416 , the engagement feature  4422  may alternatively be positioned at an intermediate location between the first and second ends  4418   a,b.    
     As discussed in more detail below, the sensor cap  4416  may provide a sealed barrier surrounding and protecting the exposed portions of the sensor  4410  and the sharp  4412  from gaseous chemical sterilization. The sensor cap  4416  helps form a sealed sub-assembly that can first be sterilized using radiation sterilization, following which components of the sensor control device  4402  that are sensitive to radiation sterilization may be assembled to the sealed subassembly and then subjected to gaseous chemical sterilization. 
       FIG.  45    is an exploded view of the sensor control device  4402 , according to one or more embodiments. The shell  4406  and the mount  4408  operate as opposing clamshell halves that enclose or otherwise substantially encapsulate the various electronic components of the sensor control device  4402 . The adhesive patch  4405  may be applied to a bottom  4501  of the mount  4408 . 
     As illustrated, the shell  4406  may provide or otherwise define a sharp and sensor locator  4502  and a clocking receptacle  4504 . The sharp and sensor locator  4502  may be configured to receive portions of both the sharp  4412  and the sensor  4410 . Moreover, the sharp and sensor locator  4502  may be configured to align with and be partially received within a central aperture  4506  defined in the mount  4408 . Similarly, the clocking receptacle  4504  may be configured to align with and be received within a clocking post (not shown) defined on the inner surface of the mount  4408 . Mating the sharp and sensor locator  4502  with the central aperture  4506 , and simultaneously mating the clocking receptacle  4504  with the clocking post may help axially and rotationally align the shell  4406  with the mount  4408 . 
     In some embodiments, a first seal member  4508   a  (i.e., the seal member  4409  of  FIG.  44   ) may be applied to one or both of the shell  4406  and the mount  4408  to secure the two components together. As illustrated, the first seal member  4508   a  may be applied around the outer diameter (periphery) of the shell  4406 , the mount  4408 , or both. In another embodiment, or in addition thereto, a second seal member  4508   b  may be used to seal the interface between the sharp and sensor locator  4502  and the central aperture  4506 . More specifically, the second seal member  4508   b  may be configured to provide a sealed interface at an annular ridge  4510  that circumscribes the sharp and sensor locator  4502 . When the shell  4406  and the mount  4408  are mated, the annular ridge  4510  may juxtapose an opposing surface defined on the bottom of the mount  4408 , and the seal member  4508   b  may facilitate a seal between the opposing structures. The seal members  4508   a,b  may comprise, for example, an adhesive or a gasket, and each may help secure the shell  4406  to the mount  4408  and seal the interface between the two components, and thereby isolate the interior of the electronics housing  4404  ( FIG.  44   ) from outside contamination. 
     The sensor control device  4402  may include a printed circuit board (PCB)  4516  that may be arranged within the interior cavity formed by mating the shell  4406  and the mount  4408 . A data processing unit  4518  and a battery  4520  may be mounted to or otherwise interact with the PCB  4516 . The data processing unit  4518  may comprise, for example, an application specific integrated circuit (ASIC) configured to implement one or more functions or routines associated with operation of the sensor control device  4402 . More specifically, the data processing unit  4518  may be configured to perform data processing functions, where such functions may include, but are not limited to, filtering and encoding of data signals, each of which corresponds to a sampled analyte level of the user. The data processing unit  4518  may also include or otherwise communicate with an antenna for communicating with the reader device  106  ( FIG.  1   ). 
     The battery  4520  may provide power to the sensor control device  4402  and, more particularly, to the electronic components of the PCB  4516 . While not shown in  FIG.  45   , other electronic modules or components may be mounted to the PCB  4516  and may include, but are not limited to, one or more resistors, transistors, capacitors, inductors, diodes, and switches. 
     The sensor control device  4402  may provide or otherwise include a sealed subassembly  4522  (outlined in dashed lines), which includes (among other component parts) the shell  4406 , the sensor  4410 , the sharp  4412 , and the sensor cap  4416 . As discussed in more detail below, the sealed subassembly  4522  may help isolate the sensor  4410  and the sharp  4412  within the inner chamber  4420  of the sensor cap  4416  during a gaseous chemical sterilization process, which might otherwise adversely affect the chemistry provided on the sensor  4410 . 
     As illustrated, the sensor  4410  may include a tail  4524 , a flag  4526 , and a neck  4528  that interconnects the tail  4524  and the flag  4526 . The tail  4524  may be configured to extend through the central aperture  4506  of the mount  4408  to be transcutaneously received beneath a user&#39;s skin. Moreover, the tail  4524  may have an enzyme or other chemistry included thereon to help facilitate analyte monitoring. The flag  4526  may include a generally planar surface having one or more sensor contacts  4530  (three shown) configured to align with and engage a corresponding one or more circuitry contacts (not shown) provided on the PCB  4516 . In some embodiments, the sensor contacts  4530  may comprise a carbon impregnated polymer printed or otherwise digitally applied to the flag  4526 . 
     In assembling the sealed subassembly, the flag  4526  may be received at the clocking receptacle  4504  and the tail  4524  may be received within the sharp and sensor locator  4502 . In some embodiments, a groove  4532  may be defined in the annular ridge  4510  to receive and seat the neck  4528 , and may allow the neck  4528  to be sealed below and on top and thereby isolate the enzymes and other chemistry included on the tail  4524 . 
     The sensor control device  4402  may further include a compliant member  4534  receivable by the clocking receptacle  4504  and arranged to interpose the flag  4526  and the inner surface of the shell  4406 . The compliant member  4534  may be configured to provide a passive biasing load against the flag  4526  that forces the sensor contacts  4530  into continuous engagement with the corresponding circuitry contacts on the PCB  4516 . In the illustrated embodiment, the compliant member  4534  is an elastomeric O-ring, but could alternatively comprise any other type of biasing device or mechanism, such as a compression spring or the like. In other embodiments, however, the compliant member  4534  may form an integral part of the shell  4406 , such as being an overmolded or co-molded portion of the shell  4406 . 
     The sharp  4412  may include a sharp tip  4536  extendable through the coaxially aligned sharp and sensor locator  4502  and the central aperture  4506  of the shell  4406  and the mount  4408 , respectively. In some embodiments, as the sharp tip  4536  extends through the sensor control device  4402 , the tail  4524  of the sensor  4410  may be received within a hollow or recessed portion of the sharp tip  4536 . The sharp tip  4536  may be configured to penetrate the skin while carrying the tail  4524  to put the active chemistry of the tail  4524  into contact with bodily fluids. The sharp tip  4536  may be advanced through the sensor control device  4402  until the sharp hub  4414  engages an upper surface of the shell  4406 . In some embodiments, the sharp hub  4414  may form a sealed interface at the upper surface of the shell  4406 . 
     In the illustrated embodiment, the sealed subassembly  4522  may further include a collar  4540  that provides or otherwise defines a column  4542  and an annular shoulder  4544  extending radially outward from the column  4542 . In assembling the sealed subassembly  4522 , at least a portion of the column  4542  may be received within the inner chamber  4420  of the sensor cap  4416  at the first end  4418   a . The sensor cap  4416  may be removably coupled to the collar  4540  and separated from the collar  4540  prior to delivering the sensor control device  4402  to the target monitoring location on the user&#39;s skin. In some embodiments, the sensor cap  4416  may be removably coupled to the collar  4540  via an interference or friction fit. In other embodiments, the sensor cap  4416  may be threaded to the column  4542 . In yet other embodiments, the sensor cap  4416  may be removably coupled to the collar  4540  with a frangible member (e.g., a shear ring) or substance that may be broken with minimal separation force (e.g., axial or rotational force). In such embodiments, for example, the sensor cap  4416  may be secured to the collar  4540  with a tag (spot) of glue or a dab of wax. 
     In some embodiments, a third seal member  4508   c  may interpose the annular shoulder  4544  and the annular ridge  4510  to form a sealed interface. In such embodiments, the third seal member  4508   c  may also extend (flow) into the groove  4532  defined in the annular ridge  4510  and thereby seal about the neck  4528  of the sensor  4410 . Similar to the first and second seal members  4508   a,b , the third seal member  4508   c  may comprise an adhesive or a gasket. 
     In some embodiments, however, the collar  4540  may be omitted from the sealed subassembly  4522  and the sensor cap  4416  may alternatively be removably coupled to the sharp and sensor locator  4502 . In such embodiments, the sensor cap  4416  may be removably coupled to the sharp and sensor locator  4502  via an interference or friction fit, threading, with a frangible member or substance, or any combination thereof. 
       FIG.  46 A  is a cross-sectional side view of the assembled sealed subassembly  4522  of  FIG.  45   , according to one or more embodiments. To assemble the sealed subassembly  4522 , the compliant member  4534  may first be received about the clocking receptacle  4504  and the flag  4526  of the sensor  4410  may subsequently be placed atop the compliant member  4534  and also about the clocking receptacle  4504 . Alternatively, the compliant member  4534  may form part of the shell  4406  (e.g., co-molded, overmolded, etc.) at the clocking receptacle  4504 , and the flag  4526  may be arranged thereon. The tail  4524  of the sensor  4410  may be received within the sharp and sensor locator  4502 , and the neck  4528  may be seated within the groove  4532  defined in the annular ridge  4510 . 
     The collar  4540  may then be extended over the sharp and sensor locator  4502  until the annular shoulder  4544  rests against the annular ridge  4510 . In some embodiments, the third seal member  4508   c  may interpose the annular shoulder  4544  and the annular ridge  4510  to form a sealed interface, and the third seal member  4508   c  may also extend (flow) into the groove  4532  to form a seal about the neck  4528 . The sensor cap  4416  may then be removably coupled to the collar  4540 , as generally described above, such that portions of one or both of the collar  4540  and the sharp and sensor locator  4502  are received within the inner chamber  4420 . In some embodiments, however, the collar  4540  may be omitted and the sensor cap  4416  may instead be received on the sharp and sensor locator  4502  and the third seal member  4508   c  may seal the interface(s) between the sensor cap  4416  and the sharp and sensor locator  4502 . 
     Before or after assembling the sensor cap  4416 , the sharp  4412  may be coupled to the sensor control device  4402  by extending the sharp tip  4536  through an aperture  4602  defined in the top of the shell  4406  and advancing the sharp  4412  through the sharp and sensor locator  4502  until the sharp hub  4414  engages a top surface of the shell  4406 . In the illustrated embodiment, the top surface where the sharp hub  4414  engages the shell  4406  comprises a recessed portion of the shell  4406 , but could alternatively comprise an upper surface that is level with adjacent portions of the shell  4406 . 
     The inner chamber  4420  may be sized and otherwise configured to receive the tail  4524  and the sharp tip  4536 . Moreover, the inner chamber  4420  may be sealed to isolate the sensor  4410  from substances that might adversely interact with the chemistry of the tail  4524 . More specifically, the inner chamber  4420  may be sealed at the interface between the hub  4414  and the shell  4406 , at the interface between the annular shoulder  4544  and the annular ridge  4510  (e.g., with the third seal member  4508   c ), and at the interface between the sensor cap  4416  and the collar  4540  (e.g., via an interference fit or the like). In some embodiments, a desiccant  4603  may be present within the inner chamber  4420  to maintain preferred humidity levels. 
     Once properly assembled, the sealed subassembly  4522  may be subjected to radiation sterilization to properly sterilize the sensor  4410  and the sharp  4412 . Advantageously, this sterilization step may be undertaken apart from the other component parts of the sensor control device  4402  ( FIG.  45   ) since radiation sterilization can damage sensitive electrical components associated with the PCB  4516  ( FIG.  45   ), such as the data processing unit  4518  ( FIG.  45   ). 
     Suitable radiation sterilization processes include, but are not limited to, electron beam (e-beam) irradiation, gamma ray irradiation, X-ray irradiation, or any combination thereof. In some embodiments, the sealed subassembly  4522  may be subjected to radiation sterilization prior to coupling the sensor cap  4416  to the collar  4540  (or the sharp and sensor locator  4502 ). In other embodiments, however, the sealed subassembly  4522  may be sterilized after coupling the sensor cap  4416  to the collar  4540  (or the sharp and sensor locator  4502 ). In such embodiments, the body of the sensor cap  4416  may comprise a material that permits propagation of radiation therethrough to facilitate radiation sterilization of the distal portions of the sensor  4410  and the sharp  4412 . Suitable materials include, but are not limited to, a non-magnetic metal (e.g., aluminum, copper, gold, silver, etc.), a thermoplastic, ceramic, rubber (e.g., ebonite), a composite material (e.g., fiberglass, carbon fiber reinforced polymer, etc.), an epoxy, or any combination thereof. In some embodiments, the sensor cap  4416  may be transparent or translucent, but can otherwise be opaque, without departing from the scope of the disclosure. 
       FIG.  46 B  is a cross-sectional side view of the fully assembled sensor control device  4402 , according to one or more embodiments. Once assembled and properly sterilized, as discussed above, the sealed subassembly  4522  of  FIG.  46 A  may be assembled to the remaining component parts of the sensor control device  4402 . The PCB  4516  may be positioned within the shell  4406 , and the mount  4408  may subsequently be secured to the shell  4406 . To axially and rotationally align the shell  4406  with the mount  4408 , the sensor cap  4416  may be aligned with and extended through the central aperture  4506  of the mount  4408 . The sharp and sensor locator  4502  may then be received within the central aperture  4506 , and the clocking receptacle  4504  may be mated with a clocking post  4604  defined by the mount  4408 . 
     As discussed above, the first and second seal members  4508   a,b  may be used to secure the mount  4408  to the shell  4406  and also isolate the interior of the electronics housing  4404  from outside contamination. In the illustrated embodiment, the second seal member  4508   b  may interpose the annular shoulder  4544  of the collar  4540  and a portion of the mount  4408  and, more particularly, the central aperture  4506 . The adhesive patch  4405  may then be applied to the bottom  4501  of the mount  4408 . 
       FIGS.  47 A and  47 B  are side and cross-sectional side views, respectively, of an example embodiment of the sensor applicator  102  with the applicator cap  210  coupled thereto. More specifically,  FIG.  47 A  depicts how the sensor applicator  102  might be shipped to and received by a user, and  FIG.  47 B  depicts the sensor control device  4402  arranged within the sensor applicator  102 . Accordingly, the fully assembled sensor control device  4402  may already be assembled and installed within the sensor applicator  102  prior to being delivered to the user, thus removing any additional assembly steps that a user would otherwise have to perform. 
     The fully assembled sensor control device  4402  may be loaded into the sensor applicator  102 , and the applicator cap  210  may subsequently be coupled to the sensor applicator  102 . In some embodiments, the applicator cap  210  may be threaded to the housing  208  and include a tamper ring  4702 . Upon rotating (e.g., unscrewing) the applicator cap  210  relative to the housing  208 , the tamper ring  4702  may shear and thereby free the applicator cap  210  from the sensor applicator  102 . 
     According to the present disclosure, while loaded in the sensor applicator  102 , the sensor control device  4402  may be subjected to gaseous chemical sterilization  4704  configured to sterilize the electronics housing  4404  and any other exposed portions of the sensor control device  4402 . To accomplish this, a chemical may be injected into a sterilization chamber  4706  cooperatively defined by the sensor applicator  102  and the interconnected cap  210 . In some applications, the chemical may be injected into the sterilization chamber  4706  via one or more vents  4708  defined in the applicator cap  210  at its proximal end  610 . Example chemicals that may be used for the gaseous chemical sterilization  4704  include, but are not limited to, ethylene oxide, vaporized hydrogen peroxide, nitrogen oxide (e.g., nitrous oxide, nitrogen dioxide, etc.), and steam. 
     Since the distal portions of the sensor  4410  and the sharp  4412  are sealed within the sensor cap  4416 , the chemicals used during the gaseous chemical sterilization process do not interact with the enzymes, chemistry, and biologics provided on the tail  4524  and other sensor components, such as membrane coatings that regulate analyte influx. 
     Once a desired sterility assurance level has been achieved within the sterilization chamber  4706 , the gaseous solution may be removed and the sterilization chamber  4706  may be aerated. Aeration may be achieved by a series of vacuums and subsequently circulating a gas (e.g., nitrogen) or filtered air through the sterilization chamber  4706 . Once the sterilization chamber  4706  is properly aerated, the vents  4708  may be occluded with a seal  4712  (shown in dashed lines). 
     In some embodiments, the seal  4712  may comprise two or more layers of different materials. The first layer may be made of a synthetic material (e.g., a flash-spun high-density polyethylene fiber), such as Tyvek® available from DuPont®. Tyvek® is highly durable and puncture resistant and allows the permeation of vapors. The Tyvek® layer can be applied before the gaseous chemical sterilization process, and following the gaseous chemical sterilization process, a foil or other vapor and moisture resistant material layer may be sealed (e.g., heat sealed) over the Tyvek® layer to prevent the ingress of contaminants and moisture into the sterilization chamber  4706 . In other embodiments, the seal  4712  may comprise only a single protective layer applied to the applicator cap  210 . In such embodiments, the single layer may be gas permeable for the sterilization process, but may also be capable of protection against moisture and other harmful elements once the sterilization process is complete. 
     With the seal  4712  in place, the applicator cap  210  provides a barrier against outside contamination, and thereby maintains a sterile environment for the assembled sensor control device  4402  until the user removes (unthreads) the applicator cap  210 . The applicator cap  210  may also create a dust-free environment during shipping and storage that prevents the adhesive patch  4714  from becoming dirty. 
       FIG.  48    is a perspective view of an example embodiment of the applicator cap  210 , according to the present disclosure. As illustrated, the applicator cap  210  is generally circular and defines a series of threads  4802  used to couple the applicator cap  210  to the sensor applicator  102  ( FIGS.  47 A and  47 B ). The vents  4708  discussed above are also visible in the bottom of the applicator cap  210 . 
     The applicator cap  210  may further provide and otherwise define a cap post  4804  centrally located within the interior of the applicator cap  210  and extending proximally from the bottom thereof. The cap post  4804  may be configured to receive the sensor cap  4416  ( FIGS.  44 ,  45 ,  46 A- 46 B ) upon coupling the applicator cap  210  to the sensor applicator  102 . More specifically, the cap post  4804  may define a receiver feature  4806  configured to interact with (e.g., receive) the engagement feature  4422  ( FIG.  44   ) of the sensor cap  4416 . Upon removing the applicator cap  210  from the sensor applicator  102 , however, the receiver feature  4806  may retain the engagement feature  4422  and thereby prevent the sensor cap  4416  from separating from the cap post  4804 . Consequently, removing the applicator cap  210  from the sensor applicator  102  will simultaneously detach the sensor cap  4416  from the sensor control device  4402  ( FIG.  47 B ), and thereby expose the distal portions of the sensor  4410  ( FIG.  47 B ) and the sharp  4412  ( FIG.  47 B ). 
     As will be appreciated, many design variations of the engagement and receiver features  4422 ,  4806  may be employed, without departing from the scope of the disclosure. Any design may be used that allows the engagement feature  4422  to be received by the receiver feature  4806  upon coupling the applicator cap  210  to the sensor applicator  102 , and subsequently prevent the sensor cap  4416  from separating from the cap post  4804  upon removing the applicator cap  210 . In some embodiments, for example, the engagement and receiver features  4422 ,  4806  may comprise a threaded interface or a keyed mating profile that allows initial engagement but prevents subsequent disengagement. 
     In the illustrated embodiment, the receiver feature  4806  includes one or more compliant members  4808  that are expandable or flexible to receive the engagement feature  4422  ( FIG.  44   ). The engagement feature  4422  may comprise, for example, an enlarged head or define one or more radial protrusions, and the compliant member(s)  4808  may comprise a collet-type device that includes a plurality of compliant fingers configured to flex radially outward to receive the enlarged head or radial protrusion(s). In other embodiments, however, the compliant member(s)  4808  may comprise an elastomer or another type of compliant material configured to expand radially to receive the enlarged head or radial protrusion(s). 
       FIG.  49    is a cross-sectional side view of the sensor control device  4402  positioned within the applicator cap  210 , according to one or more embodiments. In the illustrated depiction, the remaining portions of the sensor applicator  102  ( FIGS.  47 A- 47 B ) are omitted for simplicity. As illustrated, the opening to the receiver feature  4806  exhibits a first diameter D 1 , while the engagement feature  4422  of the sensor cap  4416  exhibits a second diameter D 2  that is larger than the first diameter D 1  and greater than the outer diameter of the remaining portions of the sensor cap  4416 . Accordingly, as the sensor cap  4416  is extended into the cap post  4804 , the compliant member(s)  4808  may flex (expand) radially outward to receive the engagement feature  4422 . 
     In some embodiments, the engagement feature  4422  may provide or otherwise define an angled outer surface that helps bias the compliant member(s)  4808  radially outward. The engagement feature  4422 , however, may also define an upper shoulder  4902  that prevents the sensor cap  4416  from reversing out of the cap post  4804 . More specifically, the shoulder  4902  may comprise a sharp surface at the second diameter D 2  that will engage but not urge the compliant member(s)  4808  to flex radially outward in the reverse direction. 
     Once the engagement feature  4422  bypasses the receiver feature  4806 , the compliant member(s)  4808  flex back to (or towards) their natural state. Upon removing the applicator cap  210  from the sensor applicator  102  ( FIGS.  47 A- 47 B ), the shoulder  4902  will engage and bind against the compliant member(s)  4808 , thereby separating the sensor cap  4416  from the sensor control device  4402  and exposing the distal portions of the sensor  4410  and the sharp  4412 . 
     In some embodiments, the receiver feature  4806  may alternatively be threaded and the engagement feature  4422  may also be threaded and configured to threadably engage the threads of the receiver feature  4806 . The sensor cap  4416  may be received within the cap post  4804  via threaded rotation. Upon removing the applicator cap  210  from the sensor applicator  102 , the opposing threads on the engagement and receiver features  4422 ,  4806  bind and the sensor cap  4416  may be separated from the sensor control device  4402 . 
       FIGS.  50 A and  50 B  are isometric and side views, respectively, of another example sensor control device  5002 , according to one or more embodiments of the present disclosure. The sensor control device  5002  may be similar in some respects to the sensor control device  4402  of  FIG.  44    and therefore may be best understood with reference thereto. Moreover, the sensor control device  5002  may replace the sensor control device  104  of  FIG.  1    and, therefore, may be used in conjunction with the sensor applicator  102  of  FIG.  1   , which may deliver the sensor control device  5002  to a target monitoring location on a user&#39;s skin. Similar to the sensor control device  4402  of  FIG.  44   , the sensor control device  5002  may comprise a one-piece architecture. 
     As illustrated, the sensor control device  5002  includes an electronics housing  5004  that includes a shell  5006  and a mount  5008  that is matable with the shell  5006 . The shell  5006  may be secured to the mount  5008  via a variety of ways, such as a snap fit engagement, an interference fit, sonic welding, one or more mechanical fasteners (e.g., screws), a gasket, an adhesive, or any combination thereof. In some cases, the shell  5006  may be secured to the mount  5008  such that a sealed interface is generated therebetween. 
     The sensor control device  5002  may further include a sensor  5010  (partially visible) and a sharp  5012  (partially visible), similar in function to the sensor  4410  and the sharp  4412  of  FIG.  44   . Corresponding portions of the sensor  5010  and the sharp  5012  extend distally from the bottom of the electronics housing  5004  (e.g., the mount  5008 ). The sharp  5012  may include a sharp hub  5014  configured to secure and carry the sharp  5012 . As best seen in  FIG.  50 B , the sharp hub  5014  may include or otherwise define a mating member  5016 . To couple the sharp  5012  to the sensor control device  5002 , the sharp  5012  may be advanced axially through the electronics housing  5004  until the sharp hub  5014  engages an upper surface of the shell  5006  and the mating member  5016  extends distally from the bottom of the mount  5008 . As the sharp  5012  penetrates the electronics housing  5004 , the exposed portion of the sensor  5010  may be received within a hollow or recessed (arcuate) portion of the sharp  5012 . The remaining portion of the sensor  5010  is arranged within the interior of the electronics housing  5004 . 
     The sensor control device  5002  may further include a sensor cap  5018 , shown exploded or detached from the electronics housing  5004  in  FIGS.  50 A- 50 B . Similar to the sensor cap  4416  of  FIG.  44   , the sensor cap  5018  may help provide a sealed barrier that surrounds and protects the exposed portions of the sensor  5010  and the sharp  5012  from gaseous chemical sterilization. As illustrated, the sensor cap  5018  may comprise a generally cylindrical body having a first end  5020   a  and a second end  5020   b  opposite the first end  5020   a . The first end  5020   a  may be open to provide access into an inner chamber  5022  defined within the body. In contrast, the second end  5020   b  may be closed and may provide or otherwise define an engagement feature  5024 . Similar to the engagement feature  4422  of  FIG.  44   , the engagement feature  5024  may help mate the sensor cap  5018  to the cap (e.g., the applicator cap  210  of  FIG.  2 B ) of a sensor applicator (e.g., the sensor applicator  102  of  FIGS.  1  and  2 A- 2 G ), and may help remove the sensor cap  5018  from the sensor control device  5002  upon removing the cap from the sensor applicator. 
     The sensor cap  5018  may be removably coupled to the electronics housing  5004  at or near the bottom of the mount  5008 . More specifically, the sensor cap  5018  may be removably coupled to the mating member  5016 , which extends distally from the bottom of the mount  5008 . In at least one embodiment, for example, the mating member  5016  may define a set of external threads  5026   a  ( FIG.  50 B ) matable with a set of internal threads  5026   b  ( FIG.  50 A ) defined by the sensor cap  5018 . In some embodiments, the external and internal threads  5026   a,b  may comprise a flat thread design (e.g., lack of helical curvature), which may prove advantageous in molding the parts. Alternatively, the external and internal threads  5026   a,b  may comprise a helical threaded engagement. Accordingly, the sensor cap  5018  may be threadably coupled to the sensor control device  5002  at the mating member  5016  of the sharp hub  5014 . In other embodiments, the sensor cap  5018  may be removably coupled to the mating member  5016  via other types of engagements including, but not limited to, an interference or friction fit, or a frangible member or substance that may be broken with minimal separation force (e.g., axial or rotational force). 
     In some embodiments, the sensor cap  5018  may comprise a monolithic (singular) structure extending between the first and second ends  5020   a,b . In other embodiments, however, the sensor cap  5018  may comprise two or more component parts. In the illustrated embodiment, for example, the sensor cap  5018  may include a seal ring  5028  positioned at the first end  5020   a  and a desiccant cap  5030  arranged at the second end  5020   b . The seal ring  5028  may be configured to help seal the inner chamber  5022 , as described in more detail below. In at least one embodiment, the seal ring  5028  may comprise an elastomeric O-ring. The desiccant cap  5030  may house or comprise a desiccant to help maintain preferred humidity levels within the inner chamber  5022 . The desiccant cap  5030  may also define or otherwise provide the engagement feature  5024  of the sensor cap  5018 . 
       FIGS.  51 A and  51 B  are exploded isometric top and bottom views, respectively, of the sensor control device  5002 , according to one or more embodiments. The shell  5006  and the mount  5008  operate as opposing clamshell halves that enclose or otherwise substantially encapsulate various electronic components of the sensor control device  5002 . The electronic components housed within the electronics housing  5004  may be similar to the electronic components described with reference to  FIG.  45    and, therefore, will not be described again. While not shown, the sensor control device  5002  may also include an adhesive patch that may be applied to the bottom  5102  ( FIG.  51 B ) of the mount  5008 , and may help adhere the sensor control device  5002  to the user&#39;s skin for use. 
     The sensor control device  5002  may provide or otherwise include a sealed subassembly that includes, among other component parts, the shell  5006 , the sensor  5010 , the sharp  5012 , and the sensor cap  5018 . Similar to the sealed subassembly  4522  of  FIG.  45   , the sealed subassembly of the sensor control device  5002  may help isolate the sensor  5010  and the sharp  5012  within the inner chamber  5022  ( FIG.  51 A ) of the sensor cap  5018  during a gaseous chemical sterilization process, which might otherwise adversely affect the chemistry provided on the sensor  5010 . 
     The sensor  5010  may include a tail  5104  that extends out an aperture  5106  ( FIG.  51 B ) defined in the mount  5008  to be transcutaneously received beneath a user&#39;s skin. The tail  5104  may have an enzyme or other chemistry included thereon to help facilitate analyte monitoring. The sharp  5012  may include a sharp tip  5108  extendable through an aperture  5110  ( FIG.  51 A ) defined by the shell  5006 , and the aperture  5110  may be coaxially aligned with the aperture  5106  of the mount  5008 . As the sharp tip  5108  penetrates the electronics housing  5004 , the tail  5104  of the sensor  5010  may be received within a hollow or recessed portion of the sharp tip  5108 . The sharp tip  5108  may be configured to penetrate the skin while carrying the tail  5104  to put the active chemistry of the tail  5104  into contact with bodily fluids. 
     The sharp tip  5108  may be advanced through the electronics housing  5004  until the sharp hub  5014  engages an upper surface of the shell  5006  and the mating member  5016  extends out the aperture  5106  in the bottom  5102  of the mount  5008 . In some embodiments, a seal member (not shown), such as an O-ring or seal ring, may interpose the sharp hub  5014  and the upper surface of the shell  5006  to help seal the interface between the two components. In some embodiments, the seal member may comprise a separate component part, but may alternatively form an integral part of the shell  5006 , such as being a co-molded or overmolded component part. 
     The sealed subassembly may further include a collar  5112  that is positioned within the electronics housing  5004  and extends at least partially into the aperture  5106 . The collar  5112  may be a generally annular structure that defines or otherwise provides an annular ridge  5114  on its top surface. In some embodiments, as illustrated, a groove  5116  may be defined in the annular ridge  5114  and may be configured to accommodate or otherwise receive a portion of the sensor  5010  extending laterally within the electronics housing  5004 . 
     In assembling the sealed subassembly, a bottom  5118  of the collar  5112  may be exposed at the aperture  5106  and may sealingly engage the first end  5020   a  of the sensor cap  5018  and, more particularly, the seal ring  5028 . In contrast, the annular ridge  5114  at the top of the collar  5112  may sealingly engage an inner surface (not shown) of the shell  5006 . In at least one embodiment, a seal member (not shown) may interpose the annular ridge  5114  and the inner surface of the shell  5006  to form a sealed interface. In such embodiments, the seal member may also extend (flow) into the groove  5116  defined in the annular ridge  5114  and thereby seal about the sensor  5010  extending laterally within the electronics housing  5004 . The seal member may comprise, for example, an adhesive, a gasket, or an ultrasonic weld, and may help isolate the enzymes and other chemistry included on the tail  5104 . 
       FIG.  52    is a cross-sectional side view of an assembled sealed subassembly  5200 , according to one or more embodiments. The sealed subassembly  5200  may form part of the sensor control device  5002  of  FIGS.  50 A- 50 B and  51 A- 51 B  and may include portions of the shell  5006 , the sensor  5010 , the sharp  5012 , the sensor cap  5018 , and the collar  5112 . The sealed subassembly  5200  may be assembled in a variety of ways. In one assembly process, the sharp  5012  may be coupled to the sensor control device  5002  by extending the sharp tip  5108  through the aperture  5110  defined in the top of the shell  5006  and advancing the sharp  5012  through the shell  5006  until the sharp hub  5014  engages the top of the shell  5006  and the mating member  196  extends distally from the shell  5006 . In some embodiments, as mentioned above, a seal member  5202  (e.g., an O-ring or seal ring) may interpose the sharp hub  5014  and the upper surface of the shell  5006  to help seal the interface between the two components. 
     The collar  5112  may then be received over (about) the mating member  5016  and advanced toward an inner surface  5204  of the shell  5006  to enable the annular ridge  5114  to engage the inner surface  5204 . A seal member  5206  may interpose the annular ridge  5114  and the inner surface  5204  and thereby form a sealed interface. The seal member  5206  may also extend (flow) into the groove  5116  ( FIGS.  51 A- 51 B ) defined in the annular ridge  5114  and thereby seal about the sensor  5010  extending laterally within the electronics housing  5004  ( FIGS.  51 A- 51 B ). In other embodiments, however, the collar  5112  may first be sealed to the inner surface  5204  of the shell  5006 , following which the sharp  5012  and the sharp hub  5014  may be extended through the aperture  5110 , as described above. 
     The sensor cap  5018  may be removably coupled to the sensor control device  5002  by threadably mating the internal threads  5026   b  of the sensor cap  5018  with the external threads  5026   a  of the mating member  5016 . Tightening (rotating) the mated engagement between the sensor cap  5018  and the mating member  5016  may urge the first end  5020   a  of the sensor cap  5018  into sealed engagement with the bottom  5118  of the collar  5112 . Moreover, tightening the mated engagement between the sensor cap  5018  and the mating member  5016  may also enhance the sealed interface between the sharp hub  5014  and the top of the shell  5006 , and between the annular ridge  5114  and the inner surface  5204  of the shell  5006 . 
     The inner chamber  5022  may be sized and otherwise configured to receive the tail  5104  and the sharp tip  5108 . Moreover, the inner chamber  5022  may be sealed to isolate the tail  5104  and the sharp tip  5108  from substances that might adversely interact with the chemistry of the tail  5104 . In some embodiments, a desiccant  5208  (shown in dashed lines) may be present within the inner chamber  5022  to maintain proper humidity levels. 
     Once properly assembled, the sealed subassembly  5200  may be subjected to any of the radiation sterilization processes mentioned herein to properly sterilize the sensor  5010  and the sharp  5012 . This sterilization step may be undertaken apart from the remaining portions of the sensor control device ( FIGS.  50 A- 50 B and  51 A- 51 B ) to prevent damage to sensitive electrical components. The sealed subassembly  5200  may be subjected to radiation sterilization prior to or after coupling the sensor cap  5018  to the sharp hub  5014 . When sterilized after coupling the sensor cap  5018  to the sharp hub  5014 , the sensor cap  5018  may be made of a material that permits the propagation of radiation therethrough. In some embodiments, the sensor cap  5018  may be transparent or translucent, but can otherwise be opaque, without departing from the scope of the disclosure. 
       FIGS.  53 A- 53 C  are progressive cross-sectional side views showing assembly of the sensor applicator  102  with the sensor control device  5002 , according to one or more embodiments. Once the sensor control device  5002  is fully assembled, it may then be loaded into the sensor applicator  102 . With reference to  FIG.  53 A , the sharp hub  5014  may include or otherwise define a hub snap pawl  5302  configured to help couple the sensor control device  5002  to the sensor applicator  102 . More specifically, the sensor control device  5002  may be advanced into the interior of the sensor applicator  102  and the hub snap pawl  5302  may be received by corresponding arms  5304  of a sharp carrier  5306  positioned within the sensor applicator  102 . 
     In  FIG.  53 B , the sensor control device  5002  is shown received by the sharp carrier  5306  and, therefore, secured within the sensor applicator  102 . Once the sensor control device  5002  is loaded into the sensor applicator  102 , the applicator cap  210  may be coupled to the sensor applicator  102 . In some embodiments, the applicator cap  210  and the housing  208  may have opposing, matable sets of threads  5308  that enable the applicator cap  210  to be screwed onto the housing  208  in a clockwise (or counter-clockwise) direction and thereby secure the applicator cap  210  to the sensor applicator  102 . 
     As illustrated, the sheath  212  is also positioned within the sensor applicator  102 , and the sensor applicator  102  may include a sheath locking mechanism  5310  configured to ensure that the sheath  212  does not prematurely collapse during a shock event. In the illustrated embodiment, the sheath locking mechanism  5310  may comprise a threaded engagement between the applicator cap  210  and the sheath  212 . More specifically, one or more internal threads  5312   a  may be defined or otherwise provided on the inner surface of the applicator cap  210 , and one or more external threads  5312   b  may be defined or otherwise provided on the sheath  212 . The internal and external threads  5312   a,b  may be configured to threadably mate as the applicator cap  210  is threaded to the sensor applicator  102  at the threads  5308 . The internal and external threads  5312   a,b  may have the same thread pitch as the threads  5308  that enable the applicator cap  210  to be screwed onto the housing  208 . 
     In  FIG.  53 C , the applicator cap  210  is shown fully threaded (coupled) to the housing  208 . As illustrated, the applicator cap  210  may further provide and otherwise define a cap post  5314  centrally located within the interior of the applicator cap  210  and extending proximally from the bottom thereof. The cap post  5314  may be configured to receive at least a portion of the sensor cap  5018  as the applicator cap  210  is screwed onto the housing  208 . 
     With the sensor control device  5002  loaded within the sensor applicator  102  and the applicator cap  210  properly secured, the sensor control device  5002  may then be subjected to a gaseous chemical sterilization configured to sterilize the electronics housing  5004  and any other exposed portions of the sensor control device  5002 . The gaseous chemical sterilization process may be similar to the gaseous chemical sterilization  4704  of  FIG.  47 B  and, therefore, will not be described again in detail. Since the distal portions of the sensor  5010  and the sharp  5012  are sealed within the sensor cap  5018 , the chemicals used during the gaseous chemical sterilization process are unable to interact with the enzymes, chemistry, and biologics provided on the tail  5104 , and other sensor components, such as membrane coatings that regulate analyte influx. 
       FIGS.  54 A and  54 B  are perspective and top views, respectively, of the cap post  5314 , according to one or more additional embodiments. In the illustrated depiction, a portion of the sensor cap  5018  is received within the cap post  5314  and, more specifically, the desiccant cap  5030  of the sensor cap  5018  is arranged within cap post  5314 . 
     As illustrated, the cap post  5314  may define a receiver feature  5402  configured to receive the engagement feature  5024  of the sensor cap  5018  upon coupling (e.g., threading) the applicator cap  210  ( FIG.  53 C ) to the sensor applicator  102  ( FIGS.  53 A- 53 C ). Upon removing the applicator cap  210  from the sensor applicator  102 , however, the receiver feature  5402  may prevent the engagement feature  914  from reversing direction and thus prevent the sensor cap  5018  from separating from the cap post  5314 . Instead, removing the applicator cap  210  from the sensor applicator  102  will simultaneously detach the sensor cap  5018  from the sensor control device  5002  ( FIGS.  50 A- 50 B and  53 A- 53 C ), and thereby expose the distal portions of the sensor  5010  ( FIGS.  53 A- 53 C ) and the sharp  5012  ( FIGS.  53 A- 53 C ). 
     Many design variations of the receiver feature  5402  may be employed, without departing from the scope of the disclosure. In the illustrated embodiment, the receiver feature  5402  includes one or more compliant members  5404  (two shown) that are expandable or flexible to receive the engagement feature  5024  ( FIGS.  50 A- 50 B ). The engagement feature  5024  may comprise, for example, an enlarged head and the compliant member(s)  5404  may comprise a collet-type device that includes a plurality of compliant fingers configured to flex radially outward to receive the enlarged head. 
     The compliant member(s)  5404  may further provide or otherwise define corresponding ramped surfaces  5406  configured to interact with one or more opposing camming surfaces  5408  provided on the outer wall of the engagement feature  5024 . The configuration and alignment of the ramped surface(s)  5406  and the opposing camming surface(s)  5408  is such that the applicator cap  210  is able to rotate relative to the sensor cap  5018  in a first direction A (e.g., clockwise), but the cap post  5314  binds against the sensor cap  5018  when the applicator cap  210  is rotated in a second direction B (e.g., counter clockwise). More particularly, as the applicator cap  210  (and thus the cap post  5314 ) rotates in the first direction A, the camming surfaces  5408  engage the ramped surfaces  5406 , which urge the compliant members  5404  to flex or otherwise deflect radially outward and results in a ratcheting effect. Rotating the applicator cap  210  (and thus the cap post  5314 ) in the second direction B, however, will drive angled surfaces  5410  of the camming surfaces  5408  into opposing angled surfaces  5412  of the ramped surfaces  5406 , which results in the sensor cap  5018  binding against the compliant member(s)  5404 . 
       FIG.  55    is a cross-sectional side view of the sensor control device  5002  positioned within the applicator cap  210 , according to one or more embodiments. As illustrated, the opening to the receiver feature  5402  exhibits a first diameter D 3 , while the engagement feature  5024  of the sensor cap  5018  exhibits a second diameter D 4  that is larger than the first diameter D 3  and greater than the outer diameter of the remaining portions of the sensor cap  5018 . As the sensor cap  5018  is extended into the cap post  5314 , the compliant member(s)  5404  of the receiver feature  5402  may flex (expand) radially outward to receive the engagement feature  5024 . In some embodiments, as illustrated, the engagement feature  5024  may provide or otherwise define an angled outer surface that helps bias the compliant member(s)  5404  radially outward. Once the engagement feature  5024  bypasses the receiver feature  5402 , the compliant member(s)  5404  are able to flex back to (or towards) their natural state and thus lock the sensor cap  5018  within the cap post  5314 . 
     As the applicator cap  210  is threaded to (screwed onto) the housing  208  ( FIGS.  53 A- 53 C ) in the first direction A, the cap post  5314  correspondingly rotates in the same direction and the sensor cap  5018  is progressively introduced into the cap post  5314 . As the cap post  5314  rotates, the ramped surfaces  5406  of the compliant members  5404  ratchet against the opposing camming surfaces  5408  of the sensor cap  5018 . This continues until the applicator cap  210  is fully threaded onto (screwed onto) the housing  208 . In some embodiments, the ratcheting action may occur over two full revolutions of the applicator cap  210  before the applicator cap  210  reaches its final position. 
     To remove the applicator cap  210 , the applicator cap  210  is rotated in the second direction B, which correspondingly rotates the cap post  5314  in the same direction and causes the camming surfaces  5408  (i.e., the angled surfaces  5410  of  FIGS.  54 A- 54 B ) to bind against the ramped surfaces  5406  (i.e., the angled surfaces  5412  of  FIGS.  54 A- 54 B ). Consequently, continued rotation of the applicator cap  210  in the second direction B causes the sensor cap  5018  to correspondingly rotate in the same direction and thereby unthread from the mating member  5016  to allow the sensor cap  5018  to detach from the sensor control device  5002 . Detaching the sensor cap  5018  from the sensor control device  5002  exposes the distal portions of the sensor  5010  and the sharp  5012 , and thus places the sensor control device  5002  in position for firing (use). 
       FIGS.  56 A and  56 B  are cross-sectional side views of the sensor applicator  102  ready to deploy the sensor control device  5002  to a target monitoring location, according to one or more embodiments. More specifically,  FIG.  56 A  depicts the sensor applicator  102  ready to deploy (fire) the sensor control device  5002 , and  FIG.  56 B  depicts the sensor applicator  102  in the process of deploying (firing) the sensor control device  5002 . As illustrated, the applicator cap  210  ( FIGS.  53 A- 53 C and  55   ) has been removed, which correspondingly detaches (removes) the sensor cap  5018  ( FIGS.  53 A- 53 C and  55    and thereby exposes the tail  5104  of the sensor  5010  and the sharp tip  5108  of the sharp  5012 , as described above. In conjunction with the sheath  212  and the sharp carrier  5306 , the sensor applicator  102  also includes a sensor carrier  5602  (alternately referred to as a “puck” carrier) that helps position and secure the sensor control device  5002  within the sensor applicator  102 . 
     Referring first to  FIG.  56 A , as illustrated, the sheath  212  includes one or more sheath arms  5604  (one shown) configured to interact with a corresponding one or more detents  5606  (one shown) defined within the interior of the housing  208 . The detent(s)  5606  are alternately referred to as “firing” detent(s). When the sensor control device  5002  is initially installed in the sensor applicator  102 , the sheath arms  5604  may be received within the detents  5606 , which places the sensor applicator  102  in firing position. In the firing position, the mating member  5016  extends distally beyond the bottom of the sensor control device  5002 . As discussed below, the process of firing the sensor applicator  102  causes the mating member  5016  to retract so that it does not contact the user&#39;s skin. 
     The sensor carrier  5602  may also include one or more carrier arms  5608  (one shown) configured to interact with a corresponding one or more grooves  5610  (one shown) defined on the sharp carrier  5306 . A spring  5612  may be arranged within a cavity defined by the sharp carrier  5306  and may passively bias the sharp carrier  5306  upward within the housing  208 . When the carrier arm(s)  5608  are properly received within the groove(s)  5610 , however, the sharp carrier  5306  is maintained in position and prevented from moving upward. The carrier arm(s)  5608  interpose the sheath  212  and the sharp carrier  5306 , and a radial shoulder  5614  defined on the sheath  212  may be sized to maintain the carrier arm(s)  5608  engaged within the groove(s)  5610  and thereby maintain the sharp carrier  5306  in position. 
     In  FIG.  56 B , the sensor applicator  102  is in the process of firing. As discussed herein with reference to  FIGS.  2 F- 2 G , this may be accomplished by advancing the sensor applicator  102  toward a target monitoring location until the sheath  212  engages the skin of the user. Continued pressure on the sensor applicator  102  against the skin may cause the sheath arm(s)  5604  to disengage from the corresponding detent(s)  5606 , which allows the sheath  212  to collapse into the housing  208 . As the sheath  212  starts to collapse, the radial shoulder  5614  eventually moves out of radial engagement with the carrier arm(s)  5608 , which allows the carrier arm(s)  5608  to disengage from the groove(s)  5610 . The passive spring force of the spring  5612  is then free to push upward on the sharp carrier  5306  and thereby force the carrier arm(s)  5608  out of engagement with the groove(s)  5610 , which allows the sharp carrier  5306  to move slightly upward within the housing  208 . In some embodiments, fewer coils may be incorporated into the design of the spring  5612  to increase the spring force necessary to overcome the engagement between carrier arm(s)  5608  and the groove(s)  5610 . In at least one embodiment, one or both of the carrier arm(s)  5608  and the groove(s)  5610  may be angled to help ease disengagement. 
     As the sharp carrier  5306  moves upward within the housing  208 , the sharp hub  5014  may correspondingly move in the same direction, which may cause partial retraction of the mating member  5016  such that it becomes flush, substantially flush, or sub-flush with the bottom of the sensor control device  5002 . As will be appreciated, this ensures that the mating member  5016  does not come into contact with the user&#39;s skin, which might otherwise adversely impact sensor insertion, cause excessive pain, or prevent the adhesive patch (not shown) positioned on the bottom of the sensor control device  5002  from properly adhering to the skin. 
       FIGS.  57 A- 57 C  are progressive cross-sectional side views showing assembly and disassembly of an alternative embodiment of the sensor applicator  102  with the sensor control device  5002 , according to one or more additional embodiments. A fully assembled sensor control device  5002  may be loaded into the sensor applicator  102  by coupling the hub snap pawl  5302  into the arms  5304  of the sharp carrier  5306  positioned within the sensor applicator  102 , as generally described above. 
     In the illustrated embodiment, the sheath arms  5604  of the sheath  212  may be configured to interact with a first detent  5702   a  and a second detent  5702   b  defined within the interior of the housing  208 . The first detent  5702   a  may alternately be referred to a “locking” detent, and the second detent  5702   b  may alternately be referred to as a “firing” detent. When the sensor control device  5002  is initially installed in the sensor applicator  102 , the sheath arms  5604  may be received within the first detent  5702   a . As discussed below, the sheath  212  may be actuated to move the sheath arms  5604  to the second detent  5702   b , which places the sensor applicator  102  in firing position. 
     In  FIG.  57 B , the applicator cap  210  is aligned with the housing  208  and advanced toward the housing  208  so that the sheath  212  is received within the applicator cap  210 . Instead of rotating the applicator cap  210  relative to the housing  208 , the threads of the applicator cap  210  may be snapped onto the corresponding threads of the housing  208  to couple the applicator cap  210  to the housing  208 . Axial cuts or slots  5703  (one shown) defined in the applicator cap  210  may allow portions of the applicator cap  210  near its threading to flex outward to be snapped into engagement with the threading of the housing  208 . As the applicator cap  210  is snapped to the housing  208 , the sensor cap  5018  may correspondingly be snapped into the cap post  5314 . 
     Similar to the embodiment of  FIGS.  53 A- 53 C , the sensor applicator  102  may include a sheath locking mechanism configured to ensure that the sheath  212  does not prematurely collapse during a shock event. In the illustrated embodiment, the sheath locking mechanism includes one or more ribs  5704  (one shown) defined near the base of the sheath  212  and configured to interact with one or more ribs  5706  (two shown) and a shoulder  5708  defined near the base of the applicator cap  210 . The ribs  5704  may be configured to inter-lock between the ribs  5706  and the shoulder  5708  while attaching the applicator cap  210  to the housing  208 . More specifically, once the applicator cap  210  is snapped onto the housing  208 , the applicator cap  210  may be rotated (e.g., clockwise), which locates the ribs  5704  of the sheath  212  between the ribs  5706  and the shoulder  5708  of the applicator cap  210  and thereby “locks” the applicator cap  210  in place until the user reverse rotates the applicator cap  210  to remove the applicator cap  210  for use. Engagement of the ribs  5704  between the ribs  5706  and the shoulder  5708  of the applicator cap  210  may also prevent the sheath  212  from collapsing prematurely. 
     In  FIG.  57 C , the applicator cap  210  is removed from the housing  208 . As with the embodiment of  FIGS.  53 A- 53 C , the applicator cap  210  can be removed by reverse rotating the applicator cap  210 , which correspondingly rotates the cap post  5314  in the same direction and causes sensor cap  5018  to unthread from the mating member  5016 , as generally described above. Moreover, detaching the sensor cap  5018  from the sensor control device  5002  exposes the distal portions of the sensor  5010  and the sharp  5012 . 
     As the applicator cap  210  is unscrewed from the housing  208 , the ribs  5704  defined on the sheath  212  may slidingly engage the tops of the ribs  5706  defined on the applicator cap  210 . The tops of the ribs  5706  may provide corresponding ramped surfaces that result in an upward displacement of the sheath  212  as the applicator cap  210  is rotated, and moving the sheath  212  upward causes the sheath arms  5604  to flex out of engagement with the first detent  5702   a  to be received within the second detent  5702   b . As the sheath  212  moves to the second detent  5702   b , the radial shoulder  5614  moves out of radial engagement with the carrier arm(s)  5608 , which allows the passive spring force of the spring  5612  to push upward on the sharp carrier  5306  and force the carrier arm(s)  5608  out of engagement with the groove(s)  5610 . As the sharp carrier  5306  moves upward within the housing  208 , the mating member  5016  may correspondingly retract until it becomes flush, substantially flush, or sub-flush with the bottom of the sensor control device  5002 . At this point, the sensor applicator  102  in firing position. Accordingly, in this embodiment, removing the applicator cap  210  correspondingly causes the mating member  5016  to retract. 
       FIG.  58 A  is an isometric bottom view of the housing  208 , according to one or more embodiments. As illustrated, one or more longitudinal ribs  5802  (four shown) may be defined within the interior of the housing  208 . The ribs  5802  may be equidistantly or non-equidistantly spaced from each other and extend substantially parallel to centerline of the housing  208 . The first and second detents  5702   a,b  may be defined on one or more of the longitudinal ribs  5802 . 
       FIG.  58 B  is an isometric bottom view of the housing  208  with the sheath  212  and other components at least partially positioned within the housing  208 . As illustrated, the sheath  212  may provide or otherwise define one or more longitudinal slots  5804  configured to mate with the longitudinal ribs  5802  of the housing  208 . As the sheath  212  collapses into the housing  208 , as generally described above, the ribs  5802  may be received within the slots  5804  to help maintain the sheath  212  aligned with the housing during its movement. As will be appreciated, this may result in tighter circumferential and radial alignment within the same dimensional and tolerance restrictions of the housing  208 . 
     In the illustrated embodiment, the sensor carrier  5602  may be configured to hold the sensor control device  5002  in place both axially (e.g., once the sensor cap  5018  is removed) and circumferentially. To accomplish this, the sensor carrier  5602  may include or otherwise define one or more support ribs  5806  and one or more flexible arms  5808 . The support ribs  5806  extend radially inward to provide radial support to the sensor control device  5002 . The flexible arms  5808  extend partially about the circumference of the sensor control device  5002  and the ends of the flexible arms  5808  may be received within corresponding grooves  5810  defined in the side of the sensor control device  5002 . Accordingly, the flexible arms  5808  may be able to provide both axial and radial support to the sensor control device  5002 . In at least one embodiment, the ends of the flexible arms  5808  may be biased into the grooves  5810  of the sensor control device  5002  and otherwise locked in place with corresponding sheath locking ribs  5812  provided by the sheath  212 . 
     In some embodiments, the sensor carrier  5602  may be ultrasonically welded to the housing  208  at one or more points  5814 . In other embodiments, however, the sensor carrier  5602  may alternatively be coupled to the housing  208  via a snap-fit engagement, without departing from the scope of the disclosure. This may help hold the sensor control device  5002  in place during transport and firing. 
       FIG.  59    is an enlarged cross-sectional side view of the sensor applicator  102  with the sensor control device  5002  installed therein, according to one or more embodiments. As discussed above, the sensor carrier  5602  may include one or more carrier arms  5608  (two shown) engageable with the sharp carrier  5306  at corresponding grooves  5610 . In at least one embodiment, the grooves  5610  may be defined by pairs of protrusions  5902  defined on the sharp carrier  5306 . Receiving the carrier arms  5608  within the grooves  5610  may help stabilize the sharp carrier  5306  from unwanted tilting during all stages of retraction (firing). 
     In the illustrated embodiment, the arms  5304  of the sharp carrier  5306  may be stiff enough to control, with greater refinement, radial and bi-axial motion of the sharp hub  5014 . In some embodiments, for example, clearances between the sharp hub  5014  and the arms  5304  may be more restrictive in both axial directions as the relative control of the height of the sharp hub  5014  may be more critical to the design. 
     In the illustrated embodiment, the sensor carrier  5602  defines or otherwise provides a central boss  5904  sized to receive the sharp hub  5014 . In some embodiments, as illustrated, the sharp hub  5014  may provide one or more radial ribs  5906  (two shown). In at least one embodiment, the inner diameter of the central boss  5904  helps provide radial and tilt support to the sharp hub  5014  during the life of sensor applicator  102  and through all phases of operation and assembly. Moreover, having multiple radial ribs  5906  increases the length-to-width ratio of the sharp hub  5014 , which also improves support against tilting. 
       FIG.  60 A  is an isometric top view of the applicator cap  210 , according to one or more embodiments. In the illustrated embodiment, two axial slots  5703  are depicted that separate upper portions of the applicator cap  210  near its threading. As mentioned above, the slots  5703  may help the applicator cap  210  flex outward to be snapped into engagement with the housing  208  ( FIG.  57 B ). In contrast, the applicator cap  210  may be twisted (unthreaded) off the housing  208  by an end user. 
       FIG.  60 A  also depicts the ribs  5706  (one visible) defined by the applicator cap  210 . By interlocking with the ribs  5704  ( FIG.  57 C ) defined on the sheath  212  ( FIG.  57 C ), the ribs  5706  may help lock the sheath  212  in all directions to prevent premature collapse during a shock or drop event. The sheath  212  may be unlocked when the user unscrews the applicator cap  210  from the housing ( FIG.  59 C ), as generally described above. As mentioned herein, the top of each rib  5706  may provide a corresponding ramped surface  6002 , and as the applicator cap  210  is rotated to unthread from the housing  208 , the ribs  5704  defined on the sheath  212  may slidingly engage the ramped surfaces  6002 , which results in the upward displacement of the sheath  212  into the housing  208 . 
     In some embodiments, additional features may be provided within the interior of the applicator cap  210  to hold a desiccant component that maintains proper moisture levels through shelf life. Such additional features may be snaps, posts for press-fitting, heat-staking, ultrasonic welding, etc. 
       FIG.  60 B  is an enlarged cross-sectional view of the engagement between the applicator cap  210  and the housing  208 , according to one or more embodiments. As illustrated, the applicator cap  210  may define a set of inner threads  6004  and the housing  208  may define a set of outer threads  6006  engageable with the inner threads  6004 . As mentioned herein, the applicator cap  210  may be snapped onto the housing  208 , which may be accomplished by advancing the inner threads  6004  axially past the outer threads  6006  in the direction indicated by the arrow, which causes the applicator cap  210  to flex outward. To help ease this transition, as illustrated, corresponding surfaces  6008  of the inner and outer threads  6004 ,  6006  may be curved, angled, or chamfered. Corresponding flat surfaces  6010  may be provided on each thread  6004 ,  6006  and configured to matingly engage once the applicator cap  210  is properly snapped into place on the housing  208 . The flat surfaces  6010  may slidingly engage one another as the user unthreads the applicator cap  210  from the housing  208 . 
     The threaded engagement between the applicator cap  210  and the housing  208  results in a sealed engagement that protects the inner components against moisture, dust, etc. In some embodiments, the housing  208  may define or otherwise provide a stabilizing feature  6012  configured to be received within a corresponding groove  1914  defined on the applicator cap  210 . The stabilizing feature  6012  may help stabilize and stiffen the applicator cap  210  once the applicator cap  210  is snapped onto the housing  208 . This may prove advantageous in providing additional drop robustness to the sensor applicator  102 . This may also help increase the removal torque of the applicator cap  210 . 
       FIGS.  61 A and  61 B  are isometric views of the sensor cap  5018  and the collar  5112 , respectively, according to one or more embodiments. Referring to  FIG.  61 A , in some embodiments, the sensor cap  5018  may comprise an injection molded part. This may prove advantageous in molding the internal threads  5026   a  defined within the inner chamber  5022 , as opposed to installing a threaded core or threading the inner chamber  5022 . In some embodiments, one or more stop ribs  6102  (on visible) may be defined within the inner chamber  5022  to prevent over travel relative to mating member  5016  of the sharp hub  5014  ( FIGS.  50 A- 50 B ). 
     Referring to both  FIGS.  61 A and  61 B , in some embodiments, one or more protrusions  6104  (two shown) may be defined on the first end  5020   a  of the sensor cap  5018  and configured to mate with one or more corresponding indentations  6106  (two shown) defined on the collar  5112 . In other embodiments, however, the protrusions  6104  may instead be defined on the collar  5112  and the indentations  6106  may be defined on the sensor cap  5018 , without departing from the scope of the disclosure. 
     The matable protrusions  6104  and indentations  6106  may prove advantageous in rotationally locking the sensor cap  5018  to prevent unintended unscrewing of the sensor cap  5018  from the collar  5112  (and thus the sensor control device  5002 ) during the life of the sensor applicator  102  and through all phases of operation/assembly. In some embodiments, as illustrated, the indentations  6106  may be formed or otherwise defined in the general shape of a kidney bean. This may prove advantageous in allowing for some over-rotation of the sensor cap  5018  relative to the collar  5112 . Alternatively, the same benefit may be achieved via a flat end threaded engagement between the two parts. 
     Embodiments disclosed herein include: 
     U. A sensor control device that includes an electronics housing, a sensor arranged within the electronics housing and having a tail extending from a bottom of the electronics housing, a sharp extending through the electronics housing and having a sharp tip extending from the bottom of the electronics housing, and a sensor cap removably coupled at the bottom of the electronics housing and defining a sealed inner chamber that receives the tail and the sharp. 
     V. An analyte monitoring system that includes a sensor applicator, a sensor control device positioned within the sensor applicator and including an electronics housing, a sensor arranged within the electronics housing and having a tail extending from a bottom of the electronics housing, a sharp extending through the electronics housing and having a sharp tip extending from the bottom of the electronics housing, and a sensor cap removably coupled at the bottom of the electronics housing and defining an engagement feature and a sealed inner chamber that receives the tail and the sharp. The analyte monitoring system may further include a cap coupled to the sensor applicator and providing a cap post defining a receiver feature that receives the engagement feature upon coupling the cap to the sensor applicator, wherein removing the cap from the sensor applicator detaches the sensor cap from the electronics housing and thereby exposes the tail and the sharp tip. 
     W. A method of preparing an analyte monitoring system that includes loading a sensor control device into a sensor applicator, the sensor control device including an electronics housing, a sensor arranged within the electronics housing and having a tail extending from a bottom of the electronics housing, a sharp extending through the electronics housing and having a sharp tip extending from the bottom of the electronics housing, and a sensor cap removably coupled at the bottom of the electronics housing and defining a sealed inner chamber that receives the tail and the sharp. The method further including securing a cap to the sensor applicator, sterilizing the sensor control device with gaseous chemical sterilization while the sensor control device is positioned within the sensor applicator, and isolating the tail and the sharp tip within the inner chamber from the gaseous chemical sterilization. 
     Each of embodiments U, V, and W may have one or more of the following additional elements in any combination: Element 1: wherein the sensor cap comprises a cylindrical body having a first end that is open to access the inner chamber, and a second end opposite the first end and providing an engagement feature engageable with a cap of a sensor applicator, wherein removing the cap from the sensor applicator correspondingly removes the sensor cap from the electronics housing and thereby exposes the tail and the sharp tip. Element 2: wherein the electronics housing includes a shell matable with a mount, the sensor control device further comprising a sharp and sensor locator defined on an inner surface of the shell, and a collar received about the sharp and sensor locator, wherein the sensor cap is removably coupled to the collar. Element 3: wherein the sensor cap is removably coupled to the collar by one or more of an interference fit, a threaded engagement, a frangible member, and a frangible substance. Element 4: wherein an annular ridge circumscribes the sharp and sensor locator and the collar provides a column and an annular shoulder extending radially outward from the column, and wherein a seal member interposes the annular shoulder and the annular ridge to form a sealed interface. Element 5: wherein the annular ridge defines a groove and a portion of the sensor is seated within the groove, and wherein the seal member extends into the groove to seal about the portion of the sensor. Element 6: wherein the seal member is a first seal member, the sensor control device further comprising a second seal member interposing the annular shoulder and a portion of the mount to form a sealed interface. Element 7: wherein the electronics housing includes a shell matable with a mount, the sensor control device further comprising a sharp hub that carries the sharp and is engageable with a top surface of the shell, and a mating member defined by the sharp hub and extending from the bottom of the electronics housing, wherein the sensor cap is removably coupled to the mating member. Element 8: further comprising a collar at least partially receivable within an aperture defined in the mount and sealingly engaging the sensor cap and an inner surface of the shell. Element 9: wherein a seal member interposes the collar and the inner surface of the shell to form a sealed interface. Element 10: wherein the collar defines a groove and a portion of the sensor is seated within the groove, and wherein the seal member extends into the groove to seal about the portion of the sensor. 
     Element 11: wherein the receiver feature comprises one or more compliant members that flex to receive the engagement feature, and wherein the one or more compliant members prevent the engagement feature from exiting the cap post upon removing the cap from the sensor applicator. Element 12: further comprising a ramped surface defined on at least one of the one or more compliant members, and one or more camming surfaces provided by the engagement feature and engageable with the ramped surface, wherein the ramped surface and the one or more camming surfaces allow the cap and the cap post to rotate relative to the sensor cap in a first direction, but prevent the cap and the cap post from rotating relative to the sensor cap in a second direction opposite the first direction. Element 13: wherein the electronics housing includes a shell matable with a mount, the sensor control device further comprising a sharp hub that carries the sharp and is engageable with a top surface of the shell, and a mating member defined by the sharp hub and extending from the bottom of the electronics housing, wherein the sensor cap is removably coupled to the mating member and rotating the cap in the second direction detaches the sensor cap from the mating member. Element 14: wherein the electronics housing includes a shell matable with a mount and the sensor control device further includes a sharp and sensor locator defined on an inner surface of the shell, and a collar received about the sharp and sensor locator, wherein the sensor cap is removably coupled to the collar. 
     Element 15: wherein the cap provides a cap post defining a receiver feature and the sensor cap defines an engagement feature, the method further comprising receiving the engagement feature with the receiver feature as the cap is secured to the sensor applicator. Element 16: further comprising removing the cap from the sensor applicator, and engaging the engagement feature on the receiver feature as the cap is being removed and thereby detaching the sensor cap from the electronics housing and exposing the tail and the sharp tip. Element 17: wherein loading the sensor control device into a sensor applicator is preceded by sterilizing the tail and the sharp tip with radiation sterilization, and sealing the tail and the sharp tip within the inner chamber. 
     By way of non-limiting example, exemplary combinations applicable to U, V, and W include: Element 2 with Element 3; Element 2 with Element 4; Element 4 with Element 5; Element 4 with Element 6; Element 7 with Element 8; Element 8 with Element 9; Element 9 with Element 10; Element 11 with Element 12; and Element 15 with Element 16. 
     Sensor Applicator with Actuating Needle Shroud 
     Referring again briefly to  FIG.  1   , the sensor control device  104  is often included with the sensor applicator  104  in what is known as a “two-piece” architecture that requires final assembly by a user before the sensor  110  can be properly delivered to the target monitoring location. In such applications, the sensor  110  and the associated electrical components included in the sensor control device  104  are provided to the user in multiple (two) packages, and the user must open the packaging and follow instructions to manually assemble the components before delivering the sensor  110  to the target monitoring location with the sensor applicator  6302 . More recently, however, advanced designs of sensor control devices and associated sensor applicators have resulted in a one-piece architecture that allows the system to be shipped to the user in a single, sealed package that does not require any final user assembly steps. Rather, the user need only open one package, remove an applicator cap, and subsequently deliver the sensor control device to the target monitoring location. 
     Notwithstanding these advances, conventional sensor applicators commonly include a shroud that surrounds the entire outer periphery of the sensor control device. To deploy the sensor control device, the shroud is forced against the skin and retracts into the sensor applicator, which causes the combination introducer and sensor to be delivered transcutaneously under the user&#39;s skin. Having the shroud positioned away from the insertion site near the introducer leaves the skin at the insertion site in a generally soft and uncompressed state. It can be difficult to insert a sensor in uncompressed soft tissue due to the skin depression that occurs as the introducer tip enters the skin, commonly referred to as skin “tenting”. Embodiments of the present disclosure include sensor applicators that incorporate a needle shroud to apply pressure to the skin at or near the insertion site. 
       FIG.  62    is an isometric top view of an example sensor control device  6202 , according to one or more embodiments of the present disclosure. The sensor control device  6202  may be the same as or similar to the sensor control device  104  of  FIG.  1    and, therefore, may be designed to be delivered to a target monitoring location on a user&#39;s skin through operation of a sensor applicator (not shown). As illustrated, the sensor control device  6202  includes an electronics housing  6204  that is generally disc-shaped and may have a circular cross-section. In other embodiments, however, the electronics housing  6204  may exhibit other cross-sectional shapes, such as oval, ovoid (e.g., pill- or egg-shaped), a squircle, polygonal, or any combination thereof, without departing from the scope of the disclosure. The electronics housing  6204  may house or otherwise contain various electronic components used to operate the sensor control device  6202 . For example, a printed circuit board (PCB) may be positioned within the electronics housing and may have thereto one or more of a battery, a data processing unit, and various resistors, transistors, capacitors, inductors, diodes, and switches. 
     The electronics housing  6204  may include a shell  6206  and a mount  6208  that is matable with the shell  6206 . The shell  6206  may be secured to the mount  6208  via a variety of ways, such as a snap fit engagement, an interference fit, sonic welding, one or more mechanical fasteners (e.g., screws), or any combination thereof. In some cases, the shell  6206  may be secured to the mount  6208  such that a sealed interface is generated therebetween. In such embodiments, a gasket or other type of seal material may be positioned at or near the outer diameter (periphery) of the shell  6206  and the mount  6208 , and securing the two components together may compress the gasket and thereby generate a sealed interface. In other embodiments, an adhesive may be applied to the outer diameter (periphery) of one or both of the shell  6206  and the mount  6208 . The adhesive secures the shell  6206  to the mount  6208  and provides structural integrity, but may also seal the interface between the two components and thereby isolate the interior of the electronics housing  6204  from outside contamination. 
     In the illustrated embodiment, the sensor control device  6202  also includes a sensor module  6210  interconnectable with a sharp module  6212 . The sensor module  6210  may be coupled to the electronics housing  6204  with a collar  6214 , and the collar  6214  may be mounted to the electronics housing  6204  within an aperture  6215  defined therethrough. The sensor module  6210  may include a sensor  6216  and a flexible connector  6218  used to help connect the sensor  6216  to the electronic components housed within the electronics housing  6204 . A tail  6220  of the sensor  6216  may extend distally from the electronics housing  6204  and, more particularly, from the bottom of the mount  6208 . 
     The sharp module  6212  may carry or otherwise include an introducer or sharp  6222  used to help deliver the sensor  6216  transcutaneously under a user&#39;s skin during deployment of the sensor control device  6202 . In the illustrated embodiment, the sharp module  6212  includes a sharp hub  6224  that carries the sharp  6222 . In one embodiment, the sharp hub  6224  may be overmolded onto the sharp  6222 , but could alternatively be fabricated from plastic, metal, or another suitable material as a separate component, and bonded, welded, or mechanically attached to the sharp  6222 . Similar to the tail  6220 , the distal end of the sharp  6222  may extend distally from the electronics housing  6204  and, more particularly, from the bottom of the mount  6208 . In at least one embodiment, the tail  6220  may be received within a hollow or recessed portion of the sharp  6222 . 
     While the sensor control device  6202  is depicted as an eccentric assembly, with the sensor  6216  and the sharp  6222  extending distally at a location offset from a central axis of the electronics housing  6204 , embodiments are contemplated herein where the sensor  6216  and the sharp  6222  are aligned with the central axis in a concentric design, without departing from the scope of the disclosure. Moreover, an adhesive patch  6226  may be positioned on and otherwise attached to the underside of the mount  6208 . Similar to the adhesive patch  108  of  FIG.  1   , the adhesive patch  6226  may be configured to secure and maintain the sensor control device  6202  in position on the user&#39;s skin during operation. 
       FIG.  63    is a schematic side view of an example sensor applicator  6302 , according to one or more embodiments of the present disclosure. The sensor applicator  6302  may be similar in some respects to the sensor applicator  102  of  FIG.  1    and, therefore, may be configured to house and facilitate deployment of a sensor control device, such as the sensor control device  6202  (shown in dashed lines). As illustrated, the sensor applicator  6302  may include a housing  6304  sized to receive the sensor control device  6202  therein. In some embodiments, an applicator cap  6306  may be removably coupled to the housing  6304 . The applicator cap  6306  may be threaded to the housing  6304 , for example, but could alternatively be coupled thereto via a snap fit engagement, an interference fit, or the like, without departing from the scope of the disclosure. The applicator cap  6306  may help protect and shield the adhesive patch  6226  from contaminants or damage prior to deploying the sensor control device  6202 . 
     The sensor applicator  6302  may also include a sensor cap  6308  extending from the bottom of the sensor applicator  6302 . The sensor cap  6308  may be configured to receive and protect the distal ends of the sensor  6216  and the sharp  6222  extending from the bottom of the electronics housing  6204 . In some embodiments, the sensor cap  6308  may be coupled to or otherwise form an integral part or extension of the applicator cap  6306 . In other embodiments, however, the applicator and sensor caps  6306 ,  6308  may constitute separate component parts that may be jointly or separately removable from the bottom of the housing  6304 . 
     In some embodiments, the sensor cap  6308  may extend from the sensor control device  6202  and form part of a sterile barrier with the collar  6214  ( FIG.  62   ) to protect the distal ends of the sensor  6216  and the sharp  6222 . In such embodiments, the sensor cap  6308  may be removably coupled to the collar  6214 , such as being threaded to the collar  6214  or coupled thereto using a bayonet coupling, an interference fit, a snap fit engagement, or any combination thereof. In other embodiments, however, the sensor cap  6308  may alternatively be removably coupled to another internal feature of the sensor applicator  6302 , without departing from the scope of the disclosure. 
     In one or more embodiments, the sensor cap  6308  may include a gripping interface  6310  that provides a location for a user to grasp onto and remove the sensor cap  6308  from the sensor applicator  6302 . The gripping interface  6310  may comprise, for example, a tab that can be grasped by the user with the thumb and forefinger. Once the applicator cap  6306  and the sensor cap  6308  are removed, a user may then use the sensor applicator  6302  to position the sensor control device  6202  ( FIG.  62   ) at a target monitoring location on the user&#39;s body, as will be described below. 
       FIGS.  64 A and  64 B  are exploded isometric views of the sensor applicator  6302  and the sensor control device  6202 . The applicator cap  6306  and the sensor cap  6308  of  FIG.  63    are not shown for simplicity. As illustrated, the collar  6214 , the sensor  6216 , and the flexible connector  6218  (collectively the sensor module  6210  of  FIG.  62   ) may each be mounted to the electronics housing  6204  at or within the aperture  6215  defined in the electronics housing  6204 . 
     The sensor applicator  6302  may include a desiccant  6404 , a sensor retainer  6406 , a needle shroud  6408 , and a driver spring  6410 . The desiccant  6404  may optionally contained within the housing  6304  to help maintain appropriate humidity levels. The housing  6304  may be matable with the sensor retainer  6406  (alternately referred to as a “puck retainer”) to retain the needle shroud  6408 , the driver spring  6410 , the sharp hub  6224 , and the sharp  6222  within the housing  6304 . The sensor retainer  6406 , the needle shroud  6408 , the sharp hub  6224  with the sharp  6222 , and the driver spring  6410  may all be operatively coupled to help facilitate deployment of the sensor control device  6202 . 
     As described below, the needle shroud  6408  may be movable (actuatable) between an extended position and a retracted position to deploy the sensor control device  6202  from the sensor applicator  6302 . As best seen in  FIG.  64 B , the sensor retainer  6406  may have one or more locking tabs  6412  engageable with a corresponding one or more locking members  6414  provided on the needle shroud  6408 . Coupling the locking members  6414  to the locking tabs  6412  helps secure the needle shroud  6408  in the extended position, whereas disengaging the locking members  6414  from the locking tabs  6412  allows the needle shroud  6408  to move to the retracted position. 
     Those skilled in the art will readily appreciate that the locking tabs and members  6412 ,  6414  are merely one way to temporarily secure the needle shroud  6408  in the extended position. In other embodiments, for example, the locking tabs and members  6412 ,  6414  may be replaced with corresponding detents and mating grooves or other common types of removable or releasable couplings, without departing from the scope of the disclosure. 
     The sensor retainer  6406  may further include a plurality of upwardly extending fingers  6414  (three shown) configured to extend partially into the needle shroud  6408  to help retain the sharp hub  6224  until the needle shroud  6408  moves to the retracted position. Once the needle shroud  6408  reaches the retracted position, the fingers  6414  may be able to flex radially outward to release the needle shroud  6408 , and the spring force of the driver spring  6410  may retract the sharp  6222  into the housing  6304 . 
     The sensor retainer  6406  may define an aperture  6418  through which the lower portion of the needle shroud  6408  can extend. The lower end of the needle shroud  6408  extends through the aperture  6418  (and the aperture  6215  provided in the electronics housing  6204 ) when the needle shroud  6408  is in the extended position. Moving the needle shroud  6408  to the retracted position draws the lower end of the needle shroud  6408  upward through the aperture  6418  (and the aperture  6215  of the electronics housing  6204 ). 
       FIGS.  65 A- 65 D  are progressive cross-sectional side views of the sensor applicator  6302  depicting example deployment of the sensor control device  6202 , according to one or more embodiments. User operation (actuation) of the sensor applicator  6302  can cause the needle shroud  6408  to move from the extended position, as shown in  FIGS.  65 A and  65 B , to the retracted position, as shown in  FIG.  65 D . Once the needle shroud  6408  reaches the retracted position, the sensor control device  6202  may be able to be released (discharged) from the sensor retainer  6406 , as described below. 
     Referring first to  FIG.  65 A , the applicator cap  6306  is removably coupled to the housing  6304 . In some embodiments, the interface between the applicator cap  6306  and the housing  6304  may be sealed to help protect and shield the adhesive patch  6226  from contamination or damage prior to deploying the sensor control device  6202 . The sensor cap  6308  is also depicted extending distally from the bottom of the sensor applicator  6302  and, more particularly, from the sensor control device  6202 . 
     The sensor cap  6308  may define an interior  6502  sized to receive a lower portion of the needle shroud  6408  in the extended position. Moreover, distal ends of the sensor  6216  and the sharp  6222  may also extend into the interior  6502  of the sensor cap  6308  and the needle shroud  6408  may generally cover the distal ends of the sensor  6216  and the sharp  6222  when the needle shroud  6408  is in the extended position. In some embodiments, a seal  6504  may be positioned at an interface between the top of the sensor cap  6308  and the collar  6214  and thereby help form a sterile barrier for the sensor  6216  and the sharp  6222 . In one embodiment, the seal  6504  may be co-molded or otherwise attached to the top of the sensor cap  6308 . In other embodiments, however, the seal  6504  may be co-molded or attached to the collar  6214 . In yet other embodiments, the seal  6504  may be a separate component part, such as an O-ring or the like placed between the top of the sensor cap  6308  and the collar  6214 . 
     In one embodiment, as mentioned above, the sensor cap  6308  may be removably coupled to the collar  6214 , such as through a bayonet coupling, an interference fit, a snap fit engagement, or any combination thereof. In other embodiments, however, the sensor cap  6308  may be removably coupled to the needle shroud  6408 , without departing from the scope of the disclosure. Removably coupling the sensor cap  6308  to either the collar  6214  or the needle shroud  6408  may help maintain compression of the seal  6504 . To remove the sensor cap  6308  from the sensor applicator  6302 , a user may be able to grasp the gripping interface  6310  on the sensor cap  6308 . As indicated above, in some embodiments, both the applicator and sensor caps  6306 ,  6308  may be removed simultaneously or separately. 
     In  FIG.  65 B , the applicator cap  6306  and the sensor cap  6308  have been removed from the sensor applicator  6302 , thereby exposing the needle shroud  6408  and the bottom of the sensor control device  6202 . With the needle shroud  6408  in the extended position, as illustrated, the upper portion of the needle shroud  6408  resides within the housing  6304 , while the lower portion extends distally through the aperture  6418  defined in the sensor retainer  6406  and through the aperture  6215  defined through the sensor control device  6202 . The upwardly extending fingers  6414  of the sensor retainer  6406  may extend into or otherwise be positioned within an inner chamber  6506  defined by the upper portion of the needle shroud  6408 . Moreover, the sharp hub  6224  may be arranged within or between the fingers  6414 , and the driver spring  6410  may be arranged to interpose and engage the sharp hub  6224  and the sensor retainer  6406 . 
     More specifically, the top end of the driver spring  6410  may be received within a channel  6508  defined by the sharp hub  6224 , and the bottom end of the driver spring  6410  may engage one or more projections  6510  defined by the sensor retainer  6406  and extending radially into the aperture  6418 . Alternatively, the top end of the driver spring  6414  may engage an upper end of the sharp  6222 , thus eliminating the need for an overmolded sharp hub  6224 . The driver spring  6410  may be compressed between the sharp hub  6224  and the sensor retainer  6406  and prevented from releasing its spring force and expanding as long as the fingers  6414  are located within the inner chamber  6506 . More particularly, the top of one or more of the fingers  6414  may extend radially inward and over the sharp hub  6224 , thus preventing the sharp hub  6224  from moving upward until the fingers  6414  are no longer radially constrained by the inner chamber  6506 . Moving the needle shroud  6408  to the retracted position, however, correspondingly places the fingers  6414  outside of the inner chamber  6506 , which allows the driver spring  6410  force the sharp hub  6224  past the top of the fingers  6414 , as described below. 
     With the needle shroud  6408  in the extended position, the locking tabs  6412  ( FIG.  64 B ) of the sensor retainer  6406  may be engaged with the locking members  6414  ( FIGS.  64 A- 64 B ) provided on the needle shroud  6408 , which helps secure the needle shroud  6408  in the extended position. The locking members  6414  must be disengaged from the locking tabs  6412  to allow the needle shroud  6408  to move to the retracted position and thereby deploy the sensor control device  6202 . This can be accomplished by the user positioning the sensor applicator  6302  at the target monitoring location and forcing the needle shroud  6408  against the skin, which places an axial load on the bottom end of the needle shroud  6408 . The axial load will overcome the temporary engagement between the locking tabs  6412  and the locking members  6414 , thus freeing the needle shroud  6408  and enabling the needle shroud  6408  to start its transition to the retracted position. 
     In some embodiments, disengaging the locking members  6414  from the locking tabs  6412  may result in a tactile response, thus providing the user with haptic feedback. More particularly, upon disengaging the locking members  6414  from the locking tabs  6412 , a small vibration or tremor may result in the sensor applicator  6302 , thus indicating to a user that the deployment process has begun. This haptic feedback may encourage the user to continue to apply pressure to the needle shroud  6408 . 
     In some embodiments, one or more sensation features  6512  may be provided at the bottom end of the needle shroud  6408 . The sensation features  6512  may contact the underlying skin to stimulate the nerve endings on the skin at that location and thereby help to mask the sensation of the sharp  6222  penetrating the skin. In some embodiments, the sensation features  6512  may comprise nubs or small projections defined on the end of the needle shroud  6408 . 
     In  FIG.  65 C , the needle shroud  6408  has moved a short distance from the extended position and toward the retracted position, thus exposing the sensor  6216  and the sharp  6222  as they extend out of the lower end of the needle shroud  6408 . More specifically, as the needle shroud  6408  is pressed against the skin, it compresses the skin, and moves relative to the sensor  6216  and the sharp  6222 , which causes the sensor  6216  and the sharp  6222  to extend out of the needle shroud  6408  to penetrate the skin. One advantage of the needle shroud  6408  is its proximity to the insertion site of the sensor  6216  and the sharp  6222 . More particularly, the needle shroud  6408  is able to provide local compression of the skin at the insertion site, which tightens the skin at the insertion site and thereby facilitates a more efficient insertion of the sensor  6216  and the sharp  6222 . 
     Moving the needle shroud  6408  to the retracted position also moves the upper portion of the needle shroud  6408  relative to the fingers  6414  and the sharp hub  6224  arranged within the inner chamber  6506  of the needle shroud  6408 . Friction between the fingers  6414  and the inner wall of the inner chamber  6506  provides a small amount of resistance while allowing motion of the housing towards the skin surface, which can be felt by the user during firing to help drive the sharp  6222  into the underlying skin by applying additional pressure to bypass the force bump. 
     In  FIG.  65 D , the needle shroud  6408  has moved to the retracted position, and the bottom end of the needle shroud  6408  may be flush with or inset into the bottom of the sensor control device  6202 . Once the needle shroud  6408  has moved to the retracted position, the fingers  6414  of the sensor retainer  6406  may be positioned outside of the inner chamber  6506  and are therefore no longer radially constrained by the needle shroud  6408 . Consequently, the spring force built up in the driver spring  6410  may release and force the sharp hub  6224  against the tops of the fingers  6414 , which flexes the fingers  6414  radially outward and allows the sharp hub  6224  to move upward relative to the fingers  6414 . As the sharp hub  6224  moves upward, the sharp  6222  correspondingly retracts out of the underlying skin and into the sensor applicator  6302 , thus leaving only the sensor  6216  within the skin. 
     In some embodiments, the sensor applicator  6302  may provide haptic feedback to the user that provides an indication that the sensor deployment process is complete. More specifically, haptic or tactile feedback may be provided to the user when the needle shroud  6408  has moved to the retracted position and the sharp  6222  has fully retracted. In such embodiments, release of the driver spring  6410  may provide some degree of haptic feedback. However, springs, detents, or other elements may alternatively (or in addition) be included to also signal functionality and a completed firing process. In some applications, the forces generated by the experience may be tailored to be similar to taking a common retractable pen and pushing the thumb actuated “thruster” end against the skin. 
       FIG.  66    is an enlarged cross-sectional side view of an engagement between the sensor retainer  6406  and the sensor control device  6202 , according to one or more embodiments. In some embodiments, the collar  6214  may be removably coupled to the sensor retainer  6406 , which correspondingly retains the sensor control device  6202  to the sensor retainer  6406 . In the illustrated embodiment, the sensor retainer  6406  may provide or otherwise define one or more first retention features  6602  operable to mate with one or more corresponding second retention features  6604  defined on the collar  6214 . In the illustrated embodiment, the first and second retention features  6602 ,  6604  comprise tabs and corresponding lips or grooves that receive the tabs. However, the first and second retention features  6602 ,  6604  may comprise any type of removable coupling or engagement that temporarily couples the sensor control device  6202  to the sensor retainer  6406 . 
     The sensor control device  6302  may be released from the sensor retainer  6406  by disengaging the first and second retention features  6602 ,  6604 . This may be accomplished by attaching (sticking) the adhesive layer  6226  against the skin. The first and second retention features  6602 ,  6604  may be designed so that when the sensor control device  6202  is adhesively attached to the skin with the adhesive layer  6226 , the engagement between the first and second retention features  6602 ,  6604  may be broken by retracting the sensor applicator  6302  away from the sensor control device  6202 . This allows the sensor control device  6202  to separate from the sensor applicator  6302  and remain on the body. 
     In some embodiments, a seal  6606  may seal an interface between the top of the sensor control device  6202  and the bottom of the sensor retainer  6406 , and thereby help form a sterile barrier for the sensor  6216  and the sharp  6222 . In one embodiment, the seal  6606  may be co-molded or otherwise attached to the top of the sensor control device  6202  or the collar  6214 . In other embodiments, however, the seal  6606  may be co-molded or attached to the bottom of the sensor retainer  6406 . In yet other embodiments, the seal  6606  may be a separate component part, such as an O-ring or the like. 
       FIG.  67    is an exploded isometric view of another sensor applicator  6702  with the sensor control device  6202 , according to one or more additional embodiments. The sensor applicator  6702  may be similar in some respects to the sensor applicator  6302  of  FIGS.  63  and  64 A- 64 B  and may thus be best understood with reference thereto, where like numerals will correspond to like components not described again in detail. Similar to the sensor applicator  6302 , for example, the sensor applicator  6702  may include the housing  6304  that may be sized to accommodate the desiccant  6404  and the sensor control device  6202  therein. The collar  6214  and the sensor  6216  of the sensor control device  6202  may each be mounted to the electronics housing  6204  at or within the aperture  6215  defined in the electronics housing  6204 , as generally described above. Moreover, the sensor applicator  6702  may also include the sensor cap  6308  used to help form a sterile barrier with the collar  6214  and thereby protect the distal ends of the sensor  6216  and the sharp  6222 . As described above, the seal  6504  may help form the sterile barrier by sealing the interface between the top of the sensor cap  6308  and the collar  6214  (or another portion of the sensor control device  6202 ). 
     A sharp hub  6704  carries the sharp  6222  and may be overmolded onto the sharp  6222 , but could alternatively be fabricated from plastic, metal, or another suitable material as a separate component, and bonded, welded, or mechanically attached to the sharp  6222 . The sensor applicator  6702  may also include a sensor retainer  6706 , a needle shroud  6708 , and a driver spring  6710 . The sensor retainer  6706  (alternately referred to as a “puck retainer”) may be matable with the housing  6304  to help retain the needle shroud  6708 , the driver spring  6710 , and the sharp hub  6704  generally within or connected to the housing  6304 . More specifically, the sensor retainer  6706 , the needle shroud  6708 , the sharp hub  6704 , and the driver spring  6710  may all be operatively coupled to help facilitate deployment of the sensor control device  6202 . 
     In the illustrated embodiment, the driver spring  6710  may be sized to be arranged about the sharp hub  6704 , and the sensor retainer  6706  may provide a plurality of upwardly extending fingers  6712  (three shown) configured to extend into an inner chamber  6714  defined by the sharp hub  6704 . The sharp  6222  and the needle shroud  6708  may be extendable through the inner chamber  6714 , and further extendable through an aperture  6716  defined in the sensor retainer  6706  and the aperture  6215  provided in the electronics housing  6204 . The needle shroud  6708  may be movable (actuatable) between an extended position and a retracted position to deploy the sensor control device  6202  from the sensor applicator  6702 . 
     As described in more detail below, when the needle shroud  6708  is in the extended position, the fingers  6712  may be radially constrained between an outer surface of the needle shroud  6708  and an inner wall of the sharp hub  6704  within the inner chamber  6714 , thus preventing the sharp hub  6704  (and the sharp  6222 ) from moving. Once the needle shroud  6708  moves to the extended position, however, the fingers  6712  may become aligned with one or more reliefs  6718  defined on the needle shroud  6708 , which allow the fingers  6712  to flex radially inward and release the sharp hub  6704 . In some embodiments, the driver spring  6710  may provide a spring force that urges the sharp hub  6704  upward and simultaneously flexes the fingers  6712  radially inward, which allows the sharp hub  6704  to move upward and retract the sharp  6222  into the housing  6304 . 
       FIGS.  68 A- 68 D  are progressive cross-sectional side views of the sensor applicator  6702  depicting example deployment of the sensor control device  6202 , according to one or more embodiments. User operation (actuation) of the sensor applicator  6702  can cause the needle shroud  6708  to move from the extended position, as shown in  FIGS.  68 A and  68 B , to the retracted position, as shown in  FIG.  68 D . Once the needle shroud  6708  reaches the retracted position, the sensor control device  6202  may be able to be released (discharged) from the sensor retainer  6706 . 
     Referring first to  FIG.  68 A , an applicator cap  6802  may be removably coupled to the housing  6304  and may be similar in some respects to the applicator cap  6306  of  FIG.  63   . In some embodiments, the interface between the applicator cap  6802  and the housing  6304  may be sealed to help protect and shield the adhesive patch  6226  from contamination or damage prior to deploying the sensor control device  6202 . The sensor cap  6308  is also depicted extending distally from the bottom of the sensor applicator  6702  and, more particularly, from the sensor control device  6202 . The interior  6502  of the sensor cap  6308  may accommodate the distal ends of the sensor  6216  and the sharp  6222  and the lower portion of the needle shroud  6708  in the extended position. Moreover, the seal  6504  may interpose the top of the sensor cap  6308  and the collar  6214  to help form a sterile barrier for the sensor  6216  and the sharp  6222 . 
     In  FIG.  68 B , the applicator cap  6802  and the sensor cap  6308  have been removed from the sensor applicator  6702 , thereby exposing the needle shroud  6708  and the bottom of the sensor control device  6202 . With the needle shroud  6708  in the extended position, as illustrated, the upper portion of the needle shroud  6708  resides within the housing  6304 , while the lower portion extends distally through the aperture  6716  defined in the sensor retainer  6706  and through the aperture  6215  defined through the sensor control device  6202 . Moreover, the upper portion of the needle shroud  6708  extends into and through the inner chamber  6714  defined within the sharp hub  6704 . The upwardly extending fingers  6712  of the sensor retainer  6706  extend into the inner chamber  6714  and interpose the needle shroud  6708  and the inner wall of the inner chamber  6714 . 
     As indicated above, the driver spring  6710  may be positioned about an exterior portion of the sharp hub  6704  and may extend between the sharp hub  6704  and the sensor retainer  6706 . More specifically, the top end of the driver spring  6710  may be received within a channel  6806  defined by the sharp hub  6704 , and the bottom end of the driver spring  6710  may engage the sensor retainer  6706 , such as a top surface of the sensor retainer  6706 . The driver spring  6710  is compressed between the sharp hub  6704  and the sensor retainer  6706  when the needle shroud  6708  in the extended position. The driver spring  6710  is prevented from releasing its spring force and expanding as long as the fingers  6712  are radially constrained between the outer surface of the needle shroud  6708  and the inner wall of the inner chamber  6714 . More particularly, the tops of the fingers  6712  may extend radially outward and received within a groove or notch  6808  defined on the sharp hub  6704 . When the tops of the fingers  6712  are received within the notch(es)  6808 , the sharp hub  6704  may be prevented from moving upward. 
     Referring briefly to  FIG.  69 A , depicted is an enlarged schematic view of the sharp hub  6704  and the fingers  6712  of the sensor retainer  6706  of  FIG.  67   . As illustrated, the tops of each finger  6712  may extend or protrude radially outward to be received within corresponding notches  6808  defined at an upper end of the sharp hub  6704 . The fingers  6712  extend within the inner chamber  6714  and interpose the outer radial surface of the needle shroud  6708  and the inner wall of the inner chamber  6714 . The sharp hub  6704  is prevented from moving upward as long as the tops of the fingers  6712  are constrained into engagement with the notches  6808 . 
     Referring briefly to  FIGS.  69 B and  69 C , depicted are enlarged schematic views of the fingers  6712  interacting with the upper portion of the needle shroud  6708 . In some embodiments, as illustrated, the upper portion (end) of the needle shroud  6708  may define a groove  6902  and a detent profile  6904  that terminates in a force bump  6906 . In such embodiments, the upper ends of the fingers  6712  may provide or otherwise define inwardly extending (protruding) lips or features  6908  configured to interact with the groove  6902 , the detent profile  6904 , and the force bump  6906 . With the needle shroud  6708  in the extended position, the features  6908  provided on the fingers  6712  may be engaged with and otherwise received by the groove  6902  provided on the needle shroud  6708 , which helps axially maintain the needle shroud  6708  in the extended position. 
     The features  6908  must be disengaged from the groove  6902  to allow the needle shroud  6708  to move to the retracted position and thereby deploy the sensor control device  6202 . This can be accomplished by the user positioning the sensor applicator  6702  ( FIG.  68 B ) at the target monitoring location and forcing the bottom of the needle shroud  6708  against the skin, which places an axial load on the needle shroud  6708 . The axial load will overcome the temporary engagement between the groove  6902  and the features  6908 , thus freeing the needle shroud  6708  and enabling the needle shroud  6708  to start its upward transition to the retracted position. 
     As shown in  FIG.  69 C , the features  6908  have been disengaged from the groove  6902 , and the features  6908  may slide along the detent profile  6904  as the needle shroud  6708  moves upward relative to the fingers  6712 . When the features  6908  locate the force bump  6906 , the user may apply additional pressure to overcome and otherwise bypass the force bump  6906 . In some embodiments, disengaging the features  6908  from the groove  6902  or bypassing the force bump  6906  may result in a tactile response that may be felt by the user, thus providing the user with haptic feedback. More particularly, upon disengaging the features  6908  from the groove  6902  (or bypassing the force bump  6906 ), a small vibration or tremor may propagate through the sensor applicator  6702  ( FIG.  68 B ), thus indicating to a user that the deployment process has begun. This haptic feedback may encourage the user to continue to apply pressure to the needle shroud  6708 . 
     Referring again to  FIGS.  68 A- 68 D  and, more particularly, to  FIG.  68 C , the needle shroud  6708  has moved from the extended position and toward the retracted position, thus exposing the sensor  6216  and the sharp  6222  as they extend out the lower end of the needle shroud  6708 . More specifically, as the user presses the needle shroud  6708  against the skin, the needle shroud  6708  moves relative to the sensor  6216  and the sharp  6222 , which causes the sensor  6216  and the sharp  6222  to extend out of the bottom of the needle shroud  6708  to penetrate the skin. One advantage of the needle shroud  6708  is its proximity to the insertion site of the sensor  6216  and the sharp  6222 . More particularly, the needle shroud  6708  is able to provide local compression of the skin at the insertion site near the sharp  6222 , which tightens the skin at the insertion site and thereby facilitates a more efficient insertion of the sharp  6222  and the sensor  6216 . 
     Moving the needle shroud  6708  to the retracted position also moves the upper portion of the needle shroud  6708  relative to the fingers  6712  of the sensor retainer  6706  arranged within the inner chamber  6714  of the sharp hub  6704 . Friction between the fingers  6712  and the outer surface of the needle shroud  6708  provides a small amount of resistance, which may be felt by the user during firing to help drive the sharp  6222  into the underlying skin without user hesitation. 
     In  FIG.  68 D , the needle shroud  6708  has moved to the retracted position, which aligns the fingers  6712  with the reliefs  6718  defined in the sidewall of the needle shroud  6708 . Aligning the fingers  6712  with the reliefs  6718  allows the fingers  6712  to flex radially inward into the reliefs  6718  as the driver spring  6710  release and forces the sharp hub  6704  against the tops of the fingers  6712 . Once the fingers  6712  enter the reliefs  6718 , the sharp hub  6704  may be released and the spring force of the driver spring  6710  may move the sharp hub  6704  upward relative to the fingers  6712 , which correspondingly retracts the sharp  6222  into the sensor applicator  6702 , thus leaving only the sensor  6216  within the skin. 
     In some embodiments, the sensor applicator  6702  may provide haptic feedback to the user that provides an indication that the sensor deployment process is complete. More specifically, haptic or tactile feedback may be provided to the user when the needle shroud  6708  moves to the retracted position and the sharp  6222  has fully retracted. In such embodiments, release of the driver spring  6710  may provide some degree of haptic feedback that propagates through the sensor applicator  6702  to be felt by the user. However, springs, detents, or other elements may alternatively (or in addition) be included to also signal functionality and a completed firing process. In some applications, the forces generated by the experience may be tailored to be similar to taking a common retractable pen and pushing the thumb actuated “thruster” end against the skin. 
       FIGS.  70 A and  70 B  are enlarged cross-sectional side views of example engagement between the sensor retainer  6706  and the sensor control device  6202 , according to one or more embodiments. In some embodiments, the collar  6214  may be removably coupled to the sensor retainer  6706 , which correspondingly removably couples the sensor control device  6202  to the sensor retainer  6706 . In the illustrated embodiment, the sensor retainer  6706  may provide or otherwise define one or more first retention features  7002  operable to mate with one or more corresponding second retention features  7004  defined on the collar  6214 . In the illustrated embodiment, the first retention features  7002  comprise tabs that extend downwardly through the aperture  6716  of the sensor retainer  6706 , and the second retention features  7004  comprise corresponding lips or grooves that receive the tabs. However, the first and second retention features  7002 ,  7004  may comprise any type of removable coupling or engagement that temporarily couples the sensor control device  6202  to the sensor retainer  6706 . 
     As the needle shroud  6708  moves upward toward the retracted position, the first retention features  7002  may be radially constrained between an outer surface  7006  of the needle shroud  6708  and the collar  6214 , which prevents the first retention features  7002  from disengaging from the second retention features  7004 . Once the needle shroud  6708  reaches the retracted position, however, the first retention features  7002  may axially align with corresponding relief pockets  7008  defined in the sidewall of the needle shroud  6708 . Once the first retention features  7002  axially align with the relief pockets  7008 , the first retention features  7002  may be able to flex radially inward into the relief pockets  7008 , which allows the sensor control device  6302  to be released from the sensor retainer  6706 , as is shown in  FIG.  70 B . Flexing the first retention features  7002  radially inward may disengage the first and second retention features  7002 ,  7004 , thus allowing the sensor control device to release from the sensor retainer  6706 . 
     In some embodiments, the first and second retention features  7002 ,  7004  may be disengaged by attaching (sticking) the adhesive layer  6226  against the skin and pulling back on the sensor applicator  6702  ( FIGS.  68 A- 68 D ). More specifically, the first and second retention features  7002 ,  7004  may be designed so that when the sensor control device  6202  is adhesively attached to the skin with the adhesive layer  6226 , the engagement between the first and second retention features  7002 ,  7004  may be broken by retracting the sensor applicator  6702  away from the placed sensor control device  6202 . This allows the sensor control device  6202  to separate from the sensor applicator  6702  and remain on the body. 
       FIGS.  71 A and  71 B  are isometric and cross-sectional side views, respectively, of an example sensor retainer  7100 , according to one or more embodiments. The sensor retainer  7100  may be similar in some respects to the sensor retainers  6406 ,  6706  of  FIGS.  64 A- 64 B and  67   , respectively, and therefore may be best understood with reference thereto. Similar to the sensor retainers  6406 ,  6706 , for example, the sensor retainer  7100  may be configured to retain the sensor control device  6202  prior to deployment within a sensor applicator, such as any of the sensor applicators  102 ,  6302 ,  6702  of  FIGS.  1 ,  63 ,  67   , respectively, described herein. 
     In contrast to the sensor retainers  6406 ,  6706  of  FIGS.  64 A- 64 B and  67   , however, the sensor retainer  7100  may interact with a sharp hub  7102  that carries the sharp  6222  to releasably couple the sensor control device  6202  to the sensor retainer  7100 . As illustrated, the sensor retainer  7100  may define an aperture  7104  through which a lower portion of the sharp hub  7102  (and the sharp  6222 ) may extend. The aperture  7104  may align with the aperture  6215  defined in the electronics housing  6204  of the sensor control device  6202 , and the lower portion of the sharp hub  7102  may also extend into the aperture  6215  when the sensor control device  6202  is removably (releasably) coupled to the sensor retainer  7100 . 
     As illustrated, the sensor retainer  7100  may define or otherwise provide one or more arms  7106  that extend downwardly into the aperture  7104  and past the bottom of the sensor retainer  7100 . As best seen in  FIG.  71 B , each arm  7106  may provide or otherwise define one or more first retention features  7108  operable to mate with one or more corresponding second retention features  7110  defined on or otherwise provided by the sensor control device  6202 . In some embodiments, the second retention features  7110  may be provided by the collar  6214  ( FIGS.  62  and  67   ) positioned within the aperture  6215 , but could alternatively be provided on another part of the sensor control device  6202 , without departing from the scope of the disclosure. 
     In the illustrated embodiment, the first retention features  7108  may be provided at the bottom end of the arms  7106  and may comprise tabs or protrusions that extend (project) radially outward. The second retention feature  7110  may comprise a lip or annular shoulder extending radially inward at the aperture  6215  to receive and otherwise mate with the first retention features  7108 . Those skilled in the art will readily appreciate, however, that the first and second retention features  7108 ,  7110  may comprise any type of removable coupling or engagement that temporarily couples the sensor control device  6202  to the sensor retainer  6706 , without departing from the scope of the disclosure. 
       FIGS.  72 A and  72 B  are enlarged cross-sectional side views of the sensor retainer  7100  retaining the sensor control device  6202 . As illustrated, the lower portion of the sharp hub  7102  is received within the aperture  7104  of the sensor retainer  7100  and also extends at least partially through the aperture  6215  of the sensor control device  6202 . The sharp hub  7102  is shown in  FIGS.  72 A- 72 B  in an extended position, and may be movable to a retracted position where the sharp hub  7102  moves out of axial alignment with the apertures  6215 ,  7104 . Moving the sharp hub  7102  to the retracted position may be accomplished through user intervention in firing the sensor applicator that houses the sensor control device  6202 . Once the sensor applicator is fired, a spring or other biasing device (not shown) operatively coupled to the sharp hub  7102  may cause the sharp hub  7102  to quickly move upwardly relative to the sensor retainer  7100 . 
     With the sharp hub  7102  in the extended position, as depicted, the first retention features  7108  may be engaged with or otherwise mated to the second retention feature  7110 . Moreover, when the sharp hub  7102  is in the extended position, the arms  7106  may be radially constrained between the sidewall of the sharp hub  7102  and the second retention feature  7110 , which prevents the first retention features  7108  from disengaging from the second retention features  7110 . Once the sharp hub  7102  moves to the retracted position, however, the arms  7106  will no longer be backed by the sidewall of the sharp hub  7102 , thus enabling the arms  7106  to flex radially inward to disengage the first and second retention features  7108 ,  7110  and thereby release the sensor control device  6302 . 
     In some embodiments, the arms  7106  may flex radially inward to disengage the first and second retention features  7108 ,  7110  by attaching (sticking) the adhesive layer  6226  against the skin and pulling back on the sensor applicator that carries the sensor control device  6202 . More specifically, the first and second retention features  7108 ,  7110  may be designed so that when the sensor control device  6202  is adhesively attached to the skin with the adhesive layer  6226 , the engagement between the first and second retention features  7108 ,  7110  may be broken by retracting the sensor applicator away from the placed sensor control device  6202 . This allows the sensor control device  6202  to separate from the sensor applicator and remain on the body. 
     Electronics housings of prior sensor control devices are commonly manufactured of rigid plastic materials, and are retained within a sensor applicator by sensor retainers that have a plurality of flexible arms. Such electronics housings often define a plurality of semi-hemispherical notches or grooves on the outer periphery of the electronics housing that are sized to receive the ends of the flexible arms. According to embodiments of the present disclosure, however, the electronics housing  6204  of the sensor control device  6202  may be constructed of flexible or soft materials, such as a soft encapsulant, a foam, or small injection molded components. With flexible or soft materials, it can be a challenge to define features on the exterior of the electronics housing that can be used to retain the sensor control device  6202  to the sensor retainer  7100  during shipment and during the insertion process. 
     Accordingly, the sensor retainer  7100  includes the arms  7106  that help grasp and retain the sensor control device at the matable first and second retention features  7108 ,  7110 . The arms  7106  are flexible and capable of deflecting away from the second retention feature  7110  when the sensor control device  6202  is pulled from the sensor applicator by adhesive attachment to the skin. Prior to insertion, however, the arms  7106  are prevented from deflecting and releasing the sensor control device  6202  by the presence of the sharp hub  7102  extended within (through) the apertures  6215 ,  7104 . The sensor retainer  7100  may retain the sensor control device  6202  due to the arms  7106  not being able to deflect radially inwards. During the firing (insertion) process, however, and when the sharp  6222  and the sharp hub  7102  are retracted from the skin, the arms  7106  are no longer back supported and will be deflected as the sensor control device  6202  is pulled from the sensor applicator. 
     In addition to providing a method to retain the sensor control device  6202  in the sensor applicator, the features of the sensor retainer  7100  enable a more compact applicator design by replacing the flexible arms of conventional sensor retainers. By relocating the flexible retention arms to the apertures  6215 ,  7104 , the overall size of the sensor applicator may be reduced. 
       FIGS.  73 A and  73 B  are side and cross-sectional side views, respectively, of an example sensor applicator  7302 , according to one or more embodiments. The sensor applicator  7302  may be similar in some respects to the sensor applicator  102  of  FIG.  1    and, therefore, may be designed to deliver (fire) a sensor control device, such as the sensor control device  6202 . FIG.  73 A depicts how the sensor applicator  7302  might be shipped to and received by a user, and  FIG.  73 B  depicts the sensor control device  6202  arranged within the interior of the sensor applicator  7302 . 
     As shown in  FIG.  73 A , the sensor applicator  7302  includes a housing  7304  and an applicator cap  7306  removably coupled to the housing  7304 . In some embodiments, the applicator cap  7306  may be threaded to the housing  7304  and include a tamper ring  7308 . Upon rotating (e.g., unscrewing) the applicator cap  7306  relative to the housing  7304 , the tamper ring  7308  may shear and thereby free the applicator cap  7306  from the sensor applicator  7302 . 
     In  FIG.  73 B , the applicator cap  7306  has been removed from the housing  7304 , thus exposing a sheath  7310  that generally surrounds the sensor control device  6202 . During firing of the sensor applicator  7302 , the sheath  7310  may be actuated (e.g. pushed or forced into the housing  7304 ), which causes the sensor control device  6202  to be discharged from the sensor applicator  7302 . 
     In the illustrated embodiment, the sensor control device  6202  may include a sensor cap  7314  removably coupled to the sensor control device  6202  at or near the bottom of the electronics housing  6204 . The sensor cap  7314  may help provide or facilitate a sealed or sterile barrier surrounding and protecting the exposed portions of the sensor  6216  and the sharp  6222 . As illustrated, the sensor cap  7314  may comprise a generally cylindrical and elongate body having a first end  7315   a  and a second end  7315   b  opposite the first end  7315   a . The first end  7315   a  may be open to provide access into an inner chamber  7316  defined within the body, and the second end  7315   b  may be closed and may provide or otherwise define one or more engagement features  7318 . 
     In some embodiments, the sensor cap  7314  may be removably coupled to the sensor control device  6202  by being coupled to a sharp hub  7320  that carries the sharp  6222  and extends through the electronics housing  6204 . In such embodiments, the sharp hub  7320  may extend past the bottom of the electronics housing  6204  to provide a location where the sensor cap  7314  might engage the sharp hub  7320 . Consequently, at least a portion of the sharp hub  7320  may be extend into the inner chamber  7316  of the sensor cap  7314 . Prior to delivering the sensor control device  6202  to the target monitoring location on the user&#39;s skin, the sensor cap  7314  may be separated from the sharp hub  7320 . In some embodiments, the sensor cap  7314  may be removably coupled to the sharp hub  7320  via an interference or friction fit. In other embodiments, the sensor cap  7314  may be threaded to the sharp hub  7320 . In yet other embodiments, the sensor cap  7314  may be removably coupled to the sharp hub  7320  with a frangible member (e.g., a shear ring) or substance that may be broken with minimal separation force (e.g., axial or rotational force). In such embodiments, for example, the sensor cap  7314  may be secured to the sharp hub  7320  with a tag (spot) of glue or a dab of wax. 
     In some embodiments, however, the sharp hub  7320  may not extend past the bottom of the electronics housing  6204 . In such embodiments, the sensor cap  7314  may alternatively be removably coupled to another portion of the sensor control device  6202 , such as the collar  6214  ( FIGS.  62  and  67   ) or the mount  6208  ( FIG.  62   ). In such embodiments, the sensor cap  7314  may be removably coupled to the collar  6214  or the mount  6208  (or both) via an interference or friction fit, threading, with a frangible member or substance, or any combination thereof. 
     The inner chamber  7316  may be sized and otherwise configured to receive the distal ends of the sensor  6216  and the sharp  6222 . Moreover, the inner chamber  7316  may be sealed to isolate the sensor  6216  from substances that might adversely interact with the chemistry of the sensor  6216 . More specifically, the inner chamber  7316  may be sealed at the interface between the first end  7315   a  of the sensor cap  7312  and the location where it is removably coupled to the sensor control device  6202 . In some embodiments, a desiccant may be present within the inner chamber  7316  to help maintain preferred humidity levels. 
     As illustrated, the sensor applicator  7302  may further include an internal applicator cover  7322  that may extend at least partially into the sheath  7310 . The internal applicator cover  7322  may comprise a generally cylindrical body having a first end  7324   a  and a second end  7324   b  opposite the first end  7324   a . A sidewall of the internal applicator cover  7322  may extend between the first and second ends  7324   a,b  and into the interior of the sheath  7310  when the internal applicator cover  7322  is coupled to the sensor applicator  7302 . The internal applicator cover  7322  may be open at the first end  7324   a  to provide access to a cover interior  7326 . The second end  7324   b  may be closed and may provide or otherwise define a gripping interface  7328 . 
     In some embodiments, the internal applicator cover  7322  may be removably coupled to the sheath  7310 , such as via an interference fit or a threaded engagement. In other embodiments, the applicator cap  7306  ( FIG.  73 A ) may be used to help retain the internal applicator cover  7322  within the sensor applicator  7302  while applicator cap  7306  is coupled (threaded) to the housing  7304 . In yet other embodiments, the internal applicator cover  7322  may be coupled to the sensor cap  7312 . More particularly, the internal applicator cover  7322  may provide or otherwise define receiving features  7330  within the cover interior  7326  at or near the second end  7324   b . The receiving features  7330  may be configured to receive the second end  7315   b  of the sensor cap  7312  and, more particularly, mate with the engagement features  7318  of the sensor cap  7312 . 
     The internal applicator cover  7322  may be removed from the sensor applicator  7302  by a user grasping the gripping interface  7328  and rotating and/or pulling on the internal applicator cover  7322  relative to the shroud  7310  and out of engagement with the sensor applicator  7302 . As described below, as the internal applicator cover  7322  is removed, engagement between the receiving features  7330  and the engagement features  7318  causes the sensor cap  7312  to also be removed from the sensor control device  6202 , thus exposing the sensor  6216  and the sharp  6222  and readying the sensor control device  6202  for firing. 
       FIGS.  74 A and  74 B  are isometric top and bottom views, respectively, of the internal applicator cover  7322 . As depicted, the receiving features  7330  may be provided within the cover interior  7326  at or near the bottom of the internal applicator cover  7322 . As indicated above, the receiving features  7330  may be designed to receive the lower end  7315   b  ( FIG.  73 B ) of the sensor cap  7312  ( FIG.  73 B ) and mate with the engagement features  7318  ( FIG.  73 B ). As will be appreciated, many design variations of the engagement features  7318  and the receiving features  7330  may be employed, without departing from the scope of the disclosure. Any design may be used that allows the engagement features  7318  to be received by the receiving features  7330 , and subsequently prevent the sensor cap  7312  from separating from the receiving features  7330  upon removing the internal applicator cover  7322 . 
     In some embodiments, for example, the engagement and receiving features  7318 ,  7330  may comprise a threaded interface or a keyed mating profile that allows initial engagement but prevents subsequent disengagement. In the illustrated embodiment, the receiving features  7330  include one or more compliant members  7402  that are expandable or flexible to receive the engagement features  7318 . The receiving features  7330  may also include two or more planar members  7404  configured to receive the lower end  7315   b  ( FIG.  73 B ) of the sensor cap  7312  ( FIG.  73 B ) and prevent the sensor cap  7312  from rotating relative to the internal applicator cover  7322 . 
     In  FIG.  74 B , the gripping interface  7328  may comprise an upright flange  7406  extending across a depression  7408  formed into the second end  7324   b . A user may be able to grip the internal applicator cover  7322  with the thumb and forefinger at the upright flange  7406 , and apply a rotational or axial load to the internal applicator cover  7322  via the gripping interface  7328 . 
       FIG.  75    is an isometric view of an example embodiment of the sensor cap  7312 , according to one or more embodiments. In some embodiments, as illustrated, the first end  7315   a  of the sensor cap  7312  may provide or define a reduced-diameter portion  7502  that may help facilitate removable coupling engagement to the sensor control device  6202  ( FIG.  73 B ). 
     At the second end  7315   b , the engagement features  7318  may comprise, for example, an enlarged head or annular ring  7504  that can interact with the compliant members  7402  ( FIG.  74 A ) of the internal applicator cover  7322  ( FIG.  74 A ). The annular ring  7504  may alternatively comprise one or more radial protrusions. In some embodiments, the engagement features  7318  may also provide or otherwise define two or more planar surfaces  7506  configured to interact with the planar members  7404  ( FIG.  74 A ) of the internal applicator cover  7322 . In at least one embodiment, the planar surfaces  7506  may provide a hexagonal shape to the second end  7315   b  and may mate with the planar members  7404 . 
       FIG.  76    is an isometric, cross-sectional side view of the sensor cap  7312  received by the internal applicator cover  7322 , according to one or more embodiments. As illustrated, the engagement features  7318  are received within the receiving features  7330  of the internal applicator cover  7322 . More particularly, the annular ring  7504  is received by the compliant members  7402 , and the compliant members  7402  may comprise, for example, a collet-type device that includes a plurality of compliant fingers configured to flex radially outward to receive the annular ring  7504 . In other embodiments, however, the compliant members  7402  may comprise an elastomer or another type of compliant material configured to expand radially to receive the annular ring  7504 . Accordingly, as the sensor cap  7312  is extended into the receiving features  7330 , the compliant members  7402  may flex (expand) radially outward to receive the engagement features  7318 . Once the annular ring  7504  bypasses the compliant members  7402 , the compliant members  7402  flex back to their natural state and thereby prevent the sensor cap  7312  from disengaging from the internal applicator cover  7322 . 
     Mating the engagement features  7318  to the receiving features  7330  may also include mating the planar surfaces  7502  of the sensor cap  7312  with the planar members  7404  of the internal applicator cover  7322 . The opposing planar members and surfaces  7404 ,  7502  may bind the sensor cap  7312  rotationally such that the sensor cap  7312  is unable to rotate relative to the internal applicator cover  7322 . 
       FIG.  77    shows progressive removal of the applicator cap  7306  and the internal applicator cover  7322  from the sensor applicator  7302 , according to one or more embodiments. Moving from left to right in  FIG.  77   , the applicator cap  7306  may be removed by unscrewing it from the housing  7304 . Removing the applicator cap  7306  exposes the sheath  7310  and the bottom of the internal applicator cover  7322 . At this point, the sensor cap  7312  remains removably coupled to the sensor control device  6202  within the sensor applicator  7302 . Consequently, the sterile barrier facilitated by the sensor cap  7312  is not broken by removal of the applicator cap  7306 , and the sensor  6216  and the sharp  6222  remain protected. This feature may prove advantageous in the event the user changes his/her mind about firing the sensor applicator  7302  (i.e., deploying the sensor control device  6202 ) after removing the applicator cap  7306 . In the event of a decision change, the sensor  6216  and the sharp  6222  remain protected within the sensor cap  7312 , which is coupled to the internal applicator cover  7322 . 
     To be able to properly fire the sensor applicator  7302  and thereby deploy the sensor control device  6202 , the internal applicator cover  7322  must first be removed. As mentioned above, this can be done by the user gripping the internal applicator cover  7322  at the gripping interface  7328 . The user may then apply a rotational or axial load to the internal applicator cover  7322  via the gripping interface  7328  to remove the internal applicator cover  7322 . Upon removing the internal applicator cover  7322  from the sensor applicator  7302 , the receiving features  7330  ( FIG.  74 A ) of the internal applicator cover  7322  may retain the engagement features  7318  of the sensor cap  7312  and thereby prevent the sensor cap  7312  from separating from the receiving features  7330 . Instead, removing the internal applicator cover  7322  from the sensor applicator  7302  will simultaneously detach the sensor cap  7312  from the sensor control device  6202 , and thereby expose the distal portions of the sensor  6216  and the sharp  6222 . 
       FIG.  78    is a schematic diagram of an example sensor applicator  7800 , according to one or more additional embodiments of the present disclosure. Similar to the other sensor applicators described herein, the sensor applicator  7800  may be configured to house and subsequently deploy a sensor control device  7802 , which may be similar in some respects to any of the sensor control devices described herein. Alternatively, the sensor control device  7802  may comprise a type of medical device, a health care product, or a system that might require terminal sterilization of specific component parts. Example medical devices or health care products that may incorporate the principles of the present disclosure include, but are not limited to, ingestible products, cardiac rhythm management (CRM) devices, under-skin sensing devices, externally mounted medical devices, or any combination thereof. 
     In the illustrated embodiment, the sensor control device  7802  includes a housing  7804 , a part  7806  requiring sterilization, one or more radiation sensitive components  7808 , and a battery  7810  that provides power to the sensor control device  7802 . In the illustrated embodiment, the radiation sensitive component  7808  may comprise one or more electronic modules such as, but not limited to, a data processing unit (e.g., an application specific integrated circuit or ASIC), a resistor, a transistor, a capacitor, an inductor, a diode, and a switch. 
     In some embodiments, the part  7806  may comprise the sensor  6216  and the sharp  6222  described herein. As illustrated, the part  7806  may extend at an angle relative to the housing  7804 , but could alternatively extend perpendicular to the housing  7804 . In the illustrated embodiment, the part  7806  is arranged within a sterile chamber  7812  to protect the sensor  6216  and the sharp  6222  from external contamination. In some embodiments, the sterile chamber  7812  may have a desiccant arranged therein to help promote preferred humidity conditions. 
     The sensor  6216  and the sharp  6222  may be sterilized prior to being assembled in the sensor applicator  7800 , or alternatively while assembled in the sensor applicator  7800 . In at least one embodiment, the sensor  6216  and the sharp  6222  may be subjected to radiation sterilization to properly sterilize the part  7806  for use. Suitable radiation sterilization processes include, but are not limited to, electron beam (e-beam) irradiation, gamma ray irradiation, X-ray irradiation, or any combination thereof. 
     In some embodiments, the sensor control device  7802  may include a barrier shield  7814  positioned within the housing  7804  to help block radiation (e.g., electrons) from propagating within the housing  7804  toward the radiation sensitive components  7808 . The barrier shield  7814  may be made of a material that reduces or eliminates radiation from penetrating therethrough and thereby damaging the radiation sensitive components  7808  within the housing  7804 . The barrier shield  7814  may be made of a material having a density sufficient to absorb the dose of the beam energy being delivered. 
     In some embodiments, the sterile chamber  7812  may be comprise a cap that encapsulates the sensor  6216  and the sharp  6222  to provide a sealed barrier that protects exposed portions of the part  7806  until the part  7806  is placed in use. In such embodiments, the sterile chamber  7812  may be removable or detachable to expose the sensor  6216  and the sharp  6222 , as described below. Moreover, in such embodiments, the cap may be made of a material that permits propagation of radiation therethrough to facilitate radiation sterilization of the part  7806 . Suitable materials for the sterile chamber  7812  include, but are not limited to, a non-magnetic metal (e.g., aluminum, copper, gold, silver, etc.), a thermoplastic, a ceramic, rubber (e.g., ebonite), a composite material (e.g., fiberglass, carbon fiber reinforced polymer, etc.), an epoxy, or any combination thereof. In some embodiments, the sterile chamber  7812  may be transparent or translucent, but can otherwise be opaque, without departing from the scope of the disclosure. 
     In other embodiments, the sterile chamber  7812  may comprise a chamber or compartment defined within one or both of the sensor applicator  7800  and the sensor control device  7802 . In such embodiments, the sterile chamber  7812  may include a microbial barrier positioned at one or both ends of the sterile chamber  7812 . More specifically, the sterile chamber  7812  may provide or include an upper microbial barrier  7818   a  and a lower microbial barrier  7818   b  opposite the upper microbial barrier  7818   a . The upper and lower microbial barriers  7818   a,b  may help seal the sterile chamber  7812  and thereby isolate the sensor  6216  and the sharp  6222  from external contamination. The microbial barriers  7818   a,b  may be made of a radiation permeable material, such as a synthetic material (e.g., a flash-spun high-density polyethylene fiber). One example synthetic material comprises TYVEK®, available from DuPont®. In other embodiments, however, the microbial barriers  7818   a,b  may comprise, but are not limited to, tape, paper, film, foil, or any combination thereof. 
     In some embodiments, the part  7806  may be deployable and otherwise movable relative to the sensor applicator  7800 . In such embodiments, the sensor  6216  and the sharp  6222  may be advanced distally out of the sterile chamber  7812  and past the bottom of the electronics housing  7804  to allow the sensor  6216  and the sharp  6222  to be transcutaneously received beneath a user&#39;s skin. Distally advancing the part  7806  may be accomplished via a variety of mechanical or electromechancial means. In some embodiments, for example, the sensor applicator  7800  may include a plunger  7816  configured to advance distally to push the sensor  6216  and the sharp  6222  out of the sterile chamber  7812 . In such embodiments, the plunger  7816  may also be configured to attach to the sharp  6222  and subsequently retract the sharp  6222  while leaving the sensor  6216  extended. During operation, the plunger  7816  may penetrate the upper microbial barrier  7818   a  and force the sensor  6216  and the sharp  6222  distally through the lower microbial barrier  7818   b.    
     In other embodiments, the part  7806  may be advanced distally out of the sterile chamber  7812  using a magnetic coupling. More specifically, the sensor applicator  7800  may include a driver magnet  7820  movable within the sensor applicator  7800  and magnetically coupled to a driven magnet  7822  disposed on the part  7806 , such as on an upper end of the sharp  6222 . The driver magnet  7820  may be configured to advance distally and simultaneously push the sensor  6216  and the sharp  6222  out of the sterile chamber  7812  as magnetically coupled to the driven magnet  7822 . Once the sensor  6216  is properly placed, the driver magnet  7820  may be retracted proximally and simultaneously retract the sharp  6222  in the same direction while leaving the sensor  6216  extended. During operation, the driver magnet  7820  may cause the sensor  6216  and the sharp  6222  to penetrate distally through the lower microbial barrier  7818   b.    
     In embodiments where the sterile chamber  7812  comprises a cap, the plunger  7816  may also be operable to discharge or push the cap out of the sensor applicator  7800 . In such embodiments, a user may commence the firing process by priming the sensor applicator  7800 , which may cause the cap to be discharged from the sensor applicator  7800 . Further actuation of the sensor applicator  7800  by the user may cause the sensor  6216  and the sharp  6222  to be fully extended for subcutaneous implantation. In other embodiments, the cap may be removed either autonomously (e.g., it falls off or breaks away during firing) or the user may manually remove it by hand. 
     In some embodiments, the sensor applicator  7800  may further include an electrical connector  7824  in electrical communication with the electronics of the sensor control device  7802 , such as the radiation sensitive components  7808 . In at least one embodiment, the electrical connector  7824  may comprise one or more elastic pins made of a conductive polymer (e.g., a carbon impregnated polymer) and configured to facilitate electrical communication between the sensor  6216  and the radiation sensitive component  7808 . In such embodiments, the sensor  6216  may include one or more connectors  7826  alignable with the electrical connector  7824  when the part  7806  is advanced distally, as described above. Moreover, in embodiments where the sterile chamber  7812  comprises a cap, the electrical connector  7824  may be flexible to allow the cap to pass by the electrical connector  7824  until the connectors  7826  align with the electrical connector  7824 . 
       FIG.  79    is an exploded view of an example sensor control device  7900 , according to one or more additional embodiments. The sensor control device  7900  may be similar in some respects to any of the sensor control devices described herein. For example, the sensor control device  7900  may include a housing  7902  that contains or otherwise houses a battery  7904  that powers the sensor control device  7900  and one or more radiation sensitive components  7906 . The radiation sensitive component  7906  may be similar to the radiation sensitive component  7808  of  FIG.  78   , and therefore will not be described again. In some embodiments, the housing  7902  may be made of a flexible or deformable material. 
     The sensor control device  7900  may further include a sensor module  7908  that may be coupled to the housing  7902  to form the assembled sensor control device  7900 . As illustrated, the sensor module  7908  may include the sensor  6216  and the sharp  6222  extending distally therefrom. In the illustrated embodiment, the sensor  6216  and the sharp  6222  extend at an angle relative to the housing  7902 , but could alternatively extend perpendicular to the housing  7902 . 
     The sensor module  7908  may be sterilized separate from the housing  7902  to prevent damage to the radiation sensitive components  7906 . Following sterilization, the sensor module  7908  may be paired or coupled to the housing  7902  via a variety of permanent or removable attachment means. In some embodiments, for example, the sensor module  7908  may be coupled to the housing  7902  via a snap-fit engagement, an interference fit, or using one or more mechanical fasteners. In other embodiments, however, the sensor module  7908  may be coupled to the housing  7902  using an adhesive, sonic welding, or laser welding. Pairing the sensor module  7908  to the housing  7902  may be done during manufacturing or may be accomplished by a user prior to deploying the sensor control device. 
     Coupling the sensor module  7908  to the housing  7902  may also facilitate communication between the sensor  6216  and the radiation sensitive components  7906 . More particularly, in some embodiments, the sensor module  7908  may include one or more sensor contacts  7910  alignable with one or more electrical connectors  1912  provided on the housing  7902  when the sensor module  7908  is coupled to the housing  7902 . The sensor contacts  7910  and the electrical connectors  1912  may comprise one or more elastic pins made of a conductive polymer (e.g., a carbon impregnated polymer) and configured to facilitate electrical communication between the sensor  6216  and the radiation sensitive component  7906 . 
       FIG.  80    is a bottom view of one embodiment of the sensor control device  7900  of  FIG.  79   . As illustrated, the housing  7902  exhibits a generally polygonal cross-sectional shape and, more particularly, a triangular shape with rounded corners. In other embodiments, however, the housing  7902  may exhibit other cross-sectional shapes including, but not limited to, circular, oval, ovoid, or other polygonal shapes (e.g., square, rectangular, pentagonal, etc.), without departing from the scope of the disclosure. 
     In the illustrated embodiment, the sensor module  7908  may be coupled to the housing  7902  via a snap-in or snap-fit engagement. More specifically, the housing  7902  may define a cavity  8002  sized to receive the sensor module  7908 , and one or both of the housing  7902  and the sensor module  7908  may define or otherwise provide tabs  8004  configured to matingly engage when the sensor module  7908  is received within the cavity  8002 . The tabs  8004  may mate to secure the sensor module  7908  within the cavity  8002 . As will be appreciated, the tabs  8004  may be replaced with any other type of device or mechanism that facilitates a snap-in or snap-fit engagement, without departing from the scope of the disclosure. As indicated above, coupling the sensor module  7908  to the housing  7902  may be done during manufacturing or may be accomplished by a user prior to deploying the sensor control device. 
     Embodiments disclosed herein include: 
     X. A sensor applicator that includes a housing and a sensor retainer arranged within the housing, a sensor control device removably coupled to the sensor retainer and including an electronics housing, a sensor arranged within the electronics housing and extending from a bottom of the electronics housing, and a sharp hub that carries a sharp extending through the electronics housing and from the bottom of the electronics housing. The sensor application further includes a needle shroud extendable through the sensor retainer and the electronics housing and movable between an extended position, where the needle shroud extends past the bottom of the electronics housing and covers distal ends of the sensor and the sharp, and a retracted position, where the needle shroud retracts into the housing and thereby exposes the distal ends of the sensor and the sharp. 
     Y. A method of deploying a sensor control device from a sensor applicator that includes positioning the sensor applicator adjacent a target monitoring location, the sensor applicator including a housing and a sensor retainer arranged within the housing, wherein the sensor control device is removably coupled to the sensor retainer and includes an electronics housing, a sensor arranged within the electronics housing and extending from a bottom of the electronics housing, and a sharp hub that carries a sharp extending through the electronics housing and from the bottom of the electronics housing. The method further includes aligning a needle shroud with the target monitoring location, the needle shroud extending through the sensor retainer and the electronics housing, engaging the needle shroud against the target monitoring location to move the needle shroud from an extended position, where the needle shroud extends past the bottom of the electronics housing and covers distal ends of the sensor and the sharp, and pushing on the sensor applicator to move the needle shroud to a retracted position, where the needle shroud retracts into the housing and exposes the distal ends of the sensor and the sharp to transcutaneously receive the sensor at the target monitoring location. 
     Each of embodiments X and Y may have one or more of the following additional elements in any combination: Element 1: further comprising a sensor cap defining an inner chamber that receives the distal ends of the tail and the sharp and forms a sterile barrier that protects the distal ends of the sensor and the sharp. Element 2: further comprising an applicator cap removably coupled to the housing, wherein the applicator cap and the sensor cap are simultaneously removable from the housing. Element 3: wherein the sensor cap extends from the sensor control device. Element 4: wherein the sensor control device further includes a collar coupled to the electronics housing, and wherein the sensor cap is removably coupled to the collar. Element 5: wherein the sensor cap provides a gripping interface for a user to grasp onto and remove the sensor cap from the sensor applicator. Element 6: wherein the needle shroud is received within the sensor cap when the needle shroud is in the extended position. Element 7: further comprising one or more first retention features provided on the sensor retainer, one or more second retention features provided on the sensor control device and matable with the one or more first features, wherein disengaging the one or more second retention features from the one or more first features deploys the sensor control device for use. Element 8: wherein the sensor retainer provides a plurality of upwardly extending fingers engageable with the sharp hub to prevent the sharp hub from moving relative to the sensor retainer when the needle shroud is in the extended position. Element 9: wherein the plurality of fingers are extendable into an upper portion of the needle shroud and interpose the sharp hub and an inner wall of the upper portion of the needle shroud when the needle shroud is in the extended position. Element 10: further comprising a driver spring compressed between the sharp hub and the sensor retainer when the needle shroud is in the extended position, wherein moving the needle shroud to the retracted positon allows the driver spring to expand and move the sharp hub to retract the sharp into the housing. Element 11: wherein the plurality of fingers are extendable into the sharp hub and interpose the needle shroud and an inner wall of the sharp hub when the needle shroud is in the extended position. Element 12: further comprising a driver spring compressed between the sharp hub and the sensor retainer when the needle shroud is in the extended position, wherein moving the needle shroud to the retracted positon allows the driver spring to expand and move the sharp hub to retract the sharp into the housing. Element 13: wherein the needle shroud defines a groove at an upper end and the plurality of fingers provide inwardly extending features engageable with the groove to help maintain the needle shroud in the extended position. Element 14: wherein the sensor retainer includes one or more locking tabs matable with one or more locking members provided on the needle shroud to secure the needle shroud in the extended position. 
     Element 15: further comprising forming a sterile barrier with a sensor cap that receives the distal ends of the tail and the sharp, wherein the needle shroud is received within the sensor cap when the needle shroud is in the extended position, and removing the sensor cap prior to engaging the needle shroud against the target monitoring location. Element 16: wherein one or more first retention features provided on the sensor retainer are matable with one or more second retention features provided on the sensor control device to couple the sensor control device to the sensor retainer, the method further comprising adhesively attaching the sensor control device to the target monitoring location, and pulling the sensor applicator away from the target monitoring location to disengage the one or more second retention features from the one or more first retention features and thereby detach the sensor control device from the sensor retainer. Element 17: wherein the sensor retainer provides a plurality of upwardly extending fingers engageable with the sharp hub, the method further comprising preventing the sharp hub from moving relative to the sensor retainer with the plurality of fingers when the needle shroud is in the extended position. Element 18: wherein the plurality of fingers are extendable into an upper portion of the needle shroud and interpose the sharp hub and an inner wall of the upper portion of the needle shroud when the needle shroud is in the extended position, the method further comprising moving the sharp hub to retract the sharp into the housing when the needle shroud moves to the retracted position with a driver spring extending between the sharp hub and the sensor retainer. Element 19: wherein the plurality of fingers are extendable into the sharp hub and interpose the needle shroud and an inner wall of the sharp hub when the needle shroud is in the extended position, the method further comprising moving the sharp hub to retract the sharp into the housing when the needle shroud moves to the retracted position with a driver spring extending between the sharp hub and the sensor retainer. 
     By way of non-limiting example, exemplary combinations applicable to X and Y include: Element 1 with Element 2; Element 1 with Element 3; Element 3 with Element 4; Element 1 with Element 5; Element 1 with Element 6; Element 8 with Element 9; Element 9 with Element 10; Element 8 with Element 11; Element 11 with Element 12; Element 11 with Element 13; Element 15 with Element 16; Element 17 with Element 19; and Element 17 with Element 19. 
     Localized Axial-Radial Sensor Seal for Analyte Monitoring 
     Referring briefly again to  FIG.  1   , the system  100  may comprise what is known as a “two-piece” architecture that requires final assembly by a user before the sensor  110  can be properly delivered to the target monitoring location. According to embodiments of the present disclosure, the sensor control device assembly of  FIG.  1    may instead comprise a one-piece architecture that incorporates sterilization techniques specifically designed for a one-piece architecture. The one-piece architecture allows the sensor control device assembly to be shipped to the user in a single, sealed package that does not require any final user assembly steps. Rather, the user need only open one package and subsequently deliver the sensor control device to the target monitoring location. The one-piece system architecture described herein may prove advantageous in eliminating component parts, various fabrication process steps, and user assembly steps. As a result, packaging and waste are reduced, and the potential for user error or contamination to the system is mitigated. 
       FIGS.  81 A and  81 B  are isometric and side views, respectively, of an example sensor control device  8102 . The sensor control device  8102  may be similar in some respects to the sensor control device  104  of  FIG.  1    and therefore may be best understood with reference thereto. In some applications, the sensor control device  8102  may replace the sensor control device  104  of  FIG.  1    and, therefore, may be used in conjunction with the analyte monitoring system  100  ( FIG.  1   ) or the sensor applicator  102 , which delivers the sensor control device  8102  to a target monitoring location on a user&#39;s skin. 
     The sensor control device  8102  includes an electronics housing  8104  that is generally disc-shaped and may have a circular cross-section. In other embodiments, however, the electronics housing  8104  may exhibit other cross-sectional shapes, such as ovoid or polygonal and may be non-symmetrical. The electronics housing  8104  may include a shell  8106  and a mount  8108  configured to engage or couple with the shell  8106 . The shell  8106  may be secured to the mount  8108  via a variety of ways, such as a snap fit engagement, an interference fit, sonic (or ultrasonic) welding, using one or more mechanical fasteners (e.g., screws), or any combination thereof. In some embodiments, the interface between the shell  8106  and the mount  8108  may be sealed. In such embodiments, a gasket or other type of seal material may be positioned or applied at or near the outer diameter (periphery) of the shell  8106  and the mount  8108 . Securing the shell  8106  to the mount  8108  may compress the seal material and thereby generate a sealed interface. In at least one embodiment, an adhesive may be applied to the outer diameter (periphery) of one or both of the shell  8106  and the mount  8108 , and the adhesive may not only secure the shell  8106  to the mount  8108  but may also seal the interface. 
     In embodiments where a sealed interface is created between the shell  8106  and the mount  8108 , the interior of the electronics housing  8104  may be effectively isolated from outside contamination between the two components. In such embodiments, if the sensor control device  8102  is assembled in a controlled and sterile environment, there may be no need to sterilize the internal electrical components (e.g., via gaseous chemical sterilization). Rather, the sealed engagement may provide a sufficient sterile barrier for the assembled electronics housing  8104 . 
     The sensor control device  8102  may further include a sensor  8110 , a sharp module  8112  engaged with the sensor  8110 . The sensor  8110  and the sharp module  8112  may be interconnectable and may be coupled to the electronics housing  8104 . The sharp module  8112  may be configured to carry and otherwise include a sharp  8116  used to help deliver the sensor  8110  transcutaneously under a user&#39;s skin during application of the sensor control device  8102 . 
     As best seen in  FIG.  81 B , corresponding portions of the sensor  8110  and the sharp  8116  extend from the electronics housing  8104  and, more particularly, from the bottom of the mount  8108 . The exposed portion of the sensor  8110  may be received within a hollow or recessed portion of the sharp  8116 . The remaining portion(s) of the sensor  8110  is/are positioned within the interior of the electronics housing  8104 . 
       FIG.  82    is an exploded perspective top view of the sensor control device  8102 , according to one or more embodiments. As illustrated, the shell  8106  and the mount  8108  of the electronics housing  8104  may operate as opposing clamshell halves that enclose or otherwise substantially encapsulate the various electronic components of the sensor control device  8102 . Various electrical components may be positioned within the electronics housing  8104 , including a printed circuit board (PCB)  8202  having a plurality of electronic modules  8204  and a battery  8205  mounted to the PCB  8202 . The battery  8205  may be configured to power the sensor control device  8102 . Example electronic modules  8204  include, but are not limited to, resistors, transistors, capacitors, inductors, diodes, integrated circuits, and switches. A data processing unit  8206  ( FIG.  82   ) may also be mounted to the PCB  8202  and may comprise, for example, an application specific integrated circuit (ASIC) configured to implement one or more functions or routines associated with operation of the sensor control device  8102 . More specifically, the data processing unit  8206  may be configured to perform data processing functions, such as filtering and encoding of data signals, each of which corresponds to a sampled analyte level of the user. The data processing unit  8206  may also include or otherwise communicate with an antenna for communicating with the reader device  106  ( FIG.  1   ). As shown in  FIG.  82   , the PCB  8202  and various components mounted to it may be encapsulated or otherwise contained within an encapsulating material  8207 . 
     As illustrated in  FIG.  82   , the shell  8106 , the mount  8108 , and the PCB  8202 , and encapsulating material  8207  each define corresponding channels or apertures  8208   a ,  8208   b ,  8208   c ,  8208   d , respectively. Due to their placement with respect to the outer surface of electronics housing  8104 , aperture  8208   a  in the shell  8106  may be referred to as a top aperture, and aperture  8208   b  in the mount  8108  may be referred to as a bottom aperture. The mount  8108  further includes a channel  8210  that extends upward from aperture  8208   b  and a slot  8212  that extends through a side wall of channel  8210 . When the sensor control device  8102  is assembled, the apertures  8208   a - c  align and the channel  8210  extends through apertures  8208   a ,  8208   c ,  8208   d  to receive portions of the sensor  8110  and the sharp module  8112  therethrough. The centers or central regions of apertures  8208   a ,  8208   b ,  8208   c ,  8208   d  and channel  8210  are arranged in an eccentric manner with respect to electronics housing  8104 , being spaced apart from the sensor central axis  8105 . The sharp  8110  and sensor  8110 , which may extend through at least one of these apertures and channel  8210 , are likewise spaced apart from the sensor central axis  8105  and are arranged in an eccentric manner. 
     The sensor control device  8102  may further include a housing support  8250  to be located in electronics housing  8104  in the vicinity of apertures  8208   a ,  8208   b ,  8208   c ,  8208   d  to provide support between shell  8106  and mount  8108 . The illustrated embodiment, housing support  8250  for electronics housing  8104  is a collar  8250 . The collar  8250  may exhibit a variety of shapes, such as cylindrical, tubular, annular, polygonal, or any combination thereof. 
     The sensor  8110  includes a tail  8216 , a flag  8218 , and a neck  8220  that interconnects the tail  8216  and the flag  8218 . The central aperture  8208   b  and channel  8210  defined in the mount  8108  may be configured to receive the tail  8216 , which may extend therethrough and extend distally from the underside thereof. The slot  8212  in the mount  8108  may be configured to receive the sensor neck  8220 , allowing the flag  8218  to extend to or toward the PCB  8202 . The tail  8216  includes an enzyme or other chemistry or biologic and, in some embodiments, a membrane may cover the chemistry. In use, the tail  8216  is transcutaneously received beneath a user&#39;s skin, and the chemistry included thereon helps facilitate analyte monitoring in the presence of bodily fluids. 
     The flag  8218  may comprise a generally planar surface having one or more sensor contacts  8222  (two shown in  FIG.  82   ) disposed thereon. The flag  8218  or the contacts  8222  are configured to couple electrically to the PCB  8202  or modules on PCB  8202 , which may include a corresponding number of contacts (not shown), such as contacts on compliant carbon impregnated polymer modules for example. 
     The sharp module  8112  includes the sharp  8116  and a sharp hub  8230  that carries the sharp  8116 . The sharp  8116  includes an elongate shaft  8232  and a sharp tip  8234  at the distal end of the shaft  8232 . The shaft  8232  may be configured to extend through each of the coaxially aligned central apertures  8208   a - c  and extend distally from the bottom of the mount  8108 . Moreover, the shaft  8232  may include a hollow or recessed portion  8236  that at least partially circumscribes the tail  8216  of the sensor  8110 . The sharp tip  8234  may be configured to penetrate the skin while carrying the tail  8216  to put the active chemistry of the tail  8216  into contact with bodily fluids. 
     The sharp hub  8230  may include a hub small cylinder  8238  and a hub snap pawl  8240 , each of which may be configured to help couple the sensor control device  8102  to the sensor applicator  102  ( FIG.  1   ). 
     An adhesive or adhesive patch (not shown), similar to the adhesive patch  108  of  FIG.  1   , may be positioned on and otherwise attached to the bottom  8111  of the mount  8108 . As discussed above, the adhesive patch may be configured to secure and maintain the sensor control device  8102  in position on the user&#39;s skin during operation. 
       FIG.  83    is a cross-sectional side view of a sensor control device assembly  8310  having a central or longitudinal assembly axis  8311  and including a sensor applicator  8312  with a cap  8330  coupled thereto and the sensor control device  8102  installed inside. In some applications, the sensor control device assembly  8310  with its sensor control device  8102  and applicator  8312  may replace the sensor control device  104  and the applicator  102  of  FIG.  1    and, therefore, may be used in conjunction with the analyte monitoring system  100  ( FIG.  1   ). 
     The cap  8330  may be threaded to the sensor applicator  8312  and may include a tamper-evident ring or wrap (not shown) to evidence or inhibit premature unthreading. Moreover, the cap  8330  may define an undercut  8313  at the base of the threaded interface that provides additional stiffness in tilting at the interface between the cap  8330  and the housing  8314  and a detent force that may need to be overcome for the cap  8330  to unscrew. Upon rotating (e.g., unscrewing) the cap  8330  relative to sensor applicator  8312 , the tamper ring or wrap may shear and thereby free the cap  8330  and desiccant  8315  from the sensor applicator  8312 . Following which, the user may deliver the sensor control device  8102  to the target monitoring location. 
     The sensor applicator  8312  includes a housing  8314  that is disposed around and slidingly coupled to a sheath  8318  and is configured to move a prescribed axial distance relative to the sheath  8318 . Sheath  8318  defines a bottom for sensor applicator  8312 , the bottom that rests against a user&#39;s skin, for example, when sensor control device assembly  8310  is used to place a sensor control device  8102  on the user. Sensor applicator  8312  also includes a sharp carrier  8360  and a sensor carrier  8364  interposed between the sheath  8318  and sharp carrier  8360 . Sensor carrier  8364  includes a radially extending platform  8366  located below sharp carrier  8360 , which may rest on the platform  8366 . Platform  8366  is coupled to housing  8314  to move when housing  8314  moves axially relative to sheath  8318 . 
     The cap  8330  may include an outer shell  8332  that extends from a threaded first end  8333  to a bottom or second end  8334 . A base  8336  may be located at the second end  8334 , a support structure  8338  may extend from the base  8336  upward toward the first end  8333 , and a post  8350  extending from the support structure  8338 . Likewise, when installed, support structure  8338  may extend upward from the bottom of the sheath  8318  of the sensor applicator  8312 . The support structure  8338  is located within the outer shell  8332  and includes an inner shell  8340  supported by a plurality of ribs  8342 . Viewed from base  8336 , inner shell  8340  is concave. The post  8350  is centrally located within the interior of the cap  8330  and may be aligned with assembly axis  8311 . The post  8350  extends downward from a first end  8353  at the top of inner shell  8340  to a second end  8354  closer to cap base  8336 . The post  8350  defines a post chamber  8356 , which is open at first end  8353  and closed at second end  8354 . 
     The support structure  8338  or the post  8350  may be configured to help support the sensor control device  8102  while contained within the sensor applicator  8312 . Moreover, the post chamber  8356  is configured to receive the sensor  8110  and the sharp  8116  when extending from the bottom of the electronics housing  8104 . When the sensor control device  8102  is loaded into the sensor applicator  8312 , the sensor  8110  and the sharp  8116  may be arranged within a sealed region  8370  at least partially defined by the post chamber  8356  and configured to isolate the sensor  8110  and the sharp  8116  from various other regions in sensor control device assembly  8310 , which may contain various fluids or contaminants at various times. 
     The cap  8330  provides a barrier against outside contamination, and thereby maintains a sterile environment for the sensor control device assembly  8310 , including the sensor control device  8102  contained therein, until the user removes (unthreads) the cap  8330 . The cap  8330  may also create a dust-free environment during shipping and storage. 
     A desiccant  8315  may be included in cap  8330 , being located within the outer volume of the inner shell  8340 , and a cover member or seal  8316 , which in this example includes foil, may be applied to base  8336  to contain and seal the desiccant  8315  against the intrusion of moisture and other contamination, and may also provide evidence of tampering. 
     In some embodiments, the seal  8316  may comprise only a single protective layer applied to the cap  8330 , such as foil. In some embodiments, the seal  8316  may comprise two or more layers of different materials. The first layer may be made of a synthetic material (e.g., a flash-spun high-density polyethylene fiber), such as Tyvek® available from DuPont®. Tyvek® is highly durable and puncture resistant and allows the permeation of vapors. The Tyvek® layer can be applied before a gaseous chemical sterilization is performed, and following the gaseous chemical sterilization, a foil or other vapor and moisture resistant material layer may be sealed (e.g., heat sealed) over the Tyvek® layer to prevent the ingress of contaminants and moisture. 
     Referring now to  FIG.  84   , illustrated is an enlarged cross-sectional side view of the sensor control device assembly  8310  having sensor control device  8102  mounted within the sensor applicator  8312  and the cap  8330  secured thereto, according to one or more embodiments. The sensor control device  8102  may be loaded into the sensor applicator  8312  by mating the sharp hub  8230  with the sharp carrier  8360  and by mating the electronics housing  8104  of the sensor control device  8102  with the sensor carrier  8364  (alternately referred to as a “puck carrier”). More specifically, the hub small cylinder  8238  and the hub snap pawl  8240  of sharp hub  8230  may be received by corresponding mating features of the sharp carrier  8360 . 
     After installation in sensor control device assembly  8310 , the sensor control device  8102  may be subjected to “focused” radiation sterilization  8404 , where the radiation is applied and otherwise directed toward the sensor  8110  and the sharp  8116 . In such embodiments, some or all of the electrical components  8204  ( FIG.  82   ), such as components group  8406  indicated with a dashed enclosure in  FIG.  84   , may be positioned out of the range (span) of the propagating radiation  8404  and, therefore, will not be affected by the radiation. For this purpose, apertures  8208   a ,  8208   b ,  8208   c ,  8208   d , sensor  8110 , and sharp module  8112  are spaced apart from the sensor central axis  8105  to increase the distance between these features that receive radiation  8404  and the components group  8406  of PCB  8202  that may contain various of the components  8204 ,  8206  that are to be protected from radiation  8404 . For example, some or all of the electrical components  8204  and the data processing unit  8206 , as examples, may be positioned on the PCB  8202  near its outer periphery so as not to fall within the range (span) of the focused radiation sterilization  8404 . In other embodiments, this protection from radiation may be accomplished by shielding some or all of the electrical components  8204  and the data processing unit  8206 , as examples, with proper electromagnetic shields. 
     As indicated above, portions of the sensor  8110  and the sharp  8116  may be arranged within the sealed region  8370  and thereby protected from substances that might adversely interact with the chemistry of the sensor  8110 . More specifically, the sealed region  8370  protects the tail  8216 . The sealed region  8370  may include (encompass) select portions of the interior of the electronics housing  8104  and the post chamber  8356  of the post  8350 . In one or more embodiments, the sealed region  8370  may be defined and otherwise formed by at least a first seal  8408   a  and a second seal  8408   b . Coupling the shell  8106  to the mount  8108  may create a sealed interface therebetween that may also participate in defining the extent of sealed region  8370 . 
     The first seal  8408   a  may be arranged to seal an interface between the sharp hub  8230  and the shell  8106 . In the present example, the first seal  8408   a  may be arranged to seal a first interface  8411  between the sensor carrier  8364  and the top of the electronics housing  8104 , e.g., the shell  8106 . The first seal  8408   a  may also be arranged to seal a second interface  8412  between the sensor carrier  8364  and sharp hub  8230  of the sharp module  8112 . Moreover, at first interface  8411  the first seal  8408   a  may circumscribe the first central aperture  8208   a  defined in the shell  8106  such that contaminants are prevented from migrating in a radial direction (relative to sensor axis  8105 ) into the interior of the electronics housing  8104  via the first central aperture  8208   a  or channel  8210 . At second interface  8412  the first seal  8408   a  may prevent fluid from migrating in an axial direction relative to assembly axis  8311  (or, alternatively, relative to sensor axis  8105 ) into the interior of the electronics housing  8104  via the first central aperture  8208   a  or channel  8210 . Therefore, the first seal  8408   a  interposes the sensor carrier  8364  and the electronics housing  8104  and interposes sensor carrier  8364  and the sharp hub  1039  and is configured to provide axial and radial sealing. In this example, first seal  8408   a  is interposed between sensor applicator  8312  (e.g., the sensor carrier  8364 ) and sensor control device  8104  and is also interposed between sensor applicator  8312  and sharp module  8112 . 
     In at least one embodiment, the first seal  8408   a  may be overmolded on to the sensor carrier  8364 , thus forming a part of sensor carrier  8364 . In other embodiments, however, the first seal  8408   a  may form part of the sharp hub  8230 , such as by being overmolded onto the sharp hub  8230 . In yet other embodiments, the first seal  8408   a  may be overmolded onto the top surface of the shell  8106 . In even further embodiments, the first seal  8408   a  may comprise a separate structure, such as an O-ring or the like, that interposes the sharp hub  8230  and the top surface of the shell  8106 , without departing from the scope of the disclosure. 
     The second seal  8408   b  may be arranged to seal an interface  8413  between the post  8350  and the bottom of the mount  8108 , and the second seal  8408   b  may circumscribe the second central aperture  8208   b  defined in the mount  8108 . The second seal  8408   b  may also circumscribe the post chamber  8356 . Consequently, the second seal  8408   b  may prevent contaminants from migrating into the post chamber  8356  of the post  8350  and also from migrating into the interior of the electronics housing  8104  via the second central aperture  8208   b . For clarity, interface  8413  may also be referred to as a third interface. At third interface  8413 , the second seal  8408   b  may prevent fluid from migrating in the radial direction. 
     As illustrated in  FIG.  84   , the housing support  8250 , which in this example is a collar  8250 , may be located in electronics housing  8104  in the vicinity of apertures  8208   a ,  8208   b ,  8208   c ,  8208   d  and around collar  8250  of mount  8108  to provide support between shell  8106  and mount  8108  when an axial force is applied to engage seals  8408   a ,  8408   b  with electronics housing  8104 . The collar  8250  extends between the top and bottom of the electronics housing  8104  (e.g. shell  8106  and mount  8108 , respectively) and is positioned about the sensor  8110  to support the top of the electronics housing  8104  against flexing toward the bottom of the electronics housing and to support the bottom of the electronics housing against flexing toward the top of the electronics housing. Thus, collar  8250  is configured to provide a reaction force between top and bottom of the electronics housing  8104  when seals  8408   a ,  8408   b  engage electronics housing  8104 . Some embodiments include a housing support  8250  that is formed or bonded as a portion of electronics housing  8104  and may be, as examples, an extension of shell  8106  or an extension of mount  8108 . 
     Upon loading the sensor control device  8102  into the sensor applicator  8312  and securing the cap  8330  to the sensor applicator  8312 , the first and second seals  8408   a,b  become compressed and generate corresponding sealed interfaces. The first and second seals  8408   a,b  may be made of a variety of materials capable of generating a sealed interface between opposing structures. Suitable materials include, but are not limited to, silicone, a thermoplastic elastomer (TPE), polytetrafluoroethylene (Teflon®), rubber, an elastomer, or any combination thereof. 
     The cap  8330  may be secured to the sensor applicator  8312  by threading the cap  8330  to the sensor applicator  8312  via relative rotation. As the cap  8330  rotates relative to the sensor applicator  8312 , the post  8350  advances axially until post  8350  or the inner shell  8340  of cap  8330  engages the second seal  8408   b  on the sealable surface  8418  at the bottom of the mount  8108 , creating a sealed interface  8413  therebetween. As the electronics housing  8104  of sensor control device  8102  is urged to rotate through frictional engagement between the second seal  8408   b  and post  8350  or the inner shell  8340  of cap  8330 , sensor carrier  8364  inhibits rotation of the sensor control device  8102 . 
       FIG.  85    shows a bottom view of sensor control device  8102  and sensor carrier  8364 . Sensor carrier  8364  includes a pair of arms  8506  that extend around sensor control device  8102 . Arms  8506  may grasp notches formed in electronic housing  8106 . As illustrated, a sealable surface  8418  that extends around second central aperture  8208   b  may be defined on the bottom of the mount  8108 . The sealable surface  8418  may comprise a groove. The sealable surface  8418  may receive second seal  8408   b  to isolate (protect) the tail  8216  of the sensor  8110  from environmental contamination or from potentially harmful sterilization gases when gaseous chemical sterilization is used. In the illustrated embodiment, the second seal  8408   b  is overmolded onto the bottom of the mount  8108  within a groove of sealable surface  8418 . Thus, second seal  8408   b  forms a part of the electronics housing  8104 . In other embodiments, however, the second seal  8408   b  may form part of the post  8350  ( FIG.  84   ). For example, the second seal  8408   b  may be overmolded onto the top of the post  8350 . In yet other embodiments, the second seal  8408   b  may comprise a separate structure, such as an O-ring or the like, that interposes the post  8350  and the bottom of the mount  8108 , without departing from the scope of the disclosure. 
       FIG.  86    is a schematic diagram of an example sterilization assembly  8600 , according to one or more embodiments of the present disclosure. The sterilization assembly  8600  (hereafter the “assembly  8600 ”) may be designed and otherwise configured to help sterilize a medical device  8602  that may be deployed for use from a sensor applicator  8604 . The medical device  8602  may comprise, for example, a sensor control device similar in some respects to any of the sensor control devices described herein. In such embodiments, the sensor applicator  8604  may be similar in some respects to any of the sensor applicators described herein. Alternatively, the medical device  8602  may comprise other types of medical devices, health care products, or systems requiring terminal sterilization of specific component parts. Example medical devices or health care products that may incorporate the principles of the present disclosure include, but are not limited to, ingestible products, cardiac rhythm management (CRM) devices, under-skin sensing devices, externally mounted medical devices, or any combination thereof. 
     As illustrated, the medical device  8602  may include a housing  8606 , a part  8608  requiring sterilization, and one or more radiation sensitive components  8610 . In the illustrated embodiment, the radiation sensitive component  8610  may be mounted to a printed circuit board (PCB)  8612  positioned within the housing  8606  and may include one or more electronic modules such as, but not limited to, a data processing unit (e.g., an application specific integrated circuit or ASIC), a resistor, a transistor, a capacitor, an inductor, a diode, and a switch. 
     As illustrated, the part  8608  may extend at an angle relative to the housing  8606 , but could alternatively extend perpendicular to the housing  8606 . In some embodiments, the part  8608  may comprise a sensor (e.g., the sensor  8110  of  FIGS.  81 A- 81 B ) and a sharp (e.g., the sharp  8116  of  FIGS.  81 A- 81 B ) used to help implant the sensor beneath the skin of a user. In some embodiments, as illustrated, the part  8608  may be temporarily encapsulated within a sterile chamber  8614  that provides a sealed barrier to protect exposed portions of the part  8608  (e.g., the sensor and associated sharp) until the part  8608  is needed for use. 
     The medical device  8602  may be subjected to radiation sterilization  8616  to properly sterilize the part  8608  for use. Suitable radiation sterilization  8616  processes include, but are not limited to, electron beam (e-beam) irradiation, gamma ray irradiation, X-ray irradiation, or any combination thereof. As illustrated, the assembly  8600  may include a radiation shield  8618  positioned external to the medical device  8602  and configured to help sterilize the part  8608  while preventing (impeding) propagating radiation  8616  from disrupting or damaging the radiation sensitive components  8610 . To accomplish this, the radiation shield  8618  may provide a collimator  8620  that generally comprises a hole or passageway extending at least partially through the body of the radiation shield  8618 . The collimator  8620  provides a sterilization zone designed to direct (focus) the radiation  8616  toward the part  8608 . 
     While the collimator  8610  focuses the radiation  8616  (e.g., beams, waves, energy, etc.) toward the part  8608 , the remaining portions of the radiation shield  8618  may be made of a material that reduces or eliminates the radiation  8616  from penetrating therethrough and thereby damaging the radiation sensitive components  8610  within the housing  8606 . In other words, the radiation shield  8618  may be made of a material having a density sufficient to absorb the dose of the beam energy being delivered. In some embodiments, for example, the radiation shield  8618  may be made of any material that has a mass density greater than 0.9 grams per cubic centimeter (g/cc). In other embodiments, however, the mass density of a suitable material may be less than 0.9 g/cc, without departing from the scope of the disclosure. Suitable materials for the radiation shield  8618  include, but are not limited to, a high-density polymer, (e.g., polyethylene, polypropylene, polystyrene, polytetrafluoroethylene, etc.), a metal (e.g., lead, stainless steel, aluminum, etc.), any combination thereof, or any material having a mass density greater than 0.9 g/cc. 
     The collimator  8620  can exhibit any suitable cross-sectional shape necessary to focus the radiation on the part  8608  for sterilization. In the illustrated embodiment, for example, the collimator  8620  has a circular cross-section with parallel sides. In other embodiments, however, the collimator  8620  may have a polygonal cross-sectional shape, such as cubic or rectangular (e.g., including parallelogram), without departing from the scope of the disclosure. 
     In some embodiments, the assembly  8600  may further include a barrier shield  8622  positioned within the housing  8606 . The barrier shield  8622  may be configured to help block radiation  8616  (e.g., electrons) from propagating within the housing  8606  toward the radiation sensitive components  8610 . The barrier shield  8622  may be made of any of the materials mentioned above for the radiation shield  8618 . In the illustrated embodiment, the barrier shield  8622  is positioned vertically within the housing  8606 , but may alternatively be positioned at any other angular configuration suitable for protecting the radiation sensitive components  8610 . 
     In some embodiments, the sterile chamber  8614  may comprise a cap that encapsulates the part  8608  to provide a sealed barrier that protects exposed portions of the part  8608  until the part  8608  is placed in use. In such embodiments, the sterile chamber  8614  may be removable or detachable to expose the part  8608 , as described below. Moreover, in such embodiments, the cap may be made of a material that allows radiation to propagate therethrough to allow sterilization of the part  8608 . Suitable materials for the sterile chamber  8614  include, but are not limited to, a non-magnetic metal (e.g., aluminum, copper, gold, silver, etc.), a thermoplastic, ceramic, rubber (e.g., ebonite), a composite material (e.g., fiberglass, carbon fiber reinforced polymer, etc.), an epoxy, or any combination thereof. In some embodiments, the sterile chamber  8614  may be transparent or translucent, but can otherwise be opaque, without departing from the scope of the disclosure. 
     In other embodiments, the sterile chamber  8614  may comprise a chamber or compartment defined within one or both of the sensor applicator  8604  and the sensor control device  8602 . In such embodiments, the sterile chamber  8614  may include a microbial barrier positioned at one or both ends of the sterile chamber  8614 . More specifically, the sterile chamber  8614  may provide or include an upper microbial barrier  8624   a  and a lower microbial barrier  8624   b  opposite the upper microbial barrier  8624   a . The upper and lower microbial barriers  8624   a,b  may help seal the sterile chamber  8614  to thereby isolate the part  8608  from external contamination. The microbial barriers  8624   a,b  may be made of a radiation permeable material, such as a synthetic material (e.g., a flash-spun high-density polyethylene fiber). One example synthetic material comprises TYVEK®, available from DuPont®. In other embodiments, however, the microbial barriers  8624   a,b  may comprise, but are not limited to, tape, paper, film, foil, or any combination thereof. 
     In embodiments where the sterile chamber  8614  comprises a cap, the sterile chamber  8614  may be movable distally to help facilitate the sterilization process. More specifically, the sterile chamber  8614  may be movable at least partially into the sterilization zone formed by the collimator  8620 . Once positioned within the sterilization zone, the part  8608  may be subjected to the radiation  8616  to sterilize the part  8608  for use. Once sterilization is done, the sterile chamber  8614  may be retracted proximally in preparation for firing the sensor control device  8602 . Distally advancing the sterile chamber  8614  may be accomplished via a variety of mechanical or electromechancial means. In some embodiments, for example, the sensor applicator  8604  may include a plunger  8626  configured to advance distally to push the sterile chamber  8614  distally, and subsequently retract the sterile chamber  8614  once the sterilization process is complete. 
     The part  8608  itself may also be deployable and otherwise movable relative to the sensor applicator  8604 . More particularly, the part  8608  may be advanced distally past the bottom of the electronics housing  8606  to allow the part  8608  to be transcutaneously received beneath a user&#39;s skin. In some embodiments, the plunger  8626  may be used to push the part  8608  out of the sterile chamber  8614 . In such embodiments, the plunger  8626  may also be configured to attach to a portion of the part  8608  (e.g., the sharp) and subsequently retract that portion of the part  8608  while leaving another portion of the part  8608  (e.g., the sensor) extended. Moreover, in such embodiments, the plunger  8626  may be configured to penetrate the upper microbial barrier  8624   a  and force the part  8608  distally through the lower microbial barrier  8624   b.    
     In other embodiments, the part  8608  may be advanced distally out of the sterile chamber  8614  using a magnetic coupling. More specifically, the sensor applicator  8604  may include a driver magnet  8628  movable within the sensor applicator  8604  and magnetically coupled to a driven magnet  8630  disposed on the part  8608 , such as on an upper end of the sharp. The driver magnet  8628  may be configured to advance distally and simultaneously push the part  8608  out of the sterile chamber  8614  as magnetically coupled to the driven magnet  8630 . In such embodiments, actuation of the magnetic coupling may force the part  8608  distally through the lower microbial barrier  8624   b . Once the sensor is properly placed, the driver magnet  8628  may be retracted proximally and simultaneously retract the sharp in the same direction while leaving the sensor extended. 
     In embodiments where the sterile chamber  8614  comprises a cap, the plunger  8626  may also be operable to discharge or push the cap out of the sensor applicator  8604  to enable the part  8608  to be properly received by the user. In such embodiments, a user may commence the firing process by priming the sensor applicator  8604 , which may cause the cap to be discharged or ejected from the sensor applicator  8604 . Further actuation of the sensor applicator  8604  by the user may cause the part  8608  to be fully extended for subcutaneous implantation. In other embodiments, however, the cap may be removed either autonomously (e.g., it falls off or breaks away) or the user may manually remove it by hand. 
     In some embodiments, the sensor applicator  8604  may further include an electrical connector  8632  in electrical communication with the electronics of the sensor control device  8602 , such as the radiation sensitive component  8610 . In at least one embodiment, the electrical connector  8632  may comprise one or more elastic pins made of a conductive polymer (e.g., a carbon impregnated polymer) and configured to facilitate electrical communication between the sensor and the radiation sensitive component  8610 . In such embodiments, the sensor may include one or more connectors  8634  alignable with the electrical connector  8632  when the part  8608  is advanced distally, as described above. Moreover, in embodiments where the sterile chamber  8614  comprises a cap, the electrical connector  8632  may be flexible to allow the cap to pass by the electrical connector  8632  until the connectors  8634  align with the electrical connector  8632 . 
       FIG.  87    is a schematic diagram of another example sterilization assembly  8700 , according to one or more embodiments of the present disclosure. The sterilization assembly  8700  (hereafter the “assembly  8700 ”) may be similar in some respects to the assembly  8600  of  FIG.  86    and therefore may be best understood with reference thereto, where like numerals will represent like components not described again in detail. Similar to the assembly  8600 , for example, the medical device  8602  may be arranged for deployment within the sensor applicator  8604 , and the part  8608  requiring sterilization may be temporarily encapsulated within the sterile chamber  8614 . Unlike the assembly  8600 , however, the part  8608  may be subjected to the radiation sterilization  8616  through the body of the sensor applicator  8604 . 
     More specifically, the radiation sterilization  8616  may be directed to the top of the sensor applicator  8604 , which defines a collimator  8702  that allows the radiation  8616  to impinge upon and sterilize the part  8608 . As illustrated, the collimator  8702  generally comprises a hole or passageway extending through the body of the sensor applicator  8604 . The collimator  8702  focuses (guides) the radiation  8616  toward the part  8608  and can exhibit any suitable cross-sectional shape necessary to focus the radiation  8616  on the part  8608  for sterilization. In the illustrated embodiment, for example, the collimator  8702  has a circular cross-section with parallel sides, but may alternatively exhibit a polygonal cross-sectional shape, such as cubic or rectangular (e.g., including parallelogram), without departing from the scope of the disclosure. 
     The sensor applicator  8604  may also act as a radiation shield that helps prevent (impede) propagating radiation  8616  from disrupting or damaging the radiation sensitive components  8610 , except through the collimator  8702 . To accomplish this, the sensor applicator  8604  may be made of a material similar to the material of the radiation shield  8618  of  FIG.  86   . In at least one embodiment, however, the radiation sterilization  8616  may be emitted from a device or machine configured to focus and/or aim the radiation  8616  directly into the collimator  8702 , and thereby mitigating radiation  8616  exposure to adjacent portions of the sensor applicator  8604 . 
     In some embodiments, a seal  8704  may be arranged at the opening to the collimator  8702  at the top of the sensor applicator  8604 . The seal  8704  may comprise a radiation permeable, microbial barrier, similar to the microbial barriers  8624   a,b  of  FIG.  86   . The seal  8704  may seal off the collimator  8702 , while simultaneously allowing the radiation  8616  to pass therethrough to sterilize the part  8608 . 
     In at least one embodiment, the position of the radiation sensitive components  8610  may be moved away from the line of fire of the radiation  8616 . In other embodiments, the barrier shield  8622  may extend about at least two sides of the radiation sensitive components  8610  to ensure sufficient blockage of the radiation  8616 . In at least one embodiment, however, the barrier shield  8622  may fully encapsulate the radiation sensitive components  8610 . 
     In one embodiment, the radiation sterilization  8616  may be directed toward the part  8608  from the bottom of the sensor control device  8602  and the bottom of the sensor applicator  8604 . In such embodiments, a shield  8706  may be positioned at the bottom of one or both of the sensor control device  8602  and the bottom of the sensor applicator  8604 . The shield  8706  may be made of any of the materials mentioned above for the radiation shield  8618  of  FIG.  86   . Consequently, the shield  8706  may be configured to help block the radiation  8616  (e.g., electrons) from propagating toward the radiation sensitive components  8610 . The shield  8706 , however, may define or otherwise provide an aperture  8708  aligned with the part  8608  to allow the radiation  8616  to impinge upon the part  8608  for proper sterilization. 
     In at least one embodiment, the shield  8706  may form part of the sensor control device  8602  and may be deployed simultaneously with the sensor control device  8602  from the sensor applicator  8604 . In some embodiments, the shield  8706  may be removable from the sensor control device  8602  and otherwise only used during the sterilization process. In other embodiments, the shield  8706  may be arranged within the housing  8606  and otherwise form an integral part thereof, without departing from the scope of the disclosure. 
       FIG.  88 A  is a schematic bottom view of another example sterilization assembly  8800 , according to one or more embodiments of the present disclosure. The sterilization assembly  8800  (hereafter the “assembly  8800 ”) may be used to sterilize a medical device  8802 , which may comprise a sensor control device or any of the other types of medical devices mentioned herein. In the illustrated embodiment, the medical device  8802  comprises a sensor control device having a housing  8804  that defines an aperture  8806  through which a part  8808  requiring sterilization may extend. In the view of  FIG.  88 A , the part  8808  extends through the aperture  8806  and out of the page. Moreover, the part  8808  may comprise one or both of a sensor and a sharp, as generally described herein. The medical device  8802  may also include a battery  8810  and a radiation sensitive component  8812  arranged within the housing  8804 . The battery  8810  may power the medical device  8802  and the radiation sensitive component  8812  may be similar to the radiation sensitive component  8610  of  FIGS.  86  and  87   . 
     As illustrated, the housing  8804  may exhibit a generally polygonal cross-sectional shape. More specifically, the housing  8804  is generally triangular with rounded corners. The position of the radiation sensitive component  8812  relative to the part  8808  is effectively as far away as possible within the confines of the housing  8804 . As will be appreciated, this may help reduce the chances of the radiation sensitive component  8812  being damaged during a radiation sterilization process to sterilize the part  8808 . 
     The assembly  8800  may also include a shield  8814  (shown in dashed lines), which may be made of the materials mentioned above for the radiation shield  8618  of  FIG.  86   . Consequently, the shield  8814  may be configured to help protect the radiation sensitive component  8812  from damaging radiation during a sterilization process. In one embodiment, the shield  8814  may be arranged external to the housing  8804  and otherwise arranged to interpose the radiation sensitive component  8812  and the propagating electrons from the radiation treatment. In other embodiments, however, the shield  8814  may be arranged within the housing  8804  and otherwise form part of the medical device  8802 , without departing from the scope of the disclosure. 
       FIGS.  88 B and  88 C  are schematic bottom views of alternative embodiments of the sterilization assembly  8800  of  FIG.  88 A , according to one or more additional embodiments of the present disclosure. In  FIG.  88 B , the housing  8804  exhibits a generally circular shape, and in FIG.  88 C, the housing  8804  exhibits a generally oval or ovoid shape. As will be appreciated, the housing  8804  may alternatively exhibit other cross-sectional shapes, including additional polygonal shapes (e.g., square, rectangular, pentagonal, etc.), without departing from the scope of the disclosure. 
     In  FIGS.  88 B and  88 C , the part  8808  extends through the aperture  8806  and out of the page. Moreover, the battery  8810  and the radiation sensitive component  8812  may be arranged within the housing  8804  and the radiation sensitive component  8812  may be positioned relative to the part  8808  as far away as possible within the confines of the housing  8804 . Again, this may help reduce the chances of the radiation sensitive component  8812  being damaged during a radiation sterilization process to sterilize the part  8808 . The shield  8814  (shown in dashed lines) may again be included and configured to help protect the radiation sensitive component  8812  from damaging radiation during a sterilization process. As illustrated, the shield  8814  may be arranged external to the housing  8804 , or alternatively within the housing  8804  and otherwise form part of the medical device  8802 , without departing from the scope of the disclosure. 
       FIG.  89    is an isometric schematic view of an example sensor control device  8900 , according to one or more embodiments. The sensor control device  8900  may be similar in some respects to the sensor control devices described herein and, therefore, may be used as an on-body monitoring device used to monitor blood glucose levels. As illustrated, the sensor control device  8900  includes a housing  8902  that may contain and otherwise housing electronics used to operate the sensor control device  8900 . In the illustrated embodiment, the housing  8902  is generally disc-shaped and with a circular cross-section, but could alternatively exhibit other cross-sectional shapes, such as ovoid or polygonal and may be non-symmetrical. While not shown, an adhesive patch may be attached to the bottom of the housing  8902  to help attach the sensor control device  8900  to the skin of a user at a target monitoring location. 
     The sensor control device  8900  may further include a sensor  8904  and a sharp  8906  extending distally from the bottom of the housing  8902 . The sensor  8904  and the sharp  8906  may be similar in some respects to the sensor  8110  and the sharp  8116  of  FIGS.  81 A- 81 B . Accordingly, in some embodiments, the sharp  8906  may be used to help deliver the sensor  8904  transcutaneously under a user&#39;s skin during application of the sensor control device  8900 . The exposed portion of the sensor  8904  may be received within a hollow or recessed portion of the sharp  8906 , and the remaining portion(s) of the sensor  8904  is/are positioned within the interior of the electronics housing  8902 . 
     In some embodiments, the sharp  8906  may be made of a dermal-dissolving material. In such embodiments, the sharp  8906  may be used to help introduce the sensor  8904  into the user&#39;s skin, but may dissolve after a predetermined time period upon exposure to chemicals and/or substances commonly found in the human body. Consequently, in such embodiments, there is no need to retract the sharp  8906 . Rather, the sharp  8906  may remain embedded within the user&#39;s dermal layer until it safely dissolves. A dermal-dissolving sharp  8906  may also make sterilization applications much easier, since low-energy surface sterilization may only be needed. 
     In other embodiments, the sharp  8906  may be omitted from the sensor control device  8900 . In such embodiments, the sensor  8904  may be made of materials that are rigid enough to allow the sensor  8904  to be transcutaneously received beneath a user&#39;s skin for monitoring without the assistance of the sharp  8906 . Accordingly, the sensor  8906  may operate as both a sensor and a sharp or introducer. Such embodiments may prove advantageous in eliminating the mechanisms and assemblies typically required to retract the sharp  8906 . 
     As will be appreciated, any of the embodiments mentioned herein may incorporate a dermal dissolving sharp or introducer, or may alternatively include a sharp that operates as both a sensor and a sharp, without departing from the scope of the disclosure. 
       FIG.  90    is a schematic diagram of another example sterilization assembly  9000 , according to one or more embodiments. Similar to the other sterilization assemblies described herein, the sterilization assembly  9000  (hereafter the “assembly  9000 ”) may be used to help sterilize a medical device, such as a sensor control device  9002 . The sensor control device  9002  may be similar in some respects to some or all of the sensor control devices described herein. For example, the sensor control device  9002  includes a housing  9004  that may contain and otherwise house the electronics used to operate the sensor control device  9002 . The sensor control device  9002  may further include a part  9005  requiring sterilization, one or more radiation sensitive components  9006 , and a battery  9008  that powers the sensor control device  9002 . The radiation sensitive component  9006  may be arranged within the housing  9004  and may include one or more electronic modules such as, but not limited to, a data processing unit (e.g., an application specific integrated circuit or ASIC), a resistor, a transistor, a capacitor, an inductor, a diode, and a switch. 
     As illustrated, the part  9005  may extend perpendicularly from the bottom of the housing  9004 , but could alternatively extend at an angle relative to the housing  9004 . Moreover, while the part  9005  extends generally concentric with a centerline of the housing  9004 , the part  9005  could alternatively extend from the housing  9004  at a location eccentric to the centerline, without departing from the scope of the disclosure. In some embodiments, the part  9005  may comprise a sensor (e.g., the sensor  8110  of  FIGS.  81 A- 81 B ) and a sharp (e.g., the sharp  8116  of  FIGS.  81 A- 81 B ) used to help implant the sensor beneath the skin of a user. 
     The medical device  8602  may be subjected to radiation sterilization  9010  to properly sterilize the part  9005  for use. Suitable radiation sterilization  9010  processes include, but are not limited to, electron beam (e-beam) irradiation, gamma ray irradiation, X-ray irradiation, or any combination thereof. To help guide and otherwise focus the radiation  9010  toward the part  9005  and simultaneously away from the radiation sensitive component  9006 , the assembly  9000  may include or otherwise employ one or more magnets configured to direct the electrons of the radiation  9010  in a predetermined sterilization path. 
     More particularly, as illustrated, the assembly  9000  may include a central magnet  9012  and opposing lateral magnets  9014   a  and  9014   b . The central magnet  9012  may be arranged opposite a radiation source  9016  such that the part  9005  to be sterilized interposes the central magnet  9012  and the radiation source  9016 . The central magnet  9012  may be tuned and otherwise configured to draw the electrons of the radiation  9010  toward the central magnet  9012 , which generally urges the radiation  9010  toward the center of the sensor control device  9002  and otherwise to where the part  9005  is located. In addition, the lateral magnets  9014   a,b  may be arranged on opposite sides of the sensor control device  9002  and tuned or otherwise configured to generate a magnetic field that pushes the electrons of the radiation  9010  toward the center of the sensor control device  9002  or otherwise to where the part  9005  is located. Accordingly, the central and lateral magnets  9012 ,  9014   a,b  may cooperatively urge the radiation  9010  away from the radiation sensitive components  9006  and instead toward the part  9005  to sterilize the part  9005 . 
     Embodiments disclosed herein include: 
     Z. A sensor control device assembly that includes a sensor applicator, a sensor control device positioned within the sensor applicator and including an electronics housing, a sensor extending from a bottom of the electronics housing, a sharp hub positioned adjacent a top of the electronics housing, and a sharp carried by the sharp hub and extending through the electronics housing and from the bottom of the electronics housing, a cap removably coupled to the sensor applicator and providing a support structure that defines a post chamber that receives the sensor and the sharp extending from the bottom of the electronics housing, a first seal that provides a radial seal against the sharp hub and an axial seal against the top of the electronics housing, and a second seal that seals an interface between the post and the bottom of the electronics housing. 
     AA. A method including positioning a sensor control device within a sensor applicator, the sensor control device including an electronics housing, a sensor extending from a bottom of the electronics housing, a sharp hub positioned adjacent a top of the electronics housing, and a sharp carried by the sharp hub and extending through the electronics housing and from the bottom of the electronics housing, removably coupling a cap to the sensor applicator, the cap providing a support structure that defines a post chamber that receives the sensor and the sharp extending from the bottom of the electronics housing, providing a radial seal against the sharp hub with a first seal, providing an axial seal against the top of the electronics housing with the first seal, and sealing an interface between the post and the bottom of the electronics housing with a second seal. 
     BB. A sensor control device assembly includes a sensor applicator, a sensor control device positioned within the sensor applicator and including an electronics housing having a top and a bottom, a sensor coupled to the electronics housing, and a sharp module engageable with the electronics housing and having a sharp. The sensor control device assembly further includes a post having a first end positioned proximal the bottom of the electronics housing, a second end opposite the first end, and a post chamber extending between the first and second ends, wherein distal portions of the sensor and the sharp are receivable within the post chamber, a first seal interposing the sensor applicator and the electronics housing to seal an interface therebetween and interposing the sensor applicator and the sharp module to seal an interface therebetween, and a second seal interposing the first end of the post and the bottom of the electronics housing. 
     Each of embodiments Z, AA, and BB may have one or more of the following additional elements in any combination: Element 1: further comprising a sensor carrier arranged within the sensor applicator to secure the sensor control device, wherein the first seal is overmolded onto the sensor carrier. Element 2: wherein the cap comprises a first end threaded to the sensor applicator, and a second end opposite the first end, and wherein the support structure extends from the second end into the sensor applicator and toward the sensor control device. Element 3: wherein the first seal circumscribes a top aperture defined in the electronics housing and prevents contaminants from migrating into an interior of the electronics housing via the top aperture. Element 4: wherein the second seal circumscribes a bottom aperture defined on the bottom of the electronics housing and prevents contaminants from migrating into an interior of the electronics housing via the bottom aperture and into the post chamber. Element 5: wherein the sensor control device includes a housing support positioned within the electronics housing and extending between the top and bottom of the electronics housing and positioned about the sensor to support the top of the electronics housing against flexing toward the bottom of the electronics housing and to support the bottom of the electronics housing against flexing toward the top of the electronics housing. Element 7: wherein the sensor and the sharp are positioned eccentric from a central axis of the electronics housing. Element 8: wherein the first seal is overmolded onto the top of the electronics housing. 
     Element 9: further creating a sealed region as the cap is coupled to the sensor applicator, the sealed region encompassing the post chamber and a portion of an interior of the electronics housing, wherein portions of the sensor and the sharp reside within the sealed region. Element 10: further comprising sterilizing the sensor and the sharp with radiation sterilization while positioned within the sensor applicator. Element 11: wherein the radiation sterilization is at least one of focused radiation sterilization and low-energy radiation sterilization. Element 12: wherein the first seal is over overmolded onto a sensor carrier arranged within the sensor applicator to secure the sensor control device. Element 13: wherein removably coupling the cap to the sensor applicator comprises advancing the support structure into the sensor applicator and thereby causing the second seal to seal the interface between the post and the bottom of the electronics housing. Element 14: wherein the sensor control device includes a housing support positioned within the electronics housing and extending between the top and bottom of the electronics housing, the method further comprising supporting the top of the electronics housing against flexing toward the bottom of the electronics housing with the housing support, and supporting the bottom of the electronics housing against flexing toward the top of the electronics housing with the housing support. Element 15: further comprising preventing contaminants from migrating into an interior of the electronics housing via a top aperture defined in the electronics housing with the first seal. Element 16: further comprising preventing contaminants from migrating into the post chamber and an interior of the electronics housing via a bottom aperture defined on the bottom of the electronics housing with the second seal. 
     Element 17: further comprising a sensor carrier positioned within the sensor applicator to secure the sensor control device, wherein the first seal seals a first interface between the sensor carrier and the electronics housing and a second interface between the sensor carrier and the sharp module. Element 18: further comprising a cap removably coupled to the sensor applicator and providing a support structure that extends from the bottom of the sensor applicator toward the sensor control device, wherein the post extends from the support structure. 
     By way of non-limiting example, exemplary combinations applicable to Z, AA, and BB include: Element 10 with Element 11; and Element 13 with Element 14. 
     Seal Arrangement for Analyte Monitoring Systems 
       FIGS.  91 A and  91 B  are side and isometric views, respectively, of an example sensor control device  9102 , according to one or more embodiments of the present disclosure. The sensor control device  9102  may be similar in some respects to the sensor control device  104  of  FIG.  1    and therefore may be best understood with reference thereto. Moreover, the sensor control device  9102  may replace the sensor control device  104  of  FIG.  1    and, therefore, may be used in conjunction with the sensor applicator  102  of  FIG.  1   , which may deliver the sensor control device  9102  to a target monitoring location on a user&#39;s skin. 
     As illustrated, the sensor control device  9102  includes an electronics housing  9104 , which may be generally disc-shaped and have a circular cross-section. In other embodiments, however, the electronics housing  9104  may exhibit other cross-sectional shapes, such as ovoid, oval, or polygonal, without departing from the scope of the disclosure. The electronics housing  9104  includes a shell  9106  and a mount  9108  that is matable with the shell  9106 . The shell  9106  may be secured to the mount  9108  via a variety of ways, such as a snap fit engagement, an interference fit, sonic welding, laser welding, one or more mechanical fasteners (e.g., screws), a gasket, an adhesive, or any combination thereof. In some cases, the shell  9106  may be secured to the mount  9108  such that a sealed interface is generated therebetween. An adhesive patch  9110  may be positioned on and otherwise attached to the underside of the mount  9108 . Similar to the adhesive patch  108  of  FIG.  1   , the adhesive patch  9110  may be configured to secure and maintain the sensor control device  9102  in position on the user&#39;s skin during operation. 
     The sensor control device  9102  may further include a sensor  9112  and a sharp  9114  used to help deliver the sensor  9112  transcutaneously under a user&#39;s skin during application of the sensor control device  9102 . Corresponding portions of the sensor  9112  and the sharp  9114  extend distally from the bottom of the electronics housing  9104  (e.g., the mount  9108 ). A sharp hub  9116  may be overmolded onto the sharp  9114  and configured to secure and carry the sharp  9114 . As best seen in  FIG.  91 A , the sharp hub  9116  may include or otherwise define a mating member  9118 . In assembling the sharp  9114  to the sensor control device  9102 , the sharp  9114  may be advanced axially through the electronics housing  9104  until the sharp hub  9116  engages an upper surface of the electronics housing  9104  or an internal component thereof and the mating member  9118  extends distally from the bottom of the mount  9108 . As described herein below, in at least one embodiment, the sharp hub  9116  may sealingly engage an upper portion of a seal overmolded onto the mount  9108 . As the sharp  9114  penetrates the electronics housing  9104 , the exposed portion of the sensor  9112  may be received within a hollow or recessed (arcuate) portion of the sharp  9114 . The remaining portion of the sensor  9112  is arranged within the interior of the electronics housing  9104 . 
     The sensor control device  9102  may further include a sensor cap  9120 , shown detached from the electronics housing  9104  in  FIGS.  91 A- 91 B . The sensor cap  9120  may help provide a sealed barrier that surrounds and protects exposed portions of the sensor  9112  and the sharp  9114 . As illustrated, the sensor cap  9120  may comprise a generally cylindrical body having a first end  9122   a  and a second end  9122   b  opposite the first end  9122   a . The first end  9122   a  may be open to provide access into an inner chamber  9124  defined within the body. In contrast, the second end  9122   b  may be closed and may provide or otherwise define an engagement feature  9126 . As described in more detail below, the engagement feature  9126  may help mate the sensor cap  9120  to an applicator cap of a sensor applicator (e.g., the sensor applicator  102  of  FIG.  1   ), and may help remove the sensor cap  9120  from the sensor control device  9102  upon removing the sensor cap from the sensor applicator. 
     The sensor cap  9120  may be removably coupled to the electronics housing  9104  at or near the bottom of the mount  9108 . More specifically, the sensor cap  9120  may be removably coupled to the mating member  9118 , which extends distally from the bottom of the mount  9108 . In at least one embodiment, for example, the mating member  9118  may define a set of external threads  9128   a  ( FIG.  91 A ) matable with a set of internal threads  9128   b  ( FIG.  91 B ) defined within the inner chamber  9124  of the sensor cap  9120 . In some embodiments, the external and internal threads  9128   a,b  may comprise a flat thread design (e.g., lack of helical curvature), but may alternatively comprise a helical threaded engagement. Accordingly, in at least one embodiment, the sensor cap  9120  may be threadably coupled to the sensor control device  9102  at the mating member  9118  of the sharp hub  9116 . In other embodiments, the sensor cap  9120  may be removably coupled to the mating member  9118  via other types of engagements including, but not limited to, an interference or friction fit, or a frangible member or substance (e.g., wax, an adhesive, etc.) that may be broken with minimal separation force (e.g., axial or rotational force). 
     In some embodiments, the sensor cap  9120  may comprise a monolithic (singular) structure extending between the first and second ends  9122   a,b . In other embodiments, however, the sensor cap  9120  may comprise two or more component parts. In the illustrated embodiment, for example, the body of the sensor cap  9120  may include a desiccant cap  9130  arranged at the second end  9122   b . The desiccant cap  9130  may house or comprise a desiccant to help maintain preferred humidity levels within the inner chamber  9124 . Moreover, the desiccant cap  9130  may also define or otherwise provide the engagement feature  9126  of the sensor cap  9120 . In at least one embodiment, the desiccant cap  9130  may comprise an elastomeric plug inserted into the bottom end of the sensor cap  9120 . 
       FIGS.  92 A and  92 B  are exploded, isometric top and bottom views, respectively, of the sensor control device  9102 , according to one or more embodiments. The shell  9106  and the mount  9108  operate as opposing clamshell halves that enclose or otherwise substantially encapsulate various electronic components (not shown) of the sensor control device  9102 . Example electronic components that may be arranged between the shell  9106  and the mount  9108  include, but are not limited to, a battery, resistors, transistors, capacitors, inductors, diodes, and switches. 
     The shell  9106  may define a first aperture  9202   a  and the mount  9108  may define a second aperture  9202   b , and the apertures  9202   a,b  may align when the shell  9106  is properly mounted to the mount  9108 . As best seen in  FIG.  92 A , the mount  9108  may provide or otherwise define a pedestal  9204  that protrudes from the inner surface of the mount  9108  at the second aperture  9202   b . The pedestal  9204  may define at least a portion of the second aperture  9202   b . Moreover, a channel  9206  may be defined on the inner surface of the mount  9108  and may circumscribe the pedestal  9202 . In the illustrated embodiment, the channel  9206  is circular in shape, but could alternatively be another shape, such as oval, ovoid, or polygonal. 
     The mount  9108  may comprise a molded part made of a rigid material, such as plastic or metal. In some embodiments, a seal  9208  may be overmolded onto the mount  9108  and may be made of an elastomer, rubber, a -polymer, or another pliable material suitable for facilitating a sealed interface. In embodiments where the mount  9108  is made of a plastic, the mount  9108  may be molded in a first “shot” of injection molding, and the seal  9208  may be overmolded onto the mount  9108  in a second “shot” of injection molding. Accordingly, the mount  9108  may be referred to or otherwise characterized as a “two-shot mount.” 
     In the illustrated embodiment, the seal  9208  may be overmolded onto the mount  9108  at the pedestal  9204  and also on the bottom of the mount  9108 . More specifically, the seal  9208  may define or otherwise provide a first seal element  9210   a  overmolded onto the pedestal  9204 , and a second seal element  9210   b  ( FIG.  92 B ) interconnected to (with) the first seal element  9210   a  and overmolded onto the mount  9108  at the bottom of the mount  9108 . In some embodiments, one or both of the seal elements  9210   a,b  may help form corresponding portions (sections) of the second aperture  9202   b . While the seal  9208  is described herein as being overmolded onto the mount  9108 , it is also contemplated herein that one or both of the seal elements  9210   a,b  may comprise an elastomeric component part independent of the mount  9208 , such as an O-ring or a gasket. 
     The sensor control device  9102  may further include a collar  9212 , which may be a generally annular structure that defines a central aperture  9214 . The central aperture  9214  may be sized to receive the first seal element  9210   a  and may align with both the first and second apertures  9202   a,b  when the sensor control device  9102  is properly assembled. The shape of the central aperture  9214  may generally match the shape of the second aperture  9202   b  and the first seal element  9210   a.    
     In some embodiments, the collar  9212  may define or otherwise provide an annular lip  9216  on its bottom surface. The annular lip  9216  may be sized and otherwise configured to mate with or be received into the channel  9206  defined on the inner surface of the mount  9108 . In some embodiments, a groove  9218  may be defined on the annular lip  9216  and may be configured to accommodate or otherwise receive a portion of the sensor  9112  extending laterally within the mount  9108 . In some embodiments, the collar  9212  may further define or otherwise provide a collar channel  9220  ( FIG.  92 A ) on its upper surface sized to receive and otherwise mate with an annular ridge  9222  ( FIG.  92 B ) defined on the inner surface of the shell  9106  when the sensor control device  9102  is properly assembled. 
     The sensor  9112  may include a tail  9224  that extends through the second aperture  9202   b  defined in the mount  9108  to be transcutaneously received beneath a user&#39;s skin. The tail  9224  may have an enzyme or other chemistry included thereon to help facilitate analyte monitoring. The sharp  9114  may include a sharp tip  9226  extendable through the first aperture  9202   a  defined by the shell  9106 . As the sharp tip  9226  penetrates the electronics housing  9104 , the tail  9224  of the sensor  9112  may be received within a hollow or recessed portion of the sharp tip  9226 . The sharp tip  9226  may be configured to penetrate the skin while carrying the tail  9224  to put the active chemistry of the tail  9224  into contact with bodily fluids. 
     The sensor control device  9102  may provide a sealed subassembly that includes, among other component parts, portions of the shell  9106 , the sensor  9112 , the sharp  9114 , the seal  9208 , the collar  9212 , and the sensor cap  9120 . The sealed subassembly may help isolate the sensor  9112  and the sharp  9114  within the inner chamber  9124  ( FIG.  92 A ) of the sensor cap  9120 . In assembling the sealed subassembly, the sharp tip  9226  is advanced through the electronics housing  9104  until the sharp hub  9116  engages the seal  9208  and, more particularly, the first seal element  9210   a . The mating member  9118  provided at the bottom of the sharp hub  9116  may extend out the second aperture  9202   b  in the bottom of the mount  9108 , and the sensor cap  9120  may be coupled to the sharp hub  9116  at the mating member  9118 . Coupling the sensor cap  9120  to the sharp hub  9116  at the mating member  9118  may urge the first end  9122   a  of the sensor cap  9120  into sealed engagement with the seal  9208  and, more particularly, into sealed engagement with the second seal element  9210   b  on the bottom of the mount  9108 . In some embodiments, as the sensor cap  9120  is coupled to the sharp hub  9116 , a portion of the first end  9122   a  of the sensor cap  9120  may bottom out (engage) against the bottom of the mount  9108 , and the sealed engagement between the sensor hub  9116  and the first seal element  9210   a  may be able to assume any tolerance variation between features. 
       FIG.  93    is a cross-sectional side view of the sensor control device  9102 , according to one or more embodiments. As indicated above, the sensor control device  9102  may include or otherwise incorporate a sealed subassembly  9302 , which may be useful in isolating the sensor  9112  and the sharp  9114  within the inner chamber  9124  of the sensor cap  9120 . To assemble the sealed subassembly  9302 , the sensor  9112  may be located within the mount  9108  such that the tail  9224  extends through the second aperture  9202   b  at the bottom of the mount  9108 . In at least one embodiment, a locating feature  9304  may be defined on the inner surface of the mount  9108 , and the sensor  9112  may define a groove  9306  that is matable with the locating feature  9304  to properly locate the sensor  9112  within the mount  9108 . 
     Once the sensor  9112  is properly located, the collar  9212  may be installed on the mount  9108 . More specifically, the collar  9212  may be positioned such that the first seal element  9210   a  of the seal  9208  is received within the central aperture  9214  defined by the collar  9212  and the first seal element  9210   a  generates a radial seal against the collar  9212  at the central aperture  9214 . Moreover, the annular lip  9216  defined on the collar  9212  may be received within the channel  9206  defined on the mount  9108 , and the groove  9218  defined through the annular lip  9216  may be aligned to receive the portion of the sensor  9112  that traverses the channel  9206  laterally within the mount  9108 . In some embodiments, an adhesive may be injected into the channel  9206  to secure the collar  9212  to the mount  9108 . The adhesive may also facilitate a sealed interface between the two components and generate a seal around the sensor  9112  at the groove  9218 , which may isolate the tail  9224  from the interior of the electronics housing  9104 . 
     The shell  9106  may then be mated with or otherwise coupled to the mount  9108 . In some embodiments, as illustrated, the shell  9106  may mate with the mount  9108  via a tongue-and-groove engagement  9308  at the outer periphery of the electronics housing  9104 . An adhesive may be injected (applied) into the groove portion of the engagement  9308  to secure the shell  9106  to the mount  9108 , and also to create a sealed engagement interface. Mating the shell  9106  to the mount  9108  may also cause the annular ridge  9222  defined on the inner surface of the shell  9106  to be received within the collar channel  9220  defined on the upper surface of the collar  9212 . In some embodiments, an adhesive may be injected into the collar channel  9220  to secure the shell  9106  to the collar  9212 , and also to facilitate a sealed interface between the two components at that location. When the shell  9106  mates with the mount  9108 , the first seal element  9210   a  may extend at least partially through (into) the first aperture  9202   a  defined in the shell  9106 . 
     The sharp  9114  may then be coupled to the sensor control device  9102  by extending the sharp tip  9226  through the aligned first and second apertures  9202   a,b  defined in the shell  9106  and the mount  9108 , respectively. The sharp  9114  may be advanced until the sharp hub  9116  engages the seal  9208  and, more particularly, engages the first seal element  9210   a . The mating member  9118  may extend (protrude) out the second aperture  9202   b  at the bottom of the mount  9108  when the sharp hub  9116  engages the first seal element  9210   a.    
     The sensor cap  9120  may then be removably coupled to the sensor control device  9102  by threadably mating the internal threads  9128   b  of the sensor cap  9120  with the external threads  9128   a  of the mating member  9118 . The inner chamber  9124  may be sized and otherwise configured to receive the tail  9224  and the sharp tip  9226  extending from the bottom of the mount  9108 . Moreover, the inner chamber  9124  may be sealed to isolate the tail  9224  and the sharp tip  9226  from substances that might adversely interact with the chemistry of the tail  9224 . In some embodiments, a desiccant (not shown) may be present within the inner chamber  9124  to maintain proper humidity levels. 
     Tightening (rotating) the mated engagement between the sensor cap  9120  and the mating member  9118  may urge the first end  9122   a  of the sensor cap  9120  into sealed engagement with the second seal element  9210   b  in an axial direction (e.g., along the centerline of the apertures  9202   a,b ), and may further enhance the sealed interface between the sharp hub  9116  and the first seal element  9210   a  in the axial direction. Moreover, tightening the mated engagement between the sensor cap  9120  and the mating member  9118  may compress the first seal element  9210   a , which may result in an enhanced radial sealed engagement between the first seal element  9210   a  and the collar  9212  at the central aperture  9214 . Accordingly, in at least one embodiment, the first seal element  9210   a  may help facilitate axial and radial sealed engagements. 
     As mentioned above, the first and second seal elements  9210   a,b  may be overmolded onto the mount  9108  and may be physically linked or otherwise interconnected. Consequently, a single injection molding shot may flow through the second aperture  9202   b  of the mount  9108  to create both ends of the seal  9208 . This may prove advantageous in being able to generate multiple sealed interfaces with only a single injection molded shot. An additional advantage of a two-shot molded design, as opposed to using separate elastomeric components (e.g., O-rings, gaskets, etc.), is that the interface between the first and second shots is a reliable bond rather than a mechanical seal. Hence, the effective number of mechanical sealing barriers is effectively cut in half. Moreover, a two-shot component with a single elastomeric shot also has implications to minimizing the number of two-shot components needed to achieve all the necessary sterile barriers. 
     Once properly assembled, the sealed subassembly  9302  may be subjected to a radiation sterilization process to sterilize the sensor  9112  and the sharp  9114 . The sealed subassembly  9302  may be subjected to the radiation sterilization prior to or after coupling the sensor cap  9120  to the sharp hub  9116 . When sterilized after coupling the sensor cap  9120  to the sharp hub  9116 , the sensor cap  9120  may be made of a material that permits the propagation of radiation therethrough. In some embodiments, the sensor cap  9120  may be transparent or translucent, but can otherwise be opaque, without departing from the scope of the disclosure. 
       FIG.  93 A  is an exploded isometric view of a portion of another embodiment of the sensor control device  9102  of  FIGS.  91 A- 91 B and  92 A- 92 B . Embodiments included above describe the mount  9108  and the seal  9208  being manufactured via a two-shot injection molding process. In other embodiments, however, as briefly mentioned above, one or both of the seal elements  9210   a,b  of the seal  9208  may comprise an elastomeric component part independent of the mount  9208 . In the illustrated embodiment, for example, the first seal element  9210   a  may be overmolded onto the collar  9212  and the second seal element  9210   b  may be overmolded onto the sensor cap  9120 . Alternatively, the first and second seal elements  9210   a,b  may comprise a separate component part, such as a gasket or O-ring positioned on the collar  9212  and the sensor cap  9120 , respectively. Tightening (rotating) the mated engagement between the sensor cap  9120  and the mating member  9118  may urge the second seal element  9210   b  into sealed engagement with the bottom of the mount  9108  in an axial direction, and may enhance a sealed interface between the sharp hub  9116  and the first seal element  9210   a  in the axial direction. 
       FIG.  94 A  is an isometric bottom view of the mount  9108 , and  FIG.  94 B  is an isometric top view of the sensor cap  9120 , according to one or more embodiments. As shown in  FIG.  94 A , the mount  9108  may provide or otherwise define one or more indentations or pockets  9402  at or near the opening to the second aperture  9202   b . As shown in  FIG.  94 B , the sensor cap  9120  may provide or otherwise define one or more projections  9404  at or near the first end  9122   a  of the sensor cap  9120 . The projections  9404  may be received within the pockets  9402  when the sensor cap  9120  is coupled to the sharp hub  9116  ( FIGS.  92 A- 92 B and  93   ). More specifically, as described above, as the sensor cap  9120  is coupled to the mating member  9118  ( FIGS.  92 A- 92 B and  93   ) of the sensor hub  9116 , the first end  9122   a  of the sensor cap  9120  is brought into sealed engagement with the second seal element  9210   b . In this process, the projections  9404  may also be received within the pockets  9402 , which may help prevent premature unthreading of the sensor cap  9120  from the sharp hub  9116 . 
       FIGS.  95 A and  95 B  are side and cross-sectional side views, respectively, of an example sensor applicator  9502 , according to one or more embodiments. The sensor applicator  9502  may be similar in some respects to the sensor applicator  102  of  FIG.  1    and, therefore, may be designed to deliver (fire) a sensor control device, such as the sensor control device  9102 .  FIG.  95 A  depicts how the sensor applicator  9502  might be shipped to and received by a user, and  FIG.  95 B  depicts the sensor control device  9102  arranged within the interior of the sensor applicator  9502 . 
     As shown in  FIG.  95 A , the sensor applicator  9502  includes a housing  9504  and an applicator cap  9506  removably coupled to the housing  9504 . In some embodiments, the applicator cap  9506  may be threaded to the housing  9504  and include a tamper ring  9508 . Upon rotating (e.g., unscrewing) the applicator cap  9506  relative to the housing  9504 , the tamper ring  9508  may shear and thereby free the applicator cap  9506  from the sensor applicator  9502 . 
     In  FIG.  95 B , the sensor control device  9102  is positioned within the sensor applicator  9502 . Once the sensor control device  9102  is fully assembled, it may then be loaded into the sensor applicator  9502  and the applicator cap  9506  may be coupled to the sensor applicator  9502 . In some embodiments, the applicator cap  9506  and the housing  9504  may have opposing, matable sets of threads that enable the applicator cap  9506  to be screwed onto the housing  9504  in a clockwise (or counter-clockwise) direction and thereby secure the applicator cap  9506  to the sensor applicator  9502 . 
     Securing the applicator cap  9506  to the housing  9504  may also cause the second end  9122   b  of the sensor cap  9120  to be received within a cap post  9510  located within the interior of the applicator cap  9506  and extending proximally from the bottom thereof. The cap post  9510  may be configured to receive at least a portion of the sensor cap  9120  as the applicator cap  9506  is coupled to the housing  9504 . 
       FIGS.  96 A and  96 B  are perspective and top views, respectively, of the cap post  9510 , according to one or more additional embodiments. In the illustrated depiction, a portion of the sensor cap  9120  is received within the cap post  9510  and, more specifically, the desiccant cap  9130  of the sensor cap  9120  is arranged within cap post  9510 . 
     The cap post  9510  may define a receiver feature  9602  configured to receive the engagement feature  9126  of the sensor cap  9120  upon coupling (e.g., threading) the applicator cap  9506  ( FIG.  95 B ) to the sensor applicator  9502  ( FIGS.  95 A- 95 B ). Upon removing the applicator cap  9506  from the sensor applicator  9502 , however, the receiver feature  9602  may prevent the engagement feature  9126  from reversing direction and thus prevent the sensor cap  9120  from separating from the cap post  9510 . Instead, removing the applicator cap  9506  from the sensor applicator  9502  will simultaneously detach the sensor cap  9120  from the sensor control device  9102  ( FIGS.  91 A- 91 B and  92 A- 92 B ), and thereby expose the distal portions of the sensor  9112  ( FIGS.  92 A- 92 B ) and the sharp  9114  ( FIGS.  92 A- 92 B ). 
     Many design variations of the receiver feature  9602  may be employed, without departing from the scope of the disclosure. In the illustrated embodiment, the receiver feature  9602  includes one or more compliant members  9604  (two shown) that are expandable or flexible to receive the engagement feature  9126 . The engagement feature  9126  may comprise, for example, an enlarged head and the compliant member(s)  9604  may comprise a collet-type device that includes a plurality of compliant fingers configured to flex radially outward to receive the enlarged head. 
     The compliant member(s)  9604  may further provide or otherwise define corresponding ramped surfaces  9606  configured to interact with one or more opposing camming surfaces  9608  provided on the outer wall of the engagement feature  9126 . The configuration and alignment of the ramped surface(s)  9606  and the opposing camming surface(s)  9608  is such that the applicator cap  9506  is able to rotate relative to the sensor cap  9120  in a first direction A (e.g., clockwise), but the cap post  9510  binds against the sensor cap  9120  when the applicator cap  9506  is rotated in a second direction B (e.g., counter clockwise). More particularly, as the applicator cap  9506  (and thus the cap post  9510 ) rotates in the first direction A, the camming surfaces  9608  engage the ramped surfaces  9606 , which urge the compliant members  9604  to flex or otherwise deflect radially outward and results in a ratcheting effect. Rotating the applicator cap  9506  (and thus the cap post  9510 ) in the second direction B, however, will drive angled surfaces  9610  of the camming surfaces  9608  into opposing angled surfaces  9612  of the ramped surfaces  9606 , which results in the sensor cap  9120  binding against the compliant member(s)  9604 . 
       FIG.  97    is a cross-sectional side view of the sensor control device  9102  positioned within the applicator cap  9506 , according to one or more embodiments. As illustrated, the opening to the receiver feature  9602  exhibits a first diameter D 3 , while the engagement feature  9126  of the sensor cap  9120  exhibits a second diameter D 4  that is larger than the first diameter D 3  and greater than the outer diameter of the remaining portions of the sensor cap  9120 . As the sensor cap  9120  is extended into the cap post  9510 , the compliant member(s)  9604  of the receiver feature  9602  may flex (expand) radially outward to receive the engagement feature  9126 . In some embodiments, as illustrated, the engagement feature  9126  may provide or otherwise define an angled outer surface that helps bias the compliant member(s)  9604  radially outward. Once the engagement feature  9126  bypasses the receiver feature  9602 , the compliant member(s)  9604  are able to flex back to (or towards) their natural state and thus lock the sensor cap  9120  within the cap post  9510 . 
     As the applicator cap  9506  is threaded to (screwed onto) the housing  9504  ( FIGS.  95 A- 95 B ) in the first direction A, the cap post  9510  correspondingly rotates in the same direction and the sensor cap  9120  is progressively introduced into the cap post  9510 . As the cap post  9510  rotates, the ramped surfaces  9606  of the compliant members  9604  ratchet against the opposing camming surfaces  9608  of the sensor cap  9120 . This continues until the applicator cap  9506  is fully threaded onto (screwed onto) the housing  9504 . In some embodiments, the ratcheting action may occur over two full revolutions of the applicator cap  9506  before the applicator cap  9506  reaches its final position. 
     To remove the applicator cap  9506 , the applicator cap  9506  is rotated in the second direction B, which correspondingly rotates the cap post  9510  in the same direction and causes the camming surfaces  9608  (i.e., the angled surfaces  9610  of  FIGS.  96 A- 96 B ) to bind against the ramped surfaces  9606  (i.e., the angled surfaces  9612  of  FIGS.  96 A- 96 B ). Consequently, continued rotation of the applicator cap  9506  in the second direction B causes the sensor cap  9120  to correspondingly rotate in the same direction and thereby unthread from the mating member  9118  to allow the sensor cap  9120  to detach from the sensor control device  9102 . Detaching the sensor cap  9120  from the sensor control device  9102  exposes the distal portions of the sensor  9112  and the sharp  9114 , and thus places the sensor control device  9102  in position for firing (use). 
       FIG.  98    is a cross-sectional view of a sensor control device  9800  showing example interaction between the sensor and the sharp. After assembly of the sharp, the sensor should sit in a channel defined by the sharp. The sensor control device in  FIG.  9    does not show the sensor deflected inwards and otherwise aligned fully with the sharp, but such may be the case upon full assembly as slight bias forces may be assumed by the sensor at the locations indicated by the two arrows A. Biasing the sensor against the sharp may be advantageous so that any relative motion between the sensor and the sharp during subcutaneous insertion does not expose the sensor tip (i.e., the tail) outside the sharp channel, which could potentially cause an insertion failure. 
     Embodiments disclosed herein include: 
     CC. A sensor control device that includes an electronics housing including a shell that defines a first aperture and a mount that defines a second aperture alignable with the first aperture when the shell is coupled to the mount, a seal overmolded onto the mount at the second aperture and comprising a first seal element overmolded onto a pedestal protruding from an inner surface of the mount, and a second seal element interconnected with the first seal element and overmolded onto a bottom of the mount, a sensor arranged within the electronics housing and having a tail extending through the second aperture and past the bottom of the mount, and a sharp that extends through the first and second apertures and past the bottom of the electronics housing. 
     DD. An assembly that includes a sensor applicator, a sensor control device positioned within the sensor applicator and including an electronics housing including a shell that defines a first aperture and a mount that defines a second aperture alignable with the first aperture when the shell is mated to the mount, a seal overmolded onto the mount at the second aperture and comprising a first seal element overmolded onto a pedestal protruding from an inner surface of the mount, and a second seal element interconnected with the first seal element and overmolded onto a bottom of the mount, a sensor arranged within the electronics housing and having a tail extending through the second aperture and past the bottom of the mount, and a sharp that extends through the first and second apertures and past the bottom of the electronics housing. The assembly further including a sensor cap removably coupled to the sensor control device at the bottom of the mount and defining a sealed inner chamber that receives the tail and the sharp, and an applicator cap coupled to the sensor applicator. 
     Each of embodiments CC and DD may have one or more of the following additional elements in any combination: Element 1: wherein the mount comprises a first injection molded part molded in a first shot, and the seal comprises a second injection molded part overmolded onto the first injection molded part in a second shot. Element 2: further comprising a sharp hub that carries the sharp and sealingly engages the first seal element, and a sensor cap removably coupled to the sharp hub at the bottom of the mount and sealingly engaging the second seal element, wherein the sensor cap defines an inner chamber that receives the tail and the sharp. Element 3: wherein the sharp hub provides a mating member that extends past the bottom of the mount and the sensor cap is removably coupled to the mating member. Element 4: further comprising one or more pockets defined on the bottom of the mount at the second aperture, and one or more projections defined on an end of the sensor cap and receivable within the one or more pockets when the sensor cap is coupled to the sharp hub. Element 5: further comprising a collar positioned within the electronics housing and defining a central aperture that receives and sealingly engages the first seal element in a radial direction. Element 6: further comprising a channel defined on the inner surface of the mount and circumscribing the pedestal, an annular lip defined on an underside of the collar and matable with the channel, and an adhesive provided in the channel to secure and seal the collar to the mount at the channel. Element 7: further comprising a groove defined through the annular lip to accommodate a portion of the sensor extending laterally within the mount, wherein the adhesive seals about the sensor at the groove. Element 8: further comprising a collar channel defined on an upper surface of the collar, an annular ridge defined on an inner surface of the shell and matable with the collar channel, and an adhesive provided in the collar channel to secure and seal the shell to the collar. Element 9: wherein one or both of the first and second seal elements define at least a portion of the second aperture. Element 10: wherein the first seal element extends at least partially through the first aperture when the shell is coupled to the mount. 
     Element 11: wherein the sensor control device further includes a sharp hub that carries the sharp and sealingly engages the first seal element, and wherein the sensor cap is removably coupled to the sharp hub at the bottom of the mount and sealingly engages the second seal element. Element 12: wherein the sensor control device further includes one or more pockets defined on the bottom of the mount at the second aperture, and one or more projections defined on an end of the sensor cap and receivable within the one or more pockets when the sensor cap is coupled to the sharp hub. Element 13: wherein the sensor control device further includes a collar positioned within the electronics housing and defining a central aperture that receives and sealingly engages the first seal element in a radial direction. Element 14: wherein the sensor control device further includes a channel defined on the inner surface of the mount and circumscribing the pedestal, an annular lip defined on an underside of the collar and matable with the channel, and an adhesive provided in the channel to secure and seal the collar to the mount at the channel. Element 15: wherein the sensor control device further includes a groove defined through the annular lip to accommodate a portion of the sensor extending laterally within the mount, and wherein the adhesive seals about the sensor at the groove. Element 16: wherein the sensor control device further includes a collar channel defined on an upper surface of the collar, an annular ridge defined on an inner surface of the shell and matable with the collar channel, and an adhesive provided in the collar channel to secure and seal the shell to the collar. Element 17: wherein one or both of the first and second seal elements define at least a portion of the second aperture. Element 18: wherein the first seal element extends at least partially through the first aperture. 
     By way of non-limiting example, exemplary combinations applicable to CC and DD include: Element 2 with Element 3; Element 2 with Element 4; Element 5 with Element 6; Element 6 with Element 7; Element 5 with Element 8; Element 11 with Element 12; Element 13 with Element 14; Element 14 with Element 15; and Element 13 with Element 16. 
     Axial-Radial Thermal Cycle Resistant Cap Seal 
       FIG.  99    is a cross-sectional side view of an example analyte monitoring system enclosure  9900  used to house at least a portion of the sensor control device  104  of  FIG.  1   , according to one or more embodiments. As illustrated, the analyte monitoring system enclosure  9900  includes the sensor applicator  102  and the applicator cap  210  matable with the sensor applicator  102 . The applicator cap  210  provides a barrier that protects the internal contents of the sensor applicator  102 . In some embodiments, the applicator cap  210  may be secured to the housing  208  by a threaded engagement and, upon rotating (e.g., unscrewing) the applicator cap  210  relative to the housing  208 , the applicator cap  210  can be freed from the sensor applicator  102 . In other embodiments, however, the applicator cap  210  may be secured to the housing  208  via an interference or shrink fit engagement. 
     As described herein below, the coupled engagement between the sensor applicator  102  and the applicator cap  210  may prove vital in properly sterilizing the components positioned within the sensor applicator  102  and maintaining a sterile environment as sealed with the applicator cap  210 . The embodiments described herein below may be applicable to analyte monitoring systems that incorporate a two-piece or a one-piece architecture. More particularly, in embodiments employing a two-piece architecture, the electronics housing (not shown) that retains the electrical components for the sensor control device  104  ( FIG.  1   ) may be positioned within the sensor applicator  102  and the applicator cap  210  maintains the sterile environment. In contrast, in embodiments employing a one-piece architecture, the sensor applicator  102  may contain the fully assembled sensor control device  104  (not shown), and the applicator cap  210  maintains the sterile environment for the fully assembled sensor control device. 
     The components arranged within the sensor applicator  102  and sealed with the applicator cap  210  may be subjected to gaseous chemical sterilization  9902  configured to sterilize exposed portions of such components. To accomplish this, a chemical may be injected into a sterilization chamber  9904  cooperatively defined by the housing  208  and the interconnected cap  210 . In some applications, the chemical may be injected into the sterilization chamber  9904  via one or more vents  9906  (two shown) defined in the applicator cap  210  at its proximal end  9908 . Example chemicals that may be used for the gaseous chemical sterilization  9902  include, but are not limited to, ethylene oxide, vaporized hydrogen peroxide, and nitrogen oxide (e.g., nitrous oxide, nitrogen dioxide, etc.). 
     Once a desired sterility assurance level has been achieved within the sterilization chamber  9904 , the gaseous solution may be evacuated via the vents  9906  and the sterilization chamber  9904  is aerated. Aeration may be achieved by a series of vacuums and subsequently circulating nitrogen gas or filtered air through the sterilization chamber  9904 . Once the sterilization chamber  9904  is properly aerated, the vents  9906  may be occluded with a seal  9910  (shown in dashed lines). 
     In some embodiments, the seal  9910  may comprise two or more layers of different materials. The first layer may be made of a synthetic material (e.g., a flash-spun high-density polyethylene fiber), such as Tyvek® available from DuPont®. Tyvek® is highly durable and puncture resistant and allows the permeation of vapors. The Tyvek® layer can be applied before the gaseous chemical sterilization process, and following the gaseous chemical sterilization process, a foil or other vapor and moisture resistant material layer may be sealed (e.g., heat sealed) over the Tyvek® layer to prevent the ingress of contaminants and moisture into the sterilization chamber  9904 . In other embodiments, the seal  9910  may comprise only a single protective layer applied to the applicator cap  210 . In such embodiments, the single layer is gas permeable for the sterilization process, but is also capable of protection against moisture and other harmful elements once the sterilization process is complete. 
     With the seal  9910  in place, the applicator cap  210  provides a barrier against outside contamination, and thereby maintains a sterile environment for the components arranged within the sensor applicator  102  until the user removes (unthreads) the applicator cap  210  from the housing  208 . 
       FIG.  100 A  is an enlarged cross-sectional side view of the interface between the sensor applicator  102  and the applicator cap  210 , as indicated by the dashed box of  FIG.  99   . As illustrated the housing  208  provides a first axial extension  10002   a  and the applicator cap  210  provides a second axial extension  10002   b  matable with the first axial extension  10002   a . In the illustrated embodiment, the diameter of the second axial extension  10002   b  of the applicator cap  210  is sized to receive the diameter of the first axial extension  10002   a  of the housing  208 . In other embodiments, however, the reverse may be employed, where the diameter of the first axial extension  10002   a  may be sized to receive the diameter of the second axial extension  10002   b , without departing from the scope of the disclosure. 
     In either scenario, a radial seal  10004  may be defined or otherwise provided at the interface between the first and second axial extensions  10002   a,b  and the radial seal  10004  may help prevent migration of fluids or contaminants across the interface in either axial direction. In the illustrated embodiment, the radial seal  10004  comprises a radial protrusion formed on the inner radial surface of the second axial extension  10002   b . In other embodiments, however, the radial seal  10004  may alternatively be formed on the outer radial surface of the first axial extension  10002   a , without departing from the scope of the disclosure. In embodiments where the second axial extension  10002   b  is received within the first axial extension  10002   a , the radial seal  10004  may be formed on the inner radial surface of the first axial extension  10002   a  or alternatively on the outer radial surface of the second axial extension  10002   b.    
     Gaseous chemical sterilization  9902  ( FIG.  99   ) is commonly undertaken at elevated temperatures reaching 60° C. (140° F.) or more. At such elevated temperatures, the housing  208  and the applicator cap  210  may be subjected to thermal expansion that may affect the integrity of the radial seal  10004 . The housing  208  and the applicator cap  210  may be made of dissimilar materials that have dissimilar coefficients of thermal expansion. In some embodiments, for example, the housing  208  may be made of polycarbonate and the applicator cap  210  may be made of polypropylene. Polypropylene exhibits a coefficient of thermal expansion of about 100-180 10 −6 K −1  and polycarbonate exhibits a coefficient of thermal expansion of about 66-70 10 −6 K −1 . Since polypropylene has a thermal coefficient that is higher than polycarbonate, the applicator cap  210  will tend to expand at a greater rate than the polycarbonate housing  208  during gaseous chemical sterilization  9902 . Moreover, the increased expansion of the applicator cap  210  can affect the seal integrity (capability) of the radial seal  10004 . 
       FIG.  100 B  is an enlarged cross-sectional side view of the interface between the sensor applicator  102  and the applicator cap  210 , as indicated by the dashed box of  FIG.  99    during and/or after gaseous chemical sterilization. Since the applicator cap  210  exhibits a thermal coefficient greater than the thermal coefficient of the housing  208 , the applicator cap  210  expands at a greater rate than the housing  208  upon being subjected to the elevated temperatures required for gaseous chemical sterilization  9902  ( FIG.  99   ). Consequently, a gap  10006  may be created between the opposing radial surfaces of the first and second axial extensions  10002   a,b  as the radial seal  10004  separates from opposed radial engagement. As shown by the arrows, the gap  10006  may provide a flow path for the outflow of toxic gases used for gaseous chemical sterilization  9902 . 
     Following gaseous chemical sterilization  9902 , and as the temperature is lowered to ambient, the applicator cap  210  may radially contract and the gap  10006  may close, thereby sealing the interface at the radial seal  10004  once again. Such embodiments may prove advantageous in simplifying the design of the applicator cap  210 . More specifically, and according to one or more embodiments of the present disclosure, the gaseous chemical sterilization  9902  process may be carried out entirely through the gap  10006  formed between the opposing radial surfaces of the first and second axial extensions  10002   a,b . In such embodiments, the temperature of the housing  208  and the applicator cap  210  may be elevated until the gap  10006  is created. Once the gap  10006  is created, the gaseous chemicals (e.g., ethylene oxide) used during the gaseous chemical sterilization  9902  may be injected into the sterilization chamber  9904  through the gap  10006  and otherwise by bypassing the radial seal  10004 . The sterilization chamber  9904  may be subsequently aerated by drawing out the gaseous chemicals through the gap  10006  and circulating another fluid, such as nitrogen, into and out of the sterilization chamber  9904  via the gap  10006 . 
     In such embodiments, the vents  9906  ( FIG.  99   ) defined in the applicator cap  210  and the seal  9910  ( FIG.  99   ) attached to the bottom of the applicator cap  210  may be omitted and otherwise unnecessary. Accordingly, in such embodiments, the bottom of the applicator cap  210  may be solid. Moreover, in such embodiments, a desiccant may be positioned within the applicator cap  210  or the sterilization chamber  9904  to aid maintenance of a low humidity environment for biological components sensitive to moisture. 
     In other embodiments, however, the applicator cap  210  may undergo stress relaxation at the enlarged diameter during gaseous chemical sterilization  9902 . This may occur in embodiments where the material of the applicator cap  210  exhibits a thermal coefficient greater than the material of the housing  208  and the gaseous chemical sterilization  9902  spans a long period of time (e.g., one hour, five hours, ten hours, fifteen hours, or more). As the temperature is lowered to ambient, the applicator cap  210  may remain substantially at the enlarged diameter and the gap  10006  may correspondingly remain, which jeopardizes the integrity of the radial seal  10004 . 
     Stress relaxation of the applicator cap  210  may also occur in embodiments where the housing  208  is made of a material that has a higher thermal coefficient than the applicator cap  210 . In such embodiments, the housing  208  will expand at a greater rate than the applicator cap  210  and thereby radially expand against the applicator cap  210 . The gap  10006  will not be generated as the housing  208  continuously biases against the applicator cap  210  during thermal expansion. The material of the applicator cap  210 , however, will undergo stress relaxation at an enlarged diameter, and upon cooling the system to ambient, the gap  10006  may be generated as the housing  208  radially contracts but the applicator cap  210  remains near the enlarged diameter. The resulting gap  10006  compromises the sealed interface at the radial seal  10004 , and thereby prevents the applicator cap  210  from providing a barrier. 
       FIG.  101    is an enlarged cross-sectional side view of another example analyte monitoring system enclosure  10100  used to house at least a portion of the sensor control device  104  of  FIG.  1   , according to one or more embodiments. Similar to the analyte monitoring system enclosure  9900  of  FIGS.  99  and  1007 A- 100 B , the analyte monitoring system enclosure  10100  includes the sensor applicator  102  and the applicator cap  210  matable with the sensor applicator  102 . In the illustrated embodiment, the applicator cap  210  is secured to the housing  208  by complimentary mating threads  10102 , and may include a tamper ring  10104 . Upon rotating (e.g., unscrewing) the applicator cap  210  relative to the housing  208 , the tamper ring  10104  may shear and thereby free the applicator cap  210  from the sensor applicator  102 . 
     As best seen in the enlarged view, the interface between the housing  208  and the applicator cap  210  may provide or otherwise define a radial seal  10106  and an axial-radial seal  10108 . More specifically, the housing  208  may provide a first axial extension  10110   a  and the applicator cap  210  may provide a second axial extension  10110   b  extending in the opposite direction. In the illustrated embodiment, the diameter of the first axial extension  10110   a  may be sized to receive the smaller diameter second axial extension  10110   b  of the applicator cap  210 . In other embodiments, however, the diameter of the second axial extension  10110   b  may be sized to receive a smaller diameter first axial extension  10110   a  of the housing  208 , without departing from the scope of the disclosure. 
     In either scenario, the radial seal  10106  may be defined or otherwise provided at an interface between the first and second axial extensions  10110   a,b  and configured to help prevent the migration of fluids or contaminants across the interface in either axial direction. In the illustrated embodiment, the radial seal  10106  comprises a radial protrusion  10107  formed on the outer radial surface of the second axial extension  10110   b , but the radial protrusion  10107  may alternatively be formed on the inner radial surface of the first axial extension  10110   a , without departing from the scope of the disclosure. In embodiments where the first axial extension  10110   a  is received within the second axial extension  10110   b , the radial seal  10106  may be formed on the outer radial surface of the first axial extension  10110   a  or alternatively on the inner radial surface of the second axial extension  10110   b.    
     As its name suggests, the axial-radial seal  10108  may be configured to provide a sealed interface between the housing  208  and the applicator cap  210  in both axial and radial directions, and thereby prevent the migration of fluids or contaminants across the interface in both axial and radial directions. To accomplish this, the axial-radial seal  10108  may comprise a beveled or chamfered surface  10112  configured to mate with a fillet  10114 , where the fillet  10114  comprises angularly offset surfaces angled to substantially mate with the angled profile of the chamfered surface  10112  in both axial and radial directions. In the illustrated embodiment, the chamfered surface  10112  is defined on the end of the second axial extension  10110   b  and the fillet  10114  is defined by the first axial extension  10110   a . In other embodiments, however, the chamfered surface  10112  may alternatively be defined on the end of the first axial extension  10110   a  and the fillet  10114  may be defined by the second axial extension  10110   b , without departing from the scope of the disclosure. 
     The radial seal  10106  and the axial-radial seal  10108  may be configured to cooperatively help maintain fluid tight interfaces between the housing  208  and the applicator cap  210 . During gaseous chemical sterilization  9902  ( FIG.  99   ), however, and since the housing  208  and the applicator cap  210  may be made of dissimilar materials having dissimilar coefficients of thermal expansion, the elevated temperatures may result in loss of a fluid tight seal at the radial seal  10106 . Nonetheless, the axial-radial seal  10108  may be designed and otherwise configured to maintain a fluid tight interface between the housing  208  and the applicator cap  210  while withstanding the elevated temperatures of gaseous chemical sterilization  9902 . Regardless of the materials of either of the housing  208  or the applicator cap  210 , and regardless of the respective coefficients of thermal expansion, the axial-radial seal  10108  may prove advantageous in maintaining a fluid tight interface. In some embodiments, the applicator cap  210  may provide a sterile barrier. 
       FIGS.  102 A- 102 C  depict finite element analysis (FEA) results corresponding to the interface between the housing  208  and the applicator cap  210  during example gaseous chemical sterilization, according to one or more embodiments.  FIG.  102 A  depicts FEA analysis results as the applicator cap  210  is secured to the housing  208 , such as by screwing the applicator cap  210  onto the housing  208  via the threads  10102  ( FIG.  101   ). As illustrated, a radial preload may be generated at the radial seal  10106  as the radial protrusion  10107  provided on the second axial extension  10110   b  is urged into radial contact with the inner radial surface of the first axial extension  10110   a . Moreover, a combination axial and radial preload may be generated at the axial-radial seal  10108  as the chamfered surface  10112  is urged into both axial and radial engagement with the fillet  10114 . 
       FIG.  102 B  depicts FEA analysis results during an increase in temperature resulting from gaseous chemical sterilization. The temperature increase results in differential expansion between the materials of the housing  208  and cap  210 . Depending on the materials chosen, the applicator cap  210  may expand radially more or less than the housing  208 . During this temperature increase and the radial expansion of the housing  208  and the applicator cap  210 , the axial-radial seal  10108  remains intact as the chamfered surface  10112  is wedged into both axial and radial engagement with the fillet  10114 . Hence, the expansion of the fillet  10114  may dictate the final position of the axial-radial seal  10108  at elevated temperature. Depending upon whether the housing  208  material has a higher coefficient of thermal expansion than the applicator cap  210  material, or vice-versa, this result may or may not apply to the radial seal  10106 . 
     The elevated temperatures during gaseous chemical sterilization are typically maintained for long periods of time. During this time, stress relaxation may occur in all the stressed zones of the applicator cap  210  and insignificant residual stress is expected at the end of the temperature cycle. This implies that most of the preload (and hence sealing) is lost at elevated temperature. 
       FIG.  102 C  depicts FEA analysis results after decreasing the temperature following gaseous chemical sterilization. In embodiments where the applicator cap  210  is made of a material having a higher coefficient of thermal expansion than the housing  208 , the radial seal  10106  is likely lost upon decreasing the temperature to ambient due to stress relaxation at the elevated temperature. As a result, separation of the first and second axial extensions  10110   a,b  occurs and a gap  2816  is formed between the two surfaces after cooling. In contrast, in embodiments where the housing  208  is made of a material having a higher coefficient of thermal expansion than the applicator cap  210 , the radial seal  10106  may be re-activated following cooling. In either scenario, however, the axial-radial seal  10108  may remain intact throughout the temperature cycle as the chamfered surface  10112  is continuously wedged into both axial and radial engagement with the fillet  10114 . Accordingly, the axial-radial seal  10108  may prove advantageous in maintaining sealed engagement between the housing  208  and the applicator cap  210  regardless of the materials used. 
     Embodiments disclosed herein include: 
     EE. An analyte monitoring system enclosure including a sensor applicator including a housing that provides a first axial extension, a cap matable with the housing and providing a second axial extension, and an axial-radial seal that seals an interface between the housing and the cap in both axial and radial directions, wherein the axial-radial seal includes a fillet defined by one of the first and second axial extensions, and a chamfered surface matable with the fillet and defined on an end of the other of the first and second axial extensions. 
     FF. A method of sterilizing contents within an analyte monitoring system enclosure including injecting a chemical gas into the analyte monitoring system enclosure, the analyte monitoring system enclosure comprising a sensor applicator including a housing that provides a first axial extension, and a cap matable with the housing and providing a second axial extension. The method further including sealing an interface between the housing and the cap in both axial and radial directions with an axial-radial seal, wherein the axial-radial seal includes a fillet defined by one of the first and second axial extensions, and a chamfered surface matable with the fillet and defined on an end of the other of the first and second axial extensions, increasing and decreasing a temperature of the analyte monitoring system enclosure, and maintaining the axial-radial seal as the temperature is increased and decreased. 
     GG. A method of sterilizing contents within an analyte monitoring system enclosure including providing the analyte monitoring system enclosure, the analyte monitoring system enclosure comprising a sensor applicator including a housing that provides a first axial extension, and a cap matable with the housing and providing a second axial extension. The method further including increasing a temperature of the analyte monitoring system enclosure until a gap forms between the first and second axial extensions, injecting a chemical gas into the analyte monitoring system enclosure through the gap, evacuating the chemical gas from the analyte monitoring system enclosure through the gap, and decreasing the temperature of the analyte monitoring system and sealing an interface between the first and second axial extensions with a radial seal. 
     Each of embodiments EE, FF, and GG may have one or more of the following additional elements in any combination: Element 1: wherein the housing and the cap are made of dissimilar materials having dissimilar coefficients of thermal expansion. Element 2: wherein the fillet comprises angularly offset surfaces angled to mate with an angled profile of the chamfered surface in both the axial and radial directions. Element 3: further comprising a radial seal provided between the first and second axial extensions. Element 4: wherein the radial seal comprises a radial protrusion formed on an inner or outer surface of one of the first and second axial extensions. Element 5: wherein the first axial extension is received within the second axial extension and the radial protrusion is formed on the outer surface of the first axial extension or the inner surface of the second axial extension. Element 6: wherein the second axial extension is received within the first axial extension and the radial protrusion is formed on the inner surface of the first axial extension or the outer surface of the second axial extension. Element 7: wherein the cap is secured to the housing via a threaded engagement. 
     Element 8: wherein maintaining the axial-radial seal comprises wedging the chamfered surface into one or both of axial and radial engagement with the fillet as the temperature is increased and decreased. Element 9: wherein the housing and the cap are made of dissimilar materials having dissimilar coefficients of thermal expansion. Element 10: further comprising radially sealing an interface between the housing and the cap with a radial seal. Element 11: wherein the radial seal comprises a radial protrusion formed on an inner radial surface or an outer radial surface of one of the first and second axial extensions, and wherein radially sealing the interface comprises urging the radial protrusion into engagement with an opposing surface of the other of the first and second axial extensions. Element 12: wherein the cap is secured to the housing via a threaded engagement. 
     Element 13: wherein the housing and the cap are made of dissimilar materials having dissimilar coefficients of thermal expansion. Element 14: wherein the radial seal comprises a radial protrusion formed on an inner radial surface or an outer radial surface of one of the first and second axial extensions, and wherein radially sealing the interface comprises urging the radial protrusion into engagement with an opposing surface of the other of the first and second axial extensions. Element 15: wherein the bottom of the cap is solid without vents formed therein. Element 16: further maintaining a low humidity environment within the cap with a desiccant. 
     By way of non-limiting example, exemplary combinations applicable to EE, FF, and GG include: Element 3 with Element 4; Element 4 with Element 5; Element 4 with Element 6; and Element 10 with Element 11. 
     Conversion Process for Sensor Control Devices 
     Referring again briefly to  FIG.  1   , the sensor control device  104  is often included with the sensor applicator  104  in what is known as a “two-piece” architecture that requires final assembly by a user before the sensor  110  can be properly delivered to the target monitoring location. More specifically, the sensor  110  and the associated electrical components included in the sensor control device  104  are provided to the user in multiple (two) packages, and the user must open the packaging and follow instructions to manually assemble the components before delivering the sensor  110  to the target monitoring location with the sensor applicator  102 . More recently, advanced designs of sensor control devices and sensor applicators have resulted in a one-piece architecture that allows the system to be shipped to the user in a single, sealed package that does not require any final user assembly steps. Rather, the user need only open one package and subsequently deliver the sensor control device to the target monitoring location. Notwithstanding these advancements, however, sensor control devices are still frequently made of hard plastic materials that contain several component parts. 
     According to the present disclosure, sensor control devices (e.g., the sensor control device  104 ) may alternatively be manufactured through a converting process that incorporate large rolls of process material that are progressively modified to form or otherwise assemble flexible sensor control devices in step-wise fashion. The converting processes described herein may use pressure sensitive adhesives (PSAs) or tapes, thermoformed films, die-cut or layered components, and other materials that readily lend themselves to roll-to-roll or other high volume manufacturing processes. These high-volume manufacturing processes have the potential to greatly decrease the cost of manufacturing sensor control devices and increase the rate of assembly. 
       FIG.  103    is an isometric view of an example sensor control device  10302 , according to one or more embodiments of the present disclosure. The sensor control device  10302  may be the same as or similar to the sensor control device  104  of  FIG.  1    and, therefore, may be used in conjunction with the sensor applicator  102  ( FIG.  1   ), which delivers the sensor control device  10302  to a target monitoring location on a user&#39;s skin. 
     As illustrated, the sensor control device  10302  includes an electronics housing  10304  that is generally planar in shape and can exhibit a variety of cross-sectional shapes. In the illustrated embodiment, the electronics housing  10304  is rectangular with rounded corners, but could exhibit other cross-sectional shapes, such as circular, oval, ovoid (e.g., pill- or egg-shaped), a squircle, another polygonal shape (e.g., square, pentagonal, etc.), or any combination thereof, without departing from the scope of the disclosure. The electronics housing  10304  may be configured to house or otherwise contain various electronic components used to operate the sensor control device  10302 . 
     The electronics housing  10304  may include an upper cover  10306  and a lower cover  10308  that is matable with the upper cover  10306 . In some embodiments, the upper and lower covers  10306 ,  10308  may comprise a film, a foil, a foam, a laminated material (e.g., a laminated metal or foil), a coextruded material, a cast film, a comolded material, or any combination thereof. Accordingly, the upper and lower covers  10306 ,  10308  may be made of a variety of semi-rigid or flexible materials including, but not limited to, a plastic or thermoplastic, a metal, a composite material (e.g., fiberglass, etc.), or any combination thereof. Moreover, the upper and lower covers  10306 ,  10308  may be formed via a variety of manufacturing processes including, but not limited to, thermoforming, vacuum forming, injection molding, die-cutting, stamping, compression molding, transfer molding, or any combination thereof. 
     The upper cover  10306  may be secured to the lower cover  10308  via a variety of mating techniques, such as sonic welding, ultrasonic welding, laser welding, heat sealing, an adhesive substrate (e.g., a pressure sensitive adhesive or tape), or any combination thereof. In some cases, the upper cover  10306  may be secured to the lower cover  10308  such that a sealed interface is generated therebetween. The sealed interface may provide structural integrity, but may also isolate the interior of the electronics housing  10304  from outside contamination. In the illustrated embodiment, securing the upper cover  10306  to the lower cover  10308  may result in the formation of a flange  10322  extending about the periphery of the electronics housing  10304 . In other embodiments, however, the upper and lower covers  10306 ,  10308  may be secured without forming the flange  10322 . 
     In the illustrated embodiment, the sensor control device  10302  may optionally include a plug assembly  10310  that may be coupled to the electronics housing  10304 . The plug assembly  10310  may include a sensor module  10312  (partially visible) interconnectable with a sharp module  10314  (partially visible). The sensor module  10312  may be configured to carry and otherwise include a sensor  10316  (partially visible), and the sharp module  10314  may be configured to carry and otherwise include an introducer or sharp  10318  (partially visible) used to help deliver the sensor  10316  transcutaneously under a user&#39;s skin during application of the sensor control device  10302 . In the illustrated embodiment, the sharp module  10314  includes a sharp hub  10320  that carries the sharp  10318 . 
     As illustrated, corresponding portions of the sensor  10316  and the sharp  10318  extend distally from the electronics housing  10304  and, more particularly, from the bottom of the lower cover  10308 . In at least one embodiment, the exposed portion of the sensor  10316  (alternately referred to as the “tail”) may be received within a hollow or recessed portion of the sharp  10318 . The remaining portions of the sensor  10316  are positioned within the interior of the electronics housing  10304 . 
       FIGS.  104 A and  104 B  are exploded, isometric views of the sensor control device  10302  of  FIG.  103   , according to one or more embodiments. More specifically,  FIG.  104 A  is an exploded, isometric view of a sensor electronics module  10402  included in the sensor control device  10302 , and  FIG.  104 B  is an exploded, isometric view of the sensor control device  10302  with the sensor electronics module  10402 . 
     Referring first to  FIG.  104 A , the sensor electronics module  10402  may include a cap  10404 , a sensor holder  10406 , the sensor  10316 , and a printed circuit board (PCB)  10408 . The cap  10404  and the sensor holder  10406  may be made of injection molded plastic, for example, and may be configured to secure the sensor  10316  within the sensor electronics module  10402 . To accomplish this, the cap  10404  and the sensor holder  10406  may be engageable and matable. In the illustrated embodiment, for example, the cap  10404  includes or defines one or more castellations or projections  10410  sized to be received within or mate with one or more corresponding grooves or pockets  10412  defined on the sensor holder  10406 . Mating the projections  10410  with the pockets  10412  may help secure the sensor  10316  within the sensor electronics module  10402  and may also clamp down on the PCB  10408  and the other component parts of the sensor electronics module  10402 , thus resulting in a solid structural component. In other embodiments, however, the projections  10410  may alternatively be provided on the sensor holder  10406 , and the cap  10404  may instead define the pockets  10412 , without departing from the scope of the disclosure. 
     As illustrated, the sensor  10316  includes a tail  10314 , a flag  10416 , and a neck  10418  that interconnects the tail  10314  and the flag  10416 . The tail  10314  may be configured to extend at least partially through a channel  10420  defined in the sensor holder  10406  and extend distally from the sensor electronics module  10402 . The tail  10314  includes an enzyme or other chemistry or biologic and, in some embodiments, a membrane may cover the chemistry. In use, the tail  10314  is transcutaneously received beneath a user&#39;s skin, and the chemistry included thereon helps facilitate analyte monitoring in the presence of bodily fluids. The flag  10416  may comprise a generally planar surface having one or more sensor contacts  10422  (three shown) arranged thereon. The sensor contacts  10422  may be configured to align with a corresponding number of circuitry contacts (not shown) included on the PCB  10408  that provide conductive communication between the sensor  10316  and the electronic components provided on the PCB  10408 . 
     In some embodiments, the PCB  10408  may be flexible, and may be sized to be positioned within the electronics housing  10304  ( FIG.  103   ). A plurality of electronic modules (not shown) may be mounted to the PCB  10408  including, but not limited to, a data processing unit, resistors, transistors, capacitors, inductors, diodes, and switches. The data processing unit may comprise, for example, an application specific integrated circuit (ASIC) configured to implement one or more functions or routines associated with operation of the sensor control device  10302  ( FIGS.  103  and  104 B ). More specifically, the data processing unit may be configured to perform data processing functions, where such functions may include but are not limited to, filtering and encoding of data signals, each of which corresponds to a sampled analyte level of the user. The data processing unit may also include or otherwise communicate with an antenna for communicating with the reader device  106  ( FIG.  1   ). One or more batteries (not shown) may also be mounted to the PCB  10408  and used to power the sensor control device  10302 . 
     The sensor electronics module  10402  may further include one or more adhesive substrates, shown as a first adhesive substrate  10424   a , a second adhesive substrate  10424   b , and a third adhesive substrate  10424   c . In some embodiments, each adhesive substrate  10424   a - c  may comprise a pressure-adhesive tape that forms a bond when pressure is applied. The first adhesive substrate  10424   a  may interpose the cap  10404  and the PCB  10408  and may operate to secure the cap  10404  to the PCB  10408 . The second adhesive substrate  10424   b  may interpose the sensor holder  10406  and the sensor  10316  (i.e., the flag  10416 ) and may operate to secure the sensor  10316  to the sensor holder  10406 . 
     The third adhesive substrate  10424   c  may interpose the sensor  10316  (i.e., the flag  10416 ) and the flexible PCB  10408  to couple the sensor  10316  to the PCB  10408 . In some embodiments, the third adhesive substrate  10424   c  may also comprise a Z-axis anisotropic (or conductive) pressure-adhesive tape. In such embodiments, the third adhesive substrate  10424   c  may also facilitate electrical communication between the sensor contacts  10422  provided on the flag  10416  and the corresponding circuitry contacts included on the PCB  10408 . Coupling the cap  10404  and the sensor holder  10406  may help maintain sufficient pressure on the third adhesive substrate  10424   c  to ensure reliable electrical connection between the sensor  10316  and the PCB  10408 . Each of the adhesive substrates  320   a - c  may also seal against liquid and moisture, thus helping to mitigate the chances of shorting the sensor  10316  and the PCB  10408 . 
     Referring now to  FIG.  104 B , the sensor electronics module  10402  may be sized to be received between the upper and lower covers  10306 ,  10308 . In the illustrated embodiment, the upper cover  10306  provides or otherwise defines a cavity that may receive the sensor electronics module  10402 . In other embodiments, however, the lower cover  10308 , or both the upper and lower covers  10306 ,  10308 , could alternatively define the cavity, without departing from the scope of the disclosure. 
     The sensor control device  10302  may also include a filler  10426  that may be arranged between the upper and lower covers  10306 ,  10308 . In some embodiments, the filler  10426  may comprise foam made of a low-density polyethylene, polyolefin, or polyurethane. Moreover, the filler  10426  may be die cut and/or molded to mate with the sensor electronics module  10402 . As illustrated, for instance, the filler  10426  may define an aperture  328  sized to receive a portion of the sensor electronics module  10402  and, more particularly, the sensor holder  10406 . In some embodiments, the filler  10426  may operate similar to a potting material by taking up space within the electronics housing  10304  ( FIG.  103   ) that would otherwise be occupied by air. Moreover, the material of the filler  10426  may expand less than air at elevated altitudes, such as would be experienced during shipping. The filler  10426  may also help to stabilize the electrical components of the PCB  10408  ( FIG.  104 B ) and mitigate vibration. 
     The sensor control device  10302  may further include a fourth adhesive substrate  10424   d , which may also comprise a pressure-adhesive tape that forms a bond when pressure is applied. The fourth adhesive substrate  10424   b  may interpose the lower cover  10308  and the filler  10426 , and may operate to secure the filler  10426  to the lower cover  10308 . The adhesive substrates  10424   a - d  may each be die-cut, thermoformed, or stamped pieces of material. 
       FIG.  105    is a cross-sectional side view of the assembled sensor control device  10302 , according to one or more embodiments. Securing the upper and lower covers  10306 ,  10308  to one another, as described above, secures the sensor electronics module  10402  and the filler  10426  within the electronics housing  10304 . Once the upper and lower covers  10306 ,  10308  are secured, the plug assembly  10310  may be received by the sensor control device  10302  by extending the sharp  10318  through the electronics housing  10304  until the sharp hub  10320  engages a top surface  10502  of the sensor control device  10302 , such as a top surface of the cap  10404 . As the sharp  10318  extends through the electronics housing  10304 , the sensor  10316  (e.g., the tail  10314 ) may be received within a hollow or recessed portion of the sharp  10318 . 
     As described in more detail below, the sensor control device  10302  may be manufactured via a converting process, where some parts of the sensor control device  10302  are assembled or otherwise formed in a step-wise fashion from large rolls of material. As a result, the sensor control device  10302  may be entirely made at a factory, thus eliminating user assembly. Moreover, whereas current sensor control devices commonly use glues, potting, or casting and encapsulating compounds to seal and enclose (encapsulate) the sensor  10316  and the PCB  10408 , fabricating the sensor control device  10302  using the presently disclosed converting processes eliminates the need for glues or “wet chemistry,” thus making the fabrication process not dependent on curing methods or time. 
       FIG.  106    is an isometric view of another example sensor control device  10602 , according to one or more embodiments of the present disclosure. The sensor control device  10602  may be the same as or similar to the sensor control device  104  of  FIG.  1    and, therefore, may be used in conjunction with the sensor applicator  102  ( FIG.  1   ), which delivers the sensor control device  10602  to a target monitoring location on a user&#39;s skin. Moreover, the sensor control device  10602  may be similar in some respects to the sensor control device  10302  of  FIGS.  103 ,  104 A- 104 B and  105    and therefore may be best understood with reference thereto, where like numerals will represent like components not described again in detail. 
     Similar to the sensor control device  10302  of  FIGS.  103 ,  104 A- 104 B and  105   , the sensor control device  10602  includes the electronics housing  10304  made of the upper and lower covers  10306 ,  10308 . The sensor control device  10602  may further include the plug assembly  10310 , the sensor module  10312  with the sensor  10316 , and the sharp module  10314  with the sharp  10318 . Corresponding portions of the sensor  10316  and the sharp  10318  extend distally from the electronics housing  10304  and, more particularly, from the bottom of the lower cover  10308 . Unlike the sensor control device  10302 , however, one or both of the upper and lower covers  10306 ,  10308  may be made of a rigid material such as, but not limited to, a plastic, a metal, a composite material, a ceramic, or any combination thereof. Alternatively, one or both of the upper and lower covers  10306 ,  10308  can be made of a semi rigid or flexible materials, such as an elastomer. 
       FIGS.  107 A and  107 B  are exploded, isometric views of the sensor control device  10602  of  FIG.  106   , according to one or more embodiments. More specifically,  FIG.  107 A  is an exploded, isometric view of a sensor electronics module  10702  included in the sensor control device  10602 , and  FIG.  107 B  is an exploded, isometric view of the sensor control device  10602  with the sensor electronics module  10702 . 
     Referring first to  FIG.  107 A , the sensor electronics module  10702  includes a sensor holder  10704 , the sensor  10316 , and a printed circuit board (PCB)  10706 , which may be similar in some respects to the PCB  10408  of  FIG.  104 A . The sensor holder  10704  may be made of injection molded plastic, for example, and may be configured to secure the sensor  10316  to the sensor electronics module  10702 . To accomplish this, the sensor holder  10704  may be engageable and matable with the PCB  10706 . In the illustrated embodiment, for example, the sensor holder  10704  includes or defines one or more projections  107608  (three shown) sized to be received within or mate with one or more corresponding holes  10710  (three shown) defined on the PCB  10706 . 
     Mating the projections  107608  with the holes  10710  may secure the sensor  10316  to the sensor electronics module  10702 , thus resulting in a solid structural component. In other embodiments, however, the projections  107608  may alternatively be provided on the PCB  10706 , and the sensor holder  10704  may instead define the holes  10710 , without departing from the scope of the disclosure. 
     The tail  10314  of the sensor  10316  may be configured to extend through a channel  10712  defined in the sensor holder  10704  and extend distally from the sensor electronics module  10702 . The sensor contacts  10422  of the flag  10416  may be configured to align with a corresponding number of circuitry contacts (not shown) included on the PCB  10706  that provide conductive communication between the sensor  10316  and corresponding electronic components provided on the PCB  10706 . 
     The sensor electronics module  10702  may further include one or more adhesive substrates, shown as a first adhesive substrate  10714   a  and a second adhesive substrate  10714   b . Similar to the adhesive substrates  10424   a - d  of  FIGS.  104 A- 104 B , each adhesive substrate  10714   a,b  may comprise a pressure-adhesive tape that forms a bond when pressure is applied, and may each be die-cut, thermoformed, or stamped pieces of material. The first adhesive substrate  10714   a  may interpose the sensor holder  10704  and the sensor  10316  (i.e., the flag  10416 ) and may operate to secure the sensor  10316  to the sensor holder  10704 . In some embodiments, the sensor holder  10704  may define a depression  10716  sized to receive one or both of the first adhesive substrate  10714   a  and the flag  10416 . 
     The second adhesive substrate  10714   b  may be configured to help attach the sensor  10316  and the sensor holder  10704  to the PCB  10706 . Moreover, the second adhesive substrate  10714   b  may comprise a Z-axis anisotropic (or conductive) pressure-adhesive tape and may therefore also facilitate electrical communication between the sensor contacts  10422  provided on the flag  10416  with the corresponding circuitry contacts included on the PCB  10706 . Coupling the sensor holder  10704  to the PCB  10706  may help maintain sufficient pressure on the second adhesive substrate  10714   b  to ensure reliable electrical contact between the sensor  10316  and the PCB  10706 . The adhesive substrates  10714   a,b  may also seal against liquid and moisture, thus helping to mitigate the chances of shorting the sensor  10316  and the PCB  10706 . 
     Referring now to  FIG.  107 B , the sensor electronics module  10702  may be sized to be received between the upper and lower covers  10306 ,  10308 . In the illustrated embodiment, the upper cover  10306  provides or otherwise defines a cavity that can receive the sensor electronics module  10702 . In other embodiments, however, the lower cover  10308 , or a combination of the upper and lower covers  10306 ,  10308 , could alternatively define the cavity, without departing from the scope of the disclosure. The sensor control device  10602  may also include the filler  10426  arranged between the upper and lower covers  10306 ,  10308  and defining the aperture  10428  sized to receive a portion of the sensor electronics module  10702  and, more particularly, the sensor holder  10704 . 
       FIG.  108    is a cross-sectional side view of the assembled sensor control device  10602 , according to one or more embodiments. Securing the upper and lower covers  10306 ,  10308  to one another, as described herein, secures the sensor electronics module  10702  and the filler  10426  within the electronics housing  10304 . Once the upper and lower covers  10306 ,  10308  are secured and otherwise sealed, the plug assembly  10310  may be received by the sensor control device  10602  by extending the sharp  10318  through the electronics housing  10304  until the sharp hub  10320  engages a top surface  10802  of the sensor control device  10602 , such as a top surface of the upper cover  10306 . As the sharp  10318  extends through the electronics housing  10304 , the sensor  10316  (e.g., the tail  10314 ) may be received within a hollow or recessed portion of the sharp  10318 . 
       FIG.  109    is an isometric view of an example converting process  10900  for manufacturing a sensor control device  10902  in accordance with the principles of the present disclosure. More specifically, the converting process  10900  is depicted showing progressive, step-wise building of a web-based assembly that results in the fabrication of the sensor control device  10902 . The sensor control device  10902  may be the same as or similar to any of the sensor control devices  104 ,  10302 ,  10602  described herein with reference to  FIGS.  1 ,  103 , and  106   , respectively. Accordingly, any of the sensor control devices  104 ,  10302 ,  10602  may be fabricated using the presently described converting process  10900 . 
     Whereas current sensor control devices are commonly made of hard plastics and require use assembly, the sensor control device  10902  made by the converting process  10900  may be made of flexible materials that do not require user assembly. Alternatively, rigid materials may instead be incorporated, without departing from the scope of the disclosure. The converting process  10900  may incorporate the use of one or more continuous rolls of process materials, such as a base substrate  10904  that may eventually form the lower cover  10308  ( FIGS.  103  and  106   ) of the electronics housing  10304  ( FIGS.  103  and  106   ). The base substrate  10904  may be continuously unrolled (unwound) from an adjacent roll (not shown) of material. This web-based process may include or exclude the incorporate of injection molded parts, such as for the upper or lower covers  10306 ,  10308 . Consequently, fabrication of sensor control devices (e.g., the sensor control device  10902 ) using the converting process  10900  may proceed in a continuous process that progressively modifies and/or arranges the materials and component parts to form the sensor control devices  10902 . 
       FIGS.  110 A- 110 E  are referenced in  FIG.  109    and depict progressive fabrication of the sensor control device  10902 , according to one or more embodiments.  FIGS.  110 A- 110 E  will be described below to detail the various steps of the example converting process  10900 . 
     Referring first to  FIG.  110 A , in a first step of the process  10900 , a hole  11002  may be punched or otherwise formed in the base substrate  10904 , which may comprise a sheet of material that may eventually form the base or lower cover  10308  ( FIGS.  103  and  106   ) of the sensor control device  10902  ( FIG.  109   ). The base substrate  10904  may comprise a belt or thin film made of a variety of different materials including, but not limited to, a plastic, a metal, a composite material, or any combination thereof. In at least one embodiment, the base substrate  10904  may comprise a laminated aluminum foil having a polyester film on one side (e.g., the bottom side), and a polyolefin heat seal layer on the opposing side (e.g., the top side). 
     In a second step of the process  10900 , a sensor holder  11004  may be coupled to the base substrate  10904 . The sensor holder  11004  may be the same as or similar to either of the sensor holders  10406 ,  10704  of  FIGS.  104 A and  107 A , respectively. Accordingly, the sensor holder  11004  may define a channel  11006  sized to receive the tail  10314  ( FIGS.  104 A and  107 A ) of the sensor  10316  ( FIGS.  104 A and  107 A ). In some embodiments, the sensor holder  11004  may be ultrasonically welded or heat-sealed to the base substrate  10904 , thus resulting in a sealed and watertight engagement. In at least one embodiment, however, the base substrate  10904  may comprise or otherwise include an adhesive substrate on the top side to secure and seal the sensor holder in place. 
     In a third step of the process  10900 , a first adhesive substrate  11008   a  may be attached to the top of the sensor holder  11004 . The first adhesive substrate  11008   a  may be similar to any of the adhesive substrates  10424   a - d  ( FIGS.  104 A- 104 B ),  10714   a,b  ( FIGS.  107 A- 107 B ) described herein, and may thus comprise a pressure-adhesive tape that forms a bond when pressure is applied. In at least one embodiment, the first adhesive substrate  11008   a  may comprise double-sided polyolefin foam tape and may be pressure sensitive on both sides. 
     In a fourth step of the process  10900 , the sensor  10316  may be secured to the sensor holder  11004  using the first adhesive substrate  11008   a . More specifically, the tail  10314  ( FIGS.  104 A and  107 A ) may be extended through the channel  11006  and the flag  10416  may be bent generally orthogonal to the tail  10314  and coupled to the underlying first adhesive substrate  11008   a.    
     Referring now to  FIG.  110 B , in a fifth step of the process  10900 , a printed circuit board (PCB)  11010  may be positioned on the base substrate  10904  and about the sensor holder  11004 . The PCB  11010  may be similar in some respects to the PCB  10408  of  FIGS.  104 A and  107 A , and may thus include a plurality of electronic modules  11012  mounted thereto. The electronic modules  11012  may include one or both of a Bluetooth antenna and a near field communication (NFC) antenna. As illustrated, the PCB  11010  may define two opposing lobes  11014   a  and  11014   b  interconnected by a neck portion  11016 . Opposing battery contacts  11018   a  and  11018   b  may be provided on the opposing lobes  11014   a,b  to facilitate electrical communication with a battery  11020 . 
     In a sixth step of the process  10900 , a second adhesive substrate  11008   b  may be applied to the first battery contact  11018   a  in preparation for receiving the battery  11020  in an adjacent seventh step of the process  10900 . The second adhesive substrate  11008   b  may comprise a pressure-adhesive tape used to couple the battery  11020  to the first battery contact  11018   a . The second adhesive substrate  11008   b , however, may also comprise a Z-axis anisotropic (or conductive) pressure-adhesive tape that also facilitates electrical communication (i.e., transfer of electrical power) between the battery  11020  and the first battery contact  11018   a.    
     Referring now to  FIG.  110 C , in an eighth step of the process  10900 , a filler  11022  may be positioned or arranged on the first lobe  11014   a  of the PCB  11010 . The filler  11022  may be the same as or similar to the filler  10426  of  FIG.  104 B or  107 B , and may thus comprise foam made of a low-density polyethylene or polyolefin. Moreover, the filler  11022  may be die cut and/or molded to fit around one or both of the battery  11020  and the sensor holder  11004 . In the illustrated embodiment, the filler  11022  may define apertures  11024   a  and  11024   b  to receive the battery  11020  and/or the sensor holder  11004 . The filler  11022  may also operate as a potting material that takes up space that would otherwise be occupied by air, and thus help to stabilize the electronic modules  11012  ( FIG.  110 B ) of the PCB  11010  and mitigate damaging vibration. 
     In a ninth step of the process  10900 , a third adhesive substrate  11008   c  may be applied to a top of the filler  11022  to help couple the second lobe  11014   b  of the PCB  11010  to the top of the filler  11022  in a subsequent step of the process  10900 . The third adhesive substrate  11008   c  may comprise a pressure-adhesive tape, but may also comprise a Z-axis anisotropic (or conductive) pressure-adhesive tape that also facilitates electrical communication (i.e., transfer of electrical power) between the battery  11020  and the second battery contact  11018   b . The third adhesive substrate  11008   c  may also facilitate electrical communication between the sensor contacts  10422  provided on the sensor  10316  and corresponding circuitry contacts  11026  (three shown) included on the PCB  11010 . 
     Referring now to  FIG.  110 D , in a tenth step of the process  10900 , the second lobe  11014   b  of the PCB  11010  may be folded down at the neck  11016  to couple the PCB  11010  to the filler  11022 . Coupling the PCB  11010  to the filler  11022  may also complete the conductive pathway via the third adhesive substrate  11008   c  between the battery  11020  and the second battery contact  11018   b , and between the sensor contacts  10422  and the corresponding circuitry contacts  11026 . 
     In an eleventh step of the process  10900 , a fourth adhesive substrate  11008   d  may be applied to a portion of the top of the second lobe  11014   b  of the PCB  11010 . The fourth adhesive substrate  11008   d  may also comprise a pressure-adhesive tape, and may be used to couple an upper cover  11028  to the PCB  11010 , as provided in a twelfth step of the process  10900 . The upper cover  11028  may be the same as or similar to the upper cover  10306  of  FIGS.  103  and  106   , and the fourth adhesive substrate  11008   d  may help secure the upper cover  10306  to the PCB  11010 . 
     In some embodiments, the upper cover  11028  may be provided by another roll of material continuously provided to the web-based assembly in the process  10900 . In some embodiments, the upper cover  11028  may be vacuum-formed, but could alternatively, be cold formed or injection molded, without departing from the scope of the disclosure. Accordingly, as indicated above, this web-based process  10900  may include or exclude injection molded parts, such as for the upper or lower covers  10306 ,  10308 . In some embodiments, the upper cover  11028  may be formed or defined to provide a flange  11030  about its periphery, and the flange  11030  may provide a location to seal the upper cover  11028  to the base substrate  10904  (i.e., the “lower cover”). The upper cover  11028  may be secured to the base substrate  10904  via one or more of sonic welding, ultrasonic welding, laser welding, photonic flash soldering, heat sealing, an adhesive substrate (e.g., a pressure sensitive adhesive or tape), or any combination thereof. Alternatively, the fourth adhesive substrate  11008   d  may sufficiently couple the upper cover  11028  to the base substrate  10904 , or an additional adhesive substrate (not shown) may be applied at the flange  11030  to secure the upper cover  11028  to the base substrate  10904 , without departing from the scope of the disclosure. 
     Referring now to  FIG.  110 E , in a thirteenth step of the process  10900 , the outer diameter of the sensor control device  10902  may be trimmed to remove the excess portions of the base substrate  10904  ( FIGS.  110 A and  110 D ). In some embodiments, as illustrated, the sensor control device  10902  may have a substantially circular cross-section, but could alternatively comprise any other cross-sectional shape, such as polygonal, oval, ovoid (e.g., pill- or egg-shaped), a squircle, or any combination thereof, without departing from the scope of the disclosure. 
     In a fourteenth and final step of the process  10900 , the plug assembly  10310  as described herein may be received by the sensor control device  10902  by extending the sharp  10318  through the sensor control device  10902  until the sharp hub  10320  engages a top surface of the sensor control device  10902 . As the sharp  10318  extends through the sensor control device  10902 , the sensor  10316  may be received within a hollow or recessed portion of the sharp  10318 . 
       FIG.  111 A  is a top view of the sensor control device  10902  in preparation for pressure testing and/or vacuum sealing, according to one or more embodiments. In the illustrated embodiment, a web  11102  may form part of or otherwise extend from the sensor control device  10902  across a tab section  11104 . The tab section  11104  may form part of the flange  11030  or may otherwise extend therefrom. The web  11102  may comprise two layers of film  11106   a  and  11106   b . In some embodiments, for instance, the upper layer  11106   a  may be connected to or form part of the material that forms the upper cover  11028 , as described above with reference to  FIGS.  110 D and  110 E , and the lower layer  11106   b  may be connected to or form part of the base material  10904 , as described above with reference to  FIGS.  109 ,  110 A and  110 D . 
     An aperture  11108  may be defined through the upper layer  11106   a  (or the lower layer  11106   b ) to facilitate fluid communication between the two layers  11106   a,b  and the interior of the sensor control device  10902 . A seal  11110  may be made about the periphery of the web  11102  to seal the upper and lower layers  11106   a,b  together. Moreover, the flange  11030  may be sealed about the periphery of the sensor control device  10902  except across the tab section  11104 , thus facilitating fluid communication into and/or out of the sensor control device via the web  11102 . In some embodiments, one or both of the upper and lower layers  11106   a,b  may provide or otherwise define a pattern or web of interconnected channels  11112  that help facilitate fluid communication between the aperture  11108  and the interior of the sensor control device  10902  via the tab section  11104 . 
     By injecting air (or another fluid) into the sensor control device  10902  via the aperture  11108  and the web  11102 , the sensor control device  10902  may be pressure tested to determine if the outer periphery (e.g., the flange  11030 ) or other portions of the sensor control device  10902  are properly sealed. This is often referred to as “pressure decay testing,” and helps verify seal integrity of medical devices made of layers of film. Alternatively, air may be evacuated from the sensor control device  10902  via the aperture  11108  and the web  11102  to place the interior of the sensor control device  10902  under vacuum conditions. The channels  11112  may prove advantageous in helping to draw the vacuum without entirely collapsing the upper and lower layers  11106   a,b.    
       FIG.  111 B  is a cross-sectional side view of the sensor control device  10902  with a compressor  11114 . The compressor  11114  may have proper fittings to fluidly couple to the web  11102  via the aperture  11108 . In some embodiments, the compressor  11114  may be arranged on a back support  11116  to help support the pressure fitting at the aperture  11108 . 
     To pressure test the sensor control device  10902  to determine if it meets pressure requirements, the compressor  11114  may inject air into the web  11102  via the aperture  11108 , and the air may circulate to the interior of the sensor control device  10902  between the opposing layers  11106   a,b  and via the tab section  11104 . This allows seal integrity testing to be performed during the manufacturing process of the sensor control device  10902 . Once the seal integrity is verified, the periphery of the sensor control device  10902  at the tab section  11104  may be sealed and the web  11102  may be trimmed from the sensor control device  10902 . 
     In some embodiments, after the sensor control device  10902  has been pressure tested, operation of the compressor  11114  may be reversed to pull a vacuum on the sensor control device  10902 , as indicated above. Once the vacuum is drawn, the periphery of the sensor control device  10902  at the tab section  11104  may be sealed, thus leaving the sensor control device  10902  under vacuum conditions. As will be appreciated, vacuum conditions may prove advantageous since the sensor control device  10902  may be transported through high altitudes, where a non-vacuum sealed device would have a tendency to expand or “pillow” out. Moreover, the vacuum may be drawn during the manufacturing process, following which the web  11102  may be trimmed from the sensor control device  10902 . 
       FIG.  112    is a partial cross-sectional side view of an example sensor control device  11200 , according to one or more embodiments. The sensor control device  11200  may be similar in some respects to any of the sensor control devices described herein. As illustrated, the sensor control device  11200  may include a housing  11202  configured to house electronic modules or components used to operate the sensor control device. Example electronic modules include, but are not limited to a battery, a data processing unit (e.g., an application specific integrated circuit or ASIC), a resistor, a transistor, a capacitor, an inductor, a diode, and a switch. 
     The sensor control device  11200  may further include a sensor  11204  and a sharp  11206 , which may be similar to any of the sensors and sharps described herein. Consequently, the sharp  11206  may be used to help transcutaneously implant the sensor  11204  beneath a user&#39;s skin for monitoring blood glucose levels. In the illustrated embodiment, the sensor  11204  and the sharp  11206  are arranged within a sterile chamber  11208  to protect the sensor  11204  and the sharp  11206  from external contamination. In some embodiments, the sterile chamber  11208  may have a desiccant arranged therein to help promote preferred humidity conditions. 
     In some embodiments, the sensor  11204  and the sharp  11206  may be sterilized while assembled within the sensor control device  11200 . In at least one embodiment, the sensor  11204  and the sharp  11206  may be subjected to radiation sterilization to properly sterilize the sensor  11204  and the sharp  11206  for use. Suitable radiation sterilization processes include, but are not limited to, electron beam (e-beam) irradiation, gamma ray irradiation, X-ray irradiation, or any combination thereof. 
     In some embodiments, the sterile chamber  11208  may comprise a cap that provides a sealed barrier that protects exposed portions of the sensor  11204  and the sharp  11206  until placed in use. In such embodiments, the sterile chamber  11208  may be removable or detachable to expose the sensor  11204  and the sharp  11206 , as described below. Moreover, in such embodiments, the cap may be made of a material that permits propagation of radiation therethrough to facilitate radiation sterilization of the sensor  11204  and the sharp  11206 . Suitable materials for the sterile chamber  11208  include, but are not limited to, a non-magnetic metal (e.g., aluminum, copper, gold, silver, etc.), a thermoplastic, ceramic, rubber (e.g., ebonite), a composite material (e.g., fiberglass, carbon fiber reinforced polymer, etc.), an epoxy, or any combination thereof. In some embodiments, the sterile chamber  11208  may be transparent or translucent, but can otherwise be opaque, without departing from the scope of the disclosure. 
     In other embodiments, the sterile chamber  11208  may comprise a chamber or compartment defined within the sensor control device  11200 . In such embodiments, the sterile chamber  11208  may include a microbial barrier positioned at one or both ends of the sterile chamber  11208 . More specifically, the sterile chamber  11208  may provide or include an upper microbial barrier  11210   a  and a lower microbial barrier  11210   b  opposite the upper microbial barrier  11210   a . The upper and lower microbial barriers  11210   a,b  may help seal the sterile chamber  11208  to thereby isolate the sensor  11204  and the sharp  11206  from external contamination. The microbial barriers  11210   a,b  may be made of a radiation permeable material, such as a synthetic material (e.g., a flash-spun high-density polyethylene fiber). One example synthetic material comprises TYVEK®, available from DuPont®. In other embodiments, however, the microbial barriers  11210   a,b  may comprise, but are not limited to, tape, paper, film, foil, or any combination thereof. 
     In some embodiments, the sensor  11204  and the sharp  11206  may be deployable and otherwise movable relative to the sensor control device  11200 . In such embodiments, the sensor  11204  and the sharp  11206  may be advanced distally out of the sterile chamber  11208  and past the bottom of the housing  11202  to allow the sensor  11204  and the sharp  11206  to be transcutaneously received beneath a user&#39;s skin. Distally advancing the sensor  11204  and the sharp  11206  may be accomplished via a variety of mechanical or electromechancial means. In some embodiments, for example, the sensor control device  11200  may include a pusher  11212  configured to advance to push the sensor  11204  and the sharp  11206  out of the sterile chamber  11208 . In such embodiments, the pusher  11212  may also be configured to attach to the sharp  11206  and subsequently retract the sharp  11206  while leaving the sensor  11204  extended. During operation, the pusher  11212  may penetrate the upper microbial barrier  11210   a  and force the sensor  11204  and the sharp  11206  distally through the lower microbial barrier  11210   b.    
     As illustrated, the pusher  11212  may comprise a flexible shaft that extends within a curved pathway  11214  defined laterally through the housing  11202  and does not penetrate the top of the housing  11202 . The pathway  11214  may terminate at or near an upper end of the sterile chamber  11208 . In at least one embodiment, as illustrated, the pusher  11212  may extend out of the housing  11202  at a sidewall  11216  thereof. In such embodiments, actuation of the pusher  11212  may originate at the location of the sidewall  11216  to advance or retract the pusher  11212  within the pathway  11214  and thereby act on the sterile chamber  11208  and/or the sensor  11204 , and the sharp  11206 . 
     In embodiments where the sterile chamber  11208  comprises a cap, the pusher  11212  may be operable to discharge or push the cap out of the sensor control device  11200 . In such embodiments, a user may commence the firing process by priming the sensor control device  11200 , which may cause the cap to be discharged from the sensor control device  11200 . Further actuation of the sensor control device  11200  by the user may cause the sensor  11204  and the sharp  11206  to be fully extended for subcutaneous implantation. In other embodiments, the cap may be removed either autonomously (e.g., it falls off or breaks away during firing) or the user may manually remove it by hand. 
       FIG.  113    is a cross-sectional side view of an example sensor applicator  11300 , according to one or more embodiments. The sensor applicator  11300  may be similar in some respects to any of the sensor applicators described herein. Accordingly, the sensor applicator  11300  may be configured to house a sensor control device  11302  and may be operable to deploy the sensor control device  11302  to a target monitoring location. The sensor control device  11302  may be similar in some respects to any of the sensor control devices described herein. As illustrated, the sensor control device  11302  may include an electronics housing  11304  configured to house electronic modules or components used to operate the sensor control device  11302 . The sensor control device  11302  may further include a sensor  11306  and a sharp  11308 , which may be similar to any of the sensors and sharps described herein. Consequently, the sharp  11308  may be used to help transcutaneously implant the sensor  11306  beneath a user&#39;s skin for monitoring blood glucose levels. 
     In the illustrated embodiment, the sensor applicator includes a housing  11310  and an applicator cap  11312  removably coupled to the housing  11310 . The applicator cap  11312  may be threaded to the housing  11310  and may be removed by rotating (e.g., unscrewing) the applicator cap  11312  relative to the housing  11310 . 
     In the illustrated embodiment, the sensor applicator  11300  may include a filler  11314  arranged at least partially within the applicator cap  11312 . In some embodiments, the filler  11314  may form an integral part or extension of the applicator cap  11312 , such as being molded with or overmolded onto the applicator cap  11312 . In other embodiments, the filler  11314  may comprise a separate structure fitted within or attached to the applicator cap  11312 , without departing from the scope of the disclosure. In some embodiments, the filler  11314  may generally help support the sensor control device  11302  while contained within the sensor applicator  11302 . 
     The filler  11314  may define or otherwise provide a sterilization zone  11316  configured to receive the sensor  11306  and the sharp  11308  as extending from the bottom of the electronics housing  11304 . The sterilization zone  11316  may generally comprise a hole or passageway extending at least partially through the body of the filler  11314 . When the sensor control device  11302  is loaded into the sensor applicator  11302  and the applicator cap  11312  is secured thereto, the sensor  11306  and the sharp  11308  may be positioned within the sterilization zone  11316  of the filler  11314 , which may be sealed to isolate the sensor  11306  and the sharp  11308  from external contamination. 
     The applicator cap  11312  and the filler  11314  may each be made of a gas impermeable material, such as a plastic or polycarbonate. Moreover, a gasket  11318  may be located at an interface between the filler  11314  and the bottom of the electronics housing  11304  to generate a gas-tight seal. In some embodiments, the gasket  11318  may be overmolded onto the filler  11314  or alternatively onto the bottom of the electronics housing  11304 . In other embodiments, however, the gasket  11318  may comprise a separate component part or seal, such as an O-ring or the like. 
     While the sensor control device  11302  is positioned within the sensor applicator  11302 , the sensor  11306  and the sharp  11308  may be sterilized. According to the present embodiment, sterilizing the sensor  11306  and the sharp  11308  may be accomplished by introducing a sterilizing gas  11320  into the sterilization zone  11316 . The sterilizing gas  11320  may comprise, for example, nitrogen dioxide (NO 2 ), which operates to sterilize the sensor  11306  and the sharp  11308  without adversely affecting the chemistry on the sensor  11306 . Moreover, the gasket  11318  may prevent the sterilizing gas  11320  from migrating laterally out of the sterilization zone  11316  and impinging upon and damaging an adhesive layer  11322  attached to the bottom of the electronics housing  11304 . Accordingly, the sterilization zone  11316  allows transmission of the sterilizing gas  11320  to impinge upon and sterilize the sensor  11306  and the sharp  11308 , while the remaining portions of the filler  11314  and the gasket  11318  prevent (impede) the sterilizing gas  11320  from damaging the integrity of the adhesive layer  11322 . 
     In some embodiments, a microbial barrier  11324  may be applied to the end of the filler  11314  and/or the applicator cap  11312  to seal off the sterilization zone  11316 . In some embodiments, the microbial barrier  11324  may comprise two or more layers of different materials. The first layer may be made of a synthetic material (e.g., a flash-spun high-density polyethylene fiber), such as Tyvek® available from DuPont®. Tyvek® is highly durable and puncture resistant and allows the permeation of vapors and gases. The Tyvek® layer can be applied before or after application of the sterilizing gas  11320 , and following the sterilizing process, a foil or other vapor and moisture resistant material layer may be sealed (e.g., heat sealed) over the Tyvek® layer to prevent the ingress of contaminants and moisture into the sterilization zone  11316 . In other embodiments, the microbial barrier  11324  may comprise only a single protective layer applied to the end of the filler  11314 . In such embodiments, the single layer is gas permeable for the sterilization process, but is also capable of protection against moisture and other harmful elements once the sterilization process is complete. Accordingly, the microbial barrier  11324  may operate as a moisture and contaminant layer, without departing from the scope of the disclosure. 
     It is noted that, while the sensor  11306  and the sharp  11308  extend from the bottom of the electronics housing  11304  and into the sterilization zone  11316  generally concentric with a centerline of the sensor applicator  11302  and the applicator cap  11312 , it is contemplated herein to have an eccentric arrangement. More specifically, in at least one embodiment, the sensor  11306  and the sharp  11308  may extend from the bottom of the electronics housing  11304  eccentric to the centerline of the sensor applicator  11302  and the applicator cap  11312 . In such embodiments, the filler  11314  may be re-designed and otherwise configured such that the sterilization zone  11316  is also eccentrically positioned to receive the sensor  11306  and the sharp  11308 , without departing from the scope of the disclosure. 
     Embodiments disclosed herein include: 
     HH. A sensor control device that includes an electronics housing including an upper cover securable to a lower cover, a sensor electronics module positionable between the upper and lower covers and including a sensor holder defining a channel, a sensor including a tail extendable through the channel and a flag that includes one or more sensor contacts, a printed circuit board (PCB) having one or more circuitry contacts alignable with the one or more sensor contacts, a first adhesive substrate interposing the flag and the sensor holder to secure the sensor to the sensor holder, and a second adhesive substrate interposing the flag and the PCB to secure the sensor to the PCB and facilitate electrical communication between the one or more sensor contacts and the one or more circuitry contacts. The sensor control device further includes a sharp extendable through the electronics housing, wherein the sharp and the tail extend from a bottom of the electronics housing. 
     II. A converting process of fabricating a sensor control device that includes positioning a sensor holder defining a channel on a base substrate, extending a tail of a sensor through the channel and securing a flag of the sensor to the sensor holder with a first adhesive substrate applied to a top of the sensor holder, wherein the flag includes one or more sensor contacts, positioning a printed circuit board (PCB) on the base substrate and about the sensor holder, the PCB providing one or more circuitry contacts alignable with the one or more sensor contacts, attaching the PCB to the flag with a second adhesive substrate applied to a top of the flag, facilitating electrical communication between the one or more sensor contacts and the one or more circuitry contacts with the second adhesive substrate, positioning an upper cover over the PCB and securing the upper cover to the base substrate to form an electronics housing, trimming the base substrate about an outer periphery of the electronics housing, and extending a sharp through the electronics housing, wherein the sharp and the tail extend from a bottom of the electronics housing. 
     Each of embodiments HH and II may have one or more of the following additional elements in any combination: Element 1: further comprising a filler positionable between the upper and lower covers with the sensor electronics module. Element 2: further comprising a third adhesive substrate interposing the lower cover and the filler to secure the filler to the lower cover. Element 3: wherein the sensor electronics module further includes a cap matable with the sensor holder to help secure the sensor within the sensor electronics module. Element 4: wherein the sensor electronics module further includes a third adhesive substrate interposing the cap and the PCB to secure the cap to the PCB. Element 5: wherein the sensor holder is matable with the PCB. Element 6: wherein one or both of the upper and lower covers are made of a material selected from the group consisting of a film, a foil, a foam, a laminated material, and any combination thereof. Element 7: wherein one or both of the upper and lower covers are formed by a manufacturing process selected from the group consisting of thermoforming, vacuum forming, injection molding, die-cutting, stamping, compression molding, transfer molding, and any combination thereof. Element 8: wherein the upper cover is secured to the lower cover via at least one of sonic welding, ultrasonic welding, laser welding, heat sealing, an adhesive substrate, and any combination thereof. 
     Element 9: wherein the base substrate comprises a film of material disposed on a roll, and attaching the sensor holder to the base substrate is preceded by unrolling the base substrate from the roll, and forming a hole in the base substrate. Element 10: wherein positioning the sensor holder on the base substrate comprises securing the sensor holder to the base substrate using at least one of ultrasonic welding, heat sealing, an adhesive substrate, and any combination thereof. Element 11: wherein the PCB defines first and second lobes interconnected by a neck portion and the one or more circuitry contacts are provided on the second lobe, and wherein attaching the PCB to the flag comprises folding the second lobe onto the first lobe at the neck portion, and aligning the one or more circuitry contacts with the one or more sensor contacts. Element 12: wherein each lobe provides a battery contact, and the method further comprises applying a third adhesive substrate to the battery contact on the first lobe, attaching a battery to the third adhesive substrate, wherein the second adhesive substrate is further applied to a top of the battery, and folding the second lobe onto the first lobe to align the battery contact on the second lobe with the top of the battery, wherein the second and third adhesive substrates comprise Z-axis anisotropic pressure-adhesive tapes that facilitate electrical communication between the battery and the battery contacts. Element 13: further comprising positioning a filler on the PCB and about the sensor holder, and mitigating vibration and stabilizing electronic modules of the PCB with the filler. Element 14: further comprising applying a third adhesive substrate between the PCB and the upper cover to secure the upper cover to the PCB. Element 15: wherein positioning the upper cover over the PCB comprises forming the upper cover using a process selected from the group consisting of thermoforming, cold forming, vacuum forming, injection molding, die-cutting, stamping, and any combination thereof. Element 16: wherein securing the upper cover to the base substrate comprises sealing the upper cover to the base substrate using a process selected from the group consisting of sonic welding, ultrasonic welding, laser welding, heat sealing, using an adhesive substrate, and any combination thereof. Element 17: further comprising forming a web extending from the outer periphery of the electronics housing and across a tab section, the web providing upper and lower layers sealed at a periphery, facilitating fluid communication into an interior of the electronics housing via the web and an aperture defined in the upper layer, and pressure testing the electronics housing by injecting air into the electronics housing via the aperture and the web. Element 18: further comprising extracting air from the interior of the electronics housing via the web and the aperture, and sealing the outer periphery of the electronics housing under vacuum conditions. 
     By way of non-limiting example, exemplary combinations applicable to HH and II include: Element 1 with Element 2; Element 3 with Element 4; Element 11 with Element 12; and Element 17 with Element 18. 
     Example Embodiments of Sensor Module and Plug 
       FIGS.  114 A and  114 B  are top and bottom perspective views, respectively, of an example embodiment of the plug  2702  of  FIGS.  27 A- 27 B , according to one or more embodiments. As described above, the plug  2702  may be designed to hold the connector  2704  (FIGS.  FIGS.  27 A- 27 B and  115 A- 115 B ) and the sensor  2616  ( FIGS.  27 B and  116   ). The plug  2702  is capable of being securely coupled with the electronics housing  2604  ( FIGS.  26 A- 26 B ), and the deflectable arms  2707  are configured to snap into corresponding features provided on the bottom of the electronics housing  2604 . The sharp slot  2706  can provide a location for the sharp tip  2726  ( FIG.  27 B ) to pass through and the sharp shaft  2724  ( FIGS.  27 A- 27 B ) to temporarily reside. As illustrated, a sensor ledge  11402  can define a sensor position in a horizontal plane, prevent a sensor from lifting the connector  2704  off of connector posts  11404  and maintain the sensor  2616  parallel to a plane of connector seals. It can also define sensor bend geometry and minimum bend radius. It can limit sensor travel in a vertical direction and prevent a tower from protruding above an electronics housing surface and define a sensor tail length below a patch surface. A sensor wall  11406  can constrain the sensor  2616  and define a sensor bend geometry and minimum bend radius. 
       FIGS.  115 A and  115 B  are perspective views depicting an example embodiment of the connector  2704  in open and closed states, respectively. The connector  2704  can be made of silicone rubber that encapsulates compliant carbon impregnated polymer modules that serve as the electrical conductive contacts  2720  between the sensor  2616  ( FIGS.  27 B and  116   ) and electrical circuitry contacts for the electronics within housing  2604 . The connector  2704  can also serve as a moisture barrier for the sensor  2616  when assembled in a compressed state after transfer from a container to an applicator and after application to a user&#39;s skin. A plurality of seal surfaces  11502  can provide a watertight seal for electrical contacts and sensor contacts. The hinges  2718  connect two distal and proximal portions of the connector  2704 . 
       FIG.  116    is a perspective view of an example embodiment of the sensor  2616 . The neck  2712  can be a zone which allows folding of the sensor  2616 , for example ninety degrees. A membrane on the tail  2708  can cover an active analyte sensing element of the sensor  2616 . The tail  2708  can be the portion of the sensor  2616  that resides under a user&#39;s skin after insertion. The flag  2710  includes the contacts  2714  and also provides a sealing surface. A biasing tower  11602  can be a tab that biases the tail  2708  into the sharp slot  2706  ( FIGS.  114 A- 114 B ). A bias fulcrum  11604  can be an offshoot of the biasing tower  11602  that contacts an inner surface of a needle to bias the tail  2708  into a slot defined by the sharp. A bias adjuster  11606  can reduce a localized bending of a tail connection and prevent sensor trace damage. The contacts  2714  can electrically couple the active portion of the sensor to the connector  2704 , and a service loop  11608  can translate an electrical path from a vertical direction ninety degrees and engage with the sensor ledge  11402  ( FIG.  114 B ). 
       FIGS.  117 A and  117 B  are bottom and top perspective views, respectively, depicting an example embodiment of a sensor module assembly comprising the sensor plug  2702 , the connector  2704 , and the sensor  2616 . According to one aspect of the aforementioned embodiments, during or after insertion, the sensor  2616  can be subject to axial forces pushing up in a proximal direction against the sensor  2616  and into the sensor module, as shown by force F 1  of  FIG.  15 A . According to some embodiments, this can result in an adverse force F 2  being applied to neck  2712  of the sensor  2616  and, consequently, result in adverse forces F 3  being translated to service loop  11608  of the sensor  2616 . In some embodiments, for example, axial forces F 1  can occur as a result of a sensor insertion mechanism in which the sensor is designed to push itself through the tissue, a sharp retraction mechanism during insertion, or due to a physiological reaction created by tissue surrounding sensor  2616  (e.g., after insertion). 
       FIGS.  118 A and  118 B  are close-up partial views of an example embodiment of the sensor plug  2702  having certain axial stiffening features. In a general sense, the embodiments described herein are directed to mitigating the effects of axial forces on the sensor  2616  as a result of insertion and/or retraction mechanisms, or from a physiological reaction to the sensor in the body. As illustrated, the sensor  2616  comprises a proximal portion having a hook feature  11802  configured to engage a catch feature  11804  of the plug  2702 . In some embodiments, the plug  2702  can also include a clearance area  11806  to allow a distal portion of the sensor  2616  to swing backwards during assembly to allow for the assembly of the hook feature  11802  of the sensor  2616  over and into the catch feature  11804  of the plug  2702 . 
     According to another aspect of the embodiments, the hook and catch features  11802 ,  11084  operate in the following manner. The sensor  2616  includes a proximal sensor portion, coupled to the plug  2702 , as described above, and a distal sensor portion that is positioned beneath a skin surface in contact with a bodily fluid. The proximal sensor portion may include the hook feature  11802  adjacent to the catch feature  11804  of the plug  2702 . During or after sensor insertion, one or more forces are exerted in a proximal direction along a longitudinal axis of the sensor  2616 . In response to the one or more forces, the hook feature  11802  engages the catch feature  11804  to prevent displacement of the sensor  2616  in a proximal direction along the longitudinal axis. 
     According to another aspect of the disclosure, the sensor  2616  can be assembled with the plug  2702  in the following manner. The sensor  2616  is loaded into the plug  2702  by displacing the proximal sensor portion in a lateral direction to bring the hook feature  11802  in proximity to the catch feature  11804  of the plug  2702 . More specifically, displacing the proximal sensor portion in a lateral direction causes the proximal sensor portion to move into the clearance area  11806  of the plug  2702 . 
     Although  FIGS.  118 A and  118 B  depict the hook feature  11802  as a part of the sensor  2616 , and the catch feature  11804  as a part of the plug  2702 , those of skill in the art will appreciate that the hook feature  11802  can instead be a part of the plug  2702 , and, likewise, the catch feature  11804  can instead be a part of the sensor  3106 . Similarly, those of skill in the art will also recognize that other mechanisms (e.g., detent, latch, fastener, screw, etc.) implemented on the sensor  2616  and the plug  2702  to prevent axial displacement of sensor  2616  are possible and within the scope of the present disclosure. 
       FIG.  119    is a side view of an example sensor  11900 , according to one or more embodiments of the disclosure. The sensor  11900  may be similar in some respects to any of the sensors described herein and, therefore, may be used in an analyte monitoring system to detect specific analyte concentrations. As illustrated, the sensor  11900  includes a tail  11902 , a flag  11904 , and a neck  11906  that interconnects the tail  11902  and the flag  11904 . The tail  11902  includes an enzyme or other chemistry or biologic and, in some embodiments, a membrane may cover the chemistry. In use, the tail  11902  is transcutaneously received beneath a user&#39;s skin, and the chemistry included thereon helps facilitate analyte monitoring in the presence of bodily fluids. 
     The tail  11902  may be received within a hollow or recessed portion (e.g., the recessed portion  2728  of  FIG.  27 B ) of a sharp (not shown) to at least partially circumscribe the tail  11902  of the sensor  11900 . As illustrated, the tail  11902  may extend at an angle Θ offset from horizontal. In some embodiments, the angle Θ may be about 85°. Accordingly, in contrast to other sensor tails, the tail  11902  may not extend perpendicularly from the flag  11904 , but instead at an angle offset from perpendicular. This may prove advantageous in helping maintain the tail  11902  within the keep the recessed portion of the sharp. 
     The tail  11902  includes a first or bottom end  11908   a  and a second or top end  11908   b  opposite the top end  11908   a . A tower  11910  may be provided at or near the top end  11908   b  and may extend vertically upward from the location where the neck  11906  interconnects the tail  11902  to the flag  11904 . During operation, if the sharp moves laterally, the tower  11910  will help picot the tail  11902  toward the sharp and otherwise stay within the recessed portion (e.g., the recessed portion  2728  of  FIG.  27 B ) of the sharp. Moreover, in some embodiments, the tower  11910  may provide or otherwise define a protrusion  11912  that extends laterally therefrom. When the sensor  11900  is mated with the sharp and the tail  11902  extends within the recessed portion of the sharp, the protrusion  11912  may engage the inner surface of the recessed portion. In operation, the protrusion  11912  may help keep the tail  11902  within the recessed portion. 
     The flag  11904  may comprise a generally planar surface having one or more sensor contacts  11914  arranged thereon. The sensor contact(s)  11914  may be configured to align with a corresponding number of compliant carbon impregnated polymer modules encapsulated within a connector. 
     In some embodiments, as illustrated, the neck  11906  may provide or otherwise define a dip or bend  11916  extending between the flag  11904  and the tail  11902 . The bend  11916  may prove advantageous in adding flexibility to the sensor  11900  and helping prevent bending of the neck  11906 . 
     In some embodiments, a notch  11918  (shown in dashed lines) may optionally be defined in the flag near the neck  11906 . The notch  11918  may add flexibility and tolerance to the sensor  11900  as the sensor  11900  is mounted to the mount. More specifically, the notch  11918  may help take up interference forces that may occur as the sensor  11900  is mounted within the mount. 
       FIGS.  120 A and  120 B  are isometric and partially exploded isometric views of an example connector assembly  12000 , according to one or more embodiments. As illustrated, the connector assembly  12000  may include a connector  12002 , and  FIG.  120 C  is an isometric bottom view of the connector  12002 . The connector  12002  may comprise an injection molded part used to help secure one or more compliant carbon impregnated polymer modules  12004  (four shown in  FIG.  120 B ) to a mount  12006 . More specifically, the connector  12002  may help secure the modules  12004  in place adjacent the sensor  11900  and in contact with the sensor contacts  11914  ( FIG.  119   ) provided on the flag  11904  ( FIG.  119   ). The modules  12004  may be made of a conductive material to provide conductive communication between the sensor  11900  and corresponding circuitry contacts (not shown) provided within the mount  12006 . 
     As best seen in  FIG.  120 C , the connector  12002  may define pockets  12008  sized to receive the modules  12004 . Moreover, in some embodiments, the connector  12002  may further define one or more depressions  12010  configured to mate with one or more corresponding flanges  12012  ( FIG.  120 B ) on the mount  12006 . Mating the depressions  12010  with the flanges  12012  may secure the connector  12002  to the mount  12006  via an interference fit or the like. In other embodiments, the connector  12002  may be secured to the mount  12006  using an adhesive or via sonic welding. 
       FIGS.  121 A and  121 B  are isometric and partially exploded isometric views of another example connector assembly  12100 , according to one or more embodiments. As illustrated, the connector assembly  12100  may include a connector  12102 , and  FIG.  121 C  is an isometric bottom view of the connector  12102 . The connector  12102  may comprise an injection molded part used to help keep one or more compliant metal contacts  12104  (four shown in  FIG.  121 B ) secured against the sensor  11900  on a mount  12106 . More specifically, the connector  12102  may help secure the contacts  12104  in place adjacent the sensor  11900  and in contact with the sensor contacts  11914  ( FIG.  119   ) provided on the flag  11904 . The contacts  12104  may be made of a stamped conductive material that provides conductive communication between the sensor  11900  and corresponding circuitry contacts (not shown) provided within the mount  12106 . In some embodiments, for example, the contacts  12104  may be soldered to a PCB (not shown) arranged within the mount  12106 . 
     As best seen in  FIG.  121 C , the connector  12102  may define pockets  12108  sized to receive the contacts  12104 . Moreover, in some embodiments, the connector  12102  may further define one or more depressions  12110  configured to mate with one or more corresponding flanges  12112  ( FIG.  120 B ) on the mount  12006 . Mating the depressions  12110  with the flanges  12112  may help secure the connector  12102  to the mount  12106  via an interference fit or the like. In other embodiments, the connector  12102  may be secured to the mount  12106  using an adhesive or via sonic welding. 
     Therefore, the disclosed systems and methods are well adapted to attain the ends and advantages mentioned as well as those that are inherent therein. The particular embodiments disclosed above are illustrative only, as the teachings of the present disclosure may be modified and practiced in different but equivalent manners apparent to those skilled in the art having the benefit of the teachings herein. Furthermore, no limitations are intended to the details of construction or design herein shown, other than as described in the claims below. It is therefore evident that the particular illustrative embodiments disclosed above may be altered, combined, or modified and all such variations are considered within the scope of the present disclosure. The systems and methods illustratively disclosed herein may suitably be practiced in the absence of any element that is not specifically disclosed herein and/or any optional element disclosed herein. While compositions and methods are described in terms of “comprising,” “containing,” or “including” various components or steps, the compositions and methods can also “consist essentially of” or “consist of” the various components and steps. All numbers and ranges disclosed above may vary by some amount. Whenever a numerical range with a lower limit and an upper limit is disclosed, any number and any included range falling within the range is specifically disclosed. In particular, every range of values (of the form, “from about a to about b,” or, equivalently, “from approximately a to b,” or, equivalently, “from approximately a-b”) disclosed herein is to be understood to set forth every number and range encompassed within the broader range of values. Also, the terms in the claims have their plain, ordinary meaning unless otherwise explicitly and clearly defined by the patentee. Moreover, the indefinite articles “a” or “an,” as used in the claims, are defined herein to mean one or more than one of the elements that it introduces. If there is any conflict in the usages of a word or term in this specification and one or more patent or other documents that may be incorporated herein by reference, the definitions that are consistent with this specification should be adopted. 
     As used herein, the phrase “at least one of” preceding a series of items, with the terms “and” or “or” to separate any of the items, modifies the list as a whole, rather than each member of the list (i.e., each item). The phrase “at least one of” allows a meaning that includes at least one of any one of the items, and/or at least one of any combination of the items, and/or at least one of each of the items. By way of example, the phrases “at least one of A, B, and C” or “at least one of A, B, or C” each refer to only A, only B, or only C; any combination of A, B, and C; and/or at least one of each of A, B, and C. 
     The use of directional terms such as above, below, upper, lower, upward, downward, left, and right and the like are used in relation to the illustrative embodiments as they are depicted in the figures, the upward direction being toward the top of the corresponding figure and the downward direction being toward the bottom of the corresponding figure.