Patent Publication Number: US-2002007155-A1

Title: Container for a medicinal liquid

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS  
     [0001] This application claims the benefit of Appl. No. 60/093,772, filed Jul. 23, 1998. 
    
    
     
       BACKGROUND OF THE INVENTION  
       [0002] 1. Field of the Invention  
       [0003] The present invention relates to a container for a medicinal liquid, more particularly to a container for a medicinal liquid, wherein the container is gas-tight and liquid-tight.  
       [0004] 2. Related Art  
       [0005] EP-0 182 094 A2 sets forth a bottle-shaped pack comprising an outer container which is stiff in respect of shape and an inner container which is disposed in the outer container and which is in the form of an easily deformable bag for containing the filling material. The preform is produced by co-extrusion of two coaxial tubular portions. The two portions comprise two thermoplastic materials which are not joined together. The preform is expanded in a blow molding mold. A welded seam is provided at the flat bottom of the inner container. The flat bottom which is formed on the outer container has an opening in the form of a slot. The outer container and the inner container are connected together in a positively locking relationship in the region of the discharge opening. That pack is produced substantially in one working operation.  
       [0006] The filling material is discharged from the container by means of a pump which is disposed in the discharge opening. The pump causes the inner container to deform as its volume decreases. Air passes into the space between the outer container and the deformed inner container, through the open slot in the flat bottom of the outer container, thereby preventing the occurrence of a reduced pressure in that intermediate space. The inner container does not involve a fixed contact with respect to the outer container, except in the region of the discharge to opening. The pack can be provided with a dip tube which extends almost as far as the flat bottom and which holds the inner container in the extended condition. That pack can be satisfactorily used and completely emptied, only when it is in a given position in space.  
       [0007] A tubular bag of composite foil is described in EP-0 620 165 A1. The composite foil comprises at least an outwardly disposed plastic foil and an inwardly disposed metal foil. The tubular bag is closed at both ends in a sack-like configuration. The bag is provided with a desired-rupture location, by means of which it can be reliably opened at that point. A tubular bag of that kind serves to store a hardenable material which is expelled from the tubular bag by means of an expelling device.  
       [0008] EP-0 068 653 A1 describes a flexible and collapsible container which is intended for one-trip use and which is made from a foil and which is used in a suction or feeding bottle which can be used a plurality of times. The one end of the container is open while the other end is closed by means of a welded seam and provided with a tongue portion. The tongue portion is clamped in a gap provided at the bottom of the suction or feeding bottle. That provides that the bag-like container is constantly held in an extended condition in the suction or feeding bottle.  
       SUMMARY OF THE INVENTION  
       [0009] The invention aims to make the production of a container which is intended for one-rip use more economical without adversely affecting its usefulness, and to simplify handling thereof.  
       [0010] The object of the present invention is to provide a container for a medicinal liquid, which is gas-tight and liquid-tight, and which has a filling volume that is suited to the intended purpose of use. The container plastically and irreversibly collapses under a slightly reduced pressure in a predetermined manner such that it can be substantially emptied.  
       [0011] The container of the present invention includes a foil bag which is closed at both ends. At a differential pressure between the interior of the container and its surroundings below 300 hPa (300 mbar), the foil bag is deformable by the external pressure and collapses. The container further includes a flange which is stable in respect of shape and which is sealingly mounted to the foil bag. The flange is a releasable connecting element for fitting the container on to a discharge connection member.  
       [0012] The foil bag is closed at at least one end with at least one welded seam which extends substantially transversely with respect to the axis of the bag. The flange has a sealing location which is stable in respect of shape. A discharge location for the liquid in the region of the flange is also provided, the discharge location being is stable in respect of shape.  
       [0013] The container of the present invention has several advantages over conventional containers. For example, the container of the present invention is economical to produce, is suitable for one-trip use and requires only a small amount of material usage.  
       [0014] Further, the container of the present invention can be produced in a sterile condition and filled and sealed in a sterile condition. It can also be used for medicaments intended for inhalation, which are typically provided as solutions in ethanol, water, or an ethanol and water mixture.  
       [0015] The liquid is discharged from the container of the present invention under sterile conditions, such that no air is sucked into the container upon discharge. As such, the liquid does not come into contact with air, oxygen or carbon dioxide.  
       [0016] Further, the container of the present invention permits gas and bubble-free discharge of the medicinal liquid.  
       [0017] The container of the present invention is sealed so that diffusion of liquids and gases is minimized. The container can be filled and then stored over several years, depending on the particular medicament involved, and still satisfy the requirements of all official pharmacopoeiae.  
       [0018] The container is easily deformable at a slightly reduced pressure. Further, in the collapsed condition the container of the present invention remains flat and stretched out, such that it retains its initial length after emptying.  
       [0019] Further, the container of the present invention does not require a valve for pressure equalization after a portion of the liquid has been discharged, and the container can be substantially emptied, even in a fluctuating position and when it is upside down.  
       [0020] The foil bag of the present invention is connected only to the flange which is stable in respect of shape and is not fixed to any casing, if such is provided.  
       [0021] The filling volume of the container can be easily adjusted to a predetermined value within a certain range by changing the length and/or the diameter of the foil bag. Further, the container can be filled prior to closure, before the single or the second welded seam is produced. As such, there is no need for a separate closure means.  
       [0022] The container can be used with or without a casing. If the container is disposed in a casing, it is protected from external damage.  
       [0023] The liquid is stored in the container of the present invention such that it is protected from the effect of light by an opaque foil bag or by an opaque casing which is closed all around.  
       [0024] Further, the container of the present invention can be fitted into and removed from a discharge device in a simple fashion and without rotary movement. 
     
    
    
     BRIEF DESCRIPTION OF THE FIGURES  
     [0025] The foregoing and other features and advantages of the invention will be apparent from the following, more particular description of a preferred embodiment of the invention, as illustrated in the accompanying drawings.  
     [0026]FIG. 1 is a perspective view of a first embodiment of a foil bag of the present invention which is closed at both ends.  
     [0027]FIG. 2 is a perspective view of a second embodiment of a foil bag of the present invention which is closed at both ends.  
     [0028]FIG. 3 is a perspective view of a third embodiment of a foil bag of the present invention which is closed at both ends.  
     [0029]FIG. 4 is a sectional view of a first embodiment of a flange of the present invention.  
     [0030]FIG. 5 a  is a sectional view of a second embodiment of a flange of the present invention.  
     [0031]FIG. 5 b  is a sectional view of the second embodiment of the flange taken along a line  5 - 5  of FIG. 5 a.    
     [0032]FIG. 6 is a sectional view of a third embodiment of a flange of the present invention.  
     [0033]FIG. 7 is a sectional view of a fourth embodiment of a flange of the present invention.  
     [0034]FIG. 8 a  is a view of a one-part flange of the present invention, which is disposed on the side of a foil bag.  
     [0035]FIG. 8 b  is an exploded view of a cross-section of laminate foil used to make up the foil bag of FIG. 8 a.    
     [0036]FIG. 9 a  is a side view of first embodiment of a welded seam of the present invention.  
     [0037]FIG. 9 b  is a sectional view of the welded seam taken along a line  9 - 9  of FIG. 9 a.    
     [0038]FIG. 10 a  is side view a second embodiment of a welded seam of the present invention.  
     [0039]FIG. 10 b  is a sectional view of the welded seam taken along a line  10 - 10  of FIG. 10 a.    
     [0040]FIG. 11 a  is a side view of a third embodiment of the welded seam of the present invention.  
     [0041]FIG. 11 b  is a plan view of the welded seam of FIG. 11 a.    
     [0042]FIGS. 12 a - 12   g  show a series of perspective views of manufacturing and filling of a container according a first embodiment of the present invention.  
     [0043]FIGS. 13 a - 13   f  show a series of perspective views of manufacturing and filling of a container according a second embodiment of the present invention.  
     [0044]FIG. 14 is a partial sectional view of a container according to the present invention.  
     [0045]FIG. 15 a  is a sectional view of a first embodiment of a connecting portion of a container of the present invention.  
     [0046]FIG. 15 b  is a side view of one end of the container of FIG. 15 a.    
     [0047]FIG. 16 a  is a sectional view of a second embodiment of a connecting portion of a container of the present invention.  
     [0048]FIG. 16 b  is a side view of one end of the container of FIG. 16 a.   
    
    
     DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS  
     [0049] A preferred embodiment of the present invention is now described with reference to the figures where like reference numbers indicate identical or functionally similar elements. While specific configurations and arrangements are discussed, it should be understood that this is done for illustrative purposes only. A person skilled in the relevant art will recognize that other configurations and arrangements can be used without departing from the spirit and scope of the invention.  
     [0050] The object of the present invention is to provide a container for a medicinal liquid, which is gas-tight and liquid-tight, and which has a filling volume that is suited to the intended purpose of use. The container plastically and irreversibly collapses under a slightly reduced pressure in a predetermined manner such that it can be substantially emptied.  
     [0051] The container of the present invention includes a foil bag which is closed at both ends. At a differential pressure between the interior of the container and its surroundings below 300 hPa (300 mbar), the foil bag is deformable by the external pressure and collapses. The container further includes a flange which is stable in respect of shape and which is sealingly mounted to the foil bag. The flange is a releasable connecting element for fitting the container on to a discharge connection member.  
     [0052] The foil bag is closed at at least one end with at least one welded seam which extends substantially transversely with respect to the axis of the bag. The flange has a sealing location which is stable in respect of shape. A discharge location for the liquid in the region of the flange is also provided, the discharge location being is stable in respect of shape.  
     [0053] In a further embodiment, the collapsible foil bag can be deformed by and collapsed due to an external pressure at a differential pressure of below 150 hPa (150 mbar) or preferably below 80 hPa (80 mbar).  
     [0054] The foil bag can be closed by a welded seam at both ends. In that case, the flange, which is stable in respect of shape, is sealingly welded to the side of the foil bag, preferably in the proximity of one end of the foil bag. The foil bag, however, may also be sealingly closed at one end by a welded seam and at the other end by the flange. In this case, the one end of the foil bag is welded to the flange, preferably on the periphery thereof.  
     [0055] The foil bag can be made of a tube which does not have a welded seam extending in the axial direction of the foil bag. In an alternate embodiment, the foil bag may have one or two welded seams extending in the longitudinal direction. The foil bag can be in the form of a flat bag or a bag with side folds. A bag with a welded seam extending in the longitudinal direction is preferred.  
     [0056] In one embodiment, the foil bag is made of a foil of metal or metal alloy, preferably aluminum, gold or copper, or plastic material, preferably a thermoplastic material. In another embodiment, the foil bag is made of a composite foil of plastic material and metal. The composite foil preferably comprises two or three foils which are joined together. The foil bag may further comprise a plastic foil to which a layer of metal, glass or ceramic is applied, for example by vapor deposition. The foils of plastic material or metal are several micrometers thick. The thickness of the vapor-deposition layers of metal, glass or ceramic is in the sub-micrometer range.  
     [0057] A composite foil consisting of two foils can be made of a metal foil and a plastic foil which are joined together. In this embodiment, the metal foil forms the inward side or the outward side of the composite foil. In another embodiment, the composite foil comprises two different plastic foils.  
     [0058] The composite foil comprising three foils preferably comprises two plastic foils, between which there is a foil comprising metal. All three foils are joined together. In place of the metal foil, the composite foil may have a layer of glass or ceramic, for example of silicon oxide (SiO x  ), which is produced by vapor deposition on a plastic foil.  
     [0059] In a further embodiment the inner foil of the composite foil comprises a copolymer, for example a polyethylene copolymer of ethylene-acrylic acid. The outer plastic foil of the composite foil is preferably a plastic material, for example polyethylene terephthalate, the melting temperature of which is higher than the melting temperature of the plastic material of the inner foil. That facilitates seam-wise welding of the plastic material of the inner foil, in the production of the foil bag.  
     [0060] In the composite foil, a bonding layer may possibly be provided between two foils.  
     [0061] The foil bag can comprise a plastic foil of a thickness of between 20 μm and 100 μm. It may also comprise a composite foil with an inner foil of plastic material of a thickness of between 20 μm and 100 μm and an outer foil of metal of a thickness of between 8 μm and 20 μm. It may also comprise a composite foil with an inner foil of plastic material of a thickness of between 20 μm and 100 μm, a central foil of metal of a thickness of between 8 μm and 20 μm and an outer foil of plastic material of a thickness of between 10 μm and 40 μm.  
     [0062] The container according to the invention is described in greater detail with reference to the Figures by way of example.  
     [0063] FIGS.  1  to  3  are perspective views of various embodiments of the foil bag which is closed at both ends. FIG. 1 shows a tubular bag  11  with a cylindrical flange  12  which is stable in respect of shape, and a U-shaped transverse seam  13  which closes the one end of the tubular bag and which at least partially extends in the longitudinal direction thereof. The edge  14  of the flange is connected to the other end of the tubular bag. Disposed on the axis of the flange is a hole  15  into which a discharge connection member can be introduced.  
     [0064]FIG. 2 shows a sealed-edge bag ( 21 ) which comprises two foils which are disposed one upon the other. It has two welded seams  22  extending in the longitudinal direction of the bag and, at its one end, a welded seam  23  extending in the transverse direction. The other end is connected to a flange  24  which is stable in respect of shape and which is of a fish-like form. Disposed at the center of the flange is a hole  25  into which a discharge connection member can be inserted.  
     [0065]FIG. 3 shows a side fold bag  31  with folds at both longitudinal sides, which is closed at each of its two ends by a respective transversely extending welded seam  32 . The flange  33  which is stable in respect of shape is welded on to the bag on a flat side thereof. A discharge connection member can be inserted into the hole  34  of the flange.  
     [0066] The flange which is stable in respect of shape can be of different shapes. If it is disposed at the end of the foil bag as the closure means thereof, it can be of a rotationally symmetrical form and can be adapted to the size of the end of the foil bag. The flange can also be provided with a guide passage into which the discharge connection member can be introduced. The discharge connection member is disposed within this guide passage when the container is fit thereon.  
     [0067] In one embodiment, the guide passage is provided with a press fit which embraces the discharge connection member. In one embodiment, the press fit is a portion of the guide passage which comprises a smooth inside wall of an inside diameter which only slightly differs from the outside diameter of the discharge connection member. In a further embodiment, a plurality of bulge portions can be provided in a portion of the guide passage on the inside wall thereof. The bulge portions can be for example three bulge portions which are of an elongate configuration and which are arranged symmetrically extending in the axial direction. It is further possible to provide a plurality of bulge portions which are arranged at an axial spacing from each other and which extend in the azimuthal direction and which for example form two rings or which comprise a plurality of ring portions. Furthermore, the bulge portions can extend in a helical configuration, such that they can comprise a plurality of helix portions distributed on the inside wall of the guide passage or a helix portion whose length is greater than the periphery of the guide passage. A press fit of that kind permits the container to be fitted on to the discharge connection member and can provide for a sufficiently firm fit of the flange on the discharge connection member. Furthermore, after it has been emptied, the container can be withdrawn from the discharge connection member without damaging the latter.  
     [0068] The flange can be in one or more parts. A multi-part flange is preferably a two-part flange. An outwardly disposed part of the flange is sealingly connected to the foil bag. The outer part contains an opening which is sealingly closed with the inner part. The two parts can be screwed together by means of a screwthread or can be connected together by means of a snap-action connection or by ultrasonic welding. A one-part flange is of a similar configuration to the two-part flange, but it does not include any connecting elements. The flange can be produced at the same time with a press fit, a groove for the sealing location, and a pierceable membrane.  
     [0069] The flange can be made of rubber, metal or plastic material, preferably a thermoplastic material. It may be desirable to produce the flange from the same plastic material as that used to form the foil bag or the inward side of the foil bag. A flange which is made of rubber or metal can be connected to the foil bag by gluing or possibly by vulcanization.  
     [0070] FIGS.  4  to  7  are sectional views of various embodiments of the flange. FIG. 4 is a view in longitudinal section through a one-piece flange  41  having a cylindrical guide passage  42 , which is in the form of a press fit, for a cylindrical discharge connection member. The outer end of the guide passage is beveled while the other end is closed by a membrane  43  which is disposed at an incline to the axis of the flange. Flange  41  is produced in one working operation. The edge of flange  41  is connected to a foil bag  44 .  
     [0071]FIG. 5 a  shows a longitudinal section through a multi-part cylindrical flange, and FIG. 5 b  shows a cross-section taken along a line  5 - 5  of FIG. 5 a . A lower part  51  of the flange is connected to a foil bag  53 . An upper part  52  of the flange fits in an opening in lower part  51 . Upper part  52  is provided with a guide passage  54  in which there are three elongate ridges  55 , as shown in FIG. 5 b , extending in the axial direction of the flange. The elongate ridges  55  act as a press fit for a discharge connection member. An annular ridge  56  acts as a seal. Lower part  51  and upper part  52  are welded together at their contact surface  57 . Guide passage  54  has an entry opening with an inclined insertion surface. This entry opening is sealed off by a sealing foil  58 .  
     [0072]FIG. 6 shows a multi-part cylindrical flange which is stable in respect of shape. A lower part  61  of the flange is connected to a foil bag  63 . An upper part  62  of the flange projects into the annular lower part  61 . Disposed in upper part  62  as a seal is an  0 -ring  64  which is held in place by a gland  65  that is pressed into position. The opening in gland  65  serves as a guide passage for a discharge connection member. A peripherally extending ridge  66  is disposed on the inside of the seal on upper part  62 , which provides a press fit. A discharge connection member  67  is inserted into the guide passage of gland  65 . The container is held on discharge connection member  67  by means of peripherally extending ridge press fit  66 . Lower part  61  and upper part  62  are welded together at their contact surface  68 .  
     [0073]FIG. 7 shows another embodiment of a multi-part flange of the present invention. A lower part  71  of the flange is connected to a foil bag  73 . An upper part  72  of the flange is disposed in the annular lower part  71  which is provided with a shoulder. Upper part  72  includes a flat ring  74  as a seal, which is held in place by a gland  75  which is pressed into position. A guide passage  76  for a discharge connection member is disposed beneath flat ring  74 . A press fit is formed by two ridges  77  within guide passage  76 , extending therearound in a screwthread-like configuration. A membrane  78  is provided in the proximity of the lower end of guide passage  76  and perpendicular to the axis of the flange. Membrane  78  is pierced when the container is fit onto the discharge connection member. Membrane  78  is produced with upper part  72  in one working operation. Lower part  71  and upper part  72  are connected together at their contact surface  79 .  
     [0074]FIG. 8 a  is a view in cross-section of a one-part flange  81  which is stable in respect of shape and which is disposed on the side of a foil bag  82 . Flange  81  has a guide passage  83  which serves as a press fit for a discharge connection member. Flange  81  is sealed on its outward side by a sealing foil  84 . When the container is fitted on to a discharge connection member  85 , having a beveled end, the foil bag is pierced at an inner end  86  of guide passage  83 .  
     [0075]FIG. 8 b  shows an exploded view in cross-section through a commercially available laminate foil having three layers making up the foil bag. An inner foil  87  comprises polyethylene (40 μm in thickness), a central foil  88  acts as the diffusion barrier of aluminum (12 μm in thickness) and an outer foil  89  comprises polyethylene terephthalate (12 μm in thickness).  
     [0076] The welded seam at one or both ends of the foil bag can be of a U-, V- or T-shaped configuration. The seam extends substantially transversely with respect to the axis of the bag. In one embodiment, the welded seam extends partially in the direction of the axis of the bag, whereby the defined deformation of the foil bag is promoted when liquid is drawn therefrom.  
     [0077] A sealing location or sealing means can be provided within or at one of the ends of the guide passage. The sealing location can comprise a ring which is disposed in a groove provided on the inside wall of the guide passage. The ring can be of an O-shaped or substantially rectangular cross-section. The ring may be provided with a sealing lip. The ring is made of an elastomer, a thermoplastic elastomer or rubber. The sealing location closes the filling space or chamber of the container which is fitted on to the discharge connection member gas-tightly and liquid-tightly in relation to the ambient air. Further, the sealing location permits the emptied container to be withdrawn from the discharge connection member. The sealing location is required if the sealing effect of the press fit is not sufficient.  
     [0078] The welded seams on the foil bag can be from 0.7 mm to 3 mm wide. The width of the welded seams is selected in accordance with the requirements for sealing integrity and durability of the seam. Wide, longitudinal seams on the foil bag can be bent over after the welding operation so that they are disposed on the outside against the foil bag and so that the foil bag is only a little wider than its width in the unwelded part between the welded seams.  
     [0079] The welded seams on the foil bag and the weld location between the foil bag and the flange are produced using known processes such as thermal welding, ultrasonic welding or induction welding in the case of composite foils with a metal layer, wherein the weld locations are preferably pressed together in the heated condition. Such processes are set forth for example in EP-0 111 131 and EP-0 130 239, the disclosures of which are incorporated herein by reference in their entireties.  
     [0080]FIGS. 9 a ,  9   b ,  10   a  and  10   b  show cross-section and side views of various embodiments of the welded seam with which the foil bag is closed at at least one end. FIGS. 11 a  and  11   b  show a side view and plan view of an alternate embodiment of the welded seam on the end of the bag.  
     [0081]FIG. 9 a  shows a U-shaped welded seam  91  which extends partially in the longitudinal direction of a foil bag  92 . On one side of foil bag  92 , welded seam  91  merges with a welded seam  93  of the foil bag, with the welded seam  93  extending in the longitudinal direction. FIG. 9 b  is a view in cross-section through the foil bag taken along a line  9 - 9  of FIG. 9 a . The inner layer of the folded multi-layer foil  94  is welded in welded seams  91  and  93 .  
     [0082]FIG. 10 a  shows a V-shaped welded seam  101  which extends partially in the longitudinal direction of a foil bag  102 . In this case foil bag  102  comprises a tubular foil without a longitudinal seam. FIG. 10 b  shows a view in cross-section through the foil bag taken along a line  10 - 10  of FIG. 10 a . The folded single-layer foil  103  is welded in welded seam  101 .  
     [0083]FIG. 11 a  shows a T-shaped welded seam  111  as a side view, and FIG. 11 b  is a plan view of the welded end of a foil bag  112 . The three limbs of the T-shaped seam  111  are overall as long as the foil bag is wide, when the foil bag  112  is collapsed flat, outside the T-shaped seam.  
     [0084] A foil bag which is welded with a U-, V- or T-shaped seam is no greater in the region of the transverse seam than the diameter of the casing into which the foil bag is possibly inserted.  
     [0085] The discharge location is preferably in the form of a puncture or perforation location. A pierceable membrane can be provided at the puncture or perforation location, the membrane being pierced when the container is fitted on to the discharge connection member. The membrane is preferably arranged between the sealing location and the liquid chamber or space in the foil bag. The pierceable membrane can be disposed at one of the ends or within the guide passage. It is preferably disposed directly at the end of the guide passage or in the proximity of that end which is towards the liquid space. It can be a part of the flange or a part of the foil bag. If it is a part of the flange, it can be produced at the same time as the flange, and can be made of the same plastic material as the flange. The pierceable membrane acts as an original closure means for the filling space or chamber in the foil bag.  
     [0086] In a further embodiment the discharge location can be sealed with a sealing foil which is pulled off before the container is fitted on to the discharge connection member or which is pierced when the container is fitted on to the discharge connection member.  
     [0087] The container may be disposed in a casing which is stable in respect of shape, and which is made of metal or plastic material. One end of the casing is releasably or non-releasably connected to the flange, while the other end of the casing may be closed with a bottom. In one embodiment, the casing is substantially closed all around, however, it includes at least one opening. Alternatively, a gap may be provided at the location of connection of the casing to the flange. The casing can also be in the form of a basket which is stable in respect of shape and which has many openings. In an alternate embodiment, instead of the casing, the container may be disposed in a U-shaped holder which is stable in respect of shape, wherein the end of each limb of the U-shaped holder is secured to the flange, and the limbs are longer than the foil bag.  
     [0088] In a preferred embodiment, the container disposed in a casing is connected to the casing only at the flange. The end which is closed with a welded seam or the two ends of the foil bag, which are closed with a welded seam, are not connected to the casing.  
     [0089] Upon the transfer of liquid out of the container into the discharge connection member the foil bag collapses flat due to the action of the external pressure. Air passes through the opening in the casing or through the gap between the casing and the flange, into the space between the casing and the foil bag, and provides for pressure equalization. As such, no valve is required in the foil bag and the liquid in the foil bag does not come into contact with air.  
     [0090] Manufacture and filling of the container according to the invention is diagrammatically illustrated in perspective views in FIGS. 12 a - 12   g  and  13   a - 13   f.    
     [0091] As shown in FIG. 12 a , a folded foil strip is provided at the cut sides with a welded seam in the longitudinal direction, divided into portions and shaped to form a tube. The lower part of a two-part cylindrical flange, which is produced by an injection molding process, is welded to one end of the tub, as shown in FIG. 12 b . The other end of the tube is welded with a U-shaped transverse seam as shown in FIG. 12 c . The finished container is pushed into a cylindrical casing of aluminum, as shown in FIG. 12 d , the edge of which is pressed into a groove or channel in the edge of the cylindrical flange. The container is fixedly joined to the casing in that way. The empty container which is disposed in the casing is then filled with a fluid through the lower part of the flange, which is provided with an opening, as shown in FIG. 12 e . After the filling operation the upper part of the flange is pressed into the lower part, as shown in FIG. 12 f , and the two parts are sealingly joined together. The finished part, as shown in FIG. 12 g , is ready for being fit onto a discharge connection member.  
     [0092] An alternate production process is illustrated in FIGS. 13 a - 13   f . A portion of a foil tube is provided with a longitudinal seam, as shown in FIG. 13 a . The tube is connected at one end to a one-piece flange which is closed by a sealing foil, as shown in FIG. 13 b . The container is filled with a fluid through the other open end of the foil tube, as shown in FIG. 13 c . The open end of the foil tube is closed by a U-shaped transverse seam, as shown in FIG. 13 d . The filled container is fit into a casing of plastic material, as shown in FIG. 13 e . The edge of the plastic casing is snap-fit onto the edge of the one-piece flange. The finished part, as shown in FIG. 13 f , is ready for being fit onto a discharge connection member.  
     [0093]FIG. 14 is a partly cross-sectional view of a typical container  141  according to the present invention which is filled with a fluid and which is disposed in a metal casing  142 . At one end, a foil bag is welded by a U-shaped seam  143 . At its other end, the foil bag is welded to an edge  144  of a lower part  145  of a two-part cylindrical flange which is stable in respect of shape. Metal casing  142  has a bottom  146  in which there is a hole formed therein, through which air can pass into the space between metal casing  142  and the foil bag. The open end of metal casing  142  is pressed into a groove or channel  147  in the edge of lower part  145  of the flange. Metal casing  142  is fixedly connected to the flange. An upper part  148  of the flange is fit into an opening in lower part  145 . Lower part  145  and upper part  148  are connected by a snap-action closure  149  and provided with a flat seal  150 . A guide passage  151  is closed at its inner end by a membrane  152  and sealed at its outer end by a sealing foil  153 .  
     [0094] The metal casing shown in FIG. 14 is preferably made of aluminum. In one embodiment, it is 43 mm in length and has an outside diameter of 17 mm and a wall which is 0.5 mm in thickness. The two-piece flange is preferably made of polyethylene and is produced by an injection molding process. The upper part of the flange including the membrane is preferably produced in one step in the process. The guide passage in the upper part of the flange preferably has an inside diameter of 2.5 mm at the location of the press fit and fits firmly onto a discharge connection member.  
     [0095] The foil bag is diffusion-tight with respect to the medicinal liquid and its constituents and with respect to gases. The material for the foil bag and possibly the structure of the composite foil are suitably selected for use with the liquid. Diffusion-tight in accordance with the present invention denotes a loss of liquid (measured with ethanol at ambient temperature) of the container due to diffusion of less than 0.6 mg per day, preferably less than 0.4 mg per day, particularly preferably less than 0.2 mg per day, in particular less than 0.1 mg per day.  
     [0096] The inner foil or the inward side of the foil bag is in contact with the liquid introduced into the bag. The material adopted for that foil is a material which is not attacked by the liquid and which does not adversely affect the liquid. That foil is preferably in the form of a weldable foil.  
     [0097] One of the foils or a layer which is applied for example by vapor deposition is the diffusion barrier. This barrier prevents diffusion of the liquid or the constituents thereof and prevents the diffusion of gases from or into the foil bag. It may be desirable to protect the diffusion barrier from mechanical damage and from tearing when the foil is bent. One method of protection is to apply a further plastic foil to the diffusion barrier so that the diffusion of liquid or gases remains durably prevented.  
     [0098] As the foil bag is diffusion-tight in relation to gases, the reduced pressure which occurs in the foil bag due to the discharge of liquid therefrom cannot be compensated by gas diffusing therein. As such, the foil bag reliably collapses even when liquid is very slowly discharged from the container. The liquid can also be drawn from the foil bag in a large number of partial quantities, for example 200 metered amounts, distributed over a prolonged period of time, for example three months.  
     [0099] The container, which is disposed in a substantially closed casing, is inaccessible from the exterior and cannot be damaged when stored or when it is fit onto the discharge connection member. The substantially closed casing, the casing which is provided in the form of a basket with many openings, or the holder which is stable in respect of shape facilitates storage of the container with the thin-gauge foil bag. These casings also facilitate handling thereof when it is fit onto the discharge connection member and when the empty container is withdrawn from the discharge connection member.  
     [0100] One example of a discharge connection member is the hollow plunger of an atomizer for medicinal liquids. An atomizer of that kind is described in DE-195 36 902.5 and in WO-97/12687, the disclosures of which are incorporated herein by reference in their entireties. An exemplary atomizer is shown in FIGS. 6 a  and  6   b  of these disclosures. The hollow plunger of the atomizer is in the form of a discharge connection member for the medicinal liquid contained in the container according to the invention. The container is fit onto the hollow plunger which is preferably disposed on the axis of the atomizer. In such a configuration, the end of the hollow plunger sticks into the discharge location and thus dips into the medicinal liquid. The sealing location in the flange sealingly closes off the interior of the container relative to the outside wall of the hollow plunger. The press fit holds the container sufficiently mechanically fast on the hollow plunger.  
     [0101] It may be desirable instead of or in addition to the press fit (force-locking connection) between the container and the discharge connection member to provide a releasable, positively locking connection between the flange which is stable in respect of shape of the container and the discharge device, for example an atomizer. A connection of that kind can be in the form of a push-in snap connection comprising a plurality of snap hooks which are mounted in a connecting portion in the discharge device. When the container is fit onto the discharge device the snap hooks engage into an opening in the flange, for example into a peripherally extending groove or behind an edge of the flange. The snap noses are preferably of a round shape or are beveled in both directions of movement of the container so that an empty container can be removed with the application of a moderate amount of force and a full container can be fit onto the discharge device with a moderate amount of force.  
     [0102]FIGS. 15 a  and  15   b  show a releasable, positively locking, push-in snap connection between the flange which is stable in respect of shape of the container and the connecting portion in a discharge device.  
     [0103]FIG. 15 a  is a view in cross-section through a connecting portion  154  which is disposed in the discharge device and which on its axis includes discharge connection member  67 . Discharge connection member  67  is surrounded by a plurality of snap hooks  155  with snap noses  156  of round cross-section. Snap hooks  155  are separated from each other by intermediate spaces and may involve an azimuthal width of 10 degrees to 60 degrees. A portion  157  which does not include any snap nose can be provided between two snap hooks  155 . Portion  157  bears in positively locking relationship against the outside wall of the inserted container.  
     [0104]FIG. 15 b  is a side view of the end of a container which is disposed in a casing  142  and whose flange  148 , which is stable in respect of shape, projects out of casing  142 . As shown in FIG. 14, casing  142  has a peripherally extending groove  158 , preferably in the region of the flange part projecting into casing  142 . Snap noses  156  of the container when fitted into the connecting portion  154  engage into groove  158 , whereby the container is releasably and positively lockingly connected to connecting portion  154 .  
     [0105]FIGS. 16 a  and  16   b  show a further embodiment of a releasable, positively locking, push-in snap connection.  
     [0106]FIG. 16 a  is a view in cross-section through a connecting portion  161  which is disposed in the discharge device and which on its axis includes discharge connection member  67 . Discharge connection member  67  is surrounded by a plurality of tongue-shaped snap hooks  162  with snap noses  163  whose flanks are beveled in both directions of movement of the container. Snap hooks  162  are disposed at an azimuthal spacing from each other.  
     [0107]FIG. 16 b  is a side view of the end of a container which is disposed in a casing  142  and whose flange  148 , which is stable in respect of shape, projects out of casing  142 . When the container is fitted into connecting portion  154 , snap noses  163  engage into peripherally extending groove  147  of the part, which projects out of the casing, of the flange  148 , whereby the container is releasably connected to the connecting portion in positively locking relationship.  
     [0108] The container according to the invention is particularly suitable as an interchangeable cartridge for inhalable medicament solutions in propellant-free atomizers. The filling volume of the container can be from 0.5 ml to 5 ml, preferably from 1 ml to 4 ml and particularly preferably from 1 ml to 3 ml or from 2 ml to 4 ml. Those solutions are discharged in a portion-wise manner with a respective dosage of 10 μl to 50 μl, preferably from 15 μl to 20 μl.  
     [0109] The casing diameter can be from 10 mm to 30 mm, preferably from 12 mm to 17 mm. The length of the container including the part, which projects out of the casing, of the flange which is stable in respect of shape can be from 20 mm to 60 mm, preferably from 30 mm to 50 mm.  
     [0110] The container according to the invention serves as a primary packaging means for accommodating a medicinal liquid which for example contains a medicament dissolved in a solvent. Suitable solvents are for example water, ethanol or mixtures thereof. The medicaments used are for example Berotec (fenoterol-hydrobromide; 1-(3,5-dihydroxyphenyl)-2-[[1-(4-hydroxybenzyl)-ethyl]-amino]-ethanol-hydrobromide), Atrovent (ipratropium bromide), Berodual (combination of fenoterol-hydrobromide and ipratropium-bromide), Salbutamol (or Albuterol), Combivent, Oxivent (oxitropium bromide), Ba 679 (tiotropium bromide), BEA 2108 (di-(2-thienyl)-glycol acid tropenol ester), Flunisolid, Budesonid, Beclomethason and others.  
     [0111] WO-98/27959 describes stabilized aqueous medicament preparations for the production of propellant-free aerosols for inhalation, the disclosure of which is incorporated herein by reference in its entirety. In particular, reference is directed to the formulations claimed therein and set forth in the examples.  
     [0112] Suitable medicament preparations in ethanol solution are set forth for example in WO-97/01329, the disclosure of which is incorporated herein by reference in its entirety. In particular, reference is directed to the active substances specified therein (see therein pages 2 and 3) and the stabilized formulations claimed therein.