Patent Publication Number: US-2021186567-A1

Title: Spinal correction system and method

Description:
TECHNICAL FIELD 
     The present disclosure generally relates to medical devices for the treatment of spinal disorders, and more particularly to a surgical system and a method for correction of a spinal disorder. 
     BACKGROUND 
     Spinal disorders such as degenerative disc disease, disc herniation, osteoporosis, spondylolisthesis, stenosis, scoliosis and other curvature abnormalities, kyphosis, tumor, and fracture may result from factors including trauma, disease and degenerative conditions caused by injury and aging. Spinal disorders typically result in symptoms including pain, nerve damage, and partial or complete loss of mobility. 
     Non-surgical treatments, such as medication, rehabilitation and exercise can be effective, however, may fail to relieve the symptoms associated with these disorders. Surgical treatment of these spinal disorders includes correction, corpectomy, discectomy, laminectomy, fusion, fixation and implantable prosthetics. Correction treatments used for positioning and alignment of vertebrae may employ implants, such as, for example, spinal constructs and interbody devices, for stabilization of a treated section of a spine. In some cases, the spinal constructs may be manipulated with surgical instruments for compression and distraction of vertebrae. This disclosure describes an improvement over these prior technologies. 
     SUMMARY 
     In one embodiment, a spinal construct is provided. The spinal construct comprises a first member engageable with a receiver of a first fastener having a shaft fixed with tissue. A second member is engageable with a receiver of a second fastener having a shaft fixed with the tissue. A longitudinal element connects the members. At least one of the members includes a mating element that is releasably engageable with a surgical instrument to manipulate the tissue such that movement of the receivers relative to the shafts is resisted and/or prevented. In some embodiments, surgical instruments, implants, systems and methods are disclosed. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       The present disclosure will become more readily apparent from the specific description accompanied by the following drawings, in which: 
         FIG. 1  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 2  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 3  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 4  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 5  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 6  is a cutaway view of components of the system shown in  FIG. 5 ; 
         FIG. 7  is a perspective view in part cross section of the components shown in  FIG. 6 ; 
         FIG. 8  is a break away perspective view of the components shown in  FIG. 6 ; 
         FIG. 9  is a side view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 10  is a cross section view of the components shown in  FIG. 9 ; 
         FIG. 11  is a side view of the components shown in  FIG. 9 ; 
         FIG. 12  is a cross section view of the components shown in  FIG. 9 ; 
         FIG. 13  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 14  is a lateral view of vertebrae; 
         FIG. 15  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; 
         FIG. 16  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; 
         FIG. 17  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; 
         FIG. 18  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; 
         FIG. 19  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; 
         FIG. 20  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; 
         FIG. 21  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; 
         FIG. 22  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 23  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 24  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 25  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 26  is a perspective view in part cutaway of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 27  is a perspective view in part cutaway of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 28  is a perspective view in part cutaway of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 29  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; 
         FIG. 30  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; and 
         FIG. 31  is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae. 
     
    
    
     DETAILED DESCRIPTION 
     The exemplary embodiments of the system and related methods of use disclosed are discussed in terms of medical devices for the treatment of musculoskeletal disorders and more particularly, in terms of a surgical system and method for correction of a spine disorder. In some embodiments, the present surgical system comprises a spinal construct that can be employed with one or more surgical instruments for a pedicle subtraction osteotomy (PSO). In some embodiments, the present surgical system can be employed with a posterior vertebral column resection to correct angular and fixed kyphotic deformity, such as post traumatic deformity, congenital deformity and/or post infectious deformity. 
     In some embodiments, the present surgical system comprises a spinal construct that can be employed with one or more surgical instruments for three column manipulation of vertebrae. In some embodiments, the present surgical system comprises a spinal construct that can be employed with one or more surgical instruments for compressing, distracting or otherwise manipulating the spine. In some embodiments, the spinal construct is configured to spread an applied load to multiple bone screws to avoid pedicle screw plow and/or bone fracture. In some embodiments, the spinal construct comprises a connector that quickly and effectively bridges two screws in-situ while maintaining a low profile for improved visualization. 
     In some embodiments, the present surgical system includes connectors that lock onto bone screws and a rod by engaging a surgical inserter instrument into a rod slot of the bone screws. In some embodiments, the present surgical system is employed with a method that facilitates applying the connectors to the bone screws. In some embodiments, the surgical instruments can be quickly clicked on and off of the connectors. In some embodiments, the present surgical system is configured to provide surgeons with an efficient way to share load between bone screws and reduce the occurrence of screw plow and the resulting risk of bone fracture, screw toggle and screw pull out. 
     In some embodiments, the present surgical system is employed with a method that includes the steps of inserting bone screws in two vertebrae above and two vertebrae below a PSO site. In some embodiments, the present surgical system can include multi-axial screws (MAS) and/or dual rod multi-axial screws (DRMAS). In some embodiments, the method includes the step of attaching a rod instrument with an integrated set screw to a bone screw. The set screw attaches the rod instrument proximal to the PSO. In some embodiments, the method includes the step of securing an instrument with an integrated set screw to a distal end of the rod instrument. In some embodiments, the method includes the step of attaching a rack distractor/compressor with numerous motion points to the spinal construct. In some embodiments, the method includes the step of locking all motion points to secure the spine. In some embodiments, the present surgical system can include various instruments. In some embodiments, an angle indicating osteotome can be used to guide a cut angle of selected vertebrae. In some embodiments, the method includes the step of placing an intrabody implant in the PSO to preserve anterior height, maintain alignment of the two sides of the PSO and act as a fulcrum for closure. In some embodiments, the method includes the step of setting the rack to compression and unlocking one of the motion points to allow the spine to pivot at the PSO during closure. 
     In some embodiments, the present surgical system comprises a spinal construct that includes a connector body, a connector collar, a connector shaft, connector legs, connector feet and a rod. In some embodiments, the present surgical system comprises a surgical instrument that includes a driver, a sleeve and a spring latch. In some embodiments, the surgical instrument comprises an inserter that includes a sleeve and a driver assembly that slides over the spinal construct. In some embodiments, the surgical instrument comprises spring loaded latches that retain the connector body in the sleeve. In some embodiments, the inserter sleeve fits into a rod slot of a bone screw to orient a head of the bone screw. 
     In some embodiments, the present surgical system is employed with a method of attaching the surgical instrument with the spinal construct including the steps of pushing the driver toward the bone screw such that it translates through the sleeve and drives the connector collar down the legs. In some embodiments, a change in the connector leg profile causes the legs to close when the collar is down, and open when the collar is in an up position. In some embodiments, the connector is spring loaded to an open position such that the legs close and engage slots on the sides of the screw head. As such, the collar can translate down the legs and engage the rod to bind the rod between the sleeve and the connector feet. In some embodiments, the driver is rotated to thread the connector shaft into the connector body. This configuration locks the legs and the rod. 
     In some embodiments, the spring latches are engaged to remove the inserter from the spinal construct. In some embodiments, this engagement binds the screw heads in 5 of 6 degrees of freedom such that the screw heads are free to roll in a medial lateral direction. In some embodiments, surgical instruments can now click onto the spinal construct using the sleeve and spring latch quick connect engagement. In some embodiments, a distractor/compressor connects two spinal constructs to stabilize and manipulate the spine during a PSO procedure. 
     In some embodiments, the present surgical system includes a surgical instrument that can compress or distract and restore curvature of a spine. In some embodiments, the present surgical system includes instruments and tools for correcting a sagittal deformity and rebalancing a spine of a body. In some embodiments, the present surgical system is employed to treat degenerative deformities of a spine in a sagittal plane, for example, ankylosing spondylitis. In some embodiments, the present surgical system is employed to treat hyper-kyphosis, flat lumbar back and cervical hyper lordosis, including disorders that create an unbalance of a body and loss of alignment between body parts. In some embodiments, the present surgical system provides a selected amount of correction to apply a selected balance to a spine and provides control and adjustment to the amount of correction. In some embodiments, the present surgical system includes a series of tools and instruments that allow formulation of a type of correction applied and can control the correction stabilization using posterior instrumentation. 
     In some embodiments, one or all of the components of the surgical system are disposable, peel-pack, pre-packed sterile devices used with an implant. One or all of the components of the surgical system may be reusable. The surgical system may be configured as a kit with multiple sized and configured components. 
     In some embodiments, the present disclosure may be employed to treat spinal disorders such as, for example, degenerative disc disease, disc herniation, osteoporosis, spondylolisthesis, stenosis, scoliosis and other curvature abnormalities, kyphosis, tumor and fractures. In some embodiments, the present disclosure may be employed with other osteal and bone related applications, including those associated with diagnostics and therapeutics. In some embodiments, the disclosed surgical system and methods may be alternatively employed in a surgical treatment with a patient in a prone or supine position, and/or employ various surgical approaches to the spine, including anterior, posterior, posterior mid-line, lateral, postero-lateral, and/or antero-lateral approaches, and in other body regions. The present disclosure may also be alternatively employed with procedures for treating the lumbar, cervical, thoracic, sacral and pelvic regions of a spinal column. The system and methods of the present disclosure may also be used on animals, bone models and other non-living substrates, such as, for example, in training, testing and demonstration. 
     The present disclosure may be understood more readily by reference to the following detailed description of the embodiments taken in connection with the accompanying drawing figures, which form a part of this disclosure. It is to be understood that this application is not limited to the specific devices, methods, conditions or parameters described and/or shown herein, and that the terminology used herein is for the purpose of describing particular embodiments by way of example only and is not intended to be limiting. In some embodiments, as used in the specification and including the appended claims, the singular forms “a,” “an” and “the” include the plural, and reference to a particular numerical value includes at least that particular value, unless the context clearly dictates otherwise. Ranges may be expressed herein as from “about” or “approximately” one particular value and/or to “about” or “approximately” another particular value. When such a range is expressed, another embodiment includes from the one particular value and/or to the other particular value. Similarly, when values are expressed as approximations, by use of the antecedent “about,” it will be understood that the particular value forms another embodiment. It is also understood that all spatial references, such as, for example, horizontal, vertical, top, upper, lower, bottom, left and right, are for illustrative purposes only and can be varied within the scope of the disclosure. For example, the references “upper” and “lower” are relative and used only in the context to the other, and are not necessarily “superior” and “inferior”. 
     As used in the specification and including the appended claims, “treating” or “treatment” of a disease or condition refers to performing a procedure that may include administering one or more drugs to a patient (human, normal or otherwise or other mammal), employing implantable devices, and/or employing instruments that treat the disease, such as, for example, microdiscectomy instruments used to remove portions bulging or herniated discs and/or bone spurs, in an effort to alleviate signs or symptoms of the disease or condition. Alleviation can occur prior to signs or symptoms of the disease or condition appearing, as well as after their appearance. Thus, treating or treatment includes preventing or prevention of disease or undesirable condition (e.g., preventing the disease from occurring in a patient, who may be predisposed to the disease but has not yet been diagnosed as having it). In addition, treating or treatment does not require complete alleviation of signs or symptoms, does not require a cure, and specifically includes procedures that have only a marginal effect on the patient. Treatment can include inhibiting the disease, e.g., arresting its development, or relieving the disease, e.g., causing regression of the disease. For example, treatment can include reducing acute or chronic inflammation; alleviating pain and mitigating and inducing re-growth of new ligament, bone and other tissues; as an adjunct in surgery; and/or any repair procedure. Also, as used in the specification and including the appended claims, the term “tissue” includes soft tissue, ligaments, tendons, cartilage and/or bone unless specifically referred to otherwise. 
     The following discussion includes a description of a surgical system and related methods of employing the surgical system in accordance with the principles of the present disclosure. Alternate embodiments are also disclosed. Reference is made to the exemplary embodiments of the present disclosure, which are illustrated in the accompanying figures. Turning to  FIGS. 1 and 2 , there are illustrated components of a surgical system, such as, for example, a spinal correction system  10 . 
     The components of spinal correction system  10  can be fabricated from biologically acceptable materials suitable for medical applications, including metals, synthetic polymers, ceramics and bone material and/or their composites. For example, the components of spinal correction system  10 , individually or collectively, can be fabricated from materials such as stainless steel alloys, commercially pure titanium, titanium alloys, Grade 5 titanium, super-elastic titanium alloys, cobalt-chrome alloys, superelastic metallic alloys (e.g., Nitinol, super elasto-plastic metals), ceramics and composites thereof such as calcium phosphate (e.g., SKELITE™), thermoplastics such as polyaryletherketone (PAEK) including polyetheretherketone (PEEK), polyetherketoneketone (PEKK) and polyetherketone (PEK), carbon-PEEK composites, PEEK-BaSO 4  polymeric rubbers, polyethylene terephthalate (PET), fabric, silicone, polyurethane, silicone-polyurethane copolymers, polymeric rubbers, polyolefin rubbers, hydrogels, semi-rigid and rigid materials, elastomers, rubbers, thermoplastic elastomers, thermoset elastomers, elastomeric composites, rigid polymers including polyphenylene, polyimide, polyimide, polyetherimide, polyethylene, epoxy, bone material including autograft, allograft, xenograft or transgenic cortical and/or corticocancellous bone, and tissue growth or differentiation factors, partially resorbable materials, such as, for example, composites of metals and calcium-based ceramics, composites of PEEK and calcium based ceramics, composites of PEEK with resorbable polymers, totally resorbable materials, such as, for example, calcium based ceramics such as calcium phosphate, tri-calcium phosphate (TCP), hydroxyapatite (HA)-TCP, calcium sulfate, or other resorbable polymers such as polyaetide, polyglycolide, polytyrosine carbonate, polycaroplaetohe and their combinations. 
     Various components of spinal correction system  10  may have material composites, including the above materials, to achieve various desired characteristics such as strength, rigidity, elasticity, compliance, biomechanical performance, durability and radiolucency or imaging preference. The components of spinal correction system  10 , individually or collectively, may also be fabricated from a heterogeneous material such as a combination of two or more of the above-described materials. The components of spinal correction system  10  may be monolithically formed, integrally connected or include fastening elements and/or instruments, as described herein. 
     Spinal correction system  10  is employed, for example, with a minimally invasive procedure, including percutaneous techniques, mini-open and open surgical techniques to deliver and introduce instrumentation and/or components of spinal constructs at a surgical site within a body of a patient, for example, a section of a spine. In some embodiments, one or more of the components of spinal correction system  10  are configured for engagement with spinal constructs attached with vertebrae to manipulate tissue and/or correct a spinal disorder, such as, for example, a sagittal deformity, as described herein. In some embodiments, spinal correction system  10  may be employed with surgical procedures, such as, for example, corpectomy, discectomy and/or fracture/trauma treatment and may include fusion and/or fixation that employ implants to restore the mechanical support function of vertebrae. 
     Spinal correction system  10  includes a spinal construct, such as, for example, a connector  12 . Connector  12  is engageable with bone fasteners and a surgical instrument to manipulate tissue, as described herein. Connector  12  includes a member  16  and a member  116 . Member  16  includes a body, such as, for example, a support  18 . Support  18  includes a wall  20  that extends between an end  22  and an end  24 . Wall  20  includes a surface  26  and a surface  28  that extend between ends  22 ,  24 . Wall  20  extends parallel to an axis X 1  defined by a longitudinal element, such as, for example, a rod  36 , as described herein. In some embodiments, wall  20  may extend in alternate configurations, for example, arcuate, offset, staggered and/or angled portions. 
     Wall  20  includes an extension, such as, for example, a leg  30 . Leg  30  extends from end  22 . Leg  30  is oriented substantially perpendicular to axis X 1 . In some embodiments, leg  30  may be variously oriented relative to axis X 1 , such as, for example, transverse and/or angled. Leg  30  includes a tapered configuration to facilitate engagement with a receiver of a fastener, as described herein. 
     Leg  30  includes a surface  32  that defines a recess  34 . Recess  34  is arcuate to facilitate engagement with rod  36 . In some embodiments, leg  30  is monolithically formed with rod  36 . In some embodiments, leg  30  is attached with rod  36  via clips, hooks, adhesives and/or flanges. In some embodiments, surface  32  is smooth or even. In some embodiments, surface  32  may be rough, textured, porous, semi-porous, dimpled and/or polished. 
     Wall  20  includes an extension, such as, for example, a leg  40  disposed in spaced apart relation to leg  30 . Leg  40  extends from end  24 . Leg  40  is oriented substantially perpendicular to axis X 1 . In some embodiments, leg  40  may be variously oriented relative to axis X 1 , such as, for example, transverse and/or angled. Leg  40  includes a tapered configuration configured to facilitate engagement with a receiver of a fastener, as described herein. 
     Leg  40  includes a surface  42  that defines a recess  44 . Recess  44  is arcuate to facilitate engagement with rod  36 . In some embodiments, leg  40  is monolithically formed with rod  36 . In some embodiments, leg  40  is attached with rod  36  via clips, hooks, adhesives and/or flanges. In some embodiments, surface  42  is smooth or even. In some embodiments, surface  42  may be rough, textured, porous, semi-porous, dimpled and/or polished. 
     Rod  36  extends between an end  50  and an end  52  defining axis X 1 , as described herein. Rod  36  includes a surface  54  configured for engagement with a coupling member of support  116 , as described herein. In some embodiments, rod  36  is configured to connect the receiver of one fastener with the receiver of an adjacent fastener to connect members  16 ,  116 , as described herein. 
     Wall  20  includes an inner surface  62  that defines a cavity  64  extending between surfaces  26 ,  28 . Cavity  64  is configured for disposal of a coupling member, such as, for example, a set screw  80 . In some embodiments, set screw  80  is integrally connected with member  16 . Set screw  80  is configured to fix support  16  and rod  36  with the receiver of a bone fastener, as described herein. 
     Connector  12  includes a member  116 . Member  116  includes a body, such as, for example, a support  118 . Support  118  includes a wall  120  that extends between an end  122  and an end  124 . Wall  120  includes a surface  126  and a surface  128  that extend between ends  122 ,  124 . In some embodiments, wall  120  may extend in alternate configurations between ends  122 ,  124 , such as, for example, linear, arcuate, offset, staggered and/or angled portions. 
     Wall  120  includes an extension, such as, for example, a leg  130 . Leg  130  extends from end  122 . Leg  130  is oriented substantially perpendicular to axis X 1 . In some embodiments, leg  130  may be variously oriented relative to axis X 1 , such as, for example, transverse and/or angled, which may include acute and obtuse orientations. In some embodiments, leg  130  may have various configurations, for example, round, oval, rectangular, tapered, polygonal, irregular, offset, staggered, uniform and non-uniform. 
     Leg  130  includes a surface  132  that defines a recess  134 . Recess  134  is configured for engagement with rod  36  to facilitate connection of member  16  with member  116  and adjacent bone fasteners, as described herein. In some embodiments, the geometry of recess  134  may be arcuate to facilitate engagement with rod  36 . In some embodiments, surface  132  is smooth or even. In some embodiments, surface  132  may be rough, textured, porous, semi-porous, dimpled and/or polished. 
     Leg  130  includes a surface  136  that defines a mating element, such as, for example, a detent  138 . Detent  138  is configured for a mating engagement with various surgical instruments in a quick release configuration to facilitate the interchangeability of connector  12  with surgical instruments, as described herein. In some embodiments, detent  138  includes a circular configuration. In some embodiments the cross section geometry of detent  138  may have various configurations, such as, for example, oval, oblong, triangular, polygonal having planar or arcuate side portions, irregular, uniform, non-uniform, consistent, variable, horseshoe shape, U-shape or kidney bean shape. In some embodiments, surface  136  may have alternate surface configurations, such as, for example, rough, threaded for connection with surgical instruments, arcuate, undulating, porous, semi-porous, dimpled, polished and/or textured. Detents  138  are configured for releasable engagement with a surgical instrument to manipulate tissue such that movement of the receiver relative to a shaft of the fastener is resisted and/or prevented. 
     Wall  120  includes an extension, such as, for example, a leg  140 , disposed in a spaced apart relation with leg  130 . In some embodiments, leg  140  extends from end  124 . Leg  140  is oriented substantially perpendicular to axis X 1 . In some embodiments, leg  140  may be variously oriented relative to axis X 1 , such as, for example, transverse and/or angled. 
     Leg  140  includes a surface  142  that defines a recess  144 . Recess  144  is arcuate to facilitate engagement with rod  36 . In some embodiments, surface  142  is smooth or even. In some embodiments, surface  142  may be rough, textured, porous, semi-porous, dimpled and/or polished. 
     Leg  140  includes a surface  146  that defines a mating element, such as, for example, a detent  148 . Detent  148  is configured for a mating engagement with various surgical instruments in a quick release configuration, as described herein, to facilitate the interchangeability of connector  12  with surgical instruments, as described herein. In some embodiments, detent  148  includes a circular configuration. In some embodiments, detent  148  may have various configurations, such as, for example, oval, oblong, triangular, polygonal having planar or arcuate side portions, irregular, uniform, non-uniform, consistent, variable, horseshoe shape, U-shape or kidney bean shape. In some embodiments, surface  146  may have alternate configurations, such as, for example, rough, threaded for connection with surgical instruments, arcuate, undulating, porous, semi-porous, dimpled, polished and/or textured. 
     Wall  120  includes an extension  150 . Extension  150  extends from wall  120  between ends  122 ,  124 . Extension  150  connects legs  130 ,  140 . Extension  150  is oriented substantially parallel to axis X 1 . In some embodiments, extension  150  may be variously oriented relative to axis X 1 , such as, for example, transverse and/or angled. Wall  120  includes an extension  160 . Extension  160  extends from wall  120  between ends  122 ,  124  in a spaced apart relation relative to extension  150 . Extension  160  connects legs  130 ,  140 . Extension  160  is oriented substantially parallel to axis X 1 . In some embodiments, extension  160  may be variously oriented relative to axis X 1 , such as, for example, transverse and/or angled. 
     Wall  120  includes an inner surface  172  that defines an axial cavity  174  extending between surfaces  126 ,  128 . Cavity  174  is configured for disposal of a coupling member, such as, for example, a set screw  180 . In some embodiments, set screw  180  is integrally connected with member  116 . Set screw  180  is configured to fix support  116  with the receiver of a bone fastener, as described herein. Set screw  180  includes a surface  192 . Surface  192  is configured to engage a surface  54  of rod  36  to connect support  16  with support  116  forming connector  12 . 
     Spinal correction system  10  includes a bone fastener, such as, for example, a multi-axial screw (MAS)  200 , as shown in  FIG. 3 . MAS  200  is configured for engagement with tissue, as described herein. MAS  200  includes a receiver  202  having a pair of spaced apart arms  204 ,  204   a.  Receiver  202  is configured for engagement with member  16  and/or member  116 , as described herein. 
     Arms  204 ,  204   a  include an inner surface that defines a U-shaped passageway  206 . Passageway  206  is configured for disposal of rod  36 , as described herein. In some embodiments, all or only a portion of passageway  206  may have alternate cross section configurations, such as, for example, oval, oblong, triangular, square, polygonal, irregular, uniform, non-uniform, offset, staggered, and/or tapered. In some embodiments, arms  204 ,  204   a  may be disposed at alternate orientations, relative to a longitudinal axis of MAS  200 , such as, for example, transverse, perpendicular and/or other angular orientations such as acute or obtuse, co-axial and/or may be offset or staggered. 
     The inner surface of receiver  202  includes a thread form configured for engagement with set screw  80  and/or set screw  180 . Set screws  80 ,  180  are threaded with receiver  202  to attach, fix and/or lock member  16  and/or member  116  with MAS  200  attached with tissue to facilitate connection of the tissue with surgical instruments for correction treatment, as described herein. 
     MAS  200  includes a shaft  208  configured for penetrating tissue. Shaft  208  has a cylindrical cross-sectional configuration and includes an outer surface having an external thread form. In some embodiments, the external thread form may include a single thread or a plurality of discrete threads. In some embodiments, other engaging structures may be located on shaft  208 , such as, for example, a nail configuration, barbs, expanding elements, raised elements and/or spikes to facilitate engagement of shaft  208  with tissue. 
     In some embodiments, all or only a portion of shaft  208  may have alternate cross section configurations, such as, for example, oval, oblong, triangular, square, polygonal, irregular, uniform, non-uniform, offset, staggered, undulating, arcuate, variable and/or tapered. In some embodiments, the outer surface of shaft  208  may include one or a plurality of openings. In some embodiments, all or only a portion of the outer surface of shaft  208  may have alternate surface configurations to enhance fixation with tissue, such as, for example, rough, arcuate, undulating, mesh, porous, semi-porous, dimpled and/or textured. In some embodiments, all or only a portion of shaft  208  may be disposed at alternate orientations, relative to its longitudinal axis, such as, for example, transverse, perpendicular and/or other angular orientations such as acute or obtuse, co-axial and/or may be offset or staggered. In some embodiments, all or only a portion of shaft  208  may be cannulated. 
     Spinal correction system  10  includes a bone fastener, such as, for example, a dual rod multi-axial screw (DRMAS)  220 , as shown in  FIG. 4 . DRMAS  220  is configured for engagement with tissue, as described herein. DRMAS  220  includes a receiver  222 . Receiver  222  includes a spaced apart arms  226 ,  226   a,    226   b.  Arms  226 ,  226   a  include an inner surface that defines a U-shaped passageway  228 . The inner surface of passageway  228  includes a thread form configured for engagement with set screws  80  and/or  180 . Set screws  80 ,  180  are threaded with arms  226 ,  226   a  to attach, fix and/or lock member  16  and/or member  116  with receiver  222 , as described herein. Spaced apart arms  226   a,    226   b  include an inner surface that defines a U-shaped passageway  230  disposed adjacent to passageway  228 . The inner surface of arms  226   a,    226   b  includes a thread form configured for engagement with set screw  80  and/or set screw  180  to attach, fix and/or lock member  16  and/or member  116  with receiver  222 . 
     DRMAS  220  includes a shaft  232 , similar to shaft  208 , configured for penetrating tissue. In some embodiments, one or more of the bone fasteners described herein can include posted screws, pedicle screws, uni-axial screws, side loading screws, sagittal adjusting screws, transverse sagittal adjusting screw, sagittal angulation screws, uni-planar screws, facet screws, fixed screws, tissue penetrating screws, conventional screws, expanding screws, wedges, anchors, buttons, clips, snaps, friction fittings, compressive fittings, expanding rivets, staples, nails, adhesives, posts, fixation plates and/or posts. In some embodiments, one or more of the bone fasteners may be engaged with tissue in various orientations, such as, for example, series, parallel, offset, staggered and/or alternate vertebral levels. 
     Spinal correction system  10  includes a surgical instrument, such as, for example, a compressor/distractor  250 , as shown in  FIG. 5 . Compressor/distractor  250  includes a longitudinal element, such as, for example, a rack  252 . Rack  252  extends between an end  254  and an end  256  defining a longitudinal axis A 1 . In some embodiments, rack  252  includes an outer surface  258  having a plurality of teeth, such as, for example, splines  260  engageable with an arm, as described herein. 
     Rack  252  includes an arm  262  extending from end  254 . Arm  262  includes a part  264  and a part  266 . Part  264  extends between an end  268  and an end  270 . End  268  is configured for connection with rack  252 . In some embodiments, part  264  is monolithically formed with rack  252 . In some embodiments, end  268  is attached with rack  252  with, for example, clips, hooks, adhesives and/or flanges. In some embodiments, all or only a portion of part  264  may include cross section configurations, such as, for example, oval, oblong, triangular, square, polygonal, irregular, uniform, non-uniform, offset, staggered, undulating, arcuate, variable and/or tapered. 
     End  270  includes a surface that defines a cavity  272 . Cavity  272  is configured for disposal of part  266 . In some embodiments, cavity  272  includes a pin hinge  274  configured to facilitate a pivotable connection with part  266 . Pin hinge  274  facilitates rotation of part  266  relative to part  264 . Part  266  is configured to rotate relative to part  264 , in the directions shown by arrows A in  FIG. 5 . In some embodiments, part  264  includes a locking mechanism  276  configured to fix part  266  relative to part  264 . 
     Part  266  extends between an end  278  and an end  280  and defines an axis L 2 . End  278  includes a surface that defines a cavity  282 . Cavity  282  is configured for disposal of pin  274  and connection with part  264 , as described herein. End  280  includes an extension, such as, for example, a rod  284 . In some embodiments, rod  284  extends transverse to axis L 2 . In some embodiments, all or only a portion of rod  284  may be disposed at alternate orientations, relative to axis L 2 , such as, for example, perpendicular and/or other angular orientations such as acute or obtuse, co-axial and/or may be offset or staggered. Rod  284  includes a surface  286  configured for engagement with a body, such as, for example, a sleeve  290 , as shown in  FIGS. 6-8 . In some embodiments, surface  286  includes a circumferential lip  288  configured to resist and/or prevent disengagement of rod  284  from sleeve  290 . Rod  284  is configured to facilitate rotation of sleeve  290  relative to arm  262 , in the directions shown by arrows D and arrows E in  FIG. 6  in a non-locking orientation, as described herein. 
     Sleeve  290  extends between an end  292  and an end  294  defining an axis L 3 . End  292  is connected with rod  284  by a lock  296 . Sleeve  290  is disposable in a non-locking orientation for rotation relative to rod  284 , in the direction shown by arrows D in  FIG. 6 . Lock  296  is configured to fix sleeve  290  relative to rod  284  in a locked orientation to resist and/or prevent rotation of sleeve  290  relative to rod  284 , as described herein. 
     Lock  296  includes a collar  298  that extends between an end  302  and an end  304 . End  302  includes a circumferential flange  306  configured for engagement with a screw  324  to facilitate translation of collar  298 , as described herein. Engagement of flange  306  with screw  324  facilitates translation of collar  298  into the non-locking orientation. 
     Screw  324  includes a head  326  and a threaded shaft  328 . In some embodiments, head  326  includes a hexagonal cross-section. In some embodiments, head  326  may have alternative cross-sections, such as, for example, rectangular, polygonal, hexalobe, oval, irregular, cruciform, phillips, square, polygonal or star cross sectional configuration. 
     Screw  324  includes a circumferential ring  340  configured to engage flange  306 . Ring  340  is disposed between head  326  and shaft  328 . Engagement of flange  306  with collar  298  facilitates translation of collar  298  into the non-locking orientation. In some embodiments, screw  324  includes a knob  330 . Knob  330  includes a gripping surface  332  configured to facilitate rotation of screw  324 . Knob  330  includes a surface  333  that defines a cavity  334 . Cavity  334  is configured for a mating engagement with head  326 . In some embodiments, cavity  334  includes a hexagonal cross-section to mate with head  326 . In some embodiments, cavity  334  may have alternative cross-sections, such as, for example, rectangular, polygonal, hexalobe, oval, irregular, cruciform, phillips, square, polygonal or star cross sectional configuration. 
     Shaft  328  includes a surface  335  configured to engage surface  286  of rod  284 . Rotation of screw  324  in a clockwise direction causes screw to translate into engagement with rod  284  to fix rod  284  with sleeve  290  in the locked orientation to resist and/or prevent rotation of sleeve  290  relative to rod  284 . Surface  335  is configured to apply a force to rod  284  to fix sleeve  290  relative to rod  284 . Engagement of screw  324  with rod  284  is configured to fix rod  284  between screw  324  and collar  298  preventing rotation of sleeve  290  about rod  284 . Rotation of screw  324  in a counter clockwise direction causes screw to translate out of engagement with rod  284  into the non-locking orientation to allow rotation of sleeve  290  relative to rod  284 . 
     Collar  298  includes a surface  308  that defines an opening  310 . Opening  310  is configured for disposal of rod  284 . In some embodiments, all or only a portion of opening  310  may include cross section configurations, such as, for example, oval, oblong, triangular, square, polygonal, irregular, uniform, non-uniform, offset, staggered, undulating, arcuate, variable and/or tapered. Collar  298  includes a surface  312  that defines a cavity  314 . Cavity  314  is configured for disposal of a shaft  300 , as described herein. In some embodiments, cavity  314  extends along axis L 3 . In some embodiments, all or only a portion of cavity  314  may be disposed at alternate orientations, relative to axis L 3 , such as, for example, perpendicular and/or other angular orientations such as acute or obtuse, co-axial and/or may be offset or staggered. 
     End  304  includes a surface  316  that defines an engagement surface, such as, for example, a splined surface  318 . Sleeve  290  is disposable in a non-locking orientation for rotation relative to axis L 3 , in the directions shown by arrows E in  FIG. 6 . Splines  318  are engageable with a surface of sleeve  290  to fix sleeve  290  relative to arm  262  to resist and/or prevent rotation of sleeve  290 , in the directions shown by arrows E in  FIG. 6 . Locking of rod  284  with sleeve  290  causes splines  318  to translate axially into engagement with sleeve  290  to fix sleeve  290  relative to arm  266  and axis L 3 . Splines  318  are configured for translation in a second, opposite direction out of engagement with sleeve  290  to facilitate rotation of sleeve  290  relative to arm  266  and axis L 3 . 
     Shaft  300  includes a surface  344  that defines an opening  346 . Opening  346  is disposed in alignment with opening  310  to receive and support rod  284 . Shaft  300  includes a surface  348  that defines a groove  350 . Groove  350  is circumferentially disposed about surface  348 . Groove  350  is configured for disposal of pins  352  disposed with sleeve  290 . Pins  352  and groove  350  engage to prevent shaft  300  from translating while allowing shaft  300  to rotate relative to sleeve  290 . 
     End  294  of sleeve  290  includes a surface  360  that defines a cavity  362 , as shown in  FIGS. 8-12 . Cavity  362  includes walls  364   a,    364   b,    364   c  and  364   d  that define a tubular configuration. In some embodiments, cavity  362  may have alternative cross-sections, such as, for example, rectangular, polygonal, oval, or irregular. Cavity  362  includes a portion  366  and a portion  368 . Portion  366  includes a surface  370  that defines a recess  372 . Recess  372  includes a female receptacle, such as, for example, a channel  374 . Channel  374  is configured for disposal of head  182  of set screw  180 , as shown in  FIG. 10 . Portion  368  includes a surface  376  configured for a mating engagement with support  118 . Portion  366  merges with portion  368  at a surface  378  that defines a ledge  380 . Ledge  380  is configured to contact wall  120 . Portions  366 ,  368  are configured to guide support  118  into cavity  362 . Cavity  362  is configured to capture and engage support  118 , as described herein. 
     Wall  364   b  includes a surface  382  that defines an elongate opening  384 . Opening  384  is configured for moveable disposal of an arm, such as, for example, a latch  400 , as described herein. Wall  364   d  includes a surface  386  that defines an elongate opening  388 . Opening  388  is configured for moveable disposal of an arm, such as, for example, a latch  402 , as described herein. Latches  400 ,  402  are configured to engage detents  138 ,  148  to capture support  118 . 
     Latches  400 ,  402  are configured for relative movement to capture support  116  in a quick release configuration, as described herein. Latch  400  extends between an end  404  and an end  406 . End  404  includes a gripping surface  408  configured to facilitate manipulation of latch  400 . End  406  includes a capture element  410 . Capture element  410  is configured to engage detent  138 . Latch  400  is connected with sleeve  290  by a spring  412 . Spring  412  is configured to resiliently bias latch  400  in the closed configuration, as shown in  FIG. 11 . 
     Latch  402  extends between an end  414  and an end  416 . End  414  includes a gripping surface  418  configured to facilitate manipulation of latch  402 . End  416  includes a capture element  420 . Capture element  420  is configured to engage detent  148 . Latch  402  is connected with sleeve  290  by a spring  422 . Spring  422  is configured to resiliently bias latch  402  in the closed configuration, as shown in  FIG. 11 . In some embodiments, latches  400 ,  402  are resiliently biased to a closed configuration to capture support  118 , as shown in  FIGS. 11 , and manipulable to an open configuration, as shown in  FIGS. 9 and 10 . Latches  400 ,  402  engage support  118  in a quick release configuration such that sleeves  290 ,  290   a  and supports  118  are connectable in releasably fixed engagement via biased latches  400 ,  402  to facilitate intra-operative connection, as described herein. In some embodiments, the quick release configuration of spinal correction system  10  may include threaded connection, clips, dovetail connection, adhesive, key/keyslot, friction fit and/or pressure fit. 
     Rack  252  includes an arm  562 . Arm  562  is configured for axial translation along axis A 1  relative to arm  262 . Arm  562  includes a part  564  and a part  566 . Part  564  extends between an end  568  and an end  570 . End  568  is configured for connection with rack  252 . In some embodiments, end  586  includes a lock  600 . Lock  600  is configured for manipulation in various orientations to fix arm  562  in various configurations relative to arm  262  along rack  252 . In some embodiments, lock  600  is oriented to allow translation of arm  562  towards arm  262 . In some embodiments, lock  600  is oriented to allow translation of arm  462  away from arm  262 . In some embodiments, lock  600  is oriented to allow translation of arm  462  towards and away from arm  262 . In some embodiments, lock  600  is oriented to resist and/or prevent translation of arm  562  to fix arm  562  with rack  252 . In some embodiments, end  668  is attached with rack  252  via, for example, clips, hooks, adhesives and/or flanges. 
     End  570  includes a surface that defines a cavity  572 . Cavity  572  is configured for disposal of part  566 , similar to part  266  described herein. Cavity  572  includes a pin hinge  574  configured to facilitate a pivotable connection with part  566 . Pin hinge  574  facilitates rotation of part  566  relative to part  564 . Part  566  is configured to rotate relative to part  564 , in the directions shown by arrows B in  FIG. 5 . Part  564  includes a locking mechanism  576  configured to fix part  566  relative to part  564 . 
     Part  566  extends between an end  578  and an end  580  and defines an axis L 4 . End  578  includes a surface that defines a cavity  582 . Cavity  582  is configured for disposal of pin hinge  574  and connection with part  564 , as described herein. End  580  includes a rod  584 , similar to rod  284  described herein. Rod  584  includes a surface  586  configured for engagement with a sleeve  290   a,  similar to sleeve  290  described herein. Surface  586  includes a circumferential lip  588  configured to resist and/or prevent disengagement of rod  584  from sleeve  290   a,  similar to that described herein. Rod  584  is configured to facilitate rotation of sleeve  290   a  relative to arm  562  between a non-locking orientation and a locked orientation, similar to sleeve  290  described herein. 
     In some embodiments, surgical instrument  250  is configured for a direct connection with the receiver of a fixed angle bone fastener  100 , as shown in  FIG. 13 . In some embodiments, sleeve  290  and/or sleeve  290   a  are configured for engagement with the receiver of bone fastener  100  to direct a compression and/or distraction load along a single bone fastener. 
     In assembly, operation and use, spinal correction system  10  including spinal construct  12  and surgical instrument  250 , similar to the systems and methods described with regard to  FIGS. 1-13 , is employed with a surgical procedure, such as, for example, a PSO for treatment of a spine of a patient including vertebrae V, as shown in  FIGS. 14-21 . Spinal correction system  10  may also be employed with other surgical procedures, such as, for example, discectomy, laminectomy, fusion, laminotomy, laminectomy, nerve root retraction, foramenotomy, facetectomy, decompression, spinal nucleus or disc replacement and bone graft and implantable prosthetics including plates, rods, and bone engaging fasteners for securement of spinal construct  12 . 
     Spinal correction system  10  is employed with a PSO procedure for treatment of an applicable condition or injury of an affected section of a spinal column and adjacent areas within a body. For example, vertebrae V includes a vertebral level V 1 , a vertebral level V 2  and a vertebral level V 3 . Diseased and/or damaged vertebrae and intervertebral discs are disposed at vertebrae V 2  between vertebrae V 1  and V 3 . In some embodiments, components of spinal correction system  10  are configured for insertion with a vertebral space to space apart articular joint surfaces, provide support and maximize stabilization of vertebrae V. 
     In use, to treat the affected section of vertebrae V, a medical practitioner obtains access to a surgical site including vertebrae V, as shown in  FIG. 14 , in any appropriate manner, such as through incision and retraction of tissues. In some embodiments, spinal correction system  10  may be used in any existing surgical method or technique including open surgery, mini-open surgery, minimally invasive surgery and percutaneous surgical implantation, whereby vertebrae V is accessed through a mini-incision, or sleeve that provides a protected passageway to the area. 
     An incision is made in the body of a patient and a cutting instrument (not shown) creates a surgical pathway for implantation of components of spinal correction system  10 . A preparation instrument (not shown) can be employed to prepare tissue surfaces of vertebrae V, as well as for aspiration and irrigation of a surgical region. 
     MAS screws  200  are engaged with vertebrae V along a lateral side L of vertebrae V, as shown in  FIG. 15 . In some embodiments, MAS screws  200  are disposed in pairs  200   a,    200   b  alongside L. In some embodiments, pair  200   a  is disposed inferior to vertebra V 2  and pair  200   b  is disposed superior to vertebra V 2 . DRMAS  220  are engaged along a contralateral side CL of vertebrae V, as shown in  FIG. 15 . In some embodiments, DRMAS screws  220  are disposed in pairs  220   a,    220   b  alongside CL. In some embodiments, pair  220   a  is disposed inferior to vertebra V 2  and pair  220   b  is disposed superior to vertebra V 2 . The receivers of MAS  200  and DRMAS  220  are configured to rotate within six degrees relative to the shafts. 
     Support  18  is engaged with pair  200   a  such that support  18  is disposed adjacent vertebra V 2  and rod  36  extends in an inferior orientation to an adjacent MAS  200 , as shown in  FIG. 16 . Set screw  80  is engaged with receiver  202  disposed adjacent vertebrae V 2 . Support  18  is engaged with pair  200   b  such that support  18  is disposed adjacent vertebra V 2  and rod  36  extends in a superior orientation to an adjacent MAS  200 . Set screw  80  is engaged with receiver  202  disposed adjacent vertebrae V 2 . 
     Support  18  is engaged with pair  220   a  such that support  18  is disposed adjacent vertebra V 2  and rod  36  extends in an inferior orientation to an adjacent MAS screw  200 . Set screw  80  is engaged with receiver  222  disposed adjacent vertebrae V 2 . Support  18  is engaged with pair  220   b  such that support  18  is disposed adjacent vertebra V 2  and rod  36  extends in a superior orientation to an adjacent MAS  200 . Set screw  80  is engaged with receiver  222  disposed adjacent vertebrae V 2 . 
     A surgical instrument, such as, for example, a driver is connected with set screw  80  and/or set screw  180  to facilitate engagement of supports  18 ,  118 . Support  118  is engaged with pair  200   a  such that set screw  180  is engaged with the adjacent MAS screw  200  receiver  202  and rod  36 , as shown in  FIG. 17 . Support  118  is engaged with pair  200   b  such that set screw  180  is engaged with the adjacent receiver  202  and rod  36 . Support  118  is engaged with pair  220   a  such that set screw  180  is engaged with the adjacent DRMAS  220  receiver  222  and rod  36 . Support  118  is engaged with pair  220   b  such that set screw  180  is engaged with the adjacent DRMAS  220  receiver  222  and rod  36 . 
     Engagement of supports  18 ,  118  with rod  36  and the adjacent bone fasteners construct connector  12 . Attachment of connectors  12  with pairs  200   a,    200   b,    220   a,    220   b  resists and/or prevents movement of the receivers relative to the shafts and/or vertebrae attached therewith. In some embodiments, movement of the receivers relative to the shafts and/or vertebrae can be prevented in one or a plurality of degrees of freedom of the fasteners, as described herein. 
     Surgical instrument  250  is connected with supports  118  disposed alongside CL of vertebrae V, as shown in  FIG. 18 . In some embodiments, part  266  and/or part  566  are rotatable relative to arm  262 , arm  562 , rack  252 , the spinal constructs and/or vertebrae V to orient sleeve  290  and/or sleeve  290   a  in a selected orientation to capture one or more connector  12 . In some embodiments, part  266  is fixed in a selected orientation with locking mechanism  276  and part  566  is fixed in a selected orientation with locking mechanism  576 , as described herein. Sleeves  290 ,  290   a  are translated over supports  118  such that capture elements  406 ,  416  are engaged with detents  138 ,  148  in a quick release configuration, as described herein. 
     In some embodiments, a surgical instrument, such as, for example, an osteotome is utilized to facilitate removing all or a portion of vertebra V 2  and adjacent intervertebral disc tissue to define a vertebral space VS, as shown in  FIG. 19 . In some embodiments, vertebral space VS can include posterior portions of the spine, such as, for example, pedicles, laminae and/or spinous process. In some embodiments, a wedge portion of bone and/or other tissue is removed from a selected vertebra and adjacent intervertebral disc tissue remains intact. 
     Lock  600  is manipulated to axially translate arm  562  along rack  252  relative to arm  262  to facilitate compression and/or distraction of vertebrae V. Translation of arm  562  relative to arm  262  along rack  252 , in a direction shown by arrow N in  FIG. 20 , distracts vertebrae V to open vertebral space VS. In some embodiments, a spinal implant, such as, for example, an intrabody implant  700  is disposed within vertebral space VS, as shown in  FIG. 20 . In some embodiments, intrabody implant  700  is configured to preserve anterior height and maintain alignment of vertebrae V. Intrabody implant  700  provides a fulcrum about which vertebrae V 1 , V 2  are pivoted by surgical instrument  250 . 
     Surgical instrument  250  is manipulated to pivot vertebrae V 1 , V 2  about intrabody implant  700 . Translation of arm  562 , in a direction shown by arrow M in  FIG. 21 , is configured to compress vertebrae V to achieve correction, for example, a selected lordosis. In some embodiments, surgical instrument  250  manipulates vertebrae V during a surgical correction treatment to rotate, displace, pull, twist or align vertebrae V to a selected orientation for sagittal, coronal and/or axial correction. In some embodiments, surgical instrument  250  applies derotation forces to vertebrae V for correction of vertebrae V. 
     Upon completion of a procedure, as described herein, the surgical instruments, assemblies and non-implanted components of spinal correction system  10  are removed and the incision(s) are closed. One or more of the components of spinal correction system  10  can be made of radiolucent materials such as polymers. Radiomarkers may be included for identification under x-ray, fluoroscopy, CT or other imaging techniques. In some embodiments, the use of surgical navigation, microsurgical and image guided technologies may be employed to access, view and repair spinal deterioration or damage, with the aid of spinal correction system  10 . In some embodiments, spinal correction system  10  may include one or a plurality of plates, connectors and/or bone fasteners for use with a single vertebral level or a plurality of vertebral levels. 
     In some embodiments, spinal correction system  10  includes one or a plurality of alternate surgical instruments, each configured for mating engagement in a quick release configuration with spinal constructs, as described herein. This configuration facilitates the interchangeability of the spinal constructs with the alternate surgical instruments. In some embodiments, spinal correction system  10  includes one or a plurality of alternate surgical instruments, such as, for example, inserters, extenders, reducers, spreaders, distracters, blades, retractors, clamps, forceps, elevators and drills, which may be alternately sized and dimensioned, and arranged as a kit. 
     In some embodiments, spinal correction system  10  includes an agent, which may be disposed, packed, coated or layered within, on or about the components and/or surfaces of spinal correction system  10 . In some embodiments, the agent may include bone growth promoting material, such as, for example, bone graft to enhance fixation of the components and/or surfaces of spinal correction system  10  with vertebrae. In some embodiments, the agent may include one or a plurality of therapeutic agents and/or pharmacological agents for release, including sustained release, to treat, for example, pain, inflammation and degeneration. 
     In one embodiment, as shown in  FIGS. 22-31 , spinal correction system  10 , similar to the systems and methods described with regard to  FIGS. 1-21 , includes a spinal construct, such as, for example, a connector  1412 , similar to the connectors described herein. 
     Connector  1412  is engageable with fasteners and a surgical instrument to manipulate tissue, similar to that described herein. Connector  1412  includes a member  1416 . Member  1416  includes a body, such as, for example, a support  1418 . Support  1418  includes a wall  1420  that extends between an end  1422  and an end  1424 . Wall  1420  extends parallel to a longitudinal axis X 2  defined by a rod  1442 , as described herein. Wall  1420  includes a surface  1426  that defines a channel  1428 . Channel  1428  is configured for disposal of an actuator, as described herein. 
     Wall  1420  includes an extension, such as, for example, a leg  1430 . Leg  1430  extends from end  1422 . Leg  1430  is pivotally connected with end  1422  with a pin to facilitate rotation of leg  1430  relative to support  1420 , as described herein. Leg  1430  includes a surface  1432  that defines a portion of a support cavity  1434 . Cavity  1434  is configured to capture at least a portion of a bone fastener  1650 , as described herein. Surface  1432  is configured to surround and/or engage a portion of a receiver of bone fastener  1650 . Surface  1432  defines a tab  1436  projecting into cavity  1434  and configured for releasably capturing bone fastener  1650 . 
     Leg  1430  includes a surface  1438  that defines an opening  1440 . Surface  1438  is configured for engagement with a rod  1442 , as described herein. Leg  1430  is configured for relative movement to capture MAS  1650 , as described herein. In some embodiments, leg  1430  is resiliently biased in an open configuration and is movable to a closed configuration to capture bone fastener  1650 , as described herein. 
     Wall  1420  includes an extension, such as, for example, a leg  1450 . Leg  1450  extends from end  1424 . Leg  1450  is pivotally connected with end  1424  with a pin to facilitate rotation of leg  1450  relative to support  1420 , as described herein. Leg  1450  includes a surface  1452  that defines a portion of support cavity  1434 , as described herein. Surface  1452  is configured to surround and/or engage a portion of a receiver of bone fastener  1650 . Surface  1452  defines a tab  1456  projecting into cavity  1434  and configured for releasably capturing bone fastener  1650 . Leg  1450  includes a surface  1458  that defines an opening  1460 . Surface  1458  is configured for engagement with rod  1442 , as described herein. 
     Leg  1450  is configured for relative movement to capture bone fastener  1650 , as described herein. In some embodiments, leg  1450  is resiliently biased in an open configuration and is movable to a closed configuration to capture bone fastener  1650 , as described herein. 
     Rod  1442  extends between an end  1470  and an end  1472 . Rod  1442  is configured for engagement with a rod contact member, as described herein. In some embodiments, rod  1442  includes an outer threaded surface engageable with leg  1430  and/or leg  1450 . In some embodiments, rod  1442  is configured to connect a receiver of one bone fastener with a receiver of an adjacent bone fastener, as described herein. 
     Member  1416  includes a part, such as, for example, a collar  1480 . Collar  1480  includes a surface  1482  that defines an opening  1484 . Opening  1484  is configured for slidable disposal of leg  1430 . Collar  1480  includes a surface  1486  that defines an opening  1488 . Opening  1488  is configured for slidable disposal of leg  1450 . Collar  1480  includes an extension, such as, for example, a rod contact member  1490 . Rod contact member  1490  includes a surface  1492  configured to engage rod  1442 . Collar  1480  is configured for axial translation relative to legs  1430 ,  1450  to move legs  1430 ,  1450  into a capture configuration to capture bone fastener  1650 . Translation of collar  1480  causes surface  1492  to translate into engagement with rod  1442 . 
     Collar  1480  includes a surface  1494  that defines a channel  1496 . Channel  1496  is in communication with channel  1428 . Channel  1496  is configured for disposal of actuator  1500 . Actuator  1500  extends between an end  1502  and an end  1504 . End  1502  includes a surface  1506  configured for connection with a surgical instrument, such as, for example, a driver. In some embodiments, surface  1506  includes a hexagonal cross-section to facilitate engagement with a surgical tool or instrument. In some embodiments, surface  1506  may have alternative cross-sections, such as, for example, rectangular, polygonal, hexalobe, oval, or irregular. 
     End  1504  is fixedly connected with collar  1480  to axially translate collar  1480  to move legs  1430 ,  1450  into engagement with bone fastener  1650  and engage surface  1492  with rod  1442 . In some embodiments, actuator  1500  includes a spring  1507  configured to bias legs  1430 ,  1450  in an open configuration. Translation of actuator  1500  into support  1420  causes a surface of support  1420  to compress spring  1507  to overcome the bias of spring  1507 . Compression of spring  1507  facilitates translation of collar  1480  along legs  1430 ,  1450  into a capture configuration. 
     Support  1418  includes a surface  1508  that defines a mating element, such as, for example, a slot  1510 . Support  1418  includes a surface  1512  that defines a mating element, such as, for example, a slot  1514 . Slots  1510 ,  1514  are configured for mating engagement with a surgical instrument, as described herein. In some embodiments, slots  1510 ,  1514  include a circular configuration. Slots  1510 ,  1514  are configured for releasable engagement with a surgical instrument to facilitate manipulation of tissue such that movement of a receiver relative to a shaft of bone fastener  1650  is resisted and/or prevented. 
     Connector  1412  includes a member  1516 . Member  1516  includes a body, such as, for example, a support  1518 . Support  1518  includes a wall  1520  that extends between an end  1522  and an end  1524 . Wall  1520  extends parallel to axis X 2 , as shown in  FIG. 22 . Wall  1520  includes a surface  1526  that defines a channel  1528 . Channel  1528  is configured for disposal of an actuator, as described herein. 
     Wall  1520  includes an extension, such as, for example, a leg  1530 . Leg  1530  extends from end  1522 . Leg  1530  is pivotally connected with end  1522  with a pin to facilitate rotation of leg  1530  relative to support  1520 , as described herein. Leg  1530  includes a surface  1532  that defines a portion of a support cavity  1534 . Cavity  1534  is configured to capture at least a portion of bone fastener  1650 , as described herein. Surface  1532  is configured to surround and/or engage a portion of a receiver of bone fastener  1650 . Surface  1532  defines a tab  1536  projecting into cavity  1534  and configured for releasably capturing bone fastener  1650 . 
     Leg  1530  includes a surface  1538  that defines an opening  1540 . Surface  1538  is configured for engagement with a rod  1442 , as described herein. Leg  1530  is configured for relative movement to capture bone fastener  1650 , as described herein. In some embodiments, leg  1530  is resiliently biased in an open configuration and is movable to a closed configuration to capture bone fastener  1650 , as described herein. 
     Wall  1520  includes an extension, such as, for example, a leg  1550 . Leg  1550  extends from end  1524 . Leg  1550  is pivotally connected with end  1524  with a pin to facilitate rotation of leg  1550  relative to support  1520 , as described herein. Leg  1550  includes a surface  1552  that defines a portion of support cavity  1534 , as described herein. Surface  1552  is configured to surround and/or engage a portion of a receiver of bone fastener  1650 . Surface  1552  defines a tab  1556  projecting into cavity  1534  and configured for releasably capturing bone fastener  1650 . 
     Leg  1550  includes a surface  1558  that defines an opening  1560 . Surface  1558  is configured for engagement with rod  1442 , as described herein. Leg  1550  is configured for relative movement to capture bone fastener  1650 , as described herein. In some embodiments, leg  1550  is resiliently biased in an open position and is movable to capture bone fastener  1650 , as described herein. In some embodiments, rod  1442  includes an outer threaded surface engageable with leg  1530  and/or leg  1550 . 
     Member  1516  includes a part, such as, for example, a collar  1580 . Collar  1580  includes a surface  1582  that defines an opening  1584 . Opening  1584  is configured for slidable disposal of leg  1530 . Collar  1580  includes a surface  1586  that defines an opening  1588 . Opening  1588  is configured for slidable disposal of leg  1550 . Rod contact member  1590  includes a surface  1592  configured to engage rod  1442 . 
     Collar  1580  is configured for axial translation relative to legs  1530 ,  1550  to move legs  1530 ,  1550  into a capture configuration to capture bone fastener  1650 . Translation of collar  1580  causes surface  1592  to translate into engagement with rod  1442 . 
     Collar  1580  includes a surface  1594  that defines a channel  1596 . Channel  1596  is in communication with channel  1528 . Channel  1596  is configured for disposal of actuator  1600 . Actuator  1600  extends between an end  1602  and an end  1604 . End  1602  includes a surface  1606  configured for connection with a surgical instrument, such as, for example, a driver. In some embodiments, surface  1606  includes a hexagonal cross-section to facilitate engagement with a surgical tool or instrument. In some embodiments, surface  1606  may have alternative cross-sections, such as, for example, rectangular, polygonal, hexalobe, oval, or irregular 
     End  1604  is fixedly connected with collar  1580  to axially translate collar  1580  to move legs  1530 ,  1550  into engagement with bone fastener  1650  and engage surface  1592  with rod  1442 . In some embodiments, actuator  1600  includes a spring  1607  configured to bias legs  1530 ,  1550  in the open configuration. Translation of actuator  1600  into support  1520  causes a surface of support  1520  to compress spring  1507  to overcome the bias of spring  1507 . Compression of spring  1507  facilitates translation of collar  1580  along legs  1530 ,  1550  into a capture configuration. 
     Bone fastener  1650  is configured for implantation with tissue, as described herein. Bone fastener  1650  includes a receiver  1652  having a pair of spaced apart arms  1654 ,  1654   a.  Receiver  1652  is configured for engagement with connector  1412 , as described herein. Arms  1654 ,  1654   a  include an inner surface that defines a U-shaped passageway  1656 , as shown in  FIG. 23 . Passageway  1656  is configured for disposal of rod  1442 , as described herein. 
     Arm  1654  includes slot  1658  configured for mating engagement with a surgical instrument, as described herein. Arm  1654   a  includes slots  1660  configured for a mating engagement with a surgical instrument, as described herein. In some embodiments, slots  1658 ,  1660  include an elongate configuration. Slots  1658 ,  1660  are configured for releasable engageable with a surgical instrument to facilitate manipulation of tissue such that movement of a receiver relative to a shaft of bone fastener  1650  is resisted and/or prevented. Bone fastener  1650  includes a shaft  1662  configured for penetrating tissue, as described herein. 
     In assembly, operation and use, spinal correction system  10 , similar to the systems and methods described herein, including connector  1412 , as described herein, is employed with a surgical procedure, such as, for example, a PSO procedure for treatment of a spine of a patient including vertebrae V, as shown in  FIGS. 24-31 . Spinal correction system  10  may also be employed with other surgical procedures, such as, for example, discectomy, laminectomy, fusion, laminotomy, laminectomy, nerve root retraction, foramenotomy, facetectomy, decompression, spinal nucleus or disc replacement and bone graft and implantable prosthetics including plates, rods, and bone engaging fasteners for securement of connector  1412 . 
     In use, to treat the affected section of vertebrae V, similar to that described herein, a medical practitioner obtains access to a surgical site including vertebrae V, as shown in  FIG. 31 , in any appropriate manner, such as through incision and retraction of tissues. An incision is made in the body of a patient and a cutting instrument (not shown) creates a surgical pathway for implantation of components of spinal correction system  10 . A preparation instrument (not shown) can be employed to prepare tissue surfaces of vertebrae V, as well as for aspiration and irrigation of a surgical region. Bone fasteners  1650  are engaged with vertebrae V along a lateral side L of vertebrae V. In some embodiments, bone fasteners  1650  are disposed in pairs  1650   a,    1650   b  alongside L. In some embodiments, pair  1650   a  is disposed inferior to vertebra V 2  and pair  1650   b  is disposed superior to vertebra V 2 . 
     Supports  1418 ,  1518  are connected to a surgical instrument, such as, for example, an inserter  1700  and an inserter  1700   a,  similar to inserter  1700  described herein, as shown in  FIGS. 24-29 . Inserter  1700  includes a member, such as, for example, a sleeve  1702 . Sleeve  1702  extends between an end  1704  and an end  1706  defining an axis L 4 . End  1704  includes a surface  1708  that defines an opening  1710 . Opening  1710  is configured for disposal of a driver  1712 , as described herein. Sleeve  1702  includes a surface  1714  that defines a channel  1716 . Channel  1716  is disposed in communication with opening  1710  to facilitate insertion and manipulation of driver  1712 , as described herein. End  1706  includes a surface  1720  that defines a cavity  1722 . Cavity  1722  includes walls  1724   a,    1724   b,    1724   c  and  1724   d  that define a tubular configuration. Cavity  1722  is configured to capture and engage support  1418 , as described herein. 
     Wall  1724   b  includes a surface  1726  that defines an elongate opening  1728 . Opening  1728  is configured for moveable disposal of an arm  1740 , as described herein. Wall  1724   d  includes a surface  1730  that defines an elongate opening  1732 . Opening  1732  is configured for moveable disposal of an arm  1742 , as described herein. Arms  1740 ,  1742  are configured to engage detents  1510 ,  1514  to capture support  1418 . 
     Arms  1740 ,  1742  are configured for relative movement to capture support  1418  in a quick release configuration, as described herein. Arm  1740  extends between an end  1744  and an end  1746 . End  1744  includes a gripping surface  1748  configured to facilitate manipulation of arm  1740 . End  1746  includes a capture element  1750 . Capture element  1750  is configured to engage detent  1510 . Arm  1740  is connected with sleeve  1702  by a spring  1752 . Spring  1752  is configured to resiliently bias arm  1740  in a closed configuration, as shown in  FIG. 26 . 
     Arm  1742  extends between an end  1760  and an end  1762 . End  1760  includes a gripping surface  1764  configured to facilitate manipulation of arm  1742 . End  1762  includes a capture element  1766 . Capture element  1766  is configured to engage detent  1514 . Arm  1742  is connected with sleeve  1702  by a spring  1768 . Spring  1768  is configured to resiliently bias arm  1742  in a closed configuration, as shown in  FIG. 26 . In some embodiments, arms  1740 ,  1742  are resiliently biased in a closed configuration to capture support  1418 , as shown in  FIG. 26 , and in an open configuration, as shown in  FIG. 28 , as described herein. Movement of arms  1740 ,  1742  is configured to engage support  1418  in a quick release configuration such that sleeve  1702  and support  1418  are releasably fixable without tools, via biased arms  1740 ,  1742  to facilitate intra-operative connection, similar to that described herein. 
     Inserter  1700  includes a projection, such as, for example, an extension  1790 . Extension  1790  is disposed offset from axis L 4 , as shown in  FIG. 25 . In some embodiments, extension  1790  may be variously oriented relative to axis L 4 , such as, for example, transverse and/or angled. Extension  1790  extends between an end  1792  and an end  1794 . End  1792  is configured for connection with sleeve  1702 . In some embodiments, extension  1790  is monolithically formed with sleeve  1702 . End  1794  is configured for disposal with passageway  1656  of bone fasteners  1650  to facilitate engagement therewith. 
     Inserters  1700 ,  1700   a  are configured to guide supports  1418 ,  1518  for connection with bone fasteners  1650 . As driver  1712  translates into engagement with actuator  1500 , actuator  1500  causes translation of collar  1480  over legs  1430 ,  1450  to move legs  1430 ,  1450  into a closed configuration. In the closed configuration, legs  1430 ,  1450  engage slots  1658  to capture bone fastener  1650 . Collar  1480  is translated into engagement with rod  1442  to fix rod  1442  with support  1418  and bone fastener  1650 . Similarly, inserter  1700   a  includes an extension  1790   a  and is manipulated to engage support  1518  with bone fastener  1650 . Supports  1418 ,  1518  are connected with bone fasteners  1650  to resist and/or prevent movement of receivers  1652 . In some embodiments, bone fasteners  1650  include 6 degrees of freedom of movement, similar to that described herein, and supports  1418 ,  1518  are connected with bone fasteners  1650  to resist and/or prevent movement of receivers  1652  in 5 of 6 degrees of freedom of movement such that receivers  1652  are free to roll in a medial lateral direction. Inserters  1700 ,  1700   a  include a quick release configuration, as described herein, and are removed from supports  1418 ,  1518 . 
     Referring to  FIGS. 30 and 31 , surgical instrument  250 , as described herein, includes arm  262  connected with a linear part  1866 , similar to part  266  described herein, and arm  562  connected with a linear part  1966 , similar to part  566  described herein. Part  1866  is connected with a sleeve  1890 , similar to sleeve  1700  described herein and part  1966  is connected with a sleeve  1890   a,  similar to sleeve  1700  described herein. 
     Surgical instrument  250  is connected with supports  1418 ,  1518  disposed along a side of vertebrae V, as shown in  FIG. 31 . In some embodiments, part  1866  and/or part  1966  are rotatable relative to arm  262 , arm  562 , rack  252 , the spinal constructs and/or vertebrae V to orient sleeve  1890  and/or sleeve  1890   a  in a selected orientation to capture one or more connectors  1412 . In some embodiments, part  1866  is fixed in a selected orientation with locking mechanism  276  and part  1966  is fixed in a selected orientation with locking mechanism  576 , as described herein. Sleeves  1890 ,  1890   a  are translated over supports  1418 ,  1518  and engaged with slots  1510 ,  1514  in a quick release configuration, as described herein. Slots  1510 ,  1514  are configured for a mating engagement with one or a plurality of alternate surgical instruments in a quick release configuration, as described herein, to facilitate the interchangeability of connectors  1412  with alternate surgical instruments, as described herein. 
     Lock  600  is manipulated to axially translate arm  562  along rack  252  relative to arm  262  to facilitate compression and/or distraction of vertebrae V. Translation of arm  562  relative to arm  262  along rack  252 , in a direction shown by arrow P in  FIG. 31 , distracts vertebrae V to open vertebral space VS. In some embodiments, a spinal implant, such as, for example, an intrabody implant is disposed within vertebral space VS, as described herein. 
     Translation of arm  562 , in a direction shown by arrow O in  FIG. 31 , is configured to compress vertebrae V to achieve correction, for example, a selected lordosis. In some embodiments, surgical instrument  250  manipulates vertebrae V during a surgical correction treatment to rotate, displace, pull, twist or align vertebrae V to a selected orientation for sagittal, coronal and/or axial correction. In some embodiments, surgical instrument  250  applies derotation forces to vertebrae V for correction of vertebrae V. 
     It will be understood that various modifications may be made to the embodiments disclosed herein. Therefore, the above description should not be construed as limiting, but merely as exemplification of the various embodiments. Those skilled in the art will envision other modifications within the scope and spirit of the claims appended hereto.