Patent Publication Number: US-2023132731-A1

Title: Liquid chromatographic system and method of cleaning the same, and computer readable medium

Description:
BACKGROUND OF THE INVENTION 
     Field of the Invention 
     The present disclosure relates to a liquid chromatographic system and a method of cleaning the same, and a computer readable medium. 
     Description of the Background Art 
     Liquid chromatography is a technology for separating a component contained in a sample by introducing a sample to be analyzed into a column together with an eluent which is a mobile phase. The component in the sample separated by liquid chromatography may be analyzed by a mass spectrometer based on a property of that component or the like. 
     WO2017/216934 describes a chromatographic mass spectrometry device including a plurality of streams for a liquid chromatogram for the purpose of improvement in throughput of analysis. The chromatographic mass spectrometry device described in WO2017/216934 includes three flow paths to which a column is connected. In the chromatographic mass spectrometry device described in WO2017/216934, a mass spectrometer is connected to any one of the three flow paths through a selector valve connected thereto. 
     In a liquid chromatographic system such as a chromatographic mass spectrometry device, some of a sample analyzed in preceding analyses may be accumulated as contamination in a needle in an autosampler or a valve or a column in a stream. Such accumulation of contamination is also called carryover. Preceding analyses may be carried over to present analysis, which leads to detection by a mass spectrometry device of a peak derived from a sample which is not essentially a measurement target. Therefore, in the liquid chromatographic system, the stream is cleaned after each analysis. A condition for cleaning, however, has conventionally been different depending on a property of a sample to be measured or a type of a column or a pipe included in a stream, and hence it has been difficult to avoid occurrence of carryover only based on a specific cleaning condition, or in the event of occurrence of carryover, it has been difficult to lessen or eliminate carryover in a short period of time. 
     SUMMARY OF THE INVENTION 
     An object of the present disclosure is to provide a technique to appropriately clean a stream in a liquid chromatographic system. 
     A liquid chromatographic system according to one aspect of the present disclosure includes a first column that separates a sample for each component, a first stream which is an analysis flow path including the first column, one or more cleaning pumps that supply a cleaning solution to the first stream, a memory in which two or more combinations of a cleaning method and a cleaning execution condition are stored, and a processor. The processor is configured to analyze a sample through the first stream and obtain at least one of a result of analysis for quality control of the first stream and information that specifies a sample to be analyzed in the first stream, specify a first combination including an execution condition to which at least one of the result of analysis for quality control and the information corresponds, among the two or more combinations, and drive the one or more cleaning pumps in accordance with the cleaning method included in the first combination. 
     A liquid chromatographic system according to another aspect of the present disclosure includes a first stream including an analysis flow path, one or more cleaning pumps that supply a cleaning solution to the first stream, a processor, and a memory in which one or more analysis conditions and one or more cleaning methods are stored. In the memory, each of the one or more analysis conditions is combined with any one of the one or more cleaning methods. The processor determines to use the first stream for analysis of a sample, and after analysis in accordance with any one analysis condition of the one or more analysis conditions, the processor has the one or more cleaning pumps driven in accordance with one cleaning method combined with the one analysis condition among the one or more cleaning methods. 
     A cleaning method according to one aspect of the present disclosure is a method of cleaning a liquid chromatographic system. The liquid chromatographic system includes a first stream including an analysis flow path including a first analysis column, one or more pumps that supply a liquid to the first stream, and a memory in which two or more combinations of a cleaning method and a cleaning execution condition are stored. The cleaning method includes determining to use the first stream for analysis of a sample, obtaining at least one of a result of analysis for quality control of the first stream and information that specifies a sample to be analyzed in the first stream in response to determination to use the first stream for analysis of the sample, specifying a first combination including an execution condition to which at least one of the result of analysis for quality control and the information corresponds, among the two or more combinations, and driving the one or more pumps in accordance with the cleaning method included in the first combination. 
     A computer readable medium according to one aspect of the present disclosure is a non-transitory computer readable medium having a program recorded thereon. The program, when executed by a processor of a controller, causes the controller to perform determining to use, in a liquid chromatographic system, for analysis of a sample, a first stream including an analysis flow path including a first analysis column, obtaining at least one of a result of analysis for quality control of the first stream and information that specifies a sample to be analyzed in the first stream in response to determination to use the first stream for analysis of the sample, specifying, among two or more combinations of a cleaning method and a cleaning execution condition, a first combination including an execution condition to which at least one of the result of analysis for quality control and the information corresponds, and driving one or more pumps that supply a liquid to the first stream in accordance with the cleaning method included in the first combination. 
     According to the present disclosure, a stream is appropriately cleaned in a liquid chromatographic system. 
     The foregoing and other objects, features, aspects and advantages of the present invention will become more apparent from the following detailed description of the present invention when taken in conjunction with the accompanying drawings. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG.  1    is a diagram of a schematic construction of a liquid chromatographic system. 
         FIGS.  2  and  3    are diagrams each showing a construction of the liquid chromatographic system. 
         FIG.  4    is a block diagram showing the construction of the liquid chromatographic system. 
         FIG.  5    is a diagram exemplifying a state of suction of a sample by a needle. 
         FIG.  6    is a diagram exemplifying a state of injection of the sample sucked by the needle into an injection port. 
         FIG.  7    is a diagram exemplifying a state of injection of an eluent into a column after the sample is guided to the column. 
         FIG.  8    is a diagram exemplifying a state of switching of a stream to be used for analysis from a first stream to a second stream. 
         FIG.  9    is a diagram showing a comparative example of the liquid chromatographic system according to the present embodiment. 
         FIG.  10    is a diagram for illustrating overview of a first cleaning pattern to a fifth cleaning pattern. 
         FIG.  11    is a diagram showing a specific exemplary construction of the first cleaning pattern. 
         FIG.  12    is a diagram showing a specific exemplary construction of the second cleaning pattern. 
         FIG.  13    is a diagram showing a specific exemplary construction of the third cleaning pattern. 
         FIG.  14    is a diagram showing a specific exemplary construction of the fourth cleaning pattern. 
         FIG.  15    is a diagram showing a specific exemplary construction of the fifth cleaning pattern. 
         FIG.  16    is a diagram showing an example in which a flow path is cleaned in the third cleaning pattern and the fourth cleaning pattern during suction of the sample. 
         FIG.  17    is a diagram showing an example in which the flow path is cleaned in the fourth cleaning pattern during injection of the sample. 
         FIG.  18    is a diagram showing an example in which the flow path is cleaned in the second cleaning pattern during analysis of the sample. 
         FIG.  19    is a diagram showing an example in which the flow path is cleaned in the fourth cleaning pattern and the fifth cleaning pattern during analysis of the sample. 
         FIG.  20    is a diagram showing a cleaning pattern that can be selected in first to fourth analysis flow paths. 
         FIG.  21    is a timing chart showing exemplary setting for the cleaning pattern. 
         FIG.  22    is a timing chart showing an exemplary pattern of driving a cleaning pump and a high-pressure pump. 
         FIG.  23    is a flowchart of processing for accepting an input for setting relating to analysis from a user in a liquid chromatographic system  10 . 
         FIG.  24    is a diagram showing an exemplary setting screen. 
         FIG.  25    is a diagram schematically showing an exemplary data configuration in a method file database. 
         FIG.  26    is a flowchart of processing for analyzing a sample in liquid chromatographic system  10 . 
         FIG.  27    is a diagram showing an exemplary screen on which stream information is shown. 
         FIG.  28    is a diagram showing a first modification of the method file database. 
         FIG.  29    is a diagram showing a second modification of the method file database. 
     
    
    
     DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     An embodiment of the present disclosure will be described in detail below with reference to the drawings. The same or corresponding elements in the drawings have the same reference characters allotted and description thereof will not be repeated. 
     &lt;Overall Construction&gt; 
       FIG.  1    is a diagram of a schematic construction of a liquid chromatographic system  10 . In liquid chromatographic system  10 , flow paths  291 A to  291 D used for analysis of a sample are provided. Flow paths  291 A to  291 D include high-pressure valves  180 A to  180 D, respectively. Flow paths  291 A to  291 D are connected to a flow path  292  which leads to a detector  500 . 
     A diverter valve  90  is arranged between flow paths  291 A to  291 D and flow path  292 . 
     Flow paths  291 A to  291 D are each switched between a first flow path which leads to diverter valve  90  via a sample injection device  100  and a second flow path which leads to diverter valve  90  not via sample injection device  100 . Sample injection device  100  includes a needle for injection of a sample. 
     Diverter valve  90  includes ports  91  to  97 . Flow path  291 A is connected to port  91 . Flow path  291 B is connected to port  92 . Flow path  291 C is connected to port  93 . Flow path  291 D is connected to port  94 . Detector  500  is connected to port  95 . A liquid discharge pipe (not shown) is connected to ports  96  and  97 . Port  95  corresponds to a main port. Ports  96  and  97  correspond to a drain port. 
     Diverter valve  90  implements a selector valve that switches an object to be connected to port  95  among ports  91  to  94 . Through diverter valve  90 , any one of flow paths  291 A to  291 D is connected to flow path  292  which leads to detector  500 . 
     A construction of flow path  291 A will be described in detail. 
     Flow path  291 A is a flow path that includes high-pressure valve  180 A and extends from high-pressure valve  180 A in a direction toward a column  230 A. Flow path  291 A is switched by high-pressure valve  180 A between the first flow path which leads to column  230 A via sample injection device  100  and the second flow path which leads to column  230 A not via sample injection device  100 . 
     In flow path  291 A, at least a high-pressure pump  220 A, a cleaning pump  143 A, a cleaning valve  18 A, high-pressure valve  180 A, and column  230 A are arranged. High-pressure valve  180 A is connected to column  230 A. Column  230 A is filled with a stationary phase for separating a component in a sample. 
     High-pressure valve  180 A is connected to high-pressure pump  220 A and cleaning pump  143 A with cleaning valve  18 A being interposed. High-pressure pump  220 A supplies an eluent in a container  210 A to high-pressure valve  180 A. Cleaning pump  143 A supplies a rinse solution in a container  250 A to high-pressure valve  180 A. Any one of high-pressure pump  220 A and cleaning pump  143 A is connected to high-pressure valve  180 A through cleaning valve  18 A. Consequently, the eluent or the rinse solution is supplied to high-pressure valve  180 A. 
     When flow path  291 A is set to the first flow path that passes through sample injection device  100 , the eluent supplied from high-pressure pump  220 A to high-pressure valve  180 A flows to column  230 A via sample injection device  100 . The sample held in sample injection device  100  is sent to column  230 A over the eluent. 
     When flow path  291 A is set to the second flow path that does not pass through sample injection device  100 , the eluent supplied from high-pressure pump  220 A to high-pressure valve  180 A flows to column  230 A without passing through sample injection device  100 . When the sample has already been injected into column  230 A, the eluent is sent from high-pressure valve  180 A to column  230 A through the second flow path. Separation of the sample in column  230 A thus proceeds. 
     Column  230 A is connected to port  91  of diverter valve  90 . When port  91  and port  95  are connected to each other in diverter valve  90 , a component in the sample separated in column  230 A flows to detector  500  via diverter valve  90 . Consequently, the component in the sample separated in column  230 A is analyzed by detector  500  implemented by a mass spectrometer or the like. 
     When cleaning pump  143 A and high-pressure valve  180 A are connected to each other through cleaning valve  18 A, the rinse solution is supplied to high-pressure valve  180 A. High-pressure valve  180 A can allow a flow of the rinse solution to column  230 A through or not through sample injection device  100 . Thus, both of the first flow path leading to column  230 A via sample injection device  100  and the second flow path leading to column  230 A not via sample injection device  100  can be cleaned. 
     When port  91  and port  95  of diverter valve  90  are connected to each other, the rinse solution flows from column  230 A to detector  500  via port  91  and port  95  of diverter valve  90 . Consequently, flow path  292  leading from diverter valve  90  toward detector  500  is also cleaned. When port  91  and ports  96  and  97  of diverter valve  90  are connected to each other, port  91  and ports  96  and  97  of the diverter valve are cleaned. 
     The construction of flow path  291 A is described above in detail. The construction of flow paths  291 B to  291 D will now be described. 
     Flow path  291 B is a flow path that includes high-pressure valve  180 B and extends from high-pressure valve  180 B in a direction toward column  230 B. Flow path  291 B is switched by high-pressure valve  180 B between the first flow path which leads to column  230 B via sample injection device  100  and the second flow path which leads to column  230 B not via sample injection device  100 . 
     In flow path  291 B, at least a high-pressure pump  220 B that sucks an eluent from a container  210 B, a cleaning pump  143 B that sucks a rinse solution from a container  250 B, a cleaning valve  18 B, high-pressure valve  180 B, and column  230 B are arranged. 
     Flow path  291 C is a flow path that includes high-pressure valve  180 C and extends from high-pressure valve  180 C in a direction toward column  230 C. Flow path  291 C is switched by high-pressure valve  180 C between the first flow path which leads to column  230 C via sample injection device  100  and the second flow path which leads to column  230 C not via sample injection device  100 . 
     In flow path  291 C, at least a high-pressure pump  220 C that sucks an eluent from a container  210 C, a cleaning pump  143 C that sucks a rinse solution from a container  250 C, a cleaning valve  18 C, high-pressure valve  180 C, and column  230 C are arranged. 
     Flow path  291 D is a flow path that includes high-pressure valve  180 D and extends from high-pressure valve  180 D in a direction toward column  230 D. Flow path  291 D is switched by high-pressure valve  180 D between the first flow path which leads to column  230 D via sample injection device  100  and the second flow path which leads to column  230 D not via sample injection device  100 . 
     In flow path  291 D, at least a high-pressure pump  220 D that sucks an eluent from a container  210 D, a cleaning pump  143 D that sucks a rinse solution from a container  250 D, a cleaning valve  18 D, high-pressure valve  180 D, and column  230 D are arranged. 
     Thus, flow paths  291 B to  291 D are similar in construction to flow path  291 A. Therefore, detailed description of flow path  291 A that has already been provided is applied as detailed description of flow paths  291 B to  291 D. 
     Flow path  291 A, flow path  291 B, flow path  291 C, and flow path  291 D are also referred to below as a first analysis flow path  291 A, a second analysis flow path  291 B, a third analysis flow path  291 C, and a fourth analysis flow path  291 D, respectively. First analysis flow path  291 A, second analysis flow path  291 B, third analysis flow path  291 C, and fourth analysis flow path  291 D are each switched between the first flow path which leads to diverter valve  90  via sample injection device  100  and the second flow path which leads to diverter valve  90  not via sample injection device  100 . 
     Liquid chromatographic system  10  can switch a flow path to be used for analysis among first analysis flow path  291 A, second analysis flow path  291 B, third analysis flow path  291 C, and fourth analysis flow path  291 D. Therefore, according to liquid chromatographic system  10 , detector  500  can successively analyze various samples. Consequently, liquid chromatographic system  10  can achieve improved analysis efficiency. 
     Liquid chromatographic system  10  further includes cleaning pump  143 A corresponding to first analysis flow path  291 A, cleaning pump  143 B corresponding to second analysis flow path  291 B, cleaning pump  143 C corresponding to third analysis flow path  291 C, and cleaning pump  143 D corresponding to fourth analysis flow path  291 D. Such a construction allows cleaning of the flow paths in various patterns in liquid chromatographic system  10 . 
     For example, when first analysis flow path  291 A is being used for analysis of a sample, a desired flow path among second analysis flow path  291 B, third analysis flow path  291 C, and fourth analysis flow path  291 D can be cleaned. 
     &lt;Construction of Liquid Chromatographic System  10 &gt; 
       FIGS.  2  and  3    are diagrams each showing a construction of liquid chromatographic system  10 . In particular,  FIG.  3    shows a construction of diverter valve  90  included in liquid chromatographic system  10 . 
     As described with reference to  FIG.  1   , liquid chromatographic system  10  includes four high-pressure valves  180 A to  180 D.  FIG.  2    does not show features relating to high-pressure valve  180 C among four high-pressure valves  180 A to  180 D shown in  FIG.  1   . 
     High-pressure valves  180 A to  180 D are connected to a first selector valve  150  and a second selector valve  160 . First selector valve  150  and second selector valve  160  perform a function to select a high-pressure valve involved with suction and injection of a sample among high-pressure valves  180 A to  180 D. First selector valve  150  and second selector valve  160  are each implemented, for example, by a multi-way selector valve. 
     First selector valve  150  is connected to a needle valve  260 . Needle valve  260  is connected to a needle  191  with a sample loop  192  being interposed. Needle  191  is a component like a syringe needle for sucking a sample. Sample loop  192  holds a sample sucked by needle  191 . A needle moving mechanism  190  moves needle  191  in each of directions along three axes orthogonal to one another. 
     Liquid chromatographic system  10  includes injection ports  198 A to  198 D. Injection port  198 A is provided in correspondence with high-pressure valve  180 A. Injection port  198 B is provided in correspondence with high-pressure valve  180 B. Injection port  198 C is provided in correspondence with high-pressure valve  180 C. Injection port  198 D is provided in correspondence with high-pressure valve  180 D. 
     Containers  302 A to  302 C where samples are accommodated are placed on a sample carrier  300 . Needle moving mechanism  190  moves needle  191  for suction of the sample from one of containers  302 A to  302 C. Needle moving mechanism  190  moves needle  191  for injection of the sucked sample into one of injection ports  198 A to  198 D. 
     A needle cleaning pump  20  is further connected to needle valve  260 . 
     Second selector valve  160  is connected to a low-pressure valve  170 . Low-pressure valve  170  is connected to a metering pump  130 . Metering pump  130  is used for suction of a prescribed amount of sample by needle  191 . 
     High-pressure valve  180 A includes ports  181 A to  186 A. Port  181 A is connected to a not-shown liquid discharge pipe. In other words, port  181 A is a drain port. Port  182 A is connected to injection port  198 A. Port  183 A is connected to column  230 A. Port  184 A is connected to high-pressure pump  220 A and cleaning pump  143 A with cleaning valve  18 A being interposed. Port  185 A is connected to first selector valve  150 . Port  186 A is connected to second selector valve  160 . 
     High-pressure valve  180 A includes connection portions  187 A to  189 A. Connection portions  187 A to  189 A switch a state of connection of ports  181 A to  186 A between a first state and a second state. 
     The first state is a state shown in  FIG.  2   . Specifically, the first state is a state in which port  181 A and port  182 A are connected to each other, port  183 A and port  184 A are connected to each other, and port  185 A and port  186 A are connected to each other. 
     In the first state, first selector valve  150  and second selector valve  160  are connected to each other with high-pressure valve  180 A being interposed. In the first state, column  230 A and high-pressure pump  220 A or cleaning pump  143 A are connected to each other with high-pressure valve  180 A being interposed. In the first state, injection port  198 A is connected to port  181 A which is the drain port of high-pressure valve  180 A. 
     The second state is a state resulting from turning of connection portions  187 A to  189 A shown in  FIG.  1    by thirty degrees around the center of high-pressure valve  180 A. Specifically, the second state is a state in which port  182 A and port  183 A are connected to each other, port  184 A and port  185 A are connected to each other, and port  186 A and port  181 A are connected to each other. The second state is shown, for example, in  FIG.  6   . 
     High-pressure valves  180 B to  180 D are similar in construction to high-pressure valve  180 A. High-pressure valves  180 B to  180 D are each switched between the first state and the second state similarly to high-pressure valve  180 A. Further description of high-pressure valves  180 B to  180 D is substantially repetition of the description of the construction of high-pressure valve  180 A. Therefore, further description of high-pressure valves  180 A to  180 D will not be repeated. 
     First selector valve  150  includes ports  151  to  155 . High-pressure valve  180 A is connected to port  151 . High-pressure valve  180 B is connected to port  152 . High-pressure valve  180 C is connected to port  153 . High-pressure valve  180 D is connected to port  154 . Needle valve  260  is connected to port  155 . 
     First selector valve  150  includes a connection portion  158 . Connection portion  158  switches an object to be connected to port  155  among ports  151  to  154 . 
     Needle valve  260  includes ports  261  to  266  and connection portions  267  to  269 . First selector valve  150  is connected to port  261 . Sample loop  192  is connected to port  262 . Needle cleaning pump  20  is connected to port  263 . 
     Needle valve  260  switches a state of connection portions  267  to  269  between the state shown in  FIG.  2    and a state resulting from turning of connection portions  267  to  269  by thirty degrees around the center of needle valve  260  from the state shown in  FIG.  2   . 
     In the state shown in  FIG.  2   , needle  191  is connected to needle valve  260  with sample loop  192  being interposed, needle valve  260  is connected to first selector valve  150 , and first selector valve  150  is connected to high-pressure valve  180 A. Furthermore, high-pressure valve  180 A is connected to second selector valve  160 , and second selector valve  160  is connected to metering pump  130  with low-pressure valve  170  being interposed. Therefore, as needle  191  is moved to any one of containers  302 A to  302 C and then metering pump  130  is driven, needle  191  sucks the sample. 
     As shown in  FIG.  3   , columns  230 A to  230 D are connected to diverter valve  90 .  FIG.  3    shows a state that port  95  formed at the center of diverter valve  90  and port  91  corresponding to column  230 A are connected to each other. At this time, ports  92  to  94  of diverter valve  90  are connected to ports  96  and  97  which are drain ports of diverter valve  90 . 
     In this state, the flow path including column  230 A is connected to detector  500 . Detector  500  can analyze the sample in column  230 A. The flow path including column  230 B leads to a not-shown liquid discharge pipe through ports  96  and  97  of diverter valve  90 . The flow path including column  230 C and the flow path including column  230 D also similarly lead to the not-shown liquid discharge pipe through ports  96  and  97  of diverter valve  90 . 
     As described above, liquid chromatographic system  10  includes a large number of valves. In relation with first selector valve  150  and second selector valve  160 , diverter valve  90  can also be referred to as a third selector valve and needle valve  260  can also be referred to as a fourth selector valve. 
     &lt;Block Diagram of Liquid Chromatographic System  10 &gt; 
       FIG.  4    is a block diagram showing the construction of liquid chromatographic system  10 . As described so far, liquid chromatographic system  10  includes a large number of valves and a large number of pumps. 
     The valves provided in liquid chromatographic system  10  include low-pressure valve  170 , high-pressure valves  180 A to  180 D, cleaning valves  18 A to  18 D, needle valve  260 , first selector valve  150 , second selector valve  160 , and diverter valve  90 . 
     Since the specific construction of these valves has already been described with reference to  FIGS.  1  to  3   , description thereof will not be repeated. 
     The pumps provided in liquid chromatographic system  10  include high-pressure pumps  220 A to  220 D, cleaning pumps  143 A to  143 D, needle cleaning pump  20 , and metering pump  130 . High-pressure pumps  220 A to  220 D suck the eluent from containers  210 A to  210 D, respectively. Cleaning pumps  143 A to  143 D suck the rinse solution from containers  250 A to  250 D, respectively. 
     An identical eluent may be accommodated in containers  210 A to  210 D, or different types of eluents may be accommodated in containers  210 A to  210 D, respectively. An identical rinse solution may be accommodated in containers  250 A to  250 D, or different types of rinse solutions may be accommodated in containers  250 A to  250 D, respectively. 
     Needle cleaning pump  20  sucks the rinse solution from a container  200 . A rinse solution identical to the rinse solution accommodated in containers  250 A to  250 D may be accommodated in container  200 , or a rinse solution different in type from the rinse solution accommodated in containers  250 A to  250 D may be accommodated in container  200 . 
     Sample injection device  100  includes first selector valve  150 , needle valve  260 , needle  191 , and sample loop  192 . 
     Liquid chromatographic system  10  further includes a controller  110 , an input device  120 , a display device  125 , and needle moving mechanism  190 . Since details of needle moving mechanism  190  have already been described with reference to  FIG.  2   , description thereof will not be repeated. 
     Controller  110  includes a processor  111  and a memory  112 . Processor  111  is typically a computing processing unit such as a central processing unit (CPU) or a multi-processing unit (MPU). Processor  111  performs processing of liquid chromatographic system  10  by reading and executing a program stored in memory  112 . 
     Memory  112  is implemented by a non-volatile memory such as a random access memory (RAM), a read only memory (ROM), and a flash memory. So long as a program can be recorded in a non-transitory manner in a format readable by processor  111 , memory  112  may be implemented by a compact disc-read only memory (CD-ROM), a digital versatile disk-read only memory (DVD-ROM), a universal serial bus (USB) memory, a memory card, a flexible disk (FD), a hard disk, a solid state drive (SSD), a magnetic tape, a cassette tape, a magnetic optical disc (MO), a mini disc (MD), an integrated circuit (IC) card (except for a memory card), an optical card, a mask ROM, or an EPROM. 
     Input device  120  is implemented, for example, by a keyboard and a mouse. A user can input various instructions to controller  110  by operating input device  120 . An image in accordance with a video signal outputted from controller  110  is shown on display device  125 . 
     Setting information for each of first analysis flow path  291 A to fourth analysis flow path  291 D (see  FIG.  1   ) provided in liquid chromatographic system  10  is shown on display device  125 . The user can set a schedule for analysis with the use of first analysis flow path  291 A to fourth analysis flow path  291 D while the user looks at a screen on display device  125 . Controller  110  conducts analysis based on the inputted schedule and has first analysis flow path  291 A to fourth analysis flow path  291 D cleaned. 
     &lt;Suction of Sample&gt; 
       FIG.  5    is a diagram exemplifying a state of suction of a sample by needle  191 . An example of suction of a sample to be injected into injection port  198 A by needle  191  from container  302 A will be described. 
     Injection port  198 A corresponds to high-pressure valve  180 A among high-pressure valves  180 A to  180 D. Therefore, first selector valve  150  and second selector valve  160  are connected to high-pressure valve  180 A. As illustrated, first selector valve  150  is connected to needle  191  with needle valve  260  and sample loop  192  being interposed. Needle moving mechanism  190  guides needle  191  to container  302 A. Second selector valve  160  is connected to metering pump  130  with low-pressure valve  170  being interposed. 
     Metering pump  130  applies a prescribed negative pressure to needle  191  with low-pressure valve  170 , second selector valve  160 , first selector valve  150 , and needle valve  260  being interposed. Needle  191  thus sucks a prescribed amount of sample from container  302 A. The sample sucked by needle  191  is held, for example, around sample loop  192 . 
       FIG.  5    shows an example in which the sample is sucked via high-pressure valve  180 A. As an object to which first selector valve  150  and second selector valve  160  are connected is switched among high-pressure valves  180 B to  180 D, the sample is sucked via corresponding one of high-pressure valves  180 B to  180 D. 
     First selector valve  150  and second selector valve  160  implement a switching device that switches a high-pressure valve through which the flow path leading from metering pump  130  to needle  191  passes, among high-pressure valves  180 A to  180 D. 
     &lt;Injection of Sample&gt; 
       FIG.  6    is a diagram exemplifying a state of injection of the sample sucked by needle  191  into injection port  198 A. 
     In injection of the sample into injection port  198 A, connection portions  187 A to  189 A are turned by thirty degrees around the center of high-pressure valve  180 A from the state shown in  FIG.  5   . High-pressure valve  180 A and high-pressure pump  220 A are connected to each other through cleaning valve  18 A. Needle moving mechanism  190  moves needle  191  to injection port  198 A. 
     Consequently, the flow path from high-pressure pump  220 A via high-pressure valve  180 A, first selector valve  150 , needle  191 , injection port  198 A, and high-pressure valve  180 A to column  230 A is formed. This flow path corresponds to the first flow path that passes through sample injection device  100  in first analysis flow path  291 A as described with reference to  FIG.  1   . At this time, column  230 A is connected to detector  500  with diverter valve  90  being interposed.  FIG.  6    does not show a state of connection between column  230 A and diverter valve  90 . The state of connection is as shown, for example, in  FIG.  3   . 
     As high-pressure pump  220 A is driven while the flow path is formed as above, the eluent is supplied to high-pressure valve  180 A. The eluent supplied to high-pressure valve  180 A flows in a direction toward needle  191  via first selector valve  150  and the like. The sample held around sample loop  192  is thus injected together with the eluent from a tip end of needle  191  into injection port  198 A. The injected sample flows to column  230 A together with the eluent. 
       FIG.  6    shows an example in which the sample is injected into injection port  198 A corresponding to high-pressure valve  180 A. As an object to which first selector valve  150  is connected is switched among high-pressure valves  180 B to  180 D, the sample is injected into corresponding one of injection ports  198 B to  198 D corresponding to respective high-pressure valves  180 B to  180 D. 
     &lt;Injection of Eluent&gt; 
       FIG.  7    is a diagram exemplifying a state of injection of an eluent into column  230 A after the sample is guided to column  230 A. 
     After the sample is guided to column  230 A, connection portions  187 A to  189 A are turned by thirty degrees around the center of high-pressure valve  180 A from the state shown in  FIG.  6   . High-pressure pump  220 A is thus connected to column  230 A through port  184 A and port  183 A of high-pressure valve  180 A. 
     This flow path corresponds to the second flow path that does not pass through sample injection device  100  in first analysis flow path  291 A as described with reference to  FIG.  1   . At this time, column  230 A is connected to detector  500  with diverter valve  90  being interposed. The state of connection is as shown, for example, in  FIG.  3   . As the eluent is supplied from high-pressure pump  220 A to high-pressure valve  180 A, the sample is separated in column  230 A. 
     At this time, injection port  198 A is connected to port  181 A which is the drain port of high-pressure valve  180 A. Furthermore, connection portions  267  to  269  of needle valve  260  are turned by thirty degrees around the center of needle valve  260  from the state shown in  FIG.  6   . Consequently, needle cleaning pump  20  is connected to needle  191  with needle valve  260  and sample loop  192  being interposed. 
       FIG.  7    shows an example in which the eluent is injected into column  230 A. As high-pressure pumps  220 B to  220 D corresponding to respective high-pressure valves  180 B to  180 D are driven, the eluent is similarly injected into respective columns  230 B to  230 D. 
     &lt;Switching of Analysis Flow Path&gt; 
       FIG.  8    is a diagram exemplifying a state of switching of a flow path to be used for analysis of a sample from first analysis flow path  291 A to second analysis flow path  291 B. The concept of first analysis flow path  291 A and second analysis flow path  291 B is as described with reference to  FIG.  1   . 
     When the flow path to be used for analysis of the sample is switched from first analysis flow path  291 A to second analysis flow path  291 B, the state of first selector valve  150  and second selector valve  160  changes. Specifically, connection portion  158  of first selector valve  150  switches an object to which port  155  is connected from port  151  to port  152 . Connection portion  168  of second selector valve  160  switches an object to which port  167  is connected from port  161  to port  162 . 
     First selector valve  150  and second selector valve  160  are thus connected to high-pressure valve  180 B. As illustrated, first selector valve  150  is connected to needle  191  with needle valve  260  and sample loop  192  being interposed. Second selector valve  160  is connected to metering pump  130  with low-pressure valve  170  being interposed. 
     For example, after needle  191  is moved to any one of containers  302 A to  302 C where the samples are accommodated, controller  110  has metering pump  130  driven. The sample can thus be sucked by needle  191  via high-pressure valve  180 B. Injection port  198 B corresponds to high-pressure valve  180 B among high-pressure valves  180 A to  180 D. Therefore, by injection of the sample sucked by needle  191  into injection port  198 B, the sample can be guided to column  230 B corresponding to second analysis flow path  291 B. 
     &lt;Construction in Comparative Example&gt; 
       FIG.  9    is a diagram showing a comparative example of liquid chromatographic system  10  according to the present embodiment. The comparative example includes a plurality of high-pressure valves  1800 A to  1800 F, a first selector valve  1500 , a second selector valve  1600 , and a low-pressure valve  1700 . 
     First selector valve  1500  and second selector valve  1600  are in coordination, and connected to any one of high-pressure valves  1800 A to  1800 F. Low-pressure valve  1700  is connected to any one of high-pressure valves  1800 A to  1800 F with second selector valve  1600  being interposed. 
     In the comparative example, a cleaning pump corresponding to each of high-pressure valves  1800 A to  1800 F is not provided, but a cleaning pump  1400  corresponding to low-pressure valve  1700  is provided. As cleaning pump  1400  is driven, the rinse solution is supplied to second selector valve  1600  via low-pressure valve  1700 . In the comparative example, as cleaning pump  1400  is driven while first selector valve  1500  and second selector valve  1600  are connected to high-pressure valve  1800 A, a flow path including high-pressure valve  1800 A can be cleaned. 
     A flow path including high-pressure valve  1800 B, however, cannot be cleaned while first selector valve  1500  and second selector valve  1600  are connected to high-pressure valve  1800 A. Similarly, flow paths including respective high-pressure valves  1800 C to  1800 F cannot be cleaned while first selector valve  1500  and second selector valve  1600  are connected to high-pressure valve  1800 A. 
     While first selector valve  1500  and second selector valve  1600  are connected to high-pressure valve  1800 A, a sample may be being analyzed through the flow path including high-pressure valve  1800 A. At this time, the flow paths including respective high-pressure valves  1800 B to  1800 F are not being used for analysis of the sample. In the comparative example, however, an object to which the rinse solution from cleaning pump  1400  is supplied is limited to an object to which second selector valve  1600  is connected. Therefore, in the comparative example, while second selector valve  1600  is connected to high-pressure valve  1800 A, flow paths including respective high-pressure valves  1800 B to  1800 F cannot be cleaned. 
     In contrast, liquid chromatographic system  10  according to the present embodiment includes cleaning pumps  143 A to  143 D corresponding to respective high-pressure valves  180 A to  180 D. Therefore, according to liquid chromatographic system  10 , the flow paths including respective high-pressure valves  180 A to  180 D can be cleaned with the rinse solution without liquid chromatographic system  10  being affected by to which of high-pressure valves  180 A to  180 D second selector valve  160  is connected. 
     &lt;Overview of First Cleaning Pattern to Fifth Cleaning Pattern&gt; 
       FIG.  10    is a diagram for illustrating overview of a first cleaning pattern to a fifth cleaning pattern. A cleaning pattern is described with reference to  FIG.  10   , with a flow path including high-pressure valve  180 A being focused on. Liquid chromatographic system  10  can clean the flow path including high-pressure valve  180 A in the first cleaning pattern to the fifth cleaning pattern shown in  FIG.  10   . 
     In the first cleaning pattern and the second cleaning pattern, the flow path including high-pressure valve  180 A is set as in an upper left frame. A solid arrow in diverter valve  90  represents a flow path set as the first cleaning pattern and a dashed arrow in diverter valve  90  represents a flow path set as the second cleaning pattern. 
     In the first cleaning pattern and the second cleaning pattern, the rinse solution supplied from cleaning pump  143 A to high-pressure valve  180 A flows sequentially through high-pressure valve  180 A, first selector valve  150 , needle valve  260 , sample loop  192 , needle  191 , high-pressure valve  180 A, column  230 A, and diverter valve  90 . 
     The flow path for cleaning set as the first cleaning pattern and the second cleaning pattern corresponds to the first flow path that passes through needle valve  260 , sample loop  192 , and needle  191 . The first flow path represents, for example, one form of first analysis flow path  291 A. 
     In the first cleaning pattern, port  91  and port  95  of diverter valve  90  are connected to each other, and hence the rinse solution that flows into diverter valve  90  flows through ports  91  and  95  and cleans the ports inclusive of the flow path leading from diverter valve  90  to detector  500 . In the second cleaning pattern, port  91  and ports  96  and  97  of diverter valve  90  are connected to each other, and hence the rinse solution that flows into diverter valve  90  cleans port  91  and is discharged from ports  96  and  97 . 
     In the third cleaning pattern and the fourth cleaning pattern, the flow path including high-pressure valve  180 A is set as shown in a lower left frame. A solid arrow in diverter valve  90  represents the flow path set as the third cleaning pattern and a dashed arrow in diverter valve  90  represents the flow path set as the fourth cleaning pattern. 
     In the third cleaning pattern and the fourth cleaning pattern, the rinse solution supplied from cleaning pump  143 A to high-pressure valve  180 A flows sequentially through high-pressure valve  180 A, column  230 A, and diverter valve  90 . 
     The flow path for cleaning set as the third cleaning pattern and the fourth cleaning pattern corresponds to the second flow path that does not pass through needle valve  260 , sample loop  192 , and needle  191 . The second flow path represents, for example, one form of first analysis flow path  291 A. 
     In the third cleaning pattern, port  91  and port  95  of diverter valve  90  are connected to each other, and hence the rinse solution that flows into diverter valve  90  flows through ports  91  and  95  and cleans the ports inclusive of the flow path leading from diverter valve  90  to detector  500 . In the fourth cleaning pattern, port  91  and ports  96  and  97  of diverter valve  90  are connected to each other, and hence the rinse solution that flows into diverter valve  90  cleans port  91  and is discharged from ports  96  and  97 . 
     In the fifth cleaning pattern, the flow path including high-pressure valve  180 A is set as shown in a right frame. In the fifth cleaning pattern, the rinse solution supplied from needle cleaning pump  20  to needle valve  260  flows sequentially through needle valve  260 , sample loop  192 , needle  191 , and high-pressure valve  180 A. The rinse solution that has flowed into high-pressure valve  180 A is discharged from port  181 A of high-pressure valve  180 A. 
     A specific construction of the first to fifth cleaning patterns will now be described. The construction of the flow path including high-pressure valve  180 A will representatively be described below. 
     &lt;First Cleaning Pattern and Second Cleaning Pattern&gt; 
       FIG.  11    is a diagram showing a specific exemplary construction of the first cleaning pattern.  FIG.  12    is a diagram showing a specific exemplary construction of the second cleaning pattern.  FIGS.  11  and  12    do not show some of features and shows features involved with diverter valve  90  as being surrounded with a frame, which is also applicable to  FIGS.  13  to  19   . 
     In the first cleaning pattern, for example, a flow path shown in  FIG.  11    is set. Specifically, port  151  and port  155  of first selector valve  150  are connected to each other. Needle  191  is connected to injection port  198 A. In high-pressure valve  180 A, port  182 A and port  183 A are connected to each other, port  184 A and port  185 A are connected to each other, and port  186 A and port  181 A are connected to each other. In diverter valve  90 , port  91  and port  95  are connected to each other. 
     As the rinse solution is supplied from cleaning pump  143 A to high-pressure valve  180 A, the flow path including high-pressure valve  180 A, first selector valve  150 , needle valve  260 , sample loop  192 , needle  191 , injection port  198 A, high-pressure valve  180 A, column  230 A, and diverter valve  90  is cleaned with the rinse solution. Furthermore, the flow path leading to detector  500  is cleaned with the rinse solution. At this time, a container for a blank sample such as the rinse solution or the eluent may be prepared at sample carrier  300 , the blank sample may be sucked by needle  191 , and cleaning in the first cleaning pattern may be performed. 
     In the second cleaning pattern, for example, a flow path shown in  FIG.  12    is set. The second cleaning pattern is different from the first cleaning pattern in setting of the flow path in diverter valve  90 . Specifically, in the second cleaning pattern, port  91  and ports  96  and  97  of diverter valve  90  are connected to each other. Therefore, in the second cleaning pattern, the flow path leading from port  91  to ports  96  and  97  of diverter valve  90  is cleaned. At this time, a container for a blank sample such as the rinse solution or the eluent may be prepared at sample carrier  300 , the blank sample may be sucked by needle  191 , and cleaning in the second cleaning pattern may be performed. 
     &lt;Third Cleaning Pattern and Fourth Cleaning Pattern&gt; 
       FIG.  13    is a diagram showing a specific exemplary construction of the third cleaning pattern.  FIG.  14    is a diagram showing a specific exemplary construction of the fourth cleaning pattern. 
     In the third cleaning pattern, for example, a flow path shown in  FIG.  13    is set. Specifically, port  181 A and port  182 A of high-pressure valve  180 A are connected to each other, port  183 A and port  184 A are connected to each other, and port  185 A and port  186 A are connected to each other. In diverter valve  90 , port  91  and port  95  are connected to each other. 
     The rinse solution supplied from cleaning pump  143 A to high-pressure valve  180 A flows to column  230 A without flowing to needle  191 . Consequently, diverter valve  90  and the flow path leading from diverter valve  90  to detector  500  are cleaned with the rinse solution. 
     In the fourth cleaning pattern, for example, a flow path shown in  FIG.  14    is set. The fourth cleaning pattern is different from the third cleaning pattern in setting of the flow path in diverter valve  90 . Specifically, in the fourth cleaning pattern, port  91  and ports  96  and  97  of diverter valve  90  are connected to each other. Therefore, in the fourth cleaning pattern, the flow path leading from port  91  to ports  96  and  97  of diverter valve  90  is cleaned. 
     &lt;Fifth Cleaning Pattern&gt; 
       FIG.  15    is a diagram showing a specific exemplary construction of the fifth cleaning pattern. 
     In the fifth cleaning pattern, for example, a flow path shown in  FIG.  15    is set. Specifically, port  262  and port  263  of needle valve  260  are connected to each other, port  264  and port  265  are connected to each other, and port  266  and port  261  are connected to each other. Port  181 A and port  182 A of high-pressure valve  180 A are connected to each other, port  183 A and port  184 A are connected to each other, and port  185 A and port  186 A are connected to each other. 
     As the rinse solution is supplied from needle cleaning pump  20  to needle valve  260 , the flow path including sample loop  192 , needle  191 , injection port  198 A, and high-pressure valve  180 A is cleaned with the rinse solution. At this time, a container for a blank sample such as the rinse solution or the eluent may be prepared at sample carrier  300 , the blank sample may be sucked by needle  191 , and cleaning in the fifth cleaning pattern may be performed. 
     As described above, according to the first cleaning pattern and the second cleaning pattern, not only the flow path from column  230 A to diverter valve  90  but also the flow path including needle  191  and sample loop  192  can be cleaned. 
     The third cleaning pattern and the fourth cleaning pattern are smaller in range of cleaning than the first cleaning pattern and the second cleaning pattern. Not including needle  191  and sample loop  192  in the third cleaning pattern and the fourth cleaning pattern, however, produces an effect of increase in variation of the cleaning method. Specifically, by making use of the third cleaning pattern and the fourth cleaning pattern, the flow path can be cleaned at timing of suction of the sample into needle  191  and sample loop  192 . 
     According to the first cleaning pattern and the third cleaning pattern, the flow path leading to detector  500 , inclusive of port  95  of diverter valve  90 , can be cleaned. Such a cleaning pattern is effective, for example, in an example in which a sample at a high concentration is analyzed or in a construction in which analysis can continue with switching among a plurality of analysis flow paths (first analysis flow path  291 A to fourth analysis flow path  291 D) being made as in liquid chromatographic system  10  according to the present embodiment. 
     When analysis continues with switching among a plurality of analysis flow paths being made, a component in the sample may be accumulated in diverter valve  90  that switches among the analysis flow paths. In particular, the component in the sample may repeatedly be accumulated at port  95  in diverter valve  90  to which detector  500  is connected and carryover may occur. Alternatively, since the sample is continuously sent to an interface portion of detector  500  through diverter valve  90 , carryover may occur in that interface portion. 
     According to the first cleaning pattern and the third cleaning pattern, port  95  of diverter valve  90 , inclusive of the interface portion of detector  500 , can be cleaned. Therefore, while efficient analysis through a plurality of analysis flow paths is conducted, a portion which will be a factor for occurrence of carryover can sufficiently be cleaned. 
     An example in which the flow path is cleaned with the rinse solution is described with reference to  FIGS.  10  to  15   . In the first to fifth cleaning patterns, however, the flow path may be cleaned with the eluent (blank solution). For example, with the use of high-pressure pump  220 A instead of cleaning pump  143 A in the first to fourth cleaning patterns, cleaning with the eluent may be performed. In the fifth cleaning pattern, by connection of needle cleaning pump  20  to the container where the eluent is accommodated, cleaning with the eluent may be performed. Furthermore, in the first to fifth cleaning patterns, cleaning with the rinse solution and the eluent as being combined may be performed. For example, after the flow path is cleaned with the rinse solution, the flow path may be cleaned with the eluent. 
     The first to fifth cleaning patterns are described with reference to the example in which the flow path includes high-pressure valve  180 A. In liquid chromatographic system  10 , however, the flow paths including respective high-pressure valves  180 B to  180 D can naturally be cleaned similarly in the first to fifth cleaning patterns. The description above is similarly applicable also to the flow paths including respective high-pressure valves  180 B to  180 D. 
     An example in which the flow path defined in liquid chromatographic system  10  is cleaned in various cleaning patterns while a sample is being analyzed or preparation for analysis is being made in one of first analysis flow path  291 A to fourth analysis flow path  291 D will now be described with reference to  FIGS.  16  to  19   . 
     &lt;Example of Cleaning During Suction of Sample&gt; 
       FIG.  16    is a diagram showing an example in which a flow path is cleaned in the third cleaning pattern and the fourth cleaning pattern during suction of the sample. In particular, an example in which, during suction of the sample, first analysis flow path  291 A is cleaned in the third cleaning pattern and second analysis flow path  291 B is cleaned in the fourth cleaning pattern will be described. 
     In  FIG.  16   , first selector valve  150  and second selector valve  160  are connected to high-pressure valve  180 A. In diverter valve  90 , port  91  leading to column  230 A and port  95  leading to detector  500  are connected to each other. Therefore, the sample is ready for analysis through first analysis flow path  291 A including high-pressure valve  180 A. 
     Metering pump  130  is connected to needle  191  with low-pressure valve  170 , second selector valve  160 , high-pressure valve  180 A, first selector valve  150 , and needle valve  260  being interposed. Needle  191  is guided to container  302 A where the sample is accommodated. Needle  191  sucks the sample from container  302 A by application of a negative pressure by metering pump  130 . 
     In high-pressure valve  180 B, port  183 B and port  184 B are connected to each other. 
     In such a state, liquid chromatographic system  10  can perform cleaning in the third cleaning pattern targeted for first analysis flow path  291 A including high-pressure valve  180 A and cleaning in the fourth cleaning pattern targeted for second analysis flow path  291 B including high-pressure valve  180 B. 
     The rinse solution supplied from cleaning pump  143 A to high-pressure valve  180 A flows through high-pressure valve  180 A, column  230 A, and diverter valve  90 , and cleans those portions and the flow path leading to detector  500  (third cleaning pattern). 
     The rinse solution supplied from cleaning pump  143 B to high-pressure valve  180 B flows through high-pressure valve  180 B, column  230 B, and diverter valve  90 , and cleans the flow path including those portions (fourth cleaning pattern). 
     Liquid chromatographic system  10  can thus clean first analysis flow path  291 A while an operation to suction the sample continues for analysis of the sample through first analysis flow path  291 A. Furthermore, liquid chromatographic system  10  can clean second analysis flow path  291 B. Liquid chromatographic system  10  can naturally clean third analysis flow path  291 C including high-pressure valve  180 C and fourth analysis flow path  291 D including high-pressure valve  180 D together. 
     &lt;Example of Cleaning During Injection of Sample&gt; 
       FIG.  17    is a diagram showing an example in which the flow path is cleaned in the fourth cleaning pattern during injection of the sample. In particular, an example in which second analysis flow path  291 B is cleaned in the fourth cleaning pattern while the sample is injected into column  230 A in first analysis flow path  291 A will be described. 
     In  FIG.  17   , first selector valve  150  and second selector valve  160  are connected to high-pressure valve  180 A. In diverter valve  90 , port  91  leading to column  230 A and port  95  leading to detector  500  are connected to each other. 
     High-pressure pump  220 A is connected to needle  191  with high-pressure valve  180 A, first selector valve  150 , and needle valve  260  being interposed. Needle  191  is connected to injection port  198 A. The sample is held in sample loop  192 . Needle  191  injects the sample in sample loop  192  into injection port  198 A, together with the eluent supplied from high-pressure pump  220 A. The sample is thus injected into column  230 A through high-pressure valve  180 A. 
     In high-pressure valve  180 B, port  183 B and port  184 B are connected to each other. 
     In such a state, liquid chromatographic system  10  can perform cleaning in the fourth cleaning pattern targeted for second analysis flow path  291 B including high-pressure valve  180 B. Specifically, by supply of the rinse solution from cleaning pump  143 B to high-pressure valve  180 B, the flow path including high-pressure valve  180 B, column  230 B, and diverter valve  90  can be cleaned (fourth cleaning pattern). 
     Thus, liquid chromatographic system  10  can clean second analysis flow path  291 B while an operation to inject the sample into column  230 A in first analysis flow path  291 A continues. Liquid chromatographic system  10  can naturally clean third analysis flow path  291 C including high-pressure valve  180 C and fourth analysis flow path  291 D including high-pressure valve  180 D together. 
     &lt;First Example of Cleaning During Analysis of Sample&gt; 
       FIG.  18    is a diagram showing an example in which the flow path is cleaned in the second cleaning pattern during analysis of the sample. In particular, an example in which second analysis flow path  291 B is cleaned in the second cleaning pattern while the sample is being analyzed through first analysis flow path  291 A will be described. 
     In  FIG.  18   , high-pressure pump  220 A is connected to column  230 A via high-pressure valve  180 A. The sample is accommodated in column  230 A. In diverter valve  90 , port  91  leading to column  230 A and port  95  leading to detector  500  are connected to each other. The eluent supplied from high-pressure pump  220 A is injected through high-pressure valve  180 A into column  230 A where the sample is accommodated. In detector  500 , analysis of the sample proceeds. 
     First selector valve  150  and second selector valve  160  are connected to high-pressure valve  180 B. Cleaning pump  143 B is connected to needle  191  with high-pressure valve  180 B, first selector valve  150 , and needle valve  260  being interposed. Needle  191  is guided to injection port  198 B. 
     In such a state, liquid chromatographic system  10  can perform cleaning in the second cleaning pattern targeted for second analysis flow path  291 B including high-pressure valve  180 B. Specifically, by supply of the rinse solution from cleaning pump  143 B to high-pressure valve  180 B, the rinse solution flows sequentially through high-pressure valve  180 B, first selector valve  150 , needle valve  260 , sample loop  192 , needle  191 , injection port  198 B, high-pressure valve  180 B, column  230 B, and diverter valve  90 , and the flow path including those portions is cleaned (second cleaning pattern). 
     Thus, liquid chromatographic system  10  can clean second analysis flow path  291 B in the second cleaning pattern while analysis of the sample proceeds in first analysis flow path  291 A. Liquid chromatographic system  10  can naturally clean, instead of second analysis flow path  291 B, third analysis flow path  291 C including high-pressure valve  180 C or fourth analysis flow path  291 D including high-pressure valve  180 D in the second cleaning pattern. 
     Liquid chromatographic system  10  can also clean second analysis flow path  291 B in the fourth pattern while analysis of the sample proceeds in first analysis flow path  291 A. Furthermore, while analysis of the sample proceeds in first analysis flow path  291 A, liquid chromatographic system  10  can clean second analysis flow path  291 B in the second cleaning pattern and also third analysis flow path  291 C in the fourth cleaning pattern. 
     &lt;Second Example of Cleaning During Analysis of Sample&gt; 
       FIG.  19    is a diagram showing an example in which the flow path is cleaned in the fourth cleaning pattern and the fifth cleaning pattern during analysis of the sample. In particular, an example in which second analysis flow path  291 B is cleaned in the fourth cleaning pattern and the flow path including high-pressure valve  180 A is cleaned in the fifth cleaning pattern while the sample is being analyzed through first analysis flow path  291 A will be described. 
     In  FIG.  19   , first selector valve  150  and second selector valve  160  are connected to high-pressure valve  180 A. In diverter valve  90 , port  91  leading to column  230 A and port  95  leading to detector  500  are connected to each other. The eluent supplied from high-pressure pump  220 A is injected through high-pressure valve  180 A into column  230 A where the sample is accommodated. In detector  500 , analysis of the sample proceeds. 
     In needle valve  260 , port  262  and port  263  are connected to each other. In high-pressure valve  180 B, port  183 B and port  184 B are connected to each other. 
     In such a state, liquid chromatographic system  10  can perform cleaning in the fifth cleaning pattern targeted for the flow path including high-pressure valve  180 A and cleaning in the fourth cleaning pattern targeted for second analysis flow path  291 B including high-pressure valve  180 B. 
     The rinse solution supplied from needle cleaning pump  20  to needle valve  260  flows through needle valve  260 , sample loop  192 , needle  191 , and high-pressure valve  180 A and the flow path including those portions is cleaned (fifth cleaning pattern). 
     The rinse solution supplied from cleaning pump  143 B to high-pressure valve  180 B flows through high-pressure valve  180 B, column  230 B, and diverter valve  90  and the flow path including those portions is cleaned (fourth cleaning pattern). 
     Thus, liquid chromatographic system  10  can perform cleaning in the fifth cleaning pattern targeted for the flow path including high-pressure valve  180 A and cleaning in the fourth cleaning pattern targeted for second analysis flow path  291 B including high-pressure valve  180 B while processing for analyzing the sample through first analysis flow path  291 A continues. 
     Liquid chromatographic system  10  can naturally clean third analysis flow path  291 C including high-pressure valve  180 C and fourth analysis flow path  291 D including high-pressure valve  180 D together in the fourth cleaning pattern. 
     &lt;Types of Selectable Cleaning Patterns&gt; 
       FIG.  20    is a diagram showing a cleaning pattern that can be selected for first analysis flow path  291 A to fourth analysis flow path  291 D.  FIG.  20    shows, for each of first analysis flow path  291 A to fourth analysis flow path  291 D, types of selectable cleaning patterns in each stage of three processes that proceed with the use of first analysis flow path  291 A. 
     Various cleaning patterns described so far with reference to  FIGS.  10  to  19    are summarized. For example, while first analysis flow path  291 A is being used for analysis of the sample, types of selectable cleaning patterns for cleaning of first analysis flow path  291 A to fourth analysis flow path  291 D are as shown in  FIG.  20   . 
     The flow path cleaned in the fifth cleaning pattern is the flow path through which the cleaning solution flows toward ports  181 A to  184 A which are drain ports of high-pressure valves  180 A to  180 D.  FIG.  20    shows the fifth cleaning pattern in correspondence with first analysis flow path  291 A to fourth analysis flow path  291 D, as the cleaning pattern relating to first analysis flow path  291 A to fourth analysis flow path  291 D. 
     Stages of sample suction, sample injection, and eluent injection shown in  FIG.  20    mean a stage of suction of the sample by needle  191 , a stage of injection of the sucked sample from needle  191  via injection port  198 A and high-pressure valve  180 A into column  230 A, and a stage of injection of the eluent supplied from high-pressure pump  220 A to high-pressure valve  180 A into column  230 A, respectively. 
     While the sample is being sucked by needle  191 , first analysis flow path  291 A to fourth analysis flow path  291 D can be cleaned in the third or fourth cleaning pattern. For example, first analysis flow path  291 A can be cleaned in the third cleaning pattern and second analysis flow path  291 B to fourth analysis flow path  291 D can be cleaned in the third cleaning pattern. 
     While the sucked sample is being injected from needle  191  via injection port  198 A and high-pressure valve  180 A into column  230 A, second analysis flow path  291 B to fourth analysis flow path  291 D can be cleaned in the third or fourth cleaning pattern. For example, second analysis flow path  291 B can be cleaned in the third cleaning pattern and third analysis flow path  291 C and fourth analysis flow path  291 D can be cleaned in the fourth cleaning pattern. 
     While the eluent supplied from high-pressure pump  220 A to high-pressure valve  180 A is being injected into column  230 A, first analysis flow path  291 A can be cleaned in the fifth cleaning pattern. A portion cleaned at this time includes the needle valve, sample loop  192 , needle  191 , injection port  198 A, port  182 A of high-pressure valve  180 A, and port  181 A of high-pressure valve  180 A. 
     While the eluent supplied from high-pressure pump  220 A to high-pressure valve  180 A is being injected into column  230 A, second analysis flow path  291 B to fourth analysis flow path  291 D can be cleaned in any one of the second, fourth, and fifth cleaning patterns. For example, second analysis flow path  291 B can be cleaned in the second cleaning pattern and third analysis flow path  291 C and fourth analysis flow path  291 D can be cleaned in the fourth cleaning pattern. 
     Liquid chromatographic system  10  can thus clean first analysis flow path  291 A to fourth analysis flow path  291 D in various cleaning patterns. Liquid chromatographic system  10  accepts input of the cleaning pattern to be used for cleaning of each analysis flow path and timing of cleaning. 
     A user sets the cleaning pattern to be used for cleaning of each analysis flow path and timing of cleaning, with the use of input device  120  (see  FIG.  4   ). Contents of setting are shown on display device  125  (see  FIG.  4   ). Controller  110  (see  FIG.  4   ) sets the cleaning pattern to be used for cleaning of each analysis flow path and timing of cleaning in accordance with an instruction from the user provided to input device  120 . 
     &lt;Exemplary Setting for Cleaning Pattern&gt; 
       FIG.  21    is a timing chart showing exemplary setting for the cleaning pattern. In  FIGS.  21   , ( 1 ) to ( 5 ) mean the first to fifth cleaning patterns, respectively. A flow of processing performed by liquid chromatographic system  10  in accordance with the cleaning pattern and the timing of cleaning set in accordance with an instruction from the user will be described with reference to  FIG.  21   . 
     Analysis of the sample is conducted with successive use of first analysis flow path  291 A to fourth analysis flow path  291 D. Initially, first analysis flow path  291 A is cleaned in the first cleaning pattern. Thus, the flow path including high-pressure valve  180 A, first selector valve  150 , needle valve  260 , sample loop  192 , needle  191 , injection port  198 A, high-pressure valve  180 A, column  230 A, and diverter valve  90  is cleaned with the rinse solution. Furthermore, the flow path leading from diverter valve  90  to detector  500  is cleaned with the rinse solution. 
     Then, the sample is sucked by needle  191  in first analysis flow path  291 A. While the sample is sucked by needle  191 , second analysis flow path  291 B to fourth analysis flow path  291 D are cleaned in the fourth cleaning pattern. Thus, for example, in second analysis flow path  291 B, the flow path leading from high-pressure valve  180 B to column  230 B and the flow path leading from column  230 B to ports  96  and  97  of diverter valve  90  are cleaned. 
     As suction of the sample in first analysis flow path  291 A ends, processing for injecting the sample together with eluent into column  230 A is performed. As all the sample is injected from needle  191 , cleaning in the fifth cleaning pattern is performed. The flow path including needle valve  260 , sample loop  192 , needle  191 , injection port  198 A, and high-pressure valve  180 A is thus cleaned. 
     As all the sample is injected from needle  191  in first analysis flow path  291 A, the state of connection of high-pressure valve  180 A is switched and processing for feeding the eluent to the sample injected into column  230 A is started. Analysis thus proceeds in detector  500 . 
     While analysis proceeds in first analysis flow path  291 A, cleaning in the second cleaning pattern is performed in the order of second analysis flow path  291 B to fourth analysis flow path  291 D. When analysis ends in first analysis flow path  291 A, first analysis flow path  291 A is cleaned in the second cleaning pattern and in the third cleaning pattern. 
     Then, processing for analyzing the sample through second analysis flow path  291 B is started. Specifically, an object to which first selector valve  150  and second selector valve  160  are connected is switched from high-pressure valve  180 A to high-pressure valve  180 B. In succession, second analysis flow path  291 B is cleaned in the first cleaning pattern. 
     Hereafter, as shown in  FIG.  21   , in a similar procedure, processing for analyzing the sample through second analysis flow path  291 B to fourth analysis flow path  291 D and processing for cleaning first analysis flow path  291 A to fourth analysis flow path  291 D are repeated. 
     &lt;Cleaning With Rinse Solution and Eluent as Being Combined&gt; 
       FIG.  22    is a timing chart showing an exemplary pattern of driving cleaning pumps  143 A to  143 D and high-pressure pumps  220 A to  220 D. Liquid chromatographic system  10  can use the rinse solution and the eluent (blank solution) as the cleaning solution in cleaning of the flow path in the first to fourth cleaning patterns. 
     For example, in cleaning of first analysis flow path  291 A, initially, cleaning pump  143 A is driven. The first analysis flow path is thus cleaned with the rinse solution. At a time point of lapse of time T 1  since drive of cleaning pump  143 A, high-pressure pump  220 A instead of cleaning pump  143 A is driven. The first analysis flow path is thus cleaned with the eluent. At a time point of lapse of time T 2  since drive of high-pressure pump  220 A, drive of high-pressure pump  220 A is stopped. 
     According to such a drive pattern, after cleaning with the rinse solution, the eluent flows. Therefore, the mobile phase composed of the eluent can be in equilibrium in columns  230 A to  230 D. Such a drive pattern may be adopted in all of the first to fourth cleaning patterns. For example, in setting for the cleaning pattern shown in  FIG.  21   , the rinse solution and the eluent as shown in  FIG.  22    may be combined with each other. 
     Though drive of high-pressure pump  220 A is stopped at the time point of lapse of time T 2  since drive of high-pressure pump  220 A, drive of high-pressure pump  220 A does not have to be stopped but high-pressure pump  220 A may constantly be driven except for when the rinse solution is supplied from cleaning pump  143 A. 
     &lt;Flow of Processing (Setting)&gt; 
       FIG.  23    is a flowchart of processing for accepting an input for setting relating to analysis from a user in liquid chromatographic system  10 . In one implementation, the processing shown in  FIG.  23    is performed by execution of a given program by processor  111 . 
     In step S 100 , liquid chromatographic system  10  has a setting screen displayed on display device  125 . The setting screen accepts an input of information (for example, a name of a compound) that specifies an object to be analyzed.  FIG.  24    shows an exemplary setting screen. As shown in  FIG.  24   , a setting screen  2400  includes an input field  2401  where an input of an object to be analyzed and specifying information are accepted. 
     Referring back to  FIG.  23   , in step S 102 , liquid chromatographic system  10  obtains information specifying the object to be analyzed that has been inputted in the setting screen, and writes the information in memory  112 . Thereafter, liquid chromatographic system  10  quits the process in  FIG.  23   . 
     &lt;Method File Database&gt; 
       FIG.  25    is a diagram schematically showing an exemplary data configuration in a method file database. The method file database includes two or more cleaning method files (method file below). Each method file defines contents of analysis and cleaning by liquid chromatographic system  10 . 
     More specifically,  FIG.  25    shows four types of method files ( 1 ) to ( 4 ). Each of method files ( 1 ) to ( 4 ) includes an analysis method and a cleaning method. In other words, in the method file database, each of one or more analysis methods (analysis conditions) is combined with any one of one or more cleaning methods. 
     In the example in  FIG.  25   , the analysis method included in method file ( 1 ) includes a value R 1  as a setting value of a flow rate of the eluent. According to method file ( 1 ), liquid chromatographic system  10  controls the high-pressure pump (high-pressure pump  220 A or the like) such that the eluent is delivered at a flow rate R 1  to the column (column  230 A or the like) in analysis. 
     The cleaning method included in method file ( 1 ) includes a setting value of each of an “execution condition,” “a target sample,” and a “cleaning content.” 
     The “execution condition” means a condition for selection of each method file. In method file ( 1 ), the setting value of the “execution condition” includes “QC value≥V 1 .” The QC value means a result of analysis for quality control of a stream and represents a remaining amount of a compound in the stream. A larger QC value means a larger remaining amount. A specific example of a method of calculating a QC value will be described later with reference to step S 208  in  FIG.  26   . The setting value of the execution condition being “QC value≥V 1 ” means that method file ( 1 ) is selected when a value of this result of analysis is equal to or larger than V 1 . 
     The “target sample” means an object to be analyzed in liquid chromatographic system  10 . In one implementation, in step SiO 2 , liquid chromatographic system  10  specifies an object to be analyzed (target sample) based on information inputted into the setting screen. 
     In method file ( 1 ), the setting value of the “target sample” includes “K 1 ”. The setting value of the target sample being “K 1 ” means selection of method file ( 1 ) when the target sample is “K 1 ”. 
     The “cleaning content” means contents performed in cleaning of the stream. In method file ( 1 ), the value of the “cleaning content” includes “1st cleaning pattern [10 min]” and “2nd cleaning pattern [10 min],” which means that, for cleaning of the stream, cleaning for ten minutes is performed in the first cleaning pattern ( FIG.  11   ) and thereafter cleaning for ten minutes is performed in the second cleaning pattern ( FIG.  12   ). 
     Method file ( 2 ) is different from method file ( 1 ) in setting value of each of the execution condition and the cleaning content. In method file ( 2 ), the setting value of the “execution condition” includes “QC value&lt;V 1 ”. 
     In method file ( 2 ), the value of the “cleaning content” includes “1st cleaning pattern [5 min]” and “2nd cleaning pattern [5 min],” which means that, for cleaning of the stream, cleaning for five minutes is performed in the first cleaning pattern ( FIG.  11   ) and thereafter cleaning for five minutes is performed in the second cleaning pattern ( FIG.  12   ). 
     In the example in  FIG.  25   , when the target sample is “K 1 ” and the condition of QC value≥V 1  is satisfied, method file ( 1 ) is selected. When the target sample is “K 1 ” and the condition of QC value&lt;V 1  is satisfied, method file ( 2 ) is selected. Method file ( 1 ) is longer than method file ( 2 ) in time period for which each of the first cleaning pattern and the second cleaning pattern is performed. The QC value represents magnitude of a remaining amount of a compound in the stream. In other words, in the present embodiment, as the remaining amount of the compound in the stream is larger, the cleaning method longer in time period for cleaning is selected. 
     Method file ( 3 ) is different from method file ( 1 ) in setting value of each of the target sample and the cleaning content. In method file ( 3 ), the setting value of the “target sample” includes “other than K 1 .” 
     In method file ( 3 ), the value of the “cleaning content” includes “1st cleaning pattern [9 min]” and “second cleaning pattern [9 min],” which means that, for cleaning of the stream, cleaning for nine minutes is performed in the first cleaning pattern ( FIG.  11   ) and thereafter cleaning for nine minutes is performed in the second cleaning pattern ( FIG.  12   ). 
     In the example in  FIG.  25   , when the target sample is “K 1 ” and the condition of QC value V 1  is satisfied, method file ( 1 ) is selected. When the target sample is “other than K 1 ” and the condition of QC value≥V 1  is satisfied, method file ( 3 ) is selected. 
     Method file ( 4 ) is different from method file ( 2 ) in setting value of each of the target sample and the cleaning content. In method file ( 4 ), the setting value of the “target sample” includes “other than K 1 .” 
     In method file ( 4 ), the value of the “cleaning content” includes “1st cleaning pattern [4 min]” and “second cleaning pattern [4 min],” which means that, for cleaning of the stream, cleaning for four minutes is performed in the first cleaning pattern ( FIG.  11   ) and thereafter cleaning for four minutes is performed in the second cleaning pattern ( FIG.  12   ). 
     In the example in  FIG.  25   , when the target sample is “K 1 ” and the condition of QC value&lt;V 1  is satisfied, method file ( 2 ) is selected. When the target sample is “other than K 1 ” and the condition of QC value&lt;V 1  is satisfied, method file ( 4 ) is selected. 
     &lt;Flow of Processing (Analysis)&gt; 
       FIG.  26    is a flowchart of processing for analyzing a sample in liquid chromatographic system  10 . In one implementation, the processing shown in  FIG.  26    is performed by execution of a given program by processor  111 . 
     In step S 200 , liquid chromatographic system  10  sets “1” as a value of a variable N to be used in the processing in  FIG.  26   . Variable N identifies a stream to be used for analysis among four streams. When the value of variable N is set to “1”, the first stream (first analysis flow path  291 A) is used for analysis. When the value of variable N is set to “2”, the second stream (second analysis flow path  291 B) is used for analysis. When the value of variable N is set to “3”, the third stream (third analysis flow path  291 C) is used for analysis. When the value of variable N is set to “4”, the fourth stream (fourth analysis flow path  291 D) is used for analysis. 
     In step S 202 , liquid chromatographic system  10  has the high-pressure pump (any one of high-pressure pumps  220 A to  220 D) in the stream deliver the eluent to the stream to be used for analysis to inject the eluent toward detector  500 . Control in step S 202  corresponds to what is called “blank injection.” 
     In step S 204 , liquid chromatographic system  10  instructs detector  500  to perform analysis. In response, detector  500  analyzes the eluent injected by “blank injection.”In step S 206 , liquid chromatographic system  10  obtains from detector  500 , results of analysis of the eluent injected by “blank injection.” 
     In step S 208 , liquid chromatographic system  10  calculates the QC value from the results of analysis obtained in step S 206 . In one implementation, liquid chromatographic system  10  obtains mass spectrum (MS) data as the results of analysis and then calculates the QC value as a height of a peak other than peaks originating from the eluent in the MS data. 
     In step S 210 , liquid chromatographic system  10  reads the target sample obtained in step S 102  from memory  112 . 
     In step S 212 , liquid chromatographic system  10  specifies a method file to be referred to in present analysis among a plurality of method files included in the method file database, based on the QC value calculated in step S 208  and the target sample read in step S 210 . In other words, the QC value calculated in step S 208  satisfies a cleaning method “execution condition” in the specified method file. The target sample read in step S 210  is included in the “target sample” in the cleaning method in the specified method file. 
     In step S 214 , liquid chromatographic system  10  cleans the stream in accordance with the cleaning method in the method file specified in step S 212 . 
     In step S 216 , liquid chromatographic system  10  starts display of stream information on display device  125 .  FIG.  27    is a diagram showing an exemplary screen on which stream information is shown. 
     A screen  2600  in  FIG.  27    includes a graph  2601 . Graph  2601  shows change over time of high-pressure pump  220 A in the first stream and high-pressure pump  220 B in the second stream. The left ordinate of graph  2601  represents a pressure value. The abscissa of graph  2601  represents time. 
     The example in  FIG.  27    shows the pressure value of the high-pressure pump in each of the first stream and the second stream. The pressure value of the high-pressure pump means a pressure at which the high-pressure pump delivers a liquid. 
     So long as the stream information includes a pressure value of a high-pressure pump in a stream used for analysis, the stream information may include pressure values of high-pressure pumps in all streams or may include only a pressure value of a high-pressure pump in at least one stream. Furthermore, a QC value calculated for each stream may be shown as the stream information. In one implementation, liquid chromatographic system  10  continuously detects the pressure value of the high-pressure pump and continues display of the stream information until the analysis method which will be described later as step S 218  ends. 
     Referring again to  FIG.  26   , in step S 218 , liquid chromatographic system  10  analyzes the sample in accordance with the analysis method in the method file specified in step S 212 . 
     In step S 220 , liquid chromatographic system  10  updates the value of variable N. More specifically, when the value of variable N has been set to one of “1” to “3”, in step S 220 , liquid chromatographic system  10  updates the value of variable N to increase by one. When the value of variable N has been set to “4”, the liquid chromatographic system updates the value of variable N to “1”. The value of variable N thus circulates among “1” to “4”. Thereafter, liquid chromatographic system  10  has control return to step S 202 . 
     According to the processing described above, liquid chromatographic system  10  obtains results of analysis for quality control of each stream at the time of start of analysis with the use of the stream. Then, liquid chromatographic system  10  specifies a method file to be used for analysis based on the results of analysis for quality control. As the method file is specified, a cleaning method for analysis is specified. The cleaning method defines a mode of cleaning to define a method with which one or more pumps are controlled in cleaning. The one or more pumps include at least one of high-pressure pumps  220 A to  220 D and cleaning pumps  143 A to  143 D. As the cleaning method for each stream is specified as above, each stream is cleaned in accordance with a state of each stream. Therefore, according to the present disclosure, a technique for appropriately cleaning each stream is provided. 
     In liquid chromatographic system  10 , a plurality of types of cleaning solutions may be connected to a single pump for cleaning. In the method file database, the cleaning method may define a type of the cleaning solution to be used for cleaning. Liquid chromatographic system  10  specifies a single cleaning method file in step S 212  to thereby specify a single cleaning method. As a single cleaning method is specified, the type of the cleaning solution to be used for cleaning is specified. In step S 214 , liquid chromatographic system  10  may control a manner of connection in liquid chromatographic system  10  such that only a cleaning solution of a type specified to be used for cleaning among the plurality of types of cleaning solutions is connected to the pump for cleaning. 
     The QC value obtained as results of analysis for quality control is not limited to the value based on MS data. Results of analysis in accordance with an analysis method other than mass spectrometry may be used for calculation of the results of analysis. For example, a liquid chromatogram of a sample that has been subjected to “blank injection” may be used. In this case, the QC value may be calculated from the liquid chromatogram based on a peak value of a peak originating from a compound other than the eluent. 
     The mode of cleaning includes which of the first to fifth cleaning patterns is selected and/or a length of time for which the cleaning pattern is performed. Each of high-pressure pumps  220 A to  220 D represents an exemplary drive pump that supplies a mobile phase to a stream. 
     In liquid chromatographic system  10 , four streams (first analysis flow path  291 A, second analysis flow path  291 B, third analysis flow path  291 C, and fourth analysis flow path  291 D) are arranged in parallel. When liquid chromatographic system  10  performs cleaning of one stream in accordance with the cleaning method in step S 214 , it may perform cleaning of another stream with the same cleaning method. Control in liquid chromatographic system  10  including a plurality of streams can thus be facilitated. 
     After liquid chromatographic system  10  performs the analysis method in step S 218 , it may perform the cleaning method included in the cleaning method file the same as the cleaning method file including the analysis method in the method file database. In other words, after analysis in accordance with one analysis condition, liquid chromatographic system  10  may have the pump for cleaning driven in accordance with a cleaning method combined with the analysis method in the method file database. 
     When a sample is being injected into another stream at the time when an attempt at cleaning of another stream in accordance with the cleaning method is made in step S 214 , liquid chromatographic system  10  may perform cleaning of another stream after end of injection of the sample. 
     Furthermore, in liquid chromatographic system  10 , only a target sample may be used for specifying a method file. Specifically, in the example in  FIG.  26   , in step S 212 , a method file to be referred to in present analysis is specified based on both of the QC value calculated in step S 208  and the target sample read in step S 210 . The method file to be referred to in present analysis, however, may be specified based only on the QC value calculated in step S 208  or only on the target sample read in step S 210 . 
       FIG.  28    is a diagram showing a first modification of the method file database. In the method file database shown in  FIG.  28   , no target sample is associated with the cleaning method. In this example, in step S 212 , liquid chromatographic system  10  specifies as the method file to be referred to in analysis, a method file including the QC value calculated in step S 208  as the execution condition. 
       FIG.  29    is a diagram showing a second modification of the method file database. The method file database shown in  FIG.  29    includes the target sample as the cleaning method execution condition. In this example, in step S 212 , liquid chromatographic system  10  specifies as the method file to be referred to in analysis, a method file including the target sample read in step S 210  as the execution condition. In this example, the “target sample” is exemplary information that specifies a sample to be analyzed in the stream used for analysis. 
     [Aspects] 
     Illustrative embodiments described above are understood by a person skilled in the art as specific examples of aspects below. 
     (Clause 1) A liquid chromatographic system according to one aspect includes a first column that separates a sample for each component, a first stream which is an analysis flow path including the first column, one or more cleaning pumps that supply a cleaning solution to the first stream, a memory in which two or more combinations of a cleaning method and a cleaning execution condition are stored, and a processor. The processor may be configured to analyze a sample through the first stream and obtain at least one of a result of analysis for quality control of the first stream and information that specifies a sample to be analyzed in the first stream, specify a first combination including an execution condition to which at least one of the result of analysis for quality control and the information corresponds, among the two or more combinations, and drive the one or more cleaning pumps in accordance with the cleaning method included in the first combination. 
     According to the liquid chromatographic system described in Clause 1, the stream is appropriately cleaned. 
     (Clause 2) In the liquid chromatographic system described in Clause 1, the processor may obtain the result of analysis for quality control, and the result of analysis for quality control may include a result of analysis of a remaining amount of a component that has passed through the first stream. 
     According to the liquid chromatographic system described in Clause 2, contamination accumulated in the first stream together with an eluent used as a mobile phase is reflected on the result of analysis for quality control. 
     (Clause 3) In the liquid chromatographic system described in claim  2 , the result of analysis for quality control may include a result of analysis by a mass spectrometry device. 
     According to the liquid chromatographic system described in Clause 3, a result of mass spectrometry of contamination accumulated in the first stream can be obtained. 
     (Clause 4) In the liquid chromatographic system described in any one of claims  1  to  3 , the one or more cleaning pumps may include a drive pump that supplies a mobile phase to the first stream, and the processor may have change over time of a pressure of delivery by the drive pump and the result of analysis for quality control shown. 
     According to the liquid chromatographic system described in Clause 4, a user can visually recognize the drive pump and the result of analysis for quality control. 
     (Clause 5) The liquid chromatographic system described in any one of claims  1  to  4  may further include an input device that accepts input of the information. 
     According to the liquid chromatographic system described in Clause 5, as the user inputs a type of a sample to be analyzed next, a method of cleaning the stream can be set in accordance with the type of the sample. 
     (Clause 6) The liquid chromatographic system described in any one of claims  1  to  5  may further include a second stream provided in parallel to the first stream. In the liquid chromatographic system, the processor may carry out control for cleaning in accordance with the first combination for the second stream in response to specifying of the first combination for the first stream. 
     According to the liquid chromatographic system described in Clause 6, control in the liquid chromatographic system including a plurality of streams can be facilitated. 
     (Clause 7) In the liquid chromatographic system described in claim  6 , the processor may have the second stream cleaned with a method identical to the cleaning method for the first combination in response to specifying of the first combination for the first stream. 
     According to the liquid chromatographic system described in Clause 7, the plurality of streams can be cleaned with the same method. 
     (Clause 8) In the liquid chromatographic system described in claim  6 , when a sample is injected into the second stream, after this injection, the processor may carry out control for cleaning in accordance with the first combination for the second stream. 
     According to the liquid chromatographic system described in Clause 8, waste due to cleaning, of the sample being injected into the second stream is avoided. 
     (Clause 9) In the liquid chromatographic system described in any one of claims  1  to  8 , in the two or more combinations, the execution condition may be combined with the method longer in time period for cleaning as a remaining amount of a compound is larger in the first stream indicated in a corresponding result of analysis for quality control. 
     According to the liquid chromatographic system described in Clause 9, even when a remaining amount of a compound in the first stream is large, the compound can reliably be removed by cleaning. 
     (Clause 10) A liquid chromatographic system according to another aspect includes a first stream including an analysis flow path, one or more cleaning pumps that supply a cleaning solution to the first stream, a processor, and a memory in which one or more analysis conditions and one or more cleaning methods are stored. In the memory, each of the one or more analysis conditions may be combined with any one of the one or more cleaning methods. The processor may determine to use the first stream for analysis of a sample, and after analysis in accordance with any one analysis condition of the one or more analysis conditions, the processor may have the one or more cleaning pumps driven in accordance with one cleaning method combined with the one analysis condition among the one or more cleaning methods. 
     According to the liquid chromatographic system described in Clause 10, the stream is appropriately cleaned. 
     (Clause 11) In the liquid chromatographic system described in any one of claims  1  to  10 , a plurality of cleaning solutions may be connected to at least one of the one or more cleaning pumps, and the processor may select one cleaning solution of the plurality of cleaning solutions in accordance with the cleaning method, and have the selected cleaning solution connected to the one or more cleaning pumps. 
     According to the liquid chromatographic system described in Clause  11 , the stream is cleaned with a cleaning solution appropriate for a cleaning method to be performed. 
     (Clause 12) A cleaning method according to one aspect is a method of cleaning a liquid chromatographic system. The liquid chromatographic system includes a first stream including an analysis flow path including a first analysis column, one or more pumps that supply a liquid to the first stream, and a memory in which two or more combinations of a cleaning method and a cleaning execution condition are stored. The cleaning method includes determining to use the first stream for analysis of a sample, obtaining at least one of a result of analysis for quality control of the first stream and information that specifies a sample to be analyzed in the first stream in response to determination to use the first stream for analysis of the sample, specifying a first combination including an execution condition to which at least one of the result of analysis for quality control and the information corresponds, among the two or more combinations, and driving the one or more pumps in accordance with the cleaning method included in the first combination. 
     According to the cleaning method described in Clause 12, in the liquid chromatographic system, the stream is appropriately cleaned. 
     (Clause 13) A computer readable medium according to one aspect is a non-transitory computer readable medium having a program recorded thereon. The program, when executed by a processor of a controller, may cause the controller to perform determining to use, in a liquid chromatographic system, for analysis of a sample, a first stream including an analysis flow path including a first analysis column, obtaining at least one of a result of analysis for quality control of the first stream and information that specifies a sample to be analyzed in the first stream in response to determination to use the first stream for analysis of the sample, specifying, among two or more combinations of a cleaning method and a cleaning execution condition, a first combination including an execution condition to which at least one of the result of analysis for quality control and the information corresponds, and driving one or more pumps that supply a liquid to the first stream in accordance with the cleaning method included in the first combination. 
     According to the computer readable medium described in Clause  13 , in the liquid chromatographic system, the stream is appropriately cleaned. 
     It should be understood that the embodiment disclosed herein is illustrative and non-restrictive in every respect. The scope of the present invention is defined by the terms of the claims rather than the description of the embodiment above and is intended to include any modifications within the scope and meaning equivalent to the terms of the claims.