Patent Publication Number: US-4255326-A

Title: Nitrogen and/or sulfur containing heterocyclic azo dyes with aniline, tetrahydroquinoline and benzomorpholine couplers having sulfate group

Description:
This invention concerns novel dyes which comprise heterocyclic diazo moieties and aromatic amine couplers having sulfate groups. These dyes are substantially water soluble and are particularly useful for dyeing polyamide, wool and the like and exhibit excellent properties including fastness to light and dyeability. 
     The dyes of this invention correspond to the following general formula: ##STR1## wherein R is a heterocyclic diazo radical which may be substituted as further defined below; R 1  is selected from groups such as hydrogen, lower alkyl and lower alkoxy each of which may be substituted, halogen, acylamido, lower alkylthio and aryloxy; R 2  is selected from hydrogen, lower alkyl which may be substituted, lower alkenyl, aryl or cycloalkyl which also may be substituted, and R 2  may in conjunction with R 1  also form a 1,2,3,4-tetrahydroquinoline or a 2,3-dihydro-1,4-benzoxazine (benzomorpholine) ring; Z is a linking group such as lower alkylene; M is H + , Na + , K + , or NH 4   +  ; and m is 0, 1 or 2. The various alkyl, alkylene, alkenyl, alkoxy, alkanoyl and the like groups within the above definitions may be straight or branched chain and the types and degree of substitutions thereof and also on the cyclic moieties as further defined below must, of course, be judiciously selected as known to those skilled in the art. The term &#34;lower&#34; as used throughout the specification and claims denotes 1-6 carbons. 
     More particularly the dyes correspond to the formula above wherein R represents the following radicals I through VII: ##STR2## In these formulae, radical I may have 1-3 substituents selected from lower alkyl, lower alkoxy, thiocyano, lower alkylthio, cyano, carbamoyl, lower alkylcarbamoyl, lower alkoxycarbonyl, acyl, lower alkylsulfonyl, sulfamoyl, SO 2  NH(lower alkyl), SO 2  N(di-lower alkyl), lower alkylsulfonamido, acylamido, halogen, trifluoromethyl and SO 3  (aryl); 
     Radical II may have 1-3 substituents selected from lower alkyl, lower alkoxy, chlorine, bromine, SO 2  NH 2 , SO 2  NH(lower alkyl), and SO 2  N(di-lower alkyl); 
     Radical III may have a substituent selected from lower alkyl, lower alkoxy, halogen, lower alkylsulfonyl, SO 2  NH 2 , SO 2  NH(lower alkyl), SO 2  N(di-lower alkyl), arylsulfonyl, acylamido, aryl, arylthio, lower alkenylthio, cyclohexylthio, thiocyano, cyclohexylsulfonyl, lower alkylthio, and cyclohexyl; 
     Radical IV may have a substituent selected from lower alkyl, aryl, lower alkylthio, cyclohexylthio, and lower alkylsulfonyl; 
     Radical V may have 1 or 2 substituents selected from lower alkyl, halogen, cyano, carbamoyl, CONH lower alkyl, alkoxycarbonyl, lower alkylthio, lower alkenylthio, arylthio, cyclohexylthio, s-heterocycle, aryloxy, and lower alkoxy; 
     Radical VI may have 1 or 2 substituents selected from lower alkyl, lower alkoxycarbonyl, lower alkylthio, aryl, cyano, carbamoyl, lower alkylcarbamoyl, and lower alkylsulfonyl, and the hydrogen on the N may be replaced with lower alkyl, aryl of 6-10 carbons, lower alkylsulfonyl, arylsulfonyl, lower alkanoyl, or lower alkoxycarbonyl; and 
     Radical VII may be substituted with 1-3 groups selected from lower alkyl, cyano, lower alkoxycarbonyl, acyl, lower alkylsulfonyl, arylsulfonyl, carbamoyl, lower alkylcarbamoyl, aryl, halogen, sulfamoyl, lower alkylsulfamoyl and formyl. 
     The couplers are described more particularly by the following formulae: ##STR3## 
     In these formulae: 
     R 1  is selected from hydrogen, lower alkyl, lower alkoxy, halogen, acylamido, lower alkylthio, and aryloxy; 
     R 2  is selected from hydrogen, aryl, cycloalkyl, and lower alkyl; 
     R 3  and R 4  are each selected from hydrogen and lower alkyl; m is 0, 1 or 2; M is Na + , K + , H +  or NH 4   +  ; Z is selected from straight or branched chain lower alkylene which may be substituted, for example, with aryl, phenyl, halogen, OSO 3  M, lower alkoxy or aryloxy, --CH 2  (CH 2 ) n  X--CH 2  (CH 2 ) p  --, where n is 1, 2 or 3, p is 0, 1, 2 or 3, and X is O, S, SO 2 , --SO 2  NH--, --SO 2  N(lower alkyl)--, SO 2  N(aryl) --N(SO 2  aryl)--, --NHCO--, --NHCONH, --N(SO 2  lower alkyl), and --CON(lower alkyl); and in all of the above definitions of groups containing lower alkyl, lower alkylene, or cyclic radicals, such radicals may bear up to three substituents selected from hydroxy, lower alkoxy, aryl, aryloxy, cyclohexyl, furyl, lower alkylcyclohexyl, aroyloxy, lower alkoxycarbonyl, lower alkanoyloxy, sulfamoyl, SO 2  NH(aryl), SO.sub. 2 NH(lower alkyl), SO 2  N(di-lower alkyl), NHCOO(lower alkyl), NHCONH(lower alkyl), acylamido particularly where the acyl moiety is lower alkanoyl, lower alkylsulfonamido, succinimido, glutarimido, phthalimido, 2-pyrrolidono, cyano, carbamoyl, lower alkylcarbamoyl, lower alkoxyalkoxy, lower alkylthio, halogen, arylthio, lower alkylsulfonyl and arylsulfonyl. 
     The dyes of this invention impart orange to blue shades on fibers, particularly polyamides, and are especially useful for dyeing polyamide (nylon) carpets, giving good fastness to light, ozone, oxides of nitrogen, washing, sublimation, crocking, and the like, and having good leveling, transfer, exhaustion and build properties. 
     The heterocyclic amines used in this invention are prepared according to known procedures. The dyes may be prepared as follows: 
     Method I 
     An intermediate coupler containing one or more hydroxy groups may be reacted with sulfuric acid to produce a sulfate ester, which is then coupled with a diazonium salt to give the dye, as follows: ##STR4## 
     Method II 
     An intermediate coupler containing one or more hydroxy groups may be coupled with the diazonium salt and then the dye reacted with sulfuric acid to produce the sulfate ester, as follows: ##STR5## 
     The dyes may be isolated when M is H + , but are usually isolated as the sodium or potassium salts. 
    
    
     The following examples will further illustrate these preparative methods. 
     COUPLER PREPARATIONS 
     EXAMPLE 1 
     Preparation of N-Ethyl-N-2-sulfatoethyl-m-toluidine 
     To 75 ml of concentrated sulfuric acid is added 53.8 g. of N-ethyl-N-2-hydroxyethyl-m-toluidine with stirring, keeping the temperature below 50° C. The solution is stirred for 2 hrs. and the temperature allowed to drop. Thin-layer chromatography shows an essentially complete reaction. The viscous reaction mixture is drowned in ice-water and diluted to a total volume of about 900 ml. the coupler solution is then used to prepare the dyes without further treatment. 
     EXAMPLE 2 
     Preparation of N-Ethyl-N-2-sulfatoethylaniline 
     To 25 ml of concentrated sulfuric acid is added 16.5 g. of N-ethyl-N-2-hydroxyethylaniline at less than 40° C. After stirring 2 hrs. and allowing the temperature to drop, the reaction mixture is added to 200 g. of ice and diluted to a total volume of about 250 ml. An aliquot of this coupler solution is used without further treatment. 
     EXAMPLE 3 
     Preparation of 2,7-Dimethyl-N-(2,3-disulfatopropyl) 1,2,3,4-tetrahydroquinoline 
     To 40 g. of concentrated sulfuric acid is added 11.75 g. of N-(2,3-dihydroxypropyl)-2,7-dimethyl-1,2,3,4-tetrahydroquinoline at about 50° C. The material is difficult to dissolve and requires stirring for several hours at room temperature. After solution is completed, stirring is continued for 1 hr. and the solution drowned in 100 g. ice. The solution is used without further treatment to prepare dyes. 
     EXAMPLE 4 
     Preparation of N,N-bis(2-Sulfatoethyl)-m-toluidine 
     N,N-bis(2-Hydroxyethyl)-m-toluidine (1 g.) is added to 3 g. of concentrated sulfuric acid, allowed to stand at room temperature, and the reaction mixture added to 20 g. of ice. The solution is used to prepare dyes. 
     EXAMPLE 5 
     Preparation of N-(2-Sulfatoethyl)-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline 
     To 250 ml of concentrated sulfuric acid is added 120 g. of N-(2-hydroxyethyl)-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline at less than 30° C. The solution is stirred for 2 hrs. and drowned onto 1250 g. of ice and water. After stirring for about 30 min., the white solid which precipitates is collected by filtration, washed with 10% sodium chloride solution, and dried at 60° C. 
     EXAMPLE 6 
     Preparation of N-(2-(Sulfatoethyl)-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline 
     N-(2-Hydroxyethyl)-1,2,3,4-tetrahydro-2,2,4-trimethyl-quinoline (110 g.) is treated exactly as in Example 5 to yield the sulfate product which is a white solid. 
     EXAMPLE 7 
     Preparation of N-(2-(Sulfatoethyl)-2,3-dihydro-3,6-dimethyl-1,4-benzoxazine 
     N-(2-Hydroxyethyl)-2,3-dihydro-3,6-dimethyl-1,4-benzoxazine (25 g.) is added at about 30° C. to concentrated sulfuric acid (50 ml). After solution is complete, stirring is continued for 1 hr. and the reaction solution drowned in ice-water to produce a total volume of about 500 ml. The coupler solution is used without further treatment. 
     The following are typical coupler types bearing hydroxy groups which may be treated in a similar manner as described above to produce sulfate groups. ##STR6## 
     The tetrahydroquinoline and 2,3-dihydro-1,4-benzoxazine couplers can be prepared in a similar manner as illustrated by the aniline derivatives above. 
     PREPARATION OF THE DYES--METHOD I 
     EXAMPLES 8-17 
     Diazotization and Coupling of 2-Amino-6-methylbenzothiazole 
     To 150 g. of 60% acetic acid containing 10 g. of concentrated H 2  SO 4  is added 8.2 g. (0.05 mole) of 2-amino-6-methylbenzothiazole at room temperature. The solution is cooled to -5° C., and a solution of 3.6 g. NaNO 2  in 20 ml of concentrated H 2  SO 4  is added below 0° C. The reaction mixture is stirred at -5° to 0° C. for 1.5 hours. Each of the couplers (0.005 mole) listed below as Examples 8-17 is added to water, or a 0.005 mole aliquot of the coupler in dilute sulfuric acid is added to water, and cooled in an ice bath. 
     To each chilled coupler is added a 0.005 mole aliquot of the diazonium solution. The coupling mixture is treated with enough potassium acetate to neutralize the mineral acid. Water is added to the coupling mixture to a total volume of about 200 ml and the dyes collected by filtration, washed with 10% KCl solution, and dried in air. The dyes usually are admixed with about an equal weight of K 2  SO 4  and are used for dyeing without further purification to produce red shades on polyamides. 
     
         ______________________________________                                    
Example                                                                   
No.                                                                       
______________________________________                                    
8      N-Ethyl-N(-2-sulfatoethyl)aniline                                  
9      N-Ethyl-N-(2-sulfatoethyl)-m-toluidine                             
10     N-(2-Sulfatoethyl)-o-chloroaniline                                 
11     2-Methoxy-5-methyl-N-(2-sulfatoethyl)aniline                       
12     N,N-bis(Sulfatoethyl)-m-toluidine                                  
13     N-(2-Sulfatoethyl)-1,2,3,4-tetrahydro-2,2,4,7-                     
       tetramethylquinoline                                               
14     N-(2-Sulfatoethyl)-1,2,3,4-tetrahydro-2,2,4-                       
       trimethylquinoline                                                 
15     2,7-Dimethyl-N-(2-sulfatoethyl)-1,2,3,4-                           
       tetrahydroquinoline                                                
16     2,3-Dihydro-3,6-dimethyl-N-(2-sulfatoethyl)-                       
       1,4-benzoxazine                                                    
17     2,3-Dihydro-3-methyl-6-methoxy-N-(2-sulfatoethyl)-                 
       1,4-benzoxazine                                                    
______________________________________                                    
 
    
     EXAMPLES 18-27 
     Diazotization and Coupling of 3-Amino-2,1-benzisothiazole 
     To 25 ml of concentrated H 2  SO 4  is added 3.6 g. of NaNO 2  portionwise below 80° C. The solution is cooled and 50 ml of 1:5 acid (1 part propionic, 5 parts acetic acid) is added below 20° C. The mixture is further cooled and 3-amino-2,1-benzisothiazole (7.5 g., 0.05 m) is added, followed by 50 ml of 1:5 acid, all at 0°-5° C. The diazonium, after stirring at 0°-5° C. for 1 hr., is coupled to the couplers of Examples 8-17  in a similar manner as above to produce violet to reddish blue dyes for polyamides. 
     EXAMPLES 28-37 
     Diazotization and Coupling of 2-Amino-5-ethylthio-1,3,4-thiadiazole 
     Sodium nitrite (3.6 g.) is added portionwise to 25 ml of concentrated H 2  SO 4 . The solution is cooled and 100 ml of 1:5 acid is added below 15° C. The mixture is cooled and 8.05 g. (0.05 m) of 2-amino-5-ethylthio-1,3,4-thiadiazole is added below 10° C. After stirring at 0°-5° C. for 2 hrs., a 0.005 m aliquot of the diazonium salt is coupled to 0.005 m of the couplers of Examples 8-17 to produce red dyes for polyamides. 
     EXAMPLES 38-47 
     Diazotization of 5-Amino-3-ethylthio-1,2,4-thiadiazole 
     5-Amino-3-ethylthio-1,2,4-thiadiazole (8.05 g., 0.05 m) is diazotized exactly as described in Examples 28-37 and a 0.005 m aliquot coupled to 0.005 m portion of the couplers of Examples 8-17 in the manner previously illustrated. 
     EXAMPLES 48-57 
     Diazotization of 5-Amino-3-methyl-4-cyano isothiazole 
     To 25 ml of concentrated H 2  SO 4  is added 3.6 g. of NaNO 2  allowing the temperature to rise. The solution is cooled and 50 ml of 1:5 acid is added below 10° C. Stirring is continued and 6.95 g. (0.05 m) of 5-amino-3-methyl-4-cyanoisothiazole is added below 5° C., followed by an additional 50 ml of 1:5 acid. After stirring at 0°-5° C. for 2 hrs., a 0.005 m aliquot of the diazonium salt is coupled to 0.005 m of the couplers of Examples 8-17 as previously described to produce rubine to violet dyes for polyamides. 
     EXAMPLES 58-67 
     Diazotization of 5-Amino-4-carbomethoxypyrazole 
     Nitrosyl sulfuric acid is prepared by adding 3.6 g. NaNO 2  to 25 ml of concentrated H 2  SO 4 . The solution is cooled and 100 ml of 1:5 acid is added below 20° C. After further cooling, 5-amino-4-carbomethoxypyrazole (7.05 g., 0.05 m) is added at 0°-5° C. and stirring continued for 2 hrs. A 0.005 m aliquot of the diazonium solution is coupled to 0.005 m. of the couplers of Examples 8-17 in the manner previously described to produce red dyes for polyamides. 
     EXAMPLES 68-77 
     Diazotization of 2-Amino-3-carbomethoxy-5-isobutyrylthiophene 
     To 150 g. of 60% aqueous acetic acid is added 11.35 g. (0.05 m) of 2-amino-3-carbomethoxy-5-isobutylthiophene at room temperature. Ten grams of concentrated onc. H 2  SO 4  is added and the mixture cooled to 0° C. A solution of 3.6 g NaNO 2  in 25 ml of conc. H 2  SO 4  is added below 10° C. and stirring continued for 1 hr. at 0°-5° C. A 0.005 m aliquot of this diazonium salt is coupled to 0.005 m portions of the couplers of Examples 8-17 as previously illustrated to produce violet to reddish-blue dyes for polyamides. 
     PREPARATION OF DYES--METHOD II 
     EXAMPLE 78 
     Reaction of Hydroxy Containing Dye With Sulfuric Acid and NaOH ##STR7## 
     To 50 g. of concentrated H 2  SO 4  is added 10 g. of Dye I portionwise, allowing the temperature to rise (40° C.). The temperature is then increased to about 50°-55° C. for about 30 min. After cooling to room temperature, the reaction mixture is added to 50 g. of ice and 20 ml of acetic acid. A solution of 105 g. of 50% NaOH is added, with ice for internal cooling, below 30° C. The slurry was diluted with 200 ml of water and then filtered. The solid is dried at room temperature and contains about an equal weight of dye and sodium sulfate. The dye produces bright bluish-red shades on nylon carpet. 
     EXAMPLE 79 ##STR8## 
     Dye II (1 g.) is added to 3 g. of concentrated H 2  SO 4  and the mixture warmed at 45°-50° C. to complete solution. After 15 min. 10 g. of ice is added and 50% potassium hydroxide solution is added until pH of about 8 is obtained. Water (75 ml) is added and the dye collected by filtration and dried in air. The dye produces bright blue shades on polyamide fibers. 
     
                                           TABLE I                                 
__________________________________________________________________________
 ##STR9##                                                                 
Substituents on                                                           
Ring A     (R.sub.1)m R.sub.2       Z                M                    
__________________________________________________________________________
None       None       C.sub.2 H.sub.5                                     
                                    CH.sub.2 CH.sub.2                     
                                                     K.sup.+              
&#34;          &#34;          C.sub.6 H.sub.11                                    
                                    &#34;                &#34;                    
&#34;          &#34;          C.sub.6 H.sub.5                                     
                                    &#34;                &#34;                    
&#34;          3CH.sub.3  C.sub.2 H.sub.5                                     
                                    &#34;                &#34;                    
&#34;          &#34;          CH.sub.2 C.sub.6 H.sub. 5                           
                                    &#34;                &#34;                    
&#34;          &#34;          CH.sub.2 CH.sub.2 OCH.sub.3                         
                                    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2   
                                                     &#34;                    
&#34;          &#34;          CH.sub.2 CH.sub.2 CONH.sub.2                        
                                    CH.sub.2 CH.sub.2                     
                                                     &#34;                    
&#34;          &#34;          CH.sub.2 CH.sub.2 Cl                                
                                    &#34;                &#34;                    
&#34;          3-NHCOCH.sub.3                                                 
                      C.sub.2 H.sub.5                                     
                                    &#34;                &#34;                    
&#34;          2-CH.sub.3 -5-NHCOCH.sub.3                                     
                      H             &#34;                &#34;                    
&#34;          2-OCH.sub.3 -5-CH.sub.3                                        
                      &#34;             &#34;                &#34;                    
&#34;          2-Cl       &#34;             &#34;                &#34;                    
&#34;          2-CH.sub.3 &#34;             &#34;                &#34;                    
&#34;          2,5-di-Cl  &#34;             &#34;                &#34;                    
&#34;          2-OCH.sub.3 -5-Cl                                              
                      &#34;             &#34;                &#34;                    
6-CH.sub.3 2-OCH.sub.3 -5-CH.sub.3                                        
                      &#34;             &#34;                &#34;                    
&#34;          2,5-diCH.sub.3                                                 
                      &#34;             &#34;                Na.sup.+             
&#34;          3-CH.sub.3                                                     
                       ##STR10##    &#34;                &#34;                    
&#34;          3-CH.sub.3                                                     
                       ##STR11##     CH.sub.2 CH(CH.sub.2 Cl)             
                                                     &#34;                    
&#34;          3-CH.sub.3                                                     
                       ##STR12##    CH.sub.2 CH.sub.2                     
                                                     NH.sub.4.sup.+       
&#34;          3-CH.sub.3                                                     
                       ##STR13##    &#34;                K.sup.+              
&#34;3-CH.sub.3                                                               
           CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                          
                      &#34;             &#34;                                     
&#34;          3-CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3             
                                    &#34;                &#34;                    
6-OCH.sub.3                                                               
           None       CH.sub.3      CH.sub.2 CH.sub.2                     
                                                     &#34;                    
&#34;          3-CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2                         
                                    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2  
                                                     &#34;                    
&#34;          &#34;          CH.sub.2 C.sub.6 H.sub.11                           
                                    CH.sub.2 CH.sub.2                     
                                                     &#34;                    
&#34;          &#34;          CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                  
                                    &#34;                &#34;                    
6-C1       &#34;          CH(CH.sub.3).sub.2                                  
                                    &#34;                &#34;                    
&#34;          H          CH.sub.2 CH.sub.3                                   
                                    &#34;                K.sup.+              
&#34;          &#34;          CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2       
                      H.sub.5       &#34;                &#34;                    
5,6-di-Cl  3-CH.sub.3 CH.sub.2 CH.sub.3                                   
                                    &#34;                &#34;                    
6-SO.sub.2 CH.sub.3                                                       
           &#34;          &#34;             &#34;                &#34;                    
6-CN       &#34;          &#34;             &#34;                &#34;                    
6-CONH.sub.2                                                              
           &#34;          &#34;             &#34;                &#34;                    
6-COCH.sub.3                                                              
           3-NHCOC.sub.6 H.sub.5                                          
                      &#34;             &#34;                &#34;                    
6-COC.sub.6 H.sub.5                                                       
           3-NHCONHC.sub.2 H.sub.5                                        
                      &#34;             &#34;                &#34;                    
6-COOC.sub.2 H.sub.5                                                      
           3-NHCOCH.sub.2 OCH.sub.3                                       
                      &#34;             &#34;                &#34;                    
6-SO.sub.2 NH.sub.2                                                       
           3-NHCOC.sub.6 H.sub.11                                         
                      &#34;             &#34;                &#34;                    
6-SO.sub.2 N(CH.sub.3).sub.2                                              
           3-NHCOOC.sub.2 H.sub.5                                         
                      &#34;             CH.sub.2 CH(CH.sub.3)                 
                                                     &#34;                    
6-SO.sub.2 NHC.sub.2 H.sub.4 OCH.sub.3                                    
           3-NHCOCH.sub.2 CN                                              
                      &#34;             CH.sub.2 CH(CH.sub.2 OCH.sub.3)       
                                                     &#34;                    
6-NHCOCH.sub.3                                                            
           &#34;          &#34;             CH.sub.2 CH.sub.2                     
                                                     &#34;                    
4-CF.sub.3 None       &#34;             &#34;                &#34;                    
6-SO.sub.3 C.sub.6 H.sub.5                                                
           &#34;          &#34;             &#34;                &#34;                    
6-OC.sub.2 H.sub.5                                                        
           3-CH.sub.3 &#34;             CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2  
                                                     &#34;                    
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2   
                                    CH.sub.2 CH.sub.2 CH.sub.2            
                                                     &#34;                    
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)
                                    CH.sub.2 CH.sub.2                     
                                                     &#34;                    
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2 N(COCH.sub.3)CH.sub.
                                    2 CH.sub.2       &#34;                    
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2 
                                    CH.sub.2         &#34;                    
6-SCH.sub.3                                                               
           &#34;          &#34;             CH.sub.2 CH.sub.2                     
                                                     &#34;                    
6-SCN      &#34;          &#34;             &#34;                &#34;                    
6-CH.sub.3 &#34;          &#34;             CH.sub.2 CH.sub.2 CONHC.sub.2         
                                                     &#34;.sub.4              
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2 NHCOCH.sub.2        
                                                     &#34;                    
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.2 
                                    CH.sub.2         &#34;                    
&#34;          3-NHCOC.sub.6 H.sub.5                                          
                      &#34;             CH.sub.2 CH.sub.2                     
                                                     &#34;                    
&#34;          3-NHCOOC.sub.2 H.sub.5                                         
                      &#34;             &#34;                &#34;                    
&#34;          3-CH.sub.3 CH.sub.2 CH.sub.2 OSO.sub.3 Na                      
                                    &#34;                Na.sup.+             
&#34;          &#34;          C.sub.2 H.sub.5                                     
                                    CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2     
                                                     &#34;                    
__________________________________________________________________________
 
    
     
                                           TABLE 2                                 
__________________________________________________________________________
 ##STR14##                                                                
Substituents on                                                           
Ring A    (R.sub.1)m                                                      
                    R.sub.3                                               
                       Z     M                                            
__________________________________________________________________________
None      None      CH.sub.3                                              
                       CH.sub.3                                           
                             CH.sub.2 CH.sub.2  K.sup.+                   
&#34;         &#34;         H  CH.sub.3                                           
                             &#34;                  &#34;                         
&#34;         &#34;         H  CH.sub.3                                           
                             &#34;                  &#34;                         
&#34;         7-CH.sub.3                                                      
                    &#34;  &#34;     &#34;                                            
&#34;         &#34;         CH.sub. 3                                             
                       &#34;     &#34;                  &#34;                         
&#34;         7-CH.sub.3                                                      
                    H  CH(CH.sub.3).sub.2                                 
                             &#34;                  &#34;                         
&#34;         7-OCH.sub.3                                                     
                    &#34;  CH.sub.3                                           
                             &#34;                  &#34;                         
&#34;         5-OCH.sub.3, 8-CH.sub.3                                         
                    &#34;  &#34;     &#34;                  &#34;                         
&#34;         5,8-di-OCH.sub.3                                                
                    &#34;  &#34;     &#34;                  &#34;                         
&#34;         5,8-di-CH.sub.3                                                 
                    &#34;  &#34;     &#34;                  &#34;                         
&#34;         7-Cl      &#34;  &#34;     &#34;                  &#34;                         
&#34;         5,8-di-Cl &#34;  &#34;     &#34;                  &#34;                         
6-CH.sub.3                                                                
          None      &#34;  &#34;     &#34;                  Na.sup.+                  
&#34;         5-OCH.sub.3, 8-CH.sub.3                                         
                    CH.sub.3                                              
                       &#34;     &#34;                  &#34;                         
&#34;         7-NHCHO   &#34;  &#34;     &#34;                  &#34;                         
&#34;         7-NHCOCH.sub.3                                                  
                    &#34;  &#34;     &#34;                  &#34;                         
&#34;         7-NHCOCH.sub.2 OCH.sub.3                                        
                    &#34;  &#34;     &#34;                  &#34;                         
&#34;         7-NHCOOC.sub.2 H.sub.5                                          
                    &#34;  &#34;     &#34;                  &#34;                         
&#34;         7-NHCOC.sub.6 H.sub.5                                           
                    &#34;  &#34;     &#34;                  &#34;                         
&#34;         7-NHCONHC.sub.2 H.sub.5                                         
                    &#34;  &#34;     &#34;                  K.sup.+                   
&#34;         7-NHCOC.sub.6 H.sub.11                                          
                    &#34;  &#34;     &#34;                  &#34;                         
6-OCH.sub.3                                                               
          None      &#34;  &#34;     &#34;                  &#34;                         
&#34;         7-CH.sub.3                                                      
                    H  &#34;     &#34;                  &#34;                         
&#34;         &#34;         &#34;  H     &#34;                  &#34;                         
6-OCH.sub.2 CH.sub.3                                                      
          &#34;         &#34;  CH.sub.3                                           
                             &#34;                  &#34;                         
6-SCH.sub.3                                                               
          &#34;         &#34;  &#34;     &#34;                  &#34;                         
6-SCN     &#34;         &#34;  &#34;     &#34;                  &#34;                         
6-SO.sub.2 NH.sub.2                                                       
          &#34;         &#34;  &#34;     &#34;                  &#34;                         
6-SO.sub.2 NHC.sub.4 H.sub.9 -n                                           
          &#34;         &#34;  &#34;     &#34;                  &#34;                         
6-SO.sub.2 N(CH.sub.3).sub.2                                              
          7-OCH.sub.3                                                     
                    &#34;  &#34;     &#34;                  &#34;                         
6-SO.sub.3 C.sub.6 H.sub.5                                                
          7-CH.sub.3                                                      
                    &#34;  &#34;     &#34;                  &#34;                         
6-CN      &#34;         &#34;  &#34;     &#34;                  &#34;                         
6-CONH.sub.2                                                              
          &#34;         &#34;  &#34;     &#34;                  &#34;                         
4-COOCH.sub.3                                                             
          &#34;         &#34;  &#34;     &#34;                  &#34;                         
6-COCH.sub.3                                                              
          &#34;         &#34;  &#34;     &#34;                  &#34;                         
6-COC.sub.6 H.sub.5                                                       
          &#34;         &#34;  &#34;     &#34;                  &#34;                         
6-Cl      None      &#34;  &#34;     &#34;                  &#34;                         
5,6-di-Cl &#34;         &#34;  &#34;     &#34;                  &#34;                         
4-Br      &#34;         &#34;  &#34;     &#34;                  &#34;                         
4-CF.sub.3                                                                
          &#34;         &#34;  &#34;     &#34;                  &#34;                         
6-NHCOCH.sub.3                                                            
          7-CH.sub.3                                                      
                    &#34;  &#34;     &#34;                  &#34;                         
6-SO.sub.2 CH.sub.3                                                       
          &#34;         &#34;  &#34;     &#34;                  &#34;                         
6-CH.sub.3                                                                
          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2         
                                                &#34;                         
&#34;         &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2         
                                                &#34;                         
&#34;         &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2 CH.sub.2 
                                                &#34;                         
&#34;         &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.sub.
                             2 CH.sub.2         &#34;                         
&#34;         &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2        
                             CH.sub.2           &#34;                         
&#34;         &#34;         &#34;  &#34;      CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.2     
                                                &#34;                         
None      &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.       
                                                &#34;                         
6-SC.sub.2 H.sub.4 CN                                                     
          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 N(COC.sub.6 H.sub.5)CH.sub.
                             2 CH.sub.2         &#34;                         
6-NHCOCH.sub.2 CN                                                         
          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 (CH.sub.3)                 
                                                &#34;                         
6-CH.sub.3                                                                
          &#34;         &#34;  &#34;     CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2            
                                                Na.sup.+                  
&#34;         &#34;         &#34;  &#34;     CH.sub.2 CH(CH.sub.2 Cl)                     
                                                &#34;                         
&#34;         &#34;         &#34;  &#34;     CH.sub.2 CH(CH.sub.2 OCH.sub.3)              
                                                &#34;                         
&#34;         &#34;         &#34;  &#34;     CH.sub.2 CH(C.sub.6 H.sub.5)                 
                                                &#34;                         
&#34;         &#34;         &#34;  &#34;     CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)       
                                                &#34;                         
&#34;         &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3)SO.sub.
                             2 CH.sub.2 CH.sub.2                          
                                                &#34;                         
6-COOC.sub. 2 H.sub.4 OCH.sub.3                                           
          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2                   
                                                &#34;                         
__________________________________________________________________________
 
    
     
                                           TABLE 3                                 
__________________________________________________________________________
 ##STR15##                                                                
Ring A      (R.sub.1)m                                                    
                      R.sub.3                                             
                          Z                  M                            
__________________________________________________________________________
None        None      H   CH.sub.2 CH.sub.2  Na.sup.+                     
&#34;           6-CH.sub.3                                                    
                      &#34;   &#34;                  &#34;                            
&#34;           &#34;         3-CH.sub.3                                          
                          &#34;                  &#34;                            
&#34;           6-OCH.sub.3                                                   
                      &#34;   &#34;                  &#34;                            
6-CH.sub.3  &#34;         H   &#34;                  &#34;                            
&#34;           6-CH.sub.3                                                    
                      3-CH.sub.3                                          
                          CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2             
                                             &#34;                            
4-CH.sub.3  &#34;         &#34;   CH.sub.2 CH.sub.2  &#34;                            
4-Cl        &#34;         &#34;   &#34;                  &#34;                            
4-CF.sub.3  &#34;         &#34;   &#34;                  &#34;                            
4,7-di-CH.sub.3                                                           
            &#34;         &#34;   &#34;                  &#34;                            
4,7-di-Cl   &#34;         &#34;   &#34;                  &#34;                            
4-OCH.sub.3, 7-Cl                                                         
            &#34;         &#34;   &#34;                  &#34;                            
4-OCH.sub.3, 5-CH.sub.3                                                   
            &#34;         &#34;   &#34;                  &#34;                            
6-OCH.sub.3 &#34;         &#34;   &#34;                  &#34;                            
&#34;           6-NHCOCH.sub.3                                                
                      &#34;   &#34;                  K.sup.+                      
&#34;           6-NHCOC.sub.6 H.sub.5                                         
                      &#34;   &#34;                  &#34;                            
&#34;           6-NHCOC.sub.4 H.sub.9n                                        
                      &#34;   &#34;                  &#34;                            
&#34;           6-NHCONHC.sub.2 H.sub.5                                       
                      &#34;   &#34;                  &#34;                            
&#34;           6-NHCOCH.sub.2 OCH.sub.3                                      
                      &#34;   &#34;                  &#34;                            
6-OC.sub.4 H.sub.9n                                                       
            6-NHCOCH.sub.2 CN                                             
                      &#34;   &#34;                  &#34;                            
6-SCH.sub.3 6-CH.sub.3                                                    
                      &#34;   &#34;                  Na.sup.+                     
6-SCN       &#34;         &#34;   &#34;                  &#34;                            
6-SO.sub.2 CH.sub.3                                                       
            &#34;         &#34;   &#34;                  &#34;                            
6-SO.sub.2 NH.sub.2                                                       
            &#34;         &#34;   &#34;                  &#34;                            
6-SO.sub.2 NHC.sub.2 H.sub.5                                              
            &#34;         &#34;   &#34;                  &#34;                            
6-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                       
            &#34;         &#34;   &#34;                  &#34;                            
6-SO.sub.2 NHC.sub.2 H.sub.4 OCH.sub.3                                    
            &#34;         &#34;   &#34;                  &#34;                            
6-SO.sub.3 C.sub.6 H.sub.5                                                
            &#34;         &#34;   &#34;                  &#34;                            
5,6-di-Cl   &#34;         &#34;   &#34;                  &#34;                            
&#34;           6-NHCHO   &#34;   &#34;                  &#34;                            
6-CN        6-CH.sub.3                                                    
                      &#34;   &#34;                  &#34;                            
6-CONH.sub.2                                                              
            &#34;         &#34;   &#34;                  &#34;                            
6-COOC.sub.2 H.sub.5                                                      
            &#34;         &#34;   &#34;                  &#34;                            
6-COCH.sub.3                                                              
            &#34;         &#34;   &#34;                  &#34;                            
6-COC.sub.6 H.sub.5                                                       
            &#34;         &#34;   &#34;                  &#34;                            
4-Br6-SO.sub.2 CH.sub.3                                                   
            &#34;         &#34;   &#34;                  &#34;                            
6-SCH.sub.2 CH.sub.2 CN                                                   
            &#34;         &#34;   &#34;                  &#34;                            
6-SO.sub.2 CH.sub.2 CH.sub.2 CN                                           
            &#34;         &#34;   &#34;                  &#34;                            
6-CH.sub.3  &#34;         &#34;   CH.sub.2 CH(CH.sub.3)                           
                                             &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH(C.sub.6 H.sub.5)                    
                                             &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH(CH.sub.2 Cl)                        
                                             &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH(OSO.sub.3 K)CH.sub.2                
                                             &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)          
                                             &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2            
                                             &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2            
                                             &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2 CH.sub.2    
                                             &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3 )CH.sub.2 
                          CH.sub.2           &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH.sub.2 N(SO.sub.2 C.sub.6 H.sub.5)CH.
                          sub.2 CH.sub.2     &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH.sub.2 SO.sub.2 N(CH.sub.3)CH.sub.2  
                          CH.sub.2           &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH.sub.2 NHCOCH.sub.2                  
                                             &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.2  
                          CH.sub.2           &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2         
                                             &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2         
                          CH.sub.2 CH.sub.2  &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH.sub.2 SO.sub.2 N(C.sub.6 H.sub.5)CH.
                          sub.2 CH.sub.2     &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH.sub.2 NHCONHCH.sub.2 CH.sub.2       
                                             &#34;                            
6-COOCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                   
            &#34;         &#34;   CH.sub.2 CH.sub.2 CH.sub.2                      
                                             &#34;                            
&#34;           &#34;         &#34;   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2SCH.sub.2    
                          CH.sub.2           &#34;                            
__________________________________________________________________________
 
    
     
                                           TABLE 4                                 
__________________________________________________________________________
 ##STR16##                                                                
Substitution                                                              
Ring B     (R.sub.1)m R.sub.2       Z                M                    
__________________________________________________________________________
6-CH.sub.3 None       C.sub.2 H.sub.5                                     
                                    CH.sub.2 CH.sub.2                     
                                                     K.sup.+              
None       &#34;          C.sub.6 H.sub.11                                    
                                    &#34;                &#34;                    
&#34;          &#34;          C.sub.6 H.sub.5                                     
                                    &#34;                &#34;                    
6-CH.sub.3 3CH.sub.3  C.sub.2 H.sub.5                                     
                                    &#34;                &#34;                    
None       &#34;          CH.sub.2 C.sub.6 H.sub.5                            
                                    &#34;                &#34;                    
&#34;          &#34;          CH.sub.2 CH.sub.2 OCH.sub.3                         
                                    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2   
                                                     &#34;                    
&#34;          &#34;          CH.sub.2 CH.sub.2 CONH.sub.2                        
                                    CH.sub.2 CH.sub.2                     
                                                     &#34;                    
&#34;          &#34;          CH.sub.2 CH.sub.2 Cl                                
                                    &#34;                &#34;                    
&#34;          3-NHCOCH.sub.3                                                 
                      C.sub.2 H.sub.5                                     
                                    &#34;                &#34;                    
&#34;          2-CH.sub.35-NHCOCH.sub.3                                       
                      H             &#34;                &#34;                    
6-OCH.sub.3                                                               
           2-OCH.sub.35-CH.sub.3                                          
                      &#34;             &#34;                &#34;                    
&#34;          2-Cl       &#34;             &#34;                &#34;                    
None       2-CH.sub.3 &#34;             &#34;                &#34;                    
&#34;          2,5-di-Cl  &#34;             &#34;                &#34;                    
&#34;          2-OCH.sub.35-Cl                                                
                      &#34;             &#34;                &#34;                    
6-CH.sub.3 2-OCH.sub.35-CH.sub.3                                          
                      &#34;             &#34;                &#34;                    
None       2,5-di-CH.sub.3                                                
                      &#34;             &#34;                &#34;                    
&#34;          3-CH.sub.3                                                     
                       ##STR17##    &#34;                &#34;                    
&#34;          3-CH.sub.3                                                     
                       ##STR18##    CH.sub.2 CH(CH.sub.2 Cl)              
                                                     &#34;                    
&#34;          3-CH.sub.3                                                     
                       ##STR19##    CH.sub.2 CH.sub.2                     
                                                     NH.sub.4.sup.+       
&#34;          3-CH.sub.3                                                     
                       ##STR20##    &#34;                K.sup.+              
&#34;          3-CH.sub.3 CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3               
                                    &#34;                &#34;                    
&#34;          3-CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3             
                                    &#34;                &#34;                    
5-Cl       None       CH.sub.3      CH.sub.2 CH.sub.2                     
                                                     &#34;                    
5-Br       3-CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2                         
                                    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2  
                                                     &#34;                    
6-SO.sub.2 NH.sub.2                                                       
           &#34;          CH.sub.2 C.sub.6 H.sub.11                           
                                    CH.sub.2 CH.sub.2                     
                                                     &#34;                    
6-SO.sub.2 NHC.sub.2 H.sub.5                                              
           &#34;          CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                  
                                    &#34;                &#34;                    
6-SO.sub.2 N(CH.sub.3).sub.2                                              
           &#34;          CH(CH.sub.3).sub.2                                  
                                    &#34;                &#34;                    
6-SO.sub.2 NHC.sub.3 H.sub.6 OCH.sub.3                                    
           H          CH.sub.2 CH.sub.3                                   
                                    &#34;                K.sup.+              
5-Cl       &#34;          CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2       
                      H.sub.5       &#34;                &#34;                    
&#34;          3-CH.sub.3 CH.sub.2 CH.sub.3                                   
                                    &#34;                &#34;                    
&#34;          &#34;          &#34;             &#34;                &#34;                    
&#34;          &#34;          &#34;             &#34;                &#34;                    
&#34;          &#34;          &#34;             &#34;                &#34;                    
None       3-NHCOC.sub.6 H.sub.5                                          
                      &#34;             &#34;                &#34;                    
&#34;          3-NHCONHC.sub.2 H.sub.5                                        
                      &#34;             &#34;                &#34;                    
&#34;          3-NHCOCH.sub.2 OCH.sub.3                                       
                      &#34;             &#34;                &#34;                    
&#34;          3-NHCOC.sub.6 H.sub.11                                         
                      &#34;             &#34;                &#34;                    
&#34;          3-NHCOOC.sub.2 H.sub.5                                         
                      &#34;             CH.sub.2 CH(CH.sub.3)                 
                                                     &#34;                    
&#34;          3-NHCOCH.sub.2 CN                                              
                      &#34;             CH.sub.2 CH(CH.sub.2 OCH.sub.3)       
                                                     &#34;                    
6-SO.sub.2 NHCH.sub.3                                                     
           &#34;          &#34;             CH.sub.2 CH.sub.2                     
                                                     &#34;                    
&#34;          None       &#34;             &#34;                &#34;                    
&#34;          &#34;          &#34;             &#34;                &#34;                    
None       3-CH.sub.3 &#34;             CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2  
                                                     &#34;                    
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2   
                                    CH.sub.2 CH.sub.2 CH.sub.2            
                                                     &#34;                    
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)
                                    CH.sub.2 CH.sub.2                     
                                                     &#34;                    
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2 N(COCH.sub.3)CH.sub.
                                    2 CH.sub.2       &#34;                    
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2 
                                    CH.sub.2         &#34;                    
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2                     
                                                     &#34;                    
&#34;          &#34;          &#34;             &#34;                &#34;                    
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2 CONHC.sub.2         
                                                     &#34;.sub.4              
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2 NHCOCH.sub.2        
                                                     &#34;                    
&#34;          &#34;          &#34;             CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.2 
                                    CH.sub.2         &#34;                    
&#34;          3-NHCOC.sub.6 H.sub.5                                          
                      &#34;             CH.sub.2 CH.sub.2                     
                                                     &#34;                    
&#34;          3-NHCOOC.sub.2 H.sub.5                                         
                      &#34;             &#34;                &#34;                    
6-CH.sub.3 3-CH.sub.3 CH.sub.2 CH.sub.2 OSO.sub.3 Na                      
                                    &#34;                Na.sup.+             
None       &#34;          C.sub.2 H.sub.5                                     
                                    CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2     
                                                     &#34;                    
__________________________________________________________________________
 
    
     
                                           TABLE 5                                 
__________________________________________________________________________
 ##STR21##                                                                
Substituents on                                                           
Ring B   (R.sub.1).sub.m                                                  
                  R.sub.3                                                 
                     R.sub.4                                              
                          Z                  M                            
__________________________________________________________________________
6-CH.sub.3 None      CH.sub.3                                             
                        CH.sub.3                                          
                              CH.sub.2 CH.sub.2  K.sup.+                  
&#34;          &#34;         H  CH.sub.3                                          
                              &#34;                  &#34;                        
&#34;          7-CH.sub.3                                                     
                     &#34;  &#34;     &#34;                  &#34;                        
&#34;          &#34;         CH.sub.3                                             
                        &#34;     &#34;                  &#34;                        
&#34;          7-CH.sub.3                                                     
                     H  CH(CH.sub.3).sub.2                                
                              &#34;                  &#34;                        
None       7-OCH.sub.3                                                    
                     &#34;  CH.sub.3                                          
                              &#34;                  &#34;                        
&#34;          5-OCH.sub.3, 8-CH.sub.3                                        
                     &#34;  &#34;     &#34;                  &#34;                        
&#34;          5,8-di-OCH.sub.3                                               
                     &#34;  &#34;     &#34;                  &#34;                        
&#34;          5,8-di-CH.sub.3                                                
                     &#34;  &#34;     &#34;                  &#34;                        
&#34;          7-Cl      &#34;  &#34;     &#34;                  &#34;                        
&#34;          5,8-di-Cl &#34;  &#34;     &#34;                  &#34;                        
&#34;          None      &#34;  &#34;     &#34;                  Na.sup.+                 
&#34;          5-OCH.sub.3, 8-CH.sub.3                                        
                     CH.sub.3                                             
                        &#34;     &#34;                  &#34;                        
&#34;          7-NHCHO   &#34;  &#34;     &#34;                  &#34;                        
&#34;          7-NHCOCH.sub.3                                                 
                     &#34;  &#34;     &#34;                  &#34;                        
&#34;          7-NHCOCH.sub.2 OCH.sub.3                                       
                     &#34;  &#34;     &#34;                  &#34;                        
&#34;          7-NHCOOC.sub.2 H.sub.5                                         
                     &#34;  &#34;     &#34;                  &#34;                        
&#34;          7-NHCOC.sub.6 H.sub.5                                          
                     &#34;  &#34;     &#34;                  &#34;                        
&#34;          7-NHCONHC.sub.2 H.sub.5                                        
                     &#34;  &#34;     &#34;                  K.sup.+                  
&#34;          7-NHCOC.sub.6 H.sub.11                                         
                     &#34;  &#34;     &#34;                  &#34;                        
5-Cl       None      &#34;  &#34;     &#34;                  &#34;                        
&#34;          7-CH.sub.3                                                     
                     H  &#34;     &#34;                  &#34;                        
&#34;          &#34;         &#34;  H     &#34;                  &#34;                        
&#34;          &#34;         &#34;  CH.sub.3                                          
                              &#34;                  &#34;                        
5-Br       &#34;         &#34;  &#34;     &#34;                  &#34;                        
6-SO.sub.2 NH.sub.2                                                       
           &#34;         &#34;  &#34;     &#34;                  &#34;                        
6-SO.sub.2 NHC.sub.2 H.sub.5                                              
           &#34;         &#34;  &#34;     &#34;                  &#34;                        
6-SO.sub.2 N(CH.sub.3).sub.2                                              
           &#34;         &#34;  &#34;     &#34;                  &#34;                        
6-SO.sub.2 N(CH.sub.3 C.sub.2 H.sub.4 OH                                  
           7-OCH.sub.3                                                    
                     &#34;  &#34;     &#34;                  &#34;                        
6-SO.sub.2 NHC.sub.3 H.sub.6 OCH.sub.3                                    
           7-CH.sub.3                                                     
                     &#34;  &#34;     &#34;                  &#34;                        
6-OCH.sub.3                                                               
           &#34;         &#34;  &#34;     &#34;                  &#34;                        
&#34;          &#34;         &#34;  &#34;     &#34;                  &#34;                        
&#34;          &#34;         &#34;  &#34;     &#34;                  &#34;                        
5-Cl       &#34;         &#34;  &#34;     &#34;                  &#34;                        
&#34;          &#34;         &#34;  &#34;     &#34;                  &#34;                        
&#34;          None      &#34;  &#34;     &#34;                  &#34;                        
&#34;          &#34;         &#34;  &#34;     &#34;                  &#34;                        
&#34;          &#34;         &#34;  &#34;     &#34;                  &#34;                        
&#34;          &#34;         &#34;  &#34;     &#34;                  &#34;                        
&#34;          7-CH.sub.3                                                     
                     &#34;  &#34;     &#34;                  &#34;                        
&#34;          &#34;         &#34;  &#34;     &#34;                  &#34;                        
None       &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2        
                                                 &#34;                        
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2        
                                                 &#34;                        
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2         
                                                 &#34;H.sub.2                 
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.sub
                              .2 CH.sub.2        &#34;                        
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2       
                              CH.sub.2           &#34;                        
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.2     
                                                 &#34;                        
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2     
                                                 &#34;                        
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 N(COC.sub.6 H.sub.5)CH.sub
                              .2 CH.sub.2        &#34;                        
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 (CH.sub.3)                
                                                 &#34;                        
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2           
                                                 Na.sup.+                 
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH(CH.sub.2 Cl)                    
                                                 &#34;                        
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH(CH.sub.2 OCH.sub.3)             
                                                 &#34;                        
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH(C.sub.6 H.sub.5)                
                                                 &#34;                        
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)      
                                                 &#34;                        
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3)SO.sub
                              .2 CH.sub.2 CH.sub.2                        
                                                 &#34;                        
&#34;          &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2                  
                                                 &#34;                        
__________________________________________________________________________
 
    
     
                                           TABLE 6                                 
__________________________________________________________________________
 ##STR22##                                                                
Substituents on                                                           
Ring B     (R.sub.1).sub.m                                                
                     R.sub.3                                              
                         Z                 M                              
__________________________________________________________________________
None       None      H   CH.sub.2 CH.sub.2 Na.sup.+                       
&#34;          6-CH.sub.3                                                     
                     &#34;   &#34;                 &#34;                              
6-CH.sub.3 &#34;         3-CH.sub.3                                           
                         &#34;                 &#34;                              
&#34;          6-OCH.sub.3                                                    
                     &#34;   &#34;                 &#34;                              
None       &#34;         H   &#34;                 &#34;                              
&#34;          6-CH.sub.3                                                     
                     3-CH.sub.3                                           
                         CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2              
                                           &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
&#34;          6-NHCOCH.sub.3                                                 
                     &#34;   &#34;                 K.sup.+                        
&#34;          6-NHCOC.sub.6 H.sub.5                                          
                     &#34;   &#34;                 &#34;                              
&#34;          6-NHCOC.sub.4 H.sub.9 -n                                       
                     &#34;   &#34;                 &#34;                              
&#34;          6-NHCONHC.sub.2 H.sub.5                                        
                     &#34;   &#34;                 &#34;                              
5-Br       6-NHCOCH.sub.2 OCH.sub.3                                       
                     &#34;   &#34;                 &#34;                              
6-OCH.sub.3                                                               
           6-NHCOCH.sub.2 CN                                              
                     &#34;   &#34;                 &#34;                              
6-SO.sub.2 NH.sub.2                                                       
           6-CH.sub.3                                                     
                     &#34;   &#34;                 Na.sup.+                       
6-SO.sub.2 NHC.sub.4 H.sub.9 -n                                           
           &#34;         &#34;   &#34;                 &#34;                              
6-SO.sub.2 NHC.sub.3 H.sub.6 OCH.sub.3                                    
           &#34;         &#34;   &#34;                 &#34;                              
6-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                       
           &#34;         &#34;   &#34;                 &#34;                              
6-SO.sub.2 N(C.sub.2 H.sub. 4 OH).sub.2                                   
           &#34;         &#34;   &#34;                 &#34;                              
6-SO.sub.2 NHC.sub.6 H.sub.11                                             
           &#34;         &#34;   &#34;                 &#34;                              
6-SO.sub.2 N(CH.sub.3)C.sub.2 H.sub.4 OH                                  
           &#34;         &#34;   &#34;                 &#34;                              
5-Cl       &#34;         &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
&#34;          6-NHCHO   &#34;   &#34;                 &#34;                              
&#34;          6-CH.sub.3                                                     
                     &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
None       &#34;         &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   &#34;                 &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH(CH.sub.3)                            
                                           &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH(C.sub.6 H.sub.5)                     
                                           &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH(CH.sub.2 Cl)                         
                                           &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH(OSO.sub.3 K)CH.sub.2                 
                                           &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)           
                                           &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2             
                                           &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2             
                                           &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2 CH.sub.2     
                                           &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.sub.2   
                         CH.sub.2          &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 N(SO.sub.2 C.sub.6 H.sub.5)CH.s
                         ub.2 CH.sub.2     &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 SO.sub.2 N(CH.sub.3)CH.sub.2   
                         CH.sub.2          &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 NHCOCH.sub.2                   
                                           &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.2   
                         CH.sub.2          &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2          
                                           &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2 CH.sub.2 
                         CH.sub.2          &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 SO.sub.2 N(C.sub.6 H.sub.5)CH.s
                         ub.2 CH.sub.2     &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 NHCONHCH.sub.2 CH.sub.2        
                                           &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 CH.sub.2                       
                                           &#34;                              
&#34;          &#34;         &#34;   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2SCH.sub.2     
                         CH.sub.2          &#34;                              
__________________________________________________________________________
 
    
     
                                           TABLE 7                                 
__________________________________________________________________________
 ##STR23##                                                                
Substituents on                                                           
Ring C       (R.sub.1).sub.m                                              
                        R.sub.2      Z                M                   
__________________________________________________________________________
5-CH.sub.3   None       C.sub.2 H.sub.5                                   
                                     CH.sub.2 CH.sub.2                    
                                                      K.sup.+             
5-CH.sub.2 CH.sub.3                                                       
             &#34;          C.sub.6 H.sub.11                                  
                                     &#34;                &#34;                   
5-CH.sub.2 CH(CH.sub.3)                                                   
             &#34;          C.sub.6 H.sub.5                                   
                                     &#34;                &#34;                   
5-C.sub.6 H.sub.5                                                         
             3-CH.sub.3 C.sub.2 H.sub.5                                   
                                     &#34;                &#34;                   
5-C.sub.6 H.sub.11                                                        
             &#34;          CH.sub.2 C.sub.6 H.sub.5                          
                                     &#34;                &#34;                   
5-C.sub.6 H.sub.4 -p-Cl                                                   
             &#34;          CH.sub.2 CH.sub.2 OCH.sub.3                       
                                     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2  
                                                      &#34;                   
5-C.sub.6 H.sub.4OCH.sub.3                                                
             &#34;          CH.sub.2 CH.sub.2 CONH.sub.2                      
                                     CH.sub.2 CH.sub.2                    
                                                      &#34;                   
5-C.sub.6 H.sub.4 -m-OCH.sub. 3                                           
             &#34;          CH.sub.2 CH.sub.2 Cl                              
                                     &#34;                &#34;                   
5-SCH.sub.3  3-NHCOCH.sub.3                                               
                        C.sub.2 H.sub.5                                   
                                     &#34;                &#34;                   
&#34;            2-CH.sub.3 -5-NHCOCH.sub.3                                   
                        H            &#34;                &#34;                   
&#34;            2-OCH.sub.3 -5-CH.sub.3                                      
                        &#34;            &#34;                &#34;                   
&#34;            2-Cl       &#34;            &#34;                &#34;                   
&#34;            2-CH.sub.3 &#34;            &#34;                &#34;                   
&#34;            2,5-di-Cl  &#34;            &#34;                &#34;                   
&#34;            2-OCH.sub.3 -5-Cl                                            
                        &#34;            &#34;                &#34;                   
&#34;            2-OCH.sub.3 -5-CH.sub.3                                      
                        &#34;            &#34;                &#34;                   
5-OC.sub.2 H.sub.5                                                        
             2,5-di-CH.sub.3                                              
                        &#34;            &#34;                Na.sup.+            
5-SC.sub.2 H.sub.5                                                        
             3-CH.sub.3                                                   
                         ##STR24##   &#34;                &#34;                   
&#34;            3-CH.sub.3                                                   
                         ##STR25##   CH.sub.2 CH(CH.sub.2 Cl)             
                                                      &#34;                   
&#34;            3-CH.sub.3                                                   
                         ##STR26##   CH.sub.2 CH.sub.2                    
                                                      NH.sub.4.sup.+      
&#34;            3-CH.sub.3                                                   
                         ##STR27##   &#34;                K.sup.+             
&#34;            3-CH.sub.3 CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3             
                                     &#34;                &#34;                   
&#34;            3-CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3           
                                     &#34;                &#34;                   
&#34;            None       CH.sub.3     CH.sub.2 CH.sub.2                    
                                                      &#34;                   
5-Cl         3-CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2                       
                                     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 
                                                      &#34;                   
5-SO.sub.2 CH.sub.3                                                       
             &#34;          CH.sub.2 C.sub.6 H.sub.11                         
                                     CH.sub.2 CH.sub.2                    
                                                      &#34;                   
5-OC.sub.4 H.sub.9 -n                                                     
             &#34;          CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                
                                     &#34;                &#34;                   
5-SCH.sub.2 CH.sub.2 OH                                                   
             &#34;          CH(CH.sub.3).sub.2                                
                                     &#34;                &#34;                   
5-SCH.sub.2 CH.sub.2 COOCH.sub.3                                          
             H          CH.sub.2 CH.sub.3                                 
                                     &#34;                K.sup.+             
 ##STR28##   &#34;          CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2     
                        H.sub.5      &#34;                &#34;                   
5-SCH.sub.2 SC.sub.6 H.sub.5                                              
             3-CH.sub.3 CH.sub.2 CH.sub.3                                 
                                     &#34;                &#34;                   
5-SO.sub.2 CH.sub.3                                                       
             &#34;          &#34;            &#34;                &#34;                   
5-SO.sub.2 NH.sub.2                                                       
             &#34;          &#34;            &#34;                &#34;                   
5-SO.sub.2 NHC.sub.2 H.sub.5                                              
             &#34;          &#34;            &#34;                &#34;                   
5-SCN        3-NHCOC.sub.6 H.sub.5                                        
                        &#34;            &#34;                &#34;                   
5-SO.sub.2 N(CH.sub.3).sub.2                                              
             3-NHCONC.sub.2 H.sub.5                                       
                        &#34;            &#34;                &#34;                   
5-SO.sub.3 (C.sub.6 H.sub.5)                                              
             3-NHCOCH.sub.2 OCH.sub.3                                     
                        &#34;            &#34;                &#34;                   
5-SCH.sub.3 CHCH.sub.2                                                    
             3-NHCOC.sub.6 H.sub.11                                       
                        &#34;            &#34;                &#34;                   
5-SCH.sub.2 CH.sub.2 OCH.sub.3                                            
             3-NHCOOC.sub.2 H.sub.5                                       
                        &#34;            CH.sub.2 CH(CH.sub.3)                
                                                      &#34;                   
 ##STR29##   3-NHCOCH.sub.2 CN                                            
                        &#34;            CH.sub.2 CH(CH.sub.2 OCH.sub.3)      
                                                      &#34;                   
5-SC.sub.6 H.sub.11                                                       
             &#34;          &#34;            CH.sub.2 CH.sub.2                    
                                                      &#34;                   
5-SC.sub.6 H.sub.5                                                        
             None       &#34;            &#34;                &#34;                   
5-SO.sub.2 C.sub.6 H.sub.5                                                
             &#34;          &#34;            &#34;                                    
5-I          3-CH.sub.3 &#34;            CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 
                                                      &#34;                   
5-Br         &#34;          &#34;            CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2  
                                     CH.sub.2 CH.sub.2 CH.sub.2           
                                                      &#34;                   
 ##STR30##   &#34;          &#34;            CH.sub.2 CH.sub.2 N(SO.sub.2         
                                     CH.sub.3)CH.sub.2 CH.sub.2           
                                                      &#34;                   
5-SCH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                  
             &#34;          &#34;            CH.sub.2 CH.sub.2 N(COCH.sub.3)CH.sub
                                     .2 CH.sub.2      &#34;                   
5-SCH.sub.2 CH.sub.2 NHCOCH.sub.3                                         
             &#34;          &#34;            CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2
                                      CH.sub.2        &#34;                   
5-SCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                     
             &#34;          &#34;            CH.sub.2 CH.sub.2                    
                                                      &#34;                   
5-SCH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                      
             &#34;          &#34;            &#34;                &#34;                   
5-SCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                     
             &#34;          &#34;            CH.sub.2 CH.sub.2 CONHC.sub.2        
                                                      &#34;.sub.4             
5-SO.sub.2 C.sub.6 H.sub.11                                               
             &#34;          &#34;            CH.sub.2 CH.sub.2 NHCOCH.sub.2       
                                                      &#34;                   
5-CH.sub.3   &#34;          &#34;            CH.sub.2 CH.sub.2 NHSO.sub.2         
                                     CH.sub.2 CH.sub.2                    
                                                      &#34;                   
&#34;            3-NHCOC.sub.6 H.sub.5                                        
                        &#34;            CH.sub.2 CH.sub.2                    
                                                      &#34;                   
&#34;            3-NHCOOC.sub.2 H.sub.5                                       
                        &#34;            &#34;                &#34;                   
5-NHCOCH.sub.3                                                            
             3-CH.sub.3 CH.sub.2 CH.sub.2 OSO.sub.3 Na                    
                                     &#34;                Na.sup.+            
&#34;            &#34;          C.sub.2 H.sub.5                                   
                                     CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2    
                                                      &#34;                   
__________________________________________________________________________
 
    
     
                                           TABLE 8                                 
__________________________________________________________________________
 ##STR31##                                                                
Substituents on                                                           
Ring C       (R.sub.1).sub.m                                              
                       R.sub.3                                            
                          R.sub.4                                         
                                Z                  M                      
__________________________________________________________________________
None         None      CH.sub.3                                           
                          CH.sub.3                                        
                                CH.sub.2 CH.sub.2  K.sup.+                
&#34;            &#34;         H  CH.sub.3                                        
                                &#34;                  &#34;                      
&#34;            7-CH.sub.3                                                   
                       &#34;  &#34;     &#34;                  &#34;                      
5-CH.sub.3   &#34;         CH.sub.3                                           
                          &#34;     &#34;                  &#34;                      
5-CH.sub.2 CH.sub.3                                                       
             7-CH.sub.3                                                   
                       H  CH(CH.sub.3).sub.2                              
                                &#34;                  &#34;                      
5-CH(CH.sub.3).sub.2                                                      
             7-OCH.sub.3                                                  
                       &#34;  CH.sub.3                                        
                                &#34;                  &#34;                      
5-CH.sub. 2 CH(CH.sub.3).sub.2                                            
             5-OCH.sub.3, 8-CH.sub.3                                      
                       &#34;  &#34;     &#34;                  &#34;                      
5-C.sub.6 H.sub.5                                                         
             5,8-di-OCH.sub.3                                             
                       &#34;  &#34;     &#34;                  &#34;                      
5-C.sub.6 H.sub.11                                                        
             5,8-di-CH.sub.3                                              
                       &#34;  &#34;     &#34;                  &#34;                      
5-C.sub.6 H.sub.4 -o-Cl                                                   
             7-Cl      &#34;  &#34;     &#34;                  &#34;                      
5-C.sub.6 H.sub.4 -m-CH.sub. 3                                            
             5,8-di-Cl &#34;  &#34;     &#34;                  &#34;                      
5-C.sub.6 H.sub.4 -p-OCH.sub. 3                                           
             None      &#34;  &#34;     &#34;                  Na.sup.+               
5-OC.sub.2 H.sub.5                                                        
             5-OCH.sub.3, 8-CH.sub.3                                      
                       CH.sub.3                                           
                          &#34;     &#34;                  &#34;                      
&#34;            7-NHCHO   &#34;  &#34;     &#34;                  &#34;                      
&#34;            7-NHCOCH.sub.3                                               
                       &#34;  &#34;     &#34;                  &#34;                      
&#34;            7-NHCOCH.sub.2 OCH.sub.3                                     
                       &#34;  &#34;     &#34;                  &#34;                      
&#34;            7-NHCOOC.sub.2 H.sub.5                                       
                       &#34;  &#34;     &#34;                  &#34;                      
&#34;            7-NHCOC.sub.6 H.sub.5                                        
                       &#34;  &#34;     &#34;                  &#34;                      
&#34;            7-NHCONHC.sub.2 H.sub.5                                      
                       &#34;  &#34;     &#34;                  K.sup.+                
5-Cl         7-NHCOC.sub.6 H.sub.11                                       
                       &#34;  &#34;     &#34;                  &#34;                      
&#34;            None      &#34;  &#34;     &#34;                  &#34;                      
&#34;            7-CH.sub.3                                                   
                       H  &#34;     &#34;                  &#34;                      
&#34;            &#34;         &#34;  H     &#34;                  &#34;                      
5-I          &#34;         &#34;  CH.sub.3                                        
                                &#34;                  &#34;                      
5-Br         &#34;         &#34;  &#34;     &#34;                  &#34;                      
5-SO.sub.2 CH.sub.3                                                       
             &#34;         &#34;  &#34;     &#34;                  &#34;                      
5-SO.sub.2 NH.sub.2                                                       
             &#34;         &#34;  &#34;     &#34;                  &#34;                      
5-SO.sub.2 N(CH.sub.3).sub.2                                              
             &#34;         &#34;  &#34;     &#34;                  &#34;                      
5-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                       
             7-OCH.sub.3                                                  
                       &#34;  &#34;     &#34;                  &#34;                      
5-SO.sub.2 NHC.sub.3 H.sub.6 OCH.sub.3                                    
             7-CH.sub.3                                                   
                       &#34;  &#34;     &#34;                  &#34;                      
5-SO.sub.2 CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                             
             &#34;         &#34;  &#34;     &#34;                  &#34;                      
5-SC.sub.6 H.sub.5                                                        
             &#34;         &#34;  &#34;     &#34;                  &#34;                      
5-SC.sub.6 H.sub.11                                                       
             &#34;         &#34;  &#34;     &#34;                  &#34;                      
5-SO.sub.2 C.sub.6 H.sub.5                                                
             &#34;         &#34;  &#34;     &#34;                  &#34;                      
5-SO.sub. 3 C.sub.6 H.sub.5                                               
             &#34;         &#34;  &#34;     &#34;                  &#34;                      
5-SCH.sub.2 CH.sub.2 OH                                                   
             None      &#34;  &#34;     &#34;                  &#34;                      
5-SCH.sub.2 CHCH.sub.2                                                    
             &#34;         &#34;  &#34;     &#34;                  &#34;                      
5-SCH.sub.2 COOC.sub.2 H.sub.5                                            
             &#34;         &#34;  &#34;     &#34;                  &#34;                      
5-SCH.sub.2 C.sub.6 H.sub.5                                               
             &#34;         &#34;  &#34;     &#34;                  &#34;                      
5-SCH.sub.2 C.sub.6 H.sub.11                                              
             7-CH.sub.3                                                   
                       &#34;  &#34;     &#34;                  &#34;                      
5-SCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                     
             &#34;         &#34;  &#34;     &#34;                  &#34;                      
5-SCN        &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2      
                                                   &#34;                      
5-SCH.sub.2 CH.sub.2 NHCOCH.sub.3                                         
             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2      
                                                   &#34;                      
 ##STR32##   &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2       
                                CH.sub.2           &#34;                      
5-SCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                     
             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.s
                                ub.2 CH.sub.2      &#34;                      
5-SCH.sub.2 CH.sub.3                                                      
             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2     
                                CH.sub.2           &#34;                      
&#34;            &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.2   
                                                   &#34;                      
&#34;            &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2   
                                                   &#34;                      
&#34;            &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 N(COC.sub.6 H.sub.5)CH.s
                                ub.2 CH.sub.2      &#34;                      
&#34;            &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 (CH.sub.3)              
                                                   &#34;                      
&#34;            &#34;         &#34;  &#34;     CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2         
                                                   Na.sup.+               
&#34;            &#34;         &#34;  &#34;     CH.sub.2 CH(CH.sub.2 Cl)                  
                                                   &#34;                      
5-SCH.sub.3  &#34;         &#34;  &#34;     CH.sub.2 CH(CH.sub.2 OCH.sub.3)           
                                                   &#34;                      
&#34;            &#34;         &#34;  &#34;     CH.sub.2 CH(C.sub.6 H.sub.5)              
                                                   &#34;                      
&#34;            &#34;         &#34;  &#34;     CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)    
                                                   &#34;                      
&#34;            &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3)SO.s
                                ub.2 CH.sub.2 CH.sub.2                    
                                                   &#34;                      
5-NHCOCH.sub.3                                                            
             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2                
                                                   &#34;                      
__________________________________________________________________________
 
    
     
                                           TABLE 9                                 
__________________________________________________________________________
 ##STR33##                                                                
Substituents on                                                           
Ring C        (R.sub.1)m R.sub.3                                          
                              Z                  M                        
__________________________________________________________________________
None          None       H    CH.sub.2 CH.sub.2  Na.sup.+                 
&#34;             6-CH.sub.3 &#34;    &#34;                  &#34;                        
&#34;             &#34;          3-CH.sub.3                                       
                              &#34;                  &#34;                        
5-CH.sub. 3   6-OCH.sub.3                                                 
                         &#34;    &#34;                  &#34;                        
5-CH(CH.sub.3).sub.2                                                      
              &#34;          H    &#34;                  &#34;                        
5-CH.sub.2 CH(CH.sub.3).sub.2                                             
              6-CH.sub.3 3-CH.sub.3                                       
                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         
                                                 &#34;                        
5-C.sub.6 H.sub.5                                                         
              &#34;          &#34;    CH.sub.2 CH.sub.2  &#34;                        
5-C.sub.6 H.sub.4 -p-Cl                                                   
              &#34;          &#34;    &#34;                  &#34;                        
5-C.sub.6 H.sub.4 -p-OCH.sub. 3                                           
              &#34;          &#34;    &#34;                  &#34;                        
5-C.sub.6 H.sub.4 -m-CH.sub. 3                                            
              &#34;          &#34;    &#34;                  &#34;                        
5-OC.sub.2 H.sub.5                                                        
              &#34;          &#34;    &#34;                  &#34;                        
5-OCH(CH.sub.3).sub.2                                                     
              &#34;          &#34;    &#34;                  &#34;                        
5-C.sub.6 H.sub.11                                                        
              &#34;          &#34;    &#34;                  &#34;                        
5-SCN         &#34;          &#34;    &#34;                  &#34;                        
5-SCH.sub.3   6-NHCOCH.sub.3                                              
                         &#34;    &#34;                  K.sup.+                  
5-SCH.sub.2 CH(CH.sub.3).sub.2                                            
              6-NHCOC.sub.6 H.sub.5                                       
                         &#34;    &#34;                  &#34;                        
5-SCH.sub.2 CHCH.sub.2                                                    
              6-NHCOC.sub.4 H.sub.9 -n                                    
                         &#34;    &#34;                  &#34;                        
5-SC.sub.6 H.sub.11                                                       
              6-NHCONHC.sub.2 H.sub.5                                     
                         &#34;    &#34;                  &#34;                        
5-SC.sub.6 H.sub.5                                                        
              6-NHCOCH.sub.2 OCH.sub.3                                    
                         &#34;    &#34;                  &#34;                        
5-SCH.sub.2 C.sub.6 H.sub.5                                               
              6-NHCOCH.sub.2 CN                                           
                         &#34;    &#34;                  &#34;                        
5-SCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                     
              6-CH.sub.3 &#34;    &#34;                  Na.sup.+                 
5-SCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                     
              &#34;          &#34;    &#34;                  &#34;                        
5-SCH.sub.2 CH.sub.2 OH                                                   
              &#34;          &#34;    &#34;                  &#34;                        
5-SCH.sub.2 CH.sub.2 Cl                                                   
              &#34;          &#34;    &#34;                  &#34;                        
5-SCH.sub.2 COOC.sub.2 H.sub.5                                            
              &#34;          &#34;    &#34;                  &#34;                        
5-SCH.sub.2 CH.sub.2 OCOCH.sub.3                                          
              &#34;          &#34;    &#34;                  &#34;                        
5-SCH.sub.2 C.sub.6 H.sub.11                                              
              &#34;          &#34;    &#34;                  &#34;                        
5-SO.sub.2 CH.sub.3                                                       
              &#34;          &#34;    &#34;                  &#34;                        
5-SO.sub.2 C.sub.4 H.sub.9 -n                                             
              &#34;          &#34;    &#34;                  &#34;                        
5-SO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                    
              6-NHCHO    &#34;    &#34;                  &#34;                        
5-SO.sub.2 C.sub.6 H.sub.5                                                
              6-CH.sub.3 &#34;    &#34;                  &#34;                        
5-SO.sub.2 C.sub.6 H.sub.11                                               
              &#34;          &#34;    &#34;                  &#34;                        
5-SO.sub.2 CH.sub.2 C.sub.6 H.sub.5                                       
              &#34;          &#34;    &#34;                  &#34;                        
5-SO.sub.2 CH.sub.2 CH.sub.2 OH                                           
              &#34;          &#34;    &#34;                  &#34;                        
 ##STR34##    &#34;          &#34;    &#34;                  &#34;                        
5-SCH.sub.2 CH.sub.2 NHCOCH.sub.3                                         
              &#34;          &#34;    &#34;                  &#34;                        
 ##STR35##    &#34;          &#34;    &#34;                  &#34;                        
5-SO.sub.2 NH.sub.2                                                       
              &#34;          &#34;    &#34;                  &#34;                        
5-SO.sub.2 NHC.sub.3 H.sub.6 OCH.sub.3                                    
              &#34;          &#34;    CH.sub.2 CH(CH.sub.3)                       
                                                 &#34;                        
5-SO.sub.2 N(CH.sub.3).sub.2                                              
              &#34;          &#34;    CH.sub.2 CH(C.sub.6 H.sub.5)                
                                                 &#34;                        
5-SO.sub.2 NHC.sub.2 H.sub.5                                              
              &#34;          &#34;    CH.sub.2 CH(CH.sub.2 Cl)                    
                                                 &#34;                        
5-SO.sub.2 NHC.sub.6 H.sub.11                                             
              &#34;          &#34;    CH.sub.2 CH(OSO.sub.3 K)CH.sub.2            
                                                 &#34;                        
5-SO.sub.3 C.sub.6 H.sub.5                                                
              &#34;          &#34;    CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)      
                                                 &#34;                        
5-SO.sub.2 NHC.sub.6 H.sub.5                                              
              &#34;          &#34;    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2        
                                                 &#34;                        
5-NHCOCH.sub.3                                                            
              &#34;          &#34;    CH.sub.2 CH.sub.2 SCH.sub.2                 
                                                 &#34;H.sub.2                 
5-SC.sub.2 H.sub.5                                                        
              &#34;          &#34;    CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2         
                                                 &#34;H.sub.2                 
&#34;             &#34;          &#34;    CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.sub
                              .2 CH.sub.2        &#34;                        
&#34;             &#34;          &#34;    CH.sub.2 CH.sub.2 N(SO.sub.2 C.sub.6        
                              H.sub.5)CH.sub.2 CH.sub.2                   
                                                 &#34;                        
&#34;             &#34;          &#34;    CH.sub.2 CH.sub.2 SO.sub.2 N(CH.sub.3)CH.sub
                              .2 CH.sub.2        &#34;                        
&#34;             &#34;          &#34;    CH.sub.2 CH.sub.2 NHCOCH.sub.2              
                                                 &#34;                        
&#34;             &#34;          &#34;    CH.sub.2 CH.sub.2 CH.sub.2 NHSO.sub.2       
                              CH.sub.2 CH.sub.2  &#34;                        
&#34;             &#34;          &#34;    CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2     
                                                 &#34;                        
&#34;             &#34;          &#34;    CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2     
                              CH.sub.2 CH.sub.2  &#34;                        
&#34;             &#34;          &#34;    CH.sub.2 CH.sub.2 SO.sub.2 N(C.sub.6        
                              H.sub.5)CH.sub.2 CH.sub.2                   
                                                 &#34;                        
&#34;             &#34;          &#34;    CH.sub.2 CH.sub.2 NHCONHCH.sub.2 CH.sub.2   
                                                 &#34;                        
&#34;             &#34;          &#34;    CH.sub.2 CH.sub.2 CH.sub.2                  
                                                 &#34;                        
&#34;             &#34;          &#34;    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2SCH.sub.2
                               CH.sub.2          &#34;                        
__________________________________________________________________________
 
    
     
                                           TABLE 10                                
__________________________________________________________________________
 ##STR36##                                                                
Substituents on                                                           
Ring D     (R.sub.1)m R.sub.2      Z                M                     
__________________________________________________________________________
3-CH.sub.3 None       C.sub.2 H.sub.5                                     
                                   CH.sub.2 CH.sub.2                      
                                                    K.sup.+               
&#34;          &#34;          C.sub.6 H.sub.11                                    
                                   &#34;                &#34;                     
&#34;          &#34;          C.sub.6 H.sub.5                                     
                                   &#34;                &#34;                     
&#34;          3CH.sub.3  C.sub.2 H.sub.5                                     
                                   &#34;                &#34;                     
&#34;          &#34;          CH.sub.2 C.sub.6 H.sub.5                            
                                   &#34;                &#34;                     
&#34;          &#34;          CH.sub.2 CH.sub.2 OCH.sub.3                         
                                   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2    
                                                    &#34;                     
&#34;          &#34;          CH.sub.2 CH.sub.2 CONH.sub.2                        
                                   CH.sub.2 CH.sub.2                      
                                                    &#34;                     
3-SCH.sub.3                                                               
           &#34;          CH.sub.2 CH.sub.2 Cl                                
                                   &#34;                &#34;                     
3-C.sub.6 H.sub.5                                                         
           3-NHCOCH.sub.3                                                 
                      C.sub.2 H.sub.5                                     
                                   &#34;                &#34;                     
3-C.sub.6 H.sub.4p-Cl                                                     
           2-CH.sub.35-NHCOCH.sub.3                                       
                      H            &#34;                &#34;                     
3-C.sub.6 H.sub.4o-CN                                                     
           2-OCH.sub.35-CH.sub.3                                          
                      &#34;            &#34;                &#34;                     
&#34;          2-Cl       &#34;            &#34;                &#34;                     
&#34;          2-CH.sub.3 &#34;            &#34;                &#34;                     
&#34;          2,5-di-Cl  &#34;            &#34;                &#34;                     
&#34;          2-OCH.sub.35-Cl                                                
                      &#34;            &#34;                &#34;                     
&#34;          2-OCH.sub.35-CH.sub.3                                          
                      &#34;            &#34;                &#34;                     
&#34;          2,5-di-CH.sub.3                                                
                      &#34;            &#34;                &#34;                     
3-C.sub.6 H.sub.5                                                         
           3-CH.sub.3                                                     
                       ##STR37##   &#34;                &#34;                     
&#34;          3-CH.sub.3                                                     
                       ##STR38##   CH.sub.2 CH(CH.sub.2 Cl)               
                                                    &#34;                     
&#34;          3-CH.sub.3                                                     
                       ##STR39##   CH.sub.2 CH.sub.2                      
                                                    NH.sub.4.sup.+        
&#34;          3-CH.sub.3                                                     
                       ##STR40##   &#34;                K.sup.+               
&#34;          3-CH.sub.3 CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3               
                                   &#34;                &#34;                     
3-C.sub.6 H.sub.4p-CH.sub.2                                               
           3-CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3             
                                   &#34;                &#34;                     
3-C.sub.6 H.sub.5                                                         
           None       CH.sub.3     CH.sub.2 CH.sub.2                      
                                                    &#34;                     
&#34;          3-CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2                         
                                   CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2   
                                                    &#34;                     
&#34;          &#34;          CH.sub.2 C.sub.6 H.sub.11                           
                                   CH.sub.2 CH.sub.2                      
                                                    &#34;                     
&#34;          &#34;          CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                  
                                   &#34;                &#34;                     
&#34;          &#34;          CH(CH.sub.3).sub.2                                  
                                   &#34;                &#34;                     
&#34;          H          CH.sub.2 CH.sub.3                                   
                                   &#34;                K.sup.+               
&#34;          &#34;          CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2       
                      H.sub.5      &#34;                &#34;                     
3-SO.sub.2 CH.sub.3                                                       
           3-CH.sub.3 CH.sub.2 CH.sub.3                                   
                                   &#34;                &#34;                     
3-SCH.sub.2 CH.sub.2 COOCH.sub.3                                          
           &#34;          &#34;            &#34;                &#34;                     
3-SCH.sub. 2 C.sub.6 H.sub.5                                              
           &#34;          &#34;            &#34;                &#34;                     
3-SCH.sub.2 CH.sub.2 OCH.sub.3                                            
           &#34;          &#34;            &#34;                &#34;                     
3-SC.sub.6 H.sub.11                                                       
           3-NHCOC.sub.6 H.sub.5                                          
                      &#34;            &#34;                &#34;                     
3-SC.sub.2 H.sub.5                                                        
           3-NHCONHC.sub.2 H.sub.5                                        
                      &#34;            &#34;                &#34;                     
&#34;          3-NHCOCH.sub.2 OCH.sub.3                                       
                      &#34;            &#34;                &#34;                     
&#34;          3-NHCOC.sub.6 H.sub.11                                         
                      &#34;            &#34;                &#34;                     
&#34;          3-NHCOOC.sub.2 H.sub.5                                         
                      &#34;            CH.sub.2 CH(CH.sub.3)                  
                                                    &#34;                     
&#34;          3-NHCOCH.sub.2 CN                                              
                      &#34;            CH.sub.2 CH(CH.sub.2 OCH.sub.3)        
                                                    &#34;                     
3-SCH.sub.2 COOCH.sub.3                                                   
           &#34;          &#34;            CH.sub.2 CH.sub.2                      
                                                    &#34;                     
&#34;          None       &#34;            &#34;                &#34;                     
&#34;          &#34;          &#34;            &#34;                &#34;                     
&#34;          3-CH.sub.3 &#34;            CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2   
                                                    &#34;                     
3-SCH.sub.3                                                               
           &#34;          &#34;            CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2    
                                   CH.sub.2 CH.sub.2 CH.sub.2             
                                                    &#34;                     
&#34;          &#34;          &#34;            CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)C
                                   H.sub.2 CH.sub.2 &#34;                     
&#34;          &#34;          &#34;            CH.sub.2 CH.sub.2 N(COCH.sub.3)CH.sub.2
                                    CH.sub.2        &#34;                     
&#34;          &#34;          &#34;            CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2  
                                   CH.sub.2         &#34;                     
3-SCH.sub.2 CH(CH.sub.3).sub.2                                            
           &#34;          &#34;            CH.sub.2 CH.sub.2                      
                                                    &#34;                     
&#34;          &#34;          &#34;            &#34;                &#34;                     
&#34;          &#34;          &#34;            CH.sub.2 CH.sub.2 CONHC.sub.2 H.sub.4  
                                                    &#34;                     
&#34;          &#34;          &#34;            CH.sub.2 CH.sub.2 NHCOCH.sub.2         
                                                    &#34;                     
&#34;          &#34;          &#34;            CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.2  
                                   CH.sub.2         &#34;                     
&#34;          3-NHCOC.sub.6 H.sub.5                                          
                      &#34;            CH.sub.2 CH.sub.2                      
                                                    &#34;                     
&#34;          3-NHCOOC.sub.2 H.sub.5                                         
                      &#34;            &#34;                &#34;                     
&#34;          3-CH.sub.3 CH.sub.2 CH.sub.2 OSO.sub.3 Na                      
                                   &#34;                Na.sup.+              
&#34;          &#34;          C.sub.2 H.sub.5                                     
                                   CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2      
                                                    &#34;                     
__________________________________________________________________________
 
    
     
                                           TABLE 11                                
__________________________________________________________________________
 ##STR41##                                                                
Substituents on                                                           
Ring D        (R.sub.1).sub.m                                             
                        R.sub.3                                           
                           R.sub.4                                        
                                 Z                  M                     
__________________________________________________________________________
3-CH.sub.3    None      CH.sub.3                                          
                           CH.sub.3                                       
                                 CH.sub.2 CH.sub.2  K.sup.+               
&#34;             &#34;         H  CH.sub.3                                       
                                 &#34;                  &#34;                     
&#34;             7-CH.sub.3                                                  
                        &#34;  &#34;     &#34;                  &#34;                     
&#34;             &#34;         CH.sub.3                                          
                           &#34;     &#34;                  &#34;                     
&#34;             7-CH.sub.3                                                  
                        H  CH(CH.sub.3).sub.2                             
                                 &#34;                  &#34;                     
&#34;             7-OCH.sub.3                                                 
                        &#34;  CH.sub.3                                       
                                 &#34;                  &#34;                     
&#34;             5-OCH.sub.3, 8-CH.sub.3                                     
                        &#34;  &#34;     &#34;                  &#34;                     
&#34;             5,8-di-OCH.sub.3                                            
                        &#34;  &#34;     &#34;                  &#34;                     
&#34;             5,8-di-CH.sub.3                                             
                        &#34;  &#34;     &#34;                  &#34;                     
&#34;             7-Cl      &#34;  &#34;     &#34;                  &#34;                     
3-SCH.sub.3   5,8-di-Cl &#34;  &#34;     &#34;                  &#34;                     
3-C.sub.6 H.sub.5                                                         
              None      &#34;  &#34;     &#34;                  Na.sup.+              
&#34;             5-OCH.sub.3, 8-CH.sub.3                                     
                        CH.sub.3                                          
                           &#34;     &#34;                  &#34;                     
&#34;             7-NHCHO   &#34;  &#34;     &#34;                  &#34;                     
&#34;             7-NHCOCH.sub.3                                              
                        &#34;  &#34;     &#34;                  &#34;                     
&#34;             7-NHCOCH.sub.2 OCH.sub.3                                    
                        &#34;  &#34;     &#34;                  &#34;                     
&#34;             7-NHCOOC.sub.2 H.sub.5                                      
                        &#34;  &#34;     &#34;                  &#34;                     
&#34;             7-NHCOC.sub.6 H.sub.5                                       
                        &#34;  &#34;     &#34;                  &#34;                     
&#34;             7-NHCONHC.sub.2 H.sub.5                                     
                        &#34;  &#34;     &#34;                  K.sup.+               
&#34;             7-NHCOC.sub.6 H.sub.11                                      
                        &#34;  &#34;     &#34;                  &#34;                     
&#34;             None      &#34;  &#34;     &#34;                  &#34;                     
&#34;             7-CH.sub.3                                                  
                        H  &#34;     &#34;                  &#34;                     
C.sub.6 H.sub.4o-CN                                                       
              &#34;         &#34;  H     &#34;                  &#34;                     
&#34;             &#34;         &#34;  CH.sub.3                                       
                                 &#34;                  &#34;                     
&#34;             &#34;         &#34;  &#34;     &#34;                  &#34;                     
&#34;             &#34;         &#34;  &#34;     &#34;                  &#34;                     
3-C.sub.6 H.sub.4p-CH.sub.3                                               
              &#34;         &#34;  &#34;     &#34;                  &#34;                     
3-C.sub.6 H.sub.4o-Cl                                                     
              &#34;         &#34;  &#34;     &#34;                  &#34;                     
3-SO.sub.2 CH.sub.3                                                       
              7-OCH.sub.3                                                 
                        &#34;  &#34;     &#34;                  &#34;                     
3-SC.sub.6 H.sub.11                                                       
              7-CH.sub.3                                                  
                        &#34;  &#34;     &#34;                  &#34;                     
3-SCH.sub.2 CH.sub.2 OCH.sub.3                                            
              &#34;         &#34;  &#34;     &#34;                  &#34;                     
3-SCH.sub.2 CH.sub.2 COOCH.sub.3                                          
              &#34;         &#34;  &#34;     &#34;                  &#34;                     
3-SCH.sub.2 C.sub.6 H.sub.5                                               
              &#34;         &#34;  &#34;     &#34;                  &#34;                     
3-CH.sub.2 CH.sub.3                                                       
              &#34;         &#34;  &#34;     &#34;                  &#34;                     
3-SCH.sub.2 COOCH.sub.3                                                   
              &#34;         &#34;  &#34;     &#34;                  &#34;                     
3-SCH.sub.2 CH.sub.2 COOC.sub.2 H.sub.5                                   
              None      &#34;  &#34;     &#34;                  &#34;                     
3-SCH.sub.2 CH.sub.2 COOCH(CH.sub.3).sub.2                                
              &#34;         &#34;  &#34;     &#34;                  &#34;                     
3-SO.sub.2 C.sub.4 H.sub.9 -n                                             
              &#34;         &#34;  &#34;     &#34;                  &#34;                     
3-SCH.sub.2 CH.sub.2 CONHC.sub.4 H.sub.9 -n                               
              &#34;         &#34;  &#34;     &#34;                  &#34;                     
3-SCH.sub.3   7-CH.sub.3                                                  
                        &#34;  &#34;     &#34;                  &#34;                     
&#34;             &#34;         &#34;  &#34;     &#34;                  &#34;                     
3-SC.sub.2 H.sub.5                                                        
              &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     
                                                    &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2     
                                                    &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2      
                                 CH.sub.2           &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.
                                 sub.2 CH.sub.2     &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2    
                                 CH.sub.2           &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.2  
                                                    &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2  
                                                    &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 N(COC.sub.6 H.sub.5)CH.
                                 sub.2 CH.sub.2     &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 (CH.sub.3)             
                                                    &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2        
                                                    Na.sup.+              
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH(CH.sub.2 Cl)                 
                                                    &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH(CH.sub.2 OCH.sub.3)          
                                                    &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH(C.sub.6 H.sub.5)             
                                                    &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)   
                                                    &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3)SO.
                                 sub.2 CH.sub.2 CH.sub.2                  
                                                    &#34;                     
&#34;             &#34;         &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2               
                                                    &#34;                     
__________________________________________________________________________
 
    
     
                                           TABLE 12                                
__________________________________________________________________________
 ##STR42##                                                                
Substituents on                                                           
Ring D        (R.sub.1)m                                                  
                        R.sub.3                                           
                            Z                  M                          
__________________________________________________________________________
3-CH.sub.3    None      H   CH.sub.2 CH.sub.2  Na.sup.+                   
&#34;             6-CH.sub.3                                                  
                        &#34;   &#34;                  &#34;                          
&#34;             &#34;         3-CH.sub.3                                        
                            &#34;                  &#34;                          
&#34;             6-OCH.sub.3                                                 
                        &#34;   &#34;                  &#34;                          
&#34;             &#34;         H   &#34;                  &#34;                          
&#34;             6-CH.sub.3                                                  
                        3-CH.sub.3                                        
                            CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2           
                                               &#34;                          
3-SCH.sub.3   &#34;         &#34;   CH.sub.2 CH.sub.2  &#34;                          
3-CH.sub.2 CH.sub.3                                                       
              &#34;         &#34;   &#34;                  &#34;                          
3-SCH.sub.2 CH.sub.2 OCH.sub.3                                            
              &#34;         &#34;   &#34;                  &#34;                          
3-SCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                     
              &#34;         &#34;   &#34;                  &#34;                          
3-SCH.sub.2 CH.sub.2 COOCH.sub.3                                          
              &#34;         &#34;   &#34;                  &#34;                          
3-SCH.sub.2 COOCH.sub.2 CH.sub.3                                          
              &#34;         &#34;   &#34;                  &#34;                          
3-SCH.sub.2 C.sub.6 H.sub.5                                               
              &#34;         &#34;   &#34;                  &#34;                          
3-SC.sub.6 H.sub.11                                                       
              &#34;         &#34;   &#34;                  &#34;                          
3-SCH.sub.3   6-NHCOCH.sub.3                                              
                        &#34;   &#34;                  K.sup.+                    
&#34;             6-NHCOC.sub.6 H.sub.5                                       
                        &#34;   &#34;                  &#34;                          
&#34;             6-NHCOC.sub.4 H.sub.9n                                      
                        &#34;   &#34;                  &#34;                          
&#34;             6-NHCONHC.sub.2 H.sub.5                                     
                        &#34;   &#34;                  &#34;                          
&#34;             6-NHCOCH.sub.2 OCH.sub.3                                    
                        &#34;   &#34;                  &#34;                          
&#34;             6-NHCOCH.sub.2 CN                                           
                        &#34;   &#34;                  &#34;                          
3-SO.sub.2 CH.sub.3                                                       
              6-CH.sub.3                                                  
                        &#34;   &#34;                  Na.sup.+                   
3-SO.sub.2 C.sub.4 H.sub.9n                                               
              &#34;         &#34;   &#34;                  &#34;                          
3-C.sub.6 H.sub.5                                                         
              &#34;         &#34;   &#34;                  &#34;                          
3-C.sub.6 H.sub.4o-CN                                                     
              &#34;         &#34;   &#34;                  &#34;                          
3-C.sub.6 H.sub.4o-Cl                                                     
              &#34;         &#34;   &#34;                  &#34;                          
3-C.sub.6 H.sub.4p-CH.sub.3                                               
              &#34;         &#34;   &#34;                  &#34;                          
3-C.sub.6 H.sub.4m-CH.sub.3                                               
              &#34;         &#34;   &#34;                  &#34;                          
3-C.sub.6 H.sub.4o-CH.sub.3                                               
              &#34;         &#34;   &#34;                  &#34;                          
3-C.sub.6 H.sub.4o-CONH.sub.2                                             
              &#34;         &#34;   &#34;                  &#34;                          
3-C.sub.6 H.sub.4OCN                                                      
              6-NHCHO   &#34;   &#34;                  &#34;                          
3-SCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                     
              6-CH.sub.3                                                  
                        &#34;   &#34;                  &#34;                          
3-SO.sub.2 C.sub.4 H.sub.9 -n                                             
              &#34;         &#34;   &#34;                  &#34;                          
3-SO.sub.2 CH.sub.2 CH.sub.2 COOCH.sub.3                                  
              &#34;         &#34;   &#34;                  &#34;                          
3-SO.sub.2 CH.sub.2 COOCH.sub.3                                           
              &#34;         &#34;   &#34;                  &#34;                          
3-SO.sub.2 C.sub.6 H.sub.11                                               
              &#34;         &#34;   &#34;                  &#34;                          
3-SO.sub.2 CH.sub.2 CH.sub.3                                              
              &#34;         &#34;   &#34;                  &#34;                          
3-SO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                    
              &#34;         &#34;   &#34;                  &#34;                          
3-SCH.sub.2 CH.sub.2 CONHC.sub.2 H.sub.4 OH                               
              &#34;         &#34;   &#34;                  &#34;                          
3-SCH.sub.2 CH.sub.3                                                      
              &#34;         &#34;   CH.sub.2 CH(CH.sub.3)                         
                                               &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH(C.sub.6 H.sub.5)                  
                                               &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH(CH.sub.2 Cl)                      
                                               &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH(OSO.sub.3 K)CH.sub.2              
                                               &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)        
                                               &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2          
                                               &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2          
                                               &#34;                          
3-C.sub.6 H.sub.5                                                         
              &#34;         &#34;   CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2 CH.sub.2  
                                               &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.sub.2
                             CH.sub.2          &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH.sub.2 N(SO.sub.2 C.sub.6 H.sub.5)C
                            H.sub.2 CH.sub.2   &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH.sub.2 SO.sub.2 N(CH.sub.3)CH.sub.2
                             CH.sub.2          &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH.sub.2 NHCOCH.sub.2                
                                               &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH.sub.2 CH.sub.2 NHSO.sub.2         
                            CH.sub.2 CH.sub.2  &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2       
                                               &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2       
                            CH.sub.2 CH.sub.2  &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH.sub.2 SO.sub.2 N(C.sub.6 H.sub.5)C
                            H.sub.2 CH.sub.2   &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH.sub.2 NHCONHCH.sub.2 CH.sub.2     
                                               &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH.sub.2 CH.sub.2                    
                                               &#34;                          
&#34;             &#34;         &#34;   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2SCH.sub.2  
                            CH.sub.2           &#34;                          
__________________________________________________________________________
 
    
     
                                           TABLE 13                                
__________________________________________________________________________
 ##STR43##                                                                
Substituents on                                                           
Ring E          (R.sub.1)m                                                
                          R.sub.2        Z                 M              
__________________________________________________________________________
3-CH.sub.34-Br  None      C.sub.2 H.sub.5                                 
                                         CH.sub.2 CH.sub.2 K.sup.+        
&#34;               &#34;         C.sub.6 H.sub.11                                
                                         &#34;                 &#34;              
&#34;               &#34;         C.sub.6 H.sub.5                                 
                                         &#34;                 &#34;              
&#34;               3CH.sub.3 C.sub.2 H.sub.5                                 
                                         &#34;                 &#34;              
&#34;               &#34;         CH.sub.2 C.sub.6 H.sub.5                        
                                         &#34;                 &#34;              
&#34;               &#34;         CH.sub.2 CH.sub.2 OCH.sub.3                     
                                         CH.sub.2 CH.sub.2 CH.sub.2       
                                         CH.sub.2          &#34;              
&#34;               &#34;         CH.sub.2 CH.sub.2 CONH.sub.2                    
                                         CH.sub.2 CH.sub.2 &#34;              
&#34;               &#34;         CH.sub.2 CH.sub.2 Cl                            
                                         &#34;                 &#34;              
&#34;               3-NHCOCH.sub.3                                            
                          C.sub.2 H.sub.5                                 
                                         &#34;                 &#34;              
&#34;               2-CH.sub.35-NHCOCH.sub.3                                  
                          H              &#34;                 &#34;              
&#34;               2-OCH.sub.35-.sub.3                                       
                          &#34;              &#34;                 &#34;              
&#34;               2-Cl      &#34;              &#34;                 &#34;              
&#34;               2-CH.sub.3                                                
                          &#34;              &#34;                 &#34;              
&#34;               2,5-di-Cl &#34;              &#34;                 &#34;              
&#34;               2-OCH.sub.3 -5-Cl                                         
                          &#34;              &#34;                 &#34;              
3-CH.sub.3 -4-Cl                                                          
                2-OCH.sub.35-CH.sub.3                                     
                          &#34;              &#34;                 &#34;              
&#34;               2,5-di-CH.sub.3                                           
                          &#34;              &#34;                 Na.sup.+       
&#34;               3-CH.sub.3                                                
                           ##STR44##     &#34;                 &#34;              
&#34;               3-CH.sub.3                                                
                           ##STR45##     CH.sub.2 CH(CH.sub.2 Cl)         
                                                           &#34;              
3-CH.sub.34-CN  3-CH.sub.3                                                
                           ##STR46##     CH.sub.2 CH.sub.2 NH.sub.4.sup.+ 
3-CH.sub.34-COOC.sub.2 H.sub.5                                            
                3-CH.sub.3                                                
                           ##STR47##     &#34;                 K.sup.+        
&#34;               3-CH.sub.3                                                
                          CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3           
                                         &#34;                 &#34;              
&#34;               3-CH.sub.3                                                
                          CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3         
                                         &#34;                 &#34;              
&#34;               None      CH.sub.3       CH.sub.2 CH.sub.2 &#34;              
3-CH.sub.34-SCH.sub.2 CHCH.sub.2                                          
                3-CH.sub.3                                                
                          CH.sub.2 CH(CH.sub.3).sub.2                     
                                         CH.sub.2 CH.sub.2 OCH.sub.2      
                                                           &#34;H             
&#34;               &#34;         CH.sub.2 C.sub.6 H.sub.11                       
                                         CH.sub.2 CH.sub.2 &#34;              
&#34;               &#34;         CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5              
                                         &#34;                 &#34;              
3-CH.sub.34-SO.sub.2 C.sub.2 H.sub.5                                      
                &#34;         CH(CH.sub.3).sub.2                              
                                         &#34;                 &#34;              
3-CH.sub.34-SC.sub.6 H.sub.11                                             
                H         CH.sub.2 CH.sub.3                               
                                         &#34;                 K.sup.+        
3-CH.sub.34-OC.sub.2 H.sub.5                                              
                &#34;         CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2   
                          H.sub.5        &#34;                 &#34;              
3-Cl4-CN        3-CH.sub.3                                                
                          CH.sub.2 CH.sub.3                               
                                         &#34;                 &#34;              
3-CH.sub.34-SCN &#34;         &#34;              &#34;                 &#34;              
3-Br4-COOCH.sub.3                                                         
                &#34;         &#34;              &#34;                 &#34;              
3-CH.sub.34-COOC.sub.2 H.sub.5                                            
                &#34;         &#34;              &#34;                 &#34;              
3-CH.sub.34-CONH.sub.2                                                    
                3-NHCOC.sub.6 H.sub.5                                     
                          &#34;              &#34;                 &#34;              
3-CH.sub.34-CONHC.sub.2 H.sub.4 OH                                        
                3-NHCONHC.sub.2 H.sub.5                                   
                          &#34;              &#34;                 &#34;              
3-CH.sub.34-CONHC.sub.4 H.sub.9 -n                                        
                3-NHCOCH.sub.2 OCH.sub.3                                  
                          &#34;              &#34;                 &#34;              
3-CH.sub.34-OC.sub.6 H.sub.5                                              
                3-NHCOC.sub.6 H.sub.11                                    
                          &#34;              &#34;                 &#34;              
3-CH.sub.34-OC.sub.6 H.sub.4 p-CH.sub.3                                   
                3-NHCOOC.sub.2 H.sub.5                                    
                          &#34;              CH.sub.2 CH(CH.sub.3)            
                                                           &#34;              
3-CH.sub.34-SC.sub.6 H.sub.5                                              
                3-NHCOCH.sub.2 CN                                         
                          &#34;              CH.sub.2 CH(CH.sub.2 OCH.sub.3)  
                                                           &#34;              
3-CH.sub.34-SCH.sub.2 CH.sub.2 OH                                         
                &#34;         &#34;              CH.sub.2 CH.sub.2 &#34;              
3-CH.sub.34-SCH.sub.2 CH.sub.3                                            
                None      &#34;              &#34;                 &#34;              
 ##STR48##      &#34;         &#34;              &#34;                                
3-CH.sub.34-Br  3-CH.sub.3                                                
                          &#34;              CH.sub.2 CH.sub.2 SCH.sub.2      
                                         CH.sub.2          &#34;              
&#34;               &#34;         &#34;              CH.sub.2 CH.sub.2 SO.sub.2       
                                         CH.sub.2 CH.sub.2 CH.sub.2       
                                         CH.sub.2          &#34;              
&#34;               &#34;         &#34;              CH.sub.2 CH.sub.2 N(SO.sub.2     
                                         CH.sub.3)CH.sub.2 CH.sub.2       
                                                           &#34;              
&#34;               &#34;         &#34;              CH.sub.2 CH.sub.2 N(COCH.sub.3)CH
                                         .sub.2 CH.sub.2   &#34;              
&#34;               &#34;         &#34;              CH.sub.2 CH.sub.2 SO.sub.2       
                                         NHCH.sub.2 CH.sub.2              
                                                           &#34;              
3-CH.sub.34-CONH.sub.2                                                    
                &#34;         &#34;              CH.sub.2 CH.sub.2 &#34;              
3-CH.sub.34-CONHC.sub.3 H.sub.6 OCH.sub.3                                 
                &#34;         &#34;              &#34;                 &#34;              
3-CH.sub.34-Cl  &#34;         &#34;              CH.sub.2 CH.sub.2 CONHC.sub.2    
                                         H.sub.4           &#34;              
&#34;               &#34;         &#34;              CH.sub.2 CH.sub.2                
                                                           &#34;HCOCH.sub.2   
&#34;               &#34;         &#34;              CH.sub.2 CH.sub.2 NHSO.sub.2     
                                         CH.sub.2 CH.sub.2 &#34;              
&#34;               3-NHCOC.sub.6 H.sub.5                                     
                          &#34;              CH.sub.2 CH.sub.2 &#34;              
&#34;               3-NHCOOC.sub.2 H.sub.5                                    
                          &#34;              &#34;                 &#34;              
&#34;               3-CH.sub.3                                                
                          CH.sub.2 CH.sub.2 OSO.sub.3 Na                  
                                         &#34;                 Na.sup.+       
&#34;               &#34;         C.sub.2 H.sub.5                                 
                                         CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2
                                                           &#34;              
__________________________________________________________________________
 
    
     
                                           TABLE 14                                
__________________________________________________________________________
 ##STR49##                                                                
Substituents on                                                           
Ring E         (R.sub.1).sub.m                                            
                         R.sub.3                                          
                            R.sub.4                                       
                                     Z                 M                  
__________________________________________________________________________
3-CH.sub.34-Br None      CH.sub.3                                         
                            CH.sub.3                                      
                                   CH.sub.2 CH.sub.2   K.sup.+            
  &#34;              &#34;       H  CH.sub.3                                      
                                     &#34;                 &#34;                  
  &#34;            7-CH.sub.3                                                 
                         &#34;  &#34;        &#34;                 &#34;                  
  &#34;              &#34;       CH.sub.3                                         
                            &#34;        &#34;                 &#34;                  
  &#34;            7-CH.sub.3                                                 
                         H  CH(CH.sub.3).sub.2                            
                                      &#34;                &#34;                  
  &#34;            7-OCH.sub.3                                                
                         &#34;  CH.sub.3                                      
                                     &#34;                 &#34;                  
  &#34;            5-OCH.sub.3, 8-CH.sub.3                                    
                         &#34;  &#34;        &#34;                 &#34;                  
  &#34;            5,8-di-OCH.sub.3                                           
                         &#34;  &#34;        &#34;                 &#34;                  
  &#34;            5,8-di-CH.sub.3                                            
                         &#34;  &#34;        &#34;                 &#34;                  
  &#34;            7-Cl      &#34;  &#34;        &#34;                 &#34;                  
  &#34;            5,8-di-Cl &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-CN None      &#34;  &#34;        &#34;                 Na.sup.+           
  &#34;            5-OCH.sub.3, 8-CH.sub.3                                    
                         CH.sub.3                                         
                            &#34;        &#34;                 &#34;                  
  &#34;            7-NHCHO   &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-COOC.sub.2 H.sub.5                                            
               7-NHCOCH.sub.3                                             
                         &#34;  &#34;        &#34;                 &#34;                  
  &#34;            7-NHCOCH.sub.2 OCH.sub.3                                   
                         &#34;  &#34;        &#34;                 &#34;                  
  &#34;            7-NHCOOC.sub.2 H.sub.5                                     
                         &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.3     7-NHCOC.sub.6 H.sub.5                                      
                         &#34;  &#34;        &#34;                 &#34;                  
  &#34;            7-NHCONHC.sub.2 H.sub.5                                    
                         &#34;  &#34;        &#34;                 K.sup.+            
3-CH.sub.34-Cl 7-NHCOC.sub.6 H.sub.11                                     
                         &#34;  &#34;        &#34;                 &#34;                  
  &#34;            None      &#34;  &#34;        &#34;                 &#34;                  
  &#34;            7-CH.sub.3                                                 
                         H  &#34;        &#34;                 &#34;                  
  &#34;              &#34;       &#34;  H        &#34;                 &#34;                  
3-Cl4-CN         &#34;       &#34;  CH.sub.3                                      
                                     &#34;                 &#34;                  
3-Br4-COOCH.sub.3                                                         
                 &#34;       &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-COOCH.sub.3                                                   
                 &#34;       &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-CONH.sub.2                                                    
                 &#34;       &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-COOCHC.sub.2 H.sub.4 OH                                       
                 &#34;       &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-CONHC.sub.4 H.sub.9 -n                                        
               7-OCH.sub.3                                                
                         &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-CONHC.sub.3 H.sub.6 OCH.sub.3                                 
               7-CH.sub.3                                                 
                         &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-COOC.sub.2 H.sub.4 OCH.sub.3                                  
                 &#34;       &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-SCH.sub.2 CH.sub.2 OH                                         
                 &#34;       &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-SCH.sub.2 CH.sub.2 OCOCH.sub.3                                
                 &#34;       &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-SCH.sub.3                                                     
                 &#34;       &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-SO.sub.2 CH.sub.3                                             
                 &#34;       &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-SC.sub.6 H.sub.5                                              
               None      &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-SC.sub.6 H.sub.4p-C(CH.sub.3).sub.3                           
                 &#34;       &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.34-SC.sub.6 H.sub.4p-Cl                                          
                 &#34;       &#34;  &#34;        &#34;                 &#34;                  
 ##STR50##       &#34;       &#34;  &#34;        &#34;                 &#34;                  
 ##STR51##     7-CH.sub.3                                                 
                         &#34;  &#34;        &#34;                 &#34;                  
 ##STR52##       &#34;       &#34;  &#34;        &#34;                 &#34;                  
3-CH.sub.3SC.sub.6 H.sub.11                                               
                 &#34;       &#34;  &#34;      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2   
                                                       &#34;                  
3-CH.sub.34-SCN                                                           
                 &#34;       &#34;  &#34;      CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2   
                                                       &#34;                  
3-CH.sub.34-OC.sub.6 H.sub.5                                              
                 &#34;       &#34;  &#34;      CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2    
                                   CH.sub.2            &#34;                  
3-CH.sub.34-OC.sub.2 H.sub.5                                              
                  &#34;      &#34;  &#34;      CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)C
                                   H.sub.2 CH.sub.2    &#34;                  
3-CH.sub.34-SCH.sub.2 CHCH.sub.2                                          
                 &#34;       &#34;  &#34;      CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2  
                                   CH.sub.2            &#34;                  
3-CH.sub.34-Br   &#34;       &#34;  &#34;      CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.2
                                                       &#34;                  
  &#34;              &#34;       &#34;  &#34;      CH.sub.2 CH.sub.2 CONHCH.sub.2         
                                                       &#34;H.sub.2           
  &#34;              &#34;       &#34;  &#34;      CH.sub.2 CH.sub.2 N(COC.sub.6 H.sub.5)C
                                   H.sub.2 CH.sub.2    &#34;                  
  &#34;              &#34;       &#34;  &#34;      CH.sub.2 CH.sub.2 (CH.sub.3)           
                                                       &#34;                  
  &#34;              &#34;       &#34;  &#34;      CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2      
                                                       Na.sup.+           
  &#34;              &#34;       &#34;  &#34;      CH.sub.2 CH(CH.sub.2)Cl                
                                                       &#34;                  
  &#34;              &#34;       &#34;  &#34;      CH.sub.2 CH(C.sub.6 H.sub.5)           
                                                       &#34;                  
  &#34;              &#34;       &#34;  &#34;      CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5) 
                                                       &#34;                  
  &#34;              &#34;       &#34;  &#34;      CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3)S
                                   O.sub.2 CH.sub.2 CH.sub.2              
                                                       &#34;                  
  &#34;              &#34;       &#34;  &#34;      CH.sub.2 CH.sub.2 CH.sub.2             
                                                       &#34;                  
__________________________________________________________________________
 
    
     
                                           TABLE 15                                
__________________________________________________________________________
 ##STR53##                                                                
Substituents on                                                           
Ring E             (R.sub.1).sub.m                                        
                             R.sub.3                                      
                                   Z                M                     
__________________________________________________________________________
3-CH.sub.2Cl       None      H   CH.sub.2 CH.sub.2  Na.sup.+              
  &#34;                6-CH.sub.3                                             
                             &#34;     &#34;                &#34;                     
  &#34;                  &#34;       3-CH.sub.3                                   
                                   &#34;                &#34;                     
  &#34;                6-OCH.sub.3                                            
                             &#34;     &#34;                &#34;                     
3-Cl4-CN             &#34;       H     &#34;                &#34;                     
  &#34;                6-CH.sub.3                                             
                             3-CH.sub.3                                   
                                 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      
                                                    &#34;                     
3-CH.sub.3           &#34;       &#34;   CH.sub.2 CH.sub.2  &#34;                     
3-CH.sub.34-COOC.sub.2 H.sub.5                                            
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-CONH.sub.2                                                    
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-CONHC.sub.2 H.sub.4 OH                                        
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-CONHC.sub.4 H.sub.9 -n                                        
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-CONHC.sub.3 H.sub.6 OCH.sub.3                                 
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                          
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-CONHCH.sub.3                                                  
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-Br     6-NHCOCH.sub.3                                         
                             &#34;     &#34;                K.sup.+               
  &#34;                6-NHCOC.sub.6 H.sub.5                                  
                             &#34;     &#34;                &#34;                     
  &#34;                6-NHCOC.sub.4 H.sub.9 -n                               
                             &#34;     &#34;                &#34;                     
  &#34;                6-NHCONHC.sub.2 H.sub.5                                
                             &#34;     &#34;                &#34;                     
  &#34;                6-NHCOCH.sub.2 OCH.sub.3                               
                             &#34;     &#34;                &#34;                     
  &#34;                6-NHCOCH.sub.2 CN                                      
                             &#34;     &#34;                &#34;                     
3-CH.sub.34-SC.sub.2 H.sub.5                                              
                   6-CH.sub.3                                             
                             &#34;     &#34;                Na.sup.+              
3-CH.sub.34-SCH.sub.2 CH.sub.2 OH                                         
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-SCH.sub.3 CHCH.sub.2                                          
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-SCH.sub.2 CH.sub.2 OCOCH.sub.3                                
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-SC.sub.6 H.sub.5                                              
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-SC.sub.6 H.sub.4 -p-C(CH.sub.3).sub.2                         
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-SC.sub.6 H.sub.11                                             
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-SO.sub.2 CH.sub.2 CH.sub.2 OH                                 
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-SO.sub. 2 CH.sub.2 CH.sub.3                                   
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-OC.sub.6 H.sub.5                                              
                   6-NHCHO   &#34;     &#34;                &#34;                     
3-CH.sub.34-OC.sub.6 H.sub.4 -p-OCH.sub.3                                 
                   6-CH.sub.3                                             
                             &#34;     &#34;                &#34;                     
 ##STR54##           &#34;       &#34;     &#34;                &#34;                     
 ##STR55##           &#34;       &#34;     &#34;                &#34;                     
 ##STR56##           &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.3-SCH.sub.2 CH(OH)CH.sub.2 OH                                    
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-SCH.sub.2 COOCH.sub.3                                         
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-OC.sub.2 H.sub.5                                              
                     &#34;       &#34;     &#34;                &#34;                     
3-CH.sub.34-Br       &#34;       &#34;     &#34;                &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH(CH.sub.3)                    
                                                    &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH(C.sub.6 H.sub.5)             
                                                    &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH(CH.sub.2 Cl)                 
                                                    &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH(OSO.sub.3 K)CH.sub.2         
                                                    &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)   
                                                    &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     
                                                    &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2     
                                                    &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 SO.sub.2 CH.sub. 2     
                                 CH.sub.2           &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.
                                 sub.2 CH.sub.2     &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 N(SO.sub.2 C.sub.6     
                                 H.sub.5)CH.sub.2 CH.sub.2                
                                                    &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 SO.sub.2 N(CH.sub.3)CH.
                                 sub.2 CH.sub.2     &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 NHCOCH.sub.2           
                                                    &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 CH.sub.2 NHSO.sub.2    
                                 CH.sub.2 CH.sub.2  &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2  
                                                    &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2  
                                 CH.sub.2 CH.sub.2  &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 SO.sub.2 N(C.sub.6     
                                 H.sub. 5)CH.sub.2 CH.sub.2               
                                                    &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 NHCONHCH.sub.2         
                                                    &#34;H.sub.2              
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 CH.sub.2               
                                                    &#34;                     
  &#34;                  &#34;       &#34;   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2SCH.su
                                 b.2 CH.sub.2       &#34;                     
__________________________________________________________________________
 
    
     
                                           TABLE 16                                
__________________________________________________________________________
 ##STR57##                                                                
       Substituents on                                                    
A      Ring F     (R.sub.1).sub.m                                         
                             R.sub.2       Z               M              
__________________________________________________________________________
H      4-CN       None       C.sub.2 H.sub.5                              
                                           CH.sub.2 CH.sub.2              
                                                           K.sup.+        
  &#34;      &#34;          &#34;        C.sub.6 H.sub.11                             
                                             &#34;             &#34;              
  &#34;      &#34;          &#34;        C.sub.6 H.sub.5                              
                                             &#34;             &#34;              
  &#34;      &#34;        3-CH.sub.3 C.sub.2 H.sub.5                              
                                             &#34;             &#34;              
  &#34;      &#34;          &#34;        CH.sub.2 C.sub.6 H.sub.5                     
                                             &#34;             &#34;              
  &#34;      &#34;          &#34;        CH.sub.2 CH.sub.2 OCH.sub.3                  
                                           CH.sub.2 CH.sub.2 CH.sub.2     
                                           CH.sub.2        &#34;              
  &#34;      &#34;          &#34;        CH.sub.2 CH.sub.2 CONH.sub.2                 
                                           CH.sub.2 CH.sub.2              
                                                           &#34;              
  &#34;      &#34;          &#34;        CH.sub.2 CH.sub.2 Cl                         
                                             &#34;             &#34;              
  &#34;      &#34;        3-NHCOCH.sub.3                                          
                             C.sub.2 H.sub.5                              
                                             &#34;             &#34;              
  &#34;      &#34;        2-CH.sub.35-NHCOCH.sub.3                                
                             H               &#34;             &#34;              
  &#34;      &#34;        2-OCH.sub.35-CH.sub.3                                   
                             &#34;               &#34;             &#34;              
  &#34;      &#34;        2-Cl       &#34;               &#34;             &#34;              
  &#34;      &#34;        2-CH.sub.3 &#34;               &#34;             &#34;              
  &#34;      &#34;        2,5-di-Cl  &#34;               &#34;             &#34;              
  &#34;      &#34;        2-OCH.sub. 35-Cl                                        
                             &#34;               &#34;             &#34;              
  &#34;      &#34;        2-OCH.sub.35-CH.sub.3                                   
                             &#34;               &#34;             &#34;              
C.sub.6 H.sub.5                                                           
       3-SC.sub.2 H.sub.54-CN                                             
                  2,5-di-CH.sub.3                                         
                             &#34;               &#34;             Na.sup.+       
  &#34;    3-SC.sub.2 H.sub.54-COOCH.sub.3                                    
                  3-CH.sub.3                                              
                              ##STR58##      &#34;             &#34;              
  &#34;    3-SC.sub.2 H.sub.54-CONH.sub.2                                     
                  3-CH.sub.3                                              
                              ##STR59##    CH.sub.2 CH(CH.sub.2 Cl)       
                                                           &#34;              
  &#34;    3-SCH.sub.34-CN                                                    
                  3-CH.sub.3                                              
                              ##STR60##    CH.sub.2 CH.sub.2              
                                                           NH.sub.4.sup.+ 
  &#34;      &#34;        3-CH.sub.3                                              
                              ##STR61##      &#34;             K.sup.+        
  &#34;      &#34;        3-CH.sub.3 CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3        
                                             &#34;             &#34;              
  &#34;      &#34;        3-CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3      
                                             &#34;             &#34;              
SO.sub.2 C.sub.6 H.sub.5                                                  
         &#34;        None       CH.sub.3      CH.sub.2 CH.sub.2              
                                                           &#34;              
COCH.sub.3                                                                
       4-CN       3-CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2                  
                                           CH.sub.2 CH.sub.2 OCH.sub.2    
                                           CH.sub.2        &#34;              
H        &#34;          &#34;        CH.sub.2 C.sub.6 H.sub.11                    
                                           CH.sub.2 CH.sub.2              
                                                           &#34;              
  &#34;      &#34;          &#34;        CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5           
                                             &#34;             &#34;              
  &#34;      &#34;          &#34;        CH(CH.sub.3).sub.2                           
                                             &#34;             &#34;              
COOC.sub.2 H.sub.5                                                        
         &#34;        H          CH.sub.2 CH.sub.3                            
                                             &#34;             K.sup.+        
H        &#34;          &#34;        CH.sub.2 CH.sub. 2 OCH.sub.2 CH.sub.2        
                             OC.sub.2 H.sub.5                             
                                             &#34;             &#34;              
CH.sub.3                                                                  
       4-CN       3-CH.sub.3 CH.sub.2 CH.sub.3                            
                                             &#34;             &#34;              
  &#34;    4-COOCH.sub.3                                                      
                    &#34;          &#34;             &#34;             &#34;              
  &#34;    4-CONH.sub.2                                                       
                    &#34;          &#34;             &#34;             &#34;              
CH.sub.2 CH.sub.3                                                         
       4-CN         &#34;          &#34;             &#34;             &#34;              
C.sub.2 H.sub.5                                                           
         &#34;        3-NHCOC.sub.6 H.sub.5                                   
                               &#34;             &#34;             &#34;              
  &#34;    4-COOCH.sub.3                                                      
                  3-NHCONHC.sub.2 H.sub.5                                 
                               &#34;             &#34;             &#34;              
C.sub.6 H.sub.4 -p-Cl                                                     
         &#34;        3-NHCOCH.sub.2 OCH.sub.3                                
                               &#34;             &#34;             &#34;              
C.sub.6 H.sub.4 -o-CH.sub.3                                               
         &#34;        3-NHCOC.sub.6 H.sub.11                                  
                               &#34;             &#34;             &#34;              
C.sub.6 H.sub.5                                                           
         &#34;        3-NHCOOC.sub.2 H.sub.5                                  
                               &#34;           CH.sub.2 CH(CH.sub.3)          
                                                           &#34;              
   &#34;     &#34;        3-NHCOCH.sub.2 N                                        
                               &#34;           CH.sub.2 CH(CH.sub.2 OCH.sub.3)
                                                           &#34;              
H      4-CONHC.sub.2 H.sub.4 OH                                           
                    &#34;          &#34;           CH.sub.2 CH.sub.2              
                                                           &#34;              
  &#34;    4-CONHC.sub.4 H.sub.9 -n                                           
                  None         &#34;             &#34;             &#34;              
  &#34;    4-COOC.sub.2 H.sub.4 OCH.sub.3                                     
                    &#34;          &#34;             &#34;             &#34;              
  &#34;    4-CONHC.sub.3 H.sub.6 OCH.sub.3                                    
                  3-CH.sub.3   &#34;           CH.sub.2 CH.sub.2 SCH.sub.2    
                                           CH.sub.2        &#34;              
  &#34;    4-CN         &#34;          &#34;           CH.sub.2 CH.sub.2 SO.sub.2     
                                           CH.sub.2                       
                                           CH.sub.2 CH.sub.2 CH.sub.2     
                                                           &#34;              
  &#34;      &#34;          &#34;          &#34;           CH.sub.2 CH.sub.2 N(SO.sub.2   
                                           CH.sub.3)CH.sub.2 CH.sub.2     
                                                           &#34;              
  &#34;      &#34;          &#34;          &#34;           CH.sub.2 CH.sub.2 N(COCH.sub.3)
                                           CH.sub.2 CH.sub.2              
                                                           &#34;              
  &#34;      &#34;          &#34;          &#34;           CH.sub.2 CH.sub.2 SO.sub.2     
                                           NHCH.sub.2 CH.sub.2            
                                                           &#34;              
SO.sub.2 CH.sub.3                                                         
       4-CN         &#34;          &#34;           CH.sub.2 CH.sub.2              
                                                           &#34;              
SO.sub.2 C.sub.6 H.sub.5                                                  
         &#34;          &#34;          &#34;             &#34;             &#34;              
SO.sub.2 CH.sub.2 CH.sub.3                                                
         &#34;          &#34;          &#34;           CH.sub.2 CH.sub.2 CONHC.sub.2  
                                           H.sub.4         &#34;              
H        &#34;          &#34;          &#34;           CH.sub.2 CH.sub.2 NHCOCH.sub.2 
                                                           &#34;              
  &#34;      &#34;          &#34;          &#34;           CH.sub.2 CH.sub.2 NHSO.sub.2   
                                           CH.sub.2 CH.sub.2              
                                                           &#34;              
  &#34;      &#34;        3-NHCOC.sub.6 H.sub.5                                   
                               &#34;           CH.sub.2 CH.sub.2              
                                                           &#34;              
  &#34;      &#34;        3-NHCOOC.sub.2 H.sub. 5                                 
                               &#34;             &#34;             &#34;              
  &#34;      &#34;        3-CH.sub.3 CH.sub.2 CH.sub.2 OSO.sub.3 Na               
                                             &#34;             Na.sup.+       
  &#34;      &#34;          &#34;        C.sub.2 H.sub.5                              
                                           CH.sub.2 CH(OSO.sub.3 Na)CH.sub
                                           .2              &#34;              
__________________________________________________________________________
 
    
     
                                           TABLE 17                                
__________________________________________________________________________
 ##STR62##                                                                
        Substituents on                                                   
A       Ring F      (R.sub.1).sub.m                                       
                               R.sub.3                                    
                                  R.sub.4                                 
                                          Z                M              
__________________________________________________________________________
H       4-CN        None       CH.sub.3                                   
                                  CH.sub.3                                
                                         CH.sub.2 CH.sub.2 K.sup.+        
&#34;         &#34;           &#34;        H  CH.sub.3                                
                                          &#34;                &#34;              
&#34;         &#34;         7-CH.sub.3 &#34;  &#34;       &#34;                &#34;              
&#34;         &#34;           &#34;        CH.sub.3                                   
                                  &#34;       &#34;                &#34;              
&#34;         &#34;         7-CH.sub.3 H  CH(CH.sub.3).sub.2                      
                                          &#34;                &#34;              
&#34;         &#34;         7-OCH.sub.3                                           
                               &#34;  CH.sub.3                                
                                          &#34;                &#34;              
&#34;         &#34;         5-OCH.sub.3, 8-CH.sub.3                               
                               &#34;  &#34;       &#34;                &#34;              
&#34;         &#34;         5,8-di-OCH.sub.3                                      
                               &#34;  &#34;       &#34;                &#34;              
&#34;         &#34;         5,8-di-CH.sub.3                                       
                               &#34;  &#34;       &#34;                &#34;              
&#34;         &#34;         7-Cl       &#34;  &#34;       &#34;                &#34;              
&#34;         &#34;         5,8-di-Cl  &#34;  &#34;       &#34;                &#34;              
CH.sub.3                                                                  
          &#34;         None       &#34;  &#34;       &#34;                Na.sup.+       
&#34;         &#34;         5-OCH.sub.3, 8-CH.sub.3                               
                               CH.sub.3                                   
                                  &#34;       &#34;                &#34;              
H       4-COOCH.sub.3                                                     
                    7-NHCHO    &#34;  &#34;       &#34;                &#34;              
H       4-COOC.sub.2 H.sub.5                                              
                    7-NHCOCH.sub.3                                        
                               &#34;  &#34;       &#34;                &#34;              
H       4-COOC.sub. 2 H.sub.4 OCH.sub.3                                   
                    7-NHCOCH.sub.2 OCH.sub.3                              
                               &#34;  &#34;       &#34;                &#34;              
H       4-CONH.sub.2                                                      
                    7-NHCOOC.sub.2 H.sub.5                                
                               &#34;  &#34;       &#34;                &#34;              
H       4-CONHC.sub.2 H.sub.5                                             
                    7-NHCOC.sub.6 H.sub.5                                 
                               &#34;  &#34;       &#34;                &#34;              
&#34;         &#34;         7-NHCONHC.sub.2 H.sub.5                               
                               &#34;  &#34;       &#34;                K.sup.+        
&#34;         &#34;         7-NHCOC.sub.6 H.sub.11                                
                               &#34;  &#34;       &#34;                &#34;              
C.sub.6 H.sub.5                                                           
        4-CN        None       &#34;  &#34;       &#34;                &#34;              
&#34;         &#34;         7-CH.sub.3 H  &#34;       &#34;                &#34;              
C.sub.6 H.sub.4 -p-Cl                                                     
          &#34;           &#34;        &#34;  H       &#34;                &#34;              
C.sub.6 H.sub.4 -p-CH.sub.3                                               
          &#34;           &#34;        &#34;  CH.sub.3                                
                                          &#34;                &#34;              
SO.sub.2 CH.sub.3                                                         
          &#34;           &#34;        &#34;  &#34;       &#34;                &#34;              
&#34;       4-COOCH.sub. 3                                                    
                      &#34;        &#34;  &#34;       &#34;                &#34;              
SO.sub.2 C.sub.6 H.sub.5                                                  
          &#34;           &#34;        &#34;  &#34;       &#34;                &#34;              
&#34;       4-CN          &#34;        &#34;  &#34;       &#34;                &#34;              
&#34;       4-CONH.sub.2 H.sub.4 OH                                           
                    7-OCH.sub.3                                           
                               &#34;  &#34;       &#34;                &#34;              
&#34;       4-COOCH(CH.sub.3).sub.2                                           
                    7-CH.sub.3 &#34;  &#34;       &#34;                &#34;              
CH.sub.3                                                                  
        3-SC.sub.2 H.sub.5 -4-CN                                          
                      &#34;        &#34;  &#34;       &#34;                &#34;              
C.sub.6 H.sub.5                                                           
          &#34;           &#34;        &#34;  &#34;       &#34;                &#34;              
&#34;       3-SC.sub.2 H.sub.5 -4-COOCH.sub.3                                 
                      &#34;        &#34;  &#34;       &#34;                &#34;              
&#34;       3-SCH.sub.3 -4-COOC.sub.2 H.sub.5                                 
                      &#34;        &#34;  &#34;       &#34;                &#34;              
&#34;       3-SO.sub.2 CH.sub.3 -4-COOCH.sub.3                                
                      &#34;        &#34;  &#34;       &#34;                &#34;              
&#34;       3-SC.sub.6 H.sub.5 -4-COOCH.sub.3                                 
                    None       &#34;  &#34;       &#34;                &#34;              
COCH.sub.3                                                                
        4-CN          &#34;        &#34;  &#34;       &#34;                &#34;              
&#34;       4-COOCH.sub.3                                                     
                      &#34;        &#34;  &#34;       &#34;                &#34;              
CH.sub.2 CH.sub.2 OH                                                      
          &#34;           &#34;        &#34;  &#34;       &#34;                &#34;              
H       3-CH.sub.2 CN-4-CN                                                
                    7-CH.sub.3 &#34;  &#34;       &#34;                &#34;              
H       3-CH.sub.2 CONH.sub.2 -4-CN                                       
                      &#34;        &#34;  &#34;       &#34;                &#34;              
H       4-CN          &#34;        &#34;  &#34;     CH.sub.2 CH.sub.2 OCH.sub.2       
                                        CH.sub.2           &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH.sub.2 SCH.sub.2       
                                        CH.sub.2           &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH.sub.2 SO.sub.2        
                                        CH.sub.2 CH.sub.2  &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH.sub.2 N(SO.sub.2      
                                        CH.sub.3)CH.sub.2 CH.sub.2        
                                                           &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH.sub.2 SO.sub.2        
                                        NHCH.sub.2 CH.sub.2               
                                                           &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2        
                                        NHCOCH.sub.2       &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH.sub.2 CONHCH.sub.2    
                                        CH.sub.2           &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH.sub.2 N(COC.sub.6     
                                        H.sub.5)CH.sub.2 CH.sub.2         
                                                           &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH.sub.2 (CH.sub.3).sub.2
                                                           &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2 
                                                           Na.sup.+       
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH(CH.sub.2 Cl)          
                                                           &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH(CH.sub.2 OCH.sub.3)   
                                                           &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH(C.sub.6 H.sub.5)      
                                                           &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH(CH.sub.2 OC.sub.6     
                                        H.sub.5)           &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2        
                                        N(CH.sub.3)SO.sub.2 CH.sub.2      
                                        CH.sub.2           &#34;              
&#34;         &#34;           &#34;        &#34;  &#34;     CH.sub.2 CH.sub.2 CH.sub.2        
                                                           &#34;              
__________________________________________________________________________
 
    
     
                                           TABLE 18                                
__________________________________________________________________________
 ##STR63##                                                                
          Substituents                                                    
A         on Ring F      (R.sub.1).sub.m                                  
                                    R.sub.3                               
                                         Z                  M             
__________________________________________________________________________
H         4-CN           None       H    CH.sub.2 CH.sub.2  Na.sup.+      
&#34;         &#34;              6-CH.sub.3 &#34;    &#34;                  &#34;             
CH.sub.3  &#34;              &#34;          3-CH.sub.3                            
                                         &#34;                  &#34;             
&#34;         4-COOCH.sub.3  6-OCH.sub.3                                      
                                    &#34;    &#34;                  &#34;             
&#34;         4-COOC.sub.2 H.sub.4 OC.sub.2 H.sub.5                           
                         &#34;          H    &#34;                  &#34;             
&#34;         4-CONH.sub.2   6-CH.sub.3 3-CH.sub.3                            
                                         CH.sub.2 CH.sub.2 CH.sub.2       
                                         CH.sub.2           &#34;             
&#34;         4-CONHC.sub.2 H.sub.4 OH                                        
                         &#34;          &#34;    CH.sub.2 CH.sub.2  &#34;             
&#34;         4-CONHC.sub.3 H.sub.6 OCH.sub.3                                 
                         &#34;          &#34;    &#34;                  &#34;             
&#34;         4-CONHC.sub.2 H.sub.4 NHCOCH.sub.3                              
                         &#34;          &#34;    &#34;                  &#34;             
CH.sub.2 CH.sub.3                                                         
          4-CN           &#34;          &#34;    &#34;                  &#34;             
C.sub.6 H.sub.5                                                           
          &#34;              &#34;          &#34;    &#34;                  &#34;             
&#34;         4-COOCH.sub.2 CH.sub.3                                          
                         &#34;          &#34;    &#34;                  &#34;             
&#34;         4-CONH.sub.2   &#34;          &#34;    &#34;                  &#34;             
C.sub.6 H.sub.4 -o-Cl                                                     
          &#34;              &#34;          &#34;    &#34;                  &#34;             
H         &#34;              6-NHCOCH.sub. 3                                  
                                    &#34;    &#34;                  K.sup.+       
&#34;         4-COOCH.sub.3  6-NHCOC.sub.6 H.sub.5                            
                                    &#34;    &#34;                  &#34;             
&#34;         &#34;              6-NHCOC.sub.4 H.sub.9 -n                         
                                    &#34;    &#34;                  &#34;             
&#34;         4-CONHC.sub.4 H.sub. 9 -n                                       
                         6-NHCONHC.sub.2 H.sub.5                          
                                    &#34;    &#34;                  &#34;             
&#34;         &#34;              6-NHCOCH.sub.2 OCH.sub.3                         
                                    &#34;    &#34;                  &#34;             
&#34;         &#34;              6-NHCOCH.sub.2 CN                                
                                    &#34;    &#34;                  &#34;             
SO.sub.2 CH.sub.3                                                         
          HCN            6-CH.sub.3 &#34;    &#34;                  Na.sup.+      
&#34;         4-COOCH.sub.3  &#34;          &#34;    &#34;                  &#34;             
H         3-CH.sub. 2 CN-4-CN                                             
                         &#34;          &#34;    &#34;                  &#34;             
C.sub.6 H.sub.5                                                           
          3-SCH.sub.3 -4-CN                                               
                         &#34;          &#34;    &#34;                  &#34;             
&#34;         3-SCH.sub.2 CH.sub.3 -4-CN                                      
                         &#34;          &#34;    &#34;                  &#34;             
&#34;         3-SCH.sub.2 CH.sub.3 -4-COOCH.sub. 3                            
                         &#34;          &#34;    &#34;                  &#34;             
&#34;         3-SCH.sub.3 -4-CONHC.sub. 4 H.sub.9 -n                          
                         &#34;          &#34;    &#34;                  &#34;             
SO.sub.2 C.sub.6 H.sub.5                                                  
          4-CN           &#34;          &#34;    &#34;                  &#34;             
&#34;         4-COOCH.sub.3  &#34;          &#34;    &#34;                  &#34;             
SO.sub.2 C.sub.6 H.sub.4 -p-CH.sub. 3                                     
          4-CN           6-NHCHO    &#34;    &#34;                  &#34;             
SO.sub.2 C.sub.4 H.sub.9 -n                                               
          &#34;              6-CH.sub.3 &#34;    &#34;                  &#34;             
COCH.sub.3                                                                
          &#34;              &#34;          &#34;    &#34;                  &#34;             
COOC.sub.2 H.sub.5                                                        
          &#34;              &#34;          &#34;    &#34;                  &#34;             
CH.sub.2 CH.sub.2 OH                                                      
          &#34;              &#34;          &#34;    &#34;                  &#34;             
C.sub.6 H.sub.4OCH.sub.3                                                  
          &#34;              &#34;          &#34;    &#34;                  &#34;             
&#34;         4-COOCH.sub.3  &#34;          &#34;    &#34;                  &#34;             
&#34;         4-COOCH(CH.sub.3).sub.2                                         
                         &#34;          &#34;    &#34;                  &#34;             
SO.sub.2 C.sub.6 H.sub.11                                                 
          &#34;              &#34;          &#34;    &#34;                  &#34;             
H         4-CN           &#34;          &#34;    CH.sub.2 CH(CH.sub.3)            
                                                            &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH(C.sub.6 H.sub.5)     
                                                            &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH(CH.sub.2 Cl)         
                                                            &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH(OSO.sub.3 K)CH.sub.2 
                                                            &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH(CH.sub.2 OC.sub.6    
                                         H.sub.5)           &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 OCH.sub.2      
                                         CH.sub.2           &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 SCH.sub.2      
                                         CH.sub.2           &#34;             
C.sub.6 H.sub.5                                                           
          &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 SO.sub.2       
                                         CH.sub.2 CH.sub.2  &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 N(SO.sub.2     
                                         CH.sub.3)CH.sub.2 CH.sub.2       
                                                            &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 N(SO.sub.2     
                                         C.sub.6 H.sub.5)CH.sub.2         
                                                            &#34;H.sub.2      
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 SO.sub.2       
                                         N(CH.sub.3)CH.sub.2 CH.sub.2     
                                                            &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 NHCOCH.sub.2   
                                                            &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 CH.sub.2       
                                         NHSO.sub.2 CH.sub.2 CH.sub.2     
                                                            &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 CONHCH.sub.2   
                                         CH.sub.2           &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 CONHCH.sub.2   
                                         CH.sub.2 CH.sub.2                
                                                            &#34;H.sub.2      
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 SO.sub.2       
                                         N(C.sub.6 H.sub.5)CH.sub.2       
                                         CH.sub.2           &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 NHCONHCH.sub.2 
                                         CH.sub.2           &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 CH.sub.2       
                                                            &#34;             
&#34;         &#34;              &#34;          &#34;    CH.sub.2 CH.sub.2 CH.sub.2       
                                         CH.sub.2SCH.sub.2 CH.sub.2       
                                                            &#34;             
__________________________________________________________________________
 
    
     
                                           TABLE 19                                
__________________________________________________________________________
 ##STR64##                                                                
Substituents on                                                           
Ring G               (R.sub.1).sub.m                                      
                               R.sub.2      Z               M             
__________________________________________________________________________
3,5-di-CN-4-CH.sub.3                                                      
                   None      C.sub.2 H.sub.5                              
                                          CH.sub.2 CH.sub.2               
                                                           K.sup.+        
&#34;                  &#34;         C.sub.6 H.sub.11                             
                                          &#34;                &#34;              
&#34;                  &#34;         C.sub.6 H.sub.5                              
                                          &#34;                &#34;              
&#34;                  3CH.sub.3 C.sub.2 H.sub.5                              
                                          &#34;                &#34;              
3-CN-5-C.sub.6 H.sub.5                                                    
                   &#34;         CH.sub.2 C.sub.6 H.sub.5                     
                                          &#34;                &#34;              
3-COOCH.sub.3 -5-C.sub.6 H.sub.5                                          
                   &#34;         CH.sub.2 CH.sub.2 OCH.sub.3                  
                                          CH.sub.2 CH.sub.2 CH.sub.2      
                                          CH.sub.2         &#34;              
3-CONH.sub.2 -5-C.sub.6 H.sub.5                                           
                   &#34;         CH.sub.2 CH.sub.2 CONH.sub.2                 
                                          CH.sub.2 CH.sub.2               
                                                           &#34;              
3-CONHC.sub.2 H.sub.5 -5-C.sub.6 H.sub.5                                  
                   &#34;         CH.sub.2 CH.sub.2 Cl                         
                                          &#34;                &#34;              
3-COOCH.sub.3      3-NHCOCH.sub.3                                         
                             C.sub.2 H.sub.5                              
                                          &#34;                &#34;              
3-CN               2-CH.sub.3 -5-NHCOCH.sub.3                             
                             H            &#34;                &#34;              
3-CN-4-CH.sub.3 -5-COOC.sub.2 H.sub.5                                     
                   2-OCH.sub.3 -5-CH.sub.3                                
                             &#34;            &#34;                &#34;              
&#34;                  2-Cl      &#34;            &#34;                &#34;              
&#34;                  2-CH.sub.3                                             
                             &#34;            &#34;                &#34;              
&#34;                  2,5-di-Cl &#34;            &#34;                &#34;              
3-CN-4-CH.sub.3 -5-COCH.sub.3                                             
                   2-OCH.sub.3 -5-Cl                                      
                             &#34;            &#34;                &#34;              
3-COOCH.sub.3 -4-CH.sub.3 -5-CN                                           
                   2-OCH.sub.3 -5-CH.sub.3                                
                             &#34;            &#34;                &#34;              
3-COOCH.sub.3 -4-CH.sub.3 -5-COC.sub.6 H.sub.5                            
                   2,5-di-CH.sub.3                                        
                             &#34;            &#34;                Na.sup.+       
3-COOCH.sub.3 -5-COC.sub.6 H.sub.5                                        
                   3-CH.sub.3                                             
                              ##STR65##   &#34;                &#34;              
3-COOCH.sub.3 -5-COCH(CH.sub.3).sub.2                                     
                   3-CH.sub.3                                             
                              ##STR66##   CH.sub.2 CH(CH.sub.2 Cl)        
                                                           &#34;              
&#34;                  3-CH.sub.3                                             
                              ##STR67##   CH.sub.2 CH.sub.2               
                                                           NH.sub.4.sup.+ 
&#34;                  3-CH.sub.3                                             
                              ##STR68##   &#34;                K.sup.+        
&#34;                  3-CH.sub.3                                             
                             CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3        
                                          &#34;                &#34;              
&#34;                  3-CH.sub.3                                             
                             CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3      
                                          &#34;                &#34;              
&#34;                  None      CH.sub.3     CH.sub.2 CH.sub.2               
                                                           &#34;              
3-SO.sub.2 C.sub.6 H.sub.5 -5-COCH.sub.3                                  
                   3-CH.sub.3                                             
                             CH.sub.2 CH(CH.sub.3).sub.2                  
                                          CH.sub.2 CH.sub.2 OCH.sub.2     
                                          CH.sub.2         &#34;              
3-SO.sub.2 CH.sub.3 -5-CN                                                 
                   &#34;         CH.sub.2 C.sub.6 H.sub.11                    
                                          CH.sub.2 CH.sub.2               
                                                           &#34;              
3-SO.sub.2 C.sub.6 H.sub.5 -5-Br                                          
                   &#34;         CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5           
                                          &#34;                &#34;              
3,5-di-SO.sub.2 CH.sub.3                                                  
                   &#34;         CH(CH.sub.3).sub.2                           
                                          &#34;                &#34;              
3,5-di-SO.sub.2 NH.sub.2                                                  
                   H         CH.sub.2 CH.sub.3                            
                                          &#34;                K.sup.+        
3,5-di-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                  
                   &#34;         CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2         
                             OC.sub.2 H.sub.5                             
                                          &#34;                &#34;              
3-CN-5-COCH.sub.3  3-CH.sub.3                                             
                             CH.sub.2 CH.sub.3                            
                                          &#34;                &#34;              
3-CN-5-COOC(CH.sub.3).sub.2                                               
                   &#34;         &#34;            &#34;                &#34;              
3-CN-5-COOC.sub.2 H.sub.5                                                 
                   &#34;         &#34;            &#34;                &#34;              
3-CONH.sub.2 -5-COOC.sub.2 H.sub.5                                        
                   &#34;         &#34;            &#34;                &#34;              
3-CONH.sub.2 -5-COCH(CH.sub.3).sub.2                                      
                   3-NHCOC.sub.6 H.sub.5                                  
                             &#34;            &#34;                &#34;              
3-CONHC.sub.2 H.sub.4 OH-5-COCH(CH.sub.3).sub.2                           
                   3-NHCONHC.sub.2 H.sub.5                                
                             &#34;            &#34;                &#34;              
&#34;                  3-NHCOCH.sub.2 OCH.sub.3                               
                             &#34;            &#34;                &#34;              
&#34;                  3-NHCOC.sub.6 H.sub.11                                 
                             &#34;            &#34;                &#34;              
&#34;                  3-NHCOOC.sub.2 H.sub.5                                 
                             &#34;            CH.sub.2 CH(CH.sub.3)           
                                                           &#34;              
&#34;                  3-NHCOCH.sub.2 CN                                      
                             &#34;            CH.sub.2 CH(CH.sub.2 OCH.sub.3) 
                                                           &#34;              
3-CONHC.sub.3 H.sub.6 OCH.sub.3 -5-COCH(CH.sub.3).sub.2                   
                   &#34;         &#34;            CH.sub. 2 CH.sub.2              
                                                           &#34;              
3-CONHC.sub.4 H.sub.9 -n-5-COCH(CH.sub.3).sub.2                           
                   None      &#34;            &#34;                &#34;              
3-CONHC.sub.2 H.sub.4 OH-5-COCH(CH.sub.3).sub.2                           
                   &#34;         &#34;            &#34;                &#34;              
3-COOCH.sub.3 -5-SO.sub.2 CH.sub.3                                        
                   3-CH.sub.3                                             
                             &#34;            CH.sub.2 CH.sub.2 SCH.sub.2     
                                          CH.sub.2         &#34;              
3-CONHC.sub.2 H.sub.5 -5-SO.sub.2 CH.sub.3                                
                   &#34;         &#34;            CH.sub.2 CH.sub.2 SO.sub.2      
                                          CH.sub.2 CH.sub.2 CH.sub.2      
                                          CH.sub.2         &#34;              
3-CONH.sub.2 -5-SO.sub.2 CH.sub.3                                         
                   &#34;         &#34;            CH.sub.2 CH.sub.2 N(SO.sub.2    
                                          CH.sub.3)CH.sub.2 CH.sub.2      
                                                           &#34;              
3-CONH.sub.2 -5-SO.sub.2 C.sub.4 H.sub.9 -n                               
                   &#34;         &#34;            CH.sub.2 CH.sub.2 N(COCH.sub.3)C
                                          H.sub.2 CH.sub.2 &#34;              
3-COOCH.sub.3 -HCH.sub.3 -5-SCN                                           
                   &#34;         &#34;            CH.sub.2 CH.sub.2 SO.sub.2      
                                          NHCH.sub.2 CH.sub.2             
                                                           &#34;              
3-CHO-4-CH.sub.3   &#34;         &#34;            CH.sub.2 CH.sub.2               
                                                           &#34;              
3-CONH.sub.2 -5-C.sub.6 H.sub.4 -p-CH.sub.3                               
                   &#34;         &#34;            &#34;                &#34;              
3-CN-5-COOC.sub.2 H.sub.5                                                 
                   &#34;         &#34;            CH.sub.2 CH.sub.2 CONHC.sub.2   
                                          H.sub.4          &#34;              
3-COOCH.sub.3 -5-COCH(CH.sub.3).sub.2                                     
                   &#34;         &#34;            CH.sub.2 CH.sub.2 NHCOCH.sub.2  
                                                           &#34;              
&#34;                  &#34;         &#34;            CH.sub.2 CH.sub.2 NHSO.sub.2    
                                          CH.sub.2 CH.sub.2               
                                                           &#34;              
&#34;                  3-NHCOC.sub.6 H.sub.5                                  
                             &#34;            CH.sub.2 CH.sub.2               
                                                           &#34;              
&#34;                  3-NHCOOC.sub.2 H.sub.5                                 
                             &#34;            &#34;                &#34;              
&#34;                  3-CH.sub.3                                             
                             CH.sub.2 CH.sub.2 OSO.sub.3 Na               
                                          &#34;                Na.sup.+       
&#34;                  &#34;         C.sub.2 H.sub.5                              
                                          CH.sub.2 CH(OSO.sub.3 Na)CH.sub.
                                          2                &#34;              
__________________________________________________________________________
 
    
     
                                           TABLE 20                                
__________________________________________________________________________
 ##STR69##                                                                
Substituents on                                                           
 Ring G              (R.sub.1).sub.m                                      
                              R.sub.3                                     
                                   R.sub.4                                
                                           Z                M             
__________________________________________________________________________
3-CONHC.sub.2 H.sub.5 -5-COCH(CH.sub.3).sub.2                             
                   None       CH.sub.3                                    
                                  CH.sub.3                                
                                         CH.sub.2 CH.sub.2  K.sup.+       
&#34;                  &#34;          H   CH.sub.3                                
                                         &#34;                  &#34;             
3-CONH.sub.2 -5-COCH(CH.sub.3).sub.2                                      
                   7-CH.sub.3 &#34;   &#34;      &#34;                  &#34;             
&#34;                  &#34;          CH.sub.3                                    
                                  &#34;      &#34;                  &#34;             
&#34;                  7-CH.sub.3 H   CH(CH.sub.3).sub.2                      
                                         &#34;                  &#34;             
&#34;                  7-OCH.sub.3                                            
                              &#34;   CH.sub.3                                
                                         &#34;                  &#34;             
&#34;                  5-OCH.sub.3, 8-CH.sub.3                                
                              &#34;   &#34;      &#34;                  &#34;             
&#34;                  5,8-di-OCH.sub.3                                       
                              &#34;   &#34;      &#34;                  &#34;             
&#34;                  5,8-di-CH.sub.3                                        
                              &#34;   &#34;      &#34;                  &#34;             
&#34;                  7-Cl       &#34;   &#34;      &#34;                  &#34;             
&#34;                  5,8-di-Cl  &#34;   &#34;      &#34;                  &#34;             
3-COOCH.sub.3 -5-COCH(CH.sub.3).sub.2                                     
                   None       &#34;   &#34;      &#34;                  Na.sup.+      
&#34;                  5-OCH.sub.3, 8-CH.sub.3                                
                              CH.sub.3                                    
                                  &#34;      &#34;                  &#34;             
&#34;                  7-NHCHO    &#34;   &#34;      &#34;                  &#34;             
&#34;                  7-NHCOCH.sub.3                                         
                              &#34;   &#34;      &#34;                  &#34;             
&#34;                  7-NHCOCH.sub.2 OCH.sub.3                               
                              &#34;   &#34;      &#34;                  &#34;             
3,5-di-CN-4-CH.sub.3                                                      
                   7-NHCOOC.sub.2 H.sub.5                                 
                              &#34;   &#34;      &#34;                  &#34;             
&#34;                  7-NHCOC.sub.6 H.sub.5                                  
                              &#34;   &#34;      &#34;                  &#34;             
&#34;                  7-NHCONHC.sub.2 H.sub.5                                
                              &#34;   &#34;      &#34;                  K.sup.+       
&#34;                  7-NHCOC.sub.6 H.sub.11                                 
                              &#34;   &#34;      &#34;                  &#34;             
&#34;                  None       &#34;   &#34;      &#34;                  &#34;             
3-CONH.sub.2 -5-C.sub.6 H.sub.5                                           
                   7-CH.sub.3 H   &#34;      &#34;                  &#34;             
&#34;                  &#34;          &#34;   H      &#34;                  &#34;             
3-COOCH.sub.3 -5-C.sub.6 H.sub.5                                          
                   &#34;          &#34;   CH.sub.3                                
                                         &#34;                  &#34;             
3-COOCH.sub.3 -5-COCH.sub.3                                               
                   &#34;          &#34;   &#34;      &#34;                  &#34;             
3-CN-5-COOC.sub.2 H.sub.5                                                 
                   &#34;          &#34;   &#34;      &#34;                  &#34;             
3-CN-4-CH.sub.3 -5-COOC.sub.2 H.sub.5                                     
                   &#34;          &#34;   &#34;      &#34;                  &#34;             
3-CN-4-CH.sub.3 -5-COCH.sub.3                                             
                   &#34;          &#34;   &#34;      &#34;                  &#34;             
3-COOCH.sub.3 -4-CH.sub.3 -5-CN                                           
                   7-OCH.sub.3                                            
                              &#34;   &#34;      &#34;                  &#34;             
3-CN-4-CH.sub.3 -5-CO.sub.2 CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5            
                   7-CH.sub.3 &#34;   &#34;      &#34;                  &#34;             
3-SO.sub.2 C.sub.6 H.sub.5 -5-COCH.sub.3                                  
                   &#34;          &#34;   &#34;      &#34;                  &#34;             
3-SO.sub.2 C.sub.6 H.sub.4 -p-Cl-5-COCH.sub.3                             
                   &#34;          &#34;   &#34;      &#34;                  &#34;             
3-SO.sub.2 CH.sub.3 -5-CN                                                 
                   &#34;          &#34;   &#34;      &#34;                  &#34;             
3-COOCH.sub.3 -5-Br                                                       
                   &#34;          &#34;   &#34;      &#34;                  &#34;             
3-COOCH.sub.3 -5-SCN                                                      
                   &#34;          &#34;   &#34;      &#34;                  &#34;             
3-CONHC.sub.2 H.sub.4 OH-5-COCH(CH.sub.3).sub.2                           
                   None       &#34;   &#34;      &#34;                  &#34;             
3-CONHC.sub.3 H.sub.6 OCH.sub.3 -5-COCH(CH.sub.3).sub.2                   
                   &#34;          &#34;   &#34;      &#34;                  &#34;             
3-CN-5-SO.sub.2 CH.sub.3                                                  
                   &#34;          &#34;   &#34;      &#34;                  &#34;             
3,5-di-SO.sub.2 NH.sub.2                                                  
                   &#34;          &#34;   &#34;      &#34;                  &#34;             
3,5-di-SO.sub.2 NHC.sub.2 H.sub.5                                         
                   7-CH.sub.3 &#34;   &#34;      &#34;                  &#34;             
3-COOCH.sub.3 -5-COC.sub.6 H.sub.5                                        
                   &#34;          &#34;   &#34;      &#34;                  &#34;             
3-CONHC.sub.4 H.sub.9 -n-5-COC.sub.6 H.sub.5                              
                   &#34;          &#34;   &#34;      CH.sub.2 CH.sub.2 OCH.sub.2      
                                         CH.sub.2           &#34;             
3-COOCH.sub.3 -5-SO.sub.2 CH.sub.3                                        
                   &#34;          &#34;   &#34;      CH.sub.2 CH.sub.2 SCH.sub.2      
                                         CH.sub.2           &#34;             
3-CONHC.sub.2 H.sub.4 OH-5-SO.sub.2 CH.sub.3                              
                   &#34;          &#34;   &#34;      CH.sub.2 CH.sub.2 SO.sub.2       
                                         CH.sub.2 CH.sub.2  &#34;             
3-CHO              &#34;          &#34;   &#34;      CH.sub.2 CH.sub.2 N(SO.sub.2     
                                         CH.sub.3)CH.sub.2 CH.sub.2       
                                                            &#34;             
3-SO.sub.2 C.sub.6 H.sub.5                                                
                   &#34;          &#34;   &#34;      CH.sub.2 CH.sub.2 SO.sub.2       
                                         NHCH.sub.2 CH.sub.2              
                                                            &#34;             
3-CONHC.sub.2 H.sub.5 -5-COCH(CH.sub.3).sub.2                             
                   &#34;          &#34;   &#34;      CH.sub.2 CH.sub.2 CH.sub.2       
                                         NHCOCH.sub.2       &#34;             
&#34;                  &#34;          &#34;   &#34;      CH.sub.2 CH.sub.2 CONHCH.sub.2   
                                         CH.sub.2           &#34;             
&#34;                  &#34;          &#34;   &#34;      CH.sub.2 CH.sub.2 N(COC.sub.6    
                                         H.sub.5)CH.sub.2 CH.sub.2        
                                                            &#34;             
&#34;                  &#34;          &#34;   &#34;      CH.sub.2 CH.sub.2 (CH.sub.3)     
                                                            &#34;             
&#34;                  &#34;          &#34;   &#34;      CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2
                                                            Na.sup.+      
&#34;                  &#34;          &#34;   &#34;      CH.sub.2 CH(CH.sub.2 Cl)         
                                                            &#34;             
&#34;                  &#34;          &#34;   &#34;      CH.sub.2 CH(CH.sub.2 OCH.sub.3)  
                                                            &#34;             
&#34;                  &#34;          &#34;   &#34;      CH.sub.2 CH(C.sub.6 H.sub.5)     
                                                            &#34;             
&#34;                  &#34;          &#34;   &#34;      CH.sub.2 CH(CH.sub.2 OC.sub.6    
                                         H.sub.5)           &#34;             
3-COOCH.sub.3 -4CH.sub.3 -5-CONH.sub.2                                    
                   &#34;          &#34;   &#34;      CH.sub.2 CH.sub.2 CH.sub.2       
                                         N(CH.sub.3)SO.sub.2 CH.sub.2     
                                         CH.sub.2           &#34;             
&#34;                  &#34;          &#34;   &#34;      CH.sub.2 CH.sub.2 CH.sub.2       
                                                            &#34;             
__________________________________________________________________________
 
    
     
                                           TABLE 21                                
__________________________________________________________________________
 ##STR70##                                                                
Substituents on                                                           
Ring G             (R.sub.1).sub.m                                        
                             R.sub.3                                      
                                 Z                  M                     
__________________________________________________________________________
3-COOCH.sub.3 -5-COCH(CH.sub.3).sub.2                                     
                   None      H   CH.sub.2 CH.sub.2  Na.sup.+              
3-CONH.sub.2 -5-COCH(CH.sub.3).sub.2                                      
                   6-CH.sub.3                                             
                             &#34;   &#34;                  &#34;                     
3-CN-5-COCH(CH.sub.3).sub.2                                               
                   &#34;         3-CH.sub.3                                   
                                 &#34;                  &#34;                     
&#34;                  6-OCH.sub.3                                            
                             &#34;   &#34;                  &#34;                     
3-CONH.sub.2 -5-C.sub.6 H.sub.5                                           
                   &#34;         H   &#34;                  &#34;                     
&#34;                  6-CH.sub.3                                             
                             3-CH.sub.3                                   
                                 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      
                                                    &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2  &#34;                     
3-CN-5-C.sub.6 H.sub.5                                                    
                   &#34;         &#34;   &#34;                  &#34;                     
3-CONHC.sub.2 H.sub.4 OHOH-5-C.sub.6 H.sub.5                              
                   &#34;         &#34;   &#34;                  &#34;                     
3-CONHC.sub.2 H.sub.5 -5-COC.sub.6 H.sub.5                                
                   &#34;         &#34;   &#34;                  &#34;                     
3-CONHCH.sub.3 -5-COC.sub.6 H.sub.5                                       
                   &#34;         &#34;   &#34;                  &#34;                     
3-CN-4-CH.sub.3 -5-COOC.sub.2 H.sub.5                                     
                   &#34;         &#34;   &#34;                  &#34;                     
3-CN-4-CH.sub.3 -5-COOC.sub.2 H.sub.4 OCH.sub.3                           
                   &#34;         &#34;   &#34;                  &#34;                     
3-CHO-4,5-di-CH.sub. 3                                                    
                   &#34;         &#34;   &#34;                  &#34;                     
3-CN-4-CH.sub.3 -5-SCH.sub.3                                              
                   6-NHCOCH.sub.3                                         
                             &#34;   &#34;                  K.sup.+               
3-COOCH.sub.3 -4-CH.sub.3 -5-CONH.sub.2                                   
                   6-NHCOC.sub.6 H.sub.5                                  
                             &#34;   &#34;                  &#34;                     
3-CONH.sub.2 -4-CH.sub.3 -5-CN                                            
                   6-NHCOC.sub.4 H.sub.9 -n                               
                             &#34;   &#34;                  &#34;                     
3,5-di-CN-4-CH.sub. 3                                                     
                   6-NHCONHC.sub.2 H.sub.5                                
                             &#34;   &#34;                  &#34;                     
&#34;                  6-NHCOCH.sub.2 OCH.sub.3                               
                             &#34;   &#34;                  &#34;                     
&#34;                  6-NHCOCH.sub.2 CN                                      
                             &#34;   &#34;                  &#34;                     
&#34;                  6-CH.sub.3                                             
                             &#34;   &#34;                  Na.sup. +             
3-CONH.sub.2 -4-CH.sub.3 -5-COOCH.sub.3                                   
                   &#34;         &#34;   &#34;                  &#34;                     
3-SO.sub.2 CH.sub.3 -5-COCH.sub.3                                         
                   &#34;         &#34;   &#34;                  &#34;                     
3-SO.sub.2 C.sub.6 H.sub.5 -5-COCH.sub.3                                  
                   &#34;         &#34;   &#34;                  &#34;                     
3-SO.sub.2 C.sub.6 H.sub.4 -p-Cl-5-COCH.sub. 3                            
                   &#34;         &#34;   &#34;                  &#34;                     
3-SO.sub.2 CH.sub.3 -5-Br                                                 
                   &#34;         &#34;   &#34;                  &#34;                     
3,5-di-SO.sub.2 CH.sub.3                                                  
                   &#34;         &#34;   &#34;                  &#34;                     
3,5-di-SO.sub.2 NH.sub.2                                                  
                   &#34;         &#34;   &#34;                  &#34;                     
3,5-di-SO.sub.2 NHC.sub.2 H.sub.5                                         
                   &#34;         &#34;   &#34;                  &#34;                     
3-CONHC.sub.2 H.sub.4 OH-5-COCH(CH.sub.3).sub.2                           
                   6-NHCHO   &#34;   &#34;                  &#34;                     
3-CONHC.sub.3 H.sub.6 OCH.sub.3 -5-COCH(CH.sub.3).sub.2                   
                   6-CH.sub.3                                             
                             &#34;   &#34;                  &#34;                     
3-CONHC.sub.2 H.sub.4 NHCOCH.sub.3                                        
                   &#34;         &#34;   &#34;                  &#34;                     
3-CONHC.sub.4 H.sub.9 -n-5-C.sub.6 H.sub.5                                
                   &#34;         &#34;   &#34;                  &#34;                     
3-CN-5-COOC.sub.2 H.sub.5                                                 
                   &#34;         &#34;   &#34;                  &#34;                     
3-CN-4-CH.sub.3 -5-COOCH(CH.sub.3).sub.2                                  
                   &#34;         &#34;   &#34;                  &#34;                     
3-CN-4-CH.sub.3SCONHC.sub.2 H.sub.5                                       
                   &#34;         &#34;   &#34;                  &#34;                     
3-CN-4-CH.sub.3 -5-CONHC.sub.6 H.sub.5                                    
                   &#34;         &#34;   &#34;                  &#34;                     
3-CONH.sub.2 -5-SO.sub.2 CH.sub.3                                         
                   &#34;         &#34;   &#34;                  &#34;                     
3-CONH.sub.2 -5-COCH(CH.sub.3).sub.2                                      
                   &#34;         &#34;   CH.sub.2 CH(CH.sub.3)                    
                                                    &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH(C.sub.6 H.sub.5)             
                                                    &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH(CH.sub.2 Cl)                 
                                                    &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH(OSO.sub.3 K)CH.sub.2         
                                                    &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)   
                                                    &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2     
                                                    &#34;                     
3-CONHC.sub.2 H.sub.5 -5-COCH(CH.sub.3).sub.2                             
                   &#34;         &#34;   CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2     
                                                    &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2      
                                 CH.sub.2           &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.
                                 sub.2 CH.sub.2     &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2 N(SO.sub.2 C.sub.6     
                                 H.sub.5)CH.sub.2 CH.sub.2                
                                                    &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2 SO.sub.2 N(CH.sub.3)CH.
                                 sub.2 CH.sub.2     &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2 NHCOCH.sub.2           
                                                    &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2 CH.sub.2 NHSO.sub.2    
                                 CH.sub.2 CH.sub.2  &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2  
                                                    &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2  
                                 CH.sub.2 CH.sub.2  &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2 SO.sub.2 N(C.sub.6     
                                 H.sub.5)CH.sub.2 CH.sub.2                
                                                    &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2 NHCONHCH.sub.2         
                                                    &#34;H.sub.2              
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2 CH.sub.2               
                                                    &#34;                     
&#34;                  &#34;         &#34;   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2SCH.su
                                 b.2 CH.sub.2       &#34;                     
__________________________________________________________________________
 
    
     Although the invention has been described in considerable detail with particular reference to certain preferred embodiments thereof, variations and modifications can be effected within the spirit and scope of the invention.