Patent Publication Number: US-2023151060-A1

Title: Cyclic peptide compound having kras inhibitory action

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application is a U.S. National Phase of PCT Application No. PCT/JP2020/041277, filed Nov. 5, 2020, which claims the benefit of Japanese Patent Application No. 2019-202407, filed Nov. 7, 2019, each of which is incorporated herein by reference in its entirety. 
    
    
     TECHNICAL FIELD 
     The present invention relates to cyclic peptide compounds having Kras inhibitory action, non-natural amino acids for use in the production of cyclic peptide compounds, and production methods therefor. 
     BACKGROUND ART 
     Ras is a protein belonging to the small GTPase family, and Kras, Nras, and Hras are known. Ras is in an inactive state or an active state according to whether it is bound to GTP or GDP. It is activated by the exchange reaction from GDP to GTP by GEFs (guanine nucleotide exchange factors) and inactivated by the hydrolysis reaction of GTP by GAPs (GTPase-activating proteins) (NPL 1). Activated Ras induces cell proliferation, survival, and differentiation by activating various downstream signals in the MAPK pathway, PI3K/Akt pathway, RAL pathway, and such, and the constitutive activation of Ras plays an important role in the development and progression of cancer. In cancer, it is known that the Ras-RAF-MEK-ERK pathway is activated by the activation of an upstream signal of Ras, constitutive activation of Ras, and/or activating mutations of Ras (NPL 2). These activating mutations of Ras have been found in numerous cancer types. G12, G13, and Q61 are known as hot spots of Ras mutation, and G12 is frequently found mutated in Kras and Q61 in Nras. These mutations are also known to be associated with the prognosis of patients (NPL 3). 
     When it comes to access to a tough target, as typified by inhibition of a protein-protein interaction, medium sized molecules (having a molecular weight of 500 to 2000) may be superior to low molecular weight compounds. Also, medium sized molecules may be superior to antibodies in that they can migrate into cells. Among biologically active medium sized molecules, peptide drugs are highly valuable molecular species, with more than 40 peptide drugs being already commercially available (NPL 4). Representative examples of such peptide drugs include cyclosporin A and polymyxin B, which are peptides containing some non-natural amino acids. A non-natural amino acid refers to an amino acid that is not naturally encoded on mRNA. It is highly interesting that non-natural amino acids that are not encoded on mRNA are contained in naturally-occurring cyclosporin A and polymyxin B. 
     Since the discovery of the pharmaceutical utility of naturally-occurring peptides, peptides having pharmacological activity and bioabsorbability have been attracting attention, and those having a molecular weight of about 500 to 2000 have been actively researched (NPL 5). 
     There is a report on conditions for medium molecular weight peptides to have increased membrane permeability and metabolic stability, which may contribute to improving their biokinetics (conditions necessary for satisfying drug-likeness) (PTL 1). 
     Moreover, as for the conditions that may contribute to improving the biokinetics of medium molecular weight peptides, conditions necessary for cyclic peptides to satisfy drug-likeness have been shown (PTL 2). 
     Peptides that bind to Ras have been found, and the binding site between a cyclic peptide and Ras has been studied by X-ray structural analysis (NPL 6, NPL 7, and NPL 8). Also, cyclic peptides that apparently inhibit binding between Ras and SOS have been found (PTL 3). Moreover, a competition assay for binding with Ras has suggested that some cyclic peptides inhibit binding between a particular compound and Ras (PTL 4). 
     CITATION LIST 
     Patent Literature 
     
         
         [PTL 1] WO 2013/100132 
         [PTL 2] WO 2018/225864 
         [PTL 3] WO 2012/122059 
         [PTL 4] WO 2017/181061 
       
    
     Non-Patent Literature 
     
         
         [NPL 1] Nat. Rev. Drug Discov. 2014 November; 13(11):828-851. 
         [NPL 2] Nat. Rev. Drug Discov. 2014 December; 13(12):928-942. 
         [NPL 3] Nat. Rev. Drug Discov. 2016 November; 15(11):771-785. 
         [NPL 4] Future Med. Chem. 2009, 1, 1289-1310. 
         [NPL 5] Current Topics in Medicinal Chemistry, 2013, Vol. 13, No. 7, 821-836. 
         [NPL 6] Biochem. Biophys. Res. Commun. 2017, 484, 605-611. 
         [NPL 7] Bioorg. Med. Chem. Lett. 2017, 27, 2757-2761. 
         [NPL 8] ACS Med. Chem. Lett. 2017, 8, 732-736. 
       
    
     SUMMARY OF INVENTION 
     Technical Problem 
     The present invention provides compounds effective for Ras-mutant cancer and non-natural amino acids useful for the production thereof. 
     PTL 1 and PTL 2 describe drug-like peptides, but do not describe a peptide having an antitumor effect on cancers including Ras-mutant cancer. 
     PTL 3 describes the inhibition of binding between Ras and SOS, and PTL 4 describes a peptide competing with a compound that binds to Ras. However, none of these documents shows any pharmacological action, especially action on tumor cells. These documents do not describe drug-like peptides, either. 
     NPL 1 shows the relationship between Ras and cancer in detail. This document describes molecules that bind to Ras. Although their efficacy was shown in preclinical studies, no compound was shown to be effective as a drug specifically on Ras-mutant cancer. Also, no drug-like cyclic peptide is disclosed. 
     NPL 2 provides detailed descriptions about Ras and the RAF-MEK-ERK pathway, which is downstream of Ras. Although this document suggests the possibility of treating Ras-mutant cancer with RAF, MEK, and ERK inhibitors, it does not show any compound that directly inhibits Ras. 
     NPL 3 describes a compound that binds to the GTP/GDP binding site of Ras and inhibits the function of Ras, and the mechanism thereof. This document describes the interaction with the GTP/GDP binding site in detail, but does not show pharmacological action, especially action on tumor cells. 
     NPL 4 describes peptides that are used as drugs, but does not describe a drug-like peptide or a peptide useful for Ras-mutant cancer. 
     NPL 5 describes the molecular form and pharmacokinetics of cyclic peptides, but does not describe a compound useful for Ras-mutant cancer. 
     NPLs 6 to 8 describe peptides that bind to Ras, but their action on tumor cells is limited, and, in addition, a drug-like peptide is not described. 
     Despite the fact that Ras-mutant cancer has no effective treatment and the unmet need is strong, a drug that directly inhibits Ras and exhibits a clinical therapeutic effect has not been developed yet. Also, a peptide that satisfies drug-likeness has not been found. 
     The peptide compounds of interest in the present invention are breakthrough drugs that directly bind to Ras and inhibit its interaction with SOS, whereby they suppress the activation of Ras and inhibit the proliferation of cancer cells having Ras mutation. 
     Solution to Problem 
     As a result of dedicated research for seeking cyclic peptide compounds having Ras inhibitory activity, the present inventors found cyclic peptide compounds that interact with Ras. The inventors also found that those cyclic peptide compounds inhibit the binding between Ras and SOS. In addition, the inventors found specific non-natural amino acids contained in the cyclic peptide compounds and methods for production thereof. The inventors found that the cyclic peptide compounds have, as a pharmacological effect, a proliferation inhibitory effect on tumor cells having Ras mutation. 
     The present invention encompasses the following in one non-limiting specific embodiment: 
     [1] A cyclic peptide compound represented by formula (1) below or a salt thereof, or a solvate thereof: 
     
       
         
         
             
             
         
       
     
     wherein, 
     L 1  is a single bond, or —CHM 1 -, —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m —, or —(CH 2 ) n S(O) 2 (CH 2 ) m —, wherein n and m are each independently 1 or 2, 
     R 1  is hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, or C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4-to 8-membered cyclic amino), and C 1 -C 6  alkylsulfonyl, or 
     R 1  and P 1 , together with the carbon atom to which R 1  is attached and the nitrogen atom to which P 1  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 1  and Q 1 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     R 1  and M 1 , together with the carbon atom to which R 1  is attached and the carbon atom to which M 1  is attached, form a 3- to 8-membered alicyclic ring, 
     except when R 1  and P 1  form a 4- to 7-membered saturated heterocyclic ring, P 1  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 1  and Q 1  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 1  is hydrogen or C 1 -C 6  alkyl, and 
     except when R 1  and M 1  form a 3- to 8-membered alicyclic ring, M 1  is hydrogen, 
     R 2  is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, or C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, cyano, and C 1 -C 6  alkylsulfonyl, or 
     R 2  and P 2 , together with the carbon atom to which R 2  is attached and the nitrogen atom to which P 2  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 2  and Q 2 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or except when R 2  and P 2  form a 4- to 7-membered saturated heterocyclic ring, P 2  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 2  and Q 2  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 2  is hydrogen or C 1 -C 6  alkyl, 
     R 3  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, or C 7 -C 14  aralkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of hydroxy and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), or 
     R 3  and P 3 , together with the carbon atom to which R 3  is attached and the nitrogen atom to which P 3  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 3  and Q 3 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 3  and P 3  form a 4- to 7-membered saturated heterocyclic ring, P 3  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, or C 3 -C 8  cycloalkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and C 1 -C 6  aminoalkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, wherein the 4- to 8-membered cyclic amino is optionally substituted with one or more halogens), 
     except when R 3  and Q 3  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 3  is hydrogen or C 1 -C 6  alkyl, 
     R 4  is hydrogen or C 1 -C 6  alkyl, or 
     R 4  and P 4 , together with the carbon atom to which R 4  is attached and the nitrogen atom to which P 4  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 4  and Q 4 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 4  and P 4  form a 4- to 7-membered saturated heterocyclic ring, P 4  is hydrogen, C 1 -C 6  alkyl, or C 1 -C 6  alkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 4  and Q 4  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 4  is hydrogen or C 1 -C 6  alkyl, 
     R 5  is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl, C 6 -C 10  aryloxyC 1 -C 6  alkyl, C 7 -C 14  aralkoxyC 1 -C 6  alkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, cyano, and C 1 -C 6  alkylsulfonyl, or R 5  together with R 8  forms C 4 -C 8  alkylene, or 
     R 5  and P 5 , together with the carbon atom to which R 5  is attached and the nitrogen atom to which P 5  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 5  and Q 5 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 5  and P 5  form a 4- to 7-membered saturated heterocyclic ring, P 5  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 5  and Q 5  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 5  is hydrogen or C 1 -C 6  alkyl, 
     R 6  is hydrogen or C 1 -C 6  alkyl, or 
     R 6  and P 6 , together with the carbon atom to which R 6  is attached and the nitrogen atom to which P 6  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 6  and Q 6 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 6  and P 6  form a 4- to 7-membered saturated heterocyclic ring, P 6  is C 1 -C 6  alkyl or C 3 -C 8  cycloalkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 6  and Q 6  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 6  is hydrogen or C 1 -C 6  alkyl, 
     R 7  is C 6 -C 10  aryloxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl, C 7 -C 14  aralkoxyC 1 -C 6  alkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, cyano, C 1 -C 6  alkylsulfonyl, and SF 5 , or 
     R 7  and P 7 , together with the carbon atom to which R 7  is attached and the nitrogen atom to which P 7  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 7  and Q 7 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 7  and P 7  form a 4- to 7-membered saturated heterocyclic ring, P 7  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 7  and Q 7  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 7  is hydrogen or C 1 -C 6  alkyl, 
     R 8  is hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 2 -C 6  alkenyloxycarbonylC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 6 -C 10  aryloxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl, C 7 -C 14  aralkoxyC 1 -C 6  alkyl, 5- to 10-membered heteroarylC 1 -C 6  alkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, carboxy, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, cyano, amino (wherein the amino is —NH 2 , protected amino, mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), 4- to 7-membered heterocycloalkylidene, protected 4- to 7-membered heterocycloalkylidene, 4- to 7-membered heterocyclyl, and protected 4- to 7-membered heterocyclyl, or R 8  together with R 5  forms C 4 -C 5  alkylene, or 
     R 8  and P 8 , together with the carbon atom to which R 8  is attached and the nitrogen atom to which P 8  is attached, form a 4- to 7-membered saturated heterocyclic ring, wherein the 4- to 7-membered saturated heterocyclic ring is optionally fused with a saturated carbon ring or an aromatic ring, the 4- to 7-membered saturated heterocyclic ring is optionally substituted with halogen, oxo, C 6 -C 10  aryl, 5- to 10-membered heteroaryl, 4- to 8-membered cyclic amino (wherein the cyclic amino is optionally substituted with one or more halogens), or OS 8 , and S 8  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 7 -C 14  aralkyl (wherein the aralkyl is optionally substituted with one or more halogens, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, or C 1 -C 6  haloalkoxy), or 5- to 10-membered heteroarylC 1 -C 6  alkyl, or 
     R 8  and Q 8 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 8  and P 8  form a 4- to 7-membered saturated heterocyclic ring, P 8  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 1 -C 6  alkoxyC 2 -C 6  alkenyl, C 3 -C 8  cycloalkyl, 4- to 7-membered heterocyclyl, 4- to 7-membered heterocyclylC 1 -C 6  alkyl, C 6 -C 10  aryl, C 7 -C 14  aralkyl, 5- to 10-membered heteroaryl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen or C 1 -C 6  alkyl), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 8  and Q 8  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 8  is hydrogen or C 1 -C 6  alkyl, 
     R 9  is hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 7 -C 14  aralkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), and C 1 -C 6  alkylsulfonyl, or 
     R 9  and P 9 , together with the carbon atom to which R 9  is attached and the nitrogen atom to which P 9  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 9  and Q 9 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 9  and P 9  form a 4- to 7-membered saturated heterocyclic ring, P 9  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 9  and Q 9  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 9  is hydrogen or C 1 -C 6  alkyl, R 10  is C 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, or C 7 -C 14  aralkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, and C 1 -C 6  alkylsulfonyl, or 
     R 10  and P 10 , together with the carbon atom to which R 10  is attached and the nitrogen atom to which P 10  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 10  and Q 10 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 10  and P 10  form a 4- to 7-membered saturated heterocyclic ring, P 10  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 10  and Q 10  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 10  is hydrogen or C 1 -C 6  alkyl, and 
     L 11  is a single bond, or —CHM 11 -, —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m —, or —(CH 2 ) n S(O) 2 (CH 2 ) m —, wherein n and m are each independently 1 or 2, 
     R 11  is hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl, or aminocarbonyl (wherein the amino is —NH 2 , mono C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, oxo, hydroxy, C 1 -C 6  alkyl, 4- to 7-membered heterocyclyl, aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), and C 1 -C 6  alkylsulfonyl, or R 11  is a peptide chain comprising 1 to 4 amino acid residues, or 
     R 11  and P 11 , together with the carbon atom to which R 11  is attached and the nitrogen atom to which P 11  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 11  and Q 11 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     R 11  and M 11 , together with the carbon atom to which R 11  is attached and the carbon atom to which M 11  is attached, form a 3- to 8-membered alicyclic ring, 
     except when R 11  and P 11  form a 4- to 7-membered saturated heterocyclic ring, P 11  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 11  and Q 11  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 11  is hydrogen or C 1 -C 6  alkyl, 
     except when R 11  and M 11  form a 3- to 8-membered alicyclic ring, M 11  is hydrogen, 
     wherein, when L 1  is a single bond, L 11  is —CHM 11 -, —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m —, or —(CH 2 ) n S(O) 2 (CH 2 ) m —, and when L 1  is —CHM 1 -, —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m —, or —(CH 2 ) n S(O) 2 (CH 2 ) m —, L 11  is a single bond, and 
     at least three of P 1  to P 11  are not hydrogen. 
     [2] The cyclic peptide compound, or salt thereof, or solvate thereof according to [1], wherein the compound is represented by formula (2) below: 
     
       
         
         
             
             
         
       
     
     wherein, 
     R 1  is C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkylsulfonylC 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with one or more halogens, aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), or hydroxy), C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, or C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, or 
     R 1  and P 1 , together with the nitrogen atom to which P 1  is attached and the carbon atom to which R 1  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 1  and P 1  form a 4- to 7-membered saturated heterocyclic ring, P 1  is hydrogen or C 1 -C 6  alkyl, 
     R 2  is C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkylsulfonylC 1 -C 6  alkyl, C 1 -C 6  cyanoalkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, or C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, 
     P 2  is hydrogen, 
     R 3  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino) or hydroxy), aminocarbonylC 1 -C 6  alkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, or C 7 -C 14  aralkyl, or 
     R 3  and P 3 , together with the nitrogen atom to which P 3  is attached and the carbon atom to which R 3  is attached, form a 4- to 7-membered saturated heterocyclic ring, 
     except when R 3  and P 3  form a 4- to 7-membered saturated heterocyclic ring, P 3  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 1 -C 6  aminoalkyl (wherein the amino is —NH 2 , protected amino, mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogens), or C 3 -C 8  cycloalkyl, 
     R 4  is hydrogen or C 1 -C 6  alkyl, or 
     R 4  and P 4  together with the nitrogen atom to which P 4  is attached and the carbon atom to which R 4  is attached form a 4- to 7-membered saturated heterocyclic ring, 
     except when R 4  and P 4  form a 4- to 7-membered saturated heterocyclic ring, P 4  is C 1 -C 6  alkyl or C 1 -C 6  alkoxyC 1 -C 6  alkyl, 
     R 5  is C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 2 -C 6  alkenyl, C 1 -C 6  alkylsulfonylC 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl (wherein the C 7 -C 14  aralkyl is optionally substituted with one or more halogens, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, or cyano), C 6 -C 10  aryloxyC 1 -C 6  alkyl optionally substituted with one or more halogens, C 7 -C 14  aralkoxyC 1 -C 6  alkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl, or R 5  together with R 8  forms C 4 -C 5  alkylene, 
     P 5  is hydrogen or C 1 -C 6  alkyl, 
     R 6  is hydrogen or C 1 -C 6  alkyl, or 
     R 6  and P 6 , together with the nitrogen atom to which P 6  is attached and the carbon atom to which R 6  is attached, form a 4- to 7-membered saturated heterocyclic ring, 
     except when R 6  and P 6  form a 4- to 7-membered saturated heterocyclic ring, P 6  is C 1 -C 6  alkyl or C 3 -C 8  cycloalkyl, 
     R 7  is C 6 -C 10  aryloxyC 1 -C 6  alkyl (wherein the C 6 -C 10  aryloxyC 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen and C 1 -C 6  haloalkyl), C 7 -C 14  aralkyl (wherein the C 7 -C 14  aralkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 2 -C 6  alkynyl, cyano, C 1 -C 6  alkylsulfonyl, and SF 5 ), C 7 -C 14  aralkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, or 5- to 10-membered heteroarylC 1 -C 6  alkyl (wherein the 5- to 10-membered heteroarylC 1 -C 6  alkyl is optionally substituted with one or more halogens, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, or C 1 -C 6  alkoxy), 
     Q 7  is hydrogen or C 1 -C 6  alkyl, 
     P 7  is hydrogen, 
     R 8  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  carboxyalkyl, C 1 -C 6  aminoalkyl (wherein the amino is —NH 2 , protected amino, mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogens), aminocarbonylC 1 -C 6  alkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogens), optionally protected 4- to 7-membered heterocyclylC 1 -C 6  alkyl, optionally protected 4- to 7-membered heterocycloalkylidene C 1 -C 6  alkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino) or hydroxy), C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkenyloxycarbonylC 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 6 -C 10  aryloxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl (wherein the C 7 -C 14  aralkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, and cyano), 5- to 10-membered heteroarylalkyl (wherein the 5- to 10-membered heteroarylalkyl is optionally substituted with one or more groups selected from the group consisting of C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, and cyano), or 5- to 10-membered heteroarylC 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, or R 8  together with R 5  forms C 4 -C 5  alkylene, or 
     R 8  and P 8 , together with the nitrogen atom to which P 8  is attached and the carbon atom to which R 8  is attached, form a 4- to 7-membered saturated heterocyclic ring, wherein the 4- to 7-membered saturated heterocyclic ring is optionally fused with a 3- to 8-membered saturated carbon ring or a 6- to 10-membered aromatic ring, and the 4- to 7-membered saturated heterocyclic ring is optionally substituted with one or more halogens, hydroxy, oxo, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  hydroxyalkoxy, C 6 -C 10  aryl, 5- to 10-membered heteroarylC 1 -C 6  alkoxy, C 7 -C 14  aralkoxy (wherein the C 7 -C 14  aralkoxy is optionally substituted with one or more halogens, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, or C 1 -C 6  haloalkoxy), 4- to 8-membered cyclic amino optionally substituted with one or more halogens, or 5- to 10-membered heteroaryl, or 
     except when R 8  and P 8  form a 4- to 7-membered saturated heterocyclic ring, P 8  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with one or more halogens, hydroxy, di-C 1 -C 6  alkylaminocarbonyl, C 1 -C 6  alkoxy, or amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino)), aminocarbonylC 1 -C 6  alkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogens), C 1 -C 6  aminoalkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogens or C 1 -C 6  alkyl), C 2 -C 6  alkenyl, C 2 -C 6  hydroxyalkenyl, aminocarbonylC 2 -C 6  alkenyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), C 1 -C 6  alkoxyC 2 -C 6  alkenyl, C 3 -C 8  cycloalkyl optionally substituted with one or more halogens, 4- to 7-membered heterocyclyl, 4- to 7-membered heterocyclylC 1 -C 6  alkyl, C 6 -C 10  aryl optionally substituted with one or more halogens, C 7 -C 14  aralkyl, 5- to 10-membered heteroaryl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl, 
     R 9  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkenyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), hydroxy, or 5- to 10-membered heteroaryl optionally substituted with one or more halogens), C 3 -C 8  cycloalkylC 1 -C 6  alkyl, or C 7 -C 14  aralkyl (wherein the C 7 -C 14  aralkyl is optionally substituted with one or more groups independently selected from the group consisting of halogens, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, and cyano), or 
     R 9  and Q 9 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     R 9  and P 9 , together with the nitrogen atom to which P 9  is attached and the carbon atom to which R 9  is attached, form a 4- to 7-membered saturated heterocyclic ring, 
     except when R 9  and Q 9  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 9  is hydrogen or C 1 -C 6  alkyl, 
     except when R 9  and P 9  form a 4- to 7-membered saturated heterocyclic ring, P 9  is hydrogen or C 1 -C 6  alkyl, R 10  is C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkylsulfonylC 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, or C 7 -C 14  aralkyl, or R 10  and P 10 , together with the nitrogen atom to which P 10  is attached and the carbon atom to which R 10  is attached, form a 4- to 7-membered saturated heterocyclic ring, 
     except when R 10  and P 10  form a 4- to 7-membered saturated heterocyclic ring, P 10  is hydrogen or C 1 -C 6  alkyl, 
     R 11  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with hydroxy or aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino)), C 7 -C 14  aralkyl optionally substituted with one or more halogens, or aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6 alkylamino, or 4- to 8-membered cyclic amino, wherein the cyclic amino is optionally further substituted with one or more halogens, one or more oxo, one or more C 1 -C 6  alkyl, or 4- to 7-membered heterocyclyl), or 
     R 11  and M 11 , together with the carbon atom to which R 11  is attached and the carbon atom to which M 11  is attached, form a 3- to 8-membered alicyclic ring, 
     R 11  and P 1 , together with the nitrogen atom to which P 11  is attached and the carbon atom to which R 11  is attached, form a 4- to 7-membered saturated heterocyclic ring, 
     except when R 11  and M 11  form a 3- to 8-membered alicyclic ring, M 11  is hydrogen, 
     except when R 11  and P 11  form a 4- to 7-membered saturated heterocyclic ring, P 11  is hydrogen or C 1 -C 6  alkyl. 
     [3] The cyclic peptide compound or salt thereof, or solvate thereof according to any one of [1] and [2], wherein 
     R 11  is —CONR 11A R 11B , wherein 
     R 11A  and R 11B  are each independently hydrogen or C 1 -C 6  alkyl, or R 11A  and R 11B , together with the nitrogen atom to which they are attached, form a 4- to 8-membered saturated heterocyclic ring, wherein the 4- to 8-membered saturated heterocyclic ring is optionally substituted with one or more groups independently selected from the group consisting of halogen, oxo, C 1 -C 6  alkyl, and 4- to 7-membered heterocyclyl. [4] The cyclic peptide compound or salt thereof, or solvate thereof according to any one of [1] to [3], wherein 
     R 7  is —(CH 2 ) x —O y —(CH 2 ) z1 —C 6 -C 10  aryl or —(CH 2 ) x —O y —(CH 2 ) z2 -5- to 10-membered heteroaryl optionally substituted with one to five groups independently selected from the group consisting of halogen, C 1 -C 4  alkyl, C 2 -C 4  alkynyl, C 1 -C 3  haloalkyl, C 1 -C 3  haloalkoxy, C 1 -C 4  alkoxy, —CN, C 1 -C 3  alkylsulfonyl, hydroxy, and SF 5 , wherein 
     x is 1, 2, or 3, 
     y is 0 or 1, 
     z1 is 0, 1, 2, or 3, and 
     z2 is 1, 2, or 3, 
     provided that the sum of x, y, and z1 or z2 is 1 to 4. 
     [5] The cyclic peptide compound or salt thereof, or solvate thereof according to any one of [1] to [4], wherein 
     R 4  and P 4 , together with the nitrogen atom to which P 4  is attached and the carbon atom to which R 4  is attached, form a 4- to 7-membered saturated heterocyclic ring. 
     [6] The cyclic peptide compound or salt thereof, or solvate thereof according to any one of [1] to [5], wherein 
     R 8  and P 8 , together with the nitrogen atom to which P 8  is attached and the carbon atom to which R 8  is attached, form a 4- to 7-membered saturated heterocyclic ring. 
     [7] The cyclic peptide compound or salt thereof, or solvate thereof according to any one of [1] to [6], wherein 
     R 8  is —(CH 2 ) x —O y —(CH 2 ) z1 —C 6 -C 10  aryl or —(CH 2 ) x —O y —(CH 2 ) z2 -5- to 10-membered heteroaryl optionally substituted with one to five groups independently selected from the group consisting of halogen, C 1 -C 4  alkyl, C 2 -C 4  alkynyl, C 1 -C 3  haloalkyl, C 1 -C 3  haloalkoxy, C 1 -C 4  alkoxy, —CN, C 1 -C 3  alkylsulfonyl, hydroxy, and SF 5 , wherein 
     x is 1, 2, or 3, 
     y is 0 or 1, 
     z1 is 0, 1, 2, or 3, and 
     z2 is 1, 2, or 3, 
     provided that the sum of x, y, and z1 or z2 is 1 to 4. 
     [8] The cyclic peptide compound or salt thereof, or solvate thereof according to any one of [1] to [7], wherein 
     R 9  is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, or C 7 -C 14  aralkyl, and Q 9  is C 1 -C 6  alkyl, or 
     R 9  and Q 9  together with the carbon atom to which they are attached form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring. 
     [9] The cyclic peptide compound or salt thereof, or solvate thereof according to any one of [1] to [8], wherein at least three of P 1 , P 3  to P 6 , and P 8  to P 11  are alkyl.
 
[10] The cyclic peptide compound or salt thereof, or solvate thereof according to any one of [1] to [9], wherein R 2  and R 3  are C 1 -C 6  alkyl.
 
[11] The cyclic peptide compound or salt thereof, or solvate thereof according to [1], wherein the compound is represented by formula (3) below:
 
     
       
         
         
             
             
         
       
     
     wherein, 
     R 1  is hydrogen or C 1 -C 6  alkyl, 
     P 1  is hydrogen or C 1 -C 6  alkyl, 
     M 1  is hydrogen, 
     R 2  is C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkylsulfonylC 1 -C 6  alkyl, C 1 -C 6  cyanoalkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, or C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, 
     P 2  is hydrogen, 
     R 3  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino) or hydroxy), aminocarbonylC 1 -C 6  alkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, or C 7 -C 14  aralkyl, or 
     R 3  and P 3 , together with the nitrogen atom to which P 3  is attached and the carbon atom to which R 3  is attached, form a 4- to 7-membered saturated heterocyclic ring, 
     except when R 3  and P 3  form a 4- to 7-membered saturated heterocyclic ring, P 3  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  aminoalkyl (wherein the amino is —NH 2 , protected amino, mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogens), or C 3 -C 8  cycloalkyl, 
     R 4  is hydrogen or C 1 -C 6  alkyl, or 
     R 4  and P 4 , together with the nitrogen atom to which P 4  is attached and the carbon atom to which R 4  is attached, form a 4- to 7-membered saturated heterocyclic ring, 
     except when R 4  and P 4  form a 4- to 7-membered saturated heterocyclic ring, P 4  is C 1 -C 6  alkyl or C 1 -C 6  alkoxyC 1 -C 6  alkyl, 
     R 5  is C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 2 -C 6  alkenyl, C 1 -C 6  alkylsulfonylC 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl (wherein the C 7 -C 14  aralkyl is optionally substituted with one or more halogens, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, or cyano), C 6 -C 10  aryloxyC 1 -C 6  alkyl optionally substituted with one or more halogens, C 7 -C 14  aralkoxyC 1 -C 6  alkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl, or R 5  together with R 8  forms C 4 -C 8  alkylene, 
     P 5  is hydrogen or C 1 -C 6  alkyl, 
     R 6  is hydrogen or C 1 -C 6  alkyl, or 
     R 6  and P 6 , together with the nitrogen atom to which P 6  is attached and the carbon atom to which R 6  is attached, form a 4- to 7-membered saturated heterocyclic ring, 
     except when R 6  and P 6  form a 4- to 7-membered saturated heterocyclic ring, P 6  is C 1 -C 6 alkyl or C 3 -C 8  cycloalkyl, 
     R 7  is C 6 -C 10  aryloxyC 1 -C 6  alkyl (wherein the C 6 -C 10  aryloxyC 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen and C 1 -C 6  haloalkyl), C 7 -C 14  aralkyl (wherein the C 7 -C 14  aralkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 2 -C 6  alkynyl, cyano, C 1 -C 6  alkylsulfonyl, and SF 5 ), C 7 -C 14  aralkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, or 5- to 10-membered heteroarylC 1 -C 6  alkyl (wherein the 5- to 10-membered heteroarylC 1 -C 6  alkyl may be substituted with one or more halogens, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, or C 1 -C 6  alkoxy), 
     Q 7  is hydrogen or C 1 -C 6  alkyl, 
     P 7  is hydrogen, 
     R 8  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  carboxyalkyl, C 1 -C 6  aminoalkyl (wherein the amino is —NH 2 , protected amino, mono-C 1 -C 6  alkylamino, di-C 1 -C 6 alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogens), C 1 -C 6  aminocarbonylC 1 -C 6  alkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogens), optionally protected 4- to 7-membered heterocyclylC 1 -C 6  alkyl, optionally protected 4- to 7-membered heterocycloalkylideneC 1 -C 6  alkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino) or hydroxy), C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkenyloxycarbonylC 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 6 -C 10  aryloxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl (wherein the C 7 -C 14  aralkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, and cyano), 5- to 10-membered heteroarylalkyl (wherein the 5- to 10-membered heteroarylalkyl is optionally substituted with one or more groups selected from the group consisting of C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, and cyano), or 5- to 10-membered heteroarylC 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, or R 8  together with R 5  forms C 4 -C 8  alkylene, or 
     R 8  and P 8 , together with the nitrogen atom to which P 8  is attached and the carbon atom to which R 8  is attached, form a 4- to 7-membered saturated heterocyclic ring, wherein the 4- to 7-membered saturated heterocyclic ring is optionally fused with a 3- to 8-membered saturated carbon ring or a 6- to 10-membered aromatic ring, and the 4- to 7-membered saturated heterocyclic ring is optionally substituted with one or more halogens, hydroxy, oxo, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  hydroxyalkoxy, C 6 -C 10  aryl, 5- to 10-membered heteroarylC 1 -C 6  alkoxy, C 7 -C 14  aralkoxy (wherein the C 7 -C 14  aralkoxy is optionally substituted with one or more halogens, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, or C 1 -C 6  haloalkoxy), 4- to 8-membered cyclic amino optionally substituted with one or more halogens, or 5- to 10-membered heteroaryl, or 
     except when R 8  and P 8  form a 4- to 7-membered saturated heterocyclic ring, P 8  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with one or more halogens, hydroxy, di-C 1 -C 6  alkylaminocarbonyl, or C 1 -C 6  alkoxy), aminocarbonylC 1 -C 6  alkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogens), C 1 -C 6  aminoalkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogens), C 2 -C 6  alkenyl, C 2 -C 6  hydroxyalkenyl, aminocarbonylC 2 -C 6  alkenyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), C 1 -C 6  alkoxyC 2 -C 6  alkenyl, C 3 -C 8  cycloalkyl optionally substituted with one or more halogens, 4- to 7-membered heterocyclyl, 4- to 7-membered heterocyclylC 1 -C 6  alkyl, C 6 -C 10  aryl optionally substituted with one or more halogens, C 7 -C 14  aralkyl, 5- to 10-membered heteroaryl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl, 
     R 9  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkenyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino) or hydroxy), C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 7 -C 14  aralkyl (wherein the C 7 -C 14  aralkyl is optionally substituted with one or more groups independently selected from the group consisting of halogens, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, and cyano), or 5- to 10-membered heteroarylC 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, or 
     R 9  and Q 9 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     R 9  and P 9 , together with the nitrogen atom to which P 9  is attached and the carbon atom to which R 9  is attached, form a 4- to 7-membered saturated heterocyclic ring. 
     except when R 9  and Q 9  form a 4- to 7-membered saturated heterocyclic ring, Q 9  is hydrogen or C 1 -C 6  alkyl, 
     except when R 9  and P 9  form a 4- to 7-membered saturated heterocyclic ring, P 9  is hydrogen or C 1 -C 6  alkyl, 
     R 10  is C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkylsulfonylC 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, or C 7 -C 14  aralkyl, or 
     R 10  and P 10 , together with the nitrogen atom to which P 10  is attached and the carbon atom to which R 10  is attached, form a 4- to 7-membered saturated heterocyclic ring, 
     except when R 10  and P 10  form a 4- to 7-membered saturated heterocyclic ring, P 10  is hydrogen or C 1 -C 6  alkyl, 
     R 11  is hydrogen, C 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with hydroxy, or C 7 -C 14  aralkyl optionally substituted with one or more halogens, and P 11  is hydrogen or C 1 -C 6  alkyl. 
     A cyclic peptide compound represented by formula (1′) below or a salt thereof, or a solvate thereof: 
     
       
         
         
             
             
         
       
     
     wherein, 
     R 2  is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, or C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, cyano, and C 1 -C 6  alkylsulfonyl, or 
     R 2  and P 2 , together with the carbon atom to which R 2  is attached and the nitrogen atom to which P 2  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 2  and Q 2 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 2  and P 2  form a 4- to 7-membered saturated heterocyclic ring, P 2  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 2  and Q 2  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 2  is hydrogen or C 1 -C 6  alkyl, 
     R 3  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, or C 7 -C 14  aralkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of hydroxy and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), or 
     R 3  and P 3 , together with the carbon atom to which R 3  is attached and the nitrogen atom to which P 3  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 3  and Q 3 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 3  and P 3  form a 4- to 7-membered saturated heterocyclic ring, P 3  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, or C 3 -C 8  cycloalkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and C 1 -C 6  aminoalkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, wherein the 4- to 8-membered cyclic amino is optionally substituted with one or more halogens), 
     except when R 3  and Q 3  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 3  is hydrogen or C 1 -C 6  alkyl, 
     R 4  is hydrogen or C 1 -C 6  alkyl, or 
     R 4  and P 4 , together with the carbon atom to which R 4  is attached and the nitrogen atom to which P 4  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 4  and Q 4 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 4  and P 4  form a 4- to 7-membered saturated heterocyclic ring, P 4  is hydrogen, C 1 -C 6  alkyl, or C 1 -C 6  alkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 4  and Q 4  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 4  is hydrogen or C 1 -C 6  alkyl, 
     R 5  is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl, C 6 -C 10  aryloxyC 1 -C 6  alkyl, C 7 -C 14  aralkoxyC 1 -C 6  alkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, cyano, and C 1 -C 6  alkylsulfonyl, or R 5  together with R 8  forms C 4 -C 8  alkylene, or 
     R 5  and P 5 , together with the carbon atom to which R 5  is attached and the nitrogen atom to which P 5  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 5  and Q 5 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 5  and P 5  form a 4- to 7-membered saturated heterocyclic ring, P 5  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 5  and Q 5  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 5  is hydrogen or C 1 -C 6  alkyl, 
     R 6  is hydrogen or C 1 -C 6  alkyl, or 
     R 6  and P 6 , together with the carbon atom to which R 6  is attached and the nitrogen atom to which P 6  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 6  and Q 6 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 6  and P 6  form a 4- to 7-membered saturated heterocyclic ring, P 6  is C 1 -C 6  alkyl or C 3 -C 8  cycloalkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 6  and Q 6  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 6  is hydrogen or C 1 -C 6  alkyl, 
     R 7  is C 6 -C 10  aryloxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl, C 7 -C 14  aralkoxyC 1 -C 6  alkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, cyano, C 1 -C 6  alkylsulfonyl, and SF 5 , or 
     R 7  and P 7 , together with the carbon atom to which R 7  is attached and the nitrogen atom to which P 7  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 7  and Q 7 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 7  and P 7  form a 4- to 7-membered saturated heterocyclic ring, P 7  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 7  and Q 7  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 7  is hydrogen or C 1 -C 6  alkyl, 
     R 8  is hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 2 -C 6  alkenyloxycarbonylC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 6 -C 10  aryloxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl, C 7 -C 14  aralkoxyC 1 -C 6  alkyl, 5- to 10-membered heteroarylC 1 -C 6  alkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, carboxy, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, cyano, amino (wherein the amino is —NH 2 , protected amino, mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), 4- to 7-membered heterocycloalkylidene, protected 4- to 7-membered heterocycloalkylidene, 4- to 7-membered heterocyclyl, and protected 4- to 7-membered heterocyclyl, or R 8  together with R 5  forms C 4 -C 8  alkylene, or 
     R 8  and P 8 , together with the carbon atom to which R 8  is attached and the nitrogen atom to which P 8  is attached, form a 4- to 7-membered saturated heterocyclic ring, wherein the 4- to 7-membered saturated heterocyclic ring is optionally fused with a saturated carbon ring or an aromatic ring, the 4- to 7-membered saturated heterocyclic ring is optionally substituted with halogen, oxo, C 6 -C 10  aryl, 5- to 10-membered heteroaryl, 4- to 8-membered cyclic amino (wherein the cyclic amino is optionally substituted with one or more halogens), or OS 8 , and S 8  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 7 -C 14  aralkyl (wherein the aralkyl is optionally substituted with one or more halogens, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, or C 1 -C 6  haloalkoxy), or 5- to 10-membered heteroarylC 1 -C 6  alkyl, or 
     R 8  and Q 8 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 8  and P 8  form a 4- to 7-membered saturated heterocyclic ring, P 8  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 1 -C 6  alkoxyC 2 -C 6  alkenyl, C 3 -C 8  cycloalkyl, 4- to 7-membered heterocyclyl, 4- to 7-membered heterocyclylC 1 -C 6  alkyl, C 6 -C 10  aryl, C 7 -C 14  aralkyl, 5- to 10-membered heteroaryl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen or C 1 -C 6  alkyl), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 8  and Q 8  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 8  is hydrogen or C 1 -C 6  alkyl, 
     R 9  is hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 7 -C 14  aralkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), and C 1 -C 6  alkylsulfonyl, or 
     R 9  and P 9 , together with the carbon atom to which R 9  is attached and the nitrogen atom to which P 9  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 9  and Q 9 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 9  and P 9  form a 4- to 7-membered saturated heterocyclic ring, P 9  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 9  and Q 9  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 9  is hydrogen or C 1 -C 6  alkyl, R 10  is C 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, or C 7 -C 14  aralkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, and C 1 -C 6  alkylsulfonyl, or 
     R 10  and P 10 , together with the carbon atom to which R 10  is attached and the nitrogen atom to which P 10  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 10  and Q 10 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     except when R 10  and P 10  form a 4- to 7-membered saturated heterocyclic ring, P 10  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 10  and Q 10  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 10  is hydrogen or C 1 -C 6  alkyl, and 
     L 11  is —CHMn 11 —, —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m —, or —(CH 2 ) n S(O) 2 (CH 2 ) m —, wherein n and m are each independently 1 or 2, 
     R 11  is hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl, or aminocarbonyl (wherein the amino is —NH 2 , mono C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, oxo, hydroxy, C 1 -C 6  alkyl, 4- to 7-membered heterocyclyl, aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), and C 1 -C 6  alkylsulfonyl, or R 11  is a peptide chain comprising 1 to 4 amino acid residues, or 
     R 11  and P 11 , together with the carbon atom to which R 11  is attached and the nitrogen atom to which P 11  is attached, form a 4- to 7-membered saturated heterocyclic ring, or 
     R 11  and Q 11 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, or 
     R 11  and M 11 , together with the carbon atom to which R 11  is attached and the carbon atom to which M 11  is attached, form a 3- to 8-membered alicyclic ring, 
     except when R 11  and P 11  form a 4- to 7-membered saturated heterocyclic ring, P 11  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), 
     except when R 11  and Q 11  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 11  is hydrogen or C 1 -C 6  alkyl, 
     except when R 11  and M 11  form a 3- to 8-membered alicyclic ring, M 11  is hydrogen, and at least three of P 2  to P 11  are not hydrogen. 
     [13] The cyclic peptide compound or salt thereof, or solvate thereof according to [1] or [12], wherein the compound is selected from the group consisting of cyclic peptide compounds set forth in Table 24.
 
[14] A pharmaceutical composition comprising the cyclic peptide compound or salt thereof, or solvate thereof according to any one of [1] to [13].
 
[15] An amino acid set forth in Table 5 or Table 6 or a salt thereof, or a solvate thereof.
 
[16] An inhibitor of binding between Kras and SOS, comprising an effective amount of the cyclic peptide compound or salt thereof, or solvate thereof according to any one of [1] to [13].
 
[17] A pharmaceutical composition for treating or preventing cancer in a subject, the pharmaceutical composition comprising an effective amount of the cyclic peptide compound or salt thereof, or solvate thereof according to any one of [1] to [13].
 
[18] The pharmaceutical composition according to [17], wherein the cancer is pancreatic cancer.
 
[19] The pharmaceutical composition according to any one of [17] to [18], wherein the subject is a human.
 
     Effects of the Invention 
     The present invention can provide novel cyclic peptide compounds having anti-tumor action, non-natural amino acids for use in the production of the cyclic peptide compounds, and production methods therefor. 
     DESCRIPTION OF EMBODIMENTS 
     Abbreviations 
     The abbreviations used herein are as follows. 
     AA: Ammonium acetate 
     Alloc group: Allyloxycarbonyl group 
     Boc group: tert-Butoxycarbonyl group 
     Cbz group: Benzyloxycarbonyl group 
     CSA: (+)-10-Camphorsulfonic acid 
     DBU: 1,8-Diazabicyclo[5.4.0]-7-undecene 
     DCC: N,N′-Dicyclohexylcarbodiimide 
     DCM: Dichloromethane 
     DCE: 1,2-Dichloroethane 
     DEAD: Diethyl azodicarboxylate 
     DMA: Dimethylacetamide 
     DMF: N,N-Dimethylformamide 
     DIAD: Diisopropyl azodicarboxylate 
     DIC: N,N′-Diisopropylcarbodiimide 
     DIPEA: N,N-Diisopropylethylamine 
     DMAP: N,N-Dimethyl-4-aminopyridine 
     t-Bu group: tert-Butyl group 
     dtbbpy: 4,4′-Di-tert-butyl-2,2′-dipyridyl 
     EDTA: Ethylenediaminetetraacetic acid 
     FA: Formic acid 
     Fmoc group: 9-Fluorenylmethyloxycarbonyl group 
     NMP: N-Methyl-2-pyrrolidone 
     TBME: t-Butyl methyl ether 
     TES: Triethylsilane 
     TFA: Trifluoroacetic acid 
     TFE: 2,2,2-Trifluoroethanol 
     THF: Tetrahydrofuran 
     THP: Tetrahydropyranyl 
     TMSCl: Trimethylsilyl chloride 
     HFIP: 1,1,1,3,3,3-Hexafluoroisopropyl alcohol 
     HOAt: 1-Hydroxy-7-azabenzotriazole 
     HOBt: 1-Hydroxybenzotriazole 
     HOOBt: 3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine 
     IPAC: Isopropyl acetate 
     oxyma: Ethyl cyano(hydroxyimino)acetate 
     PPTS: Pyridinium p-toluenesulfonate 
     Pis: 2-Phenylisopropyl 
     WSCI.HCl: 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride 
     TIPS: Triisopropylsilane 
     TfOH: Trifluoromethanesulfonic acid 
     HATU: 0-(7-Aza-1H-benzotriazole-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate 
     DMSO: Dimethylsulfoxide 
     Fmoc-Cl: (9H-Fluoren-9-yl)methyl carbonochloridate 
     Fmoc-OSu: 9-Fluorenylmethyl N-succinimidyl carbonate 
     Ns group: o-Nitrobenzenesulfonyl group 
     Trt group: Triphenylmethyl group 
     Troc group: 2,2,2-Trichloroethoxycarbonyl group 
     (Definitions of Functional Groups and the Like) 
     Examples of “halogen atoms” herein include F, Cl, Br, and I. 
     “Alkyl” herein means a monovalent group derived by removing any one hydrogen atom from an aliphatic hydrocarbon, and has a subset of hydrocarbyl or hydrocarbon group structures not containing either a heteroatom (which refers to an atom other than carbon and hydrogen atoms) or an unsaturated carbon-carbon bond but containing hydrogen and carbon atoms in its backbone. The alkyl includes linear and branched alkyls. Specifically, the alkyl has 1 to 20 carbon atoms (C 1 -C 20 , hereinafter “C p -C q ” means that the number of carbon atoms is p to q), and is preferably C 1 -C 10  alkyl, and more preferably C 1 -C 6  alkyl. Specific examples of alkyl include methyl, ethyl, n-propyl, i-propyl, n-butyl, s-butyl, t-butyl, isobutyl (2-methylpropyl), n-pentyl, s-pentyl (1-methylbutyl), t-pentyl (1,1-dimethylpropyl), neopentyl (2,2-dimethylpropyl), isopentyl (3-methylbutyl), 3-pentyl (1-ethylpropyl), 1,2-dimethylpropyl, 2-methylbutyl, n-hexyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1,1,2,2-tetramethylpropyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, and 2-ethylbutyl. 
     “Alkenyl” herein means a monovalent group having at least one double bond (two adjacent SP 2  carbon atoms). Depending on the configuration of a double bond and a substituent (if present), the geometrical form of the double bond can be entgegen (E) or zusammen (Z) as well as cis or trans configuration. The alkenyl includes linear and branched alkenyls. The alkenyl is preferably C 2 -C 10  alkenyl, and more preferably C 2 -C 6  alkenyl, and specific examples include vinyl, allyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl (including cis and trans forms), 3-butenyl, pentenyl, 3-methyl-2-butenyl, and hexenyl. 
     “Alkynyl” herein means a monovalent group having at least one triple bond (two adjacent SP carbon atoms). The alkynyl includes linear and branched alkynyls. The alkynyl is preferably C 2 -C 10  alkynyl, and more preferably C 2 -C 6  alkynyl, and specific examples include ethynyl, 1-propynyl, propargyl, 3-butynyl, pentynyl, hexynyl, 3-phenyl-2-propynyl, 3-(2′-fluorophenyl)-2-propynyl, 2-hydroxy-2-propynyl, 3-(3-fluorophenyl)-2-propynyl, and 3-methyl-(5-phenyl)-4-pentynyl. 
     “Cycloalkyl” herein means a saturated or partially saturated cyclic monovalent aliphatic hydrocarbon group and includes a monocyclic ring, a bicyclo ring, and a spiro ring. The cycloalkyl is preferably C 3 -C 8  cycloalkyl, and specific examples include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, bicyclo[2.2.1]heptyl, and spiro[3.3]heptyl. 
     “Aryl” herein means a monovalent aromatic hydrocarbon ring, and is preferably C 6 -C 10  aryl. Specific examples of the aryl include phenyl and naphthyl (e.g., 1-naphthyl and 2-naphthyl). 
     “Heterocyclyl” herein means a non-aromatic cyclic monovalent group containing 1 to 5 hetero atoms in addition to carbon atoms. The heterocyclyl may have a double and/or triple bond within the ring, a carbon atom within the ring may be oxidized to form carbonyl, and heterocyclyl may be a monocyclic ring or a condensed ring. The number of atoms constituting the ring is preferably 4 to 10 (4- to 10-membered heterocyclyl), and more preferably 4 to 7 (4- to 7-membered heterocyclyl). Specific examples of the heterocyclyl include azetidinyl, oxiranyl, oxetanyl, azetidinyl, dihydrofuryl, tetrahydrofuryl, dihydropyranyl, tetrahydropyranyl, tetrahydropyridyl, tetrahydropyrimidyl, morpholinyl, thiomorpholinyl, pyrrolidinyl, piperidinyl, piperazinyl, pyrazolidinyl, imidazolinyl, imidazolidinyl, oxazolidinyl, isoxazolidinyl, thiazolidinyl, isothiazolidinyl, 1,2-thiazinane, thiadiazolidinyl, azetidinyl, oxazolidone, benzodioxanyl, benzoxazolyl, dioxolanyl, dioxanyl, tetrahydropyrrolo[1,2-c]imidazole, thietanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3-oxa-8-azabicyclo[3.2.1]octanyl, sultam, and 2-oxaspiro[3.3]heptyl. 
     “Protected heterocyclyl” herein means a group in which one or more functional groups, such as an amino group, contained in the above-defined “heterocyclyl” are protected with a protecting group, and is preferably 4- to 7-membered protected heterocyclyl. Specific examples of the protecting group include Boc, Fmoc, Cbz, Troc, and Alloc, and specific examples of the protected heterocyclyl include Boc-protected azetidine. 
     “Heterocycloalkylidene” herein means a divalent group obtained by removing two hydrogen atoms from one carbon atom of the above-defined “heterocyclyl”, in which a free valence forms a part of a double bond. The heterocycloalkylidene is preferably 4- to 7-membered heterocycloalkylidene, and specific examples include tetrahydropyran-4-ylidene and azetidin-3-ylidene. 
     “Protected heterocycloalkylidene” herein means a group in which one or more functional groups, such as an amino group, contained in the above-defined “heterocycloalkylidene” are protected with a protecting group, and is preferably 4- to 7-membered protected heterocycloalkylidene. Specific examples of the protecting group include Boc, Fmoc, Cbz, Troc, and Alloc, and specific examples of the protected heterocycloalkylidene include Boc-protected azetidin-3-ylidene. 
     “Heteroaryl” herein means an aromatic cyclic monovalent group containing 1 to 5 heteroatoms in addition to carbon atoms. The ring may be a monocyclic ring, may be a condensed ring formed with another ring, or may be partially saturated. The number of atoms constituting the ring is preferably 5 to 10 (5- to 10-membered heteroaryl) and more preferably 5 to 7 (5- to 7-membered heteroaryl). Specific examples of the heteroaryl include furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiadiazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, triazinyl, benzofuranyl, benzothienyl, benzothiadiazolyl, benzothiazolyl, benzoxazolyl, benzoxadiazolyl, benzoimidazolyl, indolyl, isoindolyl, indazolyl, quinolyl, isoquinolyl, cinnolinyl, quinazolinyl, quinoxalinyl, benzodioxolyl, indolizinyl, and imidazopyridyl. 
     “Alkoxy” herein means an oxy group to which the above-defined “alkyl” is bonded, and is preferably C 1 -C 6  alkoxy. Specific examples of the alkoxy include methoxy, ethoxy, 1-propoxy, 2-propoxy, n-butoxy, i-butoxy, s-butoxy, t-butoxy, pentyloxy, and 3-methylbutoxy. 
     “Alkenyloxy” herein means an oxy group to which the above-defined “alkenyl” is bonded, and is preferably C 2 -C 6  alkenyloxy. Specific examples of the alkenyloxy include vinyloxy, allyloxy, 1-propenyloxy, 2-propenyloxy, 1-butenyloxy, 2-butenyloxy (including cis and trans forms), 3-butenyloxy, pentenyloxy, and hexenyloxy. 
     “Cycloalkoxy” herein means an oxy group to which the above-defined “cycloalkyl” is bonded, and is preferably C 3 -C 8  cycloalkoxy. Specific examples of the cycloalkoxy include cyclopropoxy, cyclobutoxy, and cyclopentyloxy. 
     “Aryloxy” herein means an oxy group to which the above-defined “aryl” is bonded, and is preferably C 6 -C 10  aryloxy. Specific examples of the aryloxy include phenoxy, 1-naphthyloxy, and 2-naphthyloxy. 
     “Amino” herein means —NH 2  in a narrow sense and —NRR′ in a broad sense, wherein R and R′ are independently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, or R and R′, together with the nitrogen atom to which they are attached, form a ring. The amino is preferably —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, 4- to 8-membered cyclic amino, or the like. 
     “Monoalkylamino” herein means a group corresponding to the above-defined “amino” wherein R is hydrogen and R′ is the above-defined “alkyl”, and is preferably mono-C 1 -C 6  alkylamino. Specific examples of the monoalkylamino include methylamino, ethylamino, n-propylamino, i-propylamino, n-butylamino, s-butylamino, and t-butylamino. 
     “Dialkylamino” herein means a group corresponding to the above-defined “amino” wherein R and R′ are independently the above-defined “alkyl”, and is preferably di-C 1 -C 6  alkylamino. Specific examples of the dialkylamino include dimethylamino and diethylamino. 
     “Cyclic amino” herein means a group corresponding to the above-defined “amino” wherein R and R′, together with the nitrogen atom to which they are attached, form a ring, and is preferably 4- to 8-membered cyclic amino. Specific examples of the cyclic amino include 1-azetidyl, 1-pyrrolidyl, 1-piperidyl, 1-piperazyl, 4-morpholinyl, 3-oxazolidyl, 1,1-dioxidethiomorpholinyl-4-yl, and 3-oxa-8-azabicyclo[3.2.1]octan-8-yl. 
     “Protected amino” herein means an amino group protected with any protecting group. Specific examples of the protected amino include amino protected with a protecting group such as Boc, Fmoc, Cbz, Troc, or Alloc. 
     “Aminocarbonyl” herein means a carbonyl group to which the above-defined “amino” is bonded, and is preferably —CONH 2 , mono-C 1 -C 6  alkylaminocarbonyl, di-C 1 -C 6  alkylaminocarbonyl, and 4- to 8-membered cyclic aminocarbonyl. Specific examples of the aminocarbonyl include —CONH 2 , dimethylaminocarbonyl, 1-azetidinylcarbonyl, 1-pyrrolidinylcarbonyl, 1-piperidinylcarbonyl, 1-piperazinylcarbonyl, 4-morpholinylcarbonyl, 3-oxazolidinylcarbonyl, 1,1-dioxidethiomorpholinyl-4-ylcarbonyl, and 3-oxa-8-azabicyclo[3.2.1]octan-8-ylcarbonyl. 
     “Alkenyloxycarbonyl” herein means a carbonyl group to which the above-defined “alkenyloxy” is bonded, and is preferably C 2 -C 6  alkenyloxycarbonyl. Specific examples of the alkenyloxycarbonyl include vinyloxycarbonyl, allyloxycarbonyl, 1-propenyloxycarbonyl, 2-propenyloxycarbonyl, 1-butenyloxycarbonyl, 2-butenyloxycarbonyl (including cis and trans forms), 3-butenyloxycarbonyl, pentenyloxycarbonyl, and hexenyloxycarbonyl. 
     “Alkylsulfonyl” herein means a sulfonyl group to which the above-defined “alkyl” is bonded, and is preferably C 1 -C 6  alkylsulfonyl. Specific examples of the alkylsulfonyl include methylsulfonyl. 
     “Hydroxyalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with hydroxyl groups, and is preferably C 1 -C 6  hydroxyalkyl. Specific examples of the hydroxyalkyl include hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2-hydroxy-2-methylpropyl, and 5-hydroxypentyl. 
     “Haloalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with halogen, and is preferably C 1 -C 6  haloalkyl, and more preferably C 1 -C 6  fluoroalkyl. Specific examples of the haloalkyl include difluoromethyl, trifluoromethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 3,3-difluoropropyl, 4,4-difluorobutyl, and 5,5-difluoropentyl. 
     “Cyanoalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with cyano, and is preferably C 1 -C 6  cyanoalkyl. Specific examples of the cyanoalkyl include cyanomethyl and 2-cyanoethyl. 
     “Aminoalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with the above-defined “amino”, and is preferably C 1 -C 6  aminoalkyl. Specific examples of the aminoalkyl include 1-pyridylmethyl, 2-(1-piperidyl)ethyl, 3-(1-piperidyl)propyl, and 4-aminobutyl. 
     “Carboxyalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with carboxy, and is preferably C 2 -C 6  carboxyalkyl. Specific examples of the carboxyalkyl include carboxymethyl. 
     “Alkenyloxycarbonylalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with the above-defined “alkenyloxycarbonyl”, and is preferably C 2 -C 6  alkenyloxycarbonyl C 1 -C 6  alkyl, and more preferably C 2 -C 6  alkenyloxycarbonyl C 1 -C 2  alkyl. Specific examples of the alkenyloxycarbonylalkyl include allyloxycarbonylmethyl and 2-(allyloxycarbonyl)ethyl. 
     “Alkoxyalkyl” herein means a group in which one of more hydrogens of the above-defined “alkyl” are replaced with the above-defined “alkoxy”, and is preferably C 1 -C 6  alkoxy C 1 -C 6  alkyl, and more preferably C 1 -C 6  alkoxy C 1 -C 2  alkyl. Specific examples of the alkoxyalkyl include methoxymethyl, ethoxymethyl, 1-propoxymethyl, 2-propoxymethyl, n-butoxymethyl, 1-butoxymethyl, s-butoxymethyl, t-butoxymethyl, pentyloxymethyl, 3-methylbutoxymethyl, 1-methoxyethyl, 2-methoxyethyl, and 2-ethoxyethyl. 
     “Cycloalkylalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with the above-defined “cycloalkyl”, and is preferably C 3 -C 8  cycloalkyl C 1 -C 6  alkyl, and more preferably C 3 -C 6  cycloalkyl C 1 -C 2  alkyl. Specific examples of the cycloalkylalkyl include cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, and cyclohexylmethyl. 
     “Cycloalkoxylalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with the above-defined “cycloalkoxy”, and is preferably C 3 -C 8  cycloalkoxy C 1 -C 6  alkyl, and more preferably C 3 -C 6  cycloalkoxy C 1 -C 2  alkyl. Specific examples of the cycloalkoxyalkyl include cyclopropoxymethyl and cyclobutoxymethyl. 
     “Heterocyclylalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with the above-defined “heterocyclyl”, and is preferably 4- to 7-membered heterocyclyl C 1 -C 6  alkyl, and more preferably 4- to 7-membered heterocyclyl C 1 -C 2  alkyl. Specific examples of the heterocyclylalkyl include 2-(tetrahydro-2H-pyran-4-yl)ethyl and 2-(azetidin-3-yl)ethyl. 
     “Alkylsulfonylalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with the above-defined “alkylsulfonyl”, and is preferably C 1 -C 6 alkylsulfonyl C 1 -C 6  alkyl, and more preferably C 1 -C 6  alkylsulfonyl C 1 -C 2  alkyl. Specific examples of the alkylsulfonylalkyl include methylsulfonylmethyl and 2-(methylsulfonyl)ethyl. 
     “Aminocarbonylalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with the above-defined “aminocarbonyl”, and is preferably aminocarbonyl C 1 -C 6  alkyl, and more preferably aminocarbonyl C 1 -C 4  alkyl. Specific examples of the aminocarbonylalkyl include methylaminocarbonylmethyl, dimethylaminocarbonylmethyl, t-butylaminocarbonylmethyl, 1-azetidinylcarbonylmethyl, 1-pyrrolidinylcarbonylmethyl, 1-piperidinylcarbonylmethyl, 4-morpholinylcarbonylmethyl, 2-(methylaminocarbonyl)ethyl, 2-(dimethylaminocarbonyl)ethyl, 2-(1-azetidinylcarbonyl)ethyl, 2-(1-pyrrolidinylcarbonyl)ethyl, 2-(4-morpholinylcarbonyl)ethyl, 3-(dimethylaminocarbonyl)propyl, and 4-(dimethylaminocarbonyl)butyl. 
     “Aryloxyalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with the above-defined “aryloxy”, and is preferably C 6 -C 10  aryloxy C 1 -C 6  alkyl, and more preferably C 6 -C 10  aryloxy C 1 -C 2  alkyl. Specific examples of the aryloxyalkyl include phenoxymethyl and 2-phenoxyethyl. 
     “Aralkyl (arylalkyl)” herein means a group in which one or more hydrogen atoms of the above-defined “alkyl” are replaced with the above-defined “aryl”, and is preferably C 7 -C 14  aralkyl, and more preferably C 7 -C 10  aralkyl. Specific examples of the aralkyl include benzyl, phenethyl, and 3-phenylpropyl. 
     “Aralkoxy” herein means an oxy group to which the above-defined “aralkyl” is bonded, and is preferably C 7 -C 14  aralkoxy, and more preferably C 7 -C 10  aralkoxy. Specific examples of the aralkoxy include benzyloxy, phenethyloxy, and 3-phenylpropoxy. 
     “Aralkoxyalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with the above-defined “aralkoxy”, and is preferably C 7 -C 14  aralkoxy C 1 -C 6  alkyl, and more preferably C 7 -C 14  aralkoxy C 1 -C 2  alkyl. Specific examples of the aralkoxyalkyl include benzyloxymethyl and 1-(benzyloxy)ethyl. 
     “Heteroarylalkyl” herein means a group in which one or more hydrogen atoms of the above-defined “alkyl” are replaced with the above-defined “heteroaryl”, and is preferably 5- to 10-membered heteroaryl C 1 -C 6  alkyl, and more preferably 5- to 10-membered heteroaryl C 1 -C 2  alkyl. Specific examples of the heteroarylalkyl include 3-thienylmethyl, 4-thiazolylmethyl, 2-pyridylmethyl, 3-pyridylmethyl, 4-pyridylmethyl, 2-(2-pyridyl)ethyl, 2-(3-pyridyl)ethyl, 2-(4-pyridyl)ethyl, 2-(6-quinolyl)ethyl, 2-(7-quinolyl)ethyl, 2-(6-indolyl)ethyl, 2-(5-indolyl)ethyl, and 2-(5-benzofuranyl)ethyl. 
     “Heteroarylalkoxy” herein means an oxy group to which the above-defined “heteroarylalkyl” is bonded, and is preferably 5- to 10-membered heteroaryl C 1 -C 6  alkoxy, and more preferably 5- to 10-membered heteroarylC 1 -C 2  alkoxy. Specific examples of the heteroarylalkoxy include 3-thienylmethoxy and 3-pyridylmethoxy. 
     “Heteroarylalkoxyalkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with the above-defined “heteroarylalkoxy”, and is preferably 5- to 10-membered heteroaryl C 1 -C 6  alkoxy C 1 -C 6  alkyl, and more preferably 5- to 10-membered heteroaryl C 1 -C 2  alkoxy C 1 -C 2  alkyl. Specific examples of the heteroarylalkoxyalkyl include 3-pyridylmethoxymethyl. 
     “Heterocycloalkylidenealkyl” herein means a group in which one or more hydrogens of the above-defined “alkyl” are replaced with the above-defined “heterocycloalkylidene”, and is preferably 4- to 7-membered heterocycloalkylidene C 1 -C 6  alkyl, and more preferably 4- to 7-membered heterocycloalkylidene C 1 -C 2  alkyl. Specific examples of the heterocycloalkylidenealkyl include tetrahydro-4H-pyran-4-ylidenemethyl and azetidin-3-ylidenemethyl. 
     “Alkoxyalkenyl” herein means a group in which one or more hydrogens of the above-defined “alkenyl” are replaced with the above-defined “alkoxy”, and is preferably C 1 -C 6  alkoxy C 2 -C 6  alkenyl. Specific examples of the alkoxyalkenyl include (E)-4-methoxybut-2-en-1-yl. 
     “Aminocarbonylalkenyl” herein means a group in which one or more hydrogens of the above-defined “alkenyl” are replaced with the above-defined “aminocarbonyl”, and is preferably aminocarbonyl C 2 -C 6  alkenyl. Specific examples of the aminocarbonylalkenyl include (E)-3-(dimethylaminocarbonylcarbonyl)-prop-2-en-1-yl. 
     “Haloalkoxy” herein means a group in which one or more hydrogens of the above-defined “alkoxy” are replaced with halogen, and is preferably C 1 -C 6  haloalkoxy. Specific examples of the haloalkoxy include difluoromethoxy, trifluoromethoxy, 2,2-difluoroethoxy, and 2,2,2-trifluoroethoxy. 
     “Alkylene” herein means a divalent group derived by further removing any one hydrogen atom from the above “alkyl”, and is preferably C 4 -C 8  alkylene. Specific examples of the alkylene include —CH 2 —, —(CH 2 ) 2 —, —(CH 2 ) 3 —, —CH(CH 3 )CH 2 —, —C(CH 3 ) 2 —, —(CH 2 ) 4 —, —CH(CH 3 )CH 2 CH 2 —, —C(CH 3 ) 2 CH 2 —, —CH 2 CH(CH 3 )CH 2 —, —CH 2 C(CH 3 ) 2 —, —CH 2 CH 2 CH(CH 3 )—, —(CH 2 ) 5 —, —(CH 2 ) 6 —, —(CH 2 ) 7 —, and —(CH 2 ) 8 —. 
     “Alicyclic ring” herein means a non-aromatic hydrocarbon ring. The alicyclic ring may have an unsaturated bond within the ring, and may be a polycyclic ring having two or more rings. A carbon atom constituting the ring may be oxidized to form carbonyl. The alicyclic ring is preferably a 3- to 8-membered alicyclic ring, and specific examples include a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, a cyclohexane ring, a cycloheptane ring, a cyclooctane ring, and a bicyclo[2.2.1]heptane ring. 
     “Saturated heterocyclic ring” herein means a non-aromatic heterocyclic ring containing 1 to 5 hetero atoms in addition to carbon atoms and not containing a double bond and/or a triple bond within the ring. The saturated heterocyclic ring may be a monocyclic ring, or may form a condensed ring with another ring, e.g., an aromatic ring such as a benzene ring. When the saturated heterocyclic ring forms a condensed ring, the saturated heterocyclic ring is preferably a 4- to 7-membered saturated heterocyclic ring, and specific examples include an azetidine ring, an oxetane ring, a tetrahydrofuran ring, a tetrahydropyran ring, a morpholine ring, a thiomorpholine ring, a pyrrolidine ring, a 4-oxopyrrolidine ring, a piperidine ring, a 4-oxopiperidine ring, a piperazine ring, a pyrazolidine ring, an imidazolidine ring, an oxazolidine ring, an isoxazolidine ring, a thiazolidine ring, an isothiazolidine ring, a thiadiazolidine ring, an oxazolidone ring, a dioxolane ring, a dioxane ring, a thietane ring, an octahydroindole ring, and an indoline ring. 
     “Peptide chain” herein refers to a peptide chain in which 1, 2, 3, 4, or more natural amino acids and/or non-natural amino acids are connected by an amide bond and/or an ester bond. The peptide chain is preferably a peptide chain comprising 1 to 4 amino acid residues, and more preferably a peptide chain consisting of 1 to 4 amino acid residues. 
     “Optionally substituted” herein means that a group may be substituted with any substituent. 
     “Optionally protected” herein means that a group may be protected with any protecting group. 
     “One or more” herein means one or two or more. When “one or more” is used in a context relating to the substituent of a group, the phrase means a number encompassing one to the maximum number of substituents permitted by that group. Specific examples of “one or more” include 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and/or a greater number. 
     The compound of the present invention can be a salt thereof, and preferably a chemically or pharmaceutically acceptable salt thereof. Also, the compound of the present invention or a salt thereof can be a solvate thereof, and preferably a chemically or pharmaceutically acceptable solvate thereof. Examples of salts of the compound of the present invention include hydrochloride; hydrobromide; hydroiodide; phosphate; phosphonate; sulfate; sulfonates such as methanesulfonate and p-toluenesulfonate; carboxylates such as acetate, citrate, malate, tartrate, succinate, and salicylate; alkali metal salts such as a sodium salt and a potassium salt; alkaline earth metal salts such as a magnesium salt and a calcium salt; and ammonium salts such as an ammonium salt, an alkylammonium salt, a dialkylammonium salt, a trialkylammonium salt, and a tetraalkylammonium salt. These salts are produced by, for example, bringing the compound into contact with an acid or a base usable in the production of pharmaceutical products. In the present invention, a solvate of a compound refers to a phenomenon in which solute molecules strongly attract solvent molecules in a solution and form one molecular group, and is called a hydrate when the solvent is water. The solvate of the compound of the present invention is preferably a hydrate, and specific examples of such hydrates include mono- to deca-hydrates, preferably mono- to penta-hydrates, and more preferably mono- to tri-hydrates. The solvate of the compound of the present invention includes not only a solvate formed of a single solvent such as water, alcohol (e.g., methanol, ethanol, 1-propanol, or 2-propanol), or dimethylformamide, but also a solvate formed of a plurality of solvents. 
     The term “amino acid” as used herein includes natural and unnatural amino acids. The term “natural amino acid” as used herein refers to Gly, Ala, Ser, Thr, Val, Leu, Ile, Phe, Tyr, Trp, His, Glu, Asp, Gln, Asn, Cys, Met, Lys, Arg, or Pro. Examples of the unnatural amino acid include, but are not particularly limited to, β-amino acids, γ-amino acids, D-amino acids, N-substituted amino acids, α, α-disubstituted amino acids, amino acids having side chains that are different from those of natural amino acids, and hydroxycarboxylic acids. Amino acids herein may have any conformation. There is no particular limitation on the selection of amino acid side chain, but in addition to a hydrogen atom, it can be freely selected from, for example, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, an aralkyl group, and a cycloalkyl group. One or two non-adjacent methylene groups in such a group are optionally substituted with an oxygen atom, a carbonyl group (—CO—), or a sulfonyl group (—SO 2 —). Each group may have a substituent, and there are no limitations on the substituent. For example, one or more substituents may be freely and independently selected from any substituents including a halogen atom, an O atom, an S atom, an N atom, a B atom, an Si atom, or a P atom. Examples include an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, aralkyl group, and cycloalkyl group. In a non-limiting embodiment, amino acids herein may be compounds having a carboxy group and an amino group in the same molecule (even in this case, imino acids such as proline and hydroxyproline are also included in amino acids). 
     The main chain amino group of an amino acid may be unsubstituted (an NH 2  group) or substituted (i.e., an —NHR group, where R represents alkyl, alkenyl, alkynyl, aryl, heteroaryl, aralkyl, or cycloalkyl which may have a substituent, one or two non-adjacent methylene groups in such a group may be substituted with an oxygen atom, a carbonyl group (—CO—), or a sulfonyl group (—SO 2 —), and the carbon chain bonded to the N atom and the carbon atom at the position a may form a ring, as in proline). The R substituent is selected as the substituent in the aforementioned amino acid side chain is selected. When the main chain amino group is substituted, the R is included in the “amino acid side chain” as used herein. Such amino acids in which the main chain amino group is substituted are herein called “N-substituted amino acids.” Preferred examples of the “N-substituted amino acids” as used herein include, but are not limited to, N-alkylamino acids, N—C 1 -C 6  alkylamino acids, N—C 1 -C 4  alkylamino acids, and N-methylamino acids. 
     “Amino acids” as used herein which constitute a peptide compound include all isotopes corresponding to each amino acid. The isotope of the “amino acid” refers to one having at least one atom replaced with an atom of the same atomic number (number of protons) and different mass number (total number of protons and neutrons). Examples of isotopes contained in the “amino acid” constituting the peptide compounds of the present invention include a hydrogen atom, a carbon atom, a nitrogen atom, an oxygen atom, a phosphorus atom, a sulfur atom, a fluorine atom, and a chlorine atom, which respectively include  2 H and  3 H;  13 C and  14 C;  15 N;  17 O and  18 O;  31 P and  32 P;  35 S;  18 F; and  36 Cl. 
     Substituents containing a halogen atom as used herein include include a halogen-substituted alkyl group, cycloalkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, or aralkyl group. More specific examples include fluoroalkyl, difluoroalkyl, and trifluoroalkyl. 
     Substituents containing an O atom include groups such as hydroxy (—OH), oxy (—OR), carbonyl (—C═O—R), carboxy (—CO 2 H), oxycarbonyl (—C═O—OR), carbonyloxy (—O—C═O—R), thiocarbonyl (—C═O—SR), carbonylthio (—S—C═O—R), aminocarbonyl (—C═O—NHR), carbonylamino (—NH—C═O—R), oxycarbonylamino (—NH—C═O—OR), sulfonylamino (—NH—SO 2 —R), aminosulfonyl (—SO 2 —NHR), sulfamoylamino (—NH—SO 2 —NHR), thiocarboxyl (—C═O—SH), and carboxylcarbonyl (—C═O—CO 2 H). 
     Examples of oxy (—OR) include alkoxy, cycloalkoxy, alkenyloxy, alkynyloxy, aryloxy, heteroaryloxy, and aralkyloxy. The alkoxy is preferably C1-C4 alkoxy and C1-C2 alkoxy, and particularly preferably methoxy or ethoxy. 
     Examples of carbonyl (—C═O—R) include formyl (—C═O—H), alkylcarbonyl, cycloalkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl, arylcarbonyl, heteroarylcarbonyl, and aralkylcarbonyl. 
     Examples of oxycarbonyl (—C═O—OR) include alkyloxycarbonyl, cycloalkyloxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, and aralkyloxycarbonyl. 
     Examples of carbonyloxy (—O—C═O—R) include alkylcarbonyloxy, cycloalkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, arylcarbonyloxy, heteroarylcarbonyloxy, and aralkylcarbonyloxy. 
     Examples of thiocarbonyl (—C═O—SR) include alkylthiocarbonyl, cycloalkylthiocarbonyl, alkenylthiocarbonyl, alkynylthiocarbonyl, arylthiocarbonyl, heteroarylthiocarbonyl, and aralkylthiocarbonyl. 
     Examples of carbonylthio (—S—C═O—R) include alkylcarbonylthio, cycloalkylcarbonylthio, alkenylcarbonylthio, alkynylcarbonylthio, arylcarbonylthio, heteroarylcarbonylthio, and aralkylcarbonylthio. 
     Examples of aminocarbonyl (—C═O—NHR) include alkylaminocarbonyl (examples of which include C1-C6 or C1-C4 alkylaminocarbonyl, in particular, ethylaminocarbonyl and methylaminocarbonyl), cycloalkylaminocarbonyl, alkenylaminocarbonyl, alkynylaminocarbonyl, arylaminocarbonyl, heteroarylaminocarbonyl, and aralkylaminocarbonyl. Additional examples include compounds in which the H atom bonded to the N atom in —C═O—NHR is further replaced with alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl. 
     Examples of carbonylamino (—NH—C═O—R) include alkylcarbonylamino, cycloalkylcarbonylamino, alkenylcarbonylamino, alkynylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, and aralkylcarbonylamino. Additional examples include compounds in which the H atom bonded to the N atom in —NH—C═O—R is further replaced with alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl. 
     Examples of oxycarbonylamino (—NH—C═O—OR) include alkoxycarbonylamino, cycloalkoxycarbonylamino, alkenyloxycarbonylamino, alkynyloxycarbonylamino, aryloxycarbonylamino, heteroaryloxycarbonylamino, and aralkyloxycarbonylamino. Additional examples include compounds in which the H atom bonded to the N atom in —NH—C═O—OR is further replaced with alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl. 
     Examples of sulfonylamino (—NH—SO 2 —R) include alkylsulfonylamino, cycloalkylsulfonylamino, alkenylsulfonylamino, alkynylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, and aralkylsulfonylamino. Additional examples include compounds in which the H atom attached to the N atom in —NH—SO 2 —R is further replaced with alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl. 
     Examples of aminosulfonyl (—SO 2 —NHR) include alkylaminosulfonyl, cycloalkylaminosulfonyl, alkenylaminosulfonyl, alkynylaminosulfonyl, arylaminosulfonyl, heteroarylaminosulfonyl, and aralkylaminosulfonyl. Additional examples include compounds in which the H atom attached to the N atom in —SO 2 —NHR is further replaced with alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl. 
     Examples of sulfamoylamino (—NH—SO 2 —NHR) include alkylsulfamoylamino, cycloalkylsulfamoylamino, alkenylsulfamoylamino, alkynylsulfamoylamino, arylsulfamoylamino, heteroarylsulfamoylamino, and aralkylsulfamoylamino. The two H atoms bonded to the N atoms in —NH—SO 2 —NHR may be further replaced with substituents independently selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, and aralkyl, and these two substituents may form a ring. 
     Substituents containing an S atom include groups such as thiol (—SH), thio (—S—R), sulfinyl (—S═O—R), sulfonyl (—SO 2 —R), and sulfo (—SO 3 H). 
     Examples of thio (—S—R) include alkylthio, cycloalkylthio, alkenylthio, alkynylthio, arylthio, heteroarylthio, and aralkylthio. 
     Examples of sulfonyl (—SO 2 —R) include alkylsulfonyl, cycloalkylsulfonyl, alkenylsulfonyl, alkynylsulfonyl, arylsulfonyl, heteroarylsulfonyl, and aralkylsulfonyl. 
     Substituents containing an N atom include groups such as azido (—N 3 , also called “azido group”), cyano (—CN), primary amino (—NH 2 ), secondary amino (—NH—R; also called monosubstituted amino), tertiary amino (—NR(R′); also called disubstituted amino), amidino (—C(═NH)—NH 2 ), substituted amidino (—C(═NR)—NR′ R″), guanidino (—NH—C(═NH)—NH 2 ), substituted guanidino (—NR—C(═NR′″)—NR′R″), aminocarbonylamino (—NR—CO—NR′R″), pyridyl, piperidino, morpholino, and azetidinyl. 
     Examples of secondary amino (—NH—R; monosubstituted amino) include alkylamino, cycloalkylamino, alkenylamino, alkynylamino, arylamino, heteroarylamino, and aralkylamino. 
     Examples of tertiary amino (—NR(R′); disubstituted amino) include amino groups having any two substituents each independently selected from alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, and aralkyl, such as alkyl(aralkyl)amino, where any two such substituents may form a ring. Specific examples include dialkylamino, in particular, C1-C6 dialkylamino, C1-C4 dialkylamino, dimethylamino, and diethylamino. The term “C p -C q  dialkylamino group” as used herein refers to an amino group substituted with two C p -C q  alkyl groups, where the two C p -C q  alkyl groups may be the same or different. 
     Examples of substituted amidino (—C(═NR)—NR′ R″) include groups in which three substituents R, R′, and R′″ on the N atom are each independently selected from alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, and aralkyl, such as alkyl(aralkyl)(aryl)amidino. 
     Examples of substituted guanidino (—NR—C(═NR′″)—NR′R″) include groups in which R, R′, R″, and R′″ are each independently selected from alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, and aralkyl, or groups in which these substituents form a ring. 
     Examples of aminocarbonylamino (—NR—CO—NR′ R″) include groups in which R, R′, and R″ are each independently selected from a hydrogen atom, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, and aralkyl, or groups in which these substituents form a ring. 
     Herein, an “amino acid residue” constituting the peptide compound may be simply referred to as an “amino acid”. 
     In an embodiment, the present invention relates to a cyclic peptide compound represented by formula (1) below or a salt thereof, or a solvate thereof. 
     
       
         
         
             
             
         
       
     
     In formula (1), the ring is composed of 11 amino acid residues. Herein, the amino acid residue having P 1 , Q 1 , R 1 , and L 1  in the formula may be referred to as core 1, the amino acid residue having P 2 , Q 2 , and R 2  as core 2, the amino acid residue having P 3 , Q 3 , and R 3  as core 3, the amino acid residue having P 4 , Q 4 , and R 4  as core 4, the amino acid residue having P 5 , Q 5 , and R 5  as core 5, the amino acid residue having P 6 , Q 6 , and R 6  as core 6, the amino acid residue having P 7 , Q 7 , and R 7  as core 7, the amino acid residue having P 8 , Q 8 , and R 8  as core 8, the amino acid residue having P 9 , Q 9 , and R 9  as core 9, the amino acid residue having P 10 , Q 10 , and R 10  as core 10, and the amino acid residue having P 1 , Q 11 , R 11 , and L 11  as core 11. 
     In an embodiment, in formula (1), L 1  is a single bond or is —CHM 1 -, —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m —, or —(CH 2 ) n S(O) 2 (CH 2 ) m —, and L 11  is a single bond or is —CHM 11 -, —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m —, or —(CH 2 ) n S(O) 2 (CH 2 ) m —, wherein one of L 1  and L 11  is a single bond. That is, when L 1  is a single bond, L 11  is —CHM 11 -, —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m —, or —(CH 2 ) n S(O) 2 (CH 2 ) m —, and when L 11  is a single bond, L 1  is —CHM 1 -, —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m —, or —(CH 2 ) n S(O) 2 (CH 2 ) m —. M 1  is hydrogen except when R 1  and M 1  form a 3- to 8-membered alicyclic ring, and M 11  is hydrogen except when R 11  and M 11  form a 3- to 8-membered alicyclic ring. 
     When L 1  or L 11  is —(CH 2 ) n S(CH 2 ) m —, specific examples of —(CH 2 ) n S(CH 2 ) m — include —CH 2 SCH 2 —, —CH 2 CH 2 SCH 2 —, —CH 2 SCH 2 CH 2 —, and —CH 2 CH 2 SCH 2 CH 2 —. 
     When L 1  or L 11  is —(CH 2 ) n S(O)(CH 2 ) m —, specific examples of —(CH 2 ) n S(O)(CH 2 ) m -include —CH 2 S(O)CH 2 —, —CH 2 CH 2 S(O)CH 2 —, —CH 2 S(O)CH 2 CH 2 —, and —CH 2 CH 2 S(O)CH 2 CH 2 —. 
     When L 1  or L 11  is —(CH 2 ) n S(O) 2 (CH 2 ) m —, specific examples of —(CH 2 ) n S(O) 2 (CH 2 ) m -include —CH 2 S(O) 2 CH 2 —, —CH 2 CH 2 S(O) 2 CH 2 —, —CH 2 S(O) 2 CH 2 CH 2 —, and —CH 2 CH 2 S(O) 2 CH 2 CH 2 —. 
     In an embodiment, in formula (1), R 1  is hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, or C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), and C 1 -C 6  alkylsulfonyl. 
     When core 1 is α-amino acid (i.e., L 1  is a single bond), R 1  is preferably C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkylsulfonylC 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with one or more halogens, aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), or hydroxy), C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, or C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl. 
     In this embodiment, R 1  is more preferably C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 1 -C 4  hydroxyalkyl, methylsulfonylC 1 -C 2  alkyl, C 2 -C 3  alkynyl; C 1 -C 6  alkoxyC 1 -C 2  alkyl optionally substituted with one or more fluorines, mono-C 1 -C 4  alkylaminocarbonyl, or hydroxy; C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylC 1 -C 2  alkyl, or C 3 -C 6  cycloalkoxyC 1 -C 2  alkyl. 
     In this embodiment, specific examples of R 1  include methyl, ethyl, i-propyl, n-propyl, 2-methylpropyl, 1-methylpropyl, n-butyl, n-hexyl, 3-methylbutyl, 2-methylbutyl, n-pentyl, but-3-yn-1-yl, propargyl, (2-hydroxy-2-methyl-propyloxy)methyl, (2-(t-butylamino)-2-oxoethoxy)methyl, 3,3-difluorobutyl, n-propoxymethyl, hydroxymethyl, 2,2,2-trifluoroethyl, 5,5-difluoropentyl, methoxymethyl, 3-methylbutoxymethyl, 1-hydroxyethyl, cyclobutoxymethyl, (2,2,2-trifluoroethoxy)methyl, 1-methoxyethyl, 2-methoxyethyl, 2-methylsulfonylethyl, cyclohexyl, cyclobutyl, cyclopropyl, cyclopentyl, cyclohexylmethyl, cyclopentylmethyl, cyclobutylmethyl, cyclopropylmethyl, and cyclopropoxymethyl. 
     When core 1 is β-amino acid (i.e., L 1  is —CHM 1 -), R 1  is preferably hydrogen. 
     In an embodiment, in formula (1), R 1  and P 1 , together with the carbon atom to which R 1  is attached and the nitrogen atom to which P 1  is attached, can form a 4- to 7-membered saturated heterocyclic ring. 
     When R 1  and P 1  form a 4- to 7-membered saturated heterocyclic ring, the 4- to 7-membered saturated heterocyclic ring is preferably an azetidine ring, a pyrrolidine ring, a piperidine ring, a piperazine ring, or a morpholine ring. 
     In an embodiment, in formula (1), R 1  and Q 1 , together with the carbon atom to which they are attached, can form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring. 
     When R 1  and Q 1  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, the 3- to 8-membered alicyclic ring is preferably a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, or a cyclohexane ring, and the 4- to 7-membered saturated heterocyclic ring is preferably a tetrahydrofuran ring or a tetrahydropyran ring. 
     In an embodiment, in formula (1), when core 1 is β-amino acid, R 1  and M 1 , together with the carbon atom to which R 1  is attached and the carbon atom to which M 1  is attached, can form a 3- to 8-membered alicyclic ring. 
     When R 1  and M 1  form a 3- to 8-membered alicyclic ring, the 3- to 8-membered alicyclic ring is preferably a cyclopentane ring or a cyclohexane ring. 
     In an embodiment, in formula (1), when core 1 is β-amino acid, M 1  is hydrogen except when R 1  and M 1  form a 3- to 8-membered alicyclic ring. 
     In an embodiment, in formula (1), except when R 1  and P 1  form a 4- to 7-membered saturated heterocyclic ring, P 1  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). 
     P 1  is preferably hydrogen or C 1 -C 6  alkyl. Specific examples of such P 1  include hydrogen, methyl, ethyl, and n-propyl. 
     In an embodiment, except when R 1  and Q 1  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 1  is hydrogen or C 1 -C 6  alkyl, and preferably hydrogen. 
     When core 1 is α-amino acid, specific examples of core 1 include MeAla, Ala, Pic(2), MeLeu, MeCha, MeVal, EtAla, nPrAla, MeSer(tBuOH), MeSer(NtBu-Aca), MeAla(cPent), MeAla(cBu), MeAla(cPr), MeChg, MeGly(cPent), MeGly(cBu), MeGly(cPr), MeAbu, MeNva, MeNle, Val, Leu, MeAOC(2), MeNva(5-F2), MeHle, MeIle, MeSer(nPr), MeSer(cPr), MeSer, MeAbu(4-F3), MeHnl, MeHnl(7-F2), MePRA, MeSer(Me), MeSer(iPen), MeThr, MeSer(cBu), MeSer(Tfe), MeThr(Me), MeHse(Me), MeMet(02), MeAhxy(2), and EtLeu. 
     When core 1 is β-amino acid, specific examples of core 1 include bAla and bMeAla. 
     In an embodiment, in formula (1), R 2  is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, or C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, cyano, and C 1 -C 6  alkylsulfonyl. 
     R 2  is preferably C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkylsulfonylC 1 -C 6  alkyl, C 1 -C 6  cyanoalkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, or C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl. 
     R 2  is more preferably C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 1 -C 4  hydroxyalkyl, methylsulfonylC 1 -C 2  alkyl, C 2 -C 6  alkenyl, C 2 -C 3  alkynyl, C 1 -C 6  alkoxyC 1 -C 2  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylC 1 -C 2  alkyl, or C 3 -C 6  cycloalkoxyC 1 -C 2  alkyl. 
     Specific examples of R 2  include methyl, ethyl, n-propyl, i-propyl, n-butyl, 2-methylpropyl, 1-methylpropyl, n-pentyl, 3-methylbutyl, 2-methylbutyl, pentan-3-yl, n-propoxymethyl, cyclopropoxymethyl, hydroxymethyl, 2,2,2-trifluoroethyl, 5,5-difluoropentyl, methoxymethyl, 3-methyl-butoxy-methyl, 2-hydroxyethyl, cyclobutoxymethyl, (2,2,2-trifluoroethoxy)methyl, cyanomethyl, 1-methoxyethyl, 2-methoxyethyl, 2-methylsulfonylethyl, allyl, 3-methylbut-2-en-1-yl, propargyl, cyclohexyl, cyclopentyl, cyclobutyl, cyclopropyl, cyclohexylmethyl, cyclopentylmethyl, cyclobutylmethyl, and cyclopropylmethyl. 
     In an embodiment, in formula (1), R 2  and P 2 , together with the carbon atom to which R 2  is attached and the nitrogen atom to which P 2  is attached, can form a 4- to 7-membered saturated heterocyclic ring. 
     When R 2  and P 2  form a 4- to 7-membered saturated heterocyclic ring, the 4- to 7-membered saturated heterocyclic ring is preferably an azetidine ring, a pyrrolidine ring, a piperidine ring, a piperazine ring, or a morpholine ring. 
     In an embodiment, in formula (1), R 2  and Q 2 , together with the carbon atom to which they are attached, can form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring. 
     When R 2  and Q 2  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, the 3- to 8-membered alicyclic ring is preferably a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, or a cyclohexane ring, and the 4- to 7-membered saturated heterocyclic ring is preferably a tetrahydrofuran ring or a tetrahydropyran ring. 
     In an embodiment, in formula (1), except when R 2  and P 2  form a 4- to 7-membered saturated heterocyclic ring, P 2  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). P 2  is preferably hydrogen. 
     In an embodiment, except when R 2  and Q 2  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 2  is hydrogen or C 1 -C 6  alkyl, and preferably hydrogen. 
     Specific examples of core 2 include Ala, Val, Leu, Ile, Nle, PRA, Chg, Cha, Ala(cPent), Ala(cBu), Ala(cPr), Gly(cPent), Gly(cBu), Gly(cPr), Hle, Ser(nPr), Ser(cPr), Ser, Abu(4-F3), Ahp(2), Abu, Nva, Hnl(7-F2), Ser(Me), Ser(iPen), Thr, Algly, Pregly, Ser(cBu), Ser(Tfe), Ala(CN), Thr(Me), Hse(Me), Met(O2), and Nva(3-Et). 
     In an embodiment, in formula (1), R 3  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, or C 7 -C 14  aralkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of hydroxy and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). 
     R 3  is preferably hydrogen, C 1 -C 6  alkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino) or hydroxy), aminocarbonylC 1 -C 6  alkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, or C 7 -C 14  aralkyl. 
     R 3  is more preferably hydrogen, C 1 -C 6  alkyl, C 1 -C 4  hydroxyalkyl, C 1 -C 6  alkoxyC 1 -C 2  alkyl optionally substituted with mono-C 1 -C 4  alkylaminocarbonyl or hydroxy, mono-C 1 -C 4  alkylaminocarbonylC 1 -C 2  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylC 1 -C 2  alkyl, benzyl, or phenethyl. 
     Specific examples of R 3  include hydrogen, methyl, ethyl, n-propyl, i-propyl, n-butyl, 2-methylpropyl, 3-methylbutyl, (2-hydroxy-2-methyl-propyloxy)methyl, (2-(tert-butylamino)-2-oxoethoxy)methyl, n-propoxymethyl, cyclopropoxymethyl, 3-methylbutoxymethyl, 1-hydroxyethyl, 3-methylamino-3-oxo-propyl, cyclohexyl, cyclobutyl, cyclopropyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, benzyl, and phenethyl. 
     In an embodiment, in formula (1), R 3  and P 3 , together with the carbon atom to which R 3  is attached and the nitrogen atom to which P 3  is attached, can form a 4- to 7-membered saturated heterocyclic ring. 
     When R 3  and P 3  form a 4- to 7-membered saturated heterocyclic ring, the 4- to 7-membered saturated heterocyclic ring is preferably an azetidine ring, a pyrrolidine ring, a piperidine ring, a piperazine ring, or a morpholine ring. 
     In an embodiment, in formula (1), R 3  and Q 3 , together with the carbon atom to which they are attached, can form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring. 
     When R 3  and Q 3  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, the 3- to 8-membered alicyclic ring is preferably a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, or a cyclohexane ring, and the 4- to 7-membered saturated heterocyclic ring is preferably a tetrahydrofuran ring or a tetrahydropyran ring. 
     In an embodiment, in formula (1), except when R 3  and P 3  form a 4- to 7-membered saturated heterocyclic ring, P 3  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, or C 3 -C 8  cycloalkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). 
     P 3  is preferably hydrogen, C 1 -C 6  alkyl, C 1 -C 6  aminoalkyl (wherein the amino is —NH 2 , protected amino, mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogens), or C 3 -C 8  cycloalkyl. 
     P 3  is more preferably hydrogen, C 1 -C 6  alkyl, C 1 -C 4  alkoxyC 1 -C 2  alkyl, 4- to 8-membered cyclic aminoC 1 -C 2  alkyl optionally substituted with one or more halogens, or C 3 -C 6  cycloalkyl. Specific examples of such P 3  include hydrogen, methyl, ethyl, n-propyl, i-propyl, cyclopropyl, n-butyl, i-butyl, 2-ethoxyethyl, and 2-(4,4-difluoro-1-piperidyl)ethyl. 
     In an embodiment, except when R 3  and Q 3  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 3  is hydrogen or C 1 -C 6  alkyl, and preferably hydrogen. 
     Specific examples of core 3 include MeAla, Ala, Pic(2), MeLeu, MeCha, MeVal, EtAla, MeSer(tBuOH), MeSer(NtBu-Aca), MeAla(cPent), MeAla(cBu), MeAla(cPr), MeChg, MeGly(cBu), MeGly(cPr), MeAbu, MeNva, MeNle, MeHle, MeSer(nPr), MeSer(cPr), MeSer(iPen), MeThr, Abu, MeGly, EtGly, Gly, nBuGly, iPrGly, cPrGly, nPrGly, iBuGly, (EtOEt)NGly, 2-(pip-4-F2)-EtGly, Pro, Aze(2), MeGln(Me), MePhe, and MeHph. 
     In one embodiment, in formula (1), R 4  is hydrogen or C 1 -C 6  alkyl, and preferably hydrogen or C 1 -C 4  alkyl. Specific examples of R 4  include hydrogen and methyl. 
     In an embodiment, in formula (1), R 4  and P 4 , together with the carbon atom to which R 4  is attached and the nitrogen atom to which P 4  is attached, can form a 4- to 7-membered saturated heterocyclic ring (preferably, 4- or 5-membered saturated heterocyclic ring). 
     When R 4  and P 4  form a 4- to 7-membered saturated heterocyclic ring, the 4- to 7-membered saturated heterocyclic ring is preferably an azetidine ring, a pyrrolidine ring, a piperidine ring, a piperazine ring, or a morpholine ring. 
     In an embodiment, in formula (1), R 4  and Q 4 , together with the carbon atom to which they are attached, can form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring. 
     When R 4  and Q 4  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, the 3- to 8-membered alicyclic ring is preferably a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, or a cyclohexane ring, and the 4- to 7-membered saturated heterocyclic ring is preferably a tetrahydrofuran ring or a tetrahydropyran ring. 
     In an embodiment, in formula (1), except when R 4  and P 4  form a 4- to 7-membered saturated heterocyclic ring, P 4  is hydrogen, C 1 -C 6  alkyl, or C 1 -C 6  alkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). 
     P 4  is preferably C 1 -C 6  alkyl or C 1 -C 6  alkoxyC 1 -C 6  alkyl. 
     P 4  is more preferably hydrogen, C 1 -C 6  alkyl, or C 1 -C 4  alkoxyC 1 -C 2  alkyl. Specific examples of P 4  include methyl, ethyl, n-propyl, n-butyl, i-propyl, i-pentyl, and 2-ethoxyethyl. 
     In an embodiment, except when R 4  and Q 4  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 4  is hydrogen or C 1 -C 6  alkyl, and preferably hydrogen. 
     Specific examples of core 4 include MeAla, Pic(2), MeGly, EtGly, nBuGly, nPrGly, (EtOEt)NGly, Pro, Aze(2), and iPenGly. 
     In an embodiment, in formula (1), R 5  is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl, C 6 -C 10  aryloxyC 1 -C 6  alkyl, C 7 -C 14  aralkoxyC 1 -C 6  alkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, cyano, and C 1 -C 6  alkylsulfonyl. 
     R 5  is preferably C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 2 -C 6  alkenyl, C 1 -C 6  alkylsulfonylC 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl (wherein the C 7 -C 14  aralkyl is optionally substituted with one or more halogens, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, or cyano), C 6 -C 10  aryloxyC 1 -C 6  alkyl optionally substituted with one or more halogens, C 7 -C 14  aralkoxyC 1 -C 6  alkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl. 
     R 5  is more preferably C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 1 -C 4  hydroxyalkyl, C 2 -C 3  alkenyl, C 2 -C 3  alkynyl, methylalkylsulfonylC 1 -C 2  alkyl, C 1 -C 6  alkoxyC 1 -C 2  alkyl optionally substituted with one or more fluorines, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylC 1 -C 2  alkyl, C 3 -C 6  cycloalkoxyC 1 -C 2  alkyl, benzyl or phenethyl optionally substituted with one or more halogens, methyl, methoxy, trifluoromethyl, trifluoromethoxy, or cyano, phenoxyC 1 -C 2  alkyl optionally substituted with one or more halogens, benzyloxyC 1 -C 2  alkyl, and 5- to 6-membered heteroarylC 1 -C 2  alkyl. 
     Specific examples of R 5  include methyl, ethyl, n-propyl, i-propyl, n-butyl, 2-methylpropyl, 1-methylpropyl, 2-methylbutyl, 3-methylbutyl, n-pentyl, propargyl, 3,3-difluorobutyl, n-propoxymethyl, cyclopropoxymethyl, hydroxymethyl, 2,2,2-trifluoroethyl, 5,5-difluorobutyl, methoxymethyl, 3-methylbutoxymethyl, 1-hydroxyethyl, cyclobutoxymethyl, (2,2,2-trifluoroethoxy)methyl, 1-methoxyethyl, 2-methoxyethyl, 2-methylsulfonylethyl, (2-chlorophenoxy)methyl, allyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, cyclopentylmethyl, cyclohexylmethyl, cyclobutylmethyl, cyclopropylmethyl, pyridin-3-ylmethyl, phenethyl, 4-chlorobenzyl, 2-cyanobenzyl, 3-cyanobenzyl, 4-ethynylbenzyl, 2-fluorobenzyl, 2-chlorobenzyl, 3-chlorobenzyl, 3-bromobenzyl, 4-bromobenzyl, 2-methylbenzyl, 3-methylbenzyl, 4-methylbenzyl, 2-(trifluoromethyl)benzyl, 3-(trifluoromethyl)benzyl, 4-(trifluoromethyl)benzyl, 4-methoxybenzyl, 2-(trifluoromethoxy)benzyl, 3-(trifluoromethoxy)benzyl, 4-(trifluoromethoxy)benzyl, 3,4-difluorobenzyl, 4-iodobenzyl, benzyl, 3-fluorobenzyl, and 4-fluorobenzyl. 
     In an embodiment, in formula (1), R 5  together with R 8  can form C 4 -C 8  alkylene. C 4 -C 8  alkylene is preferably —(CH 2 ) 8 —. 
     In an embodiment, in formula (1), R 5  and P 5 , together with the carbon atom to which R 5  is attached and the nitrogen atom to which P 5  is attached, can form a 4- to 7-membered saturated heterocyclic ring. 
     When R 5  and P 5  form a 4- to 7-membered saturated heterocyclic ring, the 4- to 7-membered saturated heterocyclic ring is preferably an azetidine ring, a pyrrolidine ring, a piperidine ring, a piperazine ring, or a morpholine ring. 
     In an embodiment, in formula (1), R 5  and Q 5 , together with the carbon atom to which they are attached, can form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring. 
     When R 5  and Q 5  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, the 3- to 8-membered alicyclic ring is preferably a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, or a cyclohexane ring, and the 4- to 7-membered saturated heterocyclic ring is preferably a tetrahydrofuran ring or a tetrahydropyran ring. 
     In an embodiment, in formula (1), except when R 5  and P 5  form a 4- to 7-membered saturated heterocyclic ring, P 5  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). 
     P 5  is preferably hydrogen or C 1 -C 2  alkyl, and specific examples include hydrogen, methyl, and ethyl. 
     In an embodiment, except when R 5  and Q 5  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 5  is hydrogen or C 1 -C 6  alkyl, and preferably hydrogen. 
     Specific examples of core 5 include MeAla, MeLeu, MeCha, MeVal, MeAla(cPent), MeAla(cBu), MeAla(cPr), MeChg, MeGly(cPent), MeGly(cBu), MeGly(cPr), MeAbu, MeNva, MeNle, MeNva(5-F2), MeHle, MeIle, MeSer(nPr), MeSer(cPr), MeSer, MeAbu(4-F3), MeHnl, MeHnl(7-F2), MePRA, MeSer(Me), MeSer(iPen), MeThr, MeSer(cBu), MeSer(Tfe), MeThr(Me), MeHse(Me), MeMet(02), MePhe, MeHph, MePhe(4-Cl), MeThr(Bn), EtPhe(4-Cl), MePhe(2-CN), MePhe(3-CN), MePhe(4-CN), MePhe(2-F), MePhe(3-F), MePhe(4-F), MePhe(2-Cl), MePhe(3-Cl), MePhe(3-Br), MePhe(4-Br), MePhe(2-Me), MePhe(3-Me), MePhe(4-Me), MePhe(2-CF3), MePhe(3-CF3), MePhe(4-CF3), MeTyr(Me), MePhe(2-OCF3), MePhe(3-OCF3), MePhe(4-OCF3), MeSer(Ph-2-Cl), MeAlgly, MePhe(34-F2), MeAla(3-Pyr), MePhe(4-I), EtCha, EtPhe(4-Me), EtPhe(4-CF3), and Phe(4-Me). 
     In an embodiment, in formula (1), R 6  is hydrogen or C 1 -C 6  alkyl, and preferably hydrogen or C 1 -C 3  alkyl. Specific examples of R 6  include hydrogen and methyl. 
     In an embodiment, in formula (1), R 6  and P 6 , together with the carbon atom to which R 6  is attached and the nitrogen atom to which P 6  is attached, can form a 4- to 7-membered saturated heterocyclic ring. 
     When R 6  and P 6  form a 4- to 7-membered saturated heterocyclic ring, the 4- to 7-membered saturated heterocyclic ring is preferably an azetidine ring, a pyrrolidine ring, a piperidine ring, a piperazine ring, or a morpholine ring. 
     In an embodiment, in formula (1), R 6  and Q 6 , together with the carbon atom to which they are attached, can form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring. 
     When R 6  and Q 6  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, the 3- to 8-membered alicyclic ring is preferably a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, or a cyclohexane ring, and the 4- to 7-membered saturated heterocyclic ring is preferably a tetrahydrofuran ring or a tetrahydropyran ring. 
     In an embodiment, in formula (1), except when R 6  and P 6  form a 4- to 7-membered saturated heterocyclic ring, P 6  is C 1 -C 6  alkyl or C 3 -C 8  cycloalkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxyamino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). 
     P 6  is preferably C 1 -C 6  alkyl or C 3 -C 8  cycloalkyl, and more preferably C 1 -C 4  alkyl or C 3 -C 6  cycloalkyl. Specific examples of such P 6  include methyl, ethyl, and cyclopropyl. 
     In an embodiment, except when R 6  and Q 6  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 6  is hydrogen or C 1 -C 6  alkyl, and preferably hydrogen. 
     Specific examples of core 6 include MeAla, MeGly, EtGly, cPrGly, D-Pro, D-MeAla, and D-Pic(2). 
     In an embodiment, in formula (1), R 7  is C 6 -C 10  aryloxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl, C 7 -C 14  aralkoxyC 1 -C 6  alkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, cyano, C 1 -C 6  alkylsulfonyl, and SF 5 . 
     R 7  is preferably C 6 -C 10  aryloxyC 1 -C 6  alkyl (wherein the C 6 -C 10  aryloxyC 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen and C 1 -C 6  haloalkyl), C 7 -C 14  aralkyl (wherein the C 7 -C 14  aralkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 2 -C 6  alkynyl, cyano, C 1 -C 6  alkylsulfonyl, and SF 5 ), C 7 -C 14  aralkoxyC 1 -C 6  alkyl optionally substituted with one or more halogens, or 5- to 10-membered heteroarylC 1 -C 6  alkyl (wherein the 5- to 10-membered heteroarylC 1 -C 6  alkyl is optionally substituted with one or more halogens, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, or C 1 -C 6  alkoxy). 
     R 7  is preferably —(CH 2 ) x —O y —(CH 2 ) z1 —C 6 -C 10  aryl or —(CH 2 ) x —O y —(CH 2 ) z2 -5- to 10-membered heteroaryl optionally substituted with one to five groups independently selected from the group consisting of halogen, C 1 -C 4  alkyl (preferably methyl), C 2 -C 4  alkynyl (preferably ethynyl), C 1 -C 3  haloalkyl (preferably difluoromethyl, trifluoromethyl), C 1 -C 3  haloalkoxy (preferably difluoromethoxy, trifluoromethoxy), C 1 -C 4  alkoxy (preferably methoxy, ethoxy, isopropoxy, n-butoxy, t-butoxy), —CN, C 1 -C 3  alkylsulfonyl (preferably methylsulfonyl), and SF 5 , wherein x is 1, 2, or 3, y is 0 or 1, and z1 is 0, 1, 2, or 3, provided that the sum of x, y, and z1 or z2 is 1 to 4. Such —(CH 2 ) x —O y —(CH 2 ) z1 —C 6 -C 10  aryl or —(CH 2 ) x —O y —(CH 2 ) z2 -5- to 10-membered heteroaryl is preferably —CH 2 —C 6 -C 10  aryl or —(CH 2 ) 2 —C 6 -C 10  aryl, which is optionally substituted with the above-mentioned group(s). When —(CH 2 ) x —O y —(CH 2 ) z1 —C 6 -C 10  aryl has a substituent, the substituent is preferably on C 6 -C 10  aryl in the group, and when —(CH 2 ) x —O y —(CH 2 ) z2 -5- to 10-membered heteroaryl has a substituent, the substituent is preferably on 5- to 10-membered heteroaryl in the group. 
     Specific examples of R 7  include ((4-chlorobenzyl)oxy)methyl, 2-(4-chlorophenoxy)ethyl, 2-(3,4-dichlorophenoxy)ethyl, 2-(4-(trifluoromethylphenoxy))ethyl, (4-chlorophenoxy)methyl, ((3-chlorobenzyl)oxy)methyl, ((2-chlorobenzyl)oxy)methyl, 3-iodobenzyl, 3-chlorobenzyl, 3-methylbenzyl, 3-fluorobenzyl, 3,5-difluorobenzyl, 4-methylphenethyl, 4-(trifluoromethyl)phenethyl, 3-chloro-5-fluorobenzyl, 3-cyanobenzyl, 3-(trifluoromethoxy)benzyl, benzyl, 4-fluorophenethyl, 2-fluoro-4-(trifluoromethyl)phenethyl, 3-chlorophenethyl, 4-chlorophenethyl, 3-fluoro-4-(trifluoromethyl)phenethyl, 2,3,4,5,6-pentafluorophenethyl, 2,4,5-trifluorophenethyl, 2,5-difluorophenethyl, 2-fluoro-4-chlorophenethyl, 2,4-difluorophenethyl, 2-fluoro-6-chlorophenethyl, 2,4,6-trifluorophenethyl, 3-chloro-4-(trifluoromethyl)phenethyl, 3-trifluoromethylphenethyl, 4-(pentafluoro-k6-sulfanyl)phenethyl, 3,5-difluoro-4-(trifluoromethyl)phenethyl, 3-methoxybenzyl, 3,5-dichlorobenzyl, 3-chloro-4-fluorobenzyl, phenethyl, 3,4-dichlorophenethyl, 3-bromobenzyl, 4-fluorobenzyl, 2-fluoro-5-iodobenzyl, 2-chloro-5-iodobenzyl, 3-ethynylbenzyl, 3-fluorophenethyl, 3-phenylpropyl, 2-fluorobenzyl, 2-fluoro-3-iodobenzyl, 2-fluoro-3-bromobenzyl, 3-iodo-5-fluorobenzyl, 3-iodo-5-chlorobenzyl, 3-bromo-5-fluorobenzyl, 2-bromo-5-iodobenzyl, 2-methyl-5-iodobenzyl, 2-fluoro-5-methylbenzyl, 2-chloro-5-bromobenzyl, 2-methyl-5-bromobenzyl, 2,3-difluorobenzyl, 2,5-difluorobenzyl, 2,6-difluorobenzyl, 3-fluoro-4-(difluoromethoxy)phenethyl, 3-cyano-4-(trifluoromethyl)phenethyl, 3-methoxy-4-(trifluoromethyl)phenethyl, 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)ethyl, 3-chloro-4-(trifluoromethoxy)phenethyl, 3-fluoro-4-(trifluoromethoxy)phenethyl, 4-(methylsulfonyl)phenethyl, 3-fluoro-4-(difluoromethyl)phenethyl, 3,4,5-trichlorophenethyl, 3,4-dichloro-5-methoxyphenethyl, 3.4-dichloro-5-cyanophenethyl, 3,4-dichloro-5-isopropoxyphenethyl, 3,4-dichloro-5-(n-butoxy)phenethyl, 3,4-dichloro-5-(t-butoxy)phenethyl, 3-(4-(trifluoromethyl)phenyl)propyl, (5-chlorothiophen-2-yl)methyl, (5-bromothiophen-2-yl)methyl, (5-bromopyridin-3-yl)methyl,2-(6-(trifluoromethyl)pyridin-3-yl)ethyl, 2-(quinolin-6-yl)ethyl, 2-(1-methyl-1H-indol-6-yl)ethyl, 2-(1-methyl-1H-indol-5-yl)ethyl, 2-(6-methoxypyridin-3-yl)ethyl, 2-(benzofuran-5-yl)ethyl, 2-(6-(difluoromethyl)pyridin-3-yl)ethyl, 2-(5-(trifluoromethyl)pyridin-2-yl)ethyl, and 2-(quinolin-7-yl)ethyl. 
     In an embodiment, in formula (1), R 7  and P 7 , together with the carbon atom to which R 7  is attached and the nitrogen atom to which P 7  is attached, can form a 4- to 7-membered saturated heterocyclic ring. 
     When R 7  and P 7  form a 4- to 7-membered saturated heterocyclic ring, the 4- to 7-membered saturated heterocyclic ring is preferably an azetidine ring, a pyrrolidine ring, a piperidine ring, a piperazine ring, or a morpholine ring. 
     In an embodiment, in formula (1), R 7  and Q 7 , together with the carbon atom to which they are attached, can form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring. 
     When R 7  and Q 7  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, the 3- to 8-membered alicyclic ring is preferably a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, or a cyclohexane ring, and the 4- to 7-membered saturated heterocyclic ring is preferably a tetrahydrofuran ring or a tetrahydropyran ring. 
     In an embodiment, in formula (1), except when R 7  and P 7  form a 4- to 7-membered saturated heterocyclic ring, P 7  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). P 7  is preferably hydrogen. 
     In an embodiment, except when R 7  and Q 7  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 7  is hydrogen, C 1 -C 6  alkyl, or C 7 -C 14  aralkyl, and is preferably hydrogen. 
     Specific examples of core 7 include Phe(3-Cl), Phe(3-Me), Phe(3-F), Phe(35-F2), Hph(4-Me), Hph(4-CF3), Phe(3-Cl-5-F), Phe(3-I), Phe(3-CN), Phe(3-OCF3), Phe, Hph(4-F), Hph(4-CF3-2-F), Hph(3-Cl), Hph(4-Cl), Hph(4-CF3-3-F), Hph(F5), Hph(245-F3), Hph(2-F-5-Cl), Hph(2-F-4-Cl), Hph(24-F2), Hph(2-F-6-Cl), Hph(246-F3), Hph(4-CF3-3-Cl), Hph(3-CF3), Hph(4-SF5), Hph(4-CF3-35-F2), Phe(3-OMe), Phe(35-Cl2), Phe(3-Cl-4-F), Hph, Hph(34-Cl2), Phe(3-Br), Phe(4-F), Phe(2-F-5-I), Phe(2-Cl-5-I), Ala(2-Thie-5-Cl), Ala(2-Thie-5-Br), (Me)Phe(3-I), Phe(3-C#C), Hph(3-F), Phe3, Phe(2-F), Phe(2-F-3-I), Phe(2-F-3-Br), Phe(3-I-5-F), Phe(3-I-5-Cl), Ala(3-Pyr-5-Br), Phe(3-Br-5-F), Phe(2-Br-5-I), Phe(2-Me-5-I), Phe(2-F-5-Br), Phe(2-Cl-5-Br), Phe(2-Me-5-Br), Phe(23-F2), Phe(25-F2), Phe(26-F2), Hph(3-F-4-OCHF2), Hph(3-CN-4-CF3), Hph(3-OMe-4-CF3), Abu(3-Pyr-4-CF3), Abu(34-Cate(CF2)), Hph(3-Cl-4-OCF3), Hph(3-F-4-OCF3), Abu(6-Quino), Abu(1-Me-6-Indo), Abu(1-Me-5-Indo), Abu(3-Pyr-4-OMe), Abu(5-Bzfr), Abu(3-Pyr-4-CHF2), Abu(2-Pyr-4-CF3), Hph(4-SO2Me), Hph(3-F-4-CHF2), Abu(7-Quino), Hph(345-Cl3), Hph(34-Cl2-5-OMe), Hph(34-Cl2-5-CN), Hph(34-Cl2-5-OiPr), Hph(34-Cl2-5-OnBu), Hph(34-Cl2-5-OtBu), Phe3(4-CF3), Ser(Bn-4-Cl2), Hse(Ph-4-Cl), Hse(Ph-34-Cl2), Hse(Ph-4-CF3), Ser(Ph-4-Cl), Ser(Bn-3-Cl), and Ser(Bn-2-Cl). 
     In an embodiment, in formula (1), R 8  is hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 2 -C 6  alkenyloxycarbonylC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 6 -C 10  aryloxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl, C 7 -C 14  aralkoxyC 1 -C 6  alkyl, 5 to 10-membered heteroarylC 1 -C 6  alkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, carboxy, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, cyano, amino (wherein the amino is —NH 2 , protected amino, mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), 4- to 7-membered heterocycloalkylidene, protected 4- to 7-membered heterocycloalkylidene, 4- to 7-membered heterocyclyl, and protected 4- to 7-membered heterocyclyl. 
     R 8  is preferably hydrogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  carboxyalkyl, C 1 -C 6  aminoalkyl (wherein the amino is —NH 2 , protected amino, mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogen atoms), aminocarbonylC 1 -C 6  alkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogen atoms), optionally protected 4- to 7-membered heterocyclylC 1 -C 6  alkyl, optionally protected 4- to 7-membered heterocycloalkylideneC 1 -C 6  alkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino) or hydroxy), C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkenyloxycarbonylC 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 6 -C 10  aryloxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl (wherein the C 7 -C 14  aralkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, and cyano), 5- to 10-membered heteroarylC 1 -C 6  alkyl (wherein the 5- to 10-membered heteroarylalkyl is optionally substituted with one or more groups selected from the group consisting of C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, and cyano), or 5- to 10-membered heteroarylC 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with one or more halogen atoms. 
     R 8  is more preferably hydrogen, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 1 -C 4  hydroxyalkyl, C 1 -C 4  carboxyalkyl, protected aminoC 1 -C 4  alkyl, mono-C 1 -C 4  alkylaminocarbonylC 1 -C 2  alkyl, di-C 1 -C 4  alkylaminocarbonylC 1 -C 2  alkyl, 4- to 8-membered cyclic aminocarbonylC 1 -C 2  alkyl optionally substituted with one or more fluorine atoms, 4- to 8-membered cyclic aminoC 1 -C 2  alkyl optionally substituted with one or more fluorine atoms, optionally protected 4- to 7-membered heterocyclylC 1 -C 2  alkyl, optionally protected 4- to 7-membered heterocycloalkylideneC 1 -C 2  alkyl, mono-C 1 -C 4  alkylaminocarbonylmethyloxyC 1 -C 2  alkyl, C 1 -C 4  alkoxyC 1 -C 2  alkyl optionally substituted with hydroxy, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylC 1 -C 2  alkyl, C 2 -C 6  alkenyl, C 2 -C 3  alkynyl, C 2 -C 3  alkenyloxycarbonylC 1 -C 2  alkyl, phenoxyC 1 -C 2  alkyl; benzyl or phenethyl optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, methyl, difluoromethyl, trifluoromethyl, methoxy, trifluoromethoxy, hydroxy, and cyano; 5- to 6-membered heteroarylC 1 -C 2  alkyl optionally substituted with one or more groups selected from the group consisting of methyl, trifluoromethyl, methoxy, and cyano; or 5- to 6-membered heteroarylmethoxyC 1 -C 2  alkyl optionally substituted with one or more halogen atoms. 
     In an embodiment, R 8  is preferably —(CH 2 ) x —O y —(CH 2 ) z1 —C 6 -C 10  aryl or —(CH 2 ) x —O y —(CH 2 ) z2 -5- to 10-membered heteroaryl optionally substituted with one to five groups independently selected from the group consisting of halogen, C 1 -C 4  alkyl (preferably methyl), C 2 -C 4  alkynyl (preferably ethynyl), C 1 -C 3  haloalkyl (preferably difluoromethyl, trifluoromethyl), C 1 -C 3  haloalkoxy (preferably trifluoromethoxy), C 1 -C 4  alkoxy (preferably methoxy), —CN, C 1 -C 3  alkylsulfonyl (preferably methylsulfonyl), hydroxy, and SF 5 , wherein provided that the sum of x, y, and z1 or z2 is 1 to 4, x is 1, 2, or 3, y is 0 or 1, z1 is 0, 1, 2, or 3, and z2 is 1, 2, or 3. When —(CH 2 ) x —O y —(CH 2 ) z 1—C 6 -C 10  aryl has a substituent, the substituent is preferably on C 6 -C 10  aryl in the group, and when —(CH 2 ) x —O y —(CH 2 ) z2 -5- to 10-membered heteroaryl has a substituent, the substituent is preferably on 5- to 10-membered heteroaryl in the group. 
     Specific examples of R 8  include hydrogen, methyl, ethyl, i-propyl, n-propyl, n-butyl, 2-methylpropyl, 1-methylpropyl, neopentyl, (2-hydroxy-2-methyl-propyloxy)methyl, (2-(tert-butylamino)-2-oxoethoxy)methyl, 3,3-difluorobutyl, n-propoxymethyl, 3-methylbutoxymethyl, 1-hydroxyethyl, 2-methoxyethyl, 2-methylbutyl, 5,5-difluoropentyl, 3-methylamino-3-oxo-propyl, ((5-fluoripyridin-3-yl)methoxy)methyl, 4-(((allyloxy)carbonyl)amino)butyl, 2-hydroxy-2-oxoethyl, (5-fluoripyridin-3-yl)methyl, 2-(3,3-difluoropiperidinyl)ethyl, 2-(4,4-difluoropiperidinyl)-2-oxo-ethyl, 2-(allyloxy)-2-oxo-ethyl, phenoxymethyl, hydroxymethyl, 2-(tetrahydro-4H-pyran-4-ylidene)ethyl, 2-(tetrahydro-2H-pyran-4-yl)ethyl, 2-(1-(t-butoxycarbonyl)azetidin-3-ylidene)ethyl, 2-(1-(t-butoxycarbonyl)azetidin-3-yl)ethyl, 2-(3,3-difluoro-azetidin-1-yl)-2-oxoethyl, 2-(3,3-difluoro-azetidin-1-yl)-ethyl, 3-(dimethylamino)-3-oxopropyl, 3-(3,3-difluoro-azetidin-1-yl)-3-oxopropyl, 3-(azetidin-1-yl)-3-oxopropyl, 2-(piperidinyl)-2-oxo-propyl, 3-(pyrrolidin-1-yl)-3-oxopropyl, 3-(morpholin-1-yl)-3-oxopropyl, 2-(dimethylamino)-2-oxoethyl, 2-(azetidinyl)-2-oxo-ethyl, 2-(piperidinyl)-2-oxo-ethyl, 2-(pyrrolidinyl)-2-oxo-ethyl, 2-(morpholin-1-yl)-2-oxoethyl, allyl, 2-methylallyl, 3-methylbut-2-en-1-yl, pent-4-en-1-yl, propargyl, 3-allyloxy-3-oxo-propyl, cyclohexyl, cyclopentylmethyl, cyclopropylmethyl, benzyl, phenethyl, 4-chlorobenzyl, 3-cyanobenzyl, 4-ethynylbenzyl, 2-fluorobenzyl, 2-chlorobenzyl, 3-chlorobenzyl, 3-bromobenzyl, 4-bromobenzyl, 2-methylbenzyl, 3-methylbenzyl, 4-methylbenzyl, 4-methoxybenzyl, 3-(trifluoromethoxy)benzyl, 4-(trifluoromethoxy)benzyl, 3,4-difluorobenzyl, 4-iodobenzyl, 4-fluorobenzyl, 4-difluoromethylbenzyl, 3-fluoro-4-hydroxybenzyl, 4-(trifluoromethyl)benzyl, 2-trifluoromethylbenzyl, 2-methoxybenzyl, 3-trifluoromethylbenzyl, 2-(trifluoromethoxy)benzyl, 3-methoxybenzyl, 3-iodobenzyl, 3-fluorobenzyl, pyridin-3-ylmethyl, thiazol-4-ylmethyl, (6-cyanopyridin-3-yl)methyl, (6-methoxypyridin-3-yl)methyl, (6-trifluoromethylpyridin-3-yl)methyl, (5-methylpyridin-3-yl)methyl, (5-methoxypyridin-3-yl)methyl, (pyridin-4-yl)methyl, (6-methylpyridin-3-yl)methyl, 2-(pyridin-3-yl)ethyl, and 2-(pyridin-4-yl)ethyl. 
     In an embodiment, in formula (1), R 8 , together with R 5 , can form C 4 -C 8  alkylene. C 4 -C 8  alkylene is preferably —(CH 2 ) 8 —. 
     In an embodiment, in formula (1), R 8  and P 8 , together with the carbon atom to which R 8  is attached and the nitrogen atom to which P 8  is attached, can form a 4- to 7-membered saturated heterocyclic ring (preferably 4- or 5-membered saturated heterocyclic ring). The 4- to 7-membered saturated heterocyclic ring may be condensed with a saturated carbocyclic ring or an aromatic ring. The 4- to 7-membered saturated heterocyclic ring is optionally substituted with halogen, oxo, C 6 -C 10  aryl, 5- to 10-membered heteroaryl, 4- to 8-membered cyclic amino (wherein the cyclic amino is optionally substituted with one or more halogen atoms), or OS 8 . Here, S 8  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 7 -C 14  aralkyl (wherein the aralkyl is optionally substituted with one or more halogen atoms, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, or C 1 -C 6  haloalkoxy), or 5- to 10-membered heteroarylC 1 -C 6  alkyl. 
     When R 8  and P 8  form a 4- to 7-membered saturated heterocyclic ring, the 4- to 7-membered saturated heterocyclic ring is preferably an azetidine ring, a pyrrolidine ring, a piperidine ring, a piperazine ring, or a morpholine ring. These saturated heterocyclic rings may be condensed with a 3- to 8-membered saturated carbocyclic ring (preferably a cyclohexane ring) or a 6- to 10-membered aromatic ring (preferably a benzene ring). When the 4- to 7-membered saturated heterocyclic ring has one or more substituents, the 4- to 7-membered saturated heterocyclic ring is preferably substituted one or more halogen atoms, hydroxy, oxo, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  hydroxyalkoxy, C 6 -C 10  aryl, 5- to 10-membered heteroarylC 1 -C 6  alkoxy, C 7 -C 14  aralkoxy (wherein the C 7 -C 14  aralkoxy is optionally substituted with one or more halogen atoms, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, or C 1 -C 6  haloalkoxy), 4- to 8-membered cyclic amino optionally substituted with one or more halogen atoms, or 5- to 10-membered heteroaryl. More preferable examples of the substituent of the 4- to 7-membered saturated heterocyclic ring include halogen, hydroxy, oxo, ethoxy, 2-hydroxyethyl, phenyl, difluoroethoxy; benzyloxy optionally substituted with one or more substituents independently selected from the group consisting of one or more halogen atoms, methyl, trifluoromethyl, methoxy, and difluoromethoxy; 5- to 6-membered heteroarylmethoxy, 4- to 8-membered cyclic amino optionally substituted with one or more fluorine atoms, phenyl, and 5- to 6-membered heteroaryl. 
     In an embodiment, in formula (1), R 8  and Q 8 , together with the carbon atom to which they are attached, can form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring. 
     When R 8  and Q 8  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, the 3- to 8-membered alicyclic ring is preferably a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, or a cyclohexane ring, and the 4- to 7-membered saturated heterocyclic ring is preferably a tetrahydrofuran ring or a tetrahydropyran ring. 
     In an embodiment, in formula (1), except when R 8  and P 8  form a 4- to 7-membered saturated heterocyclic ring, P 8  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 1 -C 6  alkoxyC 2 -C 6  alkenyl, C 3 -C 8  cycloalkyl, 4- to 7-membered heterocyclyl, 4- to 7-membered heterocyclylC 1 -C 6  alkyl, C 6 -C 10  aryl, C 7 -C 14  aralkyl, 5- to 10-membered heteroaryl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen or C 1 -C 6  alkyl), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). 
     P 8  is preferably hydrogen, C 1 -C 6  alkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with one or more halogen atoms, hydroxy, di-C 1 -C 6  alkylaminocarbonyl, C 1 -C 6  alkoxy, or amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino)), aminocarbonylC 1 -C 6  alkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogen atoms), C 1 -C 6  aminoalkyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with one or more halogen atoms or C 1 -C 6  alkyl), C 2 -C 6  alkenyl, C 2 -C 6  hydroxyalkenyl, aminocarbonylC 2 -C 6  alkenyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), C 1 -C 6  alkoxyC 2 -C 6  alkenyl, C 3 -C 8  cycloalkyl optionally substituted with one or more halogen atoms, 4- to 7-membered heterocyclyl, 4- to 7-membered heterocyclylC 1 -C 6  alkyl, C 6 -C 10  aryl optionally substituted with one or more halogen atoms, C 7 -C 14  aralkyl, 5- to 10-membered heteroaryl, or 5- to 10-membered heteroarylC 1 -C 6  alkyl. 
     P 8  is more preferably hydrogen, C 1 -C 6  alkyl, C 1 -C 6  hydroxyalkyl; C 1 -C 4  alkoxyC 1 -C 2  alkyl optionally substituted with one or more fluorine atoms, hydroxy, dimethylaminocarbonyl, methoxy, amino, methylamino, or dimethylamino; dimethylaminocarbonylC 1 -C 4  alkyl, aminoC 1 -C 4  alkyl (wherein the amino is —NH 2 ), 4- to 8-membered cyclic aminoC 1 -C 4  alkyl optionally substituted with one or more fluorines or methyl, C 2 -C 3  alkenyl, C 2 -C 6  hydroxyalkenyl, dimethylaminocarbonylC 2 -C 3  alkenyl, methoxyC 2 -C 6  alkenyl, C 3 -C 8  cycloalkyl optionally substituted with one or more fluorine atoms, 4- to 7-membered heterocyclyl, 4- to 7-membered heterocyclylC 1 -C 2  alkyl, phenyl optionally substituted with one or more halogen atoms, benzyl, 5- to 6-membered heteroaryl, or 5- to 6-membered heteroarylC 1 -C 2  alkyl. 
     Specific examples of P 8  include hydrogen, methyl, ethyl, n-butyl, allyl, 2-hydroxyethyl, 2-ethoxyethyl, 2-(dimethylaminocarbonylmethoxy)ethyl, 2-(2-hydroxy-2-methylpropoxy)ethyl, 4-aminobutyl, 2-piperazin-1-ylethyl, 2-(4-methylpiperazin-1-yl)ethyl, 2-(2,2,2-trifluoroethoxy)ethyl, 2-(2-methoxyethoxy)ethyl, 2-(2,2-difluoroethoxy)ethyl, 2-(2-aminoethoxy)ethyl, 2-[2-(methylamino)ethoxy]ethyl, 2-[2-(dimethylamino)ethoxy]ethyl, 5-hydroxypentyl, phenyl, 3-chlorophenyl, 4-chlorophenyl, benzyl, (E)-3-(dimethylaminocarbonyl)-prop-2-en-1-yl, (E)-5-hydroxypent-2-en-1-yl, (E)-4-hydroxy-4-methyl-pent-2-en-1-yl, (E)-5-hydroxy-5-methyl-hex-2-en-1-yl, (E)-4-methoxybut-2-en-1-yl, 3-(dimethylaminocarbonyl)propyl, 2,2-difluorospiro[3.3]heptan-6-yl, 3-thienyl, 3-pyridylmethyl, 2-oxaspiro[3.3]heptan-6-yl, oxetan-3-ylmethyl, 2-(azetidin-3-yl)ethyl, 2-(4,4-difluoro-1-piperidyl)ethyl, and 3-(4,4-difluoro-1-piperidyl)propyl. 
     In an embodiment, except when R 8  and Q 8  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 8  is hydrogen or C 1 -C 6  alkyl, and preferably hydrogen. 
     Specific examples of core 8 include MeAla, Ala, Pic(2), MeLeu, EtAla, MeSer(tBuOH), MeSer(NtBu-Aca), MeAla(cPent), MeAla(cPr), MeNva, MeNle, Val, Leu, MeNva(5-F2), MeSer(nPr), MeHnl(7-F2), MeSer(iPen), MeThr, MeHse(Me), Ile, Nle, PRA, Chg, Abu, Hnl(7-F2), Ser(iPen), Algly, Pregly, EtGly, nBuGly, (EtOEt)NGly, Pro, Aze(2), MeGln(Me), MePhe, MePhe(4-Cl), MePhe(3-CN), MePhe(4-CN), MePhe(2-F), MePhe(3-F), MePhe(4-F), MePhe(2-Cl), MePhe(3-Cl), MePhe(3-Br), MePhe(4-Br), MePhe(2-Me), MePhe(3-Me), MePhe(4-Me), MeTyr(Me), MePhe(3-OCF3), MePhe(4-OCF3), MeAlgly, MePhe(34-F2), MeAla(3-Pyr), MePhe(4-I), Phe(4-Me), D-MeAla, Phe(3-Me), Phe, Hph, Phe(4-F), Phe(2-F), Hyp(Et), Tle, Pro(4-F2), Ser(tBuOH), Ser(NtBu-Aca), Ser(3-F-5-Me-Pyr), Glu(OAl), Oic, Hyp, cisHyp, Lys(Alloc), Phe(4-CHF2), Hyp(Bzl), cisHyp(Et), Hyp(Bzl(2-Cl)), cisHyp(Bzl(2-Cl)), cisHyp(Bzl(3-Cl)), cisHyp(Bzl(4-Cl)), Hyp(Bzl(3-Cl)), Hyp(Bzl(4-Cl)), Hyp(Bzl(2-Me)), Hyp(Bzl(3-Me)), Hyp(Bzl(3-OMe)), Hyp(Bzl(4-Me)), Hyp(Bzl(4-OCHF2)), cisHyp(Bzl(2-Me)), cisHyp(Bzl(3-Me)), cisHyp(Bzl(3-OMe)), cisHyp(Bzl(4-Me)), cisHyp(Bzl(4-OCHF2)), Methagly, MeAsp, Pro(4-keto), Pic(2)(4-Oxo), Mor(3), Thiopro, MeAla(4-Thz), MeSer(3-F-5-Me-Pyr), MeTyr(3-F), MeAla(3-Pyr-4-CN), Ahpe(2), Hyp(3-Me-Pyr), cisHyp(3-Me-Pyr), cisHyp(Et(2-F2)), Hyp(Et(2-F2)), Tyr(Me), Phe(4-CF3), Phe(4-Cl), Phe(2-CF3), Phe(2-Cl), Phe(2-Me), Phe(2-OMe), Phe(3-CF3), MeAbu(pip-3-F2), MeAsn(pip-4-F2), Pro(4-pip-4-F2), cisPro(4-pip-4-F2), MeAsp(OAl), Pro(4R-Tri), Pro(4S-Tri), Ser(Ph), IDC, Pro(4R-Ph), Pro(4S-Ph), MeAla(3-Pyr-4-OMe), MeAla(3-Pyr-4-CF3), MeAla(3-Pyr-5-Me), MeAla(3-Pyr-5-OMe), MeAla(4-Pyr), MeAla(3-Pyr-4-Me), Hyp(3-thie-Me), PhGly, cisHyp(2-EtOH), Hyp(2-EtOH), Phe(2-OCF3), BnGly, (3-Thienyl)Gly, (Ph-3-Cl)Gly, (Ph-4-Cl)Gly, (F2cBucBu)Gly, (OxeMe)Gly, (OxecBu)Gly, D-Ala, D-MeSer(iPen), D-MeSer, D-Mor(3), D-MePhe, D-MeAbu, MePhe(4-CHF2), MeAbu(3-Pyr), MeAbu(4-Pyr), MeAbu(THPdene), MeAbu(THP), MeAbu(BocAzedene), MeAbu(BocAze), (pip(4-F2)Et)Gly, (pip(4-F2)nPr)Gly, (Et(2-F2)OEt)Gly, (MeOEtOEt)Gly, (Et(2-F3)OEt)Gly, (4-pyr-Et)Gly, (3-pyr-Et)Gly, (4-pyr-Me)Gly, (3-pyr-Me)Gly, AllylGly, (HOEt)Gly, (HOiPrallyl)Gly, (DMFallyl)Gly, (HOEtallyl)Gly, (5-OH-nPent)Gly, MeAsn(Aze-3-F2), MeAbu(Aze-3-F2), (Me2NCOnPr)Gly, (HOtBuallyl)Gly, (HOtBuOEt)Gly, (DMAOEt)Gly, (MeOMeallyl)Gly, MeGln(Me2), MeGln(Aze-3-F2), MeGln(Aze), MeGln(pip), MeGln(pyrro), MeGln(mor), MeAsn(Me2), MeAsn(Aze), MeAsn(pip), MeAsn(pyrro), MeAsn(mor), MePhe(3-OMe), MePhe(3-I), EtPhe(2-Cl), (4-Me-piz-Et)Gly, (Aze(3)Et)Gly, (H2NEtOEt)Gly, (H2NnBu)Gly, (Me2NEtOEt)Gly, (MeNEtOEt)Gly, and (piz-Et)Gly. 
     In an embodiment, in formula (1), R 9  is hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 7 -C 14  aralkyl, or 5- to 10-membered heteroarylC 1 -C 6  alkoxyC 1 -C 6  alkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), and C 1 -C 6  alkylsulfonyl. 
     R 9  is preferably hydrogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkenyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), hydroxy, or 5- to 10-membered heteroaryl optionally substituted with one or more halogen atoms), C 3 -C 8  cycloalkylC 1 -C 6  alkyl, or C 7 -C 14  aralkyl (wherein the C 7 -C 14  aralkyl is optionally substituted with one or more groups independently selected from the group consisting of one or more halogen atoms, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, and cyano). 
     R 9  is more preferably hydrogen, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 3  alkenyl; C 1 -C 6  alkoxyC 1 -C 2  alkyl optionally substituted with mono-C 1 -C 4  alkylaminocarbonyl, hydroxy, or 5- to 6-membered heteroaryl optionally substituted with one or more fluorine atoms; and benzyl or phenethyl optionally substituted with one or more groups independently selected from the group consisting of C 3 -C 6  cycloalkylC 1 -C 2  alkyl, halogen, methyl, trifluoromethyl, methoxy, trifluoromethoxy, and cyano. 
     More specific examples of R 9  include hydrogen, methyl, ethyl, i-propyl, 2-methylpropyl, 2,2,2-trifluoroethyl, 5,5-difluoropentyl, methoxymethyl, n-propoxymethyl, 3-methylbutoxymethyl, 3-(dimethylamino)3-oxopropyl, (2-hydroxy-2-methyl-propyloxy)methyl, (2-(tert-butylamino)-2-oxoethoxy)methyl, (5-fluoropyridin-3-yl)methyl, allyl, cyclohexylmethyl, benzyl, phenethyl, 2-chlorobenzyl, 3-chlorobenzyl, 4-chlorobenzyl, 2-fluorobenzyl, 3-fluorobenzyl, 4-fluorobenzyl, 2-methylbenzyl, 4-methylbenzyl, 2-methoxybenzyl, 4-methoxybenzyl, 2-(trifluoromethyl)benzyl, 3-(trifluoromethyl)benzyl, 4-(trifluoromethyl)benzyl, 2-(trifluoromethoxy)benzyl, 3-(trifluoromethoxy)benzyl, and 4-(trifluoromethoxy)benzyl. 
     In an embodiment, in formula (1), R 9  and P 9 , together with the carbon atom to which R 9  is attached and the nitrogen atom to which P 9  is attached, can form a 4- to 7-membered saturated heterocyclic ring. 
     When R 9  and P 9  form a 4- to 7-membered saturated heterocyclic ring, the 4- to 7-membered saturated heterocyclic ring is preferably an azetidine ring, a pyrrolidine ring, a piperidine ring, a piperazine ring, or a morpholine ring. 
     In an embodiment, in formula (1), R 9  and Q 9 , together with the carbon atom to which they are attached, can form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring. 
     When R 9  and Q 9  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, the 3- to 8-membered alicyclic ring is preferably a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, or a cyclohexane ring, and the 4- to 7-membered saturated heterocyclic ring is preferably a tetrahydrofuran ring or a tetrahydropyran ring. 
     In an embodiment, in formula (1), except when R 9  and P 9  form a 4- to 7-membered saturated heterocyclic ring, P 9  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). P 9  is preferably hydrogen or C 1 -C 6  alkyl, and more preferably hydrogen, methyl, n-propyl, or n-butyl. 
     In an embodiment, except when R 9  and Q 9  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 9  is hydrogen or C 1 -C 6  alkyl, and preferably hydrogen or methyl. 
     Regarding R 9  and Q 9 , preferably, R 9  is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, or C 7 -C 14  aralkyl, and Q 9  is C 1 -C 6  alkyl; or R 9  and Q 9 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring. 
     Specific examples of core 9 include MeAla, Ala, MeLeu, MeCha, MeVal, MeSer(tBuOH), MeSer(NtBu-Aca), Val, Leu, MeSer(nPr), MeHnl(7-F2), MeSer(iPen), Ser(nPr), Abu(4-F3), Abu, Ser(Me), Gly, nBuGly, nPrGly, MePhe, MeHph, MePhe(4-Cl), MePhe(2-F), MePhe(3-F), MePhe(4-F), MePhe(2-Cl), MePhe(3-Cl), MePhe(2-Me), MePhe(4-Me), MePhe(2-CF3), MePhe(3-CF3), MePhe(4-CF3), MeTyr(Me), MePhe(2-OCF3), MePhe(3-OCF3), MePhe(4-OCF3), D-Pro, Phe, Ser(NtBu-Aca), MeSer(3-F-5-Me-Pyr), D-Ala, MeGln(Me2), MeAib, Aib, cLeu, cHex, cVal, (Me)Phe, MecLeu, D-(Me)Abu, D-(Me)Algly, 1-ACPrC, (Me)Abu, (Me)Algly, (Me)Leu, Athpc, MePhe(2-OMe), Me(Me)Phe, D-Val, and D-Algly. 
     In an embodiment, in formula (1), R 10  is C 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, or C 7 -C 14  aralkyl, each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, and C 1 -C 6  alkylsulfonyl. 
     R 10  is preferably C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 1 -C 6  alkylsulfonylC 1 -C 6  alkyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with one or more halogen atoms, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkylC 1 -C 6  alkyl, C 3 -C 8  cycloalkoxyC 1 -C 6  alkyl, or C 7 -C 14  aralkyl. 
     R 10  is more preferably C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 1 -C 4  hydroxyalkyl, methylsulfonylC 1 -C 2  alkyl, C 2 -C 3  alkynyl, C 1 -C 4  alkoxyC 1 -C 2  alkyl optionally substituted with one or more fluorine atoms, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkylC 1 -C 2  alkyl, C 3 -C 6  cycloalkoxyC 1 -C 2  alkyl, benzyl, or phenethyl. 
     More specific examples of R 10  include methyl, ethyl, n-propyl, i-propyl, 2-methylpropyl, 1-methylpropyl, n-butyl, 2-methylbutyl, 3-methylbutyl, n-pentyl, propargyl, 3,3-difluorobutyl, 5,5-difluoropentyl, methoxymethyl, 1-methoxyethyl, 2-methoxyethyl, n-propoxymethyl, 1-hydroxyethyl, cyclopropoxymethyl, cyclobutoxymethyl, (2,2,2-trifluoroethoxy)methyl, 2-methylsulfonylethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, benzyl, and phenethyl. 
     In an embodiment, in formula (1), R 10  and P 10 , together with the carbon atom to which R 10  is attached and the nitrogen atom to which P 10  is attached, can form a 4- to 7-membered saturated heterocyclic ring. 
     When R 10  and P 10  form a 4- to 7-membered saturated heterocyclic ring, the 4- to 7-membered saturated heterocyclic ring is preferably an azetidine ring, a pyrrolidine ring, a piperidine ring, a piperazine ring, or a morpholine ring. 
     In an embodiment, in formula (1), R 10  and Q 10 , together with the carbon atom to which they are attached, can form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring. 
     When R 10  and Q 10  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, the 3- to 8-membered alicyclic ring is preferably a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, or a cyclohexane ring, and the 4- to 7-membered saturated heterocyclic ring is preferably a tetrahydrofuran ring or a tetrahydropyran ring. 
     In an embodiment, in formula (1), except when R 10  and P 10  form a 4- to 7-membered saturated heterocyclic ring, P 10  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). P 10  is preferably hydrogen or C 1 -C 2  alkyl, and specific examples include hydrogen and methyl. 
     In an embodiment, except when R 10  and Q 10  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 10  is hydrogen or C 1 -C 6  alkyl, and preferably hydrogen. 
     Specific examples of core 10 include MeAla, MeLeu, MeCha, MeVal, MeAla(cPent), MeAla(cBu), MeAla(cPr), MeChg, MeGly(cPent), MeGly(cBu), MeGly(cPr), MeAbu, MeNva, MeNle, Val, Leu, MeNva(5-F2), MeHle, MeIle, MeSer(nPr), MeSer(cPr), MeHnl, MeHnl(7-F2), MePRA, MeSer(Me), MeThr, MeSer(cBu), MeSer(Tfe), MeThr(Me), MeHse(Me), MeMet(O2), Ile, Nle, Chg, Ala(cBu), Gly(cPent), Hle, Nva, Phe, and Hph. 
     In an embodiment, in formula (1), R 11  is hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl, C 7 -C 14  aralkyl, or aminocarbonyl (wherein the amino is —NH 2 , mono C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), each of which is optionally substituted with one or more groups independently selected from the group consisting of halogen, oxo, hydroxy, C 1 -C 6  alkyl, 4- to 7-membered heterocyclyl, aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino), and C 1 -C 6  alkylsulfonyl; or R 11  is a peptide chain containing 1 to 4 amino acid residues. When R 11  is a peptide chain containing 1 to 4 amino acid residues, the 1 to 4 amino acid residues constituting the peptide chain may be natural amino acid residues or non-natural amino acid residues, and may be the same or different. 
     When core 11 is α-amino acid (i.e., L 11  is a single bond), R 11  is preferably hydrogen, C 1 -C 6  alkoxyC 1 -C 6  alkyl optionally substituted with hydroxy, or C 7 -C 14  aralkyl optionally substituted with one or more halogen atoms. 
     When core 11 is α-amino acid, R 11  is more preferably hydrogen, C 1 -C 6  alkoxyC 1 -C 2  alkyl optionally substituted with hydroxy, or benzyl optionally substituted with fluorine, and specific examples include hydrogen, (2-hydroxy-2-methyl-propyloxy)methyl, benzyl, 3-fluorobenzyl, and 4-fluorobenzyl. 
     When core 11 is β-amino acid (i.e., L 11  is —CHM 11 -), R 11  is preferably hydrogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxyC 1 -C 6  alkyl (wherein the C 1 -C 6  alkoxyC 1 -C 6  alkyl is optionally substituted with hydroxy or aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino)), C 7 -C 14  aralkyl optionally substituted with one or more halogen atoms, or aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, and the cyclic amino may be further substituted with one or more halogen atoms, one or more oxo groups, one or more C 1 -C 6  alkyl groups, or 4- to 7-membered heterocyclyl). 
     When core 11 is β-amino acid, R 11  is more preferably hydrogen, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 3  alkenyl, C 2 -C 3  alkynyl, C 1 -C 6  alkoxyC 1 -C 2  alkyl optionally substituted with mono-C 1 -C 4  alkylaminocarbonyl, dimethylaminocarbonyl; 4- to 8-membered cyclic aminocarbonyl optionally substituted with one or more fluorine atoms, C 1 -C 4  alkyl, or 4- to 7-membered heterocyclyl; benzyl or phenethyl. 
     When core 11 is β-amino acid, specific examples of R 11  include hydrogen, methyl, isobutyl, trifluoromethyl, allyl, prop-2-yn-1-yl, (isopentyloxy)methyl, {2-(t-butylamino)-2-oxoethoxy}methyl, dimethylaminocarbonyl, azetidinylcarbonyl, pyrrolidinylcarbonyl, 3,3-dimethylpyrrolidinylcarbonyl, 3,3,4,4-tetrafluoropyrrolidinylcarbonyl, 4-methylpiperidinylcarbonyl, 4-(t-butyl)-piperidinylcarbonyl, 3,3,4,4,5,5-hexafluoropiperidinylcarbonyl, 3,3-difluoropiperidinylcarbonyl, 4,4-difluoropiperidinylcarbonyl, piperidinylcarbonyl, morpholinocarbonyl, oxazolidin-3-ylcarbonyl, 3-oxa-8-azabicyclo[3.2.1]octan-8-ylcarbonyl, 1,1-dioxidethiomorpholinylcarbonyl, 1-(oxetan-3-yl)-piperazin-4-ylcarbonyl, and phenethyl. 
     When L 11  of core 11 is —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m , or —(CH 2 ) n S(O) 2 (CH 2 ) m —, R 11  is preferably aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). 
     In an embodiment, in formula (1), R 11  and P 11 , together with the carbon atom to which R 11  is attached and the nitrogen atom to which P 11  is attached, can form a 4- to 7-membered saturated heterocyclic ring. 
     When L 11  and P 11  form a 4- to 7-membered saturated heterocyclic ring, the 4- to 7-membered saturated heterocyclic ring is preferably an azetidine ring, a pyrrolidine ring, a piperidine ring, a piperazine ring, or a morpholine ring. 
     In an embodiment, in formula (1), R 11  and Q 11 , together with the carbon atom to which they are attached, can form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring. 
     When R 11  and Q 11  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, the 3- to 8-membered alicyclic ring is preferably a cyclopropane ring, a cyclobutane ring, a cyclopentane ring, or a cyclohexane ring, and the 4- to 7-membered saturated heterocyclic ring is preferably a tetrahydrofuran ring or a tetrahydropyran ring. 
     In an embodiment, in formula (1), when core 11 is β-amino acid, R 11  and M 11 , together with the carbon atom to which R 11  is attached and the carbon atom to which M 11  is attached, can form a 3- to 8-membered alicyclic ring. 
     When R 11  and M 11  form a 3- to 8-membered alicyclic ring, the 3- to 8-membered alicyclic ring is preferably a cyclopentane ring or a cyclohexane ring. 
     In an embodiment, in formula (1), when core 11 is β-amino acid, M 11  is hydrogen except when R 11  and M 11  form a 3- to 8-membered alicyclic ring. 
     In an embodiment, in formula (1), except when R 11  and P 11  form a 4- to 7-membered saturated heterocyclic ring, P 11  is hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, C 1 -C 6  alkoxy, amino (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino, each of which is optionally substituted with halogen), and aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). 
     P 11  is preferably hydrogen or C 1 -C 6  alkyl. Specific examples of such P 11  include hydrogen, methyl, ethyl, and n-propyl. 
     In an embodiment, except when R 11  and Q 11  form a 3- to 8-membered alicyclic ring or a 4- to 7-membered saturated heterocyclic ring, Q 11  is hydrogen or C 1 -C 6  alkyl, and preferably hydrogen. 
     In an embodiment, R 11  is preferably —CONR 11A R 11B , wherein R 11A  and R 11B  are each independently hydrogen or C 1 -C 6  alkyl (preferably methyl), or R 11A  and R 11B , together with the nitrogen atom to which they are attached, form a 4- to 8-membered saturated heterocyclic ring. The 4- to 8-membered saturated heterocyclic ring is optionally substituted with one or more groups independently selected from the group consisting of one or more halogen atoms (preferably fluorine), one or more oxo groups, one or more C 1 -C 6  alkyl groups (preferably C 1 -C 4  alkyl), and 4- to 7-membered heterocyclyl (preferably oxetan-3-yl). 
     When core 11 is α-amino acid, specific examples of core 11 include MeSer(tBuOH), MeGly, MePhe, MePhe(3-F), MePhe(4-F), and D-MePhe. 
     When core 11 is β-amino acid, specific examples of core 11 include bAla, bMeAla, 2-ACHxC, 2-ACPnC, 3-CF3-bAla, Asp-mor, Asp-mor(26-bicyc), Asp-mor(SO2), Asp-NMe2, Asp-oxz, Asp-pip, Asp-pip(345-F6), Asp-pip(4-Me), Asp-pip-tBu, Asp-piz(oxe), Asp-pyrro, Asp-pyrro(34-F4), Asp-pyrro(3-Me2), D-(Propargyl)Gly-(C#CH2), D-3-Abu, D-3-MeAbu, D-Gly(Allyl)-(C#CH2), D-Hph-(C#CH2), D-Leu-(C#CH2), D-MeAsp-pyrro, D-MeLeu-(C#CH2), D-Pic(2)-(C#CH2), D-Pro-(C#CH2), D-Ser(iPen)-(C#CH2), D-Ser(NtBu-Aca)-(C#CH2), EtAsp-pip, MeAsp-aze, MeAsp-mor, MeAsp-mor(26-bicyc), MeAsp-mor(SO2), MeAsp-NMe2, MeAsp-oxz, MeAsp-pip, MeAsp-pip(345-F6), MeAsp-pip(3-F2), MeAsp-pip(4-F2), MeAsp-pip(4-Me), MeAsp-piz(oxe), MeAsp-pyrro, MeAsp-pyrro(34-F4), MeAsp-pyrro(3-Me2), and nPrAsp-pip. 
     When L 11  is —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m , or —(CH 2 ) n S(O) 2 (CH 2 ) m —, specific examples of core 11 include MeCys(AcOH)—NMe2. 
     In an embodiment, in formula (1), at least three of P 1  to P 11  are not hydrogen. 
     In an embodiment, in formula (1), at least three, at least four, at least five, or at least six of P 1  to P 11  are preferably C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is preferably methyl or ethyl. 
     In an embodiment, the present invention can be a compound having formula (1) wherein one of —CO-L 1 - and —CO-L 11 -is replaced with —(CH 2 ) n C≡CCH 2 S(CH 2 ) m —, —(CH 2 ) n CH═CHCH 2 S(CH 2 ) m —, or —(CH 2 ) n+3 S(CH 2 ) m —, wherein n is 1, 2, or 3, and m is 1 or 2. —S— may be oxidized to be —S(O)— or —S(O) 2 —. Here, when —CO-L 1 -is replaced with —(CH 2 ) n C≡CCH 2 S(CH 2 ) m —, —(CH 2 ) n CH═CHCH 2 S(CH 2 ) m —, or —(CH 2 ) n+3 S(CH 2 ) m —, L 11  is a single bond, and when —CO-L 11 -is replaced with —(CH 2 ) n C≡CCH 2 S(CH 2 ) m —, —(CH 2 ) n CH═CHCH 2 S(CH 2 ) m —, or —(CH 2 ) n+3 S(CH 2 ) m —, L 1  is a single bond. Groups other than L 1  and L 11  in formula (1) are as described above. 
     In an embodiment, the present invention relates to a cyclic peptide compound represented by formula (1′) below or a salt thereof, or a solvate thereof. 
     
       
         
         
             
             
         
       
     
     In formula (1′), 
     L 11  is —CHM 1 -, —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m —, or —(CH 2 ) n S(O) 2 (CH 2 ) m —, 
     n and m are each independently 1 or 2, 
     the definitions of R 2  to R 11 , P 2  to P 11 , Q 2  to Q 11 , and M 1  are the same as the definitions of R 2  to R 11 , P 2  to P 11 , Q 2  to Q 11 , and M 11  in formula (1), respectively. 
     In formula (1′), the ring is composed of 10 amino acid residues. As in formula (1), the amino acid residue having P 2 , Q 2 , and R 2  in the formula may be referred to as core 2, the amino acid residue having P 3 , Q 3 , and R 3  as core 3, the amino acid residue having P 4 , Q 4 , and R 4  as core 4, the amino acid residue having P 5 , Q 5 , and R 5  as core 5, the amino acid residue having P 6 , Q 6 , and R 6  as core 6, the amino acid residue having P 7 , Q 7 , and R 7  as core 7, the amino acid residue having P 8 , Q 8 , and R 8  as core 8, the amino acid residue having P 9 , Q 9 , and R 9  as core 9, the amino acid residue having P 10 , Q 10 , and R 10  as core 10, and the amino acid residue having P 1 , Q 11 , R 11 , and L 11  as core 11. 
     In an embodiment, in formula (1′), L 11  is —CHM 11 -, —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m —, or —(CH 2 ) n S(O) 2 (CH 2 ) m —. M 11  is the same as M 11  in formula (1). 
     When L 11  is —CHM 11 -, M 11  can be hydrogen, or M 11  can, together with R 11 , the carbon atom to which R 11  is attached, and the carbon atom to which M 11  is attached, form a 3- to 8-membered alicyclic ring. The 3- to 8-membered alicyclic ring is preferably a cyclopentane ring or a cyclohexane ring. 
     When L 11  is —(CH 2 ) n S(CH 2 ) m —, specific examples of —(CH 2 ) n S(CH 2 ) m — include —CH 2 SCH 2 —, —CH 2 CH 2 SCH 2 —, —CH 2 SCH 2 CH 2 —, and —CH 2 CH 2 SCH 2 CH 2 —. 
     When L 11  is —(CH 2 ) n S(O)(CH 2 ) m —, specific examples of —(CH 2 ) n S(O)(CH 2 ) m — include —CH 2 S(O)CH 2 —, —CH 2 CH 2 S(O)CH 2 —, —CH 2 S(O)CH 2 CH 2 —, and —CH 2 CH 2 S(O)CH 2 CH 2 —. 
     When L 11  is —(CH 2 ) n S(O) 2 (CH 2 ) m —, specific examples of —(CH 2 ) n S(O) 2 (CH 2 ) m — include —CH 2 S(O) 2 CH 2 —, —CH 2 CH 2 S(O) 2 CH 2 —, —CH 2 S(O) 2 CH 2 CH 2 —, and —CH 2 CH 2 S(O) 2 CH 2 CH 2 —. 
     When L 11  is —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m , or —(CH 2 ) n S(O) 2 (CH 2 ) m —, R 11  is preferably aminocarbonyl (wherein the amino is —NH 2 , mono-C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, or 4- to 8-membered cyclic amino). 
     When L 11  is —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m , or —(CH 2 ) n S(O) 2 (CH 2 ) m —, R 11  is more preferably —CONR 11A R 11B , wherein R 11A  and R 11B  are each independently hydrogen or C 1 -C 6 alkyl (preferably methyl), or R 11A  and R 11B , together with the nitrogen atom to which they are attached, form a 4- to 8-membered saturated heterocyclic ring. The 4- to 8-membered saturated heterocyclic ring is optionally substituted with one or more groups independently selected from the group consisting of one or more halogen atoms (preferably fluorine atom(s)), one or more oxo groups, one or more C 1 -C 6  alkyl groups (preferably C 1 -C 4  alkyl group(s)), and 4- to 7-membered heterocyclyl (preferably oxetan-3-yl). Specific examples of R 11  include dimethylaminocarbonyl. 
     When L 11  is —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m , or —(CH 2 ) n S(O) 2 (CH 2 ) m —, Q 11  is preferably hydrogen or C 1 -C 6  alkyl, and more preferably hydrogen. 
     When L 11  is —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m , or —(CH 2 ) n S(O) 2 (CH 2 ) m —, P 11  is preferably hydrogen or C 1 -C 6  alkyl. Specific examples of such P 11  include hydrogen, methyl, ethyl, and n-propyl. 
     When L 11  is —(CH 2 ) n S(CH 2 ) m —, —(CH 2 ) n S(O)(CH 2 ) m , or —(CH 2 ) n S(O) 2 (CH 2 ) m —, specific examples of core 11 include MeCys(AcOH)—NMe2. 
     Preferable groups in each of cores 2 to 11 in formula (1′) may be the same as the preferable groups in each corresponding core in formula (1). Further, the specific amino acids listed above as cores 2 to 11 of formula (1) can be used as amino acids of each corresponding core of formula (1′). 
     Specific examples of the cyclic peptide compound represented by formula (1′) include the following:
     (2172) (3S,9S,18S,24R,27S,33S)-18-[(2S)-butan-2-yl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-27-cyclopentyl-N,N,7,10,13,16,25,28-octamethyl-2,5,8,11,14,17,20,26,29,32-decaoxospiro[22-thia-1,4,7,10,13,16,19,25,28,31-decazabicyclo[31.3.0]hexatriacontane-30,1′-cyclopentane]-24-carboxamide, and (2173) (3S,9S,18S,24R,27S,33S)-18,27-bis[(2S)-butan-2-yl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-N,N,7,10,13,16,25,28-octamethyl-9-[(4-methylphenyl)methyl]-2,5,8,11,14,17,20,26,29,32-decaoxospiro[22-thia-1,4,7,10,13,16,19,25,28,31-decazabicyclo[31.3.0]hexatriacontane-30,1′-cyclopentane]-24-carboxamide.   

     In an embodiment, the present invention can be a cyclic peptide compound represented by formula (2) below that further specifies formula (1) above. 
     
       
         
         
             
             
         
       
     
     The definition of each group in formula (2) is the same as the definition of each group in formula (1). The cyclic peptide compound represented by formula (2) preferably has each of the following groups. 
     R 1  is C 1 -C 6  alkyl (preferably C 1 -C 4  alkyl, and more preferably methyl or 2-methylpropyl), and P 1  is C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), and/or 
     R 2  is C 1 -C 6  alkyl (preferably C 3 -C 6  alkyl, and more preferably 1-methylpropyl), and P 2  is hydrogen or C 1 -C 6  alkyl (preferably hydrogen or C 1 -C 3  alkyl, and more preferably hydrogen or methyl), and/or 
     R 3  is hydrogen or C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), and P 3  is hydrogen or C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), and/or 
     R 4  is hydrogen, and P 4  is C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), or R 4  and P 4 , together with the carbon atom to which R 4  is attached and the nitrogen atom to which P 4  is attached, form a 4- to 7-membered saturated heterocyclic ring (preferably, an azetidine ring, a pyrrolidine ring, or a piperidine ring, and more preferably an azetidine ring or a pyrrolidine ring), and/or 
     R 5  is C 1 -C 6  alkoxyC 1 -C 6  alkyl (preferably C 2 -C 6 alkoxy C 1 -C 2  alkyl, and more preferably C 3 -C 5  alkoxymethyl); C 7 -C 14  aralkyl (preferably benzyl or phenethyl, and more preferably benzyl) optionally substituted with a group independently selected from the group consisting of halogen (preferably fluorine or chlorine), C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), C 1 -C 6  haloalkyl (preferably C 1 -C 3  fluoroalkyl, and more preferably trifluoromethyl), and C 1 -C 6  alkoxy (preferably C 1 -C 3  alkoxy, and more preferably methoxy); C 3 -C 8  cycloalkyl (preferably C 3 -C 6  cycloalkyl, and more preferably C 5 -C 6  cycloalkyl), or C 3 -C 8  cycloalkylC 1 -C 6  alkyl (preferably C 3 -C 6  cycloalkylC 1 -C 2  alkyl, more preferably C 5 -C 6  cycloalkylmethyl, and even more preferably cyclohexylmethyl), and P 5  is C 1 -C 2  alkyl (preferably methyl or ethyl), and/or 
     R 6  is hydrogen or C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), and P 6  is C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl or ethyl), or R 6  and P 6 , together with the carbon atom to which R 6  is attached and the nitrogen atom to which P 6  is attached, form a 4- to 7-membered saturated heterocyclic ring (preferably, an azetidine ring, a pyrrolidine ring, or a piperidine ring, and more preferably a pyrrolidine ring), and/or 
     R 7  is C 7 -C 14  aralkyl (preferably benzyl or phenethyl) optionally substituted with 1 to 5 (preferably 1 to 3) groups independently selected from the group consisting of halogen (preferably fluorine, chlorine, or iodine) and C 1 -C 6  haloalkyl (preferably C 1 -C 3  fluoroalkyl, and more preferably trifluoromethyl), P 7  is hydrogen, and Q 7  is hydrogen, and/or 
     R 8  is C 1 -C 6  alkyl (preferably C 1 -C 4  alkyl, and more preferably 2-methylpropyl, isopropyl, or n-butyl), C 2 -C 6  alkynyl (preferably C 2 -C 3  alkynyl, and more preferably propargyl), 4- to 8-membered cyclic aminocarbonylC 1 -C 6  alkyl (preferably 4- to 8-membered cyclic aminocarbonylC 1 -C 2  alkyl, and more preferably 4- to 8-membered cyclic aminocarbonylmethyl) optionally substituted with 1 to 5 (preferably 1 to 3) fluorine atoms, 5- to 10-membered heteroarylC 1 -C 6  alkyl (preferably 5- to 10-membered heteroarylC 1 -C 2  alkyl, and more preferably 5- to 10-membered heteroarylmethyl), or C 7 -C 14  aralkyl (preferably benzyl or phenethyl) optionally substituted with 1 to 3 halogen atoms (preferably chlorine), and P 8  is hydrogen, C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), 4- to 8-membered cyclic aminoC 1 -C 6  alkyl optionally substituted with 1 to 5 (preferably 1 to 3) C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl) (preferably piperazylC 1 -C 2  alkyl), 4- to 7-membered heterocyclylC 1 -C 6  alkyl (preferably 4- to 7-membered heterocyclylC 1 -C 2  alkyl, more preferably azetidylethyl), C 1 -C 6  alkoxyC 1 -C 6  alkyl substituted with amino (NH 2 ), C 1 -C 6  alkylamino (preferably methylamino), or di-C 1 -C 6  alkylamino (preferably dimethylamino) (preferably C 1 -C 3  alkoxyC 1 -C 2  alkyl, and more preferably ethoxyethyl), or amino (NH 2 ) C 1 -C 6  alkyl; or R 8  and P 8 , together with the carbon atom to which R 8  is attached and the nitrogen atom to which P 8  is attached, form a 4- to 7-membered saturated heterocyclic ring (preferably an azetidine ring, a pyrrolidine ring, or a piperidine ring, and more preferably an azetidine ring or a pyrrolidine ring), wherein the 4- to 7-membered saturated heterocyclic ring is optionally substituted with 1 to 5 (preferably 1 to 3) halogen atoms (preferably fluorine) or C 1 -C 6  alkoxy (preferably C 1 -C 3  alkoxy, and more preferably methoxy or ethoxy), and/or 
     R 9  is benzyl, and Q 9  is hydrogen; or R 9  and Q 9  are each independently C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), or R 9  and Q 9 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring (preferably a 3- to 6-membered alicyclic ring, more preferably a cyclobutane ring or a cyclopentane ring), and P 9  is hydrogen or C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), and/or 
     R 10  is C 1 -C 6  alkyl (preferably C 1 -C 4  alkyl, and more preferably isopropyl, 1-methylpropyl, or 2-methylpropyl) or C 3 -C 8  cycloalkyl (preferably C 3 -C 6  cycloalkyl, and more preferably cyclopentyl or cyclohexyl), and P 10  is hydrogen or C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), and/or 
     R 11  is C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), di-C 1 -C 6  alkylaminocarbonyl (preferably di-C 1 -C 3  alkylaminocarbonyl, and more preferably dimethylaminocarbonyl), or 4- to 8-membered cyclic aminocarbonyl (preferably azetidinylcarbonyl, pyrrolidinylcarbonyl, piperidinylcarbonyl, 4-morpholinylcarbonyl, or 3-oxa-8-azabicyclo[3.2.1]octan-8-ylcarbonyl), P 11  is hydrogen or C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), and M 11  is hydrogen. 
     In an embodiment, the present invention can be a cyclic peptide compound represented by formula (3) below that further specifies formula (1) above. 
     
       
         
         
             
             
         
       
     
     The definition of each group in formula (3) is the same as the definition of each group in formula (1). The cyclic peptide compound represented by formula (3) preferably has each of the following groups. 
     R 1  is hydrogen, P 1  is hydrogen or C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), and M 1  is hydrogen, and/or 
     R 2  is hydrogen or C 1 -C 6  alkyl (preferably C 3 -C 6  alkyl, and more preferably 1-methylpropyl), and P 2  is hydrogen or C 1 -C 6  alkyl (preferably hydrogen or C 1 -C 3  alkyl, and more preferably hydrogen or methyl), and/or 
     R 3  is hydrogen, P 3  is C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), and/or 
     R 4  is hydrogen, P 4  is C 1 -C 6  alkyl (preferably hydrogen or C 1 -C 3  alkyl, and more preferably methyl), and/or 
     R 5  is C 3 -C 8  cycloalkylC 1 -C 6  alkyl (preferably C 3 -C 6  cycloalkylC 1 -C 2  alkyl, and more preferably C 5 -C 6  cycloalkylmethyl), and P 5  is C 1 -C 2  alkyl (preferably methyl), and/or 
     R 6  is hydrogen, and P 6  is C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), and/or 
     R 7  is C 7 -C 14  aralkyl (preferably benzyl or phenethyl, and more preferably benzyl) optionally substituted with 1 to 5 (preferably 1 to 3) groups independently selected from the group consisting of halogen and C 1 -C 6  haloalkyl (preferably C 1 -C 3  fluoroalkyl, and more preferably trifluoromethyl), and P 7  is hydrogen, and Q 7  is hydrogen, and/or 
     R 8  and P 8 , together with the carbon atom to which R 8  is attached and the nitrogen atom to which P 8  is attached, form a 4- to 7-membered saturated heterocyclic ring (preferably an azetidine ring, a pyrrolidine ring, or a piperidine ring, and more preferably a pyrrolidine ring), and/or 
     R 9  and Q 9 , together with the carbon atom to which they are attached, form a 3- to 8-membered alicyclic ring (preferably a 3- to 6-membered alicyclic ring, and more preferably a cyclobutane ring or a cyclopentane ring), and P 9  is hydrogen, and/or 
     R 10  is C 3 -C 8  cycloalkyl (preferably C 3 -C 6  cycloalkyl, and more preferably cyclopentyl or cyclohexyl), and P 10  is C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl), and/or 
     R 11  is hydrogen, C 7 -C 14  aralkyl (preferably benzyl or phenethyl, and more preferably benzyl) optionally substituted with 1 to 5 (preferably 1 to 3) halogen atoms (preferably fluorine), or C 1 -C 6  alkoxyC 1 -C 6  alkyl (preferably C 2 -C 6  alkoxyC 1 -C 2  alkyl, and more preferably C 3 -C 5  alkoxymethyl) optionally substituted with one hydroxy group, and P 11  is C 1 -C 6  alkyl (preferably C 1 -C 3  alkyl, and more preferably methyl). 
     In an embodiment, the present invention can be a cyclic peptide compound represented by formula (4) below that further specifies formula (1) above. 
     
       
         
         
             
             
         
       
     
     R 1  to R 11 , P 1  to P 11 , Q 7 , and Q 9  in formula (4) are the same as R 1  to R 11 , P 1  to P 11 , Q 7 , and Q 9  in formula (2) above, respectively, and n and m are each independently 1 or 2. Moreover, —S— in formula (4) may be oxidized to be —S(O)— or —S(O) 2 —. 
     In an embodiment, the present invention can be a cyclic peptide compound represented by formula (5) below that further specifies formula (1) above. 
     
       
         
         
             
             
         
       
     
     R 1  to R 11 , P 1  to P 11 , Q 7 , and Q 9  in formula (5) are the same as R 1  to R 11 , P 1  to P 11 , Q 7 , and Q 9  in formula (2) above, respectively, and n and m are each independently 1 or 2. Moreover, —S— in formula (5) may be oxidized to be —S(O)— or —S(O) 2 —. 
     In an embodiment, the present invention can be formula (6) below wherein —CO-L 1 -in formula (1) above is replaced with —(CH 2 ) n C≡CCH 2 S(CH 2 ) m —, —(CH 2 ) n CH═CHCH 2 S(CH 2 ) m —, or —(CH 2 ) n+3 S(CH 2 ) m —, and L 11  is a single bond. 
     
       
         
         
             
             
         
       
     
     R 1  to R 11 , P 1  to P 11 , Q 7 , and Q 9  in formula (6) are the same as R 1  to R 11 , P 1  to P 1 , Q 7 , and Q 9  in formula (2) above, respectively, 
         
represents a single bond, a double bond, or a triple bond, n is 1, 2, or 3, and m is 1 or 2. Moreover, —S— in formula (6) may be oxidized to be —S(O)— or —S(O) 2 —.
 
     In an embodiment, the present invention can be formula (7) below wherein —CO-L 11 -in formula (1) is replaced with —(CH 2 ) n C≡CCH 2 S(CH 2 ) m —, —(CH 2 ) n CH═CHCH 2 S(CH 2 ) m —, or —(CH 2 ) n+3 S(CH 2 ) m —, and L 1  is a single bond. 
     
       
         
         
             
             
         
       
     
     R 1  to R 11 , P 1  to P 11 , Q 7 , and Q 9  in formula (7) are the same as R 1  to R 11 , P 1  to P 11 , Q 7 , and Q 9  in formula (2), respectively, 
         
represents a single bond, a double bond, or a triple bond, n is 1, 2, or 3, and m is 1 or 2. Moreover, —S— in formula (7) may be oxidized to be —S(O)— or —S(O) 2 —.
 
     In an embodiment, the present invention can be a cyclic peptide compound represented by formula (8) below. 
     
       
         
         
             
             
         
       
     
     R 2  to R 11 , P 2  to P 11 , Q 7 , and Q 9  in formula (8) are the same as R 2  to R 11 , P 2  to P 11 , Q 7 , and Q 9  in the above-mentioned formula (1), respectively, and n and m are each independently 1 or 2. Further, —S— in formula (8) may be oxidized to be —S(O)— or —S(O) 2 —. 
     Specific examples of the cyclic peptide compound of the present invention are as follows. The structural formulae of the following compounds (1) to (762), (764) to (845), (847) to (1027), (1029) to (1146), and (1148) to (2186) are shown in Table 24. That is, the numbers given to the following compounds correspond to the numbers given to the compounds shown in Table 24, respectively.
     (1) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9,18-bis(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2) (8S,11S,17S,26S,29S,33R,36S)-17-(cyclohexylmethyl)-11-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-8,29,36-triisobutyl-6,15,18,21,24,30,33,34-octamethyl-26-[(1S)-1-methylpropyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (3) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-8-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-29-isobutyl-36-isopropyl-9,15,18,21,24,30,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (4) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-19-isopropyl-N,N,3,4,10,14,17,22,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (5) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-33-ethyl-11-isobutyl-N,N,5,6,12,16,19,36-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (6) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-4,10,14,17,23,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-[[6-(trifluoromethyl)-3-pyridyl]methyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (7) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-8-(methoxymethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (8) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-(cyclopentylmethyl)-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (9) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (10) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-[[6-(trifluoromethyl)-3-pyridyl]methyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (11) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (12) allyl N-[4-[(3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-9-yl]butyl]carbamate,   (13) (3S,9S,12S,18S,27S,30S,34S)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-9-(2-phenylethyl)-34-(piperidine-1-carbonyl)-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (14) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopropyl-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (15) (8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(4-chlorobenzyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (16) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (17) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-8-(2-methoxyethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (18) (3S,9S,18S,21S,25R,28S,31S,34S)-31-benzyl-28-isobutyl-7,10,13,16,21,22,25,29,32-nonamethyl-9,18-bis[(1S)-1-methypropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (19) (3S,9S,12S,18S,27S,30S,34R)-12-[2-(4-chlorophenyl)ethyl]-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,6,6,10,16,19,22,25,30,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (20) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (21) (3S,6S,9S,12S,18S,27S,30S,34S)-6,9-dibenzyl-18-[(4-chlorophenyl)methyl]-12-[(3,5-difluorophenyl)methyl]-3-isopropyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (22) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopentyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (23) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-36-ethyl-11-isobutyl-18-isopropyl-5,6,12,16,19,33-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (24) (3S,6S,9S,13S,16S,19S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-19-isopropyl-N,N,3,4,10,14,17,22,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (25) (6S,12S,21S,24S,26aR,29aR,32S,35S,37aS)-35-benzyl-21-((S)-sec-butyl)-12-(4-chlorobenzyl)-32-isobutyl-10,13,16,19,24,25,33,36-octamethyl-6-(4-(trifluoromethyl)phenethyl)hexacosahydro-1H-cyclopenta[f1]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-5,8,11,14,17,20,23,26,31,34,37(37aH)-undecaone,   (26) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (27) (3S,6S,9S,13S,16S,22S,25,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-22-(isopentyloxymethyl)-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (28) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-12-[2-(4-fluorophenyl)ethyl]-3,9-diisobutyl-4,6,6,10,16,19,22,25,30,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (29) (3S,6S,9S,12S,18S,27S,30S,34S)-6,9-dibenzyl-2-[(3-chlorophenyl)methyl]-18-[(4-chlorophenyl)methyl]-16-ethyl-3-isopropyl-4,7,19,22,25,30,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (30) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-(cyclopentylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (31) (4R,7S,13S,16S,22S,31S,34S)-22-(cyclohexylmethyl)-7,13-diisobutyl-4,8,10,10,14,20,23,26,29-nonamethyl-31-[(1S)-1-methylpropyl]-16-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,5,8,11,14,17,20,23,26,29,32-undecazabicyclo[32.4.0]octatriacontane-2,6,9,12,15,18,21,24,27,30,33-undecone,   (32) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-35-(prop-2-yn-1-yl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (33) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,-(34) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclohexyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (35) (8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (36) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-(4-pyridylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (37) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-(cyclopentylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (38) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11,35-bis(cyclohexylmethyl)-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (39) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclohexyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (40) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (41) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(3,3-difluoroazetidin-1-yl)-2-oxo-ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-19-(propoxymethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (42) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(3-chlorobenzyl)-18-cyclopentyl-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (43) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[(2-fluorophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (44) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (45) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-8-(cyclobutoxymethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (46) (3S,6S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-3,6,9-triisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (47) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (48) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36,36-difluoro-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (49) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (50) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (51) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-9-isobutyl-3-isopropyl-4,7,10,16,19,22,25,30,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (52) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-(2-methylsulfonylethyl)-25-(piperidine-1-carbonyl)spiro[1l,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (53)N-tert-butyl-2-[[(3S,6S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,16,19,22,25,30,31-heptamethyl-27-1[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-6-yl]methoxy]acetamide,   (54) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-5,12,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)-11-pentyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (55) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-5,6,12,16,19,33-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (56) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-7,10,13,16,21,22,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-26-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (57) (6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-9,16,22-triisobutyl-4,10,13,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (58) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-cyclohexyl-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (59) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-(cyclobutylmethyl)-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (60) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-(cyclopentylmethyl)-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (61) (8S,11S,17S,26S,29S,33R,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-8,36-diisobutyl-9,15,18,21,24,29,30,33,37-nonamethyl-26-[(1S)-1-methylpropyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (62) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (63) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-(3-pyridylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (64) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11,15-diisobutyl-5,6,12,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (65) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (66) (3S,9S,18S,21S,25R,28S,34S,36R)-28-cyclopentyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (67) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,22,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (68) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-(cyclopropylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (69) (8S,11S,17S,26S,29S,33S,36S)-8-benzyl-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (70)N-(tert-butyl)-2-(((5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-5-yl)methoxy)acetamide,   (71) (3S,6S,10R,13S,16S,19S,22S,28S,34S)-16-benzyl-28-[(4-chlorophenyl)methyl]-19-isobutyl-13-isopropyl-6,7,10,14,17,20,26,29,32-nonamethyl-3-[(1S)-1-methylpropyl]-22-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,11,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,12,15,18,21,24,27,30,33-undecone,   (72) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (73) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (74) (3S,9S,18S,21S,25R,28S,34S,36R)-9-(cyclohexylmethyl)-28-cyclopentyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (75) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclobutylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (76) (6′S,15′S,18′S,22′R,25′S,30a′S,36′S,38a′R)-15′-((S)-sec-butyl)-36′-(3-chloro-4-(trifluoromethyl)phenethyl)-6′-(cyclohexylmethyl)-18′-isobutyl-25′-isopropyl-7′,10′,13′,19′,22′,26′-hexamethyltetracosahydro-5′H-spiro[cyclopentane-1,28′-dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,24′,27′,30′,35′,38′(21′H,29′H)-undecaone,   (77) (8S,11S,15R,18S,23aS,29S,31aR,37S,39aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-37-(cyclohexylmethyl)-18-isopropyl-6,11,12,15,19,38-hexamethyltetracosahydro-2H,4H-spiro[azeto[2,1-u]dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,36,39(14H,22H)-undecaone,   (78) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(5,5-difluoropentyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (79) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-cyclopentyl-11-isobutyl-5,6,12,15,16,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (80) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-11-((R)-1-methoxyethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (81) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-8-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclohexane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (82) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(2-chlorobenzyl)-19′-cyclopentyl-7′,12′,13′,16′,20′,34′,37′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (83) (3S,9S,12S,18S,27S,30S,34R)-3-butyl-18-[(4-chlorophenyl)methyl]-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-9,30-diisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (84) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-8-(cyclopentylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (85) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (86) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-((2-hydroxy-2-methylpropoxy)methyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (87) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-bis(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (88) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-8-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (89) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-11-(but-3-yn-1-yl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(4-iodobenzyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (90) (3S,9S,18S,21S,25S,28S,34S,36S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-36-phenyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (91) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-((R)-1-hydroxyethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (92) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-18-(5,5-difluoropentyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (93) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,22,25,29,31,31,32-undecamethyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (94) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-(5,5-difluoropentyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (95) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[(3-fluorophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (96) (3S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-6,6,7,16,19,22,25,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (97) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-8-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-29-isobutyl-36-isopropyl-N,N,9,15,18,21,24,30,37-nonamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-33-carboxamide,   (98) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-35-isobutyl-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (99) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (100) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-cyclopropyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (101) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-18-cyclopropyl-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (102) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-19-isopropyl-N,N,3,4,10,14,17,22,23,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (103) (2aS,5S,11S,14S,20S,23S,30aS,33S,36S)-33-((S)-sec-butyl)-14-butyl-11-(3-chloro-4-(trifluoromethyl)phenethyl)-5-(4-chlorobenzyl)-20-isobutyl-4,7,16,17,17,22,35,36-octamethyl-23-(piperidine-1-carbonyl)tetracosahydroazeto[1,2-j]pyrido[1,2-a][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-3,6,9,12,15,18,21,25,31,34,37(1H,22H,27H)-undecaone,   (104) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(3,3-difluoroazetidin-1-yl)ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-19-(2,2,2-trifluoroethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (105) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-I[(1S)-1-methylpropyl]-13-(morpholine-4-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (106) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclohexyl-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (107) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (108) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (109) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-9-isopropyl-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (110) (3S,9S,18S,21S,25R,28S,34S)-21-but-3-ynyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-[(4-iodophenyl)methyl]-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (111) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-6-[[2-(trifluoromethoxy)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (112) (5S,8S,12S,15S,20aS,26S,32S,37aS)-5-((S)-sec-butyl)-26-(4-chlorophenethyl)-32-(cyclohexylmethyl)-8-isobutyl-15-isopropyl-9,13,16,30,33,36-hexamethyl-12-(piperidine-1-carbonyl)docosahydrospiro[azeto[1,2-g]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-18,1′-cyclopentan]-4,7,10,14,17,20,25,28,31,34,37(2H,11H,19H)-undecaone,   (113) (8S,11S,17S,26S,29S,33R,36S)-17-[(4-chlorophenyl)methyl]-8,33,36-triisobutyl-29-isopropyl-9,15,18,21,24,30,37-heptamethyl-26-[(1S)-1-methylpropyl]-11-[2-[4-(trifluoromethyl)phenyl]ethyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (114) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-22-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (115) (8S,11S,15S,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-6,11,12,16,19,32,33,36-octamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (116) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,22,25,29-hexamethyl-8-[(1S)-1-methylpropyl]-16-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (117) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-5,6,11,12,15,19,32,33,36-nonamethyl-35-(3-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (118) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-8-[(1R)-1-hydroxyethyl]-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (119) (3S,9S,12S,18S,27S,30S,34R)-18-(cyclohexylmethyl)-12-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-4,6,6,10,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (120) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(4-chlorobenzyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (121) (3S,9S,18S,21S,25R,28S,34S)-9-[(4-chlorophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (122) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (123) (3S,9S,18S,21S,25R,28S,34S)-16-butyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (124) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-9,30-diisobutyl-3-isopropyl-4,7,10,16,19,22,25,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (125) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-9-butyl-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-18-[(4-methoxyphenyl)methyl]-1,6,7,16,19,22,25,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (126) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(propoxymethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (127) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-cyclobutyl-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (128) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,12,16,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (129) (3S,6S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(3,3-difluoroazetidin-1-yl)-2-oxo-ethyl]-3-isopropyl-1,4,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-6-(propoxymethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (130) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(3,3-difluoroazetidin-1-yl)ethyl]-9-isobutyl-19-(methoxymethyl)-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (131) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-22-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (132) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (133) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (134) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18,35-dicyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (135) (6&#39;S,15&#39;S,18&#39;S,22&#39;S,25&#39;S,30a&#39;S,36&#39;S,38a′R)-15′-((S)-sec-butyl)-36′-(3-chloro-4-(trifluoromethyl)phenethyl)-6′-(cyclohexylmethyl)-25′-isopropyl-7′,10′,13′,18′,19′,23′,26′-heptamethyl-22′-(piperidine-1-carbonyl)tetracosahydro-5′H-spiro[cyclopentane-1,28′-dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,24′,27′,30′,35′,38′(21′H,29′H)-undecaone,   (136) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-(cyclopropylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (137) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-22-ethyl-21-isobutyl-7,10,13,16,26,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (138) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-36-ethyl-25,25-difluoro-11-isobutyl-5,12,15,16,19,33-hexamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (139) (5S,8S,12S,15S,20aS,26S,32S,37aS)-5-((S)-sec-butyl)-32-(cyclohexylmethyl)-26-(3-fluoro-4-(trifluoromethyl)phenethyl)-8-isobutyl-15-isopropyl-9,13,16,30,33,36-hexamethyl-12-(piperidine-1-carbonyl)docosahydrospiro[azeto[1,2-g]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-18,1′-cyclopentan]-4,7,10,14,17,20,25,28,31,34,37(2H,11H,19H)-undecaone,   (140) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-9-(propoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (141) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-(2-methoxyethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (142) (6&#39;S,12&#39;S,21&#39;S,24&#39;S,27a′R,34&#39;S,39a&#39;S)-21′-((S)-sec-butyl)-12′-(cyclohexylmethyl)-6′-(3-fluoro-4-(trifluoromethyl)phenethyl)-24′-isobutyl-34′-isopropyl-10′,13′,16′,19′,25′,35′-hexamethylhexacosahydrospiro[cyclopentane-1,37′-pyrido[1,2-e1]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,23′,26′,33′,36′,39′(38′H)-undecaone,   (143) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-6-[[3-(trifluoromethoxy)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (144) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-5,6,12,16,19,33,36-heptamethyl-11-pentyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (145) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-8-(5,5-difluoropentyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (146) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-cyclopentyl-36′-(4-fluorobenzyl)-7′,12′,13′,16′,20′,34′,37′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (147) (8S,11S,15S,18S,23aS,25S,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(cyclohexylmethyl)-11-isobutyl-6,12,16,19,33,36-hexamethyl-25-phenyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (148) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-18-(methoxymethyl)-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (149) (3S,9S,18S,21S,25R,28S,31S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-31-ethyl-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29,31-octamethyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (150) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (151) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-cyclopentyl-7′,12′,13′,16′,20′,34′,37′-heptamethyl-36′-(4-methylbenzyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (152) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-9-isobutyl-3-isopropyl-4,7,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (153) (3S,9S,12S,18S,27S,30S,34R)-12-[2-(3-chlorophenyl)ethyl]-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,6,6,10,16,19,22,25,30,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (154) (3S,6S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(3,3-difluoroazetidin-1-yl)ethyl]-3-isopropyl-1,4,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-6-(propoxymethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (155) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-5,12,16,19,33,36-hexamethyl-11-pentyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (156) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-29-isobutyl-36-isopropyl-8,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (157) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-8-cyclobutyl-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (158) (6S,9S,13R,16S,22S,25S,31S,34S)-31-[(4-chlorophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16,22-diisobutyl-9-isopropyl-4,10,13,17,23,29,32-heptamethyl-6-[(1S)-1-methylpropyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (159) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-9-(2-methoxyethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (160) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-ethyl-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (161) (3S,9S,18S,21S,25S,28S,34S)-21-but-3-ynyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-[(4-iodophenyl)methyl]-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (162) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-28-(2-methylsulfonylethyl)-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (163) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-5,12,16,19,33,36-hexamethyl-11-pentyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (164) (3S,9S,18S,21S,25S,28S,34S)-18-allyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (165) (3S,9S,12S,18S,27S,30S,34R)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (166) (3S,9S,12S,18S,27S,30S,34S)-18-(cyclohexylmethyl)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-9-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (167) (3S,9S,18S,21S,25S,28S,34S)-3-[2-(4-chlorophenyl)ethyl]-9-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (168) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-6-[(2-chlorophenyl)methyl]-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (169) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-31-(cyclohexylmethyl)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-22-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (170) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-1,6,6,16,19,22,25,30,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (171) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-8-[(3,4-difluorophenyl)methyl]-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (172) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-(cyclopropylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (173) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-21-(2,2,2-trifluoroethyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (174) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-8-(2-(methylsulfonyl)ethyl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (175) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-35-(2-methoxyethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (176) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (177) (8S,11S,17S,26S,29S,33S,36S)-11-[2-(4-chlorophenyl)ethyl]-17-(cyclohexylmethyl)-8-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-29-isobutyl-36-isopropyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (178) (6S,9S,13R,16S,22S,25S,31S,34S)-31-(cyclohexylmethyl)-25-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-9,16,22-triisobutyl-4,10,13,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (179) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[(3-chlorophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (180) 3-((5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxo-15-(piperidine-1-carbonyl)tetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-5-yl)-N-methylpropanamide,   (181) (5S,8S,12R,15S,20aS,26S,32S,34aS,38aS)-5-((S)-sec-butyl)-26-(3-chloro-4-(trifluoromethyl)phenethyl)-32-(cyclohexylmethyl)-8-isobutyl-15-isopropyl-9,12,16,30,33-pentamethyldocosahydro-25H-spiro[bis(azeto)[1,2-g:1′,2′-j]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-18,1′-cyclopentan]-4,7,10,14,17,20,25,28,31,34,38(2H,11H,19H,34aH)-undecaone,   (182) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (183) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclobutyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (184) (3S,6S,9S,12S,18S,27S,30S,34S)-6,9-dibenzyl-8-[(4-chlorophenyl)methyl]-12-[(3-fluorophenyl)methyl]-3-isopropyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (185) (6&#39;S,9&#39;S,13′R,16&#39;S,21a&#39;S,27&#39;S,33&#39;S,38a&#39;S)-6′-((S)-sec-butyl)-27′-(3-chloro-4-(trifluoromethyl)phenethyl)-33′-(cyclohexylmethyl)-9′-isobutyl-16′-isopropyl-10′,13′,17′,31′,34′,37′-hexamethyldocosahydro-1′H-spiro[cyclopentane-1,19′-dipyrrolo[1,2-g:1′,2′-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,15′,18′,21′,26′,29′,32′,35′,38′(12′H,20′H,38a′H)-undecaone,   (186) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(3-chlorobenzyl)-19′-cyclopentyl-7′,12′,13′,16′,20′,34′,37′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (187) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (188) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-22-[(4-methoxyphenyl)methyl]-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (189) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-30-isopropyl-4,10,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,4,7,10,13,16,19,22,25,28,31-undecazabicyclo[32.4.0]octatriacontane-6,1′-cyclopentane]-2,5,8,11,14,17,20,23,26,29,32-undecone,   (190) (3S,6S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(3,3-difluoroazetidin-1-yl)-2-oxo-ethyl]-6-isobutyl-3-isopropyl-1,4,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (191) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,22,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (192) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-8-(m-tolylmethyl)-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (193) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-18-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxo-8-(pentan-3-yl)hexatriacontahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-15-carboxamide,   (194) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-cyclopentyl-36′-(3-fluorobenzyl)-7′,12′,13′,16′,20′,34′,37′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (195) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclopropylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (196) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-22-ethyl-28-isopropyl-7,10,13,16,21,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (197) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopropyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (198) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-28-cyclopentyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (199) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (200) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-8-(cyclopropylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (201) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (202) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-12-[(3-chloro-5-fluoro-phenyl)methyl]-18-[(4-chlorophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (203) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclohexyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-25,25-difluoro-11-isobutyl-5,12,15,16,19,33-hexamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (204) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-7-cyclopropyl-21-isobutyl-28-isopropyl-10,13,16,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (205) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-8,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (206) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-9-I[(4-fluorophenyl)methyl]-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (207) (8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(4-chlorobenzyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (208) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-28-(2,2,2-trifluoroethoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (209) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-5,12,16,19,33,36-hexamethyl-11-pentyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (210) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-16-ethyl-21-isobutyl-28-isopropyl-7,10,13,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (211) (8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (212) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclobutylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (213) (4R,7S,13S,16S,22S,31S,34S)-16-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-(cyclohexylmethyl)-7,13-diisobutyl-4,8,14,20,23,26,29-heptamethyl-31-[(1S)-1-methylpropyl]spiro[1,5,8,11,14,17,20,23,26,29,32-undecazabicyclo[32.4.0]octatriacontane-10,1′-cyclopentane]-2,6,9,12,15,18,21,24,27,30,33-undecone,   (214) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-1,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (215) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-22-butyl-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxohexatriacontahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-15-carboxamide,   (216) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[(2-chlorophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (217) (8S,11S,17S,26S,29S,33R,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-8,29,36-triisobutyl-9,15,18,21,24,30,33,37-octamethyl-26-[(1S)-1-methylpropyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (218) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-8-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-29-isobutyl-36-isopropyl-N,N,9,15,18,21,24,30,34,37-decamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-33-carboxamide,   (219) (3S,9S,12S,18S,27S,30S,34R)-18-(cyclohexylmethyl)-3,9-diisobutyl-4,6,6,10,16,19,22,25,30,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (220) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (221) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-cyclobutyl-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (222) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(3,3-difluoroazetidin-1-yl)-2-oxo-ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-19-(2,2,2-trifluoroethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (223) (3S,9S,18S,21S,25R,28S,31R,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-31-ethyl-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29,31-nonamethyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (224) (3S,6S,9S,12S,18S,27S,30S,34S)-6,9-dibenzyl-2-[(3-chlorophenyl)methyl]-18-[(4-chlorophenyl)methyl]-25-ethyl-3-isopropyl-4,7,16,19,22,30,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (225) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-cyclopentyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (226) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclobutoxymethyl)-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (227) (6&#39;S,12&#39;S,21&#39;S,23a&#39;S,31′R,34&#39;S,39a&#39;S)-21′-((S)-sec-butyl)-12′-(4-chlorobenzyl)-34′-isobutyl-10′,13′,16′,19′,31′,35′-hexamethyl-6′-(4-(trifluoromethyl)phenethyl)tetracosahydrospiro[cyclopentane-1,37′-pyrido[1,2-a]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,23′,29′,33′,36′,39′(23a′H,30′H,38′H)-undecaone,   (228) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-((R)-1-hydroxyethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (229) (3S,9S,18S,21S,25S,28S,34S)-9-[(4-chlorophenyl)methyl]-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (230) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-(cyclobutylmethyl)-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (231) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclohexane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (232) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,7,16,19,22,25,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (233) 2-[[(3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-3-isobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-9-yl]methoxy]-N-tert-butyl-acetamide,   (234) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopropylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (235) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-35-(2-(methylsulfonyl)ethyl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (236) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (237) (3S,9S,18S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-25-[(3-fluorophenyl)methyl]-7,10,13,16,26,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,23,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,24,27,30,33-undecone,   (238) 3-[[(3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-9-yl]methyl]benzonitrile,   (239) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (240) (3S,6S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-6-ethyl-30-isobutyl-3-isopropyl-1,4,10,16,19,22,25,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (241) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (242) (3S,9S,18S,21S,25R,28S,31S,34S)-31-allyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29,31-octamethyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (243) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-(3-pyridylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (244) (3S,9S,18S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-25-[(2-hydroxy-2-methyl-propoxy)methyl]-7,10,13,16,23,26,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,23,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,24,27,30,33-undecone,   (245) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (246) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-7,10,13,16,21,22,26,29-octamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (247) (3S,9S,12S,18S,27S,30S,34S)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-9-[(4-methoxyphenyl)methyl]-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (248) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-(cyclopropylmethyl)-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (249) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (250) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-22-(isopentyloxymethyl)-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (251) (7S,10S,16S,25S,28S,32S,35S)-10-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-(cyclohexylmethyl)-7-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-28-isobutyl-35-isopropyl-8,14,17,20,23,29,33,36-octamethyl-25-[(1S)-1-methylpropyl]-32-(piperidine-1-carbonyl)-5,8,11,14,17,20,23,26,29,33,36-undecazaspiro[3.33]heptatriacontane-6,9,12,15,18,21,24,27,30,34,37-undecone,   (252) 3-[[(3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-12-yl]methyl]benzonitrile,   (253) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(4-chlorobenzyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (254) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-35-((2,2,2-trifluoroethoxy)methyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (255) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,26&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-cyclohexyl-36′-(cyclohexylmethyl)-12′-isobutyl-7′,13′,17′,20′,34′,37′-hexamethyl-26′-phenyl-16′-(piperidine-1-carbonyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (256) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (257) (3S,9S,12S,18S,27S,30S,34R)-9-butyl-18-[(4-chlorophenyl)methyl]-19-ethyl-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,30-diisobutyl-1,6,6,7,16,22,25,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (258) (3S,9S,18S,21S,25R,28S,34S)-9-[(4-chlorophenyl)methyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (259) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-6-[(2-methoxyphenyl)methyl]-1,7,16,19,22,25,31-heptamethyl-27-I[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (260) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-((R)-1-hydroxyethyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (261) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-3,9,30-triisobutyl-4,6,6,10,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (262) (3S,9S,12S,18S,27S,30S,34R)-18-(cyclohexylmethyl)-3,9,30-triisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (263) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-5,12,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)-11-pentyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (264) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-22-ethyl-28-isopropyl-7,10,13,16,21,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (265) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-3-(2-phenylethyl)-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (266) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-28-isopropyl-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (267) (8S,11S,15R,18S,23aS,29S,31aR,38S,40aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-38-(cyclohexylmethyl)-18-isopropyl-6,11,12,15,19,39-hexamethyltetracosahydro-2H,4H,28H-spiro[azeto[2,1-u]pyrido[2,1-o]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,37,40(14H,22H,31aH)-undecaone,   (268) (31S,21S,2R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopropane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (269) (31S,21S,25R,28S,34S)-28-cyclopentyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (270) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-cyclobutyl-35-(cyclohexylmethyl)-18-cyclopentyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (271) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (272) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (273) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-prop-2-ynyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (274) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,22,23,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (275) (3S,9S,18S,21S,25R,28S,31R,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-31-ethyl-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29,31-octamethyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (276) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (277) (8R,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-8,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (278) 2-((5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxo-15-(piperidine-1-carbonyl)tetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-8-yl)acetonitrile,   (279) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-36-ethyl-11-isobutyl-N,N,5,6,12,16,19,33-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (280) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-8-cyclopropyl-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (281) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (282) (8S,11S,17S,26S,29S,33S,36S)-8-[(3-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (283) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-(2-methylsulfonylethyl)-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (284) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-28-prop-2-ynyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (285) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9,21-bis(cyclohexylmethyl)-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (286) (4R,7S,13S,16S,22S,31S,34S)-22-[(4-chlorophenyl)methyl]-7,13-diisobutyl-4,8,10,10,14,20,23,26,29-nonamethyl-31-[(1S)-1-methylpropyl]-16-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,5,8,11,14,17,20,23,26,29,32-undecazabicyclo[32.4.0]octatriacontane-2,6,9,12,15,18,21,24,27,30,33-undecone,   (287) (3S,9S,18S,21S,25S,28S,31R,34S)-31-allyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29,31-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (288) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,22,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (289) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxo-35-(propoxymethyl)tetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (290) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclobutylmethyl)-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (291) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(cyclohexylmethyl)-5,6,11,12,15,19,21,21,22,33,36-undecamethyltetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (292) (3S,9S,18S,21S,25S,28S,34S)-3-[2-(4-chlorophenyl)ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (293) (5S,8S,11S,15S,18S,23aS,29S,31aR,37S,39aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-37-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,16,19,38-heptamethyl-15-(piperidine-1-carbonyl)tetracosahydro-2H,4H-spiro[azeto[2,1-u]dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,36,39(14H,22H)-undecaone,   (294) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-8,9,15,18,21,24,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (295) (3S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,9,30-triisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-I[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (296) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (297) (6&#39;S,9&#39;S,13&#39;S,16&#39;S,25&#39;S,31&#39;S,33a&#39;S,37a&#39;S,38a&#39;S)-16′-((S)-sec-butyl)-31′-(3-chloro-4-(trifluoromethyl)phenethyl)-6′-cyclohexyl-25′-(cyclohexylmethyl)-13′-isobutyl-5′,8′,12′,18′,21′,24′,27′-heptamethyl-9′-(piperidine-1-carbonyl)hexacosahydro-4′H-spiro[cyclopentane-1,3′-[1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontino[10,9-a]indol]-1′,4′,7′,11′,14′,17′,20′,23′,26′,29′,32′(2′H,8′H)-undecaone,   (298) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (299) (3S,9S,18S,21S,25R,28S,31S,34S)-31-benzyl-9-[(4-chlorophenyl)methyl]-28-isobutyl-7,10,13,16,21,22,25,29,32-nonamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.4.0]octatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (300) (3S,9S,18S,21S,25R,28S,34S)-21-but-3-ynyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-[(4-iodophenyl)methyl]-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (301) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (302) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (303) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isopentyl-N,N,5,12,16,19,33,36-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (304) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-8-((2,2,2-trifluoroethoxy)methyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (305) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-16,28-diisopropyl-7,10,13,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (306) allyl 3-[(3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-3-isobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-9-yl]propanoate,   (307) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,30&#39;S,33′R,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(cyclohexylmethyl)-19′-isopropyl-7′,12′,13′,17′,20′,33′,34′,37′-octamethyl-16′-(piperidine-1-carbonyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (308) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isopentyl-N,N,5,12,16,19,33,36-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (309) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclobutoxymethyl)-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (310) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-35-(3,4-difluorobenzyl)-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (311) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18,28-bis[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (312) (3S,9S,12S,18S,27S,30S,34S)-18-(cyclohexylmethyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (313) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-35-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (314) (5S,8S,11S,15S,18S,21S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-N,N,5,6,12,16,19,21,33,36-decamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxohexatriacontahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-15-carboxamide,   (315) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-3,9,30-triisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (316) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxo-35-(propoxymethyl)tetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (317) (8S,11S,17S,26S,29S,33S,36S)-8-[(2-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-isopropyl-N,N,9,15,18,21,24,29,30,34,37-undecamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-33-carboxamide,   (318) (5S,8S,12S,15S,20aS,26S,32S,34aS,38aS)-5-((S)-sec-butyl)-26-(3-chloro-4-(trifluoromethyl)phenethyl)-32-(cyclohexylmethyl)-8-isobutyl-15-isopropyl-9,13,16,30,33-pentamethyl-12-(piperidine-1-carbonyl)docosahydro-25H-spiro[bis(azeto)[1,2-g:1′,2′-j]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-18,1′-cyclopentan]-4,7,10,14,17,20,25,28,31,34,38(2H,11H,19H,34aH)-undecaone,   (319) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (320) (3S,9S,12S,18S,27S,30S,34S)-18-(cyclohexylmethyl)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-9-[(4-methoxyphenyl)methyl]-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (321) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9,21-bis(cyclohexylmethyl)-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (322) (3S,9S,18S,21S,25R,28S,31S,34S,36R)-31-benzyl-9-[(4-chlorophenyl)methyl]-36-ethoxy-28-isobutyl-7,10,13,16,21,22,25,29,32-nonamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (323) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-1,6,6,7,16,19,22,25,30,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (324) (10&#39;S,13&#39;S,17&#39;S,20&#39;S,25a&#39;S,31&#39;S,37&#39;S,39a&#39;S)-10′-((S)-sec-butyl)-37′-(cyclohexylmethyl)-31′-(3,4-dichlorophenethyl)-13′-isobutyl-20′-isopropyl-8′,14′,18′,21′,35′,38′-hexamethyl-17′-(piperidine-1-carbonyl)tetracosahydro-2′H,6′H-spiro[cyclopentane-1,23′-pyrido[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-6′,9′,12′,15′,19′,22′,25′,30′,33′,36′,39′(16′H,24′H)-undecaone,   (325) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopropylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (326) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopentylmethyl)-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (327) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-9-(cyclopentylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (328) (3S,9S,18S,21S,25S,28S,34S)-9-[(4-chlorophenyl)methyl]-10-ethyl-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,13,16,22,26,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (329) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-16-(2-ethoxyethyl)-21-isobutyl-28-isopropyl-7,10,13,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (330) (3S,9S,12S,18S,27S,30S,34S)-9-[(4-chlorophenyl)methyl]-18-(cyclohexylmethyl)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (331) (3S,6S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(3,3-difluoroazetidin-1-yl)ethyl]-6-isobutyl-3-isopropyl-1,4,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32   (332) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-9,27-bis[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (333) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-18-cyclopentyl-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (334) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (335) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-22-(o-tolylmethyl)-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (336) (3S,9S,12S,18S,27S,30S,34S)-18-(cyclohexylmethyl)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-9-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (337) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (338) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-22-[(5-methyl-3-pyridyl)methyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (339) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (340) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-22,31-bis(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (341) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,15,16,19,21,21,22,33,36-dodecamethyltetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (342) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-N,N,5,12,16,19,33,36-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxo-11-pentyltetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (343) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)-11-pentyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (344) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (345) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-36-ethyl-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (346) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-(p-tolylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (347) (6&#39;S,12&#39;S,21&#39;S,24&#39;S,26a′R,29a′R,32&#39;S,37a&#39;S)-21′-((S)-sec-butyl)-6′-(3-chloro-4-(trifluoromethyl)phenethyl)-12′-(cyclohexylmethyl)-24′-isobutyl-32′-isopropyl-10′,13′,16′,19′,25′,33′-hexamethylhexacosahydrospiro[cyclopentane-1,35′-cyclopenta[f1]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,23′,26′,31′,34′,37′(36′H)-undecaone,   (348) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (349) (5S,8S,11S,15S,18S,23aS,29S,31aR,38S,40aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-38-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,16,19,39-heptamethyl-15-(piperidine-1-carbonyl)tetracosahydro-2H,4H,28H-spiro[azeto[2,1-u]pyrido[2,1-o]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,37,40(14H,22H,31aH)-undecaone,   (350) (8S,11S,17S,26S,29S,33R,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-8-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-29-isobutyl-36-isopropyl-9,15,18,21,24,30,33,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (351) (3S,6S,9S,12S,18S,27S,30S)-6-benzyl-18-[(4-chlorophenyl)methyl]-9-isobutyl-3-isopropyl-4,7,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (352) (2aS,5S,11S,14S,20S,23S,30aS,33S)-33-((S)-sec-butyl)-14-butyl-11-(3-chloro-4-(trifluoromethyl)phenethyl)-5-(4-chlorobenzyl)-20-isobutyl-4,7,16,17,17,22,35-heptamethyl-23-(piperidine-1-carbonyl)tetracosahydroazeto[1,2-j]pyrido[1,2-a][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-3,6,9,12,15,18,21,25,31,34,37(1H,22H,27H)-undecaone,   (353) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (354) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,19,21,21,33,36-nonamethyl-35-(4-methylbenzyl)tetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (355) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-19-isopropyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-22-(thiazol-4-ylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (356) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,26,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (357) 2-[[(3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-I[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-9-yl]methyl]benzonitrile,   (358) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-8-(cyclopropylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (359) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (360) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (361) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-6,7,9,10,13,16,21,22,25,29-decamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (362) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (363) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-N,N,5,12,16,19,33,36-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (364) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (365) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclohexyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (366) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (367) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopentylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (368) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (369) (3S,9S,18S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-7,10,13,16,23,26,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,23,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,24,27,30,33-undecone,   (370) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (371) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (372) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-7,16,19,22,25,30,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (373) 3-[[(3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-12-yl]methyl]benzonitrile,   (374) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (375) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (376) (3S,9S,12S,18S,27S,30S,34S)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-18-(p-tolylmethyl)-9-[[3-(trifluoromethyl)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (377) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclohexyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (378) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,22,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (379) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[2-(3,3-difluoro-1-piperidyl)ethyl]-9-isobutyl-19-isopropyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (380) (3S,6R,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-isopropyl-6,7,10,13,16,21,22,26,29-nonamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (381) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (382) (3S,6S,9S,13S,16S,19S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,19,22,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (383) (3S,9S,18S,21S,25R,28S,31S,34S)-9-[(4-chlorophenyl)methyl]-31-(cyclohexylmethyl)-28-isobutyl-7,10,13,16,21,22,25,29,32-nonamethyl-8-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (384) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-22-(thiazol-4-ylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (385) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-fluorophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (386) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18,35-dicyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (387) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-11-((2,2,2-trifluoroethoxy)methyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (388) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-35-(4-fluorobenzyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (389) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(3,3-difluoro-1-piperidyl)ethyl]-9-isobutyl-19-isopropyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (390) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (391) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-11-propyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (392) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-4,10,14,17,23,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-propyl-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (393) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-cyclopentyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (394) (5S,8S,11S,15S,18S,21S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-21-ethyl-11-isobutyl-18-isopropyl-5,6,12,16,19,21,33,36-octamethyl-15-(piperidine-1-carbonyl)tetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (395) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-7-ethyl-21-isobutyl-28-isopropyl-10,13,16,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (396) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-5,6,11,12,15,19,32,33,35,36-decamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (397) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-11-(2-methoxyethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (398) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-12-[2-(p-tolyl)ethyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (399) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-8-cyclopentyl-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (400) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-(cyclopentylmethyl)-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (401) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-25-ethoxy-36-ethyl-11-isobutyl-5,12,15,16,19,33-hexamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (402) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (403) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (404) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (405) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,16,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]-13-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (406) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-1,4,7,16,19,22,25,30,34-nonamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,11,14,17,20,23,26,29,32-undecone,   (407) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,4′-tetrahydropyran]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (408) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8,18-di((S)-sec-butyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (409) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-35-(cyclohexylmethyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (410) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (411) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-cyclobutyl-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (412) (6&#39;S,15&#39;S,18&#39;S,22′R,25&#39;S,30a&#39;S,36&#39;S,38a′R)-15′-((S)-sec-butyl)-36′-(3-chloro-4-(trifluoromethyl)phenethyl)-6′-(cyclohexylmethyl)-25′-isopropyl-7′,10′,13′,18′,19′,22′,26′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,28′-dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,24′,27′,30′,35′,38′(21′H,29′H)-undecaone,   (413) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-9-ethyl-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (414) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (415) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (416) (7S,10S,14R,17S,22aS,28S,34S,36aS,40aS)-7-((S)-sec-butyl)-28-(3-chloro-4-(trifluoromethyl)phenethyl)-34-(cyclohexylmethyl)-10-isobutyl-17-isopropyl-11,14,18,32,35-pentamethyltetracosahydro-27H-spiro[azeto[1,2-j]pyrido[1,2-g]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-20,1′-cyclopentan]-6,9,12,16,19,22,27,30,33,36,40(2H,13H,21H,36aH)-undecaone,   (417) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (418) (6S,9S,13R,16S,22S,25S,31S,34S)-31-[(4-chlorophenyl)methyl]-25-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-16,22-diisobutyl-9-isopropyl-4,10,13,17,23,29,32-heptamethyl-6-[(1S)-1-methylpropyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (419) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-11-(2-(methylsulfonyl)ethyl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (420) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-8-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (421) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-18-(cyclopropylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[11,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (422) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (423) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-19-ethyl-2-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,22,25,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (424) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (425) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-(5,5-difluoropentyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (426) (3S,9S,12S,18S,27S,30S,34S)-9-[(2-chlorophenyl)methyl]-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-3-isopropyl-1,4,6,6,10,16,19,22,25,30,31-undecamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (427) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-[(1R)-1-hydroxyethyl]-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (428) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-36-phenyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (429) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-cyclopentyl-36′-isobutyl-7′,12′,13′,16′,20′,34′,37′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (430) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclohexyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (431) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(3,5-dichlorophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (432) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (433) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-4,9,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-(3-pyridylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (434) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-9-(cyclopentylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (435) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5-((isopentyloxy)methyl)-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (436) (3S,9S,12S,18S,27S,30S,34R)-25-butyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,6,6,10,16,19,22,30,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (437) (31S,1S,25S,28S,34S)-25-(azetidine-1-carbonyl)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-I[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (438) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (439) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclohexane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (440) 2-[(3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-18-yl]acetonitrile,   (441) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-(thiazol-4-ylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (442) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-22-(2-phenylethyl)-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (443) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-6-ethyl-11-isobutyl-18-isopropyl-5,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (444) (3S,6S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-30-isobutyl-3-isopropyl-1,4,6,10,16,19,22,25,31-nonamethyl-27-[(1 S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (445) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-9-(propoxymethyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (446) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-cyclobutyl-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (447) (8S,11S,15S,18S,23aS,29S,31aR,37S,39aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-37-(cyclohexylmethyl)-18-isopropyl-6,11,12,16,19,38-hexamethyl-15-(piperidine-1-carbonyl)tetracosahydro-2H,4H-spiro[azeto[2,1-u]dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,36,39(14H,22H)-undecaone,   (448) (3S,9S,18S,21S,25S,28S,34S)-3-[2-(4-chlorophenyl)ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,4′-tetrahydropyran]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (449) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-22-(m-tolylmethyl)-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (450) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-8-((R)-1-hydroxyethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (451) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclobutylmethyl)-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (452) (8S,11S,17S,26S,29S,33R,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-8-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-29-isobutyl-36-isopropyl-9,15,18,21,24,30,33,37-octamethyl-26-[(1S)-1-methylpropyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (453) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,19,33,36-hexamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (454) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,25,26,29,31,31,32-dodecamethyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (455) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-(cyclobutylmethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (456) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclohexyl-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-8-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (457) (3S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-9-ethyl-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (458) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,16,19,33,36-octamethyl-15-(piperidine-1-carbonyl)-29-(4-(trifluoromethyl)phenethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (459) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-22-[(2-methoxyphenyl)methyl]-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (460) (31S,21S,2S,2S,34S,36S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-36-(4,4-difluoro-1-piperidyl)-28-isopropyl-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (461) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-9-(cyclopentylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (462) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (463) (3S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-30-isobutyl-3-isopropyl-1,4,6,6,10,16,19,22,25,31-decamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (464) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(2-chlorobenzyl)-18-cyclopentyl-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (465) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-cyclobutyl-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (466) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (467) (3S,6S,9S,12S,18S,27S,30S,34S)-6,9-dibenzyl-18-[(4-chlorophenyl)methyl]-3-isopropyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-12-(m-tolylmethyl)-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (468) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopropane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (469) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (470) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-35-((isopentyloxy)methyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (471) (3S,9S,12S,18S,27S,30S,34R)-9-benzyl-18-[(4-chlorophenyl)methyl]-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (472) (6S,9S,13S,16S,19S,22S,25S,31S,34S)-19-benzyl-22-butyl-31-(cyclohexylmethyl)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,20,29,32-hexamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (473) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-12-[[3-(trifluoromethoxy)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (474) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-8-(cyclopropylmethyl)-11-isobutyl-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (475) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclohexyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (476) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (477) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-4,10,14,17,23,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-22-[(5-methyl-3-pyridyl)methyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (478) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-4,10,14,17,23,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-propyl-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (479) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-[[6-(trifluoromethyl)-3-pyridyl]methyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (480) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-4,10,14,17,23,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-(4-pyridylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (481) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (482) (3S,6R,9S,18S,21S,25R,28S,34S)-9-benzyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (483) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-6-[(3-fluorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-1[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (484) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-(methoxymethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (485) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-8-((isopentyloxy)methyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (486) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclohexyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (487) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-35-(methoxymethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (488) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (489) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-cyclopentyl-7′,12′,13′,16′,20′,34′,37′-heptamethyl-36′-(pyridin-3-ylmethyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (490) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-8-cyclopropyl-11-isobutyl-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (491) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (492) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-8-[(2-fluorophenyl)methyl]-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (493) (3S,6R,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-30-isobutyl-3-isopropyl-1,4,6,10,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (494) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (495) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)-18-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (496) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-((R)-1-hydroxyethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (497) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-8-((R)-1-methoxyethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (498) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methy]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-6-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (499) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-2-[(3-chlorophenyl)methyl]-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-7,16,19,22,25,30,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (500) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-(thiazol-4-ylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (501) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-(cyclopentylmethyl)-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (502) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-8-[(4-chlorophenyl)methyl]-9-[(2-hydroxy-2-methyl-propoxy)methyl]-3-isobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (503) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18,28-bis[(1 S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (504) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-13-ethyl-21-isobutyl-28-isopropyl-7,10,16,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (505) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (506) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-36-ethyl-11-isobutyl-5,6,12,16,19,33-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (507) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,22,26,29,31,31,32-undecamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (508) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (509) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-5,6,12,16,19,33,36-heptamethyl-11-pentyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (510) (3S,9S,18S,21S,25R,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-36-ethoxy-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (511) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopropylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (512) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-9-isobutyl-3-isopropyl-4,7,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazabicyclo[32.4.0]octatriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (513) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-8-[(4-chlorophenyl)methyl]-9-[(5-fluoro-3-pyridyl)methoxymethyl]-3-isobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (514) (6&#39;S,9&#39;S,13&#39;S,16&#39;S,25&#39;S,31&#39;S,38a&#39;S)-16′-((S)-sec-butyl)-31′-(3-chloro-4-(trifluoromethyl)phenethyl)-6′-cyclohexyl-25′-(cyclohexylmethyl)-13′-isobutyl-5′,8′,12′,18′,21′,24′,27′-heptamethyl-9′-(piperidine-1-carbonyl)-5′,6′,9′,10′,12′,13′,15′,16′,18′,19′,21′,22′,24′,25′,27′,28′,30′,31′,38′,38a′-icosahydro-4′H-spiro[cyclopentane-1,3′-[1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontino[10,9-a]indol]-1′,4′,7′,11′,14′,17′,20′,23′,26′,29′,32′(2′H,8′H)-undecaone,   (515) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (516) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,33′R,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(cyclohexylmethyl)-19′-isopropyl-7′,12′,13′,16′,20′,33′,34′,37′-octamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (517) (3S,6S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-6-[(5-fluoro-3-pyridyl)methoxymethyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (518) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1 S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-21-(2,2,2-trifluoroethoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (519) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-(3-pyridylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (520) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (521) (6S,9R,13S,16S,25S,31S,33aS,37aS,38aS)-16-((S)-sec-butyl)-25-(4-chlorobenzyl)-6-isobutyl-3,3,5,9,12,13,18,21,24,27-decamethyl-31-(4-(trifluoromethyl)phenethyl)octacosahydro-[1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontino[10,9-a]indol-1,4,7,11,14,17,20,23,26,29,32(8H)-undecaone,   (522) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29,31,31-nonamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (523) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-8-(3,3-difluoropropyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (524) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-cyclobutyl-18-cyclopentyl-11-isobutyl-5,6,12,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)-16-propyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (525) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-25-ethoxy-36-ethyl-11-isobutyl-5,12,15,16,19,33-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (526) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-cyclohexyl-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (527) (6S,9S,13S,16S,22S,25S,31S,34S)-22-benzyl-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-4,10,14,17,23,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (528) (3S,9S,18S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-25-[(4-fluorophenyl)methyl]-7,10,13,16,26,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,23,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,24,27,30,33-undecone,   (529) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (530) (6&#39;S,9&#39;S,13&#39;S,16&#39;S,21a&#39;S,27&#39;S,33&#39;S,38a&#39;S)-6′-((S)-sec-butyl)-27′-(4-chlorophenethyl)-33′-(cyclohexylmethyl)-9′-isobutyl-16′-isopropyl-10′,14′,17′,31′,34′,37′-hexamethyl-13′-(piperidine-1-carbonyl)docosahydro-1′H-spiro[cyclopentane-1,19′-dipyrrolo[1,2-g:1′,2′-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,15′,18′,21′,26′,29′,32′,35′,38′(12′H,20′H,38a′H)-undecaone,   (531) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-12-ethyl-11-isobutyl-5,6,15,19,33,36-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (532) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-26-ethyl-7,10,13,16,21,22,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (533) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-18-cyclopropyl-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (534) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-8-propyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (535) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-18-I[(1R)-1-methoxyethyl]-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (536) (3S,6S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-6-(cyclohexylmethyl)-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (537) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9,18-bis(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (538) (3S,6S,10R,13S,19S,22S,28S,34S)-28-[(4-chlorophenyl)methyl]-13,19-diisobutyl-6-isopropyl-7,10,14,20,26,29,32-heptamethyl-3-[(1S)-1-methylpropyl]-22-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,4,7,11,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-16,1′-cyclopentane]-2,5,8,12,15,18,21,24,27,30,33-undecone,   (539) (3S,6R,9S,18S,21S,25R,28S,34S)-9-[(2-chlorophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (540) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (541) (3S,9S,18S,21S,25R,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-36-ethoxy-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1 S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (542) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-16-cyclopropyl-21-isobutyl-28-isopropyl-7,10,13,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (543) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-10-ethyl-21-isobutyl-7,13,16,22,26,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (544) (3S,9S,18S,21S,25S,28S,34S,36S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-36-hydroxy-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (545) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (546) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,10,16,19,22,25,30,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (547) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (548) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-28-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (549) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(4-chlorobenzyl)-19′-cyclopentyl-7′,12′,13′,16′,20′,34′,37′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (550) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-18-(cyclopropylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (551) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-21-prop-2-ynyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (552) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18,28-dicyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (553) (8S,11S,15S,18S,23aS,29S,31aR,38S,40aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-38-(cyclohexylmethyl)-18-isopropyl-6,11,12,16,19,39-hexamethyl-15-(piperidine-1-carbonyl)tetracosahydro-2H,4H,28H-spiro[azeto[2,1-u]pyrido[2,1-o]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,37,40(14H,22H,31aH)-undecaone,   (554) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-prop-2-ynyl-spiro[11,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (555) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-35-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (556) (3S,9S,12S,18S,27S,30S,34S)-9-[(2-fluorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (557) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,19,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-(3-pyridylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (558) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (559) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-11-(prop-2-yn-1-yl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (560) (3S,9S,18S,21S,25R,28S,31S,34S)-9-[(4-chlorophenyl)methyl]-28-isobutyl-31-isopropyl-7,10,13,16,21,22,25,29,32-nonamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (561) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-(cyclopropylmethyl)-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (562) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (563) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (564) 4-[[(3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-9-yl]methyl]benzonitrile,   (565) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-cyclopropyl-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (566) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-9-butyl-18-[(4-chlorophenyl)methyl]-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,30-diisobutyl-1,7,16,19,22,25,31,34-octamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (567) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(propoxymethyl)-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (568) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-N,N,5,6,12,19,33,36-octamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (569) (6S,12S,21S,24S,26aR,30aR,33S,38aS)-21-((S)-sec-butyl)-6-(3-chloro-4-(trifluoromethyl)phenethyl)-12-(cyclohexylmethyl)-24-isobutyl-33-isopropyl-10,13,16,19,34-pentamethylhexacosahydro-5H-spiro[benzo[f1]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-36,1′-cyclopentan]-5,8,11,14,17,20,23,26,32,35,38(26aH,37H)-undecaone,   (570) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-cyclopentyl-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (571) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-N,N,5,6,12,16,19,33-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (572) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11,35-bis(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (573) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,12,15,16,19,33-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (574) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,12,15,16,19,33-hexamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (575) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,22,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (576) (3S,9S,18S,21S,25R,28S,34S)-3-[2-(4-chlorophenyl)ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (577) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9,28-bis(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (578) (3S,9S,18S,21S,25R,28S,34S)-9-[(4-chlorophenyl)methyl]-21-(cyclohexylmethyl)-28-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (579) (3S,9S,18S,21S,25R,28S,34S)-28-cyclohexyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (580) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-8-cyclobutyl-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (581) (6&#39;S,12&#39;S,21&#39;S,23a&#39;S,31′R,34&#39;S,39a&#39;S)-21′-((S)-sec-butyl)-6′-(3-chloro-4-(trifluoromethyl)phenethyl)-12′-(cyclohexylmethyl)-34′-isopropyl-10′,13′,16′,19′,31′,35′-hexamethyltetracosahydrospiro[cyclopentane-1,37′-pyrido[1,2-a]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,23′,29′,33′,36′,39′(23a′H,30′H,38′H)-undecaone,   (582) (3S,6S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-6-[(2-hydroxy-2-methyl-propoxy)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (583) (8S,11S,17S,26S,29S,33R,36S)-17-[(4-chlorophenyl)methyl]-29-(cyclohexylmethyl)-8,36-diisobutyl-9,15,18,21,24,30,33,37-octamethyl-26-[(1S)-1-methylpropyl]-11-[2-[4-(trifluoromethyl)phenyl]ethyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (584) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-35-(4-fluorobenzyl)-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (585) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-(cyclobutoxymethyl)-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (586) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopentyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (587) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (588) (3S,6S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-6-isopropyl-4,7,10,16,19,22,25,30,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (589) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (590) 3-[(8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-8-yl]-N-methyl-propanamide,   (591) (3S,9S,18S,21S,25S,28S,31S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29,31-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (592) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-8-[(6-methoxy-3-pyridyl)methyl]-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (593) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (594) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (595) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-30-(cyclohexylmethyl)-3,9-diisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (596) (3S,9S,12S,18S,27S,30S,34S)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-9-(o-tolylmethyl)-34-(piperidine-1-carbonyl)-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (597) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-cyclopentyl-36′-(3,4-difluorobenzyl)-7′,12′,13′,16′,20′,34′,37′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (598) (5S,8S,11S,15R,18S,21R,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-21-isopropyl-5,6,12,15,19,33,36-heptamethyl-35-(4-methylbenzyl)tetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (599) (8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (600) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclohexane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (601) (8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-6,11,12,15,19,32,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (602) (3S,9S,12S,18S,27S,30S,34R)-22-butyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,6,6,10,16,19,25,30,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (603) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-18-[(1R)-1-hydroxyethyl]-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[11,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (604) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-19-benzyl-25-[(3-iodophenyl)methyl]-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,9,10,14,20,22,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(pyrrolidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (605) (3S,9S,18S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-25-[(2-hydroxy-2-methyl-propoxy)methyl]-7,10,13,16,26,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,23,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,24,27,30,33-undecone,   (606) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclohexyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (607) (8S,11S,17S,26S,29S,33S,36S)-11-[2-(4-chlorophenyl)ethyl]-8-[(2-chlorophenyl)methyl]-17-(cyclohexylmethyl)-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(pyrrolidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (608) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (609) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-12-[(3-chlorophenyl)methyl]-18-[(4-chlorophenyl)methyl]-3-isopropyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-9-(m-tolylmethyl)-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (610) (8S,11S,17S,26S,29S,33S,36S)-17-[(4-chlorophenyl)methyl]-8,36-diisobutyl-29-isopropyl-9,15,18,21,24,30,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-11-[2-[4-(trifluoromethyl)phenyl]ethyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (611) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (612) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-12-[(3-chlorophenyl)methyl]-18-[(4-chlorophenyl)methyl]-3-isopropyl-4,7,9,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (613) (3S,6S,9S,12S,18S,27S,30S,34S)-6,12-dibenzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (614) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-22-[(6-methoxy-3-pyridyl)methyl]-4,10,14,17,23,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (615) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-30-(cyclohexylmethyl)-3,9-diisobutyl-4,6,6,10,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (616) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(2-fluorophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (617) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-22-(2-phenylethyl)-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (618) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-(4-fluorophenyl)ethyl]-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (619) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,9,16,19,22,25,31-octamethyl-27-I[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (620) (3S,9S,18S,21S,25S,28S,31S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-31-ethyl-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29,31-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (621) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-9-isobutyl-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (622) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-5,6,12,16,19,33,36-heptamethyl-11-pentyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (623) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-9-(methoxymethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (624) (3S,6S,9S,12S,18S,27S,30S,34S)-9-[(2-chlorophenyl)methyl]-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-3-isopropyl-1,4,6,10,16,19,22,25,30,31-decamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (625) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chlorophenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,16,19,33,36-octamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (626) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (627) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-18-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (628) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (629) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (630) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (631) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(5,5-difluoropentyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (632) (6S,12S,21S,23aS,31R,34S,37S,39aS)-37-benzyl-21-((S)-sec-butyl)-12-(4-chlorobenzyl)-34-isobutyl-10,13,16,19,31,35,38-heptamethyl-6-(4-(trifluoromethyl)phenethyl)tetracosahydro-1H-pyrido[1,2-a]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-5,8,11,14,17,20,23,29,33,36,39(23aH,30H,39aH)-undecaone,   (633) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-3-(3-phenylpropyl)-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (634) (3S,9S,18S,21S,25S,28S,31S,34S,36R)-31-benzyl-9-[(4-chlorophenyl)methyl]-36-ethoxy-3-[(3-iodophenyl)methyl]-28-isobutyl-7,10,13,16,21,22,29,32-octamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (635) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-16-[2-(4,4-difluoro-1-piperidyl)ethyl]-21-isobutyl-28-isopropyl-7,10,13,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (636) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-11-(methoxymethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (637) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (638) (6S,9S,13S,16S,22S,25S,31S,34S)-22-[(2-fluorophenyl)methyl]-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (639) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-((R)-1-methoxyethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (640) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-25-ethoxy-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (641) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29,31,31-nonamethyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (642) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-8-cyclohexyl-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (643) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-8-(cyclopentylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (644) (3S,9S,18S,21S,25R,28S,31S,34S)-31-allyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29,31-nonamethyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (645) (6S,9S,13R,16S,22S,25S,31S,34S)-31-[(4-chlorophenyl)methyl]-16,22-diisobutyl-9-isopropyl-4,10,13,17,23,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-25-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (646) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-8-[(4-chlorophenyl)methyl]-12-[2-(4-fluorophenyl)ethyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (647) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (648) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,15,19,33,36-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (649) (4R,7S,13S,16S,22S,31S,34S)-22-(cyclohexylmethyl)-16-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-7,13-diisobutyl-4,5,10,10,11,20,23,26,29-nonamethyl-31-[(1S)-1-methylpropyl]-1,5,8,11,14,17,20,23,26,29,32-undecazabicyclo[32.4.0]octatriacontane-2,6,9,12,15,18,21,24,27,30,33-undecone,   (650) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-(2-methoxyethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (651) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-35-ethyl-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (652) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-25-ethoxy-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (653) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-(5,5-difluoropentyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (654) (3S,9S,18S,21S,25R,28S,31S,34S)-31-benzyl-9-[(4-chlorophenyl)methyl]-28-isobutyl-7,10,13,16,21,22,25,29,32-nonamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (655) (3S,6S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(3,3-difluoroazetidin-1-yl)ethyl]-3-isopropyl-6-(methoxymethyl)-1,4,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (656) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-(4-pyridylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (657) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-12-[(3-chloro-5-fluoro-phenyl)methyl]-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (658) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-30-isopropyl-4,6,6,10,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (659) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,16,19,33,36-octamethyl-29-(3-phenylpropyl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (660) (5S,8S,11S,15S,18S,21S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-21-isopropyl-N,N,5,6,12,16,19,33-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxohexatriacontahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-15-carboxamide,   (661) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-((isopentyloxy)methyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (662) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[36-oxa-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.4.0]octatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (663) (8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (664) (3S,9S,18S,21S,25R,28S,34S)-9-[(4-chlorophenyl)methyl]-28-isobutyl-7,10,13,16,21,22,25,29,31,31-decamethyl-8-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (665) (3S,9S,18S,21S,25R,28S,31R,34S)-31-allyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29,31-octamethyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (666) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,32a′R,38&#39;S,40a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-38′-(cyclohexylmethyl)-19′-isopropyl-7′,12′,13′,16′,20′,39′-hexamethylhexacosahydro-5′H-spiro[cyclopentane-1,22′-tripyrrolo[2,1-i:2′,1′-o:2″,1″-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,37′,40′(15′H,23′H)-undecaone,   (667) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-12-ethyl-11-isobutyl-18-isopropyl-5,6,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (668) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (669) (8S,11S,17S,26S,29S,33R,36S)-17-[(4-chlorophenyl)methyl]-8,36-diisobutyl-29-isopropyl-9,15,18,21,24,30,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-prop-2-ynyl-11-[2-[4-(trifluoromethyl)phenyl]ethyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (670) (6&#39;S,12&#39;S,21&#39;S,23a&#39;S,31&#39;S,34&#39;S,39a&#39;S)-21′-((S)-sec-butyl)-12′-(cyclohexylmethyl)-6′-(3-fluoro-4-(trifluoromethyl)phenethyl)-34′-isopropyl-10′,13′,16′,19′,32′,35′-hexamethyl-31′-(piperidine-1-carbonyl)tetracosahydrospiro[cyclopentane-1,37′-pyrido[1,2-a]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,23′,29′,33′,36′,39′(23a′H,30′H,38′H)-undecaone,   (671) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-35-benzyl-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (672) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclobutyl-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (673) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,12,15,16,19,33-hexamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (674) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-35-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (675) (3S,6S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-6-(isopentyloxymethyl)-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (676) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-(cyclopropoxymethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (677) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-N,N,5,6,12,19,33,36-octamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (678) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (679) (3S,6S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(3,3-difluoroazetidin-1-yl)-2-oxo-ethyl]-3-isopropyl-1,4,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-6-(2,2,2-trifluoroethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (680) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(4-chlorobenzyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (681) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-12-[(2-fluorophenyl)methyl]-3,30-diisobutyl-6,18-bis[(4-methoxyphenyl)methyl]-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (682) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-22-[2-(3,3-difluoro-1-piperidyl)ethyl]-16-isopropyl-3,4,9,10,14,17,23,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (683) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-9-(p-tolylmethyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (684) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(propoxymethyl)-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (685) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-29-(3-fluorophenethyl)-18-isopropyl-5,6,11,12,16,19,33,36-octamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (686) (3S,6S,9S,13R,16S,22S,25S,31S,34S)-31-(cyclohexylmethyl)-25-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-9,16,22-triisobutyl-3,4,10,13,14,19,19,20,29,32-decamethyl-6-[(1S)-1-methylpropyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (687) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-12-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (688) 2-[(8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-8-yl]acetic acid   (689) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-18-(cyclopropylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[11,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (690) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (691) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-butyl-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclopentylmethyl)-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (692) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-(propoxymethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (693) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (694) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (695) (3S,9S,18S,21S,25R,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18,28-bis[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (696) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-8-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-6-(o-tolylmethyl)-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (697) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,22,25,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (698) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-25-ethoxy-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (699) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-(cyclobutoxymethyl)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (700) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,19,33,36-hexamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (701) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (702) (3S,6R,9S,12S,18S,27S,30S,34S)-9-[(2-chlorophenyl)methyl]-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-3-isopropyl-1,4,6,10,16,19,22,25,30,31-decamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (703) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-22-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (704) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-5,6,12,15,16,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (705) (3S,9S,18S,21S,25R,28S,31S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21,31-diisobutyl-28-isopropyl-7,10,13,16,22,25,29,31-octamethyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (706) (3S,9S,12S,18S,27S,30S,34S)-9-[(2-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (707) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-(cyclopropylmethyl)-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (708) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18,28-bis[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (709) (6S,9S,13S,16S,21aS,27S,33S,35aS,39aS)-6-((S)-sec-butyl)-27-(3-chloro-4-(trifluoromethyl)phenethyl)-33-(cyclohexylmethyl)-9-isobutyl-16-isopropyl-10,14,17,31,34-pentamethyl-13-(piperidine-1-carbonyl)docosahydro-1H,26H-spiro[azeto[1,2-j]dipyrrolo[1,2-g:1′,2′-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-19,1′-cyclopentan]-5,8,11,15,18,21,26,29,32,35,39(12H,20H,35aH,39aH)-undecaone,   (710) 3-[[(3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-9-yl]methyl]benzonitrile,   (711) (3S,9S,12S,18S,27S,30S,34S)-18-(cyclohexylmethyl)-9-[(4-fluorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (712) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (713) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (714) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,22,25,26,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (715) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,19,22,23,29,32-dodecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (716) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)-18-prop-2-ynyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (717) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (718) (8S,11S,17S,26S,29S,33S,36S)-8-[(4-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (719) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-13-(azetidine-1-carbonyl)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (720) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(4-chlorobenzyl)-18-cyclopentyl-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (721) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (722) (3S,6S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-6,7,10,13,16,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (723) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-(cyclobutylmethyl)-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (724) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclohexyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (725) (8S,11S,15S,18S,23aS,31S,37S,39aS)-8-((S)-sec-butyl)-31-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-37-(cyclohexylmethyl)-11-isobutyl-6,12,16,19,35,38-hexamethyl-15-(piperidine-1-carbonyl)-1,5,6,8,9,11,12,15,16,18,19,23a,24,31,32,34,35,37,38,39a-icosahydro-2H,4H-spiro[azeto[2′,1′:21,22][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontino[10,9-a]indole-21,1′-cyclopentan]-4,7,10,13,17,20,23,30,33,36,39(14H,22H)-undecaone,   (726) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-33-ethyl-11-isobutyl-5,6,12,16,19,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (727)N-tert-butyl-2-[[(8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-8-yl]methoxy]acetamide,   (728) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.4.0]octatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (729) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-8-(3-methylbut-2-en-1-yl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (730) (8S,11S,17S,26S,29S,33S,36S)-8-butyl-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (731) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (732) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-(2,2,2-trifluoroethoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (733) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-8-(cyclobutylmethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (734) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (735) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(propoxymethyl)-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (736) (3S,6S,9S,13S,16S,19S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,19,22,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (737) (3S,9S,18S,21S,25S,28S,34S)-25-(4-tert-butylpiperidine-1-carbonyl)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (738) (3S,9S,18S,21S,25R,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (739) (3S,6S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-6-(propoxymethyl)-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (740) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,9-diisobutyl-30-isopropyl-4,6,6,10,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (741) (5S,8S,11S,15S,18S,21S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18,21-diisopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)tetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (742) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21,28-diisobutyl-7,10,13,16,22,25,26,29-octamethyl-8-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,4′-tetrahydropyran]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (743) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-25-ethoxy-36-ethyl-11-isobutyl-5,12,15,16,19,33-hexamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (744) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-(2-methoxyethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (745) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-allyl-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (746) (7&#39;S,16&#39;S,19&#39;S,23′R,26&#39;S,31a&#39;S,37&#39;S,39a′R)-16′-((S)-sec-butyl)-37′-(3-chloro-4-(trifluoromethyl)phenethyl)-7′-(cyclohexylmethyl)-26′-isopropyl-8′,11′,14′,19′,20′,23′,27′-heptamethyltetracosahydro-2′H,6′H-spiro[cyclopentane-1,29′-pyrido[2,1-o]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-6′,9′,12′,15′,18′,21′,25′,28′,31′,36′,39′(22′H,30′H)-undecaone,   (747) (6&#39;S,12&#39;S,21&#39;S,24&#39;S,27a′R,34&#39;S,39a&#39;S)-21′-((S)-sec-butyl)-6′-(3-chloro-4-(trifluoromethyl)phenethyl)-12′-(cyclohexylmethyl)-24′-isobutyl-34′-isopropyl-10′,13′,16′,19′,25′,35′-hexamethylhexacosahydrospiro[cyclopentane-1,37′-pyrido[1,2-e1]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,23′,26′,33′,36′,39′(38′H)-undecaone,   (748) (3S,6R,9S,12S,18S,27S,30S,34S)-6-allyl-9-[(2-chlorophenyl)methyl]-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-3-isopropyl-1,4,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (749) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-cyclopentyl-7′,12′,13′,16′,20′,34′,37′-heptamethyl-36′-(4-(trifluoromethyl)benzyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (750) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (751) (3S,9S,18S,21S,25R,28S,31S,34S)-31-benzyl-9-[(4-chlorophenyl)methyl]-28-isobutyl-7,10,13,16,21,22,25,29,32-nonamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (752) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-9-isobutyl-3-isopropyl-4,7,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (753) (3S,9S,18S,25R,28S,34S)-25-benzyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-7,10,13,16,23,26,29-heptamethyl-8-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,23,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,24,27,30,33-undecone,   (754) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-22-[(2-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (755) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-(cyclobutoxymethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (756) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-[(1R)-1-hydroxyethyl]-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (757) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-4,10,14,17,23,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-(3-pyridylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (758) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-2-[(3-chlorophenyl)methyl]-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (759)N-tert-butyl-2-[[(8S,11S,17S,26S,29S,33S,36S)-17-[(4-chlorophenyl)methyl]-8,36-diisobutyl-29-isopropyl-9,15,18,21,24,30,37-heptamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-11-[2-[4-(trifluoromethyl)phenyl]ethyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-33-yl]methoxy]acetamide,   (760) (2aS,5S,11S,14S,20S,23S,30aS,33S)-33-((S)-sec-butyl)-14-butyl-11-(3-chloro-4-(trifluoromethyl)phenethyl)-5-(cyclohexylmethyl)-20-isobutyl-4,7,16,17,17,22,35-heptamethyl-23-(piperidine-1-carbonyl)tetracosahydroazeto[1,2-j]pyrido[1,2-a][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-3,6,9,12,15,18,21,25,31,34,37(1H,22H,27H)-undecaone,   (761) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(3,3-difluoroazetidin-1-yl)-2-oxo-ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (762) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopentyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (764) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-9-tert-butyl-18-[(4-chlorophenyl)methyl]-3-isobutyl-4,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (765) (3S,9S,12S,18S,27S,30S,34S)-3,9-dibutyl-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-30-isobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (766) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-18-(prop-2-yn-1-yl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (767) 2-[[(3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-9-yl]methyl]benzonitrile,   (768) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isopentyl-5,12,16,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (769) (8S,11S,17S,26S,29S,33S,36S)-17-[(4-chlorophenyl)methyl]-8,36-diisobutyl-29-isopropyl-9,15,18,21,24,30,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(pyrrolidine-1-carbonyl)-11-[2-[4-(trifluoromethyl)phenyl]ethyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (770) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-22-[(5-methoxy-3-pyridyl)methyl]-4,10,14,17,23,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (771) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-(cyclopropylmethyl)-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (772) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-9-cyclohexyl-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (773) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-isopropyl-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (774) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (775) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (776) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (777) (3S,6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-9-isobutyl-3,4,10,13,14,17,23,29,32-nonamethyl-6-[(1S)-1-methylpropyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (778) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-21-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (779) (3S,6S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-6-(5,5-difluoropentyl)-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (780) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-13-(1,1-dioxo-1,4-thiazinane-4-carbonyl)-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (781) (6S,9S,13S,16S,22S,25S,31S,34S)-22-[(2-chlorophenyl)methyl]-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (782) (6S,9S,13R,16S,19S,22S,25S,31S,34S)-19-benzyl-31-[(4-chlorophenyl)methyl]-25-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-22-isobutyl-16-isopropyl-4,9,10,13,17,20,23,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (783) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[(3-chlorophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (784) (5S,8S,11S,15S,18S,21S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-21-isopropyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxohexatriacontahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-15-carboxamide,   (785) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,12,15,16,19,33-hexamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (786) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-4,10,14,17,23,29,32-heptamethyl-6-I[(1S)-1-methylpropyl]-22-[(6-methyl-3-pyridyl)methyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (787) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-(cyclopropylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (788) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,6,6,10,16,19,22,25,30,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (789) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-8-[(2-hydroxy-2-methyl-propoxy)methyl]-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (790) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-35-(cyclohexylmethyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (791) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-22-[[2-(trifluoromethyl)phenyl]methyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (792) allyl 2-[(8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-8-yl]acetate,   (793) (3S,6S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(3,3-difluoroazetidin-1-yl)-2-oxo-ethyl]-3-isopropyl-6-(methoxymethyl)-1,4,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (794) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-18-(isopentyloxymethyl)-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (795) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-35-(3-fluorobenzyl)-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (796) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-8-(5,5-difluoropentyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (797) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (798) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11,15-diisobutyl-5,6,12,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (799) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (800) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-9,30-diisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-3,27-bis[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (801) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-13-isopentyl-28-isopropyl-7,10,16,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (802) (3S,9S,18S,21S,25R,28S,34S)-3-[2-(4-chlorophenyl)ethyl]-9-(cyclohexylmethyl)-21,28-diisobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,4′-tetrahydropyran]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (803) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-(cyclobutoxymethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (804) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (805) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,19,23,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-22-(thiazol-4-ylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (806) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isopentyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (807) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (808) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,30,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (809) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)-5-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (810) 3-((5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-5-yl)-N-methylpropanamide,   (811) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-cyclobutyl-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (812) (5S,8S,11S,15S,18S,23aS,31S,37S,39aS)-8-((S)-sec-butyl)-31-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-37-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,35,38-heptamethyl-15-(piperidine-1-carbonyl)-1,5,6,8,9,11,12,15,16,18,19,23a,24,31,32,34,35,37,38,39a-icosahydro-2H,4H-spiro[azeto[2′,1′:21,22][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontino[10,9-a]indole-21,1′-cyclopentan]-4,7,10,13,17,20,23,30,33,36,39(14H,22H)-undecaone,   (813) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-8-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-6-[[2-(trifluoromethyl)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (814) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (815) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (816) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (817) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(3,3-difluoroazetidin-1-yl)ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-19-(propoxymethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (818) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[2-(3,3-difluoro-1-piperidyl)ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (819) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-8-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-6-[[4-(trifluoromethoxy)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (820) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-[(1R)-1-methoxyethyl]-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (821) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-8-[(4-fluorophenyl)methyl]-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (822) (5S,8S,11S,15S,18S,20aR,26S,29S,35S,37aS)-8-((S)-sec-butyl)-26-butyl-29-(3-iodobenzyl)-11,18-diisobutyl-5,6,12,16,33,36-hexamethyl-35-(4-methylbenzyl)-15-(piperidine-1-carbonyl)tetracosahydro-4H-azeto[2,1-u]pyrrolo[2,1-f][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,25,28,31,34,37(2H,14H)-undecaone,   (823) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,30&#39;S,32a′R,39&#39;S,41a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-39′-(cyclohexylmethyl)-19′-isopropyl-7′,12′,13′,17′,20′,40′-hexamethyl-16′-(piperidine-1-carbonyl)hexacosahydro-5′H,29′H-spiro[cyclopentane-1,22′-pyrido[2,1-o]dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,38′,41′(15′H,23′H,32a′H)-undecaone,   (824) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-22-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (825) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-(3,4-dichlorophenyl)ethyl]-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (826) (3S,6S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-6-isobutyl-3-isopropyl-1,4,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (827) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (828) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxohexatriacontahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-15-carboxamide,   (829) (5S,8S,11S,15S,18S,21S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,21,33,36-decamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxohexatriacontahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-15-carboxamide,   (830) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-9-[(3-fluorophenyl)methyl]-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (831) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (832) (3S,9S,12S,18S,27S,30S)-18-(cyclohexylmethyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (833) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-36-ethyl-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (834) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,32a′R,39&#39;S,41a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-39′-(cyclohexylmethyl)-19′-isopropyl-7′,12′,13′,16′,20′,40′-hexamethylhexacosahydro-5′H,29′H-spiro[cyclopentane-1,22′-pyrido[2,1-o]dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,38′,41′(15′H,23′H,32a′H)-undecaone,   (835) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclobutoxymethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (836) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(propoxymethyl)-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (837) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (838) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[(4-chlorophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (839) (3S,9S,12S,18S,27S,30S,34R)-18-(cyclohexylmethyl)-3,9,30-triisobutyl-4,6,6,10,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (840) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,12,16,19,33,36-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (841) (6&#39;S,12&#39;S,21&#39;S,23a&#39;S,31&#39;S,34&#39;S,39a&#39;S)-21′-((S)-sec-butyl)-6′-(4-chlorophenethyl)-12′-(cyclohexylmethyl)-34′-isopropyl-10′,13′,16′,19′,32′,35′-hexamethyl-31′-(piperidine-1-carbonyl)tetracosahydrospiro[cyclopentane-1,37′-pyrido[1,2-a]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,23′,29′,33′,36′,39′(23a′H,30′H,38′H)-undecaone,   (842) (3S,9S,12S,18S,27S,30S,34R)-18-(cyclohexylmethyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9-diisobutyl-1,6,6,7,16,19,22,25,30,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (843) (8S,11S,17S,26S,29S,33R,36S)-17-[(4-chlorophenyl)methyl]-8,29,36-triisobutyl-9,15,18,21,24,30,33,37-octamethyl-26-[(1S)-1-methylpropyl]-11-[2-[4-(trifluoromethyl)phenyl]ethyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (844) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-cyclopropyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-8-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (845) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclobutyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (847) (4R,7S,13S,16S,22S,31S,34S)-22-[(4-chlorophenyl)methyl]-7,13-diisobutyl-4,8,14,20,23,26,29-heptamethyl-31-[(1S)-1-methylpropyl]-16-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,5,8,11,14,17,20,23,26,29,32-undecazabicyclo[32.4.0]octatriacontane-10,1′-cyclopentane]-2,6,9,12,15,18,21,24,27,30,33-undecone,   (848) (11S,17S,26S,29S,33S,36S)-9-butyl-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (849) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21,28-dicyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (850) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-(methoxymethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (851) (8S,11S,17S,26S,29S,33R,36S)-17-[(4-chlorophenyl)methyl]-11-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-8,36-diisobutyl-29-isopropyl-9,15,18,21,24,30,33,37-octamethyl-26-[(1S)-1-methylpropyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (852) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyl-5-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (853) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-9-(propoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (854) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-benzyl-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (855) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,32&#39;S,38&#39;S,40a&#39;S)-9′-((S)-sec-butyl)-32′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-cyclohexyl-38′-(cyclohexylmethyl)-12′-isobutyl-7′,13′,17′,20′,36′,39′-hexamethyl-16′-(piperidine-1-carbonyl)-1′,2′,3′,6′,7′,9′,10′,12′,13′,16′,17′,19′,20′,24a′,25′,32′,33′,35′,36′,38′,39′,40a′-docosahydro-5′H-spiro[cyclopentane-1,22′-pyrrolo[2′,1′:21,22][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontino[10,9-a]indol]-5′,8′,11′,14′,18′,21′,24′,31′,34′,37′,40′(15′H,23′H)-undecaone,   (856) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,19,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-(thiazol-4-ylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (857) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-cyclopentyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (858) (3S,9S,12S,18S,27S,30S,34R)-18-(cyclohexylmethyl)-9-[[4-(difluoromethyl)phenyl]methyl]-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (859) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-35-(cyclohexylmethyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (860) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-29-(4-fluorophenethyl)-18-isopropyl-5,6,11,12,16,19,33,36-octamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (861) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (862) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-((R)-1-hydroxyethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (863) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (864) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-13-(2-ethoxyethyl)-21-isobutyl-28-isopropyl-7,10,16,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (865) (3S,9S,18S,21S,25R,28S,31S,34S)-31-benzyl-9-[(4-chlorophenyl)methyl]-28-isopropyl-7,10,13,16,21,22,25,29,32-nonamethyl-8-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (866) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-N,N,5,6,12,16,19,33-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (867) 4-[[(3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-9-yl]methyl]benzonitrile,   (868) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-35-(cyclohexylmethyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (869) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18,28-bis[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (870) (3S,9S,18S,21S,25R,28S,31S,34S)-31-benzyl-9-[(4-chlorophenyl)methyl]-36,36-difluoro-28-isobutyl-7,10,13,16,21,22,25,29,32-nonamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (871) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18,35-dicyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (872) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(2-ethoxyethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (873) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-cyclohexyl-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (874) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopropyl-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (875) (3S,9S,18S,21S,25S,28S,34S,36R)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-36-hydroxy-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (876) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-8-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-6-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (877) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9,28-dicyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (878) (3S,6S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-6-(2-phenylethyl)-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (879) (3S,9S,18S,21S,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (880) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclobutoxymethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (881) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (882) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (883) (3S,9S,12S,18S,27S,30S,34R)-18-(cyclohexylmethyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (884) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-8-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (885) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclobutoxymethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (886) (3S,6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-9,16,22-triisobutyl-3,4,10,13,14,19,19,20,29,32-decamethyl-6-[(1S)-1-methylpropyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (887) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-8-[(5-methoxy-3-pyridyl)methyl]-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (888) 4-[[(3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-9-yl]methyl]benzonitrile,   (889)N-tert-butyl-2-[[(3S,6S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-6-yl]methoxy]acetamide,   (890) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (891) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18,28-bis[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (892) (8S,11S,17S,26S,29S,33R,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-8,36-diisobutyl-29-isopropyl-9,15,18,21,24,30,33,37-octamethyl-26-[(1S)-1-methylpropyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (893) (3S,9S,18S,21S,25S,28S,34S)-3-[2-(4-chlorophenyl)ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (894) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)-18-(2,2,2-trifluoroethoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (895) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-19-ethyl-3,30-diisobutyl-1,6,6,7,16,22,25,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (896) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxo-11-pentyltetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (897) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-3-cyclohexyl-2-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-9,30-diisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (898) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (899) (11S,17S,26S,29S,33S,36S)-9-allyl-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (900) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (901) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-(cyclopentylmethyl)-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (902) (3S,9S,18S,21S,25R,28S,31S,34S)-9-[(4-chlorophenyl)methyl]-28,31-diisobutyl-7,10,13,16,21,22,25,29,32-nonamethyl-8-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (903) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(4-chlorophenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,16,19,33,36-octamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (904) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18,28-bis[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (905) (3S,6S,10R,13S,19S,22S,28S,34S)-28-(cyclohexylmethyl)-22-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-6,13,19-triisobutyl-7,10,11,16,16,17,26,29,32-nonamethyl-3-[(1S)-1-methylpropyl]-1,4,7,11,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,12,15,18,21,24,27,30,33-undecone,   (906) (7S,10S,16S,25S,28S,32S,35S)-7-[(2-chlorophenyl)methyl]-10-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-(cyclohexylmethyl)-35-isopropyl-8,14,17,20,23,28,29,33,36-nonamethyl-25-[(1S)-1-methylpropyl]-32-(pyrrolidine-1-carbonyl)-5,8,11,14,17,20,23,26,29,33,36-undecazaspiro[3.33]heptatriacontane-6,9,12,15,18,21,24,27,30,34,37-undecone,   (907) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (908) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-22-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (909) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-35-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (910) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(3,3-difluoro-1-piperidyl)ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (911) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-(cyclobutylmethyl)-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (912) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-22-(m-tolylmethyl)-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (913) (6S,9S,13R,16S,19S,22S,25S,31S,34S)-19-benzyl-31-[(4-chlorophenyl)methyl]-22-isobutyl-16-isopropyl-4,9,10,13,17,20,23,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-25-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (914) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-36-(4,4-difluoro-1-piperidyl)-28-isopropyl-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (915) (3S,6S,9S,13S,16S,19S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-19-isopropyl-N,N,3,4,10,14,17,22,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (916) (8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(4-chlorophenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (917) (3S,9S,18S,21S,25S,28S,31R,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29,31-octamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (918) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18,35-dicyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (919) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]-9-(3-pyridylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (920) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[(4-fluorophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (921) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-(cyclopentylmethyl)-5,12,16,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (922) (6S,9R,13S,16S,25S,31S,33aS,37aS,38aS)-16-((S)-sec-butyl)-25-(4-chlorobenzyl)-6,13-diisobutyl-3,3,5,9,12,18,21,24,27-nonamethyl-31-(4-(trifluoromethyl)phenethyl)octacosahydro-[1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontino[10,9-a]indol-1,4,7,11,14,17,20,23,26,29,32(8H)-undecaone,   (923) (8S,11S,17S,26S,29S,36S)-17-[(4-chlorophenyl)methyl]-8,36-diisobutyl-29-isopropyl-9,15,18,21,24,30,37-heptamethyl-26-[(1S)-1-methylpropyl]-11-[2-[4-(trifluoromethyl)phenyl]ethyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (924) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-18-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (925) (3S,9S,18S,21S,25S,28S,31S,34S,36R)-3-[(3-chlorophenyl)methyl]-9-[(4-chlorophenyl)methyl]-36-ethoxy-28-isobutyl-31-(isopentyloxymethyl)-7,10,13,16,21,22,29,32-octamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (926) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (927) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-1,4,7,16,19,22,25,30,31,34-decamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (928) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (929) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-35-((R)-1-methoxyethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (930) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopropylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (931) (6S,9S,13S,16S,22S,25S,31S,34S)-31-(cyclohexylmethyl)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-22-(2-phenylethyl)-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (932) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (933) (5S,8S,11S,15R,18S,21S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-21-isopropyl-5,6,12,15,19,33,36-heptamethyl-35-(4-methylbenzyl)tetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (934) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-6,18-bis[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (935) 2-[[(3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-9-yl]methyl]benzonitrile,   (936) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-cyclobutyl-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (937) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (938) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (939) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-29-isobutyl-36-isopropyl-8,9,15,18,21,24,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (940) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-8-(isopentyloxymethyl)-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (941) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-18-(2-methoxyethyl)-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (942) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-4,9,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-(3-pyridylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (943) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-9-(propoxymethyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (944) (3S,9S,18S,21S,25R,28S,31S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-31-ethyl-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29,31-nonamethyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (945) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-8-[(3-fluorophenyl)methyl]-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (946) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-8-(prop-2-yn-1-yl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (947) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-36-ethyl-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (948) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (949) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-36-ethyl-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (950) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-8-[(5-fluoro-3-pyridyl)methoxymethyl]-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (951) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25-ethoxy-36-ethyl-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (952) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (953) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(4-chlorophenethyl)-36′-(cyclohexylmethyl)-12′-isobutyl-19′-isopropyl-7′,13′,17′,20′,34′,37′-hexamethyl-16′-(piperidine-1-carbonyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (954) (3S,9S,18S,21S,25S,28S,34S)-3-[2-(3-chlorophenyl)ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-I[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (955)N-tert-butyl-2-[[(3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,29-hexamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-25-yl]methoxy]acetamide,   (956) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-27-isopropyl-1,6,6,7,16,19,22,25,31,34-decamethyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (957) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,22,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (958) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-benzyl-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (959) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-cyclobutyl-35-(cyclohexylmethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (960) (8S,11S,15S,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(cyclohexylmethyl)-11-isobutyl-6,12,16,19,33,36-hexamethyl-25-phenyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (961) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-11-(but-3-yn-1-yl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(4-iodobenzyl)-5,6,12,15,16,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (962) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (963) (8S,11S,17S,26S,29S,33S,36S)-8-[(2-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (964) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,30&#39;S,32a′R,38&#39;S,40a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-38′-(cyclohexylmethyl)-19′-isopropyl-7′,12′,13′,17′,20′,39′-hexamethyl-16′-(piperidine-1-carbonyl)hexacosahydro-5′H-spiro[cyclopentane-1,22′-tripyrrolo[2,1-i:2′,1′-o:2″,1″-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,37′,40′(15′H,23′H)-undecaone,   (965) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (966) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-8-cyclopentyl-11-isobutyl-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (967) (3S,9S,12S,18S,27S,30S,34R)-18-(cyclohexylmethyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-9,30-diisobutyl-3-isopropyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (968) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-(cyclobutylmethyl)-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (969) (3S,9S,12S,18S,27S,30S,34S)-18-(cyclohexylmethyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (970) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-16,21-diisobutyl-28-isopropyl-7,10,13,22,25,29-hexamethyl-8-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (971) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-11-(but-3-yn-1-yl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(4-iodobenzyl)-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (972) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-9,34-diisobutyl-3-isopropyl-4,7,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (973) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (974) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (975) 3-[[(3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-9-yl]methyl]benzonitrile,   (976) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,16,19,33,36-octamethyl-29-(4-methylphenethyl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (977) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (978) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-3-isobutyl-4,7,9,10,16,19,22,25,30,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (979) (3S,9S,18S,21S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (980) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-cyclopropyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (981) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-21-(2,2,2-trifluoroethyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (982) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-19-isopropyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-(thiazol-4-ylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (983) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9,21-bis(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (984) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (985) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (986) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9,18-bis(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (987) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(propoxymethyl)-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (988) (7S,10S,14S,17S,22aS,28S,34S,36aS,40aS)-7-((S)-sec-butyl)-28-(3-chloro-4-(trifluoromethyl)phenethyl)-34-(cyclohexylmethyl)-10-isobutyl-17-isopropyl-11,15,18,32,35-pentamethyl-14-(piperidine-1-carbonyl)tetracosahydro-27H-spiro[azeto[1,2-j]pyrido[1,2-g]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-20,1′-cyclopentan]-6,9,12,16,19,22,27,30,33,36,40(2H,13H,21H,36aH)-undecaone,   (989) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30-heptamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (990) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-35-(2-fluorobenzyl)-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (991) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-(cyclopentylmethyl)-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (992) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-25-(isopentyloxymethyl)-28-isopropyl-7,10,13,16,22,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (993) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,19,22,23,29,32-dodecamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (994) (6S,9S,13R,16S,19S,22S,25S,31S,34S)-19-benzyl-31-[(4-chlorophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-isobutyl-16-isopropyl-4,9,10,13,17,20,23,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (995) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-18-propyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (996) (1R,4S,7S,16S,22S,25S,31S,34R)-16-[(4-chlorophenyl)methyl]-25,31-diisobutyl-4-isopropyl-3,9,12,15,18,24,30-heptamethyl-7-[(1S)-1-methylpropyl]-22-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[3,6,9,12,15,18,21,24,27,30,33-undecazabicyclo[32.3.0]heptatriacontane-28,1′-cyclopentane]-2,5,8,11,14,17,20,23,26,29,32-undecone,   (997) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-8-[(4-chlorophenyl)methyl]-6-[(4-fluorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (998)N-(tert-butyl)-2-(((5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxo-15-(piperidine-1-carbonyl)tetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-5-yl)methoxy)acetamide,   (999) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-35-(cyclohexylmethyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1000) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(3-fluorophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1001) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-9-(p-tolylmethyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1002) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1003) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18,28-bis[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1004) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-36′-benzyl-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-cyclopentyl-7′,12′,13′,16′,20′,34′,37′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1005) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-propyl-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1006) (5S,8S,11S,15R,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-25-ethoxy-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1007) (3S,9S,18S,25S,28S,34S)-25-benzyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,26,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,23,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,24,27,30,33-undecone,   (1008) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1009) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[(2-chlorophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1010) (5S,8S,11S,15S,18S,21S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-21-isopropyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxohexatriacontahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-15-carboxamide,   (1011) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-5,6,11,12,15,19,32,33,36-nonamethyl-35-(pyridin-3-ylmethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1012) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1Si)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-(3-pyridylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1013) (3S,9S,18S,21S,25R,28S,34S)-9-[(4-chlorophenyl)methyl]-21,28-diisobutyl-7,10,13,16,22,25,29,31,31-nonamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1014) (8S,11S,17S,26S,29S,33R,36S)-17-[(4-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-8,36-diisobutyl-29-isopropyl-9,15,18,21,24,30,33,37-octamethyl-26-[(1S)-1-methylpropyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1015) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-benzyl-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1016) (5S,8S,11S,15S,18S,23aS,25S,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-25-phenyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1017) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1018) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(4-chlorobenzyl)-11-isobutyl-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1019) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-(cyclopropylmethyl)-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1020) (5S,8S,12R,15S,20aS,26S,32S,37aS)-5-((S)-sec-butyl)-26-(3-chloro-4-(trifluoromethyl)phenethyl)-32-(cyclohexylmethyl)-8-isobutyl-15-isopropyl-9,12,16,30,33,36-hexamethyldocosahydrospiro[azeto[1,2-g]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-18,1′-cyclopentan]-4,7,10,14,17,20,25,28,31,34,37(2H,11H,19H)-undecaone,   (1021) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(pentafluoro-□ 6 -sulfanyl)phenyl]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1022) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33,36-dodecone,   (1023) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-6-ethyl-11-isobutyl-5,12,15,19,33,36-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1024) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-18-isopropyl-5,6,11,12,16,19,33,36-octamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1025) (8R,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-8-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1026) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-9-(isopentyloxymethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1027) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-35-propyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1029) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1030) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1031) (3S,9S,18S,21S,25R,28S,31S,34S)-31-benzyl-9-(cyclohexylmethyl)-28-isobutyl-7,10,13,16,21,22,25,29,32-nonamethyl-8-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1032) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21,25-diisobutyl-28-isopropyl-7,10,13,16,22,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1033) (3S,9S,18S,21S,25R,28S,34S)-13-butyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,16,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1034) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,16,19,21,21,22,33,36-undecamethyl-15-(piperidine-1-carbonyl)tetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (1035) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methy]-6-[(2-fluorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-1[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1036) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-cyclobutyl-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1037) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-(methoxymethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1038) (3S,9S,18S,21S,25R,28S,31R,34S)-31-allyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29,31-nonamethyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1039) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1040) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1041) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-1[(1R)-1-hydroxyethyl]-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1042) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isopentyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1043) (3S,9S,12S,18S,27S,30S,34S)-12-benzyl-9-butyl-18-[(4-chlorophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1044) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-6-[(3-chlorophenyl)methyl]-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1045) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-ethyl-29-isobutyl-8,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1046) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-11-isobutyl-5,6,12,15,16,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1047) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-cyclobutyl-18-cyclopentyl-16-ethyl-11-isobutyl-5,6,12,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1048) (3S,9S,18S,21S,25S,28S,31S,34S)-31-benzyl-9-[(4-chlorophenyl)methyl]-28-isobutyl-7,10,13,16,21,22,29,32-octamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1049) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1050) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(cyclohexylmethyl)-12′-isobutyl-19′-isopropyl-7′,13′,16′,20′,34′,37′-hexamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1051) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-22-ethyl-28-isopropyl-7,10,13,16,21,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1052) (3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methy]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-6-[[3-(trifluoromethyl)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1053) (5S,8S,11S,15S,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-25-phenyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1054) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,30-diisobutyl-9-isopropyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1055) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[2-(p-tolyl)ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1056) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(cyclohexylmethyl)-19′-isopropyl-7′,12′,13′,16′,20′,34′,37′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1057) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopentylmethyl)-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1058) (6S,9S,13S,16S,19S,22S,25S,31S,34S)-19-benzyl-22-butyl-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-31-1[(4-methoxyphenyl)methyl]-4,10,14,19,20,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1059) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-N,N,5,12,16,19,33,36-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxo-11-pentyltetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1060) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(4-fluorobenzyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1061) (3S,9S,18S,21S,25S,28S,34S)-9-[(4-chlorophenyl)methyl]-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1062) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-25,25-difluoro-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1063) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[(4-chlorophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1064) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-18-cyclopentyl-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1065) (3S,6R,9S,18S,21S,25R,28S,34S)-9-[(4-chlorophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1066) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-35-isopropyl-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1067) (3S,9S,12S,18S,27S,30S,34R)-18-[(1R)-1-benzyloxyethyl]-3,9-diisobutyl-4,6,6,10,16,19,22,25,30,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1068) (3S,9S,18S,21S,25R,28S,31S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21,31-diisobutyl-28-isopropyl-7,10,13,16,22,25,26,29,31-nonamethyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1069) (8S,11S,17S,26S,29S,33R,36S)-17-[(4-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-8-isobutyl-29,36-diisopropyl-9,15,18,21,24,30,33,37-octamethyl-26-[(1S)-1-methylpropyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1070) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1071) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-22-(3-pyridylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1072) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-9-[(1R)-1-methoxyethyl]-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1073) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1074) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18,28-bis[(1 S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1075) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-9-[(3,4-difluorophenyl)methyl]-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1076) (3S,9S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-3,9,30-triisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1077) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-cyclopentyl-36′-(2-fluorobenzyl)-7′,12′,13′,16′,20′,34′,37′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1078) (3S,6S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-30-isobutyl-3,6-diisopropyl-1,4,10,16,19,22,25,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1079) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-3-isopropyl-4,7,10,16,19,22,25,30,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1080) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1081) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(3,3-difluoro-1-piperidyl)ethyl]-9-isobutyl-N,N,3,4,10,14,17,19,23,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (1082) (6S,9S,13R,16S,21aS,27S,33S,35aS,39aS)-6-((S)-sec-butyl)-27-(3-chloro-4-(trifluoromethyl)phenethyl)-33-(cyclohexylmethyl)-9-isobutyl-16-isopropyl-10,13,17,31,34-pentamethyldocosahydro-1H,26H-spiro[azeto[1,2-j]dipyrrolo[1,2-g:1′,2′-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-19,1′-cyclopentan]-5,8,11,15,18,21,26,29,32,35,39(12H,20H,35aH,39aH)-undecaone,   (1083) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-cyclopentyl-7′,12′,13′,16′,20′,34′,37′-heptamethyl-36′-(3-methylbenzyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1084) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-9,30-diisobutyl-3-isopropyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1085) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,16,19,22,25,30,31-heptamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1086) (3S,9S,18S,21S,28S,31S,34S)-31-benzyl-9-[(4-chlorophenyl)methyl]-28-isobutyl-7,10,13,16,21,22,29,32-octamethyl-8-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1087) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-8-[(5-methyl-3-pyridyl)methyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1088) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]-9-(m-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1089) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.4.0]octatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33,36-dodecone,   (1090) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-28-isobutyl-7,10,13,16,21,22,25,29-octamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1091) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1092) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-9-(5,5-difluoropentyl)-3-isobutyl-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1093) (3S,9S,18S,21S,25S,28S,34R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[36-thia-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1094) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(2-methylsulfonylethyl)-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1095) (3S,9S,12S,18S,27S,30S,34R)-18-(cyclohexylmethyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-6,6,7,16,19,22,25,31-octamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazabicyclo[32.4.0]octatriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1096) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,26′R,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-cyclohexyl-36′-(cyclohexylmethyl)-12′-isobutyl-7′,13′,17′,20′,34′,37′-hexamethyl-26′-phenyl-16′-(piperidine-1-carbonyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1097) (6&#39;S,12&#39;S,21&#39;S,23a&#39;S,31′R,34&#39;S,39a&#39;S)-21′-((S)-sec-butyl)-12′-(cyclohexylmethyl)-34′-isobutyl-10′,13′,16′,19′,31′,35′-hexamethyl-6′-(4-(trifluoromethyl)phenethyl)tetracosahydrospiro[cyclopentane-1,37′-pyrido[1,2-a]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,23′,29′,33′,36′,39′(23a′H,30′H,38′H)-undecaone,   (1098) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-35-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1099) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18,35-dicyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1100) (3S,9S,12S,18S,27S,30S,34S)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-9-[(2-methoxyphenyl)methyl]-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1101) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-[(1R)-1-methoxyethyl]-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1102) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-(cyclopropoxymethyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1103) (5S,8S,11S,15S,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,16,19,32,33,36-nonamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1104) (3S,6S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-9-[2-(3,3-difluoroazetidin-1-yl)ethyl]-3-isopropyl-1,4,10,16,19,22,25,30,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-6-(2,2,2-trifluoroethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1105) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-3-isopropyl-4,7,10,16,19,22,25,30,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1106) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1107) (8S,11S,17S,26S,29S,33R,36S)-17-[(4-chlorophenyl)methyl]-8,36-diisobutyl-29-isopropyl-9,15,18,21,24,30,33,37-octamethyl-26-[(1S)-1-methylpropyl]-11-[2-[4-(trifluoromethyl)phenyl]ethyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1108) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(3,3-difluoroazetidin-1-yl)-2-oxo-ethyl]-9-isobutyl-19-(methoxymethyl)-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (1109) (3S,9S,18S,21S,25S,28S,31S,34S)-31-allyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29,31-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1110) (4R,7S,10S,13S,16S,22S,31S,34S)-10-benzyl-22-[(4-chlorophenyl)methyl]-13-isobutyl-7-isopropyl-4,8,11,14,20,23,26,29-octamethyl-31-[(1S)-1-methylpropyl]-16-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,5,8,11,14,17,20,23,26,29,32-undecazabicyclo[32.4.0]octatriacontane-2,6,9,12,15,18,21,24,27,30,33-undecone,   (1111) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopropane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1112) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8,18-di((S)-sec-butyl)-35-(cyclohexylmethyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1113) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-propyl-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1114) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-(cyclobutylmethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1115) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-(isopentyloxymethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1116) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1117) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-N,N,5,12,16,19,33,36-octamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxo-11-pentyltetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1118) (7&#39;S,16&#39;S,19&#39;S,23&#39;S,26&#39;S,31a&#39;S,37&#39;S,39a′R)-16′-((S)-sec-butyl)-37′-(3-chloro-4-(trifluoromethyl)phenethyl)-7′-(cyclohexylmethyl)-26′-isopropyl-8′,11′,14′,19′,20′,24′,27′-heptamethyl-23′-(piperidine-1-carbonyl)tetracosahydro-2′H,6′H-spiro[cyclopentane-1,29′-pyrido[2,1-o]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-6′,9′,12′,15′,18′,21′,25′,28′,31′,36′,39′(22′H,30′H)-undecaone,   (1119) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-18-[(4-chlorophenyl)methyl]-3-isobutyl-9-(isopentyloxymethyl)-4,7,16,19,22,25,30,31-octamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1120) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-33-ethyl-11-isobutyl-N,N,5,6,12,16,19,36-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1121) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(cyclohexylmethyl)-19′-isopropyl-7′,12′,13′,17′,20′,34′,37′-heptamethyl-16′-(piperidine-1-carbonyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1122) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-((2-hydroxy-2-methylpropoxy)methyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1123) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-(5,5-difluoropentyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1124) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclobutylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1125) (8S,11S,17S,26S,29S,33S,36S)-8-benzyl-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-isopropyl-15,18,21,24,29,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1126) (1R,4S,7S,16S,22S,25S,31S,34R)-16-[(4-chlorophenyl)methyl]-25,31-diisobutyl-4-isopropyl-9,12,15,18,24,30-hexamethyl-7-[(1S)-1-methylpropyl]-22-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[3,6,9,12,15,18,21,24,27,30,33-undecazabicyclo[32.4.0]octatriacontane-28,1′-cyclopentane]-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1127) (3S,9S,12S,18S,27S,30S,34S)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-I[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-18-(p-tolylmethyl)-9-[[2-(trifluoromethyl)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1128) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclobutyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1129) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-22-[[2-(trifluoromethoxy)phenyl]methyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1130) (3S,9S,18S,21S,25S,28S,31R,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-31-ethyl-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29,31-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1131) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxo-22-propylhexatriacontahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-15-carboxamide,   (1132) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-11-propyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1133) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-27-cyclohexyl-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1134) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-(3-methylbut-2-enyl)-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1135) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[2-(3,3-difluoro-1-piperidyl)ethyl]-9-isobutyl-N,N,3,4,10,14,17,19,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (1136) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(3,3,4,4-tetrafluoropyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1137) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,12,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1138) (3S,9S,18S,21S,25S,28S,31R,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-31-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1139) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1140) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-12-ethyl-11-isobutyl-5,16,19,33,36-pentamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1141) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-(cyclopentylmethyl)-N,N,5,12,16,19,33,36-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1142) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-33-ethyl-11-isobutyl-5,6,12,16,19,36-hexamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1143) (5S,8S,11S,15S,18S,23aS,25R,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1144) (3S,9S,18S,21S,25S,28S,34S,36R)-21-cyclobutyl-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1145) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-11-(cyclopentylmethyl)-5,12,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1146) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-12-ethyl-11-isobutyl-5,16,19,33,36-pentamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1148) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-12-ethyl-11-isobutyl-N,N,5,6,16,19,33,36-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1149) (3S,9S,18S,21S,25S,28S,34S,36R)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1150) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-25-(3,3-dimethylpyrrolidine-1-carbonyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-I[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1151) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-33-ethyl-11-isobutyl-5,6,12,16,19,36-hexamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1152) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-36-ethyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1153) (3S,6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclopentyl-9-isobutyl-3,4,10,13,17,22,23,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1154) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isopentyl-5,6,12,16,19,33,36-heptamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1155) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(2-bromo-5-iodo-phenyl)methyl]-22-butyl-9-ethyl-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1156) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-butyl-25-[(3-chloro-5-iodo-phenyl)methyl]-9-ethyl-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1157) (3S,9S,18S,21S,25S,28S,31S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-31-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1158) (5S,8S,11S,15S,18S,23aS,25R,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-25-ethoxy-11-isobutyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1159) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-33-ethyl-11-isobutyl-5,6,12,16,19,36-hexamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1160) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1161) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,19,33,36-hexamethyl-15-(4-methylpiperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1162) (3S,9S,18S,21S,25S,28S,34S,36R)-9-(cyclohexylmethyl)-28-cyclopentyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1163) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36,36-difluoro-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1164) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,12,16,19,33,36-octamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1165) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1166) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-28-cyclopentyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1167) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-12-ethyl-11-isobutyl-5,16,19,33,36-pentamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1168) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,29-hexamethyl-18,28-bis[(1S)-1-methylpropyl]-25-(3,3,4,4-tetrafluoropyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1169) (3S,9S,12S,18S,27S,30S,34S)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-18-[(4-methoxyphenyl)methyl]-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-9-prop-2-ynyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1170) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1171) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isopentyl-5,12,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1172) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,29-hexamethyl-25-(4-methylpiperidine-1-carbonyl)-18,28-bis[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1173) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-11-(cyclopentylmethyl)-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1174) (5S,8S,11S,15S,18S,21R,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,21,33,36-octamethyl-15-(piperidine-1-carbonyl)tetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (1175) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-5,6,12,16,19,33-hexamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1176) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-(cyclopentylmethyl)-5,12,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1177) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(5-bromo-2-fluoro-phenyl)methyl]-22-butyl-9-ethyl-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1178) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1179) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36,36-difluoro-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1180) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(oxazolidine-3-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1181) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(4-(oxetan-3-yl)piperazine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1182) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-21-(2,2,2-trifluoroethyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1183) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-(cyclopentylmethyl)-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1184) (3S,9S,12S,18S,27S,30S,34S)-18-benzyl-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-1[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-9-prop-2-ynyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1185) (6&#39;S,12&#39;S,21&#39;S,24&#39;S,27a′R,33&#39;S,38a&#39;S)-21′-((S)-sec-butyl)-6′-(3-chloro-4-(trifluoromethyl)phenethyl)-33′-cyclohexyl-12′-(cyclohexylmethyl)-24′-isobutyl-10′,13′,16′,19′,25′,34′-hexamethyltetracosahydro-5′H-spiro[cyclopentane-1,36′-dipyrrolo[1,2-e1:1′,2′-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,23′,26′,32′,35′,38′(27′H,37′H)-undecaone,   (1186) (3S,9S,12S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,12,13,16,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1187) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-butyl-25-[(2,6-difluorophenyl)methyl]-9-ethyl-16-isobutyl-31-I[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1188) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,19,33,36-hexamethyl-15-(oxazolidine-3-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1189) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-22-ethyl-21-isobutyl-7,10,13,16,26,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1190) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-12-ethyl-11-isobutyl-5,6,16,19,33,36-hexamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1191) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,29-hexamethyl-18,28-bis[(1S)-1-methylpropyl]-25-[4-(oxetan-3-yl)piperazine-1-carbonyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1192) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1193) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-12-ethyl-11-isobutyl-5,6,16,19,33,36-hexamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1194) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36,36-difluoro-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1195) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(5-bromo-2-methyl-phenyl)methyl]-22-butyl-9-ethyl-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1196) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1197) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1198) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-12-ethyl-11-isobutyl-5,6,16,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1199) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-(cyclopentylmethyl)-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1200) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1201) (5S,8S,11S,15S,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1202) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,12,16,19,22,25,31-decamethyl-27-I[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1203) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7-ethyl-21-isobutyl-10,13,16,22,26,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1204) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-9-(cyclohexylmethyl)-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1205) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-33-ethyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,36-octamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1206) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-21-(2,2,2-trifluoroethyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1207) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3,3,4,4-tetrafluoropyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1208) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-12-ethyl-11-isobutyl-5,6,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1209) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-5,6,12,16,19,33-hexamethyl-35-(4-methylbenzyl)-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1210) (5S,8S,11S,15S,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1211) (5S,8S,11S,15S,18S,21S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,21,33,36-octamethyl-15-(piperidine-1-carbonyl)tetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (1212) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(5-bromo-2-chloro-phenyl)methyl]-22-butyl-9-ethyl-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1213) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,33,36-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1214) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1215) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-5,6,12,16,19,33-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1216) (3S,9S,12S,18S,27S,30S,34S)-12-[(5-bromo-2-thienyl)methyl]-9-butyl-18-[(4-chlorophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1217) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-N,N,5,6,12,16,19,33-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1218) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-33-ethyl-11-isobutyl-5,6,12,15,19,36-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1219) (3S,9S,12S,18S,27S,30S,34S)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-9-prop-2-ynyl-18-[[4-(trifluoromethoxy)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1220) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-12-ethyl-11-isobutyl-5,6,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1221) (5S,8S,11S,15R,18S,21S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,19,21,33,36-octamethyl-35-(4-methylbenzyl)tetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (1222) (5S,8S,11S,15R,18S,21R,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,19,21,33,36-octamethyl-35-(4-methylbenzyl)tetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (1223) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-11-isopentyl-5,12,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1224) (3S,9S,18S,21S,25S,28S,34S,36R)-28-cyclohexyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1225) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,8,12,15,19,33,36-octamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1226) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-butyl-9-ethyl-25-[(3-fluoro-5-iodo-phenyl)methyl]-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1227) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-13-ethyl-21-isobutyl-7,10,16,22,26,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1228) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1229) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-25-(3,3,4,4,5,5-hexafluoropiperidine-1-carbonyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1230) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-31-[(4-fluorophenyl)methyl]-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-prop-2-ynyl-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1231) (5S,8S,11S,15S,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-25-ethoxy-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1232) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1233) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-12-ethyl-11-isobutyl-5,16,19,33,36-pentamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1234) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-12-ethyl-11-isobutyl-5,6,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1235) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1236) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-36-ethyl-11-isobutyl-5,6,12,16,19,33-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1237) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-11-isopentyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1238) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-15-(1,1-dioxidothiomorpholine-4-carbonyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1239) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,18,19,33,36-octamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1240) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(5-bromo-3-pyridyl)methyl]-22-butyl-9-ethyl-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1241) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-ethoxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1242) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25,25-difluoro-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1243) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-9-isobutyl-16-isopropyl-3,4,10,14,17,22,23,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1244) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1245) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1246) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-31-[(4-methoxyphenyl)methyl]-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-prop-2-ynyl-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1247) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,29-hexamethyl-18,28-bis[(1S)-1-methylpropyl]-25-(oxazolidine-3-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1248) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25,25-difluoro-11-isobutyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1249) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-butyl-9-ethyl-25-[(2-fluoro-3-iodo-phenyl)methyl]-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1250) (5S,8S,11S,15S,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1251) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-(cyclopentylmethyl)-5,6,12,16,19,33,36-heptamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1252) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-12-ethyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,16,19,33,36-heptamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1253) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1254) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25,25-difluoro-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1255) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-16-ethyl-21-isobutyl-7,10,13,22,26,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1256) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-butyl-25-[(2,3-difluorophenyl)methyl]-9-ethyl-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-1[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1257) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,29-hexamethyl-18,28-bis[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1258) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-prop-2-ynyl-31-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1259) (5S,8S,11S,15S,18S,23aS,25R,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-25-ethoxy-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1260) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-21-(2,2,2-trifluoroethyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1261) (5S,8S,11S,15S,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1262) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-12-ethyl-11-isobutyl-5,16,19,33,36-pentamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1263) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-25-(1,1-dioxo-1,4-thiazinane-4-carbonyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1264) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-25,25-difluoro-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1265) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-25-(3,3,4,4,5,5-hexafluoropiperidine-1-carbonyl)-21-isobutyl-7,10,13,16,22,29-hexamethyl-18,28-bis[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1266) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-12-ethyl-11-isobutyl-5,16,19,33,36-pentamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1267) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1268) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-butyl-25-[(2,5-difluorophenyl)methyl]-9-ethyl-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1269) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-(cyclopentylmethyl)-N,N,5,12,16,19,33,36-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1270) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-36,36-difluoro-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1271) (3S,9S,18S,21S,25S,28S,34S,36R)-28-cyclohexyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1272) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-33-ethyl-11-isobutyl-5,6,12,16,19,36-hexamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1273) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-25-(3,3-dimethylpyrrolidine-1-carbonyl)-21-isobutyl-7,10,13,16,22,29-hexamethyl-18,28-bis[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1274) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1275) (3S,9S,18S,21S,25S,28S,34S)-21-cyclobutyl-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1276) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-33-ethyl-11-isobutyl-18-isopropyl-5,6,12,16,19,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1277) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,29-hexamethyl-18,28-bis[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1278) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1279) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-25-(1,1-dioxo-1,4-thiazinane-4-carbonyl)-21-isobutyl-7,10,13,16,22,29-hexamethyl-18,28-bis[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1280) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-15-(3,3-dimethylpyrrolidine-1-carbonyl)-11-isobutyl-18-isopropyl-5,6,12,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1281) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1282) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-12-ethyl-11-isobutyl-N,N,5,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1283) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(azetidine-1-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-25,25-difluoro-11-isobutyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1284) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-[4-(oxetan-3-yl)piperazine-1-carbonyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1285) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1286) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(2-fluoro-5-iodo-phenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1287) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-12-ethyl-11-isobutyl-N,N,5,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1288) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-prop-2-ynyl-31-[[4-(trifluoromethoxy)phenyl]methyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1289) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isopentyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1290) (3S,9S,18S,21S,25S,28S,34S,36R)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1291) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(4-methylpiperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1292) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isopentyl-N,N,5,12,16,19,33,36-octamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1293) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,12,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1294) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,19,33,36-hexamethyl-15-(4-(oxetan-3-yl)piperazine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1295) (3S,9S,18S,21S,25S,28S,34S)-21-cyclobutyl-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1296) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1297) (3S,9S,18S,21S,25S,28S,34S,36R)-28-cyclohexyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-21-(2,2,2-trifluoroethyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1298) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-prop-2-ynyl-31-[[4-(trifluoromethoxy)phenyl]methyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1299) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,12,16,19,33,36-hexamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1300) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,19,33,35,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1301) (3S,9S,18S,21S,25S,28S,34S,36R)-28-cyclohexyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1302) (3S,9S,18S,21S,25S,28S,31S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-31-ethyl-21-isobutyl-7,10,13,16,22,26,29,31-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1303) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1304) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-bromo-2-fluoro-phenyl)methyl]-22-butyl-9-ethyl-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1305) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(4-fluorophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1306) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1307) (3S,6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclopentyl-9-isobutyl-3,4,10,13,17,22,29,32-octamethyl-6-[(1S)-1-methylpropyl]-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1308) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1309) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18,35-dicyclopentyl-11-isobutyl-5,12,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1310) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isopentyl-5,12,16,19,33,36-hexamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1311) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25,25-difluoro-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1312) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-5,6,12,16,19,33-hexamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1313) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-31-benzyl-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-prop-2-ynyl-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1314) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-9-isobutyl-16-isopropyl-3,4,10,14,17,22,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1315) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,22,26,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1316) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-9-isobutyl-16-isopropyl-3,4,10,14,17,22,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1317) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1318) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(5-chloro-2-thienyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1319) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-5,6,12,16,19,33-hexamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1320) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-(cyclopentylmethyl)-5,12,16,19,33,36-hexamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1321) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1322) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-5,6,12,16,19,33-hexamethyl-35-(4-methylbenzyl)-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1323) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-15-(3,3-dimethylpyrrolidine-1-carbonyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1324) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-12-ethyl-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,16,19,33,36-octamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1325) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-5,6,12,16,19,33-hexamethyl-35-(4-methylbenzyl)-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1326) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isopentyl-5,12,16,19,33,36-hexamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1327) (3S,9S,12S,18S,27S,30S,34S)-18-[(4-fluorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-9-prop-2-ynyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1328) (3S,6S,9S,13R,16S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclopentyl-9-isobutyl-3,4,10,13,17,22,29,32-octamethyl-6-[(1S)-1-methylpropyl]-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1329) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(oxazolidine-3-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1330) (5S,8S,11S,15S,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1331) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,12,15,19,33,36-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1332) (5S,8S,11S,14aR,20S,25aS,31S,37S,39aS)-8-((S)-sec-butyl)-31-(3-chloro-4-(trifluoromethyl)phenethyl)-37-(cyclohexylmethyl)-11-isobutyl-20-isopropyl-5,6,12,21,35,38-hexamethyltetracosahydro-2H,4H-spiro[azeto[1,2-j]dipyrrolo[1,2-e1:1′,2′-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-23,1′-cyclopentan]-4,7,10,13,19,22,25,30,33,36,39(14H,24H)-undecaone,   (1333) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1334) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1335) (5S,8S,11S,15S,18S,23aS,25R,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-25-ethoxy-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1336) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18,35-dicyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1337) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36,36-difluoro-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1338) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-33-ethyl-11-isobutyl-5,6,12,16,19,36-hexamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1339) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1340) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-(cyclopentylmethyl)-29-(3-fluoro-4-(trifluoromethyl)phenethyl)-N,N,5,12,16,19,33,36-octamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1341) (3S,9S,18S,21S,25S,28S,34S,36R)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1342) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-28-cyclopentyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1343) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1344) (6S,9S,13S,16S,22S,25S,31S,34S)-31-[(4-fluorophenyl)methyl]-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-prop-2-ynyl-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1345) (3S,9S,15S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,15,16,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1346) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25,25-difluoro-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1347) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(4-methylpiperidine-1-carbonyl)-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1348) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-25,25-difluoro-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1349) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-15-(1,1-dioxidothiomorpholine-4-carbonyl)-11-isobutyl-18-isopropyl-5,6,12,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1350) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-prop-2-ynyl-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1351) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-5,6,12,16,19,33-hexamethyl-35-(4-methylbenzyl)-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1352) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-12-[(2-chloro-5-iodo-phenyl)methyl]-18-[(4-chlorophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1353) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1354) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26-hexamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1355) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1356) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isopentyl-5,12,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1357) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1358) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-butyl-9-ethyl-25-[(5-iodo-2-methyl-phenyl)methyl]-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1359) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-(cyclopentylmethyl)-5,12,16,19,33,36-hexamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1360) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,12,16,19,33,36-hexamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1361) (3S,9S,12S,18S,27S,30S,34S)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-9-prop-2-ynyl-18-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1362) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1363) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-cyclobutyl-28-cyclohexyl-9-(cyclohexylmethyl)-36,36-difluoro-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1364) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-5,6,12,16,19,33-hexamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1365) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-12-ethyl-11-isobutyl-N,N,5,6,16,19,33,36-octamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1366) (3S,9S,18S,21S,25S,28S,34S,36R)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1367) (3S,9S,18S,21S,25S,28S,34S,36R)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1368) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-36-ethyl-11-isobutyl-5,6,12,16,19,33-hexamethyl-35-(4-methylbenzyl)-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1369) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-ethoxy-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1370) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-36-ethoxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1371) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-(cyclopentylmethyl)-5,12,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1372) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-bromo-5-fluoro-phenyl)methyl]-22-butyl-9-ethyl-16-isobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1373) (3S,9S,18S,21S,25R,28S,31S,34S,36S)-31-benzyl-9-[(4-chlorophenyl)methyl]-36-hydroxy-28-isobutyl-7,10,13,16,21,22,25,29,32-nonamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1374) (3S,9S,18S,21S,25S,28S,34S,36S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-hydroxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1375) (3S,9S,18S,21S,25R,28S,31S,34S,36R)-31-benzyl-9-[(4-chlorophenyl)methyl]-36-hydroxy-28-isobutyl-7,10,13,16,21,22,25,29,32-nonamethyl-18-[(1S)-1-methylpropyl]-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1376) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-hydroxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1377) (6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16,22-diisobutyl-4,9,10,13,14,19,19,20,29,32-decamethyl-6-[(1S)-1-methylpropyl]-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1378) (6S,9S,13R,16S,22S,25S,28R,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16,22-diisobutyl-4,9,10,13,14,19,19,20,28,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1379) (3S,6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9,16,22-triisobutyl-3,4,10,13,14,19,19,20,29,32-decamethyl-6-[(1S)-1-methylpropyl]-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1380) (3S,9S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-3,9-diisobutyl-1,6,6,7,16,19,22,25,30,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1381) (3S,9S,12S,15R,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,9-diisobutyl-1,6,6,7,15,16,19,22,25,30,31,34-dodecamethyl-27-[(1S)-1-methylpropyl]-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   1382) (6S,9S,13R,16S,22S,25S,28R,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16,22-diisobutyl-4,9,10,13,14,19,19,20,28,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1383) (6S,9S,13R,16S,22S,25S,28R,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16,22-diisobutyl-4,9,10,13,14,19,19,20,28,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-31-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1384) (3S,9S,12S,15R,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-1,6,6,7,15,16,19,22,25,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1385) (3S,9S,12S,15R,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,9-diisobutyl-1,6,6,7,15,16,19,22,25,30,31,34-dodecamethyl-27-[(1S)-1-methylpropyl]-18-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1386) (6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9,16,22-triisobutyl-4,10,13,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1387) (6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16,22-diisobutyl-4,9,10,13,14,19,19,20,29,32-decamethyl-6-[(1S)-1-methylpropyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1388) (3S,9S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1389) (3S,9S,12S,15R,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-3,9,30-triisobutyl-1,6,6,7,15,16,19,22,25,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1390) (3S,9S,12S,15R,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclohexylmethyl)-3,9-diisobutyl-1,6,6,7,15,16,19,22,25,30,31,34-dodecamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1391) (3S,6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16,22-diisobutyl-3,4,9,10,13,14,19,19,20,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1392) (6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16,22-diisobutyl-4,9,10,13,14,19,19,20,29,32-decamethyl-6-[(1S)-1-methylpropyl]-31-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1393) (3S,9S,12S,15R,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-1,6,6,7,15,16,19,22,25,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-18-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1394) (6S,9S,13R,16S,22S,25S,28R,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9,16,22-triisobutyl-4,10,13,14,19,19,20,28,29,32-decamethyl-6-[(1S)-1-methylpropyl]-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1395) (6S,9S,13R,16S,22S,25S,28R,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9,16,22-triisobutyl-4,10,13,14,19,19,20,28,29,32-decamethyl-6-[(1S)-1-methylpropyl]-31-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1396) (3S,9S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-18-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1397) (3S,9S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,9-diisobutyl-1,6,6,7,16,19,22,25,30,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-18-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1398) (3S,9S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,9-diisobutyl-1,6,6,7,16,19,22,25,30,31,34-undecamethyl-27-[(1S)-1-methylpropyl]-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1399) (3S,6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16,22-diisobutyl-3,4,9,10,13,14,19,19,20,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-31-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1400) (6S,9S,13R,16S,22S,25S,28R,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-9,16,22-triisobutyl-4,10,13,14,19,19,20,28,29,32-decamethyl-6-[(1S)-1-methylpropyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1401) (3S,6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9,16,22-triisobutyl-3,4,10,13,14,19,19,20,29,32-decamethyl-6-[(1S)-1-methylpropyl]-31-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1402) (3S,6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16,22-diisobutyl-3,4,9,10,13,14,19,19,20,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1403) (6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9,16,22-triisobutyl-4,10,13,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-31-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1404) (3S,9S,12S,18S,27S,30S,34S)-12-[(3-bromophenyl)methyl]-9-butyl-18-[(4-chlorophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1405) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-31-(cyclopentylmethyl)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-22-(2-methylallyl)-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1406) (3S,9S,12S,18S,27S,30S,34R)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-9-prop-2-ynyl-18-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1407) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-12-[(3-chlorophenyl)methyl]-18-[(4-chlorophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1408) (6S,9S,13R,16S,22S,25S,31S,34S)-31-[(4-chlorophenyl)methyl]-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,13,14,19,19,20,29,32-nonamethyl-22-(3-methylbut-2-enyl)-6-[(1S)-1-methylpropyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1409) (3S,9S,12S,18S,27S,30S,34S)-3-benzyl-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-30-isobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-I[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1410) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-30-isobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-I[(1S)-1-methylpropyl]-3-propyl-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1411) (1S,7S,10S,14S,17S,26S,32S)-32-[(3-iodophenyl)methyl]-7,14-diisobutyl-3,4,4,9,13,19,22,25,28-nonamethyl-17-I[(1S)-1-methylpropyl]-10-(piperidine-1-carbonyl)-3,6,9,13,16,19,22,25,28,31,34-undecazabicyclo[24.8.6]tetracontane-2,5,8,12,15,18,21,24,27,30,33-undecone,   (1412) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-3,30-diisobutyl-12-[(3-methoxyphenyl)methyl]-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1413) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-butyl-31-(cyclobutylmethyl)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1414) (6S,9S,13S,16S,22S,25S,31S,34S)-31-[(4-chlorophenyl)methyl]-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-22-(2-methylallyl)-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1415) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-bromophenyl)methyl]-22-butyl-31-[(4-chlorophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1416) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-(cyclohexylmethyl)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1417) (6S,9S,13S,16S,22S,25S,31S,34S)-22-butyl-9-hexyl-25-[(3-iodophenyl)methyl]-16-isobutyl-31-[(4-methoxyphenyl)methyl]-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1418) (3S,9S,12S,18S,27S,30S,34R)-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31,34-decamethyl-9-(3-methylbut-2-enyl)-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1419) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-31-[(4-chlorophenyl)methyl]-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-22-(3-methylbut-2-enyl)-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1420) (6S,9S,13S,16S,22S,25S,31S,34S)-22-butyl-31-(cyclohexylmethyl)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1421) (3S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-9-(2-methylallyl)-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1422) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-3-(cyclobutylmethyl)-12-[(3-iodophenyl)methyl]-30-isobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1423) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-(cyclopentylmethyl)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1424) (2aS,5S,11S,14S,20S,23S,30aS,33S,36S)-33-((S)-sec-butyl)-14-butyl-5-(cyclopentylmethyl)-11-(3-iodobenzyl)-20-isobutyl-4,7,16,17,17,22,35,36-octamethyl-23-(piperidine-1-carbonyl)tetracosahydroazeto[1,2-j]pyrido[1,2-a][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-3,6,9,12,15,18,21,25,31,34,37(1H,22H,27H)-undecaone,   (1425) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-prop-2-ynyl-31-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1426) (3S,9S,12S,18S,27S,30S,34S)-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-9-prop-2-ynyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1427) (6S,9S,13R,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,13,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-22-prop-2-ynyl-31-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1428) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-31-[(4-chlorophenyl)methyl]-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-22-prop-2-ynyl-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1429) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-31-[(4-chlorophenyl)methyl]-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-22-(2-methylallyl)-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1430) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-30-isobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-I[(1S)-1-methylpropyl]-3-(2-phenylethyl)-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1431) (3S,9S,12S,18S,27S,30S,34S)-9-allyl-8-[(4-chlorophenyl)methyl]-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1432) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-butyl-31-(cyclopentylmethyl)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-3,4,10,14,19,19,20,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1433) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-12-[(3-iodophenyl)methyl]-30-isobutyl-3-isopentyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-18-[[4-(trifluoromethyl)phenyl]methyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1434) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-22-benzyl-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1435) (8R,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-8-ethyl-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1436) (8R,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-8-(isopentyloxymethyl)-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1437) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-9-isobutyl-22-(isopentyloxymethyl)-16-isopropyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1438) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-22-ethyl-9-isobutyl-16-isopropyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1439) (8R,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-cyclopentyl-8-ethyl-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1440) (8R,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-cyclopentyl-29-isobutyl-8-(isopentyloxymethyl)-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1441) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-ethyl-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1442) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-22-benzyl-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-9-isobutyl-16-isopropyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1443) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-22-(isopentyloxymethyl)-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1444) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-22-(hydroxymethyl)-9-isobutyl-16-isopropyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1445) (3S,9S,18S,21S,25S,28S,34R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[36-oxa-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.4.0]octatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1446) (8R,11S,17S,26S,29S,33S,36S)-8-benzyl-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-cyclopentyl-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1447) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-allyl-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-9-isobutyl-16-isopropyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1448) (8R,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-8-(hydroxymethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1449) (8S,11S,17S,26S,29S,33S,36S)-8-allyl-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1450) (3S,6S,9S,12S,18S,27S,30S,34S)-6-benzyl-27-cyclohexyl-18-(5,5-difluoropentyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-4,6,10,16,19,22,25,31-octamethyl-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1451) (3S,9S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(5,5-difluoropentyl)-3,9,30-triisobutyl-4,6,6,10,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1452) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21,28-diisobutyl-18-isopropyl-7,10,13,16,22,25,29-heptamethyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1453) (3S,9S,12S,18S,27S,30S,34S)-27-cyclohexyl-18-(5,5-difluoropentyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-4,6,6,10,16,19,22,25,31-nonamethyl-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1454) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1455) (3S,9S,12S,18S,27S,30S,34S)-18-(5,5-difluoropentyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-4,6,6,10,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1456) (3S,9S,12S,18S,27S,30S,34S)-18-(5,5-difluoropentyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-1,4,6,6,10,16,19,22,25,31-decamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1457) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1458) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-18-isopropyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1459) (3S,9S,15S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-15-ethyl-21-isobutyl-28-isopropyl-7,10,13,22,25,29-hexamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1460) (3S,9S,12S,18S,27S,30S,34R)-27-cyclohexyl-18-(5,5-difluoropentyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-4,6,6,10,16,19,22,25,31,34-decamethyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1461) (8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-6,11,12,15,19,32,33,36-octamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1462) (8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-6,11,12,15,19,33,36-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1463) (8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-6,11,12,15,19,33,36-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1464) (8S,11S,17S,26S,29S,33R,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-24-ethyl-8-[(2-hydroxy-2-methyl-propoxy)methyl]-29,36-diisobutyl-17-(isopentyloxymethyl)-9,15,18,21,30,33,37-heptamethyl-26-[(1S)-1-methylpropyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1465) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1466) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-7,10,13,16,21,22,25,29-octamethyl-18-I[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1467)N-tert-butyl-2-[[(3S,9S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,30-diisobutyl-18-(isopentyloxymethyl)-4,6,6,10,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-9-yl]methoxy]acetamide,   (1468) (8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-6,12,15,19,32,33,36-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1469) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-28-ethyl-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1470) (6&#39;S,15&#39;S,18&#39;S,22′R,25&#39;S,30a&#39;S,36&#39;S,38a′R)-15′-((S)-sec-butyl)-36′-(3-chloro-4-(trifluoromethyl)phenethyl)-25′-cyclopentyl-7′,10′,13′,18′,19′,22′,26′-heptamethyl-6′-(4-(trifluoromethyl)benzyl)tetracosahydro-5′H-spiro[cyclopentane-1,28′-dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,24′,27′,30′,35′,38′(21′H,29′H)-undecaone,   (1471) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1472) (6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-4-ethyl-22-[(2-hydroxy-2-methyl-propoxy)methyl]-9,16-diisobutyl-31-(isopentyloxymethyl)-10,13,17,19,19,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1473) (3S,9S,12S,18S,27S,30S,34R)-25-butyl-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(2-hydroxy-2-methyl-propoxy)methyl]-3,30-diisobutyl-18-(isopentyloxymethyl)-4,6,6,16,19,22,31,34-octamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1474) (3S,9S,12S,18S,27S,30S,34R)-18-(cyclohexylmethyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-4,6,6,10,16,19,22,25,31,34-decamethyl-27-prop-2-ynyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1475) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,19,33,36-heptamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1476) (3S,9S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-25-ethyl-30-[(2-hydroxy-2-methyl-propoxy)methyl]-3,9-diisobutyl-18-(isopentyloxymethyl)-4,6,6,10,16,19,22,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1477) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1478) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-7,10,13,16,21,22,25,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1479) (8S,11S,15R,18S,23aS,29S,31aR,37S,39aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-37-(cyclohexylmethyl)-18-cyclopentyl-6,11,12,15,19,38-hexamethyltetracosahydro-2H,4H-spiro[azeto[2,1-u]dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,36,39(14H,22H)-undecaone,   (1480)N-tert-butyl-2-[[(3S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,30-diisobutyl-18-(isopentyloxymethyl)-1,4,6,6,10,16,19,22,25,31-decamethyl-27-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-9-yl]methoxy]acetamide,   (1481) (8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-6,11,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1482) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,19,32,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1483) (3S,9S,18S,21S,25R,28S,34S,36R)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-36-hydroxy-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1484) (3S,9S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-ethyl-9-[(2-hydroxy-2-methyl-propoxy)methyl]-3,30-diisobutyl-18-(isopentyloxymethyl)-4,6,6,10,16,19,25,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1485) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-7,10,13,16,21,22,25,29-octamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1486) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-7,10,13,16,21,22,25,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1487) (6&#39;S,15&#39;S,18&#39;S,22′R,25&#39;S,30a&#39;S,36&#39;S,38a′R)-15′-((S)-sec-butyl)-36′-(3-chloro-4-(trifluoromethyl)phenethyl)-25′-cyclopentyl-18′-isobutyl-7′,10′,13′,19′,22′,26′-hexamethyl-6′-(4-methylbenzyl)tetracosahydro-5′H-spiro[cyclopentane-1,28′-dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,24′,27′,30′,35′,38′(21′H,29′H)-undecaone,   (1488) (8S,11S,15R,18S,23aS,29S,31aR,37S,39aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-6,12,15,19,38-pentamethyl-37-(4-methylbenzyl)tetracosahydro-2H,4H-spiro[azeto[2,1-u]dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,36,39(14H,22H)-undecaone,   (1489) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,29-hexamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1490) (3S,9S,18S,21S,25R,28S,34S)-18-butyl-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1491) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-5,6,11,12,15,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1492)N-tert-butyl-2-[[(8S,11S,17S,26S,29S,33R,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-29,36-diisobutyl-17-(isopentyloxymethyl)-9,15,18,21,24,30,33,37-octamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-8-yl]methoxy]acetamide,   (1493) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-18-isopropyl-7,10,13,16,22,25,29-heptamethyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1494) (8S,11S,15R,18S,23aS,29S,31aR,37S,39aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-6,11,12,15,19,38-hexamethyl-37-(4-methylbenzyl)tetracosahydro-2H,4H-spiro[azeto[2,1-u]dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,36,39(14H,22H)-undecaone,   (1495)N-tert-butyl-2-[[(2S,5S,14S,20S,23S,29S,32R)-20-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-7-ethyl-23,29-diisobutyl-14-(isopentyloxymethyl)-1,10,13,16,22,26,26,28,32-nonamethyl-5-[(1S)-1-methylpropyl]-3,6,9,12,15,18,21,24,27,30,34-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-2-yl]methoxy]acetamide,   (1496) (8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-6,12,15,19,33,36-hexamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1497) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-5,6,11,12,15,19,32,33,36-nonamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1498) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1499) (8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1500) (8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-6,12,15,19,33,36-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1501) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1502)N-tert-butyl-2-[[(3S,9S,12S,18S,27S,30S,34S)-3,30-diisobutyl-18-(isopentyloxymethyl)-1,4,6,6,10,16,19,22,25,31-decamethyl-27-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-34-(piperidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-9-yl]methoxy]acetamide,   (1503) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1504) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,19,32,33,36-octamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1505) (3S,9S,12S,18S,27S,30S,34R)-25-butyl-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(2-hydroxy-2-methyl-propoxy)methyl]-30-isobutyl-18-(isopentyloxymethyl)-3-isopropyl-4,6,6,10,16,19,22,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1506) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-7,10,13,16,21,22,25,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1507) (8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-6,11,12,15,19,32,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1508) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1509) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-36,36-difluoro-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1510) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1511) (3S,9S,12S,18S,27S,30S,34R)-18-(cyclohexylmethyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-27-isopropyl-4,6,6,10,16,19,22,25,31,34-decamethyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1512) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-5,6,11,12,15,19,33,36-octamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1513)N-tert-butyl-2-[[(6S,9S,13R,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-4-ethyl-9,16-diisobutyl-31-(isopentyloxymethyl)-10,13,17,19,19,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontan-22-yl]methoxy]acetamide,   (1514) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-5,6,11,12,15,19,33,36-octamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1515) (3S,9S,18S,21S,25R,28S,34S)-9-(5,5-difluoropentyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1516) (3S,9S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-ethyl-9-[(2-hydroxy-2-methyl-propoxy)methyl]-3,30-diisobutyl-18-(isopentyloxymethyl)-4,6,6,10,19,22,25,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1517) (8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-6,12,15,19,32,33,36-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1518) (3S,9S,18S,21S,25R,28S,34S)-28-butyl-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1519) (3S,9S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-25-ethyl-9-[(2-hydroxy-2-methyl-propoxy)methyl]-3,30-diisobutyl-18-(isopentyloxymethyl)-4,6,6,10,16,19,22,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1520) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1521) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-21-isobutyl-6,7,10,13,16,22,25,29-octamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1522) (8S,11S,15R,18S,23aS,29S,31aR,37S,39aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-6,11,12,15,19,38-hexamethyl-37-(4-(trifluoromethyl)benzyl)tetracosahydro-2H,4H-spiro[azeto[2,1-u]dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,36,39(14H,22H)-undecaone,   (1523) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-7,10,13,16,21,22,25,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1524) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1525) (6&#39;S,15&#39;S,18&#39;S,22′R,25&#39;S,30a&#39;S,36&#39;S,38a′R)-15′-((S)-sec-butyl)-36′-(3-chloro-4-(trifluoromethyl)phenethyl)-25′-cyclopentyl-7′,10′,13′,18′,19′,22′,26′-heptamethyl-6′-(4-methylbenzyl)tetracosahydro-5′H-spiro[cyclopentane-1,28′-dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,24′,27′,30′,35′,38′(21′H,29′H)-undecaone,   (1526) (3S,9S,12S,18S,27S,30S,34R)-18-(5,5-difluoropentyl)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9,30-triisobutyl-4,6,6,10,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1527) (3S,9S,18S,21S,25R,28S,34S)-18-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1528) (3S,9S,12S,18S,27S,30S,34S)-25-ethyl-9-[(2-hydroxy-2-methyl-propoxy)methyl]-3,30-diisobutyl-18-(isopentyloxymethyl)-1,4,6,6,10,16,19,22,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-12-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1529) (3S,9S,18S,21S,25R,28S,34S,36S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-36-hydroxy-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1530) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-21-isobutyl-6,7,10,13,16,22,25,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1531) (8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-6,12,15,19,32,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1532) (3S,9S,12S,18S,27S,30S,34S)-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-9-[(2-hydroxy-2-methyl-propoxy)methyl]-3,30-diisobutyl-18-(isopentyloxymethyl)-1,4,6,6,10,16,19,22,25,31-decamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1533) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-prop-2-ynyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1534) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1535) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1536) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-5,6,11,12,15,19,32,33,36-nonamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1537) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,19,33,36-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1538)N-tert-butyl-2-[[(2S,5S,14S,20S,23S,29S,32S)-2,23,29-triisobutyl-14-(isopentyloxymethyl)-1,7,10,13,16,22,26,26,28-nonamethyl-5-[(1S)-1-methylpropyl]-3,6,9,12,15,18,21,24,27,30,34-undecaoxo-20-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-32-yl]methoxy]acetamide,   (1539) (8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-6,11,12,15,19,32,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1540) (5S,8S,11S,15R,18S,23aS,29S,31aR,37S,39aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-5,6,11,12,15,19,38-heptamethyl-37-(4-methylbenzyl)tetracosahydro-2H,4H-spiro[azeto[2,1-u]dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,36,39(14H,22H)-undecaone,   (1541) (3S,9S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(2-hydroxy-2-methyl-propoxy)methyl]-3,30-diisobutyl-18-(isopentyloxymethyl)-1,4,6,6,10,16,19,22,25,31-decamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1542) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-21-isobutyl-6,7,10,13,16,22,25,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1543) (6&#39;S,15&#39;S,18&#39;S,22′R,25&#39;S,30a&#39;S,36&#39;S,38a′R)-15′-((S)-sec-butyl)-36′-(3-chloro-4-(trifluoromethyl)phenethyl)-6′-(cyclohexylmethyl)-25′-cyclopentyl-7′,10′,13′,18′,19′,22′,26′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,28′-dipyrrolo[2,1-i:2′,1′-o][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,17′,20′,24′,27′,30′,35′,38′(21′H,29′H)-undecaone,   (1544) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1545) (3S,9S,18S,21S,25R,28S,34S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1546) (3S,9S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(2-hydroxy-2-methyl-propoxy)methyl]-3,30-diisobutyl-18-(isopentyloxymethyl)-4,6,6,10,16,19,22,25,31,34-decamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (1547) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(m-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1548) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-5-butyl-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1549) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1550) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-(o-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1551) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-9-[(4-methoxyphenyl)methyl]-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1552) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-(cyclopentylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1553) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-cyclopropyl-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1554) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-5-cyclobutyl-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1555) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-[[3-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1556) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(3-fluorophenyl)methyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1557) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(3-fluorophenyl)methyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1558) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5,11-diisobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1559) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-6,11,12,16,19,33,36-heptamethyl-5-phenethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1560) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyl-5-propyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1561) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-5-benzyl-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1562) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,16,19,33,36-octamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1563) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethoxy)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1564) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,15,19,33,36-heptamethyl-11-propyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1565) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethoxy)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1566) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-(cyclopentylmethyl)-18-isopropyl-6,11,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1567) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[2-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1568) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-11-butyl-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1569) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-ethyl-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1570) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-(m-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1571) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(4-fluorophenyl)methyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1572) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[3-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1573) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-[[3-(trifluoromethoxy)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1574) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-5,35-bis(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1575) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-8-[(1S)-1-methylpropyl]-9-[[3-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1576) (3S,9S,18S,21S,25S,28S,34S)-9-[(4-bromophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1577) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5-isopentyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1578) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,15,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1579) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-[[2-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1580) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-5,35-bis(cyclohexylmethyl)-18-isopropyl-6,11,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1581) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-5,35-bis(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1582) (3S,9S,18S,21S,25R,28S,34S)-9-[(2-chlorophenoxy)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1583) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(2-fluorophenyl)methyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1584) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(o-tolylmethyl)-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1585) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(2-fluorophenyl)methyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1586) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-cyclopropyl-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1587) (3S,9S,18S,21S,25R,28S,34S)-9-[(3-bromophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1588) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-9-[(4-methoxyphenyl)methyl]-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1589) (3S,9S,18S,21S,25R,28S,34S)-9-[(2-chlorophenoxy)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1590) (3S,9S,18S,21S,25R,28S,34S)-9-[(4-bromophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1591) (3S,9S,18S,21S,25R,28S,34S)-9-[(2-chlorophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1592) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,18-diisopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1593) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-ethyl-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1594) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1595) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-isopentyl-18-isopropyl-6,11,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1596) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-5-butyl-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1597) (3S,9S,18S,21S,25R,28S,34S)-9-[(3-bromophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1598) (3S,9S,18S,21S,25S,28S,34S)-9-benzyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1599) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(2-fluorophenyl)methyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1600) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-5-cyclohexyl-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1601) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)-5-propyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1602) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(4-fluorophenyl)methyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1603) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-5-(cyclobutylmethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1604) (3S,9S,18S,21S,25R,28S,34S)-9-benzyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1605) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-9-[(4-methoxyphenyl)methyl]-7,10,13,16,22,25,29-heptamethyl-8-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1606) (3S,9S,18S,21S,25R,28S,34S)-9-benzyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1607) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-ethyl-18-isopropyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1608) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(2-phenylethyl)-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1609) (3S,9S,18S,21S,25S,28S,34S)-9-[(2-chlorophenoxy)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1610) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(3-fluorophenyl)methyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1611) (3S,9S,18S,21S,25S,28S,34S)-9-[(3-chlorophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1612) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-(cyclopropylmethyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1613) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-[[2-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1614) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(o-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1615) (3S,9S,18S,21S,25R,28S,34S)-9-[(2-chlorophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1616) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-11-butyl-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1617) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1618) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-(cyclopentylmethyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1619) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5,11-diisobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1620) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1621) (3S,9S,18S,21S,25R,28S,34S)-9-[(3-chlorophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1622) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-5-cyclohexyl-35-(cyclohexylmethyl)-18-isopropyl-6,11,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1623) (3S,9S,18S,21S,25R,28S,34S)-9-[(3-chlorophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1624) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-5-phenethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1625) (3S,9S,18S,21S,25R,28S,34S)-9-[(4-bromophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1626) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(m-tolylmethyl)-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1627) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(2-phenylethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1628) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-5-benzyl-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,15,19,33,36-hexamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1629) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1630) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-[[4-(trifluoromethoxy)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1631) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(4-fluorophenyl)methyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1632) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1633) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[2-(trifluoromethoxy)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1634) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-(2-phenylethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1635) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-[[2-(trifluoromethoxy)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1636) (3S,9S,18S,21S,25S,28S,34S)-9-[(2-chlorophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1637) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-[[3-(trifluoromethoxy)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1638) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-ethyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1639) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-11-propyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1640) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-[[3-(trifluoromethoxy)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1641) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-[[2-(trifluoromethoxy)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1642) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-(cyclopropylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1643) (3S,9S,18S,21S,25S,28S,34S)-9-[(3-bromophenyl)methyl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1644) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclohexane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1645) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1646) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1647) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(3,3-difluoropropyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1648) (8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,15,16,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1649) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18,28-bis[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1650) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-18,21-diisobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1651) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-18-isopentyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1652) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9,21-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1653) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1654) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1655) (3S,6R,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(4-fluorophenyl)methyl]-28-isopropyl-6,7,10,13,16,21,22,25,29-nonamethyl-8-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1656) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1657) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11,18-diisobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1658) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1659) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-21-isobutyl-N,N,7,10,13,16,22,26,29-nonamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-25-carboxamide,   (1660) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-(3,3-difluoropropyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1661) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,19,33,36-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1662) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18,28-bis[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1663) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-(cyclopentylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1664) (5S,8S,11S,15S,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,16,19,32,33,36-nonamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1665) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-35-(2,2,2-trifluoroethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1666) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-cyclopropyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1667) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,32a′R,38&#39;S,40a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-38′-(4-fluorobenzyl)-19′-isopropyl-7′,12′,13′,16′,20′,39′-hexamethylhexacosahydro-5′H-spiro[cyclopentane-1,22′-tripyrrolo[2,1-i:2′,1′-o:2″,1″-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,37′,40′(15′H,23′H)-undecaone,   (1668) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-21-(propoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1669) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-cyclopentyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1670) (8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1671) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18,21-bis[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1672) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclobutan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1673) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1674) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,35,36-octamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1675) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(cyclohexylmethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1676) (11S,17S,26S,29S,33S,36S)-9-benzyl-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-isopropyl-15,18,21,24,29,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1677) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-cyclopropyl-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1678) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-ethyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1679) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1680) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29,31,31-nonamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1681) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,9,10,13,16,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1682) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1683) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-35-benzyl-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-isopropyl-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1684) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,35-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1685) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1686) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-9,18-bis[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1687) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(hydroxymethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1688) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,25,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1689) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopentylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1690) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-(cyclopropoxymethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1691) (3S,6R,9S,18S,21S,25R,28S,34S)-9-benzyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-isopropyl-6,7,10,13,16,21,22,25,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1692) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-pentyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1693) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-8-(3-pyridylmethyl)-33-(pyrrolidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1694) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1695) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopropan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1696) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1697) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-8-isopentyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1698) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(4-fluorobenzyl)-19′-isopropyl-7′,12′,13′,17′,20′,34′,37′-heptamethyl-16′-(piperidine-1-carbonyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1699) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1700) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-(3,3-difluoropropyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1701) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-21-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1702) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(4-fluorobenzyl)-18-isopropyl-5,6,11,12,15,19,32,33,36-nonamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1703) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-4,9,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(morpholine-4-carbonyl)-22-(3-pyridylmethyl)spiro[f1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1704) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-11-(2,2,2-trifluoroethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1705) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-11-pentyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1706) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,15,19,33,36-heptamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1707) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-18-pentyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1708) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclohexan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1709) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-35-isopentyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1710) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1711) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1712) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-butyl-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1713) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-(hydroxymethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1714) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-36-ethyl-11-isobutyl-5,6,12,15,19,33-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1715) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,30&#39;S,33′R,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(cyclohexylmethyl)-19′-isopropyl-7′,12′,13′,17′,20′,33′,34′,37′-octamethyl-16′-(pyrrolidine-1-carbonyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1716) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclobutylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1717) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,16,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1718) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(morpholine-4-carbonyl)-8-(3-pyridylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1719) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-28-pentyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1720) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1721) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(hydroxymethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1722) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1723) (3S,9S,18S,21S,25S,28S,34S)-18-butyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1724) (5S,8S,11S,15S,18S,23aS,29S,32R,35S,37aS)-35-benzyl-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-isopropyl-5,6,11,12,16,19,32,33,36-nonamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1725) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,30&#39;S,32a′R,38&#39;S,40a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-38′-(4-fluorobenzyl)-19′-isopropyl-7′,12′,13′,17′,20′,39′-hexamethyl-16′-(piperidine-1-carbonyl)hexacosahydro-5′H-spiro[cyclopentane-1,22′-tripyrrolo[2,1-i:2′,1′-o:2″,1″-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,37′,40′(15′H,23′H)-undecaone,   (1726) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1727) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1728) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1729) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-N,N,7,10,13,16,22,26,29-nonamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-25-carboxamide,   (1730) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,32a′R,38&#39;S,40a&#39;S)-38′-benzyl-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-isopropyl-7′,12′,13′,16′,20′,39′-hexamethylhexacosahydro-5′H-spiro[cyclopentane-1,22′-tripyrrolo[2,1-i:2′,1′-o:2″,1″-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,37′,40′(15′H,23′H)-undecaone,   (1731) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopropoxymethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1732) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(4-fluorobenzyl)-19′-isopropyl-7′,12′,13′,16′,20′,34′,37′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1733) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1734) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1735) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-pentyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1736) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)-18-(propoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1737) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18,35-diisopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1738) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclopropoxymethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1739) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclopentylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1740) (3S,9S,18S,21S,25S,28S,34S)-21-butyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1741) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-ethyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1742) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,33′R,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(4-fluorobenzyl)-19′-isopropyl-7′,12′,13′,16′,20′,33′,34′,37′-octamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1743) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-ethyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1744) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)-18-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1745) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(morpholine-4-carbonyl)-8-(3-pyridylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1746) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-(cyclobutylmethyl)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1747) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-11-isobutyl-5,6,12,15,19,33,36-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1748) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-36-ethoxy-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1749) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1750) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1751) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,21,21,33,36-nonamethyl-15-(piperidine-1-carbonyl)tetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (1752) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-ethyl-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1753) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-36′-benzyl-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-isopropyl-7′,12′,13′,17′,20′,34′,37′-heptamethyl-16′-(piperidine-1-carbonyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1754) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-8,11-diisobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1755) (3S,6R,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-[(4-fluorophenyl)methyl]-28-isopropyl-6,7,10,13,16,21,22,26,29-nonamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1756) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1757) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1758) (8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-6,12,16,19,33,36-hexamethyl-15-(morpholine-4-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1759) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-(cyclobutylmethyl)-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1760) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-8-ethyl-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1761) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1762) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-N,N,7,10,13,16,22,26,29-nonamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-25-carboxamide,   (1763) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-11-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1764) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-(cyclopropoxymethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1765) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1766) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-18-(cyclopropoxymethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[11,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1767) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11,18-diisopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1768) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-8-(hydroxymethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1769) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(3,3-difluoropropyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1770) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1771) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-28-(propoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1772) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1773) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,15,16,19,32,33,36-decamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1774) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18,28-bis[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1775) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-18-ethyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1776) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopentyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1777) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1778) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,36&#39;S,38a&#39;S)-36′-benzyl-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-isopropyl-7′,12′,13′,16′,20′,34′,37′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1779) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-21-isobutyl-N,N,7,10,13,16,22,26,29-nonamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-25-carboxamide,   (1780) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,8,12,16,19,33,36-octamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1781) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1782) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-(3,3-difluoropropyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1783) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,33′R,36&#39;S,38a&#39;S)-36′-benzyl-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-isopropyl-7′,12′,13′,16′,20′,33′,34′,37′-octamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1784) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,33′R,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(cyclohexylmethyl)-19′-isopropyl-7′,12′,13′,16′,17′,20′,33′,34′,37′-nonamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1785) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-36-ethoxy-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1786) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-(cyclopropoxymethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1787) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1788) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,30&#39;S,33′R,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(cyclohexylmethyl)-19′-isopropyl-7′,12′,13′,17′,20′,33′,34′,37′-octamethyl-16′-(morpholine-4-carbonyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1789) (3S,9S,18S,21S,25R,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-36-ethoxy-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1790) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18,28-bis[(1S)-1-methylpropyl]-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1791) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-8,18-diisopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1792) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-7,10,13,16,22,25,26,29-octamethyl-18,28-bis[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1793) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1794) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1795) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1796) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-cyclopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1797) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-(3,3-difluoropropyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1798) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-18-isopropyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1799) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-18-(hydroxymethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1800) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,15,16,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1801) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,15,19,33,36-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1802) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,18,22,26,29-octamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1803) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11,35-diisobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1804) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1805) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-(propoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1806) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,30&#39;S,33′R,36&#39;S,38a&#39;S)-36′-benzyl-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-isopropyl-7′,12′,13′,17′,20′,33′,34′,37′-octamethyl-16′-(piperidine-1-carbonyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1807) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1808) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,25,26,29-nonamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1809) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,15,16,19,33,36-octamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1810) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16-cyclohexyl-31-(cyclohexylmethyl)-4,9,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-22-(3-pyridylmethyl)-13-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1811) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-8-(cyclopropoxymethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1812) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-N,N,7,10,13,16,22,26,29-nonamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-25-carboxamide,   (1813) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,15,16,19,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1814) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18,28-bis[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1815) (3S,9S,18S,21S,25S,28S,34S)-28-butyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1816) (5S,8S,11S,15S,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(4-fluorobenzyl)-18-isopropyl-5,6,11,12,16,19,32,33,36-nonamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1817) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclobutylmethyl)-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1818) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-cyclopentyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1819) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)icosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-4,7,10,13,17,20,23,25,28,31,34,37(14H,22H,26H)-dodecaone,   (1820) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-(cyclopentylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1821) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1822) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopropyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1823) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-butyl-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1824) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-18-cyclopentyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1825) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-cyclopentyl-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1826) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-8-pentyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1827) (5S,8S,11S,15S,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,11,12,16,19,32,33,36-nonamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1828) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1829) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-9-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1830) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-9-isopentyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1831) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-8-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1832) (3S,9S,18S,21S,25S,28S,34S)-9-butyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1833) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isopentyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1834) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-8-(3-pyridylmethyl)-33-(pyrrolidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1835) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-cyclopentyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1836) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-N,N,7,10,13,16,22,26,29-nonamethyl-18,28-bis[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-25-carboxamide,   (1837) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-(hydroxymethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1838) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-18-(cyclopentylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1839) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,30&#39;S,32a′R,38&#39;S,40a&#39;S)-38′-benzyl-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-19′-isopropyl-7′,12′,13′,17′,20′,39′-hexamethyl-16′-(piperidine-1-carbonyl)hexacosahydro-5′H-spiro[cyclopentane-1,22′-tripyrrolo[2,1-i:2′,1′-o:2″,1″-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,37′,40′(15′H,23′H)-undecaone,   (1840) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1841) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-(2,2,2-trifluoroethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1842) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1843) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1844) (3S,6R,9S,18S,21S,25S,28S,34S)-9-benzyl-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-isopropyl-6,7,10,13,16,21,22,26,29-nonamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1845) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopropane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1846) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-pentyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1847) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-8-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1848) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1849) (8S,11S,17S,26S,29S,33R,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,33,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-8-(3-pyridylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1850) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1851) (3S,9S,18S,21S,25R,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-36-ethoxy-21,28-diisobutyl-7,10,13,16,22,25,26,29-octamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1852) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1853) (9&#39;S,12&#39;S,16&#39;S,19&#39;S,24a&#39;S,30&#39;S,33′R,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(4-fluorobenzyl)-19′-isopropyl-7′,12′,13′,17′,20′,33′,34′,37′-octamethyl-16′-(piperidine-1-carbonyl)tetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (1854) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-35-pentyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1855) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-18-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1856) (3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1857) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-28-(cyclopropoxymethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1858) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1859) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-18-butyl-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1860) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-(cyclobutylmethyl)-35-(cyclohexylmethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1861) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isopentyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1862) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-18-cyclopropyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1863) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,11-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1864) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-8-(2,2,2-trifluoroethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1865) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-N,N,7,10,13,16,22,26,29-nonamethyl-18,28-bis[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-25-carboxamide,   (1866) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-18-isopropyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1867) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-28-isopropyl-N,N,7,10,13,16,22,26,29-nonamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-25-carboxamide,   (1868) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(pyrrolidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1869) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1870) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1871) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-21-propyl-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1872) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1873) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[(3-bromophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1874) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,19,33,36-hexamethyl-35-(4-methylbenzyl)-15-phenethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1875) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1876) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-fluorophenyl)methyl]-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6,16-bis[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1877) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopentylmethyl)-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1878) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(3,4-difluorophenyl)methyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1879) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-cyclobutyl-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1880) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-22-(o-tolylmethyl)-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1881) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-22-[2-(4-pyridyl)ethyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1882) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-fluorophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1883) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-15-allyl-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,19,33,36-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1884) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1885) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-fluorophenyl)methyl]-3,4,9,10,14,17,23,29,32-nonamethyl-6,16-bis[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1886) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-[2-(3-pyridyl)ethyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1887) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-22-benzyl-25-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-3,4,9,10,14,17,23,29,32-nonamethyl-6,16-bis[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1888) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-iodophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1889) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-22-benzyl-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1890) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1891) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11,15-diisobutyl-5,6,12,19,33,36-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1892) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-22-[2-(3-pyridyl)ethyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1893) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[(4-bromophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1894) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1895) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-22-benzyl-25-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6,16-bis[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1896) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-9-(propoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1897) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-19-isopropyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-(4-pyridylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (1898) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-(3,3-difluoropropyl)-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1899) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11,15-diisobutyl-5,6,12,19,33,36-hexamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1900) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-9-(propoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1901) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-ethyl-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1902) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-[[4-(trifluoromethoxy)phenyl]methyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1903) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-methoxyphenyl)methyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1904) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1905) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1906) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-cyclobutyl-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1907) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-(3,3-difluoropropyl)-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1908) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-18-isopropyl-7,10,13,16,22,26,29-heptamethyl-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1909) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-22-benzyl-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1910) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(3-iodophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1911) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-22-[3-(methylamino)-3-oxo-propyl]-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1912) (5S,8S,11S,14aR,21S,26aS,32S,38S,40aS)-8,21-di((S)-sec-butyl)-32-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,22,36,39-hexamethyl-38-(4-methylbenzyl)hexacosahydro-2H-spiro[azeto[1,2-j]pyrido[1,2-e1]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-24,1′-cyclopentan]-4,7,10,13,20,23,26,31,34,37,40(25H)-undecaone,   (1913) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-22-(4-pyridylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1914) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-fluorophenyl)methyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1915) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1916) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopentylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-21-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1917) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,19,23,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-22-(4-pyridylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (1918) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11,15-diisobutyl-5,6,12,19,33,36-hexamethyl-35-(4-(trifluoromethyl)benzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1919) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,19,33,36-hexamethyl-35-(4-methylbenzyl)-15-(trifluoromethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1920) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-[[4-(trifluoromethoxy)phenyl]methyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1921) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-22-[3-(methylamino)-3-oxo-propyl]-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1922) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(3-methoxyphenyl)methyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1923) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopentylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1924) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-22-(o-tolylmethyl)-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1925) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-18-isopropyl-7,10,13,16,22,26,29-heptamethyl-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1926) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[[4-(difluoromethyl)phenyl]methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1927) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-cyanophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1928) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-18-isopropyl-7,10,13,16,22,26,29-heptamethyl-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1929) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(propoxymethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1930) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[[4-(difluoromethyl)phenyl]methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1931) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopentylmethyl)-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1932) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1933) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-21-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1934) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1935) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-22-[(4-methoxyphenyl)methyl]-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1936) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclobutane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1937) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclopentylmethyl)-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(morpholine-4-carbonyl)-29-propyl-8-(3-pyridylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1938) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18,28-bis[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1939) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-3-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1940) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-3-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1941) (3S,9S,18S,21S,25S,28S,34S)-3-[2-(4-chlorophenyl)ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1942) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-22-benzyl-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,4,9,10,14,17,23,29,32-nonamethyl-6,16-bis[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1943) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(3,4-difluorophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1944) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(3-iodophenyl)methyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1945) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-[[3-(trifluoromethoxy)phenyl]methyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1946) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclopentylmethyl)-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-29-propyl-8-(3-pyridylmethyl)-33-(pyrrolidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (1947) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-3-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1948) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1949) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-9-(propoxymethyl)-21-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1950) (3S,9S,18S,21S,25S,28S,34S)-3-[2-(4-chlorophenyl)ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1951) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-fluorophenyl)methyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1952) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-fluorophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1953) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-iodophenyl)methyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1954) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1955) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1956) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-9-(propoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1957) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1958) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-ethyl-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1959) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-cyanophenyl)methyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1960)N-(tert-butyl)-2-(((5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,19,33,36-hexamethyl-35-(4-methylbenzyl)-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-15-yl)methoxy)acetamide,   (1961) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-cyclobutyl-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,3437-undecaoxotetratriacontahydro-2H4H-spiro[azeto[22,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentane]-15-carboxamide,   (1962) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-(4-pyridylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1963) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1964) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[(4-bromophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1965) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1966) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-9-(propoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1967) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,19,33,36-hexamethyl-35-(4-methylbenzyl)-15-(prop-2-yn-1-yl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1968) (3S,9S,18S,21S,25S,28S,34S)-3-[2-(4-chlorophenyl)ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1969) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopentylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1970) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-[[3-(trifluoromethoxy)phenyl]methyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1971) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-9-(propoxymethyl)-21-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1972) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-21-propyl-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1973) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,19,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-(4-pyridylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (1974) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11,15-diisobutyl-5,6,12,16,19,33,36-heptamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1975) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopentylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1976) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopentylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1977) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-ethoxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1978) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1979) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18,28-bis[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1980) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[2-(4,4-difluoro-1-piperidyl)-2-oxo-ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1981) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(3-cyanophenyl)methyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1982) (3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-19-isopropyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-22-(4-pyridylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-13-carboxamide,   (1983) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-21-propyl-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1984) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-25-(pyrrolidine-1-carbonyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1985) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)-22-[2-(4-pyridyl)ethyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1986) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-fluorophenyl)methyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1987) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(4-fluorophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1988) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-18-cyclobutyl-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1989) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-22-benzyl-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6,16-bis[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1990) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-ethoxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1991) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-22-[(3-methoxyphenyl)methyl]-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (1992) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-22-benzyl-25-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-3,4,9,10,14,17,23,29,32-nonamethyl-6,16-bis[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1993) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-9-[[4-(trifluoromethyl)phenyl]methyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1994) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-21-propyl-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1995) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-11,15-diisobutyl-5,6,12,19,33,36-hexamethyl-35-(4-methylbenzyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (1996) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-21-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1997) (3S,6S,9S,13S,16S,22R,25S,31S,34S)-22-benzyl-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,4,9,10,14,17,23,29,32-nonamethyl-6,16-bis[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (1998) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopentylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)-21-propyl-spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (1999) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclopentylmethyl)-21-ethyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(morpholine-4-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2000) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[(3-bromophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2001) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-25-(pyrrolidine-1-carbonyl)spiro[11,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2002) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-22-[(3-cyanophenyl)methyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2003) (5S,8S,11S,14aR,20S,25aS,31S,37S,39aS)-8,20-di((S)-sec-butyl)-31-(3-chloro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,21,35,38-hexamethyl-37-(4-methylbenzyl)tetracosahydro-2H,4H-spiro[azeto[1,2-j]dipyrrolo[1,2-e1:1′,2′-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-23,1′-cyclopentan]-4,7,10,13,19,22,25,30,33,36,39(14H,24H)-undecaone,   (2004) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-21-propyl-9-(p-tolylmethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2005) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(propoxymethyl)-21-propyl-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2006) (3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(propoxymethyl)-25-(pyrrolidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2007) (8S,11S,17S,26S,29S,33S,36S)-8-[(2-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-17-(p-tolylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2008) (8S,11S,17S,26S,29S,33S,36S)-8-[(2-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(pyrrolidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2009) (5S,8S,12R,15S,20aS,26S,29R,32S,34aS,39aS)-5-((S)-sec-butyl)-26-(3-chloro-4-(trifluoromethyl)phenethyl)-32-(cyclohexylmethyl)-15-isopropyl-8,9,12,16,29,30,33-heptamethyltetracosahydrospiro[azeto[1,2-g]dipyrrolo[1,2-j:1′,2′-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-18,1′-cyclopentan]-4,7,10,14,17,20,25,28,31,34,39(2H,11H,19H)-undecaone,   (2010) (5S,8S,12R,15S,20aS,26S,29R,32S,37aS)-5-((S)-sec-butyl)-26-(3-chloro-4-(trifluoromethyl)phenethyl)-32-(cyclohexylmethyl)-15-isopropyl-8,9,12,16,29,30,33,36-octamethyldocosahydrospiro[azeto[1,2-g]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-18,1′-cyclopentan]-4,7,10,14,17,20,25,28,31,34,37(2H,11H,19H)-undecaone,   (2011) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[(2-chlorophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-N,N,3,4,9,10,14,17,23,29,32-undecamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2012) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-ethyl-18-isopropyl-6,11,12,15,19,32,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2013) (5S,8S,12R,15S,20aS,26S,29R,32S,34aS,38aS)-5-((S)-sec-butyl)-26-(3-chloro-4-(trifluoromethyl)phenethyl)-32-(cyclohexylmethyl)-15-isopropyl-8,9,12,16,29,30,33-heptamethyldocosahydro-25H-spiro[bis(azeto)[1,2-g:1′,2′-j]pyrrolo[1,2-v][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-18,1′-cyclopentan]-4,7,10,14,17,20,25,28,31,34,38(2H,11H,19H,34aH)-undecaone,   (2014) (9&#39;S,12&#39;S,16′R,19&#39;S,24a&#39;S,30&#39;S,33′R,36&#39;S,38a&#39;S)-9′-((S)-sec-butyl)-30′-(3-chloro-4-(trifluoromethyl)phenethyl)-36′-(cyclohexylmethyl)-7′-ethyl-19′-isopropyl-12′,13′,16′,20′,33′,34′,37′-heptamethyltetracosahydro-5′H-spiro[cyclopentane-1,22′-dipyrrolo[2,1-i:2′,1′-u][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin]-5′,8′,11′,14′,18′,21′,24′,29′,32′,35′,38′(15′H,23′H)-undecaone,   (2015) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-5,35-bis(cyclohexylmethyl)-18-isopropyl-6,11,12,15,19,32,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2016) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-6,11,12,15,19,32,33,36-octamethyl-5-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2017) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-5-butyl-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-6,11,12,15,19,32,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2018) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5-isobutyl-18-isopropyl-6,11,12,15,19,32,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2019) (5S,8S,11S,15R,18S,23aS,29S,32R,35S,37aS)-5-benzyl-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-6,11,12,15,19,32,33,36-octamethyldocosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2020) (8S,11S,17S,26S,29S,33S,36S)-8-[(2-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-36-isopropyl-9,15,18,21,24,29,30,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-33-(morpholine-4-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2021) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-[3-(4,4-difluoro-1-piperidyl)propyl]-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2022) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-[2-(4,4-difluoro-1-piperidyl)ethyl]-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2023) (3S,6S,9S,13S,16S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-23-[2-(2-hydroxy-2-methyl-propoxy)ethyl]-9-isobutyl-N,N,3,4,10,14,17,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2024) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-9-[2-(2,2,2-trifluoroethoxy)ethyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2025) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9-[2-(2-methoxyethoxy)ethyl]-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2026) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-9-(3-pyridylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2027) (3S,6S,9S,13R,16S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-23-[2-(2-hydroxy-2-methyl-propoxy)ethyl]-9-isobutyl-3,4,10,13,14,17,29,32-octamethyl-6,16-bis[(1S)-1-methylpropyl]-31-(propoxymethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (2028) (3S,6S,9S,13S,16S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-23-[2-(2-hydroxy-2-methyl-propoxy)ethyl]-9-isobutyl-N,N,3,4,10,14,17,29,32-nonamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2029) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-9-[2-(4-pyridyl)ethyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2030) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-9-(2-oxaspiro[3.3]heptan-6-yl)-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2031) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-9-(oxetan-3-ylmethyl)-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2032) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-9-[2-(3-pyridyl)ethyl]-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2033) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-9-(4-pyridylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2034) (3S,6S,9S,13S,16S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-23-[2-(2-hydroxy-2-methyl-propoxy)ethyl]-9-isobutyl-N,N,3,4,10,14,17,29,32-nonamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2035) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(2,2-difluorospiro[3.3]heptan-6-yl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2036) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-[2-(2,2-difluoroethoxy)ethyl]-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2037) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(2-hydroxyethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2038) 2-[2-[(11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-9-yl]ethoxy]-N,N-dimethyl-acetamide,   (2039) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-(3,4-dichlorophenoxy)ethyl]-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2040) (3S,9S,18S,21S,25S,28S,34S)-3-[2-(4-chlorophenoxy)ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2041) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[2-[4-(trifluoromethyl)phenoxy]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2042) (3S,9S,18S,21S,25S,28S,34S)-3-[(4-chlorophenoxy)methyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2043) (3S,9S,18S,21S,25S,28S,34S)-3-[(2-chlorophenyl)methoxymethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2044) (3S,9S,18S,21S,25S,28S,34S)-3-[(4-chlorophenyl)methoxymethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2045) (3S,9S,18S,21S,25S,28S,34S)-3-[(3-chlorophenyl)methoxymethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2046) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(5-hydroxypent-2-enyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1 S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2047) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(4-hydroxy-4-methyl-pent-2-enyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2048) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-(2-tetrahydropyran-4-ylethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2049) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(5-hydroxypentyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2050) tert-butyl 3-[2-[(8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-8-yl]ethylidene]azetidine-1-carboxylate,   (2051) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9-[(E)-4-methoxybut-2-enyl]-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2052) 4-[(11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-9-yl]-N,N-dimethyl-butanamide,   (2053) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-(2-tetrahydropyran-4-ylideneethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2054) 4-[(11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-9-yl]-N,N-dimethyl-but-2-enamide,   (2055) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[3-[4-(trifluoromethyl)phenyl]propyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2056) tert-butyl 3-[2-[(8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-8-yl]ethyl]azetidine-1-carboxylate,   (2057) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethoxy)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2058) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-3-[2-(4-methylsulfonylphenyl)ethyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2059) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[2-(3,4,5-trichlorophenyl)ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2060) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(2-(6-(difluoromethyl)pyridin-3-yl)ethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2061) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-3-[2-(3,4-dichloro-5-methoxy-phenyl)ethyl]-28-isopropyl-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2062) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-(3,4-dichloro-5-isopropoxy-phenyl)ethyl]-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2063) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-29-(2-(benzofuran-5-yl)ethyl)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2064) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-29-(2-(1-methyl-1H-indol-5-yl)ethyl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2065) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-29-(2-(1-methyl-1H-indol-6-yl)ethyl)-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2066) (3S,9S,18S,21S,25S,28S,34S)-3-[2-(3-butoxy-4,5-dichloro-phenyl)ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2067) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(3-fluoro-4-(trifluoromethoxy)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2068) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[2-(3,4,5-trichlorophenyl)ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2069) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-29-(2-(5-(trifluoromethyl)pyridin-2-yl)ethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2070) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-29-(2-(quinolin-6-yl)ethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2071) 2,3-dichloro-5-[2-[(3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-3-yl]ethyl]benzonitrile,   (2072) 5-(2-((5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxo-15-(piperidine-1-carbonyl)tetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-29-yl)ethyl)-2-(trifluoromethyl)benzonitrile,   (2073) (3S,9S,18S,21S,25S,28S,34S)-3-[2-(3-tert-butoxy-4,5-dichloro-phenyl)ethyl]-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2074) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)ethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2075) 2,3-dichloro-5-[2-[(3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,27,30,33-undecaoxo-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-3-yl]ethyl]benzonitrile,   (2076) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(4-(difluoromethoxy)-3-fluorophenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2077) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-29-(2-(quinolin-7-yl)ethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2078) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)-29-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2079) (3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-3-[2-(3,4-dichloro-5-isopropoxy-phenyl)ethyl]-28-isopropyl-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2080) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-29-(3-methoxy-4-(trifluoromethyl)phenethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2081) (3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-(3,4-dichloro-5-methoxy-phenyl)ethyl]-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2082) (3S,9S,18S,21S,25S,28S,34S)-3-[2-(3-tert-butoxy-4,5-dichloro-phenyl)ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1 S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2083) (3S,9S,18S,21S,25S,28S,34S)-3-[2-(3-butoxy-4,5-dichloro-phenyl)ethyl]-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,22,26,29-octamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2084) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-29-(2-(6-methoxypyridin-3-yl)ethyl)-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2085) (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(4-(difluoromethyl)-3-fluorophenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidine-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone,   (2086) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-12-[2-(4-chloro-2-fluoro-phenyl)ethyl]-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2087) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-12-[2-(2,4,5-trifluorophenyl)ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2088) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2089) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-12-[2-(2,4-difluorophenyl)ethyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2090) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-12-[2-(2,4,6-trifluorophenyl)ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2091) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-12-[2-(2,3,4,5,6-pentafluorophenyl)ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2092) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-12-[2-(2-chloro-6-fluoro-phenyl)ethyl]-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2093) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-12-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2094) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-12-[2-(5-chloro-2-fluoro-phenyl)ethyl]-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2095) (3S,6S,9S,12S,18S,27S,30S,34R)-6-benzyl-18-[(4-chlorophenyl)methyl]-3,9-diisobutyl-4,7,16,19,22,25,30,31,34-nonamethyl-27-[(1S)-1-methylpropyl]-12-[2-[3-(trifluoromethyl)phenyl]ethyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2096) (3S,9S,18S,21S,25S,28S,31S,34S)-31-benzyl-9-[(4-chlorophenyl)methyl]-3-[2-[2-fluoro-4-(trifluoromethyl)phenyl]ethyl]-28-isobutyl-7,10,13,16,21,22,29,32-octamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2097) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-22-(2-oxo-2-pyrrolidin-1-yl-ethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2098) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[3-(3,3-difluoroazetidin-1-yl)-3-oxo-propyl]-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-1[(1S)-1-methylpropyl]-13-(morpholine-4-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (2099) (3S,9S,12S,18S,27S,30S,34S)-34-(3,3-difluoropiperidine-1-carbonyl)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-9-[(4-methoxyphenyl)methyl]-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2100) 3-[(3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-34-(piperidine-1-carbonyl)-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-6-yl]-N,N-dimethyl-propanamide,   (2101) (3S,9S,12S,18S,27S,30S,34S)-34-(4,4-difluoropiperidine-1-carbonyl)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-9-[(4-methoxyphenyl)methyl]-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2102) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[2-(azetidin-1-yl)-2-oxo-ethyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2103) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[3-(azetidin-1-yl)-3-oxo-propyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(morpholine-4-carbonyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (2104) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(morpholine-4-carbonyl)-22-(3-oxo-3-pyrrolidin-1-yl-propyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (2105) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-22-[2-oxo-2-(1-piperidyl)ethyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2106) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(dimethylamino)-2-oxo-ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2107) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(morpholine-4-carbonyl)-22-(3-morpholino-3-oxo-propyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (2108) 3-[(3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(morpholine-4-carbonyl)-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-22-yl]-N,N-dimethyl-propanamide,   (2109) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-22-(2-morpholino-2-oxo-ethyl)-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2110) 3-[(3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-22-butyl-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,20,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontan-19-yl]-N,N-dimethyl-propanamide,   (2111) 3-[(3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(morpholine-4-carbonyl)-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-22-yl]-N-methyl-propanamide,   (2112) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(morpholine-4-carbonyl)-22-[3-oxo-3-(1-piperidyl)propyl]spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-2,5,8,11,15,18,21,24,27,30,33-undecone,   (2113) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-36-(triazol-1-yl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2114) (6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-22-(phenoxymethyl)-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (2115) (3S,9S,18S,21S,25S,28S,34S,36S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-36-(triazol-1-yl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2116) (3S,9S,18S,21S,25R,28S,34S,36R)-36-benzyloxy-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-8-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2117) (3S,9S,18S,21S,25S,28S,34S,36S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-(2-hydroxyethoxy)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2118) (3S,9S,18S,21S,25S,28S,34S,36R)-9-(cyclohexylmethyl)-36-ethoxy-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2119) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-(2,2-difluoroethoxy)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2120) (3S,9S,18S,21S,25S,28S,34S,36S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-36-(3-pyridylmethoxy)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2121) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-36-(3-pyridylmethoxy)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2122) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-(2-hydroxyethoxy)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2123) (3S,9S,18S,21S,25S,28S,34S,36S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-(2,2-difluoroethoxy)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2124) (3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-36-(3-thienylmethoxy)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2125) (3S,9S,18S,21S,25S,28S,34S,36R)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-36-(m-tolylmethoxy)-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2126) (3S,9S,18S,21S,25S,28S,34S,36S)-36-[(3-chlorophenyl)methoxy]-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2127) (3S,9S,18S,21S,25S,28S,34S,36S)-9-(cyclohexylmethyl)-36-ethoxy-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone, -(2128) (3S,9S,18S,21S,25S,28S,34S,36R)-9-(cyclohexylmethyl)-36-[[4-(difluoromethoxy)phenyl]methoxy]-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2129) (3S,9S,18S,21S,25S,28S,34S,36S)-36-[(4-chlorophenyl)methoxy]-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2130) (3S,9S,18S,21S,25S,28S,34S,36R)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-36-(p-tolylmethoxy)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2131) (3S,9S,18S,21S,25S,28S,34S,36R)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-36-[(3-methoxyphenyl)methoxy]-7,10,13,16,22,26,29-heptamethyl-18-1[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2132) (3S,9S,18S,21S,25S,28S,34S,36S)-36-[(2-chlorophenyl)methoxy]-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2133) (3S,9S,18S,21S,25S,28S,34S,36R)-36-[(4-chlorophenyl)methoxy]-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2134) (3S,9S,18S,21S,25S,28S,34S,36R)-36-[(3-chlorophenyl)methoxy]-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2135) (3S,9S,18S,21S,25S,28S,34S,36S)-9-(cyclohexylmethyl)-36-[[4-(difluoromethoxy)phenyl]methoxy]-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2136) (3S,9S,18S,21S,25S,28S,34S,36S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-36-[(3-methoxyphenyl)methoxy]-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2137) (3S,9S,18S,21S,25S,28S,34S,36S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-36-(o-tolylmethoxy)-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2138) (3S,9S,18S,21S,25S,28S,34S,36R)-36-[(2-chlorophenyl)methoxy]-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2139) (3S,9S,18S,21S,25S,28S,34S,36R)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-36-(o-tolylmethoxy)-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2140) (3S,9S,18S,21S,25S,28S,34S,36S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-36-(p-tolylmethoxy)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2141) (3S,9S,18S,21S,25S,28S,34S,36S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-36-(m-tolylmethoxy)-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone,   (2142) (3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(3-ethynylphenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2143) (11S,17S,26S,29S,33R,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclobutyl-17-(cyclohexylmethyl)-15,18,21,24,29,30,33,34,37-nonamethyl-26-[(1S)-1-methylpropyl]-9-phenyl-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2144) (3S,6S,9S,13S,16S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16,31-di(cyclobutyl)-3,4,9,10,14,17,19,19,20,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-23-phenyl-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (2145) (3S,12S,18S,27S,30S,34R)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3-cyclobutyl-18-(cyclohexylmethyl)-1,4,6,6,7,16,19,22,25,30,31,34-dodecamethyl-27-[(1S)-1-methylpropyl]-10-phenyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2146) (3S,6S,9S,13S,16S,25S,31S,34S)-23-(3-chlorophenyl)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16,31-di(cyclobutyl)-3,4,9,10,14,17,19,19,20,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (2147) (3S,6S,9S,13S,16S,25S,31S,34S)-23-(4-chlorophenyl)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16,31-di(cyclobutyl)-3,4,9,10,14,17,19,19,20,29,32-undecamethyl-6-[(1S)-1-methylpropyl]-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (2148) (3S,6S,9S,13R,16S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-16,31-di(cyclobutyl)-3,4,9,10,13,14,17,19,19,20,29,32-dodecamethyl-6-[(1S)-1-methylpropyl]-23-phenyl-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone,   (2149) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclobutyl-17-(cyclohexylmethyl)-15,18,21,24,29,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-9-(3-thienyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2150) (3S,12S,18S,27S,30S,34S)-12-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-3-cyclobutyl-18-(cyclohexylmethyl)-1,4,6,6,7,16,19,22,25,30,31-undecamethyl-27-1-[(1S)-1-methylpropyl]-10-phenyl-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone,   (2151) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclobutyl-17-(cyclohexylmethyl)-15,18,21,24,29,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-9-phenyl-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2152) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-(cyclobutylmethyl)-35-(cyclohexylmethyl)-5,6,11,12,15,16,19,21,21,22,33,36-dodecamethyltetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (2153) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,18-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-5,6,11,12,15,16,19,21,21,22,33,36-dodecamethyltetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (2154) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-ethyl-5,6,11,12,15,16,19,21,21,22,33,36-dodecamethyltetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (2155) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclohexyl-35-(cyclohexylmethyl)-5,6,11,12,15,16,19,21,21,22,33,36-dodecamethyltetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (2156) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-5,6,11,12,15,16,19,21,21,22,33,36-dodecamethyltetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (2157) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-18-cyclobutyl-35-(cyclohexylmethyl)-5,6,11,12,15,16,19,21,21,22,33,36-dodecamethyltetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (2158) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-(cyclopentylmethyl)-5,6,11,12,15,16,19,21,21,22,33,36-dodecamethyltetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (2159) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,11-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,15,16,19,21,21,22,33,36-undecamethyltetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (2160) (5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isobutyl-5,6,11,12,15,16,19,21,21,22,33,36-dodecamethyltetracosahydro-2H-azete[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratoriacontin-4,7,10,13,17,20,23,28,31,34,37(14H)-undecaone,   (2161) (8S,11S,17S,26S,29S,33S,36S)-8-[(2-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-9-ethyl-36-isopropyl-15,18,21,24,29,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2162) (8S,11S,17S,26S,29S,33S,36S)-8-[(2-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-9-ethyl-36-isopropyl-15,18,21,24,29,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(pyrrolidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2163) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[(2-chlorophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-23-ethyl-N,N,3,4,9,10,14,17,29,32-decamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2164) (8S,11S,17S,26S,29S,33S,36S)-8-[(2-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-9-ethyl-36-isopropyl-N,N,15,18,21,24,29,30,34,37-decamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-33-carboxamide,   (2165) (3S,6S,9S,13S,16S,22S,25S,31S,34S)-22-[(2-chlorophenyl)methyl]-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-23-ethyl-9-isobutyl-N,N,3,4,10,14,17,29,32-nonamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2166) (8S,11S,17S,26S,29S,33S,36S)-8-[(2-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-ethyl-36-isopropyl-15,18,21,24,29,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-17-(p-tolylmethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2167) (8S,11S,17S,26S,29S,33S,36S)-8-[(2-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-9-ethyl-36-isopropyl-15,18,21,24,29,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(morpholine-4-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2168) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-8-(2-methoxyethyl)-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2169) 5-[[(8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-8-yl]methyl]pyridine-2-carbonitrile,   (2170) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-8-[(3-fluoro-4-hydroxy-phenyl)methyl]-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2171) (8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-8-[(4-methoxyphenyl)methyl]-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2172) (3S,9S,18S,24R,27S,33S)-18-[(2S)-butan-2-yl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-27-cyclopentyl-N,N,7,10,13,16,25,28-octamethyl-2,5,8,11,14,17,20,26,29,32-decaoxospiro[22-thia-1,4,7,10,13,16,19,25,28,31-decazabicyclo[31.3.0]hexatriacontane-30,1′-cyclopentane]-24-carboxamide,   (2173) (3S,9S,18S,24R,27S,33S)-18,27-bis[(2S)-butan-2-yl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-N,N,7,10,13,16,25,28-octamethyl-9-[(4-methylphenyl)methyl]-2,5,8,11,14,17,20,26,29,32-decaoxospiro[22-thia-1,4,7,10,13,16,19,25,28,31-decazabicyclo[31.3.0]hexatriacontane-30,1′-cyclopentane]-24-carboxamide,   (2174) (3S,9S,12S,17S,20S,23S,29R,32S,38S)-20-[(2S)-butan-2-yl]-32-cyclopentyl-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-N,N,7,10,17,18,24,30,33-nonamethyl-23-(2-methylpropyl)-2,5,8,11,16,19,22,25,31,34,37-undecaoxo-9-(propoxymethyl)spiro[27-thia-1,4,7,10,15,18,21,24,30,33,36-undecazatricyclo[36.3.0.012,15]hentetracontane-35,1′-cyclopentane]-29-carboxamide,   (2175) (3S,9S,18S,21S,27R,30S,36S)-18-[(2S)-butan-2-yl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-30-cyclopentyl-N,N,7,10,13,16,22,28,31-nonamethyl-21-(2-methylpropyl)-2,5,8,11,14,17,20,23,29,32,35-undecaoxospiro[25-thia-1,4,7,10,13,16,19,22,28,31,34-undecazabicyclo[34.3.0]nonatriacontane-33,1′-cyclopentane]-27-carboxamide,   (2176) (3S,9S,12S,17S,20S,23S,29R,32S,38S,40R)-20-[(2S)-butan-2-yl]-9-(cyclohexylmethyl)-32-cyclopentyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-40-ethoxy-N,N,7,10,17,18,24,30,33-nonamethyl-23-(2-methylpropyl)-2,5,8,11,16,19,22,25,31,34,37-undecaoxospiro[27-thia-1,4,7,10,15,18,21,24,30,33,36-undecazatricyclo[36.3.0.012,15]hentetracontane-35,1′-cyclopentane]-29-carboxamide,   (2177) (3S,9S,12S,17S,20S,23S,29R,32S,38S)-20-[(2S)-butan-2-yl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-32-cyclopentyl-N,N,7,10,17,18,24,30,33-nonamethyl-9-[(4-methylphenyl)methyl]-23-(2-methylpropyl)-2,5,8,11,16,19,22,25,31,34,37-undecaoxospiro[27-thia-1,4,7,10,15,18,21,24,30,33,36-undecazatricyclo[36.3.0.012,15]hentetracontane-35,1′-cyclopentane]-29-carboxamide,   (2178) (3S,9S,18S,21S,27R,30S,36S)-18,30-bis[(2S)-butan-2-yl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-N,N,7,10,13,16,22,28,31-nonamethyl-9-[(4-methylphenyl)methyl]-21-(2-methylpropyl)-2,5,8,11,14,17,20,23,29,32,35-undecaoxospiro[25-thia-1,4,7,10,13,16,19,22,28,31,34-undecazabicyclo[34.3.0]nonatriacontane-33,1′-cyclopentane]-27-carboxamide,   (2179) (3S,9S,12S,17S,20S,23S,29R,32S,38S)-20-[(2S)-butan-2-yl]-9,32-dicyclopentyl-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-N,N,7,10,17,18,24,30,33-nonamethyl-23-(2-methylpropyl)-2,5,8,11,16,19,22,25,31,34,37-undecaoxospirof[27-thia-1,4,7,10,15,18,21,24,30,33,36-undecazatricyclo[36.3.0.012,15]hentetracontane-35,1′-cyclopentane]-29-carboxamide,   (2180) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-9-[2-(4-methylpiperazin-1-yl)ethyl]-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2181) (3S,6S,9S,13S,16S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-23-[2-[2-(dimethylamino)ethoxy]ethyl]-9-isobutyl-N,N,3,4,10,14,17,29,32-nonamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2182) (3S,6S,9S,13S,16S,25S,31S,34S)-23-[2-(azetidin-3-yl)ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-25-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2183) (3S,6S,9S,13S,16S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,29,32-nonamethyl-23-[2-[2-(methylamino)ethoxy]ethyl]-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide,   (2184) (11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-9-(2-piperazin-1-ylethyl)-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone,   (2185) (11S,17S,26S,29S,33S,36S)-9-[2-(2-aminoethoxy)ethyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone, and   (2186) (11S,17S,26S,29S,33S,36S)-9-(4-aminobutyl)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone.   

     The present invention also relates to a non-natural amino acid for use in the production of the cyclic peptide compound of the present invention. In an embodiment, the non-natural amino acid of the present invention is an N-protected non-natural amino acid for use in the production of the peptide compound using a solid-phase synthesis method, and in another embodiment, the non-natural amino acid of the present invention is a non-natural amino acid having a free amino group obtained by removing the protecting group from the N-protected non-natural amino acid. Examples of the protecting group of the N-protected non-natural amino acid include an Fmoc group, a Boc group, a Cbz group, an Alloc group, a nosyl group, a dinitronosyl group, a t-Bu group, a trityl group, and a cumyl group. Of these, an Fmoc group, a Boc group, a Cbz group, and an Alloc group are preferable, and an Fmoc group is more preferable. 
     In the present invention, specific examples of the N-protected non-natural amino acid having an Fmoc group as a protecting group include the following amino acids.
     (001_aa053) 3-borono-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid,   (002_aa134) 4-[3,5-difluoro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid,   (003_aa133) 2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[3-fluoro-4-(trifluoromethyl)phenyl]butanoic acid,   (004_aa132) 4-[3-chloro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid,   (005_aa049) 2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]butanoic acid,   (006_aa154) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(3-iodophenyl)propanoic acid,   (007_aa151) 3-(3,4-difluorophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid,   (008_aa128) 3-(5-bromo-2-methyl-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid,   (009_aa127) 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(5-iodo-2-methyl-phenyl)propanoic acid,   (010_aa126) 3-(2-bromo-5-iodo-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid,   (011_aa122) 3-(2-chloro-5-iodo-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid,   (012_aa121) 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-fluoro-5-iodo-phenyl)propanoic acid,   (013_aa120) 3-(3,5-dichlorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid,   (014_aa118) 3-(2,5-difluorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid,   (015_aa116) 3-(2,6-difluorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid,   (016_aa114) 2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]propanoic acid,   (017_aa113) 2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-(p-tolyl)propanoic acid,   (018_aa110) 3-(4-chlorophenyl)-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]propanoic acid,   (019_aa106) 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3-fluoro-5-iodo-phenyl)propanoic acid,   (020_aa105) 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-fluoro-3-iodo-phenyl)propanoic acid,   (021_aa104) 3-(3-chloro-5-iodo-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid,   (022_aa097) 3-(3-bromophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid,   (023_aa096) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(4-iodophenyl)propanoic acid,   (024_aa095) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(2-fluorophenyl)propanoic acid,   (025_aa094) 3-(2-chlorophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid,   (026_aa090) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[4-(trifluoromethyl)phenyl]propanoic acid,   (027_aa087) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[3-(trifluoromethoxy)phenyl]propanoic acid,   (028_aa086) 3-(4-bromophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid,   (029_aa085) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(p-tolyl)propanoic acid,   (030_aa082) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(4-fluorophenyl)propanoic acid,   (031_aa081) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[4-(trifluoromethoxy)phenyl]propanoic acid,   (032_aa080) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(3-fluorophenyl)propanoic acid,   (033_aa077) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(o-tolyl)propanoic acid,   (034_aa074) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[2-(trifluoromethoxy)phenyl]propanoic acid,   (035_aa073) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid,   (036_aa067) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(2-methoxyphenyl)propanoic acid,   (037_aa066) 3-[4-(difluoromethyl)phenyl]-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid,   (038_aa064) 3-(2-cyanophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic   acid,   (039_aa063) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[2-(trifluoromethyl)phenyl]propanoic acid,   (040_aa061) 3-(4-cyanophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid,   (041_aa060) 3-(3-cyanophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid,   (042_aa108) 3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-isopentyloxy-butanoic acid,   (043_aa107) 4-[2-(tert-butylamino)-2-oxo-ethoxy]-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid,   (044_aa119) 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3-iodophenyl)-2-methyl-propanoic acid,   (045_aa098) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-2-methyl-3-phenyl-propanoic acid,   (046_aa088) 1-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]cyclopentanecarboxylic acid,   (047_aa102) 1-(9H-fluoren-9-ylmethoxycarbonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid,   (048_aa101) 1-(9H-fluoren-9-ylmethoxycarbonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid,   (049_aa149) 3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-(1-piperidyl)butanoic acid,   (050_aa052) 3-[9H-fluoren-9-ylmethoxycarbonyl(propyl)amino]-4-oxo-4-(1-piperidyl)butanoic acid,   (051_aa033-b) 4-allyloxy-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-butanoic acid,   (052_aa032) 3-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-4-oxo-4-(1-piperidyl)butanoic acid,   (053_aa031) 3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-yl-butanoic acid,   (054_aa030) 3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxazolidin-3-yl-4-oxo-butanoic acid,   (055_aa029) 3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxazolidin-3-yl-4-oxo-butanoic acid,   (056_aa028) 3-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-4-oxo-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)butanoic acid,   (057_aa027) 3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)butanoic acid,   (058_aa026) 3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3,3,4,4,5,5-hexafluoro-1-piperidyl)-4-oxo-butanoic acid,   (059_aa025) 3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(3,3,4,4,5,5-hexafluoro-1-piperidyl)-4-oxo-butanoic acid,   (060_aa024) 4-(3,3-dimethylpyrrolidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butanoic acid,   (061_aa023) 3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(4-methyl-1-piperidyl)-4-oxo-butanoic acid,   (062_aa022) 3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-morpholino-4-oxo-butanoic acid,   (063_aa021) 4-(1,1-dioxo-1,4-thiazinan-4-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butanoic acid,   (064_aa020) 4-(4-tert-butyl-1-piperidyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butanoic acid,   (065_aa019) 4-(dimethylamino)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butanoic acid,   (066_aa018) 3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-pyrrolidin-1-yl-butanoic acid,   (067_aa017) 3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxo-butanoic acid,   (068_aa016) 3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxo-butanoic acid,   (069_aa015) 4-(1,1-dioxo-1,4-thiazinan-4-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-butanoic acid,   (070_aa014) 3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(4-methyl-1-piperidyl)-4-oxo-butanoic acid,   (071_aa013) 3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-yl-butanoic acid,   (072_aa012) 4-(azetidin-1-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-butanoic acid,   (073_aa011) 4-(dimethylamino)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-butanoic acid,   (074_aa010) 3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxo-butanoic acid,   (075_aa009) 3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxo-butanoic acid,   (076_aa008) 4-(3,3-dimethylpyrrolidin-1-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-butanoic acid,   (077_aa007) 3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-morpholino-4-oxo-butanoic acid,   (078_aa006) 3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-(1-piperidyl)butanoic acid,   (079_aa040) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(4-pyridyl)butanoic acid,   (080_aa039) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(3-pyridyl)butanoic acid,   (081_aa125) 3-(5-bromo-2-thienyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid,   (082_aa124) 3-(5-chloro-2-thienyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid,   (083_aa068) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(3-pyridyl)propanoic acid,   (084_aa065) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(4-pyridyl)propanoic acid,   (085_aa038) 3-(5-bromo-3-pyridyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid,   (086_aa037) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(6-methyl-3-pyridyl)propanoic acid,   (087_aa036) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(6-methoxy-3-pyridyl)propanoic acid,   (088_aa035) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(5-methyl-3-pyridyl)propanoic acid,   (089_aa034) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(5-methoxy-3-pyridyl)propanoic acid,   (090_aa033) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[6-(trifluoromethyl)-3-pyridyl]propanoic acid,   (091_aa153) 4-(3,3-difluoroazetidin-1-yl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-butanoic acid,   (092_aa152) 4-(4,4-difluoro-1-piperidyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-butanoic acid,   (093_aa092) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-methylsulfonyl-butanoic acid,   (094_aa047) 4-(3,3-difluoroazetidin-1-yl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]butanoic acid,   (095_aa093) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-methoxy-butanoic acid,   (096_aa078) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-methoxy-butanoic acid,   (097_aa069) 3-(cyclopropoxy)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid,   (098_aa062) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-methoxy-propanoic acid,   (099_aa055) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-isopentyloxy-propanoic acid,   (100_aa054) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-hydroxy-propanoic acid,   (101_aa045) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(2,2,2-trifluoroethoxy)propanoic acid,   (102_aa044) 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2,2,2-trifluoroethoxy)propanoic acid,   (103_aa043) 3-(cyclobutoxy)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid,   (104_aa042) 3-(cyclobutoxy)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid,   (105_aa041) 3-(cyclopropoxy)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid,   (106_aa150) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-5,5-difluoro-pentanoic acid,   (107_aa091) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4,4,4-trifluoro-butanoic acid,   (108_aa089) 2-cyclopropyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]acetic acid,   (109_aa079) 2-cyclopentyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]acetic acid,   (110_aa075) 2-cyclobutyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]acetic acid,   (111_aa083) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]pent-4-ynoic acid,   (112_aa076) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]hex-5-ynoic acid,   (113_aa048) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]pent-4-enoic acid,   (114_aa141) 3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-methyl-hexanoic acid,   (115_aa131) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-5-methyl-hexanoic acid,   (116_aa130) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]octanoic acid,   (117_aa112) 3-cyclohexyl-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]propanoic acid,   (118_aa111) 2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-4-methyl-pentanoic acid,   (119_aa109) 2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]propanoic acid,   (120_aa084) 2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]heptanoic acid,   (121_aa072) 3-cyclobutyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid,   (122_aa071) 3-cyclopentyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid,   (123_aa070) 3-cyclopropyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid,   (124_aa051) 3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-5-methyl-hexanoic acid,   (125_aa050) 2-[9H-fluoren-9-ylmethoxycarbonyl(propyl)amino]propanoic acid,   (126_aa004) 2-[9H-fluoren-9-ylmethoxycarbonyl(isopropyl)amino]acetic acid,   (127_aa003) 2-[cyclopropyl(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid,   (128_aa002) 2-[2-(4,4-difluoro-1-piperidyl)ethyl-(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid,   (129_aa001) 2-[3-(4,4-difluoro-1-piperidyl)propyl-(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid,   (130_aa155) 2-[3-(dimethylamino)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-oxo-propyl]sulfanylacetic acid,   (131_aa157) 2-[2-(azetidin-3-yl)ethyl-(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid,   (132_aa158) 2-[2-(2-aminoethoxy)ethyl-(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid,   and   (133_aa161) 2-[9H-fluoren-9-ylmethoxycarbonyl-[2-[2-(methylamino)ethoxy]ethyl]amino]acetic acid.   In the present invention, specific examples of the N-protected non-natural amino acid having a Cbz group as a protecting group include the following amino acids.   (z001) 2-(benzyloxycarbonylamino)-3-borono-propanoic acid,   (z002) 2-(benzyloxycarbonylamino)-4-[3,5-difluoro-4-(trifluoromethyl)phenyl]butanoic acid,   (z003) 2-(((benzyloxy)carbonyl)amino)-4-(3-fluoro-4-(trifluoromethyl)phenyl)butanoic acid,   (z004) 2-(((benzyloxy)carbonyl)amino)-4-(3-chloro-4-(trifluoromethyl)phenyl)butanoic acid,   (z005) 2-(benzyloxycarbonylamino)-4-[4-(pentafluoro-_S-sulfanyl)phenyl]butanoic acid,   (z006) 2-[benzyloxycarbonyl(methyl)amino]-3-(3-iodophenyl)propanoic acid,   (z007) 2-[benzyloxycarbonyl(methyl)amino]-3-(3,4-difluorophenyl)propanoic acid,   (z008) 2-(((benzyloxy)carbonyl)amino)-3-(5-bromo-2-methylphenyl)propanoic acid,   (z009) 2-(benzyloxycarbonylamino)-3-(5-iodo-2-methyl-phenyl)propanoic acid,   (z010) 2-(((benzyloxy)carbonyl)amino)-3-(2-bromo-5-iodophenyl)propanoic acid,   (z011) 2-(((benzyloxy)carbonyl)amino)-3-(2-chloro-5-iodophenyl)propanoic acid,   (z012) 2-(((benzyloxy)carbonyl)amino)-3-(2-fluoro-5-iodophenyl)propanoic acid,   (z013) 2-(((benzyloxy)carbonyl)amino)-3-(3,5-dichlorophenyl)propanoic acid,   (z014) 2-(((benzyloxy)carbonyl)amino)-3-(2,5-difluorophenyl)propanoic acid,   (z015) 2-(((benzyloxy)carbonyl)amino)-3-(2,6-difluorophenyl)propanoic acid,   (z016) 2-[benzyloxycarbonyl(ethyl)amino]-3-[4-(trifluoromethyl)phenyl]propanoic acid,   (z017) 2-[benzyloxycarbonyl(ethyl)amino]-3-(p-tolyl)propanoic acid,   (z018) 2-[benzyloxycarbonyl(ethyl)amino]-3-(4-chlorophenyl)propanoic acid,   (z019) 2-(((benzyloxy)carbonyl)amino)-3-(3-fluoro-5-iodophenyl)propanoic acid,   (z020) 2-(benzyloxycarbonylamino)-3-(2-fluoro-3-iodo-phenyl)propanoic acid,   (z021) 2-(benzyloxycarbonylamino)-3-(3-chloro-5-iodo-phenyl)propanoic acid,   (z022) 2-[benzyloxycarbonyl(methyl)amino]-3-(3-bromophenyl)propanoic acid,   (z023) 2-[benzyloxycarbonyl(methyl)amino]-3-(4-iodophenyl)propanoic acid,   (z024) 2-[benzyloxycarbonyl(methyl)amino]-3-(2-fluorophenyl)propanoic acid,   (z025) 2-[benzyloxycarbonyl(methyl)amino]-3-(2-chlorophenyl)propanoic acid,   (z026) 2-[benzyloxycarbonyl(methyl)amino]-3-[4-(trifluoromethyl)phenyl]propanoic acid,   (z027) 2-[benzyloxycarbonyl(methyl)amino]-3-[3-(trifluoromethoxy)phenyl]propanoic acid,   (z028) 2-[benzyloxycarbonyl(methyl)amino]-3-(4-bromophenyl)propanoic acid,   (z029) 2-[benzyloxycarbonyl(methyl)amino]-3-(p-tolyl)propanoic acid,   (z030) 2-[benzyloxycarbonyl(methyl)amino]-3-(4-fluorophenyl)propanoic acid,   (z031) 2-[benzyloxycarbonyl(methyl)amino]-3-[4-(trifluoromethoxy)phenyl]propanoic acid,   (z032) 2-[benzyloxycarbonyl(methyl)amino]-3-(3-fluorophenyl)propanoic acid,   (z033) 2-[benzyloxycarbonyl(methyl)amino]-3-(o-tolyl)propanoic acid,   (z034) 2-[benzyloxycarbonyl(methyl)amino]-3-[2-(trifluoromethoxy)phenyl]propanoic acid,   (z035) 2-[benzyloxycarbonyl(methyl)amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid,   (z036) 2-[benzyloxycarbonyl(methyl)amino]-3-(2-methoxyphenyl)propanoic acid,   (z037) 2-[benzyloxycarbonyl(methyl)amino]-3-[4-(difluoromethyl)phenyl]propanoic acid,   (z038) 2-[benzyloxycarbonyl(methyl)amino]-3-(2-cyanophenyl)propanoic acid,   (z039) 2-[benzyloxycarbonyl(methyl)amino]-3-[2-(trifluoromethyl)phenyl]propanoic acid,   (z040) 2-[benzyloxycarbonyl(methyl)amino]-3-(4-cyanophenyl)propanoic acid,   (z041) 2-[benzyloxycarbonyl(methyl)amino]-3-(3-cyanophenyl)propanoic acid,   (z042) 3-(benzyloxycarbonylamino)-4-isopentyloxy-butanoic acid,   (z043) 3-(benzyloxycarbonylamino)-4-[2-(tert-butylamino)-2-oxo-ethoxy]butanoic acid,   (z044) 2-(((benzyloxy)carbonyl)amino)-3-(3-iodophenyl)-2-methylpropanoic acid,   (z045) 2-(((benzyloxy)carbonyl)(methyl)amino)-2-methyl-3-phenylpropanoic acid,   (z046) 1-[benzyloxycarbonyl(methyl)amino]cyclopentanecarboxylic acid,   (z047) 1-((benzyloxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid,   (z048) 1-((benzyloxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid,   (z049) 3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(piperidin-1-yl)butanoic acid,   (z050) 3-[benzyloxycarbonyl(propyl)amino]-4-oxo-4-(1-piperidyl)butanoic acid,   (z051) 4-allyloxy-2-[benzyloxycarbonyl(methyl)amino]-4-oxo-butanoic acid,   (z052) 3-[benzyloxycarbonyl(ethyl)amino]-4-oxo-4-(1-piperidyl)butanoic acid,   (z053) 3-[benzyloxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-yl-butanoic acid,   (z054) 3-[benzyloxycarbonyl(methyl)amino]-4-oxazolidin-3-yl-4-oxo-butanoic acid,   (z055) 3-(benzyloxycarbonylamino)-4-oxazolidin-3-yl-4-oxo-butanoic acid,   (z056) 3-[benzyloxycarbonyl(methyl)amino]-4-oxo-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)butanoic acid,   (z057) 3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)butanoic acid,   (z058) 3-(benzyloxycarbonylamino)-4-(3,3,4,4,5,5-hexafluoro-1-piperidyl)-4-oxo-butanoic acid,   (z059) 3-[benzyloxycarbonyl(methyl)amino]-4-(3,3,4,4,5,5-hexafluoro-1-piperidyl)-4-oxo-butanoic acid,   (z060) 3-(((benzyloxy)carbonyl)amino)-4-(3,3-dimethylpyrrolidin-1-yl)-4-oxobutanoic acid,   (z061) 3-(((benzyloxy)carbonyl)amino)-4-(4-methylpiperidin-1-yl)-4-oxobutanoic acid,   (z062) 3-(((benzyloxy)carbonyl)amino)-4-morpholino-4-oxobutanoic acid,   (z063) 3-(((benzyloxy)carbonyl)amino)-4-(1,1-dioxidothiomorpholino)-4-oxobutanoic acid,   (z064) 3-(((benzyloxy)carbonyl)amino)-4-(4-(tert-butyl)piperidin-1-yl)-4-oxobutanoic acid,   (z065) 3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(pyrrolidin-1-yl)butanoic acid,   (z066) 3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(pyrrolidin-1-yl)butanoic acid,   (z067) 3-(benzyloxycarbonylamino)-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxo-butanoic acid,   (z068) 3-(benzyloxycarbonylamino)-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxo-butanoic acid,   (z069) 3-[benzyloxycarbonyl(methyl)amino]-4-(1,1-dioxo-1,4-thiazinan-4-yl)-4-oxo-butanoic acid,   (z070) 3-[benzyloxycarbonyl(methyl)amino]-4-(4-methyl-1-piperidyl)-4-oxo-butanoic acid,   (z071) 3-[benzyloxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-yl-butanoic acid,   (z072) 4-(azetidin-1-yl)-3-[benzyloxycarbonyl(methyl)amino]-4-oxo-butanoic acid,   (z073) 3-[benzyloxycarbonyl(methyl)amino]-4-(dimethylamino)-4-oxo-butanoic acid,   (z074) 3-[benzyloxycarbonyl(methyl)amino]-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxo-butanoic acid,   (z075) 3-[benzyloxycarbonyl(methyl)amino]-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxo-butanoic acid,   (z076) 3-[benzyloxycarbonyl(methyl)amino]-4-(3,3-dimethylpyrrolidin-1-yl)-4-oxo-butanoic acid,   (z077) 3-[benzyloxycarbonyl(methyl)amino]-4-morpholino-4-oxo-butanoic acid,   (z078) 3-(((benzyloxy)carbonyl)(methyl)amino)-4-oxo-4-(piperidin-1-yl)butanoic acid,   (z079) 2-[benzyloxycarbonyl(methyl)amino]-4-(4-pyridyl)butanoic acid,   (z080) 2-[benzyloxycarbonyl(methyl)amino]-4-(3-pyridyl)butanoic acid,   (z081) 2-(((benzyloxy)carbonyl)amino)-3-(5-bromothiophen-2-yl)propanoic acid,   (z082) 2-(((benzyloxy)carbonyl)amino)-3-(5-chlorothiophen-2-yl)propanoic acid,   (z083) 2-[benzyloxycarbonyl(methyl)amino]-3-(3-pyridyl)propanoic acid,   (z084) 2-[benzyloxycarbonyl(methyl)amino]-3-(4-pyridyl)propanoic acid,   (z085) 2-(((benzyloxy)carbonyl)amino)-3-(5-bromopyridin-3-yl)propanoic acid,   (z086) 2-[benzyloxycarbonyl(methyl)amino]-3-(6-methyl-3-pyridyl)propanoic acid,   (z087) 2-[benzyloxycarbonyl(methyl)amino]-3-(6-methoxy-3-pyridyl)propanoic acid,   (z088) 2-[benzyloxycarbonyl(methyl)amino]-3-(5-methyl-3-pyridyl)propanoic acid,   (z089) 2-[benzyloxycarbonyl(methyl)amino]-3-(5-methoxy-3-pyridyl)propanoic acid,   (z090) 2-[benzyloxycarbonyl(methyl)amino]-3-[6-(trifluoromethyl)-3-pyridyl]propanoic acid,   (z091) 2-[benzyloxycarbonyl(methyl)amino]-4-(3,3-difluoroazetidin-1-yl)-4-oxo-butanoic acid,   (z092) 2-[benzyloxycarbonyl(methyl)amino]-4-(4,4-difluoro-1-piperidyl)-4-oxo-butanoic acid,   (z093) 2-[benzyloxycarbonyl(methyl)amino]-4-methylsulfonyl-butanoic acid,   (z094) 2-[benzyloxycarbonyl(methyl)amino]-4-(3,3-difluoroazetidin-1-yl)butanoic acid,   (z095) (2S,3R)-2-[benzyloxycarbonyl(methyl)amino]-3-methoxy-butanoic acid,   (z096) 2-[benzyloxycarbonyl(methyl)amino]-4-methoxy-butanoic acid,   (z097) 2-[benzyloxycarbonyl(methyl)amino]-3-(cyclopropoxy)propanoic acid,   (z098) 2-[benzyloxycarbonyl(methyl)amino]-3-methoxy-propanoic acid,   (z099) 2-[benzyloxycarbonyl(methyl)amino]-3-isopentyloxy-propanoic acid,   (z100) 2-[benzyloxycarbonyl(methyl)amino]-3-hydroxy-propanoic acid,   (z101) 2-[benzyloxycarbonyl(methyl)amino]-3-(2,2,2-trifluoroethoxy)propanoic acid,   (z102) 2-(benzyloxycarbonylamino)-3-(2,2,2-trifluoroethoxy)propanoic acid,   (z103) 2-(benzyloxycarbonylamino)-3-(cyclobutoxy)propanoic acid,   (z104) 2-[benzyloxycarbonyl(methyl)amino]-3-(cyclobutoxy)propanoic acid,   (z105) 2-(benzyloxycarbonylamino)-3-(cyclopropoxy)propanoic acid,   (z106) 2-[benzyloxycarbonyl(methyl)amino]-5,5-difluoro-pentanoic acid,   (z107) 2-[benzyloxycarbonyl(methyl)amino]-4,4,4-trifluoro-butanoic acid,   (z108) 2-[benzyloxycarbonyl(methyl)amino]-2-cyclopropyl-acetic acid,   (z109) 2-[benzyloxycarbonyl(methyl)amino]-2-cyclopentyl-acetic acid,   (z110) 2-[benzyloxycarbonyl(methyl)amino]-2-cyclobutyl-acetic acid,   (z111) 2-[benzyloxycarbonyl(methyl)amino]pent-4-ynoic acid,   (z112) 2-[benzyloxycarbonyl(methyl)amino]hex-5-ynoic acid,   (z113) 2-[benzyloxycarbonyl(methyl)amino]pent-4-enoic acid,   (z114) 3-(((benzyloxy)carbonyl)amino)-5-methylhexanoic acid,   (z115) 2-(((benzyloxy)carbonyl)(methyl)amino)-5-methylhexanoic acid,   (z116) 2-(((benzyloxy)carbonyl)(methyl)amino)octanoic acid,   (z117) 2-[benzyloxycarbonyl(ethyl)amino]-3-cyclohexyl-propanoic acid,   (z118) 2-[benzyloxycarbonyl(ethyl)amino]-4-methyl-pentanoic acid,   (z119)N-((benzyloxy)carbonyl)-N-ethyl-alanine,   (z120) 2-[benzyloxycarbonyl(methyl)amino]heptanoic acid,   (z121) 2-[benzyloxycarbonyl(methyl)amino]-3-cyclobutyl-propanoic acid,   (z122) 2-[benzyloxycarbonyl(methyl)amino]-3-cyclopentyl-propanoic acid,   (z123) 2-[benzyloxycarbonyl(methyl)amino]-3-cyclopropyl-propanoic acid,   (z124) 3-(((benzyloxy)carbonyl)(methyl)amino)-5-methylhexanoic acid,   (z125) 2-[benzyloxycarbonyl(propyl)amino]propanoic acid,   (z126)N-((benzyloxy)carbonyl)-N-isopropylglycine (z127)N-((benzyloxy)carbonyl)-N-cyclopropylglycine (z128) 2-[benzyloxycarbonyl-[2-(4,4-difluoro-1-piperidyl)ethyl]amino]acetic acid,   (z129) 2-[benzyloxycarbonyl-[3-(4,4-difluoro-1-piperidyl)propyl]amino]acetic acid,   (z130) 2-[2-[benzyloxycarbonyl(methyl)amino]-3-(dimethylamino)-3-oxo-propyl]sulfanylacetic acid,   (z131) 2-[2-(azetidin-3-yl)ethyl-benzyloxycarbonyl-amino]acetic acid,   (z132) 2-[2-(2-aminoethoxy)ethyl-benzyloxycarbonyl-amino]acetic acid, and   (z133) 2-[benzyloxycarbonyl-[2-[2-(methylamino)ethoxy]ethyl]amino]acetic acid.   In the present invention, specific examples of the N-protected non-natural amino acid having a Boc group as a protecting group include the following amino acids:   (b001) 2-[tert-butoxycarbonyl(ethyl)amino]-3-[4-(trifluoromethyl)phenyl]propanoic acid,   (b002) 2-(tert-butoxycarbonylamino)-4-[3,5-difluoro-4-(trifluoromethyl)phenyl]butanoic acid,   (b003) 2-(tert-butoxycarbonylamino)-4-[3-fluoro-4-(trifluoromethyl)phenyl]butanoic acid,   (b004) 2-(tert-butoxycarbonylamino)-4-[3-chloro-4-(trifluoromethyl)phenyl]butanoic acid,   (b005) 2-(tert-butoxycarbonylamino)-4-[4-(pentafluoro-_S-sulfanyl)phenyl]butanoic acid,   (b006) 2-[tert-butoxycarbonyl(methyl)amino]-3-(3-iodophenyl)propanoic acid,   (b007) 2-[tert-butoxycarbonyl(methyl)amino]-3-(3,4-difluorophenyl)propanoic acid,   (b008) 2-(tert-butoxycarbonylamino)-3-(5-bromo-2-methyl-phenyl)propanoic acid,   (b009) 2-(tert-butoxycarbonylamino)-3-(5-iodo-2-methyl-phenyl)propanoic acid,   (b010) 2-(tert-butoxycarbonylamino)-3-(2-bromo-5-iodo-phenyl)propanoic acid,   (b011) 2-(tert-butoxycarbonylamino)-3-(2-chloro-5-iodo-phenyl)propanoic acid,   (b012) 2-(tert-butoxycarbonylamino)-3-(2-fluoro-5-iodo-phenyl)propanoic acid,   (b013) 2-(tert-butoxycarbonylamino)-3-(3,5-dichlorophenyl)propanoic acid,   (b014) 2-(tert-butoxycarbonylamino)-3-(2,5-difluorophenyl)propanoic acid,   (b015) 2-(tert-butoxycarbonylamino)-3-(2,6-difluorophenyl)propanoic acid,   (b016) 2-[tert-butoxycarbonyl(ethyl)amino]-3-[4-(trifluoromethyl)phenyl]propanoic acid,   (b017) 2-[tert-butoxycarbonyl(ethyl)amino]-3-(p-tolyl)propanoic acid,   (b018) 2-[tert-butoxycarbonyl(ethyl)amino]-3-(4-chlorophenyl)propanoic acid,   (b019) 2-(tert-butoxycarbonylamino)-3-(3-fluoro-5-iodo-phenyl)propanoic acid,   (b020) 2-(tert-butoxycarbonylamino)-3-(2-fluoro-3-iodo-phenyl)propanoic acid,   (b021) 2-(tert-butoxycarbonylamino)-3-(3-chloro-5-iodo-phenyl)propanoic acid,   (b022) 3-(3-bromophenyl)-2-[tert-butoxycarbonyl(methyl)amino]propanoic acid,   (b023) 2-[tert-butoxycarbonyl(methyl)amino]-3-(4-iodophenyl)propanoic acid,   (b024) 2-[tert-butoxycarbonyl(methyl)amino]-3-(2-fluorophenyl)propanoic acid,   (b025) 2-[tert-butoxycarbonyl(methyl)amino]-3-(2-chlorophenyl)propanoic acid,   (b026) 2-[tert-butoxycarbonyl(methyl)amino]-3-[4-(trifluoromethyl)phenyl]propanoic acid,   (b027) 2-[tert-butoxycarbonyl(methyl)amino]-3-[3-(trifluoromethoxy)phenyl]propanoic acid,   (b028) 3-(4-bromophenyl)-2-[tert-butoxycarbonyl(methyl)amino]propanoic acid,   (b029) 2-[tert-butoxycarbonyl(methyl)amino]-3-(p-tolyl)propanoic acid,   (b030) 2-[tert-butoxycarbonyl(methyl)amino]-3-(4-fluorophenyl)propanoic acid,   (b031) 2-[tert-butoxycarbonyl(methyl)amino]-3-[4-(trifluoromethoxy)phenyl]propanoic acid,   (b032) 2-[tert-butoxycarbonyl(methyl)amino]-3-(3-fluorophenyl)propanoic acid,   (b033) 2-[tert-butoxycarbonyl(methyl)amino]-3-(o-tolyl)propanoic acid,   (b034) 2-[tert-butoxycarbonyl(methyl)amino]-3-[2-(trifluoromethoxy)phenyl]propanoic acid,   (b035) 2-[tert-butoxycarbonyl(methyl)amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid,   (b036) 2-[tert-butoxycarbonyl(methyl)amino]-3-(2-methoxyphenyl)propanoic acid,   (b037) 2-[tert-butoxycarbonyl(methyl)amino]-3-[4-(difluoromethyl)phenyl]propanoic acid,   (b038) 2-[tert-butoxycarbonyl(methyl)amino]-3-(2-cyanophenyl)propanoic acid,   (b039) 2-[tert-butoxycarbonyl(methyl)amino]-3-[2-(trifluoromethyl)phenyl]propanoic acid,   (b040) 2-[tert-butoxycarbonyl(methyl)amino]-3-(4-cyanophenyl)propanoic acid,   (b041) 2-[tert-butoxycarbonyl(methyl)amino]-3-(3-cyanophenyl)propanoic acid,   (b042) 3-(tert-butoxycarbonylamino)-4-isopentyloxy-butanoic acid,   (b043) 3-(tert-butoxycarbonylamino)-4-[2-(tert-butylamino)-2-oxo-ethoxy]butanoic acid,   (b044) 2-(tert-butoxycarbonylamino)-3-(3-iodophenyl)-2-methyl-propanoic acid,   (b045) 2-[tert-butoxycarbonyl(methyl)amino]-2-methyl-3-phenyl-propanoic acid,   (b046) 1-[tert-butoxycarbonyl(methyl)amino]cyclopentanecarboxylic acid,   (b047) 1-tert-butoxycarbonyl-4-hydroxy-pyrrolidine-2-carboxylic acid,   (b048) 1-tert-butoxycarbonyl-4-hydroxy-pyrrolidine-2-carboxylic acid,   (b049) 3-(tert-butoxycarbonylamino)-4-oxo-4-(1-piperidyl)butanoic acid,   (b050) 3-[tert-butoxycarbonyl(propyl)amino]-4-oxo-4-(1-piperidyl)butanoic acid,   (b051) 4-allyloxy-2-I[tert-butoxycarbonyl(methyl)amino]-4-oxo-butanoic acid,   (b052) 3-[tert-butoxycarbonyl(ethyl)amino]-4-oxo-4-(1-piperidyl)butanoic acid,   (b053) 3-[tert-butoxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-yl-butanoic acid,   (b054) 3-[tert-butoxycarbonyl(methyl)amino]-4-oxazolidin-3-yl-4-oxo-butanoic acid,   (b055) 3-(tert-butoxycarbonylamino)-4-oxazolidin-3-yl-4-oxo-butanoic acid,   (b056) 3-[tert-butoxycarbonyl(methyl)amino]-4-oxo-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)butanoic acid,   (b057) 3-(tert-butoxycarbonylamino)-4-(3,3,4,4,5,5-hexafluoro-1-piperidyl)-4-oxo-butanoic acid,   (b058) 3-(tert-butoxycarbonylamino)-4-(3,3,4,4,5,5-hexafluoro-1-piperidyl)-4-oxo-butanoic acid,   (b059) 3-[tert-butoxycarbonyl(methyl)amino]-4-(3,3,4,4,5,5-hexafluoro-1-piperidyl)-4-oxo-butanoic acid,   (b060) 3-(tert-butoxycarbonylamino)-4-(3,3-dimethylpyrrolidin-1-yl)-4-oxo-butanoic acid,   (b061) 3-(tert-butoxycarbonylamino)-4-(4-methyl-1-piperidyl)-4-oxo-butanoic acid,   (b062) 3-(tert-butoxycarbonylamino)-4-morpholino-4-oxo-butanoic acid,   (b063) 3-(tert-butoxycarbonylamino)-4-(1,1-dioxo-1,4-thiazinan-4-yl)-4-oxo-butanoic acid,   (b064) 3-(tert-butoxycarbonylamino)-4-(4-tert-butyl-1-piperidyl)-4-oxo-butanoic acid,   (b065) 3-(tert-butoxycarbonylamino)-4-(dimethylamino)-4-oxo-butanoic acid,   (b066) 3-(tert-butoxycarbonylamino)-4-oxo-4-pyrrolidin-1-yl-butanoic acid,   (b067) 3-(tert-butoxycarbonylamino)-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxo-butanoic acid,   (b068) 3-(tert-butoxycarbonylamino)-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxo-butanoic acid,   (b069) 3-[tert-butoxycarbonyl(methyl)amino]-4-(1,1-dioxo-1,4-thiazinan-4-yl)-4-oxo-butanoic acid,   (b070) 3-[tert-butoxycarbonyl(methyl)amino]-4-(4-methyl-1-piperidyl)-4-oxo-butanoic acid,   (b071) 3-[tert-butoxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-yl-butanoic acid,   (b072) 4-(azetidin-1-yl)-3-[tert-butoxycarbonyl(methyl)amino]-4-oxo-butanoic acid,   (b073) 3-[tert-butoxycarbonyl(methyl)amino]-4-(dimethylamino)-4-oxo-butanoic acid,   (b074) 3-[tert-butoxycarbonyl(methyl)amino]-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxo-butanoic acid,   (b075) 3-[tert-butoxycarbonyl(methyl)amino]-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxo-butanoic acid,   (b076) 3-[tert-butoxycarbonyl(methyl)amino]-4-(3,3-dimethylpyrrolidin-1-yl)-4-oxo-butanoic acid,   (b077) 3-[tert-butoxycarbonyl(methyl)amino]-4-morpholino-4-oxo-butanoic acid,   (b078) 3-[tert-butoxycarbonyl(methyl)amino]-4-oxo-4-(1-piperidyl)butanoic acid,   (b079) 2-[tert-butoxycarbonyl(methyl)amino]-4-(4-pyridyl)butanoic acid,   (b080) 2-[tert-butoxycarbonyl(methyl)amino]-4-(3-pyridyl)butanoic acid,   (b081) 2-(tert-butoxycarbonylamino)-3-(5-bromo-2-thienyl)propanoic acid,   (b082) 2-(tert-butoxycarbonylamino)-3-(5-chloro-2-thienyl)propanoic acid,   (b083) 2-[tert-butoxycarbonyl(methyl)amino]-3-(3-pyridyl)propanoic acid,   (b084) 2-[tert-butoxycarbonyl(methyl)amino]-3-(4-pyridyl)propanoic acid,   (b085) 2-(tert-butoxycarbonylamino)-3-(5-bromo-3-pyridyl)propanoic acid,   (b086) 2-[tert-butoxycarbonyl(methyl)amino]-3-(6-methyl-3-pyridyl)propanoic acid,   (b087) 2-[tert-butoxycarbonyl(methyl)amino]-3-(6-methoxy-3-pyridyl)propanoic acid,   (b088) 2-[tert-butoxycarbonyl(methyl)amino]-3-(5-methyl-3-pyridyl)propanoic acid,   (b089) 2-[tert-butoxycarbonyl(methyl)amino]-3-(5-methoxy-3-pyridyl)propanoic acid,   (b090) 2-[tert-butoxycarbonyl(methyl)amino]-3-[6-(trifluoromethyl)-3-pyridyl]propanoic acid,   (b091) 2-[tert-butoxycarbonyl(methyl)amino]-4-(3,3-difluoroazetidin-1-yl)-4-oxo-butanoic acid,   (b092) 2-[tert-butoxycarbonyl(methyl)amino]-4-(4,4-difluoro-1-piperidyl)-4-oxo-butanoic acid,   (b093) 2-[tert-butoxycarbonyl(methyl)amino]-4-methylsulfonyl-butanoic acid,   (b094) 2-[tert-butoxycarbonyl(methyl)amino]-4-(3,3-difluoroazetidin-1-yl)butanoic acid,   (b095) (2S,3R)-2-[tert-butoxycarbonyl(methyl)amino]-3-methoxy-butanoic acid,   (b096) 2-[tert-butoxycarbonyl(methyl)amino]-4-methoxy-butanoic acid,   (b097) 2-[tert-butoxycarbonyl(methyl)amino]-3-(cyclopropoxy)propanoic acid,   (b098) 2-[tert-butoxycarbonyl(methyl)amino]-3-methoxy-propanoic acid,   (b099) 2-[tert-butoxycarbonyl(methyl)amino]-3-isopentyloxy-propanoic acid,   (b100) 2-[tert-butoxycarbonyl(methyl)amino]-3-hydroxy-propanoic acid,   (b101) 2-[tert-butoxycarbonyl(methyl)amino]-3-(2,2,2-trifluoroethoxy)propanoic acid,   (b102) 2-(tert-butoxycarbonylamino)-3-(2,2,2-trifluoroethoxy)propanoic acid,   (b103) 2-(tert-butoxycarbonylamino)-3-(cyclobutoxy)propanoic acid,   (b104) 2-[tert-butoxycarbonyl(methyl)amino]-3-(cyclobutoxy)propanoic acid,   (b105) 2-(tert-butoxycarbonylamino)-3-(cyclopropoxy)propanoic acid,   (b106) 2-[tert-butoxycarbonyl(methyl)amino]-5,5-difluoro-pentanoic acid,   (b107) 2-[tert-butoxycarbonyl(methyl)amino]-4,4,4-trifluoro-butanoic acid,   (b108) 2-[tert-butoxycarbonyl(methyl)amino]-2-cyclopropyl-acetic acid,   (b109) 2-[tert-butoxycarbonyl(methyl)amino]-2-cyclopentyl-acetic acid,   (b110) 2-[tert-butoxycarbonyl(methyl)amino]-2-cyclobutyl-acetic acid,   (b111) 2-[tert-butoxycarbonyl(methyl)amino]pent-4-ynoic acid,   (b112) 2-[tert-butoxycarbonyl(methyl)amino]hex-5-ynoic acid,   (b113) 2-[tert-butoxycarbonyl(methyl)amino]pent-4-enoic acid,   (b114) 3-(tert-butoxycarbonylamino)-5-methyl-hexanoic acid,   (b115) 2-[tert-butoxycarbonyl(methyl)amino]-5-methyl-hexanoic acid,   (b116) 2-[tert-butoxycarbonyl(methyl)amino]octanoic acid,   (b117) 2-[tert-butoxycarbonyl(ethyl)amino]-3-cyclohexyl-propanoic acid,   (b118) 2-[tert-butoxycarbonyl(ethyl)amino]-4-methyl-pentanoic acid,   (b119) 2-[tert-butoxycarbonyl(ethyl)amino]propanoic acid,   (b120) 2-[tert-butoxycarbonyl(methyl)amino]heptanoic acid,   (b121) 2-[tert-butoxycarbonyl(methyl)amino]-3-cyclobutyl-propanoic acid,   (b122) 2-[tert-butoxycarbonyl(methyl)amino]-3-cyclopentyl-propanoic acid,   (b123) 2-[tert-butoxycarbonyl(methyl)amino]-3-cyclopropyl-propanoic acid,   (b124) 3-[tert-butoxycarbonyl(methyl)amino]-5-methyl-hexanoic acid,   (b125) 2-[tert-butoxycarbonyl(propyl)amino]propanoic acid,   (b126) 2-[tert-butoxycarbonyl(isopropyl)amino]acetic acid,   (b127) 2-[tert-butoxycarbonyl(cyclopropyl)amino]acetic acid,   (b128) 2-[tert-butoxycarbonyl-[2-(4,4-difluoro-1-piperidyl)ethyl]amino]acetic acid,   (b129) 2-[tert-butoxycarbonyl-[3-(4,4-difluoro-1-piperidyl)propyl]amino]acetic acid,   (b130) 2-[2-[tert-butoxycarbonyl(methyl)amino]-3-(dimethylamino)-3-oxo-propyl]sulfanylacetic acid,   (b131) 2-[2-(azetidin-3-yl)ethyl-tert-butoxycarbonyl-amino]acetic acid,   (b132) 2-[2-(2-aminoethoxy)ethyl-tert-butoxycarbonyl-amino]acetic acid, and   (b133) 2-[tert-butoxycarbonyl-[2-[2-(methylamino)ethoxy]ethyl]amino]acetic acid.   

     (General Production Method) 
     General production methods for the cyclic peptide compound, and the non-natural amino acid for use in the production of the cyclic peptide compound of the present invention will be described below. 
     Chemical Synthesis Methods for Peptide Compounds 
     Examples of chemical synthesis methods for the peptide compounds or the cyclic peptide compounds herein include a liquid-phase synthesis method, a solid-phase synthesis method using Fmoc synthesis, Boc synthesis, or the like, and a combination thereof. In Fmoc synthesis, a basic unit is an amino acid in which a main-chain amino group is protected with an Fmoc group, and a side-chain functional group is protected as necessary with piperidine or a protecting group that is not cleaved by a base, such as a t-Bu group, a THP group, or a Trt group, and a main-chain carboxylic acid is not protected. The basic unit is not particularly limited as long as it is a combination having an Fmoc-protected amino group and a carboxyl group. For example, dipeptide may be a basic unit. The basic unit disposed at the N terminus may be a unit other than the Fmoc amino acid. For example, it may be a Boc amino acid or a carboxylic acid analog which does not have an amino group. The main-chain carboxyl group, or a side-chain carboxyl group of an amino acid that has a carboxyl group in a side chain and in which the main-chain carboxyl group is protected with a suitable protecting group, is supported on a solid phase by a chemical reaction with the functional group of a solid-phase carrier. Subsequently, the Fmoc group is deprotected by a base such as piperidine or DBU, and a newly produced amino group and a subsequently added, basic-unit protected amino acid having a carboxyl group are subjected to a condensation reaction to produce a peptide bond. In the condensation reaction, various combinations such as a combination of DIC and HOBt, a combination of DIC and HOAt, and a combination of HATU and DIPEA are possible as activating agents for the carboxyl group. The desired peptide sequence can be produced by repeating the Fmoc group deprotection and the subsequent peptide bond forming reaction. After the desired sequence is obtained, cleavage from the solid phase and deprotection of the optionally introduced protecting group of the side-chain functional group are conducted. Further, conformational conversion and cyclization of the peptide can be performed before cleaving from the solid phase. Cleaving from the solid phase and deprotection may be performed under the same conditions, e.g., in 90:10 TFA/H 2 O, or deprotection may be performed under different conditions as necessary. Cleaving from the solid phase may be achieved using a weak acid such as 1% TFA in some cases, and Pd or the like may be used as a protecting group to utilize the orthogonality of both chemical reactions. During or at the end of these steps, a step such as cyclization can also be performed. For example, a side-chain carboxylic acid and an N-terminal main-chain amino group can be condensed, and a side-chain amino group and a C-terminal main-chain carboxylic acid can be condensed. In this case, reaction orthogonality is required between the carboxylic acid on the C-terminal side and the side-chain carboxylic acid to be cyclized, or between the main-chain amino group or hydroxy group on the N-terminal side and the side-chain amino group to be cyclized. As described above, the protecting group is selected in consideration of the orthogonality of the protecting group. The reaction product thus obtained can be purified by a reverse-phase column, a molecular sieve column, or the like. Details of these procedures are described in, for example, the Solid-Phase Synthesis Handbook published by Merck on May 1, 2002. Commercially available resins for solid phase synthesis are usable, and examples include CTC resin, Wang resin, and SASRIN resin. 
     A general method for synthesizing an amino acid-supported resin for use in peptide synthesis by a peptide synthesizer will be described below. 
     An Fmoc amino acid can be supported on a resin by the method described in WO2013/100132 or WO2018/225864. Specifically, for example, 2-chlorotrityl chloride resin and a solvent (e.g., dehydrated dichloromethane) are introduced into a filter-equipped reaction vessel to swell the resin. Next, the solvent and the resin are separated, and then a mixture of the resin, a C-terminal free Fmoc amino acid dissolved in a solvent (e.g., dehydrated dichloromethane), a solvent (e.g., dehydrated methanol), and a base (e.g., diisopropylethylamine) is added to the reaction vessel and mixed to support the Fmoc amino acid on the resin. After the resin and the reaction solution are separated, the resin is mixed with a mixture of one or more solvents and a base (e.g., a mixture of dehydrated dichloromethane, dehydrated methanol, and diisopropylethylamine) to wash the resin. After the resin is washed with a solvent (e.g., dichloromethane) multiple times as necessary, the resin and the reaction solution are separated. By drying the resulting resin under reduced pressure overnight, an Fmoc amino acid-supported resin can be obtained. 
     
       
         
         
             
             
         
       
     
     (wherein n represents an integer of 1 to 11; P 1  to P 11 , Q 1  to Q 11 , and R 1  to R 11  mean P 1  to P 11 , Q 1  to Q 11 , and R 1  to R 11  as defined herein, respectively; L 1  and L 11  mean L 1  and L 11  as described herein, respectively; L 2  to L 10  are single bonds; and ∘ (circle) means a resin portion.) 
     The above structure shows that in the Fmoc-amino acid, the 2-chlorotrityl group on the resin is bonded to the carboxylic acid of the Fmoc amino acid via an ester bond. 
     In the production of the compound described herein, when the defined group undergoes undesired chemical conversion under the conditions of the performed method, the compound can be produced by means of, for example, protection and deprotection of a functional group. Selection and introduction/removal procedures of a protecting group can be performed according to, for example, the methods described in Greene&#39;s “Protective Groups in Organic Synthesis” (5th Ed., John Wiley &amp; Sons, 2014), which may be suitably used depending on the reaction conditions. Further, the order of reaction steps such as introduction of a substituent can be changed as necessary. For example, the protecting group for an amino group is an Fmoc, Boc, Cbz, or Alloc group. These carbamate groups can be introduced by reacting an amino group with a carbamating agent in the presence of a basic catalyst. Examples of the carbamating agent include Boc 2 O, BocOPh, FmocOSu, FmocCl, CbzCl, and AllocCl. Examples of the basic catalyst include lithium carbonate, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, cesium carbonate, cesium hydrogen carbonate, lithium hydroxide, sodium hydroxide, potassium hydroxide, cesium hydroxide, sodium phosphate, potassium phosphate, N-methylmorpholine, triethylamine, diisopropylethylamine, and N,N-dimethylaminopyridine. A carbamate group which is a protecting group for an amino group can be removed under basic conditions, acidic conditions, hydrogenolysis reaction conditions, or the like. 
     (Cyclization Methods for Cyclic Peptide Compounds) 
     A method for transforming a linear peptide compound into a cyclic peptide compound can be performed by carrying out a bond forming reaction within the molecule according to, for example, the method described in Comprehensive Organic Transformations, A Guide to Functional Group Preparations, 3rd Edition by R. C. Larock, or March&#39;s Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 7th Edition by M. B. March. After the bond forming reaction, further, a functional group transforming reaction can also be performed. Examples of the bond forming reaction include a C(O)—N bond formed from carboxylic acid and amine; a C—O—C bond, a C(O)—O bond, and a C(S)—O bond using an oxygen atom; a C(O)—S bond, a C(S)—S bond, a C—S—S—C bond, a C—S—C bond, a C—S(O)—C bond, and a C—S(O 2 )—C bond using a sulfur atom; and a C—N—C bond, a C═N—C bond, an N—C(O)—N bond, an N—C(S)N bond, and a C(S)—N bond using a nitrogen atom. Furthermore, examples include C—C bond forming reactions catalyzed by a transition metal, such as Suzuki reaction, Heck reaction, and Sonogashira reaction. Examples of the functional group transforming reaction further performed after the bond forming reaction include an oxidation reaction and a reduction reaction. A specific example is a reaction for oxidizing a sulfur atom to transform it into a sulfoxide group or a sulfone group. Another example is a reduction reaction for reducing a triple bond or a double bond of carbon-carbon bonds to a double bond or a single bond. While a closed ring structure is formed by a peptide bond when two amino acids are bonded with the amino acid main chain, a covalent bond between two amino acids may be formed by bonding between side chains of two amino acids, bonding between a side chain and a main chain, or the like. A black circle or a black square below indicates an amino acid residue, and connected black circles or black squares represent a peptide chain connected by an amide bond. The number of amino acid residues constituting a peptide chain are not particularly limited, and the number of black circles or black squares below does not represent the number of amino acid residues. 
     Herein, a peptide compound having a cyclic moiety may be referred to as a “cyclic peptide compound”. Herein, the “cyclic moiety” of a peptide compound means a cyclic portion formed of two or more connected amino acid residues. 
     (General Preparation Method 1 for Cyclic Peptide Compounds) 
     
       
         
         
             
             
         
       
     
     Cyclic moieties of cyclic peptide compounds having linear moieties can be cyclized by activating the N-terminal amino group and the C-terminal side chain carboxyl group (e.g., L=—CH 2 — in the case of aspartic acid or its derivative, and L=—CH 2 CH 2 — in the case of glutamic acid or its derivative) with an activating reagent or converting them to active esters, and then condensing them in the molecule to form a C(O)—N bond. 
     (General Preparation Method 2 for Cyclic Peptide Compounds) 
     
       
         
         
             
             
         
       
     
     Cyclic peptide compounds described in “General preparation method 1 for cyclic peptide compounds” in which the linear moiety is C-Term can be cyclized by activating the N-terminal amino group and the C-terminal side chain carboxyl group (e.g., L=—CH 2 — in the case of aspartic acid or its derivative, and L=—CH 2 CH 2 — in the case of glutamic acid or its derivative) with an activating reagent or converting them to active esters, and then condensing them in the molecule to form a C(O)—N bond. 
     (General Preparation Method 3 for Cyclic Peptide Compounds) 
     (Method of Cyclizing with Haloalkyl and SH Groups) 
     
       
         
         
             
             
         
       
     
     Cyclic moieties of cyclic peptide compounds having linear moieties can be cyclized by reacting the haloalkyl group of an amino acid residue with the thiol group of an amino acid residue in the molecule to form a C—S—C bond. Cyclic peptide compounds described in “General preparation method 1 for cyclic peptide compounds” in which the linear moiety is C-Term can also be similarly cyclized by reacting the haloalkyl group of an amino acid residue with the thiol group of an amino acid residue in the molecule to form a C—S—C bond. Further, a C—S(O)—C or C—S(O) 2 —C bond can also be formed by oxidizing and converting a sulfur atom to a sulfoxide or sulfone. 
     (Method of Cyclizing with Vinyl and SH Groups) 
     
       
         
         
             
             
         
       
     
     Cyclic moieties of cyclic peptide compounds having linear moieties can be cyclized by reacting the vinyl group of an amino acid residue with the thiol group of an amino acid residue in the molecule to form a C—S—C bond. Cyclic peptide compounds described in “General preparation method 1 for cyclic peptide compounds” in which the linear moiety is C-Term can also be similarly cyclized by reacting the vinyl group of an amino acid residue with the thiol group of an amino acid residue in the molecule to form a C—S—C bond. Further, a C—S(O)—C or C—S(O) 2 —C bond can also be formed by oxidizing and converting a sulfur atom to a sulfoxide or sulfone. 
     (Method of Cyclizing with Ethynyl and SH Groups) 
     
       
         
         
             
             
         
       
     
     Cyclic Moieties of Cyclic Peptide Compounds Having Linear Moieties can be Cyclized by reacting the ethynyl group of an amino acid residue with the thiol group of an amino acid residue in the molecule to form a C—S—C bond. Cyclic peptide compounds described in “General preparation method 1 for cyclic peptide compounds” in which the linear moiety is C-Term can also be similarly cyclized by reacting the ethynyl group of an amino acid residue with the thiol group of an amino acid residue in the molecule to form a C—S—C bond. Further, a C—S(O)—C or C—S(O) 2 —C bond can also be formed by oxidizing and converting a sulfur atom to a sulfoxide or sulfone. The double bond site can also be reduced and converted to a single bond.
 
(Method of Cyclizing with Vinyl and Vinyl Groups)
 
     
       
         
         
             
             
         
       
     
     Cyclic moieties of cyclic peptide compounds having linear moieties can be cyclized by reacting different vinyl groups of amino acid residues with each other in the molecule to form a C—C bond. Cyclic peptide compounds described in “General preparation method 1 for cyclic peptide compounds” in which the linear moiety is C-Term can also be similarly cyclized by reacting different vinyl groups of amino acid residues with each other in the molecule to form a C—C bond. 
     (Method of Cyclizing by Forming a Triazole Ring with Azido and Ethynyl Groups) 
     
       
         
         
             
             
         
       
     
     Cyclic moieties of cyclic peptide compounds having linear moieties can be cyclized by reacting the azido group of an amino acid residue with the ethynyl group of an amino acid residue in the molecule to form a triazole ring. Cyclic peptide compounds described in “General preparation method 1 for cyclic peptide compounds” in which the linear moiety is C-Term can also be similarly cyclized by reacting the azido group of an amino acid residue with the ethynyl group of an amino acid residue in the molecule to form a triazole ring. 
     General preparation methods for peptide compounds by peptide modification are shown below. In the following schemes, P n  represents a substituent for a nitrogen atom, R n  and Q n  each represent an amino acid side chain, a black circle represents an amino acid residue, linked black circles represent a peptide chain linked by amide bonds, and m represents the number of amino acid residues and may be any integer of 1 or more. 
     (Method of Preparing Peptides Containing N-Alkylamino Acids) 
     Peptides containing N-alkylamino acids can be synthesized according to the general peptide synthesis method described in the present Examples using an Fmoc-protected N-alkylamino acid as a raw material, or alternatively can be prepared by alkylating the N-terminal nitrogen on a resin as illustrated below. Specifically, the target peptides having an N-alkylamino acid at the N-terminus can be prepared by reacting the nitrogen of the N-terminal Tfa amide (trifluoroacetamide) of a resin-loaded peptide with an alkyl halide under basic conditions, and then treating the peptide with a reducing agent by referring to Organic Letters, 2008, 10, 4815-4818 or the like. Further, cyclic peptide compounds can be prepared by elongating, cleaving from the resin, cyclizing, deprotecting, and purifying the peptide according to the general peptide synthesis method described in the present Examples. 
     
       
         
         
             
             
         
       
     
     The method described in Nature Protocols, 2012, 7, 432-444 which is shown below can also be used as another method of introducing P n  onto the N-terminal nitrogen. Specifically, the target peptides having P n  at the N-terminus can be obtained by converting the N-terminal amine of a resin-loaded peptide to an Ns-substituted form, introducing P n  by Mitsunobu reaction, and then deprotecting the Ns group. Further, cyclic peptide compounds can be prepared by elongating, cleaving from the resin, cyclizing, deprotecting, and purifying the peptide according to the general peptide synthesis method described in the present Examples. 
     
       
         
         
             
             
         
       
     
     Peptides containing glycine with P n  introduced onto the nitrogen atom can be synthesized according to the general peptide synthesis method described in the present Examples using glycine with P n  introduced onto the Fmoc-protected nitrogen atom as a raw material, or alternatively can be prepared by substitution reaction between the N-terminal halogenated carbon and an amine as illustrated below. Specifically, the target peptides having N-terminal glycine with P n  introduced onto the nitrogen atom can be obtained by reacting the N-terminal amine with iodoacetic acid and then reacting it with any primary amine by referring to Organic Letters, 2010, 12, 4928-4931 or the like. Further, cyclic peptide compounds can be prepared by elongating, cleaving from the resin, cyclizing, deprotecting, and purifying the peptide according to the general peptide synthesis method described in the present Examples. 
     
       
         
         
             
             
         
       
     
     (Method of Preparing Peptides Containing an Aryloxy or Heteroaryloxy Group on the Side Chain) 
     Peptides containing an aryloxy or heteroaryloxy group on the side chain can be prepared according to the general peptide synthesis method described in the present Examples using an Fmoc amino acid having the target aryloxy or heteroaryloxy group on the side chain as a raw material, or alternatively can be prepared using a peptide having an alcohol on the side chain as a precursor by referring to Organic Letters, 2014, 16, 4944-4947, Tetrahedron Letters, 2003, 44, 3863-3865, or the like, as illustrated below. Specifically, peptides having an aryloxy or heteroaryloxy group on the side chain can be prepared by reacting a peptide having an alcohol on the side chain with triarylboroxane-pyridine complex in the presence of copper(II) acetate. n below represents the number of methylene groups and may be any integer of 1 or more. 
     
       
         
         
             
             
         
       
     
     Peptides having an ether group excluding an aryloxy or heteroaryloxy group on the side chain can be prepared according to the general peptide synthesis method described in the present Examples using an Fmoc amino acid having the target ether group on the side chain as a raw material, or alternatively can be prepared using a peptide having an alcohol on the side chain as a precursor by referring to the method described in Journal of Medicinal Chemistry, 2011, 54, 4815-4830 or Journal of Medicinal Chemistry, 2014, 57, 159-170, as illustrated below. Specifically, the peptides having the target ether group on the side chain can be prepared by reacting a peptide having an alcohol with an etherification agent (such as an alkyl halide) in the presence of silver(I) oxide, or by reacting a peptide having an alcohol with an etherification agent (such as an alkyl halide) using an aqueous sodium hydroxide solution as a base in the presence of a phase transfer catalyst such as a tetraalkylammonium salt. 
     
       
         
         
             
             
         
       
     
     (Method of Preparing Peptides Containing an Aryl or Heteroaryl Group on the Side Chain) 
     Peptides having an aryl or heteroaryl group on the side chain can be prepared according to the general peptide synthesis method described in the present Examples using an Fmoc amino acid having the target aryl or heteroaryl group on the side chain as a raw material, or alternatively can be prepared using a peptide having a carboxylic acid on the side chain as a precursor by referring to the method described in J. Am. Chem. Soc., 2016, 138, 5016-5019 or the like, as illustrated below. Specifically, the peptides having the target aryl or heteroaryl group on the side chain can be prepared by activating a peptide having a carboxylic acid on the side chain with N-hydroxyphthalimide, and reacting it with any aryl halide or heteroaryl halide. n below represents the number of methylene groups and may be any integer of 1 or more. 
     
       
         
         
             
             
         
       
     
     Alternatively, peptides having an aryl or heteroaryl group on the side chain can also be synthesized by Suzuki coupling using a peptide having a boronic acid on the side chain as a precursor, as illustrated below. Specifically, the target peptides having an aromatic ring on the side chain can be prepared by synthesizing a precursor peptide using an Fmoc amino acid having a boronic acid on the side chain as a raw material, and reacting it with any aryl halide in the presence of a palladium catalyst. 
     
       
         
         
             
             
         
       
     
     (Method of Preparing Peptides Containing an Amido Group on the Side Chain) 
     Peptides having an amido group on the side chain can be synthesized using an Fmoc amino acid having the target amido group on the side chain as a raw material, or alternatively can be synthesized by amidation of a peptide having a carboxylic acid on the side chain as a precursor, as illustrated below. Specifically, the target peptides having an amido group on the side chain can be obtained by deprotecting a peptide having a protected carboxylic acid on the side chain to synthesize a precursor peptide having a carboxylic acid on the side chain, and condensing it with any amine using a condensing agent such as HATU. n below represents the number of methylene groups and may be any integer of 1 or more. 
     
       
         
         
             
             
         
       
     
     (Synthesis of Peptides Containing a Double Bond on the Side Chain) 
     Peptides having a double bond on the side chain can be synthesized using an Fmoc amino acid having the target double bond on the side chain as a raw material, or alternatively can be prepared by functionalization of a terminal olefin. Specifically, a peptide having a terminal olefin on the side chain can be synthesized according to the general peptide synthesis method described in the present Examples, and the side chain can be further converted to a side chain having a highly substituted olefin by coupling with a substrate having any terminal olefin by olefin metathesis reaction. Further, the side chain can be converted to a corresponding side chain by reducing the olefin by hydrogenation reaction. n below represents the number of methylene groups and may be any integer of 1 or more. 
     
       
         
         
             
             
         
       
     
     Peptide compounds with a peptide backbone crosslinked can also be prepared using a peptide having multiple double bonds on the side chain. Specifically, crosslinked compounds can be prepared by synthesizing a peptide having terminal olefins at two sites on the side chain according to the general peptide synthesis method described in the present Examples, and further crosslinking the two olefins by olefin metathesis reaction by referring to Nature Protocols, 2011, 6, 761-771. Further, compounds crosslinked with saturated alkylenes can be prepared by reducing the olefins by hydrogenation reaction. m and n below represent the number of methylene groups and may be independently any integer of 1 or more. 
     
       
         
         
             
             
         
       
     
     (Synthesis of Peptides Containing a Triazole on the Side Chain) 
     Peptides having a triazole on the side chain can be prepared by click reaction with an azido group. Specifically, peptide compounds having an azido group on the side chain can be prepared by synthesizing a peptide having an azido group on the side chain according to the general peptide synthesis method described in the present Examples, and coupling the peptide with any acetylene in the presence of copper(I) iodide by referring to Bioorganic &amp; Medicinal Chemistry Letters, 2009, 19, 4130-4133 or the like. n below represents the number of methylene groups and may be any integer of 1 or more. 
     
       
         
         
             
             
         
       
     
     (Synthesis of Peptides Containing an Aryl Group Substituted with an Alkynyl Group on the Side Chain) 
     Peptides containing an aryl group substituted with an alkynyl group on the side chain can be synthesized by Sonogashira coupling reaction with an aryl halide group. Specifically, the conversion to peptide compounds having an aryl group substituted with an alkynyl group on the side chain can be conducted by synthesizing a peptide having an aryl iodide group on the side chain according to the general peptide synthesis method described in the present Examples, and coupling the peptide with any acetylene in the presence of copper(I) iodide. n below represents the number of methylene groups and may be any integer of 1 or more. 
     
       
         
         
             
             
         
       
     
     (General Preparation Methods for Non-Natural Amino Acids) 
     General preparation methods for C-terminal-free non-natural amino acids where the nitrogen atoms of the amino acids are protected are shown below. In the following schemes, PG 1  and PG 1 ′ each represent a protecting group for a nitrogen atom, PG 2  and PG 2 ′ each represent a protecting group for an oxygen atom, PG 3  and PG 4  each represent a protecting group for an amino acid side chain, R n  and Q n  each represent an amino acid side chain, P n  represents a substituent for a nitrogen atom, P′ represents C 1 -C 5  alkyl, and R, R′, R″, and R′″ each represent a substituent for a hydrogen or amino group. In the methods of preparing amino acids shown below, a functional group other than the target functional group may cause chemical reaction. In such a case, only the desired reaction can be allowed to proceed by introducing a protecting group onto a non-target functional group. Examples of such protecting group introduction and removal reactions include methods described in Greene&#39;s “Protective Groups in Organic Synthesis” (5th ed., John Wiley &amp; Sons 2014). For conversion reactions of compound functional groups, one can refer to Larock&#39;s “Comprehensive Organic Transformations: A Guide to Functional Group Preparations” (5th ed.) or Smith&#39;s “March&#39;s Advanced Organic Chemistry: Reactions, Mechanisms, and Structure” (8th ed.). 
     Non-natural amino acids having a protecting group (PG 1 ) introduced onto the amino acid nitrogen atom can be prepared using the following method. The target C-terminal-free non-natural amino acids can be prepared by introducing a protecting group onto an N-terminal-free amino acid available from a commercial supplier and deprotecting it as necessary according to conventional methods. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having a protecting group (PG 1 ′) introduced onto the amino acid nitrogen atom can be prepared using the following method. The target C-terminal-free non-natural amino acids can be prepared by deprotecting an amino acid that has a protecting group (PG 1 ) introduced onto the N-terminus which is available from a commercial supplier, and introducing a protecting group, according to conventional methods. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having an aminoalkyl group introduced onto the substituent (Pa) of the amino acid nitrogen atom can be prepared using the following method. A bromoacetic acid ester derivative available from a commercial supplier is reacted with an amino alcohol according to the method of King et al. (Tetrahedron Letters, 2002, 43(11), 1987-1990), and then a protecting group (PG 1 ) is introduced onto the nitrogen atom. Next, the hydroxyl group is oxidized according to the method of Dess et al. (J. Org. Chem., 1983, 48(22), 4155-4156), and the aldehyde group is reductively aminated according to the method of Borch et al. (J. Org. Chem. 1972, 37(10), 1673-1674) to introduce an amino group. Next, the target C-terminal-free non-natural amino acid can be prepared by deprotecting the protecting group for the oxygen atom. 
     
       
         
         
             
             
         
       
     
     N-substituted amino acids can also be prepared by the following scheme of introducing a substituent (P n ) onto the amino acid nitrogen atom. A bromoacetic acid ester derivative available from a commercial supplier is reacted with an amine (P n NH 2 ) in the presence of a base, and then a protecting group (PG 1 ) is introduced onto the nitrogen atom. Next, the target C-terminal-free non-natural amino acid can be prepared by deprotecting the protecting group for the oxygen atom. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having a —CH 2 —P′ group introduced onto the amino acid nitrogen atom can be prepared according to the following scheme. An oxazolidinone compound having an introduced cyclic protecting group can be obtained by allowing an aldehyde to act on a C-terminal-free amino acid available from a commercial supplier according to the method of Freidinger et al. (J. Org. Chem., 1983, 48(1), 77-81). Next, the target C-terminal-free non-natural amino acid can be prepared by ring-opening reaction. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having a P n  group introduced onto the amino acid nitrogen atom can be prepared according to the following scheme. The P n  group can be introduced onto a commercially available C-terminal-free amino acid by allowing an alkylating agent (P n —X) to act on it in the presence of a base. Next, a C-terminal-free non-natural amino acid can be prepared by deprotecting the C-terminal protecting group. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having an amido group introduced onto the amino acid side chain can be prepared according to the following scheme. An amido group can be introduced onto the side chain by deprotecting a commercially available protected amino acid (n=1 or 2) and allowing an amine (R″R′″NH) to act on the resulting carboxylic acid. Next, a C-terminal-free non-natural amino acid can be prepared by deprotecting the C-terminal protecting group. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having an amido group introduced onto the amino acid side chain and a —CH 2 —P′ group introduced onto the amino acid nitrogen atom can be prepared according to the following scheme. An oxazolidinone compound having an introduced cyclic protecting group can be obtained by allowing an aldehyde to act on a commercially available protected amino acid (n=1 or 2) according to the method of Freidinger et al. (J. Org. Chem., 1983, 48(1), 77-81). Next, an amide compound can be obtained by deprotecting the side-chain protecting group and then allowing an amine (R″R′″NH) to act on it. Next, the target C-terminal-free non-natural amino acid can be prepared by ring-opening reaction. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having an amino group introduced onto the amino acid side chain can be prepared according to the following scheme. An amido group can be introduced onto the side chain by allowing an amine (R″R′″NH) to act on the carboxyl group of a commercially available protected amino acid (n=1 or 2). Next, a C-terminal-free non-natural amino acid can be prepared by conducting reduction reaction according to the method of Reeves et al. (Advanced Synthesis &amp; Catalysis, 2013, 355(1), 47-52) and then deprotecting the C-terminal protecting group. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having an amino group introduced onto the amino acid side chain and a —CH 2 —P′ group introduced onto the amino acid nitrogen atom can be prepared according to the following scheme. An amido group can be introduced onto the side chain by allowing an amine (R″R′″NH) to act on the carboxyl group of an amino acid protected by a cyclic protecting group (n=1 or 2). Next, the target C-terminal-free non-natural amino acid can be prepared by conducting reduction reaction according to the method of Reeves et al. (Advanced Synthesis &amp; Catalysis, 2013, 355(1), 47-52) and then performing ring-opening reaction. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having a fluoroalkyl group introduced onto the amino acid side chain can be prepared according to the following scheme. The carboxyl group of a commercially available protected amino acid (n=1 or 2) can be reduced and converted to an aldehyde group according to a conventional method, and the aldehyde group can be converted to a difluoromethyl group by introducing a fluorine atom according to a conventional method. Next, a C-terminal-free non-natural amino acid can be prepared by deprotecting the C-terminal protecting group. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having a fluoroalkyl group introduced onto the amino acid side chain and a —CH 2 —P′ group introduced onto the amino acid nitrogen atom can be prepared according to the following scheme. The carboxyl group of an amino acid protected by a cyclic protecting group (n=1 or 2) can be reduced and converted to an aldehyde group according to a conventional method, and the aldehyde group can be converted to a difluoromethyl group by introducing a fluorine atom according to a conventional method. Next, a C-terminal-free non-natural amino acid can be prepared by ring-opening of the C-terminal cyclic protecting group. 
     
       
         
         
             
             
         
       
     
     C-terminal-free non-natural amino acids having a fluoroalkyl group introduced onto the amino acid side chain and a —CH 2 —P′ group introduced onto the amino acid nitrogen atom can also be prepared by the method shown below. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having an aryl or heteroaryl group (such groups are referred to as “Ar” in the scheme) introduced onto the amino acid side chain can be prepared according to the following scheme. An N-hydroxyphthalimide (NHPI) group can be introduced onto the side chain by allowing NHPI to act on the carboxyl group of a protected amino acid (n=1 or 2). A non-natural amino acid having an aryl or heteroaryl group introduced and possessing an aralkyl or heteroaralkyl group on the side chain can be prepared by allowing an aryl halide or heteroaryl halide to react according to the method of Huihui et al. (J. Am. Chem. Soc., 2016, 138(15), 5016-5019). Next, a C-terminal-free non-natural amino acid can be prepared by deprotecting the C-terminal protecting group. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having an aryl or heteroaryl group (such groups are referred to as “Ar” in the scheme) introduced onto the amino acid side chain and having a —CH 2 —P′ group introduced onto the amino acid nitrogen atom can be prepared according to the following scheme. An N-hydroxyphthalimide (NHPI) group can be introduced onto the side chain by allowing NHPI to act on the carboxyl group of an amino acid protected by a cyclic protecting group (n=1 or 2). A non-natural amino acid which has an aryl or heteroaryl group introduced, and has an aralkyl or heteroarylalkyl group on the side chain, and is protected by a cyclic protecting group, can be prepared by allowing an aryl halide or heteroaryl halide to react according to the method of Huihui et al. (J. Am. Chem. Soc., 2016, 138(15), 5016-5019). Next, the target C-terminal-free non-natural amino acid can be prepared by ring-opening reaction. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having an aryl or heteroaryl group (such groups are referred to as “Ar” in the scheme) introduced onto the amino acid side chain can be prepared according to the following scheme. A non-natural amino acid having an aryl or heteroaryl group introduced and possessing an aralkyl or heteroaralkyl group on the side chain can be prepared by introducing a protecting group onto a commercially available protected amino group (n=0 or 1) and then allowing an aryl halide or heteroaryl halide to react according to the method of He et al. (Org. Lett. 2014, 16(24), 6488-6491). Next, the target C-terminal-free non-natural amino acid can be prepared by deprotection reaction and protecting group introduction reaction. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having a halogen atom introduced onto the aralkyl group on the amino acid side chain can be prepared according to the following scheme. A boronic acid ester can be introduced onto the aralkyl group (n=1 to 3) which may have a substituent (R a ) on the amino acid side chain according to the method of Ishiyama et al. (J. Am. Chem. Soc. 2002, 124(3), 390-391). A halogen atom can be introduced onto the introduced boryl group using N-halosuccinimide according to the method of Lindner et al. (Chem. Eur. J., 2016, 22, 13218-13235). The target C-terminal-free non-natural amino acid can be prepared by appropriately introducing/removing a protecting group onto/from the obtained non-natural amino acid as necessary. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having a halogen atom introduced onto the aralkyl group of the amino acid side chain and a —CH 2 —P′ group introduced onto the amino acid nitrogen atom can be prepared according to the following scheme. A boronic acid ester can be introduced onto the aryl group of the amino acid having an aralkyl group (n=1 to 3) which may have a substituent (R a ) on the amino acid side chain according to the method of Ishiyama et al. (J. Am. Chem. Soc. 2002, 124(3), 390-391). A halogen atom can be introduced onto the introduced boryl group using N-halosuccinimide according to the method of Lindner et al. (Chem. Eur. J., 2016, 22, 13218-13235). The target C-terminal-free non-natural amino acid can be prepared by appropriately introducing/removing a protecting group onto/from the obtained non-natural amino acid as necessary. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Non-natural amino acids having an optionally substituted alkoxy or aralkoxy (R b O) group on the amino acid side chain can be prepared according to the following scheme. A cyclized compound can be obtained according to the method of Mitsunobu et al. (Synthesis, 1981, 1,1-28) after introducing a nosyl (Ns) group onto a commercially available serine derivative according to a conventional method. A serine ether compound can be obtained by ring-opening of the cyclized compound with a suitable alcohol (R b OH) in the presence of a Lewis acid such as BF 3 .OEt 2 . The target C-terminal-free non-natural amino acid can be prepared by appropriately introducing/removing a protecting group onto/from the obtained non-natural amino acid as necessary. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having an optionally substituted alkoxy or aralkoxy (R b O) group on the amino acid side chain can be prepared according to the following scheme. A serine ether compound can be obtained by ring-opening of a commercially available cyclic compound with a suitable alcohol (R b OH) in the presence of a Lewis acid such as BF 3 .OEt 2  according to a conventional method. The target C-terminal-free non-natural amino acid can be prepared by appropriately introducing/removing a protecting group onto/from the obtained non-natural amino acid as necessary. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having an optionally substituted alkoxy or aralkoxy (—OR b ) group on the amino acid side chain can be prepared according to the following scheme. A serine ether compound can be obtained by allowing an alkylating agent (R b —X) to act on a commercially available serine derivative (n=1 or 2) in the presence of a suitable base according to the method of Williamson et al. (Liebigs Ann. Chem. 1851, 77, 37-49). When R b  has a further convertible functional group, R b  can be converted to a target functional group by additional functional group conversion. Examples of such additional functional group conversion include multiple bond reduction reaction. Next, the target C-terminal-free non-natural amino acid can be prepared by deprotecting the obtained non-natural amino acid. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having an optionally substituted alkoxy or aralkoxy (—OR b ) group on the amino acid side chain and having a group introduced onto the amino acid nitrogen atom can be prepared according to the following scheme. An oxazolidinone compound having a cyclic protecting group introduced can be obtained by allowing an aldehyde to act on a commercially available serine derivative or a serine derivative prepared by the above-described method (n=1 or 2) according to the method of Freidinger et al. (J. Org. Chem., 1983, 48(1), 77-81). Next, the target C-terminal-free non-natural amino acid can be prepared by ring-opening reaction. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having a protected hydroxy group on the amino acid side chain can be prepared according to the following scheme. The target C-terminal-free non-natural amino acid can be prepared by appropriately introducing/removing a protecting group onto/from a commercially available serine derivative or a serine derivative prepared by the above-described method (n=1 or 2). 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having a protected hydroxy group on the amino acid side chain and a —CH 2 —P′ group introduced onto the amino acid nitrogen atom can be prepared according to the following scheme. An oxazolidinone compound having a cyclic protecting group introduced can be obtained by allowing an aldehyde to act on a commercially available serine derivative or a serine derivative prepared by the above-described method (n=1 or 2) according to the method of Freidinger et al. (J. Org. Chem., 1983, 48(1), 77-81). Next, the target C-terminal-free non-natural amino acid can be prepared by ring-opening reaction and protecting group introduction reaction. 
     
       
         
         
             
             
         
       
     
     Cyclic non-natural amino acids having a substituent (R c ) introduced onto the hydroxyl group of the cyclic amino acid can be prepared according to the following scheme. The hydroxy group of a commercially available cyclic amino acid can be converted to the target —OR c  group by appropriately introducing a functional group. As a reaction of converting the functional group, an ether bond can be produced by allowing an alkylating agent (R c —X) to react in the presence of a suitable base according to the method of Williamson et al. (Liebigs Ann. Chem. 1851, 77, 37-49). When R c  has a further convertible functional group, R c  can be converted to a target functional group by additional functional group conversion. Next, the target C-terminal-free non-natural amino acid can be prepared by deprotection reaction. 
     
       
         
         
             
             
         
       
     
     Cyclic non-natural amino acids having a protecting group (PG 3 ) introduced onto the hydroxyl group of the cyclic amino acid can be prepared according to the following scheme. The target C-terminal-free non-natural amino acid can be prepared by appropriately introducing/removing a protecting group onto/from a commercially available cyclic amino acid. 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids having a boronic acid introduced onto the amino acid side chain can be prepared according to the following scheme. A non-natural amino acid having a boronic acid ester introduced can be obtained by allowing an aldehyde to act on a commercially available glycine derivative according to the method of Lee et al. (Bioorg. Med. Chem. Lett., 2009, 19(17), 4887-5274). Next, the target C-terminal-free non-natural amino acid can be prepared by appropriately introducing or removing a protecting group. 
     
       
         
         
             
             
         
       
     
     (Synthesis 1 of Fmoc Non-Natural Amino Acids Having a Carboxyl Group on the Side Chain) 
     Fmoc non-natural amino acids having a carboxyl group on the side chain can be prepared according to the following scheme. The main chain carboxyl group of a starting material which is available from a commercial supplier and has a side chain carboxyl group protected by PG 3  (n=1 or 2) can be converted to an amido group by condensing it with an amine (R″R′″NH) in the presence of a condensing agent such as DIC. Next, the target Fmoc non-natural amino acid having a carboxyl group on the side chain can be prepared by deprotecting PG 3 . 
     
       
         
         
             
             
         
       
     
     (Synthesis 2 of Fmoc Non-Natural Amino Acids Having a Carboxyl Group on the Side Chain) 
     Fmoc non-natural amino acids having a carboxyl group on the side chain and a —CH 2 —P′ group introduced onto the amino acid nitrogen atom can be prepared according to the following scheme. The main chain carboxyl group of a starting material which is available from a commercial supplier and has a side chain carboxyl group protected by PG 3  (n=1 or 2) can be converted to an amido group by condensing it with an amine (R″R′″NH) in the presence of a condensing agent such as DIC. Next, the target Fmoc non-natural amino acid having a carboxyl group on the side chain can be prepared by deprotecting PG 3 . 
     
       
         
         
             
             
         
       
     
     Non-natural amino acids (n=1 or 2) containing a thioether group on the side chain can be produced according to the following scheme. An amino acid having a protected side chain thiol group was subjected to carboxylic acid amidation, and following deprotection of the thiol group, halogenated acetic acid having a protected carboxylic acid was allowed to react to form a thioether bond. Next, the amino acid having a thioether group on the side chain can be produced by deprotecting the side chain carboxylic acid. 
     
       
         
         
             
             
         
       
     
     Peptides containing a thioether group on the peptide main chain can be produced by using as a raw material the aforementioned amino acid having a thioether group on the side chain, but alternatively, they can also be produced by the method of Roberts et al. in which an N-terminal bromoacetamide is reacted with a cysteine side chain (Tetrahedron Letters, 1998, 39, 8357-8360), or the method of Robey et al. in which an N-terminal chloroacetamide is reacted with a cysteine side chain (Journal of Peptide Research, 2000, 56, 115-120). 
     The compounds of the present invention and salts thereof, and solvates thereof include all stereoisomers (such as enantiomers and diastereomers (including cis and trans geometric isomers)) of the target compounds obtained through the above-described reaction steps, and racemates and other mixtures of such isomers. For example, the compounds of the present invention may have one or more asymmetric points, and the present invention encompasses racemic mixtures, diastereomeric mixtures, and enantiomers of such compounds. 
     When the compounds according to the present invention are obtained as free forms, they can be converted to salts that may be formed by such compounds, or hydrates or solvates thereof, according to conventional methods. 
     When the compounds according to the present invention are obtained as salts, hydrates, or solvates of such compounds, they can be converted to free forms of such compounds according to conventional methods. 
     &lt;Pharmaceutical Compositions&gt; 
     The present invention provides pharmaceutical compositions containing the cyclic peptide compounds of the present invention. 
     The pharmaceutical compositions of the present invention can be formulated by introducing a pharmaceutically acceptable carrier, in addition to the cyclic peptide compound of the present invention, a salt of the cyclic peptide compound, or a solvate thereof by conventional methods. Commonly used excipients, binders, lubricants, colorants, correctives, and as necessary, stabilizers, emulsifiers, absorption promoters, surfactants, pH adjusters, preservatives, antioxidants, and the like can be used for formulation, and they are blended with ingredients generally used as raw materials of pharmaceutical formulations, and formulated by conventional methods. 
     For example, oral formulations are prepared by adding the cyclic peptide compound of the present invention or a salt thereof, and an excipient, and as necessary, a binder, a disintegrant, a lubricant, a colorant, a corrective, and the like, and then formulating them into powder, fine granules, granules, tablets, coated tablets, capsules, and the like by a conventional method. 
     Examples of these ingredients include animal and vegetable oils such as soybean oil, beef tallow, and synthetic glyceride; hydrocarbons such as liquid paraffin, squalane, and solid paraffin; ester oils such as octyldodecyl myristate and isopropyl myristate; higher alcohols such as cetostearyl alcohol and behenyl alcohol; silicone resin; silicone oil; surfactants such as polyoxyethylene fatty acid ester, sorbitan fatty acid ester, glycerol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, and polyoxyethylene-polyoxypropylene block copolymer; water-soluble polymers such as hydroxyethylcellulose, polyacrylic acid, carboxyvinyl polymer, polyethylene glycol, polyvinylpyrrolidone, and methylcellulose; lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as glycerol, propylene glycol, dipropylene glycol, and sorbitol; sugars such as glucose and sucrose; inorganic powders such as silicic anhydride, magnesium aluminum silicate, and aluminum silicate; and purified water. 
     Examples of the excipients include lactose, corn starch, white soft sugar, glucose, mannitol, sorbitol, microcrystalline cellulose, and silicon dioxide. 
     Examples of the binders include polyvinyl alcohol, polyvinyl ether, methylcellulose, ethylcellulose, acacia, tragacanth, gelatin, shellac, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinylpyrrolidone, polypropylene glycol-polyoxyethylene block polymer, and meglumine. 
     Examples of the disintegrants include starch, agar, gelatin powder, microcrystalline cellulose, calcium carbonate, sodium bicarbonate, calcium citrate, dextrin, pectin, and carboxymethylcellulose calcium. 
     Examples of the lubricants include magnesium stearate, talc, polyethylene glycol, silica, and hydrogenated vegetable oil. 
     For colorants, those approved as additives to pharmaceuticals are used. For correctives, cocoa powder, peppermint camphor, empasm, mentha oil, borneol, powdered cinnamon bark, and the like are used. 
     Obviously, these tablets and granules may be sugar-coated or otherwise coated appropriately as necessary. When liquid formulations such as syrups and injectable formulations are prepared, they are formulated by adding pH adjusters, solubilizers, tonicity adjusting agents, and the like, and as necessary, solubilizing agents, stabilizers, and the like to the compounds according to the present invention or pharmacologically acceptable salts thereof using conventional methods. 
     For example, the pharmaceutical compositions can be parenterally used in the form of injectable sterile solutions or suspensions with water or other pharmaceutically acceptable liquids. For example, they would be formulated by appropriately combining with pharmacologically acceptable carriers or media, specifically, sterile water, saline, vegetable oils, emulsifiers, suspending agents, surfactants, stabilizers, flavoring agents, excipients, vehicles, preservatives, or binders, and blending in unit dosage forms required in generally approved formulation. Specifically, carriers may include light anhydrous silicic acid, lactose, microcrystalline cellulose, mannitol, starch, carmellose calcium, carmellose sodium, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinyl acetal diethylaminoacetate, polyvinylpyrrolidone, gelatin, medium chain fatty acid triglyceride, polyoxyethylene hydrogenated castor oil 60, white soft sugar, carboxymethylcellulose, corn starch, and inorganic salts. The amount of the active ingredient in such a formulation is designed to provide a suitable dose within an indicated range. 
     Sterile compositions for injection can be formulated in a conventional formulation manner using a vehicle such as distilled water for injection. 
     Aqueous solutions for injection include, for example, isotonic solutions containing saline, glucose, and other adjuvants, such as D-sorbitol, D-mannose, D-mannitol, and sodium chloride, and may be used in combination with appropriate solubilizers, for example, alcohols, specifically, ethanol, polyalcohols, e.g., propylene glycol or polyethylene glycol, and nonionic surfactants, e.g., polysorbate 80 (registered trademark) or HCO-50. 
     Oily liquids include sesame oil and soybean oil, and may be used in combination with benzyl benzoate and benzyl alcohol as solubilizers. They may also be blended with buffering agents such as phosphate buffer and sodium acetate buffer; analgesics such as procaine hydrochloride; stabilizers such as benzyl alcohol and phenol; and antioxidants. Prepared injections are usually packed in suitable ampoules. 
     The administration method is preferably oral administration, but is not limited thereto. Specific examples of parenteral administration include dosage forms of injection, nasal administration, pulmonary administration, and transdermal administration. Examples of injection dosage forms include systemic or local administration by intravenous injection, intramuscular injection, intraperitoneal injection, subcutaneous injection, etc. 
     The administration method can also be selected according to the age and symptom of the patient. The dosage of the pharmaceutical composition containing the peptide compound prepared by the method of the present invention can be selected, for example, in the range of 0.0001 mg to 1000 mg per kg body weight per dose. Alternatively, the dosage can be selected, for example, in the range of 0.001 to 100000 mg/body per patient; however, it is not necessarily limited to such values. The dosage and the administration method vary according to the body weight, the age, the symptom, and the like of the patient, but can be appropriately selected by those skilled in the art. 
     In some embodiments, the compounds of the present invention can be used for inhibiting binding between Kras and SOS. 
     In some embodiments, the pharmaceutical compositions of the present invention can be used for treating or preventing cancer in a subject. Specific examples of the cancer include pancreatic cancer. 
     The term “subject” herein includes mammals, and mammals are preferably humans. 
     All prior art documents cited in the present specification are incorporated herein by reference. 
    
    
     EXAMPLE 
     The content of the present invention will be further described with reference to Examples and Reference Examples below, but it is not to be construed as being limited thereto. All starting materials and reagents were obtained from commercial suppliers or synthesized by known methods. The LC/MS analysis conditions are described in Table 1. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
             
            
               
                 Analysis 
                   
                 Column 
                   
               
               
                 condition 
                 Device 
                 (I.D. × Length)(mm) 
                 Mobile phase 
               
               
                   
               
               
                 SQDAA05 
                 Acquity UPLC/SQD 
                 Ascentis Express C18 
                 A) 10 mM AcONH 4 , water 
               
               
                   
                 or 
                 (2.1 × 50) 
                 B) methanol 
               
               
                   
                 Acquity UPLC/SQD2 
               
               
                 SQDFA05 
                 Acquity UPLC/SQD 
                 Ascentis Express C18 
                 A) 0.1% FA, water 
               
               
                   
                 or 
                 (2.1 × 50) 
                 B) 0.1% FA, acetonitrile 
               
               
                   
                 Acquity UPLC/SQD2 
               
               
                 SQDAA50 
                 Acquity UPLC/SQD 
                 Ascentis Express C18 
                 A) 10 mM AcONH 4 , water 
               
               
                   
                 or 
                 (2.1 × 50) 
                 B) methanol 
               
               
                   
                 Acquity UPLC/SQD2 
               
               
                 SQDFA50 
                 Acquity UPLC/SQD 
                 Ascentis Express C18 
                 A) 0.1% FA, water 
               
               
                   
                 or 
                 (2.1 × 50) 
                 B) 0.1% FA, acetonitrile 
               
               
                   
                 Acquity UPLC/SQD2 
               
               
                 SQDFA05long 
                 Acquity UPLC/SQD2 
                 Ascentis Express C18 
                 A) 0.1% FA, water 
               
               
                   
                   
                 (2.1 × 50) 
                 B) 0.1% FA, acetonitrile 
               
               
                 SQDFA3080 
                 Acquity UPLC/SQD2 
                 Ascentis Express C18 
                 A) 0.1% FA, water 
               
               
                   
                   
                 (2.1 × 50) 
                 B) 0.1% FA, acetonitrile 
               
               
                 SQDFA30long50deg 
                 Acquity UPLC/SQD2 
                 Ascentis Express C18 
                 A) 0.1% FA, water 
               
               
                   
                   
                 (2.1 × 50) 
                 B) 0.1% FA, acetonitrile 
               
               
                 SMDmethod_01 
                 Shimadzu 
                 Kinetex EVO C18 
                 A) 6.5 mM NH 4 HCO 3  water 
               
               
                   
                 LCMS-2020 
                 (2.1 × 50) 
                 (pH = 10) 
               
               
                   
                   
                   
                 B) acetonitrile 
               
               
                 SMDmethod 02 
                 Shimadzu 
                 Shim-Pack XR-ODS 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2020 
                 (3.0 × 50) 
                 B) 0.05% TFA, acetonitrile 
               
               
                 SMDmethod_03 
                 Nexera/2020 
                 Ascentis Express C18 
                 A) 0.1% FA, water 
               
               
                   
                   
                 (2.1 × 50) 
                 B) 0.1% FA, acetonitrile 
               
               
                 SMDmethod_04 
                 Nexera/2020 
                 Ascentis Express C18 
                 A) 0.1% FA, water 
               
               
                   
                   
                 (2.1 × 50) 
                 B) 0.1% FA, acetonitrile 
               
               
                 SMDmethod_05 
                 Shimadzu 
                 Shim-Pack XR-ODS 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2020 
                 (3.0x50) 
                 B) 0.05% TFA, acetonitrile 
               
               
                 SMDmethod_06 
                 Nexera/2020 
                 Speed Core C18 
                 A) 0.1% FA, water 
               
               
                   
                   
                 (2.1 × 50) 
                 B) 0.1% FA, acetonitrile 
               
               
                 SMDmethod_07 
                 Shimadzu 
                 Shim-Pack XR-ODS 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2020 
                 (3.0 × 50) 
                 B) 0.05% TFA, acetonitrile 
               
               
                 SMDmethod 08 
                 Shimadzu 
                 Shim-Pack XR-ODS 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2010EV 
                 (3.0 × 50) 
                 B) 0.05% TFA, acetonitrile 
               
               
                 SMDmethod 09 
                 Shimadzu 
                 Shim-Pack XR-ODS 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2010EV 
                 (3.0 × 50) 
                 B) 0.05% TFA, acetonitrile 
               
               
                 SMDmethod 10 
                 Shimadzu 
                 Gemini-NX 3u C18 
                 A) 6.5 mM NH 4 HCO 3  water 
               
               
                   
                 LCMS-2020 
                 110A 
                 (pH = 10) 
               
               
                   
                   
                 (3.0 × 50) 
                 B) acetonitrile 
               
               
                 SMDmethod_11 
                 Shimadzu 
                 Phenomenex kinetex 
                 A) 0.1% FA, water 
               
               
                   
                 LCMS-2020 
                 C18 
                 B) 0.1% FA, acetonitrile 
               
               
                   
                   
                 (3.0 × 50) 
               
               
                 SMDmethod_12 
                 Shimadzu 
                 Shim-Pack XR-ODS 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2020 
                 (3.0 × 50) 
                 B) 0.05% TFA, acetonitrile 
               
               
                 SMDmethod_13 
                 Shimadzu 
                 Shim-Pack XR-ODS 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2020 
                 (3.0 × 50) 
                 B) 0.05% TFA, acetonitrile 
               
               
                 SMDmethod_14 
                 Shimadzu 
                 Shim-Pack XR-ODS 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2020 
                 (3.0 × 50) 
                 B) 0.05% TFA, acetonitrile 
               
               
                 SMDmethod_15 
                 Shimadzu 
                 Shim-Pack XR-ODS 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2020 
                 (3.0 × 50) 
                 B) 0.05% TFA, acetonitrile 
               
               
                 SMDmethod_16 
                 Shimadzu 
                 Accucore C18 
                 A) 0.1% FA, water 
               
               
                   
                 LCMS-2020 
                 (2.1 × 50) 
                 B) 0.1% FA, acetonitrile 
               
               
                 SMDmethod_17 
                 Shimadzu 
                 Ascentis Express 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2020 
                 C18 
                 B) 0.05% TFA, acetonitrile 
               
               
                   
                   
                 (3.0 × 50) 
               
               
                 SMDmethod_18 
                 Shimadzu 
                 CORTECS C18 
                 A) 0.1% FA, water 
               
               
                   
                 LCMS-2020 
                 (2.1 × 50) 
                 B) 0.1% FA, acetonitrile 
               
               
                 SMDmethod_19 
                 Shimadzu 
                 ACQUITY BEH C18 
                 A) 0.15% FA, water 
               
               
                   
                 LCMS-2020 
                 (2.1 × 50) 
                 B) 0.15% FA, acetonitrile 
               
               
                 SMDmethod_20 
                 Shimadzu 
                 Ascentis Express 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2020 
                 C18 
                 B) 0.05% TFA, acetonitrile 
               
               
                   
                   
                 (3.0 × 50) 
               
               
                 SMDmethod_21 
                 Shimadzu 
                 Shim-Pack XR-ODS 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2010EV 
                 (3.0 × 50) 
                 B) 0.05% TFA, acetonitrile 
               
               
                 SMDmethod_22 
                 Shimadzu 
                 ACQUITY BEH C18 
                 A) 0.1% FA, water 
               
               
                   
                 LCMS-2020 
                 (2.1 × 50) 
                 B) 0.05% FA, acetonitrile 
               
               
                 SMDmethod_23 
                 Shimadzu 
                 Shim-Pack XR-ODS 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2020 
                 (3.0 × 50) 
                 B) 0.05% TFA, acetonitrile 
               
               
                 SSC-AA-20 
                 Nexera UC/2020 
                 Ascentis Express 
                 A) 10 mM AcONH 4 , water 
               
               
                   
                   
                 C18 
                 B) methanol/1M AcONH 4 , 
               
               
                   
                   
                 (2.1 × 50) 
                 water = 100/1 
               
               
                 SSC-AF-00 
                 Nexera UC/2020 
                 Ascentis Express 
                 A) 10 mM NH 4 HCO 2   
               
               
                   
                   
                 C18 
                 water 
               
               
                   
                   
                 (2.1 × 50) 
                 B) methanol 
               
               
                 SSC-FA-03 
                 Nexera UC/2020 
                 XSelect CSH C18 
                 A) 0.1% FA, water 
               
               
                   
                   
                 (2.1 × 50) 
                 B) 0.1% FA, acetonitrile 
               
               
                 SSC-TFA-07 
                 Nexera/2020 
                 Ascentis Express 
                 A) 0.05% TFA, water 
               
               
                   
                   
                 C18 
                 B) 0.05% TFA, acetonitrile 
               
               
                   
                   
                 (2.1 × 50) 
               
               
                 SSC-A-AF-01 
                 Nexera UC/2020 
                 Ascentis Express 
                 A) 10 mM NH 4 HCO 2   
               
               
                   
                   
                 C18 
                 water 
               
               
                   
                   
                 (2.1 × 50) 
                 B) methanol 
               
               
                 SSC-A-AF-02 
                 Nexera UC/2020 
                 Ascentis Express 
                 A) 10 mM NH 4 HCO 2   
               
               
                   
                   
                 C18 
                 water 
               
               
                   
                   
                 (2.1 × 50) 
                 B) methanol 
               
               
                 SSC-A-FA-01 
                 Nexera UC/2020 
                 XSelect CSH C18 
                 A) 0.1% FA, water 
               
               
                   
                   
                 (2.1 × 50) 
                 B) 0.1% FA, acetonitrile 
               
               
                 SSC-A-FA-02 
                 Nexera UC/2020 
                 XSelect CSH C18 
                 A) 0.1% FA, water 
               
               
                   
                   
                 (2.1 × 50) 
                 B) 0.1% FA, acetonitrile 
               
               
                 SQDFA05long 
                 Acquity UPLC/SQD2 
                 Ascentis Express 
                 A) 0.1% FA, water 
               
               
                   
                   
                 C18 
                 B) 0.1% FA, acetonitrile 
               
               
                   
                   
                 (2.1 × 50) 
               
               
                 SMDmethod_30 
                 Shimadzu 
                 Halo C18 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2020 
                 (3.0 × 30) 
                 B) 0.05% TFA, acetonitrile 
               
               
                 SMDmethod_31 
                 Shimadzu 
                 Ascentis Express 
                 A) 0.05% TFA, water 
               
               
                   
                 LCMS-2020 
                 C18 
                 B) 0.05% TFA, acetonitrile 
               
               
                   
                   
                 (3.0 × 50) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                 Flow 
                 Column 
                   
                   
               
               
                 Analysis 
                   
                 rate 
                 temperature 
               
               
                 condition 
                 Gradient (A/B) 
                 (mL/min) 
                 (° C.) 
                 Wavelength 
                 Remarks 
               
               
                   
               
               
                 SQDAA05 
                 95/5 (initial) =&gt; 
                 1.0 
                 35 
                 210-400 nm 
               
               
                   
                 0/100 (1.0 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.4 min) 
               
               
                 SQDFA05 
                 95/5 (initial) =&gt; 
                 1.0 
                 35 
                 210-400 nm 
               
               
                   
                 0/100 (1.0 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.4 min) 
               
               
                 SQDAA50 
                 50/50 (initial) =&gt; 
                 1.0 
                 35 
                 210-400 nm 
               
               
                   
                 0/100 (0.7 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.7 min) 
               
               
                 SQDFA50 
                 50/50 (initial) =&gt; 
                 1.0 
                 35 
                 210-400 nm 
               
               
                   
                 0/100 (0.7 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.7 min) 
               
               
                 SQDFA05long 
                 95/5 (initial) =&gt; 
                 1.0 
                 35 
                 210-400 nm 
               
               
                   
                 0/100 (4.5 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.5 min) 
               
               
                 SQDFA3080 
                 70/30 (initial) =&gt; 
                 1.0 (initial- 
                 35 
                 210-400 nm 
               
               
                   
                 20/80 (4.5 min) =&gt; 
                 4.51 min) 
                   
                 PDA total 
               
               
                   
                 0/100 (0.01 min) =&gt; 
                 0.1 (4.51- 
               
               
                   
                 0/100 (0.49 min) 
                 5.00 min) 
               
               
                 SQDFA30long50deg 
                 70/30 (initial) =&gt; 
                 0.5 
                 50 
                 210-400 nm 
               
               
                   
                 0/100 (8.0 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (2.0 min) 
               
               
                 SMDmethod_01 
                 90/10 (initial) =&gt; 
                 1.0 
                 35 
                 190-400 nm 
               
               
                   
                 50/50 (3.8 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 5/95 (0.4 min) =&gt; 
               
               
                   
                 5/95 (0.4 min) 
               
               
                 SMDmethod 02 
                 60/40 (initial) =&gt; 
                 1.2 
                 40 
                 190-400 nm 
               
               
                   
                 5/95 (3.0 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 5/95 (0.7 min) 
               
               
                 SMDmethod_03 
                 95/5 (initial) =&gt; 
                 1.0 
                 35 
                 210-400 nm 
               
               
                   
                 0/100 (4.5 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.5 min) 
               
               
                 SMDmethod_04 
                 95/5 (initial) =&gt; 
                 1.0 
                 35 
                 210-400 nm 
               
               
                   
                 0/100 (1.5 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.5 min) 
               
               
                 SMDmethod_05 
                 95/5 (initial) =&gt; 
                 1.2 
                 40 
                 190-400 nm 
               
               
                   
                 5/95 (2.0 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 5/95 (0.7 min) 
               
               
                 SMDmethod_06 
                 95/5 (initial) =&gt; 
                 1.0 
                 35 
                 210-400 nm 
               
               
                   
                 0/100(1.5 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100(0.5 min) 
               
               
                 SMDmethod_07 
                 50/50 (initial) =&gt; 
                 1.2 
                 40 
                 190-400 nm 
               
               
                   
                 5/95 (3.8 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 5/95 (0.8 min) 
               
               
                 SMDmethod 08 
                 50/50 (initial) =&gt; 
                 1.2 
                 40 
                 190-400 nm 
               
               
                   
                 5/95 (2.0 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 5/95 (0.7 min) 
               
               
                 SMDmethod 09 
                 50/50 (initial) =&gt; 
                 1.2 
                 40 
                 190-400 nm 
               
               
                   
                 5/95 (4.1 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 5/95 (0.9 min) 
               
               
                 SMDmethod 10 
                 70/30 (initial) =&gt; 
                 1.2 
                 45 
                 190-400 nm 
               
               
                   
                 20/80 (4.0 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 5/95 (0.5 min) =&gt; 
               
               
                   
                 5/95 (0.5 min) 
               
               
                 SMDmethod_11 
                 90/10 (initial) =&gt; 
                 1.5 
                 40 
                 190-400 nm 
               
               
                   
                 5/95 (2.0 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 5/95 (0.7 min) 
               
               
                 SMDmethod_12 
                 95/5 (initial) =&gt; 
                 1.2 
                 40 
                 190-400 nm 
               
               
                   
                 5/95 (3.0 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 5/95 (0.7 min) 
               
               
                 SMDmethod_13 
                 50/50 (initial) =&gt; 
                 1.2 
                 40 
                 190-400 nm 
               
               
                   
                 5/95 (2.0 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 5/95 (0.7 min) 
               
               
                 SMDmethod_14 
                 70/30 (initial) =&gt; 
                 1.2 
                 40 
                 190-400nm 
               
               
                   
                 20/80 (3.8 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.3 min) =&gt; 
               
               
                   
                 0/100 (0.5 min) 
               
               
                 SMDmethod_15 
                 95/5 (initial) =&gt; 
                 1.2 
                 40 
                 190-400 nm 
               
               
                   
                 0/100 (1.1 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.6 min) 
               
               
                 SMDmethod_16 
                 90/10 (initial) =&gt; 
                 1.0 
                 40 
                 190-400 nm 
               
               
                   
                 0/100 (1.1 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.5 min) 
               
               
                 SMDmethod_17 
                 95/5 (initial) =&gt; 
                 1.0 
                 40 
                 190-400 nm 
               
               
                   
                 5/95 (2.7 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 5/95 (1.0 min) 
               
               
                 SMDmethod_18 
                 95/5 (initial) =&gt; 
                 1.0 
                 40 
                 190-400 nm 
               
               
                   
                 0/100 (1.0 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.5 min) 
               
               
                 SMDmethod_19 
                 90/10 (initial) =&gt; 
                 0.7 
                 45 
                 190-600 nm 
               
               
                   
                 30/70 (3.6 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 30/70 (1.0 min) 
               
               
                 SMDmethod_20 
                 95/5 (initial) =&gt; 
                 1.0 
                 40 
                 190-400 nm 
               
               
                   
                 5/95 (1.1 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 5/95 (0.5 min) 
               
               
                 SMDmethod_21 
                 95/5 (initial) =&gt; 
                 1.2 
                 40 
                 190-400 nm 
               
               
                   
                 5/95 (2.0 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 5/95 (0.7 min) 
               
               
                 SMDmethod_22 
                 95/6 (initial) =&gt; 
                 0.7 
                 45 
                 190-800 nm 
               
               
                   
                 20/80 (4 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 20/80 (1.2 min) 
               
               
                 SMDmethod_23 
                 95/5 (initial) =&gt; 
                 1.0 
                 40 
                 190-400 nm 
               
               
                   
                 0/100 (1.2 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (1 min) 
               
               
                 SSC-AA-20 
                 95/5 (initial) =&gt; 
                 1.0 
                 35 
                 210-400 nm 
               
               
                   
                 0/100 (1.75 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (1.25 min) 
               
               
                 SSC-AF-00 
                 95/5 (initial) =&gt; 
                 1.0 
                 35 
                 210-400 nm 
               
               
                   
                 0/100 (1.75 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (1.25 min) 
               
               
                 SSC-FA-03 
                 95/5 (initial) =&gt; 
                 1.0 
                 35 
                 210-400 nm 
               
               
                   
                 0/100 (1.75 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (1.25 min) 
               
               
                 SSC-TFA-07 
                 95/5 (initial) =&gt; 
                 1.0 
                 35 
                 210-400 nm 
               
               
                   
                 0/100 (1.5 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.5 min) 
               
               
                 SSC-A-AF-01 
                 70/30 (initial) =&gt; 
                 0.5 
                 50 
                 210-400 nm 
                 Loop 
               
               
                   
                 0/100 (8.75 min) =&gt; 
                   
                   
                 PDA total 
                 injection 
               
               
                   
                 0/100 (1.25 min) 
               
               
                 SSC-A-AF-02 
                 70/30 (initial) =&gt; 
                 0.5 
                 50 
                 210-400 nm 
                 Total 
               
               
                   
                 0/100 (8.75 min) =&gt; 
                   
                   
                 PDA total 
                 volume 
               
               
                   
                 0/100 (1.25 min) 
                   
                   
                   
                 injection 
               
               
                 SSC-A-FA-01 
                 70/30 (initial) =&gt; 
                 0.5 
                 50 
                 210-400 nm 
                 Loop 
               
               
                   
                 10/90 (7.5 min) =&gt; 
                   
                   
                 PDA total 
                 injection 
               
               
                   
                 0/100 (0.01 min) =&gt; 
               
               
                   
                 0/100 (2.49 min) 
               
               
                 SSC-A-FA-02 
                 70/30 (initial) =&gt; 
                 0.5 
                 50 
                 210-400 nm 
                 Total 
               
               
                   
                 10/90 (7.5 min) =&gt; 
                   
                   
                 PDA total 
                 volume 
               
               
                   
                 0/100 (0.01 min) =&gt; 
                   
                   
                   
                 injection 
               
               
                   
                 0/100 (2.49 min) 
               
               
                 SQDFA05long 
                 95/5 (initial) =&gt; 
                 1.0 
                 35 
                 210-400 nm 
               
               
                   
                 0/100 (4.5 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0. 5 min) 
               
               
                 SMDmethod_30 
                 95/5 (initial) =&gt; 
                 1.2 
                 45 
                 190-400 nm 
               
               
                   
                 0/100 (0.7 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.4 min) 
               
               
                 SMDmethod_31 
                 95/5 (initial) =&gt; 
                 1.5 
                 40 
                 190-400 nm 
               
               
                   
                 0/100 (2.0 min) =&gt; 
                   
                   
                 PDA total 
               
               
                   
                 0/100 (0.7 min) 
               
               
                   
               
            
           
         
       
     
     Example 1 
     Solid-Phase Synthesis of Peptide Compounds 
     Peptides were elongated by the following basic route (also called the basic peptide synthesis method) according to the peptide synthesis method by Fmoc methods described in WO 2013/100132 or WO 2018/225864, specifically, by the following five steps: 
     1) elongation reaction of the peptide by the Fmoc method from the N-terminal amino acid of Asp side chain carboxylic acid or peptide main chain carboxylic acid loaded onto 2-chlorotrityl resin; 
     1 2) cleavage of the peptide from the 2-chlorotrityl resin; 
     1 3) amide cyclization by condensation between the Asp side chain carboxylic acid or peptide main chain carboxylic acid released from the 2-chlorotrityl resin by the cleavage and the amino group of the peptide chain N-terminus (triangle unit); 
     1 4) deprotection of the protecting group of a side chain functional group contained in the peptide chain, as necessary; and 
     1 5) purification of the compound by preparative HPLC. In the present Examples, unless otherwise stated, peptide compounds were synthesized based on this basic route. 
     
       
         
         
             
             
         
       
     
     1-1. Fmoc Amino Acids Used in Peptide Synthesis by a Peptide Synthesizer 
     Fmoc amino acids described in Tables 2 to 5 were used in peptide syntheses described herein using a peptide synthesizer. 
     Fmoc amino acids described in Table 2 were synthesized according to the methods described in WO 2013/100132 or WO 2018/225864. 
     Fmoc amino acids described in Table 3 were purchased from commercial suppliers or synthesized according to the methods described in WO 2018/225864. 
     Fmoc amino acids described in Table 4 were purchased from commercial suppliers. 
     Fmoc amino acids described in Table 5 were synthesized according to the schemes provided below. 
     
       
         
           
               
               
               
             
               
                 TABLE 2 
               
               
                   
               
               
                 Abbreviation 
                 Structural formula 
                 Name 
               
               
                   
               
             
            
               
                 Fmoc—MeAla(4-Thz)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxy carbonyl(methyl)amino]-3- (1,3-thiazol-4-yl)propanoic acid 
               
               
                 Fmoc—MePhe(3-Cl)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3-chlorophenyl)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]propanoic acid 
               
               
                 Fmoc—nPrGly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[9H-fluoren-9-yl methoxycarbonyl (propyl)amino]acetic acid 
               
               
                 Fmoc-Hyp(Et)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-ethoxy-1-(9H-fluoren-9-yl methoxycarbonyl)pyrrolidin-2- carboxylic acid 
               
               
                 Fmoc—(EtOEt)NGly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[2-ethoxyethyl(9H-fluoren-9-yl methoxycarbonyl)amino]acetic acid 
               
               
                 Fmoc-cisPro(pip-4-F2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-4-(4,4-difluoropiperidin-1-yl)- 1-(9H-fluoren-9-yl methoxycarbonyl) pyrrolidin-2-carboxylic acid 
               
               
                 Fmoc—Hnl(7-F2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxy carbonylamino)-7,7-difluoro heptanoic acid 
               
               
                 Fmoc—iPenGly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[9H-fluoren-9-yl methoxycarbonyl (3-methyl butyl)amino]acetic acid 
               
               
                 Fmoc—MeAbu(pip-3-F2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-4-(3,3-difluoropiperidin-1-yl)-2- [9H-fluoren-9-yl methoxycarbonyl (methyl)amino]butanoic acid 
               
               
                 Fmoc—MeGln(Me)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl (methyl)amino]-5- (methyl amino)-5-oxopentanoic acid 
               
               
                 Fmoc—MeGln(Me2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-5-(dimethyl amino)-2-[9H- fluoren-9-yl methoxycarbonyl(methyl) amino]-5-oxopentanoic acid 
               
               
                 Fmoc—MeHnl(7-F2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxy carbonyl(methyl)amino]-7,7-difluoro heptanoic acid 
               
               
                 Fmoc—MeHph—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxy carbonyl(methyl)amino]-4-phenyl butanoic acid 
               
               
                 Fmoc—MePhe(4-Cl)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(4-chlorophenyl)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl) amino]propanoic acid 
               
               
                 Fmoc—MeSer(THP)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxy carbonyl(methyl)amino]-3-(oxan-2- yloxy)propanoic acid 
               
               
                 Fmoc—MeSer(3-F-5-Me-Pyr)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxy carbonyl(methyl)amino]-3-[(5-fluoro pyridin-3-yl)methoxy]propanoic acid 
               
               
                 Fmoc—MeSer(iPen)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxy carbonyl(methyl)amino]-3-(3-methyl butoxy)propanoic acid 
               
               
                 Fmoc—MeSer(nPr)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxy carbonyl(methyl)amino]-3-propoxy propanoic acid 
               
               
                 Fmoc—MeSer(NtBu-Aca)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-[2-(tert-butyl amino)-2-oxo ethoxy]-2-[9H-fluoren-9-yl methoxy carbonyl(methyl)amino]propanoic acid 
               
               
                 Fmoc—MeSer(Ph-2-Cl)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(2-chlorophenoxy)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]propanoic acid 
               
               
                 Fmoc—MeSer(tBuOTHP)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxy carbonyl(methyl)amino]-3-[2-methyl- 2-(oxan-2-yloxy)propoxy]propanoic acid 
               
               
                 Fmoc—nBuGly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[butyl(9H-fluoren-9-yl methoxy carbonyl)amino]acetic acid 
               
               
                 Fmoc—Pro(4-pip-4-F2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-(4,4-difluoropiperidin-1- yl)-1-(9H-fluoren-9-yl methoxy carbonyl)pyrrolidin-2-carboxylic acid 
               
               
                 Fmoc-Ser(3-F-5-Me-Pyr)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxy carbonyl amino)-3-[(5-fluoropyridin- 3-yl)methoxy]propanoic acid 
               
               
                 Fmoc-Ser(iPen)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxy carbonyl amino)-3-(3-methylbutoxy) propanoic acid 
               
               
                 Fmoc-Ser(nPr)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxy carbonyl amino)-3-propoxypropanoic acid 
               
               
                 Fmoc-Ser(NtBu-Aca)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-[2-(tert-butyl am ino)-2-oxo ethoxy]-2-(9H-fluoren-9-yl methoxy carbonyl amino)propanoic acid 
               
               
                 Fmoc-Ser(tBuOTHP)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxy carbonyl amino)-3-[2-methyl-2-(oxan- 2-yloxy)propoxy]propanoic acid 
               
               
                 Fmoc-Thr(THP)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,3R)-2-(9H-fluoren-9-yl methoxy carbonyl amino)-3-(oxan-2-yloxy) butanoic acid 
               
               
                 Fmoc-Ser(THP)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxy carbonyl amino)-3-(oxan-2-yloxy) propanoic acid 
               
               
                 Fmoc-Tyr(3-F,tBu)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxy carbonyl amino)-3-[3-fluoro-4-[(2- methyl propan-2-yl)oxy]phenyl] propanoic acid 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 3 
               
               
                   
               
               
                 Abbreviation 
                 Structural formula 
                 Name 
               
               
                   
               
             
            
               
                 Fmoc—Hph(3-Cl)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-4-(3-chlorophenyl)-2-(9H- fluoren-9-yl methoxycarbonyl amino)butanoic acid 
               
               
                   
               
               
                 Fmoc—Hph(4-Cl)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-4-(4-chlorophenyl)-2-(9H- fluoren-9-yl methoxycarbonyl amino)butanoic acid 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                 TABLE 4 
               
               
                   
               
               
                 Abbreviation 
                 Structural formula 
                 Name 
                 CAS No. 
               
               
                   
               
             
            
               
                 Fmoc-Phe(4-CHF2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-[4- (difluoromethyl) phenyl]-2-(9H- fluoren-9-yl methoxycarbonyl  amino) propanoic acid 
                 1808268-08-7 
               
               
                   
               
               
                 Fmoc-Phe(2-F-3-Br)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3-bromo-2- fluorophenyl]- 2-(9H-fluoren-9-yl methoxycarbonyl  amino) propanoic acid 
                 2015410-80-5 
               
               
                   
               
               
                 Fmoc-Phe(2-F-5-Br)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(5-bromo-2- fluorophenyl]- 2-(9H-fluoren-9-yl methoxycarbonyl amino) propanoic acid 
                 1998646-62-0 
               
               
                   
               
               
                 Fmoc-Phe(3-Br)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3- bromophenyl)-2- (9H-fluoren-9-yl  methoxycarbonyl amino) propanoic acid 
                 220497-48-3 
               
               
                   
               
               
                 Fmoc-Phe(3-Br-5-F)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3-bromo-5- fluorophenyl]- 2-(9H- fluoren-9-yl methoxycarbonyl  amino) propanoic acid 
                 1998639-82-9 
               
               
                   
               
               
                 Fmoc-Phe(3-Cl-5-F)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3-chloro-5- fluorophenyl]- 2-(9H-fluoren-9-yl methoxycarbonyl  amino) propanoic acid 
                 1998650-51-3 
               
               
                   
               
               
                 Fmoc-Phe(3-CN)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3- cyanophenyl)-2- (9H-fluoren-9-yl methoxycarbonyl amino)propanoic  acid 
                 205526-36-9 
               
               
                   
               
               
                 Fmoc-Phe(4-Cl)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(4- chlorophenyl)-2- (9H-fluoren-9-yl  methoxycarbonyl amino)propanoic acid 
                 175453-08-4 
               
               
                   
               
               
                 Fmoc—(Me)Abu-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-2- methylbutanoic  acid 
                 857478-30-9 
               
               
                   
               
               
                 Fmoc—(Me)Algly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-2- methyl pent-4- enoic acid 
                 288617-71-0 
               
               
                   
               
               
                 Fmoc—(Me)Leu-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-2, 4-dimethyl  pentanoic acid 
                 312624-65-0 
               
               
                   
               
               
                 Fmoc—(Me)Phe_OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-2- methyl-3-phenyl  propanoic acid 
                 135944-05-7 
               
               
                   
               
               
                 Fmoc-1-ACPrC—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1-(9H-fluoren-9-yl  methoxycarbonyl amino)cyclopropan- 1-carboxylic acid 
                 126705-22-4 
               
               
                   
               
               
                 Fmoc-Abu-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino) butanoic acid 
                 135112-27-5 
               
               
                   
               
               
                 Fmoc-Abu(4-F3)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)- 4,4,4- trifluorobutanoic  acid 
                 181128-48-3 
               
               
                   
               
               
                 Fmoc-Ahp(2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino) heptanoic acid 
                 1197020-22-6 
               
               
                   
               
               
                 Fmoc-Ahpe(2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino) hept-6-enoic acid 
                 856412-22-1 
               
               
                   
               
               
                 Fmoc-Aib-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(9H-fluoren-9-yl  methoxycarbonyl amino)- 2-methyl  propanoic acid 
                 94744-50-0 
               
               
                   
               
               
                 Fmoc-Ala-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino) propanoic acid 
                 35661-39-3 
               
               
                   
               
               
                 Fmoc-Ala(cBu)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyclobutyl- 2-(9H- fluoren-9-yl  methoxycarbonyl amino)propanoic acid 
                 478183-62-9 
               
               
                   
               
               
                 Fmoc-Ala(CN)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyano-2- (9H-fluoren-9-yl  methoxycarbonyl amino) propanoic acid 
                 127273-06-7 
               
               
                   
               
               
                 Fmoc-Ala(cPent)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyclopentyl-2- (9H-fluoren-9-yl methoxycarbonyl amino) propanoic acid 
                 371770-32-0 
               
               
                   
               
               
                 Fmoc-Ala(cPr)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyclopropyl- 2-(9H- fluoren-9-yl methoxycarbonyl amino) propanoic acid 
                 214750-76-2 
               
               
                   
               
               
                 Fmoc-Algly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino) pent-4-enoic acid 
                 146549-21-5 
               
               
                   
               
               
                 Fmoc-AllylGly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[9H-fluoren-9-yl  methoxycarbonyl (prop-2-enyl)amino] acetic acid 
                 222725-35-1 
               
               
                   
               
               
                 Fmoc-Athpc-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(9H-fluoren-9-yl  methoxycarbonyl- amino) oxan-4- carboxylic acid 
                 285996-72-7 
               
               
                   
               
               
                 Fmoc-Aze(2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-1-(9H- fluoren-9-yl methoxycarbonyl) azetidin-2- carboxylic acid 
                 136552-06-2 
               
               
                   
               
               
                 Fmoc_bAla_OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-(9H-fluoren-9-yl  methoxycarbonyl amino) propanoic acid 
                 35737-10-1 
               
               
                   
               
               
                 Fmoc-bMeAla-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-[9H-fluoren-9-yl  methoxycarbonyl (methyl)amino] propanoic acid 
                 172965-84-3 
               
               
                   
               
               
                 Fmoc-BnGly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[benzyl(9H- fluoren-9-yl methoxy carbonyl) amino] acetic acid 
                 141743-13-7 
               
               
                   
               
               
                 Fmoc-Cha-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyclohexyl- 2-(9H- fluoren-9-yl  methoxycarbonyl amino) propanoic acid 
                 135673-97-1 
               
               
                   
               
               
                 Fmoc-cHex-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1 -(9H-fluoren-9-yl  methoxycarbonyl  amino)cyclohexan-1- carboxylic acid 
                 162648-54-6 
               
               
                   
               
               
                 Fmoc-Chg-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-cyclohexyl- 2-(9H- fluoren-9-yl  methoxycarbonyl amino)acetic acid 
                 161321-36-4 
               
               
                   
               
               
                 Fmoc-cLeu-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1-(9H-fluoren-9-yl methoxycarbonyl amino)cyclo pentan-1- carboxylic acid 
                 117322-30-2 
               
               
                   
               
               
                 Fmoc-cVal-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1 -(9H-fluoren-9-yl  methoxycarbonyl- amino) cyclobutan-1- carboxylic acid 
                 885951-77-9 
               
               
                   
               
               
                 Fmoc—D—(Me)Abu-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2R)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-2- methylbutanoic  acid 
                 1231709-22-0 
               
               
                   
               
               
                 Fmoc—D—(Me)Algly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2R)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-2- methylpent-4-enoic acid 
                 288617-76-5 
               
               
                   
               
               
                 Fmoc—D-Ala-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2R)-2-(9H- fluoren-9-yl methoxycarbonyl amino) propanoic acid 
                 79990-15-1 
               
               
                   
               
               
                 Fmoc—D-Algly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2R)-2-(9H- fluoren-9-yl methoxycarbonyl  amino) pent-4-enoic acid 
                 170642-28-1 
               
               
                   
               
               
                 Fmoc—D—MeAbu-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2R)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl) amino]butanoic acid 
                 1210830-60-6 
               
               
                   
               
               
                 Fmoc—D—MeAla-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2R)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino] propanoic acid 
                 138774-92-2 
               
               
                   
               
               
                 Fmoc—D—MePhe-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2R)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]-3- phenyl propanoic acid 
                 138775-05-0 
               
               
                   
               
               
                 Fmoc—D-Mor(3)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3R)-4-(9H- fluoren-9-yl methoxycarbonyl) morpholin-3- carboxylic acid 
                 942153-03-9 
               
               
                   
               
               
                 Fmoc—D-Pic(2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2R)-1-(9H- fluoren-9-yl methoxycarbonyl) piperidin-2- carboxylic acid 
                 101555-63-9 
               
               
                   
               
               
                 Fmoc-D-Pro-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2R)-1-(9H- fluoren-9-yl methoxycarbonyl) pyrrolidin-2- carboxylic acid 
                 101555-62-8 
               
               
                   
               
               
                 Fmoc—D-Val-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2R)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3-methyl butanoic acid 
                 84624-17-9 
               
               
                   
               
               
                 Fmoc—EtGly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[ethyl(9H- fluoren-9-yl methoxycarbonyl) amino] acetic acid 
                 162545-29-1 
               
               
                   
               
               
                 Fmoc-Glu(OAI)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-5-oxo- 5-prop-2-enoxy  pentanoic acid 
                 133464-46-7 
               
               
                   
               
               
                 Fmoc-Gly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(9H-fluoren-9-yl methoxycarbonyl  amino)acetic acid 
                 29022-11-5 
               
               
                   
               
               
                 Fmoc-Gly(cBu)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-cyclobutyl- 2-(9H- fluoren-9-yl  methoxycarbonyl amino)acetic acid 
                 1391630-31-1 
               
               
                   
               
               
                 Fmoc-Gly(cPent)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-cyclopentyl- 2-(9H- fluoren-9-yl  methoxycarbonyl amino)acetic acid 
                 220497-61-0 
               
               
                   
               
               
                 Fmoc-Gly(cPr)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-cyclopropyl- 2-(9H- fluoren-9-yl  methoxycarbonyl amino)acetic acid 
                 1212257-18-5 
               
               
                   
               
               
                 Fmoc-Hle-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-5- methyl hexanoic acid 
                 180414-94-2 
               
               
                   
               
               
                 Fmoc-Hph-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-4- phenyl butanoic acid 
                 132684-59-4 
               
               
                   
               
               
                 Fmoc—Hph(34-Cl2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-4-(3,4- dichlorophenyl)-2- (9H-fluoren-9-yl  methoxycarbonyl amino)butanoic acid 
                 1260616-12-3 
               
               
                   
               
               
                 Fmoc—Hph(3-F)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl amino)-4- (3-fluorophenyl) butanoic acid 
                 1260594-44-2 
               
               
                   
               
               
                 Fmoc—Hph(4-CF3)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-4- [4-(trifluoromethyl) phenyl] butanoic acid 
                 1260591-49-8 
               
               
                   
               
               
                 Fmoc—Hph(4-F)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-4- (4-fluorophenyl) butanoic acid 
                 1260608-85-2 
               
               
                   
               
               
                 Fmoc—Hph(4-Me)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-4- (4-methyl phenyl) butanoic acid 
                 1260587-57-2 
               
               
                   
               
               
                 Fmoc—Hse(Me)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-4- methoxybutanoic acid 
                 173212-86-7 
               
               
                   
               
               
                 Fmoc—iBuGly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[9H-fluoren-9-yl methoxycarbonyl (2-methyl propyl) amino] acetic acid 
                 141743-14-8 
               
               
                   
               
               
                 Fmoc-IDC-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-1-(9H- fluoren-9-yl methoxycarbonyl)- 2,3-dihydroindol- 2-carboxylic acid 
                 198560-38-2 
               
               
                   
               
               
                 Fmoc_Ile_OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,3S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3-methyl  pentanoic acid 
                 71989-23-6 
               
               
                   
               
               
                 Fmoc-Leu-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-4-methyl  pentanoic acid 
                 35661-60-0 
               
               
                   
               
               
                 Fmoc-Lys(Alloc)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl amino)-6- (prop-2-enoxycarbonyl amino) hexanoic acid 
                 146982-27-6 
               
               
                   
               
               
                 Fmoc—MeAbu-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl) amino] butanoic acid 
                 1310575-53-1 
               
               
                   
               
               
                 Fmoc—MeAib-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[9H-fluoren-9-yl methoxycarbonyl (methyl)amino]-2- methyl propanoic acid 
                 400779-65-9 
               
               
                   
               
               
                 Fmoc—MeAla-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino] propanoic acid 
                 84000-07-7 
               
               
                   
               
               
                 Fmoc—MeCha-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyclohexyl- 2-[9H- fluoren-9-yl  methoxycarbonyl (methyl)amino] propanoic acid 
                 148983-03-3 
               
               
                   
               
               
                 Fmoc—MeChg-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-cyclohexyl- 2-[9H- fluoren-9-yl  methoxycarbonyl (methyl)amino] acetic acid 
                 925240-97-7 
               
               
                   
               
               
                 Fmoc—MeGly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[9H-fluoren-9-yl  methoxycarbonyl (methyl)amino]  acetic acid 
                 77128-70-2 
               
               
                   
               
               
                 Fmoc—MeIle-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,3S)-2-[9H -fluoren-9-yl methoxycarbonyl (methyl) amino]-3-methyl  pentanoic acid 
                 138775-22-1 
               
               
                   
               
               
                 Fmoc—MeLeu-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]- 4-methyl  pentanoic acid 
                 103478-62-2 
               
               
                   
               
               
                 Fmoc—MeNle-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino] hexanoic acid 
                 112883-42-8 
               
               
                   
               
               
                 Fmoc—MeNva-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino] pentanoic acid 
                 252049-05-1 
               
               
                   
               
               
                 Fmoc—MePhe-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]- 3-phenyl  propanoic acid 
                 77128-73-5 
               
               
                   
               
               
                 Fmoc—MePhe(3-Me)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl) amino]-3-(3 -methyl phenyl) propanoic acid 
                 absent 
               
               
                   
               
               
                 Fmoc—Met(O2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl amino) -4-methyl sulfonyl  butanoic acid 
                 163437-14-7 
               
               
                   
               
               
                 Fmoc—Methagly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl amino) -4-methyl pent- 4-enoic acid 
                 87720-55-6 
               
               
                   
               
               
                 Fmoc—MeThr-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,3R)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]- 3-hydroxybutanoic acid 
                 252049-06-2 
               
               
                   
               
               
                 Fmoc—MeThr(Bn)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,3R)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl) amino]-3-phenyl  methoxy butanoic acid 
                 198561-81-8 
               
               
                   
               
               
                 Fmoc—MeTyr(Me)_OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl) amino]-3-(4- methoxyphenyl) propanoic acid 
                 1260595-45-6 
               
               
                   
               
               
                 Fmoc—MeVal-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]- 3-methyl  butanoic acid 
                 84000-11-3 
               
               
                   
               
               
                 Fmoc_Mor(3)_OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-4-(9H- fluoren-9-yl methoxycarbonyl) morpholin-3- carboxylic acid 
                 281655-37-6 
               
               
                   
               
               
                 Fmoc-Nle-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl amino) hexanoic acid 
                 77284-32-3 
               
               
                   
               
               
                 Fmoc-Nva-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl amino) pentanoic acid 
                 135112-28-6 
               
               
                   
               
               
                 Fmoc-Nva(3-Et)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-ethyl-2- (9H-fluoren-9-yl  methoxycarbonyl amino) pentanoic acid 
                 1310680-47-7 
               
               
                   
               
               
                 Fmoc-Oic-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,3aS,7aS)-1 - (9H-fluoren-9-yl methoxycarbonyl)- 2,3,3a,4,5,6,7,7a- octahydroindol-2- carboxylic acid 
                 130309-37-4 
               
               
                   
               
               
                 Fmoc-Phe-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3- phenyl propanoic  acid 
                 35661-40-6 
               
               
                   
               
               
                 Fmoc-Phe(23-F2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(2,3- difluorophenyl)-2- (9H-fluoren-9-yl  methoxy carbonyl amino) propanoic acid 
                 1260605-30-8 
               
               
                   
               
               
                 Fmoc-Phe(2-CF3)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3- [2-(trifluoromethyl) phenyl] propanoic acid 
                 352523-16-1 
               
               
                   
               
               
                 Fmoc-Phe(2-Cl)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(2- chlorophenyl)-2- (9H-fluoren-9-yl  methoxycarbonyl amino)propanoic  acid 
                 198560-41-7 
               
               
                   
               
               
                 Fmoc-Phe(2-F)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3- (2-fluorophenyl) propanoic acid 
                 205526-26-7 
               
               
                   
               
               
                 Fmoc-Phe(2-Me)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3- (2-methyl phenyl)  propanoic acid 
                 211637-75-1 
               
               
                   
               
               
                 Fmoc-Phe(2-OCF3)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3-[2- (trifluoromethoxy) phenyl] propanoic acid 
                 1260593-24-5 
               
               
                   
               
               
                 Fmoc-Phe(2-OMe)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3- (2-methoxyphenyl) propanoic acid 
                 206060-41-5 
               
               
                   
               
               
                 Fmoc-Phe(35-F2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3,5- difluorophenyl)- 2-(9H-fluoren-9-yl methoxy carbonyl amino) propanoic acid 
                 205526-24-5 
               
               
                   
               
               
                 Fmoc-Phe(3-CF3)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3-[3- (trifluoromethyl) phenyl] propanoic acid 
                 205526-27-8 
               
               
                   
               
               
                 Fmoc-Phe(3-Cl)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3- chlorophenyl)-2- (9H-fluoren-9-yl methoxycarbonyl amino) propanoic acid 
                 198560-44-0 
               
               
                   
               
               
                 Fmoc-Phe(3-F)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3- (3-fluorophenyl) propanoic acid 
                 198560-68-8 
               
               
                   
               
               
                 Fmoc-Phe(3-I)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3- (3-iodophenyl) propanoic acid 
                 210282-31-8 
               
               
                   
               
               
                 Fmoc-Phe(3-Me)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3- (3-methyl phenyl) propanoic acid 
                 211637-74-0 
               
               
                   
               
               
                 Fmoc-Phe(3-OCF3)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren- 9-yl methoxycarbonyl  amino)- 3-[3- trifluoromethoxy) phenyl] propanoic acid 
                 1260592-32-2 
               
               
                   
               
               
                 Fmoc-Phe(3-OMe)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3- (3-methoxyphenyl) propanoic acid 
                 206060-40-4 
               
               
                   
               
               
                 Fmoc-Phe(4-CF3)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)- 3-[4- (trifluoromethyl) phenyl] propanoic acid 
                 247113-86-6 
               
               
                   
               
               
                 Fmoc-Phe(4-F)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)-3- (4-fluorophenyl) propanoic acid 
                 169243-86-1 
               
               
                   
               
               
                 Fmoc-Phe(4-Me)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)- 3-(4-methyl phenyl) propanoic acid 
                 199006-54-7 
               
               
                   
               
               
                 Fmoc-Phe3-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)- 5-phenyl pentanoic  acid 
                 959578-11-1 
               
               
                   
               
               
                 Fmoc-Pic(2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-1-(9H- fluoren-9-yl methoxycarbonyl) piperidin-2- carboxylic acid 
                 86069-86-5 
               
               
                   
               
               
                 Fmoc-Pic(2)(4-Oxo)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-1-(9H- fluoren-9-yl methoxycarbonyl)-4- oxopiperidin-2- carboxylic acid 
                 1221793-43-6 
               
               
                   
               
               
                 Fmoc-PRA-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino) pent-4-ynoic acid 
                 198561-07-8 
               
               
                   
               
               
                 Fmoc-Pregly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)- 5-methyl hex-4- enoic acid 
                 914486-08-1 
               
               
                   
               
               
                 Fmoc-Pro-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-1-(9H- fluoren-9-yl methoxycarbonyl) pyrrolidin-2- carboxylic acid 
                 71989-31-6 
               
               
                   
               
               
                 Fmoc-Pro(4-F2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-1-(9H- fluoren-9-yl methoxycarbonyl) -4,4- difluoropyrrolidin-2- carboxylic acid 
                 203866-21-1 
               
               
                   
               
               
                 Fmoc-Pro(4-keto)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-1-(9H- fluoren-9-yl methoxycarbonyl)-4- oxopyrrolidin-2- carboxylic acid 
                 223581-83-7 
               
               
                   
               
               
                 Fmoc-Pro(4R-Ph)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-1-(9H- fluoren-9-yl methoxycarbonyl)- 4-phenyl  pyrrolidin-2- carboxylic acid 
                 1093651-96-7 
               
               
                   
               
               
                 Fmoc-Pro(4S-Ph)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-1-(9H- fluoren-9-yl methoxycarbonyl)-4- phenyl pyrrolidin-2- carboxylic acid 
                 269078-71-9 
               
               
                   
               
               
                 Fmoc-Ser(Me)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)- 3-methoxypropanoic  acid 
                 159610-93-2 
               
               
                   
               
               
                 Fmoc-Thiopro-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (4R)-3-(9H- fluoren-9-yl methoxycarbonyl)- 1,3-thiazolidin-4- carboxylic acid 
                 133054-21-4 
               
               
                   
               
               
                 Fmoc-Thr(Me)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,3R)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)- 3-methoxybutanoic  acid 
                 928063-81-4 
               
               
                   
               
               
                 Fmoc-Tle-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)- 3,3-dimethyl  butanoic acid 
                 132684-60-7 
               
               
                   
               
               
                 Fmoc-Tyr(Me)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)- 3-(4-methoxyphenyl) propanoic acid 
                 77128-72-4 
               
               
                   
               
               
                 Fmoc-Val-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H- fluoren-9-yl methoxycarbonyl  amino)- 3-methyl  butanoic acid 
                 68858-20-8 
               
               
                   
               
               
                 Fmoc—MePhe(3-OMe)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl) amino]-3-(3- methoxyphenyl) propanoic acid 
                 absent 
               
               
                   
               
               
                 Fmoc—Phe(2-Cl-5-Br)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(5-bromo-2- chlorophenyl)- 2-(9H- fluoren-9-yl methoxycarbonyl  amino) propanoic acid 
                 2002401-84-3 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                 TABLE 5 
               
               
                   
               
               
                 Compound  
                   
                   
                   
               
               
                 No. 
                 Abbreviation 
                 Structural formula 
                 Name 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 aa001 
                 Fmoc-(pip(4-F2)nPr)Gly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[3-(4,4-difluoropiperidin-1-yl) propyl-(9H-fluoren-9-yl methoxycarbonyl)amino] acetic acid 
               
               
                   
               
               
                 aa002 
                 Fmoc-2-(pip-4-F2)-EtGly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[2-(4,4-difluoropiperidin-1-yl) ethyl-(9H-fluoren-9-yl methoxycarbonyl)amino] acetic acid 
               
               
                   
               
               
                 aa003 
                 Fmoc-cPrGly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[cyclopropyl(9H-fluoren-9-yl methoxycarbonyl)amino] acetic acid 
               
               
                   
               
               
                 aa004 
                 Fmoc-iPrGly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[9H-fluoren-9-yl methoxycarbonyl(propan-2-yl) amino]acetic acid 
               
               
                   
               
               
                 aa033 
                 Fmoc-MeAla(3-Pyr-4-CF3)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-[6-(trifluoromethyl) pyridin-3-yl]propanoic acid 
               
               
                   
               
               
                 aa034 
                 Fmoc-MeAla(3-Pyr-5-OMe)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(5-methoxypyridin-3- yl)propanoic acid 
               
               
                   
               
               
                 aa035 
                 Fmoc-MeAla(3-Pyr-5-Me)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(5-methyl pyridin-3-yl) propanoic acid 
               
               
                   
               
               
                 aa036 
                 Fmoc-MeAla(3-Pyr-4-OMe)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(6-methoxypyridin-3- yl)propanoic acid 
               
               
                   
               
               
                 aa037 
                 Fmoc-MeAla(3-Pyr-4-Me)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(6-methyl pyridin-3-yl) propanoic acid 
               
               
                   
               
               
                 aa038 
                 Fmoc-Ala(3-Pyr-5-Br)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(5-bromopyridin-3- yl)-2-[9H-fluorene-9-yl methoxycarbonylamino] propanoic acid 
               
               
                   
               
               
                 aa039 
                 Fmoc-MeAbu(3-Pyr)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-4-pyridin-3-yl butanoic acid 
               
               
                   
               
               
                 aa040 
                 Fmoc-MeAbu(4-Pyr)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-4-pyridin-4-yl butanoic acid 
               
               
                   
               
               
                 aa041 
                 Fmoc-Ser(cPr)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyclopropyloxy-2-(9H- fluoren-9-yl methoxycarbonyl amino) propanoic acid 
               
               
                   
               
               
                 aa042 
                 Fmoc-MeSer(cBu)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyclobutyloxy-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]propanoic acid 
               
               
                   
               
               
                 aa043 
                 Fmoc-Ser(cBu)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyclobutyloxy-2-(9H- fluoren-9-yl methoxy carbonyl amino)propanoic acid 
               
               
                   
               
               
                 aa044 
                 Fmoc-Ser(Tfe)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxycarbonyl amino)-3- (2,2,2-trifluoroethoxy) propanoic acidtt 
               
               
                   
               
               
                 aa045 
                 Fmoc-MeSer(Tfe)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(2,2,2-trifluoroethoxy) propanoic acid 
               
               
                   
               
               
                 aa047 
                 Fmoc-MeAbu(Aze-3-F2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-4-(3,3-difluoroazetidin-1-yl)- 2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]butanoic acid 
               
               
                   
               
               
                 aa048 
                 Fmoc-MeAlgly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]pent-4-enoic acid 
               
               
                   
               
               
                 aa049 
                 Fmoc-Hph(4-SF5)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxycarbonyl amino)-4-[4- (pentafluoro-A6-sulfanyl)phenyl] butanoic acid 
               
               
                   
               
               
                 aa050 
                 Fmoc-nPrAla-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(propyl) amino]propanoic acid 
               
               
                   
               
               
                 aa053 
                 Fmoc-Ala(B(OH)2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-borono-2-(9H-fluoren-9- yl methoxycarbonyl amino) propanoic acid 
               
               
                   
               
               
                 aa054 
                 Fmoc-D-MeSer(THP)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2R)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(oxan-2-yloxy) propanoic acid 
               
               
                   
               
               
                 aa055 
                 Fmoc-D-MeSer(iPen)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2R)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(3-methyl butoxy) propanoic acidt 
               
               
                   
               
               
                 aa060 
                 Fmoc-MePhe(3-CN)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3-cyanophenyl)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]propanoic acid 
               
               
                   
               
               
                 aa061 
                 Fmoc-MePhe(4-CN)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(4-cyanophenyl)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]propanoic acid 
               
               
                   
               
               
                 aa062 
                 Fmoc-MeSer(Me)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-methoxypropanoic acid 
               
               
                   
               
               
                 aa063 
                 Fmoc-MePhe(2-CF3)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-[2-(trifluoromethyl) phenyl]propanoic acid 
               
               
                   
               
               
                 aa064 
                 Fmoc-MePhe(2-CN)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(2-cyanophenyl)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]propanoic acid 
               
               
                   
               
               
                 aa065 
                 Fmoc-MeAla(4-Pyr)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-pyridin-4-yl propanoic acid 
               
               
                   
               
               
                 aa066 
                 Fmoc-MePhe(4-CHF2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-[4-(difluoromethyl) phenyl]-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]propanoic acid 
               
               
                   
               
               
                 aa067 
                 Fmoc-MePhe(2-OMe)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(2-methoxyphenyl) propanoic acid 
               
               
                   
               
               
                 aa068 
                 Fmoc-MeAla(3-Pyr)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-pyridin-3-yl propanoic acid 
               
               
                   
               
               
                 aa069 
                 Fmoc-MeSer(cPr)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyclopropyloxy-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]propanoic acid 
               
               
                   
               
               
                 aa070 
                 Fmoc-MeAla(cPr)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyclopropyl-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]propanoic acid 
               
               
                   
               
               
                 aa071 
                 Fmoc-MeAla(cPent)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyclopentyl-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]propanoic acid 
               
               
                   
               
               
                 aa072 
                 Fmoc-MeAla(cBu)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyclobutyl-2-[9H-fluoren- 9-yl methoxycarbonyl(methyl) amino]propanoic acid 
               
               
                   
               
               
                 aa073 
                 Fmoc-MePhe(3-CF3)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-[3-(trifluoromethyl) phenyl]propanoic acid 
               
               
                   
               
               
                 aa074 
                 Fmoc-MePhe(2-OCF3)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-[2-(trifluoromethoxy) phenyl]propanoic acid 
               
               
                   
               
               
                 aa075 
                 Fmoc-MeGly(cBu)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-cyclobutyl-2-[9H-fluoren- 9-yl methoxycarbonyl(methyl) amino]acetic acid 
               
               
                   
               
               
                 aa076 
                 Fmoc-MeAhxy(2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]hex-5-ynoic acid 
               
               
                   
               
               
                 aa077 
                 Fmoc-MePhe(2-Me)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(2-methyl phenyl) propanoic acid 
               
               
                   
               
               
                 aa078 
                 Fmoc-MeHse(Me)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-4-methoxybutanoic acid 
               
               
                   
               
               
                 aa079 
                 Fmoc-MeGly(cPent)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-cyclopentyl-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]acetic acid 
               
               
                   
               
               
                 aa080 
                 Fmoc-MePhe(3-F)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(3-fluorophenyl) propanoic acid 
               
               
                   
               
               
                 aa081 
                 Fmoc-MePhe(4-OCF3)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-[4-(trifluoromethoxy) phenyl]propanoic acid 
               
               
                   
               
               
                 aa082 
                 Fmoc-MePhe(4-F)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(4-fluorophenyl) propanoic acid 
               
               
                   
               
               
                 aa083 
                 Fmoc-MePRA-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]pent-4-ynoic acid 
               
               
                   
               
               
                 aa084 
                 Fmoc-MeHnl-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]heptanoic acid 
               
               
                   
               
               
                 aa085 
                 Fmoc-MePhe(4-Me)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(4-methyl phenyl) propanoic acid 
               
               
                   
               
               
                 aa086 
                 Fmoc-MePhe(4-Br)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(4-bromophenyl)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]propanoic acid 
               
               
                   
               
               
                 aa087 
                 Fmoc-MePhe(3-OCF3)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-[3-(trifluoromethoxy) phenyl]propanoic acid 
               
               
                   
               
               
                 aa088 
                 Fmoc-MecLeu-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]cyclopentan-1- carboxylic acid 
               
               
                   
               
               
                 aa089 
                 Fmoc-MeGly(cPr)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-cyclopropyl-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]acetic acid 
               
               
                   
               
               
                 aa090 
                 Fmoc-MePhe(4-CF3)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-[4-(trifluoromethyl) phenyl]propanoic acid 
               
               
                   
               
               
                 aa091 
                 Fmoc-MeAbu(4-F3)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-4,4,4-trifluorobutanoic acid 
               
               
                   
               
               
                 aa092 
                 Fmoc-MeMet(02)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-4-methyl sulfonyl butanoic acid 
               
               
                   
               
               
                 aa093 
                 Fmoc-MeThr(Me)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,3R)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-methoxybutanoic acid 
               
               
                   
               
               
                 aa094 
                 Fmoc-MePhe(2-Cl)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(2-chlorophenyl)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]propanoic acid 
               
               
                   
               
               
                 aa095 
                 Fmoc-MePhe(2-F)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(2-fluorophenyl) propanoic acid 
               
               
                   
               
               
                 aa096 
                 Fmoc-MePhe(4-I)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-(4-iodophenyl) propanoic acid 
               
               
                   
               
               
                 aa097 
                 Fmoc-MePhe(3-Br)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3-bromophenyl)-2-[9H- fluoren-9-yl methoxycarbonyl (methyl)amino]propanoic acid 
               
               
                   
               
               
                 aa098 
                 Fmoc-Me(Me)Phe-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-2-methyl-3- phenyl propanoic acid 
               
               
                   
               
               
                 aa033-b 
                 Fmoc-MeAsp(OAI)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-4-oxo-4-prop-2- enoxybutanoic acid 
               
               
                   
               
               
                 aa101 
                 Fmoc-cisHyp(THP)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-1-(9H-fluoren-9-yl methoxycarbonyl)-4-(oxan-2- yloxy)pyrrolidin-2-carboxylic acid 
               
               
                   
               
               
                 aa102 
                 Fmoc-Hyp(THP)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-1-(9H-fluoren-9-yl methoxycarbonyl)-4-(oxan-2- yloxy)pyrrolidin-2-carboxylic acid 
               
               
                   
               
               
                 aa104 
                 Fmoc-Phe(3-I-5-Cl)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3-chloro-5-iodophenyl) 2-(9H-fluoren-9-yl methoxycarbonyl amino) propanoic acid 
               
               
                   
               
               
                 aa105 
                 Fmoc-Phe(2-F-3-I)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxycarbonyl amino)-3-(2- fluoro-3-iodophenyl)propanoic acid 
               
               
                   
               
               
                 aa106 
                 Fmoc-Phe(3-I-5-F)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxycarbonyl amino)-3-(3- fluoro-5-iodophenyl)propanoic acid 
               
               
                   
               
               
                 aa109 
                 Fmoc-EtAla-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[ethyl(9H-fluoren-9-yl methoxycarbonyl)amino] propanoic acid 
               
               
                   
               
               
                 aa110 
                 Fmoc-EtPhe(4-Cl)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(4-chlorophenyl)-2- [ethyl(9H-fluoren-9-yl methoxycarbonyl)amino] propanoic acid 
               
               
                   
               
               
                 aa111 
                 Fmoc-EtLeu-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[ethyl(9H-fluoren-9-yl methoxycarbonyl)amino]-4- methyl pentanoic acid 
               
               
                   
               
               
                 aa112 
                 Fmoc-EtCha-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-cyclohexyl-2-[ethyl(9H- fluoren-9-yl methoxycarbonyl) amino]propanoic acid 
               
               
                   
               
               
                 aa113 
                 Fmoc-EtPhe(4-Me)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[ethyl(9H-fluoren-9-yl methoxycarbonyl)amino]-3- (4-methyl phenyl)propanoic acid 
               
               
                   
               
               
                 aa114 
                 Fmoc-EtPhe(4-CF3)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[ethyl(9H-fluoren-9-yl methoxycarbonyl)amino]-3- [4-(trifluoromethyl)phenyl] propanoic acid 
               
               
                   
               
               
                 aa116 
                 Fmoc-Phe(26-F2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(2,6-difluorophenyl)-2- (9H-fluoren-9-yl methoxycarbonyl amino) propanoic acid 
               
               
                   
               
               
                 aa118 
                 Fmoc-Phe(25-F2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(2,5-difluorophenyl)-2- (9H-fluoren-9-yl methoxycarbonyl amino) propanoic acid 
               
               
                   
               
               
                 aa119 
                 Fmoc-(Me)Phe(3-I)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxycarbonyl amino)-3- (3-iodophenyl)-2- methyl propanoic acid 
               
               
                   
               
               
                 aa120 
                 Fmoc-Phe(35-Cl2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3,5-dichlorophenyl)-2- (9H-fluoren-9-yl methoxycarbonyl amino) propanoic acid 
               
               
                   
               
               
                 aa121 
                 Fmoc-Phe(2-F-5-I)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxycarbonyl amino)-3- (2-fluoro-5-iodophenyl) propanoic acid 
               
               
                   
               
               
                 aa122 
                 Fmoc-Phe(2-Cl-5-I)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(2-chloro-5-iodophenyl)- 2-(9H-fluoren-9-yl methoxycarbonyl amino) propanoic acid 
               
               
                   
               
               
                 aa124 
                 Fmoc-Ala(2-Thie-5-Cl)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(5-chlorothiophen-2-yl)- 2-(9H-fluoren-9-yl methoxycarbonyl amino) propanoic acid 
               
               
                   
               
               
                 aa125 
                 Fmoc-Ala(2-Thie-5-Br)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(5-bromothiophen-2-yl)- 2-(9H-fluoren-9-yl methoxycarbonyl amino) propanoic acid 
               
               
                   
               
               
                 aa126 
                 Fmoc-Phe(2-Br-5-1)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(2-bromo-5-iodophenyl)- 2-(9H-fluoren-9-yl methoxycarbonyl amino) propanoic acid 
               
               
                   
               
               
                 aa127 
                 Fmoc-Phe(2-Me-5-1)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxycarbonyl amino)-3- (5-iodo-2-methyl phenyl) propanoic acid 
               
               
                   
               
               
                 aa128 
                 Fmoc-Phe(2-Me-5-Br)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(5-bromo-2-methyl phenyl)-2-(9H-fluoren-9-yl methoxycarbonyl amino) propanoic acid 
               
               
                   
               
               
                 aa130 
                 Fmoc-MeAOC(2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]octanoic acid 
               
               
                   
               
               
                 aa131 
                 Fmoc-MeHle-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-5-methyl hexanoic acid 
               
               
                   
               
               
                 aa132 
                 Fmoc-Hph(4-CF3-3-Cl)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-4-[3-chloro-4- (trifluoromethyl)phenyl]-2-(9H- fluoren-9-yl methoxycarbonyl amino) butanoic acid 
               
               
                   
               
               
                 aa133 
                 Fmoc-Hph(4-CF3-3-F)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(9H-fluoren-9-yl methoxycarbonyl amino)-4-[3- fluoro-4-(trifluoromethyl)phenyl] butanoic acid 
               
               
                   
               
               
                 aa134 
                 Fmoc-Hph(4-CF3-35-F2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-4-[3,5-difluoro-4- (trifluoromethyl)phenyl]-2- (9H-fluoren-9-yl methoxycarbonyl amino) butanoic acid 
               
               
                   
               
               
                 aa150 
                 Fmoc-MeNva(5-F2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-5,5-difluoropentanoic acid 
               
               
                   
               
               
                 aa151 
                 Fmoc-MePhe(34-F2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3,4-difluorophenyl)-2- [9H-fluoren-9-yl methoxycarbonyl(methyl) amino]propanoic acid 
               
               
                   
               
               
                 aa152 
                 Fmoc-MeAsn(pip-4-F2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-4-(4,4-difluoropiperidin-1- yl)-2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-4-oxobutanoic acid 
               
               
                   
               
               
                 aa153 
                 Fmoc-MeAsn(Aze-3-F2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-4-(3,3-difluoroazetidin-1-yl)- 2-[9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-4-oxobutanoic acid 
               
               
                   
               
               
                 aa154 
                 Fmoc-MePhe(3-D)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-[9H-fluoren-9-yl methoxycarbonyl (methyl) amino]-3-(3-iodophenyl) propanoic acid 
               
               
                   
               
               
                 aa156 
                 Fmoc-(4-Me-piz-Et)Gly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[9H-fluorene-9-yl methoxycarbonyl-[2- (4-methylpiperazin-1-yl) ethyl]amino]acetic acid 
               
               
                   
               
               
                 aa157 
                 Fmoc-(Aze(3)Et)Gly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[2-(azetidine-3-yl) ethyl-(9H-fluorene-9-yl methoxycarbonyl)amino] acetic acid 
               
               
                   
               
               
                 aa158 
                 Fmoc-(H2NEtOEt)Gly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[2-(2-aminoethoxy) ethyl-(9H-fluorene-9-yl methoxycarbonyl)amino] acetic acid 
               
               
                   
               
               
                 aa159 
                 Fmoc-(H2NnBu)Gly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[4-aminobutyl (9H-fluorene-9-yl methoxycarbonyl)amino] acetic acid 
               
               
                   
               
               
                 aa160 
                 Fmoc-(Me2NEtOEt)Gly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[2-[2-(dimethylamino) ethoxy]ethyl-(9H-fluorene- 9-yl methoxycarbonyl) amino]acetic acid 
               
               
                   
               
               
                 aa161 
                 Fmoc-(MeNEtOEt)Gly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[9H-fluorene-9-yl methoxycarbonyl-[2-[2- (methylamino)ethoxy] ethyl]amino]acetic acid 
               
               
                   
               
               
                 aa162 
                 Fmoc-(piz-Et)Gly-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[9H-fluorene-9-yl methoxycarbonyl (2-piperazin-1-yl ethyl) amino]acetic acid 
               
               
                   
               
            
           
         
       
     
     Synthesis of Fmoc Amino Acids 
     Synthesis of Compound aa001, 2-[3-(4,4-difluoropiperidin-1-yl)propyl-(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid (Fmoc-(pip(4-F2)nPr)Gly-OH) 
     
       
         
         
             
             
         
       
     
     3-Amino-1-propanol (3.85 g, 51.3 mmol) was dissolved in anhydrous tetrahydrofuran (51.2 ml) under a nitrogen atmosphere and cooled to 0° C., after which a solution of Compound aa001-a (tert-butyl bromoacetate) (5.0 g, 25.6 mmol) in anhydrous tetrahydrofuran (33.3 ml) was added dropwise. The mixture was stirred at 0° C. for 10 min and then stirred at room temperature for one hour. After cooling again to 0° C., water (81.9 ml), sodium bicarbonate (4.74 g, 56.4 mmol), and N-(9-fluorenylmethoxycarbonyloxy)succinimide (Fmoc-OSu) (17.29 g, 51.3 mmol) were sequentially added and the mixture was stirred at room temperature overnight. The mixture was cooled to 0° C. and then extracted with ethyl acetate (500 ml) and a saturated aqueous ammonium chloride solution (500 ml). The organic layer was washed with water (500 ml) and brine (500 ml), dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting concentrate was purified by normal phase chromatography (n-hexane/ethyl acetate) to give Compound aa001-b (7.37 g, 70%). 
     LCMS (ESI) m/z=434 (M+Na)+ 
     Retention time: 0.88 min (analysis condition SQDFA05) 
     Compound aa001-b (6.37 g, 15.5 mmol) was dissolved in anhydrous dichloromethane (51.6 ml), Dess-Martin periodinane (7.22 g, 17.0 mmol) was added at 0° C., and the mixture was stirred for 10 minutes and then warmed to room temperature. After one hour, the mixture was cooled to 0° C. and extracted with ethyl acetate (500 ml) and an aqueous sodium bicarbonate solution (500 ml). The organic layer was washed with an aqueous sodium thiosulfate solution (500 ml) and brine (500 ml), dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting concentrate was purified by normal phase chromatography (n-hexane/ethyl acetate) to give Compound aa001-c (5.58 g, 88%). 
     LCMS (ESI) m/z=410 (M+H)+ 
     Retention time: 0.96 min (analysis condition SQDFA05) 
     Compound aa001-c (0.97 g, 2.37 mmol) and 4,4-difluoropiperidine hydrochloride (0.44 g, 2.77 mmol) were dissolved in N,N-dimethylformamide (7.9 ml), sodium triacetoxyborohydride (0.75 g, 3.55 mmol) was added, and the mixture was stirred for 30 minutes. The reaction solution was purified by reverse phase chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa001-d (0.65 g, 49%). 
     LCMS (ESI) m/z=515.5 (M+H)+ 
     Retention time: 0.68 min (analysis condition SQDFA05) 
     Compound aa001-d (0.64 g, 1.14 mmol) was dissolved in 2,2,2-trifluoroethanol (5.7 ml), and trimethylsilyl chloride (TMSCl) (0.43 ml, 3.42 mmol) was added thereto. The mixture was stirred at room temperature for one hour, and the solvent was then evaporated under reduced pressure to give Compound aa001 (2-[3-(4,4-difluoropiperidin-1-yl)propyl-(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid, Fmoc-(pip(4-F2)nPr)Gly-OH) (0.52 g, 99%). 
     LCMS (ESI) m/z=459 (M+H)+ 
     Retention time: 0.54 min (analysis condition SQDFA05) 
     Synthesis of Compound aa002, 2-[2-(4,4-difluoropiperidin-1-yl)ethyl-(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid (Fmoc-(pip(4-F2)Et)Gly-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa002-a (8.59 g, 84%) was obtained by the same method as in the synthesis of Compound aa001-b using Compound aa001-a (tert-butyl bromoacetate) (5.00 g, 25.6 mmol) as a starting material and using 2-aminoethanol instead of 3-amino-1-propanol. 
     LCMS (ESI) m/z=420 (M+Na)+ 
     Retention time: 0.88 min (analysis condition SQDFA05) 
     Compound aa002-b was obtained as a crude product (5.58 g) under the same reaction conditions as in the synthesis of Compound aa001-c using the obtained Compound aa002-a (2.35 g, 5.91 mmol). The next reaction was performed without further purification. 
     LCMS (ESI) m/z=396 (M+H)+ 
     Retention time: 0.96 min (analysis condition SQDFA05) 
     Compound aa002-c (1.33 g, 82%) was obtained under the same reaction conditions as in the synthesis of Compound aa001-d using Compound aa002-b (2.79 g, 2.955 mmol equivalents) obtained in the above reaction. 
     LCMS (ESI) m/z=501.5 (M+H)+ 
     Retention time: 0.67 min (analysis condition SQDFA05) 
     Compound aa002 (2-[2-(4,4-difluoropiperidin-1-yl)ethyl-(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid, Fmoc-(pip(4-F2)Et)Gly-OH) (1.08 g, 99%) was obtained under the same reaction conditions as in the synthesis of Compound aa001 using the obtained Compound aa002-c (1.33 g, 2.433 mmol). 
     LCMS (ESI) m/z=445 (M+H)+ 
     Retention time: 0.58 min (analysis condition SQDFA05) 
     Synthesis of Compound aa003, 2-[cyclopropyl(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid (Fmoc-cPrGly-OH) 
     
       
         
         
             
             
         
       
     
     Cyclopropylamine (1.756 g, 30.8 mmol) was dissolved in anhydrous tetrahydrofuran (40 ml) under a nitrogen atmosphere and cooled to 0° C., after which a solution of Compound aa001-a (tert-butyl bromoacetate) (3.0 g, 15.38 mmol) in anhydrous tetrahydrofuran (THF) (10 mL) was added dropwise. The mixture was then stirred at room temperature overnight. Water (30 mL), diisopropylethylamine (DIPEA) (5.96 g, 46.1 mmol), and N-(9-fluorenylmethoxycarbonyloxy)succinimide (Fmoc-OSu) (10.38 g, 30.8 mmol) were sequentially added and the mixture was stirred at room temperature for one hour. Dimethyl sulfoxide and a 20% aqueous formic acid solution were added to the reaction solution, and the tetrahydrofuran was then evaporated under reduced pressure. The resulting concentrate was purified by reverse phase chromatography (acetonitrile with 0.1% formic acid/0.1% aqueous formic acid solution) to give Compound aa003-a (2.72 g, 45%). 
     LCMS (ESI) m/z=394 (M+H)+ 
     Retention time: 1.06 min (analysis condition SQDFA05) 
     Compound aa003-a (2.72 g, 6.91 mmol) was dissolved in 2,2,2-trifluoroethanol (TFE) (34.6 mL), and trimethylsilyl chloride (TMSCl) (2.63 ml, 20.74 mmol) was added. The mixture was stirred at room temperature for 40 minutes, and the solvent was then evaporated under reduced pressure. The resulting concentrate was purified by reverse phase chromatography (acetonitrile with 0.1% formic acid/0.1% aqueous formic acid solution) to give Compound aa003 (2-[cyclopropyl(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid, Fmoc-cPrGly-OH) (1.74 g, 75%). 
     LCMS (ESI) m/z=338 (M+H)+ 
     Retention time: 0.79 min (analysis condition SQDFA05) 
     Synthesis of Compound aa004, 2-[9H-fluoren-9-ylmethoxycarbonyl(propan-2-yl)amino]acetic acid (Fmoc-iPrGly-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa004 (2-[9H-fluoren-9-ylmethoxycarbonyl(propan-2-yl)amino]acetic acid, Fmoc-iPrGly-OH) (7.0 g, 48% through three steps) was obtained by the same method as in the synthesis of Compound aa003 using Compound aa001-a (tert-butyl bromoacetate) (6.6 g, 33.8 mmol) as a starting material and using sodium carbonate instead of DIPEA as a base for Fmoc addition in the second step. 
     LCMS (ESI) m/z=340 (M+H)+ 
     Retention time: 0.80 min (analysis condition SQDFA05) 
     Synthesis of Compound aa033, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[6-(trifluoromethyl)pyridin-3-yl]propanoic acid (Fmoc-MeAla(3-Pyr-4-CF3)-OH) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Fmoc-Asp(OAl)—OH ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-prop-2-enoxybutanoic acid, CAS No. 146982-24-3) (200 g, 506 mmol), p-toluenesulfonic acid (5.7 g, 0.05 equivalents), and paraformaldehyde (45.6 g, 3 equivalents) were mixed with toluene and the mixture was stirred at 110° C. for 16 hours. The solvent was evaporated from the reaction solution under reduced pressure, and the residue was dissolved in ethyl acetate and washed with an aqueous sodium bicarbonate solution twice. The organic layer was dried over anhydrous sodium sulfate and the solvent was then evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether, 0/100 to 30/70) to give Compound aa033-a (9H-fluoren-9-ylmethyl (4S)-5-oxo-4-(2-oxo-2-prop-2-enoxyethyl)-1,3-oxazolidine-3-carboxylate) (175 g, 85%). This was mixed with another batch synthesized in the same manner and was used for the next reaction. 
     LCMS (ESI) m/z=408 (M+H)+ 
     Retention time: 1.407 min (analysis condition SMDmethod_20) 
     A mixed solution of Compound aa033-a (100 g, 245 mmol), zinc bromide (ZnBr 2 ) (110 g, 496 mmol), and triethylsilane (TES) (56 g, 481.6 mmol) in dichloromethane (DCM) (1 L) was stirred at room temperature for 48 hours under a nitrogen atmosphere. Four batches of the reaction solution on the same scale were mixed and the solvent was evaporated under reduced pressure. The residue was dissolved in TBME and extracted with 0.5 M phosphate buffer (pH=approximately 7.5) ten times. The aqueous layers were combined, adjusted to pH 2 with 5 M aqueous hydrochloric acid, and extracted with isopropyl acetate (IPAC) twice. The organic layers were combined and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure. To remove the IPAC, TBME was added to the resulting residue and the solvent was evaporated under reduced pressure. This operation was repeated six times to give Compound aa033-b ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-prop-2-enoxybutanoic acid) (270 g, 54%). 
     LCMS (ESI) m/z=410 (M+H)+ 
     Retention time: 1.956 min (analysis condition SMDmethod_05) 
     Under a nitrogen atmosphere, a solution of tert-butyl 2,2,2-trichloroacetimidate (106.73 g, 488.5 mmol) in cyclohexane (480 mL) and boron trifluoride-diethyl ether complex (BF 3 .OEt 2 ) (346.6 mg, 2.442 mmol) were added to a solution of Compound aa033-b (100 g, 244 mmol) in DCM (240 mL) at 0° C., and the mixture was warmed to room temperature and stirred for one hour. The reaction was quenched by adding pyridine to the reaction solution, and the solid was removed by filtration. TBME was added to the filtrate and the resulting solution was sequentially washed with saturated aqueous sodium bicarbonate and brine. The organic layers were combined and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to give Compound aa033-c as a crude product (102 g, 90%). 
     LCMS (ESI) m/z=488 (M+Na)+ 
     Retention time: 1.574 min (analysis condition SMDmethod_15) 
     Under a nitrogen atmosphere, phenylsilane (2.01 g, 18.6 mmol) was added dropwise to a mixture of Compound aa033-c (12 g, 26.6 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.92 g, 0.797 mmol) in DCM (110 mL) at room temperature and the mixture was stirred for 40 minutes. The solvent was evaporated from the reaction solution under reduced pressure, and the resulting residue was dissolved in TBME and extracted with saturated aqueous sodium carbonate. The aqueous layer was adjusted to pH=2 with phosphoric acid and extracted with TBME. The resulting organic layer was washed with brine and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether, 0/100 to 40/60) to give Compound aa033-d (10.2 g, 93%). This was mixed with another batch synthesized in the same manner and was used for the next reaction. 
     LCMS (ESI) m/z=448 (M+Na)+ 
     Retention time: 2.042 min (analysis condition SMDmethod_05) 
     Compound aa033-d (200 g, 470 mmol), DCC (96.99 g, 470 mmol), and N-hydroxyphthalimide (84.35 g, 517.062 mmol) were dissolved in THF (2L), and the mixture was stirred at room temperature for one hour. The solid in the reaction solution was removed by filtration, and the solvent was evaporated from the filtrate under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether, 0/100 to 40/60) to give Compound aa033-e (1-O-tert-butyl 4-O-(1,3-dioxoisoindol-2-yl) (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]butanedioate) (200 g, 73%). 
     LCMS (ESI) m/z=593 (M+Na)+ 
     Retention time: 2.706 min (analysis condition SMDmethod_07) 1H-NMR (400 MHz, DMSO-d6) δ 8.04-7.84 (m, 6H), 7.69-7.59 (m, 2H), 7.44-7.28 (m, 4H), 4.91-4.65 (m, 1H), 4.63-4.14 (m, 3H), 3.31-3.09 (m, 1H), 3.07 (s, 2H), 2.81 (s, 3H), 1.38 (s, 9H), 1.10 (s, 4H). 
     Under a nitrogen atmosphere, nickel bromide trihydrate (NiBr 2 .3H 2 O) (0.287 g, 1.052 mmol) and 4,4′-di-tert-butyl-2,2′-bipyridyl (0.282 g, 1.052 mmol) were dissolved in DMA (16 mL) to prepare a Ni solution. 
     Under a nitrogen atmosphere, DMA (16 mL) was added to Compound aa033-e (2.0 g, 3.51 mmol), zinc powder (1.146 g, 17.53 mmol), and 5-bromo-2-(trifluoromethyl)pyridine (2.376 g, 10.52 mmol), after which the previously prepared Ni solution was added and the mixture was stirred at room temperature for 14 hours. The reaction solution was then diluted with TBME (250 mL), and the solid component was removed by filtration. The resulting TBME/DMA solution was washed with an aqueous EDTA solution (1 g dissolved in 100 mL of water) twice, and the organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid), and the fractions were lyophilized to give Compound aa033-f (1.15 g, 62.3%). 
     LCMS (ESI) m/z=527 (M+H)+ 
     Retention time: 1.08 min (analysis condition SQDFA05) 
     The obtained Compound aa033-f (1.15 g, 2.184 mmol) was dissolved in a 4N hydrochloric acid/1,4-dioxane solution (10.92 mL, 43.7 mmol), and the mixture was stirred at room temperature for 19 hours and then the reaction solution was concentrated under reduced pressure to give Compound aa033 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[6-(trifluoromethyl)pyridin-3-yl]propanoic acid, Fmoc-MeAla(3-Pyr-4-CF3)-OH) (1.20 g, quant.). 
     LCMS (ESI) m/z=471 (M+H)+ 
     Retention time: 0.87 min (analysis condition SQDFA05) 
     Herein, conversion of NH amino acid protected by Fmoc group to N-methylamino acid was carried out according to the basic two-step synthesis route provided below. Examples of synthesis by N-methylation reaction will be described herein for each amino acid, but any methods described in different parts of the present specification may be used. 
     
       
         
         
             
             
         
       
     
     Synthesis of Compound aa034, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(5-methoxypyridin-3-yl)propanoic acid (Fmoc-MeAla(3-Pyr-5-OMe)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa034-a (0.72 g, 42%) was obtained by the same method as in the synthesis of Compound aa033-f using Compound aa033-e (1-O-tert-butyl 4-O-(1,3-dioxoisoindol-2-yl) (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]butanedioate) (2 g, 3.51 mmol) and 3-bromo-5-methoxypyridine as raw materials. 
     LCMS (ESI) m/z=489 (M+H)+ 
     Retention time: 0.89 min (analysis condition SQDFA05) 
     Compound aa034 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(5-methoxypyridin-3-yl)propanoic acid, Fmoc-MeAla(3-Pyr-5-OMe)-OH) (807.4 mg, quant.) was obtained by the same method as in the synthesis of Compound aa033 using Compound aa034-a (0.72 g, 1.474 mmol) as a raw material. 
     LCMS (ESI) m/z=433 (M+H)+ 
     Retention time: 0.63 min (analysis condition SQDFA05) 
     Synthesis of Compound aa035, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(5-methylpyridin-3-yl)propanoic acid (Fmoc-MeAla(3-Pyr-5-Me)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa035-a (0.49 g, 29.6%) was obtained by the same method as in the synthesis of Compound aa033-f using Compound aa033-e (1-O-tert-butyl 4-O-(1,3-dioxoisoindol-2-yl) (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]butanedioate) (2.0 g, 3.51 mmol) and 3-bromo-5-methylpyridine as raw materials. 
     LCMS (ESI) m/z=473 (M+H)+ 
     Retention time: 0.78 min (analysis condition SQDFA05) 
     Compound aa035 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(5-methylpyridin-3-yl)propanoic acid, Fmoc-MeAla(3-Pyr-5-Me)-OH) (1.14 g, quant.) was obtained by the same method as in the synthesis of Compound aa033 using Compound aa035-a (1.03 g, 2.18 mmol) as a raw material. 
     LCMS (ESI) m/z=417 (M+H)+ 
     Retention time: 0.60 min (analysis condition SQDFA05) 
     Synthesis of Compound aa036, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(6-methoxypyridin-3-yl)propanoic acid (Fmoc-MeAla(3-Pyr-4-OMe)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa036-a (752 mg, 43.9%) was obtained by the same method as in the synthesis of Compound aa033-f using Compound aa033-e (1-O-tert-butyl 4-O-(1,3-dioxoisoindol-2-yl) (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]butanedioate) (2 g, 3.51 mmol) and 5-bromo-2-methoxypyridine as raw materials. 
     LCMS (ESI) m/z=489 (M+H)+ 
     Retention time: 1.08 min (analysis condition SQDFA05) 
     Compound aa036 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(6-methoxypyridin-3-yl)propanoic acid, Fmoc-MeAla(3-Pyr-4-OMe)-OH) (715 mg, 99%) was obtained by the same method as in the synthesis of Compound aa033 using Compound aa036-a (752 mg, 1.539 mmol) as a raw material. 
     LCMS (ESI) m/z=433 (M+H)+ 
     Retention time: 0.82 min (analysis condition SQDFA05) 
     Synthesis of Compound aa037, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(6-methylpyridin-3-yl)propanoic acid (Fmoc-MeAla(3-Pyr-4-Me)-OH) 
     
       
         
         
             
             
         
       
     
     A crude product obtained by the same method as in the synthesis of Compound aa033-f using Compound aa033-e (1-O-tert-butyl 4-O-(1,3-dioxoisoindol-2-yl) (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]butanedioate) (2 g, 3.51 mmol) and 5-bromo-2-methylpyridine as raw materials was purified by silica gel column chromatography (hexane/ethyl acetate) to give Compound aa037-a (780 mg, 47.1%). 
     LCMS (ESI) m/z=473 (M+H)+ 
     Retention time: 0.73 min (analysis condition SQDFA05) 
     Compound aa037 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(6-methylpyridin-3-yl)propanoic acid, Fmoc-MeAla(3-Pyr-4-Me)-OH) (686 mg, 92%) was obtained by the same method as in the synthesis of Compound aa033 using Compound aa037-a (780 mg, 1.65 mmol) as a raw material. 
     LCMS (ESI) m/z=417 (M+H)+ 
     Retention time: 0.56 min (analysis condition SQDFA05) 
     Synthesis of Compound aa038, (2S)-3-(5-bromopyridin-3-yl)-2-[9H-fluoren-9-ylmethoxycarbonylamino]propanoic acid (Fmoc-Ala(3-Pyr-5-Br)—OH) 
     
       
         
         
             
             
         
       
     
     Fmoc-Asp-OtBu ((3S)-3-[9H-fluoren-9-ylmethoxycarbonylamino]-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid, CAS No. 129460-09-9) (300 g, 729 mmol) and N-hydroxyphthalimide (130.8 g, 801.8 mmol) were added to THF (3 L), DCC (181.8 g, 1.1 mol) was further added thereto, and the mixture was stirred at room temperature for three hours. The solvent was evaporated from the reaction solution under reduced pressure. Toluene was added to the residue, and the solid was removed by filtration. The solvent was evaporated from the filtrate under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give Compound aa038-a (272 g, 67%). 
     LCMS (ESI) m/z=578.7 (M+Na)+ 
     Retention time: 1.728 min (analysis condition SMDmethod_08) 
     Compound aa038-b (722 mg, 30%) was obtained by the same method as in the synthesis of Compound aa033-f using Compound aa038-a (2.6 g, 4.67 mmol) and 3,5-dibromopyridine as raw materials. 
     LCMS (ESI) m/z=523 (M+H)+ 
     Retention time: 1.08 min (analysis condition SQDFA05) 
     A concentrate of Compound aa038 was obtained by the same method as in the synthesis of Compound aa033 using Compound aa038-b (722 mg, 1.379 mmol). The resulting concentrate was purified by reverse phase chromatography (acetonitrile/distilled water) to give Compound aa038 ((2S)-3-(5-bromopyridin-3-yl)-2-[9H-fluoren-9-ylmethoxycarbonylamino]propanoic acid, Fmoc-Ala(3-Pyr-5-Br)—OH) (300 mg, 40%). 
     LCMS (ESI) m/z=467 (M+H)+ 
     Retention time: 0.77 min (analysis condition SQDFA05) 
     Synthesis of Compound aa039, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-pyridin-3-ylbutanoic acid (Fmoc-MeAbu(3-Pyr)-OH) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Fmoc-Glu-OtBu ((4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid, CAS No. 84793-07-7) (175 g, 411 mmol), N-hydroxyphthalimide (67.1 g, 411 mmol), WSCI—HCl (78.85 g, 411 mmol), and DMAP (2.51 g, 20.6 mmol) were added to DMF (2 L), and the mixture was stirred at room temperature for 16 hours. 1 mol/L aqueous hydrochloric acid was added to the reaction solution, followed by extraction with TBME. The organic layers were combined, sequentially washed with water, saturated aqueous sodium bicarbonate/water (1/1), and brine, and dried over anhydrous sodium sulfate, after which the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether, 0/100 to 30/70) to give Compound aa039-a (1-O-tert-butyl 5-O-(1,3-dioxoisoindol-2-yl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioate) (105 g, 45%). 
     LCMS (ESI) m/z=593.5 (M+Na)+ 
     Retention time: 2.374 min (analysis condition SMDmethod_09) 1H-NMR (300 MHz, DMSO-d6) δ 8.00-7.91 (m, 4H), 7.85 (dd, J=23.0, 7.6 Hz, 3H), 7.75 (d, J=7.4 Hz, 2H), 7.75-7.32 (m, 4H), 4.60-4.31 (m, 2H), 4.30-4.02 (m, 2H), 3.01-2.74 (m, 2H), 2.26-1.86 (m, 2H), 1.41 (s, 9H). 
     Under a nitrogen atmosphere, nickel bromide (NiBr 2 .3H 2 O) (0.716 g, 2.63 mmol) and 4,4′-di-tert-butyl-2,2′-bipyridyl (0.706 g, 2.63 mmol) were dissolved in DMA (40 mL) to prepare a Ni solution. 
     Under a nitrogen atmosphere, DMA (40 mL) was added to Compound aa039-a (5.0 g, 8.76 mmol), zinc powder (2.86 g, 43.8 mmol), and 3-bromopyridine (2.55 mL, 26.3 mmol), after which the previously prepared Ni solution was added and the mixture was stirred at room temperature for 14 hours. The reaction solution was then diluted with TBME (150 mL), after which the resulting TBME/DMA solution was washed with an aqueous EDTA solution (16 g dissolved in 250 mL of water) and then washed with saturated aqueous sodium carbonate/water (1/1, 80 mL). The organic layer was dried over anhydrous sodium sulfate, filtered, and then concentrated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid), and the fractions were lyophilized to give Compound aa039-b (2.5 g, 62.2%). 
     LCMS (ESI) m/z=459 (M+H)+ 
     Retention time: 0.69 min (analysis condition SQDFA05) 
     The obtained Compound aa039-b (2.5 g, 5.45 mmol) was dissolved in TFE (27.3 mL), and TMSCl (2.1 mL, 16.4 mmol) was added. The reaction solution was stirred at room temperature for one hour and then concentrated under reduced pressure. The resulting residue was dissolved in TBME (1 mL) and concentrated. This operation was performed three times to give the target Compound aa039-c as a crude product (2.38 g, 99%). 
     LCMS (ESI) m/z=403.2 (M+H)+ 
     Retention time: 0.51 min (analysis condition SQDFA05) 
     The obtained Compound aa039-c (2.38 g, 5.42 mmol) and paraformaldehyde (0.488 g, 16.3 mmol) were dissolved in toluene (6.57 mL), TFA (3.76 mL, 48.8 mmol) was added, and the mixture was warmed to 40° C. The reaction solution was stirred at 40° C. for five hours and cooled to room temperature. The reaction solution was concentrated under reduced pressure to give a residue, which was then dissolved in ethyl acetate (20 mL), washed with a saturated aqueous sodium carbonate solution (20 mL), and then washed with brine (20 mL). The organic layer was dried over anhydrous sodium sulfate, filtered, and then concentrated under reduced pressure. The residue was purified by normal phase column chromatography (hexane/ethyl acetate), and the resulting fractions were concentrated to give the target Compound aa039-d (1.33 g, 59%). 
     LCMS (ESI) m/z=415(M+H)+ 
     Retention time: 0.58 min (analysis condition SQDFA05) 
     The obtained Compound aa039-d (1.33 g, 3.21 mmol) was dissolved in dichloroethane (DCE) (6.7 mL) and HCl/1,4-dioxane (4N, 6.9 mL), triethylsilane (4.58 mL, 28.9 mmol) was added, and TFA (6.68 mL, 87 mmol) was then added. The reaction solution was warmed to 70° C. and stirred for two hours. The reaction solution was cooled to room temperature and then concentrated under reduced pressure. The residue was purified by reverse phase column chromatography (acetonitrile with 0.05% TFA/distilled water with 0.05% TFA), and the fractions were lyophilized. The resulting TFA salt was desalted through purification by reverse phase column chromatography (acetonitrile/distilled water) to give Compound aa039 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-pyridin-3-ylbutanoic acid, Fmoc-MeAbu(3-Pyr)-OH) (1.01 g, 69.5%). 
     LCMS (ESI) m/z=417 (M+H)+ 
     Retention time: 0.52 min (analysis condition SQDFA05) 
     Synthesis of Compound aa040, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-pyridin-4-ylbutanoic acid (Fmoc-MeAbu(4-Pyr)-OH) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Under a nitrogen atmosphere, nickel bromide (NiBr 2 .3H 2 O) (0.615 g, 2.26 mmol) and 4,4′-di-tert-butyl-2,2′-bipyridyl (0.605 g, 2.26 mmol) were dissolved in DMA (37 mL) to prepare a Ni solution. 
     4-Bromopyridine hydrochloride (4.39 g, 22.6 mmol) was desalted by dissolving it in toluene (10 mL), a 5N aqueous sodium hydroxide solution (5 mL), and water (5 mL) and an organic layer was prepared as a 4-bromopyridine solution. 
     Under a nitrogen atmosphere, Compound aa039-a (1-O-tert-butyl 5-O-(1,3-dioxoisoindol-2-yl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioate) (4.3 g, 7.52 mmol) and zinc powder (2.46 g, 37.6 mmol) were added to DMA (37 mL), followed by stirring. The previously prepared 4-bromopyridine solution (10 mL, 22.6 mmol) was added, the previously prepared Ni solution was then added, and the mixture was stirred at room temperature for 14 hours. The reaction solution was then diluted with TBME (150 mL), after which the resulting TBME/DMA solution was washed with an aqueous EDTA·2Na solution (16 g dissolved in 250 mL of water) and then washed with saturated aqueous sodium carbonate/water (1/1, 80 mL). The organic layer was dried over anhydrous sodium sulfate, filtered, and then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate), and the fractions were concentrated under reduced pressure to give Compound aa040-a (2.7 g, 78%). 
     LCMS (ESI) m/z=459 (M+H)+ 
     Retention time: 0.65 min (analysis condition SQDFA05) 
     Compound aa040-b (2.7 g, quant.) was obtained by the same method as in the synthesis of Compound aa039-c using Compound aa040-a (2.7 g, 5.89 mmol) as a raw material. 
     LCMS (ESI) m/z=401 (M−H)− 
     Retention time: 0.55 min (analysis condition SQDFA05) 
     Compound aa040-c (1.8 g,75%) was obtained by the same method as in the synthesis of Compound aa039-d using Compound aa040-b (2.55 g, 5.81 mmol) as a raw material. 
     LCMS (ESI) m/z=415 (M+H)+ 
     Retention time: 0.55 min (analysis condition SQDFA05) 
     Compound aa040 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-pyridin-4-ylbutanoic acid, Fmoc-MeAbu(4-Pyr)-OH) (860 mg, 47%) was obtained by the same method as in the synthesis of Compound aa039 using Compound aa040-c (1.81 g, 4.37 mmol) as a raw material. 
     LCMS (ESI) m/z=417 (M+H)+ 
     Retention time: 0.51 min (analysis condition SQDFA05) 
     Synthesis of Compound aa041, (2S)-3-cyclopropyloxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (Fmoc-Ser(cPr)—OH) 
     
       
         
         
             
             
         
       
     
     Methyl (S)—N-tritylaziridine-2-carboxylate (CAS No. 75154-68-6) (50 g, 146 mmol) was added to a mixed solution of chloroform (145 mL) and methanol (145 mL), trifluoroacetic acid (TFA) (33 mL, 3 equivalents) was added dropwise at 0° C. under a nitrogen atmosphere, and the mixture was stirred for seven hours. DIPEA (127 mL, 5 equivalents) was added to the reaction solution at 0° C., a solution of fluorenylmethyloxycarbonyl chloride (Fmoc-Cl) (36 g, 139 mmol) in 1,4-dioxane (145 mL) was further added dropwise, and the mixture was stirred at 0° C. for 90 minutes under a nitrogen atmosphere. The reaction solution was concentrated under reduced pressure, diluted with ethyl acetate, and then sequentially washed with water, an aqueous ammonium chloride solution, an aqueous sodium bicarbonate solution, and brine. The resulting organic layer was dried over anhydrous sodium sulfate and the solvent was then evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether, 0/100 to 10/90) to give Compound aa041-a (1-0-(9H-fluoren-9-ylmethyl) 2-O-methyl (2S)-aziridine-1,2-dicarboxylate) (40 g, 85%). 
     LCMS (ESI) m/z=323.9 (M+H)+ 
     Retention time: 2.631 min (analysis condition SMDmethod_10) 
     Compound aa041-a (1-O-(9H-fluoren-9-ylmethyl) 2-O-methyl (2S)-aziridine-1,2-dicarboxylate) (5 g, 15.46 mmol) was dissolved in DCM (30.9 mL) under a nitrogen atmosphere, cyclopropanol (1.665 mL, 26.3 mmol) was added, and then boron trifluoride-diethyl ether complex (BF 3 .OEt 2 ) (0.291 mL, 2.319 mmol) was added with ice-cooling. The reaction solution was reacted for two hours on ice and then the reaction was quenched with water and a saturated aqueous sodium bicarbonate solution. The aqueous layer was removed by a phase separator, and the organic layer was concentrated under reduced pressure. The resulting residue was purified by column chromatography (n-hexane/ethyl acetate=4/1) to give Compound aa041-b (4.6 g, 78%). 
     LCMS (ESI) m/z=382 (M+H)+ 
     Retention time: 0.89 min (analysis condition SQDFA05) 
     Calcium chloride (20.08 g, 181 mmol) was dissolved in water (50.2 mL), lithium hydroxide monohydrate (2.024 g, 48.2 mmol) was added thereto, and the mixture was stirred at room temperature for five minutes to prepare an aqueous solution A. Compound aa041-b (4.6 g, 12.06 mmol) was dissolved in isopropanol (201 mL) and THF (50.2 mL), the previously prepared aqueous solution A was added, and the mixture was stirred at room temperature for five hours. 1 mol/L aqueous hydrochloric acid (36.2 mL) was then added to the reaction solution, after which isopropanol and THF were removed by concentration under reduced pressure. The resulting aqueous layer was diluted with water (50.2 mL) and extracted with ethyl acetate three times (total volume: 100 mL). The organic layers were washed with water and brine, dried over anhydrous sodium sulfate, and filtered, and the filtrate was then concentrated under reduced pressure. The resulting residue was washed with ethyl acetate/n-hexane (1/2, 20 v/w) to give the titled Compound aa041 ((2S)-3-cyclopropyloxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Ser(cPr)—OH) (3.5 g, 79%). 
     LCMS (ESI) m/z=368 (M+H)+ 
     Retention time: 0.78 min (analysis condition SQDFA05) 
     Synthesis of Compound aa042, (2S)-3-cyclobutyloxy-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid (Fmoc-MeSer(cBu)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa042-a was obtained as a crude product by the same method as in the synthesis of Compound aa069-b using Compound aa043 ((2S)-3-cyclobutyloxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid) (10.61 g, 27.8 mmol) as a starting material. 
     LCMS (ESI) m/z=394.5 (M+H)+ 
     Retention time: 1.01 min (analysis condition SQDFA05) 
     Compound aa042 ((2S)-3-cyclobutyloxy-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-MeSer(cBu)-OH) (10.6 g, 96% through two steps) was obtained by the same method as in the synthesis of Compound aa069 using the total amount of Compound aa042-a obtained above. 
     LCMS (ESI) m/z=396 (M+H)+ 
     Retention time: 0.87 min (analysis condition SQDFA05) 
     Synthesis of Compound aa043, (2S)-3-cyclobutyloxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (Fmoc-Ser(cBu)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa043-a (4.54 g, 74.2%) was obtained by the same method as in the synthesis of Compound aa041-b using Compound aa041-a (1-O-(9H-fluoren-9-ylmethyl) 2-O-methyl (2S)-aziridine-1,2-dicarboxylate) (5 g, 15.46 mmol) and cyclobutanol as raw materials. 
     LCMS (ESI) m/z=396 (M+H)+ 
     Retention time: 0.94 min (analysis condition SQDFA05) 
     Compound aa043 ((2S)-3-cyclobutyloxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Ser(cBu)-OH) (3.78 g, 86%) was obtained by the same method as in the synthesis of Compound aa041 using Compound aa043-a (4.54 g, 11.48 mmol) as a raw material. 
     LCMS (ESI) m/z=382 (M+H)+ 
     Retention time: 0.82 min (analysis condition SQDFA05) 
     Synthesis of Compound aa044, (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2,2,2-trifluoroethoxy)propanoic acid (Fmoc-Ser(Tfe)-OH) 
     
       
         
         
             
             
         
       
     
     2-Nitrobenzenesulfonyl chloride (NsCl) (32.37 g, 146 mmol) and L-serine methyl ester hydrochloride (25 g, 161 mmol, CAS No. 5680-80-8) were dissolved in DCM (874 mL), and DIPEA (51 mL, 292 mmol) was added at 5° C. After stirring at room temperature for one hour, the reaction solution was washed with water (440 mL) twice, washed with brine/water (1/1, 440 mL) once, and then dried over magnesium sulfate. The magnesium sulfate was filtered off and the filtrate was concentrated under reduced pressure to give Compound aa044-a (39.4 g, 89%) as a crude product. 
     LCMS (ESI) m/z=302.9 (M−H)− 
     Retention time: 0.729 min (analysis condition SMDmethod_06) 
     Compound aa044-a (23 g, 75.6 mmol) was dissolved in DCM (598 mL), and triphenylphosphine (31.7 g, 121 mmol) was added at room temperature. After cooling to −14° C., DEAD (55.0 mL, 121 mmol) was added over 10 minutes, and the mixture was then stirred at −5° C. for 50 minutes. n-Hexane (300 mL) was added and the precipitate was filtered off. The filtrate was purified by silica gel column chromatography (n-hexane/DCM=50:50 to 0:100) to give Compound aa044-b (13.3 g, 62%). 
     LCMS (ESI) m/z=287 (M+H)+ 
     Retention time: 0.872 min (analysis condition SMDmethod_06) 
     Compound aa044-b (10.7 g, 37.3 mmol) was dissolved in TFE (75 mL), boron trifluoride-diethyl ether complex (BF 3 .OEt 2 ) (0.469 mL, 3.73 mmol) was added, and the mixture was then stirred at 70° C. for 30 minutes. TFE was evaporated under reduced pressure, and the resulting crude product was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa044-c (12.3 g, 85%). 
     LCMS (ESI) m/z=387 (M+H)+ 
     Retention time: 0.72 min (analysis condition SQDFA05) 
     Compound aa044-c (12 g, 31.1 mmol) was dissolved in methanol (47 mL), and a solution of lithium hydroxide monohydrate (5.21 g, 124 mmol) in water (31 mL) was added. The reaction solution was stirred at room temperature for 90 minutes, followed by addition of formic acid (11.7 mL, 311 mmol). The reaction solution was diluted with water (30 mL) and then purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa044-d (7.90 g, 68%). 
     LCMS (ESI) m/z=373 (M+H)+ 
     Retention time: 0.63 min (analysis condition SQDFA05) 
     Compound aa044-d (7.72 g, 20.7 mmol) was dissolved in acetonitrile (104 mL), potassium carbonate (7.17 g, 51.8 mmol) and dodecanethiol (7.44 mL, 31.1 mmol) were added, and the mixture was then stirred at room temperature for 74 hours. This was diluted with water (100 mL) and washed with TBME (200 mL) twice. A solution of Fmoc-OSu (3.5 g) in 1,4-dioxane (150 mL) was added to the resulting aqueous solution, and the mixture was stirred for 25 minutes. A solution of Fmoc-OSu (700 mg) in 1,4-dioxane (10 mL) was further added, and the mixture was stirred for five minutes. A solution of Fmoc-OSu (350 mg) in 1,4-dioxane (5 mL) was further added, and the mixture was stirred for five minutes. A solution of Fmoc-OSu (350 mg) in 1,4-dioxane (5 mL) was further added, and the mixture was stirred for five minutes, after which formic acid (3.9 mL) was added and the solvent was evaporated under reduced pressure. The resulting crude product was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa044 ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2,2,2-trifluoroethoxy)propanoic acid, Fmoc-Ser(Tfe)-OH) (5.67 g, 67%). 
     LCMS (ESI) m/z=410 (M+H)+ 
     Retention time: 2.35 min (analysis condition SQDFA05long) 
     Synthesis of Compound aa045, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(2,2,2-trifluoroethoxy)propanoic acid (Fmoc-MeSer(Tfe)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa045-a was obtained as a crude product by the same method as in the synthesis of Compound aa069-b using Compound aa044 (2.00 g, 4.89 mmol) as a starting material. In addition, Compound aa045 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(2,2,2-trifluoroethoxy)propanoic acid, Fmoc-MeSer(Tfe)-OH) (1.80 g, 87% through two steps) was obtained by the same method as in the synthesis of Compound aa069. 
     LCMS (ESI) m/z=424 (M+H)+ 
     Retention time: 0.84 min (analysis condition SQDFA05) 
     Synthesis of Compound aa047, (2S)-4-(3,3-difluoroazetidin-1-yl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]butanoic acid (Fmoc-MeAbu(Aze-3-F2)-OH) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     DMF (14 mL) was added to WSCI—HCl (1.65 g, 8.59 mmol) at room temperature under a nitrogen atmosphere, and the mixture was stirred and cooled in an ice bath. HOAt (1.07 g, 7.88 mmol) and Compound aa047-a ((S)-(+)-3-(benzyloxycarbonyl)-5-oxo-4-oxazolidine acetic acid) (2 g, 7.16 mmol) were added, and the mixture was stirred at the same temperature for 20 minutes. 3,3-Difluoroazetidine hydrochloride (1.02 g, 7.88 mmol) and DIPEA (1.25 mL, 7.16 mmol) were added and the mixture was stirred at the same temperature for six hours. Hexane/ethyl acetate (1/1, 20 mL) and potassium hydrogen sulfate (0.5 M aqueous solution, 30 mL) were added to the reaction mixture. The mixture was extracted with ethyl acetate twice, and the organic layers were washed with water (40 mL), saturated aqueous sodium bicarbonate/water (1/1, 40 mL), and brine/water (1/1, 40 mL). The organic layer was dried over sodium sulfate and concentrated under reduced pressure to give Compound aa047-b (2.52 g, 99%). The crude product, Compound aa047-b, was used for the next reaction without purification. 
     LCMS (ESI) m/z=355 (M+H)+ 
     Retention time: 0.66 min (analysis condition SQDFA05) 
     Compound aa047-b (2.5 g, 7.06 mmol) was dissolved in DCM (15 mL) at room temperature under a nitrogen atmosphere, triethylsilane (TES) (3.38 mL, 21.17 mmol) and water (127 μL, 7.06 mmol) were added, and boron trifluoride-diethyl ether complex (BF 3 .OEt 2 ) (1.79 mL, 14.11 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 2 hours and 45 minutes, followed by addition of saturated aqueous ammonium chloride/water (1/1, 6 mL). The mixture was stirred for 10 minutes and then extracted with DCM, and the organic layer was washed with saturated aqueous ammonium chloride/water (1/1, 8 mL) and brine/water (1/1, 8 mL). The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The resulting crude product was dissolved in acetonitrile and washed with hexane (5 mL) twice. The acetonitrile layer was concentrated under reduced pressure, and the resulting crude product was reverse-phase purified (eluent: water containing 0.1% formic acid-acetonitrile) to give Compound aa047-c ((2S)-4-(3,3-difluoroazetidin-1-yl)-2-[methyl(phenylmethoxycarbonyl)amino]-4-oxobutanoic acid) (2.20 g, 88%). 
     LCMS (ESI) m/z=357 (M+H)+ 
     Retention time: 0.58 min (analysis condition SQDFA05) 
     1,1,3,3-Tetramethyldisiloxane (10.27 mL, 58.1 mmol) was added to a solution of Compound aa047-c (1.38 g, 3.87 mmol) and triruthenium dodecacarbonyl (Ru 3 (CO) 12 ) (0.248 g, 0.387 mmol) in THF (15 mL) at room temperature under a nitrogen atmosphere. The reaction mixture was stirred at a temperature between 35° C. and 40° C. for 2 hours and 45 minutes. The reaction solution was left to cool at room temperature and was added dropwise to 2 mol/L aqueous hydrochloric acid (5 mL) cooled and stirred in an ice bath. The mixture was stirred at the same temperature for 25 minutes and then concentrated under reduced pressure. The crude product was purified by a reverse-phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa047-d (365.2 mg, 28%). 
     LCMS (ESI) m/z=341 (M−H)− 
     Retention time: 0.39 min (analysis condition SQDFA05) 
     A suspension of Compound aa047-d (360 mg, 1.05 mmol) and 10% palladium on carbon (50 w/w % water) (72 mg) in ethanol was stirred at room temperature for 3 hours and 45 minutes under a hydrogen atmosphere, after which 10% palladium on carbon (50 w/w % water) (72 mg) was added and the mixture was stirred at room temperature for 15 hours and 15 minutes under a hydrogen atmosphere. 10% palladium on carbon (50 w/w % water) (72 mg) was further added and the mixture was stirred at room temperature for 10 hours under a hydrogen atmosphere. The reaction mixture was filtered through celite and washed with ethanol. The resulting filtrate was concentrated under reduced pressure to give Compound aa047-e (208.7 mg, 95%). The crude product, Compound aa047-e, was used for the next reaction without purification. 
     LCMS (ESI) m/z=207 (M−H)− 
     (Analysis condition SQDFA05) 
     Water (3 mL), DIPEA (0.69 mL, 3.94 mmol), and 1,4-dioxane (3 mL) were added to Compound aa047-e (205 mg, 0.985 mmol), and the mixture was stirred at room temperature. Fmoc-OSu (332 mg, 0.985 mmol) was added and the reaction mixture was stirred for about 40 minutes. Formic acid (1 mL) was added to the reaction mixture, and the mixture was purified by a reverse-phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa047 ((2S)-4-(3,3-difluoroazetidin-1-yl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]butanoic acid, Fmoc-MeAbu(Aze-3-F2)-OH) (352.7 mg, 83%). 
     LCMS (ESI) m/z=431 (M+H)+ 
     Retention time: 0.54 min (analysis condition SQDFA05) 
     Synthesis of Compound aa048, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]pent-4-enoic acid (Fmoc-MeAlgly-OH) 
     
       
         
         
             
             
         
       
     
     4N Hydrochloric acid-1,4-dioxane (8.23 ml, 32.9 mmol) was added to a solution of Compound aa048-a ((2S)-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pent-4-enoic acid and Boc-MeAlgly-OH) (1.51 g, 6.59 mmol) in dichloromethane (6 ml), and the mixture was stirred at room temperature for 3.5 hours. The reaction solution was concentrated to give Compound aa048-b as a crude product (1.55 g). The next reaction was performed without further purification. 
     LCMS (ESI) m/z=130 (M+H)+ 
     Retention time: 0.14 min (analysis condition SQDFA05) 
     Compound aa048-b (6.59 mmol) was dissolved in water (9 ml), DIPEA (5.17 ml, 29.7 mmol), 1,4-dioxane (12 ml), and Fmoc-OSu (2.223 g, 6.59 mmol) were added, and the mixture was stirred at room temperature for 30 minutes. Water (25 ml) and diethyl ether/n-hexane (1/3, 18 ml) were added to the reaction solution, and the aqueous layer was washed with diethyl ether/n-hexane (1/3, 20 ml) twice. The aqueous layer was adjusted to pH 1.4 by adding potassium hydrogen sulfate (KHSO 4 ) and extracted with ethyl acetate. The organic layer was washed with brine/water (1/1) twice and dried over sodium sulfate, and the solvent was then evaporated under reduced pressure. The resulting crude product was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa048 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]pent-4-enoic acid, Fmoc-MeAlgly-OH) (2.62 g, 85%) 
     LCMS (ESI) m/z=352 (M+H)+ 
     Retention time: 0.84 min (analysis condition SQDFA05) 
     Synthesis of Compound aa049, (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[4-(pentafluoro-λ6-sulfanyl)phenyl]butanoic acid (Fmoc-Hph(4-SF5)-OH) 
     
       
         
         
             
             
         
       
     
     DIPEA (161.5 mL, 3.00 equivalents) was added dropwise to a mixture of L-2-aminobutyric acid methyl ester hydrochloride (CAS No. 56545-22-3) (50 g, 325.51 mmol), pyridine-2-carboxylic acid (44.2 g, 359.03 mmol, 1.10 equivalents), and HATU (136.5 g, 358.99 mmol, 1.10 equivalents) in DCM (1 L) at room temperature, and the mixture was stirred for 16 hours. Water was added to the reaction solution, and the mixture was extracted with DCM three times. The organic layers were combined, sequentially washed with water and brine, and dried over anhydrous sodium sulfate, after which the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether, 0/100 to 15/85) to give Compound aa049-a (209 g). 
     LCMS (ESI) m/z=223 (M+H)+ 
     Retention time: 1.011 min (analysis condition SMDmethod_11) 
     1H-NMR (400 MHz, DMSO-d6): 8.87 (d, J=6.0 Hz, 1H), 8.70-8.68 (m, 1H), 8.06-8.00 (m, 2H), 7.66-7.63 (m, 1H), 4.49-4.44 (q, 1H), 3.67 (s, 3H), 1.99-1.83 (m, 2H), 0.90 (t, J=5.7 Hz, 3H) 
     Compound aa049-a (1.35 g, 6.07 mmol), palladium(II) acetate (Pd (OAc) 2 , 0.273 g, 1.215 mmol), silver(I) carbonate (1.675 g, 6.07 mmol), dibenzyl phosphate (0.676 g, 2.43 mmol), 4-iodophenylsulfur pentafluoride (CAS No. 286947-68-0) (5.01 g, 15.2 mmol), and 2-methyl-2-butanol (35 mL) were mixed at room temperature, and the mixture was stirred at 115° C. for 5 hours and 15 minutes. The reaction solution was left to cool to room temperature, ethyl acetate was added, and the mixture was filtered through celite. The solvent was evaporated from the filtrate under reduced pressure to give Compound aa049-b (5.55 g) as a crude product. 
     LCMS (ESI) m/z=425 (M+H)+ 
     Retention time: 0.87 min (analysis condition SQDFA05) 
     Methanesulfonic acid (6.92 g, 72 mmol) and water (8.11 mL) were sequentially added to a mixture of Compound aa049-b (2.55 g, 6 mmol equivalents) in acetic acid (8.59 mL) at room temperature, and the mixture was stirred at a temperature between 110° C. and 115° C. for 24 hours. The reaction solution was left to cool to room temperature and concentrated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa049-c (1.13 g, 62%). 
     LCMS (ESI) m/z=306 (M+H)+ 
     Retention time: 0.47 min (analysis condition SQDFA05) 
     DIPEA (0.572 mL, 3.28 mmol), 1,4-dioxane (4 mL), and Fmoc-OSu (0.442 g, 1.31 mmol) were sequentially added to a solution of Compound aa049-c (0.4 g, 1.31 mmol) in water (3 mL) at room temperature, and the mixture was stirred for one hour. Formic acid was added to the reaction solution, and the reaction solution was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa049 ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[4-(pentafluoro-λ6-sulfanyl)phenyl]butanoic acid) (0.564 g, 82%). 
     LCMS (ESI) m/z=528 (M+H)+ 
     Retention time: 0.98 min (analysis condition SQDFA05) 
     Synthesis of Compound aa050, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(propyl)amino]propanoic acid (Fmoc-nPrAla-OH) 
     
       
         
         
             
             
         
       
     
     Allyl bromide (4.74 ml, 56.0 mmol) was added to a solution of Compound aa050-a (N-carbobenzoxy-L-alanine, Z-Ala-OH, CAS No. 1142-20-7) (5 g, 22.40 mmol) in tetrahydrofuran (74.7 ml) at room temperature, after which sodium hydride (2.69 g, 67.2 mmol) was added at 10° C. or below for 15 minutes or longer. The reaction solution was stirred at 10° C. or below for one hour, after which tetrahydrofuran (THF) (74.7 ml) was added and the mixture was stirred at room temperature for 65 hours. A saturated aqueous ammonium chloride solution and water were added to the reaction solution, and the mixture was then extracted with ethyl acetate. The organic layers were combined, washed with a saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa050-b (3.91 g, 66%). 
     LCMS (ESI) m/z=264 (M+H)+ 
     Retention time: 0.68 min (analysis condition SQDFA05) 
     A suspension of Compound aa050-b (3.81 g, 14.47 mmol) and 10 wt % palladium on carbon (0.41 g) in methanol (45 ml) was stirred at room temperature for two hours under a hydrogen atmosphere. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure to give Compound aa050-c (1.72 g, 91%). 
     LCMS (ESI) m/z=132 (M+H)+ 
     Retention time: 0.13 min (analysis condition SQDFA05) 
     Compound aa050-c (1.72 g, 13.11 mmol) was suspended in water (45 ml), DIPEA (10.28 ml, 59.0 mmol), 1,4-dioxane (60 ml), and N-(9-fluorenylmethoxycarbonyloxy)succinimide (Fmoc-OSu) (4.42 g, 13.11 mmol) were added to the suspension, and then the mixture was stirred at room temperature for 30 minutes. Distilled water with 20% formic acid was added to the reaction solution, the mixture was then concentrated under reduced pressure, 1,4-dioxane was evaporated, and the resultant was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa050 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(propyl)amino]propanoic acid, Fmoc-nPrAla-OH) (3.94 g, 85%). 
     LCMS (ESI) m/z=354 (M+H)+ 
     Retention time: 0.86 min (analysis condition SQDFA05) 
     Synthesis of Compound aa053, (2S)-3-borono-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (Fmoc-Ala(B(OH)2)-OH) 
     
       
         
         
             
             
         
       
     
     A 1 M solution of lithium bis(trimethylsilyl)amide (LHMDS) in THF (78 ml, 78 mmol) was added to a solution of N-(diphenylmethylene)glycine tert-butyl (CAS No. 81477-94-3) (21 g, 71.1 mmol) in THF (237 mL) at −78° C. over 10 minutes under a nitrogen atmosphere, and the mixture was then stirred for 10 minutes. 2-(Iodomethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (22.9 g, 85 mmol) was added over 10 minutes, and the mixture was stirred for a further one hour. The reaction was quenched by adding water (300 mL), after which the reaction solution was warmed to room temperature and extracted with ethyl acetate (200 mL). The resulting organic layer was washed with brine/water (1/1, 50 mL) and dried over magnesium sulfate, and the solvent was then evaporated under reduced pressure. The resulting crude product containing Compound aa053-a was used for the next experiment without purification. 
     6 mol/L Aqueous hydrochloric acid (71 mL) was added to the crude product containing Compound aa053-a, which was then heated to 70° C., stirred for five hours. The reaction solution was cooled to room temperature and the reaction solution was then washed with dichloromethane (155 mL) twice. The resulting aqueous layer containing Compound aa053-b was used as it is for the next reaction without purification. 
     The aqueous layer containing Compound aa053-b was neutralized by adding a 6 mol/L aqueous sodium hydroxide solution at 0° C., after which dioxane (142 mL), DIPEA (37.2 mL, 214 mmol), and Fmoc-OSu (24 g, 71 mmol) were added and the mixture was stirred at room temperature for one hour. The reaction solution was concentrated under reduced pressure, then diluted with a water/acetonitrile/formic acid (25/75/0.1) solution and DMSO. The solution was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid), after which the acetonitrile was evaporated under reduced pressure and then lyophilized to give Compound aa053-c (24.8 g, 98% through three steps). 
     LCMS (ESI) m/z=354 (M−H)− 
     Retention time: 0.83 min (analysis condition SQDAA05) 
     Concentrated sulfuric acid (5.40 ml, 101 mmol) was added to a solution of Compound aa053-c (18 g, 50.7 mmol) in methanol (169 mL), and the mixture was stirred at 70° C. for 30 minutes. The reaction solution was cooled to 10° C., and water (255 mL) was then added over 30 minutes. The resulting precipitate was collected by filtration and then washed with water (54 ml) three times. The precipitate was dried to give Compound aa053-d (17.75 g, 95%). This was mixed with another lot synthesized in the same manner, and purified by following chiral column chromatography. 
     LCMS (ESI) m/z=392 (M+Na)+ 
     Retention time: 0.95 min (analysis condition SQDAA05) 
     Compound aa053-d (20.8 g) was preparatively purified by chiral column chromatography (SFC CHIRALPAK AD-H (20 mm×250 mm), CO 2 /MeOH=75/25, 15 mL/min; or LC CHIRALPAK OJ-RH (20 mm×250 mm), water/acetonitrile=55/45, 20 mL/min) to give Compound aa053-e (13.8 g). 
     Lithium hydroxide (2.41 g, 57.4 mmol) was added to a 3 mol/L aqueous calcium chloride solution (71.8 ml), and the mixture was stirred at room temperature for five minutes. Isopropyl alcohol (240 mL) and a solution of Compound aa053-f (5.30 g, 14.7 mmol) in THF (60 mL) were sequentially added to the resulting solution, and the mixture was stirred for one hour. The reaction was quenched with 5 M hydrochloric acid, the reaction solution was extracted with isopropyl acetate twice, and the resulting organic layers were dried over magnesium sulfate. The solution was filtered, and the solvent was then evaporated under reduced pressure to give Compound aa053 ((2S)-3-borono-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Ala(B(OH) 2 )—OH) (5.6 g, quant.). 
     LCMS (ESI) m/z=354 (M−H)− 
     Retention time: 0.80 min (analysis condition SQDAA05) 
     Synthesis of Compound aa054, (2R)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(oxan-2-yloxy)propanoic acid (Fmoc-D-MeSer(THP)-OH) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Toluene (4 L), paraformaldehyde (293 g, 9.77 mol), and CSA (12.1 g, 52.1 mmol) were added to Compound aa054-a ((2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoic acid, Fmoc-D-Ser(tBu)-OH, 400 g, 1.04 mol), and the mixture was stirred at 110° C. for four hours. The reaction solution was cooled to room temperature, water was added, and the mixture was extracted with ethyl acetate. The resulting organic layer was sequentially washed with an aqueous sodium bicarbonate solution and brine, and dried over sodium sulfate, after which the solvent was evaporated under reduced pressure to give Compound aa054-b as a crude product (395 g). 
     LCMS (ESI) m/z=396 (M+H)+ 
     Retention time: 2.935 min (analysis condition SMDmethod_12) 
     Compound aa054-b (100 g, 253 mmol) was dissolved in DCM/TFA (1/1, 2 L), triethylsilane (264 g, 2.27 mol) was added, and the mixture was stirred at 50° C. for four hours. The solvent was evaporated under reduced pressure to give Compound aa054-c as a crude product (96 g). This was mixed with another lot synthesized separately and was used for the next reaction. 
     LCMS (ESI) m/z=364 (M+Na)+ 
     Retention time: 2.024 min (analysis condition SMDmethod_12) 
     3,4-Dihydro-2H-pyran (310 mL, 7 equivalents) and PPTS (6.6 g, 26.4 mmol) were added to a solution of Compound aa054-c (180 g, 527 mmol) in THF (1.08 L), and the mixture was stirred at 50° C. for four hours. Water was added to the reaction solution, and the organic layer was obtained by extraction with ethyl acetate, washed with brine, and then dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give Compound aa054 as a mixture with a THP-protected carboxylic acid (327 g). This was mixed with another lot synthesized separately and was used for the next reaction. 
     Phosphate buffer (pH=8, 3 L) was added to a solution of the above mixture (490 g) in THF (3 L), and the mixture was stirred at 50° C. for four hours. The reaction solution was extracted with ethyl acetate, and the resulting organic layer was washed with brine and then dried over anhydrous sodium sulfate, after which the solvent was evaporated under reduced pressure. The resulting solid was recrystallized from ether/heptane to give Compound aa054 sodium salt (500 g). TBME (8 L) and an aqueous phosphoric acid solution (110 g/22.5 L) were added thereto and the mixture was stirred at room temperature for 20 minutes. The reaction solution was extracted with TBME, and the resulting organic layer was washed with brine and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give Compound aa054 ((2R)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(oxan-2-yloxy)propanoic acid, Fmoc-D-MeSer(THP)-OH) as a white solid (366 g, 77%). 
     LCMS (ESI) m/z=448 (M+Na)+ 
     Retention time: 2.095 min (analysis condition SMDmethod_01) 
     Synthesis of Compound aa055, (2R)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(3-methylbutoxy)propanoic acid (Fmoc-D-MeSer(iPen)-OH) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Sodium hydride (NaH) (120 g, 2.2 equivalents) was added to a solution of Compound aa055-a ((2R)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid, Boc-D-Ser-OH) (466 g, 2.27 mol) in DMF (1.5 L) at 0° C. under a nitrogen atmosphere, and the mixture was stirred for two hours. 1-Bromo-3-methyl-2-butene (372 g, 2.5 mol) was added dropwise to the reaction solution at 0° C., and the mixture was stirred at room temperature for 16 hours. Ice water was added to the reaction solution, and the mixture was adjusted to pH=2 with concentrated hydrochloric acid. The reaction solution was extracted with ethyl acetate, the organic layer was washed with water and dried over sodium sulfate, and the solvent was then evaporated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give Compound aa055-b as a red oiled substance (530 g, 85%). 
     LCMS (ESI) m/z=296 (M+Na)+ 
     Retention time: 1.259 min (analysis condition SMDmethod_15) 
     Compound aa055-b (420 g, 1.54 mol) was dissolved in methanol (3 L), ammonia (2 M methanol solution, 1.2 L, 67.7 mmol) and palladium on carbon (85 g, 0.52 equivalents) were added, and the mixture was stirred for 16 hours under a hydrogen atmosphere. The reaction solution was filtered, and the solvent was evaporated from the filtrate under reduced pressure to give Compound aa055-c as a colorless oiled substance (360 g). The resulting crude product was used for the next experiment without purification. This was mixed with another lot synthesized separately and was used for the next reaction. 
     Concentrated hydrochloric acid (1.6 L, 52.7 mol) was added to a solution of Compound aa055-c (670 g, 2.43 mol) in 1,4-dioxane (3 L), and the mixture was stirred at room temperature for four hours. The reaction solution was concentrated to give Compound aa055-d as an aqueous solution. This was adjusted to pH=7 with potassium carbonate, and diluted with 1,4-dioxane (3 L) and water (2 L). Fmoc-OSu (738 g, 2.2 mol) and potassium carbonate (677 g, 4.86 mol) were added thereto, and the mixture was stirred at room temperature for 16 hours. TBME/n-hexane (1/3, 2 L) was added to the reaction solution, and the precipitated solid was removed by filtration. The filtrate was adjusted to pH 1 with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and the solvent was then evaporated under reduced pressure to give Compound aa055-e as a white solid (450 g). The resulting crude product was used for the next experiment without purification. 
     Toluene (1.5 L), paraformaldehyde (30 g, 1.15 mol), and p-toluenesulfonic acid (4.5 g, 26 mmol) were added to Compound aa055-e (150 g, 377 mmol) under a nitrogen atmosphere, and the mixture was stirred at 110° C. for 16 hours. The reaction solution was cooled to room temperature, followed by addition of ethyl acetate. The mixture was washed with an aqueous sodium bicarbonate solution and dried over sodium sulfate, and the solvent was then evaporated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give Compound aa055-f as a white solid (110 g, 65%). 
     LCMS (ESI) m/z=410 (M+H)+ 
     Retention time: 1.556 min (analysis condition SMDmethod_15) 
     Triethylsilane (102 g, 876 mmol) was added to a solution of Compound aa055-f (120 g, 293 mmol) in DCM/TFA (1/1, 2.4 L) at room temperature under a nitrogen atmosphere, the mixture was stirred for 48 hours, and the solvent was then evaporated under reduced pressure. The resulting residue was adjusted to pH=10 by adding an aqueous potassium carbonate solution. The solution was washed with n-hexane and then adjusted to pH 1 with concentrated hydrochloric acid. The residue was dissolved in acetonitrile and washed with n-heptane. The solvent was evaporated from the resulting acetonitrile layer under reduced pressure to give Compound aa055 ((2R)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(3-methylbutoxy)propanoic acid, Fmoc-D-MeSer(iPen)-OH) as a yellow oiled substance (120 g, 98%). 
     LCMS (ESI) m/z=412 (M+H)+ 
     Retention time: 2.259 min (analysis condition SMDmethod_02) 
     Synthesis of Compound aa060, (2S)-3-(3-cyanophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid (Fmoc-MePhe(3-CN)—OH) 
     
       
         
         
             
             
         
       
     
     Paraformaldehyde (172 mg, 5.74 mmol) and trifluoroacetic acid (TFA) (1.326 mL, 17.22 mmol) were added to a solution of commercially available (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-cyanophenyl)propanoic acid (Fmoc-Phe(3-CN)—OH) (789 mg, 1.913 mmol) in toluene (5.7 mL) under a nitrogen atmosphere, and the mixture was stirred at room temperature for 5 hours and 30 minutes. The reaction solution was concentrated under reduced pressure, and diluted with dichloromethane (DCM). After the solution was washed with a saturated aqueous sodium bicarbonate solution, it was dried over anhydrous magnesium sulfate, and then filtered. The resulting solution was concentrated under reduced pressure to give a crude product, Compound aa060-b (859 mg). This was used for the next reaction without further purification. 
     Triethylsilane (TES) (2.75 mL, 17.22 mmol) and trifluoroacetic acid (TFA) (3.98 mL, 51.7 mmol) were added to a solution of the above crude product, Compound aa060-b (853 mg), in dichloroethane (DCE) (10 mL) at room temperature under a nitrogen atmosphere, and the mixture was stirred at 60° C. for five hours. The reaction solution was cooled to room temperature, and the solvent was evaporated under reduced pressure. t-Butyl methyl ether/n-hexane=1/1 was added to the resulting crude product, and the mixture was extracted with a saturated aqueous sodium bicarbonate solution five times. The resulting aqueous layer was adjusted to an acidic pH with concentrated hydrochloric acid and then extracted with ethyl acetate three times. The organic layers were washed with brine, dried over anhydrous magnesium sulfate, and filtered. The solvent was then evaporated under reduced pressure to give Compound aa060 ((2S)-3-(3-cyanophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-MePhe(3-CN)—OH) (811 mg, 99% through two steps). The obtained Compound aa060 was used for peptide synthesis without further purification. 
     LCMS (ESI) m/z=427 (M+H)+ 
     Retention time: 0.83 min (analysis condition SQDFA05) 
     Synthesis of Compound aa061, (2S)-3-(4-cyanophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid (Fmoc-MePhe(4-CN)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa061 ((2S)-3-(4-cyanophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-MePhe(4-CN)—OH) was obtained as a crude product (1.14 g, 108% through two steps) by the same method as in the synthesis of Compound aa060 using Compound aa061-a ((2S)-3-(4-cyanophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Phe(4-CN)—OH) (1 g, 2.425 mmol) as a starting material. The obtained Compound aa061 was used for peptide synthesis without further purification. 
     LCMS (ESI) m/z=427 (M+H)+ 
     Retention time: 0.82 min (analysis condition SQDFA05) 
     Synthesis of Compound aa062, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-methoxypropanoic acid (Fmoc-MeSer(Me)-OH) 
     
       
         
         
             
             
         
       
     
     Commercially available O-methyl-L-serine (H-Ser(Me)-OH) (498 mg, 4.18 mmol) and sodium carbonate (1.329 g, 12.54 mmol) were dissolved in water (8 mL), after which a solution of N-(9-fluorenylmethoxycarbonyloxy)succinimide (Fmoc-OSu) (1.41 g, 4.18 mmol) in 1,4-dioxane (12 mL) was added at room temperature and the mixture was stirred overnight. Water was added to the reaction solution, and the mixture was washed with t-butyl methyl ether/n-hexane=1/10. 1N Aqueous hydrochloric acid was added to the resulting aqueous layer until the pH was acidic, and the mixture was extracted with ethyl acetate twice. The resulting organic layers were washed with brine, dried over anhydrous magnesium sulfate, and filtered. The solvent was then evaporated under reduced pressure to give Compound aa062-a (Fmoc-Ser(Me)-OH) (1.46 g) as a crude product. The obtained Compound aa062-a was used for the next reaction without further purification. 
     Trifluoroacetic acid (TFA) (2.90 mL, 37.6 mmol) was added to a solution of the above crude product, Compound aa062-a (1.46 g), and paraformaldehyde (377 mg, 12.54 mmol) in toluene (12 mL), and the mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, after which ethyl acetate was added. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and then washed with brine. The resulting organic layer was dried over anhydrous magnesium sulfate and then filtered. The solvent was evaporated from the resulting filtrate under reduced pressure to give a crude product, Compound aa062-b (2.13 g). The obtained Compound aa062-b was used for the next reaction without further purification. 
     Triethylsilane (TES) (6.02 mL, 37.7 mmol) and trifluoroacetic acid (TFA) (8.72 mL, 113 mmol) were added to a solution of the above crude product, Compound aa062-b (2.13 g), in dichloroethane (DCE) (15 mL) at room temperature, and the mixture was stirred at 60° C. for three hours. The reaction solution was cooled to room temperature, and the solvent was evaporated under reduced pressure. t-Butyl methyl ether/n-hexane=1/4 was added to the resulting crude product, and a saturated aqueous sodium bicarbonate solution was added, resulting in formation of a white solid. The organic solvent was evaporated under reduced pressure, and dimethyl sulfoxide was added to the aqueous layer. The resulting solution was purified by reverse phase column chromatography (0.1% aqueous formic acid solution/0.1% formic acid-acetonitrile solution) to give Compound aa062 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-methoxypropanoic acid, Fmoc-MeSer(Me)-OH) (782 mg, 53% through three steps). 
     LCMS (ESI) m/z=356 (M+H)+ 
     Retention time: 0.76 min (analysis condition SQDFA05) 
     Synthesis of Compound aa063, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[2-(trifluoromethyl)phenyl]propanoic acid (Fmoc-MePhe(2-CF3)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa063-b was obtained as a crude product by the same method as in the synthesis of Compound aa060-b using Compound aa063-a ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[2-(trifluoromethyl)phenyl]propanoic acid, Fmoc-Phe(2-CF3)-OH) (1 g, 2.196 mmol) as a starting material. A crude product obtained by the same method as in the synthesis of Compound aa060 using the obtained Compound aa063-b was purified by reverse phase column chromatography (0.1% aqueous formic acid solution/0.1% formic acid-acetonitrile solution) to give Compound aa063 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[2-(trifluoromethyl)phenyl]propanoic acid, Fmoc-MePhe(2-CF3)-OH) (841 mg, 82% through two steps). 
     LCMS (ESI) m/z=470 (M+H)+ 
     Retention time: 0.95 min (analysis condition SQDFA05) 
     Synthesis of Compound aa064, (2S)-3-(2-cyanophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid (Fmoc-MePhe(2-CN)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa064-b was obtained as a crude product by the same method as in the synthesis of Compound aa060 using Compound aa064-a ((2S)-3-(2-cyanophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Phe(2-CN)—OH) (1 g, 2.425 mmol) as a starting material. A crude product obtained by the same method as in the synthesis of Compound aa060 using the obtained Compound aa064-b was purified by reverse phase column chromatography (0.1% aqueous formic acid solution/0.1% formic acid-acetonitrile solution) to give Compound aa064 ((2S)-3-(2-cyanophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-MePhe(2-CN)—OH) (529 mg, 51% through two steps). 
     LCMS (ESI) m/z=427 (M+H)+ 
     Retention time: 0.85 min (analysis condition SQDFA05) 
     Synthesis of Compound aa065, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-pyridin-4-ylpropanoic acid (Fmoc-MeAla(4-Pyr)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa065-b was obtained as a crude product by the same method as in the synthesis of Compound aa060-b using Compound aa065-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-pyridin-4-ylpropanoic acid, Fmoc-Ala(4-Pyr)-OH) (1.5 g, 3.86 mmol) as a starting material. 
     LCMS (ESI) m/z=401 (M+H)+ 
     Retention time: 0.60 min (analysis condition SQDFA05) 
     A crude product obtained by the same method as in the synthesis of Compound aa060 using the total amount of Compound aa065-b obtained above was purified by reverse phase column chromatography (0.1% aqueous formic acid solution/0.1% formic acid-acetonitrile solution) to give Compound aa065 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-pyridin-4-ylpropanoic acid, Fmoc-MeAla(4-Pyr)-OH) (1.54 g, 91% through two steps). 
     LCMS (ESI) m/z=403 (M+H)+ 
     Retention time: 0.51 min (analysis condition SQDFA05) 
     Synthesis of Compound aa066, (2S)-3-[4-(difluoromethyl)phenyl]-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid (Fmoc-MePhe(4-CHF2)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa066-b was obtained as a crude product by the same method as in the synthesis of Compound aa060-b using Compound aa066-a ((2S)-3-[4-(difluoromethyl)phenyl]-2-[9H-fluoren-9-ylmethoxycarbonylamino]propanoic acid, Fmoc-Phe(4-CHF2)-OH) (2 g, 4.57 mmol) as a starting material. A crude product obtained by the same method as in the synthesis of Compound aa060 using the obtained Compound aa066-b was purified by reverse phase column chromatography (0.1% aqueous formic acid solution/0.1% formic acid-acetonitrile solution) to give Compound aa066 ((2S)-3-[4-(difluoromethyl)phenyl]-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-MePhe(4-CHF2)-OH) (1.38 g, 67% through two steps). 
     LCMS (ESI) m/z=452 (M+H)+ 
     Retention time: 0.88 min (analysis condition SQDFA05) 
     Synthesis of Compound aa067, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(2-methoxyphenyl)propanoic acid (Fmoc-MePhe(2-OMe)-OH) 
     
       
         
         
             
             
         
       
     
     A crude product obtained by the same method as in the synthesis of Compound aa060-b using Compound aa067-a ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-methoxyphenyl)propanoic acid, Fmoc-Phe(2-OMe)-OH) (1.39 g, 3.33 mmol) as a starting material was purified by silica gel column chromatography (ethyl acetate/hexane) to give Compound aa067-b as a mixture with a dimer. 
     A crude product obtained by the same method as in the synthesis of Compound aa060 using the obtained Compound aa067-b was purified by reverse phase column chromatography (0.1% aqueous formic acid solution/0.1% formic acid-acetonitrile solution) to give Compound aa067 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(2-methoxyphenyl)propanoic acid, Fmoc-MePhe(2-OMe)-OH) (456 mg, 34% through two steps). 
     LCMS (ESI) m/z=432 (M+H)+ 
     Retention time: 0.90 min (analysis condition SQDFA05) 
     Synthesis of Compound aa068. (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-pyridin-3-ylpropanoic acid (Fmoc-MeAla(3-Pyr)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa068-b (2.95 g, 95%) was obtained by the same method as in the synthesis of Compound aa060-b using Compound aa068-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-pyridin-3-ylpropanoic acid, Fmoc-Ala(3-Pyr)-OH) (3 g, 7.72 mmol) as a starting material. 
     LCMS (ESI) m/z=401 (M+H)+ 
     Retention time: 0.64 min (analysis condition SQDFA05) 
     A crude product obtained by the same method as in the synthesis of Compound aa060 using the obtained Compound aa068-b (2.95 g) was suspended in DCM (50 mL), a 3 mol/L aqueous sodium dihydrogenphosphate solution (45 mL, containing 1.5 mol/L sodium chloride) was added, and the mixture was stirred. After removing the aqueous layer, the organic layer was washed with a 3 mol/L aqueous sodium dihydrogenphosphate solution (45 mL, containing 1.5 mol/L sodium chloride) twice. The organic layer was dried over anhydrous magnesium sulfate and the solvent was then evaporated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (water/acetonitrile) to give Compound aa068 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-pyridin-3-ylpropanoic acid, Fmoc-MeAla(3-Pyr)-OH) (2.67 g, 90%). 
     LCMS (ESI) m/z=403 (M+H)+ 
     Retention time: 0.53 min (analysis condition SQDFA05) 
     Synthesis of Compound aa069, (2S)-3-cyclopropyloxy-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid (Fmoc-MeSer(cPr)—OH) 
     
       
         
         
             
             
         
       
     
     Paraformaldehyde (1.815 g, 60.5 mmol), magnesium sulfate (2.36 g, 19.63 mmol), and boron trifluoride-diethyl ether complex (BF 3 .OEt 2 ) (1.184 mL, 9.42 mmol) were added to a solution of Compound aa041 ((2S)-3-cyclopropyloxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Ser(cPr)—OH) (2.89 g, 7.85 mmol) in DCM (87 mL) under a nitrogen atmosphere, and the mixture was stirred at room temperature for two hours. A saturated aqueous sodium bicarbonate solution was added to the reaction solution to separate the organic layer from the aqueous layer. The aqueous layer was extracted with DCM twice, the combined organic layers were washed with brine and dried over sodium sulfate, and the solvent was then evaporated under reduced pressure to give Compound aa069-b as a crude product (3.1 g, quant.). 
     LCMS (ESI) m/z=380 (M+H)+ 
     Retention time: 0.93 min (analysis condition SQDFA05) 
     Triethylsilane (3.13 mL, 19.64 mmol), water (0.141 mL, 7.85 mmol), and boron trifluoride-diethyl ether complex (BF 3 .OEt 2 ) (2.49 mL, 19.6 mmol) were added to a solution of the obtained Compound aa069-b (2.98 g, 7.85 mmol) in DCM (26.2 mL) on ice under a nitrogen atmosphere, and the mixture was stirred for two hours. A saturated aqueous ammonium chloride solution was added to the reaction solution, and the organic layer was separated. The organic layer was washed with a saturated aqueous ammonium chloride solution, then washed with brine, and concentrated under reduced pressure to give a crude product. The resulting crude product was dissolved in acetonitrile and washed with n-hexane, and the acetonitrile layer was then concentrated under reduced pressure to give Compound aa069 ((2S)-3-cyclopropyloxy-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-MeSer(cPr)—OH) (2.71 g, 90%). 
     LCMS (ESI) m/z=382 (M+H)+ 
     Retention time: 0.83 min (analysis condition SQDFA05) 
     Synthesis of Compound aa070, (2S)-3-cyclopropyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid (Fmoc-MeAla(cPr)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa070-b was obtained as a crude product (10.5 g) by the same method as in the synthesis of Compound aa069-b using Compound aa070-a ((2S)-3-cyclopropyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-Ala(cPr)—OH) (10 g, 28.5 mmol) as a starting material. 
     LCMS (ESI) m/z=364 (M+H)+ 
     Retention time: 0.95 min (analysis condition SQDFA05) 
     A crude product obtained after reaction by the same method as in the synthesis of Compound aa069 using the obtained Compound aa070-b (10.5 g) was purified by reverse phase column chromatography (0.1% formic acid-water/0.1% formic acid-acetonitrile) to give Compound aa070 ((2S)-3-cyclopropyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-MeAla(cPr)—OH) (7.82 g, 75% through two steps). 
     LCMS (ESI) m/z=366 (M+H)+ 
     Retention time: 0.87 min (analysis condition SQDFA05) 
     Synthesis of Compound aa071, (2S)-3-cyclopentyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid (Fmoc-MeAla(cPent)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa071-b was obtained as a crude product (10.5 g) by the same method as in the synthesis of Compound aa069-b using Compound aa071-a ((2S)-3-cyclopentyl-2-[9H-fluoren-9-ylmethoxycarbonylamino]propanoic acid, Fmoc-Ala(cPent)-OH) (10 g, 26.4 mmol) as a starting material. 
     LCMS (ESI) m/z=392 (M+H)+ 
     Retention time: 1.05 min (analysis condition SQDFA05) 
     A crude product obtained after reaction by the same method as in the synthesis of Compound aa069 using the obtained Compound aa071-b (10.5 g) was purified by reverse phase column chromatography (0.1% aqueous formic acid solution/0.1% formic acid-acetonitrile solution) to give Compound aa071 ((2S)-3-cyclopentyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-MeAla(cPent)-OH) (10.11 g, 96% through two steps). 
     LCMS (ESI) m/z=394 (M+H)+ 
     Retention time: 0.98 min (analysis condition SQDFA05) 
     Synthesis of Compound aa072, (2S)-3-cyclobutyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid (Fmoc-MeAla(cBu)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa072-b was obtained as a crude product (3.63 g) by the same method as in the synthesis of Compound aa069-b using Compound aa072-a ((2S)-3-cyclobutyl-2-[9H-fluoren-9-ylmethoxycarbonylamino]propanoic acid, Fmoc-Ala(cBu)-OH) (3.36 g, 9.19 mmol) as a starting material. 
     LCMS (ESI) m/z=378 (M+H)+ 
     Retention time: 1.01 min (analysis condition SQDFA05) 
     A crude product obtained after reaction by the same method as in the synthesis of Compound aa069 using the obtained Compound aa072-b (3.63 g) was purified by reverse phase column chromatography (0.1% formic acid-water/0.1% formic acid-acetonitrile) to give Compound aa072 ((2S)-3-cyclobutyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-MeAla(cBu)-OH) (3.18 g, 91% through two steps). 
     LCMS (ESI) m/z=380 (M+H)+ 
     Retention time: 0.94 min (analysis condition SQDFA05) 
     Synthesis of Compound aa073, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid (Fmoc-MePhe(3-CF3)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa073-b was obtained by the same method as in the synthesis of Compound aa069-b using Compound aa073-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-[3-(trifluoromethyl)phenyl]propanoic acid, Fmoc-Phe(3-CF3)-OH) (2 g, 4.39 mmol) as a starting material. The obtained Compound aa073-b was reacted by the same method as in the synthesis of Compound aa069 and then purified by reverse phase column chromatography (0.1% aqueous formic acid solution/0.1% formic acid-acetonitrile solution) to give Compound aa073 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid, Fmoc-MePhe(3-CF3)-OH) (1.69 g, 82%). 
     LCMS (ESI) m/z=470 (M+H)+ 
     Retention time: 0.95 min (analysis condition SQDFA05) 
     Synthesis of Compound aa074, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[2-(trifluoromethoxy)phenyl]propanoic acid (Fmoc-MePhe(2-OCF3)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa074-b was obtained as a crude product by the same method as in the synthesis of Compound aa069-b using Compound aa074-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-[2-(trifluoromethoxy)phenyl]propanoic acid, Fmoc-Phe(2-OCF3)-OH) (5 g, 10.61 mmol) as a starting material. 
     LCMS (ESI) m/z=484 (M+H)+ 
     Retention time: 1.04 min (analysis condition SQDFA05) 
     Compound aa074 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[2-(trifluoromethoxy)phenyl]propanoic acid, Fmoc-MePhe(2-OCF3)-OH) (4.77 g, 93% through two steps) was obtained by the same method as in the synthesis of Compound aa069 using the total amount of Compound aa074-b obtained above. 
     LCMS (ESI) m/z=486 (M+H)+ 
     Retention time: 0.96 min (analysis condition SQDFA05) 
     Synthesis of Compound aa075, (2S)-2-cyclobutyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]acetic acid (Fmoc-MeGly(cBu)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa075-b was obtained as a crude product by the same method as in the synthesis of Compound aa069-b using Compound aa075-a ((2S)-2-cyclobutyl-2-[9H-fluoren-9-ylmethoxycarbonylamino]acetic acid, Fmoc-Gly(cBu)-OH) (2.5 g, 7.11 mmol) as a starting material. 
     LCMS (ESI) m/z=364 (M+H)+ 
     Retention time: 0.97 min (analysis condition SQDFA05) 
     A crude product obtained after reaction by the same method as in the synthesis of Compound aa069 using the total amount of Compound aa075-b obtained above was purified by reverse phase column chromatography (0.1% aqueous formic acid solution/0.1% formic acid-acetonitrile solution) to give Compound aa075 ((2S)-2-cyclobutyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]acetic acid, Fmoc-MeGly(cBu)-OH) (2.32 g, 89% through two steps). 
     LCMS (ESI) m/z=366 (M+H)+ 
     Retention time: 0.88 min (analysis condition SQDFA05) 
     Synthesis of Compound aa076, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]hex-5-ynoic acid (Fmoc-MeAhxy(2)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa076-b was obtained as a crude product by the same method as in the synthesis of Compound aa069-b using Compound aa076-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]hex-5-ynoic acid, Fmoc-Ahxy(2)-OH) (989 mg, 2.83 mmol) as a starting material. Compound aa076 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]hex-5-ynoic acid, Fmoc-MeAhxy(2)-OH) (809 mg, 79% through two steps) was obtained by the same method as in the synthesis of Compound aa069 using the obtained Compound aa076-b. 
     LCMS (ESI) m/z=364 (M+H)+ 
     Retention time: 0.81 min (analysis condition SQDFA05) 
     Synthesis of Compound aa077, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(2-methylphenl)propanoic acid (Fmoc-MePhe(2-Me)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa077-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-(2-methylphenyl)propanoic acid, Fmoc-Phe(2-Me)-OH) (2 g, 4.98 mmol) was used as a starting material and a reaction solution was obtained by the same method as in the synthesis of Compound aa069-b. To the resulting reaction solution was added a saturated aqueous sodium bicarbonate solution. A silica gel column (2 v/w) was charged with the reaction solution, which was then eluted with DCM to give Compound aa077-b as a crude product (1.45 g). Compound aa077 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(2-methylphenyl)propanoic acid, Fmoc-MePhe(2-Me)-OH) (1.21 g, 58% through two steps) was obtained by the same method as in the synthesis of Compound aa069 using the obtained Compound aa077-b. 
     LCMS (ESI) m/z=416 (M+H)+ 
     Retention time: 0.94 min (analysis condition SQDFA05) 
     Synthesis of Compound aa078, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-methoxybutanoic acid (Fmoc-MeHse(Me)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa078-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-4-methoxybutanoic acid, Fmoc-Hse(Me)-OH) (5.0 g, 14.07 mmol), paraformaldehyde (1.27 g, 42.2 mmol), and CSA (0.163 g, 0.70 mmol) were suspended in toluene (82 mL) and stirred at 80° C. for 14 hours. The reaction solution was cooled to room temperature, after which the filtrate was diluted with ethyl acetate (100 mL) and then washed with saturated aqueous sodium bicarbonate/water (1/1) and brine/water (1/1). The organic layer was dried over anhydrous sodium sulfate, filtered, and then concentrated under reduced pressure to give Compound aa078-b as a crude product (5.1 g, 99%). 
     LCMS (ESI) m/z=368 (M+H)+ 
     Retention time: 0.84 min (analysis condition SQDFA05) 
     To a solution of the obtained Compound aa078-b (5.12 g, 13.94 mmol) in DCM (46.5 mL) were added triethylsilane (6.68 mL, 41.8 mmol), water (0.251 mL, 13.94 mmol), and boron trifluoride-diethyl ether complex (BF 3 .OEt 2 ) (3.53 mL, 27.9 mmol) under ice-cooling under a nitrogen atmosphere, and the mixture was stirred for two hours. To the reaction solution were added saturated aqueous ammonium chloride/water (1/1) and water (5 mL), and the organic layer was separated. The aqueous layer was extracted with DCM and the organic layer was washed with brine/water (1/1). The organic layer was dried over anhydrous sodium sulfate, filtered, and then concentrated under reduced pressure. The resulting compound was dissolved in acetonitrile, washed with n-hexane, and concentrated under reduced pressure to yield Compound aa078 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-methoxybutanoic acid, Fmoc-MeHse(Me)-OH) (4.9 g, 95%). 
     LCMS (ESI) m/z=370 (M+H)+ 
     Retention time: 0.76 min (analysis condition SQDFA05) 
     Synthesis of Compound aa079, (2S)-2-cyclopentyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]acetic acid (Fmoc-MeGly(cPent)-OH) 
     
       
         
         
             
             
         
       
     
     To a mixture of Compound aa079-a ((2S)-2-cyclopentyl-2-[9H-fluoren-9-ylmethoxycarbonylamino]acetic acid, Fmoc-Gly(cPent)-OH) (30.0 g, 82 mmol), paraformaldehyde (7.39 g, 246 mmol), and CSA (0.954 g, 4.10 mmol) in toluene (160 mL) was added trifluoroacetic acid (TFA) (9.0 mL), and the mixture was then stirred at 60° C. for four hours. The reaction solution was cooled to room temperature, and the solid was then removed by filtration. The filtrate was concentrated under reduced pressure, diluted with ethyl acetate (220 mL), and then sequentially washed with a saturated aqueous sodium bicarbonate solution and brine. The organic layer was dried over anhydrous sodium sulfate, filtered, and then concentrated under reduced pressure to give Compound aa079-b as a crude product. The next reaction was performed without further purification. 
     LCMS (ESI) m/z=378 (M+H)+ 
     Retention time: 1.01 min (analysis condition SQDFA05) 
     To a mixture of the total amount of Compound aa079-b obtained above and triethylsilane (TES) (65.5 mL, 410 mmol) in dichloroethane (DCE) (90 mL) was added trifluoroacetic acid (TFA) (76 mL, 984 mmol), and the mixture was stirred at 60° C. for 16 hours. The reaction solution was cooled to room temperature and then concentrated under reduced pressure, and the resulting solid was washed with n-hexane/ethyl acetate (95/5) and dried under reduced pressure to give Compound aa079 ((2S)-2-cyclopentyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]acetic acid, Fmoc-MeGly(cPent)-OH) (29.1 g, 93% through two steps). 
     LCMS (ESI) m/z=380 (M+H)+ 
     Retention time: 0.92 min (analysis condition SQDFA05) 
     Synthesis of Compound aa080, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(3-fluorophenyl)propanoic acid (Fmoc-MePhe(3-F)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa080-b was obtained as a crude product (3.78 g, quant.) by the same method as in the synthesis of Compound aa078-b using Compound aa080-a ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3-fluorophenyl)propanoic acid, Fmoc-Phe(3-F)—OH) (3.38 g, 8.34 mmol) as a starting material. 
     LCMS (ESI) m/z=418 (M+H)+ 
     Retention time: 0.98 min (analysis condition SQDFA05) 
     Compound aa080 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(3-fluorophenyl)propanoic acid, Fmoc-MePhe(3-F)—OH) (3.52 g, quant.) was obtained by the same method as in the synthesis of Compound aa078 using the obtained Compound aa080-b (3.6 g, 8.62 mmol). 
     LCMS (ESI) m/z=420 (M+H)+ 
     Retention time: 0.89 min (analysis condition SQDFA05) 
     Synthesis of Compound aa081, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[4-(trifluoromethoxy)phenyl]propanoic acid (Fmoc-MePhe(4-OCF3)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa081-b was obtained as a crude product (516 mg) by the same method as in the synthesis of Compound aa078-b using Compound aa081-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-[4-(trifluoromethoxy)phenyl]propanoic acid, Fmoc-Phe(4-OCF3)-OH) (0.5 g, 1.061 mmol) as a starting material. Compound aa081 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[4-(trifluoromethoxy)phenyl]propanoic acid, Fmoc-MePhe(4-OCF3)-OH) (462 mg, 90% through two steps) was obtained by the same method as in the synthesis of Compound aa078 using the obtained Compound aa081-b (516 mg). 
     LCMS (ESI) m/z=486 (M+H)+ 
     Retention time: 0.97 min (analysis condition SQDFA05) 
     Synthesis of Compound aa082, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(4-fluorophenyl)propanoic acid (Fmoc-MePhe(4-F)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa082-b was obtained as a crude product (8.55 g) by the same method as in the synthesis of Compound aa078-b using Compound aa082-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-(4-fluorophenyl)propanoic acid, Fmoc-Phe(4-F)—OH) (10.0 g, 24.67 mmol) as a starting material. 
     LCMS (ESI) m/z=418 (M+H)+ 
     Retention time: 0.98 min (analysis condition SQDFA05) 
     Compound aa082 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(4-fluorophenyl)propanoic acid, Fmoc-MePhe(4-F)—OH) (7.28 g, 70% through two steps) was obtained by the same method as in the synthesis of Compound aa078 using the obtained Compound aa082-b (8.55 g). 
     LCMS (ESI) m/z=420 (M+H)+ 
     Retention time: 0.90 min (analysis condition SQDFA05) 
     Synthesis of Compound aa083, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]pent-4-ynoic acid (Fmoc-MePRA-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa083-b (2.71 g, 87%) was obtained by the same method as in the synthesis of Compound aa078-b using Compound aa083-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]pent-4-ynoic acid, Fmoc-PRA-OH) (3 g, 8.95 mmol) as a starting material. 
     LCMS (ESI) m/z=348 (M+H)+ 
     Retention time: 0.87 min (analysis condition SQDFA05) 
     Compound aa083 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]pent-4-ynoic acid, Fmoc-MePRA-OH) (986 mg, 99%) was obtained by the same method as in the synthesis of Compound aa078 using the obtained Compound aa083-b (989 mg, 2.85 mmol). 
     LCMS (ESI) m/z=350 (M+H)+ 
     Retention time: 0.79 min (analysis condition SQDFA05) 
     Synthesis of Compound aa084, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]heptanoic acid (Fmoc-MeHnl-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa084-b was obtained as a crude product (5.58 g) by the same method as in the synthesis of Compound aa078-b using Compound aa084-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]heptanoic acid, Fmoc-Hnl-OH) (5 g, 13.61 mmol) as a starting material. 
     LCMS (ESI) m/z=380 (M+H)+ 
     Retention time: 1.05 min (analysis condition SQDFA05) 
     Compound aa084 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]heptanoic acid, Fmoc-MeHnl-OH) (4.869 g, 94%) was obtained by the same method as in the synthesis of Compound aa078 using the obtained Compound aa084-b (5.16 g, 12.58 mmol). 
     LCMS (ESI) m/z=382 (M+H)+ 
     Retention time: 0.97 min (analysis condition SQDFA05) 
     Synthesis of Compound aa085, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(4-methylphenyl)propanoic acid (Fmoc-MePhe(4-Me)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa085-b was obtained as a crude product (22.66 g) by the same method as in the synthesis of Compound aa078-b using Compound aa085-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-(4-methylphenyl)propanoic acid, Fmoc-Phe(4-Me)-OH) (20 g, 49.8 mmol) as a starting material. 
     LCMS (ESI) m/z=414 (M+H)+ 
     Retention time: 1.04 min (analysis condition SQDFA05) 
     A crude product obtained after reaction by the same method as in the synthesis of Compound aa078 using the obtained Compound aa085-b (22.66 g) was purified by reverse phase column chromatography (0.1% formic acid-water/0.1% formic acid-acetonitrile) to give Compound aa085 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(4-methylphenyl)propanoic acid, Fmoc-MePhe(4-Me)-OH) (17.3 g, 83.5% through two steps). 
     LCMS (ESI) m/z=416 (M+H)+ 
     Retention time: 2.41 min (analysis condition SQDFA3080) 
     Synthesis of Compound aa086, (2S)-3-(4-bromophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid (Fmoc-MePhe(4-Br)—OH) 
     
       
         
         
             
             
         
       
     
     A crude product obtained by the same method as in the synthesis of Compound aa078-b using Compound aa086-a ((2S)-3-(4-bromophenyl)-2-[9H-fluoren-9-ylmethoxycarbonylamino]propanoic acid, Fmoc-Phe(4-Br)—OH) (6 g, 12.87 mmol) as a starting material was purified by reverse phase column chromatography (0.1% aqueous formic acid/0.1% formic acid-acetonitrile) to give Compound aa086-b (3.57 g, 58%). 
     LCMS (ESI) m/z=478 (M+H)+ 
     Retention time: 1.05 min (analysis condition SQDFA05) 
     A crude product obtained by the same method as in the synthesis of Compound aa078 using the obtained Compound aa086-b (3.57 g, 7.46 mmol) was washed with acetonitrile/hexane (1/1) to give Compound aa086 ((2S)-3-(4-bromophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-MePhe(4-Br)—OH) (3.40 g, 95%). 
     LCMS (ESI) m/z=480 (M+H)+ 
     Retention time: 0.96 min (analysis condition SQDFA05) 
     Synthesis of Compound aa087, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[3-(trifluoromethoxy)phenyl]propanoic acid (Fmoc-MePhe(3-OCF3)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa087-b was obtained as a crude product (5.84 g) by the same method as in the synthesis of Compound aa078-b using Compound aa087-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-[3-(trifluoromethoxy)phenyl]propanoic acid, Fmoc-Phe(3-OCF3)-OH) (6.07 g, 12.87 mmol) as a starting material. 
     LCMS (ESI) m/z=484 (M+H)+ 
     Retention time: 1.05 min (analysis condition SQDFA05) 
     Compound aa087 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[3-(trifluoromethoxy)phenyl]propanoic acid, Fmoc-MePhe(3-OCF3)-OH) (5.66 g, 91% through two steps) was obtained by the same method as in the synthesis of Compound aa078 using the obtained Compound aa087-b (5.84 g). 
     LCMS (ESI) m/z=486 (M+H)+ 
     Retention time: 0.97 min (analysis condition SQDFA05) 
     Synthesis of Compound aa088, 1-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]cyclopentane-1-carboxylic acid (Fmoc-MecLeu-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa088-b was obtained as a crude product by the same method as in the synthesis of Compound aa078-b using Compound aa088-a (1-[9H-fluoren-9-ylmethoxycarbonylamino]cyclopentane-1-carboxylic acid, Fmoc-cLeu-OH) (10 g, 28.5 mmol) as a starting material. A crude product was obtained by the same method as in the synthesis of Compound aa078 using Compound aa088-b. The resulting crude product was purified by trituration (hexane/TBME) to give Compound aa088 (1-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]cyclopentane-1-carboxylic acid, Fmoc-MecLeu-OH) (6.82 g, 66% through two steps). 
     LCMS (ESI) m/z=366 (M+H)+ 
     Retention time: 0.87 min (analysis condition SQDFA05) 
     Synthesis of Compound aa089, (2S)-2-cyclopropyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]acetic acid (Fmoc-MeGly(cPr)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa089-b was obtained as a crude product by the same method as in the synthesis of Compound aa078-b using Compound aa089-a ((2S)-2-cyclopropyl-2-[9H-fluoren-9-ylmethoxycarbonylamino]acetic acid, Fmoc-Gly(cPr)—OH) (5 g, 14.82 mmol) as a starting material. 
     LCMS (ESI) m/z=350 (M+H)+ 
     Retention time: 0.89 min (analysis condition SQDFA05) 
     Compound aa089 ((2S)-2-cyclopropyl-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]acetic acid, Fmoc-MeGly(cPr)—OH) (5.18 g, 99% through two steps) was obtained by the same method as in the synthesis of Compound aa078 using the total amount of Compound aa089-b obtained above. 
     LCMS (ESI) m/z=352 (M+H)+ 
     Retention time: 0.80 min (analysis condition SQDFA05) 
     Synthesis of Compound aa090, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[4-(trifluoromethyl)phenyl]propanoic acid (Fmoc-MePhe(4-CF3)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa090-b was obtained as a crude product (206.8 g) by the same method as in the synthesis of Compound aa078-b using Compound aa090-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-[4-(trifluoromethyl)phenyl]propanoic acid, Fmoc-Phe(4-CF3)-OH) (200 g, 439 mmol) as a starting material. 
     LCMS (ESI) m/z=468.5 (M+H)+ 
     Retention time: 3.30 min (analysis condition SMDmethod_03) 
     Compound aa090 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[4-(trifluoromethyl)phenyl]propanoic acid, Fmoc-MePhe(4-CF3)-OH) (195 g, 95% through two steps) was obtained by the same method as in the synthesis of Compound aa078 using the obtained Compound aa090-b (205 g). 
     LCMS (ESI) m/z=469.95 (M+H)+ 
     Retention time: 2.96 min (analysis condition SMDMethod_03) 
     Synthesis of Compound aa091, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4,4,4-trifluorobutanoic acid (Fmoc-MeAbu(4-F3)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa091-b was obtained as a crude product by the same method as in the synthesis of Compound aa078-b using Compound aa091-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-4,4,4-trifluorobutanoic acid, Fmoc-Abu(4-F3)-OH) (0.994 g, 2.62 mmol) as a starting material. A crude product obtained by the same method as in the synthesis of Compound aa078 using the obtained Compound aa091-b (4.78 g), was washed with acetonitrile and filtered to collect a solid, which was then combined with a solid obtained by washing the filtrate with hexane and then evaporating the solvent from the filtrate under reduced pressure to give Compound aa091 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4,4,4-trifluorobutanoic acid, Fmoc-MeAbu(4-F3)-OH) (961 mg, 93% through two steps). 
     LCMS (ESI) m/z=394 (M+H)+ 
     Retention time: 0.83 min (analysis condition SQDFA05) 
     Synthesis of Compound aa092, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-methylsulfonylbutanoic acid (Fmoc-MeMet(O2)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa092-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-4-methylsulfonylbutanoic acid, Fmoc-Met(O2)-OH) (5.0 g, 12.39 mmol), paraformaldehyde (1.12 g, 37.2 mmol), and CSA (0.144 g, 0.62 mmol) were suspended in toluene (83 mL), and the mixture was stirred at 95° C. for four hours. The reaction solution was cooled to room temperature, after which the filtrate was diluted with ethyl acetate (100 mL) and then washed with saturated aqueous sodium bicarbonate/water (1/1) and brine/water (1/1). The organic layer was dried over anhydrous sodium sulfate, filtered, and then concentrated under reduced pressure to give Compound aa092-b (4.2 g) as a crude product. 
     LCMS (ESI) m/z=416 (M+H)+ 
     Retention time: 0.77 min (analysis condition SQDFA05) 
     To a solution of the obtained Compound aa092-b (4.20 g, 10.11 mmol) in DCM (33.7 mL) were added triethylsilane (4.84 mL, 30.3 mmol), water (0.182 mL, 10.11 mmol), and boron trifluoride-diethyl ether complex (BF 3 .OEt 2 ) (2.56 mL, 20.22 mmol) under ice-cooling under a nitrogen atmosphere, and the mixture was stirred for two hours. To the reaction solution were added saturated aqueous ammonium chloride/water (1/1) and water (3 ml), and the organic layer was separated. The aqueous layer was extracted with DCM and the organic layer was washed with brine, resulting in precipitation of a solid. The precipitated compound was washed with hexane to give Compound aa092 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-methylsulfonylbutanoic acid, Fmoc-MeMet(O2)-OH) (3.64 g, 86%). 
     LCMS (ESI) m/z=418 (M+H)+ 
     Retention time: 0.68 min (analysis condition SQDFA05) 
     Synthesis of Compound aa093, (2S,3R)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-methoxybutanoic acid (Fmoc-MeThr(Me)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa093-b was obtained as a crude product by the same method as in the synthesis of Compound aa078-b using Compound aa093-a ((2S,3R)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-methoxybutanoic acid, Fmoc-Thr(Me)-OH) (3 g, 8.44 mmol) as a starting material. 
     LCMS (ESI) m/z=368 (M+H)+ 
     Retention time: 0.88 min (analysis condition SQDFA05) 
     Compound aa093 ((2S,3R)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-methoxybutanoic acid, Fmoc-MeThr(Me)-OH) (2.79 g, 89% through two steps) was obtained by the same method as in the synthesis of Compound aa078 using the total amount of Compound aa093-b obtained above. 
     LCMS (ESI) m/z=370 (M+H)+ 
     Retention time: 0.81 min (analysis condition SQDFA05) 
     Synthesis of Compound aa094, (2S)-3-(2-chlorophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid (Fmoc-MePhe(2-Cl)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa094-b (4.2 g, 82%) was obtained by the same method as in the synthesis of Compound aa078-b using Compound aa094-a ((2S)-3-(2-chlorophenyl)-2-[9H-fluoren-9-ylmethoxycarbonylamino]propanoic acid, Fmoc-Phe(2-Cl)—OH) (5 g, 11.85 mmol) as a starting material. 
     LCMS (ESI) m/z=434 (M+H)+ 
     Retention time: 1.01 min (analysis condition SQDFA05) 
     Compound aa094 ((2S)-3-(2-chlorophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-MePhe(2-Cl)—OH) (3.32 g, 79%) was obtained by the same method as in the synthesis of Compound aa078 using the obtained Compound aa094-b (4.2 g). 
     LCMS (ESI) m/z=436 (M+H)+ 
     Retention time: 0.94 min (analysis condition SQDFA05) 
     Synthesis of Compound aa095, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(2-fluorophenyl)propanoic acid (Fmoc-MePhe(2-F)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa095-b (3.21 g, quant.) was obtained by the same method as in the synthesis of Compound aa079-b using Compound aa095-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-(2-fluorophenyl)propanoic acid, Fmoc-Phe(2-F)—OH) (3 g, 7.4 mmol) as a starting material. 
     LCMS (ESI) m/z=418 (M+H)+ 
     Retention time: 0.97 min (analysis condition SQDFA05) 
     Compound aa095 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(2-fluorophenyl)propanoic acid, Fmoc-MePhe(2-F)—OH) (2.89 g, 96%) was obtained by the same method as in the synthesis of Compound aa079 using the obtained Compound aa095-b (3 g, 7.19 mmol). 
     LCMS (ESI) m/z=420 (M+H)+ 
     Retention time: 0.90 min (analysis condition SQDFA05) 
     Synthesis of Compound aa096, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(4-iodophenyl)propanoic acid (Fmoc-MePhe(4-I)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa096-b was obtained as a crude product (2.62 g) by the same method as in the synthesis of Compound aa078-b using Compound aa096-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-(4-iodophenyl)propanoic acid, Fmoc-Phe(4-I)—OH) (2.36 g, 4.6 mmol) as a starting material. 
     LCMS (ESI) m/z=526 (M+H)+ 
     Retention time: 1.07 min (analysis condition SQDFA05) 
     Compound aa096 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(4-iodophenyl)propanoic acid, Fmoc-MePhe(4-I)—OH) (2.36 g, 97%) was obtained by the same method as in the synthesis of Compound aa078 using the obtained Compound aa096-b (2.62 g). 
     LCMS (ESI) m/z=528 (M+H)+ 
     Retention time: 0.98 min (analysis condition SQDFA05) 
     Synthesis of Compound aa097, (2S)-3-(3-bromophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid (Fmoc-MePhe(3-Br)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa097-b was obtained as a crude product (2.98 g) by the same method as in the synthesis of Compound aa078-b using Compound aa097-a ((2S)-3-(3-bromophenyl)-2-[9H-fluoren-9-ylmethoxycarbonylamino]propanoic acid, Fmoc-Phe(3-Br)—OH) (3 g, 6.43 mmol) as a starting material. 
     LCMS (ESI) m/z=478 (M+H)+ 
     Retention time: 1.05 min (analysis condition SQDFA05) 
     Compound aa097 ((2S)-3-(3-bromophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-MePhe(3-Br)—OH) (2.87 g, 92% through two steps) was obtained by the same method as in the synthesis of Compound aa078 using the obtained Compound aa097-b (2.98 g). 
     LCMS (ESI) m/z=480 (M+H)+ 
     Retention time: 0.96 min (analysis condition SQDFA05) 
     Synthesis of Compound aa098, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-2-methyl-3-phenylpropanoic acid (Fmoc-Me(Me)Phe-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa098-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-2-methyl-3-phenylpropanoic acid (Fmoc-(Me)Phe-OH)) (2 g, 4.98 mmol) was suspended in toluene (16.61 mL), paraformaldehyde (0.449 g, 14.95 mmol) and (1S)-(+)-10-camphorsulfonic acid (0.058 g, 0.249 mmol) were added thereto, and the mixture was then stirred at 85° C. for four hours. The reaction solution was cooled to room temperature and then diluted with ethyl acetate. The organic layer was washed with a 5% aqueous sodium carbonate solution and an 18% aqueous sodium chloride solution, then dried over anhydrous sodium sulfate, filtered, and then concentrated under reduced pressure to give Compound aa098-b (2.07 g, 100%). 
     LCMS (ESI) m/z=414 (M+H)+ 
     Retention time: 1.01 min (analysis condition SQDFA05) 
     Compound aa098-b (520 mg, 1.258 mmol) was dissolved in dichloromethane (6.3 mL), triethylsilane (1.202 mL, 7.55 mmol) and a 1 M solution of titanium tetrachloride in dichloromethane (2.515 mL) were added, after which the mixture was stirred at 0° C. for one hour and then stirred at room temperature for one hour. To the reaction solution was added water, the mixture was filtered by a phase separator, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (0.1% formic acid-water/0.1% formic acid-acetonitrile) to give Compound aa098 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-2-methyl-3-phenylpropanoic acid, Fmoc-Me(Me)Phe-OH) (357 mg, 68%). 
     LCMS (ESI) m/z=416 (M+H)+ 
     Retention time: 0.91 min (analysis condition SQDFA05) 
     Synthesis of Compound aa101, (2S,4S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-(oxan-2-yloxy)pyrrolidine-2-carboxylic acid (Fmoc-cisHyp(THP)-OH) 
     
       
         
         
             
             
         
       
     
     To a solution of Compound aa101-a ((2S,4S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid, Fmoc-cisHyp-OH) (4.18 g, 11.83 mmol) in dichloromethane (42 mL) were added 3,4-dihydropyran (2.24 g, 2.25 equivalents) and PPTS (0.3 g, 0.1 equivalents), and the mixture was stirred at room temperature for 12 hours. Water was added to the reaction solution, which was then extracted with dichloromethane. The resulting organic layer was washed with water and brine. The solvent was evaporated under reduced pressure and the resulting residue was dissolved in THF (35 mL), after which 1.0 M phosphate buffer (pH=8.0, 35 mL) was added and the mixture was stirred at 50° C. for 4 hours and 30 minutes. To the reaction solution was added ethyl acetate (35 mL), after which the organic layer and the aqueous layer were separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, and filtered, and the solvent was then evaporated under reduced pressure. The resulting residue was dissolved in diethyl ether (50 mL), heptane (50 mL) was added, and the diethyl ether was evaporated under reduced pressure. The resulting solid was filtered to give Compound aa101 sodium salt (4.97 g). The obtained Compound aa101 sodium salt was dissolved in ethyl acetate (90 mL), a 0.05 M aqueous phosphoric acid solution (pH 2.1, 150 mL) was then added, and the mixture was stirred at room temperature for five minutes. The organic layer and the aqueous layer were separated, the aqueous layer was then extracted with ethyl acetate (90 mL), and the combined organic layers were washed with brine twice and dried over sodium sulfate. The resulting organic layer was filtered, and the solvent was then evaporated under reduced pressure to give Compound aa101 ((2S,4S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-(oxan-2-yloxy)pyrrolidine-2-carboxylic acid, Fmoc-cisHyp(THP)-OH) (4.57 g, yield: 80%). 
     LCMS (ESI) m/z=460 (M+Na)+ 
     Retention time: 0.81 min (analysis condition SQDFA05) 
     Synthesis of Compound aa102, (2S,4R)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-(oxan-2-yloxy)pyrrolidine-2-carboxylic acid (Fmoc-Hyp(THP)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa102 ((2S,4R)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-(oxan-2-yloxy)pyrrolidine-2-carboxylic acid, Fmoc-Hyp(THP)-OH) (5.15 g, 83%) was obtained by the same method as in the synthesis of Compound aa101 using Compound aa102-a ((2S,4R)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid, Fmoc-Hyp-OH) (5 g, 14.15 mmol) as a starting material. 
     LCMS (ESI) m/z=438 (M+H)+ 
     Retention time: 0.85 min (analysis condition SQDFA05) 
     Synthesis of Compound aa104, (2S)-3-(3-chloro-5-iodophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (Fmoc-Phe(3-I-5-Cl)—OH) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Compound aa104-a (methyl (2S)-3-(3-chlorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate) (1.05 g, 3.35 mmol) was dissolved in tert-butyl methyl ether (16.73 ml), bis(pinacolato)diboron (2.55 g, 10.04 mmol), (1,5-cyclooctadiene)(methoxy)iridium(I) dimer (0.111 g, 0.167 mmol), and 4,4′-di-tert-butyl-2,2′-bipyridine (0.090 g, 0.335 mmol) were added, and the mixture was stirred at room temperature overnight. The solvent was evaporated from the reaction solution under reduced pressure, and the resulting residue was purified by reverse phase chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa104-b (0.920 g, 63%). 
     Retention time: 1.06 min (analysis condition SQDFA05) 
       1 H-NMR (varian ascend 400, 400 MHz, CDCl 3 ) δ 7.65-7.61 (m, 1H), 7.43 (bs, 1H), 7.21-7.20 (m, 1H), 5.01-4.98 (m, 1H), 4.55-4.54 (m, 1H), 3.74-3.73 (m, 3H), 3.14-3.10 (m, 1H), 3.02-2.97 (m, 1H), 1.43-1.41 (m, 12H), 1.34 (s, 9H) 
     Compound aa104-b (0.900 g, 2.047 mmol) was dissolved in a mixed solution of methanol (18.61 ml) and water (1.861 ml), copper(I) iodide (0.585 g, 3.07 mmol) and N-iodosuccinimide (0.691 g, 3.07 mmol) were added, and the mixture was stirred at 80° C. for two hours. The reaction solution was cooled to room temperature and then filtered through celite, and the solvent was evaporated from the resulting filtrate under reduced pressure. The concentrated residue was purified by reverse phase chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa104-c (0.703 g, 78%). 
     LCMS (ESI) m/z=439.9 (M+H)+ 
     Retention time: 0.98 min (analysis condition SQDFA05) 
     Calcium chloride (2.65 g, 23.88 mmol) was suspended in water (6.63 ml), lithium hydroxide monohydrate (0.267 g, 6.37 mmol) was added, and the mixture was stirred for five minutes. Isopropanol (26.5 ml), and a solution of Compound aa104-c (0.700 g, 1.592 mmol) in tetrahydrofuran (6.63 ml) were sequentially added, and the mixture was stirred at room temperature for four hours. A 20% aqueous formic acid solution was added until the pH of the reaction solution became about 3, and the reaction solution was extracted with tert-butyl methyl ether. The organic layer was washed with a saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give Compound aa104-d (679 mg, 1.595 mmol). This was mixed with another lot synthesized in the same manner, and the next reaction was performed. 
     LCMS (ESI) m/z=424 (M−H)− 
     Retention time: 0.86 min (analysis condition SQDFA05) 
     Compound aa104-d (1.09 g, 2.56 mmol) was dissolved in TFE (12.8 mL), TMSCl (0.485 mL, 3.84 mmol) was added, and the mixture was stirred at room temperature for one hour. The solvent was evaporated from the reaction solution under reduced pressure to give Compound aa104-e as a crude product (997 mg). 
     LCMS (ESI) m/z=326 (M+H)+ 
     Retention time: 0.43 min (analysis condition SQDFA05) 
     Compound aa104-e (925 mg, 2.56 mmol) was suspended in water (10 ml), after which diisopropylethylamine (2.003 ml, 11.50 mmol), 1,4-dioxane (13.33 ml), and N-(9-fluorenylmethoxycarbonyloxy)succinimide (862 mg, 2.56 mmol) were sequentially added and the mixture was stirred at room temperature for one hour. To the reaction solution was added a 20% aqueous formic acid solution, and the 1,4-dioxane was evaporated under reduced pressure. Ethyl acetate was added to the concentrate, and the organic layer was extracted. The organic layer was washed with a saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was suspended in tert-butyl methyl ether/n-hexane (1/1) and separated by filtration to give Compound aa104 ((2S)-3-(3-chloro-5-iodophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Phe(3-I-5-Cl)—OH) (970 mg, 69%). 
     LCMS (ESI) m/z=570 (M+Na)+ 
     Retention time: 0.99 min (analysis condition SQDFA05) 
     Synthesis of Compound aa105, (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-fluoro-3-iodophenyl)propanoic acid (Fmoc-Phe(2-F-3-I)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa105-a ((2S)-3-(3-bromo-2-fluorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Phe(2-F-3-Br)—OH) (0.7 g, 1.445 mmol) was dissolved in 1,4-dioxane (14.5 mL), bis(pinacolato)diboron (1.468 g, 5.78 mmol), potassium acetate (0.397 g, 4.05 mmol), and [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.212 g, 0.289 mmol) were added at room temperature, and the mixture was stirred at 80° C. for 5.5 hours. After 5.5 hours, bis(pinacolato)diboron (0.147 g, 0.578 mmol), potassium acetate (0.040 g, 0.405 mmol), and [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.021 g, 0.029 mmol) were further added at room temperature, and the mixture was stirred at 80° C. for 1.5 hours. The reaction solution was filtered through celite, after which the mother liquor was concentrated under reduced pressure and the 1,4-dioxane was evaporated to give Compound aa105-b as a crude product. This was mixed with two lots synthesized in the same manner and was used for the next reaction. 
     The obtained Compound aa105-b (1.15 g, 2.17 mmol) was dissolved in a mixed solvent of methanol (9.75 mL) and water (1.08 mL), potassium acetate (0.425 g, 4.34 mmol), copper(I) iodide (1.16 g, 6.07 mmol), and N-iodosuccinimide (3.41 g, 15.17 mmol) were added at 0° C., and the mixture was stirred at 80° C. for two hours. Another reaction on the same scale was performed, two batches of the reaction solution were mixed and concentrated under reduced pressure to evaporate the methanol. The resulting residue was dissolved in ethyl acetate (80 mL), washed with a 7.7 to 8.3% aqueous ammonia solution (40 mL) three times, washed with a 1 M aqueous phosphoric acid solution (40 mL), and washed with a saturated sodium chloride aqueous solution (40 mL). The organic layer was dried over anhydrous sodium sulfate, filtered, and then concentrated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa105 ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-fluoro-3-iodophenyl)propanoic acid, Fmoc-Phe(2-F-3-I)—OH) (1.55 g, 88%). 
     LCMS (ESI) m/z=530 (M−H)− 
     Retention time: 0.90 min (analysis condition SQDFA05) 
     Synthesis of Compound aa106, (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3-fluoro-5-iodophenyl)propanoic acid Fmoc-Phe(3-I-5-F)—OH 
     
       
         
         
             
             
         
       
     
     Compound aa106-b was obtained as a crude product by the same method as in the synthesis of Compound aa105-b using Compound aa106-a ((2S)-3-(3-bromo-5-fluorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Phe(3-Br-5-F)—OH) (2.1 g, 4.335 mmol) as a starting material. 
     Compound aa106 ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3-fluoro-5-iodophenyl)propanoic acid, Fmoc-Phe(3-I-5-F)—OH) (1.54 g, 67%) was obtained by the same method as in the synthesis of Compound aa105 using Compound aa106-b (1.152 g, 2.17 mmol). 
     LCMS (ESI) m/z=530 (M−H)− 
     Retention time: 0.97 min (analysis condition SQDFA05) 
     Synthesis of Compound aa109, (2S)-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]propanoic acid (Fmoc-EtAla-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa109-a ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Ala-OH) (30 g, 96 mmol) was dissolved in toluene (321 mL), paraldehyde (19.10 mL, 145 mmol) and CSA (2.24 g, 9.64 mmol) were added, and the mixture was stirred at 80° C. for three hours. The reaction solution was cooled to room temperature, n-hexane (300 mL) and ethyl acetate (600 mL) were added, and the organic layer was washed with a saturated aqueous sodium bicarbonate solution and brine and dried over anhydrous sodium sulfate, after which the solvent was evaporated under reduced pressure. The resulting concentrate was dissolved in 20% ethyl acetate-hexane (400 mL) again, washed with a saturated aqueous sodium bicarbonate solution and brine, and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to give Compound aa109-b (22.07 g, 68%) as a crude product. 
     LCMS (ESI) m/z=338 (M+H)+ 
     Retention time: 0.90 min (analysis condition SQDFA05) 
     The obtained Compound aa109-b (22.04 g, 65.3 mmol) was dissolved in DCM (218 mL), TFA (150 mL, 1960 mmol) and triethylsilane (104 mL, 653 mmol) were added, and the mixture was stirred at room temperature for two hours. After concentration under reduced pressure, the concentrate was dissolved in DCM. The solution was concentrated under reduced pressure to a volume of about 200 mL, hexane (500 mL) was added, resulting in precipitation of the target compound. The target compound was collected by filtration to give Compound aa109 ((2S)-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]propanoic acid, Fmoc-EtAla-OH) (13.41 g, 61%). 
     LCMS (ESI) m/z=340 (M+H)+ 
     Retention time: 0.81 min (analysis condition SQDFA05) 
     Synthesis of Compound aa110, (2S)-3-(4-chlorophenyl)-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]propanoic acid (Fmoc-EtPhe(4-Cl)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa110-a ((2S)-3-(4-chlorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Phe(4-Cl)—OH) (3.00 g, 7.11 mmol) was dissolved in toluene (17.8 mL), paraldehyde (0.940 mL, 7.11 mmol) and CSA (0.165 g, 0.711 mmol) were added, and the mixture was stirred at 80° C. overnight. The reaction solution was cooled to room temperature, dissolved in 20% ethyl acetate-hexane (300 mL), washed twice with a saturated aqueous sodium bicarbonate solution and once with brine, and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to give Compound aa110-b (2.63 g, 83%) as a crude product. 
     LCMS (ESI) m/z=448 (M+H)+ 
     Retention time: 1.06 min (analysis condition SQDFA05) 
     The obtained Compound aa110-b (2.6 g, 5.8 mmol) was dissolved in DCE (19.35 mL), TFA (13.33 mL, 174 mmol) and triethylsilane (9.25 mL, 58.0 mmol) were added, and the mixture was stirred at 60° C. for six hours and then stirred at room temperature overnight. The crude product obtained by concentration under reduced pressure was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa110 ((2S)-3-(4-chlorophenyl)-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]propanoic acid, Fmoc-EtPhe(4-Cl)—OH) (1.46 g, 56%). 
     LCMS (ESI) m/z=450 (M+H)+ 
     Retention time: 0.98 min (analysis condition SQDFA05) 
     Synthesis of Compound aa111, (2S)-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-4-methylpentanoic acid (Fmoc-EtLeu-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa111-a ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid, Fmoc-Leu-OH) (4.95 g, 14.0 mmol, CAS No. 35661-60-0) was suspended in DCE (17.5 mL) under a nitrogen atmosphere, paraldehyde (5.61 mL, 42.0 mmol) and TFA (9.65 mL, 126 mmol) were added, and the mixture was stirred at 50° C. for six hours. The reaction mixture was cooled to room temperature and concentrated under reduced pressure, and the resulting residue was then dissolved in ethyl acetate (40 mL). The organic layer was washed with a saturated aqueous sodium bicarbonate solution (40 mL) and brine (40 mL) and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give Compound aa111-b as a crude product. 
     LCMS (ESI) m/z=380 (M+H)+ 
     Retention time: 1.02 min (analysis condition SQDFA05) 
     The total amount of Compound aa111-b obtained above was dissolved in DCE (35 mL), TFA (28.9 mL, 378 mmol) and triethylsilane (20.1 mL, 126 mmol) were added, and the mixture was stirred at 60° C. for 90 minutes. The reaction solution was cooled to room temperature, concentrated under reduced pressure, and then azeotropically distilled with toluene three times. The resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa111 ((2S)-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-4-methylpentanoic acid, Fmoc-EtLeu-OH) (3.15 g, 59% through two steps). 
     LCMS (ESI) m/z=382 (M+H)+ 
     Retention time: 0.94 min (analysis condition SQDFA05) 
     Synthesis of Compound aa112, (2S)-3-cyclohexyl-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]propanoic acid (Fmoc-EtCha-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa112-b was obtained as a crude product by the same method as in the synthesis of Compound aa111-b using Compound aa112-a ((2S)-3-cyclohexyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Cha-OH) (5.51 g, 14.0 mmol, CAS No. 135673-97-1) as a starting material. 
     LCMS (ESI) m/z=420 (M+H)+ 
     Retention time: 1.12 min (analysis condition SQDFA05) 
     Compound aa112 ((2S)-3-cyclohexyl-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]propanoic acid, Fmoc-EtCha-OH) (4.78 g, 81% through two steps) was obtained by the same method as in the synthesis of Compound aa111 using the total amount of Compound aa112-b obtained above. 
     LCMS (ESI) m/z=422 (M+H)+ 
     Retention time: 1.04 min (analysis condition SQDFA05) 
     Synthesis of Compound aa113, (2S)-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-(4-methylphenyl)propanoic acid (Fmoc-EtPhe(4-Me)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa113-a ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-methylphenyl)propanoic acid, Fmoc-Phe(4-Me)-OH) (5.62 g, 14.0 mmol, CAS No. 199006-54-7) was suspended in dichloroethane (DCE) (17.5 mL) under a nitrogen atmosphere, paraldehyde (5.61 mL, 42.0 mmol) and trifluoroacetic acid (TFA) (9.65 mL, 126 mmol) were added, and the mixture was stirred at 60° C. for six hours. The resulting reaction solution containing Compound aa113-b was used as such for the next step. 
     LCMS (ESI) m/z=428 (M+H)+ 
     Retention time: 1.03 min (analysis condition SQDFA05) 
     To the resulting reaction solution of Compound aa113-b were added dichloroethane (DCE) (17.5 mL), trifluoroacetic acid (TFA) (19.3 mL, 252 mmol), and triethylsilane (TES) (20.1 mL, 126 mmol), and the mixture was stirred at 60° C. for 17 hours. The reaction mixture was cooled to room temperature and concentrated under reduced pressure, and the resulting residue was then dissolved in ethyl acetate (40 mL). The organic layer was washed with a saturated aqueous sodium bicarbonate solution (40 mL) and brine (40 mL) and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was dissolved in acetonitrile (30 mL) and washed with hexane (15 mL) twice, and the solvent was evaporated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa113 ((2S)-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-(4-methylphenyl)propanoic acid, Fmoc-EtPhe(4-Me)-OH) (4.4 g, 73% through two steps). 
     LCMS (ESI) m/z=430 (M+H)+ 
     Retention time: 0.95 min (analysis condition SQDFA05) 
     Synthesis of Compound aa114, (2S)-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]propanoic acid (Fmoc-EtPhe(4-CF3)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa114-a ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[4-(trifluoromethyl)phenyl]propanoic acid, Fmoc-Phe(4-CF3)-OH) (4.04 g, 8.87 mmol, CAS No. 247113-86-6) was suspended in DCE (11.1 mL) under a nitrogen atmosphere, anhydrous magnesium sulfate (4.27 g, 35.4 mmol), paraldehyde (3.55 mL, 26.6 mmol), and trifluoroacetic acid (TFA) (6.11 mL, 80 mmol) were added, and the mixture was stirred at 60° C. for three hours. Anhydrous magnesium sulfate (2.14 g, 17.7 mmol) was further added and the mixture was stirred at 60° C. for one hour. The resulting reaction solution containing Compound aa114-b was used as such for the next reaction. 
     LCMS (ESI) m/z=482 (M+H)+ 
     Retention time: 1.04 min (analysis condition SQDFA05) 
     To the resulting reaction solution containing Compound aa114-b were added DCE (11.1 mL), TFA (12.2 mL, 159 mmol), and triethylsilane (12.7 mL, 80 mmol), and the mixture was stirred at 60° C. for 10 hours. The reaction solution was cooled to room temperature, the magnesium sulfate was filtered off, and the filtrate was then concentrated under reduced pressure. Because the intended reaction was not completed, the resulting residue was dissolved in DCE (22.2 mL), TFA (18.3 mL, 239 mmol) and triethylsilane (12.7 mL, 80 mmol) were added, and the mixture was stirred at 60° C. for eight hours. The reaction mixture was cooled to room temperature and concentrated under reduced pressure, and the resulting residue was then dissolved in ethyl acetate (40 mL). The organic layer was washed with a saturated aqueous sodium bicarbonate solution (40 mL) and brine (40 mL) and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was dissolved in acetonitrile (30 mL) and washed with hexane (15 mL) twice, and the solvent was evaporated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (water-acetonitrile, containing 0.1% formic acid) to give Compound aa114 ((2S)-2-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]propanoic acid, Fmoc-EtPhe(4-CF3)-OH) (1.90 g, 44% through two steps). 
     LCMS (ESI) m/z=484 (M+H)+ 
     Retention time: 0.97 min (analysis condition SQDFA05) 
     Synthesis of Compound aa116, (2S)-3-(2,6-difluorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (Fmoc-Phe(26-F2)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa116-a ((2S)-2-amino-3-(2,6-difluorophenyl)propanoic acid, H-Phe(26-F2)-OH) (1.00 g, 4.97 mmol) was dissolved in a mixed solvent of 1,4-dioxane (12 mL) and distilled water (9 mL), diisopropylethylamine (DIPEA) (3.03 ml, 17.4 mmol) and N-(9-fluorenylmethoxycarbonyloxy)succinimide (Fmoc-OSu) (1.761 g, 5.22 mmol) were added, and the mixture was stirred at room temperature for one hour. To the reaction solution were added a 20% aqueous formic acid solution and dimethyl sulfoxide, after which the mixture was concentrated under reduced pressure and the 1,4-dioxane was evaporated. The resulting concentrate was purified by reverse phase chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa116 ((2S)-3-(2,6-difluorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Phe(26-F2)-OH) (1.81 g, 86%). 
     LCMS (ESI) m/z=445.9 (M+Na)+ 
     Retention time: 1.202 min (analysis condition SMDmethod_04) 
     Synthesis of Compound aa118, (2S)-3-(2,5-difluorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (Fmoc-Phe(25-F2)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa118 ((2S)-3-(2,5-difluorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Phe(25-F2)-OH) (2.43 g, 58%) was obtained by the same method as in the synthesis of Compound aa116 using Compound aa118-a ((2S)-2-amino-3-(2,5-difluorophenyl) propanoic acid, H-Phe(25-F2)-OH)(2 g, 9.94 mmol) as a starting material. 
     LCMS (ESI) m/z=424 (M+H)+ 
     Retention time: 0.85 min (analysis condition SQDFA05) 
     Synthesis of Compound aa119, (2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-(3-iodophenyl)-2-methylpropanoic acid (Fmoc-(Me)Phe(3-I)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa119 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-3-(3-iodophenyl)-2-methylpropanoic acid, Fmoc-(Me)Phe(3-I)—OH) (1.1 g, 64%) was obtained by the same method as in the synthesis of Compound aa116 using Compound aa119-a ((2S)-2-amino-3-(3-iodophenyl)-2-methylpropanoic acid, H-(Me)Phe(3-T)-OH) (1 g, 3.28 mmol) as a starting material. 
     LCMS (ESI) m/z=528 (M+H)+ 
     Retention time: 0.98 minute (analysis condition SQDFA05) 
     Synthesis of Compound aa120, (2S)-3-(3,5-dichlorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (Fmoc-Phe(35-Cl2)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa120 ((2S)-3-(3,5-dichlorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Phe(35-Cl2)-OH) (6.2 g, 80%) was obtained by the same method as in the synthesis of Compound aa116 using Compound aa120-a ((2S)-2-amino-3-(3,5-dichlorophenyl)propanoic acid, H-Phe(35-Cl2)-OH) (4 g, 17.09 mmol) as a starting material and using sodium carbonate instead of DIPEA. 
     LCMS (ESI) m/z=456 (M+H)+ 
     Retention time: 0.94 min (analysis condition SQDFA05) 
     Synthesis of Compound aa121, (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-fluoro-5-iodophenyl)propanoic acid (Fmoc-Phe(2-F-5-I)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa121 ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-fluoro-5-iodophenyl)propanoic acid, Fmoc-Phe(2-F-5-I)—OH) (1.6 g, 92%) by the same method as in the synthesis of Compound aa116 using Compound aa121-a ((2S)-2-amino-3-(2-fluoro-5-iodophenyl)propanoic acid, H-Phe(2-F-5-I)—OH) (1 g, 3.24 mmol) as a starting material. 
     LCMS (ESI) m/z=532 (M+H)+ 
     Retention time: 0.94 min (analysis condition SQDFA05) 
     Synthesis of Compound aa122, (2S)-3-(2-chloro-5-iodophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (Fmoc-Phe(2-Cl-5-I)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa122 ((2S)-3-(2-chloro-5-iodophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Phe(2-Cl-5-I)—OH) (0.93 g, 55%) was obtained by the same method as in the synthesis of Compound aa116 using Compound aa122-a ((2S)-2-amino-3-(2-chloro-5-iodophenyl)propanoic acid, H-Phe(2-Cl-5-I)—OH) (1 g, 3.07 mmol) as a starting material. 
     LCMS (ESI) m/z=546 (M−H)− 
     Retention time: 0.97 min (analysis condition SQDFA05) 
     Synthesis of Compound aa124, (2S)-3-(5-chlorothiophen-2-yl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (Fmoc-Ala(2-Thie-5-Cl)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa124 ((2S)-3-(5-chlorothiophen-2-yl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Ala(2-Thie-5-Cl)—OH) (0.87 g, 84%) was obtained by the same method as in the synthesis of Compound aa116 using Compound aa124-a ((2S)-2-amino-3-(5-chlorothiophen-2-yl)propanoic acid, H-Ala(2-Thie-5-Cl)—OH) (0.5 g, 2.431 mmol) as a starting material. 
     LCMS (ESI) m/z=426 (M−H)− 
     Retention time: 0.91 min (analysis condition SQDFA05) 
     Synthesis of Compound aa125, (2S)-3-(5-bromothiophen-2-yl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (Fmoc-Ala(2-Thie-5-Br)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa125 ((2S)-3-(5-bromothiophen-2-yl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Ala (2-Thie-5-Br)—OH) (0.80 g, 85%) was obtained by the same method as in the synthesis of Compound aa116 using Compound aa125-a ((2S)-2-amino-3-(5-bromothiophen-2-yl)propanoic acid, H-Ala(2-Thie-5-Br)—OH) (0.5 g, 2 mmol) as a starting material. 
     LCMS (ESI) m/z=470 (M−H)− 
     Retention time: 0.91 min (analysis condition SQDFA05) 
     Synthesis of Compound aa126, (2S)-3-(2-bromo-5-iodophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (Fmoc-Phe(2-Br-5-I)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa126 ((2S)-3-(2-bromo-5-iodophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Phe(2-Br-5-I)—OH) (0.80 g, 25%) was obtained by the same method as in the synthesis of Compound aa116 using Compound aa126-a ((2S)-2-amino-3-(2-bromo-5-iodophenyl)propanoic acid, H-Phe(2-Br-5-I)—OH) (2 g, 5.41 mmol) as a starting material. 
     LCMS (ESI) m/z=590 (M−H)− 
     Retention time: 0.96 min (analysis condition SQDFA05) 
     Synthesis of Compound aa127, (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(5-iodo-2-methylphenyl)propanoic acid (Fmoc-Phe(2-Me-5-I)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa127 ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(5-iodo-2-methylphenyl)propanoic acid, Fmoc-Phe(2-Me-5-I)—OH) (2.87 g, quant.) was obtained by the same method as in the synthesis of Compound aa116 using Compound aa127-a ((2S)-2-amino-3-(5-iodo-2-methylphenyl)propanoic acid, H-Phe(2-Me-5-I)—OH) (1.651 g, 5.41 mmol) as a starting material. 
     LCMS (ESI) m/z=526 (M−H)− 
     Retention time: 0.97 min (analysis condition SQDFA05) 
     Synthesis of Compound aa128, (2S)-3-(5-bromo-2-methylphenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (Fmoc-Phe(2-Me-5-Br)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa128 ((2S)-3-(5-bromo-2-methylphenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid, Fmoc-Phe(2-Me-5-Br)—OH) (2.91 g, quant.) was obtained by the same method as in the synthesis of Compound aa116 using Compound aa128-a ((2S)-2-amino-3-(5-bromo-2-methylphenyl)propanoic acid, H-Phe(2-Me-5-Br)—OH) (1.396 g, 5.41 mmol) as a starting material. 
     LCMS (ESI) m/z=478 (M−H)− 
     Retention time: 0.96 min (analysis condition SQDFA05) 
     Synthesis of Compound aa130, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]octanoic acid (Fmoc-MeAOC(2)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa130-b was obtained as a crude product by the same method as in the synthesis of Compound aa069-b using Compound aa130-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]octanoic acid, Fmoc-AOC(2)-OH) (6.15 g, 16.12 mmol) as a starting material. Further, Compound aa130 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]octanoic acid, Fmoc-MeAOC(2)-OH) (6.4 g, 100% through two steps) was obtained by the same method as in the synthesis of Compound aa069 using Compound aa130-b. 
     LCMS (ESI) m/z=396.3 (M+H)+ 
     Retention time: 1.00 min (analysis condition SQDFA05) 
     Synthesis of Compound aa131, (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-5-methylhexanoic acid (Fmoc-MeHle-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa131-b was obtained as a crude product by the same method as in the synthesis of Compound aa078-b using Compound aa131-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonylamino]-5-methylhexanoic acid, Fmoc-Hle-OH) (20 g, 54.4 mmol) as a starting material. Further, Compound aa131 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-5-methylhexanoic acid, Fmoc-MeHle-OH) (21.5 g, quant.) was obtained by the same method as in the synthesis of Compound aa078 using Compound aa131-b. 
     LCMS (ESI) m/z=382 (M+H)+ 
     Retention time: 0.95 min (analysis condition SQDFA05) 
     Synthesis of Compound aa132, (2S)-4-[3-chloro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid, Fmoc-Hph(4-CF3-3-Cl)—OH 
     
       
         
         
             
             
         
       
     
     To a solution of (4S)-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxo-5-phenylmethoxypentanoic acid (Boc-Glu-OBn, CAS No. 30924-93-7) (200 g, 592.82 mmol), N-hydroxyphthalimide (106 g, 649.78 mmol, 1.10 equivalents), and DMAP (3.6 g, 29.47 mmol, 0.05 equivalents) in THF (2 L) was added dropwise DIC (138 mL, 1.54 equivalents) at 0° C. under a nitrogen atmosphere. The reaction solution was stirred at 25° C. for 16 hours, the solid was removed by filtration, and the solvent was evaporated from the filtrate under reduced pressure. The residue was diluted with toluene, the resulting solid was removed by filtration, and the solvent was evaporated from the filtrate under reduced pressure. The residue was purified by recrystallization (acetone/heptane) to give Compound aa132-a (1-O-benzyl 5-O-(1,3-dioxoisoindol-2-yl) (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate) (230 g, 80%). 
     LCMS (ESI) m/z=505.2 (M+Na)+ 
     Retention time: 0.992 min (analysis condition SMDmethod_16) 
     Nickel bromide trihydrate (NiBr 2 .3H 2 O) (4 g, 0.07 equivalents) and 4,4′-di-tert-butyl-2,2′-bipyridyl (dtbbpy, CAS No. 72914-19-3) (3.9 g, 14.55 mmol, 0.07 equivalents) were added to DMA (500 mL), and the mixture was stirred at 50° C. for two hours under a nitrogen atmosphere to prepare a Ni solution. 
     To a mixture of Compound aa132-a (100 g, 207.3 mmol), zinc powder (70 g, 5 equivalents), and 4-bromo-2-chloro-1-(trifluoromethyl)benzene (CAS No. 467435-07-0, 160 g, 617 mmol, 3 equivalents) in DMA (500 mL) was added the Ni solution prepared above, and the mixture was stirred at 25° C. for 16 hours. To the reaction solution was added an aqueous EDTA2Na solution (10%), and the mixture was extracted with ethyl acetate. The combined organic layers were washed with brine and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give Compound aa132-b (75 g, 77%). 
     LCMS (ESI) m/z=494 (M+Na)+ 
     Retention time: 2.863 min (analysis condition SMDmethod_17) 
     A solution of Compound aa132-b (75 g, 158.93 mmol) in toluene (900 mL) was cooled to 0° C., and trifluoromethanesulfonic acid (TfOH) (42 mL, 3.00 equivalents) was added dropwise. After stirring at room temperature for one hour, water (75 mL) was added. The mixture was extracted with water, and the combined aqueous layers were extracted with ethyl acetate. The combined organic layers were washed with water and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure. To the residue was added acetonitrile/water (900/900 mL), and the pH was adjusted to 7 with an aqueous sodium hydroxide solution (48%). To this solution was added Fmoc-OSu (51.2 g, 151.93 mmol, 0.95 equivalents), and the mixture was stirred at room temperature for 16 hours while maintaining the pH at 7.8-8.0. The reaction solution was filtered and the filtrate was adjusted to pH 2 with 6 mol/L aqueous hydrochloric acid. The precipitated solid was collected and dried at 50° C. to give Compound aa132 ((2S)-4-[3-chloro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid, Fmoc-Hph(4-CF3-3-Cl)—OH) (70 g, 87%). 
     LCMS (ESI) m/z=525.8 (M+Na)+ 
     Retention time: 2.180 min (analysis condition SMDmethod_21)  1 H-NMR (300 MHz, DMSO-d6) δ 12.70 (s, 1H), 7.91 (d, J=7.5 Hz, 2H), 7.79-7.59 (m, 5H), 7.45-7.28 (m, 5H), 4.40-4.19 (m, 3H), 3.96-3.88 (m, 1H), 2.82-2.60 (m, 2H), 2.11-1.77 (m, 2H) 
     Synthesis of Compound aa133, (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[3-fluoro-4-(trifluoromethyl)phenyl]butanoic acid (Fmoc-Hph(4-CF3-3-F)—OH) 
     
       
         
         
             
             
         
       
     
     Nickel bromide trihydrate (NiBr 23 H 2 O) (71.5 g, 263 mmol, 0.3 equivalents) and 4,4′-di-tert-butyl-2,2′-bipyridyl (dtbbpy, CAS No. 72914-19-3) (70.56 g, 263 mmol, 0.3 equivalents) were added to DMA (2 L), and the mixture was stirred at 50° C. for three hours under a nitrogen atmosphere to prepare a Ni solution. 
     A mixture of Compound aa039-a (1-O-tert-butyl 5-O-(1,3-dioxoisoindol-2-yl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioate) (500 g, 876 mmol), which was synthesized according to the method described in this example using compound Fmoc-Glu-OtBu ((4S)-4-(9H-fluorene-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid, CAS No. 84793-07-7) as a raw material, zinc powder (287 g, 4.38 mol, 5 equivalents), and 4-bromo-2-fluoro-1-(trifluoromethyl)benzene (CAS No. 142808-15-9, 425.87 g, 1.753 mol, 2 equivalents) in DMA (2 L) was stirred at room temperature for 1 hour under a nitrogen atmosphere. To this mixture was added the Ni solution prepared above, and the mixture was stirred at room temperature for 16 hours. To the reaction solution was added an aqueous EDTA-2Na solution (4 L, 10%), and the solid was removed by filtration while washing with ethyl acetate. The filtrate was washed with brine and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give Compound aa133-a (230 g, 43%). 
     LCMS (ESI) m/z=566.2 (M+Na)+ 
     Retention time: 1.317 min (analysis condition SMDmethod_18) 
     A mixture of the obtained Compound aa133-a (230 g, 423 mmol) and chlorotrimethylsilane (TMSCl) (137.9 g, 1.269 mol) in trifluoroethanol (TFE) (2.3 L) was stirred at room temperature for one hour, and the precipitated solid was collected by filtration. The resulting solid was dissolved in TBME and the solvent was evaporated under reduced pressure. This operation was repeated several times to give the target Compound aa133 ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[3-fluoro-4-(trifluoromethyl)phenyl]butanoic acid, Fmoc-Hph(4-CF3-3-F)—OH) (190 g, 90%). 
     LCMS (ESI) m/z=510.2 (M+Na)+ 
     Retention time: 1.585 min (analysis condition SMDmethod_13) 
       1 H-NMR (300 MHz, DMSO-d6) δ 12.69 (s, 1H), 7.90 (d, J=7.5 Hz, 2H), 7.81-7.66 (m, 4H), 7.47-7.37 (m, 3H), 7.37-7.29 (m, 2H), 7.25 (d, J=8.1 Hz, 1H), 4.44-4.14 (m, 3H), 3.97-3.84 (m, 1H), 2.80-2.63 (m, 2H), 2.12-1.81 (m, 2H). 
     Synthesis of Compound aa134, (2S)-4-[3,5-difluoro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid, Fmoc-Hph(4-CF3-35-F2)-OH 
     
       
         
         
             
             
         
       
     
     Nickel bromide trihydrate (NiBr 2 .3H 2 O) (13.5 g, 49.7 mmol, 0.3 equivalents) and 4,4′-di-tert-butyl-2,2′-bipyridyl (dtbbpy, CAS No. 72914-19-3) (13.3 g, 49.7 mmol, 0.3 equivalents) were added to DMA (400 mL), and the mixture was stirred at 50° C. for three hours under a nitrogen atmosphere to prepare a Ni solution. 
     A mixture of Compound aa132-a (1-O-benzyl 5-O-(1,3-dioxoisoindol-2-yl) (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate) (80 g, 166 mmol), zinc powder (54.2 g, 829 mmol, 5 equivalents), and 4-bromo-1,3-difluoro-2-(trifluoromethyl)benzene (CAS No. 156243-64-0, 86.6 g, 332 mmol, 2 equivalents) in DMA (400 mL) was stirred at room temperature for one hour under a nitrogen atmosphere. The above-prepared Ni solution was added, and the mixture was stirred at room temperature for 16 hours. To the reaction solution was added an aqueous EDTA-2Na solution (800 mL, 10%), and the solid was removed by filtration. The filtrate was extracted with ethyl acetate, the combined organic layers were washed with brine and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give Compound aa134-a (57.2 g, 69%). 
     LCMS (ESI) m/z=496 (M+Na)+ 
     Retention time: 1.544 min (analysis condition SMDmethod_15) 
     A mixture of Compound aa134-a (57.2 g, 121 mmol) in toluene (690 mL) was cooled to 0° C., and trifluoromethanesulfonic acid (TfOH) (54.4 g, 362 mmol, 3 equivalents) was added dropwise. After stirring at room temperature for one hour, water (58 mL) was added. The mixture was extracted with water, and the combined aqueous layers were extracted with ethyl acetate. The combined organic layers were washed with water and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to give 60 g of a residue. To the residue was added acetonitrile/water (400/400 mL), and the pH was adjusted to 7 with an aqueous sodium hydroxide solution (48%). To the solution was added Fmoc-OSu (36.6 g, 108.6 mmol, 0.9 equivalents), the pH was adjusted to 8.0 with an aqueous sodium hydroxide solution (48%), and the mixture was then stirred at room temperature for 16 hours. The reaction solution was filtered while washing with acetonitrile/water (1/1) to remove the solid component. The filtrate was diluted with acetonitrile and acidified with 6 mol/L aqueous hydrochloric acid, and the precipitated solid was collected by filtration to give Compound aa134 ((2S)-4-[3,5-difluoro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid, Fmoc-Hph(4-CF3-35-F2)-OH) (52 g, 83%). 
     LCMS (ESI) m/z=528.45 (M+Na)+ 
     Retention time: 3.538 min (analysis condition SMDmethod_14) 
     1H-NMR (300 MHz, DMSO-d6) δ 12.69 (s, 1H), 7.90 (d, J=7.5 Hz, 2H), 7.78-7.54 (m, 3H), 7.48-7.20 (m, 6H), 4.33 (d, J=6.3 Hz, 2H), 4.24 (t, J=6.9 Hz, 1H), 3.97-3.84 (m, 1H), 2.79-2.65 (m, 2H), 2.15-2.00 (m, 1H), 2.00-1.83 (m, 1H) 
     Synthesis of Compound aa150 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-5,5,5-trifluoropentanoic acid, Fmoc-MeNva(5-F2)-OH) 
     
       
         
         
             
             
         
       
     
     A mixture of Compound aa150-a ((2S)-2-(phenylmethoxycarbonylamino)pentanedioic acid) (50 g, 177.8 mmol), paraformaldehyde (11.87 g), and p-toluenesulfonic acid (1.84 g, 10.69 mmol) in toluene (500 mL) was stirred at 120° C. for 16 hours. The reaction solution was left to cool to room temperature, diluted with ethyl acetate, washed with brine, then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give Compound aa150-b as a crude product (52 g, 96%). The crude product was used for the next reaction without purification. 
     A solution of Compound aa150-b (4 g, 13.64 mmol) in thionyl chloride (50 mL) was stirred at 85° C. for one hour, and the solvent was then evaporated under reduced pressure. The residue was dissolved in THF (20 mL) and cooled to −78° C. under a nitrogen atmosphere. A solution of lithium tri-tert-butoxyaluminum hydride (2.76 g, 10.87 mmol) in THF (20 mL) was added thereto dropwise over 2.5 hours. After stirring at −78° C. for three hours, water was added to the reaction solution, and the precipitate was removed by filtration. The filtrate was extracted with ethyl acetate, the organic layer was washed with brine, then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give Compound aa150-c (2 g). 
       1 H-NMR (400 MHz, CDCl 3 ) δ 7.41-7.32 (m, 5H), 5.49 (br.s, 1H), 5.27-5.11 (m, 3H), 4.38-4.33 (m, 1H), 2.58-2.19 (m, 4H) 
     To a solution of Compound aa150-c (450 mg, 1.62 mmol) in DCM (20 mL) was added N,N-diethylaminosulfur trifluoride (DAST) (780 mg, 4.84 mmol) at 0° C. under a nitrogen atmosphere, and the mixture was stirred at room temperature for 16 hours. After adding water, the reaction solution was diluted with DCM and sequentially washed with an aqueous sodium bicarbonate solution and brine. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give Compound aa150-d (0.35 g, 72%). This was mixed with another lot synthesized in the same manner, and the next reaction was performed. 
       1 H-NMR (400 MHz, CDCl 3 ) δ 7.42-7.35 (m, 5H), 5.97-5.58 (m, 2H), 5.25-5.16 (m, 3H), 4.50-4.35 (m, 1H), 2.14-1.68 (m, 4H) 
       19 F-NMR (400 MHz, CDCl 3 ) δ-116.562 
     Compound aa150-d (1 g, 3.34 mmol) and TES (12.63 g, 109 mmol) were dissolved in TFA/DCM (10/10 mL), the mixture was stirred at room temperature for four days, and the solvent was then evaporated under reduced pressure. The residue was diluted with an aqueous sodium bicarbonate solution, washed with ether, and then adjusted to pH 3 with 2 N aqueous hydrochloric acid. The organic layer was extracted with DCM, washed with brine, and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give Compound aa150-e (0.6 g) as a crude product. The crude product was used for the next reaction without purification. 
     A mixture of Compound aa150-e (0.6 g) and palladium on carbon (10%, 60 mg) in methanol (10 mL) was stirred for 16 hours under a hydrogen atmosphere at about 3 atm. The palladium on carbon was removed by filtration, and the solvent was evaporated from the filtrate under reduced pressure to give Compound aa150-f (0.23 g) as a crude product. The crude product was used for the next reaction without purification. This was mixed with another lot synthesized in the same manner, and the next reaction was performed. 
     To a mixture of Compound aa150-f (0.3 g, 1.79 mmol) and potassium carbonate (745 mg, 5.4 mmol) in 1,4-dioxane/water (5/5 mL) was added Fmoc-OSu (0.9 g, 1.5 equivalents), and the mixture was stirred for two hours. The reaction solution was diluted with water, washed with diethyl ether, and then adjusted to pH 3 with 2 N aqueous hydrochloric acid. The organic layers were extracted with ethyl acetate three times, combined, washed with brine, and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.05% TFA/distilled water with 0.05% TFA) to give Compound aa150 ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-5,5,5-trifluoropentanoic acid, Fmoc-MeNva(5-F2)-OH) (0.2 g, 29%). Another lot synthesized in the same manner was also used for peptide synthesis in the present Examples. 
     Retention time: 3.153 min (analysis condition SMDmethod_19) 
       1 H-NMR (300 MHz, DMSO-d6) δ 12.94 (br.s, 1H), 7.92-7.88 (d, J=7.2 Hz, 2H), 7.66-7.61 (m, 2H), 7.44-7.31 (m, 4H), 6.35-5.75 (m, 1H), 4.49-4.26 (m, 4H), 2.72 (s, 3H), 1.78-1.65 (m, 4H) 
       19 F-NMR (300 MHz, DMSO-d6) δ-115.730 
     Synthesis of Compound aa151 ((2S)-3-(3,4-difluorophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid. Fmoc-MePhe(34-F2)-OH) 
     
       
         
         
             
             
         
       
     
     Compound aa151-b was obtained as a crude product by the same method as in the synthesis of Compound aa078-b using Compound aa151-a ((2S)-3-(3,4-difluorophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-Phe(34-F2)-OH) (105 mg, 0.247 mmol) as a starting material. Further, Compound aa151 ((2S)-3-(3,4-difluorophenyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, Fmoc-MePhe(34-F2)-OH) (74.4 mg, 69% through two steps) was obtained by the same method as in the synthesis of Compound aa060 using aa151-b. 
     LCMS (ESI) m/z=438 (M+H)+ 
     Retention time: 0.88 min (analysis condition SQDFA05) 
     Synthesis of Compound aa152 ((2S)-4-(4,4-difluoropiperidin-1-yl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid, Fmoc-MeAsn(pip-4-F2)-OH) 
     
       
         
         
             
             
         
       
     
     To a mixture of Compound aa033-a (9H-fluoren-9-ylmethyl (4S)-5-oxo-4-(2-oxo-2-prop-2-enoxyethyl)-1,3-oxazolidine-3-carboxylate) (10.3 g, 25.3 mmol) in DCM (25.3 mL) were added phenylsilane (2.176 ml, 17.7 mmol) and tetrakis(triphenylphosphine)palladium(0) (146 mg, 0.126 mmol), and the mixture was stirred at room temperature for 50 minutes. The reaction solution was diluted with TBME (10 v/w) and washed with a 5% aqueous sodium bicarbonate solution. The aqueous layer was adjusted to pH 4 with phosphoric acid and extracted with TBME. The resulting organic layer was washed with brine/water (1/1) and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to give Compound aa152-c (9.12 g, 98%). 
     LCMS (ESI) m/z=368 (M+H)+ 
     Retention time: 0.72 min (analysis condition SQDFA05) 
     Compound aa152-c (9.1 g, 24.77 mmol) and HOBt (3.68 g, 27.2 mmol) were added to a suspension of WSCI—HCl (5.7 g, 29.7 mmol) in DMF (70.8 mL) at 0° C., and the mixture was stirred at 0° C. for 30 minutes. 4,4-Difluoropiperidine hydrochloride (4.29 g, 27.2 mmol) and DIPEA (4.39 mL, 24.77 mL) were added thereto, and the mixture was stirred at 0° C. for one hour. The reaction solution was diluted with ethyl acetate and sequentially washed with 0.5 mol/L aqueous hydrochloric acid, water, saturated aqueous sodium bicarbonate/water (1/1), and brine/water (1/1). The resulting organic layer was dried over anhydrous sodium sulfate and the solvent was then evaporated under reduced pressure to give Compound aa152-d (10.87 g, 93%). 
     LCMS (ESI) m/z=471 (M+H)+ 
     Retention time: 0.85 min (analysis condition SQDFA05) 
     The obtained Compound aa152-d (10.87 g) was reacted by the same method as in the synthesis of Compound aa069 and then purified by reverse phase column chromatography (0.1% aqueous formic acid/0.1% formic acid-acetonitrile) to give Compound aa152, (2S)-4-(4,4-difluoropiperidin-1-yl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid (Fmoc-MeAsn(pip-4-F2)-OH) (10.6 g, 91%). 
     LCMS (ESI) m/z=473 (M+H)+ 
     Retention time: 0.78 min (analysis condition SQDFA05) 
     Synthesis of Compound aa153 ((2S)-4-(3,3-difluoroazetidin-1-yl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid, Fmoc-MeAsn(Aze-3-F2)-OH) 
     
       
         
         
             
             
         
       
     
     A suspension of Compound aa047-c ((2S)-4-(3,3-difluoroazetidin-1-yl)-2-[methyl(phenylmethoxycarbonyl)amino]-4-oxobutanoic acid) (500 mg, 1.403 mmol) and 10% palladium on carbon (50 w/w % water, 100 mg) in ethanol (15 mL) was stirred at room temperature for 13 hours and 15 minutes under a hydrogen atmosphere, after which the reaction mixture was filtered through celite, and the resulting filtrate was concentrated under reduced pressure to yield Compound aa153-a as a crude product (324 mg). 
     Compound aa153-a (324 mg) was dissolved in distilled water (5 ml), 1,4-dioxane (5 ml), diisopropylethylamine (DIPEA) (1.019 ml, 5.83 mmol), and N-(9-fluorenylmethoxycarbonyloxy)succinimide (Fmoc-OSu) (492 mg, 1.458 mmol) were added, and the mixture was stirred at room temperature for 30 minutes. To the reaction solution were added water (5 mL) and hexane/cyclopentyl methyl ether (3/1, 5 mL), and the mixture was washed with hexane/ether (3/1). To the resulting aqueous layer were added potassium hydrogen sulfate (0.79 g), ethyl acetate, and saturated aqueous potassium hydrogen sulfate (1 mL), and the mixture was extracted with ethyl acetate. The resulting organic layer was washed with brine/water (1/1) and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give Compound aa153, (2S)-4-(3,3-difluoroazetidin-1-yl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid (Fmoc-MeAsn(Aze-3-F2)-OH) (660 mg, quant.). 
     LCMS (ESI) m/z=445 (M+H)+ 
     Retention time: 0.72 min (analysis condition SQDFA05) 
     Synthesis of Compound aa154, ((2S)-2-(9H-fluoren-9-ylmethoxycarbonyl(methyl)amino)-3-(3-iodophenyl)propanoic acid, Fmoc-MePhe(3-I)—OH) 
     
       
         
         
             
             
         
       
     
     Compound aa154-b (3.11 g) was obtained as a crude product by the same method as in the synthesis of Compound aa078-b using Compound aa154-a ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3-iodophenyl)propanoic acid, Fmoc-Phe(3-I)—OH) (containing one molecule of THF per molecule of amino acid, 3.29 g, 5.62 mmol) as a starting material. 
     LCMS (ESI) m/z=526 (M+H)+ 
     Retention time: 1.07 min (analysis condition SQDFA05) 
     Compound aa154 ((2S)-2-(9H-fluoren-9-ylmethoxycarbonyl(methyl)amino)-3-(3-iodophenyl)propanoic acid (Fmoc-MePhe(3-I)—OH)) (2.924 g, 99% through two steps) was obtained by the same method as in the synthesis of Compound aa078 using the obtained Compound aa154-b. 
     LCMS (ESI) m/z=528 (M+H)+ 
     Retention time: 0.98 min (analysis condition SQDFA05) 
     The amino acid to be loaded on the resin was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Synthesis of Compound aa155-c, (2R)-3-(tert-butyldisulfanyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid 
     A mixture of (2R)-3-(tert-butyldisulfanyl)-2-[9H-fluoren-9-ylmethoxycarbonylamino]propanoic acid (20.0 g, 46.3 mmol), (+)-camphorsulfonic acid (752.6 mg, 3.2 mmol, 0.07 equivalents), and paraformaldehyde (13.9 g, 463.4 mmol, 10.0 equivalents) in toluene (200 mL) was stirred at room temperature for 1 hour under a nitrogen atmosphere. The reaction solution was diluted with ethyl acetate, washed with an aqueous sodium bicarbonate solution three times, and then washed with brine. The obtained organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give Compound aa155-b (9H-fluoren-9-ylmethyl(4R)-4-[(tert-butyldisulfanyl)methyl]-5-oxo-1,3-oxazolidine-3-carboxylate, 23 g) as a crude product. 
     LCMS (ESI) m/z=466.1 (M+Na)+ 
     Retention time: 1.560 min (analysis condition SMDmethod_20) 
     To a mixture of Compound aa155-b (9H-fluoren-9-ylmethyl(4R)-4-[(tert-butyldisulfanyl)methyl]-5-oxo-1,3-oxazolidine-3-carboxylate, 23 g) obtained above and triethylsilane (60.2 g, 518 mmol) in dichloromethane (120 mL) was added trifluoroacetic acid (120 mL) at room temperature under a nitrogen atmosphere, and the mixture was stirred for 40 hours. The solvent was evaporated from the reaction solution under reduced pressure, and the resulting residue was purified by reverse phase column chromatography (C18, acetonitrile/water) to give Compound aa155-c, (2R)-3-(tert-butyldisulfanyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino] propanoic acid (13 g, 63% through two steps). 
     LCMS (ESI) m/z=446.1 (M+H)+ 
     Retention time: 0.852 min (analysis condition SMDmethod_30) 
     Synthesis of Compound aa155-d, 9H-fluoren-9-ylmethyl N-[(2R)-3-(tert-butyldisulfanyl)-1-(dimethylamino)-1-oxopropan-2-yl]-N-methylcarbamate 
     Under a nitrogen atmosphere, Compound aa155-c ((2R)-3-(tert-butyldisulfanyl)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid, 13.0 g, 29.2 mmol), WSCI—HCl (6.49 g, 33.84 mmol, 1.2 equivalents), and 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine (HOOBt) (5.23 g, 32.09 mmol, 1.1 equivalents) were added to a mixture of DMF (26 mL) and DCM (90 mL) at room temperature, and the mixture was stirred for five minutes. The obtained reaction solution was cooled to 0° C., and dimethylamine (a solution of 2 mol/L in THF, 15.60 mL, 31.2 mmol, 1.07 equivalents) was added dropwise, and the reaction solution was stirred at 0° C. for one hour. The reaction solution was diluted with ethyl acetate, washed with hydrochloric acid (1 mol/L, 130 mL) twice, then washed with water (130 mL) once, washed with an aqueous sodium bicarbonate solution (130 mL) twice, and washed with brine (130 mL) once. The obtained organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure. The resulting residue was purified by normal phase chromatography (petroleum ether/ethyl acetate) to give Compound aa155-d (9H-fluoren-9-ylmethyl N-[(2R)-3-(tert-butyldisulfanyl)-1-(dimethylamino)-1-oxopropan-2-yl]-N-methylcarbamate, 12.1 g, 88%). 
     LCMS (ESI) m/z=495.2 (M+Na)+ 
     Retention time: 1.546 min (analysis condition SMDmethod_20) 
     Synthesis of Compound aa155-e, 9H-fluoren-9-ylmethyl N-[(2R)-1-(dimethylamino)-1-oxo-3-sulfanylpropan-2-yl]-N-methylcarbamate 
     Under a nitrogen atmosphere, to a mixture of Compound aa155-d (9H-fluoren-9-ylmethyl N-[(2R)-3-(tert-butyldisulfanyl)-1-(dimethylamino)-1-oxopropan-2-yl]-N-methylcarbamate, 11.7 g, 24.7 mmol) in ethanol (100 mL), DCM (150 mL), and water (25 mL), tri-n-butylphosphine (6.0 g, 29.7 mmol, 1.2 equivalents) was added dropwise at room temperature, and the mixture was stirred for three hours at room temperature. The reaction solution was extracted with dichloromethane (DCM), and the resulting organic layer was washed with brine, dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure. The resulting residue was purified by normal phase chromatography (petroleum ether/ethyl acetate), and the resulting mixture was purified by reverse phase column chromatography (C18, acetonitrile/water) to give Compound aa155-e (9H-fluoren-9-ylmethyl N-[(2R)-1-(dimethylamino)-1-oxo-3-sulfanylpropan-2-yl]-N-methylcarbamate, 3.03 g, 32%). 
     LCMS (ESI) m/z=407.2 (M+Na)+ 
     Retention time: 1.326 min (analysis condition SMDmethod_20) 
     Synthesis of Compound aa155, 2-[(2R)-3-(dimethylamino)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-oxopropyl]sulfanylacetic acid 
     A mixture of Compound aa155-e (9H-fluoren-9-ylmethyl N-[(2R)-1-(dimethylamino)-1-oxo-3-sulfanylpropan-2-yl]-N-methylcarbamate, 2.80 g, 7.29 mmol) and tert-butyl bromoacetic acid (2.10 g, 10.77 mmol, 1.5 equivalents) in DMF (40 mL) was stirred at room temperature for five minutes, cesium carbonate (2.80 g, 8.59 mmol, 1.2 equivalents) was added thereto, and the mixture was stirred for one hour. The reaction solution was diluted with ethyl acetate and washed with water. The obtained organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give Compound aa155-f (tert-butyl 2-[(2R)-3-(dimethylamino)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-oxopropyl]sulfanyl acetate, 3.1 g) as a crude product. The obtained crude product was used for the next reaction without further purification. 
     LCMS (ESI) m/z=499.3 (M+H)+ 
     Retention time: 1.467 min (analysis condition SMDmethod_20) 
     Compound aa155-f (tert-butyl 2-[(2R)-3-(dimethylamino)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-oxopropyl]sulfanyl acetate, 3.1 g) obtained above was dissolved in a mixture of trifluoroacetic acid (TFA) (30 mL) and dichloromethane (DCM) (30 mL), and the mixture was stirred for two hours at room temperature under a nitrogen atmosphere. The solvent was evaporated from the reaction solution under reduced pressure, and the resulting residue was purified by reverse phase column chromatography (C18, acetonitrile/water). The obtained mixture was further purified by reverse phase high-performance column chromatography (acetonitrile/water, containing TFA), and the resulting eluate was extracted with DCM. The obtained organic layer was sequentially washed with water and hydrochloric acid (1 mol/L), and the solvent was evaporated under reduced pressure to give Compound aa155 (2-[(2R)-3-(dimethylamino)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-oxopropyl]sulfanylacetic acid, 1.79 g, 55% through two steps). 
     LCMS (ESI) m/z=443.2 (M+H)+ 
     Retention time: 1.383 min (analysis condition SMDmethod_31) 
     1-2. Synthesis of Amino Acid-Loaded Resins Used for Solid-Phase Peptide Synthesis by an Automated Synthesizer 
     Amino acids listed in Table 6 were synthesized by the methods provided below, and were loaded on resins and used for peptide synthesis using a peptide synthesizer. Amino acids listed in Table 7 were purchased from commercial suppliers, and were loaded on resins and used for peptide synthesis using a peptide synthesizer. Fmoc amino acids were loaded on resins according to the method described in WO 2013/100132 or WO 2018/225864. 2-Chlorotrityl chloride resin (100-200 mesh, 1% DVB) was purchased from Watanabe Chemical Industries, Ltd. and Chem-Impex. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 6 
               
               
                   
               
               
                 Compound  
                   
                   
                 Name 
               
               
                 No. 
                 Abbreviation 
                 Structural formula 
               
               
                   
               
             
            
               
                 aa006 
                 Fmoc-MeAsp-pip 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-[9H-fluoren-9- ylmethoxycarbonyl(methyl) amino]-4-oxo-4-piperidin-1- ylbutanoic acid 
               
               
                   
               
               
                 aa007 
                 Fmoc-MeAsp-mor 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-[9H-fluoren-9- ylmethoxycarbonyl(methyl) amino]-4-morpholin-4-yl-4- oxobutanoic acid 
               
               
                   
               
               
                 aa008 
                 Fmoc-MeAsp- pyrro(3-Me2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-4-(3,3-dimethylpyrrolidin- 1-yl)-3-[9H-fluoren-9- ylmethoxycarbonyl(methyl) amino]-4-oxobutanoic acid 
               
               
                   
               
               
                 aa009 
                 Fmoc-MeAsp- piz(oxe) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-[9H-fluoren-9- ylmethoxycarbonyl(methyl) amino]-4-[4-(oxetan-3-yl) piperazin-1-yl]-4-oxobutanoic acid 
               
               
                   
               
               
                 aa010 
                 Fmoc-MeAsp- mor(26-bicyc) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-[9H-fluoren-9- ylmethoxycarbonyl(methyl) amino]-4-(3-oxa-8-azabicyclo [3.2.1]octane-8-yl)-4- oxobutanoic acid 
               
               
                   
               
               
                 aa011 
                 Fmoc-MeAsp-NMe2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-4-(dimethylamino)-3- [9H-fluoren-9- ylmethoxycarbonyl(methyl) amino]-4-oxobutanoic acid 
               
               
                   
               
               
                 aa012 
                 Fmoc-MeAsp-aze 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-4-(azetidin-1-yl)-3-[9H- fluoren-9-ylmethoxycarbonyl (methyl)amino]-4- oxobutanoic acid 
               
               
                   
               
               
                 aa013 
                 Fmoc-MeAsp-pyrro 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-[9H-fluoren-9- ylmethoxycarbonyl(methyl) amino]-4-oxo-4-pyrrolidin-1- ylbutanoic acid 
               
               
                   
               
               
                 aa014 
                 Fmoc-MeAsp- pip(4-Me) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-[9H-fluoren-9- ylmethoxycarbonyl(methyl) amino]-4-(4-methylpiperidin- 1-yl)-4-oxobutanoic acid 
               
               
                   
               
               
                 aa015 
                 Fmoc-MeAsp- mor(SO2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-4-(1,1-dioxo-1,4- thiazinane-4-yl)-3-[9H-fluoren- 9-ylmethoxycarbonyl(methyl) amino]-4-oxobutanoic acid 
               
               
                   
               
               
                 aa016 
                 Fmoc-Asp-piz(oxe) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-(9H-fluoren-9- ylmethoxycarbonylamino)-4- [4-(oxetan-3-yl)piperazin-1-yl]- 4-oxobutanoic acid 
               
               
                   
               
               
                 aa017 
                 Fmoc-Asp- mor(26-bicyc) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-(9H-fluoren-9- ylmethoxycarbonylamino)-4- (3-oxa-8-azabicyclo[3.2.1] octane-8-yl)-4-oxobutanoic acid 
               
               
                   
               
               
                 aa018 
                 Fmoc-Asp-pyrro 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-(9H-fluoren-9- ylmethoxycarbonylamino)-4- oxo-4-pyrrolidin-1-ylbutanoic acid 
               
               
                   
               
               
                 aa019 
                 Fmoc-Asp-NMe2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-4-(dimethylamino)-3- (9H-fluoren-9- ylmethoxycarbonylamino)-4- oxobutanoic acid 
               
               
                   
               
               
                 aa020 
                 Fmoc-Asp-pip-tBu 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-4-(4-tert-butylpiperidin-1- yl)-3-(9H-fluoren-9- ylmethoxycarbonylamino)-4- oxobutanoic acid 
               
               
                   
               
               
                 aa021 
                 Fmoc-Asp-mor(SO2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-4-(1,1-dioxo-1,4- thiazinane-4-yl)-3-(9H-fluoren- 9-ylmethoxycarbonylamino)- 4-oxobutanoic acid 
               
               
                   
               
               
                 aa022 
                 Fmoc-Asp-mor 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-(9H-fluoren-9- ylmethoxycarbonylamino)-4- morpholin-4-yl-4- oxobutanoic acid 
               
               
                   
               
               
                 aa023 
                 Fmoc-Asp-pip(4-Me) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-(9H-fluoren-9- ylmethoxycarbonylamino)-4- (4-methylpiperidin-1-yl)-4- oxobutanoic acid 
               
               
                   
               
               
                 aa024 
                 Fmoc-Asp- pyrro(3-Me2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-4-(3,3-dimethylpyrrolidin- 1-yl)-3-(9H-fluoren-9- ylmethoxycarbonylamino)-4- oxobutanoic acid 
               
               
                   
               
               
                 aa025 
                 Fmoc-MeAsp- pip(345-F6) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-[9H-fluoren-9- ylmethoxycarbonyl(methyl) amino]-4-(3,3,4,4,5,5- hexafluoropiperidin-1-yl)-4- oxobutanoic acid 
               
               
                   
               
               
                 aa026 
                 Fmoc-Asp- pip(345-F6) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-(9H-fluoren-9- ylmethoxycarbonylamino)-4- (3,3,4,4,5,5- hexafluoropiperidin-1-yl)-4- oxobutanoic acid 
               
               
                   
               
               
                 aa027 
                 Fmoc-Asp- pyrro(34-F4) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-(9H-fluoren-9- ylmethoxycarbonylamino)-4- oxo-4-(3,3,4,4- tetrafluoropyrrolidin-1-yl) butanoic acid 
               
               
                   
               
               
                 aa028 
                 Fmoc-MeAsp- pyrro(34-F4) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-[9H-fluoren-9- ylmethoxycarbonyl(methyl) amino]-4-oxo-4-(3,3,4,4- tetrafluoropyrrolidin-1-yl) butanoic acid 
               
               
                   
               
               
                 aa029 
                 Fmoc-Asp-oxz 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-(9H-fluoren-9- ylmethoxycarbonylamino)-4- (1,3-oxazolidin-3-yl)-4- oxobutanoic acid 
               
               
                   
               
               
                 aa030 
                 Fmoc-MeAsp-oxz 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-[9H-fluoren-9- ylmethoxycarbonyl(methyl) amino]-4-(1,3-oxazolidin-3-yl)- 4-oxobutanoic acid 
               
               
                   
               
               
                 aa031 
                 Fmoc-D-MeAsp-pyrro 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3R)-3-[9H-fluoren-9- ylmethoxycarbonyl(methyl) amino]-4-oxo-4-pyrrolidin-1- ylbutanoic acid 
               
               
                   
               
               
                 aa032 
                 Fmoc-EtAsp-pip 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-[ethyl(9H-fluoren-9- ylmethoxycarbonyl)amino]- 4-oxo-4-piperidin-1- ylbutanoic acid 
               
               
                   
               
               
                 aa051 
                 D-MeLeu- (C#CH2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3R)-5-methyl-3- (methylamino)hexanoic acid 
               
               
                   
               
               
                 aa052 
                 nPrAsp-pip 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-4-oxo-4-piperidin-1-yl-3- (propyl amino)butanoic acid 
               
               
                   
               
               
                 aa107 
                 Fmoc-D- Ser(NtBu-Aca)- (C#CH2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-4-[2-(tert-butyl amino)-2- oxoethoxy]-3-(9H-fluoren-9- yl methoxycarbonyl amino) butanoic acid 
               
               
                   
               
               
                 aa108 
                 Fmoc-D-Ser(iPen)- (C#CH2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-(9H-fluoren-9-yl methoxycarbonyl amino)-4- (3-methyl butoxy)butanoic acid 
               
               
                   
               
               
                 aa149 
                 Fmoc-Asp-pip 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-(9H-fluoren-9-yl methoxycarbonyl amino)-4- oxo-4-piperidin-1-yl butanoic acid 
               
               
                   
               
               
                 aa141 
                 Fmoc-D-Leu- (C#CH2)-OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3R)-3-(9H-fluoren-9-yl methoxycarbonyl amino)-5- methyl hexanoic acid 
               
               
                   
               
               
                 aa155 
                 Fmoc-MeCys(AcOH)- NMe2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[(2R)-3-(dimethylamino)-2- [9H-fluoren-9-yl methoxycarbonyl(methyl) amino]-3-oxo-propyl] sulfanylacetic acid 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 7 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
               
               
                 No. 
                 Abbreviation 
                 Structural formula 
                 Name 
                 CAS No. 
               
               
                   
               
             
            
               
                 aa135 
                 Fmoc-2-ACHxC—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (1R,2R)-2-(9H- fluoren-9-yl- methoxycar- bonylamino)- cyclohexane-1- carboxylic acid    
                 389057-34-5 
               
               
                   
               
               
                 aa136 
                 Fmoc-2-ACPnC—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (1R,2R)-2-(9H- fluoren-9-yl- methoxycar- bonylamino)- cyclopentane- 1-carboxylic acid 
                 359586-69-9 
               
               
                   
               
               
                 aa137 
                 Fmoc-D-(Propargyl)Gly-(C#CH2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3R)-3-(9H- fluoren-9-yl- methoxycar- bonylamino)- hex-5-ynoic acid 
                 332064-94-5 
               
               
                   
               
               
                 aa138 
                 Fmoc-D-3-Abu—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3R)-3-(9H- fluoren-9-yl- methoxycar- bonylamino)- butanoic acid 
                 201864-71-3 
               
               
                   
               
               
                 aa139 
                 Fmoc-D-3-MeAbu—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3R)-3-[9H- fluoren-9-yl- methoxycar- bonyl(methyl)- amino]butanoic acid 
                 1460306-60-8  
               
               
                   
               
               
                 aa140 
                 Fmoc-D-Gly(Allyl)-(C#CH2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3R)-3-(9H- fluoren-9-yl- methoxycar- bonylamino)- hex-5-enoic acid 
                 269726-95-6 
               
               
                   
               
               
                 aa143 
                 Fmoc-D-Pic(2)-(C#CH2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (R)-2-[1-(9H- fluoren-9-yl- methoxycar- bonyl)piperidin- 2-yl]acetic acid 
                 193693-63-9 
               
               
                   
               
               
                 aa144 
                 Fmoc-D-Pro-(C#CH2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[(2R)-1-(9H- fluoren-9-yl- methoxycar- bonyl)pyrroli- din-2-yl]acetic acid 
                 193693-61-7 
               
               
                   
               
               
                 aa145 
                 Fmoc-bMeAla—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-[9H-fluoren- 9-ylmethoxy- carbonyl(meth- yl)amino]pro- panoic acid 
                 172965-84-3 
               
               
                   
               
               
                 aa146 
                 Fmoc-bAla—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-(9H-fluoren- 9-ylmethoxy- carbonylamino)- propanoic acid 
                  35737-10-1 
               
               
                   
               
               
                 aa147 
                 Fmoc-D-Hph-(C#CH2)—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3R)-3-(9H- Fluoren-9-yl- methoxycar- bonylamino)- 5-phenylpenta- noic acid 
                 269398-87-0 
               
               
                   
               
               
                 aa148 
                 Fmoc-3-CF3-bAla—OH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-3-(9H- fluoren-9-yl- methoxycar- bonylamino)- 4,4,4-trifluoro- butanoic acid 
                 1310680-31-9  
               
               
                   
               
            
           
         
       
     
     Synthesis of Compound aa006-resin, (3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) 
     
       
         
         
             
             
         
       
     
     Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) was synthesized by the method described in WO 2018/225864. 
     In the present specification, when a resin is attached to a compound, the resin portion may be indicated as “∘.” In order to specify the point of reaction in the resin portion, the chemical structure of the reaction site may be indicated as a structure connected to “∘.” The above structure shows that the 2-chlorotrityl group on the resin is attached to the side chain carboxylic acid of MeAsp through an ester bond in Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip (Compound aa006-resin). 
     Synthesis of Compound aa007-resin, (3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-morpholin-4-yl-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-mor) 
     
       
         
         
             
             
         
       
     
     WSCI—HCl (0.506 g, 2.64 mmol) was dissolved in DMF (4.4 mL), HOBt (0.356 g, 2.64 mmol) and Compound aa033-b ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-prop-2-enoxybutanoic acid, Fmoc-MeAsp(OAl)—OH) (0.9 g, 2.2 mmol) were added, and the mixture was stirred at 0° C. for 10 minutes. To the reaction solution was added morpholine (0.23 mL, 2.64 mmol) dropwise, and the mixture was stirred at 0° C. for one hour. Ethyl acetate (9 mL) was added to the reaction solution, which was washed with 0.5 N aqueous hydrochloric acid, water, saturated aqueous sodium bicarbonate/water (1/1), and brine/water (1/1) and dried over anhydrous sodium sulfate. The solvent was then evaporated under reduced pressure to give Compound aa007-a as a crude product (522 mg, 50%). 
     LCMS (ESI) m/z=479 (M+H)+ 
     Retention time: 0.87 min (analysis condition SQDFA05) 
     To a solution of Compound aa007-a (446 mg, 0.932 mmol) in DCM (1.86 mL) was added tetrakis(triphenylphosphine)palladium (0) (10.8 mg, 0.0093 mmol), and phenylsilane (0.081 mL, 0.653 mmol) was further added dropwise, then the mixture was stirred at room temperature for 30 minutes. The reaction solution was diluted with TBME and a 5% aqueous sodium bicarbonate solution was added. The organic layer was removed, phosphoric acid (548 mg) was added to the aqueous layer, which was extracted with TBME. The organic layer was washed with brine and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to give Compound aa007 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-morpholin-4-yl-4-oxobutanoic acid, Fmoc-MeAsp-mor) (321 mg, 79%). 
     LCMS(ESI) m/z=439 (M+H)+ 
     Retention time: 0.69 min (analysis condition SQDFA05) 
     Fmoc amino acids were loaded on resins according to the method described in WO 2013/100132 or WO 2018/225864. In a reaction vessel equipped with a filter were placed 2-chlorotrityl chloride resin (1.60 mmol/g, 100-200 mesh, 1% DVB, 1 g, 1.6 mmol) and dehydrated dichloromethane (13.3 mL), and the vessel was shaken at room temperature for 10 minutes. The dichloromethane was removed by applying nitrogen pressure, after which dehydrated methanol (0.259 mL, 6.4 mmol) and diisopropylethylamine (DIPEA) (0.671 mL, 3.84 mmol) were added to a solution of Compound aa007 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-morpholin-4-yl-4-oxobutanoic acid, Fmoc-MeAsp-mor) (317 mg, 0.723 mmol) in dehydrated dichloromethane (13.3 mL), the resulting mixture was added to the reaction vessel, and the vessel was shaken for 30 minutes. The reaction solution was removed by applying nitrogen pressure, after which dehydrated methanol (1.99 mL) and diisopropylethylamine (DIPEA) (0.671 mL) were added to dehydrated dichloromethane (13.3 mL), the resulting mixture was added to the reaction vessel, and the vessel was shaken for 1 hour and 30 minutes. The reaction solution was removed by applying nitrogen pressure, after which dichloromethane was added to the reaction vessel. After shaking for 5 minutes, the reaction solution was removed by applying nitrogen pressure. This operation of washing the resin with dichloromethane was further repeated twice, and the resulting resin was dried under reduced pressure overnight to give Compound aa007-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-morpholin-4-yl-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-mor) (1.22 g, 0.37 mmol/g). 
     The amount of the amino acid loaded on the resin was calculated as follows. The obtained Compound aa007-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-morpholin-4-yl-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-mor) (10.4 mg) was placed in a reaction vessel, DMF (2 mL) was added, and the vessel was shaken at room temperature for one hour. DBU (40 μL) was then added and the mixture was shaken at 30° C. for 30 minutes. DMF (8 mL) was then added to the reaction mixture, and 1 mL of the solution was diluted with DMF (11.5 mL). The absorbance (294 nm) of the resulting diluted solution was measured (using Shimadzu, UV-1600PC (cell length: 1.0 cm)), and the loading amount of Compound aa007-resin was calculated to be 0.370 mmol/g. 
     Another lot synthesized in the same manner with a different loading amount was also used for peptide synthesis. 
     Synthesis of Compound aa008-resin, (3S)-4-(3,3-dimethylpyrrolidin-1-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-pyrro(3-Me2)) 
     
       
         
         
             
             
         
       
     
     Compound aa008-a (359.6 mg, 60%) was obtained by the same method as in the synthesis of Compound aa007-a using Compound aa033-b ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-prop-2-enoxybutanoic acid) (0.5 g, 1.221 mmol) as a starting material and using 3,3-dimethylpyrrolidine instead of morpholine. 
     LCMS (ESI) m/z=491 (M+H)+ 
     Retention time: 0.98 min (analysis condition SQDFA05) 
     Compound aa008 ((3S)-4-(3,3-dimethylpyrrolidin-1-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid, Fmoc-MeAsp-pyrro(3-Me2)) (226.2 mg, 73%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa008-a (338 mg, 0.689 mmol). 
     LCMS (ESI) m/z=451 (M+H)+ 
     Retention time: 0.84 min (analysis condition SQDFA05) 
     Compound aa008-resin ((3S)-4-(3,3-dimethylpyrrolidin-1-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pyrro(3-Me2)) (731 mg, loading amount 0.455 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa008 ((3S)-4-(3,3-dimethylpyrrolidin-1-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid, Fmoc-MeAsp-pyrro(3-Me2)) (226 mg, 0.502 mmol). 
     Synthesis of Compound aa009-resin, (3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-piz(oxe)) 
     
       
         
         
             
             
         
       
     
     Compound aa009-a (466 mg, 89%) was obtained by the same method as in the synthesis of Compound aa007-a using Compound aa033-b ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-prop-2-enoxybutanoic acid) (0.4 g, 0.977 mmol) as a starting material and using 1-(oxetan-3-yl)piperazine instead of morpholine. 
     LCMS (ESI) m/z=534 (M+H)+ 
     Retention time: 0.64 min (analysis condition SQDFA05) 
     A crude product obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa009-a (466 mg, 0.873 mmol) was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa009 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxobutanoic acid, Fmoc-MeAsp-piz(oxe)) (385 mg, 89%). 
     LCMS (ESI) m/z=494 (M+H)+ 
     Retention time: 0.50 min (analysis condition SQDFA05) 
     Compound aa009-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-piz(oxe)) (1.49 g, loading amount 0.266 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa009 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxobutanoic acid, Fmoc-MeAsp-piz(oxe)) (385 mg, 0.78 mmol). 
     Synthesis of Compound aa010-resin, (3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-Mor(26-bicyc)) 
     
       
         
         
             
             
         
       
     
     Compound aa010-a (5.8 g, 94%) was obtained by the same method as in the synthesis of Compound aa007-a using Compound aa033-b ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-prop-2-enoxybutanoic acid) (5 g, 12.21 mmol) as a starting material and using (1R,5S)-3-oxa-8-azabicyclo[3.2.1]octane hydrochloride and one equivalent of DIPEA relative to amine, instead of morpholine. 
     LCMS (ESI) m/z=505 (M+H)+ 
     Retention time: 0.87 min (analysis condition SQDFA05) 
     Compound aa010 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxobutanoic acid, Fmoc-MeAsp-Mor(26-bicyc)) (5.1 g, 96%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa010-a (5.8 g, 11.49 mmol). 
     LCMS (ESI) m/z=465 (M+H)+ 
     Retention time: 0.69 (analysis condition SQDFA05) 
     Compound aa010-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-Mor(26-bicyc)) (18.3 g, loading amount 0.419 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa010 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxobutanoic acid, Fmoc-MeAsp-Mor(26-bicyc)) (5.1 g, 10.98 mmol). 
     Another lot synthesized in the same manner with a different loading amount was also used for peptide synthesis in the present Examples. 
     Synthesis of Compound aa011-resin, (3S)-4-(dimethylamino)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-NMe2) 
     
       
         
         
             
             
         
       
     
     Compound aa011-a (1.47 g, 92%) was obtained by the same method as in the synthesis of Compound aa007-a using Compound aa033-b ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-prop-2-enoxybutanoic acid) (1.5 g, 3.66 mmol) as a starting material and using a solution of dimethylamine in THF (2 mol/L) instead of morpholine. 
     LCMS (ESI) m/z=437 (M+H)+ 
     Retention time: 0.88 min (analysis condition SQDFA05) 
     Compound aa011 ((3S)-4-(dimethylamino)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid, Fmoc-MeAsp-NMe2) (1.30 g, quant.) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa011-a (1.4 g, 3.21 mmol). 
     LCMS (ESI) m/z=397 (M+H)+ 
     Retention time: 0.70 min (analysis condition SQDFA05) 
     Compound aa011-resin ((3S)-4-(dimethylamino)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-NMe2) (4.45 g, loading amount 0.318 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa011 ((3S)-4-(dimethylamino)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid, Fmoc-MeAsp-NMe2) (1.21 g, 3.05 mmol). 
     Another lot synthesized in the same manner with a different loading amount was also used for peptide synthesis in the present Examples. 
     Synthesis of Compound aa012-resin, (3S)-4-(azetidin-1-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-aze) 
     
       
         
         
             
             
         
       
     
     Compound aa012-a (1.41 g, 86%) was obtained by the same method as in the synthesis of Compound aa007-a using Compound aa033-b ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-prop-2-enoxybutanoic acid) (1.5 g, 3.66 mmol) as a starting material and using azetidine instead of morpholine. 
     LCMS (ESI) m/z=449 (M+H)+ 
     Retention time: 0.86 min (analysis condition SQDFA05) 
     Compound aa012 ((3S)-4-(azetidin-1-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid, Fmoc-MeAsp-aze) (1.14 g, 89%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa012-a (1.4 g, 3.12 mmol). 
     LCMS (ESI) m/z=409 (M+H)+ 
     Retention time: 0.69 min (analysis condition SQDFA05) 
     Compound aa012-resin ((3S)-4-(azetidin-1-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-aze) (3.64 g, loading amount 0.2984 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa012 ((3S)-4-(azetidin-1-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid, Fmoc-MeAsp-aze) (1.05 g, 2.57 mmol). 
     Another lot synthesized in the same manner with a different loading amount was also used for peptide synthesis in the present Examples. 
     Synthesis of Compound aa013-resin, (3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-ylbutanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-pyrro) 
     
       
         
         
             
             
         
       
     
     Compound aa013-a (30.7 g, 91%) was obtained by the same method as in the synthesis of Compound aa007-a using Compound aa033-b ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-prop-2-enoxybutanoic acid) (30 g, 73.3 mmol) as a starting material and using pyrrolidine instead of morpholine. 
     LCMS (ESI) m/z=463 (M+H)+ 
     Retention time: 0.88 min (analysis condition SQDFA05) 
     Compound aa013 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-ylbutanoic acid, Fmoc-MeAsp-pyrro) (26.2 g, 93%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa013-a (30.7 g, 66.4 mmol). 
     LCMS (ESI) m/z=423 (M+H)+ 
     Retention time: 0.71 min (analysis condition SQDFA05) 
     Compound aa013-resin (9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pyrro) (84.1 g, loading amount 0.5216 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa013 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-ylbutanoic acid, Fmoc-MeAsp-pyrro) (24.6 g, 58.2 mmol). 
     Another lot synthesized in the same manner with a different loading amount was also used for peptide synthesis in the present Examples. 
     Synthesis of Compound aa014-resin, (3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(4-methylpiperidin-1-yl)-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip(4-Me)) 
     
       
         
         
             
             
         
       
     
     A crude product of Compound aa014-a was obtained by the same method as in the synthesis of Compound aa007-a using Compound aa033-b ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-prop-2-enoxybutanoic acid) (0.9 g, 2.198 mmol) as a starting material and using 4-methylpiperidine instead of morpholine. The resulting crude product was purified by reverse phase column chromatography (water-acetonitrile, containing 0.1% formic acid), further dissolved in 20% ethyl acetate-hexane, then washed twice with a saturated aqueous sodium bicarbonate solution and once with a saturated aqueous sodium chloride solution, and dried over anhydrous sodium sulfate, the solvent was then evaporated under reduced pressure to give Compound aa014-a (0.587 g, 54%). 
     LCMS (ESI) m/z=491 (M+H)+ 
     Retention time: 1.02 min (analysis condition SQDFA05) 
     Compound aa014 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(4-methylpiperidin-1-yl)-4-oxobutanoic acid, Fmoc-MeAsp-pip(4-Me)) (376.6 mg, 77%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa014-a (535 mg, 1.09 mmol). 
     LCMS (ESI) m/z=451 (M+H)+ 
     Retention time: 0.85 min (analysis condition SQDFA05) 
     Compound aa014-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(4-methylpiperidin-1-yl)-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip(4-Me)) (1.2 g, loading amount 0.403 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa014 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(4-methylpiperidin-1-yl)-4-oxobutanoic acid, Fmoc-MeAsp-pip(4-Me)) (364 mg, 0.808 mmol). 
     Synthesis of Compound aa015-resin, (3S)-4-(1,1-dioxo-1,4-thiazinan-4-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-mor(SO2)) 
     
       
         
         
             
             
         
       
     
     Compound aa015-a (796.2 mg, 69%) was obtained by the same method as in the synthesis of Compound aa007-a using Compound aa033-b ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-prop-2-enoxybutanoic acid) (0.9 g, 2.198 mmol) as a starting material and using 1,1-dioxido-thiomorpholine instead of morpholine. 
     LCMS (ESI) m/z=527 (M+H)+ 
     Retention time: 0.84 min (analysis condition SQDFA05) 
     Compound aa015 ((3S)-4-(1,1-dioxo-1,4-thiazinan-4-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid, Fmoc-MeAsp-mor(SO2)) (624.2 mg, 91%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa015-a (743 mg, 1.41 mmol). 
     LCMS (ESI) m/z=487 (M+H)+ 
     Retention time: 0.68 min (analysis condition SQDFA05) 
     Compound aa015-resin ((3S)-4-(1,1-dioxo-1,4-thiazinan-4-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-mor(SO2)) (1.85 g, loading amount 0.424 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa015 ((3S)-4-(1,1-dioxo-1,4-thiazinan-4-yl)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid, Fmoc-MeAsp-mor(SO2)) (606.7 mg, 1.247 mmol). 
     Synthesis of Compound aa016-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-Asp(0-Trt(2-Cl)resinl-niz(oxel) 
     
       
         
         
             
             
         
       
     
     Compound aa016-a (499 mg, 95%) was obtained by the same method as in the synthesis of Compound aa007-a using Fmoc-Asp(OAl)—OH ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-prop-2-enoxybutanoic acid, CAS No. 146982-24-3) (0.4 g, 1.012 mmol) as a starting material and using 1-(oxetan-3-yl)piperazine instead of morpholine. 
     LCMS (ESI) m/z=520 (M+H)+ 
     Retention time: 0.60 min (analysis condition SQDFA05) 
     Compound aa016 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxobutanoic acid (Fmoc-Asp-piz(oxe)) (415 mg, 90%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa016-a (499 mg, 0.960 mmol). 
     LCMS (ESI) m/z=480 (M+H)+ 
     Retention time: 0.49 min (analysis condition SQDFA05) 
     Compound aa016-resin ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-Asp(O-Trt(2-Cl)resin)-piz(oxe)) (463 mg, loading amount 0.329 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa016 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[4-(oxetan-3-yl)piperazin-1-yl]-4-oxobutanoic acid (Fmoc-Asp-piz(oxe)) (123 mg, 0.256 mmol). 
     Synthesis of Compound aa017-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)resin)-Mor(26-bicyc)) 
     
       
         
         
             
             
         
       
     
     Compound aa017-a (706 mg, 95%) was obtained by the same method as in the synthesis of Compound aa007-a using Fmoc-Asp(OAl)—OH ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-prop-2-enoxybutanoic acid, CAS No. 146982-24-3) (0.6 g, 1.517 mmol) as a starting material and using (1R,5S)-3-oxa-8-azabicyclo[3.2.1]octane hydrochloride and one equivalent of DIPEA relative to amine, instead of morpholine. 
     LCMS (ESI) m/z=491 (M+H)+ 
     Retention time: 0.82 (analysis condition SQDFA05) 
     Compound aa017 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxobutanoic acid, Fmoc-Asp-Mor(26-bicyc)) (564.5 mg, 87%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa017-a (705 mg, 1.437 mmol). 
     LCMS (ESI) m/z=451 (M+H)+ 
     Retention time: 0.66 min (analysis condition SQDFA05) 
     Compound aa017-resin ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-Asp(O-Trt(2-Cl)resin)-Mor(26-bicyc)) (464 mg, loading amount 0.340 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa017 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxobutanoic acid, Fmoc-Asp-Mor(26-bicyc)) (115 mg, 0.256 mmol). 
     Another lot synthesized in the same manner with a different loading amount was also used for peptide synthesis in the present Examples. 
     Synthesis of Compound aa018-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-pyrrolidin-1-ylbutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)-resin)-pyrro) 
     
       
         
         
             
             
         
       
     
     To DMF (600 mL) were sequentially added WSCI—HCl (67.1 g, 350 mmol), HOBt (43.4 g, 321 mmol), and Fmoc-Asp(OtBu)-OH (120 g, 292 mmol) at 0° C. under a nitrogen atmosphere, and the mixture was stirred at 0° C. for one hour. To this reaction solution was slowly added pyrrolidine (26.3 mL, 321 mmol), and the mixture was stirred at 0° C. for 1.5 hours. To the reaction solution were added Ethyl acetate (10 v) and 0.5 mol/L aqueous hydrochloric acid (2 v) at 0° C., and the organic layer was separated. The resulting organic layer was sequentially washed with 0.5 mol/L aqueous hydrochloric acid, water, saturated aqueous sodium bicarbonate/water (1/1), and brine/water (1/1) and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to give Compound aa018-a as a crude product (137.1 g, quant.). 
     LCMS (ESI) m/z=465 (M+H)+ 
     Retention time: 1.05 min (analysis condition SQDAA05) 
     To a solution of Compound aa018-a (137 g, 395 mmol) in DCM (137 mL) was slowly added TFA (271 mL) under ice-cooling such that the internal temperature did not exceed 10° C. After stirring at room temperature for one hour, diisopropyl ether (3.4 L) were added in four portions, and the precipitated solid was collected by filtration and dried to give Compound aa018 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-pyrrolidin-1-ylbutanoic acid, Fmoc-Asp-pyrro) (108.4 g, 90%). 
     LCMS(ESI) m/z=409 (M+H)+ 
     Retention time: 0.83 min (analysis condition SQDAA05) 
     Compound aa017-resin ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-pyrrolidin-1-ylbutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)-resin)-pyrro)) (59.79 g, loading amount 0.464 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using Compound aa018 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-pyrrolidin-1-ylbutanoic acid, Fmoc-Asp-pyrro) (15.91 g, 30 mmol). 
     Another lot synthesized in the same manner with a different loading amount was also used for peptide synthesis in the present Examples. 
     Synthesis of Compound aa019-resin, (3S)-4-(dimethylamino)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)resin)-NMe2) 
     
       
         
         
             
             
         
       
     
     To a solution of Fmoc-Asp(OtBu)-OH (4-tert-butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartate, CAS No. 71989-14-5) (5 g, 12.15 mmol) and HOBt monohydrate (2.047 g, 13.37 mmol) in DMF (24.3 mL) were sequentially added dimethylamine hydrochloride (0.991 g, 12.15 mmol), WSCI—HCl (2.8 g, 14.58 mmol), and DIPEA (2.117 mL, 12.15 mmol) at 0° C. under a nitrogen atmosphere, and the mixture was stirred at 0° C. for 50 minutes. To the reaction solution were added ethyl acetate/hexane (1/1, 100 mL) and brine/water (1/1, 50 mL), and the organic layer was separated. The resulting organic layer was sequentially washed with a saturated aqueous ammonium chloride solution, water, and brine and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give Compound aa019-a (5.02 g, 94%). 
     LCMS (ESI) m/z=439 (M+H)+ 
     Retention time: 1.03 min (analysis condition SQDAA05) 
     To Compound aa019-a (5 g, 11.4 mmol) was added toluene (150 mL) and the solvent was evaporated under reduced pressure. This operation was performed three times. The residue was dissolved in DCM (5.06 mL), TFA (10.13 mL, 137 mmol) was added dropwise at 0° C. under a nitrogen atmosphere, and the mixture was stirred at room temperature for one hour. The reaction solution was cooled at 0° C., diethyl ether (10.1 mL) was added, and a 8 mol/L aqueous sodium hydroxide solution (17.1 mL) was added dropwise. A saturated aqueous sodium dihydrogenphosphate solution (7.6 mL) and water (5 mL) were further added. The solution was extracted with ethyl acetate, and the resulting organic layer was washed with saturated aqueous sodium dihydrogenphosphate/water (1/1) and dried over anhydrous sodium sulfate, after which the solvent was evaporated under reduced pressure to give Compound aa019 ((3S)-4-(dimethylamino)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid, Fmoc-Asp-NMe2) (2.63 g, 60%), which was used for the next reaction without further purification. 
     LCMS (ESI) m/z=383 (M+H)+ 
     Retention time: 0.80 min (analysis condition SQD compound AA05) 
     Compound aa019-resin ((3S)-4-(dimethylamino)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-Asp(O-Trt(2-Cl)resin)-NMe2) (9.07 g, loading amount 0.399 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa019 ((3S)-4-(dimethylamino)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid, Fmoc-Asp-NMe2) (2.367 g, 6.19 mmol). 
     Another lot synthesized in the same manner with a different loading amount was also used for peptide synthesis in the present Examples. 
     Synthesis of Compound aa020-resin, (3S)-4-(4-tert-butylpiperidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)resin)-pip-tBu) 
     
       
         
         
             
             
         
       
     
     Compound aa020-a (11.5 g, 93%) was obtained by the same method as in the synthesis of Compound aa019-a using Fmoc-Asp(OtBu)-OH (4-tert-butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartate, CAS No. 71989-14-5) (10 g, 24.3 mmol) as a starting material, using 4-(tert-butyl)piperidine hydrochloride instead of dimethylamine hydrochloride, and using 1.0 equivalent of 4-methylmorpholine relative to amine, instead of DIPEA. 
     LCMS (ESI) m/z=535.4 (M+H)+ 
     Retention time: 1.19 min (analysis condition SQDAA05) 
     To Compound aa020-a (2 g, 3.74 mmol) was added toluene (150 mL) and the solvent was evaporated under reduced pressure. This operation was performed three times. The residue was dissolved in DCM (1.66 mL), TFA (1.66 mL, 22.44 mmol) was added dropwise at 0° C. under a nitrogen atmosphere, and the mixture was stirred at room temperature for 4 h. The reaction solution was cooled to 0° C. and triethylamine (3.13 mL, 22.4 mmol) was added dropwise. This solution was diluted with DCM (30 mL) and washed with an aqueous sodium dihydrogenphosphate solution (5%) nine times. The organic layer was dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to give Compound aa020 ((3S)-4-(4-tert-butylpiperidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid, Fmoc-Asp-pip-tBu) (1.73 g, 96%). 
     LCMS (ESI) m/z=479.4 (M+H)+ 
     Retention time: 1.02 min (analysis condition SQDAA05) 
     Compound aa020-resin ((3S)-4-(4-tert-butylpiperidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-Asp(O-Trt(2-Cl)resin)-pip-tBu) (5.23 g, loading amount 0.356 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa020 ((3S)-4-(4-tert-butylpiperidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid, Fmoc-Asp-pip-tBu) (1.73 g, 3.61 mmol). 
     Synthesis of Compound aa021-resin, (3S)-4-(1,1-dioxo-1,4-thiazinan-4-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-Asp(0-Trt(2-Cl)resin)-mor(SO2)) 
     
       
         
         
             
             
         
       
     
     Compound aa021-a (492 mg, 38%) was obtained by the same method as in the synthesis of Compound aa019-a using Fmoc-Asp(OtBu)-OH (4-tert-butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartate, CAS No. 71989-14-5) (1 g, 2.43 mmol) as a starting material and using 1,1-dioxido-thiomorpholine instead of dimethylamine hydrochloride and DIPEA. 
     LCMS (ESI) m/z=551 (M+Na)+ 
     Retention time: 0.86 min (analysis condition SQDFA05) 
     Compound aa021 ((3S)-4-(1,1-dioxo-1,4-thiazinan-4-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid, Fmoc-Asp-mor(SO2)) (356.4 mg, 95%) was obtained by the same method as in the synthesis of Compound aa020 using the obtained Compound aa021-a (420 mg, 0.795 mmol). 
     LCMS (ESI) m/z=473 (M+H)+ 
     Retention time: 0.67 min (analysis condition SQDFA05) 
     Compound aa021-resin ((3S)-4-(1,1-dioxo-1,4-thiazinan-4-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-Asp(O-Trt(2-Cl)resin)-mor(SO2)) (1.16 g, loading amount 0.371 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa021 ((3S)-4-(1,1-dioxo-1,4-thiazinan-4-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid, Fmoc-Asp-mor(SO2)) (346 mg, 0.773 mmol). 
     Synthesis of Compound aa022-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-morpholin-4-yl-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)resin)-mor) 
     
       
         
         
             
             
         
       
     
     Compound aa022-a (713 mg, 61%) was obtained by the same method as in the synthesis of Compound aa019-a using Fmoc-Asp(OtBu)-OH (4-tert-butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartate, CAS No. 71989-14-5) (1 g, 2.43 mmol) as a starting material and using morpholine instead of dimethylamine hydrochloride and DIPEA. 
     LCMS (ESI) m/z=481 (M+H)+ 
     Retention time: 0.88 min (analysis condition SQDFA05) 
     Compound aa022 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-morpholin-4-yl-4-oxobutanoic acid, Fmoc-Asp-mor) (353.4 mg, 100%) was obtained by the same method as in the synthesis of Compound aa020 using the obtained Compound aa022-a (400 mg, 0.832 mmol). 
     LCMS (ESI) m/z=425 (M+H)+ 
     Retention time: 0.66 min (analysis condition SQDFA05) 
     Compound aa022-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-morpholin-4-yl-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)resin)-mor) (1.21 g, loading amount 0.415 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa022 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-morpholin-4-yl-4-oxobutanoic acid, Fmoc-Asp-mor) (326 mg, 0.768 mmol). 
     Another lot synthesized in the same manner with a different loading amount was also used for peptide synthesis in the present Examples. 
     Synthesis of Compound aa023-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(4-methylpiperidin-1-yl)-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)resin)-pip(4-Me) 
     
       
         
         
             
             
         
       
     
     A crude product of Compound aa023-a was obtained by the same method as in the synthesis of Compound aa019-a using Fmoc-Asp(OtBu)-OH (4-tert-butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartate, CAS No. 71989-14-5) (1 g, 2.43 mmol) as a starting material and using 4-methylpiperidine instead of dimethylamine hydrochloride and DIPEA. The resulting crude product was dissolved in 20% ethyl acetate-hexane, washed three times with a saturated aqueous sodium bicarbonate solution and once with brine, and dried over anhydrous sodium sulfate, after which the solvent was evaporated under reduced pressure to give Compound aa023-a (430 mg, 36%). 
     LCMS (ESI) m/z=493 (M+H)+ 
     Retention time: 0.74 min (analysis condition SQDAA50) 
     Compound aa023 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(4-methylpiperidin-1-yl)-4-oxobutanoic acid, Fmoc-Asp-pip(4-Me)) (326.5 mg, quant.) was obtained by the same method as in the synthesis of Compound aa020 using the obtained Compound aa023-a (359 mg, 0.728 mmol). 
     LCMS (ESI) m/z=437 (M+H)+ 
     Retention time: 0.80 min (analysis condition SQDFA05) 
     Compound aa023-resin ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(4-methylpiperidin-1-yl)-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-Asp(O-Trt(2-Cl)resin)-pip(4-Me)) (1.07 g, loading amount 0.363 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa023 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(4-methylpiperidin-1-yl)-4-oxobutanoic acid, Fmoc-Asp-pip(4-Me)) (315 mg, 0.722 mmol). 
     Synthesis of Compound aa024-resin, (3S)-4-(3,3-dimethylpyrrolidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)resin)-pyrro(3-Me2)) 
     
       
         
         
             
             
         
       
     
     Compound aa024-a (1.36 g, 56%) was obtained by the same method as in the synthesis of Compound aa007-a using Fmoc-Asp(OAl)—OH ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-prop-2-enoxybutanoic acid, CAS No. 146982-24-3) (2 g, 5.06 mmol) as a starting material and using 3,3-dimethylpyrrolidine instead of morpholine. 
     LCMS (ESI) m/z=477 (M+H)+ 
     Retention time: 1.322 min (analysis condition SMDmethod_04) 
     Compound aa024 ((3S)-4-(3,3-dimethylpyrrolidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid, Fmoc-Asp-pyrro(3-Me2)) (1.041 g, 90%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa024-a (1.269 g, 2.66 mmol). 
     LCMS (ESI) m/z=437 (M+H)+ 
     Retention time: 0.81 min (analysis condition SQDFA05) 
     Compound aa024-resin ((3S)-4-(3,3-dimethylpyrrolidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-Asp(O-Trt(2-Cl)resin)-pyrro(3-Me2)) (4.16 g, loading amount 0.569 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa024 ((3S)-4-(3,3-dimethylpyrrolidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid, Fmoc-Asp-pyrro(3-Me2)) (1.903 g, 5.81 mmol). 
     Synthesis of Compound aa025-resin, (3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(3,3,4,4,5,5-hexafluoropiperidin-1-yl)-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip(345-F6)) 
     
       
         
         
             
             
         
       
     
     To a suspension of Compound aa033-b ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-prop-2-enoxybutanoic acid) (0.62 g, 1.57 mmol) in DCM (7.8 mL, 0.2 M) were added thionyl chloride (0.136 mL, 1.88 mmol, 1.2 equivalents) and DMF (0.00607 mL, 0.078 mmol, 5 mol %) at room temperature, and the mixture was stirred for four hours. The reaction solution was concentrated, after which the resulting solution of the crude product in DCM (3 mL) was added to a mixed suspension composed of a solution of 3,3,4,4,5,5-hexafluoropiperidine hydrochloride (300 mg, 1.31 mmol) in DCM (10 mL) and a 1 mol/L aqueous sodium hydroxide solution (13 mL) at room temperature, and the mixture was stirred for 1.5 hours. The reaction solution was extracted with TBME twice, and the resulting organic layers were washed with water, dried over sodium sulfate, and then concentrated under reduced pressure to give a crude product. The resulting crude product was purified by medium pressure reverse phase column chromatography to give Compound aa025-a (587 mg, 77%). 
     LCMS (ESI) m/z=585 (M+H)+ 
     Retention time: 1.03 min (analysis condition SQDFA05) 
     Compound aa025 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(3,3,4,4,5,5-hexafluoropiperidin-1-yl)-4-oxobutanoic acid, Fmoc-MeAsp-pip(345-F6)) (413 mg, 81%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa025-a (550 mg, 0.941 mmol). 
     LCMS (ESI) m/z=545 (M+H)+ 
     Retention time: 0.89 min (analysis condition SQDFA05) 
     Compound aa025-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(3,3,4,4,5,5-hexafluoropiperidin-1-yl)-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip(345-F6)) (1.17 g, loading amount 0.315 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa025 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(3,3,4,4,5,5-hexafluoropiperidin-1-yl)-4-oxobutanoic acid, Fmoc-MeAsp-pip(345-F6)) (327 mg, 0.6 mmol). 
     Synthesis of Compound aa026-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3,3,4,4,5,5-hexafluoropiperidin-1-yl)-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)resin)-pip(345-F61) 
     
       
         
         
             
             
         
       
     
     Compound aa026-a (552 mg, 74%) was obtained by the same method as in the synthesis of Compound aa025-a using Fmoc-Asp(OAl)—OH ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-prop-2-enoxybutanoic acid, CAS No. 146982-24-3) (649 mg, 1.568 mmol) as a starting material. 
     LCMS (ESI) m/z=571 (M+H)+ 
     Retention time: 0.97 min (analysis condition SQDFA05) 
     Compound aa026 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3,3,4,4,5,5-hexafluoropiperidin-1-yl)-4-oxobutanoic acid, Fmoc-Asp-pip(345-F6)) (462 mg, 90%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa026-a (552 mg, 0.968 mmol). 
     LCMS (ESI) m/z=531 (M+H)+ 
     Retention time: 0.84 min (analysis condition SQDFA05) 
     Compound aa026-resin ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3,3,4,4,5,5-hexafluoropiperidin-1-yl)-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-Asp(O-Trt(2-Cl)resin)-pip(345-F6)) (1.64 g, loading amount 0.309 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa026 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3,3,4,4,5,5-hexafluoropiperidin-1-yl)-4-oxobutanoic acid, Fmoc-Asp-pip(345-F6)) (446 mg, 0.84 mmol). 
     Synthesis of Compound aa027-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)butanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)resin)-pyrro(34-F4)) 
     
       
         
         
             
             
         
       
     
     Compound aa027-a (478 mg, 91%) was obtained by the same method as in the synthesis of Compound aa025-a using Fmoc-Asp(OAl)—OH ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-prop-2-enoxybutanoic acid, CAS No. 146982-24-3) (0.62 g, 1.568 mmol) as a starting material and using 3,3,4,4-tetrafluoropyrrolidine hydrochloride instead of 3,3,4,4,5,5-hexafluoropiperidine hydrochloride. 
     LCMS (ESI) m/z=521 (M+H)+ 
     Retention time: 0.95 min (analysis condition SQDFA05) 
     Compound aa027 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)butanoic acid, Fmoc-Asp-pyrro(34-F4)) (388 mg, quant.) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa027-a (416 mg, 0.799 mmol). 
     LCMS (ESI) m/z=481 (M+H)+ 
     Retention time: 0.81 min (analysis condition SQDFA05) 
     Compound aa027-resin ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)butanoic acid-2-chlorotrityl resin, Fmoc-Asp(O-Trt(2-Cl)resin)-pyrro(34-F4)) (1.74 g, loading amount 0.343 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa027 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)butanoic acid, Fmoc-Asp-pyrro(34-F4)) (0.388 g, 0.808 mmol). 
     Synthesis of Compound aa028-resin, (3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)butanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-pyrro(34-F4)) 
     
       
         
         
             
             
         
       
     
     Compound aa028-a (490 mg, 90%) was obtained by the same method as in the synthesis of Compound aa025-a using Compound aa033-b ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-prop-2-enoxybutanoic acid) (0.416 mg, 1.208 mmol) as a starting material and using 3,3,4,4-tetrafluoropyrrolidine hydrochloride instead of 3,3,4,4,5,5-hexafluoropiperidine hydrochloride. 
     LCMS (ESI) m/z=535 (M+H)+ 
     Retention time: 0.99 min (analysis condition SQDFA05) 
     Compound aa028 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)butanoic acid, Fmoc-MeAsp-pyrro(34-F4)) (388 mg, 97%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa028-a (450 mg, 0.842 mmol). 
     LCMS (ESI) m/z=495 (M+H)+ 
     Retention time: 0.83 min (analysis condition SQDFA05) 
     Compound aa028-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)butanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pyrro(34-F4)) (1.88 g, loading amount 0.355 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa028 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)butanoic acid, Fmoc-MeAsp-pyrro(34-F4)) (388 mg, 0.785 mmol). 
     Synthesis of Compound aa029-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(1,3-oxazolidin-3-yl)-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)resin)-oxz) 
     
       
         
         
             
             
         
       
     
     To a solution of Fmoc-Asp(OAl)—OH ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-prop-2-enoxybutanoic acid, CAS No. 146982-24-3) (700 mg, 1.77 mmol) and HATU (740 mg, 1.1 equivalents) in DMF (3.5 mL, 0.5 M) was added DIPEA (229 mg, 1 equivalent), and the mixture was stirred at room temperature for 5 minutes, after which oxazolidine (155 mg, 1.2 equivalents) was added and the mixture was stirred for 15 minutes. Water was added to the reaction solution, which was then extracted with TBME and DCM. The solvent was evaporated from the resulting organic layer under reduced pressure. The resulting crude product was purified by medium pressure reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa029-a (456.7 mg, 57%). 
     LCMS (ESI) m/z=451 (M+H)+ 
     Retention time: 0.82 min (analysis condition SQDFA05) 
     Compound aa029 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(1,3-oxazolidin-3-yl)-4-oxobutanoic acid, Fmoc-Asp-oxz) (426 mg, quant.) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa029-a (444 mg, 0.985 mmol). 
     LCMS (ESI) m/z=411 (M+H)+ 
     Retention time: 0.67 min (analysis condition SQDFA05) 
     Compound aa029-resin ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(1,3-oxazolidin-3-yl)-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-Asp(O-Trt(2-Cl)resin)-oxz) (1.99 g, loading amount 0.285 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa029 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(1,3-oxazolidin-3-yl)-4-oxobutanoic acid, Fmoc-Asp-oxz) (425 mg, 1.036 mmol). 
     Synthesis of Compound aa030-resin, (3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(1,3-oxazolidin-3-yl)-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-oxz 
     
       
         
         
             
             
         
       
     
     Compound aa030-a (164 mg, 20%) was obtained by the same method as in the synthesis of Compound aa029-a using Compound aa033-b ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-prop-2-enoxybutanoic acid) (725 mg, 1.77 mmol) as a starting material. 
     LCMS (ESI) m/z=465 (M+H)+ 
     Retention time: 0.86 min (analysis condition SQDFA05) 
     Compound aa030 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(1,3-oxazolidin-3-yl)-4-oxobutanoic acid, Fmoc-MeAsp-oxz) (111 mg, 83%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa030-a (146.4 mg, 0.315 mmol). Another lot synthesized in the same manner was added thereto, and the next reaction was performed. 
     LCMS (ESI) m/z=425 (M+H)+ 
     Retention time: 0.69 min (analysis condition SQDFA05) 
     Compound aa030-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(1,3-oxazolidin-3-yl)-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-oxz) (1.06 g, loading amount 0.283 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa030 ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(1,3-oxazolidin-3-yl)-4-oxobutanoic acid, Fmoc-MeAsp-oxz) (0.25 g, 0.589 mmol). 
     Synthesis of Compound aa031-resin, (3R)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-ylbutanoic acid-2-chlorotrityl resin (Fmoc-D-MeAsp(O-Trt(2-Cl)resin)-pyrro) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Fmoc-D-Asp(OAl)—OH ((2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-prop-2-enoxybutanoic acid) (780 mg, 1.97 mmol) was suspended in toluene (10 ml), paraformaldehyde (178 mg, 5.92 mmol) and CSA (22.9 mg, 0.10 mmol) were added, and the mixture was stirred at 85° C. for two hours. After cooling to room temperature, a saturated aqueous sodium bicarbonate solution was added and the mixture was extracted with ethyl acetate. The organic layer was washed with brine/water (1/1) and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to give Compound aa031-a as a crude product. The next reaction was performed without further purification. 
     Compound aa031-a was dissolved dichloromethane (10 mL), boron trifluoride-diethyl ether complex (0.50 mL, 3.95 mmol) and triethylsilane (0.63 mL, 3.95 mmol) were added, and the mixture was stirred at room temperature for three hours. A saturated aqueous ammonium chloride solution was added to the reaction solution, and the mixture was extracted with dichloromethane. The organic layer was washed with brine and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure. The resulting concentrate was dissolved in acetonitrile and washed with hexane. The solvent was evaporated from the acetonitrile layer under reduced pressure to give Compound aa031-b (530 mg) as a crude product. The next reaction was performed without further purification. 
     Compound aa031-b (530 mg, 1.29 mmol) was dissolved in DMF (5 mL), HOBt-monohydrate (218 mg, 1.42 mmol) and WSCI—HCl (298 mg, 1.55 mmol) were added, and the mixture was stirred at 0° C. for 30 minutes. To the reaction solution was added pyrrolidine (0.11 ml, 1.29 mmol), and the mixture was further stirred at room temperature for 30 minutes. To the reaction solution was added a 0.5 N aqueous hydrochloric acid solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and brine and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give Compound aa031-c (550 mg, 60% over three steps). 
     LCMS (ESI) m/z=463 (M+H)+ 
     Retention time: 0.89 min (analysis condition SQDFA05) 
     Compound aa031-c (crude, 550 mg, 1.19 mmol) was dissolved in dichloromethane (10 ml), phenylsilane (0.10 ml, 0.83 mmol) and tetrakis(triphenylphosphine)palladium(0) (13.7 mg, 0.012 mmol) were added, and the mixture was stirred at room temperature for one hour. The reaction solution was diluted with TBME and a 5% aqueous sodium bicarbonate solution (40 ml) was added. The organic layer was removed, phosphoric acid (699 mg) was added to the aqueous layer, which was extracted with TBME. The organic layer was washed with brine/water (1/1, 40 mL) and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to give Compound aa031 ((3R)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-ylbutanoic acid, Fmoc-D-MeAsp-pyrro) (334 mg, 67%). 
     LCMS (ESI) m/z=423 (M+H)+ 
     Retention time: 0.71 min (analysis condition SQDFA05) 
     Compound aa031-resin ((3R)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-D-MeAsp(O-Trt(2-Cl)resin)-pyrro) (loading amount 0.423 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa031 ((3R)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-pyrrolidin-1-ylbutanoic acid, Fmoc-D-MeAsp-pyrro) (330 mg, 0.781 mmol). 
     Synthesis of Compound aa032-resin, (3S)-3-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin (Fmoc-EtAsp(O-Trt(2-Cl)resin)-pip) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Fmoc-Asp(OAl)—OH ((2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-prop-2-enoxybutanoic acid, CAS No. 146982-24-3) (5 g, 12.65 mmol, CAS No. 146982-24-3) was suspended in toluene (15.2 mL) under a nitrogen atmosphere, anhydrous magnesium sulfate (4.57 g, 37.9 mmol), paraldehyde (2.53 mL, 19.0 mmol), and TFA (1.94 mL, 25.3 mmol) were added, and the mixture was stirred at 70° C. for five hours. The reaction solution was left to cool to room temperature, washed twice with a mixture of water (10 v), 1 M aqueous dipotassium hydrogenphosphate (K 2 HPO 4 ) solution (3 v), 3.5% aqueous potassium bicarbonate (KHCO 3 ) solution (4 v), and acetonitrile (2 v), and washed with brine/water (1/1, 5 v), and the organic layer was dried over magnesium sulfate. The resulting organic layer was filtered and then concentrated under reduced pressure to give a crude product of aa032-a, which was used for the next reaction without further purification. 
     LCMS (ESI) m/z=422 (M+H)+ 
     Retention time: 0.92 min (analysis condition SQDFA05) 
     To a solution of the crude product containing Compound aa032-a in toluene (16 mL) were added triethylsilane (4.04 mL, 25.3 mmol) and a 1 M solution of titanium tetrachloride (TiCl 4 ) in toluene (25.3 mL, 25.3 mmol) under a nitrogen atmosphere, and the mixture was stirred at room temperature for 50 minutes. The reaction solution was washed with water (5 v) twice and washed with a 1 M aqueous dipotassium hydrogenphosphate (K 2 HPO 4 ) solution (5 v). Hexane (9 v) was added to the resulting organic layer, which was extracted twice with a mixture of 3.5% aqueous potassium bicarbonate (KHCO 3 ) solution (4 v) and acetonitrile (2 v). The resulting aqueous layer was washed with hexane (8 v). The resulting aqueous layer was adjusted to pH 3 or lower with a 85% aqueous phosphoric acid solution and then extracted with TBME (5 v), and the resulting organic layer was washed with brine and then dried over magnesium sulfate. The resulting organic layer was filtered and then concentrated under reduced pressure to give Compound aa032-b (4.85 g, 91% through two steps). 
     LCMS (ESI) m/z=424 (M+H)+ 
     Retention time: 0.85 min (analysis condition SQDFA05) 
     Compound aa032-c (530 mg, 89%) was obtained by the same method as in the synthesis of Compound aa007-a using Compound aa032-b (512 mg, 1.21 mmol) as a starting material and using piperidine instead of morpholine. 
     LCMS (ESI) m/z=491 (M+H)+ 
     Retention time: 0.99 min (analysis condition SQDFA05) 
     Compound aa032 ((3S)-3-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid, Fmoc-EtAsp-pip) (334 mg, 73%) was obtained by the same method as in the synthesis of Compound aa007 using the obtained Compound aa032-c (495 mg, 1.01 mmol). 
     LCMS (ESI) m/z=451 (M+H)+ 
     Retention time: 0.82 min (analysis condition SQDFA05) 
     Compound aa032-resin ((3S)-3-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-EtAsp(O-Trt(2-Cl)resin)-pip) (18.3 g, loading amount 0.350 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound aa032 ((3S)-3-[ethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid, Fmoc-EtAsp-pip) (0.33 g, 0.732 mmol). 
     Synthesis of Compound aa051 ((3R)-5-methyl-3-(methylamino)hexanoic acid-2-chlorotrityl resin, H-D-MeLeu-(C#CH2)—O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     To a reaction vessel equipped with a filter were added Compound aa141-resin (100 mg, 0.0499 mmol, 0.499 mmol/g) and dehydrated DCM (1.0 mL), and the resin was swollen. The DCM was removed, and the resin was then washed with dehydrated DMF (0.7 mL) twice. An Fmoc deprotection solution (a solution (2% v/v) of diazabicycloundecene (DBU) in DMF, 0.7 mL) was added, the vessel was shaken at room temperature for 10 minutes, and the reaction solution was then removed. The resin was washed with dehydrated THF (0.7 mL) four times to give resin-loaded Compound aa051-b. 
     To this were added a nosyl chloride/dehydrated THF solution (using 0.35 mL out of the solution prepared at 0.88 g/7 mL; 0.20 mmol) and a collidine/THF solution (using 0.35 mL out of the solution prepared by diluting collidine (1.35 mL) to 7 mL with THF; 0.50 mmol), and the vessel was shaken at 40° C. for two hours. Next, the reaction solution was removed, and the resin was washed with dehydrated THF (0.7 mL) four times and then washed with dehydrated DCM (0.7 mL) four times to give resin-loaded Compound aa051-c. 
     This was swollen with dehydrated DCM (1.0 mL) and washed with dehydrated THF (0.7 mL) four times, after which a triphenylphosphine/dehydrated THF solution (66.0 mg/0.7 mL, 0.25 mmol), methanol (0.020 mL, 0.50 mmol), and diisopropyl azodicarboxylate (DIAD) (0.05 mL, 0.25 mmol) were added, and the vessel was stirred at 40° C. for 30 minutes. Next, the reaction solution was removed, and the resin was washed with dehydrated THF (0.7 mL) four times and then washed with dehydrated DCM (0.7 mL) four times to give resin-loaded Compound aa051-d. 
     This was swollen with dehydrated DCM (1.0 mL) and washed with dehydrated NMP (0.7 mL) four times, after which a DBU/NMP solution (using 0.35 mL out of the solution prepared by diluting DBU (0.4 mL) to 3.5 mL with dehydrated NMP) and a 1-dodecanethiol/NMP solution (using 0.35 mL out of the solution prepared by duluting 1-dodecanethiol (1.2 mL) to 3.5 mL with dehydrated NMP) were added and the vessel was shaken at 40° C. for one hour. Next, the reaction solution was removed, and the resin was washed with dehydrated NMP (0.7 mL) four times and then washed with dehydrated DCM (0.7 mL) four times to give resin-loaded Compound aa051. 
     A small amount of the resin-loaded Compound aa051 was cleaved from the resin with TFE/DCM (1/1), and the structure of the amino acid was confirmed by LC/MS. 
     LCMS (ESI) m/z=160 (M+H)+ 
     Retention time: 0.30 min (analysis condition SQDAA05) 
     Synthesis of Compound aa052 ((3S)-4-oxo-4-piperidin-1-yl-3-(propylamino)butanoic acid-2-chlorotrityl resin, H-nPrAsp-O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Into a reaction vessel equipped with a filter were placed Compound aa149-resin (3 g, 1.36 mmol, 0.452 mmol/g) and dehydrated DCM (30 mL), and the vessel was shaken at room temperature for 15 minutes. The DCM was removed by applying nitrogen pressure, after which dehydrated DMF (30 mL) was added and the DMF was removed by applying nitrogen pressure. This operation was performed four times. A 2% solution of DBU in DMF (18 mL) was added, the vessel was shaken at room temperature for 15 minutes, and the reaction solution was removed by applying nitrogen pressure. Dehydrated NMP (30 mL) was added and the NMP was removed by applying nitrogen pressure. This operation was performed six times to give resin-loaded Compound aa052-b. 
     Dehydrated NMP (30 mL) was added thereto and the NMP was removed by applying nitrogen pressure. This operation was performed six times. A solution of NsCl (1.20 g, 5.42 mmol) in dehydrated NMP (30 mL), and collidine (1.8 mL, 13.6 mmol) were added and the vessel was shaken at 40° C. for one hour, after which the reaction solution was removed by applying nitrogen pressure. Dehydrated NMP (30 mL) was added and the NMP was removed by applying nitrogen pressure. This operation was performed six times to give resin-loaded Compound aa052-c. 
     Dehydrated DCM (30 mL) was placed thereinto and the vessel was shaken at room temperature for 15 minutes. The DCM was removed by applying nitrogen pressure, after which dehydrated DCM (25 mL) was added and the DCM was removed by applying nitrogen pressure. This operation was performed twice. Dehydrated THF (25 mL) was added and the THF was removed by applying nitrogen pressure. This operation was performed four times. A solution of triphenylphosphine (1.78 g, 6.78 mmol), DIAD (1.34 mL, 6.78 mmol), and 1-propanol (1.02 mL, 13.6 mmol) in THF (30 mL) was added, the vessel was shaken at 40° C. for 30 minutes, and the reaction solution was removed by applying nitrogen pressure. Dehydrated THF (25 mL) was added and the THF was removed by applying nitrogen pressure. This operation was performed four times. Dehydrated DCM (25 mL) was added and the DCM was removed by applying nitrogen pressure. This operation was performed four times to give resin-loaded Compound aa052-d. 
     Into a reaction vessel equipped with a filter were placed resin-loaded Compound aa052-d (600 mg, 0.271 mol, 0.452 mmol/g) and dehydrated DCM (6 mL), and the vessel was shaken at room temperature for 15 minutes. The DCM was removed by applying nitrogen pressure, after which dehydrated NMP (6 mL) was added and the NMP was removed by applying nitrogen pressure. This operation was performed four times. A mixture of dehydrated NMP and DBU (9/1, 2.4 mL) and a mixture of dehydrated NMP and dodecanethiol (3/1, 3 mL) were added, the vessel was shaken at room temperature for 1.5 hours, and the reaction solution was removed by applying nitrogen pressure. Dehydrated NMP (6 mL) was added and the NMP was removed by applying nitrogen pressure. This operation was performed four times. Dehydrated DCM (6 mL) was added and the DCM was removed by applying nitrogen pressure. This operation was performed four times to give resin-loaded Compound aa052. 
     A small amount of the resin-loaded Compound aa052 was cleaved from the resin with TFE/DCM (1/1), and the structure of the amino acid was confirmed by LC/MS. 
     LCMS (ESI) m/z=243 (M+H)+ 
     Retention time: 0.30 min (analysis condition SQDFA05) 
     Synthesis of Compound aa135-resin ((1R,2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)cyclohexane-1-carboxylic acid-2-chlorotrityl resin, Fmoc-2-ACHxC-O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
     
     Compound aa135-resin ((1R,2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)cyclohexane-1-carboxylic acid-2-chlorotrityl resin, Fmoc-2-ACHxC-O-Trt(2-Cl)resin) (4.38 g, loading amount 0.411 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using (1R,2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)cyclohexane-1-carboxylic acid (Fmoc-2-ACHxC-OH) purchased from a commercial supplier (1.12 g, 3.07 mmol) and 2-chlorotrityl chloride resin (1.60 mmol/g, 100-200 mesh, 1% DVB, 3.84 g, 6.14 mmol). 
     Synthesis of Compound aa136-resin ((1R,2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)cyclopentane-1-carboxylic acid-2-chlorotrityl resin (Fmoc-2-ACPnC-O-Trt(2-Cl)resin)) 
     
       
         
         
             
             
         
       
     
     Compound aa136-resin ((1R,2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)cyclopentane-1-carboxylic acid-2-chlorotrityl resin, Fmoc-2-ACPnC-O-Trt(2-Cl)resin) (1.65 g, loading amount 0.520 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using (1R,2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)cyclopentane-1-carboxylic acid (Fmoc-2-ACPnC-OH) purchased from a commercial supplier (0.411 g, 1.17 mmol) and 2-chlorotrityl chloride resin (1.60 mmol/g, 100-200 mesh, 1% DVB, 1.46 g, 2.34 mmol). 
     Synthesis of Compound aa137-resin, (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)hex-5-ynoic acid-2-chlorotrityl resin (Fmoc-D-(Propargyl)Gly-(C#CH2)—O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
     
     Compound aa137-resin ((3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)hex-5-ynoic acid-2-chlorotrityl resin, Fmoc-D-(Propargyl)Gly-(C#CH2)—O-Trt(2-Cl)resin) (4.18 g, loading amount 0.432 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)hex-5-ynoic acid (Fmoc-D-(Propargyl)Gly-(C#CH2)-OH) purchased from a commercial supplier (0.994 g, 2.85 mmol) and 2-chlorotrityl chloride resin (1.59 mmol/g, 100-200 mesh, 1% DVB, 3.58 g, 5.69 mmol). 
     Synthesis of Compound aa138-resin, (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid-2-chlorotrityl resin (Fmoc-D-3-Abu-O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
     
     Compound aa138-resin, (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid-2-chlorotrityl resin (Fmoc-D-3-Abu-O-Trt(2-Cl)resin) (33.44 g, loading amount 0.598 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid (Fmoc-D-3-Abu-OH) purchased from a commercial supplier (7.1 g, 21.82 mmol) and 2-chlorotrityl chloride resin (1.6 mmol/g, 100-200 mesh, 1% DVB, 27.25 g, 43.6 mmol). 
     Another lot synthesized in the same manner with a different loading amount was also used for peptide synthesis in the present Examples. 
     Synthesis of Compound aa139-resin, (3R)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]butanoic acid-2-chlorotrityl resin (Fmoc-D-3-MeAbu-O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
     
     Compound aa139-resin, (3R)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]butanoic acid-2-chlorotrityl resin (Fmoc-D-3-MeAbu-O-Trt(2-Cl)resin) (58.95 g, loading amount 0.536 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using (3R)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]butanoic acid (Fmoc-D-3-MeAbu-OH) purchased from a commercial supplier (11.5 g, 33.9 mmol) and 2-chlorotrityl chloride resin (1.69 mmol/g, 100-200 mesh, 1% DVB, 50 g, 84.5 mmol). 
     Another lot synthesized in the same manner with a different loading amount was also used for peptide synthesis in the present Examples. 
     Synthesis of Compound aa140-resin, (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)hex-5-enoic acid-2-chlorotrityl resin (Fmoc-D-Gly(Allyl)-(C#CH2)—O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
     
     Compound aa140-resin ((3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)hex-5-enoic acid-2-chlorotrityl resin, Fmoc-D-Gly(Allyl)-(C#CH2)—O-Trt(2-Cl)resin) (4.15 g, loading amount 0.420 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)hex-5-enoic acid (Fmoc-D-Gly(Allyl)-(C#CH2)-OH) purchased from a commercial supplier (1 g, 2.85 mmol) and 2-chlorotrityl chloride resin (1.59 mmol/g, 100-200 mesh, 1% DVB, 3.58 g, 5.69 mmol). 
     Synthesis of Compound aa141-resin, (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-methylhexanoic acid-2-chlorotrityl resin (Fmoc-D-Leu-(C#CH2)—O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
     
     To a mixture of diethyl ether (30 mL) and aqueous potassium hydroxide (50%, 12 mL) was added N-methyl-N-nitrosoacetamide (CAS No. 7417-67-6) (3.5 g, 29.5 mmol) at 0° C., and the mixture was stirred for 30 minutes. The diethyl ether layer was separated, and potassium hydroxide pellets were added to prepare a diazomethane solution. Two batches of the diazomethane solution on the same scale were further prepared and used for the next reaction. 
     Fmoc-D-Leu-OH (N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-leucine) (5 g, 14.15 mmol) was dissolved in toluene and the solvent was evaporated under reduced pressure. This operation was performed three times. The residue was dissolved in THF (40.4 mL) and cooled in a salt ice bath. N-Methylmorpholine (2.022 mL, 18.39 mmol) and ethyl chloroformate (1.766 mL, 18.39 mmol) were added dropwise thereto, respectively. After stirring in the salt ice bath for 20 minutes, the prepared diazomethane solution (28.3 mmol) was added at room temperature three times at 30-minutes intervals. The progress of the reaction was confirmed by LC/MS. The reaction solution was cooled to 0° C. and diluted with diethyl ether, after which a 10% aqueous citric acid solution was added and the mixture was extracted with diethyl ether. The organic layer was sequentially washed with a saturated aqueous sodium bicarbonate solution and brine and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give aa141-a (5 g, 13.24 mmol). 
     LCMS (ESI) m/z=378.3 (M+H)+ 
     Retention time: 0.89 min (analysis condition SQDFA05) 
     A solution of aa141-a (4 g, 10.59 mmol) in THF (42.4 mL) was cooled to 0° C., water (4.24 mL), silver trifluoroacetate (0.257 g, 1.165 mmol), and N-methylmorpholine (2.91 mL, 26.5 mmol) were added, and the mixture was stirred at room temperature. After confirming the completion of the reaction by LC/MS, the reaction solution was cooled to 0° C. and diluted with diethyl ether (40 mL). An aqueous citric acid solution (10%) was added to the mixture, which was extracted with ethyl acetate. The organic layer was washed with brine and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was triturated with hexane/ethyl acetate, and the solid was collected by filtration to give the target compound, aa141 ((3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-methylhexanoic acid, Fmoc-D-Leu-(C#CH2)-OH) (4 g, 82%). 
     LCMS (ESI) m/z=368.3 (M+H)+ 
     Retention time: 0.85 min (analysis condition SQDFA05) 
     Compound aa141-resin ((3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-methylhexanoic acid-2-chlorotrityl resin, Fmoc-D-Leu-(C#CH2)—O-Trt(2-Cl)resin) (4.1 g, loading amount 0.349 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using aa141 ((3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-methylhexanoic acid, Fmoc-D-Leu-(C#CH2)-OH) (1.045 g, 2.85 mmol) and 2-chlorotrityl chloride resin (1.59 mmol/g, 100-200 mesh, 1% DVB, 3.58 g, 5.69 mmol). 
     Synthesis of Compound aa143-resin, (R)-2-[1-(9H-fluoren-9-ylmethoxycarbonyl)piperidin-2-yl]acetic acid-2-chlorotrityl resin (Fmoc-D-Pic(2)-(C#CH2)—O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
     
     Compound aa143-resin, (R)-2-[1-(9H-fluoren-9-ylmethoxycarbonyl)piperidin-2-yl]acetic acid-2-chlorotrityl resin (Fmoc-D-Pic(2)-(C#CH2)—O-Trt(2-Cl)resin) (4.27 g, loading amount 0.347 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using (R)-2-[1-(9H-fluoren-9-ylmethoxycarbonyl)piperidin-2-yl]acetic acid (Fmoc-D-Pic(2)-(C#CH2)-OH) (1.01 g, 2.76 mmol) purchased from a commercial supplier and 2-chlorotrityl chloride resin (1.6 mmol/g, 100-200 mesh, 1% DVB, 3.84 g, 6.14 mmol). 
     Synthesis of Compound aa144-resin, 2-[(2R)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidin-2-yl]acetic acid-2-chlorotrityl resin (Fmoc-D-Pro-(C#CH2)—O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
     
     Compound aa144-resin (2-[(2R)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidin-2-yl]acetic acid-2-chlorotrityl resin, Fmoc-D-Pro-(C#CH2)—O-Trt(2-Cl)resin) (7.19 g, loading amount 0.377 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using 2-[(2R)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidin-2-yl]acetic acid (Fmoc-D-Pro-(C#CH2)-OH) (1 g, 2.85 mmol) purchased from a commercial supplier and 2-chlorotrityl chloride resin (1.6 mmol/g, 100-200 mesh, 1% DVB, 7 g, 21.39 mmol). 
     Synthesis of Compound aa107-resin, (3S)-4-[2-(tert-butylamino)-2-oxoethoxy]-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid-2-chlorotrityl resin (Fmoc-D-Ser(NtBu-Aca)-(C#CH2)—O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     To Compound aa107-a ((S)-β-(carbobenzoxyamino)-γ-butyrolactone) (15 g, 63.8 mmol) and palladium on carbon (5 g, 30 wt %) was added DMF (180 mL) under a nitrogen atmosphere, and the atmosphere was replaced with a hydrogen atmosphere. The reaction solution was stirred at room temperature for seven hours and filtered through celite. The celite was washed with DMF (25 mL) twice and the resulting residue was concentrated to give Compound aa107-b as a crude product (6.0 g, 93%). This was used for the next reaction without further purification. 
     The obtained Compound aa107-b (6.0 g, 59.3 mmol) was dissolved in DMF (170 mL) and cooled to 0° C. To the reaction solution was added triethylamine (24.8 mL, 178 mmol), after which a solution of trityl chloride (TrCl) (18.2 g, 65.3 mmol) in DMF (130 mL) was slowly added dropwise over 20 minutes. The reaction solution was warmed to room temperature and stirred at room temperature for 13 h. The reaction solution was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (n-hexane/ethyl acetate) to give Compound aa107-c (17 g, 83%). 
     LCMS (ESI) m/z=366 (M+Na)+ 
     Retention time: 0.65 min (analysis condition SQDAA50) 
     The obtained Compound aa107-c (20.8 g, 60.6 mmol) and sodium hydroxide (2.66 g, 66.6 mmol) were dissolved in a water/ethanol/THF solution (1.14 L, 1/5/5), the mixture was stirred at room temperature for one hour, and the reaction solution was concentrated under reduced pressure to give Compound aa107-d (23.9 g, quant.). 
     LCMS (ESI) m/z=384 (M+Na)+ 
     Retention time: 0.47 min (analysis condition SQDAA50) 
     The obtained Compound aa107-d (6 g, 15.7 mmol) was dissolved in DMF (50 mL) and cooled to 0° C. A solution of sodium tert-pentoxide (46.9 mmol) in toluene (14.8 mL) was added thereto, and the mixture was warmed to room temperature and stirred for 30 minutes. Next, a solution of 2-bromo-N-(tert-butyl)acetamide (CAS No. 57120-58-8) (4.56 g, 23.5 mmol) in DMF (15 mL) was added at 0° C. The reaction solution was warmed to room temperature and stirred for five hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by reverse phase column chromatography (10 mM aqueous ammonium acetate (AA)/methanol) to give Compound aa107-e (5.9 g, 79%). 
     LCMS (ESI) m/z=497 (M+Na)+ 
     Retention time: 0.60 min (analysis condition SQDAA50) 
     The obtained Compound aa107-e (5.0 g, 10.5 mmol) was dissolved in DCM/water (140 mL, 5/2), and 4 N aqueous hydrochloric acid/1,4-dioxane (42.1 mL, 169 mmol) was added. The reaction solution was stirred at room temperature for one hour, water (40 mL) was then added, and the mixture was washed with n-hexane (100 mL) twice. The resulting aqueous solution containing Compound aa107-f was used as such for the next reaction. 
     LCMS (ESI) m/z=233 (M+H)+ 
     Retention time: 0.27 min (analysis condition SQDFA05) 
     To the above aqueous solution of Compound aa107-f (ca. 90 mL) were added sodium carbonate (27.8 g, 263 mmol) and a solution of Fmoc-OSu (4.25 g, 12.6 mmol) in 1,4-dioxane (75 mL). The reaction solution was stirred at room temperature for two hours, after which TBME (300 mL) and 2 N aqueous hydrochloric acid (150 mL) were added. The organic layer was concentrated under reduced pressure, and the resulting residue was then purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa107 ((3S)-4-[2-(tert-butylamino)-2-oxoethoxy]-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid, Fmoc-D-Ser(NtBu-Aca)-(C#CH2)-OH) (2.3 g, 48.2% through two steps). 
     LCMS (ESI) m/z=455 (M+H)+ 
     Retention time: 0.75 min (analysis condition SQDFA05) 
     Compound aa107-resin ((3S)-4-[2-(tert-butylamino)-2-oxoethoxy]-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid-2-chlorotrityl resin, Fmoc-D-Ser(NtBu-Aca)-(C#CH2)—O-Trt(2-Cl)resin) (4 g, loading amount 0.279 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using Compound aa107 ((3S)-4-[2-(tert-butylamino)-2-oxoethoxy]-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid, Fmoc-D-Ser(NtBu-Aca)-(C#CH2)-OH) (1 g, 2.2 mmol) and 2-chlorotrityl chloride resin (1.6 mmol/g, 100-200 mesh, 1% DVB, 3.43 g, 5.5 mmol). 
     Synthesis of Compound aa108-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3-methylbutoxy)butanoic acid-2-chlorotrityl resin (Fmoc-D-Ser(iPen)-(C#CH2)—O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Compound aa107-d (6 g, 15.7 mmol) was dissolved in DMF (103 mL) and cooled to 0° C. To the reaction solution was added a solution of sodium tert-pentoxide (46.9 mmol) in toluene (14.1 mL), and the mixture was warmed to room temperature and stirred for 30 minutes. Next, 1-bromo-3-methyl-2-butene (2.71 mL, 23.5 mmol) was added at 0° C. The reaction solution was warmed to room temperature and stirred for four hours. 1-Bromo-3-methyl-2-butene (0.9 mL, 7.8 mmol) was further added and the mixture was stirred for four hours. Thereafter, the reaction solution was concentrated under reduced pressure, and the resulting residue was purified by reverse phase column chromatography (10 mM aqueous ammonium acetate/methanol) to give Compound aa108-a (3.4 g, 50.6%). 
     LCMS (ESI) m/z=428 (M−H)− 
     Retention time: 0.59 min (analysis condition SQDFA50) 
     Compound aa108-a (3.6 g, 8.38 mmol) and palladium on carbon (360 mg, 10 wt %) were mixed in methanol (41.9 mL), and then the mixture was stirred at room temperature for 20 hours under hydrogen atmosphere. To the reaction solution were added formic acid and DMSO, and the mixture was decanted with hexane (100 mL) and then concentrated under reduced pressure. The residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound aa108-b (600 mg, 38%). 
     LCMS (ESI) m/z=190 (M+H)+ 
     Retention time: 0.15 min (analysis condition SQDFA50) 
     The obtained Compound aa108-b (600 mg, 3.17 mmol) was dissolved in water (3.6 mL), DIPEA (2.49 mL, 14.3 mmol) was added, and Fmoc-OSu (1.07 g, 3.17 mmol) was added as a solution in 1,4-dioxane (4.75 mL). The reaction solution was stirred at room temperature for 30 minutes, water (4 mL) was then added, and the mixture was extracted with hexane/ether (3 mL, 3/1) twice. Potassium hydrogen sulfate (KHSO 4 ) (1.62 g, 14.3 mmol) was added to the aqueous layer, which was extracted with ethyl acetate (20 mL) twice. The combined organic layers were washed with brine/water (1/1, 15 mL) twice, dried over anhydrous sodium sulfate, and then filtered, and the filtrate was concentrated under reduced pressure to give Compound aa108 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3-methylbutoxy)butanoic acid, Fmoc-D-Ser(iPen)-(C#CH2)-OH) (1.2 g, 92%). 
     LCMS (ESI) m/z=412 (M+H)+ 
     Retention time: 0.91 min (analysis condition SQDFA05) 
     Compound aa108-resin ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3-methylbutoxy)butanoic acid-2-chlorotrityl resin, Fmoc-D-Ser(iPen)-(C#CH2)—O-Trt(2-Cl)resin) (434 mg, loading amount 0.415 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using Compound aa108 ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-(3-methylbutoxy)butanoic acid, Fmoc-D-Ser(iPen)-(C#CH2)-OH) (0.1 g, 0.243 mmol) and 2-chlorotrityl chloride resin (1.6 mmol/g, 100-200 mesh, 1% DVB, 0.380 g, 0.61 mmol). 
     Synthesis of Compound aa145-resin, 3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid-2-chlorotrityl resin (Fmoc-bMeAla-O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
     
     Compound aa145-resin (3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid-2-chlorotrityl resin, Fmoc-bMeAla-O-Trt(2-Cl)resin) (4.34 g, loading amount 0.449 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using 3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid (Fmoc-bMeAla-OH) (1 g, 3.07 mmol) purchased from a commercial supplier and 2-chlorotrityl chloride resin (1.6 mmol/g, 100-200 mesh, 1% DVB, 3.84 g, 6.15 mmol). 
     Synthesis of Compound aa146-resin, 3-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid-2-chlorotrityl resin (Fmoc-bAla-O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
     
     Compound aa146-resin (3-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid-2-chlorotrityl resin, Fmoc-bAla-O-Trt(2-Cl)resin) (37.86 g, loading amount 0.528 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using 3-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid (Fmoc-bAla-OH) (8 g, 25.7 mmol) purchased from a commercial supplier and 2-chlorotrityl chloride resin (1.6 mmol/g, 100-200 mesh, 1% DVB, 32.1 g, 51.4 mmol). 
     Synthesis of Compound aa147-resin, (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-phenylpentanoic acid-2-chlorotrityl resin (Fmoc-D-Hph-(C#CH2)—O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
     
     Compound aa147-resin ((3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-phenylpentanoic acid-2-chlorotrityl resin, Fmoc-D-Hph-(C#CH2)—O-Trt(2-Cl)resin) (3.61 g, loading amount 0.415 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-phenylpentanoic acid (Fmoc-D-Hph-(C#CH2)-OH) (1 g, 2.41 mmol) purchased from a commercial supplier and 2-chlorotrityl chloride resin (1.6 mmol/g, 100-200 mesh, 1% DVB, 3.03 g, 4.82 mmol). 
     Synthesis of Compound aa148-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4,4,4-trifluorobutanoic acid-2-chlorotrityl resin (Fmoc-3-CF3-bAla-(C#CH2)—O-Trt(2-Cl)resin) 
     
       
         
         
             
             
         
       
     
     Compound aa148-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4,4,4-trifluorobutanoic acid-2-chlorotrityl resin (Fmoc-3-CF3-bAla-(C#CH2)—O-Trt(2-Cl)resin) (2.19 g, loading amount 0.399 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4,4,4-trifluorobutanoic acid (Fmoc-3-CF3-bAla-(C#CH2)-OH) (0.569 mg, 1.5 mmol) purchased from a commercial supplier and 2-chlorotrityl chloride resin (1.59 mmol/g, 100-200 mesh, 1% DVB, 1.89 g, 3 mmol). 
     Synthesis of Compound aa149-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)resin)-pip) 
     
       
         
         
             
             
         
       
     
     Compound aa149-resin, (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)resin)-pip) was synthesized by the method described in WO 2013/100132 or WO 2018/225864. 
     Synthesis of Compound aa155-resin, 2-[(2R)-3-(dimethylamino)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-oxopropyl]sulfanylacetic acid-2-chlorotrityl resin 
     The amino acid was loaded onto the resin according to the following scheme. 
     
       
         
         
             
             
         
       
     
     Compound aa155-resin, 2-[(2R)-3-(dimethylamino)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-oxopropyl]sulfanylacetic acid-2-chlorotrityl resin (1.54 g, loading amount 0.336 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using Compound aa155 (2-[(2R)-3-(dimethylamino)-2-[19H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-oxopropyl]sulfanylacetic acid) (0.46 g, 1.04 mmol) and 2-chlorotrityl chloride resin (1.6 mmol/g, 100-200 mesh, 1% DVB, 1.3 g, 2.08 mmol). 
     1-3. Peptide Solid-Phase Synthesis by an Automated Synthesizer 
     Cyclic peptide compounds (Compounds 1-762, 764-845, 847-1027, 1029-1146, 1148-1410, 1412-2020, 2111, 2143-2151, and 2172-2179) (Table 24) were synthesized by the method described in WO 2013/100132 or WO 2018/225864. Peptides were synthesized by the Fmoc method detailed below using a peptide synthesizer (Multipep RS; manufactured by Intavis). The detailed operational procedure was according to the manual appended to the synthesizer. The relationship between formal names, structures, and abbreviations of the respective amino acid residues constituting cyclic peptides described in Table 24 will be understood from Tables 2 to 7 above and Table 8 below. 
     
       
         
           
               
               
               
             
               
                 TABLE 8 
               
               
                   
               
               
                 Abbreviation 
                 Amino acid structural formula 
                 Name 
               
               
                   
               
             
            
               
                 MeGln(Aze-3-F2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-5-(3,3-difluoroazetidin-1- yl)-2-(methylamino)-5-oxo- pentanoic acid 
               
               
                   
               
               
                 (MeOMeallyl)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[[(E)-4-methoxybut-2-enyl]- amino]acetic acid 
               
               
                   
               
               
                 (DMAOEt)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[2-[2-(dimethylamino)-2- oxo-ethoxy]ethylamino]acetic acid 
               
               
                   
               
               
                 (HOtBuOEt)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[2-(2-hydroxy-2-methyl- propoxy)ethylamino]acetic acid 
               
               
                   
               
               
                 (HOtBuallyl)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[[(E)-5-hydroxy-5-methyl- hex-2-enyl]amino]acetic acid 
               
               
                   
               
               
                 (Me2NCOnPr)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[[4-(dimethylamino)-4-oxo- butyl]amino]acetic acid 
               
               
                   
               
               
                 (5-OH—nPent)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(5-hydroxypentylamino)- acetic acid 
               
               
                   
               
               
                 (HOEtallyl)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[[(E)-5-hydroxypent-2-enyl]- amino]acetic acid 
               
               
                   
               
               
                 (DMFallyl)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[[(E)-4-(dimethylamino)-4- oxo-but-2-enyl]amino]acetic acid 
               
               
                   
               
               
                 (HOiPrallyl)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[[(E)-4-hydroxy-4-methyl- pent-2-enyl]amino]acetic acid 
               
               
                   
               
               
                 Hph(24-F2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(2,4-difluoro- phenyl)butanoic acid 
               
               
                   
               
               
                 (HOEt)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(2-hydroxyethylamino]acetic acid 
               
               
                   
               
               
                 (3-pyr-Me)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(3-pyridylmethylamino)- acetic acid 
               
               
                   
               
               
                 (4-pyr-Me)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(4-pyridylmethylamino)- acetic acid 
               
               
                   
               
               
                 (3-pyr-Et)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[2-(3-pyridyl)ethylamino]- acetic acid 
               
               
                   
               
               
                 (4-pyr-Et)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[2-(4-pyridyl)ethylamino]- acetic acid 
               
               
                   
               
               
                 (Et(2-F3)OEt)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[2-(2,2,2-trifluoroethoxy)- ethylamino]acetic acid 
               
               
                   
               
               
                 (MeOEtOEt)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[2-(2-methoxyethoxy)ethyl- amino]acetic acid 
               
               
                   
               
               
                 (Et(2-F2)OEt)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[2-(2,2-difluoroethoxy)ethyl- amino]acetic acid 
               
               
                   
               
               
                 (pip(4-F2)Et)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[2-(4,4-difluoro-1-piperidyl)- ethylamino]acetic acid 
               
               
                   
               
               
                 MeAbu(BocAze) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-4-(1-tert-butoxycarbonyl- ylazetidin-3-yl)-2-(methyl- amino)butanoic acid 
               
               
                   
               
               
                 Hph(2-F—4-Cl) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(4-chloro-2- fluoro-phenyl)butanoic acid 
               
               
                   
               
               
                 MeAbu(BocAzedene) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-4-(1-tert-butoxycarbonyl- azetidin-3-ylidene)-2-(methyl- amino)butanoic acid 
               
               
                   
               
               
                 MeAbu(THP) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(methylamino)-4-tetra- hydropyran-4-yl-butanoic acid 
               
               
                   
               
               
                 MeAbu(THPdene) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(methylamino)-4-tetra- hydropyran-4-ylidene-butanoic acid 
               
               
                   
               
               
                 (OxecBu)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(2-oxaspiro[3.3]heptan-6-yl- amino)acetic acid 
               
               
                   
               
               
                 (OxeMe)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(oxetan-3-ylmethylamino)- acetic acid 
               
               
                   
               
               
                 (F2cBucBu)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-[(2,2-difluorospiro[3.3]- heptan-6-yl)amino]acetic acid 
               
               
                   
               
               
                 (Ph-4-Cl)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(4-chloroanilino)acetic acid 
               
               
                   
               
               
                 (Ph-3-Cl)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(3-chloroanilino)acetic acid 
               
               
                   
               
               
                 (3-Thienyl)Gly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(3-thienylamino)acetic acid 
               
               
                   
               
               
                 Hyp(2-EtOH) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-(2-hydroxyethoxy)- pyrrolidine-2-carboxylic acid 
               
               
                   
               
               
                 cisHyp(2-EtOH) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S ; 4S)-4-(2-hydroxyethoxy)- pyrrolidine-2-carboxylic acid 
               
               
                   
               
               
                 Hph(2-F—5-Cl) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(5-chloro-2- fluorophenyl)butanoic acid 
               
               
                   
               
               
                 PhGly 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-anilinoacetic acid 
               
               
                   
               
               
                 Hyp(3-thie-Me) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-(3-thienylmethoxy)- pyrrolidine-2-carboxylic acid 
               
               
                   
               
               
                 Ser(Ph) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-3-phenoxy- propanoic acid 
               
               
                   
               
               
                 Pro(4S-Tri) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-4-(triazol-1-yl)- pyrrolidine-2-carboxylic acid 
               
               
                   
               
               
                 Pro(4R-Tri) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-(triazol-1-yl)- pyrrolidine-2-carboxylic acid 
               
               
                   
               
               
                 cisPro(4-pip-4-F2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-4-(4,4-difluoro-1- piperidyl)pyrrolidine-2- carboxylic acid 
               
               
                   
               
               
                 Hyp(Et(2-F2)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-(2,2-difluoro- ethoxy)pyrrolidine-2-carbox- ylic acid 
               
               
                   
               
               
                 cisHyp(Et(2-F2)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-4-(2,2-difluoro ethoxy)-pyrrolidine-2-carbox- ylic acid 
               
               
                   
               
               
                 cisHyp(3-Me-Pyr) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S : 4S)-4-(3-pyridylmethoxy)- pyrrolidine-2-carboxylic acid 
               
               
                   
               
               
                 Hyp(3-Me-Pyr) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-(3-pyridylmethoxy)- pyrrolidine-2-carboxylic acid 
               
               
                   
               
               
                 MeAla(3-Pyr-4-CN) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(6-cyano-3-pyridyl)-2- (methylamino)propanoic acid 
               
               
                   
               
               
                 MeTyr(3-F) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(3-fluoro-4-hydroxy- phenyl)-2-(methylamino)- propanoic acid 
               
               
                   
               
               
                 cisHyp(Bzl(4-OCHF2)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-4-[[4-(difluorometh- oxy)phenyl]methoxy]pyrrol- idine-2-carboxylic acid 
               
               
                   
               
               
                 cisHyp(Bzl(4-Me)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-4-(p-tolylmethoxy)- pyrrolidine-2-carboxylic acid 
               
               
                   
               
               
                 cisHyp(Bzl(3-OMe)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-4-[(3-methoxyphen- yl)methoxy]pyrrolidine-2- carboxylic acid 
               
               
                   
               
               
                 cisHyp(Bzl(3-Me)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S : 4S)-4-(m-tolylmethoxy)- pyrrolidine-2-carboxylic acid 
               
               
                   
               
               
                 cisHyp(Bzl(2-Me)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-4-(o-tolylmethoxy)- pyrrolidine-2-carboxylic acid 
               
               
                   
               
               
                 Hyp(Bzl(4-OCHF2)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-[[4-(difluorometh- oxy)phenyl]methoxy]pyrrol- idine-2-carboxylic acid 
               
               
                   
               
               
                 Hyp(Bzl(4-Me)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S4R)-4-(p-tolylmethoxy)- pyrrolidine-2-carboxylic acid 
               
               
                   
               
               
                 Hph(245-F3) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(2,4,5- trifluorophenyl)butanoic acid 
               
               
                   
               
               
                 Hyp(Bzl(3-OMe)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-[(3-methoxyphen- yl)methoxy]pyrrolidine-2- carboxylic acid 
               
               
                   
               
               
                 Hyp(Bzl(3-Me)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S : 4R)-4-(m-tolylmethoxy)- pyrrolidine-2-carboxylic acid 
               
               
                   
               
               
                 Hyp(Bzl(2-Me)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-(o-tolylmethoxy)- pyrrolidine-2-carboxylic acid 
               
               
                   
               
               
                 Hyp(Bzl(4-Cl)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-[(4-chlorophenyl)- methoxy]pyrrolidine-2-carbox- ylic acid 
               
               
                   
               
               
                 Hyp(Bzl(3-Cl)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-[(3-chlorophenyl)- methoxy]pyrrolidine-2-carbox- ylic acid 
               
               
                   
               
               
                 cisHyp(Bzl(4-Cl)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-4-[(4-chlorophenyl)- methoxy]pyrrolidine-2-carbox- ylic acid 
               
               
                   
               
               
                 cisHyp(Bzl(3-Cl)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S, ; 4S)-4-[(3-chlorophenyl)- methoxy]pyrrolidine-2-carbox- ylic acid 
               
               
                   
               
               
                 cisHyp(Bzl(2-Cl)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-4-[(2-chlorophenyl)- methoxy]pyrrolidine-2-carbox- ylic acid 
               
               
                   
               
               
                 Hyp(Bzl(2-Cl)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-[(2-chlorophenyl)- methoxy]pyrrolidine-2-carbox- ylic acid 
               
               
                   
               
               
                 cisHyp(Et) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-4-ethoxypyrrolidine- 2-carboxylic acid 
               
               
                   
               
               
                 Hph(F5) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(2,3,4,5,6- pentafluorophenyl)butanoic acid 
               
               
                   
               
               
                 Hyp(Bzl) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-benzyloxypyrrol- idine-2-carboxylic acid 
               
               
                   
               
               
                 cisHyp 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4S)-4-hydroxypyrrol- idine-2-carboxylic acid 
               
               
                   
               
               
                 Hyp 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S,4R)-4-hydroxypyrrol- idine-2-carboxylic acid 
               
               
                   
               
               
                 Ser(tBuOH) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-3-(2-hydroxy- 2-methyl-propoxy)propanoic acid 
               
               
                   
               
               
                 Ser(Bn-2-Cl) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-3-[(2-chloro- phenyl)methoxy]propanoic acid 
               
               
                   
               
               
                 Ser(Bn-3-Cl) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-3-[(3-chloro- phenyl)methoxy]propanoic acid 
               
               
                   
               
               
                 Ser(Ph-4-Cl) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-3-(4-chloro- phenoxy)propanoic acid 
               
               
                   
               
               
                 Hse(Ph-4-CF3) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-[4-(trifluoro- methyl)phenoxy]butanoic acid 
               
               
                   
               
               
                 Hse(Ph-34-Cl2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(3,4-dichloro- phenoxy)butanoic acid 
               
               
                   
               
               
                 Hse(Ph-4-Cl) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(4-chloro- phenoxy)butanoic acid 
               
               
                   
               
               
                 Hph(4-CF3—2-F) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-[2-fluoro-4- (trifluoromethyl)phenyl]- butanoic acid 
               
               
                   
               
               
                 Ser(Bn-4-Cl) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-3-[(4-chloro- phenyl)methoxy]propanoic acid 
               
               
                   
               
               
                 Phe3(4-CF3) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-5-[4-(trifluoro- methyl)phenyl]pentanoic acid 
               
               
                   
               
               
                 Hph(34-Cl2—5-OtBu) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(3-tert-butoxy- 4,5-dichloro-phenyl)butanoic acid 
               
               
                   
               
               
                 Hph(34-Cl2—5-OnBu) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(3-butoxy- 4,5-dichloro-phenyl)butanoic acid 
               
               
                   
               
               
                 Hph(34-Cl2—5-OiPr) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(3,4-dichloro- 5-isopropoxy-phenyl)butanoic acid 
               
               
                   
               
               
                 Hph(34-Cl2—5-CN) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(3,4-dichloro- 5-cyano-phenyl)butanoic acid 
               
               
                   
               
               
                 Hph(34-Cl2—5-OMe) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(3,4-dichloro- 5-methoxy-phenyl)butanoic acid 
               
               
                   
               
               
                 Hph(345-Cl3) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(3,4,5-tri- chlorophenyl)butanoic acid 
               
               
                   
               
               
                 Abu(7-Quino) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(7-quinolyl)- butanoic acid 
               
               
                   
               
               
                 Hph(3-F—4-CHF2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-[4-(difluoro- methyl)-3-fluoro-phenyl]- butanoic acid 
               
               
                   
               
               
                 MeAsp-pip(4-CF2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-4-(4,4-difluoro-1-piperi- dyl)-3-(methylamino)-4-oxo- butanoic acid 
               
               
                   
               
               
                 Hph(4-SO2Me) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(4-methyl- sulfonylphenyl)butanoic acid 
               
               
                   
               
               
                 Abu(2-Pyr-4-CF3) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-[5-(trifluoro- methyl)-2-pyridyl]butanoic acid 
               
               
                   
               
               
                 Abu(3-Pyr-4-CHF2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-[6-(difluoro- methyl)-3-pyridyl]butanoic acid 
               
               
                   
               
               
                 Abu(5-Bzfr) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(benzofuran- 5-yl)butanoic acid 
               
               
                   
               
               
                 Abu(3-Pyr-4-OMe) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(6-methoxy- 3-pyridyl)butanoic acid 
               
               
                   
               
               
                 Abu(1-Me-5-Indo) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(1-methyl- indol-5-yl)butanoic acid 
               
               
                   
               
               
                 Abu(1-Me-6-Indo) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(1-methyl- indol-6-yl)butanoic acid 
               
               
                   
               
               
                 Abu(6-Quino) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(6-quinolyl)- butanoic acid 
               
               
                   
               
               
                 Hph(3-F—4-OCF3) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-[3-fluoro-4- (trifluoromethoxy)phenyl]- butanoic acid 
               
               
                   
               
               
                 Hph(3-Cl—4-OCF3) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-[3-chloro-4- (trifluoromethoxy)phenyl]- butanoic acid 
               
               
                   
               
               
                 MeAsp-pip(3-F2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (3S)-4-(3,3-difluoro-1- piperidyl)-3-(methylamino)- 4-oxo-butanoic acid 
               
               
                   
               
               
                 Abu(34-Cate(CF2)) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(2,2-difluoro- 1,3-benzodioxol-5-yl)butanoic acid 
               
               
                   
               
               
                 Abu(3-Pyr-4-CF3) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-[6-(trifluoro- methyl)-3-pyridyl]butanoic acid 
               
               
                   
               
               
                 Hph(3-OMe—4-CF3) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-[3-methoxy- 4-(trifluoromethyl)phenyl]- butanoic acid 
               
               
                   
               
               
                 Hph(3-CN—4-CF3) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-[3-cyano-4- (trifluoromethyl)phenyl]- butanoic acid 
               
               
                   
               
               
                 Hph(3-F—4-OCHF2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-[4-(difluoro- methoxy)-3-fluoro-phenyl]- butanoic acid 
               
               
                   
               
               
                 Phe(3-C#C) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-3-(3-ethynyl- phenyl)propanoic acid 
               
               
                   
               
               
                 Phe(3-Cl—4-F) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-3-(3-chloro-4- fluoro-phenyl)propanoic acid 
               
               
                   
               
               
                 Hph(3-CF3) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-[3-(trifluoro- methyl)phenyl]butanoic acid 
               
               
                   
               
               
                 1-ACPrC 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1-aminocyclopropanecarbox- ylic acid 
               
               
                   
               
               
                 cHex 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1-aminocyclohexanecarbox- ylic acid 
               
               
                   
               
               
                 Hph(246-F3) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(2,4,6- trifluorophenyl)butanoic acid 
               
               
                   
               
               
                 EtPhe(2-Cl) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(2-chlorophenyl)-2- (ethylamino)propanoic acid 
               
               
                   
               
               
                 MeAsn(mor) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(methylamino)-4- morpholino-4-oxo-butanoic acid 
               
               
                   
               
               
                 MeAsn(pyrro) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(methylamino)-4-oxo- 4-pyrrolidin-1-yl-butanoic acid 
               
               
                   
               
               
                 MeAsn(pip) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(methylamino)-4-oxo- 4-(1-piperidyl)butanoic acid 
               
               
                   
               
               
                 MeAsn(Aze) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-4-(azetidin-1-yl)-2-(meth- ylamino)-4-oxo-butanoic acid 
               
               
                   
               
               
                 MeAsn(Me2) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-4-(dimethylamino)-2- (methylamino)-4-oxo-butanoic acid 
               
               
                   
               
               
                 MeGln(mor) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(methylamino)-5- morpholino-5-oxo-pentanoic acid 
               
               
                   
               
               
                 MeGln(pyrro) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(methylamino)-5-oxo- 5-pyrrolidin-1-yl-pentanoic acid 
               
               
                   
               
               
                 MeGln(pip) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-(methylamino)-5-oxo- 5-(1-piperidyl)pentanoic acid 
               
               
                   
               
               
                 MeGln(Aze) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-5-(azetidin-1-yl)-2-(meth- ylamino)-5-oxo-pentanoic acid 
               
               
                   
               
               
                 Hph(2-F—6-Cl) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-2-amino-4-(2-chloro-6- fluoro-phenyl)butanoic acid 
               
               
                   
               
               
                 MeSer(tBuOH) 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2S)-3-(2-hydroxy-2-methyl- propoxy)-2-(methylamino)- propanoic acid 
               
               
                   
               
            
           
         
       
     
     The peptide synthesis method by the Fmoc method (the basic peptide synthesis method) is described in detail in the following 1-3-1 to 1-3-5. 
     1-3-1. Peptide elongation reaction by the Fmoc method from the N-terminus of an amino acid Peptide compounds were synthesized by a solid-phase synthesis method using Fmoc-protected amino acids on a peptide synthesizer (Multipep RS or Multipep RSi) manufactured by Intavis. Specific procedures for the operation were performed according to the instructions attached to the synthesizer. 
     Fmoc-protected amino acids (0.3-0.6 mol/L) constituting the target peptide, and HOAt, oxyma, or HOOBt (0.375 mol/L) serving as a carboxyl group activator were dissolved in NMP or NMP/DMF (1/1) to prepare Solution 1. When the Fmoc-protected amino acids were poorly soluble in the above-mentioned solvents, DMSO was added at 20% to 30% (v/v) to prepare Solution 1. When using, for example, Fmoc-MeSer(tBuOTHP)-OH, Fmoc-Ser(tBuOTHP)—OH, Fmoc-MeSer(THP)—OH, Fmoc-Thr(THP)—OH, Fmoc-Ser(THP)—OH, Fmoc-cisHyp(THP)—OH (Compound aa101), or Fmoc-Hyp(THP)—OH (Compound aa102) as an Fmoc-protected amino acid having a THP protecting group on the side chain, oxyma was used as the carboxyl group activator to prepare Solution 1, and Molecular Sieves 4A 1/8 (Wako Pure Chemical Industries) or Molecular Sieves 4A 1/16 (Wako Pure Chemical Industries) were added thereto, and the solution was used for peptide synthesis. N,N′-Diisopropylcarbodiimide (DIC) (10% v/v) and N,N-dimethylformamide (DMF) were mixed to prepare Solution 2. 
     2-Chlorotritylresin (100 mg) to which was attached the carboxylic acid at the side chain of an aspartic acid with the N-terminus protected by Fmoc group or the main chain carboxylic acid site of an amino acid with the N-terminus protected by Fmoc group was added to a solid-phase reaction vessel and the vessel was placed into the peptide synthesizer. Dichloromethane (DCM) (0.8 mL) was added to this resin (100 mg), and the resin was swollen by allowing to stand for one hour. Subsequently, the solution was removed from the frit. Solution 1 and Solution 2 were placed in the peptide synthesizer, and automated synthesis by the peptide synthesizer was started. 
     A solution of diazabicycloundecene (DBU) in DMF (2% v/v, 0.7 mL) was added to a resin-containing solid-phase reaction vessel to deprotect the N-terminal Fmoc group at room temperature. For deprotection of the first residue, the reaction was carried out for 4.5 minutes, and for deprotection of the second or subsequent residue, the reaction was carried out for 10 minutes, after which the solution was removed from the frit. DMF (0.7 mL) was added thereto, and after allowing to stand for 5 minutes, the solution was removed from the frit. Repeating this resin washing step three more times gave the resin onto which was attached the amino acid or peptide having an amino group at the N-terminus by removing the Fmoc group. 
     Next, Solution 1 (0.3 mL) and Solution 2 (0.36 mL) were mixed in a mixing vial of the synthesizer, and then added to the above-mentioned deprotected resin, and the solid-phase reaction vessel was warmed to 40° C. For sequences that elongated poorly, and such, the vessel was warmed to reach 60° C. as necessary. Condensation reaction between the amino group on the resin and the Fmoc-protected amino acid was carried out for 2.5 hours. For sequences that elongated poorly, and such, the reaction was carried out for 20 hours. After the reaction, the solution was removed from the frit. When the elongation efficiency was low, this condensation reaction with the Fmoc-protected amino acid was further repeated once or twice. Next, the resin was washed three times with DMF (0.7 mL). This Fmoc amino acid condensation reaction following the Fmoc deprotection reaction was defined as one cycle, and by repeating this cycle, the peptide was elongated on the resin surface. After completion of the peptide elongation, a solution of diazabicycloundecene (DBU) in DMF (2% v/v, 0.7 mL) was added to the resin, this was allowed to react for 15 minutes to carry out the Fmoc deprotection reaction, and then the solution was removed from the frit. The resulting resin was washed four times with DMF (0.7 mL), and four times with DCM (0.7 mL). 
     1-3-2. Cleavage of the Elongated Peptide from the Resin 
     To the resin obtained by methods described in WO2013/100132 and WO2018/225864, or by the above-mentioned method, 2,2,2-trifluoroethanol (TFE)/DCM (1/1, v/v, 2 mL) containing 0.75% (v/v) DIPEA was added, followed by the reaction at room temperature for two hours. Then, the reaction to cleave the peptide chain from the resin was carried out. After the reaction, the solution in the tube was recovered from the frit. The operation of adding 2,2,2-trifluoroethanol (TFE)/DCM (1/1, v/v, 1 mL) to the remaining resin and recovering the solution from the frit was performed twice. All the resulting cleavage solutions were combined, DMF (4 mL) or 1,2-dichloroethane (4 mL) were mixed therein, and then the solvent was evaporated under reduced pressure by a high throughput centrifugal evaporator (HT-12) manufactured by Genevac. 
     1-3-3. Method of Cyclizing the Cleaved Peptide 
     The residue obtained by the above-mentioned method was dissolved in a mixture of DMF (4 mL) and DCM (4 mL). To the mixture were added a solution of (1-cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino-mopholino-carbeniumhexafluorophosphate (COMU) in DMF (0.5 M, 1.5 equivalents) or a solution of O-(7-aza-1H-benzotriazol-1-yl)-N,N,N,N,-tetramethyluroniumhexafluorophosphate (HATU) in DMF (0.5 M, 1.5 equivalents), and DIPEA (1.8 equivalents), and by stirring this mixture at room temperature for two hours, a cyclocondensation reaction between the N-terminal amino group and the C-terminal carboxyl group was carried out. The number of equivalents was calculated based on the value obtained by multiplying the amount of resin used (normally 100 mg) to the amino acid loading rate (mmol/g) of the resin used as a raw material. After confirming the production of the target cyclic peptide by LC/MS measurement (SQ Detector 2, manufactured by Waters), the solvent was evaporated from the reaction solution under reduced pressure by a high throughput centrifugal evaporator (HT-12) manufactured by Genevac. 
     1-3-4. Deprotection of the Protecting Group for the Side Chain Functional Group Possessed by the Cyclic Peptide 
     For the sequences synthesized using an Fmoc-protected amino acid having a THP-protected hydroxyl group on the side chain, for example, Fmoc-MeSer(tBuOTHP)—OH, Fmoc-Ser(tBuOTHP)—OH, Fmoc-MeSer(THP)—OH, Fmoc-Thr(THP)—OH, Fmoc-Ser(THP)—OH, Fmoc-D-MeSer(THP)—OH (Compound aa054), Fmoc-cisHyp(THP)—OH (Compound aa101), or Fmoc-Hyp(THP)—OH (Compound aa102), 4 mL of a solution of tetramethylammonium hydrogensulfate (0.05 M) in 1,1,1,3,3,3-hexafluoroisopropyl alcohol (HFIP) (containing 2% (v/v) triisopropylsilane (TIPS) and 1% (v/v) 1,2-dichloroethane) was added to the above-obtained residue, and the residue was dissolved, after which the THP protecting group was deprotected by allowing to stand at room temperature for four hours. After confirming the completion of the reaction by LC/MS (SQ Detector 2 manufactured by Waters), diisopropylethylamine (DIPEA) (70 μL) was added and the solvent was evaporated under reduced pressure by a high throughput centrifugal evaporator (HT-12) manufactured by Genevac. In this deprotection reaction, another fluoroalcohol such as 2,2,2-trifluoroethanol (TFE) may also be used instead of HFIP. 
     For the sequences synthesized using Fmoc-MeAsp(OAl)—OH, cyclic peptides were dissolved in DMF (0.5 M), tetrakis(triphenylphosphine)palladium (0) (0.01-0.05 equivalents relative to the peptide) and phenylsilane (0.7 equivalents relative to the peptide) were added at room temperature under a nitrogen atmosphere, and the allyl group was deprotected by stirring for 30 minutes. Production of the target cyclic peptide was confirmed by LC/MS measurements (SQ Detector 2 manufactured by Waters), and then the solvent was evaporated from the reaction solution under reduced pressure by a high throughput centrifugal evaporator (HT-12) manufactured by Genevac. 
     1-3-5. Method of Purifying the Cyclic Peptides 
     DMF or DMSO was added to the residue obtained by the above-mentioned method, insoluble substances were removed by filtration, and then purification by preparative HPLC was carried out to give the target cyclic peptide. Waters Auto Purification System was used for the purification instrument, YMC-Actus Triart C18 (internal diameter of 20 mm, length of 100 mm) or YMC-Actus Triart Phenyl (internal diameter of 20 mm, length of 100 mm) was used as the column, and methanol-aqueous ammonium acetate solution (50 mmol/L) or acetonitrile-water containing 0.1% formic acid was used as the mobile phase. 
     Synthesis of Compound 1 
     The target Compound 1 (16.6 mg, 23%) was obtained using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (0.478 mmol/g, 100 mg, 0.0478 mmol) as a raw material, and using Fmoc-MeChg-OH, Fmoc-cLeu-OH, Fmoc-Pro-OH, Fmoc-Hph(4-CF3-3-Cl)—OH, Fmoc-MeGly-OH, Fmoc-MeCha-OH, Fmoc-MeGly-OH, Fmoc-MeGly-OH, Fmoc-Cha-OH, and Fmoc-MeLeu-OH, by performing the above-described peptide elongation reaction by the Fmoc method, cleavage of the elongated peptide from the resin, cyclization of the cleaved peptide (using O-(7-aza-1H-benzotriazol-1-yl)-N,N,N,N,-tetramethyluroniumhexafluorophosphate (HATU) as the cyclizing agent), and purification of the cyclic peptide. 
     Compound 1 ((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9,18-bis(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     
       
         
         
             
             
         
       
     
     LCMS (ESI) m/z=1480.1 (M−H)− 
     Retention time: 2.155 min (analysis condition SSC-FA-03) 
     Compounds 2 to 762, Compounds 764 to 845, Compounds 847 to 1027, Compounds 1029 to 1135, Compounds 2007 to 2020, and Compound 2111 were produced based on the method for producing Compound 1. Compounds 1373 to 1376 were produced by performing an additional deprotection reaction to the cyclic peptide compounds produced based on the method for producing Compound 1. Compounds 1450 to 1460 were produced by a method based on the method for producing Compound 1 which additionally includes repeating the step of condensing an βα-disubstituted amino acid with an N-alkyl amino acid multiple times. 
     Synthesis of Compound 1355 
     The target Compound 1355 (9.75 mg, 24%) was obtained using Compound aa010-resin, (3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-oxobutanoic acid-2-chlorotrityl resin (Fmoc-MeAsp(O-Trt(2-Cl)resin)-Mor(26-bicyc)) (0.279 mmol/g, 100 mg, 0.0279 mmol) as a raw material, and using Fmoc-MeGly(cPent)-OH, Fmoc-cLeu-OH, Fmoc-Pro-OH, Fmoc-Hph(4-CF3-35-F2)-OH, Fmoc-MeGly-OH, Fmoc-MeSer(nPr)—OH, Fmoc-Aze(2)-OH, Fmoc-MeAla-OH, Fmoc-Ile-OH, and Fmoc-MeLeu-OH, by performing the above-described peptide elongation reaction by the Fmoc method, cleavage of the elongated peptide from the resin, cyclization of the cleaved peptide (using (1-cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino-mopholino-carbeniumhexafluorophosphate (COMU) as the cyclizing agent), and purification of the cyclic peptide. 
     Compound 1355 ((5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-15-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-8-((S)-sec-butyl)-18-cyclopentyl-29-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-35-(propoxymethyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1′-cyclopentan]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecaone) 
     
       
         
         
             
             
         
       
     
     LCMS (ESI) m/z=1457.9 (M−H)− 
     Retention time: 7.425 min (analysis condition SSC-A-AF-01) 
     Compounds 1136 to 1146, Compounds 1148 to 1354, and Compounds 1356 to 1372 were produced based on the method for producing Compound 1355. Compounds 1869 to 2006 were produced by a method based on the method for producing Compound 1355 which additionally includes the step of condensing a sequence comprising an αα-disubstituted amino acid and/or N-alkyl amino acid by heating at 40° C. to 60° C. 
     Synthesis of Compound 1471 
     The target Compound 1471 (12.68 mg, 19%) was obtained using Compound aa138-resin, (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid-2-chlorotrityl resin (Fmoc-D-3-Abu-O-Trt(2-Cl)resin) (0.494 mmol/g, 100 mg, 0.0494 mmol) as a raw material, and using Fmoc-MeGly(cPent)-OH, Fmoc-cLeu-OH, Fmoc-Pro-OH, Fmoc-Hph(4-CF3-3-Cl)—OH, Fmoc-MeGly-OH, Fmoc-MePhe(4-Me)-OH, Fmoc-MeGly-OH, Fmoc-MeGly-OH, Fmoc-Ile-OH, and Fmoc-MeLeu-OH, by performing the above-described peptide elongation reaction by the Fmoc method (for the elongation with Fmoc-cLeu-OH, Oxyma was used as the condensing agent, and after the reaction, disposal of the solution from the frit was followed by further condensation reaction with Fmoc-cLeu-OH which was repeated twice. Furthermore, the unreacted amino groups were capped using Z-Gly-OH (CAS No. 1138-80-3), HOAt and DIC as condensing agents, and DMF as solvent. The treatment step for unreacted amino groups is also called a removal step by glycine capping), cleavage of the elongated peptide from the resin, cyclization of the cleaved peptide (using O-(7-aza-1H-benzotriazol-1-yl)-N,N,N,N,-tetramethyluroniumhexafluorophosphate (HATU) as the cyclizing agent), and purification of the cyclic peptide. 
     Compound 1471 ((3S,9S,18S,21S,25R,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclopentyl-21-isobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]-9-(p-tolylmethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     
       
         
         
             
             
         
       
     
     LCMS (ESI) m/z=1322.9 (M−H)− 
     Retention time: 2.149 min (analysis condition SSC-AF-00) 
     Based on the method for producing Compound 1471, Compounds 1377 to 1410, Compounds 1412 to 1449, Compounds 1461 to 1470, and Compounds 1472 to 1643 were produced by a method based on the method for producing Compound 1471 which additionally includes performing the step of condensing a sequence comprising an αα-disubstituted amino acid and/or N-alkyl amino acid by repeating the step multiple times or by heating at 40° C. to 60° C., or by combining the repetition and heating. 
     Synthesis of Compound 1805 
     The target Compound 1805 (25.53 mg, 38%) was obtained by using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (0.478 mmol/g, 100 mg, 0.0478 mmol) as a raw material, and using Fmoc-MeChg-OH, Fmoc-cLeu-OH, Fmoc-Pro-OH, Fmoc-Hph(4-CF3-3-Cl)—OH, Fmoc-MeGly-OH, Fmoc-MeSer(nPr)—OH, Fmoc-MeGly-OH, Fmoc-MeGly-OH, Fmoc-Ile-OH, and Fmoc-MeLeu-OH, by performing the above-described peptide elongation reaction by the Fmoc method (Fmoc-MeChg-OH was subjected to a condensation reaction using Oxyma as the condensing agent at 50° C. for ten hours, and Fmoc-cLeu-OH was subjected to a condensation reaction using Oxyma as the condensing agent at 60° C. for 16 hours), cleavage of the elongated peptide from the resin, cyclization of the cleaved peptide (using (1-cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino-mopholino-carbeniumhexafluorophosphate (COMU) as the cyclizing agent), and purification of the cyclic peptide. 
     Compound 1805 ((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-9-(propoxymethyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     
       
         
         
             
             
         
       
     
     LCMS (ESI) m/z=1415.9 (M−H)− 
     Retention time: 1.923 min (analysis condition SSC-FA-03) 
     Synthesis of Compound 2172 and Compound 2173 
     Compound 2172 and Compound 2173 were synthesized using Compound aa155-resin (2-[(2R)-3-(dimethylamino)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-oxopropyl]sulfanylacetic acid-2-chlorotrityl resin, Fmoc-MeGly(cPent)-OH), Fmoc-MeIle-OH, Fmoc-cLeu-OH, Fmoc-Pro-OH, Fmoc-Hph(4-CF3-3-Cl)—OH, Fmoc-MeGly-OH, Fmoc-MeCha-OH, Fmoc-MePhe(4-Me)-OH, and Fmoc-Ile-OH as raw materials, and using, by a method similar to the synthesis of any one of Compounds 1 to 762, Compounds 764 to 1027, Compounds 1029 to 1410, Compounds 1412 to 2020, and Compound 2111, and the target Compound 2172 (1.31 mg, 3%) and Compound 2173 (1.42 mg, 3%) were obtained. 
     Compound 2172((3S,9S,18S,24R,27S,33S)-18-[(2S)-butan-2-yl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-27-cyclopentyl-N,N,7,10,13,16,25,28-octamethyl-2,5,8,11,14,17,20,26,29,32-decaoxospiro[22-thia-1,4,7,10,13,16,19,25,28,31-decazabicyclo[31.3.0]hexatriacontane-30,1′-cyclopentane]-24-carboxamide) 
     
       
         
         
             
             
         
       
     
     LCMS (ESI) m/z=1307.1 (M+H)+ 
     Retention time: 1.48 min (analysis condition SQDFA05long) 
     Compound 2173((3S,9S,18S,24R,27S,33S)-18,27-bis[(2S)-butan-2-yl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-N,N,7,10,13,16,25,28-octamethyl-9-[(4-methylphenyl)methyl]-2,5,8,11,14,17,20,26,29,32-decaoxospiro[22-thia-1,4,7,10,13,16,19,25,28,31-decazabicyclo[31.3.0]hexatriacontane-30.1′-cyclopentane]-24-carboxamide) 
     
       
         
         
             
             
         
       
     
     LCMS (ESI) m/z=1303.1 (M+H)+ 
     Retention time: 1.16 min (analysis condition SQDFA05long) 
     Synthesis of Compound 2174 ((3S,9S,12S,17S,20S,23S,29R,32S,38S)-20-[(2S)-butan-2-yl]-32-cyclopentyl-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-N,N,7,10,17,18,24,30,33-nonamethyl-23-(2-methylpropyl)-2,5,8,11,16,19,22,25,31,34,37-undecaoxo-9-(propoxymethyl)spiro[27-thia-1,4,7,10,15,18,21,24,30,33,36-undecazatricyclo[36.3.0.012e15]hentetracontane-35.1′-cyclopentane]-29-carboxamide) 
     
       
         
         
             
             
         
       
     
     The peptide chain was elongated by the common peptide elongation method described herein, using Compound aa155-resin (2-[(2R)-3-(dimethylamino)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-oxopropyl]sulfanylacetic acid-2-chlorotrityl resin) as a raw material, and using Fmoc-MeGly(cPent)-OH, Fmoc-cLeu-OH, Fmoc-Pro-OH, Fmoc-Hph(4-CF3-3-F)—OH, Fmoc-MeGly-OH, Fmoc-MeSer(nPr)—OH, Fmoc-Aze(2)-OH, Fmoc-MeAla-OH, and Fmoc-Ile-OH in that order. The following operation was carried out while leaving the Fmoc group at the N terminus. 
     The resin was sequentially washed with DMF (four times with 0.7 mL), DCM (twice with 0.7 mL), and toluene (twice with 0.7 mL). A solution of diazabicycloundecene (DBU) in toluene (2% v/v, 0.7 mL) was added thereto, the solution was allowed to react for ten minutes, and then Fmoc group deprotection was performed. After removing the solution from the frit, the resin was sequentially washed with toluene (twice with 0.7 mL) and DCM (twice with 0.7 mL) 
     To the above-obtained resin was added a solution of Fmoc-MeLeu-OH (49 mg, 0.134 mmol, 4 equivalents), [ethylcyano(hydroxyimino)acetate-02]tri-1-pyrrolidinylphosphonium hexafluorophosphoric acid (PyOxym) (70.6 mg, 0.134 mmol, 4 equivalents), and DIPEA (0.035 mL, 0.2 mmol, 6 equivalents) in DCM (0.7 mL), and this was allowed to stand at room temperature for three hours. After removing the solution from the frit, the resin was washed with DCM (three times with 0.7 mL), and further washed with DMF (three times with 0.7 mL). To the obtained resin was added a solution of diazabicycloundecene (DBU) in DMF (2% v/v, 0.7 mL), this was allowed to react for 15 minutes to deprotect Fmoc group, and then the solution was removed from the frit. The obtained resin was washed with DMF (four times with 0.7 mL), and then with DCM (four times with 1.25 mL). 
     On the resin obtained by the above-mentioned method, 2,2,2-trifluoroethanol (TFE)/DCM (1/1, v/v, 2 mL) containing 0.75% DIPEA was added, and this was shaken at room temperature for two hours to carry out the reaction to cleave the peptide chain from the resin. After the reaction, the solution in the tube was recovered from the frit. The operation of adding 2,2,2-trifluoroethanol (TFE)/DCM (1/1, v/v, 1 mL) to the remaining resin and recovering the solution from the frit was performed twice. All the obtained cleavage solutions were combined, DMF (4 mL) was added, and the solvent was evaporated under reduced pressure by a high throughput centrifugal evaporator (HT-12) manufactured by Genevac. 
     The residue obtained by the above-mentioned method was dissolved in a mixture of DMF (4 mL) and DCM (4 mL), a solution of (1-cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino-mopholino-carbeniumhexafluorophosphate (COMU) in DMF (0.5 M, 0.1 mL), and DIPEA (0.015 mL) were added thereto, and a cyclocondensation reaction between the N-terminal amino group and the side chain carboxylic acid was carried out by stirring at room temperature for two hours. After confirming the production of the target cyclic peptide by LC/MS measurement (SQ Detector 2, manufactured by Waters), the solvent was evaporated from the reaction solution under reduced pressure by a high throughput centrifugal evaporator (HT-12) manufactured by Genevac. 
     DMF was added to the residue obtained by the above-mentioned method, insoluble substances were removed by filtration, and then purification by preparative-HPLC (on a Waters Auto Purification System, YMC-Actus Triart Phenyl (internal diameter of 20 mm, length of 100 mm) was used as the column, and methanol-aqueous ammonium acetate solution (50 mmol/L) was used as the mobile phase) gave the target Compound 2174 (5.55 mg, 12%). 
     LCMS (ESI) m/z=1420.3 (M+H)+ 
     Retention time: 1.10 min (analysis condition SQDFA05long) 
     Synthesis of Compounds 2175 to 2179 
     Compounds 2175 to 2179 were synthesized by a method similar to the synthesis of Compound 2174, using Compound aa155-resin (2-[(2R)-3-(dimethylamino)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-oxopropyl]sulfanylacetic acid-2-chlorotrityl resin) as a raw material, and using Fmoc-MeGly(cPent)-OH, Fmoc-MeIle-OH, Fmoc-cLeu-OH, Fmoc-Pro-OH, Fmoc-Hyp(Et)-OH, Fmoc-Hph(4-CF3-3-Cl)—OH, Fmoc-Hph(4-CF3-3-F)—OH, Fmoc-Hph(4-CF3-35-F2)-OH, Fmoc-MeGly-OH, Fmoc-MeCha-OH, Fmoc-MePhe(4-Me)-OH, Fmoc-Aze(2)-OH, Fmoc-MeAla-OH, Fmoc-Ile-OH, and Fmoc-MeLeu-OH as Fmoc amino acids. 
     Compound 2175 ((3S,9S,18S,21S,27R,30S,36S)-18-[(2S)-butan-2-yl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclohexylmethyl)-30-cyclopentyl-N,N,7,10,13,16,22,28,31-nonamethyl-21-(2-methylpropyl)-2,5,8,11,14,17,20,23,29,32,35-undecaoxospiro[25-thia-1,4,7,10,13,16,19,22,28,31,34-undecazabicyclo[34.3.0]nonatriacontane-33,1′-cyclopentane]-27-carboxamide) 
     
       
         
         
             
             
         
       
     
     LCMS (ESI) m/z=1434.3 (M+H)+ 
     Retention time: 1.64 min (analysis condition SQDFA05long) 
     Compound 2176 ((3S,9S,12S,17S,20S,23S,29R,32S,38S,40R)-20-[(2S)-butan-2-yl]-9-(cyclohexylmethyl)-32-cyclopentyl-3-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-40-ethoxy-N,N,7,10,17,18,24,30,33-nonamethyl-23-(2-methylpropyl)-2,5,8,11,16,19,22,25,31,34,37-undecaoxospiro[27-thia-1,4,7,10,15,18,21,24,30,33,36-undecazatricyclo[36.3.0.012,15]hentetracontane-35,1′-cyclopentane]-29-carboxamide) 
     
       
         
         
             
             
         
       
     
     LCMS (ESI) m/z=1506.4 (M+H)+ 
     Retention time: 1.88 min (analysis condition SQDFA05long) 
     Compound 2177 ((3S,9S,12S,17S,20S,23S,29R,32S,38S)-20-[(2S)-butan-2-yl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-32-cyclopentyl-N,N,7,10,17,18,24,30,33-nonamethyl-9-[(4-methylphenyl)methyl]-23-(2-methylpropyl)-2,5,8,11,16,19,22,25,31,34,37-undecaoxospiro[27-thia-1,4,7,10,15,18,21,24,30,33,36-undecazatricyclo[36.3.0.012,15]hentetracontane-35,1′-cyclopentane]-29-carboxamide) 
     
       
         
         
             
             
         
       
     
     LCMS (ESI) m/z=1468.3 (M+H)+ 
     Retention time: 1.55 min (analysis condition SQDFA05long) 
     Compound 2178 ((3S,9S,18S,21S,27R,30S,36S)-18,30-bis[(2S)-butan-2-yl]-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-N,N,7,10,13,16,22,28,31-nonamethyl-9-[(4-methylphenyl)methyl]-21-(2-methylpropyl)-2,5,8,11,14,17,20,23,29,32,35-undecaoxospiro[25-thia-1,4,7,10,13,16,19,22,28,31,34-undecazabicyclo[34.3.0]nonatriacontane-33,1′-cyclopentane]-27-carboxamide) 
     
       
         
         
             
             
         
       
     
     LCMS (ESI) m/z=1430.3 (M+H)+ 
     Retention time: 1.43 min (analysis condition SQDFA05long) 
     Compound 2179 ((3S,9S,12S,17S,20S,23S,29R,32S,38S)-20-[(2S)-butan-2-yl]-9,32-dicyclopentyl-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-N,N,7,10,17,18,24,30,33-nonamethyl-23-(2-methylpropyl)-2,5,8,11,16,19,22,25,31,34,37-undecaoxospiro[27-thia-1,4,7,10,15,18,21,24,30,33,36-undecazatricyclo[36.3.0.012,15]hentetracontane-35,1′-cyclopentane]-29-carboxamide) 
     
       
         
         
             
             
         
       
     
     LCMS (ESI) m/z=1416.3 (M+H)+ 
     Retention time: 1.17 min (analysis condition SQDFA05long) 
     The mass spectral values and the liquid chromatography retention times of cyclic peptide compounds described in Examples are described in Table 22. 
     1-4. Cyclic Peptide Synthesis by Peptide Modification 
     1-4-1. Peptide Synthesis Through N-Methylation of TFA Amides on Resins 
     Synthesis of Compound 2159 ((5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,11-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,15,16,19,21,21,22,33,36-undecamethyltetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontyne-4,7,10,13,17,20,23,28,31,34,37(14H)-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 2159 was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
     
     To a solution of 2-amino-2-methylpropanoic acid (H-Aib-OH, CAS No. 62-57-7) (2.5 g, 24.24 mmol) and DIPEA (4.66 mL, 26.7 mmol) in methanol (12.12 mL) was added ethyl trifluoroacetate (3.76 mL, 31.5 mmol), and the mixture was stirred at 60° C. for 20 hours. The reaction solution was cooled to room temperature, and the solvent was evaporated under reduced pressure. To the resulting residue was added 1 mol/L aqueous hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give 2-methyl-2-(2,2,2-trifluoroacetamido)propanoic acid (TFA-Aib-OH) (2.2 g, 46%). 
     LCMS (ESI) m/z=198 (M−H)− 
     Retention time: 0.40 min (analysis condition SQDFA05) 
     Compound 2159-a-resin was obtained by elongating Fmoc-MeVal-OH using the basic peptide elongation method described in the present Examples in a reaction vessel equipped with a filter, and then elongating TFA-Aib-OH (2-methyl-2-(2,2,2-trifluoroacetamido)propanoic acid) obtained by the above formulation, with Compound aa139-resin ((3R)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]butanoic acid-2-chlorotrityl resin, Fmoc-D-3-MeAbu-O-Trt(2-Cl)resin) (100 mg, 0.343 mmol/g, 0.0343 mmol) used as a raw material. 
     The obtained Compound 2159-a-resin was swollen with DCM (1 mL) and then washed with DMF (1 mL) four times. A solution of phosphazene base P 1 -tBu (38 μL, 0.150 mmol) in DMF (180 μL) and a solution of methyl iodide (62 μL, 1 mmol) in DMF (180 μL) were added, and the vessel was shaken at 40° C. for 30 minutes under sealed conditions. After removing the reaction solution, the resin was washed with DMF (1 mL) four times and further washed with DCM (1 mL) four times to give Compound 2159-b-resin. The obtained resin was partially cleaved with TFE/DCM (1/1) and analyzed by LC/MS to confirm the progress of the reaction. 
     LCMS (ESI) m/z=424 (M−H)− 
     Retention time: 0.57 min (analysis condition SQDFA05) 
     Sodium borohydride (NaBH 4 ) (758 mg, 20 mmol) was placed in a flask, pumped up, and then, under a nitrogen atmosphere, dissolved in triglyme (10 mL) to provide Solution A. The above-obtained Compound 2159-b-resin was swollen with DCM (1 mL) and then washed with THF (0.7 mL) four times. To the resin were added THF (0.5 mL), methanol (0.25 mL), and Solution A (0.25 mL), and the flask was shaken at room temperature for 40 minutes in an open system. After removing the reaction solution, methanol (0.7 mL) was added, and after one minute, the solution was discarded. This resin-washing operation was repeated four times. Further, the resin was similarly washed with DCM (0.7 mL) four times to give Compound 2159-c-resin. The obtained resin was partially cleaved with TFE/DCM (1/1) and analyzed by LC/MS to confirm the progress of the reaction. 
     LCMS (ESI) m/z=330 (M+H)+ 
     Retention time: 0.33 min (analysis condition SQDFA05) 
     Subsequent peptide elongation, cyclization, and purification steps were conducted according to the basic route to give Compound 2159 ((5S,8S,11S,15R,18S,23aS,29S,35S,37aS)-8,11-di((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-isopropyl-5,6,12,15,16,19,21,21,22,33,36-undecamethyltetracosahydro-2H-azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontyne-4,7,10,13,17,20,23,28,31,34,37(14H)-undecone) (4.1 mg, 9%). The LC/MS data are as described in Table 22. 
     Compounds 2152-2158 and Compound 2160 were synthesized by the same method as in the synthesis of Compound 2159. The LC/MS data are as described in Table 22. 
     1-4-2. Peptide Modification by Alkylation of OH 
     Synthesis of Compound 2116 ((3S,9S,18S,21S,25R,28S,34S,36R)-36-benzyloxy-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     
       
         
         
             
             
         
       
     
     In a glass screw cap vial were mixed Compound 1483 ((3S,9S,18S,21S,25R,28S,34S,36R)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-36-hydroxy-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) synthesized by the basic peptide synthesis described in the present Examples (5 mg, 3.83 μmol), silver(I) oxide (26.6 mg, 0.115 mmol), and benzyl bromide (19.7 mg, 0.115 mmol), 1,4-dioxane (0.05 mol/L, 77 μL) was added, the vial was capped, and reaction was performed at 60° C. overnight. The reaction solution was filtered, and the filtrate was then purified by reverse phase medium pressure column chromatography (acetonitrile/water, containing 0.3% formic acid) to give Compound 2116 ((3S,9S,18S,21S,25R,28S,34S,36R)-36-benzyloxy-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-21,28-diisobutyl-7,10,13,16,22,25,29-heptamethyl-18-[(1S)-1-methylpropyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (3.7 mg, 70%). The LC/MS data are as described in Table 22. 
     Synthesis of Compounds 2118, 2125, 2128, 2130, 2131, 2133, 2134, 2138, and 2139 
     Compounds 2118, 2125, 2128, 2130, 2131, 2133, 2134, 2138, and 2139 were synthesized by the same method as in the synthesis of Compound 2116 using Compound 875 ((3S,9S,18S,21S,25S,28S,34S,36R)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-36-hydroxy-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) synthesized by the basic peptide elongation method described in the present Examples, as a raw material, and using alkylating agents provided in the following table. Purification was conducted by reverse phase medium pressure column chromatography or preparative HPLC. The following table describes target compound peptides, alkylating agents used for reactions, amounts (mg) of Compound 875 used as a raw material, and yield amounts (mg) and yield percentages (%) of the target compounds. The LC/MS data are as described in Table 22. 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 9 
               
               
                   
               
               
                   
                   
                 Raw 
                 Target 
                   
               
               
                 Target 
                   
                 material 
                 compound 
                 Yield 
               
               
                 compound 
                 Alkylating agent 
                 mg 
                 mg 
                 % 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Compound 
                 2-chlorobenzyl 
                 5.4 
                 3 
                 50 
               
               
                 2138 
                 bromide 
               
               
                 Compound 
                 ethyl 
                 10.8 
                 7 
                 63 
               
               
                 2118 
                 iodide 
               
               
                 Compound 
                 3-chlorobenzyl 
                 5.4 
                 2 
                 35 
               
               
                 2134 
                 bromide 
               
               
                 Compound 
                 4-chlorobenzyl 
                 5.4 
                 1.9 
                 32 
               
               
                 2133 
                 bromide 
               
               
                 Compound 
                 2-methylbenzyl 
                 5.4 
                 3.1 
                 54 
               
               
                 2139 
                 bromide 
               
               
                 Compound 
                 3-methylbenzyl 
                 5.4 
                 2.3 
                 39 
               
               
                 2125 
                 bromide 
               
               
                 Compound 
                 3-methoxybenzyl 
                 5.4 
                 2 
                 34 
               
               
                 2131 
                 bromide 
               
               
                 Compound 
                 4-methylbenzyl 
                 5.4 
                 2.9 
                 50 
               
               
                 2130 
                 bromide 
               
               
                 Compound 
                 4-(difluoromethoxy)benzyl 
                 5.4 
                 2.3 
                 38 
               
               
                 2128 
                 bromide 
               
               
                   
               
            
           
         
       
     
     Synthesis of Compounds 2132, 2126, 2129, 2127, 2137, 2141, 2136, 2140, and 2135 
     Compounds 2132, 2126, 2129, 2127, 2137, 2141, 2136, 2140, and 2135 were synthesized by the same method as in the synthesis of Compound 2116 using Compound 544 ((3S,9S,18S,21S,25S,28S,34S,36S)-9-(cyclohexylmethyl)-3-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-36-hydroxy-21,28-diisobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) synthesized by the basic peptide elongation method described in the present Examples, as a raw material, and using alkylating agents provided in the following table. Purification was conducted by reverse phase medium pressure column chromatography or preparative HPLC. The following table describes target compound peptides, alkylating agents used for reactions, amounts (mg) of Compound 544 used as a raw material, and yield amounts (mg) and yield percentages (%) of the target compounds. The LC/MS data are as described in Table 22. 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 10 
               
               
                   
               
               
                   
                   
                 Raw 
                 Target 
                   
               
               
                 Target 
                   
                 material 
                 compound 
                 Yield 
               
               
                 compound 
                 Alkylating agent 
                 mg 
                 mg 
                 % 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Compound 
                 2-chlorobenzyl 
                 5.4 
                 0.7 
                 11 
               
               
                 2132 
                 bromide 
               
               
                 Compound 
                 3-chlorobenzyl 
                 5.4 
                 0.3 
                 6 
               
               
                 2126 
                 bromide 
               
               
                 Compound 
                 4-chlorobenzyl 
                 5.4 
                 0.7 
                 11 
               
               
                 2129 
                 bromide 
               
               
                 Compound 
                 ethyl 
                 10.8 
                 2.6 
                 23 
               
               
                 2127 
                 iodide 
               
               
                 Compound 
                 2-methylbenzyl 
                 5.4 
                 2.4 
                 41 
               
               
                 2137 
                 bromide 
               
               
                 Compound 
                 3-methylbenzyl 
                 5.4 
                 2.5 
                 42 
               
               
                 2141 
                 bromide 
               
               
                 Compound 
                 3-methoxybenzyl 
                 5.4 
                 1.7 
                 29 
               
               
                 2136 
                 bromide 
               
               
                 Compound 
                 4-methylbenzyl 
                 5.4 
                 1.7 
                 29 
               
               
                 2140 
                 bromide 
               
               
                 Compound 
                 4-(difluoromethoxy)benzyl 
                 5.4 
                 2 
                 32 
               
               
                 2135 
                 bromide 
               
               
                   
               
            
           
         
       
     
     Synthesis of Compounds 2043, 2044, and 2045 
     A precursor peptide shown below (Compound 2044-a) (230 mg, 0.188 mmol, 39%) was synthesized by the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (0.3 mmol/g, 1.6 g, 0.48 mmol) as a raw material. 
     
       
         
         
             
             
         
       
     
     LCMS (ESI) m/z=1224 (M+H)+ 
     Retention time: 0.82 min (analysis condition SQDFA05) 
     Compounds 2043, 2044, and 2045 were synthesized by the same method as in the synthesis of Compound 2116 using Compound 2044-a as a raw material, and using alkylating agents provided in the following table. Purification was conducted by reverse phase medium pressure column chromatography or preparative HPLC. The following table describes target compound peptides, alkylating agents used for reactions, amounts (mg) of raw material Compound 2044-a, and yield amounts (mg) and yield percentages (%) of the target compounds. The LC/MS data are as described in Table 22. 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 11 
               
               
                   
               
               
                   
                   
                 Raw 
                 Target 
                   
               
               
                 Target 
                   
                 material 
                 compound 
                 Yield 
               
               
                 compound 
                 Alkylating agent 
                 mg 
                 mg 
                 % 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Compound 2044 
                 4-chlorobenzyl bromide 
                 20 
                 8.2 
                 37 
               
               
                 Compound 2045 
                 3-chlorobenzyl bromide 
                 9.9 
                 6 
                 55 
               
               
                 Compound 2043 
                 2-chlorobenzyl bromide 
                 9.9 
                 1 
                 9 
               
               
                   
               
            
           
         
       
     
     Synthesis of Compound 2117 ((3S,9S,18S,21S,25S,28S,34S,36S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-(2-hydroxyethoxy)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     To Compound 1374 ((3S,9S,18S,21S,25S,28S,34S,36S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-hydroxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (5 mg, 3.43 μmol) as a raw material were added 2-(2-bromoethoxy)tetrahydro-2H-pyran (14.3 mg, 0.0686 mmol) and tetrabutylammonium bromide (3.32 mg, 10.29 μmol), after which dichloromethane (0.04 mol/L, 86 μL) and a 5 mol/L aqueous sodium hydroxide solution (27.4 μL) were added and the mixture was reacted at room temperature for five days. The reaction solution was purified by reverse phase medium pressure column chromatography (acetonitrile/water, containing 0.3% formic acid) to give Compound 2117-a (3.3 mg, 61%). 
     LCMS (ESI) m/z=1586 (M+H)+ 
     Retention time: 0.85 min (analysis condition SQDFA50) 
     Compound 2117-a (3.3 mg, 2.08 μmol) was subjected to deprotection of the THP protecting group according to the basic peptide elongation method described in the present Examples, and was then purified to give Compound 2117 ((3S,9S,18S,21S,25S,28S,34S,36S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-(2-hydroxyethoxy)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (1.59 mg, 54%). The LC/MS data are as described in Table 22. 
     Synthesis of Compound 2122 ((3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-(2-hydroxyethoxy)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Compound 2122-a (3.1 mg, 57%) was obtained by the same method as in the synthesis of Compound 1374-a using Compound 1376 ((3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-hydroxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (5 mg, 3.43 μmol) as a raw material. 
     LCMS (ESI) m/z=1585.9 (M+H)+ 
     Retention time: 0.95 min (analysis condition SQDFA50) 
     Compound 2122-a (3.1 mg) was subjected to deprotection of the THP protecting group according to the basic peptide elongation method described in the present Examples, and was then purified to give Compound 2122 ((3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-(2-hydroxyethoxy)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (1.3 mg, 44%). The LC/MS data are as described in Table 22. 
     Synthesis of Compounds 2121, 2119, 2124, 2120, and 2123 
     Compounds 2121, 2119, and 2124 were synthesized by the same method as in the synthesis of Compound 2117-a using Compound 1376 ((3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-hydroxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) as a raw material. Purification was conducted by reverse phase medium pressure column chromatography or preparative HPLC. The following table describes target compound peptides, alkylating agents used for reactions, amounts (mg) of Compound 1376 used as a raw material, and yield amounts (mg) and yield percentages (%) of the target compounds. The LC/MS data are as described in Table 22. 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 12 
               
               
                   
               
               
                   
                   
                 Raw 
                 Target 
                   
               
               
                 Target 
                   
                 material 
                 compound 
                 Yield 
               
               
                 compound 
                 Alkylating agent 
                 mg 
                 mg 
                 % 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Compound 2124 
                 3-bromomethylthiophene 
                 5 
                 2.1 
                 39 
               
               
                 Compound 2121 
                 3-(chloromethyl)pyridine 
                 15 
                 0.67 
                 4 
               
               
                 Compound 2119 
                 2,2-difluoroethyl 
                 5 
                 4.27 
                 82 
               
               
                   
                 triflate 
               
               
                   
               
            
           
         
       
     
     Compounds 2120 and 2123 were synthesized by the same method as in the synthesis of Compound 2117-a using Compound 1374 ((3S,9S,18S,21S,25S,28S,34S,36S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-36-hydroxy-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) as a raw material. Purification was conducted by reverse phase medium pressure column chromatography or preparative HPLC. The following table describes target compound peptides, alkylating agents used for reactions, amounts (mg) of Compound 1374 used as a raw material, and yield amounts (mg) and yield percentages (%) of the target compounds. The LC/MS data are as described in Table 22. 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 13 
               
               
                   
               
               
                   
                   
                 Raw 
                 Target 
                   
               
               
                 Target 
                   
                 material 
                 compound 
                 Yield 
               
               
                 compound 
                 Alkylating agent 
                 mg 
                 mg 
                 % 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Compound 2120 
                 3-(chloromethyl)pyridine 
                 15 
                 1.3 
                 8 
               
               
                 Compound 2123 
                 2,2-difluoroethyl 
                 5 
                 5 
                 96 
               
               
                   
                 triflate 
               
               
                   
               
            
           
         
       
     
     1-4-3. Peptide Modification by Reductive Coupling Reaction 
     Synthesis of Compound 2085 ((5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(4-(difluoromethyl)-3-fluorophenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidin-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecazacyclotetratriacontyne-21,1′-cyclopentane]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecone) 
     Compound 2085 was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
     
     Compound 2085-a (772 mg, 0.531 mmol, 77%) was obtained by the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (0.531 mmol/g, 1.3 g, 0.69 mmol) as a raw material. 
     LCMS (ESI) m/z=1360 (M+H)+ 
     Retention time: 1.01 min (analysis condition SQDFA05) 
     Compound 2085-a (772 mg, 0.568 mmol) and tetrakis(triphenylphosphine)palladium(0) (6.56 mg, 5.68 μmol) were mixed, DCM (1.2 ml) and phenylsilane (49 μl, 0.398 mmol) were added under a nitrogen atmosphere, and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound 2085-b (255 mg, 34%). 
     LCMS (ESI) m/z=1320 (M+H)+ 
     Retention time: 0.87 min (analysis condition SQDFA05) 
     Compound 2085-b (255 mg, 0.193 mmol), N-hydroxyphthalimide (40.9 mg, 0.25 mmol), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (WSCI—HCl) (74.1 mg, 0.386 mmol) were dissolved in DCM (2 ml), and the reaction solution was stirred at room temperature for 2 hours and 15 minutes. The reaction mixture was diluted with DCM and washed with water twice. The organic layer was dried over sodium sulfate and then concentrated under reduced pressure to give Compound 2085-c as a crude product (299 mg, quant.). 
     LCMS (ESI) m/z=1465 (M+H)+ 
     Retention time: 1.00 min (analysis condition SQDFA05) 
     Nickel bromide trihydrate (NiBr 23 H 2 O) (2.79 mg, 10.24 μmol) and 4,4′-di-tert-butyl-2,2′-bipyridyl (2.75 mg, 1.052 μmol) were dissolved in DMA (60 μL) under a nitrogen atmosphere to prepare a Ni solution. 
     To a mixture of Compound 2085-c (15.0 mg, 10.24 μmol), zinc powder (10 mg, 0.154 mmol), and 4-bromo-1-(difluoromethyl)-2-fluorobenzene (12.0 mg, 51.2 μmol) was added DMA (60 μL) under a nitrogen atmosphere, after which the above-prepared Ni solution was added and the mixture was stirred at room temperature for 16 hours. The reaction solution was then purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid), and the fractions were lyophilized to give Compound 2085 ((5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-35-(cyclohexylmethyl)-18-cyclopentyl-29-(4-(difluoromethyl)-3-fluorophenethyl)-11-isobutyl-5,6,12,16,19,33,36-heptamethyl-15-(piperidin-1-carbonyl)docosahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecazacyclotetratriacontyne-21,1′-cyclopentane]-4,7,10,13,17,20,23,28,31,34,37(14H,22H)-undecone) (6.2 mg, 42.7%). The LC/MS data are as described in Table 22. 
     Synthesis of Compounds 2077, 2076, 2072, 2080, 2078, 2074, 2057, 2067, 2070, 2065, 2064, 2084, 2063, 2060, and 2069 
     Compounds 2077, 2076, 2072, 2080, 2078, 2074, 2057, 2067, 2070, 2065, 2064, 2084, 2063, 2060, and 2069 were obtained by the same synthesis method as in Compound 2085 using Compound 2085-c (15 mg) and using aryl bromides provided below (5 equivalents relative to the raw material peptide). The following table describes target compound peptides, aryl bromides used for reactions, and yield amounts (mg) and yield percentages (%) of the target compounds. The LC/MS data are as described in Table 22. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 14 
               
               
                   
               
               
                   
                   
                 Target 
                   
               
               
                 Target 
                   
                 compound 
                 Yield 
               
               
                 compound 
                 Aryl bromide 
                 mg 
                 % 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Compound 2077 
                 7-bromoquinoline 
                 7.6 
                 53 
               
               
                 Compound 2076 
                 4-bromo-1-(difluoromethoxy)- 
                 6.3 
                 43 
               
               
                   
                 2-fluorobenzene 
               
               
                 Compound 2072 
                 5-bromo-2-(trifluoromethyl) 
                 4.6 
                 31 
               
               
                   
                 benzonitrile 
               
               
                 Compound 2080 
                 4-bromo-2-methoxy-1- 
                 5.2 
                 35 
               
               
                   
                 (trifluoromethyl)benzene 
               
               
                 Compound 2078 
                 5-bromo-2-(trifluoromethyl) 
                 3.8 
                 26 
               
               
                   
                 pyridine 
               
               
                 Compound 2074 
                 5-bromo-2,2-difluoro-1,3- 
                 5.8 
                 40 
               
               
                   
                 benzodioxole 
               
               
                 Compound 2057 
                 4-bromo-2-chloro-1- 
                 1.4 
                 9 
               
               
                   
                 (trifluoromethoxy)benzene 
               
               
                 Compound 2067 
                 4-bromo-2-fluoro-1- 
                 4.7 
                 31 
               
               
                   
                 (trifluoromethoxy)benzene 
               
               
                 Compound 2070 
                 6-bromoquinoline 
                 6 
                 42 
               
               
                 Compound 2065 
                 6-bromo-1-methyl-1H- 
                 4.6 
                 32 
               
               
                   
                 indole 
               
               
                 Compound 2064 
                 5-bromo-1-methyl-1H- 
                 4.4 
                 30 
               
               
                   
                 indole 
               
               
                 Compound 2084 
                 5-bromo-2-methoxypyridine 
                 5.8 
                 41 
               
               
                 Compound 2063 
                 5-bromobenzofuran 
                 3.8 
                 27 
               
               
                 Compound 2060 
                 5-bromo-2-(difluoromethyl) 
                 5.5 
                 38 
               
               
                   
                 pyridine 
               
               
                 Compound 2069 
                 2-bromo-5-(trifluoromethyl) 
                 3.8 
                 26 
               
               
                   
                 pyridine 
               
               
                   
               
            
           
         
       
     
     Synthesis of Compound 2058 ((3S,9S,18S,21S,25S,28S,34S′)-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(5′)-1-methylpropyl]-3-[2-(4-methylsulfonylphenyl)ethyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     Compound 2058 was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
     
     Compound 2058-a was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) as a raw material. Further, Compound 2058-b was obtained by the same method as in the synthesis of Compound 2085-b. Further, Compound 2058-c (299 mg, 0.206 mmol) was obtained by the same method as in the synthesis of Compound 2085-c. 
     LCMS (ESI) m/z=1453 (M+H)+ 
     Retention time: 1.03 min (analysis condition SQDFA05) 
     Compound 2058 ((3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-21-isobutyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-3-[2-(4-methylsulfonylphenyl)ethyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (4.1 mg, 28%) was obtained by the same method as in the synthesis of Compound 2085 using Compound 2058-c (15 mg, 10.32 μmol) as a raw material and using 1-bromo-4-(methylsulfonyl)benzene (5 equivalents relative to the peptide) as an aryl halide. The LC/MS data are as described in Table 22. 
     Synthesis of Compound 2059 ((3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[2-(3,4,5-trichlorophenyl)ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     Compound 2059 was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
     
     Compound 2059-a was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(0-Trt(2-Cl)resin)-pip) (0.437 mmol/g, 3 g, 1.311 mmol) as a raw material. Further, Compound 2059-b was obtained by the same method as in the synthesis of Compound 2085-b. Further, Compound 2059-c (388 mg, 0.275 mmol, 21%) was obtained by the same method as in the synthesis of Compound 2085-c. 
     LCMS (ESI) m/z=1411 (M+H)+ 
     Retention time: 0.95 min (analysis condition SQDFA05) 
     Compound 2059 ((3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[2-(3,4,5-trichlorophenyl)ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (6.6 mg, 47%) was obtained by the same method as in the synthesis of Compound 2085 using Compound 2059-c (15 mg) as a raw material and using 5-bromo-1,2,3-trichlorobenzene (10 equivalents relative to the peptide) as an aryl halide. The LC/MS data are as described in Table 22. 
     Synthesis of Compounds 2081, 2075, 2062, 2066, and 2082 
     Compounds 2081, 2075, 2062, 2066, and 2082 were obtained by the same synthesis method as in Compound 2059 using Compound 2059-c (15 mg) as a raw material and using aryl halides provided below (10 equivalents relative to the raw material peptide). The following table describes target compound peptides, aryl halides used for reactions, and yield amounts (mg) and yield percentages (%) of the target compounds. The LC/MS data are as described in Table 22. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 15 
               
               
                   
               
               
                 Target 
                   
                 Yield 
                 Yield 
               
               
                 compound 
                 Aryl halide 
                 mg 
                 % 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Compound 2081 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6.9 
                 47 
               
               
                   
               
               
                   
                 Compound 2081-a 
                   
                   
               
               
                 Compound 2075 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 0.7 
                 5 
               
               
                   
               
               
                   
                 Compound 2075-a 
                   
                   
               
               
                 Compound 2062 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 9.4 
                 60 
               
               
                   
               
               
                   
                 Compound 2062-a 
                   
                   
               
               
                 Compound 2066 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3.3 
                 21 
               
               
                   
               
               
                   
                 Compound 2066-a 
                   
                   
               
               
                 Compound 2082 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8.3 
                 53 
               
               
                   
               
               
                   
                 Compound 2082-a 
                   
                   
               
               
                   
               
            
           
         
       
     
     Synthesis of Compound 2068 ((3S,9S,18S,21S,25S,28S,34S′)-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[2-(3,4,5-trichlorophenyl)ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31.1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone 
     Compound 2068 was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
     
     Compound 2068-a was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (0.437 mmol/g, 4.1 g, 1.79 mmol) as a raw material. Further, Compound 2068-b was obtained by the same method as in the synthesis of Compound 2085-b. Further, Compound 2068-c (553 mg, 0.403 mmol, 23%) was obtained by the same method as in the synthesis of Compound 2085-c. 
     LCMS (ESI) m/z=1371 (M+H)+ 
     Retention time: 0.86 min (analysis condition SQDFA05) 
     Nickel bromide trihydrate (5.97 mg, 0.022 mmol) and 4,4′-di-tert-butyl-2,2′-bipyridyl (5.87 mg, 0.022 mmol) were dissolved in DMA (110 μL) under a nitrogen atmosphere to prepare a Ni solution. 
     To Compound 2068-c (15.0 mg, 10.94 μmol), zinc powder (10.7 mg, 0.164 mmol), and 5-bromo-1,2,3-trichlorobenzene (28.5 mg, 109 μmol) was added DMA (55 μL) under a nitrogen atmosphere, after which the above-prepared Ni solution was added and the mixture was stirred at room temperature for five hours. The precipitate was filtered off, and the solvent was then evaporated under reduced pressure. n-Hexane/TFE/water=1/1/1 was added and the precipitate was filtered off, after which the n-hexane layer was removed and the solvent was evaporated under reduced pressure. The reaction solution was then purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound 2068 ((3S,9S,18S,21S,25S,28S,34S)-9-(cyclohexylmethyl)-28-isopropyl-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[2-(3,4,5-trichlorophenyl)ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (5.0 mg, 33%). The LC/MS data are as described in Table 22. 
     Synthesis of Compounds 2061, 2071, 2079, 2083, and 2073 
     Compounds 2061, 2071, 2079, 2083, and 2073 were obtained by the same synthesis method as in Compound 2068 using Compound 2068-c (15 mg) as a raw material and using aryl halides provided below (10 equivalents relative to the raw material peptide). The following table describes target compound peptides, aryl halides used for reactions, and yield amounts (mg) and yield percentages (%) of the target compounds. The LC/MS data are as described in Table 22. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 16 
               
               
                   
               
               
                 Target 
                   
                 Yield 
                 Yield 
               
               
                 compound 
                 Aryl halide 
                 mg 
                 % 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Compound 2061 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6.8 
                 46 
               
               
                   
               
               
                   
                 Compound 2081-a 
                   
                   
               
               
                 Compound 2071 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2.5 
                 7 
               
               
                   
               
               
                   
                 Compound 2075-a 
                   
                   
               
               
                 Compound 2079 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1.1 
                 7 
               
               
                   
               
               
                   
                 Compound 2062-a 
                   
                   
               
               
                 Compound 2083 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 7.2 
                 47 
               
               
                   
               
               
                   
                 Compound 2066-a 
                   
                   
               
               
                 Compound 2073 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 9.2 
                 60 
               
               
                   
               
               
                   
                 Compound 2082-a 
                   
                   
               
               
                   
               
            
           
         
       
     
     Aryl halides used for synthesizing Compounds 2081, 2075, 2062, 2066, 2082, 2061, 2071, 2079, 2083, and 2073 were synthesized as follows. 
     Synthesis of Compound 2081-a (1,2-dichloro-5-iodo-3-methoxybenzene) 
     
       
         
         
             
             
         
       
     
     To a solution of 2,3-dichloroanisole (1.0 g, 5.65 mmol) in TBME (28.2 mL) were added bis(pinacolato)diboron (B 2 pin 2 ) (2.15 g, 8.48 mmol) and (1,5-cyclooctadiene)(methoxy)iridium(I) (dimer) ([Ir(COD)(OMe)] 2 ) (0.187 g, 0.282 mmol), and the mixture was stirred at room temperature for two hours under a nitrogen atmosphere. The solvent was evaporated under reduced pressure, DMF (50 mL) was added, copper(I) iodide (CuI) (1.61 g, 8.47 mmol) was further added, and the mixture was stirred at 80° C. for four hours in air. After cooling to room temperature, n-hexane/ethyl acetate=1/1 (100 mL) was added and the mixture was sequentially washed with 100 mL each of a saturated aqueous ammonium chloride solution, a saturated aqueous sodium thiosulfate solution, a saturated aqueous sodium bicarbonate solution, and 50% saline. This was dried over anhydrous sodium sulfate and filtered off, after which the solvent was evaporated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid). The fractions were collected, concentrated, then dissolved in n-hexane/ethyl acetate=1/1, and washed with a saturated aqueous sodium bicarbonate solution. This was dried over anhydrous sodium sulfate and filtered off, after which the solvent was evaporated under reduced pressure to give Compound 2081-a (1,2-dichloro-5-iodo-3-methoxybenzene) (514 mg, 30%). 
     Retention time: 1.01 min (analysis condition SQDFA05) 
       1 H-NMR (DMSO-D 6 ) δ:7.60 (1H, d, J=1.9 Hz), 7.45 (1H, d, J=1.9 Hz), 3.90 (3H, s). 
     Synthesis of Compound 2075-a (2,3-dichloro-5-iodobenzonitrile) 
     
       
         
         
             
             
         
       
     
     To a solution of 2,3-dichlorobenzonitrile (500 mg, 2.91 mmol) in THF (14.5 mL) were added bis(pinacolato)diboron (B 2 pin 2 ) (1.11 g, 4.36 mmol) and (1,5-cyclooctadiene)(methoxy)iridium(I) (dimer) ([Ir(COD)(OMe)] 2 ) (96 mg, 0.145 mmol), and the mixture was stirred at 60° C. for one hour under a nitrogen atmosphere. The solvent was evaporated under reduced pressure, DMF (30 mL) was added, copper(I) iodide (CuI) (830 mg, 4.36 mmol) and N-iodosuccinimide (NIS) (981 mg, 4.36 mmol) were further added, and the mixture was stirred at 80° C. for six hours in air. After cooling to room temperature, n-hexane/ethyl acetate=1/1 (30 mL) was added and the mixture was sequentially washed with 60 mL each of a saturated aqueous ammonium chloride solution, a saturated aqueous sodium bicarbonate solution, and 50% saline. This was dried over anhydrous sodium sulfate and filtered off, after which the solvent was evaporated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid). The fractions were collected, concentrated, then dissolved in n-hexane/ethyl acetate=1/1, and washed with a saturated aqueous sodium bicarbonate solution. This was dried over anhydrous sodium sulfate and filtered off, after which the solvent was evaporated under reduced pressure to give Compound 2075-a (2,3-dichloro-5-iodobenzonitrile) (535 mg, 62%). 
     Retention time: 0.91 min (analysis condition SQDFA05) 
       1 H-NMR (DMSO-D 6 ) δ: 8.42 (1H, d, J=1.9 Hz), 8.39 (1H, d, J=1.9 Hz). 
     Synthesis of Compound 2062-a (5-bromo-1,2-dichloro-3-propan-2-yloxybenzene) 
     
       
         
         
             
             
         
       
     
     A solution of 5-bromo-1,2-dichloro-3-fluorobenzene (200 mg, 0.820 mmol) and 2-propanol (246 mg, 4.10 mmol) in DMF (1.0 mL) was cooled to 0° C. under ice-cooling, and sodium hydride (NaH) (60%, oil, 65.6 mg, 1.64 mmol) was added. The mixture was stirred at 60° C. for one hour and then cooled to 0° C., and sodium hydride (NaH) (60%, oil, 10.0 mg, 0.250 mmol) was added. The mixture was stirred at 60° C. for 30 minutes and then cooled to room temperature, a saturated aqueous ammonium chloride solution was added, and the mixture was extracted with ethyl acetate/n-hexane=1/1. This was dried over anhydrous sodium sulfate and filtered off, and the solvent was evaporated under reduced pressure to give Compound 2062-a (5-bromo-1,2-dichloro-3-propan-2-yloxybenzene) (211 mg, 91%). 
     Retention time: 1.11 min (analysis condition SQDFA05) 
       1 H-NMR (CDCl 3 ) δ: 7.22 (1H, d, J=2.1 Hz), 6.97 (1H, dd, J=2.1, 0.5 Hz), 4.58-4.51 (1H, m), 1.39 (6H, d, J=6.2 Hz). 
     Synthesis of Compound 2066-a (5-bromo-1-butoxy-2,3-dichlorobenzene) 
     
       
         
         
             
             
         
       
     
     Compound 2066-a (5-bromo-1-butoxy-2,3-dichlorobenzene) (211 mg, 86%) was obtained by the same synthesis method as in Compound 2062-a using 5-bromo-1,2-dichloro-3-fluorobenzene and n-butanol. 
     Retention time: 1.19 min (analysis condition SQDFA05) 
       1 H-NMR (CDCl 3 ) δ: 7.22 (1H, d, J=2.1 Hz), 6.95 (1H, d, J=2.1 Hz), 4.01 (2H, t, J=6.4 Hz), 1.86-1.79 (2H, m), 1.57-1.48 (2H, m), 0.99 (3H, t, J=7.4 Hz). 
     Synthesis of Compound 2082-a (5-bromo-1,2-dichloro-3-[(2-methylpropan-2-yl)oxy]benzene) 
     
       
         
         
             
             
         
       
     
     A solution of 5-bromo-1,2-dichloro-3-fluorobenzene (200 mg, 0.820 mmol) and tert-butanol (304 mg, 4.10 mmol) in DMF (1.0 mL) was cooled to 0° C. under ice-cooling, and sodium hydride (NaH) (60%, oil, 49.2 mg, 1.23 mmol) was added. The mixture was stirred at 60° C. for 1.5 hours and then cooled to 0° C. under ice-cooling, and sodium hydride (NaH) (60%, oil, 49.2 mg, 1.23 mmol) was added. The mixture was stirred at 60° C. for 30 minutes and then cooled to room temperature, and water (100 μL) was added. The reaction solution was then purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid), and the fractions were lyophilized to give Compound 2082-a (5-bromo-1,2-dichloro-3-[(2-methylpropan-2-yl)oxy]benzene) (127 mg, 52%). 
     Retention time: 1.15 min (analysis condition SQDFA05) 
       1 H-NMR (CDCl 3 ) δ: 7.34 (1H, d, J=2.1 Hz), 7.18 (1H, d, J=2.1 Hz), 1.44 (9H, s). 
     1-4-4. Peptide Modification by Sonogashira Coupling Reaction 
     Synthesis of Compound 2142 ((3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(3-ethinylphenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1 S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 2142-a (123.7 mg, 49%) was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (400 mg, 0.436 mmol/g, 0.1744 mmol) as a raw material. 
     LCMS (ESI) m/z=1443.6 (M+H)+ 
     Retention time: 1.06 min (analysis condition SQDFA05) 
     To a mixture of Compound 2142-a (30 mg, 0.021 mmol), bis(triphenylphosphine)palladium(II) dichloride (7.3 mg, 0.5 equivalents), and copper(I) iodide (4 mg, 1 equivalent) in DMF (208 μl) were added triethylamine (0.145 mL, 50 equivalents) and trimethylsilylacetylene (35.2 μL, 12 equivalents), and the mixture was stirred at room temperature for 30 minutes. Half of the reaction solution was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid). To the resulting fractions were added potassium carbonate (6 equivalents relative to the raw material peptide) and water (6 equivalents relative to the raw material peptide), and the mixture was concentrated under reduced pressure. To the residue were added methanol (500 μL) and water (50 μL). After confirming that the trimethylsilyl group was deprotected, the resulting reaction solution was concentrated under reduced pressure. The residue was dissolved in DMSO (1 mL) and then purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid), and the fractions containing the target compound were lyophilized. The residue was dissolved in DMSO (1 mL) and then concentrated under reduced pressure again to give Compound 2142 ((3S,9S,12S,18S,27S,30S,34S)-9-butyl-18-[(4-chlorophenyl)methyl]-12-[(3-ethinylphenyl)methyl]-3,30-diisobutyl-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-34-(piperidine-1-carbonyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone) (1.6 mg, 6%). The LC/MS data are as described in Table 22. 
     1-4-5. Peptide Modification by Click Chemistry 
     Synthesis of Compound 2113 ((3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-36-(triazol-1-yl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 2113-a (5.4 mg, 10%) was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (100 mg, 0.37 mmol/g, 0.037 mmol) as a raw material and using (2S,4R)-4-azido-1-Fmoc-pyrrolidine-2-carboxylic acid (Fmoc-L-Pro(4-N3)-OH(2S,4R), CAS No. 702679-55-8) as an Fmoc amino acid. 
     LCMS (ESI) m/z=1428.97 (M+H)+ 
     Retention time: 1.05 min (analysis condition SQDFA05) 
     To Compound 2113-a (5.4 mg, 3.8 μmol) were added copper(I) iodide (3 mg, 15.75 mol), acetonitrile (0.5 mL), DIPEA (50 μL, 286 μmol), and trimethylsilylacetylene (50 μL, 0.361 mmol) under a nitrogen atmosphere, and the mixture was stirred at room temperature for 16 hours. The reaction mixture was filtered through celite, washed with acetonitrile, and then concentrated under reduced pressure. The resulting crude product was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound 2113-b (6.4 mg, quant.). 
     LCMS (ESI) m/z=1527.06 (M+H)+ 
     Retention time: 1.10 min (analysis condition SQDFA05) 
     Compound 2113-b (6.4 mg) was dissolved in 1,4-dioxane (1 mL), and a solution of tetrabutylammonium fluoride (TBAF) in THF (1 M, 0.5 mL, 0.5 mmol) was added. The reaction mixture was stirred at room temperature for 162 hours and then concentrated under reduced pressure. The resulting crude product was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound 2113 ((3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-36-(triazol-1-yl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (4.6 mg, 84% through two steps). The LC/MS data are as described in Table 22. 
     Synthesis of Compound 2115 ((3S,9S,18S,21S,25S,28S,34S,36S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-36-(triazol-1-yl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 2115 ((3S,9S,18S,21S,25S,28S,34S,36S)-3-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-9-(cyclopentylmethyl)-21-isobutyl-28-isopropyl-7,10,13,16,22,26,29-heptamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-36-(triazol-1-yl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (8.0 mg) was obtained by the same method as in the synthesis of Compound 2113 using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) as a starting material for peptide synthesis according to the basic peptide synthesis method described in the present Examples, and using (2S,4S)-4-azido-1-Fmoc-pyrrolidine-2-carboxylic acid (Fmoc-L-Pro(4-N3)-OH(2S,4S), CAS No. 263847-08-1) as an Fmoc amino acid. The LC/MS data are as described in Table 22. 
     1-4-6. Peptide Modification by Suzuki Coupling 
     Synthesis of Compound 2096 ((3S,9S,18S,21S,25S,28S,31S,34S)-31-benzyl-9-[(4-chlorophenyl)methyl]-3-[2-[2-fluoro-4-(trifluoromethyl)phenyl]ethyl]-28-isobutyl-7,10,13,16,21,22,29,32-octamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 2096-a (157 mg) was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa018-resin ((3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-pyrrolidin-1-ylbutanoic acid-2-chlorotrityl resin (Fmoc-Asp(O-Trt(2-Cl)-resin)-pyrro)) as a raw material. 
     LCMS (ESI) m/z=1273.3 (M−H)− 
     Retention time: 0.74 min (analysis condition SQDFA05) 
     To a mixed solution of Compound 2096-a (15 mg, 0.012 mmol), thallium carbonate (55.1 mg, 0.118 mmol), and RuPhos Pd G4 (CAS No. 1599466-85-9, 30 mg, 0.035 mmol) in water/THF (1/10, 0.235 mL) was added 1-(bromomethyl)-2-fluoro-4-(trifluoromethyl)benzene (24.2 mg, 0.094 mmol) under a nitrogen atmosphere, and the mixture was then stirred at 70° C. for 18 hours. The reaction solution was filtered through celite and then purified by reverse phase column chromatography (C18, methanol/10 mM aqueous ammonium acetate and 0.3% formic acid/acetonitrile/water) to give Compound 2096 ((3S,9S,18S,21S,25S,28S,31S,34S)-31-benzyl-9-[(4-chlorophenyl)methyl]-3-[2-[2-fluoro-4-(trifluoromethyl)phenyl]ethyl]-28-isobutyl-7,10,13,16,21,22,29,32-octamethyl-18-[(1S)-1-methylpropyl]-25-(pyrrolidine-1-carbonyl)-1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-2,5,8,11,14,17,20,23,27,30,33-undecone) (14.1 mg, 71%). The LC/MS data are as described in Table 22. 
     Synthesis of Compounds 2093, 2091, 2087, 2094, 2086, 2089, 2092, 2090, 2088, and 2095 
     Compound 2093-a (312 mg) was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa138-resin ((3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid-2-chlorotrityl resin, Fmoc-D-3-Abu-O-Trt(2-Cl)resin) as a raw material. 
     LCMS (ESI) m/z=1188.4 (M−H)— (detected as dehydrated form) 
     Retention time: 2.84 min (analysis condition SQDFA30long50deg) 
     
       
         
         
             
             
         
       
     
     Compound 2093, 2091, 2087, 2094, 2086, 2089, 2092, 2090, 2088, and 2095 were obtained by the same synthesis method as in Compound 2096 using Compound 2093-a as a raw material and using a benzyl bromide provided below (8 equivalents relative to the raw material peptide). The following table describes target compound peptides, benzyl bromides used for reactions, and yield amounts (mg) and yield percentages (%) of the target compounds. The LC/MS data are as described in Table 22. 
                                 TABLE 17               Target       Yield   Yield       compound   Benzyl bromide   mg   %                                                Compound 2093   1-(bromomethyl)-3-fluoro-4-   5.6   34           (trifluoromethyl)benzene       Compound 2091   1-(bromomethyl)-2,3,4,5,6,-   9   54           pentafluorobenzene       Compound 2087   1-(bromomethyl)-2,4,5-   5.3   33           trifluorobenzene       Compound 2094   2-(bromomethyl)-4-chloro-1-   5.8   35           fluorobenzene       Compound 2086   1-(bromomethyl)-4-chloro-2-   2.6   16           fluorobenzene       Compound 2089   1-(bromomethyl)-2,4-   1.7   11           difluorobenzene       Compound 2092   2-(bromomethyl)-1-chloro-3-   0.7   4.6           fluorobenzene       Compound 2090   2-(bromomethyl)-1,3,5-   7   43           trifluorobenzene       Compound 2088   4-(bromomethyl)-2-chloro-1-   3.8   22           (trifluoromethyl)benzene       Compound 2095   1-(bromomethyl)-3-   1.4   8.8           (trifluoromethyl)benzene                    
1-4-6. Peptide modification by Chan-Lam-Evans coupling
 
     The following table shows structural formulas of 2,4,6-triarylboroxane-pyridine complexes used for reactions corresponding to target compounds. These 2,4,6-triarylboroxane-pyridine complexes were synthesized with reference to J. Org. Chem. 2004, 69, 5087-5092. 
     
       
         
           
               
               
             
               
                 TABLE 18 
               
               
                   
               
               
                 Target compound 
                 2,4,6-triarylboroxane-pyridine complex 
               
               
                   
               
             
            
               
                 Compound 2040 Compound 2042 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 Compound 2039 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 Compound 2041 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 Compound 2114 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     Synthesis of Compound 2040 ((3S,9S,18S,21S,25S,28S,34S′)-3-[2-(4-chlorophenoxy)ethyl]-cyclohexyl-9-(cyclohexylmethl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     
       
         
         
             
             
         
       
     
     To a mixture of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-hydroxybutanoic acid (Fmoc-Hse-OH) (2.56 g, 7.5 mmol) in THF (15 mL) were added PPTS (94 mg, 0.375 mmol) and 3,4-dihydropyran (4.75 mL, 52.5 mmol), and the mixture was stirred at 50° C. for 16 hours. Ethyl acetate was added to the reaction solution, which was washed with brine three times. The organic layer was dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to give a mixture of Compound 2040-a with a compound having a carboxylic acid converted to THP. The resulting crude product was used for the next reaction without further purification. 
     The total amount of the crude product obtained above was dissolved in THF (30 mL), an aqueous disodium hydrogenphosphate solution (1 M, 30 mL) was added, and the mixture was stirred at 50° C. for four hours. The reaction solution was extracted with ethyl acetate, the organic layer was washed with brine and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give Compound 2040-a (3.6 g, quant.). The resulting crude product was used for the next reaction without further purification. 
     LCMS (ESI) m/z=448 (M+Na)+ 
     Retention time: 0.82 min (analysis condition SQDFA05) 
     Compound 2040-b (410 mg) was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (1.6 g) as a raw material and using the above-obtained Compound 2040-a as an Fmoc amino acid. 
     LCMS (ESI) m/z=1238.1 (M−H)− 
     Retention time: 0.81 min (analysis condition SQDFA05) 
     To a solution of Compound 2040-b (15 mg, 0.012 mmol) in 1,2-dichloroethane (225 μL, 0.05 mol/L) were added DIPEA (8 equivalents), copper(II) acetate (4 equivalents), 2,4,6-triarylboroxane-pyridine complex (1.7 equivalents), and molecular sieves 4A (3.3 w/w), and the mixture was then reacted at room temperature overnight under an oxygen atmosphere. The reaction solution was concentrated and then partially purified by reverse phase column chromatography (C18, methanol/10 mM aqueous ammonium acetate solution). The resulting residue was purified by preparative HPLC to give Compound 2040 ((3S,9S,18S,21S,25S,28S,34S)-3-[2-(4-chlorophenoxy)ethyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (3.3 mg, 22%). The LC/MS data are as described in Table 22. 
     Synthesis of Compound 2039 ((3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-(3,4-dichlorophenoxy)ethyl]-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 2039 ((3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-3-[2-(3,4-dichlorophenoxy)ethyl]-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (1.3 mg, 7.5%) was obtained by the same method as in the synthesis of Compound 2040 using Compound 2040-b (15 mg, 0.012 mmol) as a raw material. The LC/MS data are as described in Table 22. 
     Synthesis of Compound 2041 ((3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[2-[4-(trifluoromethyl)phenoxy]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 2041 ((3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1l-carbonyl)-3-[2-[4-(trifluoromethyl)phenoxy]ethyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (2.1 mg, 13%) was obtained by the same method as in the synthesis of Compound 2040 using Compound 2040-b (15 mg, 0.012 mmol) as a raw material. The LC/MS data are as described in Table 22. 
     Synthesis of Compound 2042 ((3S,9S,18S,21S,25S,28S,34S)-3-[(4-chlorophenoxy)methyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1l-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undeconeC) 
     
       
         
         
             
             
         
       
     
     Compound 2042-a (230 mg) was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (1.6 g) as a raw material. 
     LCMS (ESI) m/z=1224.1 (M+H)+ 
     Retention time: 0.82 min (analysis condition SQDFA05) 
     Compound 2042 ((3S,9S,18S,21S,25S,28S,34S)-3-[(4-chlorophenoxy)methyl]-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (2.56 mg, 16%) was obtained by the same method as in the synthesis of Compound 2040 using Compound 2042-a (15 mg, 12 μmol) as a raw material. The LC/MS data are as described in Table 22. 
     Synthesis of Compound 2114 ((6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-22-(phenoxymethyl)-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 2114-a (60 mg, 36%) was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (0.4 g, 0.3 mmol/g, 0.12 mmol) as a raw material. 
     LCMS (ESI) m/z=1409.6 (M+H)+ 
     Retention time: 0.92 min (analysis condition SQDFA05) 
     Compound 2114 ((6S,9S,13S,16S,22S,25S,31S,34S)-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-4,10,14,19,19,20,29,32-octamethyl-6-[(1S)-1-methylpropyl]-22-(phenoxymethyl)-13-(piperidine-1-carbonyl)-31-(p-tolylmethyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-2,5,8,11,15,18,21,24,27,30,33-undecone) (1.53 mg, 29%) was obtained by the same method as in the synthesis of Compound 2040 using Compound 2114-a (5 mg, 3.55 μmol) as a raw material. The LC/MS data are as described in Table 22. 
     1-4-7. Peptide Synthesis Through N-Alkylation by Mitsunobu Reaction on Resins 
     Synthesis of Compound 2161 ((8S,11S,17S,26S,29S,33S,36S)-8-[(2-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-9-ethyl-36-isopropyl-15,18,21,24,29,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) 
     Compound 2161 was synthesized according to the following route. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     
       
         
         
             
             
         
       
     
     Compound 2161-a-resin was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (100 mg, 0.462 mmol/g, 0.0462 mmol) as a raw material. 
     To the above-obtained Compound 2161-a-resin were added a nosyl chloride/THF solution (0.2 mmol, 0.35 mL) and a collidine/THF solution (0.5 mmol, 0.35 mL), and the mixture was shaken at 40° C. for two hours. Thereafter, the resin was washed with THF (0.7 mL) four times and then washed with DCM (0.7 mL) four times to give Compound 2161-b-resin. The obtained resin was partially cleaved with TFE/DCM (1/1) and analyzed by LC/MS to confirm the progress of the reaction. 
     LCMS (ESI) m/z=805 (M+H)+ 
     Retention time: 0.79 min (analysis condition SQDFA05) 
     The above-obtained Compound 2161-b-resin was swollen with DCM (1.0 mL) and washed with THF (0.7 mL) four times, after which a triphenylphosphine/THF solution (66.0 mg/0.7 mL, 0.25 mmol), ethanol (0.024 mL, 0.41 mmol), and diisopropyl azodicarboxylate (DIAD) (0.05 mL, 0.26 mmol) were added and the mixture was shaken at 40° C. for 30 minutes. Thereafter, the resin was washed with THF (0.7 mL) four times and then washed with DCM (0.7 mL) four times to give Compound 2161-c-resin. The obtained resin was partially cleaved with TFE/DCM (1/1) and analyzed by LC/MS to confirm the progress of the reaction. 
     LCMS (ESI) m/z=833 (M+H)+ 
     Retention time: 0.88 min (analysis condition SQDFA05) 
     The above-obtained Compound 2161-c-resin was swollen with DCM (1.0 mL) and washed with NMP (0.7 mL) four times, after which a DBU/NMP solution (36 μL/314 μL) and a 1-dodecanethiol/NMP solution (89 μL/261 μL) were added and the mixture was shaken at 40° C. for one hour. Thereafter, the resin was washed with NMP (0.7 mL) four times and then washed with DCM (0.7 mL) four times to give Compound 2161-d-resin. The obtained resin was partially cleaved with TFE/DCM (1/1) and analyzed by LC/MS to confirm the progress of the reaction. 
     LCMS (ESI) m/z=648 (M+H)+ 
     Retention time: 0.51 min (analysis condition SQDFA05) 
     Peptide chain elongation and cyclic peptide synthesis were conducted according to the basic route using the above-obtained Compound 2161-d-resin to give Compound 2161 ((8S,11S,17S,26S,29S,33S,36S)-8-[(2-chlorophenyl)methyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-17-(cyclohexylmethyl)-9-ethyl-36-isopropyl-15,18,21,24,29,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) (5.5 mg, 8%). The LC/MS data are as described in Table 22. 
     Synthesis of Compounds 2162-2167 
     Compounds 2162-2167 were synthesized in the same manner as in the synthesis of Compound 2161. The LC/MS data are as described in Table 22. 
     Synthesis of Compounds 2168-2171 
     Compounds 2168-2171 were synthesized according to the basic scheme provided below in the same manner as in the synthesis of Compound 2161 using methanol (0.019 mL, 0.47 mmol) instead of ethanol in Mitsunobu reaction. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     The Fmoc amino acid having a pyridine ring on the side chain, as used for synthesizing Compound 2169, was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
     
     A mixture of Compound 2169-a synthesized according to the method described in WO 2018/225864 (5 g, 13.47 mmol), zinc powder (2.63 g, 40.46 mmol), and iodine (515 mg, 2.03 mmol) in DMF (15 mL) was stirred at room temperature for two hours under a nitrogen atmosphere. To the solution were added 5-bromopyridine-2-carbonitrile (3.19 g, 17.43 mmol), tris(dibenzylideneacetone)(chloroform)dipalladium (0), (350 mg, 0.34 mmol), and 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (Xphos) (321 mg, 0.67 mmol) were added, and the mixture was stirred at 50° C. for three hours. The reaction solution was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give Compound 2169-b (2.5 g, 53%). This was mixed with another lot synthesized in the same manner and was used for the next reaction. 
     LCMS (ESI) m/z=348 (M+H)+ 
     Retention time: 1.508 min (analysis condition SMDmethod23) 
     A solution of Compound 2169-b (12 g, 34.54 mmol) in dichloromethane (100 mL) was stirred at 25° C. for two hours while bubbling with hydrochloric acid gas. The precipitated solid was collected by filtration to give Compound 2169-c as a crude product (7.83 g, 100%). This was used for the next reaction without further purification. 
     To a solution of Compound 2169-c (2.4 g, 10.54 mmol) and potassium carbonate (3.77 g, 27.28 mmol) in water (34 mL) was added a solution of Fmoc-OSu (3.06 g, 10.54 mmol) in 1,4-dioxane (34 mL), and the mixture was stirred at 0° C. for one hour. The reaction solution was diluted with water and washed with diethyl ether three times. The resulting aqueous layer was adjusted to a pH range of 5 to 6 and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (dichloromethane/methanol) to give Compound 2169-d (1 g, 23%). 
     LCMS (ESI) m/z=414.2 (M+H)+ 
     Retention time: 2.737 min (analysis condition SMDmethod_22) 
     Compound 2170 was synthesized using, as an Fmoc amino acid, 9H-fluoren-9-ylmethoxycarbonylamino-3-[3-fluoro-4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acid (Fmoc-Tyr(3-F,tBu)-OH) synthesized as described in WO 2018/225864. The phenol tBu group was deprotected by adding 2 mL of a 0.1 M tetramethylammonium bisulfate/1,1,1,3,3,3-hexafluoroisopropyl alcohol (HFIP) solution containing 2% triisopropylsilane (TIPS) to the residue after cyclization reaction, and allowing to stand at room temperature for 24 hours. 
     1-4-8. Peptide Synthesis Through Amination on Resins 
     Synthesis of Compound 2035 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(2,2-difluorospiro[3.3]heptan-6-yl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Fmoc-MeChg-OH and then Fmoc-cLeu-OH were elongated and the Fmoc group was deprotected by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (100 mg, 0.437 mmol/g, 0.0437 mmol) as a raw material, after which Compound 2035-a-resin with the peptide N-terminus iodinated on the resin was obtained using a mixture composed of a solution of iodoacetic acid (0.6 mol/L, 0.3 mL) in NMP/DMF (1/1) and a solution of diisopropylcarbodiimide (DIC) in N,N-dimethylformamide (DMF) (10% v/v, 0.36 mL). Further, this was reacted with 6,6-difluorospiro[3.3]heptan-2-amine hydrochloride in the presence of DIPEA to give Compound 2035-b-resin. Subsequent peptide chain elongation and cyclic peptide synthesis were conducted according to the basic route to give Compound 2035 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(2,2-difluorospiro[3.3]heptan-6-yl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) (4.12 mg, 6%). The LC/MS data are as described in Table 22. 
     Synthesis of Compounds 2031, 2030, 2022, 2021, 2036, 2025, 2024, 2029, 2032, 2033, 2026, 2023, 2028, 2027, and 2034 
     Tripeptide-loaded resins were synthesized by the same method as in the synthesis of Compound 2035, iodoacetic acids were then condensed and aminated, and peptide chain elongation and cyclic peptide synthesis were further conducted according to the basic route to synthesize Compounds 2031, 2030, 2022, 2021, 2036, 2025, 2024, 2029, 2032, 2033, 2026, 2023, 2028, 2027, and 2034. The following table describes target compound peptides, amines used for reactions, and yield amounts (mg) of the target compounds. The LC/MS data are as described in Table 22. 
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 19 
               
               
                   
                   
               
               
                   
                 Peptide 
                 Amine 
                 Yield mg 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Compound 2031 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 5.09 
               
               
                   
                   
               
               
                   
                 Compound 2030 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2.76 
               
               
                   
                   
               
               
                   
                 Compound 2022 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 10.32 
               
               
                   
                   
               
               
                   
                 Compound 2021 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8.99 
               
               
                   
                   
               
               
                   
                 Compound 2036 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 5.06 
               
               
                   
                   
               
               
                   
                 Compound 2025 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8.11 
               
               
                   
                   
               
               
                   
                 Compound 2024 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2.99 
               
               
                   
                   
               
               
                   
                 Compound 2029 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 18.06 
               
               
                   
                   
               
               
                   
                 Compound 2032 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 16.68 
               
               
                   
                   
               
               
                   
                 Compound 2033 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 9.24 
               
               
                   
                   
               
               
                   
                 Compound 2026 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 14.51 
               
               
                   
                   
               
               
                   
                 Compound 2023 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3.39 
               
               
                   
                   
               
               
                   
                 Compound 2028 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4.78 
               
               
                   
                   
               
               
                   
                 Compound 2027 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 5.34 
               
               
                   
                   
               
               
                   
                 Compound 2034 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4.99 
               
               
                   
                   
               
            
           
         
       
     
     Synthesis of Compound 2037 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(2-hydroxyethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) and Compound 2038 (2-[2-[(11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-9-yl]ethoxyl-N,N-dimethyl-acetamide) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Compound 2037 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(2-hydroxyethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) was obtained by the same method as in the synthesis of Compound 2035 using Compound 2035-a-resin and using 2-(2-aminoethoxy)oxane as an amine, and by conducting peptide chain elongation, and cyclic peptide synthesis including THP deprotection, according to the basic route. The LC/MS data are described in Table 22. 
     Compound 2038 (2-[2-[11(1S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(Trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[1(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[14.33]octatriacontan-9-yl]ethoxy]-N,N-dimethyl-acetamide) (4.7 mg, 89%) was obtained by the same method as in the synthesis of Compound 2116 using Compound 2037 (5 mg, 3.46 μmol), silver oxide (24.0 mg, 0.104 mmol), and 2-bromo-N,N-dimethylacetamide (17.2 mg, 0.104 mmol). The LC/MS data are described in Table 22. 
     1-4-9. Peptide Modification by Amidation of Carboxylic Acids 
     Synthesis of Compound 2108 (3-[(3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(morpholine-4-carbonyl)-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-22-yl]-N,N-dimethyl-propanamide) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Compound 2108-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-5-oxo-5-prop-2-enoxypentanoic acid) was obtained as a crude product (2.179 g, 96%) by the same method as in the synthesis of Compound aa078-b using (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-prop-2-enoxypentanoic acid (Fmoc-Glu(OAl)—OH) (2.197 g, 5.37 mmol) as a starting material. 
     LCMS (ESI) m/z=424 (M+H)+ 
     Retention time: 0.84 min (analysis condition SQDFA05) 
     Compound 2108-b was obtained as a crude product by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa007-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-morpholin-4-yl-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-mor) (0.424 mmol/g, 600 mg, 0.254 mmol) as a starting material and using Compound 2108-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-5-oxo-5-prop-2-enoxypentanoic acid) as a reagent. 
     The total amount of Compound 2108-b obtained above (0.254 mmol) was dissolved in dichloromethane (2.5 mL), tetrakistriphenylphosphinepalladium (14.7 mg, 0.05 equiv.) and phenylsilane (22 μL, 0.7 equiv.) were added, and the mixture was stirred at room temperature for 75 minutes. Tetrakistriphenylphosphinepalladium (14.7 mg, 0.05 equiv.) and phenylsilane (22 L, 0.7 equiv.) were added to the reaction solution, and the mixture was stirred for 90 minutes to give a reaction solution containing Compound 2108-c. A solution of HATU (193 mg, 2 equiv.) in dimethylformamide (2.5 mL), and diisopropylethylamine (0.11 mL, 2.4 equiv.) were added thereto, and the mixture was stirred for 15 minutes. This reaction solution (Reaction Solution A) was divided into six portions, one of which was used for the subsequent reaction. 
     Dimethylamine (0.11 mL, 5 equiv., 2.0 M tetrahydrofuran solution) was added to Reaction Solution A (0.0424 mmol), and the mixture was stirred at room temperature for 30 minutes. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by preparative HPLC to give Compound 2108 (3-[(3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-3,4,10,14,17,23,29,32-octamethyl-6-[(1S)-1-methylpropyl]-13-(morpholine-4-carbonyl)-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-22-yl]-N,N-dimethyl-propanamide) (3.6 mg, 5.6%). The LC/MS data are described in Table 22. 
     Synthesis of Compounds 2098, 2103, 2112, 2104, and 2107 
     Compound 2098, 2103, 2112, 2104, or 2107 was obtained by adding an amine (5 equiv. relative to the peptide) shown in the following table instead of dimethylamine to one of the six divided portions of Reaction Solution A as obtained in the synthesis of Compound 2108, by the same method as in the synthesis of Compound 2108. The following table describes target compound peptides, amines used for reactions, and yield amounts (mg) and yield percentages (%) of the target compounds. The LC/MS data are described in Table 22. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 20 
               
               
                   
               
               
                   
                   
                 Yield  
                 Yield  
               
               
                 Peptide  
                 Amine  
                 mg  
                 % 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Compound 2098  
                 3,3-difluoroazetidine-hydrochloride  
                 2.7  
                 4  
               
               
                 Compound 2103  
                 azetidine  
                 3.6  
                 5.5  
               
               
                 Compound 2112  
                 piperidine  
                 3.8  
                 5.7  
               
               
                 Compound 2104  
                 pyrrolidine  
                 2.5  
                 3.8  
               
               
                 Compound 2107  
                 morpholine  
                 4.5  
                 6.8 
               
               
                   
               
            
           
         
       
     
     Synthesis of Compound 2106 ((3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(dimethylamino)-2-oxo-ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide) 
     
       
         
         
             
             
         
       
     
     Compound 2106-a was obtained as a crude product by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa011-resin ((3S)-4-(dimethylamino)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-NMe2) (600 mg, 0.371 mmol/g, 0.223 mmol) as a starting material and using Compound 2108-a ((2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-5-oxo-5-prop-2-enoxypentanoic acid) as a reagent. 
     The total amount of Compound 2106-a obtained above (0.223 mmol) was dissolved in dichloromethane (2.5 mL), tetrakis(triphenylphosphine)palladium(0) (14.7 mg, 0.05 equiv.) and phenylsilane (22 μL, 0.7 equiv.) were added thereto, and the mixture was stirred at room temperature for one hour. Tetrakis(triphenylphosphine)palladium (0) (14.7 mg, 0.05 equiv.) and phenylsilane (22 μL, 0.7 equiv.) were added to the reaction solution, and the mixture was stirred for two hours to give a reaction solution containing Compound 2106-b. A solution of HATU (193 mg, 2 equiv.) in dimethylformamide (2.5 mL) and diisopropylethylamine (0.11 mL, 2.4 equiv.) were added to the reaction solution, and the mixture was stirred for 15 minutes. This reaction solution (Reaction Solution B) was divided into six portions, one of which was used for the subsequent reaction. 
     Dimethylamine (0.11 mL, 5 equiv., 2.0 M tetrahydrofuran solution) was added to Reaction Solution B (0.037 mmol), and the mixture was stirred at room temperature for two hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by preparative HPLC to give Compound 2106 ((3S,6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-22-[2-(dimethylamino)-2-oxo-ethyl]-9-isobutyl-N,N,3,4,10,14,17,23,29,32-decamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide) (6.6 mg, 12%). The LC/MS data are described in Table 22. 
     Synthesis of Compounds 2102, 2105, 2097, and 2109 
     Compound 2102, 2105, 2097, or 2109 was obtained by adding an amine (5 equiv. relative to the peptide) shown in the following table instead of dimethylamine to one of the six divided portions of Reaction Solution B as obtained in the synthesis of Compound 2106, by the same method as in the synthesis of Compound 2106. The following table describes target compound peptides, amines used for reactions, and yield amounts (mg) and yield percentages (%) of the target compounds. The LC/MS data are described in Table 22. 
     
       
         
           
               
               
               
               
               
             
               
                   
                 TABLE 21 
               
               
                   
                   
               
               
                   
                 Target 
                   
                 Yield 
                 Yield 
               
               
                   
                 compound 
                 Amine 
                 mg 
                 % 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Compound 2102 
                 azetidine 
                 6.3 
                 11 
               
               
                   
                 Compound 2105 
                 piperidine 
                 5.6 
                 10 
               
               
                   
                 Compound 2097 
                 pyrrolidine 
                 4.4 
                 8 
               
               
                   
                 Compound 2109 
                 morpholine 
                 9.2 
                 16 
               
               
                   
                   
               
            
           
         
       
     
     Synthesis of Compound 2110 (3-[(3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-22-butyl-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,20,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontan-19-yl]-N,N-dimethyl-propanamide) 
     
       
         
         
             
             
         
       
     
     A solution of Compound 2108-a (10.34 g, 24.42 mmol), WSCI—HCl (6.09 g, 31.7 mmol), and HOAt (4.32 g, 31.7 mmol) in DCM (116 mL) was stirred at room temperature for 15 minutes, methanol (1.038 mL, 25.6 mmol) and DIPEA (5.53 mL, 31.7 mmol) were added thereto, and the mixture was stirred for 90 minutes. The reaction solution was diluted with dichloromethane and sequentially washed with saturated aqueous ammonium chloride/water (1/1) and brine. The organic layer was dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to give Compound 2110-a as a crude product (10.93 g). This was mixed with another lot synthesized by the same method and was used for the next reaction. 
     LCMS (ESI) m/z=438 (M+H)+ 
     Retention time: 1.338 min (analysis condition SMDmethod_04) 
     Tetrakis(triphenylphosphine)palladium(0) (0.19 g, 0.164 mmol) and phenylsilane (2.359 mL, 19.18 mmol) were added to a solution of Compound 2110-a (11.99 g, 27.4 mmol) in DCM (54.8 mL) at 0° C. under a nitrogen atmosphere, and the mixture was stirred at room temperature overnight. The reaction solution was diluted with TBME and washed with a 5% aqueous sodium carbonate solution and water. The aqueous layer was acidified with phosphoric acid (11.25 mL, 164 mmol) and extracted with ethyl acetate. The resulting organic layer was washed with brine and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to give Compound 2110-b (9.56 g, 95%). 
     LCMS (ESI) m/z=420 (M+Na)+ 
     Retention time: 1.069 min (analysis condition SMDmethod_04) 
     A solution of 2-phenylpropan-2-yl 2,2,2-trichloroacetimidate (13.5 g, 48.1 mmol) in DCM/cyclohexane (1/1, 32.8 mL) was added to a solution of Compound 2110-b (9.56 g, 24.05 mmol) in DCM (16.04 mL) at room temperature, and the mixture was stirred overnight. The reaction solution was filtered through celite, and the solvent was evaporated from the filtrate under reduced pressure to give Compound 2110-c as a crude product (17.29 g). This was used for the next reaction without further purification. 
     A solution of Compound 2110-c (17.29 g) in THF (100 mL) and 2-propanol (401 mL) was added to a suspension of calcium chloride (40 g, 361 mmol) and lithium hydroxide monohydrate (4.04 g, 96 mmol) in water (100 mL) at room temperature, and the mixture was stirred overnight. The solid in the reaction solution was removed by filtration, and the filtrate was concentrated under reduced pressure. Water was added to the residue, and the mixture was extracted with ethyl acetate. The organic layer was sequentially washed with a 0.1 M aqueous phosphoric acid solution and brine and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was diluted with TBME/hexane (1/1) and extracted with 5% aqueous sodium carbonate/water/methanol (15/12/4). The resulting aqueous layer was washed with TBME/hexane (1/1) and extracted with ethyl acetate. The resulting organic layer was sequentially washed with a 0.2 M aqueous phosphoric acid solution and brine and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give Compound 2110-d (9.68 g, 80%). 
     LCMS (ESI) m/z=524 (M+Na)+ 
     Retention time: 1.365 min (analysis condition SMDmethod_04) 
     Compound 2110-e (25 mg, 40%) was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (100 mg, 0.411 mmol/g, 0.0411 mmol) as a raw material and using the above-obtained Compound 2110-d as a reagent. The Pis group was deprotected under the same conditions as in the deprotection of the THP group. 
     LCMS (ESI) m/z=1510 (M+H)+ 
     Retention time: 0.71 min (analysis condition SQDAA50) 
     Compound 2110-e (15 mg, 0.0099 mmol) was dissolved in tetrahydrofuran (0.2 ml). Sodium bicarbonate (4.17 mg, 0.050 mmol), 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT) (14.87 mg, 0.050 mmol), and Dimethylamine (2 mol/L, a THF solution, 0.025 ml, 0.050 mmol) were added, and the mixture was then stirred at room temperature for four hours. The reaction solution was concentrated, and the resulting residue was then purified by preparative HPLC to give Compound 2110 (3-[(3S,6S,9S,13S,16S,19S,22S,25S,31S,34S)-22-butyl-25-[(3-iodophenyl)methyl]-9,16-diisobutyl-31-[(4-methoxyphenyl)methyl]-3,4,10,14,20,29,32-heptamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-13-(piperidine-1-carbonyl)-1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontan-19-yl]-N,N-dimethyl-propanamide) (5.07 mg, 33%). The LC/MS data are described in Table 22. 
     Synthesis of Compound 2100 (3-[(3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-34-(piperidine-1-carbonyl)-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-6-yl]-N,N-dimethyl-propanamide) 
     
       
         
         
             
             
         
       
     
     Compound 2100-a (27.5 mg, 46%) was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (100 mg, 0.411 mmol/g, 0.0411 mmol) as a raw material and using Compound 2110-d as a reagent. The Pis group was deprotected under the same conditions as in the deprotection of the THP group. 
     LCMS (ESI) m/z=1468 (M+H)+ 
     Retention time: 0.73 min (analysis condition SQDAA50) 
     Compound 2100 (3-[(3S,6S,9S,12S,18S,27S,30S,34S)-9-butyl-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-1,7,16,19,22,25,31-heptamethyl-27-[(1S)-1-methylpropyl]-2,5,8,11,14,17,20,23,26,29,32-undecaoxo-34-(piperidine-1-carbonyl)-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacont-6-yl]-N,N-dimethyl-propanamide) (6.44 mg, 43%) was obtained by the same method as in the synthesis of Compound 2110 using Compound 2100-a. The LC/MS data are described in Table 22. 
     Synthesis of Compound 2101 ((3S,9S,12S,18S,27S,30S,34S)-34-(4,4-difluoropiperidine-1-carbonyl)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-9-[(4-methoxyphenyl)methyl]-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     2-Phenylpropan-2-yl 2,2,2-trichloroacetimidate (2.74 g, 9.77 mmol) was added as a DCM solution to a solution of aa033-b (2 g, 4.88 mmol) in DCM (15 mL), and the mixture was stirred at room temperature for two hours. The solvent was evaporated from the reaction solution under reduced pressure, and the resulting residue was purified by reverse phase column chromatography to give Compound 2101-a (2.10 g, 81° %). 
     LCMS (ESI) m/z=550.3 (M+Na)+ 
     Retention time: 0.76 min (analysis condition SQDAA50) 
     Tetrakis(triphenylphosphine)palladium(0) (0.046 g, 0.04 mmol) and phenylsilane (0.343 mL, 2.79 mmol) were added to a solution of Compound 2101-a (2.1 g, 3.98 mmol) in DCM (15 mL) at room temperature under a nitrogen atmosphere, and the mixture was stirred for one hour. The reaction solution was diluted with MTBE and a 5% aqueous sodium bicarbonate solution, the solvent was evaporated under reduced pressure, and the resulting residue was purified by reverse phase column chromatography to give Compound 2101-b (1.67 g, 86%). 
     LCMS (ESI) m/z=510 (M+Na)+ 
     Retention time: 0.94 min (analysis condition SQDFA05) 
     Compound 2101-b-resin (3.6 g, 0.377 mmol/g) was obtained by the same method as in the synthesis of Compound aa007-resin using the obtained Compound 2101-b (1.17 g, 2.4 mmol). 
     Compound 2101-c (38 mg, 24%) was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound 2101-b-resin (300 mg, 0.377 mmol/g, 0.1131 mmol) as a raw material. The Pis group was deprotected under the same conditions as in the deprotection of the THP group. 
     LCMS (ESI) m/z=1421 (M+H)+ 
     Retention time: 0.64 min (analysis condition SQDAA50) 
     Compound 2101 ((3S,9S,12S,18S,27S,30S,34S)-34-(4,4-difluoropiperidine-1-carbonyl)-12-1[(3-iodophenyl)methyl]-3,30-diisobutyl-9-[(4-methoxyphenyl)methyl]-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone) (6.77 mg, 42%) was obtained by the same method as in the synthesis of Compound 2110 using Compound 2101-c (15 mg, 10.56 μmol) and using 4,4-difluoropiperidine hydrochloride instead of dimethylamine. The LC/MS data are described in Table 22. 
     Synthesis of Compound 2099 ((3S,9S,12S,18S,27S,30S,34S)-34-(3,3-difluoropiperidine-1-carbonyl)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-9-[(4-methoxyphenyl)methyl]-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 2099 ((3S,9S,12S,18S,27S,30S,34S)-34-(3,3-difluoropiperidine-1-carbonyl)-12-[(3-iodophenyl)methyl]-3,30-diisobutyl-9-[(4-methoxyphenyl)methyl]-1,6,6,7,16,19,22,25,31-nonamethyl-27-[(1S)-1-methylpropyl]-18-(p-tolylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone) (5.24 mg, 33%) was obtained by the same method as in the synthesis of Compound 2110 using Compound 2101-c (15 mg, 10.56 μmol) and using 3,3-difluoropiperidine hydrochloride instead of dimethylamine. The LC/MS data are described in Table 22. 
     1-4-10. Peptide Modification by Olefin Metathesis Reaction 
     Synthesis of Compound 2053 ((8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-(2-tetrahydropyran-4-ylideneethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) 
     
       
         
         
             
             
         
       
     
     A solution of Compound 1449 (9 mg, 6.18 μmol), Grubbs catalyst 2nd generation (2.6 mg), and 4-methylenetetrahydro-2H-pyran (20 μL) in 1,2-dichloroethane (1 mL) was stirred at 60° C. for six hours under a nitrogen atmosphere. 4-Methylenetetrahydro-2H-pyran (50 μL) was further added and the mixture was stirred at the same temperature for 2 hours and 45 minutes. Grubbs catalyst 2nd generation (2.6 mg) was further added and the mixture was stirred at the same temperature for 12 hours. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The resulting crude product was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound 2053 ((8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-(2-tetrahydropyran-4-ylideneethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) (5.0 mg, 60%). The LC/MS data are described in Table 22. 
     Synthesis of Compound 2048 ((8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-(2-tetrahydropyran-4-ylethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) 
     
       
         
         
             
             
         
       
     
     A mixture of Compound 2053 (7.8 mg, 5.11 μmol) and platinum(IV) oxide (1.2 mg, 5.11 μmol) in ethanol (1 mL) was stirred at room temperature for 10 hours under a hydrogen atmosphere, after which platinum(IV) oxide (1.2 mg, 5.11 μmol) was further added and the mixture was stirred at the same temperature for about 17 hours. The reaction mixture was filtered through celite and concentrated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (10 mM aqueous ammonium acetate solution/methanol) to give Compound 2048 ((8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-8-(2-tetrahydropyran-4-ylethyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) (7.8 mg, 99%). The LC/MS data are described in Table 22. 
     Synthesis of Compound 2050 (tert-butyl 3-[2-[(8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-8-yl]ethylidene]azetidine-1-carboxylate) 
     
       
         
         
             
             
         
       
     
     Under a nitrogen atmosphere, a solution of Compound 1449 (9 mg, 6.18 μmol), Hoveyda-Grubbs catalyst 2nd generation (3.9 mg), and 1-tert-butoxycarbonyl-3-methyleneazetidine (20 μL) in dichloroethane (1 mL) was stirred at 60° C. for 2 hours and 30 minutes and then stirred at 75° C. Hoveyda-Grubbs catalyst 2nd generation (3.9 mg) and 1-tert-butoxycarbonyl-3-methylene-azetidine (20 μL) were further added and the mixture was stirred at 80° C. for 14 hours, after which Hoveyda-Grubbs catalyst 2nd generation (3.9 mg) was further added and the mixture was stirred at the same temperature for about 10 hours. The reaction mixture was cooled to room temperature and concentrated under reduced pressure, and the resulting residue was purified by preparative HPLC to give Compound 2050 (tert-butyl 3-[2-[(8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-8-yl]ethylidene]azetidine-1-carboxylate) (0.65 mg, 6.6%). The LC/MS data are described in Table 22. 
     Synthesis of Compound 2056 (tert-butyl 3-[2-[(8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-8-yl]ethyl]azetidine-1-carboxylate) 
     
       
         
         
             
             
         
       
     
     A mixture of Compound 2050 (1.6 mg, 1 μmol) and platinum(IV) oxide (1 mg, 4.4 mol) in ethanol (1 mL) was stirred at room temperature for three hours under a hydrogen atmosphere. The reaction mixture was filtered through celite and concentrated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (10 mM aqueous ammonium acetate solution/methanol) to give Compound 2056 (tert-butyl 3-[2-[(8S,11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9,15,18,21,24,30,34,37-octamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-8-yl]ethyl]azetidine-1-carboxylate) (1.2 mg, 75%). The LC/MS data are described in Table 22. 
     Synthesis of Compound 2046 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(5-hydroxypent-2-enyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 899 (40 mg, 0.028 μmol) was dissolved in 1,2-dichloroethane (0.66 mL), Stewart-Grubbs catalyst (CAS No. 927429-61-6, 24 mg, 0.042 mmol) and homoallyl alcohol (20 μL, 8 equiv.) were added, and the mixture was stirred at room temperature for 16 hours. Homoallyl alcohol (20 μL, 8 equiv.) was further added and the mixture was stirred for two hours, after which Stewart-Grubbs catalyst (CAS No. 927429-61-6, 12 mg, 0.021 mmol) was added and the mixture was further stirred for two hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound 2046 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(5-hydroxypent-2-enyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) (12.3 mg, 30%). The LC/MS data are described in Table 22. 
     Synthesis of Compound 2049 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(5-hydroxypentyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) 
     
       
         
         
             
             
         
       
     
     Platinum(IV) oxide (3.7 mg, 16 μmol) was added to a solution of Compound 2046 (3.0 mg, 2.02 μmol) in ethanol (1.0 mL), the atmosphere in the reaction vessel was replaced with hydrogen, and the mixture was stirred at room temperature for three hours. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by reverse phase column chromatography to give Compound 2049 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(5-hydroxypentyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) (2.6 mg, 87%). The LC/MS data are described in Table 22. 
     Synthesis of Compound 2047 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(4-hydroxy-4-methyl-pent-2-enyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 899 (20 mg, 14 μmol) was dissolved in dichloroethane (0.33 mL), Stewart-Grubbs catalyst (CAS No. 927429-61-6, 12 mg, 21 μmol) and 2-methyl-3-buten-2-ol (12 μL, 8 equiv.) were added, and the mixture was stirred at room temperature for 16 hours. 2-Methyl-3-buten-2-ol (12 μL, 8 equiv.) was further added and the mixture was stirred for 45 minutes, after which Stewart-Grubbs catalyst (CAS No. 927429-61-6, 6.0 mg, 0.8 equiv.) was added and the mixture was stirred for three hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give a crude product. The crude product was purified by preparative HPLC to give Compound 2047 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-9-(4-hydroxy-4-methyl-pent-2-enyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) (1.4 mg, 7%). The LC/MS data are described in Table 22. 
     Synthesis of Compound 2054 (4-[(11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-9-yl]-N,N-dimethyl-but-2-enamide) 
     
       
         
         
             
             
         
       
     
     Compound 2054 (4-[(11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-9-yl]-N,N-dimethyl-but-2-enamide) (1.4 mg, 6%) was obtained by the same synthesis method as in the synthesis of Compound 2047 using Compound 899 (20 mg, 14 μmol) as a starting material and using N,N-dimethylacrylamide (16 equiv.) instead of 2-methyl-3-buten-2-ol. The LC/MS data are described in Table 22. 
     Synthesis of Compound 2052 (4-[(11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-9-yl]-N,N-dimethyl-butanamide) 
     
       
         
         
             
             
         
       
     
     Platinum(IV) oxide (4.7 mg, 10 equiv.) was added to a solution of Compound 2054 (3.1 mg, 2.08 μmol) in ethanol (1.0 mL), the atmosphere in the reaction vessel was replaced with hydrogen, and the mixture was stirred at room temperature for three hours. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by reverse phase column chromatography and then further purified by preparative HPLC to give Compound 2052 (4-[(11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-7,10,13,16,19,22,25,28,31,35,38-undecaoxo-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontan-9-yl]-N,N-dimethyl-butanamide) (1.4 mg, 45%). The LC/MS data are described in Table 22. 
     Synthesis of Compound 2051 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9-[(E)-4-methoxybut-2-enyl]-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 899 (50 mg, 35 μmol) was dissolved in 1,2-dichloroethane (0.69 mL), Stewart-Grubbs catalyst (CAS No. 927429-61-6, 29.7 mg, 1.5 equiv.) and allyl methyl ether (52 μL, 16 equiv.) were added, and the mixture was stirred at room temperature for two hours. Stewart-Grubbs catalyst (CAS No. 927429-61-6, 29.7 mg, 1.5 equiv.) and allyl methyl ether (52 μL, 16 equiv.) were further added, the mixture was stirred for two hours, and the reaction solution was then concentrated under reduced pressure. The resulting residue was purified by reverse phase column chromatography and then further purified by preparative HPLC to give Compound 2051 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-9-[(E)-4-methoxybut-2-enyl]-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) (7.4 mg, 14%). The LC/MS data are described in Table 22. 
     Synthesis of Compound 2055 ((3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-18-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[3-[4-(trifluoromethyl)phenyl]propyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 2055-a (490 mg, 83%) was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(O-Trt(2-Cl)resin)-pip) (1.6 g, 0.3 mmol/g, 0.48 mmol) as a raw material. 
     LCMS (ESI) m/z=1234 (M+H)+ 
     Retention time: 0.93 min (analysis condition SQDFA05) 
     Compound 2055-b was obtained as a crude product by the same method as in Compound 2046 using Compound 2055-a (20 mg, 16 μmol) as a raw material and using 1-(trifluoromethyl)-4-vinylbenzene instead of homoallyl alcohol. The obtained compound 2055-b was dissolved in methanol (3 mL), palladium on carbon (10%) (60 mg) was added, and the mixture was then stirred at room temperature overnight under a hydrogen atmosphere. The reaction solution was concentrated, and the resulting residue was purified by reverse phase column chromatography (10 mM aqueous ammonium acetate solution/water) and then further purified by preparative HPLC to give Compound 2055 ((3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclohexylmethyl)-7,10,13,16,21,22,26,29-octamethyl-8-[(1S)-1-methylpropyl]-25-(piperidine-1-carbonyl)-3-[3-[4-(trifluoromethyl)phenyl]propyl]spiro[1,4,7,10,13,16,19,22,26,29,32-undecazabicyclo[32.3.0]heptatriacontane-31,1′-cyclopentane]-2,5,8,11,14,17,20,23,27,30,33-undecone) (1.92 mg, 8.6%). The LC/MS data are described in Table 22. 
     Synthesis of Compound 1411 ((1S,7S,10S,14S,17S,26S,32S)-32-[(3-iodophenyl)methyl]-7,14-diisobutyl-3,4,4,9,13,19,22,25,28-nonamethyl-17-[(1S)-1-methylpropyl]-10-(piperidine-1-carbonyl)-3,6,9,13,16,19,22,25,28,31,34-undecazabicyclo[24.8.6]tetracontane-2,5,8,12,15,18,21,24,27,30,33-undecone) 
     
       
         
         
             
             
         
       
     
     Compound 1411-a (56.1 mg, 31%) was obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp (0-Trt(2-Cl)resin)-pip) (0.3 g, 0.436 mmol/g, 0.131 mmol) as a raw material. 
     LCMS (ESI) m/z=1372 (M+H)+ 
     Retention time: 0.97 min (analysis condition SQDFA05) 
     Stewart-Grubbs catalyst (CAS No. 927429-61-6, 3.6 mg, 6.3 μmol) was added to a solution of Compound 1411-a (28.7 mg, 21 μmol) in 1,2-dichloroethane (3 mL), and the mixture was stirred at a temperature between 45° C. and 50° C. for five hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by reverse phase column chromatography to give Compound 1411-b (23 mg, 82%). 
     LCMS (ESI) m/z=1344 (M+H)+ 
     Retention time: 0.90 min (analysis condition SQDFA05) 
     Platinum(IV) oxide (4 mg, 18 μmol) was added to a solution of Compound 1411-b (20.2 mg, 15 μmol) in ethanol (1.5 mL), the atmosphere in the reaction vessel was replaced with hydrogen, and the mixture was stirred at room temperature for 90 minutes. The reaction solution was filtered through celite, the filtrate was concentrated under reduced pressure, and the resulting residue was purified by reverse phase column chromatography to give Compound 1411 ((1S,7S,10S,14S,17S,26S,32S)-32-[(3-iodophenyl)methyl]-7,14-diisobutyl-3,4,4,9,13,19,22,25,28-nonamethyl-17-[(1S)-1-methylpropyl]-10-(piperidine-1-carbonyl)-3,6,9,13,16,19,22,25,28,31,34-undecazabicyclo[24.8.6]tetracontane-2,5,8,12,15,18,21,24,27,30,33-undecone) (14 mg, 69%). The LC/MS data are described in Table 22. 
     1-5. Cyclic Peptide Synthesis Using Fmoc-Protected Dipeptides as Reagents Synthesis of Compound 2144-b (2-(N-[(2S)-4-[3-chloro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoyl]anilino)acetic acid) 
     
       
         
         
             
             
         
       
     
     Thionyl chloride (4.32 mL, 59.5 mmol) and DMF (154 μL, 1.985 mmol) were added to a solution of Compound aa132 (10 g, 19.85 mmol) in DCM (397 mL), and the mixture was stirred at room temperature for four days. The solvent was evaporated from the reaction solution under reduced pressure to give an acid chloride (10.95 g), which was used as it is for the next reaction. 
     A solution of tert-butyl 2-anilinoacetate (1.8 g, 8.68 mmol) in DCM (25 mL) was added to a solution of the above-obtained acid chloride (4.76 g, 9.12 mmol) in DCM (65 mL) at 0° C., and the mixture was stirred at room temperature for four hours. Methanol (1.8 mL) and a saturated aqueous ammonium chloride solution were added, and the mixture was extracted with DCM. The resulting organic layer was washed with a saturated aqueous ammonium chloride solution and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure. The resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound 2144-a (4.27 g, 71%). 
     LCMS (ESI) m/z=693.2 (M+H)+ 
     Retention time: 1.18 min (analysis condition SQDFA05) 
     TMSCl (2.307 mL, 18.18 mmol) was added to a solution of Compound 2144-a (4.2 g, 6.06 mmol) in TFE (30.3 mL) at room temperature, and the mixture was stirred. After confirming by LC/MS that the reaction was completed, the reaction solution was concentrated under reduced pressure, and the resulting residue was purified by reverse phase column chromatography (acetonitrile with 0.1% formic acid/distilled water with 0.1% formic acid) to give Compound 2144-b (2-(N-[(2S)-4-[3-chloro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoyl]anilino)acetic acid) (3.795 g, 98%). 
     LCMS (ESI) m/z=637.2 (M+H)+ 
     Retention time: 1.01 min (analysis condition SQDFA05) 
     Synthesis of Compound 2146-b (2-(4-chloro-N-[(2S)-4-[3-chloro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoyl]anilino)acetic acid) 
     
       
         
         
             
             
         
       
     
     Compound 2146-b (2-(4-chloro-N-[(2S)-4-[3-chloro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoyl]anilino)acetic acid) (3.9 g, 97%) was obtained in the same manner as in the synthesis of Compound 2144-b using tert-butyl 2-(3-chloroanilino)acetate instead of N-phenylglycine tert-butyl 2-anilinoacetate. 
     LCMS (ESI) m/z=671.2 (M+H)+ 
     Retention time: 1.05 min (analysis condition SQDFA05) 
     Synthesis of Compound 2147-b (2-(4-chloro-N-[(2S)-4-[3-chloro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoyl]anilino)acetic acid) 
     
       
         
         
             
             
         
       
     
     Compound 2147-b (2-(4-chloro-N-[(2S)-4-[3-chloro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoyl]anilino)acetic acid) (3.21 g, 94%) was obtained in the same manner as in the synthesis of Compound 2144-b using tert-butyl 2-(4-chloroanilino)acetate instead of N-phenylglycine tert-butyl 2-anilinoacetate. 
     LCMS (ESI) m/z=671 (M+H)+ 
     Retention time: 1.06 min (analysis condition SQDFA05) 
     Synthesis of Compound 2149-b (2-[[(2S)-4-[3-chloro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoyl]-thiophen-3-ylamino]acetic acid) 
     
       
         
         
             
             
         
       
     
     Compound 2149-b (2-[[(2S)-4-[3-chloro-4-(trifluoromethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoyl]-thiophen-3-ylamino]acetic acid) (4.3 g, quant.) was obtained in the same manner as in the synthesis of Compound 2144-b using tert-butyl 2-(thiophen-3-ylamino)acetate instead of N-phenylglycine tert-butyl 2-anilinoacetate. 
     LCMS (ESI) m/z=643 (M+H)+ 
     Retention time: 1.00 min (analysis condition SQDFA05) 
     Synthesis of Compounds 2143-2151 
     Compounds 2143-2151 were obtained by peptide synthesis according to the basic peptide synthesis method described in the present Examples, using Compound 2144-b, 2146-b, 2147-b, and 2149-b as reagents. The LC/MS data are described in Table 22. 
     Synthesis of Compound 2180 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-9-[2-(4-methylpiperazin-1-yl)ethyl]-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) 
     Compound 2180 was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Compound aa006-resin ((3S)-3-[19H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(0-Trt(2-Cl)resin)-pip) (100 mg, 0.411 mmol/g, 0.0411 mmol) was used as a raw material, and by subjecting the obtained Compound 2035-a-resin to reaction with 2-(4-methylpiperazin-1-yl)ethanamine hydrochloride (CAS: 401817-30-9) (0.45 mol/L solution in N-methylpyrrolidone, 0.3 mL) in the presence of DIPEA, iodine was substituted with an amino group to give Compound 2180-a-resin. Subsequent peptide chain elongation and cyclic peptide synthesis were performed according to the basic peptide synthesis method to obtain Compound 2180 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-9-[12-(4-methylpiperazin-1-yl)ethyl]-26-[1(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) (6.4 mg, 9%). 
     LCMS (ESI) m/z=1528.3 (M+H)+ 
     Retention time: 0.82 min (analysis condition SQDFA05) 
     Synthesis of Compound 2181 ((3S,6S,9S,13S,16S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-23-[2-[2-(dimethylamino)ethoxy]ethyl]-9-isobutyl-N,N,3,4,10,14,17,29,32-nonamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide) 
     Compound 2181 was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Peptide synthesis according to the basic peptide synthesis method described in the present Example was performed using Compound aa011-resin ((3S)-4-(dimethylamino)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp (0-Trt(2-Cl)resin)-NMe2) (100 mg, 0.456 mmol/g, 0.0456 mmol) as a raw material. Elongation with Fmoc-MeIle-OH and then with Fmoc-cLeu-OH, and deprotection of the Fmoc group were followed by condensation between the amino groups on the resin and iodoacetic acid in a mixture of a solution of iodoacetic acid (0.6 mol/L, 0.3 mL) in NMP/DMF (1/1) and a solution of diisopropylcarbodiimide (DIC) in N,N-dimethylformamide (DMF) (10% v/v, 0.36 mL) to obtain Compound 2181-a-resin in which the N-terminus of the peptide on the resin was iodinated. By further allowing 2-(2-aminoethoxy)-N,N-dimethylethanamine (CAS: 85322-63-0) (0.45 mol/L solution in N-methylpyrrolidone, 0.3 mL) to react in the presence of DIPEA, iodine was substituted with an amino group to obtain Compound 2181-b-resin. Subsequent peptide chain elongation and cyclic peptide synthesis were performed according to the basic peptide synthesis method to give Compound 2181 ((3S,6S,9S,13S,16S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-23-[2-[2-(dimethylamino)ethoxy]ethyl]-9-isobutyl-N,N,3,4,10,14,17,29,32-nonamethyl-6,16-bis[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-31-(p-tolylmethyl)spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide) (1.7 mg, 2.5%). 
     LCMS (ESI) m/z=1485.2 (M+H)+ 
     Retention time: 0.77 min (analysis condition SQDFA05) 
     Synthesis of Compound 2182 ((3S,6S,9S,13S,16S,25S,31S,34S)-23-[2-(azetidin-3-yl)ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-25-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide) 
     Compound 2182 was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Peptide synthesis according to the basic peptide synthesis method described in the present Example was performed using Compound aa011-resin ((3S)-4-(dimethylamino)-3-[19H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxobutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp (0-Trt(2-Cl)resin)-NMe2) (100 mg, 0.456 mmol/g, 0.0456 mmol) as a raw material. Elongation with Fmoc-MeGly(cPent)-OH (aa079) and then with Fmoc-cLeu-OH, and deprotection of the Fmoc group were followed by condensation between the amino groups on the resin and iodoacetic acid in a mixture of a solution of iodoacetic acid (0.6 mol/L, 0.3 mL) in NMP/DMF (1/1) and a solution of diisopropylcarbodiimide (DIC) in N,N-dimethylformamide (DMF) (10% v/v, 0.36 mL) to obtain Compound 2182-a-resin in which the N-terminus of the peptide on the resin was iodinated. By further allowing 1-azetidine carboxylic acid, 3-(2-aminoethyl)-phenylmethylester (CAS: 1420898-03-8) (0.45 mol/L solution in N-methylpyrrolidone, 0.3 mL) to react in the presence of DIPEA, Compound 2182-b-resin was obtained. Subsequent peptide chain elongation and cyclic peptide synthesis were performed according to the basic peptide synthesis method to give Compound 2182-c (6 mg, 2.5%). Compound 2182-c (6 mg) was dissolved in acetic acid (1 mL), and 10 wt % palladium-activated carbon (5.0 mg) was added thereto. Upon purging the reaction vessel with hydrogen, this mixture was stirred at room temperature for one hour. With additional 10 wt % palladium-activated carbon (5.0 mg), the mixture was stirred under a hydrogen atmosphere at room temperature for another two hours. The reaction solution was filtered through celite, the solids were washed with ethanol, and then the filtrate was concentrated under reduced pressure to obtain a crude product. The crude product was purified by fractionation HPLC to obtain Compound 2182 ((3S,6S,9S,13S,16S,25S,31S,34S)-23-[2-(azetidin-3-yl)ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-25-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-9-isobutyl-N,N,3,4,10,14,17,29,32-nonamethyl-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide) (1.25 mg, 23%). 
     LCMS (ESI) m/z=1441.2 (M+H)+ 
     Retention time: 2.42 min (analysis condition SQDFA05long) 
     Synthesis of Compound 2183 ((3S,6S,9S,13S,16S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,29,32-nonamethyl-23-[2-[2-(methylamino)ethoxy]ethyl]-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide) 
     Compound 2183 was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Carbamic acid, N-[2-[2-(methylamino)ethoxy]ethyl]-,1,1-dimethylethylester (CAS: 1185772-28-4) (2.00 g, 9.16 mmol) was dissolved in a mixture of THF (3 mL) and water (2 mL), and cooled to 0° C. Aqueous sodium carbonate solution (2 mol/L, 4.58 mL, 1 equivalent) and allyl chloroformate (Alloc-Cl) (0.883 g, 0.8 equivalents) were added thereto, and then aqueous sodium carbonate solution (2 mol/L, 2.29 mL, 0.5 equivalents) was added, and the mixture was stirred at room temperature for 45 minutes. The reaction solution was diluted with water, and extracted twice with MTBE. The organic phases were combined, the mixture was washed with brine and dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain Compound 2183-a (1.79 g, 64.6%). 
     LCMS (ESI) m/z=303.18 (M+H)+(analysis condition SQDFA05) 
       1 H-NMR (DMSO-D 6 ) δ: 6.79-6.67 (1H, m), 6.00-5.83 (1H, m), 5.31-5.22 (1H, m), 5.20-5.13 (1H, m), 4.53-4.48 (1H, m), 3.49 (2H, t, J=5.6 Hz), 3.40-3.32 (4H, m), 3.05 (2H, q, J=5.8 Hz),2.91-2.82 (3H, m), 1.37 (9H, s). 
     To the above-obtained Compound 2183-a (0.9 g, 2.98 mmol) was added a hydrogen chloride, 1,4-dioxane solution (4 mol/L, 6.61 mL, 8.5 equivalents), and the mixture was allowed to react at room temperature for six hours. The reaction solution was concentrated to obtain Compound 2183-b (1.08 g). 
     LCMS (ESI) m/z=203.06 (M+H)+(analysis condition SQDFA05) 
       1 H-NMR (DMSO-D 6 ) δ: 7.89 (3H, bs), 5.92 (1H, ddd, J=16.2, 10.7, 5.2 Hz), 5.31-5.23 (1H, m), 5.21-5.16 (1H, m), 4.53-4.49 (2H, m), 3.62-3.51 (4H, m), 3.44-3.37 (2H, m), 3.00-2.92 (2H, m), 2.92-2.84 (3H, m). 
     Compound 2182-a-resin was allowed to react with carbamic acid, N-[2-(2-aminoethoxy)ethyl]-N-methyl-,2-propan-1-ylester hydrochloride (Compound 2183-b) (0.45 mol/L solution in N-methyl pyrrolidone, 0.3 mL) in the presence of DIPEA to obtain Compound2183-c-resin. Subsequent peptide chain elongation and cyclic peptide synthesis were carried out according to the basic peptide synthesis method to obtain Compound 2183-d (6.59 mg). 
     Compound 2183-d (6.59 mg) was dissolved in tetrahydrofuran (1 mL) under a nitrogen atmosphere, and a solution of zinc chloride in tetrahydrofuran (0.5 M, 84 μL), tetramethyldisiloxane (30 μL), and tetrakistriphenylphosphine palladium (2.4 mg) were added. The reaction vessel was shaken at room temperature for three hours. The reaction solution was concentrated under reduced pressure to obtain a crude product. The crude product was purified by fractionation HPLC to obtain Compound 2183 ((3S,6S,9S,13S,16S,25S,31S,34S)-25-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-31-(cyclohexylmethyl)-16-cyclopentyl-9-isobutyl-N,N,3,4,10,14,17,29,32-nonamethyl-23-[2-[2-(methylamino)ethoxy]ethyl]-6-[(1S)-1-methylpropyl]-2,5,8,11,15,18,21,24,27,30,33-undecaoxo-spiro[1,4,7,10,14,17,20,23,26,29,32-undecazabicyclo[32.2.0]hexatriacontane-19,1′-cyclopentane]-13-carboxamide) (1.18 mg, 19%). 
     LCMS (ESI) m/z=1475.2 (M+H)+ 
     Retention time: 2.55 min (analysis condition SQDFA05long) 
     Synthesis of Compound 2184 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-9-(2-piperazin-1-ylethyl)-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) 
     Compound 2184 was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Carbamic acid, N-[2-(1-piperazinyl)ethyl]-,1,1-dimethylethylester (CAS: 140447-78-5) (4.84 g, 21.11 mmol) was dissolved in a mixture of THF (3 mL) and water (2 mL), and cooled to 0° C. Aqueous sodium carbonate solution (2 mol/L, 10.55 mL, 1 equivalent) and allyl chloroformate (Alloc-Cl) (2.035 g, 0.8 equivalents) were added thereto, and then aqueous sodium carbonate solution (2 mol/L, 5.28 mL, 0.5 equivalents) was added, and the mixture was stirred at room temperature for three hours. The reaction solution was diluted with water, and extracted twice with MTBE. The organic phases were combined, the mixture was washed with brine and dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain Compound 2184-a (4.46 g, 84%). 
     LCMS (ESI) m/z=314.19 (M+H)+ 
     Retention time: 0.85 min (analysis condition SQDAA05) 
     To the above-obtained Compound 2184-a (1 g, 3.19 mmol) was added a hydrogen chloride, 1,4-dioxane solution (4 mol/L, 6.78 mL, 8.5 equivalents), and the mixture was allowed to react at room temperature overnight. The reaction solution was concentrated to obtain Compound 2184-b (884.1 mg). 
     LCMS (ESI) m/z=214.10 (M+H)+(analysis condition SQDAA05) 
       1 H-NMR (DMSO-D 6 ) δ: 8.40 (3H, bs), 5.94 (1H, ddd, J=17.2, 10.5, 5.3 Hz), 5.31 (1H, dq, J=17.2, 1.6 Hz), 5.22 (1H, dq, J=10.5, 1.4 Hz), 4.60-4.55 (2H, m), 4.20-3.00 (12H, m). 
     Compound 2035-a-resin (100 mg, 0.0462 mmol) was allowed to react with Compound 2184-b (0.45 mol/L solution in N-methyl pyrrolidone, 0.3 mL) in the presence of DIPEA to obtain Compound 2184-c-resin. Subsequent peptide chain elongation and cyclic peptide synthesis were carried out according to the basic peptide synthesis method to obtain Compound 2184-d as a crude product. 
     To Compound 2184-d in THF (0.25 mL), phenylsilane (3.5 mg, 0.32 mmol) and tetrakistriphenylphosphine palladium (14.5 mg, 0.013 mmol) were sequentially added, and the mixture was allowed to react at room temperature for 8 hours and 30 minutes. The obtained reaction solution was purified by reverse phase HPLC to obtain Compound 2184 ((11S,17S,26S,29S,33S,36S)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-9-(2-piperazin-1-ylethyl)-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) (2.6 mg, 4.2%). 
     LCMS (ESI) m/z=1511.7 (M−H)− 
     Retention time: 0.80 min (analysis condition SQDAA05) 
     Synthesis of Compound 2185 ((11S,17S,26S,29S,33S,36S)-9-[2-(2-aminoethoxy)ethyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) 
     Compound 2185 was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Carbamic acid, N-[2-(2-aminoethoxy)ethyl]-,1,1-dimethylethylester (CAS: 127828-22-2) (2 g, 9.79 mmol) was dissolved in a mixture of THF (3 mL) and water (2 mL), and cooled to 0° C. Aqueous sodium carbonate solution (2 mol/L, 4.9 mL, 1 equivalent) and allyl chloroformate (Alloc-Cl) (0.828 mL, 7.83 mmol, 0.8 equivalents) were added thereto at 0° C., and then aqueous sodium carbonate solution (2 mol/L, 2.448 mL, 0.5 equivalents) was added, and the mixture was stirred at room temperature. 2.5 hours later, the reaction solution was diluted with water, and extracted twice with MTBE. The organic phases were combined, the mixture was washed with brine and then dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain Compound 2185-a (1.5 g, 66%). 
     LCMS (ESI) m/z=289.13 (M+H)+ 
     Retention time: 0.62 min (analysis condition SQDFA05) 
     To the above-obtained Compound 2185-a (1.5 g, 5.2 mmol) was added a hydrogen chloride, 1,4-dioxane solution (4 mol/L, 11.05 mL, 8.5 equivalents), and the mixture was stirred at room temperature for six hours. The solvent was evaporated from the reaction solution under reduced pressure to obtain Compound 2185-b (1.35 g). 
     LCMS (ESI) m/z=189.03 (M+H)+(analysis condition SQDFA05) 
       1 H-NMR (DMSO-D 6 ) δ: 7.96 (3H, bs), 7.32-7.20 (1H, m), 5.91 (1H, ddd, J=17.2, 10.6, 5.3 Hz), 5.33-5.24 (1H, m), 5.20-5.15 (1H, m), 4.53-4.44 (2H, m), 3.65-3.52 (2H, m), 3.63 (2H, t, J=5.7 Hz), 3.19 (2H, q, J=5.7 Hz), 3.03-2.90 (2H, m). 
     Compound 2035-a-resin (100 mg, 0.0462 mmol) was allowed to react with Compound 2185-b (0.45 mol/L solution in N-methyl pyrrolidone, 0.3 mL) in the presence of DIPEA to obtain Compound 2185-c-resin. Subsequent peptide chain elongation and cyclic peptide synthesis were carried out according to the basic peptide synthesis method to obtain Compound 2185-d (6.66 mg). 
     Compound 2185-d (6.66 mg) was dissolved in tetrahydrofuran (1 mL) under a nitrogen atmosphere, and a solution of zinc chloride in tetrahydrofuran (0.5 mol/L, 84 μL), tetramethyldisiloxane (30 μL), and tetrakistriphenylphosphine palladium (2.4 mg) were added thereto, and the mixture was stirred at room temperature for three hours. The reaction solution was concentrated under reduced pressure to obtain a crude product. The crude product was purified by fractionation HPLC to obtain Compound 2185 ((11S,17S,26S,29S,33S,36S)-9-[2-(2-aminoethoxy)ethyl]-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) (1.51 mg, 24%). 
     LCMS (ESI) m/z=1489.2 (M+H)+ 
     Retention time: 2.73 min (analysis condition SQDFA05long) 
     Synthesis of Compound 2186 ((11S,17S,26S,29S,33S,36S)-9-(4-aminobutyl)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) 
     Compound 2186 was synthesized according to the following scheme. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     The target Compound 2186-a (1.282 g, 0.893 mmol, 52%) was obtained using Compound aa006-resin ((3S)-3-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-4-oxo-4-piperidin-1-ylbutanoic acid-2-chlorotrityl resin, Fmoc-MeAsp(0-Trt(2-Cl)resin)-pip) (0.411 mmol/g, 4.2 g, 1.726 mmol) as a starting material, and using Fmoc-MeChg-OH, Fmoc-cLeu-OH, Fmoc-AllylGly-OH, Fmoc-Hph(4-CF3-3-Cl)—OH, Fmoc-MeGly-OH, Fmoc-MeCha-OH, Fmoc-MeGly-OH, Fmoc-MeGly-OH, Fmoc-Ile-OH, and Fmoc-MeLeu-OH by performing the above-described peptide elongation reaction by the Fmoc method, cleavage of the elongated peptide from the resin, cyclization of the cleaved peptide (using (1-cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino-mopholino-carbeniumhexafluorophosphate (COMU) as the cyclizing agent), and purification of the cyclic peptide (reverse phase medium pressure column chromatography, C18, methanol/10 mM aqueous ammonium acetate solution)). 
     LCMS (ESI) m/z=1440.13 (M−H)− 
     Retention time: 0.88 min (analysis condition SQDAA50) 
     Compound 2186-a (50.0 mg, 0.35 mmol) was dissolved in dichloroethane (0.69 mL), Stewart-Grubbs catalyst (29.7 mg, 1.5 equivalents) and N-allylphthalimide (51.9 mg, 8 equivalents) were added thereto, and the mixture was stirred at room temperature for two hours. Stewart-Grubbs catalyst (30 mg, 1.5 equivalents) and N-allylphthalimide (104 mg, 16 equivalents) were further added and the mixture was stirred for three hours, then the reaction solution was concentrated under reduced pressure, and the obtained residue was purified by reverse phase medium pressure column chromatography (acetonitrile with 0.1% formic acid/water with 0.1% formic acid) to obtain Compound 2186-b (2.0 mg, 3.6%). 
     Compound 2186-b (2.0 mg, 1.249 μmol) was dissolved in ethanol (1.0 mL), and platinum (IV) oxide (3.9 mg, 14 equivalents) was added thereto. The reaction vessel was purged with hydrogen, and the mixture was stirred at room temperature for 30 min. The reaction solution was filtered through celite, solids were washed with ethanol, and then the filtrate was concentrated under reduced pressure to obtain Compound 2186-c. The next reaction was carried out without further purification. The obtained Compound 2186-c was dissolved in ethanol (1.0 mL), hydrazine-hydrate (0.03 mL) was added, and the mixture was stirred at 80° C. for 24 hours. The solvent was evaporated from the reaction solution under reduced pressure to obtain Compound 2186 as a crude product. The crude product was mixed with the crude product of Compound 2186 obtained using Compound 2186-a (0.7 mg) by performing olefin metathesis reaction, reduction by platinum oxide, and further treatment with hydrazine-hydrate similarly, and reverse phase HPLC purification was performed to obtain Compound 2186 ((11S,17S,26S,29S,33S,36S)-9-(4-aminobutyl)-11-[2-[3-chloro-4-(trifluoromethyl)phenyl]ethyl]-36-cyclohexyl-17-(cyclohexylmethyl)-29-isobutyl-15,18,21,24,30,34,37-heptamethyl-26-[(1S)-1-methylpropyl]-33-(piperidine-1-carbonyl)-6,9,12,15,18,21,24,27,30,34,37-undecazaspiro[4.33]octatriacontane-7,10,13,16,19,22,25,28,31,35,38-undecone) (0.48 mg, 1%). 
     LCMS (ESI) m/z=1473.3 (M+H)+ 
     Retention time: 2.77 min (analysis condition SQDFA05long) 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 22 
               
               
                   
               
               
                 Compound No. 
                 Analytical condition 
                 Retention time (min) 
                 MS Found(m/z) 
                 MS polarity 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 1 
                 SSC-FA-03 
                 2.155 
                 1480.1 
                 (M − H)− 
               
               
                 2 
                 SSC-TFA-07 
                 1.575 
                 1318.8 
                 (M + H)+ 
               
               
                 3 
                 SSC-FA-03 
                 1.948 
                 1520.8 
                 (M − H)− 
               
               
                 4 
                 SSC-FA-03 
                 1.788 
                 1383.9 
                 (M − H)− 
               
               
                 5 
                 SSC-A-AF-01 
                 7.456 
                 1436.0 
                 (M + H)+ 
               
               
                 6 
                 SSC-AF-00 
                 2.247 
                 1584.9 
                 (M − H)− 
               
               
                 7 
                 SSC-FA-03 
                 1.823 
                 1414.0 
                 (M − H)− 
               
               
                 8 
                 SSC-AF-00 
                 2.225 
                 1341.0 
                 (M − H)− 
               
               
                 9 
                 SSC-FA-03 
                 1.688 
                 1414.0 
                 (M − H)− 
               
               
                 10 
                 SSC-FA-03 
                 2.165 
                 1572.8 
                 (M − H)− 
               
               
                 11 
                 SSC-A-FA-01 
                 5.059 
                 1425.7 
                 (M − H)− 
               
               
                 12 
                 SSC-TFA-07 
                 1.416 
                 1401.7 
                 (M + H)+ 
               
               
                 13 
                 SSC-AF-00 
                 2.160 
                 1470.0 
                 (M − H)− 
               
               
                 14 
                 SSC-TFA-07 
                 1.415 
                 1288.7 
                 (M + H)+ 
               
               
                 15 
                 SSC-TFA-07 
                 1.408 
                 1441.7 
                 (M + H)+ 
               
               
                 15 
                 SSC-FA-03 
                 1.708 
                 1404.0 
                 (M − H)− 
               
               
                 17 
                 SSC-FA-03 
                 1.827 
                 1427.8 
                 (M − H)− 
               
               
                 18 
                 SSC-TFA-07 
                 1.337 
                 1238.7 
                 (M + H)+ 
               
               
                 19 
                 SSC-AF-00 
                 2.084 
                 1224.6 
                 (M − H)− 
               
               
                 20 
                 SSC-FA-03 
                 1.748 
                 1429.9 
                 (M − H)− 
               
               
                 21 
                 SSC-TFA-07 
                 1.296 
                 1379.6 
                 (M + H)+ 
               
               
                 22 
                 SSC-TFA-07 
                 1.577 
                 1332.7 
                 (M + H)+ 
               
               
                 23 
                 SSC-FA-03 
                 2.037 
                 1440.0 
                 (M − H)− 
               
               
                 24 
                 SSC-AF-00 
                 2.112 
                 1373.9 
                 (M − H)− 
               
               
                 25 
                 SSC-AA-20 
                 2.107 
                 1330.8 
                 (M − H)− 
               
               
                 26 
                 SSC-A-FA-01 
                 6.444 
                 1574.7 
                 (M + H)+ 
               
               
                 27 
                 SSC-AF-00 
                 2.209 
                 1481.9 
                 (M − H)− 
               
               
                 28 
                 SSC-TFA-07 
                 1.295 
                 1210.8 
                 (M + H)+ 
               
               
                 29 
                 SSC-AA-20 
                 2.103 
                 1389.7 
                 (M − H)− 
               
               
                 30 
                 SSC-TFA-07 
                 1.599 
                 1441.8 
                 (M + H)+ 
               
               
                 31 
                 SSC-TFA-07 
                 1.480 
                 1258.9 
                 (M + H)+ 
               
               
                 32 
                 SSC-AF-00 
                 2.060 
                 1367.9 
                 (M − H)− 
               
               
                 33 
                 SSC-A-FA-02 
                 6.625 
                 1412.7 
                 (M + H)+ 
               
               
                 34 
                 SSC-A-FA-02 
                 6.601 
                 1454.6 
                 (M − H)− 
               
               
                 35 
                 SSC-AF-00 
                 2.153 
                 1411.9 
                 (M − H)− 
               
               
                 36 
                 SSC-FA-03 
                 1.727 
                 1504.8 
                 (M − H)− 
               
               
                 37 
                 SSC-TFA-07 
                 1.615 
                 1453.8 
                 (M + H)+ 
               
               
                 38 
                 SSC-TFA-07 
                 1.627 
                 1356.7 
                 (M + H)+ 
               
               
                 39 
                 SSC-A-FA-01 
                 6.352 
                 1434.6 
                 (M + H)+ 
               
               
                 40 
                 SSC-AF-00 
                 2.156 
                 1441.8 
                 (M − H)− 
               
               
                 41 
                 SSC-A-AF-01 
                 7.864 
                 1536.8 
                 (M − H)− 
               
               
                 42 
                 SSC-FA-03 
                 1.881 
                 1340.5 
                 (M − H)− 
               
               
                 43 
                 SSC-FA-03 
                 2.056 
                 1494.0 
                 (M − H)− 
               
               
                 44 
                 SSC-FA-03 
                 1.749 
                 1418.0 
                 (M − H)− 
               
               
                 45 
                 SSC-FA-03 
                 1.953 
                 1453.9 
                 (M − H)− 
               
               
                 46 
                 SSC-TFA-07 
                 1.403 
                 1372.0 
                 (M + H)+ 
               
               
                 47 
                 SSC-AF-00 
                 2.053 
                 1433.9 
                 (M − H)− 
               
               
                 48 
                 SSC-A-AF-02 
                 8.379 
                 1475.8 
                 (M − H)− 
               
               
                 49 
                 SSC-AF-00 
                 2.168 
                 1339.0 
                 (M − H)− 
               
               
                 50 
                 SSC-TFA-07 
                 1.404 
                 1405.7 
                 (M + H)+ 
               
               
                 51 
                 SSC-TFA-07 
                 1.475 
                 1322.7 
                 (M + H)+ 
               
               
                 52 
                 SSC-AF-00 
                 2.165 
                 1490.0 
                 (M − H)− 
               
               
                 53 
                 SSC-TFA-07 
                 1.335 
                 1444.9 
                 (M + H)+ 
               
               
                 54 
                 SSC-A-FA-01 
                 5.477 
                 1503.7 
                 (M − H)− 
               
               
                 55 
                 SSC-A-AF-01 
                 7.507 
                 1448.1 
                 (M − H)− 
               
               
                 56 
                 SSC-AF-00 
                 2.199 
                 1411.9 
                 (M − H)− 
               
               
                 57 
                 SSC-TFA-07 
                 1.532 
                 1320.7 
                 (M + H)+ 
               
               
                 58 
                 SSC-AF-00 
                 2.221 
                 1452.0 
                 (M − H)− 
               
               
                 59 
                 SSC-TFA-07 
                 1.545 
                 1316.7 
                 (M + H)+ 
               
               
                 60 
                 SSC-AF-00 
                 2.204 
                 1426.0 
                 (M − H)− 
               
               
                 61 
                 SSC-TFA-07 
                 1.528 
                 1292.7 
                 (M + H)+ 
               
               
                 62 
                 SSC-A-AF-02 
                 7.791 
                 1414.6 
                 (M + H)+ 
               
               
                 63 
                 SSC-AF-00 
                 2.223 
                 1504.8 
                 (M − H)− 
               
               
                 64 
                 SSC-AF-00 
                 2.340 
                 1383.0 
                 (M − H)− 
               
               
                 65 
                 SSC-TFA-07 
                 1.439 
                 1366.5 
                 (M + H)+ 
               
               
                 66 
                 SSC-A-FA-02 
                 6.275 
                 1438.7 
                 (M + H)+ 
               
               
                 67 
                 SSC-FA-03 
                 1.788 
                 1381.8 
                 (M − H)− 
               
               
                 68 
                 SSC-AF-00 
                 2.223 
                 1437.8 
                 (M − H)− 
               
               
                 69 
                 SSC-AF-00 
                 2.165 
                 1421.9 
                 (M − H)− 
               
               
                 70 
                 SSC-TFA-07 
                 1.588 
                 1445.7 
                 (M + H)+ 
               
               
                 71 
                 SSC-AF-00 
                 2.083 
                 1332.4 
                 (M − H)− 
               
               
                 72 
                 SSC-FA-03 
                 1.877 
                 1363.7 
                 (M − H)− 
               
               
                 73 
                 SSC-FA-03 
                 1.884 
                 1485.7 
                 (M − H)− 
               
               
                 74 
                 SSC-A-FA-02 
                 6.389 
                 1376.8 
                 (M + H)+ 
               
               
                 75 
                 SSC-TFA-07 
                 1.407 
                 1262.6 
                 (M + H)+ 
               
               
                 76 
                 SSC-TFA-07 
                 1.524 
                 1316.7 
                 (M + H)+ 
               
               
                 77 
                 SSC-AF-00 
                 2.164 
                 1284.7 
                 (M − H)− 
               
               
                 78 
                 SSC-FA-03 
                 1.844 
                 1435.9 
                 (M − H)− 
               
               
                 79 
                 SSC-FA-03 
                 1.909 
                 1314.8 
                 (M − H)− 
               
               
                 80 
                 SSC-AF-00 
                 2.153 
                 1427.9 
                 (M − H)− 
               
               
                 81 
                 SSC-TFA-07 
                 1.545 
                 1318.7 
                 (M + H)+ 
               
               
                 82 
                 SSC-FA-03 
                 1.899 
                 1328.4 
                 (M + H)+ 
               
               
                 83 
                 SSC-TFA-07 
                 1.453 
                 1320.8 
                 (M + H)+ 
               
               
                 84 
                 SSC-AF-00 
                 2.244 
                 1451.8 
                 (M − H)− 
               
               
                 85 
                 SSC-A-FA-02 
                 6.600 
                 1444.6 
                 (M + H)+ 
               
               
                 86 
                 SSC-AF-00 
                 2.189 
                 1514.1 
                 (M − H)− 
               
               
                 87 
                 SSC-AF-00 
                 2.276 
                 1480.0 
                 (M − H)− 
               
               
                 88 
                 SSC-TFA-07 
                 1.463 
                 1290.7 
                 (M + H)+ 
               
               
                 89 
                 SSC-AF-00 
                 2.180 
                 1581.9 
                 (M − H)− 
               
               
                 90 
                 SSC-AF-00 
                 2.292 
                 1517.8 
                 (M + H)+ 
               
               
                 91 
                 SSC-FA-03 
                 1.785 
                 1413.9 
                 (M − H)− 
               
               
                 92 
                 SSC-AF-00 
                 2.203 
                 1490.0 
                 (M − H)− 
               
               
                 93 
                 SSC-AF-00 
                 2.033 
                 1234.7 
                 (M − H)− 
               
               
                 94 
                 SSC-FA-03 
                 1.928 
                 1475.8 
                 (M − H)− 
               
               
                 95 
                 SSC-FA-03 
                 2.059 
                 1493.8 
                 (M − H)− 
               
               
                 96 
                 SSC-TFA-07 
                 1.424 
                 1389.8 
                 (M + H)+ 
               
               
                 97 
                 SSC-FA-03 
                 1.833 
                 1480.8 
                 (M − H)− 
               
               
                 98 
                 SSC-FA-03 
                 1.808 
                 1272.9 
                 (M − H)− 
               
               
                 99 
                 SSC-A-FA-02 
                 6.297 
                 1434.7 
                 (M − H)− 
               
               
                 100 
                 SSC-TFA-07 
                 1.465 
                 1411.6 
                 (M + H)+ 
               
               
                 101 
                 SSC-TFA-07 
                 1.407 
                 1274.6 
                 (M + H)+ 
               
               
                 102 
                 SSC-AF-00 
                 2.140 
                 1388.0 
                 (M − H)− 
               
               
                 103 
                 SSC-FA-03 
                 1.939 
                 1441.7 
                 (M − H)− 
               
               
                 104 
                 SSC-A-FA-01 
                 5.293 
                 1532.7 
                 (M − H)− 
               
               
                 105 
                 SSC-A-AF-01 
                 8.051 
                 1590.9 
                 (M + H)+ 
               
               
                 106 
                 SSC-TFA-07 
                 1.577 
                 1427.7 
                 (M + H)+ 
               
               
                 107 
                 SSC-A-FA-02 
                 6.531 
                 1366.6 
                 (M + H)+ 
               
               
                 108 
                 SSC-TFA-07 
                 1.476 
                 1367.7 
                 (M + H)+ 
               
               
                 109 
                 SSC-FA-03 
                 1.756 
                 1232.5 
                 (M − H)− 
               
               
                 110 
                 SSC-FA-03 
                 1.919 
                 1458.5 
                 (M − H)− 
               
               
                 111 
                 SSC-FA-03 
                 2.101 
                 1587.8 
                 (M − H)− 
               
               
                 112 
                 SSC-TFA-07 
                 1.459 
                 1345.7 
                 (M + H)+ 
               
               
                 113 
                 SSC-TFA-07 
                 1.616 
                 1356.7 
                 (M + H)+ 
               
               
                 114 
                 SSC-AF-00 
                 2.140 
                 1274.7 
                 (M − H)− 
               
               
                 115 
                 SSC-FA-03 
                 1.868 
                 1383.7 
                 (M − H)− 
               
               
                 116 
                 SSC-TFA-07 
                 1.589 
                 1318.7 
                 (M + H)+ 
               
               
                 117 
                 SSC-FA-03 
                 1.853 
                 1320.9 
                 (M − H)− 
               
               
                 118 
                 SSC-FA-03 
                 2.035 
                 1457.6 
                 (M − H)− 
               
               
                 119 
                 SSC-TFA-07 
                 1.549 
                 1310.8 
                 (M + H)+ 
               
               
                 120 
                 SSC-FA-03 
                 1.892 
                 1479.7 
                 (M − H)− 
               
               
                 121 
                 SSC-AF-00 
                 2.120 
                 1316.6 
                 (M − H)− 
               
               
                 122 
                 SSC-TFA-07 
                 1.547 
                 1316.7 
                 (M + H)+ 
               
               
                 123 
                 SSC-TFA-07 
                 1.645 
                 1332.7 
                 (M + H)+ 
               
               
                 124 
                 SSC-TFA-07 
                 1.589 
                 1364.6 
                 (M + H)+ 
               
               
                 125 
                 SSC-AF-00 
                 2.192 
                 1513.9 
                 (M − H)− 
               
               
                 126 
                 SSC-FA-03 
                 1.788 
                 1399.9 
                 (M − H)− 
               
               
                 127 
                 SSC-AF-00 
                 2.141 
                 1409.8 
                 (M − H)− 
               
               
                 128 
                 SSC-A-FA-01 
                 5.245 
                 1409.8 
                 (M − H)− 
               
               
                 129 
                 SSC-A-FA-01 
                 5.524 
                 1483.0 
                 (M − H)− 
               
               
                 130 
                 SSC-A-AF-01 
                 7.763 
                 1496.7 
                 (M + H)+ 
               
               
                 131 
                 SSC-TFA-07 
                 1.492 
                 1387.7 
                 (M + H)+ 
               
               
                 132 
                 SSC-A-FA-02 
                 6.548 
                 1464.6 
                 (M + H)+ 
               
               
                 133 
                 SSC-AF-00 
                 2.127 
                 1274.7 
                 (M + H)+ 
               
               
                 134 
                 SSC-FA-03 
                 1.717 
                 1367.6 
                 (M − H)− 
               
               
                 135 
                 SSC-AF-00 
                 2.163 
                 1383.9 
                 (M − H)− 
               
               
                 136 
                 SSC-TFA-07 
                 1.515 
                 1425.6 
                 (M + H)+ 
               
               
                 137 
                 SSC-FA-03 
                 2.113 
                 1454.0 
                 (M − H)− 
               
               
                 138 
                 SSC-A-AF-02 
                 8.124 
                 1454.6 
                 (M + H)+ 
               
               
                 139 
                 SSC-TFA-07 
                 1.481 
                 1397.8 
                 (M + H)+ 
               
               
                 140 
                 SSC-AF-00 
                 2.113 
                 1441.8 
                 (M − H)− 
               
               
                 141 
                 SSC-FA-03 
                 1.843 
                 1441.8 
                 (M − H)− 
               
               
                 142 
                 SSC-TFA-07 
                 1.533 
                 1314.8 
                 (M + H)+ 
               
               
                 143 
                 SSC-FA-03 
                 2.095 
                 1587.9 
                 (M − H)− 
               
               
                 144 
                 SSC-A-AF-01 
                 7.877 
                 1437.8 
                 (M − H)− 
               
               
                 145 
                 SSC-FA-03 
                 1.904 
                 1475.7 
                 (M − H)− 
               
               
                 146 
                 SSC-FA-03 
                 1.795 
                 1310.4 
                 (M − H)− 
               
               
                 147 
                 SSC-AF-00 
                 2.289 
                 1530.0 
                 (M + H)+ 
               
               
                 148 
                 SSC-FA-03 
                 1.949 
                 1427.9 
                 (M − H)− 
               
               
                 149 
                 SSC-TFA-07 
                 1.455 
                 1278.7 
                 (M + H)+ 
               
               
                 150 
                 SSC-FA-03 
                 1.873 
                 1412.0 
                 (M − H)− 
               
               
                 151 
                 SSC-FA-03 
                 1.889 
                 1306.7 
                 (M − H)− 
               
               
                 152 
                 SSC-AF-00 
                 2.093 
                 1403.8 
                 (M − H)− 
               
               
                 153 
                 SSC-TFA-07 
                 1.349 
                 1226.7 
                 (M + H)+ 
               
               
                 154 
                 SSC-A-FA-01 
                 4.451 
                 1470.6 
                 (M + H)+ 
               
               
                 155 
                 SSC-A-FA-01 
                 5.567 
                 1423.8 
                 (M − H)− 
               
               
                 156 
                 SSC-AF-00 
                 2.148 
                 1373.9 
                 (M − H)− 
               
               
                 157 
                 SSC-AF-00 
                 2.175 
                 1424.0 
                 (M − H)− 
               
               
                 158 
                 SSC-TFA-07 
                 1.493 
                 1360.6 
                 (M + H)+ 
               
               
                 159 
                 SSC-FA-03 
                 1.847 
                 1401.9 
                 (M − H)− 
               
               
                 160 
                 SSC-AF-00 
                 2.233 
                 1429.5 
                 (M + H)+ 
               
               
                 161 
                 SSC-AF-00 
                 2.171 
                 1555.7 
                 (M − H)− 
               
               
                 162 
                 SSC-AF-00 
                 2.091 
                 1463.9 
                 (M − H)− 
               
               
                 163 
                 SSC-A-FA-01 
                 5.444 
                 1455.8 
                 (M − H)− 
               
               
                 164 
                 SSC-AF-00 
                 2.193 
                 1424.0 
                 (M − H)− 
               
               
                 165 
                 SSC-TFA-07 
                 1.468 
                 1320.8 
                 (M + H)+ 
               
               
                 166 
                 SSC-AF-00 
                 2.211 
                 1462.0 
                 (M − H)− 
               
               
                 167 
                 SSC-TFA-07 
                 1.425 
                 1319.8 
                 (M + H)+ 
               
               
                 168 
                 SSC-FA-03 
                 2.059 
                 1537.6 
                 (M − H)− 
               
               
                 169 
                 SSC-AF-00 
                 2.184 
                 1503.9 
                 (M − H)− 
               
               
                 170 
                 SSC-AA-20 
                 2.055 
                 1244.6 
                 (M − H)− 
               
               
                 171 
                 SSC-FA-03 
                 1.953 
                 1457.9 
                 (M − H)− 
               
               
                 172 
                 SSC-FA-03 
                 1.933 
                 1437.9 
                 (M − H)− 
               
               
                 173 
                 SSC-AF-00 
                 2.108 
                 1555.9 
                 (M − H)− 
               
               
                 174 
                 SSC-FA-03 
                 1.755 
                 1475.9 
                 (M − H)− 
               
               
                 175 
                 SSC-AF-00 
                 2.077 
                 1389.6 
                 (M + H)+ 
               
               
                 176 
                 SSC-AF-00 
                 2.109 
                 1455.8 
                 (M − H)− 
               
               
                 177 
                 SSC-AF-00 
                 2.179 
                 1466.8 
                 (M − H)− 
               
               
                 178 
                 SSC-TFA-07 
                 1.497 
                 1304.8 
                 (M + H)+ 
               
               
                 179 
                 SSC-FA-03 
                 2.097 
                 1509.9 
                 (M − H)− 
               
               
                 180 
                 SSC-TFA-07 
                 1.488 
                 1498.8 
                 (M + H)+ 
               
               
                 181 
                 SSC-TFA-07 
                 1.453 
                 1314.7 
                 (M + H)+ 
               
               
                 182 
                 SSC-AF-00 
                 2.161 
                 1423.8 
                 (M − H)− 
               
               
                 183 
                 SSC-TFA-07 
                 1.489 
                 1302.7 
                 (M + H)+ 
               
               
                 184 
                 SSC-TFA-07 
                 1.269 
                 1361.8 
                 (M + H)+ 
               
               
                 185 
                 SSC-TFA-07 
                 1.525 
                 1316.7 
                 (M + H)+ 
               
               
                 186 
                 SSC-FA-03 
                 1.887 
                 1328.4 
                 (M + H)+ 
               
               
                 187 
                 SSC-FA-03 
                 1.911 
                 1385.9 
                 (M − H)− 
               
               
                 188 
                 SSC-FA-03 
                 1.817 
                 1497.8 
                 (M − H)− 
               
               
                 189 
                 SSC-TFA-07 
                 1.544 
                 1354.7 
                 (M + H)+ 
               
               
                 190 
                 SSC-A-AF-01 
                 7.563 
                 1466.6 
                 (M − H)− 
               
               
                 191 
                 SSC-AF-00 
                 2.135 
                 1386.0 
                 (M − H)− 
               
               
                 192 
                 SSC-FA-03 
                 1.991 
                 1435.9 
                 (M − H)− 
               
               
                 193 
                 SSC-A-FA-01 
                 5.300 
                 1367.9 
                 (M − H)− 
               
               
                 194 
                 SSC-FA-03 
                 1.837 
                 1312.5 
                 (M + H)+ 
               
               
                 195 
                 SSC-FA-03 
                 1.811 
                 1383.9 
                 (M − H)− 
               
               
                 196 
                 SSC-TFA-07 
                 1.380 
                 1262.7 
                 (M + H)+ 
               
               
                 197 
                 SSC-TFA-07 
                 1.469 
                 1399.8 
                 (M + H)+ 
               
               
                 198 
                 SSC-A-FA-02 
                 6.440 
                 1368.7 
                 (M + H)+ 
               
               
                 199 
                 SSC-TFA-07 
                 1.440 
                 1419.9 
                 (M + H)+ 
               
               
                 200 
                 SSC-FA-03 
                 2.148 
                 1467.6 
                 (M − H)− 
               
               
                 201 
                 SSC-AF-00 
                 2.105 
                 1410.0 
                 (M − H)− 
               
               
                 202 
                 SSC-AF-00 
                 2.165 
                 1367.7 
                 (M − H)− 
               
               
                 203 
                 SSC-A-FA-02 
                 6.648 
                 1456.6 
                 (M + H)+ 
               
               
                 204 
                 SSC-TFA-07 
                 1.532 
                 1316.7 
                 (M + H)+ 
               
               
                 205 
                 SSC-FA-03 
                 2.016 
                 1413.9 
                 (M − H)− 
               
               
                 206 
                 SSC-FA-03 
                 1.836 
                 1298.5 
                 (M − H)− 
               
               
                 207 
                 SSC-TFA-07 
                 1.403 
                 1330.6 
                 (M + H)+ 
               
               
                 208 
                 SSC-AF-00 
                 2.156 
                 1469.7 
                 (M − H)− 
               
               
                 209 
                 SSC-A-AF-01 
                 7.703 
                 1489.9 
                 (M + H)+ 
               
               
                 210 
                 SSC-TFA-07 
                 1.543 
                 1304.7 
                 (M + H)+ 
               
               
                 211 
                 SSC-TFA-07 
                 1.445 
                 1286.7 
                 (M + H)+ 
               
               
                 212 
                 SSC-TFA-07 
                 1.432 
                 1276.7 
                 (M + H)+ 
               
               
                 213 
                 SSC-TFA-07 
                 1.604 
                 1318.7 
                 (M + H)+ 
               
               
                 214 
                 SSC-TFA-07 
                 1.453 
                 1322.9 
                 (M + H)+ 
               
               
                 215 
                 SSC-A-FA-01 
                 5.729 
                 1410.0 
                 (M − H)− 
               
               
                 216 
                 SSC-FA-03 
                 1.985 
                 1505.8 
                 (M − H)− 
               
               
                 217 
                 SSC-TFA-07 
                 1.632 
                 1334.7 
                 (M + H)+ 
               
               
                 218 
                 SSC-FA-03 
                 1.879 
                 1494.9 
                 (M − H)− 
               
               
                 219 
                 SSC-AF-00 
                 2.105 
                 1232.8 
                 (M + H)+ 
               
               
                 220 
                 SSC-TFA-07 
                 1.487 
                 1387.7 
                 (M + H)+ 
               
               
                 221 
                 SSC-TFA-07 
                 1.505 
                 1399.7 
                 (M + H)+ 
               
               
                 222 
                 SSC-A-FA-01 
                 6.188 
                 1548.7 
                 (M + H)+ 
               
               
                 223 
                 SSC-TFA-07 
                 1.479 
                 1292.7 
                 (M + H)+ 
               
               
                 224 
                 SSC-AA-20 
                 2.103 
                 1389.7 
                 (M − H)− 
               
               
                 225 
                 SSC-AF-00 
                 2.200 
                 1438.0 
                 (M − H)− 
               
               
                 226 
                 SSC-FA-03 
                 2.073 
                 1467.8 
                 (M − H)− 
               
               
                 227 
                 SSC-TFA-07 
                 1.397 
                 1282.7 
                 (M + H)+ 
               
               
                 228 
                 SSC-AF-00 
                 2.136 
                 1427.8 
                 (M − H)− 
               
               
                 229 
                 SSC-TFA-07 
                 1.424 
                 1413.7 
                 (M + H)+ 
               
               
                 230 
                 SSC-TFA-07 
                 1.499 
                 1302.6 
                 (M + H)+ 
               
               
                 231 
                 SSC-TFA-07 
                 1.524 
                 1302.8 
                 (M + H)+ 
               
               
                 232 
                 SSC-AF-00 
                 2.144 
                 1407.9 
                 (M − H)− 
               
               
                 233 
                 SSC-TFA-07 
                 1.353 
                 1492.8 
                 (M + H)+ 
               
               
                 234 
                 SSC-AF-00 
                 2.144 
                 1397.6 
                 (M − H)− 
               
               
                 235 
                 SSC-FA-03 
                 1.708 
                 1435.7 
                 (M − H)− 
               
               
                 236 
                 SSC-AF-00 
                 2.132 
                 1400.0 
                 (M − H)− 
               
               
                 237 
                 SSC-AF-00 
                 2.264 
                 1366.9 
                 (M − H)− 
               
               
                 238 
                 SSC-TFA-07 
                 1.399 
                 1323.7 
                 (M + H)+ 
               
               
                 239 
                 SSC-FA-03 
                 1.887 
                 1527.8 
                 (M − H)− 
               
               
                 240 
                 SSC-AF-00 
                 2.152 
                 1508.8 
                 (M − H)− 
               
               
                 241 
                 SSC-A-FA-02 
                 6.756 
                 1364.7 
                 (M − H)− 
               
               
                 242 
                 SSC-TFA-07 
                 1.472 
                 1290.7 
                 (M + H)+ 
               
               
                 243 
                 SSC-FA-03 
                 1.543 
                 1472.8 
                 (M − H)− 
               
               
                 244 
                 SSC-FA-03 
                 1.719 
                 1360.7 
                 (M − H)− 
               
               
                 245 
                 SSC-AF-00 
                 2.096 
                 1513.9 
                 (M − H)− 
               
               
                 246 
                 SSC-FA-03 
                 1.875 
                 1383.8 
                 (M − H)− 
               
               
                 247 
                 SSC-FA-03 
                 1.857 
                 1485.8 
                 (M − H)− 
               
               
                 248 
                 SSC-TFA-07 
                 1.439 
                 1288.6 
                 (M + H)+ 
               
               
                 249 
                 SSC-FA-03 
                 2.119 
                 1465.9 
                 (M − H)− 
               
               
                 250 
                 SSC-FA-03 
                 2.155 
                 1485.9 
                 (M − H)− 
               
               
                 251 
                 SSC-AF-00 
                 2.177 
                 1523.0 
                 (M + H)+ 
               
               
                 252 
                 SSC-TFA-07 
                 1.353 
                 1362.7 
                 (M + H)+ 
               
               
                 253 
                 SSC-AF-00 
                 2.163 
                 1467.5 
                 (M − H)− 
               
               
                 254 
                 SSC-AF-00 
                 2.101 
                 1441.9 
                 (M − H)− 
               
               
                 255 
                 SSC-AF-00 
                 2.345 
                 1543.8 
                 (M + H)+ 
               
               
                 256 
                 SSC-FA-03 
                 1.793 
                 1399.7 
                 (M + H)+ 
               
               
                 257 
                 SSC-TFA-07 
                 1.484 
                 1334.8 
                 (M + H)+ 
               
               
                 258 
                 SSC-AF-00 
                 2.124 
                 1296.7 
                 (M − H)− 
               
               
                 259 
                 SSC-AF-00 
                 2.228 
                 1533.9 
                 (M − H)− 
               
               
                 260 
                 SSC-TFA-07 
                 1.472 
                 1346.8 
                 (M + H)+ 
               
               
                 261 
                 SSC-TFA-07 
                 1.489 
                 1302.8 
                 (M + H)+ 
               
               
                 262 
                 SSC-TFA-07 
                 1.489 
                 1274.8 
                 (M + H)+ 
               
               
                 263 
                 SSC-A-AF-01 
                 7.788 
                 1453.9 
                 (M − H)− 
               
               
                 264 
                 SSC-TFA-07 
                 1.405 
                 1276.7 
                 (M + H)+ 
               
               
                 265 
                 SSC-TFA-07 
                 1.405 
                 1299.8 
                 (M + H)+ 
               
               
                 266 
                 SSC-TFA-07 
                 1.377 
                 1343.7 
                 (M + H)+ 
               
               
                 267 
                 SSC-FA-03 
                 1.991 
                 1299.0 
                 (M − H)− 
               
               
                 268 
                 SSC-TFA-07 
                 1.423 
                 1276.7 
                 (M + H)+ 
               
               
                 269 
                 SSC-A-FA-02 
                 6.321 
                 1430.6 
                 (M + H)+ 
               
               
                 270 
                 SSC-AF-00 
                 2.216 
                 1449.8 
                 (M − H)− 
               
               
                 271 
                 SSC-TFA-07 
                 1.441 
                 1322.8 
                 (M + H)+ 
               
               
                 272 
                 SSC-FA-03 
                 1.839 
                 1501.8 
                 (M − H)− 
               
               
                 273 
                 SSC-TFA-07 
                 1.471 
                 1314.7 
                 (M + H)+ 
               
               
                 274 
                 SSC-AF-00 
                 2.152 
                 1399.5 
                 (M − H)− 
               
               
                 275 
                 SSC-TFA-07 
                 1.447 
                 1278.7 
                 (M + H)+ 
               
               
                 276 
                 SSC-AF-00 
                 2.097 
                 1503.8 
                 (M − H)− 
               
               
                 277 
                 SSC-FA-03 
                 2.051 
                 1413.8 
                 (M − H)− 
               
               
                 278 
                 SSC-FA-03 
                 1.804 
                 1408.7 
                 (M − H)− 
               
               
                 279 
                 SSC-A-FA-01 
                 5.560 
                 1434.0 
                 (M − H)− 
               
               
                 280 
                 SSC-AF-00 
                 2.143 
                 1409.6 
                 (M − H)− 
               
               
                 281 
                 SSC-TFA-07 
                 1.575 
                 1427.6 
                 (M + H)+ 
               
               
                 282 
                 SSC-FA-03 
                 2.008 
                 1456.0 
                 (M − H)− 
               
               
                 283 
                 SSC-AF-00 
                 2.156 
                 1489.9 
                 (M − H)− 
               
               
                 284 
                 SSC-AF-00 
                 2.107 
                 1395.9 
                 (M − H)− 
               
               
                 285 
                 SSC-TFA-07 
                 1.588 
                 1330.6 
                 (M + H)+ 
               
               
                 286 
                 SSC-TFA-07 
                 1.443 
                 1286.9 
                 (M + H)+ 
               
               
                 287 
                 SSC-TFA-07 
                 1.571 
                 1401.7 
                 (M + H)+ 
               
               
                 288 
                 SSC-AF-00 
                 2.097 
                 1395.9 
                 (M − H)− 
               
               
                 289 
                 SSC-FA-03 
                 1.705 
                 1372.0 
                 (M − H)− 
               
               
                 290 
                 SSC-TFA-07 
                 1.503 
                 1302.6 
                 (M + H)+ 
               
               
                 291 
                 SSC-FA-03 
                 1.815 
                 1302.5 
                 (M + H)+ 
               
               
                 292 
                 SSC-FA-03 
                 1.871 
                 1329.6 
                 (M − H)− 
               
               
                 293 
                 SSC-AF-00 
                 2.171 
                 1409.9 
                 (M − H)− 
               
               
                 294 
                 SSC-AF-00 
                 2.229 
                 1428.0 
                 (M − H)− 
               
               
                 295 
                 SSC-TFA-07 
                 1.471 
                 1443.7 
                 (M + H)+ 
               
               
                 296 
                 SSC-A-FA-02 
                 7.016 
                 1474.9 
                 (M − H)− 
               
               
                 297 
                 SSC-AF-00 
                 2.301 
                 1493.7 
                 (M − H)− 
               
               
                 298 
                 SSC-TFA-07 
                 1.512 
                 1385.8 
                 (M + H)+ 
               
               
                 299 
                 SSC-TFA-07 
                 1.471 
                 1320.8 
                 (M + H)+ 
               
               
                 300 
                 SSC-FA-03 
                 1.885 
                 1444.3 
                 (M − H)− 
               
               
                 301 
                 SSC-A-FA-01 
                 6.227 
                 1450.6 
                 (M + H)+ 
               
               
                 302 
                 SSC-AF-00 
                 2.095 
                 1425.9 
                 (M − H)− 
               
               
                 303 
                 SSC-A-FA-01 
                 5.293 
                 1419.8 
                 (M − H)− 
               
               
                 304 
                 SSC-AF-00 
                 2.164 
                 1481.7 
                 (M − H)− 
               
               
                 305 
                 SSC-TFA-07 
                 1.571 
                 1318.8 
                 (M + H)+ 
               
               
                 306 
                 SSC-TFA-07 
                 1.373 
                 1461.7 
                 (M + H)+ 
               
               
                 307 
                 SSC-AF-00 
                 2.171 
                 1397.5 
                 (M − H)− 
               
               
                 308 
                 SSC-A-FA-01 
                 5.464 
                 1407.8 
                 (M − H)− 
               
               
                 309 
                 SSC-FA-03 
                 1.932 
                 1427.5 
                 (M − H)− 
               
               
                 310 
                 SSC-AF-00 
                 2.147 
                 1342.4 
                 (M − H)− 
               
               
                 311 
                 SSC-TFA-07 
                 1.592 
                 1415.8 
                 (M + H)+ 
               
               
                 312 
                 SSC-TFA-07 
                 1.445 
                 1375.7 
                 (M + H)+ 
               
               
                 313 
                 SSC-FA-03 
                 1.773 
                 1381.6 
                 (M − H)− 
               
               
                 314 
                 SSC-FA-03 
                 1.821 
                 1371.9 
                 (M − H)− 
               
               
                 315 
                 SSC-TFA-07 
                 1.449 
                 1302.9 
                 (M + H)+ 
               
               
                 316 
                 SSC-AF-00 
                 2.040 
                 1359.9 
                 (M − H)− 
               
               
                 317 
                 SSC-FA-03 
                 1.871 
                 1415.5 
                 (M − H)− 
               
               
                 318 
                 SSC-TFA-07 
                 1.479 
                 1425.7 
                 (M + H)+ 
               
               
                 319 
                 SSC-A-FA-01 
                 6.677 
                 1468.6 
                 (M + H)+ 
               
               
                 320 
                 SSC-AF-00 
                 2.177 
                 1478.0 
                 (M − H)− 
               
               
                 321 
                 SSC-TFA-07 
                 1.633 
                 1441.7 
                 (M + H)+ 
               
               
                 322 
                 SSC-TFA-07 
                 1.444 
                 1350.8 
                 (M + H)+ 
               
               
                 323 
                 SSC-TFA-07 
                 1.339 
                 1260.7 
                 (M + H)+ 
               
               
                 324 
                 SSC-TFA-07 
                 1.636 
                 1407.7 
                 (M + H)+ 
               
               
                 325 
                 SSC-TFA-07 
                 1.404 
                 1359.7 
                 (M + H)+ 
               
               
                 326 
                 SSC-FA-03 
                 1.867 
                 1437.7 
                 (M − H)− 
               
               
                 327 
                 SSC-AF-00 
                 2.136 
                 1409.9 
                 (M − H)− 
               
               
                 328 
                 SSC-AF-00 
                 2.139 
                 1439.8 
                 (M − H)− 
               
               
                 329 
                 SSC-TFA-07 
                 1.587 
                 1348.7 
                 (M + H)+ 
               
               
                 330 
                 SSC-FA-03 
                 1.999 
                 1481.4 
                 (M − H)− 
               
               
                 331 
                 SSC-A-FA-01 
                 4.375 
                 1452.6 
                 (M − H)− 
               
               
                 332 
                 SSC-TFA-07 
                 1.465 
                 1320.8 
                 (M + H)+ 
               
               
                 333 
                 SSC-AF-00 
                 2.171 
                 1300.5 
                 (M − H)− 
               
               
                 334 
                 SSC-FA-03 
                 1.825 
                 1396.0 
                 (M − H)− 
               
               
                 335 
                 SSC-FA-03 
                 1.884 
                 1481.9 
                 (M − H)− 
               
               
                 336 
                 SSC-AF-00 
                 2.215 
                 1516.0 
                 (M − H)− 
               
               
                 337 
                 SSC-TFA-07 
                 1.457 
                 1288.7 
                 (M + H)+ 
               
               
                 338 
                 SSC-AF-00 
                 2.279 
                 1545.1 
                 (M − H)− 
               
               
                 339 
                 SSC-FA-03 
                 1.848 
                 1431.8 
                 (M − H)− 
               
               
                 340 
                 SSC-FA-03 
                 2.008 
                 1486.0 
                 (M − H)− 
               
               
                 341 
                 SSC-FA-03 
                 1.747 
                 1274.9 
                 (M − H)− 
               
               
                 342 
                 SSC-A-AF-01 
                 7.544 
                 1407.8 
                 (M − H)− 
               
               
                 343 
                 SSC-A-FA-01 
                 5.341 
                 1440.0 
                 (M − H)− 
               
               
                 344 
                 SSC-A-FA-01 
                 6.165 
                 1464.6 
                 (M + H)+ 
               
               
                 345 
                 SSC-A-FA-02 
                 7.005 
                 1466.7 
                 (M − H)− 
               
               
                 346 
                 SSC-FA-03 
                 1.988 
                 1435.8 
                 (M − H)− 
               
               
                 347 
                 SSC-TFA-07 
                 1.476 
                 1316.6 
                 (M + H)+ 
               
               
                 348 
                 SSC-A-AF-01 
                 7.915 
                 1430.6 
                 (M − H)− 
               
               
                 349 
                 SSC-AF-00 
                 2.224 
                 1424.0 
                 (M − H)− 
               
               
                 350 
                 SSC-AF-00 
                 2.160 
                 1437.8 
                 (M − H)− 
               
               
                 351 
                 SSC-TFA-07 
                 1.415 
                 1308.6 
                 (M + H)+ 
               
               
                 352 
                 SSC-FA-03 
                 1.889 
                 1427.7 
                 (M − H)− 
               
               
                 353 
                 SSC-FA-03 
                 1.852 
                 1473.9 
                 (M − H)− 
               
               
                 354 
                 SSC-FA-03 
                 1.845 
                 1322.9 
                 (M − H)− 
               
               
                 355 
                 SSC-AF-00 
                 2.135 
                 1470.8 
                 (M − H)− 
               
               
                 356 
                 SSC-AF-00 
                 2.203 
                 1425.8 
                 (M − H)− 
               
               
                 357 
                 SSC-TFA-07 
                 1.399 
                 1323.6 
                 (M + H)+ 
               
               
                 358 
                 SSC-AF-00 
                 2.173 
                 1423.8 
                 (M − H)− 
               
               
                 359 
                 SSC-A-FA-02 
                 6.141 
                 1358.7 
                 (M − H)− 
               
               
                 360 
                 SSC-TFA-07 
                 1.421 
                 1359.6 
                 (M + H)+ 
               
               
                 361 
                 SSC-FA-03 
                 1.651 
                 1204.8 
                 (M − H)− 
               
               
                 362 
                 SSC-A-FA-01 
                 6.135 
                 1452.6 
                 (M + H)+ 
               
               
                 363 
                 SSC-A-AF-01 
                 7.219 
                 1405.9 
                 (M − H)− 
               
               
                 364 
                 SSC-TFA-07 
                 1.505 
                 1306.8 
                 (M + H)+ 
               
               
                 365 
                 SSC-A-AF-02 
                 8.011 
                 1464.7 
                 (M + H)+ 
               
               
                 366 
                 SSC-FA-03 
                 1.927 
                 1331.0 
                 (M − H)− 
               
               
                 367 
                 SSC-FA-03 
                 1.817 
                 1453.5 
                 (M − H)− 
               
               
                 368 
                 SSC-FA-03 
                 1.896 
                 1411.6 
                 (M − H)− 
               
               
                 369 
                 SSC-FA-03 
                 1.691 
                 1258.5 
                 (M − H)− 
               
               
                 370 
                 SSC-FA-03 
                 1.915 
                 1514.0 
                 (M − H)− 
               
               
                 371 
                 SSC-A-FA-01 
                 6.021 
                 1420.6 
                 (M + H)+ 
               
               
                 372 
                 SSC-TFA-07 
                 1.364 
                 1391.9 
                 (M + H)+ 
               
               
                 373 
                 SSC-TFA-07 
                 1.281 
                 1348.8 
                 (M + H)+ 
               
               
                 374 
                 SSC-A-FA-02 
                 6.708 
                 1464.6 
                 (M − H)− 
               
               
                 375 
                 SSC-A-AF-02 
                 7.887 
                 1374.6 
                 (M + H)+ 
               
               
                 376 
                 SSC-AF-00 
                 2.172 
                 1523.8 
                 (M − H)− 
               
               
                 377 
                 SSC-A-FA-02 
                 6.900 
                 1468.7 
                 (M − H)− 
               
               
                 378 
                 SSC-FA-03 
                 1.827 
                 1395.9 
                 (M − H)− 
               
               
                 379 
                 SSC-AF-00 
                 2.132 
                 1516.9 
                 (M − H)− 
               
               
                 380 
                 SSC-AF-00 
                 2.172 
                 1371.8 
                 (M − H)− 
               
               
                 381 
                 SSC-AF-00 
                 2.092 
                 1413.9 
                 (M − H)− 
               
               
                 382 
                 SSC-AF-00 
                 2.049 
                 1341.6 
                 (M − H)− 
               
               
                 383 
                 SSC-TFA-07 
                 1.499 
                 1312.7 
                 (M + H)+ 
               
               
                 384 
                 SSC-AF-00 
                 2.155 
                 1482.8 
                 (M − H)− 
               
               
                 385 
                 SSC-FA-03 
                 1.955 
                 1489.8 
                 (M − H)− 
               
               
                 386 
                 SSC-FA-03 
                 1.863 
                 1310.6 
                 (M − H)− 
               
               
                 387 
                 SSC-FA-03 
                 1.912 
                 1481.9 
                 (M − H)− 
               
               
                 388 
                 SSC-AF-00 
                 2.147 
                 1463.9 
                 (M − H)− 
               
               
                 389 
                 SSC-FA-03 
                 1.560 
                 1520.9 
                 (M − H)− 
               
               
                 390 
                 SSC-FA-03 
                 1.808 
                 1438.1 
                 (M − H)− 
               
               
                 391 
                 SSC-AF-00 
                 2.205 
                 1438.0 
                 (M − H)− 
               
               
                 392 
                 SSC-AF-00 
                 2.283 
                 1482.0 
                 (M − H)− 
               
               
                 393 
                 SSC-AF-00 
                 2.169 
                 1411.9 
                 (M − H)− 
               
               
                 394 
                 SSC-AF-00 
                 2.156 
                 1414.0 
                 (M − H)− 
               
               
                 395 
                 SSC-TFA-07 
                 1.523 
                 1304.7 
                 (M + H)+ 
               
               
                 396 
                 SSC-FA-03 
                 1.647 
                 1230.4 
                 (M − H)− 
               
               
                 397 
                 SSC-AF-00 
                 2.140 
                 1427.9 
                 (M − H)− 
               
               
                 398 
                 SSC-AA-20 
                 2.108 
                 1349.8 
                 (M − H)− 
               
               
                 399 
                 SSC-TFA-07 
                 1.568 
                 1439.7 
                 (M + H)+ 
               
               
                 400 
                 SSC-A-FA-01 
                 5.539 
                 1433.8 
                 (M − H)− 
               
               
                 401 
                 SSC-A-AF-02 
                 8.128 
                 1462.6 
                 (M + H)+ 
               
               
                 402 
                 SSC-TFA-07 
                 1.484 
                 1288.7 
                 (M + H)+ 
               
               
                 403 
                 SSC-AF-00 
                 2.113 
                 1443.8 
                 (M − H)− 
               
               
                 404 
                 SSC-FA-03 
                 1.856 
                 1335.0 
                 (M − H)− 
               
               
                 405 
                 SSC-TFA-07 
                 1.563 
                 1318.7 
                 (M + H)+ 
               
               
                 406 
                 SSC-TFA-07 
                 1.393 
                 1322.8 
                 (M + H)+ 
               
               
                 407 
                 SSC-TFA-07 
                 1.401 
                 1318.8 
                 (M + H)+ 
               
               
                 408 
                 SSC-FA-03 
                 1.739 
                 1428.0 
                 (M − H)− 
               
               
                 409 
                 SSC-AF-00 
                 2.196 
                 1424.1 
                 (M − H)− 
               
               
                 410 
                 SSC-FA-03 
                 1.805 
                 1447.9 
                 (M − H)− 
               
               
                 411 
                 SSC-AF-00 
                 2.215 
                 1437.9 
                 (M − H)− 
               
               
                 412 
                 SSC-AF-00 
                 2.128 
                 1272.9 
                 (M − H)− 
               
               
                 413 
                 SSC-FA-03 
                 1.704 
                 1218.8 
                 (M − H)− 
               
               
                 414 
                 SSC-TFA-07 
                 1.475 
                 1270.8 
                 (M + H)+ 
               
               
                 415 
                 SSC-FA-03 
                 1.919 
                 1427.9 
                 (M − H)− 
               
               
                 416 
                 SSC-AF-00 
                 2.208 
                 1340.4 
                 (M − H)− 
               
               
                 417 
                 SSC-AF-00 
                 2.160 
                 1385.9 
                 (M − H)− 
               
               
                 418 
                 SSC-TFA-07 
                 1.449 
                 1344.6 
                 (M + H)+ 
               
               
                 419 
                 SSC-FA-03 
                 1.777 
                 1475.8 
                 (M − H)− 
               
               
                 420 
                 SSC-AF-00 
                 2.168 
                 1328.5 
                 (M − H)− 
               
               
                 421 
                 SSC-TFA-07 
                 1.497 
                 1399.8 
                 (M + H)+ 
               
               
                 422 
                 SSC-AF-00 
                 2.120 
                 1541.8 
                 (M − H)− 
               
               
                 423 
                 SSC-TFA-07 
                 1.504 
                 1457.7 
                 (M + H)+ 
               
               
                 424 
                 SSC-A-FA-02 
                 6.431 
                 1379.1 
                 (M − H)− 
               
               
                 425 
                 SSC-FA-03 
                 2.051 
                 1489.8 
                 (M − H)− 
               
               
                 426 
                 SSC-FA-03 
                 1.853 
                 1415.7 
                 (M − H)− 
               
               
                 427 
                 SSC-FA-03 
                 1.811 
                 1387.9 
                 (M − H)− 
               
               
                 428 
                 SSC-AF-00 
                 2.296 
                 1516.1 
                 (M − H)− 
               
               
                 429 
                 SSC-AF-00 
                 2.112 
                 1260.5 
                 (M + H)+ 
               
               
                 430 
                 SSC-A-FA-02 
                 6.889 
                 1476.6 
                 (M − H)− 
               
               
                 431 
                 SSC-AF-00 
                 2.217 
                 1383.7 
                 (M − H)− 
               
               
                 432 
                 SSC-A-AF-02 
                 8.151 
                 1422.8 
                 (M − H)− 
               
               
                 433 
                 SSC-AF-00 
                 2.205 
                 1489.0 
                 (M − H)− 
               
               
                 434 
                 SSC-FA-03 
                 1.833 
                 1425.9 
                 (M − H)− 
               
               
                 435 
                 SSC-TFA-07 
                 1.851 
                 1514.0 
                 (M + H)+ 
               
               
                 436 
                 SSC-AF-00 
                 2.161 
                 1300.8 
                 (M − H)− 
               
               
                 437 
                 SSC-FA-03 
                 1.891 
                 1411.9 
                 (M − H)− 
               
               
                 438 
                 SSC-TFA-07 
                 1.529 
                 1401.8 
                 (M + H)+ 
               
               
                 439 
                 SSC-TFA-07 
                 1.525 
                 1304.7 
                 (M + H)+ 
               
               
                 440 
                 SSC-FA-03 
                 1.947 
                 1422.7 
                 (M − H)− 
               
               
                 441 
                 SSC-FA-03 
                 1.827 
                 1478.5 
                 (M − H)− 
               
               
                 442 
                 SSC-AF-00 
                 2.140 
                 1481.9 
                 (M − H)− 
               
               
                 443 
                 SSC-FA-03 
                 2.117 
                 1442.0 
                 (M + H)+ 
               
               
                 444 
                 SSC-AF-00 
                 2.141 
                 1494.8 
                 (M − H)− 
               
               
                 445 
                 SSC-FA-03 
                 1.740 
                 1445.4 
                 (M + H)+ 
               
               
                 446 
                 SSC-AF-00 
                 2.113 
                 1383.9 
                 (M − H)− 
               
               
                 447 
                 SSC-AF-00 
                 2.152 
                 1397.6 
                 (M + H)+ 
               
               
                 448 
                 SSC-TFA-07 
                 1.373 
                 1349.7 
                 (M + H)+ 
               
               
                 449 
                 SSC-FA-03 
                 2.101 
                 1490.0 
                 (M − H)− 
               
               
                 450 
                 SSC-AF-00 
                 2.127 
                 1413.5 
                 (M − H)− 
               
               
                 451 
                 SSC-AF-00 
                 2.171 
                 1411.9 
                 (M − H)− 
               
               
                 452 
                 SSC-FA-03 
                 1.911 
                 1423.9 
                 (M − H)− 
               
               
                 453 
                 SSC-AF-00 
                 2.163 
                 1411.9 
                 (M − H)− 
               
               
                 454 
                 SSC-FA-03 
                 1.801 
                 1288.7 
                 (M − H)− 
               
               
                 455 
                 SSC-TFA-07 
                 1.540 
                 1328.7 
                 (M + H)+ 
               
               
                 456 
                 SSC-TFA-07 
                 1.485 
                 1316.7 
                 (M + H)+ 
               
               
                 457 
                 SSC-TFA-07 
                 1.401 
                 1415.6 
                 (M + H)+ 
               
               
                 458 
                 SSC-AF-00 
                 2.079 
                 1350.0 
                 (M − H)− 
               
               
                 459 
                 SSC-FA-03 
                 1.852 
                 1497.8 
                 (M − H)− 
               
               
                 460 
                 SSC-FA-03 
                 1.583 
                 1476.9 
                 (M − H)− 
               
               
                 461 
                 SSC-AF-00 
                 2.160 
                 1452.0 
                 (M − H)− 
               
               
                 462 
                 SSC-A-AF-02 
                 7.828 
                 1428.6 
                 (M + H)+ 
               
               
                 463 
                 SSC-FA-03 
                 1.939 
                 1509.0 
                 (M − H)− 
               
               
                 464 
                 SSC-AF-00 
                 2.159 
                 1340.7 
                 (M − H)− 
               
               
                 465 
                 SSC-TFA-07 
                 1.485 
                 1314.6 
                 (M + H)+ 
               
               
                 466 
                 SSC-A-FA-02 
                 6.693 
                 1478.6 
                 (M + H)+ 
               
               
                 467 
                 SSC-TFA-07 
                 1.298 
                 1357.6 
                 (M + H)+ 
               
               
                 468 
                 SSC-TFA-07 
                 1.452 
                 1373.7 
                 (M + H)+ 
               
               
                 469 
                 SSC-FA-03 
                 1.913 
                 1467.6 
                 (M − H)− 
               
               
                 470 
                 SSC-AF-00 
                 2.191 
                 1430.0 
                 (M − H)− 
               
               
                 471 
                 SSC-TFA-07 
                 1.477 
                 1354.7 
                 (M + H)+ 
               
               
                 472 
                 SSC-FA-03 
                 2.063 
                 1488.1 
                 (M − H)− 
               
               
                 473 
                 SSC-AA-20 
                 2.161 
                 1419.7 
                 (M − H)− 
               
               
                 474 
                 SSC-TFA-07 
                 1.496 
                 1314.7 
                 (M + H)+ 
               
               
                 475 
                 SSC-A-FA-02 
                 6.823 
                 1416.7 
                 (M + H)+ 
               
               
                 476 
                 SSC-TFA-07 
                 1.559 
                 1427.8 
                 (M + H)+ 
               
               
                 477 
                 SSC-FA-03 
                 1.681 
                 1532.8 
                 (M + H)+ 
               
               
                 478 
                 SSC-FA-03 
                 2.093 
                 1468.1 
                 (M − H)− 
               
               
                 479 
                 SSC-FA-03 
                 2.249 
                 1601.0 
                 (M + H)+ 
               
               
                 480 
                 SSC-AF-00 
                 2.193 
                 1517.1 
                 (M − H)− 
               
               
                 481 
                 SSC-FA-03 
                 1.877 
                 1346.9 
                 (M − H)− 
               
               
                 482 
                 SSC-FA-03 
                 1.833 
                 1280.9 
                 (M − H)− 
               
               
                 483 
                 SSC-AF-00 
                 2.197 
                 1521.8 
                 (M − H)− 
               
               
                 484 
                 SSC-AF-00 
                 2.145 
                 1427.8 
                 (M − H)− 
               
               
                 485 
                 SSC-FA-03 
                 2.045 
                 1470.1 
                 (M − H)− 
               
               
                 486 
                 SSC-A-FA-01 
                 6.473 
                 1478.7 
                 (M + H)+ 
               
               
                 487 
                 SSC-AF-00 
                 2.092 
                 1373.9 
                 (M − H)− 
               
               
                 488 
                 SSC-TFA-07 
                 1.521 
                 1316.8 
                 (M + H)+ 
               
               
                 489 
                 SSC-AF-00 
                 2.043 
                 1295.5 
                 (M + H)+ 
               
               
                 490 
                 SSC-TFA-07 
                 1.429 
                 1300.6 
                 (M + H)+ 
               
               
                 491 
                 SSC-FA-03 
                 1.884 
                 1382.1 
                 (M − H)− 
               
               
                 492 
                 SSC-AF-00 
                 2.172 
                 1439.9 
                 (M − H)− 
               
               
                 493 
                 SSC-FA-03 
                 1.889 
                 1495.0 
                 (M − H)− 
               
               
                 494 
                 SSC-A-FA-02 
                 6.515 
                 1376.6 
                 (M − H)− 
               
               
                 495 
                 SSC-FA-03 
                 2.001 
                 1425.8 
                 (M − H)− 
               
               
                 496 
                 SSC-AF-00 
                 2.163 
                 1455.9 
                 (M − H)− 
               
               
                 497 
                 SSC-AF-00 
                 2.144 
                 1427.9 
                 (M − H)− 
               
               
                 498 
                 SSC-FA-03 
                 2.076 
                 1571.7 
                 (M − H)− 
               
               
                 499 
                 SSC-TFA-07 
                 1.321 
                 1343.7 
                 (M + H)+ 
               
               
                 500 
                 SSC-AF-00 
                 2.239 
                 1510.8 
                 (M − H)− 
               
               
                 501 
                 SSC-AF-00 
                 2.197 
                 1328.5 
                 (M − H)− 
               
               
                 502 
                 SSC-TFA-07 
                 1.307 
                 1451.8 
                 (M + H)+ 
               
               
                 503 
                 SSC-A-FA-02 
                 6.264 
                 1418.6 
                 (M + H)+ 
               
               
                 504 
                 SSC-TFA-07 
                 1.521 
                 1304.8 
                 (M + H)+ 
               
               
                 505 
                 SSC-A-AF-02 
                 8.020 
                 1452.6 
                 (M − H)− 
               
               
                 506 
                 SSC-A-FA-01 
                 5.477 
                 1447.7 
                 (M + H)+ 
               
               
                 507 
                 SSC-AF-00 
                 2.048 
                 1345.5 
                 (M − H)− 
               
               
                 508 
                 SSC-TFA-07 
                 1.421 
                 1373.6 
                 (M + H)+ 
               
               
                 509 
                 SSC-A-FA-01 
                 5.879 
                 1501.7 
                 (M − H)− 
               
               
                 510 
                 SSC-A-FA-02 
                 6.465 
                 1373.1 
                 (M − H)− 
               
               
                 511 
                 SSC-TFA-07 
                 1.356 
                 1248.7 
                 (M + H)+ 
               
               
                 512 
                 SSC-TFA-07 
                 1.531 
                 1362.6 
                 (M + H)+ 
               
               
                 513 
                 SSC-AA-20 
                 2.085 
                 1488.7 
                 (M + H)+ 
               
               
                 514 
                 SSC-FA-03 
                 2.116 
                 1487.9 
                 (M − H)− 
               
               
                 515 
                 SSC-FA-03 
                 1.853 
                 1423.9 
                 (M − H)− 
               
               
                 516 
                 SSC-FA-03 
                 2.004 
                 1286.9 
                 (M − H)− 
               
               
                 517 
                 SSC-TFA-07 
                 1.279 
                 1454.7 
                 (M + H)+ 
               
               
                 518 
                 SSC-AF-00 
                 2.212 
                 1496.0 
                 (M − H)− 
               
               
                 519 
                 SSC-FA-03 
                 1.549 
                 1422.8 
                 (M − H)− 
               
               
                 520 
                 SSC-TFA-07 
                 1.459 
                 1276.7 
                 (M + H)+ 
               
               
                 521 
                 SSC-TFA-07 
                 1.375 
                 1284.7 
                 (M + H)+ 
               
               
                 522 
                 SSC-TFA-07 
                 1.420 
                 1359.7 
                 (M + H)+ 
               
               
                 523 
                 SSC-FA-03 
                 2.113 
                 1491.9 
                 (M − H)− 
               
               
                 524 
                 SSC-FA-03 
                 1.993 
                 1437.9 
                 (M − H)− 
               
               
                 525 
                 SSC-A-AF-02 
                 8.091 
                 1406.6 
                 (M − H)− 
               
               
                 526 
                 SSC-AF-00 
                 2.159 
                 1411.8 
                 (M − H)− 
               
               
                 527 
                 SSC-FA-03 
                 2.204 
                 1515.9 
                 (M − H)− 
               
               
                 528 
                 SSC-FA-03 
                 2.001 
                 1366.9 
                 (M − H)− 
               
               
                 529 
                 SSC-AF-00 
                 2.140 
                 1318.5 
                 (M − H)− 
               
               
                 530 
                 SSC-TFA-07 
                 1.513 
                 1359.7 
                 (M + H)+ 
               
               
                 531 
                 SSC-AF-00 
                 2.164 
                 1362.9 
                 (M − H)− 
               
               
                 532 
                 SSC-AF-00 
                 2.167 
                 1397.9 
                 (M − H)− 
               
               
                 533 
                 SSC-TFA-07 
                 1.463 
                 1385.6 
                 (M + H)+ 
               
               
                 534 
                 SSC-FA-03 
                 1.917 
                 1411.7 
                 (M − H)− 
               
               
                 535 
                 SSC-AF-00 
                 2.195 
                 1441.9 
                 (M − H)− 
               
               
                 536 
                 SSC-TFA-07 
                 1.500 
                 1411.8 
                 (M + H)+ 
               
               
                 537 
                 SSC-AF-00 
                 2.209 
                 1329.0 
                 (M − H)− 
               
               
                 538 
                 SSC-AF-00 
                 2.113 
                 1324.9 
                 (M − H)− 
               
               
                 539 
                 SSC-FA-03 
                 1.895 
                 1314.5 
                 (M − H)− 
               
               
                 540 
                 SSC-TFA-07 
                 1.427 
                 1256.7 
                 (M + H)+ 
               
               
                 541 
                 SSC-A-FA-02 
                 6.353 
                 1434.7 
                 (M − H)− 
               
               
                 542 
                 SSC-TFA-07 
                 1.555 
                 1316.7 
                 (M + H)+ 
               
               
                 543 
                 SSC-FA-03 
                 2.103 
                 1453.9 
                 (M − H)− 
               
               
                 544 
                 SSC-TFA-07 
                 1.445 
                 1415.7 
                 (M + H)+ 
               
               
                 545 
                 SSC-FA-03 
                 1.812 
                 1529.9 
                 (M − H)− 
               
               
                 546 
                 SSC-TFA-07 
                 1.501 
                 1336.9 
                 (M + H)+ 
               
               
                 547 
                 SSC-A-FA-02 
                 6.729 
                 1448.7 
                 (M − H)− 
               
               
                 548 
                 SSC-AF-00 
                 2.153 
                 1399.6 
                 (M − H)− 
               
               
                 549 
                 SSC-AF-00 
                 2.147 
                 1326.7 
                 (M − H)− 
               
               
                 550 
                 SSC-TFA-07 
                 1.451 
                 1288.7 
                 (M + H)+ 
               
               
                 551 
                 SSC-FA-03 
                 1.984 
                 1422.0 
                 (M − H)− 
               
               
                 552 
                 SSC-AF-00 
                 2.256 
                 1466.0 
                 (M − H)− 
               
               
                 553 
                 SSC-AF-00 
                 2.183 
                 1409.9 
                 (M − H)− 
               
               
                 554 
                 SSC-FA-03 
                 1.869 
                 1381.9 
                 (M − H)− 
               
               
                 555 
                 SSC-AF-00 
                 2.052 
                 1356.0 
                 (M − H)− 
               
               
                 556 
                 SSC-AF-00 
                 2.143 
                 1473.5 
                 (M − H)− 
               
               
                 557 
                 SSC-FA-03 
                 1.496 
                 1432.8 
                 (M − H)− 
               
               
                 558 
                 SSC-TFA-07 
                 1.637 
                 1441.8 
                 (M + H)+ 
               
               
                 559 
                 SSC-FA-03 
                 1.859 
                 1407.9 
                 (M − H)− 
               
               
                 560 
                 SSC-TFA-07 
                 1.336 
                 1258.7 
                 (M + H)+ 
               
               
                 561 
                 SSC-TFA-07 
                 1.504 
                 1399.7 
                 (M + H)+ 
               
               
                 562 
                 SSC-FA-03 
                 2.024 
                 1437.9 
                 (M − H)− 
               
               
                 563 
                 SSC-AF-00 
                 2.192 
                 1435.6 
                 (M − H)− 
               
               
                 564 
                 SSC-TFA-07 
                 1.365 
                 1309.6 
                 (M + H)+ 
               
               
                 565 
                 SSC-TFA-07 
                 1.412 
                 1300.7 
                 (M + H)+ 
               
               
                 566 
                 SSC-AF-00 
                 2.193 
                 1396.7 
                 (M − H)− 
               
               
                 567 
                 SSC-FA-03 
                 1.800 
                 1402.0 
                 (M − H)− 
               
               
                 568 
                 SSC-FA-03 
                 1.837 
                 1385.9 
                 (M − H)− 
               
               
                 569 
                 SSC-TFA-07 
                 1.509 
                 1316.6 
                 (M + H)+ 
               
               
                 570 
                 SSC-TFA-07 
                 1.520 
                 1328.5 
                 (M + H)+ 
               
               
                 571 
                 SSC-A-FA-01 
                 5.515 
                 1425.7 
                 (M + H)+ 
               
               
                 572 
                 SSC-AF-00 
                 2.261 
                 1465.6 
                 (M − H)− 
               
               
                 573 
                 SSC-A-FA-02 
                 6.337 
                 1396.6 
                 (M + H)+ 
               
               
                 574 
                 SSC-A-FA-02 
                 6.388 
                 1452.6 
                 (M + H)+ 
               
               
                 575 
                 SSC-FA-03 
                 1.847 
                 1385.9 
                 (M − H)− 
               
               
                 576 
                 SSC-AF-00 
                 2.116 
                 1220.5 
                 (M − H)− 
               
               
                 577 
                 SSC-TFA-07 
                 1.644 
                 1455.8 
                 (M + H)+ 
               
               
                 578 
                 SSC-TFA-07 
                 1.540 
                 1338.8 
                 (M + H)+ 
               
               
                 579 
                 SSC-A-FA-02 
                 6.495 
                 1430.6 
                 (M + H)+ 
               
               
                 580 
                 SSC-TFA-07 
                 1.491 
                 1314.7 
                 (M + H)+ 
               
               
                 581 
                 SSC-TFA-07 
                 1.439 
                 1274.6 
                 (M + H)+ 
               
               
                 582 
                 SSC-TFA-07 
                 1.307 
                 1417.8 
                 (M + H)+ 
               
               
                 583 
                 SSC-TFA-07 
                 1.664 
                 1368.8 
                 (M + H)+ 
               
               
                 584 
                 SSC-AF-00 
                 2.133 
                 1324.5 
                 (M − H)− 
               
               
                 585 
                 SSC-AF-00 
                 2.179 
                 1441.9 
                 (M − H)− 
               
               
                 586 
                 SSC-TFA-07 
                 1.572 
                 1318.7 
                 (M + H)+ 
               
               
                 587 
                 SSC-AF-00 
                 2.147 
                 1416.9 
                 (M − H)− 
               
               
                 588 
                 SSC-TFA-07 
                 1.496 
                 1288.7 
                 (M + H)+ 
               
               
                 589 
                 SSC-FA-03 
                 1.799 
                 1499.9 
                 (M − H)− 
               
               
                 590 
                 SSC-AF-00 
                 2.229 
                 1499.0 
                 (M − H)− 
               
               
                 591 
                 SSC-FA-03 
                 1.967 
                 1399.9 
                 (M − H)− 
               
               
                 592 
                 SSC-FA-03 
                 2.153 
                 1534.9 
                 (M − H)− 
               
               
                 593 
                 SSC-TFA-07 
                 1.581 
                 1330.7 
                 (M + H)+ 
               
               
                 594 
                 SSC-A-FA-02 
                 6.632 
                 1461.0 
                 (M − H)− 
               
               
                 595 
                 SSC-AF-00 
                 2.205 
                 1342.7 
                 (M + H)+ 
               
               
                 596 
                 SSC-AF-00 
                 2.173 
                 1469.9 
                 (M − H)− 
               
               
                 597 
                 SSC-FA-03 
                 1.824 
                 1328.5 
                 (M − H)− 
               
               
                 598 
                 SSC-AF-00 
                 2.181 
                 1336.9 
                 (M − H)− 
               
               
                 599 
                 SSC-TFA-07 
                 1.440 
                 1397.8 
                 (M + H)+ 
               
               
                 600 
                 SSC-TFA-07 
                 1.587 
                 1415.8 
                 (M + H)+ 
               
               
                 601 
                 SSC-AF-00 
                 2.179 
                 1272.5 
                 (M − H)− 
               
               
                 602 
                 SSC-AF-00 
                 2.152 
                 1302.7 
                 (M + H)+ 
               
               
                 603 
                 SSC-FA-03 
                 1.940 
                 1427.9 
                 (M − H)− 
               
               
                 604 
                 SSC-FA-03 
                 1.655 
                 1427.7 
                 (M − H)− 
               
               
                 605 
                 SSC-FA-03 
                 1.852 
                 1360.9 
                 (M − H)− 
               
               
                 606 
                 SSC-A-AF-01 
                 7.861 
                 1470.7 
                 (M + H)+ 
               
               
                 607 
                 SSC-FA-03 
                 1.825 
                 1373.6 
                 (M − H)− 
               
               
                 608 
                 SSC-TFA-07 
                 1.503 
                 1304.7 
                 (M + H)+ 
               
               
                 609 
                 SSC-AA-20 
                 2.107 
                 1389.5 
                 (M − H)− 
               
               
                 610 
                 SSC-TFA-07 
                 1.485 
                 1411.7 
                 (M + H)+ 
               
               
                 611 
                 SSC-A-FA-02 
                 6.413 
                 1428.6 
                 (M + H)+ 
               
               
                 612 
                 SSC-TFA-07 
                 1.217 
                 1301.6 
                 (M + H)+ 
               
               
                 613 
                 SSC-TFA-07 
                 1.297 
                 1324.0 
                 (M + H)+ 
               
               
                 614 
                 SSC-AF-00 
                 2.267 
                 1547.0 
                 (M − H)− 
               
               
                 615 
                 SSC-TFA-07 
                 1.597 
                 1342.8 
                 (M + H)+ 
               
               
                 616 
                 SSC-FA-03 
                 1.971 
                 1489.8 
                 (M − H)− 
               
               
                 617 
                 SSC-AF-00 
                 2.172 
                 1496.0 
                 (M − H)− 
               
               
                 618 
                 SSC-FA-03 
                 1.793 
                 1313.6 
                 (M − H)− 
               
               
                 619 
                 SSC-FA-03 
                 1.884 
                 1441.9 
                 (M − H)− 
               
               
                 620 
                 SSC-TFA-07 
                 1.511 
                 1389.7 
                 (M + H)+ 
               
               
                 621 
                 SSC-AF-00 
                 2.121 
                 1246.8 
                 (M − H)− 
               
               
                 622 
                 SSC-A-AF-01 
                 7.701 
                 1472.0 
                 (M + H)+ 
               
               
                 623 
                 SSC-FA-03 
                 1.833 
                 1387.9 
                 (M − H)− 
               
               
                 624 
                 SSC-AF-00 
                 2.131 
                 1401.7 
                 (M − H)− 
               
               
                 625 
                 SSC-AF-00 
                 2.081 
                 1315.6 
                 (M − H)− 
               
               
                 626 
                 SSC-A-FA-02 
                 6.673 
                 1396.6 
                 (M + H)+ 
               
               
                 627 
                 SSC-AF-00 
                 2.200 
                 1425.9 
                 (M − H)− 
               
               
                 628 
                 SSC-A-FA-02 
                 6.727 
                 1393.1 
                 (M − H)− 
               
               
                 629 
                 SSC-TFA-07 
                 1.608 
                 1344.7 
                 (M + H)+ 
               
               
                 630 
                 SSC-AF-00 
                 2.163 
                 1501.8 
                 (M − H)− 
               
               
                 631 
                 SSC-AF-00 
                 2.148 
                 1449.9 
                 (M − H)− 
               
               
                 632 
                 SSC-AA-20 
                 2.149 
                 1332.7 
                 (M + H)+ 
               
               
                 633 
                 SSC-FA-03 
                 1.873 
                 1310.1 
                 (M − H)− 
               
               
                 634 
                 SSC-AA-20 
                 2.128 
                 1475.6 
                 (M − H)− 
               
               
                 635 
                 SSC-TFA-07 
                 1.304 
                 1423.7 
                 (M + H)+ 
               
               
                 636 
                 SSC-FA-03 
                 1.824 
                 1413.9 
                 (M − H)− 
               
               
                 637 
                 SSC-TFA-07 
                 1.479 
                 1463.5 
                 (M + H)+ 
               
               
                 638 
                 SSC-FA-03 
                 1.851 
                 1486.0 
                 (M − H)− 
               
               
                 639 
                 SSC-AF-00 
                 2.179 
                 1441.8 
                 (M − H)− 
               
               
                 640 
                 SSC-A-FA-01 
                 6.267 
                 1462.6 
                 (M + H)+ 
               
               
                 641 
                 SSC-TFA-07 
                 1.413 
                 1264.7 
                 (M + H)+ 
               
               
                 642 
                 SSC-TFA-07 
                 1.615 
                 1453.7 
                 (M + H)+ 
               
               
                 643 
                 SSC-AF-00 
                 2.321 
                 1495.6 
                 (M − H)− 
               
               
                 644 
                 SSC-TFA-07 
                 1.489 
                 1304.7 
                 (M + H)+ 
               
               
                 645 
                 SSC-TFA-07 
                 1.440 
                 1326.7 
                 (M + H)+ 
               
               
                 646 
                 SSC-TFA-07 
                 1.329 
                 1355.9 
                 (M + H)+ 
               
               
                 647 
                 SSC-FA-03 
                 1.912 
                 1451.9 
                 (M − H)− 
               
               
                 648 
                 SSC-FA-03 
                 1.832 
                 1334.5 
                 (M − H)− 
               
               
                 649 
                 SSC-TFA-07 
                 1.460 
                 1276.8 
                 (M + H)+ 
               
               
                 650 
                 SSC-AF-00 
                 2.201 
                 1441.9 
                 (M − H)− 
               
               
                 651 
                 SSC-FA-03 
                 1.701 
                 1244.5 
                 (M − H)− 
               
               
                 652 
                 SSC-A-FA-01 
                 6.589 
                 1476.6 
                 (M + H)+ 
               
               
                 653 
                 SSC-AF-00 
                 2.151 
                 1465.9 
                 (M + H)+ 
               
               
                 654 
                 SSC-TFA-07 
                 1.339 
                 1292.7 
                 (M + H)+ 
               
               
                 655 
                 SSC-A-FA-01 
                 3.989 
                 1442.7 
                 (M + H)+ 
               
               
                 656 
                 SSC-AF-00 
                 2.253 
                 1531.1 
                 (M − H)− 
               
               
                 657 
                 SSC-TFA-07 
                 1.404 
                 1375.6 
                 (M + H)+ 
               
               
                 658 
                 SSC-TFA-07 
                 1.424 
                 1288.7 
                 (M + H)+ 
               
               
                 659 
                 SSC-AF-00 
                 2.077 
                 1295.8 
                 (M − H)− 
               
               
                 660 
                 SSC-A-FA-01 
                 4.956 
                 1383.6 
                 (M + H)+ 
               
               
                 661 
                 SSC-AF-00 
                 2.248 
                 1470.0 
                 (M − H)− 
               
               
                 662 
                 SSC-AF-00 
                 2.225 
                 1455.9 
                 (M − H)− 
               
               
                 663 
                 SSC-TFA-07 
                 1.483 
                 1302.8 
                 (M + H)+ 
               
               
                 664 
                 SSC-TFA-07 
                 1.243 
                 1230.8 
                 (M + H)+ 
               
               
                 665 
                 SSC-AF-00 
                 2.147 
                 1288.7 
                 (M − H)− 
               
               
                 666 
                 SSC-FA-03 
                 1.857 
                 1300.6 
                 (M + H)+ 
               
               
                 667 
                 SSC-FA-03 
                 1.996 
                 1439.8 
                 (M − H)− 
               
               
                 668 
                 SSC-A-FA-01 
                 6.295 
                 1442.6 
                 (M + H)+ 
               
               
                 669 
                 SSC-TFA-07 
                 1.495 
                 1338.6 
                 (M + H)+ 
               
               
                 670 
                 SSC-TFA-07 
                 1.437 
                 1369.7 
                 (M + H)+ 
               
               
                 671 
                 SSC-FA-03 
                 1.800 
                 1308.5 
                 (M + H)+ 
               
               
                 672 
                 SSC-FA-03 
                 1.963 
                 1438.0 
                 (M − H)− 
               
               
                 673 
                 SSC-A-AF-02 
                 8.123 
                 1450.7 
                 (M + H)+ 
               
               
                 674 
                 SSC-AF-00 
                 2.135 
                 1396.1 
                 (M − H)− 
               
               
                 675 
                 SSC-TFA-07 
                 1.479 
                 1415.8 
                 (M + H)+ 
               
               
                 676 
                 SSC-TFA-07 
                 1.665 
                 1483.7 
                 (M + H)+ 
               
               
                 677 
                 SSC-FA-03 
                 1.864 
                 1398.0 
                 (M − H)− 
               
               
                 678 
                 SSC-FA-03 
                 1.865 
                 1431.6 
                 (M − H)− 
               
               
                 679 
                 SSC-A-FA-01 
                 5.848 
                 1494.7 
                 (M + H)+ 
               
               
                 680 
                 SSC-AF-00 
                 2.124 
                 1453.8 
                 (M − H)− 
               
               
                 681 
                 SSC-FA-03 
                 1.824 
                 1422.0 
                 (M − H)− 
               
               
                 682 
                 SSC-AF-00 
                 2.171 
                 1504.6 
                 (M − H)− 
               
               
                 683 
                 SSC-FA-03 
                 1.840 
                 1501.9 
                 (M − H)− 
               
               
                 684 
                 SSC-AF-00 
                 2.069 
                 1385.5 
                 (M − H)− 
               
               
                 685 
                 SSC-FA-03 
                 1.668 
                 1299.6 
                 (M − H)− 
               
               
                 686 
                 SSC-TFA-07 
                 1.584 
                 1318.8 
                 (M + H)+ 
               
               
                 687 
                 SSC-TFA-07 
                 1.479 
                 1338.8 
                 (M + H)+ 
               
               
                 688 
                 SSC-FA-03 
                 2.045 
                 1471.9 
                 (M − H)− 
               
               
                 689 
                 SSC-FA-03 
                 2.015 
                 1437.8 
                 (M − H)− 
               
               
                 690 
                 SSC-FA-03 
                 1.925 
                 1415.9 
                 (M − H)− 
               
               
                 691 
                 SSC-FA-03 
                 1.989 
                 1415.8 
                 (M − H)− 
               
               
                 692 
                 SSC-FA-03 
                 2.217 
                 1485.9 
                 (M − H)− 
               
               
                 693 
                 SSC-AF-00 
                 2.083 
                 1419.5 
                 (M + H)+ 
               
               
                 694 
                 SSC-FA-03 
                 1.933 
                 1304.6 
                 (M + H)+ 
               
               
                 695 
                 SSC-A-FA-02 
                 6.256 
                 1422.7 
                 (M − H)− 
               
               
                 696 
                 SSC-AF-00 
                 2.247 
                 1517.8 
                 (M − H)− 
               
               
                 697 
                 SSC-TFA-07 
                 1.360 
                 1248.6 
                 (M + H)+ 
               
               
                 698 
                 SSC-A-FA-02 
                 6.627 
                 1461.0 
                 (M − H)− 
               
               
                 699 
                 SSC-AF-00 
                 2.255 
                 1467.6 
                 (M − H)− 
               
               
                 700 
                 SSC-FA-03 
                 1.904 
                 1423.6 
                 (M − H)− 
               
               
                 701 
                 SSC-AF-00 
                 2.187 
                 1465.8 
                 (M − H)− 
               
               
                 702 
                 SSC-FA-03 
                 1.851 
                 1401.7 
                 (M − H)− 
               
               
                 703 
                 SSC-AF-00 
                 2.180 
                 1514.0 
                 (M + H)+ 
               
               
                 704 
                 SSC-A-FA-02 
                 6.629 
                 1400.7 
                 (M − H)− 
               
               
                 705 
                 SSC-TFA-07 
                 1.548 
                 1306.7 
                 (M + H)+ 
               
               
                 706 
                 SSC-FA-03 
                 1.911 
                 1489.6 
                 (M − H)− 
               
               
                 707 
                 SSC-TFA-07 
                 1.483 
                 1302.7 
                 (M + H)+ 
               
               
                 708 
                 SSC-TFA-07 
                 1.520 
                 1304.7 
                 (M + H)+ 
               
               
                 709 
                 SSC-TFA-07 
                 1.531 
                 1439.7 
                 (M + H)+ 
               
               
                 710 
                 SSC-TFA-07 
                 1.411 
                 1420.7 
                 (M + H)+ 
               
               
                 711 
                 SSC-AF-00 
                 2.189 
                 1466.0 
                 (M − H)− 
               
               
                 712 
                 SSC-TFA-07 
                 1.493 
                 1387.7 
                 (M + H)+ 
               
               
                 713 
                 SSC-A-FA-02 
                 6.597 
                 1408.6 
                 (M + H)+ 
               
               
                 714 
                 SSC-TFA-07 
                 1.375 
                 1262.6 
                 (M + H)+ 
               
               
                 715 
                 SSC-AF-00 
                 2.073 
                 1355.6 
                 (M − H)− 
               
               
                 716 
                 SSC-FA-03 
                 1.964 
                 1421.8 
                 (M − H)− 
               
               
                 717 
                 SSC-AF-00 
                 2.137 
                 1404.9 
                 (M − H)− 
               
               
                 718 
                 SSC-FA-03 
                 1.995 
                 1455.5 
                 (M − H)− 
               
               
                 719 
                 SSC-A-AF-01 
                 8.037 
                 1558.9 
                 (M − H)− 
               
               
                 720 
                 SSC-FA-03 
                 1.865 
                 1340.7 
                 (M − H)− 
               
               
                 721 
                 SSC-FA-03 
                 1.785 
                 1451.9 
                 (M − H)− 
               
               
                 722 
                 SSC-FA-03 
                 2.163 
                 1454.0 
                 (M − H)− 
               
               
                 723 
                 SSC-TFA-07 
                 1.544 
                 1330.7 
                 (M + H)+ 
               
               
                 724 
                 SSC-A-FA-02 
                 6.811 
                 1424.7 
                 (M + H)+ 
               
               
                 725 
                 SSC-AF-00 
                 2.211 
                 1500.0 
                 (M − H)− 
               
               
                 726 
                 SSC-A-FA-01 
                 5.923 
                 1437.9 
                 (M − H)− 
               
               
                 727 
                 SSC-AF-00 
                 2.275 
                 1557.1 
                 (M − H)− 
               
               
                 728 
                 SSC-FA-03 
                 2.157 
                 1453.9 
                 (M − H)− 
               
               
                 729 
                 SSC-AF-00 
                 2.211 
                 1437.8 
                 (M − H)− 
               
               
                 730 
                 SSC-FA-03 
                 2.199 
                 1469.9 
                 (M − H)− 
               
               
                 731 
                 SSC-A-AF-02 
                 8.049 
                 1452.7 
                 (M + H)+ 
               
               
                 732 
                 SSC-FA-03 
                 1.920 
                 1455.7 
                 (M − H)− 
               
               
                 733 
                 SSC-TFA-07 
                 1.579 
                 1439.6 
                 (M + H)+ 
               
               
                 734 
                 SSC-AF-00 
                 2.152 
                 1464.0 
                 (M − H)− 
               
               
                 735 
                 SSC-AF-00 
                 2.059 
                 1427.7 
                 (M − H)− 
               
               
                 736 
                 SSC-FA-03 
                 1.765 
                 1347.5 
                 (M + H)+ 
               
               
                 737 
                 SSC-AF-00 
                 2.281 
                 1442.0 
                 (M − H)− 
               
               
                 738 
                 SSC-A-FA-02 
                 6.660 
                 1368.7 
                 (M + H)+ 
               
               
                 739 
                 SSC-TFA-07 
                 1.388 
                 1387.8 
                 (M + H)+ 
               
               
                 740 
                 SSC-TFA-07 
                 1.484 
                 1322.6 
                 (M + H)+ 
               
               
                 741 
                 SSC-AF-00 
                 2.191 
                 1414.0 
                 (M − H)− 
               
               
                 742 
                 SSC-TFA-07 
                 1.441 
                 1334.7 
                 (M + H)+ 
               
               
                 743 
                 SSC-A-FA-02 
                 6.651 
                 1461.1 
                 (M − H)− 
               
               
                 744 
                 SSC-FA-03 
                 1.813 
                 1416.0 
                 (M − H)− 
               
               
                 745 
                 SSC-AF-00 
                 2.161 
                 1409.5 
                 (M − H)− 
               
               
                 746 
                 SSC-AF-00 
                 2.205 
                 1286.9 
                 (M − H)− 
               
               
                 747 
                 SSC-TFA-07 
                 1.577 
                 1330.6 
                 (M + H)+ 
               
               
                 748 
                 SSC-FA-03 
                 1.943 
                 1427.7 
                 (M − H)− 
               
               
                 749 
                 SSC-FA-03 
                 1.884 
                 1360.5 
                 (M − H)− 
               
               
                 750 
                 SSC-A-FA-02 
                 6.584 
                 1428.5 
                 (M + H)+ 
               
               
                 751 
                 SSC-TFA-07 
                 1.404 
                 1306.7 
                 (M + H)+ 
               
               
                 752 
                 SSC-TFA-07 
                 1.501 
                 1419.6 
                 (M + H)+ 
               
               
                 753 
                 SSC-FA-03 
                 1.968 
                 1348.5 
                 (M − H)− 
               
               
                 754 
                 SSC-AF-00 
                 2.191 
                 1511.9 
                 (M − H)− 
               
               
                 755 
                 SSC-FA-03 
                 1.937 
                 1453.8 
                 (M − H)− 
               
               
                 756 
                 SSC-AF-00 
                 2.179 
                 1427.9 
                 (M − H)− 
               
               
                 757 
                 SSC-FA-03 
                 1.751 
                 1517.0 
                 (M − H)− 
               
               
                 758 
                 SSC-TFA-07 
                 1.361 
                 1357.6 
                 (M + H)+ 
               
               
                 759 
                 SSC-AF-00 
                 2.140 
                 1442.0 
                 (M − H)− 
               
               
                 760 
                 SSC-AF-00 
                 2.179 
                 1399.9 
                 (M − H)− 
               
               
                 761 
                 SSC-A-FA-01 
                 6.021 
                 1520.7 
                 (M + H)+ 
               
               
                 762 
                 SSC-TFA-07 
                 1.592 
                 1429.8 
                 (M + H)+ 
               
               
                 764 
                 SSC-TFA-07 
                 1.415 
                 1322.9 
                 (M + H)+ 
               
               
                 765 
                 SSC-AF-00 
                 2.147 
                 1441.6 
                 (M − H)− 
               
               
                 766 
                 SSC-FA-03 
                 1.865 
                 1421.6 
                 (M − H)− 
               
               
                 767 
                 SSC-TFA-07 
                 1.375 
                 1309.7 
                 (M + H)+ 
               
               
                 768 
                 SSC-A-AF-01 
                 7.712 
                 1423.8 
                 (M − H)− 
               
               
                 769 
                 SSC-TFA-07 
                 1.409 
                 1397.7 
                 (M + H)+ 
               
               
                 770 
                 SSC-FA-03 
                 1.877 
                 1548.9 
                 (M + H)+ 
               
               
                 771 
                 SSC-TFA-07 
                 1.473 
                 1314.7 
                 (M + H)+ 
               
               
                 772 
                 SSC-TFA-07 
                 1.515 
                 1346.8 
                 (M + H)+ 
               
               
                 773 
                 SSC-AF-00 
                 2.159 
                 1260.9 
                 (M − H)− 
               
               
                 774 
                 SSC-FA-03 
                 1.872 
                 1467.7 
                 (M − H)− 
               
               
                 775 
                 SSC-A-FA-02 
                 6.701 
                 1420.7 
                 (M − H)− 
               
               
                 776 
                 SSC-FA-03 
                 1.868 
                 1314.9 
                 (M − H)− 
               
               
                 777 
                 SSC-A-FA-01 
                 6.740 
                 1491.9 
                 (M + H)+ 
               
               
                 778 
                 SSC-FA-03 
                 2.020 
                 1425.8 
                 (M − H)− 
               
               
                 779 
                 SSC-TFA-07 
                 1.401 
                 1421.8 
                 (M + H)+ 
               
               
                 780 
                 SSC-A-FA-01 
                 5.719 
                 1638.9 
                 (M + H)+ 
               
               
                 781 
                 SSC-FA-03 
                 1.888 
                 1501.6 
                 (M − H)− 
               
               
                 782 
                 SSC-TFA-07 
                 1.435 
                 1352.6 
                 (M + H)+ 
               
               
                 783 
                 SSC-FA-03 
                 2.005 
                 1505.6 
                 (M − H)− 
               
               
                 784 
                 SSC-FA-03 
                 1.775 
                 1395.8 
                 (M − H)− 
               
               
                 785 
                 SSC-A-FA-02 
                 6.371 
                 1464.6 
                 (M + H)+ 
               
               
                 786 
                 SSC-AF-00 
                 2.220 
                 1531.0 
                 (M − H)− 
               
               
                 787 
                 SSC-TFA-07 
                 1.513 
                 1413.7 
                 (M + H)+ 
               
               
                 788 
                 SSC-TFA-07 
                 1.368 
                 1260.7 
                 (M + H)+ 
               
               
                 789 
                 SSC-FA-03 
                 2.068 
                 1515.9 
                 (M − H)− 
               
               
                 790 
                 SSC-FA-03 
                 1.823 
                 1426.0 
                 (M − H)− 
               
               
                 791 
                 SSC-FA-03 
                 1.924 
                 1537.4 
                 (M + H)+ 
               
               
                 792 
                 SSC-AF-00 
                 2.161 
                 1429.9 
                 (M − H)− 
               
               
                 793 
                 SSC-A-FA-01 
                 5.032 
                 1456.7 
                 (M + H)+ 
               
               
                 794 
                 SSC-FA-03 
                 2.153 
                 1483.9 
                 (M − H)− 
               
               
                 795 
                 SSC-FA-03 
                 1.815 
                 1324.5 
                 (M − H)− 
               
               
                 796 
                 SSC-FA-03 
                 2.139 
                 1520.1 
                 (M − H)− 
               
               
                 797 
                 SSC-TFA-07 
                 1.459 
                 1320.7 
                 (M + H)+ 
               
               
                 798 
                 SSC-FA-03 
                 2.189 
                 1370.6 
                 (M − H)− 
               
               
                 799 
                 SSC-AF-00 
                 2.109 
                 1397.8 
                 (M − H)− 
               
               
                 800 
                 SSC-TFA-07 
                 1.456 
                 1320.8 
                 (M + H)+ 
               
               
                 801 
                 SSC-TFA-07 
                 1.643 
                 1346.7 
                 (M + H)+ 
               
               
                 802 
                 SSC-TFA-07 
                 1.379 
                 1266.6 
                 (M + H)+ 
               
               
                 803 
                 SSC-AF-00 
                 2.211 
                 1468.0 
                 (M − H)− 
               
               
                 804 
                 SSC-TFA-07 
                 1.395 
                 1371.7 
                 (M + H)+ 
               
               
                 805 
                 SSC-FA-03 
                 1.817 
                 1442.8 
                 (M − H)− 
               
               
                 806 
                 SSC-A-FA-01 
                 5.865 
                 1439.9 
                 (M + H)+ 
               
               
                 807 
                 SSC-AF-00 
                 2.167 
                 1412.0 
                 (M − H)− 
               
               
                 808 
                 SSC-TFA-07 
                 1.368 
                 1391.8 
                 (M + H)+ 
               
               
                 809 
                 SSC-AF-00 
                 2.281 
                 1483.8 
                 (M − H)− 
               
               
                 810 
                 SSC-AF-00 
                 2.160 
                 1385.5 
                 (M − H)− 
               
               
                 811 
                 SSC-TFA-07 
                 1.460 
                 1288.7 
                 (M + H)+ 
               
               
                 812 
                 SSC-AF-00 
                 2.272 
                 1514.1 
                 (M − H)− 
               
               
                 813 
                 SSC-FA-03 
                 2.088 
                 1571.7 
                 (M − H)− 
               
               
                 814 
                 SSC-AF-00 
                 2.091 
                 1459.7 
                 (M − H)− 
               
               
                 815 
                 SSC-TFA-07 
                 1.455 
                 1288.7 
                 (M + H)+ 
               
               
                 816 
                 SSC-A-FA-02 
                 6.792 
                 1476.6 
                 (M + H)+ 
               
               
                 817 
                 SSC-A-FA-01 
                 4.897 
                 1524.7 
                 (M + H)+ 
               
               
                 818 
                 SSC-AF-00 
                 2.135 
                 1528.9 
                 (M − H)− 
               
               
                 819 
                 SSC-AF-00 
                 2.233 
                 1587.7 
                 (M − H)− 
               
               
                 820 
                 SSC-AF-00 
                 2.207 
                 1441.8 
                 (M − H)− 
               
               
                 821 
                 SSC-FA-03 
                 1.945 
                 1439.9 
                 (M − H)− 
               
               
                 822 
                 SSC-AF-00 
                 2.152 
                 1445.9 
                 (M − H)− 
               
               
                 823 
                 SSC-FA-03 
                 1.961 
                 1423.8 
                 (M − H)− 
               
               
                 824 
                 SSC-TFA-07 
                 1.455 
                 1290.6 
                 (M + H)+ 
               
               
                 825 
                 SSC-FA-03 
                 1.939 
                 1363.6 
                 (M − H)− 
               
               
                 826 
                 SSC-AF-00 
                 2.136 
                 1494.9 
                 (M − H)− 
               
               
                 827 
                 SSC-AF-00 
                 2.049 
                 1401.6 
                 (M − H)− 
               
               
                 828 
                 SSC-A-AF-01 
                 7.365 
                 1355.6 
                 (M + H)+ 
               
               
                 829 
                 SSC-FA-03 
                 1.747 
                 1367.9 
                 (M − H)− 
               
               
                 830 
                 SSC-AF-00 
                 2.133 
                 1298.6 
                 (M − H)− 
               
               
                 831 
                 SSC-FA-03 
                 1.875 
                 1286.5 
                 (M − H)− 
               
               
                 832 
                 SSC-TFA-07 
                 1.451 
                 1278.7 
                 (M + H)+ 
               
               
                 833 
                 SSC-A-FA-02 
                 6.701 
                 1440.7 
                 (M − H)− 
               
               
                 834 
                 SSC-FA-03 
                 2.081 
                 1312.9 
                 (M − H)− 
               
               
                 835 
                 SSC-FA-03 
                 1.935 
                 1439.8 
                 (M − H)− 
               
               
                 836 
                 SSC-FA-03 
                 1.787 
                 1413.7 
                 (M − H)− 
               
               
                 837 
                 SSC-TFA-07 
                 1.477 
                 1290.6 
                 (M + H)+ 
               
               
                 838 
                 SSC-FA-03 
                 2.008 
                 1505.6 
                 (M − H)− 
               
               
                 839 
                 SSC-AF-00 
                 2.165 
                 1274.8 
                 (M + H)+ 
               
               
                 840 
                 SSC-A-FA-01 
                 5.016 
                 1394.0 
                 (M − H)− 
               
               
                 841 
                 SSC-TFA-07 
                 1.419 
                 1317.7 
                 (M + H)+ 
               
               
                 842 
                 SSC-TFA-07 
                 1.396 
                 1250.7 
                 (M + H)+ 
               
               
                 843 
                 SSC-TFA-07 
                 1.555 
                 1328.9 
                 (M + H)+ 
               
               
                 844 
                 SSC-AF-00 
                 2.105 
                 1272.7 
                 (M − H)− 
               
               
                 845 
                 SSC-TFA-07 
                 1.497 
                 1316.7 
                 (M + H)+ 
               
               
                 847 
                 SSC-TFA-07 
                 1.519 
                 1312.9 
                 (M + H)+ 
               
               
                 848 
                 SSC-FA-03 
                 2.136 
                 1456.0 
                 (M − H)− 
               
               
                 849 
                 SSC-FA-03 
                 2.104 
                 1466.1 
                 (M − H)− 
               
               
                 850 
                 SSC-FA-03 
                 1.809 
                 1401.9 
                 (M − H)− 
               
               
                 851 
                 SSC-TFA-07 
                 1.501 
                 1332.6 
                 (M + H)+ 
               
               
                 852 
                 SSC-TFA-07 
                 1.645 
                 1374.7 
                 (M + H)+ 
               
               
                 853 
                 SSC-AF-00 
                 2.077 
                 1415.7 
                 (M − H)− 
               
               
                 854 
                 SSC-FA-03 
                 2.063 
                 1475.8 
                 (M − H)− 
               
               
                 855 
                 SSC-FA-03 
                 2.113 
                 1515.6 
                 (M + H)+ 
               
               
                 856 
                 SSC-FA-03 
                 1.736 
                 1438.5 
                 (M − H)− 
               
               
                 857 
                 SSC-TFA-07 
                 1.469 
                 1302.7 
                 (M + H)+ 
               
               
                 858 
                 SSC-TFA-07 
                 1.527 
                 1376.8 
                 (M + H)+ 
               
               
                 859 
                 SSC-AF-00 
                 2.165 
                 1326.6 
                 (M − H)− 
               
               
                 860 
                 SSC-AF-00 
                 2.033 
                 1299.6 
                 (M − H)− 
               
               
                 861 
                 SSC-AF-00 
                 2.169 
                 1451.7 
                 (M − H)− 
               
               
                 862 
                 SSC-FA-03 
                 1.715 
                 1373.5 
                 (M − H)− 
               
               
                 863 
                 SSC-A-FA-01 
                 6.205 
                 1444.7 
                 (M + H)+ 
               
               
                 864 
                 SSC-TFA-07 
                 1.560 
                 1348.7 
                 (M + H)+ 
               
               
                 865 
                 SSC-AA-20 
                 2.064 
                 1292.7 
                 (M + H)+ 
               
               
                 866 
                 SSC-A-AF-01 
                 7.561 
                 1421.8 
                 (M − H)− 
               
               
                 867 
                 SSC-TFA-07 
                 1.401 
                 1420.7 
                 (M + H)+ 
               
               
                 868 
                 SSC-FA-03 
                 1.880 
                 1410.1 
                 (M − H)− 
               
               
                 869 
                 SSC-A-FA-02 
                 6.093 
                 1348.6 
                 (M + H)+ 
               
               
                 870 
                 SSC-TFA-07 
                 1.439 
                 1342.8 
                 (M + H)+ 
               
               
                 871 
                 SSC-AF-00 
                 2.053 
                 1410.0 
                 (M − H)− 
               
               
                 872 
                 SSC-FA-03 
                 2.127 
                 1472.0 
                 (M − H)− 
               
               
                 873 
                 SSC-AF-00 
                 2.195 
                 1340.9 
                 (M − H)− 
               
               
                 874 
                 SSC-TFA-07 
                 1.431 
                 1302.7 
                 (M + H)+ 
               
               
                 875 
                 SSC-TFA-07 
                 1.425 
                 1415.7 
                 (M + H)+ 
               
               
                 876 
                 SSC-FA-03 
                 2.055 
                 1517.7 
                 (M − H)− 
               
               
                 877 
                 SSC-AF-00 
                 2.195 
                 1425.9 
                 (M − H)− 
               
               
                 878 
                 SSC-TFA-07 
                 1.443 
                 1419.7 
                 (M + H)+ 
               
               
                 879 
                 SSC-TFA-07 
                 1.400 
                 1274.7 
                 (M + H)+ 
               
               
                 880 
                 SSC-FA-03 
                 1.909 
                 1413.8 
                 (M − H)− 
               
               
                 881 
                 SSC-FA-03 
                 1.924 
                 1493.8 
                 (M − H)− 
               
               
                 882 
                 SSC-FA-03 
                 1.817 
                 1487.9 
                 (M − H)− 
               
               
                 883 
                 SSC-AF-00 
                 2.151 
                 1292.8 
                 (M + H)+ 
               
               
                 884 
                 SSC-AA-20 
                 2.132 
                 1449.6 
                 (M + H)+ 
               
               
                 885 
                 SSC-AF-00 
                 2.172 
                 1427.8 
                 (M − H)− 
               
               
                 886 
                 SSC-TFA-07 
                 1.627 
                 1334.7 
                 (M + H)+ 
               
               
                 887 
                 SSC-AF-00 
                 2.223 
                 1535.0 
                 (M − H)− 
               
               
                 888 
                 SSC-TFA-07 
                 1.389 
                 1323.7 
                 (M + H)+ 
               
               
                 889 
                 SSC-TFA-07 
                 1.360 
                 1458.8 
                 (M + H)+ 
               
               
                 890 
                 SSC-AF-00 
                 2.153 
                 1439.9 
                 (M − H)− 
               
               
                 891 
                 SSC-A-FA-02 
                 6.420 
                 1338.6 
                 (M − H)− 
               
               
                 892 
                 SSC-TFA-07 
                 1.567 
                 1320.8 
                 (M + H)+ 
               
               
                 893 
                 SSC-TFA-07 
                 1.468 
                 1333.8 
                 (M + H)+ 
               
               
                 894 
                 SSC-AF-00 
                 2.211 
                 1495.7 
                 (M − H)− 
               
               
                 895 
                 SSC-AF-00 
                 2.187 
                 1445.8 
                 (M − H)− 
               
               
                 896 
                 SSC-A-AF-01 
                 7.573 
                 1422.0 
                 (M − H)− 
               
               
                 897 
                 SSC-AF-00 
                 2.173 
                 1346.7 
                 (M + H)+ 
               
               
                 898 
                 SSC-A-FA-02 
                 6.677 
                 1418.7 
                 (M − H)− 
               
               
                 899 
                 SSC-A-FA-01 
                 6.756 
                 1439.9 
                 (M − H)− 
               
               
                 900 
                 SSC-A-AF-01 
                 7.679 
                 1456.7 
                 (M + H)+ 
               
               
                 901 
                 SSC-TFA-07 
                 1.540 
                 1316.6 
                 (M + H)+ 
               
               
                 902 
                 SSC-TFA-07 
                 1.388 
                 1272.7 
                 (M + H)+ 
               
               
                 903 
                 SSC-FA-03 
                 1.729 
                 1315.6 
                 (M − H)− 
               
               
                 904 
                 SSC-TFA-07 
                 1.551 
                 1318.7 
                 (M + H)+ 
               
               
                 905 
                 SSC-TFA-07 
                 1.512 
                 1304.8 
                 (M + H)+ 
               
               
                 906 
                 SSC-FA-03 
                 1.861 
                 1427.7 
                 (M − H)− 
               
               
                 907 
                 SSC-A-AF-01 
                 7.649 
                 1408.6 
                 (M + H)+ 
               
               
                 908 
                 SSC-FA-03 
                 2.101 
                 1489.8 
                 (M − H)− 
               
               
                 909 
                 SSC-AF-00 
                 2.109 
                 1298.6 
                 (M − H)− 
               
               
                 910 
                 SSC-AF-00 
                 2.200 
                 1532.7 
                 (M − H)− 
               
               
                 911 
                 SSC-TFA-07 
                 1.551 
                 1413.7 
                 (M + H)+ 
               
               
                 912 
                 SSC-FA-03 
                 2.017 
                 1487.5 
                 (M + H)+ 
               
               
                 913 
                 SSC-TFA-07 
                 1.427 
                 1334.6 
                 (M + H)+ 
               
               
                 914 
                 SSC-FA-03 
                 1.588 
                 1476.8 
                 (M − H)− 
               
               
                 915 
                 SSC-AF-00 
                 2.051 
                 1369.7 
                 (M − H)− 
               
               
                 916 
                 SSC-TFA-07 
                 1.417 
                 1345.8 
                 (M + H)+ 
               
               
                 917 
                 SSC-AF-00 
                 2.200 
                 1399.8 
                 (M − H)− 
               
               
                 918 
                 SSC-AF-00 
                 2.075 
                 1394.1 
                 (M − H)− 
               
               
                 919 
                 SSC-AF-00 
                 2.048 
                 1281.8 
                 (M − H)− 
               
               
                 920 
                 SSC-AF-00 
                 2.193 
                 1494.1 
                 (M − H)− 
               
               
                 921 
                 SSC-A-FA-01 
                 5.544 
                 1435.8 
                 (M − H)− 
               
               
                 922 
                 SSC-AF-00 
                 2.156 
                 1324.7 
                 (M − H)− 
               
               
                 923 
                 SSC-TFA-07 
                 1.429 
                 1300.7 
                 (M + H)+ 
               
               
                 924 
                 SSC-TFA-07 
                 1.536 
                 1316.6 
                 (M + H)+ 
               
               
                 925 
                 SSC-TFA-07 
                 1.409 
                 1395.7 
                 (M + H)+ 
               
               
                 926 
                 SSC-FA-03 
                 1.856 
                 1453.9 
                 (M − H)− 
               
               
                 927 
                 SSC-TFA-07 
                 1.493 
                 1336.9 
                 (M + H)+ 
               
               
                 928 
                 SSC-A-FA-02 
                 6.937 
                 1421.0 
                 (M − H)− 
               
               
                 929 
                 SSC-FA-03 
                 1.856 
                 1387.8 
                 (M − H)− 
               
               
                 930 
                 SSC-AF-00 
                 2.061 
                 1262.5 
                 (M + H)+ 
               
               
                 931 
                 SSC-FA-03 
                 1.951 
                 1473.9 
                 (M − H)− 
               
               
                 932 
                 SSC-A-FA-02 
                 6.813 
                 1464.7 
                 (M + H)+ 
               
               
                 933 
                 SSC-FA-03 
                 1.905 
                 1337.0 
                 (M − H)− 
               
               
                 934 
                 SSC-FA-03 
                 2.075 
                 1537.7 
                 (M − H)− 
               
               
                 935 
                 SSC-TFA-07 
                 1.415 
                 1420.6 
                 (M + H)+ 
               
               
                 936 
                 SSC-AF-00 
                 2.148 
                 1397.5 
                 (M − H)− 
               
               
                 937 
                 SSC-TFA-07 
                 1.540 
                 1316.6 
                 (M + H)+ 
               
               
                 938 
                 SSC-FA-03 
                 1.701 
                 1446.0 
                 (M − H)− 
               
               
                 939 
                 SSC-FA-03 
                 1.949 
                 1387.8 
                 (M − H)− 
               
               
                 940 
                 SSC-AF-00 
                 2.347 
                 1514.1 
                 (M − H)− 
               
               
                 941 
                 SSC-FA-03 
                 1.963 
                 1441.8 
                 (M − H)− 
               
               
                 942 
                 SSC-FA-03 
                 1.633 
                 1474.8 
                 (M − H)− 
               
               
                 943 
                 SSC-FA-03 
                 1.785 
                 1469.5 
                 (M − H)− 
               
               
                 944 
                 SSC-TFA-07 
                 1.467 
                 1292.7 
                 (M + H)+ 
               
               
                 945 
                 SSC-AF-00 
                 2.167 
                 1439.7 
                 (M − H)− 
               
               
                 946 
                 SSC-AF-00 
                 2.124 
                 1407.9 
                 (M − H)− 
               
               
                 947 
                 SSC-A-FA-02 
                 6.931 
                 1414.7 
                 (M + H)+ 
               
               
                 948 
                 SSC-AF-00 
                 2.152 
                 1397.9 
                 (M − H)− 
               
               
                 949 
                 SSC-A-FA-02 
                 6.668 
                 1454.5 
                 (M + H)+ 
               
               
                 950 
                 SSC-FA-03 
                 2.104 
                 1552.9 
                 (M − H)− 
               
               
                 951 
                 SSC-A-FA-02 
                 6.720 
                 1408.7 
                 (M − H)− 
               
               
                 952 
                 SSC-TFA-07 
                 1.472 
                 1300.7 
                 (M + H)+ 
               
               
                 953 
                 SSC-AF-00 
                 2.175 
                 1359.6 
                 (M + H)+ 
               
               
                 954 
                 SSC-FA-03 
                 1.868 
                 1329.6 
                 (M − H)− 
               
               
                 955 
                 SSC-TFA-07 
                 1.465 
                 1419.7 
                 (M + H)+ 
               
               
                 956 
                 SSC-AF-00 
                 2.105 
                 1306.7 
                 (M + H)+ 
               
               
                 957 
                 SSC-FA-03 
                 1.780 
                 1381.9 
                 (M − H)− 
               
               
                 958 
                 SSC-AF-00 
                 2.161 
                 1471.8 
                 (M − H)− 
               
               
                 959 
                 SSC-FA-03 
                 2.021 
                 1438.0 
                 (M − H)− 
               
               
                 960 
                 SSC-AF-00 
                 2.283 
                 1529.7 
                 (M + H)+ 
               
               
                 961 
                 SSC-AF-00 
                 2.143 
                 1484.6 
                 (M − H)− 
               
               
                 962 
                 SSC-A-FA-02 
                 6.436 
                 1352.6 
                 (M + H)+ 
               
               
                 963 
                 SSC-FA-03 
                 1.999 
                 1455.7 
                 (M − H)− 
               
               
                 964 
                 SSC-AF-00 
                 2.195 
                 1409.5 
                 (M − H)− 
               
               
                 965 
                 SSC-A-FA-01 
                 5.088 
                 1422.0 
                 (M − H)− 
               
               
                 966 
                 SSC-TFA-07 
                 1.544 
                 1328.7 
                 (M + H)+ 
               
               
                 967 
                 SSC-TFA-07 
                 1.457 
                 1278.8 
                 (M + H)+ 
               
               
                 968 
                 SSC-TFA-07 
                 1.565 
                 1427.7 
                 (M + H)+ 
               
               
                 969 
                 SSC-TFA-07 
                 1.528 
                 1389.8 
                 (M + H)+ 
               
               
                 970 
                 SSC-TFA-07 
                 1.636 
                 1332.7 
                 (M + H)+ 
               
               
                 971 
                 SSC-FA-03 
                 1.881 
                 1470.4 
                 (M − H)− 
               
               
                 972 
                 SSC-AF-00 
                 2.183 
                 1362.9 
                 (M − H)− 
               
               
                 973 
                 SSC-FA-03 
                 1.899 
                 1479.6 
                 (M − H)− 
               
               
                 974 
                 SSC-FA-03 
                 1.731 
                 1429.8 
                 (M − H)− 
               
               
                 975 
                 SSC-TFA-07 
                 1.372 
                 1309.5 
                 (M + H)+ 
               
               
                 976 
                 SSC-FA-03 
                 1.711 
                 1295.7 
                 (M − H)− 
               
               
                 977 
                 SSC-FA-03 
                 1.923 
                 1423.6 
                 (M − H)− 
               
               
                 978 
                 SSC-TFA-07 
                 1.419 
                 1294.8 
                 (M + H)+ 
               
               
                 979 
                 SSC-AF-00 
                 2.108 
                 1274.4 
                 (M − H)− 
               
               
                 980 
                 SSC-TFA-07 
                 1.449 
                 1385.7 
                 (M + H)+ 
               
               
                 981 
                 SSC-FA-03 
                 1.812 
                 1529.7 
                 (M − H)− 
               
               
                 982 
                 SSC-FA-03 
                 1.784 
                 1466.7 
                 (M − H)− 
               
               
                 983 
                 SSC-FA-03 
                 2.175 
                 1480.0 
                 (M − H)− 
               
               
                 984 
                 SSC-A-FA-01 
                 6.952 
                 1588.8 
                 (M + H)+ 
               
               
                 985 
                 SSC-TFA-07 
                 1.441 
                 1276.7 
                 (M + H)+ 
               
               
                 986 
                 SSC-AF-00 
                 2.223 
                 1440.0 
                 (M − H)− 
               
               
                 987 
                 SSC-FA-03 
                 1.745 
                 1398.1 
                 (M − H)− 
               
               
                 988 
                 SSC-TFA-07 
                 1.581 
                 1453.8 
                 (M + H)+ 
               
               
                 989 
                 SSC-TFA-07 
                 1.329 
                 1391.8 
                 (M + H)+ 
               
               
                 990 
                 SSC-FA-03 
                 1.817 
                 1326.4 
                 (M + H)+ 
               
               
                 991 
                 SSC-TFA-07 
                 1.584 
                 1344.7 
                 (M + H)+ 
               
               
                 992 
                 SSC-TFA-07 
                 1.705 
                 1376.7 
                 (M + H)+ 
               
               
                 993 
                 SSC-AF-00 
                 2.117 
                 1359.9 
                 (M − H)− 
               
               
                 994 
                 SSC-TFA-07 
                 1.476 
                 1368.6 
                 (M + H)+ 
               
               
                 995 
                 SSC-AF-00 
                 2.184 
                 1425.6 
                 (M − H)− 
               
               
                 996 
                 SSC-TFA-07 
                 1.520 
                 1340.7 
                 (M + H)+ 
               
               
                 997 
                 SSC-FA-03 
                 2.023 
                 1521.5 
                 (M − H)− 
               
               
                 998 
                 SSC-TFA-07 
                 1.653 
                 1556.9 
                 (M + H)+ 
               
               
                 999 
                 SSC-FA-03 
                 1.841 
                 1383.6 
                 (M − H)− 
               
               
                 1000 
                 SSC-AF-00 
                 2.157 
                 1489.8 
                 (M − H)− 
               
               
                 1001 
                 SSC-FA-03 
                 1.791 
                 1475.9 
                 (M − H)− 
               
               
                 1002 
                 SSC-FA-03 
                 1.800 
                 1439.6 
                 (M − H)− 
               
               
                 1003 
                 SSC-A-FA-02 
                 6.353 
                 1416.6 
                 (M + H)+ 
               
               
                 1004 
                 SSC-FA-03 
                 1.813 
                 1292.9 
                 (M − H)− 
               
               
                 1005 
                 SSC-FA-03 
                 2.143 
                 1455.9 
                 (M − H)− 
               
               
                 1006 
                 SSC-A-FA-02 
                 6.283 
                 1446.6 
                 (M − H)− 
               
               
                 1007 
                 SSC-AF-00 
                 2.279 
                 1348.6 
                 (M − H)− 
               
               
                 1008 
                 SSC-AF-00 
                 2.137 
                 1444.0 
                 (M − H)− 
               
               
                 1009 
                 SSC-FA-03 
                 2.075 
                 1509.8 
                 (M − H)− 
               
               
                 1010 
                 SSC-FA-03 
                 1.879 
                 1399.8 
                 (M − H)− 
               
               
                 1011 
                 SSC-AF-00 
                 2.057 
                 1307.9 
                 (M − H)− 
               
               
                 1012 
                 SSC-AF-00 
                 2.168 
                 1463.0 
                 (M − H)− 
               
               
                 1013 
                 SSC-TFA-07 
                 1.363 
                 1272.8 
                 (M + H)+ 
               
               
                 1014 
                 SSC-TFA-07 
                 1.541 
                 1348.6 
                 (M + H)+ 
               
               
                 1015 
                 SSC-AF-00 
                 2.183 
                 1481.9 
                 (M − H)− 
               
               
                 1016 
                 SSC-FA-03 
                 2.263 
                 1541.8 
                 (M − H)− 
               
               
                 1017 
                 SSC-FA-03 
                 1.724 
                 1391.9 
                 (M − H)− 
               
               
                 1018 
                 SSC-TFA-07 
                 1.432 
                 1344.6 
                 (M + H)+ 
               
               
                 1019 
                 SSC-TFA-07 
                 1.481 
                 1316.7 
                 (M + H)+ 
               
               
                 1020 
                 SSC-TFA-07 
                 1.491 
                 1302.7 
                 (M + H)+ 
               
               
                 1021 
                 SSC-AF-00 
                 2.156 
                 1328.7 
                 (M + H)+ 
               
               
                 1022 
                 SSC-AF-00 
                 2.220 
                 1454.0 
                 (M − H)− 
               
               
                 1023 
                 SSC-AF-00 
                 2.195 
                 1363.0 
                 (M − H)− 
               
               
                 1024 
                 SSC-AF-00 
                 2.075 
                 1368.0 
                 (M − H)− 
               
               
                 1025 
                 SSC-FA-03 
                 1.845 
                 1492.9 
                 (M − H)− 
               
               
                 1026 
                 SSC-FA-03 
                 2.020 
                 1443.8 
                 (M − H)− 
               
               
                 1027 
                 SSC-FA-03 
                 1.808 
                 1372.0 
                 (M − H)− 
               
               
                 1029 
                 SSC-AF-00 
                 2.129 
                 1412.1 
                 (M − H)− 
               
               
                 1030 
                 SSC-AF-00 
                 2.084 
                 1440.1 
                 (M − H)− 
               
               
                 1031 
                 SSC-TFA-07 
                 1.439 
                 1278.8 
                 (M + H)+ 
               
               
                 1032 
                 SSC-AF-00 
                 2.245 
                 1332.6 
                 (M + H)+ 
               
               
                 1033 
                 SSC-TFA-07 
                 1.604 
                 1332.7 
                 (M + H)+ 
               
               
                 1034 
                 SSC-FA-03 
                 1.741 
                 1371.9 
                 (M − H)− 
               
               
                 1035 
                 SSC-AF-00 
                 2.209 
                 1521.6 
                 (M − H)− 
               
               
                 1036 
                 SSC-AF-00 
                 2.179 
                 1423.9 
                 (M − H)− 
               
               
                 1037 
                 SSC-FA-03 
                 1.952 
                 1427.8 
                 (M − H)− 
               
               
                 1038 
                 SSC-TFA-07 
                 1.517 
                 1304.7 
                 (M + H)+ 
               
               
                 1039 
                 SSC-A-FA-01 
                 6.327 
                 1616.8 
                 (M + H)+ 
               
               
                 1040 
                 SSC-AF-00 
                 2.161 
                 1410.0 
                 (M − H)− 
               
               
                 1041 
                 SSC-FA-03 
                 1.801 
                 1401.9 
                 (M − H)− 
               
               
                 1042 
                 SSC-A-AF-01 
                 7.533 
                 1421.8 
                 (M − H)− 
               
               
                 1043 
                 SSC-AF-00 
                 2.117 
                 1317.8 
                 (M + H)+ 
               
               
                 1044 
                 SSC-AF-00 
                 2.231 
                 1537.6 
                 (M − H)− 
               
               
                 1045 
                 SSC-AF-00 
                 2.260 
                 1441.8 
                 (M − H)− 
               
               
                 1046 
                 SSC-FA-03 
                 1.916 
                 1326.9 
                 (M − H)− 
               
               
                 1047 
                 SSC-FA-03 
                 1.904 
                 1423.7 
                 (M − H)− 
               
               
                 1048 
                 SSC-TFA-07 
                 1.339 
                 1389.9 
                 (M + H)+ 
               
               
                 1049 
                 SSC-A-AF-02 
                 7.935 
                 1456.6 
                 (M + H)+ 
               
               
                 1050 
                 SSC-TFA-07 
                 1.536 
                 1316.7 
                 (M + H)+ 
               
               
                 1051 
                 SSC-TFA-07 
                 1.453 
                 1373.7 
                 (M + H)+ 
               
               
                 1052 
                 SSC-FA-03 
                 2.075 
                 1571.8 
                 (M − H)− 
               
               
                 1053 
                 SSC-FA-03 
                 2.221 
                 1542.0 
                 (M − H)− 
               
               
                 1054 
                 SSC-AF-00 
                 2.107 
                 1306.7 
                 (M + H)+ 
               
               
                 1055 
                 SSC-AF-00 
                 2.137 
                 1309.7 
                 (M − H)− 
               
               
                 1056 
                 SSC-AF-00 
                 2.129 
                 1272.9 
                 (M − H)− 
               
               
                 1057 
                 SSC-FA-03 
                 1.869 
                 1479.9 
                 (M − H)− 
               
               
                 1058 
                 SSC-AF-00 
                 2.183 
                 1525.5 
                 (M − H)− 
               
               
                 1059 
                 SSC-A-FA-01 
                 5.319 
                 1419.7 
                 (M − H)− 
               
               
                 1060 
                 SSC-FA-03 
                 1.897 
                 1451.9 
                 (M − H)− 
               
               
                 1061 
                 SSC-TFA-07 
                 1.459 
                 1427.7 
                 (M + H)+ 
               
               
                 1062 
                 SSC-A-AF-01 
                 7.752 
                 1454.6 
                 (M + H)+ 
               
               
                 1063 
                 SSC-AF-00 
                 2.229 
                 1509.8 
                 (M − H)− 
               
               
                 1064 
                 SSC-AF-00 
                 2.169 
                 1411.9 
                 (M − H)− 
               
               
                 1065 
                 SSC-AF-00 
                 2.176 
                 1314.5 
                 (M − H)− 
               
               
                 1066 
                 SSC-FA-03 
                 1.765 
                 1258.5 
                 (M − H)− 
               
               
                 1067 
                 SSC-TFA-07 
                 1.364 
                 1270.8 
                 (M + H)+ 
               
               
                 1068 
                 SSC-TFA-07 
                 1.563 
                 1320.7 
                 (M + H)+ 
               
               
                 1069 
                 SSC-TFA-07 
                 1.473 
                 1334.6 
                 (M + H)+ 
               
               
                 1070 
                 SSC-A-AF-01 
                 7.624 
                 1425.9 
                 (M − H)− 
               
               
                 1071 
                 SSC-FA-03 
                 1.613 
                 1476.8 
                 (M − H)− 
               
               
                 1072 
                 SSC-AF-00 
                 2.125 
                 1401.7 
                 (M − H)− 
               
               
                 1073 
                 SSC-AF-00 
                 2.191 
                 1425.9 
                 (M − H)− 
               
               
                 1074 
                 SSC-A-FA-02 
                 6.265 
                 1402.6 
                 (M + H)+ 
               
               
                 1075 
                 SSC-AF-00 
                 2.137 
                 1316.9 
                 (M − H)− 
               
               
                 1076 
                 SSC-TFA-07 
                 1.536 
                 1308.7 
                 (M + H)+ 
               
               
                 1077 
                 SSC-FA-03 
                 1.847 
                 1310.5 
                 (M − H)− 
               
               
                 1078 
                 SSC-FA-03 
                 1.923 
                 1522.8 
                 (M − H)− 
               
               
                 1079 
                 SSC-TFA-07 
                 1.527 
                 1356.6 
                 (M + H)+ 
               
               
                 1080 
                 SSC-A-AF-01 
                 7.272 
                 1410.0 
                 (M − H)− 
               
               
                 1081 
                 SSC-FA-03 
                 1.516 
                 1492.6 
                 (M − H)− 
               
               
                 1082 
                 SSC-TFA-07 
                 1.555 
                 1328.7 
                 (M + H)+ 
               
               
                 1083 
                 SSC-FA-03 
                 1.875 
                 1306.9 
                 (M − H)− 
               
               
                 1084 
                 SSC-TFA-07 
                 1.411 
                 1306.7 
                 (M + H)+ 
               
               
                 1085 
                 SSC-TFA-07 
                 1.391 
                 1391.8 
                 (M + H)+ 
               
               
                 1086 
                 SSC-AA-20 
                 2.083 
                 1290.4 
                 (M − H)− 
               
               
                 1087 
                 SSC-FA-03 
                 1.739 
                 1518.9 
                 (M − H)− 
               
               
                 1088 
                 SSC-FA-03 
                 1.880 
                 1294.5 
                 (M − H)− 
               
               
                 1089 
                 SSC-AF-00 
                 2.185 
                 1468.0 
                 (M − H)− 
               
               
                 1090 
                 SSC-TFA-07 
                 1.355 
                 1228.8 
                 (M + H)+ 
               
               
                 1091 
                 SSC-FA-03 
                 1.860 
                 1422.1 
                 (M − H)− 
               
               
                 1092 
                 SSC-TFA-07 
                 1.373 
                 1455.7 
                 (M + H)+ 
               
               
                 1093 
                 SSC-FA-03 
                 2.097 
                 1457.8 
                 (M − H)− 
               
               
                 1094 
                 SSC-FA-03 
                 1.800 
                 1449.7 
                 (M − H)− 
               
               
                 1095 
                 SSC-TFA-07 
                 1.577 
                 1318.8 
                 (M + H)+ 
               
               
                 1096 
                 SSC-AF-00 
                 2.328 
                 1544.0 
                 (M + H)+ 
               
               
                 1097 
                 SSC-TFA-07 
                 1.429 
                 1254.8 
                 (M + H)+ 
               
               
                 1098 
                 SSC-AF-00 
                 2.060 
                 1398.0 
                 (M − H)− 
               
               
                 1099 
                 SSC-AF-00 
                 2.131 
                 1407.6 
                 (M − H)− 
               
               
                 1100 
                 SSC-FA-03 
                 1.883 
                 1486.0 
                 (M − H)− 
               
               
                 1101 
                 SSC-FA-03 
                 1.879 
                 1415.9 
                 (M − H)− 
               
               
                 1102 
                 SSC-TFA-07 
                 1.604 
                 1372.7 
                 (M + H)+ 
               
               
                 1103 
                 SSC-FA-03 
                 1.909 
                 1397.9 
                 (M − H)− 
               
               
                 1104 
                 SSC-A-AF-01 
                 7.524 
                 1480.6 
                 (M + H)+ 
               
               
                 1105 
                 SSC-TFA-07 
                 1.485 
                 1340.6 
                 (M + H)+ 
               
               
                 1106 
                 SSC-AF-00 
                 2.171 
                 1411.9 
                 (M − H)− 
               
               
                 1107 
                 SSC-TFA-07 
                 1.495 
                 1314.7 
                 (M + H)+ 
               
               
                 1108 
                 SSC-A-FA-01 
                 5.573 
                 1510.7 
                 (M + H)+ 
               
               
                 1109 
                 SSC-AF-00 
                 2.161 
                 1399.9 
                 (M − H)− 
               
               
                 1110 
                 SSC-TFA-07 
                 1.527 
                 1348.6 
                 (M + H)+ 
               
               
                 1111 
                 SSC-TFA-07 
                 1.424 
                 1262.7 
                 (M + H)+ 
               
               
                 1112 
                 SSC-AF-00 
                 2.157 
                 1454.1 
                 (M + H)+ 
               
               
                 1113 
                 SSC-AF-00 
                 2.301 
                 1481.8 
                 (M − H)− 
               
               
                 1114 
                 SSC-AF-00 
                 2.200 
                 1437.9 
                 (M − H)− 
               
               
                 1115 
                 SSC-AF-00 
                 2.293 
                 1485.8 
                 (M + H)+ 
               
               
                 1116 
                 SSC-FA-03 
                 1.749 
                 1515.8 
                 (M − H)− 
               
               
                 1117 
                 SSC-A-FA-01 
                 5.455 
                 1397.6 
                 (M + H)+ 
               
               
                 1118 
                 SSC-FA-03 
                 1.989 
                 1397.5 
                 (M − H)− 
               
               
                 1119 
                 SSC-TFA-07 
                 1.463 
                 1449.7 
                 (M + H)+ 
               
               
                 1120 
                 SSC-A-FA-01 
                 5.471 
                 1421.8 
                 (M − H)− 
               
               
                 1121 
                 SSC-FA-03 
                 1.825 
                 1383.6 
                 (M − H)− 
               
               
                 1122 
                 SSC-AF-00 
                 2.193 
                 1402.7 
                 (M − H)− 
               
               
                 1123 
                 SSC-FA-03 
                 1.929 
                 1490.0 
                 (M − H)− 
               
               
                 1124 
                 SSC-TFA-07 
                 1.453 
                 1373.7 
                 (M + H)+ 
               
               
                 1125 
                 SSC-AF-00 
                 2.144 
                 1407.9 
                 (M − H)− 
               
               
                 1126 
                 SSC-TFA-07 
                 1.539 
                 1340.6 
                 (M + H)+ 
               
               
                 1127 
                 SSC-FA-03 
                 1.940 
                 1524.0 
                 (M − H)− 
               
               
                 1128 
                 SSC-TFA-07 
                 1.529 
                 1413.7 
                 (M + H)+ 
               
               
                 1129 
                 SSC-FA-03 
                 2.043 
                 1565.5 
                 (M − H)− 
               
               
                 1130 
                 SSC-AF-00 
                 2.168 
                 1387.9 
                 (M − H)− 
               
               
                 1131 
                 SSC-A-AF-01 
                 7.592 
                 1395.7 
                 (M − H)− 
               
               
                 1132 
                 SSC-FA-03 
                 1.993 
                 1425.8 
                 (M − H)− 
               
               
                 1133 
                 SSC-AF-00 
                 2.157 
                 1346.7 
                 (M + H)+ 
               
               
                 1134 
                 SSC-AF-00 
                 2.240 
                 1452.0 
                 (M − H)− 
               
               
                 1135 
                 SSC-FA-03 
                 1.444 
                 1488.8 
                 (M − H)− 
               
               
                 1136 
                 SSC-FA-03 
                 1.953 
                 1483.9 
                 (M − H)− 
               
               
                 1137 
                 SSC-A-FA-01 
                 5.269 
                 1439.6 
                 (M − H)− 
               
               
                 1138 
                 SSC-FA-03 
                 2.125 
                 1427.9 
                 (M − H)− 
               
               
                 1139 
                 SSC-A-AF-01 
                 7.524 
                 1557.7 
                 (M − H)− 
               
               
                 1140 
                 SSC-A-FA-01 
                 4.973 
                 1427.7 
                 (M + H)+ 
               
               
                 1141 
                 SSC-A-FA-01 
                 5.353 
                 1419.7 
                 (M − H)− 
               
               
                 1142 
                 SSC-A-FA-01 
                 5.333 
                 1439.8 
                 (M − H)− 
               
               
                 1143 
                 SSC-A-FA-01 
                 5.688 
                 1470.1 
                 (M − H)− 
               
               
                 1144 
                 SSC-A-FA-01 
                 5.969 
                 1470.1 
                 (M − H)− 
               
               
                 1145 
                 SSC-A-AF-01 
                 7.457 
                 1437.8 
                 (M − H)− 
               
               
                 1146 
                 SSC-A-FA-01 
                 5.632 
                 1487.8 
                 (M − H)− 
               
               
                 1148 
                 SSC-A-AF-01 
                 7.523 
                 1433.8 
                 (M − H)− 
               
               
                 1149 
                 SSC-A-FA-01 
                 5.876 
                 1499.6 
                 (M + H)+ 
               
               
                 1150 
                 SSC-FA-03 
                 2.049 
                 1454.0 
                 (M − H)− 
               
               
                 1151 
                 SSC-A-FA-01 
                 5.496 
                 1517.8 
                 (M − H)− 
               
               
                 1152 
                 SSC-A-AF-01 
                 7.393 
                 1417.6 
                 (M − H)− 
               
               
                 1153 
                 SSC-FA-03 
                 1.961 
                 1336.5 
                 (M − H)− 
               
               
                 1154 
                 SSC-A-AF-01 
                 7.671 
                 1469.9 
                 (M − H)− 
               
               
                 1155 
                 SSC-AF-00 
                 2.105 
                 1513.4 
                 (M − H)− 
               
               
                 1156 
                 SSC-FA-03 
                 1.977 
                 1471.7 
                 (M + H)+ 
               
               
                 1157 
                 SSC-FA-03 
                 2.037 
                 1428.0 
                 (M − H)− 
               
               
                 1158 
                 SSC-A-AF-01 
                 7.832 
                 1467.9 
                 (M − H)− 
               
               
                 1159 
                 SSC-A-AF-01 
                 7.680 
                 1501.7 
                 (M − H)− 
               
               
                 1160 
                 SSC-A-FA-01 
                 5.996 
                 1450.0 
                 (M − H)− 
               
               
                 1161 
                 SSC-FA-03 
                 1.984 
                 1425.9 
                 (M − H)− 
               
               
                 1162 
                 SSC-A-FA-01 
                 5.751 
                 1458.1 
                 (M − H)− 
               
               
                 1163 
                 SSC-A-AF-01 
                 7.803 
                 1447.9 
                 (M − H)− 
               
               
                 1164 
                 SSC-A-AF-01 
                 7.359 
                 1382.0 
                 (M − H)− 
               
               
                 1165 
                 SSC-A-FA-01 
                 5.871 
                 1413.9 
                 (M − H)− 
               
               
                 1166 
                 SSC-A-FA-01 
                 5.811 
                 1450.0 
                 (M − H)− 
               
               
                 1167 
                 SSC-A-FA-01 
                 5.355 
                 1455.8 
                 (M − H)− 
               
               
                 1168 
                 SSC-FA-03 
                 1.980 
                 1457.9 
                 (M − H)− 
               
               
                 1169 
                 SSC-AF-00 
                 2.061 
                 1419.9 
                 (M − H)− 
               
               
                 1170 
                 SSC-A-FA-01 
                 5.619 
                 1414.0 
                 (M − H)− 
               
               
                 1171 
                 SSC-A-AF-01 
                 7.760 
                 1453.8 
                 (M − H)− 
               
               
                 1172 
                 SSC-FA-03 
                 2.005 
                 1413.7 
                 (M − H)− 
               
               
                 1173 
                 SSC-A-AF-01 
                 7.568 
                 1453.7 
                 (M + H)+ 
               
               
                 1174 
                 SSC-AF-00 
                 2.140 
                 1386.0 
                 (M − H)− 
               
               
                 1175 
                 SSC-A-AF-01 
                 7.673 
                 1504.0 
                 (M − H)− 
               
               
                 1176 
                 SSC-A-AF-01 
                 7.804 
                 1465.8 
                 (M − H)− 
               
               
                 1177 
                 SSC-AF-00 
                 2.035 
                 1405.5 
                 (M − H)− 
               
               
                 1178 
                 SSC-FA-03 
                 1.801 
                 1427.9 
                 (M − H)− 
               
               
                 1179 
                 SSC-A-FA-01 
                 6.292 
                 1505.6 
                 (M + H)+ 
               
               
                 1180 
                 SSC-FA-03 
                 1.896 
                 1427.9 
                 (M − H)− 
               
               
                 1181 
                 SSC-AF-00 
                 2.084 
                 1483.0 
                 (M − H)− 
               
               
                 1182 
                 SSC-A-FA-01 
                 5.596 
                 1565.7 
                 (M − H)− 
               
               
                 1183 
                 SSC-A-AF-01 
                 7.759 
                 1515.6 
                 (M + H)+ 
               
               
                 1184 
                 SSC-FA-03 
                 1.736 
                 1389.8 
                 (M − H)− 
               
               
                 1185 
                 SSC-FA-03 
                 2.019 
                 1354.6 
                 (M − H)− 
               
               
                 1186 
                 SSC-AF-00 
                 2.239 
                 1453.9 
                 (M − H)− 
               
               
                 1187 
                 SSC-FA-03 
                 1.635 
                 1345.7 
                 (M − H)− 
               
               
                 1188 
                 SSC-FA-03 
                 1.771 
                 1399.8 
                 (M − H)− 
               
               
                 1189 
                 SSC-A-AF-01 
                 7.953 
                 1455.8 
                 (M − H)− 
               
               
                 1190 
                 SSC-A-AF-01 
                 7.725 
                 1501.8 
                 (M − H)− 
               
               
                 1191 
                 SSC-AF-00 
                 2.101 
                 1456.9 
                 (M − H)− 
               
               
                 1192 
                 SSC-A-FA-01 
                 6.016 
                 1450.0 
                 (M − H)− 
               
               
                 1193 
                 SSC-A-AF-01 
                 7.640 
                 1469.8 
                 (M − H)− 
               
               
                 1194 
                 SSC-A-FA-01 
                 6.040 
                 1477.9 
                 (M − H)− 
               
               
                 1195 
                 SSC-FA-03 
                 1.763 
                 1401.5 
                 (M − H)− 
               
               
                 1196 
                 SSC-A-FA-01 
                 5.849 
                 1549.9 
                 (M − H)− 
               
               
                 1197 
                 SSC-A-FA-01 
                 5.459 
                 1422.0 
                 (M − H)− 
               
               
                 1198 
                 SSC-A-AF-01 
                 7.805 
                 1437.8 
                 (M − H)− 
               
               
                 1199 
                 SSC-A-FA-01 
                 5.912 
                 1449.8 
                 (M − H)− 
               
               
                 1200 
                 SSC-FA-03 
                 1.781 
                 1415.5 
                 (M + H)+ 
               
               
                 1201 
                 SSC-A-FA-01 
                 5.771 
                 1458.1 
                 (M − H)− 
               
               
                 1202 
                 SSC-AF-00 
                 2.189 
                 1455.6 
                 (M − H)− 
               
               
                 1203 
                 SSC-FA-03 
                 2.121 
                 1454.0 
                 (M − H)− 
               
               
                 1204 
                 SSC-A-FA-01 
                 6.067 
                 1467.9 
                 (M − H)− 
               
               
                 1205 
                 SSC-A-FA-01 
                 5.767 
                 1410.1 
                 (M − H)− 
               
               
                 1206 
                 SSC-A-AF-01 
                 7.420 
                 1573.7 
                 (M − H)− 
               
               
                 1207 
                 SSC-FA-03 
                 2.064 
                 1497.9 
                 (M − H)− 
               
               
                 1208 
                 SSC-A-AF-01 
                 7.500 
                 1439.6 
                 (M − H)− 
               
               
                 1209 
                 SSC-A-FA-01 
                 5.433 
                 1466.1 
                 (M − H)− 
               
               
                 1210 
                 SSC-A-AF-01 
                 7.595 
                 1534.0 
                 (M − H)− 
               
               
                 1211 
                 SSC-FA-03 
                 1.887 
                 1385.9 
                 (M − H)− 
               
               
                 1212 
                 SSC-FA-03 
                 1.771 
                 1423.5 
                 (M + H)+ 
               
               
                 1213 
                 SSC-AF-00 
                 2.108 
                 1335.0 
                 (M − H)− 
               
               
                 1214 
                 SSC-FA-03 
                 1.809 
                 1439.8 
                 (M − H)− 
               
               
                 1215 
                 SSC-A-FA-01 
                 5.611 
                 1504.1 
                 (M − H)− 
               
               
                 1216 
                 SSC-FA-03 
                 1.849 
                 1399.4 
                 (M − H)− 
               
               
                 1217 
                 SSC-A-AF-01 
                 7.496 
                 1437.7 
                 (M + H)+ 
               
               
                 1218 
                 SSC-FA-03 
                 1.948 
                 1362.6 
                 (M − H)− 
               
               
                 1219 
                 SSC-AF-00 
                 2.119 
                 1473.8 
                 (M − H)− 
               
               
                 1220 
                 SSC-A-FA-01 
                 5.807 
                 1469.6 
                 (M + H)+ 
               
               
                 1221 
                 SSC-AF-00 
                 2.115 
                 1308.5 
                 (M − H)− 
               
               
                 1222 
                 SSC-AF-00 
                 2.113 
                 1308.7 
                 (M − H)− 
               
               
                 1223 
                 SSC-A-AF-01 
                 7.413 
                 1425.8 
                 (M − H)− 
               
               
                 1224 
                 SSC-A-FA-01 
                 5.505 
                 1466.0 
                 (M − H)− 
               
               
                 1225 
                 SSC-FA-03 
                 1.799 
                 1306.9 
                 (M − H)− 
               
               
                 1226 
                 SSC-FA-03 
                 1.891 
                 1455.9 
                 (M + H)+ 
               
               
                 1227 
                 SSC-FA-03 
                 2.128 
                 1454.0 
                 (M − H)− 
               
               
                 1228 
                 SSC-A-AF-01 
                 7.584 
                 1454.0 
                 (M − H)− 
               
               
                 1229 
                 SSC-FA-03 
                 2.159 
                 1547.8 
                 (M − H)− 
               
               
                 1230 
                 SSC-AF-00 
                 2.075 
                 1433.8 
                 (M − H)− 
               
               
                 1231 
                 SSC-A-FA-01 
                 5.629 
                 1441.7 
                 (M + H)+ 
               
               
                 1232 
                 SSC-A-AF-01 
                 7.825 
                 1448.0 
                 (M − H)− 
               
               
                 1233 
                 SSC-A-AF-01 
                 7.552 
                 1503.7 
                 (M − H)− 
               
               
                 1234 
                 SSC-A-FA-01 
                 5.547 
                 1517.8 
                 (M − H)− 
               
               
                 1235 
                 SSC-AF-00 
                 2.152 
                 1453.9 
                 (M − H)− 
               
               
                 1236 
                 SSC-A-FA-01 
                 5.704 
                 1501.8 
                 (M − H)− 
               
               
                 1237 
                 SSC-A-AF-01 
                 7.513 
                 1440.0 
                 (M − H)− 
               
               
                 1238 
                 SSC-FA-03 
                 1.759 
                 1475.7 
                 (M − H)− 
               
               
                 1239 
                 SSC-FA-03 
                 1.735 
                 1294.6 
                 (M − H)− 
               
               
                 1240 
                 SSC-FA-03 
                 1.597 
                 1388.6 
                 (M − H)− 
               
               
                 1241 
                 SSC-A-AF-01 
                 7.871 
                 1455.6 
                 (M − H)− 
               
               
                 1242 
                 SSC-A-FA-01 
                 5.708 
                 1523.7 
                 (M − H)− 
               
               
                 1243 
                 SSC-FA-03 
                 1.995 
                 1413.9 
                 (M − H)− 
               
               
                 1244 
                 SSC-A-FA-01 
                 5.623 
                 1516.0 
                 (M − H)− 
               
               
                 1245 
                 SSC-A-FA-01 
                 5.728 
                 1495.5 
                 (M − H)− 
               
               
                 1246 
                 SSC-AF-00 
                 2.047 
                 1431.8 
                 (M − H)− 
               
               
                 1247 
                 SSC-AF-00 
                 2.125 
                 1387.4 
                 (M − H)− 
               
               
                 1248 
                 SSC-A-FA-01 
                 5.768 
                 1464.0 
                 (M + H)+ 
               
               
                 1249 
                 SSC-AF-00 
                 2.044 
                 1453.9 
                 (M − H)− 
               
               
                 1250 
                 SSC-A-FA-01 
                 5.671 
                 1500.1 
                 (M − H)− 
               
               
                 1251 
                 SSC-A-FA-01 
                 5.504 
                 1481.8 
                 (M − H)− 
               
               
                 1252 
                 SSC-A-FA-01 
                 5.383 
                 1396.0 
                 (M − H)− 
               
               
                 1253 
                 SSC-A-FA-01 
                 5.845 
                 1414.1 
                 (M − H)− 
               
               
                 1254 
                 SSC-A-AF-01 
                 7.511 
                 1525.5 
                 (M − H)− 
               
               
                 1255 
                 SSC-FA-03 
                 2.147 
                 1453.8 
                 (M − H)− 
               
               
                 1256 
                 SSC-FA-03 
                 1.660 
                 1345.7 
                 (M − H)− 
               
               
                 1257 
                 SSC-FA-03 
                 1.857 
                 1427.8 
                 (M − H)− 
               
               
                 1258 
                 SSC-FA-03 
                 1.849 
                 1483.8 
                 (M − H)− 
               
               
                 1259 
                 SSC-A-FA-01 
                 5.759 
                 1499.6 
                 (M + H)+ 
               
               
                 1260 
                 SSC-A-FA-01 
                 5.477 
                 1567.9 
                 (M − H)− 
               
               
                 1261 
                 SSC-A-FA-01 
                 5.271 
                 1550.1 
                 (M − H)− 
               
               
                 1262 
                 SSC-A-AF-01 
                 7.683 
                 1424.0 
                 (M − H)− 
               
               
                 1263 
                 SSC-AF-00 
                 2.123 
                 1489.6 
                 (M − H)− 
               
               
                 1264 
                 SSC-A-FA-01 
                 5.695 
                 1432.1 
                 (M − H)− 
               
               
                 1265 
                 SSC-FA-03 
                 2.044 
                 1507.7 
                 (M − H)− 
               
               
                 1266 
                 SSC-A-AF-01 
                 7.741 
                 1455.9 
                 (M + H)+ 
               
               
                 1267 
                 SSC-A-AF-01 
                 7.871 
                 1455.9 
                 (M − H)− 
               
               
                 1268 
                 SSC-FA-03 
                 1.655 
                 1345.7 
                 (M − H)− 
               
               
                 1269 
                 SSC-A-AF-01 
                 7.455 
                 1431.8 
                 (M − H)− 
               
               
                 1270 
                 SSC-A-AF-01 
                 7.739 
                 1447.8 
                 (M − H)− 
               
               
                 1271 
                 SSC-A-FA-01 
                 5.608 
                 1560.0 
                 (M − H)− 
               
               
                 1272 
                 SSC-A-FA-01 
                 5.901 
                 1468.0 
                 (M − H)− 
               
               
                 1273 
                 SSC-FA-03 
                 1.960 
                 1414.0 
                 (M − H)− 
               
               
                 1274 
                 SSC-AF-00 
                 2.204 
                 1425.8 
                 (M − H)− 
               
               
                 1275 
                 SSC-A-FA-01 
                 5.880 
                 1426.1 
                 (M − H)− 
               
               
                 1276 
                 SSC-AF-00 
                 2.192 
                 1440.0 
                 (M − H)− 
               
               
                 1277 
                 SSC-AF-00 
                 2.135 
                 1401.6 
                 (M − H)− 
               
               
                 1278 
                 SSC-A-AF-01 
                 7.327 
                 1461.5 
                 (M − H)− 
               
               
                 1279 
                 SSC-FA-03 
                 1.817 
                 1449.9 
                 (M − H)− 
               
               
                 1280 
                 SSC-AF-00 
                 2.203 
                 1425.6 
                 (M − H)− 
               
               
                 1281 
                 SSC-A-FA-01 
                 6.031 
                 1490.0 
                 (M − H)− 
               
               
                 1282 
                 SSC-A-AF-01 
                 7.433 
                 1419.9 
                 (M − H)− 
               
               
                 1283 
                 SSC-A-FA-01 
                 5.857 
                 1460.0 
                 (M − H)− 
               
               
                 1284 
                 SSC-FA-03 
                 1.616 
                 1496.8 
                 (M − H)− 
               
               
                 1285 
                 SSC-A-FA-01 
                 5.607 
                 1463.8 
                 (M − H)− 
               
               
                 1286 
                 SSC-AF-00 
                 2.145 
                 1459.6 
                 (M − H)− 
               
               
                 1287 
                 SSC-A-FA-01 
                 5.337 
                 1409.5 
                 (M + H)+ 
               
               
                 1288 
                 SSC-FA-03 
                 1.876 
                 1499.9 
                 (M − H)− 
               
               
                 1289 
                 SSC-A-AF-01 
                 7.719 
                 1503.7 
                 (M + H)+ 
               
               
                 1290 
                 SSC-A-AF-01 
                 7.801 
                 1488.1 
                 (M − H)− 
               
               
                 1291 
                 SSC-FA-03 
                 2.011 
                 1439.8 
                 (M − H)− 
               
               
                 1292 
                 SSC-A-FA-01 
                 5.412 
                 1396.0 
                 (M − H)− 
               
               
                 1293 
                 SSC-A-FA-01 
                 5.055 
                 1491.9 
                 (M + H)+ 
               
               
                 1294 
                 SSC-FA-03 
                 1.456 
                 1468.8 
                 (M − H)− 
               
               
                 1295 
                 SSC-A-AF-01 
                 7.777 
                 1462.1 
                 (M − H)− 
               
               
                 1296 
                 SSC-A-FA-01 
                 5.695 
                 1455.9 
                 (M − H)− 
               
               
                 1297 
                 SSC-A-FA-01 
                 5.351 
                 1576.0 
                 (M − H)− 
               
               
                 1298 
                 SSC-AF-00 
                 2.095 
                 1485.7 
                 (M − H)− 
               
               
                 1299 
                 SSC-A-FA-01 
                 5.024 
                 1441.8 
                 (M − H)− 
               
               
                 1300 
                 SSC-FA-03 
                 1.745 
                 1258.8 
                 (M − H)− 
               
               
                 1301 
                 SSC-A-FA-01 
                 5.500 
                 1507.6 
                 (M + H)+ 
               
               
                 1302 
                 SSC-FA-03 
                 2.048 
                 1428.0 
                 (M − H)− 
               
               
                 1303 
                 SSC-A-AF-01 
                 7.389 
                 1551.9 
                 (M − H)− 
               
               
                 1304 
                 SSC-AF-00 
                 2.033 
                 1405.7 
                 (M − H)− 
               
               
                 1305 
                 SSC-AF-00 
                 2.088 
                 1333.6 
                 (M − H)− 
               
               
                 1306 
                 SSC-A-FA-01 
                 5.596 
                 1458.0 
                 (M − H)− 
               
               
                 1307 
                 SSC-FA-03 
                 1.875 
                 1322.5 
                 (M − H)− 
               
               
                 1308 
                 SSC-A-AF-01 
                 7.648 
                 1456.0 
                 (M − H)− 
               
               
                 1309 
                 SSC-A-FA-01 
                 4.709 
                 1411.9 
                 (M − H)− 
               
               
                 1310 
                 SSC-A-AF-01 
                 7.676 
                 1489.7 
                 (M + H)+ 
               
               
                 1311 
                 SSC-A-FA-01 
                 5.421 
                 1539.7 
                 (M − H)− 
               
               
                 1312 
                 SSC-A-AF-01 
                 7.629 
                 1517.9 
                 (M − H)− 
               
               
                 1313 
                 SSC-FA-03 
                 1.787 
                 1415.8 
                 (M − H)− 
               
               
                 1314 
                 SSC-AF-00 
                 2.147 
                 1399.9 
                 (M − H)− 
               
               
                 1315 
                 SSC-AF-00 
                 2.208 
                 1425.8 
                 (M − H)− 
               
               
                 1316 
                 SSC-AF-00 
                 2.163 
                 1399.9 
                 (M − H)− 
               
               
                 1317 
                 SSC-A-FA-01 
                 5.619 
                 1499.6 
                 (M + H)+ 
               
               
                 1318 
                 SSC-AF-00 
                 2.124 
                 1355.7 
                 (M − H)− 
               
               
                 1319 
                 SSC-A-FA-01 
                 5.979 
                 1501.7 
                 (M − H)− 
               
               
                 1320 
                 SSC-A-AF-01 
                 7.676 
                 1501.8 
                 (M + H)+ 
               
               
                 1321 
                 SSC-FA-03 
                 1.956 
                 1468.0 
                 (M − H)− 
               
               
                 1322 
                 SSC-A-FA-01 
                 5.521 
                 1463.9 
                 (M − H)− 
               
               
                 1323 
                 SSC-AF-00 
                 2.195 
                 1439.9 
                 (M − H)− 
               
               
                 1324 
                 SSC-A-AF-01 
                 7.652 
                 1410.0 
                 (M − H)− 
               
               
                 1325 
                 SSC-A-FA-01 
                 5.819 
                 1447.9 
                 (M − H)− 
               
               
                 1326 
                 SSC-A-FA-01 
                 5.428 
                 1455.8 
                 (M − H)− 
               
               
                 1327 
                 SSC-AF-00 
                 2.064 
                 1407.8 
                 (M − H)− 
               
               
                 1328 
                 SSC-AF-00 
                 2.117 
                 1324.5 
                 (M + H)+ 
               
               
                 1329 
                 SSC-FA-03 
                 1.792 
                 1413.5 
                 (M − H)− 
               
               
                 1330 
                 SSC-A-FA-01 
                 5.368 
                 1547.6 
                 (M − H)− 
               
               
                 1331 
                 SSC-AF-00 
                 2.116 
                 1334.5 
                 (M − H)− 
               
               
                 1332 
                 SSC-FA-03 
                 1.908 
                 1340.5 
                 (M − H)− 
               
               
                 1333 
                 SSC-AF-00 
                 2.163 
                 1441.8 
                 (M − H)− 
               
               
                 1334 
                 SSC-AF-00 
                 2.147 
                 1411.8 
                 (M − H)− 
               
               
                 1335 
                 SSC-A-AF-01 
                 7.671 
                 1531.8 
                 (M − H)− 
               
               
                 1336 
                 SSC-A-AF-01 
                 7.255 
                 1428.0 
                 (M − H)− 
               
               
                 1337 
                 SSC-A-FA-02 
                 6.216 
                 1481.7 
                 (M + H)+ 
               
               
                 1338 
                 SSC-A-FA-01 
                 5.437 
                 1469.9 
                 (M − H)− 
               
               
                 1339 
                 SSC-A-FA-01 
                 5.604 
                 1503.9 
                 (M − H)− 
               
               
                 1340 
                 SSC-A-FA-01 
                 5.424 
                 1408.0 
                 (M − H)− 
               
               
                 1341 
                 SSC-A-FA-01 
                 6.053 
                 1514.0 
                 (M − H)− 
               
               
                 1342 
                 SSC-A-AF-01 
                 7.621 
                 1414.1 
                 (M − H)− 
               
               
                 1343 
                 SSC-A-FA-01 
                 5.456 
                 1490.0 
                 (M − H)− 
               
               
                 1344 
                 SSC-FA-03 
                 1.691 
                 1419.7 
                 (M − H)− 
               
               
                 1345 
                 SSC-FA-03 
                 2.153 
                 1454.0 
                 (M − H)− 
               
               
                 1346 
                 SSC-A-FA-01 
                 5.835 
                 1449.9 
                 (M − H)− 
               
               
                 1347 
                 SSC-FA-03 
                 2.111 
                 1453.8 
                 (M − H)− 
               
               
                 1348 
                 SSC-A-FA-01 
                 5.337 
                 1543.6 
                 (M + H)+ 
               
               
                 1349 
                 SSC-FA-03 
                 1.755 
                 1463.5 
                 (M + H)+ 
               
               
                 1350 
                 SSC-AF-00 
                 2.072 
                 1445.9 
                 (M − H)− 
               
               
                 1351 
                 SSC-A-FA-01 
                 5.725 
                 1450.0 
                 (M − H)− 
               
               
                 1352 
                 SSC-FA-03 
                 1.920 
                 1475.3 
                 (M − H)− 
               
               
                 1353 
                 SSC-AF-00 
                 2.163 
                 1412.0 
                 (M − H)− 
               
               
                 1354 
                 SSC-AF-00 
                 2.216 
                 1426.0 
                 (M − H)− 
               
               
                 1355 
                 SSC-A-AF-01 
                 7.425 
                 1457.9 
                 (M − H)− 
               
               
                 1356 
                 SSC-A-AF-01 
                 7.568 
                 1503.7 
                 (M − H)− 
               
               
                 1357 
                 SSC-A-FA-01 
                 6.156 
                 1487.8 
                 (M − H)− 
               
               
                 1358 
                 SSC-AF-00 
                 2.095 
                 1449.8 
                 (M − H)− 
               
               
                 1359 
                 SSC-A-FA-01 
                 5.357 
                 1467.9 
                 (M − H)− 
               
               
                 1360 
                 SSC-A-AF-01 
                 7.449 
                 1473.6 
                 (M − H)− 
               
               
                 1361 
                 SSC-FA-03 
                 1.813 
                 1457.8 
                 (M − H)− 
               
               
                 1362 
                 SSC-A-FA-01 
                 5.183 
                 1506.0 
                 (M − H)− 
               
               
                 1363 
                 SSC-A-AF-01 
                 7.851 
                 1460.0 
                 (M − H)− 
               
               
                 1364 
                 SSC-A-FA-01 
                 5.587 
                 1520.0 
                 (M − H)− 
               
               
                 1365 
                 SSC-A-FA-01 
                 5.475 
                 1422.0 
                 (M − H)− 
               
               
                 1366 
                 SSC-A-FA-02 
                 6.213 
                 1459.7 
                 (M + H)+ 
               
               
                 1367 
                 SSC-A-FA-01 
                 5.889 
                 1458.1 
                 (M − H)− 
               
               
                 1368 
                 SSC-A-AF-01 
                 7.532 
                 1478.0 
                 (M − H)− 
               
               
                 1369 
                 SSC-A-FA-01 
                 5.992 
                 1495.8 
                 (M − H)− 
               
               
                 1370 
                 SSC-A-FA-01 
                 5.833 
                 1457.7 
                 (M + H)+ 
               
               
                 1371 
                 SSC-A-FA-01 
                 5.392 
                 1517.9 
                 (M + H)+ 
               
               
                 1372 
                 SSC-FA-03 
                 1.871 
                 1405.7 
                 (M − H)− 
               
               
                 1373 
                 SSC-TFA-07 
                 1.352 
                 1322.8 
                 (M + H)+ 
               
               
                 1374 
                 SSC-A-AF-01 
                 8.067 
                 1457.7 
                 (M + H)+ 
               
               
                 1375 
                 SSC-TFA-07 
                 1.348 
                 1322.7 
                 (M + H)+ 
               
               
                 1376 
                 SSC-AF-00 
                 2.192 
                 1455.9 
                 (M − H)− 
               
               
                 1377 
                 SSC-FA-03 
                 1.755 
                 1284.4 
                 (M − H)− 
               
               
                 1378 
                 SSC-AF-00 
                 2.161 
                 1290.9 
                 (M − H)− 
               
               
                 1379 
                 SSC-FA-03 
                 2.015 
                 1340.5 
                 (M − H)− 
               
               
                 1380 
                 SSC-FA-03 
                 1.821 
                 1264.5 
                 (M − H)− 
               
               
                 1381 
                 SSC-FA-03 
                 1.829 
                 1286.9 
                 (M − H)− 
               
               
                 1382 
                 SSC-AF-00 
                 2.132 
                 1300.5 
                 (M + H)+ 
               
               
                 1383 
                 SSC-FA-03 
                 1.863 
                 1352.5 
                 (M − H)− 
               
               
                 1384 
                 SSC-AF-00 
                 2.185 
                 1330.6 
                 (M + H)+ 
               
               
                 1385 
                 SSC-FA-03 
                 1.845 
                 1342.4 
                 (M + H)+ 
               
               
                 1386 
                 SSC-FA-03 
                 1.875 
                 1326.7 
                 (M − H)− 
               
               
                 1387 
                 SSC-FA-03 
                 1.816 
                 1276.5 
                 (M − H)− 
               
               
                 1388 
                 SSC-AF-00 
                 2.144 
                 1314.6 
                 (M − H)− 
               
               
                 1389 
                 SSC-AF-00 
                 2.217 
                 1320.9 
                 (M − H)− 
               
               
                 1390 
                 SSC-FA-03 
                 1.905 
                 1278.9 
                 (M − H)− 
               
               
                 1391 
                 SSC-AF-00 
                 2.160 
                 1290.9 
                 (M − H)− 
               
               
                 1392 
                 SSC-AF-00 
                 2.072 
                 1340.4 
                 (M + H)+ 
               
               
                 1393 
                 SSC-AF-00 
                 2.173 
                 1382.4 
                 (M − H)− 
               
               
                 1394 
                 SSC-AF-00 
                 2.188 
                 1340.9 
                 (M − H)− 
               
               
                 1395 
                 SSC-FA-03 
                 1.969 
                 1394.9 
                 (M − H)− 
               
               
                 1396 
                 SSC-FA-03 
                 1.905 
                 1368.8 
                 (M − H)− 
               
               
                 1397 
                 SSC-FA-03 
                 1.792 
                 1328.6 
                 (M + H)+ 
               
               
                 1398 
                 SSC-FA-03 
                 1.763 
                 1272.8 
                 (M − H)− 
               
               
                 1399 
                 SSC-AF-00 
                 2.120 
                 1352.8 
                 (M − H)− 
               
               
                 1400 
                 SSC-FA-03 
                 2.071 
                 1333.0 
                 (M − H)− 
               
               
                 1401 
                 SSC-FA-03 
                 2.001 
                 1394.4 
                 (M − H)− 
               
               
                 1402 
                 SSC-AF-00 
                 2.124 
                 1298.9 
                 (M − H)− 
               
               
                 1403 
                 SSC-AF-00 
                 2.133 
                 1380.8 
                 (M − H)− 
               
               
                 1404 
                 SSC-AF-00 
                 2.133 
                 1393.8 
                 (M − H)− 
               
               
                 1405 
                 SSC-FA-03 
                 1.904 
                 1426.0 
                 (M + H)+ 
               
               
                 1406 
                 SSC-FA-03 
                 1.787 
                 1360.3 
                 (M − H)− 
               
               
                 1407 
                 SSC-TFA-07 
                 1.359 
                 1337.8 
                 (M + H)+ 
               
               
                 1408 
                 SSC-FA-03 
                 1.797 
                 1368.8 
                 (M − H)− 
               
               
                 1409 
                 SSC-TFA-07 
                 1.376 
                 1463.7 
                 (M + H)+ 
               
               
                 1410 
                 SSC-TFA-07 
                 1.348 
                 1415.7 
                 (M + H)+ 
               
               
                 1411 
                 SSC-FA-03 
                 1.672 
                 1345.6 
                 (M + H)+ 
               
               
                 1412 
                 SSC-TFA-07 
                 1.304 
                 1333.8 
                 (M + H)+ 
               
               
                 1413 
                 SSC-FA-03 
                 1.903 
                 1411.8 
                 (M − H)− 
               
               
                 1414 
                 SSC-AF-00 
                 2.113 
                 1451.7 
                 (M − H)− 
               
               
                 1415 
                 SSC-AF-00 
                 2.143 
                 1419.4 
                 (M − H)− 
               
               
                 1416 
                 SSC-AF-00 
                 2.180 
                 1413.9 
                 (M − H)− 
               
               
                 1417 
                 SSC-AF-00 
                 2.168 
                 1479.6 
                 (M + H)+ 
               
               
                 1418 
                 SSC-AF-00 
                 2.137 
                 1356.8 
                 (M − H)− 
               
               
                 1419 
                 SSC-FA-03 
                 1.985 
                 1479.7 
                 (M − H)− 
               
               
                 1420 
                 SSC-FA-03 
                 1.904 
                 1425.9 
                 (M − H)− 
               
               
                 1421 
                 SSC-FA-03 
                 1.847 
                 1439.8 
                 (M − H)− 
               
               
                 1422 
                 SSC-FA-03 
                 1.889 
                 1453.8 
                 (M − H)− 
               
               
                 1423 
                 SSC-AF-00 
                 2.152 
                 1401.5 
                 (M + H)+ 
               
               
                 1424 
                 SSC-TFA-07 
                 1.468 
                 1411.7 
                 (M + H)+ 
               
               
                 1425 
                 SSC-FA-03 
                 1.767 
                 1469.9 
                 (M − H)− 
               
               
                 1426 
                 SSC-FA-03 
                 1.793 
                 1423.3 
                 (M − H)− 
               
               
                 1427 
                 SSC-FA-03 
                 1.715 
                 1372.3 
                 (M − H)− 
               
               
                 1428 
                 SSC-AF-00 
                 2.105 
                 1449.8 
                 (M − H)− 
               
               
                 1429 
                 SSC-AF-00 
                 2.135 
                 1465.8 
                 (M − H)− 
               
               
                 1430 
                 SSC-TFA-07 
                 1.425 
                 1477.7 
                 (M + H)+ 
               
               
                 1431 
                 SSC-TFA-07 
                 1.339 
                 1413.6 
                 (M + H)+ 
               
               
                 1432 
                 SSC-TFA-07 
                 1.572 
                 1427.7 
                 (M + H)+ 
               
               
                 1433 
                 SSC-AF-00 
                 2.176 
                 1489.9 
                 (M − H)− 
               
               
                 1434 
                 SSC-AF-00 
                 2.301 
                 1515.9 
                 (M − H)− 
               
               
                 1435 
                 SSC-FA-03 
                 2.109 
                 1441.6 
                 (M − H)− 
               
               
                 1436 
                 SSC-AF-00 
                 2.333 
                 1513.9 
                 (M − H)− 
               
               
                 1437 
                 SSC-FA-03 
                 2.192 
                 1499.9 
                 (M − H)− 
               
               
                 1438 
                 SSC-FA-03 
                 2.000 
                 1427.9 
                 (M − H)− 
               
               
                 1439 
                 SSC-FA-03 
                 2.059 
                 1428.0 
                 (M − H)− 
               
               
                 1440 
                 SSC-AF-00 
                 2.315 
                 1499.9 
                 (M − H)− 
               
               
                 1441 
                 SSC-FA-03 
                 2.076 
                 1454.0 
                 (M − H)− 
               
               
                 1442 
                 SSC-AF-00 
                 2.263 
                 1489.8 
                 (M − H)− 
               
               
                 1443 
                 SSC-FA-03 
                 2.272 
                 1525.7 
                 (M − H)− 
               
               
                 1444 
                 SSC-FA-03 
                 1.881 
                 1429.9 
                 (M − H)− 
               
               
                 1445 
                 SSC-FA-03 
                 2.032 
                 1456.0 
                 (M − H)− 
               
               
                 1446 
                 SSC-AF-00 
                 2.268 
                 1489.9 
                 (M − H)− 
               
               
                 1447 
                 SSC-AF-00 
                 2.217 
                 1441.6 
                 (M + H)+ 
               
               
                 1448 
                 SSC-AF-00 
                 2.189 
                 1443.8 
                 (M − H)− 
               
               
                 1449 
                 SSC-FA-03 
                 2.140 
                 1453.8 
                 (M − H)− 
               
               
                 1450 
                 SSC-TFA-07 
                 1.500 
                 1487.9 
                 (M + H)+ 
               
               
                 1451 
                 SSC-AF-00 
                 2.087 
                 1318.7 
                 (M + H)+ 
               
               
                 1452 
                 SSC-TFA-07 
                 1.479 
                 1290.8 
                 (M + H)+ 
               
               
                 1453 
                 SSC-TFA-07 
                 1.403 
                 1411.8 
                 (M + H)+ 
               
               
                 1454 
                 SSC-TFA-07 
                 1.481 
                 1385.9 
                 (M + H)+ 
               
               
                 1455 
                 SSC-TFA-07 
                 1.360 
                 1385.8 
                 (M + H)+ 
               
               
                 1456 
                 SSC-TFA-07 
                 1.447 
                 1413.8 
                 (M + H)+ 
               
               
                 1457 
                 SSC-AF-00 
                 2.148 
                 1290.7 
                 (M + H)+ 
               
               
                 1458 
                 SSC-TFA-07 
                 1.468 
                 1385.9 
                 (M + H)+ 
               
               
                 1459 
                 SSC-TFA-07 
                 1.521 
                 1304.7 
                 (M + H)+ 
               
               
                 1460 
                 SSC-AF-00 
                 2.088 
                 1328.7 
                 (M + H)+ 
               
               
                 1461 
                 SSC-AF-00 
                 2.176 
                 1306.9 
                 (M − H)− 
               
               
                 1462 
                 SSC-FA-03 
                 1.760 
                 1292.5 
                 (M − H)− 
               
               
                 1463 
                 SSC-FA-03 
                 1.788 
                 1346.4 
                 (M − H)− 
               
               
                 1464 
                 SSC-AF-00 
                 2.151 
                 1398.5 
                 (M + H)+ 
               
               
                 1465 
                 SSC-FA-03 
                 1.892 
                 1294.6 
                 (M − H)− 
               
               
                 1466 
                 SSC-FA-03 
                 1.741 
                 1266.6 
                 (M − H)− 
               
               
                 1467 
                 SSC-TFA-07 
                 1.491 
                 1399.8 
                 (M + H)+ 
               
               
                 1468 
                 SSC-AF-00 
                 2.223 
                 1402.9 
                 (M − H)− 
               
               
                 1469 
                 SSC-TFA-07 
                 1.399 
                 1260.8 
                 (M + H)+ 
               
               
                 1470 
                 SSC-AF-00 
                 2.144 
                 1360.8 
                 (M − H)− 
               
               
                 1471 
                 SSC-AF-00 
                 2.149 
                 1322.9 
                 (M − H)− 
               
               
                 1472 
                 SSC-TFA-07 
                 1.485 
                 1384.7 
                 (M + H)+ 
               
               
                 1473 
                 SSC-AF-00 
                 2.161 
                 1384.9 
                 (M − H)− 
               
               
                 1474 
                 SSC-TFA-07 
                 1.453 
                 1274.8 
                 (M + H)+ 
               
               
                 1475 
                 SSC-FA-03 
                 1.916 
                 1402.8 
                 (M − H)− 
               
               
                 1476 
                 SSC-TFA-07 
                 1.439 
                 1372.7 
                 (M + H)+ 
               
               
                 1477 
                 SSC-FA-03 
                 1.993 
                 1340.9 
                 (M − H)− 
               
               
                 1478 
                 SSC-AF-00 
                 2.123 
                 1272.5 
                 (M − H)− 
               
               
                 1479 
                 SSC-FA-03 
                 1.939 
                 1310.5 
                 (M − H)− 
               
               
                 1480 
                 SSC-TFA-07 
                 1.536 
                 1510.9 
                 (M + H)+ 
               
               
                 1481 
                 SSC-FA-03 
                 1.839 
                 1284.9 
                 (M − H)− 
               
               
                 1482 
                 SSC-FA-03 
                 2.025 
                 1416.8 
                 (M − H)− 
               
               
                 1483 
                 SSC-TFA-07 
                 1.404 
                 1304.9 
                 (M + H)+ 
               
               
                 1484 
                 SSC-TFA-07 
                 1.471 
                 1372.7 
                 (M + H)+ 
               
               
                 1485 
                 SSC-FA-03 
                 1.763 
                 1280.9 
                 (M − H)− 
               
               
                 1486 
                 SSC-AF-00 
                 2.081 
                 1320.8 
                 (M − H)− 
               
               
                 1487 
                 SSC-AF-00 
                 2.183 
                 1348.9 
                 (M − H)− 
               
               
                 1488 
                 SSC-FA-03 
                 1.899 
                 1360.9 
                 (M − H)− 
               
               
                 1489 
                 SSC-TFA-07 
                 1.447 
                 1371.8 
                 (M + H)+ 
               
               
                 1490 
                 SSC-TFA-07 
                 1.484 
                 1288.8 
                 (M + H)+ 
               
               
                 1491 
                 SSC-FA-03 
                 1.851 
                 1298.9 
                 (M − H)− 
               
               
                 1492 
                 SSC-AF-00 
                 2.172 
                 1425.7 
                 (M + H)+ 
               
               
                 1493 
                 SSC-AF-00 
                 2.115 
                 1274.7 
                 (M + H)+ 
               
               
                 1494 
                 SSC-FA-03 
                 1.885 
                 1320.5 
                 (M + H)+ 
               
               
                 1495 
                 SSC-TFA-07 
                 1.515 
                 1413.8 
                 (M + H)+ 
               
               
                 1496 
                 SSC-FA-03 
                 1.883 
                 1388.4 
                 (M − H)− 
               
               
                 1497 
                 SSC-FA-03 
                 1.899 
                 1374.4 
                 (M − H)− 
               
               
                 1498 
                 SSC-FA-03 
                 1.873 
                 1308.5 
                 (M − H)− 
               
               
                 1499 
                 SSC-AF-00 
                 2.205 
                 1326.9 
                 (M − H)− 
               
               
                 1500 
                 SSC-FA-03 
                 1.883 
                 1334.9 
                 (M − H)− 
               
               
                 1501 
                 SSC-AF-00 
                 2.137 
                 1398.0 
                 (M − H)− 
               
               
                 1502 
                 SSC-TFA-07 
                 1.491 
                 1476.9 
                 (M + H)+ 
               
               
                 1503 
                 SSC-TFA-07 
                 1.529 
                 1304.8 
                 (M + H)+ 
               
               
                 1504 
                 SSC-FA-03 
                 1.984 
                 1362.6 
                 (M − H)− 
               
               
                 1505 
                 SSC-TFA-07 
                 1.560 
                 1386.7 
                 (M + H)+ 
               
               
                 1506 
                 SSC-FA-03 
                 1.796 
                 1258.5 
                 (M − H)− 
               
               
                 1507 
                 SSC-AF-00 
                 2.183 
                 1360.5 
                 (M − H)− 
               
               
                 1508 
                 SSC-FA-03 
                 1.895 
                 1362.4 
                 (M − H)− 
               
               
                 1509 
                 SSC-AF-00 
                 2.140 
                 1324.7 
                 (M + H)+ 
               
               
                 1510 
                 SSC-FA-03 
                 1.955 
                 1312.9 
                 (M − H)− 
               
               
                 1511 
                 SSC-TFA-07 
                 1.495 
                 1278.8 
                 (M + H)+ 
               
               
                 1512 
                 SSC-FA-03 
                 1.787 
                 1360.3 
                 (M − H)− 
               
               
                 1513 
                 SSC-TFA-07 
                 1.537 
                 1425.8 
                 (M + H)+ 
               
               
                 1514 
                 SSC-AF-00 
                 2.109 
                 1306.4 
                 (M − H)− 
               
               
                 1515 
                 SSC-TFA-07 
                 1.396 
                 1298.8 
                 (M + H)+ 
               
               
                 1516 
                 SSC-AF-00 
                 2.115 
                 1370.9 
                 (M − H)− 
               
               
                 1517 
                 SSC-AF-00 
                 2.225 
                 1348.9 
                 (M − H)− 
               
               
                 1518 
                 SSC-AF-00 
                 2.147 
                 1288.8 
                 (M + H)+ 
               
               
                 1519 
                 SSC-TFA-07 
                 1.475 
                 1372.7 
                 (M + H)+ 
               
               
                 1520 
                 SSC-AF-00 
                 2.172 
                 1350.4 
                 (M + H)+ 
               
               
                 1521 
                 SSC-AF-00 
                 2.223 
                 1336.9 
                 (M − H)− 
               
               
                 1522 
                 SSC-FA-03 
                 1.936 
                 1372.4 
                 (M − H)− 
               
               
                 1523 
                 SSC-FA-03 
                 1.784 
                 1334.4 
                 (M − H)− 
               
               
                 1524 
                 SSC-AF-00 
                 2.149 
                 1376.8 
                 (M − H)− 
               
               
                 1525 
                 SSC-AF-00 
                 2.136 
                 1306.9 
                 (M − H)− 
               
               
                 1526 
                 SSC-AF-00 
                 2.067 
                 1302.8 
                 (M + H)+ 
               
               
                 1527 
                 SSC-TFA-07 
                 1.536 
                 1314.8 
                 (M + H)+ 
               
               
                 1528 
                 SSC-TFA-07 
                 1.464 
                 1449.8 
                 (M + H)+ 
               
               
                 1529 
                 SSC-TFA-07 
                 1.404 
                 1304.8 
                 (M + H)+ 
               
               
                 1530 
                 SSC-AF-00 
                 2.263 
                 1329.0 
                 (M − H)− 
               
               
                 1531 
                 SSC-FA-03 
                 2.080 
                 1340.5 
                 (M − H)− 
               
               
                 1532 
                 SSC-AF-00 
                 2.113 
                 1451.9 
                 (M − H)− 
               
               
                 1533 
                 SSC-AF-00 
                 2.077 
                 1270.7 
                 (M + H)+ 
               
               
                 1534 
                 SSC-AF-00 
                 2.132 
                 1274.7 
                 (M + H)+ 
               
               
                 1535 
                 SSC-AF-00 
                 2.199 
                 1286.5 
                 (M − H)− 
               
               
                 1536 
                 SSC-AF-00 
                 2.164 
                 1320.9 
                 (M − H)− 
               
               
                 1537 
                 SSC-FA-03 
                 1.907 
                 1348.9 
                 (M − H)− 
               
               
                 1538 
                 SSC-TFA-07 
                 1.492 
                 1407.8 
                 (M + H)+ 
               
               
                 1539 
                 SSC-FA-03 
                 1.975 
                 1299.0 
                 (M − H)− 
               
               
                 1540 
                 SSC-FA-03 
                 1.861 
                 1332.5 
                 (M − H)− 
               
               
                 1541 
                 SSC-TFA-07 
                 1.477 
                 1469.8 
                 (M + H)+ 
               
               
                 1542 
                 SSC-AF-00 
                 2.224 
                 1390.4 
                 (M − H)− 
               
               
                 1543 
                 SSC-AF-00 
                 2.176 
                 1298.9 
                 (M − H)− 
               
               
                 1544 
                 SSC-FA-03 
                 1.931 
                 1300.5 
                 (M − H)− 
               
               
                 1545 
                 SSC-AF-00 
                 2.128 
                 1274.7 
                 (M + H)+ 
               
               
                 1546 
                 SSC-TFA-07 
                 1.431 
                 1358.7 
                 (M + H)+ 
               
               
                 1547 
                 SSC-TFA-07 
                 1.428 
                 1298.7 
                 (M + H)+ 
               
               
                 1548 
                 SSC-TFA-07 
                 1.632 
                 1358.7 
                 (M + H)+ 
               
               
                 1549 
                 SSC-TFA-07 
                 1.444 
                 1312.7 
                 (M + H)+ 
               
               
                 1550 
                 SSC-TFA-07 
                 1.444 
                 1312.6 
                 (M + H)+ 
               
               
                 1551 
                 SSC-AF-00 
                 2.079 
                 1326.4 
                 (M − H)− 
               
               
                 1552 
                 SSC-TFA-07 
                 1.727 
                 1495.8 
                 (M + H)+ 
               
               
                 1553 
                 SSC-TFA-07 
                 1.556 
                 1453.8 
                 (M + H)+ 
               
               
                 1554 
                 SSC-TFA-07 
                 1.699 
                 1467.7 
                 (M + H)+ 
               
               
                 1555 
                 SSC-TFA-07 
                 1.499 
                 1463.7 
                 (M + H)+ 
               
               
                 1556 
                 SSC-TFA-07 
                 1.405 
                 1302.6 
                 (M + H)+ 
               
               
                 1557 
                 SSC-TFA-07 
                 1.443 
                 1413.7 
                 (M + H)+ 
               
               
                 1558 
                 SSC-TFA-07 
                 1.657 
                 1469.7 
                 (M + H)+ 
               
               
                 1559 
                 SSC-AF-00 
                 2.203 
                 1473.9 
                 (M − H)− 
               
               
                 1560 
                 SSC-TFA-07 
                 1.587 
                 1344.7 
                 (M + H)+ 
               
               
                 1561 
                 SSC-TFA-07 
                 1.689 
                 1503.7 
                 (M + H)+ 
               
               
                 1562 
                 SSC-TFA-07 
                 1.425 
                 1385.6 
                 (M + H)+ 
               
               
                 1563 
                 SSC-TFA-07 
                 1.493 
                 1382.6 
                 (M + H)+ 
               
               
                 1564 
                 SSC-TFA-07 
                 1.476 
                 1302.7 
                 (M + H)+ 
               
               
                 1565 
                 SSC-AF-00 
                 2.140 
                 1366.8 
                 (M − H)− 
               
               
                 1566 
                 SSC-AF-00 
                 2.211 
                 1451.8 
                 (M − H)− 
               
               
                 1567 
                 SSC-TFA-07 
                 1.473 
                 1366.6 
                 (M + H)+ 
               
               
                 1568 
                 SSC-TFA-07 
                 1.525 
                 1316.7 
                 (M + H)+ 
               
               
                 1569 
                 SSC-AF-00 
                 2.208 
                 1440.0 
                 (M − H)− 
               
               
                 1570 
                 SSC-AF-00 
                 2.100 
                 1310.5 
                 (M − H)− 
               
               
                 1571 
                 SSC-TFA-07 
                 1.417 
                 1316.6 
                 (M + H)+ 
               
               
                 1572 
                 SSC-TFA-07 
                 1.484 
                 1366.6 
                 (M + H)+ 
               
               
                 1573 
                 SSC-TFA-07 
                 1.480 
                 1368.6 
                 (M + H)+ 
               
               
                 1574 
                 SSC-TFA-07 
                 1.760 
                 1509.8 
                 (M + H)+ 
               
               
                 1575 
                 SSC-TFA-07 
                 1.461 
                 1352.7 
                 (M + H)+ 
               
               
                 1576 
                 SSC-TFA-07 
                 1.473 
                 1473.6 
                 (M + H)+ 
               
               
                 1577 
                 SSC-AF-00 
                 2.279 
                 1482.0 
                 (M − H)− 
               
               
                 1578 
                 SSC-TFA-07 
                 1.391 
                 1274.6 
                 (M + H)+ 
               
               
                 1579 
                 SSC-TFA-07 
                 1.493 
                 1463.7 
                 (M + H)+ 
               
               
                 1580 
                 SSC-TFA-07 
                 1.624 
                 1467.8 
                 (M + H)+ 
               
               
                 1581 
                 SSC-AF-00 
                 2.301 
                 1397.0 
                 (M − H)− 
               
               
                 1582 
                 SSC-TFA-07 
                 1.447 
                 1334.5 
                 (M + H)+ 
               
               
                 1583 
                 SSC-TFA-07 
                 1.445 
                 1413.7 
                 (M + H)+ 
               
               
                 1584 
                 SSC-AF-00 
                 2.131 
                 1407.9 
                 (M − H)− 
               
               
                 1585 
                 SSC-TFA-07 
                 1.403 
                 1302.6 
                 (M + H)+ 
               
               
                 1586 
                 SSC-AF-00 
                 2.201 
                 1340.4 
                 (M − H)− 
               
               
                 1587 
                 SSC-TFA-07 
                 1.452 
                 1362.5 
                 (M + H)+ 
               
               
                 1588 
                 SSC-TFA-07 
                 1.425 
                 1425.7 
                 (M + H)+ 
               
               
                 1589 
                 SSC-TFA-07 
                 1.472 
                 1348.6 
                 (M + H)+ 
               
               
                 1590 
                 SSC-TFA-07 
                 1.459 
                 1376.5 
                 (M + H)+ 
               
               
                 1591 
                 SSC-TFA-07 
                 1.424 
                 1318.6 
                 (M + H)+ 
               
               
                 1592 
                 SSC-AF-00 
                 2.233 
                 1454.0 
                 (M − H)− 
               
               
                 1593 
                 SSC-AF-00 
                 2.204 
                 1328.5 
                 (M − H)− 
               
               
                 1594 
                 SSC-AF-00 
                 2.124 
                 1409.5 
                 (M + H)+ 
               
               
                 1595 
                 SSC-TFA-07 
                 1.587 
                 1441.7 
                 (M + H)+ 
               
               
                 1596 
                 SSC-AF-00 
                 2.252 
                 1468.0 
                 (M − H)− 
               
               
                 1597 
                 SSC-TFA-07 
                 1.473 
                 1376.5 
                 (M + H)+ 
               
               
                 1598 
                 SSC-AF-00 
                 2.101 
                 1393.8 
                 (M − H)− 
               
               
                 1599 
                 SSC-TFA-07 
                 1.425 
                 1316.7 
                 (M + H)+ 
               
               
                 1600 
                 SSC-TFA-07 
                 1.740 
                 1495.8 
                 (M + H)+ 
               
               
                 1601 
                 SSC-AF-00 
                 2.221 
                 1454.0 
                 (M − H)− 
               
               
                 1602 
                 SSC-TFA-07 
                 1.400 
                 1302.6 
                 (M + H)+ 
               
               
                 1603 
                 SSC-AF-00 
                 2.259 
                 1480.1 
                 (M − H)− 
               
               
                 1604 
                 SSC-TFA-07 
                 1.416 
                 1298.7 
                 (M + H)+ 
               
               
                 1605 
                 SSC-TFA-07 
                 1.393 
                 1314.6 
                 (M + H)+ 
               
               
                 1606 
                 SSC-TFA-07 
                 1.395 
                 1284.6 
                 (M + H)+ 
               
               
                 1607 
                 SSC-TFA-07 
                 1.433 
                 1288.6 
                 (M + H)+ 
               
               
                 1608 
                 SSC-AF-00 
                 2.131 
                 1407.5 
                 (M − H)− 
               
               
                 1609 
                 SSC-TFA-07 
                 1.491 
                 1445.7 
                 (M + H)+ 
               
               
                 1610 
                 SSC-TFA-07 
                 1.427 
                 1316.7 
                 (M + H)+ 
               
               
                 1611 
                 SSC-AF-00 
                 2.136 
                 1427.7 
                 (M − H)− 
               
               
                 1612 
                 SSC-TFA-07 
                 1.609 
                 1356.7 
                 (M + H)+ 
               
               
                 1613 
                 SSC-TFA-07 
                 1.453 
                 1352.6 
                 (M + H)+ 
               
               
                 1614 
                 SSC-TFA-07 
                 1.416 
                 1298.7 
                 (M + H)+ 
               
               
                 1615 
                 SSC-TFA-07 
                 1.445 
                 1332.5 
                 (M + H)+ 
               
               
                 1616 
                 SSC-TFA-07 
                 1.557 
                 1427.6 
                 (M + H)+ 
               
               
                 1617 
                 SSC-TFA-07 
                 1.467 
                 1366.5 
                 (M + H)+ 
               
               
                 1618 
                 SSC-AF-00 
                 2.281 
                 1382.9 
                 (M − H)− 
               
               
                 1619 
                 SSC-TFA-07 
                 1.617 
                 1358.6 
                 (M + H)+ 
               
               
                 1620 
                 SSC-TFA-07 
                 1.447 
                 1352.6 
                 (M + H)+ 
               
               
                 1621 
                 SSC-TFA-07 
                 1.463 
                 1332.6 
                 (M + H)+ 
               
               
                 1622 
                 SSC-AF-00 
                 2.221 
                 1452.0 
                 (M − H)− 
               
               
                 1623 
                 SSC-TFA-07 
                 1.443 
                 1318.6 
                 (M + H)+ 
               
               
                 1624 
                 SSC-TFA-07 
                 1.700 
                 1517.8 
                 (M + H)+ 
               
               
                 1625 
                 SSC-TFA-07 
                 1.441 
                 1362.5 
                 (M + H)+ 
               
               
                 1626 
                 SSC-AF-00 
                 2.128 
                 1407.9 
                 (M − H)− 
               
               
                 1627 
                 SSC-TFA-07 
                 1.431 
                 1298.7 
                 (M + H)+ 
               
               
                 1628 
                 SSC-AF-00 
                 2.244 
                 1390.9 
                 (M − H)− 
               
               
                 1629 
                 SSC-TFA-07 
                 1.481 
                 1463.8 
                 (M + H)+ 
               
               
                 1630 
                 SSC-AF-00 
                 2.155 
                 1477.7 
                 (M − H)− 
               
               
                 1631 
                 SSC-AF-00 
                 2.104 
                 1411.8 
                 (M − H)− 
               
               
                 1632 
                 SSC-TFA-07 
                 1.428 
                 1298.7 
                 (M + H)+ 
               
               
                 1633 
                 SSC-TFA-07 
                 1.487 
                 1382.6 
                 (M + H)+ 
               
               
                 1634 
                 SSC-AF-00 
                 2.100 
                 1310.5 
                 (M − H)− 
               
               
                 1635 
                 SSC-TFA-07 
                 1.469 
                 1368.6 
                 (M + H)+ 
               
               
                 1636 
                 SSC-TFA-07 
                 1.469 
                 1429.6 
                 (M + H)+ 
               
               
                 1637 
                 SSC-TFA-07 
                 1.500 
                 1382.6 
                 (M + H)+ 
               
               
                 1638 
                 SSC-AF-00 
                 2.143 
                 1397.8 
                 (M − H)− 
               
               
                 1639 
                 SSC-TFA-07 
                 1.513 
                 1413.7 
                 (M + H)+ 
               
               
                 1640 
                 SSC-TFA-07 
                 1.519 
                 1479.8 
                 (M + H)+ 
               
               
                 1641 
                 SSC-TFA-07 
                 1.511 
                 1479.7 
                 (M + H)+ 
               
               
                 1642 
                 SSC-TFA-07 
                 1.663 
                 1467.8 
                 (M + H)+ 
               
               
                 1643 
                 SSC-TFA-07 
                 1.496 
                 1473.7 
                 (M + H)+ 
               
               
                 1644 
                 SSC-FA-03 
                 2.124 
                 1454.0 
                 (M − H)− 
               
               
                 1645 
                 SSC-AF-00 
                 2.101 
                 1433.8 
                 (M − H)− 
               
               
                 1646 
                 SSC-FA-03 
                 1.849 
                 1401.5 
                 (M − H)− 
               
               
                 1647 
                 SSC-AF-00 
                 2.120 
                 1421.9 
                 (M − H)− 
               
               
                 1648 
                 SSC-AF-00 
                 2.136 
                 1315.0 
                 (M − H)− 
               
               
                 1649 
                 SSC-AF-00 
                 2.131 
                 1421.9 
                 (M − H)− 
               
               
                 1650 
                 SSC-AF-00 
                 2.216 
                 1440.0 
                 (M − H)− 
               
               
                 1651 
                 SSC-FA-03 
                 2.100 
                 1453.8 
                 (M − H)− 
               
               
                 1652 
                 SSC-FA-03 
                 1.947 
                 1399.8 
                 (M − H)− 
               
               
                 1653 
                 SSC-AF-00 
                 2.029 
                 1393.8 
                 (M − H)− 
               
               
                 1654 
                 SSC-AF-00 
                 2.200 
                 1328.7 
                 (M − H)− 
               
               
                 1655 
                 SSC-FA-03 
                 1.755 
                 1272.8 
                 (M − H)− 
               
               
                 1656 
                 SSC-AF-00 
                 2.137 
                 1411.9 
                 (M − H)− 
               
               
                 1657 
                 SSC-FA-03 
                 1.988 
                 1439.9 
                 (M − H)− 
               
               
                 1658 
                 SSC-AF-00 
                 2.121 
                 1433.5 
                 (M − H)− 
               
               
                 1659 
                 SSC-FA-03 
                 1.844 
                 1385.8 
                 (M − H)− 
               
               
                 1660 
                 SSC-AF-00 
                 2.167 
                 1461.8 
                 (M − H)− 
               
               
                 1661 
                 SSC-AF-00 
                 2.139 
                 1336.5 
                 (M − H)− 
               
               
                 1662 
                 SSC-FA-03 
                 1.885 
                 1400.0 
                 (M − H)− 
               
               
                 1663 
                 SSC-FA-03 
                 2.127 
                 1465.9 
                 (M − H)− 
               
               
                 1664 
                 SSC-FA-03 
                 1.759 
                 1399.8 
                 (M − H)− 
               
               
                 1665 
                 SSC-FA-03 
                 1.821 
                 1411.7 
                 (M − H)− 
               
               
                 1666 
                 SSC-AF-00 
                 2.117 
                 1383.9 
                 (M − H)− 
               
               
                 1667 
                 SSC-AF-00 
                 2.084 
                 1312.4 
                 (M + H)+ 
               
               
                 1668 
                 SSC-AF-00 
                 2.232 
                 1455.8 
                 (M − H)− 
               
               
                 1669 
                 SSC-FA-03 
                 1.956 
                 1411.9 
                 (M − H)− 
               
               
                 1670 
                 SSC-AF-00 
                 2.105 
                 1397.8 
                 (M − H)− 
               
               
                 1671 
                 SSC-AF-00 
                 2.225 
                 1439.8 
                 (M − H)− 
               
               
                 1672 
                 SSC-FA-03 
                 1.920 
                 1412.0 
                 (M − H)− 
               
               
                 1673 
                 SSC-FA-03 
                 2.000 
                 1376.9 
                 (M − H)− 
               
               
                 1674 
                 SSC-FA-03 
                 1.731 
                 1343.6 
                 (M − H)− 
               
               
                 1675 
                 SSC-FA-03 
                 1.959 
                 1425.8 
                 (M − H)− 
               
               
                 1676 
                 SSC-AF-00 
                 2.165 
                 1408.0 
                 (M − H)− 
               
               
                 1677 
                 SSC-AF-00 
                 2.075 
                 1369.9 
                 (M − H)− 
               
               
                 1678 
                 SSC-AF-00 
                 2.160 
                 1411.9 
                 (M − H)− 
               
               
                 1679 
                 SSC-AF-00 
                 2.152 
                 1437.8 
                 (M − H)− 
               
               
                 1680 
                 SSC-FA-03 
                 1.956 
                 1413.9 
                 (M − H)− 
               
               
                 1681 
                 SSC-AF-00 
                 2.100 
                 1357.9 
                 (M − H)− 
               
               
                 1682 
                 SSC-FA-03 
                 1.957 
                 1350.9 
                 (M − H)− 
               
               
                 1683 
                 SSC-FA-03 
                 1.736 
                 1280.9 
                 (M − H)− 
               
               
                 1684 
                 SSC-FA-03 
                 1.831 
                 1385.8 
                 (M − H)− 
               
               
                 1685 
                 SSC-FA-03 
                 1.831 
                 1433.8 
                 (M − H)− 
               
               
                 1686 
                 SSC-AF-00 
                 2.159 
                 1399.9 
                 (M − H)− 
               
               
                 1687 
                 SSC-FA-03 
                 1.771 
                 1373.9 
                 (M − H)− 
               
               
                 1688 
                 SSC-FA-03 
                 1.852 
                 1287.0 
                 (M − H)− 
               
               
                 1689 
                 SSC-AF-00 
                 2.196 
                 1425.9 
                 (M − H)− 
               
               
                 1690 
                 SSC-AF-00 
                 2.179 
                 1454.0 
                 (M − H)− 
               
               
                 1691 
                 SSC-FA-03 
                 1.755 
                 1254.4 
                 (M − H)− 
               
               
                 1692 
                 SSC-FA-03 
                 2.107 
                 1454.0 
                 (M − H)− 
               
               
                 1693 
                 SSC-AF-00 
                 2.171 
                 1490.8 
                 (M − H)− 
               
               
                 1694 
                 SSC-FA-03 
                 1.904 
                 1336.9 
                 (M − H)− 
               
               
                 1695 
                 SSC-FA-03 
                 1.881 
                 1397.8 
                 (M − H)− 
               
               
                 1696 
                 SSC-FA-03 
                 1.937 
                 1399.5 
                 (M + H)+ 
               
               
                 1697 
                 SSC-FA-03 
                 2.021 
                 1440.0 
                 (M − H)− 
               
               
                 1698 
                 SSC-FA-03 
                 1.775 
                 1395.7 
                 (M − H)− 
               
               
                 1699 
                 SSC-AF-00 
                 2.087 
                 1371.9 
                 (M − H)− 
               
               
                 1700 
                 SSC-AF-00 
                 2.192 
                 1461.6 
                 (M − H)− 
               
               
                 1701 
                 SSC-AF-00 
                 2.180 
                 1465.9 
                 (M − H)− 
               
               
                 1702 
                 SSC-AF-00 
                 2.089 
                 1298.4 
                 (M − H)− 
               
               
                 1703 
                 SSC-FA-03 
                 1.491 
                 1476.8 
                 (M − H)− 
               
               
                 1704 
                 SSC-FA-03 
                 1.908 
                 1451.8 
                 (M − H)− 
               
               
                 1705 
                 SSC-FA-03 
                 2.009 
                 1439.9 
                 (M − H)− 
               
               
                 1706 
                 SSC-FA-03 
                 2.065 
                 1354.8 
                 (M − H)− 
               
               
                 1707 
                 SSC-FA-03 
                 2.044 
                 1453.8 
                 (M − H)− 
               
               
                 1708 
                 SSC-AF-00 
                 2.224 
                 1439.8 
                 (M − H)− 
               
               
                 1709 
                 SSC-AF-00 
                 2.152 
                 1399.6 
                 (M − H)− 
               
               
                 1710 
                 SSC-FA-03 
                 1.811 
                 1411.8 
                 (M − H)− 
               
               
                 1711 
                 SSC-AF-00 
                 2.097 
                 1386.0 
                 (M − H)− 
               
               
                 1712 
                 SSC-FA-03 
                 1.853 
                 1385.9 
                 (M − H)− 
               
               
                 1713 
                 SSC-AF-00 
                 2.169 
                 1413.9 
                 (M − H)− 
               
               
                 1714 
                 SSC-AF-00 
                 2.181 
                 1362.6 
                 (M − H)− 
               
               
                 1715 
                 SSC-AF-00 
                 2.123 
                 1383.9 
                 (M − H)− 
               
               
                 1716 
                 SSC-AF-00 
                 2.132 
                 1397.7 
                 (M − H)− 
               
               
                 1717 
                 SSC-AF-00 
                 2.187 
                 1354.8 
                 (M − H)− 
               
               
                 1718 
                 SSC-AF-00 
                 2.104 
                 1465.0 
                 (M − H)− 
               
               
                 1719 
                 SSC-AF-00 
                 2.201 
                 1427.9 
                 (M − H)− 
               
               
                 1720 
                 SSC-FA-03 
                 1.833 
                 1383.7 
                 (M − H)− 
               
               
                 1721 
                 SSC-FA-03 
                 1.701 
                 1359.5 
                 (M − H)− 
               
               
                 1722 
                 SSC-AF-00 
                 2.235 
                 1440.0 
                 (M − H)− 
               
               
                 1723 
                 SSC-AF-00 
                 2.232 
                 1440.0 
                 (M − H)− 
               
               
                 1724 
                 SSC-FA-03 
                 1.811 
                 1391.9 
                 (M − H)− 
               
               
                 1725 
                 SSC-AF-00 
                 2.111 
                 1421.8 
                 (M − H)− 
               
               
                 1726 
                 SSC-FA-03 
                 2.004 
                 1452.0 
                 (M − H)− 
               
               
                 1727 
                 SSC-AF-00 
                 2.164 
                 1447.7 
                 (M − H)− 
               
               
                 1728 
                 SSC-FA-03 
                 1.808 
                 1385.9 
                 (M − H)− 
               
               
                 1729 
                 SSC-AF-00 
                 2.149 
                 1399.9 
                 (M − H)− 
               
               
                 1730 
                 SSC-AF-00 
                 2.083 
                 1292.5 
                 (M − H)− 
               
               
                 1731 
                 SSC-AF-00 
                 2.139 
                 1413.9 
                 (M − H)− 
               
               
                 1732 
                 SSC-FA-03 
                 1.711 
                 1284.4 
                 (M − H)− 
               
               
                 1733 
                 SSC-FA-03 
                 2.021 
                 1342.7 
                 (M − H)− 
               
               
                 1734 
                 SSC-FA-03 
                 1.832 
                 1487.5 
                 (M − H)− 
               
               
                 1735 
                 SSC-AF-00 
                 2.269 
                 1454.0 
                 (M − H)− 
               
               
                 1736 
                 SSC-FA-03 
                 2.052 
                 1455.8 
                 (M − H)− 
               
               
                 1737 
                 SSC-AF-00 
                 2.101 
                 1371.8 
                 (M − H)− 
               
               
                 1738 
                 SSC-AF-00 
                 2.117 
                 1399.8 
                 (M − H)− 
               
               
                 1739 
                 SSC-FA-03 
                 1.901 
                 1412.0 
                 (M − H)− 
               
               
                 1740 
                 SSC-AF-00 
                 2.240 
                 1439.9 
                 (M − H)− 
               
               
                 1741 
                 SSC-AF-00 
                 2.133 
                 1385.9 
                 (M − H)− 
               
               
                 1742 
                 SSC-AF-00 
                 2.129 
                 1298.9 
                 (M − H)− 
               
               
                 1743 
                 SSC-FA-03 
                 1.871 
                 1371.6 
                 (M − H)− 
               
               
                 1744 
                 SSC-FA-03 
                 2.020 
                 1465.9 
                 (M − H)− 
               
               
                 1745 
                 SSC-AF-00 
                 2.151 
                 1507.0 
                 (M − H)− 
               
               
                 1746 
                 SSC-FA-03 
                 2.087 
                 1451.8 
                 (M − H)− 
               
               
                 1747 
                 SSC-FA-03 
                 1.951 
                 1362.9 
                 (M − H)− 
               
               
                 1748 
                 SSC-FA-03 
                 1.865 
                 1444.0 
                 (M − H)− 
               
               
                 1749 
                 SSC-FA-03 
                 1.745 
                 1393.8 
                 (M − H)− 
               
               
                 1750 
                 SSC-AF-00 
                 2.141 
                 1362.6 
                 (M − H)− 
               
               
                 1751 
                 SSC-FA-03 
                 1.873 
                 1401.5 
                 (M + H)+ 
               
               
                 1752 
                 SSC-FA-03 
                 1.764 
                 1357.8 
                 (M − H)− 
               
               
                 1753 
                 SSC-FA-03 
                 1.787 
                 1377.6 
                 (M − H)− 
               
               
                 1754 
                 SSC-FA-03 
                 1.972 
                 1425.9 
                 (M − H)− 
               
               
                 1755 
                 SSC-AF-00 
                 2.084 
                 1383.9 
                 (M − H)− 
               
               
                 1756 
                 SSC-AF-00 
                 2.076 
                 1419.9 
                 (M − H)− 
               
               
                 1757 
                 SSC-FA-03 
                 1.937 
                 1425.8 
                 (M − H)− 
               
               
                 1758 
                 SSC-FA-03 
                 1.731 
                 1413.9 
                 (M − H)− 
               
               
                 1759 
                 SSC-FA-03 
                 2.056 
                 1452.0 
                 (M − H)− 
               
               
                 1760 
                 SSC-AF-00 
                 2.148 
                 1397.9 
                 (M − H)− 
               
               
                 1761 
                 SSC-AF-00 
                 2.077 
                 1419.9 
                 (M − H)− 
               
               
                 1762 
                 SSC-AF-00 
                 2.081 
                 1407.7 
                 (M − H)− 
               
               
                 1763 
                 SSC-FA-03 
                 1.920 
                 1441.5 
                 (M − H)− 
               
               
                 1764 
                 SSC-FA-03 
                 1.889 
                 1439.9 
                 (M − H)− 
               
               
                 1765 
                 SSC-AF-00 
                 2.135 
                 1499.7 
                 (M − H)− 
               
               
                 1766 
                 SSC-AF-00 
                 2.211 
                 1453.9 
                 (M − H)− 
               
               
                 1767 
                 SSC-AF-00 
                 2.169 
                 1412.0 
                 (M − H)− 
               
               
                 1768 
                 SSC-FA-03 
                 1.751 
                 1399.8 
                 (M − H)− 
               
               
                 1769 
                 SSC-AF-00 
                 2.079 
                 1407.8 
                 (M − H)− 
               
               
                 1770 
                 SSC-AF-00 
                 2.196 
                 1411.9 
                 (M − H)− 
               
               
                 1771 
                 SSC-FA-03 
                 1.919 
                 1429.8 
                 (M − H)− 
               
               
                 1772 
                 SSC-AF-00 
                 2.152 
                 1459.6 
                 (M − H)− 
               
               
                 1773 
                 SSC-AF-00 
                 2.165 
                 1300.5 
                 (M − H)− 
               
               
                 1774 
                 SSC-AF-00 
                 2.113 
                 1310.9 
                 (M − H)− 
               
               
                 1775 
                 SSC-AF-00 
                 2.183 
                 1412.0 
                 (M − H)− 
               
               
                 1776 
                 SSC-FA-03 
                 2.048 
                 1453.8 
                 (M − H)− 
               
               
                 1777 
                 SSC-AF-00 
                 2.125 
                 1411.8 
                 (M − H)− 
               
               
                 1778 
                 SSC-FA-03 
                 1.737 
                 1268.4 
                 (M + H)+ 
               
               
                 1779 
                 SSC-FA-03 
                 1.761 
                 1393.8 
                 (M − H)− 
               
               
                 1780 
                 SSC-FA-03 
                 1.812 
                 1383.9 
                 (M − H)− 
               
               
                 1781 
                 SSC-FA-03 
                 1.899 
                 1425.8 
                 (M − H)− 
               
               
                 1782 
                 SSC-AF-00 
                 2.135 
                 1436.0 
                 (M − H)− 
               
               
                 1783 
                 SSC-AF-00 
                 2.133 
                 1282.5 
                 (M + H)+ 
               
               
                 1784 
                 SSC-FA-03 
                 1.923 
                 1300.6 
                 (M − H)− 
               
               
                 1785 
                 SSC-AF-00 
                 2.136 
                 1459.8 
                 (M − H)− 
               
               
                 1786 
                 SSC-FA-03 
                 2.016 
                 1453.9 
                 (M − H)− 
               
               
                 1787 
                 SSC-FA-03 
                 2.020 
                 1451.8 
                 (M − H)− 
               
               
                 1788 
                 SSC-FA-03 
                 1.741 
                 1399.5 
                 (M − H)− 
               
               
                 1789 
                 SSC-AF-00 
                 2.183 
                 1346.9 
                 (M − H)− 
               
               
                 1790 
                 SSC-FA-03 
                 1.807 
                 1407.8 
                 (M − H)− 
               
               
                 1791 
                 SSC-AF-00 
                 2.157 
                 1411.9 
                 (M − H)− 
               
               
                 1792 
                 SSC-AF-00 
                 2.100 
                 1324.5 
                 (M − H)− 
               
               
                 1793 
                 SSC-FA-03 
                 1.912 
                 1350.6 
                 (M − H)− 
               
               
                 1794 
                 SSC-FA-03 
                 1.845 
                 1411.9 
                 (M − H)− 
               
               
                 1795 
                 SSC-AF-00 
                 2.188 
                 1474.0 
                 (M − H)− 
               
               
                 1796 
                 SSC-FA-03 
                 1.971 
                 1423.9 
                 (M − H)− 
               
               
                 1797 
                 SSC-AF-00 
                 2.132 
                 1447.7 
                 (M − H)− 
               
               
                 1798 
                 SSC-FA-03 
                 2.017 
                 1425.9 
                 (M − H)− 
               
               
                 1799 
                 SSC-AF-00 
                 2.161 
                 1413.9 
                 (M − H)− 
               
               
                 1800 
                 SSC-AF-00 
                 2.168 
                 1328.5 
                 (M − H)− 
               
               
                 1801 
                 SSC-FA-03 
                 1.836 
                 1322.9 
                 (M − H)− 
               
               
                 1802 
                 SSC-FA-03 
                 1.952 
                 1397.6 
                 (M − H)− 
               
               
                 1803 
                 SSC-AF-00 
                 2.120 
                 1385.9 
                 (M − H)− 
               
               
                 1804 
                 SSC-AF-00 
                 2.157 
                 1447.9 
                 (M − H)− 
               
               
                 1805 
                 SSC-FA-03 
                 1.923 
                 1415.9 
                 (M − H)− 
               
               
                 1806 
                 SSC-FA-03 
                 1.801 
                 1391.8 
                 (M − H)− 
               
               
                 1807 
                 SSC-FA-03 
                 2.015 
                 1425.9 
                 (M − H)− 
               
               
                 1808 
                 SSC-FA-03 
                 1.880 
                 1301.0 
                 (M − H)− 
               
               
                 1809 
                 SSC-FA-03 
                 1.856 
                 1336.9 
                 (M − H)− 
               
               
                 1810 
                 SSC-AF-00 
                 2.116 
                 1460.8 
                 (M − H)− 
               
               
                 1811 
                 SSC-AF-00 
                 2.172 
                 1439.8 
                 (M − H)− 
               
               
                 1812 
                 SSC-AF-00 
                 2.079 
                 1359.5 
                 (M − H)− 
               
               
                 1813 
                 SSC-AF-00 
                 2.228 
                 1368.9 
                 (M − H)− 
               
               
                 1814 
                 SSC-AF-00 
                 2.131 
                 1399.9 
                 (M − H)− 
               
               
                 1815 
                 SSC-FA-03 
                 1.940 
                 1413.8 
                 (M − H)− 
               
               
                 1816 
                 SSC-AF-00 
                 2.105 
                 1409.7 
                 (M − H)− 
               
               
                 1817 
                 SSC-AF-00 
                 2.179 
                 1411.7 
                 (M − H)− 
               
               
                 1818 
                 SSC-AF-00 
                 2.124 
                 1411.8 
                 (M − H)− 
               
               
                 1819 
                 SSC-FA-03 
                 1.936 
                 1439.7 
                 (M − H)− 
               
               
                 1820 
                 SSC-AF-00 
                 2.251 
                 1465.8 
                 (M − H)− 
               
               
                 1821 
                 SSC-AF-00 
                 2.205 
                 1425.9 
                 (M − H)− 
               
               
                 1822 
                 SSC-FA-03 
                 1.885 
                 1424.0 
                 (M − H)− 
               
               
                 1823 
                 SSC-FA-03 
                 1.972 
                 1426.0 
                 (M − H)− 
               
               
                 1824 
                 SSC-FA-03 
                 2.063 
                 1451.9 
                 (M − H)− 
               
               
                 1825 
                 SSC-FA-03 
                 1.843 
                 1397.5 
                 (M − H)− 
               
               
                 1826 
                 SSC-AF-00 
                 2.231 
                 1439.8 
                 (M − H)− 
               
               
                 1827 
                 SSC-FA-03 
                 1.809 
                 1383.9 
                 (M − H)− 
               
               
                 1828 
                 SSC-AF-00 
                 2.111 
                 1434.0 
                 (M − H)− 
               
               
                 1829 
                 SSC-FA-03 
                 1.900 
                 1385.9 
                 (M − H)− 
               
               
                 1830 
                 SSC-FA-03 
                 1.992 
                 1414.0 
                 (M − H)− 
               
               
                 1831 
                 SSC-FA-03 
                 1.935 
                 1441.9 
                 (M − H)− 
               
               
                 1832 
                 SSC-FA-03 
                 1.955 
                 1399.9 
                 (M − H)− 
               
               
                 1833 
                 SSC-AF-00 
                 2.212 
                 1439.9 
                 (M − H)− 
               
               
                 1834 
                 SSC-FA-03 
                 1.627 
                 1448.8 
                 (M − H)− 
               
               
                 1835 
                 SSC-AF-00 
                 2.236 
                 1451.9 
                 (M − H)− 
               
               
                 1836 
                 SSC-FA-03 
                 1.779 
                 1381.6 
                 (M − H)− 
               
               
                 1837 
                 SSC-FA-03 
                 1.760 
                 1399.5 
                 (M − H)− 
               
               
                 1838 
                 SSC-FA-03 
                 2.095 
                 1465.6 
                 (M − H)− 
               
               
                 1839 
                 SSC-AF-00 
                 2.121 
                 1403.9 
                 (M − H)− 
               
               
                 1840 
                 SSC-AF-00 
                 2.101 
                 1445.9 
                 (M − H)− 
               
               
                 1841 
                 SSC-AF-00 
                 2.136 
                 1425.8 
                 (M − H)− 
               
               
                 1842 
                 SSC-AF-00 
                 2.085 
                 1407.9 
                 (M − H)− 
               
               
                 1843 
                 SSC-AF-00 
                 2.163 
                 1425.9 
                 (M − H)− 
               
               
                 1844 
                 SSC-AF-00 
                 2.091 
                 1365.9 
                 (M − H)− 
               
               
                 1845 
                 SSC-AF-00 
                 2.176 
                 1411.9 
                 (M − H)− 
               
               
                 1846 
                 SSC-AF-00 
                 2.196 
                 1413.6 
                 (M − H)− 
               
               
                 1847 
                 SSC-FA-03 
                 1.800 
                 1399.8 
                 (M − H)− 
               
               
                 1848 
                 SSC-AF-00 
                 2.071 
                 1387.9 
                 (M − H)− 
               
               
                 1849 
                 SSC-AF-00 
                 2.201 
                 1407.8 
                 (M − H)− 
               
               
                 1850 
                 SSC-FA-03 
                 1.904 
                 1433.7 
                 (M − H)− 
               
               
                 1851 
                 SSC-FA-03 
                 1.948 
                 1360.9 
                 (M − H)− 
               
               
                 1852 
                 SSC-AF-00 
                 2.137 
                 1460.0 
                 (M − H)− 
               
               
                 1853 
                 SSC-AF-00 
                 2.099 
                 1409.5 
                 (M − H)− 
               
               
                 1854 
                 SSC-FA-03 
                 1.911 
                 1399.5 
                 (M − H)− 
               
               
                 1855 
                 SSC-FA-03 
                 1.957 
                 1455.8 
                 (M − H)− 
               
               
                 1856 
                 SSC-AF-00 
                 2.148 
                 1336.6 
                 (M − H)− 
               
               
                 1857 
                 SSC-FA-03 
                 1.877 
                 1429.7 
                 (M + H)+ 
               
               
                 1858 
                 SSC-AF-00 
                 2.131 
                 1399.9 
                 (M − H)− 
               
               
                 1859 
                 SSC-FA-03 
                 1.985 
                 1439.8 
                 (M − H)− 
               
               
                 1860 
                 SSC-AF-00 
                 2.223 
                 1451.8 
                 (M − H)− 
               
               
                 1861 
                 SSC-AF-00 
                 2.259 
                 1454.0 
                 (M − H)− 
               
               
                 1862 
                 SSC-FA-03 
                 1.980 
                 1424.0 
                 (M − H)− 
               
               
                 1863 
                 SSC-FA-03 
                 1.953 
                 1425.8 
                 (M − H)− 
               
               
                 1864 
                 SSC-AF-00 
                 2.187 
                 1451.5 
                 (M − H)− 
               
               
                 1865 
                 SSC-AF-00 
                 2.097 
                 1373.9 
                 (M − H)− 
               
               
                 1866 
                 SSC-FA-03 
                 1.737 
                 1420.0 
                 (M − H)− 
               
               
                 1867 
                 SSC-AF-00 
                 2.024 
                 1367.8 
                 (M − H)− 
               
               
                 1868 
                 SSC-AF-00 
                 2.172 
                 1437.8 
                 (M − H)− 
               
               
                 1869 
                 SSC-FA-03 
                 1.871 
                 1475.8 
                 (M − H)− 
               
               
                 1870 
                 SSC-AF-00 
                 2.140 
                 1410.0 
                 (M − H)− 
               
               
                 1871 
                 SSC-AF-00 
                 2.101 
                 1435.7 
                 (M − H)− 
               
               
                 1872 
                 SSC-FA-03 
                 1.817 
                 1449.6 
                 (M − H)− 
               
               
                 1873 
                 SSC-A-FA-01 
                 6.407 
                 1549.7 
                 (M − H)− 
               
               
                 1874 
                 SSC-A-AF-01 
                 8.385 
                 1427.0 
                 (M − H)− 
               
               
                 1875 
                 SSC-AF-00 
                 2.139 
                 1428.0 
                 (M − H)− 
               
               
                 1876 
                 SSC-A-FA-01 
                 6.835 
                 1531.7 
                 (M + H)+ 
               
               
                 1877 
                 SSC-FA-03 
                 1.836 
                 1425.6 
                 (M − H)− 
               
               
                 1878 
                 SSC-A-FA-01 
                 5.625 
                 1467.7 
                 (M + H)+ 
               
               
                 1879 
                 SSC-FA-03 
                 1.924 
                 1465.6 
                 (M − H)− 
               
               
                 1880 
                 SSC-AF-00 
                 2.231 
                 1490.0 
                 (M − H)− 
               
               
                 1881 
                 SSC-FA-03 
                 1.537 
                 1491.0 
                 (M − H)− 
               
               
                 1882 
                 SSC-A-AF-01 
                 7.781 
                 1546.1 
                 (M − H)− 
               
               
                 1883 
                 SSC-A-FA-01 
                 6.135 
                 1364.6 
                 (M + H)+ 
               
               
                 1884 
                 SSC-AF-00 
                 2.092 
                 1475.7 
                 (M − H)− 
               
               
                 1885 
                 SSC-A-AF-01 
                 7.835 
                 1487.7 
                 (M − H)− 
               
               
                 1886 
                 SSC-FA-03 
                 1.516 
                 1486.8 
                 (M − H)− 
               
               
                 1887 
                 SSC-A-FA-01 
                 6.040 
                 1473.7 
                 (M + H)+ 
               
               
                 1888 
                 SSC-A-FA-01 
                 6.519 
                 1598.0 
                 (M − H)− 
               
               
                 1889 
                 SSC-A-FA-01 
                 5.489 
                 1431.6 
                 (M + H)+ 
               
               
                 1890 
                 SSC-AF-00 
                 2.101 
                 1459.7 
                 (M − H)− 
               
               
                 1891 
                 SSC-A-AF-01 
                 8.248 
                 1380.6 
                 (M − H)− 
               
               
                 1892 
                 SSC-AF-00 
                 2.144 
                 1490.8 
                 (M − H)− 
               
               
                 1893 
                 SSC-A-FA-01 
                 5.875 
                 1509.7 
                 (M + H)+ 
               
               
                 1894 
                 SSC-FA-03 
                 1.919 
                 1411.8 
                 (M − H)− 
               
               
                 1895 
                 SSC-A-FA-01 
                 6.648 
                 1513.8 
                 (M − H)− 
               
               
                 1896 
                 SSC-AF-00 
                 2.049 
                 1389.9 
                 (M − H)− 
               
               
                 1897 
                 SSC-AF-00 
                 2.061 
                 1460.8 
                 (M − H)− 
               
               
                 1898 
                 SSC-FA-03 
                 1.879 
                 1459.8 
                 (M − H)− 
               
               
                 1899 
                 SSC-A-AF-01 
                 8.316 
                 1432.5 
                 (M − H)− 
               
               
                 1900 
                 SSC-FA-03 
                 1.807 
                 1443.6 
                 (M − H)− 
               
               
                 1901 
                 SSC-AF-00 
                 2.169 
                 1440.0 
                 (M − H)− 
               
               
                 1902 
                 SSC-A-FA-01 
                 6.504 
                 1555.9 
                 (M − H)− 
               
               
                 1903 
                 SSC-A-FA-01 
                 5.531 
                 1461.6 
                 (M + H)+ 
               
               
                 1904 
                 SSC-AF-00 
                 2.080 
                 1421.7 
                 (M − H)− 
               
               
                 1905 
                 SSC-FA-03 
                 1.801 
                 1405.8 
                 (M − H)− 
               
               
                 1906 
                 SSC-AF-00 
                 2.156 
                 1439.8 
                 (M − H)− 
               
               
                 1907 
                 SSC-FA-03 
                 1.956 
                 1463.9 
                 (M − H)− 
               
               
                 1908 
                 SSC-FA-03 
                 1.877 
                 1427.8 
                 (M − H)− 
               
               
                 1909 
                 SSC-A-AF-01 
                 7.932 
                 1471.6 
                 (M − H)− 
               
               
                 1910 
                 SSC-A-FA-01 
                 6.503 
                 1597.8 
                 (M − H)− 
               
               
                 1911 
                 SSC-FA-03 
                 1.779 
                 1466.8 
                 (M − H)− 
               
               
                 1912 
                 SSC-A-FA-01 
                 6.449 
                 1378.7 
                 (M + H)+ 
               
               
                 1913 
                 SSC-AF-00 
                 2.131 
                 1476.8 
                 (M − H)− 
               
               
                 1914 
                 SSC-A-FA-01 
                 5.473 
                 1450.0 
                 (M − H)− 
               
               
                 1915 
                 SSC-FA-03 
                 1.841 
                 1413.6 
                 (M − H)− 
               
               
                 1916 
                 SSC-FA-03 
                 1.868 
                 1439.8 
                 (M − H)− 
               
               
                 1917 
                 SSC-FA-03 
                 1.500 
                 1436.9 
                 (M − H)− 
               
               
                 1918 
                 SSC-A-AF-01 
                 8.237 
                 1436.6 
                 (M + H)+ 
               
               
                 1919 
                 SSC-A-FA-01 
                 6.120 
                 1392.6 
                 (M + H)+ 
               
               
                 1920 
                 SSC-A-FA-01 
                 5.977 
                 1515.6 
                 (M + H)+ 
               
               
                 1921 
                 SSC-FA-03 
                 1.852 
                 1470.8 
                 (M − H)− 
               
               
                 1922 
                 SSC-A-FA-01 
                 5.559 
                 1459.9 
                 (M − H)− 
               
               
                 1923 
                 SSC-FA-03 
                 1.849 
                 1427.8 
                 (M − H)− 
               
               
                 1924 
                 SSC-FA-03 
                 1.965 
                 1485.8 
                 (M − H)− 
               
               
                 1925 
                 SSC-FA-03 
                 1.912 
                 1411.8 
                 (M − H)− 
               
               
                 1926 
                 SSC-AF-00 
                 2.191 
                 1526.0 
                 (M − H)− 
               
               
                 1927 
                 SSC-A-FA-01 
                 5.764 
                 1497.1 
                 (M − H)− 
               
               
                 1928 
                 SSC-FA-03 
                 1.923 
                 1453.6 
                 (M − H)− 
               
               
                 1929 
                 SSC-FA-03 
                 1.745 
                 1373.9 
                 (M − H)− 
               
               
                 1930 
                 SSC-AF-00 
                 2.139 
                 1522.0 
                 (M − H)− 
               
               
                 1931 
                 SSC-FA-03 
                 1.831 
                 1383.9 
                 (M − H)− 
               
               
                 1932 
                 SSC-FA-03 
                 1.904 
                 1529.8 
                 (M − H)− 
               
               
                 1933 
                 SSC-FA-03 
                 1.924 
                 1453.8 
                 (M − H)− 
               
               
                 1934 
                 SSC-FA-03 
                 1.796 
                 1401.9 
                 (M − H)− 
               
               
                 1935 
                 SSC-A-AF-01 
                 7.776 
                 1501.9 
                 (M − H)− 
               
               
                 1936 
                 SSC-FA-03 
                 1.913 
                 1454.0 
                 (M − H)− 
               
               
                 1937 
                 SSC-AF-00 
                 2.104 
                 1479.0 
                 (M − H)− 
               
               
                 1938 
                 SSC-AF-00 
                 2.169 
                 1441.8 
                 (M − H)− 
               
               
                 1939 
                 SSC-AF-00 
                 2.141 
                 1391.6 
                 (M − H)− 
               
               
                 1940 
                 SSC-AF-00 
                 2.163 
                 1434.2 
                 (M − H)− 
               
               
                 1941 
                 SSC-AF-00 
                 2.135 
                 1373.6 
                 (M − H)− 
               
               
                 1942 
                 SSC-A-FA-01 
                 6.349 
                 1525.6 
                 (M + H)+ 
               
               
                 1943 
                 SSC-A-FA-01 
                 6.147 
                 1507.5 
                 (M − H)− 
               
               
                 1944 
                 SSC-A-FA-01 
                 5.992 
                 1557.6 
                 (M + H)+ 
               
               
                 1945 
                 SSC-A-FA-01 
                 6.043 
                 1515.6 
                 (M + H)+ 
               
               
                 1946 
                 SSC-AF-00 
                 2.117 
                 1462.8 
                 (M − H)− 
               
               
                 1947 
                 SSC-FA-03 
                 1.851 
                 1408.2 
                 (M − H)− 
               
               
                 1948 
                 SSC-FA-03 
                 1.847 
                 1503.9 
                 (M − H)− 
               
               
                 1949 
                 SSC-FA-03 
                 1.733 
                 1403.5 
                 (M − H)− 
               
               
                 1950 
                 SSC-A-AF-02 
                 7.981 
                 1399.8 
                 (M − H)− 
               
               
                 1951 
                 SSC-A-AF-01 
                 7.521 
                 1501.9 
                 (M − H)− 
               
               
                 1952 
                 SSC-A-FA-01 
                 6.000 
                 1492.0 
                 (M − H)− 
               
               
                 1953 
                 SSC-A-AF-01 
                 7.695 
                 1555.6 
                 (M − H)− 
               
               
                 1954 
                 SSC-FA-03 
                 1.836 
                 1427.8 
                 (M − H)− 
               
               
                 1955 
                 SSC-AF-00 
                 2.204 
                 1546.8 
                 (M − H)− 
               
               
                 1956 
                 SSC-FA-03 
                 1.741 
                 1415.8 
                 (M − H)− 
               
               
                 1957 
                 SSC-FA-03 
                 1.908 
                 1452.0 
                 (M − H)− 
               
               
                 1958 
                 SSC-AF-00 
                 2.145 
                 1397.6 
                 (M − H)− 
               
               
                 1959 
                 SSC-A-AF-01 
                 7.092 
                 1454.7 
                 (M − H)− 
               
               
                 1960 
                 SSC-A-FA-01 
                 5.577 
                 1465.6 
                 (M − H)− 
               
               
                 1961 
                 SSC-A-FA-01 
                 4.977 
                 1359.6 
                 (M + H)+ 
               
               
                 1962 
                 SSC-FA-03 
                 1.501 
                 1472.9 
                 (M − H)− 
               
               
                 1963 
                 SSC-AF-00 
                 2.123 
                 1448.0 
                 (M − H)− 
               
               
                 1964 
                 SSC-A-FA-01 
                 6.416 
                 1549.6 
                 (M − H)− 
               
               
                 1965 
                 SSC-FA-03 
                 1.860 
                 1426.1 
                 (M − H)− 
               
               
                 1966 
                 SSC-FA-03 
                 1.760 
                 1418.0 
                 (M − H)− 
               
               
                 1967 
                 SSC-A-FA-01 
                 5.724 
                 1360.5 
                 (M − H)− 
               
               
                 1968 
                 SSC-AF-00 
                 2.148 
                 1358.0 
                 (M − H)− 
               
               
                 1969 
                 SSC-FA-03 
                 1.895 
                 1411.8 
                 (M − H)− 
               
               
                 1970 
                 SSC-A-AF-01 
                 8.021 
                 1556.1 
                 (M − H)− 
               
               
                 1971 
                 SSC-AF-00 
                 2.109 
                 1429.7 
                 (M − H)− 
               
               
                 1972 
                 SSC-AF-00 
                 2.107 
                 1489.9 
                 (M − H)− 
               
               
                 1973 
                 SSC-AF-00 
                 2.045 
                 1432.7 
                 (M − H)− 
               
               
                 1974 
                 SSC-A-AF-01 
                 8.269 
                 1392.7 
                 (M − H)− 
               
               
                 1975 
                 SSC-AF-00 
                 2.128 
                 1397.6 
                 (M − H)− 
               
               
                 1976 
                 SSC-FA-03 
                 1.905 
                 1454.0 
                 (M − H)− 
               
               
                 1977 
                 SSC-FA-03 
                 1.941 
                 1512.0 
                 (M − H)− 
               
               
                 1978 
                 SSC-AF-00 
                 2.131 
                 1487.9 
                 (M − H)− 
               
               
                 1979 
                 SSC-AF-00 
                 2.131 
                 1415.8 
                 (M − H)− 
               
               
                 1980 
                 SSC-FA-03 
                 1.871 
                 1542.8 
                 (M − H)− 
               
               
                 1981 
                 SSC-A-FA-01 
                 5.297 
                 1456.6 
                 (M + H)+ 
               
               
                 1982 
                 SSC-FA-03 
                 1.548 
                 1464.8 
                 (M − H)− 
               
               
                 1983 
                 SSC-FA-03 
                 1.873 
                 1515.9 
                 (M − H)− 
               
               
                 1984 
                 SSC-AF-00 
                 2.116 
                 1473.7 
                 (M − H)− 
               
               
                 1985 
                 SSC-AF-00 
                 2.085 
                 1486.9 
                 (M − H)− 
               
               
                 1986 
                 SSC-A-FA-01 
                 5.824 
                 1505.6 
                 (M + H)+ 
               
               
                 1987 
                 SSC-A-FA-01 
                 6.361 
                 1545.7 
                 (M + H)+ 
               
               
                 1988 
                 SSC-AF-00 
                 2.160 
                 1423.8 
                 (M − H)− 
               
               
                 1989 
                 SSC-A-FA-01 
                 6.744 
                 1512.1 
                 (M − H)− 
               
               
                 1990 
                 SSC-FA-03 
                 1.896 
                 1485.6 
                 (M − H)− 
               
               
                 1991 
                 SSC-A-AF-01 
                 7.800 
                 1501.7 
                 (M − H)− 
               
               
                 1992 
                 SSC-A-FA-01 
                 6.268 
                 1527.6 
                 (M + H)+ 
               
               
                 1993 
                 SSC-FA-03 
                 1.841 
                 1501.9 
                 (M − H)− 
               
               
                 1994 
                 SSC-FA-03 
                 1.840 
                 1461.8 
                 (M − H)− 
               
               
                 1995 
                 SSC-A-AF-01 
                 8.312 
                 1379.0 
                 (M − H)− 
               
               
                 1996 
                 SSC-AF-00 
                 2.148 
                 1427.8 
                 (M − H)− 
               
               
                 1997 
                 SSC-A-AF-01 
                 7.956 
                 1469.6 
                 (M − H)− 
               
               
                 1998 
                 SSC-AF-00 
                 2.115 
                 1413.9 
                 (M − H)− 
               
               
                 1999 
                 SSC-FA-03 
                 1.789 
                 1399.5 
                 (M − H)− 
               
               
                 2000 
                 SSC-A-FA-01 
                 5.895 
                 1509.5 
                 (M + H)+ 
               
               
                 2001 
                 SSC-FA-03 
                 1.908 
                 1411.8 
                 (M − H)− 
               
               
                 2002 
                 SSC-A-AF-01 
                 7.488 
                 1496.8 
                 (M − H)− 
               
               
                 2003 
                 SSC-A-AF-01 
                 7.715 
                 1362.6 
                 (M − H)− 
               
               
                 2004 
                 SSC-FA-03 
                 1.835 
                 1419.9 
                 (M − H)− 
               
               
                 2005 
                 SSC-FA-03 
                 1.775 
                 1387.6 
                 (M − H)− 
               
               
                 2006 
                 SSC-FA-03 
                 1.808 
                 1401.6 
                 (M − H)− 
               
               
                 2007 
                 SSC-A-FA-02 
                 6.119 
                 1465.7 
                 (M + H)+ 
               
               
                 2008 
                 SSC-A-FA-02 
                 5.992 
                 1443.7 
                 (M + H)+ 
               
               
                 2009 
                 SSC-FA-03 
                 1.867 
                 1298.5 
                 (M − H)− 
               
               
                 2010 
                 SSC-AF-00 
                 2.117 
                 1272.9 
                 (M − H)− 
               
               
                 2011 
                 SSC-A-FA-02 
                 5.859 
                 1463.5 
                 (M − H)− 
               
               
                 2012 
                 SSC-AF-00 
                 2.199 
                 1300.9 
                 (M − H)− 
               
               
                 2013 
                 SSC-FA-03 
                 1.796 
                 1284.5 
                 (M − H)− 
               
               
                 2014 
                 SSC-FA-03 
                 2.105 
                 1300.5 
                 (M − H)− 
               
               
                 2015 
                 SSC-FA-03 
                 2.127 
                 1368.7 
                 (M − H)− 
               
               
                 2016 
                 SSC-FA-03 
                 2.021 
                 1344.9 
                 (M − H)− 
               
               
                 2017 
                 SSC-FA-03 
                 2.012 
                 1328.9 
                 (M − H)− 
               
               
                 2018 
                 SSC-AF-00 
                 2.241 
                 1328.6 
                 (M − H)− 
               
               
                 2019 
                 SSC-FA-03 
                 2.019 
                 1362.9 
                 (M − H)− 
               
               
                 2020 
                 SSC-A-FA-02 
                 5.791 
                 1457.6 
                 (M − H)− 
               
               
                 2021 
                 SSC-A-AF-01 
                 8.403 
                 1560.9 
                 (M − H)− 
               
               
                 2022 
                 SSC-A-AF-01 
                 8.377 
                 1546.9 
                 (M − H)− 
               
               
                 2023 
                 SSC-A-AF-01 
                 7.795 
                 1487.9 
                 (M − H)− 
               
               
                 2024 
                 SSC-A-FA-01 
                 7.003 
                 1526.0 
                 (M − H)− 
               
               
                 2025 
                 SSC-A-FA-01 
                 6.751 
                 1501.8 
                 (M − H)− 
               
               
                 2026 
                 SSC-A-AF-01 
                 8.057 
                 1491.0 
                 (M − H)− 
               
               
                 2027 
                 SSC-A-FA-01 
                 5.683 
                 1396.6 
                 (M + H)+ 
               
               
                 2028 
                 SSC-A-FA-01 
                 5.761 
                 1477.8 
                 (M + H)+ 
               
               
                 2029 
                 SSC-A-AF-01 
                 8.036 
                 1504.9 
                 (M − H)− 
               
               
                 2030 
                 SSC-AF-00 
                 2.200 
                 1495.9 
                 (M − H)− 
               
               
                 2031 
                 SSC-FA-03 
                 1.979 
                 1469.8 
                 (M − H)− 
               
               
                 2032 
                 SSC-A-AF-01 
                 8.084 
                 1504.9 
                 (M − H)− 
               
               
                 2033 
                 SSC-A-AF-01 
                 7.992 
                 1491.0 
                 (M − H)− 
               
               
                 2034 
                 SSC-A-FA-01 
                 5.313 
                 1485.8 
                 (M + H)+ 
               
               
                 2035 
                 SSC-FA-03 
                 2.117 
                 1529.9 
                 (M − H)− 
               
               
                 2036 
                 SSC-A-FA-01 
                 6.809 
                 1508.0 
                 (M − H)− 
               
               
                 2037 
                 SSC-A-FA-01 
                 6.308 
                 1443.9 
                 (M − H)− 
               
               
                 2038 
                 SSC-A-FA-01 
                 6.261 
                 1528.8 
                 (M − H)− 
               
               
                 2039 
                 SSC-A-AF-01 
                 7.985 
                 1381.7 
                 (M + H)+ 
               
               
                 2040 
                 SSC-A-AF-01 
                 7.727 
                 1345.6 
                 (M − H)− 
               
               
                 2041 
                 SSC-A-AF-01 
                 7.716 
                 1381.8 
                 (M + H)+ 
               
               
                 2042 
                 SSC-A-AF-01 
                 7.679 
                 1333.7 
                 (M + H)+ 
               
               
                 2043 
                 SSC-A-AF-01 
                 7.745 
                 1347.7 
                 (M + H)+ 
               
               
                 2044 
                 SSC-A-AF-01 
                 7.796 
                 1347.7 
                 (M + H)+ 
               
               
                 2045 
                 SSC-A-FA-01 
                 5.783 
                 1347.7 
                 (M + H)+ 
               
               
                 2046 
                 SSC-A-FA-01 
                 6.255 
                 1483.8 
                 (M − H)− 
               
               
                 2047 
                 SSC-A-AF-01 
                 8.128 
                 1499.8 
                 (M + H)+ 
               
               
                 2048 
                 SSC-AF-00 
                 2.244 
                 1525.9 
                 (M − H)− 
               
               
                 2049 
                 SSC-A-FA-01 
                 6.192 
                 1486.1 
                 (M − H)− 
               
               
                 2050 
                 SQDAA05 
                 0.89 
                 1595.3 
                 (M − H)− 
               
               
                 2051 
                 SSC-A-AF-01 
                 8.191 
                 1485.7 
                 (M + H)+ 
               
               
                 2052 
                 SSC-A-FA-01 
                 6.256 
                 1514.7 
                 (M + H)+ 
               
               
                 2053 
                 SSC-AF-00 
                 2.245 
                 1524.1 
                 (M − H)− 
               
               
                 2054 
                 SSC-A-AF-01 
                 8.000 
                 1511.1 
                 (M − H)− 
               
               
                 2055 
                 SSC-A-AF-01 
                 7.879 
                 1379.8 
                 (M + H)+ 
               
               
                 2056 
                 SQDFA50 
                 1.10 
                 1597.5 
                 (M − H)− 
               
               
                 2057 
                 SSC-AF-00 
                 2.235 
                 1467.7 
                 (M − H)− 
               
               
                 2058 
                 SSC-AF-00 
                 2.009 
                 1416.1 
                 (M − H)− 
               
               
                 2059 
                 SSC-AF-00 
                 2.267 
                 1397.7 
                 (M − H)− 
               
               
                 2060 
                 SSC-FA-03 
                 1.748 
                 1401.0 
                 (M − H)− 
               
               
                 2061 
                 SSC-AF-00 
                 2.119 
                 1353.6 
                 (M − H)− 
               
               
                 2062 
                 SSC-FA-03 
                 2.067 
                 1421.6 
                 (M − H)− 
               
               
                 2063 
                 SSC-AF-00 
                 2.155 
                 1389.6 
                 (M − H)− 
               
               
                 2064 
                 SSC-FA-03 
                 1.881 
                 1403.1 
                 (M − H)− 
               
               
                 2065 
                 SSC-FA-03 
                 1.908 
                 1403.2 
                 (M − H)− 
               
               
                 2066 
                 SSC-FA-03 
                 2.188 
                 1435.6 
                 (M − H)− 
               
               
                 2067 
                 SSC-FA-03 
                 2.003 
                 1451.7 
                 (M − H)− 
               
               
                 2068 
                 SSC-FA-03 
                 1.893 
                 1357.7 
                 (M − H)− 
               
               
                 2069 
                 SSC-AF-00 
                 2.140 
                 1419.0 
                 (M − H)− 
               
               
                 2070 
                 SSC-AF-00 
                 2.077 
                 1401.2 
                 (M − H)− 
               
               
                 2071 
                 SSC-FA-03 
                 1.756 
                 1350.5 
                 (M + H)+ 
               
               
                 2072 
                 SSC-AF-00 
                 2.131 
                 1443.0 
                 (M − H)− 
               
               
                 2073 
                 SSC-FA-03 
                 1.957 
                 1395.7 
                 (M − H)− 
               
               
                 2074 
                 SSC-FA-03 
                 1.977 
                 1430.0 
                 (M − H)− 
               
               
                 2075 
                 SSC-FA-03 
                 1.885 
                 1388.8 
                 (M − H)− 
               
               
                 2076 
                 SSC-FA-03 
                 1.881 
                 1434.0 
                 (M − H)− 
               
               
                 2077 
                 SSC-AF-00 
                 2.091 
                 1403.1 
                 (M + H)+ 
               
               
                 2078 
                 SSC-AF-00 
                 2.111 
                 1418.6 
                 (M − H)− 
               
               
                 2079 
                 SSC-FA-03 
                 1.927 
                 1381.8 
                 (M − H)− 
               
               
                 2080 
                 SSC-AF-00 
                 2.169 
                 1448.0 
                 (M − H)− 
               
               
                 2081 
                 SSC-AF-00 
                 2.193 
                 1393.8 
                 (M − H)− 
               
               
                 2082 
                 SSC-AF-00 
                 2.277 
                 1437.6 
                 (M + H)+ 
               
               
                 2083 
                 SSC-FA-03 
                 2.037 
                 1395.8 
                 (M − H)− 
               
               
                 2084 
                 SSC-FA-03 
                 1.755 
                 1381.0 
                 (M − H)− 
               
               
                 2085 
                 SSC-AF-00 
                 2.143 
                 1419.7 
                 (M + H)+ 
               
               
                 2086 
                 SQDFA05 
                 1.04 
                 1306.7 
                 (M + H)+ 
               
               
                 2087 
                 SQDFA05 
                 1.01 
                 1308.7 
                 (M + H)+ 
               
               
                 2088 
                 SQDFA05 
                 1.07 
                 1356.7 
                 (M + H)+ 
               
               
                 2089 
                 SQDFA05 
                 1.00 
                 1290.7 
                 (M + H)+ 
               
               
                 2090 
                 SQDFA05 
                 1.00 
                 1308.7 
                 (M + H)+ 
               
               
                 2091 
                 SQDFA05 
                 1.04 
                 1344.7 
                 (M + H)+ 
               
               
                 2092 
                 SQDFA05 
                 1.02 
                 1306.7 
                 (M + H)+ 
               
               
                 2093 
                 SQDFA05 
                 1.04 
                 1340.6 
                 (M + H)+ 
               
               
                 2094 
                 SQDFA05 
                 1.03 
                 1306.7 
                 (M + H)+ 
               
               
                 2095 
                 SQDFA05 
                 1.04 
                 1322.7 
                 (M + H)+ 
               
               
                 2096 
                 SSC-TFA-07 
                 1.363 
                 1407.7 
                 (M + H)+ 
               
               
                 2097 
                 SSC-A-FA-01 
                 5.915 
                 1497.1 
                 (M − H)− 
               
               
                 2098 
                 SSC-A-FA-01 
                 5.805 
                 1576.8 
                 (M + H)+ 
               
               
                 2099 
                 SSC-A-AF-01 
                 7.441 
                 1521.8 
                 (M − H)− 
               
               
                 2100 
                 SSC-A-FA-01 
                 5.575 
                 1494.6 
                 (M + H)+ 
               
               
                 2101 
                 SSC-A-FA-01 
                 5.523 
                 1523.6 
                 (M + H)+ 
               
               
                 2102 
                 SSC-A-FA-01 
                 5.717 
                 1484.7 
                 (M + H)+ 
               
               
                 2103 
                 SSC-A-FA-01 
                 5.472 
                 1540.9 
                 (M + H)+ 
               
               
                 2104 
                 SSC-A-AF-01 
                 7.816 
                 1553.0 
                 (M − H)− 
               
               
                 2105 
                 SSC-A-AF-01 
                 8.048 
                 1510.9 
                 (M − H)− 
               
               
                 2106 
                 SSC-A-AF-01 
                 7.720 
                 1472.7 
                 (M + H)+ 
               
               
                 2107 
                 SSC-A-FA-01 
                 5.476 
                 1570.7 
                 (M + H)+ 
               
               
                 2108 
                 SSC-A-FA-01 
                 5.508 
                 1528.7 
                 (M + H)+ 
               
               
                 2109 
                 SSC-A-FA-01 
                 5.720 
                 1513.1 
                 (M − H)− 
               
               
                 2110 
                 SSC-A-FA-01 
                 5.288 
                 1535.1 
                 (M − H)− 
               
               
                 2111 
                 SSC-A-FA-01 
                 5.409 
                 1512.8 
                 (M − H)− 
               
               
                 2112 
                 SSC-A-FA-01 
                 5.979 
                 1568.7 
                 (M + H)+ 
               
               
                 2113 
                 SSC-AF-00 
                 2.089 
                 1452.9 
                 (M − H)− 
               
               
                 2114 
                 SSC-FA-03 
                 1.861 
                 1483.8 
                 (M − H)− 
               
               
                 2115 
                 SSC-AF-00 
                 2.080 
                 1452.9 
                 (M − H)− 
               
               
                 2116 
                 SSC-TFA-07 
                 1.576 
                 1394.8 
                 (M + H)+ 
               
               
                 2117 
                 SSC-FA-03 
                 1.961 
                 1500.0 
                 (M − H)− 
               
               
                 2118 
                 SSC-TFA-07 
                 1.527 
                 1443.8 
                 (M + H)+ 
               
               
                 2119 
                 SSC-FA-03 
                 2.023 
                 1520.0 
                 (M − H)− 
               
               
                 2120 
                 SSC-FA-03 
                 1.819 
                 1546.9 
                 (M − H)− 
               
               
                 2121 
                 SSC-AF-00 
                 2.199 
                 1547.0 
                 (M − H)− 
               
               
                 2122 
                 SSC-FA-03 
                 1.927 
                 1499.9 
                 (M − H)− 
               
               
                 2123 
                 SSC-FA-03 
                 2.116 
                 1519.9 
                 (M − H)− 
               
               
                 2124 
                 SSC-FA-03 
                 2.105 
                 1552.0 
                 (M − H)− 
               
               
                 2125 
                 SSC-TFA-07 
                 1.640 
                 1519.8 
                 (M + H)+ 
               
               
                 2126 
                 SSC-TFA-07 
                 1.704 
                 1539.8 
                 (M + H)+ 
               
               
                 2127 
                 SSC-TFA-07 
                 1.580 
                 1443.8 
                 (M + H)+ 
               
               
                 2128 
                 SSC-TFA-07 
                 1.581 
                 1571.9 
                 (M + H)+ 
               
               
                 2129 
                 SSC-TFA-07 
                 1.700 
                 1539.9 
                 (M + H)+ 
               
               
                 2130 
                 SSC-TFA-07 
                 1.640 
                 1519.9 
                 (M + H)+ 
               
               
                 2131 
                 SSC-TFA-07 
                 1.588 
                 1535.9 
                 (M + H)+ 
               
               
                 2132 
                 SSC-TFA-07 
                 1.696 
                 1539.9 
                 (M + H)+ 
               
               
                 2133 
                 SSC-TFA-07 
                 1.640 
                 1540.0 
                 (M + H)+ 
               
               
                 2134 
                 SSC-TFA-07 
                 1.640 
                 1539.7 
                 (M + H)+ 
               
               
                 2135 
                 SSC-TFA-07 
                 1.611 
                 1571.9 
                 (M + H)+ 
               
               
                 2136 
                 SSC-TFA-07 
                 1.637 
                 1535.9 
                 (M + H)+ 
               
               
                 2137 
                 SSC-TFA-07 
                 1.692 
                 1519.8 
                 (M + H)+ 
               
               
                 2138 
                 SSC-TFA-07 
                 1.635 
                 1540.0 
                 (M + H)+ 
               
               
                 2139 
                 SSC-TFA-07 
                 1.632 
                 1519.9 
                 (M + H)+ 
               
               
                 2140 
                 SSC-TFA-07 
                 1.700 
                 1519.9 
                 (M + H)+ 
               
               
                 2141 
                 SSC-TFA-07 
                 1.704 
                 1519.9 
                 (M + H)+ 
               
               
                 2142 
                 SSC-AF-00 
                 2.084 
                 1339.6 
                 (M − H)− 
               
               
                 2143 
                 SSC-AF-00 
                 2.133 
                 1308.4 
                 (M − H)− 
               
               
                 2144 
                 SSC-AF-00 
                 2.069 
                 1379.5 
                 (M + H)+ 
               
               
                 2145 
                 SSC-FA-03 
                 1.812 
                 1296.5 
                 (M − H)− 
               
               
                 2146 
                 SSC-FA-03 
                 1.861 
                 1411.5 
                 (M − H)− 
               
               
                 2147 
                 SSC-FA-03 
                 1.873 
                 1411.5 
                 (M − H)− 
               
               
                 2148 
                 SSC-FA-03 
                 1.752 
                 1280.5 
                 (M − H)− 
               
               
                 2149 
                 SSC-FA-03 
                 1.893 
                 1411.7 
                 (M − H)− 
               
               
                 2150 
                 SSC-FA-03 
                 1.851 
                 1395.5 
                 (M + H)+ 
               
               
                 2151 
                 SSC-FA-03 
                 1.911 
                 1405.9 
                 (M − H)− 
               
               
                 2152 
                 SSC-A-FA-01 
                 5.337 
                 1302.6 
                 (M + H)+ 
               
               
                 2153 
                 SSC-A-AF-01 
                 7.408 
                 1288.7 
                 (M − H)− 
               
               
                 2154 
                 SSC-A-FA-01 
                 4.595 
                 1262.5 
                 (M + H)+ 
               
               
                 2155 
                 SSC-A-AF-01 
                 7.603 
                 1314.9 
                 (M − H)− 
               
               
                 2156 
                 SSC-A-FA-01 
                 5.383 
                 1300.7 
                 (M − H)− 
               
               
                 2157 
                 SSC-A-AF-01 
                 7.243 
                 1286.9 
                 (M − H)− 
               
               
                 2158 
                 SSC-A-FA-01 
                 5.564 
                 1316.6 
                 (M + H)+ 
               
               
                 2159 
                 SSC-A-AF-01 
                 7.513 
                 1318.6 
                 (M + H)+ 
               
               
                 2160 
                 SSC-A-FA-01 
                 5.204 
                 1290.6 
                 (M + H)+ 
               
               
                 2161 
                 SSC-A-FA-02 
                 6.656 
                 1469.9 
                 (M − H)− 
               
               
                 2162 
                 SSC-A-FA-02 
                 6.215 
                 1455.6 
                 (M − H)− 
               
               
                 2163 
                 SSC-A-AF-02 
                 8.011 
                 1477.9 
                 (M − H)− 
               
               
                 2164 
                 SSC-A-FA-02 
                 6.060 
                 1429.8 
                 (M − H)− 
               
               
                 2165 
                 SSC-A-AF-02 
                 8.325 
                 1519.9 
                 (M − H)− 
               
               
                 2166 
                 SSC-A-FA-02 
                 6.292 
                 1479.6 
                 (M + H)+ 
               
               
                 2167 
                 SSC-A-FA-02 
                 6.045 
                 1471.8 
                 (M − H)− 
               
               
                 2168 
                 SSC-AF-00 
                 2.245 
                 1471.9 
                 (M − H)− 
               
               
                 2169 
                 SSC-FA-03 
                 2.100 
                 1529.6 
                 (M − H)− 
               
               
                 2170 
                 SSC-AF-00 
                 2.192 
                 1537.9 
                 (M − H)− 
               
               
                 2171 
                 SSC-AF-00 
                 2.287 
                 1533.7 
                 (M − H)− 
               
               
                 2172 
                 SQDFA05long 
                 1.480 
                 1307.1 
                 (M + H)+ 
               
               
                 2173 
                 SQDFA05long 
                 1.160 
                 1303.1 
                 (M + H)+ 
               
               
                 2174 
                 SQDFA05long 
                 1.100 
                 1420.3 
                 (M + H)+ 
               
               
                 2175 
                 SQDFA05long 
                 1.640 
                 1434.3 
                 (M + H)+ 
               
               
                 2176 
                 SQDFA05long 
                 1.880 
                 1506.4 
                 (M + H)+ 
               
               
                 2177 
                 SQDFA05long 
                 1.550 
                 1468.3 
                 (M + H)+ 
               
               
                 2178 
                 SQDFA05long 
                 1.430 
                 1430.3 
                 (M + H)+ 
               
               
                 2179 
                 SQDFA05long 
                 1.170 
                 1416.3 
                 (M + H)+ 
               
               
                 2180 
                 SQDFA05 
                 0.820 
                 1528.3 
                 (M + H)+ 
               
               
                 2181 
                 SQDFA05 
                 0.770 
                 1485.2 
                 (M + H)+ 
               
               
                 2182 
                 SQDFA05long 
                 2.420 
                 1441.2 
                 (M + H)+ 
               
               
                 2183 
                 SQDFA05long 
                 2.550 
                 1475.2 
                 (M + H)+ 
               
               
                 2184 
                 SQDAA50 
                 0.800 
                 1511.7 
                 (M − H)− 
               
               
                 2185 
                 SQDFA05long 
                 2.730 
                 1489.2 
                 (M + H)+ 
               
               
                 2186 
                 SQDFA05long 
                 2.770 
                 1473.3 
                 (M + H)+ 
               
               
                   
               
            
           
         
       
     
     Example 2: Pharmacological Test Example 
     Protein-Protein Interaction Inhibition Between Kras and SOS1 (KrasGl2D-SOS PPI) Using AlphaScreen 
     Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin-conjugated acceptor beads using biotin-tagged human Kras expressed in  E. coli  and loaded with GDP after purification and His-tagged human SOS1 enzyme. This measurement utilizes the phenomenon in which donor beads are irradiated with light at 680 nm, such that energy is transferred to acceptor beads through singlet oxygen and light at 520-620 nm is detected from the acceptor beads. The 50% inhibitory concentration (IC50 value) was calculated from the inhibition rate relative to the test substance-free control group. 
     IC50 values of the test compounds are shown in the following table. The cyclic peptide compounds of the present invention were shown to inhibit the protein-protein interaction between Kras and SOS1. Inhibition of binding between K-ras and SOS1 is known to inhibit signaling downstream of Kras. Accordingly, the compounds of the present invention are also suggested to have cell growth inhibitory activity. 
     
       
         
           
               
               
               
             
               
                   
                 TABLE 23 
               
               
                   
                   
               
               
                   
                 Compound 
                 KRAS G12D-SOS PPI 
               
               
                   
                 No. 
                 IC50(μM) 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 1 
                 0.0059 
               
               
                   
                 2 
                 0.015 
               
               
                   
                 3 
                 0.31 
               
               
                   
                 4 
                 0.013 
               
               
                   
                 5 
                 0.00099 
               
               
                   
                 6 
                 0.013 
               
               
                   
                 7 
                 0.018 
               
               
                   
                 8 
                 0.075 
               
               
                   
                 9 
                 0.0015 
               
               
                   
                 10 
                 0.018 
               
               
                   
                 11 
                 0.0015 
               
               
                   
                 12 
                 0.24 
               
               
                   
                 13 
                 0.038 
               
               
                   
                 14 
                 0.11 
               
               
                   
                 15 
                 0.0033 
               
               
                   
                 16 
                 0.00070 
               
               
                   
                 17 
                 0.030 
               
               
                   
                 18 
                 0.23 
               
               
                   
                 19 
                 0.050 
               
               
                   
                 20 
                 0.00076 
               
               
                   
                 21 
                 0.25 
               
               
                   
                 22 
                 0.11 
               
               
                   
                 23 
                 0.0027 
               
               
                   
                 24 
                 0.025 
               
               
                   
                 25 
                 0.15 
               
               
                   
                 26 
                 0.0043 
               
               
                   
                 27 
                 0.0033 
               
               
                   
                 28 
                 0.16 
               
               
                   
                 29 
                 0.32 
               
               
                   
                 30 
                 0.0046 
               
               
                   
                 31 
                 0.38 
               
               
                   
                 32 
                 0.020 
               
               
                   
                 33 
                 0.0069 
               
               
                   
                 34 
                 0.074 
               
               
                   
                 35 
                 0.0021 
               
               
                   
                 36 
                 0.0047 
               
               
                   
                 37 
                 0.017 
               
               
                   
                 38 
                 0.16 
               
               
                   
                 39 
                 0.011 
               
               
                   
                 40 
                 0.00096 
               
               
                   
                 41 
                 0.011 
               
               
                   
                 42 
                 0.19 
               
               
                   
                 43 
                 0.031 
               
               
                   
                 44 
                 0.0011 
               
               
                   
                 45 
                 0.084 
               
               
                   
                 46 
                 0.12 
               
               
                   
                 47 
                 0.0015 
               
               
                   
                 48 
                 0.00097 
               
               
                   
                 49 
                 0.012 
               
               
                   
                 50 
                 0.028 
               
               
                   
                 51 
                 0.090 
               
               
                   
                 52 
                 0.00066 
               
               
                   
                 53 
                 0.12 
               
               
                   
                 54 
                 0.0019 
               
               
                   
                 55 
                 0.00077 
               
               
                   
                 56 
                 0.0023 
               
               
                   
                 57 
                 0.016 
               
               
                   
                 58 
                 0.028 
               
               
                   
                 59 
                 0.036 
               
               
                   
                 60 
                 0.0079 
               
               
                   
                 61 
                 0.016 
               
               
                   
                 62 
                 0.0038 
               
               
                   
                 63 
                 0.0037 
               
               
                   
                 64 
                 0.13 
               
               
                   
                 65 
                 0.24 
               
               
                   
                 66 
                 0.0036 
               
               
                   
                 67 
                 0.0083 
               
               
                   
                 68 
                 0.00058 
               
               
                   
                 69 
                 0.0088 
               
               
                   
                 70 
                 0.16 
               
               
                   
                 71 
                 0.15 
               
               
                   
                 72 
                 0.00047 
               
               
                   
                 73 
                 0.00033 
               
               
                   
                 74 
                 0.0072 
               
               
                   
                 75 
                 0.094 
               
               
                   
                 76 
                 0.19 
               
               
                   
                 77 
                 0.10 
               
               
                   
                 78 
                 0.0016 
               
               
                   
                 79 
                 0.0093 
               
               
                   
                 80 
                 0.0028 
               
               
                   
                 81 
                 0.014 
               
               
                   
                 82 
                 0.14 
               
               
                   
                 83 
                 0.11 
               
               
                   
                 84 
                 0.073 
               
               
                   
                 85 
                 0.015 
               
               
                   
                 86 
                 0.0090 
               
               
                   
                 87 
                 0.045 
               
               
                   
                 88 
                 0.018 
               
               
                   
                 89 
                 0.0019 
               
               
                   
                 90 
                 0.0050 
               
               
                   
                 91 
                 0.0015 
               
               
                   
                 92 
                 0.0055 
               
               
                   
                 93 
                 0.0069 
               
               
                   
                 94 
                 0.0033 
               
               
                   
                 95 
                 0.011 
               
               
                   
                 96 
                 0.22 
               
               
                   
                 97 
                 0.040 
               
               
                   
                 98 
                 0.068 
               
               
                   
                 99 
                 0.0029 
               
               
                   
                 100 
                 0.0074 
               
               
                   
                 101 
                 0.16 
               
               
                   
                 102 
                 0.011 
               
               
                   
                 103 
                 0.022 
               
               
                   
                 104 
                 0.028 
               
               
                   
                 105 
                 0.0053 
               
               
                   
                 106 
                 0.0089 
               
               
                   
                 107 
                 0.0040 
               
               
                   
                 108 
                 0.0050 
               
               
                   
                 109 
                 0.040 
               
               
                   
                 110 
                 0.0038 
               
               
                   
                 111 
                 0.10 
               
               
                   
                 112 
                 0.073 
               
               
                   
                 113 
                 0.28 
               
               
                   
                 114 
                 0.020 
               
               
                   
                 115 
                 0.0060 
               
               
                   
                 116 
                 0.14 
               
               
                   
                 117 
                 0.021 
               
               
                   
                 118 
                 0.0019 
               
               
                   
                 119 
                 0.039 
               
               
                   
                 120 
                 0.00055 
               
               
                   
                 121 
                 0.0054 
               
               
                   
                 122 
                 0.0086 
               
               
                   
                 123 
                 0.17 
               
               
                   
                 124 
                 0.14 
               
               
                   
                 125 
                 0.0028 
               
               
                   
                 126 
                 0.00050 
               
               
                   
                 127 
                 0.00043 
               
               
                   
                 128 
                 0.0016 
               
               
                   
                 129 
                 0.011 
               
               
                   
                 130 
                 0.010 
               
               
                   
                 131 
                 0.0033 
               
               
                   
                 132 
                 0.00096 
               
               
                   
                 133 
                 0.023 
               
               
                   
                 134 
                 0.00061 
               
               
                   
                 135 
                 0.038 
               
               
                   
                 136 
                 0.0077 
               
               
                   
                 137 
                 0.00076 
               
               
                   
                 138 
                 0.044 
               
               
                   
                 139 
                 0.0084 
               
               
                   
                 140 
                 0.00081 
               
               
                   
                 141 
                 0.032 
               
               
                   
                 142 
                 0.038 
               
               
                   
                 143 
                 0.068 
               
               
                   
                 144 
                 0.0011 
               
               
                   
                 145 
                 0.025 
               
               
                   
                 146 
                 0.0040 
               
               
                   
                 147 
                 0.0067 
               
               
                   
                 148 
                 0.0018 
               
               
                   
                 149 
                 0.051 
               
               
                   
                 150 
                 0.0013 
               
               
                   
                 151 
                 0.0050 
               
               
                   
                 152 
                 0.11 
               
               
                   
                 153 
                 0.060 
               
               
                   
                 154 
                 0.0048 
               
               
                   
                 155 
                 0.0016 
               
               
                   
                 156 
                 0.00098 
               
               
                   
                 157 
                 0.0075 
               
               
                   
                 158 
                 0.010 
               
               
                   
                 159 
                 0.0024 
               
               
                   
                 160 
                 0.0010 
               
               
                   
                 161 
                 0.00082 
               
               
                   
                 162 
                 0.23 
               
               
                   
                 163 
                 0.0061 
               
               
                   
                 164 
                 0.0022 
               
               
                   
                 165 
                 0.041 
               
               
                   
                 166 
                 0.021 
               
               
                   
                 167 
                 0.058 
               
               
                   
                 168 
                 0.029 
               
               
                   
                 169 
                 0.016 
               
               
                   
                 170 
                 0.35 
               
               
                   
                 171 
                 0.014 
               
               
                   
                 172 
                 0.0040 
               
               
                   
                 173 
                 0.00056 
               
               
                   
                 174 
                 0.057 
               
               
                   
                 175 
                 0.012 
               
               
                   
                 176 
                 0.0014 
               
               
                   
                 177 
                 0.045 
               
               
                   
                 178 
                 0.022 
               
               
                   
                 179 
                 0.042 
               
               
                   
                 180 
                 0.011 
               
               
                   
                 181 
                 0.13 
               
               
                   
                 182 
                 0.00098 
               
               
                   
                 183 
                 0.026 
               
               
                   
                 184 
                 0.32 
               
               
                   
                 185 
                 0.17 
               
               
                   
                 186 
                 0.048 
               
               
                   
                 187 
                 0.0032 
               
               
                   
                 188 
                 0.0061 
               
               
                   
                 189 
                 0.11 
               
               
                   
                 190 
                 0.15 
               
               
                   
                 191 
                 0.0034 
               
               
                   
                 192 
                 0.022 
               
               
                   
                 193 
                 0.42 
               
               
                   
                 194 
                 0.027 
               
               
                   
                 195 
                 0.0095 
               
               
                   
                 196 
                 0.013 
               
               
                   
                 197 
                 0.0068 
               
               
                   
                 198 
                 0.0085 
               
               
                   
                 199 
                 0.036 
               
               
                   
                 200 
                 0.013 
               
               
                   
                 201 
                 0.00058 
               
               
                   
                 202 
                 0.039 
               
               
                   
                 203 
                 0.031 
               
               
                   
                 204 
                 0.18 
               
               
                   
                 205 
                 0.00049 
               
               
                   
                 206 
                 0.11 
               
               
                   
                 207 
                 0.0030 
               
               
                   
                 208 
                 0.12 
               
               
                   
                 209 
                 0.0016 
               
               
                   
                 210 
                 0.080 
               
               
                   
                 211 
                 0.043 
               
               
                   
                 212 
                 0.042 
               
               
                   
                 213 
                 0.048 
               
               
                   
                 214 
                 0.28 
               
               
                   
                 215 
                 0.029 
               
               
                   
                 216 
                 0.0080 
               
               
                   
                 217 
                 0.066 
               
               
                   
                 218 
                 0.0019 
               
               
                   
                 219 
                 0.073 
               
               
                   
                 220 
                 0.0031 
               
               
                   
                 221 
                 0.0028 
               
               
                   
                 222 
                 0.020 
               
               
                   
                 223 
                 0.018 
               
               
                   
                 224 
                 0.23 
               
               
                   
                 225 
                 0.015 
               
               
                   
                 226 
                 0.0035 
               
               
                   
                 227 
                 0.082 
               
               
                   
                 228 
                 0.024 
               
               
                   
                 229 
                 0.0067 
               
               
                   
                 230 
                 0.039 
               
               
                   
                 231 
                 0.12 
               
               
                   
                 232 
                 0.020 
               
               
                   
                 233 
                 0.066 
               
               
                   
                 234 
                 0.0021 
               
               
                   
                 235 
                 0.011 
               
               
                   
                 236 
                 0.0085 
               
               
                   
                 237 
                 0.042 
               
               
                   
                 238 
                 0.012 
               
               
                   
                 239 
                 0.00077 
               
               
                   
                 240 
                 0.14 
               
               
                   
                 241 
                 0.018 
               
               
                   
                 242 
                 0.027 
               
               
                   
                 243 
                 0.00043 
               
               
                   
                 244 
                 0.14 
               
               
                   
                 245 
                 0.00037 
               
               
                   
                 246 
                 0.00030 
               
               
                   
                 247 
                 0.0070 
               
               
                   
                 248 
                 0.031 
               
               
                   
                 249 
                 0.0016 
               
               
                   
                 250 
                 0.0098 
               
               
                   
                 251 
                 0.0038 
               
               
                   
                 252 
                 0.055 
               
               
                   
                 253 
                 0.00099 
               
               
                   
                 254 
                 0.015 
               
               
                   
                 255 
                 0.0078 
               
               
                   
                 256 
                 0.00098 
               
               
                   
                 257 
                 0.097 
               
               
                   
                 258 
                 0.036 
               
               
                   
                 259 
                 0.021 
               
               
                   
                 260 
                 0.050 
               
               
                   
                 261 
                 0.052 
               
               
                   
                 262 
                 0.043 
               
               
                   
                 263 
                 0.0029 
               
               
                   
                 264 
                 0.0045 
               
               
                   
                 265 
                 0.28 
               
               
                   
                 266 
                 0.0046 
               
               
                   
                 267 
                 0.13 
               
               
                   
                 268 
                 0.018 
               
               
                   
                 269 
                 0.0034 
               
               
                   
                 270 
                 0.00067 
               
               
                   
                 271 
                 0.065 
               
               
                   
                 272 
                 0.00052 
               
               
                   
                 273 
                 0.036 
               
               
                   
                 274 
                 0.00082 
               
               
                   
                 275 
                 0.046 
               
               
                   
                 276 
                 0.00076 
               
               
                   
                 277 
                 0.0051 
               
               
                   
                 278 
                 0.025 
               
               
                   
                 279 
                 0.00099 
               
               
                   
                 280 
                 0.024 
               
               
                   
                 281 
                 0.0078 
               
               
                   
                 282 
                 0.094 
               
               
                   
                 283 
                 0.0068 
               
               
                   
                 284 
                 0.071 
               
               
                   
                 285 
                 0.052 
               
               
                   
                 286 
                 0.096 
               
               
                   
                 287 
                 0.0051 
               
               
                   
                 288 
                 0.0017 
               
               
                   
                 289 
                 0.00030 
               
               
                   
                 290 
                 0.16 
               
               
                   
                 291 
                 0.055 
               
               
                   
                 292 
                 0.00045 
               
               
                   
                 293 
                 0.12 
               
               
                   
                 294 
                 0.0014 
               
               
                   
                 295 
                 0.068 
               
               
                   
                 296 
                 0.055 
               
               
                   
                 297 
                 0.049 
               
               
                   
                 298 
                 0.021 
               
               
                   
                 299 
                 0.13 
               
               
                   
                 300 
                 0.0095 
               
               
                   
                 301 
                 0.00074 
               
               
                   
                 302 
                 0.00068 
               
               
                   
                 303 
                 0.00068 
               
               
                   
                 304 
                 0.087 
               
               
                   
                 305 
                 0.17 
               
               
                   
                 306 
                 0.044 
               
               
                   
                 307 
                 0.0044 
               
               
                   
                 308 
                 0.00093 
               
               
                   
                 309 
                 0.00075 
               
               
                   
                 310 
                 0.096 
               
               
                   
                 311 
                 0.0059 
               
               
                   
                 312 
                 0.0010 
               
               
                   
                 313 
                 0.0042 
               
               
                   
                 314 
                 0.0026 
               
               
                   
                 315 
                 0.12 
               
               
                   
                 316 
                 0.0033 
               
               
                   
                 317 
                 0.030 
               
               
                   
                 318 
                 0.019 
               
               
                   
                 319 
                 0.0082 
               
               
                   
                 320 
                 0.0099 
               
               
                   
                 321 
                 0.011 
               
               
                   
                 322 
                 0.031 
               
               
                   
                 323 
                 0.14 
               
               
                   
                 324 
                 0.38 
               
               
                   
                 325 
                 0.014 
               
               
                   
                 326 
                 0.00070 
               
               
                   
                 327 
                 0.00047 
               
               
                   
                 328 
                 0.094 
               
               
                   
                 329 
                 0.040 
               
               
                   
                 330 
                 0.080 
               
               
                   
                 331 
                 0.030 
               
               
                   
                 332 
                 0.21 
               
               
                   
                 333 
                 0.11 
               
               
                   
                 334 
                 0.00050 
               
               
                   
                 335 
                 0.067 
               
               
                   
                 336 
                 0.093 
               
               
                   
                 337 
                 0.016 
               
               
                   
                 338 
                 0.22 
               
               
                   
                 339 
                 0.00038 
               
               
                   
                 340 
                 0.0047 
               
               
                   
                 341 
                 0.0029 
               
               
                   
                 342 
                 0.00095 
               
               
                   
                 343 
                 0.00087 
               
               
                   
                 344 
                 0.00083 
               
               
                   
                 345 
                 0.058 
               
               
                   
                 346 
                 0.011 
               
               
                   
                 347 
                 0.027 
               
               
                   
                 348 
                 0.0060 
               
               
                   
                 349 
                 0.19 
               
               
                   
                 350 
                 0.064 
               
               
                   
                 351 
                 0.28 
               
               
                   
                 352 
                 0.0055 
               
               
                   
                 353 
                 0.00069 
               
               
                   
                 354 
                 0.0016 
               
               
                   
                 355 
                 0.053 
               
               
                   
                 356 
                 0.00092 
               
               
                   
                 357 
                 0.022 
               
               
                   
                 358 
                 0.033 
               
               
                   
                 359 
                 0.0032 
               
               
                   
                 360 
                 0.0028 
               
               
                   
                 361 
                 0.34 
               
               
                   
                 362 
                 0.00066 
               
               
                   
                 363 
                 0.00065 
               
               
                   
                 364 
                 0.0097 
               
               
                   
                 365 
                 0.038 
               
               
                   
                 366 
                 0.0040 
               
               
                   
                 367 
                 0.00060 
               
               
                   
                 368 
                 0.0027 
               
               
                   
                 369 
                 0.35 
               
               
                   
                 370 
                 0.00035 
               
               
                   
                 371 
                 0.0013 
               
               
                   
                 372 
                 0.13 
               
               
                   
                 373 
                 0.33 
               
               
                   
                 374 
                 0.0065 
               
               
                   
                 375 
                 0.012 
               
               
                   
                 376 
                 0.044 
               
               
                   
                 377 
                 0.024 
               
               
                   
                 378 
                 0.00068 
               
               
                   
                 379 
                 0.013 
               
               
                   
                 380 
                 0.0056 
               
               
                   
                 381 
                 0.0016 
               
               
                   
                 382 
                 0.035 
               
               
                   
                 383 
                 0.26 
               
               
                   
                 384 
                 0.0010 
               
               
                   
                 385 
                 0.0047 
               
               
                   
                 386 
                 0.010 
               
               
                   
                 387 
                 0.0042 
               
               
                   
                 388 
                 0.00050 
               
               
                   
                 389 
                 0.045 
               
               
                   
                 390 
                 0.00077 
               
               
                   
                 391 
                 0.00040 
               
               
                   
                 392 
                 0.012 
               
               
                   
                 393 
                 0.0053 
               
               
                   
                 394 
                 0.013 
               
               
                   
                 395 
                 0.047 
               
               
                   
                 396 
                 0.22 
               
               
                   
                 397 
                 0.0023 
               
               
                   
                 398 
                 0.12 
               
               
                   
                 399 
                 0.0089 
               
               
                   
                 400 
                 0.00085 
               
               
                   
                 401 
                 0.0036 
               
               
                   
                 402 
                 0.026 
               
               
                   
                 403 
                 0.0011 
               
               
                   
                 404 
                 0.0048 
               
               
                   
                 405 
                 0.27 
               
               
                   
                 406 
                 0.25 
               
               
                   
                 407 
                 0.039 
               
               
                   
                 408 
                 0.011 
               
               
                   
                 409 
                 0.0024 
               
               
                   
                 410 
                 0.00048 
               
               
                   
                 411 
                 0.00062 
               
               
                   
                 412 
                 0.12 
               
               
                   
                 413 
                 0.050 
               
               
                   
                 414 
                 0.11 
               
               
                   
                 415 
                 0.0015 
               
               
                   
                 416 
                 0.054 
               
               
                   
                 417 
                 0.015 
               
               
                   
                 418 
                 0.017 
               
               
                   
                 419 
                 0.0024 
               
               
                   
                 420 
                 0.0034 
               
               
                   
                 421 
                 0.010 
               
               
                   
                 422 
                 0.00087 
               
               
                   
                 423 
                 0.064 
               
               
                   
                 424 
                 0.011 
               
               
                   
                 425 
                 0.00057 
               
               
                   
                 426 
                 0.0087 
               
               
                   
                 427 
                 0.00071 
               
               
                   
                 428 
                 0.0091 
               
               
                   
                 429 
                 0.099 
               
               
                   
                 430 
                 0.039 
               
               
                   
                 431 
                 0.25 
               
               
                   
                 432 
                 0.0045 
               
               
                   
                 433 
                 0.0022 
               
               
                   
                 434 
                 0.00052 
               
               
                   
                 435 
                 0.25 
               
               
                   
                 436 
                 0.16 
               
               
                   
                 437 
                 0.00047 
               
               
                   
                 438 
                 0.0060 
               
               
                   
                 439 
                 0.052 
               
               
                   
                 440 
                 0.0029 
               
               
                   
                 441 
                 0.00073 
               
               
                   
                 442 
                 0.070 
               
               
                   
                 443 
                 0.030 
               
               
                   
                 444 
                 0.018 
               
               
                   
                 445 
                 0.00067 
               
               
                   
                 446 
                 0.0018 
               
               
                   
                 447 
                 0.014 
               
               
                   
                 448 
                 0.091 
               
               
                   
                 449 
                 0.030 
               
               
                   
                 450 
                 0.0066 
               
               
                   
                 451 
                 0.010 
               
               
                   
                 452 
                 0.080 
               
               
                   
                 453 
                 0.017 
               
               
                   
                 454 
                 0.0027 
               
               
                   
                 455 
                 0.059 
               
               
                   
                 456 
                 0.034 
               
               
                   
                 457 
                 0.069 
               
               
                   
                 458 
                 0.0059 
               
               
                   
                 459 
                 0.0095 
               
               
                   
                 460 
                 0.0010 
               
               
                   
                 461 
                 0.0012 
               
               
                   
                 462 
                 0.012 
               
               
                   
                 463 
                 0.0044 
               
               
                   
                 464 
                 0.13 
               
               
                   
                 465 
                 0.055 
               
               
                   
                 466 
                 0.0031 
               
               
                   
                 467 
                 0.20 
               
               
                   
                 468 
                 0.0025 
               
               
                   
                 469 
                 0.0036 
               
               
                   
                 470 
                 0.0022 
               
               
                   
                 471 
                 0.058 
               
               
                   
                 472 
                 0.14 
               
               
                   
                 473 
                 0.41 
               
               
                   
                 474 
                 0.28 
               
               
                   
                 475 
                 0.051 
               
               
                   
                 476 
                 0.0041 
               
               
                   
                 477 
                 0.0043 
               
               
                   
                 478 
                 0.0030 
               
               
                   
                 479 
                 0.30 
               
               
                   
                 480 
                 0.0014 
               
               
                   
                 481 
                 0.0020 
               
               
                   
                 482 
                 0.17 
               
               
                   
                 483 
                 0.017 
               
               
                   
                 484 
                 0.11 
               
               
                   
                 485 
                 0.16 
               
               
                   
                 486 
                 0.0048 
               
               
                   
                 487 
                 0.0059 
               
               
                   
                 488 
                 0.029 
               
               
                   
                 489 
                 0.0081 
               
               
                   
                 490 
                 0.24 
               
               
                   
                 491 
                 0.00035 
               
               
                   
                 492 
                 0.012 
               
               
                   
                 493 
                 0.30 
               
               
                   
                 494 
                 0.0086 
               
               
                   
                 495 
                 0.0032 
               
               
                   
                 496 
                 0.010 
               
               
                   
                 497 
                 0.0043 
               
               
                   
                 498 
                 0.049 
               
               
                   
                 499 
                 0.085 
               
               
                   
                 500 
                 0.0048 
               
               
                   
                 501 
                 0.16 
               
               
                   
                 502 
                 0.047 
               
               
                   
                 503 
                 0.0071 
               
               
                   
                 504 
                 0.053 
               
               
                   
                 505 
                 0.086 
               
               
                   
                 506 
                 0.00068 
               
               
                   
                 507 
                 0.00048 
               
               
                   
                 508 
                 0.012 
               
               
                   
                 509 
                 0.0013 
               
               
                   
                 510 
                 0.0040 
               
               
                   
                 511 
                 0.090 
               
               
                   
                 512 
                 0.15 
               
               
                   
                 513 
                 0.046 
               
               
                   
                 514 
                 0.014 
               
               
                   
                 515 
                 0.00055 
               
               
                   
                 516 
                 0.062 
               
               
                   
                 517 
                 0.028 
               
               
                   
                 518 
                 0.00067 
               
               
                   
                 519 
                 0.0020 
               
               
                   
                 520 
                 0.017 
               
               
                   
                 521 
                 0.071 
               
               
                   
                 522 
                 0.0053 
               
               
                   
                 523 
                 0.0058 
               
               
                   
                 524 
                 0.082 
               
               
                   
                 525 
                 0.0023 
               
               
                   
                 526 
                 0.0066 
               
               
                   
                 527 
                 0.038 
               
               
                   
                 528 
                 0.020 
               
               
                   
                 529 
                 0.0082 
               
               
                   
                 530 
                 0.14 
               
               
                   
                 531 
                 0.0016 
               
               
                   
                 532 
                 0.00048 
               
               
                   
                 533 
                 0.0085 
               
               
                   
                 534 
                 0.013 
               
               
                   
                 535 
                 0.00065 
               
               
                   
                 536 
                 0.23 
               
               
                   
                 537 
                 0.082 
               
               
                   
                 538 
                 0.11 
               
               
                   
                 539 
                 0.19 
               
               
                   
                 540 
                 0.15 
               
               
                   
                 541 
                 0.0043 
               
               
                   
                 542 
                 0.061 
               
               
                   
                 543 
                 0.00056 
               
               
                   
                 544 
                 0.0022 
               
               
                   
                 545 
                 0.0011 
               
               
                   
                 546 
                 0.13 
               
               
                   
                 547 
                 0.0010 
               
               
                   
                 548 
                 0.0016 
               
               
                   
                 549 
                 0.0040 
               
               
                   
                 550 
                 0.11 
               
               
                   
                 551 
                 0.00052 
               
               
                   
                 552 
                 0.00063 
               
               
                   
                 553 
                 0.027 
               
               
                   
                 554 
                 0.0053 
               
               
                   
                 555 
                 0.0026 
               
               
                   
                 556 
                 0.030 
               
               
                   
                 557 
                 0.0044 
               
               
                   
                 558 
                 0.0018 
               
               
                   
                 559 
                 0.0017 
               
               
                   
                 560 
                 0.11 
               
               
                   
                 561 
                 0.0034 
               
               
                   
                 562 
                 0.00056 
               
               
                   
                 563 
                 0.0011 
               
               
                   
                 564 
                 0.0096 
               
               
                   
                 565 
                 0.055 
               
               
                   
                 566 
                 0.16 
               
               
                   
                 567 
                 0.0015 
               
               
                   
                 568 
                 0.0080 
               
               
                   
                 569 
                 0.073 
               
               
                   
                 570 
                 0.027 
               
               
                   
                 571 
                 0.00083 
               
               
                   
                 572 
                 0.039 
               
               
                   
                 573 
                 0.010 
               
               
                   
                 574 
                 0.0086 
               
               
                   
                 575 
                 0.00056 
               
               
                   
                 576 
                 0.23 
               
               
                   
                 577 
                 0.021 
               
               
                   
                 578 
                 0.12 
               
               
                   
                 579 
                 0.017 
               
               
                   
                 580 
                 0.066 
               
               
                   
                 581 
                 0.032 
               
               
                   
                 582 
                 0.024 
               
               
                   
                 583 
                 0.37 
               
               
                   
                 584 
                 0.031 
               
               
                   
                 585 
                 0.094 
               
               
                   
                 586 
                 0.16 
               
               
                   
                 587 
                 0.0012 
               
               
                   
                 588 
                 0.36 
               
               
                   
                 589 
                 0.00049 
               
               
                   
                 590 
                 0.0014 
               
               
                   
                 591 
                 0.0021 
               
               
                   
                 592 
                 0.026 
               
               
                   
                 593 
                 0.034 
               
               
                   
                 594 
                 0.00054 
               
               
                   
                 595 
                 0.29 
               
               
                   
                 596 
                 0.034 
               
               
                   
                 597 
                 0.011 
               
               
                   
                 598 
                 0.30 
               
               
                   
                 599 
                 0.012 
               
               
                   
                 600 
                 0.0045 
               
               
                   
                 601 
                 0.087 
               
               
                   
                 602 
                 0.28 
               
               
                   
                 603 
                 0.00089 
               
               
                   
                 604 
                 0.016 
               
               
                   
                 605 
                 0.0090 
               
               
                   
                 606 
                 0.0083 
               
               
                   
                 607 
                 0.22 
               
               
                   
                 608 
                 0.0059 
               
               
                   
                 609 
                 0.11 
               
               
                   
                 610 
                 0.15 
               
               
                   
                 611 
                 0.0033 
               
               
                   
                 612 
                 0.12 
               
               
                   
                 613 
                 0.50 
               
               
                   
                 614 
                 0.024 
               
               
                   
                 615 
                 0.22 
               
               
                   
                 616 
                 0.0039 
               
               
                   
                 617 
                 0.11 
               
               
                   
                 618 
                 0.0024 
               
               
                   
                 619 
                 0.019 
               
               
                   
                 620 
                 0.011 
               
               
                   
                 621 
                 0.059 
               
               
                   
                 622 
                 0.0017 
               
               
                   
                 623 
                 0.0018 
               
               
                   
                 624 
                 0.16 
               
               
                   
                 625 
                 0.070 
               
               
                   
                 626 
                 0.0024 
               
               
                   
                 627 
                 0.013 
               
               
                   
                 628 
                 0.020 
               
               
                   
                 629 
                 0.010 
               
               
                   
                 630 
                 0.0017 
               
               
                   
                 631 
                 0.0010 
               
               
                   
                 632 
                 0.073 
               
               
                   
                 633 
                 0.12 
               
               
                   
                 634 
                 0.26 
               
               
                   
                 635 
                 0.19 
               
               
                   
                 636 
                 0.0011 
               
               
                   
                 637 
                 0.026 
               
               
                   
                 638 
                 0.045 
               
               
                   
                 639 
                 0.014 
               
               
                   
                 640 
                 0.00086 
               
               
                   
                 641 
                 0.018 
               
               
                   
                 642 
                 0.054 
               
               
                   
                 643 
                 0.027 
               
               
                   
                 644 
                 0.017 
               
               
                   
                 645 
                 0.058 
               
               
                   
                 646 
                 0.12 
               
               
                   
                 647 
                 0.00058 
               
               
                   
                 648 
                 0.0032 
               
               
                   
                 649 
                 0.36 
               
               
                   
                 650 
                 0.00060 
               
               
                   
                 651 
                 0.086 
               
               
                   
                 652 
                 0.0043 
               
               
                   
                 653 
                 0.044 
               
               
                   
                 654 
                 0.11 
               
               
                   
                 655 
                 0.0049 
               
               
                   
                 656 
                 0.017 
               
               
                   
                 657 
                 0.31 
               
               
                   
                 658 
                 0.15 
               
               
                   
                 659 
                 0.13 
               
               
                   
                 660 
                 0.21 
               
               
                   
                 661 
                 0.013 
               
               
                   
                 662 
                 0.0032 
               
               
                   
                 663 
                 0.016 
               
               
                   
                 664 
                 0.025 
               
               
                   
                 665 
                 0.037 
               
               
                   
                 666 
                 0.025 
               
               
                   
                 667 
                 0.0051 
               
               
                   
                 668 
                 0.0019 
               
               
                   
                 669 
                 0.22 
               
               
                   
                 670 
                 0.0051 
               
               
                   
                 671 
                 0.052 
               
               
                   
                 672 
                 0.0025 
               
               
                   
                 673 
                 0.011 
               
               
                   
                 674 
                 0.0056 
               
               
                   
                 675 
                 0.059 
               
               
                   
                 676 
                 0.031 
               
               
                   
                 677 
                 0.0041 
               
               
                   
                 678 
                 0.0017 
               
               
                   
                 679 
                 0.037 
               
               
                   
                 680 
                 0.0099 
               
               
                   
                 681 
                 0.0059 
               
               
                   
                 682 
                 0.020 
               
               
                   
                 683 
                 0.00061 
               
               
                   
                 684 
                 0.0019 
               
               
                   
                 685 
                 0.13 
               
               
                   
                 686 
                 0.17 
               
               
                   
                 687 
                 0.016 
               
               
                   
                 688 
                 0.0023 
               
               
                   
                 689 
                 0.0021 
               
               
                   
                 690 
                 0.0018 
               
               
                   
                 691 
                 0.0071 
               
               
                   
                 692 
                 0.0069 
               
               
                   
                 693 
                 0.0016 
               
               
                   
                 694 
                 0.014 
               
               
                   
                 695 
                 0.0023 
               
               
                   
                 696 
                 0.040 
               
               
                   
                 697 
                 0.012 
               
               
                   
                 698 
                 0.023 
               
               
                   
                 699 
                 0.00083 
               
               
                   
                 700 
                 0.0050 
               
               
                   
                 701 
                 0.00069 
               
               
                   
                 702 
                 0.13 
               
               
                   
                 703 
                 0.0085 
               
               
                   
                 704 
                 0.013 
               
               
                   
                 705 
                 0.36 
               
               
                   
                 706 
                 0.066 
               
               
                   
                 707 
                 0.014 
               
               
                   
                 708 
                 0.011 
               
               
                   
                 709 
                 0.041 
               
               
                   
                 710 
                 0.0044 
               
               
                   
                 711 
                 0.035 
               
               
                   
                 712 
                 0.0027 
               
               
                   
                 713 
                 0.0040 
               
               
                   
                 714 
                 0.0023 
               
               
                   
                 715 
                 0.0061 
               
               
                   
                 716 
                 0.0011 
               
               
                   
                 717 
                 0.00086 
               
               
                   
                 718 
                 0.039 
               
               
                   
                 719 
                 0.0059 
               
               
                   
                 720 
                 0.039 
               
               
                   
                 721 
                 0.0015 
               
               
                   
                 722 
                 0.42 
               
               
                   
                 723 
                 0.017 
               
               
                   
                 724 
                 0.024 
               
               
                   
                 725 
                 0.0078 
               
               
                   
                 726 
                 0.0013 
               
               
                   
                 727 
                 0.0069 
               
               
                   
                 728 
                 0.016 
               
               
                   
                 729 
                 0.043 
               
               
                   
                 730 
                 0.012 
               
               
                   
                 731 
                 0.0035 
               
               
                   
                 732 
                 0.0014 
               
               
                   
                 733 
                 0.051 
               
               
                   
                 734 
                 0.0022 
               
               
                   
                 735 
                 0.00044 
               
               
                   
                 736 
                 0.037 
               
               
                   
                 737 
                 0.11 
               
               
                   
                 738 
                 0.015 
               
               
                   
                 739 
                 0.036 
               
               
                   
                 740 
                 0.011 
               
               
                   
                 741 
                 0.086 
               
               
                   
                 742 
                 0.017 
               
               
                   
                 743 
                 0.040 
               
               
                   
                 744 
                 0.0075 
               
               
                   
                 745 
                 0.029 
               
               
                   
                 746 
                 0.13 
               
               
                   
                 747 
                 0.011 
               
               
                   
                 748 
                 0.13 
               
               
                   
                 749 
                 0.0028 
               
               
                   
                 750 
                 0.028 
               
               
                   
                 751 
                 0.082 
               
               
                   
                 752 
                 0.20 
               
               
                   
                 753 
                 0.035 
               
               
                   
                 754 
                 0.024 
               
               
                   
                 755 
                 0.0056 
               
               
                   
                 756 
                 0.00058 
               
               
                   
                 757 
                 0.0037 
               
               
                   
                 758 
                 0.14 
               
               
                   
                 759 
                 0.16 
               
               
                   
                 760 
                 0.0052 
               
               
                   
                 761 
                 0.00057 
               
               
                   
                 762 
                 0.0055 
               
               
                   
                 764 
                 0.083 
               
               
                   
                 765 
                 0.050 
               
               
                   
                 766 
                 0.13 
               
               
                   
                 767 
                 0.024 
               
               
                   
                 768 
                 0.0011 
               
               
                   
                 769 
                 0.052 
               
               
                   
                 770 
                 0.020 
               
               
                   
                 771 
                 0.025 
               
               
                   
                 772 
                 0.15 
               
               
                   
                 773 
                 0.14 
               
               
                   
                 774 
                 0.00055 
               
               
                   
                 775 
                 0.0046 
               
               
                   
                 776 
                 0.0073 
               
               
                   
                 777 
                 0.33 
               
               
                   
                 778 
                 0.00070 
               
               
                   
                 779 
                 0.16 
               
               
                   
                 780 
                 0.021 
               
               
                   
                 781 
                 0.060 
               
               
                   
                 782 
                 0.021 
               
               
                   
                 783 
                 0.0098 
               
               
                   
                 784 
                 0.0040 
               
               
                   
                 785 
                 0.0035 
               
               
                   
                 786 
                 0.0060 
               
               
                   
                 787 
                 0.0029 
               
               
                   
                 788 
                 0.013 
               
               
                   
                 789 
                 0.00061 
               
               
                   
                 790 
                 0.0025 
               
               
                   
                 791 
                 0.32 
               
               
                   
                 792 
                 0.0035 
               
               
                   
                 793 
                 0.024 
               
               
                   
                 794 
                 0.011 
               
               
                   
                 795 
                 0.072 
               
               
                   
                 796 
                 0.0093 
               
               
                   
                 797 
                 0.019 
               
               
                   
                 798 
                 0.059 
               
               
                   
                 799 
                 0.0014 
               
               
                   
                 800 
                 0.086 
               
               
                   
                 801 
                 0.45 
               
               
                   
                 802 
                 0.39 
               
               
                   
                 803 
                 0.30 
               
               
                   
                 804 
                 0.00099 
               
               
                   
                 805 
                 0.038 
               
               
                   
                 806 
                 0.0011 
               
               
                   
                 807 
                 0.00074 
               
               
                   
                 808 
                 0.099 
               
               
                   
                 809 
                 0.047 
               
               
                   
                 810 
                 0.049 
               
               
                   
                 811 
                 0.059 
               
               
                   
                 812 
                 0.036 
               
               
                   
                 813 
                 0.069 
               
               
                   
                 814 
                 0.00041 
               
               
                   
                 815 
                 0.026 
               
               
                   
                 816 
                 0.0039 
               
               
                   
                 817 
                 0.015 
               
               
                   
                 818 
                 0.0012 
               
               
                   
                 819 
                 0.053 
               
               
                   
                 820 
                 0.00073 
               
               
                   
                 821 
                 0.012 
               
               
                   
                 822 
                 0.15 
               
               
                   
                 823 
                 0.016 
               
               
                   
                 824 
                 0.0056 
               
               
                   
                 825 
                 0.00035 
               
               
                   
                 826 
                 0.11 
               
               
                   
                 827 
                 0.0028 
               
               
                   
                 828 
                 0.040 
               
               
                   
                 829 
                 0.0023 
               
               
                   
                 830 
                 0.28 
               
               
                   
                 831 
                 0.18 
               
               
                   
                 832 
                 0.12 
               
               
                   
                 833 
                 0.0091 
               
               
                   
                 834 
                 0.057 
               
               
                   
                 835 
                 0.00054 
               
               
                   
                 836 
                 0.00066 
               
               
                   
                 837 
                 0.0060 
               
               
                   
                 838 
                 0.010 
               
               
                   
                 839 
                 0.22 
               
               
                   
                 840 
                 0.0012 
               
               
                   
                 841 
                 0.024 
               
               
                   
                 842 
                 0.043 
               
               
                   
                 843 
                 0.049 
               
               
                   
                 844 
                 0.028 
               
               
                   
                 845 
                 0.0082 
               
               
                   
                 847 
                 0.054 
               
               
                   
                 848 
                 0.016 
               
               
                   
                 849 
                 0.0019 
               
               
                   
                 850 
                 0.024 
               
               
                   
                 851 
                 0.027 
               
               
                   
                 852 
                 0.19 
               
               
                   
                 853 
                 0.00062 
               
               
                   
                 854 
                 0.011 
               
               
                   
                 855 
                 0.0084 
               
               
                   
                 856 
                 0.014 
               
               
                   
                 857 
                 0.017 
               
               
                   
                 858 
                 0.33 
               
               
                   
                 859 
                 0.064 
               
               
                   
                 860 
                 0.21 
               
               
                   
                 861 
                 0.0045 
               
               
                   
                 862 
                 0.0027 
               
               
                   
                 863 
                 0.0025 
               
               
                   
                 864 
                 0.073 
               
               
                   
                 865 
                 0.055 
               
               
                   
                 866 
                 0.0012 
               
               
                   
                 867 
                 0.0034 
               
               
                   
                 868 
                 0.0029 
               
               
                   
                 869 
                 0.0098 
               
               
                   
                 870 
                 0.015 
               
               
                   
                 871 
                 0.00078 
               
               
                   
                 872 
                 0.0019 
               
               
                   
                 873 
                 0.051 
               
               
                   
                 874 
                 0.025 
               
               
                   
                 875 
                 0.0031 
               
               
                   
                 876 
                 0.018 
               
               
                   
                 877 
                 0.0025 
               
               
                   
                 878 
                 0.32 
               
               
                   
                 879 
                 0.036 
               
               
                   
                 880 
                 0.0029 
               
               
                   
                 881 
                 0.00056 
               
               
                   
                 882 
                 0.00047 
               
               
                   
                 883 
                 0.049 
               
               
                   
                 884 
                 0.063 
               
               
                   
                 885 
                 0.0019 
               
               
                   
                 886 
                 0.10 
               
               
                   
                 887 
                 0.0062 
               
               
                   
                 888 
                 0.0039 
               
               
                   
                 889 
                 0.070 
               
               
                   
                 890 
                 0.00047 
               
               
                   
                 891 
                 0.0096 
               
               
                   
                 892 
                 0.068 
               
               
                   
                 893 
                 0.021 
               
               
                   
                 894 
                 0.011 
               
               
                   
                 895 
                 0.0084 
               
               
                   
                 896 
                 0.0011 
               
               
                   
                 897 
                 0.15 
               
               
                   
                 898 
                 0.012 
               
               
                   
                 899 
                 0.0019 
               
               
                   
                 900 
                 0.00084 
               
               
                   
                 901 
                 0.035 
               
               
                   
                 902 
                 0.14 
               
               
                   
                 903 
                 0.024 
               
               
                   
                 904 
                 0.0073 
               
               
                   
                 905 
                 0.18 
               
               
                   
                 906 
                 0.0027 
               
               
                   
                 907 
                 0.0014 
               
               
                   
                 908 
                 0.039 
               
               
                   
                 909 
                 0.020 
               
               
                   
                 910 
                 0.0043 
               
               
                   
                 911 
                 0.0045 
               
               
                   
                 912 
                 0.012 
               
               
                   
                 913 
                 0.053 
               
               
                   
                 914 
                 0.0011 
               
               
                   
                 915 
                 0.040 
               
               
                   
                 916 
                 0.042 
               
               
                   
                 917 
                 0.0020 
               
               
                   
                 918 
                 0.00089 
               
               
                   
                 919 
                 0.052 
               
               
                   
                 920 
                 0.015 
               
               
                   
                 921 
                 0.0011 
               
               
                   
                 922 
                 0.23 
               
               
                   
                 923 
                 0.23 
               
               
                   
                 924 
                 0.13 
               
               
                   
                 925 
                 0.36 
               
               
                   
                 926 
                 0.00099 
               
               
                   
                 927 
                 0.023 
               
               
                   
                 928 
                 0.027 
               
               
                   
                 929 
                 0.0041 
               
               
                   
                 930 
                 0.039 
               
               
                   
                 931 
                 0.27 
               
               
                   
                 932 
                 0.0054 
               
               
                   
                 933 
                 0.083 
               
               
                   
                 934 
                 0.034 
               
               
                   
                 935 
                 0.0060 
               
               
                   
                 936 
                 0.0011 
               
               
                   
                 937 
                 0.25 
               
               
                   
                 938 
                 0.00069 
               
               
                   
                 939 
                 0.0080 
               
               
                   
                 940 
                 0.15 
               
               
                   
                 941 
                 0.0033 
               
               
                   
                 942 
                 0.0010 
               
               
                   
                 943 
                 0.00083 
               
               
                   
                 944 
                 0.018 
               
               
                   
                 945 
                 0.0098 
               
               
                   
                 946 
                 0.0075 
               
               
                   
                 947 
                 0.075 
               
               
                   
                 948 
                 0.0031 
               
               
                   
                 949 
                 0.0013 
               
               
                   
                 950 
                 0.0090 
               
               
                   
                 951 
                 0.0079 
               
               
                   
                 952 
                 0.12 
               
               
                   
                 953 
                 0.18 
               
               
                   
                 954 
                 0.0019 
               
               
                   
                 955 
                 0.026 
               
               
                   
                 956 
                 0.080 
               
               
                   
                 957 
                 0.00044 
               
               
                   
                 958 
                 0.0021 
               
               
                   
                 959 
                 0.0014 
               
               
                   
                 960 
                 0.0079 
               
               
                   
                 961 
                 0.012 
               
               
                   
                 962 
                 0.0078 
               
               
                   
                 963 
                 0.013 
               
               
                   
                 964 
                 0.011 
               
               
                   
                 965 
                 0.00086 
               
               
                   
                 966 
                 0.11 
               
               
                   
                 967 
                 0.058 
               
               
                   
                 968 
                 0.0031 
               
               
                   
                 969 
                 0.0020 
               
               
                   
                 970 
                 0.25 
               
               
                   
                 971 
                 0.016 
               
               
                   
                 972 
                 0.33 
               
               
                   
                 973 
                 0.0028 
               
               
                   
                 974 
                 0.00091 
               
               
                   
                 975 
                 0.022 
               
               
                   
                 976 
                 0.18 
               
               
                   
                 977 
                 0.00033 
               
               
                   
                 978 
                 0.17 
               
               
                   
                 979 
                 0.037 
               
               
                   
                 980 
                 0.0038 
               
               
                   
                 981 
                 0.00037 
               
               
                   
                 982 
                 0.048 
               
               
                   
                 983 
                 0.0018 
               
               
                   
                 984 
                 0.025 
               
               
                   
                 985 
                 0.042 
               
               
                   
                 986 
                 0.025 
               
               
                   
                 987 
                 0.00096 
               
               
                   
                 988 
                 0.012 
               
               
                   
                 989 
                 0.034 
               
               
                   
                 990 
                 0.083 
               
               
                   
                 991 
                 0.076 
               
               
                   
                 992 
                 0.18 
               
               
                   
                 993 
                 0.016 
               
               
                   
                 994 
                 0.011 
               
               
                   
                 995 
                 0.0057 
               
               
                   
                 996 
                 0.090 
               
               
                   
                 997 
                 0.024 
               
               
                   
                 998 
                 0.017 
               
               
                   
                 999 
                 0.0017 
               
               
                   
                 1000 
                 0.0026 
               
               
                   
                 1001 
                 0.00044 
               
               
                   
                 1002 
                 0.0021 
               
               
                   
                 1003 
                 0.0084 
               
               
                   
                 1004 
                 0.013 
               
               
                   
                 1005 
                 0.0035 
               
               
                   
                 1006 
                 0.0063 
               
               
                   
                 1007 
                 0.013 
               
               
                   
                 1008 
                 0.00076 
               
               
                   
                 1009 
                 0.043 
               
               
                   
                 1010 
                 0.0043 
               
               
                   
                 1011 
                 0.038 
               
               
                   
                 1012 
                 0.0012 
               
               
                   
                 1013 
                 0.031 
               
               
                   
                 1014 
                 0.013 
               
               
                   
                 1015 
                 0.018 
               
               
                   
                 1016 
                 0.024 
               
               
                   
                 1017 
                 0.00088 
               
               
                   
                 1018 
                 0.011 
               
               
                   
                 1019 
                 0.014 
               
               
                   
                 1020 
                 0.051 
               
               
                   
                 1021 
                 0.24 
               
               
                   
                 1022 
                 0.00042 
               
               
                   
                 1023 
                 0.020 
               
               
                   
                 1024 
                 0.0019 
               
               
                   
                 1025 
                 0.0043 
               
               
                   
                 1026 
                 0.00079 
               
               
                   
                 1027 
                 0.0082 
               
               
                   
                 1029 
                 0.0014 
               
               
                   
                 1030 
                 0.0017 
               
               
                   
                 1031 
                 0.32 
               
               
                   
                 1032 
                 0.060 
               
               
                   
                 1033 
                 0.36 
               
               
                   
                 1034 
                 0.0017 
               
               
                   
                 1035 
                 0.011 
               
               
                   
                 1036 
                 0.0077 
               
               
                   
                 1037 
                 0.00066 
               
               
                   
                 1038 
                 0.018 
               
               
                   
                 1039 
                 0.045 
               
               
                   
                 1040 
                 0.014 
               
               
                   
                 1041 
                 0.0016 
               
               
                   
                 1042 
                 0.00072 
               
               
                   
                 1043 
                 0.060 
               
               
                   
                 1044 
                 0.055 
               
               
                   
                 1045 
                 0.0067 
               
               
                   
                 1046 
                 0.0046 
               
               
                   
                 1047 
                 0.0063 
               
               
                   
                 1048 
                 0.018 
               
               
                   
                 1049 
                 0.0037 
               
               
                   
                 1050 
                 0.049 
               
               
                   
                 1051 
                 0.0029 
               
               
                   
                 1052 
                 0.11 
               
               
                   
                 1053 
                 0.0067 
               
               
                   
                 1054 
                 0.12 
               
               
                   
                 1055 
                 0.0022 
               
               
                   
                 1056 
                 0.018 
               
               
                   
                 1057 
                 0.0012 
               
               
                   
                 1058 
                 0.014 
               
               
                   
                 1059 
                 0.00064 
               
               
                   
                 1060 
                 0.00065 
               
               
                   
                 1061 
                 0.014 
               
               
                   
                 1062 
                 0.00092 
               
               
                   
                 1063 
                 0.043 
               
               
                   
                 1064 
                 0.0043 
               
               
                   
                 1065 
                 0.070 
               
               
                   
                 1066 
                 0.024 
               
               
                   
                 1067 
                 0.29 
               
               
                   
                 1068 
                 0.12 
               
               
                   
                 1069 
                 0.017 
               
               
                   
                 1070 
                 0.00091 
               
               
                   
                 1071 
                 0.0013 
               
               
                   
                 1072 
                 0.0012 
               
               
                   
                 1073 
                 0.0021 
               
               
                   
                 1074 
                 0.011 
               
               
                   
                 1075 
                 0.14 
               
               
                   
                 1076 
                 0.019 
               
               
                   
                 1077 
                 0.034 
               
               
                   
                 1078 
                 0.19 
               
               
                   
                 1079 
                 0.015 
               
               
                   
                 1080 
                 0.0010 
               
               
                   
                 1081 
                 0.025 
               
               
                   
                 1082 
                 0.27 
               
               
                   
                 1083 
                 0.019 
               
               
                   
                 1084 
                 0.053 
               
               
                   
                 1085 
                 0.050 
               
               
                   
                 1086 
                 0.18 
               
               
                   
                 1087 
                 0.015 
               
               
                   
                 1088 
                 0.17 
               
               
                   
                 1089 
                 0.0016 
               
               
                   
                 1090 
                 0.088 
               
               
                   
                 1091 
                 0.0010 
               
               
                   
                 1092 
                 0.041 
               
               
                   
                 1093 
                 0.00073 
               
               
                   
                 1094 
                 0.0022 
               
               
                   
                 1095 
                 0.046 
               
               
                   
                 1096 
                 0.0026 
               
               
                   
                 1097 
                 0.23 
               
               
                   
                 1098 
                 0.0056 
               
               
                   
                 1099 
                 0.00092 
               
               
                   
                 1100 
                 0.0063 
               
               
                   
                 1101 
                 0.0090 
               
               
                   
                 1102 
                 0.16 
               
               
                   
                 1103 
                 0.016 
               
               
                   
                 1104 
                 0.011 
               
               
                   
                 1105 
                 0.021 
               
               
                   
                 1106 
                 0.035 
               
               
                   
                 1107 
                 0.093 
               
               
                   
                 1108 
                 0.011 
               
               
                   
                 1109 
                 0.023 
               
               
                   
                 1110 
                 0.13 
               
               
                   
                 1111 
                 0.041 
               
               
                   
                 1112 
                 0.0060 
               
               
                   
                 1113 
                 0.41 
               
               
                   
                 1114 
                 0.011 
               
               
                   
                 1115 
                 0.0025 
               
               
                   
                 1116 
                 0.00044 
               
               
                   
                 1117 
                 0.0022 
               
               
                   
                 1118 
                 0.20 
               
               
                   
                 1119 
                 0.18 
               
               
                   
                 1120 
                 0.0025 
               
               
                   
                 1121 
                 0.0014 
               
               
                   
                 1122 
                 0.067 
               
               
                   
                 1123 
                 0.18 
               
               
                   
                 1124 
                 0.0070 
               
               
                   
                 1125 
                 0.0025 
               
               
                   
                 1126 
                 0.25 
               
               
                   
                 1127 
                 0.26 
               
               
                   
                 1128 
                 0.0021 
               
               
                   
                 1129 
                 0.15 
               
               
                   
                 1130 
                 0.0044 
               
               
                   
                 1131 
                 0.013 
               
               
                   
                 1132 
                 0.0013 
               
               
                   
                 1133 
                 0.056 
               
               
                   
                 1134 
                 0.0060 
               
               
                   
                 1135 
                 0.0058 
               
               
                   
                 1136 
                 0.070 
               
               
                   
                 1137 
                 0.0046 
               
               
                   
                 1138 
                 0.067 
               
               
                   
                 1139 
                 0.00059 
               
               
                   
                 1140 
                 0.0020 
               
               
                   
                 1141 
                 0.00097 
               
               
                   
                 1142 
                 0.0065 
               
               
                   
                 1143 
                 0.00073 
               
               
                   
                 1144 
                 0.00049 
               
               
                   
                 1145 
                 0.0011 
               
               
                   
                 1146 
                 0.0019 
               
               
                   
                 1148 
                 0.0012 
               
               
                   
                 1149 
                 0.00062 
               
               
                   
                 1150 
                 0.00052 
               
               
                   
                 1151 
                 0.0052 
               
               
                   
                 1152 
                 0.0012 
               
               
                   
                 1153 
                 0.0025 
               
               
                   
                 1154 
                 0.0024 
               
               
                   
                 1155 
                 0.17 
               
               
                   
                 1156 
                 0.14 
               
               
                   
                 1157 
                 0.0016 
               
               
                   
                 1158 
                 0.00052 
               
               
                   
                 1159 
                 0.0028 
               
               
                   
                 1160 
                 0.00042 
               
               
                   
                 1161 
                 0.060 
               
               
                   
                 1162 
                 0.00057 
               
               
                   
                 1163 
                 0.00046 
               
               
                   
                 1164 
                 0.0014 
               
               
                   
                 1165 
                 0.00073 
               
               
                   
                 1166 
                 0.00047 
               
               
                   
                 1167 
                 0.0087 
               
               
                   
                 1168 
                 0.10 
               
               
                   
                 1169 
                 0.053 
               
               
                   
                 1170 
                 0.00054 
               
               
                   
                 1171 
                 0.00099 
               
               
                   
                 1172 
                 0.0068 
               
               
                   
                 1173 
                 0.00074 
               
               
                   
                 1174 
                 0.062 
               
               
                   
                 1175 
                 0.00079 
               
               
                   
                 1176 
                 0.00080 
               
               
                   
                 1177 
                 0.012 
               
               
                   
                 1178 
                 0.0010 
               
               
                   
                 1179 
                 0.00052 
               
               
                   
                 1180 
                 0.00050 
               
               
                   
                 1181 
                 0.0060 
               
               
                   
                 1182 
                 0.00056 
               
               
                   
                 1183 
                 0.00073 
               
               
                   
                 1184 
                 0.13 
               
               
                   
                 1185 
                 0.011 
               
               
                   
                 1186 
                 0.0086 
               
               
                   
                 1187 
                 0.099 
               
               
                   
                 1188 
                 0.033 
               
               
                   
                 1189 
                 0.00074 
               
               
                   
                 1190 
                 0.00083 
               
               
                   
                 1191 
                 0.0067 
               
               
                   
                 1192 
                 0.00039 
               
               
                   
                 1193 
                 0.0021 
               
               
                   
                 1194 
                 0.00052 
               
               
                   
                 1195 
                 0.038 
               
               
                   
                 1196 
                 0.00048 
               
               
                   
                 1197 
                 0.00060 
               
               
                   
                 1198 
                 0.0012 
               
               
                   
                 1199 
                 0.00070 
               
               
                   
                 1200 
                 0.045 
               
               
                   
                 1201 
                 0.00053 
               
               
                   
                 1202 
                 0.24 
               
               
                   
                 1203 
                 0.0021 
               
               
                   
                 1204 
                 0.00044 
               
               
                   
                 1205 
                 0.0028 
               
               
                   
                 1206 
                 0.00057 
               
               
                   
                 1207 
                 0.0027 
               
               
                   
                 1208 
                 0.00069 
               
               
                   
                 1209 
                 0.00085 
               
               
                   
                 1210 
                 0.00074 
               
               
                   
                 1211 
                 0.031 
               
               
                   
                 1212 
                 0.12 
               
               
                   
                 1213 
                 0.017 
               
               
                   
                 1214 
                 0.077 
               
               
                   
                 1215 
                 0.0018 
               
               
                   
                 1216 
                 0.12 
               
               
                   
                 1217 
                 0.0010 
               
               
                   
                 1218 
                 0.0049 
               
               
                   
                 1219 
                 0.016 
               
               
                   
                 1220 
                 0.00064 
               
               
                   
                 1221 
                 0.038 
               
               
                   
                 1222 
                 0.025 
               
               
                   
                 1223 
                 0.0012 
               
               
                   
                 1224 
                 0.00067 
               
               
                   
                 1225 
                 0.034 
               
               
                   
                 1226 
                 0.015 
               
               
                   
                 1227 
                 0.0013 
               
               
                   
                 1228 
                 0.00059 
               
               
                   
                 1229 
                 0.046 
               
               
                   
                 1230 
                 0.098 
               
               
                   
                 1231 
                 0.00059 
               
               
                   
                 1232 
                 0.00047 
               
               
                   
                 1233 
                 0.0025 
               
               
                   
                 1234 
                 0.0045 
               
               
                   
                 1235 
                 0.0055 
               
               
                   
                 1236 
                 0.0073 
               
               
                   
                 1237 
                 0.00086 
               
               
                   
                 1238 
                 0.0099 
               
               
                   
                 1239 
                 0.18 
               
               
                   
                 1240 
                 0.29 
               
               
                   
                 1241 
                 0.00050 
               
               
                   
                 1242 
                 0.00052 
               
               
                   
                 1243 
                 0.027 
               
               
                   
                 1244 
                 0.00063 
               
               
                   
                 1245 
                 0.00054 
               
               
                   
                 1246 
                 0.055 
               
               
                   
                 1247 
                 0.0048 
               
               
                   
                 1248 
                 0.00067 
               
               
                   
                 1249 
                 0.033 
               
               
                   
                 1250 
                 0.00063 
               
               
                   
                 1251 
                 0.0026 
               
               
                   
                 1252 
                 0.0025 
               
               
                   
                 1253 
                 0.00081 
               
               
                   
                 1254 
                 0.00054 
               
               
                   
                 1255 
                 0.0014 
               
               
                   
                 1256 
                 0.0091 
               
               
                   
                 1257 
                 0.0065 
               
               
                   
                 1258 
                 0.026 
               
               
                   
                 1259 
                 0.00049 
               
               
                   
                 1260 
                 0.00054 
               
               
                   
                 1261 
                 0.00065 
               
               
                   
                 1262 
                 0.0013 
               
               
                   
                 1263 
                 0.0027 
               
               
                   
                 1264 
                 0.00054 
               
               
                   
                 1265 
                 0.28 
               
               
                   
                 1266 
                 0.0012 
               
               
                   
                 1267 
                 0.00036 
               
               
                   
                 1268 
                 0.019 
               
               
                   
                 1269 
                 0.0010 
               
               
                   
                 1270 
                 0.00061 
               
               
                   
                 1271 
                 0.00049 
               
               
                   
                 1272 
                 0.0020 
               
               
                   
                 1273 
                 0.0072 
               
               
                   
                 1274 
                 0.0038 
               
               
                   
                 1275 
                 0.00065 
               
               
                   
                 1276 
                 0.017 
               
               
                   
                 1277 
                 0.0067 
               
               
                   
                 1278 
                 0.00065 
               
               
                   
                 1279 
                 0.016 
               
               
                   
                 1280 
                 0.074 
               
               
                   
                 1281 
                 0.00042 
               
               
                   
                 1282 
                 0.00081 
               
               
                   
                 1283 
                 0.00063 
               
               
                   
                 1284 
                 0.00069 
               
               
                   
                 1285 
                 0.00053 
               
               
                   
                 1286 
                 0.024 
               
               
                   
                 1287 
                 0.0011 
               
               
                   
                 1288 
                 0.031 
               
               
                   
                 1289 
                 0.00067 
               
               
                   
                 1290 
                 0.00063 
               
               
                   
                 1291 
                 0.0054 
               
               
                   
                 1292 
                 0.0020 
               
               
                   
                 1293 
                 0.00096 
               
               
                   
                 1294 
                 0.050 
               
               
                   
                 1295 
                 0.00050 
               
               
                   
                 1296 
                 0.00059 
               
               
                   
                 1297 
                 0.00051 
               
               
                   
                 1298 
                 0.028 
               
               
                   
                 1299 
                 0.0036 
               
               
                   
                 1300 
                 0.094 
               
               
                   
                 1301 
                 0.00067 
               
               
                   
                 1302 
                 0.00075 
               
               
                   
                 1303 
                 0.00072 
               
               
                   
                 1304 
                 0.085 
               
               
                   
                 1305 
                 0.24 
               
               
                   
                 1306 
                 0.00050 
               
               
                   
                 1307 
                 0.0027 
               
               
                   
                 1308 
                 0.00065 
               
               
                   
                 1309 
                 0.00085 
               
               
                   
                 1310 
                 0.00087 
               
               
                   
                 1311 
                 0.00051 
               
               
                   
                 1312 
                 0.00074 
               
               
                   
                 1313 
                 0.065 
               
               
                   
                 1314 
                 0.090 
               
               
                   
                 1315 
                 0.0010 
               
               
                   
                 1316 
                 0.0032 
               
               
                   
                 1317 
                 0.00057 
               
               
                   
                 1318 
                 0.078 
               
               
                   
                 1319 
                 0.00082 
               
               
                   
                 1320 
                 0.0014 
               
               
                   
                 1321 
                 0.00055 
               
               
                   
                 1322 
                 0.00082 
               
               
                   
                 1323 
                 0.0043 
               
               
                   
                 1324 
                 0.0012 
               
               
                   
                 1325 
                 0.00096 
               
               
                   
                 1326 
                 0.0051 
               
               
                   
                 1327 
                 0.072 
               
               
                   
                 1328 
                 0.22 
               
               
                   
                 1329 
                 0.0017 
               
               
                   
                 1330 
                 0.00062 
               
               
                   
                 1331 
                 0.0011 
               
               
                   
                 1332 
                 0.023 
               
               
                   
                 1333 
                 0.00048 
               
               
                   
                 1334 
                 0.0030 
               
               
                   
                 1335 
                 0.00049 
               
               
                   
                 1336 
                 0.00066 
               
               
                   
                 1337 
                 0.00055 
               
               
                   
                 1338 
                 0.017 
               
               
                   
                 1339 
                 0.00057 
               
               
                   
                 1340 
                 0.0012 
               
               
                   
                 1341 
                 0.00082 
               
               
                   
                 1342 
                 0.00053 
               
               
                   
                 1343 
                 0.00061 
               
               
                   
                 1344 
                 0.19 
               
               
                   
                 1345 
                 0.040 
               
               
                   
                 1346 
                 0.00060 
               
               
                   
                 1347 
                 0.0013 
               
               
                   
                 1348 
                 0.00062 
               
               
                   
                 1349 
                 0.15 
               
               
                   
                 1350 
                 0.017 
               
               
                   
                 1351 
                 0.00082 
               
               
                   
                 1352 
                 0.11 
               
               
                   
                 1353 
                 0.011 
               
               
                   
                 1354 
                 0.0077 
               
               
                   
                 1355 
                 0.0032 
               
               
                   
                 1356 
                 0.0011 
               
               
                   
                 1357 
                 0.00052 
               
               
                   
                 1358 
                 0.019 
               
               
                   
                 1359 
                 0.0062 
               
               
                   
                 1360 
                 0.00097 
               
               
                   
                 1361 
                 0.024 
               
               
                   
                 1362 
                 0.00081 
               
               
                   
                 1363 
                 0.00057 
               
               
                   
                 1364 
                 0.0012 
               
               
                   
                 1365 
                 0.0012 
               
               
                   
                 1366 
                 0.00063 
               
               
                   
                 1367 
                 0.00065 
               
               
                   
                 1368 
                 0.00067 
               
               
                   
                 1369 
                 0.00055 
               
               
                   
                 1370 
                 0.00060 
               
               
                   
                 1371 
                 0.0016 
               
               
                   
                 1372 
                 0.017 
               
               
                   
                 1373 
                 0.0077 
               
               
                   
                 1374 
                 0.00054 
               
               
                   
                 1375 
                 0.0093 
               
               
                   
                 1376 
                 0.00071 
               
               
                   
                 1377 
                 0.0058 
               
               
                   
                 1378 
                 0.38 
               
               
                   
                 1379 
                 0.064 
               
               
                   
                 1380 
                 0.016 
               
               
                   
                 1381 
                 0.15 
               
               
                   
                 1382 
                 0.23 
               
               
                   
                 1383 
                 0.13 
               
               
                   
                 1384 
                 0.23 
               
               
                   
                 1385 
                 0.20 
               
               
                   
                 1386 
                 0.0100 
               
               
                   
                 1387 
                 0.014 
               
               
                   
                 1388 
                 0.010 
               
               
                   
                 1389 
                 0.24 
               
               
                   
                 1390 
                 0.28 
               
               
                   
                 1391 
                 0.065 
               
               
                   
                 1392 
                 0.028 
               
               
                   
                 1393 
                 0.38 
               
               
                   
                 1394 
                 0.13 
               
               
                   
                 1395 
                 0.27 
               
               
                   
                 1396 
                 0.016 
               
               
                   
                 1397 
                 0.0064 
               
               
                   
                 1398 
                 0.0066 
               
               
                   
                 1399 
                 0.070 
               
               
                   
                 1400 
                 0.21 
               
               
                   
                 1401 
                 0.12 
               
               
                   
                 1402 
                 0.057 
               
               
                   
                 1403 
                 0.032 
               
               
                   
                 1404 
                 0.017 
               
               
                   
                 1405 
                 0.082 
               
               
                   
                 1406 
                 0.16 
               
               
                   
                 1407 
                 0.17 
               
               
                   
                 1408 
                 0.16 
               
               
                   
                 1409 
                 0.17 
               
               
                   
                 1410 
                 0.27 
               
               
                   
                 1411 
                 0.082 
               
               
                   
                 1412 
                 0.31 
               
               
                   
                 1413 
                 0.19 
               
               
                   
                 1414 
                 0.038 
               
               
                   
                 1415 
                 0.034 
               
               
                   
                 1416 
                 0.097 
               
               
                   
                 1417 
                 0.029 
               
               
                   
                 1418 
                 0.11 
               
               
                   
                 1419 
                 0.046 
               
               
                   
                 1420 
                 0.089 
               
               
                   
                 1421 
                 0.032 
               
               
                   
                 1422 
                 0.016 
               
               
                   
                 1423 
                 0.19 
               
               
                   
                 1424 
                 0.20 
               
               
                   
                 1425 
                 0.019 
               
               
                   
                 1426 
                 0.048 
               
               
                   
                 1427 
                 0.25 
               
               
                   
                 1428 
                 0.042 
               
               
                   
                 1429 
                 0.044 
               
               
                   
                 1430 
                 0.40 
               
               
                   
                 1431 
                 0.22 
               
               
                   
                 1432 
                 0.26 
               
               
                   
                 1433 
                 0.029 
               
               
                   
                 1434 
                 0.15 
               
               
                   
                 1435 
                 0.0074 
               
               
                   
                 1436 
                 0.039 
               
               
                   
                 1437 
                 0.081 
               
               
                   
                 1438 
                 0.036 
               
               
                   
                 1439 
                 0.0037 
               
               
                   
                 1440 
                 0.016 
               
               
                   
                 1441 
                 0.0064 
               
               
                   
                 1442 
                 0.28 
               
               
                   
                 1443 
                 0.023 
               
               
                   
                 1444 
                 0.0088 
               
               
                   
                 1445 
                 0.25 
               
               
                   
                 1446 
                 0.15 
               
               
                   
                 1447 
                 0.10 
               
               
                   
                 1448 
                 0.0011 
               
               
                   
                 1449 
                 0.014 
               
               
                   
                 1450 
                 0.22 
               
               
                   
                 1451 
                 0.020 
               
               
                   
                 1452 
                 0.038 
               
               
                   
                 1453 
                 0.11 
               
               
                   
                 1454 
                 0.011 
               
               
                   
                 1455 
                 0.030 
               
               
                   
                 1456 
                 0.012 
               
               
                   
                 1457 
                 0.011 
               
               
                   
                 1458 
                 0.0072 
               
               
                   
                 1459 
                 0.29 
               
               
                   
                 1460 
                 0.13 
               
               
                   
                 1461 
                 0.037 
               
               
                   
                 1462 
                 0.00079 
               
               
                   
                 1463 
                 0.00068 
               
               
                   
                 1464 
                 0.19 
               
               
                   
                 1465 
                 0.051 
               
               
                   
                 1466 
                 0.0010 
               
               
                   
                 1467 
                 0.12 
               
               
                   
                 1468 
                 0.090 
               
               
                   
                 1469 
                 0.23 
               
               
                   
                 1470 
                 0.21 
               
               
                   
                 1471 
                 0.0017 
               
               
                   
                 1472 
                 0.067 
               
               
                   
                 1473 
                 0.39 
               
               
                   
                 1474 
                 0.24 
               
               
                   
                 1475 
                 0.0027 
               
               
                   
                 1476 
                 0.046 
               
               
                   
                 1477 
                 0.028 
               
               
                   
                 1478 
                 0.0030 
               
               
                   
                 1479 
                 0.12 
               
               
                   
                 1480 
                 0.0089 
               
               
                   
                 1481 
                 0.0050 
               
               
                   
                 1482 
                 0.088 
               
               
                   
                 1483 
                 0.034 
               
               
                   
                 1484 
                 0.19 
               
               
                   
                 1485 
                 0.00084 
               
               
                   
                 1486 
                 0.00050 
               
               
                   
                 1487 
                 0.34 
               
               
                   
                 1488 
                 0.26 
               
               
                   
                 1489 
                 0.018 
               
               
                   
                 1490 
                 0.32 
               
               
                   
                 1491 
                 0.0037 
               
               
                   
                 1492 
                 0.24 
               
               
                   
                 1493 
                 0.10 
               
               
                   
                 1494 
                 0.14 
               
               
                   
                 1495 
                 0.12 
               
               
                   
                 1496 
                 0.0020 
               
               
                   
                 1497 
                 0.025 
               
               
                   
                 1498 
                 0.0017 
               
               
                   
                 1499 
                 0.019 
               
               
                   
                 1500 
                 0.0039 
               
               
                   
                 1501 
                 0.014 
               
               
                   
                 1502 
                 0.024 
               
               
                   
                 1503 
                 0.016 
               
               
                   
                 1504 
                 0.057 
               
               
                   
                 1505 
                 0.22 
               
               
                   
                 1506 
                 0.0029 
               
               
                   
                 1507 
                 0.024 
               
               
                   
                 1508 
                 0.0013 
               
               
                   
                 1509 
                 0.023 
               
               
                   
                 1510 
                 0.11 
               
               
                   
                 1511 
                 0.19 
               
               
                   
                 1512 
                 0.0012 
               
               
                   
                 1513 
                 0.27 
               
               
                   
                 1514 
                 0.0010 
               
               
                   
                 1515 
                 0.077 
               
               
                   
                 1516 
                 0.34 
               
               
                   
                 1517 
                 0.049 
               
               
                   
                 1518 
                 0.37 
               
               
                   
                 1519 
                 0.12 
               
               
                   
                 1520 
                 0.059 
               
               
                   
                 1521 
                 0.11 
               
               
                   
                 1522 
                 0.090 
               
               
                   
                 1523 
                 0.00075 
               
               
                   
                 1524 
                 0.0019 
               
               
                   
                 1525 
                 0.10 
               
               
                   
                 1526 
                 0.10 
               
               
                   
                 1527 
                 0.19 
               
               
                   
                 1528 
                 0.041 
               
               
                   
                 1529 
                 0.011 
               
               
                   
                 1530 
                 0.13 
               
               
                   
                 1531 
                 0.23 
               
               
                   
                 1532 
                 0.0048 
               
               
                   
                 1533 
                 0.068 
               
               
                   
                 1534 
                 0.062 
               
               
                   
                 1535 
                 0.041 
               
               
                   
                 1536 
                 0.021 
               
               
                   
                 1537 
                 0.0039 
               
               
                   
                 1538 
                 0.11 
               
               
                   
                 1539 
                 0.054 
               
               
                   
                 1540 
                 0.23 
               
               
                   
                 1541 
                 0.0040 
               
               
                   
                 1542 
                 0.17 
               
               
                   
                 1543 
                 0.16 
               
               
                   
                 1544 
                 0.0056 
               
               
                   
                 1545 
                 0.042 
               
               
                   
                 1546 
                 0.040 
               
               
                   
                 1547 
                 0.022 
               
               
                   
                 1548 
                 0.14 
               
               
                   
                 1549 
                 0.0036 
               
               
                   
                 1550 
                 0.019 
               
               
                   
                 1551 
                 0.0049 
               
               
                   
                 1552 
                 0.061 
               
               
                   
                 1553 
                 0.012 
               
               
                   
                 1554 
                 0.20 
               
               
                   
                 1555 
                 0.0061 
               
               
                   
                 1556 
                 0.017 
               
               
                   
                 1557 
                 0.0057 
               
               
                   
                 1558 
                 0.071 
               
               
                   
                 1559 
                 0.028 
               
               
                   
                 1560 
                 0.16 
               
               
                   
                 1561 
                 0.033 
               
               
                   
                 1562 
                 0.0048 
               
               
                   
                 1563 
                 0.0062 
               
               
                   
                 1564 
                 0.038 
               
               
                   
                 1565 
                 0.014 
               
               
                   
                 1566 
                 0.020 
               
               
                   
                 1567 
                 0.033 
               
               
                   
                 1568 
                 0.094 
               
               
                   
                 1569 
                 0.016 
               
               
                   
                 1570 
                 0.0043 
               
               
                   
                 1571 
                 0.0048 
               
               
                   
                 1572 
                 0.0098 
               
               
                   
                 1573 
                 0.057 
               
               
                   
                 1574 
                 0.035 
               
               
                   
                 1575 
                 0.045 
               
               
                   
                 1576 
                 0.0051 
               
               
                   
                 1577 
                 0.050 
               
               
                   
                 1578 
                 0.028 
               
               
                   
                 1579 
                 0.0082 
               
               
                   
                 1580 
                 0.011 
               
               
                   
                 1581 
                 0.23 
               
               
                   
                 1582 
                 0.035 
               
               
                   
                 1583 
                 0.012 
               
               
                   
                 1584 
                 0.0095 
               
               
                   
                 1585 
                 0.043 
               
               
                   
                 1586 
                 0.059 
               
               
                   
                 1587 
                 0.031 
               
               
                   
                 1588 
                 0.0041 
               
               
                   
                 1589 
                 0.039 
               
               
                   
                 1590 
                 0.0032 
               
               
                   
                 1591 
                 0.097 
               
               
                   
                 1592 
                 0.21 
               
               
                   
                 1593 
                 0.14 
               
               
                   
                 1594 
                 0.0032 
               
               
                   
                 1595 
                 0.015 
               
               
                   
                 1596 
                 0.023 
               
               
                   
                 1597 
                 0.011 
               
               
                   
                 1598 
                 0.0092 
               
               
                   
                 1599 
                 0.017 
               
               
                   
                 1600 
                 0.31 
               
               
                   
                 1601 
                 0.022 
               
               
                   
                 1602 
                 0.0063 
               
               
                   
                 1603 
                 0.094 
               
               
                   
                 1604 
                 0.0058 
               
               
                   
                 1605 
                 0.012 
               
               
                   
                 1606 
                 0.015 
               
               
                   
                 1607 
                 0.028 
               
               
                   
                 1608 
                 0.0058 
               
               
                   
                 1609 
                 0.0053 
               
               
                   
                 1610 
                 0.0067 
               
               
                   
                 1611 
                 0.0032 
               
               
                   
                 1612 
                 0.39 
               
               
                   
                 1613 
                 0.11 
               
               
                   
                 1614 
                 0.051 
               
               
                   
                 1615 
                 0.040 
               
               
                   
                 1616 
                 0.012 
               
               
                   
                 1617 
                 0.0027 
               
               
                   
                 1618 
                 0.29 
               
               
                   
                 1619 
                 0.36 
               
               
                   
                 1620 
                 0.0054 
               
               
                   
                 1621 
                 0.0072 
               
               
                   
                 1622 
                 0.13 
               
               
                   
                 1623 
                 0.054 
               
               
                   
                 1624 
                 0.092 
               
               
                   
                 1625 
                 0.0072 
               
               
                   
                 1626 
                 0.0044 
               
               
                   
                 1627 
                 0.015 
               
               
                   
                 1628 
                 0.067 
               
               
                   
                 1629 
                 0.0025 
               
               
                   
                 1630 
                 0.0062 
               
               
                   
                 1631 
                 0.0050 
               
               
                   
                 1632 
                 0.0029 
               
               
                   
                 1633 
                 0.050 
               
               
                   
                 1634 
                 0.013 
               
               
                   
                 1635 
                 0.14 
               
               
                   
                 1636 
                 0.011 
               
               
                   
                 1637 
                 0.017 
               
               
                   
                 1638 
                 0.0073 
               
               
                   
                 1639 
                 0.0058 
               
               
                   
                 1640 
                 0.0066 
               
               
                   
                 1641 
                 0.0083 
               
               
                   
                 1642 
                 0.058 
               
               
                   
                 1643 
                 0.0072 
               
               
                   
                 1644 
                 0.0031 
               
               
                   
                 1645 
                 0.0010 
               
               
                   
                 1646 
                 0.0046 
               
               
                   
                 1647 
                 0.0030 
               
               
                   
                 1648 
                 0.010 
               
               
                   
                 1649 
                 0.00042 
               
               
                   
                 1650 
                 0.0026 
               
               
                   
                 1651 
                 0.0049 
               
               
                   
                 1652 
                 0.0031 
               
               
                   
                 1653 
                 0.00089 
               
               
                   
                 1654 
                 0.022 
               
               
                   
                 1655 
                 0.085 
               
               
                   
                 1656 
                 0.0014 
               
               
                   
                 1657 
                 0.0028 
               
               
                   
                 1658 
                 0.00055 
               
               
                   
                 1659 
                 0.00038 
               
               
                   
                 1660 
                 0.016 
               
               
                   
                 1661 
                 0.0027 
               
               
                   
                 1662 
                 0.00065 
               
               
                   
                 1663 
                 0.0016 
               
               
                   
                 1664 
                 0.0088 
               
               
                   
                 1665 
                 0.019 
               
               
                   
                 1666 
                 0.0011 
               
               
                   
                 1667 
                 0.013 
               
               
                   
                 1668 
                 0.00085 
               
               
                   
                 1669 
                 0.0018 
               
               
                   
                 1670 
                 0.0010 
               
               
                   
                 1671 
                 0.0011 
               
               
                   
                 1672 
                 0.0043 
               
               
                   
                 1673 
                 0.0054 
               
               
                   
                 1674 
                 0.058 
               
               
                   
                 1675 
                 0.0012 
               
               
                   
                 1676 
                 0.0016 
               
               
                   
                 1677 
                 0.0086 
               
               
                   
                 1678 
                 0.026 
               
               
                   
                 1679 
                 0.00085 
               
               
                   
                 1680 
                 0.00061 
               
               
                   
                 1681 
                 0.0031 
               
               
                   
                 1682 
                 0.0024 
               
               
                   
                 1683 
                 0.052 
               
               
                   
                 1684 
                 0.0043 
               
               
                   
                 1685 
                 0.00060 
               
               
                   
                 1686 
                 0.0015 
               
               
                   
                 1687 
                 0.0042 
               
               
                   
                 1688 
                 0.024 
               
               
                   
                 1689 
                 0.0011 
               
               
                   
                 1690 
                 0.097 
               
               
                   
                 1691 
                 0.12 
               
               
                   
                 1692 
                 0.0035 
               
               
                   
                 1693 
                 0.0017 
               
               
                   
                 1694 
                 0.00055 
               
               
                   
                 1695 
                 0.0080 
               
               
                   
                 1696 
                 0.00057 
               
               
                   
                 1697 
                 0.11 
               
               
                   
                 1698 
                 0.0012 
               
               
                   
                 1699 
                 0.0011 
               
               
                   
                 1700 
                 0.00066 
               
               
                   
                 1701 
                 0.00075 
               
               
                   
                 1702 
                 0.031 
               
               
                   
                 1703 
                 0.00041 
               
               
                   
                 1704 
                 0.0060 
               
               
                   
                 1705 
                 0.0098 
               
               
                   
                 1706 
                 0.14 
               
               
                   
                 1707 
                 0.18 
               
               
                   
                 1708 
                 0.010 
               
               
                   
                 1709 
                 0.010 
               
               
                   
                 1710 
                 0.33 
               
               
                   
                 1711 
                 0.00078 
               
               
                   
                 1712 
                 0.0098 
               
               
                   
                 1713 
                 0.00049 
               
               
                   
                 1714 
                 0.0023 
               
               
                   
                 1715 
                 0.0024 
               
               
                   
                 1716 
                 0.0079 
               
               
                   
                 1717 
                 0.0033 
               
               
                   
                 1718 
                 0.00080 
               
               
                   
                 1719 
                 0.018 
               
               
                   
                 1720 
                 0.00058 
               
               
                   
                 1721 
                 0.022 
               
               
                   
                 1722 
                 0.0028 
               
               
                   
                 1723 
                 0.0036 
               
               
                   
                 1724 
                 0.016 
               
               
                   
                 1725 
                 0.023 
               
               
                   
                 1726 
                 0.00068 
               
               
                   
                 1727 
                 0.0012 
               
               
                   
                 1728 
                 0.0012 
               
               
                   
                 1729 
                 0.00044 
               
               
                   
                 1730 
                 0.035 
               
               
                   
                 1731 
                 0.0019 
               
               
                   
                 1732 
                 0.0055 
               
               
                   
                 1733 
                 0.13 
               
               
                   
                 1734 
                 0.071 
               
               
                   
                 1735 
                 0.0011 
               
               
                   
                 1736 
                 0.0043 
               
               
                   
                 1737 
                 0.0083 
               
               
                   
                 1738 
                 0.011 
               
               
                   
                 1739 
                 0.0047 
               
               
                   
                 1740 
                 0.00079 
               
               
                   
                 1741 
                 0.0038 
               
               
                   
                 1742 
                 0.020 
               
               
                   
                 1743 
                 0.0013 
               
               
                   
                 1744 
                 0.0040 
               
               
                   
                 1745 
                 0.0013 
               
               
                   
                 1746 
                 0.00089 
               
               
                   
                 1747 
                 0.016 
               
               
                   
                 1748 
                 0.00061 
               
               
                   
                 1749 
                 0.00074 
               
               
                   
                 1750 
                 0.0013 
               
               
                   
                 1751 
                 0.0073 
               
               
                   
                 1752 
                 0.017 
               
               
                   
                 1753 
                 0.0025 
               
               
                   
                 1754 
                 0.067 
               
               
                   
                 1755 
                 0.0079 
               
               
                   
                 1756 
                 0.00054 
               
               
                   
                 1757 
                 0.00043 
               
               
                   
                 1758 
                 0.0012 
               
               
                   
                 1759 
                 0.0027 
               
               
                   
                 1760 
                 0.032 
               
               
                   
                 1761 
                 0.00041 
               
               
                   
                 1762 
                 0.00037 
               
               
                   
                 1763 
                 0.0045 
               
               
                   
                 1764 
                 0.0032 
               
               
                   
                 1765 
                 0.074 
               
               
                   
                 1766 
                 0.0036 
               
               
                   
                 1767 
                 0.0072 
               
               
                   
                 1768 
                 0.14 
               
               
                   
                 1769 
                 0.011 
               
               
                   
                 1770 
                 0.00071 
               
               
                   
                 1771 
                 0.078 
               
               
                   
                 1772 
                 0.00075 
               
               
                   
                 1773 
                 0.051 
               
               
                   
                 1774 
                 0.00084 
               
               
                   
                 1775 
                 0.0040 
               
               
                   
                 1776 
                 0.024 
               
               
                   
                 1777 
                 0.00063 
               
               
                   
                 1778 
                 0.0073 
               
               
                   
                 1779 
                 0.00052 
               
               
                   
                 1780 
                 0.12 
               
               
                   
                 1781 
                 0.049 
               
               
                   
                 1782 
                 0.0022 
               
               
                   
                 1783 
                 0.052 
               
               
                   
                 1784 
                 0.011 
               
               
                   
                 1785 
                 0.00045 
               
               
                   
                 1786 
                 0.00072 
               
               
                   
                 1787 
                 0.0011 
               
               
                   
                 1788 
                 0.0043 
               
               
                   
                 1789 
                 0.0065 
               
               
                   
                 1790 
                 0.00070 
               
               
                   
                 1791 
                 0.0030 
               
               
                   
                 1792 
                 0.00092 
               
               
                   
                 1793 
                 0.0019 
               
               
                   
                 1794 
                 0.040 
               
               
                   
                 1795 
                 0.00099 
               
               
                   
                 1796 
                 0.00076 
               
               
                   
                 1797 
                 0.0037 
               
               
                   
                 1798 
                 0.0010 
               
               
                   
                 1799 
                 0.015 
               
               
                   
                 1800 
                 0.011 
               
               
                   
                 1801 
                 0.0029 
               
               
                   
                 1802 
                 0.021 
               
               
                   
                 1803 
                 0.0053 
               
               
                   
                 1804 
                 0.00051 
               
               
                   
                 1805 
                 0.00092 
               
               
                   
                 1806 
                 0.014 
               
               
                   
                 1807 
                 0.00089 
               
               
                   
                 1808 
                 0.047 
               
               
                   
                 1809 
                 0.0014 
               
               
                   
                 1810 
                 0.00065 
               
               
                   
                 1811 
                 0.056 
               
               
                   
                 1812 
                 0.00056 
               
               
                   
                 1813 
                 0.036 
               
               
                   
                 1814 
                 0.17 
               
               
                   
                 1815 
                 0.0025 
               
               
                   
                 1816 
                 0.012 
               
               
                   
                 1817 
                 0.0014 
               
               
                   
                 1818 
                 0.00040 
               
               
                   
                 1819 
                 0.0038 
               
               
                   
                 1820 
                 0.014 
               
               
                   
                 1821 
                 0.00099 
               
               
                   
                 1822 
                 0.050 
               
               
                   
                 1823 
                 0.059 
               
               
                   
                 1824 
                 0.00075 
               
               
                   
                 1825 
                 0.0034 
               
               
                   
                 1826 
                 0.099 
               
               
                   
                 1827 
                 0.0066 
               
               
                   
                 1828 
                 0.0027 
               
               
                   
                 1829 
                 0.0015 
               
               
                   
                 1830 
                 0.0016 
               
               
                   
                 1831 
                 0.071 
               
               
                   
                 1832 
                 0.0010 
               
               
                   
                 1833 
                 0.0075 
               
               
                   
                 1834 
                 0.00081 
               
               
                   
                 1835 
                 0.0011 
               
               
                   
                 1836 
                 0.00047 
               
               
                   
                 1837 
                 0.0020 
               
               
                   
                 1838 
                 0.0026 
               
               
                   
                 1839 
                 0.055 
               
               
                   
                 1840 
                 0.0012 
               
               
                   
                 1841 
                 0.0044 
               
               
                   
                 1842 
                 0.00066 
               
               
                   
                 1843 
                 0.00084 
               
               
                   
                 1844 
                 0.017 
               
               
                   
                 1845 
                 0.00084 
               
               
                   
                 1846 
                 0.0011 
               
               
                   
                 1847 
                 0.00063 
               
               
                   
                 1848 
                 0.0014 
               
               
                   
                 1849 
                 0.23 
               
               
                   
                 1850 
                 0.00060 
               
               
                   
                 1851 
                 0.0025 
               
               
                   
                 1852 
                 0.00094 
               
               
                   
                 1853 
                 0.0089 
               
               
                   
                 1854 
                 0.0055 
               
               
                   
                 1855 
                 0.34 
               
               
                   
                 1856 
                 0.0054 
               
               
                   
                 1857 
                 0.019 
               
               
                   
                 1858 
                 0.0011 
               
               
                   
                 1859 
                 0.015 
               
               
                   
                 1860 
                 0.011 
               
               
                   
                 1861 
                 0.0013 
               
               
                   
                 1862 
                 0.0020 
               
               
                   
                 1863 
                 0.010 
               
               
                   
                 1864 
                 0.048 
               
               
                   
                 1865 
                 0.00043 
               
               
                   
                 1866 
                 0.0028 
               
               
                   
                 1867 
                 0.00073 
               
               
                   
                 1868 
                 0.10 
               
               
                   
                 1869 
                 0.00076 
               
               
                   
                 1870 
                 0.00074 
               
               
                   
                 1871 
                 0.00048 
               
               
                   
                 1872 
                 0.00065 
               
               
                   
                 1873 
                 0.033 
               
               
                   
                 1874 
                 0.40 
               
               
                   
                 1875 
                 0.00042 
               
               
                   
                 1876 
                 0.098 
               
               
                   
                 1877 
                 0.00086 
               
               
                   
                 1878 
                 0.0088 
               
               
                   
                 1879 
                 0.00066 
               
               
                   
                 1880 
                 0.013 
               
               
                   
                 1881 
                 0.0014 
               
               
                   
                 1882 
                 0.0097 
               
               
                   
                 1883 
                 0.065 
               
               
                   
                 1884 
                 0.00041 
               
               
                   
                 1885 
                 0.032 
               
               
                   
                 1886 
                 0.00093 
               
               
                   
                 1887 
                 0.18 
               
               
                   
                 1888 
                 0.053 
               
               
                   
                 1889 
                 0.098 
               
               
                   
                 1890 
                 0.00055 
               
               
                   
                 1891 
                 0.23 
               
               
                   
                 1892 
                 0.0015 
               
               
                   
                 1893 
                 0.014 
               
               
                   
                 1894 
                 0.00055 
               
               
                   
                 1895 
                 0.36 
               
               
                   
                 1896 
                 0.00049 
               
               
                   
                 1897 
                 0.0099 
               
               
                   
                 1898 
                 0.00093 
               
               
                   
                 1899 
                 0.22 
               
               
                   
                 1900 
                 0.00099 
               
               
                   
                 1901 
                 0.00056 
               
               
                   
                 1902 
                 0.054 
               
               
                   
                 1903 
                 0.0040 
               
               
                   
                 1904 
                 0.00057 
               
               
                   
                 1905 
                 0.00033 
               
               
                   
                 1906 
                 0.00055 
               
               
                   
                 1907 
                 0.0013 
               
               
                   
                 1908 
                 0.00065 
               
               
                   
                 1909 
                 0.11 
               
               
                   
                 1910 
                 0.060 
               
               
                   
                 1911 
                 0.00067 
               
               
                   
                 1912 
                 0.027 
               
               
                   
                 1913 
                 0.0011 
               
               
                   
                 1914 
                 0.0077 
               
               
                   
                 1915 
                 0.00038 
               
               
                   
                 1916 
                 0.00099 
               
               
                   
                 1917 
                 0.028 
               
               
                   
                 1918 
                 0.28 
               
               
                   
                 1919 
                 0.21 
               
               
                   
                 1920 
                 0.021 
               
               
                   
                 1921 
                 0.00083 
               
               
                   
                 1922 
                 0.0031 
               
               
                   
                 1923 
                 0.00089 
               
               
                   
                 1924 
                 0.0051 
               
               
                   
                 1925 
                 0.00055 
               
               
                   
                 1926 
                 0.021 
               
               
                   
                 1927 
                 0.0033 
               
               
                   
                 1928 
                 0.00050 
               
               
                   
                 1929 
                 0.00061 
               
               
                   
                 1930 
                 0.0036 
               
               
                   
                 1931 
                 0.00056 
               
               
                   
                 1932 
                 0.0011 
               
               
                   
                 1933 
                 0.00059 
               
               
                   
                 1934 
                 0.0010 
               
               
                   
                 1935 
                 0.011 
               
               
                   
                 1936 
                 0.00068 
               
               
                   
                 1937 
                 0.0031 
               
               
                   
                 1938 
                 0.00076 
               
               
                   
                 1939 
                 0.00071 
               
               
                   
                 1940 
                 0.0016 
               
               
                   
                 1941 
                 0.0015 
               
               
                   
                 1942 
                 0.29 
               
               
                   
                 1943 
                 0.0080 
               
               
                   
                 1944 
                 0.045 
               
               
                   
                 1945 
                 0.018 
               
               
                   
                 1946 
                 0.0015 
               
               
                   
                 1947 
                 0.0012 
               
               
                   
                 1948 
                 0.00054 
               
               
                   
                 1949 
                 0.00060 
               
               
                   
                 1950 
                 0.0028 
               
               
                   
                 1951 
                 0.0099 
               
               
                   
                 1952 
                 0.0081 
               
               
                   
                 1953 
                 0.051 
               
               
                   
                 1954 
                 0.0023 
               
               
                   
                 1955 
                 0.0015 
               
               
                   
                 1956 
                 0.00076 
               
               
                   
                 1957 
                 0.0012 
               
               
                   
                 1958 
                 0.00045 
               
               
                   
                 1959 
                 0.0052 
               
               
                   
                 1960 
                 0.056 
               
               
                   
                 1961 
                 0.0018 
               
               
                   
                 1962 
                 0.0014 
               
               
                   
                 1963 
                 0.00063 
               
               
                   
                 1964 
                 0.036 
               
               
                   
                 1965 
                 0.00055 
               
               
                   
                 1966 
                 0.00092 
               
               
                   
                 1967 
                 0.077 
               
               
                   
                 1968 
                 0.0012 
               
               
                   
                 1969 
                 0.00061 
               
               
                   
                 1970 
                 0.052 
               
               
                   
                 1971 
                 0.0011 
               
               
                   
                 1972 
                 0.00037 
               
               
                   
                 1973 
                 0.0071 
               
               
                   
                 1974 
                 0.045 
               
               
                   
                 1975 
                 0.00051 
               
               
                   
                 1976 
                 0.0015 
               
               
                   
                 1977 
                 0.00047 
               
               
                   
                 1978 
                 0.00051 
               
               
                   
                 1979 
                 0.00064 
               
               
                   
                 1980 
                 0.0015 
               
               
                   
                 1981 
                 0.0051 
               
               
                   
                 1982 
                 0.047 
               
               
                   
                 1983 
                 0.00068 
               
               
                   
                 1984 
                 0.00038 
               
               
                   
                 1985 
                 0.00070 
               
               
                   
                 1986 
                 0.011 
               
               
                   
                 1987 
                 0.015 
               
               
                   
                 1988 
                 0.00069 
               
               
                   
                 1989 
                 0.46 
               
               
                   
                 1990 
                 0.00043 
               
               
                   
                 1991 
                 0.0092 
               
               
                   
                 1992 
                 0.28 
               
               
                   
                 1993 
                 0.00064 
               
               
                   
                 1994 
                 0.00058 
               
               
                   
                 1995 
                 0.34 
               
               
                   
                 1996 
                 0.00064 
               
               
                   
                 1997 
                 0.22 
               
               
                   
                 1998 
                 0.00075 
               
               
                   
                 1999 
                 0.00082 
               
               
                   
                 2000 
                 0.015 
               
               
                   
                 2001 
                 0.00048 
               
               
                   
                 2002 
                 0.0030 
               
               
                   
                 2003 
                 0.0086 
               
               
                   
                 2004 
                 0.00033 
               
               
                   
                 2005 
                 0.00064 
               
               
                   
                 2006 
                 0.00062 
               
               
                   
                 2007 
                 0.23 
               
               
                   
                 2008 
                 0.14 
               
               
                   
                 2009 
                 0.082 
               
               
                   
                 2010 
                 0.22 
               
               
                   
                 2011 
                 0.017 
               
               
                   
                 2012 
                 0.20 
               
               
                   
                 2013 
                 0.15 
               
               
                   
                 2014 
                 0.34 
               
               
                   
                 2015 
                 0.26 
               
               
                   
                 2016 
                 0.27 
               
               
                   
                 2017 
                 0.35 
               
               
                   
                 2018 
                 0.32 
               
               
                   
                 2019 
                 0.11 
               
               
                   
                 2020 
                 0.27 
               
               
                   
                 2021 
                 0.0028 
               
               
                   
                 2022 
                 0.0038 
               
               
                   
                 2023 
                 0.0017 
               
               
                   
                 2024 
                 0.0043 
               
               
                   
                 2025 
                 0.0014 
               
               
                   
                 2026 
                 0.0013 
               
               
                   
                 2027 
                 0.11 
               
               
                   
                 2028 
                 0.011 
               
               
                   
                 2029 
                 0.00083 
               
               
                   
                 2030 
                 0.0023 
               
               
                   
                 2031 
                 0.00082 
               
               
                   
                 2032 
                 0.0012 
               
               
                   
                 2033 
                 0.00065 
               
               
                   
                 2034 
                 0.0020 
               
               
                   
                 2035 
                 0.024 
               
               
                   
                 2036 
                 0.0011 
               
               
                   
                 2037 
                 0.00058 
               
               
                   
                 2038 
                 0.0083 
               
               
                   
                 2039 
                 0.018 
               
               
                   
                 2040 
                 0.15 
               
               
                   
                 2041 
                 0.11 
               
               
                   
                 2042 
                 0.070 
               
               
                   
                 2043 
                 0.012 
               
               
                   
                 2044 
                 0.0079 
               
               
                   
                 2045 
                 0.015 
               
               
                   
                 2046 
                 0.0037 
               
               
                   
                 2047 
                 0.0057 
               
               
                   
                 2048 
                 0.0035 
               
               
                   
                 2049 
                 0.0040 
               
               
                   
                 2050 
                 0.051 
               
               
                   
                 2051 
                 0.0025 
               
               
                   
                 2052 
                 0.0049 
               
               
                   
                 2053 
                 0.010 
               
               
                   
                 2054 
                 0.0041 
               
               
                   
                 2055 
                 0.027 
               
               
                   
                 2056 
                 0.013 
               
               
                   
                 2057 
                 0.0011 
               
               
                   
                 2058 
                 0.38 
               
               
                   
                 2059 
                 0.00096 
               
               
                   
                 2060 
                 0.11 
               
               
                   
                 2061 
                 0.021 
               
               
                   
                 2062 
                 0.0069 
               
               
                   
                 2063 
                 0.0088 
               
               
                   
                 2064 
                 0.012 
               
               
                   
                 2065 
                 0.016 
               
               
                   
                 2066 
                 0.063 
               
               
                   
                 2067 
                 0.00084 
               
               
                   
                 2068 
                 0.0017 
               
               
                   
                 2069 
                 0.078 
               
               
                   
                 2070 
                 0.018 
               
               
                   
                 2071 
                 0.0092 
               
               
                   
                 2072 
                 0.00042 
               
               
                   
                 2073 
                 0.012 
               
               
                   
                 2074 
                 0.0027 
               
               
                   
                 2075 
                 0.0011 
               
               
                   
                 2076 
                 0.0025 
               
               
                   
                 2077 
                 0.047 
               
               
                   
                 2078 
                 0.011 
               
               
                   
                 2079 
                 0.017 
               
               
                   
                 2080 
                 0.00033 
               
               
                   
                 2081 
                 0.0020 
               
               
                   
                 2082 
                 0.041 
               
               
                   
                 2083 
                 0.052 
               
               
                   
                 2084 
                 0.13 
               
               
                   
                 2085 
                 0.0029 
               
               
                   
                 2086 
                 0.10 
               
               
                   
                 2087 
                 0.13 
               
               
                   
                 2088 
                 0.030 
               
               
                   
                 2089 
                 0.30 
               
               
                   
                 2090 
                 0.38 
               
               
                   
                 2091 
                 0.27 
               
               
                   
                 2092 
                 0.35 
               
               
                   
                 2093 
                 0.037 
               
               
                   
                 2094 
                 0.20 
               
               
                   
                 2095 
                 0.24 
               
               
                   
                 2096 
                 0.019 
               
               
                   
                 2097 
                 0.00057 
               
               
                   
                 2098 
                 0.0080 
               
               
                   
                 2099 
                 0.025 
               
               
                   
                 2100 
                 0.015 
               
               
                   
                 2101 
                 0.053 
               
               
                   
                 2102 
                 0.00092 
               
               
                   
                 2103 
                 0.0083 
               
               
                   
                 2104 
                 0.010 
               
               
                   
                 2105 
                 0.0026 
               
               
                   
                 2106 
                 0.0020 
               
               
                   
                 2107 
                 0.0048 
               
               
                   
                 2108 
                 0.0079 
               
               
                   
                 2109 
                 0.0018 
               
               
                   
                 2110 
                 0.0098 
               
               
                   
                 2111 
                 0.0082 
               
               
                   
                 2112 
                 0.011 
               
               
                   
                 2113 
                 0.00047 
               
               
                   
                 2114 
                 0.11 
               
               
                   
                 2115 
                 0.0011 
               
               
                   
                 2116 
                 0.11 
               
               
                   
                 2117 
                 0.00041 
               
               
                   
                 2118 
                 0.0032 
               
               
                   
                 2119 
                 0.00039 
               
               
                   
                 2120 
                 0.0010 
               
               
                   
                 2121 
                 0.00056 
               
               
                   
                 2122 
                 0.00046 
               
               
                   
                 2123 
                 0.0015 
               
               
                   
                 2124 
                 0.00091 
               
               
                   
                 2125 
                 0.016 
               
               
                   
                 2126 
                 0.037 
               
               
                   
                 2127 
                 0.0045 
               
               
                   
                 2128 
                 0.015 
               
               
                   
                 2129 
                 0.046 
               
               
                   
                 2130 
                 0.010 
               
               
                   
                 2131 
                 0.0098 
               
               
                   
                 2132 
                 0.091 
               
               
                   
                 2133 
                 0.012 
               
               
                   
                 2134 
                 0.0098 
               
               
                   
                 2135 
                 0.088 
               
               
                   
                 2136 
                 0.039 
               
               
                   
                 2137 
                 0.069 
               
               
                   
                 2138 
                 0.0086 
               
               
                   
                 2139 
                 0.023 
               
               
                   
                 2140 
                 0.032 
               
               
                   
                 2141 
                 0.072 
               
               
                   
                 2142 
                 0.044 
               
               
                   
                 2143 
                 0.041 
               
               
                   
                 2144 
                 0.0069 
               
               
                   
                 2145 
                 0.022 
               
               
                   
                 2146 
                 0.0051 
               
               
                   
                 2147 
                 0.0080 
               
               
                   
                 2148 
                 0.063 
               
               
                   
                 2149 
                 0.0040 
               
               
                   
                 2150 
                 0.0057 
               
               
                   
                 2151 
                 0.0025 
               
               
                   
                 2152 
                 0.071 
               
               
                   
                 2153 
                 0.0069 
               
               
                   
                 2154 
                 0.033 
               
               
                   
                 2155 
                 0.028 
               
               
                   
                 2156 
                 0.0045 
               
               
                   
                 2157 
                 0.0069 
               
               
                   
                 2158 
                 0.089 
               
               
                   
                 2159 
                 0.0035 
               
               
                   
                 2160 
                 0.0038 
               
               
                   
                 2161 
                 0.48 
               
               
                   
                 2162 
                 0.20 
               
               
                   
                 2163 
                 0.073 
               
               
                   
                 2164 
                 0.30 
               
               
                   
                 2165 
                 0 22 
               
               
                   
                 2166 
                 0.33 
               
               
                   
                 2167 
                 0.38 
               
               
                   
                 2168 
                 0.0013 
               
               
                   
                 2169 
                 0.0061 
               
               
                   
                 2170 
                 0.069 
               
               
                   
                 2171 
                 0.12 
               
               
                   
                 2172 
                 0.014 
               
               
                   
                 2173 
                 0.0060 
               
               
                   
                 2174 
                 0.87 
               
               
                   
                 2175 
                 0 18 
               
               
                   
                 2176 
                 0 12 
               
               
                   
                 2177 
                 0 25 
               
               
                   
                 2178 
                 0 16 
               
               
                   
                 2179 
                 0.54 
               
               
                   
                 2180 
                 0.00093 
               
               
                   
                 2181 
                 0.0055 
               
               
                   
                 2182 
                 0.0036 
               
               
                   
                 2183 
                 0.0019 
               
               
                   
                 2184 
                 0.0079 
               
               
                   
                 2185 
                 0.0024 
               
               
                   
                 2186 
                 0.0075 
               
               
                   
                   
               
            
           
         
       
     
     Measurement of AsPC-1 Cell Growth Inhibition AsPC-1 CG 
     Test compounds were serially diluted with dimethyl sulfoxide, and 200 nL was then dispensed to a U-bottom 96-well plate using Labcyte Echo. Human pancreatic cancer cell line AsPC-1 was suspended in RPMI-1640 medium supplemented with 15% fetal bovine serum to prepare a cell suspension at 1000 cells/100 μL. The cell suspension was dispensed to a plate containing a test compound at 100 μL per well and incubated at 37° C. in a 5% carbon dioxide gas incubator. 96 hours later, 80 μL of CellTiter-Glo (Promega) was added to each well and fluorescence was measured. The cell growth inhibition (CGI) of the test compound was calculated as 50% growth inhibitory concentration (IC50 value) from the growth inhibition rate when the test compound was added relative to the test compound-free control. IC50 values (μM) of the test compounds were classified in that range and the results are shown below. 
     Cyclic peptide compounds of Compound Nos. 5, 9, 16, 20, 27, 33, 40, 47, 54, 55, 66, 120, 132, 134, 144, 150, 176, 209, 245, 253, 270, 276, 279, 289, 301, 302, 303, 308, 316, 334, 342, 343, 344, 362, 363, 370, 371, 374, 378, 381, 390, 391, 400, 404, 415, 422, 432, 466, 481, 506, 509, 515, 529, 545, 547, 555, 567, 571, 574, 587, 589, 594, 626, 630, 640, 668, 678, 690, 693, 695, 713, 717, 721, 731, 734, 775, 799, 806, 816, 835, 836, 840, 863, 866, 871, 882, 896, 907, 926, 938, 965, 973, 974, 981, 987, 999, 1017, 1042, 1059, 1070, 1080, 1091, 1099, 1116, 1117, 1120, 1132, 1139, 1141, 1143, 1144, 1148, 1149, 1151, 1152, 1158, 1160, 1162, 1163, 1165, 1166, 1170, 1173, 1175, 1179, 1182, 1183, 1190, 1192, 1194, 1196, 1199, 1201, 1204, 1205, 1206, 1208, 1209, 1210, 1215, 1217, 1220, 1224, 1231, 1232, 1234, 1237, 1241, 1242, 1244, 1245, 1248, 1250, 1259, 1260, 1261, 1264, 1267, 1269, 1270, 1271, 1272, 1281, 1282, 1283, 1285, 1289, 1290, 1293, 1295, 1296, 1297, 1301, 1303, 1306, 1308, 1310, 1311, 1312, 1317, 1319, 1320, 1322, 1324, 1325, 1330, 1333, 1335, 1336, 1337, 1339, 1341, 1342, 1343, 1346, 1348, 1351, 1356, 1357, 1360, 1362, 1363, 1364, 1365, 1366, 1367, 1368, 1369, 1370, 1371, 1645, 1649, 1659, 1661, 1662, 1750, 1756, 1772, 1777, 1779, 1787, 1792, 1793, 1809, 1818, 1836, 1842, 1843, 1858, 1865, 1875, 1886, 1894, 1898, 1962, 1977, 1979, 1985, 1990, 2001, and 2080 showed an IC50 value which is 0.02 (μM) or lower. 
     Cyclic peptide compounds of Compound Nos. 44, 48, 49, 56, 73, 79, 89, 127, 128, 155, 173, 182, 201, 236, 243, 263, 272, 311, 313, 339, 340, 366, 386, 388, 403, 410, 441, 469, 531, 558, 563, 622, 647, 684, 694, 726, 768, 774, 776, 778, 790, 807, 814, 818, 827, 868, 885, 890, 900, 918, 921, 958, 959, 977, 1000, 1001, 1002, 1008, 1029, 1030, 1046, 1060, 1062, 1073, 1093, 1098, 1137, 1142, 1146, 1154, 1159, 1164, 1171, 1193, 1197, 1198, 1223, 1228, 1236, 1251, 1253, 1254, 1275, 1278, 1287, 1292, 1299, 1326, 1340, 1355, 1658, 1675, 1679, 1685, 1694, 1700, 1701, 1722, 1726, 1727, 1729, 1757, 1761, 1762, 1790, 1821, 1840, 1850, 1851, 1852, 1870, 1871, 1872, 1884, 1890, 1904, 1905, 1907, 1925, 1930, 1936, 1938, 1948, 1950, 1958, 1972, 1978, 1983, 1984, 1996, 2004, 2067, 2072, and 2119 showed an IC50 value which is higher than 0.02 (μM) and is 0.05 (μM) or lower. 
     Cyclic peptide compounds of Compound Nos. 11, 68, 88, 126, 137, 160, 161, 163, 239, 246, 274, 292, 326, 327, 353, 385, 408, 409, 411, 420, 425, 434, 437, 438, 453, 486, 518, 532, 535, 543, 551, 562, 608, 616, 650, 652, 662, 674, 677, 683, 699, 701, 708, 712, 735, 783, 820, 825, 837, 845, 859, 881, 904, 909, 912, 948, 1023, 1037, 1047, 1112, 1150, 1176, 1178, 1180, 1189, 1233, 1309, 1321, 1331, 1338, 1359, 1374, 1463, 1475, 1496, 1512, 1524, 1537, 1549, 1550, 1551, 1563, 1570, 1571, 1572, 1590, 1597, 1604, 1610, 1617, 1620, 1621, 1629, 1634, 1637, 1653, 1654, 1668, 1671, 1680, 1689, 1696, 1714, 1717, 1720, 1728, 1735, 1740, 1746, 1748, 1770, 1784, 1785, 1786, 1795, 1798, 1800, 1801, 1804, 1805, 1807, 1812, 1824, 1835, 1861, 1869, 1879, 1881, 1892, 1901, 1906, 1908, 1911, 1915, 1923, 1932, 1933, 1941, 1947, 1963, 1965, 1966, 1968, 1969, 1975, 1988, 1993, 1994, 2005, 2006, 2057, 2063, 2074, 2076, 2118, 2121, and 2122 showed an IC50 value which is higher than 0.05 (μM) and is 0.1 (μM) or lower. 
     Cyclic peptide compounds of Compound Nos. 2, 15, 23, 30, 35, 36, 37, 39, 52, 58, 60, 64, 72, 78, 80, 81, 86, 90, 94, 100, 106, 108, 110, 119, 121, 122, 131, 136, 140, 147, 157, 164, 168, 207, 211, 212, 216, 220, 221, 223, 225, 229, 238, 249, 250, 256, 264, 273, 285, 287, 288, 294, 300, 309, 319, 321, 328, 337, 341, 348, 354, 356, 360, 364, 367, 384, 387, 393, 395, 397, 399, 416, 428, 439, 445, 446, 449, 455, 456, 461, 470, 476, 478, 480, 488, 491, 496, 497, 520, 523, 526, 544, 548, 552, 559, 561, 568, 572, 575, 580, 599, 600, 606, 618, 620, 629, 631, 644, 663, 667, 672, 676, 680, 689, 700, 714, 732, 740, 747, 749, 755, 756, 757, 762, 771, 787, 789, 798, 804, 809, 811, 815, 824, 838, 849, 853, 854, 872, 873, 877, 880, 888, 893, 901, 910, 911, 916, 920, 929, 930, 943, 944, 957, 960, 961, 968, 971, 980, 983, 985, 988, 995, 997, 1005, 1012, 1014, 1018, 1019, 1022, 1026, 1035, 1036, 1038, 1040, 1051, 1055, 1057, 1064, 1066, 1069, 1071, 1072, 1109, 1114, 1115, 1124, 1128, 1130, 1140, 1145, 1153, 1167, 1172, 1181, 1203, 1207, 1213, 1218, 1227, 1235, 1252, 1255, 1262, 1266, 1273, 1284, 1291, 1302, 1315, 1323, 1329, 1332, 1334, 1347, 1353, 1376, 1439, 1454, 1457, 1458, 1462, 1466, 1471, 1477, 1481, 1482, 1485, 1486, 1497, 1498, 1499, 1500, 1501, 1504, 1508, 1514, 1523, 1544, 1555, 1557, 1561, 1564, 1565, 1567, 1569, 1576, 1579, 1583, 1584, 1588, 1589, 1594, 1596, 1598, 1599, 1601, 1602, 1605, 1607, 1608, 1609, 1611, 1615, 1616, 1625, 1626, 1630, 1631, 1632, 1633, 1636, 1638, 1639, 1640, 1641, 1643, 1646, 1648, 1650, 1652, 1656, 1657, 1663, 1669, 1670, 1672, 1673, 1682, 1684, 1686, 1693, 1699, 1704, 1705, 1709, 1711, 1712, 1713, 1716, 1731, 1737, 1738, 1739, 1744, 1749, 1751, 1758, 1763, 1764, 1766, 1767, 1773, 1774, 1789, 1791, 1796, 1797, 1803, 1817, 1825, 1828, 1829, 1830, 1832, 1833, 1838, 1845, 1846, 1847, 1854, 1859, 1860, 1863, 1866, 1867, 1877, 1896, 1900, 1913, 1916, 1921, 1924, 1926, 1928, 1929, 1931, 1934, 1939, 1940, 1949, 1954, 1955, 1956, 1957, 1971, 1976, 1980, 1998, 1999, 2031, 2059, 2064, 2065, 2077, 2078, 2084, 2085, 2097, 2102, 2117, 2120, 2123, 2124, 2131, 2138, 2139, and 2168 showed an IC50 value which is higher than 0.1 (μM) and is 0.5 (μM) or lower. 
     Cyclic peptide compounds of Compound Nos. 1, 4, 6, 7, 10, 12, 13, 14, 17, 22, 24, 32, 43, 45, 57, 59, 61, 63, 67, 69, 71, 75, 76, 83, 87, 91, 92, 93, 95, 97, 102, 103, 109, 111, 114, 115, 116, 117, 118, 123, 124, 125, 133, 135, 139, 141, 142, 143, 145, 146, 148, 149, 151, 156, 158, 159, 162, 165, 166, 169, 171, 172, 174, 175, 177, 178, 179, 180, 183, 185, 186, 187, 188, 191, 192, 194, 195, 196, 197, 200, 202, 204, 205, 208, 210, 213, 217, 218, 226, 228, 230, 231, 232, 234, 235, 237, 247, 248, 251, 254, 255, 257, 259, 262, 265, 266, 268, 275, 277, 278, 280, 281, 283, 284, 295, 297, 298, 304, 305, 307, 312, 314, 317, 318, 320, 325, 329, 330, 332, 335, 336, 346, 347, 352, 357, 358, 368, 376, 379, 380, 382, 389, 392, 394, 402, 405, 407, 417, 418, 419, 421, 423, 426, 427, 433, 440, 442, 443, 444, 447, 450, 451, 454, 457, 458, 459, 460, 463, 468, 471, 477, 483, 484, 485, 487, 489, 492, 495, 498, 500, 501, 504, 507, 508, 511, 514, 516, 519, 522, 524, 527, 528, 533, 534, 538, 540, 542, 549, 553, 554, 556, 557, 564, 565, 569, 570, 577, 581, 584, 585, 586, 590, 591, 592, 593, 596, 597, 598, 603, 604, 605, 614, 619, 623, 627, 635, 636, 638, 641, 643, 645, 648, 653, 656, 661, 664, 665, 666, 670, 681, 682, 687, 688, 691, 692, 696, 697, 703, 705, 706, 707, 709, 710, 711, 715, 716, 718, 720, 722, 723, 725, 727, 728, 729, 730, 736, 741, 742, 744, 745, 753, 754, 760, 765, 766, 767, 769, 770, 772, 781, 782, 784, 786, 788, 792, 794, 796, 797, 800, 801, 803, 805, 810, 812, 813, 819, 821, 822, 823, 829, 841, 842, 844, 848, 850, 851, 855, 856, 857, 858, 861, 862, 864, 867, 874, 875, 876, 879, 883, 887, 892, 894, 895, 897, 903, 905, 906, 908, 913, 914, 915, 917, 933, 934, 935, 936, 939, 940, 941, 942, 945, 946, 950, 954, 955, 956, 963, 964, 967, 969, 970, 975, 979, 982, 986, 991, 993, 994, 998, 1004, 1007, 1009, 1010, 1011, 1015, 1016, 1020, 1021, 1024, 1025, 1027, 1033, 1034, 1041, 1043, 1044, 1045, 1050, 1053, 1054, 1056, 1058, 1061, 1063, 1068, 1076, 1077, 1079, 1081, 1083, 1084, 1087, 1089, 1094, 1095, 1096, 1100, 1101, 1103, 1105, 1106, 1110, 1111, 1121, 1123, 1125, 1129, 1133, 1134, 1135, 1138, 1157, 1169, 1174, 1177, 1185, 1186, 1187, 1188, 1191, 1195, 1200, 1202, 1211, 1214, 1216, 1219, 1221, 1222, 1225, 1226, 1229, 1230, 1238, 1239, 1243, 1246, 1247, 1249, 1256, 1257, 1258, 1263, 1268, 1274, 1276, 1277, 1279, 1286, 1288, 1294, 1298, 1300, 1304, 1305, 1307, 1313, 1314, 1316, 1318, 1327, 1328, 1345, 1350, 1354, 1358, 1361, 1372, 1377, 1380, 1386, 1387, 1388, 1392, 1396, 1397, 1398, 1403, 1404, 1411, 1414, 1415, 1417, 1419, 1421, 1422, 1424, 1425, 1426, 1428, 1429, 1432, 1433, 1435, 1436, 1438, 1440, 1441, 1443, 1444, 1448, 1449, 1451, 1452, 1453, 1455, 1456, 1459, 1460, 1461, 1465, 1467, 1469, 1472, 1474, 1476, 1478, 1480, 1483, 1484, 1489, 1490, 1491, 1493, 1495, 1502, 1503, 1506, 1507, 1509, 1511, 1515, 1517, 1518, 1519, 1520, 1526, 1527, 1528, 1529, 1532, 1533, 1534, 1535, 1536, 1539, 1541, 1545, 1546, 1547, 1553, 1556, 1559, 1562, 1566, 1573, 1574, 1575, 1578, 1580, 1582, 1585, 1587, 1591, 1595, 1606, 1613, 1614, 1623, 1627, 1635, 1644, 1647, 1651, 1660, 1664, 1665, 1666, 1667, 1674, 1676, 1677, 1678, 1681, 1687, 1688, 1690, 1692, 1695, 1697, 1698, 1702, 1703, 1706, 1707, 1708, 1715, 1718, 1719, 1721, 1723, 1724, 1725, 1730, 1732, 1733, 1736, 1741, 1742, 1743, 1745, 1747, 1752, 1753, 1754, 1755, 1759, 1760, 1768, 1769, 1771, 1775, 1776, 1778, 1780, 1782, 1788, 1799, 1802, 1806, 1808, 1810, 1811, 1813, 1815, 1816, 1819, 1820, 1822, 1823, 1826, 1827, 1831, 1834, 1837, 1841, 1844, 1848, 1849, 1853, 1855, 1856, 1857, 1862, 1864, 1880, 1897, 1917, 1937, 1946, 1973, 1982, 2030, 2035, 2058, 2060, 2061, 2062, 2066, 2068, 2069, 2070, 2071, 2073, 2075, 2079, 2081, 2082, 2083, 2113, 2115, 2116, 2125, 2127, 2128, 2129, 2130, 2132, 2135, 2136, 2137, 2140, 2141, 2142, 2143, 2144, 2145, 2146, 2147, 2149, 2150, 2151, 2169, 2172, 2173, 2174, 2175, 2176, 2177, 2178, and 2179 showed an IC50 value which is higher than 0.5 (μM). 
       
     
       
         
           
               
             
               
                 Lengthy table referenced here 
               
             
            
               
                 US20230151060A1-20230518-T00001 
               
               
                 Please refer to the end of the specification for access instructions. 
               
            
           
         
       
     
     INDUSTRIAL APPLICABILITY 
     The present invention provides cyclic peptide compounds having a Kras inhibitory effect. The present invention also provides amino acids useful as raw materials for the cyclic peptide compounds. 
       
     
       
         
           
               
             
               
                 LENGTHY TABLES 
               
             
            
               
                 The patent application contains a lengthy table section. A copy of the table is available in electronic form from the USPTO web site (https://seqdata.uspto.gov/?pageRequest=docDetail&amp;DocID=US20230151060A1). An electronic copy of the table will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).