Patent Publication Number: US-2021177429-A1

Title: Aneurysm method and system

Description:
CROSS REFERENCE TO RELATED APPLICATIONS 
     This application is a continuation of U.S. non-provisional patent application Ser. No. 16/997,543, which is a continuation of U.S. non-provisional patent application Ser. No. 15/903,860, which claims priority to U.S. provisional patent application No. 62/462,685 entitled “ANEURYSM DEVICE AND DELIVERY SYSTEM” and filed Feb. 23, 2017, the contents of each of which are incorporated herein by reference as if set forth verbatim. 
    
    
     FIELD 
     This disclosure relates to medical instruments, and more particularly, delivery systems for a device for aneurysm therapy. 
     BACKGROUND 
     Aneurysms can be complicated and difficult to treat. For example, treatment access may be limited or unavailable when an aneurysm is located proximate critical tissues. Such factors are of particular concern with cranial aneurysms due to the presence of brain tissue surrounding cranial vessels. 
     Prior solutions have included endovascular treatment access whereby an internal volume of the aneurysm sac is removed or excluded from arterial blood pressure and flow. 
     Alternative to endovascular or other surgical approaches can include occlusion devices. Such devices have typically incorporated multiple embolic coils that are delivered to the vasculature using microcatheter delivery systems. For example, when treating cranial aneurysms, a delivery catheter with embolic coils is typically first inserted into non-cranial vasculature through a femoral artery in the hip or groin area. Thereafter, the catheter is guided to a location of interest within the cranium. The sac of the aneurysm can then be filled with the embolic material to create a thrombotic mass that protects the arterial walls from blood flow and related pressure. One particular type of occlusive approach endeavors to deliver and treat the entrance or “neck” of the aneurysm as opposed to the volume of the aneurysm. In such “neck” approaches, by minimizing blood flow across the neck, then a venous stasis in the aneurysm may be achieved. In turn, a thrombotic mass may naturally form without having to deliver embolic materials, as previously described. This is preferable to masses formed from embolic material since a natural mass can improve healing by reducing possible distention from arterial walls and permits reintegration into the original parent vessel shape along the neck plane of the aneurysm. It is understood that the neck plane is an imaginary surface where the inner most layer of the parent wall would be but for the aneurysm. However, neck-occlusive approaches are not without drawbacks. It is typical for neck-occlusive approaches to fail to impede flow into blood vessels while also blocking the aneurysm neck in the parent vessel. This can unintentionally lead to severe damage if the openings of the vessels are blocked. Furthermore, embolic coils do not always effectively treat aneurysms as re-canalization of the aneurysm and/or coil compaction can occur over time. 
     Several embodiments of an occlusion device are described in U.S. Pat. No. 8,998,947. However, this approach relies upon the use of embolic coils or mimics the coil approach to obtain a safe packing density and therefore unnecessarily risks rupture of the aneurysm. Furthermore, this approach fails to teach a delivery system whereby an occlusion device can be re-positioned after initial positioning of its aneurysm occlusion structure to ensure patient safety associated with precise positioning. 
     It is therefore desirable to have a device which easily, accurately, and safely occludes a neck of an aneurysm or other arterio-venous malformation in a parent vessel without blocking flow into perforator vessels communicating with the parent vessel. 
     SUMMARY 
     In some aspects, the present disclosure relates to a medical device for treating an aneurysm. The device can include a self-expanding braided tubular implant (hereinafter “braid”) with a lumen that has a distal implant end and a proximal implant end. The distal implant end can be opposite the proximal implant end. Distal translation of the braid from within a tubular delivery member can cause the distal implant end to invert and fold into itself thereby forming an occlusive sack for occluding an aneurysm. 
     In certain embodiments, the tubular delivery member can be disposed about the implant and have a distal end that is releasably connected to the distal implant end of the braid. The braid can have a longitudinal axis between the distal implant end and the proximal implant end. The braid can be invertible about the longitudinal axis by distally translating the braid about the axis. 
     In certain embodiments, the lumen of the braid can include a pre-fabricated break that is disposed between the distal and implant ends. The break can be formed from localized heat treatment zone that is kink-preventative and configured to induce gradual folding and/or inversion of the braid. The break can be disposed between the distal and implant ends. The break can be configured for the occlusive sack to form when the distal implant end is translated toward or contacts a dome of the aneurysm. In some embodiments, one or more regions or areas of the distal end of the distal implant end are substantially atraumatic or rounded and configured to minimize kinking of the braid during inversion. In certain embodiments, continuing to translate the braid upon formation of the occlusive sack can lead to formation of a second sack within the occlusive sack. Additional sacks can be formed within the first and second sacks as needed or required (e.g. to achieve a desired packing density or to further support the first and second sacks). It is understood that each sack can be formed from a respective portion of the braid inverting and folding into itself. 
     In certain embodiments, the proximal implant end is operable to mechanically attach to a delivery system. The delivery system can include a catheter and a pushing mechanism disposed in the catheter and/or including a hypotube, the pushing mechanism operable to translate the braid toward the aneurysm. In certain embodiments, the occlusive sack can be substantially spherical, ellipsoidal, or otherwise conformable to an asymmetric aneurysm, for example, an aneurysm with multiple sacs, irregular dome or walls. The proximal implant end can also be less pliable and/or can have less material strength than the distal implant end. An outer surface of the braid can also include a plurality of interstices (e.g. a mesh surface). 
     The invertibility, pliability, and/or porosity of the braid can be selectively designed for treatment of an aneurysm having a particular shape, by varying properties of the interstices among different portions of the braid. 
     In other embodiments, a method of delivering an occlusion device to an aneurysm in a blood vessel in a patient is disclosed. The method can include positioning an occlusion device within a delivery tube (e.g. a tube that can be pushed or caused to translate the occlusion device), the occlusion device comprising any self-expanding braid of this disclosure; distally sliding the braid towards the aneurysm from within the delivery tube; expanding a distal implant end of the braid from a collapsed condition to a deployed condition; and inverting the distal implant end of the braid to form a sack for occluding the aneurysm. 
     In certain embodiments, the distal implant end of the braid begins expanding immediately as the braid exits a distal end of the delivery tube. In certain embodiments, when the sack is formed, it can include a predetermined packing density or density range. In certain embodiments, the method can include positioning a microcatheter within the vasculature and then positioning the occlusion device assembled with the delivery tube inside the microcatheter; and delivering the occlusion device and the delivery tube assembled with the microcatheter to the aneurysm. In certain embodiments, the method can also include: imaging the sack with respect to the aneurysm; determining whether the aneurysm is occluded by the sack; and distally or proximally sliding the braid to adjust the sack and to occlude the aneurysm. 
     In certain embodiments, imaging the sack with respect to the aneurysm includes determining whether a necessary packing setting for the sack to occlude the aneurysm and moving the braid (e.g. by distally or proximally sliding the braid) to adjust the sack. 
     In other embodiments, a method of delivering an occlusion device to an aneurysm in a blood vessel in a patient is disclosed. The method can include: positioning the occlusion device within a delivery tube, the occlusion device comprising a self-expanding braid; distally sliding a braid toward the aneurysm; expanding (e.g. radially expanding) a distal implant end of the braid from a collapsed condition to a deployed condition as the braid approaches a dome of the aneurysm; and inverting the distal implant end of the braid to form an occlusive sack that packs the aneurysm to a predetermined packing density and occludes the aneurysm. 
     In certain embodiments, the braid includes a first break that is defined by a size of the sack for occluding the aneurysm. The braid can also include a second break proximal of the first break. In this respect, the method can also include distally sliding the braid toward the aneurysm after formation of the first sack; and inverting the braid at the second break to form a second sack internal to the first sack. 
     In certain embodiments, the method can also include: distally sliding the braid toward the aneurysm after formation of the first sack; and inverting the braid to form a second sack internal to the first sack. 
     In certain embodiments, the method can also include: continuing to distally slide the braid toward the aneurysm after formation of the first sack thereby packing the sack with one or more unexpanded portions of the braid. 
     In certain embodiments, the method can also include: determining a position of the sack relative to the aneurysm and if the position fails to fit or conform to the sack, then the braid may be proximally translated thereby causing the sack to collapse back into the braid; and withdrawing the braid from the aneurysm. 
     In other embodiments, this disclosure relates to a delivery system for an occlusive device for treating an aneurysm. In some embodiments, the delivery system can include a delivery tube that includes a distal end and a proximal end. The delivery tube can be slidably disposed within a microcatheter. A pushing mechanism can be slidably disposed within the delivery tube. The occlusive device can be slidably disposed within the delivery tube and mechanically attached to the pushing mechanism. The occlusive device can include a braid having a lumen with a distal implant end opposite a proximal implant end. The pushing mechanism can be operable to distally translate the occlusive device to a deployed condition within the aneurysm, wherein distally translating the braid to the deployed condition causes the distal implant end to invert and fold into itself thereby forming an occlusive sack for the aneurysm. 
     In certain embodiments, the proximal implant end of the braid may be capable of mechanical attachment, detachable or otherwise, to the distal end of the pushing mechanism. 
     In other embodiments, at least a portion of the braid defines a plurality of interstices with openings for occlusion of the aneurysm. In other embodiments, the proximal implant end of the braid can be attached to and foldable over an inner portion of the pushing mechanism. 
     In other embodiments, the braid can be attached to and foldable over an inner portion of the pushing mechanism. The braid may also be fillable as the braid is folded. In certain embodiments, the braid can be invertible as the braid distally slides and exits the delivery tube. The sack may be a collapsible cage-like vaso-occlusive structure. 
     In other embodiments, the distal end of the delivery member can include opposed gripping arms (e.g., upper and lower). One or both gripping arms can be pivotable toward the other gripping arm to release the braid from the delivery tube when the braid forms a sack about the. In other embodiments, the pushing mechanism can also include an inner passage through which at least one embolic coil is insertable into the braid when the braid forms a sack within the aneurysm. 
     In other embodiments, the pushing mechanism can include radiopaque material (e.g. the distal end, the proximal end, etc.). 
     In other embodiments, a method is disclosed for delivering an occlusion device to an aneurysm in a blood vessel in a patient. The method includes: positioning a delivery system of the occlusion device within a microcatheter in the vasculature, the delivery system including a delivery tube having a distal end and a proximal end. The delivery system may also include a pushing mechanism that is slidably disposed within the delivery tube, the pushing mechanism comprising a distal end and a proximal end. The method may include slidably positioning a self-expanding braid of the occlusion device within the delivery tube, the braid comprising a distal end and a proximal end; detachably attaching the proximal end of the braid to the distal end of the pushing mechanism; selectively inserting the microcatheter with the delivery system and the occlusion device into vasculature of the patient to reach the aneurysm; distally sliding the braid, by the pushing mechanism, in the delivery tube toward the aneurysm thereby causing the braid to radially expand and move from a collapsed condition within the delivery tube to a deployed condition within the aneurysm as the distal end of the braid is moved outside and away from the distal end of the delivery tube; and releasing the occlusion device and withdrawing the microcatheter and the delivery system from the patient. 
     In other embodiments, the method can also include: forming, by the braid, a sack within the aneurysm by distally sliding the braid to the deployed condition; distally sliding the pushing mechanism to the distal end of delivery tube until the braid folds; and folding the braid thereby filling the sack and securing the occlusion device within the aneurysm to occlude flow into the aneurysm. 
     In other embodiments, the method can also include: forming the sack within the aneurysm by inverting the braid as the braid distally slides and exits the delivery tube and/or bulges against a wall of the aneurysm. 
     In other embodiments, the method can also include: deflecting the pushing mechanism as the braid is inverted and reaches a dome of the aneurysm; filling the sack as the braid is inverted; and/or continuing to distally translate, by the pushing mechanism, the braid into the aneurysm until the proximal end of the braid reaches the distal end tip of the pushing mechanism. 
     In other embodiments, the method can also include: attaching the proximal end of the braid to an inner portion of the pushing mechanism; and/or filling the sack by folding the braid until the braid is at least level with a neck of the aneurysm. 
     In other embodiments, the method can also include: forming, by the braid, a sack within the aneurysm by distally sliding the braid to the deployed condition; forming a gripping mechanism for detaching the sack from the delivery system, the gripping mechanism being formed by a pair of opposed gripping arms formed at a distal end of the delivery tube, one or both gripping arms being pivotable toward the other gripping arm; and/or detaching, by the grabbing mechanism of the delivery system, the sack from the delivery system by pivoting one or both arms away from the other. 
     In other embodiments, the method can also include: inserting at least one embolic coil through an inner passage of the pushing mechanism and into the sack to adjust the packing density. 
     In other embodiments, the method can include forming, by inverting the braid, a first occlusive sack within the aneurysm by distally sliding the braid from the delivery tube toward the aneurysm; distally sliding the braid toward the aneurysm after formation of the first sack; and inverting the braid to form a second sack within the first sack. Forming the first and/or second sack can cause flow into the aneurysm to be deflected, diverted, and/or slowed. 
     In other embodiments, the method can include forming, by inverting the braid, a first occlusive sack within the aneurysm by distally sliding the braid from the delivery tube toward the aneurysm; distally sliding the braid toward the aneurysm after formation of the first sack; inverting the braid to form a second sack within the first sack; distally sliding the braid toward the aneurysm after formation of the second sack; and inverting the braid to form a third sack within the first and second sacks. Forming the first, second and/or third sack can cause flow into the aneurysm to be deflected, diverted, and/or slowed. It is contemplated that only one sack could be used or more than three sacks could be formed and used for purposes of deflecting, diverting, and/or slowing flow into the aneurysm. 
     Other aspects and features of the present disclosure will become apparent to those of ordinary skill in the art, upon reviewing the following detailed description in conjunction with the accompanying figures. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       Reference will now be made to the accompanying drawings, which are not necessarily drawn to scale. 
         FIG. 1  depicts an example occlusion device of this disclosure deployed into an aneurysm. 
         FIG. 2  is a schematic side view of an exemplary delivery system with an occlusion device held in a collapsed condition within a microcatheter. 
         FIG. 3  is an enlarged schematic side view of the delivery system of  FIG. 2  along section A-A; 
         FIG. 4  is a flow diagram for a method of delivering an occlusion device to the vasculature using the herein disclosed delivery system; 
         FIG. 5A  is an enlarged schematic side view of the delivery system of  FIG. 2  along section B-B of  FIG. 4 ; 
         FIG. 5B  is an enlarged schematic side view of the delivery system of  FIG. 2  along section C-C of  FIG. 4 ; 
         FIG. 5C  is an enlarged schematic side view of the delivery system of  FIG. 2  along section D-D of  FIG. 4 ; 
         FIG. 5D  is an enlarged schematic side view of the delivery system of  FIG. 2  along section E-E of  FIG. 4 ; 
         FIG. 6A  is an enlarged perspective schematic view of section F-F across its center line showing an exemplary proximal implant end of the braid in communication with an exemplary pushing mechanism; 
         FIG. 6B  is an enlarged schematic overview showing an exemplary attachment system as between a delivery tube, pushing mechanism and catheter in an embodiment of the delivery system; 
         FIG. 6C  is an enlarged schematic view showing an exemplary attachment system as between a delivery tube, pushing mechanism and catheter in an embodiment of the delivery system. 
         FIG. 6D  is an enlarged schematic view showing an exemplary attachment system as between a delivery tube, pushing mechanism and catheter in an embodiment of the delivery system. 
         FIG. 6E  is an enlarged schematic view showing an exemplary attachment system as between a delivery tube, pushing mechanism with the catheter removed in an embodiment of the delivery system. 
         FIG. 6F  is an enlarged schematic view showing an exemplary attachment system as between a delivery tube, pushing mechanism with the catheter removed in an embodiment of the delivery system. 
         FIG. 7  is an enlarged schematic side view of the attachment system of  FIG. 6E  along section G-G. 
         FIG. 8  is a schematic side view of an exemplary delivery system with an occlusion device being deployed with an embolic coil. 
         FIG. 9  is a flow diagram for a method of delivering an occlusion device. 
         FIG. 10  is a flow diagram for a method of delivering an occlusion device using the herein disclosed delivery system. 
         FIG. 11A  depicts an example braid of this disclosure. 
         FIG. 11B  depicts an example braid of this disclosure deployed. 
         FIG. 11C  depicts an example braid with embolic coil of this disclosure. 
         FIG. 12A  is an enlarged view one step of an exemplary delivery system device being deployed into an aneurysm in accordance with this disclosure, wherein the system is shown moving from a collapsed condition to a deployed condition. 
         FIG. 12B  is an enlarged view one step of an exemplary delivery system device being deployed into an aneurysm in accordance with this disclosure, wherein the system is shown moving from a collapsed condition to a deployed condition. 
         FIG. 12C  is an enlarged view one step of an exemplary delivery system device being deployed into an aneurysm in accordance with this disclosure, wherein the system is shown moving from a collapsed condition to a deployed condition. 
         FIG. 12D  is an enlarged view one step of an exemplary delivery system device being deployed into an aneurysm in accordance with this disclosure, wherein the system is shown moving from a collapse 0 d condition to a deployed condition. 
         FIG. 12E  is an enlarged view one step of an exemplary delivery system device being deployed into an aneurysm in accordance with this disclosure, wherein the system is shown moving from a collapsed condition to a deployed condition. 
         FIG. 12F  is an enlarged view one step of an exemplary delivery system device being deployed into an aneurysm in accordance with this disclosure, wherein the system is shown moving from a collapsed condition to a deployed condition. 
         FIG. 12G  is an enlarged view one step of an exemplary delivery system device being deployed into an aneurysm in accordance with this disclosure, wherein the system is shown moving from a collapsed condition to a deployed condition. 
         FIG. 12H  is an enlarged view one step of an exemplary delivery system device being deployed into an aneurysm in accordance with this disclosure, wherein the system is shown moving from a collapsed condition to a deployed condition. 
         FIG. 12I  is an enlarged view one step of an exemplary delivery system device being deployed into an aneurysm in accordance with this disclosure, wherein the system is shown moving from a collapsed condition to a deployed condition. 
     
    
    
     DETAILED DESCRIPTION 
     Although example embodiments of the disclosed technology are explained in detail herein, it is to be understood that other embodiments are contemplated. Accordingly, it is not intended that the disclosed technology be limited in its scope to the details of construction and arrangement of components set forth in the following description or illustrated in the drawings. The disclosed technology is capable of other embodiments and of being practiced or carried out in various ways. 
     It must also be noted that, as used in the specification and the appended claims, the singular forms “a,” “an” and “the” include plural referents unless the context clearly dictates otherwise. By “comprising” or “containing” or “including” it is meant that at least the named compound, element, particle, or method step is present in the composition or article or method, but does not exclude the presence of other compounds, materials, particles, method steps, even if the other such compounds, material, particles, method steps have the same function as what is named. 
     In describing example embodiments, terminology will be resorted to for the sake of clarity. It is intended that each term contemplates its broadest meaning as understood by those skilled in the art and includes all technical equivalents that operate in a similar manner to accomplish a similar purpose. It is also to be understood that the mention of one or more steps of a method does not preclude the presence of additional method steps or intervening method steps between those steps expressly identified. Steps of a method may be performed in a different order than those described herein without departing from the scope of the disclosed technology. Similarly, it is also to be understood that the mention of one or more components in a device or system does not preclude the presence of additional components or intervening components between those components expressly identified. 
     As discussed herein, vasculature of a “subject” or “patient” may be vasculature of a human or any animal. It should be appreciated that an animal may be a variety of any applicable type, including, but not limited thereto, mammal, veterinarian animal, livestock animal or pet type animal, etc. As an example, the animal may be a laboratory animal specifically selected to have certain characteristics similar to a human (e.g., rat, dog, pig, monkey, or the like). It should be appreciated that the subject may be any applicable human patient, for example. 
     As discussed herein, “operator” may include a doctor, surgeon, or any other individual or delivery instrumentation associated with delivery of a braid body to the vasculature of a subject. 
     Cerebrovascular aneurysms are known to be treated using embolic coils, which are delivered to the aneurysm sack via a microcatheter and detached in situ. It is understood that “packing density” is the volume of the aneurysm sack occupied by the coil mass. In previous coil approaches, multiple coils (e.g. five coils) have been used to pack the aneurysms and the packing density can typically range between 15-25%, depending on the aneurysm size. The herein disclosed device improves on use of embolic coils by using a single device without a need for even a single coil to pack the device. Instead, the disclosed device is operable to seal the aneurysm neck and pack the aneurysm to a higher packing density than using coils. In practice, the packing density can be as increased 25-50% depending on the length of braid in the aneurysm, or double what can be achieved with conventional coils. However, the multiple braid layers formed as the braid packs the aneurysm may mean that a lower packing density may achieve blood flow alteration and coagulation in a way that a lower packing density may achieve the same level of occlusion. This allows for the aneurysm neck to heal. 
     In contrast, in previous embolic-based approaches, packing the aneurysm required in placement of coils into the aneurysm sack until the aneurysm obtained the desired packing density to occlude the aneurysm. However, obtaining such a packing density was difficult, time consuming, and aneurysm morphology (e.g. wide neck, bifurcation, etc.), and the like required ancillary devices such a stents or balloons to support the coil mass and obtain the desired packing density. Furthermore, aneurysms treated with multiple coils often reanalyze or compact as a result of poor coiling, lack of coverage across the aneurysm neck, as a result of flow, or even aneurysm size. 
     The occlusion device  1  and corresponding delivery system  30  disclosed herein addresses the drawbacks of previous approaches, including low packing density, compaction and recanalization of aneurysms. 
     Turning to  FIG. 1 , an example occlusion device  1  of this disclosure is shown deployed into an aneurysm A of blood vessel BV but not yet released from its delivery system. The catheter  20  has been delivered to the aneurysm A and as shown and discussed more particularly below, occlusive sack  12  of braided tubular implant  10  (hereinafter also referred to “braid” or “braid  10 ”) of device  1  has formed a predetermined shape and structure that outlines and supports the walls of the aneurysm A so as to occlude aneurysm A. 
       FIG. 2  depicts a schematic side view of braid  10  and delivery system  30  prior to being positioned in a location of interest in the vasculature for occluding aneurysm A. The braid  10  can include a lumen with a distal implant end  16  opposite a proximal implant end  14 , as shown more particularly in  FIG. 3 . Specifically,  FIG. 3  is an enlarged schematic side view of the delivery system of  FIG. 2  along section A-A prior to deployment. System  30  can include a pusher delivery tube  34  with an inner lumen and a braid pushing mechanism  38 . System  30  can deliver an occlusive device, which includes braid  10 , to a location of interest (e.g. a lesion site) using a microcatheter  20 . System  30  may be preplaced in microcatheter  20 . In certain embodiments, microcatheter  20  can be pre-placed, with or without system  30 , at a level of the aneurysm neck and used to track the device  1  to the lesion. Mechanism  38  may be tubular, solid, elongate, and/or be pliable to be able to pass through tortuous pathways of the vasculature within delivery tube  34  and/or microcatheter  20 . Mechanism  38  can include an inner lumen and be disposable or capable of functioning with a hypotube. For example, a hypotube can be attached or in communication with mechanism  38  to distally slide mechanism  38  toward the aneurysm A. 
     In this respect, mechanism  38  may be slidably disposed within delivery tube  34 , wherein mechanism  38  can be in mechanical connection with braid  10  at attachment  36 . When braid  10  is mechanically attached to pushing mechanism  38  at attachment  36 , distally translating, sliding, or otherwise moving mechanism  38  toward the aneurysm can cause a distal implant end  16  of braid  10  to begin moving from a collapsed condition to a deployed condition, as discussed below. Both delivery tube  34  and mechanism  38  can extend from the proximal  24  to the distal end  26  of microcatheter  20 . 
     It is understood that braid  10  can include a self-expanding braid for treating an aneurysm. The inner lumen of braid  10  can form a self-expanding multi-filament outer surface that can include a mesh. It can be seen that mechanism  38  is disposed proximal of braid  10  and braid  10  is in communication with mechanism  38  across attachment  36  at proximal implant end  14 . Braid  10  may be attached to attachment  36  by being crimped thereon or by a detachable connection. In certain embodiments, proximal implant end  14  may be inserted within the distal end of mechanism  38  at attachment  36  wherein mechanism  38  can then be attached therewith or thereon. However, attachment  36  is not so limited and instead braid  10  may be slidably, detachably inserted over or otherwise with attachment  36 . 
     Prior to deployment within an aneurysm A, distal implant end  16  of braid  10  is adjacent or in contact with distal end  46  of delivery tube  34 . Delivery tube  34  may also include one or more fasteners  32  operable to securely fasten braid  10  in place prior to deployment. The area of braid  10  of distal implant end  16  adjacent or in communication with fastener  32  may be substantially atraumatic and/or rounded so to minimize kinking or other damage to the adjacent area of braid  10 . Fastener  32  may include a crimping, soldering, bracing, adhesive, pressure cuff, welding, or other fastener means, including clamps, or the like, so that delivery tube  34  is secured therewith but translation of mechanism  38  and braid  10  is still permitted when actuation is desired. 
     Braid  10  may be operable to expand over the neck of the aneurysm A during delivery which can substantially reduce and/or prevent further blood flow from the parent vessel into the aneurysm sac. Portions of braid  10  on or proximate end  16  may be more pliable than portions of braid  10  on or proximate end  14  in order to induce self-expansion during delivery and inversion as braid  10  forms its predetermined, sack-like shape within aneurysm A (see, e.g.,  FIG. 1 ). The braid  10 , including its outer surface, can be self-expanding and made from nitinol with interwoven platinum filaments for radiopacity. Braid  10  is not so limited, however, and any material or combination of materials can be used to form an outer surface of braid  10  can be used as needed or required. 
     Turning to  FIG. 4 , a flow diagram for a method  400  is shown for safely and precisely delivering an example braid  10  to the vasculature. As can be seen, in step  405  of method  400 , the occlusion device  1  is assembled with a microcatheter  20 . The assembly between microcatheter  20  and device  1  can take place before being introduced into the vasculature. In step  410 , device  1 , including system  30 , may now have been selectively positioned at the lesion site and mechanism  38  can begin its distal translation of the braid  10 . As can be seen in step  410 , braid  10  begins expanding and/or inverting as its distal implant end  16  moves away from distal end  26  of catheter  20  and/or delivery end  46  (not identified in this figure) of delivery tube  34  to form sack  12  within aneurysm A being treated (see, e.g., formed sack  12  of device  1  that occludes aneurysm A of  FIG. 1 ). 
     In certain embodiments, sack  12  begins being formed as braid  10  is advanced to the vicinity of the neck or dome of the aneurysm such that mechanism  38 , attachment  36 , and/or portions of delivery tube  34  are at the level of the neck as seen under fluoroscopy. However, device  1  is not so limited and instead braid  10  can begin inverting and folding into itself to form sack  12  as distal implant end  16  simply distally slides away from delivery tube  34  and/or catheter  20 . As shown in step  415 , sack  12  is now taking a generally spherical shape as braid  10  is translated distally deeper into aneurysm A and/or further away from catheter  20  and tube  34 . In moving between steps  405  to  415 , the outer diameter of the braid  10  radially expands to a diameter greater than the microcatheter  20  as sack  12  is formed. The braid wire count of interstices of braid  10  that may form the outer surface can vary depending of the diameter of the sack  12  or sacks needed to occlude the aneurysm. For example, in order to induce formation of the predetermined shape and strength of sack  12 , distal implant end  16  of braid  10  may be more pliable than proximal implant end  14  and portions of braid  10  may vary from most pliable on or about end  16  and less pliable on or about end  14 . Interstices of braid  10  may also form openings for occlusion of the aneurysm. 
     Such distal movement of mechanism  38  and initial formation of sack  12  of braid  10  is more clearly shown in  FIG. 5A  which is an enlarged view of section B-B of  FIG. 4 . As distal implant end  16  of braid  10  distally translates toward aneurysm A and away from end  26  of microcatheter  20 , the distal implant end  16  of braid  10  can begin to invert and fold into itself thereby beginning to form an occlusive sack  12  for occluding an aneurysm. This is more clearly shown in  FIG. 5B , which is an enlarged view of section C-C of  FIG. 4 . Mechanism  38  may be driven by a hypotube from its proximal end by an operator or the like. It is understood that braid  10  can also be attached to and/or foldable over an inner portion of mechanism  38 , for example at attachment  36 . 
     In step  420 , mechanism  38  may continue to be distally translated while distal implant end  16  of braid  10  continues inverting as it approaches or contacts the dome of aneurysm A. Braid  10  can also begin inverting immediately as it exits catheter  20  (see, e.g., step  410  of  FIG. 5A ). It can be seen that sack  12  has now completely expanded into its predetermined, spherical shape designed to conform to the shape of aneurysm A. This is more clearly shown in  FIG. 5C  which is an enlarged view of section D-D, wherein sack  12  can be seen in the spherical shape. More specifically, in moving between steps  405  and  420  as shown between  FIGS. 5A-5C , mechanism  38  distally translates braid  10  until braid folds about its distal implant end  16  to form the sack  12 . Sack  12  may take on any shape necessary to occlude the respective aneurysm A. 
     Between steps  420  to  425 , mechanism  38  continues to distally slide until unexpanded, braid portion(s)  17  proximal of sack  12  folds and randomly fills sack  12 , as shown more particularly in  FIG. 5D , which is an enlarged view of section E-E. Sack  12  can be the depicted spherical shape and formed to impart a predetermined packing density and portion  17  which is formed with braid  10  has filled sack  12  to further reinforce sack  12 . In other words, as the braid  10  reaches the dome of the aneurysm, the braid portion(s)  17  proximal to sack  12  coming from mechanism  38  can be forced to deflect and start filling the sack  12  as shown starting in step  415 . 
     In step  430 , with the sack  12  fully formed in a manner sufficient to occlude aneurysm A, braid  10  can be detached from attachment  36 . However, if sack  12  is not precisely positioned or if needs to be reset within aneurysm A for safe occlusion without risk of rupture, braid  10 , including sack  12 , can be retracted back into delivery tube  34  by proximally moving mechanism  38 . It is understood that when sack  12  is fully formed, it is capable of packing aneurysm A with a 15-25% packing density without the need for any embolic coils. However, braid  10  can be designed to achieve a packing density of 40%, 50%, or less than 15-25%, as needed or required. The change in packing density can be affected by changing the length or diameter of the braid  10 . A longer or shorter braid  10  in the same aneurysm A can change the amount of braid deployed, which in turn can dictate the number of sacks  12  formed and the amount of unexpanded, braid portion  17  filling the sack  12 . The same can hold true for the diameter of the braid  10 , a larger diameter filling more of the aneurysm A in less length, but at a lower density. The operator can then choose between the differing parameters of a braid  10  for each particular aneurysm A. 
     In step  435 , because sack  12  has been properly positioned and formed within aneurysm A, braid  10  has been detached from mechanism  38  and mechanism  38  can now be retracted therefrom. As shown, opposing grasper arms  42   a ,  42   b  can be formed with the microcatheter  20  or delivery tube  34  and withdrawn proximally so arms  42   a ,  42   b  can release sack  12  formed by expanding braid  10 . It is understood that some or all of arms  42   a ,  42   b  can be radiopaque so that positioning and detachment can be monitored and/or driven under fluoroscopy. 
     One example of attachment  36  is shown in  FIG. 6A  which is an enlarged perspective schematic view of section E-E of step  425  across center line in order to show braid  10  in communication with mechanism  38 . It can be seen that mechanism  38  may include a pull wire  39  that hooks into or attaches to braid  10  and similarly can be released therefrom and that attachment will be secure so long as pull wire  39  is not pulled proximally. If pull wire  39  is pulled back braid  10  can be released.  FIG. 6A  is merely one way that mechanism  38  may attach to braid  10  across attachment  36  and any number of attachment means are contemplated as needed or required. 
     Another example of how system  30  may release braid  10  is shown in  FIG. 6B . In a first step  605 B of method  600 B, mechanism  38 ′ is shown in a collapsed condition within delivery tube  34 ′ and catheter  20 . Mechanism  38 ′ includes a substantially elongate portion  37 ′ that generally runs along the inner cavity or lumen of tube  34 ′ leaving a space between the elongate portion  37 ′ and the tube  34 ′. Portion  37 ′ may be axially aligned with tube  34 ′. A base portion  33 ′ of mechanism  38 ′ may also be included disposed on a proximal end of mechanism  38 ′. Portion  33 ′ may at least be wider than portion  37 ′ and can extend to the inner surface of tube  34 ′. During use, braid  10  can be axially positioned over the space between portion  37 ′ and tube  34 ′, advanced over portion  37 ′, and secured to portion  33 ′. In step  610 B, it can be seen that mechanism  38 ′ has been distally translated so that portion  37 ′ is now distal of tube  34 ′ and catheter  20 . Base  33 ′ has similarly been distally translated until it contacts protrusions  41 ′ of tube  34 ′. When base  33 ′ contacts protrusion  41 ′ in step  610 B, protrusion  41 ′ will be distal of tube  34 ′ so that proximal implant end  14  of braid  10  is free to detach. Protrusion  41 ′ may also include a gap or space  43 ′ into which end  14  of braid  10  can be attached. When space  43 ′ is distal of catheter  20  and tube  34 ′, in those embodiments where end  14  was previously fastened at space  43 ′, end  14  may now freely disengage and release. 
     Protrusions  41 ′ may be members or extensions of tube  34 ′ that inwardly protrude to reduce the inner diameter thereabout to be less than a diameter of base  33 ′. In this regard, only one protrusion  41 ′ may be provided integrally formed with tube  34 ′ or detachably connected and positioned therewith. However, method  600 B is not so limited and more than one protrusion  41 ′ can be provided as well as a cylindrical protrusion  41 ′, or any other protrusion shaped and designed to reduce the inner diameter to prevent base  33 ′ from moving passed. 
     Another example of how system  30  may release braid  10  is shown in  FIG. 6C - FIG. 6F . In  FIG. 6C , a schematic is shown of an exemplary prototype.  FIG. 6D  is a photograph of an exemplary prototype exemplifying the embodiment shown in  FIG. 6C . Braid  10  is depicted in both  FIGS. 6C and 6D  in a deployed condition wherein sack  12  is formed distal of catheter  20  and tube  34 ″. Mechanism  38 ″ in this embodiment is mechanically attached to braid  10  via attachment  36 ″, as more clearly shown in  FIGS. 6E and 6F . Specifically, in  FIG. 6E , catheter  20  has been removed to show braid  10  interconnected with mechanism  38 ″ at attachment  36 ″. In  FIG. 6F ., mechanism  38 ″ has been detached from braid  10 . In practice, mechanism  38 ″ and catheter  20  can now be removed from the vasculature and from the patient altogether leaving occlusive sack  12  selectively positioned and formed to occlude aneurysm A. 
     Attachment  36 ″ is more clearly shown in  FIG. 7  which is an enlarged perspective schematic view of section G-G of  FIG. 6E  showing end  14  of braid  10  in communication with mechanism  38 ″. It can be seen that mechanism  38 ″ may include a releasable attachment interface formed by an interlinking member  39 ″ about its distal end  46 . Member  39 ″ may be integrally formed with mechanism  38 ″ and be constructed from a recess or channel portion operable to securely engage with attachment portion  11  of braid  10 . Portion  11  may in turn be a separate portion fastened to, formed with, or otherwise disposed on end  14  of braid  10 . Portion  11  may include a corresponding channel or recess operable to detachably, securely engage with member  39 ″. In practice, member  39 ″ may be securely engaged with portion  11  within delivery tube  34  prior to delivery to the vasculature. However, the mechanism  38 ″ and braid  10  are not so limited and engagement can occur contemporaneous with delivery of system  30  being delivered to the vasculature. When the operator desires to deliver and release sack  12  with aneurysm A, braid  10  may be advanced distally from catheter  20  and/or delivery tube  34  by moving mechanism  38 ″. Once member  39 ″ is distal of tube  34 , corresponding portion  11  of braid  10  can be released therefrom. Mechanism  38 ″ can then be retracted and system  30  can be removed from the location of interest in the vasculature. It is understood that  FIG. 7  is merely one way that a pushing mechanism of the herein disclosed system  30  may attach and detach to end  14  of braid  10  across attachment  36 ″ and any number of attachment means are contemplated as needed or required. 
       FIG. 8  is a schematic side view of another example delivery system  30  with device  1  in the process of being deployed and sack  12  in the process of being formed. In this embodiment, a coil  33  is also assembled with the delivery system  30  for later filling sack  12  to further facilitate packing of aneurysm A. It is understood that one or more additional coils can be inserted with proximal implant end  14  as needed or required. System  30  is not so limited, however, and braid  10  can include portions behind sack  12  that do not invert to form a sack. Instead, these aft portions are capable of being slid distally into formed sack  12  similar to adjusting a packing density delivered by sack  12  (see, e.g.,  FIGS. 12A-12I ). 
       FIG. 9  is a flow diagram for a method  900  of delivering an occlusion device. In step  905 , a self-expanding braid inverts as it distally translates from a delivery catheter into the aneurysm. In step  910 , the braid forms an occlusive sack that conforms to the size and/or shape of the aneurysm. The braid may invert and/or radially expand in step  910  to form the occlusive sack. In step  915 , the braid continues distally translating and when the braid reaches the top of the aneurysm, portions of the braid cease inverting (e.g., portions of the braid proximal the occlusive sack) and are in a non-inverted condition. In some embodiments, portions of the braid proximal the occlusive sack are in a non-inverted condition (e.g., unexpanded) as the braid is distally translated deeper into the aneurysm. In step  920 , the portions of the braid in the non-inverted condition distally translate and fill the occlusive sack inside the aneurysm to a predetermined packing density. The density can be increased at least 25%, between 25-50%, or as much as 75% more than existing coil approaches. 
       FIG. 10  is a flow diagram for a method  1000  of delivering an occlusion device using the herein disclosed delivery system. Step  1005  includes selectively positioning a microcatheter in the vasculature. Step  1010  includes slidably positioning a delivery system of the occlusion device within the microcatheter, the delivery system comprising a delivery tube comprising a distal end and a proximal end and a pushing mechanism slidably disposed within the delivery tube, the pushing mechanism comprising a distal end and a proximal end. Step  1015  includes slidably positioning a self-expanding braid of the occlusion device within the delivery tube, the braid comprising a distal end and a proximal end. Step  1020  includes detachably attaching the proximal end of the braid to the distal end of the pushing mechanism. Step  1025  includes advancing the delivery system to the vasculature to the aneurysm. Step  1030  includes distally sliding the braid, by the pushing mechanism, in the delivery tube toward the aneurysm thereby causing the braid to invert and/or radially expand whiling moving from a collapsed condition within the delivery tube to a deployed condition within the aneurysm as the distal end of the braid is moved outside and away from the distal end of the delivery tube. Step  1035  includes releasing the occlusion device and withdrawing the delivery system and the catheter from the patient. 
       FIGS. 11A and 11B  illustrate an example of the braid, or braided mesh  100 . The mesh  100  can be self-expanding and which can be comprised of a tube of mesh. The self-expanding mesh  100  can include multiple wires  102 , for example from 4 to 96 wires. The number of wires  102 , and the diameter of the wires can be a factor in controlling the stiffness and pore size. y. For example, the distal end of the braid can more porous or more flexible than the proximal end, or vice versa. The combination of a braid with only one sack or multiple sacks (e.g., two or more sacks) can be taken into account when determining the number of wires. Fewer wires  102  can be used as a whole and still result in desired occlusion. The wires  102  can be made from multiple alloys such as a nickel-titanium alloy, cobalt chromium alloys, Platinum, Nitinol, Stainless Steel, Tantalum, or other alloys, or any other suitable biocompatible materials, or combination of these materials, including deposited thin films. Also, these materials can be absorbable or non-absorbable by the patient over time. 
     The apertures  104  in the mesh  100  create a substantially unitary frame work or mesh in the wall  106 . Thus, the apertures  104  may be of any size, shape, or porosity, and may be uniformly or randomly spaced throughout the wall  106  of the mesh  100 . The apertures  104  provide the tubular element with flexibility and also assist in the transformation of the mesh  100  from the collapsed state to the expanded state, and vice versa. 
     As discussed above, the mesh  100  inverts as it forms. This means that the inside  108  of the mesh  100  when the mesh is formed, becomes the “outside” on deployment or is in contact with the aneurysm A wall, as illustrated in  FIG. 11B . For clarity, the mesh  100 , is initially formed as a hollow cylindrical shape. This shape has an inside  108  and an outside. The inside  108  being akin to the hollow portion of a tube. Upon deployment, the mesh  100  is turned inside-out so the “inside”  108  on formation is now the “outside” of the sack  112  once deployed in the aneurysm A. 
     Note that the mesh  100  has a length L and that length L forms both the sack  112  and the unexpanded mesh  110  (or “tail”) that forms within the sack  112 . Controlling the length L can provide differing diameters of the sack  112 , the number of internal sacks and/or the length of the tail  110  that fills the sack  112  and affects packing density. 
     In one example, the inversion of the mesh  100  can be formed when the proximal end  114  of the mesh  100  is pushed forward while the distal end  116  remains fixed. The proximal end  114  is pushed inside  108  forcing the proximal end  114  to exit the delivery tube first while end  116  remains fixed. Once the entire length L is deployed out of the delivery tube, the distal end  116  is detached and is thus the last end to be deployed. As above, the proximal end  114  engages the proximal implant end  14  and the distal end  116  engages the distal implant end  16 . The mesh  100  can be formed akin to a tube sock. 
     Another example fixes the distal end  116  as above, and as the proximal end  114  is pushed, the mesh  110  just behind the distal end  116  is deployed, still causing the mesh  100  to deploy “inside out.” Here, once the mesh  100  is fully deployed, both the proximal and distal ends  114 ,  116  are next to each other. 
       FIG. 11C  illustrates the mesh  100  post-deployment with an embolic coil  330  at the proximal end  114  which can be opened. With end  114  being opened, the embolic coil  330  may be inserted therethrough to increase packing density of the corresponding occlusive sack or otherwise support the occlusive sack in certain aneurysm morphologies, such as aneurysms with wide necks. Coil  330  be made with any biocompatible materials commonly used in the art such as nickel-titanium alloy, cobalt chromium alloys, Platinum, Nitinol, Stainless Steel, Tantalum, or other alloys; or any other suitable biocompatible materials, or combination of these materials. The stiffness of the coil  330  can be adjusted by, for example, typical coil parameters of coil wire diameter, coil wound diameter, coil pitch, and coil material. In the instance of a coil, the diameter of the coil is selected in consideration of the size and shape of the aneurismal sac A, which can be a variety of shapes and sizes. 
       FIGS. 12A-12I  depict example embodiments of braid  10  being delivered to an example aneurysm A. Specifically, in  FIG. 12A , braid  10  can be seen being initially advance into aneurysm A and sack  12  beginning to take shape. In  FIG. 12B , it can be seen that braid  10  continues to be distally advanced toward dome D of aneurysm A and folds into itself to form sack  12 . However, braid  10  is not so limited and in certain embodiments as braid  10  exits catheter  20 , braid  10  can begin inverting to form sack  12  without a break  13  and independent of its position relative to dome D. “The term “break” is used herein to include a region of the braid that facilitates inversion and/or avoid kinking of the braid during delivery. The break can include one or more local changes in physical properties with respect to other regions of the braid (e.g., increased flexibility, pre-weakened, etc.). Sack  12  is radially expanding toward the walls of aneurysm A while unexpanded portions  17  of braid  10  continue to be translated. It is understood that break  13  may be formed into the interstices of braid  10  so that inverted, folding occurs after braid  10  has distally translated a predetermined distance. Break  13  may include localized heat treatment to render braid  10  more ductile but kink  243382 . 000323  DSP 5326 USCNT 2  preventative and induce a gradual folding curve. In this respect, the break  13 , including localized heat treatment, can render braid  10  capable of expanding after inverting. Break  13  may also be simply be a weak point or buckling point pre-set for a particular sack  12  so that buckling is induced so as to avoid strain of aneurysm A. Alternatively, no break  13  may be included and instead braid  10  may invert and fold into itself upon contacting the dome D of aneurism A based on pre-selected pliability of braid  10 . 
     In certain embodiments, sack  12  can be sized for only a specific sized aneurysm A. However, in other embodiments, sack  12  can be conformable or adjusted by the operator to sufficiently pack aneurysms across multiple sizes (e.g. across approximately 6 mm to approximately 10 mm) by continuing to advance portion  17  so that sack  12  is adjusted, as needed. For example, translating portion  17  distally from first to second positions can adjust from a first occlusion setting to a second setting. This is particularly advantageous in a clinical setting since it means that accurate measuring of aneurysm A is unnecessary and instead, sack  12  can be precisely and safely adjusted to fit aneurysm A in a manner that occludes without risk of rupture. 
     In  FIG. 12C , sack  12  is nearly fully formed and in  FIG. 12D , portions  17  have been distally translated so that sack  12  is fully formed with no additionally portions necessary to expand. In  FIG. 12D  specifically, it can be seen that formed sack  12  is now adjacent and supporting dome D. Braid  10  meanwhile may continue to be translated to form one or more additional sacks internal to sack  12  in order to overlay sack  12  to decrease porosity and/or further slow flow into the aneurysm. For example, in  FIG. 12E , a second break may be included in braid  10  so that as portion  17  continues to be translated distally, a second sack  15  can begin to form and invert into itself. In  FIG. 12F , portion  17  has distally translated more so that second sack  15  is now fully formed and overlaid internal to sack  12 . In  FIGS. 12G-12I , after formation of sacks  12 ,  15 , portion  17  may continue to be distally translated while other portions of braid  10  no longer invert. In this respect, portion  17  can be considered a non-inverted portion of braid  10  proximal of sacks  12 ,  15 . Portion  17  distally translates to fill sack  15  with portions  17 , similar to a coil approach. However, unlike a coil approach, portions  17  can both fill sacks  12 ,  15  and then be retracted therefrom if an operator desires to re-position or re-set braid  10  with aneurysm A. The packing density of sack  12  can be adjusted by distally or proximally advancing portions  17  between one or more predetermined (e.g. a first setting of 15%, a second setting of 20%, a third setting of 25% etc). Rates of fluid occlusion can also be optimized by varying porosity throughout braid  10 , including ends  14 ,  16 , portion  17 , and/or sacks  12 ,  15 . The depicted embodiments here are merely example approaches of the herein disclosed braid  10 . Other embodiments could include only one occlusive sack or more than two example occlusive sacks as depicted. 
     It is understood that variations of the braid  10  can include various materials such as stainless steel, bio absorbable materials, and polymers. Braid  10 , including any specific portions such as any breaks and corresponding sacks, can be heat set to various configurations such as spherical, oblong, saddle shaped, etc. for the purpose of shaping the initial sack to better match the aneurysm morphology. In addition, the braid  10  can be heat shaped to include weak points to facility the braid buckling once it reaches the dome of the aneurysm. 
     It is also understood that any sack formed by the herein discussed braids  10  can be in a spherical shape as depicted or any other shape, as needed or required, such as ellipsoidal, heart-shaped, ovoid, cylindrical, hemispherical, or the like. Further, interstices of braid  10  that form the sack can vary, or be selectively designed, in size or shape along its length depending on how much braid  10  is caused to radially expand as pushing mechanism  38  is distally moved. 
     The specific configurations, choice of materials and the size and shape of various elements can be varied according to particular design specifications or constraints requiring a system or method constructed according to the principles of the disclosed technology. Such changes are intended to be embraced within the scope of the disclosed technology. The presently disclosed embodiments, therefore, are considered in all respects to be illustrative and not restrictive. It will therefore be apparent from the foregoing that while particular forms of the disclosure have been illustrated and described, various modifications can be made without departing from the spirit and scope of the disclosure and all changes that come within the meaning and range of equivalents thereof are intended to be embraced therein. 
     ASPECTS OF THE INVENTION 
     
         
         1. A vaso-occlusive device having a delivery configuration when restrained within a delivery catheter and a deployed configuration when released from the delivery catheter into an aneurysmal sac, the vaso-occlusive device comprising:
       a tubular structure, comprising:
           a distal portion configured to form a first sack within the aneurysmal sac when distally deployed from the delivery catheter into the aneurysmal sac,   a proximal portion configured to form a second sack within the first sack when distally deployed from the delivery catheter, thereby creating multi-layer   
           scaffolding within the aneurysmal sac; and   an elongate embolic element coupled to proximal end of the tubular structure,
 
wherein the elongate embolic element is configured to fill an interior region of the multi-layer scaffolding when distally deployed from the delivery catheter into the aneurysmal sac.
   
     
         2. The vaso-occlusive device of aspect 1, wherein the tubular structure comprises a tubular braided mesh. 
         3. The vaso-occlusive device of aspect 1 or 2, wherein the elongate embolic element comprises a braided ribbon. 
         4. The vaso-occlusive device of any preceding aspect, wherein the elongate embolic element comprises an embolic coil. 
         5. The vaso-occlusive device of any preceding aspect, wherein at least one of the distal portion and the proximal portion is configured to invert upon movement of the vaso-occlusive device from the delivery configuration to the deployed configuration. 
         6. The vaso-occlusive device of aspect 5, wherein the tubular structure further comprises an inflection region between the distal portion and the proximal portion, the inflection region configured to urge the inversion of the proximal portion and/or urge the inversion of the distal portion. 
         7. The vaso-occlusive device of aspect 6, wherein the inflection region is configured for urging the inversion of the proximal portion and/or the distal portion while the vaso-occlusion device moves from the delivery configuration to the deployed configuration in free-space. 
         8. The vaso-occlusive device of any preceding aspect, wherein each of the distal portion and the proximal portion is configured for self-expanding into a spherical, oblong, or saddle shape. 
         9. The vaso-occlusive device of any preceding aspect, wherein the distal portion comprises a non-expanding terminal end. 
         10. An implant configured to traverse vasculature within a delivery catheter and move from a delivery configuration with restrained by the delivery catheter to a deployed configuration within a spherical cavity, the implant comprising:
       an expandable tubular braid comprising a first portion configured to form a first sack conformal to walls of the spherical cavity and a second portion configured to form a second sack within the first sack when the implant moves from the delivery configuration to the deployed configuration; and   an elongate embolic element coupled to the tubular braid and configured to be positioned within the first sack and the second sack when the implant moves from the delivery configuration to the deployed configuration.   
     
         11. The implant having aspect 10, wherein the elongate embolic element comprises a braided ribbon. 
         12. The implant of aspect 10 or 11, wherein the elongate embolic element comprises an embolic coil. 
         13. The implant of any of aspects 10 through 12, wherein at least one of the first portion and the second portion is configured to invert upon movement of the implant from the delivery configuration to the deployed configuration. 
         14. A method of treating an aneurysm in a patient, the method comprising:
       distally advancing a vaso-occlusive device in a delivery configuration through a delivery catheter to an aneurysm neck, the vaso-occlusive device comprising a tubular structure and an elongated embolic element coupled to a proximal end of the tubular structure;   deploying a distal portion of the tubular structure from a distal end of the delivery catheter into a sac of the aneurysm;   expanding the distal portion of the tubular structure, thereby creating a single-layer scaffolding that lines a wall of the aneurysm sac;   deploying a proximal portion of the tubular structure from the distal end of the delivery catheter;   expanding the proximal portion of the tubular structure within the expanded distal portion of the tubular structure, thereby creating a multi-layer scaffolding that lines the wall of the aneurysm sac; and   positioning the elongated embolic element within the multi-layer scaffolding.   
     
           15 . The method of aspect 14, wherein the tubular structure comprises a tubular braided mesh. 
           16 . The method of aspect 14 or 15, wherein the elongate embolic element comprises an embolization coil and/or a braided ribbon. 
           17 . The method of any of aspects 14 through 16 further comprising:
       inverting at least of the distal portion and the proximal portion upon deployment of the tubular structure from the distal end of the delivery catheter.     
         18. The method of aspect 17, wherein the tubular structure further comprises an inflection region between the distal portion and the proximal portion, the inflection region configured to urge the inversion of the proximal portion and/or urge the inversion of the distal portion. 
         19. The method of aspect 18, wherein inversion of the tubular structure at the inflection region is initiated absent an application of an opposing proximal force on the tubular structure by a dome of the aneurysmal sac.
 
20. The method of any of aspects 14 through 19, further comprising:
       expanding each of the distal portion and the proximal portion respectively into a spherical, oblong, or saddle shape.