Patent Publication Number: US-2022211988-A1

Title: Devices and methods for treating the skin

Description:
PRIORITY AND CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application is a continuation of U.S. patent application Ser. No. 16/246,306, filed on Jan. 11, 2019 and issued as U.S. Pat. No. 11,224,728 on Jan. 18, 2022, which is a continuation of U.S. patent application Ser. No. 15/498,416, filed on Apr. 26, 2017 and issued as U.S. Pat. No. 10,179,229 on Jan. 15, 2019, which is a continuation-in-part (CIP) of U.S. patent application Ser. No. 15/354,754, filed on Nov. 17, 2016, which is a continuation of U.S. patent application Ser. No. 14/998,375, filed on Dec. 23, 2015 and issued as U.S. Pat. No. 9,498,610 on Nov. 22, 2016, which claims the priority benefit of U.S. Provisional Application No. 62/096,493, filed on Dec. 23, 2014, and U.S. Provisional Application No. 62/235,479, filed Sep. 30, 2015. U.S. patent application Ser. No. 15/498,416, filed on Apr. 26, 2017, also claims the priority benefit of U.S. Provisional Application 62/328,596, filed Apr. 27, 2016. The entireties of all of the foregoing are bodily incorporated herein and made part of the present application. 
    
    
     BACKGROUND 
     Field 
     This application relates generally to skin treatment, and more specifically, to apparatuses, systems and methods for treating a person&#39;s skin using one or more porous members, rollerballs and/or the like. 
     Description of the Related Art 
     Abrasion of the outer layer or epidermis of the skin is desirable to smooth or blend scars, blemishes, or other skin conditions that may be caused by, for example, acne, sun exposure, and aging. Standard techniques used to abrade the skin have generally been separated into two fields referred to as dermabrasion and microdermabrasion. Both techniques remove portions of the epidermis called the stratum corneum, which the body interprets as a mild injury. The body then replaces the lost skin cells, resulting in a new outer layer of skin. Additionally, despite the mild edema and erythema associated with the procedures, the skin looks and feels smoother because of the new outer layer of skin. In some arrangements, skin can be treated by delivering one or more substances to the skin. In some instances, the application of suction along the skin surface can further enhance a skin treatment procedure. 
     SUMMARY 
     According to some embodiments, a skin treatment assembly comprises a tip comprising a proximal end and a distal end, a container configured to secure to the tip along the proximal end of the tip, wherein the container is configured to contain a liquid, and a porous member configured to extend at least partially within an interior of the container such that it contact a liquid contained within the container, wherein the porous member is configured to extend at least partially within an interior of the tip and is configured to facilitate the transfer of liquid from the container to the distal end of the tip. 
     According to some embodiments, the porous member comprises a wicking material. In some embodiments, the porous member is removable and replaceable relative to the tip and the container. In one embodiment, the porous member is rigid or semi-rigid. 
     According to some embodiments, the porous member comprises at least one internal reservoir or region. In some arrangements, the internal reservoir or region is configured to be at least partially hollow. In one embodiment, the internal reservoir or region is configured to contain at least one flexible or other member. In some embodiments, the at least one flexible or other member comprises a felt or another absorbent material or member. 
     According to some embodiments, at least one treatment material is positioned within the internal reservoir or region, wherein the at least one treatment material is configured to at least partially dissolve or release in the presence of a liquid. In some embodiments, at least one treatment material is positioned within the porous member, wherein the at least one treatment material is configured to at least partially dissolve or release in the presence of a liquid. 
     According to some embodiments, at least one treatment material is positioned along or near the tip, wherein the at least one treatment material is configured to at least partially dissolve or release in the presence of a liquid. 
     According to some embodiments, the assembly further comprises at least one suction passageway that extends to or near the tip, wherein the at least one suction passageway is configured to be placed in fluid communication with a suction source to selectively create suction along the distal end of the tip. 
     According to some embodiments, the tip comprises at least one abrasive member or structure configured to at least partially abrade skin when the assembly is moved relative to skin tissue during a treatment procedure. 
     According to some embodiments, a skin treatment assembly comprises a handpiece comprising a distal end, the handpiece comprising a recess or cavity configured to receive a cartridge or other fluid container, a tip configured to be positioned along the distal end of the handpiece, the tip being configured to contact a skin surface of a subject during use, at least one rollerball configured to extend to or near the tip, wherein the at least one rollerball is configured to be in fluid communication with an interior of a cartridge or other fluid container secured to the handpiece, wherein the at least one rollerball is configured to contact the skin surface of the subject during use and to facilitate the delivery of fluids to said skin surface as the rollerball is moved relative to said skin surface, at least one suction conduit extending to the tip, wherein the at least one suction conduit is configured to be placed in fluid communication with a vacuum source to selectively apply suction to the tip during use, and at least one abrasive structure or member located on, near or along the tip, the at least one abrasive structure or member being configured to selectively exfoliate the subject skin during use. 
     According to some embodiments, the rollerball is secured to a distal end of the cartridge or other fluid container. In some embodiments, the rollerball is secured to the handpiece. In some embodiments, the rollerball is secured to the tip. In one embodiment, the rollerball is in direct fluid communication with the interior of the cartridge or other fluid container. In some embodiments, the rollerball is in indirect fluid communication with the interior of the cartridge or other fluid container. In some embodiments, the rollerball is in fluid communication with the interior of the cartridge or other fluid container via one or more fluid conduits or passages. 
     According to some embodiments, the area proximal to the at least one rollerball comprises one or more vanes that increase an effective surface area of an area immediately adjacent the at least one rollerball along or near the cartridge or other fluid container to help maintain fluids from the cartridge or other fluid container immediately adjacent the at least one rollerball. In some embodiments, the assembly further comprises a porous member immediately adjacent the at least one rollerball to ensure that fluid from the cartridge or other fluid container is placed in fluid communication with the at least one rollerball. 
     According to some embodiments, the tip comprises a peripheral lip, wherein the peripheral lip is sized, shaped and configured to contact a subject&#39;s skin tissue and generally form a seal along said skin tissue. In one embodiment, the at least one rollerball is positioned within an interior of the peripheral lip and extends to a height below the height of the peripheral lip. According to some embodiments, the cartridge or other fluid container is configured to be re-used during a subsequent treatment procedure. 
     According to some embodiments, a skin treatment assembly comprises a handpiece comprising a distal end, the handpiece being configured to receive a cartridge or being configured to be placed in fluid communication with a fluid source, a tip configured to be positioned along the distal end of the handpiece, the tip being configured to contact a skin surface of a subject during use, a rollerball configured to extend to or near the tip, wherein the rollerball is configured to be in fluid communication with an interior of a cartridge or other fluid container secured to the handpiece, wherein the rollerball is configured to contact the skin surface of the subject during use and to facilitate the delivery of fluids to said skin surface as the rollerball is moved relative to said skin surface, and at least one abrasive structure or member located on, near or along the tip, the at least one abrasive structure or member being configured to selectively exfoliate the subject skin during use. 
     According to some embodiments, the assembly further comprises at least one suction conduit extending to or near the tip, wherein the at least one suction conduit is configured to be placed in fluid communication with a suction source to selectively apply suction to the tip during use. In some embodiments, the rollerball is secured to a distal end of the cartridge or other fluid container. In one embodiment, the rollerball is secured to the handpiece. In some arrangements, the rollerball is secured to the tip. 
     According to some embodiments, the rollerball is in direct or indirect fluid communication with the interior of the cartridge or other fluid container. In some embodiments, the assembly further comprises a porous member adjacent (e.g., immediately adjacent) the at least one rollerball to ensure that fluid from the cartridge or other fluid container is placed in fluid communication with the at least one rollerball. In some embodiments, the tip comprises a peripheral lip, wherein the peripheral lip is sized, shaped and configured to contact a subject&#39;s skin tissue and generally form a seal along said skin tissue. 
     According to some embodiments, a skin treatment assembly comprises a handpiece comprising a distal end, the handpiece being configured to receive a fluid container, a tip positioned along the distal end of the handpiece, the tip being configured to contact a skin surface of a subject during use, at least one porous member configured to extend to or near the tip, wherein the at least one porous member is configured to be in fluid communication with an interior of a fluid container secured to the handpiece, wherein the at least one porous member is configured to contact the skin surface of the subject during use and to facilitate the delivery of fluids to said skin surface as the at least one porous member is moved relative to said skin surface, at least one suction conduit extending to the tip, wherein the at least one suction conduit is configured to be placed in fluid communication with a vacuum source to selectively apply suction to the tip during use, and at least one abrasive structure or member located on, near or along the tip, the at least one abrasive structure or member being configured to selectively exfoliate the subject skin during use. 
     According to some embodiments, the at least one porous member is secured to a distal end of the cartridge or other fluid container. In some embodiments, the at least one porous member comprises a wicking material. In some embodiments, the at least one porous member is secured to the handpiece. In some embodiments, the at least one porous member is secured to the tip. In one embodiment, the at least one porous member is in direct fluid communication with the interior of the cartridge or other fluid container. 
     According to some embodiments, the at least one porous member is in indirect fluid communication with the interior of the cartridge or other fluid container. In some embodiments, the at least one porous member is in fluid communication with the interior of the fluid container via one or more fluid conduits or passages. In one embodiment, the tip comprises a peripheral lip, wherein the peripheral lip is sized, shaped and configured to contact a subject&#39;s skin tissue and generally form a seal along said skin tissue. In some embodiments, the cartridge or other fluid container is configured to be re-used during a subsequent treatment procedure. 
     According to some embodiments, a skin treatment assembly comprises a handpiece comprising a distal end, the handpiece being configured to receive a fluid container, a tip positioned along the distal end of the handpiece, the tip being configured to contact a skin surface of a subject during use, a porous member configured to extend to or near the tip, wherein the porous member is configured to be in fluid communication with an interior of a fluid container secured to the handpiece, wherein the porous member is configured to contact the skin surface of the subject during use and to facilitate the delivery of fluids to said skin surface as the porous member is moved relative to said skin surface, and at least one suction conduit extending to the tip, wherein the at least one suction conduit is configured to be placed in fluid communication with a vacuum source to selectively apply suction to the tip during use. 
     According to some embodiments, the at least one porous member is secured to a distal end of the cartridge or other fluid container. In some embodiments, the at least one porous member comprises a wicking material. In one embodiment, the at least one porous member is secured to the handpiece. In some embodiments, the at least one porous member is secured to the tip. In some embodiments, the at least one porous member is in direct fluid communication with the interior of the cartridge or other fluid container. In some embodiments, the at least one porous member is in indirect fluid communication with the interior of the cartridge or other fluid container. In some embodiments, the at least one porous member is in fluid communication with the interior of the fluid container via one or more fluid conduits or passages. 
     According to some embodiments, the assembly further comprises at least one abrasive structure or member located on, near or along the tip, the at least one abrasive structure or member being configured to selectively exfoliate the subject skin during use. In some embodiments, the at least one abrasive structure or member comprises a ridge or portion comprising a sharp surface. 
     According to some embodiments, a method of treating a skin surface of a subject comprises conducting a first skin treatment procedure on a subject at a professional facility, wherein the first skin treatment procedure comprises skin treatment using a handpiece, the handpiece comprising a tip and a removable cartridge, the tip being configured to contact a skin surface of a subject during use, wherein a rollerball is configured to extend to or near the tip, wherein the rollerball is configured to be in fluid communication with an interior of a cartridge or other fluid container secured to the handpiece, wherein the a rollerball is configured to contact the skin surface of the subject during use and to facilitate the delivery of fluids to said skin surface as the rollerball is moved relative to said skin surface, at least partially exfoliating a skin surface of a subject at the professional facility by moving the tip relative to the subject&#39;s skin surface, providing the cartridge or other fluid container to the subject following the first skin treatment procedure, and instructing the subject to conduct a second skin treatment procedure following the first skin treatment procedure, wherein the second skin treatment procedure is performed by the subject, the second skin treatment procedure comprising providing delivering a volume of fluids from the cartridge or other fluid container to a skin surface of the subject. 
     According to some embodiments, the method further comprises a third skin treatment procedure following the second skin treatment procedure, wherein the third skin treatment procedure is performed at a professional facility. In some embodiments, the subject brings the cartridge or other fluid container to the professional facility. In some arrangements, the second skin treatment procedure does not comprise exfoliation. In one embodiment, the second skin treatment procedure comprises only fluid delivery to the skin surface of the subject. 
     According to some embodiments, the first skin treatment procedure comprises skin exfoliation, wherein the tip comprises at least one abrasive surface configured to at least partially exfoliate skin when the handpiece is moved relative to the subject&#39;s skin. In some arrangements, the at least one abrasive surface comprises at least one sharp surface along the tip. In one embodiment, the at least one sharp surface comprises a spiral member extending distally from a base surface of the tip. In some arrangements, the at least one sharp surface comprises a post member extending distally from a base surface of the tip. In some embodiments, the cartridge or other fluid container comprises a cap to protect the rollerball following the first and second skin treatment procedures. 
     According to some embodiments, a method of treating a skin surface of a subject includes conducting a first skin treatment procedure on a subject at a treatment facility, wherein the first skin treatment procedure comprises skin treatment using a handpiece, the handpiece comprising a tip and a cartridge configured to be positioned along the distal end of the handpiece, the tip being configured to contact a skin surface of a subject during use, wherein at least one of a rollerball and a porous member is configured to extend to or near the tip, wherein the at least one of a rollerball and a porous member is configured to be in fluid communication with an interior of a cartridge or other fluid container secured to the handpiece, wherein the at least one of a rollerball and a porous member is configured to contact the skin surface of the subject during use and to facilitate the delivery of fluids to said skin surface as the rollerball or porous member is moved relative to said skin surface, at least partially exfoliating a skin surface of a subject at the treatment facility by moving the tip relative to the subject&#39;s skin surface; 
     providing the cartridge or other fluid container to the subject following the first skin treatment procedure, and instructing the subject to conduct a second skin treatment procedure following the first skin treatment procedure, wherein the second skin treatment procedure is performed by the subject, the second skin treatment procedure comprising providing delivering a volume of fluids from the cartridge or other fluid container to a skin surface of the subject. 
     According to some embodiments, the method further comprises a third skin treatment procedure following the second skin treatment procedure, wherein the third skin treatment procedure is performed at a treatment facility. In some embodiments, the subject brings the cartridge or other fluid container to the treatment facility. In some embodiments, the second skin treatment procedure does not comprise exfoliation. In one embodiment, the second skin treatment procedure comprises only fluid delivery to the skin surface of the subject. 
     According to some embodiments, the first skin treatment procedure comprises skin exfoliation, wherein the tip comprises at least one abrasive surface configured to at least partially exfoliate skin when the handpiece is moved relative to the subject&#39;s skin. In some embodiments, the at least one abrasive surface comprises at least one sharp surface along the tip. In some embodiments, the at least one sharp surface comprises a spiral member extending distally from a base surface of the tip. In one embodiment, the at least one sharp surface comprises a post member extending distally from a base surface of the tip. In some arrangements, the cartridge or other fluid container comprises a cap to protect the at least one of a rollerball and a porous member following the first and second skin treatment procedures. 
     According to some embodiments, a skin treatment assembly comprises a handpiece comprising a distal end, the handpiece comprising a recess or cavity configured to receive a cartridge or other fluid container, a tip configured to be positioned along the distal end of the handpiece, the tip being configured to contact a skin surface of a subject during use, and at least one rollerball configured to extend to or near the tip, wherein the rollerball is configured to be in fluid communication with an interior of a cartridge or other fluid container secured to the handpiece, wherein the at least one rollerball is configured to contact the skin surface of the subject during use and to facilitate the delivery of fluids to said skin surface as the rollerball is moved relative to said skin surface. 
     According to some embodiments, the rollerball is secured to a distal end of the cartridge or other fluid container. In one embodiment, the rollerball is secured to the handpiece. In some embodiments, the rollerball is secured to the tip. 
     According to some embodiments, the rollerball is in direct fluid communication with the interior of the cartridge or other fluid container. In some embodiments, the rollerball is in indirect fluid communication with the interior of the cartridge or other fluid container. In one embodiment, the rollerball is in fluid communication with the interior of the cartridge or other fluid container via one or more fluid conduits or passages. 
     According to some embodiments, the assembly further comprising at least one suction conduit extending to the tip, wherein the at least one suction conduit is configured to be placed in fluid communication with a vacuum source to selectively apply suction to the tip during use. In one embodiment, the tip comprises a peripheral lip, wherein the peripheral lip is sized, shaped and configured to contact a subject&#39;s skin tissue and generally form a seal along said skin tissue. 
     According to some embodiments, the assembly further comprises at least one abrasive structure or member located on, near or along the tip, the at least one abrasive structure or member being configured to selectively exfoliate the subject skin during use. In some embodiments, the cartridge or other fluid container is configured to be re-used during a subsequent treatment procedure. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       These and other features, aspects and advantages of the present application are described with reference to drawings of certain embodiments, which are intended to illustrate, but not to limit, the present inventions. It is to be understood that these drawings are for the purpose of illustrating the various concepts disclosed herein and may not be to scale. 
         FIG. 1  illustrates an exploded perspective view an assembly comprising a rollerball for use with a skin treatment system according to one embodiment; 
         FIG. 2  illustrates an exploded perspective view an assembly comprising a rollerball for use with a skin treatment system according to one embodiment; 
         FIG. 3  illustrates an exploded perspective view an assembly comprising a rollerball for use with a skin treatment system according to one embodiment; 
         FIG. 4  illustrates an exploded perspective view an assembly comprising a rollerball for use with a skin treatment system according to one embodiment; 
         FIG. 5  illustrates an exploded perspective view an assembly comprising a rollerball for use with a skin treatment system according to one embodiment; 
         FIG. 6A  illustrates a cross-sectional view of an assembly comprising a rollerball for use with a skin treatment system according to one embodiment; 
         FIG. 6B  illustrates perspective and corresponding exploded perspective views of an assembly comprising a rollerball for use with a skin treatment system according to one embodiment; 
         FIG. 7  illustrates a perspective view of an assembly comprising a rollerball for use with a skin treatment system according to one embodiment; 
         FIG. 8  illustrates a front view of a tip configured to be positioned along a distal end of an assembly disclosed herein, according to one embodiment; 
         FIGS. 9A and 9B  illustrate different views of an assembly comprising a rollerball for use with a skin treatment system according to one embodiment; 
         FIG. 10  illustrates a perspective view of an assembly comprising a wicking member for use with a skin treatment system according to one embodiment; 
         FIG. 11  schematically illustrates a side view of an assembly comprising a wicking member for use with a skin treatment system according to one embodiment; 
         FIG. 12  schematically illustrates a side view of an assembly comprising a wicking member and a rollerball for use with a skin treatment system according to one embodiment; 
         FIG. 13A  schematically illustrates a side view of an embodiment of a tip configured to be positioned along a distal end of a skin treatment assembly; 
         FIGS. 13B to 13D  illustrates different embodiments of the tip of  FIG. 13A  having a wicking or other porous material positioned on and/or along one or more tip portions; 
         FIG. 14  illustrates a perspective view of one embodiment of a skin treatment assembly comprising fluid supply and waste containers attached along the proximal end of the assembly; 
         FIG. 15  schematically illustrates a skin treatment system similar to the system depicted in  FIG. 14 ; 
         FIG. 16  illustrates one embodiment of a system comprising a vacuum source that is in fluid communication with a handpiece or other skin treatment device; 
         FIGS. 17A and 17B  illustrate different exploded views of a system comprising cartridge assembly located between the skin treatment device and a vacuum source according to some embodiments; 
         FIG. 18  illustrates one embodiment of a skin treatment system comprising sensors along or near opposite ends of a vacuum conduit that places a skin treatment member in fluid communication with a vacuum source; 
         FIGS. 19A and 19B  illustrate different perspective views of an assembly comprising a rollerball for use with a skin treatment system according to another embodiment; 
         FIGS. 20A and 20B  illustrate different cross-sectional views of the assembly of  FIGS. 19A and 19B ; 
         FIGS. 21A-21E  illustrate various views of one embodiment of a handpiece assembly comprising a porous member; and 
         FIGS. 22A-22E  illustrate various views of another embodiment of a handpiece assembly comprising a porous member. 
     
    
    
     DETAILED DESCRIPTION 
     Although the various embodiments of a handpiece assembly have specific relevance to a skin treatment system, the features, advantages and other characteristics disclosed herein may have direct or indirect applicability in other applications, such as, for example, medical devices, mechanical devices and/or the like. For instance, the various configurations disclosed herein have specific relevance to exfoliation and/or other removal of the superficial layer of skin cells. However, the various systems, devices and methods disclosed herein can be modified and/or otherwise configured for use with skin treatment procedures that target removal of deeper tissue layers, as desired or required. 
       FIG. 1  illustrates one embodiment of an assembly  100  configured for use with a skin treatment system. As shown, the assembly  100  can include one or more components or portions that are configured to secure to one another. In some embodiments, for example, the assembly  100  comprises a handpiece  110  that is adapted to receive a tip  120  along its distal end. The tip  120  can be revocable from the handpiece  110 , as depicted in  FIG. 1 . However, in other embodiments, the tip  120  can be permanently attached to the handpiece  110  and/or can otherwise be integrated with the handpiece  110 , as desired or required. In some embodiments, the tip  120  can be removable and disposable. The use of such removable tips  120  can facilitate the use of the assembly (e.g., between different subjects) and/or can permit a user to customize a skin treatment procedure. For example, in some embodiments, the tip  120  comprises one or more abrasive features, components and/or portions to help abrade or exfoliate skin as the handpiece is moved relative to skin. For example, in some arrangements, the tip  120  comprises one or more of the following: one or more spiral members, cylinders, posts, gritty surfaces, other abrasive members or features, ridges, sharp edges, diamonds and/or the like. Additional details regarding the tips are included in U.S. patent application Ser. No. 11/392,348, filed on Mar. 29, 2006 and issued as U.S. Pat. No. 8,048,089 on Nov. 1, 2011, the entirety of which is incorporated by reference herein. 
     In other embodiments, however, the tip need not include any abrasive and/or other components or features that are configured to abrade skin. Thus, in some configurations, the tip  120  can simply provide a mechanism or means by which fluids and/or other components are selectively delivered to the skin surface. 
     With continued reference to  FIG. 1 , the handpiece  110  is configured to removably receive a cartridge  140  or other container. For example, the cartridge  140  can be inserted within a corresponding recess of the handpiece  110  (e.g., along the proximal end of the handpiece  110 ). In other arrangements, however, the cartridge  140  or other container can be positioned along any other portion of the handpiece  110 . In other embodiments, the cartridge  140  can be placed in fluid communication or otherwise fluidly coupled to the handpiece  110  and/or the tip  120 . 
     For any of the assembly embodiments disclosed herein, depending on the specific treatment protocol being administered to a subject, a cartridge can comprise one or more of the following: skin tightening agents, platelet-rich plasma (PRP), exfoliation agents, peptides, bleaching agents, anti-acne agents, human growth factors, cytokines, soluble collagen, antioxidants, matrix proteins, Epicatechin, Catechin and/or other phenols and/or other anti-oxidants, neurotoxins, serums, salicylic acid, other anti-acne acids and materials, microcapsules, capsules, other time-release products and substances, water (e.g., distilled, tap water, filtered, etc.), saline, other dilution agents, dilutants or dissolvents, vitamins, chemical exfoliation agents, lotions, soothing agents, brightening or lightening agents, peptides, peeling agents, acids, anesthetics, medicants, other non-active or active compounds, other fluids or materials, combination or mixtures thereof and/or any other substance from one or more internal/external fluid sources. 
     Any of the assembly embodiments disclosed herein comprise at least one rollerball, a wicking, porous and/or other absorptive member and/or other member to facilitate the delivery of one or more fluids and/or other substances from a fluid source (e.g., cartridge, other container, etc.) to the skin surface being treated (e.g., via a distal tip of the assembly). A portion or area of the rollerball or other member can be fluid communication (e.g., directly or indirectly) with the cartridge or other fluid source. In some embodiments, as the assembly is moved relative to a subject&#39;s skin surface, the rollerball and/or other member (e.g., wicking member, other porous or absorptive member, etc.) contacts the skin surface and rolls along the skin surface. In so doing, the rollerball can advantageously deliver fluid from the fluid source (e.g., cartridge, a manifold, etc.) to the tip and working surface along the assembly-skin interface. Accordingly, the rollerball and/or other delivery member can facilitate the delivery of fluids to the skin surface during a treatment procedure as the assembly is moved relative to such a surface. 
     In any of the embodiments disclosed herein, the rollerball can be secured within a housing or other retention assembly (e.g., of the cartridge, handpiece, tip, etc.), allowing it to rotate. The rollerball and/or other member (e.g., absorptive, wicking and/or other member) can be removably (e.g., replaceably) or permanently maintained within a retention assembly or other portion of the assembly, as desired or required. For example, the rollerball can be removed and replaced (e.g., to change its materials or other properties, to change it smoothness, texture or porosity, to change its size, to replace a damaged or used rollerball, etc.). However, in other configurations, the rollerball or other member is configured to not be removed from the corresponding housing or retention assembly. 
     In  FIG. 1 , the handpiece  110  of the assembly  100  comprises a central opening  112  along its distal end  111 . The opening  112  can be sized, shaped and otherwise configured to at least partially receive the rollerball  144  located along the distal end  142  of the cartridge  140 . Thus, in some embodiments, the cartridge is configured to releasably engage the handpiece. The cartridge  140  and handpiece can be releasably secured to one another using one or more attachment features, devices and/or methods, such as, for example, a threaded connection, a friction fit or pressure fit connection, a flanged connection, a rotatable connection (e.g., comprising a recess and a corresponding tab), other mechanical or non-mechanical connections and/or the like. Regardless of the exact attachment or securement mechanism between the handpiece and the cartridge, once the cartridge has been adequately positioned relative to the handpiece, the rollerball  144  can be configured to extend at least partially along the distal end of the handpiece  110 . In some arrangements, the cartridge or other container  140  comprises a dummy cartridge that is configured to be placed in fluid communication with a fluid delivery system (e.g., a manifold-based system). Thus, in such configurations, fluid from one or more fluid sources can be selectively delivered to the cartridge  140  and to the distal end (e.g., tip  120 ) using one or more fluid conduits, as desired or required. 
     With continued reference to  FIG. 1 , the distal tip  120  can be configured to be removably secured to the handpiece  110  (e.g., along the distal end  111  of the handpiece  110  and the proximal end  123  of the tip  120 . As with any other connections between adjacent components or portions of the assembly  100 , one or more O-rings  113  or other sealing members can be positioned along the interface of the tip  120  and the handpiece  110  (e.g., to prevent or reduce the likelihood of leaks), in accordance with a desired or required arrangement. 
     As depicted in  FIG. 1 , the tip  120  can include a central opening  122  along its distal end that coincides with (e.g., shares the same longitudinal axis as) the rollerball  144  and the opening  112  of the handpiece  110 . Thus, when the assembly  100  is properly assembled or otherwise put together, the rollerball  144  can be adjacent the area defined by the central opening  122  of the tip  120 . In some embodiments, the tip comprises a peripheral lip  124  that circumscribes a central area (e.g., an area at least partially defined by the central opening  122  of the tip  120 ). Further, the rollerball  144  can be sized, shaped and otherwise configured to be positioned within the central area circumscribed by the lip  124  of the tip  120 . In some arrangements, the distal end of the rollerball  144  is recessed relative to the distal end of the tip&#39;s lip  124 . However, in other configurations, the distal end of the rollerball  144  can be aligned with or generally aligned with the distal end of the lip  124  of the tip  120 , as desired or required. 
     According to some embodiments, as discussed in greater detail herein, the assembly  100  is configured to be selectively coupled to a vacuum or suction source. Thus, the tip, handpiece, cartridge or other fluid source and/or any other portion of the assembly  100  can include one or more fluid passages, openings, ports, valves and/or any other features to enable the vacuum or suction capabilities of the assembly  100 . For example, the tip can include one or more suction ports that are aligned with one or more fluid conduits (e.g., internal and/or external passages) of the handpiece  110 . As discussed in greater detail herein, any of the disclosed embodiments can include one or more features (e.g., peripheral lip, interior feature such as posts or cylindrical members, spiral members, abrasive pad or members, and/or the like) that are configured to selectively abrade tissue. For example, in any of the embodiments, the peripheral lip  124  can be configured to at least partially abrade and/or otherwise remove skin tissue when the handpiece assembly is moved relative to the skin surface. 
     Regardless of the exact fluid components that an assembly  100  comprises to enable it to selectively deliver a vacuum or suction force to the tip  120 , the selective activation of such suction or vacuum can facilitate a skin treatment procedure and/or the use of the assembly. For example, in some embodiments, the use of suction can help with the delivery of fluids from a fluid source to the tip. In some embodiments, the use of vacuum can help create a seal between a periphery (e.g., lip) of the tip and the skin tissue, which in turn, can help with the delivery of fluids to the skin interface. As noted above, the use of a lip and/or any other interior members can assist with the at least partial abrading of tissue when the handpiece assembly is moved relative to a skin surface (e.g., especially when vacuum is being applied to the tip). 
     As illustrated in  FIG. 1 , in some embodiments, the cartridge, container or other fluid source  140  can be configured to be re-used over a period of time. For example, the distal end  142  of the cartridge  140  can be protected between uses by a cap or other sealing member  150 . Thus, the rollerball  144  of the cartridge  140  can be protected when not in use. The cartridge  140  can be re-used between various treatment procedures by a professional. In some embodiments, the cartridge  140  can be provided to the subject for application of fluid at home between visits to a professional. 
     In any of the embodiments disclosed herein or variations thereof, the tip and/or the entire handpiece assembly (e.g., especially in arrangements where the tip is not removable from the rest of the handpiece assembly) can be disposable. Thus, the tip can be configured for a single use prior to disposal. Accordingly, the tip can include one or more thermoplastic and/or other materials that are well suited for a single use application. Alternatively, the tip and/or other components of the assembly can include one or more metals, alloys, other rigid and/or semi-rigid materials and/or other materials that enable a user to re-use such items, as desired or required. For example, metallic and/or alloy-based tips (e.g., comprising stainless steel, titanium, platinum, etc.) can be configured to be autoclaved and/or otherwise sterilized between uses. 
       FIG. 1  illustrates the device being capped along its distal end using a cap or other enclosure  150 . As shown, such a cap or other enclosure  150  can help isolate the rollerball and/or other distal member (e.g., wicking member, absorptive member, etc.) from the surrounding environment. This can be helpful when the handpiece assembly  100  is not in use to ensure that contaminants and/or other substances do not taint the rollerball, another member that facilitates delivery of fluids and/or other materials to the tip and/or other portion of the distal end of the assembly  100  that may contact a targeted skin surface. 
       FIG. 2  illustrates a different embodiment of an assembly  200  configured for skin treatment. The assembly  200  is similar to the one depicted in  FIG. 1  and described above; however, the rollerball  214  in the assembly  200  of  FIG. 2  is positioned along the distal end  212  of the handpiece  210 , instead of the cartridge  240 . As with other embodiments disclosed and illustrated herein, the handpiece can be configured to receive a tip  220  along the distal end  212  of the handpiece  210 . The distal end  212  of the handpiece  210  with the rollerball  214  can be configured to pass through the interior of the tip  220  and extend toward a central opening  222  of the tip. Thus, as the assembly  200  is moved relative to a skin surface, the rollerball  214  can at least partially engage the skin surface, and with movement along such skin surface, can help deliver fluids from a cartridge or other fluid source  240  to the subject&#39;s skin. As discussed above with reference to the embodiment illustrated in  FIG. 1 , the delivery of fluids to the skin surface can be facilitated, in certain configurations, with the application of suction or vacuum. In addition, the cartridge, container or other fluid source  240  can include a cap or other enclosure member  250  that is configured to be secured to the distal end of the cartridge  240 . Although in the depicted arrangement the cartridge  240  does not include a rollerball along its distal end, the cap  250  can ensure that the contents of the cartridge and/or other portions of the cartridge  240  that may be exposed to contamination are kept clean and are otherwise protected between uses. 
     Further, as noted above, the tip  220  can include one or more abrasive features, surfaces and/or the like such that when the tip is moved relative to a targeted skin surface (e.g., especially upon activation of a vacuum source that draws the tip toward and/or engaged with the targeted skin surface), at least portions of the targeted skin surface can be selectively abraded or otherwise removed. For example, in some arrangements, the peripheral lip of the tip  220  can be configured to at least partially abrade or otherwise remove skin tissue when the assembly  200  is moved relative to a subject&#39;s skin surface. Such abrasive features or designs can be incorporated into any embodiments disclosed herein or variations thereof. 
       FIG. 3  illustrates an exploded perspective view of yet another embodiment of an assembly  300  that can be used to perform a skin treatment procedure. As shown, and similar to other configurations depicted herein, the assembly  300  can comprise a cartridge  340 , a handpiece  310  that is sized, shaped and otherwise configured to receive a cartridge and a distal tip  320 . The various components of the assembly  300  can be configured to removably secure to each other. However, in other embodiments, the two or more of the components can be permanently or semi-permanently secured to each other (e.g., so as to form a monolithic or unitary structure). Such a configuration, wherein two or more portions form a unitary or monolithic structure, can be incorporated into any of the embodiments disclosed herein or variations thereof. 
     With continued reference to  FIG. 3 , unlike the configurations depicted in  FIGS. 1 and 2 , the rollerball and/or other member (e.g., absorptive member, wicking member, porous member, etc.)  324  is positioned along the tip  320 . Thus, in some embodiments, the rollerball  324  is configured to be in fluid communication, directly or indirectly, with an internal reservoir or other fluid-containing portion of the cartridge, container or other fluid source  340 . For example, in some arrangements, the rollerball  324  of the tip  320  is configured to receive fluid from the cartridge  320  via one or more passages, channels or other intermediate fluid reservoirs or members that extend at least partially from the cartridge  340  to the tip  320 . As with other embodiments disclosed herein, the cartridge  340  can be re-used in different treatment procedures. For example, the subject can be provided with any unused cartridges  340  following a visit to a professional. Thus, depending on the particular skin treatment protocol being used, the subject can simply bring one or more unused cartridges  340  to the next scheduled treatment procedure and/or can be apply certain fluids to his or her skin between visits, as desired or required by a particular treatment protocol. 
       FIG. 4  illustrates an exploded perspective view of an assembly  400  that is a variation of the arrangement depicted in  FIG. 1 . As in  FIG. 1 , the depicted assembly  400  comprises a cartridge  440  having a rollerball  444  along its distal end. The cartridge, container or other fluid source  440  is sized, shaped and otherwise configured to be inserted and secured, at least partially, within a corresponding recess or opening along the proximal end of a handpiece  410 . As with the embodiment of  FIG. 1 , the rollerball  444  along the distal end of the cartridge, container or other fluid source  440  can extend to, near and/or past the distal opening  412  of the handpiece  410 . Accordingly, as the assembly  400  is moved relative to a skin surface of a subject, the rollerball  444  can at least partially contact the skin surface and rotate, thereby drawing out fluid, either directly or indirectly, from the cartridge or other fluid source  440 . In some embodiments, as discussed herein, contact between the rollerball  444  and the skin surface and/or the drawing of liquid toward the skin surface is facilitated by the activation of a vacuum or suction force along the tip  420 . For example, a peripheral lip  424  of the tip  420  can extend outwardly so as to contact skin tissue and circumscribe an interior region of the tip during use. The lip  424  can, therefore, be used to create a complete or partial seal with the skin surface being treated during use. Accordingly, in such configurations, once a vacuum or suction force is activated, skin located within an interior of the peripheral lip  424  of the tip  420  can be at least partially drawn into toward the assembly to facilitate and/or enhance contact between the rollerball  444  and the skin surface. Also, as noted herein, such embodiments that utilize suction can help deliver or enhance the delivery of fluids from the cartridge or other fluid source  440  to the tip. Further, as discussed in greater detail herein, the peripheral lip  424  and/or any other member (e.g., one or more interior members or portion of the tip, such as, posts, other cylindrical members, spiral members, abrasive pads and/or the like) can be used to at least partially abrade skin tissue as the tip is moved relative to a targeted skin surface. 
     As illustrated in  FIG. 4  and discussed in greater detail herein, the tip can include one or more abrasive members or features  422 . For example, such abrasive members or features  422  can comprise one or more sharp edges or surfaces, spiral members, posts, grit or other roughened members or surfaces and/or the like. As noted above, for any of the embodiments disclosed herein or variations thereof, the peripheral lip can be shaped and otherwise configured to abrade tissue. Additional details regarding the various abrasive members or features that can be incorporated into the tip to help exfoliate a subject skin are provided in U.S. patent application Ser. No. 11/392,348, filed on Mar. 29, 2006 and issued as U.S. Pat. No. 8,048,089 on Nov. 1, 2011, the entirety of which is incorporated by reference herein. 
     Further, in any of the embodiments disclosed herein or variations thereof, one or more materials can be positioned on, which, along and/or near the tip. In some arrangements, such materials are positioned along a cavity or similar retention member (e.g., an interior of a post or other interior member, another cavity or member along or near the tip, etc.), as desired or required. Such materials can be configured to at least partially dissolve or otherwise be released in the presence of water, other liquid or fluid and/or another diluting agent. In some embodiments, such materials are stored in porous or absorptive members and are configured to at least partially release from such members in the presence of a liquid. Accordingly, in such configurations, the various serums and/or other treatment materials that are desired to be delivered to a subject&#39;s skin surface for a particular treatment protocol can be embedded or otherwise located along or near the tip. Water, saline and/or another diluting agent can be advantageously delivered to the tip to selectively dilute and release the serums and/or other treatment materials to the subject skin. Additional details regarding positioning dissolvable or otherwise releasable materials on or near the tip of an assembly are provided in U.S. patent application Ser. No. 11/392,348, filed on Mar. 29, 2006, and issued as U.S. Pat. No. 8,048,089 on Nov. 1, 2011, and U.S. patent application Ser. No. 12/832,663, filed on Jul. 8, 2010 and issued as U.S. Pat. No. 8,814,836 on Aug. 26, 2014, the entireties of both of which are hereby incorporated by reference herein. 
     Another variation of an assembly  500  that comprises a rollerball  524  to facilitate the delivery of fluids to a skin surface is illustrated in  FIG. 5 . As shown, the assembly  500  comprises a cartridge or other fluid source  540  that is configured to be positioned within a corresponding recess or area along the proximal end of a handpiece  510 . In addition, as discussed herein with reference to other embodiments, a removable tip  520  can be configured to be secured to the distal end of the handpiece  510 . In the depicted embodiment, the tip  520  comprises both a rollerball  524  and an abrasive surface or structure  522 . Thus, in such a configuration, moving the assembly  500  relative to a skin surface of a subject can assist with the delivery of fluids to the skin surface, while causing skin tissue to be abraded or exfoliated. 
     A side cross-sectional side view of another embodiment of a skin treatment assembly  600  comprising a rollerball  624  is illustrated in  FIG. 6A . As shown, the cartridge or other fluid source  640  can be sized, shaped and otherwise configured to be positioned within a recess or other opening of the handpiece  610 . In the illustrated embodiment, the rollerball  624  is positioned along a distal end of the cartridge  640 . However, in other configurations, as discussed herein with reference to  FIGS. 2, 3 and 5 , the rollerball can be positioned on the handpiece or the tip, as desired or required. 
     With continued reference to  FIG. 6A , the cartridge  640  can include a tapered portion  648  along its distal end. Such a tapered portion can include two or more vanes, baffles and/or other separation members  646  that increase the surface area of the fluid channel or conduit of the cartridge  640  along the end of the cartridge near the rollerball  624 . The vanes or baffles  646  can help maintain liquid contained within the cartridge  640  near the distal end of the cartridge  640 . For example, such features can help retain liquids therein as a result of the surface tension of the liquid. Accordingly, in some embodiments, at least a volume of liquid can be maintained at or near the distal end of the cartridge  640 , and thus the rollerball  624 . In some arrangements, therefore, a minimum volume of liquid and/or other material contained within the cartridge  640  can be positioned adjacent the rollerball  624  to permit such liquid and/or other material to be selectively delivered to the skin when the assembly  600  is moved relative to the subject&#39;s skin surface. In some embodiments, for example, at least some volume of liquid can be disposed at or near the distal end of the cartridge regardless of the exact orientation of the assembly (e.g., when gravity tends to move the liquid away from the distal end of the cartridge). 
     As illustrated in  FIG. 6A , the cartridge  640  can be sized, shaped and configured to extend past the distal end of the handpiece  610 . In some embodiments, the distal end of the cartridge  640  can extend partially or completely within and/or through a tip  620  that is secured to the distal end of the handpiece  610 . In the illustrated embodiment, the rollerball  624  extends past the distal end of the tip  624 . However, in other arrangements, the rollerball  624  is flush (or generally flush) with or recessed relative to the distal end of the tip  624 . 
     Further, as shown in  FIG. 6A , the tip  624  can comprise one or more vacuum or suction ports and passages  628  that place the distal end of the tip  624 , and thus, the assembly  600 , in fluid communication with a vacuum source (not shown). The tip  624  can include one, two or more suction ports and/or passages  628 , as desired or required. The quantity, size, shape, orientation and/or other details about any suction ports/passages  628  included on a tip can vary, depending on the particular design. As depicted in the cross-sectional view of  FIG. 6A , the suction ports and passages  628  can be configured to be fluid communication with one or more vacuum or suction conduits or passages V of the handpiece  610 . The vacuum or suction conduit(s) V can be positioned within an interior portion of the handpiece  610 , as illustrated in  FIG. 6A . However, in other embodiments, the vacuum or suction conduit(s) can be located along an exterior of the handpiece  610  and/or any other portion of the assembly  600 , as desired or required. 
     Regardless of the exact properties and details of the various components of an assembly&#39;s vacuum or suction system (including, e.g., the suction ports and/or passages  628 , the suction conduit V and/or the like), once activated, the vacuum or suction system can be configured to generate, either intermittently or continuously, a vacuum force along the distal end of the tip  628 . In some embodiments, such a vacuum force can help draw skin toward the tip  628 , can facilitate with the delivery of fluids from the cartridge or other container  640  toward the skin and/or provide other benefits. 
     Another embodiment of an assembly  600 B is illustrated in  FIG. 6B . As shown, and similar to the embodiment of  FIG. 6A , the depicted assembly  600 B comprises a handpiece  610 B that is configured to receive a tip  620 B along its distal end. In some embodiments, the tip  620 B can be removable from the handpiece  610 B. However, the tip can be permanently or semi-permanently attached to the handpiece  610 B (or can form a unitary or monolithic structure with the handpiece  610 B). Further, as with other embodiments disclosed herein, a cartridge or other fluid source  640 B can be configured to be secured within a portion (e.g., recess, cavity, etc.) of the handpiece  610 B. 
     With continued reference to  FIG. 6B , the distal end of the cartridge  640 B can comprise one or more rollerballs  644 B. In some embodiments, once properly secured to (e.g., within) the handpiece  610 B, the distal end of the cartridge  640 B and the rollerball  644 B positioned on or near the distal end will extend to, near and/or through a central opening  612 B along the distal end of the handpiece  610 B. Likewise, the tip  620 B can comprise an opening to permit the rollerball  644 B to at least partially contact a subject&#39;s skin surface when the assembly  600 B is moved relative to such a skin surface during use. For example, the tip  620 B can include a central opening that is aligned with the rollerball  644 B and provides direct access between the rollerball  644 B and the distal end of the tip. Thus, as with other assembly arrangements disclosed herein, once the assembly  600 B is moved along a subject&#39;s skin, the rollerball  644 B can rotate to facilitate the delivery of fluids and/or other materials from the cartridge  640 B to the tip  620 B. For example, the rollerball  644 B can be in fluid communication with one or more interior portions of the cartridge  640 B. 
     According to some embodiments, the assembly  600 B can be configured for the delivery of a vacuum or suction force along the tip  620 B. As shown in  FIG. 6B , the handpiece  610 B can comprise a suction conduit  619 B that extends from the exterior surface of the handpiece  610 B and is configured to be placed in fluid communication with a vacuum source V (not shown). In some embodiments, however, as discussed herein with reference to  FIG. 6A , for example, the suction or vacuum conduit or other hydraulic components can be routed through an interior of the handpiece  610 B or other portion of the assembly  600 B. For any of the embodiments disclosed herein or variations thereof, however, an assembly may not be configured for placement in fluid communication with a vacuum or suction source. 
       FIG. 7  illustrates another embodiment of a skin treatment assembly  700  comprising a rollerball to facilitate the delivery of fluids from a cartridge or other reservoir  740  to the tip  720  when the assembly  700  is moved relative to a subject skin surface. As shown, the assembly  700  can include a waste container or compartment  760  that is configured to receive any spent fluids and/or debris (e.g., exfoliated skin) that are removed from the tip  720 . For example, in some embodiments, the waste container  760  can be in fluid communication with a vacuum or suction source to assist in drawing waste (e.g., spent fluids, exfoliated skin, other debris, etc.) away from the tip and the skin surface during a treatment procedure. Thus, as discussed with respect to other embodiments illustrated and described herein, one or more suction ports, passages, conduits, valves and/or other hydraulic components can be positioned between the tip and the waste container  760 . In the arrangement illustrated in  FIG. 7 , the waste compartment is incorporated (e.g., removably) within the assembly  700 . However, in other embodiments that include a suction or vacuum system, the waste can be delivered to a container, compartment or other collection point that is not incorporated within the assembly. For example, one or more vacuum conduits (e.g., tubing) can be used to deliver waste materials (e.g., exfoliated skin, spent fluids, etc.) to a separate container. 
       FIG. 8  illustrates a front view of a tip  820  that is configured for use with one or more of the skin treatment assemblies disclosed herein or variations thereof. As with other arrangements illustrated and described herein, the tip  820  can include one or more rollerballs  824  that are configured to facilitate the delivery of fluids from a fluid source (e.g., a cartridge) to the tip and skin surface of the subject being treated when the assembly is moved relative to the subject&#39;s skin during use. 
     With continued reference to  FIG. 8 , the tip  820  can include a peripheral lip  822  that defines an interior region. In some embodiments, the lip  822  is sized, shaped and otherwise configured to contact the skin surface during use (e.g., whereas an interior region of the tip defined by the lip  822  is generally recessed relative to the distal end of the lip). As shown, the tip  820  can include one or more posts, other interior members and/or other abrading members or structures  826  (e.g., ridges, spiral-shaped members, other sharp surfaces, gritty or abrasive members, etc.) to help in the exfoliation of skin tissue as the tip is moved relative to a subject&#39;s skin. In some embodiments, however, the peripheral lip  822  can be configured to exfoliate skin tissue as the assembly is moved relative to a subject&#39;s skin surface during use, either in addition to or in lieu of any abrasive structures or members  826  positioned along an interior region of the tip  820 . 
     With continued reference to  FIG. 8 , the tip can include one or more vacuum or suction ports  828   a ,  828   b  through which waste materials (e.g., spent fluids, exfoliated skin, other debris, etc.) can pass when the assembly&#39;s suction system is activated. The quantity, size, shape, spacing, orientation and/or other properties of the vacuum or suction ports  828   a ,  828   b  can be different than illustrated in  FIG. 8 , as desired or required by a particular design or application. 
     Further, as discussed in greater detail herein, the clearance or spacing between the rollerball  824  and the adjacent base surface  827  of the tip  820  can vary. For example, in some embodiments, such a clearance is about 1/128 th  to ½ inch. The rollerball  824  can be located within a housing that permits the rollerball to freely rotate and prevent the rollerball from being separated or otherwise removed from the tip during use. As noted herein, in some embodiments, the rollerball can be selectively removable from a particular housing of the tip, handpiece and/or cartridge (depending on which component of an assembly the rollerball is secured) for replacement, cleaning, maintenance and/or the like. 
     In any of the embodiments, disclosed herein, an assembly can include one, two or more rollerballs to facilitate the delivery or transfer of fluid from a cartridge, reservoir or other fluid source to the tip and the skin surface of a subject. The rollerball can be positioned along the longitudinal centerline of the assembly; however, in some arrangements, the rollerball is offset from the longitudinal centerline, as desired or required. Further, the rollerball can include one or more materials, such as, for example, metals or alloys (e.g., stainless steel, brass, titanium, etc.), thermoplastics and/or any other synthetic or natural material. The diameter (or other cross-sectional dimension) of the rollerball can be approximately ¼ inch to 2 inches. However, in other embodiments, the diameter or other cross-sectional dimension of the rollerball, wicking member and/or other member positioned along the distal end of a handpiece can be smaller than ¼ inches or greater than 2 inches, as desired or required. 
     According to some embodiments, the rollerball can include a solid (e.g., non-porous) structure or a porous structure, as desired or required. In any of the embodiments disclosed herein, the rollerball can include one or more coatings or other materials. For example, the rollerball can include one or more layers of dissolvable materials that are configured to dissolve and thus be released to the skin surface being treated in the presence of water or another diluting agent. In some arrangements, a rollerball comprises a porous structure that is at least partially saturated with one or more substances that are configured to be released (e.g., dissolve) during use. Such materials can be located, at least initially, within an interior portion of the rollerball. As discussed herein, the rollerball can be included in a system that is configured to generate a vacuum or suction at or near the tip, thereby enhancing the effect of using a rollerball or similar structure to engage targeted skin and/or delivery fluids to the skin surface. Further, the rollerball can be positioned adjacent a wicking member, porous member and/or other member that is configured to retain liquid. This can assist in ensuring that the rollerball maintains a certain degree of moisture, regardless of whether liquid would be otherwise immediately present at or near the rollerball. 
     In any of the embodiments disclosed herein, the rollerball and/or wicking member can comprise one or more abrasive and/or other roughened or sharp surfaces or features. Such embodiments can facilitate exfoliation of skin as the handpiece is moved along a subject&#39;s skin surface. 
     Another embodiment of a skin treatment assembly  900  comprising a rollerball is illustrated in  FIGS. 9A and 9B . Unlike other arrangements disclosed herein, the depicted assembly  900  includes a handpiece and a tip that are integrated into a single unitary or monolithic structure  910 . In some embodiments, such a combined handpiece and tip can be configured to be disposable so it is replaced between uses. According to some embodiments, the assembly  900  comprises a cartridge or other fluid source  940  that is configured to secure to the combination handpiece/tip  910 . 
     With continued reference to  FIG. 9B , the distal end  942  of the cartridge  940  can include a rollerball  944  that is routed through an interior portion of the combination handpiece/tip  910  when the cartridge  940  is positioned therein. In some embodiments, the rollerball  944  extends to or near the distal end of the combination handpiece/tip  910  when the assembly  900  is ready for use. Accordingly, as the assembly  900  is moved relative to a subject&#39;s skin surface, the rollerball can at least partially contact the skin surface being treated and rotate. Rotation of the rollerball  944  can facilitate the transfer of fluid and/or other contents of the cartridge  940  to the distal end of the combination handpiece/tip  910 , and thus, the skin surface. 
     As shown in  FIGS. 9A and 9B , the proximal end  945  of the cartridge  940  can include a closure member  946  that sealingly encloses an interior of the cartridge  940 . Thus, in some embodiments, the interior of the cartridge  940  can be opened, refilled and closed. However, in other arrangements, the cartridge  940  is configured to remain sealed at all times. Thus, is such configurations, the cartridges are disposable after use. The above disclosure regarding cartridges that can be opened and cartridges that are configured to remain sealed can be applied to any of the assembly arrangements disclosed herein or variations thereof. 
     As discussed above with reference to other embodiments, the cartridge  940  included in the assembly  900  of  FIGS. 9A and 9B  can be re-used between sequential treatment procedures. For example, once the subject has completed a particular treatment session, the subject can be permitted to take home any used cartridge or cartridges (to the extent two or more different serums or other treatment materials were used). Thus, the subject can bring the unused cartridges to a subsequent treatment session, thereby eliminating waste and reducing the overall expense of a procedure. In some embodiments, the subject can be instructed to apply one or more of the serums and/or other materials contained within the corresponding unused cartridges  940  to his or her skin between office visits. Accordingly, in order to prevent contamination of the cartridges and their internal contents, to prevent evaporation, leaks or other loss of the internal contents of the cartridges, to otherwise protect the cartridges (e.g., the rollerball  944  located along the cartridge&#39;s distal end) and/or to provide one or more additional benefits or advantages, a cap  950  can be used to protect the distal end  942  of a cartridge between uses. The rollerball  944  can facilitate the application of fluid to the subject&#39;s skin surface between office visits. For example, the use of a rollerball can advantageously permit fluid to be delivered from the interior of the cartridge  940  to the subject&#39;s skin surface without the use of suction or a handpiece. Thus, the overall effectiveness of a skin treatment procedure can be advantageously enhanced by such embodiments. 
     In some embodiments related to the treatment of acne, for example, two main serums or materials can be used during a treatment procedure. Thus, during a first visit to a professional, the subject undergoes a two-step treatment procedure in which an acidic formulation (e.g., salicylic acid) is first applied to the subject&#39;s skin surface (e.g., with or without the application of vacuum) to remove impurities and clear out the subject&#39;s pores. As a follow-up step, an antibiotic or other treatment serum is applied to the skin. In some embodiments, as discussed herein, the user is then provided with cartridges or other fluid containers. Such cartridges can be advantageously returned to the professional for conducting a follow-up procedure during a subsequent visit. In addition, the subject can be instructed, in accordance with certain protocols, to periodically apply one or more of these serums or fluids to his or her skin between visits, as desired or required. 
     As noted above, the combination handpiece/tip  910  included in the assembly of  FIGS. 9A and 9B  can be disposable between uses or sequential procedures. Thus, the use of such a disposable portion can reduce the likelihood of the transfer of contamination between subjects and/or procedures, thereby improving the overall hygiene and safety of skin treatment procedures. 
     With continued reference to  FIGS. 9A and 9B , the combination handpiece/tip  910  can include a suction port or conduit  918  that is configured to be placed in fluid communication with a vacuum source. In the illustrated embodiment, suction port  918  extends along an exterior of the handpiece/tip component  910  (e.g., at an angle); however, in other arrangements, the suction port or conduit  918  can extend, at least partially or completely, within an interior of the assembly  900 , as desired or required. In yet other embodiments, the assembly  900  is not configured to be placed in fluid communication with a suction or vacuum source. Accordingly, in such arrangements, the assembly need not have any suction or vacuum ports, passages, conduits and/or other related components or features. 
     In any of the embodiments disclosed herein, including those illustrated in  FIGS. 1-9B , the rollerball or similar feature along the distal end of a cartridge, handpiece and/or tip can be replaced with one or more other features that to help to selectively deliver fluid to the skin surface being treated (e.g., from a reservoir of a cartridge or other container placed in fluid communication with the system). For example, as illustrated in the embodiment of  FIG. 10 , the rollerball can be replaced with a wicking or other fluidly porous member  1044  along its distal end. 
     With reference to  FIG. 10 , the distal end  1042  of the cartridge  1040  can include a wicking member or other porous member  1044 . In some embodiments, the rollerball  944  extends to or near the distal end of the combination handpiece/tip when the assembly is ready for use. Accordingly, as the assembly is moved relative to a subject&#39;s skin surface, the wicking member  1044  can at least partially contact the skin surface being treated and deliver fluid from the fluid reservoir of the cartridge or other container  1040  to the skin surface. The wicking member  1044  can comprise one or more porous materials or features, such as, for example, foam, a porous stone, sponge or other member, another material or member comprising a porous or otherwise open or semi-open structure. In some embodiments, the wicking or other porous member  1044  can be saturated with the particular fluids contained within the reservoir of the cartridge or other container member. Thus, the wicking member  1044  can retain the necessary moisture level to selectively deliver fluid to the skin surface treated, even when the level of fluid within the cartridge or the other container  1040  is relatively low. 
     With continued reference to  FIG. 10 , the wicking member  1044  can comprise one or more foams, thermoplastics and/or other materials. The cross-sectional size of the wicking member can be between ¼ inch and 2 inches. In some embodiments, the wicking member  1044  extends, at least partially, within the interior reservoir of the cartridge or other container. The wicking member  1044  can include any cross-sectional shape, as desired or required, such as, for example, circular, oval, square or other rectangular, other polygonal (e.g., triangular, pentagonal, hexagonal, octagonal, decagonal, etc.), irregular. 
       FIG. 11  schematically illustrates a skin treatment system  1000  similar to the system depicted in  FIG. 10 . As shown, the system  1000  can include a cartridge or other container  1040  comprising a wicking or other porous structure  1044  along its distal end. The wicking or other porous structure can include one or more materials that are configured to at least partially absorb, adsorb and/or otherwise retain a volume of liquid or other material. As discussed herein, according to some embodiments, such a wicking structure  1044  can be used to keep the distal end of the cartridge  1040  at least partially moist for purposes of delivering fluids and/or other materials to the skin surface of a subject during a particular procedure. 
     According to some embodiments, the wicking or other porous structure  1044  incorporated into any of the embodiments herein (e.g., the distal end of a cartridge or other container, the handpiece, the tip, etc.) can be used for one or more purposes. For example, in some embodiments, the wicking material can be used to perform one or more of the following functions: (i) to store one or more materials within a portion of a skin treatment assembly (e.g., along a distal end of a cartridge, along a tip of an assembly, along a handpiece, etc.); (ii) as a filter (e.g., for waste debris leaving the skin surface being treated); (iii) for delivering fluids and/or other materials to the skin surface being treated; and/or the like. For example, in one embodiment, a wicking or other porous material  1044  can include a treatment material (e.g., as a liquid, gel, powder, etc.). Water or another dilution agent can then be delivered to or near the wicking or porous member  1040  to selectively release the materials stored within the wicking or other porous member. 
     According to some embodiments, as schematically illustrated in  FIG. 12 , a rollerball or other movable member  1146  can be positioned along the distal end of a wicking or other porous member or structure  1144 . In such a system  1100 , the wicking member  1144  and rollerball  1146  can be positioned along the distal end of a cartridge  1140 . Alternatively, as with other configurations disclosed herein, the wicking member  1144  and/or the rollerball  1146  (or combination thereof) can be located along the handpiece, the tip and/or any other location of the skin treatment assembly. In such embodiments, the rollerball  1146  can be kept in fluid communication with the fluid contained within the cartridge or other container with the assistance of the wicking member or structure. In other words, the proximal end of the rollerball can be advantageously maintained moist with the assistance of the wicking material. Thus, for example, if the handpiece is being handled such that the liquid would be away from the rollerball  1146 , the wicking or porous member helps to ensure that a certain degree of liquidity or moisture is maintained adjacent the rollerball or other movable member. This can help promote a more consistent application of liquid to the skin surface. 
       FIG. 13A  illustrates schematically a tip  1200  that is configured to be positioned along the distal end of a skin treatment system. As shown and discussed in greater detail in one or more applications incorporated by reference herein, the tip  1200  can include a peripheral lip  1222  that is configured to contact skin tissue and form a seal during use (e.g., to help deliver fluids to the skin surface upon the application of vacuum or suction to the assembly). With continued reference to  FIG. 13A , the tip  1200  can also include a recessed base  1224  from which one or more abrading members or structures  1226  extend. For example, such abrading members or structures can include one or more posts, spiral ridges and/or the like. Regardless of their exact shape, structure and/or other properties, such abrading members or structures  1226  can include a sharp or abrading edge or structure to facilitating the abrasion of skin tissue during use. 
     As shown schematically in  FIGS. 13B to 13D , one or more wicking or porous structures or members  1250  can be advantageously positioned along, near or within a portion of the tip  1200 . Such wicking or porous members  1250 A,  1250 B,  1250 C can include within their structures one or more materials that are intended to be released to the skin surface during use (e.g., when a dilution agent is delivered to the tip). For example, as shown in  FIG. 13B , the wicking or porous member  1250 A can be positioned along one or more posts or other protruding members  1226  of the tip. In other embodiments, as shown in  FIG. 13C , the wicking or porous member can be positioned along the underside of the base  1224 , but can still be in fluid communication with a dilution agent (e.g., water) that is selectively delivered to the tip. In such arrangements, the wicking member  1250 B can comprise a disk or other component that fits within or other portion of the tip (e.g. friction fit, using one or other fasteners or other retaining members, etc.). In yet other embodiments, as shown in  FIG. 13D , the wicking member  1250 C can be positioned along one or more recesses of the base  1224  and/or other portion of the tip  1200 . 
       FIG. 14  illustrates a perspective view of a skin treatment assembly  1300  that comprises a unitary structure  1340  along its proximal end that is configured to releasably secure to a proximal handpiece portion  1310 . In some embodiments, such a unitary structure  1340  comprises one or more compartments or portions. For example, one compartment or portion of the structure  1340  can be used to store a fluid or other treatment material that is intended to be selectively delivered to a skin surface via the handpiece  1310  and the distal tip  1320 . Further in some embodiments, the structure  1340  can include one or more additional compartments or portion. In one embodiment, for instance, such an additional compartment can include a waste compartment that is configured to receive spend fluids, abraded skin and/or other debris removed from the skin surface being treated. Additional details regarding such assemblies are provided in U.S. Pat. No. 8,343,116, filed as U.S. patent application Ser. No. 12/346,582 on Dec. 30, 2008 and issued on Jan. 1, 2013. 
       FIG. 15  schematically illustrates one embodiment of an assembly similar to the one discussed herein with reference to  FIG. 14 . As shown, in some embodiments, a wicking materials or other porous structure  1349  can be positioned along the interior of the waste compartment  1346  of a unitary structure  1340 . The wicking or other porous structure can help absorb the waste materials within its structure to facilitate the use of a handheld device, especially one (like in  FIG. 14 ) that incorporates a waste structure at its proximal end. In other words, the wicking material  1349  can help ensure that the waste fluids and/or other waste materials do not disadvantageously move within the compartment  1346  during use. In addition, such a configuration can assist with the removal and/or disposal of the waste contents from the waste compartment. For example, in some embodiments, the wicking and/or other porous member can be easily removed and discarded without having to deal with loose fluids. 
     In some embodiments, as illustrated schematically in  FIG. 15 , a hydrophobic member  1343 ,  1347  can be advantageously placed along a portion of the fluid retention compartment  1342  and/or the waste compartment  1346  to facilitate the passage of air into and/or out of the compartments  1342 ,  1346  during use. For example, such members  1343 ,  1347  can act as one way valves that permit air to pass therethrough (e.g., to prevent or reduce the likelihood of vacuum forces from forming within the respective compartments), while not allowing liquids and/or other materials from passing. 
     According to some embodiments, the various systems disclosed herein can be used to treat one or more skin conditions of a subject. For example, the systems can be used to target the following conditions/target treatments: acne, skin lightening, skin tightening, anti-aging, oily skin, lip repair/plumping and/or the like. Example treatment protocols for at least some of the conditions/target treatments are provided below. For example, in some arrangements, protocols identical or similar to those provided in Table A below can be used. 
     
       
         
           
               
               
               
               
             
               
                 TABLE A 
               
               
                   
               
               
                   
                 Step 1 Fluid Active 
                 Step 2 Fluid Active 
                 Step 3/4 Fluid 
               
               
                 Protocol/Procedure 
                 Ingredients 
                 Ingredients 
                 active ingredients 
               
               
                   
               
             
            
               
                 Acne 
                 Preparatory/Exfoliating 
                 Treatment agent 
                 A treatment 
               
               
                   
                 agent with salicylic acid 
                 (e.g., anti-oxidants, 
                 agent consisting 
               
               
                   
                 or other agent that will 
                 silver, in 
                 of oil free 
               
               
                   
                 breakdown oils and dead 
                 combination with 
                 moisturizing 
               
               
                   
                 tissues on the surface 
                 one or more agents 
                 agents combined 
               
               
                   
                 layers of the skin 
                 such as benzyl 
                 or applied 
               
               
                   
                   
                 peroxide. Salicylic 
                 separately with 
               
               
                   
                   
                 acid or sulfur. 
                 agents to block 
               
               
                   
                   
                   
                 UV rays and 
               
               
                   
                   
                   
                 other oxidizing 
               
               
                   
                   
                   
                 elements. 
               
               
                 Skin lightening 
                 Preparatory/Exfoliating 
                 A treatment agent 
                 A treatment 
               
               
                   
                 agent with salicylic acid 
                 consisting of but not 
                 agent consisting 
               
               
                   
                 or other agent that will 
                 limited to, avena 
                 of moisturizing 
               
               
                   
                 breakdown oils and dead 
                 sativa (oat) kernel 
                 agents combined 
               
               
                   
                 tissues on the surface 
                 extract, Palmaria 
                 or applied 
               
               
                   
                 layers of the skin 
                 palmatate, 
                 separately with 
               
               
                   
                   
                 horsechest nut and 
                 agents to block 
               
               
                   
                   
                 green tea extract. 
                 UV rays and 
               
               
                   
                   
                   
                 other oxidizing 
               
               
                   
                   
                   
                 elements. 
               
               
                 Skin tightening 
                 Preparatory/Exfoliating 
                 A treatment agent 
                 A treatment 
               
               
                   
                 agent with salicylic acid 
                 consisting of but not 
                 agent consisting 
               
               
                   
                 or other agent that will 
                 limited to, avena 
                 of moisturizing 
               
               
                   
                 breakdown oils and dead 
                 sativa (oat) kernel 
                 agents combined 
               
               
                   
                 tissues on the surface 
                 extract, Palmaria 
                 or applied 
               
               
                   
                 layers of the skin. 
                 palmatate, 
                 separately with 
               
               
                   
                   
                 horsechest nut and 
                 agents to block 
               
               
                   
                   
                 green tea extract. 
                 UV rays and 
               
               
                   
                   
                   
                 other oxidizing 
               
               
                   
                   
                   
                 elements. 
               
               
                 Anti-aging 
                 Preparatory/Exfoliating 
                 A treatment agent 
                 A treatment 
               
               
                   
                 agent with salicylic acid 
                 consisting of but not 
                 agent consisting 
               
               
                   
                 or other agent that will 
                 limited to 
                 of moisturizing 
               
               
                   
                 breakdown oils and dead 
                 transdennal 
                 agents combined 
               
               
                   
                 tissues on the surface 
                 application of 
                 or applied 
               
               
                   
                 layers of the skin. 
                 antioxidants, such 
                 separately with 
               
               
                   
                   
                 as but not limited 
                 agents to block 
               
               
                   
                   
                 to, lipoic acid 
                 UV rays and 
               
               
                   
                   
                 bioflavonoid, 
                 other oxidizing 
               
               
                   
                   
                 (aesculus 
                 elements. 
               
               
                   
                   
                 hippocastanum) 
                   
               
               
                   
                   
                 horse chestnut, 
                   
               
               
                   
                   
                 proanthocyanidin 
                   
               
               
                   
                   
                 and a mixture of 
                   
               
               
                   
                   
                 amino acids 
                   
               
               
                   
                   
                 combined with 
                   
               
               
                   
                   
                 sulfur and or benzyl 
                   
               
               
                   
                   
                 alcohol or other 
                   
               
               
                   
                   
                 penetrant enhancers. 
                   
               
               
                 Oily skin 
                 Preparatory/Exfoliating 
                 Treatment agent 
                 A treatment 
               
               
                   
                 agent with salicylic acid 
                 (e.g., anti-oxidants, 
                 agent consisting 
               
               
                   
                 or other agent that will 
                 silver, in 
                 of oil free 
               
               
                   
                 breakdown oils and dead 
                 combination with 
                 moisturizing 
               
               
                   
                 tissues on the surface 
                 one or more agents 
                 agents combined 
               
               
                   
                 layers of the skin 
                 such as benzyl 
                 or applied 
               
               
                   
                   
                 peroxide, Salicylic 
                 separately with 
               
               
                   
                   
                 acid or sulfur. 
                 agents to block 
               
               
                   
                   
                   
                 UV rays and 
               
               
                   
                   
                   
                 other oxidizing 
               
               
                   
                   
                   
                 elements. 
               
               
                 Lip Repair/Plumping 
                 Preparatory/Exfoliating 
                 Treatment agent 
                 A treatment 
               
               
                   
                 agent with salicylic acid 
                 (e.g., anti-oxidants 
                 agent consisting 
               
               
                   
                 or other agent that will 
                 and collagen 
                 of moisturizing 
               
               
                   
                 breakdown oils and dead 
                 building 
                 agents combined 
               
               
                   
                 tissues on the surface 
                 Ingredients such as 
                 or applied 
               
               
                   
                 layers of the skin 
                 but limited to amino 
                 separately with 
               
               
                   
                   
                 acids such as 
                 agents to block 
               
               
                   
                   
                 palmitoyl dipeptide- 
                 UV rays and 
               
               
                   
                   
                 10. palmitoyyl 
                 other oxidizing 
               
               
                   
                   
                 dipeptide-1,7, 
                 elements. 
               
               
                   
                   
                 palitoyl 
                   
               
               
                   
                   
                 hexipeptide-12. 
                   
               
               
                 Anti-oxidant/growth 
                 Preparatory/Exfoliating 
                 Apply Epicatechin 
                 Antioxidant(s) 
               
               
                 factor treatment 
                 agent with salicylic acid 
                 (e.g., synthetic 
                 and/or other 
               
               
                   
                 or other agent that will 
                 and/or naturally 
                 agents. 
               
               
                   
                 breakdown oils and dead 
                 derived) and/or 
                 In some 
               
               
                   
                 tissues on the surface 
                 other growth 
                 embodiments, 
               
               
                   
                 layers of the skin 
                 factor(s). 
                 the process can 
               
               
                   
                   
                 In some 
                 include the 
               
               
                   
                   
                 embodiments, allow 
                 application of 
               
               
                   
                   
                 sufficient time to 
                 additional 
               
               
                   
                   
                 dry before 
                 agents, such as, 
               
               
                   
                   
                 continuing to the 
                 e.g., 
               
               
                   
                   
                 next step. In some 
                 sunscreen(s), as a 
               
               
                   
                   
                 arrangements, 
                 follow up step. 
               
               
                   
                   
                 Epicaeichin could 
                 In one 
               
               
                   
                   
                 be in a powder form 
                 embodiment, the 
               
               
                   
                   
                 that needs to be 
                 sunscreen can be 
               
               
                   
                   
                 mixed just prior to 
                 30SPF or greater 
               
               
                   
                   
                 application 
               
               
                   
               
            
           
         
       
     
     According to some embodiments, with reference to the Epicatechin treatment listed above can be included in a take home unit, as described in greater detail herein. In some embodiments, the Epicatechin product is applied daily morning and/or night. The Epicatechin could be provided in the form of a lotion, cream or serum, wax lipstick delivery medium and/or the like. In some embodiments, antioxidant product(s) is/are applied daily morning and/or night. Like the Epicatechin product, antioxidants could be provide as a lotion, cream or serum, wax lipstick delivery medium and/or the like, as desired or required. 
     For example, as indicated in Table A above, in some embodiments, the initial step of a treatment protocol comprises one or more preparatory steps or procedures. For example, in some arrangements, the subject&#39;s skin is initially exfoliated, at least partially, regardless of the exact protocol being used. In some configurations, salicylic acid or other agent that will breakdown oils and dead skin tissue on the surface layers of the subject&#39;s skin can be selectively delivered to the skin of a subject. The delivery of such preparatory fluids can be performed using a device disclosed herein (e.g., a vacuum-assisted assembly). Alternatively, such materials can be delivered to the skin surface using one or more other methods or devices (e.g., topically applied without the use of separate device). In some embodiments, the delivery of fluids while suction is applied to the skin (e.g., via a suction-enabled assembly) can facilitate the delivery of fluids below the outermost surface of the skin to thereby enhance the initial preparatory step of a procedure or protocol. 
     With further reference to Table A, as a second step to a treatment procedure, a first treatment agents or combination of treatment agents (e.g., anti-oxidants, silver, benzyl peroxide, salicylic acid, sulfur,  Avena sativa  (oat) kernel extract, palmaria palmatate, horsechest nut, green tea extract, lipoic acid bioflavonoid, ( Aesculus hippocastanum ) horse chestnut, proanthocyanidin and a mixture of amino acids combined with sulfur and or benzyl alcohol or other penetrant enhancers and/or the like can be delivered to the skin via the rollerball, wincing material and/or the like. 
     Further, with continued reference to Table A, as a third step to a treatment procedure, a second treatment agents or combination of treatment agents (e.g., anti-oxidants, silver, benzyl peroxide, salicylic acid, sulfur,  Avena sativa  (oat) kernel extract, palmaria palmatate, horsechest nut, green tea extract, lipoic acid bioflavonoid, ( Aesculus hippocastanum ) horse chestnut, proanthocyanidin and a mixture of amino acids combined with sulfur and or benzyl alcohol or other penetrant enhancers and/or the like can be delivered to the skin via the rollerball, wincing material and/or the like. 
       FIGS. 16 and 18  schematically illustrate different embodiments of a system having a handpiece or other skin treatment component configured to contact skin along one end. As discussed herein, such a handpiece or other component can comprises a rollerball, wicking members and/or the like. As shown in  FIGS. 16 and 18 , a conduit (e.g., vacuum tubing) can be used to place the handpiece or other treatment component in fluid communication with a vacuum source (e.g., a vacuum unit). In some embodiments, one or more both ends of the conduit can include a sensor to ensure that a satisfactory connection is made with the handpiece and the vacuum source before the system can be activated. One or more wires, conduits, cables and/or other electrical connections can be included in the system to facilitate the necessary connection to the sensor(s) and/or other electrical components. In other embodiments, the necessary electrical and/or data connections are wireless (e.g., Bluetooth). Regardless of the exact configuration, such handpiece sensing features can permit the system to operate when the electrical and/or date circuit is completed. 
       FIGS. 17A and 17B  illustrates different embodiments of systems that comprise a cartridge assembly that is configured to at least partially absorb and/or otherwise retain waste material being removed from the skin (e.g., spent serums and/or other treatment materials, exfoliated skin, other debris, etc.). For example, in one embodiment, a cartridge assembly that is in fluid communication with a vacuum source, as depicted in  FIG. 17B , can be sized, shaped and/or otherwise configured to receive a removable solid cleaning cartridge. Such a removable cartridge can be advantageously removed, discarded and replaced, thereby reducing exposure of waste materials during routine maintenance, cleaning and/or other normal operation of the system. As shown, the receptacle into which the solid cleaning cartridge is placed can include a central conduit having a plurality of openings, pores and/or the like that place the central conduit in fluid communication with the removable cartridge. In some embodiments, as discussed in greater detail herein, such a cartridge can comprise a porous, wicking, absorptive and/or other material configured to at least partially receive and/or retain fluids and/or other materials. 
       FIG. 18  schematically illustrates one embodiment of a system that comprises sensors along both the handpiece and the vacuum source to ensure proper connection of conduits of the system. In some arrangements, the sensors can help identify the components that are used in the system. This can provide a level of security that the components are intended to be used with one another, and that no unintended components that can interfere with the proper function of the system are included in a particular arrangement. 
       FIGS. 19A and 19B  illustrate different views of yet another embodiment of a skin treatment assembly  2000  comprising a rollerball (and/or another porous, wicking, other absorbent material or member, and/or the like)  2044  along its distal end  2042 . As with other embodiments disclosed herein, the rollerball or other member positioned along the distal end  2044  can facilitate delivery of fluids and/or other materials to a subject being treated with the assembly  2000 . In some embodiments, as illustrated in  FIG. 19A , the assembly  2000  can include a cartridge or other container  2040 . Further, the distal end  2010  of the assembly  2000  can include a handpiece portion  2110  that is sized, shaped and/or otherwise adapted to secure to the distal end of the cartridge  2040 . 
     With continued reference to  FIG. 19A , the handpiece portion  2110  can be configured to fit over the distal end of the cartridge or other container  2040  such that a rollerball or other member (e.g., wicking member, porous member, absorptive member, etc.)  2040  located along the distal end of the container  2040  can extend to the distal end of the assembly  2000 . For example, in some embodiments, such a rollerball or other member  2044  can form the most distal surface of the assembly once the handpiece portion  2110  is secured to the cartridge or other container  2040 . In other embodiments, however, the distal end of the rollerball or other member that is configured to facilitate delivery of fluid(s) to the skin surface of a subject is aligned with, generally aligned with or proximal to another portion of the handpiece assembly  2110  and/or another portion or component of the assembly  2000 , as desired or required. Thus, in some configurations, the assembly  2000  relies, at least in part, on suction or vacuum created along the distal end of the assembly to draw the targeted skin surface toward (e.g., adjacent to, in contact with, etc.) the rollerball and/or other distal member  2044 , as desired or required. 
     As discussed with respect to other embodiments herein, the use of vacuum or suction to help draw the tissue toward the rollerball or other distal member (e.g., wicking member, porous member, absorptive member, etc.) can help enhance a skin treatment procedure. For example, the ability to selectively delivery fluids and/or other substances or materials (e.g., included within the cartridge or other container that is physically coupled to and/or in fluid communication with a container, e.g., a multi-container manifold system) can be improved and/or otherwise enhanced by the use of suction or vacuum. For example, the application of a vacuum or suction force along the tip can help deliver fluids and/or other substances to the skin surface being treated at a controlled rate of delivery. This can be contrasted with embodiments that rely only on gravity to deliver fluids and/or other materials to the skin surface. The use of a vacuum or suction force (e.g., once a seal has been created between a distal lip or periphery of a tip or other distal portion of an assembly, in accordance with various embodiments disclosed herein), can help ensure that fluid and/or other materials contained within a container (e.g., cartridge) and/or other fluid system with which the assembly  2000  is in fluid communication (e.g., a manifold system) is consistently and adequately delivered to the targeted skin surface. This is applicable to and may be specifically adapted for any of the embodiments disclosed herein. 
     With continued reference to  FIG. 19A , the handpiece portion  2110  of the assembly  2000  can include a port  2112  that is adapted to be coupled to a vacuum or suction source. In some embodiments, as shown in  FIG. 19A , the suction port  2112  can be positioned, at least partially, along an exterior of the assembly. However, in other embodiments, the port  2112  and/or corresponding passage (e.g., conduit) to with which the port is placed in fluid communication can extend, at least partially, along an interior of the assembly. For example, in some arrangements, the port and/or the corresponding passage can extend, at least in part, along the interior of the assembly, as desired or required. 
     As discussed with reference to other embodiments herein, the distal end of the assembly  2000  (e.g., the distal end of the handpiece portion  2110 , the cartridge or other container  2040 , a separate tip and/or any other component or portion) can include a peripheral lip or edge that is configured to contact the subject&#39;s skin. In some embodiments, such a lip and/or other periphery can help establish a seal with the adjacent tissue surface to ensure that, when a vacuum or suction source is activated, the targeted skin surface is engaged by the lip and/or other periphery. In some arrangements, this facilitates the delivery of fluids to the tip and removal of spend fluids and/or other debris (e.g., exfoliated skin) away from the tip. 
       FIGS. 20A and 20B  illustrate different longitudinal cross-sectional views of the assembly depicted in  FIGS. 19A and 19B . As shown, the distal end of the container (e.g., a cartridge, a handpiece assembly, a tip, etc.) that includes the rollerball or other fluid delivery member (e.g., absorptive member, a wicking member, etc.)  2044 . As shown, the distal end  2042  of the assembly  2000  can be tapered and/or otherwise include a reduced diameter or cross-sectional dimension, as desired or required. For example, in some embodiments, the distal end  2010  of the assembly  2000  along or near which the rollerball or other fluid delivery member (e.g., absorptive member, a wicking member, etc.)  2044  is positioned or otherwise located can include a diameter or other cross-sectional dimension that is 20% to 70% (e.g., 20-30, 30-40, 40-50, 50-60, 60-70%, ranges between the foregoing, etc.) smaller than adjacent portions of the assembly. 
     With continued reference to  FIGS. 20A and 20B , the assembly  2000  can comprise a distal end  2010  that includes a tapered portion  2042 . As shown, a rollerball or other fluid delivery member  2044  can be positioned along the distal end of the tapered portion  2042  and/or other portion of the distal end of the assembly  2000 , as desired or required. As with other embodiment disclosed herein, the rollerball or other fluid delivery member  2044  can be in fluid communication with a main portion of the reservoir or compartment that contains fluid via one or more passageways  2048  along the tapered distal end  2042 . In some configurations, the rollerball and/or other member (e.g., wicking member, porous member, etc.)  2062  can be resiliently biased distally using one or more springs and/or other resilient members or portions  2050 . Such a configuration can be implemented in any of the embodiments disclosed herein or variations thereof. 
     Thus, according to some embodiments, the rollerball or other member  2044  is resiliently biased in a distal orientation. In such configurations, the rollerball or other fluid delivery member  2044  is normally configured to form a seal  2062 . As a result, in such a configuration, fluids and/or other materials (e.g., contained within a cartridge and/or otherwise in fluid communication with the rollerball or the fluid delivery member  2044 ) are prevented from exiting past the rollerball or other fluid delivery member  2044 . In some embodiments, pressing or otherwise moving the rollerball and/or other fluid delivery member  2044  (e.g., wicking member, porous member, etc.) inwardly (e.g., against the force created by the spring 2050 or other biasing or resilient member) can create clearance between the rollerball or other member  2044  and the adjacent housing, thereby allowing fluid to flow around the rollerball or other member toward the distal end of the assembly  2000 . 
     In some embodiments, however, if sufficient force is imparted upon the rollerball or other assembly  2044 , the rollerball or other assembly  2044  can abut against a distal surface  2064  of the housing and/or other portion of the assembly to prevent further fluids and/or other materials from exiting toward the distal end of the assembly. Thus, in some embodiments, one or more resilient members (e.g., springs)  2050  can help regulate the passage of fluid from a reservoir (e.g., from within a cartridge or other portion of the assembly) to the tip of the assembly  2000 , as desired or required. In some embodiments, the force that is applied against the spring or other resilient member  2050  regulates the amount of flow (e.g., flowrate) that moves past the rollerball and/or another fluid delivery member  2044  located along eth distal end of the assembly  2000 . Such a configuration can be applied to any of the embodiments disclosed herein. In some embodiments, moving the rollerball and/or any other distal member  2044  too far against the biasing force may cause the rollerball or the member to seat against a proximal portion  2064  that will once again prevent flow from to the distal end of the assembly. Thus, in some embodiments, there exists a range within which the rollerball or other resiliently-biased member  2044  can be moved in order to regulate flow to the distal end of the assembly  2000 . 
     As noted herein, e.g., with reference to, among other embodiments,  FIGS. 10 and 11 , a handpiece assembly can include one or more wicking and/or other porous (e.g., fluidly porous) members that are configured to facilitate the delivery of fluid (e.g., water, other serum or treatment material, etc.) to the distal end (e.g., to the tip or other distal member or portion) of the handpiece assembly. Accordingly, as the handpiece assembly  3000  is moved relative to a subject&#39;s skin surface, the wicking member  3044  can facilitate the delivery of water or other fluids from a fluid source (e.g., a fluid reservoir of a cartridge or other container  3040 , another container that is secured to the handpiece assembly or is separate from the handpiece assembly, etc.) to the skin surface. The wicking member  3044  can comprise one or more porous materials or features, such as, for example, foam, a porous stone, sponge or other member, another material or member comprising a porous or otherwise open or semi-open structure. In some embodiments, the wicking or other porous member  3044  can be saturated with the particular fluids contained within the reservoir of the cartridge or other container member (e.g., before, during and/or after use). Thus, the porous member (e.g., wicking member)  3044  can retain the necessary moisture level to selectively deliver fluid to the skin surface treated, even when the level of fluid within the cartridge or the other container  3040  is relatively low. 
     As illustrated in the cross-sectional view of  FIG. 21C , the porous or wicking member  3044  extends at least partially within the container  3040  on one end and at least partially through the tip or other distal member or portion  3020 . As shown, the distal member or portion  3020  comprises a tip that is removably secured to the distal end of the cartridge or other container  3020 . However, in other embodiments, the handpiece assembly  3000  comprises a different structure or design, as desired or required. For example, the handpiece assembly  3000  can include a unitary or monolithic structure, wherein the container and the tip or other distal member or portion form a single or non-separable construction. 
     In some embodiments, with continued reference to  FIG. 21C , the wicking or other porous member  3044  can extend entirely or almost entirely through the length of the tip  3020  or other distal member or portion. For example, in some arrangements, the porous member  3044  extends between 50% to 100% (e.g., 50-60, 60-70, 70-80, 80-90, 90-100%, percentages between the foregoing ranges, etc.) of the length of the tip or other distal member  3020 . However, in other embodiments, the porous member  3040  extends through less than 50% (e.g., 0-10, 10-20, 20-30, 30-40, 40-50%, percentages between the foregoing, etc.) of the length of the tip, as desired or required. Thus, the wicking or porous member can draw fluid from the interior of the container  3040  and quickly and consistently deliver it to the tip  3020 . This can advantageously improve the manner in which fluids are delivered to a skin surface being treated during a procedure. In some embodiments, the use of porous members or structures like those disclosed herein can facilitate fluid transfer from a container to the skin surface irrespective of the orientation and/or position of the handpiece assembly relative to the subject&#39;s skin. 
     As discussed herein with reference to other embodiments, the depicted porous or wicking member  3044  can comprise one or more foams, thermoplastics and/or other materials. The cross-sectional size of the wicking member can be between ¼ inch and 2 inches or more. In some embodiments, the wicking member  3044  extends, at least partially, within the interior reservoir of the cartridge or other container. The wicking member  3044  can include any cross-sectional shape, as desired or required, such as, for example, circular, oval, square or other rectangular, other polygonal (e.g., triangular, pentagonal, hexagonal, octagonal, decagonal, etc.), irregular. In some embodiments, any of the porous members (e.g., wicking members) disclosed herein can be configured to transport liquids and/or other fluids through their structure via capillary action. In addition, the porous members (e.g., wicking members) disclosed herein can comprise one or more rigid and/or semi-rigid materials. 
     According to some embodiments, as illustrated in  FIGS. 21A-21E , the handpiece assembly  3000  is configured to be coupled to a vacuum or suction source (not shown). As shown, the tip  3020  and/or any other portion of the assembly  3000  can comprise one or more openings, passageways or channels  3042  that place the distal end of the tip  3020  in fluid communication with a vacuum coupling  3042 . In some embodiments, the vacuum coupling  3042  can include a luer and/or any other standard or non-standard coupling or connector. Such a coupling, irrespective of its exact design and configuration, can be adapted to couple to and be placed in fluid communication with a vacuum conduit or line that is fluidly coupled to a vacuum or suction source (e.g., a vacuum pump). In some configurations, the passageway  3042  is configured to extend, at least partially, through an interior of the tip  3020  and/or another portion of the assembly  3000 , as shown in  FIG. 21C . However, in other embodiments, the passageway  3042  can extend, at least partially, through an exterior of the tip  3020  and/or another portion of the assembly  3000 . Further, the passageway  3042  can terminate at or near one or more ports or openings  3028  along the distal end of the tip  3020 . 
     In some embodiments, the tip  3020  or other distal member or portion of the assembly  3000  can include one, two or more suction ports and/or passages, as desired or required. The quantity, size, shape, orientation and/or other details about any suction ports/passages included on a tip can vary, depending on the particular design. In some arrangements, the vacuum or suction ports are located on the cartridge or other container  3040 . 
     In some embodiments, the suction passages or conduits  3042  terminate at the distal end of the tip or other distal member  3020 , as shown, for example, in  FIG. 21C . However, in other arrangements, the suction passages or conduits terminate proximal to the distal end of the tip or other distal portion of the assembly (e.g., before or proximal to the distal end of the tip or other distal member), as desired or required. In some embodiments, the suction passages or conduits  3042  can extend entirely or almost entirely through the length of the tip  3020 , another distal portion and/or any other portion or member of the handpiece assembly  3000 . For example, in some arrangements, the suction passages or conduits  3042  extend between 50% to 100% (e.g., 50-60, 60-70, 70-80, 80-90, 90-100%, percentages between the foregoing ranges, etc.) of the length of the tip  3020 . However, in other embodiments, the suction passages or conduits  3042  extend through less than 50% (e.g., 0-10, 10-20, 20-30, 30-40, 40-50%, percentages between the foregoing, etc.) of the length of the tip  3020 . 
     In some embodiments, the distal end of the tip or other distal member  3020  comprises a peripheral lip  3022  that is configured to create a partial or complete seal between the tip or other distal member and a skin surface when the tip  3022  is placed against the subject&#39;s skin during use. For example, a peripheral lip  3022  of the tip or other distal member or portion  3020  can extend outwardly so as to contact skin tissue and circumscribe an interior region  3023  of the tip during use. The lip can include a generally smooth outer surface (e.g., the outer surface that is configured to contact skin and form a seal relative to skin). In some arrangements, the use of vacuum (e.g., via activation of a vacuum or suction force, the couplings, connectors, conduits, channels and/or other members or features  3012 ,  3042  that place such a source in fluid communication with the interior region, etc.) is configured to draw the skin surface toward the tip or other distal member to at least partially seal it against the peripheral lip. The creation of such a seal and the delivery of a vacuum force along the interior region  2023  defined by the peripheral lip  3022  can facilitate the delivery of fluid from the cartridge  3040  or other container to the tip  3020 . Further, the vacuum or suction force can cause skin located along the interior region  3023  of the tip or other distal member  3020  to be at least partially drawn within the interior region  3023  (e.g., toward the tip and the handpiece assembly). This can facilitate and/or enhance contact between the tip or other distal member  3020  and the skin surface being treated. 
     As noted above, in some arrangements, the creation of a vacuum or suction force along the interior region  3023  can advantageously permit enhanced fluid delivery from the cartridge or other fluid container  3040  to the tip or other distal member  3020 . The amount of suction generated can be adjusted to modulate this effect (e.g., to regulate the amount of fluid delivered to the tip, the rate at which the fluid is delivered to the tip, etc.). In some embodiments, the use and generation of vacuum along the tip also advantageously facilitates the removal of spent fluid and/or exfoliated skin from the tip or other distal member. 
     In some embodiments, the peripheral lip  3022  and/or other interior abrading member(s) and/or feature(s) of the tip and/or other distal portion or member  3020  of the assembly  3000  can be configured to at least partial abrading of tissue when the handpiece assembly is moved relative to a skin surface (e.g., especially when vacuum is being applied to the tip). In some arrangements, the tip or other distal member can include one or more abrasive features, surfaces and/or the like (for example, one or more abrading members, spiral members, posts, abrasive surfaces, abrasive pads, etc.) such that when the tip or other distal member is moved relative to a targeted skin surface (e.g., especially upon activation of a vacuum source that draws the tip toward and/or engaged with the targeted skin surface), at least portions of the targeted skin surface can be selectively abraded or otherwise removed. Further, in some embodiments, the abrasion members or features (e.g., spiral interior members) can facilitate the extraction of at least one of blackheads, sebum and/or any other substances from the skin (e.g., with the assistance of the application of vacuum, twisting and/or other actions, depending on the protocol). Such abrasive members or features can be incorporated into any embodiments disclosed herein or variations thereof. In other embodiments, the handpiece assembly of  FIGS. 21A-21E  does not include any abrasive structures or features. 
     In some embodiments, the porous/wicking member  3080  positioned within the assembly  3000  is configured to at least partially contact the skin surface being treated during use. However, in other arrangements, as shown in  FIG. 21C , a small passage, opening or space  3060  is included between the distal end of the porous/wicking member  3060  and the interior region  3023  defined by the peripheral lip  3022  along the distal end of the tip or other distal member  3020 . Such a passage or opening  3060  can be sized, shaped and otherwise configured to deliver fluid (e.g., water, serums, other liquids or fluids, other materials, etc.) from the porous/wicking member  3080  to the distal end of the tip or other distal member  3020  during use (e.g., prior to and/or during the activation of vacuum). In some embodiments, two or more openings  3060  can be included to transfer fluids between the porous member  3080  and the interior region  3023  along the distal end of the tip. In yet other arrangements, a separate porous member or feature can be positioned between the porous member  3080  and the interior region  3023  to help regulate the passage of fluids to the distal end of the tip  3020 . 
     In any of the embodiments disclosed herein, the porous or wicking member  3080  can include one or more openings that extend through the porous/wicking member that are separate and different from the passageways inherently present in the porous structure itself. For example, such separate openings or passageways can extend at least partially longitudinally and/or radially along one or more portions of the porous member  3080 . In some embodiments, such openings or passageways can be configured to convey water or other fluids through the porous/wicking member at a faster rate than through adjacent portions of the porous member. In some embodiments, such separate passageways can be configured to deliver air (e.g., continuously, intermittently, in a pulsed manner, etc.) to the skin surface. In other arrangements, the openings can be configured to deliver a separate fluid or other material (e.g., medicament, serum, other liquid or non-liquid material, etc.) to the skin surface during use. The diameter, shape, and orientation of the passageways and/or other openings can vary depending on the intended use, application and/or intended function or purpose, for example, to adjust the rate of flow of fluid or other substances through the porous/wicking member. In some embodiments, such passageways have a circular or curved cross-sectional shape. In some embodiments, they have an annular shape. 
     In some embodiments, one or more portions of the wicking or porous member  3080  can be at least partially hollow. In other arrangements, the porous member  3080  can be at least partially filled with substances, materials and/or structures, such as, for example, additional porous/wicking members having different properties than the first porous/wicking member, gels, solids, liquids and/or materials (e.g., either in loose form or in a contained manner, such as, in dissolvable or releasable capsules or other enclosures). In some embodiments, a porous member  3080  can include two or more passageways, other members and/or the like. 
     In some embodiments, as illustrated in  FIG. 21C , the porous member  3080  comprises an internal reservoir or region  3084  (e.g., a fibrous reservoir or portion). In some arrangements, the internal reservoir or region  3084  is positioned entirely within the porous/wicking member  3080 . However, in other arrangements, the internal reservoir or region  3084  is positioned adjacent to and/or at least partially external to the porous member  3080 . Regardless of its exact orientation, size, shape and/or other properties, the internal reservoir  3084  can include a flexible or other non-rigid design. For example, in some embodiments, the internal reservoir is at least partially filled with one or more felt materials and/or any other absorbent or semi-absorbent materials or features (e.g., sponge, sponge-like materials, cotton, cloth, fabric, porous foams, filters, etc.). In other embodiments, the internal reservoir  3084  is hollow or at least partially hollow. This can facilitate the passage of water or other liquids through those portions of the porous member  3080 . 
     According to some embodiments, the internal reservoir or region  3084  is configured to store or otherwise contain one or more treatment materials (e.g., in solid, gel, liquid and/or any other form) that are configured to at least partially dissolve or be released in the presence of water or other liquids. Thus, as water or other liquids are drawn from the cartridge or other container  3040  through the porous member  3080  (e.g., via the application of vacuum or suction), materials contained within the internal reservoir  3084  and/or within other portions of the porous member (e.g., the rigid or semi-rigid portions of the porous member  3080 ) can be dissolved and carried to the tip-skin interface to enhance a treatment procedure. Such a configuration can simplify the manner in which serums and/or other treatment materials are delivered to the tip, can avoid having to store the treatment fluids within cartridges or other containers, can allow users to reuse cartridges and containers (e.g., by simply refilling them with water or another liquids) and/or provide additional benefits and advantages. 
     In some embodiments, the tip or other distal member  3020  is attached to the cartridge or other container by a press fit connection, friction fit connection, threaded connection, other mechanical connection and/or the like. In some embodiments, as shown in  FIGS. 21A-21E , the tip  3020  is connected directly to the container, and the handpiece assembly includes only the tip and container. But in other embodiments, additional portions can be included, e.g., a separate main body portion of the handpiece assembly that is configured to receive a cartridge or other container. For example, in some embodiments, the main body portion can include one or more interior and/or exterior recesses or other receiving areas or portions that are sized, shaped and otherwise configured to receive a cartridge or other container. Such arrangements can facilitate the fast and easy removal and replacement of containers. In some embodiments, the container can include a connection to a fluid manifold system. 
     In some embodiments, the porous or wicking member  3080  can be removable or replaceable and porous/wicking members with different properties (e.g., containing different materials) can be used. For example, porous members  3080  can be selected based on the materials they contain, their fluid transfer properties, other properties (e.g., absorbability, density, porosity, abrasiveness, etc.) and/or the like, as desired or required. 
     In some embodiments, the porous/wicking member  3080  is configured to contact skin tissue, for example, before or during use of the handpiece. In some arrangements, the porous/wicking member  3080  can include an abrasive structure or design (for example, one or more abrasive surfaces or features, such as, abrasive edges, members, etc.). In some embodiments, the tip or other distal portion of the porous/wicking member can include an abrasive surface or be otherwise configured to abrade tissue when the handpiece is moved relative to targeted skin tissue. 
     As noted herein, in some embodiments, positioning a porous member  3080  that is situated at least partially within a container (e.g., a cartridge) and extends to or near the distal end (e.g., to the tip) of the handpiece assembly  3000  can facilitate the transfer of fluids to the tip. In some embodiments, the transfer of fluids is enhanced by the use or porous materials or other structures (e.g., via capillary action), the generation of vacuum or suction along the tip and/or other factors. 
       FIG. 21E  illustrates an exploded, perspective view of the handpiece assembly of  FIGS. 21A-21D . As shown and discussed above, the porous or wicking member  3080  can be removable from the assembly  3000 . In some embodiments, the porous member  3080  is configured to be removed (e.g., for disposal, replacement, etc.) by separating the tip  3020  from the container  3040 . However, in other configurations, the porous member  3080  can be configured to be positioned into and/or removed from the handpiece assembly  3000  using a different method or procedure. As shown, the porous member  3080  can include one or more slots or recesses  3082  along one or more of its exterior surfaces. Such features  3082  can assist with properly aligning the porous member  3080  with and positioning the member  3080  relative to adjacent portions of the assembly  3000  (e.g., internal portions of the tip  3020  and/or the container  3040 ). 
     In some embodiments, as illustrated in  FIGS. 22A-22E , one or more portions of the tip or other distal portion  3120  of the handpiece assembly  3100  can comprise one or more treatment materials  3190  that are configured to at least partially dissolve or otherwise release during use. For example, such materials can be embedded onto one or more surfaces, features (e.g., within cavities, posts or other abrasive members, etc.) of the tip, as desired or required. The embedded materials or other products  3190  positioned along or near the tip  3120  can come in any form (e.g., solids, liquid, gel, powder, etc.). In some arrangements, the use of such materials  3190  on or near the tip  3120  can be in lieu of or in addition to the use of dissolvable or otherwise releasable materials within the porous/wicking member (not shown in  FIGS. 22A-22E ). 
     In any of the embodiments disclosed herein (e.g., the assemblies of  FIGS. 21A-21E and 22A-22E ), the tips and/or the porous members can include one or more dissolvable or releasable materials. Alternatively, such materials can be included in premixed (ready to use) liquids contained within the container or other cartridge  3040 ,  3140 . Regardless, such materials can include, without limitation, skin tightening agents, platelet-rich plasma (PRP), exfoliation agents, peptides, bleaching agents, anti-acne agents, human growth factors, cytokines, soluble collagen, antioxidants, matrix proteins, Epicatechin, Catechin and/or other phenols and/or other anti-oxidants, neurotoxins, serums, salicylic acid, other anti-acne acids and materials, microcapsules, capsules, other time-release products and substances, water (e.g., distilled, tap water, filtered, etc.), saline, other dilution agents, dilutants or dissolvents, vitamins, chemical exfoliation agents, lotions, soothing agents, brightening or lightening agents, peptides, peeling agents, acids, anesthetics, medicants, other non-active or active compounds, other fluids or materials, combination or mixtures thereof and/or any other substance from one or more internal/external fluid sources. 
     For any of the embodiments disclosed herein, a cartridge or other fluid source configured to be used in an assembly (e.g., to couple to a handpiece), the cartridge can include two or more compartments that are fluidly isolated from one another. For example, in some arrangements, a cartridge includes two or three chambers, each of which is configured to store a different serum and/or treatment material to be used during a specific treatment procedure. In some embodiments, such a multi-compartment cartridge or other fluid source is separated by walls, baffles or other members or features. In some embodiments, a user can choose between the various compartments of the cartridge (and thus, the various serums and/or other materials to be delivered to the subject&#39;s skin surface) using one or more selection features, methods or devices. For example, the cartridge, handpiece, tip and/or other portion of the assembly can include one or more controllers (e.g., switches, levers, knobs, etc.) that permit a user to select the specific compartment of the cartridge from which fluids and/or other materials will be transferred to the subject&#39;s skin. In other embodiments, the orientation of the cartridge within the handpiece dictates which compartment will be in fluid communication with the assembly&#39;s internal passages and the tip. For example, the rotational or angular orientation of the cartridge relative to the handpiece can determine which compartment of the cartridge will be accessed by the rollerball. 
     In any of the assembly embodiments disclosed herein or variations thereof, the tip can be placed in fluid communication with a fluid manifold system. Thus, one or more fluids from such a manifold system or station can be selectively delivered to the assembly. Accordingly, in some embodiments, a dummy cartridge or a simple fluid conduit can be used (e.g. instead of a filled cartridge) to interface with such a manifold system or station. 
     According to certain embodiments, a cartridge or other container is placed in fluid communication with a manifold system that may comprise a plurality of individual fluid conduits. In turn, one or more of these fluid conduits can be in fluid communication with a separate container. For example, in some embodiments, such fluid conduits can be in fluid communication with containers of a tower system. In one embodiment, the individual fluid lines are in fluid communication with a main fluid conduit, which connects to a nozzle along a proximal end of a cartridge or other container secured within the handpiece. One or more of the fluid conduits can comprise a valve or other flow control device or feature to selectively regulate the transfer of fluids and/or other materials to the assembly. In the some arrangements, the manifold system comprises a total of four fluid branches. However, a system can comprise more or fewer fluid branches (e.g., 1, 2, 3, 4, 5, 6, 7, 8, more than 8, etc.), as desired or required by a particular application or use. Additional details regarding a manifold system or tower are provided in U.S. patent application Ser. No. 11/392,348, filed on Mar. 29, 2006 and issued as U.S. Pat. No. 8,048,089 on Nov. 1, 2011, and PCT Application No. PCT/US2014/024992, filed on Mar. 12, 2014 and published as WO 2014/151104 on Sep. 25, 2014, the entireties of both of which are hereby incorporated by reference herein. 
     The systems, apparatuses, devices and/or other articles disclosed herein may be formed through any suitable means. The various methods and techniques described above provide a number of ways to carry out the inventions. Of course, it is to be understood that not necessarily all objectives or advantages described may be achieved in accordance with any particular embodiment described herein. Thus, for example, those skilled in the art will recognize that the methods may be performed in a manner that achieves or optimizes one advantage or group of advantages as taught herein without necessarily achieving other objectives or advantages as may be taught or suggested herein. 
     Although several embodiments and examples are disclosed herein, the present application extends beyond the specifically disclosed embodiments to other alternative embodiments and/or uses of the inventions and modifications and equivalents thereof. It is also contemplated that various combinations or subcombinations of the specific features and aspects of the embodiments may be made and still fall within the scope of the inventions. Accordingly, it should be understood that various features and aspects of the disclosed embodiments can be combine with or substituted for one another in order to form varying modes of the disclosed inventions. Thus, it is intended that the scope of the present inventions herein disclosed should not be limited by the particular disclosed embodiments described above, but should be determined only by a fair reading of the claims that follow. 
     While the embodiments disclosed herein are susceptible to various modifications, and alternative forms, specific examples thereof have been shown in the drawings and are herein described in detail. It should be understood, however, that the inventions are not to be limited to the particular forms or methods disclosed, but, to the contrary, the inventions are to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the various embodiments described and the appended claims. Any methods disclosed herein need not be performed in the order recited. The methods disclosed herein include certain actions taken by a practitioner; however, they can also include any third-party instruction of those actions, either expressly or by implication. For example, actions such as “providing” include “instructing providing.” The ranges disclosed herein also encompass any and all overlap, sub-ranges, and combinations thereof. Language such as “up to,” “at least,” “greater than,” “less than,” “between,” and the like includes the number recited. Numbers preceded by a term such as “about” or “approximately” include the recited numbers. For example, “about 10 mm” includes “10 mm.” Terms or phrases preceded by a term such as “substantially” include the recited term or phrase. For example, “substantially parallel” includes “parallel.”