Patent Publication Number: US-6339044-B1

Title: N-P-Cyanoaryl nitrogen-containing heterocycles having pendent sulfur-containing groups

Description:
This is a continuation of application Ser. No. 08/656,293, filed on Jun. 13, 1996, now abandoned, which is a 371 of PCT/EP94/04070 filed on Dec. 7, 1994. 
    
    
     The invention relates to novel N-cyanoaryl nitrogen heterocycles having sulphur-containing groupings, a plurality of processes for their preparation and their use as herbicides and insecticides. 
     It is already known that certain N-cyanoaryl nitrogen heterocycles have herbicidal properties (cf. WO-A 91/00278, WO-A 92/11244, EP-A 408382, EP-A 438209, EP-A 473551, DE-A 4237920). However, the herbicidal action and the compatibility of the previously known N-cyanoaryl nitrogen heterocycles with cultivated plants are not entirely satisfactory. 
     The novel N-cyanoaryl nitrogen heterocycles having sulphur-containing groupings of the general formula (I) have now been found,                    
     in which 
     Q 1  represents oxygen or sulphur, 
     R 1  represents hydrogen or halogen, 
     R 2  represents halogen, cyano, nitro, amino or the grouping —N(A 1 )SO 2 A, in which 
     A represents, in each case, optionally substituted alkyl, alkenyl, alkinyl, dialkylamino, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, and 
     A 1  represents hydrogen, formyl or, in each case optionally substituted, alkyl, alkenyl, alkinyl, alkylcarbonyl, alkoxycarbonyl or alkylsulphonyl, or 
     together with A represents alkanediyl, 
     R 3  represents hydrogen, halogen, cyano or optionally substituted alkyl, 
     R 4  represents optionally substituted alkyl or together with R 3  represents alkanediyl, and 
     Z represents one of the groupings below                    
      in which 
     Q 2  represents oxygen or sulphur and 
     R 5  represents hydrogen or, in each case optionally substituted, alkyl, alkenyl, alkinyl or alkylcarbonyl, 
     and salts of compounds of the formula (I) 
     with the proviso that at least one of the groupings Q 1  or Q 2  represents sulphur. 
     The general formula (I) therefore represents the isomeric compounds of the general formulae (IA) and (IB) below                    
     The novel N-cyanoaryl nitrogen heterocycles having sulphur-containing groupings of the general formula (I) are obtained if 
     (a) aminoalkenoic (thio)esters of the general formula (II)                    
      in which 
     Q 1 , R 3 , R 4  and R 5  have the meanings given above and 
     R represents alkyl, 
     are reacted with cyanoaryl iso(thio)cyanates of the general formula (III)                    
      in which 
     Q 2 , R 1  and R 2  have the meanings given above, 
     in the presence or absence of a reaction auxiliary and in the presence or absence of a diluent, 
     or if 
     (b) for the preparation of compounds of the formulae (IA) and/or (IB) in which R 5  represents, in each case optionally substituted, alky, alkenyl or alkinyl and Q 1 , Q 2 , R 1 , R 2 , R 3  and R 4  have the meanings given above, 
     N-cyanoaryl nitrogen heterocycles of the general formula (IA) or (IB) 
     in which R 5  represents hydrogen and Q 1 , Q 2 , R 1 , R 2 , R 3  and R 4  have the meanings given above, 
     are reacted with alkylating agents of the general formula (IV) or (V) 
     
       
         X—R 5   (IV) 
       
     
     
       
         R 5 —O—SO 2 —O—R 5   (V) 
       
     
     in which R 5  represents, in each case optionally substituted, alkyl, alkenyl or alkinyl, 
     in the presence or absence of an acid acceptor and in the presence or absence of a diluent, 
     or if 
     (c) for the preparation of compounds of the formula (I) in which R 2  represents amino or the grouping —N(A 1 )SO 2 A and A, A 1 , Q 1 , Q 2 , R 1 , R 3 , R 4  and Z have the meanings given above, 
     N-cyanoaryl nitrogen heterocycles of the general formula (I), in which R 2  represents halogen and Q 1 , Q 2 , R 1 , R 3 , R 4  and Z have the meanings given above, 
     are reacted with ammonia or with amides of the general formula (VI) 
     
       
         HN(A 1 )SO 2 A  (VI) 
       
     
     in which 
     A and A 1  have the meanings given above, 
     in the presence or absence of an acid acceptor and in the presence or absence of a diluent. 
     The compounds of the formula (I) can, by analogy with process (a), also be obtained by reaction of aminoalkenoic (thio)esters of the formula (II)—above—with cyanoaryl (thio)urethanes of the formula (IIIa)                    
     in which 
     Q 2 , R 1  and R 2  have the meanings given above and 
     R represents alkyl (in particular methyl) or aryl (in particular phenyl). 
     The novel N-cyanoaryl nitrogen heterocycles having sulphur-containing groupings of the general formula (I) are distinguished by high herbicidal efficiency. 
     In the definitions, the saturated or unsaturated hydrocarbon chains, such as alkyl, alkanediyl, alkenyl or alkinyl, are each straight-chain or branched. 
     Halogen generally represents fluorine, chlorine, bromine or iodine, preferably fluorine, chlorine or bromine, in particular fluorine or chlorine. 
     The invention preferably relates to compounds of the formula (I) in which 
     Q 1  represents oxygen or sulphur, 
     R 1  represents hydrogen, fluorine, chlorine or bromine, 
     R 2  represents fluorine, chlorine, bromine, cyano, nitro, amino or the grouping —N(A 1 )SO 2 A, in which 
     A represents a radical selected from the group consisting of alkyl, alkenyl, alkinyl or dialkylamino each having up to 10 carbon atoms and each of which is optionally substituted by fluorine, chlorine, bromine, cyano or C 1 -C 4 -alkoxy, 
     A further represents cycloalkyl or cycloalkylalkyl, each of which is optionally substituted by fluorine, chlorine, bromine, cyano or C 1 -C 4 -alkyl, having 3 to 8 carbon atoms in the cycloalkyl moiety and, if appropriate, 1 to 4 carbon atoms in the alkyl moiety, 
     A further represents aryl or arylalkyl, each of which is optionally substituted by fluorine, chlorine, bromine, cyano, nitro, carboxy, carbamoyl, by C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkylthio, C 1 -C 4 -alkylsulphinyl or C 1 -C 4 -alkylsulphonyl (which are each optionally substituted by fluorine and/or chlorine), by dimethylaminosulphonyl or diethylaminosulphonyl, by C 1 -C 4 -alkoxy-carbonyl (which is optionally substituted by fluorine, chlorine, bromine, methoxy or ethoxy), by phenyl or phenyloxy (which are each optionally substituted by fluorine, chlorine, bromine, cyano, methyl, methoxy, trifluoromethyl and/or trifluoromethoxy), having 6 or 10 carbon atoms in the aryl moiety and, if appropriate, 1 to 4 carbon atoms in the alkyl moiety, and 
     A 1  represents hydrogen or formyl, or C 1 -C 4 -alkyl which is optionally substituted by fluorine and/or chlorine, cyano or C 1 -C 4 -alkoxy-carbonyl, or C 1 -C 4 -alkyl-carbonyl or C 1 -C 4 -alkoxy-carbonyl, each of which is optionally substituted by fluorine, chlorine or C 1 -C 4 -alkoxy, or C 1 -C 4 -alkylsulphonyl which is optionally substituted by fluorine and/or chlorine, or 
     together with A represents alkanediyl having 2 to 8 carbon atoms, 
     R 3  represents hydrogen, fluorine, chlorine, bromine, cyano or alkyl, which is optionally substituted by fluorine and/or chlorine, having 1 to 4 carbon atoms, 
     R 4  represents alkyl, which is optionally substituted by fluorine, chlorine, bromine, methoxy or ethoxy, having 1 to 6 carbon atoms, 
     or together with R 3  represents alkanediyl having 2 to 8 carbon atoms, and 
     Z represents one of the groupings below                    
      in which 
     Q 2  represents oxygen or sulphur and 
     R 5  represents hydrogen or alkyl, alkenyl, alkinyl or alkylcarbonyl, each of which is optionally substituted by fluorine, chlorine, bromine, cyano, C 1 -C 4 -alkoxy, C 1 -C 4 -alkyl-carbonyl or C 1 -C 4 -alkoxy-carbonyl, and each of which has up to 6 carbon atoms, 
     with the proviso that at least one of the groupings Q 1  or Q 2  represents sulphur. 
     The invention further preferably relates to sodium salts, potassium salts, calcium salts, ammonium salts, C 1 -C 4 -alkyl-ammonium salts, di-(C 1 -C 4 -alkyl)-ammonium salts, tri-(C 1 -C 4 -alkyl)-ammonium salts, cyclopentyl- or cyclohexyl-ammonium salts and di-(C 1 -C 4 -alkyl)-ammonium salts of compounds of the formula (I) in which Q 1 , R 1 , R 2 , R 3 , R 4  and Z have the meaning given above as preferred. 
     The invention relates in particular to compounds of the formula (I) in which 
     Q 1  represents oxygen or sulphur, 
     R 1  represents hydrogen, fluorine or chlorine, 
     R 2  represents fluorine, chlorine, bromine, cyano, amino or the grouping —N(A 1 )SO 2 A, in which 
     A represents a radical selected from the group consisting of methyl, ethyl, n- or i-propyl, n-, i-, s- or t-butyl, ethenyl, propenyl, butenyl, each of which is optionally substituted by fluorine or chlorine, or represents dimethylamino, 
     A further represents cyclopropyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopentylmethyl or cyclohexylmethyl, each of which is optionally substituted by fluorine, chlorine, bromine, methyl and/or ethyl, 
     A further represents phenyl, naphthyl, phenylmethyl or phenylethyl, each of which is optionally substituted by fluorine, chlorine, bromine, cyano, nitro, carboxy, methyl, trifluoromethyl, methoxy, ethoxy, difluoromethoxy, trifluoromethoxy, methylthio, ethylthio, methylsulphinyl, ethylsulphinyl, methylsulphonyl, ethylsulphonyl, dimethylaminosulphonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl or phenyl, and 
     A 1  represents hydrogen, formyl, methyl, ethyl, acetyl, propionyl, methoxycarbonyl, ethoxycarbonyl, methylsulphonyl or ethylsulphonyl, or together with A represents trimethylene or tetramethylene, 
     R 3  represents hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, ethyl, n- or i-propyl, 
     R 4  represents methyl, ethyl, n- or i-propyl, each of which is optionally substituted by fluorine or chlorine, or together with R 3  represents trimethylene or tetramethylene, and 
     Z represents one of the groupings below                    
      in which 
     Q 2  represents oxygen or sulphur and 
     R 5  represents hydrogen, methyl, difluoromethyl, cyanomethyl, ethyl, fluoroethyl, chloroethyl, difluoroethyl, dichloroethyl, trifluoroethyl, chlorodifluoroethyl, cyanoethyl, n- or i-propyl, fluoropropyl, chloropropyl, cyanopropyl, allyl, chloroallyl, propargyl, acetyl, propionyl, fluoroacetyl, chloroacetyl, difluoroacetyl, dichloroacetyl, trifluoroacetyl or trichloroacetyl, 
     with the proviso that at least one of the groupings Q 1  or Q 2  represents sulphur. 
     A very particularly preferred group of compounds of the formula (I) are the compounds of the formula (IA) in which Q 1  represents oxygen, Q 2  represents sulphur, and R 1 , R 2 , R 3 , R 4  and R 5  have the meaning given above as preferred in particular. 
     A further very particularly preferred group of compounds of the formula (I) are the compounds of the formula (IB) in which Q 1  represents oxygen, Q 2  represents sulphur, and R 1 , R 2 , R 3 , R 4  and R 4  have the meaning given above as preferred in particular. 
     The general radical definitions or the radical definitions given in preferred areas listed above apply not only to the end products of the formula (I) but also correspondingly to each of the starting materials or intermediates necessary for preparation. These radical definitions can be combined in any manner with one another, that is also between the given ranges of preferred compounds. 
     Examples of the compounds of the invention of the formula (IA)—where in each case Q 1  represents oxygen and Q 2  represents sulphur—are listed in Table 1 below. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Examples of the compounds of the formula (IA) 
               
            
           
           
               
               
               
               
               
            
               
                 R 1   
                 R 2   
                 R 3   
                 R 4   
                 R 5   
               
               
                   
               
               
                 F 
                 F 
                 H 
                 CH 3   
                 H 
               
               
                 F 
                 F 
                 H 
                 CH 3   
                 CH 3   
               
               
                 F 
                 F 
                 H 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CH 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 F 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 F 
                 H 
                 CF 3   
                 C 3 H 7   
               
               
                 Cl 
                 F 
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CF 3   
                 CH 2 —C≡CH 
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 F 
                 H 
                 CF 2 CF 3   
                 H 
               
               
                 F 
                 F 
                 H 
                 CF 2 CF 3   
                 CH 3   
               
               
                 H 
                 F 
                 H 
                 CF 2 CF 3   
                 C 2 H 5   
               
               
                 H 
                 F 
                 H 
                 CF 2 CF 3   
                 CH 2 CH═CH 2   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CF 2 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 2 CF 3   
                 CH 3   
               
               
                 F 
                 F 
                 H 
                 CHF 2   
                 H 
               
               
                 F 
                 F 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 F 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 Cl 
                 CHF 2   
                 CH 2 CH═CH 2   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 CH 3   
                 CH 3   
               
               
                 F 
                 N(K)SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 N(Na)SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 N(K)SO 2 C 2 H 5   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 N(Na)SO 2 C 2 H 5   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CF 3   
                 H 
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 2 CF 3   
                 CH 3   
               
               
                 F 
                 F 
                 H 
                 CHF 2   
                 H 
               
               
                 F 
                 F 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 F 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 Cl 
                 CHF 2   
                 CH 2 CH═CH 2   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 CH 3   
                 CH 3   
               
               
                 F 
                 N(K)SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 N(Na)SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 N(K)SO 2 C 2 H 5   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 N(Na)SO 2 C 2 H 5   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CF 3   
                 H 
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 3   
                 H 
                 CH 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 2 H 5   
                 H 
                 CH 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CH 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CH 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CH 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CH 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 6 H 5   
                 H 
                 CH 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CH 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CH 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CH 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CH 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CH 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CH 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CH 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 6 H 5   
                 H 
                 CH 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CH 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 6 H 5   
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 6 H 5   
                 H 
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 CH 3   
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 6 H 5   
                 CH 3   
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 Cl 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 Cl 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 Cl 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 Cl 
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 Cl 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 6 H 5   
                 Cl 
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 F 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 F 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 F 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 F 
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 F 
                 CH 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 6 H 5   
                 F 
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CH 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CH 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CH 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CH 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CH 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CH 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CH 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 6 H 5   
                 H 
                 CH 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CH 3   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 CF 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 3   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 CF 3   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 3   
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 CF 3   
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 CH 2 CF 3   
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -sec 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -iso 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 5 H 11 -n 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 F 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 F 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 F 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 F 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 F 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 F 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 F 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 F 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 F 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CF 3   
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 3   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 CF 3   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 2 H 5   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CEIF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 13   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 3   
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 CF 3   
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 2 H 5   
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 5 H 10 -n 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 R 
                 CHF 2   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 3   
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 CF 3   
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 CH 2 CF 3   
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -sec 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -iso 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 5 H 11 -n 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 F 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 F 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 F 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 F 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 F 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 F 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 F 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 F 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 F 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CF 3   
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CHF 2   
                 CHF 2   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 3   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 CF 3   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 2 H 5   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 CH 2 CF 3   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 3   
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 CF 3   
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 2 H 5   
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 CH 2 CF 3   
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 3   
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 CF 3   
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 CH 2 CF 3   
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -sec 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -iso 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 H 
                 NHSO 2 C 5 H 11 -n 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CR3 
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                 P 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 CH 3   
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CF 3   
                 CH 3   
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 CH 3   
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 CH 3   
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 CH 3   
                 C 2 F 5   
                 CHF 2    
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 CH 3   
                 C 2 F 5   
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 CH 3   
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 C 2 F 5   
                 CHF 2   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 3   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 CF 3   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 3   
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 CF 3   
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 F 
                 NHSO 2C   5 H 11 -n 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 3   
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 CF 3   
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 CH 2 CF 3   
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -sec 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 4 H 9 -iso 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 H 
                 NHSO 2 C 5 H 11 -n 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 CF 3   
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 F 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 CF 3   
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 3   
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 CF 3   
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 2 H 5   
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 CH 2 CF 3   
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -n 
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 3 H 7 -i 
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 NHSO 2 CH 2 CH 2 CH 2 Cl 
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -n 
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -sec 
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 4 H 9 -iso 
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                 F 
                 NHSO 2 C 5 H 11 -n 
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 2 Cl 
                 CHF 2   
               
               
                   
               
               
                 H 
                 —N(SO 2 CH 3 ) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 —N(SO 2 CH 3 )(SO 2 C 2 H 5)   
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 —N(SO 2 C 2 H 5 ) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 —N(SO 2 CH 3 )(SO 2 C 3 H 7 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 —N(SO 2 C 3 H 7 ) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 —N(SO 2 CH 3 )(SO 2 C 3 H 7 -i) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 —N(SO 2 C 3 H 7 -i) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 ) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 ) 2   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 2 H 5 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 2 H 5 ) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 3 H 7 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 3 H 7 ) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 3 H 7 -i) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 3 H 7 -i) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 2 H 5 )(SO 2 C 3 H 7 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 4 H 9 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 4 H 9 ) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 CF 3 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CF 3 ) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 CH 2 CF 3 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 2 CF 3 ) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 3 H 6 Cl) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 2 CH 2 CH 2 Cl) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 6 H 5 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 6 H 5 ) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 2 H 5 )(SO 2 C 6 H 5 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 —N(SO 2 CH 3 ) 2   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 ) 2   
                 H 
                 CHF 2   
                 C 2 H 5   
               
               
                 F 
                 —N(SO 2 C 2 H 5 ) 2   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 3 H 7 ) 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 3 H 7 ) 2   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 3 H 7 -i) 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 3 H 7 -i) 2   
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 4 H 9 ) 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 4 H 9 ) 2   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 CF 3 ) 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CF 3 ) 2   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 CH 2 CF 3 ) 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 2 CF 3 ) 2   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 6 H 5 ) 
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 6 H 5 ) 2   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 2 H 5 )(SO 2 C 6 H 5 ) 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CHF 2   
                 CH 3   
               
               
                   
               
               
                 F 
                 —N(SO 2 CH 3 ) 2   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 ) 2   
                 H 
                 CF 2 Cl 
                 C 2 H 5   
               
               
                 F 
                 —N(SO 2 C 2 H 5 ) 2   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 3 H 7 ) 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 3 H 7 ) 2   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 3 H 7 -i) 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 3 H 7 -i) 2   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 4 H 9 ) 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 4 H 9 ) 2   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 CF 3 ) 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 —N(SO 2 CF 3 ) 2   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 CH 2 CF 3 ) 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 2 CF 3 ) 2   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 2 CH 2 CH 2 Cl) 2   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 6 H 5 ) 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 6 H 5 ) 2   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                   
               
               
                 F 
                 —N(SO 2 CH 3 ) 2   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 ) 2   
                 H 
                 C 2 F 5   
                 C 2 H 5   
               
               
                 F 
                 —N(SO 2 C 2 H 5 ) 2   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 3 H 7 ) 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 3 H 7 ) 2   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 3 H 7 -i) 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 3 H 7 -i) 2   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 4 H 9 ) 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 4 H 9 ) 2   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 CF 3 ) 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CF 3 ) 2   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 2 CF 3 ) 2   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 6 H 5 ) 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 6 H 5 ) 2   
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 C 2 F 5   
                 CH 3   
               
               
                   
               
               
                 F 
                 —N(SO 2 CH 3 ) 2   
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 ) 2   
                 CH 3   
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 —N(SO 2 C 2 H 5 ) 2   
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 ) 2   
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 ) 2   
                 Cl 
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 —N(SO 2 CH 3 )(SO 2 C 2 H 5 ) 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 C 2 H 5 ) 2   
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(COOCH 3 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(COOC 2 H 5 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(COOC 4 H 9 -t) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(COOC 6 H 5 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(COCH 3 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(COCF 3 ) 
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 —N(SO 2 CH 3 )(CHO) 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CHF 2   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 H 
                 NHSO 2 CH═CH 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH═CH 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 CH═CH 2   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 CH═CH 2   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 CH═CH 2   
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 CH═CH 2   
                 CH 3   
                 CF 3   
                 CHF 2   
               
               
                 H 
                 NHSO 2 N(CH 3 ) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 N(CH 3 ) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 H 
                 NHSO 2 N(CH 3 ) 2   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 F 
                 NHSO 2 N(CH 3 ) 2   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 H 
                 NHSO 2 N(CH 3 ) 2   
                 Cl 
                 CF 3   
                 CH 3   
               
               
                 F 
                 NHSO 2 N(CH 3 ) 2   
                 CH 3   
                 CF 3   
                 CH 3   
               
               
                   
               
            
           
         
       
     
     If, for example, methyl 3-aminocrotonate and 4-cyano-2,5-difluoro-phenyl isothio-cyanate are used as starting materials, the course of the reaction in the process (a) of the invention can be outlined by the following formula scheme:                    
     If, for example, 1-(3-chloro-4-cyano-phenyl)-3,6-dihydro-6-oxo-2-thioxo-4-trifluoro-methyl-1(2H)-pyrimidine and methyl bromide are used as starting materials, the course of the reaction in the process (b) of the invention can be outlined by the following formula scheme:                    
     If, for example, 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-3,4-dimethyl-2-oxo-6-thioxo-1(2H)-pyrimidine and ethanesulphonamide are used as starting materials, the course of the reaction in the process (c) of the invention can be outlined by the following formula scheme:                    
     The aminoalkenoic (thio)esters to be used as starting materials for the preparation of compounds of the formula (I) in the process (a) of the invention are generally defined by the formula (II). 
     In formula (II), Q 1 , R 3  and R 4  preferably or in particular have that meaning which has already been given above in connection with the description of the compounds of the invention of the formula (I) as preferred or preferred in particular for Q 1 , R 3  and R 4 ; 
     R preferably represents C 1 -C 4 -alkyl, in particular methyl or ethyl. 
     The starting materials of the formula (II) are known and/or can be prepared by known processes (cf J. Heterocycl. Chem. 9 (1972), 513-522). 
     The cyanoaryl iso(thio)cyanates further to be used as starting materials in the process (a) of the invention are generally defined by the formula (III). 
     In formula (III), Q 2 , R 1  and R 2  preferably or in particular have those meanings which have already been given above in connection with the description of the compounds of the invention of the formula (I) as preferred or preferred in particular for Q 2 , R 1  and R 2 . 
     The starting materials of the formula (III) are known and/or can be prepared by known processes (cf. J. Org. Chem. 30 (1965), 2465-2466; cf. also DE-P 4327743 and DE-P 4335438). 
     The cyanoaryl iso(thio)cyanates of the formula (III) are obtained if corresponding cyanoarylamines of the general formula (VII)                    
     in which 
     R 1  and R 2  have the meaning given above, 
     are reacted with phosgene or thiophosgene, in the presence or absence of a reaction auxiliary, such as calcium carbonate, and in the presence or absence of diluents, such as methylene chloride, toluene, chlorobenzene and, if appropriate, water, at temperatures between 0° C. and 150° C. (cf. the preparation examples). 
     The process (a) of the invention for the preparation of the novel compounds of the formula (I) is preferably carried out using diluents. The diluents which are suitable here are virtually all inert organic solvents. These preferably include aliphatic and aromatic, nonhalogenated or halogenated hydrocarbons such as pentane, hexane, heptane, cyclohexane, petroleum ether, benzine, ligroin, benzene, toluene, xylene, methylene chloride, ethylene chloride, chloroform, tetrachloromethane, chlorobenzene and o-dichloro-benzene, ethers, such as diethyl ether and dibutyl ether, glycol dimethyl ether and di-glycol dimethyl ether, tetrahydrofuran and dioxane, ketones such as acetone, methyl ethyl ketone, methyl isopropyl ketone and methyl isobutyl ketone, esters such as methyl acetate and ethyl acetate, nitriles such as acetonitrile and propionitrile, amides such as dimethylformamide, dimethylacetamide and N-methylpyrrolidone and dimethyl sulphoxide, tetramethylene sulphone and hexamethylphosphoric triamide. 
     The process (a) of the invention is preferably carried out in the presence of a reaction auxiliary. Reaction auxiliaries which are suitable here are principally acid acceptors. Preferably, those which are used are alkali metal hydrides and alkaline earth metal hydrides, such as lithium hydride, sodium hydride, potassium hydride and calcium hydride, alkali metal hydroxides and alkaline earth metal hydroxides, such as lithium hydroxide, sodium hydroxide, potassium hydroxide and calcium hydroxide, alkali metal carbonates and hydrogen carbonates and alkaline earth metal carbonates and hydrogen carbonates, such as sodium carbonate or hydrogen carbonate and potassium carbonate or hydrogen carbonate and calcium carbonate, alkali metal acetates, such as sodium acetate and potassium acetate, alkali metal alkoxides, such as sodium methoxide, ethoxide, propoxide, isopropoxide, butoxide, isobutoxide and tert-butoxide and potassium methoxide, ethoxide, propoxide, isopropoxide, butoxide, isobutoxide and tert-butoxide, in addition basic nitrogen compounds, such as trimethylamine, triethylamine, tripropylamine, tributylamine, diisobutylamine, dicyclohexylamine, ethyldiisopropylamine, ethyldicyclohexylamine, N,N-dimethylbenzylamine, N,N-dimethyl-aniline, pyridine, 2-methyl-, 3-methyl-, 4-methyl-, 2,4-dimethyl-, 2,6-dimethyl-, 2-ethyl-, 4-ethyl- and 5-ethyl-2-methyl-pyridine, 1,5-diazabicyclo[4,3,0]-non-5-ene (DBN), 1,8-diazabicyclo-[5,4,0]-undec-7-ene (DBU) and 1,4-diazabicyclo-[2,2,2]-octane (DABCO). 
     The reaction temperatures can be varied in a relatively wide range in the process (a) of the invention. Generally, temperatures between −120° C. and +100° C. are employed, preferably temperatures between −70° C. and +80° C. 
     The process (a) of the invention is generally carried out at atmospheric pressure. However, it is also possible to employ elevated or reduced pressure. 
     To carry out the process (a) of the invention, the starting materials needed in each case are generally used in approximately equimolar amounts. However, it is also possible to employ one of the two components used in each case in a relatively great excess. The reactions are generally carried out in a suitable diluent in the presence of a reaction auxiliary, and the reaction mixture is stirred for a plurality of hours at the temperature required in each case. The workup in the process (a) of the invention is performed in each case by conventional methods (cf. the preparation examples). 
     The N-cyanoaryl nitrogen heterocycles to be used as starting materials for the preparation of compounds of the formula (I) in the process (b) of the invention are generally defined by the formulae (IA) and (IB)—with the proviso that R 5  represents hydrogen therein. 
     In the formulae (IA) and (IB), Q 1 , Q 2 , R 1 , R 2 , R 3  and R 4  preferably or in particular have those meanings which have already been given above in connection with the description of the compounds of the invention of the formula (I) as preferred or preferred in particular for Q 1 , Q 2 , R 1 , R 2 , R 3  and R 4 . 
     The starting materials of the formulae (IA) and (B) for process (b) are novel compounds of the invention, they can be prepared by the process (a) of the invention. 
     The alkylating agents further to be used as starting materials in the process (b) of the invention are generally defined by the formulae (IV) and (V). 
     In the formulae (IV) and (V), R 5  preferably or in particular has that meaning which has already been given above in connection with the description of the compounds of the invention of the formula (I) as preferred or preferred in particular for R 5 . 
     The starting materials of the formulae (IV) and (V) are known organic synthesis chemicals. 
     The process (b) of the invention is preferably carried out using a diluent. Those diluents are suitable here, principally, which have already been mentioned in the description of the process (a) of the invention. 
     Acid acceptors which can be used in the process (b) of the invention are all acid binders which are conventionally usable for such reactions. Preferably, those which can be used are alkali metal hydrides and alkaline earth metal hydrides, such as lithium hydride, sodium hydride, potassium hydride and calcium hydride, alkali metal hydroxides and alkaline earth metal hydroxides, such as lithium hydroxide, sodium hydroxide, potassium hydroxide and calcium hydroxide, alkali metal carbonates and hydrogen carbonates and alkaline earth metal carbonates and hydrogen carbonates, such as sodium carbonate or hydrogen carbonate and potassium carbonate or hydrogen carbonate and calcium carbonate, alkali metal acetates, such as sodium acetate and potassium acetate, alkali metal alkoxides, such as sodium methoxide, ethoxide, propoxide, isopropoxide, butoxide, isobutoxide and tert-butoxide and potassium methoxide, ethoxide, propoxide, isopropoxide, butoxide, isobutoxide and tert-butoxide, in addition basic nitrogen compounds, such as trimethylamine, triethylamine, tripropylamine, tributylamine, diisobutylamine, dicyclohexylamine, ethyldiisopropylamine, ethyldicyclohexylamine, N,N-dimethylbenzylamine, N,N-dimethyl-aniline, pyridine, 2-methyl-, 3-methyl-, 4-methyl-, 2,4-dimethyl-, 2,6-dimethyl-, 2-ethyl-, 4-ethyl- and 5-ethyl-2-methyl-pyridine, 1,5-diazabicyclo[4,3,0]-non-5-ene (DBN), 1,8-diazabicyclo-[5,4,0]-undec-7-ene (DBU) and 1,4-diazabicyclo-[2,2,2]-octane (DABCO). 
     The reaction temperatures in the process (b) of the invention can be varied within a relatively wide range. Generally, temperatures between 0° C. and 120° C. are employed, preferably temperatures between 10° C. and 100° C. 
     The process (b) of the invention is generally carried out at atmospheric pressure. However, it is also possible to employ elevated or reduced pressure. 
     To carry out the process (b) of the invention, the starting materials needed in each case are generally used in approximately equimolar amounts. However, it is also possible to employ one of the two components used in each case in a relatively great excess. The reactions are generally carried out in a suitable diluent in the presence of an acid acceptor, and the reaction mixture is stirred for a plurality of hours at the temperature required in each case. The workup in the process (b) of the invention is carried out in each case by conventional methods (cf. the preparation examples). 
     The N-cyanoaryl nitrogen heterocycles to be used as starting materials for the preparation of compounds of the formula (I) in the process (c) of the invention are generally defined by the formula (I)—with the proviso that R 2  represents halogen therein. 
     In formula (I), Q 1 , Q 2 , R 1 , R 3 , R 4  and Z preferably or in particular then have those meanings which have already been given above as preferred or as preferred in particular for Q 1 , Q 2 , R 1 , R 3 , R 4  and Z in connection with the description of the compounds of the formula (I) of the invention. 
     The starting materials of the formula (I) for process (c) are novel compounds of the invention; they can be prepared by the processes (a) and (b) of the invention. 
     The amides further to be used as starting materials in the process (c) of the invention are generally defined by the formula (VI). 
     In formula (VI), A and A 1  preferably or in particular have that meaning which has already been given above as preferred or preferred in particular for A and A 1  in connection with the description of the compounds of the formula (I) of the invention. 
     The starting materials of the formula (VI) are known organic synthesis chemicals. 
     The process (c) of the invention is preferably carried out using a diluent. Those diluents which are suitable here are principally those which have already been mentioned in the description of the process (a) of the invention. 
     The process (c) of the invention is carried out in the presence or absence of an acid acceptor. Those acid acceptors are suitable here which have already been mentioned in the description of the process (b) of the invention. 
     The reaction temperatures in the process (c) of the invention can be varied in a relatively broad range. Generally, temperatures between 0° C. and 200° C. are employed, preferably temperatures between 20° C. and 180° C. 
     The process (c) of the invention is generally carried out at atmospheric pressure. However, it is also possible to employ elevated or reduced pressure. 
     To carry out the process (c) of the invention, the starting materials required in each case are generally used in approximately equimolar amounts. However, it is also possible to employ one of two components used in each case in a relatively great excess. The reactions are generally carried out in a suitable diluent in the presence of an acid acceptor, and the reaction mixture is stirred for a plurality of hours at the temperature required in each case. The workup in the process (c) of the invention is performed in each case by conventional methods (cf. the preparation examples). 
     The active compounds of the invention can be used as defoliants, desiccants, herbicides and, in particular, as weed killers. Weeds in the broadest sense are taken to mean all plants which grow at places where they are not desired. Whether the substances of the invention act as total or selective herbicides essentially depends on the application rate. 
     The active compounds of the invention can be used, eg., in the case of the following plants: 
     Dicotyledonous weeds of the genera: Sinapis, Lepidium, Galium, Stellaria, Matricaria, Anthemis, Galinsoga, Chenopodium, Urtica, Senecio, Amaranthus, Portulaca, Xanthium, Convolvulus, Ipomoea, Polygonum, Sesbania, Ambrosia, Cirsium, Carduus, Sonchus, Solanum, Rorippa, Rotala, Lindernia, Lamium, Veronica, Abutilon, Emex, Datura, Viola, Galeopsis, Papaver, Centaurea, Trifolium, Panunculus and Taraxacum. 
     Dicotyledonous cultivated plants of the genera: Gossypium, Glycine, Beta, Daucus, Phaseolus, Pisum, Solanum, Linum, Ipomoca, Vicia, Nicotiana, Lycopersicon, Arachis, Brassica, Lactuca, Cucumis and Cucurbita. 
     Monocotyledonous weeds of the genera: Echinochloa, Setaria, Panicum, Digitaria, Phleum, Poa, Festuca, Eleusine, Brachiaria, Lolium, Bromus, Avena, Cyperus, Sorghum, Agropyron, Cynodon, Monochoria, Fimbristylis, Sagittaria, Eleocharis, Scirpus, Paspalum, Ischaemum, Sphenoclea, Dactyloctenium, Agrostis, Alopecurus and Apera. 
     Monocotyledonous cultivated plants of the genera: Oryza, Zea, Triticum, Hordeum, Avena, Secale, Sorghum, Panicum, Saccharum, Ananas, Asparagus and Allium. 
     However, the use of the active compounds of the invention is in no way restricted to these genera, but also extends in a similar manner to other plants. 
     The compounds, depending on the concentration, are suitable for total weed control, eg. on industrial areas and railway tracks and on paths and grounds with or without tree growth. Likewise, the compounds can be used for weed control in permanent cultivation, eg. forest, ornamental wood plantations, fruit cultivation, vineyards, citrus plantations, nut plantations, banana plantations, coffee plantations, tea plantations, rubber plantations, oil palm plantations, cocoa plantations, berry fruit plantations and hopfields, on ornamental lawns and sports fields and grazing areas and for selective weed control in annual cultivations. 
     The compounds of the formula (I) of the invention are suitable, in particular, for the selective control of monocotyledonous and dicotyledonous weeds in monocotyledonous and dicotyledonous cultivations both in the preemergence and postemergence methods. 
     The active compounds are also suitable for controlling animal pests, preferably arthropods and nematodes, in particular insects and arachnids, which occur in agriculture, in forestry, in the protection of stored products and materials and in the hygiene sector. They are active against species of usual sensitivity and resistance and against all or individual development stages. The pests mentioned above include: 
     From the order of the Isopoda, eg.  Oniscus asellus, Armadillidium vulgare  and  Porcellio scaber.    
     From the order of the Diplopoda, eg.  Blaniulus guttulatus.    
     From the order of the Chilopoda, eg.  Geophilus carpophagus  and Scutigera spec. 
     From the order of the Symphyla, eg.  Scutigerella immaculata.    
     From the order of the Thysanura, eg.  Lepisma saccharina.    
     From the order of the Collembola, eg.  Onychiurus armatus.    
     From the order of the Orthoptera, eg.  Blatta orientalis, Periplaneta americana, Leucophaea maderae, Blattella germanica, Acheta domesticus,  Gryllotalpa spp.,  Locusta migratoria migratorioides, Melanoplus differentialis  and  Schistocerca gregaria.    
     From the order of the Dermaptera, eg.  Forficula auricularia.    
     From the order of the Isoptera, eg. Reticulitermes spp. 
     From the order of the Anoplura, eg.  Phylloxera vastatrix,  Pemphigus spp.,  Pediculus humanus corporis,  Haematopinus spp. and Linognathus spp. 
     From the order of the Mallophaga, eg. Trichodectes spp. and Damalinea spp. 
     From the order of the Thysanoptera, eg.  Hercinothrips femoralis  and  Thrips tabaci.    
     From the order of the Heteroptera, eg. Eurygaster spp.,  Dysdercus intermedius, Piesma quadrata, Cimex lectularius, Rhodnius prolixus  and Triatoma spp. 
     From the order of the Homoptera, eg.  Aleurodes brassicae, Bemisia tabaci, Trialeurodes vaporariorum, Aphis gossypii, Brevicoryne brassicae, Cryptomyzus ribis, Aphis fabae, Doralis pomi, Eriosoma lanigerum, Hyalopterus arundinis, Macrosiphum avenae,  Myzus spp.,  Phorodon humuli, Rhopalosiphum padi,  Empoasca spp.,  Euscelis bilobatus, Nephotettix cincticeps, Lecanium corni, Saissetia oleae, Laodelphax striatellus, Nilaparvata lugens, Aonidiella aurantii, Aspidiotus hederae,  Pseudococcus spp. and Psylla spp. 
     From the order of the Lepidoptera, eg.  Pectinophora gossypiella, Bupalus piniarius, Cheimatobia brumata, Lithocolletis blancardella, Hyponomeuta padella, Plutella maculipennis, Malacosoma neustria, Euproctis chrysorrhoea,  Lymantria spp.,  Bucculatrix thurberiella, Phyllocnistis citrella,  Agrotis spp., Euxoa spp., Feltia spp.,  Earias insulana,  Heliothis spp.,  Spodoptera exigua, Mamestra brassicae, Panolis flammea, Prodenia litura,  Spodoptera spp.,  Trichoplusia ni, Caprocapsa pomonella,  Pieris spp., Chilo spp.,  Pyrausta nubilalis, Ephestia kuehniella, Galleria mellonella, Tineola bisselliella, Tinea pellionella, Hofmannophila pseudospretella, Cacoecia podana, Capua reticulana, Choristoneura fumiferana, Clysia ambiguella, Homona magnanima  and  Tortrix viridana.    
     From the order of the Coleoptera, eg.  Anobium punctatum, Rhizopertha dominica, Acanthoscelides obtectus, Bruchidius obtectus, Hylotrupes bajulus, Agelastica alni, Leptinotarsa decemlineata, Phaedon cochleariae,  Diabrotica spp.,  Psylliodes chrysocephala, Epilachna varivestis,  Atomaria spp.,  Oryzaephilus surinamensis,  Anthonomus spp., Sitophilus spp.,  Otiorrhynchus sulcatus, Cosmopolites sordidus, Ceuthorrhynchus assimilis, Hypera postica,  Dermestes spp., Trogoderma spp., Anthrenus spp., Attagenus spp., Lyctus spp.,  Meligethes aeneus,  Ptinus spp.,  Niptus hololeucus, Gibbium psylloides,  Tribolium spp.,  Tenebrio molitor,  Agriotes spp., Conoderus spp.,  Melolontha melolontha, Amphimallon solstitialis  and  Costelytra zealandica.    
     From the order of the Hymenoptera, eg. Diprion spp., Hoplocampa spp., Lasius spp.,  Monomorium pharaonis  and Vespa spp. 
     From the order of the Diptera, eg. Aedes spp., Anopheles spp., Culex spp.,  Drosophila melanogaster,  Musca spp., Fannia spp.,  Calliphora erythrocephala,  Lucilia spp., Chrysomyia spp., Cuterebra spp., Gastrophilus spp., Hyppobosca spp., Stomoxys spp., Oestrus spp., Hypoderma spp., Tabanus spp., Tannia spp.,  Bibio hortulanus, Oscinella frit,  Phorbia spp.,  Pegomyia hyoscyami, Ceratitis capitata, Dacus oleae  and  Tipula paludosa.    
     From the order of the Siphonaptera, eg.  Xenopsylla cheopis  and Ceratophyllus spp. 
     From the order of the Arachnida, eg.  Scorpio maurus  and  Latrodectus mactans.    
     From the order of the Acarina, eg.  Acarus siro,  Argas spp., Ornithodoros spp.,  Dermanyssus gallinae, Eriophyes ribis, Phyllocoptruta oleivora,  Boophilus spp., Rhipicephalus spp., Amblyomma spp., Hyalomma spp., Ixodes spp., Psoroptes spp., Chorioptes spp., Sarcoptes spp., Tarsonemus spp.,  Bryobia praetiosa,  Panonychus spp. and Tetranychus spp. 
     The phytopathogenic nematodes include Pratylenchus spp.,  Radopholus similis, Ditylenchus dipsaci, Tylenchulus semipenetrans,  Heterodera spp., Meloidogyne spp., Aphelenchoides spp., Longidorus spp., Xiphinema spp. and Trichodorus spp. 
     The active compounds can be converted into the conventional formulations, such as solutions, emulsions, wettable powders, suspensions, powders, dusts, pastes, soluble powders, granules, suspension/emulsion concentrates, natural and synthetic materials impregnated with active compound and very fine encapsulations in polymeric materials. 
     These formulations are prepared in a known manner, eg. by mixing the active compounds with extenders, that is liquid solvents and/or solid carriers, with or without the use of surfactants, that is emulsifiers and/or dispersants and/or foam-forming agents. 
     In the case of the use of water as extender, eg. organic solvents can also be used as solubilizer. Liquid solvents which are suitable are essentially: aromatics, such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons, such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons, such as cyclohexane or paraffins, eg. mineral oil fractions, mineral and vegetable oils, alcohols such as butanol or glycol and their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, highly polar solvents, such as dimethylformamide and dimethyl sulphoxide, and water. 
     Solid carriers which are useful are: 
     eg. ammonium salts and natural rock flours, such as kaolins, clays, talcum, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth and synthetic rock flours, such as highly disperse silica, aluminium oxide and silicates; solid carriers for granules which are suitable are: eg. crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite, dolomite and synthetic granules of inorganic and organic flours and granules from organic material such as sawdust, coconut shells, corn cobs and tobacco stalks; emulsifiers and/or foam-forming agents which are suitable are: eg. nonionogenic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxythylene fatty alcohol ethers, eg. alkylaryl polyglycol ethers, alkylsulphonates, alkyl-sulphates, arylsulphonates and protein hydrolysates; dispersants which are suitable are: eg. lignin sulphite liquors and methylcellulose. 
     In the formulations, binding agents such as carboxymethylcellulose, natural and synthetic pulverulent, granular or latex-like polymers, can be used, such as gum arabic, poly(vinyl alcohol), poly(vinyl acetate), and natural phospholipids, such as cephalins and lecithins and synthetic phospholipids. Other additives can be mineral and vegetable oils. 
     Colourants can be used, such as inorganic pigments, eg. iron oxide, titanium oxide, Prussian Blue and organic colourants, such as alizarin, azo and metallophthalocyanine colourants and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc. 
     The formulations generally contain between 0.1 and 95% by weight of active compound, preferably between 0.5 and 90%. 
     The active compounds of the invention can also be used as such or in their formulations in a mixture with known herbicides for weed control, ready-to-use formulations or tank mixtures being possible. 
     Known herbicides are suitable for the mixtures, for example anilides such as diflufenican and propanil; arylcarboxylic acids such as dichloropicolinic acid, dicamba and picloram; aryloxyalkanoic acids such as 2,4 D, 2,4 DB, 2,4 DP, fluroxypyr, MCPA, MCPP and triclopyr; aryloxy-phenoxy-alkanoic esters such as diclofop-methyl, fenoxaprop-ethyl, fluazifop-butyl, haloxyfop-methyl and quizalofop-ethyl; azinones such as chloridazon and norflurazon; carbamates such as chlorpropham, desmedipham, phen-medipham and propham; chloroacetanilides such as alachlor, acetochlor, butachlor, metazachlor, metolachlor, pretilachlor and propachlor; dinitroanilines such as oryzalin, pendimethalin and trifluralin; diphenyl ethers such as acifluorfen, bifenox, fluoro-glycofen, fomesafen, halosafen, lactofen and oxyfluorfen; ureas such as chlortoluron, diuron, fluometuron, isoproturon, linuron and methabenzthiazuron; hydroxylamines such as alloxydim, clethodim, cycloxydim, sethoxydim and tralkoxydim; imidazolinones such as imazethapyr, imazamethabenz, imazapyr and imazaquin; nitriles such as bromoxynil, dichlobenil and ioxynil; oxyacetamides such as mefenacet; sulphonylureas such as amidosulfuron, bensulfuron-methyl, chlorimuron-ethyl, chlorsulfuron, cinosulfuron, met-sulfuron-methyl, nicosulfuron, primisulfuron, pyrazosulfuron-ethyl, thifensulfuron-methyl, triasulfuron and tribenuron-methyl; thiolcarbamates such as butylate, cycloate, diallate, EPTC, esprocarb, molinate, prosulfocarb, thiobencarb and triallate; triazines such as atrazine, cyanazine, simazine, simetryne, terbutryne and terbuthylazine; triazinones such as hexazinone, metamitron and metribuzin; others such as aminotriazole, benfuresate, bentazone, cinmethylin, clomazone, clopyralid, difenzoquat, dithiopyr, ethofumesate, fluorochloridone, glufosinate, glyphosate, isoxaben, pyridate, quinclorac, quinmerac, sulphosate and tridiphane. 
     A mixture with other known active compounds, such as fungicides, insecticides, acaricides, nematicides, bird repellants, plant nutrients and soil structure improvers is also possible. 
     The active compounds can be applied as such, in the form of their formulations or the application forms prepared therefrom by further dilution, such as ready-to-use solutions, suspensions, emulsions, powders, pastes and granules. They are applied in a conventional manner, eg. by pouring, sprinkling, spraying, scattering. 
     The active compounds of the invention can be applied either before or after the emergence of plants. They can also be incorporated into the soil before sowing. 
     The active compound application rate can vary in a relatively broad range. It essentially depends on the type of effect desired. Generally, the application rates are between 10 g and 10 kg of active compound per hectare of soil surface, preferably between 50 g and 5 kg per ha. 
    
    
     The preparation and use of the active compounds of the invention follow from the examples below. 
     PREPARATION EXAMPLES 
     Example 1 
     
       
         
         
             
             
         
       
     
     1.8 g (10 mmol) of ethyl 3-amino-4,4,4-trifluoro-crotonate are introduced into 30 ml of dimethylformamide and 2 ml of toluene and 0.4 g (10 mmol) of sodium hydride (80% strength) are added at 0° C. to +5° C. The mixture is stirred at the temperature specified for 30 minutes. After cooling to −70° C., 1.0 g (5 mmol) of 4-cyano-2,5-difluoro-phenyl isothiocyanate are added and the reaction mixture is stirred for 2 hours at −70° C., then for a further 15 hours at +20° C. and finally for 4 hours at +50° C. 2 ml of acetic acid are then added to the mixture, it is diluted with water to about twice the volume and extracted with ethyl acetate. The organic phase is concentrated and the crude product remaining as residue is purified by column chromatography (silica gel; initial run with methylene chloride discarded; main fraction with ethyl acetate). The main fraction eluted is concentrated and the residue is brought to crystallization by digestion with diethyl ether. 
     0.3 g (9% of theory) of 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2-thioxo-6-oxo-4-trifluoromethyl-1(2H)-pyrimidine are obtained of melting point 187° C. 
     Example 2 
     
       
         
         
             
             
         
       
     
     0.9 g (2.7 mmol) of 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2-thioxo-6-oxo-4-trifluoromethyl-1(2H)-pyrimidine and 0.37 g (2.7 mmol) of potassium carbonate are introduced into 10 ml of acetone and 0.38 g (2.7 mmol) of methyl iodide is added at −10° C. The reaction mixture is stirred for 15 hours at +20° C. and then filtered. The solvent is carefully distilled off from the filtrate in a water-jet vacuum. 
     1.0 g (approximately 100% of theory) of 1-(4-cyano-2,5-difluoro-phenyl)-1,6-dihydro-2-methylthio-6-oxo-4-trifluoromethyl-pyrimidine are obtained as oily residue. 
       1 H-NMR (dimethyl sulphoxide D 6 , δ): 7.02 ppm. 
     Example 3 
     
       
         
         
             
             
         
       
     
     9.9 g (50 mmol) of ethyl 3-methylamino-4,4,4-trifluoro-crotonate are introduced into 100 ml of dimethylformamide and 10 ml of toluene and 2.0 g (50 mmol) of sodium hydride (60% strength) are added at −15° C. The mixture is stirred at the temperature specified for 15 minutes, then 5.0 g (25 mmol) of 4-cyano-2,5-difluorophenyl isothiocyanate are added and the mixture is stirred for 15 hours at 20° C. 
     6 ml of acetic acid are then added; the mixture is diluted to about twice the volume with water and extracted with ethyl acetate. The organic phase is concentrated and the crude product remaining as residue is purified by column chromatography (silica gel; methylene chloride). The main fraction eluted is concentrated and the residue is brought to crystallization by digestion with diisopropyl ether. 
     1.1 g (13% oftheory) of 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2-thioxo-6-oxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidine are obtained of melting point 191° C. 
     Example 4 
     
       
         
         
             
             
         
       
     
     2.1 g (10.5 mmol) of ethyl 3-methylamino-4,4,4-trifluoro-crotonate are introduced into 50 ml of dimethylformamide and 5 ml of toluene and 0.4 g (10.9 mmol) of sodium hydride (60% strength) is added at −70° C. The mixture is stirred at the temperature specified for 15 minutes and then 2.0 g (7 mmol) of 4-cyano-2-fluoro-5-ethylsulphonylamino-phenyl isothiocyanate are added. The reaction mixture is then stirred for 4 hours at −60° C., and 6 ml of acetic acid are then added and the mixture is diluted with water to about twice the volume. The organic phase is separated off and concentrated. The residue is brought to crystallization by digestion with diisopropyl ether. 
     0.7 g (25% of theory) of 1-(4-cyano-2-fluoro-5-ethylsulphonylamino-phenyl)-3,6-dihydro-2-thio-6-oxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidine is obtained of melting point 150° C. 
     Analogously to the Examples 1 to 4 and in accordance with the general description of the preparation methods of the invention, the compounds of the formula (I)—or of the formula (IA) or (IB)—listed in Table 2 below can also be prepared, for example.                    
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Examples of the compounds of the formula (I) 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 Ex. 
                 General 
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 formula 
                 Q 1   
                 Q 2   
                 R 1   
                 R 2   
                 R 3    
                 R 4   
                 R 5   
                 point (° C.) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 5 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 C 3 H 7   
                 H 
                 CF 3   
                 CH 3   
                 162 
               
               
                 6 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 CH 3   
                 H 
                 CF 3   
                 H 
               
               
                 7 
                 IB 
                 O 
                 S 
                 F 
                 —NHSO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 8 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 214 
               
               
                 9 
                 IB 
                 O 
                 S 
                 F 
                 —N(CH 3 )SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 10 
                 IB 
                 O 
                 S 
                 F 
                 —NHSO 2 C 2 H 5   
                 H 
                 CF 3   
                 CH 3   
               
               
                 11 
                 IB 
                 O 
                 S 
                 F 
                 —NHSO 2 CH 3   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 12 
                 IB 
                 O 
                 S 
                 F 
                 —NHSO 2 C 2 H 5   
                 H 
                 CF 3   
                 C 3 H 7   
               
               
                 13 
                 IB 
                 O 
                 S 
                 F 
                 —NHSO 2 C 3 H 7   
                 H 
                 CF 3   
                 CHF 2   
               
               
                 14 
                 IB 
                 O 
                 S 
                 F 
                 —NHSO 2 CH(CH 3 ) 2   
                 H 
                 CF 3   
                 CH 3   
               
               
                 15 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 CH(CH 3 ) 2   
                 H 
                 CF 3   
                 CH 3   
                 114 
               
               
                 16 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 CH 3   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 17 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 CH 3   
                 H 
                 CF 3   
                 C 3 H 7   
               
               
                 18 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 C 2 H 5   
                 H 
                 CF 3   
                 CHF 2   
               
               
                 19 
                 IA 
                 O 
                 S 
                 F 
                 —N(C 2 H 5 )SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 20 
                 IA 
                 O 
                 S 
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
                 208 
               
               
                   
               
               
                 21 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 C 4 H 9   
                 H 
                 CF 3   
                 CH 3   
                 161 
               
               
                   
               
               
                 22 
                 IA 
                 O 
                 S 
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 23 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 CH 3   
                 H 
                 CHF 2   
                 CH 3   
               
               
                 24 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 CH 3   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 25 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 C 2 H 5   
                 H 
                 CF 2 Cl 
                 CH 3   
               
               
                 26 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 C 2 H 5   
                 H 
                 CF 3   
                 C 2 H 5   
               
               
                 27 
                 IA 
                 O 
                 S 
                 H 
                 —NHSO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 28 
                 IA 
                 O 
                 S 
                 H 
                 —NHSO 2 C 2 H 5   
                 H 
                 CF 3   
                 CH 3   
               
               
                   
               
               
                 29 
                 IA 
                 O 
                 S 
                 Cl 
                 —NHSO 2 CH 3   
                 H 
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 30 
                 IA 
                 O 
                 S 
                 Cl 
                 —NHSO 2 C 3 H 7   
                 H 
                 CF 3   
                 CH 3   
               
               
                 31 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 C 2 H 5   
                 H 
                 CF 3   
                 C 2 H 5   
                 177 
               
               
                   
               
               
                 32 
                 IA 
                 O 
                 S 
                 F 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 CH 3   
                 122 
               
               
                   
               
               
                 33 
                 IA 
                 O 
                 S 
                 F 
                 —N(CH 3 )SO 2 C 2 H 5   
                 H 
                 CF 3   
                 CH 3   
                 68 
               
               
                 34 
                 IA 
                 O 
                 S 
                 F 
                 —N(CH 3 )SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
               
               
                 35 
                 IA 
                 O 
                 S 
                 F 
                 —NHSO 2 CH 3   
                 H 
                 CHF 2   
                 CH 3   
                 220 
               
               
                   
               
            
           
         
       
     
     The compound listed in Table 2 as Example 32 can be prepared, for example, as follows:                    
     A mixture of 2.0 g (4.4 mmol) of 1-(4-cyano-2-fluoro-5-ethylsulphonylamino-phenyl)-3,6-dihydro-2-thio-6-oxo-3-methyl-4-trifluoromethyl- 1(2H)-pyrimidine, 0.64 g (5.6 mmol) of methanesulphonyl chloride, 0.8 g (8 mmol) of triethylamine and 50 ml of acetonitrile is stirred for 15 hours at 20° C. and then the mixture is concentrated in a water-jet vacuum. The residue is stirred with water and the product produced in the crystalline state is isolated by filtration. 
     2.3 g (100% of theory) of 1-(4-cyano-2-fluoro-5-(N-ethylsulphonyl-N-methylsulphonyl-amino)-phenyl)-3,6-dihydro-2-thio-6-oxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidine are obtained of melting point 122° C. 
     The compound listed in Table 2 as Example 33 can be prepared, for example, as follows:                    
     A mixture of 1.5 g (3.4 mmol) of 1-(4-cyano-2-fluoro-5-ethylsulphonylamino-phenyl)-3,6-dihydro-2-thio-6-oxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidine, 0.5 g (3.8 mmol) of potassium carbonate and 30 ml of acetonitrile is stirred for 30 minutes at 20° C. and then 0.5 g (3.8 mmol) of dimethyl sulphate is added. The reaction mixture is then refluxed for 5 hours and stirred for a further 60 hours at 20° C. The mixture is then concentrated in a water-jet vacuum, the residue is stirred with water and the product produced in the crystalline state is isolated by filtration. 
     1.2 g (78% of theory) of 1-(4-cyano-2-fluoro-5-(N-ethylsulphonyl-N-methyl-amino)-phenyl)-3,6-dihydro-2-thio-6-oxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidine are obtained of melting point 68° C. 
     Starting Materials of the Formula (III) 
     Example (III-1) 
     
       
         
         
             
             
         
       
     
     10.0 g (65 mmol) of 4-cyano-2,5-difluoro-aniline are introduced into 100 ml of toluene and 8.2 g (71 mmol) of thiophosgene are slowly added to the mixture heated to 80° C. to 90° C. The reaction mixture is then refluxed for approximately 40 hours. Then, after the solvent has been carefully distilled off under reduced pressure, the product (4-cyano-2,5-difluoro-phenyl isothiocyanate) is obtained as an ochre colourant. 
       1 H-NMR (CDCl 3 , δ): 7.03 ppm. 
     Application Examples 
     Example A 
     Pre-emergence Test 
     
       
         
           
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Solvent: 
                 5 parts by weight of acetone 
               
               
                   
                 Emulsifier: 
                 1 part by weight of alkylaryl polyglycol ether 
               
               
                   
                   
               
            
           
         
       
     
     To prepare an expedient active compound preparation, 1 part by weight of active compound is mixed with the specified amount of solvent, the specified amount of emulsifier is added and the concentrate is diluted with water to the desired concentration. 
     Seeds of the test plants are sown in standard soil and are watered after 24 hours with the active compound preparation. The amount of water per unit area is expediently kept constant during this. The active compound concentration in the preparation is not important, only the application rate of the active compound per unit area is critical. After three weeks, the degree of damage of the plants is evaluated in % damage in comparison with the development of the untreated control. In the evaluation: 
     0% denotes no effect (as untreated control) 
     100% denotes total destruction 
     In this test, the compounds, for example, according to the Preparation Examples 3, 4, 7 and 8 display, with good compatibility with cultivated plants, such as wheat (0%), high activity against weeds such as Abutilon (80-100%), Amaranthus (70-100%), Ambrosia (95-100%), Galinsoga (90-100%), Portulaca (90-100%) and Solanum (80-100%) at an application rate of 60 g per hectare. 
     Example B 
     Post-emergence Test 
     
       
         
           
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Solvent: 
                 5 parts by weight of acetone 
               
               
                   
                 Emulsifier: 
                 1 part by weight of alkylaryl polyglycol ether 
               
               
                   
                   
               
            
           
         
       
     
     To prepare an expedient active compound preparation, 1 part by weight of active compound is mixed with the specified amount of solvent, the specified amount of emulsifier is added and the concentrate is diluted with water to the desired concentration. 
     Test plants which have a height of 5-15 cm are sprayed with the active compound preparation in such a way that the amounts of active compound per unit area desired in each case are applied. After three weeks, the degree of damage of the plants is evaluated in % damage in comparison with the development of the untreated control. 
     In the evaluation: 
     0% denotes no effect (as untreated control) 
     100% denotes total destruction 
     In this test, the compounds, for example, according to the Preparation Examples 3, 4 and 8 display, with very good compatibility with cultivated plants, such as wheat (5%), without exception, high activity against weeds such as Abutilon (100%), Chenopodium (100%), Ipomoea (100%), Solanum (100%) and Veronica (100%), at an application rate of only 30 g per hectare. 
     Example C 
     Phaedon Larvae Test 
     Solvent: 7 parts by weight of dimethylformamide 
     Emulsifier: 1 part by weight of alkylaryl polyglycol ether 
     To produce an expedient active compound preparation, 1 part by weight of active compound is mixed with the specified amount of solvent and the specified amount of emulsifier and the concentrate is diluted with water to the desired concentration. 
     Cabbage leaves ( Brassica oleracea ) are treated by dipping them into the active compound preparation of the desired concentration and populated with horseradish leaf beetle larvae  Phaedon cochleariae,  as long as the leaves are still moist. 
     After the desired time, the destruction is determined in %. In the determination, 100% denotes that all beetle larvae have been destroyed; 0% denotes that no beetle larvae have been destroyed. 
     In this test the compound, for example, according to Preparation Example 3 displays a degree of destruction of 100% after 3 days at an active compound concentration of 0.1%.