Patent Publication Number: US-2023148646-A1

Title: Anti-viral, anti-microbial and stimulating immunity food supplement

Description:
FIELD OF THE INVENTION 
     This invention relates to an anti-viral, anti-microbial and stimulating immunity food supplement, which will find application both in preventive health care and to improve the body&#39;s immune defenses. 
     BACKGROUND OF THE INVENTION 
     The human body has many protective barriers that protect us from pathogens. Their entry into it is hampered by various obstacles that our body has created—sneezing, coughing, saliva, skin, stomach acid and others. After the pathogens overcoming these protective barriers, the immune system is included in the defense. The human immune system has to deal with many stressors on a daily basis. It can be weakened by diseases, toxins, air pollution, unhealthy foods and beverages, stress, aging and even physical exertion. In addition, the immune system changes throughout our lives, at every stage of it, depending on age, lifestyle, eating habits and exercise. With overall weakening of the body, pathogens much easier overcome non-specific barriers of protection and penetrate it. People whose immune systems do not work optimally have more infections each year and it takes longer to recover. That is why it is necessary to strengthen the immune system in a timely manner. 
     Immunostimulants aim to increase the body&#39;s defenses and have a role in the treatment of pre-existing infections. With their help the period of illness is shortened, recovery after viral and bacterial infections is facilitated. 
     Technical essence of the utility model. The task of the utility model is to create an anti-viral, anti-microbial and stimulating immunity food supplement, which will support the functions of the immune system to increase the body&#39;s defenses. 
     The problem was solved by creating a food supplement to stimulate immunity, which includes the following components in weight percentages: liquorice— Glycyrrhiza glabra  from 1.19% to 47.61%, sweet wormwood— Artemisia annua  from 1.19% to 47.61%, quinine bark extract— Cinho  from 1.19% to 47.61%, hawthorn extract— Crataegus  from 1.19% to 47.61%, dandelion extract— Taraxcum  from 1.19% to 47.61%, Vitamin C—Ascorbic acid from 1.19% to 47.61%, DD-Galacturonic acid from 1.19% to 47.61%, apple pectin from 1.19% to 47.61%, bitter orange— Citrus aurantium  from 1.19% to 47.61%, ginger— Zingiber officinale  from 0.23% to 11.9%,  Radix isatidis  from 0.23% to 11.9%,  Lindera aggregate  from 0.23% to 11.9%, woad—Isatis indigotica from 0.23% to 9.52%, Torreya nucifera from 0.23% to 9.52%, geranium extract— Pelargonium  from 0.23% to 9.52%, Zinc from 0.23% to 2.38% and Sodium Selenite from 0.00119% to 0.04762%. 
     In a preferred embodiment of the food supplement, liquorice— Glycyrrhiza glabra  is 11.91%, sweet wormwood— Artemisia annua  is 11.91%, quinine bark extract— Cinho  is 11.91%, hawthorn extract— Crataegus  is 9.52%, Dandelion extract— Taraxcum  is 9.52%, vitamin C—Ascorbic acid is 9.52%, DD-Galacturonic acid is 9.52%, apple pectin is 9.52%, bitter orange— Citrus aurantium  is 4.76%, ginger— Zingiber officinale  is 2.38%,  Radix Isatidis  is 2.38%,  Lindera aggregate  is 2.38%, woad— Isatis indigotica  is 1.19%,  Torreya nucifera  is 1.19%, geranium extract— Pelargonium  is 1.19%, Zinc is 1.19% and Sodium Selenite is 0.01%. 
     The advantage of the created food supplement is that it has anti-inflammatory, antimicrobial and immunomodulatory effect, acts against the penetration of external pathogens into the cell, maintains the functions of the immune system and increases the body&#39;s defenses. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     The developed nutritional supplement to stimulate immunity, in a preferred embodiment, includes the following components in weight percent: liquorice— Glycyrrhiza glabra  11.91%, sweet wormwood— Artemisia annua  11.91%, quinine bark extract— Cinho  11.91%, hawthorn extract— Crataegus  9.52%, dandelion extract— Taraxcum  9.52%, vitamin C—Ascorbic acid 9.52%, DD-Galacturonic acid 9.52%, apple pectin 9.52%, bitter orange— Citrus aurantium  4.76%, ginger— Zingiber officinale  2.38%,  Radix Isatidis  2.38%,  Lindera aggregate  2.38%, woad— Isatis indigotica  1.19%,  Torreya nucifera  1.19%, geranium extract— Pelargonium  1.19%, Zinc 1.19% and Sodium Selenite 0.01%. 
     Liquorice ( Glycyrrhiza glabra ) has a long history of use in the treatment of coughs and colds, as well as for the regulation of indigestion.  Ammonium glycyrrhizinate , which is the active substance in liquorice, has an anti-inflammatory effect and is used to treat the damage caused by hepatitis B to the liver. In combination with vitamin C it also shows anti-viral action against various flu and other viruses. 
     Sweet wormwood ( Artemisia annua ) has anti-inflammatory and immunomodulatory effect and prevents the penetration of foreign pathogens into the cell. The quinine contained in the quinine tree extract ( Cinho ) alkalizes cell membranes, thus inhibiting viral replication. 
     Hawthorn extract ( Crataegus ) protects the cardiovascular system by taking care of the condition of the heart muscle, supports normal heart rhythm and has a beneficial effect on peripheral, coronary and cerebral blood vessels. 
     Dandelion extract ( Taraxcum ) has a proven anti-viral effect by inhibiting the entry of viruses into host cells by inhibiting key viral enzymes. 
     Vitamin C (Ascorbic acid) is a vitamin with a strong antioxidant and immunostimulant effect. D-D-Galacturonic acid helps lower serum cholesterol and triglycerides. In addition, it improves the digestive system, helps regulate body weight and blood sugar and strengthens the immune system. 
     Apple pectin helps lower serum cholesterol and triglycerides. Improves the digestive system, helps regulate body weight and blood sugar and strengthens the immune system. Bitter orange ( Citrus aurantium ) has a proven antifungal effect, helps regulate body weight and thus strengthens the immune system. 
     Ginger ( Zingiber officinale ) is considered an effective remedy against nausea, diarrhea, colic and other stomach problems, as well as a painkiller for rheumatic diseases and menstrual pain. Strengthens the immune system.  Radix isatidis  is an extract of the dried root of the plant  Isatis tinctorial  L, known for its immunostimulating, anti-infective and anti-inflammatory properties. The plant is widely used in traditional Chinese medicine to stimulate the body&#39;s immune system, fight bacterial and viral infections and accelerate recovery after illness. 
       Lindera aggregate  has a proven anti-viral effect.  Isatis indigotica  has a proven antibacterial, antiviral and anti-inflammatory effect.  Torreya nucifera  has a proven antiviral effect. Geranium extract ( Pelargonium ) has a proven antiviral effect by inhibiting the entry of viruses into host cells and also by inhibiting key viral enzymes. 
     Zinc increases resistance to infections and has antiviral activity. Sodium Selenite is involved in the formation of selenoenzymes with antioxidant action. Reduces oxidative stress and increases immunity. 
     The created food supplement to stimulate immunity is produced as follows: All components are in powder form. They are pre-tested for moisture content, which should be no more than 5-6%, and a microbial analysis is performed. The mixing is performed in reverse order of the percentage input, ie. it starts from the component with the lowest weight percentage to a higher one. In this case, sodium selenite is combined with zinc, then woad, Thorium Nucifera and geranium extract are added. Mixing is carried out in a turbulent mixer at 18° C. and humidity of 28-31%. 
     The next group of low-percentage ingredients is added sequentially under the same conditions—bitter orange, ginger,  Radix Isatidis  and  Linder Aggregate , and so on until the end, when higher percentage ingredients are added to the mix. 
     Binders such as microcrystalline cellulose, stearate, silica, etc. are added to the finished mixture. The final mixture is mixed under the same conditions for about 30-40 minutes, then sealed in dry containers under pressure of dry nitrogen and provided in portions for dosing to capsule dispensers. The ready dosed capsules are stored at a temperature of about 18-20° C. until packed in blisters. 
     The whole process is carried out in a microbially clean environment, according to GMP practice. The finished blister product is submitted for packaging, marking and shipping.