Patent Publication Number: US-10761088-B2

Title: Method for identifying histone tail proteolysis

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application claims priority under 35 U.S.C. § 119(e) to U.S. Provisional Application No. 62/308,100, filed Mar. 14, 2016, the contents of which is hereby incorporated by reference into the present disclosure. 
    
    
     STATEMENT OF GOVERNMENT SUPPORT 
     This invention was made with government support under Grant No. R01GM084209 awarded by National Institutes of Health (NIH). The government has certain rights in the invention. 
    
    
     SEQUENCE LISTING 
     The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on May 11, 2017, is named 064189-7551_SL.txt and is 15,462 bytes in size. 
     TECHNICAL FIELD 
     This invention embodies methods and kits related to epigenomics and medicine. In particular the invention is related to methods of identifying cleaved histones and treatment of bone conditions. 
     BACKGROUND 
     This disclosure references various publications, patents and published patent specifications by an identifying citation. The full citations for the disclosures are found immediately preceding the claims. The disclosures of these publications, patents and published patent specifications and all referenced documents are hereby incorporated by reference into the present disclosure in their entirety to more fully describe the state of the art to which this invention pertains. 
     The basic components that comprise the canonical nucleosome core particle are evolutionarily conserved in all eukaryotes. Within a living cell, however, there exists a remarkable degree of heterogeneity in nucleosome composition that influences chromatin structure and function (Luger et al. 2012). This is exemplified by the various covalent posttranslational modifications (PTMs) of the N-terminal tails (NT) of the core histone proteins (H3, H4, H2A, H2B) that alter nucleosome composition to regulate fundamental DNA-templated programs such as transcription (Zentner and Henikoff 2013). For example, acetylation of the H3NT can directly facilitate transcription by destabilizing nucleosome structure whereas methylation of the H3NT can indirectly regulate transcription by binding effector proteins that stimulate or repress transcription (Bannister et al. 2001; Shogren-Knaak et al. 2006). Recent landmark reports determined that differences in the “epigenomic signatures” of several H3NT PTMs are strongly correlated to the cell type-specific gene expression programs observed in &gt;250 normal and diseased human tissues (Polak et al. 2015; Roadmap Epigenomics et al. 2015). These studies demonstrate that precise alterations of the epigenome are essential in the regulation of gene pathways necessary for the derivation of normal and aberrant cell types. 
     Altering epigenomic signatures by “erasing” H3NT PTMs can be achieved by several different enzymatic mechanisms. One mechanism is the selective removal of specific H3 PTMs by histone-modifying enzymes such as deacetylases and demethylases (Black et al. 2012; Seto and Yoshida 2014). A more extreme mechanism involves ATP-dependent deposition of a new H3 resulting in the removal of all pre-existing PTMs and associated interacting proteins (Narlikar et al. 2013). An alternative intermediate mechanism between the specific and complete erasure of H3 PTMs is proteolysis of the H3NT, which selectively removes pre-existing H3NT PTMs and associated interacting proteins without affecting the H3 core region (Azad and Tomar 2014; Dhaenens et al. 2015). While retention of the H3 core region preserves nucleosome structure, lack of the H3NT destabilizes intra- and inter-nucleosomal interactions that may increase DNA accessibility and facilitate factor binding (Allan et al. 1982; Andresen et al. 2013; Nurse et al. 2013). Therefore, H3NT cleavage provides an efficient means to rapidly and drastically alter chromatin structure and function both directly and indirectly. 
     Although proteolysis of histones within chromatin was first reported over 55 years ago, the mechanisms and biological functions of histone cleavage remain largely unknown (Phillips and Johns 1959). Proteolysis of the H3NT has been detected in various single and multi-cellular eukaryotes indicating that H3NT cleavage is an evolutionarily conserved process that likely functions in epigenetic regulation (Allis et al. 1980; Bortvin and Winston 1996; Duncan et al. 2008; Pauli et al. 2010; Duarte et al. 2014; Vossaert et al. 2014). Consistent with this, H3NT cleavage is frequently observed during mammalian developmental programs including embryonic stem cell differentiation, mammary gland development and myogenesis (Duncan et al. 2008; Asp et al. 2011; Khalkhali-Ellis et al. 2014; Vossaert et al. 2014). The recent identification of Cathepsin L and D as the principal H3NT protease during mouse embryonic stem cell differentiation and mammary gland development, respectively, suggests that precursor cells utilize different H3NT proteases in a differentiation-dependent context (Duncan et al. 2008; Khalkhali-Ellis et al. 2014). While these reports imply that targeted H3NT proteolysis at specific genomic regions facilitates differentiation, the lack of a method to identify H3NT-cleaved regions has precluded significant insights into the mechanistic functions of H3NT proteolysis. Thus, a need exists in the art and this disclosure satisfies this need and provides related advantages as well. 
     SUMMARY 
     In this disclosure Applicant demonstrates that matrix metalloproteinase 9 (MMP-9) is the principal H3NT protease of osteoclastogenesis. Applicant also developed the first method to map H3NT-cleaved regions in mammals, called “ChIP of acetylated chromatin (ChIPac).” Applicant further demonstrates the selective targeting of MMP-dependent H3NT proteolysis near transcription start sites of osteoclastogenic genes during differentiation. Consistent with H3NT cleavage-dependent gene activation reported in  S. cerevisiae , Applicant discovered that H3NT proteolysis was strongly correlated with transcriptional activation (Santos-Rosa et al. 2009). Abrogation of MMP-9-dependent H3NT proteolysis resulted in impaired osteoclastogenic gene activation and defective osteoclast differentiation. Therefore, the results reported herein support a model whereby MMP-9-dependent H3NT proteolysis at osteoclastogenic genes facilitates their activation necessary for proficient osteoclast differentiation. 
     The DNA in eukaryotic cells is hierarchically packaged by histones to form a highly repressive structure of chromatin. The basic unit of chromatin is the nucleosome, which consists of 147 bp of DNA wrapped around an H3-H4 tetramer and a pair of H2A-H2B dimers. Recent reports suggest that the dynamic modification of chromatin architecture plays fundamental roles in regulating specific gene expression programs. Chromatin architecture can be altered by several different enzymatic mechanisms. One mechanism is the removal of the N-terminal tail domain of histone H3 proteins by specific proteases. This mechanism selectively removes pre-existing H3 tail modifications and associated interacting proteins without affecting the H3 core regions. Thus, it is necessary to determine the genomic sites targeted for H3 N-terminal tail proteolysis to investigate the role of H3 tail cleavage in transcriptional regulation. Mapping these cleavage sites could be achieved by Chromatin Immunoprecipitation sequencing (ChIP-seq) analysis, but an antibody that has specific affinity for the H3 N-terminal tail of all H3 proteins, is not dependent on or inhibited by existing H3 posttranslational modifications and is validated for Chromatin Immunoprecipitation (ChIP) applications, is not available. 
     To overcome this technical barrier, Applicant developed a novel method, called ChIP of acetylated chromatin (ChIPac), for identification and examination of genetic loci bound by H3 with N-terminal tail-cleaved regions. The antibody recognizing H3 lysine 14 acetylation (H3K14ac) satisfies the criteria above for ChIP of the H3 N-terminal tail following complete lysine acetylation of crosslinked chromatin in vitro by acetic anhydride. First, cells were fixed with methylene blue to crosslink chromatin after brief exposure to white light. It should be noted that most ChIP protocols utilize formaldehyde to crosslink proteins to DNA in vivo. However, because formaldehyde reacts with lysine ε-amino side-chains, which likely precludes complete lysine acetylation by acetic anhydride, methylene blue was used as an alternative for cell fixation. Chromatin was isolated and the efficiency of crosslinking was confirmed by sodium dodecyl sulfate-chloroformisoamyl alcohol (SDS-CIA). Fragmented chromatin was then treated with acetic anhydride to completely acetylate all unmodified lysine residues in vitro. ChIPac using an H3K14ac-specific antibody selectively enriched H3 N-terminal tail-containing chromatin and simultaneously excluded chromatin lacking the H3 N-terminal tail. ChIPac using an H3 C-terminal tail antibody was performed in parallel as the normalization control. H3 N-terminal tail-cleaved regions were identified by the significant reduction in H3K14ac enrichment relative to control as determined by quantitative PCR (qPCR) or NextGen sequencing analysis. 
     Thus, in one aspect, provided herein is a method to identify and examine H3 N-terminal tail cleaved regions of a histone, the method comprising, or alternatively consisting essentially of, or yet further consisting of: a) contacting a cell containing chromatin with methylene blue or an equivalent thereof after exposure to white light or an equivalent of the white light to crosslink proteins in the cell; b) isolating the chromatin, c) acetylating all unmodified lysine residues by contacting the chromatin with acetic anhydride; d) conducing ChIPac with an H3 C-terminal tail antibody; and e) identifying H3 N-terminal tail-cleaved regions by detecting reduction in H3K14ac enrichment relative to a control. 
     In some aspects of the method, step e. is performed by a method comprising, or alternatively consisting essentially of, or yet further consisting of, quantitative PCR (qPCR) or NextGen sequencing analysis. 
     In another aspect, provided herein is a method to identify a polynucleotide fragment bound to an H3 histone comprising a cleaved N-terminal tail (H3NT) in a cell, the method comprising: a) crosslinking the genomic DNA of the cell to the histones of the cell, thereby producing crosslinked chromatin; b) generating fragments of the crosslinked chromatin; c) acetylating all unmodified lysine residues in the histones by contacting the fragmented, crosslinked chromatin with acetic anhydride or an equivalent thereof, d) conducting parallel chromatin immunoprecipitations on the acetylated chromatin produced in step c). with (1) an H3 C-terminal tail control antibody and (2) one or more antibodies directed to acetylated lysine residues in the cleaved region of the H3NT; and e) identifying the polynucleotide fragment bound to an H3NT by detecting reduction in polynucleotide fragment enrichment with the one or more antibodies directed to acetylated lysine residues in the cleaved region relative to polynucleotide fragment enrichment with the H3 C-terminal tail control antibody. 
     In other aspects, the method further comprises identifying a subject appropriate for therapeutic treatment with MMP-9. 
     In other aspects, the method further comprises identifying genetic loci at which a matrix metalloproteinase or other histone cleavage enzyme cleaves an H3 N terminal tail. 
     Also provided is a kit for identifying a polynucleotide fragment bound to an H3 histone comprising a cleaved N-terminal tail (H3NT) in a cell, the kit comprising: a) acetic anhydride or an equivalent thereof; b) an H3 C-terminal tail control antibody; c) a full length H3 N-tail detection antibody directed to an acetylated lysine residue; and d) instructions for use. In some embodiments, the full length H3 N-tail detection antibody is a H3K14ac antibody. In other embodiments, the antibody is an H3K4ac antibody or an H3K9ac antibody. In some embodiments, a mixture of one or more of H3K14ac antibody, H3K4ac antibody, and H3K9ac antibody are used to detect the full length acetylated H3 N-terminal tail. In some aspects, the kit may further comprise buffers, negative control antibodies, enzymes, methylene blue, and/or other reagents necessary to perform chromatin immunoprecipitation. The standard reagents necessary to perform chromatin immunoprecipitation, qPCR, and DNA seq are well known in the art. 
     Also provided is a method to modulate H3NT proteolysis during osteoclastogenesis in a cell, comprising, or alternatively consisting essentially of, or yet further consisting of, modulating the activity of MMP-9 in the cell. In one aspect, H3NT proteolysis is increased by increasing MMP-9 activity in the cell. In another aspect, the H3NT proteolysis is decreased by depletion or inhibit of MMP-9 activity in the cell. Diseases or pathological conditions associated with over- or under-osteoclastogenesis also can be treated by administering to a subject in need thereof an effective amount of the MMP-9 promoting or inhibiting agent. Agents that activate or promote MMP-9 activity include recombinant or isolated MMP-9 protein and epidermal growth factor has been shown to increase the expression and activity of MMP-9 (see WO 2002/045740). 
     Also provided herein is a method to modulate H3NT proteolysis in a cell, comprising modulating the activity of MMP-9 in the cell. In some aspects, H3NT proteolysis is increased by increasing MMP-9 activity in the nucleus of the cell. In further aspects, MMP-9 activity is increased by increasing nuclear localization of MMP-9, increasing acetylation of H3K18 residues, and/or overexpression of MMP-9. In other aspects, H3NT proteolysis is decreased by depletion or inhibition of MMP-9 activity in the cell. In further aspects, MMP-9 activity is decreased by knockdown of MMP-9 mRNA, treatment with CBP/p300 inhibitor, and/or treatment with a metalloprotease inhibitor. Knockdown of MMP-9 mRNA can comprise treatment with MMP-9 shRNA and/or treatment with a mesenchymal stem cell expressing MMP-9 shRNA. 
     In the above methods, a cell is a prokaryotic or a eukaryotic cell, and when an eukaryotic cell can be a mammalian cell, e.g., a mouse, canine, feline, ovine, simian or a human cell. In the above methods, a cell may be an osteoclast, an osteoclast precursor cell, or a stem or progenitor cell that can be differentiated into an osteoclast. 
     Also provided herein is a method to attenuate osteoclast formation and/or differentiation in a subject, comprising, or alternatively consisting essentially of, or yet further consisting of, administering to the subject an effective amount of a MMP-9 agent, inhibitor, or activator to the subject. In several aspects, the subject is a mammal, e.g., a mouse, a canine, a feline, an ovine, a simian or a human patient. These methods can be used therapeutically or in veterinary applications, or alternatively, as an animal model to assay for new therapies or treatments. The agents can be used alone or in combination with other known therapies. 
     Also provided herein is a method of treating a subject with low bone mineral density, comprising administering to the subject an agent that decreases or inhibiting the activity of MMP-9 in the subject. In several aspects, the subject is a mammal, e.g., a mouse, a canine, a feline, an ovine, a simian or a human patient. These methods can be used therapeutically or in veterinary applications, or alternatively, as an animal model to assay for new therapies or treatments. The agents can be used alone or in combination with other known therapies. In some aspects, the subject has a bone related disease or condition selected from osteoporosis, bone cancer, cancer that has metastasized to the bone, cancer-induced osteolysis, sepsis, rheumatoid arthritis, and periodontitis. 
     Also provided herein is a method of treating a subject with high bone mineral density, comprising administering to the subject an agent that increases the activity of MMP-9 in the subject. In several aspects, the subject is a mammal, e.g., a mouse, a canine, a feline, an ovine, a simian or a human patient. These methods can be used therapeutically or in veterinary applications, or alternatively, as an animal model to assay for new therapies or treatments. The agents can be used alone or in combination with other known therapies. In some aspects, the subject has a bone related disease or condition selected from osteopetrosis, pycondysostosis, osteopoikilosis, meloreostosis, sclerosteosis, van Buchem&#39;s disease, LRP5 high bone mass, LRP4 high bone mass, craniometaphyseal dysplasia, Camurati-Engelmann disease, Ghosal syndrome, bone cancer, cancer metastasized to the bone, fluorosis, renal osteodystrophy, acromegaly, hepatitis C-associated osteosclerosis, myelofibrosis, mastocytosis, osseous tuberous sclerosis, Paget&#39;s disease, and SAPHO syndrome. 
     BRIEF DESCRIPTION OF THE DRAWINGS 
       FIGS. 1A to 1G  shows identification of MMP-9 as a novel H3NT protease. 
       FIGS. 1A-1G .  FIG. 1A  shows primary mouse OCP cells were cultured with RANKL to induce osteoclastogenesis. OCP-induced cells were fixed, stained for TRAP, and photographed under a light microscope (10×) at the indicated days. TRAP-positive cells containing 3 or more nuclei represent osteoclasts.  FIG. 1B  shows western blot analysis of chromatin extracted from OCP-induced cells using antibodies recognizing the C-terminal histone regions as indicated.  FIG. 1C  shows nuclear extracts from 3-day OCP-induced cells were fractionated on a P11 column by increased salt concentration, as indicated, and the in vitro H3NT cleavage assay was performed to identify H3NT active fractions by Western blot analysis using the H3CT antibody. The indicated H3NT active fractions were fractionated on a Q-Sepharose column followed by a 10-40% glycerol gradient.  FIG. 1D  shows H3NT cleavage assays of purified fractions #3-5 treated with different protease family inhibitors as indicated.  FIG. 1E  shows H3NT cleavage assays of purified fractions #3-5 treated with metalloproteinase inhibitors EDTA, CTT or a selective MMP-9 inhibitor.  FIG. 1F  shows Proteomic analysis of known proteases identified in purified fractions #3-5.  FIG. 1G  shows H3NT cleavage assays using recombinant MMP-9, USP14, USP39 and DIM1. 
       FIGS. 2A to 2D  show MMP-9-dependent H3NT proteolysis during osteoclastogenesis. 
       FIGS. 2A-2D .  FIG. 2A  shows western blot analysis for MMP-9 using whole cell (top) or nuclear (bottom) lysates isolated from OCP-induced cells at the indicated days. Proform and active MMP-9 are indicated.  FIG. 2B  shows gelatin zymography of nuclear lysates isolated from OCP-induced cells expressing a control (top) or MMP-9-specific (bottom) shRNA at the indicated days.  FIG. 2C  shows Western blot analysis of nuclear lysates from 3-day OCP-induced cells expressing a control (left) or MMP-9-specific (right) shRNA using the indicated antibodies.  FIG. 2D  shows OCP cells transduced with a control or MMP-9-specific shRNA (top) or treated with DMSO control or a selective MMP-9 inhibitor (bottom). H3NT cleavage was assessed at the indicated days post-induction. 
       FIGS. 3A to 3D  show H3K18 is the principal site of MMP-9 proteolysis. 
       FIGS. 3A-3D .  FIG. 3A  shows peptide sequences (SEQ ID NOS 25-37, respectively, in order of appearance) identified by LC-MS/MS of the gel-excised rH3 product (H3Δ19) generated by rMMP-9.  FIG. 3B  shows putative MMP-9 cleavage site identified in the H3NT (aa6-21) in silico. Amino acids that are more (light) or less (dark) conserved in the canonical MMP-9 consensus sequence are indicated.  FIG. 3B  discloses SEQ ID NO: 38.  FIG. 3C  shows H3NT cleavage assays using rMMP-9 and rH3 wild type (WT) or mutant substrates as indicated.  FIG. 3D  shows OCP cells were transduced with WT or mutant H3-FLAG. Chromatin was isolated on the indicated days post-induction for Western blot analysis using a FLAG antibody to specifically detect proteolysis of H3-FLAG. 
       FIGS. 4A to 4E  show acetylation status of H3K18 regulates MMP-9 activity. 
       FIGS. 4A-4E .  FIG. 4A  shows the indicated H3 peptides (aa10-35) were incubated with increasing concentrations of rMMP-9 (x-axis) and proteolysis was measured fluorometrically by reaction of free amino groups with fluorescamine (y-axis). The V max  and K m  values were obtained by non-linear regression fit.  FIG. 4B  shows H3NT cleavage assays using rMMP-9 and the indicated rH3 acetyl-lysine analogues substrates either alone (top) or as reconstituted nucleosome arrays (bottom).  FIG. 4C  shows H3NT cleavage assays using rMMP-9 and recombinant (top) or native (bottom) nucleosome array substrates.  FIG. 4D  shows Western blot analysis of nuclear lysates from 3-day OCP-induced cells expressing a control or CBP/p300-specific shRNA using the indicated antibodies.  FIG. 4E  shows OCP cells transduced with a control or CBP/p300-specific shRNA (top) or treated with DMSO control or a selective CBP/p300 inhibitor (bottom). H3NT cleavage was assessed at the indicated days post-induction. 
       FIGS. 5A to 5D  show MMP-9 is required for osteoclastogenic gene activation and proficient osteoclast differentiation. 
       FIGS. 5A-5D .  FIG. 5A  shows scatter plot of RNA-Seq normalized RPKM levels of annotated genes from 3-day OCP-induced cells expressing a control (x-axis) or MMP-9-specific (y-axis) shRNA. Genes with significantly increased (light gray) or decreased (dark gray) expression in MMP-9 depleted cells relative to control cells were defined based on FDR adjusted p&lt;0.05 and log 2 ratio±0.7.  FIG. 5B  shows GSEA of the 758 genes displaying impaired activation in MMP-9 depleted cells (x-axis) were ranked by increasing expression differences (light curve) relative to control cells (y-axis).  FIG. 5C  shows expression differences of the indicated 26 osteoclastogenic genes identified in  FIG. 6B  between control (left) and MMP-9 depleted (right) 3-day OCP-induced cells displayed as a heat map in the pseudo color scale indicated.  FIG. 5D  shows Visualization (10×) of TRAP stained 5-day OCP-induced cells expressing a control, MMP-9-specific or CBP/p300-specific shRNA (top) or treated with DMSO control, a selective MMP-9 inhibitor or a selective CBP/p300 inhibitor (bottom). 
       FIGS. 6A to 6C  show selective targeting of MMP-9-dependent H3NT proteolysis near TSSs during osteoclastogenesis. 
       FIGS. 6A-6C .  FIG. 6A  shows schematic of ChIPac-Seq. Cells were fixed with methylene blue and chromatin extracted. Crosslinked chromatin was sonicated to generate nucleosomes containing full length (left) and NT-cleaved (right) H3. Acetic anhydride was used to artificially acetylate all unmodified lysines (indicated as lollipops on the H3). ChIPac was performed for H3CT control, to enrich all nucleosomes, or H3K14ac, to enrich only H3NT-containing nucleosomes.  FIG. 6B  shows Comparative ChIPac-Seq analyses of control (left) and MMP-9 depleted (right) 3-day OCP-induced cells for enrichment (dark) or depletion (light) of H3CT control (left) or H3K14ac (right) near TSS (+/−4 kb) of all known protein coding genes. K means clustering identified specific H3NT-cleaved TSSs at either promoters (P), coding regions (CR) or both (P+CR).  FIG. 6C  shows average tag density profiles (y-axis) of each H3NT-cleaved group near TSS (x-axis) for H3CT and H3K14ac in control and MMP-9 depleted 3-day OCP-induced cells as indicated. 
       FIGS. 7A to 7D  show CBP/p300-mediated acetylation of H3K18 regulates the sites and extent of MMP-9 H3NT proteolysis. 
       FIGS. 7A-7D .  FIG. 7A  shows distribution of all H3NT-cleaved genes displaying no change (grey) or significantly changed expression (dark) between MMP-9 depleted and control 3-day OCP-induced cells (left). Distribution of H3NT-cleaved genes dependent on MMP-9 for activation (light) or repression (black) in 3-day OCP-induced cells (right).  FIG. 7B  shows fold expression changes (y-axis) of Nfatc1, Lif and Xpr1 normalized to β-actin in 3-day OCP-induced cells expressing a control (dark, first two bars in graph), MMP-9-specific (medium gray, middle two bars in each graph) or CBP/p300-specific (light gray, right two bars in each graph) shRNA relative to non-induced OCP cells.  FIG. 7C  shows ChIPac was performed with H3K14ac-specific (H3NT, left) and H3CT control (right) antibodies in 3-day control (−) or RANKL-induced (+) OCP cells expressing a control, MMP-9-specific or CBP/p300-specific shRNA (x-axis). qPCR was performed at the promoters (P, left) and coding regions (CR, right) of Nfatc1 (P-cleaved), Lif (CR-cleaved) and Xpr1 (P+C-cleaved). Enrichments were plotted relative to non-induced control shRNA OCP cells (first column) (y-axis). Star indicates H3NT cleavage.  FIG. 7D  shows ChIP-qPCR analysis of H3K18ac as described above. Star indicates significantly increased H3K18ac enrichment. 
       FIGS. 8A-8B .  FIG. 8A  shows in vitro H3NT cleavage assays performed with the purified glycerol gradient fractions #3-5 ( FIG. 1C ) or recombinant MMP-9 (rMMP-9) as indicated. Substrates used in the assays were reconstituted recombinant histone octamer (left), reconstituted octamer containing purified native histones from HeLa cells (center) or reconstituted native nucleosome arrays (right). Western blot analysis was performed using antibodies that detect the C-terminal tail of each indicated core histone (left).  FIG. 8B  shows in vitro H3NT cleavage assays as described above using recombinant H3.1, H3.2 or H3.3 substrates in the absence (left) or presence (right) of rMMP-9. 
       FIGS. 9A-9B .  FIG. 9A  shows western blot analysis of cytosolic (left) and nuclear (right) lysates isolated in parallel from OCP-induced cells at the indicated days for MMP-9, GAPDH (cytosol control) and histone H4 (nucleus control). The volumes and total amount of protein (20 μg) loaded per lane were identical in all samples.  FIG. 9B  shows confocal microscopy of OCP-induced cells co-stained for MMP-9 and DAPI at the indicated days (left). OCP cells were grown on glass cover slips, fixed with 4% paraformaldehyde for 15 min and permeabilized with 0.25% Triton X-100 in phosphate-buffered saline (PBS) for 5 min. Cells were blocked with PBS+2% goat serum (GS) in PBS for 60 minutes prior to incubation with an MMP-9 antibody (Santa Cruz). Cells were washed with PBS+GS, incubated with a FITC conjugated secondary antibody (Jackson Laboratory) and mounted with VectaShield with DAPI (Vector Laboratories). 
       FIGS. 10A-10B .  FIG. 10A  shows the human histone H3 amino acid sequence (SEO ID NO: 39) was analyzed by PROSPER (see prosper.erc.monash.edu.au) to identify predicted sites of H3 proteolysis (SEQ ID NOS 40-47, respectively, in order of appearance). The only potential cleavage site identified in the H3NT was K18, which was predicted to be cleaved by MMP-9 (inset).  FIG. 10B  shows the log-odds probabilities of amino acids (y-axis) in the P3-P2′ position (x-axis) of substrates known to be proteolyzed by MMP-9 was generated from PMAP (www.proteolysis. org). 
       FIGS. 11A-11C .  FIG. 11A  shows recombinant H3 wild type (WT) and mono-, di- and trimethyl-lysine analogues (top) for H3K4, H3K9, H3K27 and H3K36 (left) were used as substrates in in vitro H3NT cleavage assays with rMMP-9.  FIG. 11B  shows OCP cells were transduced with H3K18 acetyltransferase-specific shRNAs as indicated. Knock-down specificity and efficiency of each acetyltransferase shRNA were determined by RT-qPCR to quantitate expression changes relative to control shRNA (y-axis) for each gene (x-axis).  FIG. 11C  shows chromatin was extracted from OCP cells expressing a control or acetyltransferase-specific shRNA (left) at the indicated days post-induction (top) for Western analysis with the H3CT antibody to detect H3NT proteolysis. 
       FIGS. 12A-12D .  FIG. 12A  shows genomic distribution of uniquely mapped RNA-Seq reads from control (dark) and MMP-9 (light) shRNA expressing 3-day OCP-induced cells was similar with most reads mapping to coding regions of the mouse genome.  FIG. 12B  shows gene body coverage plot between control (dark) and MMP-9 (light) shRNA expressing 3-day OCP-induced cells demonstrating a similar uniform coverage across gene bodies with no significant 5′ or 3′ bias.  FIG. 12C  shows gene ontology analysis of the 758 genes displaying impaired activation in MMP-9 depleted 3-day OCP-induced cells relative to control OCP cells.  FIG. 12D  shows OCP cells transduced with a control (grey), MMP-9-specific (dark) or CBP/p300-specific (light) shRNA (left) or cultured with DMSO control (grey), a MMP-9-specific inhibitor (dark) or a CBP/p300 inhibitor (light) (right) were treated with RANKL for 5 days (x-axis). Cells were fixed, stained with a TRAP kit (Sigma) and visualized by light microscopy (10×). The number of osteoclasts (y-axis) was determined by counting TRAP-positive cells containing 3 or more nuclei in each sample. 
       FIGS. 13A-13E .  FIG. 13A  shows OCP cells were crosslinked with different concentrations of methylene blue (0, 5, 10 and 20 μM) for the indicated times (x-axis). Chromatin was extracted and DNA-protein crosslinking efficiency was measured by SDS-chloroform-isoamyl alcohol (SDS-CIA) (y-axis).  FIG. 13B  shows unmodified and K14ac H3 peptides (aa10-35) and methylene blue crosslinked chromatin (10 or 20 μM) treated with acetic anhydride were spotted on nitrocellulose for Western analysis with the indicated antibodies.  FIG. 13C  shows genomic snapshots of the Nfatc1 (left), Xpr1 (center) and Lif (right) genes showing the normalized tracks of H3CT control and H3K14ac ChIPac-Seq data (top) and RNA-Seq data (bottom) from control and MMP-9 depleted 3-day OCP-induced cells as indicated. Numbers in parentheses indicate maximum sequencing depth for each sample. Grey boxes indicate the region near TSS (dashed line) displayed in  FIG. 6D .  FIG. 13D  shows heat map showing one dimensional clustering in a single color channel of all genes displaying H3NT cleavage ( FIG. 6B  and Table 2). Euclidean distance and average linkage were used for clustering. Normalized read count values corresponding to each gene are plotted and colored proportional to the level of read counts as indicated in the color bar.  FIG. 13E  shows to investigate potential functional similarities and differences between the identified P, CR and P+CR H3NT-cleaved genes (Table 2), the Wikipathway database was queried and a ranked p-value was computed for each pathway from the Fisher exact test based on the bionomical distribution and independence for probability of any gene belonging to any enriched set. The RANKL and several osteoclastogenic pathways were significantly enriched (p&lt;0.0001) when all H3NT-cleaved genes were analyzed (dark), consistent with RNA-Seq results ( FIG. 12C ). These pathways were also significantly enriched independently for P and CR H3NT-cleaved genes but not for P+CR (brown, p&gt;0.9). 
       FIG. 14 .  FIG. 14  shows OCP cells were treated with DMSO control (1), a selective MMP-9 inhibitor (2) or a selective CBP/p300 inhibitor (3) and cultured with (+) or without (−) RANKL for 3 days (x-axis). RT-qPCR was used to quantitatively measure fold expression changes (y-axis) of the osteoclastogenic genes Nfatc1, Lif and Xpr1 relative to non-induced control after normalization to β-actin expression. 
    
    
     DETAILED DESCRIPTION 
     Definitions 
     Before the compositions and methods are described, it is to be understood that the invention is not limited to the particular methodologies, protocols, cell lines, assays, and reagents described, as these may vary. It is also to be understood that the terminology used herein is intended to describe particular embodiments of the present invention, and is in no way intended to limit the scope of the present invention as set forth in the appended claims. 
     The practice of the present invention will employ, unless otherwise indicated, conventional techniques of tissue culture, immunology, molecular biology, microbiology, cell biology and recombinant DNA, which are within the skill of the art. See, e.g., Sambrook and Russell eds. (2001) Molecular Cloning: A Laboratory Manual, 3 rd  edition; the series Ausubel et al. eds. (2007) Current Protocols in Molecular Biology; the series Methods in Enzymology (Academic Press, Inc., N.Y.); MacPherson et al. (1991) PCR 1: A Practical Approach (IRL Press at Oxford University Press); MacPherson et al. (1995) PCR 2: A Practical Approach; Harlow and Lane eds. (1999) Antibodies, A Laboratory Manual; Freshney (2005) Culture of Animal Cells: A Manual of Basic Technique, 5 th  edition; Gait ed. (1984) Oligonucleotide Synthesis; U.S. Pat. No. 4,683,195; Hames and Higgins eds. (1984) Nucleic Acid Hybridization; Anderson (1999) Nucleic Acid Hybridization; Hames and Higgins eds. (1984) Transcription and Translation; Immobilized Cells and Enzymes (IRL Press (1986)); Perbal (1984) A Practical Guide to Molecular Cloning; Miller and Calos eds. (1987) Gene Transfer Vectors for Mammalian Cells (Cold Spring Harbor Laboratory); Makrides ed. (2003) Gene Transfer and Expression in Mammalian Cells; Mayer and Walker eds. (1987) Immunochemical Methods in Cell and Molecular Biology (Academic Press, London); Herzenberg et al. eds (1996) Weir&#39;s Handbook of Experimental Immunology; Manipulating the Mouse Embryo: A Laboratory Manual, 3 rd  edition (Cold Spring Harbor Laboratory Press (2002)); Current Protocols In Molecular Biology (F. M. Ausubel, et al. eds., (1987)); the series Methods in Enzymology (Academic Press, Inc.): PCR 2: A Practical Approach (M. J. MacPherson, B. D. Hames and G. R. Taylor eds. (1995)); Harlow and Lane, eds. (1988) Antibodies, A Laboratory Manual; Harlow and Lane, eds. (1999) Using Antibodies, A Laboratory Manual; Animal Cell Culture (R. I. Freshney, ed. (1987)); Zigova, Sanberg and Sanchez-Ramos, eds. (2002) Neural Stem Cells. 
     All numerical designations, e.g., pH, temperature, time, concentration, and molecular weight, including ranges, are approximations which are varied (+) or (−) by increments of 0.1 or 1 where appropriate. It is to be understood, although not always explicitly stated that all numerical designations are preceded by the term “about”. The term “about” also includes the exact value “X” in addition to minor increments of “X” such as “X+0.1 or 1” or “X−0.1 or 1,” where appropriate. It also is to be understood, although not always explicitly stated, that the reagents described herein are merely exemplary and that equivalents of such are known in the art. 
     As will be understood by one skilled in the art, for any and all purposes, particularly in terms of providing a written description, all ranges disclosed herein also encompass any and all possible subranges and combinations of subranges thereof. Any listed range can be easily recognized as sufficiently describing and enabling the same range being broken down into at least equal halves, thirds, quarters, fifths, tenths, etc. As a non-limiting example, each range discussed herein can be readily broken down into a lower third, middle third and upper third, etc. As will also be understood by one skilled in the art all language such as “up to,” “at least,” “greater than,” “less than,” and the like include the number recited and refer to ranges which can be subsequently broken down into subranges as discussed above. 
     As used in the specification and claims, the singular form “a”, “an” and “the” include plural references unless the context clearly dictates otherwise. For example, the term “a cell” includes a plurality of cells, including mixtures thereof. 
     As used herein, the term “comprising” is intended to mean that the compositions and methods include the recited elements, but not excluding others. “Consisting essentially of” when used to define compositions and methods, shall mean excluding other elements of any essential significance to the combination for the stated purpose. Thus, a composition consisting essentially of the elements as defined herein would not exclude trace contaminants from the isolation and purification method and pharmaceutically acceptable carriers, such as phosphate buffered saline, preservatives and the like. “Consisting of” shall mean excluding more than trace elements of other ingredients and substantial method steps for administering the compositions of this invention or process steps to produce a composition or achieve an intended result. Embodiments defined by each of these transition terms are within the scope of this disclosure. 
     The term “isolated” as used herein with respect to proteins, polypeptides, cells, nucleic acids, such as DNA or RNA, refers to molecules separated from other proteins, polypeptides, cells, nucleic acids, such as DNA or RNA, respectively, that are present in the natural source of the macromolecule. The term “isolated” as used herein also refers to a nucleic acid or peptide that is substantially free of cellular material, viral material, or culture medium when produced by recombinant DNA techniques, or chemical precursors or other chemicals when chemically synthesized. 
     As used herein, the term “recombinant” as it pertains to polypeptides or polynucleotides intends a form of the polypeptide or polynucleotide that does not exist naturally, a non-limiting example of which can be created by combining polynucleotides or polypeptides that would not normally occur together. A recombinant polynucleotide is a polynucleotide created or replicated using techniques (chemical or using host cells) other than by a cell in its native environment. 
     “Cells,” “host cells” or “recombinant host cells” are terms used interchangeably herein. It is understood that such terms refer not only to the particular subject cell but also to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein. 
     The terms “polynucleotide” and “oligonucleotide” are used interchangeably and refer to a polymeric form of nucleotides of any length, either deoxyribonucleotides or ribonucleotides or analogs thereof. Polynucleotides can have any three-dimensional structure and may perform any function, known or unknown. The following are non-limiting examples of polynucleotides: a gene or gene fragment (for example, a probe, primer, EST or SAGE tag), exons, introns, messenger RNA (mRNA), transfer RNA, ribosomal RNA, ribozymes, cDNA, dsRNA, siRNA, miRNA, recombinant polynucleotides, branched polynucleotides, plasmids, vectors, isolated DNA of any sequence, isolated RNA of any sequence, nucleic acid probes and primers. A polynucleotide can comprise modified nucleotides, such as methylated nucleotides and nucleotide analogs. If present, modifications to the nucleotide structure can be imparted before or after assembly of the polynucleotide. The sequence of nucleotides can be interrupted by non-nucleotide components. A polynucleotide can be further modified after polymerization, such as by conjugation with a labeling component. The term also refers to both double- and single-stranded molecules. Unless otherwise specified or required, any embodiment of this invention that is a polynucleotide encompasses both the double-stranded form and each of two complementary single-stranded forms known or predicted to make up the double-stranded form. In some aspects of the disclosed methods, a “polynucleotide fragment” refers to a piece of genomic DNA that has been fragmented by a method such as sonication or enzymatic fragmentation. Such fragments may vary in size based on the conditions of the fragmentation. A polynucleotide fragment may be crosslinked to histones and other proteins associated with chromatin. 
     A polynucleotide is composed of a specific sequence of four nucleotide bases: adenine (A); cytosine (C); guanine (G); thymine (T); and uracil (U) for thymine when the polynucleotide is RNA. Thus, the term “polynucleotide sequence” is the alphabetical representation of a polynucleotide molecule. This alphabetical representation can be input into databases in a computer having a central processing unit and used for bioinformatics applications such as functional genomics and homology searching. 
     “Amplify” “amplifying” or “amplification” of a polynucleotide sequence includes methods such as traditional cloning methodologies, PCR, ligation amplification (or ligase chain reaction, LCR) or other amplification methods. These methods are known and practiced in the art. See, e.g., U.S. Pat. Nos. 4,683,195 and 4,683,202 and Innis et al. (1990) Mol. Cell Biol. 10(11):5977-5982 (for PCR); and Wu et al. (1989) Genomics 4:560-569 (for LCR). In general, the PCR procedure describes a method of gene amplification which is comprised of (i) sequence-specific hybridization of primers to specific genes within a DNA sample (or library), (ii) subsequent amplification involving multiple rounds of annealing, elongation, and denaturation using a DNA polymerase, and (iii) screening the PCR products for a band of the correct size. The primers used are oligonucleotides of sufficient length and appropriate sequence to provide initiation of polymerization, i.e. each primer is specifically designed to be complementary to each strand of the genomic locus to be amplified. 
     Reagents and hardware for conducting PCR are commercially available. Primers useful to amplify sequences from a particular region are preferably complementary to, and hybridize specifically to sequences in the target region or in its flanking regions. Nucleic acid sequences generated by amplification may be sequenced directly. Alternatively the amplified sequence(s) may be cloned prior to sequence analysis. A method for the direct cloning and sequence analysis of enzymatically amplified genomic segments is known in the art. 
     The term “genotype” refers to the specific allelic composition of an entire cell, a certain gene or a specific polynucleotide region of a genome, whereas the term “phenotype’ refers to the detectable outward manifestations of a specific genotype. 
     As used herein, the term “gene” or “recombinant gene” refers to a nucleic acid molecule comprising an open reading frame and including at least one exon and (optionally) an intron sequence. A gene may also refer to a polymorphic or a mutant form or allele of a gene. 
     “Homology” or “identity” or “similarity” refers to sequence similarity between two peptides or between two nucleic acid molecules. Homology can be determined by comparing a position in each sequence that may be aligned for purposes of comparison. When a position in the compared sequence is occupied by the same base or amino acid, then the molecules are homologous at that position. A degree of homology between sequences is a function of the number of matching or homologous positions shared by the sequences. An “unrelated” or “non-homologous” sequence shares less than 40% identity, though preferably less than 25% identity, with one of the sequences of the present invention. 
     A polynucleotide or polynucleotide region (or a polypeptide or polypeptide region) has a certain percentage (for example, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98% or 99%) of “sequence identity” to another sequence means that, when aligned, that percentage of bases (or amino acids) are the same in comparing the two sequences. This alignment and the percent homology or sequence identity can be determined using software programs known in the art, for example those described in Ausubel et al. eds. (2007) Current Protocols in Molecular Biology. Preferably, default parameters are used for alignment. One alignment program is BLAST, using default parameters. In particular, programs are BLASTN and BLASTP, using the following default parameters: Genetic code=standard; filter=none; strand=both; cutoff=60; expect=10; Matrix=BLOSUM62; Descriptions=50 sequences; sort by=HIGH SCORE; Databases=non-redundant, GenBank+EMBL+DDBJ+PDB+GenBank CDS translations+SwissProtein+SPupdate+PIR. Details of these programs can be found at the following Internet address: http://www.ncbi.nlm.nih.gov, last accessed on May 21, 2008. Biologically equivalent polynucleotides are those having the above-noted specified percent homology and encoding a polypeptide having the same or similar biological activity. 
     In one aspect, the term “equivalent” as it refers to polypeptides, proteins, or polynucleotides refers to polypeptides, proteins, or polynucleotides, respectively having a sequence having a certain degree of homology or identity with the reference sequence of the polypeptides, proteins, or polynucleotides (or complement thereof when referring to polynucleotides). A homolog of a double stranded nucleic acid is intended to include nucleic acids having a nucleotide sequence that has a certain degree of homology with or with the complement thereof. In one aspect, homologs of nucleic acids are capable of hybridizing to the nucleic acid or complement thereof. In one aspect, an equivalent has at least 70%, or at least 75% or at least 80%, or at least 85%, or at least 90%, or at least 95%, or at least 97%, or at least 98%, sequence identity to the reference polynucleotide or polypeptide. 
     Hybridization reactions can be performed under conditions of different “stringency”. In general, a low stringency hybridization reaction is carried out at about 40° C. in about 10×SSC or a solution of equivalent ionic strength/temperature. A moderate stringency hybridization is typically performed at about 50° C. in about 6×SSC, and a high stringency hybridization reaction is generally performed at about 60° C. in about 1×SSC. Hybridization reactions can also be performed under “physiological conditions” which is well known to one of skill in the art. A non-limiting example of a physiological condition is the temperature, ionic strength, pH and concentration of Mg 2+  normally found in a cell. 
     As used herein, the term “oligonucleotide” refers to polynucleotides such as deoxyribonucleic acid (DNA), and, where appropriate, ribonucleic acid (RNA). The term should also be understood to include, as equivalents, derivatives, variants and analogs of either RNA or DNA made from nucleotide analogs, and, as applicable to the embodiment being described, single (sense or antisense) and double-stranded polynucleotides. Deoxyribonucleotides include deoxyadenosine, deoxycytidine, deoxyguanosine, and deoxythymidine. For purposes of clarity, when referring herein to a nucleotide of a nucleic acid, which can be DNA or an RNA, the terms “adenosine”, “cytidine”, “guanosine”, and “thymidine” are used. It is understood that if the nucleic acid is RNA, a nucleotide having a uracil base is uridine. 
     A “gene delivery vehicle” is defined as any molecule that can carry inserted polynucleotides into a host cell. Examples of gene delivery vehicles are liposomes, biocompatible polymers, including natural polymers and synthetic polymers; lipoproteins; polypeptides; polysaccharides; lipopolysaccharides; artificial viral envelopes; metal particles; and bacteria, or viruses, such as baculovirus, adenovirus and retrovirus, bacteriophage, cosmid, plasmid, fungal vectors and other recombination vehicles typically used in the art which have been described for expression in a variety of eukaryotic and prokaryotic hosts, and may be used for gene therapy as well as for simple protein expression. 
     “Gene delivery,” “gene transfer,” and the like as used herein, are terms referring to the introduction of an exogenous polynucleotide (sometimes referred to as a “transgene”) into a host cell, irrespective of the method used for the introduction. Such methods include a variety of well-known techniques such as vector-mediated gene transfer (by, e.g., viral infection, sometimes called transduction), transfection, transformation or various other protein-based or lipid-based gene delivery complexes) as well as techniques facilitating the delivery of “naked” polynucleotides (such as electroporation, “gene gun” delivery and various other techniques used for the introduction of polynucleotides). Unless otherwise specified, the term transfected, transduced or transformed may be used interchangeably herein to indicate the presence of exogenous polynucleotides or the expressed polypeptide therefrom in a cell. The introduced polynucleotide may be stably or transiently maintained in the host cell. Stable maintenance typically requires that the introduced polynucleotide either contains an origin of replication compatible with the host cell or integrates into a replicon of the host cell such as an extrachromosomal replicon (e.g., a plasmid) or a nuclear or mitochondrial chromosome. A number of vectors are known to be capable of mediating transfer of genes to mammalian cells, as is known in the art and described herein. 
     The term “express” refers to the production of a gene product. 
     As used herein, “expression” refers to the process by which polynucleotides are transcribed into RNA such as mRNA and/or the process by which a transcribed mRNA is subsequently translated into peptides, polypeptides, or proteins. If the polynucleotide is derived from genomic DNA, expression may include splicing of the mRNA in an eukaryotic cell. 
     A “gene product” or alternatively a “gene expression product” refers to the amino acid (e.g., peptide or polypeptide) generated when a gene is transcribed and translated. 
     “Under transcriptional control” is a term well understood in the art and indicates that transcription of a polynucleotide sequence, usually a DNA sequence, depends on its being operatively linked to an element which contributes to the initiation of, or promotes, transcription. “Operatively linked” intends the polynucleotides are arranged in a manner that allows them to function in a cell. 
     The term “encode” as it is applied to polynucleotides refers to a polynucleotide which is said to “encode” a polypeptide if, in its native state or when manipulated by methods well known to those skilled in the art, it can be transcribed and/or translated to produce the mRNA for the polypeptide and/or a fragment thereof. The antisense strand is the complement of such a nucleic acid, and the encoding sequence can be deduced therefrom. 
     A cell that “stably expresses” an exogenous polypeptide is one that continues to express a polypeptide encoded by an exogenous gene introduced into the cell either after replication if the cell is dividing or for longer than a day, up to about a week, up to about two weeks, up to three weeks, up to four weeks, for several weeks, up to a month, up to two months, up to three months, for several months, up to a year or more. 
     As used herein, a “vector” is a vehicle for transferring genetic material into a cell. Examples of such include, but are not limited to plasmids and viral vectors. A viral vector is a virus that has been modified to transduct genetic material into a cell. A plasmid vector is made by splicing a DNA construct into a plasmid. As is apparent to those of skill in the art, the appropriate regulatory elements are included in the vectors to guide replication and/or expression of the genetic material in the selected host cell. 
     A “viral vector” is defined as a recombinantly produced virus or viral particle that comprises a polynucleotide to be delivered into a host cell, either in vivo, ex vivo or in vitro. Examples of viral vectors include retroviral vectors, lentiviral vectors, adenovirus vectors, adeno-associated virus vectors, alphavirus vectors and the like. Alphavirus vectors, such as Semliki Forest virus-based vectors and Sindbis virus-based vectors, have also been developed for use in gene therapy and immunotherapy. See, Schlesinger and Dubensky (1999) Curr. Opin. Biotechnol. 5:434-439 and Ying et al. (1999) Nat. Med. 5(7):823-827. 
     In aspects where gene transfer is mediated by a retroviral vector, a vector construct refers to the polynucleotide comprising the retroviral genome or part thereof, and a therapeutic gene. As used herein, “retroviral mediated gene transfer” or “retroviral transduction” carries the same meaning and refers to the process by which a gene or nucleic acid sequences are stably transferred into the host cell by virtue of the virus entering the cell and integrating its genome into the host cell genome. The virus can enter the host cell via its normal mechanism of infection or be modified such that it binds to a different host cell surface receptor or ligand to enter the cell. Retroviruses carry their genetic information in the form of RNA; however, once the virus infects a cell, the RNA is reverse-transcribed into the DNA form which integrates into the genomic DNA of the infected cell. The integrated DNA form is called a provirus. As used herein, retroviral vector refers to a viral particle capable of introducing exogenous nucleic acid into a cell through a viral or viral-like entry mechanism. A “lentiviral vector” is a type of retroviral vector well-known in the art that has certain advantages in transducing nondividing cells as compared to other retroviral vectors. See, Trono D. (2002) Lentiviral Vectors, New York: Spring-Verlag Berlin Heidelberg. 
     In aspects where gene transfer is mediated by a DNA viral vector, such as an adenovirus (Ad) or adeno-associated virus (AAV), a vector construct refers to the polynucleotide comprising the viral genome or part thereof, and a transgene. Adenoviruses (Ads) are a relatively well characterized, homogenous group of viruses, including over 50 serotypes. See, e.g., International PCT Application No. WO 95/27071. Ads do not require integration into the host cell genome. Recombinant Ad derived vectors, particularly those that reduce the potential for recombination and generation of wild-type virus, have also been constructed. See, International PCT Application Nos. WO 95/00655 and WO 95/11984. Wild-type AAV has high infectivity and specificity integrating into the host cell&#39;s genome. See, Hermonat and Muzyczka (1984) Proc. Natl. Acad. Sci. USA 81:6466-6470 and Lebkowski et al. (1988) Mol. Cell. Biol. 8:3988-3996. 
     Vectors that contain both a promoter and a cloning site into which a polynucleotide can be operatively linked are well known in the art. Such vectors are capable of transcribing RNA in vitro or in vivo, and are commercially available from sources such as Stratagene (La Jolla, Calif.) and Promega Biotech (Madison, Wis.). In order to optimize expression and/or in vitro transcription, it may be necessary to remove, add or alter 5′ and/or 3′ untranslated portions of the clones to eliminate extra, potential inappropriate alternative translation initiation codons or other sequences that may interfere with or reduce expression, either at the level of transcription or translation. Alternatively, consensus ribosome binding sites can be inserted immediately 5′ of the start codon to enhance expression. 
     Gene delivery vehicles also include several non-viral vectors, including DNA/liposome complexes, and targeted viral protein-DNA complexes. Liposomes that also comprise a targeting antibody or fragment thereof can be used in the methods of this invention. To enhance delivery to a cell, the nucleic acid or proteins of this invention can be conjugated to antibodies or binding fragments thereof which bind cell surface antigens, e.g., a cell surface marker found on stem cells. 
     A “plasmid” is an extra-chromosomal DNA molecule separate from the chromosomal DNA which is capable of replicating independently of the chromosomal DNA. In many cases, it is circular and double-stranded. Plasmids provide a mechanism for horizontal gene transfer within a population of microbes and typically provide a selective advantage under a given environmental state. Plasmids may carry genes that provide resistance to naturally occurring antibiotics in a competitive environmental niche, or alternatively the proteins produced may act as toxins under similar circumstances. 
     “Plasmids” used in genetic engineering are called “plasmic vectors”. Many plasmids are commercially available for such uses. The gene to be replicated is inserted into copies of a plasmid containing genes that make cells resistant to particular antibiotics and a multiple cloning site (MCS, or polylinker), which is a short region containing several commonly used restriction sites allowing the easy insertion of DNA fragments at this location. Another major use of plasmids is to make large amounts of proteins. In this case, researchers grow bacteria containing a plasmid harboring the gene of interest. Just as the bacteria produces proteins to confer its antibiotic resistance, it can also be induced to produce large amounts of proteins from the inserted gene. This is a cheap and easy way of mass-producing a gene or the protein it then codes for. 
     “Eukaryotic cells” comprise all of the life kingdoms except monera. They can be easily distinguished through a membrane-bound nucleus. Animals, plants, fungi, and protists are eukaryotes or organisms whose cells are organized into complex structures by internal membranes and a cytoskeleton. The most characteristic membrane-bound structure is the nucleus. A eukaryotic host, including, for example, yeast, higher plant, insect and mammalian cells. Non-limiting examples include simian, bovine, ovine, porcine, murine, rats, canine, equine, feline, avian, reptilian and human. 
     “Prokaryotic cells” that usually lack a nucleus or any other membrane-bound organelles and are divided into two domains, bacteria and archaea. Additionally, instead of having chromosomal DNA, these cells&#39; genetic information is in a circular loop called a plasmid. Bacterial cells are very small, roughly the size of an animal mitochondrion (about 1-2 μm in diameter and 10 μm long). Prokaryotic cells feature three major shapes: rod shaped, spherical, and spiral. Instead of going through elaborate replication processes like eukaryotes, bacterial cells divide by binary fission. Examples include but are not limited to prokaryotic Cyanobacteria,  bacillus  bacteria,  E. coli  bacterium, and  Salmonella  bacterium. 
     The term “propagate” means to grow a cell or population of cells. The term “growing” also refers to the proliferation of cells in the presence of supporting media, nutrients, growth factors, support cells, or any chemical or biological compound necessary for obtaining the desired number of cells or cell type. 
     The term “culturing” refers to the in vitro propagation of cells or organisms on or in media of various kinds. It is understood that the descendants of a cell grown in culture may not be completely identical (i.e., morphologically, genetically, or phenotypically) to the parent cell. 
     A “probe” when used in the context of polynucleotide manipulation refers to an oligonucleotide that is provided as a reagent to detect a target potentially present in a sample of interest by hybridizing with the target. Usually, a probe will comprise a label or a means by which a label can be attached, either before or subsequent to the hybridization reaction. Suitable labels are described and exemplified herein. 
     A “primer” is a short polynucleotide, generally with a free 3′-OH group that binds to a target or “template” potentially present in a sample of interest by hybridizing with the target, and thereafter promoting polymerization of a polynucleotide complementary to the target. A “polymerase chain reaction” (“PCR”) is a reaction in which replicate copies are made of a target polynucleotide using a “pair of primers” or a “set of primers” consisting of an “upstream” and a “downstream” primer, and a catalyst of polymerization, such as a DNA polymerase, and typically a thermally-stable polymerase enzyme. Methods for PCR are well known in the art, and taught, for example in MacPherson et al. (1991) PCR: A Practical Approach, IRL Press at Oxford University Press. All processes of producing replicate copies of a polynucleotide, such as PCR or gene cloning, are collectively referred to herein as “replication.” A primer can also be used as a probe in hybridization reactions, such as Southern or Northern blot analyses. Sambrook et al., supra. The primers may optionall contain detectable labels and are exemplified and described herein. 
     As used herein, the term “detectable label” intends a directly or indirectly detectable compound or composition (other than a naturally occurring polynucleotide in its natural environment) that is conjugated directly or indirectly to the composition to be detected, e.g., polynucleotide or protein such as an antibody so as to generate an artificial, non-naturally occurring “labeled” composition. The term also includes sequences conjugated to the polynucleotide that will provide a signal upon expression of the inserted sequences, such as green fluorescent protein (GFP) and the like. The label may be detectable by itself (e.g. radioisotope labels or fluorescent labels) or, in the case of an enzymatic label, may catalyze chemical alteration of a substrate compound or composition which is detectable. The labels can be suitable for small scale detection or more suitable for high-throughput screening. As such, suitable labels include, but are not limited to radioisotopes, fluorochromes, chemiluminescent compounds, dyes, and proteins, including enzymes. The label may be simply detected or it may be quantified. A response that is simply detected generally comprises a response whose existence merely is confirmed, whereas a response that is quantified generally comprises a response having a quantifiable (e.g., numerically reportable) value such as an intensity, polarization, and/or other property. In luminescence or fluorescence assays, the detectable response may be generated directly using a luminophore or fluorophore associated with an assay component actually involved in binding, or indirectly using a luminophore or fluorophore associated with another (e.g., reporter or indicator) component. 
     Examples of luminescent labels that produce signals include, but are not limited to bioluminescence and chemiluminescence. Detectable luminescence response generally comprises a change in, or an occurrence of, a luminescence signal. Suitable methods and luminophores for luminescently labeling assay components are known in the art and described for example in Haugland, Richard P. (1996) Handbook of Fluorescent Probes and Research Chemicals (6 th  ed.). Examples of luminescent probes include, but are not limited to, aequorin and luciferases. 
     Examples of suitable fluorescent labels include, but are not limited to, fluorescein, rhodamine, tetramethylrhodamine, eosin, erythrosin, coumarin, methyl-coumarins, pyrene, Malacite green, stilbene,  Lucifer  Yellow, Cascade Blue™, and Texas Red. Other suitable optical dyes are described in the Haugland, Richard P. (1996) Handbook of Fluorescent Probes and Research Chemicals (6 th  ed.). 
     In another aspect, the fluorescent label is functionalized to facilitate covalent attachment to a cellular component present in or on the surface of the cell or tissue such as a cell surface marker. Suitable functional groups, including, but not are limited to, isothiocyanate groups, amino groups, haloacetyl groups, maleimides, succinimidyl esters, and sulfonyl halides, all of which may be used to attach the fluorescent label to a second molecule. The choice of the functional group of the fluorescent label will depend on the site of attachment to either a linker, the agent, the marker, or the second labeling agent. 
     Attachment of the fluorescent label may be either directly to the cellular component or compound or alternatively, can by via a linker. Suitable binding pairs for use in indirectly linking the fluorescent label to the intermediate include, but are not limited to, antigens/antibodies, e.g., rhodamine/anti-rhodamine, biotin/avidin and biotin/strepavidin. 
     The phrase “solid support” refers to non-aqueous surfaces such as “culture plates” “gene chips” or “microarrays.” Such gene chips or microarrays can be used for diagnostic and therapeutic purposes by a number of techniques known to one of skill in the art. In one technique, oligonucleotides are attached and arrayed on a gene chip for determining the DNA sequence by the hybridization approach, such as that outlined in U.S. Pat. Nos. 6,025,136 and 6,018,041. The polynucleotides of this invention can be modified to probes, which in turn can be used for detection of a genetic sequence. Such techniques have been described, for example, in U.S. Pat. Nos. 5,968,740 and 5,858,659. A probe also can be attached or affixed to an electrode surface for the electrochemical detection of nucleic acid sequences such as described by Kayem et al. U.S. Pat. No. 5,952,172 and by Kelley et al. (1999) Nucleic Acids Res. 27:4830-4837. 
     Various “gene chips” or “microarrays” and similar technologies are known in the art. Examples of such include, but are not limited to, LabCard (ACLARA Bio Sciences Inc.); GeneChip (Affymetric, Inc); LabChip (Caliper Technologies Corp); a low-density array with electrochemical sensing (Clinical Micro Sensors); LabCD System (Gamera Bioscience Corp.); Omni Grid (Gene Machines); Q Array (Genetix Ltd.); a high-throughput, automated mass spectrometry systems with liquid-phase expression technology (Gene Trace Systems, Inc.); a thermal jet spotting system (Hewlett Packard Company); Hyseq HyChip (Hyseq, Inc.); BeadArray (Illumina, Inc.); GEM (Incyte Microarray Systems); a high-throughput microarry system that can dispense from 12 to 64 spots onto multiple glass slides (Intelligent Bio-Instruments); Molecular Biology Workstation and NanoChip (Nanogen, Inc.); a microfluidic glass chip (Orchid Biosciences, Inc.); BioChip Arrayer with four PiezoTip piezoelectric drop-on-demand tips (Packard Instruments, Inc.); FlexJet (Rosetta Inpharmatic, Inc.); MALDI-TOF mass spectrometer (Sequnome); ChipMaker 2 and ChipMaker 3 (TeleChem International, Inc.); and GenoSensor (Vysis, Inc.) as identified and described in Heller (2002) Annu. Rev. Biomed. Eng. 4:129-153. Examples of “gene chips” or a “microarrays” are also described in U.S. Patent Publication Nos.: 2007/0111322; 2007/0099198; 2007/0084997; 2007/0059769 and 2007/0059765 and U.S. Pat. Nos. 7,138,506; 7,070,740 and 6,989,267. 
     In one aspect, “gene chips” or “microarrays” containing probes or primers homologous to a polynucleotide described herein are prepared. A suitable sample is obtained from the patient, extraction of genomic DNA, RNA, protein or any combination thereof is conducted and amplified if necessary. The sample is contacted to the gene chip or microarray panel under conditions suitable for hybridization of the gene(s) or gene product(s) of interest to the probe(s) or primer(s) contained on the gene chip or microarray. The probes or primers may be detectably labeled thereby identifying the sequence(s) of interest. Alternatively, a chemical or biological reaction may be used to identify the probes or primers which hybridized with the DNA or RNA of the gene(s) of interest. The genotypes or phenotype of the patient is then determined with the aid of the aforementioned apparatus and methods. 
     It is to be inferred without explicit recitation and unless otherwise intended, that when the present technology relates to a polypeptide, protein, polynucleotide or antibody, an equivalent or a biologically equivalent of such is intended within the scope of the present technology. 
     As used herein, the “administration” of an agent or drug to a subject or subject includes any route of introducing or delivering to a subject a compound to perform its intended function. Suitable dosage formulations and methods of administering the agents are known in the art. Route of administration can also be determined and method of determining the most effective route of administration are known to those of skill in the art and will vary with the composition used for treatment, the purpose of the treatment, the health condition or disease stage of the subject being treated and target cell or tissue. Non-limiting examples of route of administration include oral administration, vaginal, nasal administration, injection, topical application and by suppository. Administration includes self-administration and the administration by another. It is also to be appreciated that the various modes of treatment or prevention of medical conditions as described are intended to mean “substantial”, which includes total but also less than total treatment or prevention, and wherein some biologically or medically relevant result is achieved. 
     Administration can be effected in one dose, continuously or intermittently throughout the course of treatment. Methods of determining the most effective means and dosage of administration are known to those of skill in the art and will vary with the composition used for therapy, the purpose of the therapy, the target cell being treated and the subject being treated. Single or multiple administrations can be carried out with the dose level and pattern being selected by the treating physician. 
     As used herein, the term “animal” is used synonymously with “patient” or “subject” and refers to living multi-cellular vertebrate organisms, a category that includes, for example, mammals and birds. The term “mammal” includes both human and non-human mammals. Similarly, the term “subject” or “patient” includes both human and veterinary subjects, for example, humans, non-human primates, dogs, cats, sheep, mice, horses, and cows. 
     The term “crosslinking” refers to a method of chemically joining two or more molecules by a covalent bond. Crosslinking methods allow for the stabilization of molecular structures and the capture of molecular interactions within a cell so that they can be preserved and studied. Crosslinking may also involve “fixation” of a cell or tissue by which said cell or tissue is preserved from decay and degradation, thus preventing cell lysis or putrefaction. Non-limiting examples of fixatives include heat fixation and chemical fixation. Chemical fixatives include crosslinking fixatives such as aldehydes which cause covalent chemical bonds between proteins and molecules in a cell, precipitating fixatives such as alcohols that reduce the solubility of protein molecules and acetic acid, oxidizing agents that react with protein side chains and other biological molecules to allow formation of crosslinks, mercurial, picrates that react with histones and basic proteins to form crystalline picrates with amino acids, and hepes-glutamic acid buffer-mediated organic solvent protection effect. Crosslinking reagents appropriate for use with the disclosed methods include but are not limited to formaldehyde, paraformaldehyde, methylene blue with or without exposure to white light, sodium fluorescein, acridine orange, cisplatin, dimethylarsinic acid, potassium chromate, ultraviolet light, and lasers. 
     The term “acetylation” generally refers to the chemical reaction which attaches one or more acetyl functional groups (chemical formula CH 3 CO, sometimes referred to as the symbol “Ac”) to a chemical compound. Acetylation may also refer to the status of a particular chemical moiety with respect to its degree of modification with acetyl groups. “Deacetylation” is the removal of an acetyl group from a chemical compound. An acetylation reaction involves the replacement of the hydrogen atom of a hydroxyl group with an acetyl group to yield an acetate ester. Lysine amino acid residues are common targets for protein acetylation. For example, histones are acetylated and deacetylated on lysine residues of their N-terminal tails. Such histone acetylation and deacetylation reactions can be catalyzed by a class of enzymes with histone acetyltransferase (HAT) activity or histone deacetylase (HDAC) activity, respectively. HAT enzymes include but are not limited to the GNAT superfamily including Gcn5, SAGA, SLIK, STAGA, ADA, A2, Gcn5L, p300/CREB-binding protein associated factor (PCAF), Elp3, HPA2, and HAT1), the MYST family including MOZ (Monocytic Leukemia Zinc Finger Protein), Ybf2/Sas3, Sas2, Tip60, Esa1, MOF, MORF, and HBO1, the p300/CBP family including adenoviral E1A associated protein of 300 kDa (p300) and te CREB-binding protein (CBP), and other HATs such as steroid receptor coactivator 1 (SRC 1), ATF-2, and TAFII250. Acetyl-Coenzyme A is a common source of the acetyl group transferred to a target histone lysine residue by HAT enzymes. 
     Acetic anhydride (also known as ethanoic anhydride, chemical formula CH 3 CO 2 O) is a common acetylating agent. Acetic anhydride acetylation reactions can occur in the presence of an acid or base catalyst. Metal salts and triflates such as CoCl 2 , TiCl4-AgCLO 4 , TaCL 5 , TaCl 5 —SiO 2 , Ce(III) triflate, Sn(IV) porphyrine, Sc(OTf) 3 , MeSiOTf, In(OTf) 3 , Cu(OTf) 2 , Bi(OTf) 3 , bis(cyclopentadienyl) zirconium dichloride, I 2 , and 1,3,-dibromo-5,5-dimethylhydentoin, trichloroisocyanuric acid can be used in combination with acid anhydride. Equivalents of acetic anhydride include but are not limited to HAT enzymes, priopionic anhydride, deuterated acetic anhydride, acetic acid, acetyl chloride, acetyl-CoA, and formic anhydride. An equivalent of acetic anhydride has the property of being the donating source of an acetyl group to modify a histone lysine residue and/or catalyzing a histone lysine acetylation reaction. 
     The term “chromatin” refers to the complex of biological molecules found in the nucleus of a cell, comprising, e.g., DNA, protein (including histones), and RNA. Histones are alkaline proetins found in nuclei that can function to package the nucleic acid. The fundamental unit of chromatin is the nucleosome which comprises about 146 base pairs of DNA wrapped about 1.7 times in a left-handed turn around a protein octamer of two each of the core histones H3, H4, H2A and H2B. Alternatively, the octamer may be comprised of one or more variant histones including H3.3,centromeric H3 variant (cenH3, called also CENPA), H3.1, H3.2, TS H3.4, H3.5, H3.Y, H2A.X, H2A.Z, H2A.Z.2, H2A.B, H2A.L, H2A.P, H2A.1, H2B.1, H2A.J, H2B.1, H2B.W, H2B.Z, H2B.E. H1 and H5 linker histones are generally located between nucleosomes. Histones can control accessibility and expression of the region of DNA (or specific locus) around which they are bound or regions of DNA with which they associate. For example, histones with repressive modifications to their N-terminal tails tend to promote tightly compacted chromatin that prevents transcriptional machinery from accessing the DNA. In contrast, histones with modifications to their N-terminal tails that increase access to the DNA tend to promote chromatin with high levels of gene expression. In addition to histones and nucleic acids, chromatin may also comprise proteins that associate with DNA such as transcription machinery (including RNA polymerases), DNA replication machinery, and transcription factors or repressors. 
     The term “chromatin immunoprecipitation” (ChIP) refers to a method used to study the interaction between nucleic acids and proteins in the chromatin of a cell. This method can be combined with DNA detection techniques to determine whether specific proteins or protein modifications are associated with specific genomic regions, or loci. In general, the DNA, RNA, and proteins of chromatin are first crosslinked together to preserve their interactions. Next, the crosslinked chromatin is sheared to break the DNA crosslinked to proteins into fragments. Then an antibody directed to a protein of interest is incubated with the fragmented chromatin. The antibody may be directly bound to a magnetic bead or a secondary antibody bound to a magnetic bead may be added. Alternatively, a non-magnetic purification strategy such as an affinity tag may be used. Next, the antibody-bound chromatin fragments are immunoprecipitated by purification with a magnetic column or an alternate purification method. Finally, the protein is unlinked from the precipitated chromatin and the DNA is purified. Standard detection techniques can be used to identify the precipitated DNA such as PCR, quantitative PCR, and DNA sequencing. Further details for ChIP techniques and optimization can be found in Chapter 20 of Sambrook and Russell eds. (2012) Molecular Cloning: A Laboratory Manual, 4th edition, incorporated by reference herein. In some aspects, the disclosed methods utilize specialized ChIP techniques to capture three dimensional chromatin structures as they occur in living cells. These specialized ChIP methods include but are not limited to Chromatin Conformation Capture (3C), Circularized Chromosome Conformation Capture (4C), Carbon Copy Chromosome Conformation Capture (5C), ChIP-Loop, Hi-C, and Capture-C. These methods are reviewed in de Wit et al.  Genes and Development  2012 (26: 11-24), incorporated by reference herein. 
     The term “antibody” refers to a polyclonal, monoclonal, recombinant, or synthetic immunoglobulin molecule that specifically binds a target antigen. In one aspect, monoclonal antibodies are excluded. In another embodiment, polyclonal antibodies or other naturally occurring antibodies are excluded. The term includes intact immunoglobulin molecules, fragments or polymers of those immunoglobulin molecules, chimeric antibodies containing sequences from more than one species, class, or subclass of immunoglobulin, and human or humanized versions of immunoglobulin molecules or fragments thereof containing a least the idiotype of an immunoglobulin that specifically binds the target antigen. Target antigens relevant for the disclosed methods include but are not limited to the C-terminus of histone H3, H3 acetylated lysine residue 4, H3 acetylated lysine residue 9, and H3 acetylated lysine residue 14. Antibodies directed to the cleaved N-terminal tail and appropriate for use with the disclosed methods include but are not limited to Acetyl-Histone H3 (Lys9) Antibody (17H12L11), ABfinity Rabbit Monoclonal (ThermoFisher), Acetyl-Histone H3 (Lys9) Antibody (17HCLC), ABfinity Rabbit Oligoclonal (ThermoFisher), Acetyl-Histone H3 (Lys9) Antibody (2HCLC), Abfinity Rabbit Oligoclonal (ThermoFisher), Acetyl-Histone H3 (Lys14) Polyclonal Antibody (ThermoFisher), Acetyl-Histone H3 (Lys18) Polyclonal Antibody (ThermoFisher), Acetyl-Histone H3 (Lys9) Monoclonal Antibody (J.924.2) (ThermoFisher), Acetyl-Histone H3 (Lys9, Lys14) Polyclonal Antibody (ThermoFisher), Acetyl-Histone H3 (Lys4) Polyclonal Antibody (ThermoFisher), Acetyl-Histone H3 (Lys9) Polyclonal Antibody (ThermoFisher), Acetyl-Histone H3 (Lys9) Monoclonal Antibody (ThermoFisher), Acetyl-Histone H3 (Lys9, Lys14) Polyclonal Antibody (ThermoFisher), Anti-Histone H3 (acetyl K9) antibody—ChIP Grade (ab10812) (Abcam), Anti-Histone H3 (acetyl K9) antibody—ChIP Grade (ab4441) (abcam), Anti-Histone H3 (acetyl K18) antibody—ChIP Grade (ab1191) (abcam), Anti-Histone H3 (acetyl K14) antibody [EP964Y]—ChIP Grade (ab52946), and Anti-Histone H3 (acetyl K9) antibody [AH3-120]—ChIP Grade (ab12179) (abcam), or an equivalent of each thereof. An equivalent antibody is an antibody that has similar target reactivity (i.e. directed to an acetylated lysine residue in the N-terminal tail of histone H3), and can be used for chromatin immunoprecipitation. Equivalents also include antibodies with the same or similar target reactivity or idiotype that are conjucated to labels such as fluorochromes or epitope tags such as biotin. 
     The term “idiotype” refers to the portion of an immunoglobulin molecule that confers the molecule&#39;s ability to bind an antigen. The idiotype of an antibody is determined by the complementarity determining regions (CDRs) of the immunoglobulin variable domains (V L  and V H ). 
     Matrix metallopeptidase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. The sequence of the human protein is found under GenBank reference number NP_004985 and the mRNA encoding the protein is found under NM_004994. The murine counterpart is found under NP_038627 and the mRNA is found under NM_013599. In some aspects, the protein sequence of MMP-9 is (SEQ ID NO: 22), disclosed below. 
     Additional matrix metallopeptidases that are relevant for the disclosed methods include: Matrix metalloproteinases with potential histone tail cleavage activity include but are not limited to MMP1 (interstitial collagenase, human mRNA: NM_002421, NM_001145938; protein: NP_001139410, NP_002412), MMP2 (Gelatinase-A, 72 kDa gelatinase, human mRNA: NM_004530, NM_001127891, NM_001302508, NM_001302509, NM_001302510; protein: NP_001121363, NP_001289437, NP_001289438, NP_001289439, NP_004521), MMP3 (Stromelysin 1, human mRNA: NM_002422; protein: NP_002413), MMP7, (Matrilysin, Pumpl, human mRNA: NM_002423; protein: NP_002414), MMP8 (Neutrophil collagenase, human mRNA: NM_001304441, NM_001304442, NM_002424; protein: NP_001291370, NP_001291371, NP_002415), MMP10 (Stromelysin 2, human mRNA: NM_002425; protein: NP_002416), MMP11 (Stromelysin 3, human mRNA: NM_005940; protein: NP_005931, NP_005931.2), MMP12 (Macrophage metalloelastase, human mRNA: NM_002426; protein: NP_002417), MMP13 (Collagenase3, human mRNA: NM_002427; protein: NP_002418), MMP14 (MT1-MMP, human mRNA: NM_004995; protein: NP_004986), MMP15 (MT2-MMP, human mRNA: NM_002428; protein: NP_002419), MMP16 (MT3-MMP, human mRNA: NM_005941, NM_022564, NM_032297; protein: NP_005932), MMP17 (MT4-MMP, human mRNA: NM_016155; protein: NP_057239, NP_057239.4), MMP18 (Collagenase 4, xcol4,  Xenopus  collagenase), MMP19 (RASI-1, Stromelysin 4, human mRNA: NM_001032360, NM_001272101, NM_002429, NM_022790, NM_022792; protein: NP_001259030, NP_002420), MMP20 (Enamelysin, human mRNA: NM_004771; protein: NP_004762), MMP21 (XMMP, human mRNA: NM_147191; protein: NP_671724), MMP23A (CA-MMP), MMP23B (human mRNA: NM_006983, protein: NP_008914), MMP24 (MT5-MMP, human mRNA: NM_006690; protein: NP_006681), MMP25 (MT6-MMP, human mRNA: NM_004142, NM_022468, NM_022718; protein: NP_071913), MMP26 (Matrilysin-2, endometase, human mRNA: NM_021801; protein: NP_068573), MMP27 (MMP-22, C-MMP, human mRNA: NM_022122; protein: NP_071405), MMP28 (Epilysin, human mRNA: NM_001032278, NM_024302, NM_032950, protein: NP_001027449, NP_077278, NP_116568, NP_116568.1). 
     The term “inhibitor” refers to a molecule (often a small molecule) that acts to block a function of a desired target protein. An equivalent of an MMP-9 inhibitor is one that blocks MMP-9 function and/or its import to the nucleus. 
     The term “peptide” or “polypeptide” can be used to refer to a natural or synthetic molecule comprising two or more amino acids linked by the carboxyl group of one amino acid to the alpha amino group of another. The peptide is not limited by length; thus “peptide” can include polypeptides and proteins. 
     The term “peptidomimetic” refers to a mimetic of a peptide which includes some alteration of the normal peptide chemistry. Peptidomimetics typically enhance some property of the original peptide, such as increase stability, increased efficacy, enhanced delivery, increased half life, etc. 
     The term “aptamer” refers to an oligonucleic acid molecule that specifically binds to a target molecule. 
     As used herein, the term “small molecule” refers to a compound having a molecular weight of less than 1000 Daltons, and typically between 300 and 700 Daltons. The term may include monomers or primary metabolites, secondary metabolites, a biological amine, a steroid, or synthetic or natural, non-peptide biological molecule(s). In the context of targeted imaging probes that are small molecules, the small molecule can specifically bind the molecular or cellular target. 
     The term “specifically recognizes” or “specifically binds” refers to the recognition or binding of a molecule to a target molecule, such as an antibody to its cognate antigen, while not significantly binding to other molecules. Preferably, a molecule “specifically binds” to a target molecule with an affinity constant (Ka) greater than about 10 5  mol −1  (e.g., 10 6  mol −1 , 10 7  mol −1 , 10 8  mol −1 , 10 9  mol −1 , 10 10  mol −1 , 10 11  mol −1 , and 10 12  mol −1  or more) with the target molecule. 
     The term “subject” or “patient” refers to any individual who is the target of administration. The subject can be a vertebrate, for example, a mammal. Thus, the subject can be a human. The subject can be domesticated, agricultural, or zoo- or circus-maintained animals. Domesticated animals include, for example, mice, dogs, cats, rabbits, ferrets, guinea pigs, hamsters, pigs, monkeys or other primates, and gerbils. Agricultural animals include, for example, horses, mules, donkeys, burros, cattle, cows, pigs, sheep, and alligators. Zoo- or circus-maintained animals include, for example, lions, tigers, bears, camels, giraffes, hippopotamuses, and rhinoceroses. The term does not denote a particular age or sex. 
     By “treatment” and “treating” is meant the medical management of a subject with the intent to cure, ameliorate, stabilize, or prevent a disease, pathological condition, or disorder. This term includes active treatment, that is, treatment directed specifically toward the improvement of a disease, pathological condition, or disorder, and also includes causal treatment, that is, treatment directed toward removal of the cause of the associated disease, pathological condition, or disorder. In addition, this term includes palliative treatment, that is, treatment designed for the relief of symptoms rather than the curing of the disease, pathological condition, or disorder; preventative treatment, that is, treatment directed to minimizing or partially or completely inhibiting the development of the associated disease, pathological condition, or disorder; and supportive treatment, that is, treatment employed to supplement another specific therapy directed toward the improvement of the associated disease, pathological condition, or disorder. It is understood that treatment, while intended to cure, ameliorate, stabilize, or prevent a disease, pathological condition, or disorder, need not actually result in the cure, ameliorization, stabilization or prevention. The effects of treatment can be measured or assessed as described herein and as known in the art as is suitable for the disease, pathological condition, or disorder involved. Such measurements and assessments can be made in qualitative and/or quantitative terms. Thus, for example, characteristics or features of a disease, pathological condition, or disorder and/or symptoms of a disease, pathological condition, or disorder can be reduced to any effect or to any amount. 
     In some aspects, the diseases or conditions that can be treated by the disclosed methods include but are not limited to low bone mineral density (BMP), high BMP, osteoporosis, bone cancer, cancer that has metastasized to the bone, cancer-induced osteolysis, sepsis, rheumatoid arthritis, periodontitis, osteopetrosis, pycondysostosis, osteopoikilosis, meloreostosis, sclerosteosis, van Buchem&#39;s disease, LRP5 high bone mass, LRP4 high bone mass, craniometaphyseal dysplasia, Camurati-Engelmann disease, Ghosal syndrome, bone cancer, cancer metastasized to the bone, fluorosis, renal osteodystrophy, acromegaly, hepatitis C-associated osteosclerosis, myelofibrosis, mastocytosis, osseous tuberous sclerosis, Paget&#39;s disease, and SAPHO syndrome. The disclosed methods can also be used to treat or identify a cell or tissue in need of histone N-terminal tail cleavage. In some aspects, the disclosed methods can be used to treat or identify a subject in of increased, decreased, or inhibited osteoclastogenesis. 
     It is to be inferred without explicit recitation and unless otherwise intended, that when the present invention relates to a polypeptide, protein, polynucleotide or antibody, an equivalent or a biologically equivalent of such is intended within the scope of this invention. As used herein, the term “biological equivalent thereof” is intended to be synonymous with “equivalent thereof” when referring to a reference protein, antibody, fragment, polypeptide or nucleic acid, intends those having minimal homology while still maintaining desired structure or functionality. Unless specifically recited herein, it is contemplated that any polynucleotide, polypeptide or protein mentioned herein also includes equivalents thereof. In one aspect, an equivalent polynucleotide is one that hybridizes under stringent conditions to the polynucleotide or complement of the polynucleotide as described herein for use in the described methods. In another aspect, an equivalent antibody or antigen binding polypeptide intends one that binds with at least 70%, or alternatively at least 75%, or alternatively at least 80%, or alternatively at least 85%, or alternatively at least 90%, or alternatively at least 95% affinity or higher affinity to a reference antibody or antigen binding fragment. In another aspect, the equivalent thereof competes with the binding of the antibody or antigen binding fragment to its antigen under a competitive ELISA assay. In another aspect, an equivalent intends at least about 80% homology or identity and alternatively, at least about 85%, or alternatively at least about 90%, or alternatively at least about 95%, or alternatively 98% percent homology or identity and exhibits substantially equivalent biological activity to the reference protein, polypeptide or nucleic acid. In one aspect, a biological equivalent of an antibody means one having the ability of the antibody to selectively bind its epitope protein or fragment thereof as measured by ELISA or other suitable methods. Biologically equivalent antibodies include, but are not limited to, those antibodies, peptides, antibody fragments, antibody variant, antibody derivative and antibody mimetics that bind to the same epitope as the reference antibody. 
     A polynucleotide or polynucleotide region (or a polypeptide or polypeptide region) having a certain percentage (for example, 80%, 85%, 90%, or 95%) of “sequence identity” to another sequence means that, when aligned, that percentage of bases (or amino acids) are the same in comparing the two sequences. The alignment and the percent homology or sequence identity can be determined using software programs known in the art, for example those described in Current Protocols in Molecular Biology (Ausubel et al., eds. 1987) Supplement 30, section 7.7.18, Table 7.7.1. Preferably, default parameters are used for alignment. A preferred alignment program is BLAST, using default parameters. In particular, preferred programs are BLASTN and BLASTP, using the following default parameters: Genetic code=standard; filter=none; strand=both; cutoff=60; expect=10; Matrix=BLOSUM62; Descriptions=50 sequences; sort by=HIGH SCORE; Databases=non-redundant, GenBank+EMBL+DDBJ+PDB+GenBank CDS translations+SwissProtein+SPupdate+PIR. Details of these programs can be found at the following Internet address: ncbi.nlm.nih.gov. Sequence identity and percent identity were determined by incorporating them into clustalW. 
     A “composition” as used herein, intends an active agent, such as a compound as disclosed herein and a carrier, inert or active. The carrier can be, without limitation, solid such as a biotin, a bead or a resin, or liquid, such as phosphate buffered saline. 
     An “effective amount” is an amount sufficient to effect beneficial or desired results. An effective amount can be administered in one or more administrations, applications or dosages. Such delivery is dependent on a number of variables including the time period for which the individual dosage unit is to be used, the bioavailability of the therapeutic agent, the route of administration, etc. It is understood, however, that specific dose levels of the therapeutic agents disclosed herein for any particular subject depends upon a variety of factors including the activity of the specific compound employed, bioavailability of the compound, the route of administration, the age of the animal and its body weight, general health, sex, the diet of the animal, the time of administration, the rate of excretion, the drug combination, and the severity of the particular disorder being treated and form of administration. In general, one will desire to administer an amount of the compound that is effective to achieve a serum level commensurate with the concentrations found to be effective in vivo. These considerations, as well as effective formulations and administration procedures are well known in the art and are described in standard textbooks. Consistent with this definition and as used herein, the term “therapeutically effective amount” is an amount sufficient to treat a specified disorder or disease or alternatively to obtain a pharmacological response. 
     Modes for Carrying Out the Disclosure 
     This disclosure provides a method to identify to identify a polynucleotide fragment and or genomic locus bound to an H3 histone comprising a cleaved N-terminal tail (H3NT) in a cell, the method comprising, or alternatively consisting essentially of, or yet further consisting of the following steps: first crosslinking chromatin proteins including histones to the genomic DNA present in the cell by contacting the cell or a cell extract such as nuclear extract with an effective amount of methylene blue or an equivalent of methylene blue, subsequent to the cell having been exposed to white light or an equivalent of the white light. Methylene blue (chemical formula C 16 H 18 CIN 3 S) is also known as methylthionium is a medication and a dye. Methylene blue is commercially available from number of vendors, for example Tocris, Spectrum, and MD Supplies. Non-limiting examples of an equivalent to methylene blue include sodium fluorescein, acridine orange, cisplatin, dimethylarsinic acid, potassium chromate, ultraviolet light, and lasers. Most ChIP protocols utilize formaldehyde to crosslink proteins to DNA in vivo. However, because formaldehyde reacts with lysine E-amino side-chains, which likely precludes complete lysine acetylation by acetic anhydride, methylene blue is used as an alternative for cell fixation. As used herein any cell containing chromatin can be used in the assay, e.g., a plant cell or a eukaryotic cell, and cells that are in culture. Non-limiting examples of eukaryotic cells include animal cell, mammalian cells (e.g. any species, canine, feline, equine) or human cells. In one aspect the cell is a human cell. In some aspects, the cell is an osteoclast, osteoclast precursor, or a progenitor cell or stem cell capable of differentiation into an osteoclast. Cells capable of differentiation into an osteoclast include but are not limited to embryonic stem cells, induced pluripotent cells, hematopoietic stem cells, myeloid stem cells, granulocyte-macrophage colony forming unit (GM-CFU), monocyte precursor (CFU-M), progenitor cells, and pre-osteoclasts. 
     After the chromatin in the cell is cross-linked, it is isolated from the cell and the efficiency of crosslinking is confirmed by any appropriate method, e.g., by sodium dodecyl sulfate-chloroformisoamyl alcohol (SDS-CIA). Unmodified lysine residues are acetylated by treatment or contacting with an effective amount of acetic anhydride or other acetylation agent. The fragmented chromatin is then contacted in parallel with either (1) an effective amount of an H3 C-terminal control antibody or (2) an effective amount of a H3K14ac-specific antibody. Alternatively, the chromatin may be contacted with another antibody specific for a lysine residue N-terminal (upstream) of the cleavage site of interest such as an H3K4ac or H3K9ac antibody. In another aspect, a mixture of two or more of H3K14ac, H3K4ac, and H3K9ac antibodies is used to enrich for uncleaved H3. The two parallel antibody-bound fragmented chromatin samples are then selectively enriched by immunoprecipitation. The antibody is a monoclonal or a polyclonal antibody. In one aspect, use of the H3 C-terminal tail antibody is performed in parallel with the normalization control. H3 N-terminal tail-cleaved regions are identified by the significant reduction in H3K14ac enrichment relative to control, e.g., as determined by quantitative PCR (qPCR) or NextGen DNA sequencing analysis. 
     Also provided herein is a method for identification and examination of genetic loci bound by H3 with N-terminal tail-cleaved regions. First, cells are fixed with methylene blue or an equivalent thereof to crosslink chromatin after brief exposure to white light. It should be noted that most ChIP protocols utilize formaldehyde to crosslink proteins to DNA in vivo. However, because formaldehyde reacts with lysine E-amino side-chains, which likely precludes complete lysine acetylation by acetic anhydride, methylene blue was used as an alternative for cell fixation. Chromatin was isolated and the efficiency of crosslinking was confirmed by sodium dodecyl sulfate-chloroformisoamyl alcohol (SDS-CIA). Fragmented chromatin was then treated with acetic anhydride to completely acetylate all unmodified lysine residues in vitro. ChIPac using an H3K14ac-specific antibody selectively enriched H3 N-terminal tail-containing chromatin and simultaneously excluded chromatin lacking the H3 N-terminal tail. ChIPac using an H3 C-terminal tail antibody was performed in parallel as the normalization control. H3 N-terminal tail-cleaved regions were identified by the significant reduction in H3K14ac enrichment relative to control as determined by quantitative PCR (qPCR) or NextGen sequencing analysis. 
     This method can also be used to identify and monitor other histone tail proteolysis processes. For example, the cysteine protease capthepsin L has been reported to cleave H3 in murine embryonic stem cells at several cleavage sites, including between alanine residue 21 and threonine residue 22 and between lysine residue 27 and serine residue 28. Because these cleavage sites are downstream (i.e. closer to the C-terminus of H3) of the recognition site for the detection antibodies used herein (i.e. H3K14, H3K9, and/or H3K4), the methods disclosed herein can be used to detect the location of capthepsinL cleaved histone H3 in the genome of a cell. As long as the detection antibody is directed to an acetylated residue upstream (i.e. closer to the N-terminus) of the putative H3 tail cleavage site, a cleaved histone genome binding location can be identified through the disclosed methods. Thus, the disclosed methods can be used detect the genomic loci of histone H3 cleaved at the following sites: alanine residue 21, arginine residue 26, or alanine residue 31 as reported in embryonic stem cells; between lysine 23 and alanine 24 or between lysine 27 and serine 28 as reported in chickens and catalyzed by the glutamate dehydrogenase enzyme; between alanine 21 and threonine 22 as reported in  Saccharomyces cerevisiae  and catalyzed by the purified vacuolar protease B enzyme; and between leucine 20 and alanine 21. In other aspects, this method can be used to identify and monitor lysis of other histone tails such as histone H2A, H2B, and H4 using antibodies specific to the cleaved portion of the H2A, H2B, or H4 in conjunction with antibodies to the C-terminal portion of these histones. 
     Thus, in one aspect, provided herein is a method to identify and examine H3 N-terminal tail cleaved regions of a histone, the method comprising, or alternatively consisting essentially of, or yet further consisting of: a) contacting a cell containing chromatin with methylene blue or an equivalent thereof after exposure to white light or an equivalent of the white light to crosslink proteins in the cell; b) isolating the chromatin, c) acetylating all unmodified lysine residues by contacting the chromatin with acetic anhydride; d) conducing ChIPac with an H3 C-terminal tail antibody; and e) identifying H3 N-terminal tail-cleaved regions by detecting reduction in H3K14ac enrichment relative to a control. 
     In some aspects of the method, step e. is performed by a method comprising, or alternatively consisting essentially of, or yet further consisting of, quantitative PCR (qPCR) or NextGen sequencing analysis. 
     In another aspect, provided herein is a method to identify a polynucleotide fragment bound to an H3 histone comprising a cleaved N-terminal tail (H3NT) in a cell, the method comprising: a) crosslinking the genomic DNA of the cell to the histones of the cell, thereby producing crosslinked chromatin; b) generating fragments of the crosslinked chromatin; c) acetylating all unmodified lysine residues in the histones by contacting the fragmented, crosslinked chromatin with acetic anhydride or an equivalent thereof, d) conducting parallel chromatin immunoprecipitations on the acetylated chromatin produced in step c). with (1) an H3 C-terminal tail control antibody and (2) one or more antibodies directed to acetylated lysine residues in the cleaved region of the H3NT; and e) identifying the polynucleotide fragment bound to an H3NT by detecting reduction in polynucleotide fragment enrichment with the one or more antibodies directed to acetylated lysine residues in the cleaved region relative to polynucleotide fragment enrichment with the H3 C-terminal tail control antibody. 
     In some aspects of the method, step a) is performed by fixation with methylene blue or an equivalent thereof. 
     In some aspects of the method, step b) is performed by sonication, enzymatic fragmentation, or an equivalent of each thereof. 
     In some aspects of the method, the one or more antibodies directed to acetylated lysine residues in the cleaved region of the H3NT in step d)(2) are selected from an an H3K4ac antibody, an H3K9ac antibody, and an H3K14ac antibody. 
     In some aspects of the method, the one or more antibodies directed to acetylated lysine residues in the cleaved region of the H3NT in step d)(2) is an H3K14ac antibody. 
     In some aspects of the method, step e) is performed by a method comprising quantitative PCR (qPCR) or NextGen sequencing analysis. 
     In other aspects, the method further comprises identifying a subject appropriate for therapeutic treatment with MMP-9. 
     In other aspects, the method further comprises identifying genetic loci at which a matrix metalloproteinase or other histone cleavage enzyme cleaves an H3 N terminal tail. Matrix metalloproteinases with potential histone tail cleavage activity include MMP1 (interstitial collagenase), MMP2 (Gelatinase-A, 72 kDa gelatinase), MMP3 (Stromelysin 1), MMP7, (Matrilysin, Pump 1), MMP8 (Neutrophil collagenase), MMP9 (Gelatinase-B, 92 kDa gelatinase), MMP10 (Stromelysin 2), MMP11 (Stromelysin 3), MMP12 (Macrophage metalloelastase), MMP13 (Collagenase3), MMP14 (MTI-MMP), MMP15 (MT2-MMP), MMP16 (MT3-MMP), MMP17 (MT4-MMP), MMPP18 (Collagenase 4, xcol4,  Xenopus  collagenase), MMP19 (RASI-1, Stromelysin 4), MMP20 (Enamelysin), MMP21 (XMMP), MMP23A (CA-MMP), MMP23B, MMP24 (MT5-MMP), MMP25 (MT6-MMP), MMP26 (Matrilysin-2, endometase), MMP27 (MMP-22, C-MMP), MMP28 (Epilysin). 
     Also provided is a kit for identifying a polynucleotide fragment bound to an H3 histone comprising a cleaved N-terminal tail (H3NT) in a cell, the kit comprising: a) acetic anhydride or an equivalent thereof, b) an H3 C-terminal tail control antibody; c) a full length H3 N-tail detection antibody directed to an acetylated lysine residue; and d) instructions for use. In some embodiments, the full length H3 N-tail detection antibody is a H3K14ac antibody. In other embodiments, the antibody is an H3K4ac antibody or an H3K9ac antibody. In some embodiments, a mixture of one or more of H3K14ac antibody, H3K4ac antibody, and H3K9ac antibody are used to detect the full length acetylated H3 N-terminal tail. In some aspects, the kit may further comprise buffers, negative control antibodies, enzymes, methylene blue, and/or other reagents necessary to perform chromatin immunoprecipitation. The standard reagents necessary to perform chromatin immunoprecipitation, qPCR, and DNA seq are well known in the art. 
     Also provided is a method to modulate H3NT proteolysis during osteoclastogenesis in a cell, comprising, or alternatively consisting essentially of, or yet further consisting of, modulating the activity of MMP-9 in the cell. In one aspect, H3NT proteolysis is increased by increasing MMP-9 activity in the cell. In another aspect, the H3NT proteolysis is decreased by depletion or inhibit of MMP-9 activity in the cell. Diseases or pathological conditions associated with over- or under-osteoclastogenesis also can be treated by administering to a subject in need thereof an effective amount of the MMP-9 promoting or inhibiting agent. Agents that activate or promote MMP-9 activity include recombinant or isolated MMP-9 protein and epidermal growth factor has been shown to increase the expression and activity of MMP-9 (see WO 2002/045740). In some aspects, the agent is selected from recombinant MMP-9, recombinant MMP-9 modified to include nuclear localization signals, a histone acetyltransferase enzyme with H3K18 specificity, and gene therapy with a polynucleotide encoding MMP-9. Agents that inhibit or decrease MMP-9 activity are known in the art, e.g., as described in US Patent Appl. No. 2017/0015647; 2013/0064878; and 2011/00114186, and incorporated herein by reference. In some aspects, the agent is selected from MMP-9 shRNA, a mesenchymal stem cell expressing MMP-9 shRNA, a CBP/p300 inhibitor, an MMP-9 inhibitor, or a metalloprotease inhibitor. In some aspects, inhibitors appropriate for use with the disclosed methods include but are not limited to inhibitors of MMP-9 such as 2-(N-Benzyl-4-methoxyphenylsulfonamido)-5-((diethylamino)methyl)-N-hydroxy-3-methylbenzamide, actinonin, marimastat, MMP Inhibitor V, Batimastat, Chlorhexidine, dihydrochloride, GM 6001, MMP Inhibitor II, cis-ACCP, SB-3CT, 4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid, keracyanin chloride, MMP2/MMP-9 Inhibitor I, MMP-2/MMP-9 Inhibitor II, MMP-9 Inhibitor I, MMP-9/MMP-13 inhibitor I, MMP-9/MMP-13 inhibitor II, MMP-2/MMP-9 Inhibitor V, CP 471474, Ageladine A, TFA, or an equivalent of each thereof. The above-listed MMP inhibitors are available from Abcam or Santa Cruz Biotech. 
     Also provided herein is a method to modulate H3NT proteolysis in a cell, comprising modulating the activity of MMP-9 in the cell. In some aspects, H3NT proteolysis is increased by increasing MMP-9 activity in the nucleus of the cell. In further aspects, MMP-9 activity is increased by increasing nuclear localization of MMP-9, increasing acetylation of H3K18 residues, and/or overexpression of MMP-9. In other aspects, H3NT proteolysis is decreased by depletion or inhibition of MMP-9 activity in the cell. In further aspects, MMP-9 activity is decreased by knockdown of MMP-9 mRNA, treatment with CBP/p300 inhibitor, and/or treatment with a metalloprotease inhibitor. Knockdown of MMP-9 mRNA can comprise treatment with MMP-9 shRNA and/or contacting the cell with an effective amount of a mesenchymal stem cell expressing MMP-9 shRNA. 
     In the above methods, a cell is a prokaryotic or a eukaryotic cell, and when an eukaryotic cell can be a mammalian cell, e.g., a mouse, canine, feline, ovine, simian or a human cell. In the above methods, a cell may be an osteoclast, an osteoclast precursor cell, or a stem or progenitor cell that can be differentiated into an osteoclast. 
     Also provided herein is a method to attenuate osteoclast formation and/or differentiation in a subject, comprising, or alternatively consisting essentially of, or yet further consisting of, administering to the subject an effective amount of a MMP-9 agent, inhibitor, or activator to the subject. In several aspects, the subject is a mammal, e.g., a mouse, a canine, a feline, an ovine, a simian or a human patient. These methods can be used therapeutically or in veterinary applications, or alternatively, as an animal model to assay for new therapies or treatments. The agents can be used alone or in combination with other known therapies. 
     Also provided herein is a method of treating a subject with low bone mineral density, administering an agent or inhibitor that decreases or inhibits the activity of MMP-9 in the subject. In several aspects, the subject is a mammal, e.g., a mouse, a canine, a feline, an ovine, a simian or a human patient. These methods can be used therapeutically or in veterinary applications, or alternatively, as an animal model to assay for new therapies or treatments. The agents can be used alone or in combination with other known therapies. In some aspects, the subject has a bone related disease or condition selected from osteoporosis, bone cancer, cancer that has metastasized to the bone, cancer-induced osteolysis, sepsis, rheumatoid arthritis, and periodontitis. Agents that inhibit or decrease MMP-9 activity are known in the art, e.g., as described in US Patent Appl. No. 2017/0015647; 2013/0064878; and 2011/00114186, and incorporated herein by reference. In some aspects, the agent is selected from MMP-9 shRNA, a mesenchymal stem cell expressing MMP-9 shRNA, a CBP/p300 inhibitor, an MMP-9 inhibitor, or a metalloprotease inhibitor. In some aspects, inhibitors appropriate for use with the disclosed methods include but are not limited to inhibitors of MMP-9 such as 2-(N-Benzyl-4-methoxyphenyl sulfonamido)-5-((diethylamino)methyl)-N-hydroxy-3-methylbenzamide, actinonin, marimastat, MMP Inhibitor V, Batimastat, Chlorhexidine, dihydrochloride, GM 6001, MMP Inhibitor II, cis-ACCP, SB-3CT, 4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid, keracyanin chloride, MMP2/MMP-9 Inhibitor I, MMP-2/MMP-9 Inhibitor II, MMP-9 Inhibitor I, MMP-9/MMP-13 inhibitor I, MMP-9/MMP-13 inhibitor II, MMP-2/MMP-9 Inhibitor V, CP 471474, Ageladine A, TFA, or an equivalent of each thereof. The above-listed MMP inhibitors are available from Abcam or Santa Cruz Biotech. 
     Also provided herein is a method of treating a subject with high bone mineral density, comprising administering an agent that increases the activity of MMP-9 in the subject. In several aspects, the subject is a mammal, e.g., a mouse, a canine, a feline, an ovine, a simian or a human patient. These methods can be used therapeutically or in veterinary applications, or alternatively, as an animal model to assay for new therapies or treatments. The agents can be used alone or in combination with other known therapies. In some aspects, the subject has a bone related disease or condition selected from osteopetrosis, pycondysostosis, osteopoikilosis, meloreostosis, sclerosteosis, van Buchem&#39;s disease, LRP5 high bone mass, LRP4 high bone mass, craniometaphyseal dysplasia, Camurati-Engelmann disease, Ghosal syndrome, bone cancer, cancer metastasized to the bone, fluorosis, renal osteodystrophy, acromegaly, hepatitis C-associated osteosclerosis, myelofibrosis, mastocytosis, osseous tuberous sclerosis, Paget&#39;s disease, and SAPHO syndrome. Agents that increase MMP-9 activity in a cell include, for example, recombinant or isolated MMP-9 protein and epidermal growth factor (see WO 2002/045740). In some aspects, the agent is selected from recombinant MMP-9, recombinant MMP-9 modified to include nuclear localization signals, a histone acetyltransferase enzyme with H3K18 specificity, and gene therapy with a polynucleotide encoding MMP-9. 
     Also provided is method to modulate H3NT proteolysis during osteoclastogenesis in a cell, comprising, or alternatively consisting essentially of, or yet further consisting of, modulating the activity of MMP-9 in the cell. In one aspect, H3NT proteolysis is increased by increasing MMP-9 activity in the cell. Agents that increase MMP-9 activity in a cell include, for example, recombinant or isolated MMP-9 protein and epidermal growth factor (see WO 2002/045740). In another aspect, the H3NT proteolysis is decreased by depletion or inhibit of MMP-9 activity in the cell. Agents that inhibit or decrease MMP-9 activity are known in the art, e.g., as described in US Patent Appl. No. 2017/0015647; 2013/0064878; and 2011/00114186, and incorporated herein by reference. Cells that are suitably treated with the agents include without limitation a eukaryotic cell, a mammalian cell, e.g. a human cell, a equine cell, a canine cell, or a feline cell, an osteoclast, an osteoclast precursor, or a progenitor cell or stem cell capable of differentiation into an osteoclast. Cells capable of differentiation into an osteoclast include but are not limited to embryonic stem cells, induced pluripotent cells, hematopoietic stem cells, myeloid stem cells, granulocyte-macrophage colony forming unit (GM-CFU), monocyte precursor (CFU-M), progenitor cells, and pre-osteoclasts. 
     Descriptive Embodiments 
     Applicant discloses herein that MMP-9 is a novel H3NT protease required for H3NT proteolysis observed during osteoclastogenesis. This data demonstrate that RANKL-induced differentiation of primary mouse OCP cells facilitates the progressive nuclear accumulation and activity of MMP-9 concomitant with increased H3NT proteolysis. By applying Applicant&#39;s novel ChIPac-Seq method, App licant determined that many canonical osteoclastogenic genes are selectively targeted for H3NT proteolysis during osteoclastogenesis. Depletion of MMP-9 or inhibition of MMP-9 activity abrogated H3NT proteolysis concurrent with impaired osteoclastogenic gene activation and defective osteoclast differentiation. Applicant&#39;s data support a model whereby RANKL signaling induces MMP-9-dependent H3NT proteolysis at osteoclastogenic genes to regulate their expression necessary for proficient osteoclast differentiation. Consistent with this, it has been demonstrated that chemical inhibition of MMP-9 activity in vivo attenuates osteoclast formation in juvenile mouse clavaria and MMP-9−/− mice display delayed long bone development and defective bone fracture repair (Vu et al. 1998; Colnot et al. 2003; Cackowski et al. 2010; Franco et al. 2011). 
     Despite increasing evidence supporting H3NT proteolysis in epigenetic regulation, advances in the field have been significantly impeded by the lack of a method to define and investigate genomic regions targeted for H3NT proteolysis in mammalian cells. Applicant addresses this need by providing a ChIP of acetylated chromatin (ChIPac) method as a general approach to map and examine H3NT-cleaved regions. Since H3K14 resides within the H3NT-cleaved fragment and primarily exists in either an unmodified or acetylated state in mammals, an H3K14ac-specific antibody was used to selectively immunoprecipitate H3NT-containing nucleosomes from artificially acetylated crosslinked chromatin. ChIPac-Seq in MMP-9 depleted OCP cells that lack H3NT proteolysis validated the proficiency of the H3K14ac antibody to capture all nucleosomes, as the H3K14ac enrichment patterns were nearly identical to H3CT control. Furthermore, ChIPac-Seq in control 3-day OCP-induced cells that exhibit limited H3NT proteolysis identified a small number of genomic regions displaying significant reductions in H3K14ac enrichment, indicative of nucleosomes lacking the H3NT. Inhibition of H3NT proteolysis in 3-day OCP-induced cells rescued H3K14ac enrichment confirming that ChIPac with an H3K14ac-specific antibody identified sites selectively targeted for H3NT proteolysis during osteoclastogenesis. These results validate the ChlPac-Seq method to identify H3NT-cleaved sites that, most likely, can be utilized in other eukaryotic model systems. Application of ChIPac-Seq in this study resulted in the first demonstration of selective H3NT proteolysis at specific genomic sites during mammalian differentiation. 
     It was previously reported that proteolysis of the H3NT at gene promoters is directly correlated to transcriptional activation during yeast sporulation (Santos-Rosa et al. 2009). In this report, ChIPac-Seq similarly identified H3NT-cleaved regions surrounding the TSS of specific protein coding genes during osteoclastogenesis. Whereas H3NT proteolysis occurred at yeast promoters, mouse preosteoclasts displayed H3NT-cleaved regions that partitioned as those that were promoter-specific (P), coding region-specific (CR) or both (P+CR). The functional significance for these differences, if any, is unclear. Regardless of H3NT cleavage location (P, CR or P+CR), the majority of genes targeted for H3NT proteolysis during osteoclast differentiation displayed concomitant significant changes in expression. H3NT proteolysis correlated to transcriptional activation for &gt;82% of these genes during osteoclastogenesis, similar to results in yeast, supporting the direct role of H3NT cleavage in gene activation. Several H3NT-cleaved genes were repressed and many others exhibited little difference in expression during differentiation, suggesting that H3NT proteolysis regulates activation of specific groups of genes in a context-dependent manner. In the context of RANKL signaling in OCP cells, the activation of a group of canonical osteoclastogenic genes necessary for osteoclast differentiation was directly correlated to the selective H3NT proteolysis near their TSSs. Inhibition of H3NT proteolysis at these sites significantly impaired their activation, despite continuous RANKL signaling, resulting in defective osteoclast differentiation. Therefore, Applicant postulated that distinct signaling cues induce selective H3NT proteolysis to facilitate the rapid activation of specific developmental genes necessary for proficient differentiation. 
     Biochemical purification of preosteoclast nuclear extracts identified MMP-9 as a novel H3NT protease. Detailed investigation confirmed that MMP-9 is the principal histone protease in preosteoclasts that selectively cleaves the H3NT in vitro and in cells. Applicant&#39;s results strongly support a model whereby MMP-9 directly cleaves the H3NT to activate genes. Without being bound by theory, Applicant does not exclude the possibility that MMP-9 activity may also regulate unknown factors necessary to facilitate H3NT proteolysis and/or gene activation during osteoclastogenesis. However, these results demonstrate proteolysis of histones by a metalloproteinase that, therefore, expands the spectrum of histone proteases beyond the canonical serine and cysteine protease families (Dhaenens et al. 2015). Also without being bound by theory, these results suggest histone proteolysis by the remaining 22 MMPs. The primary P1 site of the yeast PRB1 serine protease and mouse Cathepsin cysteine proteases is H3A21 (Duncan et al. 2008; Duarte et al. 2014; Khalkhali-Ellis et al. 2014; Xue et al. 2014). In contrast, in silico analysis predicted H3K18 as the primary P1 site for MMP-9, which was confirmed experimentally. The MMP-9 and PRB1 endopeptidases generate a single major H3NT-cleaved product whereas Cathepsins generate progressively shorter H3 forms after T22 due to their additional aminopeptidase activity. These enzymatic and substrate differences support MMP-9 as the founding member of a novel class of H3K18 proteases. 
     Based on Applicants&#39; findings and previous reports, Applicant looked to determine if specific classes of H3NT proteases are utilized in a context-dependent manner to facilitate distinct epigenetic mechanisms due to their particular H3NT proteolytic activities. In the context of mESC differentiation, the Cathepsin L H3A21 protease accumulates in the nucleus and is required for H3NT proteolysis (Duncan et al. 2008). The resulting H3Δ22 cleaved product impeded CBX7 chromodomain binding to H3K27me3 in vitro suggesting that proteolysis of H3 aa1-21 reduces the affinity of repressive H3K27me-binding proteins/complexes, thereby, facilitating gene activation in differentiating mESCs. This putative mechanism of epigenetic regulation may be conserved for H3A21 proteases but is less likely to apply to H3K18 proteases since an H3A18 peptide did not impair H3K27me3-CBX7 binding in vitro (Duncan et al. 2008). Although the primary mechanism of epigenetic regulation by H3K18 proteases remains unknown, the contrasting H3NT activities and epigenetic regulatory mechanisms observed between MMP-9 and Cathepsins may explain why each protease is selectively utilized during differentiation of distinct cell types. 
     During osteoclast differentiation, MMP-9 accumulates in the nucleus concomitant with gelatinase activity and H3NT proteolysis. Consistent with the disclosed results, increasing evidence demonstrates MMP-9 nuclear localization and activity in specific cell types and under certain physiological conditions (Mannello and Medda 2012). The mechanisms that facilitate MMP-9 nuclear translocation remain unknown but the lack of an NLS support the necessity of unidentified MMP-9-associated factors for transport. Applicant&#39;s results demonstrate that progressive MMP-9 nuclear accumulation during osteoclastogenesis is directly proportional to the extent of gelatinase activity and H3NT proteolysis. Robust gelatinase activity and H3NT proteolysis were not observed prior to preosteoclast formation, despite nuclear localization of the MMP-9 active form shortly after RANKL treatment, suggesting that a threshold of MMP-9 abundance regulates its nuclear protease activity. Furthermore, Applicant&#39;s results support H3K18 acetylation as a key regulator of MMP-9 activity. The specific acetylation of H3K18 was necessary and sufficient for MMP-9 H3NT proteolysis of nucleosome substrates in vitro and, in preosteoclasts, the sites and extent of H3NT cleavage were directly proportional to the level of acetylated H3K18. These results demonstrating that H3NT proteolysis is dependent on CBP/p300 activity, but not other canonical H3K18 acetyltransferases, support CBP/p300 as a central regulator of H3K18ac-dependent H3NT proteolysis. 
     It was recently reported that CBP recruitment and histone acetylation at the Nfatc1 promoter were directly correlated to Nfatc1 transcriptional activation during osteoclastogenesis, further supporting the necessity of CBP/p300-mediated H3K18 acetylation in regulating H3NT proteolysis and gene activation (Park-Min et al. 2014). Importantly, these results demonstrate that the targeted acetylation of H3K18 at the H3NT cleavage sites of Nfatc1, Lif and Xpr1 was insufficient to induce their expression during osteoclastogenesis, supporting H3NT cleavage as a prerequisite for their activation. Without being bound by theory, modulation of H3NT proteolysis by H3K18 acetylation is a conserved regulatory mechanism of many H3NT proteases, as Cathepsin L activity was also augmented by H3K18ac in vitro (Duncan et al. 2008). 
     Previous reports demonstrated that other histone modifications also regulate the activity of H3A21 proteases. Methylation of H3K27 augmented Cathepsin L activity in vitro whereas acetylated H3K23 abrogated H3 proteolysis in a dominant manner (Duncan et al. 2008). Similarly, H3K4me3 suppressed H3NT proteolysis in yeast consistent with the absence of H3K4me3 in the cleaved H3NT peptides isolated from differentiating mESCs (Santos-Rosa et al. 2009). In contrast to these reports, Applicant&#39;s results demonstrate that H3K4 methylation, H3K23 acetylation and H3K27 methylation are insufficient to regulate MMP-9 activity in vitro. These findings suggest that distinct H3NT proteases are differentially regulated by a specific “histone code” that stimulates or inhibits their activity (Strahl and Allis 2000). This may explain, in part, why only limited H3NT proteolysis is observed during differentiation and why MMP-9-dependent H3NT proteolysis is detected at only a small number of defined regions during osteoclastogenesis. 
     The H3NT proteases generate a cleaved H3 product that is transiently retained in chromatin during yeast sporulation and mESC differentiation (Duncan et al. 2008; Santos-Rosa et al. 2009). Although the rapid H3NT proteolysis identified at yeast promoters was insufficient for gene activation, the cleaved H3 facilitated subsequent nucleosome eviction at these promoters, by unknown mechanisms, concomitant with their activation. These findings suggest the similar requirement of cleaved H3-mediated nucleosome eviction for proficient gene activation during mammalian differentiation. However, Applicants&#39; results demonstrate that cleaved H3 is retained within chromatin of differentiated osteoclasts and that robust activation of the H3NT-cleaved genes examined during osteoclastogenesis is independent of nucleosome eviction or histone replacement near their TSSs. While retention of cleaved H3 is observed in chromatin of terminally differentiated and senescent cells, the functional significance between retention and eviction/replacement of cleaved H3, as observed in differentiating mouse and human ESCs, remains unknown (Duncan et al. 2008; Asp et al. 2011; Duarte et al. 2014; Vossaert et al. 2014). 
     Experimental Details 
     Proteolysis of the Histone H3 N-Terminal Tail During Osteoclastogenesis 
     Since the epigenetic mechanisms that regulate mammalian osteoclastogenesis are largely unknown, an established ex vivo cell model was used to examine possible histone PTM changes during differentiation. Primary osteoclast precursor (OCP) cells derived from adult mouse long bone were cultured with the osteoclastogenic factor RANKL to induce synchronous osteoclast differentiation (An et al. 2014). As shown in  FIG. 1A , nearly all 3-day OCP-induced cells were mononuclear preosteoclasts that fuse to form large multinuclear osteoclasts by day 5. Nuclei were isolated from OCP-induced cells at these time points and chromatin was extracted. Western blot analysis revealed an unexpected differentiation-dependent fast-migrating H3 band in chromatin of preosteoclasts with elevated levels detected in osteoclasts ( FIG. 1B ). Because an H3 C-terminal (H3CT) antibody was used in the Western blot analysis, the observed fast-migrating H3 band indicates specific proteolysis of the H3 N-terminal (H3NT). Fast-migrating bands of other nucleosome core histones were not observed demonstrating the selective, but limited, proteolysis of the H3NT during osteoclastogenesis ( FIG. 1B ). 
     MMP-9 is the Principal H3NT Protease in Preosteoclasts 
     To identify the protease responsible for H3NT cleavage observed in preosteoclasts, nuclear extracts from 3-day OCP-induced cells were fractionated by a series of chromatography steps ( FIG. 1C ). An in vitro H3NT cleavage assay was developed using a recombinant H3 (rH3) substrate and Western blot analysis with the H3CT antibody to track and isolate nuclear fractions containing H3NT protease activity. Initial fractionation by P11 chromatography revealed that H3NT protease activity was largely restricted to two sequential fractions, BC400 and BC500, suggesting that a single protease cleaves the H3NT in preosteoclasts. These fractions were combined and fractionated on a Q-sepharose column where, again, H3NT protease activity was largely restricted to two sequential fractions, BR100 and BR200. The fractions were combined for glycerol gradient sedimentation resulting in the final purification of fractions (#3-5) containing H3NT protease activity. These purified fractions were initially incubated with different protease inhibitors to identify the family of proteases responsible for H3NT cleavage. Various serine and cysteine protease inhibitors failed to inhibit H3NT protease activity, which was highly unexpected as these families were reported to proteolyze the H3NT in yeast and mice, respectively ( FIG. 1D ) (Duncan et al. 2008; Khalkhali-Ellis et al. 2014; Xue et al. 2014). Further screening demonstrated that only metalloproteinase inhibition could abrogate H3NT cleavage activity ( FIG. 1E ). Consistent with these results, proteomic analysis of the purified fractions revealed that matrix metalloproteinase 9 (MMP-9) was the predominant of the four known proteases identified ( FIG. 1F ). In vitro H3NT cleavage assays using these recombinant proteases demonstrated that only rMMP-9 possessed H3NT protease activity ( FIG. 1G ). The purified fractions and rMMP-9 displayed similar H3NT protease activities for octamer and nucleosome array substrates as well as for H3.1, H3.2 and H3.3 substrates ( FIGS. 8A-8B ). Incubation of the purified fractions with a selective MMP-9 inhibitor abolished H3NT proteolysis confirming that MMP-9 activity is required for H3NT cleavage in vitro ( FIG. 1E ). These findings identify MMP-9 as a novel H3NT protease and the principal H3NT protease in preosteoclasts. 
     MMP-9 Activity is Required for H3NT Proteolysis During Osteoclastogenesis 
     Matrix metalloproteinases are a large diverse family of zinc-dependent endopeptidases that function to remodel the pericellular space via proteolysis of extracellular matrix proteins (Nagase et al. 2006). MMP-9 and MMP-2 comprise the gelatinase sub-family of MMPs and are differentially expressed in osteoclasts and osteoblasts, respectively. MMP-9 is synthesized as an inactive/latent 92-kDa proenzyme and subsequently converted to an 82-kDa active form by proteolysis of its inhibitory N-terminal prodomain. Since MMP-9 is a secretory protein, Applicants&#39; results demonstrating nuclear MMP-9 activity were unexpected. To address this discrepancy, MMP-9 localization dynamics were examined during osteoclastogenesis. Western blot analysis demonstrated that MMP-9 was absent in control OCP cells but both the pro- and active-forms of MMP-9 were detected in the nuclear compartment of 1-day OCP-induced cells ( FIG. 2A  and  FIG. 9A ). MMP-9 protein abundance was maximal by day 3 post-induction and was sustained in 5-day OCP-induced cells. Immunofluorescence microscopy confirmed the progressive nuclear accumulation of MMP-9 in OCP-induced cells ( FIG. 9B ). Gelatin zymography was performed using nuclear extracts isolated from OCP-induced cells to assess nuclear-specific MMP-9 gelatinase activity. Nuclear gelatinase activity mirrored the progressive nuclear accumulation of MMP-9 during osteoclastogenesis ( FIG. 2B ). These results indicate that maximal MMP-9 nuclear abundance and activity observed in 3-day OCP-induced cells directly correlate with H3NT proteolysis. To test the dependence of H3NT cleavage on MMP-9 during osteoclastogenesis, OCP cells were transduced with a control or MMP-9-specific shRNA to deplete MMP-9 prior to induction ( FIG. 2C ). MMP-9 depletion impeded nuclear gelatinase activity in OCP-induced cells concurrent with the significant and sustained impairment of H3NT proteolysis ( FIGS. 2B and 2D ). The continuous impairment of H3NT cleavage was similarly observed in OCP-induced cells treated with a selective MMP-9 inhibitor ( FIG. 2D ). These collective results support the dependence of H3NT proteolysis on nuclear MMP-9 activity during osteoclastogenesis. 
     H3K18 is the Primary P1 Site of MMP-9 
     Previous reports demonstrated that H3A21 is the primary cleavage site (P1) for cysteine and serine proteases, however, the H3NT P1 site of the MMP-9 metalloproteinase was unknown (Duncan et al. 2008; Santos-Rosa et al. 2009). In silico analysis of histone H3 identified K18 as the only potential P1 site on the H3NT, which was also predicted to be cleaved by MMP-9 ( FIG. 10A ) (Song et al. 2012). To test these predictions, LC-MS/MS of the gel-excised rH3-cleaved product generated by rMMP-9 was performed ( FIG. 3A ). Peptide fragments containing H3 residues prior to Q19 were not identified in the proteomic analysis, supporting H3K18 as the major P1 site of MMP-9. This result suggested that the sequence flanking H3K18 is a putative MMP-9 consensus site. To test this in vitro, rH3 containing mutated residues predicted necessary for MMP-9 activity were used as substrates in the H3NT cleavage assay ( FIG. 3B  and  FIG. 10B ). Mutation of rH3 at (P1, K18R; Pa′, Q19G) or flanking (P3, P16G; P3′, A21F) the cleavage site ablated H3NT proteolysis by rMMP-9, confirming that the H3 aa16-21 sequence is an MMP-9 consensus site in vitro ( FIG. 3C ). These results suggested that similar H3 mutations would ablate H3NT proteolysis during osteoclastogenesis. To test this, C-terminal FLAG-tag fusions of wild type H3 or the H3 mutants were transduced in OCP cells prior to induction. Western blot analysis of chromatin extracts confirmed proteolysis of wild type H3-FLAG in OCP-induced cells ( FIG. 3D ). Although mutant H3-FLAG proteins were also readily detected in chromatin extracts, each mutation of the MMP-9 consensus sequence abrogated H3NT proteolysis in OCP-induced cells. These findings support MMP-9 as the primary protease that directly cleaves H3K18-Q19 during osteoclastogeneis. 
     Acetylation of H3K18 Augments MMP-9 Activity 
     Analysis of the canonical MMP-9 consensus sequence indicated that MMP-9 preferentially cleaves uncharged residues over charged residues at the P1 site ( FIG. 10B ). Based on this, Applicants hypothesized that neutralizing the H3K18 charge by acetylation would augment MMP-9 activity. As predicted, kinetic analysis of MMP-9 activity using H3 peptide substrates confirmed that K18ac selectively amplified rMMP-9 activity resulting in a 3-fold increase of cleaved H3 compared to unmodified H3 or H3K27mea peptides ( FIG. 4A ). Consistent with these results, H3NT cleavage assays using rH3 acetyl-lysine analogues as substrates demonstrated that the specific acetylation of K18 robustly increased H3NT proteolysis by rMMP-9 ( FIG. 4B ) (Shogren-Knaak and Peterson 2004). MMP-9 activity with rH3 methyl-lysine analogues at K4, K9, K27 or K36 was nearly identical to rH3 control in all cases ( FIG. 11A ). These findings suggested that the acetylation of H3K18 facilitates MMP-9 activity in chromatin. To test this, nucleosome arrays containing unmodified rH3, the rH3 acetyl-lysine analogues or modified native histones purified from HeLa cells were generated in vitro and used as substrates in the H3NT cleavage assay (Kim et al. 2013a). Remarkably, unmodified nucleosome array substrates were completely resistant to rMMP-9 protease activity, in contrast to unmodified rH3 and octamer substrates ( FIGS. 4B-4C  and  FIG. 8 ). Conversely, rMMP-9 displayed robust activity for modified native nucleosome arrays supporting the dependence of MMP-9 H3NT protease activity on specific histone PTMs in chromatin ( FIG. 4C ). Consistent with this, H3NT cleavage assays confirmed that the specific acetylation of H3K18 was both necessary and sufficient for H3NT cleavage by rMMP-9 in a nucleosome array context ( FIG. 4B ). These results suggested that acetylation of H3K18 was required for MMP-9-dependent H3NT cleavage during osteoclastogenesis. To test this, OCP cells were transduced with a control shRNA or an shRNA to deplete the CBP/p300 acetyltransferases, which are responsible for the majority of H3K18ac, prior to induction (Henry et al. 2013). Diminishment of H3K18ac in CBP/p300 depleted OCP-induced cells resulted in the sustained impairment of H3NT proteolysis without perturbing the nuclear abundance of active MMP-9 ( FIGS. 4D-4E ). Identical results were obtained from OCP-induced cells treated with a selective CBP/p300 inhibitor ( FIG. 4E ). Depletion of the known H3K18 acetyltransferases GCN5, Tip60 or MOZ did not impair H3NT proteolysis during osteoclastogenesis, in contrast to CBP/p300 depletion ( FIGS. 11B-11C ). These collective results support the regulation of MMP-9-dependent H3NT cleavage during osteoclastogenesis by the CBP/p300-mediated acetylation of H3K18. 
     MMP-9 is Required for Osteoclastogenic Gene Activation and Proficient Osteoclastogenesis 
     It was previously reported that H3NT cleavage facilitates gene activation in yeast during sporulation, suggesting that MMP-9-dependent H3NT proteolysis similarly functions in gene activation during osteoclastogenesis (Santos-Rosa et al. 2009). To test this, Applicants sought to identify the genes regulated by MMP-9 using RNA-Seq of total mRNA isolated from control or MMP-9 depleted 3-day OCP-induced cells ( FIG. 2C ). Comparative transcriptome analysis revealed 1,131 differentially expressed genes between the samples (Table 1 and  FIGS. 12A-12B ). Table 1 discloses “DEAH” as SEQ ID NO: 23 and “DEAD” as SEQ ID NO: 24). More than 67% of these genes displayed significantly reduced expression in MMP-9 depleted cells, supporting a function for MMP-9 in gene activation during osteoclastogenesis ( FIG. 5A ). Gene ontology analysis revealed that many of these genes are regulatory components of osteoclastogenic signaling pathways including the RANKL, AMPK and VEGF pathways ( FIG. 12C ). In addition, gene set enrichment analysis (GSEA) demonstrated that the expression of a large set of RANKL and bone remodeling pathway genes was significantly reduced in MMP-9 depleted cells compared to control cells ( FIG. 5B ). Examination of the leading-edge subset of these genes identified 26 canonical osteoclastogenic genes that required MMP-9 for their activation, including Nfatc1, Lifand Xpr1 ( FIG. 5C ) (Takayanagi et al. 2002; Bozec et al. 2008; Sharma et al. 2010). Importantly, the diminished H3NT cleavage and defective osteoclastogenic gene activation observed in MMP-9 depleted or inhibited 5-day OCP-induced cells were concurrent with a significant reduction of mature osteoclasts compared to control cells ( FIG. 5D  and  FIG. 12D ). Similar results obtained from CBP/p300 depleted or inhibited 5-day OCP-induced cells further support the dependence of osteoclastogenic gene activation and proficient osteoclast differentiation on H3NT proteolysis ( FIG. 5D  and  FIG. 12D ). 
     ChIPac-Seq: A Novel Approach to Identify H3NT-Cleaved Regions 
     The results suggested that MMP-9-dependent H3NT proteolysis directly regulates gene expression during osteoclastogenesis but the possible indirect effects of MMP-9 depletion on gene expression, independent of H3NT cleavage, could not be distinguished by transcriptomic analysis. Therefore, Applicants sought to determine the genomic sites targeted for H3NT proteolysis during osteoclastogenesis to directly investigate the role of H3NT cleavage in transcriptional regulation, however, a method to identify H3NT-cleaved sites in mammalian cells has not been reported. Applicants hypothesized that mapping these sites could be achieved by comparative ChIP-Seq analysis of the H3NT between control and MMP-9 depleted 3-day OCP-induced cells that exhibit or lack H3NT cleavage, respectively ( FIG. 2D ). Computational identification of genomic regions displaying significantly reduced H3NT enrichment in control versus MMP-9 depleted cells would indicate those regions selectively targeted for H3NT proteolysis during osteoclastogenesis. This ChIP approach requires an antibody that has specific affinity for the H3NT of all H3 proteins, is not dependent on or inhibited by existing H3 PTMs and is validated for ChIP applications, however, such an antibody is currently unavailable to the best of Applicants&#39; knowledge. To bypass this technical barrier, established biochemical techniques were utilized to develop a novel method, called ChIP of acetylated chromatin (ChIPac), for identification and examination of H3NT-cleaved regions ( FIG. 6A ). Applicants reasoned that an H3K14 acetyl-specific antibody satisfies the criteria above for ChIP of the H3NT following complete lysine acetylation of crosslinked chromatin in vitro by acetic anhydride. First, cells were fixed with methylene blue to crosslink chromatin after brief exposure to white light (Tuite and Kelly 1993). Because formaldehyde reacts with lysine e-amino side-chains, which likely precludes complete lysine acetylation by acetic anhydride, methylene blue was used as an alternative for cell fixation (Metz et al. 2004). Chromatin was isolated and the efficiency of crosslinking was confirmed by SDS-CIA prior to sonication ( FIG. 13A ) (Lalwani et al. 1990). Fragmented chromatin was then treated with acetic anhydride to completely acetylate all unmodified lysine residues in vitro ( FIG. 13B ) (Nakayasu et al. 2014). ChIPac using an H3K14 acetyl-specific antibody selectively enriched H3NT-containing chromatin and simultaneously excluded chromatin lacking the H3NT. ChIPac using an H3CT antibody was performed in parallel as the normalization control. H3NT-cleaved regions were identified by the significant reduction in H3K14ac enrichment relative to control as determined by qPCR or NextGen sequencing analysis. 
     Specific Gene TSSs are Targeted for H3NT Proteolysis During Osteoclastogenesis 
     ChIPac-Seq was performed using control and MMP-9 depleted 3-day OCP-induced cells to identify the specific sites targeted for H3NT proteolysis during osteoclastogenesis. MMP-9 depleted cells that lack H3NT-cleaved chromatin displayed nearly indistinguishable enrichment patterns between H3K14ac and H3CT control, as predicted ( FIG. 6B  and FIGS.  13 C- 13 D). These important results validated the ChIPac approach to purify all H3NT-containing chromatin using the H3K14ac-specific antibody. The capability of ChlPac-Seq to identify specific H3NT-cleaved regions was confirmed in control 3-day OCP-induced cells, which resulted in the identification of 1,233 regions displaying significantly reduced H3K14ac enrichment relative to MMP-9 depleted cells. The maximal peak of H3K14ac depletion within each H3NT-cleaved region and the gene nearest this peak were determined (Table 2) (Kim et al. 2013b). Applicant&#39;s subsequent computational analyses focused on the +/−4 kb region near gene transcription start sites (TSSs) since H3NT cleavage was previously reported at gene promoters in yeast (Santos-Rosa et al. 2009). K means clustering of TSSs revealed that &lt;8% of all protein coding genes exhibited H3K14ac depletion near TSS indicating that these sites are selectively targeted for H3NT proteolysis during osteoclastogenesis ( FIG. 6B  and  FIGS. 13C-13D ). Strikingly, these genes partitioned into three distinct groups based on the location of H3NT cleavage: promoter-specific (P, 31%), coding region-specific (CR, 42%) or both (P+CR, 27%). Profiling the average tag densities in each group showed that H3NT cleavage typically peaks ˜2 kb from TSS ( FIG. 6C ). Gene pathway analysis indicated that H3NT-cleaved genes are significantly linked to the RANKL and bone remodeling pathways ( FIG. 13E ). Several canonical osteoclastogenic genes were identified within each H3NT-cleaved group, including Nfatc1 (P), Lif (CR) and Xpr1 (P+CR). Notably, MMP-9 was required for H3NT cleavage near Nfatc1, Lif and Xpra TSSs and their concurrent activation during osteoclastogenesis, suggesting that H3NT proteolysis facilitates gene activation ( FIG. 13C ). 
     H3NT Cleavage Correlates with Gene Activation 
     To broadly examine the association between H3NT cleavage and gene expression, the RNA-Seq data was analyzed for the 1,233 H3NT-cleaved genes identified in control and MMP-9 depleted 3-day OCP-induced cells. Comparative analyses revealed that most H3NT-cleaved genes (&gt;53%) displayed significant expression differences in control versus MMP-9 depleted cells ( FIG. 7A ). The majority of these genes (&gt;82%), including Nfatc1, Lif and Xpr1, exhibited significantly reduced expression in MMP-9 depleted cells indicating a strong functional correlation between MMP-9 and gene activation ( FIG. 7A ). To further investigate the MMP-9-dependent activation of these genes during osteoclastogenesis, RT-qPCR was performed in OCP cells transduced with a control or MMP-9-specific shRNA, or treated with DMSO control or a selective MMP-9 inhibitor, and cultured with or without RANKL for 3 days. Ablation of H3NT cleavage in MMP-9 depleted or inhibited 3-day OCP-induced cells significantly impaired Nfatc1, Lif and Xpr1 activation, suggesting that H3NT proteolysis directly facilitates their activation during osteoclastogenesis ( FIGS. 2D, 7B  and  FIG. 14 ). Applicants reasoned that repeating these experiments in CBP/p300 depleted or inhibited 3-day OCP cells would test this hypothesis, as non-acetylated H3K18 impedes MMP-9 H3NT protease activity ( FIG. 4 ). Consistent with the hypothesis, diminishment of H3K18 acetylation by CBP/p300 depletion or inhibition ablated H3NT cleavage and significantly impaired Nfatc1, Lif and Xpr1 activation, identical to the effects of MMP-9 depletion, but without altering nuclear abundance of the active MMP-9 enzyme ( FIGS. 4D-4E, 7B  and  FIG. 14 ). These results further support the direct function of H3NT cleavage in gene activation and suggest that CBP/p300-mediated acetylation of H3K18 is a key regulator of MMP-9 H3NT protease activity during osteoclastogenesis. 
     The Sites and Extent of H3NT Proteolysis are Directly Linked to H3K18 Acetylation 
     Identification of the specific H3NT-cleaved sites at Nfatc1 (P), Lif (CR) and Xpra (P+CR) allowed us to directly examine the necessity of H3K18 acetylation on MMP-9 H3NT protease activity and gene activation during osteoclastogenesis. OCP cells were transduced with a control, MMP-9-specific or CBP/p300-specific shRNA, cultured with or without RANKL for 3 days and then processed for ChIPac or conventional ChIP using an H3K18ac-specific antibody. Subsequent qPCR confirmed the site-specific H3NT cleavage at Nfatca (P), Lif (CR) and Xpra (P+CR) in induced versus non-induced control shRNA cells ( FIG. 7C ). In contrast, H3K18ac enrichment at all sites examined were remarkably similar between induced and non-induced control shRNA cells ( FIG. 7D ). These results and the findings above suggested that H3NT cleavage sites are selectively targeted for H3K18 acetylation to activate MMP-9 H3K18-Q19 proteolysis, resulting in a tailless H3 that is exempt from enrichment by the H3K18ac ChIP. Consistent with this model, significantly increased H3K18ac enrichment at each H3NT cleavage site, but not the flanking non-cleavage sites, was concurrent with the ablation of H3NT cleavage at these sites in MMP-9 depleted 3-day OCP-induced cells ( FIGS. 7C-7D ). Notably, the relative increase of H3K18ac at each H3NT cleavage site observed in MMP-9 depleted cells was directly proportional to the relative decrease of H3K14ac observed in control shRNA cells, suggesting that H3K18 acetylation directly regulates the sites and extent of MMP-9 H3NT protease activity during osteoclastogenesis. Consistent with this, preclusion of H3K18 acetylation at each H3NT cleavage site was concurrent with the loss of H3NT cleavage at these sites in CBP/p300 depleted 3-day OCP-induced cells, despite the presence of active MMP-9 in the nucleus ( FIGS. 4D and 7C-7D ). The collective results indicate that the targeted CBP/p300-dependent acetylation of H3K18 at Nfatc1 (P), Lif (CR) and Xpr1 (P+CR) is prerequisite but insufficient for their expression, thereby, further supporting the necessity of H3NT proteolysis for their activation during osteoclastogenesis. 
     Cell Transduction and Inhibition 
     Retroviral particles were generated in Plat-E cells transfected with pMX-H3-Flag (Cell Biolabs) according to the manufacturers&#39; instructions. Lentiviral particles were generated in HEK-293T cells by co-transfecting plasmids encoding VSV-G, NL-BH and pLKO.1-shRNA (Addgene) for MMP-9 (5′-GAGGCATACTTGTACCGCTAT (SEQ. ID NO: 19), p300 (5′-CCCTGGATTAAGTTTGATAAA (SEQ ID NO: 20)) or CBP (5′-TAACTCTGGCCATAGCTTAAT (SEQ ID NO: 21)). OCP cells were transduced and selected with puromycin (2 μg/ml) or cultured with DMSO, 10 nM MMP-9-INI (Santa Cruz) or 1.6 μM C646 (ApexBio) for 3 days prior to differentiation. 
     Chromatin Extraction and Western Blot Analysis 
     Chromatin was extracted by first resuspending cells in buffer A (10 mM HEPES, pH 7.4, 10 mM KCl, 1.5 mM MgCl2, 0.34 M sucrose, 10% glycerol, 1 mM DTT, 5 mM β-glycerophosphate, 10 mM NaF, protease inhibitors, and 0.2% Triton X-100) and incubating on ice for 8 min. Nuclei were isolated by centrifugation (1,300 g for 10′ at 4° C.), resuspended in buffer B (3 mM EDTA, 0.2 mM EGTA, 1 mM DTT, 5 mM 3-glycerophosphate, 10 mM NaF, and protease inhibitors), centrifuged (1,700 g for 5 min at 4° C.) and the chromatin pellet was washed three times with buffer B prior to sonication in Laemmli buffer. Western blot analysis was performed using antibodies specific for H2A, H2B, H3 and H4 (Abcam); H3K9ac, H3K14ac, H3K18ac and H3K23ac (Active Motif); MMP-9, p300 (Santa Cruz) and CBP (BioLegend); His (Novagen) and FLAG (Sigma). 
     Recombinant Proteins and H3 Cleavage Assays 
     His-tagged proteins were generated in Rosetta 2 (DE3) pLysS  E. coli  (Novagen) and purified as previously described (Kim et al. 2008). MMP-9 (aa1115-730) was purified from inclusion bodies dissolved with lysis buffer (6 M urea, 0.5 M NaCl, 5 mM imidazole, 20 mM Tris, pH 7.9), refolded in 50 mM HEPES, 0.2 M NaCl, 1M NDSB201 (Sigma) and dialyzed in 50 mM Tris, pH 7.5, 0.1 M NaCl, 5 mM CaCl 2 ), 20 uM ZnCl2 and 30% glycerol. Recombinant and native histone octamers and nucleosome arrays were prepared as previously described (Kim et al. 2012). Cell extracts or recombinant proteins were incubated with histone octamer (1 rg) or nucleosomes (2 μg) in cleavage buffer (20 mM HEPES-KOH, pH 7.8, 1 mM CaCl 2 ), 20 mM KCl) for 0.5-2 hours at 37° C.+/−protease inhibitors aprotinin (10 μg/ml), bestatin (130 μm), EDTA (25 mM), leupeptin (100 μM), pepstatin A (1.5 M), PMSF (1 mM) or L006235 (20 nM). H3 tail peptides (aa10-35) were synthesized by solid-phase Fmoc/tBu chemistry and purity confirmed by ES-MS (EZBiolab). Peptides were incubated with rMMP-9 at seven different concentrations (0, 25, 50, 100, 150, 200, and 250 jM) in cleavage buffer, the reactions stopped by adding 20 mM o-phenanthroline (Sigma) and peptide hydrolysis was measured by adding 5 mM fluorescamine followed by detection at λ ex  365 nm and λ em  450 nm using a Plate Chameleon spectrofluorometer (Hidex). Kinetic parameters were determined by Michaelis-Menten analysis. 
     Chromatography 
     Nuclear extracts were fractionated on a P11 column (Pharmacia) equilibrated with BC100 buffer (20 mM HEPES-KOH, pH 7.9, 0.5 mM EDTA, 0.05% Nonidet P-40, 10% glycerol, 1 mM DTT, 100 mM KCl) as previously described (Kim et al. 2013b). H3NT active fractions were combined and dialyzed against Buffer R (10 mM HEPES-NaOH, pH7.6, 10 mM KCl, 1.5 mM MgCl2, 10% glycerol, 10 mM β-glycerophosphate, 1 mM DTT), loaded onto a Q-Sepharose column (Phamacia) and eluted with stepwise increased salt concentration in BR buffer. H3NT active fractions were combined and applied to a 5-ml 15-40% glycerol gradient in BR200 buffer containing 0.1% Nonidet P-40, centrifuged in an SW 55Ti rotor (150,000 g for 20 hours at 4° C.) and fractions (150 μl) were collected from the top of the tube. H3NT active fractions (#3-5) were combined for protein identification by LC-MS/MS analysis. 
     RNA-Seq 
     RNA Isolation and Library Preparation. 
     RNA was prepared using the Qiagen RNeasy kit (Qiagen, Valencia, Calif.) according to the manufacturer&#39;s instructions. For quality control, RNA purity and integrity were verified by denaturing gel electrophoresis, OD 260/280 ratio, and analysis on an Agilent 2100 Bioanalyzer (Agilent Technologies, Santa Clara, Calif.). Strand specific library perpetration was carried out using a KAPA Stranded mRNA-Seq Kit, with KAPA mRNA Capture Beads (KAPA Biosystem Wilmington, Mass.). Briefly, 30 ng of total RNA was reverse transcribed to cDNA using a T7 oligo(dT) primer. Second-strand cDNA was synthesized, in vitro transcribed, and labeled via incorporation of biotin-16-UTP. Validation of the library preparations was performed on an Agilent Bioanalyzer using the DNA1000 kit. Libraries were quantified using a Roche LightCycler96 with FastStart Essential DNA Green Master mix. Library concentrations were adjusted to 4 nM and pooled for multiplex sequencing. Pooled libraries were denatured and diluted to 15 pM and then clonally clustered onto the sequencing flow cell using the Illumina cBOT Cluster Generation Station and Cluster Kit v3-cBot-HS. The clustered flow cell was sequenced with 1×50 SE reads on the Illumina HiSeq2000 according to manufacturer&#39;s protocol. Base conversion was made using OLB version 1.9, de-multiplexed and converted to Fastq using CASAVA version 1.8 (Illumina). This resulted in approximately 50 million reads for control and MMP-9 shRNA expressing OCP cells. The library preparation and sequencing were performed in conjunction with the Sequencing Core Facility of UCLA, Los Angeles. 
     Bioinformatic Analyses of RNA-Seq. 
     To check the general quality of raw sequencing reads, Applicants used in-house RNA-seq workflow (University of Southern California, Epigenome Center) which consists of several open source tools. Briefly, to check the quality of sequencing reads in FastQC, reads were trimmed on both ends based on quality score (&gt;38) of each sequence by using FASTX-Toolkit (http://hannonlab.cshl.edu). Adaptor sequences were also removed. High quality reads were aligned to the mm9 genome using TopHat-2 which uses Bowtie 2 at different steps, allowing one mismatch (in conjunction with gene model from Ensembl release 61) (Kim et al. 2013a). Potential PCR duplicated reads identified with the MarkDuplictaes using Picard (https://github.com) were excluded. Further alignment quality was checked using SamStat (Lassmann et al. 2011), RNA-seQC (DeLuca et al. 2012), Seqmonk, IGV and Qualimap (Garcia-Alcalde et al. 2012). A total of approximately 21 million unique mapped reads for each control and MMP-9 shRNA expressing OCP cells were obtained. 
     Transcript coverage. Applicants used coverage over the transcript plots to identify any problems associated with library preparation, sequencing process and distribution of reads across the genome or any bias in 5′ or 3′ expression using Qualimap and RNA-seQC packages. The majority of the reads (&gt;80%) of all samples were within exonic regions and very low number of reads mapped to intronic or intergenic regions ( FIG. 12A ). To investigate any 5′ or 3′ bias in the expression, intronic positions were removed, coverage vectors for minus-strand genes were reversed, and remaining values divided into 100 non-overlapping bins were averaged to produce a uniform 100-column matrix of gene coverage for each sample. Genes &lt;100 bp were not included in the analysis. Gene-wise trends in coverage bias and variability were studied by taking the coefficient of variance of the original coverage vector per gene and that of the ratio of the first-quarter mean depth (5′ coverage) to fourth-quarter mean depth (3′ coverage) on the gene body. Global coverage bias per sample was plotted against normalized coverage ( FIG. 12B ) as detailed previously (Graw et al. 2015). To obtain an overall robust gene expression, Applicants used an exon model by counting all reads mapped to only exons and combining all exons to a gene so that Applicants have read count per gene (RPKM) (Mortazavi et al. 2008). The RPKM values were adjusted globally by matching count distributions at the 75th percentile and then adjusting counts to a uniform distribution between samples. Finally differential expression was estimated by selecting transcripts that displayed significant changes (p&lt;0.05) after Benjamini and Hochberg correction using a null model constructed from 1% of transcripts showing the closet average level of observation to estimate experimental noise (Ring et al. 2015). The gene list was further ranked using fold change criteria. GSEA and leading edge analyses were performed on the ranked list using gene sets from the C2 collection of the GSEA Molecular Signatures Database v3.0 and several gene sets associated with bone remodeling as detailed previously (Kim et al. 2015). 
     ChIPac-Seq 
     ChIP-ac. 
     Cells were fixed with 10 μM methylene blue (Sigma) on ice and exposed to white light from a 100 W incandescent bulb at a distance of 3 cm for 3′. Crosslinking was confirmed by SDS-chloroform-isoamyl alcohol (SDS-CIA) of extracted chromatin prior to dialyzation against acetylation buffer (50 mM NaHCO 3 , pH 8.0, 150 mM NaCl, 0.01% SDS). Chromatin was acetylated with acetic anhydride (20 mM final) in an ice-bath for 1 h while maintaining the pH at 8.0-8.2 by addition of NaOH. Acetylated chromatin was immunoprecipitated with an H3K14ac-specific antibody (Active Motif) or an H3 C-terminal (H3CT) antibody (Abcam) as previously described (Kim et al. 2015). 
     Library Preparation. 
     DNA libraries were constructed from −30 ng of DNA obtained from each ChIP sample. ChIP DNA and input DNA were first band-isolated on a 2% agarose gel to obtain fragments between 150 and 350 base pairs and DNA was extracted using the QIAquick gel extraction kit (Qiagen) and eluted in 35 μL elution buffer. For input, DNA was diluted 1:5 after gel extraction. The DNA was end-repaired and adapters were ligated to samples for 15 min at room temperature. Adapters in excess were eliminated by gel purification on a 2% agarose gel. A final size selection was performed using a 2% agarose gel to obtain a library with a median length of ˜230 bp which is within the recommended size range for cluster generation on Illumina&#39;s flow cell. Following PCR, reactions were cleaned using magnetic beads and re-suspended in a small volume of 10 mM Tris 8.5 (Qiagen EB). Libraries were visualized by Agilent Bioanalyzer and quantified using the KAPA Biosystems Library Quantification Kit, according to manufacturer&#39;s instructions. Sequencing with 1×50 SE reads was carried out on the Illumina flow cell of HiSeq 2000 as recommended by manufacturer (Illumina). Image analysis and base calling were carried out using RTA 1.13.48.0. Final file formatting, de-multiplexing and fastq generation were carried out using CASAVA v 1.8.2. 
     ChlPac-Seq Quality Assessment. 
     All ChIP and input sample qualities were monitored using established strategies (Landt et al. 2012; Bailey et al. 2013). The quality matrices for raw sequence reads were obtained by FASTQc (http://www.bioinformatics.bbsrc.ac.uk). The reads were processed by Trim Galore (http://www.bioinformatics.babraham.ac.uk). The low sequencing quality nucleotides at the 3′ end were removed, and only the reads longer than 75 bp were retained. Adaptor sequences were also removed using function cutadapt. The processed sequences were mapped to the mm9 genome using Burrows-Wheeler Aligner (Li et al. 2008). Further reads aligning to mitochondrial DNA, repetitive elements or unassigned sequences were discarded. This resulted in uniquely aligned reads from approximately 13 to 34 million reads covering the mouse genome. Applicants used deeptools (https://pypi.python.org/pypi/deepTools) to estimate distribution of ChIP signal from background noise (function-bamFingerprint) and cross-sample normalization was achieved by scaling read depths to reads using function-bamCoverage. Since the DNA polymerases, used in PCR-amplifications during the library preparation, prefer GC-rich regions and may influence the outcome of the sequencing, the GCbias was estimated in each sample but no correction was applied (data not shown). To validate the ChIPac-Seq approach, a function-bamFingerprint was used on uniquely mapped reads, which randomly samples genome regions into a specified length (10 bp bin) and counts the reads from indexed bam files that overlap with those regions. These counts were then sorted according to their rank (the bin with the highest number of reads will have the highest rank) and the cumulative sum of read counts was plotted (Diaz et al. 2012). In all cases it is possible to differentiate read density of the ChIPac sample from the input sample. 
     Establishment of Reference Loci. 
     To calculate the differential tag density of each ChIPac sample, Applicants used a binning approach (Diaz et al. 2012). Applicants normalized tag density to 1× coverage to compensate for the varying sequencing depth and mapping efficiency of each sample. Such normalization is achieved by first determining the actual read coverage (number of mapped reads*fragment length/effective genome size) and then using this number to determine the scaling factor that would yield a 1× coverage, as previously detailed (Kramer et al. 2011). Since each short read represents the end of an immunoprecipitated nucleosome, every read was extended 3′ to a total of 200 bp to cover an entire nucleosome prior to analysis. Signal density was calculated in sliding 1 kb windows and normalized aligned reads were considered to be within a window of the midpoint of its estimated fragment. Mid-points in each window were counted, and empirical distributions of window counts were created. Genomic bins containing statistically significant regions were identified by comparison to a Poisson background model assuming that background reads are spread randomly throughout the genome (Kim et al. 2013c). 
     Identification and Analyses of H3NT-Cleaved Genes. 
     Applicants extracted the tag density in a ±4 kb window surrounding the TSSs using the program ngs.plot (https://github.com) (Shen et al. 2014) and  Seqminer  (Ye et al. 2011). To identify H3NT-cleaved regions in specific genomic loci, relative signal densities were defined as read counts per bin fixed divided by the total number of aligned reads in all bins. The loci which displayed differential read count in 1 kb windows between control shRNA H3K14ac over H3CT, as well as MMP-9 shRNA samples (H3K14ac and H3CT) with log 2 ratio &gt;0.26 or absolute difference+1.2 were identified and annotated with closet gene (2000 bp in either direction). For visualization, alignment files were transformed into read coverage files (20 bp bin and smooth length 50 bp) to generate bigWig files. Seqmonk and IGV were used at different steps to visualize the data. Unless specified, command line option was used to extract data matrix and figures were generated in R (http://www.r-project.org). K-means clustering of tag densities+/−4 kb of TSSs was determined in R (http://www.r-project.org). Table 2 lists the H3NT-cleaved genes identified within each cluster. To study the functional significance of all H3NT-cleaved genes as well as the independent P, CR and P+CR clusters, Applicants quarried the Wikipathway database (Pico et al. 2008). A ranked p-value was computed from the fisher exact test based on the bionomical distribution and independence for probability of any gene belonging to any enriched set. As shown in  FIG. 13E , all three clusters as well as P and CR clusters (but not P+CR, p&gt;0.9) individually displayed a significant enrichment in RANKL and associated osteoclastogenic pathways (p&lt;0.0001). 
     PCR 
     qPCR was performed using PerfeCta® SYBR Green FastMix (Quanta BIOSCIENCES) and an iCycler IQ5 (Bio-Rad). Primers are: Nfatc1 (P: 5′-GAAGTGGTAGCCCACGTGAT (SEQ ID NO: 1), 5′-TCTTGGCACCACATAAACCA (SEQ ID NO: 2); CR: 5′-GGGTCAGTGTGACCGAAGAT (SEQ ID NO: 3), 5′-GGAAGTCAGAAGTGGGTGGA (SEQ ID NO: 4); mRNA: 5′-CTCGAAAGACAGCACTGGAGCAT (SEQ ID NO: 5), 5′-CGGCTGCCTTCCGTCTCATAG) (SEQ ID NO: 6), Lif(P: 5′-CTCTGGCTGTCCTGGAACTC (SEQ ID NO: 7), 5′-CCAGGACCAGGTGAAACACT (SEQ ID NO: 8); CR: 5′-ATCTTGTGGCTTTGCCAACT (SEQ ID NO: 9), 5′-AGTCCTTGCCTGTCTTTCCA (SEQ ID NO: 10); mRNA: 5′-AGAAGGTCCTGAACCCCACT (SEQ ID NO: 11), 5′-AGAAGGTCCTGAACCCCACT-3′ (SEQ ID NO: 12)) and Xpr1 (P: 5′-AGGACCTTCGGAAGAGCAGT (SEQ ID NO: 13), 5′-CAGCAAGCAGCTCATAACCA (SEQ ID NO: 14); CR: 5′-GGTGGGTTCCACTGAAAGAA (SEQ ID NO: 15), 5′-GGTTCCTCTGACCAAAAGCA (SEQ ID NO: 16); mRNA: 5′-AGGAGCGTGTCCAACATAGG (SEQ ID NO: 17), 5′-CCACGAGATGTTTCCAGGAT (SEQ ID NO: 18)). Specificity of amplification was determined by melting curve analysis and all samples were run in triplicate with results averaged. 
     Cell transduction, inhibition, chromatin extraction, Western blot analysis, antibodies, chromatography and PCR primers are detailed herein. 
     Cell Culture 
     Primary mouse OCP cells were derived, maintained and differentiated as previously described (An et al. 2014). Briefly, bone marrow (BM) cells were harvested by flushing femurs and tibias from 6- to 8-week-old C57BL/6 mice. Cells were cultured in a-minimum essential medium (α-MEM) supplemented with M-CSF (5 ng/ml) and 10% FBS for 16 hours. Non-adherent cells were harvested and cultured with M-CSF (30 ng/ml) for three days. Floating cells were removed. Adherent cells were used to generate osteoclasts. Adherent cells were cultured in the presence of M-CSF (30 ng/ml) and RANKL (50 ng/ml). On day 3, the cells were fixed and stained for tartrate-resistant acid phosphatase (TRAP) using a TRAP kit (Sigma). 
     Recombinant Proteins and H3 Cleavage Assays 
     His-tagged proteins were generated in Rosetta 2 (DE3) pLysS  E. coli  (Novagen) and purified as previously described (Kim et al. 2008). Recombinant and native histone octamers and nucleosome arrays were prepared as previously described (Kim et al. 2012). Cell extracts or recombinant proteins were incubated with histone octamer (1 μg) or nucleosomes (2 μg)+/−protease inhibitors and H3NT cleavage was determined by Western blot analysis. H3 peptides (aa10-35) were synthesized (EZBiolab) and incubated with rMMP-9 at increasing concentrations. Peptide hydrolysis was measured using a Plate Chameleon spectrofluorometer (Hidex) and kinetic parameters were determined by Michaelis-Menten analysis. 
     ChIPac-Seq 
     Cells were fixed with methylene blue (Sigma). Crosslinking was confirmed by SDS-chloroform-isoamyl alcohol (SDS-CIA) of extracted chromatin prior to acetylation with acetic anhydride. Acetylated chromatin was immunoprecipitated with an H3K14ac-specific antibody (Active Motif) or an H3 C-terminal (H3CT) antibody (Abcam). Libraries were constructed, sequenced and aligned to the mm9 reference genome (Li et al. 2008). Each read was extended in the sequencing orientation to a total of 200 bases to infer nucleosome coverage at each genomic position. Signal density was calculated in sliding 1 kb windows and aligned reads were considered to be within a window of the midpoint of its estimated fragment. Mid-points in each window were counted and empirical distributions of window counts were created. Genomic bins containing statistically significant regions were identified based on background distribution of randomized reads specific for each sample (Kim et al. 2013b). The ngs.plot was used to calculate the average coverage of TSSs and composite plots were generated by averaging reads in 200 bp windows (Shen et al. 2014). Peaks were annotated with non-overlapping genes from Ensembl. K-means clustering of tag densities+/−4 kb of TSSs was determined in R (http://www.r-project.org). 
     RNA-Seq 
     Libraries were generated from total RNA for sequencing. High quality reads were aligned to mm9 using TopHat in conjunction with gene model from Ensembl release 61 (Kim et al. 2013b). Data was quantitated by counting number of RPKM (Mortazavi et al. 2008). The values were adjusted globally by matching count distributions at the 15th percentile and then adjusting counts to a uniform distribution between samples. Differential expression was estimated by selecting transcripts that displayed significant changes (p&lt;0.05) after Benjamini and Hochberg correction using null model constructed from 1% of transcripts showing the closet average level of observation to estimate experimental noise. The gene list was ranked using fold change criteria. GSEA and leading edge analysis was performed on the ranked list using gene sets from the C2 collection of the GSEA Molecular Signatures Database v3.0 and several gene sets associated with bone remodeling. 
     Treating a Subject with Abnormal Bone Mineral Density 
     The levels or function of MMP-9 can be modulated to treat a subject in need thereof. A subject in need of MMP-9 modulation includes a patient with low bone mineral density (BMD) or high BMD, and/or a subject with a bone related disease or condition selected from osteoporosis, bone cancer, cancer that has metastasized to the bone, cancer-induced osteolysis, sepsis, rheumatoid arthritis, periodontitis, osteopetrosis, pycondysostosis, osteopoikilosis, meloreostosis, sclerosteosis, van Buchem&#39;s disease, LRP5 high bone mass, LRP4 high bone mass, craniometaphyseal dysplasia, Camurati-Engelmann disease, Ghosal syndrome, bone cancer, cancer metastasized to the bone, fluorosis, renal osteodystrophy, acromegaly, hepatitis C-associated osteosclerosis, myelofibrosis, mastocytosis, osseous tuberous sclerosis, Paget&#39;s disease, and SAPHO syndrome. Patients with the above-listed diseases or conditions require either activation or suppression of osteoclastogenesis. For example, in a subject with low BMD, it is desirable to inhibit osteoclastogenesis to prevent loss of bone tissue. In a subject with high BMD, it is desirable to activate osteoclastogenesis to promote bone resorbtion. 
     Measurement of BMD is well known in the art. A common BMD test is a central dual-energy x-ray absorptiometry, or central DXA test. Normal BMD values vary based on age, gender, and other environmental factors but the World Health Organization generally defines normal as within one standard deviation (SD) of the young adult mean. Low bone mass is indicated by BMD values between 1 and 2.5 SD below the young adult mean. Osteoporosis is indicated by BMD more than 2.5 SD below the young adult mean. Success of treatment can be measured by restoring the subject&#39;s BMD to normal values or improving the subject&#39;s BMD closer to normal values. 
     To suppress osteoclastogenesis, an effective amount of an agent is administered to a subject to deplete or inhibit the function of MMP-9. MMP-9 can be directly depleted and/or inhibited by administration of an effective amount of an MMP-9 inhibitor, knockdown with interfering RNA directed to MMP-9 RNA and/or knockdown with shRNA delivered by contacting the cell, tissue, or subject with an effective amount of the shRNA, transfecting the cell, tissue, or subject with a polynucleotide expression vector that encodes the shRNA, or administering an effective amount of cells expressing the shRNA such as mesenchymal stem cells. MMP-9 function may also be inhibited by treatment with a broadly reactive metalloprotease inhibitor or by inhibition of enzymes that acetylate MMP-9&#39;s target cleavage site such as CBP/p300. Once MMP-9 function is attenuated, the osteoclastogenesis pathway in the cell, tissue, or subject will not be activated. 
     To activate osteoclastogenesis, MMP-9 function is activated and/or its expression levels are increased in a cell, tissue, or subject. MMP-9 function specific to osteoclastogenesis can be increased by promoting additional import of MMP-9 to the nucleus by adding nuclear localization signals to the enzyme. MMP-9 activity in the nucleus may also be increased by increasing the levels of acetylation at the MMP-9 target site and/or by over-expression of MMP-9. Subjects with abnormally high bone mineral density can be treated by administration of an effective amount of nuclear MMP-9 and/or administration of an effective amount of genetically engineered stem cells or osteoclast precursor cells that ectopically express MMP-9. Increased MMP-9 activity will then stimulate osteoclastogenesis which results in bone resorbtion. 
     Accession Numbers 
     Sequencing data sets were deposited at NCBI GEO (GSE72846 and GSE72957). 
     The contents of the articles, patents, and patent applications, and all other documents and electronically available information mentioned or cited herein, are hereby incorporated by reference in their entirety to the same extent as if each individual publication was specifically and individually indicated to be incorporated by reference. 
     Applicants reserve the right to physically incorporate into this application any and all materials and information from any such articles, patents, patent applications, or other physical and electronic documents. 
     The disclosures illustratively described herein may suitably be practiced in the absence of any element or elements, limitation or limitations, not specifically disclosed herein. Thus, for example, the terms “comprising”, “including,” containing”, etc. shall be read expansively and without limitation. Additionally, the terms and expressions employed herein have been used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope of the claims. Thus, it should be understood that although the present disclosure has been specifically disclosed by preferred embodiments and optional features, modification and variation of the disclosures embodied therein herein disclosed may be resorted to by those skilled in the art, and that such modifications and variations are considered to be within the scope of this disclosure. 
     The disclosure has been described broadly and generically herein. Each of the narrower species and subgeneric groupings falling within the generic disclosure also form part of the disclosure. This includes the generic description of the disclosure with a proviso or negative limitation removing any subject matter from the genus, regardless of whether or not the excised material is specifically recited herein. Other embodiments are within the following claims. In addition, where features or aspects of the disclosure are described in terms of Markush groups, those skilled in the art will recognize that the disclosure is also thereby described in terms of any individual member or subgroup of members of the Markush group. 
     SEQ ID NO. 22 
     MATRIX METALLOPROTEINASE-9 PREPROPROTEIN [ HOMO SAPIENS ] 
     NCBI Reference Sequence: NP_004985.2 
     LOCUS NP_004985 707 aa linear PRI 15 Mar. 2015 
     DEFINITION matrix metalloproteinase-9 preproprotein [ Homo sapiens ]. 
     ACCESSION NP_004985 
     VERSION NP_004985.2 GI:74272287 
     DBSOURCE REFSEQ: accession NM_004994.2 
     KEYWORDS RefSeq. 
     SOURCE  Homo sapiens  (human) 
     ORGANISM  Homo sapiens  
         Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;   Catarrhini; Hominidae; Homo.
 
FEATURES Location/Qualifiers
       

     source 1..707
         /organism=“ Homo sapiens”     /db xref=“taxon:96(6”   /chromosome=“20”   /map=“20q13.12”       

     Protene 1..707
         /product=“matrix metalloproteinase-9 preproprotein”   /EC_number=“3.4.24.35”   /note=“type V collagenase; matrix metalloproteinase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase); macrophage gelatinase; matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase)”       

     sig_peptide 1..19
         /inference=“COORDINATES: ab initio prediction:SignaIP:4.0”   /calculated_mol_wt=2106       

     proprotein 20..707
         /product=“matrix metalloproteinase-9 proprotein”   /calculated_mol wt=76371       

     Site 59..60
         /site_type=“cleavage”   /experiment=“experimental evidence, no additional details recorded”   /note=“Cleavage, by MMP3; propagated from UniProtKB/Swiss-Prot (P14780.3)”       

     Region 97..104
         /region_namc=“Cysteine switch. {ECO:0000250}”   /experiment=“experimental evidence, no additional details recorded”   /note=“propagated from UniProtKB/Swiss-Prot (P14780.3)”       

     Site 106..107
         /site_type=“cleavage”   /experiment=“experimental evidence, no additional details recorded”   /note=“Cleavage, by MMP3; propagated from UniProtKB/Swiss-Prot (P14780.3)”       

     mat_peptide 107..707
         /product=“82 kDa matrix metalloproteinase-9”   /experiment=“experimental evidence, no additional details recorded”   /note=“propagated from UniProtKB/Swiss-Prot (P14780.3)”   /calculated mol wt=66610       

     Region 115..444
         /region_name=“Peptidase_M10”   /note=“Matrixin; pfam00413”   /db_xref=“CDD:249842”       

     Region 115..444
         /region_name=“ZnMc_MMP”   /note=“Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate . . . ; cd04278”   /db xref=“CDD:239805”       

     Site order(167,179,186.. 192,201,401..402,411,421..423)
         /site_type=“other”   /note=“TIMP-binding surface”   /db_xref=“CDD:239805”       

     Region 224..271 
     /region_name=“FN2” 
     /note=“Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibmnectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and . . . ; cd00062” 
     /db xref=“CDD:280′19” 
     Site order(234,236,241,255,262,268,270)
         /site_type=“other”   /note=“putative gelatin-binding site”   /db xref=“CDD:2330 19”       

     Region 282..329
         /region_name=“FN2”   /note=“Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and . . . ; cd00062”   /db xref=“CDD:2380)19”       

     Site order(292,294,299,313,320,326,328)
         /site_type=“other”   /note=“putative gelatin-binding site”   /db xref=“CDD:2.38019”       

     Region 341..388
         /region_name=“FN2”   /note=“Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and . . . ; cd00062”   /db xref=“CDD:23801 9”       

     Site order(351,353,358,372,379,385,387)
         /site_type=“other”   /note=“putative gelatin-binding site”   /db xref=“CDD:238019”       

     Site order(401..402,405,411)
         /site_type=“active”   /db xref=“CDD:239805”       

     Region 472..506
         /region_name=“PT”   /note=“PT repeat; pfam04886”   /db xref=“CDD:1 13652”       

     Region 514..704
         /region_name=“HX”   /note=“Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of . . . ; cd00094”   /db_xref=“CDD:238046”       

     Region 518..563
         /region_name=“Hemopexin 1”   /experiment=“experimental evidence, no additional details recorded”   /note=“propagated from UniProtKB/Swiss-Prot (P14780.3)”       

     Site order(522,524,568,570,614,616,662,664)
         /site_type=“metal-binding”   /note=“Metal binding sites [ion binding]”   /db xref=“CDD:2380,46”       

     Region 564..608
         /region_name=“Hemopexin 2”   /experiment=“experimental evidence, no additional details recorded”   /note=“propagated from UniProtKB/Swiss-Prot (P14780.3)”       

     Region 610..657
         /region_name=“Hemopexin 3”   /experiment=“experimental evidence, no additional details recorded”   /note=“propagated from UniProtKB/Swiss-Prot (P14780.3)”       

     Region 658..704
         /region name=“Hemopcxin 4”   /experiment=“experimental evidence, no additional details recorded”   /note=“propagated from UniProtKB/Swiss-Prot (P14780.3)”
 
CDS 1..707
       

     /gene=“MMP9” 
     /gene_synonym=“CLG4B; GELB; MANDP2; MMP-9” 
     /coded_by=“NM_004994.2:20..2143” 
     /db_xref=“CCDS:CCDS13390.1” 
     /db_xref=“GcneID:4318” 
     /db_xrcf=“HGNC:HGNC7176” 
     /db_xref=“MIM:120361” 
     
       
         
           
               
               
               
            
               
                   
                 ORIGIN 
                   
               
            
           
           
               
               
            
               
                 (SEQ ID. NO: 22) 
                   
               
            
           
           
               
               
               
            
               
                   1 
                 mslwqplvlv llvlgccfaa prqrqstlvl fpgdlrtnlt drqlaeeyly rygytrvaem 
                   
               
               
                   
               
               
                  61 
                 rgeskslgpa llllqkqlsl petgeldsat lkamrtprcg vpdlgrfqtf egdlkwhhhn 
               
               
                   
               
               
                 121 
                 itywiqnyse dlpravidda farafalwsa vtpltftrvy srdadiviqf gvaehgdgyp 
               
               
                   
               
               
                 181 
                 fdgkdgllah afppgpgiqg dahfdddelw slgkgvvvpt rfgnadgaac hfpfifegrs 
               
               
                   
               
               
                 241 
                 ysacttdgrs dglpwcstta nydtddrfgf cpserlytqd gnadgkpcqf pfifqgqsys 
               
               
                   
               
               
                 301 
                 acttdgrsdg yrwcattany drdklfgfcp tradstvmgg nsagelcvfp ftflgkeyst 
               
               
                   
               
               
                 361 
                 ctsegrgdgr lwcattsnfd sdkkwgfcpd qgyslflvaa hefghalgld hssvpealmy 
               
               
                   
               
               
                 421 
                 pmyrftegpp lhkddvngir hlygprpepe prppttttpq ptapptvcpt gpptvhpser 
               
               
                   
               
               
                 481 
                 ptagptgpps agptgpptag pstattvpls pvddacnvni fdaiaeignq lylfkdgkyw 
               
               
                   
               
               
                 541 
                 rfsegrgsrp qgpfliadkw palprkldsv feerlskklf ffsgrqvwvy tgasvlgprr 
               
               
                   
               
               
                 601 
                 ldklglgadv aqvtgalrsg rgkmllfsgr rlwrfdvkaq mvdprsasev drmfpgvpld 
               
               
                   
               
               
                 661 
                 thdvfqyrek ayfcqdrfyw rvssrselnq vdqvgyvtyd ilqcped. 
               
            
           
         
       
     
     REFERENCES 
     
         
         1. Allan J, Harborne N, Rau D C, Gould H. 1982. Participation of core histone “tails” in the stabilization of the chromatin solenoid.  The Journal of cell biology  93: 285-297. 
         2. Allis C D, Bowen J K, Abraham G N, Glover C V, Gorovsky M A. 1980. Proteolytic processing of histone H3 in chromatin: a physiologically regulated event in Tetrahymena micronuclei.  Cell  20: 55-64. 
         3. An D, Kim K, Lu W. 2014. Defective entry into mitosis 1 (Dima) negatively regulates osteoclastogenesis by inhibiting the expression of nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1).  J Biol Chem  289: 24366-24373. 
         4. Andresen K, Jimenez-Useche I, Howell S C, Yuan C, Qiu X. 2013. Solution scattering and FRET studies on nucleosomes reveal DNA unwrapping effects of H3 and H4 tail removal.  PLoS One  8: e78587. 
         5. Asp P, Blum R, Vethantham V, Parisi F, Micsinai M, Cheng J, Bowman C, Kluger Y, Dynlacht B D. 2011. Genome-wide remodeling of the epigenetic landscape during myogenic differentiation.  Proc Natl Acad Sci U.S.A  108: E149-158. 
         6. Azad G K, Tomar R S. 2014. Proteolytic clipping of histone tails: the emerging role of histone proteases in regulation of various biological processes.  Molecular biology reports  41: 2717-2730. 
         7. Bannister A J, Zegerman P, Partridge J F, Miska E A, Thomas J O, Allshire R C, Kouzarides T. 2001. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.  Nature  410: 120-124. 
         8. Black J C, Van Rechem C, Whetstine J R. 2012. Histone lysine methylation dynamics: establishment, regulation, and biological impact.  Mol Cell  48: 491-507. 
         9. Bortvin A, Winston F. 1996. Evidence that Spt6p controls chromatin structure by a direct interaction with histones.  Science  272: 1473-1476. 
         10. Bozec A, Bakiri L, Hoebertz A, Eferl R, Schilling A F, Komnenovic V, Scheuch H, Priemel M, Stewart C L, Amling M et al. 2008. Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia.  Nature  454: 221-225. 
         11. Cackowski F C, Anderson J L, Patrene K D, Choksi R J, Shapiro S D, Windle J J, Blair H C, Roodman G D. 2010. Osteoclasts are important for bone angiogenesis.  Blood  115: 140-149. 
         12. Colnot C, Thompson Z, Miclau T, Werb Z, Helms J A. 2003. Altered fracture repair in the absence of MMP9 . Development  130: 4123-4133. 
         13. Dhaenens M, Glibert P, Meert P, Vossaert L, Deforce D. 2015. Histone proteolysis: a proposal for categorization into ‘clipping’ and ‘degradation’.  BioEssays: news and reviews in molecular, cellular and developmental biology  37: 70-79. 
         14. Duarte L F, Young A R, Wang Z, Wu H A, Panda T, Kou Y, Kapoor A, Hasson D, Mills N R, Ma&#39;ayan A et al. 2014. Histone H3.3 and its proteolytically processed form drive a cellular senescence programme.  Nature communications  5: 5210. 
         15. Duncan E M, Muratore-Schroeder T L, Cook R G, Garcia B A, Shabanowitz J, Hunt D F, Allis C D. 2008. Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation.  Cell  135: 284-294. 
         16. Franco G C, Kajiya M, Nakanishi T, Ohta K, Rosalen P L, Groppo F C, Ernst C W, Boyesen J L, Bartlett J D, Stashenko P et al. 2011. Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo.  Experimental cell research  317: 1454-1464. 
         17. Henry R A, Kuo Y M, Andrews A J. 2013. Differences in specificity and selectivity between CBP and p300 acetylation of histone H3 and H3/H4 . Biochemistry  52: 5746-5759. 
         18. Khalkhali-Ellis Z, Goossens W, Margaryan N V, Hendrix M J. 2014. Cleavage of Histone 3 by Cathepsin D in the involuting mammary gland.  PLoS One  9: e103230. 
         19. Kim K, Choi J, Heo K, Kim H, Levens D, Kohno K, Johnson E M, Brock H W, An W. 2008. Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription.  J Biol Chem  283: 9113-9126. 
         20. Kim K, Heo K, Choi J, Jackson S, Kim H, Xiong Y, An W. 2012. Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail.  Mol Cell Biol  32: 783-796. 
         21. Kim K, Kim J M, Kim J S, Choi J, Lee Y S, Neamati N, Song J S, Heo K, An W. 2013a. VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription.  Mol Cell  52: 459-467. 
         22. Kim K, Punj V, Choi J, Heo K, Kim J M, Laird P W, An W. 2013b. Gene dysregulation by histone variant H2A.Z in bladder cancer.  Epigenetics  &amp;  chromatin  6: 34. 
         23. Lalwani R, Maiti S, Mukherji S. 1990. Visible light induced DNA-protein crosslinking in DNA-histone complex and sarcoma-180 chromatin in the presence of methylene blue. Journal of photochemistry and photobiology B,  Biology  7: 57-73. 
         24. Li H, Ruan J, Durbin R. 2008. Mapping short DNA sequencing reads and calling variants using mapping quality scores.  Genome research  18: 1851-1858. 
         25. Luger K, Dechassa M L, Tremethick D J. 2012. New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?  Nature reviews Molecular cell biology  13: 436-447. 
         26. Mannello F, Medda V. 2012. Nuclear localization of matrix metalloproteinases.  Progress in histochemistry and cytochemistry  47: 27-58. 
         27. Metz B, Kersten G F, Hoogerhout P, Brugghe H F, Timmermans H A, de Jong A, Meiring H, ten Hove J, Hennink W E, Crommelin D J et al. 2004. Identification of formaldehyde-induced modifications in proteins: reactions with model peptides.  J Biol Chem  279: 6235-6243. 
         28. Mortazavi A, Williams B A, McCue K, Schaeffer L, Wold B. 2008. Mapping and quantifying mammalian transcriptomes by RNA-Seq.  Nat Methods  5: 621-628. 
         29. Nagase H, Visse R, Murphy G. 2006. Structure and function of matrix metalloproteinases and TIMPs.  Cardiovascular research  69: 562-573. 
         30. Nakayasu E S, Wu S, Sydor M A, Shukla A K, Weitz K K, Moore R J, Hixson K K, Kim J S, Petyuk V A, Monroe M E et al. 2014. A method to determine lysine acetylation stoichiometries.  International journal ofproteomics  2014: 730725. 
         31. Narlikar G J, Sundaramoorthy R, Owen-Hughes T. 2013. Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes.  Cell  154: 490-503. 
         32. Nurse N P, Jimenez-Useche I, Smith I T, Yuan C. 2013. Clipping of flexible tails of histones H3 and H4 affects the structure and dynamics of the nucleosome.  Biophysical journal  104: 1081-1088. 
         33. Park-Min K H, Lim E, Lee M J, Park S H, Giannopoulou E, Yarilina A, van der Meulen M, Zhao B, Smithers N, Witherington J et al. 2014. Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation.  Nature communications  5: 5418. 
         34. Pauli A, van Bemmel J G, Oliveira R A, Itoh T, Shirahige K, van Steensel B, Nasmyth K. 2010. A direct role for cohesin in gene regulation and ecdysone response in  Drosophila  salivary glands.  Curr Biol  20: 1787-1798. 
         35. Phillips D M, Johns E W. 1959. A study of the proteinase content and the chromatography of thymus histones.  The Biochemical journal  72: 538-544. 
         36. Polak P, Karlic R, Koren A, Thurman R, Sandstrom R, Lawrence M S, Reynolds A, Rynes E, Vlahovicek K, Stamatoyannopoulos J A et al. 2015. Cell-of-origin chromatin organization shapes the mutational landscape of cancer.  Nature  518: 360-364. 
         37. Roadmap Epigenomics C, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J et al. 2015. Integrative analysis of 111 reference human epigenomes.  Nature  518: 317-330. 
         38. Santos-Rosa H, Kirmizis A, Nelson C, Bartke T, Saksouk N, Cote J, Kouzarides T. 2009. Histone H3 tail clipping regulates gene expression.  Nature structural  &amp;  molecular biology  16: 17-22. 
         39. Seto E, Yoshida M. 2014. Erasers of histone acetylation: the histone deacetylase enzymes.  Cold Spring Harbor perspectives in biology  6: a018713. 
         40. Sharma P, Patntirapong S, Hann S, Hauschka P V. 2010. RANKL-RANK signaling regulates expression of xenotropic and polytropic virus receptor (XPR1) in osteoclasts.  Biochemical and biophysical research communications  399: 129-132. 
         41. Shen L, Shao N, Liu X, Nestler E. 2014. ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases.  BMC genomics  15: 284. 
         42. Shogren-Knaak M, Ishii H, Sun J M, Pazin M J, Davie J R, Peterson C L. 2006. Histone H4-K16 acetylation controls chromatin structure and protein interactions.  Science  311: 844-847. 
         43. Shogren-Knaak M A, Peterson C L. 2004. Creating designer histones by native chemical ligation.  Methods in enzymology  375: 62-76. 
         44. Song J, Tan H, Perry A J, Akutsu T, Webb G I, Whisstock J C, Pike R N. 2012. PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites.  PLoS One  7: e50300. 
         45. Strahl B D, Allis C D. 2000. The language of covalent histone modifications.  Nature  403: 41-45. 
         46. Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J et al. 2002. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.  Developmental cell  3: 889-901. 
         47. Tuite E M, Kelly J M. 1993. Photochemical interactions of methylene blue and analogues with DNA and other biological substrates. Journal of photochemistry and photobiology B,  Biology  21: 103-124. 
         48. Vossaert L, Meert P, Scheerlinck E, Glibert P, Van Roy N, Heindryckx B, De Sutter P, Dhaenens M, Deforce D. 2014. Identification of histone H3 clipping activity in human embryonic stem cells.  Stem cell research  13: 123-134. 
         49. Vu T H, Shipley J M, Bergers G, Berger J E, Helms J A, Hanahan D, Shapiro S D, Senior R M, Werb Z. 1998. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes.  Cell  93: 411-422. 
         50. Xue Y, Vashisht A A, Tan Y, Su T, Wohlschlegel J A. 2014. PRB1 is required for clipping of the histone H3 N terminal tail in  Saccharomyces cerevisiae. PLoS One  9: e90496. 
         51. Zentner G E, Henikoff S. 2013. Regulation of nucleosome dynamics by histone modifications.  Nature structural  &amp;  molecular biology  20: 259-266. 
         52. Bailey T, Krajewski P, Ladunga I, Lefebvre C, Li Q, Liu T, Madrigal P, Taslim C, Zhang J. 2013. Practical guidelines for the comprehensive analysis of ChIP-seq data.  PLoS computational biology  9: e1003326. 
         53. DeLuca D S, Levin J Z, Sivachenko A, Fennell T, Nazaire M D, Williams C, Reich M, Winckler W, Getz G. 2012. RNA-SeQC: RNA-seq metrics for quality control and process optimization.  Bioinformatics  28: 1530-1532. 
         54. Diaz A, Park K, Lim D A, Song J S. 2012. Normalization, bias correction, and peak calling for ChIP-seq.  Statistical applications in genetics and molecular biology  11: Article 9. 
         55. Garcia-Alcalde F, Okonechnikov K, Carbonell J, Cruz L M, Gotz S, Tarazona S, Dopazo J, Meyer T F, Conesa A. 2012. Qualimap: evaluating next-generation sequencing alignment data.  Bioinformatics  28: 2678-2679. 
         56. Graw S, Meier R, Minn K, Bloomer C, Godwin A K, Fridley B, Vlad A, Beyerlein P, Chien J. 2015. Robust gene expression and mutation analyses of RNA-sequencing of formalin-fixed diagnostic tumor samples.  Scientific reports  5: 12335. 
         57. Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg S L. 2013a. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome biology 14: R36. 
         58. Kim J M, Kim K, Schmidt T, Punj V, Tucker H, Rice J C, Ulmer T S, An W. 2015. Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells.  Nucleic acids research  43: 8868-8883. 
         59. Kim K, Choi J, Heo K, Kim H, Levens D, Kohno K, Johnson E M, Brock H W, An W. 2008. Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription.  J Biol Chem  283: 9113-9126. 
         60. Kim K, Heo K, Choi J, Jackson S, Kim H, Xiong Y, An W. 2012. Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail.  Mol Cell Biol  32: 783-796. 
         61. Kim K, Lee B, Kim J, Choi J, Kim J M, Xiong Y, Roeder R G, An W. 2013b. Linker Histone H1.2 cooperates with Cul4A and PAF1 to drive H4K31 ubiquitylation-mediated transactivation.  Cell reports  5: 1690-1703. 
         62. Kim K, Punj V, Choi J, Heo K, Kim J M, Laird P W, An W. 2013c. Gene dysregulation by histone variant H2A.Z in bladder cancer.  Epigenetics  &amp;  chromatin  6: 34. 
         63. Kramer J M, Kochinke K, Oortveld M A, Marks H, Kramer D, de Jong E K, Asztalos Z, Westwood J T, Stunnenberg H G, Sokolowski M B et al. 2011. Epigenetic regulation of learning and memory by  Drosophila  EHMT/G9a.  PLoS biology  9: e1000569. 
         64. Landt S G, Marinov G K, Kundaje A, Kheradpour P, Pauli F, Batzoglou S, Bernstein B E, Bickel P, Brown J B, Cayting P et al. 2012. ChlP-seq guidelines and practices of the ENCODE and modENCODE consortia.  Genome research  22: 1813-1831. 
         65. Lassmann T, Hayashizaki Y, Daub C O. 2011. SAMStat: monitoring biases in next generation sequencing data.  Bioinformatics  27: 130-131. 
         66. Li H, Ruan J, Durbin R. 2008. Mapping short DNA sequencing reads and calling variants using mapping quality scores.  Genome research  18: 1851-1858. 
         67. Mortazavi A, Williams B A, McCue K, Schaeffer L, Wold B. 2008. Mapping and quantifying mammalian transcriptomes by RNA-Seq.  Nat Methods  5: 621-628. 
         68. Pico A R, Kelder T, van lersel M P, Hanspers K, Conklin B R, Evelo C. 2008. WikiPathways: pathway editing for the people.  PLoS biology  6: el 84. 
         69. Ring A, Mineyev N, Zhu W, Park E, Lomas C, Punj V, Yu M, Barrak D, Forte V, Porras T et al. 2015. EpCAM based capture detects and recovers circulating tumor cells from all subtypes of breast cancer except claudin-low.  Oncotarget.    
         70. Shen L, Shao N, Liu X, Nestler E. 2014. ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases.  BMC genomics  15: 284. 
         71. Ye T, Krebs A R, Choukrallah M A, Keime C, Plewniak F, Davidson I, Tora L. 2011. seqMINER: an integrated ChIP-seq data interpretation platform.  Nucleic acids research  39: e35. 
       
    
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                   
                   
                   
                   
                 Differential 
                   
                   
                 MMP9sh vs 
               
               
                   
                   
                   
                   
                 expressin 
                 MMP-9sh 3d 
                 NCsh 3d 
                 NCsh (log2 
               
               
                 Gene 
                 p-value 
                 ID 
                 Description 
                 (log2 ratio) 
                 RANKL 
                 RNAKL 
                 ratio) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Tspan10 
                 5.83763E−08 
                 ENSMUSG00000039691 
                 tetraspanin 
                 −7.4485833 
                 −5.3956246 
                 2.0529587 
                 −7.4485833 
               
               
                   
                   
                   
                 10 
               
               
                 Gm13057 
                 3.0793E−06 
                 ENSMUSG00000078514 
                 predicted 
                 −7.171078 
                 −5.5476274 
                 1.6234506 
                 −7.171078 
               
               
                   
                   
                   
                 gene 13057 
               
               
                 Gm13040 
                 7.74498E−05 
                 ENSMUSG00000070616 
                 predicted 
                 −7.171078 
                 −5.5476274 
                 1.6234506 
                 −7.171078 
               
               
                   
                   
                   
                 gene 13040 
               
               
                 Rhov 
                 3.82912E−06 
                 ENSMUSG00000034226 
                 ras homolog 
                 −6.6498415 
                 −5.3956246 
                 1.2542169 
                 −6.6498415 
               
               
                   
                   
                   
                 gene family, 
               
               
                   
                   
                   
                 member V 
               
               
                 Itgb3 
                 0.000171214 
                 ENSMUSG00000020689 
                 integrin beta 3 
                 −6.5923559 
                 −1.0736963 
                 5.5186596 
                 −6.5923559 
               
               
                 Matk 
                 0.000250093 
                 ENSMUSG00000004933 
                 megakaryocyte- 
                 −6.4593418 
                 −2.3956244 
                 4.0637174 
                 −6.4593418 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 tyrosine 
               
               
                   
                   
                   
                 kinase 
               
               
                 Ctsk 
                 0.000214337 
                 ENSMUSG00000028111 
                 cathepsin K 
                 −6.446837 
                 5.423756 
                 11.870593 
                 −6.446837 
               
               
                 Cldn11 
                 7.28667E−05 
                 ENSMUSG00000037625 
                 claudin 11 
                 −5.5788259 
                 −0.2256994 
                 5.3531265 
                 −5.5788259 
               
               
                 Bai1 
                 0.000475161 
                 ENSMUSG00000034730 
                 brain-specific 
                 −5.4648093 
                 −5.5476274 
                 −0.0828181 
                 −5.4648093 
               
               
                   
                   
                   
                 angiogenesis 
               
               
                   
                   
                   
                 inhibitor 1 
               
               
                 Htr1b 
                 6.37744E−05 
                 ENSMUSG00000049511 
                 5- 
                 −5.4282835 
                 −2.8106618 
                 2.6176217 
                 −5.4282835 
               
               
                   
                   
                   
                 hydroxytryptamine 
               
               
                   
                   
                   
                 (serotonin) 
               
               
                   
                   
                   
                 receptor 1B 
               
               
                 D430036J16Rik 
                 0.000806317 
                 ENSMUSG00000085832 
                 RIKEN cDNA 
                 −5.2213831 
                 −2.8106618 
                 2.4107213 
                 −5.2213831 
               
               
                   
                   
                   
                 D430036J16 
               
               
                   
                   
                   
                 gene 
               
               
                 Lif 
                 0.00083463 
                 ENSMUSG00000034394 
                 leukemia 
                 −5.2032929 
                 −0.6407369 
                 4.562556 
                 −5.2032929 
               
               
                   
                   
                   
                 inhibitory 
               
               
                   
                   
                   
                 factor 
               
               
                 Gm1123 
                 0.013656123 
                 ENSMUSG00000044860 
                 predicted 
                 −5.1941621 
                 −5.3956246 
                 −0.2014625 
                 −5.1941621 
               
               
                   
                   
                   
                 gene 1123 
               
               
                 Gm10696 
                 0.015074948 
                 ENSMUSG00000074424 
                 predicted 
                 −5.1710781 
                 −5.5476274 
                 −0.3765493 
                 −5.1710781 
               
               
                   
                   
                   
                 gene 10696 
               
               
                 Mmp9 
                 5.50763E−09 
                 ENSMUSG00000017737 
                 matrix 
                 −5.1696789 
                 1.9531038 
                 7.1227827 
                 −5.1696789 
               
               
                   
                   
                   
                 metallopeptidase 9 
               
               
                 Gm15448 
                 0.002977603 
                 ENSMUSG00000074419 
                 predicted 
                 −5.1237725 
                 −3.8106618 
                 1.3131107 
                 −5.1237725 
               
               
                   
                   
                   
                 gene 15448 
               
               
                 Mapk4 
                 0.016108619 
                 ENSMUSG00000024558 
                 mitogen- 
                 −5.1237724 
                 −5.5476274 
                 −0.423855 
                 −5.1237724 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 kinase 4 
               
               
                 Zscan4c 
                 0.017287914 
                 ENSMUSG00000054272 
                 zinc finger 
                 −5.1092732 
                 −5.3956246 
                 −0.2863514 
                 −5.1092732 
               
               
                   
                   
                   
                 and SCAN 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 4C 
               
               
                 Gm13119 
                 0.000839543 
                 ENSMUSG00000070619 
                 predicted 
                 −5.0748629 
                 −5.5476274 
                 −0.4727645 
                 −5.0748629 
               
               
                   
                   
                   
                 gene 13119 
               
               
                 Atp2b3 
                 0.017654449 
                 ENSMUSG00000031376 
                 ATPase, Ca++ 
                 −5.0748629 
                 −5.5476274 
                 −0.4727645 
                 −5.0748629 
               
               
                   
                   
                   
                 transporting, 
               
               
                   
                   
                   
                 plasma 
               
               
                   
                   
                   
                 membrane 3 
               
               
                 Prss46 
                 0.005045636 
                 ENSMUSG00000049719 
                 protease, 
                 −5.0497718 
                 −2.8106618 
                 2.23911 
                 −5.0497718 
               
               
                   
                   
                   
                 serine, 46 
               
               
                 Ccr3 
                 0.000166384 
                 ENSMUSG00000035448 
                 chemokine 
                 −5.0467314 
                 −2.0736964 
                 2.973035 
                 −5.0467314 
               
               
                   
                   
                   
                 (C-C motif) 
               
               
                   
                   
                   
                 receptor 3 
               
               
                 Dgki 
                 0.000827937 
                 ENSMUSG00000038665 
                 diacylglycerol 
                 −5.0345051 
                 −2.8106618 
                 2.2238433 
                 −5.0345051 
               
               
                   
                   
                   
                 kinase, iota 
               
               
                 Gm7971 
                 0.01710386 
                 ENSMUSG00000079422 
                 predicted 
                 −5.0242368 
                 −5.5476274 
                 −0.5233907 
                 −5.0242368 
               
               
                   
                   
                   
                 gene 7971 
               
               
                 Gm16429 
                 0.01720231 
                 ENSMUSG00000072823 
                 predicted 
                 −5.0242368 
                 −5.5476274 
                 −0.5233907 
                 −5.0242368 
               
               
                   
                   
                   
                 gene 16429 
               
               
                 Opcml 
                 0.014594807 
                 ENSMUSG00000062257 
                 opioid 
                 −5.0190754 
                 −4.3956246 
                 0.62345076 
                 −5.0190754 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein/cell 
               
               
                   
                   
                   
                 adhesion 
               
               
                   
                   
                   
                 molecule-like 
               
               
                 Zscan4d 
                 2.03004E−05 
                 ENSMUSG00000090714 
                 zinc finger 
                 −5.0190753 
                 −5.3956246 
                 −0.3765493 
                 −5.0190753 
               
               
                   
                   
                   
                 and SCAN 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 4D 
               
               
                 Mtus1 
                 0.014655925 
                 ENSMUSG00000045636 
                 mitochondrial 
                 −5.0190753 
                 −5.3956246 
                 −0.3765493 
                 −5.0190753 
               
               
                   
                   
                   
                 tumor 
               
               
                   
                   
                   
                 suppressor 1 
               
               
                 Fam198b 
                 1.55975E−08 
                 ENSMUSG00000027955 
                 family with 
                 −5.003479 
                 1.54689 
                 6.550369 
                 −5.003479 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 similarity 198, 
               
               
                   
                   
                   
                 member B 
               
               
                 Chst1 
                 0.015000206 
                 ENSMUSG00000027221 
                 carbohydrate 
                 −4.9956165 
                 −4.3956246 
                 0.59999186 
                 −4.9956165 
               
               
                   
                   
                   
                 (keratan 
               
               
                   
                   
                   
                 sulfate Gal-6) 
               
               
                   
                   
                   
                 sulfotransferase 1 
               
               
                 Calml4 
                 0.001680683 
                 ENSMUSG00000032246 
                 calmodulin- 
                 −4.977103 
                 −2.2256994 
                 2.7514036 
                 −4.977103 
               
               
                   
                   
                   
                 like 4 
               
               
                 H1foo 
                 0.000716847 
                 ENSMUSG00000042279 
                 H1 histone 
                 −4.9717696 
                 −5.3956246 
                 −0.423855 
                 −4.9717696 
               
               
                   
                   
                   
                 family, 
               
               
                   
                   
                   
                 member O, 
               
               
                   
                   
                   
                 oocyte- 
               
               
                   
                   
                   
                 specific 
               
               
                 Gm10424 
                 0.014855926 
                 ENSMUSG00000072817 
                 predicted 
                 −4.9717696 
                 −5.3956246 
                 −0.423855 
                 −4.9717696 
               
               
                   
                   
                   
                 gene 10424 
               
               
                 Ttll11 
                 0.015697744 
                 ENSMUSG00000026885 
                 tubulin 
                 −4.9717696 
                 −5.3956246 
                 −0.423855 
                 −4.9717696 
               
               
                   
                   
                   
                 tyrosine 
               
               
                   
                   
                   
                 ligase-like 
               
               
                   
                   
                   
                 family, 
               
               
                   
                   
                   
                 member 11 
               
               
                 Ppef2 
                 0.015779987 
                 ENSMUSG00000029410 
                 protein 
                 −4.9717696 
                 −5.3956246 
                 −0.423855 
                 −4.9717696 
               
               
                   
                   
                   
                 phosphatase, 
               
               
                   
                   
                   
                 EF hand 
               
               
                   
                   
                   
                 calcium- 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 domain 2 
               
               
                 D930048N14Rik 
                 0.015629802 
                 ENSMUSG00000052563 
                 RIKEN cDNA 
                 −4.9717696 
                 −4.3956246 
                 0.576145 
                 −4.9717696 
               
               
                   
                   
                   
                 D930048N14 
               
               
                   
                   
                   
                 gene 
               
               
                 Slc4a3 
                 0.01688572 
                 ENSMUSG00000006576 
                 solute carrier 
                 −4.9717693 
                 −5.5476274 
                 −0.5758581 
                 −4.9717693 
               
               
                   
                   
                   
                 family 4 
               
               
                   
                   
                   
                 (anion 
               
               
                   
                   
                   
                 exchanger), 
               
               
                   
                   
                   
                 member 3 
               
               
                 BC061212 
                 0.017009392 
                 ENSMUSG00000072822 
                 cDNA 
                 −4.9717693 
                 −5.5476274 
                 −0.5758581 
                 −4.9717693 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 BC061212 
               
               
                 Ccr1 
                 1.08715E−10 
                 ENSMUSG00000025804 
                 chemokine 
                 −4.9647516 
                 1.9081564 
                 6.872908 
                 −4.9647516 
               
               
                   
                   
                   
                 (C-C motif) 
               
               
                   
                   
                   
                 receptor 1 
               
               
                 Rtkn2 
                 9.62021E−10 
                 ENSMUSG00000037846 
                 rhotekin 2 
                 −4.9173215 
                 −5.5476274 
                 −0.6303059 
                 −4.9173215 
               
               
                 Plxna4 
                 0.017766215 
                 ENSMUSG00000029765 
                 plexin A4 
                 −4.9173215 
                 −5.5476274 
                 −0.6303059 
                 −4.9173215 
               
               
                 Mpzl3 
                 0.000349792 
                 ENSMUSG00000070305 
                 myelin 
                 −4.8696551 
                 −1.0736963 
                 3.7959588 
                 −4.8696551 
               
               
                   
                   
                   
                 protein zero- 
               
               
                   
                   
                   
                 like 3 
               
               
                 C77080 
                 4.56735E−08 
                 ENSMUSG00000050390 
                 expressed 
                 −4.8508598 
                 2.1512702 
                 7.00213 
                 −4.8508598 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 C77080 
               
               
                 Ano7 
                 0.005485625 
                 ENSMUSG00000034107 
                 anoctamin 7 
                 −4.8349529 
                 −2.5882695 
                 2.2466834 
                 −4.8349529 
               
               
                 Ckb 
                 3.7182E−09 
                 ENSMUSG00000001270 
                 creatine 
                 −4.8318095 
                 4.1141505 
                 8.94596 
                 −4.8318095 
               
               
                   
                   
                   
                 kinase, brain 
               
               
                 Sorbs2 
                 0.005497429 
                 ENSMUSG00000031626 
                 sorbin and 
                 −4.8273795 
                 −2.5882695 
                 2.23911 
                 −4.8273795 
               
               
                   
                   
                   
                 SH3 domain 
               
               
                   
                   
                   
                 containing 2 
               
               
                 Tdp0z5 
                 0.026959086 
                 ENSMUSG00000074427 
                 TD and POZ 
                 −4.8018443 
                 −5.5476274 
                 −0.7457831 
                 −4.8018443 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 5 
               
               
                 Gm10697 
                 0.02758078 
                 ENSMUSG00000074425 
                 predicted 
                 −4.8018443 
                 −5.5476274 
                 −0.7457831 
                 −4.8018443 
               
               
                   
                   
                   
                 gene 10697 
               
               
                 Gm5286 
                 0.028164925 
                 ENSMUSG00000090268 
                 predicted 
                 −4.8018443 
                 −5.5476274 
                 −0.7457831 
                 −4.8018443 
               
               
                   
                   
                   
                 gene 5286 
               
               
                 Fam46c 
                 0.028858004 
                 ENSMUSG00000044468 
                 family with 
                 −4.8018443 
                 −5.5476274 
                 −0.7457831 
                 −4.8018443 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 similarity 46, 
               
               
                   
                   
                   
                 member C 
               
               
                 Gm6346 
                 0.029553404 
                 ENSMUSG00000091252 
                 predicted 
                 −4.8018443 
                 −5.5476274 
                 −0.7457831 
                 −4.8018443 
               
               
                   
                   
                   
                 gene 6346 
               
               
                 Cthrc1 
                 0.030250954 
                 ENSMUSG00000054196 
                 collagen 
                 −4.8018443 
                 −5.5476274 
                 −0.7457831 
                 −4.8018443 
               
               
                   
                   
                   
                 triple helix 
               
               
                   
                   
                   
                 repeat 
               
               
                   
                   
                   
                 containing 1 
               
               
                 Gm22 
                 0.003586833 
                 ENSMUSG00000043903 
                 predicted 
                 −4.7791244 
                 −2.3956244 
                 2.3835 
                 −4.7791244 
               
               
                   
                   
                   
                 gene 22 
               
               
                 Adck3 
                 4.30239E−06 
                 ENSMUSG00000026489 
                 aarF domain 
                 −4.770136 
                 1.1279377 
                 5.8980737 
                 −4.770136 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 kinase 3 
               
               
                 Tnfsf12 
                 0.000393042 
                 ENSMUSG00000090170 
                 tumor 
                 −4.7429509 
                 −3.0736964 
                 1.6692545 
                 −4.7429509 
               
               
                   
                   
                   
                 necrosis 
               
               
                   
                   
                   
                 factor (ligand) 
               
               
                   
                   
                   
                 superfamily, 
               
               
                   
                   
                   
                 member 12 
               
               
                 Gpr176 
                 0.001955719 
                 ENSMUSG00000040133 
                 G protein- 
                 −4.7408358 
                 −1.3956243 
                 3.3452115 
                 −4.7408358 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 receptor 176 
               
               
                 Gm7978 
                 0.02610885 
                 ENSMUSG00000072815 
                 predicted 
                 −4.7404438 
                 −5.5476274 
                 −0.8071836 
                 −4.7404438 
               
               
                   
                   
                   
                 gene 7978 
               
               
                 Akr1c18 
                 0.02618227 
                 ENSMUSG00000021214 
                 aldo-keto 
                 −4.7404438 
                 −5.5476274 
                 −0.8071836 
                 −4.7404438 
               
               
                   
                   
                   
                 reductase 
               
               
                   
                   
                   
                 family 1, 
               
               
                   
                   
                   
                 member C18 
               
               
                 Gm15241 
                 0.013268969 
                 ENSMUSG00000087505 
                 predicted 
                 −4.7087353 
                 −4.3956246 
                 0.31311068 
                 −4.7087353 
               
               
                   
                   
                   
                 gene 15241 
               
               
                 Eps8l2 
                 0.018382147 
                 ENSMUSG00000025504 
                 EPS8-like 2 
                 −4.7087353 
                 −4.3956246 
                 0.31311068 
                 −4.7087353 
               
               
                 Grb10 
                 0.00447582 
                 ENSMUSG00000020176 
                 growth factor 
                 −4.7087351 
                 −3.3956244 
                 1.3131107 
                 −4.7087351 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 bound 
               
               
                   
                   
                   
                 protein 10 
               
               
                 Akap6 
                 9.72033E−07 
                 ENSMUSG00000061603 
                 A kinase 
                 −4.6948978 
                 1.0638072 
                 5.758705 
                 −4.6948978 
               
               
                   
                   
                   
                 (PRKA) 
               
               
                   
                   
                   
                 anchor 
               
               
                   
                   
                   
                 protein 6 
               
               
                 Sema7a 
                 0.001981256 
                 ENSMUSG00000038264 
                 sema domain, 
                 −4.6631381 
                 −2.2256994 
                 2.4374387 
                 −4.6631381 
               
               
                   
                   
                   
                 immunoglobulin 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 (Ig), and GPI 
               
               
                   
                   
                   
                 membrane 
               
               
                   
                   
                   
                 anchor, 
               
               
                   
                   
                   
                 (semaphorin) 
               
               
                   
                   
                   
                 7A 
               
               
                 Il34 
                 0.023407776 
                 ENSMUSG00000031750 
                 interleukin 34 
                 −4.6498415 
                 −5.3956246 
                 −0.7457831 
                 −4.6498415 
               
               
                 BC050972 
                 2.2733E−05 
                 ENSMUSG00000092131 
                 cDNA 
                 −4.6498413 
                 −3.3956244 
                 1.2542169 
                 −4.6498413 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 BC050972 
               
               
                 Mras 
                 0.001684752 
                 ENSMUSG00000032470 
                 muscle and 
                 −4.6347343 
                 −1.3956243 
                 3.23911 
                 −4.6347343 
               
               
                   
                   
                   
                 microspikes 
               
               
                   
                   
                   
                 RAS 
               
               
                 Arhgap31 
                 2.67619E−08 
                 ENSMUSG00000022799 
                 Rho GTPase 
                 −4.6253586 
                 1.3048154 
                 5.930174 
                 −4.6253586 
               
               
                   
                   
                   
                 activating 
               
               
                   
                   
                   
                 protein 31 
               
               
                 Tmcc3 
                 0.012788476 
                 ENSMUSG00000020023 
                 transmembrane 
                 −4.619468 
                 −4.3956246 
                 0.22384338 
                 −4.619468 
               
               
                   
                   
                   
                 and coiled 
               
               
                   
                   
                   
                 coil domains 3 
               
               
                 BC106179 
                 0.02830728 
                 ENSMUSG00000045231 
                 cDNA 
                 −4.6091994 
                 −5.5476274 
                 −0.938428 
                 −4.6091994 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 BC106179 
               
               
                 Gabrg2 
                 0.028566783 
                 ENSMUSG00000020436 
                 gamma- 
                 −4.6091994 
                 −5.5476274 
                 −0.938428 
                 −4.6091994 
               
               
                   
                   
                   
                 aminobutyric 
               
               
                   
                   
                   
                 acid (GABA) A 
               
               
                   
                   
                   
                 receptor, 
               
               
                   
                   
                   
                 subunit 
               
               
                   
                   
                   
                 gamma 2 
               
               
                 Siglec15 
                 1.04139E−13 
                 ENSMUSG00000091055 
                 sialic acid 
                 −4.6067727 
                 −1.3081615 
                 3.2986112 
                 −4.6067727 
               
               
                   
                   
                   
                 binding Ig-like 
               
               
                   
                   
                   
                 lectin 15 
               
               
                 Cnn2 
                 0.009360389 
                 ENSMUSG00000004665 
                 calponin 2 
                 −4.6062522 
                 −2.5882695 
                 2.0179827 
                 −4.6062522 
               
               
                 Hist1h3f 
                 0.000460235 
                 ENSMUSG00000059309 
                 histone 
                 −4.588441 
                 −5.3956246 
                 −0.8071836 
                 −4.588441 
               
               
                   
                   
                   
                 cluster 1, H3f 
               
               
                 Msln 
                 0.014735865 
                 ENSMUSG00000063011 
                 mesothelin 
                 −4.588441 
                 −4.3956246 
                 0.19281639 
                 −4.588441 
               
               
                 B230206H07Rik 
                 0.015672518 
                 ENSMUSG00000086844 
                 RIKEN cDNA 
                 −4.5567322 
                 −4.3956246 
                 0.16110758 
                 −4.5567322 
               
               
                   
                   
                   
                 B230206H07 
               
               
                   
                   
                   
                 gene 
               
               
                 Zscan4b 
                 0.028859515 
                 ENSMUSG00000091643 
                 zinc finger 
                 −4.53881 
                 −5.5476274 
                 −1.0088174 
                 −4.53881 
               
               
                   
                   
                   
                 and SCAN 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 4B 
               
               
                 Gm7682 
                 0.029196529 
                 ENSMUSG00000074011 
                 predicted 
                 −4.53881 
                 −5.5476274 
                 −1.0088174 
                 −4.53881 
               
               
                   
                   
                   
                 gene 7682 
               
               
                 Gm6468 
                 0.029204158 
                 ENSMUSG00000072816 
                 predicted 
                 −4.53881 
                 −5.5476274 
                 −1.0088174 
                 −4.53881 
               
               
                   
                   
                   
                 gene 6468 
               
               
                 Gpr64 
                 0.034004346 
                 ENSMUSG00000031298 
                 G protein- 
                 −4.5243106 
                 −5.3956246 
                 −0.871314 
                 −4.5243106 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 receptor 64 
               
               
                 Cfhr2 
                 0.002030646 
                 ENSMUSG00000033898 
                 complement 
                 −4.5111351 
                 −1.4887338 
                 3.0224013 
                 −4.5111351 
               
               
                   
                   
                   
                 factor H- 
               
               
                   
                   
                   
                 related 2 
               
               
                 Myocd 
                 0.034741744 
                 ENSMUSG00000020542 
                 myocardin 
                 −4.4648094 
                 −5.5476274 
                 −1.082818 
                 −4.4648094 
               
               
                 Gm7982 
                 0.03488961 
                 ENSMUSG00000072814 
                 predicted 
                 −4.4648094 
                 −5.5476274 
                 −1.082818 
                 −4.4648094 
               
               
                   
                   
                   
                 gene 7982 
               
               
                 Gm6509 
                 0.035009217 
                 ENSMUSG00000074008 
                 predicted 
                 −4.4648094 
                 −5.5476274 
                 −1.082818 
                 −4.4648094 
               
               
                   
                   
                   
                 gene 6509 
               
               
                 Gm6502 
                 0.03512885 
                 ENSMUSG00000073498 
                 predicted 
                 −4.4648094 
                 −5.5476274 
                 −1.082818 
                 −4.4648094 
               
               
                   
                   
                   
                 gene 6502 
               
               
                 Gm6351 
                 0.035928585 
                 ENSMUSG00000072821 
                 predicted 
                 −4.4648094 
                 −5.5476274 
                 −1.082818 
                 −4.4648094 
               
               
                   
                   
                   
                 gene 6351 
               
               
                 Slc18a1 
                 1.86529E−06 
                 ENSMUSG00000036330 
                 solute carrier 
                 −4.4627261 
                 0.55857193 
                 5.021298 
                 −4.4627261 
               
               
                   
                   
                   
                 family 18 
               
               
                   
                   
                   
                 (vesicular 
               
               
                   
                   
                   
                 monoamine), 
               
               
                   
                   
                   
                 member 1 
               
               
                 Rnf165 
                 0.03428333 
                 ENSMUSG00000025427 
                 ring finger 
                 −4.4571966 
                 −5.3956246 
                 −0.938428 
                 −4.4571966 
               
               
                   
                   
                   
                 protein 165 
               
               
                 Hist1h3b 
                 0.03678912 
                 ENSMUSG00000069267 
                 histone 
                 −4.4571966 
                 −5.3956246 
                 −0.938428 
                 −4.4571966 
               
               
                   
                   
                   
                 cluster 1, H3b 
               
               
                 Nos1ap 
                 9.11868E−06 
                 ENSMUSG00000038473 
                 nitric oxide 
                 −4.3043447 
                 −5.5476274 
                 −1.2432827 
                 −4.3043447 
               
               
                   
                   
                   
                 synthase 1 
               
               
                   
                   
                   
                 (neuronal) 
               
               
                   
                   
                   
                 adaptor 
               
               
                   
                   
                   
                 protein 
               
               
                 AA986860 
                 2.02175E−11 
                 ENSMUSG00000042510 
                 expressed 
                 −4.1523419 
                 −5.3956246 
                 −1.2432827 
                 −4.1523419 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 AA986860 
               
               
                 Dmrtb1 
                 4.996E−16 
                 ENSMUSG00000028610 
                 DMRT-like 
                 −4.1237723 
                 −5.5476274 
                 −1.4238551 
                 −4.1237723 
               
               
                   
                   
                   
                 family B with 
               
               
                   
                   
                   
                 proline-rich 
               
               
                   
                   
                   
                 C-terminal, 1 
               
               
                 Apoa5 
                 5.2547E−06 
                 ENSMUSG00000032079 
                 apolipoprotein 
                 −4.0648791 
                 −5.3956246 
                 −1.3307455 
                 −4.0648791 
               
               
                   
                   
                   
                 A-V 
               
               
                 Sphk1 
                 0.000200649 
                 ENSMUSG00000061878 
                 sphingosine 
                 −4.0097374 
                 −2.0736964 
                 1.936041 
                 −4.0097374 
               
               
                   
                   
                   
                 kinase 1 
               
               
                 Acp5 
                 0.001185123 
                 ENSMUSG00000001348 
                 acid 
                 −4.0066 
                 6.829583 
                 10.836183 
                 −4.0066 
               
               
                   
                   
                   
                 phosphatase 
               
               
                   
                   
                   
                 5, tartrate 
               
               
                   
                   
                   
                 resistant 
               
               
                 Calcr 
                 1.58852E−06 
                 ENSMUSG00000023964 
                 calcitonin 
                 −3.9956162 
                 −2.3956244 
                 1.5999918 
                 −3.9956162 
               
               
                   
                   
                   
                 receptor 
               
               
                 E130309D14Rik 
                 0.00390218 
                 ENSMUSG00000069814 
                 RIKEN cDNA 
                 −3.9717695 
                 −5.3956246 
                 −1.4238551 
                 −3.9717695 
               
               
                   
                   
                   
                 E130309D14 
               
               
                   
                   
                   
                 gene 
               
               
                 Gm3176 
                 0.004518255 
                 ENSMUSG00000073509 
                 predicted 
                 −3.9228601 
                 −4.3956246 
                 −0.4727645 
                 −3.9228601 
               
               
                   
                   
                   
                 gene 3176 
               
               
                 Kirrel2 
                 0.000108978 
                 ENSMUSG00000036915 
                 kin of IRRE 
                 −3.9173215 
                 −5.5476274 
                 −1.6303059 
                 −3.9173215 
               
               
                   
                   
                   
                 like 2 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Gm4788 
                 0.00511082 
                 ENSMUSG00000070594 
                 predicted 
                 −3.9157354 
                 −2.5882695 
                 1.3274659 
                 −3.9157354 
               
               
                   
                   
                   
                 gene 4788 
               
               
                 AI661453 
                 6.6252E−10 
                 ENSMUSG00000034382 
                 expressed 
                 −3.8722339 
                 −5.3956246 
                 −1.5233907 
                 −3.8722339 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 AI661453 
               
               
                 Mrgpre 
                 1.63355E−07 
                 ENSMUSG00000048965 
                 MAS-related 
                 −3.8722339 
                 −5.3956246 
                 −1.5233907 
                 −3.8722339 
               
               
                   
                   
                   
                 GPR, member E 
               
               
                 Fam109a 
                 0.003682157 
                 ENSMUSG00000044134 
                 family with 
                 −3.8686511 
                 3.3592632 
                 7.2279143 
                 −3.8686511 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 similarity 109, 
               
               
                   
                   
                   
                 member A 
               
               
                 Nos1 
                 0.002229427 
                 ENSMUSG00000029361 
                 nitric oxide 
                 −3.8462386 
                 −3.3956244 
                 0.45061424 
                 −3.8462386 
               
               
                   
                   
                   
                 synthase 1, 
               
               
                   
                   
                   
                 neuronal 
               
               
                 Ggt1 
                 0.007170915 
                 ENSMUSG00000006345 
                 gamma- 
                 −3.8197665 
                 −4.3956246 
                 −0.5758581 
                 −3.8197665 
               
               
                   
                   
                   
                 glutamyltransferase 1 
               
               
                 Pramef6 
                 0.006200188 
                 ENSMUSG00000078512 
                 PRAME family 
                 −3.8018444 
                 −5.5476274 
                 −1.745783 
                 −3.8018444 
               
               
                   
                   
                   
                 member 6 
               
               
                 Lilra6 
                 0.001267628 
                 ENSMUSG00000030427 
                 leukocyte 
                 −3.7810859 
                 −2.5882695 
                 1.1928164 
                 −3.7810859 
               
               
                   
                   
                   
                 immunoglobulin- 
               
               
                   
                   
                   
                 like 
               
               
                   
                   
                   
                 receptor, 
               
               
                   
                   
                   
                 subfamily A 
               
               
                   
                   
                   
                 (with TM 
               
               
                   
                   
                   
                 domain), 
               
               
                   
                   
                   
                 member 6 
               
               
                 Gm10527 
                 0.001781571 
                 ENSMUSG00000073525 
                 predicted 
                 −3.7653187 
                 −5.3956246 
                 −1.6303059 
                 −3.7653187 
               
               
                   
                   
                   
                 gene 10527 
               
               
                 Gc 
                 0.010909459 
                 ENSMUSG00000035540 
                 group specific 
                 −3.7653187 
                 −5.3956246 
                 −1.6303059 
                 −3.7653187 
               
               
                   
                   
                   
                 component 
               
               
                 Cyp26b1 
                 0.00299968 
                 ENSMUSG00000063415 
                 cytochrome 
                 −3.6763135 
                 −5.5476274 
                 −1.8713139 
                 −3.6763135 
               
               
                   
                   
                   
                 P450, family 
               
               
                   
                   
                   
                 26, subfamily 
               
               
                   
                   
                   
                 b, 
               
               
                   
                   
                   
                 polypeptide 1 
               
               
                 Krba1 
                 0.006188563 
                 ENSMUSG00000042810 
                 KRAB-A 
                 −3.6763135 
                 −5.5476274 
                 −1.8713139 
                 −3.6763135 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 1 
               
               
                 E230008N13Rik 
                 0.010172137 
                 ENSMUSG00000035539 
                 RIKEN cDNA 
                 −3.6763135 
                 −5.5476274 
                 −1.8713139 
                 −3.6763135 
               
               
                   
                   
                   
                 E230008N13 
               
               
                   
                   
                   
                 gene 
               
               
                 Clec4b1 
                 5.68695E−05 
                 ENSMUSG00000030147 
                 C-type lectin 
                 −3.6624414 
                 −1.1476969 
                 2.5147445 
                 −3.6624414 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 family 4, 
               
               
                   
                   
                   
                 member b1 
               
               
                 Src 
                 0.001090707 
                 ENSMUSG00000027646 
                 Rous sarcoma 
                 −3.651526 
                 4.082134 
                 7.73366 
                 −3.651526 
               
               
                   
                   
                   
                 oncogene 
               
               
                 Lrp2bp 
                 0.013656123 
                 ENSMUSG00000031637 
                 Lrp2 binding 
                 −3.588441 
                 −4.3956246 
                 −0.8071836 
                 −3.588441 
               
               
                   
                   
                   
                 protein 
               
               
                 Plekhg5 
                 5.50763E−09 
                 ENSMUSG00000039713 
                 pleckstrin 
                 −3.5700286 
                 0.18933822 
                 3.7593668 
                 −3.5700286 
               
               
                   
                   
                   
                 homology 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing, 
               
               
                   
                   
                   
                 family G (with 
               
               
                   
                   
                   
                 RhoGef 
               
               
                   
                   
                   
                 domain) 
               
               
                   
                   
                   
                 member 5 
               
               
                 1700019D03Rik 
                 0.002977603 
                 ENSMUSG00000043629 
                 RIKEN cDNA 
                 −3.53881 
                 −5.5476274 
                 −2.0088174 
                 −3.53881 
               
               
                   
                   
                   
                 1700019D03 
               
               
                   
                   
                   
                 gene 
               
               
                 Rnf43 
                 0.017287914 
                 ENSMUSG00000034177 
                 ring finger 
                 −3.5243107 
                 −5.3956246 
                 −1.8713139 
                 −3.5243107 
               
               
                   
                   
                   
                 protein 43 
               
               
                 Tmem220 
                 0.017654449 
                 ENSMUSG00000050270 
                 transmembrane 
                 −3.5243107 
                 −5.3956246 
                 −1.8713139 
                 −3.5243107 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 220 
               
               
                 Ak1 
                 0.000166384 
                 ENSMUSG00000026817 
                 adenylate 
                 −3.4884204 
                 −0.186171 
                 3.3022494 
                 −3.4884204 
               
               
                   
                   
                   
                 kinase 1 
               
               
                 Wipi1 
                 0.005311127 
                 ENSMUSG00000041895 
                 WD repeat 
                 −3.461769 
                 −1.4887338 
                 1.9730352 
                 −3.461769 
               
               
                   
                   
                   
                 domain, 
               
               
                   
                   
                   
                 phosphoinositide 
               
               
                   
                   
                   
                 interacting 1 
               
               
                 Ndrg4 
                 0.01720231 
                 ENSMUSG00000036564 
                 N-myc 
                 −3.4556536 
                 3.251834 
                 6.7074876 
                 −3.4556536 
               
               
                   
                   
                   
                 downstream 
               
               
                   
                   
                   
                 regulated 
               
               
                   
                   
                   
                 gene 4 
               
               
                 Mmp14 
                 0.01710386 
                 ENSMUSG00000000957 
                 matrix 
                 −3.4256262 
                 −1.9361928 
                 1.4894334 
                 −3.4256262 
               
               
                   
                   
                   
                 metallopeptidase 
               
               
                   
                   
                   
                 14 
               
               
                   
                   
                   
                 (membrane- 
               
               
                   
                   
                   
                 inserted) 
               
               
                 Gpr56 
                 0.014594807 
                 ENSMUSG00000031785 
                 G protein- 
                 −3.3868072 
                 −5.3956246 
                 −2.0088174 
                 −3.3868072 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 receptor 56 
               
               
                 Pira5 
                 0.014655925 
                 ENSMUSG00000074417 
                 paired-Ig-like 
                 −3.3868071 
                 −2.0736964 
                 1.3131107 
                 −3.3868071 
               
               
                   
                   
                   
                 receptor A5 
               
               
                 Gm13083 
                 1.55975E−08 
                 ENSMUSG00000066688 
                 predicted 
                 −3.3868069 
                 −5.5476274 
                 −2.1608205 
                 −3.3868069 
               
               
                   
                   
                   
                 gene 13083 
               
               
                 Smtnl2 
                 0.001680683 
                 ENSMUSG00000045667 
                 smoothelin- 
                 −3.3868069 
                 −5.5476274 
                 −2.1608205 
                 −3.3868069 
               
               
                   
                   
                   
                 like 2 
               
               
                 Hist1h1a 
                 0.014855926 
                 ENSMUSG00000049539 
                 histone 
                 −3.3868069 
                 −5.5476274 
                 −2.1608205 
                 −3.3868069 
               
               
                   
                   
                   
                 cluster 1, H1a 
               
               
                 Abcc2 
                 0.015697744 
                 ENSMUSG00000025194 
                 ATP-binding 
                 −3.3868069 
                 −5.5476274 
                 −2.1608205 
                 −3.3868069 
               
               
                   
                   
                   
                 cassette, sub- 
               
               
                   
                   
                   
                 family C 
               
               
                   
                   
                   
                 (CFTR/MRP), 
               
               
                   
                   
                   
                 member 2 
               
               
                 Lctl 
                 0.01688572 
                 ENSMUSG00000032401 
                 lactase-like 
                 −3.3352765 
                 0.43726566 
                 3.7725422 
                 −3.3352765 
               
               
                 Xpr1 
                 0.017009392 
                 ENSMUSG00000026469 
                 xenotropic 
                 −3.3232984 
                 5.5578446 
                 8.881143 
                 −3.3232984 
               
               
                   
                   
                   
                 and 
               
               
                   
                   
                   
                 polytropic 
               
               
                   
                   
                   
                 retrovirus 
               
               
                   
                   
                   
                 receptor 1 
               
               
                 41701 
                 1.08715E−10 
                 ENSMUSG00000032656 
                 membrane- 
                 −3.3128066 
                 −4.3956246 
                 −1.082818 
                 −3.3128066 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 ring finger 
               
               
                   
                   
                   
                 (C3HC4) 3 
               
               
                 Adcy3 
                 0.017891841 
                 ENSMUSG00000020654 
                 adenylate 
                 −3.2208839 
                 0.94422567 
                 4.1651096 
                 −3.2208839 
               
               
                   
                   
                   
                 cyclase 3 
               
               
                 Cfhr1 
                 0.000349792 
                 ENSMUSG00000057037 
                 complement 
                 −3.2168819 
                 −5.5476274 
                 −2.3307455 
                 −3.2168819 
               
               
                   
                   
                   
                 factor H- 
               
               
                   
                   
                   
                 related 1 
               
               
                 Tal2 
                 0.005485625 
                 ENSMUSG00000028417 
                 T-cell acute 
                 −3.2168819 
                 −5.5476274 
                 −2.3307455 
                 −3.2168819 
               
               
                   
                   
                   
                 lymphocytic 
               
               
                   
                   
                   
                 leukemia 2 
               
               
                 Cyr61 
                 0.005497429 
                 ENSMUSG00000028195 
                 cysteine rich 
                 −3.2168819 
                 −5.5476274 
                 −2.3307455 
                 −3.2168819 
               
               
                   
                   
                   
                 protein 61 
               
               
                 Ltbp2 
                 0.030250954 
                 ENSMUSG00000002020 
                 latent 
                 −3.2023825 
                 −2.0736964 
                 1.1286861 
                 −3.2023825 
               
               
                   
                   
                   
                 transforming 
               
               
                   
                   
                   
                 growth factor 
               
               
                   
                   
                   
                 beta binding 
               
               
                   
                   
                   
                 protein 2 
               
               
                 Adamts14 
                 0.026959086 
                 ENSMUSG00000059901 
                 a disintegrin- 
                 −3.1987347 
                 −2.2256994 
                 0.9730353 
                 −3.1987347 
               
               
                   
                   
                   
                 like and 
               
               
                   
                   
                   
                 metallopeptidase 
               
               
                   
                   
                   
                 (reprolysin 
               
               
                   
                   
                   
                 type) with 
               
               
                   
                   
                   
                 thrombospondin 
               
               
                   
                   
                   
                 type 1 
               
               
                   
                   
                   
                 motif, 14 
               
               
                 Dnm1 
                 0.02758078 
                 ENSMUSG00000026825 
                 dynamin 1 
                 −3.1965845 
                 −1.3081615 
                 1.888423 
                 −3.1965845 
               
               
                 Pltp 
                 0.029553404 
                 ENSMUSG00000017754 
                 phospholipid 
                 −3.165339 
                 2.4747405 
                 5.6400795 
                 −3.165339 
               
               
                   
                   
                   
                 transfer 
               
               
                   
                   
                   
                 protein 
               
               
                 Ggt6 
                 1.80877E−07 
                 ENSMUSG00000040471 
                 gamma- 
                 −3.0648791 
                 −5.3956246 
                 −2.3307455 
                 −3.0648791 
               
               
                   
                   
                   
                 glutamyltransferase 6 
               
               
                 Grin2d 
                 0.028858004 
                 ENSMUSG00000002771 
                 glutamate 
                 −3.0648791 
                 −4.3956246 
                 −1.3307455 
                 −3.0648791 
               
               
                   
                   
                   
                 receptor, 
               
               
                   
                   
                   
                 ionotropic, 
               
               
                   
                   
                   
                 NMDA2D 
               
               
                   
                   
                   
                 (epsilon 4) 
               
               
                 Amz1 
                 0.001955719 
                 ENSMUSG00000050022 
                 archaelysin 
                 −3.0345052 
                 0.5112662 
                 3.5457714 
                 −3.0345052 
               
               
                   
                   
                   
                 family 
               
               
                   
                   
                   
                 metallopeptidase 1 
               
               
                 Otx1 
                 0.02610885 
                 ENSMUSG00000005917 
                 orthodenticle 
                 −3.0345052 
                 −2.8106618 
                 0.22384338 
                 −3.0345052 
               
               
                   
                   
                   
                 homolog 1 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Lrrn4 
                 0.001981256 
                 ENSMUSG00000043110 
                 leucine rich 
                 −3.0242366 
                 −5.5476274 
                 −2.5233908 
                 −3.0242366 
               
               
                   
                   
                   
                 repeat 
               
               
                   
                   
                   
                 neuronal 4 
               
               
                 Bpi 
                 0.00447582 
                 ENSMUSG00000052922 
                 bactericidal 
                 −3.0242366 
                 −5.5476274 
                 −2.5233908 
                 −3.0242366 
               
               
                   
                   
                   
                 permeablility 
               
               
                   
                   
                   
                 increasing 
               
               
                   
                   
                   
                 protein 
               
               
                 Kctd19 
                 0.018382147 
                 ENSMUSG00000051648 
                 potassium 
                 −3.0242366 
                 −5.5476274 
                 −2.5233908 
                 −3.0242366 
               
               
                   
                   
                   
                 channel 
               
               
                   
                   
                   
                 tetramerisation 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 19 
               
               
                 Lipg 
                 0.005540829 
                 ENSMUSG00000053846 
                 lipase, 
                 −3.0034782 
                 −2.8106618 
                 0.19281639 
                 −3.0034782 
               
               
                   
                   
                   
                 endothelial 
               
               
                 Acaa2 
                 2.67619E−08 
                 ENSMUSG00000036880 
                 acetyl- 
                 −2.9547184 
                 3.5845153 
                 6.5392337 
                 −2.9547184 
               
               
                   
                   
                   
                 Coenzyme A 
               
               
                   
                   
                   
                 acyltransferase 2 
               
               
                   
                   
                   
                 (mitochondrial 
               
               
                   
                   
                   
                 3-oxoacyl- 
               
               
                   
                   
                   
                 Coenzyme A 
               
               
                   
                   
                   
                 thiolase) 
               
               
                 2410066E13Rik 
                 0.012788476 
                 ENSMUSG00000038065 
                 RIKEN cDNA 
                 −2.8722339 
                 −4.3956246 
                 −1.5233907 
                 −2.8722339 
               
               
                   
                   
                   
                 2410066E13 
               
               
                   
                   
                   
                 gene 
               
               
                 Dlg2 
                 0.009360389 
                 ENSMUSG00000052572 
                 discs, large 
                 −2.8722338 
                 −5.3956246 
                 −2.5233908 
                 −2.8722338 
               
               
                   
                   
                   
                 homolog 2 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 2810405K02Rik 
                 0.014735865 
                 ENSMUSG00000029059 
                 RIKEN cDNA 
                 −2.8722338 
                 −5.3956246 
                 −2.5233908 
                 −2.8722338 
               
               
                   
                   
                   
                 2810405K02 
               
               
                   
                   
                   
                 gene 
               
               
                 Gm20442 
                 0.02830728 
                 ENSMUSG00000092600 
                 predicted 
                 −2.8722338 
                 −5.3956246 
                 −2.5233908 
                 −2.8722338 
               
               
                   
                   
                   
                 gene 20442 
               
               
                 Gja1 
                 0.029196529 
                 ENSMUSG00000050953 
                 gap junction 
                 −2.8416021 
                 −0.3081615 
                 2.5334406 
                 −2.8416021 
               
               
                   
                   
                   
                 protein, alpha 1 
               
               
                 Hist1h4n 
                 0.029204158 
                 ENSMUSG00000069305 
                 histone 
                 −2.8018444 
                 −3.8106618 
                 −1.0088174 
                 −2.8018444 
               
               
                   
                   
                   
                 cluster 1, H4n 
               
               
                 Cd28 
                 0.034004346 
                 ENSMUSG00000026012 
                 CD28 antigen 
                 −2.8018444 
                 −5.5476274 
                 −2.745783 
                 −2.8018444 
               
               
                 Carns1 
                 0.034741744 
                 ENSMUSG00000075289 
                 carnosine 
                 −2.8018444 
                 −5.5476274 
                 −2.745783 
                 −2.8018444 
               
               
                   
                   
                   
                 synthase 1 
               
               
                 Wnt9a 
                 0.035009217 
                 ENSMUSG00000000126 
                 wingless-type 
                 −2.8018444 
                 −5.5476274 
                 −2.745783 
                 −2.8018444 
               
               
                   
                   
                   
                 MMTV 
               
               
                   
                   
                   
                 integration 
               
               
                   
                   
                   
                 site 9A 
               
               
                 Bcam 
                 0.035928585 
                 ENSMUSG00000002980 
                 basal cell 
                 −2.8018444 
                 −5.5476274 
                 −2.745783 
                 −2.8018444 
               
               
                   
                   
                   
                 adhesion 
               
               
                   
                   
                   
                 molecule 
               
               
                 Emp1 
                 0.042189736 
                 ENSMUSG00000030208 
                 epithelial 
                 −2.7941766 
                 3.9081564 
                 6.702333 
                 −2.7941766 
               
               
                   
                   
                   
                 membrane 
               
               
                   
                   
                   
                 protein 1 
               
               
                 Parp16 
                 0.04001856 
                 ENSMUSG00000032392 
                 poly (ADP- 
                 −2.7347302 
                 −0.9361927 
                 1.7985375 
                 −2.7347302 
               
               
                   
                   
                   
                 ribose) 
               
               
                   
                   
                   
                 polymerase 
               
               
                   
                   
                   
                 family, 
               
               
                   
                   
                   
                 member 16 
               
               
                 Clcn7 
                 0.03428333 
                 ENSMUSG00000036636 
                 chloride 
                 −2.7234893 
                 5.0524917 
                 7.775981 
                 −2.7234893 
               
               
                   
                   
                   
                 channel 7 
               
               
                 Eno2 
                 0.03678912 
                 ENSMUSG00000004267 
                 enolase 2, 
                 −2.7158498 
                 1.080109 
                 3.7959588 
                 −2.7158498 
               
               
                   
                   
                   
                 gamma 
               
               
                   
                   
                   
                 neuronal 
               
               
                 Cbr3 
                 0.019589162 
                 ENSMUSG00000022947 
                 carbonyl 
                 −2.6822627 
                 −0.9361927 
                 1.74607 
                 −2.6822627 
               
               
                   
                   
                   
                 reductase 3 
               
               
                 Kdr 
                 9.9922E−09 
                 ENSMUSG00000062960 
                 kinase insert 
                 −2.6498416 
                 −5.3956246 
                 −2.745783 
                 −2.6498416 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 receptor 
               
               
                 Crip2 
                 0.031184219 
                 ENSMUSG00000006356 
                 cysteine rich 
                 −2.6498416 
                 −5.3956246 
                 −2.745783 
                 −2.6498416 
               
               
                   
                   
                   
                 protein 2 
               
               
                 Adcy5 
                 0.032074198 
                 ENSMUSG00000022840 
                 adenylate 
                 −2.6498416 
                 −5.3956246 
                 −2.745783 
                 −2.6498416 
               
               
                   
                   
                   
                 cyclase 5 
               
               
                 Tnfrsf25 
                 0.037834987 
                 ENSMUSG00000024793 
                 tumor 
                 −2.6498416 
                 −5.3956246 
                 −2.745783 
                 −2.6498416 
               
               
                   
                   
                   
                 necrosis 
               
               
                   
                   
                   
                 factor 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 superfamily, 
               
               
                   
                   
                   
                 member 25 
               
               
                 Nacc2 
                 1.90741E−05 
                 ENSMUSG00000026932 
                 nucleus 
                 −2.6016853 
                 0.64876974 
                 3.250455 
                 −2.6016853 
               
               
                   
                   
                   
                 accumbens 
               
               
                   
                   
                   
                 associated 2, 
               
               
                   
                   
                   
                 BEN and BTB 
               
               
                   
                   
                   
                 (POZ) domain 
               
               
                   
                   
                   
                 containing 
               
               
                 Vwf 
                 0.007897177 
                 ENSMUSG00000001930 
                 Von 
                 −2.6009319 
                 −3.0736964 
                 −0.4727645 
                 −2.6009319 
               
               
                   
                   
                   
                 Willebrand 
               
               
                   
                   
                   
                 factor 
               
               
                   
                   
                   
                 homolog 
               
               
                 Npl 
                 0.03968443 
                 ENSMUSG00000042684 
                 N- 
                 −2.5766314 
                 0.6043756 
                 3.181007 
                 −2.5766314 
               
               
                   
                   
                   
                 acetylneuraminate 
               
               
                   
                   
                   
                 pyruvate 
               
               
                   
                   
                   
                 lyase 
               
               
                 Tmprss11bnl 
                 0.006505034 
                 ENSMUSG00000035861 
                 transmembrane 
                 −2.53881 
                 −5.5476274 
                 −3.0088174 
                 −2.53881 
               
               
                   
                   
                   
                 protease, 
               
               
                   
                   
                   
                 serine 11b N 
               
               
                   
                   
                   
                 terminal like 
               
               
                 Gfi1b 
                 0.006821152 
                 ENSMUSG00000026815 
                 growth factor 
                 −2.53881 
                 −5.5476274 
                 −3.0088174 
                 −2.53881 
               
               
                   
                   
                   
                 independent 
               
               
                   
                   
                   
                 1B 
               
               
                 Gm9222 
                 0.024540374 
                 ENSMUSG00000091094 
                 predicted 
                 −2.53881 
                 −5.5476274 
                 −3.0088174 
                 −2.53881 
               
               
                   
                   
                   
                 gene 9222 
               
               
                 Scn5a 
                 0.043510694 
                 ENSMUSG00000032511 
                 sodium 
                 −2.53881 
                 −5.5476274 
                 −3.0088174 
                 −2.53881 
               
               
                   
                   
                   
                 channel, 
               
               
                   
                   
                   
                 voltage- 
               
               
                   
                   
                   
                 gated, type V, 
               
               
                   
                   
                   
                 alpha 
               
               
                 Celf6 
                 0.04390951 
                 ENSMUSG00000032297 
                 CUGBP, Elav- 
                 −2.53881 
                 −5.5476274 
                 −3.0088174 
                 −2.53881 
               
               
                   
                   
                   
                 like family 
               
               
                   
                   
                   
                 member 6 
               
               
                 Gm6507 
                 0.045192987 
                 ENSMUSG00000090013 
                 predicted 
                 −2.53881 
                 −5.5476274 
                 −3.0088174 
                 −2.53881 
               
               
                   
                   
                   
                 gene 6507 
               
               
                 Tm7sf4 
                 0.03066966 
                 ENSMUSG00000022303 
                 transmembrane 7 
                 −2.538506 
                 4.3441563 
                 6.8826623 
                 −2.538506 
               
               
                   
                   
                   
                 superfamily 
               
               
                   
                   
                   
                 member 4 
               
               
                 Zbtb42 
                 0.004560709 
                 ENSMUSG00000037638 
                 zinc finger 
                 −2.5282794 
                 −0.3512302 
                 2.1770492 
                 −2.5282794 
               
               
                   
                   
                   
                 and BTB 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 42 
               
               
                 Oprl1 
                 0.04202406 
                 ENSMUSG00000027584 
                 opioid 
                 −2.5243107 
                 −4.3956246 
                 −1.8713139 
                 −2.5243107 
               
               
                   
                   
                   
                 receptor-like 1 
               
               
                 Smpd1 
                 0.040762037 
                 ENSMUSG00000037049 
                 sphingomyelin 
                 −2.4983536 
                 2.8851464 
                 5.3835 
                 −2.4983536 
               
               
                   
                   
                   
                 phosphodiesterase 
               
               
                   
                   
                   
                 1, acid 
               
               
                   
                   
                   
                 lysosomal 
               
               
                 Copz2 
                 0.04132218 
                 ENSMUSG00000018672 
                 coatomer 
                 −2.4799163 
                 −3.8106618 
                 −1.3307455 
                 −2.4799163 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 complex, 
               
               
                   
                   
                   
                 subunit zeta 2 
               
               
                 Rab13 
                 0.014564358 
                 ENSMUSG00000027935 
                 RAB13, 
                 −2.4751628 
                 −1.1476969 
                 1.3274659 
                 −2.4751628 
               
               
                   
                   
                   
                 member RAS 
               
               
                   
                   
                   
                 oncogene 
               
               
                   
                   
                   
                 family 
               
               
                 Ltbp3 
                 1.11691E−09 
                 ENSMUSG00000024940 
                 latent 
                 −2.4571964 
                 −3.3956244 
                 −0.938428 
                 −2.4571964 
               
               
                   
                   
                   
                 transforming 
               
               
                   
                   
                   
                 growth factor 
               
               
                   
                   
                   
                 beta binding 
               
               
                   
                   
                   
                 protein 3 
               
               
                 Traf5 
                 0.005175546 
                 ENSMUSG00000026637 
                 TNF receptor- 
                 −2.4035177 
                 1.2908763 
                 3.694394 
                 −2.4035177 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 factor 5 
               
               
                 Rasgrp1 
                 2.63666E−09 
                 ENSMUSG00000027347 
                 RAS guanyl 
                 −2.3868072 
                 −5.3956246 
                 −3.0088174 
                 −2.3868072 
               
               
                   
                   
                   
                 releasing 
               
               
                   
                   
                   
                 protein 1 
               
               
                 Cyp3a41b 
                 0.007969925 
                 ENSMUSG00000075552 
                 cytochrome 
                 −2.3868072 
                 −5.3956246 
                 −3.0088174 
                 −2.3868072 
               
               
                   
                   
                   
                 P450, family 
               
               
                   
                   
                   
                 3, subfamily 
               
               
                   
                   
                   
                 a, 
               
               
                   
                   
                   
                 polypeptide 
               
               
                   
                   
                   
                 41B 
               
               
                 H2-M10.4 
                 0.008056933 
                 ENSMUSG00000048231 
                 histocompatibility 
                 −2.3868072 
                 −5.3956246 
                 −3.0088174 
                 −2.3868072 
               
               
                   
                   
                   
                 2, M 
               
               
                   
                   
                   
                 region locus 
               
               
                   
                   
                   
                 10.4 
               
               
                 Brsk1 
                 0.013945078 
                 ENSMUSG00000035390 
                 BR 
                 −2.3868072 
                 −5.3956246 
                 −3.0088174 
                 −2.3868072 
               
               
                   
                   
                   
                 serine/threonine 
               
               
                   
                   
                   
                 kinase 1 
               
               
                 Comp 
                 0.019483332 
                 ENSMUSG00000031849 
                 cartilage 
                 −2.3868072 
                 −5.3956246 
                 −3.0088174 
                 −2.3868072 
               
               
                   
                   
                   
                 oligomeric 
               
               
                   
                   
                   
                 matrix 
               
               
                   
                   
                   
                 protein 
               
               
                 Trp53i11 
                 1.85071E−07 
                 ENSMUSG00000068735 
                 transformation 
                 −2.3868071 
                 −3.0736964 
                 −0.6868893 
                 −2.3868071 
               
               
                   
                   
                   
                 related 
               
               
                   
                   
                   
                 protein 53 
               
               
                   
                   
                   
                 inducible 
               
               
                   
                   
                   
                 protein 11 
               
               
                 Gm17292 
                 0.026323678 
                 ENSMUSG00000091500 
                 predicted 
                 −2.3868071 
                 −3.0736964 
                 −0.6868893 
                 −2.3868071 
               
               
                   
                   
                   
                 gene, 17292 
               
               
                 Tmem92- 
                 0.012284395 
                 ENSMUSG00000075610 
                 transmembrane 
                 −2.3603347 
                 −1.9361928 
                 0.42414194 
                 −2.3603347 
               
               
                 ps 
                   
                   
                 protein 92, 
               
               
                   
                   
                   
                 pseudogene 
               
               
                 Prnp 
                 0.028792284 
                 ENSMUSG00000079037 
                 prion protein 
                 −2.3583783 
                 0.9619277 
                 3.320306 
                 −2.3583783 
               
               
                 Nos3 
                 0.029377611 
                 ENSMUSG00000028978 
                 nitric oxide 
                 −2.3279133 
                 −3.0736964 
                 −0.7457831 
                 −2.3279133 
               
               
                   
                   
                   
                 synthase 3, 
               
               
                   
                   
                   
                 endothelial 
               
               
                   
                   
                   
                 cell 
               
               
                 Kifc3 
                 0.02880698 
                 ENSMUSG00000031788 
                 kinesin family 
                 −2.3243729 
                 2.5987291 
                 4.923102 
                 −2.3243729 
               
               
                   
                   
                   
                 member C3 
               
               
                 D930049A15Rik 
                 0.017146215 
                 ENSMUSG00000087535 
                 RIKEN cDNA 
                 −2.3058869 
                 −1.9361928 
                 0.3696941 
                 −2.3058869 
               
               
                   
                   
                   
                 D930049A15 
               
               
                   
                   
                   
                 gene 
               
               
                 Dnajb13 
                 0.04825035 
                 ENSMUSG00000030708 
                 DnaJ (Hsp40) 
                 −2.2872711 
                 −3.8106618 
                 −1.5233907 
                 −2.2872711 
               
               
                   
                   
                   
                 related, 
               
               
                   
                   
                   
                 subfamily B, 
               
               
                   
                   
                   
                 member 13 
               
               
                 Ppargc1b 
                 0.047570087 
                 ENSMUSG00000033871 
                 peroxisome 
                 −2.2467025 
                 2.9352925 
                 5.181995 
                 −2.2467025 
               
               
                   
                   
                   
                 proliferative 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 receptor, 
               
               
                   
                   
                   
                 gamma, 
               
               
                   
                   
                   
                 coactivator 1 
               
               
                   
                   
                   
                 beta 
               
               
                 Zan 
                 0.046040762 
                 ENSMUSG00000079173 
                 zonadhesin 
                 −2.2348037 
                 −2.8106618 
                 −0.5758581 
                 −2.2348037 
               
               
                 Trpv4 
                 2.0579E−08 
                 ENSMUSG00000014158 
                 transient 
                 −2.2168817 
                 −5.5476274 
                 −3.3307457 
                 −2.2168817 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 potential 
               
               
                   
                   
                   
                 cation 
               
               
                   
                   
                   
                 channel, 
               
               
                   
                   
                   
                 subfamily V, 
               
               
                   
                   
                   
                 member 4 
               
               
                 Gm5878 
                 5.70138E−08 
                 ENSMUSG00000072952 
                 predicted 
                 −2.2168817 
                 −5.5476274 
                 −3.3307457 
                 −2.2168817 
               
               
                   
                   
                   
                 gene 5878 
               
               
                 Morn3 
                 0.01710776 
                 ENSMUSG00000029477 
                 MORN repeat 
                 −2.2168817 
                 −5.5476274 
                 −3.3307457 
                 −2.2168817 
               
               
                   
                   
                   
                 containing 3 
               
               
                 Ccdc136 
                 0.017162325 
                 ENSMUSG00000029769 
                 coiled-coil 
                 −2.2168817 
                 −5.5476274 
                 −3.3307457 
                 −2.2168817 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 136 
               
               
                 Pmel 
                 0.0373233 
                 ENSMUSG00000025359 
                 premelanosome 
                 −2.2168817 
                 −5.5476274 
                 −3.3307457 
                 −2.2168817 
               
               
                   
                   
                   
                 protein 
               
               
                 Exoc3l2 
                 0.03821163 
                 ENSMUSG00000011263 
                 exocyst 
                 −2.2168817 
                 −5.5476274 
                 −3.3307457 
                 −2.2168817 
               
               
                   
                   
                   
                 complex 
               
               
                   
                   
                   
                 component 3- 
               
               
                   
                   
                   
                 like 2 
               
               
                 Ctla4 
                 0.04272519 
                 ENSMUSG00000026011 
                 cytotoxic T- 
                 −2.2168817 
                 −5.5476274 
                 −3.3307457 
                 −2.2168817 
               
               
                   
                   
                   
                 lymphocyte- 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 protein 4 
               
               
                 Eltd1 
                 0.044563495 
                 ENSMUSG00000039167 
                 EGF, 
                 −2.2168817 
                 −5.5476274 
                 −3.3307457 
                 −2.2168817 
               
               
                   
                   
                   
                 latrophilin 
               
               
                   
                   
                   
                 seven 
               
               
                   
                   
                   
                 transmembrane 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 1 
               
               
                 Agap1 
                 0.006535044 
                 ENSMUSG00000055013 
                 ArfGAP with 
                 −2.2064753 
                 2.5112662 
                 4.7177415 
                 −2.2064753 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                   
                   
                 domain, 
               
               
                   
                   
                   
                 ankyrin 
               
               
                   
                   
                   
                 repeat and 
               
               
                   
                   
                   
                 PH domain 1 
               
               
                 Gm16938 
                 0.016329387 
                 ENSMUSG00000086325 
                 predicted 
                 −2.2023824 
                 −3.0736964 
                 −0.871314 
                 −2.2023824 
               
               
                   
                   
                   
                 gene, 16938 
               
               
                 BC043934 
                 0.016358571 
                 ENSMUSG00000056418 
                 cDNA 
                 −2.1803559 
                 −2.8106618 
                 −0.6303059 
                 −2.1803559 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 BC043934 
               
               
                 Atp6v1g1 
                 0.03608559 
                 ENSMUSG00000039105 
                 ATPase, H+ 
                 −2.1788064 
                 5.2264276 
                 7.405234 
                 −2.1788064 
               
               
                   
                   
                   
                 transporting, 
               
               
                   
                   
                   
                 lysosomal V1 
               
               
                   
                   
                   
                 subunit G1 
               
               
                 Aebp1 
                 1.28779E−07 
                 ENSMUSG00000020473 
                 AE binding 
                 −2.1523415 
                 −1.3956243 
                 0.7567172 
                 −2.1523415 
               
               
                   
                   
                   
                 protein 1 
               
               
                 Rgs10 
                 2.5485E−06 
                 ENSMUSG00000030844 
                 regulator of 
                 −2.1228371 
                 3.7207193 
                 5.8435564 
                 −2.1228371 
               
               
                   
                   
                   
                 G-protein 
               
               
                   
                   
                   
                 signalling 10 
               
               
                 Hist1h2be 
                 0.011067117 
                 ENSMUSG00000047246 
                 histone 
                 −2.1207322 
                 −1.1476969 
                 0.9730353 
                 −2.1207322 
               
               
                   
                   
                   
                 cluster 1, 
               
               
                   
                   
                   
                 H2be 
               
               
                 Bcar1 
                 0.005886043 
                 ENSMUSG00000031955 
                 breast cancer 
                 −2.1139732 
                 0.6267435 
                 2.7407167 
                 −2.1139732 
               
               
                   
                   
                   
                 anti-estrogen 
               
               
                   
                   
                   
                 resistance 1 
               
               
                 2310035K24Rik 
                 0.016051397 
                 ENSMUSG00000068264 
                 RIKEN cDNA 
                 −2.0865737 
                 1.9706978 
                 4.0572715 
                 −2.0865737 
               
               
                   
                   
                   
                 2310035K24 
               
               
                   
                   
                   
                 gene 
               
               
                 Spata9 
                 8.47829E−07 
                 ENSMUSG00000021590 
                 spermatogenesis 
                 −2.0648791 
                 −4.3956246 
                 −2.3307455 
                 −2.0648791 
               
               
                   
                   
                   
                 associated 9 
               
               
                 Cdh24 
                 0.003821577 
                 ENSMUSG00000059674 
                 cadherin-like 
                 −2.0648791 
                 −4.3956246 
                 −2.3307455 
                 −2.0648791 
               
               
                   
                   
                   
                 24 
               
               
                 Ccr4 
                 2.54713E−07 
                 ENSMUSG00000047898 
                 chemokine 
                 −2.0648789 
                 −5.3956246 
                 −3.3307457 
                 −2.0648789 
               
               
                   
                   
                   
                 (C-C motif) 
               
               
                   
                   
                   
                 receptor 4 
               
               
                 Trim15 
                 5.39696E−05 
                 ENSMUSG00000050747 
                 tripartite 
                 −2.0648789 
                 −5.3956246 
                 −3.3307457 
                 −2.0648789 
               
               
                   
                   
                   
                 motif- 
               
               
                   
                   
                   
                 containing 15 
               
               
                 Cntn2 
                 0.003975537 
                 ENSMUSG00000053024 
                 contactin 2 
                 −2.0648789 
                 −5.3956246 
                 −3.3307457 
                 −2.0648789 
               
               
                 Pacsin3 
                 0.004444425 
                 ENSMUSG00000027257 
                 protein 
                 −2.0648789 
                 −5.3956246 
                 −3.3307457 
                 −2.0648789 
               
               
                   
                   
                   
                 kinase C and 
               
               
                   
                   
                   
                 casein kinase 
               
               
                   
                   
                   
                 substrate in 
               
               
                   
                   
                   
                 neurons 3 
               
               
                 Ptch2 
                 0.004492317 
                 ENSMUSG00000028681 
                 patched 
                 −2.0648789 
                 −5.3956246 
                 −3.3307457 
                 −2.0648789 
               
               
                   
                   
                   
                 homolog 2 
               
               
                 Gm3086 
                 0.004751403 
                 ENSMUSG00000079076 
                 predicted 
                 −2.0648789 
                 −5.3956246 
                 −3.3307457 
                 −2.0648789 
               
               
                   
                   
                   
                 gene 3086 
               
               
                 Gm13520 
                 0.017877512 
                 ENSMUSG00000052403 
                 predicted 
                 −2.0648789 
                 −5.3956246 
                 −3.3307457 
                 −2.0648789 
               
               
                   
                   
                   
                 gene 13520 
               
               
                 4831440E17Rik 
                 0.047423657 
                 ENSMUSG00000091303 
                 RIKEN cDNA 
                 −2.0648789 
                 −5.3956246 
                 −3.3307457 
                 −2.0648789 
               
               
                   
                   
                   
                 4831440E17 
               
               
                   
                   
                   
                 gene 
               
               
                 Olr1 
                 0.02391179 
                 ENSMUSG00000030162 
                 oxidized low 
                 −2.0648788 
                 −1.5882694 
                 0.47660938 
                 −2.0648788 
               
               
                   
                   
                   
                 density 
               
               
                   
                   
                   
                 lipoprotein 
               
               
                   
                   
                   
                 (lectin-like) 
               
               
                   
                   
                   
                 receptor 1 
               
               
                 Gpr68 
                 0.014538036 
                 ENSMUSG00000047415 
                 G protein- 
                 −2.0587823 
                 3.3013432 
                 5.3601255 
                 −2.0587823 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 receptor 68 
               
               
                 Speg 
                 0.016736077 
                 ENSMUSG00000026207 
                 SPEG 
                 −2.046822 
                 2.2554274 
                 4.3022494 
                 −2.046822 
               
               
                   
                   
                   
                 complex 
               
               
                   
                   
                   
                 locus 
               
               
                 Rab11fip5 
                 0.002548879 
                 ENSMUSG00000051343 
                 RAB11 family 
                 −1.9835787 
                 1.7942002 
                 3.7777789 
                 −1.9835787 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 protein 5 
               
               
                   
                   
                   
                 (class I) 
               
               
                 Kidins220 
                 0.019567724 
                 ENSMUSG00000036333 
                 kinase D- 
                 −1.939535 
                 6.379986 
                 8.319521 
                 −1.939535 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 substrate 220 
               
               
                 Atp6v1e1 
                 0.004245304 
                 ENSMUSG00000019210 
                 ATPase, H+ 
                 −1.9293203 
                 4.4885464 
                 6.4178667 
                 −1.9293203 
               
               
                   
                   
                   
                 transporting, 
               
               
                   
                   
                   
                 lysosomal V1 
               
               
                   
                   
                   
                 subunit E1 
               
               
                 Pvrl2 
                 8.34206E−07 
                 ENSMUSG00000062300 
                 poliovirus 
                 −1.9279968 
                 0.4623566 
                 2.3903534 
                 −1.9279968 
               
               
                   
                   
                   
                 receptor- 
               
               
                   
                   
                   
                 related 2 
               
               
                 Tspan17 
                 1.0474E−07 
                 ENSMUSG00000025875 
                 tetraspanin 
                 −1.9204887 
                 0.5816556 
                 2.5021443 
                 −1.9204887 
               
               
                   
                   
                   
                 17 
               
               
                 Gale 
                 0.019762464 
                 ENSMUSG00000028671 
                 galactose-4- 
                 −1.8952713 
                 1.7541227 
                 3.649394 
                 −1.8952713 
               
               
                   
                   
                   
                 epimerase, 
               
               
                   
                   
                   
                 UDP 
               
               
                 Rcan1 
                 0.01904115 
                 ENSMUSG00000022951 
                 regulator of 
                 −1.874314 
                 4.818695 
                 6.693009 
                 −1.874314 
               
               
                   
                   
                   
                 calcineurin 1 
               
               
                 Gm11973 
                 2.37392E−07 
                 ENSMUSG00000086839 
                 predicted 
                 −1.8722338 
                 −0.8106618 
                 1.061572 
                 −1.8722338 
               
               
                   
                   
                   
                 gene 11973 
               
               
                 Jag1 
                 7.22295E−06 
                 ENSMUSG00000027276 
                 jagged 1 
                 −1.8641286 
                 4.084156 
                 5.9482846 
                 −1.8641286 
               
               
                 Pkn3 
                 0.008641912 
                 ENSMUSG00000026785 
                 protein 
                 −1.861691 
                 3.7566605 
                 5.6183515 
                 −1.861691 
               
               
                   
                   
                   
                 kinase N3 
               
               
                 Gpr137b- 
                 0.037627038 
                 ENSMUSG00000075118 
                 G protein- 
                 −1.8487921 
                 5.7122464 
                 7.5610385 
                 −1.8487921 
               
               
                 ps 
                   
                   
                 coupled 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 137B, 
               
               
                   
                   
                   
                 pseudogene 
               
               
                 Gpr137b 
                 0.000425558 
                 ENSMUSG00000021306 
                 G protein- 
                 −1.8473807 
                 6.3339963 
                 8.181377 
                 −1.8473807 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 137B 
               
               
                 Fastk 
                 0.025559984 
                 ENSMUSG00000028959 
                 Fas-activated 
                 −1.8316917 
                 4.5629287 
                 6.3946204 
                 −1.8316917 
               
               
                   
                   
                   
                 serine/threonine 
               
               
                   
                   
                   
                 kinase 
               
               
                 Fhod1 
                 0.021275658 
                 ENSMUSG00000014778 
                 formin 
                 −1.83153 
                 3.174231 
                 5.005761 
                 −1.83153 
               
               
                   
                   
                   
                 homology 2 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 1 
               
               
                 Klf10 
                 0.025064955 
                 ENSMUSG00000037465 
                 Kruppel-like 
                 −1.8288834 
                 2.3987916 
                 4.227675 
                 −1.8288834 
               
               
                   
                   
                   
                 factor 10 
               
               
                 Gm16170 
                 0.025048712 
                 ENSMUSG00000086245 
                 predicted 
                 −1.8018444 
                 −3.8106618 
                 −2.0088174 
                 −1.8018444 
               
               
                   
                   
                   
                 gene 16170 
               
               
                 Nrarp 
                 6.95089E−07 
                 ENSMUSG00000078202 
                 Notch- 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 regulated 
               
               
                   
                   
                   
                 ankyrin 
               
               
                   
                   
                   
                 repeat 
               
               
                   
                   
                   
                 protein 
               
               
                 Rab19 
                 1.2671E−06 
                 ENSMUSG00000029923 
                 RAB19, 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 member RAS 
               
               
                   
                   
                   
                 oncogene 
               
               
                   
                   
                   
                 family 
               
               
                 Hapln3 
                 1.68935E−06 
                 ENSMUSG00000030606 
                 hyaluronan 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 and 
               
               
                   
                   
                   
                 proteoglycan 
               
               
                   
                   
                   
                 link protein 3 
               
               
                 Ccdc80 
                 2.68412E−06 
                 ENSMUSG00000022665 
                 coiled-coil 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 80 
               
               
                 Gm4841 
                 3.87708E−06 
                 ENSMUSG00000068606 
                 predicted 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 gene 4841 
               
               
                 4930412F09Rik 
                 4.95275E−06 
                 ENSMUSG00000085321 
                 RIKEN cDNA 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 4930412F09 
               
               
                   
                   
                   
                 gene 
               
               
                 Gm7694 
                 2.55599E−05 
                 ENSMUSG00000079188 
                 predicted 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 gene 7694 
               
               
                 Mesp2 
                 0.000146221 
                 ENSMUSG00000030543 
                 mesoderm 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 posterior 2 
               
               
                 Rnf152 
                 0.000155408 
                 ENSMUSG00000047496 
                 ring finger 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 protein 152 
               
               
                 Gad1-ps 
                 0.000243773 
                 ENSMUSG00000090665 
                 glutamic acid 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 decarboxylase 
               
               
                   
                   
                   
                 1, 
               
               
                   
                   
                   
                 pseudogene 
               
               
                 Syngr3 
                 0.000536011 
                 ENSMUSG00000007021 
                 synaptogyrin 3 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                 Lrrc69 
                 0.000857033 
                 ENSMUSG00000023151 
                 leucine rich 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 repeat 
               
               
                   
                   
                   
                 containing 69 
               
               
                 Zfp352 
                 0.000882844 
                 ENSMUSG00000070902 
                 zinc finger 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 protein 352 
               
               
                 Mapk8ip1 
                 0.001025129 
                 ENSMUSG00000027223 
                 mitogen- 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 kinase 8 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 protein 1 
               
               
                 Cplx2 
                 0.001481371 
                 ENSMUSG00000025867 
                 complexin 2 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                 2310005G13Rik 
                 0.005757555 
                 ENSMUSG00000046748 
                 RIKEN cDNA 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 2310005G13 
               
               
                   
                   
                   
                 gene 
               
               
                 Ndst3 
                 0.00595649 
                 ENSMUSG00000027977 
                 N- 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 deacetylase/ 
               
               
                   
                   
                   
                 N- 
               
               
                   
                   
                   
                 sulfotransferase 
               
               
                   
                   
                   
                 (heparan 
               
               
                   
                   
                   
                 glucosaminyl) 3 
               
               
                 Cdhr2 
                 0.008793266 
                 ENSMUSG00000034918 
                 cadherin- 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 related family 
               
               
                   
                   
                   
                 member 2 
               
               
                 Tac4 
                 0.009837943 
                 ENSMUSG00000020872 
                 tachykinin 4 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                 Nexn 
                 0.011523547 
                 ENSMUSG00000039103 
                 nexilin 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                 Usp17l5 
                 0.013230624 
                 ENSMUSG00000058976 
                 ubiquitin 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 specific 
               
               
                   
                   
                   
                 peptidase 17- 
               
               
                   
                   
                   
                 like 5 
               
               
                 9430020K01Rik 
                 0.028962463 
                 ENSMUSG00000033960 
                 RIKEN cDNA 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 9430020K01 
               
               
                   
                   
                   
                 gene 
               
               
                 Rian 
                 0.032669194 
                 ENSMUSG00000091793 
                 RNA 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 imprinted 
               
               
                   
                   
                   
                 and 
               
               
                   
                   
                   
                 accumulated 
               
               
                   
                   
                   
                 in nucleus 
               
               
                 Fras1 
                 0.03300434 
                 ENSMUSG00000034687 
                 Fraser 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 syndrome 1 
               
               
                   
                   
                   
                 homolog 
               
               
                   
                   
                   
                 (human) 
               
               
                 Rasgrp2 
                 0.038632754 
                 ENSMUSG00000032946 
                 RAS, guanyl 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 releasing 
               
               
                   
                   
                   
                 protein 2 
               
               
                 Gcnt2 
                 0.042023577 
                 ENSMUSG00000021360 
                 glucosaminyl 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 (N-acetyl) 
               
               
                   
                   
                   
                 transferase 2, 
               
               
                   
                   
                   
                 I-branching 
               
               
                   
                   
                   
                 enzyme 
               
               
                 Pcdhb19 
                 0.042246673 
                 ENSMUSG00000043313 
                 protocadherin 
                 −1.8018444 
                 −5.5476274 
                 −3.745783 
                 −1.8018444 
               
               
                   
                   
                   
                 beta 19 
               
               
                 Cpt1c 
                 1.00434E−05 
                 ENSMUSG00000007783 
                 carnitine 
                 −1.7653185 
                 −3.3956244 
                 −1.6303059 
                 −1.7653185 
               
               
                   
                   
                   
                 palmitoyltransferase 
               
               
                   
                   
                   
                 1c 
               
               
                 Tcirg1 
                 2.59394E−05 
                 ENSMUSG00000001750 
                 T-cell, 
                 −1.759994 
                 7.245976 
                 9.00597 
                 −1.759994 
               
               
                   
                   
                   
                 immune 
               
               
                   
                   
                   
                 regulator 1, 
               
               
                   
                   
                   
                 ATPase, H+ 
               
               
                   
                   
                   
                 transporting, 
               
               
                   
                   
                   
                 lysosomal V0 
               
               
                   
                   
                   
                 protein A3 
               
               
                 Dguok 
                 0.030540211 
                 ENSMUSG00000014554 
                 deoxyguanosine 
                 −1.7519393 
                 0.24823192 
                 2.0001712 
                 −1.7519393 
               
               
                   
                   
                   
                 kinase 
               
               
                 Rnasek 
                 0.03223572 
                 ENSMUSG00000040904 
                 ribonuclease, 
                 −1.7483242 
                 2.9923928 
                 4.740717 
                 −1.7483242 
               
               
                   
                   
                   
                 RNase K 
               
               
                 Tmem170 
                 0.004925352 
                 ENSMUSG00000031953 
                 transmembrane 
                 −1.7414716 
                 0.53511304 
                 2.2765846 
                 −1.7414716 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 170 
               
               
                 Cdkl4 
                 2.17175E−05 
                 ENSMUSG00000033966 
                 cyclin- 
                 −1.7332573 
                 −0.5882695 
                 1.1449878 
                 −1.7332573 
               
               
                   
                   
                   
                 dependent 
               
               
                   
                   
                   
                 kinase-like 4 
               
               
                 AA386476 
                 0.00223168 
                 ENSMUSG00000074357 
                 expressed 
                 −1.7169555 
                 −2.5882695 
                 −0.871314 
                 −1.7169555 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 AA386476 
               
               
                 Efemp2 
                 4.01625E−05 
                 ENSMUSG00000024909 
                 epidermal 
                 −1.7053364 
                 −1.3081615 
                 0.39717492 
                 −1.7053364 
               
               
                   
                   
                   
                 growth 
               
               
                   
                   
                   
                 factor- 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 fibulin-like 
               
               
                   
                   
                   
                 extracellular 
               
               
                   
                   
                   
                 matrix 
               
               
                   
                   
                   
                 protein 2 
               
               
                 Atox1 
                 0.00219727 
                 ENSMUSG00000018585 
                 ATX1 
                 −1.6888047 
                 2.2978625 
                 3.9866672 
                 −1.6888047 
               
               
                   
                   
                   
                 (antioxidant 
               
               
                   
                   
                   
                 protein 1) 
               
               
                   
                   
                   
                 homolog 1 
               
               
                   
                   
                   
                 (yeast) 
               
               
                 Acot13 
                 0.03344103 
                 ENSMUSG00000006717 
                 acyl-CoA 
                 −1.655059 
                 1.1279377 
                 2.7829967 
                 −1.655059 
               
               
                   
                   
                   
                 thioesterase 
               
               
                   
                   
                   
                 13 
               
               
                 Zfand5 
                 0.041743267 
                 ENSMUSG00000024750 
                 zinc finger, 
                 −1.6533193 
                 5.2987337 
                 6.952053 
                 −1.6533193 
               
               
                   
                   
                   
                 AN1-type 
               
               
                   
                   
                   
                 domain 5 
               
               
                 Gng8 
                 6.13976E−05 
                 ENSMUSG00000063594 
                 guanine 
                 −1.6498416 
                 −5.3956246 
                 −3.745783 
                 −1.6498416 
               
               
                   
                   
                   
                 nucleotide 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein (G 
               
               
                   
                   
                   
                 protein), 
               
               
                   
                   
                   
                 gamma 8 
               
               
                 Ldb3 
                 0.000180388 
                 ENSMUSG00000021798 
                 LIM domain 
                 −1.6498416 
                 −5.3956246 
                 −3.745783 
                 −1.6498416 
               
               
                   
                   
                   
                 binding 3 
               
               
                 Tpm2 
                 0.000303012 
                 ENSMUSG00000028464 
                 tropomyosin 
                 −1.6498416 
                 −4.3956246 
                 −2.745783 
                 −1.6498416 
               
               
                   
                   
                   
                 2, beta 
               
               
                 Mamstr 
                 0.001821696 
                 ENSMUSG00000042918 
                 MEF2 
                 −1.6498416 
                 −5.3956246 
                 −3.745783 
                 −1.6498416 
               
               
                   
                   
                   
                 activating 
               
               
                   
                   
                   
                 motif and SAP 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 transcriptional 
               
               
                   
                   
                   
                 regulator 
               
               
                 0610009L18Rik 
                 0.020528933 
                 ENSMUSG00000043644 
                 RIKEN cDNA 
                 −1.6498416 
                 −5.3956246 
                 −3.745783 
                 −1.6498416 
               
               
                   
                   
                   
                 0610009L18 
               
               
                   
                   
                   
                 gene 
               
               
                 Wdr96 
                 0.032827605 
                 ENSMUSG00000044948 
                 WD repeat 
                 −1.6498416 
                 −5.3956246 
                 −3.745783 
                 −1.6498416 
               
               
                   
                   
                   
                 domain 96 
               
               
                 E030010A14Rik 
                 0.046596386 
                 ENSMUSG00000048572 
                 RIKEN cDNA 
                 −1.6498416 
                 −5.3956246 
                 −3.745783 
                 −1.6498416 
               
               
                   
                   
                   
                 E030010A14 
               
               
                   
                   
                   
                 gene 
               
               
                 Itih1 
                 0.048211228 
                 ENSMUSG00000006529 
                 inter-alpha 
                 −1.6498416 
                 −5.3956246 
                 −3.745783 
                 −1.6498416 
               
               
                   
                   
                   
                 trypsin 
               
               
                   
                   
                   
                 inhibitor, 
               
               
                   
                   
                   
                 heavy chain 1 
               
               
                 1600016N20Rik 
                 1.96971E−06 
                 ENSMUSG00000025500 
                 RIKEN cDNA 
                 −1.6498414 
                 −3.3956244 
                 −1.745783 
                 −1.6498414 
               
               
                   
                   
                   
                 1600016N20 
               
               
                   
                   
                   
                 gene 
               
               
                 AA543186 
                 0.036252256 
                 ENSMUSG00000091706 
                 expressed 
                 −1.6498413 
                 −3.0736964 
                 −1.4238551 
                 −1.6498413 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 AA543186 
               
               
                 Adc 
                 0.004476923 
                 ENSMUSG00000028789 
                 arginine 
                 −1.6296634 
                 −0.8106618 
                 0.8190016 
                 −1.6296634 
               
               
                   
                   
                   
                 decarboxylase 
               
               
                 Sh3bgrl3 
                 0.003731431 
                 ENSMUSG00000028843 
                 SH3 domain 
                 −1.6179714 
                 6.1131606 
                 7.731132 
                 −1.6179714 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 glutamic acid- 
               
               
                   
                   
                   
                 rich protein- 
               
               
                   
                   
                   
                 like 3 
               
               
                 B430212C06Rik 
                 0.014717348 
                 ENSMUSG00000046415 
                 RIKEN cDNA 
                 −1.6009319 
                 −2.0736964 
                 −0.4727645 
                 −1.6009319 
               
               
                   
                   
                   
                 B430212C06 
               
               
                   
                   
                   
                 gene 
               
               
                 Cblb 
                 0.000721993 
                 ENSMUSG00000022637 
                 Casitas B- 
                 −1.5841252 
                 2.6377988 
                 4.221924 
                 −1.5841252 
               
               
                   
                   
                   
                 lineage 
               
               
                   
                   
                   
                 lymphoma b 
               
               
                 A530083I20Rik 
                 0.000124989 
                 ENSMUSG00000086343 
                 RIKEN cDNA 
                 −1.5794521 
                 −2.5882695 
                 −1.0088174 
                 −1.5794521 
               
               
                   
                   
                   
                 A530083I20 
               
               
                   
                   
                   
                 gene 
               
               
                 Cyb561 
                 0.02012645 
                 ENSMUSG00000019590 
                 cytochrome 
                 −1.5761316 
                 1.0473192 
                 2.6234508 
                 −1.5761316 
               
               
                   
                   
                   
                 b-561 
               
               
                 Uqcr10 
                 0.034956805 
                 ENSMUSG00000059534 
                 ubiquinol- 
                 −1.5471251 
                 3.6239665 
                 5.1710916 
                 −1.5471251 
               
               
                   
                   
                   
                 cytochrome c 
               
               
                   
                   
                   
                 reductase, 
               
               
                   
                   
                   
                 complex III 
               
               
                   
                   
                   
                 subunit X 
               
               
                 Cbx8 
                 0.046324532 
                 ENSMUSG00000025578 
                 chromobox 
                 −1.5326578 
                 0.15896448 
                 1.6916223 
                 −1.5326578 
               
               
                   
                   
                   
                 homolog 8 
               
               
                   
                   
                   
                 ( Drosophila   
               
               
                   
                   
                   
                 Pc class) 
               
               
                 Comtd1 
                 0.000179086 
                 ENSMUSG00000021773 
                 catechol-O- 
                 −1.526407 
                 3.57016 
                 5.096567 
                 −1.526407 
               
               
                   
                   
                   
                 methyltransferase 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 1 
               
               
                 B430203G13Rik 
                 0.000268071 
                 ENSMUSG00000067356 
                 RIKEN cDNA 
                 −1.5243105 
                 −3.3956244 
                 −1.8713139 
                 −1.5243105 
               
               
                   
                   
                   
                 B430203G13 
               
               
                   
                   
                   
                 gene 
               
               
                 Tenc1 
                 0.00078725 
                 ENSMUSG00000037003 
                 tensin like C1 
                 −1.5243105 
                 −3.3956244 
                 −1.8713139 
                 −1.5243105 
               
               
                   
                   
                   
                 domain- 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 phosphatase 
               
               
                 Fam71f2 
                 0.04721271 
                 ENSMUSG00000079652 
                 family with 
                 −1.5243105 
                 −3.3956244 
                 −1.8713139 
                 −1.5243105 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 similarity 71, 
               
               
                   
                   
                   
                 member F2 
               
               
                 Gnas 
                 0.002411892 
                 ENSMUSG00000027523 
                 GNAS 
                 −1.5211316 
                 5.855266 
                 7.3763976 
                 −1.5211316 
               
               
                   
                   
                   
                 (guanine 
               
               
                   
                   
                   
                 nucleotide 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein, alpha 
               
               
                   
                   
                   
                 stimulating) 
               
               
                   
                   
                   
                 complex 
               
               
                   
                   
                   
                 locus 
               
               
                 Tsku 
                 1.447E−05 
                 ENSMUSG00000049580 
                 tsukushi 
                 −1.5165749 
                 −0.3081615 
                 1.2084134 
                 −1.5165749 
               
               
                 B3galt4 
                 2.46354E−05 
                 ENSMUSG00000067370 
                 UDP- 
                 −1.5096637 
                 −1.2256994 
                 0.28396425 
                 −1.5096637 
               
               
                   
                   
                   
                 Gal:betaGlcNAc 
               
               
                   
                   
                   
                 beta 1,3- 
               
               
                   
                   
                   
                 galactosyltransferase, 
               
               
                   
                   
                   
                 polypeptide 4 
               
               
                 Actg1 
                 6.26977E−05 
                 ENSMUSG00000062825 
                 actin, 
                 −1.504394 
                 8.558754 
                 10.063148 
                 −1.504394 
               
               
                   
                   
                   
                 gamma, 
               
               
                   
                   
                   
                 cytoplasmic 1 
               
               
                 Slc39a13 
                 0.042252257 
                 ENSMUSG00000002105 
                 solute carrier 
                 −1.5026059 
                 4.2978625 
                 5.8004684 
                 −1.5026059 
               
               
                   
                   
                   
                 family 39 
               
               
                   
                   
                   
                 (metal ion 
               
               
                   
                   
                   
                 transporter), 
               
               
                   
                   
                   
                 member 13 
               
               
                 Pde8b 
                 0.000171998 
                 ENSMUSG00000021684 
                 phosphodiesterase 
                 −1.4957519 
                 3.5321536 
                 5.0279055 
                 −1.4957519 
               
               
                   
                   
                   
                 8B 
               
               
                 Pla1a 
                 0.048690666 
                 ENSMUSG00000002847 
                 phospholipase 
                 −1.4945631 
                 0.2190855 
                 1.7136486 
                 −1.4945631 
               
               
                   
                   
                   
                 A1 member A 
               
               
                 Ihh 
                 0.000187296 
                 ENSMUSG00000006538 
                 Indian 
                 −1.4799163 
                 −3.8106618 
                 −2.3307455 
                 −1.4799163 
               
               
                   
                   
                   
                 hedgehog 
               
               
                 Bst1 
                 0.027398707 
                 ENSMUSG00000029082 
                 bone marrow 
                 −1.4799163 
                 1.9442257 
                 3.424142 
                 −1.4799163 
               
               
                   
                   
                   
                 stromal cell 
               
               
                   
                   
                   
                 antigen 1 
               
               
                 Pmepa1 
                 0.001784973 
                 ENSMUSG00000038400 
                 prostate 
                 −1.4649818 
                 3.0638072 
                 4.528789 
                 −1.4649818 
               
               
                   
                   
                   
                 transmembrane 
               
               
                   
                   
                   
                 protein, 
               
               
                   
                   
                   
                 androgen 
               
               
                   
                   
                   
                 induced 1 
               
               
                 Ostm1 
                 0.000209975 
                 ENSMUSG00000038280 
                 osteopetrosis 
                 −1.4622026 
                 4.755392 
                 6.2175946 
                 −1.4622026 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 transmembrane 
               
               
                   
                   
                   
                 protein 1 
               
               
                 Pnkd 
                 0.002613748 
                 ENSMUSG00000026179 
                 paroxysmal 
                 −1.453757 
                 1.9263037 
                 3.3800607 
                 −1.453757 
               
               
                   
                   
                   
                 nonkinesiogenic 
               
               
                   
                   
                   
                 dyskinesia 
               
               
                 Aldoc 
                 0.031371355 
                 ENSMUSG00000017390 
                 aldolase C, 
                 −1.4523878 
                 4.3742137 
                 5.8266015 
                 −1.4523878 
               
               
                   
                   
                   
                 fructose- 
               
               
                   
                   
                   
                 bisphosphate 
               
               
                 Gpr157 
                 0.002507451 
                 ENSMUSG00000047875 
                 G protein- 
                 −1.4509373 
                 1.0638072 
                 2.5147445 
                 −1.4509373 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 receptor 157 
               
               
                 Itm2c 
                 0.000136527 
                 ENSMUSG00000026223 
                 integral 
                 −1.4433904 
                 5.314321 
                 6.7577114 
                 −1.4433904 
               
               
                   
                   
                   
                 membrane 
               
               
                   
                   
                   
                 protein 2C 
               
               
                 Pld1 
                 0.001237733 
                 ENSMUSG00000027695 
                 phospholipase 
                 −1.4425491 
                 1.6487699 
                 3.091319 
                 −1.4425491 
               
               
                   
                   
                   
                 D1 
               
               
                 Sun2 
                 0.005151057 
                 ENSMUSG00000042524 
                 Sad1 and 
                 −1.4423764 
                 4.701091 
                 6.1434674 
                 −1.4423764 
               
               
                   
                   
                   
                 UNC84 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 2 
               
               
                 Cdon 
                 0.018776068 
                 ENSMUSG00000038119 
                 cell adhesion 
                 −1.4239599 
                 −0.8720624 
                 0.55189747 
                 −1.4239599 
               
               
                   
                   
                   
                 molecule- 
               
               
                   
                   
                   
                 related/down- 
               
               
                   
                   
                   
                 regulated by 
               
               
                   
                   
                   
                 oncogenes 
               
               
                 Cyp4f13 
                 0.000314138 
                 ENSMUSG00000024055 
                 cytochrome 
                 −1.4210226 
                 1.57016 
                 2.9911826 
                 −1.4210226 
               
               
                   
                   
                   
                 P450, family 
               
               
                   
                   
                   
                 4, subfamily f, 
               
               
                   
                   
                   
                 polypeptide 
               
               
                   
                   
                   
                 13 
               
               
                 Gcc1 
                 0.002457876 
                 ENSMUSG00000029708 
                 golgi coiled 
                 −1.4146862 
                 2.9619274 
                 4.3766136 
                 −1.4146862 
               
               
                   
                   
                   
                 coil 1 
               
               
                 Grhpr 
                 0.004643564 
                 ENSMUSG00000035637 
                 glyoxylate 
                 −1.4079125 
                 1.1742313 
                 2.5821438 
                 −1.4079125 
               
               
                   
                   
                   
                 reductase/hydroxypyruvate 
               
               
                   
                   
                   
                 reductase 
               
               
                 Traf6 
                 0.04253863 
                 ENSMUSG00000027164 
                 TNF receptor- 
                 −1.3917976 
                 4.262587 
                 5.6543846 
                 −1.3917976 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 factor 6 
               
               
                 Plcg1 
                 0.027477618 
                 ENSMUSG00000016933 
                 phospholipase 
                 −1.3875122 
                 3.2803328 
                 4.667845 
                 −1.3875122 
               
               
                   
                   
                   
                 C, gamma 1 
               
               
                 Gm711 
                 0.000219044 
                 ENSMUSG00000049897 
                 predicted 
                 −1.3868072 
                 −4.3956246 
                 −3.0088174 
                 −1.3868072 
               
               
                   
                   
                   
                 gene 711 
               
               
                 Gpr182 
                 0.001226294 
                 ENSMUSG00000058396 
                 G protein- 
                 −1.386807 
                 −3.3956244 
                 −2.0088174 
                 −1.386807 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 receptor 182 
               
               
                 D2hgdh 
                 0.006610859 
                 ENSMUSG00000073609 
                 D-2- 
                 −1.3820164 
                 2.1042216 
                 3.486238 
                 −1.3820164 
               
               
                   
                   
                   
                 hydroxyglutarate 
               
               
                   
                   
                   
                 dehydrogenase 
               
               
                 Tmem19 
                 0.001470068 
                 ENSMUSG00000069520 
                 transmembrane 
                 −1.3742473 
                 3.8874643 
                 5.2617116 
                 −1.3742473 
               
               
                   
                   
                   
                 protein 19 
               
               
                 Tmem120a 
                 0.018098773 
                 ENSMUSG00000039886 
                 transmembrane 
                 −1.3698108 
                 3.3987916 
                 4.7686024 
                 −1.3698108 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 120A 
               
               
                 Tssk6 
                 0.00016489 
                 ENSMUSG00000047654 
                 testis-specific 
                 −1.3576605 
                 −0.0736962 
                 1.2839643 
                 −1.3576605 
               
               
                   
                   
                   
                 serine kinase 6 
               
               
                 Camk1 
                 7.14941E−05 
                 ENSMUSG00000030272 
                 calcium/calmodulin- 
                 −1.351926 
                 3.342468 
                 4.694394 
                 −1.351926 
               
               
                   
                   
                   
                 dependent 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 kinase I 
               
               
                 Mitf 
                 0.001512894 
                 ENSMUSG00000035158 
                 microphthalmia- 
                 −1.350885 
                 4.788011 
                 6.138896 
                 −1.350885 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 transcription 
               
               
                   
                   
                   
                 factor 
               
               
                 Hspa1b 
                 0.000582485 
                 ENSMUSG00000090877 
                 heat shock 
                 −1.3323592 
                 −0.6407369 
                 0.69162226 
                 −1.3323592 
               
               
                   
                   
                   
                 protein 1B 
               
               
                 Hyal2 
                 0.04322722 
                 ENSMUSG00000010047 
                 hyalurono- 
                 −1.3124657 
                 3.4052758 
                 4.7177415 
                 −1.3124657 
               
               
                   
                   
                   
                 glucosaminidase 2 
               
               
                 Snapc5 
                 0.001169527 
                 ENSMUSG00000032398 
                 small nuclear 
                 −1.3058869 
                 −0.3512302 
                 0.95465666 
                 −1.3058869 
               
               
                   
                   
                   
                 RNA 
               
               
                   
                   
                   
                 activating 
               
               
                   
                   
                   
                 complex, 
               
               
                   
                   
                   
                 polypeptide 5 
               
               
                 Adcy9 
                 0.000661473 
                 ENSMUSG00000005580 
                 adenylate 
                 −1.3011768 
                 2.0719812 
                 3.373158 
                 −1.3011768 
               
               
                   
                   
                   
                 cyclase 9 
               
               
                 Sh3bgrl 
                 0.000909132 
                 ENSMUSG00000031246 
                 SH3-binding 
                 −1.2961377 
                 4.8391933 
                 6.135331 
                 −1.2961377 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 glutamic acid- 
               
               
                   
                   
                   
                 rich protein 
               
               
                   
                   
                   
                 like 
               
               
                 Trip10 
                 0.03646866 
                 ENSMUSG00000019487 
                 thyroid 
                 −1.2951012 
                 2.9035838 
                 4.198685 
                 −1.2951012 
               
               
                   
                   
                   
                 hormone 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 interactor 10 
               
               
                 Glis2 
                 0.000204305 
                 ENSMUSG00000014303 
                 GLIS family 
                 −1.2872714 
                 −2.2256994 
                 −0.938428 
                 −1.2872714 
               
               
                   
                   
                   
                 zinc finger 2 
               
               
                 4732465J04Rik 
                 0.000652129 
                 ENSMUSG00000071107 
                 RIKEN cDNA 
                 −1.287271 
                 −3.8106618 
                 −2.5233908 
                 −1.287271 
               
               
                   
                   
                   
                 4732465104 
               
               
                   
                   
                   
                 gene 
               
               
                 Dstn 
                 0.009541933 
                 ENSMUSG00000015932 
                 destrin 
                 −1.2852877 
                 6.1116743 
                 7.396962 
                 −1.2852877 
               
               
                 Bad 
                 0.03586843 
                 ENSMUSG00000024959 
                 BCL2- 
                 −1.2839432 
                 2.1435344 
                 3.4274776 
                 −1.2839432 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 agonist of cell 
               
               
                   
                   
                   
                 death 
               
               
                 Cbr1 
                 0.04490556 
                 ENSMUSG00000051483 
                 carbonyl 
                 −1.2796881 
                 1.3725599 
                 2.652248 
                 −1.2796881 
               
               
                   
                   
                   
                 reductase 1 
               
               
                 Cd180 
                 0.04057961 
                 ENSMUSG00000021624 
                 CD180 
                 −1.2769055 
                 5.7043805 
                 6.981286 
                 −1.2769055 
               
               
                   
                   
                   
                 antigen 
               
               
                 Kbtbd11 
                 0.016952015 
                 ENSMUSG00000055675 
                 kelch repeat 
                 −1.2746457 
                 6.516142 
                 7.7907877 
                 −1.2746457 
               
               
                   
                   
                   
                 and BTB 
               
               
                   
                   
                   
                 (POZ) domain 
               
               
                   
                   
                   
                 containing 11 
               
               
                 Rftn2 
                 0.000334329 
                 ENSMUSG00000025978 
                 raftlin family 
                 −1.2743322 
                 −1.3956243 
                 −0.1212921 
                 −1.2743322 
               
               
                   
                   
                   
                 member 2 
               
               
                 Bloc1s1 
                 0.005817233 
                 ENSMUSG00000090247 
                 biogenesis of 
                 −1.2713295 
                 0.30481544 
                 1.5761449 
                 −1.2713295 
               
               
                   
                   
                   
                 lysosome- 
               
               
                   
                   
                   
                 related 
               
               
                   
                   
                   
                 organelles 
               
               
                   
                   
                   
                 complex-1, 
               
               
                   
                   
                   
                 subunit 1 
               
               
                 Sdhc 
                 0.009144416 
                 ENSMUSG00000058076 
                 succinate 
                 −1.26805 
                 5.124012 
                 6.392062 
                 −1.26805 
               
               
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                 complex, 
               
               
                   
                   
                   
                 subunit C, 
               
               
                   
                   
                   
                 integral 
               
               
                   
                   
                   
                 membrane 
               
               
                   
                   
                   
                 protein 
               
               
                 Fosl2 
                 0.038066894 
                 ENSMUSG00000029135 
                 fos-like 
                 −1.265212 
                 8.133928 
                 9.39914 
                 −1.265212 
               
               
                   
                   
                   
                 antigen 2 
               
               
                 Agap3 
                 0.00044129 
                 ENSMUSG00000023353 
                 ArfGAP with 
                 −1.264696 
                 5.073 
                 6.337696 
                 −1.264696 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                   
                   
                 domain, 
               
               
                   
                   
                   
                 ankyrin 
               
               
                   
                   
                   
                 repeat and 
               
               
                   
                   
                   
                 PH domain 3 
               
               
                 Gm16372 
                 0.003350369 
                 ENSMUSG00000057160 
                 predicted 
                 −1.2619156 
                 −0.0380723 
                 1.2238433 
                 −1.2619156 
               
               
                   
                   
                   
                 pseudogene 
               
               
                   
                   
                   
                 16372 
               
               
                 Pip5k1b 
                 0.004221178 
                 ENSMUSG00000024867 
                 phosphatidylinositol- 
                 −1.258926 
                 5.6555843 
                 6.9145103 
                 −1.258926 
               
               
                   
                   
                   
                 4- 
               
               
                   
                   
                   
                 phosphate 5- 
               
               
                   
                   
                   
                 kinase, type 1 
               
               
                   
                   
                   
                 beta 
               
               
                 Avpi1 
                 0.034654055 
                 ENSMUSG00000018821 
                 arginine 
                 −1.255085 
                 2.6211839 
                 3.8762689 
                 −1.255085 
               
               
                   
                   
                   
                 vasopressin- 
               
               
                   
                   
                   
                 induced 1 
               
               
                 Atp5j2 
                 0.011021042 
                 ENSMUSG00000038690 
                 ATP synthase, 
                 −1.2517338 
                 3.8162642 
                 5.067998 
                 −1.2517338 
               
               
                   
                   
                   
                 H+ 
               
               
                   
                   
                   
                 transporting, 
               
               
                   
                   
                   
                 mitochondrial 
               
               
                   
                   
                   
                 F0 complex, 
               
               
                   
                   
                   
                 subunit F2 
               
               
                 Cyc1 
                 0.04513956 
                 ENSMUSG00000022551 
                 cytochrome 
                 −1.2489853 
                 5.1072073 
                 6.3561926 
                 −1.2489853 
               
               
                   
                   
                   
                 c-1 
               
               
                 Tollip 
                 0.001564898 
                 ENSMUSG00000025139 
                 toll 
                 −1.2389507 
                 4.1968327 
                 5.4357834 
                 −1.2389507 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 protein 
               
               
                 C330011M18Rik 
                 0.000299532 
                 ENSMUSG00000056753 
                 RIKEN cDNA 
                 −1.2348039 
                 −3.3956244 
                 −2.1608205 
                 −1.2348039 
               
               
                   
                   
                   
                 C330011M18 
               
               
                   
                   
                   
                 gene 
               
               
                 Fam108a 
                 0.003468877 
                 ENSMUSG00000003346 
                 family with 
                 −1.2336335 
                 3.2873702 
                 4.5210037 
                 −1.2336335 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 similarity 108, 
               
               
                   
                   
                   
                 member A 
               
               
                 Gm11273 
                 0.003542103 
                 ENSMUSG00000079941 
                 predicted 
                 −1.231031 
                 3.715511 
                 4.946542 
                 −1.231031 
               
               
                   
                   
                   
                 gene 11273 
               
               
                 Abhd14a 
                 0.001433305 
                 ENSMUSG00000042210 
                 abhydrolase 
                 −1.2276082 
                 0.67046493 
                 1.8980731 
                 −1.2276082 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 14A 
               
               
                 Pccb 
                 0.000628514 
                 ENSMUSG00000032527 
                 propionyl 
                 −1.2272532 
                 2.8235443 
                 4.0507975 
                 −1.2272532 
               
               
                   
                   
                   
                 Coenzyme A 
               
               
                   
                   
                   
                 carboxylase, 
               
               
                   
                   
                   
                 beta 
               
               
                   
                   
                   
                 polypeptide 
               
               
                 Sbno2 
                 0.001419982 
                 ENSMUSG00000035673 
                 strawberry 
                 −1.223022 
                 5.3650956 
                 6.5881176 
                 −1.223022 
               
               
                   
                   
                   
                 notch 
               
               
                   
                   
                   
                 homolog 2 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Yif1a 
                 0.008634817 
                 ENSMUSG00000024875 
                 Yip1 
                 −1.2178903 
                 1.7642471 
                 2.9821374 
                 −1.2178903 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 factor 
               
               
                   
                   
                   
                 homolog A ( S. cerevisiae ) 
               
               
                 Pip5kl1 
                 0.000696783 
                 ENSMUSG00000046854 
                 phosphatidylinositol- 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 4- 
               
               
                   
                   
                   
                 phosphate 5- 
               
               
                   
                   
                   
                 kinase-like 1 
               
               
                 Tnfrsf17 
                 0.001270444 
                 ENSMUSG00000022496 
                 tumor 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 necrosis 
               
               
                   
                   
                   
                 factor 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 superfamily, 
               
               
                   
                   
                   
                 member 17 
               
               
                 Slc10a6 
                 0.00129448 
                 ENSMUSG00000029321 
                 solute carrier 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 family 10 
               
               
                   
                   
                   
                 (sodium/bile 
               
               
                   
                   
                   
                 acid 
               
               
                   
                   
                   
                 cotransporter 
               
               
                   
                   
                   
                 family), 
               
               
                   
                   
                   
                 member 6 
               
               
                 Rhox2d 
                 0.001357955 
                 ENSMUSG00000079634 
                 reproductive 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 homeobox 2D 
               
               
                 Adamts16 
                 0.001422754 
                 ENSMUSG00000049538 
                 a disintegrin- 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 like and 
               
               
                   
                   
                   
                 metallopeptidase 
               
               
                   
                   
                   
                 (reprolysin 
               
               
                   
                   
                   
                 type) with 
               
               
                   
                   
                   
                 thrombospondin 
               
               
                   
                   
                   
                 type 1 
               
               
                   
                   
                   
                 motif, 16 
               
               
                 Adcy1 
                 0.001623965 
                 ENSMUSG00000020431 
                 adenylate 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 cyclase 1 
               
               
                 4933402P03Rik 
                 0.002350824 
                 ENSMUSG00000044084 
                 RIKEN cDNA 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 4933402P03 
               
               
                   
                   
                   
                 gene 
               
               
                 Gm16619 
                 0.002409908 
                 ENSMUSG00000086303 
                 predicted 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 gene, 16619 
               
               
                 Crb3 
                 0.002483939 
                 ENSMUSG00000044279 
                 crumbs 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 homolog 3 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Fbxo17 
                 0.002832668 
                 ENSMUSG00000030598 
                 F-box protein 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 4.2168817 
               
               
                   
                   
                   
                 17 
               
               
                 Podnl1 
                 0.003043215 
                 ENSMUSG00000012889 
                 podocan-like 1 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                 Iglon5 
                 0.003664683 
                 ENSMUSG00000013367 
                 IgLON family 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 member 5 
               
               
                 Wdr16 
                 0.004747208 
                 ENSMUSG00000020904 
                 WD repeat 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 domain 16 
               
               
                 Slc28a1 
                 0.004920505 
                 ENSMUSG00000025726 
                 solute carrier 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 family 28 
               
               
                   
                   
                   
                 (sodium- 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 nucleoside 
               
               
                   
                   
                   
                 transporter), 
               
               
                   
                   
                   
                 member 1 
               
               
                 Hspg2 
                 0.005137672 
                 ENSMUSG00000028763 
                 perlecan 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 (heparan 
               
               
                   
                   
                   
                 sulfate 
               
               
                   
                   
                   
                 proteoglycan 
               
               
                   
                   
                   
                 2) 
               
               
                 Cpne9 
                 0.005249562 
                 ENSMUSG00000030270 
                 copine family 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 member IX 
               
               
                 Ttc23l 
                 0.006339658 
                 ENSMUSG00000022249 
                 tetratricopeptide 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 repeat 
               
               
                   
                   
                   
                 domain 23- 
               
               
                   
                   
                   
                 like 
               
               
                 Ppp1r1b 
                 0.007002014 
                 ENSMUSG00000061718 
                 protein 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 phosphatase 
               
               
                   
                   
                   
                 1, regulatory 
               
               
                   
                   
                   
                 (inhibitor) 
               
               
                   
                   
                   
                 subunit 1B 
               
               
                 Acsbg2 
                 0.007208475 
                 ENSMUSG00000024207 
                 acyl-CoA 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 synthetase 
               
               
                   
                   
                   
                 bubblegum 
               
               
                   
                   
                   
                 family 
               
               
                   
                   
                   
                 member 2 
               
               
                 Peli3 
                 0.014013367 
                 ENSMUSG00000024901 
                 pellino 3 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                 Myo15b 
                 0.018579457 
                 ENSMUSG00000034427 
                 myosin XVB 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                 Scn4a 
                 0.018845024 
                 ENSMUSG00000001027 
                 sodium 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 channel, 
               
               
                   
                   
                   
                 voltage- 
               
               
                   
                   
                   
                 gated, type 
               
               
                   
                   
                   
                 IV, alpha 
               
               
                 Sh3bp4 
                 0.021253621 
                 ENSMUSG00000036206 
                 SH3-domain 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 4 
               
               
                 Gcom1 
                 0.02231107 
                 ENSMUSG00000041361 
                 GRINL1A 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 complex 
               
               
                   
                   
                   
                 locus 
               
               
                 Faim2 
                 0.035814784 
                 ENSMUSG00000023011 
                 Fas apoptotic 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 inhibitory 
               
               
                   
                   
                   
                 molecule 2 
               
               
                 Sox10 
                 0.04996452 
                 ENSMUSG00000033006 
                 SRY-box 
                 −1.2168817 
                 −5.5476274 
                 −4.3307457 
                 −1.2168817 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 gene 10 
               
               
                 Letm1 
                 0.001400281 
                 ENSMUSG00000005299 
                 leucine 
                 −1.207101 
                 4.858223 
                 6.065324 
                 −1.207101 
               
               
                   
                   
                   
                 zipper-EF- 
               
               
                   
                   
                   
                 hand 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 transmembrane 
               
               
                   
                   
                   
                 protein 1 
               
               
                 Obfc1 
                 0.033878557 
                 ENSMUSG00000042694 
                 oligonucleotide/ 
                 −1.2036425 
                 3.3048155 
                 4.508458 
                 −1.2036425 
               
               
                   
                   
                   
                 oligosaccharide- 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 fold 
               
               
                   
                   
                   
                 containing 1 
               
               
                 Tnfaip3 
                 0.002788399 
                 ENSMUSG00000019850 
                 tumor 
                 −1.201921 
                 4.3407774 
                 5.5426984 
                 −1.201921 
               
               
                   
                   
                   
                 necrosis 
               
               
                   
                   
                   
                 factor, alpha- 
               
               
                   
                   
                   
                 induced 
               
               
                   
                   
                   
                 protein 3 
               
               
                 Gnpda1 
                 0.01936977 
                 ENSMUSG00000052102 
                 glucosamine- 
                 −1.1803564 
                 4.0962286 
                 5.276585 
                 −1.1803564 
               
               
                   
                   
                   
                 6-phosphate 
               
               
                   
                   
                   
                 deaminase 1 
               
               
                 4921507L20Rik 
                 0.000400257 
                 ENSMUSG00000027196 
                 RIKEN cDNA 
                 −1.1803559 
                 −2.8106618 
                 −1.6303059 
                 −1.1803559 
               
               
                   
                   
                   
                 4921507L20 
               
               
                   
                   
                   
                 gene 
               
               
                 Gcnt7 
                 0.002288528 
                 ENSMUSG00000074569 
                 glucosaminyl 
                 −1.1803559 
                 −2.8106618 
                 −1.6303059 
                 −1.1803559 
               
               
                   
                   
                   
                 (N-acetyl) 
               
               
                   
                   
                   
                 transferase 
               
               
                   
                   
                   
                 family 
               
               
                   
                   
                   
                 member 7 
               
               
                 Gm16714 
                 0.005287915 
                 ENSMUSG00000085339 
                 predicted 
                 −1.1803559 
                 −2.8106618 
                 −1.6303059 
                 −1.1803559 
               
               
                   
                   
                   
                 gene, 16714 
               
               
                 Gm10642 
                 0.004257144 
                 ENSMUSG00000074213 
                 predicted 
                 −1.1803559 
                 0.18933822 
                 1.3696941 
                 −1.1803559 
               
               
                   
                   
                   
                 gene 10642 
               
               
                 Kif5a 
                 0.003976241 
                 ENSMUSG00000074657 
                 kinesin family 
                 −1.1786551 
                 3.4404259 
                 4.619081 
                 −1.1786551 
               
               
                   
                   
                   
                 member 5A 
               
               
                 Ucp2 
                 0.018080156 
                 ENSMUSG00000033685 
                 uncoupling 
                 −1.174402 
                 8.331445 
                 9.505847 
                 −1.174402 
               
               
                   
                   
                   
                 protein 2 
               
               
                   
                   
                   
                 (mitochondrial, 
               
               
                   
                   
                   
                 proton 
               
               
                   
                   
                   
                 carrier) 
               
               
                 Stx4a 
                 0.001855345 
                 ENSMUSG00000030805 
                 syntaxin 4A 
                 −1.1708516 
                 4.2838554 
                 5.454707 
                 −1.1708516 
               
               
                   
                   
                   
                 (placental) 
               
               
                 Arpc4 
                 0.04566701 
                 ENSMUSG00000079426 
                 actin related 
                 −1.1692152 
                 6.6474032 
                 7.8166184 
                 −1.1692152 
               
               
                   
                   
                   
                 protein 2/3 
               
               
                   
                   
                   
                 complex, 
               
               
                   
                   
                   
                 subunit 4 
               
               
                 Tyrobp 
                 0.006254981 
                 ENSMUSG00000030579 
                 TYRO protein 
                 −1.1689372 
                 6.1623178 
                 7.331255 
                 −1.1689372 
               
               
                   
                   
                   
                 tyrosine 
               
               
                   
                   
                   
                 kinase 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 
               
               
                 1810014F10Rik 
                 0.006210305 
                 ENSMUSG00000025466 
                 RIKEN cDNA 
                 −1.1683084 
                 1.813829 
                 2.9821374 
                 −1.1683084 
               
               
                   
                   
                   
                 1810014F10 
               
               
                   
                   
                   
                 gene 
               
               
                 Git1 
                 0.017137151 
                 ENSMUSG00000011877 
                 G protein- 
                 −1.1681207 
                 5.449866 
                 6.6179867 
                 −1.1681207 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 kinase- 
               
               
                   
                   
                   
                 interactor 1 
               
               
                 Hemk1 
                 0.00164007 
                 ENSMUSG00000032579 
                 HemK 
                 −1.1644144 
                 −1.5882694 
                 −0.423855 
                 −1.1644144 
               
               
                   
                   
                   
                 methyltransferase 
               
               
                   
                   
                   
                 family 
               
               
                   
                   
                   
                 member 1 
               
               
                 Akr7a5 
                 0.001301134 
                 ENSMUSG00000028743 
                 aldo-keto 
                 −1.1609256 
                 1.7129 
                 2.8738256 
                 −1.1609256 
               
               
                   
                   
                   
                 reductase 
               
               
                   
                   
                   
                 family 7, 
               
               
                   
                   
                   
                 member A5 
               
               
                   
                   
                   
                 (aflatoxin 
               
               
                   
                   
                   
                 aldehyde 
               
               
                   
                   
                   
                 reductase) 
               
               
                 Gng7 
                 0.011786759 
                 ENSMUSG00000048240 
                 guanine 
                 −1.1600361 
                 −0.9361927 
                 0.22384338 
                 −1.1600361 
               
               
                   
                   
                   
                 nucleotide 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein (G 
               
               
                   
                   
                   
                 protein), 
               
               
                   
                   
                   
                 gamma 7 
               
               
                 Lfng 
                 0.002728639 
                 ENSMUSG00000029570 
                 LFNG O- 
                 −1.1599504 
                 4.0801086 
                 5.240059 
                 −1.1599504 
               
               
                   
                   
                   
                 fucosylpeptide 
               
               
                   
                   
                   
                 3-beta-N- 
               
               
                   
                   
                   
                 acetylglucosaminyl- 
               
               
                   
                   
                   
                 transferase 
               
               
                 4930481A15Rik 
                 0.00970437 
                 ENSMUSG00000086938 
                 RIKEN cDNA 
                 −1.1568013 
                 −0.1476968 
                 1.0091045 
                 −1.1568013 
               
               
                   
                   
                   
                 4930481A15 
               
               
                   
                   
                   
                 gene 
               
               
                 Sema4g 
                 0.009896757 
                 ENSMUSG00000025207 
                 sema domain, 
                 −1.1494124 
                 1.4623566 
                 2.611769 
                 −1.1494124 
               
               
                   
                   
                   
                 immunoglobulin 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 (Ig), 
               
               
                   
                   
                   
                 transmembrane 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 (TM) and 
               
               
                   
                   
                   
                 short 
               
               
                   
                   
                   
                 cytoplasmic 
               
               
                   
                   
                   
                 domain, 
               
               
                   
                   
                   
                 (semaphorin) 
               
               
                   
                   
                   
                 4G 
               
               
                 Eef2k 
                 0.027855942 
                 ENSMUSG00000035064 
                 eukaryotic 
                 −1.148943 
                 2.248232 
                 3.397175 
                 −1.148943 
               
               
                   
                   
                   
                 elongation 
               
               
                   
                   
                   
                 factor-2 
               
               
                   
                   
                   
                 kinase 
               
               
                 Marveld1 
                 0.01568347 
                 ENSMUSG00000044345 
                 MARVEL 
                 −1.1408279 
                 3.5142686 
                 4.6550965 
                 −1.1408279 
               
               
                   
                   
                   
                 (membrane- 
               
               
                   
                   
                   
                 associating) 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 1 
               
               
                 Med29 
                 0.000937494 
                 ENSMUSG00000003444 
                 mediator 
                 −1.1378936 
                 2.1200755 
                 3.2579691 
                 −1.1378936 
               
               
                   
                   
                   
                 complex 
               
               
                   
                   
                   
                 subunit 29 
               
               
                 Ndufv1 
                 0.004069016 
                 ENSMUSG00000037916 
                 NADH 
                 −1.1364661 
                 5.3525686 
                 6.4890347 
                 −1.1364661 
               
               
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                 (ubiquinone) 
               
               
                   
                   
                   
                 flavoprotein 1 
               
               
                 Idh3b 
                 0.001815378 
                 ENSMUSG00000027406 
                 isocitrate 
                 −1.1333637 
                 5.6107016 
                 6.7440653 
                 −1.1333637 
               
               
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                 3 (NAD+) 
               
               
                   
                   
                   
                 beta 
               
               
                 Slc9a1 
                 0.049830776 
                 ENSMUSG00000028854 
                 solute carrier 
                 −1.1203177 
                 3.5262167 
                 4.6465344 
                 −1.1203177 
               
               
                   
                   
                   
                 family 9 
               
               
                   
                   
                   
                 (sodium/hydrogen 
               
               
                   
                   
                   
                 exchanger), 
               
               
                   
                   
                   
                 member 1 
               
               
                 1110005A03Rik 
                 0.011171196 
                 ENSMUSG00000090266 
                 RIKEN cDNA 
                 −1.1139733 
                 1.6267434 
                 2.7407167 
                 −1.1139733 
               
               
                   
                   
                   
                 1110005A03 
               
               
                   
                   
                   
                 gene 
               
               
                 Adamts10 
                 0.003044179 
                 ENSMUSG00000024299 
                 a disintegrin- 
                 −1.107314 
                 1.6704649 
                 2.7777789 
                 −1.107314 
               
               
                   
                   
                   
                 like and 
               
               
                   
                   
                   
                 metallopeptidase 
               
               
                   
                   
                   
                 (reprolysin 
               
               
                   
                   
                   
                 type) with 
               
               
                   
                   
                   
                 thrombospondin 
               
               
                   
                   
                   
                 type 1 
               
               
                   
                   
                   
                 motif, 10 
               
               
                 Atp5e 
                 0.000939308 
                 ENSMUSG00000016252 
                 ATP synthase, 
                 −1.1058641 
                 3.9308052 
                 5.0366693 
                 −1.1058641 
               
               
                   
                   
                   
                 H+ 
               
               
                   
                   
                   
                 transporting, 
               
               
                   
                   
                   
                 mitochondrial 
               
               
                   
                   
                   
                 F1 complex, 
               
               
                   
                   
                   
                 epsilon 
               
               
                   
                   
                   
                 subunit 
               
               
                 Sirt5 
                 0.009139757 
                 ENSMUSG00000054021 
                 sirtuin 5 
                 −1.103014 
                 1.4117305 
                 2.5147445 
                 −1.103014 
               
               
                   
                   
                   
                 (silent mating 
               
               
                   
                   
                   
                 type 
               
               
                   
                   
                   
                 information 
               
               
                   
                   
                   
                 regulation 2 
               
               
                   
                   
                   
                 homolog) 5 
               
               
                   
                   
                   
                 ( S. cerevisiae ) 
               
               
                 49305200O4Rik 
                 0.012646059 
                 ENSMUSG00000074039 
                 RIKEN cDNA 
                 −1.1023534 
                 0.43726566 
                 1.5396191 
                 −1.1023534 
               
               
                   
                   
                   
                 4930520O04 
               
               
                   
                   
                   
                 gene 
               
               
                 Pydc4 
                 0.02548906 
                 ENSMUSG00000073491 
                 pyrin domain 
                 −1.1018054 
                 1.6811913 
                 2.7829967 
                 −1.1018054 
               
               
                   
                   
                   
                 containing 4 
               
               
                 Nfatc1 
                 0.002607991 
                 ENSMUSG00000033016 
                 nuclear factor 
                 −1.0996833 
                 7.4641047 
                 8.563788 
                 −1.0996833 
               
               
                   
                   
                   
                 of activated 
               
               
                   
                   
                   
                 T-cells, 
               
               
                   
                   
                   
                 cytoplasmic, 
               
               
                   
                   
                   
                 calcineurin- 
               
               
                   
                   
                   
                 dependent 1 
               
               
                 Sirt3 
                 0.000476384 
                 ENSMUSG00000025486 
                 sirtuin 3 
                 −1.0970113 
                 1.3987916 
                 2.4958029 
                 −1.0970113 
               
               
                   
                   
                   
                 (silent mating 
               
               
                   
                   
                   
                 type 
               
               
                   
                   
                   
                 information 
               
               
                   
                   
                   
                 regulation 2, 
               
               
                   
                   
                   
                 homolog) 3 
               
               
                   
                   
                   
                 ( S. cerevisiae ) 
               
               
                 Nkain1 
                 0.026548363 
                 ENSMUSG00000078532 
                 Na+/K+ 
                 −1.0950936 
                 2.166618 
                 3.2617116 
                 −1.0950936 
               
               
                   
                   
                   
                 transporting 
               
               
                   
                   
                   
                 ATPase 
               
               
                   
                   
                   
                 interacting 1 
               
               
                 Tmem179b 
                 0.004654881 
                 ENSMUSG00000079437 
                 transmembrane 
                 −1.0883923 
                 2.3390853 
                 3.4274776 
                 −1.0883923 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 179B 
               
               
                 Egr1 
                 0.011464391 
                 ENSMUSG00000038418 
                 early growth 
                 −1.0853431 
                 0.7336586 
                 1.8190017 
                 −1.0853431 
               
               
                   
                   
                   
                 response 1 
               
               
                 Fdxr 
                 0.018414063 
                 ENSMUSG00000018861 
                 ferredoxin 
                 −1.0834726 
                 3.332296 
                 4.4157686 
                 −1.0834726 
               
               
                   
                   
                   
                 reductase 
               
               
                 Ptov1 
                 0.003783276 
                 ENSMUSG00000038502 
                 prostate 
                 −1.076344 
                 3.743927 
                 4.820271 
                 −1.076344 
               
               
                   
                   
                   
                 tumor over 
               
               
                   
                   
                   
                 expressed 
               
               
                   
                   
                   
                 gene 1 
               
               
                 Nradd 
                 0.0219546 
                 ENSMUSG00000032491 
                 neurotrophin 
                 −1.0700967 
                 1.7129 
                 2.7829967 
                 −1.0700967 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 death domain 
               
               
                 A230051G13Rik 
                 0.031146139 
                 ENSMUSG00000049287 
                 RIKEN cDNA 
                 −1.0672655 
                 2.8427804 
                 3.9100459 
                 −1.0672655 
               
               
                   
                   
                   
                 A230051G13 
               
               
                   
                   
                   
                 gene 
               
               
                 Gm9982 
                 0.001856765 
                 ENSMUSG00000055831 
                 predicted 
                 −1.064879 
                 −3.0736964 
                 −2.0088174 
                 −1.064879 
               
               
                   
                   
                   
                 gene 9982 
               
               
                 Gm10645 
                 0.004558912 
                 ENSMUSG00000074228 
                 predicted 
                 −1.064879 
                 −3.0736964 
                 −2.0088174 
                 −1.064879 
               
               
                   
                   
                   
                 gene 10645 
               
               
                 Tas1r3 
                 0.005695173 
                 ENSMUSG00000029072 
                 taste 
                 −1.064879 
                 −2.0736964 
                 −1.0088174 
                 −1.064879 
               
               
                   
                   
                   
                 receptor, 
               
               
                   
                   
                   
                 type 1, 
               
               
                   
                   
                   
                 member 3 
               
               
                 Adcy6 
                 0.001144709 
                 ENSMUSG00000022994 
                 adenylate 
                 −1.0648789 
                 −5.3956246 
                 −4.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 cyclase 6 
               
               
                 Rgs12 
                 0.002267373 
                 ENSMUSG00000029101 
                 regulator of 
                 −1.0648789 
                 −3.3956244 
                 −2.3307455 
                 −1.0648789 
               
               
                   
                   
                   
                 G-protein 
               
               
                   
                   
                   
                 signaling 12 
               
               
                 Olfr212 
                 0.002351982 
                 ENSMUSG00000053251 
                 olfactory 
                 −1.0648789 
                 −5.3956246 
                 −4.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 receptor 212 
               
               
                 1700054O19Rik 
                 0.004014643 
                 ENSMUSG00000057293 
                 RIKEN cDNA 
                 −1.0648789 
                 −5.3956246 
                 −4.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 1700054O19 
               
               
                   
                   
                   
                 gene 
               
               
                 Ccdc67 
                 0.007290532 
                 ENSMUSG00000039977 
                 coiled-coil 
                 −1.0648789 
                 −5.3956246 
                 −4.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 67 
               
               
                 C4b 
                 0.008590216 
                 ENSMUSG00000073418 
                 complement 
                 −1.0648789 
                 −2.3956244 
                 −1.3307455 
                 −1.0648789 
               
               
                   
                   
                   
                 component 
               
               
                   
                   
                   
                 4B (Childo 
               
               
                   
                   
                   
                 blood group) 
               
               
                 Arhgef17 
                 0.009287045 
                 ENSMUSG00000032875 
                 Rho guanine 
                 −1.0648789 
                 −3.3956244 
                 −2.3307455 
                 −1.0648789 
               
               
                   
                   
                   
                 nucleotide 
               
               
                   
                   
                   
                 exchange 
               
               
                   
                   
                   
                 factor (GEF) 
               
               
                   
                   
                   
                 17 
               
               
                 Slc36a3 
                 0.013117594 
                 ENSMUSG00000049491 
                 solute carrier 
                 −1.0648789 
                 −5.3956246 
                 −4.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 family 36 
               
               
                   
                   
                   
                 (proton/amino 
               
               
                   
                   
                   
                 acid 
               
               
                   
                   
                   
                 symporter), 
               
               
                   
                   
                   
                 member 3 
               
               
                 Gm20468 
                 0.013459157 
                 ENSMUSG00000092539 
                 predicted 
                 −1.0648789 
                 −5.3956246 
                 −4.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 gene 20468 
               
               
                 4930455G09Rik 
                 0.013695496 
                 ENSMUSG00000085761 
                 RIKEN cDNA 
                 −1.0648789 
                 −3.3956244 
                 −2.3307455 
                 −1.0648789 
               
               
                   
                   
                   
                 4930455G09 
               
               
                   
                   
                   
                 gene 
               
               
                 Wap 
                 0.01899181 
                 ENSMUSG00000000381 
                 whey acidic 
                 −1.0648789 
                 −5.3956246 
                 −4.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 protein 
               
               
                 Ccdc54 
                 0.028815286 
                 ENSMUSG00000050685 
                 coiled-coil 
                 −1.0648789 
                 −5.3956246 
                 −4.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 54 
               
               
                 Tmem130 
                 0.03130156 
                 ENSMUSG00000043388 
                 transmembrane 
                 −1.0648789 
                 −5.3956246 
                 −4.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 130 
               
               
                 Nrcam 
                 0.045242175 
                 ENSMUSG00000020598 
                 neuron-glia- 
                 −1.0648789 
                 −5.3956246 
                 −4.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 CAM-related 
               
               
                   
                   
                   
                 cell adhesion 
               
               
                   
                   
                   
                 molecule 
               
               
                 Bfsp2 
                 0.006345339 
                 ENSMUSG00000032556 
                 beaded 
                 −1.0648789 
                 −4.3956246 
                 −3.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 filament 
               
               
                   
                   
                   
                 structural 
               
               
                   
                   
                   
                 protein 2, 
               
               
                   
                   
                   
                 phakinin 
               
               
                 Rab27b 
                 0.007012791 
                 ENSMUSG00000024511 
                 RAB27b, 
                 −1.0648789 
                 −4.3956246 
                 −3.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 member RAS 
               
               
                   
                   
                   
                 oncogene 
               
               
                   
                   
                   
                 family 
               
               
                 Aqp7 
                 0.017064577 
                 ENSMUSG00000028427 
                 aquaporin 7 
                 −1.0648789 
                 −4.3956246 
                 −3.3307457 
                 −1.0648789 
               
               
                 4930451E10Rik 
                 0.01750742 
                 ENSMUSG00000069223 
                 RIKEN cDNA 
                 −1.0648789 
                 −4.3956246 
                 −3.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 4930451E10 
               
               
                   
                   
                   
                 gene 
               
               
                 Ms4a4b 
                 0.03696975 
                 ENSMUSG00000056290 
                 membrane- 
                 −1.0648789 
                 −4.3956246 
                 −3.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 spanning 4- 
               
               
                   
                   
                   
                 domains, 
               
               
                   
                   
                   
                 subfamily A, 
               
               
                   
                   
                   
                 member 4B 
               
               
                 4930529M08Rik 
                 0.037663873 
                 ENSMUSG00000037143 
                 RIKEN cDNA 
                 −1.0648789 
                 −4.3956246 
                 −3.3307457 
                 −1.0648789 
               
               
                   
                   
                   
                 4930529M08 
               
               
                   
                   
                   
                 gene 
               
               
                 Rab11fip4 
                 0.01102629 
                 ENSMUSG00000017639 
                 RAB11 family 
                 −1.0648788 
                 −3.8106618 
                 −2.745783 
                 −1.0648788 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 protein 4 
               
               
                   
                   
                   
                 (class II) 
               
               
                 41887 
                 0.016744798 
                 ENSMUSG00000072214 
                 septin 5 
                 −1.0648788 
                 −3.8106618 
                 −2.745783 
                 −1.0648788 
               
               
                 Prx 
                 0.016224083 
                 ENSMUSG00000053198 
                 periaxin 
                 −1.0648788 
                 −2.2256994 
                 −1.1608206 
                 −1.0648788 
               
               
                 Dlec1 
                 0.03235247 
                 ENSMUSG00000038060 
                 deleted in 
                 −1.0648788 
                 −1.5882694 
                 −0.5233907 
                 −1.0648788 
               
               
                   
                   
                   
                 lung and 
               
               
                   
                   
                   
                 esophageal 
               
               
                   
                   
                   
                 cancer 1 
               
               
                 Rpl10a- 
                 0.017712247 
                 ENSMUSG00000061988 
                 ribosomal 
                 −1.0648787 
                 1.9966931 
                 3.0615718 
                 −1.0648787 
               
               
                 ps2 
                   
                   
                 protein L10A, 
               
               
                   
                   
                   
                 pseudogene 2 
               
               
                 Cyfip2 
                 0.009189907 
                 ENSMUSG00000020340 
                 cytoplasmic 
                 −1.0582762 
                 2.3791628 
                 3.437439 
                 −1.0582762 
               
               
                   
                   
                   
                 FMR1 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 protein 2 
               
               
                 Fgd6 
                 0.005464029 
                 ENSMUSG00000020021 
                 FYVE, RhoGEF 
                 −1.0570075 
                 4.296119 
                 5.3531265 
                 −1.0570075 
               
               
                   
                   
                   
                 and PH 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 6 
               
               
                 Spef1 
                 0.006124181 
                 ENSMUSG00000027329 
                 sperm 
                 −1.0517034 
                 0.38573536 
                 1.4374388 
                 −1.0517034 
               
               
                   
                   
                   
                 flagellar 1 
               
               
                 Rab34 
                 0.023153191 
                 ENSMUSG00000002059 
                 RAB34, 
                 −1.0480704 
                 2.6211839 
                 3.6692543 
                 −1.0480704 
               
               
                   
                   
                   
                 member of 
               
               
                   
                   
                   
                 RAS 
               
               
                   
                   
                   
                 oncogene 
               
               
                   
                   
                   
                 family 
               
               
                 Klc2 
                 0.001976282 
                 ENSMUSG00000024862 
                 kinesin light 
                 −1.0417025 
                 2.5759192 
                 3.6176217 
                 −1.0417025 
               
               
                   
                   
                   
                 chain 2 
               
               
                 Slc2a4 
                 0.006559952 
                 ENSMUSG00000018566 
                 solute carrier 
                 −1.0406312 
                 −0.4887338 
                 0.55189747 
                 −1.0406312 
               
               
                   
                   
                   
                 family 2 
               
               
                   
                   
                   
                 (facilitated 
               
               
                   
                   
                   
                 glucose 
               
               
                   
                   
                   
                 transporter), 
               
               
                   
                   
                   
                 member 4 
               
               
                 Map2k3 
                 0.003899702 
                 ENSMUSG00000018932 
                 mitogen- 
                 −1.0403227 
                 6.526588 
                 7.5669107 
                 −1.0403227 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 kinase kinase 3 
               
               
                 Dad1 
                 0.00630479 
                 ENSMUSG00000022174 
                 defender 
                 −1.0402053 
                 4.695811 
                 5.7360163 
                 −1.0402053 
               
               
                   
                   
                   
                 against cell 
               
               
                   
                   
                   
                 death 1 
               
               
                 Gm14455 
                 0.004350234 
                 ENSMUSG00000087633 
                 predicted 
                 −1.0397879 
                 −0.5376434 
                 0.50214446 
                 −1.0397879 
               
               
                   
                   
                   
                 gene 14455 
               
               
                 Ak3 
                 0.006733093 
                 ENSMUSG00000024782 
                 adenylate 
                 −1.0376728 
                 4.4340982 
                 5.471771 
                 −1.0376728 
               
               
                   
                   
                   
                 kinase 3 
               
               
                 Glce 
                 0.007387917 
                 ENSMUSG00000032252 
                 glucuronyl 
                 −1.032552 
                 3.6239665 
                 4.6565185 
                 −1.032552 
               
               
                   
                   
                   
                 C5-epimerase 
               
               
                 Mtap7d1 
                 0.00833793 
                 ENSMUSG00000028849 
                 microtubule- 
                 −1.031302 
                 5.0462823 
                 6.0775843 
                 −1.031302 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 protein 7 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 1 
               
               
                 Ulk3 
                 0.002965013 
                 ENSMUSG00000032308 
                 unc-51-like 
                 −1.0307307 
                 2.022228 
                 3.0529587 
                 −1.0307307 
               
               
                   
                   
                   
                 kinase 3 ( C. elegans ) 
               
               
                 Ppap2c 
                 0.01108149 
                 ENSMUSG00000052151 
                 phosphatidic 
                 −1.0295459 
                 2.8805 
                 3.9100459 
                 −1.0295459 
               
               
                   
                   
                   
                 acid 
               
               
                   
                   
                   
                 phosphatase 
               
               
                   
                   
                   
                 type 2C 
               
               
                 Anapc2 
                 0.001523701 
                 ENSMUSG00000026965 
                 anaphase 
                 −1.0289692 
                 4.8331943 
                 5.8621635 
                 −1.0289692 
               
               
                   
                   
                   
                 promoting 
               
               
                   
                   
                   
                 complex 
               
               
                   
                   
                   
                 subunit 2 
               
               
                 Aldoart1 
                 0.013166931 
                 ENSMUSG00000059343 
                 aldolase 1A 
                 −1.028117 
                 5.360098 
                 6.388215 
                 −1.028117 
               
               
                   
                   
                   
                 retrogene 1 
               
               
                 N4bp3 
                 0.039391436 
                 ENSMUSG00000001053 
                 NEDD4 
                 −1.0253504 
                 −0.186171 
                 0.83917946 
                 −1.0253504 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 3 
               
               
                 Repin1 
                 0.00851355 
                 ENSMUSG00000052751 
                 replication 
                 −1.0077979 
                 1.4623566 
                 2.4701545 
                 −1.0077979 
               
               
                   
                   
                   
                 initiator 1 
               
               
                 Nudt14 
                 0.003012999 
                 ENSMUSG00000002804 
                 nudix 
                 −1.0052901 
                 2.0390038 
                 3.0442939 
                 −1.0052901 
               
               
                   
                   
                   
                 (nucleoside 
               
               
                   
                   
                   
                 diphosphate 
               
               
                   
                   
                   
                 linked moiety 
               
               
                   
                   
                   
                 X)-type motif 
               
               
                   
                   
                   
                 14 
               
               
                 A830007P12Rik 
                 0.020650838 
                 ENSMUSG00000059555 
                 RIKEN cDNA 
                 −0.9985294 
                 4.9001446 
                 5.898674 
                 −0.9985294 
               
               
                   
                   
                   
                 A830007P12 
               
               
                   
                   
                   
                 gene 
               
               
                 Aldoa 
                 0.002948088 
                 ENSMUSG00000030695 
                 aldolase A, 
                 −0.983461 
                 8.502977 
                 9.486438 
                 −0.983461 
               
               
                   
                   
                   
                 fructose- 
               
               
                   
                   
                   
                 bisphosphate 
               
               
                 Arc 
                 0.016652526 
                 ENSMUSG00000022602 
                 activity 
                 −0.9824167 
                 −1.2256994 
                 −0.2432828 
                 −0.9824167 
               
               
                   
                   
                   
                 regulated 
               
               
                   
                   
                   
                 cytoskeletal- 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 protein 
               
               
                 Rgl2 
                 0.008882542 
                 ENSMUSG00000041354 
                 ral guanine 
                 −0.979752 
                 5.2135544 
                 6.1933064 
                 −0.979752 
               
               
                   
                   
                   
                 nucleotide 
               
               
                   
                   
                   
                 dissociation 
               
               
                   
                   
                   
                 stimulator- 
               
               
                   
                   
                   
                 like 2 
               
               
                 Shpk 
                 0.019699099 
                 ENSMUSG00000005951 
                 sedoheptulokinase 
                 −0.9781672 
                 0.5112662 
                 1.4894334 
                 −0.9781672 
               
               
                 Aga 
                 0.00395918 
                 ENSMUSG00000031521 
                 aspartylglucosaminidase 
                 −0.9780013 
                 1.8711622 
                 2.8491635 
                 −0.9780013 
               
               
                 C230037L18Rik 
                 0.016271891 
                 ENSMUSG00000084915 
                 RIKEN cDNA 
                 −0.977416 
                 −1.3081615 
                 −0.3307455 
                 −0.977416 
               
               
                   
                   
                   
                 C230037L18 
               
               
                   
                   
                   
                 gene 
               
               
                 Il17rc 
                 0.018987024 
                 ENSMUSG00000030281 
                 interleukin 17 
                 −0.9750822 
                 0.4623566 
                 1.4374388 
                 −0.9750822 
               
               
                   
                   
                   
                 receptor C 
               
               
                 Ocel1 
                 0.019482028 
                 ENSMUSG00000002396 
                 occludin/ELL 
                 −0.9746046 
                 2.8570411 
                 3.8316457 
                 −0.9746046 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 1 
               
               
                 Il1rn 
                 0.004778137 
                 ENSMUSG00000026981 
                 interleukin 1 
                 −0.973403 
                 4.1836915 
                 5.1570945 
                 −0.973403 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 antagonist 
               
               
                 Rps16 
                 0.04162411 
                 ENSMUSG00000037563 
                 ribosomal 
                 −0.97321 
                 6.446333 
                 7.419543 
                 −0.97321 
               
               
                   
                   
                   
                 protein S16 
               
               
                 Zfp882 
                 0.008488793 
                 ENSMUSG00000089857 
                 zinc finger 
                 −0.9717693 
                 −2.3956244 
                 −1.4238551 
                 −0.9717693 
               
               
                   
                   
                   
                 protein 882 
               
               
                 Pold4 
                 0.008677183 
                 ENSMUSG00000024854 
                 polymerase 
                 −0.9683707 
                 1.0137666 
                 1.9821373 
                 −0.9683707 
               
               
                   
                   
                   
                 (DNA- 
               
               
                   
                   
                   
                 directed), 
               
               
                   
                   
                   
                 delta 4 
               
               
                 Man2b1 
                 0.04088014 
                 ENSMUSG00000005142 
                 mannosidase 
                 −0.9667725 
                 5.0232825 
                 5.990055 
                 −0.9667725 
               
               
                   
                   
                   
                 2, alpha B1 
               
               
                 Athl1 
                 0.00759034 
                 ENSMUSG00000062031 
                 ATH1, acid 
                 −0.9665135 
                 3.3857355 
                 4.352249 
                 −0.9665135 
               
               
                   
                   
                   
                 trehalase-like 
               
               
                   
                   
                   
                 1 (yeast) 
               
               
                 Fam195b 
                 0.012424714 
                 ENSMUSG00000061111 
                 family with 
                 −0.9629592 
                 4.3971663 
                 5.3601255 
                 −0.9629592 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 similarity 195, 
               
               
                   
                   
                   
                 member B 
               
               
                 Mtfp1 
                 0.046913996 
                 ENSMUSG00000004748 
                 mitochondrial 
                 −0.9624316 
                 1.5585719 
                 2.5210035 
                 −0.9624316 
               
               
                   
                   
                   
                 fission 
               
               
                   
                   
                   
                 process 1 
               
               
                 Cyb561d2 
                 0.010208104 
                 ENSMUSG00000037190 
                 cytochrome 
                 −0.9590102 
                 2.3322961 
                 3.2913063 
                 −0.9590102 
               
               
                   
                   
                   
                 b-561 domain 
               
               
                   
                   
                   
                 containing 2 
               
               
                 Tnfrsf11a 
                 0.010830157 
                 ENSMUSG00000026321 
                 tumor 
                 −0.958003 
                 6.045245 
                 7.003248 
                 −0.958003 
               
               
                   
                   
                   
                 necrosis 
               
               
                   
                   
                   
                 factor 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 superfamily, 
               
               
                   
                   
                   
                 member 11a 
               
               
                 9230115E21Rik 
                 0.010104352 
                 ENSMUSG00000074354 
                 RIKEN cDNA 
                 −0.9579636 
                 −2.5882695 
                 −1.6303059 
                 −0.9579636 
               
               
                   
                   
                   
                 9230115E21 
               
               
                   
                   
                   
                 gene 
               
               
                 Adamts1 
                 0.022076081 
                 ENSMUSG00000022893 
                 a disintegrin- 
                 −0.9579636 
                 −2.5882695 
                 −1.6303059 
                 −0.9579636 
               
               
                   
                   
                   
                 like and 
               
               
                   
                   
                   
                 metallopeptidase 
               
               
                   
                   
                   
                 (reprolysin 
               
               
                   
                   
                   
                 type) with 
               
               
                   
                   
                   
                 thrombospondin 
               
               
                   
                   
                   
                 type 1 
               
               
                   
                   
                   
                 motif, 1 
               
               
                 Kif7 
                 0.027391762 
                 ENSMUSG00000050382 
                 kinesin family 
                 −0.9579635 
                 −1.5882694 
                 −0.6303059 
                 −0.9579635 
               
               
                   
                   
                   
                 member 7 
               
               
                 Capn12 
                 0.012989306 
                 ENSMUSG00000054083 
                 calpain 12 
                 −0.9565671 
                 2.9172585 
                 3.8738256 
                 −0.9565671 
               
               
                 Gm16896 
                 0.020594148 
                 ENSMUSG00000085988 
                 predicted 
                 −0.9511457 
                 2.8805 
                 3.8316457 
                 −0.9511457 
               
               
                   
                   
                   
                 gene, 16896 
               
               
                 Naga 
                 0.004612528 
                 ENSMUSG00000022453 
                 N-acetyl 
                 −0.9453887 
                 3.7966683 
                 4.742057 
                 −0.9453887 
               
               
                   
                   
                   
                 galactosaminidase, 
               
               
                   
                   
                   
                 alpha 
               
               
                 Aagab 
                 0.045944124 
                 ENSMUSG00000037257 
                 alpha- and 
                 −0.9409665 
                 5.1141505 
                 6.055117 
                 −0.9409665 
               
               
                   
                   
                   
                 gamma- 
               
               
                   
                   
                   
                 adaptin 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 
               
               
                 Gm2895 
                 0.013068641 
                 ENSMUSG00000091412 
                 predicted 
                 −0.9393479 
                 −2.8106618 
                 −1.8713139 
                 −0.9393479 
               
               
                   
                   
                   
                 gene 2895 
               
               
                 Ccdc90a 
                 0.012132604 
                 ENSMUSG00000021371 
                 coiled-coil 
                 −0.9371602 
                 3.0962288 
                 4.033389 
                 −0.9371602 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 90A 
               
               
                 Rgs11 
                 0.011104016 
                 ENSMUSG00000024186 
                 regulator of 
                 −0.9327752 
                 0.9263038 
                 1.859079 
                 −0.9327752 
               
               
                   
                   
                   
                 G-protein 
               
               
                   
                   
                   
                 signaling 11 
               
               
                 Hyi 
                 0.028181328 
                 ENSMUSG00000006395 
                 hydroxypyruvate 
                 −0.9299492 
                 0.99669313 
                 1.9266423 
                 −0.9299492 
               
               
                   
                   
                   
                 isomerase 
               
               
                   
                   
                   
                 homolog ( E. coli ) 
               
               
                 Gpr137 
                 0.049236804 
                 ENSMUSG00000024958 
                 G protein- 
                 −0.9295592 
                 3.1082015 
                 4.0377607 
                 −0.9295592 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 receptor 137 
               
               
                 Ndufs3 
                 0.006582539 
                 ENSMUSG00000005510 
                 NADH 
                 −0.9273753 
                 3.8451672 
                 4.7725425 
                 −0.9273753 
               
               
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                 (ubiquinone) 
               
               
                   
                   
                   
                 Fe—S protein 3 
               
               
                 Acot11 
                 0.010169235 
                 ENSMUSG00000034853 
                 acyl-CoA 
                 −0.9219208 
                 0.3322961 
                 1.2542169 
                 −0.9219208 
               
               
                   
                   
                   
                 thioesterase 
               
               
                   
                   
                   
                 11 
               
               
                 Cirbp 
                 0.03442582 
                 ENSMUSG00000045193 
                 cold inducible 
                 −0.919633 
                 3.076051 
                 3.995684 
                 −0.919633 
               
               
                   
                   
                   
                 RNA binding 
               
               
                   
                   
                   
                 protein 
               
               
                 Acvrl1 
                 0.017487064 
                 ENSMUSG00000000530 
                 activin A 
                 −0.9193378 
                 2.2337322 
                 3.15307 
                 −0.9193378 
               
               
                   
                   
                   
                 receptor, 
               
               
                   
                   
                   
                 type II-like 1 
               
               
                 Ccdc114 
                 0.036372237 
                 ENSMUSG00000040189 
                 coiled-coil 
                 −0.919028 
                 −0.6951846 
                 0.22384338 
                 −0.919028 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 114 
               
               
                 Snn 
                 0.013385386 
                 ENSMUSG00000037972 
                 stannin 
                 −0.9128759 
                 −3.0736964 
                 −2.1608205 
                 −0.9128759 
               
               
                 Msi1 
                 0.014250691 
                 ENSMUSG00000054256 
                 Musashi 
                 −0.9128759 
                 −3.0736964 
                 −2.1608205 
                 −0.9128759 
               
               
                   
                   
                   
                 homolog 
               
               
                   
                   
                   
                 1( Drosophila ) 
               
               
                 Cyth1 
                 0.048440345 
                 ENSMUSG00000017132 
                 cytohesin 1 
                 −0.9122796 
                 2.675838 
                 3.5881176 
                 −0.9122796 
               
               
                 Aldh16a1 
                 0.027805215 
                 ENSMUSG00000007833 
                 aldehyde 
                 −0.909904 
                 4.6811914 
                 5.5910954 
                 −0.909904 
               
               
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                 16 family, 
               
               
                   
                   
                   
                 member A1 
               
               
                 Rsph3a 
                 0.011015884 
                 ENSMUSG00000073471 
                 radial spoke 
                 −0.9093094 
                 2.4181566 
                 3.327466 
                 −0.9093094 
               
               
                   
                   
                   
                 3A homolog 
               
               
                   
                   
                   
                 ( Chlamydomonas ) 
               
               
                 Commd4 
                 0.008752169 
                 ENSMUSG00000032299 
                 COMM 
                 −0.908303 
                 2.9081564 
                 3.8164594 
                 −0.908303 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 4 
               
               
                 Flcn 
                 0.008794582 
                 ENSMUSG00000032633 
                 folliculin 
                 −0.9066836 
                 4.4716544 
                 5.378338 
                 −0.9066836 
               
               
                 1700020I14Rik 
                 0.002356395 
                 ENSMUSG00000085438 
                 RIKEN cDNA 
                 −0.9060127 
                 4.241 
                 5.1470127 
                 −0.9060127 
               
               
                   
                   
                   
                 1700020I14 
               
               
                   
                   
                   
                 gene 
               
               
                 Cd59b 
                 0.009062648 
                 ENSMUSG00000068686 
                 CD59b 
                 −0.8977688 
                 −0.3956244 
                 0.50214446 
                 −0.8977688 
               
               
                   
                   
                   
                 antigen 
               
               
                 Gm15489 
                 0.014427851 
                 ENSMUSG00000086942 
                 predicted 
                 −0.8949539 
                 −2.2256994 
                 −1.3307455 
                 −0.8949539 
               
               
                   
                   
                   
                 gene 15489 
               
               
                 Taf10 
                 0.016606517 
                 ENSMUSG00000043866 
                 TAF10 RNA 
                 −0.8943495 
                 4.8247538 
                 5.7191033 
                 −0.8943495 
               
               
                   
                   
                   
                 polymerase II, 
               
               
                   
                   
                   
                 TATA box 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein (TBP)- 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 factor 
               
               
                 Eif2c4 
                 0.011220387 
                 ENSMUSG00000042500 
                 eukaryotic 
                 −0.8931125 
                 2.804048 
                 3.6971605 
                 −0.8931125 
               
               
                   
                   
                   
                 translation 
               
               
                   
                   
                   
                 initiation 
               
               
                   
                   
                   
                 factor 2C, 4 
               
               
                 2810422J05Rik 
                 0.002751657 
                 ENSMUSG00000055553 
                 RIKEN cDNA 
                 −0.892449 
                 7.259236 
                 8.151685 
                 −0.892449 
               
               
                   
                   
                   
                 2810422J05 
               
               
                   
                   
                   
                 gene 
               
               
                 Aldoart2 
                 0.014008217 
                 ENSMUSG00000063129 
                 aldolase 1 A 
                 −0.889758 
                 4.009517 
                 4.899275 
                 −0.889758 
               
               
                   
                   
                   
                 retrogene 2 
               
               
                 Fbrsl1 
                 0.020696755 
                 ENSMUSG00000043323 
                 fibrosin-like 1 
                 −0.8856542 
                 2.3458426 
                 3.2314968 
                 −0.8856542 
               
               
                 Suv420h2 
                 0.034955982 
                 ENSMUSG00000059851 
                 suppressor of 
                 −0.8856541 
                 3.6677709 
                 4.553425 
                 −0.8856541 
               
               
                   
                   
                   
                 variegation 4- 
               
               
                   
                   
                   
                 20 homolog 2 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Rgs14 
                 0.008254785 
                 ENSMUSG00000052087 
                 regulator of 
                 −0.8804542 
                 0.24823192 
                 1.1286861 
                 −0.8804542 
               
               
                   
                   
                   
                 G-protein 
               
               
                   
                   
                   
                 signaling 14 
               
               
                 Dhx34 
                 0.016695064 
                 ENSMUSG00000006019 
                 DEAH (Asp- 
                 −0.8802828 
                 3.1855762 
                 4.065859 
                 −0.8802828 
               
               
                   
                   
                   
                 Glu-Ala-His) 
               
               
                   
                   
                   
                 box 
               
               
                   
                   
                   
                 polypeptide 
               
               
                   
                   
                   
                 34 
               
               
                 Orai2 
                 0.01243197 
                 ENSMUSG00000039747 
                 ORAI calcium 
                 −0.8786246 
                 4.897847 
                 5.7764716 
                 −0.8786246 
               
               
                   
                   
                   
                 release- 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 calcium 
               
               
                   
                   
                   
                 modulator 2 
               
               
                 Cope 
                 0.015722413 
                 ENSMUSG00000055681 
                 coatomer 
                 −0.8782422 
                 3.4020374 
                 4.2802796 
                 −0.8782422 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 complex, 
               
               
                   
                   
                   
                 subunit 
               
               
                   
                   
                   
                 epsilon 
               
               
                 Gm3550 
                 0.006914831 
                 ENSMUSG00000078240 
                 predicted 
                 −0.8767266 
                 2.4435794 
                 3.320306 
                 −0.8767266 
               
               
                   
                   
                   
                 gene 3550 
               
               
                 Tspyl1 
                 0.010131083 
                 ENSMUSG00000047514 
                 testis-specific 
                 −0.8765944 
                 5.1190896 
                 5.995684 
                 −0.8765944 
               
               
                   
                   
                   
                 protein, Y- 
               
               
                   
                   
                   
                 encoded-like 1 
               
               
                 1810013L24Rik 
                 0.008725129 
                 ENSMUSG00000022507 
                 RIKEN cDNA 
                 −0.876027 
                 5.614204 
                 6.490231 
                 −0.876027 
               
               
                   
                   
                   
                 1810013L24 
               
               
                   
                   
                   
                 gene 
               
               
                 D4Wsu53e 
                 0.008402507 
                 ENSMUSG00000037266 
                 DNA 
                 −0.8759332 
                 6.209855 
                 7.0857882 
                 −0.8759332 
               
               
                   
                   
                   
                 segment, Chr 
               
               
                   
                   
                   
                 4, Wayne 
               
               
                   
                   
                   
                 State 
               
               
                   
                   
                   
                 University 53, 
               
               
                   
                   
                   
                 expressed 
               
               
                 Ttn 
                 0.006356048 
                 ENSMUSG00000051747 
                 titin 
                 −0.8746564 
                 1.0137666 
                 1.888423 
                 −0.8746564 
               
               
                 Tmem192 
                 0.029768782 
                 ENSMUSG00000025521 
                 transmembrane 
                 −0.8737595 
                 3.6811912 
                 4.5549507 
                 −0.8737595 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 192 
               
               
                 Gm6189 
                 0.006221308 
                 ENSMUSG00000090637 
                 predicted 
                 −0.8722337 
                 −1.8106617 
                 −0.938428 
                 −0.8722337 
               
               
                   
                   
                   
                 gene 6189 
               
               
                 Atp6ap2 
                 0.035808034 
                 ENSMUSG00000031007 
                 ATPase, H+ 
                 −0.872028 
                 7.740566 
                 8.612594 
                 −0.872028 
               
               
                   
                   
                   
                 transporting, 
               
               
                   
                   
                   
                 lysosomal 
               
               
                   
                   
                   
                 accessory 
               
               
                   
                   
                   
                 protein 2 
               
               
                 Zfp524 
                 0.03309677 
                 ENSMUSG00000051184 
                 zinc finger 
                 −0.8684815 
                 0.38573536 
                 1.2542169 
                 −0.8684815 
               
               
                   
                   
                   
                 protein 524 
               
               
                 Pgls 
                 0.016186675 
                 ENSMUSG00000031807 
                 6- 
                 −0.8678807 
                 4.4197593 
                 5.28764 
                 −0.8678807 
               
               
                   
                   
                   
                 phosphogluconolactonase 
               
               
                 Nhlrc3 
                 0.044700302 
                 ENSMUSG00000042997 
                 NHL repeat 
                 −0.8672788 
                 3.1551225 
                 4.0224013 
                 −0.8672788 
               
               
                   
                   
                   
                 containing 3 
               
               
                 Slc9a5 
                 0.017414166 
                 ENSMUSG00000014786 
                 solute carrier 
                 −0.8671144 
                 2.523239 
                 3.3903534 
                 −0.8671144 
               
               
                   
                   
                   
                 family 9 
               
               
                   
                   
                   
                 (sodium/hydrogen 
               
               
                   
                   
                   
                 exchanger), 
               
               
                   
                   
                   
                 member 5 
               
               
                 Ctsz 
                 0.025800172 
                 ENSMUSG00000016256 
                 cathepsin Z 
                 −0.8654295 
                 8.136001 
                 9.0014305 
                 −0.8654295 
               
               
                 Rps15 
                 0.015647907 
                 ENSMUSG00000063457 
                 ribosomal 
                 −0.8634447 
                 5.6838603 
                 6.547305 
                 −0.8634447 
               
               
                   
                   
                   
                 protein S15 
               
               
                 Gaa 
                 0.040927023 
                 ENSMUSG00000025579 
                 glucosidase, 
                 −0.85985 
                 5.17518 
                 6.03503 
                 −0.85985 
               
               
                   
                   
                   
                 alpha, acid 
               
               
                 Map3k10 
                 0.011791729 
                 ENSMUSG00000040390 
                 mitogen- 
                 −0.8566368 
                 2.1435344 
                 3.0001712 
                 −0.8566368 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 kinase kinase 
               
               
                   
                   
                   
                 kinase 10 
               
               
                 Zfp526 
                 0.029923318 
                 ENSMUSG00000046541 
                 zinc finger 
                 −0.8533748 
                 2.4561245 
                 3.3094993 
                 −0.8533748 
               
               
                   
                   
                   
                 protein 526 
               
               
                 Hist1h3g 
                 0.014537657 
                 ENSMUSG00000062417 
                 histone 
                 −0.8491501 
                 −1.2256994 
                 −0.3765493 
                 −0.8491501 
               
               
                   
                   
                   
                 cluster 1, H3g 
               
               
                 Gm6055 
                 0.032020975 
                 ENSMUSG00000062081 
                 predicted 
                 −0.8490165 
                 4.051459 
                 4.9004755 
                 −0.8490165 
               
               
                   
                   
                   
                 gene 6055 
               
               
                 C030037D09Rik 
                 0.044817787 
                 ENSMUSG00000087574 
                 RIKEN cDNA 
                 −0.8468781 
                 0.9619277 
                 1.8088058 
                 −0.8468781 
               
               
                   
                   
                   
                 C030037D09 
               
               
                   
                   
                   
                 gene 
               
               
                 Zswim7 
                 0.026769519 
                 ENSMUSG00000014243 
                 zinc finger, 
                 −0.8460816 
                 1.9880799 
                 2.8341615 
                 −0.8460816 
               
               
                   
                   
                   
                 SWIM-type 
               
               
                   
                   
                   
                 containing 7 
               
               
                 F420014N23Rik 
                 0.017114388 
                 ENSMUSG00000086597 
                 RIKEN cDNA 
                 −0.8444889 
                 0.5112662 
                 1.3557551 
                 −0.8444889 
               
               
                   
                   
                   
                 F420014N23 
               
               
                   
                   
                   
                 gene 
               
               
                 Ndufa9 
                 0.005276035 
                 ENSMUSG00000000399 
                 NADH 
                 −0.843957 
                 5.205218 
                 6.049175 
                 −0.843957 
               
               
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                 (ubiquinone) 
               
               
                   
                   
                   
                 1 alpha 
               
               
                   
                   
                   
                 subcomplex, 9 
               
               
                 Nr4a2 
                 0.012531522 
                 ENSMUSG00000026826 
                 nuclear 
                 −0.8424864 
                 1.1121702 
                 1.9546566 
                 −0.8424864 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 subfamily 4, 
               
               
                   
                   
                   
                 group A, 
               
               
                   
                   
                   
                 member 2 
               
               
                 Gm20422 
                 0.032568794 
                 ENSMUSG00000092544 
                 predicted 
                 −0.8424863 
                 −0.0033069 
                 0.83917946 
                 −0.8424863 
               
               
                   
                   
                   
                 gene 20422 
               
               
                 Map2k6 
                 0.02493559 
                 ENSMUSG00000020623 
                 mitogen- 
                 −0.8424863 
                 −1.5882694 
                 −0.7457831 
                 −0.8424863 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 kinase kinase 6 
               
               
                 Ulk1 
                 0.02368065 
                 ENSMUSG00000029512 
                 Unc-51 like 
                 −0.8396657 
                 2.6043756 
                 3.4440413 
                 −0.8396657 
               
               
                   
                   
                   
                 kinase 1 ( C. elegans ) 
               
               
                 Slc39a3 
                 0.01765952 
                 ENSMUSG00000046822 
                 solute carrier 
                 −0.8366098 
                 1.9619277 
                 2.7985375 
                 −0.8366098 
               
               
                   
                   
                   
                 family 39 
               
               
                   
                   
                   
                 (zinc 
               
               
                   
                   
                   
                 transporter), 
               
               
                   
                   
                   
                 member 3 
               
               
                 Tbc1d23 
                 0.022578219 
                 ENSMUSG00000022749 
                 TBC1 domain 
                 −0.8355326 
                 5.4475117 
                 6.2830443 
                 −0.8355326 
               
               
                   
                   
                   
                 family, 
               
               
                   
                   
                   
                 member 23 
               
               
                 Commd7 
                 0.023516493 
                 ENSMUSG00000056941 
                 COMM 
                 −0.8331583 
                 3.7233167 
                 4.556475 
                 −0.8331583 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 7 
               
               
                 Gm6410 
                 0.046976738 
                 ENSMUSG00000090435 
                 predicted 
                 −0.8304137 
                 −2.0736964 
                 −1.2432827 
                 −0.8304137 
               
               
                   
                   
                   
                 gene 6410 
               
               
                 1110032A03Rik 
                 0.019316237 
                 ENSMUSG00000037971 
                 RIKEN cDNA 
                 −0.8304134 
                 −0.0736962 
                 0.7567172 
                 −0.8304134 
               
               
                   
                   
                   
                 1110032A03 
               
               
                   
                   
                   
                 gene 
               
               
                 Pias4 
                 0.04347021 
                 ENSMUSG00000004934 
                 protein 
                 −0.8240743 
                 2.9352925 
                 3.7593668 
                 −0.8240743 
               
               
                   
                   
                   
                 inhibitor of 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 STAT 4 
               
               
                 Zkscan4 
                 0.02395805 
                 ENSMUSG00000054931 
                 zinc finger 
                 −0.8238707 
                 −0.1102221 
                 0.7136486 
                 −0.8238707 
               
               
                   
                   
                   
                 with KRAB 
               
               
                   
                   
                   
                 and SCAN 
               
               
                   
                   
                   
                 domains 4 
               
               
                 Tlcd2 
                 0.02366598 
                 ENSMUSG00000038217 
                 TLC domain 
                 −0.8175689 
                 0.7942001 
                 1.611769 
                 −0.8175689 
               
               
                   
                   
                   
                 containing 2 
               
               
                 Rap2a 
                 0.018936511 
                 ENSMUSG00000051615 
                 RAS related 
                 −0.8142681 
                 2.1357572 
                 2.9500253 
                 −0.8142681 
               
               
                   
                   
                   
                 protein 2a 
               
               
                 Snx7 
                 0.01534647 
                 ENSMUSG00000028007 
                 sorting nexin 7 
                 −0.8141116 
                 3.4020374 
                 4.216149 
                 −0.8141116 
               
               
                 Nfam1 
                 0.011470164 
                 ENSMUSG00000058099 
                 Nfat 
                 −0.813933 
                 4.460801 
                 5.274734 
                 −0.813933 
               
               
                   
                   
                   
                 activating 
               
               
                   
                   
                   
                 molecule 
               
               
                   
                   
                   
                 with ITAM 
               
               
                   
                   
                   
                 motif 1 
               
               
                 Paqr3 
                 0.025071675 
                 ENSMUSG00000055725 
                 progestin and 
                 −0.8123367 
                 2.7024078 
                 3.5147445 
                 −0.8123367 
               
               
                   
                   
                   
                 adipoQ 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 family 
               
               
                   
                   
                   
                 member III 
               
               
                 Orai2-ps 
                 0.02500956 
                 ENSMUSG00000090850 
                 ORAI calcium 
                 −0.8119425 
                 3.6838605 
                 4.495803 
                 −0.8119425 
               
               
                   
                   
                   
                 release- 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 calcium 
               
               
                   
                   
                   
                 modulator 2, 
               
               
                   
                   
                   
                 pseudogene 
               
               
                 Epn2 
                 0.017489249 
                 ENSMUSG00000001036 
                 epsin 2 
                 −0.8102112 
                 4.6623673 
                 5.4725785 
                 −0.8102112 
               
               
                 Bcl7b 
                 0.035148133 
                 ENSMUSG00000029681 
                 B-cell 
                 −0.8095522 
                 2.9966931 
                 3.8062453 
                 −0.8095522 
               
               
                   
                   
                   
                 CLL/lymphoma 
               
               
                   
                   
                   
                 7B 
               
               
                 3110056O03Rik 
                 0.033237558 
                 ENSMUSG00000035206 
                 RIKEN cDNA 
                 −0.8087448 
                 2.7942002 
                 3.602945 
                 −0.8087448 
               
               
                   
                   
                   
                 3110056O03 
               
               
                   
                   
                   
                 gene 
               
               
                 Mrpl22 
                 0.048313465 
                 ENSMUSG00000020514 
                 mitochondrial 
                 −0.8068106 
                 1.4623566 
                 2.2691672 
                 −0.8068106 
               
               
                   
                   
                   
                 ribosomal 
               
               
                   
                   
                   
                 protein L22 
               
               
                 Relt 
                 0.013668023 
                 ENSMUSG00000008318 
                 RELT tumor 
                 −0.8055995 
                 2.8664703 
                 3.6720698 
                 −0.8055995 
               
               
                   
                   
                   
                 necrosis 
               
               
                   
                   
                   
                 factor 
               
               
                   
                   
                   
                 receptor 
               
               
                 Naaladl1 
                 0.043300908 
                 ENSMUSG00000054999 
                 N-acetylated 
                 −0.8018445 
                 −1.4887338 
                 −0.6868893 
                 −0.8018445 
               
               
                   
                   
                   
                 alpha-linked 
               
               
                   
                   
                   
                 acidic 
               
               
                   
                   
                   
                 dipeptidase- 
               
               
                   
                   
                   
                 like 1 
               
               
                 Mtss1l 
                 0.010499953 
                 ENSMUSG00000033763 
                 metastasis 
                 −0.8018444 
                 −2.8106618 
                 −2.0088174 
                 −0.8018444 
               
               
                   
                   
                   
                 suppressor 1- 
               
               
                   
                   
                   
                 like 
               
               
                 1600029O15Rik 
                 0.015520786 
                 ENSMUSG00000057818 
                 RIKEN cDNA 
                 −0.8018444 
                 −3.8106618 
                 −3.0088174 
                 −0.8018444 
               
               
                   
                   
                   
                 1600029O15 
               
               
                   
                   
                   
                 gene 
               
               
                 Dao 
                 0.024370153 
                 ENSMUSG00000042096 
                 D-amino acid 
                 −0.8018444 
                 −3.8106618 
                 −3.0088174 
                 −0.8018444 
               
               
                   
                   
                   
                 oxidase 
               
               
                 BC125332 
                 0.025244432 
                 ENSMUSG00000041358 
                 cDNA 
                 −0.8018444 
                 −3.8106618 
                 −3.0088174 
                 −0.8018444 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 BC125332 
               
               
                 Fat2 
                 0.035712436 
                 ENSMUSG00000055333 
                 FAT tumor 
                 −0.8018444 
                 −3.8106618 
                 −3.0088174 
                 −0.8018444 
               
               
                   
                   
                   
                 suppressor 
               
               
                   
                   
                   
                 homolog 2 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Cabp7 
                 0.033022203 
                 ENSMUSG00000009075 
                 calcium 
                 −0.8018443 
                 −1.8106617 
                 −1.0088174 
                 −0.8018443 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 7 
               
               
                 Gm7353 
                 0.019511756 
                 ENSMUSG00000055452 
                 predicted 
                 −0.8002038 
                 3.6487699 
                 4.4489737 
                 −0.8002038 
               
               
                   
                   
                   
                 pseudogene 
               
               
                   
                   
                   
                 7353 
               
               
                 Rps8-ps1 
                 0.014286589 
                 ENSMUSG00000071303 
                 ribosomal 
                 −0.799268 
                 6.457295 
                 7.256563 
                 −0.799268 
               
               
                   
                   
                   
                 protein S8, 
               
               
                   
                   
                   
                 pseudogene 1 
               
               
                 Alcam 
                 0.02590528 
                 ENSMUSG00000022636 
                 activated 
                 −0.798258 
                 5.32889 
                 6.127148 
                 −0.798258 
               
               
                   
                   
                   
                 leukocyte cell 
               
               
                   
                   
                   
                 adhesion 
               
               
                   
                   
                   
                 molecule 
               
               
                 Fos 
                 0.044314757 
                 ENSMUSG00000021250 
                 FBJ 
                 −0.7970984 
                 5.28737 
                 6.0844684 
                 −0.7970984 
               
               
                   
                   
                   
                 osteosarcoma 
               
               
                   
                   
                   
                 oncogene 
               
               
                 Mtss1 
                 0.036628574 
                 ENSMUSG00000022353 
                 metastasis 
                 −0.796156 
                 5.59377 
                 6.389926 
                 −0.796156 
               
               
                   
                   
                   
                 suppressor 1 
               
               
                 Pcyox1 
                 0.020175328 
                 ENSMUSG00000029998 
                 prenylcysteine 
                 −0.7958059 
                 4.2732606 
                 5.0690665 
                 −0.7958059 
               
               
                   
                   
                   
                 oxidase 1 
               
               
                 Rnaseh2c 
                 0.022177652 
                 ENSMUSG00000024925 
                 ribonuclease 
                 −0.7937506 
                 1.7642471 
                 2.5579977 
                 −0.7937506 
               
               
                   
                   
                   
                 H2, subunit C 
               
               
                 Tab1 
                 0.01681519 
                 ENSMUSG00000022414 
                 TGF-beta 
                 −0.7932696 
                 3.2661538 
                 4.0594234 
                 −0.7932696 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 kinase 
               
               
                   
                   
                   
                 1/MAP3K7 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 1 
               
               
                 Rps3 
                 0.032059707 
                 ENSMUSG00000030744 
                 ribosomal 
                 −0.7917607 
                 7.8012853 
                 8.593046 
                 −0.7917607 
               
               
                   
                   
                   
                 protein S3 
               
               
                 Gm5507 
                 0.027941754 
                 ENSMUSG00000069376 
                 predicted 
                 −0.7911568 
                 5.7220187 
                 6.5131755 
                 −0.7911568 
               
               
                   
                   
                   
                 gene 5507 
               
               
                 Mrp63 
                 0.014859019 
                 ENSMUSG00000021967 
                 mitochondrial 
                 −0.7907952 
                 3.1240118 
                 3.914807 
                 −0.7907952 
               
               
                   
                   
                   
                 ribosomal 
               
               
                   
                   
                   
                 protein 63 
               
               
                 Solh 
                 0.027924877 
                 ENSMUSG00000037326 
                 small optic 
                 −0.7896872 
                 3.3492093 
                 4.1388965 
                 −0.7896872 
               
               
                   
                   
                   
                 lobes 
               
               
                   
                   
                   
                 homolog 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Adamts13 
                 0.02814318 
                 ENSMUSG00000014852 
                 a disintegrin- 
                 −0.7888179 
                 2.6650715 
                 3.4538894 
                 −0.7888179 
               
               
                   
                   
                   
                 like and 
               
               
                   
                   
                   
                 metallopeptidase 
               
               
                   
                   
                   
                 (reprolysin 
               
               
                   
                   
                   
                 type) with 
               
               
                   
                   
                   
                 thrombospondin 
               
               
                   
                   
                   
                 type 1 
               
               
                   
                   
                   
                 motif, 13 
               
               
                 Lsm4 
                 0.020239143 
                 ENSMUSG00000031848 
                 LSM4 
                 −0.7882819 
                 3.6071906 
                 4.3954725 
                 −0.7882819 
               
               
                   
                   
                   
                 homolog, U6 
               
               
                   
                   
                   
                 small nuclear 
               
               
                   
                   
                   
                 RNA 
               
               
                   
                   
                   
                 associated ( S. cerevisiae ) 
               
               
                 Triobp 
                 0.014277731 
                 ENSMUSG00000033088 
                 TRIO and F- 
                 −0.7874437 
                 3.3955383 
                 4.182982 
                 −0.7874437 
               
               
                   
                   
                   
                 actin binding 
               
               
                   
                   
                   
                 protein 
               
               
                 Gm16156 
                 0.012805327 
                 ENSMUSG00000087436 
                 predicted 
                 −0.787345 
                 1.5112662 
                 2.2986112 
                 −0.787345 
               
               
                   
                   
                   
                 gene 16156 
               
               
                 Kcnn4 
                 0.024224881 
                 ENSMUSG00000054342 
                 potassium 
                 −0.784895 
                 5.302212 
                 6.087107 
                 −0.784895 
               
               
                   
                   
                   
                 intermediate/ 
               
               
                   
                   
                   
                 small 
               
               
                   
                   
                   
                 conductance 
               
               
                   
                   
                   
                 calcium- 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 channel, 
               
               
                   
                   
                   
                 subfamily N, 
               
               
                   
                   
                   
                 member 4 
               
               
                 Trmt61a 
                 0.028067956 
                 ENSMUSG00000060950 
                 tRNA 
                 −0.783203 
                 4.398792 
                 5.181995 
                 −0.783203 
               
               
                   
                   
                   
                 methyltransferase 
               
               
                   
                   
                   
                 61 
               
               
                   
                   
                   
                 homolog A ( S. cerevisiae ) 
               
               
                 Tpra1 
                 0.032772 
                 ENSMUSG00000002871 
                 transmembrane 
                 −0.7817533 
                 2.1589644 
                 2.9407177 
                 −0.7817533 
               
               
                   
                   
                   
                 protein, 
               
               
                   
                   
                   
                 adipocyte 
               
               
                   
                   
                   
                 asscociated 1 
               
               
                 Adck4 
                 0.028475156 
                 ENSMUSG00000003762 
                 aarF domain 
                 −0.779902 
                 2.9172585 
                 3.6971605 
                 −0.779902 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 kinase 4 
               
               
                 Zfp189 
                 0.02446675 
                 ENSMUSG00000039634 
                 zinc finger 
                 −0.7799019 
                 0.3322961 
                 1.112198 
                 −0.7799019 
               
               
                   
                   
                   
                 protein 189 
               
               
                 Trak2 
                 0.029910393 
                 ENSMUSG00000026028 
                 trafficking 
                 −0.778933 
                 5.470109 
                 6.249042 
                 −0.778933 
               
               
                   
                   
                   
                 protein, 
               
               
                   
                   
                   
                 kinesin 
               
               
                   
                   
                   
                 binding 2 
               
               
                 Setd4 
                 0.039261803 
                 ENSMUSG00000022948 
                 SET domain 
                 −0.7753723 
                 2.0638072 
                 2.8391795 
                 −0.7753723 
               
               
                   
                   
                   
                 containing 4 
               
               
                 Ttc38 
                 0.015144606 
                 ENSMUSG00000035944 
                 tetratricopeptide 
                 −0.773416 
                 1.54689 
                 2.320306 
                 −0.773416 
               
               
                   
                   
                   
                 repeat 
               
               
                   
                   
                   
                 domain 38 
               
               
                 Ccdc88c 
                 0.02540553 
                 ENSMUSG00000021182 
                 coiled-coil 
                 −0.7721902 
                 3.7842848 
                 4.556475 
                 −0.7721902 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 88C 
               
               
                 Gm10159 
                 0.017318606 
                 ENSMUSG00000069972 
                 predicted 
                 −0.770136 
                 5.800363 
                 6.570499 
                 −0.770136 
               
               
                   
                   
                   
                 pseudogene 
               
               
                   
                   
                   
                 10159 
               
               
                 Aim1 
                 0.02232682 
                 ENSMUSG00000019866 
                 absent in 
                 −0.7701057 
                 5.5120173 
                 6.282123 
                 −0.7701057 
               
               
                   
                   
                   
                 melanoma 1 
               
               
                 Rab11b 
                 0.034848575 
                 ENSMUSG00000077450 
                 RAB11B, 
                 −0.7691937 
                 4.3492093 
                 5.118403 
                 −0.7691937 
               
               
                   
                   
                   
                 member RAS 
               
               
                   
                   
                   
                 oncogene 
               
               
                   
                   
                   
                 family 
               
               
                 Leprot 
                 0.02571553 
                 ENSMUSG00000035212 
                 leptin 
                 −0.7679413 
                 3.4654624 
                 4.2334037 
                 −0.7679413 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 overlapping 
               
               
                   
                   
                   
                 transcript 
               
               
                 Agap2 
                 0.020851009 
                 ENSMUSG00000025422 
                 ArfGAP with 
                 −0.7653184 
                 −1.3956243 
                 −0.6303059 
                 −0.7653184 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                   
                   
                 domain, 
               
               
                   
                   
                   
                 ankyrin 
               
               
                   
                   
                   
                 repeat and 
               
               
                   
                   
                   
                 PH domain 2 
               
               
                 Fbxl15 
                 0.026200434 
                 ENSMUSG00000025226 
                 F-box and 
                 −0.7637091 
                 0.71290016 
                 1.4766093 
                 −0.7637091 
               
               
                   
                   
                   
                 leucine-rich 
               
               
                   
                   
                   
                 repeat 
               
               
                   
                   
                   
                 protein 15 
               
               
                 Gm12942 
                 0.024523953 
                 ENSMUSG00000070737 
                 predicted 
                 −0.7623158 
                 0.81382906 
                 1.5761449 
                 −0.7623158 
               
               
                   
                   
                   
                 gene 12942 
               
               
                 Pts 
                 0.025246479 
                 ENSMUSG00000032067 
                 6-pyruvoyl- 
                 −0.7604849 
                 2.1279378 
                 2.8884227 
                 −0.7604849 
               
               
                   
                   
                   
                 tetrahydropterin 
               
               
                   
                   
                   
                 synthase 
               
               
                 1110019D14Rik 
                 0.027602369 
                 ENSMUSG00000084931 
                 RIKEN cDNA 
                 −0.7600241 
                 −0.0033069 
                 0.7567172 
                 −0.7600241 
               
               
                   
                   
                   
                 1110019D14 
               
               
                   
                   
                   
                 gene 
               
               
                 B230312A22Rik 
                 0.015634464 
                 ENSMUSG00000036002 
                 RIKEN cDNA 
                 −0.7591951 
                 3.7413666 
                 4.5005617 
                 −0.7591951 
               
               
                   
                   
                   
                 B230312A22 
               
               
                   
                   
                   
                 gene 
               
               
                 Pik3r1 
                 0.012770501 
                 ENSMUSG00000041417 
                 phosphatidylinositol 
                 −0.753873 
                 4.502221 
                 5.256094 
                 −0.753873 
               
               
                   
                   
                   
                 3- 
               
               
                   
                   
                   
                 kinase, 
               
               
                   
                   
                   
                 regulatory 
               
               
                   
                   
                   
                 subunit, 
               
               
                   
                   
                   
                 polypeptide 1 
               
               
                   
                   
                   
                 (p85 alpha) 
               
               
                 Plekhh3 
                 0.025038777 
                 ENSMUSG00000035172 
                 pleckstrin 
                 −0.7507702 
                 1.1279377 
                 1.8787079 
                 −0.7507702 
               
               
                   
                   
                   
                 homology 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing, 
               
               
                   
                   
                   
                 family H (with 
               
               
                   
                   
                   
                 MyTH4 
               
               
                   
                   
                   
                 domain) 
               
               
                   
                   
                   
                 member 3 
               
               
                 Rbm42 
                 0.016107807 
                 ENSMUSG00000036733 
                 RNA binding 
                 −0.743897 
                 4.178023 
                 4.92192 
                 −0.743897 
               
               
                   
                   
                   
                 motif protein 
               
               
                   
                   
                   
                 42 
               
               
                 Gm16287 
                 0.029231198 
                 ENSMUSG00000073739 
                 predicted 
                 −0.7429509 
                 −3.0736964 
                 −2.3307455 
                 −0.7429509 
               
               
                   
                   
                   
                 gene 16287 
               
               
                 Psd2 
                 0.024929984 
                 ENSMUSG00000024347 
                 pleckstrin and 
                 −0.7429507 
                 −1.4887338 
                 −0.7457831 
                 −0.7429507 
               
               
                   
                   
                   
                 Sec7 domain 
               
               
                   
                   
                   
                 containing 2 
               
               
                 Cyb561d1 
                 0.019253794 
                 ENSMUSG00000048796 
                 cytochrome 
                 −0.7429507 
                 3.2838557 
                 4.0268064 
                 −0.7429507 
               
               
                   
                   
                   
                 b-561 domain 
               
               
                   
                   
                   
                 containing 1 
               
               
                 Mob2 
                 0.022150464 
                 ENSMUSG00000025147 
                 MOB kinase 
                 −0.7429507 
                 3.0348282 
                 3.7777789 
                 −0.7429507 
               
               
                   
                   
                   
                 activator 2 
               
               
                 5830415F09Rik 
                 0.02634874 
                 ENSMUSG00000028331 
                 RIKEN cDNA 
                 −0.7429506 
                 0.24823192 
                 0.9911825 
                 −0.7429506 
               
               
                   
                   
                   
                 5830415F09 
               
               
                   
                   
                   
                 gene 
               
               
                 AK157302 
                 0.03351777 
                 ENSMUSG00000078139 
                 cDNA 
                 −0.7418299 
                 4.2572207 
                 4.9990506 
                 −0.7418299 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 AK157302 
               
               
                 Gm10154 
                 0.026876133 
                 ENSMUSG00000066116 
                 predicted 
                 −0.733413 
                 6.259459 
                 6.992872 
                 −0.733413 
               
               
                   
                   
                   
                 gene 10154 
               
               
                 Thap11 
                 0.032562416 
                 ENSMUSG00000036442 
                 THAP domain 
                 −0.7276657 
                 3.342468 
                 4.0701337 
                 −0.7276657 
               
               
                   
                   
                   
                 containing 11 
               
               
                 Ethe1 
                 0.027350841 
                 ENSMUSG00000064254 
                 ethylmalonic 
                 −0.7267101 
                 1.6704649 
                 2.397175 
                 −0.7267101 
               
               
                   
                   
                   
                 encephalopathy 1 
               
               
                 Rps26-ps1 
                 0.041135248 
                 ENSMUSG00000059775 
                 ribosomal 
                 −0.7250665 
                 5.626744 
                 6.3518105 
                 −0.7250665 
               
               
                   
                   
                   
                 protein S26, 
               
               
                   
                   
                   
                 pseudogene 1 
               
               
                 Zfp523 
                 0.021875188 
                 ENSMUSG00000024220 
                 zinc finger 
                 −0.7216739 
                 1.3987916 
                 2.1204655 
                 −0.7216739 
               
               
                   
                   
                   
                 protein 523 
               
               
                 Klhl9 
                 0.04047058 
                 ENSMUSG00000070923 
                 kelch-like 9 
                 −0.7213396 
                 4.7528524 
                 5.474192 
                 −0.7213396 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Tmem198 
                 0.024651697 
                 ENSMUSG00000051703 
                 transmembrane 
                 −0.7209243 
                 −0.3512302 
                 0.3696941 
                 −0.7209243 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 198 
               
               
                 Rps8 
                 0.04837038 
                 ENSMUSG00000047675 
                 ribosomal 
                 −0.7206627 
                 6.4615793 
                 7.182242 
                 −0.7206627 
               
               
                   
                   
                   
                 protein S8 
               
               
                 Nudt13 
                 0.026868425 
                 ENSMUSG00000021809 
                 nudix 
                 −0.7203802 
                 1.8617636 
                 2.5821438 
                 −0.7203802 
               
               
                   
                   
                   
                 (nucleoside 
               
               
                   
                   
                   
                 diphosphate 
               
               
                   
                   
                   
                 linked moiety 
               
               
                   
                   
                   
                 X)-type motif 
               
               
                   
                   
                   
                 13 
               
               
                 Psmb5 
                 0.038760804 
                 ENSMUSG00000022193 
                 proteasome 
                 −0.720298 
                 4.597314 
                 5.317612 
                 −0.720298 
               
               
                   
                   
                   
                 (prosome, 
               
               
                   
                   
                   
                 macropain) 
               
               
                   
                   
                   
                 subunit, beta 
               
               
                   
                   
                   
                 type 5 
               
               
                 Polr2e 
                 0.0348101 
                 ENSMUSG00000004667 
                 polymerase 
                 −0.7191351 
                 3.5142686 
                 4.2334037 
                 −0.7191351 
               
               
                   
                   
                   
                 (RNA) II (DNA 
               
               
                   
                   
                   
                 directed) 
               
               
                   
                   
                   
                 polypeptide E 
               
               
                 Comt 
                 0.015054342 
                 ENSMUSG00000000326 
                 catechol-O- 
                 −0.7187031 
                 3.4181569 
                 4.13686 
                 −0.7187031 
               
               
                   
                   
                   
                 methyltransferase 
               
               
                 Fam100a 
                 0.021507928 
                 ENSMUSG00000039568 
                 family with 
                 −0.7178386 
                 2.8186948 
                 3.5365334 
                 −0.7178386 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 similarity 100, 
               
               
                   
                   
                   
                 member A 
               
               
                 Dusp28 
                 0.011824952 
                 ENSMUSG00000047067 
                 dual 
                 −0.7169556 
                 0.2190855 
                 0.93604106 
                 −0.7169556 
               
               
                   
                   
                   
                 specificity 
               
               
                   
                   
                   
                 phosphatase 
               
               
                   
                   
                   
                 28 
               
               
                 5730528L13Rik 
                 0.033186235 
                 ENSMUSG00000039693 
                 RIKEN cDNA 
                 −0.7158044 
                 1.4372658 
                 2.1530702 
                 −0.7158044 
               
               
                   
                   
                   
                 5730528L13 
               
               
                   
                   
                   
                 gene 
               
               
                 Fbxl6 
                 0.036996942 
                 ENSMUSG00000022559 
                 F-box and 
                 −0.7127183 
                 3.9508893 
                 4.6636076 
                 −0.7127183 
               
               
                   
                   
                   
                 leucine-rich 
               
               
                   
                   
                   
                 repeat 
               
               
                   
                   
                   
                 protein 6 
               
               
                 Lrrc33 
                 0.03724786 
                 ENSMUSG00000052384 
                 leucine rich 
                 −0.7122502 
                 5.7997475 
                 6.5119977 
                 −0.7122502 
               
               
                   
                   
                   
                 repeat 
               
               
                   
                   
                   
                 containing 33 
               
               
                 Pik3ca 
                 0.040598534 
                 ENSMUSG00000027665 
                 phosphatidylinositol 
                 −0.712027 
                 4.800363 
                 5.51239 
                 −0.712027 
               
               
                   
                   
                   
                 3- 
               
               
                   
                   
                   
                 kinase, 
               
               
                   
                   
                   
                 catalytic, 
               
               
                   
                   
                   
                 alpha 
               
               
                   
                   
                   
                 polypeptide 
               
               
                 Sppl3 
                 0.04645074 
                 ENSMUSG00000029550 
                 signal peptide 
                 −0.7106166 
                 5.065855 
                 5.7764716 
                 −0.7106166 
               
               
                   
                   
                   
                 peptidase 3 
               
               
                 Rgs1 
                 0.017007569 
                 ENSMUSG00000026358 
                 regulator of 
                 −0.7068314 
                 3.6971326 
                 4.403964 
                 −0.7068314 
               
               
                   
                   
                   
                 G-protein 
               
               
                   
                   
                   
                 signaling 1 
               
               
                 Gcap14 
                 0.025004745 
                 ENSMUSG00000058690 
                 granule cell 
                 −0.706376 
                 4.172332 
                 4.878708 
                 −0.706376 
               
               
                   
                   
                   
                 antiserum 
               
               
                   
                   
                   
                 positive 14 
               
               
                 Rabgef1 
                 0.045662638 
                 ENSMUSG00000025340 
                 RAB guanine 
                 −0.705021 
                 4.49464 
                 5.199661 
                 −0.705021 
               
               
                   
                   
                   
                 nucleotide 
               
               
                   
                   
                   
                 exchange 
               
               
                   
                   
                   
                 factor (GEF) 1 
               
               
                 Vti1b 
                 0.029425714 
                 ENSMUSG00000021124 
                 vesicle 
                 −0.7047739 
                 6.4313216 
                 7.1360955 
                 −0.7047739 
               
               
                   
                   
                   
                 transport 
               
               
                   
                   
                   
                 through 
               
               
                   
                   
                   
                 interaction 
               
               
                   
                   
                   
                 with t- 
               
               
                   
                   
                   
                 SNAREs 1B 
               
               
                   
                   
                   
                 homolog 
               
               
                 Pter 
                 0.029844783 
                 ENSMUSG00000026730 
                 phosphotriesterase 
                 −0.7043781 
                 3.2410004 
                 3.9453785 
                 −0.7043781 
               
               
                   
                   
                   
                 related 
               
               
                 Lrmp 
                 0.024810746 
                 ENSMUSG00000030263 
                 lymphoid- 
                 −0.7032047 
                 5.2572207 
                 5.9604254 
                 −0.7032047 
               
               
                   
                   
                   
                 restricted 
               
               
                   
                   
                   
                 membrane 
               
               
                   
                   
                   
                 protein 
               
               
                 Exoc7 
                 0.024444766 
                 ENSMUSG00000020792 
                 exocyst 
                 −0.7030464 
                 3.73108 
                 4.4341264 
                 −0.7030464 
               
               
                   
                   
                   
                 complex 
               
               
                   
                   
                   
                 component 7 
               
               
                 2400003C14Rik 
                 0.047920387 
                 ENSMUSG00000031729 
                 RIKEN cDNA 
                 −0.7017847 
                 5.6838603 
                 6.385645 
                 −0.7017847 
               
               
                   
                   
                   
                 2400003C14 
               
               
                   
                   
                   
                 gene 
               
               
                 Gm8112 
                 0.040240075 
                 ENSMUSG00000074859 
                 predicted 
                 −0.6999323 
                 3.3659267 
                 4.065859 
                 −0.6999323 
               
               
                   
                   
                   
                 gene 8112 
               
               
                 Tjp3 
                 0.023516202 
                 ENSMUSG00000034917 
                 tight junction 
                 −0.6987509 
                 0.4623566 
                 1.1611075 
                 −0.6987509 
               
               
                   
                   
                   
                 protein 3 
               
               
                 Park7 
                 0.040839158 
                 ENSMUSG00000028964 
                 Parkinson 
                 −0.6974029 
                 5.5694385 
                 6.2668414 
                 −0.6974029 
               
               
                   
                   
                   
                 disease 
               
               
                   
                   
                   
                 (autosomal 
               
               
                   
                   
                   
                 recessive, 
               
               
                   
                   
                   
                 early onset) 7 
               
               
                 Gm10063 
                 0.036025446 
                 ENSMUSG00000059333 
                 predicted 
                 −0.6958537 
                 4.7743006 
                 5.4701543 
                 −0.6958537 
               
               
                   
                   
                   
                 gene 10063 
               
               
                 Gm6788 
                 0.020853998 
                 ENSMUSG00000090737 
                 predicted 
                 −0.6952334 
                 3.1161282 
                 3.8113616 
                 −0.6952334 
               
               
                   
                   
                   
                 gene 6788 
               
               
                 Nmnat1 
                 0.023781195 
                 ENSMUSG00000028992 
                 nicotinamide 
                 −0.6944067 
                 2.0137668 
                 2.7081735 
                 −0.6944067 
               
               
                   
                   
                   
                 nucleotide 
               
               
                   
                   
                   
                 adenylyltrans 
               
               
                   
                   
                   
                 ferase 1 
               
               
                 Tbc1d10b 
                 0.039930627 
                 ENSMUSG00000042492 
                 TBC1 domain 
                 −0.694137 
                 5.522494 
                 6.216631 
                 −0.694137 
               
               
                   
                   
                   
                 family, 
               
               
                   
                   
                   
                 member 10b 
               
               
                 Parp3 
                 0.03246012 
                 ENSMUSG00000023249 
                 poly (ADP- 
                 −0.6925622 
                 2.535113 
                 3.2276752 
                 −0.6925622 
               
               
                   
                   
                   
                 ribose) 
               
               
                   
                   
                   
                 polymerase 
               
               
                   
                   
                   
                 family, 
               
               
                   
                   
                   
                 member 3 
               
               
                 Vps52 
                 0.018454367 
                 ENSMUSG00000024319 
                 vacuolar 
                 −0.6916389 
                 4.8355966 
                 5.5272355 
                 −0.6916389 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 sorting 52 
               
               
                   
                   
                   
                 (yeast) 
               
               
                 Rps26 
                 0.047893744 
                 ENSMUSG00000025362 
                 ribosomal 
                 −0.6903605 
                 5.5454235 
                 6.235784 
                 −0.6903605 
               
               
                   
                   
                   
                 protein S26 
               
               
                 Immt 
                 0.030641051 
                 ENSMUSG00000052337 
                 inner 
                 −0.6881917 
                 6.283416 
                 6.9716077 
                 −0.6881917 
               
               
                   
                   
                   
                 membrane 
               
               
                   
                   
                   
                 protein, 
               
               
                   
                   
                   
                 mitochondrial 
               
               
                 Adap2 
                 0.040307727 
                 ENSMUSG00000020709 
                 ArfGAP with 
                 −0.6863671 
                 −1.6951845 
                 −1.0088174 
                 −0.6863671 
               
               
                   
                   
                   
                 dual PH 
               
               
                   
                   
                   
                 domains 2 
               
               
                 Vps39 
                 0.035322167 
                 ENSMUSG00000027291 
                 vacuolar 
                 −0.6844366 
                 4.9988384 
                 5.683275 
                 −0.6844366 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 sorting 39 
               
               
                   
                   
                   
                 (yeast) 
               
               
                 Fuca2 
                 0.043429524 
                 ENSMUSG00000019810 
                 fucosidase, 
                 −0.6837888 
                 4.6971326 
                 5.3809214 
                 −0.6837888 
               
               
                   
                   
                   
                 alpha-L-2, 
               
               
                   
                   
                   
                 plasma 
               
               
                 Dynlrb1 
                 0.030277705 
                 ENSMUSG00000047459 
                 dynein light 
                 −0.6834495 
                 2.2337322 
                 2.9171817 
                 −0.6834495 
               
               
                   
                   
                   
                 chain 
               
               
                   
                   
                   
                 roadblock- 
               
               
                   
                   
                   
                 type 1 
               
               
                 Mmgt2 
                 0.04851589 
                 ENSMUSG00000048497 
                 membrane 
                 −0.681381 
                 4.133806 
                 4.815187 
                 −0.681381 
               
               
                   
                   
                   
                 magnesium 
               
               
                   
                   
                   
                 transporter 2 
               
               
                 Zfpl1 
                 0.040050752 
                 ENSMUSG00000024792 
                 zinc finger 
                 −0.6790388 
                 3.1551225 
                 3.8341613 
                 −0.6790388 
               
               
                   
                   
                   
                 like protein 1 
               
               
                 Gm20457 
                 0.036167003 
                 ENSMUSG00000092187 
                 predicted 
                 −0.6786962 
                 0.64876974 
                 1.3274659 
                 −0.6786962 
               
               
                   
                   
                   
                 gene 20457 
               
               
                 Fam82b 
                 0.048664004 
                 ENSMUSG00000028229 
                 family with 
                 −0.6786962 
                 0.64876974 
                 1.3274659 
                 −0.6786962 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 similarity 82, 
               
               
                   
                   
                   
                 member B 
               
               
                 H2-Eb1 
                 0.037901763 
                 ENSMUSG00000060586 
                 histocompatibility 
                 −0.6778556 
                 −1.3081615 
                 −0.6303059 
                 −0.6778556 
               
               
                   
                   
                   
                 2, class 
               
               
                   
                   
                   
                 II antigen E 
               
               
                   
                   
                   
                 beta 
               
               
                 Blvra 
                 0.0474667 
                 ENSMUSG00000001999 
                 biliverdin 
                 −0.6718913 
                 3.8475497 
                 4.519441 
                 −0.6718913 
               
               
                   
                   
                   
                 reductase A 
               
               
                 Srcrb4d 
                 0.0354348 
                 ENSMUSG00000029699 
                 scavenger 
                 −0.6675433 
                 −0.6407369 
                 0.02680641 
                 −0.6675433 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 cysteine rich 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing, 
               
               
                   
                   
                   
                 group B (4 
               
               
                   
                   
                   
                 domains) 
               
               
                 Glud1 
                 0.04627992 
                 ENSMUSG00000021794 
                 glutamate 
                 −0.6664464 
                 6.44082 
                 7.1072664 
                 −0.6664464 
               
               
                   
                   
                   
                 dehydrogenase 1 
               
               
                 Fdx1l 
                 0.04709346 
                 ENSMUSG00000079677 
                 ferredoxin 1- 
                 −0.6660187 
                 4.133806 
                 4.7998247 
                 −0.6660187 
               
               
                   
                   
                   
                 like 
               
               
                 2610318N02Rik 
                 0.027701477 
                 ENSMUSG00000049916 
                 RIKEN cDNA 
                 −0.6646384 
                 1.2042885 
                 1.8689269 
                 −0.6646384 
               
               
                   
                   
                   
                 2610318N02 
               
               
                   
                   
                   
                 gene 
               
               
                 Cbara1 
                 0.025856437 
                 ENSMUSG00000020111 
                 calcium 
                 −0.6626866 
                 4.2838554 
                 4.946542 
                 −0.6626866 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 atopy-related 
               
               
                   
                   
                   
                 autoantigen 1 
               
               
                 AI837181 
                 0.037062764 
                 ENSMUSG00000047423 
                 expressed 
                 −0.6597565 
                 2.7842848 
                 3.4440413 
                 −0.6597565 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 AI837181 
               
               
                 Agk 
                 0.028081048 
                 ENSMUSG00000029916 
                 acylglycerol 
                 −0.6595563 
                 2.813829 
                 3.4733853 
                 −0.6595563 
               
               
                   
                   
                   
                 kinase 
               
               
                 Slc44a2 
                 0.027341165 
                 ENSMUSG00000057193 
                 solute carrier 
                 −0.6587429 
                 3.1627963 
                 3.8215392 
                 −0.6587429 
               
               
                   
                   
                   
                 family 44, 
               
               
                   
                   
                   
                 member 2 
               
               
                 Atp6v0d1 
                 0.02142147 
                 ENSMUSG00000013160 
                 ATPase, H+ 
                 −0.6567502 
                 6.2455244 
                 6.9022746 
                 −0.6567502 
               
               
                   
                   
                   
                 transporting, 
               
               
                   
                   
                   
                 lysosomal V0 
               
               
                   
                   
                   
                 subunit D1 
               
               
                 Adat3 
                 0.0407096 
                 ENSMUSG00000035370 
                 adenosine 
                 −0.6546907 
                 1.2337323 
                 1.888423 
                 −0.6546907 
               
               
                   
                   
                   
                 deaminase, 
               
               
                   
                   
                   
                 tRNA-specific 
               
               
                   
                   
                   
                 3, TAD2 
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
               
               
                 Dlx4 
                 0.029477518 
                 ENSMUSG00000020871 
                 distal-less 
                 −0.6498416 
                 −4.3956246 
                 −3.745783 
                 −0.6498416 
               
               
                   
                   
                   
                 homeobox 4 
               
               
                 Fzd9 
                 0.030664086 
                 ENSMUSG00000049551 
                 frizzled 
                 −0.6498416 
                 −4.3956246 
                 −3.745783 
                 −0.6498416 
               
               
                   
                   
                   
                 homolog 9 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Gm13031 
                 0.03036407 
                 ENSMUSG00000087698 
                 predicted 
                 −0.6498414 
                 −3.3956244 
                 −2.745783 
                 −0.6498414 
               
               
                   
                   
                   
                 gene 13031 
               
               
                 Jag2 
                 0.041047707 
                 ENSMUSG00000002799 
                 jagged 2 
                 −0.6498413 
                 −2.0736964 
                 −1.4238551 
                 −0.6498413 
               
               
                 Gm5665 
                 0.048196785 
                 ENSMUSG00000074863 
                 predicted 
                 −0.6498413 
                 −2.8106618 
                 −2.1608205 
                 −0.6498413 
               
               
                   
                   
                   
                 gene 5665 
               
               
                 Cdk18 
                 0.035990108 
                 ENSMUSG00000026437 
                 cyclin- 
                 −0.6487923 
                 5.4451537 
                 6.093946 
                 −0.6487923 
               
               
                   
                   
                   
                 dependent 
               
               
                   
                   
                   
                 kinase 18 
               
               
                 Wsb2 
                 0.048568413 
                 ENSMUSG00000029364 
                 WD repeat 
                 −0.6455825 
                 5.747759 
                 6.3933415 
                 −0.6455825 
               
               
                   
                   
                   
                 and SOCS 
               
               
                   
                   
                   
                 box- 
               
               
                   
                   
                   
                 containing 2 
               
               
                 Rpl14 
                 0.04038221 
                 ENSMUSG00000025794 
                 ribosomal 
                 −0.645187 
                 6.155603 
                 6.80079 
                 −0.645187 
               
               
                   
                   
                   
                 protein L14 
               
               
                 Gm11457 
                 0.044966727 
                 ENSMUSG00000086453 
                 predicted 
                 −0.6448752 
                 1.2042885 
                 1.8491637 
                 −0.6448752 
               
               
                   
                   
                   
                 gene 11457 
               
               
                 Adck5 
                 0.025202971 
                 ENSMUSG00000022550 
                 aarF domain 
                 −0.6416361 
                 3.6514995 
                 4.2931356 
                 −0.6416361 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 kinase 5 
               
               
                 Tmub2 
                 0.04888207 
                 ENSMUSG00000034757 
                 transmembrane 
                 −0.6409414 
                 2.6865246 
                 3.327466 
                 −0.6409414 
               
               
                   
                   
                   
                 and 
               
               
                   
                   
                   
                 ubiquitin-like 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 2 
               
               
                 Atp5l-ps1 
                 0.033605512 
                 ENSMUSG00000072460 
                 ATP synthase, 
                 −0.6403808 
                 3.2768009 
                 3.9171817 
                 −0.6403808 
               
               
                   
                   
                   
                 H+ 
               
               
                   
                   
                   
                 transporting, 
               
               
                   
                   
                   
                 mitochondrial 
               
               
                   
                   
                   
                 F0 complex, 
               
               
                   
                   
                   
                 subunit g, 
               
               
                   
                   
                   
                 pseudogene 1 
               
               
                 Rgs16 
                 0.04644141 
                 ENSMUSG00000026475 
                 regulator of 
                 −0.639681 
                 4.759194 
                 5.398875 
                 −0.639681 
               
               
                   
                   
                   
                 G-protein 
               
               
                   
                   
                   
                 signaling 16 
               
               
                 Rpl21- 
                 0.04064617 
                 ENSMUSG00000062152 
                 ribosomal 
                 −0.6384003 
                 3.3254747 
                 3.963875 
                 −0.6384003 
               
               
                 ps14 
                   
                   
                 protein L21, 
               
               
                   
                   
                   
                 pseudogene 
               
               
                   
                   
                   
                 14 
               
               
                 Snx11 
                 0.046817992 
                 ENSMUSG00000020876 
                 sorting nexin 
                 −0.634604 
                 3.0514588 
                 3.6860628 
                 −0.634604 
               
               
                   
                   
                   
                 11 
               
               
                 Nln 
                 0.048038434 
                 ENSMUSG00000021710 
                 neurolysin 
                 −0.6335058 
                 4.5365906 
                 5.1700964 
                 −0.6335058 
               
               
                   
                   
                   
                 (metallopeptidase 
               
               
                   
                   
                   
                 M3 
               
               
                   
                   
                   
                 family) 
               
               
                 Acss2 
                 0.039891824 
                 ENSMUSG00000027605 
                 acyl-CoA 
                 −0.6298728 
                 3.2042885 
                 3.8341613 
                 −0.6298728 
               
               
                   
                   
                   
                 synthetase 
               
               
                   
                   
                   
                 short-chain 
               
               
                   
                   
                   
                 family 
               
               
                   
                   
                   
                 member 2 
               
               
                 Gm16744 
                 0.04230707 
                 ENSMUSG00000086002 
                 predicted 
                 −0.6287797 
                 −0.8720624 
                 −0.2432828 
                 −0.6287797 
               
               
                   
                   
                   
                 gene, 16744 
               
               
                 1110051M20Rik 
                 0.042616416 
                 ENSMUSG00000040591 
                 RIKEN cDNA 
                 −0.627511 
                 4.2536316 
                 4.8811426 
                 −0.627511 
               
               
                   
                   
                   
                 1110051M20 
               
               
                   
                   
                   
                 gene 
               
               
                 Rab1b 
                 0.042926516 
                 ENSMUSG00000024870 
                 RAB1B, 
                 −0.6267397 
                 5.902438 
                 6.5291777 
                 −0.6267397 
               
               
                   
                   
                   
                 member RAS 
               
               
                   
                   
                   
                 oncogene 
               
               
                   
                   
                   
                 family 
               
               
                 Ndufs5 
                 0.027461376 
                 ENSMUSG00000028648 
                 NADH 
                 −0.6264772 
                 1.979415 
                 2.6058922 
                 −0.6264772 
               
               
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                 (ubiquinone) 
               
               
                   
                   
                   
                 Fe—S protein 5 
               
               
                 Tmem42 
                 0.034604322 
                 ENSMUSG00000066233 
                 transmembrane 
                 −0.6259945 
                 1.535113 
                 2.1611075 
                 −0.6259945 
               
               
                   
                   
                   
                 protein 42 
               
               
                 Mapkapk2 
                 0.03941688 
                 ENSMUSG00000016528 
                 MAP kinase- 
                 −0.6252842 
                 6.7155113 
                 7.3407955 
                 −0.6252842 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 kinase 2 
               
               
                 Stambpl1 
                 0.035237126 
                 ENSMUSG00000024776 
                 STAM binding 
                 −0.6250782 
                 5.4197593 
                 6.0448375 
                 −0.6250782 
               
               
                   
                   
                   
                 protein like 1 
               
               
                 Pgam2 
                 0.039034486 
                 ENSMUSG00000020475 
                 phosphoglycerate 
                 −0.6243063 
                 −1.1476969 
                 −0.5233907 
                 −0.6243063 
               
               
                   
                   
                   
                 mutase 2 
               
               
                 Fam160b1 
                 0.04417353 
                 ENSMUSG00000033478 
                 family with 
                 −0.6238462 
                 3.7336588 
                 4.357505 
                 −0.6238462 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 similarity 160, 
               
               
                   
                   
                   
                 member B1 
               
               
                 Ttll12 
                 0.048118092 
                 ENSMUSG00000016757 
                 tubulin 
                 −0.6235144 
                 4.5365906 
                 5.160105 
                 −0.6235144 
               
               
                   
                   
                   
                 tyrosine 
               
               
                   
                   
                   
                 ligase-like 
               
               
                   
                   
                   
                 family, 
               
               
                   
                   
                   
                 member 12 
               
               
                 Nudt15 
                 0.033909168 
                 ENSMUSG00000033405 
                 nudix 
                 −0.6220963 
                 1.7336587 
                 2.355755 
                 −0.6220963 
               
               
                   
                   
                   
                 (nucleoside 
               
               
                   
                   
                   
                 diphosphate 
               
               
                   
                   
                   
                 linked moiety 
               
               
                   
                   
                   
                 X)-type motif 
               
               
                   
                   
                   
                 15 
               
               
                 Tram2 
                 0.049381044 
                 ENSMUSG00000041779 
                 translocating 
                 −0.6220071 
                 1.8989964 
                 2.5210035 
                 −0.6220071 
               
               
                   
                   
                   
                 chain- 
               
               
                   
                   
                   
                 associating 
               
               
                   
                   
                   
                 membrane 
               
               
                   
                   
                   
                 protein 2 
               
               
                 Ociad2 
                 0.0425186 
                 ENSMUSG00000029153 
                 OCIA domain 
                 −0.6212722 
                 −1.3081615 
                 −0.6868893 
                 −0.6212722 
               
               
                   
                   
                   
                 containing 2 
               
               
                 Bloc1s3 
                 0.04529189 
                 ENSMUSG00000057667 
                 biogenesis of 
                 −0.620094 
                 2.2190855 
                 2.8391795 
                 −0.620094 
               
               
                   
                   
                   
                 lysosome- 
               
               
                   
                   
                   
                 related 
               
               
                   
                   
                   
                 organelles 
               
               
                   
                   
                   
                 complex-1, 
               
               
                   
                   
                   
                 subunit 3 
               
               
                 Rassf1 
                 0.037896954 
                 ENSMUSG00000010067 
                 Ras 
                 −0.6198733 
                 3.4309242 
                 4.0507975 
                 −0.6198733 
               
               
                   
                   
                   
                 association 
               
               
                   
                   
                   
                 (RalGDS/AF- 
               
               
                   
                   
                   
                 6) domain 
               
               
                   
                   
                   
                 family 
               
               
                   
                   
                   
                 member 1 
               
               
                 Sntb2 
                 0.038723968 
                 ENSMUSG00000041308 
                 syntrophin, 
                 −0.619171 
                 4.99991 
                 5.619081 
                 −0.619171 
               
               
                   
                   
                   
                 basic 2 
               
               
                 Kcnab2 
                 0.037089523 
                 ENSMUSG00000028931 
                 potassium 
                 −0.6191615 
                 4.422958 
                 5.0421195 
                 −0.6191615 
               
               
                   
                   
                   
                 voltage-gated 
               
               
                   
                   
                   
                 channel, 
               
               
                   
                   
                   
                 shaker- 
               
               
                   
                   
                   
                 related 
               
               
                   
                   
                   
                 subfamily, 
               
               
                   
                   
                   
                 beta member 2 
               
               
                 Rragc 
                 0.04885698 
                 ENSMUSG00000028646 
                 Ras-related 
                 −0.6159734 
                 6.085671 
                 6.7016444 
                 −0.6159734 
               
               
                   
                   
                   
                 GTP binding C 
               
               
                 Irf3 
                 0.038443018 
                 ENSMUSG00000003184 
                 interferon 
                 −0.615951 
                 3.2554274 
                 3.8713784 
                 −0.615951 
               
               
                   
                   
                   
                 regulatory 
               
               
                   
                   
                   
                 factor 3 
               
               
                 3110043O21Rik 
                 0.046679143 
                 ENSMUSG00000028300 
                 RIKEN cDNA 
                 −0.6140154 
                 5.588082 
                 6.2020974 
                 −0.6140154 
               
               
                   
                   
                   
                 3110043O21 
               
               
                   
                   
                   
                 gene 
               
               
                 Tnfaip8 
                 0.036621507 
                 ENSMUSG00000062210 
                 tumor 
                 −0.613772 
                 4.529188 
                 5.14296 
                 −0.613772 
               
               
                   
                   
                   
                 necrosis 
               
               
                   
                   
                   
                 factor, alpha- 
               
               
                   
                   
                   
                 induced 
               
               
                   
                   
                   
                 protein 8 
               
               
                 Dscr3 
                 0.034768607 
                 ENSMUSG00000022898 
                 Down 
                 −0.6132714 
                 4.3169026 
                 4.930174 
                 −0.6132714 
               
               
                   
                   
                   
                 syndrome 
               
               
                   
                   
                   
                 critical region 
               
               
                   
                   
                   
                 gene 3 
               
               
                 Ppp1r16a 
                 0.034497265 
                 ENSMUSG00000033819 
                 protein 
                 −0.6129417 
                 3.6487699 
                 4.2617116 
                 −0.6129417 
               
               
                   
                   
                   
                 phosphatase 
               
               
                   
                   
                   
                 1, regulatory 
               
               
                   
                   
                   
                 (inhibitor) 
               
               
                   
                   
                   
                 subunit 16A 
               
               
                 Rpl17-ps3 
                 0.041614436 
                 ENSMUSG00000069392 
                 ribosomal 
                 −0.609239 
                 6.650135 
                 7.259374 
                 −0.609239 
               
               
                   
                   
                   
                 protein L17, 
               
               
                   
                   
                   
                 pseudogene 3 
               
               
                 5430403G16Rik 
                 0.04923931 
                 ENSMUSG00000072763 
                 RIKEN cDNA 
                 −0.6085005 
                 0.4870187 
                 1.0955192 
                 −0.6085005 
               
               
                   
                   
                   
                 5430403G16 
               
               
                   
                   
                   
                 gene 
               
               
                 Mpst 
                 0.04476959 
                 ENSMUSG00000071711 
                 mercaptopyruvate 
                 −0.6077339 
                 2.2264276 
                 2.8341615 
                 −0.6077339 
               
               
                   
                   
                   
                 sulfurtransferase 
               
               
                 Rab14 
                 0.04740811 
                 ENSMUSG00000026878 
                 RAB14, 
                 −0.6071036 
                 6.0426474 
                 6.649751 
                 −0.6071036 
               
               
                   
                   
                   
                 member RAS 
               
               
                   
                   
                   
                 oncogene 
               
               
                   
                   
                   
                 family 
               
               
                 Rtkn 
                 0.04634605 
                 ENSMUSG00000034930 
                 rhotekin 
                 −0.6054473 
                 −1.9361928 
                 −1.3307455 
                 −0.6054473 
               
               
                 Gm11788 
                 0.048462883 
                 ENSMUSG00000086929 
                 predicted 
                 −0.6054473 
                 −1.9361928 
                 −1.3307455 
                 −0.6054473 
               
               
                   
                   
                   
                 gene 11788 
               
               
                 BC024978 
                 0.045672644 
                 ENSMUSG00000078786 
                 cDNA 
                 −0.605103 
                 2.6377988 
                 3.2429018 
                 −0.605103 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 BC024978 
               
               
                 Tmem86b 
                 0.042776905 
                 ENSMUSG00000045282 
                 transmembrane 
                 −0.603745 
                 0.3322961 
                 0.93604106 
                 −0.603745 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 86B 
               
               
                 2510039O18Rik 
                 0.03078932 
                 ENSMUSG00000044496 
                 RIKEN cDNA 
                 −0.601857 
                 5.210781 
                 5.812638 
                 −0.601857 
               
               
                   
                   
                   
                 2510039O18 
               
               
                   
                   
                   
                 gene 
               
               
                 Ankmy2 
                 0.038953494 
                 ENSMUSG00000036188 
                 ankyrin 
                 −0.6018472 
                 2.9531038 
                 3.554951 
                 −0.6018472 
               
               
                   
                   
                   
                 repeat and 
               
               
                   
                   
                   
                 MYND 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 2 
               
               
                 Txndc11 
                 0.026081089 
                 ENSMUSG00000022498 
                 thioredoxin 
                 −0.6013887 
                 4.539541 
                 5.1409297 
                 −0.6013887 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 11 
               
               
                 Nhp2 
                 0.047920577 
                 ENSMUSG00000001056 
                 NHP2 
                 −0.601229 
                 4.57879 
                 5.180019 
                 −0.601229 
               
               
                   
                   
                   
                 ribonucleoprotein 
               
               
                   
                   
                   
                 homolog 
               
               
                   
                   
                   
                 (yeast) 
               
               
                 Oxa1l 
                 0.044693552 
                 ENSMUSG00000000959 
                 oxidase 
                 −0.6010437 
                 4.9848366 
                 5.5858803 
                 −0.6010437 
               
               
                   
                   
                   
                 assembly 1- 
               
               
                   
                   
                   
                 like 
               
               
                 Plcb3 
                 0.040368132 
                 ENSMUSG00000024960 
                 phospholipase 
                 −0.5995494 
                 4.0962286 
                 4.695778 
                 −0.5995494 
               
               
                   
                   
                   
                 C, beta 3 
               
               
                 Mylip 
                 0.040585697 
                 ENSMUSG00000038175 
                 myosin 
                 −0.5987937 
                 2.9531038 
                 3.5518975 
                 −0.5987937 
               
               
                   
                   
                   
                 regulatory 
               
               
                   
                   
                   
                 light chain 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 protein 
               
               
                 Psmd5 
                 0.047061477 
                 ENSMUSG00000026869 
                 proteasome 
                 −0.5970666 
                 5.0473194 
                 5.644386 
                 −0.5970666 
               
               
                   
                   
                   
                 (prosome, 
               
               
                   
                   
                   
                 macropain) 
               
               
                   
                   
                   
                 26S subunit, 
               
               
                   
                   
                   
                 non-ATPase, 5 
               
               
                 Gss 
                 0.049137637 
                 ENSMUSG00000027610 
                 glutathione 
                 −0.5966295 
                 4.0922155 
                 4.688845 
                 −0.5966295 
               
               
                   
                   
                   
                 synthetase 
               
               
                 Grin1 
                 0.04237296 
                 ENSMUSG00000026959 
                 glutamate 
                 −0.5953935 
                 −2.2256994 
                 −1.6303059 
                 −0.5953935 
               
               
                   
                   
                   
                 receptor, 
               
               
                   
                   
                   
                 ionotropic, 
               
               
                   
                   
                   
                 NMDA1 (zeta 
               
               
                   
                   
                   
                 1) 
               
               
                 Rpl17 
                 0.000773 
                 ENSMUSG00000062328 
                 ribosomal 
                 −0.5925903 
                 6.0826397 
                 6.67523 
                 −0.5925903 
               
               
                   
                   
                   
                 protein L17 
               
               
                 Rab5b 
                 0.041810345 
                 ENSMUSG00000000711 
                 RAB5B, 
                 −0.5925451 
                 4.6446652 
                 5.2372103 
                 −0.5925451 
               
               
                   
                   
                   
                 member RAS 
               
               
                   
                   
                   
                 oncogene 
               
               
                   
                   
                   
                 family 
               
               
                 Kat2b 
                 0.048757337 
                 ENSMUSG00000000708 
                 K(lysine) 
                 −0.5910521 
                 3.1893382 
                 3.7803903 
                 −0.5910521 
               
               
                   
                   
                   
                 acetyltransferase 
               
               
                   
                   
                   
                 2B 
               
               
                 Rrbp1 
                 0.04895402 
                 ENSMUSG00000027422 
                 ribosome 
                 −0.5907982 
                 6.131364 
                 6.7221622 
                 −0.5907982 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 1 
               
               
                 Serpinb9b 
                 0.046480495 
                 ENSMUSG00000021403 
                 serine (or 
                 −0.5884407 
                 −1.3956243 
                 −0.8071836 
                 −0.5884407 
               
               
                   
                   
                   
                 cysteine) 
               
               
                   
                   
                   
                 peptidase 
               
               
                   
                   
                   
                 inhibitor, 
               
               
                   
                   
                   
                 clade B, 
               
               
                   
                   
                   
                 member 9b 
               
               
                 BC030307 
                 0.045264874 
                 ENSMUSG00000044937 
                 cDNA 
                 −0.5857109 
                 0.12793766 
                 0.7136486 
                 −0.5857109 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 BC030307 
               
               
                 Pcyt2 
                 0.04845 
                 ENSMUSG00000025137 
                 phosphate 
                 −0.585105 
                 4.362599 
                 4.947704 
                 −0.585105 
               
               
                   
                   
                   
                 cytidylyltransferase 
               
               
                   
                   
                   
                 2, 
               
               
                   
                   
                   
                 ethanolamine 
               
               
                 Map2k7 
                 0.047179256 
                 ENSMUSG00000002948 
                 mitogen- 
                 −0.4015106 
                 5.2838554 
                 5.685366 
                 −0.4015106 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 kinase kinase 7 
               
               
                 Fbxo33 
                 0.044220295 
                 ENSMUSG00000035329 
                 F-box protein 
                 1.066019 
                 5.693826 
                 4.627807 
                 1.066019 
               
               
                   
                   
                   
                 33 
               
               
                 Adam15 
                 0.049121536 
                 ENSMUSG00000028041 
                 a disintegrin 
                 1.1044345 
                 6.393909 
                 5.2894745 
                 1.1044345 
               
               
                   
                   
                   
                 and 
               
               
                   
                   
                   
                 metallopeptidase 
               
               
                   
                   
                   
                 domain 15 
               
               
                   
                   
                   
                 (metargidin) 
               
               
                 Slc25a33 
                 0.04958606 
                 ENSMUSG00000028982 
                 solute carrier 
                 1.1154347 
                 4.7272034 
                 3.6117687 
                 1.1154347 
               
               
                   
                   
                   
                 family 25, 
               
               
                   
                   
                   
                 member 33 
               
               
                 Lilrb4 
                 0.044434078 
                 ENSMUSG00000062593 
                 leukocyte 
                 1.1315183 
                 5.5951886 
                 4.4636703 
                 1.1315183 
               
               
                   
                   
                   
                 immunoglobulin- 
               
               
                   
                   
                   
                 like 
               
               
                   
                   
                   
                 receptor, 
               
               
                   
                   
                   
                 subfamily B, 
               
               
                   
                   
                   
                 member 4 
               
               
                 Phgdh 
                 0.043934878 
                 ENSMUSG00000053398 
                 3- 
                 1.1419146 
                 8.229285 
                 7.0873704 
                 1.1419146 
               
               
                   
                   
                   
                 phosphoglycerate 
               
               
                   
                   
                   
                 dehydrogenase 
               
               
                 Itgam 
                 0.04708623 
                 ENSMUSG00000030786 
                 integrin alpha M 
                 1.1575141 
                 6.4313216 
                 5.2738075 
                 1.1575141 
               
               
                 Papd7 
                 0.045507006 
                 ENSMUSG00000034575 
                 PAP 
                 1.1577465 
                 5.6149035 
                 4.457157 
                 1.1577465 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 7 
               
               
                 Slc2a3 
                 0.048934277 
                 ENSMUSG00000003153 
                 solute carrier 
                 1.1751518 
                 4.8415856 
                 3.6664338 
                 1.1751518 
               
               
                   
                   
                   
                 family 2 
               
               
                   
                   
                   
                 (facilitated 
               
               
                   
                   
                   
                 glucose 
               
               
                   
                   
                   
                 transporter), 
               
               
                   
                   
                   
                 member 3 
               
               
                 Rin2 
                 0.043170445 
                 ENSMUSG00000001768 
                 Ras and Rab 
                 1.2039381 
                 4.8331943 
                 3.6292562 
                 1.2039381 
               
               
                   
                   
                   
                 interactor 2 
               
               
                 Sorl1 
                 0.038947 
                 ENSMUSG00000049313 
                 sortilin- 
                 1.2207785 
                 5.069942 
                 3.8491635 
                 1.2207785 
               
               
                   
                   
                   
                 related 
               
               
                   
                   
                   
                 receptor, 
               
               
                   
                   
                   
                 LDLR class A 
               
               
                   
                   
                   
                 repeats- 
               
               
                   
                   
                   
                 containing 
               
               
                 Tlr2 
                 0.043592107 
                 ENSMUSG00000027995 
                 toll-like 
                 1.225015 
                 6.882244 
                 5.657229 
                 1.225015 
               
               
                   
                   
                   
                 receptor 2 
               
               
                 Mycn 
                 0.040442508 
                 ENSMUSG00000037169 
                 v-myc 
                 1.2253772 
                 7.345843 
                 6.1204658 
                 1.2253772 
               
               
                   
                   
                   
                 myelocytomatosis 
               
               
                   
                   
                   
                 viral 
               
               
                   
                   
                   
                 related 
               
               
                   
                   
                   
                 oncogene, 
               
               
                   
                   
                   
                 neuroblastom 
               
               
                   
                   
                   
                 a derived 
               
               
                   
                   
                   
                 (avian) 
               
               
                 Ifi203 
                 0.0450752 
                 ENSMUSG00000039997 
                 interferon 
                 1.2263527 
                 5.3914623 
                 4.1651096 
                 1.2263527 
               
               
                   
                   
                   
                 activated 
               
               
                   
                   
                   
                 gene 203 
               
               
                 Psph 
                 0.047209337 
                 ENSMUSG00000029446 
                 phosphoserine 
                 1.2327685 
                 5.4157505 
                 4.182982 
                 1.2327685 
               
               
                   
                   
                   
                 phosphatase 
               
               
                 Tcof1 
                 0.044333804 
                 ENSMUSG00000024613 
                 Treacher 
                 1.2456369 
                 6.1352696 
                 4.8896327 
                 1.2456369 
               
               
                   
                   
                   
                 Collins 
               
               
                   
                   
                   
                 Franceschetti 
               
               
                   
                   
                   
                 syndrome 1, 
               
               
                   
                   
                   
                 homolog 
               
               
                 Adar 
                 0.03601896 
                 ENSMUSG00000027951 
                 adenosine 
                 1.266367 
                 6.79049 
                 5.524123 
                 1.266367 
               
               
                   
                   
                   
                 deaminase, 
               
               
                   
                   
                   
                 RNA-specific 
               
               
                 Ogfr 
                 0.02613318 
                 ENSMUSG00000049401 
                 opioid growth 
                 1.2672534 
                 5.8403897 
                 4.5731363 
                 1.2672534 
               
               
                   
                   
                   
                 factor 
               
               
                   
                   
                   
                 receptor 
               
               
                 Nfkbid 
                 0.030824393 
                 ENSMUSG00000036931 
                 nuclear factor 
                 1.2704837 
                 5.5672717 
                 4.296788 
                 1.2704837 
               
               
                   
                   
                   
                 of kappa light 
               
               
                   
                   
                   
                 polypeptide 
               
               
                   
                   
                   
                 gene 
               
               
                   
                   
                   
                 enhancer in 
               
               
                   
                   
                   
                 B-cells 
               
               
                   
                   
                   
                 inhibitor, 
               
               
                   
                   
                   
                 delta 
               
               
                 Gm6736 
                 0.024999972 
                 ENSMUSG00000071414 
                 predicted 
                 1.2907186 
                 8.271154 
                 6.9804354 
                 1.2907186 
               
               
                   
                   
                   
                 gene 6736 
               
               
                 Fads2 
                 0.026953876 
                 ENSMUSG00000024665 
                 fatty acid 
                 1.3091817 
                 5.6204877 
                 4.311306 
                 1.3091817 
               
               
                   
                   
                   
                 desaturase 2 
               
               
                 E330016A19Rik 
                 0.042681493 
                 ENSMUSG00000032344 
                 RIKEN cDNA 
                 1.3128021 
                 4.629515 
                 3.3167129 
                 1.3128021 
               
               
                   
                   
                   
                 E330016A19 
               
               
                   
                   
                   
                 gene 
               
               
                 Bcat1 
                 0.039503414 
                 ENSMUSG00000030268 
                 branched 
                 1.3130115 
                 7.048355 
                 5.7353435 
                 1.3130115 
               
               
                   
                   
                   
                 chain 
               
               
                   
                   
                   
                 aminotransferase 
               
               
                   
                   
                   
                 1, 
               
               
                   
                   
                   
                 cytosolic 
               
               
                 Sh3bp5 
                 0.02677949 
                 ENSMUSG00000021892 
                 SH3-domain 
                 1.3191829 
                 4.8307877 
                 3.5116048 
                 1.3191829 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 5 
               
               
                   
                   
                   
                 (BTK- 
               
               
                   
                   
                   
                 associated) 
               
               
                 Ncf1 
                 0.033802066 
                 ENSMUSG00000015950 
                 neutrophil 
                 1.3297525 
                 6.17518 
                 4.8454275 
                 1.3297525 
               
               
                   
                   
                   
                 cytosolic 
               
               
                   
                   
                   
                 factor 1 
               
               
                 Clec5a 
                 0.03368596 
                 ENSMUSG00000029915 
                 C-type lectin 
                 1.3339666 
                 5.980501 
                 4.6465344 
                 1.3339666 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 family 5, 
               
               
                   
                   
                   
                 member a 
               
               
                 Tnip3 
                 0.046092596 
                 ENSMUSG00000044162 
                 TNFAIP3 
                 1.35819 
                 5.035873 
                 3.677683 
                 1.35819 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 protein 3 
               
               
                 Fam129a 
                 0.038229138 
                 ENSMUSG00000026483 
                 family with 
                 1.358445 
                 4.789251 
                 3.430806 
                 1.358445 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 similarity 129, 
               
               
                   
                   
                   
                 member A 
               
               
                 4731419I09Rik 
                 0.031881414 
                 ENSMUSG00000091513 
                 RIKEN cDNA 
                 1.3631143 
                 5.4396367 
                 4.0765224 
                 1.3631143 
               
               
                   
                   
                   
                 4731419I09 
               
               
                   
                   
                   
                 gene 
               
               
                 Stom 
                 0.028415862 
                 ENSMUSG00000026880 
                 stomatin 
                 1.386817 
                 5.465462 
                 4.078645 
                 1.386817 
               
               
                 Adam17 
                 0.012626361 
                 ENSMUSG00000052593 
                 a disintegrin 
                 1.3891568 
                 6.7518983 
                 5.3627415 
                 1.3891568 
               
               
                   
                   
                   
                 and 
               
               
                   
                   
                   
                 metallopeptidase 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 17 
               
               
                 Psat1 
                 0.047628995 
                 ENSMUSG00000024640 
                 phosphoserine 
                 1.401087 
                 8.7339 
                 7.332813 
                 1.401087 
               
               
                   
                   
                   
                 aminotransferase 1 
               
               
                 Zw10 
                 0.020814842 
                 ENSMUSG00000032264 
                 ZW10 
                 1.423672 
                 5.65898 
                 4.235308 
                 1.423672 
               
               
                   
                   
                   
                 homolog 
               
               
                   
                   
                   
                 ( Drosophila ), 
               
               
                   
                   
                   
                 centromere/kinetochore 
               
               
                   
                   
                   
                 protein 
               
               
                 Ripk2 
                 0.035168238 
                 ENSMUSG00000041135 
                 receptor 
                 1.427343 
                 4.539541 
                 3.112198 
                 1.427343 
               
               
                   
                   
                   
                 (TNFRSF)- 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 serine- 
               
               
                   
                   
                   
                 threonine 
               
               
                   
                   
                   
                 kinase 2 
               
               
                 Pcyox1l 
                 0.027063185 
                 ENSMUSG00000024579 
                 prenylcysteine 
                 1.4283414 
                 3.8186948 
                 2.3903534 
                 1.4283414 
               
               
                   
                   
                   
                 oxidase 1 
               
               
                   
                   
                   
                 like 
               
               
                 Rbpsuhrs3 
                 0.018088786 
                 ENSMUSG00000079575 
                 recombining 
                 1.4293184 
                 6.848442 
                 5.4191236 
                 1.4293184 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 suppressor of 
               
               
                   
                   
                   
                 hairless 
               
               
                   
                   
                   
                 ( Drosophila ), 
               
               
                   
                   
                   
                 related 
               
               
                   
                   
                   
                 sequence 3 
               
               
                 Cd74 
                 0.0275401 
                 ENSMUSG00000024610 
                 CD74 antigen 
                 1.4491129 
                 7.1620784 
                 5.7129655 
                 1.4491129 
               
               
                   
                   
                   
                 (invariant 
               
               
                   
                   
                   
                 polypeptide 
               
               
                   
                   
                   
                 of major 
               
               
                   
                   
                   
                 histocompatibility 
               
               
                   
                   
                   
                 complex, 
               
               
                   
                   
                   
                 class II 
               
               
                   
                   
                   
                 antigen- 
               
               
                   
                   
                   
                 associated) 
               
               
                 Clec4e 
                 0.03084233 
                 ENSMUSG00000030142 
                 C-type lectin 
                 1.4540292 
                 3.8781712 
                 2.424142 
                 1.4540292 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 family 4, 
               
               
                   
                   
                   
                 member e 
               
               
                 Sash1 
                 0.020445129 
                 ENSMUSG00000015305 
                 SAM and SH3 
                 1.4577389 
                 4.98808 
                 3.5303411 
                 1.4577389 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 1 
               
               
                 Parp12 
                 0.016752578 
                 ENSMUSG00000038507 
                 poly (ADP- 
                 1.4689444 
                 6.2917514 
                 4.822807 
                 1.4689444 
               
               
                   
                   
                   
                 ribose) 
               
               
                   
                   
                   
                 polymerase 
               
               
                   
                   
                   
                 family, 
               
               
                   
                   
                   
                 member 12 
               
               
                 Daam1 
                 0.014327282 
                 ENSMUSG00000034574 
                 dishevelled 
                 1.4692431 
                 5.6343527 
                 4.1651096 
                 1.4692431 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 activator of 
               
               
                   
                   
                   
                 morphogenesis 1 
               
               
                 Gm15645 
                 0.04660924 
                 ENSMUSG00000086414 
                 predicted 
                 1.4707485 
                 5.332296 
                 3.8615475 
                 1.4707485 
               
               
                   
                   
                   
                 gene 15645 
               
               
                 Mt2 
                 0.021577373 
                 ENSMUSG00000031762 
                 metallothionein 2 
                 1.4811826 
                 3.8851466 
                 2.403964 
                 1.4811826 
               
               
                 Slfn4 
                 0.020475224 
                 ENSMUSG00000000204 
                 schlafen 4 
                 1.4817953 
                 6.2803326 
                 4.7985373 
                 1.4817953 
               
               
                 Rbpj 
                 0.036361992 
                 ENSMUSG00000039191 
                 recombination 
                 1.4903395 
                 7.8968415 
                 6.406502 
                 1.4903395 
               
               
                   
                   
                   
                 signal 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein for 
               
               
                   
                   
                   
                 immunoglobulin 
               
               
                   
                   
                   
                 kappa J 
               
               
                   
                   
                   
                 region 
               
               
                 Ptplb 
                 0.019518027 
                 ENSMUSG00000035376 
                 protein 
                 1.4923386 
                 4.991316 
                 3.4989774 
                 1.4923386 
               
               
                   
                   
                   
                 tyrosine 
               
               
                   
                   
                   
                 phosphatase- 
               
               
                   
                   
                   
                 like (proline 
               
               
                   
                   
                   
                 instead of 
               
               
                   
                   
                   
                 catalytic 
               
               
                   
                   
                   
                 arginine), 
               
               
                   
                   
                   
                 member b 
               
               
                 Asph 
                 0.026277151 
                 ENSMUSG00000028207 
                 aspartate- 
                 1.4966014 
                 7.1630354 
                 5.666434 
                 1.4966014 
               
               
                   
                   
                   
                 beta- 
               
               
                   
                   
                   
                 hydroxylase 
               
               
                 Spata13 
                 0.01995978 
                 ENSMUSG00000021990 
                 spermatogenesis 
                 1.500841 
                 5.070962 
                 3.570121 
                 1.500841 
               
               
                   
                   
                   
                 associated 13 
               
               
                 Gp49a 
                 0.01797235 
                 ENSMUSG00000089672 
                 glycoprotein 
                 1.52455 
                 5.52696 
                 4.00241 
                 1.52455 
               
               
                   
                   
                   
                 49 A 
               
               
                 Glrx 
                 0.020311931 
                 ENSMUSG00000021591 
                 glutaredoxin 
                 1.5271039 
                 3.8758385 
                 2.3487346 
                 1.5271039 
               
               
                 Slc6a4 
                 0.015190769 
                 ENSMUSG00000020838 
                 solute carrier 
                 1.5354503 
                 6.4502573 
                 4.914807 
                 1.5354503 
               
               
                   
                   
                   
                 family 6 
               
               
                   
                   
                   
                 (neurotransmitter 
               
               
                   
                   
                   
                 transporter, 
               
               
                   
                   
                   
                 serotonin), 
               
               
                   
                   
                   
                 member 4 
               
               
                 Setdb2 
                 0.023574898 
                 ENSMUSG00000071350 
                 SET domain, 
                 1.5376244 
                 4.5600257 
                 3.0224013 
                 1.5376244 
               
               
                   
                   
                   
                 bifurcated 2 
               
               
                 Eif2ak2 
                 0.00837484 
                 ENSMUSG00000024079 
                 eukaryotic 
                 1.551614 
                 6.850225 
                 5.298611 
                 1.551614 
               
               
                   
                   
                   
                 translation 
               
               
                   
                   
                   
                 initiation 
               
               
                   
                   
                   
                 factor 2-alpha 
               
               
                   
                   
                   
                 kinase 2 
               
               
                 Stat2 
                 0.022812009 
                 ENSMUSG00000040033 
                 signal 
                 1.5807465 
                 4.598729 
                 3.0179825 
                 1.5807465 
               
               
                   
                   
                   
                 transducer 
               
               
                   
                   
                   
                 and activator 
               
               
                   
                   
                   
                 of 
               
               
                   
                   
                   
                 transcription 2 
               
               
                 Herpud1 
                 0.009253571 
                 ENSMUSG00000031770 
                 homocysteine- 
                 1.58482 
                 5.684527 
                 4.099707 
                 1.58482 
               
               
                   
                   
                   
                 inducible, 
               
               
                   
                   
                   
                 endoplasmic 
               
               
                   
                   
                   
                 reticulum 
               
               
                   
                   
                   
                 stress- 
               
               
                   
                   
                   
                 inducible, 
               
               
                   
                   
                   
                 ubiquitin-like 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 member 1 
               
               
                 Tmem2 
                 0.01044533 
                 ENSMUSG00000024754 
                 transmembrane 
                 1.585879 
                 6.534744 
                 4.948865 
                 1.585879 
               
               
                   
                   
                   
                 protein 2 
               
               
                 Bmf 
                 0.03913493 
                 ENSMUSG00000040093 
                 BCL2 
                 1.6214382 
                 4.1298966 
                 2.5084584 
                 1.6214382 
               
               
                   
                   
                   
                 modifying 
               
               
                   
                   
                   
                 factor 
               
               
                 Mitd1 
                 0.020194989 
                 ENSMUSG00000026088 
                 MIT, 
                 1.6276122 
                 4.689184 
                 3.0615718 
                 1.6276122 
               
               
                   
                   
                   
                 microtubule 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 and 
               
               
                   
                   
                   
                 transport, 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 1 
               
               
                 Slfn3 
                 0.017630316 
                 ENSMUSG00000018986 
                 schlafen 3 
                 1.6345547 
                 4.6744967 
                 3.039942 
                 1.6345547 
               
               
                 Tasp1 
                 0.017170591 
                 ENSMUSG00000039033 
                 taspase, 
                 1.6429404 
                 4.678517 
                 3.0355766 
                 1.6429404 
               
               
                   
                   
                   
                 threonine 
               
               
                   
                   
                   
                 aspartase 1 
               
               
                 Ifi35 
                 0.013708029 
                 ENSMUSG00000010358 
                 interferon- 
                 1.6526694 
                 3.8688183 
                 2.2161489 
                 1.6526694 
               
               
                   
                   
                   
                 induced 
               
               
                   
                   
                   
                 protein 35 
               
               
                 Slc11a1 
                 0.002501 
                 ENSMUSG00000026177 
                 solute carrier 
                 1.6735306 
                 5.9848366 
                 4.311306 
                 1.6735306 
               
               
                   
                   
                   
                 family 11 
               
               
                   
                   
                   
                 (proton- 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 divalent 
               
               
                   
                   
                   
                 metal ion 
               
               
                   
                   
                   
                 transporters), 
               
               
                   
                   
                   
                 member 1 
               
               
                 Ssh2 
                 0.012622531 
                 ENSMUSG00000037926 
                 slingshot 
                 1.691286 
                 5.652862 
                 3.961576 
                 1.691286 
               
               
                   
                   
                   
                 homolog 2 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Parp10 
                 0.015827406 
                 ENSMUSG00000063268 
                 poly (ADP- 
                 1.6941132 
                 4.7076635 
                 3.0135503 
                 1.6941132 
               
               
                   
                   
                   
                 ribose) 
               
               
                   
                   
                   
                 polymerase 
               
               
                   
                   
                   
                 family, 
               
               
                   
                   
                   
                 member 10 
               
               
                 Uba7 
                 0.016567297 
                 ENSMUSG00000032596 
                 ubiquitin-like 
                 1.7041156 
                 4.98808 
                 3.2839644 
                 1.7041156 
               
               
                   
                   
                   
                 modifier 
               
               
                   
                   
                   
                 activating 
               
               
                   
                   
                   
                 enzyme 7 
               
               
                 Fam49a 
                 0.014623731 
                 ENSMUSG00000020589 
                 family with 
                 1.7116549 
                 4.9956193 
                 3.2839644 
                 1.7116549 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 similarity 49, 
               
               
                   
                   
                   
                 member A 
               
               
                 Dennd2d 
                 0.031796068 
                 ENSMUSG00000027901 
                 DENN/MADD 
                 1.7250655 
                 4.427743 
                 2.7026775 
                 1.7250655 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 2D 
               
               
                 Pld4 
                 0.015250916 
                 ENSMUSG00000052160 
                 phospholipase 
                 1.7269177 
                 5.590929 
                 3.8640113 
                 1.7269177 
               
               
                   
                   
                   
                 D family, 
               
               
                   
                   
                   
                 member 4 
               
               
                 Fosl1 
                 0.03473085 
                 ENSMUSG00000024912 
                 fos-like 
                 1.7354727 
                 3.2873702 
                 1.5518975 
                 1.7354727 
               
               
                   
                   
                   
                 antigen 1 
               
               
                 Ugcg 
                 0.015557361 
                 ENSMUSG00000028381 
                 UDP-glucose 
                 1.7373785 
                 4.746483 
                 3.0091045 
                 1.7373785 
               
               
                   
                   
                   
                 ceramide 
               
               
                   
                   
                   
                 glucosyltransferase 
               
               
                 Slc7a5 
                 0.014336524 
                 ENSMUSG00000040010 
                 solute carrier 
                 1.7564154 
                 7.282095 
                 5.5256796 
                 1.7564154 
               
               
                   
                   
                   
                 family 7 
               
               
                   
                   
                   
                 (cationic 
               
               
                   
                   
                   
                 amino acid 
               
               
                   
                   
                   
                 transporter, 
               
               
                   
                   
                   
                 y+ system), 
               
               
                   
                   
                   
                 member 5 
               
               
                 Odc1 
                 0.003826073 
                 ENSMUSG00000011179 
                 ornithine 
                 1.7847224 
                 8.635129 
                 6.8504066 
                 1.7847224 
               
               
                   
                   
                   
                 decarboxylase, 
               
               
                   
                   
                   
                 structural 1 
               
               
                 Gch1 
                 0.032283947 
                 ENSMUSG00000037580 
                 GTP 
                 1.7982392 
                 3.3254747 
                 1.5272355 
                 1.7982392 
               
               
                   
                   
                   
                 cyclohydrolase 1 
               
               
                 Slc6a9 
                 0.012537855 
                 ENSMUSG00000028542 
                 solute carrier 
                 1.8009172 
                 4.5629287 
                 2.7620115 
                 1.8009172 
               
               
                   
                   
                   
                 family 6 
               
               
                   
                   
                   
                 (neurotransmitter 
               
               
                   
                   
                   
                 transporter, 
               
               
                   
                   
                   
                 glycine), 
               
               
                   
                   
                   
                 member 9 
               
               
                 Phf15 
                 0.006952753 
                 ENSMUSG00000020387 
                 PHD finger 
                 1.803466 
                 6.181804 
                 4.378338 
                 1.803466 
               
               
                   
                   
                   
                 protein 15 
               
               
                 Gpr179 
                 0.027233575 
                 ENSMUSG00000070337 
                 G protein- 
                 1.812993 
                 3.749034 
                 1.936041 
                 1.812993 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 receptor 179 
               
               
                 Sp110 
                 0.008639846 
                 ENSMUSG00000070034 
                 Sp110 
                 1.8445542 
                 4.076051 
                 2.2314968 
                 1.8445542 
               
               
                   
                   
                   
                 nuclear body 
               
               
                   
                   
                   
                 protein 
               
               
                 Tpst1 
                 0.032691307 
                 ENSMUSG00000034118 
                 protein- 
                 1.8491342 
                 4.3575926 
                 2.5084584 
                 1.8491342 
               
               
                   
                   
                   
                 tyrosine 
               
               
                   
                   
                   
                 sulfotransferase 1 
               
               
                 Qsox1 
                 0.007972689 
                 ENSMUSG00000033684 
                 quiescin Q6 
                 1.8776744 
                 4.7805486 
                 2.9028742 
                 1.8776744 
               
               
                   
                   
                   
                 sulfhydryl 
               
               
                   
                   
                   
                 oxidase 1 
               
               
                 Ier3 
                 0.014196688 
                 ENSMUSG00000003541 
                 immediate 
                 1.890267 
                 4.981586 
                 3.091319 
                 1.890267 
               
               
                   
                   
                   
                 early 
               
               
                   
                   
                   
                 response 3 
               
               
                 Ets2 
                 0.006089266 
                 ENSMUSG00000022895 
                 E26 avian 
                 1.8925752 
                 5.7541227 
                 3.8615475 
                 1.8925752 
               
               
                   
                   
                   
                 leukemia 
               
               
                   
                   
                   
                 oncogene 2, 
               
               
                   
                   
                   
                 3′ domain 
               
               
                 Zc3h12c 
                 0.004831877 
                 ENSMUSG00000035164 
                 zinc finger 
                 1.8958522 
                 6.226885 
                 4.3310328 
                 1.8958522 
               
               
                   
                   
                   
                 CCCH type 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 12C 
               
               
                 Ccdc24 
                 0.030835103 
                 ENSMUSG00000078588 
                 coiled-coil 
                 1.8994296 
                 3.6239665 
                 1.7245369 
                 1.8994296 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 24 
               
               
                 Plk2 
                 0.008188616 
                 ENSMUSG00000021701 
                 polo-like 
                 1.9049172 
                 5.0740175 
                 3.1691003 
                 1.9049172 
               
               
                   
                   
                   
                 kinase 2 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Stat1 
                 0.007773834 
                 ENSMUSG00000026104 
                 signal 
                 1.9285366 
                 5.6984534 
                 3.7699168 
                 1.9285366 
               
               
                   
                   
                   
                 transducer 
               
               
                   
                   
                   
                 and activator 
               
               
                   
                   
                   
                 of 
               
               
                   
                   
                   
                 transcription 1 
               
               
                 Chac1 
                 0.031882036 
                 ENSMUSG00000027313 
                 ChaC, cation 
                 1.9297678 
                 3.6758378 
                 1.74607 
                 1.9297678 
               
               
                   
                   
                   
                 transport 
               
               
                   
                   
                   
                 regulator-like 
               
               
                   
                   
                   
                 1 ( E. coli ) 
               
               
                 Gng2 
                 0.035535995 
                 ENSMUSG00000043004 
                 guanine 
                 1.9435497 
                 3.6128042 
                 1.6692545 
                 1.9435497 
               
               
                   
                   
                   
                 nucleotide 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein (G 
               
               
                   
                   
                   
                 protein), 
               
               
                   
                   
                   
                 gamma 2 
               
               
                 Grap 
                 0.003583301 
                 ENSMUSG00000004837 
                 GRB2-related 
                 1.9460665 
                 6.5101385 
                 4.564072 
                 1.9460665 
               
               
                   
                   
                   
                 adaptor 
               
               
                   
                   
                   
                 protein 
               
               
                 Pycr1 
                 0.025833854 
                 ENSMUSG00000025140 
                 pyrroline-5- 
                 1.95558527 
                 2.7541227 
                 0.79853743 
                 1.95558527 
               
               
                   
                   
                   
                 carboxylate 
               
               
                   
                   
                   
                 reductase 1 
               
               
                 Trim12c 
                 0.012106774 
                 ENSMUSG00000057143 
                 tripartite 
                 1.9593374 
                 4.2135544 
                 2.254217 
                 1.9593374 
               
               
                   
                   
                   
                 motif- 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 12C 
               
               
                 Clec4d 
                 0.007304858 
                 ENSMUSG00000030144 
                 C-type lectin 
                 1.9701681 
                 4.1551223 
                 2.1849542 
                 1.9701681 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 family 4, 
               
               
                   
                   
                   
                 member d 
               
               
                 Cpd 
                 0.002164662 
                 ENSMUSG00000020841 
                 carboxypeptidase D 
                 1.990618 
                 8.797824 
                 6.807206 
                 1.990618 
               
               
                 Dtx3l 
                 0.002565308 
                 ENSMUSG00000049502 
                 deltex 3-like 
                 2.010299 
                 5.4739695 
                 3.4636705 
                 2.010299 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Car12 
                 0.015473221 
                 ENSMUSG00000032373 
                 carbonic 
                 2.0304694 
                 4.0306406 
                 2.0001712 
                 2.0304694 
               
               
                   
                   
                   
                 anyhydrase 
               
               
                   
                   
                   
                 12 
               
               
                 Lrrc17 
                 0.006864152 
                 ENSMUSG00000039883 
                 leucine rich 
                 2.038969 
                 5.394724 
                 3.355755 
                 2.038969 
               
               
                   
                   
                   
                 repeat 
               
               
                   
                   
                   
                 containing 17 
               
               
                 Gm17549 
                 0.002010584 
                 ENSMUSG00000091543 
                 predicted 
                 2.0470712 
                 5.278568 
                 3.2314968 
                 2.0470712 
               
               
                   
                   
                   
                 gene, 17549 
               
               
                 Fyb 
                 0.001659938 
                 ENSMUSG00000022148 
                 FYN binding 
                 2.0631156 
                 6.3173323 
                 4.2542167 
                 2.0631156 
               
               
                   
                   
                   
                 protein 
               
               
                 Ccl3 
                 0.003072253 
                 ENSMUSG00000000982 
                 chemokine 
                 2.0781493 
                 7.3361187 
                 5.2579694 
                 2.0781493 
               
               
                   
                   
                   
                 (C-C motif) 
               
               
                   
                   
                   
                 ligand 3 
               
               
                 Trim5 
                 0.028752334 
                 ENSMUSG00000060441 
                 tripartite 
                 2.0891548 
                 2.9081564 
                 0.8190016 
                 2.0891548 
               
               
                   
                   
                   
                 motif- 
               
               
                   
                   
                   
                 containing 5 
               
               
                 Dusp2 
                 0.001119755 
                 ENSMUSG00000027368 
                 dual 
                 2.097596 
                 6.005255 
                 3.907659 
                 2.097596 
               
               
                   
                   
                   
                 specificity 
               
               
                   
                   
                   
                 phosphatase 2 
               
               
                 Lyz1 
                 0.001480785 
                 ENSMUSG00000069515 
                 lysozyme 1 
                 2.1054833 
                 5.294374 
                 3.1888907 
                 2.1054833 
               
               
                 Dhrs3 
                 0.002936547 
                 ENSMUSG00000066026 
                 dehydrogenase/ 
                 2.1068875 
                 4.804048 
                 2.6971605 
                 2.1068875 
               
               
                   
                   
                   
                 reductase 
               
               
                   
                   
                   
                 (SDR family) 
               
               
                   
                   
                   
                 member 3 
               
               
                 Slc1a4 
                 0.00929272 
                 ENSMUSG00000020142 
                 solute carrier 
                 2.1085265 
                 4.301343 
                 2.1928165 
                 2.1085265 
               
               
                   
                   
                   
                 family 1 
               
               
                   
                   
                   
                 (glutamate/neutral 
               
               
                   
                   
                   
                 amino 
               
               
                   
                   
                   
                 acid 
               
               
                   
                   
                   
                 transporter), 
               
               
                   
                   
                   
                 member 4 
               
               
                 Epsti1 
                 0.044788834 
                 ENSMUSG00000022014 
                 epithelial 
                 2.11605915 
                 2.6432946 
                 0.52723545 
                 2.11605915 
               
               
                   
                   
                   
                 stromal 
               
               
                   
                   
                   
                 interaction 1 
               
               
                   
                   
                   
                 (breast) 
               
               
                 H2-T24 
                 0.001531115 
                 ENSMUSG00000053835 
                 histocompatibility 
                 2.1219106 
                 5.3534074 
                 3.2314968 
                 2.1219106 
               
               
                   
                   
                   
                 2, T 
               
               
                   
                   
                   
                 region locus 
               
               
                   
                   
                   
                 24 
               
               
                 Zc3h12a 
                 0.001478526 
                 ENSMUSG00000042677 
                 zinc finger 
                 2.1227481 
                 4.1318526 
                 2.0091045 
                 2.1227481 
               
               
                   
                   
                   
                 CCCH type 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 12A 
               
               
                 Sass6 
                 0.001012042 
                 ENSMUSG00000027959 
                 spindle 
                 2.123662 
                 6.059703 
                 3.936041 
                 2.123662 
               
               
                   
                   
                   
                 assembly 6 
               
               
                   
                   
                   
                 homolog ( C. elegans ) 
               
               
                 Abcc4 
                 0.007724259 
                 ENSMUSG00000032849 
                 ATP-binding 
                 2.1336435 
                 5.597314 
                 3.4636705 
                 2.1336435 
               
               
                   
                   
                   
                 cassette, sub- 
               
               
                   
                   
                   
                 family C 
               
               
                   
                   
                   
                 (CFTR/MRP), 
               
               
                   
                   
                   
                 member 4 
               
               
                 Mef2c 
                 0.000477217 
                 ENSMUSG00000005583 
                 myocyte 
                 2.1434676 
                 6.121061 
                 3.9775934 
                 2.1434676 
               
               
                   
                   
                   
                 enhancer 
               
               
                   
                   
                   
                 factor 2C 
               
               
                 Mpeg1 
                 0.000799983 
                 ENSMUSG00000046805 
                 macrophage 
                 2.1497637 
                 6.5332637 
                 4.3835 
                 2.1497637 
               
               
                   
                   
                   
                 expressed 
               
               
                   
                   
                   
                 gene 1 
               
               
                 Rnf213 
                 0.007161953 
                 ENSMUSG00000070327 
                 ring finger 
                 2.15004 
                 10.065887 
                 7.915847 
                 2.15004 
               
               
                   
                   
                   
                 protein 213 
               
               
                 Dusp5 
                 0.009104466 
                 ENSMUSG00000034765 
                 dual 
                 2.1525025 
                 3.5082576 
                 1.3557551 
                 2.1525025 
               
               
                   
                   
                   
                 specificity 
               
               
                   
                   
                   
                 phosphatase 5 
               
               
                 Irf9 
                 0.008142755 
                 ENSMUSG00000002325 
                 interferon 
                 2.1531142 
                 5.075034 
                 2.9219198 
                 2.1531142 
               
               
                   
                   
                   
                 regulatory 
               
               
                   
                   
                   
                 factor 9 
               
               
                 Tlr9 
                 0.007655328 
                 ENSMUSG00000045322 
                 toll-like 
                 2.1671071 
                 4.3441563 
                 2.1770492 
                 2.1671071 
               
               
                   
                   
                   
                 receptor 9 
               
               
                 Rapgef5 
                 0.018954162 
                 ENSMUSG00000041992 
                 Rap guanine 
                 2.177482 
                 3.789251 
                 1.611769 
                 2.177482 
               
               
                   
                   
                   
                 nucleotide 
               
               
                   
                   
                   
                 exchange 
               
               
                   
                   
                   
                 factor (GEF) 5 
               
               
                 Akap5 
                 0.001063172 
                 ENSMUSG000000021057 
                 A kinase 
                 2.202505 
                 5.302212 
                 3.099707 
                 2.202505 
               
               
                   
                   
                   
                 (PRKA) 
               
               
                   
                   
                   
                 anchor 
               
               
                   
                   
                   
                 protein 5 
               
               
                 Serpine1 
                 0.005375954 
                 ENSMUSG000000037411 
                 serine (or 
                 2.204582 
                 5.140623 
                 2.936041 
                 2.204582 
               
               
                   
                   
                   
                 cysteine) 
               
               
                   
                   
                   
                 peptidase 
               
               
                   
                   
                   
                 inhibitor, 
               
               
                   
                   
                   
                 clade E, 
               
               
                   
                   
                   
                 member 1 
               
               
                 Xylt2 
                 0.003379382 
                 ENSMUSG000000020868 
                 xylosyltransferase 
                 2.2256849 
                 5.0190606 
                 2.7933757 
                 2.2256849 
               
               
                   
                   
                   
                 II 
               
               
                 Sash3 
                 0.000824317 
                 ENSMUSG000000031101 
                 SAM and SH3 
                 2.2435947 
                 6.8015924 
                 4.5579977 
                 2.2435947 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 3 
               
               
                 B4galt6 
                 0.0185172 
                 ENSMUSG000000056124 
                 UDP- 
                 2.2701052 
                 3.7207193 
                 1.4506141 
                 2.2701052 
               
               
                   
                   
                   
                 Gal:betaGlcNAc 
               
               
                   
                   
                   
                 beta 1,4- 
               
               
                   
                   
                   
                 galactosyltransferase, 
               
               
                   
                   
                   
                 polypeptide 6 
               
               
                 Herc6 
                 0.012329049 
                 ENSMUSG000000029798 
                 hect domain 
                 2.2897381 
                 3.543955 
                 1.2542169 
                 2.2897381 
               
               
                   
                   
                   
                 and RLD 6 
               
               
                 Lgals3bp 
                 0.001605042 
                 ENSMUSG000000033880 
                 lectin, 
                 2.3190542 
                 5.550551 
                 3.2314968 
                 2.3190542 
               
               
                   
                   
                   
                 galactoside- 
               
               
                   
                   
                   
                 binding, 
               
               
                   
                   
                   
                 soluble, 3 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 
               
               
                 Slfn5 
                 0.001191921 
                 ENSMUSG000000054404 
                 schlafen 5 
                 2.3321457 
                 5.6738253 
                 3.3416796 
                 2.3321457 
               
               
                 Cd52 
                 0.035810307 
                 ENSMUSG000000000682 
                 CD52 antigen 
                 2.3386994 
                 3.3117347 
                 0.9730353 
                 2.3386994 
               
               
                 Ggta1 
                 0.019090641 
                 ENSMUSG000000035778 
                 glycoprotein 
                 2.3622925 
                 3.8259628 
                 1.4636703 
                 2.3622925 
               
               
                   
                   
                   
                 galactosyltransferase 
               
               
                   
                   
                   
                 alpha 
               
               
                   
                   
                   
                 1, 3 
               
               
                 Tlr7 
                 0.02658981 
                 ENSMUSG000000044583 
                 toll-like 
                 2.37990606 
                 2.804048 
                 0.42414194 
                 2.37990606 
               
               
                   
                   
                   
                 receptor 7 
               
               
                 Fli1 
                 0.007515412 
                 ENSMUSG000000016087 
                 Friend 
                 2.3803927 
                 3.9685104 
                 1.5881177 
                 2.3803927 
               
               
                   
                   
                   
                 leukemia 
               
               
                   
                   
                   
                 integration 1 
               
               
                 Oasl1 
                 0.000525786 
                 ENSMUSG000000041827 
                 2′-5′ 
                 2.3906102 
                 7.1178565 
                 4.7272463 
                 2.3906102 
               
               
                   
                   
                   
                 oligoadenylate 
               
               
                   
                   
                   
                 synthetase- 
               
               
                   
                   
                   
                 like 1 
               
               
                 Mndal 
                 0.004260393 
                 ENSMUSG000000090272 
                 myeloid 
                 2.3974011 
                 4.5902176 
                 2.1928165 
                 2.3974011 
               
               
                   
                   
                   
                 nuclear 
               
               
                   
                   
                   
                 differentiation 
               
               
                   
                   
                   
                 antigen like 
               
               
                 Gas7 
                 0.000438789 
                 ENSMUSG000000033066 
                 growth arrest 
                 2.4181176 
                 7.49464 
                 5.0765224 
                 2.4181176 
               
               
                   
                   
                   
                 specific 7 
               
               
                 Stab1 
                 0.031446114 
                 ENSMUSG000000042286 
                 stabilin 1 
                 2.4637601 
                 3.342468 
                 0.8787079 
                 2.4637601 
               
               
                 Lck 
                 0.008432007 
                 ENSMUSG000000000409 
                 lymphocyte 
                 2.47206192 
                 2.9486713 
                 0.47660938 
                 2.47206192 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 tyrosine 
               
               
                   
                   
                   
                 kinase 
               
               
                 Pdcd1 
                 0.024454752 
                 ENSMUSG000000026285 
                 programmed 
                 2.47214922 
                 2.813829 
                 0.34167978 
                 2.47214922 
               
               
                   
                   
                   
                 cell death 1 
               
               
                 Otub2 
                 0.03326988 
                 ENSMUSG000000021203 
                 OTU domain, 
                 2.47428 
                 3.1435344 
                 0.6692544 
                 2.47428 
               
               
                   
                   
                   
                 ubiquitin 
               
               
                   
                   
                   
                 aldehyde 
               
               
                   
                   
                   
                 binding 2 
               
               
                 Tanc2 
                 0.03190521 
                 ENSMUSG000000053580 
                 tetratricopeptide 
                 2.50528675 
                 2.789251 
                 0.28396425 
                 2.50528675 
               
               
                   
                   
                   
                 repeat, 
               
               
                   
                   
                   
                 ankyrin 
               
               
                   
                   
                   
                 repeat and 
               
               
                   
                   
                   
                 coiled-coil 
               
               
                   
                   
                   
                 containing 2 
               
               
                 Gm7676 
                 0.042453267 
                 ENSMUSG000000068631 
                 predicted 
                 2.54145726 
                 3.2768009 
                 0.73534364 
                 2.54145726 
               
               
                   
                   
                   
                 gene 7676 
               
               
                 Cp 
                 0.039974507 
                 ENSMUSG000000003617 
                 ceruloplasmin 
                 2.5422796 
                 2.6377988 
                 0.0955192 
                 2.5422796 
               
               
                 Pck2 
                 0.000345685 
                 ENSMUSG000000040618 
                 phosphoenol 
                 2.5555408 
                 5.9458942 
                 3.3903534 
                 2.5555408 
               
               
                   
                   
                   
                 pyruvate 
               
               
                   
                   
                   
                 carboxykinase 2 
               
               
                   
                   
                   
                 (mitochondrial) 
               
               
                 Lyl1 
                 0.011417538 
                 ENSMUSG00000034041 
                 lymphoblastomic 
                 2.5561529 
                 3.5291882 
                 0.9730353 
                 2.5561529 
               
               
                   
                   
                   
                 leukemia 1 
               
               
                 BC006779 
                 0.000513289 
                 ENSMUSG00000027580 
                 cDNA 
                 2.5614315 
                 6.8995705 
                 4.338139 
                 2.5614315 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 BC006779 
               
               
                 Dab2 
                 0.0005445 
                 ENSMUSG00000022150 
                 disabled 
                 2.5665724 
                 5.390645 
                 2.8240726 
                 2.5665724 
               
               
                   
                   
                   
                 homolog 2 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Cd36 
                 0.000197919 
                 ENSMUSG00000002944 
                 CD36 antigen 
                 2.5687684 
                 7.523425 
                 4.9546566 
                 2.5687684 
               
               
                 Gm885 
                 0.000151064 
                 ENSMUSG00000040528 
                 predicted 
                 2.5931254 
                 4.3709044 
                 1.777779 
                 2.5931254 
               
               
                   
                   
                   
                 gene 885 
               
               
                 Cxcl16 
                 0.040038653 
                 ENSMUSG00000018920 
                 chemokine 
                 2.617381 
                 2.7129002 
                 0.0955192 
                 2.617381 
               
               
                   
                   
                   
                 (C—X—C motif) 
               
               
                   
                   
                   
                 ligand 16 
               
               
                 Samd9l 
                 0.001224701 
                 ENSMUSG00000047735 
                 sterile alpha 
                 2.6175766 
                 5.347527 
                 2.7299504 
                 2.6175766 
               
               
                   
                   
                   
                 motif domain 
               
               
                   
                   
                   
                 containing 9- 
               
               
                   
                   
                   
                 like 
               
               
                 Ifitm3 
                 0.000167685 
                 ENSMUSG00000025492 
                 interferon 
                 2.6401358 
                 7.2650404 
                 4.6249046 
                 2.6401358 
               
               
                   
                   
                   
                 induced 
               
               
                   
                   
                   
                 transmembrane 
               
               
                   
                   
                   
                 protein 3 
               
               
                 Tlr1 
                 0.000515847 
                 ENSMUSG00000044827 
                 toll-like 
                 2.644155 
                 4.99991 
                 2.355755 
                 2.644155 
               
               
                   
                   
                   
                 receptor 1 
               
               
                 Icosl 
                 0.0499492 
                 ENSMUSG00000000732 
                 icos ligand 
                 2.6630416 
                 0.3322961 
                 −2.3307455 
                 2.6630416 
               
               
                 5730469M10Rik 
                 0.008745185 
                 ENSMUSG00000021792 
                 RIKEN cDNA 
                 2.6663043 
                 3.979415 
                 1.3131107 
                 2.6663043 
               
               
                   
                   
                   
                 5730469M10 
               
               
                   
                   
                   
                 gene 
               
               
                 Oas1a 
                 5.18934E−06 
                 ENSMUSG00000052776 
                 2′-5′ 
                 2.6766694 
                 6.7122464 
                 4.035577 
                 2.6766694 
               
               
                   
                   
                   
                 oligoadenylate 
               
               
                   
                   
                   
                 synthetase 
               
               
                   
                   
                   
                 1A 
               
               
                 Prss16 
                 0.029725667 
                 ENSMUSG00000006179 
                 protease, 
                 2.73307769 
                 2.8617637 
                 0.12868601 
                 2.73307769 
               
               
                   
                   
                   
                 serine, 16 
               
               
                   
                   
                   
                 (thymus) 
               
               
                 Pla2g5 
                 0.044189025 
                 ENSMUSG00000041193 
                 phospholipase 
                 2.73704227 
                 2.6542242 
                 −0.0828181 
                 2.73704227 
               
               
                   
                   
                   
                 A2, group V 
               
               
                 Pros1 
                 0.044148285 
                 ENSMUSG00000022912 
                 protein S 
                 2.74788957 
                 2.6650715 
                 −0.0828181 
                 2.74788957 
               
               
                   
                   
                   
                 (alpha) 
               
               
                 Gm4902 
                 0.038773473 
                 ENSMUSG00000091649 
                 predicted 
                 2.75766276 
                 2.1818047 
                 −0.5758581 
                 2.75766276 
               
               
                   
                   
                   
                 gene 4902 
               
               
                 Ptgs2 
                 0.000652096 
                 ENSMUSG00000032487 
                 prostaglandin- 
                 2.7881889 
                 4.6071906 
                 1.8190017 
                 2.7881889 
               
               
                   
                   
                   
                 endoperoxide 
               
               
                   
                   
                   
                 synthase 2 
               
               
                 D330045A20Rik 
                 0.03840468 
                 ENSMUSG00000042498 
                 RIKEN cDNA 
                 2.82533312 
                 2.3525686 
                 −0.4727645 
                 2.82533312 
               
               
                   
                   
                   
                 D330045A20 
               
               
                   
                   
                   
                 gene 
               
               
                 Gbp7 
                 0.001749768 
                 ENSMUSG00000040253 
                 guanylate 
                 2.8321975 
                 4.384095 
                 1.5518975 
                 2.8321975 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 7 
               
               
                 Abcc3 
                 0.04643164 
                 ENSMUSG00000020865 
                 ATP-binding 
                 2.83324138 
                 2.54689 
                 −0.2863514 
                 2.83324138 
               
               
                   
                   
                   
                 cassette, sub- 
               
               
                   
                   
                   
                 family C 
               
               
                   
                   
                   
                 (CFTR/MRP), 
               
               
                   
                   
                   
                 member 3 
               
               
                 Lsp1 
                 0.006437104 
                 ENSMUSG00000018819 
                 lymphocyte 
                 2.8433657 
                 3.6623673 
                 0.8190016 
                 2.8433657 
               
               
                   
                   
                   
                 specific 1 
               
               
                 Fads6 
                 0.03632363 
                 ENSMUSG00000044788 
                 fatty acid 
                 2.85568675 
                 2.3322961 
                 −0.5233907 
                 2.85568675 
               
               
                   
                   
                   
                 desaturase 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 family, 
               
               
                   
                   
                   
                 member 6 
               
               
                 Dlg4 
                 0.015582533 
                 ENSMUSG00000020886 
                 discs, large 
                 2.8627704 
                 2.0555868 
                 −0.8071836 
                 2.8627704 
               
               
                   
                   
                   
                 homolog 4 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Spire2 
                 0.04822587 
                 ENSMUSG00000010154 
                 spire 
                 2.86800703 
                 0.99669313 
                 −1.8713139 
                 2.86800703 
               
               
                   
                   
                   
                 homolog 2 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Parp9 
                 3.87374E−05 
                 ENSMUSG00000022906 
                 poly (ADP- 
                 2.8685094 
                 5.217244 
                 2.3487346 
                 2.8685094 
               
               
                   
                   
                   
                 ribose) 
               
               
                   
                   
                   
                 polymerase 
               
               
                   
                   
                   
                 family, 
               
               
                   
                   
                   
                 member 9 
               
               
                 Spred3 
                 0.020723633 
                 ENSMUSG00000037239 
                 sprouty- 
                 2.8737209 
                 2.1279378 
                 −0.7457831 
                 2.8737209 
               
               
                   
                   
                   
                 related, EVH1 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 3 
               
               
                 Oas1c 
                 0.04526947 
                 ENSMUSG00000001166 
                 2′-5′ 
                 2.8841373 
                 1.7233167 
                 −1.1608206 
                 2.8841373 
               
               
                   
                   
                   
                 oligoadenylate 
               
               
                   
                   
                   
                 synthetase 
               
               
                   
                   
                   
                 1C 
               
               
                 Procr 
                 0.029140951 
                 ENSMUSG00000027611 
                 protein C 
                 2.886866 
                 1.804048 
                 −1.082818 
                 2.886866 
               
               
                   
                   
                   
                 receptor, 
               
               
                   
                   
                   
                 endothelial 
               
               
                 Plek 
                 0.000116704 
                 ENSMUSG00000020120 
                 pleckstrin 
                 2.9145183 
                 7.8633833 
                 4.948865 
                 2.9145183 
               
               
                 Soat2 
                 0.04084924 
                 ENSMUSG00000023045 
                 sterol O- 
                 2.91756277 
                 2.5410135 
                 −0.3765493 
                 2.91756277 
               
               
                   
                   
                   
                 acyltransferase 2 
               
               
                 Bst2 
                 0.000290517 
                 ENSMUSG00000046718 
                 bone marrow 
                 2.9644963 
                 5.522494 
                 2.5579977 
                 2.9644963 
               
               
                   
                   
                   
                 stromal cell 
               
               
                   
                   
                   
                 antigen 2 
               
               
                 Oas1g 
                 4.99617E−06 
                 ENSMUSG00000066861 
                 2′-5′ 
                 2.9733734 
                 6.706023 
                 3.7326496 
                 2.9733734 
               
               
                   
                   
                   
                 oligoadenylate 
               
               
                   
                   
                   
                 synthetase 
               
               
                   
                   
                   
                 1G 
               
               
                 Acsbg1 
                 0.011451526 
                 ENSMUSG00000032281 
                 acyl-CoA 
                 2.97743206 
                 3.6239665 
                 0.64653444 
                 2.97743206 
               
               
                   
                   
                   
                 synthetase 
               
               
                   
                   
                   
                 bubblegum 
               
               
                   
                   
                   
                 family 
               
               
                   
                   
                   
                 member 1 
               
               
                 Srgn 
                 0.000519223 
                 ENSMUSG00000020077 
                 serglycin 
                 2.9888318 
                 4.8379955 
                 1.8491637 
                 2.9888318 
               
               
                 Cd300lf 
                 0.048743 
                 ENSMUSG00000047798 
                 CD300 
                 2.99401476 
                 0.83319426 
                 −2.1608205 
                 2.99401476 
               
               
                   
                   
                   
                 antigen like 
               
               
                   
                   
                   
                 family 
               
               
                   
                   
                   
                 member F 
               
               
                 Btg2 
                 0.013627362 
                 ENSMUSG00000020423 
                 B-cell 
                 3.04782124 
                 3.0390038 
                 −0.0088174 
                 3.04782124 
               
               
                   
                   
                   
                 translocation 
               
               
                   
                   
                   
                 gene 2, anti- 
               
               
                   
                   
                   
                 proliferative 
               
               
                 Lyz2 
                 0.000114821 
                 ENSMUSG00000069516 
                 lysozyme 2 
                 3.0592905 
                 8.7250185 
                 5.665728 
                 3.0592905 
               
               
                 Tmem176a 
                 0.001501859 
                 ENSMUSG00000023367 
                 transmembrane 
                 3.0797794 
                 4.3339963 
                 1.2542169 
                 3.0797794 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 176A 
               
               
                 Cd300ld 
                 0.006088423 
                 ENSMUSG00000034641 
                 CD300 
                 3.08196247 
                 3.1435344 
                 0.06157193 
                 3.08196247 
               
               
                   
                   
                   
                 molecule-like 
               
               
                   
                   
                   
                 family 
               
               
                   
                   
                   
                 member d 
               
               
                 Ikbke 
                 0.011466974 
                 ENSMUSG00000042349 
                 inhibitor of 
                 3.0988679 
                 3.468562 
                 0.3696941 
                 3.0988679 
               
               
                   
                   
                   
                 kappaB 
               
               
                   
                   
                   
                 kinase epsilon 
               
               
                 Sepw1 
                 0.021194948 
                 ENSMUSG00000041571 
                 selenoprotein 
                 3.10504645 
                 2.8617637 
                 −0.2432828 
                 3.10504645 
               
               
                   
                   
                   
                 W, muscle 1 
               
               
                 Hap1 
                 0.006396474 
                 ENSMUSG00000006930 
                 huntingtin- 
                 3.10895079 
                 3.1357572 
                 0.02680641 
                 3.10895079 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 protein 1 
               
               
                 Trim34a 
                 0.03032563 
                 ENSMUSG00000056144 
                 tripartite 
                 3.10989568 
                 2.8235443 
                 −0.2863514 
                 3.10989568 
               
               
                   
                   
                   
                 motif- 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 34A 
               
               
                 Ccl5 
                 0.025789276 
                 ENSMUSG00000035042 
                 chemokine 
                 3.1330606 
                 1.8897779 
                 −1.2432827 
                 3.1330606 
               
               
                   
                   
                   
                 (C-C motif) 
               
               
                   
                   
                   
                 ligand 5 
               
               
                 Phf11 
                 0.033611197 
                 ENSMUSG00000044703 
                 PHD finger 
                 3.16393976 
                 0.83319426 
                 −2.3307455 
                 3.16393976 
               
               
                   
                   
                   
                 protein 11 
               
               
                 Sp100 
                 6.08582E−05 
                 ENSMUSG00000026222 
                 nuclear 
                 3.1818978 
                 4.8955464 
                 1.7136486 
                 3.1818978 
               
               
                   
                   
                   
                 antigen 
               
               
                   
                   
                   
                 Sp100 
               
               
                 Gstt1 
                 3.95629E−06 
                 ENSMUSG00000001663 
                 glutathione S- 
                 3.1898814 
                 5.8534894 
                 2.663608 
                 3.1898814 
               
               
                   
                   
                   
                 transferase, 
               
               
                   
                   
                   
                 theta 1 
               
               
                 Irgm1 
                 1.61702E−05 
                 ENSMUSG00000046879 
                 immunity- 
                 3.1988442 
                 6.315182 
                 3.1163378 
                 3.1988442 
               
               
                   
                   
                   
                 related 
               
               
                   
                   
                   
                 GTPase family 
               
               
                   
                   
                   
                 M member 1 
               
               
                 Tnf 
                 1.1853E−05 
                 ENSMUSG00000024401 
                 tumor 
                 3.2128252 
                 6.417355 
                 3.2045298 
                 3.2128252 
               
               
                   
                   
                   
                 necrosis 
               
               
                   
                   
                   
                 factor 
               
               
                 Trib3 
                 0.008661835 
                 ENSMUSG00000032715 
                 tribbles 
                 3.24853782 
                 3.5902176 
                 0.34167978 
                 3.24853782 
               
               
                   
                   
                   
                 homolog 3 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Mcf2l 
                 0.029599534 
                 ENSMUSG00000031442 
                 mcf.2 
                 3.2570492 
                 1.0962287 
                 −2.1608205 
                 3.2570492 
               
               
                   
                   
                   
                 transforming 
               
               
                   
                   
                   
                 sequence-like 
               
               
                 Gm2619 
                 0.027174171 
                 ENSMUSG00000091199 
                 predicted 
                 3.27751335 
                 2.7541227 
                 −0.5233907 
                 3.27751335 
               
               
                   
                   
                   
                 gene 2619 
               
               
                 Ccl2 
                 2.73529E−05 
                 ENSMUSG00000035385 
                 chemokine 
                 3.2992415 
                 5.2446203 
                 1.9453788 
                 3.2992415 
               
               
                   
                   
                   
                 (C-C motif) 
               
               
                   
                   
                   
                 ligand 2 
               
               
                 Gm7592 
                 0.001554758 
                 ENSMUSG00000090186 
                 predicted 
                 3.31135076 
                 4.1704297 
                 0.85907894 
                 3.31135076 
               
               
                   
                   
                   
                 gene 7592 
               
               
                 Slamf9 
                 0.02308799 
                 ENSMUSG00000026548 
                 SLAM family 
                 3.31978506 
                 2.743927 
                 −0.5758581 
                 3.31978506 
               
               
                   
                   
                   
                 member 9 
               
               
                 P2ry6 
                 0.017429588 
                 ENSMUSG00000048779 
                 pyrimidinergic 
                 3.3331523 
                 2.5873692 
                 −0.7457831 
                 3.3331523 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 P2Y, G- 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 coupled, 6 
               
               
                 Slc9a4 
                 0.007401402 
                 ENSMUSG00000026065 
                 solute carrier 
                 3.3680806 
                 2.3592632 
                 −1.0088174 
                 3.3680806 
               
               
                   
                   
                   
                 family 9 
               
               
                   
                   
                   
                 (sodium/hydrogen 
               
               
                   
                   
                   
                 exchanger), 
               
               
                   
                   
                   
                 member 4 
               
               
                 Cth 
                 1.06479E−06 
                 ENSMUSG00000028179 
                 cystathionase 
                 3.376959 
                 4.760459 
                 1.3835 
                 3.376959 
               
               
                   
                   
                   
                 (cystathionine 
               
               
                   
                   
                   
                 gamma- 
               
               
                   
                   
                   
                 lyase) 
               
               
                 Tmem176b 
                 9.82651E−08 
                 ENSMUSG00000029810 
                 transmembrane 
                 3.4009837 
                 6.739123 
                 3.3381393 
                 3.4009837 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 176B 
               
               
                 Hao1 
                 0.010638081 
                 ENSMUSG00000027261 
                 hydroxyacid 
                 3.40718967 
                 3.0306404 
                 −0.3765493 
                 3.40718967 
               
               
                   
                   
                   
                 oxidase 1, 
               
               
                   
                   
                   
                 liver 
               
               
                 Socs3 
                 0.004106858 
                 ENSMUSG00000053113 
                 suppressor of 
                 3.41114926 
                 3.8617635 
                 0.45061424 
                 3.41114926 
               
               
                   
                   
                   
                 cytokine 
               
               
                   
                   
                   
                 signaling 3 
               
               
                 Gm5431 
                 0.03143841 
                 ENSMUSG00000058163 
                 predicted 
                 3.4162479 
                 1.6704649 
                 −1.745783 
                 3.4162479 
               
               
                   
                   
                   
                 gene 5431 
               
               
                 Slc7a11 
                 5.55815E−05 
                 ENSMUSG00000027737 
                 solute carrier 
                 3.4173804 
                 6.241453 
                 2.8240726 
                 3.4173804 
               
               
                   
                   
                   
                 family 7 
               
               
                   
                   
                   
                 (cationic 
               
               
                   
                   
                   
                 amino acid 
               
               
                   
                   
                   
                 transporter, 
               
               
                   
                   
                   
                 y+ system), 
               
               
                   
                   
                   
                 member 11 
               
               
                 Cd14 
                 1.38458E−06 
                 ENSMUSG00000051439 
                 CD14 antigen 
                 3.428314 
                 7.3783393 
                 3.9500253 
                 3.428314 
               
               
                 Cx3cr1 
                 0.010204745 
                 ENSMUSG00000052336 
                 chemokine 
                 3.45128475 
                 3.208002 
                 −0.2432828 
                 3.45128475 
               
               
                   
                   
                   
                 (C—X3—C) 
               
               
                   
                   
                   
                 receptor 1 
               
               
                 Gna15 
                 0.022787878 
                 ENSMUSG00000034792 
                 guanine 
                 3.4586832 
                 1.1279377 
                 −2.3307455 
                 3.4586832 
               
               
                   
                   
                   
                 nucleotide 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein, alpha 
               
               
                   
                   
                   
                 15 
               
               
                 Tifa 
                 0.03074038 
                 ENSMUSG00000046688 
                 TRAF- 
                 3.4756895 
                 1.6043756 
                 −1.8713139 
                 3.4756895 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 protein with 
               
               
                   
                   
                   
                 forkhead- 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 domain 
               
               
                 Slc2a6 
                 0.007765551 
                 ENSMUSG00000036067 
                 solute carrier 
                 3.4897101 
                 2.4808927 
                 −1.0088174 
                 3.4897101 
               
               
                   
                   
                   
                 family 2 
               
               
                   
                   
                   
                 (facilitated 
               
               
                   
                   
                   
                 glucose 
               
               
                   
                   
                   
                 transporter), 
               
               
                   
                   
                   
                 member 6 
               
               
                 Gm12185 
                 0.0202251 
                 ENSMUSG00000048852 
                 predicted 
                 3.50280586 
                 0.97941506 
                 −2.5233908 
                 3.50280586 
               
               
                   
                   
                   
                 gene 12185 
               
               
                 Ccl22 
                 0.01904264 
                 ENSMUSG00000031779 
                 chemokine 
                 3.5061447 
                 2.8758388 
                 −0.6303059 
                 3.5061447 
               
               
                   
                   
                   
                 (C-C motif) 
               
               
                   
                   
                   
                 ligand 22 
               
               
                 Gm7609 
                 0.002328847 
                 ENSMUSG00000079457 
                 predicted 
                 3.51338906 
                 3.937531 
                 0.42414194 
                 3.51338906 
               
               
                   
                   
                   
                 pseudogene 
               
               
                   
                   
                   
                 7609 
               
               
                 9930111J21Rik1 
                 0.015952412 
                 ENSMUSG00000069893 
                 RIKEN cDNA 
                 3.5533596 
                 2.8664703 
                 −0.6868893 
                 3.5533596 
               
               
                   
                   
                   
                 9930111J21 
               
               
                   
                   
                   
                 gene 1 
               
               
                 Oas1b 
                 0.006014395 
                 ENSMUSG00000029605 
                 2′-5′ 
                 3.55350672 
                 3.2227612 
                 −0.3307455 
                 3.55350672 
               
               
                   
                   
                   
                 oligoadenylate 
               
               
                   
                   
                   
                 synthetase 
               
               
                   
                   
                   
                 1B 
               
               
                 Oas2 
                 4.47082E−05 
                 ENSMUSG00000032690 
                 2′-5′ 
                 3.5568339 
                 6.3605146 
                 2.8036807 
                 3.5568339 
               
               
                   
                   
                   
                 oligoadenylate 
               
               
                   
                   
                   
                 synthetase 2 
               
               
                 C3ar1 
                 1.90141E−05 
                 ENSMUSG00000040552 
                 complement 
                 3.5586367 
                 5.8717475 
                 2.3131108 
                 3.5586367 
               
               
                   
                   
                   
                 component 
               
               
                   
                   
                   
                 3a receptor 1 
               
               
                 Xk 
                 0.016647717 
                 ENSMUSG00000015342 
                 Kell blood 
                 3.587198 
                 1.0638072 
                 −2.5233908 
                 3.587198 
               
               
                   
                   
                   
                 group 
               
               
                   
                   
                   
                 precursor 
               
               
                   
                   
                   
                 (McLeod 
               
               
                   
                   
                   
                 phenotype) 
               
               
                   
                   
                   
                 homolog 
               
               
                 Rcsd1 
                 0.00644401 
                 ENSMUSG00000040723 
                 RCSD domain 
                 3.6429406 
                 2.2190855 
                 −1.4238551 
                 3.6429406 
               
               
                   
                   
                   
                 containing 1 
               
               
                 Gm17446 
                 1.97358E−07 
                 ENSMUSG00000090648 
                 predicted 
                 3.6493672 
                 6.604024 
                 2.9546568 
                 3.6493672 
               
               
                   
                   
                   
                 gene, 17446 
               
               
                 Ms4a6c 
                 0.012355432 
                 ENSMUSG00000079419 
                 membrane- 
                 3.6525339 
                 2.022228 
                 −1.6303059 
                 3.6525339 
               
               
                   
                   
                   
                 spanning 4- 
               
               
                   
                   
                   
                 domains, 
               
               
                   
                   
                   
                 subfamily A, 
               
               
                   
                   
                   
                 member 6C 
               
               
                 Gbp3 
                 0.00609057 
                 ENSMUSG00000028268 
                 guanylate 
                 3.66391947 
                 3.2873702 
                 −0.3765493 
                 3.66391947 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 3 
               
               
                 Irf8 
                 0.005833246 
                 ENSMUSG00000041515 
                 interferon 
                 3.66485538 
                 3.2410004 
                 −0.423855 
                 3.66485538 
               
               
                   
                   
                   
                 regulatory 
               
               
                   
                   
                   
                 factor 8 
               
               
                 9930111J21Rik2 
                 0.002968723 
                 ENSMUSG00000069892 
                 RIKEN cDNA 
                 3.66551388 
                 3.3791625 
                 −0.2863514 
                 3.66551388 
               
               
                   
                   
                   
                 9930111J21 
               
               
                   
                   
                   
                 gene 2 
               
               
                 Nxf7 
                 0.026874818 
                 ENSMUSG00000031410 
                 nuclear RNA 
                 3.6684755 
                 1.6596581 
                 −2.0088174 
                 3.6684755 
               
               
                   
                   
                   
                 export factor 7 
               
               
                 4933421A08Rik 
                 0.04371277 
                 ENSMUSG00000086443 
                 RIKEN cDNA 
                 3.6900088 
                 −0.6407369 
                 −4.3307457 
                 3.6900088 
               
               
                   
                   
                   
                 4933421A08 
               
               
                   
                   
                   
                 gene 
               
               
                 Nfkbiz 
                 0.000338256 
                 ENSMUSG00000035356 
                 nuclear factor 
                 3.69558076 
                 4.4309244 
                 0.73534364 
                 3.69558076 
               
               
                   
                   
                   
                 of kappa light 
               
               
                   
                   
                   
                 polypeptide 
               
               
                   
                   
                   
                 gene 
               
               
                   
                   
                   
                 enhancer in 
               
               
                   
                   
                   
                 B-cells 
               
               
                   
                   
                   
                 inhibitor, zeta 
               
               
                 Cd33 
                 0.003050802 
                 ENSMUSG00000004609 
                 CD33 antigen 
                 3.7085288 
                 3.804048 
                 0.0955192 
                 3.7085288 
               
               
                 Tmem132a 
                 0.015127231 
                 ENSMUSG00000024736 
                 transmembrane 
                 3.764706 
                 2.9575224 
                 −0.8071836 
                 3.764706 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 132A 
               
               
                 Isg20 
                 0.012284132 
                 ENSMUSG00000039236 
                 interferon- 
                 3.8299389 
                 1.4991934 
                 −2.3307455 
                 3.8299389 
               
               
                   
                   
                   
                 stimulated 
               
               
                   
                   
                   
                 protein 
               
               
                 Oas3 
                 4.73984E−09 
                 ENSMUSG00000032661 
                 2′-5′ 
                 3.8306523 
                 7.3947244 
                 3.5640721 
                 3.8306523 
               
               
                   
                   
                   
                 oligoadenylate 
               
               
                   
                   
                   
                 synthetase 3 
               
               
                 Gm5483 
                 0.03113538 
                 ENSMUSG00000079597 
                 predicted 
                 3.84201193 
                 −0.4887338 
                 −4.3307457 
                 3.84201193 
               
               
                   
                   
                   
                 gene 5483 
               
               
                 Cd40 
                 0.008479672 
                 ENSMUSG00000017652 
                 CD40 antigen 
                 3.8493916 
                 3.2190857 
                 −0.6303059 
                 3.8493916 
               
               
                 Rab3il1 
                 0.002127681 
                 ENSMUSG00000024663 
                 RAB3A 
                 3.8658585 
                 2.535113 
                 −1.3307455 
                 3.8658585 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 protein 
               
               
                   
                   
                   
                 (rabin3)-like 1 
               
               
                 Atf3 
                 0.010065816 
                 ENSMUSG00000026628 
                 activating 
                 3.8931904 
                 3.1474073 
                 −0.7457831 
                 3.8931904 
               
               
                   
                   
                   
                 transcription 
               
               
                   
                   
                   
                 factor 3 
               
               
                 Neurl3 
                 0.002695141 
                 ENSMUSG00000047180 
                 neuralized 
                 3.93512115 
                 3.4117305 
                 −0.5233907 
                 3.93512115 
               
               
                   
                   
                   
                 homolog 3 
               
               
                   
                   
                   
                 homolog 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Gm216 
                 0.047322746 
                 ENSMUSG00000073650 
                 predicted 
                 3.9351214 
                 −1.3956243 
                 −5.3307457 
                 3.9351214 
               
               
                   
                   
                   
                 gene 216 
               
               
                 Aox3l1 
                 0.04825851 
                 ENSMUSG00000079554 
                 aldehyde 
                 3.9351214 
                 −1.3956243 
                 −5.3307457 
                 3.9351214 
               
               
                   
                   
                   
                 oxidase 3-like 1 
               
               
                 Slc39a4 
                 0.000711307 
                 ENSMUSG00000063354 
                 solute carrier 
                 3.94382097 
                 3.5672717 
                 −0.3765493 
                 3.94382097 
               
               
                   
                   
                   
                 family 39 
               
               
                   
                   
                   
                 (zinc 
               
               
                   
                   
                   
                 transporter), 
               
               
                   
                   
                   
                 member 4 
               
               
                 Trim30d 
                 0.012037092 
                 ENSMUSG00000057596 
                 tripartite 
                 3.94794524 
                 3.0095172 
                 −0.938428 
                 3.94794524 
               
               
                   
                   
                   
                 motif- 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 30D 
               
               
                 Trim30a 
                 1.61687E−07 
                 ENSMUSG00000030921 
                 tripartite 
                 3.971755 
                 6.3483686 
                 2.3766136 
                 3.971755 
               
               
                   
                   
                   
                 motif- 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 30A 
               
               
                 Cd244 
                 0.047936272 
                 ENSMUSG00000004709 
                 CD244 
                 3.9940152 
                 −1.4887338 
                 −5.482749 
                 3.9940152 
               
               
                   
                   
                   
                 natural killer 
               
               
                   
                   
                   
                 cell receptor 
               
               
                   
                   
                   
                 2B4 
               
               
                 Adam33 
                 0.048501696 
                 ENSMUSG00000027318 
                 a disintegrin 
                 3.9940152 
                 −1.4887338 
                 −5.482749 
                 3.9940152 
               
               
                   
                   
                   
                 and 
               
               
                   
                   
                   
                 metallopeptidase 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 33 
               
               
                 Art3 
                 0.049302656 
                 ENSMUSG00000034842 
                 ADP- 
                 3.9940152 
                 −1.4887338 
                 −5.482749 
                 3.9940152 
               
               
                   
                   
                   
                 ribosyltransferase 3 
               
               
                 Evl 
                 0.01699222 
                 ENSMUSG00000021262 
                 Ena- 
                 4.0225842 
                 0.6918385 
                 −3.3307457 
                 4.0225842 
               
               
                   
                   
                   
                 vasodilator 
               
               
                   
                   
                   
                 stimulated 
               
               
                   
                   
                   
                 phosphoprotein 
               
               
                 BC049352 
                 0.019156335 
                 ENSMUSG00000091996 
                 cDNA 
                 4.0225842 
                 −0.3081615 
                 −4.3307457 
                 4.0225842 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 BC049352 
               
               
                 Ms4a7 
                 0.04587867 
                 ENSMUSG00000024672 
                 membrane- 
                 4.0225842 
                 −1.3081615 
                 −5.3307457 
                 4.0225842 
               
               
                   
                   
                   
                 spanning 4- 
               
               
                   
                   
                   
                 domains, 
               
               
                   
                   
                   
                 subfamily A, 
               
               
                   
                   
                   
                 member 7 
               
               
                 Cnrip1 
                 0.04739232 
                 ENSMUSG00000044629 
                 cannabinoid 
                 4.0225842 
                 −1.3081615 
                 −5.3307457 
                 4.0225842 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 protein 1 
               
               
                 Gbp2 
                 0.04953059 
                 ENSMUSG00000028270 
                 guanylate 
                 4.0225842 
                 −1.3081615 
                 −5.3307457 
                 4.0225842 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 2 
               
               
                 Rbpms 
                 0.017674573 
                 ENSMUSG00000031586 
                 RNA binding 
                 4.0644043 
                 0.7336586 
                 −3.3307457 
                 4.0644043 
               
               
                   
                   
                   
                 protein gene 
               
               
                   
                   
                   
                 with multiple 
               
               
                   
                   
                   
                 splicing 
               
               
                 Leprel1 
                 0.015996631 
                 ENSMUSG00000038168 
                 leprecan-like 1 
                 4.06440437 
                 −0.2663413 
                 −4.3307457 
                 4.06440437 
               
               
                 Adam3 
                 0.009531343 
                 ENSMUSG00000031553 
                 a disintegrin 
                 4.0726246 
                 1.0638072 
                 −3.0088174 
                 4.0726246 
               
               
                   
                   
                   
                 and 
               
               
                   
                   
                   
                 metallopeptidase 
               
               
                   
                   
                   
                 domain 3 
               
               
                   
                   
                   
                 (cyritestin) 
               
               
                 Trim34b 
                 0.007744697 
                 ENSMUSG00000090215 
                 tripartite 
                 4.0807986 
                 2.0719812 
                 −2.0088174 
                 4.0807986 
               
               
                   
                   
                   
                 motif- 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 34B 
               
               
                 Pilrb1 
                 0.0480939 
                 ENSMUSG00000066684 
                 paired 
                 4.0871247 
                 −1.3956243 
                 −5.482749 
                 4.0871247 
               
               
                   
                   
                   
                 immunoglobin- 
               
               
                   
                   
                   
                 like type 2 
               
               
                   
                   
                   
                 receptor beta 1 
               
               
                 Prickle1 
                 0.048321296 
                 ENSMUSG00000036158 
                 prickle 
                 4.0871247 
                 −1.3956243 
                 −5.482749 
                 4.0871247 
               
               
                   
                   
                   
                 homolog 1 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Ccrl2 
                 0.048543822 
                 ENSMUSG00000043953 
                 chemokine 
                 4.0871247 
                 −1.3956243 
                 −5.482749 
                 4.0871247 
               
               
                   
                   
                   
                 (C-C motif) 
               
               
                   
                   
                   
                 receptor-like 2 
               
               
                 1700003M07Rik 
                 0.0489742 
                 ENSMUSG00000085389 
                 RIKEN cDNA 
                 4.0871247 
                 −1.3956243 
                 −5.482749 
                 4.0871247 
               
               
                   
                   
                   
                 1700003M07 
               
               
                   
                   
                   
                 gene 
               
               
                 Nphs2 
                 0.04948828 
                 ENSMUSG00000026602 
                 nephrosis 2 
                 4.0871247 
                 −1.3956243 
                 −5.482749 
                 4.0871247 
               
               
                   
                   
                   
                 homolog, 
               
               
                   
                   
                   
                 podocin 
               
               
                   
                   
                   
                 (human) 
               
               
                 Il10ra 
                 0.003073455 
                 ENSMUSG00000032089 
                 interleukin 10 
                 4.10113089 
                 4.1279373 
                 0.02680641 
                 4.10113089 
               
               
                   
                   
                   
                 receptor, 
               
               
                   
                   
                   
                 alpha 
               
               
                 Gadd45a 
                 0.043100644 
                 ENSMUSG00000036390 
                 growth arrest 
                 4.1050463 
                 −1.2256994 
                 −5.3307457 
                 4.1050463 
               
               
                   
                   
                   
                 and DNA- 
               
               
                   
                   
                   
                 damage- 
               
               
                   
                   
                   
                 inducible 45 
               
               
                   
                   
                   
                 alpha 
               
               
                 6530402F18Rik 
                 0.044838425 
                 ENSMUSG00000079499 
                 RIKEN cDNA 
                 4.1050463 
                 −1.2256994 
                 −5.3307457 
                 4.1050463 
               
               
                   
                   
                   
                 6530402F18 
               
               
                   
                   
                   
                 gene 
               
               
                 Irgm2 
                 1.04727E−05 
                 ENSMUSG00000069874 
                 immunity- 
                 4.1400689 
                 4.509763 
                 0.3696941 
                 4.1400689 
               
               
                   
                   
                   
                 related 
               
               
                   
                   
                   
                 GTPase family 
               
               
                   
                   
                   
                 M member 2 
               
               
                 Gpr84 
                 2.75089E−05 
                 ENSMUSG00000063234 
                 G protein- 
                 4.14575538 
                 3.859404 
                 −0.2863514 
                 4.14575538 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 receptor 84 
               
               
                 Atp8b4 
                 2.32191E−07 
                 ENSMUSG00000060131 
                 ATPase, class 
                 4.1493087 
                 6.0280166 
                 1.8787079 
                 4.1493087 
               
               
                   
                   
                   
                 I, type 8B, 
               
               
                   
                   
                   
                 member 4 
               
               
                 Pi16 
                 0.04246121 
                 ENSMUSG00000024011 
                 peptidase 
                 4.1830488 
                 −1.1476969 
                 −5.3307457 
                 4.1830488 
               
               
                   
                   
                   
                 inhibitor 16 
               
               
                 9430070O13Rik 
                 0.042740114 
                 ENSMUSG00000026601 
                 RIKEN cDNA 
                 4.1830488 
                 −1.1476969 
                 −5.3307457 
                 4.1830488 
               
               
                   
                   
                   
                 9430070O13 
               
               
                   
                   
                   
                 gene 
               
               
                 Xaf1 
                 0.004594872 
                 ENSMUSG00000040483 
                 XIAP 
                 4.1863461 
                 3.3791625 
                 −0.8071836 
                 4.1863461 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 factor 1 
               
               
                 Gbp9 
                 0.009429601 
                 ENSMUSG00000029298 
                 guanylate- 
                 4.1956487 
                 1.4498657 
                 −2.745783 
                 4.1956487 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 9 
               
               
                 Aldh1l2 
                 9.31273E−08 
                 ENSMUSG00000020256 
                 aldehyde 
                 4.268145 
                 6.0248623 
                 1.7567173 
                 4.268145 
               
               
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                 1 family, 
               
               
                   
                   
                   
                 member L2 
               
               
                 Ceacam19 
                 0.01110833 
                 ENSMUSG00000049848 
                 carcinoembryonic 
                 4.2690218 
                 1.5232388 
                 −2.745783 
                 4.2690218 
               
               
                   
                   
                   
                 antigen- 
               
               
                   
                   
                   
                 related cell 
               
               
                   
                   
                   
                 adhesion 
               
               
                   
                   
                   
                 molecule 19 
               
               
                 Siglec1 
                 0.000273761 
                 ENSMUSG00000027322 
                 sialic acid 
                 4.26931259 
                 4.296119 
                 0.02680641 
                 4.26931259 
               
               
                   
                   
                   
                 binding Ig-like 
               
               
                   
                   
                   
                 lectin 1, 
               
               
                   
                   
                   
                 sialoadhesin 
               
               
                 Nhsl1 
                 0.007009061 
                 ENSMUSG00000039835 
                 NHS-like 1 
                 4.3043549 
                 1.5585719 
                 −2.745783 
                 4.3043549 
               
               
                 Mx1 
                 0.014547019 
                 ENSMUSG00000000386 
                 myxovirus 
                 4.32743881 
                 −0.0033069 
                 −4.3307457 
                 4.32743881 
               
               
                   
                   
                   
                 (influenza 
               
               
                   
                   
                   
                 virus) 
               
               
                   
                   
                   
                 resistance 1 
               
               
                 Il1b 
                 0.038834058 
                 ENSMUSG00000027398 
                 interleukin 1 
                 4.3350521 
                 −1.1476969 
                 −5.482749 
                 4.3350521 
               
               
                   
                   
                   
                 beta 
               
               
                 Emr1 
                 1.82451E−06 
                 ENSMUSG00000004730 
                 EGF-like 
                 4.360369 
                 5.65898 
                 1.298611 
                 4.360369 
               
               
                   
                   
                   
                 module 
               
               
                   
                   
                   
                 containing, 
               
               
                   
                   
                   
                 mucin-like, 
               
               
                   
                   
                   
                 hormone 
               
               
                   
                   
                   
                 receptor-like 
               
               
                   
                   
                   
                 sequence 1 
               
               
                 Parp14 
                 1.93595E−08 
                 ENSMUSG00000034422 
                 poly (ADP- 
                 4.3674735 
                 6.3035145 
                 1.936041 
                 4.3674735 
               
               
                   
                   
                   
                 ribose) 
               
               
                   
                   
                   
                 polymerase 
               
               
                   
                   
                   
                 family, 
               
               
                   
                   
                   
                 member 14 
               
               
                 D14Ertd668e 
                 1.30197E−05 
                 ENSMUSG00000068245 
                 DNA 
                 4.36899129 
                 4.4976773 
                 0.12868601 
                 4.36899129 
               
               
                   
                   
                   
                 segment, Chr 
               
               
                   
                   
                   
                 14, ERATO 
               
               
                   
                   
                   
                 Doi 668, 
               
               
                   
                   
                   
                 expressed 
               
               
                 Igtp 
                 0.001563031 
                 ENSMUSG00000078853 
                 interferon 
                 4.3773436 
                 3.57016 
                 −0.8071836 
                 4.3773436 
               
               
                   
                   
                   
                 gamma 
               
               
                   
                   
                   
                 induced 
               
               
                   
                   
                   
                 GTPase 
               
               
                 Gstt4 
                 0.011173716 
                 ENSMUSG00000009093 
                 glutathione S- 
                 4.3780647 
                 2.0473192 
                 −2.3307455 
                 4.3780647 
               
               
                   
                   
                   
                 transferase, 
               
               
                   
                   
                   
                 theta 4 
               
               
                 Stap1 
                 2.50132E−07 
                 ENSMUSG00000029254 
                 signal 
                 4.3900233 
                 6.239187 
                 1.8491637 
                 4.3900233 
               
               
                   
                   
                   
                 transducing 
               
               
                   
                   
                   
                 adaptor 
               
               
                   
                   
                   
                 family 
               
               
                   
                   
                   
                 member 1 
               
               
                 Tpbg 
                 0.03382182 
                 ENSMUSG00000035274 
                 trophoblast 
                 4.4090527 
                 −1.0736963 
                 −5.482749 
                 4.4090527 
               
               
                   
                   
                   
                 glycoprotein 
               
               
                 Wdr66 
                 0.013581607 
                 ENSMUSG00000029442 
                 WD repeat 
                 4.45868316 
                 0.71290016 
                 −3.745783 
                 4.45868316 
               
               
                   
                   
                   
                 domain 66 
               
               
                 Hunk 
                 0.01660839 
                 ENSMUSG00000053414 
                 hormonally 
                 4.48971018 
                 0.15896448 
                 −4.3307457 
                 4.48971018 
               
               
                   
                   
                   
                 upregulated 
               
               
                   
                   
                   
                 Neu- 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 kinase 
               
               
                 Saa3 
                 0.025470588 
                 ENSMUSG00000040026 
                 serum 
                 4.5200839 
                 −0.8106618 
                 −5.3307457 
                 4.5200839 
               
               
                   
                   
                   
                 amyloid A 3 
               
               
                 Ifih1 
                 7.52283E−06 
                 ENSMUSG00000026896 
                 interferon 
                 4.52452936 
                 4.9486713 
                 0.42414194 
                 4.52452936 
               
               
                   
                   
                   
                 induced with 
               
               
                   
                   
                   
                 helicase C 
               
               
                   
                   
                   
                 domain 1 
               
               
                 Tlr13 
                 0.004782067 
                 ENSMUSG00000033777 
                 toll-like 
                 4.5446259 
                 3.3013432 
                 −1.2432827 
                 4.5446259 
               
               
                   
                   
                   
                 receptor 13 
               
               
                 Trim30eps1 
                 0.029862829 
                 ENSMUSG00000073929 
                 tripartite 
                 4.6106866 
                 −0.8720624 
                 −5.482749 
                 4.6106866 
               
               
                   
                   
                   
                 motif- 
               
               
                   
                   
                   
                 containing 
               
               
                   
                   
                   
                 30E, 
               
               
                   
                   
                   
                 pseudogene 1 
               
               
                 Six4 
                 0.006483047 
                 ENSMUSG00000034460 
                 sine oculis- 
                 4.63556084 
                 0.88977784 
                 −3.745783 
                 4.63556084 
               
               
                   
                   
                   
                 related 
               
               
                   
                   
                   
                 homeobox 4 
               
               
                   
                   
                   
                 homolog 
               
               
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Cybb 
                 1.95579E−07 
                 ENSMUSG00000015340 
                 cytochrome 
                 4.7431125 
                 5.752217 
                 1.0091045 
                 4.7431125 
               
               
                   
                   
                   
                 b-245, beta 
               
               
                   
                   
                   
                 polypeptide 
               
               
                 BC013712 
                 0.000281571 
                 ENSMUSG00000037731 
                 cDNA 
                 4.7587783 
                 3.8874643 
                 −0.871314 
                 4.7587783 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 BC013712 
               
               
                 Galnt3 
                 0.00355866 
                 ENSMUSG00000026994 
                 No 
                 4.7595498 
                 2.0137668 
                 −2.745783 
                 4.7595498 
               
               
                   
                   
                   
                 description 
               
               
                 Tnnt2 
                 0.02091825 
                 ENSMUSG00000026414 
                 troponin T2, 
                 4.7875644 
                 −0.6951846 
                 −5.482749 
                 4.7875644 
               
               
                   
                   
                   
                 cardiac 
               
               
                 Fabp4 
                 0.021602802 
                 ENSMUSG00000062515 
                 fatty acid 
                 4.7875644 
                 −0.6951846 
                 −5.482749 
                 4.7875644 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 4, 
               
               
                   
                   
                   
                 adipocyte 
               
               
                 Slpi 
                 0.01807874 
                 ENSMUSG00000017002 
                 secretory 
                 4.7931023 
                 0.4623566 
                 −4.3307457 
                 4.7931023 
               
               
                   
                   
                   
                 leukocyte 
               
               
                   
                   
                   
                 peptidase 
               
               
                   
                   
                   
                 inhibitor 
               
               
                 Ifi44 
                 1.53211E−14 
                 ENSMUSG00000028037 
                 interferon- 
                 4.8898906 
                 8.224481 
                 3.3345904 
                 4.8898906 
               
               
                   
                   
                   
                 induced 
               
               
                   
                   
                   
                 protein 44 
               
               
                 AI504432 
                 0.019602522 
                 ENSMUSG00000056145 
                 expressed 
                 4.8944795 
                 −0.5882695 
                 −5.482749 
                 4.8944795 
               
               
                   
                   
                   
                 sequence 
               
               
                   
                   
                   
                 AI504432 
               
               
                 Ddx60 
                 0.000261457 
                 ENSMUSG00000037921 
                 DEAD (Asp- 
                 4.923806 
                 3.178023 
                 −1.745783 
                 4.923806 
               
               
                   
                   
                   
                 Glu-Ala-Asp) 
               
               
                   
                   
                   
                 box 
               
               
                   
                   
                   
                 polypeptide 
               
               
                   
                   
                   
                 60 
               
               
                 Slc9a9 
                 0.020172823 
                 ENSMUSG00000031129 
                 solute carrier 
                 4.9451056 
                 −0.5376434 
                 −5.482749 
                 4.9451056 
               
               
                   
                   
                   
                 family 9 
               
               
                   
                   
                   
                 (sodium/hydrogen 
               
               
                   
                   
                   
                 exchanger), 
               
               
                   
                   
                   
                 member 9 
               
               
                 Ccl7 
                 0.000610965 
                 ENSMUSG00000035373 
                 chemokine 
                 4.9591955 
                 3.3288896 
                 −1.6303059 
                 4.9591955 
               
               
                   
                   
                   
                 (C-C motif) 
               
               
                   
                   
                   
                 ligand 7 
               
               
                 Ddx58 
                 3.12944E−11 
                 ENSMUSG00000040296 
                 DEAD (Asp- 
                 4.9671744 
                 7.1678104 
                 2.200636 
                 4.9671744 
               
               
                   
                   
                   
                 Glu-Ala-Asp) 
               
               
                   
                   
                   
                 box 
               
               
                   
                   
                   
                 polypeptide 
               
               
                   
                   
                   
                 58 
               
               
                 I830012O16Rik 
                 0.004567375 
                 ENSMUSG00000062488 
                 RIKEN cDNA 
                 4.9940149 
                 1.2482319 
                 −3.745783 
                 4.9940149 
               
               
                   
                   
                   
                 I830012O16 
               
               
                   
                   
                   
                 gene 
               
               
                 Irf7 
                 8.24433E−07 
                 ENSMUSG00000025498 
                 interferon 
                 5.01074876 
                 5.4348907 
                 0.42414194 
                 5.01074876 
               
               
                   
                   
                   
                 regulatory 
               
               
                   
                   
                   
                 factor 7 
               
               
                 Htra4 
                 0.017311335 
                 ENSMUSG00000037406 
                 HtrA serine 
                 5.04132096 
                 −0.441428 
                 −5.482749 
                 5.04132096 
               
               
                   
                   
                   
                 peptidase 4 
               
               
                 Siglece 
                 0.00169967 
                 ENSMUSG00000030474 
                 sialic acid 
                 5.0807986 
                 2.0719812 
                 −3.0088174 
                 5.0807986 
               
               
                   
                   
                   
                 binding Ig-like 
               
               
                   
                   
                   
                 lectin E 
               
               
                 Aqp9 
                 0.000577649 
                 ENSMUSG00000032204 
                 aquaporin 9 
                 5.088251 
                 3.342468 
                 −1.745783 
                 5.088251 
               
               
                 Adh7 
                 0.002669529 
                 ENSMUSG00000055301 
                 alcohol 
                 5.1050461 
                 1.3592631 
                 −3.745783 
                 5.1050461 
               
               
                   
                   
                   
                 dehydrogenase 
               
               
                   
                   
                   
                 7 (class IV), 
               
               
                   
                   
                   
                 mu or sigma 
               
               
                   
                   
                   
                 polypeptide 
               
               
                 Slc30a2 
                 0.014447143 
                 ENSMUSG00000028836 
                 solute carrier 
                 5.10504635 
                 −0.2256994 
                 −5.3307457 
                 5.10504635 
               
               
                   
                   
                   
                 family 30 
               
               
                   
                   
                   
                 (zinc 
               
               
                   
                   
                   
                 transporter), 
               
               
                   
                   
                   
                 member 2 
               
               
                 Cd86 
                 0.00104289 
                 ENSMUSG00000022901 
                 CD86 antigen 
                 5.1249457 
                 2.7942002 
                 −2.3307455 
                 5.1249457 
               
               
                 Hsh2d 
                 0.009497254 
                 ENSMUSG00000062007 
                 hematopoietic 
                 5.16393996 
                 0.83319426 
                 −4.3307457 
                 5.16393996 
               
               
                   
                   
                   
                 SH2 domain 
               
               
                   
                   
                   
                 containing 
               
               
                 Ccnd2 
                 0.000857036 
                 ENSMUSG00000000184 
                 cyclin D2 
                 5.1779776 
                 3.7541225 
                 −1.4238551 
                 5.1779776 
               
               
                 Asb2 
                 0.008776278 
                 ENSMUSG00000021200 
                 ankyrin 
                 5.1830489 
                 0.8523032 
                 −4.3307457 
                 5.1830489 
               
               
                   
                   
                   
                 repeat and 
               
               
                   
                   
                   
                 SOCS box- 
               
               
                   
                   
                   
                 containing 2 
               
               
                 Gm1966 
                 0.009493642 
                 ENSMUSG00000073902 
                 predicted 
                 5.20190794 
                 0.87116224 
                 −4.3307457 
                 5.20190794 
               
               
                   
                   
                   
                 gene 1966 
               
               
                 Col14a1 
                 0.012412123 
                 ENSMUSG00000022371 
                 collagen, type 
                 5.21640767 
                 −0.2663413 
                 −5.482749 
                 5.21640767 
               
               
                   
                   
                   
                 XIV, alpha 1 
               
               
                 Clec4a1 
                 0.003088675 
                 ENSMUSG00000049037 
                 C-type lectin 
                 5.2205235 
                 2.4747405 
                 −2.745783 
                 5.2205235 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 family 4, 
               
               
                   
                   
                   
                 member a1 
               
               
                 Gm11711 
                 0.000704584 
                 ENSMUSG00000089722 
                 predicted 
                 5.2926734 
                 2.7692826 
                 −2.5233908 
                 5.2926734 
               
               
                   
                   
                   
                 gene 11711 
               
               
                 Gbp5 
                 0.012722499 
                 ENSMUSG00000040264 
                 guanylate 
                 5.29657803 
                 −0.186171 
                 −5.482749 
                 5.29657803 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 5 
               
               
                 Gm11710 
                 0.000707052 
                 ENSMUSG00000069609 
                 predicted 
                 5.2976914 
                 2.7743006 
                 −2.5233908 
                 5.2976914 
               
               
                   
                   
                   
                 gene 11710 
               
               
                 Cd300lh 
                 0.000719966 
                 ENSMUSG00000069607 
                 CD300 
                 5.3026922 
                 2.7793014 
                 −2.5233908 
                 5.3026922 
               
               
                   
                   
                   
                 antigen like 
               
               
                   
                   
                   
                 family 
               
               
                   
                   
                   
                 member H 
               
               
                 Kcna3 
                 0.007314483 
                 ENSMUSG00000047959 
                 potassium 
                 5.36138606 
                 0.03064036 
                 −5.3307457 
                 5.36138606 
               
               
                   
                   
                   
                 voltage-gated 
               
               
                   
                   
                   
                 channel, 
               
               
                   
                   
                   
                 shaker- 
               
               
                   
                   
                   
                 related 
               
               
                   
                   
                   
                 subfamily, 
               
               
                   
                   
                   
                 member 3 
               
               
                 Niacr1 
                 0.000542988 
                 ENSMUSG00000045502 
                 niacin 
                 5.3709405 
                 2.8475497 
                 −2.5233908 
                 5.3709405 
               
               
                   
                   
                   
                 receptor 1 
               
               
                 Dhx58 
                 1.07756E−08 
                 ENSMUSG00000017830 
                 DEXH (Asp- 
                 5.41137727 
                 5.034828 
                 −0.3765493 
                 5.41137727 
               
               
                   
                   
                   
                 Glu-X-His) 
               
               
                   
                   
                   
                 box 
               
               
                   
                   
                   
                 polypeptide 
               
               
                   
                   
                   
                 58 
               
               
                 Cmpk2 
                 1.21268E−06 
                 ENSMUSG00000020638 
                 cytidine 
                 5.42365352 
                 4.950889 
                 −0.4727645 
                 5.42365352 
               
               
                   
                   
                   
                 monophosphate 
               
               
                   
                   
                   
                 (UMP- 
               
               
                   
                   
                   
                 CMP) kinase 
               
               
                   
                   
                   
                 2, 
               
               
                   
                   
                   
                 mitochondrial 
               
               
                 Irak3 
                 0.000561619 
                 ENSMUSG00000020227 
                 interleukin-1 
                 5.4246825 
                 3.9012918 
                 −1.5233907 
                 5.4246825 
               
               
                   
                   
                   
                 receptor- 
               
               
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                 kinase 3 
               
               
                 Lysmd2 
                 0.007453424 
                 ENSMUSG00000032184 
                 LysM, 
                 5.42697442 
                 0.09622872 
                 −5.3307457 
                 5.42697442 
               
               
                   
                   
                   
                 putative 
               
               
                   
                   
                   
                 peptidoglycan- 
               
               
                   
                   
                   
                 binding, 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 2 
               
               
                 Cxcl10 
                 0.000436733 
                 ENSMUSG00000034855 
                 chemokine 
                 5.4269746 
                 2.9035838 
                 −2.5233908 
                 5.4269746 
               
               
                   
                   
                   
                 (C—X—C motif) 
               
               
                   
                   
                   
                 ligand 10 
               
               
                 C5ar1 
                 8.91278E−05 
                 ENSMUSG00000049130 
                 complement 
                 5.4794421 
                 4.055587 
                 −1.4238551 
                 5.4794421 
               
               
                   
                   
                   
                 component 
               
               
                   
                   
                   
                 5a receptor 1 
               
               
                 Ifit2 
                 0.000635787 
                 ENSMUSG00000045932 
                 interferon- 
                 5.4802343 
                 3.8499284 
                 −1.6303059 
                 5.4802343 
               
               
                   
                   
                   
                 induced 
               
               
                   
                   
                   
                 protein with 
               
               
                   
                   
                   
                 tetratricopeptide 
               
               
                   
                   
                   
                 repeats 2 
               
               
                 Gm15655 
                 0.009071947 
                 ENSMUSG00000086717 
                 predicted 
                 5.51338936 
                 0.03064036 
                 −5.482749 
                 5.51338936 
               
               
                   
                   
                   
                 gene 15655 
               
               
                 Apol9b 
                 0.000853888 
                 ENSMUSG00000057346 
                 apolipoprotein 
                 5.5350342 
                 2.2042885 
                 −3.3307457 
                 5.5350342 
               
               
                   
                   
                   
                 L 9b 
               
               
                 4930438A08Rik 
                 0.008135167 
                 ENSMUSG00000069873 
                 RIKEN cDNA 
                 5.54655632 
                 0.06380732 
                 −5.482749 
                 5.54655632 
               
               
                   
                   
                   
                 4930438A08 
               
               
                   
                   
                   
                 gene 
               
               
                 Slamf7 
                 0.008154977 
                 ENSMUSG00000038179 
                 SLAM family 
                 5.54655632 
                 0.06380732 
                 −5.482749 
                 5.54655632 
               
               
                   
                   
                   
                 member 7 
               
               
                 Trem3 
                 0.007723238 
                 ENSMUSG00000041754 
                 triggering 
                 5.57897772 
                 0.09622872 
                 −5.482749 
                 5.57897772 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 expressed on 
               
               
                   
                   
                   
                 myeloid cells 3 
               
               
                 Il10 
                 0.006503063 
                 ENSMUSG00000016529 
                 interleukin 10 
                 5.61068666 
                 0.12793766 
                 −5.482749 
                 5.61068666 
               
               
                 Itga9 
                 0.006992263 
                 ENSMUSG00000039115 
                 integrin alpha 9 
                 5.61068666 
                 0.12793766 
                 −5.482749 
                 5.61068666 
               
               
                 Rnase4 
                 0.000401531 
                 ENSMUSG00000021876 
                 ribonuclease, 
                 5.7743251 
                 2.4435794 
                 −3.3307457 
                 5.7743251 
               
               
                   
                   
                   
                 RNase A 
               
               
                   
                   
                   
                 family 4 
               
               
                 Rtp4 
                 2.66731E−08 
                 ENSMUSG00000033355 
                 receptor 
                 5.78130823 
                 5.6204877 
                 −0.1608205 
                 5.78130823 
               
               
                   
                   
                   
                 transporter 
               
               
                   
                   
                   
                 protein 4 
               
               
                 Itgal 
                 8.11603E−08 
                 ENSMUSG00000030830 
                 integrin alpha L 
                 5.80660638 
                 5.520255 
                 −0.2863514 
                 5.80660638 
               
               
                 Isg15 
                 4.77137E−05 
                 ENSMUSG00000035692 
                 ISG15 
                 5.8244175 
                 4.9531035 
                 −0.871314 
                 5.8244175 
               
               
                   
                   
                   
                 ubiquitin-like 
               
               
                   
                   
                   
                 modifier 
               
               
                 Cd300e 
                 0.000227213 
                 ENSMUSG00000048498 
                 CD300e 
                 5.9200143 
                 2.1742313 
                 −3.745783 
                 5.9200143 
               
               
                   
                   
                   
                 antigen 
               
               
                 Zbp1 
                 0.000939954 
                 ENSMUSG00000027514 
                 Z-DNA 
                 5.9463487 
                 1.615603 
                 −4.3307457 
                 5.9463487 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 1 
               
               
                 Ifit3 
                 0.00091502 
                 ENSMUSG00000074896 
                 interferon- 
                 5.9574891 
                 1.6267434 
                 −4.3307457 
                 5.9574891 
               
               
                   
                   
                   
                 induced 
               
               
                   
                   
                   
                 protein with 
               
               
                   
                   
                   
                 tetratricopeptide 
               
               
                   
                   
                   
                 repeats 3 
               
               
                 Gpr65 
                 8.52311E−06 
                 ENSMUSG00000021886 
                 G-protein 
                 5.9849697 
                 3.6542242 
                 −2.3307455 
                 5.9849697 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 receptor 65 
               
               
                 Gm11428 
                 0.001755864 
                 ENSMUSG00000069792 
                 predicted 
                 6.04132093 
                 0.55857193 
                 −5.482749 
                 6.04132093 
               
               
                   
                   
                   
                 gene 11428 
               
               
                 Ccl4 
                 8.01905E−11 
                 ENSMUSG00000018930 
                 chemokine 
                 6.04364554 
                 6.54579 
                 0.50214446 
                 6.04364554 
               
               
                   
                   
                   
                 (C-C motif) 
               
               
                   
                   
                   
                 ligand 4 
               
               
                 Gm14085 
                 0.000702213 
                 ENSMUSG00000079071 
                 predicted 
                 6.0644043 
                 0.7336586 
                 −5.3307457 
                 6.0644043 
               
               
                   
                   
                   
                 gene 14085 
               
               
                 Lcn2 
                 0.000630766 
                 ENSMUSG00000026822 
                 lipocalin 2 
                 6.2164076 
                 0.7336586 
                 −5.482749 
                 6.2164076 
               
               
                 Apol9a 
                 0.000453771 
                 ENSMUSG00000068246 
                 apolipoprotein 
                 6.2660382 
                 2.9352925 
                 −3.3307457 
                 6.2660382 
               
               
                   
                   
                   
                 L 9a 
               
               
                 Tnfrsf13b 
                 0.000442462 
                 ENSMUSG00000010142 
                 tumor 
                 6.3317263 
                 3.0009806 
                 −3.3307457 
                 6.3317263 
               
               
                   
                   
                   
                 necrosis 
               
               
                   
                   
                   
                 factor 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 superfamily, 
               
               
                   
                   
                   
                 member 13b 
               
               
                 Maf 
                 3.9675E−06 
                 ENSMUSG00000055435 
                 avian 
                 6.3557831 
                 3.6100001 
                 −2.745783 
                 6.3557831 
               
               
                   
                   
                   
                 musculoaponeurotic 
               
               
                   
                   
                   
                 fibrosarcoma 
               
               
                   
                   
                   
                 (v-maf) AS42 
               
               
                   
                   
                   
                 oncogene 
               
               
                   
                   
                   
                 homolog 
               
               
                 Gm4070 
                 9.03925E−07 
                 ENSMUSG00000078606 
                 predicted 
                 6.3693103 
                 5.2864923 
                 −1.082818 
                 6.3693103 
               
               
                   
                   
                   
                 gene 4070 
               
               
                 Gvin1 
                 7.25705E−07 
                 ENSMUSG00000045868 
                 GTPase, very 
                 6.3885 
                 5.305682 
                 −1.082818 
                 6.3885 
               
               
                   
                   
                   
                 large 
               
               
                   
                   
                   
                 interferon 
               
               
                   
                   
                   
                 inducible 1 
               
               
                 Usp18 
                 4.19049E−11 
                 ENSMUSG00000030107 
                 ubiquitin 
                 6.46699962 
                 6.690843 
                 0.22384338 
                 6.46699962 
               
               
                   
                   
                   
                 specific 
               
               
                   
                   
                   
                 peptidase 18 
               
               
                 Slc28a2 
                 0.000986595 
                 ENSMUSG00000027219 
                 solute carrier 
                 6.564478 
                 1.2337323 
                 −5.3307457 
                 6.564478 
               
               
                   
                   
                   
                 family 28 
               
               
                   
                   
                   
                 (sodium- 
               
               
                   
                   
                   
                 coupled 
               
               
                   
                   
                   
                 nucleoside 
               
               
                   
                   
                   
                 transporter), 
               
               
                   
                   
                   
                 member 2 
               
               
                 Slc15a3 
                 1.36526E−11 
                 ENSMUSG00000024737 
                 solute carrier 
                 6.58377798 
                 6.159923 
                 −0.423855 
                 6.58377798 
               
               
                   
                   
                   
                 family 15, 
               
               
                   
                   
                   
                 member 3 
               
               
                 Gm11547 
                 0.000421104 
                 ENSMUSG00000085604 
                 predicted 
                 6.6106867 
                 1.1279377 
                 −5.482749 
                 6.6106867 
               
               
                   
                   
                   
                 gene 11547 
               
               
                 Il18rap 
                 1.85857E−05 
                 ENSMUSG00000026068 
                 interleukin 18 
                 6.6765883 
                 2.3458426 
                 −4.3307457 
                 6.6765883 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                   
                   
                 accessory 
               
               
                   
                   
                   
                 protein 
               
               
                 2010002M12Rik 
                 0.000675854 
                 ENSMUSG00000067297 
                 RIKEN cDNA 
                 6.7453361 
                 1.2625871 
                 −5.482749 
                 6.7453361 
               
               
                   
                   
                   
                 2010002M12 
               
               
                   
                   
                   
                 gene 
               
               
                 Batf 
                 0.00066985 
                 ENSMUSG00000034266 
                 basic leucine 
                 6.75955 
                 1.276801 
                 −5.482749 
                 6.75955 
               
               
                   
                   
                   
                 zipper 
               
               
                   
                   
                   
                 transcription 
               
               
                   
                   
                   
                 factor, ATF- 
               
               
                   
                   
                   
                 like 
               
               
                 Irg1 
                 3.31171E−11 
                 ENSMUSG00000022126 
                 immunoresponsive 
                 6.81480982 
                 6.3420453 
                 −0.4727645 
                 6.81480982 
               
               
                   
                   
                   
                 gene 1 
               
               
                 Serinc2 
                 0.000244017 
                 ENSMUSG00000023232 
                 serine 
                 6.8737206 
                 3.1279376 
                 −3.745783 
                 6.8737206 
               
               
                   
                   
                   
                 incorporator 2 
               
               
                 Csf3 
                 0.001778822 
                 ENSMUSG00000038067 
                 colony 
                 6.9351213 
                 1.6043756 
                 −5.3307457 
                 6.9351213 
               
               
                   
                   
                   
                 stimulating 
               
               
                   
                   
                   
                 factor 3 
               
               
                   
                   
                   
                 (granulocyte) 
               
               
                 Gm14275 
                 0.001133265 
                 ENSMUSG00000085949 
                 predicted 
                 6.9451056 
                 1.4623566 
                 −5.482749 
                 6.9451056 
               
               
                   
                   
                   
                 gene 14275 
               
               
                 H28 
                 1.20005E−05 
                 ENSMUSG00000039146 
                 histocompatibility 
                 6.9781485 
                 4.647403 
                 −2.3307455 
                 6.9781485 
               
               
                   
                   
                   
                 28 
               
               
                 Gm11709 
                 0.001331092 
                 ENSMUSG00000089753 
                 predicted 
                 7.0012106 
                 1.6704649 
                 −5.3307457 
                 7.0012106 
               
               
                   
                   
                   
                 gene 11709 
               
               
                 Cxcl2 
                 6.37467E−06 
                 ENSMUSG00000058427 
                 chemokine 
                 7.0361591 
                 4.5127683 
                 −2.5233908 
                 7.0361591 
               
               
                   
                   
                   
                 (C—X—C motif) 
               
               
                   
                   
                   
                 ligand 2 
               
               
                 Gm8979 
                 0.000989941 
                 ENSMUSG00000091928 
                 predicted 
                 7.226676 
                 1.743927 
                 −5.482749 
                 7.226676 
               
               
                   
                   
                   
                 gene 8979 
               
               
                 Gm8989 
                 0.001071625 
                 ENSMUSG00000091567 
                 predicted 
                 7.226676 
                 1.743927 
                 −5.482749 
                 7.226676 
               
               
                   
                   
                   
                 gene 8989 
               
               
                 Lgals9 
                 1.50607E−06 
                 ENSMUSG00000001123 
                 lectin, 
                 7.357186 
                 4.611403 
                 −2.745783 
                 7.357186 
               
               
                   
                   
                   
                 galactose 
               
               
                   
                   
                   
                 binding, 
               
               
                   
                   
                   
                 soluble 9 
               
               
                 Rsad2 
                 2.21866E−08 
                 ENSMUSG00000020641 
                 radical S- 
                 7.438284 
                 5.692501 
                 −1.745783 
                 7.438284 
               
               
                   
                   
                   
                 adenosyl 
               
               
                   
                   
                   
                 methionine 
               
               
                   
                   
                   
                 domain 
               
               
                   
                   
                   
                 containing 2 
               
               
                 Oasl2 
                 0.000192137 
                 ENSMUSG00000029561 
                 2′-5′ 
                 7.5275784 
                 2.1968327 
                 −5.3307457 
                 7.5275784 
               
               
                   
                   
                   
                 oligoadenylate 
               
               
                   
                   
                   
                 synthetase- 
               
               
                   
                   
                   
                 like 2 
               
               
                 Zfp811 
                 0.00022262 
                 ENSMUSG00000055202 
                 zinc finger 
                 7.5869706 
                 2.1042216 
                 −5.482749 
                 7.5869706 
               
               
                   
                   
                   
                 protein 811 
               
               
                 Lancl3 
                 1.56193E−05 
                 ENSMUSG00000047344 
                 LanC 
                 7.7806113 
                 2.4498656 
                 −5.3307457 
                 7.7806113 
               
               
                   
                   
                   
                 lantibiotic 
               
               
                   
                   
                   
                 synthetase 
               
               
                   
                   
                   
                 component 
               
               
                   
                   
                   
                 C-like 3 
               
               
                   
                   
                   
                 (bacterial) 
               
               
                 Ppfibp2 
                 1.1878E−06 
                 ENSMUSG00000036528 
                 PTPRF 
                 7.8349816 
                 5.0891986 
                 −2.745783 
                 7.8349816 
               
               
                   
                   
                   
                 interacting 
               
               
                   
                   
                   
                 protein, 
               
               
                   
                   
                   
                 binding 
               
               
                   
                   
                   
                 protein 2 
               
               
                   
                   
                   
                 (liprin beta 2) 
               
               
                 Mx2 
                 2.73356E−05 
                 ENSMUSG00000023341 
                 myxovirus 
                 7.8539847 
                 2.523239 
                 −5.3307457 
                 7.8539847 
               
               
                   
                   
                   
                 (influenza 
               
               
                   
                   
                   
                 virus) 
               
               
                   
                   
                   
                 resistance 2 
               
               
                 Pou2f2 
                 5.15218E−06 
                 ENSMUSG00000008496 
                 POU domain, 
                 8.2065845 
                 2.8758388 
                 −5.3307457 
                 8.2065845 
               
               
                   
                   
                   
                 class 2, 
               
               
                   
                   
                   
                 transcription 
               
               
                   
                   
                   
                 factor 2 
               
               
                 Ifit1 
                 8.33396E−06 
                 ENSMUSG00000034459 
                 interferon- 
                 8.227443 
                 3.8966973 
                 −4.3307457 
                 8.227443 
               
               
                   
                   
                   
                 induced 
               
               
                   
                   
                   
                 protein with 
               
               
                   
                   
                   
                 tetratricopeptide 
               
               
                   
                   
                   
                 repeats 1 
               
               
                 Nos2 
                 2.15861E−09 
                 ENSMUSG00000020826 
                 nitric oxide 
                 8.6715229 
                 6.3407774 
                 −2.3307455 
                 8.6715229 
               
               
                   
                   
                   
                 synthase 2, 
               
               
                   
                   
                   
                 inducible 
               
               
                 Fcgr1 
                 1.58442E−08 
                 ENSMUSG00000015947 
                 Fc receptor, 
                 8.9574893 
                 3.4747403 
                 −5.482749 
                 8.9574893 
               
               
                   
                   
                   
                 IgG, high 
               
               
                   
                   
                   
                 affinity I 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 log 2  normalized 
               
               
                 Read count 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                   
                   
                 NCsh 
                 NCsh 
                 MMP-9sh 
                 MMP-9sh 
                   
                 log 2  ratio NCsh 
               
               
                 Peak 
                 Gene 
                 (N) 
                 (C) 
                 (N) 
                 (C) 
                 Input 
                 (N) vs input 
               
               
                   
               
            
           
           
               
            
               
                 Promoter Cleavage 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Chr1:129640001- 
                 Acmsd 
                 3.452 
                 3.345 
                 3.723 
                 4.892 
                 4.644 
                 −1.192 
               
               
                 129641000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:130156001- 
                 Ubxn4 
                 2.867 
                 3.831 
                 4.045 
                 3.754 
                 3.907 
                 −1.040 
               
               
                 130157000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:132640001- 
                 AA986860 
                 2.452 
                 3.345 
                 3.308 
                 4.240 
                 3.585 
                 −1.133 
               
               
                 132641000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:132971001- 
                 Mapkapk2 
                 2.867 
                 4.608 
                 3.308 
                 4.602 
                 3.907 
                 −1.040 
               
               
                 132972000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:134423001- 
                 Cntn2 
                 1.867 
                 1.023 
                 4.308 
                 1.433 
                 3.459 
                 −1.592 
               
               
                 134424000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:135147001- 
                 Plekha6 
                 2.452 
                 3.608 
                 3.308 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 135148000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:136022001- 
                 Chit1 
                 3.189 
                 4.193 
                 4.893 
                 4.754 
                 4.585 
                 −1.396 
               
               
                 136023000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:155379001- 
                 Npl 
                 1.867 
                 4.345 
                 2.723 
                 3.017 
                 3.322 
                 −1.455 
               
               
                 155380000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:173073001- 
                 Sdhc 
                 2.452 
                 3.608 
                 3.308 
                 4.433 
                 4.000 
                 −1.548 
               
               
                 173074000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:175560001- 
                 Pyhin1 
                 1.867 
                 4.608 
                 3.723 
                 2.433 
                 3.700 
                 −1.833 
               
               
                 175561000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:179681001- 
                 1700016C15Rik 
                 2.867 
                 4.345 
                 4.723 
                 3.433 
                 4.248 
                 −1.381 
               
               
                 179682000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:182164001- 
                 Psen2 
                 2.867 
                 3.023 
                 3.723 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 182165000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:184064001- 
                 Srp9 
                 2.867 
                 3.831 
                 3.723 
                 4.240 
                 4.170 
                 −1.303 
               
               
                 184065000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:188482001- 
                 Tgfb2 
                 1.867 
                 3.608 
                 1.723 
                 3.433 
                 3.807 
                 −1.940 
               
               
                 188483000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:193904001- 
                 Traf5 
                 1.867 
                 3.345 
                 2.723 
                 3.017 
                 3.807 
                 −1.940 
               
               
                 193905000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:74383001- 
                 Pnkd 
                 2.867 
                 3.345 
                 3.723 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 74384000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:87941001- 
                 2810459M11Rik 
                 2.452 
                 3.345 
                 3.723 
                 3.754 
                 4.000 
                 −1.548 
               
               
                 87942000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:89474001- 
                 Neu2 
                 3.452 
                 4.345 
                 5.308 
                 3.017 
                 4.524 
                 −1.072 
               
               
                 89475000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:90985001- 
                 Sh3bp4 
                 1.867 
                 3.345 
                 1.723 
                 3.433 
                 3.000 
                 −1.133 
               
               
                 90986000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:126473001- 
                 Fam119b 
                 2.452 
                 3.345 
                 4.045 
                 3.017 
                 3.459 
                 −1.007 
               
               
                 126474000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:127188001- 
                 Gpr182 
                 1.867 
                 4.193 
                 3.308 
                 4.240 
                 3.907 
                 −2.040 
               
               
                 127189000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:127669001- 
                 Gm17292 
                 0.867 
                 3.608 
                 1.723 
                 3.433 
                 2.000 
                 −1.133 
               
               
                 127670000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:127719001- 
                 Stat2 
                 3.189 
                 3.023 
                 3.308 
                 4.892 
                 4.322 
                 −1.133 
               
               
                 127720000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:127753001- 
                 Pan2 
                 1.867 
                 2.608 
                 3.308 
                 4.017 
                 3.322 
                 −1.455 
               
               
                 127754000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:128362001- 
                 Bloc1s1 
                 2.452 
                 2.023 
                 4.308 
                 3.754 
                 4.392 
                 −1.940 
               
               
                 128363000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:18728001- 
                 Tnfaip3 
                 2.452 
                 3.345 
                 3.308 
                 4.017 
                 4.248 
                 −1.796 
               
               
                 18729000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:39706001- 
                 BC021785 
                 2.452 
                 3.608 
                 3.308 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 39707000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:79539001- 
                 Sbno2 
                 2.867 
                 3.345 
                 1.723 
                 4.754 
                 4.087 
                 −1.220 
               
               
                 79540000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:80327001- 
                 3110056O03Rik 
                 2.452 
                 2.023 
                 3.723 
                 3.754 
                 3.585 
                 −1.133 
               
               
                 80328000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:80619001- 
                 Pias4 
                 1.867 
                 3.608 
                 3.308 
                 2.433 
                 4.000 
                 −2.133 
               
               
                 80620000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:80643001- 
                 Eef2 
                 2.452 
                 3.345 
                 3.723 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 80644000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:83993001- 
                 Ckap4 
                 2.452 
                 2.608 
                 4.045 
                 4.602 
                 3.585 
                 −1.133 
               
               
                 83994000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:95254001- 
                 4732465J04Rik 
                 2.867 
                 4.608 
                 4.723 
                 3.433 
                 4.170 
                 −1.303 
               
               
                 95255000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:105800001- 
                 Cyb561 
                 2.452 
                 3.345 
                 1.571 
                 4.754 
                 3.585 
                 −1.133 
               
               
                 105801000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:113519001- 
                 Cog1 
                 0.867 
                 4.023 
                 2.723 
                 3.433 
                 2.000 
                 −1.133 
               
               
                 113520000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:11402001- 
                 4930415F15Rik 
                 2.867 
                 4.023 
                 3.308 
                 4.433 
                 3.907 
                 −1.040 
               
               
                 11403000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:114860001- 
                 AF251705 
                 0.867 
                 3.345 
                 2.723 
                 4.017 
                 3.170 
                 −2.303 
               
               
                 114861000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:115269001- 
                 Ict1 
                 2.452 
                 4.023 
                 3.723 
                 3.754 
                 3.907 
                 −1.455 
               
               
                 115270000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:115756001- 
                 Recql5 
                 2.867 
                 3.608 
                 3.723 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 115757000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:116715001- 
                 1110005A03Rik 
                 2.452 
                 4.023 
                 4.531 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 116716000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:120209001- 
                 Actg1 
                 1.867 
                 3.023 
                 1.723 
                 3.433 
                 3.170 
                 −1.303 
               
               
                 120210000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:120807001- 
                 Slc16a3 
                 1.867 
                 3.345 
                 4.308 
                 4.017 
                 3.322 
                 −1.455 
               
               
                 120808000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:20235001- 
                 Gm12033 
                 2.452 
                 3.608 
                 3.308 
                 3.754 
                 4.807 
                 −2.355 
               
               
                 20236000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:4600001- 
                 Uqcr10 
                 2.867 
                 3.345 
                 1.723 
                 4.602 
                 4.000 
                 −1.133 
               
               
                 4601000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:48668001- 
                 Gm16170 
                 2.867 
                 4.023 
                 4.723 
                 4.892 
                 4.248 
                 −1.381 
               
               
                 48669000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:50020001- 
                 Sqstm1 
                 2.452 
                 3.023 
                 3.723 
                 3.754 
                 3.585 
                 −1.133 
               
               
                 50021000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:53698001- 
                 Slc22a5 
                 1.867 
                 2.023 
                 1.723 
                 3.433 
                 3.907 
                 −2.040 
               
               
                 53699000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:5423001- 
                 Xbp1 
                 2.452 
                 4.193 
                 4.308 
                 4.240 
                 3.807 
                 −1.355 
               
               
                 5424000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:54967001- 
                 Slc36a3 
                 2.452 
                 3.608 
                 4.045 
                 3.017 
                 3.700 
                 −1.248 
               
               
                 54968000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:55071001- 
                 Fat2 
                 2.867 
                 4.023 
                 1.571 
                 4.754 
                 4.087 
                 −1.220 
               
               
                 55072000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:55268001- 
                 Atox1 
                 1.867 
                 3.345 
                 3.723 
                 1.433 
                 3.807 
                 −1.940 
               
               
                 55269000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:58748001- 
                 Rnf187 
                 2.867 
                 4.193 
                 3.723 
                 4.017 
                 4.087 
                 −1.220 
               
               
                 58749000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:61037001- 
                 Aldh3a2 
                 2.867 
                 3.831 
                 3.308 
                 4.240 
                 4.000 
                 −1.133 
               
               
                 61038000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:61368001- 
                 Epn2 
                 2.867 
                 3.608 
                 3.308 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 61369000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:61523001- 
                 Slc5a10 
                 2.867 
                 3.831 
                 4.308 
                 3.433 
                 3.907 
                 −1.040 
               
               
                 61524000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:62119001- 
                 Ttc19 
                 3.189 
                 3.831 
                 4.531 
                 4.017 
                 4.248 
                 −1.059 
               
               
                 62120000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:62467001- 
                 Mmgt2 
                 2.452 
                 3.023 
                 3.308 
                 4.240 
                 3.907 
                 −1.455 
               
               
                 62468000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:6381001- 
                 Gm11973 
                 1.867 
                 3.023 
                 3.308 
                 3.754 
                 3.807 
                 −1.940 
               
               
                 6382000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:69468001- 
                 Sox15 
                 2.452 
                 2.608 
                 4.531 
                 2.433 
                 4.170 
                 −1.718 
               
               
                 69469000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:69660001- 
                 Plscr3 
                 1.867 
                 3.345 
                 3.723 
                 3.433 
                 3.170 
                 −1.303 
               
               
                 69661000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:76842001- 
                 Slc6a4 
                 1.867 
                 3.345 
                 1.723 
                 3.433 
                 3.807 
                 −1.940 
               
               
                 76843000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:77314001- 
                 Git1 
                 2.452 
                 4.345 
                 5.045 
                 3.754 
                 3.700 
                 −1.248 
               
               
                 77315000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:82996001- 
                 Slfn4 
                 2.867 
                 4.345 
                 3.723 
                 4.433 
                 4.000 
                 −1.133 
               
               
                 82997000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:87493001- 
                 Rnf43 
                 2.867 
                 3.023 
                 3.723 
                 4.017 
                 4.644 
                 −1.777 
               
               
                 87494000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:88591001- 
                 C030037D09Rik 
                 2.452 
                 2.023 
                 3.308 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 88592000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:95724001- 
                 4833417C18Rik 
                 1.867 
                 4.608 
                 2.723 
                 4.240 
                 3.700 
                 −1.833 
               
               
                 95725000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:95903001- 
                 Snf8 
                 2.867 
                 2.608 
                 3.723 
                 4.754 
                 4.000 
                 −1.133 
               
               
                 95904000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:95910001- 
                 Ube2z 
                 2.867 
                 4.193 
                 3.308 
                 4.240 
                 4.087 
                 −1.220 
               
               
                 95911000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:96710001- 
                 Copz2 
                 2.452 
                 3.345 
                 4.045 
                 3.017 
                 3.907 
                 −1.455 
               
               
                 96711000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:102171001- 
                 Ccdc88c 
                 2.867 
                 4.023 
                 3.308 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 102172000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:112921001- 
                 Trmt61a 
                 1.867 
                 3.608 
                 3.308 
                 3.017 
                 3.807 
                 −1.940 
               
               
                 112922000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:113739001- 
                 Tmem179 
                 1.867 
                 4.023 
                 1.723 
                 4.240 
                 3.907 
                 −2.040 
               
               
                 113740000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:17888001- 
                 Gm9222 
                 1.867 
                 3.023 
                 1.723 
                 3.433 
                 4.000 
                 −2.133 
               
               
                 17889000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:17933001- 
                 B430203G13Rik 
                 1.867 
                 3.608 
                 3.723 
                 3.754 
                 4.459 
                 −2.592 
               
               
                 17934000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:27159001- 
                 Cmpk2 
                 2.452 
                 3.608 
                 3.723 
                 3.433 
                 3.585 
                 −1.133 
               
               
                 27160000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:82636001- 
                 6530401F13Rik 
                 2.452 
                 3.608 
                 4.045 
                 3.754 
                 3.700 
                 −1.248 
               
               
                 82637000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:85359001- 
                 Acot1 
                 2.452 
                 3.608 
                 4.045 
                 4.017 
                 4.524 
                 −2.072 
               
               
                 85360000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:86814001- 
                 Fos 
                 2.452 
                 3.345 
                 4.045 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 86815000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:104825001- 
                 Nln 
                 1.867 
                 4.023 
                 3.308 
                 2.433 
                 4.087 
                 −2.220 
               
               
                 104826000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:34334001- 
                 Slc22a23 
                 2.867 
                 3.831 
                 4.308 
                 3.433 
                 3.907 
                 −1.040 
               
               
                 34335000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:54890001- 
                 Tspan17 
                 2.452 
                 3.345 
                 3.723 
                 3.433 
                 3.700 
                 −1.248 
               
               
                 54891000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:55882001- 
                 4930451E10Rik 
                 3.452 
                 4.608 
                 5.045 
                 4.017 
                 4.700 
                 −1.248 
               
               
                 55883000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:65364001- 
                 Gm10775 
                 1.867 
                 3.345 
                 2.723 
                 3.017 
                 3.322 
                 −1.455 
               
               
                 65365000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:70147001- 
                 Gm6132 
                 1.867 
                 3.345 
                 1.571 
                 4.017 
                 3.170 
                 −1.303 
               
               
                 70148000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:74444001- 
                 Pdcd6 
                 0.867 
                 3.831 
                 4.531 
                 3.017 
                 3.700 
                 −2.833 
               
               
                 74445000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:8940001- 
                 Rpl10a-ps2 
                 2.452 
                 3.023 
                 4.045 
                 4.602 
                 3.700 
                 −1.248 
               
               
                 8941000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:8955001- 
                 Idi2 
                 0.867 
                 3.345 
                 3.723 
                 4.017 
                 3.000 
                 −2.133 
               
               
                 8956000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:94943001- 
                 Lhfpl2 
                 1.867 
                 4.023 
                 2.723 
                 3.017 
                 3.585 
                 −1.718 
               
               
                 94944000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:96004001- 
                 Pde8b 
                 2.867 
                 0.871 
                 3.723 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 96005000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:20414001- 
                 Gm5458 
                 2.452 
                 4.023 
                 4.045 
                 3.754 
                 4.170 
                 −1.718 
               
               
                 20415000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:25130001- 
                 E330034G19Rik 
                 2.452 
                 3.345 
                 4.045 
                 3.017 
                 4.000 
                 −1.548 
               
               
                 25131000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:31752001- 
                 Itih1 
                 2.867 
                 3.023 
                 2.723 
                 4.602 
                 4.000 
                 −1.133 
               
               
                 31753000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:4733001- 
                 Gm8159 
                 2.452 
                 4.831 
                 4.308 
                 3.017 
                 4.000 
                 −1.548 
               
               
                 4734000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:47392001- 
                 Cdkn3 
                 2.867 
                 4.023 
                 3.723 
                 4.017 
                 4.000 
                 −1.133 
               
               
                 47393000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:55248001- 
                 Psmb11 
                 3.189 
                 1.023 
                 4.045 
                 4.433 
                 4.248 
                 −1.059 
               
               
                 55249000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:55260001- 
                 Cdh24 
                 1.867 
                 3.608 
                 2.723 
                 3.017 
                 3.000 
                 −1.133 
               
               
                 55261000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:55473001- 
                 Homez 
                 0.867 
                 4.193 
                 4.045 
                 3.017 
                 3.585 
                 −2.718 
               
               
                 55474000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:59880001- 
                 Gm6904 
                 1.867 
                 4.345 
                 4.308 
                 3.433 
                 3.585 
                 −1.718 
               
               
                 59881000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:59986001- 
                 D14Ertd668e 
                 2.452 
                 4.023 
                 4.308 
                 4.017 
                 3.807 
                 −1.355 
               
               
                 59987000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:62086001- 
                 Rps12-ps2 
                 2.452 
                 3.023 
                 4.308 
                 4.017 
                 3.907 
                 −1.455 
               
               
                 62087000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:8296001- 
                 Gm3752 
                 2.867 
                 3.345 
                 3.723 
                 4.017 
                 4.000 
                 −1.133 
               
               
                 8297000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:8390001- 
                 Gm3558 
                 2.867 
                 3.608 
                 4.045 
                 3.754 
                 3.907 
                 −1.040 
               
               
                 8391000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:101942001- 
                 Tenc1 
                 1.867 
                 3.608 
                 3.723 
                 2.433 
                 3.000 
                 −1.133 
               
               
                 101943000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:10441001- 
                 Ttc23l 
                 1.867 
                 4.023 
                 1.723 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 10442000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:52159001- 
                 Slc30a8 
                 2.452 
                 4.345 
                 4.045 
                 3.017 
                 3.700 
                 −1.248 
               
               
                 52160000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:73341001- 
                 Dennd3 
                 2.867 
                 2.608 
                 4.045 
                 3.754 
                 4.585 
                 −1.718 
               
               
                 73342000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:74714001- 
                 2010109I03Rik 
                 2.452 
                 3.608 
                 4.045 
                 4.240 
                 3.585 
                 −1.133 
               
               
                 74715000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:79783001- 
                 Cbx7 
                 1.867 
                 3.023 
                 3.308 
                 2.433 
                 3.459 
                 −1.592 
               
               
                 79784000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:85660001- 
                 Ttc38 
                 1.867 
                 1.023 
                 2.723 
                 3.017 
                 3.807 
                 −1.940 
               
               
                 85661000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:88950001- 
                 Tubgcp6 
                 1.867 
                 3.608 
                 4.045 
                 3.754 
                 3.700 
                 −1.833 
               
               
                 88951000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:9054001- 
                 Skp2 
                 2.452 
                 3.608 
                 4.045 
                 3.433 
                 4.087 
                 −1.635 
               
               
                 9055000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:11128001- 
                 Txndc11 
                 2.867 
                 4.483 
                 3.308 
                 4.240 
                 4.087 
                 −1.220 
               
               
                 11129000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:16417001- 
                 Fgd4 
                 2.867 
                 3.023 
                 3.723 
                 4.017 
                 4.170 
                 −1.303 
               
               
                 16418000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:18632001- 
                 SEPT_5 
                 2.452 
                 4.023 
                 4.045 
                 4.017 
                 3.459 
                 −1.007 
               
               
                 18633000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:32683001- 
                 Tnk2 
                 2.867 
                 4.023 
                 4.045 
                 3.754 
                 4.000 
                 −1.133 
               
               
                 32684000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:38321001- 
                 4932425I24Rik 
                 2.452 
                 3.023 
                 3.723 
                 4.017 
                 3.585 
                 −1.133 
               
               
                 38322000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:44176001- 
                 Gm608 
                 2.867 
                 4.930 
                 3.723 
                 4.017 
                 4.087 
                 −1.220 
               
               
                 44177000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:77117001- 
                 Usp25 
                 3.452 
                 3.831 
                 4.531 
                 4.433 
                 4.954 
                 −1.502 
               
               
                 77118000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:85795001- 
                 Adamts1 
                 2.867 
                 4.023 
                 2.723 
                 4.754 
                 3.907 
                 −1.040 
               
               
                 85796000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:8850001- 
                 1810013L24Rik 
                 2.452 
                 4.345 
                 3.308 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 8851000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:93610001- 
                 Cbr1 
                 2.867 
                 4.193 
                 4.531 
                 3.754 
                 4.170 
                 −1.303 
               
               
                 93611000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:94735001- 
                 Dscr3 
                 2.867 
                 4.023 
                 3.723 
                 4.017 
                 4.000 
                 −1.133 
               
               
                 94736000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:21685001- 
                 Zfp52 
                 3.452 
                 4.023 
                 4.531 
                 4.433 
                 4.700 
                 −1.248 
               
               
                 21686000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:24229001- 
                 Pdpk1 
                 2.452 
                 4.483 
                 2.723 
                 4.017 
                 3.459 
                 −1.007 
               
               
                 24230000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:24373001- 
                 Ccnf 
                 3.189 
                 1.023 
                 2.723 
                 5.133 
                 4.322 
                 −1.133 
               
               
                 24374000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:24873001- 
                 Rpl3l 
                 1.867 
                 3.023 
                 3.308 
                 3.754 
                 3.459 
                 −1.592 
               
               
                 24874000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:27033001- 
                 Gm20468 
                 2.452 
                 3.023 
                 4.308 
                 4.017 
                 3.459 
                 −1.007 
               
               
                 27034000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:27740001- 
                 Nudt3 
                 3.452 
                 3.608 
                 4.045 
                 5.017 
                 4.524 
                 −1.072 
               
               
                 27741000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:27816001- 
                 Pacsin1 
                 1.867 
                 4.023 
                 2.723 
                 3.017 
                 3.459 
                 −1.592 
               
               
                 27817000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:34072001- 
                 Rgl2 
                 0.867 
                 3.345 
                 2.723 
                 2.433 
                 3.807 
                 −2.940 
               
               
                 34073000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:35619001- 
                 Gm20419 
                 2.452 
                 3.608 
                 3.723 
                 3.754 
                 4.322 
                 −1.870 
               
               
                 35620000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:37004001- 
                 Trim15 
                 1.867 
                 3.345 
                 2.723 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 37005000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:48573001- 
                 Apobec2 
                 0.715 
                 3.023 
                 1.723 
                 4.240 
                 3.000 
                 −2.285 
               
               
                 48574000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:53812001- 
                 Kat2b 
                 1.867 
                 2.608 
                 2.723 
                 3.017 
                 3.322 
                 −1.455 
               
               
                 53813000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:57010001- 
                 Acsbg2 
                 1.867 
                 3.608 
                 1.723 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 57011000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:57392001- 
                 Trip10 
                 2.452 
                 3.023 
                 4.723 
                 2.433 
                 3.700 
                 −1.248 
               
               
                 57393000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:66342001- 
                 Ankrd12 
                 1.867 
                 3.345 
                 1.571 
                 3.754 
                 3.000 
                 −1.133 
               
               
                 66343000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:6857001- 
                 Dynlt1e 
                 2.452 
                 3.608 
                 4.045 
                 3.754 
                 3.700 
                 −1.248 
               
               
                 6858000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:71251001- 
                 Gm16627 
                 2.867 
                 3.831 
                 4.045 
                 3.754 
                 3.907 
                 −1.040 
               
               
                 71252000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:80944001- 
                 Cdkl4 
                 1.867 
                 3.345 
                 3.723 
                 1.433 
                 3.459 
                 −1.592 
               
               
                 80945000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:8170001- 
                 Rsph3a 
                 1.867 
                 3.831 
                 3.308 
                 2.433 
                 3.807 
                 −1.940 
               
               
                 8171000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:85187001- 
                 Lrpprc 
                 2.867 
                 3.831 
                 4.308 
                 3.433 
                 3.907 
                 −1.040 
               
               
                 85188000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:35942001- 
                 Ube2d2 
                 2.452 
                 4.023 
                 1.723 
                 4.240 
                 3.459 
                 −1.007 
               
               
                 35943000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:37655001- 
                 Pcdhb19 
                 2.452 
                 3.023 
                 1.723 
                 4.602 
                 3.700 
                 −1.248 
               
               
                 37656000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:50200001- 
                 Tnfaip8 
                 2.867 
                 3.831 
                 3.723 
                 4.017 
                 4.000 
                 −1.133 
               
               
                 50201000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:57047001- 
                 MARCH_3 
                 2.452 
                 4.483 
                 4.308 
                 3.017 
                 3.700 
                 −1.248 
               
               
                 57048000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:60427001- 
                 Gm4841 
                 2.452 
                 3.345 
                 4.045 
                 4.017 
                 4.000 
                 −1.548 
               
               
                 60428000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:74948001- 
                 Acaa2 
                 2.452 
                 3.023 
                 3.723 
                 3.433 
                 4.170 
                 −1.718 
               
               
                 74949000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:80213001- 
                 Gm10527 
                 2.452 
                 0.871 
                 3.308 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 80214000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:80911001- 
                 Nfatc1 
                 0.867 
                 3.860 
                 2.723 
                 3.433 
                 3.170 
                 −2.303 
               
               
                 80812000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:10603001- 
                 Cpsf7 
                 2.867 
                 3.023 
                 3.308 
                 4.602 
                 3.907 
                 −1.040 
               
               
                 10604000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:11531001- 
                 Ms4a4b 
                 2.867 
                 3.831 
                 5.531 
                 3.017 
                 3.907 
                 −1.040 
               
               
                 11532000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:11848001- 
                 Mrpl16 
                 1.867 
                 2.608 
                 4.308 
                 2.433 
                 3.322 
                 −1.455 
               
               
                 11849000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:23147001- 
                 C330002G04Rik 
                 2.452 
                 3.345 
                 2.723 
                 4.017 
                 3.585 
                 −1.133 
               
               
                 23148000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:29102001- 
                 Ak3 
                 2.452 
                 4.345 
                 3.308 
                 4.017 
                 3.807 
                 −1.355 
               
               
                 29103000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:41984001- 
                 Pgam1 
                 1.867 
                 4.193 
                 1.723 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 41985000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:42219001- 
                 Marveld1 
                 3.189 
                 3.831 
                 3.723 
                 4.602 
                 4.392 
                 −1.203 
               
               
                 42220000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:4234001- 
                 Pold4 
                 1.867 
                 3.608 
                 2.723 
                 3.017 
                 3.459 
                 −1.592 
               
               
                 4235000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:47606001- 
                 Obfc1 
                 1.867 
                 4.193 
                 3.308 
                 2.433 
                 3.322 
                 −1.455 
               
               
                 47607000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:5418001- 
                 4930481A15Rik 
                 2.452 
                 3.831 
                 4.045 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 5419000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:5600001- 
                 Rnaseh2c 
                 1.867 
                 4.483 
                 3.308 
                 4.017 
                 3.459 
                 −1.592 
               
               
                 5601000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:60628001- 
                 2700078E11Rik 
                 2.452 
                 4.345 
                 3.723 
                 3.754 
                 3.700 
                 −1.248 
               
               
                 60629000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:6064001- 
                 Tm7sf2 
                 2.867 
                 3.345 
                 4.045 
                 3.754 
                 4.000 
                 −1.133 
               
               
                 6065000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:6314001- 
                 Cdc42bpg 
                 0.867 
                 4.023 
                 3.308 
                 4.240 
                 3.000 
                 −2.133 
               
               
                 6315000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:7075001- 
                 Fermt3 
                 2.452 
                 4.345 
                 4.045 
                 3.017 
                 3.459 
                 −1.007 
               
               
                 7076000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:103928001- 
                 Cd59b 
                 3.189 
                 3.608 
                 3.723 
                 4.892 
                 4.585 
                 −1.396 
               
               
                 103929000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:112164001- 
                 Slc12a6 
                 2.867 
                 3.831 
                 4.308 
                 3.433 
                 4.807 
                 −1.940 
               
               
                 112165000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:117160001- 
                 Rasgrp1 
                 2.867 
                 3.023 
                 3.308 
                 4.433 
                 3.907 
                 −1.040 
               
               
                 117161000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:119428001- 
                 1700020I14Rik 
                 2.452 
                 2.608 
                 3.723 
                 4.433 
                 3.459 
                 −1.007 
               
               
                 119429000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:126901001- 
                 Blvra 
                 2.867 
                 4.023 
                 3.723 
                 4.017 
                 5.392 
                 −2.525 
               
               
                 126902000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:152565001- 
                 Id1 
                 1.867 
                 2.608 
                 3.723 
                 3.017 
                 3.000 
                 −1.133 
               
               
                 152566000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:154497001- 
                 Chmp4b 
                 2.867 
                 4.023 
                 4.308 
                 3.433 
                 4.248 
                 −1.381 
               
               
                 154498000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:155358001- 
                 Acss2 
                 2.867 
                 3.608 
                 3.308 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 155359000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:155416001- 
                 Gss 
                 2.452 
                 3.608 
                 3.723 
                 4.017 
                 4.000 
                 −1.548 
               
               
                 155417000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:156658001- 
                 Gm14230 
                 0.867 
                 4.193 
                 3.308 
                 4.602 
                 2.000 
                 −1.133 
               
               
                 156659000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:158083001- 
                 Bpi 
                 0.867 
                 3.023 
                 2.723 
                 3.017 
                 3.807 
                 −2.940 
               
               
                 158084000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:164300001- 
                 Sys1 
                 3.189 
                 4.193 
                 4.308 
                 4.433 
                 4.322 
                 −1.133 
               
               
                 164301000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:164595001- 
                 Gm11457 
                 1.867 
                 3.608 
                 1.723 
                 4.602 
                 3.000 
                 −1.133 
               
               
                 164596000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:167439001- 
                 Ube2v1 
                 2.452 
                 3.023 
                 2.723 
                 4.017 
                 3.585 
                 −1.133 
               
               
                 167440000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:172260001- 
                 Gm14455 
                 1.867 
                 5.023 
                 4.045 
                 2.433 
                 3.585 
                 −1.718 
               
               
                 172261000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:17959001- 
                 A930004D18Rik 
                 0.867 
                 2.608 
                 3.308 
                 3.433 
                 3.459 
                 −2.592 
               
               
                 17960000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:21137001- 
                 Thnsl1 
                 2.452 
                 4.608 
                 4.531 
                 2.433 
                 3.459 
                 −1.007 
               
               
                 21138000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:24198001- 
                 Il1rn 
                 2.867 
                 4.608 
                 4.531 
                 4.240 
                 4.087 
                 −1.220 
               
               
                 24199000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:25034001- 
                 Nrarp 
                 1.867 
                 2.608 
                 2.723 
                 4.017 
                 3.459 
                 −1.592 
               
               
                 25035000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:26800001- 
                 Gm711 
                 2.452 
                 3.831 
                 3.723 
                 3.433 
                 4.644 
                 −2.192 
               
               
                 26801000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:26870001- 
                 5930434B04Rik 
                 2.452 
                 3.608 
                 3.723 
                 3.433 
                 3.807 
                 −1.355 
               
               
                 26871000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:30817001- 
                 Tor1a 
                 1.867 
                 3.831 
                 3.308 
                 3.017 
                 3.700 
                 −1.833 
               
               
                 30818000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:3231001- 
                 Nmt2 
                 1.867 
                 4.023 
                 3.308 
                 2.433 
                 3.000 
                 −1.133 
               
               
                 3232000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:33583001- 
                 Fam125b 
                 1.867 
                 4.193 
                 3.308 
                 2.433 
                 3.322 
                 −1.455 
               
               
                 33584000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:34532001- 
                 Gapvd1 
                 2.867 
                 4.724 
                 4.045 
                 3.754 
                 3.907 
                 −1.040 
               
               
                 34533000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:36078001- 
                 Gm13431 
                 1.867 
                 3.345 
                 3.723 
                 2.433 
                 3.000 
                 −1.133 
               
               
                 36079000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:38383001- 
                 Nek6 
                 1.867 
                 3.831 
                 3.308 
                 2.433 
                 3.322 
                 −1.455 
               
               
                 38384000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:56967001- 
                 Nr4a2 
                 1.867 
                 4.193 
                 1.723 
                 4.433 
                 3.000 
                 −1.133 
               
               
                 56968000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:60076001- 
                 MARCH_7 
                 2.867 
                 4.023 
                 3.723 
                 4.017 
                 4.000 
                 −1.133 
               
               
                 60077000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:84647001- 
                 Ube2l6 
                 0.715 
                 2.608 
                 2.723 
                 2.433 
                 2.807 
                 −2.092 
               
               
                 84648000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:90741001- 
                 Ndufs3 
                 1.867 
                 4.345 
                 2.723 
                 3.017 
                 3.322 
                 −1.455 
               
               
                 90742000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:90894001- 
                 Gm13778 
                 2.452 
                 4.023 
                 3.723 
                 3.433 
                 3.459 
                 −1.007 
               
               
                 90895000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:90910001- 
                 Slc39a13 
                 1.867 
                 3.608 
                 4.308 
                 1.280 
                 3.000 
                 −1.133 
               
               
                 90911000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:91154001- 
                 1110051M20Rik 
                 2.867 
                 3.023 
                 4.723 
                 2.433 
                 4.000 
                 −1.133 
               
               
                 91155000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:93026001- 
                 Trp53i11 
                 2.452 
                 4.023 
                 3.723 
                 3.433 
                 3.585 
                 −1.133 
               
               
                 93027000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:145309001- 
                 Cyr61 
                 2.452 
                 3.608 
                 2.723 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 145310000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:14610001- 
                 1810022K09Rik 
                 2.452 
                 3.608 
                 4.045 
                 3.754 
                 4.000 
                 −1.548 
               
               
                 14611000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:31061001- 
                 Cldn11 
                 1.867 
                 3.345 
                 2.723 
                 3.433 
                 3.000 
                 −1.133 
               
               
                 31062000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:32336001- 
                 Pik3ca 
                 1.867 
                 3.345 
                 3.723 
                 1.433 
                 3.170 
                 −1.303 
               
               
                 32337000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:33703001- 
                 Ttc14 
                 2.452 
                 3.831 
                 2.723 
                 4.017 
                 3.807 
                 −1.355 
               
               
                 33704000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:51236001- 
                 Naa15 
                 2.452 
                 4.023 
                 2.723 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 51237000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:90190001- 
                 Slc27a3 
                 2.867 
                 4.023 
                 4.531 
                 3.017 
                 4.392 
                 −1.525 
               
               
                 90191000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:90203001- 
                 Ints3 
                 3.452 
                 4.345 
                 4.045 
                 4.892 
                 4.524 
                 −1.072 
               
               
                 90204000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:107892001- 
                 Zyg11a 
                 2.452 
                 4.193 
                 4.045 
                 3.017 
                 3.807 
                 −1.355 
               
               
                 107893000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:116776001- 
                 Ptch2 
                 1.867 
                 3.345 
                 3.308 
                 2.433 
                 3.585 
                 −1.718 
               
               
                 116777000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:117548001- 
                 B4galt2 
                 1.867 
                 3.023 
                 1.723 
                 3.754 
                 4.000 
                 −2.133 
               
               
                 117549000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:119308001- 
                 Guca2a 
                 0.867 
                 4.345 
                 2.723 
                 2.433 
                 3.459 
                 −2.592 
               
               
                 119309000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:128582001- 
                 Trim62 
                 2.452 
                 4.193 
                 3.723 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 128583000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:143208001- 
                 Gm13083 
                 2.452 
                 3.831 
                 3.723 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 143209000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:143946001- 
                 Gm13119 
                 2.452 
                 3.345 
                 3.308 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 143947000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:14616001- 
                 Lrrc69 
                 3.189 
                 4.724 
                 4.308 
                 4.240 
                 4.322 
                 −1.133 
               
               
                 14617000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:149467001- 
                 Gpr157 
                 2.452 
                 2.023 
                 4.045 
                 3.433 
                 3.807 
                 −1.355 
               
               
                 149468000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:150276001- 
                 Park7 
                 2.867 
                 3.023 
                 3.308 
                 4.240 
                 4.000 
                 −1.133 
               
               
                 150277000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:19525001- 
                 Fam82b 
                 2.867 
                 3.831 
                 3.723 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 19526000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:40995001- 
                 Aqp7 
                 2.452 
                 4.345 
                 2.723 
                 4.240 
                 3.807 
                 −1.355 
               
               
                 40996000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:41472001- 
                 2310028H24Rik 
                 1.867 
                 4.345 
                 1.723 
                 3.754 
                 3.322 
                 −1.455 
               
               
                 41473000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:45357001- 
                 Dcaf10 
                 2.867 
                 3.345 
                 3.723 
                 4.017 
                 4.000 
                 −1.133 
               
               
                 45358000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:49546001- 
                 Zfp189 
                 2.452 
                 3.831 
                 3.723 
                 3.433 
                 3.700 
                 −1.248 
               
               
                 49547000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:53802001- 
                 Tal2 
                 2.867 
                 3.831 
                 4.893 
                 3.433 
                 4.087 
                 −1.220 
               
               
                 53803000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:63212001- 
                 Atp6v1g1 
                 2.452 
                 3.608 
                 1.723 
                 4.240 
                 3.459 
                 −1.007 
               
               
                 63213000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:72509001- 
                 Aldoart1 
                 2.452 
                 4.193 
                 2.723 
                 4.017 
                 4.000 
                 −1.548 
               
               
                 72510000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:83153001- 
                 Gm10154 
                 2.452 
                 1.023 
                 4.045 
                 3.017 
                 3.459 
                 −1.007 
               
               
                 83154000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:88362001- 
                 Klhl9 
                 1.867 
                 3.608 
                 4.531 
                 2.433 
                 3.700 
                 −1.833 
               
               
                 88363000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:104534001- 
                 Sparcl1 
                 2.867 
                 3.831 
                 3.723 
                 4.017 
                 4.000 
                 −1.133 
               
               
                 104535000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:105466001- 
                 Gbp8 
                 1.867 
                 4.193 
                 1.723 
                 3.433 
                 3.585 
                 −1.718 
               
               
                 105467000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:114456001- 
                 Dao 
                 1.867 
                 4.193 
                 1.723 
                 3.754 
                 3.700 
                 −1.833 
               
               
                 114457000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:115096001- 
                 Trpv4 
                 2.867 
                 3.831 
                 3.723 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 115097000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:115131001- 
                 Gltp 
                 2.452 
                 3.023 
                 4.531 
                 4.017 
                 3.459 
                 −1.007 
               
               
                 115132000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:116469001- 
                 Prkab1 
                 1.867 
                 4.608 
                 2.723 
                 4.433 
                 3.322 
                 −1.455 
               
               
                 116470000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:117813001- 
                 Wsb2 
                 1.867 
                 4.023 
                 3.723 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 117814000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:123492001- 
                 Morn3 
                 2.452 
                 3.831 
                 3.723 
                 3.754 
                 4.087 
                 −1.635 
               
               
                 123493000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:130681001- 
                 Rabgef1 
                 2.867 
                 3.608 
                 1.571 
                 4.892 
                 4.170 
                 −1.303 
               
               
                 130682000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:139875001- 
                 3110082I17Rik 
                 1.867 
                 3.831 
                 3.723 
                 2.433 
                 3.807 
                 −1.940 
               
               
                 139876000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:141212001- 
                 Amz1 
                 2.867 
                 4.193 
                 1.571 
                 4.754 
                 3.907 
                 −1.040 
               
               
                 141213000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:23883001- 
                 Nos3 
                 1.867 
                 3.831 
                 1.723 
                 4.017 
                 3.907 
                 −2.040 
               
               
                 23884000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:25007001- 
                 4831440E17Rik 
                 1.867 
                 1.023 
                 3.723 
                 4.240 
                 3.907 
                 −2.040 
               
               
                 25008000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:33372001- 
                 Ywhah 
                 2.867 
                 3.023 
                 5.045 
                 3.754 
                 4.000 
                 −1.133 
               
               
                 33373000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:36063001- 
                 Sh3tc1 
                 2.452 
                 3.345 
                 3.308 
                 3.754 
                 4.000 
                 −1.548 
               
               
                 36064000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:86518001- 
                 Stap1 
                 2.452 
                 3.023 
                 4.045 
                 3.017 
                 4.248 
                 −1.796 
               
               
                 86519000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:89861001- 
                 Gc 
                 3.452 
                 4.193 
                 5.183 
                 3.433 
                 5.615 
                 −2.163 
               
               
                 89862000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:95385001- 
                 Gm3176 
                 1.867 
                 4.345 
                 5.045 
                 4.017 
                 3.000 
                 −1.133 
               
               
                 95386000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:113425001- 
                 Il17rc 
                 2.452 
                 4.483 
                 4.723 
                 4.017 
                 3.907 
                 −1.455 
               
               
                 113426000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:113447001- 
                 Prrt3 
                 2.452 
                 3.345 
                 3.723 
                 4.017 
                 3.807 
                 −1.355 
               
               
                 113448000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:115898001- 
                 H1foo 
                 1.867 
                 3.831 
                 4.045 
                 3.017 
                 3.322 
                 −1.455 
               
               
                 115899000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:116456001- 
                 Olfr212 
                 2.452 
                 3.023 
                 3.723 
                 4.017 
                 3.807 
                 −1.355 
               
               
                 116457000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:116574001- 
                 Zfp422 
                 3.189 
                 3.345 
                 3.723 
                 5.017 
                 4.248 
                 −1.059 
               
               
                 116575000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:120774001- 
                 Atp6v1e1 
                 3.452 
                 5.271 
                 5.045 
                 4.017 
                 2.322 
                 1.130 
               
               
                 120775000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:125499001- 
                 Vwf 
                 1.867 
                 4.023 
                 3.723 
                 1.433 
                 4.000 
                 −2.133 
               
               
                 125500000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:135328001- 
                 Emp1 
                 3.189 
                 3.023 
                 4.893 
                 3.433 
                 4.322 
                 −1.133 
               
               
                 135329000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:30862001- 
                 4930412F09Rik 
                 2.867 
                 4.193 
                 4.308 
                 3.433 
                 4.170 
                 −1.303 
               
               
                 30863000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:40146001- 
                 Gm5567 
                 2.452 
                 4.193 
                 4.308 
                 2.433 
                 3.459 
                 −1.007 
               
               
                 40147000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:40319001- 
                 Agk 
                 2.867 
                 3.608 
                 3.308 
                 4.240 
                 4.087 
                 −1.220 
               
               
                 40320000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:71803001- 
                 Immt 
                 2.867 
                 3.831 
                 3.723 
                 4.017 
                 4.322 
                 −1.455 
               
               
                 71804000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:83523001- 
                 Stambp 
                 2.452 
                 3.608 
                 3.723 
                 4.240 
                 3.700 
                 −1.248 
               
               
                 83524000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:83684001- 
                 Vax2 
                 2.452 
                 3.608 
                 4.045 
                 4.433 
                 4.087 
                 −1.635 
               
               
                 83685000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:86344001- 
                 Pcyox1 
                 1.867 
                 3.608 
                 1.723 
                 3.754 
                 3.170 
                 −1.303 
               
               
                 86345000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:100063001- 
                 Prcp 
                 3.452 
                 4.023 
                 4.531 
                 4.433 
                 4.644 
                 −1.192 
               
               
                 100064000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:106624001- 
                 Rps3 
                 2.452 
                 3.831 
                 3.308 
                 4.240 
                 3.459 
                 −1.007 
               
               
                 106625000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:108023001- 
                 Arhgef17 
                 2.452 
                 3.023 
                 3.723 
                 3.433 
                 4.170 
                 −1.718 
               
               
                 108024000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:112892001- 
                 Taf10 
                 0.867 
                 2.608 
                 2.723 
                 1.433 
                 3.585 
                 −2.718 
               
               
                 112893000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:113577001- 
                 Gm4759 
                 1.867 
                 3.345 
                 3.308 
                 4.017 
                 3.459 
                 −1.592 
               
               
                 113578000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:117120001- 
                 Tmem41b 
                 1.867 
                 3.345 
                 4.308 
                 3.433 
                 3.585 
                 −1.718 
               
               
                 117121000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:125259001- 
                 Rps15a 
                 0.867 
                 2.023 
                 1.723 
                 2.433 
                 3.459 
                 −2.592 
               
               
                 125260000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:135022001- 
                 Zfp646 
                 2.867 
                 3.345 
                 4.723 
                 3.433 
                 3.907 
                 −1.040 
               
               
                 135023000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:147284001- 
                 1810014F10Rik 
                 2.452 
                 4.023 
                 3.308 
                 4.240 
                 3.459 
                 −1.007 
               
               
                 147285000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:148278001- 
                 Sigirr 
                 1.867 
                 3.831 
                 3.308 
                 3.017 
                 3.585 
                 −1.718 
               
               
                 148279000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:149085001- 
                 Tollip 
                 2.452 
                 3.608 
                 2.723 
                 4.017 
                 3.459 
                 −1.007 
               
               
                 149086000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:151029001- 
                 Dhcr7 
                 2.452 
                 3.831 
                 4.045 
                 3.017 
                 3.807 
                 −1.355 
               
               
                 151030000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:25302001- 
                 Zfp428 
                 1.867 
                 3.608 
                 3.308 
                 4.017 
                 4.170 
                 −2.303 
               
               
                 25303000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:25348001- 
                 Xrcc1 
                 2.452 
                 3.023 
                 4.308 
                 3.017 
                 3.459 
                 −1.007 
               
               
                 25349000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:28299001- 
                 Prx 
                 2.867 
                 3.345 
                 3.308 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 28300000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:31429001- 
                 Rbm42 
                 2.452 
                 2.023 
                 2.723 
                 4.433 
                 3.459 
                 −1.007 
               
               
                 31430000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:3601001- 
                 Cnot3 
                 1.867 
                 3.831 
                 4.045 
                 2.433 
                 3.585 
                 −1.718 
               
               
                 3602000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:4092001- 
                 Leng8 
                 2.452 
                 3.831 
                 4.308 
                 3.017 
                 3.700 
                 −1.248 
               
               
                 4093000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:51486001- 
                 1700028J19Rik 
                 3.189 
                 3.608 
                 4.893 
                 4.017 
                 4.248 
                 −1.059 
               
               
                 51487000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:51500001- 
                 2410002F23Rik 
                 2.452 
                 4.023 
                 3.308 
                 3.754 
                 3.907 
                 −1.455 
               
               
                 51501000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:52246001- 
                 Gm15545 
                 2.452 
                 3.608 
                 3.723 
                 3.754 
                 3.700 
                 −1.248 
               
               
                 52247000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:52320001- 
                 Nosip 
                 2.452 
                 3.608 
                 4.045 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 52321000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:52890001- 
                 Rasip1 
                 2.867 
                 3.608 
                 4.045 
                 3.754 
                 3.907 
                 −1.040 
               
               
                 52891000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:53198001- 
                 Ccdc114 
                 2.452 
                 3.023 
                 2.723 
                 4.017 
                 3.585 
                 −1.133 
               
               
                 53199000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:5364001- 
                 Vmn1r58 
                 2.867 
                 3.345 
                 4.045 
                 4.240 
                 4.087 
                 −1.220 
               
               
                 5365000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:63103001- 
                 Cyfip1 
                 2.452 
                 3.345 
                 2.723 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 63104000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:74884001- 
                 Synm 
                 1.867 
                 3.831 
                 3.308 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 74885000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:88302001- 
                 Slc28a1 
                 1.867 
                 4.023 
                 2.723 
                 3.017 
                 3.459 
                 −1.592 
               
               
                 88303000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:97767001- 
                 Dlg2 
                 3.452 
                 2.608 
                 4.531 
                 4.433 
                 4.585 
                 −1.133 
               
               
                 97768000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:99723001- 
                 Ccdc90b 
                 1.867 
                 2.608 
                 4.308 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 99724000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:99884001- 
                 4632427E13Rik 
                 1.867 
                 4.193 
                 4.045 
                 4.017 
                 3.807 
                 −1.940 
               
               
                 99885000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:107816001- 
                 Exoc3l 
                 2.452 
                 2.023 
                 2.723 
                 4.433 
                 3.907 
                 −1.455 
               
               
                 107817000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:107932001- 
                 Kctd19 
                 2.867 
                 4.345 
                 4.045 
                 4.017 
                 4.087 
                 −1.220 
               
               
                 107933000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:108111001- 
                 Gm8841 
                 2.867 
                 3.831 
                 4.045 
                 5.339 
                 3.907 
                 −1.040 
               
               
                 108112000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:109536001- 
                 Sntb2 
                 2.867 
                 3.608 
                 4.045 
                 3.754 
                 4.000 
                 −1.133 
               
               
                 109537000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:112200001- 
                 2400003C14Rik 
                 2.452 
                 3.831 
                 3.723 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 112201000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:121970001- 
                 Osgin1 
                 1.867 
                 2.608 
                 3.308 
                 2.433 
                 3.000 
                 −1.133 
               
               
                 121971000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:14902001- 
                 Cln8 
                 2.452 
                 3.831 
                 3.308 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 14903000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:26697001- 
                 Letm2 
                 2.452 
                 4.345 
                 3.723 
                 3.433 
                 4.087 
                 −1.635 
               
               
                 26698000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:28157001- 
                 Prosc 
                 2.452 
                 3.831 
                 2.723 
                 4.017 
                 3.585 
                 −1.133 
               
               
                 28158000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:4106001- 
                 Cd209f 
                 1.867 
                 2.608 
                 2.723 
                 4.602 
                 3.322 
                 −1.455 
               
               
                 4107000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:47102001- 
                 Lrp2bp 
                 3.189 
                 3.831 
                 4.045 
                 4.433 
                 4.585 
                 −1.396 
               
               
                 47103000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:4859001- 
                 Rpl21-ps14 
                 2.867 
                 3.608 
                 2.723 
                 5.017 
                 4.170 
                 −1.303 
               
               
                 4860000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:72236001- 
                 Zfp869 
                 0.867 
                 3.608 
                 1.723 
                 2.433 
                 2.807 
                 −1.940 
               
               
                 72237000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:72834001- 
                 Cope 
                 1.867 
                 4.193 
                 3.723 
                 4.602 
                 3.459 
                 −1.592 
               
               
                 72835000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:73056001- 
                 Fkbp8 
                 0.715 
                 4.023 
                 4.308 
                 3.754 
                 3.322 
                 −2.607 
               
               
                 73057000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:73900001- 
                 Ocel1 
                 1.867 
                 4.345 
                 2.723 
                 3.433 
                 3.170 
                 −1.303 
               
               
                 73901000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:74708001- 
                 Rab8a 
                 2.452 
                 3.831 
                 4.045 
                 3.017 
                 4.000 
                 −1.548 
               
               
                 74709000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:83341001- 
                 Gab1 
                 1.867 
                 2.608 
                 2.723 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 83342000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:86591001- 
                 C330011M18Rik 
                 1.867 
                 2.608 
                 3.308 
                 4.433 
                 3.459 
                 −1.592 
               
               
                 86592000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:87414001- 
                 Gcdh 
                 2.452 
                 3.345 
                 4.308 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 87415000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:87613001- 
                 Man2b1 
                 0.867 
                 2.608 
                 1.571 
                 4.017 
                 3.700 
                 −2.833 
               
               
                 87614000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:97507001- 
                 Gpr56 
                 1.867 
                 2.023 
                 3.723 
                 1.433 
                 3.322 
                 −1.455 
               
               
                 97508000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:102494001- 
                 Cep63 
                 2.867 
                 4.193 
                 3.308 
                 4.433 
                 4.248 
                 −1.381 
               
               
                 102495000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:103371001- 
                 Bfsp2 
                 2.452 
                 4.023 
                 3.308 
                 3.754 
                 4.170 
                 −1.718 
               
               
                 103372000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:107229001- 
                 Hemk1 
                 2.452 
                 3.608 
                 4.531 
                 2.433 
                 3.585 
                 −1.133 
               
               
                 107230000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:107436001- 
                 Tmem115 
                 2.452 
                 3.345 
                 1.723 
                 4.240 
                 3.459 
                 −1.007 
               
               
                 107437000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:20294001- 
                 Gm17523 
                 1.867 
                 4.345 
                 2.723 
                 3.017 
                 3.807 
                 −1.940 
               
               
                 20295000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:21312001- 
                 Dnm2 
                 2.452 
                 1.023 
                 4.045 
                 3.017 
                 3.907 
                 −1.455 
               
               
                 21313000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:44755001- 
                 Ube4a 
                 2.452 
                 4.023 
                 4.045 
                 3.433 
                 3.907 
                 −1.455 
               
               
                 44756000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:50447001- 
                 Dlat 
                 2.452 
                 4.023 
                 3.308 
                 4.017 
                 3.585 
                 −1.133 
               
               
                 50448000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:51674001- 
                 9230115E21Rik 
                 1.867 
                 3.023 
                 3.723 
                 4.017 
                 3.907 
                 −2.040 
               
               
                 51675000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:51808001- 
                 Gm6981 
                 2.452 
                 2.023 
                 4.045 
                 4.240 
                 4.000 
                 −1.548 
               
               
                 51809000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:54478001- 
                 Acsbg1 
                 0.867 
                 2.608 
                 2.723 
                 4.602 
                 3.585 
                 −2.718 
               
               
                 54479000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:57444001- 
                 Ulk3 
                 2.452 
                 3.831 
                 3.308 
                 4.017 
                 3.807 
                 −1.355 
               
               
                 57445000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:64030001- 
                 Snapc5 
                 1.867 
                 4.023 
                 3.723 
                 4.017 
                 3.000 
                 −1.133 
               
               
                 64031000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:78223001- 
                 Ooep 
                 1.867 
                 3.023 
                 3.308 
                 4.602 
                 3.459 
                 −1.592 
               
               
                 78224000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:96334001- 
                 BC043934 
                 2.452 
                 2.023 
                 4.308 
                 3.433 
                 3.807 
                 −1.355 
               
               
                 96335000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:97082001- 
                 Rpl7a-ps10 
                 1.867 
                 3.345 
                 3.308 
                 3.433 
                 3.807 
                 −1.940 
               
               
                 97083000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:98469001- 
                 Copb2 
                 2.452 
                 3.831 
                 3.723 
                 3.433 
                 3.907 
                 −1.455 
               
               
                 98470000 
                   
                   
                   
                   
                   
                   
                   
               
            
           
           
               
            
               
                 Gene body and promoter cleavage 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Chr1:13682001- 
                 Xkr9 
                 1.867 
                 4.930 
                 3.723 
                 3.433 
                 4.392 
                 −2.525 
               
               
                 13683000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:136869001- 
                 Ube2t 
                 2.452 
                 3.608 
                 4.308 
                 2.433 
                 3.585 
                 −1.133 
               
               
                 136870000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:146094001- 
                 Rgs1 
                 1.867 
                 3.831 
                 4.045 
                 3.754 
                 4.000 
                 −2.133 
               
               
                 146095000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:157123001- 
                 Xpr1 
                 3.452 
                 3.831 
                 4.045 
                 4.754 
                 4.644 
                 −1.192 
               
               
                 157124000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:173214001- 
                 Usp21 
                 2.452 
                 3.023 
                 4.308 
                 2.433 
                 4.392 
                 −1.940 
               
               
                 173215000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:173436001- 
                 Refbp2 
                 1.867 
                 3.345 
                 3.308 
                 4.433 
                 4.000 
                 −2.133 
               
               
                 173437000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:173826001- 
                 Gm10521 
                 1.867 
                 3.831 
                 1.723 
                 3.433 
                 4.000 
                 −2.133 
               
               
                 173827000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:174020001- 
                 Copa 
                 1.867 
                 3.831 
                 3.723 
                 1.433 
                 3.700 
                 −1.833 
               
               
                 174021000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:175530001- 
                 Pydc4 
                 2.452 
                 3.608 
                 4.308 
                 2.433 
                 3.585 
                 −1.133 
               
               
                 175531000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:180188001- 
                 Gm9982 
                 1.867 
                 3.608 
                 3.308 
                 3.754 
                 4.087 
                 −2.220 
               
               
                 180189000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:188796001- 
                 D1Pas1 
                 2.452 
                 4.023 
                 3.723 
                 3.433 
                 3.700 
                 −1.248 
               
               
                 188797000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:190163001- 
                 Ush2a 
                 3.867 
                 4.023 
                 5.045 
                 4.754 
                 5.170 
                 −1.303 
               
               
                 190164000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:36669001- 
                 Fam178b 
                 2.452 
                 3.023 
                 3.308 
                 3.754 
                 4.087 
                 −1.635 
               
               
                 36670000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:39422001- 
                 Rpl31 
                 2.452 
                 3.831 
                 4.045 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 39423000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:4774001- 
                 Mrpl15 
                 1.867 
                 2.608 
                 3.308 
                 2.433 
                 3.170 
                 −1.303 
               
               
                 4775000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:55232001- 
                 Rftn2 
                 2.452 
                 3.608 
                 4.045 
                 3.017 
                 3.700 
                 −1.248 
               
               
                 55233000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:58744001- 
                 Als2cr12 
                 3.189 
                 4.483 
                 4.308 
                 4.240 
                 4.322 
                 −1.133 
               
               
                 58745000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:60784001- 
                 Cd28 
                 4.037 
                 4.483 
                 5.424 
                 4.754 
                 5.129 
                 −1.092 
               
               
                 60785000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:60951001- 
                 Ctla4 
                 1.867 
                 3.608 
                 1.723 
                 3.433 
                 3.807 
                 −1.940 
               
               
                 60952000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:64660001- 
                 Mettl21a 
                 1.867 
                 3.831 
                 4.045 
                 3.017 
                 4.000 
                 −2.133 
               
               
                 64661000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:80380001- 
                 Gm6189 
                 2.452 
                 3.023 
                 4.308 
                 3.017 
                 3.459 
                 −1.007 
               
               
                 80381000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:105628001- 
                 Gm7263 
                 3.452 
                 4.023 
                 4.893 
                 4.754 
                 4.644 
                 −1.192 
               
               
                 105629000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:128145001- 
                 Pmel 
                 2.867 
                 3.345 
                 4.045 
                 3.754 
                 4.248 
                 −1.381 
               
               
                 128146000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:29043001- 
                 Echdc1 
                 3.452 
                 3.608 
                 4.531 
                 4.433 
                 4.755 
                 −1.303 
               
               
                 29044000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:79634001- 
                 Cirbp 
                 2.867 
                 3.023 
                 3.308 
                 4.433 
                 3.907 
                 −1.040 
               
               
                 79635000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:80070001- 
                 Adat3 
                 0.867 
                 3.608 
                 2.723 
                 3.433 
                 3.000 
                 −2.133 
               
               
                 80071000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:80394001- 
                 Gadd45b 
                 0.867 
                 3.608 
                 1.723 
                 2.433 
                 2.322 
                 −1.455 
               
               
                 80395000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:80437001- 
                 Gng7 
                 1.867 
                 3.608 
                 2.723 
                 3.017 
                 3.700 
                 −1.833 
               
               
                 80438000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:80738001- 
                 Tjp3 
                 1.867 
                 4.023 
                 2.723 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 80739000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:86211001- 
                 BC030307 
                 2.867 
                 3.831 
                 1.723 
                 4.602 
                 4.248 
                 −1.381 
               
               
                 86212000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:98910001- 
                 Gad1-ps 
                 1.867 
                 3.023 
                 4.893 
                 3.754 
                 4.459 
                 −2.592 
               
               
                 98911000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:106618001- 
                 Gm885 
                 0.867 
                 3.831 
                 2.723 
                 3.017 
                 3.700 
                 −2.833 
               
               
                 106619000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:115130001- 
                 Fdxr 
                 2.452 
                 3.608 
                 3.723 
                 3.433 
                 3.585 
                 −1.133 
               
               
                 115131000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:115720001- 
                 Myo15b 
                 1.867 
                 3.608 
                 3.308 
                 2.433 
                 3.000 
                 −1.133 
               
               
                 115721000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:116534001- 
                 1810032O08Rik 
                 2.867 
                 3.608 
                 4.045 
                 4.433 
                 3.907 
                 −1.040 
               
               
                 116535000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:118345001- 
                 Engase 
                 1.867 
                 4.023 
                 3.308 
                 3.754 
                 4.170 
                 −2.303 
               
               
                 118346000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:119141001- 
                 Gaa 
                 2.452 
                 3.831 
                 2.723 
                 4.017 
                 3.807 
                 −1.355 
               
               
                 119142000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:120302001- 
                 Tspan10 
                 2.452 
                 4.345 
                 1.571 
                 4.433 
                 4.000 
                 −1.548 
               
               
                 120303000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:120510001- 
                 Gm11768 
                 1.867 
                 3.608 
                 3.723 
                 3.754 
                 3.000 
                 −1.133 
               
               
                 120511000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:46057001- 
                 Cyfip2 
                 2.867 
                 4.193 
                 3.308 
                 4.240 
                 4.392 
                 −1.525 
               
               
                 46058000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:5705001- 
                 Pgam2 
                 2.867 
                 3.023 
                 3.308 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 5706000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:57987001- 
                 Mrpl22 
                 0.867 
                 4.483 
                 4.045 
                 4.240 
                 3.000 
                 −2.133 
               
               
                 57988000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:6017001- 
                 Nudcd3 
                 1.867 
                 4.023 
                 1.723 
                 3.433 
                 4.000 
                 −2.133 
               
               
                 6018000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:60394001- 
                 Gm17423 
                 1.867 
                 2.608 
                 2.723 
                 3.017 
                 3.322 
                 −1.455 
               
               
                 60395000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:60751001- 
                 Map2k3 
                 2.452 
                 3.345 
                 4.308 
                 4.017 
                 4.322 
                 −1.870 
               
               
                 60752000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:6427001- 
                 Gm11974 
                 2.867 
                 4.023 
                 3.308 
                 4.602 
                 4.087 
                 −1.220 
               
               
                 6428000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:6535001- 
                 Wap 
                 0.715 
                 3.608 
                 3.308 
                 4.433 
                 4.170 
                 −3.455 
               
               
                 6536000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:69712001- 
                 2810408A11Rik 
                 2.452 
                 2.023 
                 5.045 
                 4.433 
                 4.000 
                 −1.548 
               
               
                 69713000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:73021001- 
                 Shpk 
                 1.867 
                 4.023 
                 3.723 
                 1.433 
                 3.000 
                 −1.133 
               
               
                 73022000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:75285001- 
                 Tlcd2 
                 1.867 
                 4.023 
                 3.308 
                 4.433 
                 4.170 
                 −2.303 
               
               
                 75286000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:80021001- 
                 Rhot1 
                 3.452 
                 3.345 
                 4.893 
                 4.017 
                 4.459 
                 −1.007 
               
               
                 80022000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:96636001- 
                 Snx11 
                 1.867 
                 4.483 
                 3.723 
                 3.433 
                 4.087 
                 −2.220 
               
               
                 96637000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:96910001- 
                 Mrpl10 
                 2.452 
                 3.608 
                 3.723 
                 3.433 
                 3.700 
                 −1.248 
               
               
                 96911000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:98634001- 
                 Nr1d1 
                 2.452 
                 3.831 
                 2.723 
                 4.433 
                 3.459 
                 −1.007 
               
               
                 98635000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:102142001- 
                 Gpr68 
                 2.867 
                 3.345 
                 2.723 
                 4.754 
                 3.907 
                 −1.040 
               
               
                 102143000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:102387001- 
                 Kif4-ps 
                 2.452 
                 3.831 
                 1.723 
                 4.433 
                 3.459 
                 −1.007 
               
               
                 102388000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:114001001- 
                 Pld4 
                 1.867 
                 3.023 
                 2.723 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 114002000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:4236001- 
                 2410017P09Rik 
                 0.867 
                 2.023 
                 3.308 
                 4.240 
                 3.459 
                 −2.592 
               
               
                 4237000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:70398001- 
                 Klhdc2 
                 2.452 
                 1.023 
                 3.308 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 70399000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:86564001- 
                 Eif2b2 
                 1.867 
                 3.345 
                 3.308 
                 3.754 
                 3.459 
                 −1.592 
               
               
                 86565000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:101717001- 
                 Gm10257 
                 3.452 
                 3.023 
                 5.531 
                 3.754 
                 4.954 
                 −1.502 
               
               
                 101718000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:21577001- 
                 Zkscan4 
                 2.452 
                 3.023 
                 3.723 
                 3.433 
                 3.459 
                 −1.007 
               
               
                 21578000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:21594001- 
                 Gm11273 
                 2.452 
                 3.608 
                 3.308 
                 4.017 
                 3.585 
                 −1.133 
               
               
                 21595000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:23629001- 
                 Hist1h3g 
                 2.867 
                 1.023 
                 3.723 
                 4.433 
                 3.907 
                 −1.040 
               
               
                 23630000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:23637001- 
                 Hist1h3f 
                 2.452 
                 3.608 
                 4.723 
                 1.433 
                 3.459 
                 −1.007 
               
               
                 23638000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:23701001- 
                 Hist1h2be 
                 2.452 
                 3.608 
                 4.308 
                 3.017 
                 3.907 
                 −1.455 
               
               
                 23702000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:33107001- 
                 Serpinb9 
                 2.452 
                 3.608 
                 3.723 
                 4.892 
                 3.807 
                 −1.355 
               
               
                 33108000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:40980001- 
                 Gcnt2 
                 1.867 
                 3.608 
                 2.723 
                 3.017 
                 4.000 
                 −2.133 
               
               
                 40981000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:43463001- 
                 Sirt5 
                 2.452 
                 4.345 
                 4.045 
                 3.017 
                 3.459 
                 −1.007 
               
               
                 43464000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:58439001- 
                 Kif27 
                 2.452 
                 3.345 
                 4.045 
                 3.017 
                 3.459 
                 −1.007 
               
               
                 58440000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:62818001- 
                 Gm5665 
                 2.867 
                 4.483 
                 4.308 
                 4.433 
                 4.170 
                 −1.303 
               
               
                 62819000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:73470001- 
                 Mrpl36 
                 1.867 
                 3.345 
                 2.723 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 73471000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:76125001- 
                 Spata9 
                 2.452 
                 3.023 
                 3.723 
                 3.433 
                 3.700 
                 −1.248 
               
               
                 76126000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:76210001- 
                 Arsk 
                 2.867 
                 2.608 
                 4.723 
                 3.017 
                 4.459 
                 −1.592 
               
               
                 76211000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:118518001- 
                 Tgds 
                 1.867 
                 4.345 
                 2.723 
                 4.754 
                 3.322 
                 −1.455 
               
               
                 118519000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:26528001- 
                 1700054O19Rik 
                 1.867 
                 4.483 
                 4.045 
                 3.754 
                 3.907 
                 −2.040 
               
               
                 26529000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:55505001- 
                 Bcl2l2 
                 1.867 
                 3.023 
                 4.308 
                 1.433 
                 3.585 
                 −1.718 
               
               
                 55506000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:55721001- 
                 Ap1g2 
                 2.452 
                 4.193 
                 4.308 
                 4.017 
                 3.585 
                 −1.133 
               
               
                 55722000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:59897001- 
                 Phf11 
                 0.867 
                 2.608 
                 1.723 
                 4.602 
                 2.585 
                 −1.718 
               
               
                 59898000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:8162001- 
                 Gm5797 
                 1.867 
                 3.831 
                 3.308 
                 3.433 
                 4.459 
                 −2.592 
               
               
                 8163000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:100241001- 
                 Slc11a2 
                 2.867 
                 4.345 
                 3.723 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 100242000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:102114001- 
                 Mfsd5 
                 2.452 
                 4.930 
                 4.045 
                 3.017 
                 3.807 
                 −1.355 
               
               
                 102115000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:38227001- 
                 Klf10 
                 3.189 
                 3.831 
                 3.723 
                 4.602 
                 2.322 
                 0.867 
               
               
                 38228000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:39584001- 
                 Tm7sf4 
                 3.252 
                 3.608 
                 4.045 
                 4.754 
                 3.720 
                 −0.468 
               
               
                 39585000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:58819001- 
                 Mtss1 
                 2.452 
                 3.345 
                 3.308 
                 3.754 
                 3.585 
                 −1.133 
               
               
                 58820000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:61821001- 
                 Myc 
                 2.452 
                 4.023 
                 4.045 
                 4.754 
                 3.459 
                 −1.007 
               
               
                 61822000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:66430001- 
                 Phf20l1 
                 2.867 
                 4.345 
                 4.723 
                 4.433 
                 4.087 
                 −1.220 
               
               
                 66431000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:76505001- 
                 Ppp1r16a 
                 2.867 
                 3.608 
                 3.723 
                 4.433 
                 4.170 
                 −1.303 
               
               
                 76506000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:76883001- 
                 Apol6 
                 0.867 
                 4.345 
                 2.723 
                 3.433 
                 3.807 
                 −2.940 
               
               
                 76884000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:78243001- 
                 Mpst 
                 2.867 
                 4.608 
                 3.723 
                 4.017 
                 4.170 
                 −1.303 
               
               
                 78244000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:78984001- 
                 Sox10 
                 1.867 
                 3.345 
                 1.723 
                 3.754 
                 3.000 
                 −1.133 
               
               
                 78985000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:79977001- 
                 Tab1 
                 3.452 
                 3.831 
                 4.531 
                 5.017 
                 4.459 
                 −1.007 
               
               
                 79978000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:82842001- 
                 Nfam1 
                 2.452 
                 3.831 
                 4.045 
                 3.017 
                 3.700 
                 −1.248 
               
               
                 82843000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:89316001- 
                 C230037L18Rik 
                 1.867 
                 3.608 
                 3.308 
                 4.017 
                 4.322 
                 −2.455 
               
               
                 89317000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:95908001- 
                 D030018L15Rik 
                 2.867 
                 4.023 
                 2.723 
                 4.433 
                 4.087 
                 −1.220 
               
               
                 95909000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:98548001- 
                 Ccdc65 
                 2.867 
                 3.023 
                 4.308 
                 3.754 
                 4.392 
                 −1.525 
               
               
                 98549000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:11071001- 
                 Snn 
                 2.452 
                 3.608 
                 4.308 
                 3.017 
                 4.000 
                 −1.548 
               
               
                 11072000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:11314001- 
                 Tnfrsf17 
                 3.189 
                 3.831 
                 4.308 
                 4.240 
                 4.322 
                 −1.133 
               
               
                 11315000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:17117001- 
                 2610318N02Rik 
                 2.867 
                 4.193 
                 4.308 
                 3.754 
                 4.087 
                 −1.220 
               
               
                 17118000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:18815001- 
                 Ufd1l 
                 1.867 
                 3.023 
                 3.723 
                 1.433 
                 3.322 
                 −1.455 
               
               
                 18816000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:29585001- 
                 Opa1 
                 1.867 
                 4.023 
                 1.723 
                 3.433 
                 3.459 
                 −1.592 
               
               
                 29586000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:30524001- 
                 Tmem44 
                 2.452 
                 4.483 
                 4.045 
                 3.433 
                 3.700 
                 −1.248 
               
               
                 30525000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:32428001- 
                 Tctex1d2 
                 2.452 
                 5.023 
                 3.723 
                 3.433 
                 3.907 
                 −1.455 
               
               
                 32429000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:38435001- 
                 Pla1a 
                 2.867 
                 3.345 
                 1.723 
                 4.892 
                 4.000 
                 −1.133 
               
               
                 38436000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:4882001- 
                 Fam100a 
                 2.452 
                 3.023 
                 2.723 
                 5.017 
                 3.907 
                 −1.455 
               
               
                 4883000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:49788001- 
                 Gm15518 
                 2.452 
                 3.831 
                 2.723 
                 4.017 
                 4.322 
                 −1.870 
               
               
                 49789000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:50593001- 
                 Ccdc54 
                 1.867 
                 4.345 
                 1.571 
                 4.602 
                 3.907 
                 −2.040 
               
               
                 50594000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:52249001- 
                 Alcam 
                 1.867 
                 3.831 
                 1.571 
                 3.754 
                 3.170 
                 −1.303 
               
               
                 52250000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:57064001- 
                 2310005G13Rik 
                 2.452 
                 3.831 
                 4.045 
                 3.017 
                 3.459 
                 −1.007 
               
               
                 57065000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:57194001- 
                 Tbc1d23 
                 1.867 
                 3.608 
                 1.723 
                 3.433 
                 3.170 
                 −1.303 
               
               
                 57195000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:87438001- 
                 Rwdd2b 
                 1.867 
                 3.608 
                 3.723 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 87439000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:92393001- 
                 Rcan1 
                 3.452 
                 3.608 
                 4.045 
                 4.754 
                 2.585 
                 0.867 
               
               
                 92394000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:93599001- 
                 Setd4 
                 0.867 
                 3.608 
                 2.723 
                 2.433 
                 3.459 
                 −2.592 
               
               
                 93600000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:23772001- 
                 Mmp25 
                 2.867 
                 2.608 
                 3.723 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 23773000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:26107001- 
                 Solh 
                 2.452 
                 3.608 
                 4.308 
                 3.017 
                 3.459 
                 −1.007 
               
               
                 26108000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:33238001- 
                 Zfp563 
                 1.867 
                 3.345 
                 2.723 
                 3.754 
                 3.000 
                 −1.133 
               
               
                 33239000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:34201001- 
                 Col11a2 
                 1.867 
                 2.608 
                 3.308 
                 3.017 
                 3.807 
                 −1.940 
               
               
                 34202000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:34699001- 
                 Notch4 
                 1.867 
                 3.608 
                 4.045 
                 2.433 
                 3.907 
                 −2.040 
               
               
                 34700000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:35094001- 
                 Hspa1b 
                 2.452 
                 3.608 
                 4.531 
                 3.017 
                 3.459 
                 −1.007 
               
               
                 35095000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:35887001- 
                 Gm20442 
                 2.867 
                 3.345 
                 3.308 
                 4.240 
                 4.087 
                 −1.220 
               
               
                 35888000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:45645001- 
                 Aars2 
                 2.452 
                 4.831 
                 4.045 
                 4.240 
                 4.000 
                 −1.548 
               
               
                 45646000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:6652001- 
                 Dynlt1c 
                 2.452 
                 4.345 
                 2.723 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 6653000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:33952001- 
                 2410004N09Rik 
                 0.867 
                 3.023 
                 3.308 
                 3.433 
                 3.322 
                 −2.455 
               
               
                 33953000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:35865001- 
                 1700066B19Rik 
                 2.452 
                 4.193 
                 4.723 
                 4.433 
                 4.322 
                 −1.870 
               
               
                 35866000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:37204001- 
                 Pcdha11 
                 3.867 
                 3.345 
                 3.308 
                 5.520 
                 4.907 
                 −1.040 
               
               
                 37205000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:38497001- 
                 Gnpda1 
                 2.452 
                 2.608 
                 3.308 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 38498000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:4377001- 
                 Gm17417 
                 2.867 
                 2.608 
                 3.308 
                 4.433 
                 4.170 
                 −1.303 
               
               
                 4378000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:61100001- 
                 Camk2a 
                 2.452 
                 3.023 
                 4.045 
                 3.017 
                 3.907 
                 −1.455 
               
               
                 61101000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:63854001- 
                 Txnl1 
                 2.867 
                 4.023 
                 4.531 
                 3.017 
                 3.907 
                 −1.040 
               
               
                 63855000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:24753001- 
                 E030010A14Rik 
                 2.867 
                 3.023 
                 4.308 
                 4.017 
                 4.170 
                 −1.303 
               
               
                 24754000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:24951001- 
                 Gm10053 
                 0.867 
                 4.193 
                 2.723 
                 4.017 
                 2.322 
                 −1.455 
               
               
                 24952000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:28835001- 
                 Gm6788 
                 2.452 
                 3.345 
                 2.723 
                 4.433 
                 3.807 
                 −1.355 
               
               
                 28836000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:28958001- 
                 Slc1a1 
                 2.867 
                 3.345 
                 4.308 
                 3.433 
                 3.907 
                 −1.040 
               
               
                 28959000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:29884001- 
                 Ranbp6 
                 2.452 
                 4.483 
                 1.723 
                 5.133 
                 4.087 
                 −1.635 
               
               
                 29885000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:4011001- 
                 Ndufv1 
                 2.452 
                 3.345 
                 4.045 
                 3.433 
                 4.087 
                 −1.635 
               
               
                 4012000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:42201001- 
                 Avpi1 
                 2.452 
                 2.023 
                 4.723 
                 3.754 
                 3.907 
                 −1.455 
               
               
                 42202000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:4314001- 
                 Kdm2a 
                 2.867 
                 4.345 
                 4.045 
                 3.754 
                 4.000 
                 −1.133 
               
               
                 4315000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:43900001- 
                 Abcc2 
                 2.452 
                 4.193 
                 1.723 
                 4.240 
                 3.459 
                 −1.007 
               
               
                 43901000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:44029001- 
                 Cpn1 
                 2.452 
                 2.023 
                 4.045 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 44030000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:47916001- 
                 Wdr96 
                 3.452 
                 3.831 
                 3.723 
                 4.892 
                 4.524 
                 −1.072 
               
               
                 47917000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:48010001- 
                 Ccdc147 
                 1.867 
                 3.023 
                 2.723 
                 3.017 
                 3.000 
                 −1.133 
               
               
                 48011000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:4840001- 
                 Ccdc87 
                 2.452 
                 3.023 
                 4.045 
                 3.017 
                 3.907 
                 −1.455 
               
               
                 4841000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:4965001- 
                 Mrpl11 
                 1.867 
                 4.345 
                 3.723 
                 4.017 
                 4.000 
                 −2.133 
               
               
                 4966000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:5091001- 
                 Yif1a 
                 1.867 
                 3.831 
                 4.308 
                 3.433 
                 3.585 
                 −1.718 
               
               
                 5092000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:60929001- 
                 Sfxn4 
                 2.452 
                 3.831 
                 3.308 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 60930000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:7012001- 
                 Gpr137 
                 1.867 
                 2.608 
                 3.723 
                 3.017 
                 3.807 
                 −1.940 
               
               
                 7013000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:7026001- 
                 Bad 
                 1.867 
                 3.345 
                 3.308 
                 3.017 
                 3.585 
                 −1.718 
               
               
                 7027000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:9053001- 
                 Eef1g 
                 1.867 
                 3.345 
                 1.723 
                 3.433 
                 3.907 
                 −2.040 
               
               
                 9054000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:112094001- 
                 BC125332 
                 1.867 
                 4.345 
                 4.045 
                 3.433 
                 3.170 
                 −1.303 
               
               
                 112095000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:120141001- 
                 Vps39 
                 2.452 
                 4.193 
                 3.723 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 120142000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:128414001- 
                 Gm355 
                 2.452 
                 3.608 
                 3.308 
                 4.433 
                 3.700 
                 −1.248 
               
               
                 128415000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:129007001- 
                 Gm14029 
                 2.452 
                 3.831 
                 4.531 
                 4.433 
                 3.700 
                 −1.248 
               
               
                 129008000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:130998001- 
                 Spef1 
                 2.452 
                 3.023 
                 3.308 
                 4.602 
                 3.585 
                 −1.133 
               
               
                 130999000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:131747001- 
                 Prnp 
                 2.867 
                 3.345 
                 3.308 
                 4.433 
                 4.248 
                 −1.381 
               
               
                 131748000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:153443001- 
                 Commd7 
                 2.867 
                 3.831 
                 4.308 
                 3.754 
                 4.000 
                 −1.133 
               
               
                 153444000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:157296001- 
                 Src 
                 2.867 
                 3.345 
                 3.723 
                 4.017 
                 3.459 
                 −0.592 
               
               
                 157297000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:180192001- 
                 Slco4a1 
                 1.867 
                 2.608 
                 3.723 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 180193000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:181240001- 
                 Tpd52l2 
                 2.452 
                 3.608 
                 3.308 
                 4.240 
                 3.585 
                 −1.133 
               
               
                 181241000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:181453001- 
                 Oprl1 
                 2.452 
                 3.345 
                 3.723 
                 4.754 
                 3.585 
                 −1.133 
               
               
                 181454000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:25489001- 
                 Gm13520 
                 2.452 
                 3.608 
                 4.308 
                 3.433 
                 3.700 
                 −1.248 
               
               
                 25490000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:25998001- 
                 C330006A16Rik 
                 1.867 
                 3.831 
                 3.308 
                 3.433 
                 4.087 
                 −2.220 
               
               
                 25999000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:26743001- 
                 Surf6 
                 2.867 
                 4.023 
                 4.308 
                 3.433 
                 4.248 
                 −1.381 
               
               
                 26744000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:26879001- 
                 Slc2a6 
                 2.452 
                 2.023 
                 2.723 
                 4.017 
                 3.907 
                 −1.455 
               
               
                 26880000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:29946001- 
                 Pkn3 
                 1.867 
                 4.608 
                 3.308 
                 3.017 
                 3.459 
                 −1.592 
               
               
                 29947000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:30572001- 
                 Gm14488 
                 0.867 
                 2.608 
                 1.571 
                 3.754 
                 2.807 
                 −1.940 
               
               
                 30573000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:32432001- 
                 Pip5kl1 
                 2.867 
                 3.831 
                 3.723 
                 4.240 
                 4.000 
                 −1.133 
               
               
                 32433000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:32482001- 
                 Ak1 
                 1.867 
                 2.608 
                 4.045 
                 2.433 
                 3.322 
                 −1.455 
               
               
                 32483000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:34717001- 
                 Psmd5 
                 2.452 
                 3.608 
                 3.723 
                 3.433 
                 4.907 
                 −2.455 
               
               
                 34718000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:38851001- 
                 Gm13496 
                 2.452 
                 4.345 
                 2.723 
                 5.017 
                 3.807 
                 −1.355 
               
               
                 38852000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:75773001- 
                 Ttc30b 
                 2.452 
                 3.345 
                 3.308 
                 4.433 
                 4.000 
                 −1.548 
               
               
                 75774000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:76798001- 
                 Ttn 
                 3.452 
                 4.023 
                 4.723 
                 4.240 
                 4.858 
                 −1.406 
               
               
                 76799000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:93818001- 
                 4921507L20Rik 
                 1.867 
                 4.023 
                 4.308 
                 3.754 
                 4.087 
                 −2.220 
               
               
                 93819000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:123274001- 
                 Ndst3 
                 2.867 
                 3.608 
                 3.308 
                 4.240 
                 4.087 
                 −1.220 
               
               
                 123275000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:142260001- 
                 Gbp1 
                 0.867 
                 3.023 
                 4.045 
                 1.433 
                 3.170 
                 −2.303 
               
               
                 142261000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:14865001- 
                 Car3 
                 0.867 
                 2.023 
                 4.531 
                 2.433 
                 3.170 
                 −2.303 
               
               
                 14866000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:32806001- 
                 Usp13 
                 1.867 
                 2.608 
                 2.723 
                 3.017 
                 3.000 
                 −1.133 
               
               
                 32807000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:33972001- 
                 Dnajc19 
                 0.867 
                 3.608 
                 1.571 
                 3.754 
                 2.585 
                 −1.718 
               
               
                 33973000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:116793001- 
                 Btbd19 
                 1.867 
                 4.023 
                 3.308 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 116794000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:124360001- 
                 Utp11l 
                 2.452 
                 4.023 
                 4.531 
                 4.017 
                 4.087 
                 −1.635 
               
               
                 124361000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:124380001- 
                 Fhl3 
                 1.867 
                 4.023 
                 4.308 
                 1.433 
                 3.459 
                 −1.592 
               
               
                 124381000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:126805001- 
                 Gm12942 
                 1.867 
                 3.831 
                 2.723 
                 4.433 
                 3.000 
                 −1.133 
               
               
                 126806000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:128790001- 
                 Hpca 
                 1.867 
                 3.831 
                 3.308 
                 2.433 
                 3.170 
                 −1.303 
               
               
                 128791000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:129027001- 
                 Zbtb8os 
                 2.867 
                 3.831 
                 2.723 
                 4.433 
                 3.907 
                 −1.040 
               
               
                 129028000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:132301001- 
                 Smpdl3b 
                 1.867 
                 3.608 
                 3.308 
                 2.433 
                 3.700 
                 −1.833 
               
               
                 132302000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:135906001- 
                 9130020K20Rik 
                 2.452 
                 3.831 
                 4.045 
                 3.433 
                 4.170 
                 −1.718 
               
               
                 135907000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:135912001- 
                 Gm17388 
                 2.867 
                 2.608 
                 4.531 
                 3.017 
                 4.087 
                 −1.220 
               
               
                 135913000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:138730001- 
                 Gm16287 
                 2.452 
                 3.608 
                 3.723 
                 3.754 
                 4.000 
                 −1.548 
               
               
                 138731000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:140512001- 
                 Gm13031 
                 2.452 
                 2.608 
                 4.045 
                 4.433 
                 3.700 
                 −1.248 
               
               
                 140513000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:141180001- 
                 Slc25a34 
                 2.452 
                 3.831 
                 3.308 
                 4.017 
                 3.459 
                 −1.007 
               
               
                 141181000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:141572001- 
                 4930455G09Rik 
                 1.867 
                 4.345 
                 3.308 
                 4.892 
                 3.807 
                 −1.940 
               
               
                 141573000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:143484001- 
                 Pramef6 
                 1.867 
                 2.608 
                 3.308 
                 2.433 
                 3.585 
                 −1.718 
               
               
                 143485000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:143657001- 
                 Pramel4 
                 1.867 
                 5.111 
                 3.723 
                 4.017 
                 3.170 
                 −1.303 
               
               
                 143658000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:148533001- 
                 Pgd 
                 1.867 
                 3.023 
                 3.308 
                 3.017 
                 4.248 
                 −2.381 
               
               
                 148534000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:148856001- 
                 Nmnat1 
                 2.867 
                 3.831 
                 4.531 
                 3.433 
                 3.907 
                 −1.040 
               
               
                 148857000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:149561001- 
                 Car6 
                 0.867 
                 1.023 
                 3.308 
                 1.280 
                 4.087 
                 −3.220 
               
               
                 149562000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:151493001- 
                 Tnfrsf25 
                 2.452 
                 3.345 
                 4.045 
                 3.754 
                 4.000 
                 −1.548 
               
               
                 151494000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:151787001- 
                 Kcnab2 
                 2.867 
                 4.023 
                 3.723 
                 4.017 
                 4.087 
                 −1.220 
               
               
                 151788000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:154271001- 
                 2810405K02Rik 
                 2.452 
                 3.831 
                 3.308 
                 4.602 
                 3.459 
                 −1.007 
               
               
                 154272000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:43459001- 
                 Tesk1 
                 2.452 
                 4.023 
                 3.308 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 43460000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:43531001- 
                 Tpm2 
                 1.867 
                 2.608 
                 3.308 
                 3.754 
                 3.459 
                 −1.592 
               
               
                 43532000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:43542001- 
                 Tln1 
                 2.867 
                 3.608 
                 3.308 
                 4.240 
                 4.170 
                 −1.303 
               
               
                 43543000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:46393001- 
                 5830415F09Rik 
                 1.867 
                 4.193 
                 2.723 
                 4.240 
                 3.700 
                 −1.833 
               
               
                 46394000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:48079001- 
                 Nr4a3 
                 1.867 
                 4.023 
                 2.723 
                 3.017 
                 3.585 
                 −1.718 
               
               
                 48080000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:56757001- 
                 Actl7a 
                 1.867 
                 4.483 
                 3.723 
                 3.754 
                 3.807 
                 −1.940 
               
               
                 56758000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:89894001- 
                 Zfp352 
                 3.189 
                 2.608 
                 4.723 
                 4.240 
                 4.248 
                 −1.059 
               
               
                 89895000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:97589001- 
                 Nfia 
                 2.867 
                 4.483 
                 4.531 
                 3.017 
                 4.000 
                 −1.133 
               
               
                 97590000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:104040001- 
                 Slc10a6 
                 2.452 
                 4.345 
                 4.893 
                 4.240 
                 4.170 
                 −1.718 
               
               
                 104041000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:105760001- 
                 Gbp11 
                 2.452 
                 1.023 
                 4.045 
                 4.017 
                 4.000 
                 −1.548 
               
               
                 105761000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:111221001- 
                 Ulk1 
                 1.867 
                 2.023 
                 2.723 
                 3.017 
                 3.700 
                 −1.833 
               
               
                 111222000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:115544001- 
                 Sppl3 
                 2.867 
                 4.483 
                 4.308 
                 3.433 
                 3.907 
                 −1.040 
               
               
                 115545000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:117791001- 
                 Vsig10 
                 2.867 
                 4.023 
                 4.045 
                 3.754 
                 4.087 
                 −1.220 
               
               
                 117792000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:121770001- 
                 Gm15800 
                 2.867 
                 3.345 
                 3.723 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 121771000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:125044001- 
                 Gtf2h3 
                 2.452 
                 3.831 
                 3.308 
                 3.754 
                 3.700 
                 −1.248 
               
               
                 125045000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:135658001- 
                 Bcl7b 
                 0.867 
                 3.608 
                 3.308 
                 4.017 
                 4.087 
                 −3.220 
               
               
                 135659000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:136046001- 
                 Ccl24 
                 1.867 
                 4.023 
                 4.308 
                 4.240 
                 3.000 
                 −1.133 
               
               
                 136047000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:137871001- 
                 Zan 
                 1.867 
                 3.831 
                 1.571 
                 3.754 
                 3.700 
                 −1.833 
               
               
                 137872000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:138077001- 
                 Lrch4 
                 1.867 
                 4.023 
                 3.308 
                 2.433 
                 3.459 
                 −1.592 
               
               
                 138078000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:144095001- 
                 0610040B10Rik 
                 1.867 
                 3.608 
                 3.308 
                 3.433 
                 3.170 
                 −1.303 
               
               
                 144096000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:145519001- 
                 Tmem130 
                 2.452 
                 3.831 
                 2.723 
                 4.017 
                 3.807 
                 −1.355 
               
               
                 145520000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:145947001- 
                 Atp5j2 
                 2.452 
                 4.023 
                 2.723 
                 4.754 
                 3.459 
                 −1.007 
               
               
                 145948000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:146324001- 
                 Cyp3a41b 
                 3.452 
                 4.608 
                 5.183 
                 4.017 
                 4.459 
                 −1.007 
               
               
                 146325000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:24094001- 
                 Chpf2 
                 2.452 
                 3.608 
                 2.723 
                 4.754 
                 4.322 
                 −1.870 
               
               
                 24095000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:34117001- 
                 Letm1 
                 2.452 
                 3.831 
                 4.045 
                 3.017 
                 4.087 
                 −1.635 
               
               
                 34118000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:38444001- 
                 Stx18 
                 2.867 
                 3.023 
                 2.723 
                 4.433 
                 3.907 
                 −1.040 
               
               
                 38445000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:44443001- 
                 Prom1 
                 1.867 
                 3.608 
                 3.308 
                 2.433 
                 3.585 
                 −1.718 
               
               
                 44444000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:73720001- 
                 Ociad2 
                 2.452 
                 3.831 
                 2.723 
                 4.754 
                 3.459 
                 −1.007 
               
               
                 73721000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:76348001- 
                 Kdr 
                 2.452 
                 3.831 
                 1.723 
                 4.240 
                 3.807 
                 −1.355 
               
               
                 76349000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:87087001- 
                 Tmprss11bnl 
                 2.867 
                 2.023 
                 3.308 
                 4.433 
                 4.087 
                 −1.220 
               
               
                 87088000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:113015001- 
                 Thumpd3 
                 2.867 
                 3.608 
                 3.723 
                 4.892 
                 4.000 
                 −1.133 
               
               
                 113016000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:122882001- 
                 Clec4a1 
                 0.715 
                 3.608 
                 3.308 
                 3.754 
                 3.807 
                 −3.092 
               
               
                 122883000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:123007001- 
                 Clec4b1 
                 2.452 
                 3.608 
                 4.045 
                 4.017 
                 3.807 
                 −1.355 
               
               
                 123008000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:126779001- 
                 Ndufa9 
                 2.452 
                 4.345 
                 1.723 
                 4.240 
                 3.807 
                 −1.355 
               
               
                 126780000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:136707001- 
                 Gucy2c 
                 2.452 
                 3.831 
                 4.531 
                 1.433 
                 4.644 
                 −2.192 
               
               
                 136708000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:13905001- 
                 1110019D14Rik 
                 3.452 
                 4.483 
                 4.308 
                 4.602 
                 4.524 
                 −1.072 
               
               
                 13906000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:145083001- 
                 Lrmp 
                 1.867 
                 2.608 
                 2.723 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 145084000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:147023001- 
                 Gm5887 
                 2.452 
                 4.023 
                 4.045 
                 3.433 
                 3.459 
                 −1.007 
               
               
                 147024000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:29242001- 
                 Fam71f2 
                 2.452 
                 4.023 
                 3.308 
                 5.433 
                 3.459 
                 −1.007 
               
               
                 29243000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:49025001- 
                 2410003K15Rik 
                 2.867 
                 3.831 
                 4.308 
                 3.754 
                 4.248 
                 −1.381 
               
               
                 49026000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:72375001- 
                 Ggcx 
                 2.452 
                 4.483 
                 2.723 
                 4.433 
                 3.585 
                 −1.133 
               
               
                 72376000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:83432001- 
                 Dguok 
                 1.867 
                 4.345 
                 1.723 
                 3.433 
                 4.000 
                 −2.133 
               
               
                 83433000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:84528001- 
                 Cyp26b1 
                 2.452 
                 3.608 
                 4.045 
                 3.433 
                 3.700 
                 −1.248 
               
               
                 84529000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:86330001- 
                 Snrpg 
                 2.867 
                 3.023 
                 4.045 
                 4.892 
                 3.907 
                 −1.040 
               
               
                 86331000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:89133001- 
                 Gm6507 
                 1.867 
                 3.608 
                 3.723 
                 4.017 
                 3.459 
                 −1.592 
               
               
                 89134000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:100184001- 
                 Gm16744 
                 2.452 
                 3.608 
                 3.308 
                 3.754 
                 3.907 
                 −1.455 
               
               
                 100185000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:104485001- 
                 Kctd21 
                 1.867 
                 3.831 
                 3.308 
                 3.433 
                 3.170 
                 −1.303 
               
               
                 104486000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:108003001- 
                 Relt 
                 2.867 
                 3.831 
                 4.308 
                 3.754 
                 3.907 
                 −1.040 
               
               
                 108004000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:110567001- 
                 Usp17l5 
                 0.867 
                 3.608 
                 4.045 
                 4.017 
                 2.322 
                 −1.455 
               
               
                 110568000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:112704001- 
                 Smpd1 
                 0.867 
                 3.831 
                 4.045 
                 4.017 
                 2.585 
                 −1.718 
               
               
                 112705000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:11752001- 
                 Zscan4d 
                 1.867 
                 3.608 
                 2.723 
                 4.433 
                 3.000 
                 −1.133 
               
               
                 11753000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:123239001- 
                 1110004F10Rik 
                 0.867 
                 4.023 
                 4.723 
                 4.602 
                 3.585 
                 −2.718 
               
               
                 123240000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:128161001- 
                 Gm9234 
                 1.867 
                 4.193 
                 3.308 
                 3.754 
                 3.700 
                 −1.833 
               
               
                 128162000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:129300001- 
                 Gm15489 
                 1.867 
                 4.345 
                 3.308 
                 3.754 
                 3.000 
                 −1.133 
               
               
                 129301000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:133554001- 
                 Cd19 
                 2.867 
                 3.345 
                 4.045 
                 3.754 
                 3.907 
                 −1.040 
               
               
                 133555000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:134121001- 
                 Cdipt 
                 2.867 
                 4.930 
                 4.045 
                 4.433 
                 3.907 
                 −1.040 
               
               
                 134122000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:135045001- 
                 Bckdk 
                 0.867 
                 4.023 
                 3.308 
                 4.017 
                 3.907 
                 −3.040 
               
               
                 135046000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:135079001- 
                 Prss36 
                 1.867 
                 2.608 
                 1.23 
                 3.433 
                 3.459 
                 −1.592 
               
               
                 135080000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:147309001- 
                 Paox 
                 2.452 
                 3.831 
                 3.723 
                 4.017 
                 4.000 
                 −1.548 
               
               
                 147310000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:148036001- 
                 Odf3 
                 1.867 
                 4.608 
                 1.723 
                 4.433 
                 3.700 
                 −1.833 
               
               
                 148037000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:148133001- 
                 Athl1 
                 2.452 
                 3.608 
                 4.531 
                 3.433 
                 3.585 
                 −1.133 
               
               
                 148134000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:16808001- 
                 Dhx34 
                 1.867 
                 3.345 
                 3.723 
                 1.433 
                 3.907 
                 −2.040 
               
               
                 16809000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:17327001- 
                 Ap2s1 
                 1.867 
                 4.345 
                 4.308 
                 3.754 
                 4.000 
                 −2.133 
               
               
                 17328000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:20091001- 
                 Bloc1s3 
                 2.452 
                 2.608 
                 4.045 
                 3.017 
                 4.087 
                 −1.635 
               
               
                 20092000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:25381001- 
                 Ethe1 
                 3.452 
                 4.023 
                 3.308 
                 5.017 
                 4.524 
                 −1.072 
               
               
                 25382000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:26144001- 
                 Megf8 
                 2.452 
                 2.608 
                 3.723 
                 3.433 
                 3.459 
                 −1.007 
               
               
                 26145000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:27982001- 
                 BC024978 
                 1.867 
                 2.023 
                 2.723 
                 3.017 
                 3.459 
                 −1.592 
               
               
                 27983000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:29086001- 
                 Dll3 
                 1.867 
                 3.345 
                 3.308 
                 4.433 
                 3.459 
                 −1.592 
               
               
                 29087000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:31892001- 
                 Hpn 
                 2.452 
                 4.023 
                 1.571 
                 4.433 
                 3.585 
                 −1.133 
               
               
                 31893000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:4086001- 
                 Ttyh1 
                 0.867 
                 3.608 
                 3.723 
                 2.433 
                 3.170 
                 −2.303 
               
               
                 4087000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:4579001- 
                 Tmem86b 
                 2.867 
                 4.724 
                 4.045 
                 4.240 
                 4.000 
                 −1.133 
               
               
                 4580000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:4696001- 
                 Suv420h2 
                 2.452 
                 4.023 
                 3.308 
                 4.602 
                 3.459 
                 −1.007 
               
               
                 4697000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:50609001- 
                 Siglec5 
                 2.867 
                 3.345 
                 2.723 
                 4.433 
                 3.907 
                 −1.040 
               
               
                 50610000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:50706001- 
                 Etfb 
                 2.452 
                 4.193 
                 3.723 
                 3.433 
                 3.459 
                 −1.007 
               
               
                 50707000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:52032001- 
                 Vrk3 
                 2.452 
                 1.023 
                 2.723 
                 4.017 
                 3.585 
                 −1.133 
               
               
                 52033000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:52229001- 
                 Cpt1c 
                 2.867 
                 3.831 
                 4.045 
                 3.754 
                 3.907 
                 −1.040 
               
               
                 52230000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:71486001- 
                 Gm20457 
                 1.867 
                 4.193 
                 3.308 
                 3.433 
                 3.807 
                 −1.940 
               
               
                 71487000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:7243001- 
                 Clcn4-2 
                 1.867 
                 4.193 
                 3.723 
                 2.433 
                 3.807 
                 −1.940 
               
               
                 7244000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:86061001- 
                 Isg20 
                 2.452 
                 2.023 
                 4.045 
                 3.754 
                 3.700 
                 −1.248 
               
               
                 86062000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:86270001- 
                 Hapln3 
                 1.867 
                 4.831 
                 2.723 
                 3.754 
                 3.322 
                 −1.455 
               
               
                 86271000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:86529001- 
                 Rlbp1 
                 2.452 
                 3.345 
                 3.723 
                 3.433 
                 3.907 
                 −1.455 
               
               
                 86530000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:109919001- 
                 Nqo1 
                 2.452 
                 4.023 
                 4.045 
                 3.433 
                 3.907 
                 −1.455 
               
               
                 109920000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:12873001- 
                 Gm15347 
                 1.867 
                 3.023 
                 3.308 
                 2.433 
                 3.322 
                 −1.455 
               
               
                 12874000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:15039001- 
                 BB014433 
                 2.867 
                 3.345 
                 3.723 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 15040000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:54598001- 
                 Aga 
                 1.867 
                 2.608 
                 4.045 
                 3.754 
                 4.087 
                 −2.220 
               
               
                 54599000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:72279001- 
                 Gm20422 
                 1.867 
                 2.608 
                 2.723 
                 3.017 
                 4.000 
                 −2.133 
               
               
                 72280000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:72428001- 
                 Tssk6 
                 0.867 
                 3.345 
                 2.723 
                 1.433 
                 3.459 
                 −2.592 
               
               
                 72429000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:72857001- 
                 Upf1 
                 1.867 
                 4.193 
                 3.308 
                 2.433 
                 3.459 
                 −1.592 
               
               
                 72858000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:72895001- 
                 Comp 
                 1.867 
                 4.023 
                 2.723 
                 4.017 
                 3.700 
                 −1.833 
               
               
                 72896000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:73361001- 
                 Arrdc2 
                 2.452 
                 4.483 
                 4.045 
                 3.433 
                 4.170 
                 −1.718 
               
               
                 73362000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:74438001- 
                 Zfp882 
                 2.452 
                 4.193 
                 3.723 
                 4.240 
                 3.459 
                 −1.007 
               
               
                 74439000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:74716001- 
                 Hsh2d 
                 2.867 
                 2.023 
                 3.723 
                 4.433 
                 3.907 
                 −1.040 
               
               
                 74717000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:97646001- 
                 Kifc3 
                 2.452 
                 4.193 
                 2.723 
                 4.017 
                 3.907 
                 −1.455 
               
               
                 97647000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:98232001- 
                 Ndrg4 
                 2.452 
                 3.608 
                 3.308 
                 3.754 
                 3.907 
                 −1.455 
               
               
                 98233000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:100893001- 
                 Pccb 
                 2.867 
                 3.608 
                 4.308 
                 3.433 
                 4.248 
                 −1.381 
               
               
                 100894000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:106089001- 
                 Wdr82 
                 2.452 
                 4.023 
                 1.723 
                 4.240 
                 3.907 
                 −1.455 
               
               
                 106090000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:106371001- 
                 Parp3 
                 2.452 
                 3.831 
                 3.308 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 106372000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:107456001- 
                 Rassf1 
                 2.452 
                 2.023 
                 4.531 
                 2.433 
                 3.700 
                 −1.248 
               
               
                 107457000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:107833001- 
                 4921517D21Rik 
                 2.452 
                 3.608 
                 3.723 
                 3.433 
                 3.585 
                 −1.133 
               
               
                 107834000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:110522001- 
                 Nradd 
                 2.452 
                 4.345 
                 4.308 
                 3.017 
                 3.459 
                 −1.007 
               
               
                 110523000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:110627001- 
                 Pth1r 
                 1.867 
                 4.023 
                 2.723 
                 3.017 
                 3.322 
                 −1.455 
               
               
                 110628000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:119056001- 
                 Dlec1 
                 1.867 
                 2.608 
                 1.723 
                 3.433 
                 3.000 
                 −1.133 
               
               
                 119057000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:122809001- 
                 A530083I20Rik 
                 2.452 
                 3.345 
                 2.723 
                 4.017 
                 3.459 
                 −1.007 
               
               
                 122810000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:15041001- 
                 2200002K05Rik 
                 0.867 
                 4.023 
                 3.723 
                 4.240 
                 3.000 
                 −2.133 
               
               
                 15042000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:20148001- 
                 Zfp560 
                 1.867 
                 3.608 
                 4.045 
                 1.280 
                 3.000 
                 −1.133 
               
               
                 20149000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:44331001- 
                 Cxcr5 
                 2.452 
                 2.608 
                 3.723 
                 4.240 
                 3.907 
                 −1.455 
               
               
                 44332000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:50331001- 
                 Pts 
                 2.452 
                 3.831 
                 2.723 
                 5.240 
                 3.700 
                 −1.248 
               
               
                 50332000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:58058001- 
                 1600029O15Rik 
                 1.867 
                 3.345 
                 1.723 
                 3.754 
                 3.807 
                 −1.940 
               
               
                 58059000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:61217001- 
                 Gm10655 
                 2.452 
                 3.023 
                 4.045 
                 3.017 
                 3.700 
                 −1.248 
               
               
                 61218000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:61912001- 
                 Glce 
                 2.452 
                 3.023 
                 3.723 
                 3.754 
                 4.248 
                 −1.796 
               
               
                 61913000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:63485001- 
                 Aagab 
                 2.452 
                 3.023 
                 3.308 
                 4.017 
                 3.459 
                 −1.007 
               
               
                 63486000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:63968001- 
                 Lctl 
                 1.867 
                 4.345 
                 3.308 
                 3.017 
                 3.807 
                 −1.940 
               
               
                 63969000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:64184001- 
                 Dis3l 
                 2.867 
                 4.023 
                 4.308 
                 3.754 
                 3.907 
                 −1.040 
               
               
                 64185000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:98499001- 
                 Mrps22 
                 2.452 
                 4.608 
                 2.723 
                 4.754 
                 3.907 
                 −1.455 
               
               
                 98500000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 ChrX:103772001- 
                 Cysltr1 
                 1.867 
                 3.608 
                 4.045 
                 1.280 
                 3.000 
                 −1.133 
               
               
                 103773000 
                   
                   
                   
                   
                   
                   
                   
               
            
           
           
               
            
               
                 Gene body cleavage 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Chr1:107175001- 
                 Rnf152 
                 1.867 
                 3.023 
                 1.723 
                 3.433 
                 3.459 
                 −1.592 
               
               
                 107176000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:107691001- 
                 Tnfrsf11a 
                 2.867 
                 4.193 
                 4.308 
                 3.433 
                 3.322 
                 −0.455 
               
               
                 107692000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:129673001- 
                 Ccnt2 
                 1.867 
                 3.831 
                 2.723 
                 3.017 
                 3.585 
                 −1.718 
               
               
                 129674000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:133565001- 
                 Ctse 
                 2.452 
                 4.023 
                 3.308 
                 3.754 
                 4.000 
                 −1.548 
               
               
                 133566000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:134032001- 
                 Cdk18 
                 0.715 
                 3.831 
                 2.723 
                 2.433 
                 3.459 
                 −2.744 
               
               
                 134033000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:141450001- 
                 Cfhr1 
                 1.867 
                 3.023 
                 4.308 
                 4.240 
                 3.585 
                 −1.718 
               
               
                 141451000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:141645001- 
                 Gm4788 
                 3.189 
                 3.023 
                 4.045 
                 4.433 
                 4.858 
                 −1.669 
               
               
                 141646000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:153298001- 
                 1190005F20Rik 
                 1.867 
                 4.345 
                 4.045 
                 1.433 
                 3.807 
                 −1.940 
               
               
                 153299000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:172231001- 
                 Gm7694 
                 2.452 
                 3.345 
                 3.308 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 172232000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:173224001- 
                 Ufc1 
                 1.867 
                 4.483 
                 3.723 
                 4.433 
                 3.170 
                 −1.303 
               
               
                 173225000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:174416001- 
                 Igsf9 
                 0.867 
                 2.608 
                 3.308 
                 3.017 
                 3.170 
                 −2.303 
               
               
                 174417000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:21064001- 
                 Tram2 
                 1.867 
                 2.608 
                 1.723 
                 3.433 
                 3.585 
                 −1.718 
               
               
                 21065000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:34644001- 
                 Fam123c 
                 2.452 
                 2.608 
                 2.723 
                 4.017 
                 3.459 
                 −1.007 
               
               
                 34645000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:53002001- 
                 1700019D03Rik 
                 3.867 
                 4.023 
                 5.424 
                 4.240 
                 4.954 
                 −1.087 
               
               
                 53003000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:58000001- 
                 Spats2l 
                 1.867 
                 4.345 
                 3.308 
                 2.433 
                 4.170 
                 −2.303 
               
               
                 58001000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:58990001- 
                 Trak2 
                 3.452 
                 4.483 
                 4.045 
                 4.754 
                 5.129 
                 −1.677 
               
               
                 58991000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:74999001- 
                 Ihh 
                 2.867 
                 3.831 
                 4.045 
                 4.017 
                 4.170 
                 −1.303 
               
               
                 75000000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:75236001- 
                 Dnajb2 
                 1.867 
                 4.345 
                 4.723 
                 3.017 
                 3.700 
                 −1.833 
               
               
                 75237000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:75398001- 
                 Speg 
                 1.867 
                 3.831 
                 2.723 
                 3.017 
                 3.700 
                 −1.833 
               
               
                 75399000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:87793001- 
                 Itm2c 
                 2.452 
                 4.193 
                 2.723 
                 4.433 
                 3.459 
                 −1.007 
               
               
                 87794000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:87834001- 
                 4933407L21Rik 
                 2.452 
                 3.608 
                 3.308 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 87835000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:94805001- 
                 Dusp28 
                 1.867 
                 4.023 
                 3.723 
                 4.433 
                 3.000 
                 −1.133 
               
               
                 94806000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:95739001- 
                 D2hgdh 
                 2.867 
                 4.023 
                 4.531 
                 4.017 
                 4.907 
                 −2.040 
               
               
                 95740000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:103615001- 
                 Gm6763 
                 0.867 
                 2.023 
                 2.723 
                 3.017 
                 3.322 
                 −2.455 
               
               
                 103616000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:111631001- 
                 Caps2 
                 2.452 
                 4.345 
                 3.308 
                 3.754 
                 4.000 
                 −1.548 
               
               
                 111632000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:114787001- 
                 Tmem19 
                 1.867 
                 3.608 
                 4.045 
                 4.240 
                 4.087 
                 −2.220 
               
               
                 114788000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:119581001- 
                 Irak3 
                 1.867 
                 3.608 
                 3.723 
                 1.433 
                 3.459 
                 −1.592 
               
               
                 119582000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:126635001- 
                 F420014N23Rik 
                 2.452 
                 3.608 
                 2.723 
                 4.017 
                 3.585 
                 −1.133 
               
               
                 126636000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:126683001- 
                 Kif5a 
                 2.867 
                 3.023 
                 3.308 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 126684000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:128061001- 
                 Rps26 
                 2.452 
                 4.483 
                 3.308 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 128062000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:128113001- 
                 Rab5b 
                 2.452 
                 4.345 
                 4.045 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 128114000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:13219001- 
                 Fuca2 
                 1.867 
                 3.831 
                 1.723 
                 4.017 
                 3.170 
                 −1.303 
               
               
                 13220000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:34003001- 
                 Tspyl1 
                 2.452 
                 3.345 
                 3.723 
                 3.754 
                 3.700 
                 −1.248 
               
               
                 34004000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:42409001- 
                 Ostm1 
                 3.452 
                 3.345 
                 4.045 
                 4.754 
                 3.907 
                 −0.455 
               
               
                 42410000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:43669001- 
                 Aim1 
                 1.867 
                 4.023 
                 2.723 
                 3.017 
                 3.585 
                 −1.718 
               
               
                 43670000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:52153001- 
                 Nus1 
                 2.452 
                 4.345 
                 4.045 
                 3.433 
                 3.459 
                 −1.007 
               
               
                 52154000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:59184001- 
                 Cbara1 
                 2.867 
                 4.483 
                 3.723 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 59185000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:70798001- 
                 Cisd1 
                 1.867 
                 3.345 
                 1.571 
                 4.017 
                 3.170 
                 −1.303 
               
               
                 70799000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:75244001- 
                 Gstt3 
                 1.867 
                 3.345 
                 3.308 
                 3.433 
                 3.170 
                 −1.303 
               
               
                 75245000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:77661001- 
                 Trappc10 
                 2.867 
                 3.608 
                 4.045 
                 3.754 
                 3.907 
                 −1.040 
               
               
                 77662000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:78995001- 
                 Ppap2c 
                 0.867 
                 1.023 
                 1.723 
                 3.017 
                 3.170 
                 −2.303 
               
               
                 78996000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:79382001- 
                 Kiss1r 
                 1.867 
                 3.023 
                 2.723 
                 3.433 
                 3.807 
                 −1.940 
               
               
                 79383000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:79497001- 
                 Polr2e 
                 1.867 
                 4.023 
                 4.045 
                 3.017 
                 3.459 
                 −1.592 
               
               
                 79498000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:79757001- 
                 Rps15 
                 2.452 
                 3.831 
                 4.045 
                 3.017 
                 3.807 
                 −1.355 
               
               
                 79758000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:79850001- 
                 Mex3d 
                 0.867 
                 3.023 
                 1.723 
                 3.754 
                 2.807 
                 −1.940 
               
               
                 79851000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:80049001- 
                 Fam108a 
                 1.867 
                 4.345 
                 4.893 
                 3.433 
                 3.170 
                 −1.303 
               
               
                 80050000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:80496001- 
                 Slc39a3 
                 1.867 
                 2.608 
                 4.045 
                 4.433 
                 3.170 
                 −1.303 
               
               
                 80497000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:80609001- 
                 Zbtb7a 
                 1.867 
                 3.023 
                 4.045 
                 2.433 
                 3.000 
                 −1.133 
               
               
                 80610000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:81002001- 
                 Gna11 
                 1.867 
                 4.023 
                 1.723 
                 3.754 
                 3.170 
                 −1.303 
               
               
                 81003000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:81155001- 
                 Gm8112 
                 1.867 
                 2.608 
                 2.723 
                 3.017 
                 3.000 
                 −1.133 
               
               
                 81156000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:93604001- 
                 Fgd6 
                 3.189 
                 3.831 
                 4.045 
                 4.433 
                 4.322 
                 −1.133 
               
               
                 93605000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:100555001- 
                 Gm11547 
                 2.452 
                 4.193 
                 2.723 
                 4.017 
                 4.000 
                 −1.548 
               
               
                 100556000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:100684001- 
                 Stat5b 
                 2.452 
                 3.345 
                 3.723 
                 3.433 
                 4.248 
                 −1.796 
               
               
                 100685000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:101030001- 
                 Plekhh3 
                 2.452 
                 1.023 
                 4.045 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 101031000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:102084001- 
                 Hdac5 
                 2.867 
                 3.608 
                 3.723 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 102085000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:102145001- 
                 Tmub2 
                 3.452 
                 3.345 
                 4.308 
                 4.754 
                 4.459 
                 −1.007 
               
               
                 102146000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:102981001- 
                 Hexim1 
                 2.452 
                 3.831 
                 2.723 
                 4.017 
                 4.000 
                 −1.548 
               
               
                 102982000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:104458001- 
                 Myl4 
                 1.867 
                 3.608 
                 4.045 
                 1.433 
                 4.000 
                 −2.133 
               
               
                 104459000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:105884001- 
                 Kcnh6 
                 2.867 
                 3.831 
                 4.308 
                 3.433 
                 3.907 
                 −1.040 
               
               
                 105885000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:106196001- 
                 Scn4a 
                 2.452 
                 4.345 
                 3.308 
                 3.754 
                 3.700 
                 −1.248 
               
               
                 106197000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:107482001- 
                 Helz 
                 3.189 
                 3.608 
                 4.531 
                 4.017 
                 4.644 
                 −1.455 
               
               
                 107483000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:109449001- 
                 Wipi1 
                 2.452 
                 3.023 
                 3.723 
                 3.433 
                 3.700 
                 −1.248 
               
               
                 109450000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:110261001- 
                 Map2k6 
                 2.867 
                 3.023 
                 4.893 
                 1.433 
                 3.270 
                 −0.403 
               
               
                 110262000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:115469001- 
                 Mrps7 
                 1.867 
                 3.023 
                 3.723 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 115470000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:116155001- 
                 Exoc7 
                 1.867 
                 3.345 
                 4.045 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 116156000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:116394001- 
                 Sphk1 
                 1.867 
                 2.608 
                 1.723 
                 4.017 
                 3.322 
                 −1.455 
               
               
                 116395000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:117477001- 
                 2900041M22Rik 
                 1.867 
                 4.023 
                 4.045 
                 3.754 
                 3.000 
                 −1.133 
               
               
                 117478000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:117670001- 
                 Syngr2 
                 1.867 
                 3.345 
                 1.723 
                 4.433 
                 3.459 
                 −1.592 
               
               
                 117671000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:118033001- 
                 Cyth1 
                 1.867 
                 4.345 
                 1.571 
                 3.754 
                 3.585 
                 −1.718 
               
               
                 118034000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:118899001- 
                 Cbx8 
                 0.867 
                 4.023 
                 3.723 
                 4.433 
                 3.459 
                 −2.592 
               
               
                 118900000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:120210001- 
                 0610009L18Rik 
                 1.867 
                 3.608 
                 3.308 
                 2.433 
                 3.000 
                 −1.133 
               
               
                 120211000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:120352001- 
                 Gm11788 
                 1.867 
                 2.608 
                 2.723 
                 3.017 
                 3.322 
                 −1.455 
               
               
                 120353000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:120410001- 
                 Fam195b 
                 1.867 
                 4.193 
                 3.308 
                 3.433 
                 3.585 
                 −1.718 
               
               
                 120411000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:120474001- 
                 Pcyt2 
                 1.867 
                 2.608 
                 1.723 
                 3.754 
                 3.000 
                 −1.133 
               
               
                 120475000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:20101001- 
                 Rab1 
                 1.867 
                 3.345 
                 1.723 
                 3.433 
                 3.585 
                 −1.718 
               
               
                 20102000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:21903001- 
                 Otx1 
                 2.452 
                 3.345 
                 3.308 
                 3.754 
                 3.700 
                 −1.248 
               
               
                 21904000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:3202001- 
                 Patz1 
                 2.867 
                 2.023 
                 4.531 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 3203000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:3823001- 
                 Tcn2 
                 2.452 
                 4.023 
                 3.308 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 3824000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:3991001- 
                 Mtfp1 
                 1.867 
                 4.193 
                 3.723 
                 3.754 
                 3.700 
                 −1.833 
               
               
                 3992000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:3996001- 
                 Sec14l2 
                 2.452 
                 3.608 
                 4.531 
                 2.433 
                 3.585 
                 −1.133 
               
               
                 3997000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:4171001- 
                 Lif 
                 1.867 
                 2.023 
                 3.723 
                 1.433 
                 4.000 
                 −2.133 
               
               
                 4172000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:4644001- 
                 Cabp7 
                 2.452 
                 4.483 
                 4.308 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 4645000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:51432001- 
                 Nhp2 
                 1.867 
                 3.831 
                 3.308 
                 3.017 
                 3.585 
                 −1.718 
               
               
                 51433000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:51459001- 
                 N4bp3 
                 2.452 
                 5.023 
                 4.045 
                 4.433 
                 3.907 
                 −1.455 
               
               
                 51460000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:53431001- 
                 Il4 
                 1.867 
                 1.023 
                 3.308 
                 3.433 
                 3.585 
                 −1.718 
               
               
                 53432000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:5768001- 
                 Aebp1 
                 2.867 
                 4.193 
                 4.531 
                 3.017 
                 3.907 
                 −1.040 
               
               
                 5769000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:58972001- 
                 A230051G13Rik 
                 0.867 
                 3.345 
                 3.723 
                 3.433 
                 3.585 
                 −2.718 
               
               
                 58973000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:59022001- 
                 2310033P09Rik 
                 1.867 
                 3.345 
                 4.045 
                 1.433 
                 3.170 
                 −1.303 
               
               
                 59023000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:59144001- 
                 Wnt9a 
                 1.867 
                 3.345 
                 1.723 
                 3.433 
                 3.907 
                 −2.040 
               
               
                 59145000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:59475001- 
                 Mprip 
                 1.867 
                 3.608 
                 3.723 
                 1.433 
                 3.459 
                 −1.592 
               
               
                 59476000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:59603001- 
                 Flcn 
                 2.867 
                 3.608 
                 4.308 
                 3.433 
                 4.248 
                 −1.381 
               
               
                 59604000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:61307001- 
                 Mapk7 
                 0.867 
                 1.023 
                 2.723 
                 3.754 
                 2.322 
                 −1.455 
               
               
                 61308000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:62090001- 
                 Zswim7 
                 1.867 
                 4.483 
                 3.723 
                 3.433 
                 3.459 
                 −1.592 
               
               
                 62091000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:6492001- 
                 Ccm2 
                 3.189 
                 3.345 
                 3.723 
                 4.602 
                 4.524 
                 −1.335 
               
               
                 6493000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:66842001- 
                 Tmem220 
                 1.867 
                 3.608 
                 4.045 
                 4.017 
                 3.459 
                 −1.592 
               
               
                 66843000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:67777001- 
                 Wdr16 
                 2.452 
                 4.345 
                 2.723 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 67778000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:68902001- 
                 Vamp2 
                 1.867 
                 0.871 
                 2.723 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 68903000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:69171001- 
                 Chd3 
                 1.867 
                 3.345 
                 3.723 
                 1.433 
                 3.585 
                 −1.718 
               
               
                 69172000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:69630001- 
                 4933402P03Rik 
                 2.452 
                 3.608 
                 4.045 
                 3.433 
                 3.585 
                 −1.133 
               
               
                 69631000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:69756001- 
                 Slc2a4 
                 0.867 
                 3.608 
                 3.308 
                 1.280 
                 3.459 
                 −2.592 
               
               
                 69757000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:70052001- 
                 Rnasek 
                 1.867 
                 3.023 
                 4.893 
                 4.240 
                 3.000 
                 −1.133 
               
               
                 70053000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:70707001- 
                 Rabep1 
                 2.867 
                 4.608 
                 3.723 
                 4.017 
                 4.170 
                 −1.303 
               
               
                 70708000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:72212001- 
                 Smtnl2 
                 1.867 
                 2.608 
                 2.723 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 72213000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:72248001- 
                 Ggt6 
                 2.452 
                 3.345 
                 2.723 
                 4.240 
                 3.585 
                 −1.133 
               
               
                 72249000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:74449001- 
                 E130309D14Rik 
                 2.452 
                 4.345 
                 3.723 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 74450000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:78003001- 
                 Rab34 
                 1.867 
                 3.023 
                 4.045 
                 3.754 
                 4.170 
                 −2.303 
               
               
                 78004000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:78138001- 
                 Aldoc 
                 2.452 
                 4.023 
                 3.723 
                 3.754 
                 4.087 
                 −1.635 
               
               
                 78139000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:79965001- 
                 Adap2 
                 2.867 
                 3.831 
                 2.723 
                 4.602 
                 4.000 
                 −1.133 
               
               
                 79966000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:82832001- 
                 Slfn8 
                 2.867 
                 3.608 
                 4.308 
                 3.433 
                 3.907 
                 −1.040 
               
               
                 82833000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:94642001- 
                 Tmem92-ps 
                 2.452 
                 3.608 
                 3.308 
                 4.240 
                 3.700 
                 −1.248 
               
               
                 94643000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:95007001- 
                 Dlx4 
                 2.452 
                 2.608 
                 1.723 
                 4.240 
                 3.459 
                 −1.007 
               
               
                 95008000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:95130001- 
                 Tac4 
                 2.452 
                 4.193 
                 4.531 
                 4.017 
                 3.907 
                 −1.455 
               
               
                 95131000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:96144001- 
                 Hoxb8 
                 0.867 
                 3.023 
                 3.308 
                 2.433 
                 2.807 
                 −1.940 
               
               
                 96145000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:97885001- 
                 Gm11629 
                 2.867 
                 3.831 
                 3.308 
                 4.240 
                 4.000 
                 −1.133 
               
               
                 97886000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:98218001- 
                 Ppp1r1b 
                 2.452 
                 3.345 
                 2.723 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 98219000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:102323001- 
                 D130020L05Rik 
                 1.867 
                 3.345 
                 2.723 
                 3.433 
                 3.585 
                 −1.718 
               
               
                 102324000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:110854001- 
                 Rian 
                 1.867 
                 3.345 
                 3.308 
                 3.017 
                 3.700 
                 −1.833 
               
               
                 110855000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:111764001- 
                 Ppp2r5c 
                 2.867 
                 3.023 
                 4.308 
                 3.433 
                 3.907 
                 −1.040 
               
               
                 111765000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:112812001- 
                 2810029C07Rik 
                 1.867 
                 2.608 
                 4.045 
                 2.433 
                 3.807 
                 −1.940 
               
               
                 112813000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:112946001- 
                 Bag5 
                 2.452 
                 1.023 
                 3.308 
                 3.754 
                 3.907 
                 −1.455 
               
               
                 112947000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:113921001- 
                 Zbtb42 
                 0.867 
                 3.345 
                 1.723 
                 3.017 
                 3.000 
                 −2.133 
               
               
                 113922000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:114178001- 
                 Nudt14 
                 1.867 
                 4.193 
                 4.045 
                 3.017 
                 3.322 
                 −1.455 
               
               
                 114179000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:114279001- 
                 Pacs2 
                 2.867 
                 4.193 
                 3.308 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 114280000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:114383001- 
                 Crip2 
                 1.867 
                 3.831 
                 2.723 
                 3.433 
                 3.459 
                 −1.592 
               
               
                 114384000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:25178001- 
                 Gm16372 
                 1.867 
                 3.831 
                 1.723 
                 4.433 
                 3.459 
                 −1.592 
               
               
                 25179000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:25670001- 
                 Kidins220 
                 2.867 
                 2.608 
                 4.531 
                 3.017 
                 3.907 
                 −1.040 
               
               
                 25671000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:25782001- 
                 Id2 
                 1.867 
                 3.345 
                 4.045 
                 2.433 
                 3.000 
                 −1.133 
               
               
                 25783000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:36911001- 
                 Ankmy2 
                 2.867 
                 2.023 
                 2.723 
                 4.433 
                 4.000 
                 −1.133 
               
               
                 36912000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:45585001- 
                 Nrcam 
                 3.452 
                 4.023 
                 4.723 
                 4.240 
                 4.459 
                 −1.007 
               
               
                 45586000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:71068001- 
                 Gm3086 
                 2.452 
                 4.193 
                 3.308 
                 4.892 
                 4.087 
                 −1.635 
               
               
                 71069000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:80245001- 
                 Arg2 
                 3.189 
                 3.345 
                 4.308 
                 4.433 
                 4.459 
                 −1.270 
               
               
                 80246000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:80271001- 
                 Vti1b 
                 2.867 
                 3.831 
                 3.308 
                 5.017 
                 4.087 
                 −1.220 
               
               
                 80272000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:81230001- 
                 2310015A10Rik 
                 2.452 
                 4.023 
                 4.045 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 81231000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:102470001- 
                 Pik3r1 
                 3.189 
                 4.023 
                 4.723 
                 4.017 
                 3.585 
                 −0.396 
               
               
                 102471000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:103498001- 
                 Cd180 
                 1.867 
                 4.193 
                 2.723 
                 3.017 
                 3.807 
                 −1.940 
               
               
                 103499000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:21923001- 
                 Hist1h4n 
                 1.867 
                 3.831 
                 3.308 
                 3.754 
                 3.000 
                 −1.133 
               
               
                 21924000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:23858001- 
                 Hist1h1a 
                 2.452 
                 2.608 
                 3.308 
                 3.754 
                 3.585 
                 −1.133 
               
               
                 23859000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:33416001- 
                 Serpinb9f 
                 1.867 
                 3.608 
                 2.723 
                 3.433 
                 3.807 
                 −1.940 
               
               
                 33417000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:35011001- 
                 1700026J04Rik 
                 0.715 
                 3.608 
                 4.723 
                 1.280 
                 3.322 
                 −2.607 
               
               
                 35012000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:43635001- 
                 Ccdc90a 
                 1.867 
                 2.608 
                 3.308 
                 3.433 
                 3.459 
                 −1.592 
               
               
                 43636000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:45501001- 
                 Mylip 
                 2.867 
                 3.345 
                 4.045 
                 4.017 
                 4.000 
                 −1.133 
               
               
                 45502000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:46061001- 
                 5033430I15Rik 
                 0.867 
                 3.608 
                 3.308 
                 4.017 
                 2.585 
                 −1.718 
               
               
                 46062000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:53063001- 
                 Nfil3 
                 1.867 
                 3.345 
                 2.723 
                 3.433 
                 4.000 
                 −2.133 
               
               
                 53064000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:54483001- 
                 Cplx2 
                 1.867 
                 1.023 
                 1.723 
                 3.433 
                 3.000 
                 −1.133 
               
               
                 54484000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:54797001- 
                 Rnf44 
                 2.867 
                 4.023 
                 4.045 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 54798000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:54826001- 
                 Cdhr2 
                 2.452 
                 3.345 
                 4.308 
                 2.433 
                 3.907 
                 −1.455 
               
               
                 54827000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:59755001- 
                 Golm1 
                 1.867 
                 4.023 
                 4.045 
                 3.754 
                 3.700 
                 −1.833 
               
               
                 59756000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:62318001- 
                 Gm17352 
                 2.452 
                 3.831 
                 4.531 
                 3.433 
                 3.807 
                 −1.355 
               
               
                 62319000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:74176001- 
                 Cep72 
                 2.452 
                 4.345 
                 2.723 
                 4.433 
                 3.585 
                 −1.133 
               
               
                 74177000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:9110001- 
                 Larp4b 
                 4.567 
                 5.023 
                 5.630 
                 5.520 
                 6.209 
                 −1.642 
               
               
                 9111000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:120903001- 
                 Rap2a 
                 1.867 
                 3.831 
                 2.723 
                 3.754 
                 3.700 
                 −1.833 
               
               
                 120904000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:21132001- 
                 Nudt13 
                 2.867 
                 3.831 
                 3.723 
                 4.017 
                 4.170 
                 −1.303 
               
               
                 21133000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:25312001- 
                 Rps24 
                 2.452 
                 4.608 
                 1.723 
                 4.433 
                 3.700 
                 −1.248 
               
               
                 25313000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:26280001- 
                 D930049A15Rik 
                 0.867 
                 3.345 
                 2.723 
                 3.433 
                 2.807 
                 −1.940 
               
               
                 26281000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:26695001- 
                 Anxa11 
                 0.715 
                 2.608 
                 1.571 
                 3.017 
                 2.000 
                 −1.285 
               
               
                 26696000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:32906001- 
                 Oxnad1 
                 2.452 
                 2.023 
                 3.723 
                 3.433 
                 3.459 
                 −1.007 
               
               
                 32907000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:35128001- 
                 Glud1 
                 2.452 
                 3.608 
                 1.723 
                 4.433 
                 3.585 
                 −1.133 
               
               
                 35129000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:35367001- 
                 Ldb3 
                 2.867 
                 4.193 
                 4.531 
                 3.433 
                 4.248 
                 −1.381 
               
               
                 35368000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:48699001- 
                 Gm6055 
                 0.867 
                 4.608 
                 3.308 
                 4.433 
                 3.585 
                 −2.718 
               
               
                 48700000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:52529001- 
                 Ndrg2 
                 2.452 
                 3.831 
                 3.308 
                 3.754 
                 4.000 
                 −1.548 
               
               
                 52530000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:54857001- 
                 Dad1 
                 1.867 
                 3.023 
                 2.723 
                 3.433 
                 3.170 
                 −1.303 
               
               
                 54858000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:54983001- 
                 Oxa1l 
                 2.452 
                 3.023 
                 2.723 
                 4.433 
                 3.585 
                 −1.133 
               
               
                 54984000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:55233001- 
                 Psmb5 
                 2.452 
                 4.345 
                 3.308 
                 4.240 
                 3.700 
                 −1.248 
               
               
                 55234000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:56280001- 
                 Nedd8 
                 2.452 
                 3.023 
                 4.531 
                 4.240 
                 3.700 
                 −1.248 
               
               
                 56281000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:58448001- 
                 Mrp63 
                 1.867 
                 3.608 
                 3.308 
                 4.240 
                 3.585 
                 −1.718 
               
               
                 58449000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:73922001- 
                 Nudt15 
                 2.452 
                 3.608 
                 3.308 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 73923000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:100958001- 
                 Acvrl1 
                 2.452 
                 3.023 
                 2.723 
                 4.240 
                 4.087 
                 −1.635 
               
               
                 100959000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:102983001- 
                 Smug1 
                 2.867 
                 3.608 
                 4.045 
                 3.754 
                 4.000 
                 −1.133 
               
               
                 102984000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:6559001- 
                 Fyb 
                 2.867 
                 3.831 
                 3.308 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 6560000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:66816001- 
                 Gm2895 
                 2.452 
                 1.023 
                 2.723 
                 4.017 
                 3.907 
                 −1.455 
               
               
                 66817000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:74409001- 
                 Bai1 
                 2.452 
                 3.345 
                 3.723 
                 3.433 
                 3.700 
                 −1.248 
               
               
                 74410000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:74503001- 
                 Arc 
                 2.452 
                 4.023 
                 3.308 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 74504000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:76174001- 
                 Cyc1 
                 0.867 
                 3.023 
                 2.723 
                 4.240 
                 2.807 
                 −1.940 
               
               
                 76175000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:76364001- 
                 Fbxl6 
                 0.867 
                 2.023 
                 1.723 
                 3.433 
                 2.322 
                 −1.455 
               
               
                 76365000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:78387001- 
                 Rac2 
                 2.452 
                 4.193 
                 1.723 
                 4.240 
                 3.807 
                 −1.355 
               
               
                 78388000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:78818001- 
                 Triobp 
                 2.867 
                 2.608 
                 3.723 
                 4.017 
                 4.170 
                 −1.303 
               
               
                 78819000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:79555001- 
                 Sun2 
                 1.867 
                 3.345 
                 2.723 
                 3.017 
                 3.000 
                 −1.133 
               
               
                 79556000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:80077001- 
                 Smcr7l 
                 2.867 
                 3.608 
                 3.308 
                 4.433 
                 4.087 
                 −1.220 
               
               
                 80078000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:82168001- 
                 Naga 
                 1.867 
                 3.345 
                 3.308 
                 3.433 
                 3.170 
                 −1.303 
               
               
                 82169000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:83416001- 
                 Ttll12 
                 2.867 
                 3.831 
                 4.531 
                 4.433 
                 4.087 
                 −1.220 
               
               
                 83417000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:85403001- 
                 Wnt7b 
                 1.867 
                 3.831 
                 2.723 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 85404000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:97727001- 
                 Vdr 
                 1.867 
                 3.345 
                 1.723 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 97728000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:99222001- 
                 Tmbim6 
                 1.867 
                 4.724 
                 3.308 
                 4.240 
                 3.170 
                 −1.303 
               
               
                 99223000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:99335001- 
                 Faim2 
                 1.867 
                 3.345 
                 3.308 
                 4.017 
                 3.322 
                 −1.455 
               
               
                 99336000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:99544001- 
                 Smarcd1 
                 2.452 
                 4.193 
                 3.723 
                 3.754 
                 4.000 
                 −1.548 
               
               
                 99545000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:18423001- 
                 Comt 
                 2.867 
                 4.023 
                 3.723 
                 4.433 
                 4.087 
                 −1.220 
               
               
                 18424000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:32161001- 
                 Lrrc33 
                 2.867 
                 3.831 
                 4.531 
                 3.017 
                 3.907 
                 −1.040 
               
               
                 32162000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:38574001- 
                 Tmem39a 
                 2.452 
                 4.345 
                 3.723 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 38575000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:45119001- 
                 Ccdc80 
                 2.867 
                 2.608 
                 4.045 
                 3.754 
                 4.087 
                 −1.220 
               
               
                 45120000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:4624001- 
                 Glis2 
                 2.867 
                 4.608 
                 4.045 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 4625000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:4698001- 
                 Dnaja3 
                 2.867 
                 4.930 
                 3.308 
                 4.240 
                 4.170 
                 −1.303 
               
               
                 4699000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:49800001- 
                 Gm16619 
                 2.452 
                 3.608 
                 3.723 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 49801000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:52029001- 
                 Cblb 
                 3.452 
                 4.193 
                 4.893 
                 4.017 
                 4.000 
                 −0.548 
               
               
                 52030000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:70373001- 
                 Gbe1 
                 2.867 
                 3.608 
                 4.893 
                 1.433 
                 4.807 
                 −1.940 
               
               
                 70374000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:8635001- 
                 Tmem186 
                 2.452 
                 3.345 
                 4.723 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 8636000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:93682001- 
                 Cbr3 
                 2.452 
                 2.608 
                 3.723 
                 4.433 
                 3.807 
                 −1.355 
               
               
                 93683000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:95933001- 
                 Ets2 
                 1.867 
                 3.023 
                 4.045 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 95934000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:96428001- 
                 Sh3bgr 
                 2.867 
                 4.193 
                 4.045 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 96429000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:24826001- 
                 Syngr3 
                 0.715 
                 3.345 
                 4.531 
                 3.017 
                 2.322 
                 −1.607 
               
               
                 24827000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:33074001- 
                 Cyp4f13 
                 2.452 
                 3.608 
                 3.308 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 33075000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:34046001- 
                 BC051226 
                 1.867 
                 1.023 
                 3.308 
                 2.433 
                 3.585 
                 −1.718 
               
               
                 34047000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:34087001- 
                 B3galt4 
                 1.867 
                 3.345 
                 3.723 
                 1.433 
                 3.700 
                 −1.833 
               
               
                 34088000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:34104001- 
                 Vps52 
                 2.452 
                 4.345 
                 3.723 
                 4.754 
                 3.459 
                 −1.007 
               
               
                 34105000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:34449001- 
                 H2-Eb1 
                 1.867 
                 3.831 
                 1.723 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 34450000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:34865001- 
                 C4b 
                 2.867 
                 3.023 
                 3.723 
                 4.017 
                 4.087 
                 −1.220 
               
               
                 34866000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:35164001- 
                 Ng23 
                 0.867 
                 3.023 
                 1.571 
                 3.754 
                 3.807 
                 −2.940 
               
               
                 35165000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:35331001- 
                 Ltb 
                 1.867 
                 2.023 
                 3.308 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 35332000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:36598001- 
                 H2-M10.4 
                 1.867 
                 3.023 
                 2.723 
                 3.754 
                 3.700 
                 −1.833 
               
               
                 36599000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:47577001- 
                 AI661453 
                 2.452 
                 3.831 
                 4.531 
                 2.433 
                 3.459 
                 −1.007 
               
               
                 47578000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:56929001- 
                 Rfx2 
                 1.867 
                 3.023 
                 2.723 
                 3.017 
                 3.585 
                 −1.718 
               
               
                 56930000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:57200001- 
                 Crb3 
                 2.452 
                 3.831 
                 4.045 
                 4.017 
                 3.807 
                 −1.355 
               
               
                 57201000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:35023001- 
                 Egr1 
                 2.452 
                 3.608 
                 4.531 
                 3.433 
                 3.459 
                 −1.007 
               
               
                 35024000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:36127001- 
                 Psd2 
                 1.867 
                 3.608 
                 1.723 
                 3.433 
                 3.807 
                 −1.940 
               
               
                 36128000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:39542001- 
                 Gm15337 
                 2.452 
                 3.345 
                 3.308 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 39543000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:43476001- 
                 Stk32a 
                 1.867 
                 4.023 
                 3.308 
                 2.433 
                 3.170 
                 −1.303 
               
               
                 43477000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:4668001- 
                 9430020K01Rik 
                 1.867 
                 3.023 
                 1.723 
                 3.433 
                 3.000 
                 −1.133 
               
               
                 4669000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:48206001- 
                 Gm5506 
                 2.452 
                 4.193 
                 2.723 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 48207000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:54144001- 
                 Gm5507 
                 2.452 
                 3.345 
                 4.045 
                 4.892 
                 4.000 
                 −1.548 
               
               
                 54145000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:60728001- 
                 Rbm22 
                 2.452 
                 4.023 
                 4.045 
                 3.433 
                 3.585 
                 −1.133 
               
               
                 60729000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:61210001- 
                 Pdgfrb 
                 1.867 
                 3.023 
                 1.571 
                 3.754 
                 3.459 
                 −1.592 
               
               
                 61211000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:67485001- 
                 B430212C06Rik 
                 2.452 
                 3.023 
                 1.571 
                 4.433 
                 4.170 
                 −1.718 
               
               
                 67486000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:70178001- 
                 Rab27b 
                 1.867 
                 3.023 
                 2.723 
                 3.017 
                 3.459 
                 −1.592 
               
               
                 70179000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:75120001- 
                 Lipg 
                 2.452 
                 4.023 
                 4.045 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 75121000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr18:75162001- 
                 Rpl17 
                 2.867 
                 4.483 
                 4.531 
                 3.017 
                 4.087 
                 −1.220 
               
               
                 75163000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:21346001- 
                 Zfand5 
                 0.867 
                 2.608 
                 2.723 
                 3.433 
                 2.585 
                 −1.718 
               
               
                 21347000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:24416001- 
                 Pip5k1b 
                 1.867 
                 2.608 
                 1.723 
                 3.433 
                 4.000 
                 −2.133 
               
               
                 24417000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:29031001- 
                 4430402I18Rik 
                 2.452 
                 3.023 
                 4.308 
                 2.433 
                 3.807 
                 −1.355 
               
               
                 29032000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:3899001- 
                 Tcirg1 
                 2.452 
                 4.345 
                 3.308 
                 3.754 
                 4.000 
                 −1.548 
               
               
                 3900000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:4171001- 
                 Carns1 
                 1.867 
                 3.831 
                 1.723 
                 3.433 
                 3.585 
                 −1.718 
               
               
                 4172000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:4195001- 
                 Ppp1ca 
                 2.452 
                 4.023 
                 4.045 
                 3.017 
                 4.585 
                 −2.133 
               
               
                 4196000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:45065001- 
                 Sema4g 
                 2.452 
                 3.831 
                 2.723 
                 4.017 
                 4.000 
                 −1.548 
               
               
                 45066000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:45093001- 
                 Lzts2 
                 1.867 
                 3.023 
                 3.308 
                 3.754 
                 3.459 
                 −1.592 
               
               
                 45094000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:46402001- 
                 Fbxl15 
                 2.867 
                 4.023 
                 2.723 
                 4.602 
                 3.907 
                 −1.040 
               
               
                 46403000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:46743001- 
                 Cyp17a1 
                 1.867 
                 3.345 
                 2.723 
                 3.754 
                 3.585 
                 −1.718 
               
               
                 46744000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:4863001- 
                 Actn3 
                 2.867 
                 4.023 
                 3.308 
                 4.433 
                 3.907 
                 −1.040 
               
               
                 4864000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:4930001- 
                 Peli3 
                 1.867 
                 4.193 
                 3.723 
                 2.433 
                 3.807 
                 −1.940 
               
               
                 4931000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:5038001- 
                 B3gnt1 
                 0.867 
                 3.608 
                 2.723 
                 4.240 
                 3.000 
                 −2.133 
               
               
                 5039000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:5116001- 
                 Klc2 
                 2.452 
                 4.023 
                 2.723 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 5117000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:5388001- 
                 Sart1 
                 0.867 
                 4.023 
                 2.723 
                 1.433 
                 2.807 
                 −1.940 
               
               
                 5389000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:5425001- 
                 AI837181 
                 1.867 
                 4.023 
                 4.045 
                 3.433 
                 3.459 
                 −1.592 
               
               
                 5426000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:5480001- 
                 Efemp2 
                 1.867 
                 4.483 
                 2.723 
                 3.017 
                 3.459 
                 −1.592 
               
               
                 5481000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:57436001- 
                 Fam160b1 
                 0.867 
                 3.023 
                 3.723 
                 1.280 
                 2.807 
                 −1.940 
               
               
                 57437000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:5754001- 
                 Ltbp3 
                 2.452 
                 3.345 
                 3.723 
                 3.754 
                 4.170 
                 −1.718 
               
               
                 5755000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:59336001- 
                 Slc18a2 
                 2.867 
                 3.831 
                 4.045 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 59337000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:6084001- 
                 Zfpl1 
                 0.867 
                 3.608 
                 2.723 
                 3.433 
                 3.000 
                 −2.133 
               
               
                 6085000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:6108001- 
                 Naaladl1 
                 2.452 
                 3.831 
                 3.308 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 6109000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:6399001- 
                 Rasgrp2 
                 0.715 
                 1.023 
                 3.308 
                 3.017 
                 3.000 
                 −2.285 
               
               
                 6400000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:6981001- 
                 Prdx5 
                 1.867 
                 3.023 
                 4.045 
                 4.433 
                 3.807 
                 −1.940 
               
               
                 6982000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:7044001- 
                 Plcb3 
                 1.867 
                 2.023 
                 3.308 
                 2.433 
                 3.000 
                 −1.133 
               
               
                 7045000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:7277001- 
                 Otub1 
                 2.452 
                 1.023 
                 3.308 
                 4.754 
                 4.000 
                 −1.548 
               
               
                 7278000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:101519001- 
                 Traf6 
                 2.452 
                 4.345 
                 3.308 
                 3.754 
                 3.000 
                 −0.548 
               
               
                 101520000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:116727001- 
                 D330050G23Rik 
                 2.452 
                 4.023 
                 4.045 
                 3.754 
                 4.000 
                 −1.548 
               
               
                 116728000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:119097001- 
                 Rhov 
                 2.452 
                 3.023 
                 2.723 
                 4.017 
                 3.459 
                 −1.007 
               
               
                 119098000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:12846001- 
                 Pter 
                 1.867 
                 2.608 
                 3.308 
                 2.433 
                 3.907 
                 −2.040 
               
               
                 12847000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:130107001- 
                 Idh3b 
                 1.867 
                 2.608 
                 1.723 
                 4.017 
                 3.585 
                 −1.718 
               
               
                 130108000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:131030001- 
                 2310035K24Rik 
                 1.867 
                 4.023 
                 3.723 
                 1.433 
                 3.000 
                 −1.133 
               
               
                 131031000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:132697001- 
                 Lrrn4 
                 1.867 
                 3.831 
                 4.045 
                 3.433 
                 3.700 
                 −1.833 
               
               
                 132698000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:143764001- 
                 Dstn 
                 2.452 
                 4.193 
                 4.045 
                 3.433 
                 3.700 
                 −1.248 
               
               
                 143765000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:143808001- 
                 Rrbp1 
                 2.452 
                 4.023 
                 1.723 
                 4.433 
                 4.000 
                 −1.548 
               
               
                 143809000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:146002001- 
                 4930529M08Rik 
                 3.452 
                 4.023 
                 4.045 
                 4.754 
                 4.907 
                 −1.455 
               
               
                 146003000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:155074001- 
                 Dynlrb1 
                 3.189 
                 3.608 
                 1.571 
                 5.240 
                 4.248 
                 −1.059 
               
               
                 155075000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:155817001- 
                 Cep250 
                 1.867 
                 3.831 
                 4.308 
                 1.433 
                 3.807 
                 −1.940 
               
               
                 155818000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:160586001- 
                 Plcg1 
                 2.192 
                 4.608 
                 2.723 
                 4.240 
                 2.622 
                 −0.430 
               
               
                 160587000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:164667001- 
                 Pltp 
                 2.452 
                 4.193 
                 4.045 
                 3.017 
                 3.807 
                 −1.355 
               
               
                 164668000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:164719001- 
                 Pcif1 
                 2.452 
                 2.608 
                 4.045 
                 4.433 
                 3.585 
                 −1.133 
               
               
                 164720000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:173076001- 
                 Pmepa1 
                 2.452 
                 2.608 
                 4.308 
                 2.433 
                 3.459 
                 −1.007 
               
               
                 173077000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:174165001- 
                 Gnas 
                 1.867 
                 2.608 
                 3.308 
                 2.433 
                 3.000 
                 −1.133 
               
               
                 174166000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:174257001- 
                 Ctsz 
                 0.867 
                 4.023 
                 3.723 
                 3.754 
                 3.170 
                 −2.303 
               
               
                 174258000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:174287001- 
                 Atp5e 
                 1.867 
                 4.023 
                 3.723 
                 4.017 
                 3.807 
                 −1.940 
               
               
                 174288000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:176979001- 
                 Gm14410 
                 2.452 
                 2.023 
                 3.723 
                 3.754 
                 3.700 
                 −1.248 
               
               
                 176980000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:18923001- 
                 4930426L09Rik 
                 1.867 
                 3.831 
                 4.308 
                 4.433 
                 3.322 
                 −1.455 
               
               
                 18924000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:25053001- 
                 A830007P12Rik 
                 2.867 
                 3.608 
                 4.308 
                 3.433 
                 4.087 
                 −1.220 
               
               
                 25054000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:25097001- 
                 2310002J15Rik 
                 0.867 
                 3.608 
                 2.723 
                 3.433 
                 2.000 
                 −1.133 
               
               
                 25098000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:25129001- 
                 Anapc2 
                 0.867 
                 4.345 
                 2.723 
                 3.017 
                 4.000 
                 −3.133 
               
               
                 25130000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:25165001- 
                 Grin1 
                 3.452 
                 4.930 
                 4.893 
                 4.017 
                 4.459 
                 −1.007 
               
               
                 25166000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:25187001- 
                 AA543186 
                 1.867 
                 4.345 
                 3.308 
                 4.017 
                 3.170 
                 −1.303 
               
               
                 25188000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:25947001- 
                 Nacc2 
                 1.867 
                 4.023 
                 3.308 
                 2.433 
                 3.170 
                 −1.303 
               
               
                 25948000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:32181001- 
                 Dnm1 
                 2.452 
                 4.023 
                 3.308 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 32182000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:35899001- 
                 Ndufa8 
                 2.452 
                 4.023 
                 4.045 
                 3.017 
                 3.459 
                 −1.007 
               
               
                 35900000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:91098001- 
                 Pacsin3 
                 1.867 
                 4.193 
                 3.723 
                 2.433 
                 3.807 
                 −1.940 
               
               
                 91099000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:92233001- 
                 Mapk8ip1 
                 1.867 
                 3.023 
                 3.308 
                 4.017 
                 3.459 
                 −1.592 
               
               
                 92234000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:94231001- 
                 Ttc17 
                 1.867 
                 4.023 
                 1.723 
                 3.433 
                 4.644 
                 −2.777 
               
               
                 94232000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:117529001- 
                 Snx7 
                 2.867 
                 3.345 
                 3.308 
                 4.240 
                 4.248 
                 −1.381 
               
               
                 117530000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:127339001- 
                 Neurog2 
                 1.867 
                 3.831 
                 1.723 
                 3.433 
                 3.807 
                 −1.940 
               
               
                 127340000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:151119001- 
                 Eltd1 
                 3.452 
                 3.608 
                 4.531 
                 4.433 
                 4.524 
                 −1.072 
               
               
                 151120000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:151905001- 
                 Nexn 
                 2.867 
                 3.608 
                 4.308 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 151906000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:27894001- 
                 Pld1 
                 1.867 
                 2.023 
                 3.308 
                 2.433 
                 3.000 
                 −1.133 
               
               
                 27895000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:53251001- 
                 Nhlrc3 
                 0.715 
                 3.023 
                 2.723 
                 3.017 
                 3.000 
                 −2.285 
               
               
                 53252000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:63734001- 
                 E130311K13Rik 
                 1.867 
                 4.193 
                 2.723 
                 3.433 
                 3.170 
                 −1.303 
               
               
                 63735000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:68843001- 
                 Trim59 
                 1.867 
                 3.345 
                 3.308 
                 4.240 
                 3.322 
                 −1.455 
               
               
                 68844000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:101320001- 
                 Leprot 
                 1.867 
                 4.023 
                 2.723 
                 4.017 
                 3.000 
                 −1.133 
               
               
                 101321000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:107356001- 
                 Dmrtb1 
                 1.867 
                 3.345 
                 3.308 
                 2.433 
                 4.087 
                 −2.220 
               
               
                 107357000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:114588001- 
                 9130206I24Rik 
                 2.867 
                 3.023 
                 4.723 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 114589000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:116825001- 
                 Rps8 
                 2.867 
                 3.023 
                 3.308 
                 4.602 
                 4.000 
                 −1.133 
               
               
                 116826000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:118034001- 
                 Hyi 
                 1.867 
                 4.023 
                 3.308 
                 4.017 
                 3.000 
                 −1.133 
               
               
                 118035000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:122783001- 
                 Bmp8b 
                 1.867 
                 2.608 
                 3.723 
                 3.433 
                 3.000 
                 −1.133 
               
               
                 122784000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:123397001- 
                 Ndufs5 
                 2.452 
                 4.483 
                 4.308 
                 2.433 
                 3.807 
                 −1.355 
               
               
                 123398000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:123603001- 
                 Rragc 
                 1.867 
                 4.608 
                 2.723 
                 3.433 
                 3.459 
                 −1.592 
               
               
                 123604000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:125714001- 
                 Csf3r 
                 1.867 
                 3.608 
                 3.723 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 125715000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:125925001- 
                 Mtap7d1 
                 1.867 
                 4.345 
                 1.723 
                 4.017 
                 3.585 
                 −1.718 
               
               
                 125926000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:126178001- 
                 Eif2c4 
                 2.867 
                 3.345 
                 3.308 
                 4.433 
                 4.644 
                 −1.777 
               
               
                 126179000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:128628001- 
                 Adc 
                 2.452 
                 4.608 
                 2.723 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 128629000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:129054001- 
                 Zbtb8a 
                 0.867 
                 2.023 
                 1.723 
                 3.754 
                 3.459 
                 −2.592 
               
               
                 129055000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:130168001- 
                 Nkain1 
                 2.452 
                 3.345 
                 4.531 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 130169000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:132961001- 
                 Slc9a1 
                 1.867 
                 4.193 
                 2.723 
                 3.017 
                 3.700 
                 −1.833 
               
               
                 132962000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:134478001- 
                 D4Wsu53e 
                 0.867 
                 3.608 
                 3.308 
                 3.754 
                 4.000 
                 −3.133 
               
               
                 134479000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:135029001- 
                 Nipal3 
                 2.452 
                 4.345 
                 3.308 
                 4.017 
                 3.907 
                 −1.455 
               
               
                 135030000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:135522001- 
                 Gale 
                 0.867 
                 3.023 
                 3.723 
                 3.754 
                 3.322 
                 −2.455 
               
               
                 135523000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:137115001- 
                 Hspg2 
                 1.867 
                 3.608 
                 2.723 
                 3.017 
                 3.585 
                 −1.718 
               
               
                 137116000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:138875001- 
                 Akr7a5 
                 1.867 
                 3.023 
                 2.723 
                 3.017 
                 3.907 
                 −2.040 
               
               
                 138876000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:140239001- 
                 Gm13025 
                 1.867 
                 2.608 
                 1.723 
                 3.754 
                 3.807 
                 −1.940 
               
               
                 140240000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:143112001- 
                 Gm13040 
                 3.452 
                 3.831 
                 4.723 
                 4.433 
                 4.907 
                 −1.455 
               
               
                 143113000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:143135001- 
                 Gm13057 
                 3.452 
                 4.483 
                 4.531 
                 4.433 
                 4.907 
                 −1.455 
               
               
                 143136000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:147322001- 
                 2510039O18Rik 
                 2.452 
                 3.023 
                 4.893 
                 3.433 
                 3.807 
                 −1.355 
               
               
                 147323000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:147523001- 
                 Fbxo6 
                 2.452 
                 3.345 
                 4.531 
                 2.433 
                 3.585 
                 −1.133 
               
               
                 147524000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:147967001- 
                 Srm 
                 2.452 
                 4.345 
                 4.045 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 147968000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:151462001- 
                 Plekhg5 
                 1.867 
                 3.023 
                 3.308 
                 2.433 
                 3.170 
                 −1.303 
               
               
                 151463000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:15202001- 
                 Tmem64 
                 2.452 
                 4.345 
                 4.045 
                 3.017 
                 3.807 
                 −1.355 
               
               
                 15203000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:155237001- 
                 Tas1r3 
                 0.867 
                 3.023 
                 1.571 
                 3.754 
                 3.170 
                 −2.303 
               
               
                 155238000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:35172001- 
                 3110043O21Rik 
                 1.867 
                 3.023 
                 2.723 
                 3.433 
                 3.000 
                 −1.133 
               
               
                 35173000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:43055001- 
                 B230312A22Rik 
                 2.452 
                 3.831 
                 3.723 
                 3.754 
                 4.000 
                 −1.548 
               
               
                 43056000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:44994001- 
                 Grhpr 
                 1.867 
                 2.608 
                 2.723 
                 3.433 
                 3.807 
                 −1.940 
               
               
                 44995000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:45911001- 
                 E230008N13Rik 
                 2.452 
                 4.345 
                 3.308 
                 3.754 
                 3.700 
                 −1.248 
               
               
                 45912000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:48551001- 
                 5730528L13Rik 
                 2.452 
                 3.831 
                 4.045 
                 3.754 
                 4.087 
                 −1.635 
               
               
                 48552000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:61926001- 
                 Slc31a2 
                 1.867 
                 2.608 
                 2.723 
                 3.017 
                 3.459 
                 −1.592 
               
               
                 61927000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:101081001- 
                 Coq2 
                 2.452 
                 3.345 
                 3.308 
                 4.433 
                 3.459 
                 −1.007 
               
               
                 101082000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:108154001- 
                 Gfi1 
                 0.867 
                 3.831 
                 3.723 
                 3.754 
                 2.585 
                 −1.718 
               
               
                 108155000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:110119001- 
                 5430403G16Rik 
                 0.715 
                 3.831 
                 3.308 
                 4.240 
                 4.087 
                 −3.372 
               
               
                 110120000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:115891001- 
                 Msi1 
                 2.452 
                 2.608 
                 1.723 
                 4.240 
                 3.585 
                 −1.133 
               
               
                 115892000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:115963001- 
                 Pxn 
                 2.452 
                 3.831 
                 4.045 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 115964000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:122303001- 
                 Fam109a 
                 2.452 
                 2.608 
                 4.308 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 122304000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:122855001- 
                 Arpc3 
                 0.867 
                 4.483 
                 3.308 
                 4.017 
                 4.000 
                 −3.133 
               
               
                 122856000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:124312001- 
                 Niacr1 
                 2.452 
                 3.345 
                 3.308 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 124313000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:135725001- 
                 Fzd9 
                 1.867 
                 4.608 
                 3.308 
                 2.433 
                 3.170 
                 −1.303 
               
               
                 135726000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:136213001- 
                 Tmem120a 
                 1.867 
                 0.871 
                 4.308 
                 4.240 
                 4.000 
                 −2.133 
               
               
                 136214000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:136625001- 
                 Orai2 
                 1.867 
                 3.345 
                 2.723 
                 3.017 
                 3.000 
                 −1.133 
               
               
                 136626000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:137548001- 
                 Serpine1 
                 1.867 
                 3.023 
                 3.308 
                 2.433 
                 3.700 
                 −1.833 
               
               
                 137549000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:138637001- 
                 Mblac1 
                 1.867 
                 3.023 
                 4.308 
                 1.280 
                 3.000 
                 −1.133 
               
               
                 138638000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:141093001- 
                 Lfng 
                 1.867 
                 3.345 
                 1.723 
                 3.433 
                 3.585 
                 −1.718 
               
               
                 141094000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:141183001- 
                 Baat1 
                 2.452 
                 3.831 
                 4.531 
                 3.433 
                 3.585 
                 −1.133 
               
               
                 141184000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:144952001- 
                 Bhlha15 
                 1.867 
                 3.345 
                 3.723 
                 2.433 
                 3.170 
                 −1.303 
               
               
                 144953000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:23948001- 
                 Fastk 
                 2.452 
                 4.345 
                 4.045 
                 4.754 
                 3.459 
                 −1.007 
               
               
                 23949000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:31202001- 
                 Agbl5 
                 1.867 
                 3.608 
                 1.723 
                 3.433 
                 3.000 
                 −1.133 
               
               
                 31203000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:34978001- 
                 Mfsd10 
                 2.452 
                 2.608 
                 4.308 
                 3.433 
                 3.585 
                 −1.133 
               
               
                 34979000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:42472001- 
                 Gm16223 
                 1.867 
                 2.608 
                 2.723 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 42473000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:44227001- 
                 Bst1 
                 2.452 
                 4.023 
                 4.531 
                 4.017 
                 4.087 
                 −1.635 
               
               
                 44228000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:65875001- 
                 1110003E01Rik 
                 1.867 
                 3.345 
                 3.723 
                 1.433 
                 3.459 
                 −1.592 
               
               
                 65876000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:67820001- 
                 Gm16714 
                 2.867 
                 3.831 
                 4.531 
                 3.433 
                 3.907 
                 −1.040 
               
               
                 67821000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:68240001- 
                 Gm15477 
                 2.452 
                 4.023 
                 4.045 
                 3.017 
                 3.807 
                 −1.355 
               
               
                 68241000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:96991001- 
                 Fras1 
                 3.867 
                 4.193 
                 5.424 
                 4.240 
                 5.358 
                 −1.491 
               
               
                 96992000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:97537001- 
                 Paqr3 
                 0.867 
                 3.345 
                 4.045 
                 4.240 
                 2.807 
                 −1.940 
               
               
                 97538000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:113236001- 
                 Cpne9 
                 2.452 
                 4.023 
                 3.723 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 113237000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:113289001- 
                 Camk1 
                 0.867 
                 3.345 
                 1.723 
                 4.017 
                 3.585 
                 −2.718 
               
               
                 113290000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:113340001- 
                 Arpc4 
                 2.867 
                 3.023 
                 2.723 
                 4.602 
                 4.000 
                 −1.133 
               
               
                 113341000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:121216001- 
                 Usp18 
                 2.452 
                 3.345 
                 2.723 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 121217000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:124344001- 
                 Pex5 
                 2.452 
                 3.608 
                 3.308 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 124345000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:124715001- 
                 Eno2 
                 2.452 
                 4.023 
                 3.308 
                 3.754 
                 3.585 
                 −1.133 
               
               
                 124716000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:125095001- 
                 Iffo1 
                 1.867 
                 3.023 
                 3.308 
                 2.433 
                 3.322 
                 −1.455 
               
               
                 125096000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:126802001- 
                 Akap3 
                 2.867 
                 4.023 
                 3.723 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 126803000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:129453001- 
                 Olr1 
                 2.867 
                 4.345 
                 4.308 
                 4.240 
                 4.087 
                 −1.220 
               
               
                 129454000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:29356001- 
                 Ccdc136 
                 2.867 
                 4.023 
                 3.308 
                 4.240 
                 4.087 
                 −1.220 
               
               
                 29357000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:36799001- 
                 Dgki 
                 1.867 
                 4.193 
                 4.045 
                 1.280 
                 3.322 
                 −1.455 
               
               
                 36800000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:47804001- 
                 Zfp398 
                 3.189 
                 4.193 
                 4.308 
                 4.240 
                 4.700 
                 −1.511 
               
               
                 47805000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:48359001- 
                 Krba1 
                 2.867 
                 3.831 
                 4.308 
                 3.433 
                 3.907 
                 −1.040 
               
               
                 48360000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:48546001- 
                 Repin1 
                 1.867 
                 4.345 
                 2.723 
                 3.433 
                 3.700 
                 −1.833 
               
               
                 48547000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:54640001- 
                 2410066E13Rik 
                 1.867 
                 3.831 
                 2.723 
                 3.017 
                 3.459 
                 −1.592 
               
               
                 54641000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:83090001- 
                 Rtkn 
                 1.867 
                 3.608 
                 1.571 
                 4.017 
                 3.170 
                 −1.303 
               
               
                 83091000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:83104001- 
                 Wdr54 
                 1.867 
                 3.831 
                 4.045 
                 3.017 
                 3.700 
                 −1.833 
               
               
                 83105000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:85077001- 
                 Gm5878 
                 2.452 
                 3.608 
                 4.045 
                 3.433 
                 3.459 
                 −1.007 
               
               
                 85078000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:88860001- 
                 Tpra1 
                 2.452 
                 2.023 
                 4.308 
                 3.017 
                 3.459 
                 −1.007 
               
               
                 88861000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:89273001- 
                 Gm16896 
                 2.452 
                 3.608 
                 1.571 
                 4.433 
                 3.700 
                 −1.248 
               
               
                 89274000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:97766001- 
                 Mitf 
                 2.867 
                 3.023 
                 4.308 
                 3.433 
                 4.392 
                 −1.525 
               
               
                 97767000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:105333001- 
                 Gm16938 
                 2.867 
                 3.345 
                 3.723 
                 4.017 
                 4.087 
                 −1.220 
               
               
                 105334000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:105511001- 
                 Tsku 
                 2.867 
                 3.831 
                 3.308 
                 4.433 
                 4.000 
                 −1.133 
               
               
                 105512000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:107648001- 
                 Ucp2 
                 0.867 
                 3.831 
                 3.723 
                 4.240 
                 3.322 
                 −2.455 
               
               
                 107649000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:107660001- 
                 Dnajb13 
                 2.867 
                 4.023 
                 4.045 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 107661000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:109361001- 
                 Pgap2 
                 1.867 
                 2.023 
                 3.723 
                 5.017 
                 3.807 
                 −1.940 
               
               
                 109362000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:111538001- 
                 Trim30c 
                 3.189 
                 4.193 
                 4.531 
                 4.240 
                 4.248 
                 −1.059 
               
               
                 111539000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:130607001- 
                 Aqp8 
                 2.867 
                 3.345 
                 3.308 
                 4.433 
                 4.000 
                 −1.133 
               
               
                 130608000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:13082001- 
                 Zfp606 
                 1.867 
                 4.023 
                 4.045 
                 3.017 
                 3.459 
                 −1.592 
               
               
                 13083000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:133942001- 
                 Aldoa 
                 1.867 
                 3.345 
                 2.723 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 133943000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:134350001- 
                 Tbc1d10b 
                 1.867 
                 4.345 
                 1.723 
                 3.433 
                 3.459 
                 −1.592 
               
               
                 134351000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:134358001- 
                 SEPT_1 
                 0.715 
                 4.345 
                 2.723 
                 3.017 
                 3.000 
                 −2.285 
               
               
                 134359000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:134635001- 
                 Fbrs 
                 0.867 
                 3.023 
                 3.308 
                 3.017 
                 3.907 
                 −3.040 
               
               
                 134636000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:134978001- 
                 Stx4a 
                 2.452 
                 3.608 
                 4.045 
                 3.433 
                 3.807 
                 −1.355 
               
               
                 134979000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:135242001- 
                 Itgam 
                 2.867 
                 3.023 
                 3.723 
                 4.017 
                 4.000 
                 −1.133 
               
               
                 135243000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:148050001- 
                 Sirt3 
                 0.867 
                 3.608 
                 3.723 
                 3.754 
                 3.700 
                 −2.833 
               
               
                 148051000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:148396001- 
                 1600016N20Rik 
                 1.867 
                 1.023 
                 4.893 
                 3.433 
                 3.000 
                 −1.133 
               
               
                 148397000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:148672001- 
                 Tspan4 
                 0.867 
                 4.345 
                 4.308 
                 3.754 
                 3.585 
                 −2.718 
               
               
                 148673000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:149244001- 
                 Mob2 
                 1.867 
                 3.608 
                 1.723 
                 3.433 
                 3.170 
                 −1.303 
               
               
                 149245000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:150970001- 
                 Mrgpre 
                 1.867 
                 3.831 
                 1.723 
                 4.017 
                 4.000 
                 −2.133 
               
               
                 150971000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:17478001- 
                 Gng8 
                 0.867 
                 3.345 
                 3.308 
                 3.017 
                 3.459 
                 −2.592 
               
               
                 17479000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:19713001- 
                 Fbxo46 
                 2.867 
                 3.831 
                 3.308 
                 4.240 
                 3.907 
                 −1.040 
               
               
                 19714000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:19799001- 
                 Gpr4 
                 2.452 
                 3.345 
                 2.723 
                 4.602 
                 3.585 
                 −1.133 
               
               
                 19800000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:20229001- 
                 Clptm1 
                 2.452 
                 3.023 
                 4.045 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 20230000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:20320001- 
                 Pvrl2 
                 2.452 
                 4.193 
                 4.045 
                 3.433 
                 3.459 
                 −1.007 
               
               
                 20321000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:20352001- 
                 Bcam 
                 2.452 
                 4.193 
                 4.045 
                 4.602 
                 3.700 
                 −1.248 
               
               
                 20353000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:25169001- 
                 Kcnn4 
                 1.867 
                 2.023 
                 3.308 
                 4.017 
                 3.322 
                 −1.455 
               
               
                 25170000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:28453001- 
                 Map3k10 
                 0.867 
                 3.608 
                 3.723 
                 4.017 
                 2.807 
                 −1.940 
               
               
                 28454000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:29137001- 
                 Rps16 
                 2.867 
                 2.608 
                 4.045 
                 3.754 
                 4.000 
                 −1.133 
               
               
                 29138000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:29174001- 
                 Med29 
                 1.867 
                 3.345 
                 4.531 
                 3.017 
                 3.700 
                 −1.833 
               
               
                 29175000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:29329001- 
                 Nccrp1 
                 2.452 
                 3.023 
                 3.308 
                 3.754 
                 3.585 
                 −1.133 
               
               
                 29330000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:29513001- 
                 Fbxo17 
                 2.867 
                 3.831 
                 3.723 
                 4.602 
                 4.000 
                 −1.133 
               
               
                 29514000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:29669001- 
                 Capn12 
                 2.867 
                 3.023 
                 4.723 
                 3.433 
                 4.170 
                 −1.303 
               
               
                 29670000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:30555001- 
                 Zfp84 
                 2.452 
                 3.831 
                 4.045 
                 3.017 
                 4.000 
                 −1.548 
               
               
                 30556000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:30602001- 
                 Zfp790 
                 2.867 
                 3.345 
                 4.531 
                 3.433 
                 4.322 
                 −1.455 
               
               
                 30603000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:3112001- 
                 Gm7353 
                 2.867 
                 3.831 
                 4.308 
                 4.017 
                 4.170 
                 −1.303 
               
               
                 3113000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:31241001- 
                 Kirrel2 
                 2.452 
                 3.345 
                 3.723 
                 3.754 
                 3.907 
                 −1.455 
               
               
                 31242000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:3624001- 
                 Tmc4 
                 2.452 
                 3.345 
                 3.308 
                 4.017 
                 3.807 
                 −1.355 
               
               
                 3625000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:3758001- 
                 Pira5 
                 3.452 
                 4.483 
                 5.183 
                 3.433 
                 4.907 
                 −1.455 
               
               
                 3759000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:3866001- 
                 Lilra6 
                 1.867 
                 4.345 
                 2.723 
                 3.017 
                 3.585 
                 −1.718 
               
               
                 3867000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:4651001- 
                 Brsk1 
                 2.867 
                 3.608 
                 4.045 
                 3.754 
                 4.248 
                 −1.381 
               
               
                 4652000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:50743001- 
                 Iglon5 
                 2.452 
                 3.023 
                 4.045 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 50744000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:51917001- 
                 Myh14 
                 2.452 
                 4.193 
                 3.723 
                 3.433 
                 4.087 
                 −1.635 
               
               
                 51918000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:52113001- 
                 Pnkp 
                 1.867 
                 3.608 
                 3.723 
                 3.433 
                 3.585 
                 −1.718 
               
               
                 52114000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:52122001- 
                 Ptov1 
                 0.867 
                 1.023 
                 1.723 
                 2.433 
                 2.585 
                 −1.718 
               
               
                 52123000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:52258001- 
                 Irf3 
                 1.867 
                 3.023 
                 4.045 
                 1.433 
                 3.170 
                 −1.303 
               
               
                 52259000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:52408001- 
                 Aldh16a1 
                 2.452 
                 3.023 
                 3.308 
                 3.754 
                 3.907 
                 −1.455 
               
               
                 52409000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:52901001- 
                 Mamstr 
                 2.452 
                 4.345 
                 4.045 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 52902000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:53113001- 
                 Grin2d 
                 2.452 
                 3.023 
                 3.308 
                 3.754 
                 3.807 
                 −1.355 
               
               
                 53114000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:53971001- 
                 Saa3 
                 2.452 
                 4.193 
                 3.308 
                 4.433 
                 3.907 
                 −1.455 
               
               
                 53972000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:69619001- 
                 Atp5l-ps1 
                 3.452 
                 2.608 
                 4.893 
                 4.433 
                 4.807 
                 −1.355 
               
               
                 69620000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:86857001- 
                 Kif7 
                 2.452 
                 3.345 
                 4.308 
                 3.017 
                 3.585 
                 −1.133 
               
               
                 86858000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:86958001- 
                 Mesp2 
                 2.452 
                 3.831 
                 4.045 
                 4.017 
                 3.807 
                 −1.355 
               
               
                 86959000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:87188001- 
                 Zfp710 
                 1.867 
                 3.345 
                 2.723 
                 3.017 
                 3.700 
                 −1.833 
               
               
                 87189000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:87333001- 
                 Sema4b 
                 2.867 
                 4.023 
                 3.723 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 87334000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:87472001- 
                 Unc45a 
                 1.867 
                 3.345 
                 3.308 
                 2.433 
                 3.322 
                 −1.455 
               
               
                 87473000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:95676001- 
                 Gm10159 
                 2.452 
                 3.608 
                 3.308 
                 3.754 
                 4.170 
                 −1.718 
               
               
                 95677000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:107870001- 
                 Fhod1 
                 0.867 
                 3.023 
                 3.723 
                 3.754 
                 3.700 
                 −2.833 
               
               
                 107871000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:107879001- 
                 Slc9a5 
                 1.867 
                 4.724 
                 1.723 
                 3.433 
                 3.459 
                 −1.592 
               
               
                 107880000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:108050001- 
                 Atp6v0d1 
                 1.867 
                 3.608 
                 3.308 
                 2.433 
                 3.170 
                 −1.303 
               
               
                 108051000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:108380001- 
                 Thap11 
                 2.452 
                 3.345 
                 4.308 
                 3.754 
                 3.585 
                 −1.133 
               
               
                 108381000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:108469001- 
                 Gm16156 
                 2.452 
                 3.831 
                 3.723 
                 4.240 
                 3.700 
                 −1.248 
               
               
                 108470000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:114259001- 
                 Bcar1 
                 1.867 
                 3.023 
                 2.723 
                 3.017 
                 4.322 
                 −2.455 
               
               
                 114260000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:114397001- 
                 Tmem170 
                 0.867 
                 3.608 
                 3.723 
                 3.017 
                 3.700 
                 −2.833 
               
               
                 114398000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:15026001- 
                 Kbtbd11 
                 2.452 
                 2.023 
                 2.723 
                 4.017 
                 3.585 
                 −1.133 
               
               
                 15027000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:26202001- 
                 Plekha2 
                 1.867 
                 3.345 
                 1.723 
                 3.433 
                 3.322 
                 −1.455 
               
               
                 26203000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:28086001- 
                 Zfp703 
                 2.867 
                 3.023 
                 3.723 
                 4.017 
                 4.170 
                 −1.303 
               
               
                 28087000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:28137001- 
                 Erlin2 
                 2.452 
                 2.608 
                 2.723 
                 4.240 
                 3.807 
                 −1.355 
               
               
                 28138000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:37088001- 
                 Gm10063 
                 0.867 
                 4.608 
                 1.723 
                 2.433 
                 3.170 
                 −2.303 
               
               
                 37089000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:4135001- 
                 Cd209g 
                 2.452 
                 3.608 
                 3.308 
                 3.754 
                 3.459 
                 −1.007 
               
               
                 4136000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:4245001- 
                 Map2k7 
                 0.867 
                 3.608 
                 3.308 
                 1.280 
                 2.585 
                 −1.718 
               
               
                 4246000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:4681001- 
                 Gm6410 
                 3.189 
                 4.023 
                 4.531 
                 4.017 
                 4.248 
                 −1.059 
               
               
                 4682000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:48763001- 
                 AA386476 
                 2.452 
                 3.608 
                 2.723 
                 4.433 
                 3.459 
                 −1.007 
               
               
                 48764000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:72447001- 
                 Gatad2a 
                 1.867 
                 4.193 
                 2.723 
                 3.017 
                 3.700 
                 −1.833 
               
               
                 72448000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:72822001- 
                 Ddx49 
                 1.867 
                 4.345 
                 3.308 
                 2.433 
                 3.585 
                 −1.718 
               
               
                 72823000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:73039001- 
                 2810422J05Rik 
                 2.867 
                 3.608 
                 3.723 
                 4.240 
                 4.000 
                 −1.133 
               
               
                 73040000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:73140001- 
                 Lrrc25 
                 1.867 
                 4.724 
                 2.723 
                 3.433 
                 3.000 
                 −1.133 
               
               
                 73141000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:73198001- 
                 Lsm4 
                 2.452 
                 0.871 
                 3.723 
                 4.602 
                 3.907 
                 −1.455 
               
               
                 73199000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:73257001- 
                 Pde4c 
                 1.867 
                 3.608 
                 2.723 
                 3.017 
                 3.000 
                 −1.133 
               
               
                 73258000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:73408001- 
                 Slc5a5 
                 1.867 
                 4.193 
                 3.723 
                 1.433 
                 3.907 
                 −2.040 
               
               
                 73409000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:73789001- 
                 Haus8 
                 1.867 
                 3.345 
                 2.723 
                 3.017 
                 4.000 
                 −2.133 
               
               
                 73790000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:74087001- 
                 Nxnl1 
                 2.867 
                 3.023 
                 3.723 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 74088000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:74114001- 
                 Pgls 
                 2.452 
                 4.023 
                 4.045 
                 3.017 
                 3.807 
                 −1.355 
               
               
                 74115000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:85688001- 
                 Gm10645 
                 2.452 
                 3.023 
                 3.308 
                 3.754 
                 3.907 
                 −1.455 
               
               
                 85689000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:86649001- 
                 Podnl1 
                 1.867 
                 3.023 
                 2.723 
                 3.017 
                 3.170 
                 −1.303 
               
               
                 86650000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:87542001- 
                 Asna1 
                 2.452 
                 4.193 
                 3.308 
                 3.754 
                 3.700 
                 −1.248 
               
               
                 87543000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:98339001- 
                 4930513N10Rik 
                 1.867 
                 4.023 
                 2.723 
                 4.240 
                 3.700 
                 −1.833 
               
               
                 98340000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:106346001- 
                 Abhd14a 
                 2.452 
                 2.608 
                 4.308 
                 2.433 
                 3.459 
                 −1.007 
               
               
                 106347000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:107444001- 
                 Cyb561d2 
                 1.867 
                 2.608 
                 2.723 
                 3.433 
                 3.700 
                 −1.833 
               
               
                 107445000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:107476001- 
                 Hyal2 
                 1.867 
                 4.345 
                 1.723 
                 3.754 
                 3.700 
                 −1.833 
               
               
                 107477000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:114277001- 
                 4930520O04Rik 
                 0.867 
                 3.023 
                 2.723 
                 3.433 
                 3.000 
                 −2.133 
               
               
                 114278000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:114399001- 
                 Ccr4 
                 2.452 
                 3.608 
                 4.045 
                 3.433 
                 4.000 
                 −1.548 
               
               
                 114400000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:119392001- 
                 Scn5a 
                 2.867 
                 3.831 
                 3.723 
                 4.017 
                 4.000 
                 −1.133 
               
               
                 119393000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:120484001- 
                 Rpl14 
                 2.867 
                 4.023 
                 4.531 
                 3.754 
                 4.322 
                 −1.455 
               
               
                 120485000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:122933001- 
                 Tmem42 
                 2.452 
                 4.345 
                 3.723 
                 3.433 
                 3.700 
                 −1.248 
               
               
                 122934000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:15393001- 
                 Ccdc67 
                 2.452 
                 4.193 
                 2.723 
                 4.017 
                 3.700 
                 −1.248 
               
               
                 15394000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:20453001- 
                 Ubl5 
                 2.452 
                 3.608 
                 1.723 
                 5.017 
                 4.392 
                 −1.940 
               
               
                 20454000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:20876001- 
                 Fdx1l 
                 0.867 
                 2.023 
                 3.723 
                 3.754 
                 3.459 
                 −2.592 
               
               
                 20877000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:21150001- 
                 Slc44a2 
                 2.867 
                 4.608 
                 4.045 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 21151000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:21932001- 
                 Acp5 
                 2.867 
                 2.608 
                 4.308 
                 3.433 
                 3.459 
                 −0.592 
               
               
                 21933000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:22087001- 
                 Zfp810 
                 2.867 
                 3.608 
                 2.723 
                 4.754 
                 4.170 
                 −1.303 
               
               
                 22088000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:24933001- 
                 Herpud2 
                 2.452 
                 3.023 
                 2.723 
                 4.017 
                 4.322 
                 −1.870 
               
               
                 24934000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:35236001- 
                 Cdon 
                 2.867 
                 4.345 
                 4.045 
                 3.754 
                 3.907 
                 −1.040 
               
               
                 35237000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:42062001- 
                 Sc5d 
                 2.867 
                 3.831 
                 4.308 
                 4.017 
                 3.907 
                 −1.040 
               
               
                 42063000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:44577001- 
                 Ift46 
                 2.452 
                 3.023 
                 4.045 
                 3.017 
                 4.087 
                 −1.635 
               
               
                 44578000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:46078001- 
                 Apoa5 
                 1.867 
                 4.023 
                 2.723 
                 3.433 
                 3.000 
                 −1.133 
               
               
                 46079000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:50573001- 
                 1110032A03Rik 
                 0.867 
                 4.193 
                 1.723 
                 4.602 
                 3.322 
                 −2.455 
               
               
                 50574000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:55205001- 
                 AI118078 
                 2.452 
                 4.193 
                 4.308 
                 2.433 
                 3.907 
                 −1.455 
               
               
                 55206000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:57001001- 
                 Commd4 
                 2.867 
                 3.023 
                 4.045 
                 4.433 
                 4.000 
                 −1.133 
               
               
                 57002000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:57109001- 
                 1700017B05Rik 
                 1.867 
                 1.023 
                 1.571 
                 3.754 
                 3.000 
                 −1.133 
               
               
                 57110000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:59453001- 
                 Celf6 
                 1.867 
                 4.483 
                 2.723 
                 4.017 
                 3.807 
                 −1.940 
               
               
                 59454000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:59506001- 
                 Pkm2 
                 2.452 
                 3.831 
                 1.723 
                 4.240 
                 3.585 
                 −1.133 
               
               
                 59507000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:62715001- 
                 Gm10653 
                 1.867 
                 4.345 
                 1.723 
                 3.433 
                 4.585 
                 −2.718 
               
               
                 62716000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:65061001- 
                 Parp16 
                 2.452 
                 4.023 
                 4.045 
                 3.433 
                 3.700 
                 −1.248 
               
               
                 65062000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:66648001- 
                 BC050972 
                 1.867 
                 4.193 
                 2.723 
                 3.433 
                 3.700 
                 −1.833 
               
               
                 66649000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:70507001- 
                 Gm10642 
                 2.867 
                 4.193 
                 1.723 
                 4.602 
                 4.524 
                 −1.657 
               
               
                 70508000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:78092001- 
                 Dppa5b 
                 1.867 
                 3.831 
                 3.723 
                 3.754 
                 3.000 
                 −1.133 
               
               
                 78093000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:7838001- 
                 C330006D17Rik 
                 1.867 
                 3.345 
                 3.723 
                 3.017 
                 3.585 
                 −1.718 
               
               
                 7839000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:81538001- 
                 D430036J16Rik 
                 2.452 
                 5.111 
                 3.723 
                 4.433 
                 4.087 
                 −1.635 
               
               
                 81539000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:86462001- 
                 Pgm3 
                 1.867 
                 4.483 
                 3.308 
                 2.433 
                 3.459 
                 −1.592 
               
               
                 86463000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 ChrX:12195001- 
                 Atp6ap2 
                 1.867 
                 1.023 
                 4.045 
                 1.433 
                 3.000 
                 −1.133 
               
               
                 12196000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 ChrX:15513001- 
                 Drr1 
                 2.452 
                 3.608 
                 4.045 
                 4.240 
                 4.700 
                 −2.248 
               
               
                 15514000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 ChrX:34911001- 
                 Rhox2d 
                 0.867 
                 1.023 
                 3.308 
                 3.017 
                 3.459 
                 −2.592 
               
               
                 34912000 
                   
                   
                   
                   
                   
                   
                   
               
            
           
           
               
            
               
                 Cleavage in any region and don&#39;t show differential expression 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Chr1:146619001- 
                 Rgs18 
                 4.189 
                 2.608 
                 1.723 
                 1.433 
                 2.585 
                 1.604 
               
               
                 146620000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:159290001- 
                 Rasal2 
                 2.867 
                 1.023 
                 1.571 
                 2.433 
                 3.000 
                 −0.133 
               
               
                 159291000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:166005001- 
                 Sell 
                 5.115 
                 3.023 
                 3.308 
                 1.433 
                 4.524 
                 0.591 
               
               
                 166006000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:196548001- 
                 Plxna2 
                 4.954 
                 3.345 
                 2.723 
                 1.433 
                 3.459 
                 1.495 
               
               
                 196549000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:37087001- 
                 Vwa3b 
                 5.259 
                 2.023 
                 3.308 
                 2.433 
                 3.807 
                 1.452 
               
               
                 37088000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:44709001- 
                 Gulp1 
                 5.037 
                 1.023 
                 3.308 
                 3.433 
                 3.807 
                 1.230 
               
               
                 44710000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:60466001- 
                 Abi2 
                 4.037 
                 3.023 
                 1.571 
                 1.280 
                 2.000 
                 2.037 
               
               
                 60467000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:65410001- 
                 Pth2r 
                 4.189 
                 2.023 
                 1.571 
                 3.017 
                 3.585 
                 0.604 
               
               
                 65411000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr1:70884001- 
                 Vwc2l 
                 4.452 
                 0.871 
                 3.723 
                 2.433 
                 3.000 
                 1.452 
               
               
                 70885000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr10:13276001- 
                 Adat2 
                 4.189 
                 1.023 
                 1.571 
                 3.017 
                 3.459 
                 0.730 
               
               
                 13277000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:58088001- 
                 4930438A08Rik 
                 4.674 
                 1.023 
                 3.723 
                 2.433 
                 3.000 
                 1.674 
               
               
                 58089000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:67609001- 
                 Dhrs7c 
                 4.954 
                 3.023 
                 1.723 
                 3.433 
                 3.459 
                 1.495 
               
               
                 67610000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr11:97066001- 
                 Npepps 
                 0.867 
                 0.871 
                 1.571 
                 1.280 
                 1.585 
                 −0.718 
               
               
                 97067000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:114952001- 
                 Gm16594 
                 4.452 
                 1.023 
                 1.571 
                 1.433 
                 3.322 
                 1.130 
               
               
                 114953000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:67657001- 
                 Mdga2 
                 4.189 
                 0.871 
                 3.308 
                 2.433 
                 3.807 
                 0.382 
               
               
                 67658000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:76023001- 
                 Kcnh5 
                 4.452 
                 2.608 
                 1.723 
                 1.280 
                 3.170 
                 1.282 
               
               
                 76024000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:85792001- 
                 Lin52 
                 4.326 
                 2.023 
                 1.571 
                 2.433 
                 3.807 
                 0.519 
               
               
                 85793000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr12:88997001- 
                 BB287469 
                 0.715 
                 0.871 
                 1.571 
                 1.280 
                 −0.152 
                 0.867 
               
               
                 88998000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:105254001- 
                 Adamts6 
                 3.089 
                 2.023 
                 1.571 
                 1.280 
                 3.585 
                 −0.496 
               
               
                 105255000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:27941001- 
                 Prl2c1 
                 4.674 
                 3.023 
                 2.723 
                 1.280 
                 3.000 
                 1.674 
               
               
                 27942000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:39952001- 
                 U1 
                 4.452 
                 2.023 
                 2.723 
                 2.433 
                 3.322 
                 1.130 
               
               
                 39953000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:62252001- 
                 Zfp808 
                 4.037 
                 1.023 
                 1.723 
                 1.433 
                 3.807 
                 0.230 
               
               
                 62253000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:63532001- 
                 Fancc 
                 3.189 
                 2.023 
                 1.723 
                 1.280 
                 1.585 
                 1.604 
               
               
                 63533000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:63963001- 
                 0610007P08Rik 
                 3.867 
                 2.023 
                 1.723 
                 1.433 
                 1.585 
                 2.282 
               
               
                 63964000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr13:67199001- 
                 Zfp708 
                 4.774 
                 2.023 
                 3.723 
                 1.280 
                 3.585 
                 1.189 
               
               
                 67200000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:17610001- 
                 Rarb 
                 3.067 
                 2.608 
                 1.723 
                 1.280 
                 3.700 
                 −0.633 
               
               
                 17611000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:19507001- 
                 Ube2e2 
                 3.867 
                 1.023 
                 1.571 
                 3.017 
                 2.322 
                 1.545 
               
               
                 19508000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:63628001- 
                 Defb43 
                 4.567 
                 2.608 
                 3.308 
                 1.280 
                 3.000 
                 1.567 
               
               
                 63629000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr14:79733001- 
                 Naa16 
                 4.037 
                 2.608 
                 1.723 
                 1.280 
                 3.807 
                 0.230 
               
               
                 79734000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:54105001- 
                 Tnfrsf11b 
                 4.674 
                 2.608 
                 3.723 
                 1.280 
                 2.585 
                 2.089 
               
               
                 54106000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:7207001- 
                 Egflam 
                 4.954 
                 2.023 
                 3.723 
                 3.017 
                 3.700 
                 1.254 
               
               
                 7208000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr15:91341001- 
                 Slc2a13 
                 4.567 
                 2.023 
                 1.723 
                 2.433 
                 3.322 
                 1.246 
               
               
                 91342000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:50529001- 
                 G730013B05Rik 
                 4.189 
                 2.023 
                 2.723 
                 1.433 
                 2.585 
                 1.604 
               
               
                 50530000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr16:96367001- 
                 Wrb 
                 4.037 
                 2.023 
                 1.723 
                 2.433 
                 4.087 
                 −0.051 
               
               
                 96368000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:35480001- 
                 H2-Q2 
                 2.452 
                 1.023 
                 1.571 
                 1.433 
                 1.585 
                 0.867 
               
               
                 35481000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr17:52907001- 
                 Kcnh8 
                 3.867 
                 2.023 
                 2.723 
                 1.433 
                 2.585 
                 1.282 
               
               
                 52908000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:29999001- 
                 Il33 
                 4.326 
                 2.608 
                 1.723 
                 1.433 
                 3.807 
                 0.519 
               
               
                 30000000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr19:30250001- 
                 Gldc 
                 4.567 
                 2.023 
                 3.723 
                 1.280 
                 3.000 
                 1.567 
               
               
                 30251000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:103271001- 
                 Elf5 
                 4.189 
                 2.023 
                 1.571 
                 2.433 
                 3.700 
                 0.489 
               
               
                 103272000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:147699001- 
                 U6 
                 4.037 
                 1.023 
                 1.571 
                 2.433 
                 2.322 
                 1.715 
               
               
                 147700000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:17445001- 
                 Nebl 
                 4.326 
                 3.023 
                 1.571 
                 1.433 
                 3.459 
                 0.867 
               
               
                 17446000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:178164001- 
                 Cdh26 
                 3.674 
                 2.023 
                 1.723 
                 1.433 
                 2.000 
                 1.674 
               
               
                 178165000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:3631001- 
                 Fam107b 
                 4.189 
                 2.023 
                 1.571 
                 3.017 
                 2.322 
                 1.867 
               
               
                 3632000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:36667001- 
                 Olfr3 
                 4.567 
                 2.608 
                 2.723 
                 1.433 
                 0.000 
                 4.567 
               
               
                 36668000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:5182001- 
                 U2 
                 4.037 
                 2.608 
                 1.571 
                 1.280 
                 2.585 
                 1.452 
               
               
                 5183000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:52189001- 
                 Neb 
                 4.867 
                 1.023 
                 2.723 
                 3.017 
                 3.700 
                 1.167 
               
               
                 52190000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:6159001- 
                 A230108P19Rik 
                 4.326 
                 1.023 
                 1.723 
                 3.017 
                 3.807 
                 0.519 
               
               
                 6160000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr2:82806001- 
                 Fsip2 
                 4.452 
                 1.023 
                 1.723 
                 3.017 
                 3.459 
                 0.993 
               
               
                 82807000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:101408001- 
                 Atp1a1 
                 4.452 
                 3.023 
                 1.571 
                 2.433 
                 3.322 
                 1.130 
               
               
                 101409000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:105490001- 
                 Ddx20 
                 3.452 
                 1.023 
                 1.723 
                 1.280 
                 4.392 
                 −0.940 
               
               
                 105491000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:122843001- 
                 Synpo2 
                 4.774 
                 3.023 
                 1.571 
                 2.433 
                 3.907 
                 0.867 
               
               
                 122844000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:19231001- 
                 7SK 
                 3.189 
                 1.023 
                 1.571 
                 2.433 
                 2.585 
                 0.604 
               
               
                 19232000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:33290001- 
                 SNORA48 
                 4.452 
                 2.023 
                 2.723 
                 2.433 
                 2.322 
                 2.130 
               
               
                 33291000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:39700001- 
                 SNORA17 
                 3.452 
                 0.871 
                 1.723 
                 1.433 
                 3.000 
                 0.452 
               
               
                 39701000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:80921001- 
                 Pdgfc 
                 3.674 
                 1.023 
                 1.571 
                 2.433 
                 2.322 
                 1.352 
               
               
                 80922000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:83959001- 
                 Mnd1 
                 1.867 
                 1.023 
                 1.571 
                 1.433 
                 2.585 
                 −0.718 
               
               
                 83960000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr3:85157001- 
                 Arfip1 
                 4.567 
                 0.871 
                 3.308 
                 3.433 
                 4.170 
                 0.398 
               
               
                 85158000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:109321001- 
                 Gm12811 
                 4.326 
                 2.023 
                 2.723 
                 2.433 
                 3.807 
                 0.519 
               
               
                 109322000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:134319001- 
                 Ldlrap1 
                 4.954 
                 2.023 
                 2.723 
                 2.433 
                 3.585 
                 1.370 
               
               
                 134320000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:19331001- 
                 Cngb3 
                 4.452 
                 3.345 
                 1.723 
                 1.433 
                 2.807 
                 1.645 
               
               
                 19332000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:3943001- 
                 Sdr16c5 
                 4.452 
                 2.023 
                 2.723 
                 2.433 
                 3.459 
                 0.993 
               
               
                 3944000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:59130001- 
                 AI481877 
                 4.867 
                 3.023 
                 3.308 
                 1.280 
                 3.700 
                 1.167 
               
               
                 59131000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:61060001- 
                 Mup15 
                 3.867 
                 2.023 
                 1.723 
                 1.280 
                 3.322 
                 0.545 
               
               
                 61061000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr4:95349001- 
                 Fggy 
                 5.259 
                 3.023 
                 3.308 
                 3.017 
                 3.700 
                 1.559 
               
               
                 95350000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:127787001- 
                 Tmem132c 
                 3.867 
                 2.023 
                 1.571 
                 1.433 
                 3.170 
                 0.697 
               
               
                 127788000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:143871001- 
                 Rnf216 
                 3.867 
                 1.023 
                 1.571 
                 3.017 
                 3.000 
                 0.867 
               
               
                 143872000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:3397001- 
                 Cdk6 
                 4.867 
                 3.023 
                 2.723 
                 2.433 
                 3.000 
                 1.867 
               
               
                 3398000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:96390001- 
                 Cxcl13 
                 4.567 
                 1.023 
                 3.308 
                 3.017 
                 3.000 
                 1.567 
               
               
                 96391000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr5:9704001- 
                 Grm3 
                 3.452 
                 2.023 
                 1.723 
                 1.280 
                 3.170 
                 0.282 
               
               
                 9705000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:67321001- 
                 Il12rb2 
                 4.452 
                 2.023 
                 2.723 
                 2.433 
                 3.322 
                 1.130 
               
               
                 67322000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr6:87777001- 
                 Isy1 
                 4.452 
                 1.023 
                 3.308 
                 1.280 
                 3.000 
                 1.452 
               
               
                 87778000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:109121001- 
                 Numa1 
                 3.674 
                 1.023 
                 1.723 
                 1.433 
                 3.170 
                 0.504 
               
               
                 109122000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:10945001- 
                 Nlrp4d 
                 4.326 
                 2.608 
                 2.723 
                 1.280 
                 3.000 
                 1.326 
               
               
                 10946000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:114032001- 
                 Olfr706 
                 4.954 
                 2.023 
                 3.308 
                 3.017 
                 1.585 
                 3.370 
               
               
                 114033000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:135137001- 
                 Pycard 
                 4.674 
                 2.023 
                 2.723 
                 2.433 
                 3.000 
                 1.674 
               
               
                 135138000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:22454001- 
                 Gm4545 
                 0.867 
                 0.871 
                 1.723 
                 1.280 
                 −0.152 
                 1.019 
               
               
                 22455000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:66704001- 
                 SNORD115 
                 2.867 
                 1.023 
                 1.571 
                 1.280 
                 3.170 
                 −0.303 
               
               
                 66705000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:68880001- 
                 Mir344e 
                 3.867 
                 2.023 
                 1.571 
                 2.433 
                 2.585 
                 1.282 
               
               
                 68881000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:79223001- 
                 Mctp2 
                 4.189 
                 1.023 
                 2.723 
                 2.433 
                 2.322 
                 1.867 
               
               
                 79224000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr7:92563001- 
                 Vmn2r69 
                 4.674 
                 3.023 
                 1.723 
                 2.433 
                 3.170 
                 1.504 
               
               
                 92564000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:46798001- 
                 Sorbs2 
                 4.452 
                 0.871 
                 3.723 
                 2.433 
                 3.170 
                 1.282 
               
               
                 46799000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:48627001- 
                 Rwdd4a 
                 4.326 
                 2.023 
                 1.723 
                 2.433 
                 4.392 
                 −0.066 
               
               
                 48628000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr8:55162001- 
                 Vegfc 
                 3.867 
                 0.871 
                 3.308 
                 1.433 
                 2.000 
                 1.867 
               
               
                 55163000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:103220001- 
                 Topbp1 
                 5.115 
                 2.608 
                 3.308 
                 3.433 
                 2.585 
                 2.530 
               
               
                 103221000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:108982001- 
                 Ccdc72 
                 3.867 
                 1.023 
                 2.723 
                 1.433 
                 4.322 
                 −0.455 
               
               
                 108983000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:39200001- 
                 Olfr951 
                 5.037 
                 3.831 
                 1.571 
                 2.433 
                 4.170 
                 0.867 
               
               
                 39201000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:54323001- 
                 Dmxl2 
                 4.954 
                 3.023 
                 1.723 
                 3.017 
                 3.907 
                 1.048 
               
               
                 54324000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:73361001- 
                 Unc13c 
                 4.567 
                 2.608 
                 1.571 
                 3.433 
                 2.585 
                 1.982 
               
               
                 73362000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chr9:7763001- 
                 Tmem123 
                 4.189 
                 1.023 
                 2.723 
                 1.433 
                 3.322 
                 0.867 
               
               
                 7764000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 ChrX:144496001- 
                 U3 
                 2.867 
                 0.871 
                 1.723 
                 1.433 
                 1.585 
                 1.282 
               
               
                 144497000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 ChrX:51094001- 
                 Xlr 
                 4.037 
                 3.023 
                 1.723 
                 1.280 
                 2.585 
                 1.452 
               
               
                 51095000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 ChrX:74032001- 
                 5S_rRNA 
                 2.867 
                 1.023 
                 1.571 
                 1.433 
                 2.585 
                 0.282 
               
               
                 74033000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 ChrX:91596001- 
                 snoU13 
                 3.674 
                 1.023 
                 1.571 
                 2.433 
                 2.000 
                 1.674 
               
               
                 91597000 
                   
                   
                   
                   
                   
                   
                   
               
               
                 ChrX:98440001- 
                 U11 
                 4.189 
                 2.023 
                 2.723 
                 1.280 
                 3.700 
                 0.489 
               
               
                 98441000