Patent Publication Number: US-8119654-B2

Title: Indenoisoquinolinone analogs and methods of use thereof

Description:
1. REFERENCE TO RELATED APPLICATIONS 
     This application claims priority to U.S. Provisional Application No. 60/904,393, filed on Feb. 28, 2007, the disclosure of which is incorporated by reference herein in its entirety. 
    
    
     2. FIELD OF THE INVENTION 
     The present invention relates to Indenoisoquinolinone Analogs, compositions comprising an effective amount of an Indenoisoquinolinone Analog and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, neuropathy, erectile dysfunction or urinary incontinence, comprising administering to a subject in need thereof an effective amount of an Indenoisoquinolinone Analog. 
     3. BACKGROUND OF THE INVENTION 
     Erectile dysfunction (“ED”) is a significant male-health issue. While estimating its prevalence is difficult, estimates range from about 15 million to 30 million sufferers worldwide. 
     The etiology of erectile dysfunction can be multiple, and can include mechanical trauma to the nerves (such as during prostatectomy), or it can be due to diabetes mellitus, cardiovascular diseases, induced by radiation, certain drugs, or advanced age. 
     Urinary incontinence affects people of all ages and levels of physical health, both in health care settings and in the community at large. Persons suffering from urinary incontinence can be predisposed to also having urinary-tract infections, pressure ulcers, perineal rashes and urosepsis. Psychosocially, urinary incontinence can be associated with embarrassment, social stigmatization, depression and a risk of institutionalization (Herzo et al., Annu. Rev. Gerontol. Geriatr. 9:74 (1989)). 
     An inflammatory disease, such as arthritis, colitis, and autoimmune diabetes, typically manifests itself as a disorder distinct from that associated with a reperfusion injury, e.g., stroke and heart attack, and can clinically manifest itself as a different entity. However, there can be common underlying mechanisms between these two types of disorders. Specifically, inflammatory disease and reperfusion injury can induce proinflammatory cytokine and chemokine synthesis which can, in turn, result in production of cytotoxic free radicals such as nitric oxide and superoxide. NO and superoxide can react to form peroxynitrite (ONOO − ) (Szabó et al., Shock 6:79-88, 1996). 
     The ONOO − -induced cell necrosis observed in inflammatory disease and in reperfusion injury involves the activation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP). Activation of PARP is thought to be an important step in the cell-mediated death observed in inflammation and reperfusion injury (Szabó al, Trends Pharmacol. Sci. 19:287-98, 1998). 
     A number of PARP inhibitors have been described in the art. See, e.g., Banasik et al., J. Biol. Chem., 267:1569-75, 1992, and Banasik et al., Mol. Cell. Biochem., 138:185-97, 1994; WO 00/39104; WO 00/39070; WO 99/59975; WO 99/59973; WO 99/11649; WO 99/11645; WO 99/11644; WO 99/11628; WO 99/11623; WO 99/11311; WO 00/42040; Zhang et al., Biochem. Biophys. Res. Commun., 278:590-98, 2000; White et al, J. Med. Chem., 43:4084-4097, 2000; Griffin et al., J. Med. Chem., 41:5247-5256, 1998; Shinkwin et al., Bioorg. Med. Chem., 7:297-308, 1999; and Soriano et al., Nature Medicine, 7:108-113, 2001. Adverse effects associated with administration of PARP inhibitors have been discussed in Milan et al., Science, 223:589-591, 1984. 
     Indenoisoquinolinone compounds have been previously discussed in the art. For example, cytotoxic non-camptothecin topoisomerase I inhibitors are reported in Cushman et al., J. Med. Chem., 43:3688-3698, 2300 and Cushman et al., J. Med. Chem. 42:446-57, 1999; indeno[1,2-c]isoquinolines are reported as antineoplastic agents in Cushman et al., WO 00/21537; and as neoplasm inhibitors in Hrbata et al., WO 93/05023. 
     Syntheses of indenoisoquinolinone compounds have been reported. For example, see Wawzonek et al., Org. Prep. Proc. Int., 14:163-8, 1982; Wawzonek et al., Can. J. Chem., 59:2833, 1981; Andoi et al, Bull. Chem. Soc. Japan, 47:1014-17, 1974; Dusemund et al., Arch. Pharm (Weinheim, Ger.), 3 17:381-2, 1984; and Lal et al., Indian J. Chem., Sect. B, 38B:33-39, 1999. 
     There remains, however, a need in the art for compounds useful for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, neuropathy, erectile dysfunction or urinary incontinence. 
     Citation of any reference in Section 3 of this application is not an admission that the reference is prior art. 
     4. SUMMARY OF THE INVENTION 
     In one aspect the invention provides a compound of Formula (Ia) 
                         
and pharmaceutically acceptable salts thereof,
 
wherein
 
     X is —N(C 1 -C 4  alkyl)-, —CH(OH)—, —N(C(O)N(H)—(CH 2 ) p —Z)— or —N((CH 2 ) q —Z)—; 
     R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) or —O—(CH 2 ) m —N(R 2 )(R 2 ); 
     each R 2  is independently —H, —C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, —C 1 -C 6  alkylene phenyl, phenyl, an N-terminal alpha amino acid residue, an N-terminal alpha amino hydroxymethyl residue, a C 1 -C 6  alkyl ester of an N-terminal alpha amino acid residue, or a nitrogen-containing 3- to 7-membered monocyclic heterocycle, each of which other than hydrogen is independently unsubstituted or substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH, —C 1 -C 6  alkyl, —O—C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, —(C 1 -C 6  alkyl-substituted) 3- to 7-membered monocyclic heterocycle, or —N(Z 3 )(Z 4 ), where Z 3  and Z 4  are independently —H, —C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, benzyl, or —C 3 -C 8  monocyclic cycloalkyl, each of which other than hydrogen is independently unsubstituted or substituted with one or more of -halo, —OH, —N(R a ) 2 , —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, —NH 2 , a nitrogen-containing 3- to 7-membered monocyclic heterocycle, or a —(C 1 -C 6  alkyl-substituted) nitrogen-containing 3- to 7-membered monocyclic heterocycle, wherein each occurrence of R a  is independently —H, benzyl, or —C 1 -C 10  alkyl; or N, Z 3  and Z 4  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one or more of —C 1 -C 5  alkyl, phenyl, -(phenyl-substituted) C 1 -C 5  alkyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —(C 1 -C 5  alkylene)-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, benzyl, or —C 1 -C 10  alkyl; or N and both R a  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle; 
     or N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle or a nitrogen-containing 7- to 10-membered bicyclic heterocycle, each of which is unsubstituted or substituted with one or more of —C 1 -C 5  alkyl, —C 3 -C 8  monocyclic cycloalkyl, phenyl, a nitrogen-containing 3- to 7-membered monocyclic heterocycle, -(phenyl-substituted) C 1 -C 5  alkyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —C 1 -C 5  alkylene-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C 3 -C 8  monocyclic cycloalkyl, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, —C 1 -C 10  alkyl; or N and both R a  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle; 
     Z is —CF 3 , —F, —OH or —O—CH 3 ; 
     n is an integer ranging from 1 to 10; 
     m is an integer ranging from 2 to 10; 
     p is an integer ranging from 1 to 5; and 
     q is an integer ranging from 1 to 5. 
     In one aspect the invention provides a compound of Formula (Ib) 
                         
and pharmaceutically acceptable salts thereof,
 
wherein
 
     X is —N(C 1 -C 4  alkyl)-, —CH(OH)—, —N(C(O)N(H)—(CH 2 ) p —Z)— or —N((CH 2 ) q —Z)—; 
     R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) or —O—(CH 2 ) m —N(R 2 )(R 2 ); 
     each R 2  is independently —H, —C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, —C 1 -C 6  alkylene phenyl, phenyl, an N-terminal alpha amino acid residue, an N-terminal alpha amino hydroxymethyl residue, a C 1 -C 6  alkyl ester of an N-terminal alpha amino acid residue, or a nitrogen-containing 3- to 7-membered monocyclic heterocycle, each of which other than hydrogen is independently unsubstituted or substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH, —C 1 -C 6  alkyl, —O—C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, —(C 1 -C 6  alkyl-substituted) 3- to 7-membered monocyclic heterocycle, or —N(Z 3 )(Z 4 ), where Z 3  and Z 4  are independently —H, —C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, benzyl, or —C 3 -C 8  monocyclic cycloalkyl, each of which other than hydrogen is independently unsubstituted or substituted with one or more of -halo, —OH, —N(R a ) 2 , —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, —NH 2 , a nitrogen-containing 3- to 7-membered monocyclic heterocycle, or a —(C 1 -C 6  alkyl-substituted) nitrogen-containing 3- to 7-membered monocyclic heterocycle, wherein each occurrence of R a  is independently —H, benzyl, or —C 1 -C 10  alkyl; or N, Z 3  and Z 4  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one or more of —C 1 -C 5  alkyl, phenyl, -(phenyl-substituted) C 1 -C 5  alkyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —(C 1 -C 5  alkylene)-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, benzyl, or —C 1 -C 10  alkyl; or N and both R a  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle; 
     or N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle or a nitrogen-containing 7- to 10-membered bicyclic heterocycle, each of which is unsubstituted or substituted with one or more of —C 1 -C 5  alkyl, —C 3 -C 8  monocyclic cycloalkyl, phenyl, a nitrogen-containing 3- to 7-membered monocyclic heterocycle, -(phenyl-substituted) C 1 -C 5  alkyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —C 1 -C 5  alkylene-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C 3 -C 8  monocyclic cycloalkyl, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, —C 1 -C 10  alkyl; or N and both R a  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle; 
     Z is —CF 3 , —F, —OH or —O—CH 3 ; 
     n is an integer ranging from 1 to 10; 
     m is an integer ranging from 2 to 10; 
     p is an integer ranging from 1 to 5; and 
     q is an integer ranging from 1 to 5. 
     In one aspect the invention provides a compound of Formula (Ic) 
                         
and pharmaceutically acceptable salts thereof,
 
wherein
 
     X is —N(C 1 -C 4  alkyl)-, —CH(OH)—, —N(C(O)N(H)—(CH 2 ) p —Z)— or —N((CH 2 ) q —Z)—; 
     R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) or —O—(CH 2 ) m —N(R 2 )(R 2 ); 
     each R 2  is independently —H, —C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, —C 1 -C 6  alkylene phenyl, phenyl, an N-terminal alpha amino acid residue, an N-terminal alpha amino hydroxymethyl residue, a C 1 -C 6  alkyl ester of an N-terminal alpha amino acid residue, or a nitrogen-containing 3- to 7-membered monocyclic heterocycle, each of which other than hydrogen is independently unsubstituted or substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH, —C 1 -C 6  alkyl, —O—C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, —(C 1 -C 6  alkyl-substituted) 3- to 7-membered monocyclic heterocycle, or —N(Z 3 )(Z 4 ), where Z 3  and Z 4  are independently —H, —C 1 -C 5  alkyl, (C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, benzyl, or —C 3 -C 8  monocyclic cycloalkyl, each of which other than hydrogen is independently unsubstituted or substituted with one or more of -halo, —OH, —N(R a ) 2 , —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, —NH 2 , a nitrogen-containing 3- to 7-membered monocyclic heterocycle, or a —(C 1 -C 6  alkyl-substituted) nitrogen-containing 3- to 7-membered monocyclic heterocycle, wherein each occurrence of R a  is independently —H, benzyl, or —C 1 -C 10  alkyl; or N, Z 3  and Z 4  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one or more of —C 1 -C 5  alkyl, phenyl, -(phenyl-substituted) C 1 -C 5  alkyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —(C 1 -C 5  alkylene)-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, benzyl, or —C 1 -C 10  alkyl; or N and both R a  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle; 
     or N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle or a nitrogen-containing 7- to 10-membered bicyclic heterocycle, each of which is unsubstituted or substituted with one or more of —C 1 -C 5  alkyl, —C 3 -C 8  monocyclic cycloalkyl, phenyl, a nitrogen-containing 3- to 7-membered monocyclic heterocycle, -(phenyl-substituted) C 1 -C 5  alkyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —C 1 -C 5  alkylene-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C 3 -C 8  monocyclic cycloalkyl, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, —C 1 -C 10  alkyl; or N and both R a  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle; 
     Z is —CF 3 , —F, —OH or —O—CH 3 ; 
     n is an integer ranging from 1 to 10; 
     m is an integer ranging from 2 to 10; 
     p is an integer ranging from 1 to 5; and 
     q is an integer ranging from 1 to 5. 
     In another aspect the invention provides a compound of Formula (IIa) 
                         
and pharmaceutically acceptable salts thereof;
 
wherein
 
     X is —CH 2 —, —O—, —C(O)—, —CH(OH)—, —NH—, —N(C 1 -C 4  alkyl)- or —S—; 
     R 1  is —(CH 2 ) n —N(R 2 )(R 3 ) or 
     
       
         
         
             
             
         
       
     
     R 2  is —H, —C 1 -C 6  alkyl, or —C 3 -C 8  monocyclic cycloalkyl; 
     R 3  is —C(O)—(C 1 -C 6  alkylene)-(3- to 7-membered monocyclic heterocycle), a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one or more of —C(O)O—C 1 -C 6  alkyl, or —C 3 -C 8  monocyclic cycloalkyl which is substituted with one or more of (hydroxy-substituted) C 1 -C 5  alkyl groups; 
     or N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with one or more of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)-(nitrogen-containing 3- to 7-membered monocyclic heterocycle) or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle) groups; and 
     an n is an integer ranging from 1 to 10. 
     In another aspect the invention provides a compound of Formula (IIb) 
                         
and pharmaceutically acceptable salts thereof,
 
wherein
 
     X is —CH 2 —, —O—, —C(O)—, —CH(OH)—, —NH—, —N(C 1 -C 4  alkyl)- or —S—; 
     R 1  is —(CH 2 ) n —N(R 2 )(R 3 ) or 
     
       
         
         
             
             
         
       
     
     R 2  is —H, —C 1 -C 6  alkyl, or —C 3 -C 8  monocyclic cycloalkyl; 
     R 3  is —C(O)—(C 1 -C 6  alkylene)-(3- to 7-membered monocyclic heterocycle), a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one or more of —C(O)O—C 1 -C 6  alkyl, or —C 3 -C 8  monocyclic cycloalkyl which is substituted with one or more of (hydroxy-substituted) C 1 -C 5  alkyl groups; 
     or N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with one or more of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)— (nitrogen-containing 3- to 7-membered monocyclic heterocycle) or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle) groups; and 
     an n is an integer ranging from 1 to 10. 
     In another aspect the invention provides a compound of Formula (IIc) 
                         
and pharmaceutically acceptable salts thereof,
 
wherein
 
     X is —CH 2 —, —O—, —C(O)—, —CH(OH)—, —NH—, —N(C 1 -C 4  alkyl)- or —S—; 
     R 1  is —(CH 2 ) n —N(R 2 )(R 3 ) or 
     
       
         
         
             
             
         
       
     
     R 2  is —H, —C 1 -C 6  alkyl, or —C 3 -C 8  monocyclic cycloalkyl; 
     R 3  is —C(O)—(C 1 -C 6  alkylene)-(3- to 7-membered monocyclic heterocycle), a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one or more of —C(O)O—C 1 -C 6  alkyl, or —C 3 -C 8  monocyclic cycloalkyl which is substituted with one or more of (hydroxy-substituted) C 1 -C 5  alkyl groups; 
     or N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with one or more of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)— (nitrogen-containing 3- to 7-membered monocyclic heterocycle) or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle) groups; and 
     an n is an integer ranging from 1 to 10. 
     In one aspect, the invention provides the following Indenoisoquinolinone Analogs according to Formula (IIIa) as set forth below: 
     
       
         
           
               
               
            
               
                   
               
               
                   
                 (IIIa) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Compound 
                 —R 1   
               
               
                   
               
               
                   
                 IIIa-1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-8 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIa-24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     and pharmaceutically acceptable salts thereof. 
     In another aspect, the invention provides the following Indenoisoquinolinone Analogs according to Formula (IIIb) as set forth below: 
     
       
         
           
               
               
            
               
                   
               
               
                   
                 (IIIb) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Compound 
                 —R 1   
               
               
                   
               
               
                   
                 IIIb-1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-8 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 IIIb-24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     and pharmaceutically acceptable salts thereof. 
     In one aspect the invention provides a compound of Formula (IVa) 
                         
and pharmaceutically acceptable salts thereof,
 
wherein
 
     X is —O—, —CH 2 —, —C(O)—, —NH—, —S—, —N(C 1 -C 4  alkyl)-, —CH(OH)—, —N(C(O)N(H)—(CH 2 ) p —Z)— or —N((CH 2 ) q —Z)—; 
     R 1  is —O—C(C 1 -C 3  alkyl) 2 -(CH 2 ) n —N(R 2 )(R 2 ); 
     each R 2  is independently —H, —C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, —C 1 -C 6  alkylene phenyl, phenyl, an N-terminal alpha amino acid residue, an N-terminal alpha amino hydroxymethyl residue, a C 1 -C 6  alkyl ester of an N-terminal alpha amino acid residue, or a nitrogen-containing 3- to 7-membered monocyclic heterocycle, each of which other than hydrogen is independently unsubstituted or substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH, —C 1 -C 6  alkyl, —O—C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, —(C 1 -C 6  alkyl-substituted) 3- to 7-membered monocyclic heterocycle, or —N(Z 3 )(Z 4 ), where Z 3  and Z 4  are independently —H, —C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, benzyl, or —C 3 -C 8  monocyclic cycloalkyl, each of which other than hydrogen is independently unsubstituted or substituted with one or more of -halo, —OH, —N(R a ) 2 , —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, —NH 2 , a nitrogen-containing 3- to 7-membered monocyclic heterocycle, or a —(C 1 -C 6  alkyl-substituted) nitrogen-containing 3- to 7-membered monocyclic heterocycle, wherein each occurrence of R a  is independently —H, benzyl, or —C 1 -C 10  alkyl; or N, Z 3  and Z 4  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one or more of —C 1 -C 5  alkyl, phenyl, -(phenyl-substituted) C 1 -C 5  alkyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —(C 1 -C 5  alkylene)-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, benzyl, or —C 1 -C 10  alkyl; or N and both R a  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle; 
     or N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle or a nitrogen-containing 7- to 10-membered bicyclic heterocycle, each of which is unsubstituted or substituted with one or more of —C 1 -C 5  alkyl, —C 3 -C 8  monocyclic cycloalkyl, phenyl, a nitrogen-containing 3- to 7-membered monocyclic heterocycle, -(phenyl-substituted) C 1 -C 5  alkyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —C 1 -C 5  alkylene-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C 3 -C 8  monocyclic cycloalkyl, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, —C 1 -C 10  alkyl; or N and both R a  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle; 
     Z is —CF 3 , —F, —OH or —O—CH 3 ; 
     n is an integer ranging from 1 to 10; 
     p is an integer ranging from 1 to 5; and 
     q is an integer ranging from 1 to 5. 
     In one aspect the invention provides a compound of Formula (IVb) 
                         
and pharmaceutically acceptable salts thereof,
 
wherein
 
     X is —O—, —CH 2 —, —C(O)—, —NH—, —S—, —N(C 1 -C 4  alkyl)-, —CH(OH)—, —N(C(O)N(H)—(CH 2 ) p —Z)— or —N((CH 2 ) q —Z)—; 
     R 1  is —O—C(C 1 -C 3  alkyl) 2 -(CH 2 ) n —N(R 2 )(R 2 ); 
     each R 2  is independently —H, —C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, —C 1 -C 6  alkylene phenyl, phenyl, an N-terminal alpha amino acid residue, an N-terminal alpha amino hydroxymethyl residue, a C 1 -C 6  alkyl ester of an N-terminal alpha amino acid residue, or a nitrogen-containing 3- to 7-membered monocyclic heterocycle, each of which other than hydrogen is independently unsubstituted or substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH, —C 1 -C 6  alkyl, —O—C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, —(C 1 -C 6  alkyl-substituted) 3- to 7-membered monocyclic heterocycle, or —N(Z 3 )(Z 4 ), where Z 3  and Z 4  are independently —H, —C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, benzyl, or —C 3 -C 8  monocyclic cycloalkyl, each of which other than hydrogen is independently unsubstituted or substituted with one or more of -halo, —OH, —N(R a ) 2 , —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, —NH 2 , a nitrogen-containing 3- to 7-membered monocyclic heterocycle, or a —(C 1 -C 6  alkyl-substituted) nitrogen-containing 3- to 7-membered monocyclic heterocycle, wherein each occurrence of R a  is independently —H, benzyl, or —C 1 -C 10  alkyl; or N, Z 3  and Z 4  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one or more of —C 1 -C 5  alkyl, phenyl, -(phenyl-substituted) C 1 -C 5  alkyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —(C 1 -C 5  alkylene)-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, benzyl, or —C 1 -C 10  alkyl; or N and both R a  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle; 
     or N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle or a nitrogen-containing 7- to 10-membered bicyclic heterocycle, each of which is unsubstituted or substituted with one or more of —C 1 -C 5  alkyl, —C 3 -C 8  monocyclic cycloalkyl, phenyl, a nitrogen-containing 3- to 7-membered monocyclic heterocycle, -(phenyl-substituted) C 1 -C 5  alkyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —C 1 -C 5  alkylene-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C 3 -C 8  monocyclic cycloalkyl, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, —C 1 -C 10  alkyl; or N and both R a  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle; 
     Z is —CF 3 , —F, —OH or —O—CH 3 ; 
     n is an integer ranging from 1 to 10; 
     p is an integer ranging from 1 to 5; and 
     q is an integer ranging from 1 to 5. 
     In one aspect the invention provides a compound of Formula (IVc) 
                         
and pharmaceutically acceptable salts thereof,
 
wherein
 
     X is —O—, —CH 2 —, —C(O)—, —NH—, —S—, —N(C 1 -C 4  alkyl)-, —CH(OH)—, —N(C(O)N(H)—(CH 2 ) p —Z)— or —N((CH 2 ) q —Z)—; 
     R 1  is —O—C(C 1 -C 3  alkyl) 2 -(CH 2 ) n —N(R 2 )(R 2 ); 
     each R 2  is independently —H, —C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, —C 1 -C 6  alkylene phenyl, phenyl, an N-terminal alpha amino acid residue, an N-terminal alpha amino hydroxymethyl residue, a C 1 -C 6  alkyl ester of an N-terminal alpha amino acid residue, or a nitrogen-containing 3- to 7-membered monocyclic heterocycle, each of which other than hydrogen is independently unsubstituted or substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH, —C 1 -C 6  alkyl, —O—C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, —(C 1 -C 6  alkyl-substituted) 3- to 7-membered monocyclic heterocycle, or —N(Z 3 )(Z 4 ), where Z 3  and Z 4  are independently —H, —C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, benzyl, or —C 3 -C 8  monocyclic cycloalkyl, each of which other than hydrogen is independently unsubstituted or substituted with one or more of -halo, —OH, —N(R a ) 2 , —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, —NH 2 , a nitrogen-containing 3- to 7-membered monocyclic heterocycle, or a —(C 1 -C 6  alkyl-substituted) nitrogen-containing 3- to 7-membered monocyclic heterocycle, wherein each occurrence of R a  is independently —H, benzyl, or —C 1 -C 10  alkyl; or N, Z 3  and Z 4  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one or more of —C 1 -C 5  alkyl, phenyl, -(phenyl-substituted) C 1 -C 5  alkyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —(C 1 -C 5  alkylene)-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, benzyl, or —C 1 -C 10  alkyl; or N and both R a  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle; 
     or N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle or a nitrogen-containing 7- to 10-membered bicyclic heterocycle, each of which is unsubstituted or substituted with one or more of —C 1 -C 5  alkyl, —C 3 -C 8  monocyclic cycloalkyl, phenyl, a nitrogen-containing 3- to 7-membered monocyclic heterocycle, -(phenyl-substituted) C 1 -C 5  alkyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —C 1 -C 5  alkylene-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C 3 -C 8  monocyclic cycloalkyl, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, —C 1 -C 10  alkyl; or N and both R a  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle; 
     Z is —CF 3 , —F, —OH or —O—CH 3 ; 
     n is an integer ranging from 1 to 10; 
     p is an integer ranging from 1 to 5; and 
     q is an integer ranging from 1 to 5. 
     In one aspect, the invention provides a compound of Formula (Va) 
                         
and pharmaceutically acceptable salts thereof,
 
wherein
 
     R 1  is —CH 2 NH—R 2 ; 
     R 2  is a —C 3 -C 8  monocyclic cycloalkyl which is unsubstituted or substituted with one or more of -(hydroxy-substituted) C 1 -C 5  alkyl; or a 3- to 7-membered monocyclic heterocycle; 
     X is halo or —H; and 
     Y′ is halo or —H, wherein at least one of X and Y′ is halo. 
     The invention provides compositions comprising an effective amount of a compound of Formula (Ia), (Ib), (Ic), (IIa), (IIb), (IIc), (IIIa), (IIIb), (IVa), (IVb), (IVc), (Va), or a pharmaceutically acceptable salt thereof and a physiologically acceptable carrier or vehicle. 
     The invention further provides methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, neuropathy, erectile dysfunction or urinary incontinence (each being a “Condition”), comprising administering to a subject in need thereof an effective amount of an Indenoisoquinolinone Analog of Formula (Ia), (Ib), (Ic), (IIa), (IIb), (IIc), (IIIa), (IIIb), (IVa), (IVb), (IVc), (Va), or a pharmaceutically acceptable salt thereof. 
     A compound of Formula (Ia), Formula (Ib), Formula (Ic), Formula (Ia), Formula (IIb), Formula (IIc), Formula (IIIa), Formula (IIIb), Formula (IVa), Formula (IVb), Formula (IVc), Formula (Va), or a pharmaceutically acceptable salt thereof (an “Indenoisoquinolinone Analog”) is useful for treating or preventing a Condition. 
     A composition comprising an effective amount of an Indenoisoquinolinone Analog and a physiologically acceptable carrier or vehicle is useful for treating or preventing a Condition. 
     The details of the invention are set forth in the accompanying description below. 
     All patents and publications cited in this specification are incorporated by reference in their entirety. 
    
    
     5. DETAILED DESCRIPTION OF THE INVENTION 
     5.1 Definitions and Abbreviations 
     The following definitions are used in connection with the Indenoisoquinolinone Analogs: 
     The term “—C 1 -C 3  alkyl” as used herein, refers to a straight chain or branched non-cyclic hydrocarbon having from 1 to 3 carbon atoms, wherein one of the hydrocarbon&#39;s hydrogen atoms has been replaced by a single bond. Representative straight chain —C 1 -C 3  alkyls include -methyl, -ethyl, and -n-propyl. Representative branched —C 1 -C 3  alkyls include -isopropyl. 
     The term “—C 1 -C 4  alkyl” as used herein, refers to a straight chain or branched non-cyclic hydrocarbon having from 1 to 4 carbon atoms, wherein one of the hydrocarbon&#39;s hydrogen atoms has been replaced by a single bond. Representative straight chain —C 1 -C 4  alkyls include -methyl, -ethyl, -n-propyl, and -n-butyl. Representative branched —C 1 -C 4  alkyls include -isopropyl, -sec-butyl, -isobutyl and -tert-butyl. In one embodiment, the —C 1 -C 4  alkyl is substituted with one or more of -halo, —OH, —N(R 3 ) 2 , —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, —NH 2 , a nitrogen-containing 3- to 7-membered monocyclic heterocycle, or an —(C 1 -C 6  alkyl-substituted) nitrogen-containing 3- to 7-membered monocyclic heterocycle. Unless otherwise indicated, the —C 1 -C 4  alkyl is unsubstituted. 
     A “C 1 -C 4  alkylene” refers to a C 1 -C 4  alkyl group, as defined above, wherein one of the C 1 -C 4  alkyl group&#39;s hydrogen atoms has been replaced with a bond. 
     A “C 2 -C 4  alkylene” refers to a straight or branched chain saturated hydrocarbon containing 2-4 carbon atoms, wherein two of the hydrocarbon&#39;s hydrogen atoms have been replaced by a single a bond. Representative C 2 -C 4  alkylene groups include, ethylene, n-propylene, isopropylene, n-butylene and isobutylene. 
     The term “—C 1 -C 5  alkyl” as used herein, refers to a straight chain or branched non-cyclic hydrocarbon having from 1 to 5 carbon atoms, wherein one of the hydrocarbon&#39;s hydrogen atoms has been replaced by a single bond. Representative straight chain —C 1 -C 5  alkyls include -methyl, -ethyl, -n-propyl, -n-butyl and -n-pentyl. Representative branched —C 1 -C 5  alkyls include -isopropyl, -sec-butyl, -isobutyl, -tert-butyl, -isopentyl, -neopentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 1,1-dimethylpropyl and 1,2-dimethylpropyl. In one embodiment, the —C 1 -C 5  alkyl is substituted with one or more of -halo, —OH, —N(R 3 ) 2 , —C 1 -C 5  alkylene-O—C 1 -C 5  alkyl, —NH 2 , a nitrogen-containing 3- to 7-membered monocyclic heterocycle, or an —C 1 -C 6  alkyl-substituted nitrogen-containing 3- to 7-membered monocyclic heterocycle. Unless otherwise indicated, the —C 1 -C 5  alkyl is unsubstituted. 
     A “C 1 -C 5  alkylene” refers to a C 1 -C 5  alkyl group, as defined above, wherein one of the C 1 -C 5  alkyl group&#39;s hydrogen atoms has been replaced with a bond. 
     The term “-phenyl-substituted C 1 -C 5  alkyl” as used herein, refers to a “—C 1 -C 5  alkyl” wherein one of the its hydrogen atoms has been replaced by a phenyl group. 
     The term “—C 1 -C 6  alkyl” as used herein, refers to a straight chain or branched non-cyclic hydrocarbon having from 1 to 6 carbon atoms, wherein one of the hydrocarbon&#39;s hydrogen atoms has been replaced by a single bond. Representative straight chain —C 1 -C 6  alkyls include -methyl, -ethyl, -n-propyl, -n-butyl, -n-pentyl and -n-hexyl. Representative branched —C 1 -C 6  alkyls include -isopropyl, -sec-butyl, -isobutyl, -tert-butyl, -isopentyl, -neopentyl, -1-methylbutyl, -isohexyl, -neohexyl, -2-methylbutyl, -3-methylbutyl, -1,1-dimethylpropyl and -1,2-dimethylpropyl. In one embodiment, the —C 1 -C 6  alkyl is substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH, —C 1 -C 6  alkyl, —O—C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, —(C 1 -C 6  alkyl-substituted) 3- to 7-membered monocyclic heterocycle, or —N(Z 3 )(Z 4 ). Unless otherwise indicated, the —C 1 -C 6  alkyl is unsubstituted. 
     A “C 1 -C 6  alkylene” refers to a C 1 -C 6  alkyl group, as defined above, wherein one of the C 1 -C 6  alkyl group&#39;s hydrogen atoms has been replaced with a bond. 
     The term “—C 2 -C 6  alkenyl” refers to a straight or branched chain hydrocarbon containing 2-6 carbon atoms and at least one double bond. Representative C 2 -C 6  alkenyl groups include, but are not limited to, ethylene, propylene, 1-butylene, 2-butylene, isobutylene, sec-butylene, 1-pentene, 2-pentene, isopentene, 1-hexene, 2-hexene, 3-hexene and isohexene. 
     The term “—C 1 -C 8  alkyl” as used herein, refers to a straight chain or branched non-cyclic hydrocarbon having from 1 to 9 carbon atoms, wherein one of the hydrocarbon&#39;s hydrogen atoms has been replaced by a single bond. Representative —C 1 -C 9  alkyls include, methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, -nonyl, isopropyl, isobutyl, sec-butyl and tert-butyl, isopentyl, neopentyl, isohexyl, isoheptyl, isooctyl and isononyl. 
     The term “—C 7 -C 10  alkyl” as used herein, refers to a straight chain or branched non-cyclic hydrocarbon having from 7 to 10 carbon atoms, wherein one of the hydrocarbon&#39;s hydrogen atoms has been replaced by a single bond. Representative —C 7 -C 10  alkyls include, but are not limited to, heptyl, octyl, nonyl, isohexyl, isoheptyl, isooctyl and isononyl, decyl, and isodecyl. 
     The term “—C 1 -C 10  alkyl” as used herein, refers to a straight chain or branched non-cyclic hydrocarbon having from 1 to 10 carbon atoms, wherein one of the hydrocarbon&#39;s hydrogen atoms has been replaced by a single bond. Representative —C 1 -C 10  alkyls include, methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, -nonyl, decyl, isopropyl, isobutyl, sec-butyl and tert-butyl, isopentyl, neopentyl, isohexyl, isoheptyl, isooctyl, isononyl and isodecyl. 
     The term “—C 3 -C 8  monocyclic cycloalkyl” as used herein, refers to a saturated cyclic hydrocarbon having from 3 to 8 carbon atoms. Representative —C 3 -C 8  monocyclic cycloalkyls include -cyclopropyl, -cyclobutyl, -cyclopentyl, -cyclohexyl, -cycloheptyl and -cyclooctyl. In one embodiment, the —C 3 -C 8  monocyclic cycloalkyl is substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH, —C 1 -C 6  alkyl, —O—C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, —C 1 -C 6  alkyl-substituted 3- to 7-membered monocyclic heterocycle. In another embodiment, the —C 3 -C 8  monocyclic cycloalkyl is substituted with one or more of —N(R 3 ) 2 , —C 1 -C 5  alkylene-O—C 1 -C 5  alkyl, or —NH 2 . Unless otherwise indicated, the —C 3 -C 8  monocyclic cycloalkyl is unsubstituted. 
     A “nitrogen containing 3- to 7-membered monocyclic heterocycle” refers to a monocyclic 3- to 7-membered aromatic or non-aromatic monocyclic cycloalkyl group in which one of the cycloalkyl group&#39;s ring carbon atoms has been replaced with a nitrogen atom and 0-4 of the cycloalkyl group&#39;s remaining ring carbon atoms are independently replaced with a N, O or S atom. The nitrogen containing 3- to 7-membered monocyclic heterocycles can be attached via a nitrogen, sulfur, or carbon atom. Representative examples of nitrogen-containing -3- to 7-membered monocyclic heterocycles include, but are not limited to, piperidinyl, piperazinyl, pyrrolyl, piperidonyl, oxazinyl, thiazinyl, diazinyl, triazinyl, tetrazinyl, imidazolyl, tetrazolyl, pyrrolidinyl, isoxazolyl, pyridinyl, oxazolyl, thiazolyl, pyrazolyl, triazolyl, pyrimidinyl, morpholinyl, furuzanyl, pyrrolinyl, imidazolinyl, imidazolidinyl, pyrazolinyl, isothiazolyl, oxadiazolyl, thiadiazolyl, pyridazinyl, pyrazinyl, pyrazolidinyl, and thiomorpholinyl. 
     In one embodiment, the nitrogen-containing 3- to 7-membered monocyclic heterocycle is fully saturated or partially saturated. 
     In another embodiment, the nitrogen-containing 3- to 7-membered monocyclic heterocycle is substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH, —C 1 -C 6  alkyl, —O—C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, —(C 1 -C 6  alkyl-substituted) 3- to 7-membered monocyclic heterocycle, or —N(Z 3 )(Z 4 ). Unless otherwise indicated, the nitrogen-containing 3- to 7-membered monocyclic heterocycle is unsubstituted. 
     A “nitrogen-containing 7- to 10-membered bicyclic heterocycle” refers to a 7- to 10-membered bicyclic ring system that contains at least one ring nitrogen atom. The nitrogen-containing 7- to 10-membered bicyclic heterocycles can be attached via a nitrogen, sulfur, or carbon atom. Representative nitrogen-containing 7- to 10-membered bicyclic heterocycles include -quinolinyl, -isoquinolinyl, -chromonyl, -indolyl, -isoindolyl, -indolinyl, indolizinyl, -indazolyl, -purinyl, -4H-quinolizinyl, -isoquinolyl, -quinolyl, -phthalazinyl, -naphthyridinyl, benzimidazolyl, benzthiazolyl, dihydroquinolyl, dihydroisoquinolyl, cinnolyl, phthalazyl, quinazolyl, quinoxalyl, and pteridyl. 
     In one embodiment, the nitrogen-containing 7- to 10-membered bicyclic heterocycle is saturated or partially saturated. 
     A “3- to 7-membered monocyclic heterocycle” refers to a monocyclic 3- to 7-membered aromatic or non-aromatic monocyclic cycloalkyl in which 1-4 of the ring carbon atoms have been independently replaced with a N, O or S atom. The 3- to 7-membered monocyclic heterocycles can be attached via a nitrogen, sulfur, or carbon atom. Representative examples of a 3- to 7-membered monocyclic heterocycle group include, but are not limited to, nitrogen-containing 3- to 7-membered monocyclic heterocycles discussed above, tetrahydrofuranyl, dihydrofuranyl, pyranyl, dihydropyranyl, tetrahydropyranyl, thiopyranyl, dihydrothiopyranyl, tetrahydrothiopyranyl, dioxanyl, dithianyl, trithianyl, dioxolanyl, furanyl, and thiophenyl. In one embodiment, the 3- to 7-membered monocyclic heterocycle is a nitrogen-containing 3- to 7-membered monocyclic heterocycle. In another embodiment, the 3- to 7-membered monocyclic heterocycle is saturated or partially saturated. 
     A “C 1 -C 6  alkyl-substituted 3- to 7-membered monocyclic heterocycle” refers to a “3- to 7-membered monocyclic heterocycle,” as defined above, wherein one or more of the heterocycle&#39;s hydrogen atoms has been replaced by a C 1 -C 6  alkyl, as defined above. 
     “Halo” is —F, —Cl, —Br or —I. 
     “Halo-substituted C 1 -C 5  alkyl” refers to a C 1 -C 5  alkyl group, as defined above, wherein one or more of the C 1 -C 5  alkyl group&#39;s hydrogen atoms has been replaced with —F, —Cl, —Br or —I. Representative examples of a halo-substituted C 1 -C 5  alkyl include, but are not limited to, —CH 2 F, —CCl 3 , —CF 3 , —CH 2 Cl, —CH 2 CH 2 Br, —CH 2 CH 2 I, —CH 2 CH 2 CH 2 F, —CH 2 CH 2 CH 2 Cl, —CH 2 CH 2 CH 2 CH 2 Br, —CH 2 CH 2 CH 2 CH 2 I, —CH 2 CH 2 CH 2 CH 2 CH 2 Br, —CH 2 CH 2 CH 2 CH 2 CH 2 I, —CH 2 CH(Br)CH 3 , —CH 2 CH(Cl)CH 2 CH 3 , —CH(F)CH 2 CH 3  and —C(CH 3 ) 2 (CH 2 Cl). 
     “Halo-substituted phenyl” refers to a phenyl group, wherein one or more of the phenyl group&#39;s hydrogen atoms has been replaced with —F, Cl, —Br or —I. 
     “Cyano-substituted phenyl” refers to a phenyl group, wherein one or more of the phenyl group&#39;s hydrogen atoms has been replaced with —CN. 
     “Cyano-substituted C 1 -C 5  alkyl” refers to a C 1 -C 5  alkyl group, as defined above, wherein one or more of the C 1 -C 5  alkyl group&#39;s hydrogen atoms has been replaced with —CN. Representative examples of a cyano-substituted C 1 -C 5  alkyl include, but are not limited to, —CH 2 CN, —CH 2 CH 2 CN, —CH 2 CH 2 CH 2 CN, —CH 2 CH 2 CH 2 CH 2 CN, —CH 2 CH 2 CH 2 CH 2 CH 2 CN, —CH 2 CH(CN)CH 3 , —CH 2 CH(CN)CH 2 CH 3 , —CH(CN)CH 2 CH 3  and —C(CH 3 ) 2 (CH 2 CN). 
     A “C 1 -C 6  alkylene phenyl” refers to a C 1 -C 6  alkyl group, as defined above, wherein one of the C 1 -C 6  alkyl group&#39;s hydrogen atoms has been replaced with phenyl. 
     “Hydroxy-substituted C 1 -C 5  alkyl” refers to a C 1 -C 5  alkyl group, as defined above, wherein one or more of the C 1 -C 5  alkyl group&#39;s hydrogen atoms has been replaced with —OH. Representative examples of a hydroxy-substituted C 1 -C 5  alkyl include, but are not limited to, —CH 2 OH, —CH 2 CH 2 OH, —CH 2 CH 2 CH 2 OH, —CH 2 CH 2 CH 2 CH 2 OH, —CH 2 CH 2 CH 2 CH 2 CH 2 OH, —CH 2 CH(OH)CH 3 , —CH 2 CH(OH)CH 2 CH 3 , —CH(OH)CH 2 CH 3  and —C(CH 3 ) 2 (CH 2 OH). 
     A “C-terminal alpha amino acid residue” refers to an L-, D- or racemic natural or unnatural alpha amino acid, less the hydroxyl group of the alpha amino acid&#39;s carboxyl group. Representative examples of a C-terminal alpha amino acid residue include, but are not limited to, CH 3 —CH(NH 2 )—C(O)—, HN═C(NH 2 )—NH—(CH 2 ) 3 —CH(NH 2 )—C(O)—, H 2 N—C(O)—CH 2 —CH(NH 2 )—C(O)—, HOOC—CH 2 —CH(NH 2 )—C(O)—, HS—CH 2 —CH(NH 2 )—C(O)—, H 2 N—C(O)—(CH 2 ) 2 —CH(NH 2 )—C(O)—, HOOC—(CH 2 ) 2 —CH(NH 2 )—C(O)—, H 2 N—CH 2 —C(O)—, CH 3 —CH 2 —CH(CH 3 )—CH(NH 2 )—C(O)—, (CH 3 ) 2 —CH—CH 2 —CH(NH 2 )—C(O)—, H 2 N—(CH 2 ) 4 —CH(NH 2 )—C(O)—, CH 3 —S—(CH 2 ) 2 —CH(NH 2 )—C(O)—, HO—CH 2 —CH(NH 2 )—C(O)—, CH 3 —CH(OH)—CH(NH 2 )—C(O)—, (CH 3 ) 2 —CH—CH(NH 2 )—C(O)—, 
     
       
         
         
             
             
         
       
     
     In one embodiment, the C-terminal alpha amino acid is a natural amino acid. 
     In another embodiment, the C-terminal alpha amino acid is an unnatural amino acid. 
     In one embodiment, the C-terminal alpha amino acid is an L amino acid. 
     An “N-terminal alpha amino acid residue” refers to an L-, D- or racemic natural or unnatural alpha amino acid, less the alpha amino acid&#39;s N-terminal amino group. Representative examples of an N-terminal alpha amino acid residue include, but are not limited to, —CH 2 —COOH, —CH(CH 3 )COOH, —CH(CH(CH 3 ) 2 )COOH, —CH(CH 2 CH(CH 3 ) 2 )COOH, —CH(CH(CH 3 )(CH 2 CH 3 ))COOH, —CH((CH 2 ) 4 —NH 2 )COOH, —CH((CH 2 ) 3 NH(C═NH 2 )—NH 2 )COOH, —CH(CH 2 —OH)COOH, —CH(CH((CH 3 )(OH)))COOH, —CH(CH 2 —COOH)COOH, —CH((CH 2 ) 2 COOH)COOH, —CH((CH 2 )(CONH 2 ))COOH, —CH((CH 2 ) 2 (CONH 2 ))COOH, —CH(CH 2 —SH)COOH, —CH((CH 2 ) 2 —S—CH 3 )COOH, 
     
       
         
         
             
             
         
       
     
     In one embodiment, the N-terminal alpha amino acid residue is substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH, —C 1 -C 6  alkyl, —O—C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, —C 1 -C 6  alkyl-substituted 3- to 7-membered monocyclic heterocycle, or —N(Z 3 )(Z 4 ). Unless otherwise indicated, the N-terminal alpha amino acid residue is unsubstituted. 
     An “N-terminal alpha amino hydroxymethyl residue” refers to an “N-terminal alpha amino acid residue,” wherein its C-terminal carboxyl group, a side chain&#39;s carboxyl group, or both have been replaced with a hydroxymethyl group. In one embodiment, the N-terminal alpha amino hydroxymethyl residue is substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH, —C 1 -C 6  alkyl, —O—C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, —C 1 -C 6  alkyl-substituted 3- to 7-membered monocyclic heterocycle, or —N(Z 3 )(Z 4 ). In another embodiment, the hydroxyl group of the hydroxymethyl residue is substituted with —PO 3 H 2 , —P 2 O 6 H 3 , —P 3 O 9 H 4 , —SO 3 H, —C(O)—C 1 -C 9  alkyl, β-D-glucuronyl, or a C-terminal alpha amino acid residue. Unless otherwise indicated, the N-terminal alpha amino hydroxymethyl residue is unsubstituted. 
     A “C 1 -C 6  alkyl ester of an N-terminal alpha amino acid residue” refers to an “N-terminal alpha amino acid residue,” wherein the hydrogen atom of the amino acid&#39;s C-terminal carboxyl group, a side chain&#39;s carboxyl group, or both have been replaced by a —C 1 -C 6  alkyl group. In one embodiment, the C 1 -C 6  alkyl ester of an N-terminal alpha amino acid residue is a methyl, an ethyl, an n-propyl or an iso-propyl ester of an N-terminal alpha amino acid residue. In another embodiment, the C 1 -C 6  alkyl ester of an N-terminal alpha amino acid residue is substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH, —C 1 -C 6  alkyl, —O—C 1 -C 6  alkyl, —C 3 -C 8  monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, —C 1 -C 6  alkyl-substituted 3- to 7-membered monocyclic heterocycle, or —N(Z 3 )(Z 4 ). Unless otherwise indicated, the C 1 -C 6  alkyl ester of an N-terminal alpha amino acid residue is unsubstituted. 
     In one embodiment, the N-terminal alpha amino acid is a natural amino acid. 
     In another embodiment, the N-terminal alpha amino acid is an unnatural amino acid. 
     In one embodiment, the N-terminal alpha amino acid is an L amino acid. 
     A “β-D-glucuronyl” refers to a group having the formula: 
     
       
         
         
             
             
         
       
     
     A “subject” is a mammal, e.g., a human, mouse, rat, guinea pig, dog, cat, horse, cow, pig, or non-human primate, such as a monkey, chimpanzee, baboon or rhesus. In one embodiment, the subject is a human. 
     The phrase “pharmaceutically acceptable salt,” as used herein, is a salt of an acid and a basic nitrogen atom of an Indenoisoquinolinone Analog. Illustrative salts include, but are not limited, to sulfate, citrate, acetate, oxalate, chloride, bromide, iodide, nitrate, bisulfate, phosphate, acid phosphate, isonicotinate, lactate, salicylate, acid citrate, tartrate, oleate, tannate, pantothenate, bitartrate, ascorbate, succinate, maleate, gentisinate, fumarate, gluconate, glucaronate, saccharate, formate, benzoate, glutamate, methanesulfonate, ethanesulfonate, benzenesulfonate, p-toluenesulfonate, camphorsulfonate, and pamoate (i.e., 1,1′-methylene-bis-(2-hydroxy-3-naphthoate)) salts. The term “pharmaceutically acceptable salt” also refers to a salt of an Indenoisoquinolinone Analog having an acidic functional group, such as a carboxylic acid functional group, and a base. Suitable bases include, but are not limited to, hydroxides of alkali metals such as sodium, potassium, and lithium; hydroxides of alkaline earth metal such as calcium and magnesium; hydroxides of other metals, such as aluminum and zinc; ammonia, and organic amines, such as unsubstituted or hydroxy-substituted mono-, di-, or tri-alkylamines, dicyclohexylamine; tributyl amine; pyridine; N-methyl, N-ethylamine; diethylamine; triethylamine; mono-, bis-, or tris-(2-OH-lower alkylamines), such as mono-; bis-, or tris-(2-hydroxyethyl)amine, 2-hydroxy-tert-butylamine, or tris-(hydroxymethyl)methylamine, N,N-di-lower alkyl-N-(hydroxyl-lower alkyl)-amines, such as N,N-dimethyl-N-(2-hydroxyethyl)amine or tri-(2-hydroxyethyl)amine; N-methyl-D-glucamine; and amino acids such as arginine, lysine, and the like. The term “pharmaceutically acceptable salt” also includes a hydrate of a compound of the invention. 
     In one embodiment, the pharmaceutically acceptable salt is a mesylate salt. 
     In another embodiment, the pharmaceutically acceptable salt is a camphorsulfonate salt. 
     An “effective amount” when used in connection with an Indenoisoquinolinone Analog is an amount that is effective for treating or preventing a Condition. 
     An “effective amount” when used in connection with another anticancer agent is an amount that is effective for treating or preventing cancer alone or in combination with an Indenoisoquinolinone Analog. “In combination with” includes administration within the same composition and via separate compositions. In the latter instance, the other anticancer agent is administered during a time when the Indenoisoquinolinone Analog exerts its prophylactic or therapeutic effect, or vice versa. 
     The following abbreviations are used herein and have the indicated definitions: DMF is N,N-dimethylformamide, THF is tetrahydrofuran, DMAC is dimethylacetamide. DMSO is dimethylsulfoxide, Et is ethyl, Pr is n-propyl, i-Pr is isopropyl, EtOAc is ethyl acetate, EtOH is ethanol, Me is methyl, MS is mass spectrometry, Ts is tosylate, Tf is triflate, Ph is phenyl, NMR is Nuclear Magnetic Resonance, Ms is mesylate, LAH is lithium aluminum hydride and tBoc is t-butyloxycarbonyl. 
     5.2 The Indenoisoquinolinone Analogs of Formula (Ia) 
     The present invention provides Indenoisoquinolinone Analogs according to Formula (Ia), below: 
                         
and pharmaceutically acceptable salts thereof,
 
wherein X and R 1  are as defined above for the Indenoisoquinolinone Analogs of Formula (Ia).
 
     In one embodiment, X is —N(CH 3 )—. In another embodiment, X is —N(CH 2 CH 3 )—. In another embodiment, X is —N(CH 2 CH 2 CH 3 )—. In another embodiment, X is —N(CH 2  CH 2 CH 2 CH 3 )—. In another embodiment, X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. In another embodiment, X is —N(C(H)(CH 3 ) 2 )—. In another embodiment, X is —N(CH 2 C(H)(CH 3 ) 2 )—. In another embodiment, X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 3 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 2 CH 3 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 2 CH 2 CH 3 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 2 CH 2 CH 2 CH 3 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(C(H)(CH 3 ) 2 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 2 C(H)(CH 3 ) 2 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 3 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 2 CH 3 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 2 CH 2 CH 3 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 2 CH 2 CH 2 CH 3 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(C(H)(CH 3 ) 2 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 2 C(H)(CH 3 ) 2 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, one R 2  is —H, and the other R 2  is —C 1 -C 6  alkyl. 
     In another embodiment, each R 2  is —C 1 -C 6  alkyl. 
     In another embodiment, each R 2  is -methyl. 
     In one embodiment, X is —CH(OH)—. 
     In another embodiment, X is —CH(OH)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —CH(OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—Z)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —Z)—. 
     In another embodiment, X is —N((CH 2 )—Z)—. 
     In another embodiment, X is —N((CH 2 ) 2 —Z)—. 
     In another embodiment, X is —N((CH 2 ) q —Z)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —Z)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 )—Z)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, Z is —CF 3 . 
     In another embodiment, Z is —F. 
     In yet another embodiment, Z is —OH. 
     In still another embodiment, Z is —O—CH 3 . 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —OH)—. 
     In another embodiment, X is —N((CH 2 ) 2 —OH)—. 
     In another embodiment, X is —N((CH 2 ) q —OH)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 ) 2 —OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—F)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—F)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —F)—. 
     In another embodiment, X is —N((CH 2 )—F)—. 
     In another embodiment, X is —N((CH 2 ) q —F)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —F)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 )—F)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)-. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OMe)-. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)- and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)- and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OMe)- and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —OMe)-. 
     In another embodiment, X is —N((CH 2 ) 2 —OMe)-. 
     In another embodiment, X is —N((CH 2 ) q —OMe)- and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —OMe)- and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 ) 2 —OMe)- and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —CF 3 )—. 
     In another embodiment, X is —N((CH 2 )—CF 3 )—. 
     In another embodiment, X is —N((CH 2 ) q —CF 3 )— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 )—CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and R 1  is —(CH 2 ) n —N(R 1 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —CF 3 )—. 
     In another embodiment, X is —N((CH 2 )—CF 3 )—. 
     In another embodiment, X is —N((CH 2 ) q —CF 3 )— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 )—CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, n is 1. 
     In another embodiment, n is 2. 
     In yet another embodiment, n is 3. 
     In a further embodiment, n is 4, 5, or 6. 
     In yet a further embodiment, n is 7, 8, or 9. 
     In still a further embodiment, n is 10. 
     In one embodiment, m is 2. 
     In another embodiment, m is 3. 
     In yet another embodiment, m is 4, 5, or 6. 
     In a further embodiment, m is 7, 8, or 9. 
     In yet a further embodiment, m is 10. 
     In one embodiment, p is 1. 
     In another embodiment, p is 2. 
     In yet another embodiment, p is an integer ranging from 2 to 5. 
     In one embodiment, q is 1. 
     In another embodiment, q is 2. 
     In yet another embodiment, q is an integer ranging from 2 to 5. 
     In various embodiments, —N(R 2 )(R 2 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In other embodiments, —N(R 2 )(R 2 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In some embodiments, —N(R 2 )(R 2 ) is 
     
       
         
         
             
             
         
       
     
     In still other embodiments, —N(R 2 )(R 2 ) is
         —N(CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ),   —NH—CH 2 CH 2 CH 2 CH 3 , or   —NH—CH 2 CH 2 —O—CH 3 .       

     In some embodiments, —N(R 2 )(R 2 ) is 
     
       
         
         
             
             
         
       
     
     In various embodiments, —N(Z 3 )(Z 4 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In other embodiments, —N(Z 3 )(Z 4 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In some embodiments, —N(Z 3 )(Z 4 ) is 
     
       
         
         
             
             
         
       
     
     In still other embodiments, —N(Z 3 )(Z 4 ) is
         —N(CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ),   —NH—CH 2 CH 2 CH 2 CH 3 , or   —NH—CH 2 CH 2 —O—CH 3 .       

     In some embodiments, —N(Z 3 )(Z 4 ) is 
     
       
         
         
             
             
         
       
     
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; 
     R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) or —O—(CH 2 ) m —N(R 2 )(R 2 ); 
     each R 2  is independently —H, —C 1 -C 6  alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —(C 1 -C 6  alkylene)-phenyl or -phenyl, each of which other than hydrogen is unsubstituted or substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH or —N(Z 3 )(Z 4 ), where Z 3  and Z 4  are independently —H, —C 1 -C 5  alkyl, or —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, each of which other than hydrogen is unsubstituted or substituted with one or more of -halo, —OH or —NH 2 ; 
     or N, Z 3  and Z 4  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one to three of —C 1 -C 5  alkyl, -phenyl, —(C 1 -C 5  alkylene)-phenyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —C 1 -C 5  alkylene-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, or —C 1 -C 10  alkyl; 
     or N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one to three of —C 1 -C 5  alkyl, -phenyl, —(C 1 -C 5  alkylene)-phenyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —(C 1 -C 5  alkylene)-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, or —C 1 -C 10  alkyl; 
     n is an integer ranging from 1 to 10; and 
     m is an integer ranging from 2 to 10. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is methyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is ethyl. 
     In yet another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is propyl. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is —C 3 -C 8  monocyclic cycloalkyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is cyclohexyl. 
     In yet another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; and R 1  is —CH 2 —N(R 2 )(R 2 ), wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; and R 1  is —CH 2 —N(R 2 )(R 2 ), wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with a hydroxyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; and R 1  is —CH 2 —N(R 2 )(R 2 ), wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with a nitrogen-containing 3- to 7-membered monocyclic heterocycle. 
     Illustrative examples of the Indenoisoquinolinone Analogs include the compounds of Formula (Ia) as set forth below: 
     
       
         
           
               
               
             
               
                   
               
             
            
               
                   
                 (Ia) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Compound 
                 n 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ia-1 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-2 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-3 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-4 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-5 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-6 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-7 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-8 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-9 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-10 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-11 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-12 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-13 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-14 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-15 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-16 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-17 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-18 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-19  
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-20  
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-21  
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-22  
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-23  
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-24  
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-25  
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-26  
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-27  
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-28  
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-29  
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-30  
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-31  
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-32  
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-33  
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-34  
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-35  
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-36  
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-37  
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-38  
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-39  
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-40  
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-41  
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-42  
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-43  
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-44  
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-45  
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-46  
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-47  
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-48  
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-49  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-50  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-51  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-52  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-53  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-54  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-55  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-56  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-57  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-58  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-59  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-60  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-61  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-62  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-63  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-64  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-65  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-66  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-67  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-68  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-69  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-70  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-71  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-72  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-73  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-74  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-75  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-76  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-77  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-78  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-79  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-80  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-81  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-82  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-83  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-84  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-85  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-86  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-87  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-88  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-89  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-90  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-91  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-92  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-93  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-94  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-95  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-96  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Compound 
                 m 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ia-146  
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-147  
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-148  
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-149  
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-150  
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-151  
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-152  
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-153  
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-154  
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-155  
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-156  
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-157  
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-158  
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-159  
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-160  
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-161  
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-162  
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-163  
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-164  
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-165  
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-166  
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-167  
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-168  
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-169  
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-170  
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-171  
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-172  
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-173  
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-174  
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-175  
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-176  
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-178  
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-179  
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-180  
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-181  
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-182  
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-183  
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-184  
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-185  
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-186  
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-187  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-188  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-189  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-190  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-191  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-192  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-193  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-194  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-195  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-196  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-197  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-198  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-199  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-200  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-201  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-202  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-203  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-204  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-205  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-206  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-207  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-208  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-209  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-210  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-211  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-212  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-213  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-214  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-215  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-216  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-217  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-218  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-219  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-220  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-221  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-222  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-223  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-224  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-225  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-226  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Compound 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ia-267  
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-268  
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-269  
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-270  
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-271  
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-272  
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-273  
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-274  
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-275  
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-276  
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-277  
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-278  
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-279  
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-280  
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-281  
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-282  
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-283  
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 3 )— 
               
               
                 Ia-284  
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-285  
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-286  
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-287  
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-288  
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-289  
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-290  
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-291  
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-292  
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-293  
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-294  
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-295  
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-296  
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-297  
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-298  
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-299  
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-300  
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-301  
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-302  
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-303  
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-304  
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-305  
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-306  
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-307  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-308  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-309  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-310  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-311  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-312  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-313  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-314  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-315  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-316  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-317  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-318  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-319  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-320  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-321  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-322  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-323  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-324  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-325  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-326  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-327  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-328  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-329  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-330  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-331  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-332  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-333  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-334  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-335  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-336  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-337  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-338  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-339  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-340  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-341  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-342  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-343  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-344  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-345  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-346  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-347  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-348  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-349  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-350  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-351  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-352  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-353  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-354  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-355  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-356  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-357  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-358  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-359  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-360  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-361  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-362  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-363  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-364  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-365  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-366  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-367  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-368  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-369  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-370  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-371  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-372  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-373  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-374  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-375  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-376  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-377  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-378  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-379  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-380  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-381  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-382  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-383  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-384  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-385  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-386  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-387  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-388  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-389  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-390  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-391  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-392  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-393  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-394  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-395  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-396  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-397  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-398  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-399  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-400  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-401  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-402  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-403  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-404  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-405  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-406  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-407  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-408  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-409  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-410  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-411  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-412  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-413  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-414  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-415  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-416  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-417  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-418  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-419  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-420  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-421  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-422  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-423  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-424  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-425  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-426  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-427  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-428  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-429  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-430  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-431  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-432  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-433  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-434  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-435  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-436  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-437  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-438  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-439  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-440  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-441  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-442  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-443  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-444  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-445  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-446  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-447  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-448  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-449  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-450  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-451  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-452  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-453  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-454  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-455  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-456  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-457  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-458  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-459  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-460  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-461  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-462  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-463  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-464  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-465  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-466  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-467  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-468  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-469  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-470  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-471  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-472  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-473  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-474  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-475  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-476  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-477  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-478  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-479  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-480  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-481  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-482  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-483  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-484  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-485  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-486  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-487  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-488  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-489  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-490  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-491  
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 3 )— 
               
               
                 Ia-492  
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-493  
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-494  
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-495  
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-496  
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-497  
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-498  
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-499  
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 3 )— 
               
               
                 Ia-500  
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-501  
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-502  
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-503  
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-504  
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-505  
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-506  
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-507  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-508  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-509  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-510  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-511  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-512  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-513  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-514  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-515  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-516  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-517  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-518  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-519  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-520  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-521  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-522  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-523  
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-524  
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-525  
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-526  
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-527  
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-528  
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-529  
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-530  
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-531  
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-532  
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-533  
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-534  
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-535  
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-536  
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-537  
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-538  
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-539  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-540  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-541  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-542  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-543  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-544  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-545  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-546  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-547  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-548  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-549  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-550  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-551  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-552  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-553  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-554  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-555  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-556  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-557  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-558  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-559  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-560  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-561  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-562  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-563  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-564  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-565  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-566  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-567  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-568  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-569  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-570  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-571  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-572  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-573  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-574  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-575  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-576  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-577  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-578  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-579  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-580  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-581  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-582  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-583  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-584  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-585  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-586  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-587  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-588  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-589  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-590  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-591  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-592  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-593  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-594  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-595  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-596  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-597  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-598  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-599  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-600  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-601  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-602  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-603  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-604  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-605  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-606  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-607  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-608  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-609  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-610  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-611  
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ia-612  
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-613  
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-614  
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-615  
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-616  
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-617  
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-618  
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-619  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-620  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-621  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-622  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-623  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-624  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-625  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-626  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-627  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-628  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-629  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-630  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-631  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-632  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-633  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-634  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-635  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-636  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-637  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-638  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-639  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-640  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-641  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-642  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-643  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-644  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-645  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-646  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-647  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-648  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-649  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-650  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-651  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-652  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-653  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-654  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-655  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-656  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-657  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-658  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-659  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-660  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-661  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-662  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-663  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-664  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-665  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-666  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-667  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-668  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-669  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-670  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-671  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-672  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-673  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-674  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-675  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-676  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-677  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-678  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-679  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-680  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-681  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-682  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-683  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-684  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-685  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-686  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-687  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-688  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-689  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-690  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-691  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-692  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-693  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-694  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-695  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-696  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-697  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-698  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-699  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-700  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-701  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-702  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-703  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-704  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-705  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-706  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-707  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-708  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-709  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-710  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-711  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-712  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-713  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-714  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-715  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-716  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-717  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-718  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-719  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-720  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-721  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-722  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-723  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-724  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-725  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-726  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-727  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-728  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-729  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-730  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-731  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-732  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-733  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-734  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-735  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-736  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-737  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-738  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-739  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-740  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-741  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-742  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-743  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-744  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-745  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-746  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-747  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-748  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-749  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-750  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-751  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-752  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-753  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-754  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-755  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-756  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-757  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-758  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-759  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-760  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-761  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-762  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-763  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-764  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-765  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-766  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-767  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-768  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-769  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-770  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-771  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-772  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-773  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-774  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-775  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-776  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-777  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-778  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-779  
                 —CH 2 —NH—CH 3   
                 —N(CH 3 )— 
               
               
                 Ia-780  
                 —CH 2 —NH—CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-781  
                 —CH 2 —NH—CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-782  
                 —CH 2 —NH—CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-783  
                 —CH 2 —NH—CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-784  
                 —CH 2 —NH—CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-785  
                 —CH 2 —NH—CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-786  
                 —CH 2 —NH—CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-787  
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 3 )— 
               
               
                 Ia-788  
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-789  
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-790  
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-791  
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-792  
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-793  
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-794  
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-795  
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 3 )— 
               
               
                 Ia-796  
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-797  
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-798  
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-799  
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-800  
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-801  
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-802  
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-803  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-804  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-805  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-806  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-807  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-808  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-809  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-810  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-811  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-812  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-813  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-814  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-815  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-816  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-817  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-818  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-819  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-820  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-821  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-822  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-823  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-824  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-825  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-826  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-827  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-828  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-829  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-830  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-831  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-832  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-833  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-834  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-835  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-836  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-837  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-838  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-839  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-840  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-841  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-842  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-843  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-844  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-845  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-846  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-847  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-848  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-849  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-850  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-851  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-852  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-853  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-854  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-855  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-856  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-857  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-858  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-859  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-860  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-861  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-862  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-863  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-864  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-865  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-866  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-867  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-868  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-869  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-870  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-871  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-872  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-873  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-874  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-875  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-876  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-877  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-878  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-879  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-880  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-881  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-882  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-883  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-884  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-885  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-886  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-887  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-888  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-889  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-890  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-891  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-892  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-893  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-894  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-895  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-896  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-897  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-898  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-899  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-900  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-901  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-902  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-903  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-904  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-905  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-906  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-907  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-908  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-909  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-910  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-911  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-912  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-913  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-914  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-915  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-916  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-917  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-918  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-919  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-920  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-921  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-922  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-923  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-924  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-925  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-926  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-927  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-928  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-929  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-930  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-931  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-932  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-933  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-934  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-935  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-936  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-937  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-938  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-939  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-940  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-941  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-942  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-943  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-944  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-945  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-946  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-947  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-948  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-949  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-950  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-951  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-952  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-953  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-954  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-955  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-956  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-957  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-958  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-959  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-960  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-961  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-962  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-963  
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 3 )— 
               
               
                 Ia-964  
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-965  
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-966  
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-967  
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-968  
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-969  
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-970  
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-971  
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 3 )— 
               
               
                 Ia-972  
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-973  
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-974  
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-975  
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-976  
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-977  
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-978  
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-979  
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 3 )— 
               
               
                 Ia-980  
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-981  
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-982  
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-983  
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-984  
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-985  
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-986  
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-987  
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 3 )— 
               
               
                 Ia-988  
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-989  
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-990  
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-991  
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-992  
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-993  
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-994  
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ia-995  
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 3 )— 
               
               
                 Ia-996  
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ia-997  
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ia-998  
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ia-999  
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ia-1000 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ia-1001 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ia-1002 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-1003 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-1004 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1005 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1006 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1007 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-1008 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1009 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1010 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-1011 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-1012 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1013 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1014 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1015 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-1016 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1017 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1018 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-1019 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-1020 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1021 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1022 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1023 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-1024 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1025 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1026 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-1027 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-1028 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1029 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1030 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1031 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-1032 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1033 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1034 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-1035 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-1036 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1037 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1038 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1039 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-1040 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1041 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1042 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-1043 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-1044 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1045 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1046 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1047 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-1048 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1049 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1050 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ia-1051 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ia-1052 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1053 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1054 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ia-1055 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ia-1056 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1057 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ia-1058 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Compound 
                 n 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ia-a1  
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a2  
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a3  
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a4  
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a5  
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a6  
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a7  
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a8  
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a9  
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a10  
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a11  
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a12  
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a13  
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a14  
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a15  
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a16  
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a17  
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a18  
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a19  
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a20  
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a21  
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a22  
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a23  
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a24  
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a25  
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a26  
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a27  
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a28  
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a29  
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a30  
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a31  
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ia-a32  
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ia-a33  
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ia-a34  
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ia-a35  
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ia-a36  
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ia-a37  
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ia-a38  
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ia-a39  
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ia-a40  
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ia-a41  
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ia-a42  
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ia-a43  
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a44  
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a45  
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a46  
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a47  
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a48  
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a49  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a50  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a51  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a52  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a53  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a54  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a55  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a56  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a57  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a58  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a59  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a60  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a61  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a62  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a63  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a64  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a65  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a66  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a67  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a68  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a69  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a70  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a71  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a72  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a73  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a74  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a75  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a76  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a77  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a78  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a79  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a80  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a81  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a82  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a83  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a84  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a85  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a86  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a87  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a88  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a89  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a90  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a91  
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a92  
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a93  
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a94  
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a95  
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a96  
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Compound 
                 m 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ia-a146 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a147 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a148 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a149 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a150 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a151 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a152 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a153 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a154 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a155 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a156 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a157 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a158 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a159 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a160 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a161 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a162 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a163 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a164 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a165 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a166 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a167 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a168 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a169 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a170 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a171 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ia-a172 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ia-a173 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ia-a174 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ia-a175 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ia-a176 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ia-a178 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ia-a179 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ia-a180 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ia-a181 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ia-a182 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a183 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a184 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a185 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a186 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a187 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a188 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a189 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a190 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a191 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a192 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a193 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a194 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a195 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a196 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a197 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a198 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a199 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a200 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a201 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a202 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a203 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a204 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a205 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a206 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a207 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a208 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a209 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a210 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a211 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a212 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a213 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a214 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a215 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a216 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a217 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a218 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a219 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a220 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a221 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a222 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a223 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a224 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a225 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a226 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Compound 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ia-a267 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a268 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a269 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a270 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a271 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a275 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a276 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a277 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a278 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a279 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a283 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —CH(OH)— 
               
               
                 Ia-a284 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a285 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a286 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a291 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a292 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a293 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a294 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a295 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a296 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a297 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a298 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ia-a299 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a300 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a301 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a302 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a303 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a304 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a305 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a306 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a307 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a308 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a309 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a310 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a311 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a312 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a313 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a314 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a315 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a316 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a317 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a318 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a319 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a320 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a321 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a322 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a323 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a324 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a325 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a326 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a327 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a328 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a329 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a330 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a331 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a332 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a333 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a334 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a335 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a336 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a337 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a338 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a339 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a340 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a341 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a342 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a343 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a344 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a345 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a346 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a347 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a348 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a349 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a350 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a351 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a352 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a353 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a354 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a355 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a356 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a357 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a358 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a359 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a360 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a361 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a362 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a363 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a364 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a365 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a366 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a367 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a368 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a369 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a370 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a371 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a372 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a373 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a374 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a375 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a376 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a377 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a378 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a379 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a380 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a381 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a382 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a383 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a384 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a385 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a386 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a387 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a388 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a389 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a390 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a391 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a392 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a393 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a394 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a395 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a396 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a397 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a398 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a399 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a400 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a401 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a402 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a403 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a404 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a405 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a406 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a407 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a408 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a409 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a410 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a411 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a412 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a413 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a414 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a415 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a416 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a417 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a418 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a419 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a420 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a421 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a422 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a423 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a424 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a425 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a426 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a427 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a428 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a429 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a430 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a431 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a432 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a433 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a434 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a435 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a436 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a437 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a438 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a439 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a440 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a441 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a442 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a443 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a444 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a445 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a446 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a447 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a448 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a449 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a450 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a451 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a452 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a453 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a454 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a455 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a456 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a457 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a458 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a459 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a460 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a461 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a462 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a463 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a464 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a465 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a466 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a467 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a468 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a469 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a470 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a471 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a472 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a473 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a474 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a475 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a476 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a477 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a478 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a479 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a480 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a481 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a482 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a483 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a484 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a485 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a486 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a487 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a488 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a489 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a490 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a491 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —CH(OH)— 
               
               
                 Ia-a492 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a493 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a494 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a495 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a496 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a497 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a498 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ia-a499 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —CH(OH)— 
               
               
                 Ia-a500 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a501 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a502 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a503 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a504 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a505 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a506 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a507 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a508 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a509 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a510 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a511 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a512 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a513 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a514 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a515 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a516 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a517 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a518 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a519 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a520 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a521 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a522 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a523 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a524 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a525 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a526 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a527 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a528 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a529 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a530 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ia-a531 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a532 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a533 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a534 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a535 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a536 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a537 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a538 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a539 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a540 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a541 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a542 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a543 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a544 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a545 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a546 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a547 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a548 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a549 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a550 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a551 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a552 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a553 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a554 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a555 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a556 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a557 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a558 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a559 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a560 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a561 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a562 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a563 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a564 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a565 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a566 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a567 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a568 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a569 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a570 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a571 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a572 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a573 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a574 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a575 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a576 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a577 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a578 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a579 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a580 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a581 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a582 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a583 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a584 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a585 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a586 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a587 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a588 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a589 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a590 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a591 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a592 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a593 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a594 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a595 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a596 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a597 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a598 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a599 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a600 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a601 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a602 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a603 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a604 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a605 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a606 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a607 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a608 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a609 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a610 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a611 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ia-a612 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a613 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a614 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a615 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a616 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a617 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a618 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a619 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a620 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a621 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a622 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a623 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a624 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a625 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a626 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a627 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a628 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a629 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a630 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a631 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a632 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a633 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a634 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a635 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a636 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a637 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a638 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a639 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a640 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a641 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a642 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a643 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a644 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a645 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a646 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a647 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a648 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a649 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a650 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a651 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a652 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a653 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a654 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a655 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a656 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a657 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a658 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a659 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a660 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a661 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a662 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a663 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a664 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a665 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a666 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a667 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a668 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a669 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a670 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a671 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a672 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a673 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a674 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a675 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a676 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a677 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a678 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a679 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a680 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a681 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a682 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a683 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a684 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a685 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a686 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a687 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a688 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a689 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a690 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a691 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a692 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a693 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a694 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a695 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a696 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a697 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a698 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a699 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a700 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a701 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a702 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a703 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a704 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a705 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a706 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a707 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a708 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a709 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a710 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a711 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a712 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a713 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a714 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a715 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a716 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a717 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a718 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a719 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a720 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a721 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a722 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a723 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a724 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a725 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a726 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a727 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a728 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a729 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a730 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a731 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a732 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a733 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a734 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a735 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a736 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a737 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a738 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a739 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a740 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a741 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a742 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a743 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a744 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a745 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a746 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a747 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a748 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a749 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a750 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a751 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a752 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a753 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a754 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a755 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a756 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a757 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a758 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a759 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a760 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a761 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a762 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a763 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a764 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a765 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a766 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a767 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a768 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a769 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a770 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a771 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a772 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a773 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a774 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a775 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a776 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a777 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a778 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a779 
                 —CH 2 —NH—CH 3   
                 —CH(OH)— 
               
               
                 Ia-a780 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a781 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a782 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a783 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a784 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a785 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a786 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ia-a787 
                 —CH 2 —NH—CH 2 —CH 3   
                 —CH(OH)— 
               
               
                 Ia-a788 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a789 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a790 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a791 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a792 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a793 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a794 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ia-a795 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —CH(OH)— 
               
               
                 Ia-a796 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a797 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a798 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a799 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a800 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a801 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a802 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a803 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a804 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a805 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a806 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a807 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a808 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a809 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a810 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a811 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a812 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a813 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a814 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a815 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a816 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a817 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a818 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a819 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a820 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a821 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a822 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a823 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a824 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a825 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a826 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a827 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a828 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a829 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a830 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a831 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a832 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a833 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a834 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a835 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a836 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a837 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a838 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a839 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a840 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a841 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a842 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a843 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a844 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a845 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a846 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a847 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a848 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a849 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a850 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a851 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a852 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a853 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a854 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a855 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a856 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a857 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a858 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a859 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a860 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a861 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a862 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a863 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a864 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a865 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a866 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a867 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a868 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a869 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a870 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a871 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a872 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a873 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a874 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a875 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a876 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a877 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a878 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a879 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a880 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a881 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a882 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a883 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a884 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a885 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a886 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a887 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a888 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a889 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a890 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a891 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a892 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a893 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a894 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a895 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a896 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a897 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a898 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a899 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a900 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a901 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a902 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a903 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a904 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a905 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a906 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a907 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a908 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a909 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a910 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a911 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a912 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a913 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a914 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a915 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a916 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a917 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a918 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a919 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a920 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a921 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a922 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a923 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a924 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a925 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a926 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a927 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a928 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a929 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a930 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a931 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a932 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a933 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a934 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a935 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a936 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a937 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a938 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a939 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a940 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a941 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a942 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a943 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a944 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a945 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a946 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a947 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a948 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a949 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a950 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a951 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a952 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a953 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a954 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a955 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a956 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a957 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a958 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a959 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a960 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a961 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a962 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a963 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —CH(OH)— 
               
               
                 Ia-a964 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a965 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a966 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a967 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a968 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a969 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a970 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ia-a971 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —CH(OH)— 
               
               
                 Ia-a972 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a973 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a974 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a975 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a976 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a977 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a978 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ia-a979 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —CH(OH)— 
               
               
                 Ia-a980 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a981 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a982 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a983 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a984 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a985 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a986 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ia-a987 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —CH(OH)— 
               
               
                 Ia-a988 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a989 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a990 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a991 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a992 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a993 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a994 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ia-a995 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —CH(OH)— 
               
               
                 Ia-a996 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ia-a997 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ia-a998 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ia-a999 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a1000 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ia-a1001 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ia-a1002 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a1003 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a1004 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a1005 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a1006 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a1007 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1008 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1009 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1010 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a1011 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a1012 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a1013 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a1014 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a1015 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1016 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1017 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1018 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a1019 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a1020 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a1021 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a1022 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a1023 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1024 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1025 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1026 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a1027 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a1028 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a1029 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a1030 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a1031 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1032 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1033 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1034 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a1035 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a1036 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a1037 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a1038 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a1039 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1040 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1041 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1042 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a1043 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a1044 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a1045 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a1046 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a1047 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1048 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1049 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1050 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ia-a1051 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ia-a1052 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ia-a1053 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ia-a1054 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ia-a1055 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1056 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1057 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ia-a1058 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
            
           
         
       
     
     and pharmaceutically acceptable salts thereof. 
     5.3 The Indenoisoquinolinone Analogs of Formula (IIa) 
     The present invention provides Indenoisoquinolinone Analogs according to Formula (Ib), below: 
                         
and pharmaceutically acceptable salts thereof,
 
wherein X and R 1  are as defined above for the Indenoisoquinolinone Analogs of Formula (Ib).
 
     In one embodiment, X is —N(CH 3 )—. In another embodiment, X is —N(CH 2 CH 3 )—. In another embodiment, X is —N(CH 2 CH 2 CH 3 )—. In another embodiment, X is —N(CH 2  CH 2 CH 2 CH 3 )—. In another embodiment, X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. In another embodiment, X is —N(C(H)(CH 3 ) 2 )—. In another embodiment, X is —N(CH 2 C(H)(CH 3 ) 2 )—. In another embodiment, X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 3 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 2 CH 3 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 2 CH 2 CH 3 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 2 CH 2 CH 2 CH 3 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(C(H)(CH 3 ) 2 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 2 C(H)(CH 3 ) 2 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 3 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 2 CH 3 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 2 CH 2 CH 3 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 2 CH 2 CH 2 CH 3 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(C(H)(CH 3 ) 2 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 2 C(H)(CH 3 ) 2 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, one R 2  is —H, and the other R 2  is —C 1 -C 6  alkyl. 
     In another embodiment, each R 2  is —C 1 -C 6  alkyl. 
     In another embodiment, each R 2  is -methyl. 
     In one embodiment, X is —CH(OH)—. 
     In another embodiment, X is —CH(OH)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —CH(OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—Z)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —Z)—. 
     In another embodiment, X is —N((CH 2 )—Z)—. 
     In another embodiment, X is —N((CH 2 ) 2 —Z)—. 
     In another embodiment, X is —N((CH 2 ) q —Z)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —Z)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 )—Z)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, Z is —CF 3 . 
     In another embodiment, Z is —F. 
     In yet another embodiment, Z is —OH. 
     In still another embodiment, Z is —O—CH 3 . 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —OH)—. 
     In another embodiment, X is —N((CH 2 ) 2 —OH)—. 
     In another embodiment, X is —N((CH 2 ) q —OH)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 ) 2 —OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—F)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—F)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —F)—. 
     In another embodiment, X is —N((CH 2 )—F)—. 
     In another embodiment, X is —N((CH 2 ) q —F)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —F)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 )—F)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)-. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OMe)-. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)- and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)- and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OMe)- and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —OMe)-. 
     In another embodiment, X is —N((CH 2 ) 2 —OMe)-. 
     In another embodiment, X is —N((CH 2 ) q —OMe)- and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —OMe)- and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 ) 2 —OMe)- and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —CF 3 )—. 
     In another embodiment, X is —N((CH 2 )—CF 3 )—. 
     In another embodiment, X is —N((CH 2 ) q —CF 3 )— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 )—CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and R 1  is —(CH 2 ) n —N(R 1 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —CF 3 )—. 
     In another embodiment, X is —N((CH 2 )—CF 3 )—. 
     In another embodiment, X is —N((CH 2 ) q —CF 3 )— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 )—CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, n is 1. 
     In another embodiment, n is 2. 
     In yet another embodiment, n is 3. 
     In a further embodiment, n is 4, 5, or 6. 
     In yet a further embodiment, n is 7, 8, or 9. 
     In still a further embodiment, n is 10. 
     In one embodiment, m is 2. 
     In another embodiment, m is 3. 
     In yet another embodiment, m is 4, 5, or 6. 
     In a further embodiment, m is 7, 8, or 9. 
     In yet a further embodiment, m is 10. 
     In one embodiment, p is 1. 
     In another embodiment, p is 2. 
     In yet another embodiment, p is an integer ranging from 2 to 5. 
     In one embodiment, q is 1. 
     In another embodiment, q is 2. 
     In yet another embodiment, q is an integer ranging from 2 to 5. 
     In various embodiments, —N(R 2 )(R 2 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In other embodiments, —N(R 2 )(R 2 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In some embodiments, —N(R 2 )(R 2 ) is 
     
       
         
         
             
             
         
       
     
     In still other embodiments, —N(R 2 )(R 2 ) is —N(CH 2 CH 3 )(CH 3 ), 
     —N(CH 2 CH 2 CH 3 )(CH 3 ), 
     —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ), 
     —NH—CH 2 CH 2 CH 2 CH 3 , or 
     —NH—CH 2 CH 2 —O—CH 3 . 
     In some embodiments, —N(R 2 )(R 2 ) is 
     
       
         
         
             
             
         
       
     
     In various embodiments, —N(Z 3 )(Z 4 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In other embodiments, —N(Z 3 )(Z 4 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In some embodiments, —N(Z 3 )(Z 4 ) is 
     
       
         
         
             
             
         
       
     
     In still other embodiments, —N(Z 3 )(Z 4 ) is —N(CH 2 CH 3 )(CH 3 ), 
     —N(CH 2 CH 2 CH 3 )(CH 3 ), 
     —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ), 
     —NH—CH 2 CH 2 CH 2 CH 3 , or 
     —NH—CH 2 CH 2 —O—CH 3 . 
     In some embodiments, —N(Z 3 )(Z 4 ) is 
     
       
         
         
             
             
         
       
     
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; 
     R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) or —O—(CH 2 ) m —N(R 2 )(R 2 ); 
     each R 2  is independently —H, —C 1 -C 6  alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —(C 1 -C 6  alkylene)-phenyl or -phenyl, each of which other than hydrogen is unsubstituted or substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH or —N(Z 3 )(Z 4 ), where Z 3  and Z 4  are independently —H, —C 1 -C 5  alkyl, or —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, each of which other than hydrogen is unsubstituted or substituted with one or more of -halo, —OH or —NH 2 ; 
     or N, Z 3  and Z 4  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one to three of —C 1 -C 5  alkyl, -phenyl, —(C 1 -C 5  alkylene)-phenyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —C 1 -C 5  alkylene-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, or —C 1 -C 10  alkyl; 
     or N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one to three of —C 1 -C 5  alkyl, -phenyl, —(C 1 -C 5  alkylene)-phenyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —(C 1 -C 5  alkylene)-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, or —C 1 -C 10  alkyl; 
     n is an integer ranging from 1 to 10; and 
     m is an integer ranging from 2 to 10. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is methyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is ethyl. 
     In yet another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is propyl. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is —C 3 -C 8  monocyclic cycloalkyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is cyclohexyl. 
     In yet another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; and R 1  is —CH 2 —N(R 2 )(R 2 ), wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; and R 1  is —CH 2 —N(R 2 )(R 2 ), wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with a hydroxyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; and R 1  is —CH 2 —N(R 2 )(R 2 ), wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with a nitrogen-containing 3- to 7-membered monocyclic heterocycle. 
     Illustrative examples of the Indenoisoquinolinone Analogs include the compounds of Formula (Ib) as set forth below: 
     
       
         
           
               
               
             
               
                   
               
             
            
               
                   
                 (Ib) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Compound 
                 n 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ib-1 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-2 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-3 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-4 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-5 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-6 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-7 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-8 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-9 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-10 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-11 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-12 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-13 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-14 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-15 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-16 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-17 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-18 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-19 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-20 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-21 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-22 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-23 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-24 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-25 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-26 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-27 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-28 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-29 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-30 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-31 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-32 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-33 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-34 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-35 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-36 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-37 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-38 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-39 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-40 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-41 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-42 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-43 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-44 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-45 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-46 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-47 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-48 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-49 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-50 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-51 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-52 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-53 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-54 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-55 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-56 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-57 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-58 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-59 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-60 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-61 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-62 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-63 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-64 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-65 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-66 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-67 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-68 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-69 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-70 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-71 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-72 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-73 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-74 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-75 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-76 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-77 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-78 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-79 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-80 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-81 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-82 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-83 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-84 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-85 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-86 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-87 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-88 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-89 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-90 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-91 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-92 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-93 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-94 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-95 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-96 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Compound 
                 m 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ib-146 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-147 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-148 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-149 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-150 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-151 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-152 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-153 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-154 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-155 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-156 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-157 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-158 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-159 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-160 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-161 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-162 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-163 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-164 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-165 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-166 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-167 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-168 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-169 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-170 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-171 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-172 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-173 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-174 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-175 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-176 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-178 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-179 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-180 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-181 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-182 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-183 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-184 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-185 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-186 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-187 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-188 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-189 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-190 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-191 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-192 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-193 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-194 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-195 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-196 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-197 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-198 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-199 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-200 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-201 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-202 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-203 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-204 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-205 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-206 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-207 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-208 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-209 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-210 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-211 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-212 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-213 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-214 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-215 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-216 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-217 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-218 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-219 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-220 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-221 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-222 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-223 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-224 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-225 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-226 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Compound 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ib-267 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-268 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-269 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-270 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-271 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-272 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-273 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-274 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-275 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-276 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-277 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-278 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-279 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-280 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-281 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-282 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-283 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 3 )— 
               
               
                 Ib-284 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-285 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-286 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-287 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-288 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-289 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-290 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-291 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-292 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-293 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-294 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-295 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-296 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-297 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-298 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-299 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 N(CH 3 ) 2 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-300 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-301 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-302 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-303 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 N(CH 3 ) 2 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-304 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 N(CH 3 ) 2 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-305 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 N(CH 3 ) 2 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-306 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 N(CH 3 ) 2 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-307 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-308 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-309 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-310 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-311 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-312 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-313 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-314 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-315 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-316 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-317 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-318 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-319 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-320 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-321 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-322 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-323 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-324 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-325 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-326 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-327 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-328 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-329 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-330 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-331 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-332 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-333 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-334 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-335 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-336 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-337 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-338 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-339 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-340 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-341 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-342 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-343 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-344 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-345 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-346 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-347 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-348 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-349 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-350 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-351 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-352 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-353 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-354 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-355 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-356 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-357 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-358 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-359 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-360 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-361 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-362 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-363 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-364 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-365 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-366 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-367 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-368 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-369 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-370 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-371 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-372 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-373 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-374 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-375 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-376 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-377 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-378 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-379 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-380 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-381 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-382 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-383 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-384 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-385 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-386 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-387 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-388 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-389 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-390 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-391 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-392 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-393 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-394 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-395 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-396 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-397 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-398 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-399 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-400 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-401 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-402 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-403 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-404 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-405 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-406 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-407 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-408 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-409 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-410 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-411 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-412 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-413 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-414 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-415 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-416 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-417 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-418 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-419 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-420 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-421 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-422 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-423 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-424 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-425 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-426 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-427 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-428 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-429 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-430 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-431 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-432 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-433 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-434 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-435 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-436 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-437 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-438 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-439 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-440 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-441 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-442 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-443 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-444 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-445 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-446 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-447 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-448 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-449 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-450 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-451 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-452 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-453 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-454 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-455 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-456 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-457 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-458 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-459 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-460 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-461 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-462 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-463 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-464 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-465 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-466 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-467 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-468 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-469 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-470 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-471 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-472 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-473 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-474 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-475 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-476 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-477 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-478 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-479 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-480 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-481 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-482 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-483 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-484 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-485 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-486 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-487 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-488 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-489 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-490 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-491 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 3 )— 
               
               
                 Ib-492 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-493 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-494 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-495 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-496 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-497 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-498 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-499 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 3 )— 
               
               
                 Ib-500 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-501 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-502 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-503 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-504 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-505 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-506 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-507 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-508 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-509 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-510 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-511 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-512 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-513 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-514 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-515 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-516 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-517 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-518 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-519 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-520 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-521 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-522 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-523 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-524 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-525 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-526 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-527 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-528 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-529 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-530 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-531 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-532 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-533 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-534 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-535 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-536 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-537 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-538 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-539 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-540 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-541 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-542 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-543 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-544 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-545 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-546 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-547 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-548 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-549 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-550 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-551 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-552 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-553 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-554 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-555 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-556 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-557 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-558 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-559 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-560 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-561 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-562 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-563 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-564 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-565 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-566 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-567 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-568 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-569 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-570 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-571 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-572 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-573 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-574 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-575 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-576 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-577 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-578 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-579 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-580 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-581 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-582 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-583 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-584 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-585 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-586 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-587 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-588 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-589 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-590 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-591 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-592 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-593 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-594 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-595 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-596 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-597 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-598 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-599 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-600 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-601 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-602 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-603 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-604 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-605 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-606 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-607 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-608 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-609 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-610 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-611 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ib-612 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-613 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-614 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-615 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-616 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-617 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-618 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-619 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-620 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-621 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-622 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-623 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-624 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-625 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-626 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-627 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-628 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-629 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-630 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-631 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-632 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-633 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-634 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-635 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-636 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-637 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-638 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-639 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-640 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-641 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-642 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-643 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-644 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-645 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-646 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-647 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-648 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-649 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-650 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-651 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-652 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-653 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-654 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-655 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-656 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-657 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-658 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-659 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-660 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-661 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-662 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-663 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-664 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-665 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-666 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-667 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-668 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-669 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-670 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-671 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-672 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-673 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-674 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-675 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-676 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-677 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-678 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-679 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-680 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-681 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-682 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-683 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-684 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-685 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-686 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-687 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-688 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-689 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-690 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-691 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-692 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-693 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-694 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-695 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-696 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-697 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-698 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-699 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-700 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-701 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-702 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-703 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-704 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-705 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-706 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-707 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-708 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-709 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-710 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-711 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-712 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-713 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-714 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-715 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-716 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-717 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-718 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-719 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-720 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-721 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-722 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-723 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-724 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-725 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-726 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-727 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-728 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-729 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-730 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-731 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-732 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-733 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-734 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-735 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-736 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-737 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-738 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-739 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-740 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-741 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-742 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-743 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-744 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-745 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-746 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-747 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-748 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-749 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-750 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-751 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-752 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-753 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-754 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-755 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-756 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-757 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-758 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-759 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-760 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-761 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-762 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-763 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-764 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-765 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-766 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-767 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-768 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-769 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-770 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-771 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-772 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-773 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-774 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-775 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-776 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-777 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-778 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-779 
                 —CH 2 —NH—CH 3   
                 —N(CH 3 )— 
               
               
                 Ib-780 
                 —CH 2 —NH—CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-781 
                 —CH 2 —NH—CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-782 
                 —CH 2 —NH—CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-783 
                 —CH 2 —NH—CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-784 
                 —CH 2 —NH—CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-785 
                 —CH 2 —NH—CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-786 
                 —CH 2 —NH—CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-787 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 3 )— 
               
               
                 Ib-788 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-789 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-790 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-791 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-792 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-793 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-794 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-795 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 3 )— 
               
               
                 Ib-796 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-797 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-798 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-799 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-800 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-801 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-802 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-803 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-804 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-805 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-806 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-807 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-808 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-809 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-810 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-811 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-812 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-813 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-814 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-815 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-816 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-817 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-818 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-819 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-820 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-821 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-822 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-823 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-824 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-825 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-826 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-827 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-828 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-829 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-830 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-831 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-832 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-833 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-834 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-835 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-836 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-837 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-838 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-839 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-840 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-841 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-842 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-843 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-844 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-845 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-846 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-847 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-848 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-849 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-850 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-851 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-852 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-853 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-854 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-855 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-856 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-857 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-858 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-859 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-860 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-861 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-862 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-863 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-864 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-865 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-866 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-867 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-868 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-869 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-870 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-871 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-872 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-873 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-874 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-875 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-876 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-877 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-878 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-879 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-880 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-881 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-882 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-883 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-884 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-885 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-886 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-887 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-888 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-889 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-890 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-891 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-892 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-893 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-894 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-895 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-896 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-897 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-898 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-899 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-900 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-901 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-902 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-903 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-904 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-905 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-906 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-907 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-908 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-909 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-910 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-911 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-912 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-913 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-914 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-915 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-916 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-917 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-918 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-919 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-920 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-921 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-922 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-923 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-924 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-925 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-926 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-927 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-928 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-929 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-930 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-931 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-932 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-933 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-934 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-935 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-936 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-937 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-938 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-939 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-940 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-941 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-942 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-943 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-944 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-945 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-946 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-947 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-948 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-949 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-950 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-951 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-952 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-953 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-954 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-955 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-956 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-957 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-958 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-959 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-960 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-961 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-962 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-963 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 3 )— 
               
               
                 Ib-964 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-965 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-966 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-967 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-968 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-969 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-970 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-971 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 3 )— 
               
               
                 Ib-972 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-973 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-974 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-975 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-976 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-977 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-978 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-979 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 3 )— 
               
               
                 Ib-980 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-981 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-982 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-983 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-984 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-985 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-986 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-987 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 3 )— 
               
               
                 Ib-988 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-989 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-990 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-991 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-992 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-993 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-994 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ib-995 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 3 )— 
               
               
                 Ib-996 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ib-997 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ib-998 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ib-999 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ib-1000 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ib-1001 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ib-1002 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-1003 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-1004 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1005 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1006 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1007 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-1008 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1009 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1010 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-1011 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-1012 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1013 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1014 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1015 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-1016 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1017 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1018 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-1019 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-1020 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1021 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1022 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1023 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-1024 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1025 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1026 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-1027 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-1028 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1029 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1030 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1031 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-1032 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1033 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1034 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-1035 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-1036 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1037 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1038 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1039 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-1040 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1041 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1042 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-1043 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-1044 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1045 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1046 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1047 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-1048 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1049 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1050 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ib-1051 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ib-1052 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1053 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1054 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ib-1055 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ib-1056 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1057 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ib-1058 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Compound 
                 n 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ib-b1 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b2 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b3 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b4 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b5 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b6 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b7 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b8 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b9 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b10 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b11 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b12 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b13 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b14 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b15 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b16 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b17 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b18 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b19 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b20 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b21 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b22 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b23 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b24 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b25 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b26 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b27 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b28 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b29 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b30 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b31 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ib-b32 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ib-b33 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ib-b34 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ib-b35 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ib-b36 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ib-b37 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ib-b38 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ib-b39 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ib-b40 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ib-b41 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ib-b42 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ib-b43 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b44 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b45 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b46 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b47 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b48 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b49 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b50 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b51 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b52 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b53 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b54 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b55 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b56 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b57 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b58 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b59 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b60 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b61 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b62 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b63 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b64 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b65 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b66 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b67 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b68 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b69 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b70 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b71 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b72 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b73 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b74 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b75 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b76 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b77 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b78 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b79 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b80 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b81 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b82 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b83 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b84 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b85 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b86 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b87 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b88 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b89 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b90 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b91 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b92 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b93 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b94 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b95 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b96 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Compound 
                 m 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ib-b146 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b147 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b148 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b149 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b150 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b151 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b152 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b153 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b154 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b155 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b156 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b157 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b158 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b159 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b160 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b161 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b162 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b163 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b164 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b165 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b166 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b167 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b168 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b169 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b170 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b171 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ib-b172 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ib-b173 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ib-b174 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ib-b175 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ib-b176 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ib-b178 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ib-b179 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ib-b180 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ib-b181 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ib-b182 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b183 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b184 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b185 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b186 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b187 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b188 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b189 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b190 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b191 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b192 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b193 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b194 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b195 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b196 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b197 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b198 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b199 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b200 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b201 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b202 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b203 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b204 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b205 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b206 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b207 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b208 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b209 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b210 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b211 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b212 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b213 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b214 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b215 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b216 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b217 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b218 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b219 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b220 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b221 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b222 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b223 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b224 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b225 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b226 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Compound 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ib-b267 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b268 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b269 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b270 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b271 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b275 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b276 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b277 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b278 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b279 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b283 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —CH(OH)— 
               
               
                 Ib-b284 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b285 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b286 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b291 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b292 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b293 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b294 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b295 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b296 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b297 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b298 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ib-b299 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b300 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b301 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b302 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b303 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b304 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b305 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b306 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b307 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b308 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b309 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b310 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b311 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b312 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b313 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b314 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b315 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b316 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b317 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b318 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b319 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b320 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b321 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b322 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b323 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b324 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b325 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b326 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b327 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b328 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b329 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b330 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b331 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b332 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b333 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b334 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b335 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b336 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b337 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b338 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b339 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b340 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b341 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b342 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b343 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b344 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b345 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b346 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b347 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b348 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b349 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b350 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b351 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b352 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b353 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b354 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b355 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b356 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b357 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b358 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b359 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b360 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b361 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b362 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b363 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b364 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b365 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b366 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b367 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b368 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b369 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b370 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b371 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b372 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b373 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b374 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b375 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b376 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b377 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b378 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b379 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b380 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b381 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b382 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b383 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b384 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b385 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b386 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b387 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b388 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b389 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b390 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b391 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b392 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b393 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b394 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b395 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b396 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b397 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b398 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b399 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b400 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b401 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b402 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b403 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b404 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b405 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b406 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b407 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b408 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b409 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b410 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b411 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b412 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b413 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b414 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b415 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b416 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b417 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b418 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b419 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b420 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b421 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b422 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b423 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b424 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b425 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b426 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b427 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b428 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b429 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b430 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b431 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b432 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b433 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b434 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b435 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b436 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b437 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b438 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b439 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b440 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b441 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b442 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b443 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b444 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b445 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b446 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b447 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b448 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b449 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b450 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b451 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b452 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b453 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b454 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b455 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b456 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b457 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b458 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b459 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b460 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b461 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b462 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b463 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b464 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b465 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b466 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b467 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b468 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b469 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b470 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b471 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b472 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b473 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b474 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b475 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b476 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b477 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b478 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b479 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b480 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b481 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b482 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b483 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b484 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b485 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b486 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b487 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b488 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b489 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b490 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b491 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —CH(OH)— 
               
               
                 Ib-b492 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b493 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b494 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b495 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b496 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b497 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b498 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ib-b499 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —CH(OH)— 
               
               
                 Ib-b500 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b501 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b502 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b503 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b504 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b505 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b506 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b507 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b508 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b509 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b510 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b511 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b512 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b513 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b514 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b515 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b516 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b517 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b518 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b519 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b520 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b521 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b522 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b523 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b524 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b525 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b526 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b527 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b528 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b529 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b530 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ib-b531 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b532 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b533 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b534 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b535 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b536 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b537 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b538 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b539 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b540 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b541 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b542 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b543 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b544 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b545 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b546 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b547 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b548 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b549 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b550 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b551 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b552 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b553 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b554 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b555 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b556 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b557 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b558 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b559 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b560 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b561 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b562 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b563 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b564 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b565 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b566 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b567 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b568 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b569 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b570 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b571 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b572 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b573 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b574 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b575 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b576 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b577 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b578 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b579 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b580 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b581 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b582 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b583 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b584 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b585 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b586 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b587 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b588 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b589 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b590 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b591 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b592 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b593 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b594 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b595 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b596 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b597 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b598 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b599 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b600 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b601 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b602 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b603 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b604 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b605 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b606 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b607 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b608 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b609 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b610 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b611 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ib-b612 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b613 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b614 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b615 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b616 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b617 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b618 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b619 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b620 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b621 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b622 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b623 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b624 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b625 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b626 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b627 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b628 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b629 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b630 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b631 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b632 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b633 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b634 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b635 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b636 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b637 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b638 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b639 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b640 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b641 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b642 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b643 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b644 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b645 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b646 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b647 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b648 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b649 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b650 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b651 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b652 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b653 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b654 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b655 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b656 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b657 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b658 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b659 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b660 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b661 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b662 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b663 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b664 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b665 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b666 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b667 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b668 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b669 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b670 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b671 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b672 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b673 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b674 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b675 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b676 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b677 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b678 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b679 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b680 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b681 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b682 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b683 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b684 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b685 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b686 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b687 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b688 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b689 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b690 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b691 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b692 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b693 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b694 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b695 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b696 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b697 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b698 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b699 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b700 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b701 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b702 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b703 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b704 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b705 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b706 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b707 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b708 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b709 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b710 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b711 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b712 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b713 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b714 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b715 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b716 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b717 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b718 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b719 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b720 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b721 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b722 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b723 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b724 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b725 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b726 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b727 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b728 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b729 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b730 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b731 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b732 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b733 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b734 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b735 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b736 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b737 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b738 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b739 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b740 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b741 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b742 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b743 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b744 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b745 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b746 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b747 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b748 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b749 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b750 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b751 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b752 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b753 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b754 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b755 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b756 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b757 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b758 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b759 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b760 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b761 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b762 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b763 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b764 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b765 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b766 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b767 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b768 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b769 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b770 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b771 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b772 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b773 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b774 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b775 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b776 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b777 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b778 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b779 
                 —CH 2 —NH—CH 3   
                 —CH(OH)— 
               
               
                 Ib-b780 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b781 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b782 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b783 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b784 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b785 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b786 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ib-b787 
                 —CH 2 —NH—CH 2 —CH 3   
                 —CH(OH)— 
               
               
                 Ib-b788 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b789 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b790 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b791 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b792 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b793 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b794 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ib-b795 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —CH(OH)— 
               
               
                 Ib-b796 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b797 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b798 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b799 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b800 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b801 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b802 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b803 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b804 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b805 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b806 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b807 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b808 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b809 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b810 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b811 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b812 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b813 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b814 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b815 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b816 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b817 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b818 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b819 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b820 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b821 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b822 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b823 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b824 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b825 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b826 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b827 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b828 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b829 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b830 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b831 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b832 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b833 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b834 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b835 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b836 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b837 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b838 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b839 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b840 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b841 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b842 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b843 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b844 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b845 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b846 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b847 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b848 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b849 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b850 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b851 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b852 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b853 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b854 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b855 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b856 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b857 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b858 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b859 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b860 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b861 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b862 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b863 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b864 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b865 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b866 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b867 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b868 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b869 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b870 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b871 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b872 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b873 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b874 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b875 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b876 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b877 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b878 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b879 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b880 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b881 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b882 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b883 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b884 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b885 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b886 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b887 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b888 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b889 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b890 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b891 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b892 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b893 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b894 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b895 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b896 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b897 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b898 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b899 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b900 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b901 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b902 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b903 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b904 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b905 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b906 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b907 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b908 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b909 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b910 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b911 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b912 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b913 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b914 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b915 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b916 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b917 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b918 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b919 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b920 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b921 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b922 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b923 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b924 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b925 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b926 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b927 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b928 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b929 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b930 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b931 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b932 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b933 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b934 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b935 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b936 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b937 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b938 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b939 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b940 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b941 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b942 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b943 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b944 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b945 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b946 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b947 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b948 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b949 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b950 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b951 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b952 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b953 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b954 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b955 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b956 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b957 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b958 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b959 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b960 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b961 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b962 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b963 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —CH(OH)— 
               
               
                 Ib-b964 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b965 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b966 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b967 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b968 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b969 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b970 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ib-b971 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —CH(OH)— 
               
               
                 Ib-b972 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b973 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b974 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b975 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b976 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b977 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b978 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ib-b979 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —CH(OH)— 
               
               
                 Ib-b980 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b981 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b982 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b983 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b984 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b985 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b986 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ib-b987 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —CH(OH)— 
               
               
                 Ib-b988 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b989 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b990 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b991 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b992 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b993 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b994 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ib-b995 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —CH(OH)— 
               
               
                 Ib-b996 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ib-b997 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ib-b998 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ib-b999 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b1000 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ib-b1001 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ib-b1002 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b1003 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b1004 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b1005 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b1006 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b1007 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1008 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1009 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1010 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b1011 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b1012 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b1013 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b1014 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b1015 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1016 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1017 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1018 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b1019 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b1020 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b1021 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b1022 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b1023 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1024 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1025 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1026 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b1027 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b1028 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b1029 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b1030 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b1031 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1032 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1033 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1034 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b1035 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b1036 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b1037 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b1038 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b1039 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1040 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1041 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1042 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b1043 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b1044 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b1045 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b1046 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b1047 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1048 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1049 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1050 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ib-b1051 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ib-b1052 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ib-b1053 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ib-b1054 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ib-b1055 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1056 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1057 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ib-b1058 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
            
           
         
       
     
     and pharmaceutically acceptable salts thereof. 
     5.4 The Indenoisoquinolinone Analogs of Formula (Ic) 
     The present invention provides Indenoisoquinolinone Analogs according to Formula (Ic), below: 
                         
and pharmaceutically acceptable salts thereof,
 
wherein X and R 1  are as defined above for the Indenoisoquinolinone Analogs of Formula (Ic).
 
     In one embodiment, X is —N(CH 3 )—. In another embodiment, X is —N(CH 2 CH 3 )—. In another embodiment, X is —N(CH 2 CH 2 CH 3 )—. In another embodiment, X is —N(CH 2  CH 2 CH 2 CH 3 )—. In another embodiment, X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. In another embodiment, X is —N(C(H)(CH 3 ) 2 )—. In another embodiment, X is —N(CH 2 C(H)(CH 3 ) 2 )—. In another embodiment, X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 3 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 2 CH 3 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 2 CH 2 CH 3 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 2 CH 2 CH 2 CH 3 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(C(H)(CH 3 ) 2 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(CH 2 C(H)(CH 3 ) 2 )—. 
     In another embodiment, R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) and X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 3 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 2 CH 3 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 2 CH 2 CH 3 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 2 CH 2 CH 2 CH 3 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(C(H)(CH 3 ) 2 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(CH 2 C(H)(CH 3 ) 2 )—. 
     In another embodiment, R 1  is —O—(CH 2 ) m —N(R 2 )(R 2 ) and X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, one R 2  is —H, and the other R 2  is —C 1 -C 6  alkyl. 
     In another embodiment, each R 2  is —C 1 -C 6  alkyl. 
     In another embodiment, each R 2  is -methyl. 
     In one embodiment, X is —CH(OH)—. 
     In another embodiment, X is —CH(OH)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —CH(OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—Z)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —Z)—. 
     In another embodiment, X is —N((CH 2 )—Z)—. 
     In another embodiment, X is —N((CH 2 ) 2 —Z)—. 
     In another embodiment, X is —N((CH 2 ) q —Z)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —Z)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 )—Z)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, Z is —CF 3 . 
     In another embodiment, Z is —F. 
     In yet another embodiment, Z is —OH. 
     In still another embodiment, Z is —O—CH 3 . 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —OH)—. 
     In another embodiment, X is —N((CH 2 ) 2 —OH)—. 
     In another embodiment, X is —N((CH 2 ) q —OH)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 ) 2 —OH)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—F)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—F)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —F)—. 
     In another embodiment, X is —N((CH 2 )—F)—. 
     In another embodiment, X is —N((CH 2 ) q —F)— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —F)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 )—F)— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)-. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OMe)-. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)- and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)- and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OMe)- and R 1  is —(CH 2 )— N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —OMe)-. 
     In another embodiment, X is —N((CH 2 ) 2 —OMe)-. 
     In another embodiment, X is —N((CH 2 ) q —OMe)- and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —OMe)- and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 ) 2 —OMe)- and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —CF 3 )—. 
     In another embodiment, X is —N((CH 2 )—CF 3 )—. 
     In another embodiment, X is —N((CH 2 ) q —CF 3 )— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 )—CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, X is —N((CH 2 ) q —CF 3 )—. 
     In another embodiment, X is —N((CH 2 )—CF 3 )—. 
     In another embodiment, X is —N((CH 2 ) q —CF 3 )— and R 1  is —(CH 2 ) n —N(R 2 )(R 2 ). 
     In yet another embodiment, X is —N((CH 2 ) q —CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In still another embodiment, X is —N((CH 2 )—CF 3 )— and R 1  is —(CH 2 )—N(R 2 )(R 2 ). 
     In one embodiment, n is 1. 
     In another embodiment, n is 2. 
     In yet another embodiment, n is 3. 
     In a further embodiment, n is 4, 5, or 6. 
     In yet a further embodiment, n is 7, 8, or 9. 
     In still a further embodiment, n is 10. 
     In one embodiment, m is 2. 
     In another embodiment, m is 3. 
     In yet another embodiment, m is 4, 5, or 6. 
     In a further embodiment, m is 7, 8, or 9. 
     In yet a further embodiment, m is 10. 
     In one embodiment, p is 1. 
     In another embodiment, p is 2. 
     In yet another embodiment, p is an integer ranging from 2 to 5. 
     In one embodiment, q is 1. 
     In another embodiment, q is 2. 
     In yet another embodiment, q is an integer ranging from 2 to 5. 
     In various embodiments, —N(R 2 )(R 2 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In other embodiments, —N(R 2 )(R 2 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In some embodiments, —N(R 2 )(R 2 ) is 
     
       
         
         
             
             
         
       
     
     In still other embodiments, —N(R 2 )(R 2 ) is —N(CH 2 CH 3 )(CH 3 ), 
     —N(CH 2 CH 2 CH 3 )(CH 3 ), 
     —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ), 
     —NH—CH 2 CH 2 CH 2 CH 3 , or 
     —NH—CH 2 CH 2 —O—CH 3 . 
     In some embodiments, —N(R 2 )(R 2 ) is 
     
       
         
         
             
             
         
       
     
     In various embodiments, —N(Z 3 )(Z 4 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In other embodiments, —N(Z 3 )(Z 4 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In some embodiments, —N(Z 3 )(Z 4 ) is 
     
       
         
         
             
             
         
       
     
     In still other embodiments, —N(Z 3 )(Z 4 ) is
         —N(CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ),   —NH—CH 2 CH 2 CH 2 CH 3 , or   —NH—CH 2 CH 2 —O—CH 3 .       

     In some embodiments, —N(Z 3 )(Z 4 ) is 
     
       
         
         
             
             
         
       
     
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; 
     R 1  is —(CH 2 ) n —N(R 2 )(R 2 ) or —O—(CH 2 ) m —N(R 2 )(R 2 ); 
     each R 2  is independently —H, —C 1 -C 6  alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —(C 1 -C 6  alkylene)-phenyl or -phenyl, each of which other than hydrogen is unsubstituted or substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH or —N(Z 3 )(Z 4 ), where Z 3  and Z 4  are independently —H, —C 1 -C 5  alkyl, or —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, each of which other than hydrogen is unsubstituted or substituted with one or more of -halo, —OH or —NH 2 ; 
     or N, Z 3  and Z 4  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one to three of —C 1 -C 5  alkyl, -phenyl, —(C 1 -C 5  alkylene)-phenyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —C 1 -C 5  alkylene-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, or —C 1 -C 10  alkyl; 
     or N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one to three of —C 1 -C 5  alkyl, -phenyl, —(C 1 -C 5  alkylene)-phenyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —(C 1 -C 5  alkylene)-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, or —C 1 -C 10  alkyl; 
     n is an integer ranging from 1 to 10; and 
     m is an integer ranging from 2 to 10. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is methyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is ethyl. 
     In yet another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is propyl. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is —C 3 -C 8  monocyclic cycloalkyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; R 1  is —CH 2 —N(R 2 )(R 2 ); and at least one R 2  is cyclohexyl. 
     In yet another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; and R 1  is —CH 2 —N(R 2 )(R 2 ), wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; and R 1  is —CH 2 —N(R 2 )(R 2 ), wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with a hydroxyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; and R 1  is —CH 2 —N(R 2 )(R 2 ), wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with a nitrogen-containing 3- to 7-membered monocyclic heterocycle. 
     Illustrative examples of the Indenoisoquinolinone Analogs include the compounds of Formula (Ic) as set forth below: 
     
       
         
           
               
               
             
               
                   
               
             
            
               
                   
                 (Ic) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Compound 
                 n 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ic-1 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-2 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-3 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-4 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-5 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-6 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-7 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-8 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-9 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-10 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-11 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-12 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-13 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-14 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-15 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-16 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-17 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-18 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-19 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-20 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-21 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-22 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-23 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-24 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-25 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-26 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-27 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-28 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-29 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-30 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-31 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-32 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-33 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-34 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-35 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-36 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-37 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-38 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-39 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-40 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-41 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-42 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-43 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-44 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-45 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-46 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-47 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-48 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-49 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-50 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-51 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-52 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-53 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-54 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-55 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-56 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-57 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-58 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-59 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-60 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-61 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-62 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-63 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-64 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-65 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-66 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-67 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-68 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-69 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-70 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-71 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-72 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-73 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-74 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-75 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-76 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-77 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-78 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-79 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-80 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-81 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-82 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-83 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-84 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-85 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-86 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-87 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-88 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-89 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-90 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-91 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-92 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-93 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-94 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-95 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-96 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Compound 
                 m 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ic-146 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-147 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-148 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-149 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-150 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-151 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-152 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-153 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-154 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-155 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-156 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-157 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-158 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-159 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-160 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-161 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-162 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-163 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-164 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-165 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-166 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-167 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-168 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-169 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-170 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-171 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-172 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-173 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-174 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-175 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-176 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-178 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-179 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-180 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-181 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-182 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-183 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-184 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-185 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-186 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-187 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-188 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-189 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-190 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-191 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-192 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-193 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-194 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-195 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-196 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-197 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-198 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-199 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-200 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-201 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-202 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-203 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-204 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-205 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-206 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-207 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-208 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-209 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-210 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-211 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-212 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-213 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-214 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-215 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-216 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-217 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-218 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-219 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-220 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-221 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-222 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-223 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-224 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-225 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-226 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Compound 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ic-267 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-268 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-269 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-270 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-271 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-272 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-273 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-274 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-275 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-276 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-277 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-278 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-279 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-280 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-281 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-282 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-283 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 3 )— 
               
               
                 Ic-284 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-285 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-286 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-287 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-288 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-289 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-290 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-291 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-292 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-293 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-294 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-295 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-296 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-297 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-298 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-299 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-300 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-301 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-302 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-303 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-304 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-305 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-306 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-307 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-308 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-309 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-310 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-311 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-312 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-313 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-314 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-315 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-316 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-317 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-318 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-319 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-320 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-321 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-322 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-323 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-324 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-325 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-326 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-327 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-328 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-329 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-330 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-331 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-332 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-333 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-334 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-335 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-336 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-337 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-338 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-339 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-340 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-341 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-342 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-343 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-344 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-345 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-346 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-347 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-348 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-349 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-350 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-351 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-352 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-353 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-354 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-355 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-356 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-357 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-358 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-359 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-360 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-361 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-362 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-363 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-364 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-365 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-366 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-367 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-368 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-369 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-370 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-371 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-372 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-373 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-374 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-375 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-376 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-377 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-378 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-379 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-380 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-381 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-382 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-383 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-384 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-385 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-386 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-387 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-388 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-389 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-390 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-391 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-392 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-393 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-394 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-395 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-396 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-397 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-398 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-399 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-400 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-401 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-402 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-403 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-404 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-405 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-406 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-407 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-408 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-409 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-410 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-411 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-412 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-413 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-414 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-415 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-416 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-417 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-418 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-419 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-420 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-421 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-422 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-423 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-424 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-425 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-426 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-427 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-428 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-429 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-430 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-431 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-432 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-433 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-434 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-435 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-436 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-437 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-438 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-439 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-440 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-441 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-442 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-443 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-444 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-445 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-446 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-447 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-448 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-449 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-450 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-451 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-452 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-453 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-454 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-455 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-456 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-457 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-458 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-459 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-460 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-461 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-462 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-463 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-464 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-465 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-466 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-467 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-468 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-469 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-470 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-471 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-472 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-473 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-474 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-475 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-476 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-477 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-478 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-479 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-480 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-481 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-482 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-483 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-484 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-485 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-486 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-487 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-488 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-489 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-490 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-491 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 3 )— 
               
               
                 Ic-492 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-493 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-494 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-495 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-496 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-497 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-498 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-499 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 3 )— 
               
               
                 Ic-500 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-501 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-502 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-503 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-504 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-505 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-506 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-507 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-508 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-509 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-510 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-511 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-512 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-513 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-514 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-515 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-516 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-517 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-518 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-519 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-520 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-521 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-522 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-523 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-524 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-525 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-526 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-527 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-528 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-529 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-530 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-531 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-532 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-533 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-534 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-535 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-536 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-537 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-538 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-539 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-540 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-541 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-542 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-543 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-544 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-545 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-546 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-547 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-548 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-549 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-550 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-551 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-552 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-553 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-554 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-555 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-556 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-557 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-558 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-559 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-560 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-561 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-562 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-563 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-564 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-565 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-566 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-567 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-568 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-569 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-570 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-571 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-572 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-573 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-574 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-575 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-576 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-577 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-578 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-579 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-580 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-581 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-582 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-583 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-584 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-585 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-586 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-587 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-588 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-589 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-590 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-591 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-592 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-593 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-594 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-595 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-596 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-597 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-598 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-599 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-600 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-601 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-602 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-603 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-604 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-605 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-606 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-607 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-608 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-609 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-610 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-611 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 3 )— 
               
               
                 Ic-612 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-613 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-614 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-615 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-616 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-617 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-618 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-619 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-620 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-621 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-622 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-623 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-624 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-625 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-626 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-627 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-628 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-629 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-630 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-631 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-632 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-633 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-634 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-635 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-636 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-637 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-638 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-639 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-640 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-641 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-642 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-643 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-644 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-645 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-646 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-647 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-648 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-649 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-650 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-651 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-652 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-653 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-654 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-655 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-656 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-657 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-658 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-659 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-660 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-661 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-662 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-663 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-664 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-665 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-666 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-667 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-668 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-669 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-670 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-671 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-672 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-673 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-674 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-675 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-676 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-677 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-678 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-679 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-680 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-681 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-682 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-683 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-684 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-685 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-686 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-687 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-688 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-689 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-690 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-691 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-692 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-693 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-694 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-695 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-696 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-697 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-698 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-699 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-700 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-701 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-702 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-703 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-704 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-705 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-706 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-707 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-708 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-709 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-710 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-711 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-712 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-713 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-714 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-715 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-716 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-717 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-718 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-719 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-720 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-721 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-722 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-723 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-724 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-725 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-726 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-727 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-728 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-729 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-730 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-731 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-732 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-733 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-734 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-735 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-736 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-737 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-738 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-739 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-740 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-741 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-742 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-743 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-744 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-745 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-746 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-747 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-748 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-749 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-750 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-751 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-752 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-753 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-754 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-755 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-756 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-757 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-758 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-759 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-760 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-761 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-762 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-763 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-764 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-765 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-766 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-767 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-768 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-769 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-770 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-771 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-772 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-773 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-774 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-775 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-776 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-777 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-778 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-779 
                 —CH 2 —NH—CH 3   
                 —N(CH 3 )— 
               
               
                 Ic-780 
                 —CH 2 —NH—CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-781 
                 —CH 2 —NH—CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-782 
                 —CH 2 —NH—CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-783 
                 —CH 2 —NH—CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-784 
                 —CH 2 —NH—CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-785 
                 —CH 2 —NH—CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-786 
                 —CH 2 —NH—CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-787 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 3 )— 
               
               
                 Ic-788 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-789 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-790 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-791 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-792 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-793 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-794 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-795 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 3 )— 
               
               
                 Ic-796 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-797 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-798 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-799 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-800 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-801 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-802 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-803 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-804 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-805 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-806 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-807 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-808 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-809 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-810 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-811 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-812 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-813 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-814 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-815 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-816 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-817 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-818 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-819 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-820 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-821 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-822 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-823 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-824 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-825 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-826 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-827 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-828 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-829 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-830 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-831 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-832 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-833 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-834 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-835 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-836 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-837 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-838 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-839 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-840 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-841 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-842 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-843 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-844 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-845 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-846 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-847 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-848 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-849 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-850 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-851 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-852 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-853 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-854 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-855 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-856 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-857 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-858 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-859 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-860 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-861 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-862 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-863 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-864 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-865 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-866 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-867 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-868 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-869 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-870 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-871 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-872 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-873 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-874 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-875 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-876 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-877 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-878 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-879 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-880 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-881 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-882 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-883 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-884 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-885 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-886 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-887 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-888 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-889 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-890 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-891 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-892 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-893 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-894 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-895 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-896 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-897 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-898 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-899 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-900 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-901 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-902 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-903 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-904 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-905 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-906 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-907 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-908 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-909 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-910 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-911 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-912 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-913 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-914 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-915 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-916 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-917 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-918 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-919 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-920 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-921 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-922 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-923 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-924 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-925 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-926 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-927 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-928 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-929 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-930 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-931 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-932 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-933 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-934 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-935 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-936 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-937 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-938 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-939 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-940 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-941 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-942 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-943 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-944 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-945 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-946 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-947 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-948 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-949 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-950 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-951 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-952 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-953 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-954 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-955 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-956 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-957 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-958 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-959 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-960 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-961 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-962 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-963 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 3 )— 
               
               
                 Ic-964 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-965 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-966 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-967 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-968 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-969 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-970 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-971 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 3 )— 
               
               
                 Ic-972 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-973 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-974 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-975 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-976 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-977 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-978 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-979 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 3 )— 
               
               
                 Ic-980 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-981 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-982 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-983 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-984 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-985 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-986 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-987 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 3 )— 
               
               
                 Ic-988 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-989 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-990 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-991 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-992 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-993 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-994 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                 Ic-995 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 3 )— 
               
               
                 Ic-996 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 2 CH 3 )— 
               
               
                 Ic-997 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 Ic-998 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 Ic-999 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 Ic-1000 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 Ic-1001 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 Ic-1002 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-1003 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-1004 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1005 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1006 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1007 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-1008 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1009 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1010 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-1011 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-1012 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1013 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1014 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1015 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-1016 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1017 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1018 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-1019 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-1020 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1021 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1022 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1023 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-1024 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1025 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1026 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-1027 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-1028 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1029 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1030 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1031 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-1032 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1033 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1034 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-1035 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-1036 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1037 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1038 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1039 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-1040 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1041 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1042 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-1043 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-1044 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1045 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1046 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1047 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-1048 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1049 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1050 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 Ic-1051 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 Ic-1052 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1053 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1054 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 Ic-1055 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 Ic-1056 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1057 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 Ic-1058 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Compound 
                 n 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ic-c1 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c2 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c3 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c4 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c5 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c6 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c7 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c8 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c9 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c10 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c11 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c12 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c13 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c14 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c15 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c16 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c17 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c18 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c19 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c20 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c21 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c22 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c23 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c24 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c25 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c26 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c27 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c28 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c29 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c30 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c31 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ic-c32 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ic-c33 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ic-c34 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ic-c35 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ic-c36 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ic-c37 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ic-c38 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ic-c39 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ic-c40 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ic-c41 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ic-c42 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ic-c43 
                 1 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c44 
                 2 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c45 
                 3 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c46 
                 4 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c47 
                 5 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c48 
                 6 
                 —(CH 2 ) n —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c49 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c50 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c51 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c52 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c53 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c54 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c55 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c56 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c57 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c58 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c59 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c60 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c61 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c62 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c63 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c64 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c65 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c66 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c67 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c68 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c69 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c70 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c71 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c72 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c73 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c74 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c75 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c76 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c77 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c78 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c79 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c80 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c81 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c82 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c83 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c84 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c85 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c86 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c87 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c88 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c89 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c90 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c91 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c92 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c93 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c94 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c95 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c96 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Compound 
                 m 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ic-c146 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c147 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c148 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c149 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c150 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c151 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c152 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c153 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c154 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c155 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c156 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c157 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c158 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c159 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c160 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c161 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c162 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c163 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c164 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c165 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c166 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c167 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c168 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c169 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c170 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c171 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ic-c172 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ic-c173 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ic-c174 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ic-c175 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 Ic-c176 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ic-c178 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ic-c179 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ic-c180 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ic-c181 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —F)— 
               
               
                 Ic-c182 
                 2 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c183 
                 3 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c184 
                 4 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c185 
                 5 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c186 
                 6 
                 —O—(CH 2 ) m —N(CH 3 ) 2   
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c187 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c188 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c189 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c190 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c191 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c192 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c193 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c194 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c195 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c196 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c197 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c198 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c199 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c200 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c201 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c202 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c203 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c204 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c205 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c206 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c207 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c208 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c209 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c210 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c211 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c212 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c213 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c214 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c215 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c216 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c217 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c218 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c219 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c220 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c221 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c222 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c223 
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c224 
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c225 
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c226 
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Compound 
                 —R 1   
                 X 
               
               
                   
               
               
                 Ic-c267 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c268 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c269 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c270 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c271 
                 —CH 2 —N(CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c275 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c276 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c277 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c278 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c279 
                 —CH 2 —N(CH 2 —CH 2 —CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c283 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —CH(OH)— 
               
               
                 Ic-c284 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c285 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c286 
                 —CH 2 —N(CH 2 —CH 2 OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c291 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c292 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c293 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c294 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c295 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c296 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c297 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c298 
                 —CH 2 —N(CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ic-c299 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c300 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c301 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c302 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c303 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c304 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c305 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c306 
                 —CH 2 —N(CH 2 —CH 2 —CH 2 —N(CH 3 ) 2 ) 2   
                 N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c307 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c308 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c309 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c310 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c311 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c312 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c313 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c314 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c315 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c316 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c317 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c318 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c319 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c320 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c321 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c322 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c323 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c324 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c325 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c326 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c327 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c328 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c329 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c330 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c331 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c332 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c333 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c334 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c335 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c336 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c337 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c338 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c339 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c340 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c341 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c342 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c343 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c344 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c345 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c346 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c347 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c348 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c349 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c350 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c351 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c352 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c353 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c354 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c355 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c356 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c357 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c358 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c359 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c360 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c361 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c362 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c363 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c364 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c365 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c366 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c367 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c368 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c369 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c370 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c371 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c372 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c373 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c374 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c375 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c376 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c377 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c378 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c379 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c380 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c381 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c382 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c383 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c384 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c385 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c386 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c387 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c388 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c389 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c390 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c391 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c392 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c393 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c394 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c395 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c396 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c397 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c398 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c399 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c400 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c401 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c402 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c403 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c404 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c405 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c406 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c407 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c408 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c409 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c410 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c411 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c412 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c413 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c414 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c415 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c416 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c417 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c418 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c419 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c420 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c421 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c422 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c423 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c424 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c425 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c426 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c427 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c428 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c429 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c430 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c431 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c432 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c433 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c434 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c435 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c436 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c437 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c438 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c439 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c440 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c441 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c442 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c443 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c444 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c445 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c446 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c447 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c448 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c449 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c450 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c451 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c452 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c453 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c454 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c455 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c456 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c457 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c458 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c459 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c460 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c461 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c462 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c463 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c464 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c465 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c466 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c467 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c468 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c469 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c470 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c471 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c472 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c473 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c474 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c475 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c476 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c477 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c478 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c479 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c480 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c481 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c482 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c483 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c484 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c485 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c486 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c487 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c488 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c489 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c490 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c491 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —CH(OH)— 
               
               
                 Ic-c492 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c493 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c494 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c495 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c496 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c497 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c498 
                 —CH 2 —CH 2 —CH 2 —OP(O)(OH) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ic-c499 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —CH(OH)— 
               
               
                 Ic-c500 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c501 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c502 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c503 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c504 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c505 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c506 
                 —CH 2 —CH 2 —CH 2 —OS(O) 2 OH 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c507 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c508 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c509 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c510 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c511 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c512 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c513 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c514 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c515 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c516 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c517 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c518 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c519 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c520 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c521 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c522 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c523 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c524 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c525 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c526 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c527 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c528 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c529 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c530 
                 —(CH 2 ) 10 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ic-c531 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c532 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c533 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c534 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c535 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c536 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c537 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c538 
                 —CH 2 —N(CH 2 —CH 2 —O—CH 3 ) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c539 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c540 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c541 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c542 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c543 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c544 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c545 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c546 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c547 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c548 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c549 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c550 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c551 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c552 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c553 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c554 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c555 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c556 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c557 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c558 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c559 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c560 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c561 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c562 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c563 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c564 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c565 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c566 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c567 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c568 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c569 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c570 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c571 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c572 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c573 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c574 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c575 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c576 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c577 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c578 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c579 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c580 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c581 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c582 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c583 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c584 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c585 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c586 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c587 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c588 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c589 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c590 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c591 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c592 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c593 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c594 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c595 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c596 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c597 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c598 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c599 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c600 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c601 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c602 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c603 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c604 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c605 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c606 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c607 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c608 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c609 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c610 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c611 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —CH(OH)— 
               
               
                 Ic-c612 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c613 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c614 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c615 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c616 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c617 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c618 
                 —CH 2 —NH—CH 2 —CH 2 —CH 2 —N(CH 3 ) 2   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c619 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c620 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c621 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c622 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c623 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c624 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c625 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c626 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c627 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c628 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c629 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c630 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c631 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c632 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c633 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c634 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c635 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c636 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c637 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c638 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c639 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c640 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c641 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c642 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c643 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c644 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c645 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c646 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c647 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c648 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c649 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c650 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c651 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c652 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c653 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c654 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c655 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c656 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c657 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c658 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c659 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c660 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c661 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c662 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c663 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c664 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c665 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c666 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c667 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c668 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c669 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c670 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c671 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c672 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c673 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c674 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c675 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c676 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c677 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c678 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c679 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c680 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c681 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c682 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c683 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c684 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c685 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c686 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c687 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c688 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c689 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c690 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c691 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c692 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c693 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c694 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c695 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c696 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c697 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c698 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c699 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c700 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c701 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c702 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c703 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c704 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c705 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c706 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c707 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c708 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c709 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c710 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c711 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c712 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c713 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c714 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c715 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c716 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c717 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c718 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c719 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c720 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c721 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c722 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c723 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c724 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c725 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c726 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c727 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c728 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c729 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c730 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c731 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c732 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c733 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c734 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c735 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c736 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c737 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c738 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c739 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c740 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c741 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c742 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c743 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c744 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c745 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c746 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c747 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c748 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c749 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c750 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c751 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c752 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c753 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c754 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c755 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c756 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c757 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c758 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c759 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c760 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c761 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c762 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c763 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c764 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c765 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c766 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c767 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c768 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c769 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c770 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c771 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c772 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c773 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c774 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c775 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c776 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c777 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c778 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c779 
                 —CH 2 —NH—CH 3   
                 —CH(OH)— 
               
               
                 Ic-c780 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c781 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c782 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c783 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c784 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c785 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c786 
                 —CH 2 —NH—CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ic-c787 
                 —CH 2 —NH—CH 2 —CH 3   
                 —CH(OH)— 
               
               
                 Ic-c788 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c789 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c790 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c791 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c792 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c793 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c794 
                 —CH 2 —NH—CH 2 —CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ic-c795 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —CH(OH)— 
               
               
                 Ic-c796 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c797 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c798 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c799 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c800 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c801 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c802 
                 —CH 2 —NH—CH 2 —CH 2 —CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c803 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c804 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c805 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c806 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c807 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c808 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c809 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c810 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c811 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c812 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c813 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c814 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c815 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c816 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c817 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c818 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c819 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c820 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c821 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c822 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c823 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c824 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c825 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c826 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c827 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c828 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c829 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c830 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c831 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c832 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c833 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c834 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c835 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c836 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c837 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c838 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c839 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c840 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c841 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c842 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c843 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c844 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c845 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c846 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c847 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c848 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c849 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c850 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c851 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c852 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c853 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c854 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c855 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c856 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c857 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c858 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c859 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c860 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c861 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c862 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c863 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c864 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c865 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c866 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c867 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c868 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c869 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c870 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c871 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c872 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c873 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c874 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c875 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c876 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c877 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c878 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c879 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c880 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c881 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c882 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c883 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c884 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c885 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c886 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c887 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c888 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c889 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c890 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c891 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c892 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c893 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c894 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c895 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c896 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c897 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c898 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c899 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c900 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c901 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c902 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c903 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c904 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c905 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c906 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c907 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c908 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c909 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c910 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c911 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c912 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c913 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c914 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c915 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c916 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c917 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c918 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c919 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c920 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c921 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c922 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c923 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c924 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c925 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c926 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c927 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c928 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c929 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c930 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c931 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c932 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c933 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c934 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c935 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c936 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c937 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c938 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c939 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c940 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c941 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c942 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c943 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c944 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c945 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c946 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c947 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c948 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c949 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c950 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c951 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c952 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c953 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c954 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c955 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c956 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c957 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c958 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c959 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c960 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c961 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c962 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c963 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —CH(OH)— 
               
               
                 Ic-c964 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c965 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c966 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c967 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c968 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c969 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c970 
                 —CH 2 —N(CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ic-c971 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —CH(OH)— 
               
               
                 Ic-c972 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c973 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c974 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c975 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c976 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c977 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c978 
                 —CH 2 —N(CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ic-c979 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —CH(OH)— 
               
               
                 Ic-c980 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c981 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c982 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c983 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c984 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c985 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c986 
                 —CH 2 —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ) 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ic-c987 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —CH(OH)— 
               
               
                 Ic-c988 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c989 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c990 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c991 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c992 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c993 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c994 
                 —CH 2 —NH—CH 2 CH 2 CH 2 CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                 Ic-c995 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —CH(OH)— 
               
               
                 Ic-c996 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 Ic-c997 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 Ic-c998 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 Ic-c999 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c1000 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 Ic-c1001 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                 Ic-c1002 
                 —CH 2 —NH—CH 2 CH 2 —O—CH 3   
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c1003 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c1004 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c1005 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c1006 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c1007 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1008 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1009 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1010 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c1011 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c1012 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c1013 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c1014 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c1015 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1016 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1017 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1018 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c1019 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c1020 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c1021 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c1022 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c1023 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1024 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1025 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1026 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c1027 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c1028 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c1029 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c1030 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c1031 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1032 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1033 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1034 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c1035 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c1036 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c1037 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c1038 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c1039 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1040 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1041 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1042 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c1043 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c1044 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c1045 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c1046 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c1047 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1048 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1049 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1050 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
               
                 Ic-c1051 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 Ic-c1052 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
               
               
                 Ic-c1053 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
               
               
                 Ic-c1054 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
               
               
                 Ic-c1055 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1056 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1057 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—CH 2 —CF 3 )— 
               
               
                   
               
               
                 Ic-c1058 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(O)N(H)—(CH 2 ) 3 —OH)— 
               
               
                   
               
            
           
         
       
     
     and pharmaceutically acceptable salts thereof. 
     5.5 The Indenoisoquinolinone Analogs of Formula (IIa) 
     The present invention provides Indenoisoquinolinone Analogs according to Formula (IIa), below: 
                         
and pharmaceutically acceptable salts thereof,
 
wherein:
 
     X and R 1  are as defined above for the compounds of Formula (Ia). 
     In one embodiment, X is —CH 2 —. In another embodiment, X is —O—. In another embodiment, X is —C(O)—. In another embodiment, X is —NH—. In another embodiment, X is —N(C 1 -C 4  alkyl)-. In another embodiment, X is —S—. In another embodiment, X is —CH(OH)—. 
     In one embodiment, n is 1. In another embodiment, n is 2. 
     In one embodiment, X is —CH 2 — and n is 1. 
     In one embodiment, X is —CH 2 — and n is 2. 
     In one embodiment, X is —CH(OH)— and n is 1. 
     In one embodiment, X is —CH(OH)— and n is 2. 
     In one embodiment, R 2  is —C 1 -C 6  alkyl and R 3  is —C(O)—(C 1 -C 6  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, R 2  is —H and R 3  is —C(O)—(C 1 -C 6  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, n is 1 and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In another embodiment, n is 1 and R 3  is C 3 -C 8  monocyclic cycloalkyl substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In one embodiment, n is 2 and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In another embodiment, n is 2 and R 3  is C 3 -C 8  monocyclic cycloalkyl substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In one embodiment, N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which substituted with one of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)-(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, n is 1 and N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which substituted with one of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)-(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, X is —CH 2 —, n is 1 and N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which substituted with one of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)-(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, X is —CH 2 —, n is 1, and R 2  is C 3 -C 8  monocyclic cycloalkyl. 
     In one embodiment, X is —CH 2 —, n is 1, and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In one embodiment, X is —CH 2 —, n is 1, and R 3  is C 3 -C 8  monocyclic cycloalkyl which is substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In one embodiment, X is —CH 2 —, n is 1, R 2  is —H, and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In one embodiment, X is —CH 2 —, n is 1, R 2  is —H, and R 3  is C 3 -C 8  monocyclic cycloalkyl which is substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In another embodiment, X is —CH 2 —, n is 1 and R 3  is —C(O)—C 1 -C 6  alkylene-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, X is —CH(OH)—, n is 1 and N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which substituted with one of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)-(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, X is —CH(OH)—, n is 1, and R 2  is C 3 -C 8  monocyclic cycloalkyl. 
     In one embodiment, X is —CH(OH)—, n is 1, and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In one embodiment, X is —CH(OH)—, n is 1, and R 3  is C 3 -C 8  monocyclic cycloalkyl which is substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In one embodiment, X is —CH(OH)—, n is 1, R 2  is —H, and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In one embodiment, X is —CH(OH)—, n is 1, R 2  is —H, and R 3  is C 3 -C 8  monocyclic cycloalkyl which is substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In another embodiment, X is —CH(OH)—, n is 1 and R 3  is —C(O)—C 1 -C 6  alkylene-(3- to 7-membered monocyclic heterocycle). 
     In various embodiments, —R 1  is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Illustrative examples of the Indenoisoquinolinone Analogs include the compounds of Formula (IIa) in which n is 1 as set forth below: 
     
       
         
           
               
               
            
               
                   
               
               
                   
                 (IIa) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
            
           
           
               
               
               
            
               
                 Compound 
                 —R 1   
                 X 
               
               
                   
               
               
                 IIa-1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-8 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-25 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-28 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-29 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-30 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-31 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-32 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-33 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-34 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-35 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-36 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-37 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-38 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-39 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-41 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-42 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-43 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-44 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-45 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-46 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-47 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-48 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-49 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-50 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-51 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-52 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-53 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a53 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-54 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-55 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-56 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-57 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-58 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-59 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-60 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-61 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-62 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-63 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-64 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-65 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-66 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a66 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-67 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-68 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-69 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-70 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-71 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-72 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-73 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-74 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-75 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-76 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-77 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-78 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-79 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a79 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-80 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-81 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-82 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-83 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-84 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-85 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-86 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-87 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-88 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-89 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-90 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-91 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-92 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a92 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-93 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-94 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-95 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-96 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-97 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-98 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-99 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-100 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-101 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-102 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-103 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-104 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-105 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a105 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-106 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-107 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-108 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-109 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-110 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-111 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-112 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-113 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-114 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-115 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-116 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-117 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-118 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a118 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-119 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-120 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-121 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-122 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-123 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-124 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-125 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-126 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-127 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-128 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-129 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-130 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-131 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a131 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-132 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-133 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-134 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-135 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-136 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-137 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-138 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-139 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-140 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-141 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-142 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-143 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-144 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a144 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-145 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-146 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-147 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-148 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-149 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-150 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-151 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-152 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-153 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-154 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-155 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-156 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-157 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a157 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-158 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-159 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-160 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-161 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-162 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-163 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-164 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-165 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-166 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-167 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-168 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-169 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-170 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a170 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-171 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-172 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-173 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-174 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-175 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-176 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-177 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-178 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-179 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-180 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-181 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-182 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-183 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-a183 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-184 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-185 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-186 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-187 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-188 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-189 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-190 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-191 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-192 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-193 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-194 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-195 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIa-196 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIa-197 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIa-198 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIa-199 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIa-200 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIa-201 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIa-202 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIa-203 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-204 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-205 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIa-206 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIa-207 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-208 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIa-209 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
            
           
         
       
     
     and pharmaceutically acceptable salts thereof. 
     5.6 The Indenoisoquinolinone Analogs of Formula (IIb) 
     The present invention provides Indenoisoquinolinone Analogs according to Formula (IIb) below: 
     
       
         
         
             
             
         
       
     
     and pharmaceutically acceptable salts thereof, 
     wherein: 
     X and R 1  are as defined above for the compounds of Formula (IIb). 
     In one embodiment, X is —CH 2 —. In another embodiment, X is —O—. In another embodiment, X is —C(O)—. In another embodiment, X is —NH—. In another embodiment, X is —N(C 1 -C 4  alkyl)-. In another embodiment, X is —S—. In another embodiment, X is —CH(OH)—. 
     In one embodiment, n is 1. In another embodiment, n is 2. 
     In one embodiment, X is —CH 2 — and n is 1. 
     In one embodiment, X is —CH 2 — and n is 2. 
     In one embodiment, X is —CH(OH)— and n is 1. 
     In one embodiment, X is —CH(OH)— and n is 2. 
     In one embodiment, R 2  is —C 1 -C 6  alkyl and R 3  is —C(O)—(C 1 -C 6  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, R 2  is —H and R 3  is —C(O)—(C 1 -C 6  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, n is 1 and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In another embodiment, n is 1 and R 3  is C 3 -C 8  monocyclic cycloalkyl substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In one embodiment, n is 2 and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In another embodiment, n is 2 and R 3  is C 3 -C 8  monocyclic cycloalkyl substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In one embodiment, N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which substituted with one of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)-(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, n is 1 and N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which substituted with one of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)-(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, X is —CH 2 —, n is 1 and N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which substituted with one of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)-(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, X is —CH 2 —, n is 1, and R 2  is C 3 -C 8  monocyclic cycloalkyl. 
     In one embodiment, X is —CH 2 —, n is 1, and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In one embodiment, X is —CH 2 —, n is 1, and R 3  is C 3 -C 8  monocyclic cycloalkyl which is substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In one embodiment, X is —CH 2 —, n is 1, R 2  is —H, and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In one embodiment, X is —CH 2 —, n is 1, R 2  is —H, and R 3  is C 3 -C 8  monocyclic cycloalkyl which is substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In another embodiment, X is —CH 2 —, n is 1 and R 3  is —C(O)—C 1 -C 6  alkylene-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, X is —CH(OH)—, n is 1 and N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which substituted with one of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)-(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, X is —CH(OH)—, n is 1, and R 2  is C 3 -C 8  monocyclic cycloalkyl. 
     In one embodiment, X is —CH(OH)—, n is 1, and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In one embodiment, X is —CH(OH)—, n is 1, and R 3  is C 3 -C 8  monocyclic cycloalkyl which is substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In one embodiment, X is —CH(OH)—, n is 1, R 2  is —H, and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In one embodiment, X is —CH(OH)—, n is 1, R 2  is —H, and R 3  is C 3 -C 8  monocyclic cycloalkyl which is substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In another embodiment, X is —CH(OH)—, n is 1 and R 3  is —C(O)—C 1 -C 6  alkylene-(3- to 7-membered monocyclic heterocycle). 
     In various embodiments, —R 1  is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Illustrative examples of the Indenoisoquinolinone Analogs include the compounds of Formula (IIb) in which n is 1 as set forth below: 
     
       
         
           
               
               
               
             
               
                   
               
               
                 Compound 
                 —R 1   
                 X 
               
               
                   
               
             
            
               
                 IIb-1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-8 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-25 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-28 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-29 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-30 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-31 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-32 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-33 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-34 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-35 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-36 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-37 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-38 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-39 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-41 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-42 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-43 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-44 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-45 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-46 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-47 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-48 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-49 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-50 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-51 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-52 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-53 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b53 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-54 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-55 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-56 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-57 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-58 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-59 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-60 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-61 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-62 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-63 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-64 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-65 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-66 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b66 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-67 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-68 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-69 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-70 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-71 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-72 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-73 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-74 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-75 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-76 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-77 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-78 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-79 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b79 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-80 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-81 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-82 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-83 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-84 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-85 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-86 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-87 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-88 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-89 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-90 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-91 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-92 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b92 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-93 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-94 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-95 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-96 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-97 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-98 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-99 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-100 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-101 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-102 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-103 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-104 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-105 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b105 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-106 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-107 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-108 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-109 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-110 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-111 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-112 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-113 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-114 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-115 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-116 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-117 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-118 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b118 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-119 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-120 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-121 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-122 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-123 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-124 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-125 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-126 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-127 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-128 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-129 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-130 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-131 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b131 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-132 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-133 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-134 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-135 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-136 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-137 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-138 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-139 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-140 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-141 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-142 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-143 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-144 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b144 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-145 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-146 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-147 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-148 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-149 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-150 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-151 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-152 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-153 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-154 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-155 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-156 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-157 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b157 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-158 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-159 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-160 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-161 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-162 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-163 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-164 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-165 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-166 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-167 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-168 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-169 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-170 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b170 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-171 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-172 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-173 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-174 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-175 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-176 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-177 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-178 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-179 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-180 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-181 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-182 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-183 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-b183 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-184 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-185 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-186 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-187 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-188 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-189 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-190 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-191 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-192 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-193 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-194 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-195 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-196 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-197 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-198 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-199 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-200 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-201 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-202 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-203 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-204 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-205 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-206 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-207 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-208 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-209 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIb-210 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIb-211 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIb-212 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIb-213 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIb-214 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIb-215 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIb-216 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIb-217 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-218 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-219 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIb-220 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIb-221 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-222 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIb-223 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
            
           
         
       
     
     and pharmaceutically acceptable salts thereof. 
     5.7 The Indenoisoquinolinone Analogs of Formula (IIc) 
     The present invention provides Indenoisoquinolinone Analogs according to Formula (IIc) below: 
                         
and pharmaceutically acceptable salts thereof,
 
wherein:
 
     X and R 1  are as defined above for the compounds of Formula (IIc). 
     In one embodiment, X is —CH 2 —. In another embodiment, X is —O—. In another embodiment, X is —C(O)—. In another embodiment, X is —NH—. In another embodiment, X is —N(C 1 -C 4  alkyl)-. In another embodiment, X is —S—. In another embodiment, X is —CH(OH)—. 
     In one embodiment, n is 1. In another embodiment, n is 2. 
     In one embodiment, X is —CH 2 — and n is 1. 
     In one embodiment, X is —CH 2 — and n is 2. 
     In one embodiment, X is —CH(OH)— and n is 1. 
     In one embodiment, X is —CH(OH)— and n is 2. 
     In one embodiment, R 2  is —C 1 -C 6  alkyl and R 3  is —C(O)—(C 1 -C 6  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, R 2  is —H and R 3  is —C(O)—(C 1 -C 6  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, n is 1 and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In another embodiment, n is 1 and R 3  is C 3 -C 8  monocyclic cycloalkyl substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In one embodiment, n is 2 and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In another embodiment, n is 2 and R 3  is C 3 -C 8  monocyclic cycloalkyl substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In one embodiment, N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which substituted with one of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)-(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, n is 1 and N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which substituted with one of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)-(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, X is —CH 2 —, n is 1 and N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which substituted with one of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)-(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, X is —CH 2 —, n is 1, and R 2  is C 3 -C 8  monocyclic cycloalkyl. 
     In one embodiment, X is —CH 2 —, n is 1, and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In one embodiment, X is —CH 2 —, n is 21, and R 3  is C 3 -C 8  monocyclic cycloalkyl which is substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In one embodiment, X is —CH 2 —, n is 1, R 2  is —H, and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In one embodiment, X is —CH 2 —, n is 1, R 2  is —H, and R 3  is C 3 -C 8  monocyclic cycloalkyl which is substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In another embodiment, X is —CH 2 —, n is 1 and R 3  is —C(O)—C 1 -C 6  alkylene-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, X is —CH(OH)—, n is 1 and N, R 2  and R 3  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which substituted with one of —C 2 -C 6  alkenyl, —C(O)—C 1 -C 6  alkyl, —(C 1 -C 4  alkylene)-C(O)—(C 3 -C 8  monocyclic cycloalkyl), —C 7 -C 10  alkyl, —(C 1 -C 5  alkylene)-C(H)(—O—C 1 -C 4  alkyl) 2 , -(cyano-substituted) C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)-(nitrogen-containing 3- to 7-membered monocyclic heterocycle), or —(C 1 -C 5  alkylene)-(3- to 7-membered monocyclic heterocycle). 
     In one embodiment, X is —CH(OH)—, n is 1, and R 2  is C 3 -C 8  monocyclic cycloalkyl. 
     In one embodiment, X is —CH(OH)—, n is 1, and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In one embodiment, X is —CH(OH)—, n is 1, and R 3  is C 3 -C 8  monocyclic cycloalkyl which is substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In one embodiment, X is —CH(OH)—, n is 1, R 2  is —H, and R 3  is a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is substituted with one —C(O)O—C 1 -C 6  alkyl. 
     In one embodiment, X is —CH(OH)—, n is 1, R 2  is —H, and R 3  is C 3 -C 8  monocyclic cycloalkyl which is substituted with one hydroxy-substituted C 1 -C 5  alkyl. 
     In another embodiment, X is —CH(OH)—, n is 1 and R 3  is —C(O)—C 1 -C 6  alkylene-(3- to 7-membered monocyclic heterocycle). 
     In various embodiments, —R 1  is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Illustrative examples of the Indenoisoquinolinone Analogs include the compounds of Formula (IIc) in which n is 1 as set forth below: 
     
       
         
           
               
               
               
             
               
                   
               
               
                 Compound 
                 —R 1   
                 X 
               
               
                   
               
             
            
               
                 IIc-1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-8 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-25 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-28 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-29 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-30 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-31 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-32 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-33 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-34 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-35 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-36 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-37 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-38 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-39 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-41 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-42 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-43 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-44 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-45 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-46 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-47 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-48 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-49 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-50 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-51 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-52 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-53 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c53 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-54 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-55 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-56 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-57 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-58 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-59 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-60 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-61 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-62 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-63 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-64 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-65 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-66 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c66 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-67 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-68 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-69 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-70 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-71 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-72 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-73 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-74 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-75 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-76 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-77 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-78 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-79 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c79 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-80 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-81 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-82 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-83 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-84 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-85 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-86 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-87 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-88 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-89 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-90 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-91 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-92 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c92 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-93 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-94 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-95 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-96 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-97 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-98 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-99 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-100 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-101 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-102 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-103 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-104 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-105 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c105 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-106 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-107 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-108 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-109 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-110 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-111 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-112 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-113 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-114 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-115 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-116 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-117 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-118 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c118 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-119 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-120 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-121 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-122 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-123 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-124 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-125 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-126 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-127 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-128 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-129 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-130 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-131 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c131 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-132 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-133 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-134 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-135 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-136 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-137 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-138 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-139 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-140 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-141 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-142 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-143 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-144 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c144 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-145 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-146 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-147 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-148 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-149 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-150 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-151 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-152 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-153 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-154 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-155 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-156 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-157 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c157 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-158 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-159 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-160 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-161 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-162 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-163 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-164 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-165 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-166 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-167 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-168 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-169 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-170 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c170 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-171 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-172 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-173 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-174 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-175 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-176 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-177 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-178 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-179 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-180 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-181 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-182 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-183 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-c183 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-184 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-185 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-186 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-187 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-188 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-189 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-190 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-191 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-192 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-193 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-194 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-195 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
               
                 IIc-196 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH 2 — 
               
               
                   
               
               
                 IIc-197 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —CH(OH)— 
               
               
                   
               
               
                 IIc-198 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —O— 
               
               
                   
               
               
                 IIc-199 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —C(O)— 
               
               
                   
               
               
                 IIc-200 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —NH— 
               
               
                   
               
               
                 IIc-201 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —S— 
               
               
                   
               
               
                 IIc-202 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 3 )— 
               
               
                   
               
               
                 IIc-203 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-204 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-205 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
               
               
                 IIc-206 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
               
               
                 IIc-207 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-208 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
               
               
                 IIc-209 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
               
            
           
         
       
     
     and pharmaceutically acceptable salts thereof. 
     5.8 The Indenoisoquinolinone Analogs of Formula (IIIa) 
     The present invention provides the following Indenoisoquinolinone Analogs according to Formula (IIIa) as set forth below: 
     
       
         
           
               
               
            
               
                   
               
               
                   
                 (IIIa) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Compound 
                 —R 1   
               
               
                   
                   
               
               
                   
                 IIIa-1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-8 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIa-24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
            
           
         
       
     
     and pharmaceutically acceptable salts thereof. 
     5.9 The Indenoisoquinolinone Analogs of Formula (IIIb) 
     The present invention provides the following Indenoisoquinolinone Analogs according to Formula (IIIb) as set forth below: 
     
       
         
           
               
               
            
               
                   
               
               
                   
                 (IIIb) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Compound 
                 —R 1   
               
               
                   
                   
               
               
                   
                 IIIb-1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-8 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 IIIb-24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
            
           
         
       
     
     and pharmaceutically acceptable salts thereof. 
     5.10 The Indenoisoquinolinone Analogs of Formula (IVa) 
     The present invention provides Indenoisoquinolinone Analogs according to Formula (IVa), below: 
                         
and pharmaceutically acceptable salts thereof,
 
wherein X and R 1  are as defined above for the Indenoisoquinolinone Analogs of Formula (IVa).
 
     In one embodiment, X is —N(CH 3 )—. In another embodiment, X is —N(CH 2 CH 3 )—. In another embodiment, X is —N(CH 2 CH 2 CH 3 )—. In another embodiment, X is —N(CH 2 CH 2 CH 2 CH 3 )—. In another embodiment, X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. In another embodiment, X is —N(C(H)(CH 3 ) 2 )—. In another embodiment, X is —N(CH 2 C(H)(CH 3 ) 2 )—. In another embodiment, X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, X is —O—. In one embodiment, X is —CH 2 —. In one embodiment, X is —C(O)—. In one embodiment, X is —NH—. In one embodiment, X is —S—. In one embodiment, X is —CH(OH)—. 
     In one embodiment, each C 1 -C 3  alkyl is independent of the other C 1 -C 3  alkyl. 
     In one embodiment, each C 1 -C 3  alkyl is methyl. 
     In one embodiment, each C 1 -C 3  alkyl is methyl and X is —CH 2 —. 
     In one embodiment, each C 1 -C 3  alkyl is methyl and X is —CH(OH)—. 
     In one embodiment, each C 1 -C 3  alkyl is methyl, X is —CH 2 — and n is 1. 
     In one embodiment, each C 1 -C 3  alkyl is methyl, X is —CH(OH)— and n is 1. 
     In another embodiment, X is —CH(OH)— and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —Z)— and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—Z)— and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —Z)—. 
     In another embodiment, X is —N((CH 2 )—Z)—. 
     In another embodiment, X is —N((CH 2 ) 2 —Z)—. 
     In another embodiment, X is —N((CH 2 ) q —Z)— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —Z)— and n is 2. 
     In still another embodiment, X is —N((CH 2 )—Z)— and n is 1. 
     In still another embodiment, X is —N((CH 2 )—Z)— and n is 2. 
     In one embodiment, Z is —CF 3 . 
     In another embodiment, Z is —F. 
     In yet another embodiment, Z is —OH. 
     In still another embodiment, Z is —O—CH 3 . 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)— and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)— and n is 1. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)— and n is 2. 
     In one embodiment, X is —N((CH 2 ) q —OH)—. 
     In another embodiment, X is —N((CH 2 ) 2 —OH)—. 
     In another embodiment, X is —N((CH 2 ) q —OH)— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —OH)— and n is 2. 
     In still another embodiment, X is —N((CH 2 ) 2 —OH)— and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—F)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)— n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—F)— and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —F)—. 
     In another embodiment, X is —N((CH 2 )—F)—. 
     In another embodiment, X is —N((CH 2 ) q —F)— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —F)— and n is 2. 
     In still another embodiment, X is —N((CH 2 )—F)— and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)-. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OMe)-. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)- and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)- and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OMe)- and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —OMe)-. 
     In another embodiment, X is —N((CH 2 ) 2 —OMe)-. 
     In another embodiment, X is —N((CH 2 ) q —OMe)- and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —OMe)- and n is 2. 
     In still another embodiment, X is —N((CH 2 ) 2 —OMe)- and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )— and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —CF 3 )—. 
     In another embodiment, X is —N((CH 2 )—CF 3 )—. 
     In another embodiment, X is —N((CH 2 ) q —CF 3 )— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —CF 3 )— and n is 2. 
     In still another embodiment, X is —N((CH 2 )—CF 3 )— and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )— and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —CF 3 )—. 
     In another embodiment, X is —N((CH 2 )—CF 3 )—. 
     In another embodiment, X is —N((CH 2 ) q —CF 3 )— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —CF 3 )— and n is 2. 
     In still another embodiment, X is —N((CH 2 )—CF 3 )— and n is 1. 
     In one embodiment, n is 1. 
     In another embodiment, n is 2. 
     In yet another embodiment, n is 3. 
     In a further embodiment, n is 4, 5, or 6. 
     In yet a further embodiment, n is 7, 8, or 9. 
     In still a further embodiment, n is 10. 
     In one embodiment, p is 1. 
     In another embodiment, p is 2. 
     In yet another embodiment, p is an integer ranging from 2 to 5. 
     In one embodiment, q is 1. 
     In another embodiment, q is 2. 
     In yet another embodiment, q is an integer ranging from 2 to 5. 
     In one embodiment, n is 1 and X is —N(CH 3 )—. 
     In another embodiment, n is 1 and X is —N(CH 2 CH 3 ). 
     In another embodiment, n is 1 and X is —N(CH 2 CH 2 CH 3 )—. 
     In another embodiment, n is 1 and X is —N(CH 2 CH 2 CH 2 CH 3 )—. 
     In another embodiment, n is 1 and X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. 
     In another embodiment, n is 1 and X is —N(C(H)(CH 3 ) 2 )—. 
     In another embodiment, n is 1 and X is —N(CH 2 C(H)(CH 3 ) 2 )—. 
     In another embodiment, n is 1 and X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, one R 2  is —H, and the other R 2  is —C 1 -C 6  alkyl. 
     In another embodiment, each R 2  is —C 1 -C 6  alkyl. 
     In another embodiment, each R 2  is -methyl. 
     In various embodiments, —N(R 2 )(R 2 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In other embodiments, —N(R 2 )(R 2 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In some embodiments, —N(R 2 )(R 2 ) is 
     
       
         
         
             
             
         
       
     
     In still other embodiments, —N(R 2 )(R 2 ) is
         —N(CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ),   —NH—CH 2 CH 2 CH 2 CH 3 , or   —NH—CH 2 CH 2 —O—CH 3 .       

     In some embodiments, —N(R 2 )(R 2 ) is 
     
       
         
         
             
             
         
       
     
     In various embodiments, —N(Z 3 )(Z 4 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In other embodiments, —N(Z 3 )(Z 4 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In some embodiments, —N(Z 3 )(Z 4 ) is 
     
       
         
         
             
             
         
       
     
     In still other embodiments, —N(Z 3 )(Z 4 ) is
         —N(CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ),   —NH—CH 2 CH 2 CH 2 CH 3 , or   —NH—CH 2 CH 2 —O—CH 3 .       

     In some embodiments, —N(Z 3 )(Z 4 ) is 
     
       
         
         
             
             
         
       
     
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; 
     n is an integer ranging from 1 to 3; 
     each R 2  is independently —H, —C 1 -C 6  alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —(C 1 -C 6  alkylene)-phenyl or -phenyl, each of which other than hydrogen is unsubstituted or substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH or —N(Z 3 )(Z 4 ), where Z 3  and Z 4  are independently —H, —C 1 -C 5  alkyl, or —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, each of which other than hydrogen is unsubstituted or substituted with one or more of -halo, —OH or —NH 2 ; 
     or N, Z 3  and Z 4  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one to three of —C 1 -C 5  alkyl, -phenyl, —(C 1 -C 5  alkylene)-phenyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —C 1 -C 5  alkylene-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, or —C 1 -C 10  alkyl; 
     or N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one to three of —C 1 -C 5  alkyl, -phenyl, —(C 1 -C 5  alkylene)-phenyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —(C 1 -C 5  alkylene)-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, or —C 1 -C 10  alkyl. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; 
     n is an integer ranging from 1 to 3; and 
     at least one C 1 -C 3  alkyl is methyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; at least one C 1 -C 3  alkyl is methyl; and at least one R 2  is ethyl. 
     In yet another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; at least one C 1 -C 3  alkyl is methyl; and at least one R 2  is propyl. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; at least one C 1 -C 3  alkyl is methyl; and at least one R 2  is —C 3 -C 8  monocyclic cycloalkyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; at least one C 1 -C 3  alkyl is methyl; and at least one R 2  is cyclohexyl. 
     In yet another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; and at least one C 1 -C 3  alkyl is methyl, wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; and at least one C 1 -C 3  alkyl is methyl, wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with a hydroxyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 )— or —N(C(CH 3 ) 3 )—; and at least one C 1 -C 3  alkyl is methyl, wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with a nitrogen-containing 3- to 7-membered monocyclic heterocycle. 
     Illustrative examples of the Indenoisoquinolinone Analogs include the compounds of Formula (IVa) as set forth below: 
     
       
         
           
               
               
            
               
                   
               
               
                   
                 (IVa) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Compound 
                 —R 1   
                 X 
               
               
                   
               
               
                 IVa-1 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —O— 
               
               
                 IVa-2 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —CH 2 — 
               
               
                 IVa-3 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —C(O)— 
               
               
                 IVa-4 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —NH— 
               
               
                 IVa-5 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —S— 
               
               
                 IVa-6 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 3 )— 
               
               
                 IVa-7 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 3 )— 
               
               
                 IVa-8 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 IVa-9 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 IVa-10 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 IVa-11 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 IVa-12 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 IVa-13 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 IVa-14 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —CH(OH)— 
               
               
                 IVa-15 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 IVa-16 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 IVa-17 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 IVa-18 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —F)— 
               
               
                 IVa-19 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVa-20 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —CF 3 )— 
               
               
                 IVa-21 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVa-22 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 IVa-23 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —O— 
               
               
                 IVa-24 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —CH 2 — 
               
               
                 IVa-25 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —C(O)— 
               
               
                 IVa-26 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —NH— 
               
               
                 IVa-27 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —S— 
               
               
                 IVa-28 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 3 )— 
               
               
                 IVa-29 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 3 )— 
               
               
                 IVa-30 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 IVa-31 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 IVa-32 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 IVa-33 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 IVa-34 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 IVa-35 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 IVa-36 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —CH(OH)— 
               
               
                 IVa-37 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 IVa-38 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 IVa-39 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 IVa-40 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —F)— 
               
               
                 IVa-41 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVa-42 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —CF 3 )— 
               
               
                 IVa-43 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVa-44 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 IVa-45 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —O— 
               
               
                 IVa-46 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —CH 2 — 
               
               
                 IVa-47 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —C(O)— 
               
               
                 IVa-48 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —NH— 
               
               
                 IVa-49 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —S— 
               
               
                 IVa-50 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 3 )— 
               
               
                 IVa-51 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 3 )— 
               
               
                 IVa-52 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 IVa-53 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 IVa-54 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 IVa-55 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 IVa-56 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 IVa-57 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 IVa-58 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —CH(OH)— 
               
               
                 IVa-59 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 IVa-60 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 IVa-61 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 IVa-62 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —F)— 
               
               
                 IVa-63 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVa-64 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —CF 3 )— 
               
               
                 IVa-65 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVa-66 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 IVa-67 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —O— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-68 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —CH 2 — 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-69 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —C(O)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-70 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —NH— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-71 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —S— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-72 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-73 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 CH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-74 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-75 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-76 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-77 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-78 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-79 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-80 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —CH(OH)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-81 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-82 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-83 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-84 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-85 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-86 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 —CH 2 —CF 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-87 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVa-88 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                   
               
            
           
         
       
     
     and pharmaceutically acceptable salts thereof. 
     5.11 The Indenoisoquinolinone Analogs of Formula (IVb) 
     The present invention provides Indenoisoquinolinone Analogs according to Formula (IVb), below: 
                         
and pharmaceutically acceptable salts thereof,
 
wherein X and R 1  are as defined above for the Indenoisoquinolinone Analogs of Formula (IVb).
 
     In one embodiment, X is —N(CH 3 )—. In another embodiment, X is —N(CH 2 CH 3 )—. In another embodiment, X is —N(CH 2 CH 2 CH 3 )—. In another embodiment, X is —N(CH 2 CH 2 CH 2 CH 3 )—. In another embodiment, X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. In another embodiment, X is —N(C(H)(CH 3 ) 2 )—. In another embodiment, X is —N(CH 2 C(H)(CH 3 ) 2 )—. In another embodiment, X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, X is —O—. In one embodiment, X is —CH 2 —. In one embodiment, X is —C(O)—. In one embodiment, X is —NH—. In one embodiment, X is —S—. In one embodiment, X is —CH(OH)—. 
     In one embodiment, each C 1 -C 3  alkyl is independent of the other C 1 -C 3  alkyl. 
     In one embodiment, each C 1 -C 3  alkyl is methyl. 
     In one embodiment, each C 1 -C 3  alkyl is methyl and X is —CH 2 —. 
     In one embodiment, each C 1 -C 3  alkyl is methyl and X is —CH(OH)—. 
     In one embodiment, each C 1 -C 3  alkyl is methyl, X is —CH 2 — and n is 1. 
     In one embodiment, each C 1 -C 3  alkyl is methyl, X is —CH(OH)— and n is 1. 
     In another embodiment, X is —CH(OH)— and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —Z)— and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—Z)— and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —Z)—. 
     In another embodiment, X is —N((CH 2 )—Z)—. 
     In another embodiment, X is —N((CH 2 ) 2 —Z)—. 
     In another embodiment, X is —N((CH 2 ) q —Z)— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —Z)— and n is 2. 
     In still another embodiment, X is —N((CH 2 )—Z)— and n is 1. 
     In still another embodiment, X is —N((CH 2 )—Z)— and n is 2. 
     In one embodiment, Z is —CF 3 . 
     In another embodiment, Z is —F. 
     In yet another embodiment, Z is —OH. 
     In still another embodiment, Z is —O—CH 3 . 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)— and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)— and n is 1. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)— and n is 2. 
     In one embodiment, X is —N((CH 2 ) q —OH)—. 
     In another embodiment, X is —N((CH 2 ) 2 —OH)—. 
     In another embodiment, X is —N((CH 2 ) q —OH)— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —OH)— and n is 2. 
     In still another embodiment, X is —N((CH 2 ) 2 —OH)— and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—F)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)— n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—F)— and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —F)—. 
     In another embodiment, X is —N((CH 2 )—F)—. 
     In another embodiment, X is —N((CH 2 ) q —F)— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —F)— and n is 2. 
     In still another embodiment, X is —N((CH 2 )—F)— and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)-. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OMe)-. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)- and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)- and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OMe)- and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —OMe)-. 
     In another embodiment, X is —N((CH 2 ) 2 —OMe)-. 
     In another embodiment, X is —N((CH 2 ) q —OMe)- and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —OMe)- and n is 2. 
     In still another embodiment, X is —N((CH 2 ) 2 —OMe)- and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )— and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —CF 3 )—. 
     In another embodiment, X is —N((CH 2 )—CF 3 )—. 
     In another embodiment, X is —N((CH 2 ) q —CF 3 )— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —CF 3 )— and n is 2. 
     In still another embodiment, X is —N((CH 2 )—CF 3 )— and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )— and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —CF 3 )—. 
     In another embodiment, X is —N((CH 2 )—CF 3 )—. 
     In another embodiment, X is —N((CH 2 ) q —CF 3 )— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —CF 3 )— and n is 2. 
     In still another embodiment, X is —N((CH 2 )—CF 3 )— and n is 1. 
     In one embodiment, n is 1. 
     In another embodiment, n is 2. 
     In yet another embodiment, n is 3. 
     In a further embodiment, n is 4, 5, or 6. 
     In yet a further embodiment, n is 7, 8, or 9. 
     In still a further embodiment, n is 10. 
     In one embodiment, p is 1. 
     In another embodiment, p is 2. 
     In yet another embodiment, p is an integer ranging from 2 to 5. 
     In one embodiment, q is 1. 
     In another embodiment, q is 2. 
     In yet another embodiment, q is an integer ranging from 2 to 5. 
     In one embodiment, n is 1 and X is —N(CH 3 )—. 
     In another embodiment, n is 1 and X is —N(CH 2 CH 3 ). 
     In another embodiment, n is 1 and X is —N(CH 2 CH 2 CH 3 )—. 
     In another embodiment, n is 1 and X is —N(CH 2 CH 2 CH 2 CH 3 )—. 
     In another embodiment, n is 1 and X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. 
     In another embodiment, n is 1 and X is —N(C(H)(CH 3 ) 2 )—. 
     In another embodiment, n is 1 and X is —N(CH 2 C(H)(CH 3 ) 2 )—. 
     In another embodiment, n is 1 and X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, one R 2  is —H, and the other R 2  is —C 1 -C 6  alkyl. 
     In another embodiment, each R 2  is —C 1 -C 6  alkyl. 
     In another embodiment, each R 2  is -methyl. 
     In various embodiments, —N(R 2 )(R 2 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In other embodiments, —N(R 2 )(R 2 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In some embodiments, —N(R 2 )(R 2 ) is 
     
       
         
         
             
             
         
       
     
     In still other embodiments, —N(R 2 )(R 2 ) is
         —N(CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ),   —NH—CH 2 CH 2 CH 2 CH 3 , or   —NH—CH 2 CH 2 —O—CH 3 .       

     In some embodiments, —N(R 2 )(R 2 ) is 
     
       
         
         
             
             
         
       
     
     In various embodiments, —N(Z 3 )(Z 4 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In other embodiments, —N(Z 3 )(Z 4 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In some embodiments, —N(Z 3 )(Z 4 ) is 
     
       
         
         
             
             
         
       
     
     In still other embodiments, —N(Z 3 )(Z 4 ) is
         —N(CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ),   —NH—CH 2 CH 2 CH 2 CH 3 , or   —NH—CH 2 CH 2 —O—CH 3 .       

     In some embodiments, —N(Z 3 )(Z 4 ) is 
     
       
         
         
             
             
         
       
     
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; 
     n is an integer ranging from 1 to 3; 
     each R 2  is independently —H, —C 1 -C 6  alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —(C 1 -C 6  alkylene)-phenyl or -phenyl, each of which other than hydrogen is unsubstituted or substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH or —N(Z 3 )(Z 4 ), where Z 3  and Z 4  are independently —H, —C 1 -C 5  alkyl, or —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, each of which other than hydrogen is unsubstituted or substituted with one or more of -halo, —OH or —NH 2 ; 
     or N, Z 3  and Z 4  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one to three of —C 1 -C 5  alkyl, -phenyl, —(C 1 -C 5  alkylene)-phenyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —C 1 -C 5  alkylene-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, or —C 1 -C 10  alkyl; 
     or N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one to three of —C 1 -C 5  alkyl, -phenyl, —(C 1 -C 5  alkylene)-phenyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —(C 1 -C 5  alkylene)-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, or —C 1 -C 10  alkyl. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; 
     n is an integer ranging from 1 to 3; and 
     at least one C 1 -C 3  alkyl is methyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; at least one C 1 -C 3  alkyl is methyl; and at least one R 2  is ethyl. 
     In yet another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; at least one C 1 -C 3  alkyl is methyl; and at least one R 2  is propyl. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; at least one C 1 -C 3  alkyl is methyl; and at least one R 2  is —C 3 -C 8  monocyclic cycloalkyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; at least one C 1 -C 3  alkyl is methyl; and at least one R 2  is cyclohexyl. 
     In yet another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; and at least one C 1 -C 3  alkyl is methyl, wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; and at least one C 1 -C 3  alkyl is methyl, wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with a hydroxyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; and at least one C 1 -C 3  alkyl is methyl, wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with a nitrogen-containing 3- to 7-membered monocyclic heterocycle. 
     Illustrative examples of the Indenoisoquinolinone Analogs include the compounds of Formula (IVb) as set forth below: 
     
       
         
           
               
               
            
               
                   
               
               
                   
                 (IVb) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Compound 
                 —R 1   
                 X 
               
               
                   
               
               
                 IVb-1 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —O— 
               
               
                 IVb-2 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —CH 2 — 
               
               
                 IVb-3 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —C(O)— 
               
               
                 IVb-4 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —NH— 
               
               
                 IVb-5 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —S— 
               
               
                 IVb-6 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 3 )— 
               
               
                 IVb-7 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 3 )— 
               
               
                 IVb-8 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 IVb-9 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 IVb-10 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 IVb-11 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 IVb-12 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 IVb-13 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 IVb-14 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —CH(OH)— 
               
               
                 IVb-15 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 IVb-16 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 IVb-17 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 IVb-18 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —F)— 
               
               
                 IVb-19 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVb-20 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —CF 3 )— 
               
               
                 IVb-21 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVb-22 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 IVb-23 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —O— 
               
               
                 IVb-24 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —CH 2 — 
               
               
                 IVb-25 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —C(O)— 
               
               
                 IVb-26 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —NH— 
               
               
                 IVb-27 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —S— 
               
               
                 IVb-28 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 3 )— 
               
               
                 IVb-29 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 3 )— 
               
               
                 IVb-30 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 IVb-31 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 IVb-32 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 IVb-33 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 IVb-34 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 IVb-35 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 IVb-36 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —CH(OH)— 
               
               
                 IVb-37 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 IVb-38 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 IVb-39 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 IVb-40 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —F)— 
               
               
                 IVb-41 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVb-42 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —CF 3 )— 
               
               
                 IVb-43 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVb-44 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 IVb-45 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —O— 
               
               
                 IVb-46 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —CH 2 — 
               
               
                 IVb-47 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —C(O)— 
               
               
                 IVb-48 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —NH— 
               
               
                 IVb-49 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —S— 
               
               
                 IVb-50 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 3 )— 
               
               
                 IVb-51 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 3 )— 
               
               
                 IVb-52 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 IVb-53 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 IVb-54 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 IVb-55 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 IVb-56 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 IVb-57 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 IVb-58 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —CH(OH)— 
               
               
                 IVb-59 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 IVb-60 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 IVb-61 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 IVb-62 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —F)— 
               
               
                 IVb-63 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVb-64 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —CF 3 )— 
               
               
                 IVb-65 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVb-66 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 IVb-67 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —O— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-68 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —CH 2 — 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-69 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —C(O)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-70 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —NH— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-71 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —S— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-72 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-73 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 CH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-74 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-75 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-76 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-77 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-78 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-79 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-80 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —CH(OH)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-81 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-82 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-83 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-84 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-85 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-86 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 —CH 2 —CF 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-87 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVb-88 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                   
               
            
           
         
       
     
     and pharmaceutically acceptable salts thereof. 
     5.12 The Indenoisoquinolinone Analogs of Formula (IVc) 
     The present invention provides Indenoisoquinolinone Analogs according to Formula (IVc), below: 
                         
and pharmaceutically acceptable salts thereof,
 
wherein X and R 1  are as defined above for the Indenoisoquinolinone Analogs of Formula (IVc).
 
     In one embodiment, X is —N(CH 3 )—. In another embodiment, X is —N(CH 2 CH 3 )—. In another embodiment, X is —N(CH 2 CH 2 CH 3 )—. In another embodiment, X is —N(CH 2 CH 2 CH 2 CH 3 )—. In another embodiment, X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. In another embodiment, X is —N(C(H)(CH 3 ) 2 )—. In another embodiment, X is —N(CH 2 C(H)(CH 3 ) 2 )—. In another embodiment, X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, X is —O—. In one embodiment, X is —CH 2 —. In one embodiment, 
     X is —C(O)—. In one embodiment, X is —NH—. In one embodiment, X is —S—. In one embodiment, X is —CH(OH)—. 
     In one embodiment, each C 1 -C 3  alkyl is independent of the other C 1 -C 3  alkyl. 
     In one embodiment, each C 1 -C 3  alkyl is methyl. 
     In one embodiment, each C 1 -C 3  alkyl is methyl and X is —CH 2 —. 
     In one embodiment, each C 1 -C 3  alkyl is methyl and X is —CH(OH)—. 
     In one embodiment, each C 1 -C 3  alkyl is methyl, X is —CH 2 — and n is 1. 
     In one embodiment, each C 1 -C 3  alkyl is methyl, X is —CH(OH)— and n is 1. 
     In another embodiment, X is —CH(OH)— and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —Z)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —Z)— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —Z)— and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—Z)— and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —Z)—. 
     In another embodiment, X is —N((CH 2 )—Z)—. 
     In another embodiment, X is —N((CH 2 ) 2 —Z)—. 
     In another embodiment, X is —N((CH 2 ) q —Z)— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —Z)— and n is 2. 
     In still another embodiment, X is —N((CH 2 )—Z)— and n is 1. 
     In still another embodiment, X is —N((CH 2 )—Z)— and n is 2. 
     In one embodiment, Z is —CF 3 . 
     In another embodiment, Z is —F. 
     In yet another embodiment, Z is —OH. 
     In still another embodiment, Z is —O—CH 3 . 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OH)— and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)— and n is 1. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OH)— and n is 2. 
     In one embodiment, X is —N((CH 2 ) q —OH)—. 
     In another embodiment, X is —N((CH 2 ) 2 —OH)—. 
     In another embodiment, X is —N((CH 2 ) q —OH)— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —OH)— and n is 2. 
     In still another embodiment, X is —N((CH 2 ) 2 —OH)— and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—F)—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —F)— n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—F)— and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —F)—. 
     In another embodiment, X is —N((CH 2 )—F)—. 
     In another embodiment, X is —N((CH 2 ) q —F)— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —F)— and n is 2. 
     In still another embodiment, X is —N((CH 2 )—F)— and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)-. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OMe)-. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)- and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —OMe)- and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 ) 2 —OMe)- and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —OMe)-. 
     In another embodiment, X is —N((CH 2 ) 2 —OMe)-. 
     In another embodiment, X is —N((CH 2 ) q —OMe)- and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —OMe)- and n is 2. 
     In still another embodiment, X is —N((CH 2 ) 2 —OMe)- and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )— and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —CF 3 )—. 
     In another embodiment, X is —N((CH 2 )—CF 3 )—. 
     In another embodiment, X is —N((CH 2 ) q —CF 3 )— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —CF 3 )— and n is 2. 
     In still another embodiment, X is —N((CH 2 )—CF 3 )— and n is 1. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )—. 
     In another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and n is 1. 
     In yet another embodiment, X is —N(C(O)N(H)—(CH 2 ) p —CF 3 )— and n is 2. 
     In still another embodiment, X is —N(C(O)N(H)—(CH 2 )—CF 3 )— and n is 1. 
     In one embodiment, X is —N((CH 2 ) q —CF 3 )—. 
     In another embodiment, X is —N((CH 2 )—CF 3 )—. 
     In another embodiment, X is —N((CH 2 ) q —CF 3 )— and n is 1. 
     In yet another embodiment, X is —N((CH 2 ) q —CF 3 )— and n is 2. 
     In still another embodiment, X is —N((CH 2 )—CF 3 )— and n is 1. 
     In one embodiment, n is 1. 
     In another embodiment, n is 2. 
     In yet another embodiment, n is 3. 
     In a further embodiment, n is 4, 5, or 6. 
     In yet a further embodiment, n is 7, 8, or 9. 
     In still a further embodiment, n is 10. 
     In one embodiment, p is 1. 
     In another embodiment, p is 2. 
     In yet another embodiment, p is an integer ranging from 2 to 5. 
     In one embodiment, q is 1. 
     In another embodiment, q is 2. 
     In yet another embodiment, q is an integer ranging from 2 to 5. 
     In one embodiment, n is 1 and X is —N(CH 3 )—. 
     In another embodiment, n is 1 and X is —N(CH 2 CH 3 ). 
     In another embodiment, n is 1 and X is —N(CH 2 CH 2 CH 3 )—. 
     In another embodiment, n is 1 and X is —N(CH 2 CH 2 CH 2 CH 3 )—. 
     In another embodiment, n is 1 and X is —N(C(H)(CH 3 )(CH 2 CH 3 ))—. 
     In another embodiment, n is 1 and X is —N(C(H)(CH 3 ) 2 )—. 
     In another embodiment, n is 1 and X is —N(CH 2 C(H)(CH 3 ) 2 )—. 
     In another embodiment, n is 1 and X is —N(C(CH 3 ) 3 )—. 
     In one embodiment, one R 2  is —H, and the other R 2  is —C 1 -C 6  alkyl. 
     In another embodiment, each R 2  is —C 1 -C 6  alkyl. 
     In another embodiment, each R 2  is -methyl. 
     In various embodiments, —N(R 2 )(R 2 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In other embodiments, —N(R 2 )(R 2 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In some embodiments, —N(R 2 )(R 2 ) is 
     
       
         
         
             
             
         
       
     
     In still other embodiments, —N(R 2 )(R 2 ) is
         —N(CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ),   —NH—CH 2 CH 2 CH 2 CH 3 , or   —NH—CH 2 CH 2 —O—CH 3 .       

     In some embodiments, —N(R 2 )(R 2 ) is 
     
       
         
         
             
             
         
       
     
     In various embodiments, —N(Z 3 )(Z 4 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In other embodiments, —N(Z 3 )(Z 4 ) is: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In some embodiments, —N(Z 3 )(Z 4 ) is 
     
       
         
         
             
             
         
       
     
     In still other embodiments, —N(Z 3 )(Z 4 ) is
         —N(CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 3 )(CH 3 ),   —N(CH 2 CH 2 CH 2 CH 3 )(CH 3 ),   —NH—CH 2 CH 2 CH 2 CH 3 , or   —NH—CH 2 CH 2 —O—CH 3 .       

     In some embodiments, —N(Z 3 )(Z 4 ) is 
     
       
         
         
             
             
         
       
     
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; 
     n is an integer ranging from 1 to 3; 
     each R 2  is independently —H, —C 1 -C 6  alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —(C 1 -C 6  alkylene)-phenyl or -phenyl, each of which other than hydrogen is unsubstituted or substituted with one or more of -halo, —OH, —OP(O)(OH) 2 , —OS(O) 2 OH or —N(Z 3 )(Z 4 ), where Z 3  and Z 4  are independently —H, —C 1 -C 5  alkyl, or —(C 1 -C 5  alkylene)-O—C 1 -C 5  alkyl, each of which other than hydrogen is unsubstituted or substituted with one or more of -halo, —OH or —NH 2 ; 
     or N, Z 3  and Z 4  are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one to three of —C 1 -C 5  alkyl, -phenyl, —(C 1 -C 5  alkylene)-phenyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —C 1 -C 5  alkylene-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, or —C 1 -C 10  alkyl; 
     or N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one to three of —C 1 -C 5  alkyl, -phenyl, —(C 1 -C 5  alkylene)-phenyl, -(hydroxy-substituted) C 1 -C 5  alkyl, -halo, -(halo-substituted) C 1 -C 5  alkyl, -(halo-substituted) phenyl, -phenylene-O—C 1 -C 5  alkyl, -(cyano-substituted) phenyl, —OH, —O—C 1 -C 5  alkyl, —N(R a ) 2 , —(C 1 -C 5  alkylene)-N(R a ) 2 , —(C 1 -C 5  alkylene)-C(O)O—(C 1 -C 5  alkylene)-N(R a ) 2 , —COOH, —(C 1 -C 5  alkylene)-COOH, —OP(O)(OH) 2 , —OS(O) 2 OH, —(C 1 -C 5  alkylene)-OP(O)(OH) 2 , —(C 1 -C 5  alkylene)-OS(O) 2 OH, —C(O)O—C 1 -C 5  alkyl, —OC(O)—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)O—C 1 -C 5  alkyl, —(C 1 -C 5  alkylene)-C(O)NH—C 1 -C 5  alkyl, —C(O)NH 2 , or —NO 2 , wherein each occurrence of R a  is independently —H, -benzyl, or —C 1 -C 10  alkyl. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; 
     n is an integer ranging from 1 to 3; and 
     at least one C 1 -C 3  alkyl is methyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; at least one C 1 -C 3  alkyl is methyl; and at least one R 2  is ethyl. 
     In yet another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; at least one C 1 -C 3  alkyl is methyl; and at least one R 2  is propyl. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; at least one C 1 -C 3  alkyl is methyl; and at least one R 2  is —C 3 -C 8  monocyclic cycloalkyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; at least one C 1 -C 3  alkyl is methyl; and at least one R 2  is cyclohexyl. 
     In yet another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2 CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; and at least one C 1 -C 3  alkyl is methyl, wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle. 
     In one embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; and at least one C 1 -C 3  alkyl is methyl, wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with a hydroxyl. 
     In another embodiment, X is —N(CH 3 )—, —N(CH 2 CH 3 )—, —N(CH 2 CH 2 CH 3 )—, —N(CH 2  CH 2 CH 2 CH 3 )—, —N(C(H)(CH 3 )(CH 2 CH 3 ))—, —N(C(H)(CH 3 ) 2 )—, —N(CH 2 C(H)(CH 3 ) 2 — or —N(C(CH 3 ) 3 )—; and at least one C 1 -C 3  alkyl is methyl, wherein N and both R 2  groups are taken together to form a nitrogen-containing 3- to 7-membered monocyclic heterocycle, which is substituted with a nitrogen-containing 3- to 7-membered monocyclic heterocycle. 
     Illustrative examples of the Indenoisoquinolinone Analogs include the compounds of Formula (IVc) as set forth below: 
     
       
         
           
               
               
            
               
                   
               
               
                   
                 (IVc) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Compound 
                 —R 1   
                 X 
               
               
                   
               
               
                 IVb-1 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —O— 
               
               
                 IVc-2 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —CH 2 — 
               
               
                 IVc-3 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —C(O)— 
               
               
                 IVc-4 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —NH— 
               
               
                 IVc-5 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —S— 
               
               
                 IVc-6 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 3 )— 
               
               
                 IVc-7 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 3 )— 
               
               
                 IVc-8 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 IVc-9 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 IVc-10 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 IVc-11 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 IVc-12 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 IVc-13 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 IVc-14 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —CH(OH)— 
               
               
                 IVc-15 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 IVc-16 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 IVc-17 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 IVc-18 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —F)— 
               
               
                 IVc-19 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVc-20 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —CF 3 )— 
               
               
                 IVc-21 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVc-22 
                 —OC(Me)(Me)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 IVc-23 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —O— 
               
               
                 IVc-24 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —CH 2 — 
               
               
                 IVc-25 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —C(O)— 
               
               
                 IVc-26 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —NH— 
               
               
                 IVc-27 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —S— 
               
               
                 IVc-28 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 3 )— 
               
               
                 IVc-29 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 3 )— 
               
               
                 IVc-30 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 IVc-31 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 IVc-32 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 IVc-33 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 IVc-34 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 IVc-35 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 IVc-36 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —CH(OH)— 
               
               
                 IVc-37 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 IVc-38 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 IVc-39 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 IVc-40 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —F)— 
               
               
                 IVc-41 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVc-42 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —CF 3 )— 
               
               
                 IVc-43 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVc-44 
                 —OC(Me)(Et)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 IVc-45 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —O— 
               
               
                 IVc-46 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —CH 2 — 
               
               
                 IVc-47 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —C(O)— 
               
               
                 IVc-48 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —NH— 
               
               
                 IVc-49 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —S— 
               
               
                 IVc-50 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 3 )— 
               
               
                 IVc-51 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 3 )— 
               
               
                 IVc-52 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                 IVc-53 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                 IVc-54 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                 IVc-55 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                 IVc-56 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                 IVc-57 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(CH 3 ) 3 )— 
               
               
                 IVc-58 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —CH(OH)— 
               
               
                 IVc-59 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                 IVc-60 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                 IVc-61 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                 IVc-62 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —F)— 
               
               
                 IVc-63 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVc-64 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(CH 2 —CH 2 —CF 3 )— 
               
               
                 IVc-65 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                 IVc-66 
                 —OC(Me)(Pr)—CH 2 —N(Et)(Et) 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                 IVc-67 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —O— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-68 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —CH 2 — 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-69 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —C(O)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-70 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —NH— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-71 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —S— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-72 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-73 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 CH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-74 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 CH 2 CH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-75 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 CH 2 CH 2 CH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-76 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(H)(CH 3 )(CH 2 CH 3 ))— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-77 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(H)(CH 3 ) 2 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-78 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 C(H)(CH 3 ) 2 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-79 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(CH 3 ) 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-80 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —CH(OH)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-81 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(O)N(H)—CH 2 —CH 2 —OH)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-82 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(O)N(H)—CH 2 —CH 2 —F)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-83 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 —CH 2 —OH)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-84 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 —CH 2 —F)— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-85 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 —CH 2 —OCH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-86 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(CH 2 —CH 2 —CF 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-87 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(O)N(H)—CH 2 —CH 2 —OCH 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                 IVc-88 
                 —OC(Me)(i-Pr)—CH 2 — 
                 —N(C(O)N(H)—CH 2 —CH 2 —CF 3 )— 
               
               
                   
                 N(H)(cyclopropyl) 
               
               
                   
               
            
           
         
       
     
     and pharmaceutically acceptable salts thereof. 
     5.13 The Indenoisoquinolinone Analogs of Formula (Va) 
     The present invention provides Indenoisoquinolinone Analogs according to Formula (Va), below: 
                         
and pharmaceutically acceptable salts thereof,
 
wherein R 1 , X and Y′ are as defined above for the Indenoisoquinolinone Analogs of Formula (Va).
 
     In one embodiment, R 1  is —(CH 2 ) n —NHR 2  and R 2  is a —C 3 -C 8  monocyclic cycloalkyl. 
     In another embodiment, R 1  is —(CH 2 ) n —NHR 2  and R 2  is a —C 3 -C 8  monocyclic cycloalkyl substituted with one or more of -(hydroxy-substituted) C 1 -C 5  alkyl. 
     In one embodiment, R 1  is —(CH 2 ) n —NHR 2 , R 2  is a —C 3 -C 8  monocyclic cycloalkyl, and X is fluoro. 
     In one embodiment, R 1  is —(CH 2 ) n —NHR 2 , R 2  is a —C 3 -C 8  monocyclic cycloalkyl, and X is chloro. 
     In one embodiment, R 1  is —(CH 2 ) n —NHR 2  and R 2  is cyclopentyl. 
     In another embodiment, R 1  is —(CH 2 ) n —NHR 2 , R 2  is a —C 3 -C 8  monocyclic cycloalkyl substituted with one or more of -(hydroxy-substituted) C 1 -C 5  alkyl, and X is fluoro. 
     In another embodiment, R 1  is —(CH 2 ) n —NHR 2 , R 2  is cyclopentyl substituted with one or more of -(hydroxy-substituted C 1 -C 5  alkyl), and X is fluoro. 
     In one embodiment, R 1  is —(CH 2 ) n —NHR 2 , R 2  is a —C 3 -C 8  monocyclic cycloalkyl, and Y′ is fluoro. 
     In another embodiment, R 1  is —(CH 2 ) n —NHR 2 , R 2  is a —C 3 -C 8  monocyclic cycloalkyl substituted with one or more of -(hydroxy-substituted C 1 -C 5  alkyl), and Y′ is fluoro. 
     In another embodiment, R 1  is —(CH 2 ) n —NHR 2 , R 2  is a —C 3 -C 8  monocyclic cycloalkyl substituted with one or more of -(hydroxy-substituted) C 1 -C 5  alkyl, and X and Y′ are fluoro. 
     In another embodiment, R 1  is —(CH 2 ) n —NHR 2 , R 2  is a 3- to 7-membered monocyclic heterocycle, and X is fluoro. 
     In another embodiment, R 1  is —(CH 2 ) n —NHR 2 , R 2  is a 3- to 7-membered monocyclic heterocycle, and Y′ is fluoro. 
     In another embodiment, R 1  is —(CH 2 ) n —NHR 2  and R 2  is tetrahydropyranyl. 
     In one embodiment, R 2  is tetrahydropyranyl, or cyclopentyl which is unsubstituted or substituted with one or more of -(hydroxy-substituted C 1 -C 5  alkyl). 
     In another embodiment, one of X and Y′ is fluoro. 
     Illustrative examples of the Indenoisoquinolinone Analogs include the compounds of Formula (Va) as set forth below: 
     
       
         
           
               
               
            
               
                   
               
               
                   
                 (Va) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Compound 
                 —R 1   
                 X 
                 Y&#39; 
               
               
                   
               
               
                 Va-1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —Cl, at position 4 
                 —H 
               
               
                   
               
               
                 Va-2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —F, at position 2 
                 —H 
               
               
                   
               
               
                 Va-3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —F, at position 3 
                 —H 
               
               
                   
               
               
                 Va-4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —F, at position 4 
                 —H 
               
               
                   
               
               
                 Va-5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —F, at position 3 
                 —H 
               
               
                   
               
               
                 Va-6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —F, at position 1 
                 —H 
               
               
                   
               
               
                 Va-7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —F, at position 1 
                 —H 
               
               
                   
               
               
                 Va-8 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —F, at position 2 
                 —H 
               
               
                   
               
               
                 Va-9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —H 
                 —F, at position 8 
               
               
                   
               
               
                 Va-10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 —F, at position 3 
                 —F, at position 8 
               
               
                   
               
            
           
         
       
     
     5.14 Methods for Making Indenoisoquinolinone Analogs 
     Methods useful for making the Indenoisoquinolinone Analogs are set forth in the Examples below and generalized in Schemes 1-7. 
                         
wherein n and each R 2  is defined above for the Indenoisoquinolinone Analogs of Formula (IIa), (IIb), (IIc), (IIIa), (IIIb), (IVa), (IVb) or (IVc), and X is —Br, —I, —Cl, —O-Ts, —O-Ms, —O-Triflate, or —O-Acetate.
 
     As shown in Scheme 1, a compound of formula 1 can be reacted with methanol in the presence of an acid, for example, sulphuric acid, to provide a compound of formula 2. The compound of formula 2 can then be reacted with cyanide to provide a compound of formula 3. The compound of formula 3 can be brominated using, for example, N-bromosuccinimide, to provide a compound of formula 4. The compound of formula 4 can then be reacted with homophthalic anhydride to provide a compound of formula 5. The compound of formula 5 can then be reduced, for example with lithium aluminum hydride (LAH), to provide a compound of formula 6. 
     
       
         
         
             
             
         
       
     
     As shown in Scheme 2, an indenoisoquinolinone compound of formula 8 can be reacted with hydrochloric acid or hydrobromic acid in the presence of formaldehyde to provide a halomethyl compound of formula 9. The compound of formula 9 can then be reacted with an amine of formula NH(R 2 )(R 3 ) to provide an Indenoisoquinolinone Analog of Formula (IIb), wherein R 1 =—(CH 2 )—N(R 2 )(R 3 ), wherein each R 2  and R 3  are as defined above. Alternatively, the compound of formula 9 can be reacted with an appropriate amine to provide an Indenoisoquinolinone Analog of Formula (IIIb) or (IVb). 
     A compound of formula 6 can be reacted with a reagent 6a to provide a compound of formula 7 (see, e.g., Scheme 1). Suitable reagents 6a include, but are not limited to, PBr 3 , HBr, HI, SOCl 2 , Ts-Cl, pyrene, MsCl, CF 3 SO 2 Cl, acetic anhydride, acetyl chloride or NEt 3 . The compound of formula 7 can then be reacted with an amine of formula NH(R 2 )(R 3 ) to provide an Indenoisoquinolinone Analog of Formula (IIa), (IIb) or (IIc) wherein R 1 =—(CH 2 ) n —N(R 2 )(R 3 ), wherein n, R 2  and R 3  are as defined above. Alternatively, the compound of formula 7 can be reacted with an appropriate amine to provide an Indenoisoquinolinone Analog of Formula (IIIa) or (IIIb). Using similar methods, Indenoisoquinolinone Analogs of Formula (IVa), (IVb) or (IVc) can also be obtained using an appropriate analog of the compound of formula 1, as would be apparent to one of ordinary skill in the art. 
                         
wherein n is defined above for the Indenoisoquinolinone Analogs of Formula (Ia), (Ib), (Ic), (IIa), (IIIb) or (IIc) and X′ is —OH, —SH, —NHC(O)OMe, or —N(C 1 -C 4  alkyl). As set forth in Scheme 3, a compound of formula 10 is reacted with a compound of formula 11 in the presence of triethylamine to provide a compound of formula 12, wherein X is —O—, —S—, —N(C(O)OMe)-, or —N(C 1 -C 4  alkyl)-. The compound of formula 12 can then be converted to provide an Indenoisoquinolinone Analog of Formula (Ia), (Ib), (Ic), (Ia), (IIb) or (IIc), e.g., using procedures outlined in Scheme 1 and/or 2. The compound of formula 12, wherein X is —N(C(O)OMe)-, can be deprotected, for example using hydrazine, to provide a compound, wherein X is —N(H)—. Using similar methods, Indenoisoquinolinone Analogs of Formula (IVa), (IVb) or (IVc) can also be obtained using an appropriate analog of the compound of formula 1, as would be apparent to one of ordinary skill in the art.
 
                         
wherein X′ is —OH, —SH, or NHC(O)OMe or —N(C 1 -C 4  alkyl).
 
     As set forth in Scheme 4, a compound of formula 13 is reacted with a compound of formula 11, to provide a compound of formula 14, wherein X is —O—, —S—, —N(C(O)OMe)-, or —N(C 1 -C 4  alkyl)-. The compound of formula 14 is then converted to provide an Indenoisoquinolinone Analog of Formula (Ia), (Ib), (Ic), wherein R 1 =−O—(CH 2 ) m —N(R 2 )(R 2 ) or an Indenoisoquinolinone Analog of Formula (IVa), (IVb) or (IVc), for example using methods described in Schemes 1 and/or 5. 
                         
wherein X, m, n, each R 2  and each C 1 -C 3  alkyl is defined above for the Indenoisoquinolinone Analogs of Formula (Ia), (Ib), (Ic), (IVa), (IVb) or (IVc) and A is a halogen.
 
     As set forth in Scheme 5, a compound of formula 14 is demethylated, for example using boron tribromide, to provide a compound of formula 15. A compound of formula 15 is then reacted in the presence of base with A(CH 2 ) m NR 2 R 2  to provide the compound of the general formula 15a, an Indenoisoquinolinone Analog of Formula (Ia), (Ib), or (Ic), wherein R 1 =—O—(CH 2 ) m —N(R 2 )(R 2 ). Alternatively, a compound of formula 15 is reacted in the presence of base with A-C(C 1 -C 3  alkyl) 2 (CH 2 ) n NR 2 R 2  to provide the compound of the general formula 15b, an Indenoisoquinolinone Analog of Formula (IVa), (IVb), or (IVc). 
                         
wherein R 1  is as defined above for the Indenoisoquinolinone Analogs of Formula (IIa), (IIb), (IIc), (IVa), (IVb) or (IVc).
 
     As set forth in Scheme 6, compounds of the general formula 16, which can be prepared, for example, according to Schemes 1 or 2, can be oxidized to provide a compound of the general formula 17, which is an Indenoisoquinolinone Analog of Formula (IIa), (IIb), (IIc), (IVa), (IVb) or (IVc), wherein X is —C(O)—. In one embodiment, the oxidation is achieved using O 2  and dimethylsulfoxide. In one aspect, the O 2  is that which is present in air. In another embodiment, the oxidation is achieved using Cerium(IV) triflate (Ce(OTf) 4 ). Optional protecting groups can be used (Greene et al.,  Protective Groups in Organic Synthesis  (3 rd  ed. 1999)). For example, where R 1  is —(CH 2 ) n —OH, protecting groups such as —SiEt 3 , can be used to protect the R 1  hydroxyl group during the oxidation and can then be removed, for example with an acid. The compound of the general formula 17, can be reduced, for example with sodium borohydride or lithium aluminum hydride, to provide the compound of the general formula 18, which is an Indenoisoquinolinone Analog of Formula (IIa), (IIb), (IIc), (IVa), (IVb) or (IVc), wherein X is —CH(OH)—. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     As set forth in Scheme 7, Indenoisoquinolinone Analogs of Formula (Va) can be prepared, for example, as illustrated in part (1) of the scheme by reacting compound 19 with either compounds 20 or 23 to yield compounds 21 and 24, respectively. Compounds 21 and 24 can then be reacted with the selected amine to form compounds 22 and 25 respectively. Compounds 22 and 25 are representative of an Indenoisoquinolinone Analog of Formula (Va). In part (2) of the scheme, reaction of compound 26 under suitable conditions and in the presence of homophthalic anhydride and the desired amine yields compound 27, which is an Indenoisoquinolinone Analog of Formula of Formula (Va). 
     5.15 Treatment or Prevention of a Condition 
     In accordance with the invention, an Indenoisoquinolinone Analog is useful for treatment or prevention of a Condition as set forth below. 
     5.8.1 Treatment or Prevention of an Inflammatory Disease 
     The Indenoisoquinolinone Analogs are useful for treating or preventing an inflammatory disease. An inflammatory disease can arise where there is an inflammation of the body tissue. These include local inflammatory responses and systemic inflammation. Examples of inflammatory diseases include, but are not limited to, lupus; pancreatitis; macular degeneration; chronic obstructive pulmonary disease; organ transplant rejection; a chronic inflammatory disease of a joint, including arthritis, rheumatoid arthritis, osteoarthritis and a bone disease associated with increased bone resorption; an inflammatory bowel disease such as ileitis, ulcerative colitis, Barrett&#39;s syndrome, and Crohn&#39;s disease; an inflammatory lung disease such as asthma, adult respiratory distress syndrome, and chronic obstructive airway disease; an inflammatory disease of the eye including corneal dystrophy, trachoma, onchocerciasis, uveitis, sympathetic ophthalmitis and endophthalmitis; a chronic inflammatory disease of the gum, including gingivitis and periodontitis; tuberculosis; leprosy; an inflammatory disease of the kidney including a uremic complication, glomerulonephritis and nephrosis; an inflammatory disease of the skin including sclerodermatitis, psoriasis and eczema; an inflammatory disease of the central nervous system, including a chronic demyelinating disease of the nervous system, multiple sclerosis, AIDS-related neurodegeneration and Alzheimer&#39;s disease, infectious meningitis, encephalomyelitis, Huntington&#39;s disease, amyotrophic lateral sclerosis and viral or autoimmune encephalitis; as well as any other disease that can have a significant inflammatory component, including preeclampsia, chronic liver failure, and brain and spinal cord trauma. The inflammatory disease can also be a systemic inflammation of the body, exemplified by gram-positive or gram negative shock, hemorrhagic or anaphylactic shock, or shock induced by cancer chemotherapy in response to pro-inflammatory cytokines, e.g., shock associated with pro-inflammatory cytokines. Such shock can be induced, e.g., by a chemotherapeutic agent that is administered as a treatment for cancer. 
     In one embodiment, the inflammatory disease is an inflammatory disease of a joint, a chronic inflammatory disease of the gum, an inflammatory bowel disease, an inflammatory lung disease, an inflammatory disease of the central nervous system, an inflammatory disease of the eye, gram-positive shock, gram negative shock, Rickettsial shock, fungal shock, hemorrhagic shock, anaphylactic shock, traumatic shock or chemotherapeutic shock. 
     5.8.2 Treatment or Prevention of a Reperfusion Injury 
     The Indenoisoquinolinone Analogs are useful for treating or preventing a reperfusion injury. Reperfusion refers to the process whereby blood-flow in the blood vessels is resumed following ischemia, such as occurs following constriction or obstruction of the vessel. Reperfusion injury can result following a naturally occurring episode, such as a myocardial infarction, stroke, or during a surgical procedure where blood flow in vessels is intentionally or unintentionally blocked. Examples of reperfusion injuries include, but are not limited to, intestinal reperfusion injury, myocardial reperfusion injury, and reperfusion injury resulting from cardiopulmonary bypass surgery, aortic aneurysm repair surgery, carotid endarterectomy surgery, and hemorrhagic shock. 
     In one embodiment, the reperfusion injury results from cardiopulmonary bypass surgery, aortic aneurysm repair surgery, carotid endarterectomy surgery or hemorrhagic shock. 
     In another embodiment, the reperfusion injury is stroke or myocardial infarction. 
     5.8.3 Treatment or Prevention of Reoxygenation Injury Resulting from Organ Transplantation 
     The Indenoisoquinolinone Analogs are useful for treating or preventing reoxygenation injury resulting from organ transplantation. Examples of reoxygenation injuries include, but are not limited to, transplantation of one or more of the following: heart, lung, liver, kidney, pancreas, intestine and cornea. 
     In one embodiment, reoxygenation injury resulting from organ transplantation occurs during the organ transplantation. 
     The Indenoisoquinolinone Analogs are also useful for treating or preventing allograph rejection. Accordingly, the invention provides methods for treating or preventing allograph rejection, comprising administering an effective amount of an Indenoisoquinolinone Analog to a subject in need thereof. In one embodiment, the methods further comprise administering an effective amount of another agent useful for treating or preventing allograph rejection. The other agent includes, but is not limited to, SK-506 and cyclosporine. 
     5.8.4 Treatment or Prevention of an Ischemic Condition 
     The Indenoisoquinolinone Analogs are useful for treating or preventing an ischemic condition. Examples of ischemic conditions include, but are not limited to, stable angina, unstable angina, myocardial ischemia, hepatic ischemia, mesenteric artery ischemia, ischemic heart disease, intestinal ischemia, critical limb ischemia, chronic critical limb ischemia, cerebral ischemia, acute cardiac ischemia, and an ischemic disease of the central nervous system, such as stroke or cerebral ischemia. 
     In one embodiment, the ischemic condition is myocardial ischemia, stable angina, unstable angina, stroke, ischemic heart disease or cerebral ischemia. 
     5.8.5 Treatment or Prevention of Renal Failure 
     The Indenoisoquinolinone Analogs are useful for treating or preventing renal failure. 
     In one embodiment, the renal failure is chronic renal failure. 
     In another embodiment, the renal failure is acute renal failure. 
     5.8.6 Treatment or Prevention of a Vascular Disease 
     The Indenoisoquinolinone Analogs are useful for treating or preventing a vascular disease other than a cardiovascular disease. Examples of vascular diseases include, but are not limited to, hemorrahgic stroke, peripheral arterial occlusion, thromboangitis obliterans, Reynaud&#39;s disease and phenomenon, acrocyanosis, erythromelalgia, venous thrombosis, varicose veins, arteriovenous fistula, lymphedema, and lipedema. 
     In embodiment, the vascular disease is peripheral arterial occlusion, thromboangitis obliterans, Reynaud&#39;s disease and phenomenon, acrocyanosis, erythromelalgia, venous thrombosis, varicose veins, arteriovenous fistula, lymphedema or lipedema. 
     5.8.7 Treatment or Prevention of a Cardiovascular Disease 
     The Indenoisoquinolinone Analogs are useful for treating or preventing a cardiovascular disease. Examples of cardiovascular diseases include, but are not limited to, congestive heart failure (such as chronic or acute heart failure), atherosclerosis, hypercholesterolemia, circulatory shock, cardiomyopathy, cardiac transplant, myocardial infarction, and a cardiac arrhythmia, such as atrial fibrillation, supraventricular tachycardia, atrial flutter, and paroxysmal atrial tachycardia. 
     In one embodiment, the cardiovascular disease is chronic heart failure. 
     In another embodiment, the cardiovascular disease is acute heart failure. 
     In yet another embodiment, the cardiovascular disease is cardiac arrhythmia. 
     In still another embodiment, the cardiac arrhythmia is atrial fibrillation, supraventricular tachycardia, atrial flutter or paroxysmal atrial tachycardia. 
     In one embodiment, the cardiovascular disease is chronic heart failure, atrial fibrillation, supraventricular tachycardia, atrial flutter or paroxysmal atrial tachycardia. 
     5.8.8 Treatment or Prevention of Diabetes Mellitus or a Diabetic Complication 
     The Indenoisoquinolinone Analogs are useful for treating or preventing diabetes mellitus or one or more of its complications. Examples of diabetes mellitus include, but are not limited to, Type I diabetes (Insulin Dependent Diabetes Mellitus), Type II diabetes (Non-Insulin Dependent Diabetes Mellitus), gestational diabetes, autoimmune diabetes, insulinopathies, diabetes due to pancreatic disease, diabetes associated with other endocrine diseases (such as Cushing&#39;s Syndrome, acromegaly, pheochromocytoma, glucagonoma, primary aldosteronism or somatostatinoma), Type A insulin resistance syndrome, Type B insulin resistance syndrome, lipatrophic diabetes, and diabetes induced by β-cell toxins. 
     The Indenoisoquinolinone Analogs are useful for treating or preventing a complication of diabetes mellitus. Examples of complications of diabetes mellitus include, but are not limited to, diabetic cataract, glaucoma, retinopathy, nephropathy (such as microalbuminuria or progressive diabetic nephropathy), polyneuropathy, gangrene of the feet, immune-complex vasculitis, systemic lupus erythematosus (SLE), atherosclerotic coronary arterial disease, peripheral arterial disease, nonketotic hyperglycemic-hyperosmolar coma, mononeuropathies, autonomic neuropathy, foot ulcers, joint problems, and a skin or mucous membrane complication (such as an infection, a shin spot, a candidal infection or necrobiosis lipoidica diabeticorumobesity), hyperlipidemia, hypertension, syndrome of insulin resistance, coronary artery disease, retinopathy, neuropathy (such as diabetic neuropathy, polyneuropathy or mononeuropathy), autonomic neuropathy, a foot ulcer, a joint problem, a fungal infection, cardiomyopathy, and a bacterial infection. 
     In one embodiment diabetes mellitus is Type I diabetes mellitus or Type II diabetes mellitus. 
     5.8.9 Treatment or Prevention of a Neurodegenerative Disease 
     The Indenoisoquinolinone Analogs are useful for treating or preventing a neurodegenerative disease. Examples of neurodegenerative diseases include, but are not limited to, Alzheimer&#39;s disease, Parkinson&#39;s disease and amyotrophic lateral sclerosis. 
     5.8.10 Treatment or Prevention of Cancer 
     The Indenoisoquinolinone Analogs are useful for treating or preventing cancer. 
     Accordingly, the invention provides methods for treating or preventing cancer, comprising administering an effective amount of an Indenoisoquinolinone Analog to a subject in need thereof. In one embodiment, the methods further comprise administering an effective amount of another anticancer agent. 
     Examples of cancers include, but are not limited to, the cancers disclosed below in Table 1 and metastases thereof. 
     
       
         
           
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
             
            
               
                   
                 Solid tumors, including but not limited to: 
                   
               
               
                   
                 fibrosarcoma 
                   
               
               
                   
                 myxosarcoma 
                   
               
               
                   
                 liposarcoma 
                   
               
               
                   
                 chondrosarcoma 
                   
               
               
                   
                 osteogenic sarcoma 
                   
               
               
                   
                 chordoma 
                   
               
               
                   
                 angiosarcoma 
                   
               
               
                   
                 endotheliosarcoma 
                   
               
               
                   
                 lymphangiosarcoma 
                   
               
               
                   
                 lymphangioendotheliosarcoma 
                   
               
               
                   
                 synovioma 
                   
               
               
                   
                 mesothelioma 
                   
               
               
                   
                 Ewing&#39;s tumor 
                   
               
               
                   
                 leiomyosarcoma 
                   
               
               
                   
                 rhabdomyosarcoma 
                   
               
               
                   
                 colon cancer 
                   
               
               
                   
                 colorectal cancer 
                   
               
               
                   
                 kidney cancer 
                   
               
               
                   
                 pancreatic cancer 
                   
               
               
                   
                 bone cancer 
                   
               
               
                   
                 breast cancer 
                   
               
               
                   
                 ovarian cancer 
                   
               
               
                   
                 prostate cancer 
                   
               
               
                   
                 esophageal cancer 
                   
               
               
                   
                 stomach cancer 
                   
               
               
                   
                 oral cancer 
                   
               
               
                   
                 nasal cancer 
                   
               
               
                   
                 throat cancer 
                   
               
               
                   
                 squamous cell carcinoma 
                   
               
               
                   
                 basal cell carcinoma 
                   
               
               
                   
                 adenocarcinoma 
                   
               
               
                   
                 sweat gland carcinoma 
                   
               
               
                   
                 sebaceous gland carcinoma 
                   
               
               
                   
                 papillary carcinoma 
                   
               
               
                   
                 papillary adenocarcinomas 
                   
               
               
                   
                 cystadenocarcinoma 
                   
               
               
                   
                 medullary carcinoma 
                   
               
               
                   
                 bronchogenic carcinoma 
                   
               
               
                   
                 renal cell carcinoma 
                   
               
               
                   
                 hepatoma 
                   
               
               
                   
                 bile duct carcinoma 
                   
               
               
                   
                 choriocarcinoma 
                   
               
               
                   
                 seminoma 
                   
               
               
                   
                 embryonal carcinoma 
                   
               
               
                   
                 Wilms&#39; tumor 
                   
               
               
                   
                 cervical cancer 
                   
               
               
                   
                 uterine cancer 
                   
               
               
                   
                 testicular cancer 
                   
               
               
                   
                 small cell lung carcinoma 
                   
               
               
                   
                 bladder carcinoma 
                   
               
               
                   
                 lung cancer 
                   
               
               
                   
                 epithelial carcinoma 
                   
               
               
                   
                 skin cancer 
                   
               
               
                   
                 melanoma 
                   
               
               
                   
                 metastatic melanoma 
                   
               
               
                   
                 neuroblastoma 
                   
               
               
                   
                 retinoblastoma 
                   
               
               
                   
                 blood-borne cancers, including but not limited to: 
                   
               
               
                   
                 acute lymphoblastic leukemia (“ALL”) 
                   
               
               
                   
                 acute lymphoblastic B-cell leukemia 
                   
               
               
                   
                 acute lymphoblastic T-cell leukemia 
                   
               
               
                   
                 acute myeloblastic leukemia (“AML”) 
                   
               
               
                   
                 acute promyelocytic leukemia (“APL”) 
                   
               
               
                   
                 acute monoblastic leukemia 
                   
               
               
                   
                 acute erythroleukemic leukemia 
                   
               
               
                   
                 acute megakaryoblastic leukemia 
                   
               
               
                   
                 acute myelomonocytic leukemia 
                   
               
               
                   
                 acute nonlymphocyctic leukemia 
                   
               
               
                   
                 acute undifferentiated leukemia 
                   
               
               
                   
                 chronic myelocytic leukemia (“CML”) 
                   
               
               
                   
                 chronic lymphocytic leukemia (“CLL”) 
                   
               
               
                   
                 hairy cell leukemia 
                   
               
               
                   
                 multiple myeloma 
                   
               
               
                   
                 acute and chronic leukemias: 
                   
               
               
                   
                 lymphoblastic 
                   
               
               
                   
                 myelogenous 
                   
               
               
                   
                 lymphocytic 
                   
               
               
                   
                 myelocytic leukemias 
                   
               
               
                   
                 Lymphomas: 
                   
               
               
                   
                 Hodgkin&#39;s disease 
                   
               
               
                   
                 non-Hodgkin&#39;s Lymphoma 
                   
               
               
                   
                 Multiple myeloma 
                   
               
               
                   
                 Waldenström&#39;s macroglobulinemia 
                   
               
               
                   
                 Heavy chain disease 
                   
               
               
                   
                 Polycythemia vera 
                   
               
               
                   
                 Central nervous system lymphomas 
                   
               
               
                   
                 CNS and Brain cancers: 
                   
               
               
                   
                 glioma 
                   
               
               
                   
                 pilocytic astrocytoma 
                   
               
               
                   
                 astrocytoma 
                   
               
               
                   
                 anaplastic astrocytoma 
                   
               
               
                   
                 glioblastoma multiforme 
                   
               
               
                   
                 medulloblastoma 
                   
               
               
                   
                 craniopharyngioma 
                   
               
               
                   
                 ependymoma 
                   
               
               
                   
                 pinealoma 
                   
               
               
                   
                 hemangioblastoma 
                   
               
               
                   
                 acoustic neuroma 
                   
               
               
                   
                 oligodendroglioma 
                   
               
               
                   
                 meningioma 
                   
               
               
                   
                 vestibular schwannoma 
                   
               
               
                   
                 adenoma 
                   
               
               
                   
                 metastatic brain tumor 
                   
               
               
                   
                 meningioma 
                   
               
               
                   
                 spinal tumor 
                   
               
               
                   
                 medulloblastoma 
               
               
                   
               
            
           
         
       
     
     In one embodiment, the cancer is lung cancer, breast cancer, colorectal cancer, prostate cancer, a leukemia, a lymphoma, non-Hodgkin&#39;s lymphoma, skin cancer, a brain cancer, a cancer of the central nervous system, ovarian cancer, uterine cancer, stomach cancer, pancreatic cancer, esophageal cancer, kidney cancer, liver cancer, or a head and neck cancer. 
     In another embodiment, the cancer is metastatic cancer. 
     In yet another embodiment, the cancer is brain cancer or melanoma. 
     In one embodiment, the brain cancer is metastatic brain cancer or a glioma. 
     In one embodiment, the glioma is pilocytic astrocytoma, astrocytoma, anaplastic astrocytoma or glioblastoma multiforme. 
     In one embodiment, the cancer is homologous-recombination deficient, such as BRCA-1 or BRCA-2 deficient, or is deficient in one or more proteins of the Fanconi family. In one embodiment, the deficiency is caused by a genetic mutation. In another embodiment, the phenotype resulting from the deficiency is caused by abnormally low expression of BRCA-1 or BRCA-2 protein. In another embodiment, the phenotype resulting from the deficiency is caused by abnormally low expression of one or more proteins of the Fanconi family. 
     In still another embodiment, the subject in need of treatment has previously undergone or is presently undergoing treatment for cancer. The treatment includes, but is not limited to, chemotherapy, radiation therapy, surgery or immunotherapy, such as administration of a cancer vaccine. 
     The Indenoisoquinolinone Analogs are also useful for treating or preventing a cancer caused by a virus. Such viruses include human papilloma virus, which can lead to cervical cancer (see, e.g., Hernandez-Avila et al., Archives of Medical Research (1997) 28:265-271); Epstein-Barr virus (EBV), which can lead to lymphoma (see, e.g., Herrmann et al., J Pathol (2003) 199(2):140-5); hepatitis B or C virus, which can lead to liver carcinoma (see, e.g., El-Serag, J Clin Gastroenterol (2002) 35(5 Suppl 2):S72-8); human T cell leukemia virus (HTLV)-I, which can lead to T-cell leukemia (see e.g., Mortreux et al., Leukemia (2003) 17(1):26-38); human herpesvirus-8 infection, which can lead to Kaposi&#39;s sarcoma (see, e.g., Kadow et al., Curr Opin Investig Drugs (2002) 3(11):1574-9); and Human Immune deficiency Virus (HIV) infection, which can lead to cancer as a consequence of immunodeficiency (see, e.g., Dal Maso et al., Lancet Oncol (2003) 4(2):110-9). 
     5.8.10.1 Prophylactic Methods for Cancer 
     The Indenoisoquinolinone Analogs are also useful for preventing cancer, or preventing progression of a cancer, including but not limited to the cancers listed in Table 1. Such prophylactic use includes that in which non-neoplastic cell growth such as hyperplasia, metaplasia, or most specifically, dysplasia has occurred. 
     Alternatively or in addition to the presence of abnormal cell growth characterized as hyperplasia, metaplasia, or dysplasia, the presence of one or more characteristics of a transformed phenotype, or of a malignant phenotype, displayed in vivo or displayed in vitro by a cell sample from a subject, can indicate the desirability of prophylactic or therapeutic administration of an Indenoisoquinolinone Analog. Such characteristics of a transformed phenotype include morphology changes, looser substratum attachment, loss of contact inhibition, loss of anchorage dependence, protease release, increased sugar transport, decreased serum requirement, expression of fetal antigens, disappearance of the 250,000 dalton cell surface protein, etc. (see also id., at pp. 84-90 for characteristics associated with a transformed or malignant phenotype). 
     In a specific embodiment, leukoplakia, a benign-appearing hyperplastic or dysplastic lesion of the epithelium, or Bowen&#39;s disease, a carcinoma in situ, is treatable or preventable according to the present methods. 
     In another embodiment, fibrocystic disease (cystic hyperplasia, mammary dysplasia, specifically adenosis (benign epithelial hyperplasia)) is treatable or preventable according to the present methods. 
     In other embodiments, a subject that has one or more of the following predisposing factors for malignancy can be treated by administration of an effective amount of an 
     Indenoisoquinolinone Analog: a chromosomal translocation associated with a malignancy (e.g., the Philadelphia chromosome for chronic myelogenous leukemia; t(14; 18) for follicular lymphoma); familial polyposis or Gardner&#39;s syndrome; benign monoclonal gammopathy; a first degree kinship with persons having a cancer or precancerous disease showing a Mendelian (genetic) inheritance pattern (e.g., familial polyposis of the colon, Gardner&#39;s syndrome, hereditary exostosis, polyendocrine adenomatosis, medullary thyroid carcinoma with amyloid production and pheochromocytoma, Peutz-Jeghers syndrome, neurofibromatosis of Von Recklinghausen, retinoblastoma, carotid body tumor, cutaneous melanocarcinoma, intraocular melanocarcinoma, xeroderma pigmentosum, ataxia telangiectasia, Chediak-Higashi syndrome, albinism, Fanconi&#39;s aplastic anemia, and Bloom&#39;s syndrome); and exposure to carcinogens (e.g., smoking, second-hand smoke exposure, and inhalation of or contacting with certain chemicals). 
     5.8.10.2 Combination Chemotherapy for the Treatment of Cancer 
     In one aspect, the present methods for treating or preventing cancer can further comprise the administration of another anticancer agent. 
     In one embodiment, the present invention provides methods for treating or preventing cancer, comprising the administration of an effective amount of an Indenoisoquinolinone Analog and another anticancer agent to a subject in need thereof. 
     The Indenoisoquinolinone Analog and another anticancer agent can be administered concurrently. In this embodiment, the Indenoisoquinolinone Analog and another anticancer agent can be administered within the same composition, or can be administered from different compositions, via the same or different routes of administration. 
     In another embodiment, the Indenoisoquinolinone Analog is administered during a time when the other anticancer agent exerts its prophylactic or therapeutic effect, or vice versa. 
     In another embodiment, the Indenoisoquinolinone Analog or other anticancer agent are administered in doses commonly employed when such agents are used as monotherapy for the treatment of cancer. 
     In one embodiment, the Indenoisoquinolinone Analog or other anticancer agent are administered in doses that are lower than the doses commonly employed when such agents are used as monotherapy for the treatment of cancer. 
     In another embodiment, the Indenoisoquinolinone Analog and other anticancer agent act synergistically and are administered in doses that are lower than the doses commonly employed when such agents are used as monotherapy for the treatment of cancer. 
     The dosage of the Indenoisoquinolinone Analog or other anticancer agent administered as well as the dosing schedule can depend on various parameters, including, but not limited to, the cancer being treated, the subject&#39;s general health, and the administering physician&#39;s discretion. 
     An Indenoisoquinolinone Analog can be administered prior to (e.g., 5 minutes, 15 minutes, 30 minutes, 45 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 8 weeks, or 12 weeks before), concurrently with, or subsequent to (e.g., 5 minutes, 15 minutes, 30 minutes, 45 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 8 weeks, or 12 weeks after) the administration of the other anticancer agent, to a subject in need thereof. In various embodiments an Indenoisoquinolinone Analog and the other anticancer agent are administered 1 minute apart, 10 minutes apart, 30 minutes apart, less than 1 hour apart, 1 hour apart, 1 hour to 2 hours apart, 2 hours to 3 hours apart, 3 hours to 4 hours apart, 4 hours to 5 hours apart, 5 hours to 6 hours apart, 6 hours to 7 hours apart, 7 hours to 8 hours apart, 8 hours to 9 hours apart, 9 hours to 10 hours apart, 10 hours to 11 hours apart, 11 hours to 12 hours apart, no more than 24 hours apart or no more than 48 hours apart. In one embodiment, an Indenoisoquinolinone Analog and the other anticancer agent are administered within 3 hours. In another embodiment, an Indenoisoquinolinone Analog and the other anticancer agent are administered at 1 minute to 24 hours apart. 
     In one embodiment, an effective amount of an Indenoisoquinolinone Analog and an effective amount of other anticancer agent are present in the same composition. In one embodiment, this composition is useful for oral administration. In another embodiment, this composition is useful for intravenous administration. 
     In one embodiment, the compositions comprise an amount of an Indenoisoquinolinone Analog and the other anticancer agent which together are effective to treat or prevent cancer. 
     In another embodiment, the compositions comprise an effective amount of temozolomide, procarbazine, dacarbazine, interleukin-2, irinotecan, or doxorubicin, a physiologically acceptable carrier or vehicle, and an effective amount of an Indenoisoquinolinone Analog. 
     In one embodiment, the amount of an Indenoisoquinolinone Analog and the other anticancer agent is at least about 0.01% of the combined combination chemotherapy agents by weight of the composition. When intended for oral administration, this amount can be varied from about 0.1% to about 80% by weight of the composition. Some oral compositions can comprise from about 4% to about 50% of combined amount of an Indenoisoquinolinone Analog and the other anticancer agent by weight of the composition. Other compositions of the present invention are prepared so that a parenteral dosage unit contains from about 0.01% to about 2% by weight of the composition. 
     Cancers that can be treated or prevented by administering an Indenoisoquinolinone Analog and the other anticancer agent include, but are not limited to, the list of cancers set forth above in Table 1. 
     In one embodiment, the cancer is brain cancer. 
     In specific embodiments, the brain cancer is pilocytic astrocytoma, astrocytoma, anaplastic astrocytoma, glioblastoma multiforme or a metastatic brain tumor. 
     In one embodiment, the cancer is melanoma. 
     In a specific embodiment, the melanoma is metastatic melanoma. 
     The Indenoisoquinolinone Analog and other anticancer agent can act additively or synergistically. A synergistic combination of an Indenoisoquinolinone Analog and the other anticancer agent, might allow the use of lower dosages of one or both of these agents and/or less frequent administration of the agents to a subject with cancer. The ability to utilize lower dosages of one or both of the Indenoisoquinolinone Analog and other anticancer agent and/or to administer the agents less frequently can reduce any toxicity associated with the administration of the agents to a subject without reducing the efficacy of the agents in the treatment of cancer. In addition, a synergistic effect might result in the improved efficacy of these agents in the treatment of cancer and/or the reduction of any adverse or unwanted side effects associated with the use of either agent alone. 
     In one embodiment, the administration of an effective amount of an Indenoisoquinolinone Analog and an effective amount of another anticancer agent inhibits the resistance of a cancer to the other anticancer agent. In one embodiment, the cancer is a tumor. 
     Suitable other anticancer agents useful in the methods and compositions of the present invention include, but are not limited to temozolomide, a topoisomerase I inhibitor, procarbazine, dacarbazine, gemcitabine, capecitabine, methotrexate, taxol, taxotere, mercaptopurine, thioguanine, hydroxyurea, cytarabine, cyclophosphamide, ifosfamide, nitrosoureas, cisplatin, carboplatin, mitomycin, dacarbazine, procarbizine, etoposide, teniposide, campathecins, bleomycin, doxorubicin, idarubicin, daunorubicin, dactinomycin, plicamycin, mitoxantrone, L-asparaginase, doxorubicin, epirubicin, 5-fluorouracil, taxanes such as docetaxel and paclitaxel, leucovorin, levamisole, irinotecan, estramustine, etoposide, nitrogen mustards, BCNU, nitrosoureas such as carmustine and lomustine, vinca alkaloids such as vinblastine, vincristine and vinorelbine, platinum complexes such as cisplatin, carboplatin and oxaliplatin, imatinib mesylate, hexamethylmelamine, topotecan, tyrosine kinase inhibitors, tyrphostins herbimycin A, genistein, erbstatin, and lavendustin A. 
     In one embodiment, the other anticancer agent is, but is not limited to, a drug listed in Table 2. 
     
       
         
           
               
               
             
               
                 TABLE 2 
               
               
                   
               
             
            
               
                 Alkylating agents 
                   
               
               
                 Nitrogen mustards: 
                 Cyclophosphamide 
               
               
                   
                 Ifosfamide 
               
               
                   
                 Trofosfamide 
               
               
                   
                 Chlorambucil 
               
               
                 Nitrosoureas: 
                 Carmustine (BCNU) 
               
               
                   
                 Lomustine (CCNU) 
               
               
                 Alkylsulphonates: 
                 Busulfan 
               
               
                   
                 Treosulfan 
               
               
                 Triazenes: 
                 Dacarbazine 
               
               
                   
                 Procarbazine 
               
               
                   
                 Temozolomide 
               
               
                 Platinum containing complexes: 
                 Cisplatin 
               
               
                   
                 Carboplatin 
               
               
                   
                 Aroplatin 
               
               
                   
                 Oxaliplatin 
               
               
                 Plant Alkaloids 
                   
               
               
                 Vinca alkaloids: 
                 Vincristine 
               
               
                   
                 Vinblastine 
               
               
                   
                 Vindesine 
               
               
                   
                 Vinorelbine 
               
               
                 Taxoids: 
                 Paclitaxel 
               
               
                   
                 Docetaxel 
               
               
                 DNA Topoisomerase Inhibitors 
                   
               
               
                 Epipodophyllins: 
                 Etoposide 
               
               
                   
                 Teniposide 
               
               
                   
                 Topotecan 
               
               
                   
                 9-aminocamptothecin 
               
               
                   
                 Camptothecin 
               
               
                   
                 Crisnatol 
               
               
                 Mitomycins: 
                 Mitomycin C 
               
               
                   
                 Anti-metabolites 
               
               
                 Anti-folates: 
                   
               
               
                 DHFR inhibitors: 
                 Methotrexate 
               
               
                   
                 Trimetrexate 
               
               
                 IMP dehydrogenase Inhibitors: 
                 Mycophenolic acid 
               
               
                   
                 Tiazofurin 
               
               
                   
                 Ribavirin 
               
               
                   
                 EICAR 
               
               
                 Ribonuclotide reductase 
                 Hydroxyurea 
               
               
                 Inhibitors: 
                 Deferoxamine 
               
               
                 Pyrimidine Analogs: 
                   
               
               
                 Uracil Analogs: 
                 5-Fluorouracil 
               
               
                   
                 Fluoxuridine 
               
               
                   
                 Doxifluridine 
               
               
                   
                 Ralitrexed 
               
               
                 Cytosine Analogs: 
                 Cytarabine (ara C) 
               
               
                   
                 Cytosine arabinoside 
               
               
                   
                 Fludarabine 
               
               
                   
                 Gemcitabine 
               
               
                   
                 Capecitabine 
               
               
                 Purine Analogs: 
                 Mercaptopurine 
               
               
                   
                 Thioguanine 
               
               
                 DNA Antimetabolites: 
                 3-HP 
               
               
                   
                 2′-deoxy-5-fluorouridine 
               
               
                   
                 5-HP 
               
               
                   
                 alpha-TGDR 
               
               
                   
                 aphidicolin glycinate 
               
               
                   
                 ara-C 
               
               
                   
                 5-aza-2′-deoxycytidine 
               
               
                   
                 beta-TGDR 
               
               
                   
                 cyclocytidine 
               
               
                   
                 guanazole 
               
               
                   
                 inosine glycodialdehyde 
               
               
                   
                 macebecin II 
               
               
                   
                 Pyrazoloimidazole 
               
               
                 Hormonal therapies: 
                   
               
               
                 Receptor antagonists: 
                   
               
               
                 Anti-estrogen: 
                 Tamoxifen 
               
               
                   
                 Raloxifene 
               
               
                   
                 Megestrol 
               
               
                 LHRH agonists: 
                 Goscrclin 
               
               
                   
                 Leuprolide acetate 
               
               
                 Anti-androgens: 
                 Flutamide 
               
               
                   
                 Bicalutamide 
               
               
                 Retinoids/Deltoids 
                   
               
               
                 Vitamin A derivative: 
                 Cis-retinoic acid 
               
               
                   
                 All-trans retinoic acid (ATRA-IV) 
               
               
                 Vitamin D3 Analogs: 
                 EB 1089 
               
               
                   
                 CB 1093 
               
               
                   
                 KH 1060 
               
               
                 Photodynamic therapies: 
                 Vertoporfin (BPD-MA) 
               
               
                   
                 Phthalocyanine 
               
               
                   
                 Photosensitizer Pc4 
               
               
                   
                 Demethoxy-hypocrellin A 
               
               
                   
                 (2BA-2-DMHA) 
               
               
                 Cytokines: 
                 Interferon-α 
               
               
                   
                 Interferon-β 
               
               
                   
                 Interferon-γ 
               
               
                   
                 Tumor necrosis factor 
               
               
                   
                 Interleukin-2 
               
               
                 Angiogenesis Inhibitors: 
                 Angiostatin (plasminogen 
               
               
                   
                 fragment) 
               
               
                   
                 antiangiogenic antithrombin III 
               
               
                   
                 Angiozyme 
               
               
                   
                 ABT-627 
               
               
                   
                 Bay 12-9566 
               
               
                   
                 Benefin 
               
               
                   
                 Bevacizumab 
               
               
                   
                 BMS-275291 
               
               
                   
                 cartilage-derived inhibitor (CDI) 
               
               
                   
                 CAI 
               
               
                   
                 CD59 complement fragment 
               
               
                   
                 CEP-7055 
               
               
                   
                 Col 3 
               
               
                   
                 Combretastatin A-4 
               
               
                   
                 Endostatin (collagen XVIII 
               
               
                   
                 fragment) 
               
               
                   
                 Fibronectin fragment 
               
               
                   
                 Gro-beta 
               
               
                   
                 Halofuginone 
               
               
                   
                 Heparinases 
               
               
                   
                 Heparin hexasaccharide fragment 
               
               
                   
                 HMV833 
               
               
                   
                 Human chorionic gonadotropin 
               
               
                   
                 (hCG) 
               
               
                   
                 IM-862 
               
               
                   
                 Interferon alpha/beta/gamma 
               
               
                   
                 Interferon inducible protein (IP- 
               
               
                   
                 10) 
               
               
                   
                 Interleukin-12 
               
               
                   
                 Kringle 5 (plasminogen fragment) 
               
               
                   
                 Marimastat 
               
               
                   
                 Metalloproteinase inhibitors 
               
               
                   
                 (TIMPs) 
               
               
                   
                 2-Methoxyestradiol 
               
               
                   
                 MMI 270 (CGS 27023A) 
               
               
                   
                 MoAb IMC-1C11 
               
               
                   
                 Neovastat 
               
               
                   
                 NM-3 
               
               
                   
                 Panzem 
               
               
                   
                 PI-88 
               
               
                   
                 Placental ribonuclease inhibitor 
               
               
                   
                 Plasminogen activator inhibitor 
               
               
                   
                 Platelet factor-4 (PF4) 
               
               
                   
                 Prinomastat 
               
               
                   
                 Prolactin 16 kD fragment 
               
               
                   
                 Proliferin-related protein (PRP) 
               
               
                   
                 PTK 787/ZK 222594 
               
               
                   
                 Retinoids 
               
               
                   
                 Solimastat 
               
               
                   
                 Squalamine 
               
               
                   
                 SS 3304 
               
               
                   
                 SU 5416 
               
               
                   
                 SU6668 
               
               
                   
                 SU11248 
               
               
                   
                 Tetrahydrocortisol-S 
               
               
                   
                 Tetrathiomolybdate 
               
               
                   
                 Thalidomide 
               
               
                   
                 Thrombospondin-1 (TSP-1) 
               
               
                   
                 TNP-470 
               
               
                   
                 Transforming growth factor-beta 
               
               
                   
                 (TGF-β) 
               
               
                   
                 Vasculostatin 
               
               
                   
                 Vasostatin (calreticulin fragment) 
               
               
                   
                 ZD6126 
               
               
                   
                 ZD 6474 
               
               
                   
                 farnesyl transferase inhibitors 
               
               
                   
                 (FTI) 
               
               
                   
                 Bisphosphonates 
               
               
                 Antimitotic agents: 
                 Allocolchicine 
               
               
                   
                 Halichondrin B 
               
               
                   
                 Colchicine 
               
               
                   
                 colchicine derivative 
               
               
                   
                 dolstatin 10 
               
               
                   
                 Maytansine 
               
               
                   
                 Rhizoxin 
               
               
                   
                 Thiocolchicine 
               
               
                   
                 trityl cysteine 
               
               
                 Others: 
                   
               
               
                 Isoprenylation inhibitors: 
                   
               
               
                 Dopaminergic neurotoxins: 
                 1-methyl-4-phenylpyridinium ion 
               
               
                 Cell cycle inhibitors: 
                 Staurosporine 
               
               
                 Actinomycins: 
                 Actinomycin D 
               
               
                   
                 Dactinomycin 
               
               
                 Bleomycins: 
                 Bleomycin A2 
               
               
                   
                 Bleomycin B2 
               
               
                   
                 Peplomycin 
               
               
                 Anthracyclines: 
                 Daunorubicin 
               
               
                   
                 Doxorubicin (adriamycin) 
               
               
                   
                 Idarubicin 
               
               
                   
                 Epirubicin 
               
               
                   
                 Pirarubicin 
               
               
                   
                 Zorubicin 
               
               
                   
                 Mitoxantrone 
               
               
                 MDR inhibitors: 
                 Verapamil 
               
               
                 Ca 2+  ATPase inhibitors: 
                 Thapsigargin 
               
               
                   
               
            
           
         
       
     
     Other additional anticancer agents that are useful in the compositions and methods of the present invention include, but are not limited to: acivicin; aclarubicin; acodazole hydrochloride; acronine; adozelesin; aldesleukin; altretamine; ambomycin; ametantrone acetate; aminoglutethimide; amsacrine; anastrozole; anthramycin; asparaginase; asperlin; azacitidine; azetepa; azotomycin; batimastat; benzodepa; bicalutamide; bisantrene hydrochloride; bisnafide dimesylate; bizelesin; bleomycin sulfate; brequinar sodium; bropirimine; busulfan; cactinomycin; calusterone; caracemide; carbetimer; carboplatin; carmustine; carubicin hydrochloride; carzelesin; cedefingol; chlorambucil; cirolemycin; cisplatin; cladribine; crisnatol mesylate; cyclophosphamide; cytarabine; dacarbazine; dactinomycin; daunorubicin hydrochloride; decitabine; dexormaplatin; dezaguanine; dezaguanine mesylate; diaziquone; docetaxel; doxorubicin; doxorubicin hydrochloride; droloxifene; droloxifene citrate; dromostanolone propionate; duazomycin; edatrexate; eflornithine hydrochloride; elsamitrucin; enloplatin; enpromate; epipropidine; epirubicin hydrochloride; erbulozole; esorubicin hydrochloride; estramustine; estramustine phosphate sodium; etanidazole; etoposide; etoposide phosphate; etoprine; fadrozole hydrochloride; fazarabine; fenretinide; floxuridine; fludarabine phosphate; fluorouracil; fluorocitabine; fosquidone; fostriecin sodium; gemcitabine hydrochloride; hydroxyurea; idarubicin hydrochloride; ifosfamide; ilmofosine; interleukin-2 (including recombinant interleukin-2, or rIL2), interferon alfa-2a; interferon alfa-2β; interferon alfa-n1; interferon alfa-n3; interferon beta-Iα; interferon gamma-Iβ; iproplatin; irinotecan hydrochloride; lanreotide acetate; letrozole; leuprolide acetate; liarozole hydrochloride; lometrexol sodium; lomustine; losoxantrone hydrochloride; masoprocol; maytansine; mechlorethamine hydrochloride; megestrol acetate; melengestrol acetate; melphalan; menogaril; mercaptopurine; methotrexate; methotrexate sodium; metoprine; meturedepa; mitindomide; mitocarcin; mitocromin; mitogillin; mitomalcin; mitomycin; mitosper; mitotane; mitoxantrone hydrochloride; mycophenolic acid; nocodazole; nogalamycin; ormaplatin; oxisuran; paclitaxel; pegaspargase; peliomycin; pentamustine; peplomycin sulfate; perfosfamide; pipobroman; piposulfan; piroxantrone hydrochloride; plicamycin; plomestane; porfimer sodium; porfiromycin; prednimustine; procarbazine hydrochloride; puromycin; puromycin hydrochloride; pyrazofurin; riboprine; rogletimide; safingol; safingol hydrochloride; semustine; simtrazene; sparfosate sodium; sparsomycin; spirogermanium hydrochloride; spiromustine; spiroplatin; streptonigrin; streptozocin; sulofenur; talisomycin; tecogalan sodium; tegafur; teloxantrone hydrochloride; temoporfin; teniposide; teroxirone; testolactone; thiamiprine; thioguanine; thiotepa; tiazofurin; tirapazamine; toremifene citrate; trestolone acetate; triciribine phosphate; trimetrexate; trimetrexate glucuronate; triptorelin; tubulozole hydrochloride; uracil mustard; uredepa; vapreotide; verteporfin; vinblastine sulfate; vincristine sulfate; vindesine; vindesine sulfate; vinepidine sulfate; vinglycinate sulfate; vinleurosine sulfate; vinorelbine tartrate; vinrosidine sulfate; vinzolidine sulfate; vorozole; zeniplatin; zinostatin; zorubicin hydrochloride. 
     Further anticancer drugs that are useful in the methods and compositions of the invention include, but are not limited to: 20-epi-1,25 dihydroxyvitamin D3; 5-ethynyluracil; abiraterone; aclarubicin; acylfulvene; adecypenol; adozelesin; aldesleukin; ALL-TK antagonists; altretamine; ambamustine; amidox; amifostine; aminolevulinic acid; amrubicin; amsacrine; anagrelide; anastrozole; andrographolide; angiogenesis inhibitors; antagonist D; antagonist G; antarelix; anti-dorsalizing morphogenetic protein-1; antiandrogen, prostatic carcinoma; antiestrogen; antineoplaston; antisense oligonucleotides; aphidicolin glycinate; apoptosis gene modulators; apoptosis regulators; apurinic acid; ara-CDP-DL-PTBA; arginine deaminase; asulacrine; atamestane; atrimustine; axinastatin 1; axinastatin 2; axinastatin 3; azasetron; azatoxin; azatyrosine; baccatin III derivatives; balanol; batimastat; BCR/ABL antagonists; benzochlorins; benzoylstaurosporine; beta Lactam Derivatives; beta-alethine; betaclamycin B; betulinic acid; bFGF inhibitor; bicalutamide; bisantrene; bisaziridinylspermine; bisnafide; bistratene A; bizelesin; breflate; bropirimine; budotitane; buthionine sulfoximine; calcipotriol; calphostin C; camptothecin derivatives; canarypox IL-2; carboxamide-amino-triazole; carboxyamidotriazole; CaRest M3; CARN 700; cartilage derived inhibitor; carzelesin; casein kinase inhibitors (ICOS); castanospermine; cecropin B; cetrorelix; chlorlns; chloroquinoxaline sulfonamide; cicaprost; cis-porphyrin; cladribine; clomifene Analogues; clotrimazole; collismycin A; collismycin B; combretastatin A4; combretastatin Analogue; conagenin; crambescidin 816; crisnatol; cryptophycin 8; cryptophycin A derivatives; curacin A; cyclopentanthraquinones; cycloplatam; cypemycin; cytarabine ocfosfate; cytolytic factor; cytostatin; dacliximab; decitabine; dehydrodidemnin B; deslorelin; dexamethasone; dexifosfamide; dexrazoxane; dexverapamil; diaziquone; didemnin B; didox; diethylnorspermine; dihydro-5-acytidine; dihydrotaxol; dioxamycin; diphenyl spiromustine; docetaxel; docosanol; dolasetron; doxifluridine; droloxifene; dronabinol; duocarmycin SA; ebselen; ecomustine; edelfosine; edrecolomab; eflornithine; elemene; emitefur; epirubicin; epristeride; estramustine Analogue; estrogen agonists; estrogen antagonists; etanidazole; etoposide phosphate; exemestane; fadrozole; fazarabine; fenretinide; filgrastim; finasteride; flavopiridol; flezelastine; fluasterone; fludarabine; fluorodaunorunicin hydrochloride; forfenimex; formestane; fostriecin; fotemustine; gadolinium texaphyrin; gallium nitrate; galocitabine; ganirelix; gelatinase inhibitors; gemcitabine; glutathione inhibitors; hepsulfam; heregulin; hexamethylene bisacetamide; hypericin; ibandronic acid; idarubicin; idoxifene; idramantone; ilmofosine; ilomastat; imidazoacridones; imiquimod; immunostimulant peptides; insulin-like growth factor-1 receptor inhibitor; interferon agonists; interferons; interleukins; iobenguane; iododoxorubicin; ipomeanol, 4-; iroplact; irsogladine; isobengazole; isohomohalicondrin B; itasetron; jasplakinolide; kahalalide F; lamellarin-N triacetate; lanreotide; leinamycin; lenograstim; lentinan sulfate; leptolstatin; letrozole; leukemia inhibiting factor; leukocyte alpha interferon; leuprolide+estrogen+progesterone; leuprorelin; levamisole; liarozole; linear polyamine Analogue; lipophilic disaccharide peptide; lipophilic platinum complexes; lissoclinamide 7; lobaplatin; lombricine; lometrexol; lonidamine; losoxantrone; lovastatin; loxoribine; lurtotecan; lutetium texaphyrin; lysofylline; lytic peptides; maitansine; mannostatin A; marimastat; masoprocol; maspin; matrilysin inhibitors; matrix metalloproteinase inhibitors; menogaril; merbarone; meterelin; methioninase; metoclopramide; MIF inhibitor; mifepristone; miltefosine; mirimostim; mismatched double stranded RNA; mitoguazone; mitolactol; mitomycin Analogues; mitonafide; mitotoxin fibroblast growth factor-saporin; mitoxantrone; mofarotene; molgramostim; monoclonal antibody, human chorionic gonadotrophin; monophosphoryl lipid A+myobacterium cell wall sk; mopidamol; multiple drug resistance gene inhibitor; multiple tumor suppressor 1-based therapy; mustard anticancer agents; mycaperoxide B; mycobacterial cell wall extract; myriaporone; N-acetyldinaline; N-substituted benzamides; nafarelin; nagrestip; naloxone+pentazocine; napavin; naphterpin; nartograstim; nedaplatin; nemorubicin; neridronic acid; neutral endopeptidase; nilutamide; nisamycin; nitric oxide modulators; nitroxide antioxidant; nitrullyn; 06-benzylguanine; octreotide; okicenone; oligonucleotides; onapristone; ondansetron; ondansetron; oracin; oral cytokine inducer; ormaplatin; osaterone; oxaliplatin; oxaunomycin; paclitaxel; paclitaxel Analogues; paclitaxel derivatives; palauamine; palmitoylrhizoxin; pamidronic acid; panaxytriol; panomifene; parabactin; pazelliptine; pegaspargase; peldesine; pentosan polysulfate sodium; pentostatin; pentrozole; perflubron; perfosfamide; perillyl alcohol; phenazinomycin; phenylacetate; phosphatase inhibitors; picibanil; pilocarpine hydrochloride; pirarubicin; piritrexim; placetin A; placetin B; plasminogen activator inhibitor; platinum complex; platinum complexes; platinum-triamine complex; porfimer sodium; porfiromycin; prednisone; propyl bis-acridone; prostaglandin J2; proteasome inhibitors; protein A-based immune modulator; protein kinase C inhibitor; protein kinase C inhibitors, microalgal; protein tyrosine phosphatase inhibitors; purine nucleoside phosphorylase inhibitors; purpurins; pyrazoloacridine; pyridoxylated hemoglobin polyoxyethylene conjugate; raf antagonists; raltitrexed; ramosetron; ras farnesyl protein transferase inhibitors; ras inhibitors; ras-GAP inhibitor; retelliptine demethylated; rhenium Re 186 etidronate; rhizoxin; ribozymes; RII retinamide; rogletimide; rohitukine; romurtide; roquinimex; rubiginone B1; ruboxyl; safingol; saintopin; SarCNU; sarcophytol A; sargramostim; Sdi 1 mimetics; semustine; senescence derived inhibitor 1; sense oligonucleotides; signal transduction inhibitors; signal transduction modulators; single chain antigen binding protein; sizofuran; sobuzoxane; sodium borocaptate; sodium phenylacetate; solverol; somatomedin binding protein; sonermin; sparfosic acid; spicamycin D; spiromustine; splenopentin; spongistatin 1; squalamine; stem cell inhibitor; stem-cell division inhibitors; stipiamide; stromelysin inhibitors; sulfinosine; superactive vasoactive intestinal peptide antagonist; suradista; suramin; swainsonine; synthetic glycosaminoglycans; tallimustine; tamoxifen methiodide; tauromustine; tazarotene; tecogalan sodium; tegafur; tellurapyrylium; telomerase inhibitors; temoporfin; temozolomide; teniposide; tetrachlorodecaoxide; tetrazomine; thaliblastine; thiocoraline; thrombopoietin; thrombopoietin mimetic; thymalfasin; thymopoietin receptor agonist; thymotrinan; thyroid stimulating hormone; tin ethyl etiopurpurin; tirapazamine; titanocene bichloride; topsentin; toremifene; totipotent stem cell factor; translation inhibitors; tretinoin; triacetyluridine; triciribine; trimetrexate; triptorelin; tropisetron; turosteride; tyrosine kinase inhibitors; tyrphostins; UBC inhibitors; ubenimex; urogenital sinus-derived growth inhibitory factor; urokinase receptor antagonists; vapreotide; variolin B; vector system, erythrocyte gene therapy; velaresol; veramine; verdins; verteporfin; vinorelbine; vinxaltine; vitaxin; vorozole; zanoterone; zeniplatin; zilascorb; and zinostatin stimalamer. 
     In one another embodiment, the other anticancer agent is interferon-α. 
     In another embodiment, the other anticancer agent is interleukin-2. 
     In one embodiment, the other anticancer agent is an alkylating agent, such as a nitrogen mustard, a nitrosourea, an alkylsulfonate, a triazene, or a platinum-containing agent. 
     In one embodiment, the other anticancer agent is a triazene alkylating agent. 
     In another embodiment, the other anticancer agent is temozolomide, procarbazine, dacarbazine, interleukin-2, irinotecan, doxorubicin, or a combination thereof. 
     In a specific embodiment, the other anticancer agent is temozolomide. 
     Temozolomide can be administered to a subject at dosages ranging from about 60 mg/m 2  (of a subject&#39;s body surface area) to about 250 mg/m 2  and from about 100 mg/m 2  to about 200 mg/m 2 . In specific embodiments, the dosages of temozolomide are about 10 mg/m 2 , about 1 mg/m 2 , about 5 mg/m 2 , about 10 mg/m 2 , about 20 mg/m 2 , about 30 mg/m 2 , about 40 mg/m 2 , about 50 mg/m 2 , about 60 mg/m 2 , about 70 mg/m 2 , about 80 mg/m 2 , about 90 mg/m 2 , about 100 mg/m 2 , about 110 mg/m 2 , about 120 mg/m 2 , about 130 mg/m 2 , about 140 mg/m 2 , about 150 mg/m 2 , about 160 mg/m 2 , about 170 mg/m 2 , about 180 mg/m 2 , about 190 mg/m 2 , about 200 mg/m 2 , about 210 mg/m 2 , about 220 mg/m 2 , about 230 mg/m 2 , about 240 mg/m 2 , or about 250 mg/m 2 . 
     In a specific embodiment, temozolomide is administered orally. 
     In one embodiment, temozolomide is administered orally to a subject at a dose ranging from about 150 mg/m 2  to about 200 mg/m 2 . 
     In another embodiment, temozolomide is administered orally to a subject once per day for five consecutive days at a dose ranging from about 150 mg/m 2  to about 200 mg/m 2 . 
     In a specific embodiment, temozolomide is administered orally to a subject once per day for five consecutive days at a dose ranging from about 150 mg/m 2  to about 200 mg/m 2  on days 1-5, then again orally once per day for five consecutive days on days 28-32 at a dose ranging from about 150 mg/m 2  to about 200 mg/m 2 , then again orally once per day for five consecutive days on days 55-59 at a dose ranging from about 150 mg/m 2  to about 200 mg/m 2 . 
     In another embodiment, temozolomide is administered orally to a subject once per day for a week, two weeks, three weeks, a month or longer at the foregoing daily dosage. 
     In a specific embodiment, the other anticancer agent is procarbazine. 
     Procarbazine can be administered to a subject at dosages ranging from about 50 mg/m 2  (of a subject&#39;s body surface area) to about 100 mg/m 2  and from about 60 mg/m 2  to about 100 mg/m 2 . In specific embodiments, the dosages of procarbazine are about 10 mg/m 2 , about 1 mg/m 2 , about 5 mg/m 2 , about 10 mg/m 2 , about 20 mg/m 2 , about 30 mg/m 2 , about 40 mg/m 2 , about 50 mg/m 2 , about 60 mg/m 2 , about 70 mg/m 2 , about 80 mg/m 2 , about 90 mg/m 2 , about 100 mg/m 2 , about 110 mg/m 2 , about 120 mg/m 2 , about 130 mg/m 2 , about 140 mg/m 2 , about 150 mg/m 2 , about 160 mg/m 2 , about 170 mg/m 2 , about 180 mg/m 2 , about 190 mg/m 2 , about 200 mg/m 2 , about 210 mg/m 2 , about 220 mg/m 2 , about 230 mg/m 2 , about 240 mg/m 2 , about 250 mg/m 2 , about 260 mg/m 2 , about 270 mg/m 2 , about 280 mg/m 2 , about 290 mg/m 2 , about 300 mg/m 2 , about 310 mg/m 2 , about 320 mg/m 2 , about 330 mg/m 2 , about 340 mg/m 2 , about 350 mg/m 2 , about 360 mg/m 2 , about 370 mg/m 2 , about 380 mg/m 2 , about 390 mg/m 2 , about 400 mg/m 2 , about 410 mg/m 2 , about 420 mg/m 2 , about 430 mg/m 2 , about 440 mg/m 2 , about 450 mg/m 2 , about 460 mg/m 2 , about 470 mg/m 2 , about 480 mg/m 2 , about 490 mg/m 2 , or about 500 mg/m 2 . 
     In a specific embodiment, procarbazine is administered intravenously. 
     In one embodiment, procarbazine is administered intravenously to a subject at a dose ranging from about 50 mg/m 2  to about 100 mg/m 2 . 
     In another embodiment, procarbazine is administered intravenously to a subject once per day for five consecutive days at a dose ranging from about 50 mg/m 2  to about 100 mg/m 2 . 
     In a specific embodiment, procarbazine is administered intravenously to a subject once per day for five consecutive days at a dose ranging from about 50 mg/m 2  to about 100 mg/m 2  on days 1-5, then again intravenously once per day for five consecutive days on days 28-32 at a dose ranging from about 50 mg/m 2  to about 100 mg/m 2 , then again intravenously once per day for five consecutive days on days 55-59 at a dose ranging from about 50 mg/m to about 100 mg/m 2 . 
     In another embodiment, procarbazine is administered once intravenously to a subject at a dose ranging from about 50 mg/m 2  to about 100 mg/m 2 . 
     In another embodiment, procarbazine is administered intravenously to a subject once per day for a week, two weeks, three weeks, a month or longer at the foregoing daily dosage. 
     In a specific embodiment, the other anticancer agent is dacarbazine. 
     Dacarbazine can be administered to a subject at dosages ranging from about 60 mg/m 2  (of a subject&#39;s body surface area) to about 250 mg/m 2  and from about 150 mg/m 2  to about 250 mg/m 2 . In specific embodiments, the dosages of dacarbazine are about 10 mg/m, about 1 mg/m 2 , about 5 mg/m 2 , about 10 mg/m 2 , about 20 mg/m 2 , about 30 mg/m 2 , about 40 mg/m 2 , about 50 mg/m 2 , about 60 mg/m 2 , about 70 mg/m 2 , about 80 mg/m 2 , about 90 mg/m 2 , about 100 mg/m 2 , about 110 mg/m 2 , about 120 mg/m 2 , about 130 mg/m 2 , about 140 mg/m 2 , about 150 mg/m 2 , about 160 mg/m 2 , about 170 mg/m 2 , about 180 mg/m 2 , about 190 mg/m 2 , about 200 mg/m 2 , about 210 mg/m 2 , about 220 mg/m 2 , about 230 mg/m 2 , about 240 mg/m 2 , about 250 mg/m 2 , about 260 mg/m 2 , about 270 mg/m 2 , about 280 mg/m 2 , about 290 mg/m 2 , about 300 mg/m 2 , about 310 mg/m 2 , about 320 mg/m 2 , about 330 mg/m 2 , about 340 mg/m 2 , about 350 mg/m 2 , about 360 mg/m 2 , about 370 mg/m 2 , about 380 mg/m 2 , about 390 mg/m 2 , about 400 mg/m 2 , about 410 mg/m 2 , about 420 mg/m 2 , about 430 mg/m 2 , about 440 mg/m 2 , about 450 mg/m 2 , about 460 mg/m 2 , about 470 mg/m 2 , about 480 mg/m 2 , about 490 mg/m 2 , or about 500 mg/m 2 . 
     In a specific embodiment, dacarbazine is administered intravenously. 
     In one embodiment, dacarbazine is administered intravenously to a subject at a dose ranging from about 150 mg/m 2  to about 250 mg/m 2 . 
     In another embodiment, dacarbazine is administered intravenously to a subject once per day for five consecutive days at a dose ranging from about 150 mg/m 2  to about 250 mg/m 2 . 
     In a specific embodiment, dacarbazine is administered intravenously to a subject once per day for five consecutive days at a dose ranging from about 150 mg/m 2  to about 250 mg/m 2  on days 1-5, then again intravenously once per day for five consecutive days on days 28-32 at a dose ranging from about 150 mg/m 2  to about 250 mg/m 2 , then again intravenously once per day for five consecutive days on days 55-59 at a dose ranging from about 150 mg/m 2  to about 250 mg/m 2 . 
     In one embodiment, dacarbazine is administered once intravenously to a subject at a dose ranging from about 150 mg/m 2  to about 250 mg/m 2 . 
     In another embodiment, dacarbazine is administered intravenously to a subject once per day for a week, two weeks, three weeks, a month or longer at the foregoing daily dosage. 
     In a specific embodiment, the other anticancer agent is doxorubicin. 
     Doxorubicin can be administered to a subject at dosages ranging from about 50 mg/m 2  (of a subject&#39;s body surface area) to about 100 mg/m 2  and from about 60 mg/m 2  to about 100 mg/m 2 . In specific embodiments, the dosages of doxorubicin are about 10 mg/m 2 , about 1 mg/m 2 , about 5 mg/m 2 , about 10 mg/m 2 , about 20 mg/m 2 , about 30 mg/m 2 , about 40 mg/m 2 , about 50 mg/m 2 , about 60 mg/m 2 , about 70 mg/m 2 , about 80 mg/m 2 , about 90 mg/m 2 , about 100 mg/m 2 , about 110 mg/m 2 , about 120 mg/m 2 , about 130 mg/m 2 , about 140 mg/m 2 , about 150 mg/m 2 , about 160 mg/m 2 , about 170 mg/m 2 , about 180 mg/m 2 , about 190 mg/m 2 , about 200 mg/m 2 , about 210 mg/m 2 , about 220 mg/m 2 , about 230 mg/m 2 , about 240 mg/m 2 , about 250 mg/m 2 , about 260 mg/m 2 , about 270 mg/m 2 , about 280 mg/m 2 , about 290 mg/m 2 , about 300 mg/m 2 , about 310 mg/m 2 , about 320 mg/m 2 , about 330 mg/m 2 , about 340 mg/m 2 , about 350 mg/m 2 , about 360 mg/m 2 , about 370 mg/m 2 , about 380 mg/m 2 , about 390 mg/m 2 , about 400 mg/m 2 , about 410 mg/m 2 , about 420 mg/m 2 , about 430 mg/m 2 , about 440 mg/m 2 , about 450 mg/m 2 , about 460 mg/m 2 , about 470 mg/m 2 , about 480 mg/m 2 , about 490 mg/m 2 , or about 500 mg/m 2 . 
     In a specific embodiment, doxorubicin is administered intravenously. 
     In one embodiment, doxorubicin is administered intravenously to a subject at a dose ranging from about 50 mg/m 2  to about 100 mg/m 2 . 
     In another embodiment, doxorubicin is administered intravenously to a subject once per day for five consecutive days at a dose ranging from about 50 mg/m 2  to about 100 mg/m 2 . 
     In a specific embodiment, doxorubicin is administered intravenously to a subject once per day for five consecutive days at a dose ranging from about 50 mg/m 2  to about 100 mg/m 2  on days 1-5, then again intravenously once per day for five consecutive days on days 28-32 at a dose ranging from about 50 mg/m 2  to about 100 mg/m 2 , then again intravenously once per day for five consecutive days on days 55-59 at a dose ranging from about 50 mg/m 2  to about 100 mg/m 2 . 
     In another embodiment, doxorubicin is administered once intravenously to a subject at a dose ranging from about 50 mg/m 2  to about 100 mg/m 2 . 
     In another embodiment, doxorubicin is administered intravenously to a subject once per day for a week, two weeks, three weeks, a month or longer at the foregoing daily dosage. 
     In one embodiment, the other anticancer agent is a Topoisomerase I inhibitor, such as etoposide, teniposide, topotecan, irinotecan, 9-aminocamptothecin, camptothecin, or crisnatol. 
     In a specific embodiment, the other anticancer agent is irinotecan. 
     Irinotecan can be administered to a subject at dosages ranging from about 50 mg/m 2  (of a subject&#39;s body surface area) to about 150 mg/m 2  and from about 75 mg/m 2  to about 150 mg/m 2 . In specific embodiments, the dosages of irinotecan are about 10 mg/m 2 , about 1 mg/m 2 , about 5 mg/m 2 , about 10 mg/m 2 , about 20 mg/m 2 , about 30 mg/m 2 , about 40 mg/m 2 , about 50 mg/m 2 , about 60 mg/m 2 , about 70 mg/m 2 , about 80 mg/m 2 , about 90 mg/m 2 , about 100 mg/m 2 , about 110 mg/m 2 , about 120 mg/m 2 , about 130 mg/m 2 , about 140 mg/m 2 , about 150 mg/m 2 , about 160 mg/m 2 , about 170 mg/m 2 , about 180 mg/m 2 , about 190 mg/m 2 , about 200 mg/m 2 , about 210 mg/m 2 , about 220 mg/m 2 , about 230 mg/m 2 , about 240 mg/m 2 , about 250 mg/m 2 , about 260 mg/m 2 , about 270 mg/m 2 , about 280 mg/m 2 , about 290 mg/m 2 , about 300 mg/m 2 , about 310 mg/m 2 , about 320 mg/m 2 , about 330 mg/m 2 , about 340 mg/m 2 , about 350 mg/m 2 , about 360 mg/m 2 , about 370 mg/m 2 , about 380 mg/m 2 , about 390 mg/m 2 , about 400 mg/m 2 , about 410 mg/m 2 , about 420 mg/m 2 , about 430 mg/m 2 , about 440 mg/m 2 , about 450 mg/m 2 , about 460 mg/m 2 , about 470 mg/m 2 , about 480 mg/m 2 , about 490 mg/m 2 , or about 500 mg/m 2 . 
     In a specific embodiment, irinotecan is administered intravenously. 
     In one embodiment, irinotecan is administered intravenously to a subject at a dose ranging from about 50 mg/m 2  to about 150 mg/m 2 . 
     In another embodiment, irinotecan is administered intravenously to a subject once per day for five consecutive days at a dose ranging from about 50 mg/m 2  to about 150 mg/m 2 . 
     In a specific embodiment, irinotecan is administered intravenously to a subject once per day for five consecutive days at a dose ranging from about 50 mg/m 2  to about 150 mg/m 2  on days 1-5, then again intravenously once per day for five consecutive days on days 28-32 at a dose ranging from about 50 mg/m 2  to about 150 mg/m 2 , then again intravenously once per day for five consecutive days on days 55-59 at a dose ranging from about 50 mg/m 2  to about 150 mg/m 2 . 
     In another embodiment, irinotecan is administered intravenously to a subject once per day for a week, two weeks, three weeks, a month or longer at the foregoing daily dosage. 
     In one embodiment, the other anticancer agent is O-6-benzylguanine. 
     In another embodiment, the other anticancer agent is O-6-benzylguanine and temozolomide. 
     In another embodiment, the other anticancer agent is O-6-benzylguanine and procarbazine. 
     In still another embodiment, the other anticancer agent is O-6-benzylguanine and dacarbazine. 
     5.8.10.3 Multi-Therapy for Cancer 
     The Indenoisoquinolinone Analogs can be administered to a subject that has undergone or is currently undergoing one or more additional anticancer therapies including, but not limited to, surgery, radiation therapy, or immunotherapy, such as cancer vaccines. 
     In one embodiment, the invention provides methods for treating or preventing cancer comprising administering to a subject in need thereof an effective amount of an Indenoisoquinolinone Analog to treat or prevent cancer and another anticancer therapy including, but not limited to, surgery, radiation therapy, or immunotherapy, such as a cancer vaccine. 
     In one embodiment, the other anticancer therapy is radiation therapy. 
     In another embodiment, the other anticancer therapy is surgery. 
     In still another embodiment, the other anticancer therapy is immunotherapy. 
     In a specific embodiment, the present methods for treating or preventing cancer comprise administering an effective amount of an Indenoisoquinolinone Analog and radiation therapy. The radiation therapy can be administered concurrently with, prior to, or subsequent to the Indenoisoquinolinone Analog, in one embodiment at least an hour, five hours, 12 hours, a day, a week, a month, in another embodiment several months (e.g., up to three months), prior or subsequent to administration of the Indenoisoquinolinone Analog. 
     Where the other anticancer therapy is radiation therapy, any radiation therapy protocol can be administered depending upon the type of cancer to be treated. For example, but not by way of limitation, X-ray radiation can be administered; specifically, high-energy megavoltage (radiation of greater that 1 MeV energy) can be administered for deep tumors, and electron beam and orthovoltage X-ray radiation can be administered for skin cancers. Gamma-ray emitting radioisotopes, such as radioactive isotopes of radium, cobalt and other elements, can also be administered. 
     Additionally, the invention provides methods of treatment of cancer comprising administering an Indenoisoquinolinone Analog as an alternative to chemotherapy or radiation therapy where the chemotherapy or the radiation therapy results in a negative side effect in the subject being treated. The subject being treated can, optionally, be treated with another anticancer therapy such as surgery, radiation therapy, or immunotherapy. 
     The Indenoisoquinolinone Analogs can also be administered in vitro or ex vivo, such as for the treatment of certain cancers, including, but not limited to leukemias and lymphomas, such treatment involving autologous stem cell transplants. This can involve a process in which the subject&#39;s autologous hematopoietic stem cells are harvested and purged of all cancer cells, the subject&#39;s remaining bone-marrow cell population is then eradicated via the administration of an Indenoisoquinolinone Analog and/or radiation, and the resultant stem cells are infused back into the subject. Supportive care can be subsequently provided while bone marrow function is restored and the subject recovers. 
     5.8.11 Treatment or Prevention of Erectile Dysfunction 
     The Indenoisoquinolinone Analogs are useful for treating or preventing erectile dysfunction. Erectile dysfunction includes an inability to achieve or maintain a full erection, specifically that which is sufficient to achieve or maintain sexual intercourse. The inability can be a total inability, an inconsistent ability, or a tendency to maintain only a brief erection. Erectile dysfunction includes idiopathic erectile dysfunction, as well as that which can result, for example, from trauma, including mechanical trauma, specifically that resulting from surgery, to the nerves (such as during prostatectomy); diabetes mellitus; a cardiovascular disease, including atherosclerosis; radiation; or certain drugs. The erectile dysfunction can also be age-related. 
     In one embodiment, the erectile dysfunction results from prostate surgery. 
     In a further embodiment, the erectile dysfunction results from prostate nerve injury. 
     5.8.12 Treatment or Prevention of Urinary Incontinence 
     The Indenoisoquinolinone Analogs are also useful for treating or preventing urinary incontinence. Urinary incontinence can result, for example, from trauma, including mechanical trauma, specifically during childbirth or that resulting from surgery, to the nerves (such as during prostatectomy or gynecological surgery); diabetes mellitus; a cardiovascular disease, including atherosclerosis; radiation; or certain drugs. The urinary incontinence can also be age-related. 
     In one embodiment, the subject in need of urinary incontinence treatment or prevention is male. 
     In one embodiment, the subject in need of urinary incontinence treatment or prevention is female. 
     5.8.13 Treatment or Prevention of a Complication of Prematurity 
     The Indenoisoquinolinone Analogs are also useful for treating or preventing a complication of prematurity. Examples of complications of prematurity include, but are not limited to, retinopathy, hyaline-membrane disease and necrotizing enterocolitis. 
     5.8.14 Treatment or Prevention of Cardiomyopathy 
     The Indenoisoquinolinone Analogs are also useful for treating or preventing cardiomyopathy. 
     5.8.15 Treatment or Prevention of Retinopathy 
     The Indenoisoquinolinone Analogs are also useful for treating or preventing retinopathy. 
     5.8.16 Treatment or Prevention of Nephropathy 
     The Indenoisoquinolinone Analogs are also useful for treating or preventing nephropathy. 
     5.8.17 Treatment or Prevention of Neuropathy 
     The Indenoisoquinolinone Analogs are also useful for treating or preventing neuropathy. 
     5.9 Therapeutic/Prophylactic Administration and Compositions of the Invention 
     Due to their activity, the Indenoisoquinolinone Analogs are advantageously useful in veterinary and human medicine. As described above, the Indenoisoquinolinone Analogs are useful for treating or preventing a Condition in a subject in need thereof. 
     The Indenoisoquinolinone Analogs can be administered in amounts that are effective to treat or prevent a Condition in a subject in need thereof. 
     When administered to a subject, the Indenoisoquinolinone Analogs can be administered as a component of a composition that comprises a physiologically acceptable carrier or vehicle. The present compositions, which comprise an Indenoisoquinolinone Analog, can be administered orally. The Indenoisoquinolinone Analogs can also be administered by any other convenient route, for example, by infusion or bolus injection, by absorption through epithelial or mucocutaneous linings (e.g., oral, rectal, or intestinal mucosa) and can be administered together with another biologically active agent. Administration can be systemic or local. Various delivery systems are known, e.g., encapsulation in liposomes, microparticles, microcapsules and capsules. 
     Methods of administration include, but are not limited to, intradermal, intramuscular, intraperitoneal, intravenous, subcutaneous, intranasal, epidural, oral, sublingual, intracerebral, intravaginal, transdermal, rectal, by inhalation, or topical, specifically to the ears, nose, eyes, or skin. In some instances, administration will result in the release of an Indenoisoquinolinone Analog into the bloodstream. 
     In one embodiment, the Indenoisoquinolinone Analogs are administered orally. 
     In other embodiments, it can be desirable to administer the Indenoisoquinolinone Analogs locally. This can be achieved, for example, and not by way of limitation, by local infusion during surgery, topical application, e.g., in conjunction with a wound dressing after surgery, by injection, by means of a catheter, by means of a suppository or enema, or by means of an implant, said implant being of a porous, non-porous, or gelatinous material, including membranes, such as sialastic membranes, or fibers. 
     In certain embodiments, it can be desirable to introduce the Indenoisoquinolinone Analogs into the central nervous system or gastrointestinal tract by any suitable route, including intraventricular, intrathecal, and epidural injection, and enema. Intraventricular injection can be facilitated by an intraventricular catheter, for example, attached to a reservoir, such as an Ommaya reservoir. 
     Pulmonary administration can also be employed, e.g., by use of an inhaler of nebulizer, and formulation with an aerosolizing agent, or via perfusion in a fluorocarbon oar, synthetic pulmonary surfactant. In certain embodiments, the Indenoisoquinolinone Analogs can be formulated as a suppository, with traditional binders and excipients such as triglycerides. 
     In another embodiment Indenoisoquinolinone Analogs can be delivered in a vesicle, specifically a liposome (see Langer,  Science  249:1527-1533 (1990) and Treat or prevent et al.,  Liposomes in Therapy of Infectious Disease and Cancer  317-327 and 353-365 (1989)). 
     In yet another embodiment, the Indenoisoquinolinone Analogs can be delivered in a controlled-release system or sustained-release system (see, e.g., Goodson, in Medical Applications of Controlled Release, supra, vol. 2, pp. 115-138 (1984)). Other controlled or sustained-release systems discussed in the review by Langer,  Science  249:1527-1533 (1990) can be used. In one embodiment a pump can be used (Langer,  Science  249:1527-1533 (1990); Sefton,  CRC Crit. Ref. Biomed. Eng.  14:201 (1987); Buchwald et al.,  Surgery  88:507 (1980); and Saudek et al.,  N. Engl. J. Med.  321:574 (1989)). In another embodiment polymeric materials can be used (see  Medical Applications of Controlled Release  (Langer and Wise eds., 1974);  Controlled Drug Bioavailability, Drug Product Design and Performance  (Smolen and Ball eds., 1984); Ranger and Peppas,  J. Macromol. Sci. Rev. Macromol. Chem.  2:61 (1983); Levy et al.,  Science  228:190 (1935); During et al.,  Ann. Neural.  25:351 (1989); and Howard et al.,  J. Neurosurg.  71:105 (1989)). 
     In yet another embodiment a controlled- or sustained-release system can be placed in proximity of a target of the Indenoisoquinolinone Analogs, e.g., the spinal column, brain, skin, lung, or gastrointestinal tract, thus requiring only a fraction of the systemic dose. 
     The present compositions can optionally comprise a suitable amount of a pharmaceutically acceptable excipient so as to provide the form for proper administration to the subject. 
     Such pharmaceutical excipients can be liquids, such as water and oils, including those of petroleum, animal, vegetable, or synthetic origin, such as peanut oil, soybean oil, mineral oil, sesame oil and the like. The pharmaceutical excipients can be saline, gum acacia, gelatin, starch paste, talc, keratin, colloidal silica, urea and the like. In addition, auxiliary, stabilizing, thickening, lubricating, and coloring agents can be used. In one embodiment, the pharmaceutically acceptable excipients are sterile when administered to a subject. Water is a useful excipient when the Indenoisoquinolinone Analog is administered intravenously. Saline solutions and aqueous dextrose and glycerol solutions can also be employed as liquid excipients, specifically for injectable solutions. Suitable pharmaceutical excipients also include starch, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, sodium stearate, glycerol monostearate, talc, sodium chloride, dried skim milk, glycerol, propylene, glycol, water, ethanol and the like. The present compositions, if desired, can also contain minor amounts of wetting or emulsifying agents, or pH buffering agents. 
     The present compositions can take the form of solutions, suspensions, emulsion, tablets, pills, pellets, capsules, capsules containing liquids, powders, sustained-release formulations, suppositories, emulsions. aerosols, sprays, suspensions, or any other form suitable for use. In one embodiment, the composition is in the form of a capsule (see e.g. U.S. Pat. No. 5,698,155). Other examples of suitable pharmaceutical excipients are described in  Remington&#39;s Pharmaceutical Sciences  1447-1676 (Alfonso R. Gennaro eds., 19th ed. 1995), incorporated herein by reference. 
     In one embodiment, the Indenoisoquinolinone Analog is formulated in accordance with routine procedures as a composition adapted for oral administration to human beings. Compositions for oral delivery can be in the form of tablets, lozenges, aqueous or oily suspensions, granules, powders, emulsions, capsules, syrups, or elixirs for example. Orally administered compositions can contain one or more agents, for example, sweetening agents such as fructose, aspartame or saccharin; flavoring agents such as peppermint, oil of wintergreen, or cherry; coloring agents; and preserving agents, to provide a pharmaceutically palatable preparation. Moreover, where in tablet or pill form, the compositions can be coated to delay disintegration and absorption in the gastrointestinal tract thereby providing a sustained action over an extended period of time. Selectively permeable membranes surrounding an osmotically active driving an Indenoisoquinolinone Analog are also suitable for orally administered compositions. In these latter platforms, fluid from the environment surrounding the capsule is imbibed by the driving compound, which swells to displace the agent or agent composition through an aperture. These delivery platforms can provide an essentially zero order delivery profile as opposed to the spiked profiles of immediate release formulations. A time-delay material such as glycerol monostearate or glycerol stearate can also be useful. Oral compositions can include standard excipients such as mannitol, lactose, starch, magnesium stearate, sodium saccharin, cellulose, and magnesium carbonate. In one embodiment, the excipients are of pharmaceutical grade. 
     In another embodiment, the Indenoisoquinolinone Analogs can be formulated for intravenous administration. Typically, compositions for intravenous administration comprise sterile isotonic aqueous buffer. Where necessary, the compositions can also include a solubilizing agent. Compositions for intravenous administration can optionally include a local anesthetic such as lignocaine to lessen pain at the site of the injection. Generally, the ingredients are supplied either separately or mixed together in unit dosage form, for example, as a dry lyophilized-powder or water-free concentrate in a hermetically sealed container such as an ampule or sachette indicating the quantity of active agent. Where the Indenoisoquinolinone Analogs are to be administered by infusion, they can be dispensed, for example, with an infusion bottle containing sterile pharmaceutical grade water or saline. Where the Indenoisoquinolinone Analogs are administered by injection, an ampule of sterile water for injection or saline can be provided so that the ingredients can be mixed prior to administration. 
     Indenoisoquinolinone Analogs can be administered by controlled-release or sustained-release means or by delivery devices that are well known to those of ordinary skill in the art. Examples include, but are not limited to, those described in U.S. Pat. Nos. 3,845,770; 3,916,899; 3,536,809; 3,598,123; 4,008,719; 5,674,533; 5,059,595; 5,591,767; 5,120,548; 5,073,543; 5,639,476; 5,354,556; and 5,733,556, each of which is incorporated herein by reference in its entirety. Such dosage forms can be useful for providing controlled- or sustained-release of one or more active ingredients using, for example, hydropropylmethyl cellulose, other polymer matrices, gels, permeable membranes, osmotic systems, multilayer coatings, microparticles, liposomes, microspheres, or a combination thereof to provide the desired release profile in varying proportions. Suitable controlled- or sustained-release formulations known to those skilled in the art, including those described herein, can be readily selected for use with the active ingredients of the invention. The invention thus encompasses single unit dosage forms suitable for oral administration such as, but not limited to, tablets, capsules, gelcaps, and caplets that are adapted for controlled- or sustained-release. 
     In one embodiment a controlled- or sustained-release composition comprises a minimal amount of an Indenoisoquinolinone Analog to treat or prevent the Condition over a period of time. Advantages of controlled- or sustained-release compositions include extended activity of the drug, reduced dosage frequency, and increased subject compliance. In addition, controlled- or sustained-release compositions can favorably affect the time of onset of action or other characteristics, such as blood levels of the Indenoisoquinolinone Analog, and can thus reduce the occurrence of adverse side effects. 
     Controlled- or sustained-release compositions can initially release an amount of an Indenoisoquinolinone Analog that promptly produces the desired therapeutic or prophylactic effect, and gradually and continually release other amounts of the Indenoisoquinolinone Analog to maintain this level of therapeutic or prophylactic effect over an extended period of time. To maintain a constant level of the Indenoisoquinolinone Analog in the body, the Indenoisoquinolinone Analog can be released from the dosage form at a rate that will replace the amount of Indenoisoquinolinone Analog being metabolized and excreted from the body. Controlled- or sustained-release of an active ingredient can be stimulated by various conditions, including but not limited to, changes in pH, changes in temperature, concentration or availability of enzymes, concentration or availability of water, or other physiological conditions or compounds. 
     The amount of the Indenoisoquinolinone Analog that is effective in the treatment or prevention of a Condition can be determined by standard clinical techniques. In addition, in vitro or in vivo assays can optionally be employed to help identify optimal dosage ranges. The precise dose to be employed can also depend on the route of administration, and the seriousness of the condition being treated and can be decided according to the judgment of the practitioner and each subject&#39;s circumstances in view of, e.g., published clinical studies. Suitable effective dosage amounts, however, range from about 10 micrograms to about 5 grams about every 4 hours, although they are typically about 500 mg or less per every 4 hours. In one embodiment, the effective dosage is about 0.01 mg, 0.5 mg, about 1 mg, about 50 mg, about 100 mg, about 200 mg, about 300 mg, about 400 mg, about 500 mg, about 600 mg, about 700 mg, about 800 mg, about 900 mg, about 1 g, about 1.2 g, about 1.4 g, about 1.6 g, about 1.8 g, about 2.0 g, about 2.2 g, about 2.4 g, about 2.6 g, about 2.8 g, about 3.0 g, about 3.2 g, about 3.4 g, about 3.6 g, about 3.8 g, about 4.0 g, about 4.2 g, about 4.4 g, about 4.6 g, about 4.8 g, and about 5.0 g, every 4 hours. Equivalent dosages can be administered over various time periods including, but not limited to, about every 2 hours, about every 6 hours, about every 8 hours, about every 12 hours, about every 24 hours, about every 36 hours, about every 48 hours, about every 72 hours, about every week, about every two weeks, about every three weeks, about every month, and about every two months. The effective dosage amounts described herein refer to total amounts administered; that is, if more than one Indenoisoquinolinone Analog is administered, the effective dosage amounts correspond to the total amount administered. 
     Compositions can be prepared according to conventional mixing, granulating or coating methods, respectively, and the present compositions can contain, in one embodiment, from about 0.1% to about 99%; and in another embodiment from about 1% to about 70% of the Indenoisoquinolinone Analog by weight or volume. 
     The dosage regimen utilizing the Indenoisoquinolinone Analog can be selected in accordance with a variety of factors including type, species, age, weight, sex and medical condition of the subject; the severity of the condition to be treated; the route of administration; the renal or hepatic function of the subject; and the specific Indenoisoquinolinone Analog employed. A person skilled in the art can readily determine the effective amount of the drug useful for treating or preventing the Condition. 
     An Indenoisoquinolinone Analog can be administered in a single daily dose, or the total daily dosage can be administered in divided doses of two, three or four times daily. Furthermore, an Indenoisoquinolinone Analog can be administered in intranasal form via topical use of suitable intranasal vehicles, or via transdermal routes, using those forms of transdermal skin patches well known to those of ordinary skill in that art. To be administered in the form of a transdermal delivery system, the dosage administration can be continuous rather than intermittent throughout the dosage regimen. Other illustrative topical preparations include creams, ointments, lotions, aerosol sprays and gels, wherein the concentration of Indenoisoquinolinone Analog ranges from about 0.1% to about 15%, w/w or w/v. 
     The Indenoisoquinolinone Analogs can be assayed in vitro or in vivo for the desired therapeutic or prophylactic activity prior to use in humans. Animal model systems can be used to demonstrate safety and efficacy. 
     The present methods for treating or preventing a Condition in a subject in need thereof can further comprise administering another prophylactic or therapeutic agent to the subject being administered an Indenoisoquinolinone Analog. In one embodiment, the other prophylactic or therapeutic agent is administered in an effective amount. The other prophylactic or therapeutic agent includes, but is not limited to, an anti-inflammatory agent, an anti-renal failure agent, an anti-diabetic agent, and anti-cardiovasculare disease agent, an antiemetic agent, a hematopoietic colony stimulating factor, an anxiolytic agent, and an analgesic agent. 
     In one embodiment, the other prophylactic or therapeutic agent is an agent useful for reducing any potential side effect of an Indenoisoquinolinone Analog. Such potential side effects include, but are not limited to, nausea, vomiting, headache, low white blood cell count, low red blood cell count, low platelet count, headache, fever, lethargy, a muscle ache, general pain, bone pain, pain at an injection site, diarrhea, neuropathy, pruritis, a mouth sore, alopecia, anxiety or depression. 
     In one embodiment, the Indenoisoquinolinone Analog can be administered prior to, concurrently with, or after an anti-inflammatory agent, or on the same day, or within 1 hour, 2 hours, 12 hours, 24 hours, 48 hours or 72 hours of each other. 
     In another embodiment, the Indenoisoquinolinone Analog can be administered prior to, concurrently with, or after an anti-renal failure agent, or on the same day, or within 1 hour, 2 hours, 12 hours, 24 hours, 48 hours or 72 hours of each other. 
     In still another embodiment, the Indenoisoquinolinone Analog can be administered prior to, concurrently with, or after an anti-diabetic agent, or on the same day, or within 1 hour, 2 hours, 12 hours, 24 hours, 48 hours or 72 hours of each other. 
     In yet another embodiment, the Indenoisoquinolinone Analog can be administered prior to, concurrently with, or after an anti-cardiovascular disease agent, or on the same day, or within 1 hour, 2 hours, 12 hours, 24 hours, 48 hours or 72 hours of each other. 
     In a further embodiment, the Indenoisoquinolinone Analog can be administered prior to, concurrently with, or after an antiemetic agent, or on the same day, or within 1 hour, 2 hours, 12 hours, 24 hours, 48 hours or 72 hours of each other. 
     In another embodiment, the Indenoisoquinolinone Analog can be administered prior to, concurrently with, or after a hematopoietic colony stimulating factor, or on the same day, or within 1 hour, 2 hours, 12 hours, 24 hours, 48 hours, 72 hours, 1 week, 2 weeks, 3 weeks or 4 weeks of each other. 
     In still embodiment, the Indenoisoquinolinone Analog can be administered prior to, concurrently with, or after an opioid or non-opioid analgesic agent, or on the same day, or within 1 hour, 2 hours, 12 hours, 24 hours, 48 hours or 72 hours of each other. 
     In yet another embodiment, the Indenoisoquinolinone Analog can be administered prior to, concurrently with, or after an anxiolytic agent, or on the same day, or within 1 hour, 2 hours, 12 hours, 24 hours, 48 hours or 72 hours of each other. 
     Effective amounts of the other prophylactic or therapeutic agents are well known to those skilled in the art. However, it is well within the skilled artisan&#39;s purview to determine the other prophylactic or therapeutic agent&#39;s optimal effective amount range. In one embodiment of the invention, where another prophylactic or therapeutic agent is administered to a subject, the effective amount of the Indenoisoquinolinone Analog is less than its effective amount would be where the other prophylactic or therapeutic agent is not administered. In this case, without being bound by theory, it is believed that Indenoisoquinolinone Analogs and the other prophylactic or therapeutic agent act synergistically to treat or prevent a Condition. 
     In one embodiment, the other therapeutic or prophylactic agent is an anti-inflammatory agent. Anti-inflammatory agents useful in the methods of the present invention include but are not limited to adrenocorticosteroids, such as cortisol, cortisone, fludrocortisone, prednisone, prednisolone, 6α-methylprednisolone, triamcinolone, betamethasone, and dexamethasone; and non-steroidal anti-inflammatory agents (NSAIDs), such as aspirin, acetaminophen, indomethacin, sulindac, tolmetin, diclofenac, ketorolac, ibuprofen, naproxen, flurbiprofen, ketoprofen, fenoprofen, oxaprozin, mefenamic acid, meclofenamic acid, piroxicam, meloxicam, nabumetone, rofecoxib, celecoxib, etodolac, and nimesulide. 
     In one embodiment, the other therapeutic or prophylactic agent is an anti-renal failure agent. Anti-renal failure agents useful in the methods of the present invention include include but are not limited to ACE (angiotensin-converting enzyme) inhibitors, such as captopril, enalaprilat, lisinopril, benazepril, fosinopril, trandolapril, quinapril, and ramipril; diuretics, such as mannitol, glycerin, furosemide, toresemide, tripamide, chlorothiazide, methyclothiazide, indapamide, amiloride, and spironolactone; and fibric acid agents, such as clofibrate, gemfibrozil, fenofibrate, ciprofibrate, and bezafibrate. 
     In one embodiment, the other therapeutic or prophylactic agent is an anti-diabetic agent. Anti-diabetic agents useful in the methods of the present invention include include but are not limited to glucagons; somatostatin; diazoxide; sulfonylureas, such as tolbutamide, acetohexamide, tolazamide, chloropropamide, glybenclamide, glipizide, gliclazide, and glimepiride; insulin secretagogues, such as repaglinide, and nateglinide; biguanides, such as metformin and phenformin; thiazolidinediones, such as pioglitazone, rosiglitazone, and troglitazone; and α-glucosidase inhibitors, such as acarbose and miglitol. 
     In one embodiment, the other therapeutic or prophylactic agent is an anti-cardiovascular agent. Anti-cardiovascular disease agents useful in the methods of the present invention include include but are not limited to carnitine; thiamine; and muscarinic receptor antagonists, such as atropine, scopolamine, homatropine, tropicamide, pirenzipine, ipratropium, tiotropium, and tolterodine. 
     In one embodiment, the other therapeutic or prophylactic agent is an antiemetic agent. Antiemetic agents useful in the methods of the present invention include include, but are not limited to, metoclopromide, domperidone, prochlorperazine, promethazine, chlorpromazine, trimethobenzamide, ondansetron, granisetron, hydroxyzine, acetylleucine monoethanolamine, alizapride, azasetron, benzquinamide, bietanautine, bromopride, buclizine, clebopride, cyclizine, dimenhydrinate, diphenidol, dolasetron, meclizine, methallatal, metopimazine, nabilone, oxyperndyl, pipamazine, scopolamine, sulpiride, tetrahydrocannabinol, thiethylperazine, thioproperazine, tropisetron, and mixtures thereof. 
     In one embodiment, the other therapeutic or prophylactic agent is a hematopoietic colony stimulating factor. Hematopoietic colony stimulating factors useful in the methods of the present invention include, but are not limited to, filgrastim, sargramostim, molgramostim and epoietin alfa. 
     In one embodiment, the other therapeutic or prophylactic agent is an opioid analgesic agent. Opioid analgesic agents useful in the methods of the present invention include, but are not limited to, morphine, heroin, hydromorphone, hydrocodone, oxymorphone, oxycodone, metopon, apomorphine, normorphine, etorphine, buprenorphine, meperidine, lopermide, anileridine, ethoheptazine, piminidine, betaprodine, diphenoxylate, fentanil, sufentanil, alfentanil, remifentanil, levorphanol, dextromethorphan, phenazocine, pentazocine, cyclazocine, methadone, isomethadone and propoxyphene. 
     In one embodiment, the other therapeutic or prophylactic agent is a non-opioid analgesic agent. Non-opioid analgesic agents useful in the methods of the present invention include, but are not limited to, aspirin, celecoxib, rofecoxib, diclofinac, diflusinal, etodolac, fenoprofen, flurbiprofen, ibuprofen, ketoprofen, indomethacin, ketorolac, meclofenamate, mefanamic acid, nabumetone, naproxen, piroxicam and sulindac. 
     In one embodiment, the other therapeutic or prophylactic agent is an anxiolytic agent. Anxiolytic agents useful in the methods of the present invention include, but are not limited to, buspirone, and benzodiazepines such as diazepam, lorazepam, oxazapam, chlorazepate, clonazepam, chlordiazepoxide and alprazolam. 
     5.10 Kits 
     The invention encompasses kits that can simplify the administration of an Indenoisoquinolinone Analog to a subject. 
     A typical kit of the invention comprises a unit dosage form of an Indenoisoquinolinone Analog. In one embodiment, the unit dosage form is a container, which can be sterile, containing an effective amount of an Indenoisoquinolinone Analog and a physiologically acceptable carrier or vehicle. The kit can further comprise a label or printed instructions instructing the use of the Indenoisoquinolinone Analog to treat or prevent a Condition. The kit can also further comprise a unit dosage form of another prophylactic or therapeutic agent, for example, a container containing an effective amount of the other prophylactic or therapeutic agent. In one embodiment, the kit comprises a container containing an effective amount of an Indenoisoquinolinone Analog and an effective amount of another prophylactic or therapeutic agent. Examples of other prophylactic or therapeutic agents include, but are not limited to, those listed above. 
     The invention is further described in the following examples, which do not limit the scope of the invention described in the claims. 
     6. EXAMPLES 
     Example 1 
     Illustrative Indenoisoquinolinone Analogs 
     General Methods: 
       1 H-NMR spectra were obtained using Varian 300 MHz spectrophotometer and chemical shifts (6) are reported in parts per million (ppm).  1 H-NMR spectra were obtained using DMSO-d 6  or CDCl 3  as solvents. Analytical thin layer chromatography (TLC) was performed using TLC plates pre-coated with silica gel 60 F-254. Compounds were visualized with short wavelength UV light. All final compounds were characterized on the basis of  1 H-NMR or mass-spectrometry (MS) data. Homophthalic anhydride, 2-methyl-3-bromobenzoic acid, benzonitrile, and 3-methyl-4-bromobenzoic acid were obtained commercially (Sigma-Aldrich Corp., St. Louis, Mo.). 
     A. Synthesis of Indenoisocquinolinone Analogs of Formula Ia and IIIa 
     Methyl 3-bromo-2-methylbenzoate 
     2 mL of concentrated sulfuric acid were added to a solution of 3-bromo-2-methylbenzoic acid (20 g, 93 mmol) in methanol (150 mL). The resultant mixture was refluxed for 6 hours. Methanol was removed under reduced pressure, and the residue was dissolved in a mixture of chloroform (100 mL) and saturated solution of Na 2 CO 3  (100 mL). The organic layer was separated and washed with brine, dried over Na 2 SO 4  and concentrated to provide methyl 3-bromo-2-methylbenzoate (21.1 g).  1 H NMR spectrum (in DMSO-d 6 ): δ 7.79 (d, J=8.0 Hz, 1H); 7.69 (d, J=7.9 Hz, 1H); 7.23 (t, 1H); 3.82 (s, 3H). 
     Methyl 3-cyano-2-methylbenzoate 
     To a flask was added methyl 3-bromo-2-methylbenzoate (21 g, 91.7 mmol), potassium hexacyanoferrate (II) trihydrate (9.7 g, 22.9 mmol), Na 2 CO 3  (9.7 g, 91.7 mmol) and Pd(OAc) 2  (102 mg) in N,N-dimethylacetamide (100 mL). The flask&#39;s atmosphere was evacuated and replaced with nitrogen, and the reaction mixture heated at 120° C. for 10 hours. The reaction mixture was cooled to room temperature and diluted with ethyl acetate (150 mL). The resultant slurry was filtered and washed thoroughly with ethyl acetate (2×50 mL). The combined filtrate was washed with brine and water, dried over Na 2 SO 4  and evaporated under reduced pressure. The residue obtained after the concentration was purified using flash chromatography (ethyl acetate-hexanes (1:9) as the eluent) to provide methyl 3-cyano-2-methylbenzoate (11.2 g, 70% yield).  1 H NMR spectrum (in DMSO-d 6 ): δ 8.03 (d, J=8.1 Hz, 1H); 7.98 (d, J=7.9 Hz, 1H); 7.49 (t, 1H); 3.84 (s, 3H); 2.65 (s, 3H). 
     Methyl 2-bromomethyl-3-cyanobenzoate 
     A suspension of methyl 3-cyano-2-methylbenzoate (10.6 g, 60.5 mmol), NBS (16.2 g, 90.7 mmol) and azobisisobutyronitrile (AIBN) (100 mg) in tetrachloromethane (200 mL) was refluxed under nitrogen atmosphere for 6 hours. TLC analysis indicated the complete consumption of methyl 3-cyano-2-methylbenzoate (TLC solvent: 10% ethyl acetate in hexane). The reaction mixture was filtered and washed with chloroform (3×20 mL). The combined filtrate and washings were concentrated under reduced pressure. The residue was washed through a short column of silica gel using 10% ethyl acetate in hexanes as an eluent. The eluent was concentrated and the resultant product dried under vacuum overnight to provide 15.1 g of methyl 2-bromomethyl-3-cyanobenzoate (98% yield).  1 H NMR spectrum (in DMSO-d 6 ): δ 8.15 (d, J=8.0 Hz, 1H); 8.12 (d, J=7.9 Hz, 1H); 7.67 (t, 1H); 5.04 (s, 2H); 3.89 (s, 3H). 
     Methyl 5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline-10-carboxylate 
     A mixture of methyl 2-bromomethyl-3-cyanobenzoate (14.1 g, 55.5 mmol) and homophthalic anhydride (22.5 g, 138.8 mmol) in acetonitrile (150 mL) was stirred at room temperature. A solution of triethylamine (23.2 mL) in acetonitrile (100 mL) was added dropwise over the period of 1 hour. After the completion of addition, the resultant suspension was refluxed for 4 hours. The reaction mixture was then cooled to room temperature and filtered. The resultant solid was washed thoroughly with acetonitrile (100 mL) and ethanol (2×100 mL) and dried in vacuum oven at 50° C. to provide methyl 5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline-10-carboxylate was obtained in 81% yield (13.1 g).  1 H NMR spectrum (in DMSO-d 6 ): δ 12.21 (s, 1H); 8.20 (m, 2H); 7.83 (d, J=7.5 Hz, 1H); 7.71 (m, 2H); 7.47 (m, 2H); 4.07 (s, 2H); 3.89 (s, 3H). 
     10-Hydroxymethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline 
     Fine powder of methyl 5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline-10-carboxylate (11.3 g, 28.8 mmol) was suspended in THF (150 mL) and stirred at room temperature. A 2M solution of Lithium aluminium hydride (LAH) in THF (39 mL) was added slowly to the stirred suspension. After the complete addition, the mixture was stirred at room temperature for 6 hours, then cooled to 0° C. The reaction mixture was quenched with dropwise addition of ethyl acetate (50 mL). During the quenching the reaction temperature was kept below 50° C. The reaction mixture was poured into 1N HCl solution (200 mL) and stirred for 1 hour. The resultant solid was collected by filtration, washed with 1N HCl solution (20 mL) and ethyl acetate, and dried in a vacuum oven overnight to provide 10-hydroxymethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline in 93% yield (9.5 g).  1 H NMR spectrum (in DMSO-d 6 ): δ 12.28 (s, 1H); 8.23 (d, J=8.1 Hz, 1H); 7.89 (m, 1H); 7.73 (m, 2H); 7.45 (m, 1H); 7.36 (m, 2H); 5.22 (d, J=5.1 Hz, 1H), 4.68 (d, 2H); 3.85 (s, 2H). 
     10-Bromomethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline 
     Fine powder of 10-hydroxymethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline (7.3 g, 27.7 mmol) was suspended in THF (150 mL). A solution of PBr 3  (83 mL, 1M in dichloromethane) was added dropwise at room temperature. After the complete addition, the resultant mixture was stirred overnight and quenched by addition of water (150 mL). The suspension was stirred for 1 hour and filtered. The resultant solid was washed with water (2×100 mL) and ethyl acetate (2×100 mL) and dried in a vacuum oven to provide 110-Bromomethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline in 81% yield.  1 H NMR spectrum (in DMSO-d 6 ): δ 12.31 (s, 1H); 8.23 d, J=7.5 Hz, 1H); 7.95 (m, 1H); 7.75 (m, 2H); 7.45 (m, 2H); 4.87 (s, 2H); 3.97 (s, 2H). 
     General Procedure for the Amination Reaction: 
     A suspension of 10-bromomethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline (0.425 g, 1.3 mmol) or a higher alkylene chain bromo-derivative, an appropriate amine in ethanol or DMF and ethanol and in the presence of base is refluxed for 2 hrs to overnight. The reaction mixture is stirred at room temperature for about 30 minutes and filtered. The resultant solid is washed with ethanol (2×20 mL) and dried in a vacuum oven to provide an Indenoisoquinolinone Analog of Formula IIa or IIIa. 
     Methanesulfonate or Hydrochloride Salt Formation: 
     Free base of an Indenoisoquinolinone Analog of Formula IIb or IIIb is suspended in ethanol. To the stirred suspension, methanesulfonic acid or hydrochloric acid is added (2 to 10 equivalents). After some time, the resultant salt starts to precipitate from the solution. The mixture is stirred at room temperature for about 2 hours, filtered and washed with ethanol (2×20 mL). The filtered solid is dissolved in water (10 mL) and filtered. The filtrate is lyophilized to provide the corresponding salt of the free base of the Indenoisoquinolinone Analog of Formula Ia or IIIa. 
     B. Synthesis of Indenoisoquinolinone Analogs of Formula IIb and IIIb 
     Methyl 4-cyano-3-methylbenzoate 
     Methyl 4-cyano-3-methylbenzoate was obtained in 86% yield according to the procedure used to prepare methyl 3-cyano-2-methylbenzoate, except that methyl 4-bromo-3-methylbenzoate was used in place of methyl 3-bromo-2-methylbenzoate.  1 H NMR spectrum (in DMSO-d 6 ): δ 7.96 (s, 1H); 7.85 (m, 2H); 3.85 (s, 3H); 2.46 (s, 3H). 
     Methyl 3-bromomethyl-4-cyanobenzoate 
     Methyl 3-bromomethyl-4-cyanobenzoate was obtained in 60% yield according to the procedure used to prepare methyl 2-bromomethyl-3-cyanobenzoate (supra), except that methyl 4-cyano-3-methylbenzoate was used in place of methyl 3-cyano-2-methylbenzoate.  1 H NMR spectrum (in DMSO-d 6 ): δ 8.26 (s, 1H); 8.02 (s, 2H); 4.89 (s, 2H); 3.88 (s, 3H). 
     Methyl 5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline-9-carboxylate 
     Methyl 5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline-9-carboxylate was obtained in 65% yield according to the procedure used to prepare methyl 5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline-10-carboxylate, except that methyl 3-bromomethyl-4-cyanobenzoate was used in place of methyl 2-bromomethyl-3-cyanobenzoate.  1 H NMR spectrum (in DMSO-d 6 ): δ 12.35 (s, 1H); 8.25 (d, J=8.1 Hz, 1H); 8.11 (s, 1H); 8.06 (d, J=7.8 Hz, 1H); 7.98 (d, J=8.1 Hz, 1H); 7.75 (m, 2H); 7.49 (m, 1H); 3.95 (s, 2H); 3.85 (s, 3H). 
     9-Hydroxymethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline 
     9-Hydroxymethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline was obtained in 96% yield according to the procedure used to prepare 10-hydroxymethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline, except that methyl 5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline-9-carboxylate was used in place of methyl 5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline-10-carboxylate.  1 H NMR spectrum (in DMSO-d 6 ): δ 12.26 (s, 1H); 8.22 (d, J=8.1 Hz, 1H); 7.91 (s, J=8.1 Hz, 1H); 7.70 (m, 2H); 7.54 (s, 1H); 7.42 (m, 1H); 7.30 (d, J=8.1 Hz, 1H); 5.21 (d, 1H); 4.55 (d, J=5.4 Hz, 2H); 3.89 (s, 2H). 
     9-Bromomethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline 
     9-Bromomethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline was obtained in 65% yield according to the procedure used to prepare 10-bromomethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline, except that 9-hydroxymethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline was used in place of 10-hydroxymethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline.  1 H NMR spectrum (in DMSO-d 6 ): δ 12.24 (s, 1H); 8.23 (d, J=7.5 Hz, 1H); 7.94 (d, J=7.8 Hz, 1H); 7.72 (m, 2H); 7.65 (s, 1H); 7.45 (m, 2H); 4.79 (s, 2H); 3.89 (s, 2H). 
     General Procedure for the Amination Reaction: 
     A suspension of 9-bromomethyl-5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline (0.425 g, 1.3 mmol) or a higher alkylene chain bromo-derivative, an appropriate amine in ethanol or DMF and ethanol and in the presence of base is refluxed for 2 hrs to overnight. The reaction mixture is stirred at room temperature for about 30 minutes and filtered. The resultant solid is washed with ethanol (2×20 mL) and dried in a vacuum oven to provide an Indenoisoquinolinone Analog of Formula IIb or IIIb. 
     Methanesulfonate or Hydrochloride Salt Formation: 
     Free base of an Indenoisoquinolinone Analog of Formula IIb or IIIb is suspended in ethanol. To the stirred suspension, methanesulfonic acid or hydrochloric acid is added (2 to 10 equivalents). After some time, the resultant salt starts to precipitate from the solution. The mixture is stirred at room temperature for about 2 hours, filtered and washed with ethanol (2×20 mL). The filtered solid is dissolved in water (10 mL) and filtered. The filtrate is lyophilized to provide the corresponding salt of the free base of the Indenoisoquinolinone Analog of Formula IIb or IIIb. 
       1 H NMR data for illustrative Indenoisoquinolinone Analogs are presented below in Table 3. 
     
       
         
           
               
               
             
               
                 TABLE 3 
               
               
                   
               
               
                 Com- 
                   
               
               
                 pound 
                   1 H NMR (DMSO-d 6  or DMSO-d 6  and D 2 O) 
               
               
                   
               
             
            
               
                 IIa-1 
                 10-[1-(4-Allylpiperazino)methyl]-5,6-dihydro-5-oxo-11-H- 
               
               
                   
                 indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.28 (s, 1H); 
               
               
                   
                 8.23 (d, J = 8.1 Hz, 1H); 7.89 (d, J = 7.2 Hz, 1H); 7.75 (m, 2H); 
               
               
                   
                 7.45 (m, 1H); 7.37 (t, J = 7.5 Hz, 1H); 7.28 (d, J = 7.5 Hz, 1H); 
               
               
                   
                 5.77 (m, 1H); 5.14 (d, J = 18.6 Hz, 1H); 5.08 (d, J = 10.8 Hz, 
               
               
                   
                 1H); 3.89 (s, 2H); 3.61 (s, 2H); 2.89 (d, J = 6.0 Hz, 2H); 
               
               
                   
                 2.40 (m, 8H). MS: m/z = 372 (M +  − H) 
               
               
                 IIIa-2 
                 10-[1-(4-Butylpiperazino)methyl]-5,6-dihydro-5-oxo-11-H- 
               
               
                   
                 indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.28 (s, 1H); 
               
               
                   
                 8.24 (d, J = 7.8 Hz, 1H); 7.90 (d, J = 7.2 Hz, 1H); 7.74 (m, 2H); 
               
               
                   
                 7.45 (m, 1H); 7.36 (t, J = 7.5 Hz, 1H); 7.27 (d, J = 7.2 Hz, 1H); 
               
               
                   
                 3.90 (s, 2H); 3.64 (s, 2H); 2.38 (m, 10H); 1.41 (m, 2H); 1.24  
               
               
                   
                 (m, 2H); 0.85 (t, J = 7.2 Hz, 3H). MS: m/z = 388 (M +  − H). 
               
               
                 Dihydro- 
                 10-[1-(4-Allylpiperazino)methyl]-5,6-dihydro-5-oxo-11-H- 
               
               
                 chloride 
                 indeno[1,2-c]isoquinoline dihydrochloride:  1 H NMR (DMSO 
               
               
                 salt of  
                 &amp; D 2 O) δ 12.35 (s, 1H); 8.25 (d, J = 8.1 Hz, 1H); 8.04 (d, J = 
               
               
                 IIa-1 
                 7.5 Hz, 1H); 7.78 (t, J = 7.5 Hz, 1H); 7.72 (d, J = 7.5 Hz, 1H); 
               
               
                   
                 7.58 (s, 1H); 7.48 (m, 2H); 5.94 (m, 1H); 5.56 (d, J = 19.2 Hz, 
               
               
                   
                 1H); 5.48 (d, J = 10.5 Hz, 1H); 4.15 (s, 2H); 3.73 (s, 2H); 
               
               
                   
                 3.51 (m, 10H). 
               
               
                 Dihydro- 
                 10-[1-(4-Butylpiperazino)methyl]-5,6-dihydro-5-oxo-11-H- 
               
               
                 chloride 
                 indeno[1,2-c]isoquinoline dihydrochloride:  1 H NMR (DMSO 
               
               
                 salt of  
                 &amp; D 2 O) δ 12.35 (s, 1H); 8.25 (d, J = 8.1 Hz, 1H); 8.04 (d, J = 
               
               
                 IIIa-2 
                 7.2 Hz, 1H); 7.78 (t, J = 7.2 Hz, 1H); 7.71 (d, J = 7.2 Hz, 1H); 
               
               
                   
                 7.58 (s, 1H); 7.48 (m, 2H); 4.15 (s, 2H); 3.53 (m, 10H); 3.04 (s, 
               
               
                   
                 2H); 1.62 (m, 2H); 1.30 (m, 2H); 0.88 (t, J = 7.2 Hz, 3H). MS: 
               
               
                   
                 m/z = 388 (M +  − H). 
               
               
                 IIIa-3 
                 10-[1-(4-Cyclopropylmethylpiperazino)methyl]-5,6-dihydro- 
               
               
                   
                 5-oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 
               
               
                   
                 12.23 (s, 1H); 8.24 (d, J = 7.8 Hz, 1H); 7.90 (d, J = 7.2 Hz, 1H); 
               
               
                   
                 7.74 (m, 2H); 7.44 (m, 1H); 7.35 (t, J = 7.5 Hz, 1H); 7.27 (d, J = 
               
               
                   
                 7.2 Hz, 1H); 3.88 (s, 2H); 3.61 (s, 2H); 2.42 (m, 8H); 2.13 (d,  
               
               
                   
                 J = 5.7 Hz, 2H); 0.78 (m, 2H); 0.40 (d, J = 6.6 Hz, 2H); 0.02  
               
               
                   
                 (m, 2H). MS: m/z = 386 (M +  − H). 
               
               
                 IIa-14 
                 10-[(4,4-Ethylenedioxy-piperidino)methyl]-5,6-dihydro-5- 
               
               
                   
                 oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO): δ 
               
               
                   
                 12.28 (s, 1H); 8.24 (d, J = 7.8 Hz, 1H); 7.90 (d, J = 7.2 Hz, 1H); 
               
               
                   
                 7.76 (m, 2H); 7.45 (m, 1H); 7.36 (t, J = 7.5 Hz, 1H); 7.29 (d,  
               
               
                   
                 J = 7.2 Hz, 1H); 3.90 (s, 2H); 3.84 (s, 4H); 3.64 (s, 2H); 2.45  
               
               
                   
                 (m, 4H); 1.61 (m, 4H). MS: m/z 389 (M +  − H). 
               
               
                 IIIa-5 
                 10-[N-(2-Pyrollidinoethyl)aminomethyl}-5,6-dihydro-5-oxo- 
               
               
                   
                 11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.23 (s, 
               
               
                   
                 1H); 8.23 (d, J = 8.1 Hz, 1H); 7.88 (dd, J = 2.1 Hz, 6.3 Hz, 1H); 
               
               
                   
                 7.74 (d, J = 3.6 Hz, 2H); 7.44 (m, 1H); 7.34 (m, 2H); 3.89 (s, 
               
               
                   
                 2H); 3.87 (s, 2H); 2.62 (t, J = 6.3, 2H); 2.52 (m, 2H); 2.37 (m, 
               
               
                   
                 4H); 1.61 (m, 4H). MS: m/z 360 (M +  − H). 
               
               
                 IIa-27 
                 10-{N-[1-(Hydroxymethyl)cyclopentyl]aminomethyl}-5,6- 
               
               
                   
                 dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR 
               
               
                   
                 (DMSO) δ 12.28 (s, 1H); 8.23 (d, J = 7.8 Hz, 1H); 7.86 (d, J = 
               
               
                   
                 6.9 Hz, 1H); 7.73 (m, 2H); 7.45 (m, 1H); 7.36 (m, 2H); 4.56 (s, 
               
               
                   
                 1H); 3.90 (s, 2H); 3.79 (s, 2H); 3.41 (s, 2H); 1.69 (m, 2H); 
               
               
                   
                 1.53 (m, 4H). MS: m/z = 361 (M +  − H). 
               
               
                 IIIa-6 
                 10-{1-[4-(2-Pyrollidinoethyl)piperidino]methyl}-5,6-dihydro- 
               
               
                   
                 5-oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 
               
               
                   
                 12.24 (s, 1H); 8.24 (d, J = 7.8 Hz, 1H); 7.89 (d, J = 7.2 Hz, 1H); 
               
               
                   
                 7.75 (m, 2H); 7.45 (m, 1H); 7.35 (t, J = 7.2 Hz, 1H); 7.28 (d, J = 
               
               
                   
                 7.2 Hz, 1H); 3.89 (s, 2H); 3.58 (s, 2H); 2.79 (d, J = 9.9 Hz, 2H); 
               
               
                   
                 2.35 (m, 6H); 1.95 (t, J = 10.6 Hz, 2H); 1.62 (m, 6H); 1.33 (m, 
               
               
                   
                 3H); 1.12 (m, 2H). MS: m/z = 428 (M +  − H). 
               
               
                 IIIa-7 
                 10-{N-[4-(1-Methylpiperidyl)]aminomethyl}-5,6-dihydro-5- 
               
               
                   
                 oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 
               
               
                   
                 12.23 (s, 1H); 8.23 (d, J = 7.8 Hz, 1H); 7.87 (m, 1H); 7.75 (m, 
               
               
                   
                 2H); 7.46 (m, 1H); 7.36 (m, 2H); 3.90 (s, 2H); 3.88 (s, 2H); 
               
               
                   
                 2.68 (d, J = 11.7 Hz, 2H); 2.40 (m, 1H); 2.11 (s, 3H); 1.82  
               
               
                   
                 (m, 4H); 1.30 (m, 2H). 
               
               
                 IIIa-9 
                 10-[1-(4-Cyclopentylpiperazino)methyl]-5,6-dihydro-5-oxo- 
               
               
                   
                 11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.23 (s, 
               
               
                   
                 1H); 8.24 (d, J = 7.8 Hz, 1H); 7.90 (d, J = 7.2 Hz, 1H); 7.74 (m, 
               
               
                   
                 2H); 7.44 (m, 1H); 7.35 (t, J = 7.5 Hz, 1H); 7.28 (d, J = 7.2 Hz, 
               
               
                   
                 1H); 3.89 (s, 2H); 3.60 (s, 2H); 2.41 (m, 9H); 1.71 (m, 2H); 
               
               
                   
                 1.56 (m, 2H); 1.45 (m, 2H); 1.28 (m, 2H).  
               
               
                   
                 MS: m/z = 400 (M +  − H). 
               
               
                 IIIa-8 
                 10-{1-[4-(2-Pyrimidyl)piperazino]methyl}-5,6-dihydro-5-oxo- 
               
               
                   
                 11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.28 (s, 
               
               
                   
                 1H); 8.32 (d, J = 4.8, 2H); 8.24 (d, J = 7.8 Hz, 1H); 7.92 (d, J = 
               
               
                   
                 6.8 Hz, 1H); 7.74 (m, 2H); 7.44 (m, 1H); 7.35 (m, 2H); 6.59  
               
               
                   
                 (t, J = 4.8 Hz, 1H); 3.94 (s, 2H); 3.73 (m, 4H); 3.68 (s, 2H);  
               
               
                   
                 2.46 (m, 4H). MS: m/z = 410 (M +  − H). 
               
               
                 IIIa-10 
                 10-{1-[4-(2-Ethoxyethyl)piperazino]methyl}-5,6-dihydro-5- 
               
               
                   
                 oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 
               
               
                   
                 12.28 (s, 1H); 8.23 (d, J = 7.8 Hz, 1H); 7.90 (d, J = 7.2 Hz, 1H); 
               
               
                   
                 7.76 (m, 2H); 7.45 (m, 1H); 7.35 (t, J = 7.5 Hz, 1H); 7.27 (d, J = 
               
               
                   
                 7.2 Hz, 1H); 3.89 (s, 2H); 3.60 (s, 2H); 3.38 (m, 4H); 2.40 (m, 
               
               
                   
                 10H); 1.06 (t, J = 6.9 Hz, 3H). MS: m/z = 404 (M +  − H). 
               
               
                 IIb-1 
                 9-[1-(4-Allylpiperazino)methyl]-5,6-dihydro-5-oxo-11-H- 
               
               
                   
                 indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.23 (s, 1H); 
               
               
                   
                 8.22 (d, J = 7.8 Hz, 1H); 7.91 (d, J = 7.8 Hz, 1H); 7.71 (m, 2H); 
               
               
                   
                 7.51 (s, 1H); 7.44 (m, 1H); 7.28 (d, J = 7.5 Hz, 1H); 5.76 (m, 
               
               
                   
                 1H); 5.13 (d, J = 18.9 Hz, 1H); 5.08 (d, J = 11.2 Hz, 1H); 
               
               
                   
                 3.86 (s, 2H); 3.51 (s, 2H); 2.90 (d, J = 6.0 Hz, 2H); 2.37  
               
               
                   
                 (m, 8H). MS: m/z = 372 (M +  − H). 
               
               
                 IIIb-1 
                 9-[1-(4-iso-Propylpiperazino)methyl]-5,6-dihydro-5-oxo-11- 
               
               
                   
                 H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.22 (s, 
               
               
                   
                 1H); 8.23 (d, J = 7.8 Hz, 1H); 7.92 (d, J = 7.8 Hz, 1H); 7.71 (m, 
               
               
                   
                 2H); 7.50 (s, 1H); 7.43 (m, 1H); 7.28 (d, J = 7.8 Hz, 1H); 
               
               
                   
                 3.86 (s, 2H); 3.50 (s, 2H); 2.60 (m, 1H); 2.46-2.35 (m, 8H); 0.94  
               
               
                   
                 (d, J = 6.3 Hz, 6H). MS: m/z = 374 (M +  − H). 
               
               
                 IIIb-13 
                 9-[1-(4-Methylhomopiperazino)methyl]-5,6-dihydro-5-oxo- 
               
               
                   
                 11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.24 (s, 
               
               
                   
                 1H); 8.23 (d, J = 8.1 Hz, 1H); 7.91 (d, J = 7.8 Hz, 1H); 7.71 (m, 
               
               
                   
                 2H); 7.53 (s, 1H); 7.43 (m, 1H); 7.31 (d, J = 7.8 Hz, 1H); 
               
               
                   
                 3.86 (s, 2H); 3.65 (s, 2H); 2.66-2.50 (m, 8H); 2.25 (s, 3H); 1.71  
               
               
                   
                 (m, 2H). m/z = 360 (M +  − H). 
               
               
                 Dihydro- 
                 9-[1-(4-Cyclopropylmethylpiperazino)methyl]-5,6-dihydro-5- 
               
               
                 chloride 
                 oxo-11-H-indeno[1,2-c]isoquinoline dihydrochloride:  1 H 
               
               
                 salt of  
                 NMR (DMSO &amp; D 2 O) δ 8.22 (d, J = 7.8 Hz, 1H); 7.98 (t, J =  
               
               
                 IIIb-3 
                 7.5 Hz, 1H); 7.74 (m, 3H); 7.50 (m, 2H); 4.35 (s, 2H); 3.87 (s,  
               
               
                   
                 2H); 3.38 (m, 8H); 3.04 (d, J = 6.3 Hz, 2H); 1.02 (m, 1H); 0.62  
               
               
                   
                 (d, J = 6.3 Hz, 2H); 0.34 (m, 2H). MS: m/z = 386 (M +  − H). 
               
               
                 Dihydro- 
                 9-[1-(4-iso-Propylpiperazino)methyl]-5,6-dihydro-5-oxo-11- 
               
               
                 chloride 
                 H-indeno[1,2-c]isoquinoline dihydrochloride:  1 H NMR 
               
               
                 salt of  
                 (DMSO) δ 12.22 (s, 1H); 8.22 (d, J = 8.1 Hz, 1H); 7.99 (d, J = 
               
               
                 IIIb-1 
                 7.8 Hz, 1H); 7.75 (m, 3H); 7.56 (d, J = 7.8 Hz, 1H); 7.47 (m, 
               
               
                   
                 1H); 4.39 (s, 2H); 3.90 (s, 2H); 3.54 (m, 9H); 1.23 (d, J =  
               
               
                   
                 6.0 Hz, 6H). MS: m/z = 374 (M +  − H). 
               
               
                 IIIb-2 
                 9-[1-(4-Butylpiperazino)methyl]-5,6-dihydro-5-oxo-11-H- 
               
               
                   
                 indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.23 (s, 1H); 
               
               
                   
                 8.22 (d, J = 8.1 Hz, 1H); 7.91 (d, J = 7.8 Hz, 1H); 7.71 (m, 2H); 
               
               
                   
                 7.50 (s, 1H); 7.43 (m, 1H); 7.27 (d, J = 7.8 Hz, 1H); 3.86 (s, 
               
               
                   
                 2H); 3.50 (s, 2H); 2.35 (m, 8H); 2.22 (t, J = 6.9 Hz, 2H); 
               
               
                   
                 1.37-1.20 (m, 4H); 0.84 (t, J = 6.9 Hz, 3H).  
               
               
                   
                 MS: m/z = 388 (M +  − H). 
               
               
                 Dihydro- 
                 9-[1-(4-Butylpiperazino)methyl]-5,6-dihydro-5-oxo-11-H- 
               
               
                 chloride 
                 indeno[1,2-c]isoquinoline dihydrochloride:  1 H NMR (DMSO) 
               
               
                 salt of  
                 δ 12.23 (s, 1H); 8.23 (d, J = 7.8 Hz, 1H); 8.00 (d, J = 8.1 Hz, 
               
               
                 IIIb-2 
                 1H); 7.76 (m, 3H); 7.55 (d, J = 7.5 Hz, 1H); 7.48 (m, 1H); 
               
               
                   
                 4.36 (s, 2H); 3.91 (s, 2H); 3.40 (m, 8H); 3.09 (t, J = 7.5 Hz, 2H); 
               
               
                   
                 1.58 (m, 2H); 1.28 (m, 1H); 0.86 (t, J = 7.2 Hz, 3H).  
               
               
                   
                 MS: m/z = 388 (M +  − H). 
               
               
                 Dihydro- 
                 9-[1-(4-Allylpiperazino)methyl]-5,6-dihydro-5-oxo-11-H- 
               
               
                 chloride 
                 indeno[1,2-c]isoquinoline dihydrochloride:  1 H NMR (DMSO 
               
               
                 salt of 
                 &amp; D 2 O) δ 8.22 (d, J = 8.1 Hz, 1H); 7.97 (d, J = 7.8 Hz, 1H); 
               
               
                 IIb-1 
                 7.75 (m, 3H); 7.49 (m, 2H); 5.83 (m, 1H); 5.53 (d, J = 19.5 Hz, 
               
               
                   
                 1H); 5.08 (d, J = 9.6 Hz, 1H); 4.29 (s, 2H); 3.91 (s, 2H); 3.71  
               
               
                   
                 (d, J = 6.9 Hz, 2H); 3.32 (m, 8H). 
               
               
                 Dihydro- 
                 9-[1-(4-Cyclohexylpiperazino)methyl]-5,6-dihydro-5-oxo-11- 
               
               
                 chloride 
                 H-indeno[1,2-c]isoquinoline dihydrochloride:  1 H NMR 
               
               
                 salt of 
                 (DMSO &amp; D 2 O) δ 8.21 (d, J = 8.1 Hz, 1H); 7.94 (d, J = 7.8 Hz, 
               
               
                 IIIb-14 
                 1H); 7.75 (d, J = 3.9 Hz, 2H); 7.70 (s, 1H); 7.48 (m, 2H); 
               
               
                   
                 3.92 (s, 2H); 3.57 (s, 3H); 3.27 (m, 8H); 2.05 (s, 2H); 1.79 (d,  
               
               
                   
                 J = 10.8 Hz, 2H); 1.57 (d, J = 11.1 Hz, 1H); 1.43-1.05 (m, 5H). 
               
               
                 IIIb-24 
                 9-[1-(3,5-Dimethylpiperazino)methyl]-5,6-dihydro-5-oxo-11- 
               
               
                   
                 H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.22 (s, 
               
               
                   
                 1H); 8.22 (d, J = 7.8 Hz, 1H); 7.91 (d, J = 7.8 Hz, 1H); 7.71 (m, 
               
               
                   
                 2H); 7.49 (s, 1H); 7.44 (m, 1H); 7.28 (d, J = 7.8 Hz, 1H); 
               
               
                   
                 3.87 (s, 2H); 3.46 (s, 2H); 2.72 (m, 2H); 2.65 (d, J = 9.3 Hz,  
               
               
                   
                 2H); 1.49 (t, J = 10.1 Hz, 3H); 0.87 (d, J = 6.0 Hz, 6H).  
               
               
                   
                 MS: m/z = 360 (M +  − H). 
               
               
                 IIIb-17 
                 9-{1-[4-(2-Pyrollidinoethyl)piperidino]methyl}-5,6-dihydro- 
               
               
                   
                 5-oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 
               
               
                   
                 12.23 (s, 1H); 8.22 (d, J = 8.1 Hz, 1H); 7.91 (d, J = 7.5 Hz, 1H); 
               
               
                   
                 7.73 (m, 2H); 7.50 (s, 1H); 7.44 (m, 1H); 7.28 (d, J = 7.8 Hz, 
               
               
                   
                 1H); 3.87 (s, 2H); 3.48 (s, 2H); 2.79 (d, J = 11.1 Hz, 2H); 
               
               
                   
                 2.35 (m, 6H); 1.90 (t, J = 10.6 Hz, 2H); 1.62 (m, 6H); 1.33  
               
               
                   
                 (m, 3H); 1.15 (m, 2H). MS: m/z = 428 (M +  − H). 
               
               
                 IIb-92 
                 9-{N-[4-(1-Boc-piperidyl)]aminomethyl}-5,6-dihydro-5-oxo- 
               
               
                   
                 11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.23 (s, 
               
               
                   
                 1H); 8.23 (d, J = 7.8 Hz, 1H); 7.90 (d, J = 7.5 Hz, 1H); 7.71 (m, 
               
               
                   
                 2H); 7.57 (s, 1H); 7.43 (m, 1H); 7.34 (d, J = 7.5 Hz, 1H); 
               
               
                   
                 3.86 (s, 2H); 3.79 (m, 4H); 2.78 (m, 2H); 2.56 (m, 1H); 1.79  
               
               
                   
                 (d, J = 12.0 Hz, 2H); 1.37 (s, 9H); 1.15 (m, 2H).  
               
               
                   
                 MS: m/z = 446 (M +  − H). 
               
               
                 IIIb-9 
                 9-[1-(4-Cyclopentylpiperazino)methyl]-5,6-dihydro-5-oxo-11- 
               
               
                   
                 H-indeno[1,2-c]isoquinoline dihydrochloride:  1 H NMR 
               
               
                   
                 (DMSO) δ 12.22 (s, 1H); 8.22 (d, J = 8.1 Hz, 1H); 7.91 (d, J = 
               
               
                   
                 8.1 Hz, 1H); 7.71 (m, 2H); 7.51 (s, 1H); 7.44 (m, 1H); 7.28  
               
               
                   
                 (d, J = 7.5 Hz, 1H); 3.87 (s, 2H); 3.50 (s, 2H); 2.83 (m, 1H);  
               
               
                   
                 2.38 (m, 8H); 1.71 (m, 2H); 1.51 (m, 4H); 1.27 (m, 2H).  
               
               
                   
                 MS: m/z = 400 (M +  − H). 
               
               
                 IIIb-10 
                 9-{1-[4-(2-Ethoxyethyl)piperazino]methyl}-5,6-dihydro-5- 
               
               
                   
                 oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 
               
               
                   
                 12.28 (s, 1H); 8.23 (d, J = 7.8 Hz, 1H); 7.91 (d, J = 7.8 Hz, 1H); 
               
               
                   
                 7.71 (m, 2H); 7.51 (s, 1H); 7.43 (m, 1H); 7.29 (d, J = 7.8 Hz, 
               
               
                   
                 1H); 3.87 (s, 2H); 3.50 (s, 2H); 3.38 (m, 4H); 2.38 (m, 10H); 
               
               
                   
                 1.06 (t, J = 6.9 Hz, 3H). MS: m/z = 404 (M +  − H). 
               
               
                 IIb-196 
                 9-{1-[4-(2,2-Diethoxyethyl)piperazino]methyl}-5,6-dihydro- 
               
               
                   
                 5-oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 
               
               
                   
                 12.29 (s, 1H); 8.22 (d, J = 7.8 Hz, 1H); 7.91 (d, J = 7.8 Hz, 1H); 
               
               
                   
                 7.71 (m, 2H); 7.50 (s, 1H); 7.43 (m, 1H); 7.28 (d, J = 7.8 Hz, 
               
               
                   
                 1H); 4.54 (t, J = 4.8 Hz, 1H); 3.87 (s, 2H); 3.50 (m, 6H); 3.38 
               
               
                   
                 (m, 8H); 1.07 (t, J = 7.2 Hz, 3H). MS: m/z = 448 (M +  − H). 
               
               
                 IIb-53 
                 9-[(1-N-Methyl-3-morpholinopropyonyl)methyl]-5,6- 
               
               
                   
                 dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR 
               
               
                   
                 (DMSO) δ 12.28 (bs, 1H); 8.25 (d, J = 7.5 Hz, 1H); 7.98 (m, 
               
               
                   
                 1H); 7.76 (m, 2H); 7.51 (s, 1H); 7.47 (m, 1H); 7.26 (m, 1H); 
               
               
                   
                 4.67 (s, 1H); 4.59 (s, 1H); 3.83 (m, 2H); 3.58-3.49 (m, 4H); 
               
               
                   
                 2.96 (s, 2H); 2.84 (s, 1H); 2.73-2.32 (m, 8H). 
               
               
                 IIIb-16 
                 9-[(4-tert-Butoxycarbonyl-piperazino)methyl]-5,6-dihydro-5- 
               
               
                   
                 oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 
               
               
                   
                 12.29 (s, 1H); 8.25 (d, J = 7.5 Hz, 1H); 7.95 (d, J = 7.8 Hz, 1H); 
               
               
                   
                 7.74 (m, 2H); 7.48 (m, 2H); 7.32 (d, J = 7.8, 1H); 3.89 (s, 2H); 
               
               
                   
                 3.56 (s, 2H); 3.32 (m, 2H); 2.50 (m, 2H); 2.33 (m, 4H); 1.39  
               
               
                   
                 (s, 9H). 
               
               
                 IIb-105 
                 9-[(4-Propionyl-piperazino)methyl]-5,6-dihydro-5-oxo-11-H- 
               
               
                   
                 indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.32 (s, 1H); 
               
               
                   
                 8.25 (d, J = 7.5 Hz, 1H); 7.95 (d, J = 7.8 Hz, 1H); 7.75 (m, 2H); 
               
               
                   
                 7.55 (s, 1H); 7.47 (m, 1H); 7.33 (d, J = 8.1); 3.90 (s, 2H); 
               
               
                   
                 3.57 (s, 2H); 3.44 (m, 4H); 2.33 (m, 6H); 0.97 (t, J = 7.5, 3H).  
               
               
                   
                 MS: m/z = 388 (M +  − H). 
               
               
                 IIIb-18 
                 9-[4-(2-Hydroxy-2-methyl-propyl-piperazino)methyl]-5,6- 
               
               
                   
                 dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline 
               
               
                   
                 dihydrochloride:  1 H NMR (DMSO) δ 12.37 (s, 1H); 8.27 (d,  
               
               
                   
                 J = 7.8 Hz, 1H); 8.05 (m, 1H); 7.78 (m, 3H); 7.50 (m, 2H); 
               
               
                   
                 3.96 (s, 2H); 3.72-2.73 (m, 12H); 1.20 (s, 6H).  
               
               
                   
                 MS: m/z = 404 (M +  − H). 
               
               
                 IIb-118 
                 9-[(4-Propionyl-homopiperazino)methyl]-5,6-dihydro-5-oxo- 
               
               
                   
                 11-H-indeno[1,2-c]isoquinoline hydrochloride:  1 H NMR 
               
               
                   
                 (DMSO) δ 12.39 (s, 1H); 10.71 (bs, 1H); 8.27 (d, J = 8.1, 1H); 
               
               
                   
                 8.06 (d, J = 7.5 Hz, 1H); 7.81 (m, 3H); 7.64 (m, 1H); 7.51 (m, 
               
               
                   
                 1H); 4.42 (s, 2H); 4.15-2.99 (m, 14H); 0.99 (t, J = 7.2 Hz, 1H). 
               
               
                   
                 MS: m/z = 402 (M +  − H). 
               
               
                 Dihydro- 
                 9-[(1-N-Methyl-2-morpholino-aminoethyl)methyl]-5,6- 
               
               
                 chloride 
                 dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline 
               
               
                 salt of  
                 dihydrochloride:  1 H NMR (DMSO) δ 12.41 (s, 1H); 11.64 (bs, 
               
               
                 IIIb-19 
                 1H); 11.35 (bs, 1H); 8.27 (d, J = 6.9, 1H); 8.07 (d, J = 6.9, 1H); 
               
               
                   
                 7.90 (s, 1H); 7.74 (m, 3H); 7.51 (m, 1H); 4.62 (m, 1H); 4.39 (m, 
               
               
                   
                 1H); 3.96 (s, 2H); 3.83-3.17 (m, 12H); 2.73 (s, 3H).  
               
               
                   
                 MS: m/z = 390 (M +  − H). 
               
               
                 IIIa-11 
                 10-[S-(3-Fluoropyrrolidino)methyl]-5,6-dihydro-5-oxo-11-H- 
               
               
                   
                 indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.30 (s, 1H); 
               
               
                   
                 8.24 (d, J = 8.1 Hz, 1H); 7.91 (d, J = 7.5); 7.75 (m, 2H); 
               
               
                   
                 7.48-7.30 (m, 3H); 5.30 (m, 0.5H); 5.11 (m, 0.5H); 3.89 (s, 2H); 
               
               
                   
                 3.78 (s, 2H); 2.87-1.86 (m, 6H). MS: m/z = 335 (M +  − H). 
               
               
                 IIIa-12 
                 10-[(3,4-Dehydropiperidino)methyl]-5,6-dihydro-5-oxo-11- 
               
               
                   
                 H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.29 (s, 
               
               
                   
                 1H); 8.26 (d, J = 7.2 Hz, 1H); 7.93 (d, J = 6.6); 7.77 (m, 2H); 
               
               
                   
                 7.46-7.33 (m, 3H); 5.67 (m, 2H); 3.91 (s, 2H); 3.71 (s, 2H); 
               
               
                   
                 2.92 (m, 2H); 2.56 (m, 2H); 2.09 (m, 2H).  
               
               
                   
                 MS: m/z = 329 (M +  − H). 
               
               
                 IIIa-4 
                 10-[N-1-(3-Hydroxypropyl)aminomethyl]-5,6-dihydro-5-oxo- 
               
               
                   
                 11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.25 (s, 
               
               
                   
                 1H); 8.23 (d, J = 8.1 Hz, 1H); 7.87 (dd, J = 2.9 Hz, 5.9 Hz, 1H); 
               
               
                   
                 7.75 (m, 2H); 7.44 (m, 1H); 7.34 (m, 1H); 3.89 (s, 2H); 3.85 (s, 
               
               
                   
                 2H); 3.46 (t, J = 6.3 Hz, 2H); 2.60 (t, J = 6.9 Hz, 2H); 1.60 (m, 
               
               
                   
                 J = 6.3 Hz, 2H). MS: m/z = 321 (M +  − H). 
               
               
                 IIIa-1 
                 10-[1-(4-iso-Propylpiperazino)methyl]-5,6-dihydro-5-oxo-11- 
               
               
                   
                 H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.28 (s, 
               
               
                   
                 1H); 8.23 (d, J = 8.1 Hz, 1H); 7.90 (d, J = 7.5 Hz, 1H); 7.75 (m, 
               
               
                   
                 2H); 7.44 (m, 1H); 7.35 (t, J = 7.2 Hz, 1H); 7.27 (d, J = 7.2 Hz, 
               
               
                   
                 1H); 3.89 (s, 2H); 3.59 (s, 2H); 2.58 (m, 1H); 2.46-2.35 (m, 
               
               
                   
                 8H); 0.92 (d, J = 6.3 Hz, 6H). MS: m/z = 374 (M +  − H). 
               
               
                 IIa-40 
                 10-{1-[4-(1-pyrrolidinocarbonylmethyl)piperazino]methyl}- 
               
               
                   
                 5,6-dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR 
               
               
                   
                 (DMSO) δ 12.25 (s, 1H); 8.24 (d, J = 8.1 Hz, 1H); 7.90 (d,  
               
               
                   
                 J = 7.2 Hz, 1H); 7.76 (m, 2H); 7.45 (m, 1H); 7.36 (t, J = 7.8 Hz, 
               
               
                   
                 1H); 7.28 (d, J = 7.8 Hz, 1H); 3.90 (s, 2H); 3.62 (s, 2H); 3.44 (t, 
               
               
                   
                 J = 6.6 Hz, 2H); 3.24 (t, J = 6.9 Hz, 2H); 3.04 (s, 2H); 2.43 (m, 
               
               
                   
                 8H); 1.81 (m, 2H); 1.72 (m, 2H). MS: m/z = 443 (M +  − H). 
               
               
                 Dihydro- 
                 9-[1-(4-Methylhomopiperazino)methyl]-5,6-dihydro-5-oxo- 
               
               
                 chloride 
                 11-H-indeno[1,2-c]isoquinoline dihydrochloride:  1 H NMR 
               
               
                 salt of  
                 (DMSO) δ 12.35 (s, 1H); 8.23 (d, J = 7.8 Hz, 1H); 8.02 (d,  
               
               
                 IIIb-13 
                 J = 7.8 Hz, 1H); 7.84 (s, 1H); 7.76 (d, J = 3.3 Hz, 2H); 7.65  
               
               
                   
                 (d, J = 7.2 Hz, 1H); 7.47 (m, 1H); 4.42 (s, 2H); 3.92 (s, 2H);  
               
               
                   
                 3.32 (m, 8H); 2.76 (s, 3H); 2.19 (m, 2H).  
               
               
                   
                 MS: m/z = 360 (M +  − H). 
               
               
                 IIb-66 
                 9-{1-[4-(2-Cyanoethyl)piperazino]methyl}-5,6-dihydro-5- 
               
               
                   
                 oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 
               
               
                   
                 12.25 (s, 1H); 8.22 (d, J = 8.1 Hz, 1H); 7.92 (d, J = 7.5 Hz, 1H); 
               
               
                   
                 7.71 (m, 2H); 7.51 (s, 1H); 7.44 (m, 1H); 7.29 (d, J = 7.5 Hz, 
               
               
                   
                 1H); 3.87 (s, 2H); 3.52 (s, 2H); 2.62 (d, J = 6.1 Hz, 2H); 2.54 (d, 
               
               
                   
                 J = 6.1 Hz, 2H); 2.41 (m, 8H). MS: m/z = 385 (M +  − H). 
               
               
                 Methyl- 
                 9-[1-(4,4-Difluoropiperidino)methyl]-5,6-dihydro-5-oxo-11- 
               
               
                 sulfonate 
                 H-indeno[1,2-c]isoquinoline methylsulfonate:  1 H NMR 
               
               
                 salt of 
                 (DMSO) δ 12.36 (s, 1H); 9.75 (s, 1H); 8.25 (d, J = 8.1 Hz, 1H); 
               
               
                 IIIb-15 
                 8.06 (d, J = 8.1 Hz, 1H); 7.77 (m, 3H); 7.51 (m, 2H); 4.47 (s, 
               
               
                   
                 2H); 3.96 (s, 2H); 3.42 (m, 2H); 3.19 (m, 2H); 2.32 (s, 3H); 
               
               
                   
                 2.29 (m, 4H). MS: m/z = 367 (M +  − H). 
               
               
                 IIb-79 
                 9-{N-[4-(1-Boc-piperidyl)]-N-cyclopropylaminomethyl}-5,6- 
               
               
                   
                 dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR 
               
               
                   
                 (DMSO) δ 12.28 (s, 1H); 8.22 (d, J = 8.1 Hz, 1H); 7.88 (d,  
               
               
                   
                 J = 8.1 Hz, 1H); 7.71 (m, 2H); 7.48 (s, 1H); 7.43 (m, 1H); 7.27  
               
               
                   
                 (d, J = 7.8 Hz, 1H); 3.94 (m, 2H); 3.85 (s, 2H); 3.81 (s, 2H);  
               
               
                   
                 2.61 (m, 3H); 2.01 (m, 1H); 1.74 (m, 2H); 1.36 (m, 11H); 0.42  
               
               
                   
                 (m, 2H); 0.25 (m, 2H). MS: m/z = 486 (M +  − H). 
               
               
                 IIb-131 
                 9-{1-[4-(2-Furyl)piperazino]methyl}-5,6-dihydro-5-oxo-11-H- 
               
               
                   
                 indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.28 (s, 1H); 
               
               
                   
                 8.23 (d, J = 8.1 Hz, 1H); 7.92 (d, J = 7.8 Hz, 1H); 7.72 (m, 2H); 
               
               
                   
                 7.51 (s, 1H); 7.44 (m, 1H); 7.29 (d, J = 8.1 Hz, 1H); 3.88 (m, 
               
               
                   
                 3H); 3.68 (dt, J = 6.9 Hz, 7.5 Hz, 1H); 3.55 (dt, J = 6.9 Hz,  
               
               
                   
                 7.5 Hz, 1H); 3.51 (s, 2H); 2.37 (m, 10H); 1.86 (m, 1H); 1.73  
               
               
                   
                 (m, 2H); 1.45 (m, 1H). MS: m/z = 416 (M +  − H). 
               
               
                 IIb-157 
                 9-{1-[4-(1-Pyrrolidinocarbonylmethyl)piperazino]methyl}- 
               
               
                   
                 5,6-dihydro-5-oxo-11-H-indeno[1,2-c] isoquinoline:  1 H NMR 
               
               
                   
                 (DMSO) δ 12.27 (s, 1H); 8.23 (d, J = 7.8 Hz, 1H); 7.92 (d,  
               
               
                   
                 J = 8.1 Hz, 1H); 7.72 (m, 2H); 7.51 (s, 1H); 7.44 (m, 1H);  
               
               
                   
                 7.29 (d, J = 7.8 Hz, 1H); 3.88 (s, 2H); 3.51 (m, 2H); 3.43 (t,  
               
               
                   
                 J = 6.5 Hz, 2H); 3.24 (t, J = 6.6 Hz, 2H); 3.04 (s, 2H); 2.38 
               
               
                   
                 (m, 8H); 1.77 (m, 4H). MS: m/z = 443 (M +  − H). 
               
               
                 IIIb-20 
                 9-(N-4-Piperidylaminomethyl)-5,6-dihydro-5-oxo-11-H- 
               
               
                   
                 indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.35 (s, 1H); 
               
               
                   
                 9.67 (s, 2H); 9.04 (s, 1H); 8.90 (s, 1H); 8.25 (d, J = 7.8 Hz, 1H); 
               
               
                   
                 8.01 (d, J = 7.8 Hz, 1H); 7.83 (s, 1H); 7.77 (m, 2H); 7.63 (d,  
               
               
                   
                 J = 7.5 Hz, 1H); 7.48 (m, 1H); 4.23 (s, 2H); 3.94 (s, 2H); 3.32  
               
               
                   
                 (m, 3H); 2.90 (m, 2H); 2.27 (m, 2H); 1.92 (m, 2H).  
               
               
                   
                 MS: m/z = 346 (M +  − H). 
               
               
                 IIIb-8 
                 9-{1-[4-(2-Pyrimidyl)piperazino]methyl}-5,6-dihydro-5-oxo- 
               
               
                   
                 11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.29 (s, 
               
               
                   
                 1H); 8.32 (d, J = 5.1 Hz, 2H); 8.23 (d, J = 8.1 Hz, 1H); 7.94 (d, 
               
               
                   
                 J = 7.5 Hz, 1H); 7.72 (m, 2H); 7.57 (s, 1H); 7.45 (m, 1H); 7.34  
               
               
                   
                 (d, J = 7.5 Hz, 1H); 6.59 (t, J = 4.8 Hz, 1H); 3.89 (s, 2H); 3.72  
               
               
                   
                 (m, 4H); 3.58 (s, 2H); 2.44 (m, 4H). MS: m/z = 410 (M +  − H). 
               
               
                 IIb-170 
                 9-{1-[4-(Cyclopropylcarbonyl)piperazino]methyl}-5,6- 
               
               
                   
                 dihydro-5-oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR 
               
               
                   
                 (DMSO) δ 12.23 (s, 1H); 8.24 (d, J = 8.1 Hz, 1H); 7.94 (d,  
               
               
                   
                 J = 7.8 Hz, 1H); 7.72 (m, 2H); 7.55 (s, 1H); 7.45 (m, 1H); 7.33 
               
               
                   
                 (d, J = 7.2 Hz, 1H); 3.89 (s, 2H); 3.66 (m, 2H); 3.57 (s, 2H);  
               
               
                   
                 3.46 (m, 2H); 2.40 (m, 4H); 1.93 (m, 1H); 0.68 (m, 4H).  
               
               
                   
                 MS: m/z = 400 (M +  − H). 
               
               
                 IIIb-21 
                 9-{1-[4-(Trifluoromethyl)piperidino]methyl}-5,6-dihydro-5- 
               
               
                   
                 oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 
               
               
                   
                 12.23 (s, 1H); 8.23 (d, J = 7.8 Hz, 1H); 7.93 (d, J = 8.1 Hz, 1H); 
               
               
                   
                 7.72 (m, 2H); 7.52 (s, 1H); 7.44 (m, 1H); 7.30 (d, J = 7.8 Hz, 
               
               
                   
                 1H); 3.87 (s, 2H); 3.54 (s, 2H); 2.89 (d, J = 11.3 Hz, 2H); 
               
               
                   
                 2.21 (m, 1H); 1.97 (t, J = 11.5 Hz, 2H); 1.76 (d, J = 11.6 Hz,  
               
               
                   
                 2H); 1.45 (m, 2H). MS: m/z = 399 (M +  − H). 
               
               
                 IIIb-22 
                 9-(1-Homopiperidinomethyl)-5,6-dihydro-5-oxo-11-H- 
               
               
                   
                 indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.18 (s, 1H); 
               
               
                   
                 8.23 (d, J = 7.8 Hz, 1H); 7.90 (d, J = 7.8 Hz, 1H); 7.71 (m, 2H); 
               
               
                   
                 7.54 (s, 1H); 7.43 (m, 1H); 7.31 (d, J = 7.8 Hz, 1H); 3.86 (s, 
               
               
                   
                 2H); 3.65 (2, H); 2.57 (m, 4H), 1.57 (m, 8H).  
               
               
                   
                 MS: m/z = 345 (M +  − H). 
               
               
                 IIb-183 
                 9-[1-(4-Octylpiperazino)methyl]-5,6-dihydro-5-oxo-11-H- 
               
               
                   
                 indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 12.28 (s, 1H); 
               
               
                   
                 8.23 (d, J = 8.1 Hz, 1H); 7.93 (d, J = 7.8 Hz, 1H); 7.72 (m, 2H); 
               
               
                   
                 7.53 (s, 1H); 7.44 (m, 1H); 7.31 (d, J = 7.2 Hz, 1H); 3.88 (s, 
               
               
                   
                 2H); 3.58 (s, 2H); 2.87 (m, 4H); 2.41 (m, 6H); 1.55 (m, 2H), 
               
               
                   
                 1.23 (m, 10H); 0.84 (t, J = 6.9 Hz, 3H).  
               
               
                   
                 MS: m/z = 444 (M +  − H). 
               
               
                 IIIb-23 
                 9-{1-[4-(3-Hydroxypropyl)piperazino]methyl}-5,6-dihydro-5- 
               
               
                   
                 oxo-11-H-indeno[1,2-c]isoquinoline:  1 H NMR (DMSO) δ 
               
               
                   
                 12.27 (s, 1H); 8.22 (d, J = 7.5 Hz, 1H); 7.92 (d, J = 7.8 Hz, 1H); 
               
               
                   
                 7.71 (m, 2H); 7.51 (s, 1H); 7.44 (m, 1H); 7.27 (d, J = 7.8 Hz, 
               
               
                   
                 1H); 3.87 (s, 2H); 3.51 (s, 2H); 3.40 (t, J = 6.3 Hz, 2H); 2.37  
               
               
                   
                 (m, 10H); 1.53 (t, J = 6.3 Hz, 3H). MS: m/z = 390 (M +  − H). 
               
               
                 IIb-40 
                 9-((4-(2-oxo-2-(pyrrolidin-1-yl)ethyl)piperazin-1- 
               
               
                   
                 yl)methyl)-6,11-dihydro-5H-indeno[1,2-c]isoquinolin- 
               
               
                   
                 5-one:  1 H NMR (DMSO-d 6 ): δ 12.27 
               
               
                   
                 (s, 1H); 8.23 (d, J = 7.8 Hz, 1H); 7.92 (d, J = 8.1 Hz, 1H); 
               
               
                   
                 7.72 (m, 2H); 7.51 (s, 1H); 7.43 (t, J = 7.8 Hz, 1H); 7.29 (d,  
               
               
                   
                 J = 7.8 Hz, 1H); 3.87 (s, 2H); 3.51 (s, 2H); 3.43 (t,  
               
               
                   
                 J = 6.6 Hz, 2H); 3.24 (t, J = 6.6 Hz, 2H); 3.04 (s, 2H);  
               
               
                   
                 2.38 (m, 8H); 1.80 (m, 2H); 1.72 (m, 2H). 
               
               
                 IIb-27 
                 9-((1-(hydroxymethyl)cyclopentylamino)methyl)- 
               
               
                   
                 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one: 
               
               
                   
                   1 H NMR (DMSO-d 6 ): δ 12.35 (s, 1H); 8.86 (s, 2H); 8.26 
               
               
                   
                 (d, J = 8.1 Hz, 1H); 8.03 (d, J = 7.2 Hz, 1H); 7.78 (m, 
               
               
                   
                 3H); 7.55 (m, 2H); 5.74 (s, 1H); 4.19 (s, 2H); 3.97 (s, 2H); 
               
               
                   
                 3.58 (s, 2H); 1.76 (m, 6H); 1.58 (m, 2H).  
               
               
                   
                 MS: m/z 361 (M − H + ). 
               
               
                 IIb-210 
                 9-((4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)methyl)- 
               
               
                   
                 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one:  
               
               
                   
                   1 H NMR (DMSO-d 6 ): δ 12.24 (s, 1H); 
               
               
                   
                 8.22 (d, J = 8.1 Hz, 1H); 7.91 (d, J = 7.5 Hz, 1H); 
               
               
                   
                 7.70 (m, 2H); 7.50 (s, 1H); 7.43 (t, J = 7.8 Hz, 1H); 7.27 (d, J =  
               
               
                   
                 7.8 Hz, 1H); 3.86 (s, 2H); 3.48 (s, 2H); 2.78 (d, J = 11.1 Hz,  
               
               
                   
                 2H); 2.35 (m, 6H); 1.89 (t, J = 10.6 Hz, 2H); 1.62 (m, 6H);  
               
               
                   
                 1.35 (m, 3H); 1.15 (m, 2H). MS: m/z 428 (M − H + ). 
               
               
                 IIa-28 
                 10-((1-hydroxymethyl)cyclopentylamino)methyl)benzofuro[3,2- 
               
               
                   
                 c]isoquinolin-5(6H)-one:  1 H NMR (DMSO-d 6 ): δ 12.52 (s, 1H); 
               
               
                   
                 9.16 (s, 2H); 8.35 (d, J = 8.1 Hz, 1H); 8.08 (m, 2H); 7.94 (t, J =  
               
               
                   
                 7.5 Hz, 1H); 7.69 (t, J = 7.2 Hz, 1H); 7.63 (d, J = 7.8 Hz, 1H);  
               
               
                   
                 7.46 (t, J = 7.5 Hz, 1H); 5.85 (s, 1H); 4.51 (s, 2H); 3.68 (s, 2H);  
               
               
                   
                 1.91 (m, 5H); 1.79 (m, 2H); 1.63 (m, 2H). 
               
               
                 Va-1 
                 4-chloro-10-((cyclopentylamino)methyl)-6,11-dihydro-5H- 
               
               
                   
                 indeno[1,2-c]isoquinolin-5-one  1 H NMR (DMSO-d 6 ).: δ 8.94 
               
               
                   
                 (bs, 2H), 8.13 (m, 1H), 7.85 (m, 2H), 7.51 (m, 3H), 4.39 (m,  
               
               
                   
                 2H), 4.10 (s, 2H), 3.67 (m, 1H), 2.07 (m, 2H), 1.65 (m, 4H),  
               
               
                   
                 1.54 (m, 2H). MS: m/z 365.2 (M − H + ). 
               
               
                 Va-2 
                 10-((cyclopentylamino)methyl)-2-fluoro-6,11-dihydro-5H- 
               
               
                   
                 indeno[1,2-c]isoquinolin-5-one  1 H NMR (DMSO-d 6 ).: δ  
               
               
                   
                 12.46 (bs, 1H), 8.95 (bs, 2H), 8.32 (dd, J = 6.0, 
               
               
                   
                 6.0 Hz, 1H), 8.07 (dd, J = 2.0, 5.0 Hz, 1H), 
               
               
                   
                 7.54 (m, 3H), 7.33 (dd, J = 6.0, 6.0 Hz, 1H), 4.29 (m, 2H), 
               
               
                   
                 4.06 (s, 2H), 3.65 (m, 1H), 2.06 (m, 2H), 1.72 (m, 4H),  
               
               
                   
                 1.58 (m, 2H). MS: m/z 349.0 (M − H + ). 
               
               
                 Va-3 
                 10-((cyclopentylamino)methyl)-3-fluoro-6,11-dihydro-5H- 
               
               
                   
                 indeno[1,2-c]isoquinolin-5-one  1 H NMR (DMSO-d 6 ).: δ  
               
               
                   
                 12.53 (bs, 1H); 8.95 (bs, 2H), 8.04 (dd, J = 6.0, 7.2 Hz,  
               
               
                   
                 1H), 7.98 (m, 1H), 7.73 (m, 1H), 7.51 (m, 2H), 4.31  
               
               
                   
                 (dd, J = 5.2, 5.2 Hz, 2H), 4.06 (s, 2H), 
               
               
                   
                 3.65 (m, 1H), 2.07 (m, 2H), 1.72 (m, 4H), 1.57 (m, 2H).  
               
               
                   
                 MS: m/z 348.9 (M − H + ). 
               
               
                 Va-4 
                 10-((cyclopentylamino)methyl)-4-fluoro-6,11-dihydro-5H- 
               
               
                   
                 indeno[1,2-c]isoquinolin-5-one  1 H NMR (DMSO-d 6 ).: δ 12.37 
               
               
                   
                 (bs,1H), 8.86 (bs, 2H); 8.05 (dd, J = 2.0, 6.8 Hz, 1H), 7.77 
               
               
                   
                 (m, 1H), 7.54 (m, 3H); 7.23 (m, 1H); 4.30 (dd, J = 6.0, 6.0 Hz,  
               
               
                   
                 2H); 4.04 (s, 2H); 3.65 (m, 1H); 2.31 (m, 2H); 1.71 (m, 4H);  
               
               
                   
                 1.57 (m, 2H). MS: m/z 348.9 (M − H + ) 
               
               
                 Va-5 
                 3-fluoro-10-((tetrahydro-2H-pyran-4-ylamino)methyl)- 
               
               
                   
                 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one  
               
               
                   
                   1 H NMR (DMSO-d 6 ).: δ 12.47 (bs, 1H), 
               
               
                   
                 8.85 (bs, 2H), 7.98 (d, J = 6.5 Hz, 2H), 7.67 (m, 1H), 
               
               
                   
                 7.44 (m, 3H), 4.38 (m, 2H), 4.27 (m, 2H), 3.99 (dd, J =  
               
               
                   
                 3.6, 11.6 Hz, 2H), 3.53 (m, 2H), 3.42 (m, 1H), 2.01 (m, 2H),  
               
               
                   
                 1.58 (m, 2H) MS: m/z 365.30 (M − H+). 
               
               
                 Va-6 
                 1-fluoro-10-((tetrahydro-2H-pyran-4-ylamino)methyl)- 
               
               
                   
                 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one  
               
               
                   
                   1 H NMR (DMSO-d 6 ).: δ 12.49 (bs, 1H), 
               
               
                   
                 8.93 (bs, 2H). 8.65 (m, 1H), 7.95 (dd, J = 2.0,  
               
               
                   
                 8.9 Hz, 1H), 7.89 (dd, J = 2.5, 8.9, 1H), 7.75 (m, 2H), 7.42 (dd,  
               
               
                   
                 J = 4.0, 8.0 Hz, 1H), 5.81 (bs, 1H), 4.28 (m, 2H), 4.07 (s, 2H),  
               
               
                   
                 3.65 (m, 2H), 3.49 (m, 1H), 1.84 (m, 8H).  
               
               
                   
                 MS: m/z 379.2 (M − H + ) 
               
               
                 Va-7 
                 10-((cyclopentylamino)methyl)-1-fluoro-6,11-dihydro-5H- 
               
               
                   
                 indeno[1,2-c]isoquinolin-5-one  1 H NMR (DMSO-d 6 ).: δ 12.58  
               
               
                   
                 (bs, 1H), 8.94 (bs, 2H), 8.13 (d, J = 2.8, 7,6 Hz, 2H), 7.65 (m,  
               
               
                   
                 1H), 7.51 (m, 3H), 4.34 (dd, J = 6.0, 6.0 Hz, 2H), 4.20 (s, 2H),  
               
               
                   
                 3.67 (m, 1H), 2.07 (m, 2H), 1.69 (m, 4H), 1.57 (m, 2H).  
               
               
                   
                 MS: m/z 348.9 (M − H + ). 
               
               
                 Va-8 
                 2-fluoro-10-((tetrahydro-2H-pyran-4-ylamino)methyl)- 
               
               
                   
                 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one  
               
               
                   
                   1 H NMR (DMSO-d 6 ).: δ 12.70 (bs, 1H), 
               
               
                   
                 9.16 (bs, 2H), 8.57 (m, 1H), 8.33 (m, 1H), 7.77 (m, 3H),  
               
               
                   
                 7.55 (m, 1H), 4.60 (m, 2H), 4.27 (m, 2H), 4.21 (m, 2H),  
               
               
                   
                 3.65 (m, 2H), 3.55 (m, 1H), 2.31 (m, 2H), 1.92 (m, 2H).  
               
               
                   
                 MS: m/z 365.3 (M − H + ). 
               
               
                 Va-9 
                 8-fluoro-10-((1-(hydroxymethyl)cyclopentylamino)methyl)- 
               
               
                   
                 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one  1 H NMR  
               
               
                   
                 (DMSO-d 6 ).: δ 12.59 (bs, 1H), 8.90 (bs, 2H);  
               
               
                   
                 8.12 (d, J = 8.0 Hz, 2H), 7.65 (m, 1H), 7.52 (m, 3H), 
               
               
                   
                 4.38 (m, 2H), 4.20 (s, 2H), 3.97 (dd J = 2.0, 
               
               
                   
                 10 Hz, 2H), 3.55 (m, 2H), 3.42 (m, 1H), 2.13 (m, 2H);  
               
               
                   
                 1.65 (m, 2H). MS: m/z 365.3 (M − H + ). 
               
               
                 Va-10 
                 3,8-difluoro-10-((1-(hydroxymethyl)cyclopentylamino)methyl)- 
               
               
                   
                 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one  1 H NMR 
               
               
                   
                 (DMSO-d 6 ).: δ 12.49 (bs, 1H); 9.12 (bs, 2H), 8.66 (m, 1H),  
               
               
                   
                 7.96 (m, 2H), 7.89 (m, 1H); 7.75 (m, 1H), 5.84 (bs, 1H), 4.28  
               
               
                   
                 (m, 2H), 4.07 (s, 2H), 3.65 (m, 2H); 3.45 (m, 1H), 1.84 (m, 4H),  
               
               
                   
                 1.64 (m, 4H). MS: m/z 397.2 (M − H + ). 
               
               
                   
               
            
           
         
       
     
     Example 2 
     Determination of the Effect of Indenoisoquinolinone Analogs on in vitro PARP Activity 
     The ability of an illustrative Indenoisoquinolinone Analog to inhibit PARP and prevent peroxynitrite induced cytotoxicity can be demonstrated using methods described in Virag et al.,  Br. J. Pharmacol.  1999, 126(3):769-77; and Immunology 1998, 94(3):345-55. 
     The potency of inhibition of purified PARP enzyme can be subsequently determined for selected Indenoisoquinolinone Analogs, and the potency is compared with that of 3-aminobenzamide, a prototypical benchmark PARP inhibitor. The assay is performed in 96 well ELISA plates according to instructions provided with a commercially available PARP inhibition assay kit (for example, from Trevigen, Gaithersburg, Md.). 
     Example 3 
     Determination of the Effect of Indenoisoquinolinone Analogs in an In Vitro Model of Cell Death 
     Using an in vitro, oxidant-stimulated thymocyte assay (described, in detail, in Virag et al.,  Immunology  94(3):345-55, 1998), an illustrative Indenoisoquinolinone Analog can be tested for its ability to prevent the oxidant-induced suppression of the viability of the cells and as such, this assay represents an in vitro model of reperfusion related cell death in ischemic organs. 
     Example 4 
     Determination of the Effect of Indenoisoquinolinone Analogs on in vivo Models of Inflammatory Diseases 
     The effect of an illustrative Indenoisoquinolinone Analog can be determined using a systemic inflammatory model induced by bacterial lipopolysaccharide (LPS), which is reported to be responsible for causing reperfusion injurys and inflammatory diseases such as septic shock and systemic inflammatory response syndrome in animals (see Parrillo,  N. Engl. J. Med.,  328:1471-1478 (1993) and Lamping,  J. Clin. Invest.  101:2065-2071 (1998). 
     Example 5 
     Determination of the Effect of Indenoisoquinolinone Analogs on In Vivo Models of Reperfusion injury 
     The efficacy of an illustrative Indenoisoquinolinone Analog in a mouse model of ischemic and reperfused gut can be determined according to the method described in Liaudet et al.,  Shock  2000, 14(2):134-41. 
     In another set of experiments, the effect of an illustrative Indenoisoquinolinone Analog in a rat model of middle cerebral artery occlusion/reperfusion can be assayed as described in Abdelkarim et al,  Int. J. Mol. Med.  2001, 7(3):255-60. 
     Example 6 
     Determination of the Effect of Indenoisoquinolinone Analogs in an In Vivo Model of Diabetes Mellitus 
     PARP inhibitors and PARP deficiency are known to reduce the development of diabetes mellitus and the incidence of diabetic complications. The anti-diabetic effect of an illustrative Indenoisoquinolinone Analog can be determined using a single high-dose streptozotocin model of diabetes mellitus, which can be used as conducted as described in Mabley et al.,  Br. J. Pharmacol.  2001, 133(6):909-9; and Soriano et al.,  Nat. Med.  2001, 7(1): 108-13. Briefly, 160 mg/kg streptozotocin is injected to mice treated with vehicle (control) or with an illustrative Indenoisoquinolinone Analog intraperitoneally (3 mg/kg) and 3 days later blood sugar levels are determined using a blood glucose meter. 
     Example 7 
     Determination of the Effect of Indenoisoquinolinone Analogs in an In Vivo Model of Erectile Dysfunction 
     Experiments are conducted in male Sprague-Dawley rats according to previously published methods for forceps-induced nerve crush injury and erectile function measurements (Rehman, J., et al.,  Urology  51:640-644, 1998; Sezen, S. F., et al.,  Int. J. Impot. Res.  14:506-12, 2002). Subjects are anesthetized with Phenobarbital. The prostate of the subjects is exposed and the cavernosal nerve is clipped on either side with a forceps to induce mechanical injury (crush). This rat model mimics the nerve injury that develops during human male prostatectomy, leading to nerve injury and subsequent erectile dysfunction. Subjects are studied 2 weeks after the injury. Two groups of subjects are used, one group treated with vehicle and one group treated with an illustrative Indenoisoquinolinone Analog. The illustrative Indenoisoquinolinone Analog is injected at 30 mg/kg i.v. immediately before the crush injury, and on the following day at the same dose. Thereafter, for 12 days, subjects are treated with 60 mg/kg of the illustrative Indenoisoquinolinone Analog intraperitoneally. At 2 weeks, subjects are re-anesthetized and measured for mean arterial blood pressure (MAP) and intracavernosal pressure (ICP). Cavernosal nerve stimulation is conducted at 5 and 7.5 V using a square pulse stimulator for 30 msec. ICP is determined as the area under curve (mmHg×sec). In addition, IPC/MAP ratios are determined. 
     Example 8 
     Effect of Indenoisoquinolinone Analogs on PARP Activity in Cultured Macrophages, Using a Whole-Cell Based Assay 
     Demonstration of Indenoisoquinolinone Analogs&#39; ability to inhibit PARP and prevent peroxynitrite induced cytotoxicity was shown using methods described in Virag et al.,  Br. J. Pharmacol.  1999, 126(3):769-77; and  Immunology  1998, 94(3):345-55. The murine RAW macrophages (ATCC, American Type Culture Collection, Manassas, Va.) were grown in RPMI 1650 (Invitrogen Life Technologies; Carlsbad, Calif.) medium supplemented with 10% heat-inactivated FBS, 2 mM L-glutamine, and 100 U/ml of penicillin and streptomycin. Cells, between passages 5 and 15, were seeded at a density of 250,000 cells/well in 12 well plates and allowed to grow 48 hours before use. Growth medium was changed on the day of use. Cells were treated with an Indenoisoquinolinone Analog diluted in a growth medium supplemented with 10% fetal bovine serum (FBS) for 1 hour prior to the addition of hydrogen peroxide (0.5 mM) for a further 25 minutes. For the measurement of PARP activity, media was removed and replaced with 0.5 ml of the assay buffer (56 mM HEPES-pH 7.5, 28 mM KCl, 28 mM NaCl, 2 mM MgCl 2 , 0.01% digitonin, and 0.5 μCi/ml of 3H-NAD + ) for 20 minutes. After aspirating the assay buffer, cells were lysed and transferred to eppendorf tubes containing 250 μl of 50% ice-cold trichloroacetic acid (TCA), which were then placed at 4° C. for 4 hours. Samples were centrifuged at 10,000 g for 10 minutes and supernatant removed. The pellets were washed twice with 500 μl of ice-cold 5% w/v TCA. The pellets were then solubilized in 250 μl of NaOH (0.1 M) containing 2% SDS overnight at 37° C. and the PARP activity was then determined by measuring the radioactivity incorporated using a Wallac scintillation counter. The solubilized protein (250 μl) was mixed with 5 ml of scintillation fluid (ScintiSafe Plus, Fisher Scientific) before being counted for 3 minutes. EC 50  values were determined from a dose-response curve. 
     
       
         
           
               
               
               
             
               
                 TABLE 4 
               
               
                   
               
               
                   
                 Compound 
                 EC 50  value [nM] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 IIa-1 
                 20 
               
               
                   
                 IIa-14 
                 30 
               
               
                   
                 IIa-27 
                 &lt;10 
               
               
                   
                 IIIa-2 
                 25 
               
               
                   
                 IIIa-3 
                 20 
               
               
                   
                 IIIa-4 
                 15 
               
               
                   
                 IIIa-5 
                 40 
               
               
                   
                 IIIa-6 
                 50 
               
               
                   
                 IIIa-7 
                 60 
               
               
                   
                 IIIa-8 
                 75 
               
               
                   
                 IIIa-9 
                 60 
               
               
                   
                 IIIa-10 
                 60 
               
               
                   
                 IIIa-11 
                 12 
               
               
                   
                 IIIa-12 
                 7 
               
               
                   
                 IIb-1 
                 45 
               
               
                   
                 IIb-53 
                 &gt;50 
               
               
                   
                 IIb-66 
                 45 
               
               
                   
                 IIb-79 
                 &gt;60 
               
               
                   
                 IIb-92 
                 &gt;60 
               
               
                   
                 IIb-105 
                 100 
               
               
                   
                 IIb-118 
                 60 
               
               
                   
                 IIb-170 
                 75 
               
               
                   
                 IIb-131 
                 75 
               
               
                   
                 IIb-196 
                 75 
               
               
                   
                 IIb-183 
                 100 
               
               
                   
                 IIb-157 
                 75 
               
               
                   
                 IIIb-1 
                 20 
               
               
                   
                 IIIb-2 
                 25 
               
               
                   
                 Dihydrochloride 
                 10 
               
               
                   
                 salt of IIIb-3 
                   
               
               
                   
                 IIIb-8 
                 75 
               
               
                   
                 IIIb-9 
                 20 
               
               
                   
                 IIIb-10 
                 75 
               
               
                   
                 IIIb-13 
                 25 
               
               
                   
                 Dihydrochloride 
                 20 
               
               
                   
                 salt of IIIb-14 
                   
               
               
                   
                 Methylsulfonate 
                 55 
               
               
                   
                 salt of IIIb-15 
                   
               
               
                   
                 IIIb-16 
                 &gt;100 
               
               
                   
                 IIIb-17 
                 100 
               
               
                   
                 IIIb-18 
                 75 
               
               
                   
                 IIIb-19 
                 30 
               
               
                   
                 Dihydrochloride 
                 100 
               
               
                   
                 salt of IIIb-20 
                   
               
               
                   
                 IIIb-21 
                 100 
               
               
                   
                 IIIb-22 
                 &gt;100 
               
               
                   
                 IIIb-24 
                 &gt;60 
               
               
                   
                 IIIa-1 
                 45 
               
               
                   
                 IIb-23 
                 80 
               
               
                   
                 Va-1 
                 &gt;100 
               
               
                   
                 Va-3 
                 9 
               
               
                   
                 Va-4 
                 4 
               
               
                   
                 Va-5 
                 5 
               
               
                   
                 Va-7 
                 5 
               
               
                   
                 Va-9 
                 3 
               
               
                   
                 Va-10 
                 3 
               
               
                   
               
            
           
         
       
     
     The present invention is not to be limited in scope by the specific embodiments disclosed in the examples, which are intended as illustrations of a few aspects of the invention and any embodiments that are functionally equivalent are within the scope of this invention. Indeed, various modifications of the invention in addition to those shown and described herein will become apparent to those skilled in the art and are intended to fall within the scope of the appended claims. 
     A number of references have been cited, the entire disclosures of which have been incorporated herein in their entirety.